LOCUS AL123456 4411532 bp DNA linear BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv complete genome.
ACCESSION AL123456 BX842572-BX842584
VERSION AL123456.3
DBLINK BioProject:PRJNA224
BioSample:SAMEA3138326
KEYWORDS complete genome.
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Location/Qualifiers
source 1..4411532
/organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
gene 1..1524
/gene="dnaA"
/locus_tag="Rv0001"
CDS 1..1524
/codon_start=1
/transl_table=11
/gene="dnaA"
/locus_tag="Rv0001"
/product="Chromosomal replication initiator protein DnaA"
/note="Rv0001, (MT0001, MTV029.01, P49993), len: 507 aa.
dnaA, chromosomal replication initiator protein (see
citations below), equivalent to other Mycobacterial
chromosomal replication initiator proteins. Also highly
similar to others except in N-terminus e.g.
Q9ZH75|DNAA_STRCH chromosomal replication initiator
protein from Streptomyces chrysomallus (624 aa). Contains
PS00017 ATP/GTP-binding site motif A (P-loop) and PS01008
DnaA protein signature. Belongs to the DnaA family. Note
that the first base of this gene has been taken as base 1
of the Mycobacterium tuberculosis H37Rv genomic sequence."
/db_xref="EnsemblGenomes-Gn:Rv0001"
/db_xref="EnsemblGenomes-Tr:CCP42723"
/db_xref="GOA:P9WNW3"
/db_xref="InterPro:IPR001957"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR010921"
/db_xref="InterPro:IPR013159"
/db_xref="InterPro:IPR013317"
/db_xref="InterPro:IPR018312"
/db_xref="InterPro:IPR020591"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNW3"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS01008"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42723.1"
/translation="MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQ
RAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAP
PATDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPHNTDS
ATAGVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLL
HAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFI
EGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPE
LETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDK
ALAEIVLRDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYL
CRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR"
gene 2052..3260
/gene="dnaN"
/locus_tag="Rv0002"
CDS 2052..3260
/codon_start=1
/transl_table=11
/gene="dnaN"
/locus_tag="Rv0002"
/product="DNA polymerase III (beta chain) DnaN (DNA
nucleotidyltransferase)"
/note="Rv0002, (MTV029.02, MTCY10H4.0), len: 402 aa.
DnaN,DNA polymerase III (beta chain) (see citations
below),equivalent to other Mycobacterial DNA polymerases
III beta chain. Also highly similar to others e.g.
P27903|DP3B_STRCO DNA polymerase III beta chain from
Streptomyces coelicolor (376 aa). Overlaps and extends CDS
in neighbouring cosmid MTCY10H4.01."
/db_xref="EnsemblGenomes-Gn:Rv0002"
/db_xref="EnsemblGenomes-Tr:CCP42724"
/db_xref="GOA:P9WNU1"
/db_xref="InterPro:IPR001001"
/db_xref="InterPro:IPR022634"
/db_xref="InterPro:IPR022635"
/db_xref="InterPro:IPR022637"
/db_xref="PDB:3P16"
/db_xref="PDB:3RB9"
/db_xref="PDB:5AGU"
/db_xref="PDB:5AGV"
/db_xref="UniProtKB/Swiss-Prot:P9WNU1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42724.1"
/translation="MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSG
VLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHV
EGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDT
LPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAG
IGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMD
VAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIA
FNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYV
YLLMPVRLPG"
gene 3280..4437
/gene="recF"
/locus_tag="Rv0003"
CDS 3280..4437
/codon_start=1
/transl_table=11
/gene="recF"
/locus_tag="Rv0003"
/product="DNA replication and repair protein RecF
(single-strand DNA binding protein)"
/note="Rv0003, (MTCY10H4.01), len: 385 aa. RecF, DNA
replication and repair protein (see citations
below),equivalent to other mycobacterial DNA replication
and repair proteins. Also highly similar to many others.
Contains PS00017 ATP/GTP-binding site motif A
(P-loop),PS00617 RecF protein signature 1, and PS00618
RecF protein signature 2. Belongs to the RecF family."
/db_xref="EnsemblGenomes-Gn:Rv0003"
/db_xref="EnsemblGenomes-Tr:CCP42725"
/db_xref="GOA:P9WHI9"
/db_xref="InterPro:IPR001238"
/db_xref="InterPro:IPR003395"
/db_xref="InterPro:IPR018078"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR042174"
/db_xref="UniProtKB/Swiss-Prot:P9WHI9"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00617"
/inference="protein motif:PROSITE:PS00618"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42725.1"
/translation="MYVRHLGLRDFRSWACVDLELHPGRTVFVGPNGYGKTNLIEALW
YSTTLGSHRVSADLPLIRVGTDRAVISTIVVNDGRECAVDLEIATGRVNKARLNRSSV
RSTRDVVGVLRAVLFAPEDLGLVRGDPADRRRYLDDLAIVRRPAIAAVRAEYERVLRQ
RTALLKSVPGARYRGDRGVFDTLEVWDSRLAEHGAELVAARIDLVNQLAPEVKKAYQL
LAPESRSASIGYRASMDVTGPSEQSDIDRQLLAARLLAALAARRDAELERGVCLVGPH
RDDLILRLGDQPAKGFASHGEAWSLAVALRLAAYQLLRVDGGEPVLLLDDVFAELDVM
RRRALATAAESAEQVLVTAAVLEDIPAGWDARRVHIDVRADDTGSMSVVLP"
gene 4434..4997
/locus_tag="Rv0004"
CDS 4434..4997
/codon_start=1
/transl_table=11
/locus_tag="Rv0004"
/product="Conserved hypothetical protein"
/note="Rv0004, (MTCY10H4.02), len: 187 aa. Conserved
hypothetical protein (see Salazar et al., 1996). Belongs
to superfamily DUF721; this family contains several
actinomycete proteins of unknown function."
/db_xref="EnsemblGenomes-Gn:Rv0004"
/db_xref="EnsemblGenomes-Tr:CCP42726"
/db_xref="InterPro:IPR007922"
/db_xref="InterPro:IPR023007"
/db_xref="UniProtKB/Swiss-Prot:P9WFL1"
/protein_id="CCP42726.1"
/translation="MTGSVDRPDQNRGERSMKSPGLDLVRRTLDEARAAARARGQDAG
RGRVASVASGRVAGRRRSWSGPGPDIRDPQPLGKAARELAKKRGWSVRVAEGMVLGQW
SAVVGHQIAEHARPTALNDGVLSVIAESTAWATQLRIMQAQLLAKIAAAVGNDVVRSL
KITGPAAPSWRKGPRHIAGRGPRDTYG"
gene 5240..7267
/gene="gyrB"
/locus_tag="Rv0005"
CDS 5240..7267
/codon_start=1
/transl_table=11
/gene="gyrB"
/locus_tag="Rv0005"
/product="DNA gyrase (subunit B) GyrB (DNA topoisomerase
(ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA
topoisomerase)"
/note="Rv0005, (MTCY10H4.03), len: 675 aa. GyrB, DNA
gyrase subunit B (see citations below). Contains PS00177
DNA topoisomerase II signature. Belongs to the type II
topoisomerase family. Start changed since first submission
(-39 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0005"
/db_xref="EnsemblGenomes-Tr:CCP42727"
/db_xref="GOA:P9WG45"
/db_xref="InterPro:IPR001241"
/db_xref="InterPro:IPR002288"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR006171"
/db_xref="InterPro:IPR011557"
/db_xref="InterPro:IPR013506"
/db_xref="InterPro:IPR013759"
/db_xref="InterPro:IPR013760"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR018522"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR034160"
/db_xref="InterPro:IPR036890"
/db_xref="PDB:2ZJT"
/db_xref="PDB:3IG0"
/db_xref="PDB:3M4I"
/db_xref="PDB:3ZKB"
/db_xref="PDB:3ZKD"
/db_xref="PDB:3ZM7"
/db_xref="PDB:5BS8"
/db_xref="PDB:5BTA"
/db_xref="PDB:5BTC"
/db_xref="PDB:5BTD"
/db_xref="PDB:5BTF"
/db_xref="PDB:5BTG"
/db_xref="PDB:5BTI"
/db_xref="PDB:5BTL"
/db_xref="PDB:5BTN"
/db_xref="UniProtKB/Swiss-Prot:P9WG45"
/inference="protein motif:PROSITE:PS00177"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42727.1"
/translation="MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHH
LIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQ
LHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQ
GAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEV
VDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIV
DFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKD
RKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQL
THWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDP
RKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITA
LGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQP
PLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWET
TMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV"
gene 7302..9818
/gene="gyrA"
/locus_tag="Rv0006"
CDS 7302..9818
/codon_start=1
/transl_table=11
/gene="gyrA"
/locus_tag="Rv0006"
/product="DNA gyrase (subunit A) GyrA (DNA topoisomerase
(ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA
topoisomerase)"
/note="Rv0006, (MTCY10H4.04), len: 838 aa. GyrA, DNA
gyrase subunit A (see citations below). Contains PS00018
EF-hand calcium-binding domain."
/db_xref="EnsemblGenomes-Gn:Rv0006"
/db_xref="EnsemblGenomes-Tr:CCP42728"
/db_xref="GOA:P9WG47"
/db_xref="InterPro:IPR002205"
/db_xref="InterPro:IPR005743"
/db_xref="InterPro:IPR006691"
/db_xref="InterPro:IPR013757"
/db_xref="InterPro:IPR013758"
/db_xref="InterPro:IPR013760"
/db_xref="InterPro:IPR035516"
/db_xref="PDB:3IFZ"
/db_xref="PDB:3ILW"
/db_xref="PDB:3UC1"
/db_xref="PDB:4G3N"
/db_xref="PDB:5BS8"
/db_xref="PDB:5BTA"
/db_xref="PDB:5BTC"
/db_xref="PDB:5BTD"
/db_xref="PDB:5BTF"
/db_xref="PDB:5BTG"
/db_xref="PDB:5BTI"
/db_xref="PDB:5BTL"
/db_xref="PDB:5BTN"
/db_xref="PDB:6GAU"
/db_xref="PDB:6GAV"
/db_xref="UniProtKB/Swiss-Prot:P9WG47"
/inference="protein motif:PROSITE:PS00018"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42728.1"
/translation="MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEV
RDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQP
WSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRV
QEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAA
VMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPY
QVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKH
TQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILR
GLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQR
IIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDE
DLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDL
ILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLV
LATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIR
FSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEY
PVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQT
KGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN"
gene 9914..10828
/locus_tag="Rv0007"
CDS 9914..10828
/codon_start=1
/transl_table=11
/locus_tag="Rv0007"
/product="Possible conserved membrane protein"
/note="Rv0007, (MTCY10H4.05), len: 304 aa. Possible
conserved membrane protein. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0007"
/db_xref="EnsemblGenomes-Tr:CCP42729"
/db_xref="GOA:P9WMA7"
/db_xref="InterPro:IPR021949"
/db_xref="UniProtKB/Swiss-Prot:P9WMA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42729.1"
/translation="MTAPNEPGALSKGDGPNADGLVDRGGAHRAATGPGRIPDAGDPP
PWQRAATRQSQAGHRQPPPVSHPEGRPTNPPAAADARLNRFISGASAPVTGPAAAVRT
PQPDPDASLGCGDGSPAEAYASELPDLSGPTPRAPQRNPAPARPAEGGAGSRGDSAAG
SSGGRSITAESRDARVQLSARRSRGPVRASMQIRRIDPWSTLKVSLLLSVALFFVWMI
TVAFLYLVLGGMGVWAKLNSNVGDLLNNASGSSAELVSSGTIFGGAFLIGLVNIVLMT
ALATIGAFVYNLITDLIGGIEVTLADRD"
gene 10887..10960
/gene="ileT"
tRNA 10887..10960
/gene="ileT"
/product="tRNA-Ile"
/anticodon=(pos:10921..10923,aa:Ile,seq:gat)
/note="codon recognized: AUC; ileT, tRNA-Ile, anticodon
gat, length = 74"
gene 11112..11184
/gene="alaT"
tRNA 11112..11184
/gene="alaT"
/product="tRNA-Ala"
/anticodon=(pos:11145..11147,aa:Ala,seq:tgc)
/note="codon recognized: GCA; alaT, tRNA-Ala, anticodon
tgc, length = 73"
gene complement(11874..12311)
/locus_tag="Rv0008c"
CDS complement(11874..12311)
/codon_start=1
/transl_table=11
/locus_tag="Rv0008c"
/product="Possible membrane protein"
/note="Rv0008c, (MTCY10H4.07c), len: 145 aa. Possible
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv0008c"
/db_xref="EnsemblGenomes-Tr:CCP42730"
/db_xref="GOA:P9WJF3"
/db_xref="InterPro:IPR024245"
/db_xref="UniProtKB/Swiss-Prot:P9WJF3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42730.1"
/translation="MSEQVETRLTPRERLTRGLAYSAVGPVDVTRGLLELGVGLGLQS
ARSTAAGLRRRYREGRLAREVAAAQETLAQELTAAQDVVANLPQALQDARTQRRSKHH
LWIFAGIAAAILAGGAVAFSIVRRSSRPEPSPRPPSVEVQPRS"
gene 12468..13016
/gene="ppiA"
/gene_synonym="cfp22"
/locus_tag="Rv0009"
CDS 12468..13016
/codon_start=1
/transl_table=11
/gene="ppiA"
/gene_synonym="cfp22"
/locus_tag="Rv0009"
/product="Probable iron-regulated peptidyl-prolyl
cis-trans isomerase A PpiA (PPIase A) (rotamase A)"
/note="Rv0009, (MTCY10H4.08), len: 182 aa. Probable ppiA
(alternate gene name: cfp22), iron-regulated
peptidyl-prolyl cis-trans isomerase A. Belongs to the
cyclophilin-type PPIase family. Alternative start codon
has been suggested."
/db_xref="EnsemblGenomes-Gn:Rv0009"
/db_xref="EnsemblGenomes-Tr:CCP42731"
/db_xref="GOA:P9WHW3"
/db_xref="InterPro:IPR002130"
/db_xref="InterPro:IPR020892"
/db_xref="InterPro:IPR024936"
/db_xref="InterPro:IPR029000"
/db_xref="PDB:1W74"
/db_xref="UniProtKB/Swiss-Prot:P9WHW3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42731.1"
/translation="MADCDSVTNSPLATATATLHTNRGDIKIALFGNHAPKTVANFVG
LAQGTKDYSTQNASGGPSGPFYDGAVFHRVIQGFMIQGGDPTGTGRGGPGYKFADEFH
PELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVIDAESQRVVEAIS
KTATDGNDRPTDPVVIESITIS"
gene complement(13133..13558)
/locus_tag="Rv0010c"
CDS complement(13133..13558)
/codon_start=1
/transl_table=11
/locus_tag="Rv0010c"
/product="Probable conserved membrane protein"
/note="Rv0010c, (MTCY10H4.10c), len: 141 aa. Probable
conserved membrane protein. Belongs to superfamily
DUF2581,conserved in the Actinomycetales. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0010c"
/db_xref="EnsemblGenomes-Tr:CCP42732"
/db_xref="GOA:P9WMA3"
/db_xref="InterPro:IPR019692"
/db_xref="UniProtKB/Swiss-Prot:P9WMA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42732.1"
/translation="MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAA
LGLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLL
EIETVSGGLLILSRWDLGTDPVEVLDALTAAGYAGRGQR"
gene complement(13714..13995)
/locus_tag="Rv0011c"
CDS complement(13714..13995)
/codon_start=1
/transl_table=11
/locus_tag="Rv0011c"
/product="Probable conserved transmembrane protein"
/note="Rv0011c, (MTCY10H4.11c), len: 93 aa. Probable
conserved transmembrane protein. Belongs to
uncharacterized protein family UPF0233. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0011c"
/db_xref="EnsemblGenomes-Tr:CCP42733"
/db_xref="GOA:P9WP57"
/db_xref="InterPro:IPR009619"
/db_xref="PDB:2MMU"
/db_xref="UniProtKB/Swiss-Prot:P9WP57"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42733.1"
/translation="MPKSKVRKKNDFTVSAVSRTPMKVKVGPSSVWFVSLFIGLMLIG
LIWLMVFQLAAIGSQAPTALNWMAQLGPWNYAIAFAFMITGLLLTMRWH"
gene 14089..14877
/locus_tag="Rv0012"
CDS 14089..14877
/codon_start=1
/transl_table=11
/locus_tag="Rv0012"
/product="Probable conserved membrane protein"
/note="Rv0012, (MTCY10H4.12), len: 262 aa. Probable
conserved membrane protein. Belongs to superfamily DUF881.
Contains probable N-terminal signal sequence."
/db_xref="EnsemblGenomes-Gn:Rv0012"
/db_xref="EnsemblGenomes-Tr:CCP42734"
/db_xref="InterPro:IPR010273"
/db_xref="UniProtKB/TrEMBL:L0T243"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42734.1"
/translation="MRLTHPTPCPENGETMIDRRRSAWRFSVPLVCLLAGLLLAATHG
VSGGTEIRRSDAPRLVDLVRRAQASVNRLATEREALTTRIDSVHGRSVDTALAAMQRR
SAKLAGVAAMNPVHGPGLVVTLQDAQRDANGRFPRDASPDDLVVHQQDIEAVLNALWN
AGAEAIQMQDQRIIAMSIARCVGNTLLLNGRTYSPPYTIAAIGDAAAMQAALAAAPLV
TLYKQYVVRFGLGYCEEVHPDLQIVGYADPVRMHFAQPAGPLDY"
gene 14914..15612
/gene="trpG"
/gene_synonym="pabA"
/locus_tag="Rv0013"
CDS 14914..15612
/codon_start=1
/transl_table=11
/gene="trpG"
/gene_synonym="pabA"
/locus_tag="Rv0013"
/product="Possible anthranilate synthase component II TrpG
(glutamine amidotransferase)"
/note="Rv0013, (MTCY10H4.13), len: 232 aa. Possible
trpG,anthranilate synthase component II (glutamine
amidotransferase). Contains PS00606 Beta-ketoacyl
synthases active site; and PS00442 Glutamine
amidotransferases class-I active site. Similarity to other
type-1 glutamine amidotransferase domains. Note that
previously known as pabA."
/db_xref="EnsemblGenomes-Gn:Rv0013"
/db_xref="EnsemblGenomes-Tr:CCP42735"
/db_xref="GOA:P9WN35"
/db_xref="InterPro:IPR006221"
/db_xref="InterPro:IPR017926"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:P9WN35"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00442"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42735.1"
/translation="MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVA
GQFDGVLLSPGPGTPERAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATVDRAPE
LLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQ
HTGLPIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLENEVLTAISPHFPT
STASAGEATGRTSA"
gene complement(15590..17470)
/gene="pknB"
/locus_tag="Rv0014c"
CDS complement(15590..17470)
/codon_start=1
/transl_table=11
/gene="pknB"
/locus_tag="Rv0014c"
/product="Transmembrane serine/threonine-protein kinase B
PknB (protein kinase B) (STPK B)"
/note="Rv0014c, (MTCY10H4.14c), len: 626 aa.
PknB,transmembrane serine/threonine-protein kinase (see
citations below). Contains PS00107 Protein kinases
ATP-binding region signature, and PS00108 Serine/Threonine
protein kinases active-site signature. Contains Hank's
kinase subdomain. Belongs to the Ser/Thr family of protein
kinases. Experimental studies show evidence of
auto-phosphorylation on serine/threonine residues. PknB
has been shown to be a substrate for PstP and its kinase
activity is affected by PstP-mediated dephosphorylation.
PknB and PstP (Rv0018c) may act as a functional pair in
vivo to control mycobacterial cell growth."
/db_xref="EnsemblGenomes-Gn:Rv0014c"
/db_xref="EnsemblGenomes-Tr:CCP42736"
/db_xref="GOA:P9WI81"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR005543"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR017441"
/db_xref="PDB:1MRU"
/db_xref="PDB:1O6Y"
/db_xref="PDB:2FUM"
/db_xref="PDB:2KUD"
/db_xref="PDB:2KUE"
/db_xref="PDB:2KUF"
/db_xref="PDB:2KUI"
/db_xref="PDB:3F61"
/db_xref="PDB:3F69"
/db_xref="PDB:3ORI"
/db_xref="PDB:3ORO"
/db_xref="PDB:5E0Y"
/db_xref="PDB:5E0Z"
/db_xref="PDB:5E10"
/db_xref="PDB:5E12"
/db_xref="PDB:5U94"
/db_xref="PDB:6B2P"
/db_xref="PDB:6I2P"
/db_xref="UniProtKB/Swiss-Prot:P9WI81"
/inference="protein motif:PROSITE:PS00108"
/inference="protein motif:PROSITE:PS00107"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42736.1"
/translation="MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRA
DLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD
IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIA
RAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG
DSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRV
HNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVA
VVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDS
TIPPDHVIGTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFG
RFKQANSPSTPELVGKVIGTNPPANQTSAITNVVIIIVGSGPATKDIPDVAGQTVDVA
QKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQFVMPDL
SGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRF
GQ"
gene complement(17467..18762)
/gene="pknA"
/locus_tag="Rv0015c"
CDS complement(17467..18762)
/codon_start=1
/transl_table=11
/gene="pknA"
/locus_tag="Rv0015c"
/product="Transmembrane serine/threonine-protein kinase A
PknA (protein kinase A) (STPK A)"
/note="Rv0015c, (MTCY10H4.15c), len: 431 aa.
PknA,transmembrane serine/threonine-protein
kinase,magnesium/manganese dependent (see citations
below). Contains PS00108 Serine/Threonine protein kinases
active-site signature. Contains Hank's kinase subdomain.
Belongs to the Ser/Thr family of protein kinases. It has
been shown that sodium orthovanadate inhibits the activity
of the enzyme in vitro."
/db_xref="EnsemblGenomes-Gn:Rv0015c"
/db_xref="EnsemblGenomes-Tr:CCP42737"
/db_xref="GOA:P9WI83"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="PDB:4OW8"
/db_xref="PDB:4X3F"
/db_xref="PDB:6B2Q"
/db_xref="UniProtKB/Swiss-Prot:P9WI83"
/inference="protein motif:PROSITE:PS00108"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42737.1"
/translation="MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVL
KSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEP
LNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDF
GIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFA
GDGALTVAMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAVAAVRA
GRRPPRPSQTPPPGRAAPAAIPSGTTARVAANSAGRTAASRRSRPATGGHRPPRRTFS
SGQRALLWAAGVLGALAIIIAVLLVIKAPGDNSPQQAPTPTVTTTGNPPASNTGGTDA
SPRLNWTERGETRHSGLQSWVVPPTPHSRASLARYEIAQ"
gene complement(18759..20234)
/gene="pbpA"
/locus_tag="Rv0016c"
CDS complement(18759..20234)
/codon_start=1
/transl_table=11
/gene="pbpA"
/locus_tag="Rv0016c"
/product="Probable penicillin-binding protein PbpA"
/note="Rv0016c, (MTCY10H4.16c), len: 491 aa. Probable
pbpA,penicillin-binding protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv0016c"
/db_xref="EnsemblGenomes-Tr:CCP42738"
/db_xref="GOA:P9WKD1"
/db_xref="InterPro:IPR001460"
/db_xref="InterPro:IPR012338"
/db_xref="PDB:3LO7"
/db_xref="PDB:3UN7"
/db_xref="PDB:3UPN"
/db_xref="PDB:3UPO"
/db_xref="PDB:3UPP"
/db_xref="UniProtKB/Swiss-Prot:P9WKD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42738.1"
/translation="MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVL
LDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALER
AEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKG
AVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETY
PPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLRE
AFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGM
TSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVS
PQVAAKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQ
APKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQGEP"
gene complement(20231..21640)
/gene="rodA"
/gene_synonym="ftsW"
/locus_tag="Rv0017c"
CDS complement(20231..21640)
/codon_start=1
/transl_table=11
/gene="rodA"
/gene_synonym="ftsW"
/locus_tag="Rv0017c"
/product="Probable cell division protein RodA"
/note="Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA
(alternate gene name: ftsW), cell division
protein,integral membrane protein. Belongs to the
FTSW/RODA/SPOVE family."
/db_xref="EnsemblGenomes-Gn:Rv0017c"
/db_xref="EnsemblGenomes-Tr:CCP42739"
/db_xref="GOA:P9WN99"
/db_xref="InterPro:IPR001182"
/db_xref="InterPro:IPR018365"
/db_xref="UniProtKB/Swiss-Prot:P9WN99"
/protein_id="CCP42739.1"
/translation="MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQ
DQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLV
DNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPA
LLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGM
TLPRPRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTL
FAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQP
DTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLS
STLAIQLFIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRT
RPRNKSPITAAGTEVIERV"
gene complement(21637..23181)
/gene="pstP"
/locus_tag="Rv0018c"
CDS complement(21637..23181)
/codon_start=1
/transl_table=11
/gene="pstP"
/locus_tag="Rv0018c"
/product="Phosphoserine/threonine phosphatase PstP"
/note="Rv0018c, (MTCY10H4.18c), len: 514 aa.
PstP,phosphoserine/threonine phosphatase. Experimental
studies have shown that PstP specifically dephosporylates
model phospho-Ser/Thr substrates and it is likely that
PknB (Rv0014c) and PstP may act as a functional pair in
vivo to control mycobacterial cell growth (See Boitel et
al.,2003)."
/db_xref="EnsemblGenomes-Gn:Rv0018c"
/db_xref="EnsemblGenomes-Tr:CCP42740"
/db_xref="GOA:P9WHW5"
/db_xref="InterPro:IPR001932"
/db_xref="InterPro:IPR015655"
/db_xref="InterPro:IPR036457"
/db_xref="PDB:1TXO"
/db_xref="PDB:2CM1"
/db_xref="UniProtKB/Swiss-Prot:P9WHW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42740.1"
/translation="MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHA
AGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLT
AILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRS
LIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRL
IELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQ
RKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAG
SVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPE
RAQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVT
SSPASPSPTTSAPAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGI
DCRAAA"
repeat_region complement(23173..23273)
/note="101 bp Mycobacterial Interspersed Repetitive
Unit,Class I. See Supply et al. (1997) Molecular
Microbiology 26, 991-1003"
gene complement(23270..23737)
/gene="fhaB"
/locus_tag="Rv0019c"
CDS complement(23270..23737)
/codon_start=1
/transl_table=11
/gene="fhaB"
/locus_tag="Rv0019c"
/product="Conserved protein with FHA domain, FhaB"
/note="Rv0019c, (MTCY10H4.19c), len: 155 aa.
FhaB,conserved protein with forkhead-associated domain
(IPR000253), probably involved in signal transduction."
/db_xref="EnsemblGenomes-Gn:Rv0019c"
/db_xref="EnsemblGenomes-Tr:CCP42741"
/db_xref="GOA:P9WJB5"
/db_xref="InterPro:IPR000253"
/db_xref="InterPro:IPR008984"
/db_xref="InterPro:IPR032030"
/db_xref="UniProtKB/Swiss-Prot:P9WJB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42741.1"
/translation="MQGLVLQLTRAGFLMLLWVFIWSVLRILKTDIYAPTGAVMMRRG
LALRGTLLGARQRRHAARYLVVTEGALTGARITLSEQPVLIGRADDSTLVLTDDYAST
RHARLSMRGSEWYVEDLGSTNGTYLDRAKVTTAVRVPIGTPVRIGKTAIELRP"
gene complement(23861..25444)
/gene="fhaA"
/gene_synonym="TB39.8"
/locus_tag="Rv0020c"
CDS complement(23861..25444)
/codon_start=1
/transl_table=11
/gene="fhaA"
/gene_synonym="TB39.8"
/locus_tag="Rv0020c"
/product="Conserved protein with FHA domain, FhaA"
/note="Rv0020c, (MTCY10H4.20c), len: 527 aa. FhaA,
TB39.8,conserved protein with forkhead-associated domain
(IPR000253) at C-terminus, may be involved in signal
transduction. Alternative start codon in position 24979
has been suggested (see citation below). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0020c"
/db_xref="EnsemblGenomes-Tr:CCP42742"
/db_xref="GOA:P71590"
/db_xref="InterPro:IPR000253"
/db_xref="InterPro:IPR008984"
/db_xref="InterPro:IPR022128"
/db_xref="InterPro:IPR042287"
/db_xref="PDB:2LC0"
/db_xref="PDB:2LC1"
/db_xref="PDB:3OUN"
/db_xref="PDB:3PO8"
/db_xref="PDB:3POA"
/db_xref="UniProtKB/Swiss-Prot:P71590"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42742.1"
/translation="MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREA
ADGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGWQTYG
DVVVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNS
SYRGGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRP
RHPDQGDYPEQIGYPDQGGYPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYE
QRPPVSPGPAAGYGAPGYDQGYRQSGGYGPSPGGGQPGYGGYGEYGRGPARHEEGSYV
PSGPPGPPEQRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYTRYTESPRVPGYAPQG
GGYAEPAGRDYDYGQSGAPDYGQPAPGGYSGYGQGGYGSAGTSVTLQLDDGSGRTYQL
REGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQ
LADGDVIRLGHSEIIVRMH"
gene 25644..25726
/gene="leuT"
tRNA 25644..25726
/gene="leuT"
/product="tRNA-Leu"
/anticodon=(pos:25677..25679,aa:Leu,seq:cag)
/note="codon recognized: CUG; leuT, tRNA-Leu, anticodon
cag, length = 83"
gene complement(25913..26881)
/locus_tag="Rv0021c"
CDS complement(25913..26881)
/codon_start=1
/transl_table=11
/locus_tag="Rv0021c"
/product="Conserved hypothetical protein"
/note="Rv0021c, (MTCY10H4.21c), len: 322 aa. Conserved
hypothetical protein, similar to various proteins."
/db_xref="EnsemblGenomes-Gn:Rv0021c"
/db_xref="EnsemblGenomes-Tr:CCP42743"
/db_xref="GOA:P71591"
/db_xref="InterPro:IPR004136"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:P71591"
/protein_id="CCP42743.1"
/translation="MVLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIG
GGYGDRDWLARQFDLAAGAPVGCGFITWSLARQPQLLDLALQYEPVAVMLSFGDPAVF
ADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVD
LVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQARDPLLA
ATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAV
AARDYSIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV"
gene complement(27023..27442)
/gene="whiB5"
/gene_synonym="whmG"
/locus_tag="Rv0022c"
CDS complement(27023..27442)
/codon_start=1
/transl_table=11
/gene="whiB5"
/gene_synonym="whmG"
/locus_tag="Rv0022c"
/product="Probable transcriptional regulatory protein
WhiB-like WhiB5"
/note="Rv0022c, (MTCY10H4.22c), len: 139 aa. Probable
whiB5 (alternate gene name: whmG), WhiB-like regulatory
protein (see citations below), similar to WhiB paralogue
of Streptomyces coelicolor, wblE gene product (85 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0022c"
/db_xref="EnsemblGenomes-Tr:CCP42744"
/db_xref="GOA:P71592"
/db_xref="InterPro:IPR003482"
/db_xref="InterPro:IPR034768"
/db_xref="UniProtKB/Swiss-Prot:P71592"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42744.1"
/translation="MAHPCATDPELWFGYPDDDGSDGAAKARAYERSATQARIQCLRR
CPLLQQRRCAQHAVEHRVEYGVWAGIKLPGGQYRKREQLAAAHDVLRRIAGGEINSRQ
LPDNAALLARNEGLEVTPVPGVVVHLPIAQVGPQPAA"
gene 27595..28365
/locus_tag="Rv0023"
CDS 27595..28365
/codon_start=1
/transl_table=11
/locus_tag="Rv0023"
/product="Possible transcriptional regulatory protein"
/note="Rv0023, (MTCY10H4.23), len: 256 aa. Possible
transcriptional regulator. Contains probable helix-turn
helix motif from aa 19 to 40 (Score 1615, +4.69 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0023"
/db_xref="EnsemblGenomes-Tr:CCP42745"
/db_xref="GOA:P9WMI3"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010982"
/db_xref="UniProtKB/Swiss-Prot:P9WMI3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42745.1"
/translation="MSRESAGAAIRALRESRDWSLADLAAATGVSTMGLSYLERGARK
PHKSTVQKVENGLGLPPGTYSRLLVAADPDAELARLIAAQPSNPTAVRRAGAVVVDRH
SDTDVLEGYAEAQLDAIKSVIDRLPATTSNEYETYILSVIAQCVKAEMLAASSWRVAV
NAGADSTGRLMEHLRALEATRGALLERMPTSLSARFDRACAQSSLPEAVVAALIGVGA
DEMWDIRNRGVIPAGALPRVRAFVDAIEASHDADEGQQ"
gene 28362..29207
/locus_tag="Rv0024"
CDS 28362..29207
/codon_start=1
/transl_table=11
/locus_tag="Rv0024"
/product="Putative secreted protein P60-related protein"
/note="Rv0024, (MTCY10H4.24), len: 281 aa. Putative
secreted protein, p60 homologue, similar to many. Similar
to Mycobacterium tuberculosis proteins Rv1477,
Rv1478,Rv1566c, Rv2190c. Could belong to the E. coli NLPC
/ listeria P60 family."
/db_xref="EnsemblGenomes-Gn:Rv0024"
/db_xref="EnsemblGenomes-Tr:CCP42746"
/db_xref="GOA:P71594"
/db_xref="InterPro:IPR000064"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/TrEMBL:P71594"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42746.1"
/translation="MNYSEVELLSRAHQLFAGDSRRPGLDAGTTPYGDLLSRAADLNV
GAGQRRYQLAVDHSRAALLSAARTDAAAGAVITGAQRDRAWARRSTGTVLDEARSDTT
VTAVMPIAQREAIRRRVARLRAQRAHVLTARRRARRHLAALRALRYRVAHGPGVALAK
LRLPSPSGRAGIAVHAALSRLGRPYVWGATGPNQFDCSGLVQWAYAQAGVHLDRTTYQ
QINEGIPVPRSQVRPGDLVFPHPGHVQLAIGNNLVVEAPHAGASVRVSSLGNNVQIRR
PLSGR"
gene 29245..29607
/locus_tag="Rv0025"
CDS 29245..29607
/codon_start=1
/transl_table=11
/locus_tag="Rv0025"
/product="Conserved hypothetical protein"
/note="Rv0025, (MTCY10H4.25), len: 120 aa. Conserved
hypothetical protein, showing some similarity to other
proteins from Mycobacterium tuberculosis e.g. Rv0739 (268
aa), FASTA score: (37.6% identity in 101 aa overlap), and
Rv0026 FASTA score: (35.4% identity in 113 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv0025"
/db_xref="EnsemblGenomes-Tr:CCP42747"
/db_xref="InterPro:IPR019710"
/db_xref="UniProtKB/Swiss-Prot:P9WMA1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42747.1"
/translation="MSEQAGSSVAVIQERQALLARQHDAVAEADRELADVLASAHAAM
RESVRRLDAIAAELDRAVPDQDQLAVDTPMGAREFQTFLVAKQREIVAVVAAAHELDR
AKSAVLKRLRAQYTEPAR"
gene 29722..31068
/locus_tag="Rv0026"
CDS 29722..31068
/codon_start=1
/transl_table=11
/locus_tag="Rv0026"
/product="Conserved hypothetical protein"
/note="Rv0026, (MTCY10H4.26), len: 448 aa. Conserved
hypothetical protein, showing some similarity to other
proteins from Mycobacterium tuberculosis: Rv0025 FASTA
score: (35.4% identity in 113 aa overlap) and Rv0739 (268
aa), FASTA score: (32.4% identity in 142 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0026"
/db_xref="EnsemblGenomes-Tr:CCP42748"
/db_xref="InterPro:IPR019710"
/db_xref="UniProtKB/Swiss-Prot:P9WMB1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42748.1"
/translation="MAFDAAMSTHEDLLATIRYVRDRTGDPNAWQTGLTPTEVTAVVT
STTRSEQLDAILRKIRQRHSNLYYPAPPDREQGDAARAIADAEAALAHQNSATAQLDL
QVVSAILNAHLKTVEGGESLHELQQEIEAAVRIRSDLDTPAGARDFQRFLIGKLKDIR
EVVATASLDAASKSALMAAWTSLYDASKGDRGDADDRGPASVGSGGAPARGAGQQPEL
PTRAEPDCLLDSLLLEDPGLLADDLQVPGGTSAAIPSASSTPSLPNLGGATMPGGGAT
PALVPGVSAPGGLPLSGLLRGVGDEPELTDFDERGQEVRDPADYEHSNEPDERRADDR
EGADEDAGLGKSESPPQAPTTVTLPNGETVTAASPQLAAAIKAAASGTPIADAFQQQG
IAIPLPGTAVANPVDPARISAGDVGVFTATPLPLALAKLFWTARFNTSQPCEGQTF"
gene 31189..31506
/locus_tag="Rv0027"
CDS 31189..31506
/codon_start=1
/transl_table=11
/locus_tag="Rv0027"
/product="Conserved hypothetical protein"
/note="Rv0027, (MTCY10H4.27), len: 105 aa. Conserved
hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0027"
/db_xref="EnsemblGenomes-Tr:CCP42749"
/db_xref="GOA:P9WM99"
/db_xref="InterPro:IPR022536"
/db_xref="UniProtKB/Swiss-Prot:P9WM99"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42749.1"
/translation="MTDRIHVQPAHLRQAAAHHQQTADYLRTVPSSHDAIRESLDSLG
PIFSELRDTGRELLELRKQCYQQQADNHADIAQNLRTSAAMWEQHERAASRSLGNIID
GSR"
gene 31514..31819
/locus_tag="Rv0028"
CDS 31514..31819
/codon_start=1
/transl_table=11
/locus_tag="Rv0028"
/product="Conserved hypothetical protein"
/note="Rv0028, (MTCY10H4.28), len: 101 aa. Conserved
hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0028"
/db_xref="EnsemblGenomes-Tr:CCP42750"
/db_xref="InterPro:IPR024426"
/db_xref="UniProtKB/Swiss-Prot:P9WM97"
/protein_id="CCP42750.1"
/translation="MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETL
AEAILLTADVSCLKALLEVRNEIVAAGHTPSAQVPTTDDLNVAIEKLLAHQLRRRNR"
gene 32057..33154
/locus_tag="Rv0029"
CDS 32057..33154
/codon_start=1
/transl_table=11
/locus_tag="Rv0029"
/product="Conserved hypothetical protein"
/note="Rv0029, (MTCY10H4.29), len: 365 aa. Conserved
hypothetical protein, showing some similarity to other
proteins from Mycobacterium tuberculosis e.g. C-terminal
region of Rv2082; Rv3899c."
/db_xref="EnsemblGenomes-Gn:Rv0029"
/db_xref="EnsemblGenomes-Tr:CCP42751"
/db_xref="GOA:P71599"
/db_xref="InterPro:IPR040604"
/db_xref="InterPro:IPR040833"
/db_xref="UniProtKB/TrEMBL:P71599"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42751.1"
/translation="MAIFGRWSARQRLRRATRESLTIPTFSSSLDCTTRVIGGLWPAE
LSSNTAETATLAEHLKADLHRIVGSANDELMVIWRAGMADSTRRAEEDRVIDRARASA
MRRVESAMRELRQITGRVPVEIPRMRGAGGSDLDTTRLMPAVTVVQPADQACTDWPVA
AAEDDEARLQRLLAFVARQEPRLNWAVGVHADGTTVLVTDVAHGWIPPGIALPEGVRL
LAPARRAGRAPELVGITTCCKTYTPGDSLRRAVDSTAPTSSVQPRALPAIAGLSVELG
IATQRHDGLPKIVHAMATAAGNGAAAEEVDLLRVHVDTALHHVLAQYPRVDPALLLNC
MLLAATERSVTGDPIAANYHFAWFRELDSRR"
gene 33224..33553
/locus_tag="Rv0030"
CDS 33224..33553
/codon_start=1
/transl_table=11
/locus_tag="Rv0030"
/product="Conserved hypothetical protein"
/note="Rv0030, (MTCY10H4.30), len: 109 aa. Conserved
hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0030"
/db_xref="EnsemblGenomes-Tr:CCP42752"
/db_xref="InterPro:IPR024296"
/db_xref="UniProtKB/Swiss-Prot:P9WM95"
/protein_id="CCP42752.1"
/translation="MVSGSDSRSEPSQLSDRDLVESVLRDLSEAADKWEALVTQAETV
TYSVDLGDVRAVANSDGRLLELTLHPGVMTGYAHGELADRVNLAITALRDEVEAENRA
RYGGRLQ"
gene 33582..33794
/locus_tag="Rv0031"
CDS 33582..33794
/codon_start=1
/transl_table=11
/locus_tag="Rv0031"
/product="Possible remnant of a transposase"
/note="Rv0031, (MTCY10H4.31), len: 70 aa. Possible remnant
of a transposase, showing partial similarity to
mycobacterial transposases in a short overlap, e.g.
Rv2791c|MTV002_57 (459 aa), FASTA score: (72.2% identity
in 36 aa overlap); Rv2885c, Rv2978c, Rv3827c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0031"
/db_xref="EnsemblGenomes-Tr:CCP42753"
/db_xref="UniProtKB/TrEMBL:P71601"
/protein_id="CCP42753.1"
/translation="MLARHFGAGRKAHSRAVATLKADIQAWHPAGIQTPKPRCESDVF
ARIGHTSHPSTRKSRVGPGASEAPLA"
gene 34295..36610
/gene="bioF2"
/locus_tag="Rv0032"
CDS 34295..36610
/codon_start=1
/transl_table=11
/gene="bioF2"
/locus_tag="Rv0032"
/product="Possible 8-amino-7-oxononanoate synthase BioF2
(AONS) (8-amino-7-ketopelargonate synthase)
(7-keto-8-amino-pelargonic acid synthetase) (7-KAP
synthetase) (L-alanine--pimelyl CoA ligase)"
/note="Rv0032, (MTCY10H4.32), len: 771 aa. Probable
bioF2,8-amino-7-oxononanoate synthase, with its C-terminal
similar to others. Contains PS00599 Aminotransferases
class-II pyridoxal-phosphate attachment site. Belongs to
class-II of pyridoxal-phosphate-dependent
aminotransferases."
/db_xref="EnsemblGenomes-Gn:Rv0032"
/db_xref="EnsemblGenomes-Tr:CCP42754"
/db_xref="GOA:P9WQ85"
/db_xref="InterPro:IPR001917"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR016181"
/db_xref="InterPro:IPR038740"
/db_xref="UniProtKB/Swiss-Prot:P9WQ85"
/inference="protein motif:PROSITE:PS00599"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42754.1"
/translation="MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSV
CFDLATTDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVLPV
LAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRVDTTISWSSVE
EALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKTEAKDYQRE
DLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYR
KANLYRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHT
ATLARMMMHNIQRPTLPDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKL
GGVYGFYPRFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESGDMIIQDAL
NHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGTVADLAT
IAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFI
AGDRPVVDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATG
LARQGYQAEYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTS
YLADHRQSDLDRALHVFAGLAEDLTPQGAAL"
gene 36607..36870
/gene="acpA"
/gene_synonym="acpP"
/locus_tag="Rv0033"
CDS 36607..36870
/codon_start=1
/transl_table=11
/gene="acpA"
/gene_synonym="acpP"
/locus_tag="Rv0033"
/product="Probable acyl carrier protein AcpA (ACP)"
/note="Rv0033, (MTCY10H4.33), len: 87 aa. Probable acpA
(alternate gene name: acpP), acyl carrier protein, similar
to others. Also similar to proteins of Mycobacterium
tuberculosis Rv1344 and Rv2244 (31.5% identity in 73 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0033"
/db_xref="EnsemblGenomes-Tr:CCP42755"
/db_xref="GOA:I6WX95"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/TrEMBL:I6WX95"
/protein_id="CCP42755.1"
/translation="MKEAINATIQRILRTDRGITANQVLVDDLGFDSLKLFQLITELE
DEFDIAISFRDAQNIKTVGDVYTSVAVWFPETAKPAPLGKGTA"
gene 36867..37262
/locus_tag="Rv0034"
CDS 36867..37262
/codon_start=1
/transl_table=11
/locus_tag="Rv0034"
/product="Conserved hypothetical protein"
/note="Rv0034, (MTCY10H4.34), len: 131 aa. Conserved
hypothetical protein, showing weak similarity to
AE001980|AE001980_7 hypothetical protein from Deinococcus
radiodurans (120 aa), FASTA scores: opt: 141, E():
0.0028,(29.3% identity in 123 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0034"
/db_xref="EnsemblGenomes-Tr:CCP42756"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/Swiss-Prot:P9WM93"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42756.1"
/translation="MTDDADLDLVRRTFAAFARGDLAELTQCFAPDVEQFVPGKHALA
GVFRGVDNVVACLGDTAAAADGTMTVTLEDVLSNTDGQVIAVYRLRASRAGKVLDQRE
AILVTVAGGRITRLSEFYADPAATESFWA"
gene 37259..38947
/gene="fadD34"
/locus_tag="Rv0035"
CDS 37259..38947
/codon_start=1
/transl_table=11
/gene="fadD34"
/locus_tag="Rv0035"
/product="Probable fatty-acid-CoA ligase FadD34
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0035, (MTCY10H4.35), len: 562 aa. Probable
fadD34,fatty-acid-CoA synthetase, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv0035"
/db_xref="EnsemblGenomes-Tr:CCP42757"
/db_xref="GOA:L7N699"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:L7N699"
/protein_id="CCP42757.1"
/translation="MTAALLSPAIAWQQISACTDRTLTITCEDSEVISYQDLIARAAA
CIPPLRRLDLKRGEPVLITAHTNLEFLSCFLGLMLHGAVPVPIPPREALKTTERFMTR
LGPLLRHHRVLICTPAEHDEIRAAASTDCQISRFTALAEAGDEQFGRATAQQLADTAT
ADWPLCTLDDDAYVQYTSGSTAAPRGVVITYRNLLSNMRAMAVGSQFQHGDVMGSWLP
LHHDMGLVGSLFAALFNSVSAVFTTPHRFLYDPLGFLRLLTSSGATHTFMPNFALEWL
INAYHRRGADIEGIDLHKMRRLIIASEPVHAEGMRRFAATFAGVGLAPTALGSGYGLA
EATVAVSMSAPNTGFRTETHAAAEVVTGGRVLPGYEVRIDAAPGARAGTIKLRGDSVA
AKAYVGGKKLDALDEEGFCDTHDLGFLVDDEIVILGRQDEVFIVHGENRFPYDIEFII
RGESEQHRTKVACFGVNERVVVVLESPLDSIIDKAEADRLRCQVVAATGLQLDELITV
RRGAIPTTTSGKLKRRAVAQAYRDGTLPRLATHAWTADPDSAPKTTRSSLEGAH"
gene complement(39056..39829)
/locus_tag="Rv0036c"
CDS complement(39056..39829)
/codon_start=1
/transl_table=11
/locus_tag="Rv0036c"
/product="Conserved protein"
/note="Rv0036c, (MTCY10H4.36c), len: 257 aa. Conserved
protein, highly similar to CAB95889.1|AL359988 conserved
hypothetical protein from Streptomyces (276 aa). Also some
similarity to Rv3099c|MTCY164_10 (283 aa), FASTA scores:
E(): 3.3e-05, (25.9% identity in 205 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0036c"
/db_xref="EnsemblGenomes-Tr:CCP42758"
/db_xref="GOA:P9WM91"
/db_xref="InterPro:IPR013917"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR017518"
/db_xref="InterPro:IPR024344"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/Swiss-Prot:P9WM91"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42758.1"
/translation="MADPGPFVADLRAESDDLDALVAHLPADRWADPTPAPGWTIAHQ
IGHLLWTDRVALTAVTDEAGFAELMTAAAANPAGFVDDAATELAAVSPAELLTDWRVT
RGRLHEELLAVPDGRKLAWFGPPMSAASMATARLMETWAHGLDVADALGVIRPATQRL
RSIAHLGVRTRDYAFIVNNLTPPAEPFLVELRGPSGDTWSWGPSDAAQRVTGSAEDFC
FLVTQRRALSTLDVNAVGEDAQRWLTIAQAFAGPPGRGR"
gene complement(39877..41202)
/locus_tag="Rv0037c"
CDS complement(39877..41202)
/codon_start=1
/transl_table=11
/locus_tag="Rv0037c"
/product="Probable conserved integral membrane protein"
/note="Rv0037c, (MTCY10H4.37c), len: 441 aa. Probable
conserved integral membrane protein, member of major
facilitator superfamily (MFS) possibly involved in
transport of macrolide."
/db_xref="EnsemblGenomes-Gn:Rv0037c"
/db_xref="EnsemblGenomes-Tr:CCP42759"
/db_xref="GOA:P9WJY1"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJY1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42759.1"
/translation="MPRVEVGLVIHSRMHARAPVDVWRSVRSLPDFWRLLQVRVASQF
GDGLFQAGLAGALLFNPDRAADPMAIAGAFAVLFLPYSLLGPFAGALMDRWDRRWVLV
GANTGRLALIAGVGTILAVGAGDVPLLVGALVANGLARFVASGLSAALPHVVPREQVV
TMNSVAIASGAVSAFLGANFMLLPRWLLGSGDEGASAIVFLVAIPVSIALLWSLRFGP
RVLGPDDTERAIHGSAVYAVVTGWLHGARTVVQLPTVAAGLSGLAAHRMVVGINSLLI
LLLVRHVTARAVGGLGTALLFFAATGLGAFLANVLTPTAIRRWGRYATANGALAAAAT
IQVAAAGLLVPVMVVCGFLLGVAGQVVKLCADSAMQMDVDDALRGHVFAVQDALFWVS
YILSITVAAALIPEHGHAPVFVLFGSAIYLAGLVVHTIVGRRGQPVIGR"
gene 41304..41912
/locus_tag="Rv0038"
CDS 41304..41912
/codon_start=1
/transl_table=11
/locus_tag="Rv0038"
/product="Conserved protein"
/note="Rv0038, (MTCY10H4.38), len: 202 aa. Conserved
protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv0038"
/db_xref="EnsemblGenomes-Tr:CCP42760"
/db_xref="GOA:P9WFK5"
/db_xref="InterPro:IPR003774"
/db_xref="UniProtKB/Swiss-Prot:P9WFK5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42760.1"
/translation="MVAPHEDPEDHVAPAAQRVRAGTLLLANTDLLEPTFRRSVIYIV
EHNDGGTLGVVLNRPSETAVYNVLPQWAKLAAKPKTMFIGGPVKRDAALCLAVLRVGA
DPEGVPGLRHVAGRLVMVDLDADPEVLAAAVEGVRIYAGYSGWTIGQLEGEIERDDWI
VLSALPSDVLVGPRADLWGQVLRRQPLPLSLLATHPIDLSRN"
gene complement(42004..42351)
/locus_tag="Rv0039c"
CDS complement(42004..42351)
/codon_start=1
/transl_table=11
/locus_tag="Rv0039c"
/product="Possible conserved transmembrane protein"
/note="Rv0039c, (MTCY21D4.02c, MTCY10H4.39c), len: 115 aa.
Possible conserved transmembrane protein. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0039c"
/db_xref="EnsemblGenomes-Tr:CCP42761"
/db_xref="GOA:P9WM89"
/db_xref="UniProtKB/Swiss-Prot:P9WM89"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42761.1"
/translation="MFLAGVLCMCAAAASALFGSWSLCHTPTADPTALALRAMAPTQL
AAAVMLAAGGVVAVAAPGHTALMVVIVCIAGAVGTLAAGSWQSAQYALRRETASPTAN
CVGSCAVCTQACH"
gene complement(42433..43365)
/gene="mtc28"
/locus_tag="Rv0040c"
CDS complement(42433..43365)
/codon_start=1
/transl_table=11
/gene="mtc28"
/locus_tag="Rv0040c"
/product="Secreted proline rich protein Mtc28 (proline
rich 28 kDa antigen)"
/note="Rv0040c, (MTCY21D4.03c), len: 310 aa.
Mtc28,secreted proline rich 28 kDa antigen protein (has
hydrophobic stretch at N-terminus) (see citation below). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0040c"
/db_xref="EnsemblGenomes-Tr:CCP42762"
/db_xref="GOA:P9WIM9"
/db_xref="InterPro:IPR019674"
/db_xref="PDB:4OL4"
/db_xref="PDB:4PWS"
/db_xref="UniProtKB/Swiss-Prot:P9WIM9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42762.1"
/translation="MIQIARTWRVFAGGMATGFIGVVLVTAGKASADPLLPPPPIPAP
VSAPATVPPVQNLTALPGGSSNRFSPAPAPAPIASPIPVGAPGSTAVPPLPPPVTPAI
SGTLRDHLREKGVKLEAQRPHGFKALDITLPMPPRWTQVPDPNVPDAFVVIADRLGNS
VYTSNAQLVVYRLIGDFDPAEAITHGYIDSQKLLAWQTTNASMANFDGFPSSIIEGTY
RENDMTLNTSRRHVIATSGADKYLVSLSVTTALSQAVTDGPATDAIVNGFQVVAHAAP
AQAPAPAPGSAPVGLPGQAPGYPPAGTLTPVPPR"
gene 43562..46471
/gene="leuS"
/locus_tag="Rv0041"
CDS 43562..46471
/codon_start=1
/transl_table=11
/gene="leuS"
/locus_tag="Rv0041"
/product="Probable leucyl-tRNA synthetase LeuS
(leucine--tRNA ligase) (LEURS)"
/note="Rv0041, (MTCY21D4.04), len: 969 aa. Probable
leucyl-tRNA synthetase, similar to many. Contains PS00178
Aminoacyl-transfer RNA synthetases class-I signature.
Belongs to class-I aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv0041"
/db_xref="EnsemblGenomes-Tr:CCP42763"
/db_xref="GOA:P9WFV1"
/db_xref="InterPro:IPR001412"
/db_xref="InterPro:IPR002302"
/db_xref="InterPro:IPR009008"
/db_xref="InterPro:IPR009080"
/db_xref="InterPro:IPR013155"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR015413"
/db_xref="InterPro:IPR025709"
/db_xref="PDB:5AGR"
/db_xref="PDB:5AGS"
/db_xref="PDB:5AGT"
/db_xref="UniProtKB/Swiss-Prot:P9WFV1"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42763.1"
/translation="MTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWA
RLGTFNVPNPVGSLAPPDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARY
FRMVGRNVLHALGFDAFGLPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRR
SFSTTDVDFYRWTQWIFLQIYNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKL
TAGERADVIDEYRLVYRADSLVNWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQW
MMRITAYADRLLDDLDVLDWPEQVKTMQRNWIGRSTGAVALFSARAASDDGFEVDIEV
FTTRPDTLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRAIA
AKSDLERQESREKTGVFLGSYAINPANGEPVPIFIADYVLAGYGTGAIMAVPGHDQRD
WDFARAFGLPIVEVIAGGNISESAYTGDGILVNSDYLNGMSVPAAKRAIVDRLESAGR
GRARIEFKLRDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSPVLFD
PDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNS
ERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGGAEHAVLHLLYSRFWHKVLYDLGHV
SSREPYRRLVNQGYIQAYAYTDARGSYVPAEQVIERGDRFVYPGPDGEVEVFQEFGKI
GKSLKNSVSPDEICDAYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVV
DEHTGETRVADGVELDIDTLRALHRTIVGVSEDFAALRNNTATAKLIEYTNHLTKKHR
DAVPRAAVEPLVQMLAPLAPHIAEELWLRLGNTTSLAHGPFPKADAAYLVDETVEYPV
QVNGKVRGRVVVAADTDEETLKAAVLTDEKVQAFLAGATPRKVIVVAGRLVNLVI"
gene complement(46581..47207)
/locus_tag="Rv0042c"
CDS complement(46581..47207)
/codon_start=1
/transl_table=11
/locus_tag="Rv0042c"
/product="Possible transcriptional regulatory protein
(probably MarR-family)"
/note="Rv0042c, (MTCY21D4.05c), len: 208 aa. Possible
transcriptional regulatory protein, MarR-family. Some
similarity to Mycobacterium tuberculosis proteins
Rv2327,Rv0880, and Rv1404."
/db_xref="EnsemblGenomes-Gn:Rv0042c"
/db_xref="EnsemblGenomes-Tr:CCP42764"
/db_xref="GOA:P71699"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P71699"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42764.1"
/translation="MSVVRSIGKKMQRISGPNALAVKGRPTQVYGHTHVRLDCRFMAD
SEFTAPEVTQLAEGLHRALSKLISMLRRGDPNGAAAGDLTLAQLSILVTLLDQGPIRM
TDLAAHERVRTPTTTVAIRRLEKIGLVKRSRDPSDLRAVLVDITPQGRAVHGESLANR
RAALAALLSQLPRSDLETLRKALAPLERLASGEPASGPASNSPARKRA"
gene complement(47366..48100)
/locus_tag="Rv0043c"
CDS complement(47366..48100)
/codon_start=1
/transl_table=11
/locus_tag="Rv0043c"
/product="Probable transcriptional regulatory protein
(probably GntR-family)"
/note="Rv0043c, (MTCY21D4.06c), len: 244 aa. Probable
transcriptional regulator, GntR family, similar to
others."
/db_xref="EnsemblGenomes-Gn:Rv0043c"
/db_xref="EnsemblGenomes-Tr:CCP42765"
/db_xref="GOA:P9WMG9"
/db_xref="InterPro:IPR000524"
/db_xref="InterPro:IPR008920"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMG9"
/protein_id="CCP42765.1"
/translation="MPKKYGVKEKDQVVAHILNLLLTGKLRSGDRVDRNEIAHGLGVS
RVPIQEALVQLEHDGIVSTRYHRGAFIERFDVATILEHHELDGLLNGIASARAAANPT
PRILGQLDAVMRSLRNSKESRAFAECVWEYRRTVNDEYAGPRLHATIRASQNLIPRVF
WMTYQNSRDDVLPFYEEENAAIHRREPEAARAACIGRSELMAQTMLAELFRRRVLVPP
EGACPGPFGAPIPGFARSYQPSSPVP"
gene complement(48233..49027)
/locus_tag="Rv0044c"
CDS complement(48233..49027)
/codon_start=1
/transl_table=11
/locus_tag="Rv0044c"
/product="Possible oxidoreductase"
/note="Rv0044c, (MTCY21D4.07c), len: 264 aa. Possible
oxidoreductase, highly similar to
AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase
from Streptomyces lavendulae (264 aa). Also similar to
Mycobacterium tuberculosis proteins e.g. Rv1855c, Rv0953c,
Rv0791c, Rv0132c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0044c"
/db_xref="EnsemblGenomes-Tr:CCP42766"
/db_xref="GOA:P71701"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR022480"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:P71701"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42766.1"
/translation="MTSLVRPDLPVRIGVQLQPQHAPHYRAVRDAVRRCEDIGVDIAF
TWDHFFPLYGDPDGPHFECWTVLGAWAEQTSHIEIGALVTCNSYRNPELLADMARTVD
HISGGRLILGIGSGWKQKDYDEYGYRFGTAGSRLDDLAAALPRIKARLGKLNPPPTRD
IPVLIGGGGERKTLRLVAEYADIWHSFTAGDSYLAKSAVLSTHCSTVGRNPATIERSA
AVDGGGLIASAEALAGLGVTLLTVGCDGPDYDLSAAAALCRWRDGR"
gene complement(49043..49939)
/locus_tag="Rv0045c"
CDS complement(49043..49939)
/codon_start=1
/transl_table=11
/locus_tag="Rv0045c"
/product="Possible hydrolase"
/note="Rv0045c, (MTCY21D4.08c), len: 298 aa. Possible
hydrolase, showing similarity with others. Also similar to
Mycobacterium tuberculosis proteins Rv3473c,
Rv1123c,Rv1938, Rv3617, Rv3670, etc."
/db_xref="EnsemblGenomes-Gn:Rv0045c"
/db_xref="EnsemblGenomes-Tr:CCP42767"
/db_xref="GOA:I6XU97"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6XU97"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42767.1"
/translation="MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALR
WGGSAPRVIFLHGGGQNAHTWDTVIVGLGEPALAVDLPGHGHSAWREDGNYSPQLNSE
TLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLVDVTPSALQRHAELTA
EQRGTVALMHGEREFPSFQAMLDLTIAAAPHRDVKSLRRGVFHNSRRLDNGNWVWRYD
AIRTFGDFAGLWDDVDALSAPITLVRGGSSGFVTDQDTAELHRRATHFRGVHIVEKSG
HSVQSDQPRALIEIVRGVLDTR"
gene complement(50021..51124)
/gene="ino1"
/gene_synonym="tbINO"
/locus_tag="Rv0046c"
CDS complement(50021..51124)
/codon_start=1
/transl_table=11
/gene="ino1"
/gene_synonym="tbINO"
/locus_tag="Rv0046c"
/product="myo-inositol-1-phosphate synthase Ino1 (inositol
1-phosphate synthetase) (D-glucose 6-phosphate
cycloaldolase) (glucose 6-phosphate cyclase)
(glucocycloaldolase)"
/note="Rv0046c, (MTCY21D4.09c), len: 367 aa. Ino1
(alternate gene name: tbINO), myo-inositol-1-phosphate
synthase (see citations below)."
/db_xref="EnsemblGenomes-Gn:Rv0046c"
/db_xref="EnsemblGenomes-Tr:CCP42768"
/db_xref="GOA:P9WKI1"
/db_xref="InterPro:IPR002587"
/db_xref="InterPro:IPR013021"
/db_xref="InterPro:IPR017815"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:1GR0"
/db_xref="UniProtKB/Swiss-Prot:P9WKI1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42768.1"
/translation="MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTS
TVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVI
VQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQC
AIDAGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDR
GVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDH
VGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIG
GPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG"
gene complement(51185..51727)
/locus_tag="Rv0047c"
CDS complement(51185..51727)
/codon_start=1
/transl_table=11
/locus_tag="Rv0047c"
/product="Conserved protein"
/note="Rv0047c, (MTCY21D4.10c), len: 180 aa. Conserved
protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv0047c"
/db_xref="EnsemblGenomes-Tr:CCP42769"
/db_xref="InterPro:IPR005149"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P71704"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42769.1"
/translation="MLELAILGLLIESPMHGYELRKRLTGLLGAFRAFSYGSLYPALR
RMQADGLIAENAAPAGTPVRRARRVYQLTDKGRRRFGELVADTGPHNYTDDGFGVHLA
FFNRTPAEARMRILEGRRRQVEERREGLREAVARASSSFDRYTRQLHQLGLESSEREV
KWLNELIAAERAAPNPAEQT"
gene complement(51828..52697)
/locus_tag="Rv0048c"
CDS complement(51828..52697)
/codon_start=1
/transl_table=11
/locus_tag="Rv0048c"
/product="Possible membrane protein"
/note="Rv0048c, MTCY21D4.11c, len: 289 aa. Possible
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv0048c"
/db_xref="EnsemblGenomes-Tr:CCP42770"
/db_xref="GOA:P9WM87"
/db_xref="InterPro:IPR012551"
/db_xref="UniProtKB/Swiss-Prot:P9WM87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42770.1"
/translation="MAKWLGAPLARGVSTATRAKDSDRQDACRILDDALRDGELSMEE
HRERVSAATKAVTLGDLQRLVADLQVESAPAQMPALKSRAKRTELGLLAAAFVASVLL
GVGIGWGVYGNTRSPLDFTSDPGAKPDGIAPVVLTPPRQLHSLGGLTGLLEQTRKRFG
DTMGYRLVIYPEYASLDRVDPADDRRVLAYTYRGGWGDATSSAKSIADVSVVDLSKFD
AKTAVGIMRGAPETLGLKQSDVKSMYLIVEPVKDPTTPAALSLSLYVSSDYGGGYLVF
AGDGTIKHVSYPS"
gene 52831..53244
/locus_tag="Rv0049"
CDS 52831..53244
/codon_start=1
/transl_table=11
/locus_tag="Rv0049"
/product="Conserved hypothetical protein"
/note="Rv0049, (MTCY21D4.12), len: 137 aa. Conserved
hypothetical protein. A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0049"
/db_xref="EnsemblGenomes-Tr:CCP42771"
/db_xref="InterPro:IPR035169"
/db_xref="UniProtKB/Swiss-Prot:P9WM85"
/protein_id="CCP42771.1"
/translation="MDYTLRRRSLLAEVYSGRTGVSEVCDANPYLLRAAKFHGKPSRV
ICPICRKEQLTLVSWVFGEHLGAVSGSARTAEELILLATRFSEFAVHVVEVCRTCSWN
HLVKSYVLGAARPARPPRGSGGTRTARNGARTASE"
gene 53663..55699
/gene="ponA1"
/locus_tag="Rv0050"
CDS 53663..55699
/codon_start=1
/transl_table=11
/gene="ponA1"
/locus_tag="Rv0050"
/product="Probable bifunctional penicillin-binding protein
1A/1B PonA1 (murein polymerase) (PBP1):
penicillin-insensitive transglycosylase (peptidoglycan
TGASE) + penicillin-sensitive transpeptidase
(DD-transpeptidase)"
/note="Rv0050, (MTCY21D4.13), len: 678 aa. Probable
ponA1,penicillin-binding protein (class A), bienzymatic
protein with transglycosylase and transpeptidase
activities (see Graham & Clark-Curtiss 1999), highly
similar to many (see Billman-Jacobe et al., 1999). Belongs
to the transglycosylase family in the N-terminal section,
and to the transpeptidase family in the C-terminal
section."
/db_xref="EnsemblGenomes-Gn:Rv0050"
/db_xref="EnsemblGenomes-Tr:CCP42772"
/db_xref="GOA:P71707"
/db_xref="InterPro:IPR001264"
/db_xref="InterPro:IPR001460"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR023346"
/db_xref="InterPro:IPR036950"
/db_xref="PDB:5CRF"
/db_xref="PDB:5CXW"
/db_xref="UniProtKB/Swiss-Prot:P71707"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42772.1"
/translation="MVILLPMVTFTMAYLIVDVPKPGDIRTNQVSTILASDGSEIAKI
VPPEGNRVDVNLSQVPMHVRQAVIAAEDRNFYSNPGFSFTGFARAVKNNLFGGDLQGG
STITQQYVKNALVGSAQHGWSGLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRG
AYGISAASKAYFDKPVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMV
ETKALSPNDRAAQVFPETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQTLNT
QGLVVTTTIDPQAQRAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVRAYYGGDNANGF
DFAQAGLQTGSSFKVFALVAALEQGIGLGYQVDSSPLTVDGIKITNVEGEGCGTCNIA
EALKMSLNTSYYRLMLKLNGGPQAVADAAHQAGIASSFPGVAHTLSEDGKGGPPNNGI
VLGQYQTRVIDMASAYATLAASGIYHPPHFVQKVVSANGQVLFDASTADNTGDQRIPK
AVADNVTAAMEPIAGYSRGHNLAGGRDSAAKTGTTQFGDTTANKDAWMVGYTPSLSTA
VWVGTVKGDEPLVTASGAAIYGSGLPSDIWKATMDGALKGTSNETFPKPTEVGGYAGV
PPPPPPPEVPPSETVIQPTVEIAPGITIPIGPPTTITLAPPPPAPPAATPTPPP"
gene 55696..57378
/locus_tag="Rv0051"
CDS 55696..57378
/codon_start=1
/transl_table=11
/locus_tag="Rv0051"
/product="Probable conserved transmembrane protein"
/note="Rv0051, (MTCY21D4.14), len:560 aa. Predicted to be
in the GT-C superfamily of glycosyltransferases (See Liu
and Mushegian, 2003). Probable conserved transmembrane
protein."
/db_xref="EnsemblGenomes-Gn:Rv0051"
/db_xref="EnsemblGenomes-Tr:CCP42773"
/db_xref="GOA:P71708"
/db_xref="InterPro:IPR016570"
/db_xref="InterPro:IPR018584"
/db_xref="UniProtKB/TrEMBL:P71708"
/protein_id="CCP42773.1"
/translation="MTGALSQSSNISPLPLAADLRSADNRDCPSRTDVLGAALANVVG
GPVGRHALIGRTRLMTPLRVMFAIALVFLALGWSTKAACLQSTGTGPGDQRVANWDNQ
RAYYQLCYSDTVPLYGAELLSQGKFPYKSSWIETDSNGTPQLRYDGQIAVRYMEYPVL
TGIYQYLSMAIAKTYTALSKVAPLPVVAEVVMFFNVAAFGLALAWLTTVWATSGLAGR
RIWDAALVAASPLVIFQIFTNFDALATGLATSGLLAWARRRPVLAGVLIGLGSAAKLY
PLLFLYPLLLLGIRAGRLNALARTMAAAAATWLLVNLPVMLLFPRGWSEFFRLNTRRG
DDMDSLYNVVKSFTGWRGFDPTLGFWEPPLVLNTVVTLLFVLCCAAIAYIALTAPHRP
RVAQLTFLTVASFLLVNKVWSPQFSLWLVPLAVLALPHRRILLAWMTIDALVWVPRMY
YLYGNPSRSLPEQWFTTTVLLRDIAVMVLCGLVVWQIYRPGRDLVRTGGPGALPACGG
VDDPVGGVFANAADAPPGRLPSWLRPRLGDEHARERTPDAGRDRTFSGQHRA"
gene 57410..57973
/locus_tag="Rv0052"
CDS 57410..57973
/codon_start=1
/transl_table=11
/locus_tag="Rv0052"
/product="Conserved protein"
/note="Rv0052, (MTCY21D4.15), len: 187 aa. Conserved
protein, similar to others including Rv1930c from
Mycobacterium tuberculosis (174 aa). May be a membrane
protein."
/db_xref="EnsemblGenomes-Gn:Rv0052"
/db_xref="EnsemblGenomes-Tr:CCP42774"
/db_xref="InterPro:IPR002818"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/TrEMBL:I6Y6S3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42774.1"
/translation="MPSFDVVFVGHRRGEVRSDNAMLGLLCDAAFDELTRPDVVIFPG
GIGTRTLIHDQTVLDWVREAHRHTLLTTSVCTGGLVLAAAGLLNGLTATTHWRVQDLF
NSLGARYVPQRVVEHLPERVITAAGVSSGIDMGLRLVELLVSREAAEASQLMIEYDPQ
PPVDAGSLAKASPATHRLALEFYQHRL"
gene 58192..58482
/gene="rpsF"
/locus_tag="Rv0053"
CDS 58192..58482
/codon_start=1
/transl_table=11
/gene="rpsF"
/locus_tag="Rv0053"
/product="30S ribosomal protein S6 RpsF"
/note="Rv0053, (MTCY21D4.16), len: 96 aa. rpsF, 30S
ribosomal protein S6, highly similar to many. Contains
PS01048 Ribosomal protein S6 signature. Belongs to the S6P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0053"
/db_xref="EnsemblGenomes-Tr:CCP42775"
/db_xref="GOA:P9WH31"
/db_xref="InterPro:IPR000529"
/db_xref="InterPro:IPR014717"
/db_xref="InterPro:IPR020814"
/db_xref="InterPro:IPR020815"
/db_xref="InterPro:IPR035980"
/db_xref="UniProtKB/Swiss-Prot:P9WH31"
/inference="protein motif:PROSITE:PS01048"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42775.1"
/translation="MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWG
KRRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH"
gene 58586..59080
/gene="ssb"
/locus_tag="Rv0054"
CDS 58586..59080
/codon_start=1
/transl_table=11
/gene="ssb"
/locus_tag="Rv0054"
/product="Single-strand binding protein Ssb
(helix-destabilizing protein)"
/note="Rv0054, (MTCY21D4.17), len: 164 aa.
ssb,single-strand binding protein (see Mizrahi & Andersen
1998), highly similar to others. Belongs to the SSB
family."
/db_xref="EnsemblGenomes-Gn:Rv0054"
/db_xref="EnsemblGenomes-Tr:CCP42776"
/db_xref="GOA:P9WGD5"
/db_xref="InterPro:IPR000424"
/db_xref="InterPro:IPR011344"
/db_xref="InterPro:IPR012340"
/db_xref="PDB:1UE1"
/db_xref="PDB:1UE5"
/db_xref="PDB:1UE6"
/db_xref="PDB:1UE7"
/db_xref="UniProtKB/Swiss-Prot:P9WGD5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42776.1"
/translation="MAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQT
GEWKDGEALFLRCNIWREAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVE
VDEIGPSLRYATAKVNKASRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDD
EPPF"
gene 59122..59376
/gene="rpsR1"
/gene_synonym="rpsR"
/locus_tag="Rv0055"
CDS 59122..59376
/codon_start=1
/transl_table=11
/gene="rpsR1"
/gene_synonym="rpsR"
/locus_tag="Rv0055"
/product="30S ribosomal protein S18-1 RpsR1"
/note="Rv0055, (MTCY21D4.18), len: 84 aa. rpsR1, 30S
ribosomal protein S18-1. Belongs to the S18P family of
ribosomal proteins. Note that previously known as rpsR."
/db_xref="EnsemblGenomes-Gn:Rv0055"
/db_xref="EnsemblGenomes-Tr:CCP42777"
/db_xref="GOA:P9WH49"
/db_xref="InterPro:IPR001648"
/db_xref="InterPro:IPR018275"
/db_xref="InterPro:IPR036870"
/db_xref="UniProtKB/Swiss-Prot:P9WH49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42777.1"
/translation="MAKSSKRRPAPEKPVKTRKCVFCAKKDQAIDYKDTALLRTYISE
RGKIRARRVTGNCVQHQRDIALAVKNAREVALLPFTSSVR"
gene 59409..59867
/gene="rplI"
/locus_tag="Rv0056"
CDS 59409..59867
/codon_start=1
/transl_table=11
/gene="rplI"
/locus_tag="Rv0056"
/product="50S ribosomal protein L9 RplI"
/note="Rv0056, (MTCY21D4.19), len: 152 aa. rplI, 50S
ribosomal protein L9. Contains PS00651 Ribosomal protein
L9 signature. Belongs to the L9P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv0056"
/db_xref="EnsemblGenomes-Tr:CCP42778"
/db_xref="GOA:P9WH79"
/db_xref="InterPro:IPR000244"
/db_xref="InterPro:IPR009027"
/db_xref="InterPro:IPR020069"
/db_xref="InterPro:IPR020070"
/db_xref="InterPro:IPR020594"
/db_xref="InterPro:IPR036791"
/db_xref="InterPro:IPR036935"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH79"
/inference="protein motif:PROSITE:PS00651"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42778.1"
/translation="MKLILTADVDHLGSIGDTVEVKDGYGRNFLLPRGLAIVASRGAQ
KQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVA
AIKKAGGPNLDKRIVRLPKTHIKAVGTHFVSVHLHPEIDVEVSLDVVAQS"
gene 59896..60417
/locus_tag="Rv0057"
CDS 59896..60417
/codon_start=1
/transl_table=11
/locus_tag="Rv0057"
/product="Hypothetical protein"
/note="Rv0057, (MTCY21D4.20), len: 173 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0057"
/db_xref="EnsemblGenomes-Tr:CCP42779"
/db_xref="UniProtKB/Swiss-Prot:P9WM77"
/protein_id="CCP42779.1"
/translation="MPVVTAVGRRRGFAMPWVSTARSGAVMLANYSAGVCGRVSSPGL
NVRKMCLKANTPGAVTWLDTPKRFLSTQTASRCMAVNSSDVVTGRIDPQVLHTPLNTD
VDGYAHAMHSSINSGPLEYLPATFSVFPALGDVGDLGGGVGAATYALDRLSNMRSGAC
VGGGESPWRSLMT"
gene 60396..63020
/gene="dnaB"
/locus_tag="Rv0058"
CDS 60396..63020
/codon_start=1
/transl_table=11
/gene="dnaB"
/locus_tag="Rv0058"
/product="Probable replicative DNA helicase DnaB"
/note="Rv0058, (MTV030.01, MTCY21D4.21), len: 874 aa.
Probable dnaB, replicative DNA helicase. Contains an
intein (position 61630..62838) similar to, and in the same
position as, those in Sycnechocystis and Rhodothermus
marinus (see citation below) and C-terminal extein
(position 62839..63015) similar to many dnaB proteins.
This protein undergoes a protein self splicing that
involves a post-translational excision of the intervening
region (intein) followed by peptide ligation. Belongs to
the helicase family, DNAB subfamily. In the intein
section; belongs to the homing endonuclease family."
/db_xref="EnsemblGenomes-Gn:Rv0058"
/db_xref="EnsemblGenomes-Tr:CCP42780"
/db_xref="GOA:P9WMR3"
/db_xref="InterPro:IPR003586"
/db_xref="InterPro:IPR003587"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004042"
/db_xref="InterPro:IPR004860"
/db_xref="InterPro:IPR006141"
/db_xref="InterPro:IPR006142"
/db_xref="InterPro:IPR007692"
/db_xref="InterPro:IPR007693"
/db_xref="InterPro:IPR007694"
/db_xref="InterPro:IPR016136"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR027434"
/db_xref="InterPro:IPR030934"
/db_xref="InterPro:IPR036185"
/db_xref="InterPro:IPR036844"
/db_xref="PDB:2R5U"
/db_xref="UniProtKB/Swiss-Prot:P9WMR3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42780.1"
/translation="MAVVDDLAPGMDSSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDA
IADVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRRIGGAPY
LHTLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAGAEGADVAEVVDRAQ
AEIYDVADRRLSEDFVALEDLLQPTMDEIDAIASSGGLARGVATGFTELDEVTNGLHP
GQMVIVAARPGVGKSTLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKL
SDMRSGRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKANLKLIV
VDYLQLMTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLNRGPEQRTDKKPML
ADLRESGCLTASTRILRADTGAEVAFGELMRSGERPMVWSLDERLRMVARPMINVFPS
GRKEVFRLRLASGREVEATGSHPFMKFEGWTPLAQLKVGDRIAAPRRVPEPIDTQRMP
ESELISLARMIGDGSCLKNQPIRYEPVDEANLAAVTVSAAHSDRAAIRDDYLAARVPS
LRPARQRLPRGRCTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAG
GSVRWDPTNGQGRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRLHIHG
AKDQVRFLRHVGVHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWAQVRNRLSAKQMM
DIQLHEPTMWKHSPSRSRPHRAEARIEDRAIHELARGDAYWDTVVEITSIGDQHVFDG
TVSGTHNFVANGISLHNSLEQDADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTK
TVTVAHQLHLSRFANMAR"
gene 63200..63892
/locus_tag="Rv0059"
CDS 63200..63892
/codon_start=1
/transl_table=11
/locus_tag="Rv0059"
/product="Hypothetical protein"
/note="Rv0059, (MTV030.02), len: 230 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0059"
/db_xref="EnsemblGenomes-Tr:CCP42781"
/db_xref="InterPro:IPR029494"
/db_xref="UniProtKB/TrEMBL:O53604"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42781.1"
/translation="MITRYKPESGFVARSGGPDRKRPHDWIVWHFTHADNLPGIITAG
RLLADSAVTPTTEVAYNPVKELRRHKVVAPDSRYPASMASDHVPFYIAARSPMLYVVC
KGHSGYSGGAGPLVHLGVALGDIIDADLTWCASDGNAAASYTKFSRQVDTLGTFVDFD
LLCQRQWHNTDDDPNRQSRRAAEILVYGHVPFELVSYVCCYNTETMTRVRTLLDPVGG
VRKYVIKPGMYY"
gene 63909..64967
/locus_tag="Rv0060"
CDS 63909..64967
/codon_start=1
/transl_table=11
/locus_tag="Rv0060"
/product="Conserved hypothetical protein"
/note="Rv0060, (MTV030.03), len: 352 aa. Conserved
hypothetical protein."
/db_xref="EnsemblGenomes-Gn:Rv0060"
/db_xref="EnsemblGenomes-Tr:CCP42782"
/db_xref="GOA:O53605"
/db_xref="InterPro:IPR002589"
/db_xref="PDB:5M3I"
/db_xref="UniProtKB/TrEMBL:O53605"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42782.1"
/translation="MITYGSGDLLRADTEALVNTVNCVGVMGKGIALQFKRRYPEMFT
AYEKACKRGEVTIGKMFVVDTGQLDGPKHIINFPTKKHWRAPSKLAYIDAGLIDLIRV
IRELNIASVAVPPLGVGNGGLDWEDVEQRLVSAFQQLPDVDAVIYPPSGGSRAIEGVE
GLRMTWGRAVILEAMRRYLQQRRAMEPWEDPAGISHLEIQKLMYFANEADPDLALDFT
PGRYGPYSERVRHLLQGMEGAFTVGLGDGTARVLANQPISLTTKGTDAITDYLATDAA
ADRVSAAVDTVLRVIEGFEGPYGVELLASTHWVATREGAKEPATAAAAVRKWTKRKGR
IYSDDRIGVALDRILMTA"
gene complement(65012..65350)
/locus_tag="Rv0061c"
CDS complement(65012..65350)
/codon_start=1
/transl_table=11
/locus_tag="Rv0061c"
/product="Hypothetical protein"
/note="Rv0061c, len: 112 aa. Conserved hypothetical
protein supported by RNA-seq data. Similar to MMAR_3839,
76% identity in 112 aa overlap. Replaces questionable ORF
Rv0061 (MTV030.04)."
/db_xref="EnsemblGenomes-Gn:Rv0061c"
/db_xref="EnsemblGenomes-Tr:CCP42783"
/db_xref="UniProtKB/TrEMBL:I6X8E6"
/protein_id="CCP42783.1"
/translation="MKLKFARLSTAILGCAAALVFPASVASADPPDPHQPDMTKGYCP
GGRWGFGDLAVCDGEKYPDGSFWHQWMQTWFTGPQFYFDCVSGGEPLPGPPPPGGCGG
AIPSEQPNAP"
gene 65552..66694
/gene="celA1"
/gene_synonym="cel6"
/gene_synonym="celA"
/locus_tag="Rv0062"
CDS 65552..66694
/codon_start=1
/transl_table=11
/gene="celA1"
/gene_synonym="cel6"
/gene_synonym="celA"
/locus_tag="Rv0062"
/product="Possible cellulase CelA1 (endoglucanase)
(endo-1,4-beta-glucanase) (FI-cmcase) (carboxymethyl
cellulase)"
/note="Rv0062, (MTV030.05), len: 380 aa. Possible
celA1,cellulase, similar to many. Seems to belong to
cellulase family B (family 6 of glycosyl hydrolases). Note
that previously known as celA."
/db_xref="EnsemblGenomes-Gn:Rv0062"
/db_xref="EnsemblGenomes-Tr:CCP42784"
/db_xref="GOA:Q79G13"
/db_xref="InterPro:IPR016288"
/db_xref="InterPro:IPR036434"
/db_xref="PDB:1UOZ"
/db_xref="PDB:1UP0"
/db_xref="PDB:1UP2"
/db_xref="PDB:1UP3"
/db_xref="UniProtKB/TrEMBL:Q79G13"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42784.1"
/translation="MTRRTGQRWRGTLPGRRPWTRPAPATCRRHLAFVELRHYFARVM
SSAIGSVARWIVPLLGVAAVASIGVIADPVRVVRAPALILVDAANPLAGKPFYVDPAS
AAMVAARNANPPNAELTSVANTPQSYWLDQAFPPATVGGTVARYTGAAQAAGAMPVLT
LYGIPHRDCGSYASGGFATGTDYRGWIDAVASGLGSSPATIIVEPDALAMADCLSPDQ
RQERFDLVRYAVDTLTRDPAAAVYVDAGHSRWLSAEAMAARLNDVGVGRARGFSLNVS
NFYTTDEEIGYGEAISGLTNGSHYVIDTSRNGAGPAPDAPLNWCNPSGRALGAPPTTA
TAGAHADAYLWIKRPGESDGTCGRGEPQAGRFVSQYAIDLAHNAGQ"
gene 66923..68362
/locus_tag="Rv0063"
CDS 66923..68362
/codon_start=1
/transl_table=11
/locus_tag="Rv0063"
/product="Possible oxidoreductase"
/note="Rv0063, (MTV030.06), len: 479 aa. Possible
oxidoreductase, similar to many. Similar to Mycobacterium
tuberculosis proteins e.g. Rv3107c, Rv1257c, etc. Contains
PS00862 Oxygen oxidoreductases covalent FAD-binding site."
/db_xref="EnsemblGenomes-Gn:Rv0063"
/db_xref="EnsemblGenomes-Tr:CCP42785"
/db_xref="GOA:O53608"
/db_xref="InterPro:IPR006093"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR012951"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016167"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:O53608"
/inference="protein motif:PROSITE:PS00862"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42785.1"
/translation="MAREISRQTFLRGAAGALAAGAVFGSVRATADPAASGWEALSSA
LGGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAFAAANNLKVAP
RGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTVTPATGLYAMHQVLAAAGRG
IPTGTCPTVGVAGHALGGGLGANSRHAGLLCDQLTSASVVLPSGQAVTASATDHPDLF
WALRGGGGGNFGVTTSLTFATFPSGDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSW
ALADATVDPLGTHCRILATCPAGSGGSVAAAIVSAVGTQPTGTENHTFNYLDLVRYLA
VGNLNPSPLGYVGGSDVFTTITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVS
PGATAFPWRRQSALVQWYVETSGSPSEATSWLNTAHQAVRAYSVGGYVNYLEVNQPPA
RYFGPNLSRLSAVRQKYDPSRVMFSGLNF"
gene 68620..71559
/locus_tag="Rv0064"
CDS 68620..71559
/codon_start=1
/transl_table=11
/locus_tag="Rv0064"
/product="Probable conserved transmembrane protein"
/note="Rv0064, (MTV030.07), len: 979 aa. Probable
conserved transmembrane protein, similar to many. Contains
probable coiled-coil domain from aa 948 to 976."
/db_xref="EnsemblGenomes-Gn:Rv0064"
/db_xref="EnsemblGenomes-Tr:CCP42786"
/db_xref="GOA:P9WFL5"
/db_xref="InterPro:IPR005372"
/db_xref="UniProtKB/Swiss-Prot:P9WFL5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42786.1"
/translation="METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWL
WFGEVGFRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDPVA
PLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIVDPEFGYDIGF
FVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAARVQLAVFAG
AVVLLKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFT
AIFLRDLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATRE
AYRIGGDWVQYRSYPGIGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFS
FAEILDIDRYRIDGELQDYIVGVRELSPKSLTGNQTDWINKHTVYTHGNGFVAAPANR
VNAAARGAENISDSNSGYPIYAVSDIASLGSGRQVIPVEQPRVYYGEVIAQADPDYAI
VGGAPGSAPREYDTDTSKYTYTGAGGVSIGNWFNRTVFATKVAQHKFLFSREIGSESK
VLIHRDPKERVQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPV
TSPTGIVRQGKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSED
QIPDELRAHFRYPEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNNANATQPP
FYVLVGDQQSAQPSFRLASAMVGYNREFLSAYISAHSDPANYGKLTVLELPTDTLTQG
PQQIQNSMISDTRVASERTLLERSNRIHYGNLLSLPIADGGVLYVEPLYTERISTSPS
SSTFPQLSRVLVSVREPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATARGGDAASAP
PPGAGGPAPPQAVPPPRTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAID
AAETPGG"
gene 71589..71828
/gene="vapB1"
/locus_tag="Rv0064A"
CDS 71589..71828
/codon_start=1
/transl_table=11
/gene="vapB1"
/locus_tag="Rv0064A"
/product="Possible antitoxin VapB1"
/note="Rv0064A, len: 79 aa. Possible vapB1, antitoxin,
part of toxin-antitoxin (TA) operon with Rv0065 (See Arcus
et al., 2005; Pandey and Gerdes, 2005). Weakly similar to
others in Mycobacterium tuberculosis e.g. Rv0300 (73
aa),Rv1721c (75 aa)"
/db_xref="EnsemblGenomes-Gn:Rv0064A"
/db_xref="EnsemblGenomes-Tr:CCP42787"
/db_xref="GOA:P0CW29"
/db_xref="InterPro:IPR010985"
/db_xref="UniProtKB/Swiss-Prot:P0CW29"
/protein_id="CCP42787.1"
/translation="MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRD
KAEAIEILEQALASTASPGISRETIEASRRELRGG"
gene 71821..72222
/gene="vapC1"
/locus_tag="Rv0065"
CDS 71821..72222
/codon_start=1
/transl_table=11
/gene="vapC1"
/locus_tag="Rv0065"
/product="Possible toxin VapC1"
/note="Rv0065, (MTV030.08), len: 133 aa. Possible
vapC1,toxin, part of toxin-antitoxin (TA) operon with
Rv0064A,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to several others in
Mycobacterium tuberculosis: Rv0960 (127 aa), Rv1720c (129
aa), and Rv0549c (137 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0065"
/db_xref="EnsemblGenomes-Tr:CCP42788"
/db_xref="GOA:P9WFC1"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFC1"
/protein_id="CCP42788.1"
/translation="MDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEV
GHALRRAVLSDEISEEQARAALDALPYLIDNRYPHSPRLIEYTWQLRHNVTFYDALYV
ALATALDVPLLTGDSRLAAAPGLPCEIKLVR"
gene complement(72274..74511)
/gene="icd2"
/locus_tag="Rv0066c"
CDS complement(72274..74511)
/codon_start=1
/transl_table=11
/gene="icd2"
/locus_tag="Rv0066c"
/product="Probable isocitrate dehydrogenase [NADP] Icd2
(oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH)
(IDP)"
/note="Rv0066c, (MTV030.09c), len: 745 aa. Probable
icd2,isocitrate dehydrogenase NADP-dependent. Belongs to
the monomeric-type family of IDH. Note that in H37Rv,
Rv0066c is named icd2 and Rv3339c is icd1 while in CDC1551
and Erdman strains, Rv0066c is icd1 and Rv3339c is icd2."
/db_xref="EnsemblGenomes-Gn:Rv0066c"
/db_xref="EnsemblGenomes-Tr:CCP42789"
/db_xref="GOA:O53611"
/db_xref="InterPro:IPR004436"
/db_xref="PDB:5KVU"
/db_xref="UniProtKB/TrEMBL:O53611"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42789.1"
/translation="MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDI
SVAARILAEFPDYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKEL
QDKGYAVPDYPADPKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKH
PHSMGEWSMASRTHVAHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPL
DDGDVIDSMFMSKKALCDFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIF
YKDAFAKHQELFDDLGVNVNNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMV
DSARGISNFHSPSDVIVDASMPAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEII
NFCKTNGQFDPTTMGTVPNVGLMAQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLT
ENVEAGDIWRMCIVKDAPIRDWVKLAVTRARISGMPVLFWLDPYRPHENELIKKVKTY
LKDHDTEGLDIQIMSQVRSMRYTCERLVRGLDTIAATGNILRDYLTDLFPILELGTSA
KMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEENHLRWDSLGEFLALGAGFEDIGIKT
GNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNRGSQFYLAMYWAQELAAQTDDQQ
LAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYAPDSDMTTAVMRPSKTFNAAL
EAVQG"
gene complement(74629..75198)
/locus_tag="Rv0067c"
CDS complement(74629..75198)
/codon_start=1
/transl_table=11
/locus_tag="Rv0067c"
/product="Possible transcriptional regulatory protein
(possibly TetR-family)"
/note="Rv0067c, (MTV030.10c), len: 189 aa. Possible
transcriptional regulator, highly similar to many.
Contains probable helix-turn-helix motif from aa 34 to 55
(Score 1523, +4.37 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0067c"
/db_xref="EnsemblGenomes-Tr:CCP42790"
/db_xref="GOA:O53612"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O53612"
/protein_id="CCP42790.1"
/translation="MAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAG
VGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGA
TDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLV
GCQAMQSYNAELAAKVTDVALDGLRANRK"
gene 75301..76212
/locus_tag="Rv0068"
CDS 75301..76212
/codon_start=1
/transl_table=11
/locus_tag="Rv0068"
/product="Probable oxidoreductase"
/note="Rv0068, (MTV030.11), len: 303 aa. Probable
oxidoreductase, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv0068"
/db_xref="EnsemblGenomes-Tr:CCP42791"
/db_xref="GOA:O53613"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53613"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42791.1"
/translation="MTKWTAADIPDQTGRTAVITGANTGLGFETAAALAAHGAHVVLA
VRNLDKGKQAAARITEATPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAG
VMYTPRQTTADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIH
FDDLQWERRYRRVAAYGQAKLANLLFTYELQRRLAPGGTTIAVASHPGVSNTEVVRNM
PRPLVAVAAILAPLMQDAELGALPTLRAATDPAVRGGQYFGPDGFGEIRGYPKVVASS
AQSHDEQLQRRLWAVSEELTGVVYPVG"
gene complement(76237..77622)
/gene="sdaA"
/locus_tag="Rv0069c"
CDS complement(76237..77622)
/codon_start=1
/transl_table=11
/gene="sdaA"
/locus_tag="Rv0069c"
/product="Probable L-serine dehydratase SdaA (L-serine
deaminase) (SDH) (L-SD)"
/note="Rv0069c, (MTV030.12c), len: 461 aa. Probable
sdaA,L-serine dehydratase. Belongs to the iron-sulfur
dependent L-serine dehydratase family. Cofactor:
iron-sulfur (4FE-4S) (probable)."
/db_xref="EnsemblGenomes-Gn:Rv0069c"
/db_xref="EnsemblGenomes-Tr:CCP42792"
/db_xref="GOA:P9WGT5"
/db_xref="InterPro:IPR004644"
/db_xref="InterPro:IPR005130"
/db_xref="InterPro:IPR005131"
/db_xref="InterPro:IPR029009"
/db_xref="UniProtKB/Swiss-Prot:P9WGT5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42792.1"
/translation="MTISVFDLFTIGIGPSSSHTVGPMRAANQFVVALRRRGHLDDLE
AMRVDLFGSLAATGAGHGTMSAILLGLEGCQPETITTEHKERRLAEIAASGVTRIGGV
IPVPLTERDIDLHPDIVLPTHPNGMTFTAAGPHGRVLATETYFSVGGGFIVTEQTSGN
SGQHPCSVALPYVSAQELLDICDRLDVSISEAALRNETCCRTENEVRAALLHLRDVMV
ECEQRSIAREGLLPGGLRVRRRAKVWYDRLNAEDPTRKPEFAEDWVNLVALAVNEENA
SGGRVVTAPTNGAAGIVPAVLHYAIHYTSAGAGDPDDVTVRFLLTAGAIGSLFKERAS
ISGAEVGCQGEVGSAAAMAAAGLAEILGGTPRQVENAAEIAMEHSLGLTCDPIAGLVQ
IPCIERNAISAGKAINAARMALRGDGIHRVTLDQVIDTMRATGADMHTKYKETSAGGL
AINVAVNIVEC"
gene complement(77619..78896)
/gene="glyA2"
/locus_tag="Rv0070c"
CDS complement(77619..78896)
/codon_start=1
/transl_table=11
/gene="glyA2"
/locus_tag="Rv0070c"
/product="Serine hydroxymethyltransferase GlyA2 (serine
methylase 2) (SHMT 2)"
/note="Rv0070c, (MTV030.13c), len: 425 aa. glyA2, serine
hydroxymethyltransferase. Contains PS00096 Serine
hydroxymethyltransferase pyridoxal-phosphate attachment
site. Belongs to the ShmT family. Cofactor: pyridoxal
phosphate."
/db_xref="EnsemblGenomes-Gn:Rv0070c"
/db_xref="EnsemblGenomes-Tr:CCP42793"
/db_xref="GOA:P9WGI7"
/db_xref="InterPro:IPR001085"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR019798"
/db_xref="InterPro:IPR039429"
/db_xref="UniProtKB/Swiss-Prot:P9WGI7"
/inference="protein motif:PROSITE:PS00096"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42793.1"
/translation="MNTLNDSLTAFDPDIAALIDGELRRQESGLEMIASENYAPLAVM
QAQGSVLTNKYAEGYPGRRYYGGCEFVDGVEQLAIDRVKALFGAEYANVQPHSGATAN
AATMHALLNPGDTILGLSLAHGGHLTHGMRINFSGKLYHATAYEVSKEDYLVDMDAVA
EAARTHRPKMIIAGWSAYPRQLDFARFRAIADEVDAVLMVDMAHFAGLVAAGVHPSPV
PHAHVVTSTTHKTLGGPRGGIILCNDPAIAKKINSAVFPGQQGGPLEHVIAAKATAFK
MAAQPEFAQRQQRCLDGARILAGRLTQPDVAERGIAVLTGGTDVHLVLVDLRDAELDG
QQAEDRLAAVDITVNRNAVPFDPRPPMITSGLRIGTPALAARGFSHNDFRAVADLIAA
ALTATNDDQLGPLRAQVQRLAARYPLYPELHRT"
gene 79486..80193
/locus_tag="Rv0071"
CDS 79486..80193
/codon_start=1
/transl_table=11
/locus_tag="Rv0071"
/product="Possible maturase"
/note="Rv0071, (MTV030.14), len: 235 aa. Possible
maturase,similar to many proteins of the group II intron
maturase family. Contains 5 VDP repeats at N-terminus,
these are also found in two Streptococcus plasmid
hypothetical proteins Q52246|X17092 and Q54942|X66468."
/db_xref="EnsemblGenomes-Gn:Rv0071"
/db_xref="EnsemblGenomes-Tr:CCP42794"
/db_xref="InterPro:IPR000477"
/db_xref="UniProtKB/TrEMBL:O53616"
/protein_id="CCP42794.1"
/translation="MSSITVSVDPVDPVDPVDPVDPVDAVVAAGSDGLTVARIESEIG
ALEFLNELRTELKSGQFRPQPVRERKIPKPGGLGKVRRLGIPTVADRVVQAALKLVLE
PIFETDFEPVSYGFRPARRAHDTIAEIHLFGTQEYRWVLDADIKACFDRIDHADLMDR
VRHRIKDKRVLRLVNWQRIRHRWNWTDVRRWLTDPTGRWHPISADGITLFNPAAVPIR
RYRYRGNTIPTPWTQAV"
repeat_region 79507..79551
/locus_tag="Rv0071"
/note="5 x 9 bp GTGGACCCG repeats"
repeat_region 80236..80550
/note="(MTV030.15), len: 315 nt. Probable REP'-1
pseudogene fragment, similar to many Mycobacterium
tuberculosis proteins inside REP13E12 elements e.g.
Q50655|Z95390|MTCY13E12.20 (317 aa), FASTA scores; opt:
324 E(): 6.8e-17, 43.4% identity in 99 aa overlap, but no
possible startsite."
gene 80624..81673
/locus_tag="Rv0072"
CDS 80624..81673
/codon_start=1
/transl_table=11
/locus_tag="Rv0072"
/product="Probable glutamine-transport transmembrane
protein ABC transporter"
/note="Rv0072, (MTV030.16), len: 349 aa. Probable
glutamine-transport transmembrane protein ABC-transporter
(see citation below). Note that supposed act with near ORF
Rv0073|MTV030.17 ATP-binding protein ABC-transporter."
/db_xref="EnsemblGenomes-Gn:Rv0072"
/db_xref="EnsemblGenomes-Tr:CCP42795"
/db_xref="GOA:P9WG17"
/db_xref="UniProtKB/Swiss-Prot:P9WG17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42795.1"
/translation="MLFAALRDMQWRKRRLVITIISTGLIFGMTLVLTGLANGFRVEA
RHTVDSMGVDVFVVRSGAAGPFLGSIPFPDVDLARVAAEPGVMAAAPLGSVGTIMKEG
TSTRNVTVFGAPEHGPGMPRVSEGRSPSKPDEVAASSTMGRHLGDTVEVGARRLRVVG
IVPNSTALAKIPNVFLTTEGLQKLAYNGQPNITSIGIIGMPRQLPEGYQTFDRVGAVN
DLVRPLKVAVNSISIVAVLLWIVAVLIVGSVVYLSALERLRDFAVFKAIGTPTRSIMA
GLALQALVIALLAAVVGVVLAQVLAPLFPMIVAVPVGAYLALPVAAIVIGLFASVAGL
KRVVTVDPAQAFGGP"
gene 81676..82668
/locus_tag="Rv0073"
CDS 81676..82668
/codon_start=1
/transl_table=11
/locus_tag="Rv0073"
/product="Probable glutamine-transport ATP-binding protein
ABC transporter"
/note="Rv0073, (MTV030.17), len: 330 aa. Probable
glutamine-transport ATP-binding protein ABC-transporter
(see citation below), similar to many ATP-binding
proteins. Contains PS00017 ATP/GTP-binding site motif A
(P-loop),PS00211 ABC transporters family signature, and
PS00889 Cyclic nucleotide-binding domain signature 2.
Belongs to the ATP-binding transport protein family (ABC
transporters). Note that supposed act with near ORF
Rv0072|MTV030.16 transmembrane ABC-transporter."
/db_xref="EnsemblGenomes-Gn:Rv0073"
/db_xref="EnsemblGenomes-Tr:CCP42796"
/db_xref="GOA:P9WQK5"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR018488"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQK5"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00889"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42796.1"
/translation="MGDLSIQNLVVEYYSGGYALRPINGLNLDVAAGSLVMLLGPSGC
GKTTLLSCLGGILRPKSGAIKFDEVDITTLQGAELANYRRNKVGIVFQAFNLVPSLTA
VENVMVPLRSAGMSRRASRRRAEELLARVNLAERMNHRPGDLSGGQQQRVAVARAIAL
DPPLILADEPTAHLDFIQVEEVLRLIRELADGERVVVVATHDSRMLPMADRVVELTPD
FAETNRPPETVHLQAGEVLFEQSTMGDLIYVVSEGEFEIVHELADGGEELVKVAGPGD
YFGEIGVLFHLPRSATVRARSDATAVGYTVQAFRERLGVGGLRDLIEHRALAND"
gene 82748..83983
/locus_tag="Rv0074"
CDS 82748..83983
/codon_start=1
/transl_table=11
/locus_tag="Rv0074"
/product="Conserved protein"
/note="Rv0074, (MTV030.18), len: 411 aa. Conserved
protein,similar to many."
/db_xref="EnsemblGenomes-Gn:Rv0074"
/db_xref="EnsemblGenomes-Tr:CCP42797"
/db_xref="GOA:O53619"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR011059"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/TrEMBL:O53619"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42797.1"
/translation="MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRIS
AVDFAGSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAGDPHAVLVGRARR
HAAAALRSGITTIRDLGDRDYAALALREEYRQKTTVGPELVVSGPPLTRSGGHCWFLG
GVADSVEELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQ
VGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVWCGMTI
PRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSR
HGFTSTEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVW
RSGTQVPLQASAVGYNTPS"
gene 83996..85168
/locus_tag="Rv0075"
CDS 83996..85168
/codon_start=1
/transl_table=11
/locus_tag="Rv0075"
/product="Probable aminotransferase"
/note="Rv0075, (MTV030.19), len: 390 aa. Probable
aminotransferase, similar to many class-II
pyridoxal-phosphate-dependent aminotransferases (MALY/PATB
subfamily). Also similar to other proteins from
Mycobacterium tuberculosis e.g. Rv2294, Rv0858c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0075"
/db_xref="EnsemblGenomes-Tr:CCP42798"
/db_xref="GOA:O53620"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/TrEMBL:O53620"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42798.1"
/translation="MQDSIFNLLTEEQLRGRNTLKWNYFGPDVVPLWLAEMDFPTAPA
VLDGVRACVDNEEFGYPPLGEDSLPRATADWCRQRYGWCPRPDWVRVVPDVLKGMEVV
VEFLTRPESPVALPVPAYMPFFDVLHVTGRQRVEVPMVQQDSGRYLLDLDALQAAFVR
GAGSVIICNPNNPLGTAFTEAELRAIVDIAARHGARVIADEIWAPVVYGSRHVAAASV
SEAAAEVVVTLVSASKGWNLPGLMCAQVILSNRRDAHDWDRINMLHRMGASTVGIRAN
IAAYHHGESWLDELLPYLRANRDHLARALPELAPGVEVNAPDGTYLSWVDFRALALPS
EPAEYLLSKAKVALSPGIPFGAAVGSGFARLNFATTRAILDRAIEAIAAALRDIID"
gene complement(85183..85572)
/locus_tag="Rv0076c"
CDS complement(85183..85572)
/codon_start=1
/transl_table=11
/locus_tag="Rv0076c"
/product="Probable membrane protein"
/note="Rv0076c, (MTV030.20c), len: 129 aa. Probable
membrane protein, with membrane-spanning domain at
C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0076c"
/db_xref="EnsemblGenomes-Tr:CCP42799"
/db_xref="GOA:O53621"
/db_xref="UniProtKB/TrEMBL:O53621"
/protein_id="CCP42799.1"
/translation="MPAVTTPSNHWGDERRKLSHQPPVRGQILGRRQARRLSQHFARV
GVEAPPKRLQEMLLGAPAADEEWTDVKFALIVTQLNHEKRVAKFHRLQRRATHSLICL
GLVLVALNFLICLAYIFFSLTQHAAAL"
gene complement(85636..86466)
/locus_tag="Rv0077c"
CDS complement(85636..86466)
/codon_start=1
/transl_table=11
/locus_tag="Rv0077c"
/product="Probable oxidoreductase"
/note="Rv0077c, (MTV030.21c), len: 276 aa. Possible
oxidoreductase, weakly similar to others from
Streptomyces. Also similar to MTCY05A6_35 and MTCY1A11_10
from Mycobacterium tuberculosis. And shows some similarity
in part with AAL17935.1|AY054120 putative epoxide
hydrolase from Mycobacterium smegmatis (203 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0077c"
/db_xref="EnsemblGenomes-Tr:CCP42800"
/db_xref="GOA:O53622"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53622"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42800.1"
/translation="MSTIDISAGTIHYEATGPETGRPVVFVHGYMMGGQLWRRVSERL
AGRGLRCIAPTWPLGAHPKPLRPGADQTIGGVAGIVADVLAALELKDVVLVGNDTGGV
VTQLVAVHYPERLGALVLTSCDAFEHFPPPILKPVILAAKSATLFRAAIQVMRAPAAR
NRAYAGLSHHNIDHLTRAWVRPALSNPAIAEDLRQLSLSLRTEVTTAVAARLPEFDKP
ALIAWSADDVFFALENGQRLAATIPRARFEVIEGARTFSMVDSPDRLADQLSTVAVRT
"
gene 86528..87133
/locus_tag="Rv0078"
CDS 86528..87133
/codon_start=1
/transl_table=11
/locus_tag="Rv0078"
/product="Probable transcriptional regulatory protein"
/note="Rv0078, (MTV030.22), len: 201 aa. Probable
transcriptional regulator. Contains probable
helix-turn-helix motif from aa 35 to 56 (Score 1348, +3.78
SD)."
/db_xref="EnsemblGenomes-Gn:Rv0078"
/db_xref="EnsemblGenomes-Tr:CCP42801"
/db_xref="GOA:O53623"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="PDB:5ICJ"
/db_xref="PDB:5N1C"
/db_xref="PDB:5N1I"
/db_xref="PDB:5N7O"
/db_xref="PDB:5WM9"
/db_xref="PDB:6C31"
/db_xref="PDB:6HRW"
/db_xref="PDB:6HRX"
/db_xref="PDB:6HRY"
/db_xref="PDB:6HRZ"
/db_xref="PDB:6HS0"
/db_xref="PDB:6HS1"
/db_xref="PDB:6HS2"
/db_xref="UniProtKB/TrEMBL:O53623"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42801.1"
/translation="MEIKRRTQEERSAATREALITGARKLWGLRGYAEVGTPEIATEA
GVTRGAMYHQFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLE
VSGDPEVRQLILLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPVRPLA
QVLIGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG"
gene complement(87208..87801)
/locus_tag="Rv0078A"
CDS complement(87208..87801)
/codon_start=1
/transl_table=11
/locus_tag="Rv0078A"
/product="Hypothetical protein"
/note="Rv0078A, len: 197 aa. Hypothetical unknown protein.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0078A"
/db_xref="EnsemblGenomes-Tr:CCP42802"
/db_xref="InterPro:IPR014942"
/db_xref="UniProtKB/TrEMBL:L7N686"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42802.1"
/translation="MNAVESTLRRVAKDLTGLRQRWALVGGFAVSARSEPRFTRDVDI
VVAVANDDAAESLVRQLLTQQYHLLASVEQDAARRLAAVRLGATADTAANVVVDLLFA
SCGIEPEIAEAAEEIEILPDLVAPVATTAHLIAMKLLARDDDRRPQDRSDLRALVDAA
SPQDIQDARKAIELITLRGFHRDRDLAAEWTRLAAKW"
gene complement(87798..88004)
/locus_tag="Rv0078B"
CDS complement(87798..88004)
/codon_start=1
/transl_table=11
/locus_tag="Rv0078B"
/product="Conserved protein"
/note="Rv0078B, len: 68 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv0078B"
/db_xref="EnsemblGenomes-Tr:CCP42803"
/db_xref="UniProtKB/TrEMBL:I6X8G2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42803.1"
/translation="MAVSVAAQKLRLALDMYEVGEQMQRMRLGRERPNADVVEIEAAI
DAWRMTRPGAEEGDSAGPTSTRFT"
gene 88204..89025
/locus_tag="Rv0079"
CDS 88204..89025
/codon_start=1
/transl_table=11
/locus_tag="Rv0079"
/product="Unknown protein"
/note="Rv0079, (MTV030.23), len: 273 aa. Unknown protein.
Predicted possible vaccine candidate (See Zvi et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0079"
/db_xref="EnsemblGenomes-Tr:CCP42804"
/db_xref="GOA:P9WMA9"
/db_xref="InterPro:IPR032528"
/db_xref="InterPro:IPR038416"
/db_xref="UniProtKB/Swiss-Prot:P9WMA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42804.1"
/translation="MEPKRSRLVVCAPEPSHAREFPDVAVFSGGRANASQAERLARAV
GRVLADRGVTGGARVRLTMANCADGPTLVQINLQVGDTPLRAQAATAGIDDLRPALIR
LDRQIVRASAQWCPRPWPDRPRRRLTTPAEALVTRRKPVVLRRATPLQAIAAMDAMDY
DVHLFTDAETGEDAVVYRAGPSGLRLARQHHVFPPGWSRCRAPAGPPVPLIVNSRPTP
VLTEAAAVDRAREHGLPFLFFTDQATGRGQLLYSRYDGNLGLITPTGDGVADGLA"
gene 89022..89480
/locus_tag="Rv0080"
CDS 89022..89480
/codon_start=1
/transl_table=11
/locus_tag="Rv0080"
/product="Conserved hypothetical protein"
/note="Rv0080, (MTV030.24), len: 152 aa. Conserved
hypothetical protein. Belongs to pyridoxine 5'-phosphate
(PNP) oxidase-like (PNPOx-like) superfamily."
/db_xref="EnsemblGenomes-Gn:Rv0080"
/db_xref="EnsemblGenomes-Tr:CCP42805"
/db_xref="GOA:P9WMA5"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR024747"
/db_xref="UniProtKB/Swiss-Prot:P9WMA5"
/protein_id="CCP42805.1"
/translation="MSPGSRRASPQSAREVVELDRDEAMRLLASVDHGRVVFTRAALP
AIRPVNHLVVDGRVIGRTRLTAKVSVAVRSSADAGVVVAYEADDLDPRRRTGWSVVVT
GLATEVSDPEQVARYQRLLHPWVNMAMDTVVAIEPEIVTGIRIVADSRTP"
gene 89575..89919
/locus_tag="Rv0081"
CDS 89575..89919
/codon_start=1
/transl_table=11
/locus_tag="Rv0081"
/product="Probable transcriptional regulatory protein"
/note="Rv0081, (MTV030.25), len: 114 aa. Probable
transcriptional regulator, highly similar to others."
/db_xref="EnsemblGenomes-Gn:Rv0081"
/db_xref="EnsemblGenomes-Tr:CCP42806"
/db_xref="GOA:P9WMI7"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:6JMI"
/db_xref="UniProtKB/Swiss-Prot:P9WMI7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42806.1"
/translation="MESEPLYKLKAEFFKTLAHPARIRILELLVERDRSVGELLSSDV
GLESSNLSQQLGVLRRAGVVAARRDGNAMIYSIAAPDIAELLAVARKVLARVLSDRVA
VLEDLRAGGSAT"
gene 89924..90403
/locus_tag="Rv0082"
CDS 89924..90403
/codon_start=1
/transl_table=11
/locus_tag="Rv0082"
/product="Probable oxidoreductase"
/note="Rv0082, (MTV030.26), len: 159 aa. Probable
oxidoreductase, highly similar or similar to other various
oxidoreductases. Nucleotide position 90144 in the genome
sequence has been corrected, A:G resulting in Q74R."
/db_xref="EnsemblGenomes-Gn:Rv0082"
/db_xref="EnsemblGenomes-Tr:CCP42807"
/db_xref="GOA:I6XUD2"
/db_xref="InterPro:IPR006137"
/db_xref="UniProtKB/TrEMBL:I6XUD2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42807.1"
/translation="MGWVAKIFRVGRVVEPAAPLPAAIAEPPAGVRGSLQIRHVDAGS
CNGCEVEISGAFGPVYDAERFGARLVASPRHADALLVTGVVTHNMAGPLRKTLEATPR
PRVVIACGDCALNRGVFADAYGVVGAVGEVVPVDVEIAGCPPTPAAIMAALRSVTGK"
gene 90400..92322
/locus_tag="Rv0083"
CDS 90400..92322
/codon_start=1
/transl_table=11
/locus_tag="Rv0083"
/product="Probable oxidoreductase"
/note="Rv0083, (MTV030.27, MTCY251.01), len: 640 aa.
Probable oxidoreductase, showing some similarity to other
various oxidoreductases. Nucleotide position 91071 in the
genome sequence has been corrected, T:C resulting in
I224I."
/db_xref="EnsemblGenomes-Gn:Rv0083"
/db_xref="EnsemblGenomes-Tr:CCP42808"
/db_xref="GOA:P9WIW3"
/db_xref="InterPro:IPR001750"
/db_xref="InterPro:IPR003918"
/db_xref="UniProtKB/Swiss-Prot:P9WIW3"
/protein_id="CCP42808.1"
/translation="MTAAPTAGGVVTSGVGVAGVGVGLLGMFGPVRVVHVGWLLPLSG
VHIELDRLGGFFMALTGAVAAPVGCYLIGYVRREHLGRVPMAVVPLFVAAMLLVPAAG
SVTTFLLAWELMAIASLILVLSEHARPQVRSAGLWYAVMTQLGFIAILVGLVVLAAAG
GSDRFAGLGAVCDGVRAAVFMLTLVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMSAA
MVNLGIYGIVRFDLQLLGPGPRWWGLALLAVGGTSALYGVLQASVAADLKRLLAYSTT
ENMGLITLALGAATLFADTGAYGPASIAAAAAMLHMIAHAAFKSLAFMAAGSVLAATG
LRDLDLLGGLARRMPATTVFFGVAALGACGLPLGAGFVSEWLLVQSLIHAAPGHDPIV
ALTTPLAVGVVALATGLSVAAMTKAFGIGFLARPRSTQAEAAREAPASMRAGMAIAAG
ACLVLAVAPLLVAPMVRRAAATLPAAQAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLA
AALAVAVLARWRFRRRPAPARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVLRPD
TDIEVTHTAESRYMAERITYRTAVADAIEQRLYTPVVGAVAAMAELLRRAHTGSVHRY
LAYGALGVLIVLVVAR"
gene 92328..93278
/gene="hycD"
/gene_synonym="hevD"
/locus_tag="Rv0084"
CDS 92328..93278
/codon_start=1
/transl_table=11
/gene="hycD"
/gene_synonym="hevD"
/locus_tag="Rv0084"
/product="Possible formate hydrogenlyase HycD (FHL)"
/note="Rv0084, (MTCY251.02), len: 316 aa. Possible hycD
(alternate gene name: hevD), formate
hydrogenlyase,integral membrane protein, similar to
others. Belongs to the complex I subunit 1 family."
/db_xref="EnsemblGenomes-Gn:Rv0084"
/db_xref="EnsemblGenomes-Tr:CCP42809"
/db_xref="GOA:Q10881"
/db_xref="InterPro:IPR001694"
/db_xref="UniProtKB/TrEMBL:Q10881"
/protein_id="CCP42809.1"
/translation="MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRAGAGLLQPWR
DLLKQLGKQQITPAGTTIVFAAAPVIVAGTTLLIAAIAPLVATGSPLDPSADLFAVVG
LLFLGTVALTLAGIDTGTSFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGAL
VASTIDHPGHVVSLAGVLAFVALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAG
PRLALVEWAAGMRLTVLLALLANLFLPWGIAGAAPTALDVLTGVVAVAAKVAILAVLL
ATFEVFLAKLRLFRVPELLAGSFLLALLAVTAANFFTVGA"
gene 93289..93951
/gene="hycP"
/locus_tag="Rv0085"
CDS 93289..93951
/codon_start=1
/transl_table=11
/gene="hycP"
/locus_tag="Rv0085"
/product="Possible hydrogenase HycP"
/note="Rv0085, (MTCY251.03), len: 220 aa. Possible
hycP,hydrogenase, integral membrane protein. Belongs to
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
superfamily."
/db_xref="EnsemblGenomes-Gn:Rv0085"
/db_xref="EnsemblGenomes-Tr:CCP42810"
/db_xref="GOA:P9WM75"
/db_xref="InterPro:IPR038730"
/db_xref="UniProtKB/Swiss-Prot:P9WM75"
/protein_id="CCP42810.1"
/translation="MSNANFSILVDFAAGGLVLASVLIVWRRDLRAIVRLLAWQGAAL
AAIPLLRGIRDNDRALIAVGIAVLALRALVLPWLLARAVGAEAAAQREATPLVNTASS
LLITAGLTLTAFAITQPVVNLEPGVTINAVPAAFAVVLIALFVMTTRLHAVSQAAGFL
MLDNGIAATAFLLTAGVPLIVELGASLDVLFAVIVIGVLTGRLRRIFGDADLDKLREL
RD"
gene 93951..95417
/gene="hycQ"
/locus_tag="Rv0086"
CDS 93951..95417
/codon_start=1
/transl_table=11
/gene="hycQ"
/locus_tag="Rv0086"
/product="Possible hydrogenase HycQ"
/note="Rv0086, (MTCY251.04), len: 488 aa. Possible
hycQ,hydrogenase, integral membrane protein. Belongs to
the NADH-Ubiquinone/plastoquinone (complex I)
superfamily."
/db_xref="EnsemblGenomes-Gn:Rv0086"
/db_xref="EnsemblGenomes-Tr:CCP42811"
/db_xref="GOA:Q10883"
/db_xref="InterPro:IPR001750"
/db_xref="UniProtKB/TrEMBL:Q10883"
/protein_id="CCP42811.1"
/translation="MTGLLLAAILAPLAASIASLITGWRRTTATLTALSATTVLACAV
AMGFWMGSGAQFGLGGLLRADALTVVMLVVIGIVGTLATAASIGYIDTELAHGHIDGR
SARLYGVLTPAFLCAMVLAVCANNIGVIWVAIEATTVITAFLVGHRRTRTALEATWKY
VVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLL
IGYGAKAGLFPFHTWLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAY
LRNGLLVVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLL
HVLAHGIGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVGLIVLLGLPPF
AMFASELAIARSLANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPAITVP
ATAAAALMVGIVVSAALGITAGPLADLLGIAASNVGLP"
gene 95414..96892
/gene="hycE"
/gene_synonym="hevE"
/locus_tag="Rv0087"
CDS 95414..96892
/codon_start=1
/transl_table=11
/gene="hycE"
/gene_synonym="hevE"
/locus_tag="Rv0087"
/product="Possible formate hydrogenase HycE (FHL)"
/note="Rv0087, (MTCY251.05), len: 492 aa. Possible hycE
(alternate gene name: hevE), formate hydrogenlyase,
similar to others. Belongs to the complex I 49 kDa subunit
family."
/db_xref="EnsemblGenomes-Gn:Rv0087"
/db_xref="EnsemblGenomes-Tr:CCP42812"
/db_xref="GOA:Q10884"
/db_xref="InterPro:IPR001135"
/db_xref="InterPro:IPR001268"
/db_xref="InterPro:IPR001501"
/db_xref="InterPro:IPR020396"
/db_xref="InterPro:IPR029014"
/db_xref="InterPro:IPR037232"
/db_xref="InterPro:IPR038290"
/db_xref="UniProtKB/TrEMBL:Q10884"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42812.1"
/translation="MMSASWLRHRVSERGLIATAEQLWADSFRLALVAAHDDGDSLRV
VYLFLAGYPDRRVELEYVVPADNPEIRSLAYLSFPAGRFEREMADLYGIRPVGHPKPR
RLVRHAHWPDWHPMRTDAGPAPEFTDTGAFPFLAVEGPGVYEIPVGPVHAGLIEPGHF
RFSVAGETIVRLKARLWFVHRGIEKLFHGRPATAAVDLAERISGDTSAAHALAHSLAI
EDALGIELPHEVHRLRALIVELERLYNHAADLGALANDVGYSLANAHAQRIRENLLRR
NAAVTGHRLLRGAIRAGGVALRALPDTDELAALAVDLAEVATLTLANSVVYDRFAGTA
VLHPDDASALGCLGYVARASGLRSDARVEHPTIVLPITEIGAPDGDVLARYTVRRDEF
AASAALAQHIVESHTGPIEYAATLHPVGAPSSGIGIVEGWRGTIVHRVEIDVDGRITR
AKVVDPSWFNWPALPVAMADTIVPDFPLANKSFNQSYAGNDL"
gene 96927..97601
/locus_tag="Rv0088"
CDS 96927..97601
/codon_start=1
/transl_table=11
/locus_tag="Rv0088"
/product="Possible polyketide cyclase/dehydrase"
/note="Rv0088, (MTCY251.06), len: 224 aa. Possible
polyketide cyclase/dehydrase. Belongs to the SRPBCC
ligand-binding domain superfamily. Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0088"
/db_xref="EnsemblGenomes-Tr:CCP42813"
/db_xref="GOA:P9WM73"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/Swiss-Prot:P9WM73"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42813.1"
/translation="MSVYKHAPSRVRLRQTRSTVVKGRSGSLSWRRVRTGDLGLAVWG
GREEYRAVKPGTPGIQPKGDMMTVTVVDAGPGRVSRSVEVAAPAAELFAIVADPRRHR
ELDGSGTVRGNIKVPAKLVVGSKFSTKMKLFGLPYRITSRVTALKPNELVEWSHPLGH
RWRWEFESLSPTLTRVTETFDYHAAGAIKNGLKFYEMTGFAKSNAAGIEATLAKLSDQ
YARGRA"
gene 97758..98351
/locus_tag="Rv0089"
CDS 97758..98351
/codon_start=1
/transl_table=11
/locus_tag="Rv0089"
/product="Possible methyltransferase/methylase"
/note="Rv0089, (MTCY251.07), len: 197 aa. Possible
methyltransferase, showing some weak similarity to others.
Also some similarity with many biotin biosynthesis
proteins. Belongs to the methyltransferase superfamily."
/db_xref="EnsemblGenomes-Gn:Rv0089"
/db_xref="EnsemblGenomes-Tr:CCP42814"
/db_xref="GOA:P9WK03"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WK03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42814.1"
/translation="MDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRI
PYVTAVDIDAPVLRRAQTRFANAPIRWLHADIMTAELPNAGFDAVVSNAALHHIEDTR
TALSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVACGMANRVKGKWEHSAPIKWP
PPQTLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV"
gene 98480..99250
/locus_tag="Rv0090"
CDS 98480..99250
/codon_start=1
/transl_table=11
/locus_tag="Rv0090"
/product="Possible membrane protein"
/note="Rv0090, (MTCY251.08), len: 256 aa. Possible
membrane protein. Contains IPR014511 Protein of unknown
function DUF2068, transmembrane, subgroup."
/db_xref="EnsemblGenomes-Gn:Rv0090"
/db_xref="EnsemblGenomes-Tr:CCP42815"
/db_xref="GOA:P9WM71"
/db_xref="InterPro:IPR014511"
/db_xref="InterPro:IPR021125"
/db_xref="UniProtKB/Swiss-Prot:P9WM71"
/protein_id="CCP42815.1"
/translation="MAKNQNRIRNRWELITCGLGGHVTYAPDDAALAARLRASTGLGE
VWRCLRCGDFALGGPQGRGAPEDAPLIMRGKALRQAIIIRALGVERLVRALVLALAAW
AVWEFRGARGAIQATLDRDLPVLRAAGFKVDQMTVIHALEKALAAKPSTLALITGMLA
AYAVLQAVEGVGLWLLKRWGEYFAVVATSIFLPLEVHDLAKGITTTRVVTFSINVAAV
VYLLISKRLFGVRGGRKAYDVERRGEQLLDLERAAMLT"
gene 99684..100451
/gene="mtn"
/gene_synonym="pfs"
/locus_tag="Rv0091"
CDS 99684..100451
/codon_start=1
/transl_table=11
/gene="mtn"
/gene_synonym="pfs"
/locus_tag="Rv0091"
/product="Probable bifunctional MTA/SAH nucleosidase Mtn:
5'-methylthioadenosine nucleosidase (methylthioadenosine
methylthioribohydrolase) + S-adenosylhomocysteine
nucleosidase (S-adenosyl-L-homocysteine
homocysteinylribohydrolase)"
/note="Rv0091, (MTCY251.10), len: 255 aa. Probable mtn
(alternate gene name:
pfs),methylthioadenosine/S-Adenosylhomocysteine
nucleosidase (MTA/SAH nucleosidase), including
5'-methylthioadenosine nucleosidase and
S-adenosylhomocysteine nucleosidase,similar to others.
Belongs to the MTN family."
/db_xref="EnsemblGenomes-Gn:Rv0091"
/db_xref="EnsemblGenomes-Tr:CCP42816"
/db_xref="GOA:P9WJM3"
/db_xref="InterPro:IPR000845"
/db_xref="InterPro:IPR035994"
/db_xref="UniProtKB/Swiss-Prot:P9WJM3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42816.1"
/translation="MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHR
VVLAAAGMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDF
GLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGR
QPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRAL
SDLAGADSGVDFNRFVGEVAASSARVLLRLLPVLTAC"
gene 100583..102868
/gene="ctpA"
/locus_tag="Rv0092"
CDS 100583..102868
/codon_start=1
/transl_table=11
/gene="ctpA"
/locus_tag="Rv0092"
/product="Cation transporter P-type ATPase a CtpA"
/note="Rv0092, (MTCY251.11), len: 761 aa.
CtpA,cation-transporting P-type ATPase a (transmembrane
protein), highly similar to many. Contains PS01047
Heavy-metal-associated domain, and PS00154 E1-E2 ATPases
phosphorylation site. Belongs to the cation transport
ATPases family (E1-E2 ATPases), subfamily IB."
/db_xref="EnsemblGenomes-Gn:Rv0092"
/db_xref="EnsemblGenomes-Tr:CCP42817"
/db_xref="GOA:P9WPU1"
/db_xref="InterPro:IPR000579"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR006121"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR017969"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR027256"
/db_xref="InterPro:IPR036163"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPU1"
/inference="protein motif:PROSITE:PS01047"
/inference="protein motif:PROSITE:PS00154"
/protein_id="CCP42817.1"
/translation="MTTAVTGEHHASVQRIQLRISGMSCSACAHRVESTLNKLPGVRA
AVNFGTRVATIDTSEAVDAAALCQAVRRAGYQADLCTDDGRSASDPDADHARQLLIRL
AIAAVLFVPVADLSVMFGVVPATRFTGWQWVLSALALPVVTWAAWPFHRVAMRNARHH
AASMETLISVGITAATIWSLYTVFGNHSPIERSGIWQALLGSDAIYFEVAAGVTVFVL
VGRYFEARAKSQAGSALRALAALSAKEVAVLLPDGSEMVIPADELKEQQRFVVRPGQI
VAADGLAVDGSAAVDMSAMTGEAKPTRVRPGGQVIGGTTVLDGRLIVEAAAVGADTQF
AGMVRLVEQAQAQKADAQRLADRISSVFVPAVLVIAALTAAGWLIAGGQPDRAVSAAL
AVLVIACPCALGLATPTAMMVASGRGAQLGIFLKGYKSLEATRAVDTVVFDKTGTLTT
GRLQVSAVTAAPGWEADQVLALAATVEAASEHSVALAIAAATTRRDAVTDFRAIPGRG
VSGTVSGRAVRVGKPSWIGSSSCHPNMRAARRHAESLGETAVFVEVDGEPCGVIAVAD
AVKDSARDAVAALADRGLRTMLLTGDNPESAAAVATRVGIDEVIADILPEGKVDVIEQ
LRDRGHVVAMVGDGINDGPALARADLGMAIGRGTDVAIGAADIILVRDHLDVVPLALD
LARATMRTVKLNMVWAFGYNIAAIPVAAAGLLNPLVAGAAMAFSSFFVVSNSLRLRKF
GRYPLGCGTVGGPQMTAPSSA"
gene complement(102815..103663)
/locus_tag="Rv0093c"
CDS complement(102815..103663)
/codon_start=1
/transl_table=11
/locus_tag="Rv0093c"
/product="Probable conserved membrane protein"
/note="Rv0093c, (MTCY251.12c), len: 282 aa. Probable
conserved membrane protein, equivalent only to
CAC30943.1|AL583924 probable integral membrane protein
from Mycobacterium leprae (237 aa). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0093c"
/db_xref="EnsemblGenomes-Tr:CCP42818"
/db_xref="GOA:P9WM69"
/db_xref="InterPro:IPR027383"
/db_xref="UniProtKB/Swiss-Prot:P9WM69"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42818.1"
/translation="MLAQATTAGSFNHHASTVLQGCRGVPAAMWSEPAGAIRRHCATI
DGMDCEVAREALSARLDGERAPVPSARVDEHLGECSACRAWFTQVASQAGDLRRLAES
RPVVPPVGRLGIRRAPRRQHSPMTWRRWALLCVGIAQIALGTVQGFGLDVGLTHQHPT
GAGTHLLNESTSWSIALGVIMVGAALWPSAAAGLAGVLTAFVAILTGYVIVDALSGAV
STTRILTHLPVVIGAVLAIMVWRSASGPRPRPDAVAAEPDIVLPDNASRGRRRGHLWP
TDGSAA"
gene complement(103710..104663)
/locus_tag="Rv0094c"
CDS complement(103710..104663)
/codon_start=1
/transl_table=11
/locus_tag="Rv0094c"
/product="Conserved hypothetical protein"
/note="Rv0094c, (MTCY251.13c), len: 317 aa. Member of
13E12 repeat family, showing some similarity to
U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA
score: (49.4% identity in 79 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0094c"
/db_xref="EnsemblGenomes-Tr:CCP42819"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:Q50655"
/protein_id="CCP42819.1"
/translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTE
RARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTP
DAAAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGK
GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIM
LFANDRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHN
NTHGHTEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD"
repeat_region complement(103713..105215)
/note="REP-2, len: 1503 nt. REP251, member of REP13E12
family."
gene complement(104805..105215)
/locus_tag="Rv0095c"
CDS complement(104805..105215)
/codon_start=1
/transl_table=11
/locus_tag="Rv0095c"
/product="Conserved hypothetical protein"
/note="Rv0095c, (MTCY251.14c), len: 136 aa. Member of
13E12 repeat, also partially similar to AF0418|AF041819_8
from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6%
identity in 96 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0095c"
/db_xref="EnsemblGenomes-Tr:CCP42820"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:Q10891"
/protein_id="CCP42820.1"
/translation="MRYLPVSTRRIWVNPLCHFSFTVISGALFVSARRYDSNMLANSR
EELVEVFDALDADLDRLDEVSFEVLSTPERLRSLERLECLARRLPAAQHTLINQLDTQ
ASEEELGGTLCCALANRLRITKPEAGRRSAEAKP"
gene 105324..106715
/gene="PPE1"
/locus_tag="Rv0096"
CDS 105324..106715
/codon_start=1
/transl_table=11
/gene="PPE1"
/locus_tag="Rv0096"
/product="PPE family protein PPE1"
/note="Rv0096, (MTCY251.15), len: 463 aa. PPE1, Member of
the Mycobacterium tuberculosis PPE family, similar to
many. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0096"
/db_xref="EnsemblGenomes-Tr:CCP42821"
/db_xref="GOA:P9WI49"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42821.1"
/translation="MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQ
LLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSAVTAAQHVAAAAAYCSALAAMP
TPAELAANHAIHGVLIATNFFGINTVPIALNEADYVRMWLQAADTMAAYQAVADAATV
AVPSTQPAPPIRAPGGDAADTRLDVLSSIGQLIRDILDFIANPYKYFLEFFEQFGFSP
AVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLL
PIAAALGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISY
AVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRD
EFLDATATVDAATDVPAPANAAGSQGAGTLGFAGTAPTTSGAAAGMVQLSSHSTSTTV
PLLPTTWTTDAEQ"
gene 106734..107603
/locus_tag="Rv0097"
CDS 106734..107603
/codon_start=1
/transl_table=11
/locus_tag="Rv0097"
/product="Possible oxidoreductase"
/note="Rv0097, (MTCY251.16), len: 289 aa. Possible
oxidoreductase, equivalent to NP_302343.1|NC_002677
putative oxidoreductase from Mycobacterium leprae (289
aa). Also highly similar to BAB69377.1|AB070955 putative
oxidoreductase from Streptomyces avermitilis (296 aa).
Contains PS00077 Cytochrome c oxidase subunit I, copper B
binding region signature."
/db_xref="EnsemblGenomes-Gn:Rv0097"
/db_xref="EnsemblGenomes-Tr:CCP42822"
/db_xref="GOA:P9WG83"
/db_xref="InterPro:IPR003819"
/db_xref="InterPro:IPR042098"
/db_xref="UniProtKB/Swiss-Prot:P9WG83"
/inference="protein motif:PROSITE:PS00077"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42822.1"
/translation="MTLKVKGEGLGAQVTGVDPKNLDDITTDEIRDIVYTNKLVVLKD
VHPSPREFIKLGRIIGQIVPYYEPMYHHEDHPEIFVSSTEEGQGVPKTGAFWHIDYMF
MPEPFAFSMVLPLAVPGHDRGTYFIDLARVWQSLPAAKRDPARGTVSTHDPRRHIKIR
PSDVYRPIGEVWDEINRTTPPIKWPTVIRHPKTGQEILYICATGTTKIEDKDGNPVDP
EVLQELMAATGQLDPEYQSPFIHTQHYQVGDIILWDNRVLMHRAKHGSAAGTLTTYRL
TMLDGLKTPGYAA"
gene 107600..108151
/gene="fcoT"
/locus_tag="Rv0098"
CDS 107600..108151
/codon_start=1
/transl_table=11
/gene="fcoT"
/locus_tag="Rv0098"
/product="Probable fatty acyl CoA thioesterase type III
FcoT"
/note="Rv0098, (MTCY251.17), len: 183 aa. FcoT, long-chain
fatty acyl CoA thioesterase type III (See Wang et
al.,2007), equivalent to CAC30948.1|AL583924 from
Mycobacterium leprae (183 aa). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004)."
/db_xref="EnsemblGenomes-Gn:Rv0098"
/db_xref="EnsemblGenomes-Tr:CCP42823"
/db_xref="GOA:P9WM67"
/db_xref="InterPro:IPR022598"
/db_xref="PDB:2PFC"
/db_xref="PDB:3B18"
/db_xref="UniProtKB/Swiss-Prot:P9WM67"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42823.1"
/translation="MSHTDLTPCTRVLASSGTVPIAEELLARVLEPYSCKGCRYLIDA
QYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVL
RGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCV
IEFWDENGGAASGEIELAALNIP"
gene 108156..109778
/gene="fadD10"
/locus_tag="Rv0099"
CDS 108156..109778
/codon_start=1
/transl_table=11
/gene="fadD10"
/locus_tag="Rv0099"
/product="Possible fatty-acid-CoA ligase FadD10
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0099, (MTCY251.18), len: 540 aa. Possible
fadD10,fatty-acid-CoA synthetase, similar to many.
Contains PS00455 putative AMP-binding domain signature.
Contains IPR000873 AMP-dependent synthetase/ligase domain.
Belongs to the ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv0099"
/db_xref="EnsemblGenomes-Tr:CCP42824"
/db_xref="GOA:P9WQ55"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ55"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42824.1"
/translation="MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRY
RELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLPI
AAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAVTRESEHSLDAASL
AGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTY
SPLPATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVS
ELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDG
SIVKIEAGAVGRPYPGVDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNP
ERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGV
REAACYEIPDEEFGALVGLAVVASAELDESAARALKHTIAARFRRESEPMARPSTIVI
VTDIPRTQSGKVMRASLAAAATADKARVVVRG"
gene 109783..110019
/locus_tag="Rv0100"
CDS 109783..110019
/codon_start=1
/transl_table=11
/locus_tag="Rv0100"
/product="Conserved hypothetical protein"
/note="Rv0100, (MTCY251.19), len: 78 aa. Conserved
hypothetical protein, equivalent only to
CAC30950.1|AL583924 conserved hypothetical protein from
Mycobacterium leprae (78 aa). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0100"
/db_xref="EnsemblGenomes-Tr:CCP42825"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/Swiss-Prot:P9WM65"
/protein_id="CCP42825.1"
/translation="MRDRILAAVCDVLYIDEADLIDGDETDLRDLGLDSVRFVLLMKQ
LGVNRQSELPSRLAANPSIAGWLRELEAVCTEFG"
gene 110001..117539
/gene="nrp"
/locus_tag="Rv0101"
CDS 110001..117539
/codon_start=1
/transl_table=11
/gene="nrp"
/locus_tag="Rv0101"
/product="Probable peptide synthetase Nrp (peptide
synthase)"
/note="Rv0101, (MTCY251.20), len: 2512 aa. Probable
nrp,peptide synthetase, similar to others e.g.
AAD44234.1|AF143772_40|PstB peptide synthetase from
Mycobacterium avium (2552 aa); 7476034|S77657 cyclic
peptide synthetase from Mycobacterium leprae (1401
aa),FASTA scores: opt: 4268, E(): 0, (65.7% identity in
1091 aa overlap); part of CAB55600.1|AJ238027 peptide
synthetase from Mycobacterium smegmatis (5990). Also
similar to e.g. AAD56240.1|AF184977_1|AF184977 DhbF
protein from Bacillus subtilis (2378 aa);
SRF1_BACSU|P27206 surfactin synthetase subunit 1 (3587
aa), FASTA scores: opt: 1708, E(): 0,(30.6% identity in
1633 aa overlap): etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop), 2 x PS00455 Putative AMP-binding
domain signature, and PS00012 Phosphopantetheine
attachment site. Belongs to the ATP-dependent AMP-binding
enzyme family. Thought to be not involved in mycobactin
biosynthesis (see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv0101"
/db_xref="EnsemblGenomes-Tr:CCP42826"
/db_xref="GOA:Q10896"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR010071"
/db_xref="InterPro:IPR010080"
/db_xref="InterPro:IPR013120"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="PDB:4DQV"
/db_xref="PDB:4U5Q"
/db_xref="UniProtKB/TrEMBL:Q10896"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00455"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42826.1"
/translation="MHRVRLSRSQRNLYNGVRQDNNPALYLIGKSYRFRRLELARFLA
ALHATVLDNPVQLCVLENSGADYPDLVPRLRFGDIVRVGSADEHLQSTWCSGILGKPL
VRHTVHTDPNGYVTGLDVHTHHILLDGGATGTIEADLARYLTTDPAGETPSVGAGLAK
LREAHRRETAKVEESRGRLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATI
CGNAFDAILTLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVA
TCLVNSVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWLREEHYRRMYLAINRTSHVE
ALTLNFIREPCAPGLRPFLSEVPIATDIGPVEGMTVASVLDEEQRTLNLAIWNRADLP
ACKTHPKVAERIAAALESMAAMWDRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAW
FLDSARGVHQFLGRRRFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGC
GYSVCDTADEISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDERVTQVTH
DALLATKTAYIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAHDTVLQCAPLTS
DISVEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARETTIVDLPTAVWQLLCADGD
AIDAIGRSRLRQIVIGGEAIRCSAVDKWLESAASQGISLLSSYGPTEATVVATFLPIV
CDQTTMDGALLRLGRPILPNTVFLAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSR
RRAFATGDRVTVDAEGFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELH
SGSLGVWFKSQRTREGEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSDN
LPRLPQWSAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGSLDLIRILPE
TRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRPLVAAQRPAAIPLSFAQR
RLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVDGVPR
QLVIEARRADLGCDIVDATAWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEH
VLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQREILGD
LDDSDSPIAAQLAYWENALAGMPERLRLPTARPYPPVADQRGASLVVDWPASVQQQVR
RIARQHNATSFMVVAAGLAVLLSKLSGSPDVAVGFPIAGRSDPALDNLVGFFVNTLVL
RVNLAGDPSFAELLGQVRARSLAAYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQ
DNPVGQLNLGDLQATPMPIDTRTARMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEA
QAIDVLIERLRKVLVAVAAAPERTVSSIDALDGTERARLDEWGNRAVLTAPAPTPVSI
PQMLAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERC
APAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLAGHDLPI
IDVVDALAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHRNVTRLFASLPARLS
AAQVWSQCHSYGFDASAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEHVSVLTQ
TPAAVAMLPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTICAAISAPL
RPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGVGVGYWRRAGLTASRF
VACPFGGSGARMYRTGDLVCWRADGQLEFLGRTDDQVKIRGYRIELGEVATALAELAG
VGQAVVIAREDRPGDKRLVGYATEIAPGAVDPAGLRAQLAQRLPGYLVPAAVVVIDAL
PLTVNGKLDHRALPAPEYGDTNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELG
GDSLAAMRVIAAINTTLNADLPVRALLHASSTRGLSQLLGRDARPTSDPRLVSVHGDN
PTEVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGRYLVLELLRRLD
VDGRLICLVRAESDEDARRRLEKTFDSGDPELLRHFKELAADRLEVVAGDKSEPDLGL
DQPMWRRLAETVDLIVDSAAMVNAFPYHELFGPNVAGTAELIRIALTTKLKPFTYVST
ADVGAAIEPSAFTEDADIRVISPTRTVDGGWAGGYGTSKWAGEVLLREANDLCALPVA
VFRCGMILADTSYAGQLNMSDWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLP
VTFVAEAIAVLGARVAGSSLAGFATYHVMNPHDDGIGLDEYVDWLIEAGYPIRRIDDF
AEWLQRFEASLGALPDRQRRHSVLPMLLASNSQRLQPLKPTRGCSAPTDRFRAAVRAA
KVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL"
gene 117714..119699
/locus_tag="Rv0102"
CDS 117714..119699
/codon_start=1
/transl_table=11
/locus_tag="Rv0102"
/product="Probable conserved integral membrane protein"
/note="Rv0102, (MTCY251.21), len: 661 aa. Probable
conserved integral membrane protein, highly similar to
P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible
membrane protein from Mycobacterium leprae (659 aa), FASTA
scores: opt: 3107, E(): 0, (70.2% identity in 662 aa
overlap). Also similar to others e.g. CAC01497.1|AL391017
putative integral membrane protein from Streptomyces
coelicolor (316 aa); etc. Contains PS00343 Gram-positive
cocci surface proteins 'anchoring' hexapeptide."
/db_xref="EnsemblGenomes-Gn:Rv0102"
/db_xref="EnsemblGenomes-Tr:CCP42827"
/db_xref="GOA:P9WM63"
/db_xref="InterPro:IPR008457"
/db_xref="InterPro:IPR019108"
/db_xref="UniProtKB/Swiss-Prot:P9WM63"
/inference="protein motif:PROSITE:PS00343"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42827.1"
/translation="MGTHGATKSATSAVPTPRSNSMAMVRLAIGLLGVCAVVAAFGLV
SGARRYAEAGNPYPGAFVSVAEPVGFFAASLAGALCLGALIHVVMTAKPEPDGLIDAA
AFRIHLLAERVSGLWLGLAATMVVIQAAHDTGVGPARLLASGALSDSVAASEMARGWI
VAAICALVVATALRLYTRWLGHVVLLVPTVLAVVATAVTGNPGQGPDHDYATSAAIVF
AVAFATLTGLKIAAALAGTTPSRAVLVTQVTCGALALAYGAMLLYLFIPGWAVDSDFA
RLGLLAGVILTSVWLFDCWRLLVRPPHAGRRRGGGSGAALAMMAAMASIAAMAVMTAP
RFLTHAFTAWDVFLGYELPQPPTIARVLTVWRFDSLIGAAGVVLAIGYAAGFAALRRR
GNSWPVGRLIAWLTGCAALVFTSGSGVRAYGSAMFSVHMAEHMTLNMFIPVLLVLGGP
VTLALRVLPVTGDGRPPGAREWLTWLLHSRVTTFLSHPITAFVLFVASPYIVYFTPLF
DTFVRYHWGHEFMAIHFLVVGYLFYWAIIGIDPGPRRLPYPGRIGLLFAVMPFHAFFG
IALMTMSSTVGATFYRSVNLPWLSSIIADQHLGGGIAWSLTELPVIMVIVALVTQWAR
QDRRVASREDRHADSDYADDELEAYNAMLRELSRMRR"
gene complement(119915..122173)
/gene="ctpB"
/locus_tag="Rv0103c"
CDS complement(119915..122173)
/codon_start=1
/transl_table=11
/gene="ctpB"
/locus_tag="Rv0103c"
/product="Probable cation-transporter P-type ATPase B
CtpB"
/note="Rv0103c, (MTCY251.22c), len: 752 aa. Probable
ctpB,cation-transporting P-type ATPase B (transmembrane
protein), equivalent to CTPB_MYCLE|P46840
cation-transporting P-type ATPase B from Mycobacterium
leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5%
identity in 752 aa overlap). Also highly similar to others
e.g. CAB96031.1|AL360055 putative metal transporter ATPase
from Streptomyces coelicolor (753 aa);
NP_241423.1|NC_002570 copper-transporting ATPase from
Bacillus halodurans (806 aa); etc. Also highly similar to
Z46257|MLACEA_7 aceA gene for isocitrate L from
Mycobacterium leprae (750 aa), FASTA scores: opt:
3615,E():0, (76.5% identity in 752 aa overlap). And
similar to MTCY251.11 from Mycobacterium tuberculosis,
FASTA score: (68.3% identity in 742 aa overlap). Contains
PS01047 Heavy-metal-associated domain, PS00154 E1-E2
ATPases phosphorylation site. Belongs to the cation
transport ATPases family (E1-E2 ATPases), subfamily IB."
/db_xref="EnsemblGenomes-Gn:Rv0103c"
/db_xref="EnsemblGenomes-Tr:CCP42828"
/db_xref="GOA:P9WPT9"
/db_xref="InterPro:IPR000579"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR006121"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR017969"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR027256"
/db_xref="InterPro:IPR036163"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPT9"
/inference="protein motif:PROSITE:PS00154"
/inference="protein motif:PROSITE:PS01047"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42828.1"
/translation="MAAPVVGDADLQSVRRIRLDVLGMSCAACASRVETKLNKIPGVR
ASVNFATRVATIDAVGMAADELCGVVEKAGYHAAPHTETTVLDKRTKDPDGAHARRLL
RRLLVAAVLFVPLADLSTLFAIVPSARVPGWGYILTALAAPVVTWAAWPFHSVALRNA
RHRTTSMETLISVGIVAATAWSLSSVFGDQPPREGSGIWRAILNSDSIYLEVAAGVTV
FVLAGRYFEARAKSKAGSALRALAELGAKNVAVLLPDGAELVIPASELKKRQRFVTRP
GETIAADGVVVDGSAAIDMSAMTGEAKPVRAYPAASVVGGTVVMDGRLVIEATAVGAD
TQFAAMVRLVEQAQTQKARAQRLADHIAGVFVPVVFVIAGLAGAAWLVSGAGADRAFS
VTLGVLVIACPCALGLATPTAMMVASGRGAQLGIFIKGYRALETIRSIDTVVFDKTGT
LTVGQLAVSTVTMAGSGTSERDREEVLGLAAAVESASEHAMAAAIVAASPDPGPVNGF
VAVAGCGVSGEVGGHHVEVGKPSWITRTTPCHDAALVSARLDGESRGETVVFVSVDGV
VRAALTIADTLKDSAAAAVAALRSRGLRTILLTGDNRAAADAVAAQVGIDSAVADMLP
EGKVDVIQRLREEGHTVAMVGDGINDGPALVGADLGLAIGRGTDVALGAADIILVRDD
LNTVPQALDLARATMRTIRMNMIWAFGYNVAAIPIAAAGLLNPLIAGAAMAFSSFFVV
SNSLRLRNFGAQ"
gene 122317..123831
/locus_tag="Rv0104"
CDS 122317..123831
/codon_start=1
/transl_table=11
/locus_tag="Rv0104"
/product="Conserved hypothetical protein"
/note="Rv0104, (MTCY251.23), len: 504 aa. Conserved
hypothetical protein, showing weak similarity with other
cAMP-dependent protein kinases e.g. AAC37564.1|M65066
cAMP-dependent protein kinase RI-beta regulatory subunit
from Homo sapiens (380 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0104"
/db_xref="EnsemblGenomes-Tr:CCP42829"
/db_xref="GOA:P9WM61"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR042172"
/db_xref="UniProtKB/Swiss-Prot:P9WM61"
/protein_id="CCP42829.1"
/translation="MTPVTTFPLVDAILAGRDRNLDGVILIAAQHLLQTTHAMLRSLF
RVGLDPRNVAVIGKCYSTHPGVVDAMRADGIYVDDCSDAYAPHESFDTQYTRHVERFF
AESWARLTAGRTARVVLLDDGGSLLAVAGAMLDASADVIGIEQTSAGYAKIVGCALGF
PVINIARSSAKLLYESPIIAARVTQTAFERTAGIDSSAAILITGAGAIGTALADVLRP
LHDRVDVYDTRSGCMTPIDLPNAIGGYDVIIGATGATSVPASMHELLRPGVLLMSASS
SDREFDAVALRRRTTPNPDCHADLRVADGSVDATLLNSGFPVNFDGSPMCGDASMALT
MALLAAAVLYASVAVADEMSSDHPHLGLIDQGDIVASFLNIDVPLQALSRLPLLSIDG
YRRLQVRSGYTLFRQGERADHFFVIESGELEALVDGKVILRLGAGDHFGEACLLGGMR
RIATVRACEPSVLWELDGKAFGDALHGDAAMREIAYGVARTRLMHAGASESLMV"
gene complement(123980..124264)
/gene="rpmB1"
/locus_tag="Rv0105c"
CDS complement(123980..124264)
/codon_start=1
/transl_table=11
/gene="rpmB1"
/locus_tag="Rv0105c"
/product="50S ribosomal protein L28-1 RpmB1"
/note="Rv0105c, (MTCY251.24c), len: 94 aa. rpmB1, 50S
ribosomal protein L28-1, highly similar to others e.g.
Q9X8K8|R28B_STRCO 50S ribosomal protein L28-2 from
Streptomyces coelicolor (78 aa); RL28_ECOLI|P02428 50s
ribosomal protein l28 from Escherichia coli (77 aa), FASTA
scores: opt: 167, E(): 6.2e-06, (40.7% identity in 59 aa
overlap); etc. Also similar to MTCY63A_2 from
Mycobacterium tuberculosis. Belongs to the L28P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0105c"
/db_xref="EnsemblGenomes-Tr:CCP42830"
/db_xref="GOA:P9WHB1"
/db_xref="InterPro:IPR001383"
/db_xref="InterPro:IPR026569"
/db_xref="InterPro:IPR034704"
/db_xref="InterPro:IPR037147"
/db_xref="UniProtKB/Swiss-Prot:P9WHB1"
/protein_id="CCP42830.1"
/translation="MSARCQITGRTVGFGKAVSHSHRRTRRRWPPNIQLKAYYLPSED
RRIKVRVSAQGIKVIDRDGHRGRRRAARAGSAPAHFARQAGSSLRTAAIL"
gene 124374..125570
/locus_tag="Rv0106"
CDS 124374..125570
/codon_start=1
/transl_table=11
/locus_tag="Rv0106"
/product="Conserved hypothetical protein"
/note="Rv0106, (MTCY251.25), len: 398 aa. Conserved
hypothetical protein, similar to others e.g.
AL049841|SCE9_33 from Streptomyces coelicolor (370
aa),FASTA scores: opt: 282, E(): 2.5e-11, (32.0% identity
in 381 aa overlap); etc. Some similarity to P94400
homologue to nitrile hydratase region from Bacillus
subtilis (397 aa), FASTA scores: opt: 226, E(): 5.4e-08,
(26.4% identity in 405 aa overlap). Also similar to
COBW_PSEDE|P29937 FASTA score: (25.3% identity in 186 aa
overlap); and P47K_PSECL|P31521 47 kDa protein (p47k) (419
aa), FASTA score: (25.9% identity in 401 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0106"
/db_xref="EnsemblGenomes-Tr:CCP42831"
/db_xref="InterPro:IPR003495"
/db_xref="InterPro:IPR011629"
/db_xref="UniProtKB/Swiss-Prot:P9WPI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42831.1"
/translation="MRTPVILVAGQDHTDEVTGALLRRTGTVVVEHRFDGHVVRRMTA
TLSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAPWLEPQPI
CWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSLGEDELPDGRTVAQVT
VGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGGVDRVELALAHLDDNSRRGRTDTP
HTPLLAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLWLANRPD
QVMWLESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVL
VCGADPTDIVNALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHR
NSGESR"
gene complement(125643..130541)
/gene="ctpI"
/locus_tag="Rv0107c"
CDS complement(125643..130541)
/codon_start=1
/transl_table=11
/gene="ctpI"
/locus_tag="Rv0107c"
/product="Probable cation-transporter ATPase I CtpI"
/note="Rv0107c, (MTCY251.26c, MTV031.01c), len: 1632 aa.
Probable ctpI, cation-transporting ATPase I P-type, highly
similar to NP_302704.1|NC_002677 probable cation transport
ATPase from Mycobacterium leprae (1609 aa); and similar to
others e.g. CAB69720.1|AL137166 putative transport ATPase
from Streptomyces coelicolor (1472 aa); ATA1_SYNY|P37367
cation-transporting ATPase pma1 from Synechocystis sp.
(915 aa), FASTA scores: opt: 603, E(): 6.6e-29, (32.4%
identity in 710 aa overlap); etc. Also similar to
MTCY39.21c and MTCY22G10.22c from Mycobacterium
tuberculosis, FASTA score: (34.4% identity in 796 aa
overlap). Contains PS00154 E1-E2 ATPases phosphorylation
site. Belongs to the cation transport ATPases family
(E1-E2 ATPases)."
/db_xref="EnsemblGenomes-Gn:Rv0107c"
/db_xref="EnsemblGenomes-Tr:CCP42832"
/db_xref="GOA:P9WPS5"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR006068"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPS5"
/inference="protein motif:PROSITE:PS00154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42832.1"
/translation="MKIPGVATVLGGVTNGVAQTVRAGARLPGSAAAAVQTLASPVLE
LTGPVVQSVVQTTGRAIGVRGSHNESPDGMTPPVRWRSGRRVHFDLDPLLPFPRWHEH
AAMVEEPVRRIPGVAEAHVEGSLGRLVVELEPDADSDIAVDEVRDVVSAVAADIFLAG
SVSSPNSAPFADPGNPLAILVPLTAAAMDLVAMGATVTGWVARLPAAPQTTRALAALI
NHQPRMVSLMESRLGRVGTDIALAATTAAANGLTQSLGTPLLDLVQRSLQISEAAAHR
RVWRDREPALASPRRPQAPVVPIISSAGAKSQEPRHSWAAAAAGEASHVVVGGSIDAA
IDTAKGSRAGPVEQYVNQAANGSLIAAASALVAGGGTEDAAGAILAGVPRAAHMGRQA
FAAVLGRGLANTGQLVLDPGALRRLDRVRVVVIDGAALRGDNRAVLHAQGDEPGWDDD
RVYEVADALLHGEQAPEPDPDELPATGARLRWAPAQGPSATPAQGLEHADLVVDGQCV
GSVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVGSTHPPGTPLLKLVRE
LRADRGPVLLITAVHRDFASTDTLAALAIADVGVALDDPRGATPWTADLITGTDLAAA
VRILSALPVARAASESAVHLAQGGTTLAGLLLVTGEQDKTTNPASFRRWLNPVNAAAA
TALVSGMWSAAKVLRMPDPTPQPLTAWHALDPEIVYSRLAGGSRPLAVEPGIPAWRRI
LDDLSYEPVMAPLRGPARTLAQLAVATRHELADPLTPILAVGAAASAIVGSNIDALLV
AGVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTRRRLEAARHATRTA
TVSAKSLRVGDVIDLAAPEVVPADARLLVAEDLEVDESFLTGESLPVDKQVDPVAVND
PDRASMLFEGSTIVAGHARAIVVATGVGTAAHRAISAVADVETAAGVQARLRELTSKV
LPMTLAGGAAVTALALLRRASLRQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTA
RGALVRSPRTIEALGRVDTICFDKTGTLTENRLRVVCALPSSTAAERDPLPQTTDAPS
AEVLRAAARASTQPHNGEGHAHATDEAILAAASALAGSLSSQGDSEWVVLAEVPFESS
RGYAAAIGRVGTDGIPMLMLKGAPETILPRCRLADPGVDHEHAESVVRHLAEQGLRVL
AVAQRTWDNGTTHDDETDADAVDAVAHDLELIGYVGLADTARSSSRPLIEALLDAERN
VVLITGDHPITARAIARQLGLPADARVVTGAELAVLDEEAHAKLAADMQVFARVSPEQ
KVQIVAALQRCGRVTAMVGDGANDAAAIRMADVGIGVSGRGSSAARGAADIVLTDDDL
GVLLDALVEGRSMWAGVRDAVTILVGGNVGEVLFTVIGTAFGAGRAPVGTRQLLLVNL
LTDMFPALAVAVTSQFAEPDDAEYPTDDAAERAQREHRRAVLIGPTPSLDAPLLRQIV
NRGVVTAAGATAAWAIGRWTPGTERRTATMGLTALVMTQLAQTLLTRRHSPLVIATAL
GSAGVLVGIIQTPVISHFSGVPRWDRSPGRASSAPRQEPPQSQRWHRSGWQAQSVSCN
LMNALTTRKTLTRVDRTYRRPR"
gene complement(130895..131104)
/locus_tag="Rv0108c"
CDS complement(130895..131104)
/codon_start=1
/transl_table=11
/locus_tag="Rv0108c"
/product="Hypothetical protein"
/note="Rv0108c, (MTV031.02c), len: 69 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0108c"
/db_xref="EnsemblGenomes-Tr:CCP42833"
/db_xref="GOA:O53630"
/db_xref="UniProtKB/TrEMBL:O53630"
/protein_id="CCP42833.1"
/translation="MVPVETLHSGDPITDVNGGGQRYIVLESKTVGDSCVVLELESRV
NHQLQVIEKSFPAGYHVGRAHHRIL"
gene 131382..132872
/gene="PE_PGRS1"
/locus_tag="Rv0109"
CDS 131382..132872
/codon_start=1
/transl_table=11
/gene="PE_PGRS1"
/locus_tag="Rv0109"
/product="PE-PGRS family protein PE_PGRS1"
/note="Rv0109, (MTV031.03c), len: 496 aa. PE_PGRS1, Member
of the M. tuberculosis PE family, PGRS subfamily of
gly-rich proteins (see Brennan and Delogu, 2002), highly
similar to many e.g. Q50615|Y0DP_MYCTU hypothetical
glycine-rich 40.8 kDa protein from Mycobacterium
tuberculosis (498 aa), FASTA scores: opt: 1772, E():
0,(57.3% identity in 513 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0109"
/db_xref="EnsemblGenomes-Tr:CCP42834"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L0T2H7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42834.1"
/translation="MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGA
DEVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQ
TVQQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQA
GGNGGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPG
GAGGNAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADG
GLGGGGGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGG
LAGIGGNAGFVRNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGN
GGMGGNAVGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAA
SAGGNGGNARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS"
gene 133020..133769
/locus_tag="Rv0110"
CDS 133020..133769
/codon_start=1
/transl_table=11
/locus_tag="Rv0110"
/product="Probable conserved integral membrane protein"
/note="Rv0110, (MTV031.04), len: 249 aa. Probable
conserved integral membrane protein, similar to many e.g.
AL079308|SCH69_25 from Streptomyces coelicolor (297
aa),FASTA scores: opt: 552, E(): 6.1e-29, (45.4% identity
in 251 aa overlap); P54493|YQGP_BACSU hypothetical 56.4 KD
protein from Bacillus subtilis (507 aa), FASTA scores:
opt: 320, E(): 4e-15, (32.4% identity in 210 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv0110"
/db_xref="EnsemblGenomes-Tr:CCP42835"
/db_xref="GOA:O53632"
/db_xref="InterPro:IPR022764"
/db_xref="InterPro:IPR035952"
/db_xref="UniProtKB/TrEMBL:O53632"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42835.1"
/translation="MRVGPVGHQCAECVREGARAVRQPRTPFGGRQRSATPVVTYTLI
SLNALVFVMQVTVMGLERQLALWPPAVASGQTYRLVTSAFLHYGAMHLLLNMWALYVV
GPPLEMWLGRLRFGALYAVSALGGSVLVYLIAPLNTATAGASGAVFGLFGATFMVARR
LHLDVRWVVALIVINLAFTFLAPAISWQGHVGGLVTGALVAATYVYAPRERRNLIQAT
VTITVLVAFVVLIGWRTVDLLALFGGRLNLS"
gene 133950..136007
/locus_tag="Rv0111"
CDS 133950..136007
/codon_start=1
/transl_table=11
/locus_tag="Rv0111"
/product="Possible transmembrane acyltransferase"
/note="Rv0111, (MTV031.05), len: 685 aa. Possible
transmembrane acyltransferase, equivalent to
AA22904.1|AL035300 putative acyltransferase from
Mycobacterium leprae (696 aa). Also similar to others e.g.
C69975 acyltransferase homolog yrhL from Bacillus subtilis
(634 aa), FASTA scores: opt: 520, E(): 4e-22, (36.4%
identity in 382 aa overlap). Very similar to Mycobacterium
tuberculosis proteins Rv0228, Rv1254, Rv1565c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0111"
/db_xref="EnsemblGenomes-Tr:CCP42836"
/db_xref="GOA:O53633"
/db_xref="InterPro:IPR002656"
/db_xref="InterPro:IPR036514"
/db_xref="UniProtKB/TrEMBL:O53633"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42836.1"
/translation="MPARSVPRPRWVAPVRRVGRLAVWDRPERRSGIPALDGLRAIAV
ALVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFWIRRARRL
LPALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFVAQNTDYFTQGAPPSP
LQHTWSLGVEEQYYVVWPLLLIGATLLLAARARRRCRRATVGGVRFAAFLIASLGTMA
SATAAVAFTSAATRDRIYFGTDTRAQALLIGSAAAALLVRDWPSLNRGWCLIRTRWGR
RIARLLPFVGLAGLAVTTHVATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARI
LAWRPLVWLGTISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLI
EQPIRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAVAAVSP
SPPEASQPAPGPRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFRFIDHTVIGCSLVRGT
PYRYIGQTLEQRAECDGWPARWSAQVNRDQPDVALLIVGRWETVDRVNEGRWTHIGDP
TFDAYLNAELQRALSIVGSTGVRVMVTTVPYSRGGEKPDGRLYPEDQPERVNKWNAML
HNAISQHSNVGMIDLNKKLCPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVR
VAS"
gene 136289..137245
/gene="gca"
/locus_tag="Rv0112"
CDS 136289..137245
/codon_start=1
/transl_table=11
/gene="gca"
/locus_tag="Rv0112"
/product="Possible GDP-mannose 4,6-dehydratase Gca
(GDP-D-mannose dehydratase)"
/note="Rv0112, (MTV031.06), len: 318 aa. Possible
gca,GDP-mannose 4,6-dehydratase, similar to others e g.
U18320|PAU18320_1 GDP-D-mann from Pseudomonas aeruginosa
(323 aa), FASTA scores: opt: 415, E(): 4.4e-21, (27.0%
identity in 318 aa overlap). Similar to Rv3634c,
Rv3784,etc from Mycobacterium tuberculosis. Contains
PS00061 Short-chain dehydrogenases/reductases family
signature. Seems to belong to the GDP-mannose
4,6-dehydratase family. Cofactor: NAD(+). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0112"
/db_xref="EnsemblGenomes-Tr:CCP42837"
/db_xref="GOA:O53634"
/db_xref="InterPro:IPR016040"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53634"
/inference="protein motif:PROSITE:PS00061"
/protein_id="CCP42837.1"
/translation="MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFN
GAEVDITDWCSVYDSIATFRPDAVFHLAAQSYPAVSWARPVETLTTNMVGTAIVFEAL
RRVRPHAKIIVAGSSAEYGFVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSY
GMHTVVARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRDL
NRALMLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEK
IIYGDCSKLAAITGWQQEICLTQTIADMFDYWRSKSESALMV"
gene 137319..137909
/gene="gmhA"
/gene_synonym="lpcA"
/locus_tag="Rv0113"
CDS 137319..137909
/codon_start=1
/transl_table=11
/gene="gmhA"
/gene_synonym="lpcA"
/locus_tag="Rv0113"
/product="Probable sedoheptulose-7-phosphate isomerase
GmhA (phosphoheptose isomerase)"
/note="Rv0113, (MTV031.07), len: 196 aa. Probable gmhA
(alternate gene name: lpcA), sedoheptulose-7-phosphate
isomerase (see citation below), similar to many e.g.
AE0005|HPAE000596_11 from Helicobacter pylori (192
aa),FASTA scores: opt: 451, E(): 1.9e-24, (45.1% identity
in 162 aa overlap). Belongs to the sis family, LPCA
subfamily. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0113"
/db_xref="EnsemblGenomes-Tr:CCP42838"
/db_xref="GOA:P9WGG1"
/db_xref="InterPro:IPR001347"
/db_xref="InterPro:IPR004515"
/db_xref="InterPro:IPR035461"
/db_xref="UniProtKB/Swiss-Prot:P9WGG1"
/protein_id="CCP42838.1"
/translation="MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRA
GARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTV
FARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADF
LINVPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ"
gene 137941..138513
/gene="gmhB"
/locus_tag="Rv0114"
CDS 137941..138513
/codon_start=1
/transl_table=11
/gene="gmhB"
/locus_tag="Rv0114"
/product="Possible D-alpha,beta-D-heptose-1,7-biphosphate
phosphatase GmhB (D-glycero-D-manno-heptose 7-phosphate
kinase)"
/note="Rv0114, (MTV031.08), len: 190 aa. Possible
gmhB,D-alpha,beta-D-heptose-1,7-biphosphate phosphatase
(see citation below), similar to several hypothetical
proteins and phosphatases e.g. HIS7_ECOLI|P06987
imidazoleglycerol-phosphate dehydratase (355 aa), FASTA
scores: opt: 250, E(): 3.6e-11, (34.0 % identity in 141 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0114"
/db_xref="EnsemblGenomes-Tr:CCP42839"
/db_xref="GOA:P9WMV3"
/db_xref="InterPro:IPR004446"
/db_xref="InterPro:IPR006543"
/db_xref="InterPro:IPR006549"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WMV3"
/protein_id="CCP42839.1"
/translation="MVAERAGHQWCLFLDRDGVINRQVVGDYVRNWRQFEWLPGAARA
LKKLRAWAPYIVVVTNQQGVGAGLMSAVDVMVIHRHLQMQLASDGVLIDGFQVCPHHR
SQRCGCRKPRPGLVLDWLGRHPDSEPLLSIVVGDSLSDLELAHNVAAAAGACASVQIG
GASSGGVADASFDSLWEFAVAVGHARGERG"
gene 138513..139673
/gene="hddA"
/locus_tag="Rv0115"
CDS 138513..139673
/codon_start=1
/transl_table=11
/gene="hddA"
/locus_tag="Rv0115"
/product="Possible D-alpha-D-heptose-7-phosphate kinase
HddA"
/note="Rv0115, (MTV031.09), len: 386 aa. Possible
hddA,D-alpha-D-heptose-7-phosphate kinase (see citation
below),similar to several hypothetical proteins and sugar
kinases e.g. AAK27850.1|AF324836_3
D-glycero-D-manno-heptose 7-phosphate kinase from
Aneurinibacillus thermoaerophilus (341 aa);
AAK80995.1|AE007802_11 Sugar kinase from Clostridium
acetobutylicum (364 aa). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0115"
/db_xref="EnsemblGenomes-Tr:CCP42840"
/db_xref="GOA:O53637"
/db_xref="InterPro:IPR001174"
/db_xref="InterPro:IPR006204"
/db_xref="InterPro:IPR013750"
/db_xref="InterPro:IPR014606"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR036554"
/db_xref="UniProtKB/TrEMBL:O53637"
/inference="protein motif:PROSITE:PS00435"
/protein_id="CCP42840.1"
/translation="MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAF
AERGTGDEIAFRSPDRDRAGQASIDDLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQL
ATQVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQ
DHYAAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQ
QRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNP
AIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFT
KGGAVTWHIPESTAPVRRGVADAVASALGNAGILLCAGCVLATSHSTWRVPV"
gene complement(140267..141022)
/gene="ldtA"
/locus_tag="Rv0116c"
CDS complement(140267..141022)
/codon_start=1
/transl_table=11
/gene="ldtA"
/locus_tag="Rv0116c"
/product="Probable L,D-transpeptidase LdtA"
/note="Rv0116c, (MTV031.10c), len: 251 aa. Probable
ldtA,L,D-transpeptidase, showing similarity to several
hypothetical mycobacterial proteins e.g. Rv1433 from
Mycobacterium tuberculosis (271 aa); and
Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271
aa); to the C-terminal regions of others like Rv0192 from
Mycobacterium tuberculosis (366 aa), FASTA scores: opt:
451, E(): 1.7e-21, (46.7% identity in 270 aa overlap); and
Rv0192|Z97050|MTCI28_32 from Mycobacterium tuberculosis
cosmid (366 aa), FASTA scores: opt: 699, E(): 0, (45.7%
identity in 221 aa overlap). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0116c"
/db_xref="EnsemblGenomes-Tr:CCP42841"
/db_xref="GOA:O53638"
/db_xref="InterPro:IPR005490"
/db_xref="InterPro:IPR038063"
/db_xref="InterPro:IPR041280"
/db_xref="PDB:4JMN"
/db_xref="PDB:4JMX"
/db_xref="PDB:5E51"
/db_xref="PDB:5E5L"
/db_xref="UniProtKB/Swiss-Prot:O53638"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42841.1"
/translation="MRRVVRYLSVVVAITLMLTAESVSIATAAVPPLQPIPGVASVSP
ANGAVVGVAHPVVVTFTTPVTDRRAVERSIRISTPHNTTGHFEWVASNVVRWVPHRYW
PPHTRVSVGVQELTEGFETGDALIGVASISAHTFTVSRNGEVLRTMPASLGKPSRPTP
IGSFHAMSKERTVVMDSRTIGIPLNSSDGYLLTAHYAVRVTWSGVYVHSAPWSVNSQG
YANVSHGCINLSPDNAAWYFDAVTVGDPIEVVG"
gene 141200..142144
/gene="oxyS"
/locus_tag="Rv0117"
CDS 141200..142144
/codon_start=1
/transl_table=11
/gene="oxyS"
/locus_tag="Rv0117"
/product="Oxidative stress response regulatory protein
OxyS"
/note="Rv0117, (MTV031.11), len: 314 aa. OxyS, oxidative
stress response protein regulatory protein, LysR family
(see citation below). Similar to many transcription
regulators and OxyR, the oxidative stress response protein
of many bacteria. Contains LysR family signature at
N-terminus. Also contains helix-turn-helix motif at aa
16-37 (Score 1543, +4.44 SD). Belongs to the LysR family
of transcriptional regulators. OXYR is required for the
induction of a regulon of hydrogen peroxide inducible
genes such as catalase, glutathione-reductase, etc."
/db_xref="EnsemblGenomes-Gn:Rv0117"
/db_xref="EnsemblGenomes-Tr:CCP42842"
/db_xref="GOA:L7N677"
/db_xref="InterPro:IPR000847"
/db_xref="InterPro:IPR005119"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:L7N677"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42842.1"
/translation="MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELN
VTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTAS
TTASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSDDVDLVP
LYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQVIDAAFADHAVSAIP
QVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALA
TNALGPGSPVARALITCAQALALNEFFDTQLRGITRRR"
gene complement(142128..143876)
/gene="oxcA"
/locus_tag="Rv0118c"
CDS complement(142128..143876)
/codon_start=1
/transl_table=11
/gene="oxcA"
/locus_tag="Rv0118c"
/product="Probable oxalyl-CoA decarboxylase OxcA"
/note="Rv0118c, (MTV031.12c), Len: 582 aa. Probable
oxcA,oxalyl-CoA decarboxylase, highly similar to many e.g.
P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325
probable oxalyl-CoA decarboxylase from Escherichia coli
(564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from
Oxalobacter formigenes (568 aa), FASTA scores: opt:
2124,E():0, (55.6% identity in 568 aa overlap). Also
similar to mycobacterial IlvB proteins e.g. MLCB1788.46c
unknown TPP-requiring enzyme from Mycobacterium leprae
(548 aa); and AL0086|MLCB1788_19 from Mycobacterium leprae
(548 aa),FASTA scores: opt: 831, E(): 0, (33.9% identity
in 567 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0118c"
/db_xref="EnsemblGenomes-Tr:CCP42843"
/db_xref="GOA:O53639"
/db_xref="InterPro:IPR011766"
/db_xref="InterPro:IPR012000"
/db_xref="InterPro:IPR012001"
/db_xref="InterPro:IPR017660"
/db_xref="InterPro:IPR029035"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/TrEMBL:O53639"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42843.1"
/translation="MTTRSASPCTVLTDGCHLVVDALKANDVDTIYGVVGIPITDLAR
AAQASGIRYIGFRHEASAGNAAAAAGFLTARPGVCLTTSGPGFLNGLPALANATTNCF
PMIQISGSSSRPMVDLQRGDYQDLDQLNAARPFVKAAYRIGQVQDIGRGVARAIRTAT
SGRPGGVYLDIPGDVLGQAVEASAASGAIWRPVDPAPRLLPAPEAIDRALDVLAQAQR
PLLVLSKGAAYAQADNVIREFVEHTGIPFLPMSMAKGLLPDSHPQSAAAARSLAMARA
DVVLLVGARLNWLLGNGESPQWSADAKFIQVDIEASEFDSNRPIVAPLTGDIGSVMSA
LLEAAADRSSVASAAWTGELADRKARNSAKMRRRLADDHHPMRFYNALGAIRSVLQRN
PDVYVVNEGANALDLARNIIDMHLPRHRLDSGTWGVMGIGMGYAIAAAVETGRPVVAI
EGDSAFGFSGMEFETICRYRLPVTVVILNNGGVYRGDEATIFRSAAPVWRHDPAPTVL
NAHARHELIAEAFGGKGYHVSTPTELESALTDALASNGPSLIDCELDPADGVESGHLA
KLNTTSAATPAISGDG"
gene 144049..145626
/gene="fadD7"
/locus_tag="Rv0119"
CDS 144049..145626
/codon_start=1
/transl_table=11
/gene="fadD7"
/locus_tag="Rv0119"
/product="Probable fatty-acid-CoA ligase FadD7
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0119, (MTV031.13-MTCI418B.01), len: 525 aa.
Probable fadD7, fatty-acid-CoA synthetase, similar to
4-coumarate:CoA ligase of many organisms e.g.
U39405|PTU39405_1 4-coumarate:CoA ligase from Pinus
taedaxylem (537 aa), FASTA scores: opt: 483, E():
8.3e-22,(28.2% identity in 440 aa overlap). Contains
PS00455 Putative AMP-binding domain signature."
/db_xref="EnsemblGenomes-Gn:Rv0119"
/db_xref="EnsemblGenomes-Tr:CCP42844"
/db_xref="GOA:O07169"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O07169"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42844.1"
/translation="MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLV
DELAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRS
QAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATS
TPEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVAVMPLY
HGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERS
ATEPSGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMTEATHQVTTTQIEG
IDQTETPVVSTGLVGRSTGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTIT
AANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEA
AVFGVPHQLYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTA
KGSLDRRAVAERFGHSV"
gene complement(145627..147771)
/gene="fusA2"
/gene_synonym="fus2"
/locus_tag="Rv0120c"
CDS complement(145627..147771)
/codon_start=1
/transl_table=11
/gene="fusA2"
/gene_synonym="fus2"
/locus_tag="Rv0120c"
/product="Probable elongation factor G FusA2 (EF-G)"
/note="Rv0120c, (MTCI418B.02c), len: 714 aa. Probable
fusA2 (alternate gene name: fus2), elongation factor G,
highly similar to others e.g. EFG_ECOLI|P02996 elongation
factor G (ef-g) from Escherichia coli (703 aa), FASTA
scores: opt: 1049, E(): 0, (32.5% identity in 717 aa
overlap). Also similar to fusA1|MTCY210.01 from
Mycobacterium tuberculosis FASTA score: (39.1% identity in
299 aa overlap); and P30767|EFG_MYCLE elongation factor G
(EF-G) from Mycobacterium leprae (701 aa), FASTA score:
(31.7% identity in 710 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
GTP-binding elongation factor family, EF-G/EF-2
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0120c"
/db_xref="EnsemblGenomes-Tr:CCP42845"
/db_xref="GOA:P9WNM9"
/db_xref="InterPro:IPR000640"
/db_xref="InterPro:IPR000795"
/db_xref="InterPro:IPR004161"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR005517"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR009022"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR035647"
/db_xref="InterPro:IPR035649"
/db_xref="InterPro:IPR041095"
/db_xref="UniProtKB/Swiss-Prot:P9WNM9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42845.1"
/translation="MADRVNASQGAAAAPTANGPGGVRNVVLVGPSGGGKTTLIEALL
VAAKVLSRPGSVTEGTTVCDFDEAEIRQQRSVGLAVASLAYDGIKVNLVDTPGYADFV
GELRAGLRAADCALFVIAANEGVDEPTKSLWQECSQVGMPRAVVITKLDHARANYREA
LTAAQDAFGDKVLPLYLPSGDGLIGLLSQALYEYADGKRTTRTPAESDTERIEEARGA
LIEGIIEESEDESLMERYLGGETIDESVLIQDLEKAVARGSFFPVIPVCSSTGVGTLE
LLEVATRGFPSPMEHPLPEVFTPQGVPHAELACDNDAPLLAEVVKTTSDPYVGRVSLV
RVFSGTIRPDTTVHVSGHFSSFFGGGTSNTHPDHDEDERIGVLSFPLGKQQRPAAAVV
AGDICAIGKLSRAETGDTLSDKAEPLVLKPWTMPEPLLPIAIAAHAKTDEDKLSVGLG
RLAAEDPTLRIEQNQETHQVVLWCMGEAHAGVVLDTLANRYGVSVDTIELRVPLRETF
AGNAKGHGRHIKQSGGHGQYGVCDIEVEPLPEGSGFEFLDKVVGGAVPRQFIPNVEKG
VRAQMDKGVHAGYPVVDIRVTLLDGKAHSVDSSDFAFQMAGALALREAAAATKVILLE
PIDEISVLVPDDFVGAVLGDLSSRRGRVLGTETAGHDRTVIKAEVPQVELTRYAIDLR
SLAHGAASFTRSFARYEPMPESAAARVKAGAG"
gene complement(147908..148342)
/locus_tag="Rv0121c"
CDS complement(147908..148342)
/codon_start=1
/transl_table=11
/locus_tag="Rv0121c"
/product="Conserved protein"
/note="Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved
protein, showing some similarity with others proteins from
Mycobacterium tuberculosis e.g. Rv1155, Rv1875,
Rv2074,etc."
/db_xref="EnsemblGenomes-Gn:Rv0121c"
/db_xref="EnsemblGenomes-Tr:CCP42846"
/db_xref="GOA:O07171"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR019967"
/db_xref="UniProtKB/TrEMBL:O07171"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42846.1"
/translation="MGEFDPKLRFAQSPVARLATSTPDGTPHLVPVVFALGARRPAEA
TGADVIYTAVDAKRKTTQRLRRLANLEHNPRASVLVDSYADDWTQLWWVRADGVAAIH
RDGEVMRAAYRLLRAKYAQYQSVPLNGPVIAIAVQRWASWHA"
gene 148491..148859
/locus_tag="Rv0122"
CDS 148491..148859
/codon_start=1
/transl_table=11
/locus_tag="Rv0122"
/product="Hypothetical protein"
/note="Rv0122, (MTCI418B.04), len: 122 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0122"
/db_xref="EnsemblGenomes-Tr:CCP42847"
/db_xref="GOA:O07172"
/db_xref="UniProtKB/TrEMBL:O07172"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42847.1"
/translation="MAGSVSAAAGIGWVGLNVTETNRDQCYRVERTTVDALTHPEYRV
HTRGVQRVRVTRNARKHRVSKHRIVAAMRHCGVPVIQEDGSLYYQGRDTSGRLTEVVA
VEADDGDLIITHAMPKEWKR"
gene 148856..149224
/locus_tag="Rv0123"
CDS 148856..149224
/codon_start=1
/transl_table=11
/locus_tag="Rv0123"
/product="Unknown protein"
/note="Rv0123, (MTCI418B.05), len: 122 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv0123"
/db_xref="EnsemblGenomes-Tr:CCP42848"
/db_xref="GOA:O07173"
/db_xref="UniProtKB/TrEMBL:O07173"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42848.1"
/translation="MTKKPRNPADYVIGDDVEVSDVDLKQEEVYVDGERLTDERVEQM
ASESLRLAREREANLIPGGKSLSGGSAHSPAVQVVVSKATHAKLKELARSRKMSVSKL
LRPVLDEFVQRETGRILPRR"
gene 149533..150996
/gene="PE_PGRS2"
/locus_tag="Rv0124"
CDS 149533..150996
/codon_start=1
/transl_table=11
/gene="PE_PGRS2"
/locus_tag="Rv0124"
/product="PE-PGRS family protein PE_PGRS2"
/note="Rv0124, (MTCI418B.06), len: 487 aa. PE_PGRS2,
Member of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan and Delogu,
2002), highly similar to many e.g. Y0DP_MYCTU|Q50615 from
Mycobacterium tuberculosis (498 aa), FASTA scores: opt:
1730, E(): 0,(60.7% identity in 504 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0124"
/db_xref="EnsemblGenomes-Tr:CCP42849"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79G08"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42849.1"
/translation="MSFVSVAPEIVVAAATDLAGIGSAISAANAAAAAPTTAVLAAGA
DEVSAAIAALFSGHAQAYQALSAQAAAFHQQFVQTLAGGAGAYAAAEAQVEQQLLAAI
NAPTQALLGRPLIGNGADGAPGTGQAGGAGGILYGNGGNGGSGAAGQAGGAGGPAGLI
GHGGSGGAGGSGAAGGAGGHGGWLWGNGGVGGSGGAGVGAGVAGGHGGAGGAAGLWGA
GGGGGNGGNGADANIVSGGDGGLGGAGGGGGWLYGDGGAGGHGGQGAIGLGGGAGGDG
GQGGAGRGLWGTGGAGGHGGQGGGTGGPPLPGQAGMGAAGGAGGLIGNGGAGGDGGVG
ASGGVAGVGGAGGNAMLIGHGGAGGAGGDSSFANGAAGGAGGAGGHLFGNGGSGGHGG
AVTAGNTGIGGAGGVGGDARLIGHGGAGGAGGDRAGALVGRDGGPGGNGGAGGQLYGN
GGDGAPGTGGTLQAAVSGLVTALFGAPGQPGDTGQPG"
gene 151148..152215
/gene="pepA"
/gene_synonym="mtb32a"
/locus_tag="Rv0125"
CDS 151148..152215
/codon_start=1
/transl_table=11
/gene="pepA"
/gene_synonym="mtb32a"
/locus_tag="Rv0125"
/product="Probable serine protease PepA (serine
proteinase) (MTB32A)"
/note="Rv0125, (MTCI418B.07, MTB32A), len: 355 aa.
Probable pepA (alternate gene name: mtb32a), serine
protease (see Skeiky et al., 1999), highly similar to
other proteases e.g. HHOB_ECOLI|P31137 protease hhob
precursor (355 aa),FASTA scores: opt: 400, E(): 3.8e-14,
(32.4% identity in 346 aa overlap). Also similar to Q50320
34 kDa protein precursor from Mycobacterium tuberculosis
(361 aa), FASTA scores: opt: 1689, E(): 0, (70.7% identity
in 362 aa overlap). Contains PS00135 Serine proteases,
trypsin family, serine active site. Has a putative signal
sequence at the N-terminus. Belongs to the serine protease
family. Conserved in M. tuberculosis, M. leprae, M. bovis
and M. avium paratuberculosis; predicted to be essential
for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0125"
/db_xref="EnsemblGenomes-Tr:CCP42850"
/db_xref="GOA:O07175"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR001940"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR036034"
/db_xref="UniProtKB/TrEMBL:O07175"
/inference="protein motif:PROSITE:PS00135"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42850.1"
/translation="MSNSRRRSLRWSWLLSVLAAVGLGLATAPAQAAPPALSQDRFAD
FPALPLDPSAMVAQVGPQVVNINTKLGYNNAVGAGTGIVIDPNGVVLTNNHVIAGATD
INAFSVGSGQTYGVDVVGYDRTQDVAVLQLRGAGGLPSAAIGGGVAVGEPVVAMGNSG
GQGGTPRAVPGRVVALGQTVQASDSLTGAEETLNGLIQFDAAIQPGDSGGPVVNGLGQ
VVGMNTAASDNFQLSQGGQGFAIPIGQAMAIAGQIRSGGGSPTVHIGPTAFLGLGVVD
NNGNGARVQRVVGSAPAASLGISTGDVITAVDGAPINSATAMADALNGHHPGDVISVT
WQTKSGGTRTGNVTLAEGPPA"
gene 152324..154129
/gene="treS"
/locus_tag="Rv0126"
CDS 152324..154129
/codon_start=1
/transl_table=11
/gene="treS"
/locus_tag="Rv0126"
/product="Trehalose synthase TreS"
/note="Rv0126, (MTCI418B.08), len: 601 aa. TreS, trehalose
synthase (see citation below), highly similar to others
e.g. CAA04601.2|AJ001205 putative trehalose synthase from
Streptomyces coelicolor (566 aa);
S71450|1536814|BAA11303.1|D78198 trehalose synthase
maltose-specific from Pimelobacter sp. strain R48 (573
aa). Also similar to MAL1_DROME|P07191 possible maltase
precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7%
identity in 504 aa overlap); and similar to proteins
associated with amino-acid transport e.g. Q64319 rat
protein which stimulates transport of cystine and dibasic
and neutral amino acids (683 aa), FASTA scores: opt:
839,E(): 0, (32.0% identity in 531 aa overlap). Also
similar to several other Mycobacterium tuberculosis
proteins e.g. Rv2471 FASTA score: (31.7% identity in 164
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0126"
/db_xref="EnsemblGenomes-Tr:CCP42851"
/db_xref="GOA:P9WQ19"
/db_xref="InterPro:IPR006047"
/db_xref="InterPro:IPR012810"
/db_xref="InterPro:IPR013780"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR032091"
/db_xref="UniProtKB/Swiss-Prot:P9WQ19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42851.1"
/translation="MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWF
KHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYD
IRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPY
GDYYVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQE
AMIDVIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRV
LLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTP
PIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDND
RNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTAN
PGRLYLPPSQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGG
SNPSVLAYVRQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIG
QVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL"
repeat_region 154073..154125
/gene="treS"
/locus_tag="Rv0126"
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class III (see Supply et al., 1997)"
repeat_region 154126..154178
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region 154179..154231
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 154232..155599
/gene="mak"
/locus_tag="Rv0127"
CDS 154232..155599
/codon_start=1
/transl_table=11
/gene="mak"
/locus_tag="Rv0127"
/product="Maltokinase Mak"
/note="Rv0127, (MTCI418B.09, MTCI5.01), len: 455 aa.
Mak,maltokinase; highly similar to various proteins e.g.
AJ0012|SCJ001205_4 hypothetical protein from Streptomyces
coelicolor A3(2) (464 aa), FASTA scores: opt: 412, E():
1.1e-19, (40.6% identity in 485 aa overlap);
AJ0012|SCJ001206_5 hypothetical protein from Streptomyces
coelicolor A3(2) (453 aa), FASTA scores: opt: 403, E():
4.3 e-19, (36.5% identity in 455 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0127"
/db_xref="EnsemblGenomes-Tr:CCP42852"
/db_xref="GOA:O07177"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR040999"
/db_xref="PDB:4O7O"
/db_xref="PDB:4O7P"
/db_xref="UniProtKB/Swiss-Prot:O07177"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42852.1"
/translation="MTRSDTLATKLPWSDWLSRQRWYAGRNRELATVKPGVVVALRHN
LDLVLVDVTYTDGATERYQVLVGWDFEPASEYGTKAAIGVADDRTGFDALYDVAGPQF
LLSLIVSSAVCGTSTGEVTFTREPDVELPFAAQPRVCDAEQSNTSVIFDRRAILKVFR
RVSSGINPDIELNRVLTRAGNPHVARLLGAYQFGRPNRSPTDALAYALGMVTEYEANA
AEGWAMATASVRDLFAEGDLYAHEVGGDFAGESYRLGEAVASVHATLADSLGTAQATF
PVDRMLARLSSTVAVVPELREYAPTIEQQFQKLAAEAITVQRVHGDLHLGQVLRTPES
WLLIDFEGEPGQPLDERRAPDSPLRDVAGVLRSFEYAAYGPLVDQATDKQLAARAREW
VERNRAAFCDGYAVASGIDPRDSALLLGAYELDKAVYETGYETRHRPGWLPIPLRSIA
RLTAS"
gene 155667..156446
/locus_tag="Rv0128"
CDS 155667..156446
/codon_start=1
/transl_table=11
/locus_tag="Rv0128"
/product="Probable conserved transmembrane protein"
/note="Rv0128, (MTCI5.02), len: 259 aa. Probable conserved
transmembrane protein, with some similarity to Rv3064c and
other bacterial proteins e.g.
AAK85977.1|AE007957|AGR_C_254p from Agrobacterium
tumefaciens (206 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0128"
/db_xref="EnsemblGenomes-Tr:CCP42853"
/db_xref="GOA:P96805"
/db_xref="InterPro:IPR010699"
/db_xref="UniProtKB/TrEMBL:P96805"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42853.1"
/translation="MQREIYDGEARLSWVLAALAGILGATAFTHSAGYFVTFMTGNSQ
RAVLGLFGDDAWMSVTASLLILFFVAGVVIASVCRRHFWAAHPHGPTVLTTFSLIFAA
GVDIMLGGWHESMLDFVPILFVVFGIGALNTSFVKDGEVSVPLSYVTGTLVKMGQGIE
RHLAGGKVEDWLGYFLLHASFVLGAAAGGAISMVVTGPQMLAVAAVVCAATTGYTYLH
ADRRGLVNQKRPQPGKRLFRALRRGELDSGTSTPATNYGSS"
gene complement(156578..157600)
/gene="fbpC"
/gene_synonym="85C"
/gene_synonym="fbpC2"
/gene_synonym="mpt45"
/locus_tag="Rv0129c"
CDS complement(156578..157600)
/codon_start=1
/transl_table=11
/gene="fbpC"
/gene_synonym="85C"
/gene_synonym="fbpC2"
/gene_synonym="mpt45"
/locus_tag="Rv0129c"
/product="Secreted antigen 85-C FbpC (85C) (antigen 85
complex C) (AG58C) (mycolyl transferase 85C)
(fibronectin-binding protein C)"
/note="Rv0129c, (MT0137, MTCI5.03c), len: 340 aa. FbpC
(alternate gene names: mpt45, 85C, fbpC2), secreted
antigen 85c (fibronectin-binding protein C) (mycolyl
transferase 85C) (see citations below), also highly
similar to other Mycobacterial antigen precursors e.g.
A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from
Mycobacterium leprae (333 aa), FASTA scores: opt: 1937,
E(): 0, (81.4% identity in 333 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0129c"
/db_xref="EnsemblGenomes-Tr:CCP42854"
/db_xref="GOA:P9WQN9"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:1DQY"
/db_xref="PDB:1DQZ"
/db_xref="PDB:1VA5"
/db_xref="PDB:3HRH"
/db_xref="PDB:4MQL"
/db_xref="PDB:4MQM"
/db_xref="PDB:4QDO"
/db_xref="PDB:4QDT"
/db_xref="PDB:4QDU"
/db_xref="PDB:4QDX"
/db_xref="PDB:4QDZ"
/db_xref="PDB:4QE3"
/db_xref="PDB:4QEK"
/db_xref="PDB:5KWI"
/db_xref="PDB:5KWJ"
/db_xref="PDB:5OCJ"
/db_xref="UniProtKB/Swiss-Prot:P9WQN9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42854.1"
/translation="MTFFEQVRRLRSAATTLPRRLAIAAMGAVLVYGLVGTFGGPATA
GAFSRPGLPVEYLQVPSASMGRDIKVQFQGGGPHAVYLLDGLRAQDDYNGWDINTPAF
EEYYQSGLSVIMPVGGQSSFYTDWYQPSQSNGQNYTYKWETFLTREMPAWLQANKGVS
PTGNAAVGLSMSGGSALILAAYYPQQFPYAASLSGFLNPSEGWWPTLIGLAMNDSGGY
NANSMWGPSSDPAWKRNDPMVQIPRLVANNTRIWVYCGNGTPSDLGGDNIPAKFLEGL
TLRTNQTFRDTYAADGGRNGVFNFPPNGTHSWPYWNEQLVAMKADIQHVLNGATPPAA
PAAPAA"
gene 157847..158302
/gene="htdZ"
/locus_tag="Rv0130"
CDS 157847..158302
/codon_start=1
/transl_table=11
/gene="htdZ"
/locus_tag="Rv0130"
/product="Probable 3-hydroxyl-thioester dehydratase"
/note="Rv0130, (MTCI5.04), len: 151 aa. Probable
htdZ,3-hydroxyl-thioester dehydratase. Forms single
hot-dog fold, features R-specific hydratase motif,
substrate unknown, forms homodimer. Shows structural
similarity to six others in Mycobacterium tuberculosis
(see Castell et al (2005) below). Similar to others e.g.
AL096811|SCI30A_19 from Streptomyces coelicolor (153 aa),
FASTA scores: opt: 639, E(): 0, (60.8% identity in 148 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0130"
/db_xref="EnsemblGenomes-Tr:CCP42855"
/db_xref="GOA:P9WNP3"
/db_xref="InterPro:IPR002539"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR039375"
/db_xref="PDB:2C2I"
/db_xref="UniProtKB/Swiss-Prot:P9WNP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42855.1"
/translation="MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWI
HVDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPV
GSRVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA"
gene complement(158315..159658)
/gene="fadE1"
/locus_tag="Rv0131c"
CDS complement(158315..159658)
/codon_start=1
/transl_table=11
/gene="fadE1"
/locus_tag="Rv0131c"
/product="Probable acyl-CoA dehydrogenase FadE1"
/note="Rv0131c, (MTCI5.05c), len: 447 aa. Probable
fadE1,acyl-CoA dehydrogenase, similar to many e.g.
ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain
specific precursor (412 aa), FASTA scores: opt: 522, E():
1.4e-23, (30.1% identity in 425 aa overlap). Also highly
similar to MTCI5_28 from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0131c"
/db_xref="EnsemblGenomes-Tr:CCP42856"
/db_xref="GOA:P96808"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P96808"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42856.1"
/translation="MPVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLV
ALDPYDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIIGRSR
WAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSMTEPQGGSDPGLF
VTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLFIVPADTP
GIEIVRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHA
MRTIALARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWL
IDKHHDYQKVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLG
IADGATELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF"
gene complement(159700..160782)
/gene="fgd2"
/locus_tag="Rv0132c"
CDS complement(159700..160782)
/codon_start=1
/transl_table=11
/gene="fgd2"
/locus_tag="Rv0132c"
/product="Putative F420-dependent glucose-6-phosphate
dehydrogenase Fgd2"
/note="Rv0132c, (MTCI5.06c), len: 360 aa. Putative
fgd2,F420-dependent glucose-6-phosphate dehydrogenase,
highly similar to many from Mycobacteria e.g.
AAD38167|g5031431 from Mycobacterium chelonae. Also
similar to MJ1534|Q58929 N5,N10-methylene
tetrahydromethanopterin reductase from methanococcus
jannaschii (342 aa), FASTA scores: opt: 285,E(): 7.9e-11,
(28.4% identity in 292 aa overlap). And also similar to
Rv0953c, Rv0791c, etc from Mycobacterium tuberculosis.
Contains PS00013 Prokaryotic membrane lipoprotein lipid
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0132c"
/db_xref="EnsemblGenomes-Tr:CCP42857"
/db_xref="GOA:P96809"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019945"
/db_xref="InterPro:IPR031017"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/Swiss-Prot:P96809"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42857.1"
/translation="MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGV
GVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNS
TSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGN
YRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSA
TLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAAR
AADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAV
PFLHFPQDDPITAIDFYRTNVLPELR"
gene 160869..161474
/locus_tag="Rv0133"
CDS 160869..161474
/codon_start=1
/transl_table=11
/locus_tag="Rv0133"
/product="GCN5-related N-acetyltransferase"
/note="Rv0133, (MTCI5.07), len: 201 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain in C-terminal part. See
Vetting et al. 2005. Highly similar to others e.g.
PUAC_STRLP|P13249 puromycyn N-acetyltransferase (199
aa),FASTA scores: opt: 341, E(): 1.8e-16, (33.3% identity
in 201 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0133"
/db_xref="EnsemblGenomes-Tr:CCP42858"
/db_xref="GOA:P96810"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:P96810"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42858.1"
/translation="MTPQARPARRADVRELSRTMARAFYDDPVMSWLLSNDNARTARL
TRLFATIVRHQHLAGGGVEVARGAAGIGGAALWDPPDRWRESRRQQLAMTPGFLRVFG
FRTAKARAALDVMMRVHPEEPHWYLAAIGSDPTVRGQGFGQVLMRSRLDRCDAEHCPA
YLESTKPENVPYYQRFGFRVTREIALPDAGPPLWAMWREPR"
gene 161771..162673
/gene="ephF"
/locus_tag="Rv0134"
CDS 161771..162673
/codon_start=1
/transl_table=11
/gene="ephF"
/locus_tag="Rv0134"
/product="Possible epoxide hydrolase EphF (epoxide
hydratase) (arene-oxide hydratase)"
/note="Rv0134, (MTCI5.08), len: 300 aa. Possible
ephE,epoxide hydrolase (see citation below), similar to
others e.g. Q39856 epoxide hydrolase (341 aa), FASTA
scores: opt: 369, E(): 4.6e-17, (27.2% identity in 335 aa
overlap); etc. Also similar to MTCY09F9.26c from
Mycobacterium tuberculosis (29.5% identity in 346 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0134"
/db_xref="EnsemblGenomes-Tr:CCP42859"
/db_xref="GOA:P96811"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P96811"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42859.1"
/translation="MIALPALEGVEHRHVDVAEGVRIHVADAGPADGPAVMLVHGFPQ
NWWEWRDLIGPLAADGNRVLCPDLRGAGWSSAPRSRYTKTEMADDLAAVLDGLGVAKV
KLVAHDWGGPVAFIMMLRHPEKVTGFFGVNTVAPWVKRDLGMLRNMWRFWYQIPMSLP
VIGPRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAGSRWYRTFQT
REMLRWLRGEYNDARVDVPVRWLHGTGDPVITPDLLDGYAERASDFEVELVDGVGHWI
VEQRPELVLDRVRAFLAAGTEQRD"
gene complement(162644..163249)
/locus_tag="Rv0135c"
CDS complement(162644..163249)
/codon_start=1
/transl_table=11
/locus_tag="Rv0135c"
/product="Possible transcriptional regulatory protein"
/note="Rv0135c, (MTCI5.09c), len: 201 aa. Possible
transcriptional regulator, weakly similar to others e.g.
P32398|YHGD_BACSU hypothetical transcriptional regulator
from Bacillus subtilis (191 aa), FASTA scores: opt:
145,E(): 0.0012, (21.0% identity in 162 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0135c"
/db_xref="EnsemblGenomes-Tr:CCP42860"
/db_xref="GOA:P96812"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:P96812"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42860.1"
/translation="MTAVAAGALVVETDSFRLRLLDGLVASIGERGYRATTVSDIVRH
ARTSKRTFYDRFTSKEQCFLELLLADNETLGNSIRAAVDPNADWHDQIRQAVEAYVTH
IESRPAVTLSWIREFPSLGAAAYPVQRRGMEQLTSLLIELSASPGFRRANLPPLNVPL
AVILLGGLRELTALTVEDGQPIRNIVEPAVDASIALLGPRS"
gene 163366..164691
/gene="cyp138"
/locus_tag="Rv0136"
CDS 163366..164691
/codon_start=1
/transl_table=11
/gene="cyp138"
/locus_tag="Rv0136"
/product="Probable cytochrome P450 138 Cyp138"
/note="Rv0136, (MT0144, MTCI5.10), len: 441 aa. Probable
cyp138, cytochrome P450 138, similar to others e.g.
SLR0574|Q59990 from synechocystis SP. (444 aa), FASTA
scores: opt: 315, E(): 1e-13, (25.7% identity in 416 aa
overlap); etc. Also similar to MTV039_6 from Mycobacterium
tuberculosis (472 aa), FASTA score: (38.2% identity in 442
aa overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop); and PS00086 Cytochrome P450 cysteine heme-iron
ligand signature. Belongs to the cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv0136"
/db_xref="EnsemblGenomes-Tr:CCP42861"
/db_xref="GOA:P9WPM3"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002401"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPM3"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42861.1"
/translation="MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVR
RYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGD
DHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILR
AIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVID
KLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLG
WAFERLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGE
WVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAA
FANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR"
gene complement(164712..165260)
/gene="msrA"
/locus_tag="Rv0137c"
CDS complement(164712..165260)
/codon_start=1
/transl_table=11
/gene="msrA"
/locus_tag="Rv0137c"
/product="Probable peptide methionine sulfoxide reductase
MsrA (protein-methionine-S-oxide reductase) (peptide
met(O) reductase)"
/note="Rv0137c, (MTCI5.11c), len: 182 aa. Probable
msrA,peptide methionine sulfoxide reductase (See St. John
et al., 2001), equivalent to CAC32179.1|AL583926 putative
peptide methionine sulfoxide from Mycobacterium leprae
(177 aa). Highly similar to others e.g.
CAC18703.1|AL451182 putative peptide methionine sulfoxide
reductase from Streptomyces coelicolor (172 aa);
PMSR_SCHPO|Q09859 putative peptide methionine sulfoxide
reductase from Streptomyces (187 aa), FASTA scores: opt:
468, E(): 9.9e-26, (45.6% identity in 158 aa overlap);
etc. Belongs to the MsrA family."
/db_xref="EnsemblGenomes-Gn:Rv0137c"
/db_xref="EnsemblGenomes-Tr:CCP42862"
/db_xref="GOA:P9WJM5"
/db_xref="InterPro:IPR002569"
/db_xref="InterPro:IPR036509"
/db_xref="PDB:1NWA"
/db_xref="UniProtKB/Swiss-Prot:P9WJM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42862.1"
/translation="MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATY
RNHGTHAEAVEIIFDPTVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQ
QKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPG
WRLPRRTAESALRASLSPELGT"
gene 165323..165826
/locus_tag="Rv0138"
CDS 165323..165826
/codon_start=1
/transl_table=11
/locus_tag="Rv0138"
/product="Conserved hypothetical protein"
/note="Rv0138, (MTCI5.12), len: 167 aa. Conserved
hypothetical protein, showing weak similarity to
Q10827|YT10_MYCTU hypothetical 17.0 KDA protein from
Mycobacterium tuberculosis (147 aa), FASTA scores: opt:
131, E(): 0.047, (31.15% identity in 106 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0138"
/db_xref="EnsemblGenomes-Tr:CCP42863"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/TrEMBL:P96815"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42863.1"
/translation="MSASEFSRAELAAAFEKFEKTVARAAATRDWDCWVQHYTPDVEY
IEHAAGIMRGRQRVRAWIQETMTTFPGSHMVAFPSLWSVIDESTGRIICELDNPMLDP
GDGSVISATNISIITYAGNGQWCRQEDIYNPLRFLRAAMKWCRKAQELGTLDEDAARW
MRRHGGP"
gene 165827..166849
/locus_tag="Rv0139"
CDS 165827..166849
/codon_start=1
/transl_table=11
/locus_tag="Rv0139"
/product="Possible oxidoreductase"
/note="Rv0139, (MTCI5.13), len: 340 aa. Possible
oxidoreductase, similar to others e.g. O34285|HPNA HPNA
protein from Zymomonas mobilis (337 aa), FASTA scores:
opt: 507, E (): 5.8e-27, (31.1% identity in 328 aa
overlap); TRE_STRGR|P29782 dtdp-glucose 4,6-dehydratase
(328 aa),FASTA scores: opt: 254, E(): 2.6e-10, (29.0%
identity in 307 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0139"
/db_xref="EnsemblGenomes-Tr:CCP42864"
/db_xref="GOA:P96816"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P96816"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42864.1"
/translation="MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTR
SIDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNV
LDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYA
HDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAVGVDDAARA
LILAAERGRNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLR
ARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVG
KDPAAS"
gene 166910..167290
/locus_tag="Rv0140"
CDS 166910..167290
/codon_start=1
/transl_table=11
/locus_tag="Rv0140"
/product="Conserved protein"
/note="Rv0140, (MTCI5.14), len: 126 aa. Conserved
protein,similar to others e.g. P74567|D90916_48
hypothetical 20.8 KDP protein from Synechocystis sp. (180
aa), FASTA scores: opt: 229, E(): 4.7e-10, (36.1% identity
in 108 aa overlap). Also similar to Rv1056 and Rv1670 from
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0140"
/db_xref="EnsemblGenomes-Tr:CCP42865"
/db_xref="GOA:P96817"
/db_xref="InterPro:IPR007361"
/db_xref="InterPro:IPR038694"
/db_xref="UniProtKB/TrEMBL:P96817"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42865.1"
/translation="MSNRIVLEPSADHPITIEPTNRRVQVRVNGEVVADTAAALCLQE
ASYPAVQYIPLADVVQDRLIRTETSTYCPFKGEASYYSVTTDAGDIVDDVMWTYENPY
PAVAAIAGHVACYPDKAEISIFPG"
gene complement(167271..167681)
/locus_tag="Rv0141c"
CDS complement(167271..167681)
/codon_start=1
/transl_table=11
/locus_tag="Rv0141c"
/product="Unknown protein"
/note="Rv0141c, (MTCI5.15c), len: 136 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv0141c"
/db_xref="EnsemblGenomes-Tr:CCP42866"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/TrEMBL:P96818"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42866.1"
/translation="MTPFDDPQAELAWMFLQSLCEGGDLDEGFALLSNDFTYWSIVTR
TELDKKTFRRAVERRKQVFEVNIELIRCVNEGETVVVEGHCDGVSADRTRYDSPFVCI
FETRDGMIISLREYSDTQSLAEVYPVACATPGRC"
gene 167711..168637
/locus_tag="Rv0142"
CDS 167711..168637
/codon_start=1
/transl_table=11
/locus_tag="Rv0142"
/product="Conserved hypothetical protein"
/note="Rv0142, (MTCI5.16), len: 308 aa. Conserved
hypothetical protein, similar, except in N-terminus, to
AB88922.1|AL353862 hypothetical protein SCE34.20 from
Streptomyces coelicolor (326 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0142"
/db_xref="EnsemblGenomes-Tr:CCP42867"
/db_xref="GOA:P96819"
/db_xref="InterPro:IPR003265"
/db_xref="InterPro:IPR011257"
/db_xref="UniProtKB/TrEMBL:P96819"
/protein_id="CCP42867.1"
/translation="MRSIDVVVEAVVTFAGAAGFAHTLAPLRRGQQDPCFRVPGDGTI
WRTSLLPTGPVTARISRAGRDAARCVAWGSGAEEFVDMAPAMLGAADDASDFVPLHPA
VAAAHRRLPNLRLGRTGQVLEALIPAVIEQRVPGADAFRSWRLLVSKYGTQAPGPAPP
GMRVPPSAEVWRHIPSWEFHRANVDPGRARAVVGCAQRAASLERLVSLPAARAAEALT
SLPGVGVWTAAETTQRVFGDADAVSVGDYHIPKMIGWTLVGRPVDDAGMLELLEPMRP
HRHRVVRLLEASGLAREPRRGPRLPVQNIRAL"
gene complement(168704..170182)
/locus_tag="Rv0143c"
CDS complement(168704..170182)
/codon_start=1
/transl_table=11
/locus_tag="Rv0143c"
/product="Probable conserved transmembrane protein"
/note="Rv0143c, (MTCI5.17c), len: 492 aa. Probable
conserved transmembrane protein, CIC family possibly
involved in transport of chloride, similar to others and
hypothetical proteins e.g. O28857 putative chloride
channel from Archaeoglobus fulgidus (589 aa), FASTA
scores: opt: 966, E(): 0, (37.7% identity in 453 aa
overlap); YADQ_ECOLI|P37019 hypothetical 46.0 kDa protein
(436 aa),FASTA scores: opt: 452, E(): 2.4e-20, (28.0%
identity in 460 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0143c"
/db_xref="EnsemblGenomes-Tr:CCP42868"
/db_xref="GOA:P96820"
/db_xref="InterPro:IPR001807"
/db_xref="InterPro:IPR014743"
/db_xref="UniProtKB/TrEMBL:P96820"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42868.1"
/translation="MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRFGVSIRSAGYL
RKWFLLGITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGFAR
PWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGRAVLVKMVASA
LTIGSGGSGGREGPTAQISAGFCSLLTRRLNLSNEDGRTAVALGIGAGIGAIFAAPLG
GAALGASIPYRDDFDYRNLLPGFIASGTAYAVLGAFLGFDPLFGYIDAEYRFEKAWPL
LWFVVIGLIAAAVGYLYARVFHASVAITRRLPGGPVLKPAIGGLLVGLLGLPIPQILS
SGYGWAQLAADRGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVG
AAIWRLGELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVPGA
IIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA"
gene 170284..171126
/locus_tag="Rv0144"
CDS 170284..171126
/codon_start=1
/transl_table=11
/locus_tag="Rv0144"
/product="Probable transcriptional regulatory protein
(possibly TetR-family)"
/note="Rv0144, (MTCI5.18), len: 280 aa. Probable
transcriptional regulator, possibly TetR family. Has
region similar to others e.g.
Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID operon
repressor (GUS operon) from Escherichia coli strains K12
and O157:H7 (196 aa), FASTA scores: opt: 214, E():
1.1e-06,(26.0% identity in 196 aa overlap). Contains
probable helix-turn helix motif from aa 109-130 (Score
1463, +4.17 SD). Could belong to the TetR/AcrR family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv0144"
/db_xref="EnsemblGenomes-Tr:CCP42869"
/db_xref="GOA:P96821"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:P96821"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42869.1"
/translation="MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGA
KLTSSVASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQVFS
ERGYDGATFQEIAVRADLTRPAINHYFANKRVLYQEVVEQTHELVIVAGIERARREPT
LMGRLAVVVDFAMEADAQYPASTAFLATTVLESQRHPELSRTENDAVRATREFLVWAV
NDAIERGELAADVDVSSLAETLLVVLCGVGFYIGFVGSYQRMATITDSFQQLLAGTLW
RPPT"
gene 171215..172168
/locus_tag="Rv0145"
CDS 171215..172168
/codon_start=1
/transl_table=11
/locus_tag="Rv0145"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv0145, (MTCI5.19), len: 317 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), highly similar to many e.g.
CAC32172.1|AL583926 conserved hypothetical protein from
Mycobacterium leprae (310 aa); and several Mycobacterium
tuberculosis proteins e.g. Rv0726c, Rv0731c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0145"
/db_xref="EnsemblGenomes-Tr:CCP42870"
/db_xref="GOA:P9WFJ1"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42870.1"
/translation="MTELDDVSSLPSSRRTAGDTWAITESVGATALGVAAARAVETAA
TNPLIRDEFAKVLVSSAGTAWARLADADLAWLDGDQLGRRVHRVACDYQAVRTHFFDE
YFGAAVDAGVRQVVILAAGLDARAYRLNWPAGTVVYEIDQPSVLEYKAGILQSHGAVP
TARRHAVAVDLRDDWPAALIAAGFDGTQPTAWLAEGLLPYLPGDAADRLFDMVTALSA
PGSQVAVEAFTMNTKGNTQRWNRMRERLGLDIDVQALTYHEPDRSDAAQWLATHGWQV
HSVSNREEMARLGRAIPQDLVDETVRTTLLRGRLVTPAQPA"
gene 172211..173143
/locus_tag="Rv0146"
CDS 172211..173143
/codon_start=1
/transl_table=11
/locus_tag="Rv0146"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv0146, (MTCI5.20), len: 310 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), highly similar to others e.g.
AC30975.1|AL583924 conserved hypothetical protein from
Mycobacterium leprae (304 aa); and several Mycobacterium
tuberculosis proteins e.g. Rv0726c, Rv0731c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0146"
/db_xref="EnsemblGenomes-Tr:CCP42871"
/db_xref="GOA:P9WFJ3"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFJ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42871.1"
/translation="MRTHDDTWDIKTSVGATAVMVAAARAVETDRPDPLIRDPYARLL
VTNAGAGAIWEAMLDPTLVAKAAAIDAETAAIVAYLRSYQAVRTNFFDTYFASAVAAG
IRQVVILASGLDSRAYRLDWPAGTIVYEIDQPKVLSYKSTTLAENGVTPSAGRREVPA
DLRQDWPAALRDAGFDPTARTAWLAEGLLMYLPAEAQDRLFTQVGAVSVAGSRIAAET
APVHGEERRAEMRARFKKVADVLGIEQTIDVQELVYHDQDRASVADWLTDHGWRARSQ
RAPDEMRRVGRWVEGVPMADDPTAFAEFVTAERL"
gene 173238..174758
/locus_tag="Rv0147"
CDS 173238..174758
/codon_start=1
/transl_table=11
/locus_tag="Rv0147"
/product="Probable aldehyde dehydrogenase (NAD+)
dependent"
/note="Rv0147, (MTCI5.21), len: 506 aa. Probable aldehyde
dehydrogenase (NAD+) dependent, similar to others e.g.
DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric
NADP-preferring) (452 aa), FASTA scores: opt: 1291, E():
0,(43.9% identity in 453 aa overlap). Also similar to
several Mycobacterium tuberculosis aldehyde dehydrogenases
e.g. Rv0768, Rv2858c, etc. Contains PS00687 aldehyde
dehydrogenases glutamic acid active site, and PS00070
aldehyde dehydrogenases cysteine active site. Belongs to
the aldehyde dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0147"
/db_xref="EnsemblGenomes-Tr:CCP42872"
/db_xref="GOA:P96824"
/db_xref="InterPro:IPR012394"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016160"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/TrEMBL:P96824"
/inference="protein motif:PROSITE:PS00687"
/inference="protein motif:PROSITE:PS00070"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42872.1"
/translation="MSDRVKAVAPPDGRTMMTTESVARKTQKSETEAPREPAPVSDEK
QTDVAKTVARLRKTFASGRTRSVEWRKQQLRALQKLMDENEDAIAAALAEDLDRNPFE
AYLADIATTSAEAKYAAKRVRRWMRRRYLLLEVPQLPGRGWVEYEPYGTVLIIGAWNY
PFYLTLGPAVGAIAAGNAVVLKPSEIAAASAHLMTELVYRYLDTEAIAVVQGDGAVSQ
ELIAQGFDRVMFTGGTEIGRKVYEGAAPHLTPVTLELGGKSPVIVAADADVDVAAKRI
AWIKLLNAGQTCVAPDYVLADATVRDELVSKITAALTKFRSGAPQGMRIVNQRQFDRL
SGYLAAAKTDAAADGGGVVVGGDCDASNLRIQPTVVVDPDPDGPLMSNEIFGPILPVV
TVKSLDDAIRFVNSRPKPLSAYLFTKSRAVRERVIREVPAGGMMVNHLAFQVSTAKLP
FGGVGASGMGAYHGRWGFEEFSHRKSVLTKPTRPDLSSFIYPPYTERAIKVARRLF"
gene 174833..175693
/locus_tag="Rv0148"
CDS 174833..175693
/codon_start=1
/transl_table=11
/locus_tag="Rv0148"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv0148, (MTCI5.22), len: 286 aa. Probable
short-chain dehydrogenase, similar to others, in
particular Estradiol 17 beta-dehydrogenases, e.g.
DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 (735
aa), FASTA scores: opt: 952, E(): 0, (52.5% identity in
276 aa overlap). Contains PS00061 Short-chain alcohol
dehydrogenase family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv0148"
/db_xref="EnsemblGenomes-Tr:CCP42873"
/db_xref="GOA:P96825"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P96825"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42873.1"
/translation="MPGVQDRVIVVTGAGGGLGREYALTLAGEGASVVVNDLGGARDG
TGAGSAMADEVVAEIRDKGGRAVANYDSVATEDGAANIIKTALDEFGAVHGVVSNAGI
LRDGTFHKMSFENWDAVLKVHLYGGYHVLRAAWPHFREQSYGRVVVATSTSGLFGNFG
QTNYGAAKLGLVGLINTLALEGAKYNIHANALAPIAATRMTQDILPPEVLEKLTPEFV
APVVAYLCTEECADNASVYVVGGGKVQRVALFGNDGANFDKPPSVQDVAARWAEITDL
SGAKIAGFKL"
gene 175700..176668
/locus_tag="Rv0149"
CDS 175700..176668
/codon_start=1
/transl_table=11
/locus_tag="Rv0149"
/product="Possible quinone oxidoreductase (NADPH:quinone
oxidoreductase) (zeta-crystallin)"
/note="Rv0149, (MTCI5.23), len: 322 aa. Possible quinone
oxidoreductase, similar to others oxidoreductases e.g.
Q08257 quinone oxidoreductase (329 aa), FASTA scores: opt:
397, E(): 3.2e-18, (28.4% identity in 328 aa overlap);
SCHCOADH_4 from Streptomyces coelicolor. Also similar to
many proteins from Mycobacterium tuberculosis. Contains
PS01162 Quinone oxidoreductase / zeta-crystallin
signature. Belongs to the zinc-containing alcohol
dehydrogenase family, quinone oxidoreductase subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0149"
/db_xref="EnsemblGenomes-Tr:CCP42874"
/db_xref="GOA:P96826"
/db_xref="InterPro:IPR002364"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P96826"
/inference="protein motif:PROSITE:PS01162"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42874.1"
/translation="MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDL
LLTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVA
NVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAK
AMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGP
TFDDALGVLAIDGKLLLIGFAAGAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAAL
FAWGLNQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVLEP"
gene complement(176665..176952)
/locus_tag="Rv0150c"
CDS complement(176665..176952)
/codon_start=1
/transl_table=11
/locus_tag="Rv0150c"
/product="Conserved hypothetical protein"
/note="Rv0150c, (MTCI5.24c), len: 95 aa. Conserved
hypothetical protein, showing some similarity with
C-terminus of O53949|Rv1800|MTV049.22 PPE-family protein
from Mycobacterium tuberculosis (655 aa), FASTA score:
(36.5% identity in 104 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0150c"
/db_xref="EnsemblGenomes-Tr:CCP42875"
/db_xref="UniProtKB/TrEMBL:P96827"
/protein_id="CCP42875.1"
/translation="MLTLPDDRAPTGLPDPGIEALAHTKIASTISTVVADGYAVVLST
ADIANSLLANAIGYPIAASVALVTPAAGANSSCWPADPSQHHRIAESRACA"
gene complement(177543..179309)
/gene="PE1"
/locus_tag="Rv0151c"
CDS complement(177543..179309)
/codon_start=1
/transl_table=11
/gene="PE1"
/locus_tag="Rv0151c"
/product="PE family protein PE1"
/note="Rv0151c, (MTCI5.25c), len: 588 aa. PE1, Member of
the Mycobacterium tuberculosis PE family (see citation
below), with N-terminal region similar to others e.g.
MTV032_2 PE_PGRS family from Mycobacterium tuberculosis
(468 aa), FASTA scores: opt: 1125, E(): 0, (46.3% identity
in 456 aa overlap); MTCY493_24 from Mycobacterium
tuberculosis FASTA score: (42.5% identity in 558 aa
overlap). Also similar to upstream ORF MTCI5.26c FASTA
score: (54.7% identity in 464 aa overlap). Also shows
similarity to C-terminal part of some PPE family proteins
e.g. MTV049_21 from Mycobacterium tuberculosis FASTA
score: (41.5% identity in 591 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0151c"
/db_xref="EnsemblGenomes-Tr:CCP42876"
/db_xref="GOA:Q79G06"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:Q79G06"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42876.1"
/translation="MAPFGFTPKARHNRGVALRSTYRLDGWVMGPVDKEGWGLSYVFA
QPSVLAAAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQFQA
ISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEATAGLFKPTSPPVLPPMFNQN
TAIIMGGTGSPIPTPSYVNAITTLFIDPVVSNPVVKALVTPEELYPITGVKSLPFQTS
VQLGLQILDGAIWEQINAGNHVTVFGYSQSAVIASLEMQHLISLGPNAPSPSQLNFIL
IGNEMNPNGGILARIPGLNVTTLGLPFYGATPDNPYPTTTYTLEYDGFADFPRYPLNV
LSDINAVFGILTVHTTYADLTPAQIASATQLPTQGTTSNTYYIIETEHLPLLAPLRAI
PVIGPPLAALVEPNLEVIVNLGYGDPRFGYSTSPANVPTPFGLFPDVPASVVADALVA
GTQQGVNDFMVELPAALNTLPQTPMPAFPPYVPTLLPPPPPPQPATLINIADTFASVV
STGYSILLPTADLGLAFVTILPAYDLTLFVNQLAAGNLRAAIELPLAATIGLAALGGM
IEFIAIVVTLADITQQLQSFSI"
gene complement(179319..180896)
/gene="PE2"
/locus_tag="Rv0152c"
CDS complement(179319..180896)
/codon_start=1
/transl_table=11
/gene="PE2"
/locus_tag="Rv0152c"
/product="PE family protein PE2"
/note="Rv0152c, (MTCI5.26c), len: 525 aa. PE2, Member of
the Mycobacterium tuberculosis PE family (see citation
below), similar to ORF downstream Z92770|MTCI5_25 (588
aa),FASTA scores: opt: 1492, E(): 0, (54.7% identity in
464 aa overlap); and to many other PE family type members.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0152c"
/db_xref="EnsemblGenomes-Tr:CCP42877"
/db_xref="GOA:Q79G05"
/db_xref="InterPro:IPR013228"
/db_xref="UniProtKB/TrEMBL:Q79G05"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42877.1"
/translation="MRCRPPSRNRSAHTARNTRPCSLKSRRFTVRFHQTLAAAANSYA
DAEAAIASTRQNQLAVPAAAPTPAAAAMIPPFPANLTTLFFGPTGIPLPPPSMLTPPI
RCRSVRRALQAVFTPEELYPLTGVRSLVLNTSVEEGLTILHDAIMVELATTGNAVTVF
GWSQSAIIASLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDL
TFYGATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHTKYLDLTPAQ
VEGATKLPTSPGYTGVTDYYIIRTENRPLLQPLRAVPVIGDPLADLIQPNLKVIVNLG
YGDPNYGYSTSYADVRTPFGLWPNVPPQVIADALAAGTQEGILDFTADLQALSAQPLT
LPQIQLPQPADLVAAVAAAPTPAEVVNTLARIISTNYAVLLPTVDIALALVTTLPLYT
TQLFVRQLAAGNLINAIGYPLAATVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLT
DSRRHRRPPTTVYRPRQ"
gene complement(181155..181985)
/gene="ptbB"
/gene_synonym="MPtpB"
/locus_tag="Rv0153c"
CDS complement(181155..181985)
/codon_start=1
/transl_table=11
/gene="ptbB"
/gene_synonym="MPtpB"
/locus_tag="Rv0153c"
/product="Phosphotyrosine protein phosphatase PTPB
(protein-tyrosine-phosphatase) (PTPase)"
/note="Rv0153c, (MTCI5.27c), len: 276 aa. PtbB (alternate
gene name: MPtpB), protein-tyrosine-phosphatase (see
citation below), showing some similarity to several
protein-tyrosine phosphatases, polyketide synthase and
aminotransferase e.g. Q05918|IPHP_NOSCO|IPH
protein-tyrosine-phosphatase precursor from Nostoc commune
(294 aa), FASTA scores: opt: 150, E(): 0.0096, (26.8%
identity in 269 aa overlap); etc. Supposedly a secreted
protein. Potent and selective inhibitor is an isoxazole
compound (See Seollner et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0153c"
/db_xref="EnsemblGenomes-Tr:CCP42878"
/db_xref="GOA:I6WXK4"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR026893"
/db_xref="InterPro:IPR029021"
/db_xref="UniProtKB/TrEMBL:I6WXK4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42878.1"
/translation="MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATL
RRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLL
TNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHC
FAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPE
VVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
"
gene complement(181987..183198)
/gene="fadE2"
/locus_tag="Rv0154c"
CDS complement(181987..183198)
/codon_start=1
/transl_table=11
/gene="fadE2"
/locus_tag="Rv0154c"
/product="Probable acyl-CoA dehydrogenase FadE2"
/note="Rv0154c, (MTCI5.28c), len: 403 aa. Probable
fadE2,acyl-CoA dehydrogenase, similar to many e.g.
C-terminal region of O01590 acyl-CoA dehydrogenase (974
aa), FASTA scores: opt: 1150, E(): 0, (50.0% identity in
402 aa overlap); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase
(short-chain) (383 aa), FASTA score: (35.0% identity in
306 aa overlap). Could belong to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0154c"
/db_xref="EnsemblGenomes-Tr:CCP42879"
/db_xref="GOA:P96831"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P96831"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42879.1"
/translation="MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRAAGPADHTAPPI
IEELKTKAKDRGLWNLFLSAESGLTNLEYAPLAEMTGWSMEIAPEALNCAAPDTGNME
ILHMFGTEQQRAQWLRPLLDGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGR
KWWTSGAADPRCKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRH
GHCEIDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALALMVNRV
RNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQHGNKEARHLVAMIKA
VAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGWHRAMRIFDGPDEVHLRSIARAELS
REKSTFAAAVT"
gene 183622..184722
/gene="pntAa"
/locus_tag="Rv0155"
CDS 183622..184722
/codon_start=1
/transl_table=11
/gene="pntAa"
/locus_tag="Rv0155"
/product="Probable NAD(P) transhydrogenase (subunit alpha)
PntAa [first part; catalytic part] (pyridine nucleotide
transhydrogenase subunit alpha) (nicotinamide nucleotide
transhydrogenase subunit alpha)"
/note="Rv0155, (MTCI5.29), len: 366 aa. Probable
pntAa,first part of NAD(P) transhydrogenase subunit
alpha,similar to N-terminus of others e.g.
PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase
subunit alpha from Escherichia coli strain K12 (510
aa),FASTA scores: opt: 921, E(): 0, (42.1% identity in 361
aa overlap); proton-translocating nicotinamide nucleotide
transhydrogenase subunit PNTAA."
/db_xref="EnsemblGenomes-Gn:Rv0155"
/db_xref="EnsemblGenomes-Tr:CCP42880"
/db_xref="GOA:P96832"
/db_xref="InterPro:IPR007698"
/db_xref="InterPro:IPR007886"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P96832"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42880.1"
/translation="MTDPQTQSTRVGVVAESGPDERRVALVPKAVASLVNRGVAVVVE
AGAGERALLPDELYTAVGASIGDAWAADVVVKVAPPTAAEVGRLRGGQTLIGFLAPRN
ADNSIGALTQAGVQAFALEAIPRISRAQVMDALSSQANVSGYKAVLLAASESTRFFPM
LTTAAGTVKPATVLVLGVGVAGLQALATAKRLGARTTGYDVRPEVADQVRSVGAQWLD
LGISASGEGGYARELTDDERAQQQKALEEAISGFDVVITTALVPGRPAPTLVTAAAVE
AMKPGSVVVDLAGETGGNCELTEPGRTVVKHDVTIAAPLNLPATMPEHASELYSKNIT
ALLDLLIKDGRLAPDFDDEVIAQSCVTRGKDS"
gene 184723..185055
/gene="pntAb"
/locus_tag="Rv0156"
CDS 184723..185055
/codon_start=1
/transl_table=11
/gene="pntAb"
/locus_tag="Rv0156"
/product="Probable NAD(P) transhydrogenase (subunit alpha)
PntAb [second part; integral membrane protein] (pyridine
nucleotide transhydrogenase subunit alpha) (nicotinamide
nucleotide transhydrogenase subunit alpha)"
/note="Rv0156, (MTCI5.30), len: 110 aa. Probable
pntAb,second part of NAD(P) transhydrogenase subunit
alpha,integral membrane protein, similar to C-terminus of
others e.g. Q59764 nicotinamide nucleotide
transhydrogenase subunit PNTAB (139 aa), FASTA scores:
opt: 247, E(): 1.9e-11, (45.5% identity in 88 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0156"
/db_xref="EnsemblGenomes-Tr:CCP42881"
/db_xref="GOA:P96833"
/db_xref="InterPro:IPR024605"
/db_xref="UniProtKB/TrEMBL:P96833"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42881.1"
/translation="MYNELLENLAILVLSGFVGFAVISKVPNTLHTPLMSGTNAIHGI
VVLGALVVFGEIEHPSLVLQVILFVAVVFGTLNVIGGFIVTDRMLGMFKAKKPAVPAK
PDRDEALR"
gene 185052..186479
/gene="pntB"
/locus_tag="Rv0157"
CDS 185052..186479
/codon_start=1
/transl_table=11
/gene="pntB"
/locus_tag="Rv0157"
/product="Probable NAD(P) transhydrogenase (subunit beta)
PntB [integral membrane protein] (pyridine nucleotide
transhydrogenase subunit beta) (nicotinamide nucleotide
transhydrogenase subunit beta)"
/note="Rv0157, (MTCI5.31), len: 475 aa. Probable
pntB,pyridine nucleotide transhydrogenase (nicotinamide
nucleotide transhydrogenase) subunit beta, integral
membrane protein, similar to others e.g. Q59763
proton-translocating nicotinamide nucleotide
transhydrogenase subunit beta from hodospirillum rubrum
(464 aa), FASTA scores: opt: 1344, E(): 0, (46.4% identity
in 472 aa overlap);
P07002|PNTB_ECOLI|P76890|PNTB|B1602|Z2597|ECS2308 NAD(P)
transhydrogenase subunit beta from Escherichia coli
strains K12 and O157:H7 (462 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0157"
/db_xref="EnsemblGenomes-Tr:CCP42882"
/db_xref="GOA:P96834"
/db_xref="InterPro:IPR012136"
/db_xref="InterPro:IPR029035"
/db_xref="InterPro:IPR034300"
/db_xref="UniProtKB/TrEMBL:P96834"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42882.1"
/translation="MNLHYLVEILYIISFSLFIYGLMGLTGPKTAVRGNLIAAAGMTI
AVAATLVMIRHTSQWPLIIAGLVVGVVLGVPPARLTKMTAMPQLVAFFNGVGGGTVAL
IALSEFIDTTGFSAFQHGESPTVHIVVASLFAAIIGSISFWGSIVAFGKLQEIISGRP
IGLGKAQQPINLLLLAVAVAAAVVIGLHAHPGSGGVALWWMIGLLVAAGVLGLMVVLP
IGGADMPVVISMLNAMTGLSAAAAGLALNNTAMIVAGMIVGASGSILTNLMAKAMNRS
IPAIVAGGFGGGGVAPSGGGDDKHVKATSAADAAIQMAYANQVIVVPGYGLAVAQAQH
AVKDLATLLEDRGVPVKYAIHPVAGRMPGHMNVLLAEAEVDYDAMKDMDDINDEFART
DVTIVIGANDVTNPAARNETSSPIYGMPILNVDKSRSVIVLKRSMNSGFAGIDNPLFY
ADGTTMLFGDAKKSVTEVSEELKAL"
gene complement(186495..186623)
/locus_tag="Rv0157A"
CDS complement(186495..186623)
/codon_start=1
/transl_table=11
/locus_tag="Rv0157A"
/product="Conserved protein"
/note="Rv0157A, len: 42 aa. Conserved protein, showing
similarity to C-terminal part (aa 186-220) of
O53976|Rv1975|MTV051.13 conserved hypothetical protein
from Mycobacterium tuberculosis (221 aa), FASTA scores:
opt: 173, E(): 3e-06, (62.5% identity in 40 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0157A"
/db_xref="EnsemblGenomes-Tr:CCP42883"
/db_xref="UniProtKB/TrEMBL:I6WXK8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42883.1"
/translation="MMDPSPDYDVSDEIEFFFRYLTWGLRGVETGDGYPPPAYPPV"
gene 186785..187429
/locus_tag="Rv0158"
CDS 186785..187429
/codon_start=1
/transl_table=11
/locus_tag="Rv0158"
/product="Probable transcriptional regulatory protein
(possibly TetR-family)"
/note="Rv0158, (MTV032.01), len: 214 aa. Probable
transcriptional regulator, possibly TetR family, showing
weak similarity to various transcriptional activators and
repressors e.g. P32398|YIXD_BACSU|YHGD hypothetical
transcriptional regulatory protein from Bacillus subtilis
(191 aa), FASTA scores: opt:172, E(): 2.4e-05, (23.0%
identity in 191 aa overlap). Contains helix-turn-helix
motif at aa 32-53 (Score 1296, +3.60 SD). Could belong to
the TetR/AcrR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv0158"
/db_xref="EnsemblGenomes-Tr:CCP42884"
/db_xref="GOA:O53641"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041490"
/db_xref="UniProtKB/TrEMBL:O53641"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42884.1"
/translation="MPSDTSPNGLSRREELLAVATKLFAARGYHGTRMDDVADVIGLN
KATVYHYYASKSLILFDIYRQAAEGTLAAVHDDPSWTAREALYQYTVRLLTAIASNPE
RAAVYFQEQPYITEWFTSEQVAEVREKEQQVYEHVHGLIDRGIASGEFYECDSHVVAL
GYIGMTLGSYRWLRPSGRRTAKEIAAEFSTALLRGLIRDESIRNQSPLGTRKET"
gene complement(187433..188839)
/gene="PE3"
/locus_tag="Rv0159c"
CDS complement(187433..188839)
/codon_start=1
/transl_table=11
/gene="PE3"
/locus_tag="Rv0159c"
/product="PE family protein PE3"
/note="Rv0159c, (MTV032.02c), len: 468 aa. PE3, Member of
the Mycobacterium tuberculosis PE family (see citation
below), similar to many other PE proteins e.g. O06828 from
Mycobacterium tuberculosis (528 aa), FASTA scores: opt:
1163, E(): 0, (45.8% identity in 467 aa overlap). Also
highly similar to upstream MTV032_3, and to
MTCI5_25,MTCI5_26, MTV049_ 21, MTCY1A10_26, etc."
/db_xref="EnsemblGenomes-Gn:Rv0159c"
/db_xref="EnsemblGenomes-Tr:CCP42885"
/db_xref="GOA:Q79G04"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:Q79G04"
/protein_id="CCP42885.1"
/translation="MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAA
DEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTA
GSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTP
EQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMA
LPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMY
TGQYDGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTH
YYMFLTQDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPI
NPIAVASALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTEL
SVLSGALGSVARLIPPIA"
gene complement(188931..190439)
/gene="PE4"
/locus_tag="Rv0160c"
CDS complement(188931..190439)
/codon_start=1
/transl_table=11
/gene="PE4"
/locus_tag="Rv0160c"
/product="PE family protein PE4"
/note="Rv0160c, (MTV032.03c), len: 502 aa. PE4, Member of
the Mycobacterium tuberculosis PE family (see citation
below), similar to many other PE proteins e.g.
Z92770|MTCI5_26c from Mycobacterium tuberculosis (525
aa),FASTA scores: opt: 816, E(): 0, (41.4% identity in 367
aa overlap); C-terminal region of O06801|RV1768|MTCY28.34
from Mycobacterium tuberculosis (618 aa), FASTA scores:
opt: 417, E(): 6.7e-18, (53.5% identity in 142 aa
overlap). Also highly similar to downstream ORF MTV032_2."
/db_xref="EnsemblGenomes-Gn:Rv0160c"
/db_xref="EnsemblGenomes-Tr:CCP42886"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:L7N661"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42886.1"
/translation="MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAG
DEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAEAANAARVSHAL
DTINAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPITALIMGGTNNPLPDPEYVT
DINKAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLAL
DNKVVAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYI
PFLDVPFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPE
LMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRV
LVDLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYLIKGSLQAPYGAIVEIGVEAGL
IGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILHLIPPPVFT"
gene 190607..191956
/locus_tag="Rv0161"
CDS 190607..191956
/codon_start=1
/transl_table=11
/locus_tag="Rv0161"
/product="Possible oxidoreductase"
/note="Rv0161, (MTCI28.01, MTV032.04), len: 449 aa.
Possible oxidoreductase, similar to hypothetical proteins
and various oxidoreductases e.g. AIP2_YEAST|P46681 actin
interacting protein 2 (530 aa), FASTA scores: opt: 356, E
(): 0, (33.3% identity in 357 aa overlap);
DLD1_YEAST|P32891 d-lactate dehydrogenase (cytochrome)
(587 aa), FASTA scores: opt: 311, E(): 2.5e-20, (27.9%
identity in 366 aa overlap). Also similar to other
Mycobacteria proteins e.g. MTCY339.30c from Mycobacterium
tuberculosis FASTA score: (29.4% identity in 357 aa
overlap); MLCL622.30c from Mycobacterium tuberculosis (449
aa)."
/db_xref="EnsemblGenomes-Gn:Rv0161"
/db_xref="EnsemblGenomes-Tr:CCP42887"
/db_xref="GOA:O07406"
/db_xref="InterPro:IPR004113"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016164"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016167"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR016171"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:O07406"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42887.1"
/translation="MLTSLVSAVGSHHVTTDPDVLAGRSVDHTGRYRGRASALVRPGS
AEEVAEVLRVCRDAGAYVTVQGGRTSLVAGTVPEHDDVLLSTERLCVVSDVDTVERRI
EIGAGVTLAAVQHAASTAGLVFGVDLSARDTATVGGMASTNAGGLRTVRYGNMGEQVV
GLDVALPDGTVLRRHSRVRRDNTGYDLPALFVGAEGTLGVITALDLRLHPTPSHRVTA
VCGFAELAALVDAGRMFRDVEGIAALELIDGRAAALTREHLGVRPPVEADWLLLVELA
ADHDQTDRLADLLGGARMCGEPAVGVDAAAQQRLWRTRESLAEVLGVYGPPLKFDVSL
PLSAISGFARDAVALVHRHVPDSPEALPLLFGHIGEGNLHLNVLRCPPDREPALYAKM
MGLIAECGGNVSSEHGVGSRKRAYLGMSRQANDVAAMRRVKAALDPTGYLNAAVLFD"
gene complement(191984..193135)
/gene="adhE1"
/locus_tag="Rv0162c"
CDS complement(191984..193135)
/codon_start=1
/transl_table=11
/gene="adhE1"
/locus_tag="Rv0162c"
/product="Probable zinc-type alcohol dehydrogenase (E
subunit) AdhE1"
/note="Rv0162c, (MTCI28.02c), len: 383 aa. Probable
adhE1,zinc-type alcohol dehydrogenase, similar to others
e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha chain
(374 aa), FASTA scores: opt: 619, E(): 0, (34.7% identity
in 363 aa overlap). Also similar to other alcohol
dehydrogenases from Mycobacterium tuberculosis e.g.
MTCY369.06c FASTA score: (34.0% identity in 365 aa
overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa
overlap). Contains PS00059 Zinc-containing alcohol
dehydrogenases signature. Belongs to the zinc-containing
alcohol dehydrogenase family,class-I subfamily. Cofactor:
zinc."
/db_xref="EnsemblGenomes-Gn:Rv0162c"
/db_xref="EnsemblGenomes-Tr:CCP42888"
/db_xref="GOA:L7N6B3"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:L7N6B3"
/inference="protein motif:PROSITE:PS00059"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42888.1"
/translation="MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDP
PDRGEVLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAVGQR
VVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVSGF
ATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQSVAVVGLGGVG
MAAVLTALTYTDVRVVAVDQLPEKLSAAKALGAHEIYTPQQATAGGVKAAVVVEAVGH
PAALHTAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIP
RFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL"
gene 193117..193572
/locus_tag="Rv0163"
CDS 193117..193572
/codon_start=1
/transl_table=11
/locus_tag="Rv0163"
/product="Conserved protein"
/note="Rv0163, (MTCI28.03), len: 151 aa. Conserved
protein,similar to others e.g. Q44017 hypothetical 16.6
KDA protein in GBD 5'region (ORF6)from Alcaligenes
eutrophus (145 aa),FASTA scores: opt: 155, E(): 0.0002,
(26.6% identity in 139 aa overlap). Also weak similarity
with MTV008.31c|Rv2475c|B70867 from Mycobacterium
tuberculosis (138 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0163"
/db_xref="EnsemblGenomes-Tr:CCP42889"
/db_xref="GOA:O07408"
/db_xref="InterPro:IPR006683"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:O07408"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42889.1"
/translation="MAALPAPEKLLRSDFPVLWPVGTRWADNDMFGHLNNAVYYQLFD
TAINAWINTSTGVDPLAMPVLGIVAESGCRYFSELRFPESLMVGLAVTRLGRSSVTYR
LGVFKEPDDAGVITALGHWVHVYVDRTSRRPVPIPEAIRSLLSTACVSG"
gene 193626..194111
/gene="TB18.5"
/locus_tag="Rv0164"
CDS 193626..194111
/codon_start=1
/transl_table=11
/gene="TB18.5"
/locus_tag="Rv0164"
/product="Conserved protein TB18.5"
/note="Rv0164, (MTCI28.04), len: 161 aa. TB18.5, conserved
protein, equivalent to CAB08818.1|Z95398 hypothetical
protein from Mycobacterium leprae (156 aa) FASTA scores:
opt: 762, E(): 0, (76.3% identity in 152 aa overlap). Some
similarity to Rv2185c, Rv0854, Rv0857 from Mycobacterium
tuberculosis. Alternative start codon has been suggested.
3' part corrected since first submission (-24 aa). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0164"
/db_xref="EnsemblGenomes-Tr:CCP42890"
/db_xref="InterPro:IPR005031"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:L7N657"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42890.1"
/translation="MTAISCSPRPRYASRMPVLSKTVEVTADAASIMAIVADIERYPE
WNEGVKGAWVLARYDDGRPSQVRLDTAVQGIEGTYIHAVYYPGENQIQTVMQQGELFA
KQEQLFSVVATGAASLLTVDMDVQVTMPVPEPMVKMLLNNVLEHLAENLKQRAEQLAA
S"
gene complement(194144..194815)
/gene="mce1R"
/locus_tag="Rv0165c"
CDS complement(194144..194815)
/codon_start=1
/transl_table=11
/gene="mce1R"
/locus_tag="Rv0165c"
/product="Probable transcriptional regulatory protein
Mce1R (probably GntR-family)"
/note="Rv0165c, (MTCI28.05c), len: 223 aa. Probable
mce1R,transcriptional regulator, GntR family (See Casali
et al.,2006), showing some similarity to several e.g.
NTRA_CHELE|P54988 nta operon transcriptional regulator
(231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0%
identity in 125 aa overlap); P46833|GNTR_BACLI gluconate
operon transcriptional repressor from Bacillus
licheniformis (243 aa); GNTR_BACSU gluconate operon
repressor from Bacillus subtilis (243 aa). Also similar to
Rv0043c from Mycobacterium tuberculosis. Seems to belong
to the GntR family of transcriptional regulators. Start
changed since first submission (-41 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0165c"
/db_xref="EnsemblGenomes-Tr:CCP42891"
/db_xref="GOA:Q79G00"
/db_xref="InterPro:IPR000524"
/db_xref="InterPro:IPR008920"
/db_xref="InterPro:IPR011711"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:Q79G00"
/protein_id="CCP42891.1"
/translation="MNAPLSAKPRSQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIR
LDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATIAQ
ELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLA
WFLLNAARYMGAGVRGRPAMGRGRGEQSSAADRRAAPPRHSRRNRAHRLAVHRWGTQA
DGGPG"
gene 194993..196657
/gene="fadD5"
/locus_tag="Rv0166"
CDS 194993..196657
/codon_start=1
/transl_table=11
/gene="fadD5"
/locus_tag="Rv0166"
/product="Probable fatty-acid-CoA ligase FadD5
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0166, (MTCI28.06), len: 554 aa. Probable
fadD5,fatty-acid-CoA synthetase, similar to many eg
LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561
aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in
534 aa overlap). Also similar to many other fatty-acid-CoA
ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c
FASTA score: (35.3% identity in 487 aa overlap),
MTV013_10,MTY25D10_30, etc. Contains PS00455 putative
AMP-binding domain signature."
/db_xref="EnsemblGenomes-Gn:Rv0166"
/db_xref="EnsemblGenomes-Tr:CCP42892"
/db_xref="GOA:O07411"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O07411"
/inference="protein motif:PROSITE:PS00455"
/protein_id="CCP42892.1"
/translation="MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPA
LRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAANMIGAI
AVPLNFRLTPTEIAVLVEDCVAHVMLTEAALAPVAIGVRNIQPLLSVIVVAGGSSQDS
VFGYEDLLNEAGDVHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYT
SGANINSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVT
GIFLVPAQWQAVCTEQQARPRDLRLRVLSWGAAPAPDALLRQMSATFPETQILAAFGQ
TEMSPVTCMLLGEDAIAKRGSVGRVIPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMS
CYWNNPEATAEAFAGGWFHSGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVL
ASHPDIAEVAVIGRADEKWGEVPIAVAAVTNDDLRIEDLGEFLTDRLARYKHPKALEI
VDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL"
gene 196861..197658
/gene="yrbE1A"
/locus_tag="Rv0167"
CDS 196861..197658
/codon_start=1
/transl_table=11
/gene="yrbE1A"
/locus_tag="Rv0167"
/product="Conserved integral membrane protein YrbE1A"
/note="Rv0167, (MTCI28.07), len: 265 aa. YrbE1A, unknown
integral membrane protein, part of mce1 operon and member
of YrbE family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa);
O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly
similar or similar to conserved hypothetical integral
membrane proteins of yrbEA type, e.g.
NP_302654.1|NC_002677 conserved membrane protein from
Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086
hypothetical protein from Haemophilus influenzae (261 aa),
FASTA scores: opt: 328,E(): 1.8e-15, (26.6% identity in
244 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0167"
/db_xref="EnsemblGenomes-Tr:CCP42893"
/db_xref="GOA:O07412"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:O07412"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42893.1"
/translation="MTTSTTLGGYVRDQLQTPLTLVGGFFRMCVLTGKALFRWPFQWR
EFILQCWFIMRVGFLPTIMVSIPLTVLLIFTLNILLAQFGAADISGSGAAIGAVTQLG
PLTTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVLASMLVATLL
NGLVITVGLVGGFLFGVYLQNVSGGAYLATLTLITGLPEVVIATIKAATFGLIAGLVG
CYRGLTVRGGSKGLGTAVNETVVLCVIALFAVNVILTTIGVRFGTGR"
gene 197660..198529
/gene="yrbE1B"
/locus_tag="Rv0168"
CDS 197660..198529
/codon_start=1
/transl_table=11
/gene="yrbE1B"
/locus_tag="Rv0168"
/product="Conserved integral membrane protein YrbE1B"
/note="Rv0168, (MTCI28.08), len: 289 aa. YrbE1B, unknown
integral membrane protein, part of mce1 operon and member
of YrbE family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa);
O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly
similar to conserved hypothetical integral membrane
proteins of the yrbEB type, e.g. NP_302655.1|NC_002677
conserved membrane protein from Mycobacterium leprae (289
aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from
Haemophilus influenzae (261 aa), FASTA scores: opt:
223,E(): 7.6e-07, (23.7% identity in 257 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv0168"
/db_xref="EnsemblGenomes-Tr:CCP42894"
/db_xref="GOA:L0T2Q9"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:L0T2Q9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42894.1"
/translation="MSTAAVLRARFPRAVANLRQYGGAAARGLDEAGQLTWFALTSIG
QIAHALRYYRKETLRLIAQIGMGTGAMAVVGGTVAIVGFVTLSGSSLVAIQGFASLGN
IGVEAFTGFFAALINVRIAGPVVTGVALAATVGAGATAELGAMRISEEIDALEVMGIK
SISFLASTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFQTFLRPD
DVFWSFLEALIITAIVMVSHCYYGYAAGGGPVGVGEAVGRSMRFSLVSVQVVVLFAAL
ALYGVDPNFNLTV"
gene 198534..199898
/gene="mce1A"
/gene_synonym="mce1"
/locus_tag="Rv0169"
CDS 198534..199898
/codon_start=1
/transl_table=11
/gene="mce1A"
/gene_synonym="mce1"
/locus_tag="Rv0169"
/product="Mce-family protein Mce1A"
/note="Rv0169, (MTCI28.09), len: 454 aa. Mce1A; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins
O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa);
O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also
highly similar to others e.g.
AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry
protein from Mycobacterium bovis BCG (454 aa);
NP_302656.1|NC_002677 putative cell invasion protein from
Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene
product from Mycobacterium avium (88 aa) (similarity on
C-terminus); CAC12798.1|AL445327 putative secreted protein
from Streptomyces coelicolor (418 aa); etc. Note that
equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901
Mcep protein from Mycobacterium tuberculosis (432 aa).
Contains a very hydrophobic region around residues 20-35.
Note that previously known as mce1. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004). Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0169"
/db_xref="EnsemblGenomes-Tr:CCP42895"
/db_xref="GOA:Q79FZ9"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="InterPro:IPR024516"
/db_xref="UniProtKB/TrEMBL:Q79FZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42895.1"
/translation="MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPK
TQLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIHLI
PANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEINTLFQTLTSIA
EKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDLNSRMPQSRHDIQQLAALG
DVYADAAPDLFDFLDSSVTTARTINAQQAELDSALLAAAGFGNTTADVFDRGGPYLQR
GVADLVPTATLLDTYSPELFCTIRNFYDADPLAKAASGGGNGYSLRTNSEILSGIGIS
LLSPLALATNGAAIGIGLVAGLIAPPLAVAANLAGALPGIVGGAPNPYTYPENLPRVN
ARGGPGGAPGCWQPITRDLWPAPYLVMDTGASLAPYNHMEVGSPYAVEYVWGRQVGDN
TINP"
gene 199895..200935
/gene="mce1B"
/gene_synonym="mceD"
/locus_tag="Rv0170"
CDS 199895..200935
/codon_start=1
/transl_table=11
/gene="mce1B"
/gene_synonym="mceD"
/locus_tag="Rv0170"
/product="Mce-family protein Mce1B"
/note="Rv0170, (MTCI28.10), len: 346 aa. Mce1B (alternate
gene name: mceD); belongs to 24-membered Mycobacterium
tuberculosis Mce protein family (see citations
below),highly similar to Mycobacterium tuberculosis
proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa);
O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly
similar to others e.g. NP_302657.1|NC_002677 putative
secreted protein from Mycobacterium leprae (346 aa);
CAC12797.1|AL445327 putative secreted protein from
Streptomyces coelicolor (354 aa); etc. Contains
hydrophobic region in N-terminal 30 residues. In
Escherichia coli,N-terminal part is functional and directs
export of a leaderless beta-lactamase into the periplasm
(see Chubb et al., 1998). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0170"
/db_xref="EnsemblGenomes-Tr:CCP42896"
/db_xref="GOA:O07414"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O07414"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42896.1"
/translation="MKITGTVVKLGIVSVVLLFFTVMIIVIFGQMRFDRTNGYTAEFS
NVSGLRQGQFVRASGVEIGKVKALHLVDGGRRVRVEFNIDRSVPLYQSTTAQIRYSDL
IGNRYVELKRGEGKGANDLLPPGGLIPLSRTSPALDLDALIGGFKPVFRALDPAKVNN
IANALITVFQGQGGTINDILDQTAQLTSQIAERDQAIGEVVKNLNIVLDTTVKHRKEF
DETVNNLENLITGLRNHSDQLAGGLAHISNGAGTVADLLAENRTLVRKAVSYLDAIQQ
PVIDQRVELDDLLHKTPTALTALGRANGTYGDFQNFYLCDLQIKWNGFQAGGPVRTVK
LFSQPTGRCTPQ"
gene 200932..202479
/gene="mce1C"
/locus_tag="Rv0171"
CDS 200932..202479
/codon_start=1
/transl_table=11
/gene="mce1C"
/locus_tag="Rv0171"
/product="Mce-family protein Mce1C"
/note="Rv0171, (MTCI28.11), len: 515 aa. Mce1C; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481
aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also
highly similar to others e.g. NP_302658.1|NC_002677
putative secreted protein from Mycobacterium leprae (519
aa); CAC12796.1|AL445327 putative secreted protein from
Streptomyces coelicolor (351 aa); etc. Weakly similar to
downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA
score: (24.6% identity in 552 aa overlap). Contains
possible signal sequence and highly proline-rich
C-terminus. Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0171"
/db_xref="EnsemblGenomes-Tr:CCP42897"
/db_xref="GOA:O07415"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O07415"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42897.1"
/translation="MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYG
QFTDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNTIGTESRLAIRTDTI
LGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKAASGWDIETVKRSLNV
LSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITHLLAQANQVASILGDRSEQVDRLL
VNAKTLIAAFNERGRAVDALLGNISAFSAQVQNLINDNPNLNHVLEQLRILTDLLVDR
KEDLAETLTILGRFSASFGETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPED
FWRSAGLPAYRWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADGL
PRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAPGLPIAGRPGEVPPNVP
GTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGPPAPPGPGPQLPAPFINPGGTGGSG
VTGGSEN"
gene 202476..204068
/gene="mce1D"
/locus_tag="Rv0172"
CDS 202476..204068
/codon_start=1
/transl_table=11
/gene="mce1D"
/locus_tag="Rv0172"
/product="Mce-family protein Mce1D"
/note="Rv0172, (MTCI28.12), len: 530 aa. Mce1D; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07786|Rv0592|MTCY19H5.30c|mce2D
(508 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc.
Also highly similar to others e.g. NP_302659.1|NC_002677
putative secreted protein from Mycobacterium leprae (531
aa); CAC12795.1|AL445327 putative secreted protein from
Streptomyces coelicolor (337 aa); etc. Hydrophobic region
at N-terminus. Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0172"
/db_xref="EnsemblGenomes-Tr:CCP42898"
/db_xref="GOA:O07416"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="InterPro:IPR024516"
/db_xref="UniProtKB/TrEMBL:O07416"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42898.1"
/translation="MSTIFDIRNLRLPQLSRASVVIGSLVVVLALAAGIVGVRLYQKL
TNNTVVAYFTQANALYVGDKVQIMGLPVGSIDKIEPAGDKMKVTFHYQNKYKVPANAS
AVILNPTLVASRNIQLEPPYRGGPVLADNAVIPVERTQVPTEWDELRDSVSHIIDELG
PTPEQPKGPFGEVIEAFADGLAGKGKQINTTLNSLSQALNALNEGRGDFFAVVRSLAL
FVNALHQDDQQFVALNKNLAEFTDRLTHSDADLSNAIQQFDSLLAVARPFFAKNREVL
THDVNNLATVTTTLLQPDPLDGLETVLHIFPTLAANINQLYHPTHGGVVSLSAFTNFA
NPMEFICSSIQAGSRLGYQESAELCAQYLAPVLDAIKFNYFPFGLNVASTASTLPKEI
AYSEPRLQPPNGYKDTTVPGIWVPDTPLSHRNTQPGWVVAPGMQGVQVGPITQGLLTP
ESLAELMGGPDIAPPSSGLQTPPGPPNAYDEYPVLPPIGLQAPQVPIPPPPPGPDVIP
GPVPPTPAPVGAPLPAEAGGGQ"
gene 204065..205237
/gene="lprK"
/gene_synonym="mce1E"
/locus_tag="Rv0173"
CDS 204065..205237
/codon_start=1
/transl_table=11
/gene="lprK"
/gene_synonym="mce1E"
/locus_tag="Rv0173"
/product="Possible Mce-family lipoprotein LprK (Mce-family
lipoprotein Mce1E)"
/note="Rv0173, (MTCI28.13), len: 390 aa. Possible lprK
(alternate gene name: mce1E), lipoprotein which belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07785|LPRL|Rv0593|MTCY19H5.29|mce2E
(402 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa);
etc. Also highly similar to others e.g.
NP_302660.1|NC_002677 putative lipoprotein from
Mycobacterium leprae (392 aa); CAC12794.1|AL445327
putative secreted protein from Streptomyces coelicolor
(413 aa); etc. Contains PS00013 prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0173"
/db_xref="EnsemblGenomes-Tr:CCP42899"
/db_xref="GOA:O07417"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O07417"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42899.1"
/translation="MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGG
PGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLKKDVTL
PKNATAKIGQTSLLGSQHVELAAPPDPSPVPLKDGDTIPLKRSSAYPTTEQTLASIAT
LLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNR
LLAYVGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGDL
HQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYS
AIDNAFLTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC"
gene 205231..206778
/gene="mce1F"
/locus_tag="Rv0174"
CDS 205231..206778
/codon_start=1
/transl_table=11
/gene="mce1F"
/locus_tag="Rv0174"
/product="Mce-family protein Mce1F"
/note="Rv0174, (MTCI28.14), len: 515 aa. Mce1F; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), similar to Mycobacterium
tuberculosis proteins O07784|Rv0594|MTCY19H5.28c|mce2F
(516 aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc.
Also highly similar to others e.g. NP_302661.1|NC_002677
putative secreted protein from Mycobacterium leprae (516
aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from
Mycobacterium avium (80 aa) (similarity on C-terminus);
CAC12793.1|AL445327 putative secreted protein from
Streptomyces coelicolor (433 aa); etc. Has hydrophobic
stretch, possibly a signal peptide at the N-terminus.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0174"
/db_xref="EnsemblGenomes-Tr:CCP42900"
/db_xref="GOA:L0T2W6"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:L0T2W6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42900.1"
/translation="MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKA
DLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVHSVS
AVGEQYIDLVSTGAPGKYFSSGQTITKGTVPSEIGPALDNSNRGLAALPTEKIGLLLD
ETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERW
ARKLNNLAAQTATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLK
RYHAGVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSP
ADTSPRPLPSGTYCKIPQDAQLQVRGARNIPCVDVLGKRAATPKECRSKDPYVPLGTN
PWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQ
RPGSGTVQCNGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWK
EMLAPAS"
repeat_region 206812..206850
/note="39 bp direct repeat
1,AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG"
gene 206814..207455
/locus_tag="Rv0175"
CDS 206814..207455
/codon_start=1
/transl_table=11
/locus_tag="Rv0175"
/product="Probable conserved Mce associated membrane
protein"
/note="Rv0175, (MTCI28.15), len: 213 aa. Probable
conserved Mce-associated membrane protein, equivalent, but
longer in N-terminus, to CAC32127.1|AL583926 possible
membrane protein from Mycobacterium leprae (182 aa). Also
similar to mce-associated proteins from Mycobacterium
tuberculosis e.g. Rv1363c, Rv0177, Rv1973, etc. Contains
two 12 residue direct repeats at N-terminus. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0175"
/db_xref="EnsemblGenomes-Tr:CCP42901"
/db_xref="GOA:O07419"
/db_xref="UniProtKB/TrEMBL:O07419"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42901.1"
/translation="MKAADSAESDAGADQTGPQVKAADSAESDAGELGEDACPEQALV
ERRPSRLRRGWLVGIAATLLALAGGLGAAGYFALRSHQESQSIAREDLAAIEAAKDCV
AATQAPDAGAMSASMQKIIECGTGDFGAQASLYTSMLVEAYQAASVHVQVTDMRAAVE
RNNNDGSVDVLVALRVKVSNTDSDAHEVGYRLRVRMALDEGRYKIAKLDQVTK"
repeat_region 206869..206907
/locus_tag="Rv0175"
/note="39 bp direct repeat
2,AGGTGAAGGCGGCGGATTCGGCGGAATCTGACGCCGGAG"
gene 207452..208420
/locus_tag="Rv0176"
CDS 207452..208420
/codon_start=1
/transl_table=11
/locus_tag="Rv0176"
/product="Probable conserved Mce associated transmembrane
protein"
/note="Rv0176, (MTCI28.16), len: 322 aa. Probable
conserved Mce-associated transmembrane protein. Contains
short region of similarity to PRA_MYCLE|P41484
proline-rich antigen (36 kDa antigen) from Mycobacterium
leprae (249 aa) (outside the proline-rich region), FASTA
scores: opt: 165, E(): 2.9e-05, (40.0% identity in 65 aa
overlap). Also similar to mce-associated proteins from
Mycobacterium tuberculosis e.g. Rv1363c, Rv0177, Rv3493c,
etc. A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0176"
/db_xref="EnsemblGenomes-Tr:CCP42902"
/db_xref="GOA:O07420"
/db_xref="InterPro:IPR010432"
/db_xref="UniProtKB/TrEMBL:O07420"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42902.1"
/translation="MTVVVEKTPTTLPQATPNGAAPWHVRAGAFAIDVLPGLAVAATM
ALTALTVPPGSAWRWLCACLLGLTILLLAVNRLLLPTITGWSLGRALTGIRVVRRDGS
AIGPWRLLVRDLAHLVDTLSLFVGWLWPLWDSRRRTFADLLLRTEVRRVEPVQRPAVI
RRLTAAVALAAAGACASATAVGAAVVYVNEWQTDHTRAQLATRGPKLVVDVLSYDPET
VQRDFERARSLATDRYRPQLSIQQDSVRESGPVRNQYWVTDSAVLSATPAQATMLLFM
QGERGTPPNQRYIQSTVRAIFQKSRGQWRLDDLAVVMKPRQPTGEK"
gene 208417..208971
/locus_tag="Rv0177"
CDS 208417..208971
/codon_start=1
/transl_table=11
/locus_tag="Rv0177"
/product="Probable conserved Mce associated protein"
/note="Rv0177, (MTCI28.17), len: 184 aa. Probable
conserved Mce-associated protein, equivalent to
CAC32129.1|AL583926 conserved membrane protein from
Mycobacterium leprae (184 aa). Also similar to
mce-associated proteins from Mycobacterium tuberculosis
e.g. Rv1363c, Rv1973, Rv3493c,etc. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0177"
/db_xref="EnsemblGenomes-Tr:CCP42903"
/db_xref="GOA:O07421"
/db_xref="UniProtKB/TrEMBL:O07421"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42903.1"
/translation="MSPRRKFEPGEGALLAPQSIEPSRRWGLPLALTASAVVMAAAIS
ACALMRISHESHQRAAHKDIVMLSDVRSFMTMFTSPDPFHANEYAERVLSHATGDFAK
QYHERANDILIRISGVEPTTGTVLDAGVQRWNEDGSANVLVVTQITSKSADGKRVVSN
ANRWLVTAKQEGNEWKISSLLPVI"
gene 208938..209672
/locus_tag="Rv0178"
CDS 208938..209672
/codon_start=1
/transl_table=11
/locus_tag="Rv0178"
/product="Probable conserved Mce associated membrane
protein"
/note="Rv0178, (MTCI28.18), len: 244 aa. Probable
conserved Mce-associated membrane protein, highly similar
in C-terminus to CAC32130.1|AL583926 putative secreted
protein from Mycobacterium leprae (184 aa). Also similar
to mce-associated proteins from Mycobacterium tuberculosis
e.g. Rv1363c, Rv0177, Rv1973, etc. Note that there is a 10
aa overlap with the upstream ORF. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0178"
/db_xref="EnsemblGenomes-Tr:CCP42904"
/db_xref="GOA:O07422"
/db_xref="UniProtKB/TrEMBL:O07422"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42904.1"
/translation="MEDQQSASGDLTQKSVANGESTDTASAATEGHRGEIDAAGEPDE
RGAAVADSQADEDDSAATAARGGKTRARRSRGRRLAITVGVAAALFVGSAAFAGATVE
PYLSERAVVATKLMVARTAANAITTLWTYTPENMDTLADRAANYLSGDFAAQYRRFVD
QIAAANKQAKITNDTEVTGAAVESLSGRDAVAIVYTNTTTTSPVTKNIPALKYLSYRL
FMKRYDARWLVTRMTTITSLDLTPQV"
gene complement(209703..210812)
/gene="lprO"
/locus_tag="Rv0179c"
CDS complement(209703..210812)
/codon_start=1
/transl_table=11
/gene="lprO"
/locus_tag="Rv0179c"
/product="Possible lipoprotein LprO"
/note="Rv0179c, (MTCI28.19c), len: 369 aa. Possible
lprO,lipoprotein (visibly not conserved). Contains
possible N-terminal signal sequence and PS00013
Prokaryotic membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0179c"
/db_xref="EnsemblGenomes-Tr:CCP42905"
/db_xref="GOA:O07423"
/db_xref="InterPro:IPR018711"
/db_xref="UniProtKB/TrEMBL:O07423"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP42905.1"
/translation="MWIRAERVAVLTPTASLRRLTACYAALAVCAALACTTGQPAARA
ADGREMLAQAIATTRGSYLVYNFGGGHPMPLLNAGGHWYEMNNGGHLMIIKNASQRLS
PHLLVDTHTGDQARCEHNPGARTGEGLWQASEIYPPLKAWQRMGRPTIAVNANFFDVR
GQKGGSWRSTGCSSPLGAYVDNTRGQGRANQAVTGTVAYAGKQGLSGGNELWSSLTTM
ILPVGGAPYVLRPKSRQDYDLATPVIEDLLNKNARFVAVAGIGLLSPGNTGQLHDGGP
SAARTALAYAKQKDEMYIFQGGNYTPDNIQDLFRGLGSDTAILLDGGGSSAIVLRRDT
GGMWAGAGSPKGSCDTRQVLCDSHERALPSWLAFN"
gene complement(210892..212250)
/locus_tag="Rv0180c"
CDS complement(210892..212250)
/codon_start=1
/transl_table=11
/locus_tag="Rv0180c"
/product="Probable conserved transmembrane protein"
/note="Rv0180c, (MTCI28.20c), len: 452 aa. Probable
conserved transmembrane protein, equivalent to
CAC32132.1|AL583926 probable conserved membrane protein
from Mycobacterium leprae (465 aa). Shows some similarity
with others membrane proteins e.g. AL096849|SCI11_29 from
Streptomyces coelicolor (354 aa), FASTA scores: opt:
190,E(): 0.00067, (25.9% identity in 409 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0180c"
/db_xref="EnsemblGenomes-Tr:CCP42906"
/db_xref="GOA:O07424"
/db_xref="InterPro:IPR022703"
/db_xref="UniProtKB/TrEMBL:O07424"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42906.1"
/translation="MSQAQPRPAAPNPKRNVKAIRTVRFWMAPIATTLALMSALAALY
LGGILNPMTNLRHFPIALVNEDAGPAGQQIVDGLVSGLDKNKFDIRVVSPDEARRLLD
TAAVYGSALIPPTFSSQLRDFGASAVTPTRTDRPAITISTNPRAGTLAASIAGQTLTR
ALTVVNGKVGERLTAEVAAQTGGVALAGAAAAGLASPIDVKSTAYNPLPNGTGNGLSA
FYYALLLLLAGFTGSIVVSTLVDSMLGYVPAEFGPVYRFAEQVNISRFRTLLVKWAVM
VVLALLTSGVYLAIAHGLGMPIPLGWQVWLYGVFAIIAVGVTSSSLIAVLGSMGLLVS
MLIFVILGLPSAGATVPLEAVPAFFRWLAQFEPMHQVFLGVRSLLYLNGNADAGLSQA
LTMTSIGLIIGLLLGGFITHLYDRSSFHRIPGAVEMAIAVEHQAQYQARQSARESSSE
QP"
gene complement(212277..213011)
/locus_tag="Rv0181c"
CDS complement(212277..213011)
/codon_start=1
/transl_table=11
/locus_tag="Rv0181c"
/product="Conserved hypothetical protein"
/note="Rv0181c, (MTCI28.21c), len: 244 aa. Conserved
hypothetical protein, highly similar to other hypothetical
proteins e.g. YHHW_ECOLI|P46852 hypothetical 26.3 kd
protein from Escherichia coli (231 aa), FASTA scores: opt:
479, E(): 1.2e-29, (37.3% identity in 233 aa overlap);
P73623|SLL1773 hypothetical 25.7 kDa protein from
Synechocystis sp. strain PCC 6803 (232 aa), FASTA score:
(39.1% identity in 233 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0181c"
/db_xref="EnsemblGenomes-Tr:CCP42907"
/db_xref="GOA:P9WI85"
/db_xref="InterPro:IPR003829"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR012093"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR041602"
/db_xref="UniProtKB/Swiss-Prot:P9WI85"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42907.1"
/translation="MTATVEIRRAADRAVTTTSWLKSRHSFSFGDHYDPDNTHHGLLL
VNNDDQMEPASGFDPHPHRDMEIVTWVLRGALRHQDSAGNSGVIYPGLAQRMSAGTGI
LHSEMNDSATEPVHFVQMWVIPDATGITASYQQQEIDDELLRAGLVTIASGIPGQDAA
LTLHNSSASLHGARLRPGATVSLPCAPFLHLFVAYGRLTLEGGGELADGDAVRFTDAD
ARGLTANEPSEVLIWEMHAKLGDSAT"
gene complement(213028..214140)
/gene="sigG"
/locus_tag="Rv0182c"
CDS complement(213028..214140)
/codon_start=1
/transl_table=11
/gene="sigG"
/locus_tag="Rv0182c"
/product="Probable alternative RNA polymerase sigma factor
SigG (RNA polymerase ECF type sigma factor)"
/note="Rv0182c, (MTCI28.22c), len: 370 aa (start site
uncertain; first of several possibles was chosen, but note
that this overlaps the upstream ORF). Probable
sigG,alternative RNA polymerase sigma subunit (see
citations below), similar to many e.g. Q45585|SIGW_BACSU
RNA polymerase sigma factor from Bacillus subtilis (187
aa). Also similar to nine other ECF sigma factors from
Mycobacterium tuberculosis e.g. Rv1221, Rv0735, etc.
Contains PS01063 Sigma-70 factors ECF subfamily signature
and probable helix-turn helix motif from aa 205-226 (Score
1181, +3.21 SD). Belongs to the sigma-70 factor family,
ECF subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0182c"
/db_xref="EnsemblGenomes-Tr:CCP42908"
/db_xref="GOA:P9WGG5"
/db_xref="InterPro:IPR000838"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR014305"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR037401"
/db_xref="InterPro:IPR039425"
/db_xref="UniProtKB/Swiss-Prot:P9WGG5"
/inference="protein motif:PROSITE:PS01063"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42908.1"
/translation="MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAE
NSGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFA
GKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPD
VTDDPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTST
VAVNSLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTA
EAIWEMPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVH
LPFQLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL"
gene 214088..214927
/locus_tag="Rv0183"
CDS 214088..214927
/codon_start=1
/transl_table=11
/locus_tag="Rv0183"
/product="Possible lysophospholipase"
/note="Rv0183, (MTCI28.23), len: 279 aa. Possible
lysophospholipase, similar to several (especially
eukaryotic enzymes, weaker with Escherichia coli), e.g.
U67963|HSU67963_1 Human lysophospholipase homolog from
Homo sapiens (313 aa), FASTA scores: opt: 569, E():
2.6e-29,(37.1% identity in 259 aa overlap);
P07000|PLDB_ECOLI lysophospholipase L2 from Escherichia
coli (165 aa), FASTA scores: opt: 219, E(): 0.00012. Start
changed based on similarity to AE001997_8 from Deinococcus
radiodurans (282 aa), FASTA scores: opt: 510, E():
1.4e-25, (34.8% identity in 282 aa overlap). Also shows
some similarity to epoxide hydrolases from Mycobacterium
tuberculosis e.g. Rv1938 FASTA score: (30.7% identity in
114 aa overlap); and
O07214|YR15_MYCTU|Rv2715|MT2788|MTCY05A6.36 (341 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0183"
/db_xref="EnsemblGenomes-Tr:CCP42909"
/db_xref="GOA:O07427"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR022742"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:6EIC"
/db_xref="UniProtKB/Swiss-Prot:O07427"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42909.1"
/translation="MTTTRTERNFAGIGDVRIVYDVWTPDTAPQAVVVLAHGLGEHAR
RYDHVAQRLGAAGLVTYALDHRGHGRSGGKRVLVRDISEYTADFDTLVGIATREYPGC
KRIVLGHSMGGGIVFAYGVERPDNYDLMVLSAPAVAAQDLVSPVVAVAAKLLGVVVPG
LPVQELDFTAISRDPEVVQAYNTDPLVHHGRVPAGIGRALLQVGETMPRRAPALTAPL
LVLHGTDDRLIPIEGSRRLVECVGSADVQLKEYPGLYHEVFNEPERNQVLDDVVAWLT
ERL"
gene 214969..215718
/locus_tag="Rv0184"
CDS 214969..215718
/codon_start=1
/transl_table=11
/locus_tag="Rv0184"
/product="Conserved hypothetical protein"
/note="Rv0184, (MTCI28.24), len: 249 aa. Conserved
hypothetical protein, equivalent to CAC32136.1|AL583926
conserved hypothetical protein from Mycobacterium leprae
(249 aa); and C-terminus highly similar to
CAB08793.1|Z95398 conserved hypothetical protein from
Mycobacterium leprae (145 aa), FASTA scores: E(): 0, (75.2
identity in 145 aa overlap). Also similar to
049841|SCE9_39|T36358 hypothetical protein from
Streptomyces coelicolor (418 aa), FASTA scores: opt:
231,E(): 8.1e-08, (30.4% identity in 270 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0184"
/db_xref="EnsemblGenomes-Tr:CCP42910"
/db_xref="InterPro:IPR024498"
/db_xref="UniProtKB/TrEMBL:O07428"
/protein_id="CCP42910.1"
/translation="MTNDKMLARIAALLRQAEGTDNPHEADAFMSTAQRLATAASIDL
AVARSHAGNRSPAQAPTQRTITIGAAGTRGLRTYVQLFVLIAAANDVRCDVASNSTFV
YAYGFAEDIDTSHALYASLVVQMVRASDAYLASGAHRPTPTITARLNFQLAFGARVGQ
RLADAREQTRQEATKDRDRPPGTAIALRDKDIELHEYYRRSSKARGAWRASRATAGYS
SAARRAGDRAGRQARLGNNPELPGARAALGR"
gene 215715..216224
/locus_tag="Rv0185"
CDS 215715..216224
/codon_start=1
/transl_table=11
/locus_tag="Rv0185"
/product="Conserved hypothetical protein"
/note="Rv0185, (MTCI28.25a), len: 169 aa. Conserved
hypothetical protein, equivalent to
CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168
aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in
165 aa overlap). Contains PS00142 Neutral zinc
metallopeptidases, zinc-binding region signature. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0185"
/db_xref="EnsemblGenomes-Tr:CCP42911"
/db_xref="InterPro:IPR027595"
/db_xref="UniProtKB/TrEMBL:O07429"
/inference="protein motif:PROSITE:PS00142"
/protein_id="CCP42911.1"
/translation="MIGADVPRDSQRARVYAAEAFVRTLFDRVTAHGSPTVEFFGTQL
TLPPEGRFGSVASVQRYVDDVLALPAVGQNWPTVSPVRVRARRAATAAHYENHGGTGT
IAVPDRHTAGWAMRELVVLHEVAHHLCQVPPPHGPEFVATVCTLTELVMGPEVGHVFR
VVYAQEGVR"
gene 216269..218344
/gene="bglS"
/locus_tag="Rv0186"
CDS 216269..218344
/codon_start=1
/transl_table=11
/gene="bglS"
/locus_tag="Rv0186"
/product="Probable beta-glucosidase BglS (gentiobiase)
(cellobiase) (beta-D-glucoside glucohydrolase)"
/note="Rv0186, (MTCI28.25b), len: 691 aa. Probable
bglS,beta-glucosidase, highly similar to many e.g.
BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium
tumefaciens (818 aa), FASTA scores: opt: 643, E():
0,(32.5% identity in 842 aa overlap). Seems to belong to
family 3 of glycosyl hydrolases."
/db_xref="EnsemblGenomes-Gn:Rv0186"
/db_xref="EnsemblGenomes-Tr:CCP42912"
/db_xref="GOA:O07430"
/db_xref="InterPro:IPR001764"
/db_xref="InterPro:IPR002772"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR026891"
/db_xref="InterPro:IPR036881"
/db_xref="InterPro:IPR036962"
/db_xref="UniProtKB/TrEMBL:O07430"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42912.1"
/translation="MTDDERFSLLVGLTGASDLWPVRDERIPQGVPMCAGYVPGIPRL
GVPALLMSDAGLGVTNPGYRPGDTATALPAGLALAASFNPVLARSSGKAIGREARSRG
FNVQLAGAINLARDPRNGRNFEYLSEDPLLSATMAAESIIGIQQQGVIATTKHFSLNC
NETNRHWLDAVIDPDAHRESDLLAFEIVIERSQPGAVMAAYNKVNGDYAAGNDHLLND
VLKGAWGYRGWVMSDWGGTPSWECALAGLDQECGAQIDAVLWQSEAFTDRLRAAYADG
NLPKGRLSDMVRRILRSMFAVGIDRWKPAPAPDMNAHNEIAAQMARQGIVLLQNRGLL
PLAPESAGRIAVIGGYAHLGVPAGYGSSAVTPPGGYAGVIPIGGSGLAAGLRNLYLLP
SSPLSELRKRLPNAQFEFDPGINPAEAVLAARRADIAIVFAIRAEGEGFDSADLSLPW
GQDALIAAVASANANTVVVLETGNPVTMPWRDSVNAIMQAWYPGQAGGQAVAEIVTGQ
VNPSGRLPITFPVDLGQTPRSQPPELGAPWGTSTTIHYTEGADVGYRWFASTNQTPMF
AFGHGLSYTSFEYRDLVVTGGHTVHASFSVTNTGDRSGADVPQLYMIAAPGESRLRLL
GFERVELEPGQTRRVRIEADPRLLARYDGEARSWRIEPGGYTVAVGASAVALKLAAKV
KLAGRGFGR"
gene complement(218390..218551)
/gene="mymT"
/locus_tag="Rv0186A"
CDS complement(218390..218551)
/codon_start=1
/transl_table=11
/gene="mymT"
/locus_tag="Rv0186A"
/product="Metallothionein, MymT"
/note="Rv0186A, len: 53 aa. MymT,
metallothionein,equivalent to MAV_4993|A0QMH5 hypothetical
protein from Mycobacterium avium (strain 104) (51 aa), and
MAP_3626c|Q73TU2 hypothetical protein from Mycobacterium
avium subsp. paratuberculosis (51 aa), FASTA scores: opt:
312, E(): 4.6e-17, (81.2% identity in 48 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0186A"
/db_xref="EnsemblGenomes-Tr:CCP42913"
/db_xref="GOA:P9WK09"
/db_xref="UniProtKB/Swiss-Prot:P9WK09"
/protein_id="CCP42913.1"
/translation="MRVIRMTNYEAGTLLTCSHEGCGCRVRIEVPCHCAGAGDAYRCT
CGDELAPVK"
gene 218705..219367
/locus_tag="Rv0187"
CDS 218705..219367
/codon_start=1
/transl_table=11
/locus_tag="Rv0187"
/product="Probable O-methyltransferase"
/note="Rv0187, (MTCI28.26), len: 220 aa. Probable
O-methyltransferase, similar to many e.g.
AB93458.1|AL357591 putative O-methyltransferase from
Streptomyces coelicolor (223 aa); MDMC_STRMY|Q00719
O-methyltransferase from Streptomyces mycarofaciens (221
aa), FASTA scores: opt: 327, E(): 2.4e-17, (35.9% identity
in 192 aa overlap). Also similar to Rv1703c, Rv1220c from
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0187"
/db_xref="EnsemblGenomes-Tr:CCP42914"
/db_xref="GOA:O07431"
/db_xref="InterPro:IPR002935"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O07431"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42914.1"
/translation="MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAV
SAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVAR
VNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVAYIQWAIRLARRGA
VIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALAL
VR"
gene 219486..219917
/locus_tag="Rv0188"
CDS 219486..219917
/codon_start=1
/transl_table=11
/locus_tag="Rv0188"
/product="Probable conserved transmembrane protein"
/note="Rv0188, (MTCI28.27), len: 143 aa. Probable
conserved transmembrane protein, similar to
T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable
membrane protein from Streptomyces coelicolor (147
aa),FASTA scores: opt: 326, E(): 6.5e-15, (36.2% identity
in 141 aa overlap); N-terminus of P80185|MTRC_METTH
tetrahydromethanopterin S-methyltransferase subunit C from
Methanobacterium thermoautotrophicum strain Marburg/DSM
2133 (266 aa), FASTA scores: opt: 125, E(): 0.033, (31.6%
identity in 98 aa overlap). Also similar to Rv3635 from
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0188"
/db_xref="EnsemblGenomes-Tr:CCP42915"
/db_xref="GOA:O07432"
/db_xref="InterPro:IPR005530"
/db_xref="UniProtKB/TrEMBL:O07432"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42915.1"
/translation="MSTVHSSIDQHPDLLALRASFDRAAESTIAHFTFGLALLAGLYV
AASPWIVGFSATRGLPTCDLIVGIAVAYLAYGFASALDRTHGMTWTLPVLGVWVIFSP
WVLPGVAVTAGMMWSHIIAGAVVAVLGFYFGMRTRAAANQG"
gene complement(219996..221723)
/gene="ilvD"
/locus_tag="Rv0189c"
CDS complement(219996..221723)
/codon_start=1
/transl_table=11
/gene="ilvD"
/locus_tag="Rv0189c"
/product="Probable dihydroxy-acid dehydratase IlvD (dad)"
/note="Rv0189c, (MTCI28.28c), len: 575 aa. Probable
ilvD,dihydroxy-acid dehydratase, similar to many e.g.
ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) from
Lactococcus lactis (subsp. lactis) (Streptococcus lactis)
(570 aa), FASTA scores: opt: 1605, E(): 0, (46.0% identity
in 561 aa overlap). Also similar to
ML2608|MLCL622.06c|O06069|ILVD_MYCLE dihydroxy-acid
dehydratase from Mycobacterium leprae (564 aa). Contains
PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases
signature 1. Belongs to the ILVD / EDD family. Cofactor:
binds 1 4FE-4S cluster (potential)."
/db_xref="EnsemblGenomes-Gn:Rv0189c"
/db_xref="EnsemblGenomes-Tr:CCP42916"
/db_xref="GOA:P9WKJ5"
/db_xref="InterPro:IPR000581"
/db_xref="InterPro:IPR004404"
/db_xref="InterPro:IPR020558"
/db_xref="InterPro:IPR037237"
/db_xref="InterPro:IPR042096"
/db_xref="UniProtKB/Swiss-Prot:P9WKJ5"
/inference="protein motif:PROSITE:PS00886"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42916.1"
/translation="MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDD
EDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVFSAGGYPLEFGTISVSDGISMGH
EGMHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYA
GSILPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGACGGMY
TANTMASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLRRGITARDILTKEA
FENAIAVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGVPHLADVKPFGRHVM
SDVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPI
HPSGGITILHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAALDALEDGTITVGDAV
VIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHIAPEAVD
GGPIALLRNGDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLVS
SAAVGAVCG"
gene 221871..222161
/locus_tag="Rv0190"
CDS 221871..222161
/codon_start=1
/transl_table=11
/locus_tag="Rv0190"
/product="Conserved protein"
/note="Rv0190, (MTCI28.29), len: 96 aa. Conserved
protein,highly similar to several hypothetical proteins
e.g. SYCSLRA_35|Q55554|SLL0176 hypothetical 18.9 kDa
protein from Synechocystis (167 aa), FASTA scores: opt:
237, E(): 5.8e-16, (39.4% identity in 94 aa overlap). Also
highly similar to Z95398|MLCL622_7|O06070 from
Mycobacterium leprae (135 aa), FASTA score: (82.6%
identity in 92 aa overlap). Also similar to hypothetical
proteins from Mycobacterium tuberculosis e.g. Rv0967,
Rv0030, Rv1766 (42.5% identity in 80 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0190"
/db_xref="EnsemblGenomes-Tr:CCP42917"
/db_xref="GOA:O07434"
/db_xref="InterPro:IPR003735"
/db_xref="InterPro:IPR038390"
/db_xref="UniProtKB/Swiss-Prot:O07434"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42917.1"
/translation="MTAAHGYTQQKDNYAKRLRRVEGQVRGIARMIEEDKYCIDVLTQ
ISAVTSALRSVALNLLDEHLSHCVTRAVAEGGPGADGKLAEASAAIARLVRS"
gene 222289..223530
/locus_tag="Rv0191"
CDS 222289..223530
/codon_start=1
/transl_table=11
/locus_tag="Rv0191"
/product="Probable conserved integral membrane protein"
/note="Rv0191, (MTCI28.30), len: 413 aa. Probable
conserved integral membrane protein, member of major
facilitator superfamily (MFS) possibly involved in
transport of drug,similar to several hypothetical proteins
e.g. YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from
Escherichia coli (396 aa), FASTA scores: opt: 475, E():
4.2e-33, (29.7% identity in 381 aa overlap); and to
several chloramphenicol resistance proteins e.g.
CMLR_STRLI|P31141 chloramphenicol resistance protein from
Streptomyces lividans (392 aa), FASTA scores: opt: 394,
E(): 6.7e-12,(28.2% identity in 383 aa overlap). Also
similar to SVU09991_1 from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0191"
/db_xref="EnsemblGenomes-Tr:CCP42918"
/db_xref="GOA:P9WJX7"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJX7"
/protein_id="CCP42918.1"
/translation="MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILPVGAL
SAIARNLRVSVVLVGTLLSWYALVAAVTTVPLVRWTAHWPRRRALVVSLVCLTVSQLV
SALAPNFAVLAAGRVLCAVTHGLLWAVIAPIATRLVPPSHAGRATTSIYIGTSLALVV
GSPLTAAMSLMWGWRLAAVCVTGAAAAVALAARLALPEMVLRADQLEHVGRRARHHRN
PRLVKVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLLAAYGVAGLVSVPLVA
RPLDRWPKGAVIVGMTGLTAAFTLLTALAFGERHTAATALLGTGAIVLWGALATAVSP
MLQSAAMRSGGDDPDGASGLYVTAFQIGIMAGALLGGLLYERSLAMMLTASAGLMGVA
LFGMTVSQHLFENPTLSPGDG"
gene 223564..224664
/locus_tag="Rv0192"
CDS 223564..224664
/codon_start=1
/transl_table=11
/locus_tag="Rv0192"
/product="Conserved hypothetical protein"
/note="Rv0192, (MTCI28.31), len: 366 aa. Conserved
hypothetical protein. Has Gly- Arg-rich region followed by
highly Pro-rich repetitive region near N-terminus. Similar
in C-terminus to other hypothetical proteins e.g.
Q49706|B1496_F2_81|U00013 from Mycobacterium leprae (271
aa), FASTA scores: opt: 375, E(): 3.2e-24, (36.1% identity
in 255 aa overlap); YV09_MYCTU|Q11149|cY20G9.09
hypothetical 47.9 kDa protein from Mycobacterium
tuberculosis (451 aa), FASTA scores: opt: 330, E():
3.2e-13, (35.1% identity in 271 aa overlap). Also similar
to Rv0116c, Rv1433, Rv2518c, Rv0483 from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0192"
/db_xref="EnsemblGenomes-Tr:CCP42919"
/db_xref="GOA:O07436"
/db_xref="InterPro:IPR005490"
/db_xref="InterPro:IPR038063"
/db_xref="InterPro:IPR041280"
/db_xref="UniProtKB/Swiss-Prot:O07436"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42919.1"
/translation="MPHWAEERHRRESNYVALEAGLDEGESIRRSEHSRSGCGADAGC
WRCRGGPGRGSRRSRRSRGPGGTAGPVDPPAVDLLAPPPDPLALPPALDPLAPPPPDP
LAPPPPDPLAVPVAAGPVAGQDPTSFVGPPPFRPPTFNPVDGAMVGVAKPIVINFAVP
IADRAMAESAIHISSIPPVPGKFYWMSPTQVRWRPFEFWPANTAVNIDAAGTKSSFRT
GDSLVATADDATHQMTITRNGVVQKTFPMSMGMVSGGHQTPNGTYYVLEKFATVVMDS
STYGVPVNSAQGYKLTVSDAVRIDNSGNFVHSAPWSVADQGKRNVTHGCINLSPANAK
WFYDNFGSGDPVVVKNSVGTYNKNDGAQDWQI"
gene 223607..223909
/locus_tag="Rv0192A"
CDS 223607..223909
/codon_start=1
/transl_table=11
/locus_tag="Rv0192A"
/product="Conserved secreted protein"
/note="Rv0192A, len: 100 aa. Probable N-terminal part of
Rv0192, which is member of family P5.17 with
Rv0116c,Rv1433, Rv2518c, Rv0483. These are all predicted
to be exported/membrane proteins. Rv0192A has typical
N-terminal signal peptide which is functional and was
identified by PhoA fusion screens: O52054 PGB14T-O1
precursor (fragment 45 AA) (see Chubb et al., 1998). Since
Rv0192 misses a signal peptide this suggests that there is
a frameshift in the region of the overlap with Rv0192 but
none found on reinspection of sequence."
/db_xref="EnsemblGenomes-Gn:Rv0192A"
/db_xref="EnsemblGenomes-Tr:CCP42920"
/db_xref="UniProtKB/TrEMBL:Q79FZ8"
/protein_id="CCP42920.1"
/translation="MSRWKQGWTRGSLFAALNIAAVVAVLMLGAGVAVADPDAAPGDP
GGPGAPGAQRDPSTRRQLTCWRRHPTRWRCRRHLTRWRRRHLTRSRRPRLTRWQCR"
gene complement(224724..226571)
/locus_tag="Rv0193c"
CDS complement(224724..226571)
/codon_start=1
/transl_table=11
/locus_tag="Rv0193c"
/product="Hypothetical protein"
/note="Rv0193c, (MTV033.01c-MTCI28.32), len: 615 aa.
Hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0193c"
/db_xref="EnsemblGenomes-Tr:CCP42921"
/db_xref="UniProtKB/TrEMBL:O07437"
/protein_id="CCP42921.1"
/translation="MIQISRDMSSLGQTATTQALPDNSDGIQLTKFAADDILPLEYAP
PIGPELVSQDQLPAAWAYKRFRDLDDKESYRRKLLQELTDALAAQGSEAAEIATAALR
DLIDQMAEQGAVVLADIVESDDFLELVKRYDELMAREGSRSFIHRFLDLRRSPGMLTD
PAVNGALVHPLMIALISYAVGGPIRMIDARGKDAEPLSVLAQDNMLHIDNTPFNDEYK
ILITWRRGTAQGPAGQNFTFLPGTHKLARTCFVNEDGVPWSSENASIFTTPDSIRKVF
DAQRQLGGQDHPTVIEVTDSERPLSGVFAAGSLVHHRFRTASGSARSCIILVFHRVAD
NPGRMVSDVEDSSDVSLSELLTRGVPDESYQQRFIATLCAAADEIAELLLKWKKTPQR
PVSLPLQTKQIDGARFEEWISAATKAPEVREIRNRELTIPYGEVLSAEEFFDLIWRLM
RFDKHGPLDLILYHDNREEPRKWARNLIREMSADRLYERLLGWLADIQQPRPADCLRP
LQIHALISEVLKTLPLDEDQDPPADWHFDLLGMSHAEAARSVKHLLEDVAEALLRCED
MAAYLSTSLFAFWAVDAAYSLDGRRNLVVKDCARRLLRHYTMLSLTCFQ"
gene 226878..230462
/locus_tag="Rv0194"
CDS 226878..230462
/codon_start=1
/transl_table=11
/locus_tag="Rv0194"
/product="Probable transmembrane multidrug efflux pump"
/note="Rv0194, (MTV033.02), len: 1194 aa. Probable
multidrug efflux pump (See Danilchanka et al.,
2008),highly similar to many e.g. U62129|STU62129_2|T30293
ABC transport protein homolog from Salmonella typhi (1218
aa),FASTA scores: opt: 1116, E(): 0, (36.3% identity in
1209 aa overlap); CAB66302.1|AL136519 ABC transporter
protein ATP-binding component from Streptomyces coelicolor
(1243 aa); I84547 mdl protein from Escherichia coli (1143
aa); etc. Also similar to MTCY50_9 and MTCY50_10 from
Mycobacterium tuberculosis, FASTA score: (33.8% identity
in 574 aa overlap). Contains two PS00017 ATP/GTP-binding
site motif A (P-loop) and one PS00211 ABC transporters
family signature. Belongs to the ATP-binding transport
protein family (ABC transporters). Alternative start
possible at 1823 but no RBS."
/db_xref="EnsemblGenomes-Gn:Rv0194"
/db_xref="EnsemblGenomes-Tr:CCP42922"
/db_xref="GOA:O53645"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="InterPro:IPR039421"
/db_xref="UniProtKB/Swiss-Prot:O53645"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42922.1"
/translation="MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRV
IDDAIAADHRPLAPWAVVLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLR
WDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAVMTWLSVPLAL
LAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERET
VKLVTASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFV
AFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEARLSL
EFQRVSFGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVR
IGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIE
EFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECG
IQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRYRELL
SPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTNVHNPGPHDHPPGPDPLRRLLREFR
GPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIRWVVQ
WGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLR
TGLVVAVISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARH
RLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVA
LLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVA
AGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTV
VFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFA
GTVRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLL
ALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADR
IVVLEHGTVVEDGAHTELLAAGGHYSRLWAAHTRLCSPEITQLQCIDA"
gene 230899..231534
/locus_tag="Rv0195"
CDS 230899..231534
/codon_start=1
/transl_table=11
/locus_tag="Rv0195"
/product="Possible two component transcriptional
regulatory protein (probably LuxR-family)"
/note="Rv0195, (MTV033.03), len: 211 aa. Possible
two-component response regulator, luxR family, similar to
many e.g. U00008|ECOHU49_15 regulatory protein narP from
Escherichia coli strain K12 (225 aa), FASTA scores: opt:
232, E(): 7.3e-09, (29.2% identity in 219 aa overlap).
Start chosen by similarity. Contains probable
helix-turn-helix motif at aa 166-187 (Score 1164, +3.15
SD)."
/db_xref="EnsemblGenomes-Gn:Rv0195"
/db_xref="EnsemblGenomes-Tr:CCP42923"
/db_xref="GOA:O53646"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:O53646"
/protein_id="CCP42923.1"
/translation="MAPVNVISVAVVASDPLTRDGALARLSSHRELDVRAWQAGCETS
VLLVLATTITAPLLCQIEDVQKDGPSHAPKLVVVADEFSAEQVFRMIKLGLTGLLYRS
QSTFDCIVETIRLSAEGRLRLPERVQRYLVGRIKSTPTAEPDTPCAAALAEREVAVLR
LLADGLSTHQVAVQLNYCERTIKNIVHDIVTRLKLRNRTHAVAHALRAGLI"
gene 231647..232231
/locus_tag="Rv0196"
CDS 231647..232231
/codon_start=1
/transl_table=11
/locus_tag="Rv0196"
/product="Possible transcriptional regulatory protein"
/note="Rv0196, (MTV033.04), len: 194 aa. Possible
transcriptional regulatory protein, similar to two
Bacillus subtilis regulators: P42105|YXAF_BACSU
hypothetical 21.0 kDa protein (191 aa), FASTA scores: opt:
323, E(): 2.1e-15,(30.9% identity in 181 aa overlap); and
Z99105|BSUB0002_9 negative regulator of the lincomycin
operon (188 aa), FASTA scores: opt: 255, E(): 1e-10, (25.9
identity in 185 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0196"
/db_xref="EnsemblGenomes-Tr:CCP42924"
/db_xref="GOA:P9WME1"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/Swiss-Prot:P9WME1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42924.1"
/translation="MQGPRERMVVSAALLIRERGAHATAISDVLQHSGAPRGSAYHYF
PGGRTQLLCEAVDYAGEHVAAMINEAEGGLELLDALIDKYRQQLLSTDFRAGCPIAAV
SVEAGDEQDRERMAPVIARAAAVFDRWSDLTAQRFIADGIPPDRAHELAVLATSTLEG
AILLARVRRDLTPLDLVHRQLRNLLLAELPERSR"
gene 232231..234519
/locus_tag="Rv0197"
CDS 232231..234519
/codon_start=1
/transl_table=11
/locus_tag="Rv0197"
/product="Possible oxidoreductase"
/note="Rv0197, (MTV033.05), len: 762 aa. Possible
oxidoreductase, similar to others e.g.
9948789|AAG06102.1|AE004699_7|B83307 probable
molybdopterin oxidoreductase from Pseudomonas aeruginosa
strain PAO1 (769 aa); 5441785|CAB46809.1|AL096811|T36812
probable dehydrogenase from Streptomyces coelicolor (747
aa), FASTA scores: opt: 617, E(): 9.8e-30, (29.9% identity
in 762 aa overlap); BAB04334.1|AP001509 assimilatory
nitrate reductase (catalytic subunit) from Bacillus
halodurans (743 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0197"
/db_xref="EnsemblGenomes-Tr:CCP42925"
/db_xref="GOA:L0T2Z1"
/db_xref="InterPro:IPR006656"
/db_xref="InterPro:IPR006657"
/db_xref="InterPro:IPR006963"
/db_xref="InterPro:IPR009010"
/db_xref="UniProtKB/TrEMBL:L0T2Z1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42925.1"
/translation="MTSSDWLPTACILCECNCGIVVQVDDRRLARIRGDKAHPGSAGY
TCNKALRLDHYQNNRARLSSPMRRRADGTYEEIDWDTAIVEIAEGFKQIRDTHGGDKI
FYYGGGGQGNHLGGAYSGAFLKALGSRYRSNALAQEKTGEAWVDFQLYGGHTRGEFEN
AEVSVFVGKNPWMSQSFPRARVVLNEIAKDPGRSMIVIDPVVTDTAKMADFHLRVQPG
CDAWCLAALAAVLVQENLCNEAFLAAHVHGVDTVRAALQEVPVADYAQRCGVDEELLR
AAARRIGTAASVSVFEDLGIQQAPNSTVCSYLNKLLWILTGNFAKKGGQHLHSSFAPL
FSQVSGRTPVTGAPIIAGLIPGNVVPEEILTEHPDRFRAMIVERGNPAHSLADSAACR
AAFQALELMVVVDVAMTETARLAHYVLPAASQFEKPEATFFNFEFPRNGFQLRRPLFP
PLPGTLPEPEIWARLVRALGVVDEADLRPLREAAAQGRQAYTEAFLAAAATNPTVAKL
TAYVLYETLGPTLPDGLAGAAALWGLAQKTAMAYPDAVRRAGHADGNALFDAILERPS
GVTFTVHNYEDDFALISHPDHKIALEIPEMLAEIRSLTQTPSRLTTPQLPIVLSVGER
RAYTANDIFRDPSWRKRDANGALRVSVEDAQALGLADGCLARITTAAGSAEATVEVTE
TMLAGHAALPNGFGLDYTGDDGRTVVAGVAPNALTSTRWRDPYAGTPWHKHVPAAIRR
ADAESPIWYPKWAILPARGVLA"
gene complement(234516..236507)
/gene="zmp1"
/locus_tag="Rv0198c"
CDS complement(234516..236507)
/codon_start=1
/transl_table=11
/gene="zmp1"
/locus_tag="Rv0198c"
/product="Probable zinc metalloprotease Zmp1"
/note="Rv0198c, (MTV033.06c), len: 663 aa. Probable
zmp1,zinc metalloprotease, equivalent to
Z95398|MLCL622.12c from Mycobacterium leprae (667 aa),
FASTA scores: opt: 3710,E(): 0, (80.8 % identity in 667 aa
overlap). Also similar to many other metalloproteases e.g.
members of the eukaryotic neprilysin family:
P08473|NEP_HUMAN neprilysin (749 aa), FASTA scores: opt:
872, E(): 0, (31.1% identity in 692 aa overlap);
Q07744|PEPO_LACLA neutral endopeptidase from Lactococcus
lactis (626 aa), FASTA scores: opt: 862,E(): 0, (30.0%
identity in 654 aa overlap). Contains PS00142 Neutral zinc
metallopeptidases, zinc-binding region signature. Belongs
to peptidase family M13 (zinc metalloprotease); also known
as the neprilysin subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0198c"
/db_xref="EnsemblGenomes-Tr:CCP42926"
/db_xref="GOA:I6X8R2"
/db_xref="InterPro:IPR000718"
/db_xref="InterPro:IPR008753"
/db_xref="InterPro:IPR018497"
/db_xref="InterPro:IPR024079"
/db_xref="InterPro:IPR042089"
/db_xref="UniProtKB/TrEMBL:I6X8R2"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42926.1"
/translation="MTLAIPSGIDLSHIDADARPQDDLFGHVNGRWLAEHEIPADRAT
DGAFRSLFDRAETQVRDLIIQASQAGAAVGTDAQRIGDLYASFLDEEAVERAGVQPLH
DELATIDSAADATELAAALGTLQRAGVGGGIGVYVDTDSKDSTRYLVHFTQSGIGLPD
ESYYRDEQHAAVLAAYPGHIARMFGLVYGGESRDHAKTADRIVALETKLADAHWDVVK
RRDADLGYNLRTFAQLQTEGAGFDWVSWVTALGSAPDAMTELVVRQPDYLVTFASLWA
SVNVEDWKCWARWRLIRARAPWLTRALVAEDFEFYGRTLTGAQQLRDRWKRGVSLVEN
LMGDAVGKLYVQRHFPPDAKSRIDTLVDNLQEAYRISISELDWMTPQTRQRALAKLNK
FTAKVGYPIKWRDYSKLAIDRDDLYGNVQRGYAVNHDRELAKLFGPVDRDEWFMTPQT
VNAYYNPGMNEIVFPAAILQPPFFDPQADEAANYGGIGAVIGHEIGHGFDDQGAKYDG
DGNLVDWWTDDDRTEFAARTKALIEQYHAYTPRDLVDHPGPPHVQGAFTIGENIGDLG
GLSIALLAYQLSLNGNPAPVIDGLTGMQRVFFGWAQIWRTKSRAAEAIRRLAVDPHSP
PEFRCNGVVRNVDAFYQAFDVTEDDALFLDPQRRVRIWN"
gene 236550..237209
/locus_tag="Rv0199"
CDS 236550..237209
/codon_start=1
/transl_table=11
/locus_tag="Rv0199"
/product="Probable conserved membrane protein"
/note="Rv0199, (MTV033.07), len: 219 aa. Probable
conserved membrane protein, equivalent to
Z95398|MLCL622.13 from Mycobacterium leprae (224 aa),
FASTA scores: opt: 920, E(): 0, (67.7% identity in 220 aa
overlap). Also some similarity to Mce-associated membrane
proteins from Mycobacterium tuberculosis e.g. Rv0178,
Rv0175, etc. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0199"
/db_xref="EnsemblGenomes-Tr:CCP42927"
/db_xref="GOA:O53650"
/db_xref="UniProtKB/TrEMBL:O53650"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42927.1"
/translation="MPDGEQSQPPAQEDAEDDSRPDAAEAAAAEPKSSAGPMFSTYGI
ASTLLGVLSVAAVVLGAMIWSAHRDDSGERTYLTRVMLTAAEWTAVLINMNADNIDAS
LQRLHDGTVGQLNTDFDAVVQPYRQVVEKLRTHSSGRIEAVAIDTVHRELDTQSGAAR
PVVTTKLPPFATRTDSVLLVATSVSENAGAKPQTVHWNLRLDVSDVDGKLMISRLESI
R"
gene 237206..237895
/locus_tag="Rv0200"
CDS 237206..237895
/codon_start=1
/transl_table=11
/locus_tag="Rv0200"
/product="Possible conserved transmembrane protein"
/note="Rv0200, (MTV033.08), len: 229 aa. Possible
conserved transmembrane protein, equivalent to
Z95398|MLCL622.14 from Mycobacterium leprae (229 aa),
FASTA scores: opt: 1147,E(): 0, (74.7% identity in 229 aa
overlap). Also some similarity to Rv1973 from
Mycobacterium tuberculosis (160 aa); and
Rv1362c|Z75555|MTCY02B10_26 (220 aa), FASTA scores: opt:
134, E(): 0.063, (25.8% identity in 159 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0200"
/db_xref="EnsemblGenomes-Tr:CCP42928"
/db_xref="GOA:O53651"
/db_xref="UniProtKB/TrEMBL:O53651"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42928.1"
/translation="MRNAWRLVVFDVLAPLATIAALAAIGVLLGWPLWWVSTCSVLVL
LVVEGVAINFWLLRRDSVTVGTDDDAPGLRLAVVFLCAAAISAAVVTGYLRWTTPDRD
FNRDSREVVHLATGMAETVASFSPSAPAAAVDRAAAMMVPEHAGGFKEQYAKSSADLA
RRGVTAQAATLAAGVEAIGPSAASVAVILRVSQSIPGQPTSQAARALRVTLTKRGSGW
LVLDVTPINAR"
gene complement(237892..238395)
/locus_tag="Rv0201c"
CDS complement(237892..238395)
/codon_start=1
/transl_table=11
/locus_tag="Rv0201c"
/product="Conserved protein"
/note="Rv0201c, (MTV033.09c), len: 167 aa. Conserved
protein, equivalent to Z95398|MLCL622.15c from
Mycobacterium leprae (170 aa), FASTA scores: opt: 646,
E(): 0, (63.9% identity in 158 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0201c"
/db_xref="EnsemblGenomes-Tr:CCP42929"
/db_xref="GOA:O53652"
/db_xref="UniProtKB/TrEMBL:O53652"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42929.1"
/translation="MTLAAEPHPAPPQQPTVAWSEPDVDRRVEFWPTVAIRSALESGD
IATWQRIAAALKRDPYGRTARQVEEVLEGIPATGIANAFWEVLDRARTHLDANERAEV
ARQVGLLLDRSGLQRQEFASRIGVTAQDLTAYLDGIVSPSASLMIRMRRLSDRFVRAK
SVRAADS"
gene complement(238392..241292)
/gene="mmpL11"
/locus_tag="Rv0202c"
CDS complement(238392..241292)
/codon_start=1
/transl_table=11
/gene="mmpL11"
/locus_tag="Rv0202c"
/product="Probable conserved transmembrane transport
protein MmpL11"
/note="Rv0202c, (MTV033.10c), len: 966 aa. Probable
mmpL11,conserved transmembrane transport protein (see
citation below), equivalent to Z95398|MLCL622.16c from
Mycobacterium leprae (1014 aa), FASTA scores: opt: 4076,
E(): 0, (72.8% identity in 1017 aa overlap). Member of RND
superfamily,similar to several putative transport proteins
e.g. P96687 from Bacillus subtilis (724 aa), FASTA scores:
opt: 594,E(): 9.1e-29, (26.9% identity in 717 aa overlap);
etc. Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv0202c"
/db_xref="EnsemblGenomes-Tr:CCP42930"
/db_xref="GOA:P9WJT9"
/db_xref="InterPro:IPR000731"
/db_xref="InterPro:IPR004869"
/db_xref="PDB:4Y0L"
/db_xref="UniProtKB/Swiss-Prot:P9WJT9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42930.1"
/translation="MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEV
AGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTE
APNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYV
IGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITM
GLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMA
TSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFA
RAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVL
GNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRH
RIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQV
DVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAA
AYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQ
TGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATV
VRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPP
SADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWG
QRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDR
LQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPG
RQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR"
gene 241514..241924
/locus_tag="Rv0203"
CDS 241514..241924
/codon_start=1
/transl_table=11
/locus_tag="Rv0203"
/product="Possible exported protein"
/note="Rv0203, (MTV033.11), len: 136 aa. Possible exported
protein (has hydrophobic stretch near N-terminus). Some
similarity to part of U02459|LDU02459_1 hypothetical
protein from Leishmania donovani (741 aa), FASTA score:
opt: 111, E(): 9.1, (30.0% identity in 90 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0203"
/db_xref="EnsemblGenomes-Tr:CCP42931"
/db_xref="GOA:I6X8R5"
/db_xref="InterPro:IPR030937"
/db_xref="InterPro:IPR032407"
/db_xref="InterPro:IPR038378"
/db_xref="PDB:3MAY"
/db_xref="UniProtKB/Swiss-Prot:I6X8R5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42931.1"
/translation="MKTGTATTRRRLLAVLIALALPGAAVALLAEPSATGASDPCAAS
EVARTVGSVAKSMGDYLDSHPETNQVMTAVLQQQVGPGSVASLKAHFEANPKVASDLH
ALSQPLTDLSTRCSLPISGLQAIGLMQAVQGARR"
gene complement(241976..243214)
/locus_tag="Rv0204c"
CDS complement(241976..243214)
/codon_start=1
/transl_table=11
/locus_tag="Rv0204c"
/product="Probable conserved transmembrane protein"
/note="Rv0204c, (MTV033.12c), len: 412 aa. Probable
conserved transmembrane protein (see citation
below),equivalent, but has C-terminal extension, to
Z95398|MLCL622.17c from Mycobacterium leprae (367
aa),FASTA scores: opt: 2002, E(): 0, (82.4% identity in
374 aa overlap). Some similarity to Rv0585c from
Mycobacterium tuberculosis. Nucleotide position 242299 in
the genome sequence has been corrected, C:G resulting in
V306L."
/db_xref="EnsemblGenomes-Gn:Rv0204c"
/db_xref="EnsemblGenomes-Tr:CCP42932"
/db_xref="GOA:I6Y748"
/db_xref="InterPro:IPR022791"
/db_xref="UniProtKB/TrEMBL:I6Y748"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42932.1"
/translation="MSHDAPARNLRQRVGALPRTRVGAPPAEGVPPRGKYWWLRWAVL
AIVAIVLAIEVALGWDQLAKAWVSLYRAKWWWLLAAVAAAGASMHSFAQIQRTLLKSA
GVHVKQWRSEAAFYAANSLSTTLPGGPVLSATFLLRQQRIWGASTVVASWQLVMSGVL
QAVGLALLGLGGAFFLGAKNNPFSLLFTLGGFVTLLLLAQAVASRPELIEGIGRRVLS
WANSVRGRPADAGLPKWRETLMQLESVSLGRRDLGVAFGWSLFNWIADVACLGFAAYA
AGDHASVGGLAVAYAAARAVGTIPLMPGGLLVVEAVLVPGLVSSGMPLPSAISAMLIY
RLISWLLIAAIGWVVFFFMFRTESTADSDNDRDPPTDPNLRLVIQPQGTPCDDPVETT
PQGPAPTPDLRPEGGETPPR"
gene 243384..244487
/locus_tag="Rv0205"
CDS 243384..244487
/codon_start=1
/transl_table=11
/locus_tag="Rv0205"
/product="Probable conserved transmembrane protein"
/note="Rv0205, (MTV033.13), len: 367 aa. Possible
conserved transmembrane protein, similar to hypothetical
proteins from many bacteria e.g. AL0209|SC4H8_6 from
Streptomyces coelicolor (402 aa), FASTA scores: opt: 436,
E(): 1.7e-21,(27.2% identity in 349 aa overlap);
Z99117|BSUB0014_221 from Bacillus subtilis (353 aa), FASTA
scores: opt: 394,E(): 8.6e-19, (28.7% identity in 324 aa
overla)."
/db_xref="EnsemblGenomes-Gn:Rv0205"
/db_xref="EnsemblGenomes-Tr:CCP42933"
/db_xref="GOA:P9WFM5"
/db_xref="InterPro:IPR002549"
/db_xref="UniProtKB/Swiss-Prot:P9WFM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42933.1"
/translation="MSASLDDASVAPLVRKTAAWAWRFLVILAAMVALLWVLNKFEVI
VVPVLLALMLSALLVPPVDWLDSRGLPHAVAVTLVLLSGFAVLGGILTFVVSQFIAGL
PHLVTEVERSIDSARRWLIEGPAHLRGEQIDNAGNAAIEALRNNQAKLTSGALSTAAT
ITELVTAAVLVLFTLIFFLYGGRSIWQYVTKAFPASVRDRVRAAGRAGYASLIGYARA
TFLVALTDAAGVGAGLAVMGVPLALPLASLVFFGAFIPLIGAVVAGFLAVVVALLAKG
IGYALITVGLLIAVNQLEAHLLQPLVMGRAVSIHPLAVVLAIAAGGVLAGVVGALLAV
PTVAFFNNAVQVLLGGNPFADVADVSSDHLTEV"
gene complement(244484..247318)
/gene="mmpL3"
/locus_tag="Rv0206c"
CDS complement(244484..247318)
/codon_start=1
/transl_table=11
/gene="mmpL3"
/locus_tag="Rv0206c"
/product="Possible conserved transmembrane transport
protein MmpL3"
/note="Rv0206c, (MTV033.14c, MTCY08D5.01c), len: 944 aa.
Possible mmpL3, conserved transmembrane transport protein
(see Tekaia et al., 1999), equivalent to
Z95398|MLCL622.18c from Mycobacterium leprae (955 aa),
FASTA scores: opt: 806,E(): 1.8e-21, (57.2% identity in
243 aa overlap). Member of RND superfamily, similar to
others. Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv0206c"
/db_xref="EnsemblGenomes-Tr:CCP42934"
/db_xref="GOA:P9WJV5"
/db_xref="InterPro:IPR000731"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJV5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42934.1"
/translation="MFAWWGRTVYRYRFIVIGVMVALCLGGGVFGLSLGKHVTQSGFY
DDGSQSVQASVLGDQVYGRDRSGHIVAIFQAPAGKTVDDPAWSKKVVDELNRFQQDHP
DQVLGWAGYLRASQATGMATADKKYTFVSIPLKGDDDDTILNNYKAIAPDLQRLDGGT
VKLAGLQPVAEALTGTIATDQRRMEVLALPLVAVVLFFVFGGVIAAGLPVMVGGLCIA
GALGIMRFLAIFGPVHYFAQPVVSLIGLGIAIDYGLFIVSRFREEIAEGYDTETAVRR
TVITAGRTVTFSAVLIVASAIGLLLFPQGFLKSLTYATIASVMLSAILSITVLPACLG
ILGKHVDALGVRTLFRVPFLANWKISAAYLNWLADRLQRTKTREEVEAGFWGKLVNRV
MKRPVLFAAPIVIIMILLIIPVGKLSLGGISEKYLPPTNSVRQAQEEFDKLFPGYRTN
PLTLVIQTSNHQPVTDAQIADIRSKAMAIGGFIEPDNDPANMWQERAYAVGASKDPSV
RVLQNGLINPADASKKLTELRAITPPKGITVLVGGTPALELDSIHGLFAKMPLMVVIL
LTTTIVLMFLAFGSVVLPIKATLMSALTLGSTMGILTWIFVDGHFSKWLNFTPTPLTA
PVIGLIIALVFGLSTDYEVFLVSRMVEARERGMSTQEAIRIGTAATGRIITAAALIVA
VVAGAFVFSDLVMMKYLAFGLMAALLLDATVVRMFLVPSVMKLLGDDCWWAPRWARRL
QTRIGLGEIHLPDERKRPVSNGRPARPPVTAGLVAARAAGDPRPPHDPTHPLAESPRP
ARSSPASSPELTPALEATAAPAAPSGASTTRMQIGSSTEPPTTRLAAAGRSVQSPAST
PPPTPTPPSAPSAGQTRAMPLAANRSTDAAGDPAEPTAALPIIRSDGDDSEAATEQLN
ARGTSDKTRQRRRGGGALSAQDLLRREGRL"
gene complement(247384..248112)
/locus_tag="Rv0207c"
CDS complement(247384..248112)
/codon_start=1
/transl_table=11
/locus_tag="Rv0207c"
/product="Conserved hypothetical protein"
/note="Rv0207c, (MTCY08D5.02c), len: 242 aa. Conserved
hypothetical protein, equivalent to Z95398|MLCL622_19 from
Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8
identity in 199 aa overlap). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0207c"
/db_xref="EnsemblGenomes-Tr:CCP42935"
/db_xref="GOA:P96389"
/db_xref="InterPro:IPR021139"
/db_xref="UniProtKB/TrEMBL:P96389"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42935.1"
/translation="MSLTEDVTSQTSESLARHSVLAEDLSQDGLTSLGAPGARVLLVW
DAPNLDMGLGSILGRRPTALERPRFDALGRWLLARTAEIVAGRPGISTEPEATVFTNI
APGSAEVVRPWVDALRNVGFAVFAKPKVDEDSDVDRDMLAHIDERYREGLAALVVASA
DGQAFRQPLEAVARSGTPVQVLGFREHASWALASDTLEFVDLEDIAGVFREPLPRIGL
DSLPEQGAWLQPFRPLSSLLTSRV"
gene complement(248115..248906)
/locus_tag="Rv0208c"
CDS complement(248115..248906)
/codon_start=1
/transl_table=11
/locus_tag="Rv0208c"
/product="Hypothetical methlytransferase (methylase)"
/note="Rv0208c, (MTCY08D5.03c), len: 263 aa. Hypothetical
methyltransferase, equivalent to Z95398|MLCL622_20 from
Mycobacterium leprae (279 aa), FASTA score: (64.2%
identity in 246 aa overlaps). Also similar to others e.g.
10178368|CAC08407.1|AL392177|Q9F305|MT04_STRCO|SCD17A.03c
hypothetical methlytransferase from Streptomyces
coelicolor (271 aa). Could start at aa 7."
/db_xref="EnsemblGenomes-Gn:Rv0208c"
/db_xref="EnsemblGenomes-Tr:CCP42936"
/db_xref="GOA:P9WFY9"
/db_xref="InterPro:IPR003358"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFY9"
/protein_id="CCP42936.1"
/translation="MVHHGQMHAQPGVGLRPDTPVASGQLPSTSIRSRRSGISKAQRE
TWERLWPELGLLALPQSPRGTPVDTRAWFGRDAPVVLEIGSGSGTSTLAMAKAEPHVD
VIAVDVYRRGLAQLLCAIDKVGSDGINIRLILGNAVDVLQHLIAPDSLCGVRVFFPDP
WPKARHHKRRLLQPATMALIADRLVPSGVLHAATDHPGYAEHIAAAGDAEPRLVRVDP
DTELLPISVVRPATKYERKAQLGGGAVIELLWKKHGCSERDLKIR"
gene 249038..250123
/locus_tag="Rv0209"
CDS 249038..250123
/codon_start=1
/transl_table=11
/locus_tag="Rv0209"
/product="Hypothetical protein"
/note="Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0209"
/db_xref="EnsemblGenomes-Tr:CCP42937"
/db_xref="GOA:P96391"
/db_xref="UniProtKB/TrEMBL:P96391"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42937.1"
/translation="MRGQGHQIFVDELARFATSSADQRVVAIAQRAAEPLRVAVRGRP
GVGCRTVARALQGAGSSSGMTVTPQARAADSDVDLVVYVTVEVVKPEDREAIAATRRP
VVAVLNKADLAGPLSGAGPIVMAQARCAQFSTLLGVPMESMIGLLAVAALDDLDDTLR
AVLRALAAHPDGFDALDRAVAGFLAAALPVPTEVRLRLLDTLDLFGIALGMAAFRPGR
PSRTPAQLRTLLRRVSGVDAVIDKVTAAGSEVRYRRLLDAVAELEALAAQAKEIGGPI
GEFLRDDDTVLARMAAAVDVALAVGLDVGPLDDPAAHLPRAVRWHRYSLDNGDMHRTC
GADIARGSLRLWSLAGGMPLHRYRKSS"
gene 250120..251598
/locus_tag="Rv0210"
CDS 250120..251598
/codon_start=1
/transl_table=11
/locus_tag="Rv0210"
/product="Hypothetical protein"
/note="Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical
unknown protein. Possibly membrane protein; has
hydrophobic stretches around aa 333 - 381."
/db_xref="EnsemblGenomes-Gn:Rv0210"
/db_xref="EnsemblGenomes-Tr:CCP42938"
/db_xref="GOA:P96392"
/db_xref="UniProtKB/TrEMBL:P96392"
/protein_id="CCP42938.1"
/translation="MIRAASDDPAGVDELVAAIAPGLAGLGLPVINRREVVLVTGPWL
AGVSGVRAALAERLPQRRFVETAELGPGDAPVAVVFVVSAATALTESDCVLLDTAAEH
TDAVVAVVSKIDVHRGWRDVLTSNRDRLAARASRYARVPWVGAAAAPELGEPYLDDLV
AAIQKQLADPAVARRNMLRAWESRLLMVARRFDGDAQSAGRRARVDALRQQRRTVLRQ
GRQSKSEHTIALRAQIQHARVKLSYFARNRCSLLRVELQEHVAGLSRKDIARFAAYTR
GRVQEVVAEVGEGAVAHLADVAQLLGVPVQPPVLENLPAVLPTVVAPPLTSRRLEIRL
TTLLGAGFGLGIALTLSRLVAGLTPGLAASGMVAGVAIGLAVTAWVVNARALLHDRVV
VDRWTGEVTASLRSVVEQLVATRVVAVETLLSTAISERDDAENARVADQVSIIDGELR
EHAVAAARAAALRDREMPAVRAALEAVRAELGEPGAPTTGLF"
gene 251782..253602
/gene="pckA"
/gene_synonym="pck1"
/gene_synonym="pckG"
/locus_tag="Rv0211"
CDS 251782..253602
/codon_start=1
/transl_table=11
/gene="pckA"
/gene_synonym="pck1"
/gene_synonym="pckG"
/locus_tag="Rv0211"
/product="Probable iron-regulated phosphoenolpyruvate
carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase)
(PEPCK)(pep carboxykinase)"
/note="Rv0211, (MTCY08D5.06), len: 606 aa. Probable pckA
(alternate gene names: pckG and pck1), iron-regulated
phosphoenolpyruvate carboxykinase [GTP], equivalent to
Z95398|MLCL622_21 probable phosphoenolpyruvate
carboxykinase from Mycobacterium leprae (609 aa), FASTA
score: (86.1% identity in 605 aa overlap). Also highly
similar to others e.g. PPCK_NEOFR|P22130
phosphoenolpyruvate carboxykinase [GTP] (608 aa), FASTA
scores: opt: 2287, E(): 0, (55.9% identity in 598 aa
overlap). Contains PS00505 Phosphoenolpyruvate
carboxykinase (GTP) signature. Belongs to the
phosphoenolpyruvate carboxykinase [GTP] family."
/db_xref="EnsemblGenomes-Gn:Rv0211"
/db_xref="EnsemblGenomes-Tr:CCP42939"
/db_xref="GOA:P9WIH3"
/db_xref="InterPro:IPR008209"
/db_xref="InterPro:IPR008210"
/db_xref="InterPro:IPR013035"
/db_xref="InterPro:IPR018091"
/db_xref="InterPro:IPR035077"
/db_xref="InterPro:IPR035078"
/db_xref="PDB:4R43"
/db_xref="PDB:4RCG"
/db_xref="UniProtKB/Swiss-Prot:P9WIH3"
/inference="protein motif:PROSITE:PS00505"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42939.1"
/translation="MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEE
FQRLCDQLVEAGTFIRLNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNW
MDPGEMRSIMKDLYRGCMRGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMT
RMGKAALEKMGDDGFFVKALHSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGS
GYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKT
NLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMR
TIAAGNTVFTNVALTDDGDVWWEGLEGDPQHLIDWKGNDWYFRETETNAAHPNSRYCT
PMSQCPILAPEWDDPQGVPISGILFGGRRKTTVPLVTEARDWQHGVFIGATLGSEQTA
AAEGKVGNVRRDPMAMLPFLGYNVGDYFQHWINLGKHADESKLPKVFFVNWFRRGDDG
RFLWPGFGENSRVLKWIVDRIEHKAGGATTPIGTVPAVEDLDLDGLDVDAADVAAALA
VDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDALKERLG"
gene complement(253669..254640)
/gene="nadR"
/gene_synonym="nadI"
/locus_tag="Rv0212c"
CDS complement(253669..254640)
/codon_start=1
/transl_table=11
/gene="nadR"
/gene_synonym="nadI"
/locus_tag="Rv0212c"
/product="Possible transcriptional regulatory protein NadR
(probably AsnC-family)"
/note="Rv0212c, (MTCY08D5.07c), len: 323 aa. Possible nadR
(alternate gene name: nadI), transcriptional
regulator,similar to others e.g. NADR_ECOLI|P27278
transcriptional regulator from Escherichia coli (410 aa),
FASTA scores: opt: 377, E (): 1e-17, (31.1% identity in
347 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0212c"
/db_xref="EnsemblGenomes-Tr:CCP42940"
/db_xref="GOA:P96394"
/db_xref="InterPro:IPR004821"
/db_xref="InterPro:IPR006417"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR016429"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR038727"
/db_xref="InterPro:IPR041749"
/db_xref="UniProtKB/TrEMBL:P96394"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP42940.1"
/translation="MTHGMVLGKFMPPHAGHVYLCEFARRWVDELTIVVGSTAAEPIP
GAQRVAWMRELFPFDRVVHLANENPQRPWEHPDFWDIWKASLQGVLATRPDFVFGAEP
YNADFAQVLGARFVAVDHGRTVVPVTATDIRADPLGHWQHIPRCVRPAFVKRVSIIGP
ESTGKTTLAQAVAEKLRTKWVPERAKMLRELNGGSLIGLEWAEIVRGQIASEEALARD
ADRVLICDTDPLATTVWAEFLAGGCPQELRDLARRPYDLTLLTTPDVPWDADDGRCVP
GARGTFFARCEQALRAAGRSFVVITGGWEERLSVSLRAVEELVRARR"
gene complement(254637..255950)
/locus_tag="Rv0213c"
CDS complement(254637..255950)
/codon_start=1
/transl_table=11
/locus_tag="Rv0213c"
/product="Possible methyltransferase (methylase)"
/note="Rv0213c, (MTCY08D5.08c), len: 437 aa. Possible
methyltransferase, weakly similar to others
methyltransferases e.g. AF127374_30|LINA from Streptomyces
lavendulae (611 aa), FASTA scores: opt: 400, E():
8.1e-19,(27.3% identity in 388 aa overlap); Q50258
fortimicin kl1 methyltransferase (553 aa), FASTA scores:
opt: 267, E(): 1.2e-13, (29.3% identity in 351 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0213c"
/db_xref="EnsemblGenomes-Tr:CCP42941"
/db_xref="GOA:P96395"
/db_xref="InterPro:IPR006158"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR023404"
/db_xref="InterPro:IPR034466"
/db_xref="UniProtKB/TrEMBL:P96395"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42941.1"
/translation="MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTP
RLVGFSCIDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD
GEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVL
ADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNF
LSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGL
RRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDE
LRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEAS
RVYADVVAKVAPDVGISFDEAEAYFLSRLDEWENVIAGRIAEATS"
gene 256064..257677
/gene="fadD4"
/locus_tag="Rv0214"
CDS 256064..257677
/codon_start=1
/transl_table=11
/gene="fadD4"
/locus_tag="Rv0214"
/product="Probable fatty-acid-CoA ligase FadD4
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0214, (MTCY08D5.09), len: 537 aa. Probable
fadD4,fatty-acid-CoA synthetase, similar to many e.g.
4CL_PINTA|P41636 4-coumarate--CoA ligase (537 aa), FASTA
scores: opt: 622, E(): 1e-31, (30.0% identity in 514 aa
overlap). Also similar to others from Mycobacterium
tuberculosis e.g. MTCY6A4.14 FASTA score: (30.7% identity
in 501 aa overlap); MTCY493_27, MTCY07A7_11, MTCI28_6.
Contains PS00455 putative AMP-binding domain signature."
/db_xref="EnsemblGenomes-Gn:Rv0214"
/db_xref="EnsemblGenomes-Tr:CCP42942"
/db_xref="GOA:P96396"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:P96396"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42942.1"
/translation="MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKP
AVILYPSGTVISFDELEARANRLAHWFRQAGLREDDVVAILMENNEHVHAVMWAARRS
GLYYVPINTHLTASEAAYIVDNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAGG
GLVGWMTYPECVADQPDTPIEDEREGDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMM
PALLDFWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYR
VTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIHAAAPCPVQIKEQMIHWWGPIIDE
YYASSEASGSTLITAEDWLTHPGSVGKPIQGGVHIVGADGSELPPNQPGEIYFEGGYP
FEYLNDPAKTAASRNKHGWVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAEN
LLVAHPKVLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKC
PRSIAFEPQLPRTDTGKLYKSGLVEKYSV"
gene complement(257783..258856)
/gene="fadE3"
/locus_tag="Rv0215c"
CDS complement(257783..258856)
/codon_start=1
/transl_table=11
/gene="fadE3"
/locus_tag="Rv0215c"
/product="Probable acyl-CoA dehydrogenase FadE3"
/note="Rv0215c, (MTCY08D5.10c), len: 357 aa. Probable
fadE3, acyl- dehydrogenase, similar to many e.g.
ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis
(379 aa), FASTA scores: opt: 812, E(): 0, (39.5% identity
in 354 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0215c"
/db_xref="EnsemblGenomes-Tr:CCP42943"
/db_xref="GOA:P96397"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P96397"
/protein_id="CCP42943.1"
/translation="MRNELNDDEAMLVATVRAFIDRDVKPTVREVEHANSYPEAWIEQ
MKHIGIYGLAIDEQYGGSPVSMPCYVQVTQELARGWMSLAGAMGGHTVVAKLLTLFGT
EEQRRTYLPPMASGELRATMALTEPGGGSDLQNMSTTALADGPEGSAGLLINGCKTWI
SNARRSGLFAVLCKTDPNATPRHQGMSIVLVEPGPGLTVSRDLPKLGYKGVESCELSF
DNLRVPVSAILGGAMGQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQRESF
GRPIWQHQAVGNYLADMATKLTAARQLTRYAAERYDSGQRCDMEAGMAKLFASEVAME
IALNAVRIHGGYGYSTEYDVERR"
gene 258913..259926
/locus_tag="Rv0216"
CDS 258913..259926
/codon_start=1
/transl_table=11
/locus_tag="Rv0216"
/product="Double hotdog hydratase"
/note="Rv0216, (MTCY08D5.11), len: 337 aa. Double hotdog
R-specific hydratase of unknown function, shows no
activity for crotonyl-CoA, equivalent to Z95398|MLCL622_22
from Mycobacterium leprae (339 aa), FASTA scores: E(): 0,
(73.7 identity in 338 aa overlap). Shows structural
similarity to six others in Mycobacterium tuberculosis
(see Castell et al (2005) below). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0216"
/db_xref="EnsemblGenomes-Tr:CCP42944"
/db_xref="InterPro:IPR016790"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:I6Y340"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42944.1"
/translation="MASGYGGIRVGGPYFDDLSKGQVFDWAPGVTLSLGLAAAHQSIV
GNRLRLALDSDLCAAVTGMPGPLAHPGLVCDVAIGQSTLATQRVKANLFYRGLRFHRF
PAVGDTLYTRTEVVGLRANSPKPGRAPTGLAGLRMTTIDRTDRLVLDFYRCAMLPASP
DWKPGAVPGDDLSRIGADAPAPAADPTAHWDGAVFRKRVPGPHFDAGIAGAVLHSTAD
LVSGAPELARLTLNIAATHHDWRVSGRRLVYGGHTIGLALAQATRLLPNLATVLDWES
CDHTAPVHEGDTLYSELHIESAQAHADGGVLGLRSLVYAVSDSASEPDRQVLDWRFSA
LQF"
gene complement(259923..260831)
/gene="lipW"
/locus_tag="Rv0217c"
CDS complement(259923..260831)
/codon_start=1
/transl_table=11
/gene="lipW"
/locus_tag="Rv0217c"
/product="Possible esterase LipW"
/note="Rv0217c, (MTCY08D5.12c), len: 302 aa. Possible
esterase, showing similarity with others e.g.
EST_ACICA|P18773 esterase (303 aa), FASTA scores: opt:
320,E(): 3.2e-13, (29.2% identity in 274 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0217c"
/db_xref="EnsemblGenomes-Tr:CCP42945"
/db_xref="GOA:P96399"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P96399"
/protein_id="CCP42945.1"
/translation="MSGNEVHPDLRRIAVVTPRQLVGPRTLPVMRALIVVAGLRMSRT
PPDIEVLTLESGVGVRLYRPAGSNEPAPALLWIHAGGYVMGTAQQDDRLCLRFSSRLG
ITVASVDYRLAPENPYPAALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALAL
LARDRGGITPAFQLLVYPMLDDRPSIAPANPHYRLWNGRANRFGWRAYLGDADARVAV
PGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVEGAFHGFDRVAP
NVGVSQRFFTSQCNSLRAALALSNRT"
gene 260924..262252
/locus_tag="Rv0218"
CDS 260924..262252
/codon_start=1
/transl_table=11
/locus_tag="Rv0218"
/product="Probable conserved transmembrane protein"
/note="Rv0218, (MTCY08D5.13), len: 442 aa. Probable
conserved transmembrane protein, some similarity with
sulfite oxidases e.g. SUOX_HUMAN|P51687 sulfite oxidase
precursor (488 aa), FASTA scores: opt: 153, E():
0.0087,(28.6% identity in 161 aa overlap); and with some
nitrate reductases e.g. NIA_FUSOX|P39863 nitrate reductase
(NADPH) (905 aa), FASTA scores: opt: 143, E(): 0.06,
(29.3% identity in 92 aa overlap). Also similar to
BSUB0017_86 from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0218"
/db_xref="EnsemblGenomes-Tr:CCP42946"
/db_xref="GOA:P96400"
/db_xref="InterPro:IPR000572"
/db_xref="InterPro:IPR036374"
/db_xref="UniProtKB/TrEMBL:P96400"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42946.1"
/translation="MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRG
PWLTSVFGLVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVGWLRLPAFTWPTRPSWL
YRLTQGLHVGLGLVIIPVVLAKLWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQ
IVTGVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLLHIVVKIPHMVTGLRSIPMREVLG
TNVADTRAQPCDPDGLVSVNPGEATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKA
ALLLPRGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCGGPAEVVLDRATLAGLPQ
RTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAARSARVTSLQRGGAFGEAKLAAN
QIADPDALLALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHKR"
gene 262254..262802
/locus_tag="Rv0219"
CDS 262254..262802
/codon_start=1
/transl_table=11
/locus_tag="Rv0219"
/product="Probable conserved transmembrane protein"
/note="Rv0219, (MTCY08D5.14), len: 182 aa. Probable
conserved transmembrane protein, showing similarity with
CAB76992.1|AL159178 putative lipoprotein from Streptomyces
coelicolor (163 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0219"
/db_xref="EnsemblGenomes-Tr:CCP42947"
/db_xref="GOA:P96401"
/db_xref="UniProtKB/TrEMBL:P96401"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42947.1"
/translation="MFDIATRFKNSYGSGPLHLLAMVSGFALLGYIVATARPSALWNQ
ATWWQSIAVWFVAAVVAHDLLLYPLYALADRILARLVGRRDVSAPRRRPELPVRNYIR
IPALAAGLTLLVFLPGIIRQGAPTYLDATGQTQEPFLGRWLLLTAVAFGISAAAYAIR
LVVAHVRRRRAGCSRVDAIDEE"
gene 262812..264023
/gene="lipC"
/locus_tag="Rv0220"
CDS 262812..264023
/codon_start=1
/transl_table=11
/gene="lipC"
/locus_tag="Rv0220"
/product="Probable esterase LipC"
/note="Rv0220, (MTCY08D5.15), len: 403 aa. Probable
esterase, similar to others proteins and esterases from
various organisms and Mycobacterium tuberculosis e.g.
Q50681 (431 aa), FASTA scores: opt: 841, E(): 0, (38.2%
identity in 408 aa overlap); Rv1426c, Rv1399c, etc.
Contains PS00122 Carboxylesterases type-B serine active
site."
/db_xref="EnsemblGenomes-Gn:Rv0220"
/db_xref="EnsemblGenomes-Tr:CCP42948"
/db_xref="GOA:P96402"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR019826"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P96402"
/inference="protein motif:PROSITE:PS00122"
/protein_id="CCP42948.1"
/translation="MNQRRAAGSTGVAYIRWLLRARPADYMLALSVAGGSLPVVGKHL
KPLGGVTAIGVWGARHASDFLSATAKDLLTPGINEVRRRDRASTQEVSVAALRGIVSP
DDLAVEWPAPERTPPVCGALRHRRYVHRRRVLYGDDPAQLLDVWRRKDMPTKPAPVLI
FVPGGAWVHGSRAIQGYAVLSRLAAQGWVCLSIDYRVAPHHRWPRHILDVKTAIAWAR
ANVDKFGGDRNFIAVAGCSAGGHLSALAGLTANDPQYQAELPEGSDTSVDAVVGIYGR
YDWEDRSTPERARFVDFLERVVVQRTIDRHPEVFRDASPIQRVTRNAPPFLVIHGSRD
CVIPVEQARSFVERLRAVSRSQVGYLELPGAGHGFDLLDGARTGPTAHAIALFLNQVH
RSRAQFAKEVI"
gene 264067..265476
/locus_tag="Rv0221"
CDS 264067..265476
/codon_start=1
/transl_table=11
/locus_tag="Rv0221"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv0221, (MTCY08D5.16), len: 469 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004),
similar to other proteins from Mycobacterium tuberculosis
e.g. Q50680|Rv2285|MT2343|MTCY339.25c 47.7 kDa protein
(445 aa),FASTA scores: opt: 455, E(): 8.1e-23, (26.7%
identity in 461 aa overlap); Rv3740c, Rv3734c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0221"
/db_xref="EnsemblGenomes-Tr:CCP42949"
/db_xref="GOA:P9WKB7"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKB7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42949.1"
/translation="MKRLSGWDAVLLYSETPNVHMHTLKVAVIELDSDRQEFGVDAFR
EVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRPWRLRAPGGRRELDEA
VGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKIHHALADGVASANMMARGMDLLPG
PEVGRYVPDPAPTKRQLLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLSPALT
MPFTPPPTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALRTLLL
RYDGKAEPLLASVPVSYDFSPERISGNRFTGMLVALPADSDDPLQRVRVCHENAVSAK
ESHQLLGPELISRWAAYWPPAGAEALFRWLSERDGQNKVLNLNISNVPGPRERGRVGA
ALVTEIYSVGPLTAGSGLNITVWSYVDQLNISVLTDGSTVQDPHEVTAGMIADFIEIR
RAAGLSVELTVVESAMAQA"
gene 265507..266295
/gene="echA1"
/locus_tag="Rv0222"
CDS 265507..266295
/codon_start=1
/transl_table=11
/gene="echA1"
/locus_tag="Rv0222"
/product="Probable enoyl-CoA hydratase EchA1 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv0222, (MTCY08D5.17), len: 262 aa. Probable
echA1,enoyl-CoA hydratase, similar to others e.g.
AAC77915.1|AF063588 enoyl CoA hydratase from Rhodococcus
fascians (275 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0222"
/db_xref="EnsemblGenomes-Tr:CCP42950"
/db_xref="GOA:P96404"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="PDB:5KJP"
/db_xref="UniProtKB/TrEMBL:P96404"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42950.1"
/translation="MSSESDAANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGL
ADAMDQLDGDAGLSVAILTGGGGSFCAGMDLKAFARGENVVVEGRGLGFTERPPTKPL
IAAVEGYALAGGTELALAADLIVAARDSAFGIPEVKRGLVAGGGGLLRLPERIPYAIA
MELALTGDNLPAERAHELGLVNVLAEPGTALDAAIALAEKITANGPLAVVATKRIITE
SRGWSPDTMFAEQMKILVPVFTSNDAKEGAIAFAERRRPRWTGT"
gene complement(266301..267764)
/locus_tag="Rv0223c"
CDS complement(266301..267764)
/codon_start=1
/transl_table=11
/locus_tag="Rv0223c"
/product="Probable aldehyde dehydrogenase"
/note="Rv0223c, (MTCY08D5.18), len: 487 aa. Probable
aldehyde dehydrogenase, similar to others e.g.
A75608|6460525|AAF12231.1|AE001862_57 aldehyde
dehydrogenase from Deinococcus radiodurans strain R1 (495
aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent
from Gluconobacter oxydans (498 aa), FASTA scores: opt:
1157, E (): 0, (42.1% identity in 482 aa overlap); etc.
Also similar to Rv0768, Rv2858c, etc from Mycobacterium
tuberculosis. Contains PS00687 Aldehyde dehydrogenases
glutamic acid active site; and PS00070 Aldehyde
dehydrogenases cysteine active site. Belongs to the
aldehyde dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0223c"
/db_xref="EnsemblGenomes-Tr:CCP42951"
/db_xref="GOA:I6X8S7"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/TrEMBL:I6X8S7"
/inference="protein motif:PROSITE:PS00070"
/inference="protein motif:PROSITE:PS00687"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42951.1"
/translation="MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAA
AADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPP
TIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYGQSIVSREPVGVVGAIVAWNVPL
FLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQA
LTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMM
VFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEK
QRTRVEGYIAKGIEEGARLVCGGGRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPV
LAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYGINWYAFDPGS
PFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA"
gene complement(267863..268627)
/locus_tag="Rv0224c"
CDS complement(267863..268627)
/codon_start=1
/transl_table=11
/locus_tag="Rv0224c"
/product="Possible methyltransferase (methylase)"
/note="Rv0224c, (MTCY08D5.19c), len: 254 aa. Possible
methyltransferase, showing weak similarity with other
methyltransferases e.g. P74388 sterol-C-methyltransferase
(318 aa), FASTA scores: opt: 190, E(): 3.6e-05, (33.3%
identity in 114 aa overlap). Equivalent to
AL022486|MLCB1883_1 from Mycobacterium leprae (269
aa),FASTA scores: opt: 1456, E(): 0, (82.9% identity in
252 aa overlap). Also some similarity with MTCY21B4.22c
from Mycobacterium tuberculosis FASTA score: (30.1%
identity in 136 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0224c"
/db_xref="EnsemblGenomes-Tr:CCP42952"
/db_xref="GOA:P9WJZ9"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR026669"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WJZ9"
/protein_id="CCP42952.1"
/translation="MAVTDVFARRATLRRSLRLLADFRYEQRDPARFYRTLAADTAAM
IGDLWLATHSEPPVGRTLLDVGGGPGYFATAFSDAGVGYIGVEPDPDEMHAAGPAFTG
RPGMFVRASGMALPFADDSVDICLSSNVAEHVPRPWQLGTEMLRVTKPGGLVVLSYTV
WLGPFGGHEMGLSHYLGGARAAARYVRKHGHPAKNNYGSSLFAVSAAEGLRWAAGTGA
ALAVFPRYHPRWAWWLTSVPVLREFLVSNLVLVLTP"
gene 268663..269817
/locus_tag="Rv0225"
CDS 268663..269817
/codon_start=1
/transl_table=11
/locus_tag="Rv0225"
/product="Possible conserved protein"
/note="Rv0225, (MTCY08D5.20), len: 384 aa. Possible
conserved protein involved in LPS biosynthesis, similar to
O26275 LPS biosynthesis RFBU related protein (382
aa),FASTA scores: opt: 426, E(): 1.2e-20, (28.2% identity
in 394 aa overlap). Some similarity with Rv3032 from
Mycobacterium tuberculosis FASTA score: (31.6% identity in
228 aa overlap). Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0225"
/db_xref="EnsemblGenomes-Tr:CCP42953"
/db_xref="InterPro:IPR001296"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/TrEMBL:P96407"
/protein_id="CCP42953.1"
/translation="MSALRSVLLLCWRDIGHPQGGGSEAYLQRIGAQLAASGIAVTLR
TARYPGAPRHELVDGVRISRAGGRYSVYLWALLAMAAARCGLGPLRRVRPDVVVDTQN
GWPFVARLLYGRRSLVLVHHCHREQWPVAGRMMGRLGWYVESMLSPRLHRRNQYVTVS
LPSARDLIALGVDSERIAVVRNGLDEAPSPTLSGPRAPTPRVVVLSRLVPHKQIEDAL
AAVAELQPRIPGLHLDIVGGGWWRQRLVDHVHRLDIADAVTFHGHVDDVTKHHVLQSS
WVHLLPSRKEGWGLAVIEAAQHGVPTIGYRSSGGLADSIVDGVTGILVDDRAELVAWL
EQLLSDSVLRDQLGAKAQARSGEFSWRQSAEALRSVLEAVQASRFVSGVV"
gene complement(269834..271564)
/locus_tag="Rv0226c"
CDS complement(269834..271564)
/codon_start=1
/transl_table=11
/locus_tag="Rv0226c"
/product="Probable conserved transmembrane protein"
/note="Rv0226c, (MTCY08D5.21c), len: 576 aa. Probable
conserved transmembrane protein, equivalent, except in
N-terminal part, to AC32114.1|AL583926 conserved membrane
protein from Mycobacterium leprae (600 aa), FASTA scores:
opt: 2086, E(): 0, (70.3% identity in 579 aa overlap).
Also similar to AL021411|SC7H1_20 from Streptomyces
coelicolor (483 aa), FASTA scores: opt: 180, E(): 0.00028,
(26.5 identity in 388 aa overlap). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0226c"
/db_xref="EnsemblGenomes-Tr:CCP42954"
/db_xref="GOA:P96408"
/db_xref="UniProtKB/TrEMBL:P96408"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42954.1"
/translation="MRWFRPGYALVLVLLLAAPLLRPGYLLLRDAVSTPRSYVSANAL
GLTSAPRATPQDFAVALASHLVDGGVVVKALLLLGLWLAGWGAARLVATALPAAGAAG
QFVAITLAIWNPYVAERLLQGHWSLLVGYGCLPWVATAMLTMRTTVGAGWFGLFGLAF
WVALAGLTPSGLLLAATVAVVCVAMPGAGRPRWQCGVAALGSALVGALPWLTASALGS
SLTSHTAANQLGVTAFAPRAEPGLGTLGSLASLGGIWNGEAVPSSRTTLFAVASAVVL
LAMVAIGLPTVARRPVAVPLLTLAAVSVMVPAVLATGPGLHALRVVVDAAPGLGVLRD
GQKWVALAVPGYTLSGAGTVLTLRRWLRPATAAVVCCLALVLTLPDLAWGVWGKVAPV
HYPSGWAAVAAAINADPRTVAVLPAGTMRRFSWSGSAPVLDPLPRWVRADVLTTGDLV
ISGVTVPGEDAHARAVQELLLTGPHPSTLAAAGVGWLVVESDSAGDMGAAARTLGRLA
AAHRDDELALYRVGGQTSGASSARLKATMLAHWAWLSMLLVGGAGAAGYWVRRHLHHC
EDTPASRAQD"
gene complement(271574..272839)
/locus_tag="Rv0227c"
CDS complement(271574..272839)
/codon_start=1
/transl_table=11
/locus_tag="Rv0227c"
/product="Probable conserved membrane protein"
/note="Rv0227c, (MTCY08D5.22c), len: 421 aa. Possible
conserved membrane protein, equivalent to
AL022486|MLCB1883_4 from Mycobacterium leprae (448
aa),FASTA scores: opt: 2148, E(): 0, (76.6% identity in
423 aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0227c"
/db_xref="EnsemblGenomes-Tr:CCP42955"
/db_xref="GOA:P96409"
/db_xref="InterPro:IPR021424"
/db_xref="UniProtKB/TrEMBL:P96409"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42955.1"
/translation="MLRFAACGAIGLGAALLIAALLLSTYTTSRIAEIPLDIDATLIS
DGTGTALDSASLATEHIVVNQDVPLVSQQQVTVESPANADVVTLQVGSSLRRTDKQKD
SGLLLAIVDTVTLNRKTAMAVSDDTHTGGAVQKPRGLNDENPPTAIPLRHDGLSYRFP
FHTEKKTYPYFDPIAQKAFDANYEGEEDVNGLTTYRFTQNVGYTPEGKLVAPLKYPSL
YAGDEDGKVTTSAAMWGLPGDPNEQITMTRYYAAQRTFWVDPVSGTIVKETERANHYF
ARDPLKPEVTFADYQVTSTEETVESQVNAARDERDRLALWSRVLPITFTAAGLVALVG
GGLFASFSLRTEGALMAASGDRDDHDYRRGGFEEPVPGAEAETEKLPTQRPDFPREPS
GSDPPRLGSAQPPPPPDAGHPDPGPPERR"
repeat_region complement(272855..272955)
/note="101 bp Mycobacterial Interspersed Repetitive
Unit,class III"
gene 273055..274278
/locus_tag="Rv0228"
CDS 273055..274278
/codon_start=1
/transl_table=11
/locus_tag="Rv0228"
/product="Probable integral membrane acyltransferase"
/note="Rv0228, (MTCY08D5.23), len: 407 aa. Probable
integral membrane acyltransferase, equivalent to
3063875|CAA18555.1|AL022486|T44870 acyltransferase from
Mycobacterium leprae (384 aa), FASTA scores: opt:
2004,E(): 0, (79.3% identity in 381 aa overlap). Also
similar to others e.g. Q11064 probable acyltransferase
CY50.28C (383 aa), FASTA scores: opt: 372, E(): 2.6e-16,
(35.9% identity in 359 aa overlap); Q00718|MDMB_STRMY
acyltransferase. Very similar to Rv0111, Rv1254, etc from
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0228"
/db_xref="EnsemblGenomes-Tr:CCP42956"
/db_xref="GOA:P96410"
/db_xref="InterPro:IPR002656"
/db_xref="UniProtKB/TrEMBL:P96410"
/protein_id="CCP42956.1"
/translation="MGPADESGAPIRPQTPHRHTVLVTNGQVVGGTRGFLPAVEGMRA
CAAVGVVVTHVAFQTGHSSGVGGRLFGRFDLAVAVFFAVSGFLLWRGHAAAARDLRSH
PRTGPYLRSRVARIMPAYVVAVVVILSLLPDADHASLTVWLANLTLTQIYVPLTLTGG
LTQMWSLSVEVAFYAALPVLALLGRRIPVGARVPAIAALAALSWAWGWLPLDAGSGIN
PLTWPPAFFSWFAAGMLLAEWAYSPVGLPHRWARRRVAMAVTALLGYLVAASPLAGPE
GLVPGTAAQFAVKTAMGSLVAFALVAPLVLDRPDTSHRLLGSPAMVTLGRWSYGLFIW
HLAALAMVFPVIGAFPFTGRMPTVLVLTLIFGFAIAAVSYALVESPCREALRRWERRN
EPISVGELQADAIAP"
gene complement(274306..274986)
/locus_tag="Rv0229c"
CDS complement(274306..274986)
/codon_start=1
/transl_table=11
/locus_tag="Rv0229c"
/product="Possible conserved membrane protein with PIN
domain"
/note="Rv0229c, (MTCY08D5.24c), len: 226 aa. Possible
conserved membrane protein with PIN domain in C-terminal
half, similar to several others from Mycobacterium
tuberculosis. Has some similarity with Rv2757c|D70880 from
Mycobacterium tuberculosis (138 aa). (See Arcus et
al.,2005). FASTA scores: E(): 1e-15, (45.3% identity in
137 aa overlap), and Rv0301, Rv2546, etc. Also some
similarity with Q48177 virulence associated protein C (132
aa), FASTA scores: opt: 101, E(): 0.6, (24.3% identity in
136 aa overlap). Contains PS00626 Regulator of chromosome
condensation (RCC1) signature 2."
/db_xref="EnsemblGenomes-Gn:Rv0229c"
/db_xref="EnsemblGenomes-Tr:CCP42957"
/db_xref="GOA:L0T5V6"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:L0T5V6"
/inference="protein motif:PROSITE:PS00626"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42957.1"
/translation="MRQPRRANAMGLALCIYIGSLLIYTPIHGETSRRHRRAGFKHGS
YRIGHDDDQRHRQRGPAASHVSASSTRRRRSRHAGRRTARGPRRSMALKYLLDTSVIK
RLSRPAVRRAVEPLAEAGAVARTQITDLEVGYSARNETEWQRLMVALSAFDLIESTAS
HHRRALGIQRLLAARSQRGRKIPDLLIAAAGEEHGLVVLHYDADFDLIAAVTGQPCQW
IVPAGTID"
gene complement(274983..275963)
/gene="php"
/locus_tag="Rv0230c"
CDS complement(274983..275963)
/codon_start=1
/transl_table=11
/gene="php"
/locus_tag="Rv0230c"
/product="Probable phosphotriesterase Php (parathion
hydrolase) (PTE) (aryldialkylphosphatase) (paraoxonase)
(a-esterase) (aryltriphosphatase) (paraoxon hydrolase)"
/note="Rv0230c, (MTCY08D5.26c), len: 326 aa. Probable
php,phosphotriesterase, similar to others e.g.
AAK42653.1|AE006849 putative aryldialkylphosphatase
(phosphotriesterase) (paraoxonase) from Sulfolobus
solfataricus (314 aa); PHP_ECOLI|P45548 phosphotriesterase
homology protein from Escherichia coli (292 aa), FASTA
scores: opt: 408, E(): 7.1e-20, (31.1% identity in 305 aa
overlap); OPD_FLASP|P16648 parathion hydrolase precursor
(365 aa), FASTA scores: opt: 319, E(): 5.1e-14, (34.5%
identity in 333 aa overlap); etc. Belongs to the
phosphotriesterase family. Cofactor: contains 2 moles of
zinc per subunit."
/db_xref="EnsemblGenomes-Gn:Rv0230c"
/db_xref="EnsemblGenomes-Tr:CCP42958"
/db_xref="GOA:P9WHN9"
/db_xref="InterPro:IPR001559"
/db_xref="InterPro:IPR017947"
/db_xref="InterPro:IPR032466"
/db_xref="PDB:4IF2"
/db_xref="UniProtKB/Swiss-Prot:P9WHN9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42958.1"
/translation="MPELNTARGPIDTADLGVTLMHEHVFIMTTEIAQNYPEAWGDED
KRVAGAIARLGELKARGVDTIVDLTVIGLGRYIPRIARVAAATELNIVVATGLYTYND
VPFYFHYLGPGAQLDGPEIMTDMFVRDIEHGIADTGIKAGILKCATDEPGLTPGVERV
LRAVAQAHKRTGAPISTHTHAGLRRGLDQQRIFAEEGVDLSRVVIGHCGDSTDVGYLE
ELIAAGSYLGMDRFGVDVISPFQDRVNIVARMCERGHADKMVLSHDACCYFDALPEEL
VPVAMPNWHYLHIHNDVIPALKQHGVTDEQLHTMLVDNPRRIFERQGGYQ"
gene 276058..277764
/gene="fadE4"
/locus_tag="Rv0231"
CDS 276058..277764
/codon_start=1
/transl_table=11
/gene="fadE4"
/locus_tag="Rv0231"
/product="Probable acyl-CoA dehydrogenase FadE4"
/note="Rv0231, (MTCY08D5.27), len: 568 aa. Probable
fadE4,acyl-CoA dehydrogenase, similar to many e.g. O29752
acyl-CoA dehydrogenase (ACD-3) from Archaeoglobus fulgidus
(576 aa), FASTA scores: opt: 1788, E(): 0, (51.0% identity
in 577 aa overlap); ACDB_BACSU|P45857 acyl-CoA
dehydrogenase from Bacillus subtilis (379 aa), FASTA
scores: opt: 232, E(): 2.2e- 08, (21.6% identity in 291 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0231"
/db_xref="EnsemblGenomes-Tr:CCP42959"
/db_xref="GOA:P96414"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P96414"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42959.1"
/translation="MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHDDHERI
WYSDFLDFVGRERIFASLLTPASYGADDCRWDTYRISEFAEIMGFYGLSYWYPFQVTA
LGLGPIWMSANEDAKRKAAAGLEAGEVFAFGLSEQTHGADVYQTDMILTPSDGGWTAN
GEKYYIGNANVARMVSTFGKIAGTPESQEYVFFVADSQHERYDLIKNVVNSQNYVANY
ALRDYPVTEADILHRGAEAFHAALNTVNVCKYNLGWGAIGMCTHALYESVTHAANRHL
YGTVVTDFSHVRRLLTDAYVRLIAMKLVASRASDYMRSASAADRRYLLYSPLTKAKVT
SEGERVITALWDVIAAKGVEKDTFFETVAREIGLLPRLEGTVHINIGLLGKFMPNYLF
APDSTLPVIPRRDDAADDAFLFAQGPTGGLGKVRFHDWRASFDTCAHLPNVALLREQV
DVFAELLASATPDAAQQKDIDFAFGVGQLFANVPYAQLILEEARLSGVDEALIDEIFG
VLVRDFNTHAVELHGRSATTAEQARFAMRMVRRPVHDPARYDQIWKDHVLALNGAYQM
AP"
gene 277899..278588
/locus_tag="Rv0232"
CDS 277899..278588
/codon_start=1
/transl_table=11
/locus_tag="Rv0232"
/product="Probable transcriptional regulatory protein
(probably TetR/AcrR-family)"
/note="Rv0232, (MTCY08D5.28), len: 229 aa. Probable
transcriptional regulatory protein, TetR/AcrR
family,similar to others e.g. YIXD_BACSU|P32398
hypothetical transcriptional regulator (191 aa), FASTA
scores: opt: 149,E(): 0.0014, (21.5% identity in 158 aa
overlap). Also similar to MTV030_11 from Mycobacterium
tuberculosis. Contains PS01081 Bacterial regulatory
proteins, TetR family signature, and probable helix-turn
helix motif from aa 33-54 (Score 1142, +3.08 SD). Belongs
to the TetR/AcrR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv0232"
/db_xref="EnsemblGenomes-Tr:CCP42960"
/db_xref="GOA:P96415"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:P96415"
/inference="protein motif:PROSITE:PS01081"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42960.1"
/translation="MPTVTWARVDPARRAAVVEAAEAEFGAHGFSRGSLNVIARRAGV
AKGSLFQYFADKRDLYAFIADIASQRVRSYMEDLIRELDPNRPFFEFLTDLLDGWVAY
FAEHPRERALHAAATLEVDTDARISVRSVLHRHYLDVLRPLVRDAHARGDLRADSDTG
ALMSLLLLIFPHLALAPYMRGLDPILGLDEPTPEQPALAVRRLVAVLAAAFDAQHPAT
NSAQTRSEEIT"
gene 278585..279529
/gene="nrdB"
/gene_synonym="rnrS"
/locus_tag="Rv0233"
CDS 278585..279529
/codon_start=1
/transl_table=11
/gene="nrdB"
/gene_synonym="rnrS"
/locus_tag="Rv0233"
/product="Ribonucleoside-diphosphate reductase (beta
chain) NrdB (ribonucleotide reductase small chain)"
/note="Rv0233, (MTCY08D5.29), len: 314 aa. nrdB (alternate
gene name: rnrS) ribonucleoside-diphosphate reductase,
beta chain, similar to others e.g. RIR2_SCHPO|P36603
ribonucleoside-diphosphate reductase (391 aa), FASTA
scores: opt: 168, E(): 0.00018, (26.1% identity in 199 aa
overlap); etc. Belongs to the ribonucleoside diphosphate
reductase small chain family. Cofactor: iron, manganese"
/db_xref="EnsemblGenomes-Gn:Rv0233"
/db_xref="EnsemblGenomes-Tr:CCP42961"
/db_xref="GOA:P9WH69"
/db_xref="InterPro:IPR000358"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012348"
/db_xref="InterPro:IPR033908"
/db_xref="PDB:3EE4"
/db_xref="PDB:4AC8"
/db_xref="UniProtKB/Swiss-Prot:P9WH69"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42961.1"
/translation="MTRTRSGSLAAGGLNWASLPLKLFAGGNAKFWHPADIDFTRDRA
DWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSAMRAEGRLADEMYLTQFAFEEA
KHTQVFRMWLDAVGISEDLHRYLDDLPAYRQIFYAELPECLNALSADPSPAAQVRASV
TYNHIVEGMLALTGYYAWHKICVERAILPGMQELVRRIGDDERRHMAWGTFTCRRHVA
ADDANWTVFETRMNELIPLALRLIEEGFALYGDQPPFDLSKDDFLQYSTDKGMRRFGT
ISNARGRPVAEIDVDYSPAQLEDTFADEDRRTLAAASA"
gene complement(279605..281140)
/gene="gabD1"
/gene_synonym="gabD2"
/locus_tag="Rv0234c"
CDS complement(279605..281140)
/codon_start=1
/transl_table=11
/gene="gabD1"
/gene_synonym="gabD2"
/locus_tag="Rv0234c"
/product="Succinate-semialdehyde dehydrogenase [NADP+]
dependent (SSDH) GabD1"
/note="Rv0234c, (MTCY08D5.30c), len: 511 aa.
gabD1,succinate-semialdehyde dehydrogenase [NADP+]
dependent,equivalent to AL022486|MLCB1883_6 probable
aldehyde dehydrogenase from Mycobacterium leprae (457 aa),
FASTA scores: opt: 2617, E(): 0, (85.7% identity in 455 aa
overlap). Also highly similar to Q55585|GABD|SLR0370
probable succinate-semialdehyde dehydrogenase from
Synechocystis sp. strain PCC 6803 (454 aa), FASTA scores:
opt: 1676, E(): 0, (55.8% identity in 455 aa overlap); and
similar to others e.g. GABD_ECOLI|P25526
succinate-semialdehyde dehydrogenase from Escherichia coli
(482 aa), FASTA scores: opt: 929, E(): 0, (36.5% identity
in 452 aa overlap); etc. Note that similar to other
cytosolic aldehyde dehydrogenases with EC number: 1.2.1.3.
Also similar to Rv0768|aldA semialdehyde dehydrogenase
from Mycobacterium tuberculosis (489 aa); and
gabD2|Rv1731|MTCY04C12.16 possible succinate-semialdehyde
dehydrogenase [NADP+] dependent from Mycobacterium
tuberculosis (518 aa). Contains PS00070 aldehyde
dehydrogenases cysteine active site. Belongs to the
aldehyde dehydrogenases family. Could start at different
site by homology. Note that previously known as gabD2."
/db_xref="EnsemblGenomes-Gn:Rv0234c"
/db_xref="EnsemblGenomes-Tr:CCP42962"
/db_xref="GOA:P9WNX9"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016160"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="UniProtKB/Swiss-Prot:P9WNX9"
/inference="protein motif:PROSITE:PS00070"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42962.1"
/translation="MRSVTCSATLVLPVIEPTPADRRPRHLLLGSAGHVSGRLDTGRF
VQTHPAKDVSVPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRA
RWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEP
ADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQ
CALYLADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAG
NEIKPTVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDD
FVDKFVARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLD
RPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGSNAWT
RDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSAHGIREFCNIKTV
WIA"
gene complement(281166..282614)
/locus_tag="Rv0235c"
CDS complement(281166..282614)
/codon_start=1
/transl_table=11
/locus_tag="Rv0235c"
/product="Probable conserved transmembrane protein"
/note="Rv0235c, (MTCY08D5.31c), len: 482 aa. Probable
conserved transmembrane protein, highly similar to
AL133278|CAB61913.1|SCM11_2 putative integral membrane
protein from Streptomyces coelicolor (470 aa), FASTA
scores: opt: 2116, E(): 0, (61.8% identity in 474 aa
overlap); and similar to hypothetical proteins from other
organisms e.g. Q13392|384D8_7 hypothetical protein (579
aa), FASTA scores: opt: 355, E(): 6.9e-17, (28.5% identity
in 569 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0235c"
/db_xref="EnsemblGenomes-Tr:CCP42963"
/db_xref="GOA:P96418"
/db_xref="InterPro:IPR009613"
/db_xref="UniProtKB/TrEMBL:P96418"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42963.1"
/translation="MGWFSAPEYWLGRLALERGTAIIYLIAFVAAAQQFRPLIGEHGM
LPVPRYLAGQSFWRTPSIFHFRYSDRVFAGVCWLGAVLSAAVVAGAASFVPLWATMLI
WLTLWVLYLSIVNVGQAWYSFGWESLLLETGFLMIFLGNERTAPPILTLLLARWLLFR
VEFGAGLIKMRGDSCWRSLTCLYYHHETQPMPGPLSWFFHHLPKPLHRIEVAGNHFAQ
LVVPFGLFTPQPAASIAAAIIVVTQLWLVASGNFSWLNWLTILLACSAIDTSSAAALL
PMPAQPALSAPPQWFAGLVVVFTAAVLLLSYWPARNLLSSHQRMNMSFNPFHLVNTYG
AFGSICRTRREVVIEGTDESPITEQTVWKAYEFKGKPGDPRRLPRQWAPYHLRLDWLM
WFAAISPGYALPWMTPFLNRLLRNDPATLKLLRHNPFPQSPPRYVRAQLYQYRFTTVA
ELRRDRAWWHRTLIGRYVPPMSLRKVASPPAD"
gene complement(282649..286851)
/gene="aftD"
/locus_tag="Rv0236c"
CDS complement(282649..286851)
/codon_start=1
/transl_table=11
/gene="aftD"
/locus_tag="Rv0236c"
/product="Possible arabinofuranosyltransferase AftD"
/note="Rv0236c, (MTV034.01c, MTV034.02c,
MTCY08D5.32c),len: 1400 aa. Possible aftD,
arabinofuranosyltransferase (See Skovierova et al., 2009).
Predicted to be in the GT-C superfamily of
glycosyltransferases (See Liu and Mushegian,2003).
Probable conserved transmembrane protein, equivalent to
AL022486|CAC32102.1|MLCB1883_7 possible integral membrane
protein from Mycobacterium leprae (1440 aa), FASTA scores:
opt: 7491, E(): 0, (78.8% identity in 1397 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0236c"
/db_xref="EnsemblGenomes-Tr:CCP42964"
/db_xref="GOA:P96419"
/db_xref="InterPro:IPR000421"
/db_xref="InterPro:IPR008979"
/db_xref="InterPro:IPR021798"
/db_xref="UniProtKB/Swiss-Prot:P96419"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42964.1"
/translation="MAPLSRKWLPVVGAVALALTFAQSPGQVSPDTKLDLTANPLRFL
ARATNLWNSDLPFGQAQNQAYGYLFPHGTFFVIGHLLGVPGWVTQRLWWAVLLTVGFW
GLLRVAEALGVGGPSSRVVGAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILAL
RGTSGRSVRALAAQAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRLWWRYTAWWL
LAMALATLWWVMALTQLHGVSPPFLDFIESSGVTTQWSSLVEVLRGTDSWTPFVAPNA
TAGAPLVTGSAAILGTCLVAAAGLAGLTSPAMPARGRLVTMLLVGVVLLAVGHRGGLA
SPVAHPVQAFLDAAGTPLRNVHKVGPVIRLPLVLGLAQLLSRVPLPGSAPRPAWLRAF
AHPERDKRVAVAVVALTALMVSTSLAWTGRVAPPGTFGALPQYWQEAADWLRTHHAAT
PTPGRVLVVPGAPFATQVWGTSHDEPLQVLGDGPWGVRDSIPLTPPQTIRALDSVQRL
FAAGRPSAGLADTLARQGISYVLVRNDLDPETSRSARPILLHRSIAGSPGLAKLAEFG
APVGPDPLAGFVNDSGLRPRYPAIEIYRVSAPANPGAPYFAATDQLARVDGGPEVLLR
LDERRRLQGQPPLGPVLMTADARAAGLPVPQVAVTDTPVARETDYGRVDHHSSAIRAP
GDARHTYNRVPDYPVPGAEPVVGGWTGGRITVSSSSADATAMPDVAPASAPAAAVDGD
PATAWVSNALQAAVGQWLQVDFDRPVTNAVVTLTPSATAVGAQVRRILIETVNGSTTL
RFDEAGKPLTAALPYGETPWVRFTAAATDDGSAGVQFGITDLAITQYDASGFAHPVQL
RHTVLVPGPPPGSAIAGWDLGSELLGRPGCAPGPDGVRCAASMALAPEEPANLSRTLT
VPRPVSVTPMVWVRPRQGPKLADLIAAPSTTRASGDSDLVDILGSAYAAADGDPATAW
TAPQRVVQHKTPPTLTLTLPRPTVVTGLRLAASRSMLPAHPTVVAINLGDGPQVRQLQ
VGELTTLWLHPRVTDTVSVSLLDWDDVIDRNALGFDQLKPPGLAEVVVLSAGGAPIAP
ADAARNRARALTVDCDHGPVVAVAGRFVHTSIRTTVGALLDGEPVAALPCEREPIALP
AGQQELLISPGAAFVVDGAQLSTPGAGLSSATVTSAETGAWGPTHREVRVPESATSRV
LVVPESINSGWVARTSTGARLTPIAVNGWQQAWVVPAGNPGTITLTFAPNSLYRASLA
IGLALLPLLALLAFWRTGRRQLADRPTPPWRPGAWAAAGVLAAGAVIASIAGVMVMGT
ALGVRYALRRRERLRDRVTVGLAAGGLILAGAALSRHPWRSVDGYAGNWASVQLLALI
SVSVVAASVVATSESRGQDRMQ"
gene complement(286898..287071)
/locus_tag="Rv0236A"
CDS complement(286898..287071)
/codon_start=1
/transl_table=11
/locus_tag="Rv0236A"
/product="Small secreted protein"
/note="Rv0236A, len: 57 aa. Small secreted protein. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0236A"
/db_xref="EnsemblGenomes-Tr:CCP42965"
/db_xref="InterPro:IPR022566"
/db_xref="UniProtKB/Swiss-Prot:P9WLB1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42965.1"
/translation="MNRIVAPAAASVVVGLLLGAAAIFGVTLMVQQDKKPPLPGGDPS
SSVLNRVEYGNRS"
gene 287186..288352
/gene="lpqI"
/locus_tag="Rv0237"
CDS 287186..288352
/codon_start=1
/transl_table=11
/gene="lpqI"
/locus_tag="Rv0237"
/product="Probable conserved lipoprotein LpqI"
/note="Rv0237, (MTV034.03), len: 388 aa. Probable
lpQI,conserved lipoprotein, equivalent to
AL022486|MLCB1883_8|T44873 probable secreted hydrolase
from Mycobacterium leprae (387 aa), FASTA scores: opt:
1831,E(): 0, (73.3% identity in 390 aa overlap). Also
similar to other lipoproteins and various hydrolases e.g.
P40406|2126897|YBBD_BACSU|I39839 hypothetical 70.6 KDA
lipoprotein from Bacillus subtilis (642 aa);
P48823|HEXA_ALTSO beta-hexosaminidase a precursor from
alteromonas SP. (598 aa), FASTA scores: opt: 415, E():
5.8e-17, (31.2% identity in 343 aa overlap);
PCC6803|P74340 beta-glucosidase from Synechocystis sp.
(538 aa), FASTA scores: opt: 414, E(): 6.1e-17, (30.6
identity in 320 aa overlap). Contains signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0237"
/db_xref="EnsemblGenomes-Tr:CCP42966"
/db_xref="GOA:L7N6B0"
/db_xref="InterPro:IPR001764"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR036962"
/db_xref="PDB:6GFV"
/db_xref="UniProtKB/Swiss-Prot:L7N6B0"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42966.1"
/translation="MAFPRTLAILAAAAALVVACSHGGTPTGSSTTSGASPATPVAVP
VPRSCAEPAGIPALLSPRDKLAQLLVVGVRDAADAQAVVTNYHVGGILIGSDTDLTIF
DGALAEIVAGGGPLPLAVSVDEEGGRVSRLRSLIGGTGPSARELAQTRTVQQVRDLAR
DRGRQMRKLGITIDFAPVVDVTDAPDDTVIGDRSFGSDPATVTAYAGAYAQGLRDAGV
LPVLKHFPGHGRGSGDSHNGGVTTPPLDDLVGDDLVPYRTLVTQAPVGVMVGHLQVPG
LTGSEPASLSKAAVNLLRTGTGYGAPPFDGPVFSDDLSGMAAISDRFGVSEAVLRTLQ
AGADIALWVTTKEVPAVLDRLEQALRAGELPMSAVDRSVVRVATMKGPNPGCGR"
gene 288428..289042
/locus_tag="Rv0238"
CDS 288428..289042
/codon_start=1
/transl_table=11
/locus_tag="Rv0238"
/product="Possible transcriptional regulatory protein
(probably TetR-family)"
/note="Rv0238, (MTV034.04), len: 204 aa. Possible
transcriptional regulatory protein, TetR family,
equivalent to AL022486|MLCB1883_9|T44874 probable
transcription regulator from Mycobacterium leprae (208
aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in
199 aa overlap). Also similar to others e.g.
CAB77290.1|AL160312 putative TetR-family regulatory
protein from Streptomyces coelicolor (240 aa). Also
similar to Mycobacterium tuberculosis proteins
Z95120|Rv3208 (228 aa), FASTA scores: opt: 266,E():
8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019
(197 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0238"
/db_xref="EnsemblGenomes-Tr:CCP42967"
/db_xref="GOA:O53661"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041490"
/db_xref="UniProtKB/TrEMBL:O53661"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42967.1"
/translation="MAGGTKRLPRAVREQQMLDAAVQMFSVNGYHETSMDAIAAEAQI
SKPMLYLYYGSKEDLFGACLNREMSRFIDALRSSINFDQSPKDLLRNTIVSFLRYIDA
NRASWIVMYTQATSSQAFAHTVREGREQIVQLVAELVRAGTRGPLTDAEIEMMAVALV
GAGEAVATRLGIGDTDVDEAAEMMINLFWLGLKGAPVDRLETGH"
gene 289104..289337
/gene="vapB24"
/locus_tag="Rv0239"
CDS 289104..289337
/codon_start=1
/transl_table=11
/gene="vapB24"
/locus_tag="Rv0239"
/product="Possible antitoxin VapB24"
/note="Rv0239, (MTV034.05), len: 77 aa. Possible
vapB24,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0240. Weakly similar to others e.g.
Rv1839c|Z83859|MTCY359_34 from Mycobacterium tuberculosis
(87 aa). See Arcus et al. 2005. FASTA scores: opt: 88,
E(): 5, (40.0% identity in 45 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0239"
/db_xref="EnsemblGenomes-Tr:CCP42968"
/db_xref="UniProtKB/Swiss-Prot:P9WJ41"
/protein_id="CCP42968.1"
/translation="MIRTQVQLPDELYRDAKRVAHEHEMTLAEVVRRGLEHMVRIYPR
RDAASDTWQPPTPRRLGPFRASEETWRELANEA"
gene 289345..289782
/gene="vapC24"
/locus_tag="Rv0240"
CDS 289345..289782
/codon_start=1
/transl_table=11
/gene="vapC24"
/locus_tag="Rv0240"
/product="Possible toxin VapC24. Contains PIN domain."
/note="Rv0240, (MTV034.06), len: 145 aa. Possible
vapC24,toxin, part of toxin-antitoxin (TA) operon with
Rv0239,contains PIN domain, weak similarity with Rv3697c
from Mycobacterium tuberculosis (145 aa). See Arcus et al.
2005. FASTA scores: opt: 145, E(): 7.6e-05, (28.0%
identity in 143 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0240"
/db_xref="EnsemblGenomes-Tr:CCP42969"
/db_xref="GOA:P9WF87"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42969.1"
/translation="MLSIDTNILLYAQNRDCPEHDAAAAFLVECAGRADVAVCELVLM
ELYQLLRNPTVVTRPLEGPEAAEVCQTFRRNRRWALLENAPVMNEVWVLAATPRIARR
RLFDARLALTLRHHGVDEFATRNINGFTDFGFSRVWDPITSDG"
gene complement(289812..290654)
/gene="htdX"
/locus_tag="Rv0241c"
CDS complement(289812..290654)
/codon_start=1
/transl_table=11
/gene="htdX"
/locus_tag="Rv0241c"
/product="Probable 3-hydroxyacyl-thioester dehydratase
HtdX"
/note="Rv0241c, (MTV034.07c), len: 280 aa. Probable
htdX,3-hydroxyacyl-thioester dehydratase (See Gurvitz et
al.,2009), highly similar to
MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical
protein from Mycobacterium leprae (280 aa), FASTA scores:
opt: 1564, E(): 0, (81.8% identity in 280 aa overlap); and
CAC32097.1|AL583926 conserved hypothetical protein from
Mycobacterium leprae (300 aa). Shows structural similarity
to six others in Mycobacterium tuberculosis (see Castell
et al (2005) below). Also similar to proteins from other
organisms e.g. CAB77291.1|AL160312 putative dehydratase
from Streptomyces coelicolor (291 aa); part of
BAA92930.1|AB032743 fatty acid synthetase beta subunit
from Pichia angusta (2060 aa). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0241c"
/db_xref="EnsemblGenomes-Tr:CCP42970"
/db_xref="GOA:O53664"
/db_xref="InterPro:IPR002539"
/db_xref="InterPro:IPR003965"
/db_xref="InterPro:IPR029069"
/db_xref="PDB:3WEW"
/db_xref="PDB:4OOB"
/db_xref="UniProtKB/TrEMBL:O53664"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42970.1"
/translation="MTQPSGLKNLLRAAAGALPVVPRTDQLPNRTVTVEELPIDPANV
AAYAAVTGLRYGNQVPLTYPFALTFPSVMSLVTGFDFPFAAMGAIHTENHITQYRPIA
VTDAVGVRVRAENLREHRRGLLVDLVTNVSVGNDVAWHQVTTFLHQQRTSLSGEPKPP
PQKKPKLPPPAAVLRITPAKIRRYAAVGGDHNPIHTNPIAAKLFGFPTVIAHGMFTAA
AVLANIEARFPDAVRYSVRFAKPVLLPATAGLYVAEGDGGWDLTLRNMAKGYPHLTAT
VRGL"
gene complement(290665..292029)
/gene="fabG4"
/locus_tag="Rv0242c"
CDS complement(290665..292029)
/codon_start=1
/transl_table=11
/gene="fabG4"
/locus_tag="Rv0242c"
/product="Probable 3-oxoacyl-[acyl-carrier protein]
reductase FabG4 (3-ketoacyl-acyl carrier protein
reductase)"
/note="Rv0242c, (MTV034.08c), len: 454 aa. Probable
fabG4,3-oxoacyl-[acyl-carrier protein] reductase,
equivalent to 3063883|CAA18568.1|AL022486|MLCB1883_13|T448
78 3-oxoacyl-[acyl-carrier protein] reductase homolog from
Mycobacterium leprae (454 aa), FASTA scores: opt:
2486,E(): 0, (84.8% identity in 454 aa overlap).
C-terminal part highly similar to many FabG proteins e.g.
U39441|VHU3944 1_2 from Vibrio harveyi (244 aa), FASTA
scores: opt: 562,E(): 3.4e-28, (40.2% identity in 241 aa
overlap); U91631|PAU91631_3 from Pseudomonas aeruginosa
(247 aa),FASTA scores: opt: 584, E(): 1.5e-29, (44.4%
identity in 241 aa overlap). Has N-terminal extension of
~200 aa and C-terminal part contains PS00061 Short-chain
dehydrogenases/reductases family signature. Belongs to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv0242c"
/db_xref="EnsemblGenomes-Tr:CCP42971"
/db_xref="GOA:I6Y778"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6Y778"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42971.1"
/translation="MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPL
TGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGL
HEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTAL
VYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIV
TGAARGIGATIAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDK
ISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNG
SIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGF
IETQMTAAIPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQA
MIGA"
gene 292171..293493
/gene="fadA2"
/locus_tag="Rv0243"
CDS 292171..293493
/codon_start=1
/transl_table=11
/gene="fadA2"
/locus_tag="Rv0243"
/product="Probable acetyl-CoA acyltransferase FadA2
(3-ketoacyl-CoA thiolase) (beta-ketothiolase)"
/note="Rv0243, (MTV034.09), len: 440 aa. Probable
fadA2,acetyl-CoA acyltransferase (3-acyl-CoA
thiolase),equivalent, but shorter 17 aa, to
AL022486|MLCB1883_14T44879 acetyltransferase from
Mycobacterium leprae (457 aa), FASTA scores: opt: 250
7,E(): 0, (87.6% identity in 435 aa overlap). Also highly
similar to many e.g. G83046|PA478 probable acyl-CoA
thiolase from Pseudomonas aeruginosa (425 aa);
AB77293.1|AL160312 putative ketoacyl CoA thiolase from
Streptomyces coelicolor (428 aa);
P76503|7449731|YFCY_ECOLI|D65007|B2342 probable
3-ketoacyl-CoA thiolase (acetyl-CoA acyltransferase)
(beta-ketothiolase) from Escherichia coli strain K-12 (436
aa), FASTA scores: opt: 914, E(): 0, (38.2% identity in
434 aa overlap); P55084|ECHB_HUMAN mitochondrial
trifunctonal enzyme (474 aa), FASTA scores: opt: 881, E():
0, (37.7 identity in 451 aa overlap). Contains PS00099
Thiolases active site. Belongs to the thiolase family."
/db_xref="EnsemblGenomes-Gn:Rv0243"
/db_xref="EnsemblGenomes-Tr:CCP42972"
/db_xref="GOA:O86361"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020610"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/TrEMBL:O86361"
/inference="protein motif:PROSITE:PS00099"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42972.1"
/translation="MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAA
LSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTG
LQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLV
GTLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDR
GFFDDLVSPFLGLYRDDNLRPNSSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASV
ALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQD
FDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPF
AATGGRILAQTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA"
gene 293604..293705
/gene="F6"
/gene_synonym="mcr14"
/gene_synonym="mpr13"
ncRNA 293604..293705
/gene="F6"
/gene_synonym="mcr14"
/gene_synonym="mpr13"
/product="Putative small regulatory RNA"
/note="F6, putative small regulatory RNA (See Arnvig and
Young, 2009; DiChiara et al., 2010). Alternate 3'-ends at
positions 293641 and 293661."
/ncRNA_class="other"
gene complement(293798..295633)
/gene="fadE5"
/locus_tag="Rv0244c"
CDS complement(293798..295633)
/codon_start=1
/transl_table=11
/gene="fadE5"
/locus_tag="Rv0244c"
/product="Probable acyl-CoA dehydrogenase FadE5"
/note="Rv0244c, (MTV034.10c), len: 611 aa. Probable
fadE5,acyl-CoA dehydrogenase, equivalent to
AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa),
FASTA scores: opt: 3598, E(): 0, (89.4% identity in 611 aa
overlap). Also highly similar to AL0211|MTV007.14 from
Mycobacterium tuberculosis (609 aa), FASTA scores: opt:
2576, E(): 0,(64.6% identity in 611 aa overlap); and to
various other bacterial proteins described as putative
acyl-CoA dehydrogenases e.g. AE0010|AE001025_6 from
Archaeoglobus fulgidus (387 aa), FASTA scores: opt: 229,
E(): 6.8e-08,(29.8% identity in 409 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0244c"
/db_xref="EnsemblGenomes-Tr:CCP42973"
/db_xref="GOA:O53666"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR020953"
/db_xref="InterPro:IPR025878"
/db_xref="InterPro:IPR034188"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:O53666"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42973.1"
/translation="MSHYRSNVRDQVFNLFEVLGVDKALGHGEFSDVDVDTARDMLAE
VSRLAEGPVAESFVEGDRNPPVFDPKTHSVMLPESFKKSVNAMLEAGWDKVGIDEALG
GMPMPKAVVWALHEHILGANPAVWMYAGGAGFAQILYHLGTEEQKKWAVLAAERGWGS
TMVLTEPDAGSDVGAARTKAVQQADGSWHIDGVKRFITSGDSGDLFENIFHLVLARPE
GAGPGTKGLSLYFVPKFLFDVETGEPGERNGVFVTNVEHKMGLKVSATCELAFGQHGV
PAKGWLVGEVHNGIAQMFEVIEQARMMVGTKAIATLSTGYLNALQYAKSRVQGADLTQ
MTDKTAPRVTITHHPDVRRSLMTQKAYAEGLRALYLYTATFQDAAVAEVVHGVDAKLA
VKVNDLMLPVVKGVGSEQAYAKLTESLQTLGGSGFLQDYPIEQYIRDAKIDSLYEGTT
AIQAQDFFFRKIVRDKGVALAHVSGQIQEFVDSGAGNGRLKTERALLAKALTDVQGMA
AALTGYLMAAQQDVTSLYKVGLGSVRFLMSVGDLIIGWLLQRQAAVAVAALDAGATGD
ERSFYEGKVAVASFFAKNFLPLLTSTREVIETLDNDIMELDEAAF"
gene 296005..296493
/locus_tag="Rv0245"
CDS 296005..296493
/codon_start=1
/transl_table=11
/locus_tag="Rv0245"
/product="Possible oxidoreductase"
/note="Rv0245, (MTV034.11), len: 162 aa. Possible
oxidoreductase, equivalent to AL022486|MLCB1883_17|T44882
probable oxidoreductase from Mycobacterium leprae (162
aa),FASTA scores: opt: 860, E(): 0, (83.4% identity in 157
aa overlap). Also similar to several hypothetical proteins
and various oxidoreductases e.g. AAK24246.1|AE005898
NADH:riboflavin 5'-phosphate oxidoreductase from
Caulobacter crescentus (174 aa);
Q02058|DIM6_STRCO|CAA45048.1 actinorhodin polyketide
dimerase from streptomyces coelicolor (177 aa), FASTA
scores: opt: 308, E(): 3. 2e-15, (37.8% identity in 143 aa
overlap). Also similar to Z84498|Rv1939|MTCY09F9.25c from
Mycobacterium tuberculosis (171 aa), FASTA scores: opt:
517, E(): 3.5e-30, (49.4% identity in 158 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0245"
/db_xref="EnsemblGenomes-Tr:CCP42974"
/db_xref="GOA:O53667"
/db_xref="InterPro:IPR002563"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/TrEMBL:O53667"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42974.1"
/translation="MNSTNNLTPSSLREAFGHFPTGVVAIAAEVDGVRQGLAASTFVP
VSLEPPLVSFCVQNTSTTWPKLTGVPMLGISVLGEAHDAAVRTLAAKTGDRFAGLETV
SNDAGAVFIKGTSVWLESAIEQLVPAGDHTIVVLRVNQVKVDPNVAPIVFHRSVLRRL
GV"
gene 296809..298119
/locus_tag="Rv0246"
CDS 296809..298119
/codon_start=1
/transl_table=11
/locus_tag="Rv0246"
/product="Probable conserved integral membrane protein"
/note="Rv0246, (MTV034.12), len: 436 aa (start uncertain).
Probable conserved integral membrane protein, similar to
Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from
Mycobacterium tuberculosis (512 aa), FASTA scores: opt:
712, E(): 0, (33.2% identity in 422 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0246"
/db_xref="EnsemblGenomes-Tr:CCP42975"
/db_xref="GOA:O53668"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O53668"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42975.1"
/translation="MAKTSHRVSSADGMSKRILRLIIAQSGFYSAALQLGNVSIVLPF
VVAELDAELWIAALIFPAFTAGGAIGNVVAPPAVAAVPRRHRLFIIVSCLAVLAGVNA
LCATIGKGSVAGILLVVNVTLIGVVSAISFVAFADLVAAMPSGTARARILLTEVGVGA
ALTAVVAATLSFVPDQHPLSRNIHLLWTAAVAMAISAAICRALPHRIVPRVHAAPGLH
KLVYVGWTAIRTNGWYRRYLLVQVLFGSVVLGSSFHSIRVAAVPGDQPDEVVAVVLFV
CVGLLGGIALWNRVRERFGLVGLFVGSALVSIAAAVLSIAFDLAGAWPNVVAIGLVIA
LVSIANQSVFTAGQLWIARDAEPGLRTSLISFGQLVINAGLVGMGLALGLIAQDHDAV
WPVMIVLLLNLTAAYSATRFAPAKSVDVRGLPQVSRTSRPKTGG"
gene complement(298116..298862)
/locus_tag="Rv0247c"
CDS complement(298116..298862)
/codon_start=1
/transl_table=11
/locus_tag="Rv0247c"
/product="Probable succinate dehydrogenase [iron-sulfur
subunit] (succinic dehydrogenase)"
/note="Rv0247c, (MTV034.13c), len: 248 aa. Probable
succinate dehydrogenase, iron-sulfur subunit, highly
similar to CAC44313.1|AL596043 putative succinate
dehydrogenase iron-sulfur subunit from Streptomyces
coelicolor (259 aa); and similar to iron-sulphur protein
subunits of fumarate reductase or succinate dehydrogenases
from many bacteria e.g. NP_147618.1|7521083|B72691
fumarate reductase iron-sulfur protein from Aeropyrum
pernix (305 aa); NP_069516.1|2649932|AAB90556.1|AE001057
succinate dehydrogenase iron-sulfur subunit B (sdhB) from
Archaeoglobus fulgidus (236 aa); etc. Also similar to
Q10761|FRDB_MYCTU|7431693|F70762 fumarate reductase
iron-sulfur protein from Mycobacterium tuberculosis (247
aa), FASTA scores: opt: 358, E():1e-16, (31.3% identity in
214 aa overlap). Contains PS00197 2Fe-2S
ferredoxins,iron-sulfur binding region signature. Note
that succinate dehydrogenase forms generally part of an
enzyme complex containing four subunits: a flavoprotein
(Rv0248c ?), an iron-sulfur (Rv0247c ?), and two
hydrophobic anchor proteins (Rv0249c ?)."
/db_xref="EnsemblGenomes-Gn:Rv0247c"
/db_xref="EnsemblGenomes-Tr:CCP42976"
/db_xref="GOA:O53669"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR004489"
/db_xref="InterPro:IPR006058"
/db_xref="InterPro:IPR009051"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR025192"
/db_xref="InterPro:IPR036010"
/db_xref="UniProtKB/TrEMBL:O53669"
/inference="protein motif:PROSITE:PS00197"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42976.1"
/translation="MTYSASMRVWRGDESCGELREFTVEVNEGEVVLDVILRLQQTQT
PDLAVRWNCKAGKCGSCSAEINGKPRLMCMTRMSTFDEDEIVTVTPMRTFPVIRDLVT
DVSFNYQKAREIPSFAPPKELQPSEYRMAQVDVARSQEFRKCIECFLCQNVCHVVRDH
EENKDAFAGPRFLMRIAELEMHPLDTRDRRSQAQEEHGLGYCNITKCCTEVCPENIKI
TDNALIPMKERVADRKYDPVVWLGSKLFRR"
gene complement(298863..300803)
/locus_tag="Rv0248c"
CDS complement(298863..300803)
/codon_start=1
/transl_table=11
/locus_tag="Rv0248c"
/product="Probable succinate dehydrogenase [iron-sulfur
subunit] (succinic dehydrogenase)"
/note="Rv0248c, (MTV034.14c), len: 646 aa. Probable
succinate dehydrogenase, flavoprotein subunit, highly
similar to flavoprotein subunit of various succinate
dehydrogenases e.g. M88696|RIRSDHA_1 flavoprotein from
Rickettsia prowazekii (596 aa), FASTA scores: opt:
651,E(): 0, (34.6 % identity in 598 aa overlap). Also
similar to truncated U00022_17 flavoprotein from
Mycobacterium leprae (401 aa), FASTA scores: opt: 677,
E(): 0, (39.0% identity in 423 aa overlap). Note that
succinate dehydrogenase forms generally part of an enzyme
complex containing four subunits: a flavoprotein (Rv0248c
?), an iron-sulfur (Rv0247c ?), and two hydrophobic anchor
proteins (Rv0249c ?)."
/db_xref="EnsemblGenomes-Gn:Rv0248c"
/db_xref="EnsemblGenomes-Tr:CCP42977"
/db_xref="GOA:O53670"
/db_xref="InterPro:IPR003953"
/db_xref="InterPro:IPR015939"
/db_xref="InterPro:IPR027477"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR037099"
/db_xref="UniProtKB/TrEMBL:O53670"
/inference="protein motif:PROSITE:PS00141"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42977.1"
/translation="MVEVERHSYDVVVIGAGGAGLRAVIEARERGLKVAVVCKSLFGK
AHTVMAEGGCAAAMGNANPKDNWKTHFGDTMRGGKFLNNWRMAELHAKEAPDRVWELE
TYGALFDRTDDGRISQRNFGGHTYPRLAHVGDRTGLELIRTLQQKVVSLQQEDHAELG
DYEARIKVFAECTITELLKDQGAIAGAFGYWRESGRFIVFEAPAVVLATGGIGKSFKV
TSNSWEYTGDGHALALRAGATLINMEFVQFHPTGMVWPPSVKGILVTEGVRGDGGVLK
NSENSRFMFDYIPPVFKGQYAETEEEADQWLKDNDSARRTPDLLPRDEVARAINSEVK
AGRGTPHGGVYLDIASRLTPAEIKRRLPSMYHQFKELAEVDITTQAMEVGPTCHYVMG
GVEVDADTGAATVPGLFAAGECAGGMHGSNRLGGNSLSDLLVFGRRAGLGAADYVRAL
SSRPAVSAEAIDAAAQQALSPFEGPKDGSAPENPYALHMDLQYVMNDLVGIIRNADEI
SRALTLLAELWSRYHNVLVEGHRQYNPGWNLSIDLRNMLLVSECVARAALQRTESRGG
HTRDDHPGMDPNWRRILLVCRATETMGTGGSGSGDSNCHINVTQQLQTPMRPDLLELF
EISELEKYYTDEELAEHPGRRG"
gene complement(300834..301655)
/locus_tag="Rv0249c"
CDS complement(300834..301655)
/codon_start=1
/transl_table=11
/locus_tag="Rv0249c"
/product="Probable succinate dehydrogenase [membrane
anchor subunit] (succinic dehydrogenase)"
/note="Rv0249c, (MTV034.15c), len: 273 aa. Probable
succinate dehydrogenase, membrane-anchor subunit for
succinate dehydrogenase encoded by Rv0247c and Rv0248c.
Highly similar to AC44315.1|AL596043 putative integral
membrane protein from Streptomyces coelicolor (278 aa).
Note that succinate dehydrogenase forms generally part of
an enzyme complex containing four subunits: a flavoprotein
(Rv0248c ?), an iron-sulfur (Rv0247c ?), and two
hydrophobic anchor proteins (Rv0249c ?)."
/db_xref="EnsemblGenomes-Gn:Rv0249c"
/db_xref="EnsemblGenomes-Tr:CCP42978"
/db_xref="GOA:O53671"
/db_xref="UniProtKB/TrEMBL:O53671"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42978.1"
/translation="MSAPTANRPAIGVFTPTRAQIPERTLRTDLWWLPPLLTNLGLLA
FICYATTRAFWGSQYWVEKYHYLTPFYSPCVSASCQPGASHLGVWFGHFPGWIPLGAM
VLPFLLGFRLTCYYYRKAYYRSVWQSPTSCAVPEPRAHYTGETRLPLIVQNTHRYFFY
IAVVVSLINTYDAIAAFHSPSGFGFGLGNVILTINVVLLWAYTISCHSCRHATGGRLK
HFSKHPVRYWIWTQVSKLNTRHMQFAWITLGTLALTDFYIMLVASGSITDLRFIG"
gene complement(301735..302028)
/locus_tag="Rv0250c"
CDS complement(301735..302028)
/codon_start=1
/transl_table=11
/locus_tag="Rv0250c"
/product="Conserved protein"
/note="Rv0250c, (MTV034.16c), len: 97 aa. Conserved
protein, equivalent to
MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486
hypothetical protein from Mycobacterium leprae (98
aa),FASTA scores: opt: 478, E(): 4.4e-28, (72.6% identity
in 95 aa overlap). Also similar to C-terminus of
AC44316.1|AL596043|SCBAC31E11.05c hypothetical protein
from Streptomyces coelicolor (146 aa). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0250c"
/db_xref="EnsemblGenomes-Tr:CCP42979"
/db_xref="UniProtKB/Swiss-Prot:O53672"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42979.1"
/translation="MSTTAELAELHDLVGGLRRCVTALKARFGDNPATRRIVIDADRI
LTDIELLDTDVSELDLERAAVPQPSEKIAIPDTEYDREFWRDVDDEGVGGHRY"
gene complement(302173..302652)
/gene="hsp"
/gene_synonym="acr2"
/gene_synonym="hrpA"
/gene_synonym="hsp20"
/locus_tag="Rv0251c"
CDS complement(302173..302652)
/codon_start=1
/transl_table=11
/gene="hsp"
/gene_synonym="acr2"
/gene_synonym="hrpA"
/gene_synonym="hsp20"
/locus_tag="Rv0251c"
/product="Heat shock protein Hsp (heat-stress-induced
ribosome-binding protein A)"
/note="Rv0251c, (MTV034.17c), len: 159 aa. Hsp (alternate
gene name: hsp20, hrpA, acr2), heat-stress-induced
ribosome-binding protein A (see citations below). Highly
similar to AAD39038.1|AF072875_1|AF072875 putative HSP20
from Mycobacterium smegmatis (145 aa), FASTA scores: opt:
479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and
similar to many bacterial and eukaryotic hsp proteins e.g.
P12811|HS2C_CHLRE chloroplast heat shock 22KD protein from
chlamydomonas reinhardtii (157 aa), FASTA scores: opt:
184,E(): 1.2e-05, (32.4% identity in 142 aa overlap). Also
similar to PCC6803 Spore protein sp21 from Synechocystis
sp. (146 aa), FASTA scores: opt: 213, E(): 1.2e-07, (30.3
identity in 145 aa overlap). Also similar to
P30223|14KD_MYCTU 14 KDA antigen (16 KDA antigen) 19K
major membrane protein (HSP 16.3) from Mycobacterium
tuberculosis (144 aa). Belongs to the small heat shock
protein (HSP20) family."
/db_xref="EnsemblGenomes-Gn:Rv0251c"
/db_xref="EnsemblGenomes-Tr:CCP42980"
/db_xref="GOA:O53673"
/db_xref="InterPro:IPR002068"
/db_xref="InterPro:IPR008978"
/db_xref="UniProtKB/TrEMBL:O53673"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42980.1"
/translation="MNNLALWSRPVWDVEPWDRWLRDFFGPAATTDWYRPVAGDFTPA
AEIVKDGDDAVVRLELPGIDVDKDVNVELDPGQPVSRLVIRGEHRDEHTQDAGDKDGR
TLREIRYGSFRRSFRLPAHVTSEAIAASYDAGVLTVRVAGAYKAPAETQAQRIAITK"
gene 302866..305427
/gene="nirB"
/gene_synonym="nasB"
/locus_tag="Rv0252"
CDS 302866..305427
/codon_start=1
/transl_table=11
/gene="nirB"
/gene_synonym="nasB"
/locus_tag="Rv0252"
/product="Probable nitrite reductase [NAD(P)H] large
subunit [FAD flavoprotein] NirB"
/note="Rv0252, (MTV034.18), len: 853 aa. Probable nirB
(alternate gene name: nasB), nitrite reductase [NAD(P)H]
large subunit, flavoprotein containing siroheme and a
2FE-2S iron-sulfur centre. Highly similar to many others
bacterial enzymes e.g. P08201|NIRB_ECOLI nitrite reductase
(NAD(P)H) large subunit from Escherichia coli strain K12
(847 aa), FASTA scores: opt: 2775, E(): 0, (49.8% identity
in 840 aa overlap); Q06458|NIRB_KLEPN nitrite reductase
(NAD(P)H) large subunit (957 aa), FASTA scores: opt:
2902,E(): 0, (54.2% identity in 827 aa overlap). Contains
PS00365 Nitrite and sulfite reductases
iron-sulfur/siroheme-binding site. Homodimer which
associates with NIRD|Rv0253. Cofactors: FAD; Iron;
Siroheme."
/db_xref="EnsemblGenomes-Gn:Rv0252"
/db_xref="EnsemblGenomes-Tr:CCP42981"
/db_xref="GOA:O53674"
/db_xref="InterPro:IPR005117"
/db_xref="InterPro:IPR006066"
/db_xref="InterPro:IPR006067"
/db_xref="InterPro:IPR007419"
/db_xref="InterPro:IPR012744"
/db_xref="InterPro:IPR017121"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036136"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR041575"
/db_xref="InterPro:IPR041854"
/db_xref="UniProtKB/TrEMBL:O53674"
/inference="protein motif:PROSITE:PS00365"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42981.1"
/translation="MPTAGSSRAPAAAREIVVVGHGMVGHRLVEAVRARDADGSLRIT
VLAEEGDAAYDRVGLTSYTESWDRALLALPGNDYAGDQRVRLLLNTRVTQIDRATKSV
VTAAGQRHRYDTLVLATGSYAFVPPVPGHDLPACHVYRTFDDLDAIRAGAQRTLDGGH
TDGGVVIGGGLLGLEAANALRQFGLQTHVVEMMPRLMAQQIDEAGGALLARMIADLGI
AVHVGTGTESIESVKHSDGSVWARVRLSDGEVIDAGVVIFAAGIRPRDELARAAGLAI
GDRGGVLTDLSCRTSDPDIYAVGEVAAIDGRCYGLVGPGYTSAEVVADRLLDGSAEFP
EADLSTKLKLLGVDVASFGDAMGATENCLEVVINDAVKRTYAKLVLSDDATTLLGGVL
VGDASSYGVLRPMVGAELPGDPLALIAPAGSGAGAGALGVGALPDSAQICSCNNVTKG
ELKCAIADGCGDVPALKSCTAAGTSCGSCVPLLKQLLEAEGVEQSKALCEHFSQSRAE
LFEIITATEVRTFSGLLDRFGRGKGCDICKPVVASILASTGSDHILDGEQASLQDSND
HFLANIQKNGSYSVVPRVPGGDIKPEHLILIGQIAQDFGLYTKITGGQRIDLFGARVD
QLPLIWQRLVDGGMESGHAYGKAVRTVKSCVGSDWCRYGQQDSVQLAIDLELRYRGLR
APHKIKLGVSGCARECAEARGKDVGVIATEKGWNLYVAGNGGMTPKHAQLLASDLDKE
TLIRYIDRFLIYYIRTADRLQRTAPWVESLGLDHVREVVCEDSLGLAEEFEAAMQRHV
ANYKCEWKGVLEDPDKLSRFVSFVNAPDAVDSTVTFTERAGRKVPVSIGIPRVRS"
gene 305453..305809
/gene="nirD"
/locus_tag="Rv0253"
CDS 305453..305809
/codon_start=1
/transl_table=11
/gene="nirD"
/locus_tag="Rv0253"
/product="Probable nitrite reductase [NAD(P)H] small
subunit NirD"
/note="Rv0253, (MTV034.19), len: 118 aa. Probable
nirD,nitrite reductase [NAD(P)H] small subunit, similar to
others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from
Escherichia coli strains K12 and O157:H7 (108 aa), FASTA
scores: opt: 271, E():1.7e-12, (41.9% identity in 105 aa
overlap). Associates with NIRB|Rv0252."
/db_xref="EnsemblGenomes-Gn:Rv0253"
/db_xref="EnsemblGenomes-Tr:CCP42982"
/db_xref="GOA:O53675"
/db_xref="InterPro:IPR012748"
/db_xref="InterPro:IPR017881"
/db_xref="InterPro:IPR036922"
/db_xref="PDB:4AIV"
/db_xref="UniProtKB/TrEMBL:O53675"
/protein_id="CCP42982.1"
/translation="MTLLNDIQVWTTACAYDHLIPGRGVGVLLDDGSQVALFRLDDGS
VHAVGNVDPFSGAAVMSRGIVGDRGGRAMVQSPILKQAFALDDGSCLDDPRVSVPVYP
ARVTPEGRIQVARVAV"
gene complement(305825..306349)
/gene="cobU"
/locus_tag="Rv0254c"
CDS complement(305825..306349)
/codon_start=1
/transl_table=11
/gene="cobU"
/locus_tag="Rv0254c"
/product="Probable bifunctional cobalamin biosynthesis
protein CobU: cobinamide kinase + cobinamide phosphate
guanylyltransferase"
/note="Rv0254c, (MTV034.20), len: 174 aa. Probable
cobU,cobalamin biosynthesis protein including a cobinamide
kinase and cobinamide phosphate guanylyltransferase.
Highly similar to many e.g. Q05599|COBU_SALTY cobinamide
kinase / cobinamide phosphate guanylyltransferase from
Salmonella typhimurium (181 aa), FASTA scores: opt: 308,
E(): 1.1e-14,(38.7% identity in 181 aa overlap);
P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional
cobalamin biosynthesis protein cobU from Escherichia coli
strains K12 and O157:H7 (181 aa); part of
AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa),
FASTA scores: opt: 445, E(): 3.6e-23, (46.0% identity in
176 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0254c"
/db_xref="EnsemblGenomes-Tr:CCP42983"
/db_xref="GOA:O53676"
/db_xref="InterPro:IPR003203"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O53676"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42983.1"
/translation="MRILVTGGVRSGKSTHAEALLGDAADVVYVAPGRPAAGSDPDWD
ARVALHRARRPPTWLTVETADVATALSEARSPVLVDCLGTWLTAIMDGEALWSAATAD
VYAVLEARLDGLCAALTGLPTAIVVTNEVGLGVVPSHSSGVLFRDLLGTINRRVAAVC
DEVHLVIAGRVLKL"
gene complement(306374..307858)
/gene="cobQ1"
/gene_synonym="cobQ"
/locus_tag="Rv0255c"
CDS complement(306374..307858)
/codon_start=1
/transl_table=11
/gene="cobQ1"
/gene_synonym="cobQ"
/locus_tag="Rv0255c"
/product="Probable cobyric acid synthase CobQ1"
/note="Rv0255c, (MTV034.21c), len: 494 aa. Probable
cobQ1,cobyric acid synthase, similar to many e.g.
Z46611|RCBLUGNS_8 cobyric acid synthase from R.capsulatus
(483 aa), FASTA scores: opt: 1239, E(): 0, (47.1% identity
in 493 aa overlap); P29932|COBQ_PSEDE cobyric acid
synthase from Pseudomonas denitrificans (484 aa), FASTA
scores: opt: 1168, E():0, (44.9% identity in 490 aa
overlap); etc. Belongs to the COBB/COBQ family, COBQ
subfamily. Note that previously known as cobQ."
/db_xref="EnsemblGenomes-Gn:Rv0255c"
/db_xref="EnsemblGenomes-Tr:CCP42984"
/db_xref="GOA:P9WP95"
/db_xref="InterPro:IPR002586"
/db_xref="InterPro:IPR004459"
/db_xref="InterPro:IPR011698"
/db_xref="InterPro:IPR017929"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029062"
/db_xref="InterPro:IPR033949"
/db_xref="UniProtKB/Swiss-Prot:P9WP95"
/protein_id="CCP42984.1"
/translation="MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNN
SMVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWGEV
ASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGDYVNMGLARHAG
LPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNKFRGDSDLLAPGLRDLERV
TGRRVYGTLPWHPDLWLDSEDALDLQGRRAAGTGARRVAVVRLPRISNFTDVDALGLE
PDLDVVFASDPRALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGIC
GGFQMLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGVPASG
YEIHHGRITRGDTAEEFLGGARDGPVFGTMWHGSLEGDALREAFLRETLGLAPSGSCF
LAARERRLDLLGDLVERHLDVDALLNLARHGCPPTLPFLAPGAP"
gene complement(307877..309547)
/gene="PPE2"
/locus_tag="Rv0256c"
CDS complement(307877..309547)
/codon_start=1
/transl_table=11
/gene="PPE2"
/locus_tag="Rv0256c"
/product="PPE family protein PPE2"
/note="Rv0256c, (MTV034.22c), len: 556 aa. PPE2, Member of
the M. tuberculosis PPE family, similar to many e.g.
Rv0280, Rv0286, etc. Equivalent to Z98756|MLCB2492.30 from
Mycobacterium leprae (572 aa), FASTA scores: opt:
1837,E(): 0, (62.9% identity in 461 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0256c"
/db_xref="EnsemblGenomes-Tr:CCP42985"
/db_xref="GOA:P9WI47"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI47"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42985.1"
/translation="MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIAYAET
ADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMATRQETAATAYGT
ALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNESDYARMWIQAATTMASYQAV
STAAVAAAPQTTPAPQIVKANAPTAASDEPNQVQEWLQWLQKIGYTDFYNNVIQPFIN
WLTNLPFLQAMFSGFDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFI
GADLAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPLLA
APLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIPTPTPTPAPAP
APTAVTAPTPPPGPPPPPVTAPPPVTGAGIQSFGYLVGDLNSAAQARKAVGTGVRKKT
PEPDSAEAPAAAAAPEEQVQPQRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQGAGT
LGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE"
gene 309699..310073
/locus_tag="Rv0257"
CDS 309699..310073
/codon_start=1
/transl_table=11
/locus_tag="Rv0257"
/product="Conserved hypothetical protein"
/note="Rv0257, len: 124 aa. Hypothetical
protein,orthologue of ML1828A conserved hypothetical
protein from Mycobacterium leprae. Replaced Rv0257c (older
annotation). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004).
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0257"
/db_xref="EnsemblGenomes-Tr:CCP42986"
/db_xref="UniProtKB/TrEMBL:L7N694"
/protein_id="CCP42986.1"
/translation="MTRVSWLPDRCLPRLPACGRGLRGSLPGDSGGTAPDSHRLPASS
SPDGKNIGMQSVDLHVERHLPSRGRSHRTVATVTCVTALGDIRSAQLSATGAWPAVLF
PSWSWLCGIGGGVDLQKPSCRA"
gene complement(310294..310749)
/locus_tag="Rv0258c"
CDS complement(310294..310749)
/codon_start=1
/transl_table=11
/locus_tag="Rv0258c"
/product="Conserved hypothetical protein"
/note="Rv0258c, (MTCY06A4.02c), len: 151 aa (alternative
start possible). Conserved hypothetical protein, showing
some similarity to Rv1685c|MTCI125_6 from Mycobacterium
tuberculosis (207 aa), FASTA scores: E(): 9.3e-07, (32.1%
identity in 140 aa overlap). Also some similarity with
AL049819|SCE7_13|T36295 probable transcription regulator
from Streptomyces coelicolor (204 aa), FASTA scores: opt:
158, E(): 0.00052, (27.0% identity in 111 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0258c"
/db_xref="EnsemblGenomes-Tr:CCP42987"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041678"
/db_xref="UniProtKB/TrEMBL:P95215"
/protein_id="CCP42987.1"
/translation="MARSQEPSRGLLDPVAKMLRLPFGTPDFIEKIVTGSVNQVGRRT
LYVLITTWDAAGGGPFAASAIATTGLAKTAEIVQSMFIGPVFNPLLKMLGADKIAIRA
SLCAAQLVGLGIMRYGVRSEPLHSMSVEMLVDAIGPTMQRYLVGDIGRG"
gene complement(310774..311517)
/locus_tag="Rv0259c"
CDS complement(310774..311517)
/codon_start=1
/transl_table=11
/locus_tag="Rv0259c"
/product="Conserved hypothetical protein"
/note="Rv0259c, (MTCY06A4.03c), len: 247 aa. Conserved
hypothetical protein, showing some similarity to
Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis
(281 aa), FASTA scores: E(): 9.5e-16, (33.6 % identity in
235 aa overlap). Also some similarity with
CAC33938.1|AL589708 putative secreted protein from
Streptomyces coelicolor (248 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0259c"
/db_xref="EnsemblGenomes-Tr:CCP42988"
/db_xref="GOA:P95216"
/db_xref="InterPro:IPR002762"
/db_xref="UniProtKB/TrEMBL:P95216"
/protein_id="CCP42988.1"
/translation="MNLILTAHGTRRPSGVAMIADIAAQVSALVDRTVQVAFVDVLGP
SPSEVLSALSCRPAIVVPAFLSRGYHVRTDLPAHVAASAHPHVTVTPALGPCREIAQI
VTQQLVESGWRPGDSVILAAAGASDRRARADLHTTRTLVSELTGSWVDMGFAGTGGPD
VRTAVQRARDRAEANRGARRVAVASFLLAEGLFQERLRASGADVVTRPLGTHPGLAQL
VANRFRSAVARQQRLHRWHGTPTPVTLDL"
gene complement(311514..312659)
/locus_tag="Rv0260c"
CDS complement(311514..312659)
/codon_start=1
/transl_table=11
/locus_tag="Rv0260c"
/product="Possible transcriptional regulatory protein"
/note="Rv0260c, (MTCY0A4.04c), len: 381 aa. Possible
two-component response regulator, highly similar to
CAB72204.1|AL138851 putative transcriptional regulator
from Streptomyces coelicolor (395 aa); and similar to
O34394|D69851|YJJA conserved hypothetical protein from
Bacillus subtilis (270 aa), FASTA scores: opt: 312, E():
7.4e-14, (25.8% identity in 267 aa overlap). Also some
similarity to regulatory proteins at C-terminal region
e.g. CUTR_STRLI|Q03756 transcriptional regulatory protein
(217 aa), FASTA scores: opt: 138, E(): 0.02, (30.6%
identity in 111 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0260c"
/db_xref="EnsemblGenomes-Tr:CCP42989"
/db_xref="GOA:P95217"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR003754"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036108"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039793"
/db_xref="UniProtKB/TrEMBL:P95217"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42989.1"
/translation="MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKM
IALPDDDELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARII
SRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFP
EFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLE
RSRELDIEDQLLAALRTDVHAMCVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEEL
PLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRV
LPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKRGYRLAVDSRHDDV"
gene complement(312759..314168)
/gene="narK3"
/locus_tag="Rv0261c"
CDS complement(312759..314168)
/codon_start=1
/transl_table=11
/gene="narK3"
/locus_tag="Rv0261c"
/product="Probable integral membrane nitrite extrusion
protein NarK3 (nitrite facilitator)"
/note="Rv0261c, (MTCY06A4.05c), len: 469 aa. Probable
nirK3, nitrite extrusion protein, integral membrane
protein possibly member of major facilitator superfamily
(MFS),equivalent to AAB41700.1|U72744 nitrite extrusion
protein from Mycobacterium fortuitum (471 aa); and
2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein
homolog from Mycobacterium leprae (517 aa; longer in
N-terminus). Also similar to other nitrite extrusion
proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion
protein 1 from Escherichia coli strain K12 (463 aa), FASTA
scores: opt: 755, E(): 0, (35.0% identity in 466 aa
overlap). Belongs to the nark/NASA family of
transporters."
/db_xref="EnsemblGenomes-Gn:Rv0261c"
/db_xref="EnsemblGenomes-Tr:CCP42990"
/db_xref="GOA:P95218"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:P95218"
/protein_id="CCP42990.1"
/translation="MGRSHQISDWDPEDSVAWEAGNKFIARRNLIWSVAAEHVGFSVW
SLWSVMVLFMPTSVYGFSAGDKFLLGATATLVGACLRFPYTFATAKFGGRNWTIFSAL
VLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAASMTNINAFFPQRLKGAALA
LNAGGGNLGVPMVQLVGLLVIATAGDREPYWVCAIYLVLLAVAGLGAALYMDNLTEYR
IELNTMRAVVSEPHTWVISLLYIGTFGSFIGFSFAFGQVLQINFIASGQSTAQASLHA
AQIAFLGPLLGSLSRIYGGKLADRIGGGRVTLAAFCAMLLATGILISASTFGDHLAGP
MPTATMVGYVIGFTALFILSGIGNGSVYKMIPSIFEARSHSLQISEAERRQWSRSMSG
ALIGLAGAVGALGGVGVNLALRESYLTSGTATSAFWAFGVFYLVASVLTWAIYVRRGL
KSAGELVPATTAPAGLAYV"
gene complement(314309..314854)
/gene="aac"
/locus_tag="Rv0262c"
CDS complement(314309..314854)
/codon_start=1
/transl_table=11
/gene="aac"
/locus_tag="Rv0262c"
/product="Aminoglycoside 2'-N-acetyltransferase Aac
(Aac(2')-IC)"
/note="Rv0262c, (MTCY06A4.06c), len: 181 aa.
Aac,aminoglycoside 2'-N-acetyltransferase (aac(2')-IC)
(see citation below), highly similar to
NP_302635.1|NC_002677 aminoglycoside
2'-N-acetyltransferase from Mycobacterium leprae (182 aa);
Q49157|AAC2_MYCFO|AAC aminoglycoside
2'-N-acetyltransferase from Mycobacterium fortuitum (195
aa), Contains GNAT (Gcn5-related N-acetyltransferase)
domain. See Vetting et al. 2005. FASTA scores: opt:
884,E(): 0, (69.1% identity in 181 aa overlap); and
P94968|AAC2_MYCSM|AAC aminoglycoside
2'-N-acetyltransferase from Mycobacterium smegmatis (210
aa) (see also citation below). Also similar to
Q52424|AAC2_PROST aminoglycoside 2'-N-acetyltransferase
from Providencia stuartii (178 aa). Belongs to the
AAC(2')-I family of acetyltransferases. Note that
previously known as aac(2')-IC."
/db_xref="EnsemblGenomes-Gn:Rv0262c"
/db_xref="EnsemblGenomes-Tr:CCP42991"
/db_xref="GOA:P9WQG9"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="PDB:1M44"
/db_xref="PDB:1M4D"
/db_xref="PDB:1M4G"
/db_xref="PDB:1M4I"
/db_xref="UniProtKB/Swiss-Prot:P9WQG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42991.1"
/translation="MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHT
LGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDA
VEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLP
IDISLDTSAELMCDWRAGDVW"
gene complement(314864..315766)
/locus_tag="Rv0263c"
CDS complement(314864..315766)
/codon_start=1
/transl_table=11
/locus_tag="Rv0263c"
/product="Conserved hypothetical protein"
/note="Rv0263c, (MTCY06A4.07c), len: 300 aa. Conserved
hypothetical protein, equivalent to NP_302634.1|NC_002677
conserved hypothetical protein from Mycobacterium leprae
(305 aa). Also similar to others e.g. AL121596|SC51A_21
hypothetical protein from Streptomyces coelicolor (285
aa),FASTA scores: opt: 714, E(): 0, (45.3% identity in 289
aa overlap); NP_233164.1|NC_002506 conserved hypothetical
protein from Vibrio cholerae (309 aa);
NP_406216.1|NC_003143 conserved hypothetical protein from
Yersinia pestis (316 aa); YH30_HAEIN|P44298|hi1730
hypothetical protein from Haemophilus influenzae (309
aa),FASTA scores: opt: 430, E(): 3e-20, (29.6% identity in
284 aa overlap); etc. Also similar to carboxylases eg
NP_415240.1|NC_000913|P75745|YBGK_ECOLI putative
carboxylase from Escherichia coli strain K12 (310
aa),FASTA score: (34.6% identity in 286 aa overlap);
NP_459698.1|NC_003197 putative carboxylase from Salmonella
typhimurium (310 aa); and to middle part of
NP_420636.1|NC_002696 urea amidolyase-related protein from
Caulobacter crescentus (1207 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0263c"
/db_xref="EnsemblGenomes-Tr:CCP42992"
/db_xref="InterPro:IPR003778"
/db_xref="InterPro:IPR029000"
/db_xref="UniProtKB/TrEMBL:P95220"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42992.1"
/translation="MTTLEILRSGPLALVEDLGRAGLAHLGVGRSGAADRRSHTLANR
LVANPDDWATVEVTFGGFSARVRGGDVDIAVTGADTDPTVNGIMVGTNSIHHVRDGQV
ISLGTPRAGLRTYLAVRGGVCVEPVLGSRSYDVMSAIGPSPLRAGDVLPVGEHTDDYP
ELDQAPVAAIEEHLVELRVVPGPRDDWLVDPDALVHTIWMASNRSDRVGMRLQGRPLQ
HRWPDRQLPGEGVTRGAIQVPPNGLPVILGPDHPITGSYPVVGVITDEDIDKVAQIRP
GQYVRLHWARPRSRLPGQGVTQAW"
gene complement(315783..316415)
/locus_tag="Rv0264c"
CDS complement(315783..316415)
/codon_start=1
/transl_table=11
/locus_tag="Rv0264c"
/product="Conserved hypothetical protein"
/note="Rv0264c, (MTCY06A4.08c), len: 210 aa. Conserved
hypothetical protein, equivalent to CAC32080.1|AL583926
conserved hypothetical protein from Mycobacterium leprae
(222 aa). Also similar to others hypothetical proteins
e.g. AL121596|SC51A_20 from Streptomyces coelicolor (252
aa),FASTA scores: opt: 420, E(): 2.7e-20, (41.7% identity
in 204 aa overlap); P75744|YBGJ_ECOLI hypothetical 23.9 KD
protein from Escherichia coli (218 aa), FASTA scores: E():
2.1e-14, (35.7% identity in 182 aa overlap);
YH31_HAEIN|P44299|hi173 hypothetical protein from
Haemophilus influenzae (213 aa), FASTA scores: opt:
252,E(): 8.3e-10, (31.1% identity in 183 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0264c"
/db_xref="EnsemblGenomes-Tr:CCP42993"
/db_xref="GOA:P95221"
/db_xref="InterPro:IPR003833"
/db_xref="InterPro:IPR010016"
/db_xref="InterPro:IPR029000"
/db_xref="UniProtKB/TrEMBL:P95221"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42993.1"
/translation="MDAALACTVLDYGDHALMLQCDSTADAMAWTDALRAAALPGVVD
IVAASRTVLVKLDAPRYQGVTRQRLRRLRVTPEAVAAADHRCDLVIDVVYDGPDLAEV
ARCTGLTTAAVINAHTATGWRAGFSGSAPGFAYLIDGDPSLRVPRRPERRTSMPPGSV
ALADGFSAIYPSQAPSDWQIIGHTDAVLWDVDRPQPALLTPGMWVQFRAA"
gene complement(316511..317503)
/gene_synonym="fecB2"
/locus_tag="Rv0265c"
CDS complement(316511..317503)
/codon_start=1
/transl_table=11
/gene_synonym="fecB2"
/locus_tag="Rv0265c"
/product="Probable periplasmic iron-transport lipoprotein"
/note="Rv0265c, (MTCY06A4.09c), len: 330 aa. Probable
iron-transport lipoprotein, most similar to
T36412|5763945|CAB53324.1|AL109974 probable
iron-siderophore binding lipoprotein from Streptomyces
coelicolor (350 aa); and (N-terminus may be incorrect) to
T14166|3560508|AAC82551.1|AF027770 fxuD protein from
Mycobacterium smegmatis (420 aa), FASTA scores: opt:
385,E(): 1.5e-16, (32.3% identity in 232 aa overlap). Also
similar to AAB97475.1|U02617 DtxR/iron regulated
lipoprotein precursor from Corynebacterium diphtheriae
(355 aa); FECB_ECOLI|P15028 iron(III) dicitrate-binding
periplasmic protein (300 aa), FASTA scores: opt: 191, E():
2.3e-05, (26.5% identity in 196 aa overlap). Contains
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site. Note that previously known as fecB2."
/db_xref="EnsemblGenomes-Gn:Rv0265c"
/db_xref="EnsemblGenomes-Tr:CCP42994"
/db_xref="GOA:L7N6B2"
/db_xref="InterPro:IPR002491"
/db_xref="InterPro:IPR006311"
/db_xref="PDB:4PM4"
/db_xref="UniProtKB/TrEMBL:L7N6B2"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42994.1"
/translation="MRQGCSRRGFLQVAEAAAATGLFAGCSSPKPPPGTPGGAAVTIT
HLFGQTVIKEPPKRVVSAGYTEQDDLLAVDVVPIAVTDWFGDQPFAVWPWAAPKLGGA
RPAVLNLDNGIQIDRIAALKPDLIVAINAGVDADTYQQLSAIAPTVAQSGGDAFFEPW
KDQARSIGQAVFAADRMRSLIEAVDQKFAAVAQRHPRWRGKKALLLQGRLWQGNVVAT
LAGWRTDFLNDMGLVIADSIKPFAVDQRGVIPRDHIKAVLDAADVLIWMTESPEDEKA
LLADPEIAASQATAQRRHIFTSKEQAGAIAFSSVLSYPVVAEQLPPQISQILGA"
gene complement(317525..321154)
/gene="oplA"
/locus_tag="Rv0266c"
CDS complement(317525..321154)
/codon_start=1
/transl_table=11
/gene="oplA"
/locus_tag="Rv0266c"
/product="Probable 5-oxoprolinase OplA (5-oxo-L-prolinase)
(pyroglutamase) (5-OPASE)"
/note="Rv0266c, (MTCY06A4.10c), len: 1209 aa. Probable
oplA, 5-oxoprolinase, highly similar to others or to
hypothetical proteins e.g. AAK24340.1|AE005906
hydantoinase/oxoprolinase from Caulobacter crescentus
(1196 aa); NP_103129.1|14022305|BAB48915.1|AP002997
5-oxoprolinase from Mesorhizobium loti (1210 aa);
CAC48426.1|AL603642 conserved hypothetical protein from
Sinorhizobium meliloti (1205 aa);
S77037|slr0697|1006579|BAA10729.1|D6400 hypothetical
protein from Synechocystis sp. strain PCC 6803 (1252
aa),FASTA scores: opt: 2016, E(): 0, (51.4% identity in
1247 aa overlap); P97608|OPLA_RAT|T42756|11278797
5-oxoprolinase (5-oxo-L-prolinase) (pyroglutamase)
(5-OPASE) from Rattus norvegicus (1288 aa); etc. Belongs
to the oxoprolinase family."
/db_xref="EnsemblGenomes-Gn:Rv0266c"
/db_xref="EnsemblGenomes-Tr:CCP42995"
/db_xref="GOA:P95223"
/db_xref="InterPro:IPR002821"
/db_xref="InterPro:IPR003692"
/db_xref="InterPro:IPR008040"
/db_xref="UniProtKB/TrEMBL:P95223"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42995.1"
/translation="MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDA
AVAGIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALRIAYQN
RPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGEKMRQAHADGIRAVAV
VCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRR
YINQVADQMRGVRLMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHV
IGFDMGGTSTDVSHYAGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYR
VGPDSAGADPGPACYRGGGPLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRG
FTDLAADIAARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHDVTRYALTTFGG
AGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTAMREQSVEIPLGPAAPQRLA
SVAESLERAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIPVQLAEIETMATAFESS
HRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETVRIYSNGLWRD
APLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAA
TRAGFEAGFEADPVLLEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALFDPDG
NLVANAPHIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGGTHLPDITVITPV
FNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAE
TRRLLTEAPFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDN
AEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQLDTNFNAP
TSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQA
ITGALFAALGVQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMTNS
RLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMTVSTLSGHRRV
RPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTS
ARRRR"
gene 321331..322722
/gene="narU"
/locus_tag="Rv0267"
CDS 321331..322722
/codon_start=1
/transl_table=11
/gene="narU"
/locus_tag="Rv0267"
/product="Probable integral membrane nitrite extrusion
protein NarU (nitrite facilitator)"
/note="Rv0267, (MTCY06A4.11), len: 463 aa. Probable
narU,nitrite extrusion protein, integral membrane protein
possibly member of major facilitator superfamily
(MFS),similar to other nitrite extrusion proteins e.g.
NARU_ECOLI|P37758 nitrite extrusion protein 2 from
Escherichia coli (462 aa), FASTA scores: opt: 630, E():
4.4e-33, (38.9% identity in 463 aa overlap); and
NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from
Escherichia coli strain K12 (463 aa), FASTA scores: opt:
607, E(): 1.3e-31, (42.0% identity in 457 aa overlap).
Also similar to Rv0261c, Rv2329c, Rv1737c, and to
MLCB22_25 from Mycobacterium leprae (517 aa), FASTA score:
(35.1 identity in 459 aa overlap). Belongs to the
nark/NASA family of transporters."
/db_xref="EnsemblGenomes-Gn:Rv0267"
/db_xref="EnsemblGenomes-Tr:CCP42996"
/db_xref="GOA:P95224"
/db_xref="InterPro:IPR004737"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:P95224"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42996.1"
/translation="MALTTAPAIDYALPRQQDEGDHWIDDWRPEDPVFWETIGRPIAR
RNLIFSIFAEHVGFSVWMLWSIVVVQMTAAAPGHPAASGWALSASQALCLVAVPSGVG
AFLRLPYTFAIPIFGGRNWTTVSAALLVIPCLLLAWAVSHPSLPFAVLVVIAATAGFG
GGNFASSMANISFFYPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGSGVALSRAG
LFFVPLAVAAAVCAFLFMNNLTEAKADVKPVWQSLRHADTWIMSLLYIGTFGSFIGYS
AAFPTLLKTVFGRGDIALGWAFLGAGIGSLVRPLGGKLADRIGGARITAASFVMLAAG
AAAALWSVQSVNLPVFFVSFMFLFVATGIGNGSSYRMISRIFQVKGEVAGGDPETMVN
MRRQAAGALGIISSIGAFGGFVVPLAYAWSKVHFGNIEPALHFYVAFFLALLVVTWYC
YLRRTTPMGQVGV"
gene complement(322764..323273)
/locus_tag="Rv0268c"
CDS complement(322764..323273)
/codon_start=1
/transl_table=11
/locus_tag="Rv0268c"
/product="Hypothetical protein"
/note="Rv0268c, (MTCY06A4.12c), len: 169 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0268c"
/db_xref="EnsemblGenomes-Tr:CCP42997"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:P95225"
/protein_id="CCP42997.1"
/translation="MGTRSKSRTRQLKQSNGCTATTSGASDRRRRARRRTAPAWLRED
EWLRHHLPHPPRQLSRCLHRRRRSACHHRYSRRTPKGGLPMTSSLVPISEARAHLSRL
VRESADDDVVLMNHGRPAAILISAERYESLMEELEDLRDRLSVHEREHVTMPLDKLGA
ELGVDIGRV"
gene complement(323338..324531)
/locus_tag="Rv0269c"
CDS complement(323338..324531)
/codon_start=1
/transl_table=11
/locus_tag="Rv0269c"
/product="Conserved hypothetical protein"
/note="Rv0269c, (MTCY06A4.13c), len: 397 aa. Conserved
hypothetical protein, highly similar to AL079355|SC4C6_19
hypothetical protein from Streptomyces coelicolor (341
aa),FASTA scores: opt: 1019, E(): 0, (46.5% identity in
344 aa overlap), and similar to other proteins e.g.
CAC49016.1|AL603644 putative ATP-dependent DNA ligase
protein from Sinorhizobium meliloti (636 aa); O34398 YKOU
protein from Bacillus subtilis (611 aa), FASTA score:
(27.2% identity in 283 aa overlap). Also similar to
proteins from Mycobacterium tuberculosis e.g.
Rv3062,Rv3731 (both DNA ligases), and Rv0938, Rv3730c."
/db_xref="EnsemblGenomes-Gn:Rv0269c"
/db_xref="EnsemblGenomes-Tr:CCP42998"
/db_xref="UniProtKB/TrEMBL:P95226"
/protein_id="CCP42998.1"
/translation="MSRMAAPVSLDVHGRQVIVTHPGRVVFPAHNDRKGYTKFDLVRY
YLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPANRPDWVDVAELHYASGRSAA
EAVIHDAAGLAWVINLGCVDLNPHPVLAGDLDHPDELRVDLDPMPGVAWQRVVEVALV
VREVLEDYGLTAWPKTSGSRGFHVYARIAPCWSFPQVRLAAQTVAREVERRLPDAATS
RWWKEEREGVFVDFNQNAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMAT
VPSRLADIGDPWAGMDDAVGRLDRLLMLAEELGPPQKAQSAKPLIEIARAKTRAEAMA
ALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRIRINLQHVPADQRPPQEELIADY
SPWPR"
gene 324567..326249
/gene="fadD2"
/locus_tag="Rv0270"
CDS 324567..326249
/codon_start=1
/transl_table=11
/gene="fadD2"
/locus_tag="Rv0270"
/product="Probable fatty-acid-CoA ligase FadD2
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0270, (MTCY06A4.14), len: 560 aa. Probable
fadD2,fatty-acid-CoA synthetase, similar to many e.g.
LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from
Escherichia coli (561 aa), FASTA scores: opt: 544, E():
2.9e-26, (27.7% identity in 535 aa overlap). Also similar
to others from Mycobacterium tuberculosis e.g.
MTCY493_2,MTCY8D5_9, MTCY6G11_8, etc. Contains PS00455
Putative AMP-binding domain signature."
/db_xref="EnsemblGenomes-Gn:Rv0270"
/db_xref="EnsemblGenomes-Tr:CCP42999"
/db_xref="GOA:P95227"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:P95227"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP42999.1"
/translation="MPNLTDLPGQAVSKLQKSIGQYVARGTAELHYLRKIIESGAIGL
EPPLNYAALAADIRKWGEVGMLPSHNARRAPNRAAVIDEEGTLTFSELDEAAHAVANG
LLAKGVRAGDGVAILARNHRWFVIANYGAARVGARIILLNSEFSGPQIKEVSDREGAK
VIIYDDEYTKAVSLAQPPLGKLRALGVNPDDDKPSGSSDETLAELIAHSSTAPAPKAS
RRASIIILTSGTTGTPKGANRNTPPTLAPIGGILSHVPFKAGEVTLLPSPMFHALGYM
HAALAMFLGSTLVLRRRFKPALVLEDIEKHKATSMVVVPVMLSRILDQLEKTEPKPDL
SSLKIVFVSGSQLGAELATRALGDLGPVIYNMYGSTEVAFATIAGPKDLQFNPSTVGP
VVKGVTVKILDENGNEVPQGAVGRIFVGNAFPFEGYTGGGGKQIIDGLLSSGDVGYFD
ERGLLYVSGRDDEMIVSGGENVFPAEVEDLISGHPDVVEAAAIGVDDKEFGARLRAFV
VKKPGADLDEDTIKQYVRDHLARYKVPREVIFLDELPRNPTGKVLKRELRKL"
gene complement(326266..328461)
/gene="fadE6"
/locus_tag="Rv0271c"
CDS complement(326266..328461)
/codon_start=1
/transl_table=11
/gene="fadE6"
/locus_tag="Rv0271c"
/product="Probable acyl-CoA dehydrogenase FadE6"
/note="Rv0271c, (MTCY06A4.15c), len: 731 aa. Probable
fadE6, acyl-CoA dehydrogenase, with C-terminal half
similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA
dehydrogenase (short-chain) from Homo sapiens (412 aa),
FASTA scores: opt: 339, E(): 1.3e-13, (28.1% identity in
288 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0271c"
/db_xref="EnsemblGenomes-Tr:CCP43000"
/db_xref="GOA:P95228"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P95228"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43000.1"
/translation="MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENPPPYW
QAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSAIASALIAAHDP
QAKVLAELATGAAIAAYALDSGLTATRHGDVLVIRGEVRAVPAAAQASVLVLPVAIES
RDEWVVLRNDQLEIEAVKSLDPLRPIAHVRANAVDVSDDALLSNLTMTTAHALMSTLL
SAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMIADTERATAAVWDAAR
ALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCIQVHGGIGFTWEHDTNVYYRRALM
LAACFGRGSEYPQRVVDTATTAGMRPVDIDLDPSTEKLRAQIRAEVAALKAMPREPRT
VAIAEGGWVLPYLPKPWGRAASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGT
DNQKQRLLPPTFRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQ
YSQWGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLDDVFVP
DELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVRDYRFEGQFDQVAR
HRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAISKLLSMRTGQGYAEFAVSSFGT
DAVIGDTERLPGKWGEYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP"
gene complement(328575..329708)
/locus_tag="Rv0272c"
CDS complement(328575..329708)
/codon_start=1
/transl_table=11
/locus_tag="Rv0272c"
/product="Unknown protein"
/note="Rv0272c, (MTCY06A4.16c), len: 377 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv0272c"
/db_xref="EnsemblGenomes-Tr:CCP43001"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P95229"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43001.1"
/translation="MTGRAATPGVIREFVGLPSRTAGRAAAGGHPCQGLYHHSVGRKP
KVALIAAHYQIDFSEHYLAEYMAIRGIGFLGWNTRFRGFESSFLLDHALVDIGVGVRW
LREVQGVETVVLLGNSGGGSLMAAYQSQAVDPNVTPLDGMRPAAGVTELPAADAYVAA
AAHPGRPDVLTAWMDAAVIDENDPVATDPELDLFDERNGPPYSPEFISRYRSAQVKRN
HTITDWAESELKRVRAAGFSDRPFSVMRTWADPRMVDPSIEPTKRRPNQCYAGTPVKA
NRSAHGIAAACTLRGWLGMWSLRVAQTRAAPHLARITCPALVLNAEADTGIFPSDAQQ
IYDGLASSDKTQVSIDTDHYFTTPGARSEQADTIAKWIAKRWR"
gene complement(329705..330325)
/locus_tag="Rv0273c"
CDS complement(329705..330325)
/codon_start=1
/transl_table=11
/locus_tag="Rv0273c"
/product="Possible transcriptional regulatory protein"
/note="Rv0273c, (MTV035.01c), len: 206 aa (start
uncertain). Possible transcriptional regulator, showing
some similarity to hypothetical regulators from
Mycobacterium tuberculosis e.g. P96222|Rv3855|MTCY01A6.13c
(216 aa); O08377|Rv1534|MTCY07A7A.03 (225 aa), FASTA
scores: opt: 123, E(): 3.2e-06, (28.5% identity in 172 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0273c"
/db_xref="EnsemblGenomes-Tr:CCP43002"
/db_xref="GOA:O86342"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O86342"
/protein_id="CCP43002.1"
/translation="MPDFPTQRGRRTQAAIDAAARTVVVRNGILATTVADITAEAGRS
AASFYNYYDSKEAMVRQWALRFRDDANQRALSVIRHGLSDRERAYEAAAAHWYTYRNR
LAEAISVSQLAMVSDDFAQYWSEICQIPISFITETVKRAQAHGYCVGDDPQLMAEAIV
AMFNQFCYLQLSGKRSRRGQPDDQACIQTLANIYYRAIYSKEDSSN"
gene 330422..331003
/locus_tag="Rv0274"
CDS 330422..331003
/codon_start=1
/transl_table=11
/locus_tag="Rv0274"
/product="Conserved protein"
/note="Rv0274, (MTV035.02), len: 193 aa. Conserved
protein,highly similar to AAK25058.1|AE005973 conserved
hypothetical protein from Caulobacter crescentus (174 aa).
Shows also some similarity to others hypothetical proteins
e.g. AJ002571|BSAJ2571_7 from Bacillus subtilis (316
aa),FASTA scores: opt: 138, E(): 0.033, (27.1% identity in
133 aa overlap). Previous hits with Q56415|M85195
fosfomycin-resistance protein from serratia marcescens
(141 aa), FASTA scores: opt: 82, E(): 1.1e -08, (29.1%
identity in 151 aa overlap). Contains PS00082 Extradiol
ring-cleavage dioxygenases signature near C-terminus. May
belong to the vicinal-oxygen-chelate (VOC) superfamily of
metalloenzymes (See Rawat et al., 2003)."
/db_xref="EnsemblGenomes-Gn:Rv0274"
/db_xref="EnsemblGenomes-Tr:CCP43003"
/db_xref="GOA:O53680"
/db_xref="InterPro:IPR000486"
/db_xref="InterPro:IPR004360"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="UniProtKB/TrEMBL:O53680"
/inference="protein motif:PROSITE:PS00082"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43003.1"
/translation="MIKPHNTNTEFELGGINHVALVCSDMARTVDFYSNILGMPLIKA
LDLPGGQGQHFFFDAGNGDCVAFFWFADAPDRVPGLSSPVAIPGIGDITSAVSTMNHL
AFHVPAERFDAYRQRLKDKGVRVGPVLNHDDSETQVSAVVHPGVYVRSFYFQDPDGIT
LEFACWTKEFTTSDAQAVPKTAADRRPPVAADR"
gene complement(330933..331658)
/locus_tag="Rv0275c"
CDS complement(330933..331658)
/codon_start=1
/transl_table=11
/locus_tag="Rv0275c"
/product="Possible transcriptional regulatory protein
(possibly TetR-family)"
/note="Rv0275c, (MTV035.03c), len: 241 aa. Possible
transcriptional regulator, TetR family, similar to others
e.g. Q9RJE7|SCF81.04c putative TetR-family transcriptional
regulator from Streptomyces coelicolor (219 aa);
Q9FBI8|SCP8.33c putative TetR-family transcriptional
regulator from Streptomyces coelicolor (213 aa);
Q9I2Q9|PA1836 probable transcriptional regulator from
Pseudomonas aeruginosa (193 aa); etc. Also shows some
similarity with Rv0825c from Mycobacterium tuberculosis
(213 aa), FASTA scores: opt: 230, E(): 2.7e-07, (32.6%
identity in 190 aa overlap). Seems to belong to the
TetR/AcrR family of transcriptional regulators (M.
tuberculosis regulatory protein family with many TetR
orthologues)."
/db_xref="EnsemblGenomes-Gn:Rv0275c"
/db_xref="EnsemblGenomes-Tr:CCP43004"
/db_xref="GOA:L7N6A2"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:L7N6A2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43004.1"
/translation="MTRSDRPYRGVEAAERLATRRRQSLSAGLDLLGSDQHDIAELTI
RTICRRAGLSVRYFYESFTDKDEFVGRVFDWVVAELVATTQAAVTAVPAREQTRAGMA
NIVRTITADARVGRLLFSTQLANAVITRKRAESSALFAMLSGQHAVDTLHAPANDHVK
AVAHFAVGGVGQTISAWLAGDVRLDPDQLVDQLAALLDELTDPNLSRPRVAATAAKSG
ANDPQPPEVAGQPPSSARPARRS"
gene 331748..332668
/locus_tag="Rv0276"
CDS 331748..332668
/codon_start=1
/transl_table=11
/locus_tag="Rv0276"
/product="Conserved hypothetical protein"
/note="Rv0276, (MTV035.04), len: 306 aa. Conserved
hypothetical protein, similar to Rv2237|Z70692|MTCY427.18
from Mycobacterium tuberculosis (296 aa), FASTA scores:
opt: 874, E(): 0, (49.6% identity in 282 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0276"
/db_xref="EnsemblGenomes-Tr:CCP43005"
/db_xref="GOA:O53682"
/db_xref="InterPro:IPR018713"
/db_xref="UniProtKB/TrEMBL:O53682"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43005.1"
/translation="MAISLVAHQPIPHVERPMADPPRLQLARRRRSAAGPGGNEDSLM
GVALLAGPANVIMELAMPGVGYGVLESRVESGRLDRHPIKRARTTFTYVAVAVAGSDD
QKAAFRRAVNKVHAQVYSTPESPVSYHAFDPELQLWVAACLYKGGVDVYRTFVGEMDD
EEADHHYRAGMAMGTTLQVPPQMWPPDRAAFDRYWRQSLDRVHIDDVVRDYLYPIVAL
RIRGIALPGPLRRLSEGIALLITTGFLPQRFRDEMRLPWDATKQRRFDALMAVLRTVN
RLMPRFVREFPFNLMLWDLDRRMRRGRPLV"
gene complement(332708..333136)
/gene="vapC25"
/locus_tag="Rv0277c"
CDS complement(332708..333136)
/codon_start=1
/transl_table=11
/gene="vapC25"
/locus_tag="Rv0277c"
/product="Possible toxin VapC25. Contains PIN domain."
/note="Rv0277c, (MTV035.05c), len: 142 aa. Possible
vapC25,toxin, part of toxin-antitoxin (TA) operon with
Rv0277A,contains PIN domain, see Arcus et al. 2005. Highly
similar to others e.g.
Rv0749|H70824|2911023|CAA17516.1|AL021958 conserved
hypothetical protein from Mycobacterium tuberculosis (142
aa); and Rv2530c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0277c"
/db_xref="EnsemblGenomes-Tr:CCP43006"
/db_xref="GOA:P9WF85"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF85"
/protein_id="CCP43006.1"
/translation="MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVW
ASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHLPTSPGPRHLVLLRKLCDEADAS
GDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI"
gene complement(333160..333417)
/pseudo
/gene="vapB25"
/locus_tag="Rv0277A"
CDS complement(333160..333417)
/codon_start=1
/transl_table=11
/gene="vapB25"
/locus_tag="Rv0277A"
/product="Possible antitoxin VapB25"
/note="Rv0277A, len: 85 aa. Possible vapB25,
antitoxin,part of toxin-antitoxin (TA) operon with
Rv0277c, see Arcus et al. 2005. Has in-frame stop codon so
may not be expressed. Very similar to others in
Mycobacterium tuberculosis e.g. Rv0748 (85 aa). Fasta
score E(): 4e-24; 88.2% identity in 85 aa overlap"
/pseudogene="unknown"
gene complement(333437..336310)
/gene="PE_PGRS3"
/locus_tag="Rv0278c"
CDS complement(333437..336310)
/codon_start=1
/transl_table=11
/gene="PE_PGRS3"
/locus_tag="Rv0278c"
/product="PE-PGRS family protein PE_PGRS3"
/note="Rv0278c, (MTV035.06c), len: 957 aa. PE_PGRS3,
Member of the Mycobacterium tuberculosis PE family (see
citation below), PGRS subfamily of gly-rich proteins,
similar to many e.g. Z95890|MTCY28_25|Rv1759c from
Mycobacterium tuberculosis (914 aa), FASTA scores: opt:
3849, E(): 0,(67.8% identity in 903 aa overlap). Contains
PS00583 pfkB family of carbohydrate kinases signature 1."
/db_xref="EnsemblGenomes-Gn:Rv0278c"
/db_xref="EnsemblGenomes-Tr:CCP43008"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIG3"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43008.1"
/translation="MSFVIAAPEVIAAAATDLASLGSSISAANAAAAANTTALMAAGA
DEVSTAIAALFGAHGQAYQALSAQAQAFHAQFVQALTSGGGAYAAAEAAAVSPLLDPI
NEFFLANTGRPLIGNGANGAPGTGANGGDGGWLIGNGGAGGSGAAGVNGGAGGNGGAG
GNGGAGGLIGNGGAGGAGGVASSGIGGSGGAGGNAMLFGAGGAGGAGGGVVALTGGAG
GAGGAGGNAGLLFGAAGVGGAGGFTNGSALGGAGGAGGAGGLFATGGVGGSGGAGSSG
GAGGAGGAGGLFGAGGTGGHGGFADSSFGGVGGAGGAGGLFGAGGEGGSGGHSLVAGG
DGGAGGNAGMLALGAAGGAGGIGGDGGTLTAGGIGGAGGAGGNAGLLFGSGGSGGAGG
FGFADGGQGGPGGNAGTVFGSGGAGGNGGVGQGFAGGIGGAGGTPGLIGNGGNGGNGG
ASAVTGGNGGIGGTGVLIGNGGNGGSGGIGAGKAGVGGVSGLLLGLDGFNAPASTSPL
HTLQQNVLNVVNEPFQTLTGRPLIGNGANGTPGTGADGGAGGWLFGNGANGTPGTGAA
GGAGGWLFGNGGNGGHGATNTAATATGGAGGAGGILFGTGGNGGTGGIATGAGGIGGA
GGAGGVSLLIGSGGTGGNGGNSIGVAGIGGAGGRGGDAGLLFGAAGTGGHGAAGGVPA
GVGGAGGNGGLFANGGAGGAGGFNAAGGNGGNGGLFGTGGTGGAGTNFGAGGNGGNGG
LFGAGGTGGAAGSGGSGITTGGGGHGGNAGLLSLGASGGAGGSGGASSLAGGAGGTGG
NGALLFGFRGAGGAGGHGGAALTSIQQGGAGGAGGNGGLLFGSAGAGGAGGSGANALG
AGTGGTGGDGGHAGVFGNGGDGGCRRVWRRYRRQRWCRRQRRADRQRRQRRQRRQSRG
HARCRRHRRAAARRERTQRLAIAGRPATTRGVEGISCSPQMMP"
gene complement(336560..339073)
/gene="PE_PGRS4"
/locus_tag="Rv0279c"
CDS complement(336560..339073)
/codon_start=1
/transl_table=11
/gene="PE_PGRS4"
/locus_tag="Rv0279c"
/product="PE-PGRS family protein PE_PGRS4"
/note="Rv0279c, (MTV035.07c), len: 837 aa. PE_PGRS4,
Member of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan and Delogu,
2002),similar to many e.g. Z95890|MTCY28_25|Rv0278c from
Mycobacterium tuberculosis (914 aa), FASTA scores: opt:
2677, E(): 0, (64.5% identity in 926 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0279c"
/db_xref="EnsemblGenomes-Tr:CCP43009"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L0T4W6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43009.1"
/translation="MSFVIAAPEVIAAAATDLASLESSIAAANAAAAANTTALLAAGA
DEVSTAVAALFGAHGQAYQALSAQAQAFHAQFVQALTSGGGAYAAAEAAATSPLLAPI
NEFFLANTGRPLIGNGTNGAPGTGANGGDGGWLIGNGGAGGSGAAGVNGGAGGNGGAG
GLIGNGGAGGAGGRASTGTGGAGGAGGAAGMLFGAAGVGGPGGFAAAFGATGGAGGAG
GNGGLFADGGVGGAGGATDAGTGGAGGSGGNGGLFGAGGTGGPGGFGIFGGGAGGDGG
SGGLFGAGGTGGSGGTSIINVGGNGGAGGDAGMLSLGAAGGAGGSGGSNPDGGGGAGG
IGGDGGTLFGSGGAGGVCGLGFDAGGAGGAGGKAGLLIGAGGAGGAGGGSFAGAGGTG
GAGGAPGLVGNAGNGGNGGASANGAGAAGGAGGSGVLIGNGGNGGSGGTGAPAGTAGA
GGLGGQLLGRDGFNAPASTPLHTLQQQILNAINEPTQALTGRPLIGNGANGTPGTGAD
GGAGGWLFGNGGNGGHGATGADGGDGGSGGAGGILSGIGGTGGSGGIGTTGQGGTGGT
GGAALLIGSGGTGGSGGFGLDTGGAGGRGGDAGLFLGAAGTGGQAALSQNFIGAGGTA
GAGGTGGLFANGGAGGAGGFGANGGTGGNGLLFGAGGTGGAGTLGADGGAGGHGGLFG
AGGTGGAGGSSGGTFGGNGGSGGNAGLLALGASGGAGGSGGSALNVGGTGGVGGNGGS
GGSLFGFGGAGGTGGSSGIGSSGGTGGDGGTAGVFGNGGDGGAGGFGADTGGNSSSVP
NAVLIGNGGNGGNGGKAGGTPGAGGTSGLIIGENGLNGL"
gene 339364..340974
/gene="PPE3"
/locus_tag="Rv0280"
CDS 339364..340974
/codon_start=1
/transl_table=11
/gene="PPE3"
/locus_tag="Rv0280"
/product="PPE family protein PPE3"
/note="Rv0280, (MTV035.08), len: 536 aa. PPE3, Member of
the Mycobacterium tuberculosis PPE family, similar to
others e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium
tuberculosis (539 aa), FASTA scores: opt: 1131, E():
0,(51.7% identity in 540 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0280"
/db_xref="EnsemblGenomes-Tr:CCP43010"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI45"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43010.1"
/translation="MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAEYAAVAD
ELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAAARHETVAAAYTTAV
AAMPTLVELAANHTLHGVLVATNFFGINTIPIALNEADYARMWTQAASTMATYQAVAE
AAVASAPQTTPAPPILAAEAADDDHDHDHDHGGEPTPLDYLVAEILRIISGGRLIWDP
AEGTMNGIPFEDYTDAAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFD
YPTHIVQIVEALSQSPQLLAVALGSVISNLGAVTGFAGLSGLAGMQPAAIPALAPVAA
APSTLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPAPPPAPGAAGFGYPYAI
APPGIGFGSGMSASASAQRKAPQPDSAAAAAAAAAVRDQARARRRRRVTRRGYGDEFM
DMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLGFAGTARREAVADAAGMTTLAGDDFG
DGPTTPMVPGSWDPDRDAPGSAEPGDRG"
gene 340998..341906
/locus_tag="Rv0281"
CDS 340998..341906
/codon_start=1
/transl_table=11
/locus_tag="Rv0281"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv0281, (MTV035.09), len: 302 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), member of Mycobacterium tuberculosis
protein family that includes Rv0726c, Rv0731c, Rv3399,
Rv1729c,etc. MTCY31_23 (325 aa), FASTA scores: opt: 1386,
E(): 0,(69. 1% identity in 301 aa overlap). Contains
possible N-terminal signal sequence."
/db_xref="EnsemblGenomes-Gn:Rv0281"
/db_xref="EnsemblGenomes-Tr:CCP43011"
/db_xref="GOA:P9WFI9"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFI9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43011.1"
/translation="MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAF
CRAVGGSWADVLDGKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAAAAGARQVVI
LAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHGAQPRALRREIAVDLRDDW
PQALRDSGFDAAAPSAWIAEGLLIYLPATAQERLFTGIDALAGRRSHVAVEDGAPMGP
DEYAAKVEEERAAIAEGAEEHPFFQLVYNERCAPAAEWFGERGWTAVATLLNDYLEAV
GRPVPGPESEAGPMFARNTLVSAARV"
gene 342130..344025
/gene="eccA3"
/locus_tag="Rv0282"
CDS 342130..344025
/codon_start=1
/transl_table=11
/gene="eccA3"
/locus_tag="Rv0282"
/product="ESX conserved component EccA3. ESX-3 type VII
secretion system protein."
/note="Rv0282, (MTV035.10), len: 631 aa. eccA3, esx
conserved component, ESX-3 type VII secretion system
protein, similar to Y14967|MLCB628.18c hypothetical
protein from Mycobacterium leprae (573 aa), FASTA scores:
opt: 916,E(): 0, (38.7% identity in 568 aa overlap). Also
similar to Mycobacterium tuberculosis proteins e.g.
Z94121|MTY15F10.26 (619 aa), FASTA scores: opt: 743, E():
0, (29.9% identity in 612 aa overlap). Member of CFXQ,
CBXP family - 9 members in Mycobacterium tuberculosis.
Contains PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0282"
/db_xref="EnsemblGenomes-Tr:CCP43012"
/db_xref="GOA:P9WPI3"
/db_xref="InterPro:IPR000641"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR023835"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041627"
/db_xref="UniProtKB/Swiss-Prot:P9WPI3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43012.1"
/translation="MAGVGEGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFATC
CRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQSIGVLEAASRT
ATTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFHLAYAAALASTGGPEEFAKA
NHVVSGITERRAGWRAARWLAVVINYRAERWSDVVKLLTPMVNDPDLDEAFSHAAKIT
LGTALARLGMFAPALSYLEEPDGPVAVAAVDGALAKALVLRAHVDEESASEVLQDLYA
AHPENEQVEQALSDTSFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALL
HEAELQLAEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGKT
TIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEA
YALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTR
NIDFPSYTSHELVEIAHKMAEQRDSVFEQSALHDLEALFAKLAAESTPDTNGISRRSL
DIAGNGRFVRNIVERSEEEREFRLDHSEHAGSGEFSDEELMTITADDVGRSVEPLLRG
LGLSVRA"
gene 344022..345638
/gene="eccB3"
/locus_tag="Rv0283"
CDS 344022..345638
/codon_start=1
/transl_table=11
/gene="eccB3"
/locus_tag="Rv0283"
/product="ESX conserved component EccB3. ESX-3 type VII
secretion system protein. Possible membrane protein."
/note="Rv0283, (MTV035.11), len: 538 aa. eccB3, esx
conserved component, ESX-3 type VII secretion system
protein, possible membrane protein, similar to several
hypothetical mycobacterial proteins e.g.
Z94121|MTY15F10_16|Rv3895c from Mycobacterium tuberculosis
(495 aa), FASTA scores: opt: 698, E(): 0, (37.6% identity
in 492 aa overlap); Rv1782; Rv3450c; Rv3869; and
Y14967|MLCB628_16|MLCB628.17c from Mycobacterium leprae
(481 aa), FASTA scores: opt: 672, E(): 1.5e-31, (37.2%
identity in 506 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0283"
/db_xref="EnsemblGenomes-Tr:CCP43013"
/db_xref="GOA:P9WNR3"
/db_xref="InterPro:IPR007795"
/db_xref="InterPro:IPR042485"
/db_xref="UniProtKB/Swiss-Prot:P9WNR3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43013.1"
/translation="MTNQQHDHDFDHDRRSFASRTPVNNNPDKVVYRRGFVTRHQVTG
WRFVMRRIAAGIALHDTRMLVDPLRTQSRAVLMGVLIVITGLIGSFVFSLIRPNGQAG
SNAVLADRSTAALYVRVGEQLHPVLNLTSARLIVGRPVSPTTVKSTELDQFPRGNLIG
IPGAPERMVQNTSTDANWTVCDGLNAPSRGGADGVGVTVIAGPLEDTGARAAALGPGQ
AVLVDSGAGTWLLWDGKRSPIDLADHAVTSGLGLGADVPAPRIIASGLFNAIPEAPPL
TAPIIPDAGNPASFGVPAPIGAVVSSYALKDSGKTISDTVQYYAVLPDGLQQISPVLA
AILRNNNSYGLQQPPRLGADEVAKLPVSRVLDTRRYPSEPVSLVDVTRDPVTCAYWSK
PVGAATSSLTLLAGSALPVPDAVHTVELVGAGNGGVATRVALAAGTGYFTQTVGGGPD
APGAGSLFWVSDTGVRYGIDNEPQGVAGGGKAVEALGLNPPPVPIPWSVLSLFVPGPT
LSRADALLAHDTLVPDSRPARPVSAEGGYR"
gene 345635..349627
/gene="eccC3"
/locus_tag="Rv0284"
CDS 345635..349627
/codon_start=1
/transl_table=11
/gene="eccC3"
/locus_tag="Rv0284"
/product="ESX conserved component EccC3. ESX-3 type VII
secretion system protein. Possible membrane protein."
/note="Rv0284, (MTV035.12), len: 1330 aa. eccC3, esx
conserved component, ESX-3 type VII secretion system
protein, possible membrane protein, similar to products of
two adjacent Mycobacterium leprae genes, MLCB628.16c (744
aa) and MLCB628.15c (597 aa); and throughout its length to
several large Mycobacterium tuberculosis proteins:
Rv3447c,Rv3870, Rv1784, etc. Y14967|MLCB628_ 15 (744 aa),
FASTA scores: opt: 942, E(): 0, (33.8% identity in 730 aa
overlap); Y14967|MLCB628_14 (597 aa), FASTA scores: opt:
613, E(): 3.1e-30, (31.7% identity in 615 aa overlap);
Z94121|MTY15F10_17 (1396 aa), FASTA scores: opt: 652, E():
2.2e-32, (35.4% identity in 1321 aa overlap);
Z95389|MTCY77_19 (1236 aa), FASTA scores: opt 652, E():
2.2e-32, (35.4% identity in 1321 aa overlap). Contains
three PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0284"
/db_xref="EnsemblGenomes-Tr:CCP43014"
/db_xref="GOA:P9WNA9"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR023836"
/db_xref="InterPro:IPR023837"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNA9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43014.1"
/translation="MSRLIFEARRRLAPPSSHQGTIIIEAPPELPRVIPPSLLRRALP
YLIGILIVGMIVALVATGMRVISPQTLFFPFVLLLAATALYRGNDKKMRTEEVDAERA
DYLRYLSVVRDNIRAQAAEQRASALWSHPDPTALASVPGSRRQWERDPHDPDFLVLRA
GRHTVPLATTLRVNDTADEIDLEPVSHSALRSLLDTQRSIGDVPTGIDLTKVSPITVL
GERAQVRAVLRAWIAQAVTWHDPTVLGVALAARDLEGRDWNWLKWLPHVDIPGRLDAL
GPARNLSTDPDELIALLGPVLADRPAFTGQPTDALRHLLIVVDDPDYDLGASPLAVGR
AGVTVVHCSASAPHREQYSDPEKPILRVAHGAIERWQTGGWQPYIDAADQFSADEAAH
LARRLSRWDSNPTHAGLRSAATRGASFTTLLGIEDASRLDVPALWAPRRRDEELRVPI
GVTGTGEPLMFDLKDEAEGGMGPHGLMIGMTGSGKSQTLMSILLSLLTTHSAERLIVI
YADFKGEAGADSFRDFPQVVAVISNMAEKKSLADRFADTLRGEVARREMLLREAGRKV
QGSAFNSVLEYENAIAAGHSLPPIPTLFVVADEFTLMLADHPEYAELFDYVARKGRSF
RIHILFASQTLDVGKIKDIDKNTAYRIGLKVASPSVSRQIIGVEDAYHIESGKEHKGV
GFLVPAPGATPIRFRSTYVDGIYEPPQTAKAVVVQSVPEPKLFTAAAVEPDPGTVIAD
TDEQEPADPPRKLIATIGEQLARYGPRAPQLWLPPLDETIPLSAALARAGVGPRQWRW
PLGEIDRPFEMRRDPLVFDARSSAGNMVIHGGPKSGKSTALQTFILSAASLHSPHEVS
FYCLDYGGGQLRALQDLAHVGSVASALEPERIRRTFGELEQLLLSRQQREVFRDRGAN
GSTPDDGFGEVFLVIDNLYGFGRDNTDQFNTRNPLLARVTELVNVGLAYGIHVIITTP
SWLEVPLAMRDGLGLRLELRLHDARDSNVRVVGALRRPADAVPHDQPGRGLTMAAEHF
LFAAPELDAQTNPVAAINARYPGMAAPPVRLLPTNLAPHAVGELYRGPDQLVIGQREE
DLAPVILDLAANPLLMVFGDARSGKTTLLRHIIRTVREHSTADRVAFTVLDRRLHLVD
EPLFPDNEYTANIDRIIPAMLGLANLIEARRPPAGMSAAELSRWTFAGHTHYLIIDDV
DQVPDSPAMTGPYIGQRPWTPLIGLLAQAGDLGLRVIVTGRATGSAHLLMTSPLLRRF
NDLQATTLMLAGNPADSGKIRGERFARLPAGRAILLTDSDSPTYVQLINPLVDAAAVS
GETQQKGSQS"
gene 349624..349932
/gene="PE5"
/locus_tag="Rv0285"
CDS 349624..349932
/codon_start=1
/transl_table=11
/gene="PE5"
/locus_tag="Rv0285"
/product="PE family protein PE5"
/note="Rv0285, (MTV035.13), len: 102 aa. PE5, Member of
the Mycobacterium tuberculosis PE family (see Brennan &
Delogu 2002), similar to others e.g. AL0212|MTV012_37 from
Mycobacterium tuberculosis (105 aa), FASTA scores: opt:
497, E(): 2.6e-24, (80.4% identity in 102 aa overlap);
Z80108|MTCY21B4.03 from Mycobacterium tuberculosis (102
aa), FASTA scores: opt: 413, E(): 3.7e-19, (66.7% identity
in 102 aa overlap); etc. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0285"
/db_xref="EnsemblGenomes-Tr:CCP43015"
/db_xref="GOA:L7N695"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:L7N695"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43015.1"
/translation="MTLRVVPEGLAAASAAVEALTARLAAAHASAAPVITAVVPPAAD
PVSLQTAAGFSAQGVEHAVVTAEGVEELGRAGVGVGESGASYLAGDAAAAATYGVVGG
"
gene 349935..351476
/gene="PPE4"
/locus_tag="Rv0286"
CDS 349935..351476
/codon_start=1
/transl_table=11
/gene="PPE4"
/locus_tag="Rv0286"
/product="PPE family protein PPE4"
/note="Rv0286, (MTV035.14), len: 513 aa. PPE4, Member of
the Mycobacterium tuberculosis PPE family, similar to
others e.g. AL0212|MTV012_32 from Mycobacterium
tuberculosis (434 aa), FASTA scores: opt: 958, E():
0,(43.5% identity in 522 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0286"
/db_xref="EnsemblGenomes-Tr:CCP43016"
/db_xref="GOA:P9WI43"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI43"
/protein_id="CCP43016.1"
/translation="MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYAST
AAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTT
ALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAA
SGAALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQL
IWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSP
FLLPAGLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAG
AATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVP
AAAAAAATRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLG
FAGTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGL
PHDSK"
gene 351525..351818
/gene="esxG"
/gene_synonym="TB9.8"
/locus_tag="Rv0287"
CDS 351525..351818
/codon_start=1
/transl_table=11
/gene="esxG"
/gene_synonym="TB9.8"
/locus_tag="Rv0287"
/product="ESAT-6 like protein EsxG (conserved protein
TB9.8)"
/note="Rv0287, (MTV035.15), len: 97 aa. EsxG, ESAT-6 like
protein. PE-family related protein; distant member of the
Mycobacterium tuberculosis PE family, similar to
Rv3020c|AL0212|MTV012.34 (97 aa), FASTA scores: opt:
564,E(): 0, (91.8% identity in 97 aa overlap). Contains
probable helix-turn-helix motif at aa 14-35 (Score
144,+4.11 SD). Seems to belong to the ESAT6 family (see
Gey Van Pittius et al., 2001). Note that previously known
as TB9.8."
/db_xref="EnsemblGenomes-Gn:Rv0287"
/db_xref="EnsemblGenomes-Tr:CCP43017"
/db_xref="GOA:O53692"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:2KG7"
/db_xref="UniProtKB/Swiss-Prot:O53692"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43017.1"
/translation="MSLLDAHIPQLVASQSAFAAKAGLMRHTIGQAEQAAMSAQAFHQ
GESSAAFQAAHARFVAAAAKVNTLLDVAQANLGEAAGTYVAADAAAASTYTGF"
gene 351848..352138
/gene="esxH"
/gene_synonym="cfp7"
/gene_synonym="TB10.4"
/locus_tag="Rv0288"
CDS 351848..352138
/codon_start=1
/transl_table=11
/gene="esxH"
/gene_synonym="cfp7"
/gene_synonym="TB10.4"
/locus_tag="Rv0288"
/product="Low molecular weight protein antigen 7 EsxH (10
kDa antigen) (CFP-7) (protein TB10.4)"
/note="Rv0288, (MT0301, MTV035.16), len: 96 aa. EsxH, low
molecular weight protein antigen 7 (10 kDa antigen)
(CFP-7) (Protein TB10.4) (see citations below), ala-rich
protein; member of mycobacterial protein family containing
ESAT-6,very similar to MTV012_33 from Mycobacterium
tuberculosis (96 aa), FASTA scores: opt: 566, E(): 0,
(84.4% identity in 96 aa overlap). Alternative start codon
possible position 351878 (see Rosenkrands et al., 2000).
Belongs to the ESAT6 family (see Skjot et al., 2000; 2002;
Gey Van Pittius et al., 2001). Note that previously known
as cfp7 (alternate gene name: TB10.4). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004). Predicted possible vaccine
candidate (See Zvi et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0288"
/db_xref="EnsemblGenomes-Tr:CCP43018"
/db_xref="GOA:P9WNK3"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:2KG7"
/db_xref="UniProtKB/Swiss-Prot:P9WNK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43018.1"
/translation="MSQIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQ
GDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAMMARDTAEAAKWGG"
gene 352149..353036
/gene="espG3"
/locus_tag="Rv0289"
CDS 352149..353036
/codon_start=1
/transl_table=11
/gene="espG3"
/locus_tag="Rv0289"
/product="ESX-3 secretion-associated protein EspG3"
/note="Rv0289, (MTV035.17), len: 295 aa. EspG3, ESX-3
secretion-associated protein, equivalent to
CAC32061.1|AL583926 possible DNA-binding protein from
Mycobacterium leprae (289 aa); and showing some similarity
to Rv3866|G70656|CAB06238.1|Z94121|MTCY15F10.23 from
Mycobacterium tuberculosis (276 aa), FASTA scores: opt:
149, E(): 0.0035, (27.7% identity in 289 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0289"
/db_xref="EnsemblGenomes-Tr:CCP43019"
/db_xref="GOA:P9WJC7"
/db_xref="InterPro:IPR025734"
/db_xref="PDB:4W4I"
/db_xref="PDB:5XKL"
/db_xref="UniProtKB/Swiss-Prot:P9WJC7"
/protein_id="CCP43019.1"
/translation="MDATPNAVELTVDNAWFIAETIGAGTFPWVLAITMPYSDAAQRG
AFVDRQRDELTRMGLLSPQGVINPAVADWIKVVCFPDRWLDLRYVGPASADGACELLR
GIVALRTGTGKTSNKTGNGVVALRNAQLVTFTAMDIDDPRALVPILGVGLAHRPPARF
DEFSLPTRVGARADERLRSGVPLGEVVDYLGIPASARPVVESVFSGPRSYVEIVAGCN
RDGRHTTTEVGLSIVDTSAGRVLVSPSRAFDGEWVSTFSPGTPFAIAVAIQTLTACLP
DGQWFPGQRVSRDFSTQSS"
gene 353083..354501
/gene="eccD3"
/locus_tag="Rv0290"
CDS 353083..354501
/codon_start=1
/transl_table=11
/gene="eccD3"
/locus_tag="Rv0290"
/product="ESX conserved component EccD3. ESX-3 type VII
secretion system protein. Probable transmembrane protein."
/note="Rv0290, (MTV035.18), len: 472 aa. EccD3, esx
conserved component, ESX-3 type VII secretion system
protein, probable transmembrane protein, similar to
several others in mycobacteria e.g.
Z95389|MTCY77_20|Rv3887c from Mycobacterium tuberculosis
(467 aa), FASTA scores: opt: 429, E(): 5.1e-19, (28. 6%
identity in 479 aa overlap); Rv3877; Rv1795; Rv3448; and
Y14967|MLCB628_9|MLCB628.10c from Mycobacterium leprae
(480 aa), FASTA scores: opt: 269,E(): 3.1e-09, (26.0%
identity in 503 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0290"
/db_xref="EnsemblGenomes-Tr:CCP43020"
/db_xref="GOA:P9WNQ3"
/db_xref="InterPro:IPR006707"
/db_xref="InterPro:IPR024962"
/db_xref="UniProtKB/Swiss-Prot:P9WNQ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43020.1"
/translation="MSGTVMQIVRVAILADSRLTEMALPAELPLREILPAVQRLVVPS
AQNGDGGQADSGAAVQLSLAPVGGQPFSLDASLDTVGVVDGDLLVLQPVPAGPAAPGI
VEDIADAAMIFSTSRLKPWGIAHIQRGALAAVIAVALLATGLTVTYRVATGVLAGLLA
VAGIAVASALAGLLITIRSPRSGIALSIAALVPIGAALALAVPGKFGPAQVLLGAAGV
AAWSLIALMIPSAERERVVAFFTAAAVVGASVALAAGAQLLWQLPLLSIGCGLIVAAL
LVTIQAAQLSALWARFPLPVIPAPGDPTPSAPPLRLLEDLPRRVRVSDAHQSGFIAAA
VLLSVLGSVAIAVRPEALSVVGWYLVAATAAAATLRARVWDSAACKAWLLAQPYLVAG
VLLVFYTATGRYVAAFGAVLVLAVLMLAWVVVALNPGIASPESYSLPLRRLLGLVAAG
LDVSLIPVMAYLVGLFAWVLNR"
gene 354498..355883
/gene="mycP3"
/locus_tag="Rv0291"
CDS 354498..355883
/codon_start=1
/transl_table=11
/gene="mycP3"
/locus_tag="Rv0291"
/product="Probable membrane-anchored mycosin MycP3 (serine
protease) (subtilisin-like protease) (subtilase-like)
(mycosin-3)"
/note="Rv0291, (MTV035.19), len: 461 aa. Probable
mycP3,membrane-anchored serine protease (mycosin) (see
Brown et al., 2000), similar to several others in
mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from
Mycobacterium tuberculosis (446 aa), FASTA scores: opt:
1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c;
Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from
Mycobacterium leprae (446 aa), FASTA scores: opt: 1159,
E(): 0, (43.5 identity in 446 aa overlap). Has signal
sequence and hydrophobic stretch at C-terminus, followed
by short positively charged segment,that seems to act as a
membrane anchor. Contains PS00137 Serine proteases,
subtilase family, histidine active site signature. Belongs
to peptidase family S8 (also known as the subtilase
family), pyrolysin subfamily. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0291"
/db_xref="EnsemblGenomes-Tr:CCP43021"
/db_xref="GOA:O53695"
/db_xref="InterPro:IPR000209"
/db_xref="InterPro:IPR015500"
/db_xref="InterPro:IPR022398"
/db_xref="InterPro:IPR023834"
/db_xref="InterPro:IPR036852"
/db_xref="UniProtKB/Swiss-Prot:O53695"
/inference="protein motif:PROSITE:PS00137"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43021.1"
/translation="MIRAAFACLAATVVVAGWWTPPAWAIGPPVVDAAAQPPSGDPGP
VAPMEQRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQLVAIIDTGVQPGP
RLPNVDAGGDFVESTDGLTDCDGHGTLVAGIVAGQPGNDGFSGVAPAARLLSIRAMST
KFSPRTSGGDPQLAQATLDVAVLAGAIVHAADLGAKVINVSTITCLPADRMVDQAALG
AAIRYAAVDKDAVIVAAAGNTGASGSVSASCDSNPLTDLSRPDDPRNWAGVTSVSIPS
WWQPYVLSVASLTSAGQPSKFSMPGPWVGIAAPGENIASVSNSGDGALANGLPDAHQK
LVALSGTSYAAGYVSGVAALVRSRYPGLNATEVVRRLTATAHRGARESSNIVGAGNLD
AVAALTWQLPAEPGGGAAPAKPVADPPVPAPKDTTPRNVAFAGAAALSVLVGLTAATV
AIARRRREPTE"
gene 355880..356875
/gene="eccE3"
/locus_tag="Rv0292"
CDS 355880..356875
/codon_start=1
/transl_table=11
/gene="eccE3"
/locus_tag="Rv0292"
/product="ESX conserved component EccE3. ESX-3 type VII
secretion system protein. Probable transmembrane protein."
/note="Rv0292, (MTV035.20), len: 331 aa. EccE3, esx
conserved component, ESX-3 type VII secretion system
protein, probable transmembrane protein (has two
hydrophobic segments at N-terminal end), equivalent to
CAC32058.1|AL583926 conserved membrane protein from
Mycobacterium leprae (339 aa). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0292"
/db_xref="EnsemblGenomes-Tr:CCP43022"
/db_xref="GOA:P9WJE5"
/db_xref="InterPro:IPR021368"
/db_xref="UniProtKB/Swiss-Prot:P9WJE5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43022.1"
/translation="MNPIPSWPGRGRVTLVLLAVVPVALAYPWQSTRDYVLLGVAAAV
VIGLFGFWRGLYFTTIARRGLAILRRRRRIAEPATCTRTTVLVWVGPPASDTNVLPLT
LIARYLDRYGIRADTIRITSRVTASGDCRTWVGLTVVADDNLAALQARSARIPLQETA
QVAARRLADHLREIGWEAGTAAPDEIPALVAADSRETWRGMRHTDSDYVAAYRVSANA
ELPDTLPAIRSRPAQETWIALEIAYAAGSSTRYTVAAACALRTDWRPGGTAPVAGLLP
QHGNHVPALTALDPRSTRRLDGHTDAPADLLTRLHWPTPTAGAHRAPLTNAVSRT"
gene complement(356862..358064)
/locus_tag="Rv0293c"
CDS complement(356862..358064)
/codon_start=1
/transl_table=11
/locus_tag="Rv0293c"
/product="Conserved protein"
/note="Rv0293c, (MTV035.21c), len: 400 aa. Conserved
protein, similar in C-terminal part to
Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 conserved
hypothetical protein from Mycobacterium tuberculosis (413
aa), FASTA scores: opt: 394, E(): 2.1e-17, (31.1% identity
in 299 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0293c"
/db_xref="EnsemblGenomes-Tr:CCP43023"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53697"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43023.1"
/translation="MSGTFTADAIGPPVPIPDVPGADAGAEGLPSRSVLSARQRILVE
SSAIADVALRTAVASVLSATVTPAVVANALRHVNEGSERSNLNFYAELAAAHDPAKSF
PAPTELPKVTSRPASPLTEWVARGTVDNIAFASGFRAINPTMRQRWSALTANNIVHAQ
HWRHRDGPRPTLCVIHGFMGSSYLLNGLFFSLPWYYRSGYDVLLYTLPFHGQRAEKFS
PFSGFGYFTSGLSGFAEAMAQAVYDFRSIVDYLRHIGVDRIALTGISLGGYTSALLAS
VESRLEAVIPNCPVVMPAKLFDEWFPANKLVKLGLRLTNISRDELIAGLAYHGPLNYR
PLLPKDRRMIITGLGDRMAPPEHAVTLWKQWDRCALHWFPGSHLLHVSQLDYLRRMTV
FLQGLMFD"
gene 358171..358956
/gene="tam"
/locus_tag="Rv0294"
CDS 358171..358956
/codon_start=1
/transl_table=11
/gene="tam"
/locus_tag="Rv0294"
/product="Probable trans-aconitate methyltransferase Tam"
/note="Rv0294, (MTV035.22), len: 261 aa. Probable
tam,trans-aconitate methyltransferase, similar to others
e.g. P76145|TAM_ECOLI|7465793|B64906|B1519 trans-aconitate
methyltransferase from Escherichia coli strain K12 (252
aa), FASTA scores: opt: 649, E(): 0, (39.3 identity in 252
aa overlap). Belongs to the methyltransferase
superfamily."
/db_xref="EnsemblGenomes-Gn:Rv0294"
/db_xref="EnsemblGenomes-Tr:CCP43024"
/db_xref="GOA:P9WGA3"
/db_xref="InterPro:IPR023149"
/db_xref="InterPro:IPR023506"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WGA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43024.1"
/translation="MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLT
RYLARRWPGAVIEALDSSPEMVAAAAERGIDATTGDLRDWKPKPDTDVVVSNAALHWV
PEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRALARREPYAKLMRDIPFRVGA
VVQSPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRERLSDESWQ
QFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG"
gene complement(358945..359748)
/locus_tag="Rv0295c"
CDS complement(358945..359748)
/codon_start=1
/transl_table=11
/locus_tag="Rv0295c"
/product="Conserved protein"
/note="Rv0295c, (MTV035.23c), len: 267 aa. Conserved
protein, showing weak similarity with CAC46877.1|AL591790
conserved hypothetical protein from Sinorhizobium meliloti
(213 aa); and NP_104818.1|14023999|BAB50604.1|AP00300
Protein with weak similarity to NodH from Mesorhizobium
loti (257 aa). Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0295c"
/db_xref="EnsemblGenomes-Tr:CCP43025"
/db_xref="GOA:O53699"
/db_xref="InterPro:IPR015124"
/db_xref="InterPro:IPR024628"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:O53699"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43025.1"
/translation="MSRAVRPYLVLATQRSGSTLLVESLRATGCAGEPQEFFQYLPST
GMAPQPREWFAGVDDDTILQLLDPLDPGTPDTATPVAWREHVRTSGRTPNGVWGGKLM
WNQTALLQQRAAQLPDRSGDGLRAAIRDVIGNEPVFVHVHRPDVVSQAVSFWRAVQTQ
VWRGHPDPKRDSQAVYHAGAIAHIIRNLRDQENGWRAWFAEEGIDPIDIAYPVLWRNL
TAIVASVLDAIGQDPKLAPAPMLERQANQRSDEWVDRYRAEAPRLGLPT"
gene complement(359758..361155)
/gene_synonym="atsG"
/locus_tag="Rv0296c"
CDS complement(359758..361155)
/codon_start=1
/transl_table=11
/gene_synonym="atsG"
/locus_tag="Rv0296c"
/product="Probable sulfatase"
/note="Rv0296c, (MTCY63.01c, MTV035.24c), len: 465 aa.
Probable sulfatase, possibly an aryl-/steryl-sulfatase or
a sulfamidase (sulfohydrolase) (sulphamidase). Similar to
various hydrolases e.g. AAG41945.1|AF304053_1|AF304053
heparan N-sulfatase from Mus musculus (502 aa);
NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827
N-sulfoglucosamine sulfohydrolase (sulfamidase)
(sulphamidase) from Mus musculus (502 aa);
AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase
from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652
steryl-sulfatase precursor (steroid sulfatase)
(steryl-sulfate sulfohydrolase) (arylsulfatase C) (ASC)
from Homo sapiens (583 aa); ARSB_FELCA|P33727
arylsulfatase B precursor (535 aa), FASTA scores: opt:
231, E(): 1.7e-08,(30.3% identity in 261 aa overlap). Also
similarity with 4 others sulfatases in Mycobacterium
tuberculosis. Contains sulfatases signature 1 (PS00523).
Note that previously known as atsG."
/db_xref="EnsemblGenomes-Gn:Rv0296c"
/db_xref="EnsemblGenomes-Tr:CCP43026"
/db_xref="GOA:Q6MX51"
/db_xref="InterPro:IPR000917"
/db_xref="InterPro:IPR017850"
/db_xref="InterPro:IPR024607"
/db_xref="UniProtKB/TrEMBL:Q6MX51"
/inference="protein motif:PROSITE:PS00523"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43026.1"
/translation="MTSERATGQRENLLIVHWHDLGRYLGVYHHPDVYSPRLDRLAAE
GILFTRAHATAPLCTPSRGSLFTGRYPQSNGLVGLAHHGWEYRTGVQTLPQLLSESGW
YSALFGMQHETSYPKRLGFDEFDVSNSYCEYVVAKAQDWLHNRVPALDGQRFLLTAGF
FETHRPYPHERYRPADSAAVELPDYLPDTPEVRQDVAEFYGSIATADEAVGRLLDTLA
DTGLDASTWVVFVTDHGPAFPRAKSTLYDAGTGIALIIRPPTRRAMAPRVYDELFSGV
DLVPTLLDLLRLEVPADVEGVSHAPALLAPDTENAAVRDHVYTAKTYHDSFDPIRAIR
TKEYSYIENYAPRPLLDLPWDIQESPAGMAVAPLVKAPRPQRELYDLRADPTETNNLL
AGDDSTQGVAAIAADLAVRLHDWRQRTADVIPSDFAGSRIAERYTETYLRIHRKTPTG
RSAIAADRGIDEHCS"
gene 361334..363109
/gene="PE_PGRS5"
/locus_tag="Rv0297"
CDS 361334..363109
/codon_start=1
/transl_table=11
/gene="PE_PGRS5"
/locus_tag="Rv0297"
/product="PE-PGRS family protein PE_PGRS5"
/note="Rv0297, (MTCY63.02), len: 591 aa. PE_PGRS5, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
highly similar to others e.g. Y03A_MYCTU|Q10637 from
Mycobacterium tuberculosis (603 aa), FASTA scores: opt:
1884, E(): 0,(53.7% identity in 635 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0297"
/db_xref="EnsemblGenomes-Tr:CCP43027"
/db_xref="GOA:Q6MX50"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:Q6MX50"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43027.1"
/translation="MSFVIAQPEMIAAAAGELASIRSAINAANAAAAAQTTGVMSAAA
DEVSTAVAALFSSHAQAYQAASAQAAAFHAQVVRTLTVDAGAYASAEAANAGPNMLAA
VNAPAQALLGRPLIGNGANGAPGTGQAGGDGGLLFGNGGNGGSGAPGQAGGAGGAAGF
FGNGGNGGDGGAGANGGAGGTAGWFFGFGGNGGAGGIGVAGINGGLGGAGGDGGNAGF
FGNGGNGGMGGAGAAGVNAVNPGLATPVTPAANGGNGLNLVGVPGTAGGGADGANGSA
IGQAGGAGGDGGNASTSGGIGIAQTGGAGGAGGAGGDGAPGGNGGNGGSVEHTGATGS
SASGGNGATGGNGGVGAPGGAGGNGGHVSGGSVNTAGAGGKGGNGGTGGAGGPGGHGG
SVLSGPVGDSGNGGAGGDGGAGVSATDIAGTGGRGGNGGHGGLWIGNGGDGGAGGVGG
VGGAGAAGAIGGHGGDGGSVNTPIGGSEAGDGGKGGLGGDGGGRGIFGQFGAGGAGGA
GGVGGAGGAGGTGGGGGNGGAIFNAGTPGAAGTGGDGGVGGTGAAGGKGGAGGSGGVN
GATGADGAKGLDGATGGKGNNGNPG"
gene 363252..363479
/locus_tag="Rv0298"
CDS 363252..363479
/codon_start=1
/transl_table=11
/locus_tag="Rv0298"
/product="Hypothetical protein"
/note="Rv0298, (MTCY63.03), len: 75 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0298"
/db_xref="EnsemblGenomes-Tr:CCP43028"
/db_xref="GOA:P9WJ09"
/db_xref="InterPro:IPR002145"
/db_xref="UniProtKB/Swiss-Prot:P9WJ09"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43028.1"
/translation="MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRV
ALRDYTAKTVPALDIDAYAQRVYQANRAAGS"
gene 363476..363778
/locus_tag="Rv0299"
CDS 363476..363778
/codon_start=1
/transl_table=11
/locus_tag="Rv0299"
/product="Hypothetical protein"
/note="Rv0299, (MTCY63.04), len: 100 aa. Hypothetical
unknown protein. Equivalent to AAK44536.1 from
Mycobacterium tuberculosis strain CDC1551 (49 aa) but
longer 51 aa. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0299"
/db_xref="EnsemblGenomes-Tr:CCP43029"
/db_xref="GOA:O07226"
/db_xref="UniProtKB/Swiss-Prot:O07226"
/protein_id="CCP43029.1"
/translation="MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGR
VPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPLGNAGVAALREAASVVTALLC"
gene 363826..364047
/gene="vapB2"
/locus_tag="Rv0300"
CDS 363826..364047
/codon_start=1
/transl_table=11
/gene="vapB2"
/locus_tag="Rv0300"
/product="Possible antitoxin VapB2"
/note="Rv0300, (MTCY63.05), len: 73 aa. Possible
vapB2,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0301 (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Weak similarity with others e.g. Rv3697c from
Mycobacterium tuberculosis (145
aa),Rv1721c|MTCY04C12.06c|Z81360|MTCY4C12_4 conserved
hypothetical protein from Mycobacterium tuberculosis (75
aa), FASTA scores: opt: 84, E(): 8.3, (39.5% identity in
38 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0300"
/db_xref="EnsemblGenomes-Tr:CCP43030"
/db_xref="GOA:O07227"
/db_xref="InterPro:IPR002145"
/db_xref="InterPro:IPR010985"
/db_xref="InterPro:IPR013321"
/db_xref="PDB:3H87"
/db_xref="UniProtKB/Swiss-Prot:O07227"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43030.1"
/translation="MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTAR
VTVTAADLRRLRGAVAGLGDPELMRQAWR"
gene 364044..364469
/gene="vapC2"
/locus_tag="Rv0301"
CDS 364044..364469
/codon_start=1
/transl_table=11
/gene="vapC2"
/locus_tag="Rv0301"
/product="Possible toxin VapC2"
/note="Rv0301, (MTCY63.06), len: 141 aa. Possible
vapC2,toxin, part of toxin-antitoxin (TA) operon with
Rv0300,contains PIN domain (See Arcus et al., 2005; Pandey
and Gerdes, 2005). Similar to others in Mycobacterium
tuberculosis e.g. Rv2757c, Rv0229c, Rv2546, etc. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0301"
/db_xref="EnsemblGenomes-Tr:CCP43031"
/db_xref="GOA:P9WFB9"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="PDB:3H87"
/db_xref="UniProtKB/Swiss-Prot:P9WFB9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43031.1"
/translation="MTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEV
GFSAECGEIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLLI
AATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA"
gene 364605..365237
/locus_tag="Rv0302"
CDS 364605..365237
/codon_start=1
/transl_table=11
/locus_tag="Rv0302"
/product="Probable transcriptional regulatory protein
(probably TetR/AcrR-family)"
/note="Rv0302, (MTCY63.07), len: 210 aa. Probable
transcription regulatory protein, TetR family (see
citation below), with its N-terminus similar to N-terminus
of several repressors and regulatory proteins of TetR/AcrR
family e.g. ACRR_ECOLI|P34000 potential acraB operon
repressor from Escherichia coli (215 aa), FASTA scores:
opt: 172, E(): 3.1e-05, (22.7% identity in 194 aa
overlap). Also similar in N-terminus to N-terminus of
MTCY07A7.24 hypothetical regulator from Mycobacterium
tuberculosis FASTA score: (38.7% identity in 62 aa
overlap). Contains probable helix-turn helix motif from aa
35-56 (Score 1728,+5.07 SD). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0302"
/db_xref="EnsemblGenomes-Tr:CCP43032"
/db_xref="GOA:O07229"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR039538"
/db_xref="PDB:5D18"
/db_xref="PDB:5D19"
/db_xref="UniProtKB/TrEMBL:O07229"
/protein_id="CCP43032.1"
/translation="MGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDIRDAC
GLAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQ
SQHPDFLRLFYLLSMERSQDPAVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLV
VAELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET"
gene 365234..366142
/locus_tag="Rv0303"
CDS 365234..366142
/codon_start=1
/transl_table=11
/locus_tag="Rv0303"
/product="Probable dehydrogenase/reductase"
/note="Rv0303, (MTCY63.08), len: 302 aa. Possible
dehydrogenase/reductase, similar to various NADPH
dehydrogenases and other NADPH oxidoreductases e.g.
O48741|PORC_ARATH|7488284|T00897 protochlorophyllide
reductase C chloroplast precursor
(NADPH-protochlorophyllide oxidoreductase C) from
Arabidopsis thaliana (401 aa); Q42850 NADPH dehydrogenase
(395 aa), FASTA scores: opt: 347, E(): 3.8e-16, (35.4%
identity in 319 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0303"
/db_xref="EnsemblGenomes-Tr:CCP43033"
/db_xref="GOA:O07230"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O07230"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43033.1"
/translation="MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRA
AMEELGEPNRCSVLEVDLASVRSVRSFVETVRTTPLPPIRALVCNAGLQVVSGIAFTD
DGVEMTFGVNHLGHFALVTGILDWLARPARIVVVSSGTHDPSKHTGMPDPRYTCAADL
AHPPTDQNTPAEGRRRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLA
RDYPPILRLAYRLLSPMLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIR
SSAESYDRAKALDLWETSERLLAQVT"
gene complement(366150..372764)
/gene="PPE5"
/locus_tag="Rv0304c"
CDS complement(366150..372764)
/codon_start=1
/transl_table=11
/gene="PPE5"
/locus_tag="Rv0304c"
/product="PPE family protein PPE5"
/note="Rv0304c, (MTCY63.9c), len: 2204 aa. PPE5, Member of
the Mycobacterium tuberculosis PE family (PPE,
MPTR),similar to others e.g. Z95324|MTY13E10_16 from
Mycobacterium tuberculosis (1443 aa), FASTA scores: E():
0,(50.6% identity in 1403 aa overlap); Y04H_MYCTU|Q10778
from Mycobacterium tuberculosis (734 aa), FASTA scores:
opt: 989, E(): 0, (42.3% identity in 522 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0304c"
/db_xref="EnsemblGenomes-Tr:CCP43034"
/db_xref="InterPro:IPR002989"
/db_xref="UniProtKB/TrEMBL:Q6MX49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43034.1"
/translation="MNLVSTTSGMSGFLNVGALGSGVANVGNTISGIYNVGTSDLSTP
AVNSGLANIGTNIAGLLRDGAGTAAINLGLANHGNLNVGFASLGGFNFGGATIGHNNV
GIGNTGIFDVGLANLGSYNIGFGNLGDDNLGFGNFGSYNIGFGNVGNDNLGFANAGGG
NIGFANTGSNNVGFGNTGSNNVGIGLTGNGQIGFGSFNSGSGNIGLFNSGSNNIGFFN
SGSGNFGIANSGSFNTGIGNTGNTNTGLFNSGDVNTGAFNPGSFNTGSFNTGSFNTGG
FNPGNTNTGYLNIGNYNTGIANTGDVDTGAFITGNYSNGLFLSGDYQGLVGLNLVIDM
PLPISLGVNIPIDIPITASAGNITLMGVTIPPTGDIVLSSIAGQRAHFGPITIPNITV
VGPTTTVAIGGPNTAITITGGGAIRIPLISIPAAPGFGNSTTNPSSGFFNTGAGGASG
FGNFGGANSGFWNLASATSGASGLLNVGALGSGLANVGTTVSGFYNTSTSDLATPAFN
SGLANISTSIAGLLRDSTGTMVLNLGLANHGTLNVGIANLGDYNIGFANLGSANFGSA
NIGGNNIGGANTGIFDIGLANLGSYNIGFGNFGDDNLGFGNLGSYNVGFGNLGNDNLG
FANTGSNNIGFANTGSNNIGIGLTGDGQIGFGSLNSGSGNIGLFNSGSGNIGFFNSGN
GNVGIGNTGTANFGLGNTGSTNTGFFNSGDVNTGIGNTGSFNTGSFNPGDSNTGDFNP
GSYNTGLGNTGDVDTGAFISGSYSNGFLWSGNYQGLIGLHAALAIPEIALTFGVDIPI
HIPINIDAGVVTLQGFSIVAAENNIDFTPIIIPTINITLPTAAITVGGPTTSIGITAS
AGIGSITIPIIDIPATSGFGNSTTSPSSGFFNSGAGSASGFLNVVAGASGISGYLNVG
ALGSGVTNVGHTVSGFYNASALDLVTPAFASGLMRDGMGTMTLNLGLANLGSNNAGFG
NTGIFDVGVANLGNYNIGFGNFGDDNLGFANLGSYNIGVANTGSNNIGFANTGSNNIG
IGLTGTGQIGIGALNSGSGNIGLFNSGDGNIGFFNSGTGNFGIGNTGTGNFGIGNSGS
TSTGLFNSGDGNTGGFNPGNFNTGNFNTGSFNTGGFNAGNTNTGHFNTGNYNTGIANT
GDVSTGAFISGNYSNGILWRGDYQGLIGYSYALTIPEIPAHLDVNIPIDIPITGSFTD
LVVDNFTIPIIGFESFAFSFHIHTEPDIGPIIVPSFVLSVPTFAIAVGGPTTAINISA
TAGLGPITIPIIDIPAAPGIGNSTTSPSSGFFNTGAGTASGFGNVGGNTSGLWNLASA
ASGVSGLLNVGALGSGVANVGNTISGIYNTSPLDLGTPAFGSGLANIAGLLQGGAGTT
ILDLAGLGNLNVGLANLGGSNFGIGNTGIFNVGFANVGNHNIGLANLGNYSVGFANSG
NYHIGIANTGSANIGFANTGSGNIGIGLTGTGQIGFGSFNSGSHNIGLFNSGDGNVGF
FNSGTGNVGIGNTGTANFGIANSGSFNTGLGNTGSTNTGLFNPGNVNTGVGNTGSINT
GSINTGSFNTGSTNTGSFNLGDHNTGSFNSGDYNTGYFNAGDYNTGVANTGNVNTGAF
ISGNYSNGFFWRGDYQGLIGLSTTITIPEIPYRYDLSVPIDIPITGTVVATTPNSFTI
PGFQIRVLLGPAAVLVNEMIGPITIDVNQVIAIDSPIQQTISMVGTGGFGPIPIGISI
GGTPGFGNSTTGPSSGFFHTGAGHVSGFGNFGAGNMSGSGNFGAGNSGFFNAGGLGNS
GLLNFGALQSGLANLGNTISGVYNTSTLDLATPAFGSGIANIGANLAGLFLDNTGNLT
LNFGVANQGGLNAGIGNLGSVNIGFVNTGDSNLGIGNLGDLNFGGVNIGGNNIGIANT
GIFDIGLANLGSYNIGLANLGDDNLGFGNAGSYNIGFANFGSDNLGFANTGSYNIGFA
NTGNNNIGVGLTGNGQIGIGSLNSGSNNIGLFNSGSGNIGFFNSGTGNVGIFNTGTGN
FGLANSGGFNTGIGNAGSTNTGVFNPGDLNTGSFNPGSFNTGGFNPGSGNTGYLNTGD
YNTGVANTGDVDTGAFITGSYSNGFLVSGDYQGLIGLPLLGIPVTPGYFNLTGGPSSG
FFNSGAGSVSGFVNSGAGLSGYLNTGALGSGVANVGNTISGWLNASALDLATPGFLSG
IGNFGTNLAGFFRG"
gene complement(372820..375711)
/gene="PPE6"
/locus_tag="Rv0305c"
CDS complement(372820..375711)
/codon_start=1
/transl_table=11
/gene="PPE6"
/locus_tag="Rv0305c"
/product="PPE family protein PPE6"
/note="Rv0305c, (MTCY63.10c), len: 963 aa. PPE6, Member of
the Mycobacterium tuberculosis PE family (PPE,
MPTR),similar to others e.g. Y04H_MYCTU|Q10778 from
Mycobacterium tuberculosis (734 aa), FASTA scores: opt:
1340, E(): 0,(40.9% identity in 815 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0305c"
/db_xref="EnsemblGenomes-Tr:CCP43035"
/db_xref="GOA:Q6MX48"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q6MX48"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43035.1"
/translation="MDFVVSAPEVNSLRMYLGAGSGPMLAAAAAWDGLADELAVAASW
FGSVTSGLADAAWRGPAAVAMARAVAPYLGWLISATAQAEQAAAQARVAVATFEAARA
ATVHPAIVAANRAVLVSLVSSNLLGFNAPAIAATEAAYERMWAQDVAAMVGYHAGASA
AVSALMPFTQQLKKLAGLSERLTSAAAAAAGPPSAAGFNLGLANVGANNVGNGNVGVF
NVGFGNLGSYNLGFANLGSDNLGLANLGGHNIGFANTGSNNVGFGNTGSNNVGIGLTG
NGQIGFGSFNSGSHNIGLFNSGSGNVGLFNSGTGNFGIGNSGTGNFGLGNTGSTNTGW
FNTGDVNTGGFNPGSYNTGNFNTGNYNTGSFNAGNYNTGYFNTGDYNTGVANTGNVNT
GAFIAGNYSNGVLWRGDYQGLIGADIALEIPAIPINAQLFSMPIHQVMVMPGSVMTIP
GMRLPFTSIVPFVVYYGPVELPQSTLTLPTVTITVGGPTTTIDGNLTGMVGGVSIPLI
KIPAAPGFGNSTTSPSSGFFNAGAGTASGFGNFGGGASGFWNLASATSGLSGFGNVGA
LGSGVANVGNTISGLYNTSTSNLATPAFNSGLLHHSVGTMTLNFGLANVGGNNVGGAN
AGIFNVGLANLGDYNIGFGNLGGDNLGFAHAGSYNIGFANTGSNNLGFANTGDNNIGF
ANIGSNNIGIGLTGSGQIGFGSLNSGSHNIGLFNSGDGNIGLFNSGSGNFGIGNAGTG
NWGIGNSGAGNFGIGNAGSTNTGLFNSGDLNTGSLNPGSYNTGSVNTGSVNTGGFNAG
NYNTGYFNTGDLQHRHGEHRQYQHRRFHLRQPQQRPSVAGRQPGSDRPRHRRRHSRNP
DCERRREYPDSHTDHRQLHGHRIQRARSSTEHSRHCYFFRTRRYRPLHRPSDTDNRSH
TCGHGGWTHYRDQYRRHCGRRRHQHPDYPYSSDSRLRQLDRRTVVGLLQ"
gene 375914..376585
/locus_tag="Rv0306"
CDS 375914..376585
/codon_start=1
/transl_table=11
/locus_tag="Rv0306"
/product="Putative oxidoreductase"
/note="Rv0306, (MTCY63.11), len: 223 aa. Putative
oxidoreductase, highly similar to
H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved
hypothetical protein from Pseudomonas aeruginosa strain
PAO1 (218 aa); and to other putative oxidoreductases e.g.
middle part of CAB76073.1|AL157953 putative nitroreductase
from Streptomyces coelicolor (1212 aa); Q52685|BLUB
protein involved in cobalamin (vitamin B12) synthesis from
Rhodobacter capsulatus (206 aa), FASTA scores: opt:
318,E(): 2e-15, (35.6% identity in 191 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0306"
/db_xref="EnsemblGenomes-Tr:CCP43036"
/db_xref="GOA:O07233"
/db_xref="InterPro:IPR000415"
/db_xref="InterPro:IPR012825"
/db_xref="InterPro:IPR029479"
/db_xref="UniProtKB/TrEMBL:O07233"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43036.1"
/translation="MFSAPERRAVYRVIAERRDMRRFVPGGVVSEDVLARLLHAAHAA
PSVGLMQPWRFIRITDETLKRRIHALVDDERLLTAEALGAREEEFLALKVEGILDCAE
LLVVALCDRRGSYIFGRRTLPQMDLASVSCAIQNLWLAARSEGLGMGWVSLFDPQRLA
ALLAMPADAEPVAILCLGPVPEFPDRPALELDGWAYARPLAEFVSENRWSYPSALATD
HHHGE"
gene complement(376573..377055)
/locus_tag="Rv0307c"
CDS complement(376573..377055)
/codon_start=1
/transl_table=11
/locus_tag="Rv0307c"
/product="Unknown protein"
/note="Rv0307c, (MTCY63.12c), len: 160 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv0307c"
/db_xref="EnsemblGenomes-Tr:CCP43037"
/db_xref="UniProtKB/TrEMBL:O07234"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43037.1"
/translation="MAVIVRKWFGLGRLPADLRCQVEAEGLIYLAEYVAVTRRFTGVI
PGLRASHSIASYVGALAFTEQRVLGTLSMVPKLAGRVVDARWDGPQAGAATAEISPTG
LQLDLDVADVDPKFSGQLALHFKATIGEDVLSRLPRRSLAFDVPAEYVNLAVGVTYSP
"
gene 377113..377829
/locus_tag="Rv0308"
CDS 377113..377829
/codon_start=1
/transl_table=11
/locus_tag="Rv0308"
/product="Probable conserved integral membrane protein"
/note="Rv0308, (MTCY63.13), len: 238 aa. Probable
conserved integral membrane protein, with C-terminus
highly similar to C-terminus of other integral membrane
proteins or phosphatases e.g.
AAK25788.1|AF336822_1|13430250|AAK25789.1|AF336823_1
putative phosphatase from Streptococcus pyogenes (201 aa);
Q06074 hypothetical 24.9 kDa protein (216 aa), FASTA
scores: opt: 209, E(): 2e-07, (27.9% identity in 140 aa
overlap). Could be a phosphatase."
/db_xref="EnsemblGenomes-Gn:Rv0308"
/db_xref="EnsemblGenomes-Tr:CCP43038"
/db_xref="GOA:O07235"
/db_xref="InterPro:IPR000326"
/db_xref="InterPro:IPR036938"
/db_xref="UniProtKB/TrEMBL:O07235"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43038.1"
/translation="MTRPQALLAVSLAFVATAVYAVMWVGHSQDWGWLHSFDWSLLNA
AHDIGIKNPAWVRFWDGVSLILGPVVLRPLGLLAAMVALAKRKIRIALLLLACLPLNA
IMTIAAKSVAHRPRPATALVSAHSTSFPSGHALEATASVLALLTVLLPMLHSRFTRHI
AITVGALCVLTVGVARVALNVHHPTDVVAGWALGYLYFLVCLCVFRPPSIFGAQRASH
ALSPPVEVSRQPEPEVDTAR"
gene 377931..378587
/locus_tag="Rv0309"
CDS 377931..378587
/codon_start=1
/transl_table=11
/locus_tag="Rv0309"
/product="Possible conserved exported protein"
/note="Rv0309, (MTCY63.14), len: 218 aa. Possible
conserved exported protein (has putative N-terminal signal
sequence),equivalent to AC32053.1|AL583926 putative
secreted protein from Mycobacterium leprae (218 aa). Also
similar to others e.g. AB76092.1|AL157956 putative
secreted protein from Streptomyces coelicolor (238 aa).
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0309"
/db_xref="EnsemblGenomes-Tr:CCP43039"
/db_xref="GOA:O07236"
/db_xref="UniProtKB/TrEMBL:O07236"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43039.1"
/translation="MSRLLALLCAAVCTGCVAVVLAPVSLAVVNPWFANSVGNATQVV
SVVGTGGSTAKMDVYQRTAAGWQPLKTGITTHIGSAGMAPEAKSGYPATPMGVYSLDS
AFGTAPNPGGGLPYTQVGPNHWWSGDDNSPTFNSMQVCQKSQCPFSTADSENLQIPQY
KHSVVMGVNKAKVPGKGSAFFFHTTDGGPTAGCVAIDDATLVQIIRWLRPGAVIAIAK
"
gene complement(378657..379148)
/locus_tag="Rv0310c"
CDS complement(378657..379148)
/codon_start=1
/transl_table=11
/locus_tag="Rv0310c"
/product="Conserved protein"
/note="Rv0310c, (MTCY63.15c), len: 163 aa. Conserved
protein, similar to some bile acid dehydratases e.g.
P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489
bile acid-inducible operon protein E from Eubacterium sp
(166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8%
identity in 134 aa overlap); AAF22847.1|AF210152_4 bile
acid 7a-dehydratase from Clostridium sp. (168 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0310c"
/db_xref="EnsemblGenomes-Tr:CCP43040"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/TrEMBL:O07237"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43040.1"
/translation="MCCNGVVTPGDPADIAAIKQLKYRYLRALDTKHWDDFTDTLAED
VTGDYGSSVGTELHFTNRADLVDYLRQALGPGVITEHRVTHPEITVTGDTATGIWYLQ
DRVIVAEFNFMLIGAAFYHDQYRRTTDGWRISATGYDRTYEATMSLAGLNFNIRPGRA
LAD"
gene 379172..380401
/locus_tag="Rv0311"
CDS 379172..380401
/codon_start=1
/transl_table=11
/locus_tag="Rv0311"
/product="Unknown protein"
/note="Rv0311, (MTCY63.16), len: 409 aa. Unknown protein.
Contains PS00881 Protein splicing signature."
/db_xref="EnsemblGenomes-Gn:Rv0311"
/db_xref="EnsemblGenomes-Tr:CCP43041"
/db_xref="GOA:O07238"
/db_xref="UniProtKB/TrEMBL:O07238"
/inference="protein motif:PROSITE:PS00881"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43041.1"
/translation="MSQSRYAGLSRSELAVLLPELLLIGQLIDRSGMAWCIQAFGRQE
MLQIAIEEWAGASPIYTKRMQKALNFEGDDVPTIFKGLQLDIGAPPQFMDFRFTLHDR
WHGEFHLDHCGALLDVEPMGDDYVVGMCHTIEDPTFDATAIATNPRAQVRPIHRPPRK
PADRHPHCAWTVIIDESYPEAEGIPALDAVRETKAATWELDNVDASDDGLVDYSGPLV
SDLDFGAFSHSALVRMADEVCLQMHLLNLSFAIAVRKRAKADAQLAISVNTRQLIGVA
GLGAERIHRAMALPGGIEGALGVLELHPLLNPAGYVLAETSPDRLVVHNSPAHADGAW
ISLCTPASVQPLQAIATAVDPHLKVRISGTDTDWTAELIEADAPASELPEVLVAKVSR
GSVFQFEPRRSLPLTVK"
gene 380556..382418
/locus_tag="Rv0312"
CDS 380556..382418
/codon_start=1
/transl_table=11
/locus_tag="Rv0312"
/product="Conserved hypothetical proline and threonine
rich protein"
/note="Rv0312, (MTCY63.17), len: 620 aa. Conserved
hypothetical protein with highly Pro-, Thr-rich
C-terminus. Similar to Pro-,Thr-rich region in
Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculosis
(592 aa), FASTA scores: opt: 1075, E(): 0, (38.9% identity
in 627 aa overlap). Also some similarity with Rv0350|dnaK
from Mycobacterium tuberculosis. Possibly membrane
protein; has hydrophobic stetch in its middle part."
/db_xref="EnsemblGenomes-Gn:Rv0312"
/db_xref="EnsemblGenomes-Tr:CCP43042"
/db_xref="GOA:O07239"
/db_xref="InterPro:IPR004753"
/db_xref="InterPro:IPR013126"
/db_xref="UniProtKB/TrEMBL:O07239"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43042.1"
/translation="MYDPLGLSIGTTNLVAAGNGGPPVTRRAVLTLYPHCAPKIGVPS
QNPNLIEPGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALDAMVLTAGADASSSE
IAIAVPAHWKPGAVHALRNGLRTHVGFVRSGMAPRLVSDAIAALTAVNSELGLPHGSV
VGLLDFGGSATYVTLVETKSDSRTSDFQPVSATARYQDFSGSQIDQALLLRVIDQFGY
GDDVDPASTAAVGQLGQLREQCRAAKERLSTDVATELFAELAGCSSSIEMTREQLEDL
IQDPLTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVLTASQ
PGCAAAMGALLLANRGGERDSRTRTSIGLATAAAAGTSVIELPAGDVMVIDHEALTDR
ELAWSQTDFPSEAPARFEGDSYNEGGPCWSMRLNAVEPPKGPAWRRIRVSQLLIGVSA
VVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTPPPPPSTVAP
LPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTTTTTTAPPSTTTTTEPPVT
TTSTIPTIPTTTTTVKMTTEWLHVPFLPVPIPVPIPQNPGAGEPQNPFGSLGSG"
gene 382490..382876
/locus_tag="Rv0313"
CDS 382490..382876
/codon_start=1
/transl_table=11
/locus_tag="Rv0313"
/product="Conserved protein"
/note="Rv0313, (MTCY63.18), len: 128 aa. Conserved
protein,equivalent only to CAC32049.1|AL583926 conserved
hypothetical protein from Mycobacterium leprae (130 aa). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0313"
/db_xref="EnsemblGenomes-Tr:CCP43043"
/db_xref="UniProtKB/Swiss-Prot:P9WL03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43043.1"
/translation="MGDYGPFGFDPDEFDRVIREGSEGLRDAFERIGRFLSSSGAGTG
WSAIFEDLSRRSRPAPETAGEAGDGVWAIYTVDADGGARVEQVYATELDALRANKDNT
DPKRKVRFLPYGIAVSVLDDPVDEAQ"
gene complement(382879..383541)
/locus_tag="Rv0314c"
CDS complement(382879..383541)
/codon_start=1
/transl_table=11
/locus_tag="Rv0314c"
/product="Possible conserved membrane protein"
/note="Rv0314c, (MTCY63.19c), len: 220 aa. Possible
conserved membrane protein, with hydrophobic stretch from
residues ~75-100. Similar in C-terminal part to
Mycobacterium tuberculosis proteins Rv0679c and Rv0680c."
/db_xref="EnsemblGenomes-Gn:Rv0314c"
/db_xref="EnsemblGenomes-Tr:CCP43044"
/db_xref="GOA:O07241"
/db_xref="InterPro:IPR021417"
/db_xref="UniProtKB/TrEMBL:O07241"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43044.1"
/translation="MIVVWEHLCMNPEDDPEARIRELERPLADVARASELGGSQSGGY
TYPPGPPPPPYSYGGPFGGPSPRSSSGNRAWWILAAVVVVGVLVLVGGIAAFSAQRLS
QGNFVVLSPTPSVSRAVPTPTAQPATTLPPAGASLSVSGVNVNRTIACNDSIVSVSGM
SNTVVITGHCTSLTVSGMRNSVTVDSVDTIEAAGFNNEVTYHSGSPKISNAGGSNSVQ
QG"
gene 383602..384486
/locus_tag="Rv0315"
CDS 383602..384486
/codon_start=1
/transl_table=11
/locus_tag="Rv0315"
/product="Possible beta-1,3-glucanase precursor"
/note="Rv0315, (MTCY63.20), len: 294 aa. Possible
beta-1,3-glucanase precursor (has hydrophobic stretch in
its N-terminal part), similar to others e.g.
Q51333|AAC44371.1 beta-1,3-glucanase II a from Oerskovia
xanthineolytica (306 aa), FASTA scores: opt: 76, E():
3e-14, (34.1% identity in 302 aa overlap); and
AAC38290.1|AF052745 beta-1,3-glucanase II from Oerskovia
xanthineolytica (435 aa). Contains glycosyl hydrolases
family 16 active site signature (PS01034)."
/db_xref="EnsemblGenomes-Gn:Rv0315"
/db_xref="EnsemblGenomes-Tr:CCP43045"
/db_xref="GOA:O07242"
/db_xref="InterPro:IPR000757"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR013320"
/db_xref="PDB:4WZF"
/db_xref="UniProtKB/TrEMBL:O07242"
/inference="protein motif:PROSITE:PS01034"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43045.1"
/translation="MLMPEMDRRRMMMMAGFGALAAALPAPTAWADPSRPAAPAGPTP
APAAPAAATGGLLFHDEFDGPAGSVPDPSKWQVSNHRTPIKNPVGFDRPQFFGQYRDS
RQNVFLDGNSNLVLRATREGNRYFGGLVHGLWRGGIGTTWEARIKFNCLAPGMWPAWW
LSNDDPGRSGEIDLIEWYGNGTWPSGTTVHANPDGTAFETCPIGVDGGWHNWRVTWNP
SGMYFWLDYADGIEPYFSVPATGIEDLNEPIREWPFNDPGYKVFPVLNLAVGGSGGGD
PATGSYPQEMLVDWVRVF"
gene 384535..385149
/locus_tag="Rv0316"
CDS 384535..385149
/codon_start=1
/transl_table=11
/locus_tag="Rv0316"
/product="Possible muconolactone isomerase"
/note="Rv0316, (MTCY63.21), len: 204 aa. Possible
muconolactone isomerase, showing weak similarity with some
muconolactone isomerases e.g. O33947|CTC1_ACILW
muconolactone delta-isomerase 1 (MIASE 1)(96 aa), FASTA
scores: opt: 179, E(): 3.9e-05, (32.6% identity in 92 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0316"
/db_xref="EnsemblGenomes-Tr:CCP43046"
/db_xref="GOA:O07243"
/db_xref="InterPro:IPR011008"
/db_xref="InterPro:IPR026029"
/db_xref="UniProtKB/TrEMBL:O07243"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43046.1"
/translation="MEFLVTMTTRVPDSMPADAVERVRAREAARSRELAAQGKLLRLW
RPPLRPGEWRTLGLFAADDNGELEQLLASMPPRSWRTDDVTPLGAHPNDPVGQGITIA
PGKGPEFLIATTIMVPPGTPAQVVDDTVAREARRAPELAGRGHLVRLWALPDGPDGQR
TLGLWRARDPGELMAILESLPLAGWMTIETTPLSPHPDDPIRMP"
gene complement(385173..385943)
/gene="glpQ2"
/locus_tag="Rv0317c"
CDS complement(385173..385943)
/codon_start=1
/transl_table=11
/gene="glpQ2"
/locus_tag="Rv0317c"
/product="Possible glycerophosphoryl diester
phosphodiesterase GlpQ2 (glycerophosphodiester
phosphodiesterase)"
/note="Rv0317c, (MTCY63.22c), len: 256 aa (start
uncertain,chosen by homology). Possible glpQ2,
glycerophosphoryl diester phosphodiesterase, similar to
others e.g. E75317|6459876|AAF11631.1|AE002044_4
glycerophosphoryl diester phosphodiesterase from
Deinococcus radiodurans (285 aa); P10908|UGPQ_ECOLI from
Escherichia coli (247 aa),FASTA scores: opt: 220, E():
5.2e-07, (28.0% identity in 250 aa overlap). Also similar
to MTCY01A6.27 from Mycobacterium tuberculosis FASTA
score: (27.5% identity in 247 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0317c"
/db_xref="EnsemblGenomes-Tr:CCP43047"
/db_xref="GOA:O07244"
/db_xref="InterPro:IPR017946"
/db_xref="InterPro:IPR030395"
/db_xref="UniProtKB/TrEMBL:O07244"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43047.1"
/translation="MEFLRHGGRIAMAHRGFTSFRLPMNSMGAFQEAAKLGFRYIETD
VRATRDGVAVILHDRRLAPGVGLSGAVDRLDWRDVRKAQLGAGQSIPTLEDLLTALPD
MRVNIDIKAASAIEPTVNVIERCNAHNRVLIGSFSERRRRRALRLLTKRVASSAGTGA
LLAWLTARPLGSRAYAWRMMRDIDCVQLPSRLGGVPVITPARVRGFHAAGRQVHAWTV
DEPDVMHTLLDMDVDGIITDRADLLRDVLIARGEWDGA"
gene complement(386204..386274)
/gene="glyU"
tRNA complement(386204..386274)
/gene="glyU"
/product="tRNA-Gly"
/anticodon=(pos:complement(386240..386242),aa:Gly,seq:ccc)
/note="codon recognized: GGG; glyU, tRNA-Gly, anticodon
ccc, length = 71"
gene complement(386305..387099)
/locus_tag="Rv0318c"
CDS complement(386305..387099)
/codon_start=1
/transl_table=11
/locus_tag="Rv0318c"
/product="Probable conserved integral membrane protein"
/note="Rv0318c, (MTCY63.23c), len: 264 aa. Probable
conserved integral membrane protein, with some similarity
to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores:
opt: 157, E (): 0.0032, (28.3% identity in 198 aa
overlap). Also similar to O26573 conserved protein from
Methanobacterium thermoauto (259 aa), FASTA scores: opt:
173, E(): 5.2e-05, (32.7% identity in 214 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0318c"
/db_xref="EnsemblGenomes-Tr:CCP43048"
/db_xref="GOA:Q6MX47"
/db_xref="InterPro:IPR003689"
/db_xref="UniProtKB/TrEMBL:Q6MX47"
/protein_id="CCP43048.1"
/translation="MSLAVTMFKRARAEIFDRNREVGISNVTTAASLVTFPVLAGILG
GVVPSVRTPSAAMVSGVQHFAAGIVMAAVAGEVLPDLRSRGPLWLIVVGFSAGVAVLV
ALRRFDGHGEHQDGDDVGELPVGFLTVVAVDLFIDGLLVATGATVSSRTAIIITIALT
VEVLFLGLAVALRLAGSGMPRIRAAATTSALSLVIAVGGVSGAVALGRAGNTVLTLVL
AFAAGALLWLVVEELLVEAHETPERPWMAVMFFAGFLILYGLGVME"
gene 387148..387816
/gene="pcp"
/locus_tag="Rv0319"
CDS 387148..387816
/codon_start=1
/transl_table=11
/gene="pcp"
/locus_tag="Rv0319"
/product="Probable pyrrolidone-carboxylate peptidase Pcp
(5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I)
(pyrase)"
/note="Rv0319, (MTCY63.24), len: 222 aa. Probable
pcp,pyrrolidone-carboxylate peptidase, highly similar to
others e.g. PCP_PSEFL|P42673 pyrrolidone-carboxylate
peptidase from Pseudomonas fluorescens (213 aa), FASTA
scores: opt: 478, E(): 7.5e-25, (40.2% identity in 219 aa
overlap). Belongs to peptidase family C15 (thiol
protease)."
/db_xref="EnsemblGenomes-Gn:Rv0319"
/db_xref="EnsemblGenomes-Tr:CCP43049"
/db_xref="GOA:P9WIJ5"
/db_xref="InterPro:IPR000816"
/db_xref="InterPro:IPR016125"
/db_xref="InterPro:IPR029762"
/db_xref="InterPro:IPR033693"
/db_xref="InterPro:IPR033694"
/db_xref="InterPro:IPR036440"
/db_xref="UniProtKB/Swiss-Prot:P9WIJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43049.1"
/translation="MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPN
TFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVL
VGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQK
GLPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPS
RLQI"
gene 387888..388550
/locus_tag="Rv0320"
CDS 387888..388550
/codon_start=1
/transl_table=11
/locus_tag="Rv0320"
/product="Possible conserved exported protein"
/note="Rv0320, (MTCY63.25), len: 220 aa. Possible
conserved exported protein, similar to some hypothetical
proteins and to the middle part of a peptidase:
NP_066789.1|10657900|AAG21739.1|AF116907 putative
peptidase from Rhodococcus equi (546 aa). Also similar to
Rv1728c|MTCY04C12.13c from Mycobacterium tuberculosis (256
aa), FASTA scores: opt: 497, E(): 1.2e-26, (41.8% identity
in 225 aa overlap). Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0320"
/db_xref="EnsemblGenomes-Tr:CCP43050"
/db_xref="UniProtKB/TrEMBL:O07246"
/protein_id="CCP43050.1"
/translation="MGRHELARDRRKSSAVLAAVLAPAAVFFATGGDVSTLAARADAN
PVLGDDAPCCVQIVPVAPLAFSSQISGGEIGTGLAASQFASASRWRIVSRYLPVGVAP
EQGLQVKTVLTARSISAAFPEIREIGGVRPDALRWHPNGLALDVMVPNPGTAEGIALG
NEIVAFVLKNATRFGMQDVIWRGAYYTPNGARTTGAGHYDHIHITTVGGGYPTGEELY
IR"
gene 388582..389154
/gene="dcd"
/gene_synonym="dus"
/gene_synonym="paxA"
/locus_tag="Rv0321"
CDS 388582..389154
/codon_start=1
/transl_table=11
/gene="dcd"
/gene_synonym="dus"
/gene_synonym="paxA"
/locus_tag="Rv0321"
/product="Probable deoxycytidine triphosphate deaminase
Dcd (dCTP deaminase)"
/note="Rv0321, (MTCY63.26), len: 190 aa. Probable dcd
(alternate gene names: dus or paxA), deoxycytidine
triphosphate deaminase, equivalent to CAC32024.1|AL583925
probable deoxycytidine triphosphate deaminase from
Mycobacterium leprae (190 aa). Also highly similar to
others e.g. Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46
deoxycytidine triphosphate deaminase from Streptomyces
coelicolor (191 aa); DCD_ECOLI|P28248|DUS|PAXA|B2065
deoxycytidine triphosphate deaminase from Escherichia coli
strain K12 (193 aa), FASTA scores: opt: 408, E():
2.7e-21,(43.1% identity in 188 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the dCTP deaminase family. The transcription of this CDS
seems to be activated specifically in host granulomas (see
citation below)."
/db_xref="EnsemblGenomes-Gn:Rv0321"
/db_xref="EnsemblGenomes-Tr:CCP43051"
/db_xref="GOA:P9WP17"
/db_xref="InterPro:IPR011962"
/db_xref="InterPro:IPR029054"
/db_xref="InterPro:IPR033704"
/db_xref="InterPro:IPR036157"
/db_xref="PDB:2QLP"
/db_xref="PDB:2QXX"
/db_xref="PDB:4A6A"
/db_xref="UniProtKB/Swiss-Prot:P9WP17"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43051.1"
/translation="MLLSDRDLRAEISSGRLGIDPFDDTLVQPSSIDVRLDCLFRVFN
NTRYTHIDPAKQQDELTSLVQPVDGEPFVLHPGEFVLGSTLELFTLPDNLAGRLEGKS
SLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCMLRLTSPSEH
PYGSSRAGSKYQGQRGPTPSRSYQNFIRST"
gene 389260..390591
/gene="udgA"
/gene_synonym="rkpK"
/locus_tag="Rv0322"
CDS 389260..390591
/codon_start=1
/transl_table=11
/gene="udgA"
/gene_synonym="rkpK"
/locus_tag="Rv0322"
/product="Probable UDP-glucose 6-dehydrogenase UdgA
(UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH)"
/note="Rv0322, (MTCY63.27), len: 443 aa. Probable udg
(alternate gene name: rkpK), UDP-glucose 6-dehydrogenase
,highly similar to others e.g. CAC44517.1|AL596138
putative UDP-glucose 6-dehydrogenase from Streptomyces
coelicolor (447 aa); Q56812 UDP-glucose dehydrogenase from
Xanthomonas campestris (445 aa), FASTA scores: opt: 713,
E(): 0, (41.9% identity in 351 aa overlap); etc. Also
similar to several GDP-mannose 6-dehydrogenase. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the UDP-glucose/GDP-mannose dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0322"
/db_xref="EnsemblGenomes-Tr:CCP43052"
/db_xref="GOA:O07248"
/db_xref="InterPro:IPR001732"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR014026"
/db_xref="InterPro:IPR014027"
/db_xref="InterPro:IPR017476"
/db_xref="InterPro:IPR028357"
/db_xref="InterPro:IPR036220"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O07248"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43052.1"
/translation="MRCSVFGTGYLGATHAVGMAQLGHEVVGVDIDPGKVAKLAGGDI
PFYEPGLRKLLTDNLAAGRLRFTTDYDMAADFADVHFLGVGTPQKIGEYGADLRHVHA
VIDALVPRLVRASILVGKSTVPVGTAAELGHRAGALAPRGVDVEIAWNPEFLREGFAV
HDTLNPDRIVLGVQDDSTRAEVAVRELYAPLLAAGVPFLVTDLQTAELVKVSANAFLA
TKISFINAISEVCEAAGADVSQLADALGYDPRIGRQCLNAGLGFGGGCLPKDIRAFMA
RAGELGADQALTFLREVDSINMRRRTKMVELATTACGGSLLGANIAVLGAAFKPESDD
VRDSPALNVAGQLQLNGATVHVYDPKALDNAHRLFPTLNYAVSVAEACERADAVLVLT
EWREFIDLEPADLANRVRARVIVDGRNCLDVTRWRRAGWRVFRLGVPRLGH"
gene complement(390580..391251)
/locus_tag="Rv0323c"
CDS complement(390580..391251)
/codon_start=1
/transl_table=11
/locus_tag="Rv0323c"
/product="Conserved hypothetical protein"
/note="Rv0323c, (MTCY63.28c), len: 223 aa. Conserved
hypothetical protein, similar to others e.g.
YPJG_BACSU|P42981 hypothetical 24.8 kDa protein from
Bacillus subtilis (224 aa), FASTA scores: opt: 182, E():
1.3e-05, (27.5% identity in 211 aa overlap). Also some
similarity to MLU15183_8 from Mycobacterium tuberculosis
FASTA score: (32.0% identity in 147 aa overlap).
Alternative nucleotide at position 390828 (T->C; S142G)
has been observed. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0323c"
/db_xref="EnsemblGenomes-Tr:CCP43053"
/db_xref="InterPro:IPR003737"
/db_xref="InterPro:IPR024078"
/db_xref="UniProtKB/TrEMBL:L0T643"
/protein_id="CCP43053.1"
/translation="MNSCNRLPCAHEVLAVFAHPDDESFGLGAVLGDFTAQGTRLRGL
CFTHGEASTLGRTDRNLGEVRREELAAAAQVLGVDHVQLLAYPDNGLAQIPLNELTQR
VVDALAGADLLLVFDDNGVTGHPDHRRATEAALAAASTPSIPVLAWALPQPIADRLNA
EFSASFGGRGHGHLDIMIEVDRSRQLAAIGCHFTQSADNPVLWRRLELLGDREYLRWL
RRSVP"
gene 391352..392032
/locus_tag="Rv0324"
CDS 391352..392032
/codon_start=1
/transl_table=11
/locus_tag="Rv0324"
/product="Possible transcriptional regulatory protein
(possibly ArsR-family)"
/note="Rv0324, (MTCY63.29), len: 226 aa. Possible
transcriptional regulator, arsR family, with its
N-terminus similar to the N-terminus of other DNA-binding
proteins e.g. P30346|MERR_STRLI probable mercury
resistance operon from Streptomyces lividans (125 aa),
FASTA scores: opt: 154, E(): 0.002, (32.2% identity in 90
aa overlap), and its C-terminal part similar to
hypothetical bacterial proteins e.g. P54510|YQHL_BACSU
hypothetical 14.6 kDa protein from Bacillus subtilis (126
aa), FASTA scores: opt: 159, E(): 0.00097, (35.5% identity
in 76 aa overlap). Most similar to AJ005575|SPE005575_2
ORF1 required for antibiotic production from Streptomyces
peucetius (226 aa), FASTA scores: opt: 816, E(): 0, (60.7%
identity in 211 aa overlap). Also similar in C-terminus to
MTCY164.26 molybdopterin biosynthesis moeb protein from
Mycobacterium tuberculosis FASTA score: (36.8% identity in
114 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0324"
/db_xref="EnsemblGenomes-Tr:CCP43054"
/db_xref="GOA:O08446"
/db_xref="InterPro:IPR001307"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR036873"
/db_xref="UniProtKB/TrEMBL:O08446"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43054.1"
/translation="MAGQSDRKAALLDQVARVGKALANGRRLQILDLLAQGERAVEAI
ATATGMNLTTASANLQALKSGGLVEARREGTRQYYRIAGEDVARLFALVQVVADEHLA
DVAVAAADVLGSPEDAITRAELLRRREAGEVTLVDVRPHEEYQAGHIPGAINIPIAEL
ADRLAELTGDRDIVAYCRGAYCVMAPDAVRIARDAGREVKRLDDGMLEWRLAGLPVDE
GAPVGHGD"
gene 392039..392263
/locus_tag="Rv0325"
CDS 392039..392263
/codon_start=1
/transl_table=11
/locus_tag="Rv0325"
/product="Hypothetical protein"
/note="Rv0325, (MTCY63.30), len: 74 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0325"
/db_xref="EnsemblGenomes-Tr:CCP43055"
/db_xref="GOA:O07250"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O07250"
/protein_id="CCP43055.1"
/translation="MGPKGSLRLVKRQPELLVAQHEHWQDTYRAHPVLYGTRPSEPGV
YAAEVFNADGVQRVLELAAGHGRDTLYFAG"
gene 392273..392728
/locus_tag="Rv0326"
CDS 392273..392728
/codon_start=1
/transl_table=11
/locus_tag="Rv0326"
/product="Hypothetical protein"
/note="Rv0326, (MTCY63.31), len: 151 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0326"
/db_xref="EnsemblGenomes-Tr:CCP43056"
/db_xref="GOA:O07251"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:O07251"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43056.1"
/translation="MVATDFSDVAVAQLRRSAQARGVSARVQPIVHDLRQPLPVKTGS
IDGAFAHMALCMALSTSEIHAVVAEVGRVLRPGGKFIYTVRHTGDAHYGAGQAHGDDI
FECAGFAVHFFRRELVARLATGWVLEEVHDFEEGELPRRLWRVTVTKPA"
gene complement(392696..394045)
/gene="cyp135A1"
/locus_tag="Rv0327c"
CDS complement(392696..394045)
/codon_start=1
/transl_table=11
/gene="cyp135A1"
/locus_tag="Rv0327c"
/product="Possible cytochrome P450 135A1 Cyp135A1"
/note="Rv0327c, (MT0342, MTCY63.32c), len: 449 aa.
Possible cyp135A1, cytochrome P450, similar to cytochrome
P-450 monoxygenases and other cytochrome P-450 related
enzymes e.g. FQ12609 putative P450 monooxygenase (506 aa),
FASTA scores: opt: 276, E() : 1.7e-11, (27.9% identity in
433 aa overlap). Also similar to other Mycobacterium
tuberculosis proteins e.g. MTV039.06|Rv0568 putative
cytochrome P450 (472 aa); MTCI5.10 cytochrome p450 FASTA
score: (30.4% identity in 434 aa overlap). Contains
cytochrome P450 cysteine heme-iron ligand signature
(PS00086). Belongs to the cytochrome P450 family.
Alternative start possible at 33706 but no RBS. This
region is a possible MT-complex-specific genomic island
(See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0327c"
/db_xref="EnsemblGenomes-Tr:CCP43057"
/db_xref="GOA:P9WPN1"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002401"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPN1"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP43057.1"
/translation="MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFS
LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHAR
MRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFG
VTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIA
SRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLW
ELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPA
GTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTE
GAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP"
gene 394111..394713
/locus_tag="Rv0328"
CDS 394111..394713
/codon_start=1
/transl_table=11
/locus_tag="Rv0328"
/product="Possible transcriptional regulatory protein
(possibly TetR/AcrR-family)"
/note="Rv0328, (MTCY63.33), len: 200 aa. Possible
transcription regulator, TetR/acrR family, similar in part
to various hypothetical transcriptional regulators e.g.
T36696|4726006|CAB41735.1|AL049731 probable regulatory
protein from Streptomyces coelicolor (197 aa). Also some
similarity with YX44_MYCTU|Q10829 hypothetical
transcriptional regulator from Mycobacterium tuberculosis
(195 aa), FASTA scores: opt: 154, E(): 0.00061, (26.7%
identity in 202 aa overlap). Contains probable helix-turn
helix motif from aa 27-48 (Score 1408, +3.98 SD). Seems to
belong to the TetR/AcrR family of transcriptional
regulators. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0328"
/db_xref="EnsemblGenomes-Tr:CCP43058"
/db_xref="GOA:O07252"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR039538"
/db_xref="UniProtKB/TrEMBL:O07252"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43058.1"
/translation="MQQQRTNRDKLLDGALACLRERGYGNTSSRDIARAAGVNIASIN
YHFGSKDALLDDALGRCFSTWNQRVQEAFDHSRAAGPAGQILAVLEATVDSFEQIRPA
VYACVESYAPALRSEALRERLAAGYADVRQHSVDLAGAALAGTDIAPPENLSTIVSVL
MAVIDGLMIQWIADPSATPRSTEVIRALASIGAVVTSQLR"
gene complement(394694..395320)
/locus_tag="Rv0329c"
CDS complement(394694..395320)
/codon_start=1
/transl_table=11
/locus_tag="Rv0329c"
/product="Conserved hypothetical protein"
/note="Rv0329c, (MTCY63.34c), len: 208 aa. Conserved
hypothetical protein, showing some similarity with others
hypothetical proteins and methyltransferases e.g.
MitM|AF127374_14 methyltransferase from Streptomyces
lavendulae (283 aa), FASTA scores: opt: 242, E():
1.8e-08,(37.2% identity in 145 aa overlap); Q48938 from
Methanosarcina barkeri (262 aa), FASTA scores: opt:
194,E(): 3.6e-06, (31.1% identity in 119 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0329c"
/db_xref="EnsemblGenomes-Tr:CCP43059"
/db_xref="GOA:O07253"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O07253"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43059.1"
/translation="MRLTHPARRYLSSQAARPTGAFGRLLGRIWRAETADVNRIAVEL
LAPGPGERVCEIGFGPGRTLGLLAAAGAQVSGVEVSTTMIAIAAHHNAKAIAAGLISL
YHGDGVTLPVADHSLDKVLGVHNFYFWPDPRASLCDIARALRPGGRLVLTSISDDQPL
AARFDPAIYRVPPTLDTAAWLGAAGFIDVGIKRSADHPATVWFTATAT"
gene complement(395347..396087)
/locus_tag="Rv0330c"
CDS complement(395347..396087)
/codon_start=1
/transl_table=11
/locus_tag="Rv0330c"
/product="Hypothetical protein"
/note="Rv0330c, (MTCY63.35c), len: 246 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0330c"
/db_xref="EnsemblGenomes-Tr:CCP43060"
/db_xref="GOA:O07254"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:O07254"
/protein_id="CCP43060.1"
/translation="MARSIPADRFSAIVAASARVFIAHGYQRTQVQDVADALALAKGT
LYGYAQGKAALFAAAVRYGDAQEALPLASELPVAAPVAGEIAAVVSARLAGEVTDMRL
THALRATLPPGATTGDARAELAGIVTDLYSRLARHRIALKLVDRCAPELPDLAEVWFG
TGRNAQVDAVQAYLVHRERAGLLILPGPAPMVARTIVELCALWAVHLHFDPSPEPWSI
VQPGVIDDDAIAATLAEFVVRATTASSD"
gene 396201..397367
/locus_tag="Rv0331"
CDS 396201..397367
/codon_start=1
/transl_table=11
/locus_tag="Rv0331"
/product="Possible dehydrogenase/reductase"
/note="Rv0331, (MTCY63.36), len: 388 aa. Possible
dehydrogenase/reductase, similar to various
dehydrogenases/reductases e.g.
NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein
reductase from Mesorhizobium loti (377 aa); NP_147681.1
predicted NAD(FAD)-dependent dehydrogenase from Aeropyrum
pernix (381 aa); DHSU_CHRVI|Q06530 sulfide dehydrogenase
(431 aa), FASTA scores: opt: 347, E(): 6.8e-15, (25.6%
identity in 348 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0331"
/db_xref="EnsemblGenomes-Tr:CCP43061"
/db_xref="GOA:O07255"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O07255"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43061.1"
/translation="MSKTVLILGAGVGGLTTADTLRQLLPPEDRIILVDRSFDGTLGL
SLLWVLRGWRRPDDVRVRPTAASLPGVEMVTATVAHIDIAAQVVHTDNSVIGYDALVI
ALGAALNTDAVPGLSDALDADVAGQFYTLDGAAELRAKVEALEHGRIAVAIAGVPFKC
PAAPFEAAFLIAAQLGDRYATGTVQIDTFTPDPLPMPVAGPEVGEALVSMLKDHGVGF
HPRKALARVDEAARTMHFGDGTSEPFDLLAVVPPHVPSAAARSAGLSESGWIPVDPRT
LSTSADNVWAIGDATVLTLPNGKPLPKAAVFAEAQAAVVAHGVARHLGYDVAERHFTG
TGACYVETGDHQAAKGDGDFFAPSAPSVTLYPPSREFHEEKVAQELAWLTRWKT"
gene 397442..398227
/locus_tag="Rv0332"
CDS 397442..398227
/codon_start=1
/transl_table=11
/locus_tag="Rv0332"
/product="Conserved protein"
/note="Rv0332, (MTCY63.37), len: 261 aa. Conserved
protein,similar to several conserved hypothetical proteins
from Streptomyces coelicolor e.g.
SC6A9.18c|AL031035|SC6A9_18|T35449 hypothetical protein
(266 aa), FASTA scores: opt: 508, E(): 5.7e-27, (36.7%
identity in 251 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0332"
/db_xref="EnsemblGenomes-Tr:CCP43062"
/db_xref="GOA:O07256"
/db_xref="InterPro:IPR010872"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR024344"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/TrEMBL:O07256"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43062.1"
/translation="MRKPASSLAKVDYSSAYLEQTHAFGELIRNVDQSTPVPTCPGWS
LGQLFRHVGRGDRWAAQIVRDRLDHFLDPRSVEGGKPPPDPDDAISWLYGGARLLVDA
VEQTGVETPVWTFLGPRPAGWWVRRRLHEVAVHRADVAITVGGEFTLEPNVAADGISE
FLERIAVQAGSGGTPLPLEDDDTLHLHATDPGLLEAGEWTVRRDERGVTWSHRHGKGA
VALRGGATELLLAMVRRLSVADTGIELLGDAGVWQKWLDRTPL"
gene 398254..398628
/locus_tag="Rv0333"
CDS 398254..398628
/codon_start=1
/transl_table=11
/locus_tag="Rv0333"
/product="Unknown protein"
/note="Rv0333, (MTCY63.38), len: 124 aa. Unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0333"
/db_xref="EnsemblGenomes-Tr:CCP43063"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/TrEMBL:O33273"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43063.1"
/translation="MTTSEIATVLAWHDALNAADIETLVALSTDDIDIGDAHGAVQGH
DALRGWASSLTTTAELGRMYVHHGVVVVEQKITSGEDPGIARTGAAAFRVVQDHVASV
FRHEDLASALAATELTEDDLVD"
gene 398658..399524
/gene="rmlA"
/gene_synonym="rfbA"
/locus_tag="Rv0334"
CDS 398658..399524
/codon_start=1
/transl_table=11
/gene="rmlA"
/gene_synonym="rfbA"
/locus_tag="Rv0334"
/product="Alpha-D-glucose-1-phosphate
thymidylyltransferase RmlA (dTDP-glucose synthase)
(dTDP-glucose pyrophosphorylase)"
/note="Rv0334, (MTCY279.01), len: 288 aa. RmlA (alternate
gene name: rfbA), alpha-D-glucose-1-phosphate
thymidylyl-transferase (see citations below), equivalent
to CAC32020.1|AL583925 glucose-1-phosphate
thymidyltransferase from Mycobacterium leprae (288 aa).
Also highly similar to others e.g. AAG29804.1|AF235050
glucose-1-phosphate thymidylyltransferase from
Streptomyces rishiriensis (296 aa); RBA1_ECOLI|P37744
glucose-1-phosphate thymidylyltransferase from Escherichia
coli strain K12 (293 aa), FASTA scores: opt: 1199, E(): 0,
(62.0% identity in 284 aa overlap). Belongs to the
glucose-1-phosphate thymidylyltransferase family."
/db_xref="EnsemblGenomes-Gn:Rv0334"
/db_xref="EnsemblGenomes-Tr:CCP43064"
/db_xref="GOA:P9WH13"
/db_xref="InterPro:IPR005835"
/db_xref="InterPro:IPR005907"
/db_xref="InterPro:IPR029044"
/db_xref="PDB:6B5E"
/db_xref="PDB:6B5K"
/db_xref="UniProtKB/Swiss-Prot:P9WH13"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43064.1"
/translation="MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMA
GIRDIQLITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGADSV
ALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAEGMALSLEEKP
VTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRLAVEVLARGT
AWLDTGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGWIDDEQLVQRARALVKSG
YGNYLLELLERN"
gene complement(399535..400050)
/gene="PE6"
/locus_tag="Rv0335c"
CDS complement(399535..400050)
/codon_start=1
/transl_table=11
/gene="PE6"
/locus_tag="Rv0335c"
/product="PE family protein PE6"
/note="Rv0335c, (MTCY279.02c), len: 171 aa. PE6, Member of
the Mycobacterium tuberculosis PE family (see Brennan &
Delogu 2002); contains short region of similarity to part
of the unique N-terminus of the Mycobacterium tuberculosis
PGRS family of Glycine-rich proteins e.g.
Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd
protein (603 aa), FASTA scores: opt: 219, E(): 1.1e-08,
(51.5% identity in 66 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0335c"
/db_xref="EnsemblGenomes-Tr:CCP43065"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N648"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43065.1"
/translation="MRSMGFLHRACRAPSSLPAPLMARPGRSVLARPAATPPGPLCAT
TRPRPPQGNQPPASRISNFPPKRHKTRVLAAAEDEVSAAVAALISAHGRRHHSLNNQA
AAFHGQFAQNLNVGAGSCASAETTADAPTQALLGPADRQRRQRRAVRQWLVRWAAHPG
RATRGFHNHRQ"
gene 400192..401703
/locus_tag="Rv0336"
CDS 400192..401703
/codon_start=1
/transl_table=11
/locus_tag="Rv0336"
/product="Conserved 13E12 repeat family protein"
/note="Rv0336, (MTCY279.03), len: 503 aa. Part of
Mycobacterium tuberculosis 13E12 repeat family; almost
identical to Rv0515|MTCY20G10.05 hypothetical protein from
Mycobacterium tuberculosis FASTA scores: (99.8% identity
in 503 aa overlap), possibly due to a recent gene
duplication. Also similar to other Mycobacterium
tuberculosis hypothetical proteins e.g. Rv1148c, Rv1945,
etc."
/db_xref="EnsemblGenomes-Gn:Rv0336"
/db_xref="EnsemblGenomes-Tr:CCP43066"
/db_xref="GOA:O33266"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:O33266"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43066.1"
/translation="MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAA
AQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRE
RLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLA
GQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSAL
AGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEA
ATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADF
VRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQ
QLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPK
RRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDPNDDPPPF"
gene complement(401873..403162)
/gene="aspC"
/locus_tag="Rv0337c"
CDS complement(401873..403162)
/codon_start=1
/transl_table=11
/gene="aspC"
/locus_tag="Rv0337c"
/product="Probable aspartate aminotransferase AspC
(transaminase A) (ASPAT)"
/note="Rv0337c, (MTCY279.04c), len: 429 aa. Probable
aspC,aspartate aminotransferase (transaminase A),
equivalent to CAC32019.1|AL583925 probable aspartate
aminotransferase from Mycobacterium leprae (437 aa). Also
highly similar to many e.g. Q48143|U32823 aspartate
aminotransferase (404 aa), FASTA scores: opt: 1646, E():
0, (57.2% identity in 404 aa overlap). Also some
similarity to Rv3565|MTCY06G11.12 from Mycobacterium
tuberculosis FASTA score: (27.2% identity in 383 aa
overlap). Belongs to class-I of
pyridoxal-phosphate-dependent aminotransferases. Cofactor:
pyridoxal phosphate."
/db_xref="EnsemblGenomes-Gn:Rv0337c"
/db_xref="EnsemblGenomes-Tr:CCP43067"
/db_xref="GOA:P9WQ91"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WQ91"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43067.1"
/translation="MDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGP
VHQHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSAR
RAVVTRYELVPGFPRFDVDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTAS
TSLAGGTPVHYLCDETQGWQPDIADLESKITERTKALVVINPNNPTGAVYSCEILTQM
VDLARKHQLLLLADEIYDKILYDDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGW
LAITGPKEHASSFIEGIGLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQ
RDIAWTKLNEIPGVSCVKPAGALYAFPRLDPEVYDIDDDEQLVLDLLLSEKILVTQGT
GFNWPAPDHLRLVTLPWSRDLAAAIERLGNFLVSYRQ"
gene complement(403193..405841)
/locus_tag="Rv0338c"
CDS complement(403193..405841)
/codon_start=1
/transl_table=11
/locus_tag="Rv0338c"
/product="Probable iron-sulfur-binding reductase"
/note="Rv0338c, (MTCY279.05c), len: 882 aa. Probable
iron-sulphur-binding reductase, possibly
membrane-bound,equivalent to CAC32018.1|AL583925 probable
iron-sulphur-binding reductase from Mycobacterium leprae
(880 aa). Also highly similar to others e.g.
T36608|5019323|CAB44376.1|AL078610 probable
iron-sulfur-binding reductase from Streptomyces coelicolor
(760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity
in 772 aa overlap); BAB07521.1|AP001520
iron-sulphur-binding reductase from Bacillus halodurans
(700 aa). Contains PS00070 Aldehyde dehydrogenases
cysteine active site and two of PS00198 4Fe-4S
ferredoxins,iron-sulfur binding region signature. First of
several possible start sites chosen."
/db_xref="EnsemblGenomes-Gn:Rv0338c"
/db_xref="EnsemblGenomes-Tr:CCP43068"
/db_xref="GOA:O33268"
/db_xref="InterPro:IPR004017"
/db_xref="InterPro:IPR009051"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR017900"
/db_xref="UniProtKB/TrEMBL:O33268"
/inference="protein motif:PROSITE:PS00070"
/inference="protein motif:PROSITE:PS00198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43068.1"
/translation="MTTQTLIRLILGMSMTAVVGVFALRRVWWLYKLVMSGQPASGRT
DNLGTRIWTQISEVLGQRRLLKWSIPGLAHFFTMWGFFILLTVYIEAYGLLFEERFHI
PVIGRWDALGFLQDFFATAVFLGITTFAIIRILRNPREIGRSSRFYGSHNGGAWLVLL
MIFNVIWTYVLVRGSAVNNGTLPYGNGAFLSQLFGAILRPLGQPANEIIETTALLLHI
GVMLAFLILVLHSKHLHIFLAPINVTFKRLPDGLGPLLPLEADGKPIDFENPSEDAVF
GRGKIEDFTWKGMLDFATCTECGRCQSQCPAWNTGKPLSPKLVIMDLRDHWMAKAPYI
LGQKDASAGGEAGHQEHHHVPESGFGRVPGHGPEQATRPLVGTEEQGGVIDPDVLWSC
VTCGACVEQCPVDIEHVDHIVDMRRYQVMMESEFPSELSVLFKNLETKGNPWGQNASD
RTNWIDEVDFDVPVYGQDVDSFDGYEYLFWVGCAGAYDDKAKKTTKAVAELLAVARVK
YLVLGAGETCNGDSARRSGNEFLFQQLAQQAVETLDGLFEGVETVDRKIVVTCPHCFN
TIGKEYRQLGANYTVLHHTQLLNRLVRDKRLVPVTPVSQDITYHDPCYLGRHNKAYEA
PRELIGAAGASLTEMPRHADRSFCCGAGGARMWMEEHIGKRINHERVDEALATDATAI
ATACPFCRVMVTDGVNDRQEEAGRSGVEVLDVAQVLLGSLDHDKAQLPAKGTAAKQAQ
ERAPKAAPKAAAPVTPVEAPAEAPQAPAPAAPAAPVKGLGMAAGAKRPGAKKAAPTPA
APAAPAAPVKGLGIAAGAKRPGAKKTPPPAPGLAEPAAQPQPEAKPQPEPAAPPKPQT
DGDPAAPAAPVKGLGIARGARPPGKR"
gene complement(405950..408448)
/locus_tag="Rv0339c"
CDS complement(405950..408448)
/codon_start=1
/transl_table=11
/locus_tag="Rv0339c"
/product="Possible transcriptional regulatory protein"
/note="Rv0339c, (MTCY279.06c), len: 832 aa. Possible
transcriptional regulator, showing very weak similarity
with parts of others. Contains PS00017 ATP/GTP-binding
site motif A (P-loop); and probable helix-turn helix motif
from aa 778-799 (Score 1041, +2.73 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0339c"
/db_xref="EnsemblGenomes-Tr:CCP43069"
/db_xref="GOA:O33269"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:O33269"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP43069.1"
/translation="MQHRGCKNRGQAYDASVTDSLTEVPPAARRALLELANAPTVPVK
VLITGGIGTGKTTVLAAARDTLRRSGLTVLACPPPDGEPPETALVIDDAQLLTDTELL
RLTERVADSRLTVVAAAEAREHHRALRALTMALERDRPRISLGPLPVAEHLRDCTAGL
PFLIHAVSARAQAPAQAAKVALIERLRRLDEPTLDTLLMMSLTHELGVSDVAAALGIS
VTDARGLVDRAHASGLIESSHTAAFLQSVHDAIAQIVGNAHHHEVETSLLRSQLDISP
VSAELALRLAEHGLRDERLADILTRYAADTRDASVRCARLYRAAVHAGAKGLTVRLAD
ALARTGDCTAAATLADDLLSSPDATERAAAVRVAASVAVHDGNTGHAAELFGWLGPHP
DTMVSSAATIVFAANGDLATARATLRLKDAGPPTMAARCARNLAEGLLLTMDQPYPVA
MAKLGQAIATEQSLSQVIPDSPAALVTLAAIHAGDPVRARSVIGRAVRAGADPLFQRR
HLLLSGWIKMQEGQLPSASADVAAASAGTHLHRRDALWAAALQTAISRRTGDIGALQQ
HWYAAMEALAEYSLDLFALLPLGELWVAAARMRQVDQLQHTLDQALTLLDSLGNPALW
SNSLHWAGVHAGILANSPESVAPHGQALGAMVAHSTLAQALSDAGRTWLRVLAENVDA
DEVTAAARSLSHVGLTSDATRLAGQAALQTSDARVSGAMLQLARDLKLGNDFGEPPSG
AGDTEPASGTPPAPRQPPAGSPLSDREREVAELLLLGMPYRDIGARLFISAKTVEHHV
ARIRQRLGAGSRSEMLSMLRAMLAPESLTADERR"
gene 408634..409173
/locus_tag="Rv0340"
CDS 408634..409173
/codon_start=1
/transl_table=11
/locus_tag="Rv0340"
/product="Conserved protein"
/note="Rv0340, (MTCY279.07), len: 179 aa. Conserved
protein; MEME-mast analysis shows similarity to product of
downstream gene, Rv0341|iniB."
/db_xref="EnsemblGenomes-Gn:Rv0340"
/db_xref="EnsemblGenomes-Tr:CCP43070"
/db_xref="GOA:O33270"
/db_xref="UniProtKB/TrEMBL:O33270"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43070.1"
/translation="MANSLLDFVISLVRDPEAAARYAANPERSIAEAHLTDVTRADVN
SLIPVVSDSLSMSEPIGAAGGAHAGDRGNVWASGAATAALDAFAPHADAGVVQQHGAV
GSVLNQPTPPGPGVTPTDPRPFRAGPHETSALLTSAEIPDTTSEDGGLPTDHPAVWNH
PVVDPHTVEPDHHGYDIHG"
gene 409362..410801
/gene="iniB"
/locus_tag="Rv0341"
CDS 409362..410801
/codon_start=1
/transl_table=11
/gene="iniB"
/locus_tag="Rv0341"
/product="Isoniazid inductible gene protein IniB"
/note="Rv0341, (MTCY13E10.01), len: 479 aa.
IniB,isoniazid-inducible gene, (see citations below).
Protein very Gly-, Ala-rich, similar to cell wall proteins
e.g. P27483|GRP_ARATH glycine-rich cell wall structural
protein from A.thaliana (338 aa), FASTA scores: opt: 532,
E(): 5.2e-13, (39.3% identity in 321 aa overlap).
MEME-mast analysis shows similarity to product of upstream
gene,Rv0340."
/db_xref="EnsemblGenomes-Gn:Rv0341"
/db_xref="EnsemblGenomes-Tr:CCP43071"
/db_xref="UniProtKB/Swiss-Prot:P9WJ97"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43071.1"
/translation="MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISS
VAANVVPGLNLGAGDPMSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAG
LASGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGT
GLGAQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGA
GVGAGVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGA
ALNGAAMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAA
AGVVGGVGGATAAGVGGAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGG
TGGYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVTQPQHTPVEPPVHDKPPSHSVF
DVGHEPPVTHTPPAPIELPSYGLFGLPGF"
gene 410838..412760
/gene="iniA"
/locus_tag="Rv0342"
CDS 410838..412760
/codon_start=1
/transl_table=11
/gene="iniA"
/locus_tag="Rv0342"
/product="Isoniazid inductible gene protein IniA"
/note="Rv0342, iniA, (MTCY13E10.02), len: 640 aa.
IniA,isoniazid-inducible gene, (see citations below).
Shows slight similarity to some hypothetical bacterial
proteins e.g. P40983|YOR6_THER hypothetical protein (402
aa), FASTA scores: opt: 242, E(): 1.4e-07, (22.3% identity
in 349 aa overlap). Also some similarity to downstream ORF
Rv0343|iniC. Possible transmembrane stretch around residue
490. Alternative start site exists at 410824. Contains a
phosphopantetheine attachment site motif suggestive of an
acyl carrier protein. Note that the iniA gene is also
induced by the antibiotic ethambutol, an agent that
inhibits cell wall biosynthesis by a mechanism that is
distinct from isoniazid."
/db_xref="EnsemblGenomes-Gn:Rv0342"
/db_xref="EnsemblGenomes-Tr:CCP43072"
/db_xref="GOA:P9WJ99"
/db_xref="InterPro:IPR022812"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WJ99"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43072.1"
/translation="MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTI
AIAKLNERGDLVQRLTRARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDE
ATVVITVVSYSAQPSARLVLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEV
GAPSPLLRGGLAFIDTPGVGGLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFV
RQAHQICPVGAVVATKTDLYPRWREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLN
DKELNEESNFPAIVKFLSEQVLSRATERVRAGVLGEIRSATEQLAVSLGSELSVVNDP
NLRDRLASDLERRKREAQQAVQQTALWQQVLGDGFNDLTADVDHDLRTRFRTVTEDAE
RQIDSCDPTAHWAEIGNDVENAIATAVGDNFVWAYQRSEALADDVARSFADAGLDSVL
SAELSPHVMGTDFGRLKALGRMESKPLRRGHKMIIGMRGSYGGVVMIGMLSSVVGLGL
FNPLSVGAGLILGRMAYKEDKQNRLLRVRSEAKANVRRFVDDISFVVSKQSRDRLKMI
QRLLRDHYREIAEEITRSLTESLQATIAAAQVAETERDNRIRELQRQLGILSQVNDNL
AGLEPTLTPRASLGRA"
gene 412757..414238
/gene="iniC"
/locus_tag="Rv0343"
CDS 412757..414238
/codon_start=1
/transl_table=11
/gene="iniC"
/locus_tag="Rv0343"
/product="Isoniazid inductible gene protein IniC"
/note="Rv0343, (MTCY13E10.03), len: 493 aa.
IniC,isoniazid-inducible gene, (see citations below).
Shows slight similarity to P40983|YOR6_THER8 hypothetical
protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05,
(25.9% identity in 228 aa overlap). Also some similarity
to upstream ORF Rv0342|iniA. Contains (PS00017)
ATP/GTP-binding site motif A (P-loop). Note that the iniA
gene is also induced by the antibiotic ethambutol, an
agent that inhibits cell wall biosynthesis by a mechanism
that is distinct from isoniazid."
/db_xref="EnsemblGenomes-Gn:Rv0343"
/db_xref="EnsemblGenomes-Tr:CCP43073"
/db_xref="GOA:P9WJ95"
/db_xref="InterPro:IPR022812"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WJ95"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43073.1"
/translation="MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEP
LRIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRA
NVPITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLR
LLVPADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAG
RIDAMLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAER
TELNRALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAA
ELLERSGLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLL
ADTHAFEELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRA
ALAAAQHWRRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR"
gene complement(414381..414941)
/gene="lpqJ"
/locus_tag="Rv0344c"
CDS complement(414381..414941)
/codon_start=1
/transl_table=11
/gene="lpqJ"
/locus_tag="Rv0344c"
/product="Probable lipoprotein LpqJ"
/note="Rv0344c, (MTCY13E10.04c), len: 186 aa. Probable
lipoprotein, without homology. Has an appropriately
positioned prokaryotic lipoprotein signature (PS00013)."
/db_xref="EnsemblGenomes-Gn:Rv0344c"
/db_xref="EnsemblGenomes-Tr:CCP43074"
/db_xref="UniProtKB/TrEMBL:O06295"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP43074.1"
/translation="MRLSLIARGMAALLAATALVAGCNTTIDGRPVASPGSGPTEPTF
PTPRPTTAPPGTTAPTLPTTPVSPTAPAGAIPLPPDSNGYVFIETKSGMTRCQINRDS
VGCEAPFTNSPLRDGEHANGIHITAGGSVQWVLGNLGAIPTVSIDYRTYEAQGWTIDA
TTDGTRFTNNRTGHGMFVSIEKVDTF"
gene 415050..415460
/locus_tag="Rv0345"
CDS 415050..415460
/codon_start=1
/transl_table=11
/locus_tag="Rv0345"
/product="Conserved hypothetical protein"
/note="Rv0345, (MTCY13E10.05), len: 136 aa. Conserved
hypothetical protein, similar to other hypothetical
proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from
Streptomyces coelicolor (207 aa), FASTA scores: opt:
188,E(): 1.5e-05, (41.0% identity in 117 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0345"
/db_xref="EnsemblGenomes-Tr:CCP43075"
/db_xref="InterPro:IPR025877"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:O06296"
/protein_id="CCP43075.1"
/translation="MLPSTVVGVLLAAGAGRWYGKPKVLVDGWLDTAVGALRDGGCND
VILVLGAVEVSAPAGVTAITAPDWQQGLSASVRAGLAQADREHADYAVLHVIDTPDVN
AKVVARVLGRALVSRSGLAGRGRIPAHSARRRGC"
gene complement(415502..416965)
/gene="ansP2"
/gene_synonym="aroP2"
/locus_tag="Rv0346c"
CDS complement(415502..416965)
/codon_start=1
/transl_table=11
/gene="ansP2"
/gene_synonym="aroP2"
/locus_tag="Rv0346c"
/product="Possible L-asparagine permease AnsP2
(L-asparagine transport protein)"
/note="Rv0346c, (MTCY13E10.06c), len: 487 aa. Possible
ansP2, L-asparagine permease, integral membrane protein
belonging to family containing many amino acid
permeases,highly similar to
G467030|B2126_F2_85|NP_301937.1|NC_002677 probable
L-asparagine permease from Mycobacterium leprae (498 aa);
and NP_301938.1|NC_002677 probable L-asparagine permease
from Mycobacterium leprae (505 aa). Also highly similar to
others e.g. P77610|ANSP_ECOLI L-asparagine permease from
Escherichia coli strain K-12 (499 aa). Also highly similar
to ANSP1|Rv2127|MT2186|MTCY261_22|O33261 probable
L-asparagine permease from Mycobacterium tuberculosis (489
aa), FASTA score: (72.1% identity in 473 aa overlap). And
shows some similarity to MTCY3G12.14 from Mycobacterium
tuberculosis. Belongs to the amino acid permease family
(APC family). Note that previously known as aroP2."
/db_xref="EnsemblGenomes-Gn:Rv0346c"
/db_xref="EnsemblGenomes-Tr:CCP43076"
/db_xref="GOA:P9WQM7"
/db_xref="InterPro:IPR002293"
/db_xref="InterPro:IPR004840"
/db_xref="InterPro:IPR004841"
/db_xref="UniProtKB/Swiss-Prot:P9WQM7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43076.1"
/translation="MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGA
GGRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVA
GWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGE
LEFWASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVT
SGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAY
KEHVSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRF
TAPMSKTGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQ
LRLHRMANAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGV
PALIGGWYLVRNRVTAVAHHAIDHTKSVAVVHSADPI"
gene 417304..418290
/locus_tag="Rv0347"
CDS 417304..418290
/codon_start=1
/transl_table=11
/locus_tag="Rv0347"
/product="Probable conserved membrane protein"
/note="Rv0347, (MTCY13E10.07), len: 328 aa (alternative
start possible). Probable conserved membrane
protein,similar to Rv0831c|AL022004|MTV043_23 from
Mycobacterium tuberculosis (271 aa), FASTA scores: E():
9.6e-21, (33.1% identity in 266 aa overlap). This region
is a possible MT-complex-specific genomic island (See Becq
et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0347"
/db_xref="EnsemblGenomes-Tr:CCP43077"
/db_xref="GOA:O06298"
/db_xref="InterPro:IPR026349"
/db_xref="UniProtKB/TrEMBL:O06298"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43077.1"
/translation="MPGARELTLRVERGALFRRRWAASAASSARAAIRRDPRRCALGT
RPRWVSFLVIVLVIMNVVTAHPKYPNDPLALVLIELRHPRTEPPVPSAISILKEELAR
WTPILEQEEVRQVNLETGEHTAHSQKKLVARDRRTAITFRPDAMTLEVTDYPGWEEFR
SIVHAMVTARQDVAPVDGCIRIGLRYINEIRASLAEPSGWAYWVAESLLGPGTQLADL
KLTTTAQRHVIQCEGPEPGDSLTLRYAGARGAVIQSTPFLQRLKEPPAEGDFFLIDID
SAWSDPCKGIPALDAHLVDEVAERLHTPIGPLFESLITSELRTKVLQQPGQE"
gene 418293..418946
/locus_tag="Rv0348"
CDS 418293..418946
/codon_start=1
/transl_table=11
/locus_tag="Rv0348"
/product="Possible transcriptional regulatory protein"
/note="Rv0348, (MTCY13E10.08), len: 217 aa. Possible
transcriptional regulator, showing some similarity to
O53334|RV3188|MTV014.32 conserved hypothetical protein
from Mycobacterium tuberculosis (115 aa), FASTA score:
(30.0% identity in 100 aa overlap). Contains probable
helix-turn helix motif from aa 89-110 (Score 1407, +3.98
SD). This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0348"
/db_xref="EnsemblGenomes-Tr:CCP43078"
/db_xref="UniProtKB/TrEMBL:O06299"
/protein_id="CCP43078.1"
/translation="MTISFSSSNLRDDATSGNGDYRLDKLPETTPSTSVFDRADVTYR
QFTELHGQARDTRREAHVVELESKTGERARCAPMHALEQLADYGFAWRDIARVVGVSV
PAITKWRKGAGVTGENRLKIARLLALIDMLSDRFIGEPASWLEMPIQAGVGITRMDLL
ERGRYDLVLALASTHTGDGTVEYVLNETDKDWRETVVDNAFESYTAEDGVISIRPKR"
gene 418949..419608
/locus_tag="Rv0349"
CDS 418949..419608
/codon_start=1
/transl_table=11
/locus_tag="Rv0349"
/product="Hypothetical protein"
/note="Rv0349, (MTCY13E10.09), len: 219 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0349"
/db_xref="EnsemblGenomes-Tr:CCP43079"
/db_xref="UniProtKB/TrEMBL:O06300"
/protein_id="CCP43079.1"
/translation="MPELETPDDPESIYLARLEDVGEHRPTFTGDIYRLGDGRMVMIL
QHPCALRHGVDLHPRLLVAPVRPDSLRSNWARAPFGTMPLPKLIDGQDHSADFINLEL
IDSPTLPTCERIAVLSQSGVNLVMQRWVYHSTRLAVPTHTYSDSTVGPFDEADLIEEW
VTDRVDDGADPQAAEHECASWLDERISGRTRRALLSDRQHASSIRREARSHRKSVKLA
D"
gene 419835..421712
/gene="dnaK"
/gene_synonym="hsp70"
/locus_tag="Rv0350"
CDS 419835..421712
/codon_start=1
/transl_table=11
/gene="dnaK"
/gene_synonym="hsp70"
/locus_tag="Rv0350"
/product="Probable chaperone protein DnaK (heat shock
protein 70) (heat shock 70 kDa protein) (HSP70)"
/note="Rv0350, (MTCY13E10.10), len: 625 aa. Probable dnaK
(alternate gene name: hsp70), 70 kDa heat shock protein
(see citations below), equivalent to
AAA25362.1|M95576|1924344A|738248 heat shock protein 70
from Mycobacterium leprae (621 aa); and DNAK_MYCPA|Q00488
(623 aa), FASTA scores: opt: 3678, E(): 0, (92.3% identity
in 625 aa overlap). Also highly similar to others e.g.
Q05558|DNAK_STRCO|453231|CAA54606.1|X77458 chaperone
protein DNAK from Streptomyces coelicolor (618 aa). Has
probably an ATPase activity. Note that this sequence
differs from DNAK_MYCTU|P32723 (609 aa), due to a
frameshift near the N-terminus. Belongs to the heat shock
protein 70 family."
/db_xref="EnsemblGenomes-Gn:Rv0350"
/db_xref="EnsemblGenomes-Tr:CCP43080"
/db_xref="GOA:P9WMJ9"
/db_xref="InterPro:IPR012725"
/db_xref="InterPro:IPR013126"
/db_xref="InterPro:IPR018181"
/db_xref="InterPro:IPR029047"
/db_xref="InterPro:IPR029048"
/db_xref="UniProtKB/Swiss-Prot:P9WMJ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43080.1"
/translation="MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFAR
NGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRD
AEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKG
EKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKG
TSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRA
EFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKE
PNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTI
PTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTF
DIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEAD
VRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSA
MEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREA
K"
gene 421709..422416
/gene="grpE"
/locus_tag="Rv0351"
CDS 421709..422416
/codon_start=1
/transl_table=11
/gene="grpE"
/locus_tag="Rv0351"
/product="Probable GrpE protein (HSP-70 cofactor)"
/note="Rv0351, (MTCY13E10.11), len: 235 aa. Probable grpE
protein (HSP-70 cofactor), equivalent to
CAC32012.1|AL583925 Hsp70 cofactor from Mycobacterium
leprae (229 aa). Also highly similar to others eg
Q05562|GRPE_STRCO|2127521|PN0643 GRPE protein from
Streptomyces coelicolor (225 aa). Contains grpE protein
signature (PS01071). Belongs to the GrpE family."
/db_xref="EnsemblGenomes-Gn:Rv0351"
/db_xref="EnsemblGenomes-Tr:CCP43081"
/db_xref="GOA:P9WMT5"
/db_xref="InterPro:IPR000740"
/db_xref="InterPro:IPR009012"
/db_xref="InterPro:IPR013805"
/db_xref="UniProtKB/Swiss-Prot:P9WMT5"
/inference="protein motif:PROSITE:PS01071"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43081.1"
/translation="MTDGNQKPDGNSGEQVTVTDKRRIDPETGEVRHVPPGDMPGGTA
AADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDL
ERARKHGDLESGPLKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGS
KPVIGTVMRQGYQLGEQVLRHALVGVVDTVVVDAAELESVDDGTAVADTAENDQADQG
NSADTSGEQAESEPSGS"
gene 422452..423639
/gene="dnaJ1"
/gene_synonym="dnaJ"
/locus_tag="Rv0352"
CDS 422452..423639
/codon_start=1
/transl_table=11
/gene="dnaJ1"
/gene_synonym="dnaJ"
/locus_tag="Rv0352"
/product="Probable chaperone protein DnaJ1"
/note="Rv0352, (MTCY13E10.12), len: 395 aa. Probable
dnaJ1,chaperone protein, equivalent to AAA25363.1|M95576
DNA J heatshock protein from Mycobacterium leprae (389
aa). Also highly similar to others. Contains both DnaJ
signatures (PS00636, and PS00637). Belongs to the DNAJ
family. Cofactor: binds two zinc ions per monomer. Note
that sequence differs from DNAJ_MYCTU|P07881 due to a
frameshift at the N-terminus. Note that previously known
as dnaJ."
/db_xref="EnsemblGenomes-Gn:Rv0352"
/db_xref="EnsemblGenomes-Tr:CCP43082"
/db_xref="GOA:P9WNV9"
/db_xref="InterPro:IPR001305"
/db_xref="InterPro:IPR001623"
/db_xref="InterPro:IPR002939"
/db_xref="InterPro:IPR008971"
/db_xref="InterPro:IPR012724"
/db_xref="InterPro:IPR018253"
/db_xref="InterPro:IPR036410"
/db_xref="InterPro:IPR036869"
/db_xref="UniProtKB/Swiss-Prot:P9WNV9"
/inference="protein motif:PROSITE:PS00636"
/inference="protein motif:PROSITE:PS00637"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43082.1"
/translation="MAQREWVEKDFYQELGVSSDASPEEIKRAYRKLARDLHPDANPG
NPAAGERFKAVSEAHNVLSDPAKRKEYDETRRLFAGGGFGGRRFDSGFGGGFGGFGVG
GDGAEFNLNDLFDAASRTGGTTIGDLFGGLFGRGGSARPSRPRRGNDLETETELDFVE
AAKGVAMPLRLTSPAPCTNCHGSGARPGTSPKVCPTCNGSGVINRNQGAFGFSEPCTD
CRGSGSIIEHPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSGD
LYVTVHVRPDKIFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGTVGVRVPKGTADGR
ILRVRGRGVPKRSGGSGDLLVTVKVAVPPNLAGAAQEALEAYAAAERSSGFNPRAGWA
GNR"
gene 423639..424019
/gene="hspR"
/locus_tag="Rv0353"
CDS 423639..424019
/codon_start=1
/transl_table=11
/gene="hspR"
/locus_tag="Rv0353"
/product="Probable heat shock protein transcriptional
repressor HspR (MerR family)"
/note="Rv0353, (MTCY13E10.13), len: 126 aa. Probable
hspR,heat shock regulatory protein (see Stewart et al.,
2001),merR family, highly similar to others e.g.
HspR|P40183 heat shock regulatory protein from
Streptomyces coelicolor (151 aa), FASTA scores: E():
4.9e-22, (55.7% identity in 140 aa overlap), that binds to
three inverted repeats (IR1-IR3) in the promoter region of
the dnaK operon. Has possible coiled coil region in
C-terminal half. Belongs to the MerR family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv0353"
/db_xref="EnsemblGenomes-Tr:CCP43083"
/db_xref="GOA:O06302"
/db_xref="InterPro:IPR000551"
/db_xref="InterPro:IPR009061"
/db_xref="UniProtKB/TrEMBL:O06302"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43083.1"
/translation="MAKNPKDGESRTFLISVAAELAGMHAQTLRTYDRLGLVSPRRTS
GGGRRYSLHDVELLRQVQHLSQDEGVNLAGIKRIIELTSQVEALQSRLQEMAEELAVL
RANQRREVAVVPKSTALVVWKPRR"
gene complement(424269..424694)
/gene="PPE7"
/locus_tag="Rv0354c"
CDS complement(424269..424694)
/codon_start=1
/transl_table=11
/gene="PPE7"
/locus_tag="Rv0354c"
/product="PPE family protein PPE7"
/note="Rv0354c, (MTCY13E10.14c), len: 141 aa. PPE7, Member
of the Mycobacterium tuberculosis PPE family, similar to
others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411
aa), FASTA scores: E(): 3.6e-11, (47.6% identity in 103 aa
overlap). Possible continuation of ORF upstream, but no
sequence error apparent."
/db_xref="EnsemblGenomes-Gn:Rv0354c"
/db_xref="EnsemblGenomes-Tr:CCP43084"
/db_xref="UniProtKB/TrEMBL:L0T545"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43084.1"
/translation="MSVCVIYIPFKGCVKHVSVTIPITTEHLGPYEIDASTINPDQPI
DTAFTQTLDFAGSGTVGAFPFGFGWQQSPGFFNSTTTPSSGFFNSGAGGASGFLNDAA
AAVSGLGNVFTETSGFFNAGGVGIRASKTSATCCRAGRT"
gene complement(424777..434679)
/gene="PPE8"
/locus_tag="Rv0355c"
CDS complement(424777..434679)
/codon_start=1
/transl_table=11
/gene="PPE8"
/locus_tag="Rv0355c"
/product="PPE family protein PPE8"
/note="Rv0355c, (MTCY13E10.15c,
MTCY13E10.16c,MTCY13E10.17c), len: 3300 aa. PPE8, Member
of the Mycobacterium tuberculosis PPE family, similar to
others e.g. AL009198|MTV004_5 from Mycobacterium
tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0,
(40.9% identity in 3833 aa overlap); MTV004_3 FASTA
scores: (39.0% identity in 3531 aa overlap); etc. Gene
contains large number of clustered Major Polymorphic
Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0;
MTCY13E10.17c, E(): 0; MTCY48.17,E(): 0; MTCY98.0034c,
E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0;
MTCY31.06c, E(): 5.6e-17; MTCY359.33,E(): 2.3e-16.
Nucleotide position 426909 in the genome sequence has been
corrected, A:C resulting in W2591G."
/db_xref="EnsemblGenomes-Gn:Rv0355c"
/db_xref="EnsemblGenomes-Tr:CCP43085"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:I6Y7L4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43085.1"
/translation="MSFAVLPPEINSARLYVGAGLAPMLDAAAAWDGLADELGSAAAS
FSAVTAGLAGSSWLGAASTAMTGAAAPYLGWLSAAAAQAQQAATQTRLAAAAFEAALA
ATVHPAIISANRALFVSLVVSNLLGQNAPAIAATEAAYEQMWAQDVAAMFGYHAGASA
AVSALTPFGQALPTVAGGGALVSAAAAQVTTRVFRNLGLANVGEGNVGNGNVGNFNLG
SANIGNGNIGSGNIGSSNIGFGNVGPGLTAALNNIGFGNTGSNNIGFGNTGSNNIGFG
NTGDGNRGIGLTGSGLLGFGGLNSGTGNIGLFNSGTGNVGIGNSGTGNWGIGNSGNSY
NTGFGNSGDANTGFFNSGIANTGVGNAGNYNTGSYNPGNSNTGGFNMGQYNTGYLNSG
NYNTGLANSGNVNTGAFITGNFNNGFLWRGDHQGLIFGSPGFFNSTSAPSSGFFNSGA
GSASGFLNSGANNSGFFNSSSGAIGNSGLANAGVLVSGVINSGNTVSGLFNMSLVAIT
TPALISGFFNTGSNMSGFFGGPPVFNLGLANRGVVNILGNANIGNYNILGSGNVGDFN
ILGSGNLGSQNILGSGNVGSFNIGSGNIGVFNVGSGSLGNYNIGSGNLGIYNIGFGNV
GDYNVGFGNAGDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNIASGWNSGTG
NSGLFNSGTNNVGIFNAGTGNVGIANSGTGNWGIGNPGTDNTGILNAGSYNTGILNAG
DFNTGFYNTGSYNTGGFNVGNTNTGNFNVGDTNTGSYNPGDTNTGFFNPGNVNTGAFD
TGDFNNGFLVAGDNQGQIAIDLSVTTPFIPINEQMVIDVHNVMTFGGNMITVTEASTV
FPQTFYLSGLFFFGPVNLSASTLTVPTITLTIGGPTVTVPISIVGALESRTITFLKID
PAPGIGNSTTNPSSGFFNSGTGGTSGFQNVGGGSSGVWNSGLSSAIGNSGFQNLGSLQ
SGWANLGNSVSGFFNTSTVNLSTPANVSGLNNIGTNLSGVFRGPTGTIFNAGLANLGQ
LNIGSANLGDFNLGSGNVGSFNVFSGNQGSYNIGPANLGNYNIGFANLGNYNIGFGNA
GDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGTANIGLFNSGTN
NVGIGNSGTGNWGIGNSGSGNTGIGNTGSTNTGFFNTGIVNTGVANAGSYNTGWYNTG
DTNTGIANLGDFNTGFYNTGNFSTGFANQGDIATGAFITGDMGNGAFWRGDQQGLFSA
GYRVHVPEIPAHVTVEVPVNIPITASFTNTVYSGITLEQINFGFTIDIAGIPLLAGAI
SKAVLPPITGTGPAITVNIGDPGGSTAIRIPATASVGPFDVTFVNIAATTGFFNATTD
PSSGFFNGGPGTVSGIANIGANISGFQNVANSATSGFNNYGSLQSGLANLGDTVSGVF
NTGIGAPANVSGMFNIGSNLAGFFHDQATGMSMFNLGLGNIGQFNVGFSNVGDSNAGL
ANIGSFNLGSGNLGSFNVFGGNQGSYNIGPANLGNYNIGLGNLGSYNFGFGNAGDFNL
GFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNFAGGWNSGSGNSGLFNSGTNNIGLF
NSGTGNIGIGNSGTGNWGIANTGDTNTGIFNTGDVNTGLLNAGNVNTGIFNTGHYNTG
SFNAGSFNTAGFNPGSYNTGYLNTGSYNTGLANSGDVNTGGFITGNYSNGFWWRGDYQ
GLAGISQTITVPDTAVPVKLHVPIFLDIPVTGTLGTFTVHGFRFPEITGDIFLIGIPF
NAATLDAFSFPNISIVLPNIGINLGSGPDPLIDIAGTGGLLPIKIPLIDIPAAPGFGN
STTTPSSGFFNAGTGTVSGVGNVGSNSSGFFNLTSGSSGISGVQNFGELISGGFNFGN
TVSGLVNASTLGLSMPANLSGGGNVGATVAGFVNNTQILNLGFGNVGSGNVGHGNIGD
SNVGLGNLGNANVGHGNIGSFNVFSGNRGSYNIGPANLGNYNIGLGNLGSYNFGFGNA
GDFNLGFANSGSNNIGFANTGNNNIGIGLSGHNQQGFGSWNSGTANTGLFNSGTNNIG
LFNSGTGNIGIGNSGIGNTGIGNPGVGNTGLGNSGTGNWGLWNPGTGNMGVANVGTYN
TGGYNVGSTNTGIANVGIANTGSYNTGSTNTGSFNDGDFNTGFYNTGDYNTGFYNTGD
VNTGAFIGGNFSNGAFWQSDHQGQWGAHYAITVPQIPLLNFSLNIPVNIPIHLDFGTL
AVNGFQIPAITLRALGVTHFSVGPIIVPRIAGTLPVIDINIGDPGGSSSIPITITSGA
GPVVIPLLDIPPAPGFGNSTTGPSSGFFNSGTGSSSGFGNVGANNSGFWNTAFAGIGN
SGLQNFGSLQSGWANLGNTVSGFYNTSAADFATPANLSGLSNVGADLTGVLRGPNGST
FNAGLANLGQFNVGSANLGSANLGSANLGSANLGNSNVGFGNIGNANIGGANIGDFNV
GIANTGPGLTAAVNNIGIGNTGNYNIGVGNTGNYNIGFGNTGNNNIGIGLSGDNQIGF
GPLNAGIANMGLFNLGDNNFGMANAGNFNQGIANTGNNNIGLFNTGNNNVGIGLTGDG
LSGFSSLNSGAGNTGFFNSGTANTGLFNSGTGNTGLFNSGTGNVGIGNMGTGGFGVGL
SGDSQVGIGGTNSGSFNIGLFNSGTGNVGIGNSGTGNVGIGNTGTGNTGIGNSGNYNT
GLLNAGLVNTGIANPGNHNTGLFNIGTFNTGIANPGHYNTGSYNTGSYNTGMANAGDY
GTGAFITGSMNNGLLWRADRQGLLAANYTITIERPAAFLNVDIPVNIPITGDITNVSI
PAITFPRIDASGSVDIGILSGTVLAPVGPITLHGGDASAPLDTPIEIDFGPSPAINLN
IGKPDGSTVINIVGGAGAGPISIPIIDLRPAPGFFNATTGPSSGFLNWGAGSASGLLN
FGNNSGLYNFATSSMGNSGFQNYGSLQSGWANLGNSISGIYNTGLGAPANVSGLLNIG
TNLAGWLQNGPTETTFSVGLANLGFWNLGSANIGNYNLGSANIGVYNLGSANIGDFNL
GSANIGDFNLGSANIGSSNIGFGNVGPGLTAAIGNIGFGNTGNGNIGIGNTGTGNIGF
GNTGNGNIGIGLTGDTMTGFGGWNSGTGNIGLFNSGTGNIGFGNSGTGNWGIGNSGDY
NTGIGNTGSTNSGFFNTGLVNTGIGNSGDYNTGLFNAGNTNTGSFNPGDYNTGGFNPG
NYNTGYFNPGNSNTGIANSGDVNTGAFNSGNYSNGFFWRGDYQGLGGFAYQSAVSEIP
WSYDRFQH"
gene complement(434830..435474)
/locus_tag="Rv0356c"
CDS complement(434830..435474)
/codon_start=1
/transl_table=11
/locus_tag="Rv0356c"
/product="Conserved protein"
/note="Rv0356c, (MTCY13E10.18c), len: 214 aa. Conserved
protein, equivalent to AL023514|MLCB4_12 conserved
hypothetical protein from Mycobacterium leprae (218
aa),FASTA scores: opt: 1067, E(): 0, (73.4% identity in
214 aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0356c"
/db_xref="EnsemblGenomes-Tr:CCP43086"
/db_xref="InterPro:IPR006683"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:O06307"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43086.1"
/translation="MTDASVHPDELDPEYHHHGGFPEYGPASPGAGFGQFVATMRRLQ
DLAVAADPGDAVWDEAAERAAALVELLSPFEADEGKAPAGRTPGLPGMGSLLLPPWTV
TRYGTDGVEMRGSFSRFHVGGNSAVHGGVLPLLFDHMFGMISHAAGRPISRTAFLHVD
YRRITPIDVPLIVRGRVTNTEGRKAFVCAELFDSDETLLAEGNGLMVRLLPGQP"
gene complement(435471..436769)
/gene="purA"
/locus_tag="Rv0357c"
CDS complement(435471..436769)
/codon_start=1
/transl_table=11
/gene="purA"
/locus_tag="Rv0357c"
/product="Probable adenylosuccinate synthetase PurA
(imp--aspartate ligase) (ADSS) (ampsase)"
/note="Rv0357c, (MTCY13E10.19c), len: 432 aa. Probable
purA, adenylosuccinate synthase, equivalent to
AL023514|MLCB4_13 from adenylosuccinate synthetase
Mycobacterium leprae (432 aa), FASTA scores: opt:
2555,E(): 0, (87.9% identity in 431 aa overlap). Also
highly similar to many bacterial adenylosuccinates
synthetases e.g. P12283|PURA_ECOLI adenylosuccinates
synthetase from Escherichia coli (431 aa), FASTA scores:
E(): 0, (51.1% identity in 425 aa overlap); etc. Belongs
to the adenylosuccinate synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv0357c"
/db_xref="EnsemblGenomes-Tr:CCP43087"
/db_xref="GOA:P9WHN3"
/db_xref="InterPro:IPR001114"
/db_xref="InterPro:IPR018220"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR033128"
/db_xref="InterPro:IPR042109"
/db_xref="InterPro:IPR042110"
/db_xref="InterPro:IPR042111"
/db_xref="UniProtKB/Swiss-Prot:P9WHN3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43087.1"
/translation="MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVV
LPTGENFALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLISAD
AHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVADVLDPEQLTHK
VEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNAALEAGETV
LLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSG
PFPTELFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDV
LSSLESVPVCVGYEIDGRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPA
KARDYVLRLEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP"
gene 436860..437507
/locus_tag="Rv0358"
CDS 436860..437507
/codon_start=1
/transl_table=11
/locus_tag="Rv0358"
/product="Conserved protein"
/note="Rv0358, (MTCY13E10.20), len: 215 aa. Conserved
protein, highly similar to ML0281|AL023514|MLCB4_14
conserved hypothetical protein from Mycobacterium leprae
(229 aa), FASTA scores: opt: 852, E(): 0, (62.9% identity
in 229 aa overlap). A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0358"
/db_xref="EnsemblGenomes-Tr:CCP43088"
/db_xref="UniProtKB/TrEMBL:O06308"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43088.1"
/translation="MYTAENAPGVAVLLSGDADVPGPLTGLPTHQDNLDTVIGRYSRL
IVVGADADLGAVLTRLLRTDRLDVEVGYVPRRRSPATRAYRLPAGRRAARRARCGVAR
RVPLIRDETGSVIVGRAQWLPAEEQALIHGEAVVDDTVLFDGDVAGVCIEPTLTLPGL
RAAVDGAGKWRRWIGGRAAQLGTTGAAVLRDGVAAPRPVRRSTFYRNVEGWLLVR"
gene 437518..438297
/locus_tag="Rv0359"
CDS 437518..438297
/codon_start=1
/transl_table=11
/locus_tag="Rv0359"
/product="Probable conserved integral membrane protein"
/note="Rv0359, (MTCY13E10.21), len: 259 aa. Probable
conserved integral membrane protein, highly similar to
hypothetical or other membrane proteins e.g.
AL133220|SCC75A_6|T50569 probable membrane protein from
Streptomyces coelicolor (265 aa), FASTA scores: opt:
642,E(): 0, (43.1% identity in 248 aa overlap); P70995
hypothetical 24.7 kDa protein from Bacillus subtilis (219
aa), FASTA scores: E(): 1.5e-12, (31.3% identity in 192 aa
overlap). Contains neutral zinc
metallopeptidases,zinc-binding region signature
(PS00142)."
/db_xref="EnsemblGenomes-Gn:Rv0359"
/db_xref="EnsemblGenomes-Tr:CCP43089"
/db_xref="GOA:L0T550"
/db_xref="UniProtKB/Swiss-Prot:L0T550"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43089.1"
/translation="MSETGQRESVRPSPIFLGLLGLTAVGGALAWLAGETVQPLAYAG
VFVMVIAGWLVSLCLHEFGHAFTAWRFGDHDVAVRGYLTLDPRRYSHPMLSLGLPMLF
IALGGIGLPGAAVYVHTWFMTTARRTLVSLAGPTVNLALAMLLLAATRLLFDPIHAVL
WAGVAFLAFLQLTALVLNLLPIPGLDGYAALEPHLRPETQRALAPAKQFALVFLLVLF
LAPTLNGWFFGVVYWLFDLSGVSHRLAAAGSVLARFWSIWF"
gene complement(438302..438739)
/locus_tag="Rv0360c"
CDS complement(438302..438739)
/codon_start=1
/transl_table=11
/locus_tag="Rv0360c"
/product="Conserved protein"
/note="Rv0360c, (MTCY13E10.22c), len: 145 aa. Conserved
protein, equivalent to
AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c
hypothetical protein from Mycobacterium leprae (137
aa),FASTA scores: opt: 793, E(): 0, (85.4% identity in 137
aa overlap). And similar to AL049754|SCH10_25c|T36537
hypothetical protein from Streptomyces coelicolor (143
aa),FASTA scores: opt: 497, E(): 3.2e-27, (55.8% identity
in 138 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0360c"
/db_xref="EnsemblGenomes-Tr:CCP43090"
/db_xref="InterPro:IPR014487"
/db_xref="UniProtKB/TrEMBL:O06310"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43090.1"
/translation="MTKRTITPMTSMGDLLGPEPILLPGDSDAEAELLANESPSIVAA
AHPSASVAWAVLAEGALADDKTVTAYAYARTGYHRGLDQLRRHGWKGFGPVPYSHQPN
RGFLRCVAALARAAAAIGETDEYGRCLDLLDDCDPAARPALGL"
gene 438822..439649
/locus_tag="Rv0361"
CDS 438822..439649
/codon_start=1
/transl_table=11
/locus_tag="Rv0361"
/product="Probable conserved membrane protein"
/note="Rv0361, (MTCY13E10.23), len: 275 aa. Probable
conserved membrane protein (has hydrophobic stretch from
residues 132-156), equivalent to
AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane
protein from Mycobacterium leprae (292 aa), FASTA scores:
opt: 1044, E(): 0, (58.6% identity in 292 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0361"
/db_xref="EnsemblGenomes-Tr:CCP43091"
/db_xref="GOA:O06311"
/db_xref="InterPro:IPR032710"
/db_xref="UniProtKB/TrEMBL:O06311"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43091.1"
/translation="MSNAPEPDRSAGESGSEPAGERSADPGEERTESYPLVPHDAETE
TVVITTSDNDAAVTQPEAQRERRFTAPGFDAKETQVIVTAHEAATEVFQTNQAPTTPP
RMPTGMPPKTAVPQSIPPRTEATSVRQRTWGWALAVVVIVLALAAIAILGTVLLTRGK
HSKMSQEDQVRQAIQSLDIAIQTGDLTALRSLTCGSTRDGYVDYDERDWAETYRRVSA
AKQYPVIASIDQVVVNGAHAEANVTTFMAFDPQVRSTRSLDLQFRDDQWKICQSSSN"
gene 439871..441253
/gene="mgtE"
/locus_tag="Rv0362"
CDS 439871..441253
/codon_start=1
/transl_table=11
/gene="mgtE"
/locus_tag="Rv0362"
/product="Possible Mg2+ transport transmembrane protein
MgtE"
/note="Rv0362, (MTCY13E10.24), len: 460 aa. Possible
mgtE,magnesium (Mg2+) transport transmembrane protein;
C-terminal region is highly similar to MGTE|G780283
putative Mg2+ transporter from Providencia stuarti (314
aa), FASTA scores: E(): 0, (47.2% identity in 307 aa
overlap) (N-terminus extends approx. 150 aa further
upstream compared to P. stuarti ORF). Also similar in part
to others e.g. AAK20879.1|AF334760_1|AF334760 putative
Mg2+ transporter from Aeromonas hydrophila (455 aa);
NP_231292.1|NC_002505 magnesium transporter from Vibrio
cholerae (451 aa); NP_102305.1|NC_002678 Mg2+ transport
protein from Mesorhizobium loti (454 aa); etc. Also
similar to Rv1232c|MTV006.04c from Mycobacterium
tuberculosis (435 aa). Extended hydrophobic segment
spanning last 130 residues. Belongs to the MgtE family."
/db_xref="EnsemblGenomes-Gn:Rv0362"
/db_xref="EnsemblGenomes-Tr:CCP43092"
/db_xref="GOA:O06312"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR006667"
/db_xref="InterPro:IPR006668"
/db_xref="InterPro:IPR006669"
/db_xref="InterPro:IPR036739"
/db_xref="InterPro:IPR038048"
/db_xref="InterPro:IPR038076"
/db_xref="UniProtKB/TrEMBL:O06312"
/protein_id="CCP43092.1"
/translation="MSIRPAENSTLDIRHVIGIGTPKAVDLWLDVVTELPDRARELGS
LSKAELGKLGPLLDGTNAVELFESIDDKLAAEALHAMDPSLAATFLEALDSDHAANIL
REFKEPKREALLTLLPLERAMVLRGLLSWPEDCAAAHMVPETLTVRPNMTVSQAVASV
RERASGLRSDARTTAYVYVTDADSHLLGVIAFRALVLANPEQRVRELMGDDLIVVSPL
TDKELAAQTIMGHNLMAVPVVDADNRLLGIIAEDEAIDIAEEEATEDAERQGGSAPLE
VPYLRASPWLLWRKRVVWLLVLFAAEAYTGSVLRAFSDEMEAVIALAFFIPLLIGTGG
NTGTQIATTLVRAMATGQVRFRDVPAVLAKELSTGVLVGLTMAAAAVVRAWTLGVGPQ
VTLTVALTVAAIVVWSSLVAAVLPPLLKKLRIDPAIVSGPMIATIVDGTGLLIYFLVA
HLTLTELHGL"
gene complement(441265..442299)
/gene="fba"
/gene_synonym="fda"
/locus_tag="Rv0363c"
CDS complement(441265..442299)
/codon_start=1
/transl_table=11
/gene="fba"
/gene_synonym="fda"
/locus_tag="Rv0363c"
/product="Probable fructose-bisphosphate aldolase Fba"
/note="Rv0363c, (MTCY13E10.25c), len: 344 aa. Probable fba
(alternate gene name: fda), fructose bisphosphate aldolase
, equivalent to AL023514|MLCB4_18|O69600|ALF_MYCLE
fructose-bisphosphate aldolase from Mycobacterium leprae
(345 aa), FASTA scores: opt: 1995, E(): 0, (87.7% identity
in 342 aa overlap). Also highly similar to others. Belongs
to class II fructose-bisphosphate aldolase family.
Cofactor: zinc."
/db_xref="EnsemblGenomes-Gn:Rv0363c"
/db_xref="EnsemblGenomes-Tr:CCP43093"
/db_xref="GOA:P9WQA3"
/db_xref="InterPro:IPR000771"
/db_xref="InterPro:IPR006411"
/db_xref="InterPro:IPR013785"
/db_xref="PDB:3EKL"
/db_xref="PDB:3EKZ"
/db_xref="PDB:3ELF"
/db_xref="PDB:4A21"
/db_xref="PDB:4A22"
/db_xref="PDB:4DEF"
/db_xref="PDB:4DEL"
/db_xref="PDB:4LV4"
/db_xref="UniProtKB/Swiss-Prot:P9WQA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43093.1"
/translation="MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADA
GSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKL
DSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEI
EIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPG
NVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVD
TDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACND
LHCAGKSLTH"
gene 442395..443078
/locus_tag="Rv0364"
CDS 442395..443078
/codon_start=1
/transl_table=11
/locus_tag="Rv0364"
/product="Possible conserved transmembrane protein"
/note="Rv0364, (MTCY13E10.26), len: 227 aa. Possible
conserved transmembrane protein, equivalent to
O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLCB
4_19 hypothetical 24.3 KDA protein from Mycobacterium
leprae (222 aa), FASTA scores: opt: 1027, E(): 0, (66.1%
identity in 227 aa overlap). Shows strong similarity to
DEDA_ECOLI|P09548 DedA protein protein from Escherichia
coli FASTA scores: E(): 1.3e-28, (39.5% identity in 195 aa
overlap). Similar also to Mycobacterium tuberculosis DedA
protein Rv2637|MTCY441.0."
/db_xref="EnsemblGenomes-Gn:Rv0364"
/db_xref="EnsemblGenomes-Tr:CCP43094"
/db_xref="GOA:P9WP09"
/db_xref="InterPro:IPR032816"
/db_xref="InterPro:IPR032818"
/db_xref="UniProtKB/Swiss-Prot:P9WP09"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43094.1"
/translation="MSTAVTAMPDILDPMYWLGANGVFGSAVLPGILIIVFIETGLLF
PLLPGESLLFTGGLLSASPAPPVTIGVLAPCVALVAVLGDQTAYFIGRRIGPALFKKE
DSRFFKKHYVTESHAFFEKYGKWTIILARFVPIARTFVPVIAGVSYMRYPVFLGFDIV
GGVAWGAGVTLAGYFLGSVPFVHMNFQLIILAIVFVSLLPALVSAARVYRARRNAPQS
DPDPLVLPE"
gene complement(443067..444197)
/locus_tag="Rv0365c"
CDS complement(443067..444197)
/codon_start=1
/transl_table=11
/locus_tag="Rv0365c"
/product="Conserved protein"
/note="Rv0365c, (MTCY13E10.27c), len: 376 aa (start
uncertain). Conserved protein (see citation below), very
similar to G388212|CAA35191.1, a truncated ORF immediately
upstream of the Corynebacterium glutamicum fda gene
encoding fructose-1,6-biphosphate aldolase (304 aa), FASTA
scores: E(): 7.1e-19, (42.2% identity in 296 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0365c"
/db_xref="EnsemblGenomes-Tr:CCP43095"
/db_xref="GOA:O06315"
/db_xref="InterPro:IPR005198"
/db_xref="InterPro:IPR008928"
/db_xref="InterPro:IPR014512"
/db_xref="UniProtKB/TrEMBL:O06315"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43095.1"
/translation="MNLANRAASAETAVTQRHLRRLWALPGTQLAVVAWPSTRRDRLF
GSWHYWWQAHLLDCLVDAQLRDPQPQRRARINRQVRSHRVRNNFSWLNSYYDDMAWLA
LALERADRVAGVRRRRALPKLTNQFVEAWVPEDGGGIPWRKQDQFFNAPANGPAGLFL
ARYPDQYGKRLKRAEQMADWIDRTLIDPETHLVFDGIKAGSLVRAQYTYCQGVVLGLE
TELAVRTGPAARARHCARVHRLVAAVNEHMAPLGVLRGAGGGDGGLFAGITARYLALV
ATTLPGDSADDAAARDTARAIVLASAQSAWDYRQTVDGLPVFGAFWDREAELPTAGGE
QARSVRGAVHSSAIAERDLSVQLSGWMLMEAAHSAAAVSSLG"
gene complement(444222..444815)
/locus_tag="Rv0366c"
CDS complement(444222..444815)
/codon_start=1
/transl_table=11
/locus_tag="Rv0366c"
/product="Conserved hypothetical protein"
/note="Rv0366c, (MTV036.01c), len: 197 aa. Conserved
hypothetical protein, showing weak similarity to
HI1395|P44173|YD95_HAEIN hypothetical protein from
Haemophilus influenzae (140 aa), FASTA scores: opt:
152,E(): 0.0015, (27.0% identity in 126 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A (P-loop) and
PS00850 Glycine radical signature."
/db_xref="EnsemblGenomes-Gn:Rv0366c"
/db_xref="EnsemblGenomes-Tr:CCP43096"
/db_xref="GOA:O53701"
/db_xref="InterPro:IPR010488"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O53701"
/inference="protein motif:PROSITE:PS00850"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43096.1"
/translation="MKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWP
DDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSHPSKLELIRTARTAGYTVVLHVL
VIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA"
gene complement(444844..445233)
/locus_tag="Rv0367c"
CDS complement(444844..445233)
/codon_start=1
/transl_table=11
/locus_tag="Rv0367c"
/product="Hypothetical protein"
/note="Rv0367c, (MTV036.02c), len: 129 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0367c"
/db_xref="EnsemblGenomes-Tr:CCP43097"
/db_xref="InterPro:IPR021831"
/db_xref="UniProtKB/TrEMBL:O53702"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43097.1"
/translation="MPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAV
SNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEISAAIEERLSRTNYGDVLAAQGI
TTVALNDAGDIVEHRPDGTSVVLAATP"
gene complement(445314..446525)
/locus_tag="Rv0368c"
CDS complement(445314..446525)
/codon_start=1
/transl_table=11
/locus_tag="Rv0368c"
/product="Conserved hypothetical protein"
/note="Rv0368c, (MTV036.03c), len: 403 aa. Conserved
hypothetical protein, showing some similarity to
AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium
japonicum (422 aa), FASTA scores: opt: 341, E():
4.3e-13,(27.4% identity in 387 aa overlap);
Rv2425c|MTCY428_22 hypothetical protein from Mycobacterium
tuberculosis FASTA score: (30.7% identity in 238 aa
overlap). Contains PS00213 Lipocalin signature."
/db_xref="EnsemblGenomes-Gn:Rv0368c"
/db_xref="EnsemblGenomes-Tr:CCP43098"
/db_xref="GOA:O53703"
/db_xref="InterPro:IPR002035"
/db_xref="InterPro:IPR008912"
/db_xref="InterPro:IPR011195"
/db_xref="InterPro:IPR036465"
/db_xref="UniProtKB/TrEMBL:O53703"
/inference="protein motif:PROSITE:PS00213"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43098.1"
/translation="MATPALLPGVDLAAFAAALAARLRDAGIPVSASGQASLVQALQQ
LVPRTPAALYWGARLTLVSRVDELATFDAVFASLFGVFGSAEPDGANRPPPPIAGPRT
PVAGVGHRAKRRSCAAQAQNLPWDTRSLTMASAGQGGPSRTLPDVLPSRIVARADEPF
DQFDPDDLRLLGAWLEATMARWPRRRSMRFESSPHGKRIDLRATMNASRSTGWESVLL
ARIRPRRRPRRVLLLCDVSRSMQPYAAIYLRLMRAAVLRRAGGHPEVFAFSTSLTRLT
SVLSHRSAEMALHRANARVTDRYGGTFIGRSVAALLAPPHGNALRGAVVIIASDGWDS
DPPDVLVHALTRVRRRAELLVWLNPRAAHPEFQPRAGSMAAALPYCDLFLPAHSLAGL
HQLLLALAGAR"
gene complement(446531..447046)
/locus_tag="Rv0369c"
CDS complement(446531..447046)
/codon_start=1
/transl_table=11
/locus_tag="Rv0369c"
/product="Possible membrane oxidoreductase"
/note="Rv0369c, (MTV036.04c), len: 171 aa. Possible
membrane protein oxidoreductase, similar to ORF 4 of the
Pseudomonas thermocarboxydovorans protein of
cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 ORF4 from
Pseudomonas thermocarboxydovorans (171 aa), FASTA scores:
opt: 226,E(): 9.8e-08, (31.3% identity in 166 aa overlap).
Also similar to MTV036.05, MTV036.08, MTV036.09, and
MTV026.10."
/db_xref="EnsemblGenomes-Gn:Rv0369c"
/db_xref="EnsemblGenomes-Tr:CCP43099"
/db_xref="GOA:O53704"
/db_xref="InterPro:IPR010419"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O53704"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43099.1"
/translation="MPGAQLIGHEGDEYLGKVKVKVGPVTSEFSGKVHFVEQDRNQHR
AVFDAKGKEARGTGNAAATVAAQLHEVGERTRVTVDTDLKIVGKLAQFGSGMLQQVSE
KLLGQFVDSLEAELAAQSSESPQGTPPATEAAPIDLLQLADGGQLKKYGSALLAALTV
LLLIWVLRRRR"
gene complement(447147..448043)
/locus_tag="Rv0370c"
CDS complement(447147..448043)
/codon_start=1
/transl_table=11
/locus_tag="Rv0370c"
/product="Possible oxidoreductase"
/note="Rv0370c, (MTV036.05c), len: 298 aa. Possible
oxidoreductase, similar to many hypothetical proteins, but
also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL
gene cluster from Pseudomonas/Oligotropha carboxidovorans
(295 aa), FASTA scores: opt: 851, E(): 0, (48.2% identity
in 282 aa overlap); AJ224684|BJAJ4684_3 cooxS from
Bradyrhizobium japonicum (302 aa), FASTA scores: opt:
881,E(): 0, (47.6% identity in 290 aa overlap). Also
highly similar to MTCY428_21 from Mycobacterium
tuberculosis. Contains PS00017 ATP/GTP-binding site motif
A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0370c"
/db_xref="EnsemblGenomes-Tr:CCP43100"
/db_xref="GOA:O53705"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011704"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O53705"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP43100.1"
/translation="MTFASPDDVIRRFDEQNYLLDTGTASAIYLAVTLGRPLLLEGEP
GVGKTTAAKTLAVVLDTTLIRLQCYEGLTANEALYDWNYQRQLLSIRLAEARGKGISD
ISEADLYTEAYLVDRPILRCVRHRGPTPPVLLIDEIDRADDEFEALLLEFLGESAVTV
PELGTFLAECPPIAVLTSNRSRDLHDALRRRCLYHWIDYPGPDRAAAIVRRTVPGATA
PLIENATQFVCTARDLDLDKPPGVAETIDWVAALVALGVADLTAADSSPALASLGALA
KTPDDRTQIRDAYQAFTECSHA"
gene complement(448040..448633)
/locus_tag="Rv0371c"
CDS complement(448040..448633)
/codon_start=1
/transl_table=11
/locus_tag="Rv0371c"
/product="Conserved hypothetical protein"
/note="Rv0371c, (MTV036.06c), len: 197 aa. Conserved
hypothetical protein, similar to other hypothetical
proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824
hypothetical protein from Streptomyces coelicolor (207
aa),FASTA scores: opt: 247, E(): 4.5e-09, (32.3% identity
in 195 aa overlap). Also weak similarity with
YURE|D70017|Z99120|BSUB0017_134 hypothetical protein yurE
from Bacillus subtilis (197 aa), FASTA scores: opt:
217,E(): 2.5e-08, (27.0% identity in 174 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0371c"
/db_xref="EnsemblGenomes-Tr:CCP43101"
/db_xref="InterPro:IPR025877"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:I6WY86"
/protein_id="CCP43101.1"
/translation="MTATQITGVVLAAGRSNRLGTPKQLLPYRDTTVLGATLDVARQA
GFDQLILTLGGAASAVRAAMALDGTDVVVVEDVERGCAASLRVALARVHPRATGIVLM
LGDQPQVAPATLRRIIDVGPATEIMVCRYADGVGHPFWFSRTVFGELARLHGDKGVWK
LVHSGRHPVRELAVDGCVPLDVDTWDDYRRLLESVPS"
gene complement(448630..449385)
/locus_tag="Rv0372c"
CDS complement(448630..449385)
/codon_start=1
/transl_table=11
/locus_tag="Rv0372c"
/product="Conserved hypothetical protein"
/note="Rv0372c, (MTV036.07c), len: 251 aa. Conserved
hypothetical protein, showing some similarity with
CAB76248.1|X82447|COXF CoxF protein from
Pseudomonas/Oligotropha carboxidovorans (280 aa);
AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum
(176 aa), FASTA scores: opt: 186, E(): 1.6e-05, (41.1%
identity in 95 aa overlap). Also similar to upstream ORF
Rv0376c from Mycobacterium tuberculosis (380 aa), FASTA
scores: E(): 6.8e-07, (31.0% identity in 277 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0372c"
/db_xref="EnsemblGenomes-Tr:CCP43102"
/db_xref="InterPro:IPR003777"
/db_xref="InterPro:IPR027051"
/db_xref="UniProtKB/TrEMBL:O53707"
/protein_id="CCP43102.1"
/translation="MSISDRAAQLVAARTPFVRATVVRAQQPTSARPGDEAILLADGT
IEGFVGGHCAQNSVRKAAMGVLQAGESVLLRVLPDGDVHFPEAPGACVVVNPCLAGGS
LEIFLTPQLPAPLIQIYGETPIADALIELCGLLGYDARRDTDPADTDALPTAIVIASH
GGPEAEIIRTALDNGVGYVGLVASTVRGASILDSLDLSDAERARVHTPVGLAIGAKTP
AEIAVSIAAELIATLRGGGPRGRKALADENGGA"
gene complement(449404..451803)
/locus_tag="Rv0373c"
CDS complement(449404..451803)
/codon_start=1
/transl_table=11
/locus_tag="Rv0373c"
/product="Probable carbon monoxyde dehydrogenase (large
chain)"
/note="Rv0373c, (MTV036.08c), len: 799 aa. Probable carbon
monoxide dehydrogenase, large chain, highly similar to
others e.g. AAD00363.1| U80806|CUTL carbon monoxide
dehydrogenase large subunit CutL protein from
Hydrogenophaga pseudoflava (803 aa);
S49124|509391|CAA54902.1|X77931|1094915|2107180C|CUTA
carbon-monoxide dehydrogenase large chain (cut operon)
from Pseudomonas thermocarboxydovorans (842 aa);
C56279|809566|CAA57829.1|X82447|OCCOXMSL4_3|COXL
carbon-monoxide dehydrogenase large chain (cluster coxMSL)
from Pseudomonas/Oligotropha carboxydovorans (809
aa),FASTA scores: opt: 2484, E(): 0, (56.0% identity in
804 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0373c"
/db_xref="EnsemblGenomes-Tr:CCP43103"
/db_xref="GOA:O53708"
/db_xref="InterPro:IPR000674"
/db_xref="InterPro:IPR008274"
/db_xref="InterPro:IPR012780"
/db_xref="InterPro:IPR036856"
/db_xref="InterPro:IPR037165"
/db_xref="UniProtKB/TrEMBL:O53708"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43103.1"
/translation="MTTIESRPPSPEDLADNAQQPCGHGRMMRKEDPRFIRGRGTYVD
DVALPGMLHLAILRSPYAHARIVRIDVTAAQAHPKVKAVVTGADLAAKGLAWMPTLAN
DVQAVLATDKTRFQGQEVAFVVAEDRYSARDACELVDVDYEPRDPVVDARTALDPSAP
VIRTDLEGKSDNHIFDWETGDAAATEAVFAKADVVVQQEIVYPRVHPAPMETCGAVAD
LDPVTGKLTLWTTSQAPHAHRTLYALVAGLPEHKIRVISPDIGGGFGNKVPIYPGYVC
AIVASLLLDKPVKWMEDRSENLTSTGFARDYIMVGEIAANRDGKILAIRSNVLADHGA
FNAQAAPAKYPAGFFGVFTGSYDIEAAYCHMTAVYTNKAPGGVAYACSFRITEAVYFV
ERLVDCLAFELKMDPAELRLRNLLRPNQFPYQSKTGWVYDSGDYETTMRKAMNMIGYE
ALRAEQKQRRARGELMGIGMSFFTEAVGAGPRKDMDILGLGMADGCELRVHPTGKAVL
RLSVQTQGQGHETTFAQIVAEELGIAPDDIEVVHGDTDQTPFGLGTYGSRSTPVSGGA
AALVARKVRDKAKIIASGMLEVSVADLQWEKGKFHVKGDPSAAVTIADIAMRAHGAGD
LPEGIEGGLDAEVCYNPSNLTYPYGAYFCVVDIDPGTAVVKVRRFLAVDDCGTRINPM
IIEGQVHGGIVDGIGMALMEMIAFDEDGNCLGGSLMDYLIPTALEVPHLETGHTVTPS
PHHPIGAKGIGESATVGSPPAVVNAVVDALAPFGVRHADMPLTPSRVWEAMQGRATPP
I"
gene complement(451800..452279)
/locus_tag="Rv0374c"
CDS complement(451800..452279)
/codon_start=1
/transl_table=11
/locus_tag="Rv0374c"
/product="Probable carbon monoxyde dehydrogenase (small
chain)"
/note="Rv0374c, (MTV036.09c), len: 159 aa. Probable carbon
monoxide dehydrogenase, small chain, highly similar to
others e.g. B56279|5822285|X82447|OCCOXMSL4_2|COXS
carbon-monoxide dehydrogenase small chain from
Pseudomonas/Oligotropha carboxydovorans (166 aa), FASTA
scores: opt: 662, E(): 0, (59.3% identity in 150 aa
overlap); CAA12063.1|AJ224684 putative carbon monoxide
dehydrogenase small subunit from Bradyrhizobium japonicum
(161 aa); S49123|509390|CAA54901.1|X77931|CUTC
carbon-monoxide dehydrogenase small chain from Pseudomonas
thermocarboxydovorans (163 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0374c"
/db_xref="EnsemblGenomes-Tr:CCP43104"
/db_xref="GOA:O53709"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR002888"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR036010"
/db_xref="InterPro:IPR036884"
/db_xref="UniProtKB/TrEMBL:O53709"
/protein_id="CCP43104.1"
/translation="MQVNMTVNGEPVTAEVEPRMLLVHFLRDQLRLTGTHWGCDTSNC
GTCVVEVDGVPVKSCTMLAVMASGHSIRTVEGLAGPDGQLDPVQEGFMRCHGLQCGFC
TPGMLITARALLDRNPDPDEQTIREAISGQICRCTGYTTIVRSIQWAAAHQTVKAQS"
gene complement(452294..453154)
/locus_tag="Rv0375c"
CDS complement(452294..453154)
/codon_start=1
/transl_table=11
/locus_tag="Rv0375c"
/product="Probable carbon monoxyde dehydrogenase (medium
chain)"
/note="Rv0375c, (MTV036.10c), len: 286 aa. Probable carbon
monoxide dehydrogenase, medium chain, similar to others
e.g. AAD00361.1|U80806|CUTM carbon monoxide dehydrogenase
middle subunit from Hydrogenophaga pseudoflava (287 aa);
S49122|509389|CAA54900.1|X77931|CUTB carbon-monoxide
dehydrogenase medium chain from Pseudomonas
thermocarboxydovorans (287 aa);
A56279|809564|CAA57827.1|X82447|OCCOXMSL4_1|COXM|CODH
carbon-monoxide dehydrogenase medium chain from
Pseudomonas/Oligotropha carboxydovorans (288 aa), FASTA
scores: opt: 594, E(): 0, (37.5% identity in 277 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0375c"
/db_xref="EnsemblGenomes-Tr:CCP43105"
/db_xref="GOA:I6Y7N2"
/db_xref="InterPro:IPR002346"
/db_xref="InterPro:IPR005107"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016167"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="InterPro:IPR036683"
/db_xref="UniProtKB/TrEMBL:I6Y7N2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43105.1"
/translation="MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPEYLVDINDL
APELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIFRDAERVIADPVVRNRG
TLGGSLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIAIDDFLVGPYETALAHNEVLI
EVRIPLRHNTSSAYAKVERRVGDWAITAAGAAVTLDGQTILAARVGLTAVNPDPVALA
ELSAGLVGQPATEEVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGR
VLGAPAAPEA"
gene complement(453230..454372)
/locus_tag="Rv0376c"
CDS complement(453230..454372)
/codon_start=1
/transl_table=11
/locus_tag="Rv0376c"
/product="Conserved hypothetical protein"
/note="Rv0376c, (MTV036.11c), len: 380 aa. Conserved
hypothetical protein, highly similar to
T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical
protein from Streptomyces coelicolor (395 aa); and
AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from
Arthrobacter nicotinovorans (377 aa). And similar to other
conserved hypothetical proteins e.g.
NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical
protein from Mesorhizobium loti (245 aa). Note that
C-terminus shows similarity with C-termini of
CAB76248.1|X82447|COXF CoxF protein from
Pseudomonas/Oligotropha carboxidovorans (280 aa);
CAB76250.1|X82447|COXI CoxI protein from
Pseudomonas/Oligotropha carboxidovorans (330 aa); and
AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum
(176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in
138 aa overlap). Also some partial similarity with
AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum
(107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3%
identity in 92 aa overlap); E1184330|Z99120|YURF YURF
protein from Bacillus subtilis (330 aa), FASTA scores:
opt: 170, E(): 2.9e- 16, (27.5% identity in 345 aa
overlap). Also similar to downstream ORF Rv0372c from
Mycobacterium tuberculosis (251 aa), FASTA scores: E():
2.1e-06, (30.7% identity in 277 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0376c"
/db_xref="EnsemblGenomes-Tr:CCP43106"
/db_xref="InterPro:IPR003777"
/db_xref="InterPro:IPR027051"
/db_xref="UniProtKB/TrEMBL:O53711"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43106.1"
/translation="MAIWAAGDTAGVATVVRTLRSAPRPPGAAMVVAPDGSVSGSVSG
GCVEGAVYELAAEVAQTGIPRLEHYGVSDDTAFAVGLTCGGIIDVFVEPVSRATFPEL
GELADDIGAQRPVAIATVIAHPDERRVGRRLVIRPDTKSPVTGSLGSARADAAVIDDA
RGLLAVGRSEILEYGPDGQRRGEGMEVFVSSHAPRPRMLVFGAIDFAAALARQGSFLG
YRVTVCDARAVFATPARFPTADDVVVAWPHRYLAAQAEAGGIDERTVICVLTHDPKFD
VPVLEVALRLGVGYVGAMGSRKTHDDRMDRLRAAGLTDAELSRLSSPIGLDLGARTPE
ETAVSIAADIIARRWGGGGRPLADIAGRIHHDAQVAGEFKDYLTRH"
gene 454421..455386
/locus_tag="Rv0377"
CDS 454421..455386
/codon_start=1
/transl_table=11
/locus_tag="Rv0377"
/product="Probable transcriptional regulatory protein
(probably LysR-family)"
/note="Rv0377, (MTV036.12), len: 321 aa. Probable
transcription regulator, lysR family, showing similarity
with many hypothetical transcriptional regulators lysR
homolog e.g. P32484|YEIE_ECOLI|M89774 hypothetical
transcriptional regulator from Escherichia coli (293
aa),FASTA scores: opt: 265, E(): 4.9e-11, (28.6% identity
in 266 aa overlap). Also similar to Rv2282c from
Mycobacterium tuberculosis. Contains PS00044 bacterial
regulatory protein lysR family signature. Seems to belong
to the LysR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv0377"
/db_xref="EnsemblGenomes-Tr:CCP43107"
/db_xref="GOA:P9WMF7"
/db_xref="InterPro:IPR000847"
/db_xref="InterPro:IPR005119"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMF7"
/inference="protein motif:PROSITE:PS00044"
/protein_id="CCP43107.1"
/translation="MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMHVAALRKELD
DPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTAIEVTEAAHGRRLLRIAASSAFAE
HAAPGLIELFSSRADDLSVELSVHPTSRFRELICSRAVDIAIGPASESSIGSDGSIFL
RPFLKYQIITVVAPNSPLAAGIPMPALLRHQQWMLGPSAGSVDGEIATMLRGLAIPES
QQRIFQSDAAALEEVMRVGGATLAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLA
PSARQPAVSELVGFISTPRCIQAMIPGSGVGVTRFRPKVHVTLWS"
gene 455637..455858
/locus_tag="Rv0378"
CDS 455637..455858
/codon_start=1
/transl_table=11
/locus_tag="Rv0378"
/product="Conserved hypothetical glycine rich protein"
/note="Rv0378, (MTV036.13), len: 73 aa. Conserved
hypothetical gly-rich protein, showing some similarity to
Mycobacterium tuberculosis PE_PGRS family; also similar to
MTCY06H11_16|Z85982 hypothetical glycine-rich 88.5 KD
protein (1011 aa), FASTA scores: opt: 237, E():
0.0032,(58.7% identity in 63 aa overlap); MTV043_25."
/db_xref="EnsemblGenomes-Gn:Rv0378"
/db_xref="EnsemblGenomes-Tr:CCP43108"
/db_xref="UniProtKB/TrEMBL:O53713"
/protein_id="CCP43108.1"
/translation="MSGRWEAGNADGNGGSAGLIGSGGAGGDGGSGGATGAGGEGGDA
GASGSINGNAGDPGNSGERGAVGKPGAPG"
gene 455977..456192
/gene="secE2"
/locus_tag="Rv0379"
CDS 455977..456192
/codon_start=1
/transl_table=11
/gene="secE2"
/locus_tag="Rv0379"
/product="Possible protein transport protein SecE2"
/note="Rv0379, (MTV036.14), len: 71 aa. Possible
secE2,protein transport protein, showing similarity with
P27340|S61G_SULSO|SECE preprotein translocase SECE subunit
(protein transport protein SEC61 gamma subunit homolog)
from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt:
79, E(): 4.7. (30.3% identity in 66 aa overlap); and
hypothetical proteins e.g. Q9HPW4|VNG1446H hypothetical
protein from Halobacterium sp. strain NRC-1 (77 aa);
Q9I794|PA0038 hypothetical protein from Pseudomonas
aeruginosa (71 aa); etc. Also highly similar to
U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis
protein from a patient isolate (116 aa), FASTA scores:
opt: 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap).
Note that for Rv0379|MTV036.14, a translation initiation
region different to the one in U85467|MTU85467_1 was
chosen. Could be a part of the prokaryotic protein
translocation apparatus which comprise SECA|Rv3240c,
SECD|Rv2587c,SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 and
SECY|Rv0732."
/db_xref="EnsemblGenomes-Gn:Rv0379"
/db_xref="EnsemblGenomes-Tr:CCP43109"
/db_xref="GOA:Q6MX43"
/db_xref="InterPro:IPR009923"
/db_xref="InterPro:IPR025543"
/db_xref="InterPro:IPR036694"
/db_xref="PDB:3ONR"
/db_xref="UniProtKB/Swiss-Prot:Q6MX43"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43109.1"
/translation="MSVYKVIDIIGTSPTSWEQAAAEAVQRARDSVDDIRVARVIEQD
MAVDSAGKITYRIKLEVSFKMRPAQPR"
gene complement(456268..456819)
/locus_tag="Rv0380c"
CDS complement(456268..456819)
/codon_start=1
/transl_table=11
/locus_tag="Rv0380c"
/product="Possible RNA methyltransferase (RNA methylase)"
/note="Rv0380c, (MTV036.15c), len: 183 aa. Possible RNA
methyltransferase, equivalent to CAC32002.1|AL583925
possible RNA methyltransferase from Mycobacterium leprae
(182 aa). Also some similarity with others
methyltransferases e.g. P19396|TRMH_ECOLI|78514|JV0043
tRNA (guanosine-2'-O-)-methyltransferase (tRNA
methyltransferase) from Escherichia coli (229 aa), FASTA
scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa
overlap). Also similar to Rv0881, Rv3579c, Rv1644 from
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0380c"
/db_xref="EnsemblGenomes-Tr:CCP43110"
/db_xref="GOA:O53715"
/db_xref="InterPro:IPR001537"
/db_xref="InterPro:IPR029026"
/db_xref="InterPro:IPR029028"
/db_xref="UniProtKB/TrEMBL:O53715"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43110.1"
/translation="MLLRDGDARNVVDAYRYWTREAIIADIDTRRHPLHVAIENFGHD
ANIGSVVRTANAFAVHTVHIVGRRRWNRRGAMVTDRYQRLCHHDSTTGLLEFAAGAGL
TVVAVDNVPGAARLEQTALPRECLLLFGQEGPGITDDARAGAAVTVSIAQFGSTRSIN
AGVAAGIAMHAWIRQHADLGRAW"
gene complement(456915..457823)
/locus_tag="Rv0381c"
CDS complement(456915..457823)
/codon_start=1
/transl_table=11
/locus_tag="Rv0381c"
/product="Hypothetical protein"
/note="Rv0381c, (MTV036.16c), len: 302 aa. Hypothetical
unknown protein. Equivalent to AAK44616.1 from
Mycobacterium tuberculosis strain CDC1551 (254 aa) but
longer 48 aa."
/db_xref="EnsemblGenomes-Gn:Rv0381c"
/db_xref="EnsemblGenomes-Tr:CCP43111"
/db_xref="GOA:O53716"
/db_xref="UniProtKB/TrEMBL:O53716"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43111.1"
/translation="MRILVAWATCGAVVLSGLTGCSGSSHSGRTYGAQSARTGESLAV
LGWNMSVSNLRWSGDYVLIDVDASPTDPHAPHAKPEDIRFGLYGALAHPMESAALGSC
GDAMAHVRDVVSPLSAPAGRLTGTVCLGPLKERSAVRGVYTYSPRDRIPGTAAAYPAA
FPVGMLPTNQNDAGLVVKTTSVSAWRADGMQLGKPQLGDPVAFTGNGYMLLGLEVDAV
PDRYRDDSAARGGPMMLLAAPTLPGRGLSPACATYGSSVLILPDALLDAVHISASLCT
QGEINEALLYATVATVGTHAALWTSR"
gene complement(457841..458380)
/gene="pyrE"
/gene_synonym="umpA"
/locus_tag="Rv0382c"
CDS complement(457841..458380)
/codon_start=1
/transl_table=11
/gene="pyrE"
/gene_synonym="umpA"
/locus_tag="Rv0382c"
/product="Probable orotate phosphoribosyltransferase PyrE
(OPRT) (oprtase)"
/note="Rv0382c, (MTV036.17c), len: 179 aa. Probable
pyrE,orotate phosphoribosyltransferase, equivalent to
CAC32004.1|AL583925 probable purine/pyrimidine
phosphoribosyltransferase from Mycobacterium leprae (179
aa). Also highly similar to many others e.g.
T36540|4753874|CAB42037.1|AL049754|SCH10.28c probable
orotate phosphoribosyltransferase from Streptomyces
coelicolor (182 aa);
H69115|2622996|AAB86326.1|AE000938_10|MTH1860 probable
orotate phosphoribosyltransferase from Methanobacterium
thermoautotrophicum (180 aa), FASTA scores: opt: 389, E():
2.7e-20, (40.7% identity in 172 aa overlap);
O08359|PYRE_SULAC|2065444|CAA73352.1|Y12822 orotate
phosphoribosyltransferase from Sulfolobus acidocaldarius
(197 aa); etc. Note that also similar to other puridine
5'-monophosphate synthases (umpA genes; UMP
synthases),generally in N-terminus that corresponds to
orotate phosphoribosyltransferase activity. Contains
PS00589 PTS HPR component serine phosphorylation site
signature. Belongs to the purine/pyrimidine
phosphoribosyltransferase family. Note that previously
known as umpA. Nucleotide position 458282 in the genome
sequence has been corrected,A:G resulting in Y33Y."
/db_xref="EnsemblGenomes-Gn:Rv0382c"
/db_xref="EnsemblGenomes-Tr:CCP43112"
/db_xref="GOA:P9WHK9"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR004467"
/db_xref="InterPro:IPR023031"
/db_xref="InterPro:IPR029057"
/db_xref="PDB:5HKF"
/db_xref="PDB:5HKI"
/db_xref="PDB:5HKL"
/db_xref="UniProtKB/Swiss-Prot:P9WHK9"
/inference="protein motif:PROSITE:PS00589"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43112.1"
/translation="MAGPDRAELAELVRRLSVVHGRVTLSSGREADYYVDLRRATLHH
RASALIGRLMRELTADWDYSVVGGLTLGADPVATAIMHAPGRPIDAFVVRKSAKAHGM
QRLIEGSEVTGQRVLVVEDTSTTGNSALTAVHAVQDVGGEVVGVATVVDRATGAAEAI
EAEGLRYRSVLGLADLGLD"
gene complement(458461..459315)
/locus_tag="Rv0383c"
CDS complement(458461..459315)
/codon_start=1
/transl_table=11
/locus_tag="Rv0383c"
/product="Possible conserved secreted protein"
/note="Rv0383c, (MTV036.18c), len: 284 aa. Possible
conserved secreted protein, with hydrophobic stretch in
N-terminus and Pro-rich C-terminus. Equivalent to
CAC32006.1|AL583925 possible secreted protein from
Mycobacterium leprae (286 aa). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0383c"
/db_xref="EnsemblGenomes-Tr:CCP43113"
/db_xref="GOA:O53718"
/db_xref="UniProtKB/TrEMBL:O53718"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43113.1"
/translation="MVPLWFTLSALCFVGAVVLLYVDIDRRRGRSRRRKSWARSHGFD
YERESTEILKRWTRGVMSTVGDVAAHNVVLGQIRGEAVYIFDLEEVATVIALHRKVGT
NVVVDLRLKGLKEPRESDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAE
IMWNEQNWTLVSMPIASTRAQWDEGLRTVRQFNDLLRVLPPLPQEMPQQTGVGPRGAA
PGRPVAPGGPAELPPRRAQPDPATTVLPDPARRAPEPIRRDEGRSEGVRRPPPAGRNG
QQATNYQH"
gene complement(459456..462002)
/gene="clpB"
/gene_synonym="htpM"
/locus_tag="Rv0384c"
CDS complement(459456..462002)
/codon_start=1
/transl_table=11
/gene="clpB"
/gene_synonym="htpM"
/locus_tag="Rv0384c"
/product="Probable endopeptidase ATP binding protein
(chain B) ClpB (ClpB protein) (heat shock protein F84.1)"
/note="Rv0384c, (MTV036.19c), len: 848 aa. Probable clpB
(alternate gene name: htpM), endopeptidase ATP-binding
protein, chain B, equivalent to AC32007.1|AL583925 heat
shock protein from Mycobacterium leprae (848 aa). Also
highly similar to others e.g.
P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1
CLPB protein (heat-inducible expression) from
Corynebacterium glutamicum (852 aa), FASTA scores: opt:
4113, E(): 0,(74.5% identity in 846 aa overlap);
T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c
probable ATP-dependent proteinase ATP-binding chain from
Streptomyces coelicolor (853 aa);
P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB protein
(heat shock protein F84.1) from Escherichia coli strains
K12 and O157:H7 (857 aa); etc. Also similar to
Rv3596c|ClpC from Mycobacterium tuberculosis. Contains
PS00870 and PS00871 Chaperonins clpA/B signatures and two
PS000017 ATP/GTP-binding site motives a (P-loop). Belongs
to the CLPA/CLPB family. Contains probable coiled-coil
domain from aa 411-503. Conserved in M. tuberculosis, M.
leprae, M. bovis and M. avium paratuberculosis; predicted
to be essential for in vivo survival and pathogenicity
(See Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0384c"
/db_xref="EnsemblGenomes-Tr:CCP43114"
/db_xref="GOA:P9WPD1"
/db_xref="InterPro:IPR001270"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR004176"
/db_xref="InterPro:IPR017730"
/db_xref="InterPro:IPR018368"
/db_xref="InterPro:IPR019489"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR028299"
/db_xref="InterPro:IPR036628"
/db_xref="InterPro:IPR041546"
/db_xref="PDB:6DJU"
/db_xref="PDB:6DJV"
/db_xref="PDB:6ED3"
/db_xref="UniProtKB/Swiss-Prot:P9WPD1"
/inference="protein motif:PROSITE:PS00871"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00870"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43114.1"
/translation="MDSFNPTTKTQAALTAALQAASTAGNPEIRPAHLLMALLTQNDG
IAAPLLEAVGVEPATVRAETQRLLDRLPQATGASTQPQLSRESLAAITTAQQLATELD
DEYVSTEHVMVGLATGDSDVAKLLTGHGASPQALREAFVKVRGSARVTSPEPEATYQA
LQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEG
LAQRIVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEERLKAVLDDIKNSAGQIITF
IDELHTIVGAGATGEGAMDAGNMIKPMLARGELRLVGATTLDEYRKHIEKDAALERRF
QQVYVGEPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAATLSDRYITARFLPDKAI
DLVDEAASRLRMEIDSRPVEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELA
DQKEKLAELTTRWQNEKNAIEIVRDLKEQLEALRGESERAERDGDLAKAAELRYGRIP
EVEKKLDAALPQAQAREQVMLKEEVGPDDIADVVSAWTGIPAGRLLEGETAKLLRMED
ELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPTGVGKTELAKALADFL
FDDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIE
KAHPDVFDVLLQVLDEGRLTDGHGRTVDFRNTILILTSNLGSGGSAEQVLAAVRATFK
PEFINRLDDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGF
DPVYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSLILG"
gene 462135..463307
/locus_tag="Rv0385"
CDS 462135..463307
/codon_start=1
/transl_table=11
/locus_tag="Rv0385"
/product="Probable monooxygenase"
/note="Rv0385, (MTV036.20), len: 390 aa. Probable
monooxygenase, similar to
T37003|5738846|CAB52917.1|AL109949 probable
flavohemoprotein from Streptomyces coelicolor (435 aa);
and similar in part (C-termini) to various monooxygenases
e.g. P19734|DMPP_PSESP|94993|F37831 phenol hydroxylase P5
protein (phenol 2-monooxygenase P5 component) from
Pseudomonas putida (353 aa), FASTA scores: opt: 363, E():
4.2e-16, (31.8% identity in 255 aa overlap);
S47292|2120861|pir|S70085 phenol 2-monooxygenase chain
mopP from Acinetobacter calcoaceticus (350 aa);
P21394|XYLA_PSEPU|94933|B37316 xylene monooxygenase
electron transfer component [includes: ferredoxin;
ferredoxin--NAD(+) reductase] from Pseudomonas putida
plasmid pWW0 (350 aa); AAC38360.1|AF043544|NtnMA|ntnA
reductase component of 4-nitrotoluene monooxygenase from
Pseudomonas sp. (328 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0385"
/db_xref="EnsemblGenomes-Tr:CCP43115"
/db_xref="GOA:Q7ARS9"
/db_xref="InterPro:IPR000971"
/db_xref="InterPro:IPR001433"
/db_xref="InterPro:IPR001709"
/db_xref="InterPro:IPR008333"
/db_xref="InterPro:IPR009050"
/db_xref="InterPro:IPR012292"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR039261"
/db_xref="UniProtKB/TrEMBL:Q7ARS9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43115.1"
/translation="MGLEDRDALRVLQNAFKLDDPELVRRFYAHWFALDASVRDLFPP
DMGAQRAAFGQALHWVYGELVAQRAEEPVAFLAQLGRDHRKYGVLPTQYDTLRRALYT
TLRDYLGHPSRGAWTDAVDEAAGQSLNLIIGVMSGAADADDAPAWWDGTVVEHIRVSR
DLAVARLQLDRPLHYYPGQYVNVHVPQCPRRWRYLSPAIPADPNGRIEFHVRVVPGGL
VSNAIVGETRPGDRWRLSGPHGAFRVDRDGGDVLMVAGSTGLAPLRALIIDLSRFAVN
PRVHLFFGARYACELYDLPTLWQIAAHNPWLSVSPVSEYNGDPAWAADYPDVSAPRGL
HVRQTGRLPDVVSRYGGWGDRQILICGGPAMVRATKAALIAKGAPPERIQHDPLSR"
gene 463411..466668
/locus_tag="Rv0386"
CDS 463411..466668
/codon_start=1
/transl_table=11
/locus_tag="Rv0386"
/product="Probable transcriptional regulatory protein
(probably LuxR/UhpA-family)"
/note="Rv0386, (MTV036.21), len: 1085 aa. Probable
regulatory protein, LuxR/uhpA family, highly similar to
CAC30706.1|AL583923 possible transcriptional regulator
from Mycobacterium leprae (1106 aa). Also similar in part
to other regulatory proteins e.g. CAB95788.1|AL359949
putative multi-domain regulatory protein from Streptomyces
coelicolor (780 aa); N-terminus of CAB92369.1|AL356612
putative AfsR-like regulatory protein from Streptomyces
coelicolor (1114 aa); N-terminus of
NP_107139.1|14026327|BAB52925.1|AP003009 transcriptional
regulator from Mesorhizobium loti (952 aa);
AFSR_STRCO|P25941 regulatory protein afsr from
Streptomyces coelicolor (993 aa), FASTA scores: opt: 224,
E() : 1.1e-06,(26.1% identity in 867 aa overlap); etc.
Also similar to many putative Mycobacterium tuberculosis
regulatory proteins e.g. AL0212|MTV008_44 (1137 aa), FASTA
scores: opt: 3756, E(): 0, (56.7% identity in 1089 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop),PS00622 Bacterial regulatory proteins, luxR
family signature and probable helix-turn-helix motif at aa
1042-1063 (Score 1025, +2.68 S D). Belongs to the
LuxR/UhpA family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv0386"
/db_xref="EnsemblGenomes-Tr:CCP43116"
/db_xref="GOA:O53720"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR002182"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:O53720"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00622"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43116.1"
/translation="MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSG
VIAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALR
DEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSR
PERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVT
LTGAGGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRS
TTDTVLRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEV
SYRVPSLSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAAR
LRSMTLDEIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAV
FVGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYA
LEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNR
ENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADK
ALLDIFVDAAAGMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAE
AIDLARAVDDRWRLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCR
WCLGYAQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARA
AADAALEAAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQ
RAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAH
KALACAAESGAHLDLPDVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYR
SDYVQSVTALRDAMGEKDFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPT
EIDVVRLVGEGLANKDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT"
gene complement(466672..467406)
/locus_tag="Rv0387c"
CDS complement(466672..467406)
/codon_start=1
/transl_table=11
/locus_tag="Rv0387c"
/product="Conserved hypothetical protein"
/note="Rv0387c, (MTV036.22c), len: 244 aa. Conserved
hypothetical protein, showing some similarity to
MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon
1, Elastin (687 aa), FASTA scores: opt: 193, E():
0.35,(34.4% identity in 189 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0387c"
/db_xref="EnsemblGenomes-Tr:CCP43117"
/db_xref="InterPro:IPR022171"
/db_xref="UniProtKB/TrEMBL:L0T6I4"
/protein_id="CCP43117.1"
/translation="MSLLPTLQSFLPPPFDAIPNPIEDLDVLVAAAVAVAAGSLGVSA
AQLGEIYRHDVVDEAQKAPHCPAESDQTPAGAAGDGDLPEVGGRVTSPPQPPVAALTG
YSANIGGLSVPHSWNLPPAVRQVAAMFPGATPMYMTGSSDGSYAGLAAAGLAGTGLAG
LAARGGSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAAAAGSAIPGLPPGLPPGVV
ANLAATLAAIPGATIIVVPPSPNANQ"
gene complement(467459..468001)
/gene="PPE9"
/locus_tag="Rv0388c"
CDS complement(467459..468001)
/codon_start=1
/transl_table=11
/gene="PPE9"
/locus_tag="Rv0388c"
/product="PPE family protein PPE9"
/note="Rv0388c, (MTV036.23c), len: 180 aa. PPE9, Member of
the Mycobacterium tuberculosis PPE family, highly similar
to others e.g. MTCY10G2_10|Z92539 from Mycobacterium
tuberculosis (391 aa), FASTA scores: opt: 667, E():
0,(58.3% identity in 180 aa overlap) but much shorter."
/db_xref="EnsemblGenomes-Gn:Rv0388c"
/db_xref="EnsemblGenomes-Tr:CCP43118"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:L0T6B3"
/protein_id="CCP43118.1"
/translation="MDFGALPPEINSARIYSGPGSRPLMQAAAAWQRLANELTATAAS
YSSVISGLTGDDWLGPSALSMAAAAVPYVAWMRATAASAEQAAAQAVAAANAYESAYA
ATVPPTVIAANRRTMLSLVQTNVFGQNTPAIATSETHYGEMWAHDILAMDGYAGASGA
ASQLRRSPATGDHQRGRVAE"
gene 468335..469594
/gene="purT"
/locus_tag="Rv0389"
CDS 468335..469594
/codon_start=1
/transl_table=11
/gene="purT"
/locus_tag="Rv0389"
/product="Probable phosphoribosylglycinamide
formyltransferase 2 PurT (GART 2) (gar transformylase 2)
(5'-phosphoribosylglycinamide transformylase 2)
(formate-dependent gar transformylase)"
/note="Rv0389, (MTCY04D9.01, MTV036.24), len: 419 aa.
Probable purT, phosphoribosylglycinamide formyltransferase
2, similar to others e.g. P33221|PURT_ECOLI|B1849
phosphoribosylglycinamide formyltransferase 2 from
Escherichia coli strain K-12 (391 aa), FASTA scores: opt:
481, E(): 1.3e-22, (40.1% identity in 379 aa overlap);
etc. Belongs to the PurK / PurT family. Cofactor:
magnesium."
/db_xref="EnsemblGenomes-Gn:Rv0389"
/db_xref="EnsemblGenomes-Tr:CCP43119"
/db_xref="GOA:P95197"
/db_xref="InterPro:IPR003135"
/db_xref="InterPro:IPR005862"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR013815"
/db_xref="InterPro:IPR016185"
/db_xref="UniProtKB/TrEMBL:P95197"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43119.1"
/translation="MIDGWTEEQHEPTVRHERPAAPQDVRRVMLLGSAEPSRELAIAL
QGLGAEVIAVDGYVGAPAHRIADQSVVVTMTDAEELTAVIRRLQPDFLVTVTAAVSVD
ALDAVEQADGECTELVPNARAVRCTADREGLRRLAADQLGLPTAPFWFVGSLGELQAV
AVHAGFPLLVSPVAGVAGQGSSVVAGPNEVEPAWQRAAGHQVQPQTGGVSPRVCAESV
VEIEFLVTMIVVCSQGPNGPLIEFCAPIGHRDADAGELESWQPQKLSTAALDAAKSIA
ARIVKALGGRGVFGVELMINGDEVYFADVTVCPAGSAWVTVRSQRLSVFELQARAILG
LAVDTLMISPGAARVINPDHTAGRAAVGAAPPADALTGALGVPESDVVIFGRGLGVAL
ATAPEVAIARERAREVASRLNVPDSRE"
gene 469591..470013
/locus_tag="Rv0390"
CDS 469591..470013
/codon_start=1
/transl_table=11
/locus_tag="Rv0390"
/product="Conserved protein"
/note="Rv0390, (MTCY04D9.02), len: 140 aa. Conserved
protein, equivalent to
AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein
from Mycobacterium leprae (147 aa), FASTA scores: opt:
778,E(): 0, (79.0% identity in 138 aa overlap). Also
similar to hypothetical proteins from several Rickettsia
species."
/db_xref="EnsemblGenomes-Gn:Rv0390"
/db_xref="EnsemblGenomes-Tr:CCP43120"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR036873"
/db_xref="PDB:2FSX"
/db_xref="UniProtKB/TrEMBL:P95198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43120.1"
/translation="MSYAGDITPLQAWEMLSDNPRAVLVDVRCEAEWRFVGVPDLSSL
GREVVYVEWATSDGTHNDNFLAELRDRIPADADQHERPVIFLCRSGNRSIGAAEVATE
AGITPAYNVLDGFEGHLDAEGHRGATGWRAVGLPWRQG"
gene 470010..471230
/gene="metZ"
/locus_tag="Rv0391"
CDS 470010..471230
/codon_start=1
/transl_table=11
/gene="metZ"
/locus_tag="Rv0391"
/product="Probable O-succinylhomoserine sulfhydrylase MetZ
(OSH sulfhydrylase)"
/note="Rv0391, (MTCY04D9.03), len: 406 aa. Probable
metZ,O-succinylhomoserine sulfhydrylase, equivalent, but
shorter 20 aa in N-terminus, to AA18941.1|AL023514
O-succinylhomoserine sulfhydrylase from Mycobacterium
leprae (426 aa). Also highly similar to others e.g.
METZ_PSEAE|P55218 o-succinylhomoserine sulfhydrylase from
Pseudomonas aeruginosa (403 aa), FASTA scores: opt:
1175,E(): 0, (47.2% identity in 392 aa overlap); etc.
Belongs to the trans-sulfuration enzymes family. Could
also be a cystathionine gamma-synthase."
/db_xref="EnsemblGenomes-Gn:Rv0391"
/db_xref="EnsemblGenomes-Tr:CCP43121"
/db_xref="GOA:P9WGB5"
/db_xref="InterPro:IPR000277"
/db_xref="InterPro:IPR006234"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="PDB:3NDN"
/db_xref="UniProtKB/Swiss-Prot:P9WGB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43121.1"
/translation="MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTS
GYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVF
TSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQ
AVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGT
KHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHS
NASAQRIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQ
RAFEVLDKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLE
DTDDLIADIDRALS"
gene complement(471227..472639)
/gene="ndhA"
/locus_tag="Rv0392c"
CDS complement(471227..472639)
/codon_start=1
/transl_table=11
/gene="ndhA"
/locus_tag="Rv0392c"
/product="Probable membrane NADH dehydrogenase NdhA"
/note="Rv0392c, (MTCY04D9.04c), len: 470 aa. Probable
ndhA,membrane NADH dehydrogenase, equivalent to many e.g.
AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium
smegmatis (457 aa), FASTA scores: opt: 1991, E(): 0,
(67.9% identity in 458 aa overlap); MLCB1788_3 NADH
dehydrogenase from Mycobacterium leprae (466 aa), FASTA
score: (62.5% identity in 467 aa overlap). Also similar to
others from several organisms e.g.
P00393|DHNA_ECOLI|66211|581140|CAA23586.1|V00306 NADH
dehydrogenase from Escherichia coli (434 aa); and
Rv0392c|ndhB from Mycobacterium tuberculosis. Has
hydrophobic stretch in C-terminus. Belongs to the NADH
dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv0392c"
/db_xref="EnsemblGenomes-Tr:CCP43122"
/db_xref="GOA:P95200"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:P95200"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43122.1"
/translation="MTLSSGEPSAVGGRHRVVIIGSGFGGLNAAKALKRADVDITLIS
KTTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGEVNAIDLKAQTVTSK
LMDMTTVTPYDSLIVAAGAQQSYFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEV
STDHAERERRLTFVVVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAP
AVLPPMGPKLGLKAQRRLEKMDVEVQLNAMVTAVDYKGITIKEKDGGERRIECACKVW
AAGVAASPLGKMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVGDLMFVPGVPGVA
QGAIQGARYATTVIKHMVKGNDDPANRKPFHYFNKGSMATISRHSAVAQVGKLEFAGY
FAWLAWLVLHLVYLVGYRNRIAALFAWGISFMGRARGQMAITSQMIYARLVMTLMEQQ
AQGALAAAEQAEHAEQEAAG"
gene 472781..474106
/locus_tag="Rv0393"
CDS 472781..474106
/codon_start=1
/transl_table=11
/locus_tag="Rv0393"
/product="Conserved 13E12 repeat family protein"
/note="Rv0393, (MTCY04D9.05), len: 441 aa. Member of
Mycobacterium tuberculosis 13E12 repeat family of
conserved proteins, similar to many e.g. Rv1148c, Rv1945,
Rv3467,Rv0336|MTCY279_3 (503 aa), FASTA scores: E(): 0,
(61.1% identity in 347 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0393"
/db_xref="EnsemblGenomes-Tr:CCP43123"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:P95201"
/protein_id="CCP43123.1"
/translation="MAVGRCAIPRFDQAASGSAINGGQVHLSDGSTSPARQLPAPWPG
DAGAAAEGRAGVCCRGNRLPHVSDVGVSHRFDHRPAGVGAGGCRAGAAGAGLAVDDPG
QLAAAIDRIVAVADPDAVRQVRERARDREVSIWNSADGMGEVYAQLYATDAQALDARL
NALVATVCAGDPRSTDQRRADALGALAAGADRLACRCDNPDCAAEGRPVSAVVIHVVA
EQASVKGHGQAPAALLGGDGLIPAELVAELAKTAGLQPIPVPAGTEPGYRPSVKLAAF
VRARDLTCRAPGCDRPATQCDLDHTIAFADGGATHAANLKCLCRLHHLLATFCGWRAQ
QLPDGTVIWTLPGNQTYVTTPGSALLFPALCTPTGDPPAPEPARADRRGQRTAMMPRR
ASTRTQNRAHCIAAERHRNHQARRIAQAAVIATETHGPPPDPDDDPPPF"
gene complement(474122..474841)
/locus_tag="Rv0394c"
CDS complement(474122..474841)
/codon_start=1
/transl_table=11
/locus_tag="Rv0394c"
/product="Possible secreted protein"
/note="Rv0394c, (MTCY04D9.06c), len: 239 aa. Possible
secreted protein, sharing no homology with other proteins.
Has hydrophobic stretch at its N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0394c"
/db_xref="EnsemblGenomes-Tr:CCP43124"
/db_xref="GOA:P95202"
/db_xref="UniProtKB/TrEMBL:P95202"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43124.1"
/translation="MTEPRPVFAVVISAGLSAIPMVGGPLQTVFDAIEERTRHRAETT
TREICESVGGADTVLSRIDKNPELEPLLSQAIEAATRTSMEAKRRLLAQAAAAALEDD
QKVEPASLIVATLSQLEPVHIHALVRLAKAAKSSPDQDEIQRREVMRAASKVEPVPVL
AALIQTGVAIATTTVWHGNGTGTPAEESGHILIHDVSDFGHRLLAYLRAADAGAELLI
LPSGGSAPTGDHPTPHPSTSR"
gene 474940..475344
/locus_tag="Rv0395"
CDS 474940..475344
/codon_start=1
/transl_table=11
/locus_tag="Rv0395"
/product="Hypothetical protein"
/note="Rv0395, (MTCY04D9.07), len: 134 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0395"
/db_xref="EnsemblGenomes-Tr:CCP43125"
/db_xref="UniProtKB/TrEMBL:P95203"
/protein_id="CCP43125.1"
/translation="MDWMPLGDYETFRHWSGKPRAWGPQESGWRAWFGGKIVDGLCEV
LDEHLAVRRRGVPAAIGCVPWLSSEAVAETLLALSVFCVVIDKGTSFPSRLRNPDKGF
PNVALLRLRDMAPSEHGSRCSSARGRLCLSMS"
gene 475350..475742
/locus_tag="Rv0396"
CDS 475350..475742
/codon_start=1
/transl_table=11
/locus_tag="Rv0396"
/product="Hypothetical protein"
/note="Rv0396, (MTCY04D9.08), len: 130 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0396"
/db_xref="EnsemblGenomes-Tr:CCP43126"
/db_xref="UniProtKB/TrEMBL:P95204"
/protein_id="CCP43126.1"
/translation="MRALGWLREDRKPLLNAKLLVLGHLALNVYDPDNGYGEEVLDFE
PRTVWWGSANWTVRAGSHLEVGFACDDPTLVEEATAFVADVIAFSEPIDTTCAGPEPN
LVQVEFDDAAMAEAMEEMAEPDDDGEDW"
gene 475816..476184
/locus_tag="Rv0397"
CDS 475816..476184
/codon_start=1
/transl_table=11
/locus_tag="Rv0397"
/product="Conserved 13E12 repeat family protein"
/note="Rv0397, (MTCY04D9.09), len: 122 aa. Part of 13E12
repeat family of conserved Mycobacterium tuberculosis
proteins, similar to downstream Rv0393|Z84725|MTCY4D9_5
conserved 13E12 repeat family protein (441 aa), FASTA
scores: E(): 0, (87.7% identity in 122 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0397"
/db_xref="EnsemblGenomes-Tr:CCP43127"
/db_xref="UniProtKB/TrEMBL:P95205"
/protein_id="CCP43127.1"
/translation="MLATFWGWRAQQLPDGTVIWTLPGDQTYVTTPGSALLFPALCTP
TGDPPRPDPARADRRGQRTAMMPRRASTRAQNRAHYIAAERHRNHQARRIAHVVTQTA
TTAPETNGPPPDPDDDPPPF"
gene 476394..476642
/locus_tag="Rv0397A"
CDS 476394..476642
/codon_start=1
/transl_table=11
/locus_tag="Rv0397A"
/product="Conserved protein"
/note="Rv0397A, len: 82 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv0397A"
/db_xref="EnsemblGenomes-Tr:CCP43128"
/db_xref="UniProtKB/TrEMBL:I6Y3N9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43128.1"
/translation="MHALRLVGLAILTAIAPIAVLIGSSPAHADTDIGQPCSPEGAKL
WGNPGPIYCERTADGQLQWVSIPAWALCVAFCDRPGGP"
gene complement(476679..477320)
/locus_tag="Rv0398c"
CDS complement(476679..477320)
/codon_start=1
/transl_table=11
/locus_tag="Rv0398c"
/product="Possible secreted protein"
/note="Rv0398c, (MTCY04D9.10c), len: 213 aa. Possible
secreted protein, sharing no homology with other proteins.
Has potential signal sequence with hydrophobic stretch
from aa 7-25."
/db_xref="EnsemblGenomes-Gn:Rv0398c"
/db_xref="EnsemblGenomes-Tr:CCP43129"
/db_xref="GOA:P95206"
/db_xref="UniProtKB/TrEMBL:P95206"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43129.1"
/translation="MGVIARVVGVAACGLSLAVLAAAPTAGAEPTGALPPMTSSGSGP
VIGDGDAALRQRISQQLFSFGDPTVQEVDGSDAAQFITAAAAVADRDVASVFLPLQRV
LGCQQNTAGSGAGFGARAYRRTDGQWGGAMLVVAKSTVSDVDALKACVKSGWRKATAG
TPTSMCNNGWTYPPFADTRRGEEGYFVLLAGTASDFCSAPNANYRTTASSWPG"
gene complement(477327..478556)
/gene="lpqK"
/locus_tag="Rv0399c"
CDS complement(477327..478556)
/codon_start=1
/transl_table=11
/gene="lpqK"
/locus_tag="Rv0399c"
/product="Possible conserved lipoprotein LpqK"
/note="Rv0399c, (MTCY04D9.11c), len: 409 aa. Possible
lpqK,conserved lipoprotein, showing some similarity to
penicillin binding proteins and various peptidases e.g.
DAC_STRSQ|P15555 d-alanyl-d-alanine carboxypeptidase
protein (406 aa), FASTA scores: opt: 348, E():
5.6e-16,(29.2% identity in 301 aa overlap). Also similar
to other Mycobacterium tuberculosis PBPs and esterases.
Has possible N-terminal signal sequence and appropriately
positioned prokaryotic lipoprotein lipid attachment site
(PS00013)."
/db_xref="EnsemblGenomes-Gn:Rv0399c"
/db_xref="EnsemblGenomes-Tr:CCP43130"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:P95207"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43130.1"
/translation="MPVLRRLGCSVLALGLLAGCAPPRTGPASSPTNNGAKADAVIRI
VRDFMTQAHLKAVLVRVTVAGKEVVTRAVGDSMTGVPATTAMHFRNGAVAISYVATLL
LKLVDEKKLRLDDKLSRWLPDFPHADRVTLGQLAQMTSGYPDYVLGNEAFDAELYANP
FRQWTTQELLDQISSRPLLYDPGTNWNYAHTNYLLLGLALEKAAGQDMPTLLQRKVLS
PLGLTATANSDTPAIPEPALHAFTSERRAALKIPAGVPFYEESTFWNPSWTITHGAIQ
TTTIYDMEATAVGIGSGRLLSADSYKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLG
IVISGHWLLQNPMFAGYAAVEAYLPSQRVAVAVAVTYAPEAFDDQGNYRNQADILFRK
IGAEVAPNDAPPMPPGR"
gene complement(478566..479753)
/gene="fadE7"
/locus_tag="Rv0400c"
CDS complement(478566..479753)
/codon_start=1
/transl_table=11
/gene="fadE7"
/locus_tag="Rv0400c"
/product="Acyl-CoA dehydrogenase FadE7"
/note="Rv0400c, (MTCY04D9.12c), len: 395 aa. Probable
fadE7, acyl-CoA dehydrogenase, similar to many e.g.
CAC12923.1|AL445403 putative acyl CoA dehydrogenase from
Streptomyces coelicolor (397 aa); G624219 glutaryl-CoA
dehydrogenase precursor (438 aa), FASTA scores: opt:
1161,E(): 0, (48.1% identity in 391 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0400c"
/db_xref="EnsemblGenomes-Tr:CCP43131"
/db_xref="GOA:P95208"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P95208"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43131.1"
/translation="MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHV
AAWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRS
LVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARR
DGPDWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRA
SITSELVLDNVRLPADAMLPGATGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYA
RQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNN
TREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLA
AFR"
gene 479789..480160
/locus_tag="Rv0401"
CDS 479789..480160
/codon_start=1
/transl_table=11
/locus_tag="Rv0401"
/product="Probable conserved transmembrane protein"
/note="Rv0401, (MTCY04D9.14), len: 123 aa. Probable
conserved transmembrane protein, equivalent to
AL023514|MLCB4_9 putative integral membrane protein from
Mycobacterium leprae (122 aa), FASTA scores: opt: 548,
E(): 4.4e-32, (66.9% identity in 121 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0401"
/db_xref="EnsemblGenomes-Tr:CCP43132"
/db_xref="GOA:P95210"
/db_xref="InterPro:IPR021414"
/db_xref="UniProtKB/TrEMBL:P95210"
/protein_id="CCP43132.1"
/translation="MRPRRALAGLAADVVAVLVFCAVGRRSHAEGLSVTGLAATAWPF
LTGTGIGWVLARGWRRPTALAPTGVIVWLCTIVVGMVLRKVSSAGVAASFVVVASAVT
AVLLLGWRAAVALMAPHRADG"
gene complement(480355..483231)
/gene="mmpL1"
/locus_tag="Rv0402c"
CDS complement(480355..483231)
/codon_start=1
/transl_table=11
/gene="mmpL1"
/locus_tag="Rv0402c"
/product="Probable conserved transmembrane transport
protein MmpL1"
/note="Rv0402c, (MTCY04D9.15c), len: 958 aa. Probable
mmpL1, conserved transmembrane transport protein (see
Tekaia et al., 1999), member of RND superfamily, highly
similar to other Mycobacterial proteins e.g.
YV34_MYCTU|Q11171 hypothetical 106.2 kDa membrane protein
from Mycobacterium tuberculosis (968 aa), FASTA scores:
opt: 3551, E(): 0, (55.4% identity in 933aa overlap);
YV34_MYCLE|P54881 hypothetical 105.2 kDa protein from
Mycobacterium leprae (959 aa), FASTA scores: opt:
3615,E(): 0, (55.5% identity in 941 aa overlap); etc.
Highly similar to many other mycobacterial MmpL proteins
from Mycobacterium tuberculosis and Mycobacterium leprae
e.g. Rv0450c, Rv0676c, Rv0507, etc. Belongs to the MmpL
family."
/db_xref="EnsemblGenomes-Gn:Rv0402c"
/db_xref="EnsemblGenomes-Tr:CCP43133"
/db_xref="GOA:P9WJV9"
/db_xref="InterPro:IPR004707"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJV9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43133.1"
/translation="MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQS
VARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLV
TKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQR
IVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAA
LIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQE
ARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVT
VMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIG
LLALPKYQTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDM
LILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVA
DLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFW
RPLRSFTYWERHCFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLA
QLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPE
AFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQ
AASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVAL
SLGSAFGLSVLIWQHILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKT
GMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMT
PALATLLGRWFWWPRRVDRLARQPQVLGPRRTTALSAERAALLQ"
gene complement(483228..483656)
/gene="mmpS1"
/locus_tag="Rv0403c"
CDS complement(483228..483656)
/codon_start=1
/transl_table=11
/gene="mmpS1"
/locus_tag="Rv0403c"
/product="Probable conserved membrane protein MmpS1"
/note="Rv0403c, (MTCY04D9.16c), len: 142 aa. Probable
mmpS1, conserved membrane protein (see citation
below),highly similar to other Mycobacterial proteins e.g.
YV33_MYCLE|P54880 hypothetical 16.9 kDa protein from
Mycobacterium leprae (154 aa), FASTA scores: opt: 458,
E(): 1.6e-26, (46.9% identity in 143 aa overlap);
YV33_MYCTU|Q11170 hypothetical 15.9 kDa protein from
Mycobacterium tuberculosis (147 aa), FASTA scores: opt:
362, E(): 1.1e-19, (42.1% identity in 140 aa overlap);
etc. Also similar to other MmpS proteins from
Mycobacterium tuberculosis e.g. Rv0677c, Rv0451c, etc.
Belongs to the MmpS family. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0403c"
/db_xref="EnsemblGenomes-Tr:CCP43134"
/db_xref="GOA:P9WJT5"
/db_xref="InterPro:IPR008693"
/db_xref="InterPro:IPR038468"
/db_xref="UniProtKB/Swiss-Prot:P9WJT5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43134.1"
/translation="MFGVAKRFWIPMVIVIVVAVAAVTVSRLHSVFGSHQHAPDTGNL
DPIIAFYPKHVLYEVFGPPGTVASINYLDADAQPHEVVNAAVPWSFTIVTTLTAVVAN
VVARGDGASLGCRITVNEVIREERIVNAYHAHTSCLVKSA"
gene 483977..485734
/gene="fadD30"
/locus_tag="Rv0404"
CDS 483977..485734
/codon_start=1
/transl_table=11
/gene="fadD30"
/locus_tag="Rv0404"
/product="Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP
synthetase) (fatty-acid-AMP synthase)"
/note="Rv0404, (MTCY04D9.17-MTCY22G10.00), len: 585 aa.
fadD30, fatty-acid-AMP synthetase, similar to many e.g.
MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from
Mycobacterium bovis (582 aa); MASC_MYCLE|P54200 masc
protein from Mycobacterium leprae (372 aa), FASTA scores:
opt: 888, E(): 0, (44.2% identity in 342 aa overlap). Also
similar to Y06J_MYCTU|Q10976 hypothetical 67.9 kDa protein
(626 aa), FASTA scores: opt: 1463, E(): 0, (42.4% identity
in 568 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0404"
/db_xref="EnsemblGenomes-Tr:CCP43135"
/db_xref="GOA:P9WQ57"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ57"
/protein_id="CCP43135.1"
/translation="MSVISTLRDRATTTPSDEAFVFMDYDTKTGDQIDRMTWSQLYSR
VTAVSAYLISYGRHADRRRTAAISAPQGLDYVAGFLGALCAGWTPVPLPEPLGSLRDK
RTGLAVLDCAADVVLTTSQAETRVRATIATHGASVTTPVIALDTLDEPSGDNCDLDSQ
LSDWSSYLQYTSGSTANPRGVVLSMRNVTENVDQIIRNYFRHEGGAPRLPSSVVSWLP
LYHDMGLMVGLFIPLFVGCPVILTSPEAFIRKPARWMQLLAKHQAPFSAAPNFAFDLA
VAKTSEEDMAGLDLGHVNTIINGAEQVQPNTITKFLRRFRPYNLMPAAVKPSYGMAEA
VVYLATTKAGSPPTSTEFDADSLARGHAELSTFETERATRLIRYHSDDKEPLLRIVDP
DSNIELGPGRIGEIWIHGKNVSTGYHNADDALNRDKFQASIREASAGTPRSPWLRTGD
LGFIVGDEFYIVGRMKDLIIQDGVNHYPDDIETTVKEFTGGRVAAFSVSDDGVEHLVI
AAEVRTEHGPDKVTIMDFSTIKRLVVSALSKLHGLHVTDFLLVPPGALPKTTSGKISR
AACAKQYGANKLQRVATFP"
gene 485731..489939
/gene="pks6"
/locus_tag="Rv0405"
CDS 485731..489939
/codon_start=1
/transl_table=11
/gene="pks6"
/locus_tag="Rv0405"
/product="Probable membrane bound polyketide synthase
Pks6"
/note="Rv0405, (MTCY22G10.01), len: 1402 aa. Probable
pks6,membrane-bound polyketide synthase (see citation
below),highly similar to others e.g. CAC29643.1|AL583917
putative polyketide synthase from Mycobacterium leprae
(2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase
(1876 aa),FASTA scores: opt: 2303, E(): 0, (38.7% identity
in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl
synthases active site, 2 x PS00017 ATP/GTP-binding site
motif A (P-loop), and PS00012 Phosphopantetheine
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0405"
/db_xref="EnsemblGenomes-Tr:CCP43136"
/db_xref="GOA:O86335"
/db_xref="InterPro:IPR001031"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020802"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/TrEMBL:O86335"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43136.1"
/translation="MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSI
DVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGR
GSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFL
KDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVS
STDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVH
LACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEG
CGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARV
DPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGI
AGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSS
FGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGR
YVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGV
GKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGH
DQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDA
AMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAV
SAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQ
LVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQ
IVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW
LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAV
LGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYL
ITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPV
RNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDS
SDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLG
VALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI
FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMM
STSSEAIATEIHDWISGLVRGPHR"
gene complement(489887..490705)
/locus_tag="Rv0406c"
CDS complement(489887..490705)
/codon_start=1
/transl_table=11
/locus_tag="Rv0406c"
/product="Beta lactamase like protein"
/note="Rv0406c, (MTCY22G10.02c), len: 272 aa.
Beta-lactamase-like protein, equivalent to
AAD38170.1|AF152397_1 beta-lactamase-like protein from
Mycobacterium phlei (243 aa); AL023514|MLCB4_8
hypothetical protein from Mycobacterium leprae (251 aa),
FASTA scores: opt: 1284, E(): 0, (74.9% identity in 243 aa
overlap); and AAD38164.1|AF152394_2 beta-lactamase-like
protein from Mycobacterium avium (247 aa), FASTA scores:
opt: 1301, E(): 0, (74.2% identity in 244 aa overlap);
etc. Also slight similarity to others beta-lactamases and
hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349
metallo-beta-lactamase L1 precursor (beta-lactamase, type
II) (penicillinase) from Xanthomonas maltophilia (290
aa),FASTA scores: (34.4% identity in 96 aa overlap).
Recombinant protein has beta lactamase activity (See
Nampoothiri et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0406c"
/db_xref="EnsemblGenomes-Tr:CCP43137"
/db_xref="GOA:O86336"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:O86336"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43137.1"
/translation="MVATRGTRLAALALAPRLAGMAELVQITDKVHLARGHAVNWVLV
TDDTGVLLIDAGYPGDRAEVLASLNKLGYTPGDVRAIVLTHAHIDHLGSAIWFAREHS
TPVYCHAEEVGHAKREYRENASVFDVALRSWRPRVAVWGIHLLRRGGLTGDGIPTAQP
LTAEAAAGLPGQPMAIFTPGHTSGHCSYVVDGVLASGDALITGHPMLRHRGPQLLPAV
FSHSQQNSIRSLAALALLETNILAPGHGELWHGPIRKATDEALERAQKSNHVFR"
gene 490783..491793
/gene="fgd1"
/gene_synonym="fgd"
/locus_tag="Rv0407"
CDS 490783..491793
/codon_start=1
/transl_table=11
/gene="fgd1"
/gene_synonym="fgd"
/locus_tag="Rv0407"
/product="F420-dependent glucose-6-phosphate dehydrogenase
Fgd1"
/note="Rv0407, (MTCY22G10.03), len: 336 aa.
fgd1,F420-dependent glucose-6-phosphate
dehydrogenase,equivalent to others from Mycobacteria e.g.
AAD38165.1|AF152394_3 from Mycobacterium avium (336
aa),FASTA scores: opt: 2082, E(): 0, (89.9% identity in
336 aa overlap); AL023514|MLCB 4_7 from Mycobacterium
leprae (336 aa), FASTA scores: opt: 2069, E(): 0, (89.0%
identity in 336 aa overlap). Also similar to other
dehydrogenases e.g. CAA77276.1|Y18730 F420-dependent
alcohol dehydrogenase from Methanofollis liminatans (330
aa). Also similar to many proteins from Mycobacterium
tuberculosis e.g. Rv0953c,Rv0791c, etc. Note that
previously known as fgd."
/db_xref="EnsemblGenomes-Gn:Rv0407"
/db_xref="EnsemblGenomes-Tr:CCP43138"
/db_xref="GOA:P9WNE1"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019944"
/db_xref="InterPro:IPR019945"
/db_xref="InterPro:IPR036661"
/db_xref="PDB:3B4Y"
/db_xref="PDB:3C8N"
/db_xref="UniProtKB/Swiss-Prot:P9WNE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43138.1"
/translation="MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPW
RHQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRVF
LGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDRVDFDGDYYRLKGA
SIYDVPDGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYTEKLMPAVREGAAAA
DRSVDGIDKMIEIKISYDPDPELALNNTRFWAPLSLTAEQKHSIDDPIEMEKAADALP
IEQIAKRWIVASDPDEAVEKVGQYVTWGLNHLVFHAPGHDQRRFLELFQSDLAPRLRR
LG"
gene 491786..493858
/gene="pta"
/locus_tag="Rv0408"
CDS 491786..493858
/codon_start=1
/transl_table=11
/gene="pta"
/locus_tag="Rv0408"
/product="Probable phosphate acetyltransferase Pta
(phosphotransacetylase)"
/note="Rv0408, (MTCY22G10.04), len: 690 aa. Probable
pta,phosphate acetyltransferase, highly similar to others
e.g. PTA_ECOLI|P39184|11279789|JX0357|B2297 phosphate
acetyltransferase from Escherichia coli strain K12 (713
aa), FASTA scores: opt: 1303, E(): 0, (38.0% identity in
718 aa overlap); etc. Belongs to the phosphate
acetyltransferase and butyryltransferase family."
/db_xref="EnsemblGenomes-Gn:Rv0408"
/db_xref="EnsemblGenomes-Tr:CCP43139"
/db_xref="GOA:P9WHP1"
/db_xref="InterPro:IPR002505"
/db_xref="InterPro:IPR004614"
/db_xref="InterPro:IPR010766"
/db_xref="InterPro:IPR016475"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR028979"
/db_xref="InterPro:IPR042112"
/db_xref="InterPro:IPR042113"
/db_xref="UniProtKB/Swiss-Prot:P9WHP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43139.1"
/translation="MADSSAIYLAAPESQTGKSTIALGLLHRLTAMVAKVGVFRPITR
LSAERDYILELLLAHTSAGLPYERCVGVTYQQLHADRDDAIAEIVDSYHAMADECDAV
VVVGSDYTDVTSPTELSVNGRIAVNLGAPVLLTVRAKDRTPDQVASVVEVCLAELDTQ
RAHTAAVVANRCELSAIPAVTDALRRFTPPSYVVPEEPLLSAPTVAELTQAVNGAVVS
GDVALREREVMGVLAAGMTADHVLERLTDGMAVITPGDRSDVVLAVASAHAAEGFPSL
SCIVLNGGFQLHPAIAALVSGLRLRLPVIATALGTYDTASAAASARGLVTATSQRKID
TALELMDRHVDVAGLLAQLTIPIPTVTTPQMFTYRLLQQARSDLMRIVLPEGDDDRIL
KSAGRLLQRGIVDLTILGDEAKVRLRAAELGVDLDGATVIEPCASELHDQFADQYAQL
RKAKGITVEHAREIMNDATYFGTMLVHNCHADGMVSGAAHTTAHTVRPALEIIKTVPG
ISTVSSIFLMCLPDRVLAYGDCAIIPNPTVEQLADIAICSARTAAQFGIEPRVAMLSY
STGDSGKGADVDKVRAATELVRAREPQLPVEGPIQYDAAVEPSVAATKLRDSPVAGRA
TVLIFPDLNTGNNTYKAVQRSAGAIAIGPVLQGLRKPVNDLSRGALVDDIVNTVAITA
IQAQGVHE"
gene 493851..495008
/gene="ackA"
/locus_tag="Rv0409"
CDS 493851..495008
/codon_start=1
/transl_table=11
/gene="ackA"
/locus_tag="Rv0409"
/product="Probable acetate kinase AckA (acetokinase)"
/note="Rv0409, (MTCY22G10.05), len: 385 aa. Probable
ackA,acetate kinase, highly similar to others e.g.
ACKA_BACSU|P37877 acetate kinase from Bacillus subtilis
(395 aa), FASTA scores: opt: 974, E(): 0, (43.5% identity
in 393 aa overlap); etc. Contains PS01075 Acetate and
butyrate kinases family signature 1, PS00758 ArgE / dapE /
ACY1/ CPG2 / yscS family signature 1. Belongs to the
acetokinase family."
/db_xref="EnsemblGenomes-Gn:Rv0409"
/db_xref="EnsemblGenomes-Tr:CCP43140"
/db_xref="GOA:P9WQH1"
/db_xref="InterPro:IPR000890"
/db_xref="InterPro:IPR004372"
/db_xref="InterPro:IPR023865"
/db_xref="UniProtKB/Swiss-Prot:P9WQH1"
/inference="protein motif:PROSITE:PS01075"
/inference="protein motif:PROSITE:PS00758"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43140.1"
/translation="MSSTVLVINSGSSSLKFQLVEPVAGMSRAAGIVERIGERSSPVA
DHAQALHRAFKMLAEDGIDLQTCGLVAVGHRVVHGGTEFHQPTLLDDTVIGKLEELSA
LAPLHNPPAVLGIKVARRLLANVAHVAVFDTAFFHDLPPAAATYAIDRDVADRWHIRR
YGFHGTSHQYVSERAAAFLGRPLDGLNQIVLHLGNGASASAIARGRPVETSMGLTPLE
GLVMGTRSGDLDPGVISYLWRTARMGVEDIESMLNHRSGMLGLAGERDFRRLRLVIET
GDRSAQLAYEVFIHRLRKYLGAYLAVLGHTDVVSFTAGIGENDAAVRRDALAGLQGLG
IALDQDRNLGPGHGARRISSDDSPIAVLVVPTNEELAIARDCLRVLGGRRA"
gene complement(495062..497314)
/gene="pknG"
/locus_tag="Rv0410c"
CDS complement(495062..497314)
/codon_start=1
/transl_table=11
/gene="pknG"
/locus_tag="Rv0410c"
/product="Serine/threonine-protein kinase PknG (protein
kinase G) (STPK G)"
/note="Rv0410c, (MTCY22G10.06c), len: 750 aa.
PknG,serine/threonine-protein kinase (see citations
below),equivalent to
PKNG_MYCLE|P57993|13092623|CAC29812.1|AL583918 probable
serine/threonine-protein kinase from Mycobacterium leprae
(767 aa). Also similar to others e.g. AB76890.1|AL159139
putative serine/threonine protein kinase from Streptomyces
coelicolor (774 aa); etc. Contains PS00108
Serine/Threonine protein kinases active-site signature.
Contains Hank's kinase subdomain. Belongs to the Ser/Thr
family of protein kinases. Structure of PknG with
inhibitor AX20017 reveals that the inhibitor-binding
pocket is shaped by a unique set of amino acid side chains
not found in any human kinase (See Scherr et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0410c"
/db_xref="EnsemblGenomes-Tr:CCP43141"
/db_xref="GOA:P9WI73"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR031634"
/db_xref="InterPro:IPR031636"
/db_xref="PDB:2PZI"
/db_xref="PDB:4Y0X"
/db_xref="PDB:4Y12"
/db_xref="UniProtKB/Swiss-Prot:P9WI73"
/inference="protein motif:PROSITE:PS00108"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43141.1"
/translation="MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDED
NFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPES
KRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHG
GLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVE
HTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYND
LKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRT
LAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQL
TGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIV
TALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLME
VRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTF
PGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVR
TLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIR
ALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDM
ANKVRPTSTF"
gene complement(497314..498300)
/gene="glnH"
/locus_tag="Rv0411c"
CDS complement(497314..498300)
/codon_start=1
/transl_table=11
/gene="glnH"
/locus_tag="Rv0411c"
/product="Probable glutamine-binding lipoprotein GlnH
(GLNBP)"
/note="Rv0411c, (MTCY22G10.07c), len: 328 aa. Probable
glnH, glutamine-binding protein, membrane-bound
lipoprotein (see citation below), equivalent to
AL035159|MLCB1450_15|T44736|4154051|CAA22704.1
glutamine-binding protein homolog from Mycobacterium
leprae (325 aa), FASTA scores: opt: 1747, E(): 0, (79.3%
identity in 328 aa overlap). Also similar to others e.g.
GLNH_BACST|P27676 glutamine-binding protein precursor from
Bacillus stearothermophilus (262 aa), FASTA scores: opt:
493, E(): 7.5e-22, (37.8% identity in 193 aa overlap);
etc. Contains PS00013 Prokaryotic membrane lipoprotein
lipid attachment site, PS01039 Bacterial extracellular
solute-binding proteins, family 3 signature. Belongs to
the bacterial extracellular solute-binding protein family
3. Presumed attached to the membrane by a lipid anchor."
/db_xref="EnsemblGenomes-Gn:Rv0411c"
/db_xref="EnsemblGenomes-Tr:CCP43142"
/db_xref="GOA:P96257"
/db_xref="InterPro:IPR001638"
/db_xref="PDB:6H1U"
/db_xref="PDB:6H20"
/db_xref="PDB:6H2T"
/db_xref="UniProtKB/TrEMBL:P96257"
/inference="protein motif:PROSITE:PS01039"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43142.1"
/translation="MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPT
PVGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDIGS
NLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVV
KTMSITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDLSGKRVCVARGTTSLRRIR
EIAPPPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPY
GVGINLDNTGLVRFVNGTLERIRNDGTWNTLYRKWLTVLGPAPAPPTPRYVD"
gene complement(498300..499619)
/locus_tag="Rv0412c"
CDS complement(498300..499619)
/codon_start=1
/transl_table=11
/locus_tag="Rv0412c"
/product="Possible conserved membrane protein"
/note="Rv0412c, (MTCY22G10.08c), len: 439 aa. Possible
conserved membrane protein, equivalent to
AL035159|MLCB1450_16|T44737 probable membrane protein from
Mycobacterium leprae (403 aa), FASTA scores: opt:
2027,E(): 0, (80.4% identity in 403 aa overlap). Also some
similarity with CAB71201.1|AL138538 putative secreted
protein from Streptomyces coelicolor (429 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0412c"
/db_xref="EnsemblGenomes-Tr:CCP43143"
/db_xref="GOA:P96258"
/db_xref="UniProtKB/TrEMBL:P96258"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43143.1"
/translation="MTVELAHPSTEPLGSRSPAEPAHPRRWFISTTPGRIMTIGIVLA
ALGVASAFATSTTIEHRQQVLTAVLDHTEPLSFAAGRLYTTLSVADAAAATAFIAQAE
PGGVRLRYEQAITDASVAVTRASSGLTDESLVQLLGRINAELAVYTGLVEIARANNRA
GNPVGSSYLSEASGLMQSTILPDAQRLYQATSARVDRETTASTQIPAPVILVVATTVV
FGAFAHRWLARRTRRRINPGLVVGALGILVMVVWVGTALTISTTASRSAKDTAAESLK
TITNLAITAQQARADETLSLIRRGDEEVRKQAFYQRIDAMQRQLNDYMARRHAVDKPD
LQGADQLLVRWRQANDRINSDISVGNYRAATQVALGKGEDDATPAFDKLDEALTKAMG
QSRTQLRHDILNAHRGLAGAQVGGVVLSLGAAIAVALGLWPRLKEYR"
gene 499713..500366
/gene="mutT3"
/locus_tag="Rv0413"
CDS 499713..500366
/codon_start=1
/transl_table=11
/gene="mutT3"
/locus_tag="Rv0413"
/product="Possible mutator protein MutT3
(7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase)
(dGTP pyrophosphohydrolase)"
/note="Rv0413, (MTCY22G10.10), len: 217 aa. Possible
mutT3,mutator protein (see citation below), showing some
similarity with e.g. MUTT_PROVU|P32090 mutator mutt
protein from Proteus vulgaris (112 aa), FASTA scores: opt:
151,E(): 0.0008, (40.7% identity in 59 aa overlap). Seems
to belong to the NUDIX hydrolase family."
/db_xref="EnsemblGenomes-Gn:Rv0413"
/db_xref="EnsemblGenomes-Tr:CCP43144"
/db_xref="GOA:P9WIX9"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR020084"
/db_xref="InterPro:IPR020476"
/db_xref="UniProtKB/Swiss-Prot:P9WIX9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43144.1"
/translation="MPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRP
DGTPAVLLQHRALWSHQGGTWGLPGGARDSHETPEQTAVRESSEEAGLSAERLEVRAT
VVTAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAELRWVAENEVADLPLHPGFAAS
WQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLGRRISSLL"
gene complement(500350..501018)
/gene="thiE"
/locus_tag="Rv0414c"
CDS complement(500350..501018)
/codon_start=1
/transl_table=11
/gene="thiE"
/locus_tag="Rv0414c"
/product="Thiamine-phosphate pyrophosphorylase ThiE (TMP
pyrophosphorylase) (TMP-PPASE) (thiamine-phosphate
synthase)"
/note="Rv0414c, (MTCY22G10.11c), len: 222 aa. thiE,
thiamin phosphate pyrophosphorylase, equivalent to
Q9ZBL5|AL035159|MLCB1450_17 probable thiamine-phosphate
pyrophosphorylase from Mycobacterium leprae (235 aa),
FASTA scores: opt: 1095, E(): 0, (78.0% identity in 223 aa
overlap). Also similar to others e.g.
T34974|5689976|CAB52013.1|AL109663 probable thiamin
phosphate pyrophosphorylase from Streptomyces coelicolor
(223 aa); THIE_ECOLI|P30137 thie protein from Escherichia
coli strain K12 (211 aa), FASTA scores: opt: 275, E():
7.8e-12, (37.8% identity in 196 aa overlap); etc. Belongs
to the TMP-PPASE family."
/db_xref="EnsemblGenomes-Gn:Rv0414c"
/db_xref="EnsemblGenomes-Tr:CCP43145"
/db_xref="GOA:P9WG75"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR022998"
/db_xref="InterPro:IPR034291"
/db_xref="InterPro:IPR036206"
/db_xref="PDB:3O63"
/db_xref="UniProtKB/Swiss-Prot:P9WG75"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43145.1"
/translation="MHESRLASARLYLCTDARRERGDLAQFAEAALAGGVDIIQLRDK
GSPGELRFGPLQARDELAACEILADAAHRYGALFAVNDRADIARAAGADVLHLGQRDL
PVNVARQILAPDTLIGRSTHDPDQVAAAAAGDADYFCVGPCWPTPTKPGRAAPGLGLV
RVAAELGGDDKPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSAL
TAAN"
gene 501148..502170
/gene="thiO"
/locus_tag="Rv0415"
CDS 501148..502170
/codon_start=1
/transl_table=11
/gene="thiO"
/locus_tag="Rv0415"
/product="Possible thiamine biosynthesis oxidoreductase
ThiO"
/note="Rv0415, (MTCY22G10.12), len: 340 aa. Possible
thiO,thiamine biosynthesis oxidoreductase, equivalent to
T44739|4154054|CAA22708.1|AL035159|MLCB1450.24
hypothetical protein from Mycobacterium leprae (340 aa),
FASTA scores: opt: 1867, E(): 0, (82.0% identity in 338 aa
overlap). Shows some similarity to other thiO proteins
e.g. THIO_RHIET|O34292 Putative thiamine biosynthesis
oxidoreductase from Rhizobium etli plasmid pb (327 aa)
(see citation below); AAG31046.1|AF264948_8|THIO putative
amino acid oxidase flavoprotein ThiO from Erwinia
amylovora (349 aa);
NP_106392.1|14025578|BAB52178.1|AP003007|THIO thiamine
biosynthesis oxidoreductase THIO from Mesorhizobium loti
(333 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0415"
/db_xref="EnsemblGenomes-Tr:CCP43146"
/db_xref="GOA:P96261"
/db_xref="InterPro:IPR006076"
/db_xref="InterPro:IPR012727"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:P96261"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43146.1"
/translation="MASDLHTGSLAVIGGGVIGLSVARRAAQAGWPVRVHRSDERGAS
WVAGGMLAPHSEGWPGEERLLRLGLQSLRLWREGSFLDGLGPQLVTAHESLVVAVDRA
DVADLRTVADWLSAQGHPVIWESAARDVEPLLAQGIRHGFRAPTELAVDNRALLDALC
RDCERLGVRWSSQVSSLSDVDAHTVVIANGIDAPALWPGLPIRPVKGEVLRLRWRPGC
MPLPQRVIRARVRGRQVYLVPRSDGVVVGATQYEHGRDTAPVVSGVRDLLDDACTVLP
ALGEYELAECEAGLRPMTPDNLPLVQRLDSRTLVAAGHGRSGFLLAPWTAEQIVSELV
SVGAAS"
gene 502167..502373
/gene="thiS"
/locus_tag="Rv0416"
CDS 502167..502373
/codon_start=1
/transl_table=11
/gene="thiS"
/locus_tag="Rv0416"
/product="Possible protein ThiS"
/note="Rv0416, (MTCY22G10.13), len: 68 aa. Possible thiS
protein, equivalent to
T44740|4154055|CAA22709.1|AL035159|MLCB1450.25
hypothetical protein from Mycobacterium leprae (74 aa),
FASTA scores: opt: 303, E(): 2e-18, (71.6% identity in 74
aa overlap). Shows weak similarity with
O32583|THIS_ECOLI|THIG1|B3991.1 this protein from
Escherichia coli strain K12 (66 aa),FASTA scores: opt:
103, E(): 0.052, (30.9% identity in 68 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0416"
/db_xref="EnsemblGenomes-Tr:CCP43147"
/db_xref="InterPro:IPR003749"
/db_xref="InterPro:IPR010035"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR016155"
/db_xref="UniProtKB/TrEMBL:P96262"
/protein_id="CCP43147.1"
/translation="MIVVVNEQQVEVDEQTTIAALLDSLGFGDRGIAVALNFSVLPRS
DWATKICELRKPVRLEVVTAVQGG"
gene 502366..503124
/gene="thiG"
/locus_tag="Rv0417"
CDS 502366..503124
/codon_start=1
/transl_table=11
/gene="thiG"
/locus_tag="Rv0417"
/product="Probable thiamin biosynthesis protein ThiG
(thiazole biosynthesis protein)"
/note="Rv0417, (MTCY22G10.14), len: 252 aa. Probable
thiG,thiamin biosynthesis protein, equivalent to
AL035159|MLCB1450_20|T44741|THIG probable thiamin
biosynthesis protein from Mycobacterium leprae (261
aa),FASTA scores: opt: 1380, E(): 0, (86.8% identity in
250 aa overlap). Also highly similar to others e.g.
SCOEDB|SC6E10.03|T35490|THIG probable thiazole
biosynthesis protein from Streptomyces coelicolor (264
aa); F82761|9105679|AAF83593.1|AE003919_4|XF0783|THIG
thiamin biosynthesis protein thiG from Xylella fastidiosa
(275 aa); P30139|THIG_ECOLI|7448315|B65206|409790|AAC43089
.1|U00006 THIG protein thiamin biosynthesis protein from
Escherichia coli strain K-12 (281 aa); etc. Belongs to the
THIG family."
/db_xref="EnsemblGenomes-Gn:Rv0417"
/db_xref="EnsemblGenomes-Tr:CCP43148"
/db_xref="GOA:P9WG73"
/db_xref="InterPro:IPR008867"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR033983"
/db_xref="PDB:5Z9Y"
/db_xref="UniProtKB/Swiss-Prot:P9WG73"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43148.1"
/translation="MAESKLVIGDRSFASRLIMGTGGATNLAVLEQALIASGTELTTV
AIRRVDADGGTGLLDLLNRLGITPLPNTAGSRSAAEAVLTAQLAREALNTNWVKLEVI
ADERTLWPDAVELVRAAEQLVDDGFVVLPYTTDDPVLARRLEDTGCAAVMPLGSPIGT
GLGIANPHNIEMIVAGARVPVVLDAGIGTASDAALAMELGCDAVLLASAVTRAADPPA
MAAAMAAAVTAGYLARCAGRIPKRFWAQASSPAR"
gene 503496..504998
/gene="lpqL"
/locus_tag="Rv0418"
CDS 503496..504998
/codon_start=1
/transl_table=11
/gene="lpqL"
/locus_tag="Rv0418"
/product="Probable lipoprotein aminopeptidase LpqL"
/note="Rv0418, (MTCCY22G10.15), len: 500 aa. Probable
lpqL,lipoprotein aminopeptidase, similar to others e.g.
B83278|9949035|AAG06327.1|AE004720_3|AE004720|PA2939
probable aminopeptidase from Pseudomonas aeruginosa (536
aa); P80561|APX_STRGR|SGAP|S66427 aminopeptidase from
Streptomyces griseus (284 aa) (homology only with
C-terminus of Rv0418); P37302|APE3_YEAST|1077010|A54134
aminopeptidase Y from Saccharomyces cerevisiae (537 aa);
etc. Contains PS00013 Prokaryotic membrane lipoprotein
lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0418"
/db_xref="EnsemblGenomes-Tr:CCP43149"
/db_xref="GOA:P96264"
/db_xref="InterPro:IPR003137"
/db_xref="InterPro:IPR007484"
/db_xref="InterPro:IPR041756"
/db_xref="UniProtKB/Swiss-Prot:P96264"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43149.1"
/translation="MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEF
AVALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQT
PEFSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDY
DRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIP
VVSVTKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVP
EGPGINDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDA
LKGIALYLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAG
KTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQK
TDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP"
gene 505086..506582
/gene="lpqM"
/locus_tag="Rv0419"
CDS 505086..506582
/codon_start=1
/transl_table=11
/gene="lpqM"
/locus_tag="Rv0419"
/product="Possible lipoprotein peptidase LpqM"
/note="Rv0419, (MTCY22G10.16), len: 498 aa. Possible
lpqM,lipoprotein peptidase ; has potential N-terminal
signal peptide and contains PS00013 Prokaryotic membrane
lipoprotein lipid attachment site, PS00142 Neutral zinc
metallopeptidases, zinc-binding region signature."
/db_xref="EnsemblGenomes-Gn:Rv0419"
/db_xref="EnsemblGenomes-Tr:CCP43150"
/db_xref="GOA:P96265"
/db_xref="UniProtKB/TrEMBL:P96265"
/inference="protein motif:PROSITE:PS00013"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43150.1"
/translation="MHGRGRYRPLVRCVRPRRVAASVRTPIACLAAVVVIAGCTTVVD
GRALSILNDPFRVGGLPATNGPSGARPDAPAASGTVINTNNGAIDKLSLLSVNDIEDY
WMAVYSESLKGTFRPVGKLVSYDSNDPSSPIVCHIDTYQLVNAFFSSRCNLIAWDRGV
FMAVAQEYFGDMSVNGVLAHEFGHALQVMANLVTRKDPTIVREQQADCFAGVYLWWVA
EGKSTRFTLSTADGLDHVLAGIITTRDPVMEADAENDDEHGSALDRVSAFQLGFINGT
PACAAIDEDEVERRRGDLPTALRVDASGNPETGEVGINEETLSTLMELMGKIFSPKNP
PTLSYQPAGCPDAKPSPPAAYCPATNTIVVDLPALARMGKVASAAEHSLPQGDDTSLS
IVMSRYALAVQHERGLPMQSPWTALRTACLTGVAHRKMAVPIDLPSGQQLVLTAGDLD
EAVSGLLTNRMVASDADGVSVPAGFTRIAAFRAGVGGDMDACYARYPG"
gene complement(506561..506971)
/locus_tag="Rv0420c"
CDS complement(506561..506971)
/codon_start=1
/transl_table=11
/locus_tag="Rv0420c"
/product="Possible transmembrane protein"
/note="Rv0420c, (MTCY22G10.17c), len: 136 aa. Possible
transmembrane protein; has potential transmembrane domains
aa 53-99 and aa 100-122."
/db_xref="EnsemblGenomes-Gn:Rv0420c"
/db_xref="EnsemblGenomes-Tr:CCP43151"
/db_xref="GOA:P96266"
/db_xref="UniProtKB/TrEMBL:P96266"
/protein_id="CCP43151.1"
/translation="MRLHDASAAAPESRMHIARHGEAVNRRQMFIGITGLLLAVIGLM
ALWFPVYLDQYDAYGIKVTCGSGWRSNLTQALYADGNDNTQALVTRCDTALLVRRAWA
IPSVALGWLLVTGFLVMWVHNDQHQGQSYPGYRA"
gene complement(507132..507761)
/locus_tag="Rv0421c"
CDS complement(507132..507761)
/codon_start=1
/transl_table=11
/locus_tag="Rv0421c"
/product="Conserved hypothetical protein"
/note="Rv0421c, (MTCY22G10.18c), len: 209 aa. Conserved
hypothetical protein, showing similarity with
NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical
protein from Mesorhizobium loti (214 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0421c"
/db_xref="EnsemblGenomes-Tr:CCP43152"
/db_xref="GOA:P96267"
/db_xref="InterPro:IPR026555"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P96267"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43152.1"
/translation="MNLDQIAGVAHQPAGPPHGVVVLTHGAGGSRESTLLQQVCAEWT
RRGWLAVRYNLPYRRRRPTGPPSGSGSGDRAGIVEAIQLCRGLAEGPLIAGGHSYGGR
QTSMVVAAGQAPVDVLTLFSYPVHPPGKPERVRTEHLPGIAVPTVFTHGTADPFGTLA
QVRSAAAMVSAPTEVVEITGARHDLGSKTLDVARLAVDAALRLSAGQIA"
gene complement(507758..508555)
/gene="thiD"
/locus_tag="Rv0422c"
CDS complement(507758..508555)
/codon_start=1
/transl_table=11
/gene="thiD"
/locus_tag="Rv0422c"
/product="Probable phosphomethylpyrimidine kinase ThiD
(HMP-phosphate kinase) (HMP-P kinase)"
/note="Rv0422c, (MTCY22G10.19c), len: 265 aa. Probable
thiD, phosphomethylpyrimidine kinase, equivalent to
AL035159|MLCB1450_21 phosphomethylpyrimidine kinase from
Mycobacterium leprae (279 aa), FASTA scores: opt:
1386,E(): 0, (77.8% identity in 266 aa overlap). Also
highly similar to others e.g. HIU32725_3|P44697|THID_HAEIN
phosphomethylpyrimidine kinase from Haemophilus influenzae
(269 aa), FASTA scores: opt: 605, E(): 0, (42.1% identity
in 259 aa overlap). Belongs to the ThiD family."
/db_xref="EnsemblGenomes-Gn:Rv0422c"
/db_xref="EnsemblGenomes-Tr:CCP43153"
/db_xref="GOA:P9WG77"
/db_xref="InterPro:IPR004399"
/db_xref="InterPro:IPR013749"
/db_xref="InterPro:IPR029056"
/db_xref="UniProtKB/Swiss-Prot:P9WG77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43153.1"
/translation="MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQ
NTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVP
LVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRA
AAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLAT
AIAAALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS"
gene complement(508582..510225)
/gene="thiC"
/locus_tag="Rv0423c"
CDS complement(508582..510225)
/codon_start=1
/transl_table=11
/gene="thiC"
/locus_tag="Rv0423c"
/product="Probable thiamine biosynthesis protein ThiC"
/note="Rv0423c, (MTCY22G10.20c), len: 547 aa. Probable
thiC, thiamin biosynthesis protein, equivalent to
Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22
thiamine biosynthesis protein from Mycobacterium leprae
(547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity
in 547 aa overlap). Also highly similar to others e.g.
P45740|THIC_BACSU thiamin biosynthesis protein from
Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E():
0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI
THIC protein from Escherichia coli strain K12 (631
aa),FASTA scores: opt: 2141, E(): 0, (62.1% identity in
568 aa overlap); etc. Belongs to the ThiC family."
/db_xref="EnsemblGenomes-Gn:Rv0423c"
/db_xref="EnsemblGenomes-Tr:CCP43154"
/db_xref="GOA:P9WG79"
/db_xref="InterPro:IPR002817"
/db_xref="InterPro:IPR025747"
/db_xref="InterPro:IPR037509"
/db_xref="InterPro:IPR038521"
/db_xref="UniProtKB/Swiss-Prot:P9WG79"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43154.1"
/translation="MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLST
GDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAAR
EDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEV
DKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELT
WEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRE
SFLYTNFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHG
AQVMIEGPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAII
AQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTA
RFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDVREYA
AEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ"
gene complement(510377..510652)
/locus_tag="Rv0424c"
CDS complement(510377..510652)
/codon_start=1
/transl_table=11
/locus_tag="Rv0424c"
/product="Hypothetical protein"
/note="Rv0424c, (MTCY22G10.21c), len: 91 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0424c"
/db_xref="EnsemblGenomes-Tr:CCP43155"
/db_xref="UniProtKB/TrEMBL:P96270"
/protein_id="CCP43155.1"
/translation="MAEKNTRRATSQREAVAKIREAETIVMNLPICGQVKIPRPEHLA
YYGGLAALAALELIDWPVALVIATGHILANNHHNRVLEELGEAMEEA"
gene complement(510702..515321)
/gene="ctpH"
/locus_tag="Rv0425c"
CDS complement(510702..515321)
/codon_start=1
/transl_table=11
/gene="ctpH"
/locus_tag="Rv0425c"
/product="Possible metal cation transporting P-type ATPase
CtpH"
/note="Rv0425c, (MTCY22G10.22c), len: 1539 aa. Possible
ctpH, metal cation-transporting P-type ATPase
(transmembrane protein), showing some similarity with
CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative
cation-transporting ATPase from Mycobacterium leprae (1609
aa). Also similar to others ATPases e.g. AE000873_1
cation-transporting P-ATPase from Methanobacterium
thermoautotrop (844 aa), FASTA score: (30.5% identity in
827 aa overlap); AB69720.1|AL137166 putative transport
ATPase from Streptomyces coelicolor (1472 aa); etc.
C-terminal region similar to other ATPases from
Mycobacterium tuberculosis e.g. Y05Q_MYCTU|Q10900 putative
cation-transporting ATPase C (855 aa), FASTA scores: opt:
770, E(): 5.3e-32, (44.9% identity in 820 aa overlap).
Nucleotide position 511518 in the genome sequence has been
corrected, T:G resulting in I1268I."
/db_xref="EnsemblGenomes-Gn:Rv0425c"
/db_xref="EnsemblGenomes-Tr:CCP43156"
/db_xref="GOA:P96271"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR006068"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/TrEMBL:P96271"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43156.1"
/translation="MPVRAVATGFRATATLTGASITAATAVSATLAKTGVGTGMKVAI
IPLRAGAKALSGELSRETLGRNCWRGERRAWIEVRGLRSGGDDELGRVVLNAIQAHPG
VGSASLNYPLSRVVVAIDDPDTSLRELCRIVDDAEKAERHRHPDQAADQLAQSPGSLP
GDGVLLAVRAVTVAATAAGLGLALGGRALRWPRFPLVIEAAVAAVDHQPLLRRLLEDR
IGTEATATVLELAMAAAHTVTLSPAALSVDLTIQALKAAECRAGARAWRRHEPQLALH
ADEPADQPQSLWPRPARSTQPVQRSVARFALIQALSAVLVGAGTRDADMAATATLVAT
PKASRTTPEAFAAALGQGLADQHAVLPLRPESLRRLDRVDAIVIDPRVLCTDDLRVAR
IRGCGADELSTAWNRAQLVLTESGLRPGWHRVPGVSASGSDSAVEALFRPMHDRLASA
VVAEAHRTGADLVSVDVDALGELRPVFDDIRPLDDGASGSLDEALARAVAELRQAGRT
VAVLSSVGKQALSAADVALGVLPPPGAGAPPWYADVLLPDLGAAWRVLHAIPAARAAR
QRGNEISGGASALGALLMLPGVRGLGPGPVTTGAAAGLLSGYLLARKVVDAQAPRPAP
AHEWHAMSVEQVRKALPSPDEQAPAKAPPSPYPARALAGGLHTAKRGAQITQAPLNAL
WQLTKAMRAELSDPLTPMLALGAMASAVLGSPVDAVMVGSVLTGNSILAASQRLRAES
RLNRLLAQQIPPARKVLAGADDQPRYIEVRAEELRPGDIIEVRTHEVVPADARVIEEV
DVEVDESALTGESLSVTKQVEPTPGVDLIERRCMLYAGTTVVSGTAVAVVTAVGPDTQ
ERRAAELVSGDLSSVGLQHQLSRLTNQAWPVSMTGGALVTGLGLLRRRGLRQAVASGI
AVTVAAVPEGMPLVATLAQQASARRLSHFGALVRIPRSVEALGRVDMVCFDKTGTLSE
NRLRVAQVRPVAGHSREEVLRCAAHAAPASNGPQVHATDVAIVQAAAAAAASGTDGAE
PGAAEPAAHLPFRSGRSFSASVSGTELTVKGAPEVVLAACEGIGSSMDDAVAELAANG
LRVIAVAHRQLTAQQAQSVVDDPDEIARLCRDELSLVGFLGLSDTPRAQAAALLADLH
EHDLDIRLITGDHPITAAAIAEELGMQVSPEQVISGAEWDALSRKDQERAVAERVIFA
RMTPENKVQIVQTLEHSGRVCAMVGDGSNDAAAIRAATVGIGVVAHGSDPARVAADLV
LVDGRIESLLPAILEGRQLWQRVQAAVSVLLGGNAGEVAFAIIGSAITGTSPLNTRQL
LLVNMLTDALPAAALAVSKPSDPVTPATRGPDQRELWRAVGIRGATTAAAATVAWVMA
GFTGLPRRASTVALVALVAAQLGQTLVDSHAWLVVLTALGSLAALATLISIPVVSQLL
GCTPLDPLGWAQATAAATAATVAVAVLNRVLTGRDKSGQPNPQPPETDALSRDASPGA
PPGPRRRRRATARRKAPVKAPSATRQTTKPKGPPAHRSSSTYPRR"
gene complement(515373..515816)
/locus_tag="Rv0426c"
CDS complement(515373..515816)
/codon_start=1
/transl_table=11
/locus_tag="Rv0426c"
/product="Possible transmembrane protein"
/note="Rv0426c, (MTCY22G10.23c), len: 147 aa. Possible
transmembrane protein; has potential transmembrane domains
aa 19-41, and aa 61-83."
/db_xref="EnsemblGenomes-Gn:Rv0426c"
/db_xref="EnsemblGenomes-Tr:CCP43157"
/db_xref="GOA:P96272"
/db_xref="UniProtKB/TrEMBL:P96272"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43157.1"
/translation="MSVVGGTVRTVGRTVSGAATATTAAAGAVGGAAVSGIVGGVTGA
AKGIQKGLSSGSKSTAAAALAIGAIGVAGLVDWPILLAVGGGALLLRKLNRTPEVAAP
PVKAKLAPVPDKPAAAKEAPAKASKTTARKTSGRRAGTAELRSTN"
gene complement(516017..516892)
/gene="xthA"
/gene_synonym="xth"
/locus_tag="Rv0427c"
CDS complement(516017..516892)
/codon_start=1
/transl_table=11
/gene="xthA"
/gene_synonym="xth"
/locus_tag="Rv0427c"
/product="Probable exodeoxyribonuclease III protein XthA
(exonuclease III) (EXO III) (AP endonuclease VI)"
/note="Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable
xthA (alternate gene name: xth), exodeoxyribonuclease III
protein (see citation below), similar to others e.g.
EX3_ECOLI|P09030 exodeoxyribonuclease III from Escherichia
Coli strain K12 (268 aa), FASTA scores: opt: 360, E():
1.2e-17, (29.3% identity in 270 aa overlap); etc. Belongs
to the AP/EXOA family of DNA repair enzymes."
/db_xref="EnsemblGenomes-Gn:Rv0427c"
/db_xref="EnsemblGenomes-Tr:CCP43158"
/db_xref="GOA:P96273"
/db_xref="InterPro:IPR004808"
/db_xref="InterPro:IPR005135"
/db_xref="InterPro:IPR036691"
/db_xref="InterPro:IPR037493"
/db_xref="UniProtKB/TrEMBL:P96273"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43158.1"
/translation="MPDGTIDGGHPQRPASPRLRSPLLRLATWNVNSIRTRLDRVLDW
LGRADVDVLAMQETKCPDGQFPALPLFELGYDVAHVGFDQWNGVAIASRVGLDDVRVG
FDGQPSWSGKPEVAATTEARALGATCGGIRVWSLYVPNGRALDDPHYTYKLDWLAALR
DTAEGWLRDDPAAPIALMGDWNIAPTDDDVWSTEFFAGCTHVSEPERKAFNAIVDAQF
TDVVRPFTPGPGVYTYWDYTQLRFPKKQGMRIDFILGSPALAARVMDAQIVREERKGK
APSDHAPVLVDLHAG"
gene complement(516895..517803)
/locus_tag="Rv0428c"
CDS complement(516895..517803)
/codon_start=1
/transl_table=11
/locus_tag="Rv0428c"
/product="GCN5-related N-acetyltransferase"
/note="Rv0428c, (MTCY22G10.25c), len: 302 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain in C-terminal part. See
Vetting et al. 2005."
/db_xref="EnsemblGenomes-Gn:Rv0428c"
/db_xref="EnsemblGenomes-Tr:CCP43159"
/db_xref="GOA:P96274"
/db_xref="UniProtKB/TrEMBL:P96274"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43159.1"
/translation="MVSWPGLGTRVTVRYRRPAGSMPPLTDAVGRLLAVDPTVRVQTK
TGTIVEFSPVDVVALRVLTDAPVRTAAIRALEHAAAAAWPGVERTWLDGWLLRAGHGA
VLAANSAVPLDISAHTNTITEISAWYASRDLQPWLAVPDRLLPLPADLAGERREQVLV
RDVSTGEPDRSVTLLDHPDDTWLRLYHQRLPLDMATPVIDGELAFGSYLGVAVARAAV
TDAPDGTRWVGLSAMRAADEQSATGSAGRQLWEALLGWGAGRGATRGYVRVHDTATSV
LAESLGFRLHHHCRYLPAQSVGWDTF"
gene complement(517803..518396)
/gene="def"
/locus_tag="Rv0429c"
CDS complement(517803..518396)
/codon_start=1
/transl_table=11
/gene="def"
/locus_tag="Rv0429c"
/product="Probable polypeptide deformylase Def (PDF)
(formylmethionine deformylase)"
/note="Rv0429c, (MTCY22G10.26c), len: 197 aa. Probable
def,polypeptide deformylase, equivalent to
CAC30884.1|AL583923 polypeptide deformylase from
Mycobacterium leprae (197 aa). Also similar to others e.g.
DEF_ECOLI|P27251|95874|S23107 polypeptide deformylase from
Escherichia coli (169 aa),FASTA scores: opt: 179, E():
1.8e-05, (34.6% identity in 162 aa overlap); etc. Belongs
to the polypeptide deformylase family. Cofactor: binds 1
zinc ion."
/db_xref="EnsemblGenomes-Gn:Rv0429c"
/db_xref="EnsemblGenomes-Tr:CCP43160"
/db_xref="GOA:P9WIJ3"
/db_xref="InterPro:IPR023635"
/db_xref="InterPro:IPR036821"
/db_xref="PDB:3E3U"
/db_xref="UniProtKB/Swiss-Prot:P9WIJ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43160.1"
/translation="MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTM
DAANGVGLAANQIGCSLRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTD
DEGCLSVPGESFPTGRAKWARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLD
RLIGRYARNAKRAVKSHGWGVPGLSWLPGEDPDPFGH"
gene 518733..519041
/locus_tag="Rv0430"
CDS 518733..519041
/codon_start=1
/transl_table=11
/locus_tag="Rv0430"
/product="Conserved hypothetical protein"
/note="Rv0430, (MTCY22G10.27), len: 102 aa. Conserved
hypothetical protein, equivalent to AC30882.1|AL583923
conserved hypothetical protein from Mycobacterium leprae
(102 aa). Also highly similar to
CAB93047.1|SCD95A.20|AL357432 hypothetical protein from
Streptomyces coelicolor (84 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0430"
/db_xref="EnsemblGenomes-Tr:CCP43161"
/db_xref="GOA:P96276"
/db_xref="InterPro:IPR021678"
/db_xref="UniProtKB/TrEMBL:P96276"
/protein_id="CCP43161.1"
/translation="MDSAMARAIRSGDDAEVADGLTRREHDILAFERQWWKFAGVKEE
AIKELFSMSATRYYQVLNALVDRPEALAADPMLVKRLRRLRASRQKARAARRLGFEVT
"
gene 519073..519567
/locus_tag="Rv0431"
CDS 519073..519567
/codon_start=1
/transl_table=11
/locus_tag="Rv0431"
/product="Putative tuberculin related peptide"
/note="Rv0431, (MTCY22G10.28), len: 164 aa. Putative
tuberculin related peptide; almost identical to
D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis
(172 aa), FASTA score: (99.4% identity in 163 aa overlap).
Highly similar to to CAC30881.1|AL583923 tuberculin
related peptide (AT103) from Mycobacterium leprae (167
aa). Some similarity to G550415|HRPC (282 aa), FASTA
scores: opt: 120, E(): 0.36, (33.3% identity in 111 aa
overlap). Potential transmembrane domain at aa 19-37."
/db_xref="EnsemblGenomes-Gn:Rv0431"
/db_xref="EnsemblGenomes-Tr:CCP43162"
/db_xref="GOA:P96277"
/db_xref="InterPro:IPR027381"
/db_xref="UniProtKB/TrEMBL:P96277"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43162.1"
/translation="MLVTVGSMNERVPDSSGLPLRAMVMVLLFLGVVFLLLVWQALGS
SPNSEDDSSAISTMTTTTAAPTSTSVKPAAPRAEVRVYNISGTEGAAARTADRLKAAG
FTVTDVGNLSLPDVAATTVYYTEVEGERATADAVGRTLGAAVELRLPELSDQPPGVIV
VVTG"
gene 519600..520322
/gene="sodC"
/locus_tag="Rv0432"
CDS 519600..520322
/codon_start=1
/transl_table=11
/gene="sodC"
/locus_tag="Rv0432"
/product="Periplasmic superoxide dismutase [Cu-Zn] SodC"
/note="Rv0432, (MTCY22G10.29), len: 240 aa.
sodC,periplasmic superoxide dismutase [Cu-Zn], equivalent
to CAC30880.1|AL583923 superoxide dismutase precursor
(Cu-Zn) from Mycobacterium leprae (240 aa); and
AAK20038.1|AF326234_1 copper zinc superoxide dismutase
from Mycobacterium avium subsp. paratuberculosis (226 aa).
Also similar to others e.g. SODC_PHOLE|P00446 superoxide
dismutase precursor (Cu-Zn) from Photobacterium leiognathi
(173 aa), FASTA scores: opt: 214, E(): 5.2 e-06, (36.5%
identity in 181 aa overlap). Contains PS00013 Prokaryotic
membrane lipoprotein lipid attachment site. Belongs to the
Cu-Zn superoxide dismutase family. Possibly localized in
periplasm, membrane-bound."
/db_xref="EnsemblGenomes-Gn:Rv0432"
/db_xref="EnsemblGenomes-Tr:CCP43163"
/db_xref="GOA:P9WGE9"
/db_xref="InterPro:IPR001424"
/db_xref="InterPro:IPR018152"
/db_xref="InterPro:IPR024134"
/db_xref="InterPro:IPR036423"
/db_xref="PDB:1PZS"
/db_xref="UniProtKB/Swiss-Prot:P9WGE9"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43163.1"
/translation="MPKPADHRNHAAVSTSVLSALFLGAGAALLSACSSPQHASTVPG
TTPSIWTGSPAPSGLSGHDEESPGAQSLTSTLTAPDGTKVATAKFEFANGYATVTIAT
TGVGKLTPGFHGLHIHQVGKCEPNSVAPTGGAPGNFLSAGGHYHVPGHTGTPASGDLA
SLQVRGDGSAMLVTTTDAFTMDDLLSGAKTAIIIHAGADNFANIPPERYVQVNGTPGP
DETTLTTGDAGKRVACGVIGSG"
gene 520324..521454
/locus_tag="Rv0433"
CDS 520324..521454
/codon_start=1
/transl_table=11
/locus_tag="Rv0433"
/product="Conserved hypothetical protein"
/note="Rv0433, (MTCY22G10.30), len: 376 aa. Conserved
hypothetical protein, similar to other hypothetical
proteins e.g. P77213|YBDK_ECOLI hypothetical 41.7 KD
protein from Escherichia coli strain K12 (372 aa), FASTA
scores: opt: 555, E(): 2e-30, (28.2% identity in 365 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0433"
/db_xref="EnsemblGenomes-Tr:CCP43164"
/db_xref="GOA:P9WPK9"
/db_xref="InterPro:IPR006336"
/db_xref="InterPro:IPR011793"
/db_xref="InterPro:IPR014746"
/db_xref="UniProtKB/Swiss-Prot:P9WPK9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43164.1"
/translation="MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVI
AEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGT
HPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNY
YPHLLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTG
IIDHMDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGET
LPTMPPWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCAD
ELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI"
gene 521514..522167
/locus_tag="Rv0434"
CDS 521514..522167
/codon_start=1
/transl_table=11
/locus_tag="Rv0434"
/product="Conserved hypothetical protein"
/note="Rv0434, (MTCY22G10.31), len: 217 aa. Conserved
hypothetical protein, similar to AE002052_2 from
Deinococcus radiodurans (213 aa), FASTA scores: opt:
258,E(): 4e-10, (31.9% identity in 213 aa overlap);
SYCSLRB_122|Q55701 hypothetical 24.5 kDa protein from
Synechocystis (214 aa), FASTA scores: opt: 156, E():
0.00041, (28.4% identity in 204 aa overlap);
MXABSGA_1|LON2_MYXXA|P36774 ATP-dependent protease la 2
from Myxococcus xanthus (826 aa), FASTA scores: opt:
160,E(): 0.00068, (28.4% identity in 197 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv0434"
/db_xref="EnsemblGenomes-Tr:CCP43165"
/db_xref="InterPro:IPR003111"
/db_xref="InterPro:IPR015947"
/db_xref="UniProtKB/TrEMBL:P96280"
/protein_id="CCP43165.1"
/translation="MADFAPVELAMFPLESAPLPDEDLPLHIFEPRYAALVRDCMDTA
DPRFGVVLISRGREVGGGDTRCDVGTLARITECADAGSGRYMLRCRVGERIRVCDWLP
DDPYPRAKVRFWPDQPGHPVTAAQLLEVEDRVVALFERIAAARGVRLPAREVVLGYPV
VDPADTGQRLYALACRVPMGPADRYAVLATPSAADRLVRLGDALDSVAAMVEFELST"
gene complement(522347..524533)
/locus_tag="Rv0435c"
CDS complement(522347..524533)
/codon_start=1
/transl_table=11
/locus_tag="Rv0435c"
/product="Putative conserved ATPase"
/note="Rv0435c, (MTCY22G10.32c), len: 728 aa. Putative
conserved ATPase, similar to others e.g. SAV_SULAC|Q07590
sav protein involved in cell division from sulfolobus
acidocaldarius (780 aa), FASTA scores: opt: 897, E():
0,(34.5% identity in 693 aa overlap);
NP_148637.1|7435761|B72479 transitional endoplasmic
reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also
similar to Rv3610c and Rv2115c from Mycobacterium
tuberculosis. Contains PS00017 ATP/GTP-binding site motif
A (P-loop), and PS00674 AAA-protein family signature."
/db_xref="EnsemblGenomes-Gn:Rv0435c"
/db_xref="EnsemblGenomes-Tr:CCP43166"
/db_xref="GOA:P96281"
/db_xref="InterPro:IPR003338"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR003960"
/db_xref="InterPro:IPR009010"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041569"
/db_xref="UniProtKB/TrEMBL:P96281"
/inference="protein motif:PROSITE:PS00674"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43166.1"
/translation="MTHPDPARQLTLTARLNTSAVDSRRGVVRLHPNAIAALGIREWD
AVSLTGSRTTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGARSVT
LSGSTLATQSVPPVTLRQALLGKVMTVGDAVSLLPRDLGPGTSTSAASRALAAAVGIS
WTSELLTVTGVDPDGPVSVQPNSLVTWGAGVPAAMGTSTAGQVSISSPEIQIEELKGA
QPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCDGRRLVTL
DGPEIGALAAGDRVKAVASAVQAVRHEGGVLLITDADALLPAAAEPVASLILSELRTA
VATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTGDL
NLDEIASRTPGFVVADLAALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSR
SASDEVTVGDVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPG
CGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDEL
DALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRL
ERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALT
AMRRSIDAANVTAADLATARETVRASLDPLQVASLRKFGTKGDLRS"
gene complement(524530..525390)
/gene="pssA"
/locus_tag="Rv0436c"
CDS complement(524530..525390)
/codon_start=1
/transl_table=11
/gene="pssA"
/locus_tag="Rv0436c"
/product="Probable CDP-diacylglycerol--serine
O-phosphatidyltransferase PssA (PS synthase)
(phosphatidylserine synthase)"
/note="Rv0436c, (MTCY22G10.33c), len: 286 aa. Probable
pssA, PS synthase (CDP-diacylglycerol--serine
O-phosphatidyltransferase) (see citation below), integral
membrane protein, equivalent to AL035159|MLCB1450_9|T44730
from Mycobacterium leprae (300 aa), FASTA scores: opt:
1506, E(): 0, (77.9% identity in 285 aa overlap). Also
highly similar to others e.g.
NP_108059.1|14027250|BAB54204.1|AP003012
phosphatidylserine synthase from Mesorhizobium loti (248
aa); PSS_BACSU|P39823 cdp-diacylglycerol--serine
o-phosphatidyltransferase from Bacillus subtilis (177 aa),
FASTA scores: opt: 277, E(): 9.9e-12, (33.3% identity in
183 aa overlap); etc. Contains PS00379 CDP-alcohol
phosphatidyltransferases signature. Belongs to the
CDP-alcohol phosphatidyltransferase class-I family."
/db_xref="EnsemblGenomes-Gn:Rv0436c"
/db_xref="EnsemblGenomes-Tr:CCP43167"
/db_xref="GOA:P9WPG1"
/db_xref="InterPro:IPR000462"
/db_xref="InterPro:IPR004533"
/db_xref="UniProtKB/Swiss-Prot:P9WPG1"
/inference="protein motif:PROSITE:PS00379"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43167.1"
/translation="MIGKPRGRRGVNLQILPSAMTVLSICAGLTAIKFALEHQPKAAM
ALIAAAAILDGLDGRVARILDAQSRMGAEIDSLADAVNFGVTPALVLYVSMLSKWPVG
WVVVLLYAVCVVLRLARYNALQDDGTQPAYAHEFFVGMPAPAGAVSMIGLLALKMQFG
EGWWTSGWFLSFWVTGTSILLVSGIPMKKMHAVSVPPNYAAALLAVLAICAAAAVLAP
YLLIWVIIIAYMCHIPFAVRSQRWLAQHPEVWDDKPKQRRAVRRASRRAHPYRPSMAR
LGLRKPGRRL"
gene complement(525387..526082)
/gene="psd"
/locus_tag="Rv0437c"
CDS complement(525387..526082)
/codon_start=1
/transl_table=11
/gene="psd"
/locus_tag="Rv0437c"
/product="Possible phosphatidylserine decarboxylase Psd
(PS decarboxylase)"
/note="Rv0437c, (MTV037.01c), len: 231 aa (start
uncertain). Possible psd, phosphatidylserine decarboxylase
, equivalent to CAC29819.1|AL583918 conserved hypothetical
protein from Mycobacterium leprae (243 aa); and highly
similar to MLCB1450.11|T44729|4154044|CAA22695.1|AL035159
hypothetical protein from Mycobacterium leprae (202
aa),FASTA score: (74.6% identity in 197 aa overlap). Also
similar to other phosphatidylserine decarboxylases e.g.
NP_108058.1|14027249|BAB54203.1|AP003012
phosphatidylserine decarboxylase from Mesorhizobium loti
(232 aa); AAK86872|g15156090|AGR_C_1963 phosphatidylserine
decarboxylase from Agrobacterium tumefaciens (244 aa);
AAG12422.1|AY005137|Psd phosphatidylserine decarboxylase
from Chlorobium tepidum (216 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0437c"
/db_xref="EnsemblGenomes-Tr:CCP43168"
/db_xref="GOA:P9WHQ5"
/db_xref="InterPro:IPR003817"
/db_xref="InterPro:IPR033175"
/db_xref="UniProtKB/Swiss-Prot:P9WHQ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43168.1"
/translation="MARRPRPDGPQHLLALVRSAVPPVHPAGRPFIAAGLAIAAVGHR
YRWLRGTGLLAAAACAGFFRHPQRVPPTRPAAIVAPADGVICAIDSAAPPAELSMGDT
PLPRVSIFLSILDAHVQRAPVSGEVIAVQHRPGRFGSADLPEASDDNERTSVRIRMPN
GAEVVAVQIAGLVARRIVCDAHVGDKLAIGDTYGLIRFGSRLDTYLPAGAEPIVNVGQ
RAVAGETVLAECR"
gene complement(526143..527360)
/gene="moeA2"
/gene_synonym="moeA3"
/locus_tag="Rv0438c"
CDS complement(526143..527360)
/codon_start=1
/transl_table=11
/gene="moeA2"
/gene_synonym="moeA3"
/locus_tag="Rv0438c"
/product="Probable molybdopterin biosynthesis protein
MoeA2"
/note="Rv0438c, (MTV037.02c), len: 405 aa. Probable
moeA2,molybdenum cofactor biosynthesis protein, highly
similar to many e.g. Y10817|ANY10817_2 from A.
nicotinovorans (429 aa), FASTA scores: opt: 786, E(): 0,
(39.2% identity in 398 aa overlap); etc. Also similar to
MOEA1|Rv0994|MTCI237.08|O05577 probable molybdopterin
biosynthesis protein from Mycobacterium tuberculosis (426
aa), FASTA scores: opt: 667, E(): 2e-32, (36.5% identity
in 425 aa overlap). Note that previously known as moeA3."
/db_xref="EnsemblGenomes-Gn:Rv0438c"
/db_xref="EnsemblGenomes-Tr:CCP43169"
/db_xref="GOA:P9WJQ5"
/db_xref="InterPro:IPR001453"
/db_xref="InterPro:IPR005110"
/db_xref="InterPro:IPR005111"
/db_xref="InterPro:IPR036135"
/db_xref="InterPro:IPR036425"
/db_xref="InterPro:IPR036688"
/db_xref="InterPro:IPR038987"
/db_xref="UniProtKB/Swiss-Prot:P9WJQ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43169.1"
/translation="MRSVQEHQRVVAEMMRACRPITVPLTQAQGLVLGGDVVAPLSLP
VFDNSAMDGYAVRAEDTSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGAPV
PTGATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLG
LAAALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAV
VATATAGDDVAQFGAILDRYAVDADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVE
FVKVAMQPGMPQGVGRVAGTPIVTLPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHR
SAVLTASLTSPRGKRQFRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVE
VAAGTQLQVWDLT"
gene complement(527379..528314)
/locus_tag="Rv0439c"
CDS complement(527379..528314)
/codon_start=1
/transl_table=11
/locus_tag="Rv0439c"
/product="Probable dehydrogenase/reductase"
/note="Rv0439c, (MTV037.03c), len: 311 aa. Probable
dehydrogenase/reductase, equivalent to
AL035159|MLCB1450_6|T44727 probable oxidoreductase from
Mycobacterium leprae (304 aa), FASTA scores: opt:
1360,E(): 0, (69.2% identity in 302 aa overlap). Also
highly similar to various oxidoreductases, generally
dehydrogenases/reductases e.g.
PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916
probable short chain dehydrogenase from Pseudomonas
aeruginosa (309 aa); Q03326|OXIR_STRAT probable
oxidoreductase from Streptomyces antibioticus (298
aa),FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity
in 298 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0439c"
/db_xref="EnsemblGenomes-Tr:CCP43170"
/db_xref="GOA:O53726"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53726"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43170.1"
/translation="MTANDNKTRKWSAADVPDQSGRVVVVTGANTGIGYHTAAVFADR
GAHVVLAVRNLEKGNAARARIMAARPGAHVTLQQLDLCSLDSVRAAADALRTAYPRID
VLINNAGVMWTPKQVTKDGFELQFGTNHLGHFALTGLVLDHMLPVPGSRVVTVSSQGH
RIHAAIHFDDLQWERRYNRVAAYGQAKLANLLFTYELQRRLGEAGKSTIAVAAHPGGS
NTELTRNLPRLIRPVATVLGPLLFQSPEMGALPTLRAATDPTTQGGQYYGPDGFGEQR
GHPKVVQSSAQSHDKDLQRRLWTVSEELTGVSFGV"
gene 528608..530230
/gene="groEL2"
/gene_synonym="groEL-2"
/gene_synonym="groL2"
/gene_synonym="hsp60"
/gene_synonym="hsp65"
/locus_tag="Rv0440"
CDS 528608..530230
/codon_start=1
/transl_table=11
/gene="groEL2"
/gene_synonym="groEL-2"
/gene_synonym="groL2"
/gene_synonym="hsp60"
/gene_synonym="hsp65"
/locus_tag="Rv0440"
/product="60 kDa chaperonin 2 GroEL2 (protein CPN60-2)
(GroEL protein 2) (65 kDa antigen) (heat shock protein 65)
(cell wall protein A) (antigen A)"
/note="Rv0440, (MTV037.04), len: 540 aa. GroEL2 (alternate
gene names: groL2, groEL-2, hsp65, hsp60), 60 kDa
chaperonin 2 (see Shinnick 1987). Purified 65 kDa antigen
can elicit a strong delayed-type hypersensitivity reaction
in experimental animals infected with M. tuberculosis.
This protein is one of the major immunoreactive proteins
of the mycobacteria. This antigen contains epitopes that
are common to various species of mycobacteria. Contains
PS00296 Chaperonins cpn60 signature. Belongs to the
chaperonin (HSP60) family. Phosphorylated in vitro by
PknJ|Rv2088 (See Arora et al., 2010)."
/db_xref="EnsemblGenomes-Gn:Rv0440"
/db_xref="EnsemblGenomes-Tr:CCP43171"
/db_xref="GOA:P9WPE7"
/db_xref="InterPro:IPR001844"
/db_xref="InterPro:IPR002423"
/db_xref="InterPro:IPR018370"
/db_xref="InterPro:IPR027409"
/db_xref="InterPro:IPR027410"
/db_xref="InterPro:IPR027413"
/db_xref="PDB:1SJP"
/db_xref="PDB:3RTK"
/db_xref="UniProtKB/Swiss-Prot:P9WPE7"
/inference="protein motif:PROSITE:PS00296"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43171.1"
/translation="MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWG
APTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREG
LRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLI
AEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYI
LLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKA
PGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGA
GDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKH
RIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQ
IAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIA
GLFLTTEAVVADKPEKEKASVPGGGDMGGMDF"
gene complement(530296..530724)
/locus_tag="Rv0441c"
CDS complement(530296..530724)
/codon_start=1
/transl_table=11
/locus_tag="Rv0441c"
/product="Hypothetical protein"
/note="Rv0441c, (MTV037.05c), len: 142 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0441c"
/db_xref="EnsemblGenomes-Tr:CCP43172"
/db_xref="UniProtKB/Swiss-Prot:P9WKW3"
/protein_id="CCP43172.1"
/translation="MGAKKVDLKRLAAALPDYPFAYLITVDDGHRVHTVAVEPVLREL
PDGPDGPRAVVDVGLIGGRTRQNLAHRSEVTLLWPPSDPSGYSLIVDGRAQASDAGPD
DDTARCGVVPIRALLHRDAAPDSPTAAKGCLHDCVVFSVP"
gene complement(530751..532214)
/gene="PPE10"
/locus_tag="Rv0442c"
CDS complement(530751..532214)
/codon_start=1
/transl_table=11
/gene="PPE10"
/locus_tag="Rv0442c"
/product="PPE family protein PPE10"
/note="Rv0442c, (MTV037.06c), len: 487 aa. PPE10, Member
of the Mycobacterium tuberculosis PPE family, nearly
identical to hypothetical protein from Mycobacterium
tuberculosis (strain Erdman) and to AN5S46909_1 protein
fragment from Mycobacterium bovis (302 aa);
P42611|YHS6_MYCTU hypothetical 50.6 kDa protein (517 aa),
FASTA scores: opt: 3144, E(): 0, (98.4 identity in 492 aa
overlap); and S46909|S46909_1 (302 aa), FASTA scores: opt:
1897, E(): 0,(98.0% identity in 302 aa overlap).
Nucleotide position 532097 in the genome sequence has been
corrected, T:C resulting in K40E."
/db_xref="EnsemblGenomes-Gn:Rv0442c"
/db_xref="EnsemblGenomes-Tr:CCP43173"
/db_xref="GOA:P9WI41"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI41"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43173.1"
/translation="MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEELLAS
IASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEA
ALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFD
ASAAVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTG
NIGSGNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGN
SGTGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAAL
GSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPV
AAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAV
REPSTPGSGIPKSNFYPSPDRESAYASPRIGQPVGSE"
gene 532396..532911
/locus_tag="Rv0443"
CDS 532396..532911
/codon_start=1
/transl_table=11
/locus_tag="Rv0443"
/product="Conserved protein"
/note="Rv0443, (MTV037.07), len: 171 aa. Conserved
protein,highly similar to AL049863|SC5H1_23|T35339
hypothetical protein from Streptomyces coelicolor (171
aa), FASTA scores: opt: 561, E(): 2.3e-32, (49.7% identity
in 165 aa overlap); and CAC42482.1|AJ318385 hypothetical
protein from Amycolatopsis mediterranei (163 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0443"
/db_xref="EnsemblGenomes-Tr:CCP43174"
/db_xref="InterPro:IPR007061"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/TrEMBL:O53728"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43174.1"
/translation="MASTDAAAQELLRDAFTRLIEHVDELTDGLTDQLACYRPTPSAN
SIAWLLWHSARVQDIQVAHVAGVEEVWTRDGWVDRFGLDLPRHDTGYGHRPEDVAKVR
APADLLSGYYHAVHKLTLEYIAGMTADELSRVVDTSWNPPVTVSARLVSIVDDCAQHL
GQAAYLRGIAR"
gene complement(533091..533789)
/gene="rskA"
/locus_tag="Rv0444c"
CDS complement(533091..533789)
/codon_start=1
/transl_table=11
/gene="rskA"
/locus_tag="Rv0444c"
/product="Anti-sigma factor RskA (regulator of sigma K)"
/note="Rv0444c, (MTV037.08c), len: 232 aa. RskA, regulator
of SigK (See Said-Salim et al., 2006); C-terminus similar
to P12752|Y24K_STRGR hypothetical 24.7 kDa protein from
Streptomyces griseus (238 aa), FASTA scores: opt: 207,
E(): 2.2e-05, (32.9% identity in 158 aa overlap). Cleaved
by Rip|Rv2869c, in M. tuberculosis Erdman (See Sklar et
al.,2010)."
/db_xref="EnsemblGenomes-Gn:Rv0444c"
/db_xref="EnsemblGenomes-Tr:CCP43175"
/db_xref="GOA:P9WGX5"
/db_xref="InterPro:IPR018764"
/db_xref="PDB:4NQW"
/db_xref="UniProtKB/Swiss-Prot:P9WGX5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43175.1"
/translation="MTEHTDFELLELATPYALNAVSDDERADIDRRVAAAPSPVAAAF
NDEVRAVRETMAVVSAATTAEPPAHLRTAILDATKPEVRRQSRWRTAAFASAAAIAVG
LGAFGLGVLTRPSPPPTVAEQVLTAPDVRTVSRPLGAGTATVVFSRDRNTGLLVMNNV
APPSRGTVYQMWLLGGAKGPRSAGTMGTAAVTPSTTATLTDLGASTALAFTVEPGTGS
PQPTGTILAELPLG"
gene complement(533833..534396)
/gene="sigK"
/locus_tag="Rv0445c"
CDS complement(533833..534396)
/codon_start=1
/transl_table=11
/gene="sigK"
/locus_tag="Rv0445c"
/product="Alternative RNA polymerase sigma factor SigK"
/note="Rv0445c, (MTV037.09c), len: 187 aa.
sigK,alternative RNA polymerase sigma factor (see
citations below), highly similar to others e.g.
5531433|CAB50938.1|AL096849|T36745 probable RNA polymerase
sigma factor from Streptomyces coelicolor (185 aa);
NP_105607.1|14024791|BAB51393.1|AP003005 RNA polymerase
sigma factor from Mesorhizobium loti (179 aa);
1654108|AAB17906.1|U11283|A58883 probable transcription
initiation factor sigma E from Rhodobacter phaeroides (168
aa), FASTA scores: opt: 299, E(): 2e-14, (32.7% identity
in 168 aa overlap); Q45585|SIGW_BACSU RNA polymerase sigma
factor SIGW from Bacillus subtilis (187 aa), FASTA scores:
opt: 213, E(): 2.9e-08, (26.8% identity in 179 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0445c"
/db_xref="EnsemblGenomes-Tr:CCP43176"
/db_xref="GOA:P9WGH7"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR007630"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039425"
/db_xref="PDB:4NQW"
/db_xref="UniProtKB/Swiss-Prot:P9WGH7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43176.1"
/translation="MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVYGLVMRV
LRDTGYSEETTQEIYLEVWRNASEFDSAKGSALAWLLTMAHRRAVDRVRCEQAGNQRE
VRYGAANVDPASDVVADLAIAGDERRRVTECLKALTDTQRQCIELAYYGGLTYVEVSR
RLAANLSTIKSRMRDALRSLRNCLDVS"
gene complement(534445..535215)
/locus_tag="Rv0446c"
CDS complement(534445..535215)
/codon_start=1
/transl_table=11
/locus_tag="Rv0446c"
/product="Possible conserved transmembrane protein"
/note="Rv0446c, (MTV037.10c), len: 256 aa. Possible
conserved transmembrane protein, similar at N-terminus to
U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117
aa), FASTA scores: opt: 175, E(): 2.5e-05, (62.5% identity
in 40 aa overlap); and at C-terminus to AL021529|SC10A5_3
from Streptomyces coelicolor (226 aa), FASTA scores: opt:
207, E(): 9.8e-07, (34.2% identity in 114 aa overlap).
Also similar to others hypothetical proteins e.g.
AAK04680.1|AE006291_14|AE006291 hypothetical protein from
Lactococcus lactis subsp. lactis (257 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0446c"
/db_xref="EnsemblGenomes-Tr:CCP43177"
/db_xref="GOA:O53731"
/db_xref="InterPro:IPR001104"
/db_xref="InterPro:IPR010721"
/db_xref="UniProtKB/TrEMBL:O53731"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43177.1"
/translation="MVTSVSALAVAVVHSVAFAIGRRIGRYNVVDVVWGLGFVAVAVA
AATLGHGDPVRRWLLLALVSTWGLRLSWHMYRKTAGQGEDPRYADLLRGATPVQALRK
VFGLQGLLTLFVSFPLQLSAVTGPTPKPLLAVGGVGLAVWLVGITFEAVGDWQLWVFK
SDPANRGVIMDRGLWAWTRHPNYFGDACVWWGLWLITINDWAPLATVGSPLLMTYLLV
DVSGARLTERYLKGRPGFAEYQRRTAYFVPRPPRSARR"
gene complement(535224..536507)
/gene="ufaA1"
/locus_tag="Rv0447c"
CDS complement(535224..536507)
/codon_start=1
/transl_table=11
/gene="ufaA1"
/locus_tag="Rv0447c"
/product="Probable cyclopropane-fatty-acyl-phospholipid
synthase UfaA1 (cyclopropane fatty acid synthase) (CFA
synthase)"
/note="Rv0447c, (MTV037.11c), len: 427 aa (start
uncertain). Probable
ufaA1,cyclopropane-fatty-acyl-phospholipid synthase,
similar to others e.g.
NP_102178.1|14021351|BAB47964.1|AP002994
cyclopropane-fatty-acyl-phospholipid synthase from
Mesorhizobium loti (378 aa);
B82240|9655593|AAF94281.1|AE004192
cyclopropane-fatty-acyl-phospholipid synthase from Vibrio
cholerae (432 aa); P30010|CFA_ECOLI
cyclopropane-fatty-acyl-phospholipid synthase from
Escherichia coli strain K-12 (382 aa); X55704|PPLPD_3
LPD-3 from P.putida (394 aa), FASTA scores: opt: 556, E():
2.8e-30, (33.3% identity in 387 aa overlap);
AE0005|HPAE000557_9 from Helicobacter pylori (389
aa),FASTA scores: opt: 539, E(): 3.9e-29, (34.3% identity
in 382 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0447c"
/db_xref="EnsemblGenomes-Tr:CCP43178"
/db_xref="GOA:O53732"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:O53732"
/protein_id="CCP43178.1"
/translation="MTVETSQTPSAAIDSDRWPAVAKVPRGPLAAASAAIANRLLRRT
ATHLPLRLVYSDGTATGAADPRAPSLFIHRPDALARRIGRHGLIGFGESYMAGEWSSK
ELTRVLTVLAGSVDELVPRSLHWLRPITPTFRPSWPDHSRDQARRNIAVHYDLSNDLF
AAFLDETMTYSCAMFTDLLAQPTPAWTELAAAQRRKIDRLLDVAGVQQGSHVLEIGTG
WGELCIRAAARGAHIRSVTLSVEQQRLARQRVAAAGFGHRVEIDLCDYRDVDGQYDSV
VSVEMIEAVGYRSWPRYFAALEQLVRPGGPVAIQAITMPHHRMLATRHTQTWIQKYIF
PGGLLPSTQAIIDITGQHTGLRIVDAASLRPHYAETLRLWRERFMQRRDGLAHLGFDE
VFARMWELYLAYSEAGFRSGYLDVYQWTLIREGPP"
gene complement(536504..537169)
/locus_tag="Rv0448c"
CDS complement(536504..537169)
/codon_start=1
/transl_table=11
/locus_tag="Rv0448c"
/product="Conserved hypothetical protein"
/note="Rv0448c, (MTV037.12c), len: 221 aa. Conserved
hypothetical protein, similar to other hypothetical
proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283
aa),FASTA scores: opt: 257, E(): 1.4e-10, (32.0% identity
in 197 aa overlap); etc. Some similarity to
U15183|MLU15183_38 from Mycobacterium leprae (82 aa),
FASTA scores: opt: 134,E(): 0.014, (71.0% identity in 31
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0448c"
/db_xref="EnsemblGenomes-Tr:CCP43179"
/db_xref="InterPro:IPR010775"
/db_xref="UniProtKB/TrEMBL:O53733"
/protein_id="CCP43179.1"
/translation="MHHSFAYRSYSWYVDVDNLPQLPWWLRPFARFHADDHFADPFSC
PPHSSLRDRLDAFFAARGLAVPDGRITALLQARVLGYVFNPLSIFWCHDRDGQLRHVI
AEVHNTYGGRHAYLLPPADLPVVTAKNFYVSPFHQLAGYYLIRAPRPDRELDVTVTLH
RDRRQVCPEFTATLRGQRRPATTRQIAMMQIISPLAPMVVAARIRIQGIRLWLRRVPV
VPR"
gene complement(537229..538548)
/locus_tag="Rv0449c"
CDS complement(537229..538548)
/codon_start=1
/transl_table=11
/locus_tag="Rv0449c"
/product="Conserved hypothetical protein"
/note="Rv0449c, (MTV037.13c), len: 439 aa. Conserved
hypothetical protein, some similarity with several
hypothetical proteins and various enzymes e.g.
AAK24569.1|AE005927 amine oxidase, flavin-containing from
Caulobacter crescentus (454 aa); BAB02771.1|AB023036
mycolic acid methyl transferase-like protein from
Arabidopsis thaliana (842 aa); BAB01742.1|AP000374 protein
which contains similarity to cyclopropane fatty acid
synthase from Arabidopsis thaliana (793 aa); etc. Has
hydrophobic stretch at N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0449c"
/db_xref="EnsemblGenomes-Tr:CCP43180"
/db_xref="GOA:O53734"
/db_xref="InterPro:IPR002937"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O53734"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43180.1"
/translation="MQQSLRRSVAVVGSGVAGLTAAYILSGRDRVTLYEADGRLGGHA
HTHYLDNGGGPRGTDVVGVDSAFLVHNDRTYPTLCRLFAELGVATQESEMSMSVRADD
IGLEYAGALGARGLFACRQSLRPRYLCMLAEILRFHRAAARLLREETDNAEDKPETLE
AFLSRHHFSQYFVDYFITPLVAAVWSCGGADALRYPARYLFVFLDHHGMLSVFGSPTW
RTVTGGSANYVQAIAAQLDEVSTRTPVHSLRRLPDGVLVGAGDGPSRRFDAAVVAVHP
DQALLLLDEPTPAERAVLGAIAYSTNSAQLHTDESVLPRHHRARASWNYLVTPGQHQV
VVSYDISRLMRLDGGRRYLVTLGGHDRVDPSSVIAEMTYSHPLYTPESVAAQRLLPTL
GDNRVVFAGAYHGWGFHEDGAASGLRAARRLGADWPAAIPQEAMVAC"
gene complement(538588..541491)
/gene="mmpL4"
/locus_tag="Rv0450c"
CDS complement(538588..541491)
/codon_start=1
/transl_table=11
/gene="mmpL4"
/locus_tag="Rv0450c"
/product="Probable conserved transmembrane transport
protein MmpL4"
/note="Rv0450c, (MTV037.14c), len: 967 aa. Probable
mmpL4,conserved transmembrane transport protein (see
citations below), member of RND superfamily, equivalent to
U1740V|P54881|YV34_MYCLE hypothetical 105.2 kDa protein
from Mycobacterium leprae (959 aa), FASTA scores: opt:
5051, E(): 0, (78.4% identity in 962 aa overlap). Also
highly similar to other proteins from Mycobacterium
tuberculosis e.g. Z83860|MTCY98.08 (962 aa), FASTA scores:
opt: 3917, E(): 0, (61.3% identity in 950 aa
overlap),MTCY20G9.34, etc. Contains PS00211 ABC
transporters family signature. Belongs to the MmpL
family."
/db_xref="EnsemblGenomes-Gn:Rv0450c"
/db_xref="EnsemblGenomes-Tr:CCP43181"
/db_xref="GOA:P9WJV3"
/db_xref="InterPro:IPR004707"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJV3"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43181.1"
/translation="MSTKFANDSNTNARPEKPFIARMIHAFAVPIILGWLAVCVVVTV
FVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFAMVIIEGNQPLGDAAH
KYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANE
SVEAVRSIVESTPAPPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLV
YRSIITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIF
IIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPYFQTLGIP
CAVGMLVAVAVALTLGPAVLHVGSRFGLFDPKRLLKVRGWRRVGTVVVRWPLPVLVAT
CAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYAAADRHFSQARMKPEILMIESDHD
MRNPADFLVLDKLAKGIFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIK
YQRDRANDMLKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHV
ADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDR
LMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDD
SFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEGIKSIDAIRTAAEES
LKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAISSLCLIFIIMLIITRAFIAAAV
IVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQE
IGAGLKTGIIRSMGGTGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTL
IVRSFMTPSIAALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG"
gene complement(541488..541910)
/gene="mmpS4"
/locus_tag="Rv0451c"
CDS complement(541488..541910)
/codon_start=1
/transl_table=11
/gene="mmpS4"
/locus_tag="Rv0451c"
/product="Probable conserved membrane protein MmpS4"
/note="Rv0451c, (MTV037.15c), len: 140 aa. Probable
mmpS4,conserved membrane protein (see citations
below),equivalent to U1740W|P54880|YV33_MYCLE hypothetical
16.9 kDa protein from Mycobacterium leprae (154 aa), FASTA
scores: opt: 727, E(): 0, (75.9% identity in 137 aa
overlap). Also similar to other Mycobacterial proteins
e.g. Z84725|MTCY04D9.16c from Mycobacterium tuberculosis
(142 aa), FASTA scores: opt: 451, E(): 3.2e-24, (50.0%
identity in 138 aa overlap); etc. Belongs to the MmpS
family. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004).
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0451c"
/db_xref="EnsemblGenomes-Tr:CCP43182"
/db_xref="GOA:P9WJS9"
/db_xref="InterPro:IPR008693"
/db_xref="InterPro:IPR038468"
/db_xref="PDB:2LW3"
/db_xref="UniProtKB/Swiss-Prot:P9WJS9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43182.1"
/translation="MLMRTWIPLVILVVVIVGGFTVHRIRGFFGSENRPSYSDTNLEN
SKPFNPKHLTYEIFGPPGTVADISYFDVNSEPQRVDGAVLPWSLHITTNDAAVMGNIV
AQGNSDSIGCRITVDGKVRAERVSNEVNAYTYCLVKSA"
gene 542142..542852
/locus_tag="Rv0452"
CDS 542142..542852
/codon_start=1
/transl_table=11
/locus_tag="Rv0452"
/product="Possible transcriptional regulatory protein"
/note="Rv0452, (MTV037.16), len: 236 aa. Possible
transcriptional regulator, similar to several putative
TetR-family transcriptional regulators from Streptomyces
coelicolor. Also similar in N-terminus to
U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67
aa), FASTA score: (76.1% identity in 67 aa overlap).
Contains probable helix-turn-helix motif at aa 44-65
(Score 1727, +5.07 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0452"
/db_xref="EnsemblGenomes-Tr:CCP43183"
/db_xref="GOA:O53737"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR041483"
/db_xref="UniProtKB/TrEMBL:O53737"
/protein_id="CCP43183.1"
/translation="MRYPLAVAQLGFQRARTEENKRQRAAALVEAARSLALETGVASV
TLTAVAGRAGIHYSAVRRYFTSHKEVLLHLAAEGWARWSGTVCEQLGEPGPMSAPRVA
EALANGLAADPLFCDLLANLHLHLEQEVDVDRVIEVKRTSIAAVIALVDAIESALPAL
GRSGAFDILLAAYSLAATLWQIANPPERLTDAYAEEPELLPPEWNLDFAAALTRLLTA
TLLGLLAGSPCECRSPTR"
gene 543174..544730
/gene="PPE11"
/locus_tag="Rv0453"
CDS 543174..544730
/codon_start=1
/transl_table=11
/gene="PPE11"
/locus_tag="Rv0453"
/product="PPE family protein PPE11"
/note="Rv0453, (MTV037.17), len: 518 aa. PPE11, Member of
the Mycobacterium tuberculosis PPE family, similar to many
e.g. AL0212|MTV012_32 from Mycobacterium tuberculosis (434
aa), FASTA scores: opt: 882, E(): 7e-31, (41.8% identity
in 514 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0453"
/db_xref="EnsemblGenomes-Tr:CCP43184"
/db_xref="GOA:P9WI39"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI39"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43184.1"
/translation="MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGREYAA
VAEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAAAARLEAVTAAYA
AALVAMPTLAELAANHATHGAMVATNFFGINTIPIAVNEADYVRMWLQAATTMATYQA
VADSAVRSIPDSVPPPRILKSNAQSQHSSSNNSGGADPVDDFIAEILKIITGGRVIWD
PEAGTVNGLPYDAYTNPGTLMWWIARSLELLQDFQEFAKLLFTNPVKAFQFLVDLILF
DWPTHMLQLATWLAENPQLLVAALTPAISGLGAVSGLAGLTGLVPQPPVVPAPAPDAV
VPTVLPLAGTATPTTAPASAPAAGAAPGPPAGTATATSASVPTSAGGFPPYLVGSGPG
IDFDAGTPAGSRRAQPAADNVTAVAAAQVSARHQARRRRRAAAKERGNADEFVDMDSG
PAIPPSGERDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRMPMLPGA
WDLGTWDRGD"
gene 544835..545185
/locus_tag="Rv0454"
CDS 544835..545185
/codon_start=1
/transl_table=11
/locus_tag="Rv0454"
/product="Conserved hypothetical protein"
/note="Rv0454, (MTV037.18), len: 116 aa (start uncertain).
Conserved hypothetical protein, showing similarity with
AAA63007.1|U15183 hypothetical protein from Mycobacterium
leprae (115 aa), FASTA scores: opt: 151, E():
0.0019,(31.5% identity in 89 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0454"
/db_xref="EnsemblGenomes-Tr:CCP43185"
/db_xref="UniProtKB/TrEMBL:O86364"
/protein_id="CCP43185.1"
/translation="MKQDFGLDVPQAGNAQNFDGVPEWVQVGVVTFVYRMQMHHVTRP
VGAPGSGLAGDSTPVQGRQRVWDLVAGRLTHAPRSSVQAMRPTMFTSAPQRHGIPARG
RWWLGYQERSRAWP"
gene complement(545375..545821)
/locus_tag="Rv0455c"
CDS complement(545375..545821)
/codon_start=1
/transl_table=11
/locus_tag="Rv0455c"
/product="Conserved protein"
/note="Rv0455c, (MTV037.19c), len: 148 aa. Conserved
protein, equivalent to CAC31896.1|AL583925 possible
secreted protein from Mycobacterium leprae (153 aa). Has
hydrophobic stretch at N-terminus. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004). Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0455c"
/db_xref="EnsemblGenomes-Tr:CCP43186"
/db_xref="GOA:O53740"
/db_xref="InterPro:IPR031702"
/db_xref="UniProtKB/TrEMBL:O53740"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43186.1"
/translation="MSRLSSILRAGAAFLVLGIAAATFPQSAAADSTEDFPIPRRMIA
TTCDAEQYLAAVRDTSPVYYQRYMIDFNNHANLQQATINKAHWFFSLSPAERRDYSEH
FYNGDPLTFAWVNHMKIFFNNKGVVAKGTEVCNGYPAGDMSVWNWA"
gene complement(545889..546803)
/gene="echA2"
/locus_tag="Rv0456c"
CDS complement(545889..546803)
/codon_start=1
/transl_table=11
/gene="echA2"
/locus_tag="Rv0456c"
/product="enoyl-CoA hydratase EchA2 (enoyl hydrase)
(unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv0456c, (MTCI429A.02, MTV037.20c), len: 304 aa.
Probable echA2, enoyl-CoA hydratase, similar to other
enoyl-CoA hydratases e.g. Q13011 peroxisomal enoyl-CoA
hydratase-like protein (328 aa), FASTA scores: opt:
209,E(): 5.3e-07, (31.7% identity in 142 aa overlap). Also
similar to several other proteins from Mycobacterium
tuberculosis e.g. MTCY09F9.29 FASTA score: (32.9% identity
in 146 aa overlap); and MTI376.01c."
/db_xref="EnsemblGenomes-Gn:Rv0456c"
/db_xref="EnsemblGenomes-Tr:CCP43187"
/db_xref="GOA:O07179"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:O07179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43187.1"
/translation="MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIG
LAERDQDIKVIVLRGAGRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTARETG
PTQKFMAIWRASKPVIAQVHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWGAYLT
GMWLYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATELARIPL
SQLQAQKLIVNQAYENMGLASTQLLGGILDGLMRNTPDALEFIRTAQTQGVRAAVERR
DGPFGDYSQAPPELRPDPTHVITPDGSM"
gene complement(547076..547357)
/gene="mazF1"
/gene_synonym="mt2"
/locus_tag="Rv0456A"
CDS complement(547076..547357)
/codon_start=1
/transl_table=11
/gene="mazF1"
/gene_synonym="mt2"
/locus_tag="Rv0456A"
/product="Possible toxin MazF1"
/note="Rv0456A, len: 93 aa. Possible mazF1, toxin, part of
toxin-antitoxin (TA) operon with Rv0456B (See Pandey and
Gerdes, 2005; Zhu et al., 2006); N-terminus highly similar
to N-terminal part of P71650|Rv2801c|MT2869|MTCY16B7.42
conserved hypothetical protein from Mycobacterium
tuberculosis (118 aa), FASTA scores: opt: 303, E():
1e-14,(60.44% identity in 91 aa overlap). Also some
similarity in part with other hypothetical proteins e.g.
Q9PHH8|XFA0027 Plasmid maintenance protein from Xylella
fastidiosa (108 aa), FASTA scores: opt: 169, E(): 3.9e-05,
(50.820% identity in 61 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0456A"
/db_xref="EnsemblGenomes-Tr:CCP43188"
/db_xref="GOA:Q6MX40"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="UniProtKB/Swiss-Prot:Q6MX40"
/protein_id="CCP43188.1"
/translation="MLRGEIWQVDLDPARGSAANMRRPAVIVSNDRANAAAIRLDRGV
VPVVPVTSNTEKVPIPGVVAGSERWPGRRFEGAGPAGWIRRCATSPLPS"
gene complement(547344..547517)
/gene="mazE1"
/locus_tag="Rv0456B"
CDS complement(547344..547517)
/codon_start=1
/transl_table=11
/gene="mazE1"
/locus_tag="Rv0456B"
/product="Possible antitoxin MazE1"
/note="Rv0456B, len: 57 aa. Possible mazE1, antitoxin,
part of toxin-antitoxin (TA) operon with Rv0456A (See
Pandey and Gerdes, 2005; Zhu et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv0456B"
/db_xref="EnsemblGenomes-Tr:CCP43189"
/db_xref="UniProtKB/Swiss-Prot:P0CL57"
/protein_id="CCP43189.1"
/translation="MTTYYYVLLSVTTWVGLRHEAKRELVYRGRRSIGRMPREWACRR
SRRFAANGVDAAR"
repeat_region complement(547488..547517)
/gene="mazE1"
/locus_tag="Rv0456B"
/note="3 copies of a 10 bp near-perfect direct
repeat,ATTACTACCTATTACTACGTATTACTATCT"
gene complement(547586..549607)
/locus_tag="Rv0457c"
CDS complement(547586..549607)
/codon_start=1
/transl_table=11
/locus_tag="Rv0457c"
/product="Probable peptidase"
/note="Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa.
Probable peptidase, similar to many e.g.
NP_102851.1|14022026|BAB48637.1 probable endopeptidase
from Mesorhizobium loti (687 aa); Y4NA_RHISN|P55577
probable peptidase (726 aa), FASTA scores: opt: 1126, E():
0, (40.9% identity in 491 aa overlap). Also similar to
Mycobacterium tuberculosis protein MTCY369.26 FASTA score:
(33.8% identity in 299 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0457c"
/db_xref="EnsemblGenomes-Tr:CCP43190"
/db_xref="GOA:O07178"
/db_xref="InterPro:IPR001375"
/db_xref="InterPro:IPR002470"
/db_xref="InterPro:IPR023302"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O07178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43190.1"
/translation="MTFEPAPDGADPYLWLEDVTGAEALDWVRARNKPTTAAFCDAEF
ERMRVEALEVLDTDARIPYVNRRGNYLYNFWRDAANPRGLWRRTTLDSYRTDSPGWDV
LIDVDELGRADDQKWVWGGAGVIEPDYTRALIGLSPGGSDASIVREFDMLTREFVEDG
FQLPPAKSQITWEDPDTVLLGTDFGGDSLTTSGYPRVIKRWRRGKPLADAETIFEGAG
TDVRVNASADRTPGFERTLLGRALDFWNEEVYELRGSELIRIEAPTDASVSIHRDWLL
IELRTDWTVATTRYTAGSLLAAEYDEFLAGSAELQVVFEPDEHTALYQYAWTRDRLLI
VTLADVASRVEIATPGSWRREPLSGIPAATNTVIVSADSHGDEFFLDSSGFDTPSRLM
RGTDDGRLAEIKSAPAFFDAENMAVTQYFATSDDGTSIPYFVVRRTDADNPGPTLLNG
YGGFETSRTPTYDGVLGRLWLARGGTYALANIRGGGEYGPGWHTQAMREGRDKVAQDF
AAVATDLVTRGITTAEQLGARGGSNGGLLMGIMLTGYPEKFGALVCDVPLLDMKRYHL
LLAGASWMAEYGDPDNPDDWKFISEYSPYQNISANRKYPPVLMTTSTRDDRVHPGHAR
KMTAALQAAGHPVWYYENIEGGHAGAADNAQIAFKSALSFAFLWRMLAG"
gene 549675..551198
/locus_tag="Rv0458"
CDS 549675..551198
/codon_start=1
/transl_table=11
/locus_tag="Rv0458"
/product="Probable aldehyde dehydrogenase"
/note="Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde
dehydrogenase, highly similar to many, closest to
P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase
from Rhodococcus erythropolis (506 aa), FASTA scores: opt:
2767, E(): 0, (79.7% identity in 507 aa overlap);
AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from
Xanthobacter autotrophicus (505 aa), FASTA scores: opt:
2563, E(): 0, (75.4% identity in 492 aa overlap);
Q9RJZ6|DHAL_STRCO probable aldehyde dehydrogenase from
Streptomyces coelicolor (507 aa). Also similar to other
semialdehyde dehydrogenases in Mycobacterium tuberculosis
e.g. Rv0768, Rv2858c. Belongs to the aldehyde
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0458"
/db_xref="EnsemblGenomes-Tr:CCP43191"
/db_xref="GOA:P9WNY1"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016160"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/Swiss-Prot:P9WNY1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43191.1"
/translation="MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVT
GQPFCEVPRSDAADIDKALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALAVA
EVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVG
QIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVN
GFGAEAGKPLASSDRIAKVAFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADV
LAAHDDFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDP
LDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFT
GTNNMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTAYRAGRDI
QAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKNLLVSYSDKALGFF"
gene 551198..551689
/locus_tag="Rv0459"
CDS 551198..551689
/codon_start=1
/transl_table=11
/locus_tag="Rv0459"
/product="Conserved hypothetical protein"
/note="Rv0459, (MTV038.03), len: 163 aa. Conserved
hypothetical protein, highly similar to other hypothetical
proteins. Note that highly similar to products of
unidentified ORFs in Xanthobacter autotrophicus,
AF029733_2 (139 aa), and Rhodococcus erythropolis, REREUTP
BC_1 (186 aa). Like MTV038.03, these ORF's are linked to
aldehyde dehydrogenase genes. FASTA scores:
AF0297|AF029733_2 (139 aa), opt: 439, E(): 6.2e-24, (50.0%
identity in 126 aa overlap); and L24492|REREUTPBC_1 (186
aa), opt: 347, E(): 2.1e-17, (52.7% identity in 169 aa
overlap). N-terminus also highly similar to
AAA63041.1|U15183 ethanolamine permease (eutP) match from
Mycobacterium leprae (53 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0459"
/db_xref="EnsemblGenomes-Tr:CCP43192"
/db_xref="InterPro:IPR008497"
/db_xref="UniProtKB/TrEMBL:O53744"
/protein_id="CCP43192.1"
/translation="MNAPAGVLITAEAAALLAGLQDRHGPVMFHQSGGCCDGSAPMCY
PRADFLVGDRDILLGVLDVGEDGVPVWISGPQYQAWKHTQLIIDVVPGRGGGFSLEAP
EGVRFLSRGRVFSDAEKAMREAAPVITGAAYECGERPLVRGLVVDLDDPDATPGVCRA
SRR"
gene 551749..551988
/locus_tag="Rv0460"
CDS 551749..551988
/codon_start=1
/transl_table=11
/locus_tag="Rv0460"
/product="Conserved hydrophobic protein"
/note="Rv0460, (MTV038.04), len: 79 aa. Conserved
hydrophobic protein, highly similar AAA63024.1|U15183
hypothetical protein from Mycobacterium leprae (56
aa),FASTA scores: opt: 197, E(): 3.7e-09, (63.8% identity
in 47 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0460"
/db_xref="EnsemblGenomes-Tr:CCP43193"
/db_xref="GOA:O53745"
/db_xref="InterPro:IPR031614"
/db_xref="UniProtKB/TrEMBL:O53745"
/protein_id="CCP43193.1"
/translation="MLVGNAIGLLAGVACSVLVHARIRPDIVIAMVVGIPSAIGLLVI
LFSGRRWVTMLGAFILALAPGWFGVLVAIQVASSG"
gene 552026..552550
/locus_tag="Rv0461"
CDS 552026..552550
/codon_start=1
/transl_table=11
/locus_tag="Rv0461"
/product="Probable transmembrane protein"
/note="Rv0461, (MTV038.05), len: 174 aa (start uncertain).
Probable transmembrane protein. Nucleotide position 552085
in the genome sequence has been corrected, A:G resulting
in Q20Q."
/db_xref="EnsemblGenomes-Gn:Rv0461"
/db_xref="EnsemblGenomes-Tr:CCP43194"
/db_xref="GOA:I6X961"
/db_xref="UniProtKB/TrEMBL:I6X961"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43194.1"
/translation="MPDFDTGAHSQRFLSLAGQQDRAGKSWPGSTPKPQEDPVGVAPS
ASVEVLGSEPAATLAHSVTVPGRYTYLKWWKFVLVVLGVWIGAGEVGLSLFYWWYHTL
DKTAAVFVVLVYVVACTVGGLILALVPGRPLITALSLGVMSGPFASVAAAAPLYGYYY
CERMSHCLVGVIPY"
gene 552614..554008
/gene="lpdC"
/gene_synonym="CIP50"
/gene_synonym="TB49.2"
/locus_tag="Rv0462"
CDS 552614..554008
/codon_start=1
/transl_table=11
/gene="lpdC"
/gene_synonym="CIP50"
/gene_synonym="TB49.2"
/locus_tag="Rv0462"
/product="Dihydrolipoamide dehydrogenase LpdC (lipoamide
reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl
dehydrogenase) (diaphorase)"
/note="Rv0462, (MTV038.06), len: 464 aa. LpdC (alternate
gene name: TB49.2, CIP50), dihydrolipoamide dehydrogenase
(see Argyrou & Blanchard 2001), equivalent to
AAA63016.1|U15183 lipoamide dehydrogenase from
Mycobacterium leprae (467 aa), FASTA scores: opt:
2583,E(): 0, (83.1% identity in 467 aa overlap). Also
similar to to many e.g. P50970|DLDH_ZYMMO|X82291|ZMLPD_1
dihydrolipoamide dehydrogenase from Z.mobilis (466
aa),FASTA scores: opt: 1198, E(): 0, (42.4 % identity in
465 aa overlap); etc. Belongs to the pyridine
nucleotide-disulfide oxidoreductases class-I. Binds to
coronin-1 in BCG and M. tuberculosis - coronin-1 is
retained on phagosomes and phagosome maturation is
arrested (See Deghmane et al.,2007). LpdC|Rv0462
co-immunoprecipitates with DlaT|Rv2215 (in lpdC|Rv0462
mutant) and with BkdC|Rv2495c (in dlaT|Rv2215 mutant) (See
Venugopal et al., 2011)."
/db_xref="EnsemblGenomes-Gn:Rv0462"
/db_xref="EnsemblGenomes-Tr:CCP43195"
/db_xref="GOA:P9WHH9"
/db_xref="InterPro:IPR001100"
/db_xref="InterPro:IPR004099"
/db_xref="InterPro:IPR006258"
/db_xref="InterPro:IPR012999"
/db_xref="InterPro:IPR016156"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="PDB:2A8X"
/db_xref="PDB:3II4"
/db_xref="PDB:4M52"
/db_xref="UniProtKB/Swiss-Prot:P9WHH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43195.1"
/translation="MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNV
GCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMK
KNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVT
YEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEI
EKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGY
GLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGA
ETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPS
GFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEAL
QECFHGLVGHMINF"
gene 554016..554309
/locus_tag="Rv0463"
CDS 554016..554309
/codon_start=1
/transl_table=11
/locus_tag="Rv0463"
/product="Probable conserved membrane protein"
/note="Rv0463, (MTV038.07), len: 97 aa. Probable conserved
transmembrane protein, highly similar to AAA63017.1|U15183
hypothetical protein from Mycobacterium leprae (101
aa),FASTA scores: opt: 364, E(): 4e-21, (57.9% identity in
95 aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0463"
/db_xref="EnsemblGenomes-Tr:CCP43196"
/db_xref="GOA:O53748"
/db_xref="UniProtKB/TrEMBL:O53748"
/protein_id="CCP43196.1"
/translation="MTRRASTDTPQIIMGAIGGVVTGYILWLAAISVGDGLTTVSQWS
RVVLLLSVLVAVCGAAGGLRLRSRGKLAWSAFAFSLPIPPVVLTVAVLADIYL"
gene complement(554313..554885)
/locus_tag="Rv0464c"
CDS complement(554313..554885)
/codon_start=1
/transl_table=11
/locus_tag="Rv0464c"
/product="Conserved protein"
/note="Rv0464c, (MTV038.08c), len: 190 aa. Conserved
protein, highly similar to CAC31982.1|AL583925 conserved
hypothetical protein from Mycobacterium leprae (188 aa).
Also some similarity with Rv1531|AL022000|MTV045_5|D70820
hypothetical protein from Mycobacterium tuberculosis (188
aa), FASTA scores: E(): 9.6e-10, (30.9% identity in 175 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0464c"
/db_xref="EnsemblGenomes-Tr:CCP43197"
/db_xref="GOA:O53749"
/db_xref="InterPro:IPR003779"
/db_xref="InterPro:IPR029032"
/db_xref="UniProtKB/TrEMBL:O53749"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43197.1"
/translation="MTGQNGQVARISPGKFRQLGPVNWLVAKLAARAVGAPQMHLFTT
LGYRQYLFWTFAIYTGRLLHGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLD
ANTQATIFAWPDVPDGDGPRKVLSARQQALLQATDELIKDRTITAGTWERLATHLDPR
LLIEFCLLATQYDAIAATITALAIPPDNPQ"
gene complement(554882..556306)
/locus_tag="Rv0465c"
CDS complement(554882..556306)
/codon_start=1
/transl_table=11
/locus_tag="Rv0465c"
/product="Probable transcriptional regulatory protein"
/note="Rv0465c, (MTV038.09c), len: 474 aa. Probable
transcriptional regulator, highly similar to
AC44331.1|AL596102 putative DNA-binding protein from
Streptomyces coelicolor (489 aa); and similar to several
hypothetical proteins and others transcriptional
regulators. Some similarity in N-terminal region (1-100
aa) with repressors e.g. P06153|RPC_BPPH1 immunity
repressor protein (144 aa), FASTA scores: opt: 130, E():
0.084,(27.0% identity in 100 aa overlap). Very similar to
Rv1129c|Z95585|MTCY22G8.18c from Mycobacterium
tuberculosis (486 aa), FASTA scores: opt: 1475, E(): 0,
(47.4% identity in 468 aa overlap). Contains probable
helix-turn-helix motif at aa 19-40 (1827, +5.41 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0465c"
/db_xref="EnsemblGenomes-Tr:CCP43198"
/db_xref="GOA:P9WMI1"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010359"
/db_xref="InterPro:IPR010982"
/db_xref="InterPro:IPR018653"
/db_xref="InterPro:IPR026281"
/db_xref="UniProtKB/Swiss-Prot:P9WMI1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43198.1"
/translation="MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRP
LTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHP
GLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHAL
DTAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEIS
SHLSPGQQVFKMAAELAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLP
YRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMS
KRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAAR
YGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAF
PALGRALDLDEHRSTVSPYLVKQL"
gene 556458..557252
/locus_tag="Rv0466"
CDS 556458..557252
/codon_start=1
/transl_table=11
/locus_tag="Rv0466"
/product="Conserved protein"
/note="Rv0466, (MTV038.10), len: 264 aa. Conserved
protein,equivalent to CAC31980.1|AL583925 conserved
hypothetical protein from Mycobacterium leprae (264 aa).
Similar to Rv2001|Z74025|MTCY39.17c hypothetical 28.7 KDA
protein from Mycobacterium tuberculosis (250 aa), FASTA
scores: opt: 592, E(): 0, (38.0% identity in 263 aa
overlap). Some similarity to several thioesterases e.g.
Q42561|ATACPTE17_1 acyl-(acyl carrier protein) thioester
from A. thaliana (362 aa), FASTA scores: E(): 0.0092,
(24.4% identity in 197 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0466"
/db_xref="EnsemblGenomes-Tr:CCP43199"
/db_xref="GOA:O53751"
/db_xref="InterPro:IPR002864"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:O53751"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43199.1"
/translation="MSLDKKLMPVPDGHPDVFDREWPLRVGDIDRAGRLRLDAACRHI
QDIGQDQLREMGFEETHPLWIVRRTMVDLIRPIEFGDMLRCRRWCSGTSNRWCEMRVR
VDGRKGGLIESEAFWIHVNRETEMPARIADDFLAGLHRTTSVDRLRWKGYLKPGSRDD
ASEIHEFPVRVTDIDLFDHMNNAVYWSVIEDYLASHAELLRGPLRVTIEHEAPVALGD
KLEIISHVHPAGSTEIFGPGLVDRAVTTLTYVVGDEPKAVASLFNL"
gene 557527..558813
/gene="icl1"
/gene_synonym="aceA"
/gene_synonym="icl"
/locus_tag="Rv0467"
CDS 557527..558813
/codon_start=1
/transl_table=11
/gene="icl1"
/gene_synonym="aceA"
/gene_synonym="icl"
/locus_tag="Rv0467"
/product="Isocitrate lyase Icl (isocitrase)
(isocitratase)"
/note="Rv0467, (MTV038.11), len: 428 aa. Icl1, isocitrate
lyase (see citations below), highly similar to
many,closest to Z29367|RFISCILY_1 from R. fascians (429
aa),FASTA scores: opt: 2359, E(): 0, (80.7% identity in
429 aa overlap). Belongs to the isocitrate lyase family.
Has 2-methyl-isocitrate lyase (MCL) activity in M.
tuberculosis Erdman (See Munoz-Elias et al., 2006; Gould
et al., 2006). Predicted possible vaccine candidate (See
Zvi et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0467"
/db_xref="EnsemblGenomes-Tr:CCP43200"
/db_xref="GOA:P9WKK7"
/db_xref="InterPro:IPR006254"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR018523"
/db_xref="InterPro:IPR040442"
/db_xref="PDB:1F61"
/db_xref="PDB:1F8I"
/db_xref="PDB:1F8M"
/db_xref="PDB:5DQL"
/db_xref="UniProtKB/Swiss-Prot:P9WKK7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43200.1"
/translation="MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVE
EHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLS
GHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGG
ALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADV
ADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYA
PFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQK
ELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATK
HQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH"
gene 558895..559755
/gene="fadB2"
/locus_tag="Rv0468"
CDS 558895..559755
/codon_start=1
/transl_table=11
/gene="fadB2"
/locus_tag="Rv0468"
/product="3-hydroxybutyryl-CoA dehydrogenase FadB2
(beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)"
/note="Rv0468, (MTV038.12), len: 286 aa.
fadB2,3-hydroxybutyryl-CoA dehydrogenase, equivalent to
CAC31978.1|AL583925 3-hydroxyacyl-CoA dehydrogenase from
Mycobacterium leprae (287 aa). Also similar to many
3-hydroxybutyryl-CoA dehydrogenases e.g. U32229|BJU32229_1
beta-hydroxybutyryl coenzyme A dehydrogenase from
Bradyrhizobium japonicum (293 aa), FASTA scores: opt:
771,E(): 0, (45.7% identity in 282 aa overlap). Belongs to
the 3-hydroxyacyl-CoA dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv0468"
/db_xref="EnsemblGenomes-Tr:CCP43201"
/db_xref="GOA:P9WNP7"
/db_xref="InterPro:IPR006108"
/db_xref="InterPro:IPR006176"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR022694"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:6HRD"
/db_xref="UniProtKB/Swiss-Prot:P9WNP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43201.1"
/translation="MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAG
RNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEI
FAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTL
VTDEAAAARTEEFASTVLGKQVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDV
DKAVVAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLG
KKSGRGFYTY"
gene 559888..560748
/gene="umaA"
/gene_synonym="umaA1"
/locus_tag="Rv0469"
CDS 559888..560748
/codon_start=1
/transl_table=11
/gene="umaA"
/gene_synonym="umaA1"
/locus_tag="Rv0469"
/product="Possible mycolic acid synthase UmaA"
/note="Rv0469, (MTV038.13), len: 286 aa. Possible
umaA,mycolic acid synthase (see citations below), highly
similar to CAC30854.1|AL583923 methyl mycolic acid
synthase 1 from Mycobacterium leprae (286 aa); and
CAC31976.1|AL583925 Mycolic acid synthase from
Mycobacterium leprae (295 aa),FASTA scores: opt: 1402,
E(): 0, (69.6% identity in 286 aa overlap). Also very
similar to mycobacterial methyltransferases e.g.
U77466|CmaD|MBU77466_1 (286 aa);
MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar
to CFA1_MYCTU|Q11195|U66108|MTU66108_1
cyclopropane-fatty-acyl-phospholipid synthase 1 (287
aa),FASTA scores: opt: 1360, E(): 0, (67.8% identity in
286 aa overlap) (see citation below); and very similar
also to methoxy mycolic acid synthase 1 from Mycobacterium
tuberculosis e.g. MTU66108_1 (286 aa). Note that
previously known as umaA1."
/db_xref="EnsemblGenomes-Gn:Rv0469"
/db_xref="EnsemblGenomes-Tr:CCP43202"
/db_xref="GOA:Q6MX39"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:Q6MX39"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43202.1"
/translation="MTELRPFYEESQSIYDVSDEFFSLFLDPTMAYTCAYFEREDMTL
EEAQNAKFDLALDKLHLEPGMTLLDIGCGWGGGLQRAIENYDVNVIGITLSRNQFEYS
KAKLAKIPTERSVQVRLQGWDEFTDKVDRIVSIGAFEAFKMERYAAFFERSYDILPDD
GRMLLHTILTYTQKQMHEMGVKVTMSDVRFMKFIGEEIFPGGQLPAQEDIFKFAQAAD
FSVEKVQLLQQHYARTLNIWAANLEANKDRAIALQSEEIYNKYMHYLTGCEHFFRKGI
SNVGQFTLTK"
gene complement(560848..561711)
/gene="pcaA"
/gene_synonym="umaA2"
/locus_tag="Rv0470c"
CDS complement(560848..561711)
/codon_start=1
/transl_table=11
/gene="pcaA"
/gene_synonym="umaA2"
/locus_tag="Rv0470c"
/product="Mycolic acid synthase PcaA (cyclopropane
synthase)"
/note="Rv0470c, (MTV038.14), len: 287 aa. PcaA (previously
known as umaA2), mycolic acid synthase (cyclopropane
synthase) (see citations below), equivalent to
CAC31976.1|AL583925 Mycolic acid synthase from
Mycobacterium leprae (295 aa); and highly similar to
S72886|B2168_F3_130|467038|AAA17222.1|U00018 hypothetical
protein from Mycobacterium leprae (308 aa);
Q11195|CFA1_MYCTU cyclopropane-fatty-acyl-phospholipid
synthase 1 (cyclopropane mycolic acid synthase 1) (287 aa)
(see Glickman et al., 2000); U27357|MTU27357_1
cyclopropane mycolic acid synthase from Mycobacterium
tuberculosis (287 aa), FASTA scores: opt: 1415, E(): 0,
(72.8% identity in 287 aa overlap); and related enzymes
e.g. MTCY20H10.25c|Z92772|MTY20H10_26 (287 aa), FASTA
scores: opt: 1387, E(): 0, (72.5% identity in 287 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0470c"
/db_xref="EnsemblGenomes-Tr:CCP43203"
/db_xref="GOA:P9WPB3"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:1L1E"
/db_xref="UniProtKB/Swiss-Prot:P9WPB3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43203.1"
/translation="MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
LQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAGH
VQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGHQRYHHFFEVTHRTLPA
DGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKFILAEIFPGGWLPSIPTVHEYAEKV
GFRVTAVQSLQLHYARTLDMWATALEANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQG
YTDVDQFTLEK"
gene complement(561854..562294)
/locus_tag="Rv0470A"
CDS complement(561854..562294)
/codon_start=1
/transl_table=11
/locus_tag="Rv0470A"
/product="Hypothetical protein"
/note="Rv0470A, len: 146 aa. Hypothetical unknown protein.
GC plot suggests CDS for Cys-rich protein, could possibly
be continuation of Rv0471c but no frameshift found to
allow this. Sequence same in Mycobacterium bovis and
Mycobacterium tuberculosis strain CDC1551. Weak hits to
Cys-rich region (aa 258-314) of D63395|D63395_1 mRNA for
NOTCH4 from Homo sapiens (1095 aa), FASTA scores: opt:
132,E(): 1.1, (39.35% identity in 61 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0470A"
/db_xref="EnsemblGenomes-Tr:CCP43204"
/db_xref="GOA:L7N651"
/db_xref="UniProtKB/TrEMBL:L7N651"
/protein_id="CCP43204.1"
/translation="MGAGGWEVVLASLPYGLLCTTVLMGKHIDKIGYDEPLGIRTLPV
LLGETCARTVTLAMMVGFYLLIAVNVMLAAMPWPRCWSPGRCPGWRKCGPISCDGGPS
SRHRRFRCGRCGMPRWPGCTCVRPVRCWLWAWRSVPGGAPGDFR"
gene complement(562225..562713)
/locus_tag="Rv0471c"
CDS complement(562225..562713)
/codon_start=1
/transl_table=11
/locus_tag="Rv0471c"
/product="Hypothetical protein"
/note="Rv0471c, (MTV038.15c), len: 162 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0471c"
/db_xref="EnsemblGenomes-Tr:CCP43205"
/db_xref="UniProtKB/TrEMBL:O53756"
/protein_id="CCP43205.1"
/translation="MPDAGAGSRLRSWAYALRTTNPPADGPTDTVTRWLVVTRAAVLP
MTLVSGLVAGLLAIGEPGLDWRWLVLWWESHAPHIANNLMNDLYDTDVGTDSATYARA
RYAQHPAATGANRAAYTTPRRTTSCGSPERALEPTTPRWARAVGRSCWRRSPTGCCAP
RC"
gene complement(562723..563427)
/locus_tag="Rv0472c"
CDS complement(562723..563427)
/codon_start=1
/transl_table=11
/locus_tag="Rv0472c"
/product="Probable transcriptional regulatory protein
(possibly TetR-family)"
/note="Rv0472c, (MTV038.16c), len: 234 aa. Probable
regulatory protein, possibly TetR family, equivalent to
CAC31974.1|AL583925 possible TetR-family transcriptional
regulator from Mycobacterium leprae (233 aa). Also similar
to CAC01492.1|AL391017 putative transcriptional regulatory
protein from Streptomyces coelicolor (218 aa); and
CAC01371.1|AL390975 putative TetR-family transcriptional
regulator from Streptomyces coelicolor (228 aa). Also
similar to AL0212|MTV012_65 from Mycobacterium
tuberculosis (246 aa), FASTA scores: opt: 327, E():
1.8e-15, (31.0% identity in 232 aa overlap); and
Z95120|MTCY07D11.18c (228 aa), FASTA scores: opt: 190,
E(): 4.4e-06, (23.1% identity in 186 aa overlap). Contains
probable helix-turn-helix doimain at aa 45-66 (Score 1429,
+4.05 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0472c"
/db_xref="EnsemblGenomes-Tr:CCP43206"
/db_xref="GOA:P9WMD9"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/Swiss-Prot:P9WMD9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43206.1"
/translation="MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHGRF
LSMDEIAAEIGVSKTVLYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGFELT
REIIRVYVETVAAQPEPYRFVMANSSASKSKVIADSERIIARMLAVMLRRRMQEAGMD
TGGVEPWAYLIVGGVQLATHSWMSDPRMSSDELIDYLTMLSWSALCGIVEAGGSLEKF
REQPHPSPIVPAWGQV"
gene 563564..564934
/locus_tag="Rv0473"
CDS 563564..564934
/codon_start=1
/transl_table=11
/locus_tag="Rv0473"
/product="Possible conserved transmembrane protein"
/note="Rv0473, (MTV038.17), len: 456 aa. Possible
conserved transmembrane protein, showing some similarity
to hypothetical proteins e.g.
NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical
protein from Mesorhizobium loti (431 aa);
P39385|YJIN_ECOLI|YJIN|B4336 hypothetical 48.2 kDa protein
(potential integral membrane protein) from Escherichia
coli strain K12 (426 aa), FASTA scores: opt: 396, E():
9.8e-19,(31.8 % identity in 424 aa overlap); etc.
Nucleotide position 563577 in the genome sequence has been
corrected,A:G resulting in K5R."
/db_xref="EnsemblGenomes-Gn:Rv0473"
/db_xref="EnsemblGenomes-Tr:CCP43207"
/db_xref="GOA:I6Y3V3"
/db_xref="InterPro:IPR007383"
/db_xref="UniProtKB/TrEMBL:I6Y3V3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43207.1"
/translation="MVAHRAEVSGSPPPRLNLSTQPTVARRVRASFAESFAAADPEAD
AARRMALRRMKVVAVGFLVGATGVFLACRWAQADGADHAWLGYLGAAAEAGMVGALAD
WFAVTALFKHPLGIPIPHTAIIKRKKDQLGEGLGTFVRENFLSPPVVETKLRDAQIPS
RLGKWLSEATHAQRVAAETATVLRVLVELLRDEDIQQVIDRMIVRRIAEPQWGPPAGR
VLATLLAENRQEAFIQLLADRAFQWSLNAGVVIQRVVERDSPSWSPRFIDHLVGDRIH
RELMEFTDKVRRNPDHELRRSATRFLFDFADDLQHDPATVARADAIKEELMARDEIAT
AAAAAWKTLKRLVLEGVDDPSSALRTRITDAVIRIGESLRDDADLRDKVDSWTVRAAQ
HLVSEYGVEITAIITETIERWDAEEASRRIELHVGRDLQFIRINGTVVGAMAGLAIYA
IAQLLF"
gene 565021..565443
/locus_tag="Rv0474"
CDS 565021..565443
/codon_start=1
/transl_table=11
/locus_tag="Rv0474"
/product="Probable transcriptional regulatory protein"
/note="Rv0474, (MTV038.18), len: 140 aa. Probable
transcriptional regulator, highly similar to others e.g.
CAC04034.1|AL391406 putative DNA-binding protein from
Streptomyces coelicolor (141 aa); N-terminus of
NP_104173.1|14023352|BAB49959.1|AP003000 transcriptional
regulator from Mesorhizobium loti (219 aa); N-terminus of
A83618|PA0225 probable transcription regulator from
Pseudomonas aeruginosa (179 aa); SINR_BACSU|P06533 sinr
protein from Bacillus subtilis (111 aa), FASTA scores:
opt: 147, E(): 8.9e-06, (30.6% identity in 111 aa
overlap). Also similar to other hypothetical proteins e.g.
X66407|RRPHAS_1|ORF1 from Rhodococcus ruber (171 aa),
FASTA scores: opt: 280, E(): 4.8e-12, (43.6% identity in
117 aa overlap). Also similar to Rv2745c from
Mycobacterium tuberculosis. Contains probable
helix-turn-helix domain at aa 35-56 (Score 1709, +5.01
SD)."
/db_xref="EnsemblGenomes-Gn:Rv0474"
/db_xref="EnsemblGenomes-Tr:CCP43208"
/db_xref="GOA:P9WMH9"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010982"
/db_xref="UniProtKB/Swiss-Prot:P9WMH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43208.1"
/translation="MSSEEKLAAKVSTKASDVASDIGSFIRSQRETAHVSMRQLAERS
GVSNPYLSQVERGLRKPSADVLSQIAKALRVSAEVLYVRAGILEPSETSQVRDAIITD
TAITERQKQILLDIYASFTHQNEATREECPSDPTPTDD"
gene 565797..566396
/gene="hbhA"
/locus_tag="Rv0475"
CDS 565797..566396
/codon_start=1
/transl_table=11
/gene="hbhA"
/locus_tag="Rv0475"
/product="Iron-regulated heparin binding hemagglutinin
HbhA (adhesin)"
/note="Rv0475, hbhA (MTCY20G9.01), len: 199 aa.
HbhA,iron-regulated heparin-binding hemagglutinin (see
citations below), equivalent to CAC31971.1|AL583925
possible hemagglutinin from Mycobacterium leprae (188 aa).
Contains possible N-terminal signal sequence and K-a-rich
region at C-terminus: subcellular location: surface
associated. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0475"
/db_xref="EnsemblGenomes-Tr:CCP43209"
/db_xref="GOA:P9WIP9"
/db_xref="UniProtKB/Swiss-Prot:P9WIP9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43209.1"
/translation="MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRT
DTRSRVEESRARLTKLQEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERG
EAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELP
KKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK"
gene 566508..566771
/locus_tag="Rv0476"
CDS 566508..566771
/codon_start=1
/transl_table=11
/locus_tag="Rv0476"
/product="Possible conserved transmembrane protein"
/note="Rv0476, (MTCY20G9.02), len: 87 aa. Possible
conserved transmembrane protein, equivalent to
CAC31970.1|AL583925 conserved membrane protein from
Mycobacterium leprae (95 aa). Also highly similar to
CAC04036.1|AL391406 putative membrane protein from
Streptomyces coelicolor (113 aa). Contains PS00606
Beta-ketoacyl synthases active site."
/db_xref="EnsemblGenomes-Gn:Rv0476"
/db_xref="EnsemblGenomes-Tr:CCP43210"
/db_xref="GOA:P9WKW1"
/db_xref="InterPro:IPR019662"
/db_xref="UniProtKB/Swiss-Prot:P9WKW1"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43210.1"
/translation="MLVLLVAVLVTAVYAFVHAALQRPDAYTAADKLTKPVWLVILGA
AVALASILYPVLGVLGMAMSACASGVYLVDVRPKLLEIQGKSR"
gene 566776..567222
/locus_tag="Rv0477"
CDS 566776..567222
/codon_start=1
/transl_table=11
/locus_tag="Rv0477"
/product="Possible conserved secreted protein"
/note="Rv0477, (MTCY20G9.03), len: 148 aa. Possible
conserved secreted protein, equivalent to
CAC31969.1|AL583925 hypothetical protein from
Mycobacterium leprae (123 aa). Also similar to
G83406|PA1914 conserved hypothetical protein from
Pseudomonas aeruginosa (408 aa). Contains possible
N-terminal signal sequence. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004)."
/db_xref="EnsemblGenomes-Gn:Rv0477"
/db_xref="EnsemblGenomes-Tr:CCP43211"
/db_xref="GOA:P9WKV9"
/db_xref="InterPro:IPR019719"
/db_xref="UniProtKB/Swiss-Prot:P9WKV9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43211.1"
/translation="MKALVAVSAVAVVALLGVSSAQADPEADPGAGEANYGGPPSSPR
LVDHTEWAQWGSLPSLRVYPSQVGRTASRRLGMAAADAAWAEVLALSPEADTAGMRAQ
FICHWQYAEIRQPGKPSWNLEPWRPVVDDSEMLASGCNPGSPEESF"
gene 567222..567896
/gene="deoC"
/locus_tag="Rv0478"
CDS 567222..567896
/codon_start=1
/transl_table=11
/gene="deoC"
/locus_tag="Rv0478"
/product="Probable deoxyribose-phosphate aldolase DeoC
(phosphodeoxyriboaldolase) (deoxyriboaldolase)"
/note="Rv0478, (MTCY20G9.04), len: 224 aa. Probable
deoC,deoxyribose-phosphate aldolase, equivalent to
Q9CB45|DEOC_MYCLE deoxyribose-phosphate aldolase from
Mycobacterium leprae (226 aa). Also highly similar to
others e.g. DEOC_BACSU|P39121 from Bacillus subtilis (214
aa), FASTA scores: opt: 543, E(): 1.4e-26, (45.9% identity
in 209 aa overlap); etc. Belongs to the DEOC/FBAB family
of aldolases, DEOC subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0478"
/db_xref="EnsemblGenomes-Tr:CCP43212"
/db_xref="GOA:P9WP03"
/db_xref="InterPro:IPR002915"
/db_xref="InterPro:IPR011343"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR028581"
/db_xref="UniProtKB/Swiss-Prot:P9WP03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43212.1"
/translation="MLGQPTRAQLAALVDHTLLKPETTRADVAALVAEAAELGVYAVC
VSPSMVPVAVQAGGVRVAAVTGFPSGKHVSSVKAHEAAAALASGASEIDMVIDIGAAL
CGDIDAVRSDIEAVRAAAAGAVLKVIVESAVLLGQSNAHTLVDACRAAEDAGADFVKT
STGCHPAGGATVRAVELMAETVGPRLGVKASGGIRTAADAVAMLNAGATRLGLSGTRA
VLDGLS"
gene complement(567921..568967)
/locus_tag="Rv0479c"
CDS complement(567921..568967)
/codon_start=1
/transl_table=11
/locus_tag="Rv0479c"
/product="Probable conserved membrane protein"
/note="Rv0479c, (MTCY20G9.04c), len: 348 aa. Probable
conserved membrane protein, equivalent to
CAC31967.1|AL583925 possible secreted protein from
Mycobacterium leprae (254 aa); and C-terminus highly
similar to AAF74996.1|AF143402_1|AF143402 putative
multicopper oxidase from Mycobacterium avium (149 aa).
Contains hydrophobic domain in centre of protein. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0479c"
/db_xref="EnsemblGenomes-Tr:CCP43213"
/db_xref="GOA:P9WKV7"
/db_xref="InterPro:IPR021373"
/db_xref="UniProtKB/Swiss-Prot:P9WKV7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43213.1"
/translation="MTNPQGPPNDPSPWARPGDQGPLARPPASSEASTGRLRPGEPAG
HIQEPVSPPTQPEQQPQTEHLAASHAHTRRSGRQAAHQAWDPTGLLAAQEEEPAAVKT
KRRARRDPLTVFLVLIIVFSLVLAGLIGGELYARHVANSKVAQAVACVVKDQATASFG
VAPLLLWQVATRHFTNISVETAGNQIRDAKGMQIKLTIQNVRLKNTPNSRGTIGALDA
TITWSSEGIKESVQNAIPILGAFVTSSVVTHPADGTVELKGLLNNITAKPIVAGKGLE
LQIINFNTLGFSLPKETVQSTLNEFTSSLTKNYPLGIHADSVQVTSTGVVSRFSTRDA
AIPTGIQNPCFSHI"
gene complement(568964..569806)
/locus_tag="Rv0480c"
CDS complement(568964..569806)
/codon_start=1
/transl_table=11
/locus_tag="Rv0480c"
/product="Possible amidohydrolase"
/note="Rv0480c, (MTCY20G9.06c), len: 280 aa. Possible
amidohydrolase, highly similar to
NP_302587.1|NC_002677|CAC31966.1|AL583925 putative
hydrolase from Mycobacterium leprae (271 aa). Also similar
to other hydrolases and hypothetical proteins e.g.
NP_601985.1|NC_003450 Predicted amidohydrolase from
Corynebacterium glutamicum (266 aa); NP_459623.1|NC_003197
putative hydrolase from Salmonella typhimurium LT2 (262
aa); AL096822|SCGD3_8|NP_627996.1|NC_003888 probable
hydrolase from Streptomyces coelicolor (264 aa), FASTA
scores: opt: 368, E(): 6.1e-15, (34.2% identity in 272 aa
overlap); YAUB_SCHPO|Q10166 hypothetical 35.7 kDa protein
c26a3.11 from S. pombe (322 aa), FASTA scores: opt:
338,E():1.4e-13, (30.3% identity in 277 aa overlap); etc.
Start changed since first submission (-60 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0480c"
/db_xref="EnsemblGenomes-Tr:CCP43214"
/db_xref="GOA:P9WJ01"
/db_xref="InterPro:IPR001110"
/db_xref="InterPro:IPR003010"
/db_xref="InterPro:IPR036526"
/db_xref="UniProtKB/Swiss-Prot:P9WJ01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43214.1"
/translation="MRIALAQIRSGTDPAANLQLVGKYAGEAATAGAQLVVFPEATMC
RLGVPLRQVAEPVDGPWANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPN
QPDAHYHKIHLYDAFGFTESRTVAPGREPVVVVVDGVRVGLTVCYDIRFPALYTELAR
RGAQLIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGDARTGVGASSAA
PTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAAARDRIAVLRNQTDFVQIDKA
QSRG"
gene complement(569988..570512)
/locus_tag="Rv0481c"
CDS complement(569988..570512)
/codon_start=1
/transl_table=11
/locus_tag="Rv0481c"
/product="Hypothetical protein"
/note="Rv0481c, (MTCY20G9.07c), len: 174 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0481c"
/db_xref="EnsemblGenomes-Tr:CCP43215"
/db_xref="GOA:P9WKV5"
/db_xref="InterPro:IPR019639"
/db_xref="UniProtKB/Swiss-Prot:P9WKV5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43215.1"
/translation="MPRSFDMSADYEGSVEEVHRAFYEADYWKARLAETPVDVATLES
IRVGGDSGDDGTIEVVTLQMVRSHNLPGLVTQLHRGDLSVRREETWGPVKEGIATASI
AGSIVDAPVNLWGTAVLSPIPESGGSRMTLQVTIQVRIPFIGGKLERLIGTQLSQLVT
IEQRFTTLWITNNV"
gene 570539..571648
/gene="murB"
/locus_tag="Rv0482"
CDS 570539..571648
/codon_start=1
/transl_table=11
/gene="murB"
/locus_tag="Rv0482"
/product="Probable UDP-N-acetylenolpyruvoylglucosamine
reductase MurB (UDP-N-acetylmuramate dehydrogenase)"
/note="Rv0482, (MTCY20G9.08), len: 369 aa. Probable
murB,UDP-N-acetylenolpyruvoylglucosamine reductase (see
citation below), equivalent to CAC31964.1|AL583925
UDP-N-acetylenolpyruvoylglucosamine reductase from
Mycobacterium leprae (367 aa). Also highly similar to
others e.g. MURB_ECOLI|P08373
UDP-N-acetylenolpyruvoylglucosamine reductase from
Escherichia coli (342 aa), FASTA scores: opt: 292, E():
6.3e-12, (33.5% identity in 355 aa overlap); etc. Belongs
to the MurB family. Cofactor: FAD."
/db_xref="EnsemblGenomes-Gn:Rv0482"
/db_xref="EnsemblGenomes-Tr:CCP43216"
/db_xref="GOA:P9WJL9"
/db_xref="InterPro:IPR003170"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR011601"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016167"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="InterPro:IPR036635"
/db_xref="PDB:5JZX"
/db_xref="UniProtKB/Swiss-Prot:P9WJL9"
/protein_id="CCP43216.1"
/translation="MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQ
VVAALRHLDSAAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGNLVRAEA
GAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLDRCT
GEVRWVSARDLRFGYRTSVLKHADGLAVPTVVLEVEFALDPSGRSAPLRYGELIAALN
ATSGERADPQAVREAVLALRARKGMVLDPTDHDTWSVGSFFTNPVVTQDVYERLAGDA
ATRKDGPVPHYPAPDGVKLAAGWLVERAGFGKGYPDAGAAPCRLSTKHALALTNRGGA
TAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML"
gene 571710..573065
/gene="lprQ"
/locus_tag="Rv0483"
CDS 571710..573065
/codon_start=1
/transl_table=11
/gene="lprQ"
/locus_tag="Rv0483"
/product="Probable conserved lipoprotein LprQ"
/note="Rv0483, (MTCY20G9.09), len: 451 aa. Probable
lprQ,conserved lipoprotein, equivalent to
CAC31963.1|AL583925|ML2446 possible lipoprotein from
Mycobacterium leprae (441 aa); appears longer than
ML2446,so start may be further downstream. Shows also
similarity with MLCL383_24|O07707 hypothetical 43.6 kDa
protein from Mycobacterium leprae; and to
Q49706|B1496_F2_81 (271 aa). Similar to others
lipoproteins from other organisms. Also similar to several
Mycobacterium tuberculosis hypothetical proteins e.g.
Rv0116c, Rv0192, Rv1433, Rv2518c. Contains potential
N-terminal signal sequence and appropriately positioned
PS00013 prokaryotic membrane lipoprotein lipid attachment
site."
/db_xref="EnsemblGenomes-Gn:Rv0483"
/db_xref="EnsemblGenomes-Tr:CCP43217"
/db_xref="GOA:P9WKV3"
/db_xref="InterPro:IPR005490"
/db_xref="InterPro:IPR038063"
/db_xref="InterPro:IPR041280"
/db_xref="PDB:1U8R"
/db_xref="PDB:2ISZ"
/db_xref="PDB:2IT0"
/db_xref="PDB:6D5A"
/db_xref="UniProtKB/Swiss-Prot:P9WKV3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43217.1"
/translation="MVIRVLFRPVSLIPVNNSSTPQSQGPISRRLALTALGFGVLAPN
VLVACAGKVTKLAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSA
GKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKAVPVAGKFTTVAPVKTINA
GFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDEAQGARV
HWRPREYYPAGTTVDVDAKLYGLPFGDGAYGAQDMSLHFQIGRRQVVKAEVSSHRIQV
VTDAGVIMDFPCSYGEADLARNVTRNGIHVVTEKYSDFYMSNPAAGYSHIHERWAVRI
SNNGEFIHANPMSAGAQGNSNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSY
ADGDIWDWAVDWDTWVSMSALPPPAAKPAATQIPVTAPVTPSDAPTPSGTPTTTNGPG
G"
gene complement(573046..573801)
/locus_tag="Rv0484c"
CDS complement(573046..573801)
/codon_start=1
/transl_table=11
/locus_tag="Rv0484c"
/product="Probable short-chain type oxidoreductase"
/note="Rv0484c, (MTCY20G9.10c), len: 251 aa. Probable
short-chain oxidoreductase, highly similar to others e.g.
T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase
from Streptomyces coelicolor (260 aa);
YDFG_HAEIN|P45200|HI1430 hypothetical oxidoreductase (SDR
family) from Haemophilus influenzae (252 aa), FASTA
scores: opt: 496, E(): 7.9e-25, (35.0 % identity in 243 aa
overlap); etc. Belongs to the short-chain
dehydrogenases/reductases (SDR) family. Strong
similarity,to bacterial YDFG homologs."
/db_xref="EnsemblGenomes-Gn:Rv0484c"
/db_xref="EnsemblGenomes-Tr:CCP43218"
/db_xref="GOA:P9WGR5"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43218.1"
/translation="MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADR
ITALANQIGGTAIVADVTDDAAVEALARALSRVDVLVNNAGGAKGLQFVADADLEHWR
WMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAAIEVYDGGAGYTAAKHAQGALH
RTLRGELLGKPVRLTEIAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIG
FVATRPSHVNLDQIVIRPRDQASASRRATHPVR"
gene 573984..575300
/locus_tag="Rv0485"
CDS 573984..575300
/codon_start=1
/transl_table=11
/locus_tag="Rv0485"
/product="Possible transcriptional regulatory protein"
/note="Rv0485, (MTCY20G9.11), len: 438 aa. Possible
transcriptional repressor, member of the NAGC/XYLR
repressor family; similar to several e.g.
D87820_3|O32446|D82254 NAGC N-acetylglucosamine repressor
from Vibrio cholerae (404 aa), FASTA scores: opt: 378,
E(): 1.2e-17, (26.9% identity in 350 aa overlap);
NAGC_ECOLI|P15301 N-acetylglucosamine repressor from
Escherichia coli (406 aa), FASTA scores: opt: 305, E():
1.8e-12, (21.8% identity in 357 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0485"
/db_xref="EnsemblGenomes-Tr:CCP43219"
/db_xref="GOA:P9WKV1"
/db_xref="InterPro:IPR000600"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WKV1"
/protein_id="CCP43219.1"
/translation="MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAAASVFR
AVRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAVSGAIGRPRVPVEV
NHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNAAGAALTSLADSADRYLQR
WRRRRALWVGVTLGGAVDSATGHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMA
GAELMLGMRRFAPSSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLG
GTGQLESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQQAKELL
AERARVLGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAFTAGSVLAPRDIRVT
VFGNRVQEAGAGIVSLSGLYADPLGALRRSGALDARLQDTAPEALA"
gene 575033..575069
/gene="mcr19"
ncRNA 575033..575069
/gene="mcr19"
/product="Fragment of putative small regulatory RNA"
/note="mcr19, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), cloned from M. bovis BCG
Pasteur; ends not mapped, 66-82 nt band detected by
Northern blot in M. bovis BCG Pasteur."
/ncRNA_class="other"
gene 575348..576790
/gene="mshA"
/locus_tag="Rv0486"
CDS 575348..576790
/codon_start=1
/transl_table=11
/gene="mshA"
/locus_tag="Rv0486"
/product="Glycosyltransferase MshA"
/note="Rv0486, (MTCY20G9.12), len: 480 aa.
MshA,glycosyltransferase (see citations below), highly
similar to P54138|Y486_MYCLE|ML2443 possible glycosyl
transferase from Mycobacterium leprae (428 aa); and
S72892|B2168_C2_201 probable hexosyltransferase from
Mycobacterium leprae (409 aa), FASTA scores: opt: 2375,
E(): 0, (86.4% identity in 413 aa overlap). Also highly
similar to CAC04040.1|AL391406 putative transferase from
Streptomyces coelicolor (496 aa); and similar to various
transferases e.g. NP_437172.1|NC_003078 putative
membrane-anchored glycosyltransferase protein from
Sinorhizobium meliloti (416 aa); O26550|U67601_1 LPS
biosynthesis related protein from Methanococcus jannaschii
(411 aa), FASTA score: (25.3% identity in 387 aa overlap);
etc. Also similar to CAC87824.1|AJ316594 putative
sucrose-phosphate synthase from Nostoc punctiforme (422
aa). Contains a match to Pfam entry PF00534
glycosyl_transf_1 - Glycosyl transferases group 1."
/db_xref="EnsemblGenomes-Gn:Rv0486"
/db_xref="EnsemblGenomes-Tr:CCP43220"
/db_xref="GOA:P9WMY7"
/db_xref="InterPro:IPR001296"
/db_xref="InterPro:IPR017814"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/Swiss-Prot:P9WMY7"
/inference="protein motif:PROSITE:PS00039"
/protein_id="CCP43220.1"
/translation="MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDP
RRVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVR
VAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQ
VGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTD
DEARQVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQP
LKAPDIVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHT
DLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSG
HEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNA
ERQRRGGEVISDLVAVGKPRHWTPRRGVGA"
gene 576787..577338
/locus_tag="Rv0487"
CDS 576787..577338
/codon_start=1
/transl_table=11
/locus_tag="Rv0487"
/product="Conserved hypothetical protein"
/note="Rv0487, (MTCY20G9.13), len: 183 aa. Conserved
hypothetical protein, highly similar to
P54139|Y487_MYCLE|U00018_38|ML2442 hypothetical 20.8 KDA
protein from Mycobacterium leprae (184 aa), FASTA scores:
opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa
overlap). Also highly similar to CAC04041.1|AL391406
conserved hypothetical protein from Streptomyces
coelicolor (168 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0487"
/db_xref="EnsemblGenomes-Tr:CCP43221"
/db_xref="InterPro:IPR019660"
/db_xref="UniProtKB/Swiss-Prot:P9WKU9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43221.1"
/translation="MTSSLPTVQRVIQNALEVSQLKYSQHPRPGGAPPALIVELPGER
KLKINTILSVGEHSVRVEAFVCRKPDENREDVYRFLLRRNRRLYGVAYTLDNVGDIYL
VGQMALSAVDADEVDRVLGQVLEVVDSDFNALLELGFRSSIQREWQWRLSRGESLQNL
QAFAHLRPTTMQSAQRDEKELGG"
gene 577664..578269
/locus_tag="Rv0488"
CDS 577664..578269
/codon_start=1
/transl_table=11
/locus_tag="Rv0488"
/product="Probable conserved integral membrane protein"
/note="Rv0488, (MTCY20G9.14), len: 201 aa. Probable
conserved integral membrane protein, LysE family possibly
involved in transport of Lysine, similar to others and
conserved hypothetical proteins e.g. AB93746.1|AL357613
putative membrane transport protein from Streptomyces
coelicolor (204 aa); D83100|PA4365 probable transporter
from Pseudomonas aeruginosa (200 aa); YGGA_ECOLI|P11667
hypothetical 21.7 kDa protein from Escherichia coli (197
aa), FASTA scores: opt: 382, E(): 1.1e-19, (39.1% identity
in 179 aa overlap); CGLYSEG_2 C|P94633 lysine exporter
protein (236 aa), FASTA scores: E(): 2.3e-07, (33.3%
identity in 219 aa overlap). Also similar to Rv1986 from
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0488"
/db_xref="EnsemblGenomes-Tr:CCP43222"
/db_xref="GOA:P9WK33"
/db_xref="InterPro:IPR001123"
/db_xref="InterPro:IPR004777"
/db_xref="UniProtKB/Swiss-Prot:P9WK33"
/protein_id="CCP43222.1"
/translation="MMTLKVAIGPQNAFVLRQGIRREYVLVIVALCGIADGALIAAGV
GGFAALIHAHPNMTLVARFGGAAFLIGYALLAARNAWRPSGLVPSESGPAALIGVVQM
CLVVTFLNPHVYLDTVVLIGALANEESDLRWFFGAGAWAASVVWFAVLGFSAGRLQPF
FATPAAWRILDALVAVTMIGVAVVVLVTSPSVPTANVALII"
gene 578426..579175
/gene="gpm1"
/gene_synonym="gpm"
/locus_tag="Rv0489"
CDS 578426..579175
/codon_start=1
/transl_table=11
/gene="gpm1"
/gene_synonym="gpm"
/locus_tag="Rv0489"
/product="Probable phosphoglycerate mutase 1 Gpm1
(phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)"
/note="Rv0489, (MTCY20G9.15), len: 249 aa. Probable
gpm1,phosphoglycerate mutase 1, equivalent to
P53531|PMGY_MYCLE phosphoglycerate mutase from
Mycobacterium leprae (247 aa). Also highly similar to
others e.g. PMG1_ECOLI|P31217 (249 aa), FASTA scores: opt:
805, E(): 0, (51.4% identity in 245 aa overlap); etc.
Contains PS00175 Phosphoglycerate mutase family
phosphohistidine signature, and PS00017 ATP/GTP-binding
site motif A (P-loop). Belongs to the phosphoglycerate
mutase family. Note that previously known as gpm."
/db_xref="EnsemblGenomes-Gn:Rv0489"
/db_xref="EnsemblGenomes-Tr:CCP43223"
/db_xref="GOA:P9WIC9"
/db_xref="InterPro:IPR001345"
/db_xref="InterPro:IPR005952"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="PDB:1RII"
/db_xref="UniProtKB/Swiss-Prot:P9WIC9"
/inference="protein motif:PROSITE:PS00175"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43223.1"
/translation="MANTGSLVLLRHGESDWNALNLFTGWVDVGLTDKGQAEAVRSGE
LIAEHDLLPDVLYTSLLRRAITTAHLALDSADRLWIPVRRSWRLNERHYGALQGLDKA
ETKARYGEEQFMAWRRSYDTPPPPIERGSQFSQDADPRYADIGGGPLTECLADVVARF
LPYFTDVIVGDLRVGKTVLIVAHGNSLRALVKHLDQMSDDEIVGLNIPTGIPLRYDLD
SAMRPLVRGGTYLDPEAAAAGAAAVAGQGRG"
gene 579349..580581
/gene="senX3"
/locus_tag="Rv0490"
CDS 579349..580581
/codon_start=1
/transl_table=11
/gene="senX3"
/locus_tag="Rv0490"
/product="Putative two component sensor histidine kinase
SenX3"
/note="Rv0490, (MTCY20G9.16), len: 410 aa. Putative
senX3,two-component sensor histidine kinase, transmembrane
protein (see citations below), equivalent to
O07129|SEX3_MYCBO sensor-like histidine kinase SENX3 from
Mycobacterium bovis BCG (410 aa), FASTA scores: E():
0,(99.5% identity in 410 aa overlap); and highly similar
to P54883|SEX3_MYCLE|SENX3 sensor-like histidine kinase
from Mycobacterium leprae (443 aa), FASTA score: (83.8%
identity in 408 aa overlap). Also highly similar, except
in N-terminus, to CAC31957.1|AL583925 probable
two-component system sensor histidine kinase from
Mycobacterium leprae (441 aa). Also highly similar to
sensor kinase proteins from other organisms e.g.
CAB77323.1|AL160331 putative sensor kinase protein from
Streptomyces coelicolor (426 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0490"
/db_xref="EnsemblGenomes-Tr:CCP43224"
/db_xref="GOA:P9WGK5"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:P9WGK5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43224.1"
/translation="MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWS
GITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQAL
GGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRD
FVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELS
RLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTA
LANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKA
RSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQA
REPELRSNRSQREEELSR"
repeat_region 580578..580654
/note="77 bp Mycobacterial Interspersed Repetitive
Unit,Class I (see Supply et al., 1997)"
repeat_region 580655..580731
/note="77 bp Mycobacterial Interspersed Repetitive
Unit,Class I (see Supply et al., 1997)"
repeat_region 580732..580808
/note="77 bp Mycobacterial Interspersed Repetitive
Unit,Class I (see Supply et al., 1997)"
gene 580809..581492
/gene="regX3"
/locus_tag="Rv0491"
CDS 580809..581492
/codon_start=1
/transl_table=11
/gene="regX3"
/locus_tag="Rv0491"
/product="Two component sensory transduction protein RegX3
(transcriptional regulatory protein) (probably
LuxR-family)"
/note="Rv0491, (MTCY20G9.17), len: 227 aa. RegX3, response
regulator protein (sensory transduction protein) (see
citations below), equivalent to O07130|RGX3_MYCBO|REGX3
sensory transduction protein from Mycobacterium bovis BCG
(227 aa); AAG09797.1|AF258346_2|AF258346|REGX3 response
regulator from Mycobacterium smegmatis (228 aa);
equivalent to P54884|RGX3_MYCLE|REGX3 sensory transduction
protein from Mycobacterium leprae (198 aa), FASTA scores :
E(): 0,(95.4% identity in 197 aa overlap). Also highly
similar to other response regulators e.g.
AAG43239.1|AF123314_2 |AF123314 putative response
regulator from Corynebacterium glutamicum (232 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0491"
/db_xref="EnsemblGenomes-Tr:CCP43225"
/db_xref="GOA:P9WGL9"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="PDB:2OQR"
/db_xref="UniProtKB/Swiss-Prot:P9WGL9"
/protein_id="CCP43225.1"
/translation="MTSVLIVEDEESLADPLAFLLRKEGFEATVVTDGPAALAEFDRA
GADIVLLDLMLPGMSGTDVCKQLRARSSVPVIMVTARDSEIDKVVGLELGADDYVTKP
YSARELIARIRAVLRRGGDDDSEMSDGVLESGPVRMDVERHVVSVNGDTITLPLKEFD
LLEYLMRNSGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEADPANPVHLVTV
RGLGYKLEG"
gene complement(581489..583378)
/locus_tag="Rv0492c"
CDS complement(581489..583378)
/codon_start=1
/transl_table=11
/locus_tag="Rv0492c"
/product="Probable oxidoreductase GMC-type"
/note="Rv0492c, (MT0511/MT0512, MTCY20G9.18c), len: 629
aa. Probable oxidoreductase GMC type, similar to others
except in N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN
hypothetical GMC-type oxidoreductase from Rhizobium sp.
(505 aa), FASTA scores: opt: 873, E():0, (34.3% identity
in 502 aa overlap); YTH2_RHOER|P46371 hypothetical 53.0
kDa GMC-type oxidoreductase from Rhodococcus erythropolis
(493 aa), FASTA score: (25.7% identity in 521 aa overlap);
YTH2_RHOSO|P46371 hypothetical 53.0 kDa gmc-type
oxidoreductase from Rhodococcus erythropolis (493
aa),FASTA score: (25.7% identity in 521 aa overlap);
NP_085596.1|NC_002679 probable oxidoreductase from
Mesorhizobium loti (507 aa); NP_285451.1|NC_001264 GMC
oxidoreductase from Deinococcus radiodurans (722 aa);
NP_249055.1|NC_002516 probable oxidoreductase from
Pseudomonas aeruginosa (531 aa); etc. Contains PS00198
4Fe-4S ferredoxins, iron-sulfur binding region
signature,and PS00624 GMC oxidoreductases signature 2.
Belongs to the GMC oxidoreductases family. Cofactor: FAD
(by similarity). Note that start changed since first
submission (previously 684 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0492c"
/db_xref="EnsemblGenomes-Tr:CCP43226"
/db_xref="GOA:P9WMV7"
/db_xref="InterPro:IPR000172"
/db_xref="InterPro:IPR007867"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WMV7"
/inference="protein motif:PROSITE:PS00624"
/inference="protein motif:PROSITE:PS00198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43226.1"
/translation="MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRL
PATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGLKA
IVLLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAM
VARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMG
RAVGGTTVVNSGTCFRPSLAVQRRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLE
IMGRNGRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACA
AGARIISWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSG
LGGHPRLGHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESDGVLIEATSTPPG
MGSMVFPGYGAELLRWLDRAPQIATFGAMVADRGVGTVRSVRGETVVRYDIAPGEIAK
LRVALQAIGRLLFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAAFHPTGT
AAAGADEQLCPVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAK
VVGVR"
gene complement(583375..583704)
/locus_tag="Rv0492A"
CDS complement(583375..583704)
/codon_start=1
/transl_table=11
/locus_tag="Rv0492A"
/product="Hypothetical protein"
/note="Rv0492A, len: 109 aa. Hypothetical unknown protein.
GC plot suggests CDS."
/db_xref="EnsemblGenomes-Gn:Rv0492A"
/db_xref="EnsemblGenomes-Tr:CCP43227"
/db_xref="UniProtKB/TrEMBL:Q6MX36"
/protein_id="CCP43227.1"
/translation="MSFLLDPPLLFVCGVLIERRLPVDRRDAAEAAALGVFFGASFGL
YHNVPGLGMLWRPFRAQNGRDFMWNSGVFSVDVARAEWPLHAMAAAIFATYPFFIKLG
RRLGRRI"
gene complement(583701..584690)
/locus_tag="Rv0493c"
CDS complement(583701..584690)
/codon_start=1
/transl_table=11
/locus_tag="Rv0493c"
/product="Conserved protein"
/note="Rv0493c, (MTCY20G9.19), len: 329 aa. Conserved
protein, showing some similarity to U00018_33|B2168_F2_93
from Mycobacterium leprae (167 aa), FASTA scores: opt:
166,E(): 0.00077, (35.9% identity in 131 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0493c"
/db_xref="EnsemblGenomes-Tr:CCP43228"
/db_xref="UniProtKB/Swiss-Prot:P9WKU7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43228.1"
/translation="MGESTTQPAGGAAVDDETRSAALPRWRGAAGRLEVWYATLSDPL
TRTGLWVHCETVAPTTGGPYAHGWVTWFPPDAPPGTERFGPQPAQPAAGPAWFDIAGV
RMAPAELTGRTRSLAWELSWKDTAAPLWTFPRVAWERELLPGAQVVIAPTAVFAGSLA
VGETTHRVDSWRGSVAHIYGHGNAKRWGWIHADLGDGDVLEVVTAVSHKPGLRRLAPL
AFVRFRIDGKDWPASPLPSLRMRTTLGVRHWQLEGRIGGREALIRVDQPPERCVSLGY
TDPDGAKAVCTNTEQADIHIELGGRHWSVLGTGHAEVGLRGTAAPAIKEGTPA"
gene 584695..585423
/locus_tag="Rv0494"
CDS 584695..585423
/codon_start=1
/transl_table=11
/locus_tag="Rv0494"
/product="Probable transcriptional regulatory protein
(probably GntR-family)"
/note="Rv0494, (MTCY20G9.20), len: 242 aa. Probable
transcriptional regulator, GntR family, with C-terminal
part highly similar to S72893|B2168_C2_205 hypothetical
protein from Mycobacterium leprae (105 aa). Also similar
to other transcription regulators e.g. PDHR_ECOLI|P06957
pyruvate dehydrogenase complex repressor PDHR or GENA from
Escherichia coli (254 aa), FASTA scores: opt: 284, E():
1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains
PS00043 Bacterial regulatory proteins, gntR family
signature, and probable helix-turn helix motif from aa
50-71 (Score 1229, +3.37 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0494"
/db_xref="EnsemblGenomes-Tr:CCP43229"
/db_xref="GOA:P9WMG7"
/db_xref="InterPro:IPR000524"
/db_xref="InterPro:IPR008920"
/db_xref="InterPro:IPR011711"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMG7"
/inference="protein motif:PROSITE:PS00043"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43229.1"
/translation="MVEPMNQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPP
ERDLAERLGVNRTSLRQGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKLG
PDFLVELLEIRAALGPLIGRLAAARSTPEDAEALCAALEVVQQADTAAARQAADLAYF
RVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVLTDLRAINGAVLAGDPAA
AAATVEAYLNASALRMVKSYRDRA"
gene complement(585424..586314)
/locus_tag="Rv0495c"
CDS complement(585424..586314)
/codon_start=1
/transl_table=11
/locus_tag="Rv0495c"
/product="Conserved hypothetical protein"
/note="Rv0495c, (MTCY20G9.21c), len: 296 aa. Conserved
hypothetical protein, highly similar to S72915|B2168_F1_37
hypothetical protein from Mycobacterium leprae (323
aa),FASTA scores: opt: 1615, E(): 0, (82.7% identity in
271 aa overlap); and
P54579|Y495_MYCLE|ML243|13094009|CAC31952.1|AL583925
conserved hypothetical protein from Mycobacterium leprae
(277 aa). Also highly similar to Q9X8H2|Y716_STRCO|SCE7.16
hypothetical protein from Streptomyces coelicolor (271
aa)."
/db_xref="EnsemblGenomes-Gn:Rv0495c"
/db_xref="EnsemblGenomes-Tr:CCP43230"
/db_xref="UniProtKB/Swiss-Prot:P9WKU5"
/protein_id="CCP43230.1"
/translation="MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPG
QEVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCS
HGAFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGA
CIFLNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILK
TTLTEYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAM
CKRRSQLGLIAVHPATRAAQ"
gene 586394..587380
/locus_tag="Rv0496"
CDS 586394..587380
/codon_start=1
/transl_table=11
/locus_tag="Rv0496"
/product="Conserved hypothetical protein"
/note="Rv0496, (MTCY20G9.22), len: 328 aa. Conserved
hypothetical protein, highly similar to
S72894|467046|AAA17230.1|U00018 exopolyphosphatase ppx
from Mycobacterium leprae (406 aa), FASTA scores: opt:
1902,E(): 0, (86.6% identity in 343 aa overlap); and
P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1|AL583925
hypothetical 36.2 KDA protein from Mycobacterium leprae
(339 aa). Also highly similar to hypothetical proteins and
exopolyphosphatases e.g. Q9X8H1|Y715_STRCO|SCE7.15c
hypothetical protein from Streptomyces coelicolor (309
aa). C-terminal region similar to CGU31224_1|Q46054
protein similar to ppx gene product of Mycobacterium
leprae from Cornybacterium glutamicum (140 aa), FASTA
scores: opt: 615,E(): 2.7e-33, (70.9% identity in 134 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0496"
/db_xref="EnsemblGenomes-Tr:CCP43231"
/db_xref="GOA:P9WHV5"
/db_xref="InterPro:IPR003695"
/db_xref="UniProtKB/Swiss-Prot:P9WHV5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43231.1"
/translation="MVDAHRGGHPTPMSSTKATLRLAEATDSSGKITKRGADKLISTI
DEFAKIAISSGCAELMAFATSAVRDAENSEDVLSRVRKETGVELQALRGEDESRLTFL
AVRRWYGWSAGRILNLDIGGGSLEVSSGVDEEPEIALSLPLGAGRLTREWLPDDPPGR
RRVAMLRDWLDAELAEPSVTVLEAGSPDLAVATSKTFRSLARLTGAAPSMAGPRVKRT
LTANGLRQLIAFISRMTAVDRAELEGVSADRAPQIVAGALVAEASMRALSIEAVEICP
WALREGLILRKLDSEADGTALIESSSVHTSVRAVGGQPADRNAANRSRGSKP"
gene 587377..588309
/locus_tag="Rv0497"
CDS 587377..588309
/codon_start=1
/transl_table=11
/locus_tag="Rv0497"
/product="Probable conserved transmembrane protein"
/note="Rv0497, (MTCY20G9.23), len: 310 aa. Probable
conserved transmembrane protein, equivalent (but shorter
in C-terminus) to P54580|Y497_MYCLE|ML2433 hypothetical
37.9 KDA protein from Mycobacterium leprae (355 aa).
N-terminus highly similar to S72922|B2168_C1_166|467074
hypothetical protein from Mycobacterium leprae (118 aa),
FASTA scores: opt: 350, E(): 1.4e-12, (57.9% identity in
114 aa overlap); and hydrophobic C-terminus, highly
similar to S72895|B2168_C2_209|467047 hypothetical protein
from Mycobacterium leprae (241 aa), FASTA scores: opt:
473, E(): 8e-19, (53.9% identity in 241 aa). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0497"
/db_xref="EnsemblGenomes-Tr:CCP43232"
/db_xref="GOA:P9WKU3"
/db_xref="UniProtKB/Swiss-Prot:P9WKU3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43232.1"
/translation="MTGPHPETESSGNRQISVAELLARQGVTGAPARRRRRRRGDSDA
ITVAELTGEIPIIRDDHHHAGPDAHASQSPAANGRVQVGEAAPQSPAEPVAEQVAEEP
TRTVYWSQPEPRWPKSPPQDRRESGPELSEYPRPLRHTHSDRAPAGPPSGAEHMSPDP
VEHYPDLWVDVLDTEVGEAEAETEVREAQPGRGERHAAAAAAGTDVEGDGAAEARVAR
RALDVVPTLWRGALVVLQSILAVAFGAGLFIAFDQLWRWNSIVALVLSVMVILGLVVS
VRAVRKTEDIASTLIAVAVGALITLGPLALLQSG"
gene 588325..589167
/locus_tag="Rv0498"
CDS 588325..589167
/codon_start=1
/transl_table=11
/locus_tag="Rv0498"
/product="Conserved hypothetical protein"
/note="Rv0498, (MTCY20G9.24), len: 280 aa. Conserved
hypothetical protein, highly similar to
P54581|Y498_MYCLE|ML2432 hypothetical 30.5 KDA protein
from Mycobacterium leprae (280 aa); and
S72896|B2168_C2_210 hypothetical protein from
Mycobacterium leprae (244 aa),FASTA scores: opt: 1486,
E():0, (89.3% identity in 244 aa overlap). Also similar to
Q9X8H0|Y714_STRCO|SCE7.14c hypothetical protein from
Streptomyces coelicolor."
/db_xref="EnsemblGenomes-Gn:Rv0498"
/db_xref="EnsemblGenomes-Tr:CCP43233"
/db_xref="InterPro:IPR013022"
/db_xref="InterPro:IPR036237"
/db_xref="UniProtKB/Swiss-Prot:P9WKU1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43233.1"
/translation="MRPAIKVGLSTASVYPLRAEAAFEYADRLGYDGVELMVWGESVS
QDIDAVRKLSRRYRVPVLSVHAPCLLISQRVWGANPILKLDRSVRAAEQLGAQTVVVH
PPFRWQRRYAEGFSDQVAALEAASTVMVAVENMFPFRADRFFGAGQSRERMRKRGGGP
GPAISAFAPSYDPLDGNHAHYTLDLSHTATAGTDSLDMARRMGPGLVHLHLCDGSGLP
ADEHLVPGRGTQPTAEVCQMLAGSGFVGHVVLEVSTSSARSANERESMLAESLQFART
HLLR"
gene 589183..590058
/locus_tag="Rv0499"
CDS 589183..590058
/codon_start=1
/transl_table=11
/locus_tag="Rv0499"
/product="Conserved hypothetical protein"
/note="Rv0499, (MTCY20G9.25), len: 291 aa. Conserved
hypothetical protein, showing some similarity to
AL031184|SC2A11_16|T34762 hypothetical protein from
Streptomyces coelicolor (340 aa), FASTA scores: opt:
240,E(): 1.8e-07, (28.9% identity in 270 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0499"
/db_xref="EnsemblGenomes-Tr:CCP43234"
/db_xref="GOA:P9WKT9"
/db_xref="InterPro:IPR001206"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR042171"
/db_xref="UniProtKB/Swiss-Prot:P9WKT9"
/protein_id="CCP43234.1"
/translation="MNALFTTAMALRPLDSDPGNPACRVFEGELNEHWTIGPKVHGGA
MVALCANAARTAYGAAGQQPMRQPVAVSASFLWAPDPGTMRLVTSIRKRGRRISVADV
ELTQGGRTAVHAVVTLGEPEHFLPGVDGSGGASGTAPLLSANPVVELMAPEPPEGVVP
IGPGHQLAGLVHLGEGCDVRPVLSTLRSATDGRPPVIQLWARPRGVAPDALFALLCGD
LSAPVTFAVDRTGWAPTVALTAYLRALPADGWLRVLCTCVEIGQDWFDEDHIVVDRLG
RIVVQTRQLAMVPAQ"
gene 590083..590970
/gene="proC"
/locus_tag="Rv0500"
CDS 590083..590970
/codon_start=1
/transl_table=11
/gene="proC"
/locus_tag="Rv0500"
/product="Probable pyrroline-5-carboxylate reductase ProC
(P5CR) (P5C reductase)"
/note="Rv0500, (MTCY20G9.26), len: 295 aa. Probable
proC,Pyrroline-5-carboxylate reductase (see citation
below),equivalent to P46725|PROC_MYCLE
pyrroline-5-carboxylate reductase from Mycobacterium
leprae (294 aa), FASTA scores: opt: 1473, E(): 0, (82.4%
identity in 295 aa overlap). Also similar to others e.g.
P46540|PROC_CORGL pyrroline-5-carboxylate reductase from
Corynebacterium glutamicum (270 aa);
T36286|4803683|CAB42663.1|AL049819 pyrroline-5-carboxylate
reductase from Streptomyces coelicolor (284 aa); etc.
Belongs to the pyrroline-5-carboxylate reductase family."
/db_xref="EnsemblGenomes-Gn:Rv0500"
/db_xref="EnsemblGenomes-Tr:CCP43235"
/db_xref="GOA:P9WHU7"
/db_xref="InterPro:IPR000304"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR028939"
/db_xref="InterPro:IPR029036"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WHU7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43235.1"
/translation="MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRA
NYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVT
VVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDA
VGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGS
AAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAV
DAAVQAAKSRSEQLRITPE"
gene 591111..591347
/locus_tag="Rv0500A"
CDS 591111..591347
/codon_start=1
/transl_table=11
/locus_tag="Rv0500A"
/product="Conserved protein"
/note="Rv0500A, len: 78 aa. Conserved protein, similar to
proteins from Mycobacterium leprae and Streptomyces
coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid
B2168 (86 aa), FASTA scores: opt: 428, E(): 1.3e-27,
(82.6% identity in 86 aa overlap); AL079345|SCE68_26 from
Streptomyces coelicolor cosmid E6 (70 aa), FASTA scores:
opt: 252, E(): 1.2 e-13, (72.2 identity in 54 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0500A"
/db_xref="EnsemblGenomes-Tr:CCP43236"
/db_xref="GOA:P9WKT7"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR010093"
/db_xref="InterPro:IPR041657"
/db_xref="UniProtKB/Swiss-Prot:P9WKT7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43236.1"
/translation="MTSTNGPSARDTGFVEGQQAKTQLLTVAEVAALMRVSKMTVYRL
VHNGELPAVRVGRSFRVHAKAVHDMLETSYFDAG"
gene 591475..591576
/locus_tag="Rv0500B"
CDS 591475..591576
/codon_start=1
/transl_table=11
/locus_tag="Rv0500B"
/product="Conserved hypothetical protein"
/note="Rv0500B, len: 33 aa. Conserved hypothetical
protein. Basic protein 18 of the 33 aa are Arg or Lys,
with strong similarity to AL079345|SCE68_25 protein from
Streptomyces coelicolor cosmid E6 (32 aa), FASTA scores:
opt: 176, E(): 1e-06, (93.1% identity in 29 aa overlap).
Same gene arrangement in both actinomycetes."
/db_xref="EnsemblGenomes-Gn:Rv0500B"
/db_xref="EnsemblGenomes-Tr:CCP43237"
/db_xref="InterPro:IPR013177"
/db_xref="UniProtKB/Swiss-Prot:P9WKT5"
/protein_id="CCP43237.1"
/translation="MGSVIKKRRKRMSKKKHRKLLRRTRVQRRKLGK"
gene 591654..592784
/gene="galE2"
/gene_synonym="galE1"
/locus_tag="Rv0501"
CDS 591654..592784
/codon_start=1
/transl_table=11
/gene="galE2"
/gene_synonym="galE1"
/locus_tag="Rv0501"
/product="Possible UDP-glucose 4-epimerase GalE2
(galactowaldenase) (UDP-galactose 4-epimerase) (uridine
diphosphate galactose 4-epimerase) (uridine
diphospho-galactose 4-epimerase)"
/note="Rv0501, (MTCY20G9.28), len: 376 aa. Possible
galE2,UDP-glucose 4-epimerase, highly similar (except in
N-terminus) to CAC31944.1|AL583925 possible glucose
epimerase/dehydratase from Mycobacterium leprae (364 aa).
N-terminus highly similar to
S72923|B2168_C1_174|467075|AAA17259.1|U00018 hypothetical
protein from Mycobacterium leprae (180 aa), FASTA scores:
opt: 934, E(): 0, (89.6% identity in 164 aa overlap); and
C-terminus highly similar to
S72898|467050|AAA17234.1|U00018 hypothetical protein from
Mycobacterium leprae (168 aa), FASTA scores: opt: 928,
E(): 0, (82.7% identity in 168 aa overlap). Also highly
similar to T36274|5123671|CAB45360.1|AL079345 probable
epimerase from Streptomyces coelicolor (353 aa); and
similar in part to other epimerases e.g. GALE_ECOLI|P09147
UDP-glucose 4-epimerase from Escherichia coli (338 aa),
FASTA scores: opt: 241, E(): 6.7e-09, (28.2% identity in
294 aa overlap); etc. Belongs to the sugar epimerase
family. Cofactor: NAD. Note that previously known as
galE1."
/db_xref="EnsemblGenomes-Gn:Rv0501"
/db_xref="EnsemblGenomes-Tr:CCP43238"
/db_xref="GOA:P9WKT3"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WKT3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43238.1"
/translation="MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLA
QNPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAAS
YAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDS
SSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPL
VPTIFGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVP
VPGFGVWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDD
YFRGRGLTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR"
gene 592791..593867
/locus_tag="Rv0502"
CDS 592791..593867
/codon_start=1
/transl_table=11
/locus_tag="Rv0502"
/product="Conserved protein"
/note="Rv0502, (MTCY20G9.29), len: 358 aa. Conserved
protein, equivalent to P54878|Y502_MYCLE|ML2427
hypothetical 40.5 KDA protein from Mycobacterium leprae
(367 aa), FASTA scores: opt: 2042, E(): 0, (84.1% identity
in 365 aa overlap). Also similar to T36273|SCE68.23c
hypothetical protein from Streptomyces coelicolor (355
aa). C-terminal similar to AL021529|SC10A5_4|T34572
hypothetical protein from Streptomyces coelicolor (295
aa), FASTA score: (57.8% identity in 263 aa overlap); and
to hypothetical proteins from Mycobacterium tuberculosis
Rv1920|G70808 (287 aa); and Rv1428c|G70914 (275 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0502"
/db_xref="EnsemblGenomes-Tr:CCP43239"
/db_xref="GOA:P9WKT1"
/db_xref="InterPro:IPR002123"
/db_xref="InterPro:IPR016676"
/db_xref="UniProtKB/Swiss-Prot:P9WKT1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43239.1"
/translation="MGNVAGETRANVIPLHTNRSRVAARRRAGQRAESRQHPSLLSDP
NDRASAEQIAAVVREIDEHRRAAGATTSSTEATPNDLAQLVAAVAGFLRQRLTGDYSV
DEFGFDPHFNSAIVRPLLRFFFKSWFRVEVSGVENIPRDGAALVVANHAGVLPFDGLM
LSVAVHDEHPAHRDLRLLAADMVFDLPVIGEAARKAGHTMACTTDAHRLLASGELTAV
FPEGYKGLGKRFEDRYRLQRFGRGGFVSAALRTKAPIVPCSIIGSEEIYPMLTDVKLL
ARLFGLPYFPITPLFPLAGPVGLVPLPSKWRIAFGEPICTADYASTDADDPMVTFELT
DQVRETIQQTLYRLLAGRRNIFFG"
gene complement(593871..594779)
/gene="cmaA2"
/gene_synonym="cma2"
/locus_tag="Rv0503c"
CDS complement(593871..594779)
/codon_start=1
/transl_table=11
/gene="cmaA2"
/gene_synonym="cma2"
/locus_tag="Rv0503c"
/product="Cyclopropane-fatty-acyl-phospholipid synthase 2
CmaA2 (cyclopropane fatty acid synthase) (CFA synthase)
(cyclopropane mycolic acid synthase 2) (mycolic acid
trans-cyclopropane synthetase)"
/note="Rv0503c, (MTCY20G9.30c), len: 302 aa. CmaA2
(alternate gene name:
cma2),cyclopropane-fatty-acyl-phospholipid synthase 2
(mycolic acid trans-cyclopropane synthetase) (see
citations below). Note that this protein has 302 aa and
not 322 aa: we have chosen a different initiation codon on
the basis of homology. Equivalent to S72886|B2168_F3_130
hypothetical protein from Mycobacterium leprae (308 aa),
FASTA score: (78.9% identity in 303 aa overlap); and
highly similar to other proteins from Mycobacterium
leprae. Also similar to other proteins from Mycobacterium
tuberculosis and Mycobacterium bovis BCG e.g.
MTV038_14|UMAA2|Rv0470c|MTV038.14 putative mycolic acid
synthesis/modification protein (287 aa) (57.2% identity in
297 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0503c"
/db_xref="EnsemblGenomes-Tr:CCP43240"
/db_xref="GOA:P9WPB5"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:1KPI"
/db_xref="PDB:3HEM"
/db_xref="UniProtKB/Swiss-Prot:P9WPB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43240.1"
/translation="MTSQGDTTSGTQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCA
YFERPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEYDVNVIGLT
LSENQYAHDKAMFDEVDSPRRKEVRIQGWEEFDEPVDRIVSLGAFEHFADGAGDAGFE
RYDTFFKKFYNLTPDDGRMLLHTITIPDKEEAQELGLTSPMSLLRFIKFILTEIFPGG
RLPRISQVDYYSSNAGWKVERYHRIGANYVPTLNAWADALQAHKDEAIALKGQETYDI
YMHYLRGCSDLFRDKYTDVCQFTLVK"
gene complement(594802..595302)
/locus_tag="Rv0504c"
CDS complement(594802..595302)
/codon_start=1
/transl_table=11
/locus_tag="Rv0504c"
/product="Conserved protein"
/note="Rv0504c, (MTCY20G9.31c), len: 166 aa. Conserved
protein, equivalent to P54879|Y504_MYCLE|ML2425
hypothetical 18.7 KDA protein from Mycobacterium leprae
(166 aa), FASTA scores: opt: 884, E(): 0, (83.1% identity
in 166 aa overlap); and highly similar to other proteins
from Mycobacterium leprae. Also highly similar to
CAB77410.1|AL160431|SCD82.07 hypothetical protein from
Streptomyces coelicolor (150 aa). Also similar to M.
tuberculosis hypothetical proteins Rv0635|H70612 (158 aa);
and Rv0637|B70613 (166 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0504c"
/db_xref="EnsemblGenomes-Tr:CCP43241"
/db_xref="GOA:P9WFK3"
/db_xref="InterPro:IPR016709"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR039569"
/db_xref="UniProtKB/Swiss-Prot:P9WFK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43241.1"
/translation="MTVPEEAQTLIGKHYRAPDHFLVGREKIREFAVAVKDDHPTHYS
EPDAAAAGYPALVAPLTFLAIAGRRVQLEIFTKFNIPINIARVFHRDQKFRFHRPILA
NDKLYFDTYLDSVIESHGTVLAEIRSEVTDAEGKPVVTSVVTMLGEAAHHEADADATV
AAIASI"
gene complement(595464..596585)
/gene="serB1"
/gene_synonym="serB"
/locus_tag="Rv0505c"
CDS complement(595464..596585)
/codon_start=1
/transl_table=11
/gene="serB1"
/gene_synonym="serB"
/locus_tag="Rv0505c"
/product="Possible phosphoserine phosphatase SerB1 (PSP)
(O-phosphoserine phosphohydrolase) (pspase)"
/note="Rv0505c, (MTCY20G9.32c), len: 373 aa. Possible
serB1, phosphoserine phosphatase, equivalent (but longer
~70 aa in N-terminus) to S72914|serB phosphoserine
phosphatase from Mycobacterium leprae (300 aa), FASTA
scores: opt: 1570, E(): 0, (83.0% identity in 306 aa
overlap). C-terminus highly similar to CAB55344.1|AJ010584
phosphoserine phosphatase from Streptomyces coelicolor
(266 aa). Low similarity to SERB_ECOLI|P06862
phosphoserine phosphatase from Escherichia coli strains
K12 and O157:H7 (322 aa), FASTA scores: opt: 148, E():
0.043, (24.0% identity in 150 aa overlap). C-terminus is
also similar to O33611|AB004855_1|IMD_STRCN protein
involved in inhibition of morphological differentiation
from Streptomyces cyaneus (277 aa), FASTA score: (37.7%
identity in 252 aa overlap). Seems to belong to the SERB
family. Note that previously known as serB."
/db_xref="EnsemblGenomes-Gn:Rv0505c"
/db_xref="EnsemblGenomes-Tr:CCP43242"
/db_xref="GOA:P9WGJ3"
/db_xref="InterPro:IPR006385"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WGJ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43242.1"
/translation="MGLTCWPRTAAGRVHDESRCGLANFDTALGLQINPRQPRAPPRI
CRIGLITAAASATGQAPRLGVMMVSSHLGSPDQAGHVDLASPADPPPPDASASHSPVD
MPAPVAAAGSDRQPPIDLTAAAFFDVDNTLVQGSSAVHFGRGLAARHYFTYRDVLGFL
YAQAKFQLLGKENSNDVAAGRRKALAFIEGRSVAELVALGEEIYDEIIADKIWDGTRE
LTQMHLDAGQQVWLITATPYELAATIARRLGLTGALGTVAESVDGIFTGRLVGEILHG
TGKAHAVRSLAIREGLNLKRCTAYSDSYNDVPMLSLVGTAVAINPDARLRSLARERGW
EIRDFRIARKAARIGVPSALALGAAGGALAALASRRQSR"
gene 596759..597202
/gene="mmpS2"
/locus_tag="Rv0506"
CDS 596759..597202
/codon_start=1
/transl_table=11
/gene="mmpS2"
/locus_tag="Rv0506"
/product="Probable conserved membrane protein MmpS2"
/note="Rv0506, (MTCY20G9.33), len: 147 aa. Probable
mmpS2,conserved membrane protein (see citation below),
highly similar to other Mycobacterial proteins e.g.
C-terminus of AAD44232.1|AF143772_38|AF143772|TmtpA from
Mycobacterium avium (221 aa); P54880|MMS4_MYCLE|MMPS4
putative membrane protein from Mycobacterium leprae (154
aa), FASTA scores: opt: 392, E(): 1.3e-20, (43.7% identity
in 151 aa overlap); and the putative membrane proteins
from Mycobacterium tuberculosis MTV040_5, MTCY4D9_16,
MTV037_15. Belongs to the MmpS family. Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0506"
/db_xref="EnsemblGenomes-Tr:CCP43243"
/db_xref="GOA:P9WJT3"
/db_xref="InterPro:IPR008693"
/db_xref="InterPro:IPR038468"
/db_xref="UniProtKB/Swiss-Prot:P9WJT3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43243.1"
/translation="MRMISVSGAVKRMWLLLAIVVVAVVGGLGIYRLHSIFGVHEQPT
VMVKPDFDVPLFNPKRVTYEVFGPAKTAKIAYLDPDARVHRLDSVSLPWSVTVETTLP
AVSVNLMAQSNADVISCRIIVNGAVKDERSETSPRALTSCQVSSG"
gene 597199..600105
/gene="mmpL2"
/locus_tag="Rv0507"
CDS 597199..600105
/codon_start=1
/transl_table=11
/gene="mmpL2"
/locus_tag="Rv0507"
/product="Probable conserved transmembrane transport
protein MmpL2"
/note="Rv0507, (MTCY20G9.34), len: 968 aa. Probable
mmpL2,conserved transmembrane transport protein (see
citations below), member of RND superfamily, highly
similar to other Mycobacterial proteins e.g. YV34_MYCLE
from Mycobacterium leprae (959 aa), FASTA scores: opt:
3699, E(): 0, (58.3% identity in 940 aa overlap); and the
Mycobacterium tuberculosis proteins MTV037_14, MTV040_4,
MTCY98_8,MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19, etc.
Also similar to STMACTII_3|SC10A5_9 from Streptomyces
coelicolor; and BSUB0|004_12 from Bacillus subtilis.
C-terminal half similar to Q50086|U1740AB from
Mycobacterium leprae (386 aa), FASTA scores: opt:
1526,E(): 0, (61.5% identity in 371 aa overlap). Belongs
to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv0507"
/db_xref="EnsemblGenomes-Tr:CCP43244"
/db_xref="GOA:P9WJV7"
/db_xref="InterPro:IPR004707"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJV7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43244.1"
/translation="MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFTAFVNLAVPQL
EVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSD
LMRKLSADTRHVAHIQDFWGDPLTAAGSQSADDRAAYVVVYLVGNNETEAYDSVHAVR
HMVDTTPPPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVIT
AVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGRYH
ESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFETLGAPIAIGML
VAVLAALTLGPAVLTVGSFFKLFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASI
GLLALPSYRTTYDLRKFMPASMPSNVGDAAAGRRFSRARLNPEVLLIETDHDMRNPVD
MLVLDKVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRI
DDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDF
FRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQMR
AQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQIDDSFYLPQ
SAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGISRVEPIKREAREAIKGTPL
QGAAIYLGGTAATFKDIREGARYDLLIAGVAAISLILIIMMIITRSVVAAVVIVGTVV
LSMGASFGLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYNLLLISRLKEEIGAGLN
TGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFM
TPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQHPSATGAHE"
gene 600098..600391
/locus_tag="Rv0508"
CDS 600098..600391
/codon_start=1
/transl_table=11
/locus_tag="Rv0508"
/product="Conserved hypothetical protein"
/note="Rv0508, (MTCY20G9.35), len: 97 aa. Conserved
hypothetical protein, showing similarity with
T36269|5123666|CAB45355.1|AL079345 probable redoxin from
Streptomyces coelicolor (101 aa), FASTA scores: opt:
160,E(): 3.4e-05, (33.3% identity in 75 aa overlap); and
E81943|NMA0966 probable thioredoxin from Neisseria
meningitidis group a strain Z2491 (77 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0508"
/db_xref="EnsemblGenomes-Tr:CCP43245"
/db_xref="GOA:P9WKS9"
/db_xref="InterPro:IPR008554"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/Swiss-Prot:P9WKS9"
/protein_id="CCP43245.1"
/translation="MSRPQVELLTRAGCAICVRVAEQLAELSSELGFDMMTIDVDVAA
STGNPGLRAEFGDRLPVVLLDGREHSYWEVDEHRLRADIARSTFGSPPDKRLP"
gene 600441..601847
/gene="hemA"
/locus_tag="Rv0509"
CDS 600441..601847
/codon_start=1
/transl_table=11
/gene="hemA"
/locus_tag="Rv0509"
/product="Probable glutamyl-tRNA reductase HemA (GLUTR)"
/note="Rv0509, (MTCY20G9.36), len: 468 aa. Probable
hemA,glutamyl-tRNA reductase, equivalent to
HEM1_MYCLE|P46724 glutamyl-tRNA reductase from
Mycobacterium leprae (467 aa),FASTA scores: opt: 2377,
E(): 0, (82.3% identity in 463 aa overlap). Also highly
similar (sometimes in part) to others e.g.
Q9WX15|HEM1_STRCO glutamyl-tRNA reductase from
Streptomyces coelicolor (581 aa); P16618|HEM1_BACSU|HEMA
glutamyl-tRNA reductase from Bacillus subtilis (455 aa);
etc. Contains PS00747 Glutamyl-tRNA reductase signature.
Belongs to the glutamyl-tRNA reductase family."
/db_xref="EnsemblGenomes-Gn:Rv0509"
/db_xref="EnsemblGenomes-Tr:CCP43246"
/db_xref="GOA:P9WMP7"
/db_xref="InterPro:IPR000343"
/db_xref="InterPro:IPR006151"
/db_xref="InterPro:IPR015895"
/db_xref="InterPro:IPR015896"
/db_xref="InterPro:IPR018214"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036343"
/db_xref="InterPro:IPR036453"
/db_xref="UniProtKB/Swiss-Prot:P9WMP7"
/inference="protein motif:PROSITE:PS00747"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43246.1"
/translation="MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEA
MVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHLFA
VASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHELAQRALSVGKRVHSETAIDA
AGASVVSVALGMAERKLGSLAGTTAVVIGAGAMGALSAVHLTRAGVGHIQVLNRSLSR
AQRLARRIRESGVPAEALALDRLANVLADADVVVSCTGAVRPVVSLADVHHALAAARR
DEATRPLVICDLGMPRDVDPAVARLPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAA
EVASYLVGQRMAEVTPTVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRV
VDKLLHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVATAGELPVVPSGFDAE
SRRGGGDMQSSPKRSPSN"
gene 601857..602786
/gene="hemC"
/locus_tag="Rv0510"
CDS 601857..602786
/codon_start=1
/transl_table=11
/gene="hemC"
/locus_tag="Rv0510"
/product="Probable porphobilinogen deaminase HemC (PBG)
(hydroxymethylbilane synthase) (HMBS)
(pre-uroporphyrinogen synthase)"
/note="Rv0510, (MTCY21C8.01-MTCY20G9.37), len: 309 aa.
Probable hemC, hydroxymethylbilane synthase
(porphobilinogen deaminase), equivalent to
HEM3B|Q49808|HEM3_MYCLE porphobilinogen deaminase from
Mycobacterium leprae (315 aa), FASTA scores: opt: 889,
E(): 0, (88.1% identity in 159 aa overlap). Also highly
similar to others e.g. Q9WX16|HE31_STRCO probable
porphobilinogen deaminase from Streptomyces coelicolor
(319 aa); Q9L6Q2|HEM3_SALTY porphobilinogen deaminase from
Salmonella typhimurium (313 aa); etc. Belongs to the HMBS
family. Cofactor: covalently binds a dipyrromethane
cofactor to which the porphobilinogen subunits are ADDED."
/db_xref="EnsemblGenomes-Gn:Rv0510"
/db_xref="EnsemblGenomes-Tr:CCP43247"
/db_xref="GOA:P9WMP3"
/db_xref="InterPro:IPR000860"
/db_xref="InterPro:IPR022417"
/db_xref="InterPro:IPR022418"
/db_xref="InterPro:IPR022419"
/db_xref="InterPro:IPR036803"
/db_xref="UniProtKB/Swiss-Prot:P9WMP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43247.1"
/translation="MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMA
PIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVA
RDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIV
VARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRA
AVTAERALLADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRAS
GIGSCGRARELGLSVAAELFELGARELMWGVRH"
gene 602819..604516
/gene="hemD"
/gene_synonym="cysG"
/locus_tag="Rv0511"
CDS 602819..604516
/codon_start=1
/transl_table=11
/gene="hemD"
/gene_synonym="cysG"
/locus_tag="Rv0511"
/product="Probable uroporphyrin-III C-methyltransferase
HemD (uroporphyrinogen III methylase) (urogen III
methylase) (SUMT) (urogen III methylase) (UROM)"
/note="Rv0511, (MTCY21C8.02), len: 565 aa. Probable hemD
(alternate gene name: cysG), uroporphyrin-III
C-methyltransferase, highly similar to others e.g.
CAC31936.1|AL583925 possible uroporphyrin-III
C-methyltransferase from Mycobacterium leprae (563 aa);
and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA
scores: opt: 1946, E(): 0, (83.3% identity in 472 aa
overlap); T36265|5123662|CAB45351.1|AL079345 probable
uroporphyrin-III C-methyltransferase from Streptomyces
coelicolor (565 aa); and similar to others e.g.
AAK00606.1|AF221100_3|AF221100 from Selenomonas
ruminantium subsp. ruminantium (505 aa); etc. Also similar
to Rv2071c and Rv2847c from Mycobacterium tuberculosis.
Note that previously known as cysG."
/db_xref="EnsemblGenomes-Gn:Rv0511"
/db_xref="EnsemblGenomes-Tr:CCP43248"
/db_xref="GOA:Q6MX34"
/db_xref="InterPro:IPR000878"
/db_xref="InterPro:IPR003754"
/db_xref="InterPro:IPR014776"
/db_xref="InterPro:IPR035996"
/db_xref="InterPro:IPR036108"
/db_xref="UniProtKB/TrEMBL:Q6MX34"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43248.1"
/translation="MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPD
VPEPVVALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPAL
GDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASS
AVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQ
LAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIG
KTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRS
PAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTAD
RVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRER
GWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTII
ACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR"
gene 604602..605591
/gene="hemB"
/locus_tag="Rv0512"
CDS 604602..605591
/codon_start=1
/transl_table=11
/gene="hemB"
/locus_tag="Rv0512"
/product="Probable delta-aminolevulinic acid dehydratase
HemB (porphobilinogen synthase) (ALAD) (ALADH)"
/note="Rv0512, (MTCY20G10.02), len: 329 aa. Probable
hemB,delta-aminolevulinic acid dehydratase, equivalent to
46723|HEM2_MYCLE delta-aminolevulinic acid dehydratase
from Mycobacterium leprae (329 aa). Also highly similar to
many e.g. P54919|HEM2_STRCO from Streptomyces coelicolor
(330 aa); HEM2_ECOLI|P15002 from Escherichia coli (323
aa),FASTA scores: opt: 942, E(): 0, (47.6% identity in 317
aa overlap); etc. Contains PS00169 Delta-aminolevulinic
acid dehydratase active site. Belongs to the ALADH family.
Cofactor: zinc."
/db_xref="EnsemblGenomes-Gn:Rv0512"
/db_xref="EnsemblGenomes-Tr:CCP43249"
/db_xref="GOA:P9WMP5"
/db_xref="InterPro:IPR001731"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR030656"
/db_xref="UniProtKB/Swiss-Prot:P9WMP5"
/inference="protein motif:PROSITE:PS00169"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43249.1"
/translation="MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGI
DEPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDG
ILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVA
QAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSS
LSGDRRTYQQEPGNAAEALREIELDLDEGADIVMVKPAMGYLDVVAAAADVSPVPVAA
YQVSGEYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYWAVDAAGWLT"
gene 605604..606152
/locus_tag="Rv0513"
CDS 605604..606152
/codon_start=1
/transl_table=11
/locus_tag="Rv0513"
/product="Possible conserved transmembrane protein"
/note="Rv0513, (MTCY20G10.03), len: 182 aa. Possible
conserved transmembrane protein, with its N-terminus
highly similar to S72925|B2168_C1_182 hypothetical protein
from Mycobacterium leprae (103 aa), FASTA scores: opt:
217, E(): 8.2e-14, (45.3 % identity in 106 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0513"
/db_xref="EnsemblGenomes-Tr:CCP43250"
/db_xref="GOA:O33358"
/db_xref="InterPro:IPR016844"
/db_xref="UniProtKB/TrEMBL:O33358"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43250.1"
/translation="MTPTGDTKPKLLFYEPGASWYWVLTGPLAAVSVLLLEISSGAGV
GLITPAIFLVMVSAFVALQVKAARIHTSVELTHDALRQGTETIRLAEIVKIYPEADGR
ETSGEEPAKWQSARTLGELVGVPRGRVGIGLKLTGGRTAQAWARRHQQLRAALTPLVQ
ERLGPVDSDVADVNGDDAGPAR"
gene 606149..606448
/locus_tag="Rv0514"
CDS 606149..606448
/codon_start=1
/transl_table=11
/locus_tag="Rv0514"
/product="Possible transmembrane protein"
/note="Rv0514, (MTCY20G10.04), len: 99 aa. Possible
transmembrane protein."
/db_xref="EnsemblGenomes-Gn:Rv0514"
/db_xref="EnsemblGenomes-Tr:CCP43251"
/db_xref="GOA:O33359"
/db_xref="UniProtKB/TrEMBL:O33359"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43251.1"
/translation="MIARYRAGAELFLACAALAGSAASWSRTRSTVAVAPVIDGQPVT
LSVVYHPQPLVLTLLLATIAGVLSVVGTARLRRARAGLNAHPDGLNQRPPGGWCH"
gene 606551..608062
/locus_tag="Rv0515"
CDS 606551..608062
/codon_start=1
/transl_table=11
/locus_tag="Rv0515"
/product="Conserved 13E12 repeat family protein"
/note="Rv0515, (MTCY20G10.05), len: 503 aa. Part of M.
tuberculosis 13E12 repeat family. Almost identical to
Rv0336 (99.8% identity in 503 aa overlap), possibly due to
a recent gene duplication. Also similar to other M.
tuberculosis hypothetical 13E12 repeat proteins e.g.
Rv1148c, Rv1945, etc."
/db_xref="EnsemblGenomes-Gn:Rv0515"
/db_xref="EnsemblGenomes-Tr:CCP43252"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:O33360"
/protein_id="CCP43252.1"
/translation="MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAA
AQLVALGELFAYRWSRCGGREEWVMDTMAAVAAEVAAALRISQGLAASRLRYARAMRE
RLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAANVARWPSMTKARLA
GQVDKIVARADADAVRRRKEYQAQRQFWVGESQDGVCQIGGSLLAVDAHALDARLSAL
AGTVCEHDPRSREQRRADALGALAGGADRLGCGCGRADCAAGKRPAAPPVVIHLIAEA
ATINGTGSAPASQMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADF
VRCRDLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFWGWRDQ
QLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMPK
RRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDHNDDPPPF"
gene complement(608059..608535)
/locus_tag="Rv0516c"
CDS complement(608059..608535)
/codon_start=1
/transl_table=11
/locus_tag="Rv0516c"
/product="Possible anti-anti-sigma factor"
/note="Rv0516c, (MTCY20G10.06c), len: 158 aa. Possible
anti-anti-sigma factor, showing some similarity to
Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128
aa), FASTA scores: E(): 0.0012, (27.4% identity in 124 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0516c"
/db_xref="EnsemblGenomes-Tr:CCP43253"
/db_xref="GOA:O33361"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR036513"
/db_xref="UniProtKB/TrEMBL:O33361"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43253.1"
/translation="MTTTIPTSKSACSVTTRPGNAAVDYGGAQIRAYLHHLATVVTIR
GEIDAANVEQISEHVRRFSLGTNPMVLDLSELSHFSGAGISLLCILDEDCRAAGVQWA
LVASPAVVEQLGGRCDQGEHESMFPMARSVHKALHDLADAIDRRRQLVLPLISRSA"
gene 608746..610056
/locus_tag="Rv0517"
CDS 608746..610056
/codon_start=1
/transl_table=11
/locus_tag="Rv0517"
/product="Possible membrane acyltransferase"
/note="Rv0517, (MTCY20G10.07), len: 436 aa. Possible
acyltransferase, integral membrane protein, equivalent
(but longer 26 aa in N-terminus) to AAK44761.1|AE006954
putative acyltransferase from Mycobacterium tuberculosis
strain CDC1551 (410 aa). Also similar to many
acyltransferases e.g. MDMB_STRMY|Q00718 from Streptomyces
mycarofaciens (387 aa), FASTA scores: opt: 200, E():
1.1e-08, (28.2% identity in 394 aa overlap). And similar
to Rv0111, Rv0228, Rv1254,Rv1565c from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0517"
/db_xref="EnsemblGenomes-Tr:CCP43254"
/db_xref="GOA:O33362"
/db_xref="InterPro:IPR002656"
/db_xref="UniProtKB/TrEMBL:O33362"
/protein_id="CCP43254.1"
/translation="MAGGMDQPPGQPRRRTRQQSSDGKNGVRAAEITGEIRALTGLRI
VAAVWVVLFHFRPMLGDASPGFRDALAPVLDCGAQGVDLFFILSGFVLTWNYLDRMGR
SWSVRANLHFLWLRLARVWPVYLVTLHLAAVWVIFTLHVGHVPSPEAGQLTAISYVRQ
ILLVQLWFQPYFDGSSWDGPAWSISAEWLAYLLFGLLILVIFRMKHATRARGLMWLAF
AASLPPVVLLLASGQFYTPWSWLPRIVTQFAAGALACAAVRRLRPTDRARRIAGYLSV
LVGVAIVGILYLLHAHPLAGVEDSGGVVDVLFVPLVISLAIGVGSLPALLSTRLMVFG
GQISFCLYMVHELVHTAWGWAVQQYELALQDQPWKWNVVGLLAIALGAAILLYHFVEE
PGRRWMRRMVDVKAASARSEPGEPVGSTRYQIDDALEGVSARAV"
gene 610188..610883
/locus_tag="Rv0518"
CDS 610188..610883
/codon_start=1
/transl_table=11
/locus_tag="Rv0518"
/product="Possible exported protein"
/note="Rv0518, (MTCY20G10.08), len: 231 aa. Possible
exported protein; has hydrophobic N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0518"
/db_xref="EnsemblGenomes-Tr:CCP43255"
/db_xref="InterPro:IPR013830"
/db_xref="InterPro:IPR036514"
/db_xref="UniProtKB/TrEMBL:O33363"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43255.1"
/translation="MSRPGTYVIGLTLLVGLVVGNPGCPRSYRPLTLDYRLNPVAVIG
DSYTTGTDEGGLGSKSWTARTWQMLAARGVRIAADVAAEGRAGYGVPGDHGNVFEDLT
ARAVQPDDALVVFFGSRNDQGMDPEDPEMLAEKVRDTFDLARHRAPSASLLVIAPPWP
TADVPGPMLRIRDVLGAQARAAGAVFVDPIADHWFVDRPELIGADGVHPNDAGHEYLA
DKIAPLISMELVG"
gene complement(611172..612074)
/locus_tag="Rv0519c"
CDS complement(611172..612074)
/codon_start=1
/transl_table=11
/locus_tag="Rv0519c"
/product="Possible conserved membrane protein"
/note="Rv0519c, (MTCY20G10.09c), len: 300 aa. Possible
conserved membrane protein, with hydrophobic region near
N-terminus. Could be a lipase. Similar to
Rv0774c|MTCY369.19c|A70708 from Mycobacterium tuberculosis
(312 aa), FASTA scores: opt: 1092, E(): 0, (57.9% identity
in 299 aa overlap). Contains PS00120 Lipases, serine
active site."
/db_xref="EnsemblGenomes-Gn:Rv0519c"
/db_xref="EnsemblGenomes-Tr:CCP43256"
/db_xref="GOA:O33364"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O33364"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43256.1"
/translation="MLRRGCAGNTDRRGIMTPMADLTRRALLRWGAGAGAGAAGVWAF
GALVDPLEPQAAPAPFEPPTAGSSLPTRISGSFISAARGGIKTNWVISMPPGQSGQLR
PVIALHGKDGNAGMMLDLGVEQGLARLVKEGKPAFAVVGVDGGNTYWHRRSSGGDSGA
MVLDELLPMLTSMGMDTSRVGFLGWSMGGYGALLLGARLGPARTAGICAISPALFTSF
TGSTPGAFDSYDDYVQHSVLGLPALNSIPLRVDCGTSDRFYFATRQFVNQLHQPPAGS
FSPGGHDASYWREQLPGELAWMAS"
gene 612255..612605
/locus_tag="Rv0520"
CDS 612255..612605
/codon_start=1
/transl_table=11
/locus_tag="Rv0520"
/product="Possible methyltransferase/methylase (fragment)"
/note="Rv0520, (MTCY20G10.10), len: 116 aa. Possible
fragment of methyltransferase (possibly first part),
highly similar to part of several methyltransferases e.g.
Q43445|U43683 S-adenosyl-L-methionine:DELTA24-sterol-C-
methyltransferase from Glycine max (Soybean)(367 aa),
FASTA scores: opt: 190,E(): 2.3e-12, (39.2% identity in 74
aa overlap). Also some similarity to MTCY19G5_5 from
Mycobacterium tuberculosis. Possibly continues as Rv0521
but we can find no frameshift to account for this."
/db_xref="EnsemblGenomes-Gn:Rv0520"
/db_xref="EnsemblGenomes-Tr:CCP43257"
/db_xref="GOA:O33365"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O33365"
/protein_id="CCP43257.1"
/translation="MGGCSITCLNISEVPNETNRKKNRQAGLDRSIRVIHGSFDDIPE
PDSGYDVVWSQDAILHAPDRRKVLEEAFRVLRPGGELIFTDPMQADDVPDGVLQPVYD
RLNLRDLGSMRFYA"
gene 612598..612903
/locus_tag="Rv0521"
CDS 612598..612903
/codon_start=1
/transl_table=11
/locus_tag="Rv0521"
/product="Possible methyltransferase/methylase (fragment)"
/note="Rv0521, (replaces MTCY20G10.11), len: 101 aa.
Possible fragment of methyltransferase (possibly second
part), highly similar to C-terminus of several
methyltransferases e.g. AAF87203.1|AF216282
sarcosine-dimethylglycine methyltransferase from
Halorhodospira halochloris (279 aa). Possibly continuation
of Rv0520 but we can find no frameshift to account for
this."
/db_xref="EnsemblGenomes-Gn:Rv0521"
/db_xref="EnsemblGenomes-Tr:CCP43258"
/db_xref="GOA:L7N6C0"
/db_xref="InterPro:IPR023143"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:L7N6C0"
/protein_id="CCP43258.1"
/translation="MREAAQALGFEVLDQRDLVRNLRTHYSRVFEELEARRLELEGKS
SQEYLDKMRVGLKNWVEAADNGHSRVGHPTFPRTRLTPICQLPTAAIDSTAGRRRYR"
gene 613038..614342
/gene="gabP"
/locus_tag="Rv0522"
CDS 613038..614342
/codon_start=1
/transl_table=11
/gene="gabP"
/locus_tag="Rv0522"
/product="Probable GABA permease GabP (4-amino butyrate
transport carrier) (GAMA-aminobutyrate permease)"
/note="Rv0522, (MTCY20G10.12), len: 434 aa. Probable
gabP,GABA permease (gamma-aminobutyrate permease),
integral membrane protein, highly similar to others e.g.
GABP_ECOLI|P25527 gaba permease from Escherichia coli (466
aa), FASTA scores: opt: 1218, E(): 0, (44.3% identity in
424 aa overlap); etc. Also similar to other M.
tuberculosis permeases e.g. MTCY13E10.06c FASTA score:
(34.4% identity in 407 aa overlap). Contains PS00218 Amino
acid permeases signature. Overlaps and extends
Rv0523c|MTCY25D10.01 from overlapping cosmid. Belongs to
the amino acid permease family (APC family)."
/db_xref="EnsemblGenomes-Gn:Rv0522"
/db_xref="EnsemblGenomes-Tr:CCP43259"
/db_xref="GOA:L7N6B9"
/db_xref="InterPro:IPR002293"
/db_xref="InterPro:IPR004840"
/db_xref="InterPro:IPR004841"
/db_xref="UniProtKB/TrEMBL:L7N6B9"
/inference="protein motif:PROSITE:PS00218"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43259.1"
/translation="MIAIGGVIGAGLFVGSGVVIRATGPAAFLTYALCGALIVLVMRM
LGEMAAANPSTGAFADYAAKALGGWAGFSVGWLYWYFWVIVVGFEAVAGGKVLTYWID
APLWLASLCLMMMMTATNLVSVSSFGEFEFWFAGVKVATIVGFLVLGTAFAFGLLPGH
GMDFSNLSAHGGFFPDGVGAVFAAIVVAIFSMTGTEVVTIAAAEAPDPQRAVQRAMST
VVARIVIFFVGSVFLLTVILPWNSLELGASPYVAALRHMGIGGADQIMNAVVLTAVLS
CLNSGLYTASRMLFVLAARQEAPAQLVKVNRRGVPTFAIMGSSVVGFLCVIMAWVSPA
TVFVFLLNSSGAVILFVYLLIALSQIVLRRQTSGQNLGVRMWLFPGLSIVTVTGIVAV
LARMAFDYAARSQLWLSLLSWAVVVGCYLVTTLVRRPLNRPW"
gene complement(614326..614721)
/locus_tag="Rv0523c"
CDS complement(614326..614721)
/codon_start=1
/transl_table=11
/locus_tag="Rv0523c"
/product="Conserved protein"
/note="Rv0523c, (MTCY25D10.02), len: 131 aa. Conserved
protein, showing some similarity to M. tuberculosis
proteins Rv1598c|MTCY336.06; and Rv1871c|MTCY336_06|O06592
(136 aa), FASTA scores: opt: 197, E(): 5e-08, (38.4%
identity in 99 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0523c"
/db_xref="EnsemblGenomes-Tr:CCP43260"
/db_xref="GOA:O06389"
/db_xref="InterPro:IPR004378"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/TrEMBL:O06389"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43260.1"
/translation="MQLPQWLARFNRYVTNPIQRLWAGWLPAFAILEHVGRRSGKPYR
TPLNVFSADVDGRAGVAILLTYGPNRDWLKNITAAGGGRMRRYGKTFGVANPRRLTKA
EAAPYVSSRWRPVFARLPFDEAVLLTKAD"
gene 614835..616223
/gene="hemL"
/locus_tag="Rv0524"
CDS 614835..616223
/codon_start=1
/transl_table=11
/gene="hemL"
/locus_tag="Rv0524"
/product="Probable glutamate-1-semialdehyde
2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde
aminotransferase) (GSA-at)"
/note="Rv0524, (MTCY25D10.03), len: 462 aa. Probable
hemL,glutamate-1-semialdehyde 2,1-aminomutase, equivalent
to P46716|GSA_MYCLE glutamate-1-semialdehyde
2,1-aminomutase from Mycobacterium leprae (446 aa), FASTA
scores: opt: 1532, E(): 0, (82.6% identity in 460 aa
overlap). Also highly similar to others e.g.
Q9F2S0|GSA_STRCO from Streptomyces coelicolor (438 aa);
Q06774|GSA_PROFR from Propionibacterium freudenreichii
(441 aa); etc. Contains PS00600 Aminotransferases
class-III pyridoxal-phosphate attachment site. Belongs to
class-III of pyridoxal-phosphate-dependent
aminotransferases. Cofactor: pyridoxal phosphate."
/db_xref="EnsemblGenomes-Gn:Rv0524"
/db_xref="EnsemblGenomes-Tr:CCP43261"
/db_xref="GOA:P9WMN9"
/db_xref="InterPro:IPR004639"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WMN9"
/inference="protein motif:PROSITE:PS00600"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43261.1"
/translation="MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVG
GTPRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFGAP
TPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHV
DALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDA
VQQTFARFGEQIAAVITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFR
VSRSGWYGIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNP
VAVAAGLATLRAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAGNMLSVFFGE
TPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSAALDDAAFGRIANALP
AAARAAAQERPA"
gene 616223..616831
/locus_tag="Rv0525"
CDS 616223..616831
/codon_start=1
/transl_table=11
/locus_tag="Rv0525"
/product="Conserved protein"
/note="Rv0525, (MTCY25D10.04), len: 202 aa. Conserved
protein, equivalent to Q49821|B2168_C3_276|S72912
hypothetical protein from Mycobacterium leprae (202
aa),FASTA scores: opt: 1151, E(): 0, (82.5% identity in
200 aa overlap). Also highly similar to
CAC08377.1|AL392176 putative phosphoglycerate mutase from
Streptomyces coelicolor (233 aa); and similar to
SLL0395|Q55734 hypothetical 23.8 kDa protein from
synechocystis SP. (212 aa), FASTA scores: opt: 207, E():
5.1e-07, (28.2% identity in 195 aa overlap). Also some
similarity to Rv2228c|Y019_MYCTU|Q10512|cy427.09
hypothetical 39.2 kDa protein from Mycobacterium
tuberculosis (364 aa), FASTA scores: opt: 236, E():
1.1e-08, (34.3% identity in 198 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0525"
/db_xref="EnsemblGenomes-Tr:CCP43262"
/db_xref="GOA:O06391"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="UniProtKB/Swiss-Prot:O06391"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43262.1"
/translation="MPEETQVHVVRHGEVHNPTGILYGRLPGFHLSATGAAQAAAVAD
ALADRDIVAVIASPLQRAQETAAPIAARHDLAVETDPDLIESANFFEGRRVGPGDGAW
RDPRVWWQLRNPFTPSWGEPYVDIAARMTTAVDKARVRGAGHEVVCVSHQLPVWTLRL
YLTGKRLWHDPRRRDCALASVTSLIYDGDRLVDVVYSQPAAL"
repeat_region 616828..616878
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 616846..617496
/locus_tag="Rv0526"
CDS 616846..617496
/codon_start=1
/transl_table=11
/locus_tag="Rv0526"
/product="Possible thioredoxin protein (thiol-disulfide
interchange protein)"
/note="Rv0526, (MTCY25D10.05), len: 216 aa. Possible
thioredoxin protein (thiol-disulfide interchange protein)
,equivalent to Q49816|U2168C|S72901 hypothetical protein
from Mycobacterium leprae (216 aa), FASTA scores: opt:
1144, E(): 0, (78.5% identity in 214 aa overlap).
C-terminus shows some similarity to C-terminus of
thioredoxins e.g. RESA_BACSU|P35160 resa protein from
Bacillus subtilis (181 aa), FASTA scores: opt: 200, E():
7.4e-06, (24.2% identity in 132 aa overlap); etc. Also
similar to Mycobacterium tuberculosis thioredoxin-like
proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194
Thioredoxin family active site. Seems to belong to the
thioredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv0526"
/db_xref="EnsemblGenomes-Tr:CCP43263"
/db_xref="GOA:O06392"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR017937"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:O06392"
/inference="protein motif:PROSITE:PS00194"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43263.1"
/translation="MQSRATRRSGALTMRRLVIAAAVSALLLTGCSGRDAVAQGGTFE
FVSPGGKTDIFYDPPASRGRPGPLSGPELADPARSVSLDDFPGQVVVVNVWGQWCGPC
RAEVSQLQRVYDATRGAGVSFLGIDVRDNNRQAPQDFINDRHVTYPSIYDPAMRTLIA
FGGKYPTSVIPSTLVLDRQHRVAAVFLRELLAADLQPVVERVAEEEPSGRAPVGAQ"
gene 617493..618272
/gene="ccdA"
/gene_synonym="ccsA"
/locus_tag="Rv0527"
CDS 617493..618272
/codon_start=1
/transl_table=11
/gene="ccdA"
/gene_synonym="ccsA"
/locus_tag="Rv0527"
/product="Possible cytochrome C-type biogenesis protein
CcdA"
/note="Rv0527, (MTCY25D10.06), len: 259 aa. Possible
ccdA,cytochrome C-type biogenesis protein, integral
membrane protein, equivalent to Q49810|B2168_C1_192|S72890
hypothetical protein from Mycobacterium leprae (262
aa),FASTA scores: opt: 1341, E(): 0, (79.0% identity in
262 aa overlap). Also highly similar to others e.g.
CAC08380.1 (253 aa); CCDA_BACSU|P45706 cytochrome C-type
biogenesis protein from Bacillus subtilis (235 aa), FASTA
scores: opt: 307, E(): 7.4e-13, (30.4% identity in 237 aa
overlap); etc. Seems to belong to the DSBD subfamily. Note
that previously known as ccsA."
/db_xref="EnsemblGenomes-Gn:Rv0527"
/db_xref="EnsemblGenomes-Tr:CCP43264"
/db_xref="GOA:L7N671"
/db_xref="InterPro:IPR003834"
/db_xref="UniProtKB/TrEMBL:L7N671"
/protein_id="CCP43264.1"
/translation="MTGFTEIAAVGPLLVAVGVCLLAGLVSFASPCVVPLVPGYLSYL
AAVVGVDEQLPAGVVKPPVAARWRVAGSAALFVAGFTTVFVLGTVAVLGMTTTLITNQ
LLLQRVGGVLIVVMGLVFVGFIGALQRQARFTPRQLTSVAGAPVLGAVFALGWTPCLG
PTLTGVITVASATEGASVARGIVLVIAYCLGLGIPFVLLAFGSAWAVAGLGWLRRHTR
AIQIFGGALLIAVGAALVTGVWNDVVSWLRDAFVSDVRLPI"
gene 618305..619894
/locus_tag="Rv0528"
CDS 618305..619894
/codon_start=1
/transl_table=11
/locus_tag="Rv0528"
/product="Probable conserved transmembrane protein"
/note="Rv0528, (MTCY25D10.07), len: 529 aa. Probable
conserved transmembrane protein, equivalent (shorter 14 aa
in N-terminus) to CAC31926.1|AL583925 conserved membrane
protein from Mycobacterium leprae (542 aa). Also highly
similar to Q49817|B2168_C2_237|S72902 hypothetical protein
from Mycobacterium leprae (364 aa), FASTA scores: opt:
1846, E(): 0, (81.1% identity in 338 aa overlap); and
Q49811|B2168_C1_194|S72891 hypothetical protein from
Mycobacterium leprae (106 aa), FASTA scores: opt: 506,
E(): 3.8e-26, (73.6% identity in 106 aa overlap). Also
highly similar to CAC08381.1|AL392176 putative integral
membrane protein from Streptomyces coelicolor (574 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0528"
/db_xref="EnsemblGenomes-Tr:CCP43265"
/db_xref="GOA:O06394"
/db_xref="InterPro:IPR007816"
/db_xref="UniProtKB/TrEMBL:O06394"
/protein_id="CCP43265.1"
/translation="MWRSLTSMGTALVLLFLLALAAIPGALLPQRGLNAAKVDDYLAA
HPLIGPWLDELQAFDVFSSFWFTAIYVLLFVSLVGCLAPRTIEHARSLRATPVAAPRN
LARLPKHAHARLAGEPAALAATITGRLRGWRSITRQQGDSVEVSAEKGYLREFGNLVF
HFALLGLLVAVAVGKLFGYEGNVIVIADGGPGFCSASPAAFDSFRAGNTVDGTSLHPI
CVRVNNFQAHYLPSGQATSFAADIDYQADPATADLIANSWRPYRLQVNHPLRVGGDRV
YLQGHGYAPTFTVTFPDGQTRTSTVQWRPDNPQTLLSAGVVRIDPPAGSYPNPDERRK
HQIAIQGLLAPTEQLDGTLLSSRFPALNAPAVAIDIYRGDTGLDSGRPQSLFTLDHRL
IEQGRLVKEKRVNLRAGQQVRIDQGPAAGTVVRFDGAVPFVNLQVSHDPGQSWVLVFA
ITMMAGLLVSLLVRRRRVWARITPTTAGTVNVELGGLTRTDNSGWGAEFERLTGRLLA
GFEARSPDMAEAAAGTGRDVD"
gene 619891..620865
/gene="ccsA"
/gene_synonym="ccsB"
/locus_tag="Rv0529"
CDS 619891..620865
/codon_start=1
/transl_table=11
/gene="ccsA"
/gene_synonym="ccsB"
/locus_tag="Rv0529"
/product="Possible cytochrome C-type biogenesis protein
CcsA"
/note="Rv0529, (MTCY25D10.08), len: 324 aa. Possible
ccsA,cytochrome C-type biogenesis protein, integral
membrane protein, equivalent to
NP_302558.1|NC_002677|B2168_C3_281 possible cytochrome C
biogenesis protein from Mycobacterium leprae (327 aa),
FASTA scores: opt: 1779, E(): 0, (82.9% identity in 327 aa
overlap). Also highly similar to others e.g.
CAC08382.1|AL392176 putative cytochrome biogenesis related
protein from Streptomyces coelicolor (380 aa);
CCSA_CHLRE|P48269 probable cytochrome c biogenesis protein
from Chlamydomonas reinhardtii (353 aa), FASTA scores:
opt: 449, E(): 1.3e-23, (34.4% identity in 247 aa
overlap); etc. Belongs to the CCMF/CYCK/CCL1/NRFE/CCSA
family. Note that previously known as ccsB."
/db_xref="EnsemblGenomes-Gn:Rv0529"
/db_xref="EnsemblGenomes-Tr:CCP43266"
/db_xref="GOA:O06393"
/db_xref="InterPro:IPR002541"
/db_xref="InterPro:IPR017562"
/db_xref="UniProtKB/TrEMBL:O06393"
/protein_id="CCP43266.1"
/translation="MNTLHVNVGLARYSDWAFTSAVVALVVALLLLAFEFAQVRGRGL
APLAVPAGSVATDSATPGIVADQRHRPFDERVGRGGLAVAYLGIGLLLACVVLRGLAT
QRVPWGNMYEFINLTCLSGLIAGAVVLRRARYRPLWVFLLVPVLILLTVSGRWLYANA
APVMPALQSYWLPIHVSVVSLGSGVFLVAGVASILFLVRTSRLGEPTGEGALAGMVRR
LPDAQTLDGIAYRTTIFAFPVFGFGVIFGAIWAEEAWGRYWGWDPKETVSFVAWVVYA
AYLHARSTAGWRDRKAAWINVAGFVAMVFNLFFVNLVTVGLHSYAGVG"
gene 620907..622124
/locus_tag="Rv0530"
CDS 620907..622124
/codon_start=1
/transl_table=11
/locus_tag="Rv0530"
/product="Conserved protein"
/note="Rv0530, (MTCY25D10.09), len: 405 aa. Conserved
protein, similar in part to other hypothetical proteins
e.g. AL031231|SC3C3_3|CAA20252.1 from Streptomyces
coelicolor (1083 aa), FASTA scores: opt: 870, E():
0,(39.5% identity in 443 aa overlap); etc. Also similar to
Mycobacterium tuberculosis proteins e.g. Rv3868,
Rv0282,Rv1798, etc."
/db_xref="EnsemblGenomes-Gn:Rv0530"
/db_xref="EnsemblGenomes-Tr:CCP43267"
/db_xref="GOA:O06396"
/db_xref="InterPro:IPR002586"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O06396"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43267.1"
/translation="MLVTEHPRTGVGAPDSGNGGTDHPTVQLPPVPSVGAPPAAAGGE
TPTRSVAGFRTQRLDPTAYGAYYSGPDEGPASPAERPPYRLEPVPHTPYPELATTTLL
RPVKPPPSEGWRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKG
GVGKTTITATLGATFADLRGDRVVAVDANPDRGTLSQKVPLETPATVRHLLRDADGIE
RYSDVRGYTSKGPSGLEVLASDSDPASSDAFSADDYTRTLDILERFYGLVLTDCGTGL
LHSAMSAVLPRSDVLVVVSSGSIDGARSAAATLDWLQAHGHDDQVRNSIAVVNAVRPR
AGKVDVGKVVEHFSRRCRAVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAG
FPGDPRRCKPSFT"
gene complement(622121..622282)
/locus_tag="Rv0530A"
CDS complement(622121..622282)
/codon_start=1
/transl_table=11
/locus_tag="Rv0530A"
/product="Conserved protein"
/note="Rv0530A, len: 53 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv0530A"
/db_xref="EnsemblGenomes-Tr:CCP43268"
/db_xref="UniProtKB/TrEMBL:V5QPR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43268.1"
/translation="MLYLLLVLILATLIYLGWRAARAQMNRPKTRVIGPDDDPEFLRR
LGHGDNNRS"
gene 622329..622646
/locus_tag="Rv0531"
CDS 622329..622646
/codon_start=1
/transl_table=11
/locus_tag="Rv0531"
/product="Possible conserved membrane protein"
/note="Rv0531, (MTCY25D10.10), len: 105 aa. Possible
conserved membrane protein, highly similar to
Y13803|MLB1306_1|CAA74131.1 hypothetical protein from
Mycobacterium leprae (86 aa), FASTA scores: E():
2.1e-24,(74.4% identity in 86 aa overlap); and
NP_302557.1|NC_002677 putative membrane protein from
Mycobacterium leprae (111 aa). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0531"
/db_xref="EnsemblGenomes-Tr:CCP43269"
/db_xref="GOA:O06397"
/db_xref="InterPro:IPR025323"
/db_xref="UniProtKB/TrEMBL:O06397"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43269.1"
/translation="MSEAPNDKTTRGVVDILVYATARLLLVVAVSAAIFGVARLIGLT
EFPVVVATLFGLIIAMPLGIWVFSPLRRRATAALAVAGERRRAERERLRARLRGESLP
EEQ"
gene 622793..624577
/gene="PE_PGRS6"
/locus_tag="Rv0532"
CDS 622793..624577
/codon_start=1
/transl_table=11
/gene="PE_PGRS6"
/locus_tag="Rv0532"
/product="PE-PGRS family protein PE_PGRS6"
/note="Rv0532, (MTCY25D10.11), len: 594 aa.
PE_PGRS6,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below),similar to others e.g. Y0DP_MYCTU|Q50615 from
Mycobacterium tuberculosis (498 aa), FASTA scores: opt:
1703, E(): 0,(58.2% identity in 536 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0532"
/db_xref="EnsemblGenomes-Tr:CCP43270"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L0T3X8"
/protein_id="CCP43270.1"
/translation="MSNLLVTPELVAAAAADLAGIGSAIGAANAAAGAPTMALLAAGA
DEVSAAVAAVFSSYAQQYQALSAAAAAFHDQFVRALAAGAGAYAGAEAANVEQQLLNA
INAPTLALLGRPLIGNGADGAAGTGQAGGAGGLLYGNGGNGGSGAAGQAGGAGGAAGL
IGHGGTGGAVTGVSTTGGPGGHGGDAGLYGFGGAGGAGGFGQSGAAGGAGGAGGWLYG
DGGDGGAGDNGGNESGTGVSAVGGVGGAGGAGGLLFGNGGDGGVGGDGGDGSSTQDSG
GDGGAGGAGGAGGWLLGNGGAGGAGGAASIKVATGGLGGDGGDAGLFGFGGDGGWGGR
GVDARFGAAGGAAGAGGAGGWLYGDGGAGGVGGVGGAVFSLSSGDGGAGGAGGGGGWL
FGNGGDGGAGGGGGGRFGSGSGAGGDGAVGGAGGAGAWFGNGGAGGVGGGGGRGTTAI
GGDGGAGGAGGAGGWLYGDGGAGGAGGGGGRGGTGNDGGDGGDGGRGGDAQLLGNGGD
GGAGGAGGPAGLALPPGPARPAGAAVPAVRCSAAPARPARTADPWLAPIFARSTLRHS
HHLGGIAQTGAVADQQGQIAGLGRAGRQ"
gene complement(624473..625480)
/gene="fabH"
/gene_synonym="mtFabH"
/locus_tag="Rv0533c"
CDS complement(624473..625480)
/codon_start=1
/transl_table=11
/gene="fabH"
/gene_synonym="mtFabH"
/locus_tag="Rv0533c"
/product="3-oxoacyl-[acyl-carrier-protein] synthase III
FabH (beta-ketoacyl-ACP synthase III) (KAS III)"
/note="Rv0533c, (MTCY25D10.12c), len: 335 aa. FabH
(alternate gene name: mtFabH), 3-oxoacyl-[acyl-carrier
protein] synthase III (see citations below), highly
similar to others e.g. Q54206|FABH from streptomyces
glaucescens (333 aa), FASTA scores: opt: 1109, E(): 0,
(51.4% identity in 333 aa overlap); FABH_ECOLI|P24249
3-oxoacyl-[acyl-carrier-protein] synthase III (317
aa),FASTA scores: opt: 666, E(): 0, (37.1% identity in 318
aa overlap); etc. Belongs to the FabH family."
/db_xref="EnsemblGenomes-Gn:Rv0533c"
/db_xref="EnsemblGenomes-Tr:CCP43271"
/db_xref="GOA:P9WNG3"
/db_xref="InterPro:IPR004655"
/db_xref="InterPro:IPR013747"
/db_xref="InterPro:IPR013751"
/db_xref="InterPro:IPR016039"
/db_xref="PDB:1HZP"
/db_xref="PDB:1M1M"
/db_xref="PDB:1U6E"
/db_xref="PDB:1U6S"
/db_xref="PDB:2AHB"
/db_xref="PDB:2AJ9"
/db_xref="PDB:2QNX"
/db_xref="PDB:2QNY"
/db_xref="PDB:2QNZ"
/db_xref="PDB:2QO0"
/db_xref="PDB:2QO1"
/db_xref="PDB:2QX1"
/db_xref="UniProtKB/Swiss-Prot:P9WNG3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43271.1"
/translation="MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIY
TRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAP
MVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYD
RGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPF
VRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRP
DAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPK
G"
gene complement(625562..626440)
/gene="menA"
/locus_tag="Rv0534c"
CDS complement(625562..626440)
/codon_start=1
/transl_table=11
/gene="menA"
/locus_tag="Rv0534c"
/product="1,4-dihydroxy-2-naphthoate octaprenyltransferase
MenA (DHNA-octaprenyltransferase)"
/note="Rv0534c, (MTCY25D10.13c), len: 292 aa. Probable
menA, 1,4-dihydroxy-2-naphthoate
octaprenyltransferase,integral membrane protein,
equivalent to Y13803|MLB1306_2|NP_302556.1 probable
4-dihydroxy-2-naphthoate octaprenyltransferase from
Mycobacterium leprae (294 aa), FASTA scores: opt:
1509,E(): 0, (80.2% identity in 288 aa overlap). Also
highly similar to others e.g. MENA_ECOLI|P32166|B3930 from
Escherichia coli (308 aa), FASTA scores: opt: 495, E():
2.9e-25, (36.3 identity in 289 aa overlap); etc. Belongs
to the MenA family."
/db_xref="EnsemblGenomes-Gn:Rv0534c"
/db_xref="EnsemblGenomes-Tr:CCP43272"
/db_xref="GOA:P9WIP3"
/db_xref="InterPro:IPR000537"
/db_xref="InterPro:IPR004657"
/db_xref="InterPro:IPR026046"
/db_xref="UniProtKB/Swiss-Prot:P9WIP3"
/protein_id="CCP43272.1"
/translation="MASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLA
LAVAVALVIGVNYANDYSDGIRGTDDDRVGPVRLVGSRLATPRSVLTAAMTSLALGAL
AGLVLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQY
TQALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQ
GLLAVAGVLTFVLMLATPWCVVGLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAML
VWALAVAGALAFGQLS"
gene 626457..627251
/gene="pnp"
/locus_tag="Rv0535"
CDS 626457..627251
/codon_start=1
/transl_table=11
/gene="pnp"
/locus_tag="Rv0535"
/product="Probable 5'-methylthioadenosine phosphorylase
Pnp (MTA phosphorylase)"
/note="Rv0535, (MTCY25D10.14c), len: 264 aa. Probable
pnp,5'-methylthioadenosine phosphorylase, highly similar
to others e.g. CAB90972.1|AL355832 putative
methylthioadenosine phosphorylase from Streptomyces
coelicolor (280 aa); etc. Also similar to Rv3307|deoD
probable purine nucleoside phosphorylase from
Mycobacterium tuberculosis (268 aa). Belongs to the
PNP/MTAP family 2 of phosphorylases. Gene name could be
inappropriate."
/db_xref="EnsemblGenomes-Gn:Rv0535"
/db_xref="EnsemblGenomes-Tr:CCP43273"
/db_xref="GOA:O06401"
/db_xref="InterPro:IPR000845"
/db_xref="InterPro:IPR010044"
/db_xref="InterPro:IPR035994"
/db_xref="UniProtKB/Swiss-Prot:O06401"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43273.1"
/translation="MHNNGRMLGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGT
IGVHDVAFLPRHGAHHQYSAHAVPYRANMWALRALGVRRVFGPCAVGSLDPELEPGAV
VVPDQLVDRTSGRADTYFDFGGVHAAFADPYCPTLRAAVTGLPGVVDGGTMVVIQGPR
FSTRAESQWFAAAGCNLVNMTGYPEAVLARELELCYAAIALVTDVDAGVAAGDGVKAA
DVFAAFGENIELLKRLVRAAIDRVADERTCTHCQHHAGVPLPFELP"
gene 627248..628288
/gene="galE3"
/gene_synonym="galE2"
/locus_tag="Rv0536"
CDS 627248..628288
/codon_start=1
/transl_table=11
/gene="galE3"
/gene_synonym="galE2"
/locus_tag="Rv0536"
/product="Probable UDP-glucose 4-epimerase GalE3
(galactowaldenase) (UDP-galactose 4-epimerase) (uridine
diphosphate galactose 4-epimerase) (uridine
diphospho-galactose 4-epimerase)"
/note="Rv0536, (MTCY25D10.15), len: 346 aa. Possible
galE3,UDP-glucose 4-epimerase, highly similar to
CAB76986.1|AL159178 putative epimerase from Streptomyces
coelicolor (334 aa); and similar to other epimerases e.g.
NP_436775.1|NC_003078 putative NDP-glucose
dehydrataseepimerase protein from Sinorhizobium meliloti
(368 aa); AF143772|AF143772_7 GepiA from Mycobacterium
avium strain 2151 (353 aa), FASTA scores: opt: 577, E():
3.9e-29, (36.6% identity in 352 aa overlap);
GALE_METJA|Q57664 putative UDP-glucose 4-epimerase (305
aa), FASTA scores: opt: 300, E(): 1.6e-12, (30.9% identity
in 343 aa overlap); etc. Also similar to Mycobacterium
tuberculosis proteins e.g. Rv3634c, Rv3784, etc. Seems to
belong to the sugar epimerase family. Note that previously
known as galE2."
/db_xref="EnsemblGenomes-Gn:Rv0536"
/db_xref="EnsemblGenomes-Tr:CCP43274"
/db_xref="GOA:L7N670"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:L7N670"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43274.1"
/translation="MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHGPNPVL
PPGCQRVDVRDASALAPLLAGVDLVCHQAAMVGAGVNAADAPAYGGHNDFATTVLLAQ
MFAAGVRRLVLASSMVVYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVI
WQLVDEDAPLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMPRDTPYS
GVAAIFRSAVEKGKPPKVFEDGGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVC
SGRPISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLGFRAAVDPG
EGLREFAFAPLR"
gene complement(628298..629731)
/locus_tag="Rv0537c"
CDS complement(628298..629731)
/codon_start=1
/transl_table=11
/locus_tag="Rv0537c"
/product="Probable integral membrane protein"
/note="Rv0537c, (MTCY25D10.16c), len: 477 aa. Probable
integral membrane protein, showing weak similarity to
YDNK_STRCO|P40180 hypothetical 41.2 kDa protein from
Streptomyces coelicolor (411 aa), FASTA scores: opt:
122,E(): 0.85, (28.2% identity in 373 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0537c"
/db_xref="EnsemblGenomes-Tr:CCP43275"
/db_xref="GOA:O06403"
/db_xref="UniProtKB/TrEMBL:O06403"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43275.1"
/translation="MGLSSDDTRRREVVRDLAAGALLIGALFFPWNLYFGFRIPDSSK
TVFGLLLAVTSLSLASLAVTFAGRRSQLRLGLNVPYLLLVLAFVVFDAIQTIRLGGTV
HVPGGVGPGGWLGITGALLSAQPALTGATTDEGSHSRWLRATQFLGYASMLGAALSTG
FNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYGVVALAAVLVASRWLLRPTAAEAL
STVALGGSTLIAGSIVWSLPIGREIDAFHGIAQNTSTAGVGYEGYLVWAAAAAMCAPL
TLFRSPNAPPIDKTVWRAASRNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSM
ALAAFDLATAVLAIWLRFNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRFQAS
SGGSAHPVYGNDLAQQITSTFDVVLCGLALSILAAAIVIGRLRQLPQPPHTPALSRPA
GSPRIFRSAGSTHPVRPKIYRPPDHSS"
gene 630040..631686
/locus_tag="Rv0538"
CDS 630040..631686
/codon_start=1
/transl_table=11
/locus_tag="Rv0538"
/product="Possible conserved membrane protein"
/note="Rv0538, (MTCY25D10.17), len: 548 aa. Possible
conserved membrane protein. Middle region highly similar
to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein
from Mycobacterium bovis (295 aa) possible transmembrane
protein with a repetitive proline, threonine-rich region
at C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0538"
/db_xref="EnsemblGenomes-Tr:CCP43276"
/db_xref="GOA:O06404"
/db_xref="UniProtKB/TrEMBL:O06404"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43276.1"
/translation="MDVALGVAVTDRVARLALVDSAAPGTVIDQFVLDVAEHPVEVLT
ETVVGTDRSLAGENHRLVATRLCWPDQAKADELQHALQDSGVHDVAVISEAQAATALV
GAAHAGSAVLLVGDETATLSVVGDPDAPPTMVAVAPVAGADATSTVDTLMARLGDQAL
APGDVFLVGRSAEHTTVLADQLRAASTMRVQTPDDPTFALARGAAMAAGAATMAHPAL
VADATTSLPRAEAGQSGSEGEQLAYSQASDYELLPVDEYEEHDEYGAAADRSAPLSRR
SLLIGNAVVAFAVIGFASLAVAVAVTIRPTAASKPVEGHQNAQPGKFMPLLPTQQQAP
VPPPPPDDPTAGFQGGTIPAVQNVVPRPGTSPGVGGTPASPAPEAPAVPGVVPAPVPI
PVPIIIPPFPGWQPGMPTIPTAPPTTPVTTSATTPPTTPPTTPVTTPPTTPPTTPVTT
PPTTPPTTPVTTPPTTVAPTTVAPTTVAPTTVAPTTVAPATATPTTVAPQPTQQPTQQ
PTQQMPTQQQTVAPQTVAPAPQPPSGGRNGSGGGDLFGGF"
gene 631743..632375
/locus_tag="Rv0539"
CDS 631743..632375
/codon_start=1
/transl_table=11
/locus_tag="Rv0539"
/product="Probable dolichyl-phosphate sugar synthase
(dolichol-phosphate sugar synthetase) (dolichol-phosphate
sugar transferase) (sugar phosphoryldolichol synthase)"
/note="Rv0539, (MTCY25D10.18), len: 210 aa. Probable
dolichol-P-sugar synthase, highly similar to
CAB76989.1|AL159178 putative glycosyltransferase from
Streptomyces coelicolor (242 aa), and similar to various
dolichol-P-sugar synthetases and sugar transferases e.g.
NP_126257.1|NC_000868 dolichyl-phosphate mannose synthase
related protein from Pyrococcus abyssi (211 aa);
N-terminus of NP_127133.1|NC_000868 dolichol-P-glucose
synthetase from Pyrococcus abyssi (378 aa); N-terminus of
NP_068880.1|NC_000917 putative dolichol-P-glucose
synthetase from Archaeoglobus fulgidus (369 aa), FASTA
scores: E(): 2.4e-13, (32. 1% identity in 193 aa overlap);
Q26732 dolichyl-phosphate-mannose synthase precursor from
trypanosoma brucei (267 aa), FASTA scores: opt: 179, E():
0.0011, (30.7% identity in 205 aa overlap); etc. Also
similar to Rv2051c|MTY25D10_18 from Mycobacterium
tuberculosis. Contains PS00017 ATP/GTP-binding site motif
A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0539"
/db_xref="EnsemblGenomes-Tr:CCP43277"
/db_xref="GOA:P9WMY1"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WMY1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43277.1"
/translation="MLPCLNEEESLPAVLAAIPAGYRALVVDNNSTDDTATVAARHGA
QVVVEPRPGYGSAVHAGVLAATTPIVAVIDADGSMDAGDLPKLVAELDKGADLVTGRR
RPVAGLHWPWVARVGTVVMSWRLRTRHRLPVHDIAPMRVARREALLDLGVVDRRSGYP
LELLVRAAAAGWRVVELDVSYGPRTGGKSKVSGSLRGSIIAILDFWKVIS"
gene 632372..633034
/locus_tag="Rv0540"
CDS 632372..633034
/codon_start=1
/transl_table=11
/locus_tag="Rv0540"
/product="Conserved hypothetical protein"
/note="Rv0540, (MTCY25D10.19), len: 220 aa. Conserved
hypothetical protein, similar to hypothetical proteins
from Streptomyces coelicolor: CAB76990.1|AL159178 (213
aa); N-terminus of BAA84086.1|AB032065 (446 aa); and
CAB61872.1|AL133252|SCE46_21 (210 aa), FASTA scores: opt:
267, E(): 5.3e-10, (32.7% identity in 202 aa overlap).
Also some similarity with D90913_63|PCC6803 from Synecho
cystis sp (211 aa), FASTA scores: opt: 189, E(): 4.7e-06,
(25.3 identity in 194 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0540"
/db_xref="EnsemblGenomes-Tr:CCP43278"
/db_xref="GOA:O06406"
/db_xref="InterPro:IPR018641"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:O06406"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43278.1"
/translation="MSCLPVSVLVVAKAPEPGRVKTRLAAAIGDKVAADIAAAALLDT
LDAVAAAPVTARAVALTGDLDSAADSAEIRRRLKSFTVFRQRGDAFADRLANAHVDAA
DGYPVLQIGMDTPQVTAELLADCARLLLQIPAVLGLAFDGGWWVLGIRTPTAAECLRA
VPMSQPDTGELTLKALRDNGIDVTLVQRLGDFDIVDDIALVRDCCAPGSRFAQATRAA
GL"
gene complement(633055..634404)
/locus_tag="Rv0541c"
CDS complement(633055..634404)
/codon_start=1
/transl_table=11
/locus_tag="Rv0541c"
/product="Probable conserved integral membrane protein"
/note="Rv0541c, (MTCY25D10.20c), len: 449 aa. Probable
conserved integral membrane protein, highly similar
(except first 40 residues) to CAB76994.1|AL159178 putative
integral membrane protein from Streptomyces coelicolor
(456 aa). Also some similarity to Q13724|GCS1_HUMAN
mannosyl-oligosaccharide glucosidase (834 aa), FASTA
scores: opt: 150, E(): 0.013, (27.1% identity in 339 aa
overlap). Contains PS00041 Bacterial regulatory
proteins,araC family signature."
/db_xref="EnsemblGenomes-Gn:Rv0541c"
/db_xref="EnsemblGenomes-Tr:CCP43279"
/db_xref="GOA:O06407"
/db_xref="UniProtKB/TrEMBL:O06407"
/inference="protein motif:PROSITE:PS00041"
/protein_id="CCP43279.1"
/translation="MRIGRREGLAVAIGFVLVGAAFVLPRLNLGIKPRSDIGLERFAT
RAGAAPIFGYWDAHVGWGTAPAVLTAVAVVAWGPVVAHRLPWRVLTLSTWATAAAWAF
SLAMIDGWQRGFAGRLTTRDEYLWQVPGIADIPATLRTFTSRILDFQPNSWVTHVSGH
PPGALLTFVWLDRIGLRGGGWAGLVCLLVGSSAAAAVLIAVRVLASEQMARRTAPFVA
VAPTAIWIAVSADGYFAGVAAWGIALLAVAVHGATRFPALVAAGAGLLLGWGVFLNYG
LVLIVLPGMAVLAAADWRPVLRALGPAVLAALVVAVSFAVAGFSWFDGYTLVQQRYWQ
GIAKDRPFGYWSWANLACVVCAIGLGSVAGLSRVFDRAAISRRSGCHLLLLAVLAAIA
LADLSMLSKAETERIWLPFTIWLTAAPALLPPRSHRLWLAVNAAGALLLNSIIFTNW"
gene complement(634416..635504)
/gene="menE"
/locus_tag="Rv0542c"
CDS complement(634416..635504)
/codon_start=1
/transl_table=11
/gene="menE"
/locus_tag="Rv0542c"
/product="Possible O-succinylbenzoic acid--CoA ligase MenE
(OSB-CoA synthetase) (O-succinylbenzoate-CoA synthase)"
/note="Rv0542c, (MTCY25D10.21c), len: 362 aa. Possible
menE, O-succinylbenzoic acid-CoA ligase, highly similar to
Q50170|AAA63145.1|U15187|XCLB 4-Coumarate--CoA ligase from
Mycobacterium leprae (352 aa), FASTA scores: opt:
1815,E(): 0, (78.9% identity in 351 aa overlap). Also
similar to N-terminus of acid-CoA ligases e.g.
NP_471116.1|NC_003212 O-succinylbenzoic acid-CoA ligase
from Listeria innocua (469 aa); NP_390957.1|NC_000964
O-succinylbenzoic acid-CoA ligase from Bacillus subtilis
(486 aa); MENE_HAEIN|P44565 O-succinylbenzoic acid-CoA
ligase from Haemophilus influenzae (452 aa), FASTA scores:
opt: 307, E(): 4.6e-12,(25.4% identity in 339 aa overlap);
etc. Also some similarity with fadD proteins from
Mycobacterium tuberculosis. Contains PS00455 Putative
AMP-binding domain signature. Belongs to the ATP-dependent
AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv0542c"
/db_xref="EnsemblGenomes-Tr:CCP43280"
/db_xref="GOA:P9WQ39"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ39"
/inference="protein motif:PROSITE:PS00455"
/protein_id="CCP43280.1"
/translation="MLGGSDPALVAVPTQHESLLGALRVGEQIDDDVALVVTTSGTTG
PPKGAMLTAAALTASASAAHDRLGGPGSWLLAVPPYHIAGLAVLVRSVIAGSVPVELN
VSAGFDVTELPNAIKRLGSGRRYTSLVAAQLAKALTDPAATAALAELDAVLIGGGPAP
RPILDAAAAAGITVVRTYGMSETSGGCVYDGVPLDGVRLRVLAGGRIAIGGATLAKGY
RNPVSPDPFAEPGWFHTDDLGALESGDSGVLTVLGRADEAISTGGFTVLPQPVEAALG
THPAVRDCAVFGLADDRLGQRVVAAIVVGDGCPPPTLEALRAHVARTLDVTAAPRELH
VVNVLPRRGIGKVDRAALVRRFAGEADQ"
gene complement(635573..635875)
/locus_tag="Rv0543c"
CDS complement(635573..635875)
/codon_start=1
/transl_table=11
/locus_tag="Rv0543c"
/product="Conserved protein"
/note="Rv0543c, (MTCY25D10.22c), len: 100 aa. Conserved
protein, equivalent to
Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved
hypothetical protein from Mycobacterium leprae (100
aa),FASTA scores: opt: 493, E(): 6.1e-30, (73.5% identity
in 98 aa overlap). Some similarity to Rv3046c|NP_217562.1
from Mycobacterium tuberculosis. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al.,2004). Alternative nucleotide at position 635633
(C->T; A81A) has been observed."
/db_xref="EnsemblGenomes-Gn:Rv0543c"
/db_xref="EnsemblGenomes-Tr:CCP43281"
/db_xref="InterPro:IPR021784"
/db_xref="UniProtKB/TrEMBL:O06409"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43281.1"
/translation="MNRFLTSIVAWLRAGYPEGIPPTDSFAVLALLCRRLSHDEVKAV
ANELMRLGDFDQIDIGVVITHFTDELPSPEDVERVRARLAAQGWPLDDVRDREEHA"
gene complement(635935..636213)
/locus_tag="Rv0544c"
CDS complement(635935..636213)
/codon_start=1
/transl_table=11
/locus_tag="Rv0544c"
/product="Possible conserved transmembrane protein"
/note="Rv0544c, (MTCY25D10.23c), len: 92 aa. Possible
conserved transmembrane protein, equivalent to
NP_302470.1|NC_002677 possible membrane protein from
Mycobacterium leprae (96 aa); and shows some similarity to
MLU15187_33|Q50172|U296V from Mycobacterium leprae (36
aa),FASTA scores: opt: 151, E(): 2.1e-05, (71.4% identity
in 35 aa overlap). Also some similarity with
VATL_NEPNO|Q26250 vacuolar ATP synthase 16 kDa proteolipid
from Nephrops norvegicus (159 aa), FASTA scores: opt: 80,
E(): 11, (26.1% identity in 88 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0544c"
/db_xref="EnsemblGenomes-Tr:CCP43282"
/db_xref="GOA:O06410"
/db_xref="UniProtKB/TrEMBL:O06410"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43282.1"
/translation="MSAWFNYTATLKILIFSLLAGALLPGLFAVGVRLQAAGDGADAT
ARRRPLLVAVSWAIFALVLAVVIIGVLYIARDFIAHHTGWAFLGATPK"
gene complement(636210..637463)
/gene="pitA"
/locus_tag="Rv0545c"
CDS complement(636210..637463)
/codon_start=1
/transl_table=11
/gene="pitA"
/locus_tag="Rv0545c"
/product="Probable low-affinity inorganic phosphate
transporter integral membrane protein PitA"
/note="Rv0545c, (MTCY25D10.24c), len: 417 aa. Probable
pitA, low-affinity inorganic phosphate
transporter,integral membrane protein, equivalent to
Q50173|NP_302471.1 pitA from Mycobacterium leprae (414
aa), FASTA scores: opt: 2035, E(): 0, (76.3% identity in
418 aa overlap). Also highly similar to others e.g.
CAB59461.1|AL132644 putative low-affinity phosphate
transport protein from Streptomyces coelicolor (423 aa);
PITA_ECOLI|P37308 low-affinity inorganic phosphate
transporter from Escherichia coli (499 aa), FASTA scores:
opt: 304, E(): 6.9e-10, (32.5 % identity in 234 aa
overlap); etc. Belongs to the PHO-4 family of
transporters, pit subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0545c"
/db_xref="EnsemblGenomes-Tr:CCP43283"
/db_xref="GOA:P9WIA7"
/db_xref="InterPro:IPR001204"
/db_xref="UniProtKB/Swiss-Prot:P9WIA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43283.1"
/translation="MNLQLFLLLIVVVTALAFDFTNGFHDTGNAMATSIASGALAPRV
AVALPAVLNLIGAFLSTAVAATIAKGLIDANLVTLELVFAGLVGGIVWNLLTWLLGIP
SSSSHALIGGIVGATIAAVGLRGVIWSGVVSKVIVPAVVAALLATLVGAVGTWLVYRT
TRGVAEKRTERGFRRGQIGSASLVSLAHGTNDAQKTMGVIFLALMSYGAVSTTASVPP
LWVIVSCAVAMAAGTYLGGWRIIRTLGKGLVEIKPPQGMAAESSSAAVILLSAHFGYA
LSTTQVATGSVLGSGVGKPGAEVRWGVAGRMVVAWLVTLPLAGLVGAFTYGLVHFIGG
YPGAILGFALLWLTATAIWLRSRRAPIDHTNVNADWEGNLTAGLEAGAQPLADQRPPV
PAPPAPTPPPNHRAPQFGVTTRNAP"
gene complement(637583..637969)
/locus_tag="Rv0546c"
CDS complement(637583..637969)
/codon_start=1
/transl_table=11
/locus_tag="Rv0546c"
/product="Conserved protein"
/note="Rv0546c, (MTCY25D10.25c), len: 128 aa. Conserved
protein, equivalent to AAA63111.1|U15187|Q50174|U296X
hypothetical protein from Mycobacterium leprae (144
aa),FASTA scores: opt: 748, E(): 0, (84.2% identity in 133
aa overlap). Also highly similar to CAB95979.1|AL360034
conserved hypothetical protein from Streptomyces
coelicolor (130 aa); and similar to AE000854_8|O26852
S-D-lactoylglutathione methylglyoxal lyase from
Methanobacterium thermoautotropto (116 aa), FASTA scores:
opt: 155, E(): 0.00019, (30.6% identity in 108 aa
overlap); YAER_ECOLI hypothetical 14.7 kDa protein from
Escherichia coli (129 aa), FASTA scores: opt: 104, E():
0.42, (28.7% identity in 115 aa overlap). Also similar to
Rv2068c from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0546c"
/db_xref="EnsemblGenomes-Tr:CCP43284"
/db_xref="InterPro:IPR004360"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="UniProtKB/TrEMBL:O06412"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43284.1"
/translation="MEILASRMLLRPADYQRSLSFYRDQIGLAIAREYGAGTVFFAGQ
SLLELAGYGEPDHSRGPFPGALWLQVRDLEATQTELVSRGVSIAREPRREPWGLHEMH
VTDPDGITLIFVEVPEGHPLRTDTRA"
gene complement(638032..638916)
/locus_tag="Rv0547c"
CDS complement(638032..638916)
/codon_start=1
/transl_table=11
/locus_tag="Rv0547c"
/product="Possible oxidoreductase"
/note="Rv0547c, (MTCY25D10.26c), len: 294 aa. Possible
oxidoreductase, similar to various oxidoreductases e.g.
fatty acyl-CoA reductase from Acinetobacter calcoaceticus
(295 aa); NP_280196.1|NC_002607
3-oxoacyl-[acyl-carrier-protein] reductase from
Halobacterium sp. NRC-1 (255 aa); NP_349214.1|NC_003030
Short-chain alcohol dehydrogenase family protein from
Clostridium acetobutylicum (255 aa); etc. Also similar to
several proteins from Mycobacterium tuberculosis e.g.
Y04M_MYCTU|Q10783 putative oxidoreductase (341 aa), FASTA
scores: opt: 644, E(): 0, (46.1% identity in 258 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0547c"
/db_xref="EnsemblGenomes-Tr:CCP43285"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O06413"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43285.1"
/translation="MSKRPLRWLTEQITLAGMRPPISPQLLINRPAMQPVDLTGKRIL
LTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDME
AIDALVEDVEKRIGGIDILINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRG
LAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAALSAVSRIIETEWGSQGVHST
TLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSI
GPRWVNALMQRRNEQLNP"
gene complement(639012..639956)
/gene="menB"
/locus_tag="Rv0548c"
CDS complement(639012..639956)
/codon_start=1
/transl_table=11
/gene="menB"
/locus_tag="Rv0548c"
/product="Naphthoate synthase MenB (dihydroxynaphthoic
acid synthetase) (DHNA synthetase)"
/note="Rv0548c, (MTCY25D10.27c), len: 314 aa.
menB,naphthoate synthase (dihydroxynaphthonic acid
synthase),equivalent to NP_302473.1|NC_002677 naphthoate
synthase from Mycobacterium leprae (300 aa). Also similar
to others e.g. MENB_ECOLI|P27290 naphthoate synthase from
Escherichia coli (285 aa), FASTA scores: opt: 599, E():
9.3e-33, (48.1 identity in 285 aa overlap); etc. Belongs
to the enoyl-CoA hydratase/isomerase family."
/db_xref="EnsemblGenomes-Gn:Rv0548c"
/db_xref="EnsemblGenomes-Tr:CCP43286"
/db_xref="GOA:P9WNP5"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR010198"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR029045"
/db_xref="PDB:1Q51"
/db_xref="PDB:1Q52"
/db_xref="PDB:1RJM"
/db_xref="PDB:1RJN"
/db_xref="PDB:3T8A"
/db_xref="PDB:3T8B"
/db_xref="PDB:4QII"
/db_xref="PDB:4QIJ"
/db_xref="UniProtKB/Swiss-Prot:P9WNP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43286.1"
/translation="MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVD
DATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFC
SGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAG
GGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRT
YTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQ
LFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF"
gene complement(640228..640641)
/gene="vapC3"
/locus_tag="Rv0549c"
CDS complement(640228..640641)
/codon_start=1
/transl_table=11
/gene="vapC3"
/locus_tag="Rv0549c"
/product="Possible toxin VapC3"
/note="Rv0549c, (MTCY25D10.28c), len: 137 aa. Possible
vapC3, toxin, part of toxin-antitoxin (TA) operon with
Rv0550c, contains PIN domain (see Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to others e.g.
Rv0960,Rv0065, and Rv1720c from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0549c"
/db_xref="EnsemblGenomes-Tr:CCP43287"
/db_xref="GOA:P9WFB7"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFB7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43287.1"
/translation="MRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHA
PAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQVPVTRHGLSSLLAGAWSRRDTLR
LTDALYVELAETAGLVLLTTDERLARAWPSAHAIG"
gene complement(640638..640904)
/gene="vapB3"
/locus_tag="Rv0550c"
CDS complement(640638..640904)
/codon_start=1
/transl_table=11
/gene="vapB3"
/locus_tag="Rv0550c"
/product="Possible antitoxin VapB3"
/note="Rv0550c, (MTCY25D10.29c), len: 88 aa. Possible
vapB3, antitoxin, part of toxin-antitoxin (TA) operon with
Rv0549c (See Arcus et al., 2005; Pandey and Gerdes,
2005)."
/db_xref="EnsemblGenomes-Gn:Rv0550c"
/db_xref="EnsemblGenomes-Tr:CCP43288"
/db_xref="GOA:P9WJ59"
/db_xref="InterPro:IPR009956"
/db_xref="UniProtKB/Swiss-Prot:P9WJ59"
/protein_id="CCP43288.1"
/translation="MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQ
AAISAELENSATDAWLEGLEPRSTGARHDDVLGAIDAARDEFEA"
gene complement(641096..642811)
/gene="fadD8"
/locus_tag="Rv0551c"
CDS complement(641096..642811)
/codon_start=1
/transl_table=11
/gene="fadD8"
/locus_tag="Rv0551c"
/product="Probable fatty-acid-CoA ligase FadD8
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0551c, (MTCY25D10.30c), len: 571 aa. Probable
fadD8, fatty-acid-CoA synthetase, similar to many e.g.
LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561
aa), FASTA scores: opt: 585, E(): 9.5e-30, (28.7% identity
in 536 aa overlap); etc. Contains PS00455 Putative
AMP-binding domain signature. Note other possible start
sites exist downstream of this start."
/db_xref="EnsemblGenomes-Gn:Rv0551c"
/db_xref="EnsemblGenomes-Tr:CCP43289"
/db_xref="GOA:O06417"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O06417"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43289.1"
/translation="MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELL
RSPTHNGHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVAVG
LLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLIIDPNPMFVER
ALALLEQVDSLQQILTIGPVPDALKHVAVDLSAEAAKYQPQPLVAADLPPDQVIGLTY
TGGTTGKPKGVIGTAQSIATMTSIQLAEWEWPANPRFLMCTPLSHAGAAFFTPTVIKG
GEMIVLAKFDPAEVLRIIEEQRITATMLVPSMLYALLDHPDSHTRDLSSLETVYYGAS
AINPVRLAEAIRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVAL
LDEHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLAREDSDGFYY
IVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKWGEAVTAVVVLRSNA
ARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDSLPLTGLGKPDKKAVRARFWEGA
GRAVG"
repeat_region complement(642754..642811)
/gene="fadD8"
/locus_tag="Rv0551c"
/note="58 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene 642889..644493
/locus_tag="Rv0552"
CDS 642889..644493
/codon_start=1
/transl_table=11
/locus_tag="Rv0552"
/product="Conserved protein"
/note="Rv0552, (MTCY25D10.31), len: 534 aa. Conserved
protein, similar to others from several organisms. Also
shows some similarity with regulatory proteins e.g.
AEPA_ERWCA|Q06555 exoenzymes regulatory protein aepA
[Precursor] from Erwinia carotovora (465 aa), FASTA
scores: opt: 278, E(): 7.6e-11, (23.0% identity in 408 aa
overlap). Also similar to Z99119|BSUB0016_28 from Bacillus
subtilis (529 aa), FASTA scores: opt: 436, E(): 8.3e-20,
(23.8% identity in 547 aa overlap). C-terminus is similar
to MLRRNOPR_1 hypothetical 17.7 kDa protein from
Mycobacterium leprae (154 aa), FASTA score: (43.1%
identity in 160 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0552"
/db_xref="EnsemblGenomes-Tr:CCP43290"
/db_xref="GOA:O06418"
/db_xref="InterPro:IPR011059"
/db_xref="InterPro:IPR013108"
/db_xref="InterPro:IPR032466"
/db_xref="InterPro:IPR033932"
/db_xref="UniProtKB/TrEMBL:O06418"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43290.1"
/translation="MADADLVMTGTVLTVDDARPTAEAIAVADGRVIAVGDRSEVAGL
VGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRDADDVVAAIRGE
VARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLVIIHNSGHKAYFNSHAAWL
NGLTRDTADPKGAKYGRDGNGELDGTAEEIGAILPLLAGVADPSNFGAMLRAECARLN
RAGLTTCSEMAFDPGYRPMVEAVRAELTVRLCTYEISNARMCTDATPGQGDDMLRQVG
IKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCANYTREQLAEIVGAYFPRGW
QIACHVHGDGGVDTILDVYEEALRRNPRDDHRLRLEHVGAIRPDQLRRAAELGVTCSI
FVDQIHYWGDVIVDDLFGAQRGSRWMPAGSAVAAGMRISLHNDPPVTPEEPLRNISVA
ATRVAPSGRVLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLSADP
RTVPPEQIADLAVRATFLAGRQVYRR"
gene 644490..645470
/gene="menC"
/locus_tag="Rv0553"
CDS 644490..645470
/codon_start=1
/transl_table=11
/gene="menC"
/locus_tag="Rv0553"
/product="Probable muconate cycloisomerase MenC
(cis,cis-muconate lactonizing enzyme) (MLE)"
/note="Rv0553, (MTCY25D10.32), len: 326 aa. Probable
menC,muconate cycloisomerase, equivalent to
NP_302476.1|NC_002677 putative isomerase/racemase from
Mycobacterium leprae (334 aa). Also similar to other
muconate cycloisomerases e.g. TCBD_PSESP|P27099
chloromuconate cycloisomerase (370 aa), FASTA scores: opt:
249, E(): 7.8e-09, (32.7% identity in 199 aa overlap).
Also similar to O-succinylbenzoate-CoA synthases. Belongs
to the mandelate racemase / muconate lactonizing enzyme
family."
/db_xref="EnsemblGenomes-Gn:Rv0553"
/db_xref="EnsemblGenomes-Tr:CCP43291"
/db_xref="GOA:P9WJP3"
/db_xref="InterPro:IPR010196"
/db_xref="InterPro:IPR013342"
/db_xref="InterPro:IPR029017"
/db_xref="InterPro:IPR029065"
/db_xref="InterPro:IPR036849"
/db_xref="InterPro:IPR041338"
/db_xref="UniProtKB/Swiss-Prot:P9WJP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43291.1"
/translation="MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWG
EFGAFVEYQSAQACAWLASAIETAYCAPPPVRRDRVPINATVPAVAAAQVGEVLARFP
GARTAKVKVAEPGQSLADDIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGP
LEYLEQPCATVAELAELRRRVDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGG
ISALLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAE
PAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVPSFG"
gene 645467..646255
/gene="bpoC"
/locus_tag="Rv0554"
CDS 645467..646255
/codon_start=1
/transl_table=11
/gene="bpoC"
/locus_tag="Rv0554"
/product="Possible peroxidase BpoC (non-haem peroxidase)"
/note="Rv0554, (MTCY25D10.33), len: 262 aa. Possible
bpoC,peroxidase (non-haem peroxidase), equivalent to
NP_302477.1|NC_002677 putative hydrolase from
Mycobacterium leprae (265 aa). Also highly similar or
similar to various hydrolases and peroxidases e.g.
CAB38877.1|AL035707|T36181 probable hydrolase from
Streptomyces coelicolor (272 aa); CAC48368.1|Y16952
putative hydrolase from Amycolatopsis mediterranei (284
aa); P29715|BPA2_STRAU non-haem bromoperoxidase bpo-a2
(bromide peroxidase) from Streptomyces aureofaciens (277
aa), FASTA scores: opt: 325,E(): 2.3e-15, (29.5% identity
in 268 aa overlap); O31168|PRXC_STRAU|CPO|CPOT non-heme
chloroperoxidase (chloride peroxidase) from Streptomyces
aureofaciens (278 aa); etc. Also similar to M.
tuberculosis non-heme haloperoxidases and epoxide
hydrolases e.g. Rv1938, Rv3617,etc."
/db_xref="EnsemblGenomes-Gn:Rv0554"
/db_xref="EnsemblGenomes-Tr:CCP43292"
/db_xref="GOA:P9WNH1"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:3E3A"
/db_xref="PDB:3HSS"
/db_xref="PDB:3HYS"
/db_xref="PDB:3HZO"
/db_xref="UniProtKB/Swiss-Prot:P9WNH1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43292.1"
/translation="MINLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCI
TFDNRGIGATENAEGFTTQTMVADTAALIETLDIAPARVVGVSMGAFIAQELMVVAPE
LVSSAVLMATRGRLDRARQFFNKAEAELYDSGVQLPPTYDARARLLENFSRKTLNDDV
AVGDWIAMFSMWPIKSTPGLRCQLDCAPQTNRLPAYRNIAAPVLVIGFADDVVTPPYL
GREVADALPNGRYLQIPDAGHLGFFERPEAVNTAMLKFFASVKA"
gene 646298..647962
/gene="menD"
/locus_tag="Rv0555"
CDS 646298..647962
/codon_start=1
/transl_table=11
/gene="menD"
/locus_tag="Rv0555"
/product="Probable bifunctional menaquinone biosynthesis
protein MenD : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-
carboxylate synthase (SHCHC synthase) + 2-oxoglutarate
decarboxylase (alpha-ketoglutarate decarboxylase) (KDC)"
/note="Rv0555, (MTCY25D10.34), len: 554 aa. Probable
menD,menaquinone biosynthesis protein, including
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate
synthase and 2-oxoglutarate decarboxylase activities.
Equivalent to NP_302478.1|NC_002677 putative
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate
synthase / 2-oxoglutarate decarboxylase from Mycobacterium
leprae (556 aa). Also similar to others e.g.
MEND_BACSU|P23970 2-succinyl-6-hydroxy-2,4-cyclohexadiene-
1-carboxylate synthase from Bacillus subtilis (548 aa),
FASTA scores: opt: 488, E(): 2.3e-21, (34.3% identity in
545 aa overlap); etc. Cofactor: thiamine pyrophosphate."
/db_xref="EnsemblGenomes-Gn:Rv0555"
/db_xref="EnsemblGenomes-Tr:CCP43293"
/db_xref="GOA:P9WK11"
/db_xref="InterPro:IPR004433"
/db_xref="InterPro:IPR012001"
/db_xref="InterPro:IPR029061"
/db_xref="PDB:5ERX"
/db_xref="PDB:5ERY"
/db_xref="PDB:5ESD"
/db_xref="PDB:5ESO"
/db_xref="PDB:5ESS"
/db_xref="PDB:5ESU"
/db_xref="UniProtKB/Swiss-Prot:P9WK11"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43293.1"
/translation="MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRS
GRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIV
LSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRV
LAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPL
DIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLG
RPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAA
MNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRG
IRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGL
LIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAY
HVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL"
gene 647959..648474
/locus_tag="Rv0556"
CDS 647959..648474
/codon_start=1
/transl_table=11
/locus_tag="Rv0556"
/product="Probable conserved transmembrane protein"
/note="Rv0556, (MTCY25D10.35), len: 171 aa. Probable
conserved transmembrane protein, equivalent to
NP_302479.1|NC_002677 putative membrane protein from
Mycobacterium leprae (175 aa). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0556"
/db_xref="EnsemblGenomes-Tr:CCP43294"
/db_xref="GOA:O06422"
/db_xref="UniProtKB/TrEMBL:O06422"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43294.1"
/translation="MISPKPLLHILIHGLSDELPDTRGRIVLRWLRIAVLIVTGLVTL
QSVLLVAGAWRNDIAIQRNMGVAQAEVLSAGPRRSTIEFVTPDRITYRPQLGVLYPSE
LSTGMRIYVEYNKRDPNLVRVQHRNAGLAIIPAGSIAVVAWLIAAAALVVLAVLDKRL
ERRENSASATG"
gene 648536..649672
/gene="mgtA"
/gene_synonym="mtfB"
/locus_tag="Rv0557"
CDS 648536..649672
/codon_start=1
/transl_table=11
/gene="mgtA"
/gene_synonym="mtfB"
/locus_tag="Rv0557"
/product="Mannosyltransferase MgtA"
/note="Rv0557, (MTCY25D10.36), len: 378 aa. MgtA
(previously known as pimB), mannosyltransferase (see
citation below), similar to other various transferases
e.g. NP_243554.1|NC_002570
alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol
monomannoside transferase from Bacillus halodurans (381
aa); NP_249533.1|NC_002516 probable glycosyl transferase
from Pseudomonas aeruginosa (406 aa);
NP_419573.1|NC_002696 glycosyl transferase, group 1 family
protein, from Caulobacter crescentus (455 aa); etc. Also
similar to Q55598 hypothetical 44.9 kDa protein from
synechocystis SP (409 aa), FASTA scores: opt: 703, E(): 0,
(33.9% identity in 378 aa overlap); GPI3_YEAST|P32363
n-acetylglucosaminyl-phosphatidylinositol biosynthetic
protein (452 aa), FASTA scores: opt: 230, E():
1.1e-07,(23.5% identity in 328 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0557"
/db_xref="EnsemblGenomes-Tr:CCP43295"
/db_xref="GOA:P9WMY5"
/db_xref="InterPro:IPR001296"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/Swiss-Prot:P9WMY5"
/protein_id="CCP43295.1"
/translation="MCGVRVAIVAESFLPQVNGVSNSVVKVLEHLRRTGHEALVIAPD
TPPGEDRAERLHDGVRVHRVPSRMFPKVTTLPLGVPTFRMLRALRGFDPDVVHLASPA
LLGYGGLHAARRLGVPTVAVYQTDVPGFASSYGIPMTARAAWAWFRHLHRLADRTLAP
STATMESLIAQGIPRVHRWARGVDVQRFAPSARNEVLRRRWSPDGKPIVGFVGRLAPE
KHVDRLTGLAASGAVRLVIVGDGIDRARLQSAMPTAVFTGARYGKELAEAYASMDVFV
HSGEHETFCQVVQEALASGLPVIAPDAGGPRDLITPHRTGLLLPVGEFEHRLPDAVAH
LVHERQRYALAARRSVLGRSWPVVCDELLGHYEAVRGRRTTQAA"
gene 649689..650393
/gene="menH"
/gene_synonym="menG"
/gene_synonym="ubiE"
/locus_tag="Rv0558"
CDS 649689..650393
/codon_start=1
/transl_table=11
/gene="menH"
/gene_synonym="menG"
/gene_synonym="ubiE"
/locus_tag="Rv0558"
/product="Probable ubiquinone/menaquinone biosynthesis
methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone
methyltransferase)"
/note="Rv0558, (MTCY25D10.37), len: 234 aa. Probable menH
(alternate gene name: menG), ubiquinone/menaquinone
biosynthesis methlytransferase
(2-heptaprenyl-1,4-naphthoquinone
methyltransferase),equivalent to NP_302480.1|NC_002677
putative ubiquinone/menaquinone biosynthesis
methyltransferase from Mycobacterium leprae (238 aa). Also
highly similar to others e.g. CAB44537.1|AL078618|T34630
from Streptomyces coelicolor (231 aa); UBIE_ECOLI|P27851
from Escherichia coli strain K12 (251 aa), FASTA scores:
opt: 421, E(): 1.2e-21, (43.2% identity in 227 aa
overlap); GRC2_BACSU|P31113 from Bacillus subtilis (233
aa), FASTA scores: opt: 345, E(): 1.4e-16, (34.6% identity
in 231 aa overlap); etc. Belongs to the UbiE family. Note
that previously known as ubiE."
/db_xref="EnsemblGenomes-Gn:Rv0558"
/db_xref="EnsemblGenomes-Tr:CCP43296"
/db_xref="GOA:P9WFR3"
/db_xref="InterPro:IPR004033"
/db_xref="InterPro:IPR023576"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFR3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43296.1"
/translation="MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRATR
SALRIGPGQKVLDLAAGTAVSTVELTKSGAWCVAADFSVGMLAAGAARKVPKVAGDAT
RLPFGDDVFDAVTISFGLRNVANQQAALREMARVTRPGGRLLVCEFSTPTNALFATAY
KEYLMRALPRVARAVSSNPEAYEYLAESIRAWPDQAVLAHQISRAGWSGVRWRNLTGG
IVALHAGYKPGKQTPQ"
gene complement(650407..650745)
/locus_tag="Rv0559c"
CDS complement(650407..650745)
/codon_start=1
/transl_table=11
/locus_tag="Rv0559c"
/product="Possible conserved secreted protein"
/note="Rv0559c, (MTCY25D10.38c), len: 112 aa. Possible
conserved secreted protein, similar to
NP_302481.1|NC_002677 putative secreted protein from
Mycobacterium leprae (112 aa). Also similar to
Y08B_MYCTU|Q11048 hypothetical 11.6 kDa protein FASTA
scores: opt: 111, E(): 011, (25.4% identity in 114 aa
overlap). Contains possible N-terminal signal sequence. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0559c"
/db_xref="EnsemblGenomes-Tr:CCP43297"
/db_xref="GOA:P9WKL3"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/Swiss-Prot:P9WKL3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43297.1"
/translation="MKGTKLAVVVGMTVAAVSLAAPAQADDYDAPFNNTIHRFGIYGP
QDYNAWLAKISCERLSRGVDGDAYKSATFLQRNLPRGTTQGQAFQFLGAAIDHYCPEH
VGVLQRAGTR"
gene complement(650779..651504)
/locus_tag="Rv0560c"
CDS complement(650779..651504)
/codon_start=1
/transl_table=11
/locus_tag="Rv0560c"
/product="Possible benzoquinone methyltransferase
(methylase)"
/note="Rv0560c, (MTCY25D10.39c), len: 241 aa. Possible
benzoquinone methyltransferase (see citation
below),similar to other hypothetical proteins and
methyltransferases e.g. Q54300 methyltransferase (211
aa),FASTA scores: opt: 203, E(): 4.8e-07, (30.9% identity
in 136 aa overlap). Similar to Rv3699, Rv1377c, Rv2675c,
etc from Mycobacterium tuberculosis. Rv0560c can be
induced by salicylate and para-amino-salicylate (pas)."
/db_xref="EnsemblGenomes-Gn:Rv0560c"
/db_xref="EnsemblGenomes-Tr:CCP43298"
/db_xref="GOA:P9WKL5"
/db_xref="InterPro:IPR025714"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WKL5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43298.1"
/translation="MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPW
SIGEPQPELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELARH
EAAKRGLANASFEVADASSFTGYDGRFDTIVDSTLFHSMPVESREGYLQSIVRAAAPG
ASYFVLVFDRAAIPEGPINAVTEDELRAAVSKYWIIDEIKPARLYARFPAGFAGMPAL
LDIREEPNGLQSIGGWLLSAHLG"
gene complement(651529..652755)
/locus_tag="Rv0561c"
CDS complement(651529..652755)
/codon_start=1
/transl_table=11
/locus_tag="Rv0561c"
/product="Possible oxidoreductase"
/note="Rv0561c, (MTCY25D10.40c), len: 408 aa. Possible
oxidoreductase, highly similar (except in first 30 aa) to
NP_302482.1|NC_002677 putative FAD-linked oxidoreductase
from Mycobacterium leprae (408 aa). Also similar to T34627
probable electron transfer oxidoreductase from
Streptomyces coelicolor (430 aa); and some
bacteriochlorophyll synthases e.g. NP_069300.1|NC_000917
bacteriochlorophyll synthase from Archaeoglobus fulgidus
(410 aa); Q55087 geranylgeranyl hydrogenase (407 aa),
FASTA scores: opt: 208, E(): 1.7e-06,(26.9% identity in
327 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0561c"
/db_xref="EnsemblGenomes-Tr:CCP43299"
/db_xref="GOA:P9WNY9"
/db_xref="InterPro:IPR002938"
/db_xref="InterPro:IPR011777"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WNY9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43299.1"
/translation="MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRDK
PCGDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWPGPSFPSYGSAVA
RLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVSLTLADGTEVGCRQLIVADGA
RSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYGWIFP
LGNGEVNIGVGALSTSRRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGGA
VSGVAGSNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRY
GRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLVTDDDRDWVARVWR
GGGQLSRLVDRRPPFS"
gene 652771..653778
/gene="grcC1"
/locus_tag="Rv0562"
CDS 652771..653778
/codon_start=1
/transl_table=11
/gene="grcC1"
/locus_tag="Rv0562"
/product="Probable polyprenyl-diphosphate synthase GrcC1
(polyprenyl pyrophosphate synthetase)"
/note="Rv0562, (MTCY25D10.41), len: 335 aa. Probable
grcC1,polyprenyl diphosphate synthetase, equivalent to
NP_302483.1|NC_002677 polyprenyl diphosphate synthase
component from Mycobacterium leprae (330 aa). Also similar
to others (generally hepta or hexaprenyl) e.g.
GRC3_BACSU|P31114 probable heptaprenyl diphosphate
syntetase (348 aa), FASTA scores: opt: 599, E():
4e-31,(33.2% identity in 307 aa overlap); etc. Also highly
similar to Mycobacterium tuberculosis proteins
Rv0989c|grcC2|NP_215504.1|MTCI237.03c probable
polyprenyl-diphosphate synthase (325 aa); Rv3383c,
Rv3398c,etc. Contains PS00444 Polyprenyl synthetases
signature 2. Belongs to the FPP/GGPP synthetases family."
/db_xref="EnsemblGenomes-Gn:Rv0562"
/db_xref="EnsemblGenomes-Tr:CCP43300"
/db_xref="GOA:O06428"
/db_xref="InterPro:IPR000092"
/db_xref="InterPro:IPR008949"
/db_xref="InterPro:IPR033749"
/db_xref="UniProtKB/TrEMBL:O06428"
/inference="protein motif:PROSITE:PS00444"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43300.1"
/translation="MRTPATVVAGVDLGDAVFAAAVRAGVARVEQLMDTELRQADEVM
SDSLLHLFNAGGKRFRPLFTVLSAQIGPQPDAAAVTVAGAVIEMIHLATLYHDDVMDE
AQVRRGAPSANAQWGNNVAILAGDYLLATASRLVARLGPEAVRIIADTFAQLVTGQMR
ETRGTSENVDSIEQYLKVVQEKTGSLIGAAGRLGGMFSGATDEQVERLSRLGGVVGTA
FQIADDIIDIDSESDESGKLPGTDVREGVHTLPMLYALRESGPDCARLRALLNGPVDD
DAEVREALTLLRASPGMARAKDVLAQYAAQARHELALLPDVPGRRALAALVDYTVSRH
G"
gene 653879..654739
/gene="htpX"
/locus_tag="Rv0563"
CDS 653879..654739
/codon_start=1
/transl_table=11
/gene="htpX"
/locus_tag="Rv0563"
/product="Probable protease transmembrane protein heat
shock protein HtpX"
/note="Rv0563, (MTV039.01, MTCY25D10.42), len: 286 aa.
(alternative start at position 654006). Probable
htpX,protease heat shock protein X (transmembrane
protein),equivalent to NP_302484.1|NC_002677 putative
peptidase from Mycobacterium leprae (287 aa). Also highly
similar to others e.g. CAC08262.1|AL392146 putative
peptidase from Streptomyces coelicolor (287 aa);
NP_387431.1|NC_003047 putative protease transmembrane
protein from Sinorhizobium meliloti (319 aa);
NP_105051.1|NC_002678 heat shock protein (htpX) from
Mesorhizobium loti (336 aa);
NP_248692.1|NC_000909|U67608|MJU67608_8 heat shock protein
HtpX, possibly protease (htpX) from Methanococcus
jannaschii (284 aa), FASTA scores: opt: 660, E(): 0, (46.5
identity in 245 aa overlap). Continuation of MTCY25D10.42.
Belongs to peptidase family M48 (zinc metalloprotease).
Cofactor: Zinc. Conserved in M. tuberculosis, M. leprae,
M. bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0563"
/db_xref="EnsemblGenomes-Tr:CCP43301"
/db_xref="GOA:P9WHS5"
/db_xref="InterPro:IPR001915"
/db_xref="InterPro:IPR022919"
/db_xref="UniProtKB/Swiss-Prot:P9WHS5"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43301.1"
/translation="MTWHPHANRLKTFLLLVGMSALIVAVGALFGRTALMLAALFAVG
MNVYVYFNSDKLALRAMHAQPVSELQAPAMYRIVRELATSAHQPMPRLYISDTAAPNA
FATGRNPRNAAVCCTTGILRILNERELRAVLGHELSHVYNRDILISCVAGALAAVITA
LANMAMWAGMFGGNRDNANPFALLLVALLGPIAATVIRMAVSRSREYQADESGAVLTG
DPLALASALRKISGGVQAAPLPPEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDR
IRRLEAMARG"
gene complement(654924..655949)
/gene="gpdA1"
/gene_synonym="glyC"
/gene_synonym="gpsA"
/locus_tag="Rv0564c"
CDS complement(654924..655949)
/codon_start=1
/transl_table=11
/gene="gpdA1"
/gene_synonym="glyC"
/gene_synonym="gpsA"
/locus_tag="Rv0564c"
/product="Probable glycerol-3-phosphate dehydrogenase
[NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate
dehydrogenase) (NAD(P)H-dependent
dihydroxyacetone-phosphate reductase)"
/note="Rv0564c, (MTV039.02c), len: 341 aa. Possible
gpdA1(alternate gene names: gpsA,
glyC),glycerol-3-phosphate dehydrogenase [NAD(P)+]
dependent,similar to many other glycerol-3-phosphate
dehydrogenases e.g. P46919|GPDA_BACSU from Bacillus
subtilis (345 aa),FASTA scores: opt: 731, E(): 0, (37.3%
identity in 332 aa overlap); etc. Also similar to
Rv2982c|gpdA2|MTCY349.05|Z83018|MTCY349_5 from
Mycobacterium tuberculosis (334 aa), FASTA scores: opt:
740, E(): 0, (40.4% identity in 322 aa overlap). Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the NAD-dependent glycerol-3-phosphate dehydrogenase
family."
/db_xref="EnsemblGenomes-Gn:Rv0564c"
/db_xref="EnsemblGenomes-Tr:CCP43302"
/db_xref="GOA:P9WN75"
/db_xref="InterPro:IPR006109"
/db_xref="InterPro:IPR006168"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR011128"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN75"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43302.1"
/translation="MAANKREPKVVVLGGGSWGTTVASICARRGPTLQWVRSAVTAQD
INDNHRNSRYLGNDVVLSDTLRATTDFTEAANCADVVVMGVPSHGFRGVLVELSKELR
PWVPVVSLVKGLEQGTNMRMSQIIEEVLPGHPAGILAGPNIAREVAEGYAAAAVLAMP
DQHLATRLSAMFRTRRFRVYTTDDVVGVETAGALKNVFAIAVGMGYSLGIGENTRALV
IARALREMTKLGVAMGGKSETFPGLAGLGDLIVTCTSQRSRNRHVGEQLGAGKPIDEI
IASMSQVAEGVKAAGVVMEFANEFGLNMPIAREVDAVINHGSTVEQAYRGLIAEVPGH
EVHGSGF"
gene complement(656010..657470)
/locus_tag="Rv0565c"
CDS complement(656010..657470)
/codon_start=1
/transl_table=11
/locus_tag="Rv0565c"
/product="Probable monooxygenase"
/note="Rv0565c, (MTV039.03c), len: 486 aa. Probable
monoxygenase, highly similar to NP_301173.1|NC_002677
putative monooxygenase from Mycobacterium leprae (494 aa).
Also highly similar to others e.g. NP_421371.1|NC_002696
monooxygenase (flavin-binding family) from Caulobacter
crescentus (498 aa); C-terminus of NP_051574.1|NC_000958
arylesterase/monoxygenase from Deinococcus radiodurans
(833 aa); P12015|CYMO_ACISP cyclohexanone monooxygenase
from Acinetobacter sp. (542 aa), FASTA scores: opt: 354,
E(): 2.1e-16, (23.7% identity in 435 aa overlap); etc.
Also similar to other putative monoxygenases from
Mycobacterium tuberculosis e.g. Rv3854c (489 aa),
MTCY01A6.14 (489 aa),MTV013_4 (495 aa), MTCY31.20 (495
aa)."
/db_xref="EnsemblGenomes-Gn:Rv0565c"
/db_xref="EnsemblGenomes-Tr:CCP43303"
/db_xref="GOA:O53762"
/db_xref="InterPro:IPR020946"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O53762"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43303.1"
/translation="MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRA
RIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGIADGAHIREYLTDMAHKYGIDRH
IEFNSYVRAADWDSSTDTWTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIE
KFGGAVVHPQHWPEDLDYTGKKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLIS
ASKYSTFAAVVRKALPPKTSHLIVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNL
PEGYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHIDHFDATGIALKSG
GHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTN
ASWTLRADMTARATAKLLAHMAAHGHTRAAPHLGDEPMDEKPSWDIQAGYVKRAPYAL
PKSGTKRPWNVRQNYLADAIDYRFDRIEEAMVFGAA"
gene complement(657548..658039)
/locus_tag="Rv0566c"
CDS complement(657548..658039)
/codon_start=1
/transl_table=11
/locus_tag="Rv0566c"
/product="Conserved protein"
/note="Rv0566c, (MTV039.04c), len: 163 aa. Conserved
protein, similar to others e.g. P77482|YAJQ_ECOLI
hypothetical 19.0 KDa protein from Escherichia coli (169
aa), FASTA scores: opt: 422, E(): 5.4e-20, (44.1 identity
in 161 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0566c"
/db_xref="EnsemblGenomes-Tr:CCP43304"
/db_xref="GOA:P9WFK9"
/db_xref="InterPro:IPR007551"
/db_xref="InterPro:IPR035570"
/db_xref="InterPro:IPR035571"
/db_xref="InterPro:IPR036183"
/db_xref="UniProtKB/Swiss-Prot:P9WFK9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43304.1"
/translation="MADSSFDIVSKVDRQEVDNALNQAAKELATRFDFRGTDTKIAWK
GDEAVELTSSTEERVKAAVDVFKEKLIRRDISLKAFEAGEPQASGKTYKVTGALKQGI
SSENAKKITKLIRDAGPKNVKTQIQGDEVRVTSKKRDDLQAVIAMLKKADLDVALQFV
NYR"
gene 658109..658189
/gene="tyrT"
tRNA 658109..658189
/gene="tyrT"
/product="tRNA-Tyr"
/anticodon=(pos:658143..658145,aa:Tyr,seq:gta)
/note="codon recognized: UAC; tyrT, tRNA-Tyr, anticodon
gta, length = 81"
gene 658321..659340
/locus_tag="Rv0567"
CDS 658321..659340
/codon_start=1
/transl_table=11
/locus_tag="Rv0567"
/product="Probable methyltransferase/methylase"
/note="Rv0567, (MTV039.05), len: 339 aa. Probable
methyltransferase, similar to several e.g.
P39896|TCMO_STRGA tetracenomycin polyketide synthesis
8-O-methyltransferase from Streptomyces glaucescens (339
aa), FASTA scores: opt: 685, E(): 0, (35.8% identity in
335 aa overlap); P10950|HIOM_BOVIN hydroxyindole
O-methyltransferase from Bos taurus (345 aa), FASTA
scores: opt: 509, E(): 3.4e-27, (30.7% identity in 332 aa
overlap) etc."
/db_xref="EnsemblGenomes-Gn:Rv0567"
/db_xref="EnsemblGenomes-Tr:CCP43305"
/db_xref="GOA:O53764"
/db_xref="InterPro:IPR001077"
/db_xref="InterPro:IPR016461"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR031725"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O53764"
/protein_id="CCP43305.1"
/translation="MELSPDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEAIA
DRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEARPTYAGGLLKI
WNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADPRRLEAFMAAMDAASRRNI
ELLAKRFPFERYRRLCDVGCADGLLSRIVAAAHPHLQCVSFDLPAVTEIARRKLTAEG
LGERVQACAGDFLADPLPAADVITMGQILHDWNLDRKQQLVAKAYEALSKEGAFIVIE
TLIDDARRENTTGLMMSLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSA
AVAYK"
gene 659450..660868
/gene="cyp135B1"
/locus_tag="Rv0568"
CDS 659450..660868
/codon_start=1
/transl_table=11
/gene="cyp135B1"
/locus_tag="Rv0568"
/product="Possible cytochrome P450 135B1 Cyp135B1"
/note="Rv0568, (MT0594, MTV039.06), len: 472 aa. Possible
cyp135B1, cytochrome P450, similar to putative cytochrome
P-450 monoxygenases and other cytochrome P-450 related
enzymes e.g. P29980|CPXN_ANASP probable cytochrome P450
from Anabaena sp. strain PCC 7120 (459 aa), FASTA scores:
opt: 525, E(): 7.2e-27, (31.9% identity in 417 aa
overlap); etc. Also similar to others from Mycobacterium
tuberculosis e.g. Rv0327c|NP_214841.1|NC_000962|CYP135A1|M
T0342|MTCY63.32c putative cytochrome P450 (449 aa), FASTA
scores: opt: 1080,E(): 0, (40.5% identity in 444 aa
overlap); Rv3685c|NP_218202.1|NC_000962 putative
cytochrome P450 (476 aa); Rv0136|NP_214650.1|NC_000962
putative cytochrome P450 (441 aa); etc. Contains
cytochrome P450 cysteine heme-iron ligand signature
(PS00086)."
/db_xref="EnsemblGenomes-Gn:Rv0568"
/db_xref="EnsemblGenomes-Tr:CCP43306"
/db_xref="GOA:P9WPM9"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002401"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPM9"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43306.1"
/translation="MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFT
LHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLAGLLGDSSLLLIDDDVHRDR
RRLMSPPFHRDAVARQAGPIAEIAAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGA
SDPVRLAALRKVMPRLLNVGPWATLALANPSLLNNRLWSRLRRRIEEADALLYAEIAD
RRADPDLAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWALER
LTRHPVTLAKAVQAADASAAGDPAGDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAG
YRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGATLSPTTWLPFGGGNRRCLGAT
FAMVEMRVVLREILRRVELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATSQA
TAQGAGCPAARGGGPSRAVGSQ"
gene 661003..661269
/locus_tag="Rv0569"
CDS 661003..661269
/codon_start=1
/transl_table=11
/locus_tag="Rv0569"
/product="Conserved protein"
/note="Rv0569, (MTV039.07), len: 88 aa. Conserved protein.
C-terminus highly similar to AAA63065.1|U15184|MLU15184_10
hypothetical protein from Mycobacterium leprae (53
aa),FASTA scores: opt: 140, E(): 0.0046, (64.7% identity
in 34 aa overlap). Also similar to T36824|SCI35.11
hypothetical protein from Streptomyces coelicolor (64 aa);
and N-terminus of T36956 probable DNA-binding protein from
Streptomyces coelicolor (323 aa). Also highly similar to
Rv2302|MTCY339.07c|NP_216818.1|NC_000962 conserved
hypothetical protein from Mycobacterium tuberculosis (80
aa), FASTA scores: opt: 300, E(): 1.4e-13, (61.8% identity
in 76 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0569"
/db_xref="EnsemblGenomes-Tr:CCP43307"
/db_xref="GOA:P9WM83"
/db_xref="InterPro:IPR015035"
/db_xref="UniProtKB/Swiss-Prot:P9WM83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43307.1"
/translation="MKAKVGDWLVIKGATIDQPDHRGLIIEVRSSDGSPPYVVRWLET
DHVATVIPGPDAVVVTAEEQNAADERAQHRFGAVQSAILHARGT"
gene 661295..663373
/gene="nrdZ"
/locus_tag="Rv0570"
CDS 661295..663373
/codon_start=1
/transl_table=11
/gene="nrdZ"
/locus_tag="Rv0570"
/product="Probable ribonucleoside-diphosphate reductase
(large subunit) NrdZ (ribonucleotide reductase)"
/note="Rv0570, (MTV039.08), len: 692 aa. Probable
nrdZ,ribonucleoside-diphosphate reductase, large subunit,
highly similar to others e.g.
NP_070492.1|NC_000917|NRD|AE000988_11 ribonucleotide
reductase from Archaeoglobus fulgidus (752 aa), FASTA
scores: opt: 2001, E(): 0, (52.5% identity in 562 aa
overlap) (N-terminus shorter); U73619|TAU73619_1|T37459
ribonucleotide reductase from Thermoplasma acidophilum
(857 aa), FASTA scores: opt: 1678, E(): 0, (43.7% identity
in 723 aa overlap); etc. Belongs to the ribonucleoside
diphosphate reductase large chain family."
/db_xref="EnsemblGenomes-Gn:Rv0570"
/db_xref="EnsemblGenomes-Tr:CCP43308"
/db_xref="GOA:P9WH77"
/db_xref="InterPro:IPR000788"
/db_xref="InterPro:IPR005144"
/db_xref="InterPro:IPR008926"
/db_xref="InterPro:IPR013344"
/db_xref="InterPro:IPR013509"
/db_xref="UniProtKB/Swiss-Prot:P9WH77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43308.1"
/translation="MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPG
TVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLG
VRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRW
AERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRA
GGGTGYAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDV
SHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPA
AELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGS
INLARMLADGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMG
LAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG
PRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDRLARDRG
FYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSK
TVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTEFS
GGCAGRSCEF"
gene complement(663487..664818)
/locus_tag="Rv0571c"
CDS complement(663487..664818)
/codon_start=1
/transl_table=11
/locus_tag="Rv0571c"
/product="Conserved protein"
/note="Rv0571c, (MTV039.09c), len: 443 aa. Conserved
protein, highly similar to the products of two adjacent
orfs in Mycobacterium leprae:
AAA63059.1|U15184|U650S|Q50111 hypothetical protein (258
aa), FASTA scores: opt: 1071, E(): 0, (72.5% identity in
233 aa overlap); and AAA63058.1|U15184|U650T hypothetical
protein (86 aa), FASTA scores: opt: 192, E():
6.4e-06,(70.8% identity in 48 aa overlap). Also similar to
others e.g. NP_107072.1|NC_002678 hypothetical protein
from Mesorhizobium loti (235 aa); NP_213031.1|NC_000918
hypothetical protein from Aquifex aeolicus (175 aa); etc.
And similar to part of hypothetical proteins from
Mycobacterium tuberculosis e.g. C-terminus of
Rv2143|MTCY270.25c|Z95388|NP_216659.1|NC_000962 (352
aa),FASTA scores: opt: 592, E(): 7e-32, (49.3% identity in
205 aa overlap); N-terminus of
Rv2030c|NP_216546.1|NC_000962 (681 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0571c"
/db_xref="EnsemblGenomes-Tr:CCP43309"
/db_xref="GOA:P9WHK1"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR002925"
/db_xref="InterPro:IPR029057"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WHK1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43309.1"
/translation="MKLFDDRGDAGRQLAQRLAQLSGKAVVVLGLPRGGVPVAFEVAK
SLQAPLDVLVVRKLGVPFQPELAFGAIGEDGVRVLNDDVVRGTHLDAAAMDAVERKQL
IELQRRAERFRRGRDRIPLTGRIAVIVDDGIATGATAKAACQVARAHGADKVVLAVPI
GPDDIVARFAGYADEVVCLATPALFFAVGQGYRNFTQTSDDEVVAFLDRAHRDFAEAG
AIDAAADPPLRDEEVQVVAGPVPVAGHLTVPEKPRGIVVFAHGSGSSRHSIRNRYVAE
VLTGAGFATLLFDLLTPEEERNRANVFDIELLASRLIDVTGWLATQPDTASLPVGYFG
ASTGAGAALVAAADPRVNVRAVVSRGGRPDLAGDSLGSVVAPTLLIVGGRDQVVLELN
QRAQAVIPGKCQLTVVPGATHLFEEPGTLEQVAKLACDWFIDHLCGPGPSG"
gene complement(665042..665383)
/locus_tag="Rv0572c"
CDS complement(665042..665383)
/codon_start=1
/transl_table=11
/locus_tag="Rv0572c"
/product="Hypothetical protein"
/note="Rv0572c, (MTV039.10c), len: 113 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0572c"
/db_xref="EnsemblGenomes-Tr:CCP43310"
/db_xref="UniProtKB/Swiss-Prot:P9WM81"
/protein_id="CCP43310.1"
/translation="MGEHAIKRHMRQRKPTKHPLAQKRGARILVFTDDPRRSVLIVPG
CHLDSMRREKNAYYFQDGNALVGMVVSGGTVEYDADDRTYVVQLTDGRHTTESSFEHS
SPSRSPQSDDL"
gene complement(665851..667242)
/gene="pncB2"
/locus_tag="Rv0573c"
CDS complement(665851..667242)
/codon_start=1
/transl_table=11
/gene="pncB2"
/locus_tag="Rv0573c"
/product="Nicotinic acid phosphoribosyltransferase PncB2"
/note="Rv0573c, (MTV039.11c), len: 463 aa. PncB2,
nicotinic acid phosphoribosyltransferase (See Boshoff et
al., 2008). Similar to e.g. NP_213718.1|NC_000918
hypothetical protein from Aquifex aeolicus (426 aa);
AL109962|T36953|SCJ1.20 conserved hypothetical protein
from Streptomyces coelicolor (438 aa), FASTA scores: opt:
1089, E(): 0, (49.4% identity in 385 aa overlap);
P_391053.1|Z99120|BSUB0017_57|NC_000964 protein similar to
nicotinate phosphoribosyltransferase from Bacillus
subtilis (490 aa), FASTA scores: opt: 955,E():0, (43.5%
identity in 356 aa overlap); etc. Also similar to
Q10641|Y03F_MYCTU|MTCY130.15c|Rv1330c conserved
hypothetical protein from Mycobacterium tuberculosis (509
aa), FASTA scores: opt: 761, E(): 0, (38.4% identity in
437 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0573c"
/db_xref="EnsemblGenomes-Tr:CCP43311"
/db_xref="GOA:P9WJI7"
/db_xref="InterPro:IPR006405"
/db_xref="InterPro:IPR007229"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR036068"
/db_xref="InterPro:IPR040727"
/db_xref="InterPro:IPR041525"
/db_xref="UniProtKB/Swiss-Prot:P9WJI7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43311.1"
/translation="MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPG
RSYIMAAGLADVVEFLEAFRFDEQDLRYLRGLGQFSDEFLRWLAGVRFTGDVWAAPEG
TVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGAR
RAHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAF
ARLYPATMLLVDTYDTLRGVDHVIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLD
TAGLEQVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYD
GSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGENLPGDPLLVPIMTNGRRIR
QHAPTLDGARDWARQQIDALPPELRSLEDTGYSYPVAVSDRIVGELARLRHADTAEAH
PGSNVVGAKAKRP"
gene complement(667252..668394)
/locus_tag="Rv0574c"
CDS complement(667252..668394)
/codon_start=1
/transl_table=11
/locus_tag="Rv0574c"
/product="Conserved hypothetical protein"
/note="Rv0574c, (MTV039.12c), len: 380 aa. Conserved
hypothetical protein, showing similarity with other
hypothetical proteins and polyglutamate synthases
(encapsulation proteins) e.g.
AAK64444.1|AF377339_5|AF377339 polyglutamate synthase CapA
from Myxococcus xanthus (405 aa); M24150|BACCAPABC_3|CapA
polyglutamate synthase (encapsulation protein) from
B.anthracis (411 aa), FASTA scores: opt: 261, E():
4.3e-10,(25.8% identity in 287 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0574c"
/db_xref="EnsemblGenomes-Tr:CCP43312"
/db_xref="InterPro:IPR019079"
/db_xref="UniProtKB/Swiss-Prot:P9WM79"
/protein_id="CCP43312.1"
/translation="MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATG
YVRLAERVNGRIPLPVDWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVC
YRMHPDNVPALTALRPHVCALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAA
RRSALVTVGHERRVIVGSVAAESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQV
LADKRPGDIAIVSMHWGSNWGYATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYR
GKPILYGCGDVVDDYEGIGGHESFRSELRLLYLTVTDPASGNLISLQMLPLRVSRMRL
QRASQTDTEWLRNTIERISRRFGIRVVTRPDNLLEVVPAANLTSKE"
gene complement(668579..669745)
/locus_tag="Rv0575c"
CDS complement(668579..669745)
/codon_start=1
/transl_table=11
/locus_tag="Rv0575c"
/product="Possible oxidoreductase"
/note="Rv0575c, (MTV039.13c), len: 388 aa. Possible
oxidoreductase, similar to many diverse oxidoreductases
and monooxygenases e.g. AL109974|SCF34_5|T36404 probable
monooxygenase from Streptomyces coelicolor (407 aa), FASTA
scores: opt: 786, E(): 0, (38.7% identity in 398 aa
overlap); P96555|AB000564 salicylate hydroxylase from
sphingomonas (395 aa), FASTA scores: opt: 267,
E():5e-11,(26.4% identity in 390 aa overlap). Also similar
to Rv1260|Z77137|MTCY50.22C from Mycobacterium
tuberculosis (372 aa), FASTA scores: opt: 762, E(): 0,
(40.9% identity in 345 aa overlap). The transcription of
this CDS seems to be activated in macrophages (see
citation below)."
/db_xref="EnsemblGenomes-Gn:Rv0575c"
/db_xref="EnsemblGenomes-Tr:CCP43313"
/db_xref="GOA:O53772"
/db_xref="InterPro:IPR002938"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O53772"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43313.1"
/translation="MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDF
WGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRRMVGDDFTSLPR
GDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRLTFERTAPRDFDLVIGADGLHSNV
RRLVFGPERDFEHYLGCKVAACVVDGYRPRDERSYVLYNTVDRQLARFALRGDRTMFL
FVFRAEHDNPGVAPKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRG
RVLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRRAFDAYEKRLRPFIEG
KQASAAKFIWFFATRTRFGLWFRNVAMRTMNFGPLATLFAGSVRDDFELPDYTW"
gene 669848..671152
/locus_tag="Rv0576"
CDS 669848..671152
/codon_start=1
/transl_table=11
/locus_tag="Rv0576"
/product="Probable transcriptional regulatory protein
(possibly ArsR-family)"
/note="Rv0576, (MTV039.14), len: 434 aa. Probable
transcriptional regulator, ArsR family. N-terminus highly
similar to others e.g. NP_102487.1|NC_002678
transcriptional regulator from Mesorhizobium loti (104
aa); NP_242952.1|NC_002570 transcriptional regulator (ArsR
family) from Bacillus halodurans (109 aa); etc. C-terminal
region (~240-434) shows similarity with D67028_1 from
Rhodococcus rhodochrous (112 aa); and Rv0738 from
Mycobacterium tuberculosis (182 aa). N-terminus also
highly similar to Rv2034 from Mycobacterium tuberculosis
(107 aa). Contains helix-turn-helix motif at aa 23-43
(Score 1628,+4.73 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0576"
/db_xref="EnsemblGenomes-Tr:CCP43314"
/db_xref="GOA:O53773"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR013538"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR017520"
/db_xref="InterPro:IPR023393"
/db_xref="InterPro:IPR034660"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O53773"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43314.1"
/translation="MLEVAAEPTRRRLLQLLAPGERTVTQLASQFTVTRSAISQHLGM
LAEAGLVTARKQGRERYYRLDERGVLRLRALMESFWSDELDRLVADAAHYPPSQGDCA
MPFEKAVVVPLDPTSTFALITQPDRLRRWMAVAARIELRTGGAYRWTVTPGHSAAGTV
IDVDPGKRVVFTWGWEDHGDPPPGGSTVTITLTPVDGGTEVRLVHDGLTAQQAARHAK
GWNHFLDRLVVAGQRGDAGPDEWAAAPDPLDELSCAEATLAVLQHVLRGIGASDLTRQ
TPCTEYDVSQLADHLLRSLAIIGAAAGAQLAPRDVDAPLETQVADAAQAVMEAWRRRG
LAGTVELNSNQVPATVPVGILCLEFLVHAWDFAIATGSQVIASEPVSEYVLAVAGKVI
TPATRNSAGFAAPAAVGSFAPVLDRLIAFTGRQPTAGHVSAT"
gene 671166..671951
/gene="TB27.3"
/gene_synonym="cfp32"
/locus_tag="Rv0577"
CDS 671166..671951
/codon_start=1
/transl_table=11
/gene="TB27.3"
/gene_synonym="cfp32"
/locus_tag="Rv0577"
/product="Conserved protein TB27.3"
/note="Rv0577, (MTV039.15), len: 261 aa. TB27.3, conserved
protein. Corresponds to O53774|CF30_MYCTU 27 kDa antigen
CFP30B from Mycobacterium tuberculosis culture filtrate
(260 aa), FASTA scores: opt: 1781, E(): 0, (100.0%
identity in 260 aa overlap). Also similar to several
hypothetical proteins and hydroxylases from Steptomyces
sp. e.g. T35032 probable hydroxylase from Streptomyces
coelicolor (263 aa); Q55078 orfA gene product from
Streptomyces sp. (275 aa),FASTA scores: E(): 1.5e-1 9,
(38.6% identity in 264 aa overlap); D89734_1|P95754 DNA
for SgaA SGAA protein from Streptomyces griseus; and
SC9B10_20 from Streptomyces coelicolor (267 aa), FASTA
score: (38.9 identity in 252 aa overlap). Also similar to
Rv0911|MTCY21C12.05 from Mycobacterium tuberculosis (257
aa), FASTA scores: E(): 1.1e-20, (32.0% identity in 259 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0577"
/db_xref="EnsemblGenomes-Tr:CCP43315"
/db_xref="GOA:P9WIR3"
/db_xref="InterPro:IPR004360"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="InterPro:IPR041581"
/db_xref="PDB:3OXH"
/db_xref="UniProtKB/Swiss-Prot:P9WIR3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43315.1"
/translation="MPKRSEYRQGTPNWVDLQTTDQSAAKKFYTSLFGWGYDDNPVPG
GGGVYSMATLNGEAVAAIAPMPPGAPEGMPPIWNTYIAVDDVDAVVDKVVPGGGQVMM
PAFDIGDAGRMSFITDPTGAAVGLWQANRHIGATLVNETGTLIWNELLTDKPDLALAF
YEAVVGLTHSSMEIAAGQNYRVLKAGDAEVGGCMEPPMPGVPNHWHVYFAVDDADATA
AKAAAAGGQVIAEPADIPSVGRFAVLSDPQGAIFSVLKPAPQQ"
gene complement(671996..675916)
/gene="PE_PGRS7"
/locus_tag="Rv0578c"
CDS complement(671996..675916)
/codon_start=1
/transl_table=11
/gene="PE_PGRS7"
/locus_tag="Rv0578c"
/product="PE-PGRS family protein PE_PGRS7"
/note="Rv0578c, (MTV039.16c), len: 1306 aa.
PE_PGRS7,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to many other PGRS proteins e.g.
MTCY493.04|Z95844 from Mycobacterium tuberculosis (1329
aa), FASTA scores: opt: 3994, E(): 0, (54.6% identity in
1375 aa overlap). Contains two PS00583 pfkB family of
carbohydrate kinases signatures possibly fortuitously."
/db_xref="EnsemblGenomes-Gn:Rv0578c"
/db_xref="EnsemblGenomes-Tr:CCP43316"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MX28"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43316.1"
/translation="MSFVIATPEMLTTAATDLAKIGSTITAANTAAAAVAKVLPASAD
EVSVAVAALFGTHAQEYQTVSAQVATFHDRFVQTLSAAASSYVAAEAVNVEQSLLAAV
NAPTQALFGRPLIGNGADGSPGTGQAGGPGGILYGNGGNGGSGAPGQRGGAGGAAGLI
GNGGNGGAGGVGTTGGAGGHGGAGGWLYGNGGAGGFGGAGAVGGNGGAGGTAGLFGVG
GAGGAGGNGIAGVTGTSASTPGGSGTAGGAGGIGGNGGAGGAGGVLMGNGGNGGAGGE
GGPGGAGGAGASGAHATNLGADGQAGGNGGNGGAGGTGGVGGPGGGHGLLGLGGSHGA
GGAGGSGGDGGAPGDGGNGATGTWGHNLGAGGTGGNGGNPGAGGAGGAGGASVGGSAH
GANGAPGTTSTSGGNGGDGGKGADAISSGQTGANGGRGGDGGQVGNGGAGGAGGRGGA
GGLGFGSEAPGRPGGAGGTGGAGGNGGTQAGDGGTGGAGGAGGDGGSGGAGSIGFNAS
APGAAGSPGGNGGNGGPGGAGGEGGAGGLALAASGQNGSQGAGGDGGAGGNGGTPGNG
GHGAAGALGVNGGVGGAGGHGGDPGVGGAGGQGGSGSTPGANGAPGNTPTSGGNGGNG
GRGADATGFGQTGASGGRGGDGGLVGNGGAGGAGGNGSKGLPGLGRLGNPGLDGGTGG
NGGAGGSGGAWAGNGGTGGAGGTGGVGGTGGSGSDGVNGSSAGADGHPGGTGGVGGTG
GKGGDGGDGGAAPNGVAGSQGPGGAGGDGGTGGVGGNGGRGIDGADGATAGARGQDGG
AGGAGGKGGRGGTGGPGGAGPAGTTGSQGAGGNGGSGGTGGDPGDGGNGANGSVFTNN
GIGGNGGNGGNAGPSGAGGSGGAGSTFGATGSSSSIHVNGGNGGNGGNGDHALSGNGA
AGGNGGNGGNGSLRGSGGAGGHGGNGGNASRGMGGDGGTGGAGGNAGQIGNGGAGGNG
GDGGTGSDGNPGAITGSGGRGGDGGVGGQGGSVAGDGADGGRGGAGGTGGTGLRGTTG
ATGATGTFDAGADGHGGNGGTGGVGGTGGAGGGGGNGGAGGKALSPTGNNGSQGAGGD
GGAGGAGGTGGTGGDGGRGAHGTLFSSLAGTGGTGGNGGTGGTGGTGGAGGAGGTGST
LGATGATGAAGRAGNGGVGGSGGLGSAFGPGGTGGMGGAGGTSTVSAGGDGGRGGFGG
DGLDASSGGNGGDGGHGGDGFRTAGAGGRGGDGGKGADPGGLFPIPGAGGKGGTGGTG
GTAHLGPLAIIGQSGQPGQFGSPGADGRGGAGGAGGGGGAGGSF"
gene 676238..676996
/locus_tag="Rv0579"
CDS 676238..676996
/codon_start=1
/transl_table=11
/locus_tag="Rv0579"
/product="Conserved hypothetical protein"
/note="Rv0579, (MTV039.17), len: 252 aa. Conserved
hypothetical protein, showing some similarity to others
e.g. AE001747_4 hypothetical protein from Thermotoga
maritima (247 aa), FASTA scores: opt: 612, E(): 0, (39.6%
identity in 235 aa overlap); AE001004_2 hypothetical
protein from Archaeoglobus fulgidus (159 aa), FASTA
scores: opt: 196, E(): 1e-06, (28.3% identity in 159 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0579"
/db_xref="EnsemblGenomes-Tr:CCP43317"
/db_xref="InterPro:IPR002782"
/db_xref="InterPro:IPR027798"
/db_xref="UniProtKB/TrEMBL:O53776"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43317.1"
/translation="MVGYVDVRAYAELNEFVELQARGLTVRRPFRSHQTVKDVLEAMG
IPHTEVDLILVNGDPADFSYRPVAGDRIAAYPMFEALDIGSTARLRPAPLRNPRFVVD
VNLGQLARLLRLLGFDTRWSSAADDPTLADISLGEQRILLTRDRGLLKRRAITHGLFV
HSQHPEEQALEVLRRLDLNGRLAPLSRCLRCNGELAAVSKDEVIGQLEPLTRRYYESF
SRCFGCGRIYWPGSHHARLVRLVERLRDQLTTST"
gene complement(677125..677616)
/locus_tag="Rv0580c"
CDS complement(677125..677616)
/codon_start=1
/transl_table=11
/locus_tag="Rv0580c"
/product="Conserved protein"
/note="Rv0580c, (MTV039.18c), len: 163 aa. Conserved
protein, equivalent to AAA90989.1|U20446|MK35 lipoprotein
precursor from Mycobacterium kansasii (225 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0580c"
/db_xref="EnsemblGenomes-Tr:CCP43318"
/db_xref="GOA:O53777"
/db_xref="InterPro:IPR016791"
/db_xref="UniProtKB/TrEMBL:O53777"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43318.1"
/translation="MTDQSYAVDIAHPPAALLRLVNPILRSLLHTPLAGPLRTQLMVV
SFTGRKTGRHFSIPLSAHVIDNDLYALTEAGWKHNFSDGAAAQVVYDGKTTAMRGELI
RDRAVVSELFLRAAQAYGVKRGQRMLGLSFRDRRIPTLEEFAEAVDRLKLVAIRLTPA
DNS"
gene 677710..677925
/gene="vapB26"
/locus_tag="Rv0581"
CDS 677710..677925
/codon_start=1
/transl_table=11
/gene="vapB26"
/locus_tag="Rv0581"
/product="Possible antitoxin VapB26"
/note="Rv0581, (MTV039.19), len: 71 aa. Possible
vapB26,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0582,see Arcus et al. 2005. Showing weak similarity to
other Mycobacterium tuberculosis proteins including
P95003|Z83863|Rv2550c|MTCY159_6 conserved hypothetical
protein (81 aa), FASTA scores: opt: 93, E(): 3.2, (25.7%
identity in 70 aa overlap); Rv2871; Rv1241; etc. Also
shows weak similarity to X05648|SGSPH_1 from Streptomyces
glaucescens (77 aa), FASTA scores: opt: 92, E():
3.6,(35.4% identity in 65 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0581"
/db_xref="EnsemblGenomes-Tr:CCP43319"
/db_xref="GOA:O53778"
/db_xref="InterPro:IPR002145"
/db_xref="InterPro:IPR010985"
/db_xref="PDB:5X3T"
/db_xref="UniProtKB/Swiss-Prot:O53778"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43319.1"
/translation="MDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKP
PPRGGLYAGSEPIARRVDELLAGFGER"
gene 677922..678329
/gene="vapC26"
/locus_tag="Rv0582"
CDS 677922..678329
/codon_start=1
/transl_table=11
/gene="vapC26"
/locus_tag="Rv0582"
/product="Possible toxin VapC26. Contains PIN domain."
/note="Rv0582, (MTV039.20), len: 135 aa. Possible
vapC26,toxin, part of toxin-antitoxin (TA) operon with
Rv0581,contains PIN domain, see Arcus et al. 2005."
/db_xref="EnsemblGenomes-Gn:Rv0582"
/db_xref="EnsemblGenomes-Tr:CCP43320"
/db_xref="GOA:O53779"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="PDB:5X3T"
/db_xref="UniProtKB/Swiss-Prot:O53779"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43320.1"
/translation="MIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELD
YLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQAARIVTKYQDQRIGIADAANVV
LADRYRTRTILTLDRRHFSALRPIGGGRFTVIP"
gene complement(678389..679075)
/gene="lpqN"
/locus_tag="Rv0583c"
CDS complement(678389..679075)
/codon_start=1
/transl_table=11
/gene="lpqN"
/locus_tag="Rv0583c"
/product="Probable conserved lipoprotein LpqN"
/note="Rv0583c, (MTV039.21c), len: 228 aa. Probable
lpqN,conserved lipoprotein, equivalent to
AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein
precursor from Mycobacterium kansasii (225 aa), FASTA
scores: opt: 945, E(): 0, (62.7% identity in 228 aa
overlap); and similar to others from Mycobacteria e.g.
Rv0040c and Rv1016c from Mycobacterium tuberculosis.
Contains N-terminal signal sequence and appropriately
positioned PS00013 Prokaryotic membrane lipoprotein lipid
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0583c"
/db_xref="EnsemblGenomes-Tr:CCP43321"
/db_xref="GOA:O53780"
/db_xref="InterPro:IPR016123"
/db_xref="InterPro:IPR019674"
/db_xref="UniProtKB/TrEMBL:O53780"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43321.1"
/translation="MKHFTAAVATVALSLALAGCSFNIKTDSAPTTSPTTTSPTTSTT
TTSATTSAQAAGPNYTIADYIRDNHIQETPVHHGDPGSPTIDLPVPDDWRLLPESSRA
PYGGIVYTQPADPNDPPTIVAILSKLTGDIDPAKVLQFAPGELKNLPGFQGSGDGSAA
TLGGFSAWQLGGSYSKNGKLRTVAQKTVVIPSQGAVFVLQLNADALDDETMTLMDAAN
VIDEQTTITP"
gene 679229..681862
/locus_tag="Rv0584"
CDS 679229..681862
/codon_start=1
/transl_table=11
/locus_tag="Rv0584"
/product="Possible conserved exported protein"
/note="Rv0584, (MTV039.22), len: 877 aa. Possible
conserved exported protein, similar to other hypothetical
proteins which are not necessarily secreted e.g.
CAB61925.1|AL133278 putative secreted protein from
Streptomyces coelicolor (772 aa);
AAD51075.1|AF175722_1|AF175722 immunoreactive 89kD antigen
PG87 from Porphyromonas gingivalis (781 aa), FASTA scores:
opt: 637, E(): 2.1e-30, (29.1% identity in 794 aa
overlap); etc. Contains PS00699 Nitrogenases component 1
alpha and beta subunits signature 1. Has potential
N-terminal signal peptide. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0584"
/db_xref="EnsemblGenomes-Tr:CCP43322"
/db_xref="GOA:O86365"
/db_xref="InterPro:IPR005887"
/db_xref="InterPro:IPR008928"
/db_xref="InterPro:IPR012939"
/db_xref="InterPro:IPR014718"
/db_xref="InterPro:IPR041371"
/db_xref="UniProtKB/Swiss-Prot:O86365"
/inference="protein motif:PROSITE:PS00699"
/protein_id="CCP43322.1"
/translation="MRARRLRRALAALLAVAGLFVPFIVGVPTAYDGEPVFVAIPVEH
VNTLIGTGTGAAIVGEINNFPGASVPFGMVQYSPDTVDNYAGYDYDNPHSTGFSMTHA
SVGCPAFGDISMLPTTTPLGSQPWSAWEEIAHDDTEVGVPGYYTVRFPGTGVIAELTA
TTRTGVGRFRYPRNGWPALFHVRSGASLAGNYAATLQIEDNTTITGSATSGGFCGKKN
LYTVYFAMKFSQPFSSYGTWDGYAVYPGSHSMNSSYSGGYVGFPAGSVLEVRTALSYV
SVDGARANLDAEGGASFDDIRAATSSEWNAALSRIAVAGRGPGDVDTFYTCLYRSLLH
PNTFNDVDGRYIGFDGVIHSVASGHTHYANFSDWDTYRSLAPLQGLLFPQRASDMIQS
LVTDAEQSGAYPRWALANSATGMMSGDSVVPLIVNLYAFGARDFDLKSALHYMVNAAT
QGGVGLDGFLERPGIAAYLRLGYGPQTAEFRANGRIAGASVTLEWSVDDFAISRFADS
LGDTATAAVFQNRSQYWQNLFNPTTGYISPRSAAGFFPDGPGFVAYPSGFGQDGYDEG
NAEQYLWWVPHNVAGLVTALGGRTAVVKRLDRFTKKLNVGPNEPYLWAGNEPGFGVPW
LYNYIGQPWKTQRTVDRVRGLFGPTPGGAPGNDDLGALSSWYVWAALGLYPSTPGTTI
LTVNTPLFDRAVIALPTGKSIQITAPGASGRNRLKYIDGLTIDRQPSNQTFLPESIVR
TGGDLTFSLAGTPNKVWGTAASAAPPSFGAGSSAVTVNIARPIIGIVPGATGTVTVDA
QRMIDGVDDYTVTPTSYVVGIAAEPLSGQFDDDGAVSASVAITVARSVPSGYYPIYVT
TSAGDSARTLIVLVVVAEAVE"
gene complement(681885..684272)
/locus_tag="Rv0585c"
CDS complement(681885..684272)
/codon_start=1
/transl_table=11
/locus_tag="Rv0585c"
/product="Probable conserved integral membrane protein"
/note="Rv0585c, (MTV039.23c, MTCY19H5.37), len: 795 aa.
Probable conserved integral membrane protein. C-terminus
similar to CAB88984.1|AL353864 putative integral membrane
protein from Streptomyces coelicolor (299 aa); and
C-terminal region of CAC01311.1|AL390968 putative integral
membrane protein from Streptomyces coelicolor (925 aa).
Also some similarity with Rv0204 from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0585c"
/db_xref="EnsemblGenomes-Tr:CCP43323"
/db_xref="GOA:O53781"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR022791"
/db_xref="UniProtKB/TrEMBL:O53781"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43323.1"
/translation="MRVDGRDIGVSGNLLQPLTRRTNDIIRAVLAAIYLVAVITSSLI
TRPQWVALEKSISEIVGVLSPSQSDLVYLGYGLAILALPFVILIGLIVSRQWKLLGAY
AAAGLMAVLPLSISSSRIAAPRWHFDLSDRLATLLAQFLDDPRWIAMLAAVLTVSGPW
LPARWRHWWWALLLAFVPIHLVVSAIVPARSLLGLAVGWLVGALVVLVVGTPALEVPL
DGAIRALAKRGFAVSGLAVVRPAGPGPLVLSAACEQPNAGACSEALIELYGPHQSGGG
ALRQLWLKLTLRGTETAPLQASMRRAVEHRALMAIAFGDLGMANTTVIAVSPLDRGWT
LYAHRPARGIGISECTKTTPTAHVWEALRTLHDQQISHGDLCSAEITVDNGAVLFGGF
GEAEYGATDAQLQSDLAQLLVTTSALYDAEAAVTAAIDTFGKQAILAASRRLTKSAVP
KRIRESITDPNAVIASTRAEVMRQTGADQIKAETITRFSRGQLIQLVLIGALVYVAYP
FISTVPTFFSQLRTANWWWALLGLAVSALTYVGAAAALWACADGLVGFWKLSIMQVAN
TFAATTTPAGVGGLALSTRFLQKGGLTAVRATAAVALQQSVQVIVHLVLLILFSALAG
TSTDLSHFVPNATVLYLIAGVALGIVGTFLFVPKLRRWLATAVRPKLREVTNDLIALA
REPKRLALIVLGCAGTTLGAALALWASIEAFGGGTTFVTVTVVTMVGGTLASAAPTPG
GVGAVEAALIGGLAAFGVPAALGVPSVLLYRLLTCWLPVFAGWQVMHWLTRHEMI"
gene 684410..685132
/gene="mce2R"
/locus_tag="Rv0586"
CDS 684410..685132
/codon_start=1
/transl_table=11
/gene="mce2R"
/locus_tag="Rv0586"
/product="Probable transcriptional regulatory protein
Mce2R (GntR-family)"
/note="Rv0586, (MTCY19H5.36c), len: 240 aa. Probable
mce2R,transcriptional regulator, GntR family, part of mce2
operon, similar to many e.g. P33233|LLDR_ECOLI putative
L-lactate dehydrogenase operon regulatory protein from
Escherichia coli (258 aa), FASTA scores: opt: 225, E():
9.3e-08, (26.7% identity in 232 aa overlap); etc. Also
similar to other M. tuberculosis transcriptional
regulators GntR proteins e.g. Rv3060c, Rv0792c, etc.
Contains PS00043 Bacterial regulatory proteins, gntR
family signature and probable helix-turn helix motif from
aa 35-56 (Score 1531,+4.40 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0586"
/db_xref="EnsemblGenomes-Tr:CCP43324"
/db_xref="GOA:P9WMG5"
/db_xref="InterPro:IPR000524"
/db_xref="InterPro:IPR008920"
/db_xref="InterPro:IPR011711"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMG5"
/inference="protein motif:PROSITE:PS00043"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43324.1"
/translation="MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELL
GVSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGELDISVVR
SILEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVD
SAGSIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAA
QDLLELANTSLMAVLVSQASRQ"
gene 685129..685926
/gene="yrbE2A"
/locus_tag="Rv0587"
CDS 685129..685926
/codon_start=1
/transl_table=11
/gene="yrbE2A"
/locus_tag="Rv0587"
/product="Conserved hypothetical integral membrane protein
YrbE2A"
/note="Rv0587, (MTCY19H5.35c), len: 265 aa.
YrbE2A,hypothetical unknown integral membrane protein,
part of mce2 operon and member of YrbE family (see
citations below), highly similar to Mycobacterium
tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265
aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also
highly similar to conserved hypothetical integral membrane
proteins of the yrbEA type, e.g. P45392|YRBE_ECOLI
hypothetical 27.9 kDa protein from Escherichia coli (260
aa), FASTA scores: opt: 287, E(): 6.1e-12, (21.5% identity
in 256 aa overlap); P45030|YRBE_HAEIN|HI1086 hypothetical
protein from Haemophilus influenzae (261 aa), FASTA
scores: opt: 311, E(): 1.8e-83, (24.2% identity in 265 aa
overlap); NP_302654.1|NC_002677 conserved membrane protein
from Mycobacterium leprae (267 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0587"
/db_xref="EnsemblGenomes-Tr:CCP43325"
/db_xref="GOA:I6Y870"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:I6Y870"
/protein_id="CCP43325.1"
/translation="MTTHAVIITYLRDQTQPAVDAIGGFYRTCVLTGKALVRRPFHWR
EAIEQGWFITSVSLLPTLAVSIPLTVLIIFTLNILLAEFGAADISGAGAALGAVTQLG
PLTTVLVIAGAGATAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVVAATIVAALL
NGAVITIGLVGGFVFSVFIQHVSAGAYVGTLTLVTGLPEVIISVVKSATFGLIAGLVG
CYRGLTTKGGPKGVGTAVNETLVLCVIALFATNVVLTTIGVRFGTGH"
gene 685928..686815
/gene="yrbE2B"
/locus_tag="Rv0588"
CDS 685928..686815
/codon_start=1
/transl_table=11
/gene="yrbE2B"
/locus_tag="Rv0588"
/product="Conserved hypothetical integral membrane protein
YrbE2B"
/note="Rv0588, (MTCY19H5.34c), len: 295 aa.
YrbE2B,hypothetical unknown integral membrane protein,
part of mce2 operon and member of YrbE family (see
citations below), highly similar to Mycobacterium
tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289
aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also
highly similar to conserved hypothetical integral membrane
proteins of the yrbEB type, e.g. P45392|YRBE_ECOLI
hypothetical 27.9 kDa protein from Escherichia coli (260
aa), FASTA scores: opt: 232, E(): 8.4e-08, (22.1 %
identity in 267 aa overlap); P45030|YRBE_HAEIN|HI1086
hypothetical protein from Haemophilus influenzae (261 aa),
FASTA scores: opt: 234, E(): 6.3e-08, (24.2% identity in
215 aa overlap); NP_302655.1|NC_002677 conserved membrane
protein from Mycobacterium leprae (289 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0588"
/db_xref="EnsemblGenomes-Tr:CCP43326"
/db_xref="GOA:O07790"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:O07790"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43326.1"
/translation="MVESSTASAAAVLRARYPRTAASLDRYGGGTARRLERTGTFARF
TRISVVQIGWALRRYRRETLRLVAEIGMGTGAMAVVGGTVAIIGFVTLSGGSLIAIQG
FASLGNIGVEAFTGFFAALANTRVAAPIVSGVALAATVGAGATAQLGAMRISEEIDAL
EVMGIKSISFLVSTRILGGLVVIMPLYALALDMAFTSGQVVTTVFYGQSNGTYEHYFR
TFLRPEDVGWSVVEVVIIAVVVMITHCYYGYTASGGPVGVGQAVGRSMRFSLVSVVVV
VLLAELALYGVDPNFNLTV"
gene 686821..688035
/gene="mce2A"
/gene_synonym="mce2"
/locus_tag="Rv0589"
CDS 686821..688035
/codon_start=1
/transl_table=11
/gene="mce2A"
/gene_synonym="mce2"
/locus_tag="Rv0589"
/product="Mce-family protein Mce2A"
/note="Rv0589, (MTCY19H5.33c), len: 404 aa. Mce2A; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa);
O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also
highly similar to others e.g.
AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry
protein from Mycobacterium bovis BCG (454 aa);
NP_302656.1|NC_002677 putative cell invasion protein from
Mycobacterium leprae (441 aa); CAC12798.1|AL445327
putative secreted protein from Streptomyces coelicolor
(418 aa); etc. Also highly similar, but longer 21 aa, to
P72013|CAA50257.1|X70901|MTCI28.08 Mcep protein from
Mycobacterium tuberculosis (432 aa), FASTA scores: opt:
1324, E(): 0, (62.6% identity in 436 aa overlap). Contains
a possible N-terminal signal or anchor sequence. Predicted
to be an outer membrane protein (See Song et al., 2008).
Note that previously known as mce2."
/db_xref="EnsemblGenomes-Gn:Rv0589"
/db_xref="EnsemblGenomes-Tr:CCP43327"
/db_xref="GOA:Q79FY7"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="InterPro:IPR024516"
/db_xref="UniProtKB/TrEMBL:Q79FY7"
/protein_id="CCP43327.1"
/translation="MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTPKT
ELTMVAFRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLDVNPRYISLIP
VNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVGSVTTEFNTLFETITSIAE
KVDPIELNATLSAVAQALDGLGGKFGESIVNGNQILAQLNPRLPQLGYDVRRLADLGE
VYVDASPDLWSFLQNALTTARTLTSQQRDLDAALLAATGAGNTGEDVFARGGPYLARA
AADLVPTATLLDTYSPELFCMIRNFHDAAPKVADAVGGNGYSLAAAGTILGAPNPYVY
PDNLPRVNAHGGPGGRPGCWQTITRELWPAPYLVMDTGASLAPYNHVELGQPMFTEYV
WGRQYGENTINP"
gene 688032..688859
/gene="mce2B"
/locus_tag="Rv0590"
CDS 688032..688859
/codon_start=1
/transl_table=11
/gene="mce2B"
/locus_tag="Rv0590"
/product="Mce-family protein Mce2B"
/note="Rv0590, (MTCY19H5.32c), len: 275 aa. Mce2B; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07414|Rv0170|MTCI28.10|mce1B (346 aa);
O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly
similar to others e.g. NP_302657.1|NC_002677 putative
secreted protein from Mycobacterium leprae (346 aa);
P45391|YRBD_ECOLI hypothetical 19.6 kDa protein from
Escherichia coli (183 aa), FASTA scores: opt: 160, E():
0.00099, (28.3% identity in 166 aa overlap);
P45029|YRBD_HAEIN|HI1085 hypothetical protein from
Haemophilus influenzae (167 aa), FASTA scores: opt:
135,E():0.035, (25.9% identity in 143 aa overlap); etc.
Contains possible N-terminal signal or anchor sequence.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0590"
/db_xref="EnsemblGenomes-Tr:CCP43328"
/db_xref="GOA:O07788"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O07788"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43328.1"
/translation="MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFT
HVSGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYLNL
IGDRYLELGRGHSGQRLAPGATIPLEHTHPALDLDALLGGFRPLFQTLDPDKVNSIAS
SIITVFQGQGATINDILDQTASLTATLADRDHAIGEVVNNLNTVLATTVKHQTEFDRT
VDKLEVLITGLKNRADPLAAAAAHISSAAGTLADLLGRIVHCCTAASGTSRASSSRS"
gene 688808..689062
/locus_tag="Rv0590A"
CDS 688808..689062
/codon_start=1
/transl_table=11
/locus_tag="Rv0590A"
/product="Mce-family related protein"
/note="Rv0590A, len: 84 aa. Probable continuation of
mce2B|Rv0590. Can find no frameshift to account for this.
Possible nucleotide G missing at 688793 as there are 5 in
Mycobacterium bovis but only 4 in CDC1551. Strong
similarity to C-terminus of other Mce proteins e.g.
AL583926|AL583926_38 from Mycobacterium leprae strain tn
(346 aa), FASTA scores: E(): 1.2e-20, (67.85% identity in
84 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0590A"
/db_xref="EnsemblGenomes-Tr:CCP43329"
/db_xref="GOA:I6X9D2"
/db_xref="UniProtKB/TrEMBL:I6X9D2"
/protein_id="CCP43329.1"
/translation="MLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIGRAGGIY
GDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQPTGRCTPQ"
gene 689059..690504
/gene="mce2C"
/locus_tag="Rv0591"
CDS 689059..690504
/codon_start=1
/transl_table=11
/gene="mce2C"
/locus_tag="Rv0591"
/product="Mce-family protein Mce2C"
/note="Rv0591, (MTCY19H5.31c), len: 481 aa. Mce2C; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07415|R0171|MTCI28.11|mce1C (515 aa);
O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly
similar to others e.g. NP_302658.1|NC_002677 putative
secreted protein from Mycobacterium leprae (519 aa);
CAC12796.1|AL445327 putative secreted protein from
Streptomyces coelicolor (351 aa); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop), and may contain
N-terminal signal or anchor sequence. Has highly Pro-rich
C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0591"
/db_xref="EnsemblGenomes-Tr:CCP43330"
/db_xref="GOA:O07787"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O07787"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43330.1"
/translation="MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYA
QFADTGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLPGKTIGMQSRAAIRTDTI
LGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDAFVDVTKAATGWDIDAVKRSLNV
LSETFDQTAPHLSAALEGVKAFSDTVGRRGEQIEQLLANANRIARVLGDRSEQVNGLL
VNAKTLLAAFKQRSQALRILLTNVSEASAQVSGLITDNPNLNHVLAQLRTVSEELVKR
KNELADVAVLLGRYTAALTEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPEN
FWRSAGLPEFRWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTPAAGAL
PRPDTPLPCAGATVGPFGGPDFPAPLDVQPSPPNPDGPPPTPGILSAGRPGEPAPAVP
GIPMPLPPNAPPGARTQPLEPFPDGTGGSNQ"
gene 690501..692027
/gene="mce2D"
/locus_tag="Rv0592"
CDS 690501..692027
/codon_start=1
/transl_table=11
/gene="mce2D"
/locus_tag="Rv0592"
/product="Mce-family protein Mce2D"
/note="Rv0592, (MTCY19H5.30c), len: 508 aa. Mce2D; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07416|Rv0172|MTCI28.12|mce1D (530 aa);
O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly
similar to others e.g. NP_302659.1|NC_002677 putative
secreted protein from Mycobacterium leprae (531 aa);
CAC12795.1|AL445327 putative secreted protein from
Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich
C-terminus and may contain N-terminal signal or anchor
sequence. Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0592"
/db_xref="EnsemblGenomes-Tr:CCP43331"
/db_xref="GOA:I6WYT7"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:I6WYT7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43331.1"
/translation="MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKL
TTTTVVAYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPATAT
ASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRDSINGILRQLG
PTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALTALNEGRGDFVAITRSLAL
FVSALYQNDQQFVALNENLAEFTDWFTKSDHDLADTVERIDDVLGTVRKFVSDNRSVL
AADVNNLADATTTLVQPEPRDGLETALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFA
NPIQLICSAIQAGSRLGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEV
AYSEERLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANMLTP
ESLAELLGGPDIAPPPPGTNLPGPPNAYDESNPLPPPWYPQPASLPAAGATGQPGPGQ
"
gene 692024..693232
/gene="lprL"
/gene_synonym="mce2E"
/locus_tag="Rv0593"
CDS 692024..693232
/codon_start=1
/transl_table=11
/gene="lprL"
/gene_synonym="mce2E"
/locus_tag="Rv0593"
/product="Possible Mce-family lipoprotein LprL (Mce-family
lipoprotein Mce2E)"
/note="Rv0593, (MTCY19H5.29c), len: 402 aa. Possible lprL
(alternate gene name: mce2E), lipoprotein which belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E
(390 aa); O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa);
etc. Also highly similar to others e.g.
NP_302660.1|NC_002677 putative lipoprotein from
Mycobacterium leprae (392 aa); CAC12794.1|AL445327
putative secreted protein from Streptomyces coelicolor
(413 aa); etc. Contains possible signal sequence and
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site."
/db_xref="EnsemblGenomes-Gn:Rv0593"
/db_xref="EnsemblGenomes-Tr:CCP43332"
/db_xref="GOA:I6Y461"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:I6Y461"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP43332.1"
/translation="MRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVLT
SCTWRGIANVPLPVGRGMGPDRMTIYVQMPDTLALNTNSRVRVADVWVGTVRDISLRN
WIATLTLELEPTVRLPANATAKIGQTSLLGTQHVELAAPPIPSPQPLKSGDTIGLKNS
SAYPTVERTLASVALILTGGGIVNLDVIQTEILNILDGHAGQIREFLERLATFTAELN
NQRGDLTRAIDSTNQLLTIIANRNDTLDRVLTDVPPLIEHFADTGQLFADATESLGRF
SEVANRALAATRPNLHQTLQSLQRPLRQLERASPYVVGALKLGLTAPFNIDEVPNVIR
GDYVNVSATFDVTLSALDNALLSGTGISGMLRALEQAWGRDPDTMIPDVRYTPNPNDA
PGGPLVERAE"
gene 693237..694787
/gene="mce2F"
/locus_tag="Rv0594"
CDS 693237..694787
/codon_start=1
/transl_table=11
/gene="mce2F"
/locus_tag="Rv0594"
/product="Mce-family protein Mce2F"
/note="Rv0594, (MTCY19H5.28c), len: 516 aa. Mce2F; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), similar to Mycobacterium
tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515
aa); O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also
highly similar to others e.g. NP_302661.1|NC_002677
putative secreted protein from Mycobacterium leprae (516
aa); AAF74993.1|AF143400_1|AF143400|996A027a protein from
Mycobacterium avium (80 aa) (similarity on C-terminus);
CAC12793.1|AL445327 putative secreted protein from
Streptomyces coelicolor (433 aa); etc. Contains possible
N-terminal signal or anchor sequence. Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0594"
/db_xref="EnsemblGenomes-Tr:CCP43333"
/db_xref="GOA:O07784"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="InterPro:IPR024516"
/db_xref="UniProtKB/TrEMBL:O07784"
/protein_id="CCP43333.1"
/translation="MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVGIGRYTLYA
ELPRSGGLYRTANVTYRGITIGKVTGVEPTERGARATMSIDNGYQIPTDASANVHSVS
AVGEQFVDLVSTRTSGPYLRHGQTITTTTVPSQIGPALDAANRGLAVLPKDRVASVLH
EASEAVGGLGSSLNRLIEATQAIAHDVRGSLEDIDDIIERSAPIIDSQVNSGNEIARW
AANLNTLAAQTAQTDPAVRSILANAAPTADQVNATFSDVRESLPQTLANLEVVIDMLK
RYHNGVEQALVFLPQSGAIAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPASEWRS
PADTSTAPLPKGTYCRIPMDASNVVRGARNNPCVDVPGKRAATPRECRSNEAYVPGGT
NPWYGDPNQMLSCPAPAARCDQPVKPGQVIPAPSVNNGINPLPADQLPGTPPPVNDPL
QRPGSGTVQCNGQQPNPCVYTPSTFPTTIYDVQSGKVVAPDGVVYSVEASTHAGADGW
KVMLAPTG"
gene complement(694839..695231)
/gene="vapC4"
/locus_tag="Rv0595c"
CDS complement(694839..695231)
/codon_start=1
/transl_table=11
/gene="vapC4"
/locus_tag="Rv0595c"
/product="Possible toxin VapC4"
/note="Rv0595c, (MTCY19H5.27), len: 130 aa. Possible
vapC4,toxin, part of toxin-antitoxin (TA) operon with
Rv0596c,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to other conserved
hypothetical proteins e.g. Rv0627 (135 aa) and Rv0665 (112
aa) from Mycobacterium tuberculosis; and STBB_PSESM|Q52562
plasmid stability protein from Pseudomonas syringae (139
aa), FASTA scores: opt: 131, E(): 0.0035, (35.2% identity
in 88 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0595c"
/db_xref="EnsemblGenomes-Tr:CCP43334"
/db_xref="GOA:O07783"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:O07783"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43334.1"
/translation="MNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLG
VLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAWALLVSKLRAAKLRVPINDSWIA
ATAVAHGIAILTQDNDYAAMPDVEVITI"
gene complement(695228..695485)
/gene="vapB4"
/locus_tag="Rv0596c"
CDS complement(695228..695485)
/codon_start=1
/transl_table=11
/gene="vapB4"
/locus_tag="Rv0596c"
/product="Possible antitoxin VapB4"
/note="Rv0596c, (MTCY19H5.26), len: 85 aa. Possible
vapB4,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0595c (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Highly similar in part to other M. tuberculosis
hypothetical proteins e.g. Rv0626, Rv3181c, Rv3385c,
Rv3407, etc. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0596c"
/db_xref="EnsemblGenomes-Tr:CCP43335"
/db_xref="GOA:P9WF21"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:P9WF21"
/protein_id="CCP43335.1"
/translation="MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKR
RRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTTDDVRW"
gene complement(695668..696903)
/locus_tag="Rv0597c"
CDS complement(695668..696903)
/codon_start=1
/transl_table=11
/locus_tag="Rv0597c"
/product="Conserved hypothetical protein"
/note="Rv0597c, (MTCY19H5.25), len: 411 aa. Conserved
hypothetical protein, highly similar to Rv3179 conserved
hypothetical protein from Mycobacterium tuberculosis (429
aa). Also similar to AAF76191.1|AF271296_1|AF271296
putative ATP/GTP binding protein from Mycobacterium
smegmatis (428 aa); Rv2008c|YW09_MYCTU|Q10849 conserved
hypothetical protein from Mycobacterium tuberculosis (441
aa), FASTA scores: opt: 270, E(): 3.6e-11, (30.5% identity
in 416 aa overlap) (N-terminus longer). Also similar to
other hypothetical proteins e.g. NP_085874.1|NC_002679
hypothetical protein from Mesorhizobium loti (435 aa)
(N-terminus longer). Contains PS00017 ATP/GTP-binding site
motif A (P-loop). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0597c"
/db_xref="EnsemblGenomes-Tr:CCP43336"
/db_xref="InterPro:IPR025420"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041682"
/db_xref="UniProtKB/TrEMBL:I6WYU2"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43336.1"
/translation="MGVVERAIAPSVLAALADTPVVVVNGARQVGKTTLVARLDYPGS
SEVVSLDDVANRDAARDDPRAFVSRPVDTLVIDEAQLEPGLFRAIKAEVDRDRRPGRF
LLTGSARLLSAPDMADALVGRVEIIELWPFSQGERAGIADGFVDALFTAPRELIHGSD
MRRADLVDRIATGGFPDIVARSPSRRRAWFDNYLTTATQSVIREISPIERLAEMPRVL
RLCAARTGAELNVSALANDLSIPARTTAGYLALLEAAFLIHRVPAWSTNLSRKVIRRP
KLVVSDSGLACHLLGVTGATLDRPGRPLGPLLETFVANEIRKQLTWSTERPSLWHFRD
RGGAEVDLVLEHPDGRVCGIEVKATSTPRAEDLRGLRYLAERLDDRFQFGVLLTAAPE
ATPFGPTLAALPVSTLWAG"
gene complement(697154..697567)
/gene="vapC27"
/locus_tag="Rv0598c"
CDS complement(697154..697567)
/codon_start=1
/transl_table=11
/gene="vapC27"
/locus_tag="Rv0598c"
/product="Possible toxin VapC27. Contains PIN domain."
/note="Rv0598c, (MTCY19H5.24), len: 137 aa. Possible
vapC27, toxin, part of toxin-antitoxin (TA) operon with
Rv00599c, contains PIN domain, see Arcus et al. 2005.
Similar to others e.g. Rv2596|Y0B5_MYCTU|Q50625 conserved
hypothetical protein from Mycobacterium tuberculosis (134
aa), FASTA scores: opt: 254, E(): 8.2e-12, (41.5% identity
in 130 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0598c"
/db_xref="EnsemblGenomes-Tr:CCP43337"
/db_xref="GOA:P9WF83"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43337.1"
/translation="MKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAE
TYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSRTTEHLPRVLAQFEITGGAVYDA
LVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA"
gene complement(697564..697800)
/gene="vapB27"
/locus_tag="Rv0599c"
CDS complement(697564..697800)
/codon_start=1
/transl_table=11
/gene="vapB27"
/locus_tag="Rv0599c"
/product="Possible antitoxin VapB27"
/note="Rv0599c, (MTCY19H5.23), len: 78 aa. Possible
vapB27,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0598c, see Arcus et al. 2005. Similar to others e.g.
Rv2595|Y0B6_MYCTU|Q50626 conserved hypothetical protein
from Mycobacterium tuberculosis (81 aa), FASTA scores:
opt: 160, E(): 6.2e-07, (35.8% identity in 81 aa overlap).
N-terminus shows stong similarity with N-terminus of
NP_104908.1|NC_002678 hypothetical protein from
Mesorhizobium loti (89 aa). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0599c"
/db_xref="EnsemblGenomes-Tr:CCP43338"
/db_xref="GOA:O07779"
/db_xref="InterPro:IPR007159"
/db_xref="InterPro:IPR037914"
/db_xref="UniProtKB/Swiss-Prot:O07779"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43338.1"
/translation="MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTG
RTARLEEENGVLVATGETTIDDEVVFGLIDSGRK"
gene complement(697904..698410)
/locus_tag="Rv0600c"
CDS complement(697904..698410)
/codon_start=1
/transl_table=11
/locus_tag="Rv0600c"
/product="Two component sensor kinase [second part]"
/note="Rv0600c, (MTCY19H5.22), len: 168 aa (probable
partial CDS). Two-component sensor kinase (second
part),similar to part (C-termini) of many others e.g.
Q04943|AFQ2_STRCO sensor protein afsq2 from Streptomyces
coelicolor (535 aa), FASTA scores: opt: 347, E():
1.9e-12,(33.0% identity in 206 aa overlap); etc. Note that
sequence was checked and no errors were detected, which
would allow this and the upstream ORF to be joined. Start
changed since first submission (- 39 aa). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0600c"
/db_xref="EnsemblGenomes-Tr:CCP43339"
/db_xref="GOA:O07778"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:O07778"
/protein_id="CCP43339.1"
/translation="MPITPLLHESVARFAATGADITTRAEPDLFVSIDPDHLRRILTA
VLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRG
SGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPN
REHDTSDQ"
gene complement(698524..698994)
/locus_tag="Rv0601c"
CDS complement(698524..698994)
/codon_start=1
/transl_table=11
/locus_tag="Rv0601c"
/product="Two component sensor kinase [first part]"
/note="Rv0601c, (MTCY19H5.21), len: 156 aa (probable
partial CDS). Two-component sensor kinase (first
part),similar to part (N-termini) of others e.g.
Q0375|CUTS_STRLI cuts protein from streptomyces lividans
(414 aa), FASTA scores: opt: 230, E(): 3.1e-08, (39.1%
identity in 115 aa overlap). Note that the sequence was
checked and no errors were detected that would allow this
and the downstream ORF to be joined. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0601c"
/db_xref="EnsemblGenomes-Tr:CCP43340"
/db_xref="GOA:O07777"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR036097"
/db_xref="UniProtKB/Swiss-Prot:O07777"
/protein_id="CCP43340.1"
/translation="MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVREL
VTILPIVLVIAAVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIA
WLATTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPTS"
gene complement(699038..699799)
/gene="tcrA"
/locus_tag="Rv0602c"
CDS complement(699038..699799)
/codon_start=1
/transl_table=11
/gene="tcrA"
/locus_tag="Rv0602c"
/product="Two component DNA binding transcriptional
regulatory protein TcrA"
/note="Rv0602c, (MTCY19H5.20), len: 253 aa.
tcrA,two-component DNA-binding response regulator, highly
similar to others e.g. NP_107959.1|NC_002678 two-component
response regulator from Mesorhizobium loti (239 aa); etc.
Also similar to many other Mycobacterium tuberculosis
two-component regulators e.g. Q50806|MTCY10G2.16|Rv1033c
response regulator homolog TRCR (TCRV) (257 aa), FASTA
score: (47.4 identity in 232 aa overlap); etc. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0602c"
/db_xref="EnsemblGenomes-Tr:CCP43341"
/db_xref="GOA:O07776"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="UniProtKB/Swiss-Prot:O07776"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43341.1"
/translation="MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTE
EGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTA
RGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSE
HRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRY
LRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR"
gene 699856..700167
/locus_tag="Rv0603"
CDS 699856..700167
/codon_start=1
/transl_table=11
/locus_tag="Rv0603"
/product="Possible exported protein"
/note="Rv0603, (MTCY19H5.19c), len: 103 aa. Possible
exported protein with hydrophobic stretch at aa 7-29. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0603"
/db_xref="EnsemblGenomes-Tr:CCP43342"
/db_xref="PDB:2KGY"
/db_xref="PDB:2LRA"
/db_xref="UniProtKB/TrEMBL:O07775"
/protein_id="CCP43342.1"
/translation="MNRIVQFGVSAVAAAAIGIGAGSGIAAAFDGEDEVTGPDADRAR
AAAVQAVPGGTAGEVETETGEGAAAYGVLVTRPDGTRVEVHLDRDFRVLDTEPADGDG
G"
gene 700239..701189
/gene="lpqO"
/locus_tag="Rv0604"
CDS 700239..701189
/codon_start=1
/transl_table=11
/gene="lpqO"
/locus_tag="Rv0604"
/product="Probable conserved lipoprotein LpqO"
/note="Rv0604, (MTCY19H5.18c), len: 316 aa. Probable
lpqO,conserved lipoprotein, highly similar to Rv2999|lppY
putative lipoprotein from Mycobacterium tuberculosis (321
aa), FASTA scores: opt: 1153, E(): 0, (53.2% identity in
312 aa overlap). Contains probable N-terminal signal
sequence and PS00013 Prokaryotic membrane lipoprotein
lipid attachment site. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0604"
/db_xref="EnsemblGenomes-Tr:CCP43343"
/db_xref="InterPro:IPR011094"
/db_xref="UniProtKB/TrEMBL:I6X9E2"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43343.1"
/translation="MIRRRGARMAALLAAAALALTACAGSDDKGEPDDGGDRGASLAT
TSDADWKPVADILGRTGKLNDGSVYKIGFARSDLSVQTKGVTVAPALSLGSWVAFART
PDGQTMLMGDLVVTEDELASVTDAVQAGGLQQTALHKHLLEQSPPIWWTHIAGHGDAA
DLARAVRSALDATDTPPPASATSGQTSLDLDTAAIDEALGRSGTIAGGVYKFFIARRD
PVTMSGMLIPPSMGLATALNFQPTGNGRAAINGDFVMTAAEVQDVVQALRGGGIDIVA
IHNHGFDEQPRLFYMHFWAENDAVALARTLRAAVDATAAR"
repeat_region complement(701247..701369)
/note="123 bp imperfect direct repeat 2, 92/103 bp
identical to first copy at 709425..709548,
AGCCCCGGCTCGACGCGGCATAGGGTGGCCACCGTGGCCGAAGCGTTCCATGCGACCG
TGCCGTGGCGAGGATCCCGGCCGAACATGGCCCATTGAACGAGGACGTCATCGCACGA
CGCCTGC. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
mobile_element 701384..702767
/mobile_element_type="insertion sequence:IS1536"
/note="IS1536, len: 1384 nt. Partial copy of insertion
sequence IS_1536. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 701406..702014
/locus_tag="Rv0605"
CDS 701406..702014
/codon_start=1
/transl_table=11
/locus_tag="Rv0605"
/product="Possible resolvase"
/note="Rv0605, (MTCY19H5.17c), len: 202 aa. Possible
resolvase for IS_Y349 element, similar to several
Mycobacterial hypothetical proteins and weakly similar to
Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA
scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa
overlap). Contains PS00397 Site-specific recombinases
active site and probable helix-turn helix motif from aa
9-30 (Score 1815, +5.37 SD). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0605"
/db_xref="EnsemblGenomes-Tr:CCP43344"
/db_xref="GOA:I6Y890"
/db_xref="InterPro:IPR006118"
/db_xref="InterPro:IPR006119"
/db_xref="InterPro:IPR036162"
/db_xref="InterPro:IPR041718"
/db_xref="UniProtKB/TrEMBL:I6Y890"
/inference="protein motif:PROSITE:PS00397"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43344.1"
/translation="MACCRNRGMNLAAWAERNGVARVTAYRWFHAGLLPVPARKVGRL
ILVDELASEAGAQPKTAVYARVSSADQKSDLDRQVARVTSWATAEQIPVDKVVTEVGS
VLNGHRRKFPAVLRDLSVTRIVVEHRDRFCRFGSEYVHAALAAQGRELVVVDSAEVDD
DLVWDMTEILTSMCARLYGKRAAQNRAKRAVAAAAVDDHEAA"
gene 702016..702759
/locus_tag="Rv0606"
CDS 702016..702759
/codon_start=1
/transl_table=11
/locus_tag="Rv0606"
/product="Possible transposase (fragment)"
/note="Rv0606, (MTCY19H5.16c), len: 247 aa. Possible
truncated transposase for IS_1536 element, highly similar
to N-terminus of other transposases from Mycobacterium
tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274
.16c putative transposase from Mycobacterium tuberculosis
(460 aa), FASTA scores: opt: 1368, E(): 0, (83.5% identity
in 237 aa overlap); Rv2978c, Rv0922, Rv3827c, etc. Also
similar to N-terminus of MTV002_57|Rv2792 resolvase from
M. tuberculosis (193 aa), FASTA score: (87.4% identity in
238 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0606"
/db_xref="EnsemblGenomes-Tr:CCP43345"
/db_xref="InterPro:IPR021027"
/db_xref="UniProtKB/TrEMBL:O07772"
/protein_id="CCP43345.1"
/translation="MPRLEIPNGWCVQAFRFTLDPTAEQAHALARHFGARRKAYNWTV
AQLKADIQAWRATGAQTAKPSLRVLRKRWNTVKDEVCVNAETGTVWWPECSKEAYADG
IAGAVDAYWNWQQRRAGKRDGKRMGFPRFKKKGRDADRVSFTTGAMRVEPDRRHLTLP
VIGCVRTHENTRRIERLIAKDRARVLAITVRRNGTRLDASVRVLVQRPQQPNVELPES
RIGVDVGVRRLATVATADGACCPVLVPDG"
gene 702813..703199
/locus_tag="Rv0607"
CDS 702813..703199
/codon_start=1
/transl_table=11
/locus_tag="Rv0607"
/product="Hypothetical protein"
/note="Rv0607, (MTCY19H5.15c), len: 128 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0607"
/db_xref="EnsemblGenomes-Tr:CCP43346"
/db_xref="UniProtKB/TrEMBL:O07771"
/protein_id="CCP43346.1"
/translation="MGAWQTADTMGIFQALPDVWGGWRTECWEDRFEEQLIRCNGALR
LPELDLAAGMDSAREWLRDRIFQRFSDSPAGQILKLSELLADVGPGLVVSDDAVTNGG
ARPNNEEWARFVAACDLVRGAHAESA"
gene 703244..703489
/gene="vapB28"
/locus_tag="Rv0608"
CDS 703244..703489
/codon_start=1
/transl_table=11
/gene="vapB28"
/locus_tag="Rv0608"
/product="Possible antitoxin VapB28"
/note="Rv0608, (MTCY19H5.14c), len: 81 aa. Possible
vapB28,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0609,see Arcus et al. 2005. Similar to several others
e.g. Rv0623|P96913|MTCY20H10.04 (84 aa), FASTA scores:
opt: 159,E(): 1.2e-09, (43.0% identity in 86 aa overlap);
Rv2760c (89 aa); Rv1740 (70 aa), etc. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0608"
/db_xref="EnsemblGenomes-Tr:CCP43347"
/db_xref="GOA:P9WJ39"
/db_xref="InterPro:IPR011660"
/db_xref="UniProtKB/Swiss-Prot:P9WJ39"
/protein_id="CCP43347.1"
/translation="MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDD
LAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLPA"
gene 703486..703887
/gene="vapC28"
/locus_tag="Rv0609"
CDS 703486..703887
/codon_start=1
/transl_table=11
/gene="vapC28"
/locus_tag="Rv0609"
/product="Possible toxin VapC28. Contains PIN domain."
/note="Rv0609, (MTCY19H5.13c), len: 133 aa. Possible
vapC28, toxin, part of toxin-antitoxin (TA) operon with
Rv0608, contains PIN domain, see Arcus et al. 2005.
Similar to several Mycobacterium tuberculosis hypothetical
proteins e.g. YW37_MYCTU|Q10874|Rv1982c|MT2034|MTCY39.37
conserved hypothetical protein (139 aa), FASTA scores:
opt: 262, E(): 8.1e-12, (39.1% identity in 128 aa
overlap); MTCY20H10.05|Rv0624|MT0652|MTCY20H10.05
conserved hypothetical protein (131 aa), FASTA score:
(42.9% identity in 126 aa overlap), Rv0565c, Rv3854c, etc.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0609"
/db_xref="EnsemblGenomes-Tr:CCP43348"
/db_xref="GOA:P9WF81"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF81"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43348.1"
/translation="MIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIV
LDSQRDPVISRALDELIEEAEFVVEPVTERQARLARAAYADFGRGSGHPAGLNFGDCL
SYALAIDRREPLLWKGNDFGHTGVQRALDRR"
gene 703830..704057
/locus_tag="Rv0609A"
CDS 703830..704057
/codon_start=1
/transl_table=11
/locus_tag="Rv0609A"
/product="Conserved hypothetical protein"
/note="Rv0609A, len: 75 aa. Conserved hypothetical
protein,highly similar to part of upstream ORF
Rv0612|MTCY19H5.09c conserved hypothetical protein from
Mycobacterium tuberculosis (201 aa), FASTA scores: opt:
154, E(): 1.8e-05, (74.3% identity in 35 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0609A"
/db_xref="EnsemblGenomes-Tr:CCP43349"
/db_xref="UniProtKB/TrEMBL:Q79FY5"
/protein_id="CCP43349.1"
/translation="MEGQRLWAHRRPKGTGSAVIDVSLARRCEAHGYDYFRSDDPVAA
AGFVVSAVWSCGRGPGNATGSGRLPKPLRHS"
repeat_region complement(703912..703985)
/note="74 bp imperfect direct repeat 2, 64/73 bp identical
to first copy at 706790..706863,
CACAGCGGACACCACAAAGCCCGCCGCTGCCACCGGATCGTCGGAACGAAAATAGTCG
TACCCGTGAGCCTCGC. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene 704187..704247
/gene="B55"
ncRNA 704187..704247
/gene="B55"
/product="Putative small regulatory RNA"
/note="B55, putative small regulatory RNA (See Arnvig and
Young, 2009). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/ncRNA_class="other"
gene complement(704752..705909)
/locus_tag="Rv0610c"
CDS complement(704752..705909)
/codon_start=1
/transl_table=11
/locus_tag="Rv0610c"
/product="Hypothetical protein"
/note="Rv0610c, (MTCY19H5.11), len: 385 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0610c"
/db_xref="EnsemblGenomes-Tr:CCP43350"
/db_xref="UniProtKB/TrEMBL:I6Y481"
/protein_id="CCP43350.1"
/translation="MDDELRGLLARYARGELSADDARRAILRYPKWRVAEIDGELETV
ALDDGTPMLIAESSASDGREYSGLELVRDIAPLVGGLSFDPDEPWGSAFRPGALPELQ
NWARTVELEDAVAKPGPGQRDLLYEGPWWVAVSPGTGRPAVHRADGLDVITIMTAPDA
AATFRRTERHRGLDVVRLGPALWGDLAKRSDFDGVRLNPLRPLAQLWPPHVPAMLVAG
CDPRPNAEPLPARTVAEIHLWLDQHGARQEKRELSNRATPVGEVTVARAWWNYDRREI
AFTRVAPASDTEGLGSVPSRILCAGKLRQSIQSKLAGLPRLTWRADAWHRQRAALAVG
WALELEKLVCGERVPFAALRTPEGAHLWHLEPQAFTARAIRKLRDRAASFR"
gene complement(705961..706344)
/locus_tag="Rv0611c"
CDS complement(705961..706344)
/codon_start=1
/transl_table=11
/locus_tag="Rv0611c"
/product="Hypothetical protein"
/note="Rv0611c, (MTCY19H5.10), len: 127 aa. Hypothetical
unknown protein. Note that first start has been taken
although this overlaps slightly with the upstream ORF.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0611c"
/db_xref="EnsemblGenomes-Tr:CCP43351"
/db_xref="InterPro:IPR032568"
/db_xref="UniProtKB/TrEMBL:I6XVR9"
/protein_id="CCP43351.1"
/translation="MPDRPQHPTASRQSSMVSWNHGAAGWLHCVQCGSATNPTACLDW
LPPIHARSGPMYAEHDVVVLTRDVPDKSLIAGDVGAVVGRYAAGGYEVDFTAANGCTV
AVVTLAGDDIRPRRRREIPHVREVA"
gene 706324..706929
/locus_tag="Rv0612"
CDS 706324..706929
/codon_start=1
/transl_table=11
/locus_tag="Rv0612"
/product="Conserved hypothetical protein"
/note="Rv0612, (MTCY19H5.09c), len: 201 aa. Conserved
hypothetical protein, highly similar, but in part, to
downstream ORF Rv0609A conserved hypothetical protein from
Mycobacterium tuberculosis (75 aa); and showing weak
similarity with other hypothetical proteins from
Mycobacterium tuberculosis. Note that first start has been
taken although this overlaps slightly with the upstream
ORF. This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0612"
/db_xref="EnsemblGenomes-Tr:CCP43352"
/db_xref="UniProtKB/TrEMBL:I6X9E8"
/protein_id="CCP43352.1"
/translation="MLGPIRQPRLTVRPGRLPGMIAGVAAKRMNREQFFRAASGLDED
RLRKALWNLYWRGTANMRERIEAELASAGRARPARKIKPPADPDIVGWEVDEFVSLAR
SGAYLGGDRRVSPRERSRWRFTFKRLAAEAQDALRAEDAEPAASALEQLIDLAREADG
YDYFRSDDPVAAAGFVVSDVAAAGHPHFREFAAEIGAAIPP"
repeat_region complement(706790..706863)
/note="74 bp imperfect direct repeat 1, 64/73 bp identical
to second copy at 703912..703985,
CACATCGGACACGACGAAACCCGCCGCTGCCACCGGATCGTCGGAGCGGAAGTAGTCG
TACCCGTCGGCCTCGC. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene complement(706948..709515)
/locus_tag="Rv0613c"
CDS complement(706948..709515)
/codon_start=1
/transl_table=11
/locus_tag="Rv0613c"
/product="Unknown protein"
/note="Rv0613c, (MTCY19H5.08), len: 855 aa. Unknown
protein. Contains a very short region with strong
similarity to several preprotein translocases e.g.
P47847|SECA_LISMO preprotein translocase seca subunit (836
aa), FASTA scores: opt: 138, E(): 0.18, (38.6% identity in
70 aa overlap, and 72.7% identity in 22 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0613c"
/db_xref="EnsemblGenomes-Tr:CCP43353"
/db_xref="GOA:I6Y897"
/db_xref="InterPro:IPR004027"
/db_xref="UniProtKB/TrEMBL:I6Y897"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43353.1"
/translation="MAEAFDATQAVARILAEHGPLSEDDIARRLLDSGVADPDAVLRA
LRLETEWPARQLVDDRWVWLPTLLAGRVFTHRLGADEAVHDMLGVTPDLDPITTLCEH
EEYGRLADGSAARIVLAGYDEELLERRGIPDEAIDPGGALLLEPGTLATLGAAAGDLV
GVRLTAAGLVLERIGTAGADTSVGARLAELVDPDEPAFFPAAVWTACVDDPAAFTEPV
APLREILDQHGLTHEDDWLAPGGFNFDAWRFENRCELLAFRHDLDPNDAVALYTLIKL
HETMSLLLEATDPDELPRDVLATAAETATETGSDSLVDLLGDIGAALADPLLAELLVA
ETVGTDSGGAAALGLLTEMLEPKVPRAARVAVRWLRAVALDRIGDVEAAERELLAAES
MDTEWPLPLLDLARIASDRGDAERGLALLRRAGTEPDHPLVRLLERHRAQPRRDLGRN
EACWCGSGRKYKKCHLGREALPLAERVDWLYAKASQHALSGDWTGLLAEVSYERFRYA
DSDDEDALAAALADPLVLDAVLFEGGAFAEFLEVRGSLLPDDERLLAEQWLLVERSVF
EVEHVQPGEGVIVRDVRTGDTHEVHERAASRQLRAGQLICARPVPAGDTMVFFGGIEP
VALHERAVLIELLDDEPDPVTLVAQLSRRFAPPTLVNTEGDSLAICEASVRVDDPAGI
QGALDGVYDRVDGEEPPRWIEHVTNDGMLRVRATLVLDGDTLRVETNSEPRMDRVLAT
LTRLDPAMTVLDDDRRPLRNTREAAALAEQMPVTGAGAPDPDSPELAAALEEFIRDYE
TSWLDQPIPALDGHTPRQAADDPTRRADLIKLLDTFPAGAGARGGMDADRLRTALGL"
gene 709356..710348
/locus_tag="Rv0614"
CDS 709356..710348
/codon_start=1
/transl_table=11
/locus_tag="Rv0614"
/product="Conserved hypothetical protein"
/note="Rv0614, (MTCY19H5.07c), len: 330 aa. Conserved
hypothetical protein, similar in part to Mycobacterium
tuberculosis hypothetical proteins e.g.
YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c conserved
hypothetical protein (323 aa), FASTA scores: opt: 200,
E(): 0.00016, (28.3% identity in 269 aa overlap);
MTCY9F9_15 FASTA score: (40.3% identity in 144 aa
overlap), Rv1949c,Rv2542, etc. Several start sites are
possible; first start has been chosen. Note that this ORF
overlaps with the upstream ORF. Predicted to be an outer
membrane protein (See Song et al., 2008). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0614"
/db_xref="EnsemblGenomes-Tr:CCP43354"
/db_xref="GOA:O07763"
/db_xref="UniProtKB/TrEMBL:O07763"
/protein_id="CCP43354.1"
/translation="MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPR
LGSHRTLRPRWPPYAAASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLP
GPRTSGTAAERVARHAQAQTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPET
PSIDDTIIGNDNRDTGVRLVDVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMI
LGGDPANLTGQGLADNVQRFVQSLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTN
DWIDRTAQFASGAIVFSIGVLTAETGAGVVAAAAGGVGAATAGVSLLQCLVGSK"
repeat_region complement(709425..709548)
/note="123 bp imperfect direct repeat 1, 92/103 bp
identical to second copy at 701247..701369,
AGCCTCGGCTGGCCGCGGCATAAGGTGGCCACCGTGGCCGAAGCGTTCGATGCGACCC
AAGCCGTGGCGAGAATCCTGGCCGAACATGGCCCATTGAGCGAGGACGACATCGCACG
ACGCCTGC. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
repeat_region 709585..709663
/locus_tag="Rv0614"
/note="79 bp imperfect direct repeat 1, 73/78 bp identical
to second copy at 711624..711702,
TAGGGTTCGGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGACGGACGTGAGCT
GCTGTTCTTTTCGCTGCCCGG. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene 710345..710587
/locus_tag="Rv0615"
CDS 710345..710587
/codon_start=1
/transl_table=11
/locus_tag="Rv0615"
/product="Probable integral membrane protein"
/note="Rv0615, (MTCY19H5.06c), len: 80 aa. Probable
integral membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv0615"
/db_xref="EnsemblGenomes-Tr:CCP43355"
/db_xref="GOA:O07762"
/db_xref="UniProtKB/TrEMBL:O07762"
/protein_id="CCP43355.1"
/translation="MMDVLAAGIAAGALTLAAWGAWRPHYRAASYLVAGAVELALIGL
LVVTGQTLMAISVAFLVALGGPLVVVNHRRAERSRG"
gene complement(710584..710850)
/locus_tag="Rv0616c"
CDS complement(710584..710850)
/codon_start=1
/transl_table=11
/locus_tag="Rv0616c"
/product="Hypothetical protein"
/note="Rv0616c, (MTCY19H5.05), len: 88 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0616c"
/db_xref="EnsemblGenomes-Tr:CCP43356"
/db_xref="UniProtKB/TrEMBL:O07761"
/protein_id="CCP43356.1"
/translation="MRIPGNRQCLLVQVLRQVDGSAHRLILTSLHRDARADAHRYSNG
TDHAGRAADEPAETAHEPCWVAARGLASQASRAMSATYRPSSFI"
gene 710782..711009
/gene="vapB29"
/locus_tag="Rv0616A"
CDS 710782..711009
/codon_start=1
/transl_table=11
/gene="vapB29"
/locus_tag="Rv0616A"
/product="Possible antitoxin VapB29"
/note="Rv0616A, len: 75 aa. Possible vapB29,
antitoxin,part of toxin-antitoxin (TA) operon with Rv0617,
see Arcus et al. 2005. Similar to many others in M.
tuberculosis e.g. Rv2530A (74 aa) 35.9% identity in 78 aa
overlap"
/db_xref="EnsemblGenomes-Gn:Rv0616A"
/db_xref="EnsemblGenomes-Tr:CCP43357"
/db_xref="GOA:P9WJ37"
/db_xref="InterPro:IPR010985"
/db_xref="UniProtKB/Swiss-Prot:P9WJ37"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43357.1"
/translation="MRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPT
ALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ"
gene 711006..711407
/gene="vapC29"
/locus_tag="Rv0617"
CDS 711006..711407
/codon_start=1
/transl_table=11
/gene="vapC29"
/locus_tag="Rv0617"
/product="Possible toxin VapC29. Contains PIN domain."
/note="Rv0617, (MTCY19H5.04c), len: 133 aa. Possible
vapC29, toxin, part of toxin-antitoxin (TA) operon with
Rv0616A, contains PIN domain, see Arcus et al. 2005.
Similar to others in Mycobacterium tuberculosis e.g.
Rv2494, Rv3320c, Rv0749, Rv0277c, Rv2530c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0617"
/db_xref="EnsemblGenomes-Tr:CCP43358"
/db_xref="GOA:P9WF79"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF79"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43358.1"
/translation="MTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGS
LVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALSFAGVEVAGVVGHRQVTDAYLAQ
LARSHDGQLATLDSGLAHLHGDVAVLIPTTT"
gene 711536..712231
/gene="galTa"
/gene_synonym="galT'"
/locus_tag="Rv0618"
CDS 711536..712231
/codon_start=1
/transl_table=11
/gene="galTa"
/gene_synonym="galT'"
/locus_tag="Rv0618"
/product="Probable galactose-1-phosphate
uridylyltransferase GalTa [first part]"
/note="Rv0618, (MTCY19H5.03c), len: 231 aa (probable
partial CDS). Probable galTa, first part of
galactose-1-phosphate uridylyltransferase, highly similar
to N-terminal half of other galT proteins e.g.
P13212|GAL7_STRLI galactose-1-phosphate
uridylyltransferase from Streptomyces lividans (354 aa),
FASTA scores: opt: 296, E(): 1.4e-11, (50.8% identity in
177 aa overlap); etc. Also highly similar to N-terminal
half of some UDP glucose--hexose-1-phosphate
uridylyltransferases. N-terminal 28 aa similar to
MTCY20H11.08|Rv0627|MTCY20H11.08 conserved hypothetical
protein from Mycobacterium tuberculosis (135 aa), FASTA
score: (71.4% identity in 28 overlap). Cosmid sequence is
correct but there may be a frameshift mutation in this
region which would allow the two ORFs to be joined.
Belongs to the galactose-1-phosphate uridylyltransferase
family 1. Note that previously known as galT'."
/db_xref="EnsemblGenomes-Gn:Rv0618"
/db_xref="EnsemblGenomes-Tr:CCP43359"
/db_xref="GOA:Q79FY4"
/db_xref="InterPro:IPR001937"
/db_xref="InterPro:IPR005849"
/db_xref="InterPro:IPR036265"
/db_xref="UniProtKB/TrEMBL:Q79FY4"
/protein_id="CCP43359.1"
/translation="MSATPPPGGLDASVFIANERGRQLDEALPVGFCVVTAPTRWTLA
DGRDLLFFSLPGHVPAPVSDRRPLPERDPAPSRLRFDRATGQWVIVAAQRQDRTYKPP
AARCPLCPGPTGLSSEVPAPDYDVVVFENRFPSLAGAGIAPIGAPDGDGFVSAPGHGR
CEVICFSADHTGSFAGLDPAHARLVVHAWRHRTAELTALPGVAQVFCFENRGEEIGVT
LPTRTARFTPIRI"
repeat_region 711624..711702
/gene="galTa"
/gene_synonym="galT'"
/locus_tag="Rv0618"
/note="79 bp imperfect direct repeat 2, 73/78 bp identical
to first copy at 709585..709663,
TAGGGTTCTGCGTTGTGACGGCGCCGACGCGGTGGACCCTGGCCGATGGCCGTGACCT
GCTGTTCTTTTCGCTGCCCGG"
gene <712174..712719
/gene="galTb"
/gene_synonym="'galT"
/locus_tag="Rv0619"
CDS <712174..712719
/codon_start=1
/transl_table=11
/gene="galTb"
/gene_synonym="'galT"
/locus_tag="Rv0619"
/product="Probable galactose-1-phosphate
uridylyltransferase GalTb [second part]"
/note="Rv0619, (MTCY19H5.02c), len: 181 aa (probable
partial CDS). Probable galTb, second part of
galactose-1-phosphate uridylyltransferase, highly similar
to C-terminal half of other galT proteins e.g.
P13212|GAL7_STRLI galactose-1-phosphate
uridylyltransferase from Streptomyces lividans (354 aa),
FASTA scores: opt: 416, E(): 5.2e-22, (43.0% identity in
186 aa overlap), etc. Cosmid sequence is correct but there
may be a frameshift mutation in this region which would
allow the two ORFS to be joined. Belongs to the
galactose-1-phosphate uridylyltransferase family 1. Note
that previously known as 'galT."
/db_xref="EnsemblGenomes-Gn:Rv0619"
/db_xref="EnsemblGenomes-Tr:CCP43360"
/db_xref="GOA:Q79FY3"
/db_xref="InterPro:IPR001937"
/db_xref="InterPro:IPR005850"
/db_xref="InterPro:IPR036265"
/db_xref="UniProtKB/TrEMBL:Q79FY3"
/protein_id="CCP43360.1"
/translation="GDRGDPAHPHGQIYAYPYLTPRTAAMLRQARRHRKRHGDNLFAS
LLAREVADGSRIVVRGELFTAFVPFAARWPVEVHIYPNRLVRNLTELNDGELDEFARI
YLDVLQRFDRMYSSPLPYMSALHQFSEVQRDGYFHVELMSIRRSATKLKYLAAAESAM
DAFIADVIPESVATRLRELGP"
gene 712716..713807
/gene="galK"
/locus_tag="Rv0620"
CDS 712716..713807
/codon_start=1
/transl_table=11
/gene="galK"
/locus_tag="Rv0620"
/product="Probable galactokinase GalK (galactose kinase)"
/note="Rv0620, (MTCY19H5.01c, MTCY20H10.01), len: 363 aa.
Probable galK, galactokinase, similar to others e.g.
P13227|GAL1_STRLI galactokinase from Streptomyces lividans
(397 aa); P06976|GAL1_ECOLI galactokinase from Escherichia
coli (381 aa), FASTA scores: opt: 669, E(): 0, (35.9%
identity in 365 aa overlap); etc. Contains PS00106
Galactokinase signature and PS00560 Serine
carboxypeptidases, histidine active site. Belongs to the
GHMP kinase family. GALK subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0620"
/db_xref="EnsemblGenomes-Tr:CCP43361"
/db_xref="GOA:P9WN63"
/db_xref="InterPro:IPR000705"
/db_xref="InterPro:IPR006204"
/db_xref="InterPro:IPR006206"
/db_xref="InterPro:IPR013750"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR019539"
/db_xref="InterPro:IPR019741"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR022963"
/db_xref="InterPro:IPR036554"
/db_xref="UniProtKB/Swiss-Prot:P9WN63"
/inference="protein motif:PROSITE:PS00106"
/inference="protein motif:PROSITE:PS00560"
/protein_id="CCP43361.1"
/translation="MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTG
AITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEI
GSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFG
APKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAAD
LGVSSLRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLL
TASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIALVPADRARDVAD
TVRRAAVTAGYDEPAVSRTYAAPGAAECR"
gene 714202..715266
/locus_tag="Rv0621"
CDS 714202..715266
/codon_start=1
/transl_table=11
/locus_tag="Rv0621"
/product="Possible membrane protein"
/note="Rv0621, (MTCY20H10.02), len: 354 aa. Possible
membrane protein; contains potential membrane spanning
regions. Also contains PS00017 ATP/GTP-binding site motif
A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0621"
/db_xref="EnsemblGenomes-Tr:CCP43362"
/db_xref="GOA:I6X9F4"
/db_xref="UniProtKB/TrEMBL:I6X9F4"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP43362.1"
/translation="MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFC
ERCGSPIGVVPWPSEESGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARN
DREEPSSARGAATTGVPFAQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGD
VESNSALEVTVADGRRDVAAGSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSG
APALAATRKGRSDRSAARGGSARTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYV
RVGIANRWVPQVSSKRVGLVAAGKTWTSADILRDHLALRQRFGGARLVWSGHWTTFSG
PDFWVTVVGPAQPTAAEANR"
gene 715370..716317
/locus_tag="Rv0622"
CDS 715370..716317
/codon_start=1
/transl_table=11
/locus_tag="Rv0622"
/product="Possible membrane protein"
/note="Rv0622, (MTCY20H10.03), len: 315 aa. Possible
membrane protein; contains potential membrane spanning
region. Shows weak similarity with Mycobacterium
tuberculosis hypothetical proteins Rv1804c, Rv1810, etc.
Start changed since first submission (-26 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0622"
/db_xref="EnsemblGenomes-Tr:CCP43363"
/db_xref="GOA:P96912"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/TrEMBL:P96912"
/protein_id="CCP43363.1"
/translation="MSFCVYCGAELADPTRCGACGAYKIGSTWHRTTTPTVGAATTAT
GWRPDPTGRHEGRYFVAGQPTDLVREGDAEAVDPLGQQQLDQSGAVGVSPSAVSGWVR
SGHRRLWWALAGVVAFLGLVGAGVVGTLFLNRDRESIDDKYLAALRRSGLTGEFNSDA
NAIARGKQVCRQLQDGGEQQGMPVDQVAVQYYCPQFSDGFHILETITVTGSFTLKDES
PNVYAPAITVSGSGCSGSAGYADIDRGTQVTVKNGQGDILATAFLQAGQGGRFLCTFP
FSFEITEGEDRYVVSVSRRGEMSYSFADLKANGLSLVLG"
gene 716410..716664
/gene="vapB30"
/locus_tag="Rv0623"
CDS 716410..716664
/codon_start=1
/transl_table=11
/gene="vapB30"
/locus_tag="Rv0623"
/product="Possible antitoxin VapB30"
/note="Rv0623, (MTCY20H10.04), len: 84 aa. Possible
vapB30,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0624,see Arcus et al. 2005. Also similar to others in
Mycobacterium tuberculosis e.g
MTCY28_2|Rv1740|MTCY28.02|MTCY04C12.25 conserved
hypothetical protein (70 aa), FASTA score: (73.5% identity
in 68 aa overlap); MTCY4C12_25|Rv0608|MTCY19H5.14c
conserved hypothetical protein (81 aa), FASTA score: (73.5
identity in 68 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0623"
/db_xref="EnsemblGenomes-Tr:CCP43364"
/db_xref="GOA:P9WJ35"
/db_xref="InterPro:IPR011660"
/db_xref="PDB:4XGQ"
/db_xref="PDB:4XGR"
/db_xref="UniProtKB/Swiss-Prot:P9WJ35"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43364.1"
/translation="MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRA
RVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDERGLPA"
gene 716664..717059
/gene="vapC30"
/locus_tag="Rv0624"
CDS 716664..717059
/codon_start=1
/transl_table=11
/gene="vapC30"
/locus_tag="Rv0624"
/product="Possible toxin VapC30. Contains PIN domain."
/note="Rv0624, (MTCY20H10.05), len: 131 aa. Possible
vapC30, toxin, part of toxin-antitoxin (TA) operon with
Rv0623, contains PIN domain, see Arcus et al. 2005. Highly
similar to others in Mycobacterium tuberculosis e.g.
Rv1741, Rv0609, Rv2759c,Rv0565c, Rv3854c, Rv3083, etc."
/db_xref="EnsemblGenomes-Gn:Rv0624"
/db_xref="EnsemblGenomes-Tr:CCP43365"
/db_xref="GOA:P9WF77"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="PDB:4XGQ"
/db_xref="PDB:4XGR"
/db_xref="UniProtKB/Swiss-Prot:P9WF77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43365.1"
/translation="MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALV
IEARFGEPGGRELDLWLHRAAVDLVAVHADQADAARAAYRTYGKGRHRAGLNYGDCFS
YGLAKISGQPLLFKGEDFQHTDIATVALP"
gene complement(717153..717893)
/locus_tag="Rv0625c"
CDS complement(717153..717893)
/codon_start=1
/transl_table=11
/locus_tag="Rv0625c"
/product="Probable conserved transmembrane protein"
/note="Rv0625c, (MTCY20H10.06c), len: 246 aa. Probable
conserved transmembrane protein, showing similarity with
others e.g. CAB61866.1|AL133252 putative integral membrane
protein from Streptomyces coelicolor (249 aa). Also
similar to Rv1491c|MTCY277_13 from Mycobacterium
tuberculosis. Contains potential membrane spanning
regions."
/db_xref="EnsemblGenomes-Gn:Rv0625c"
/db_xref="EnsemblGenomes-Tr:CCP43366"
/db_xref="GOA:P9WFS5"
/db_xref="InterPro:IPR015414"
/db_xref="InterPro:IPR032816"
/db_xref="UniProtKB/Swiss-Prot:P9WFS5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43366.1"
/translation="MSTHNDSAPTSRRRHIVRLVVFAGFLVGMFYLVAATDVIDVAAV
RGAVSATGPAAPLTYVVVSAVLGALFVPGPILAASSGLLFGPLVGVFVTLGATVGTAV
VASLVGRRAGRASARALLGGERADRTDALIERCGLWAVVGQRFVPGISDAFASYAFGT
FGVPLWQMAVGAFIGSAPRAFAYTALGAAIGDRSPLLASCAIAVWCVTAIIGAFAARH
GYRQWRAHARGDGADGGVEDPDREVGAR"
gene 718025..718285
/gene="vapB5"
/locus_tag="Rv0626"
CDS 718025..718285
/codon_start=1
/transl_table=11
/gene="vapB5"
/locus_tag="Rv0626"
/product="Possible antitoxin VapB5"
/note="Rv0626, (MTCY20H10.07), len: 86 aa. Possible
vapB5,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0627 (See Arcus et al., 2005; Pandey and Gerdes, 2005).,
similar to others in Mycobacterium tuberculosis
hypothetical proteins e.g. Rv0596c, Rv3385c,
Rv3407,Rv3181c, etc. Cofactor: Mg2+"
/db_xref="EnsemblGenomes-Gn:Rv0626"
/db_xref="EnsemblGenomes-Tr:CCP43367"
/db_xref="GOA:P9WF19"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="PDB:3DBO"
/db_xref="UniProtKB/Swiss-Prot:P9WF19"
/protein_id="CCP43367.1"
/translation="MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPR
RRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTEDLGPIR"
gene 718282..718689
/gene="vapC5"
/locus_tag="Rv0627"
CDS 718282..718689
/codon_start=1
/transl_table=11
/gene="vapC5"
/locus_tag="Rv0627"
/product="Possible toxin VapC5"
/note="Rv0627, (MTCY20H11.08), len: 135 aa. Possible
vapC5,toxin, part of toxin-antitoxin (TA) operon with
Rv0626,contains PIN domain (See Arcus et al., 2005; Pandey
and Gerdes, 2005). Similar to others in Mycobacterium
tuberculosis e.g. Rv0595c and Rv0665."
/db_xref="EnsemblGenomes-Gn:Rv0627"
/db_xref="EnsemblGenomes-Tr:CCP43368"
/db_xref="GOA:P96917"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="PDB:3DBO"
/db_xref="UniProtKB/Swiss-Prot:P96917"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43368.1"
/translation="MSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELR
VGVLAAATTDIRAQRLATLESVADMETLPVDDDAARMWARLRIHLAESGRRVRINDLW
IAAVAASRALPVITQDDDFAALDGAASVEIIRV"
gene complement(718761..719912)
/locus_tag="Rv0628c"
CDS complement(718761..719912)
/codon_start=1
/transl_table=11
/locus_tag="Rv0628c"
/product="Conserved hypothetical protein"
/note="Rv0628c, (MTCY20H10.09c), len: 383 aa. Conserved
hypothetical protein, highly similar to
Rv0874c|YZ02_MYCTU|Q10536 conserved hypothetical protein
from Mycobacterium tuberculosis (386 aa), FASTA scores:
opt: 2082, E(): 0, (81.5% identity in 383 aa overlap).
Also some similarity to P72543|SPU62616_1 hypothetical
protein from Synechococcus, FASTA scores: E(): 2.8e-28,
(36.6 identity in 265 aa overlap). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0628c"
/db_xref="EnsemblGenomes-Tr:CCP43369"
/db_xref="GOA:P9WKS7"
/db_xref="InterPro:IPR013702"
/db_xref="InterPro:IPR016741"
/db_xref="InterPro:IPR019494"
/db_xref="UniProtKB/Swiss-Prot:P9WKS7"
/protein_id="CCP43369.1"
/translation="MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSH
TDQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDF
VRTGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGR
RRGDTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGG
RPPLHRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGA
IGIGEVVEVGATVQFQVRDAAAADKDLRLAVERAAAELPGPPVGGLLFTCNGRGRRMF
GVTDHDASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD"
gene complement(720005..721732)
/gene="recD"
/locus_tag="Rv0629c"
CDS complement(720005..721732)
/codon_start=1
/transl_table=11
/gene="recD"
/locus_tag="Rv0629c"
/product="Probable exonuclease V (alpha chain) RecD
(exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease
V polypeptide)"
/note="Rv0629c, (MTCY20H10.10c), len: 575 aa. Probable
recD, exonuclease V, alpha chain (exodeoxyribonuclease
V,alpha chain) (see citation below), highly similar to
other exonucleases e.g. AF157643_3|AAD46809.1|recD
Escherichia coli RecD protein homolog from Mycobacterium
smegmatis (554 aa); P04993|EX5A_ECOLI|B2819
exodeoxyribonuclease V 67kd polypeptide (exonuclease V
alpha chain) from Escherichia coli strain K12 (608 aa),
FASTA scores: opt: 512, E(): 1.9e-24, (36.9% identity in
582 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop). Consists of three subunits;
RECB|Rv0630c, RECC|Rv0631c and RECD."
/db_xref="EnsemblGenomes-Gn:Rv0629c"
/db_xref="EnsemblGenomes-Tr:CCP43370"
/db_xref="GOA:P9WHJ1"
/db_xref="InterPro:IPR006344"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR027785"
/db_xref="UniProtKB/Swiss-Prot:P9WHJ1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43370.1"
/translation="MKLTDVDFAVEASGMVRAFNQAGVLDVSDVHVAQRLCALAGESD
ERVALAVAVAVRALRAGSVCVDLLSIARVAGHDDLPWPDPADWLAAVRASPLLADPPV
LHLYDDRLLYLDRYWREEEQVCADLLALLTSRRPAGVPDLRRLFPTGFDEQRRAAEIA
LSQGVTVLTGGPGTGKTTTVARLLALVAEQAELAGEPRPRIALAAPTGKAAARLAEAV
RREMAKLDATDRARLGDLHAVTLHRLLGAKPGARFRQDRQNRLPHNVIVVDETSMVSL
TLMARLAEAVRPGARLILVGDADQLASVEAGAVLADLVDGFSVRDDALVAQLRTSHRF
GKVIGTLAEAIRAGDGDAVLGLLRSGEERIEFVDDEDPAPRLRAVLVPHALRLREAAL
LGASDVALATLDEHRLLCAHRDGPTGVLHWNRRVQAWLAEETGQPPWTPWYAGRPLLV
TANDYGLRVYNGDTGVVLAGPTGLRAVISGASGPLDVATGRLGDVETMHAMTIHKSQG
SQVDEVTVLMPQEDSRLLTRELLYTAVTRAKRKVRVVGSEASVRAAIARRAVRASGLR
MRLQSTGCG"
gene complement(721729..725013)
/gene="recB"
/locus_tag="Rv0630c"
CDS complement(721729..725013)
/codon_start=1
/transl_table=11
/gene="recB"
/locus_tag="Rv0630c"
/product="Probable exonuclease V (beta chain) RecB
(exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V
polypeptide) (chi-specific endonuclease)"
/note="Rv0630c, (MTCY20H10.11c), len: 1094 aa. Probable
recB, exonuclease V, beta chain (exodeoxyribonuclease
V,beta chain) (see citation below), highly similar to
other exonucleases e.g. AF157643_2|recB|AAD46808.1
Escherichia coli RecB protein homolog from Mycobacterium
smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820
exodeoxyribonuclease V 135 kDa polypeptide (exonuclease V
beta chain) from Escherichia coli strain K12 (1180
aa),FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity
in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop). Belongs to the helicase family,
UVRD subfamily. Consists of three subunits; RECB,
RECC|Rv0631c and recd|Rv0629c."
/db_xref="EnsemblGenomes-Gn:Rv0630c"
/db_xref="EnsemblGenomes-Tr:CCP43371"
/db_xref="GOA:P9WMQ3"
/db_xref="InterPro:IPR000212"
/db_xref="InterPro:IPR004586"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR011604"
/db_xref="InterPro:IPR014016"
/db_xref="InterPro:IPR014017"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR034739"
/db_xref="InterPro:IPR038726"
/db_xref="UniProtKB/Swiss-Prot:P9WMQ3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43371.1"
/translation="MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAA
TLDEMLLITFNRAASRELRERVRGQIVEAVGALQGDAPPSGELVEHLLRGSDAERAQK
RSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADVELKESLTDLVTEIVDDRY
LANFGRQETDPELTYAEALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEEL
ERRKGRLRAQGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLE
RAFSRHSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQ
TVLRDATLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEA
LRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNALAEAGIPAI
YTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFGETAESLAAEGDALTDR
VAGTLREWADHARHRGVAAVFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAH
RERLGLPGLRDWLRRQAKAGAGPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFA
FNRNVRSDDILLYHDDGTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRA
QSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTPRVTDEQAWAVFAQWEAAGG
PSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSYSDLVRGSEAVTVTSEPA
AGGRADEVEIAVVAAPGSGADLTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELE
AQVRRHAPWWTVDVDHAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDF
EMPLAGGDLRGRSPDVSLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPLRGYLAG
SIDVVLRLPGQRYLVVDYKTNHLGDTAADYGFERLTEAMLHSDYPLQALLYVVVLHRF
LRWRQRDYAPARHLGGVLYLFVRGMCGAATPVTAGHPAGVFTWNPPTALVVALSDLLD
RGRLQS"
gene complement(725013..728306)
/gene="recC"
/locus_tag="Rv0631c"
CDS complement(725013..728306)
/codon_start=1
/transl_table=11
/gene="recC"
/locus_tag="Rv0631c"
/product="Probable exonuclease V (gamma chain) RecC
(exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease
V polypeptide)"
/note="Rv0631c, (MTCY20H10.12c), len: 1097 aa. Probable
recC, exonuclease V, gamma chain (exodeoxyribonuclease
V,gamma chain) (see Mizrahi & Andersen 1998), highly
similar to other exonucleases e.g.
AF157643_1|RecC|AAD46807.1 Escherichia coli RecC protein
homolog from Mycobacterium smegmatis (1085 aa);
P07648|EX5C_ECOLI|B2822 exodeoxyribonuclease V 125 kDa
polypeptide (exonuclease V gamma chain) from Escherichia
coli strain K12 (1122 aa),FASTA scores: opt: 954, E(): 0,
(29.2% identity in 1109 aa overlap); etc. Consists of
three subunits; RECB|Rv0630c,RECC and recd|Rv0629c. The
transcription of this CDS seems to be activated
specifically in host granulomas (see Ramakrishnan et al.,
2000)."
/db_xref="EnsemblGenomes-Gn:Rv0631c"
/db_xref="EnsemblGenomes-Tr:CCP43372"
/db_xref="GOA:P9WIQ5"
/db_xref="InterPro:IPR006697"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR013986"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041500"
/db_xref="UniProtKB/Swiss-Prot:P9WIQ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43372.1"
/translation="MALHLHRAERTDLLADGLGALLADPQPDPFAQELVLVAARGVER
WLSQRLSLVLGCGPGRADGVCAGIAFRNPQSLIAEITGTLDDDPWSPEALAWPLLAVI
DASLDEPWCRTLASHLGHFATTDAEAELRRGRRYSVARRLAGLFASYARQRPGLLAAW
LDGDLGELPGDLAWQPPLWRALVTTVGADPPHVRHDKTIARLRDGPADLPARLSLFGH
TRLACTDVQLLDALAVHHDLHLWLPHPSDELWRALAGFQGADGLLPRRQDTSRRAAQH
PLLETLGRDVRELQRALPAARATDEFLGATTKPDTLLGWLQADIAGNAPRPAGRSLSD
ADRSVQVHACHGPARQIDVLREVLLGLLEDDPTLQPRDIVVMCPDIDTYAPLIVAGFG
LGEVAGDCHPAHRLRVRLADRALTQTNPLLSVAAELLTIAETRATASQLLNLAQAAPV
RAKFGFADDDLDTITTWVRESNIRWGFDPTHRRRYGLDTVVHNTWRFGLDRILTGVAM
SEDSQAWLDTALPLDDVGSNRVELAGRLAEFVERLHHVVGGLSGARPLVAWLDALATG
IDLLTACNDGWQRAQVQREFADVLARAGSRAAPLLRLPDVRALLDAQLAGRPTRANFR
TGTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRLSHPDGDDVLAREPMTGERDIRSEDR
QLLLDAIGAATQTLVITYTGADERTGQPRPPAVPLAELLDALDQTTSAPVRERILVTH
PLQPFDRKNVTPGALLGAKPFTFDPAALAAAQAAAGKRCPPTAFISGRLPAPPAADVT
LADLLDFFKDPVKGFFRALDYTLPWDVDTVEDSIPVQVDALAEWTVGERMLRDMLRGL
HPDDAAHSEWRRGTLPPGRLGVRRAKEIRNRARDLAAAALAHRDGHGQAHDVDVDLGD
GRRLSGTVTPVFGGRTVSVTYSKLAPKHVLPAWIGLVTLAAQEPGREWSALCIGRSKT
RNHIARRLFVPPPDPVAVLRELVLLYDAGRREPLPLPLKTSCAWAQARRDGQDPYPPA
RECWQTNRFRPGDDDAPAHVRAWGPRAPFEVLLGKPRAGEEVAGEETRLGALAARLWL
PLLAAEGSV"
gene complement(728583..729278)
/gene="echA3"
/locus_tag="Rv0632c"
CDS complement(728583..729278)
/codon_start=1
/transl_table=11
/gene="echA3"
/locus_tag="Rv0632c"
/product="Probable enoyl-CoA hydratase EchA3 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv0632c, (MTCY20H10.13c), len: 231 aa. Probable
echA3, enoyl-CoA hydratase, almost identical to the
MTU88877_1 enoyl-CoA hydratase of Mycobacterium
tuberculosis field isolate NTI64719, FASTA score: (92.4%
identity in 184 aa overlap). Also similar to others e.g.
P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter
capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA
scores: opt: 206, E(): 6.3e-07, (31.5% identity in 232 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0632c"
/db_xref="EnsemblGenomes-Tr:CCP43373"
/db_xref="GOA:I6Y8B5"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:I6Y8B5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43373.1"
/translation="MSDPVSYTRKDSIAVISMDDGKVNALGPAMQQALNAAIDNADRD
DVGALVITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLLSYPKPVVMACTG
HAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYAALEIMKLRLTRSAYQQATGL
AKTFFGETALAAGFIDEIALPEVVVSRAEEAAREFAGLNQHAHAATKLRSRADALTAI
RAGIDGIAAEFGL"
gene complement(729327..730166)
/locus_tag="Rv0633c"
CDS complement(729327..730166)
/codon_start=1
/transl_table=11
/locus_tag="Rv0633c"
/product="Possible exported protein"
/note="Rv0633c, (MTCY20H11.14c), len: 279 aa. Possible
exported protein; has hydrophobic stretch at aa 23-41."
/db_xref="EnsemblGenomes-Gn:Rv0633c"
/db_xref="EnsemblGenomes-Tr:CCP43374"
/db_xref="GOA:P96923"
/db_xref="UniProtKB/TrEMBL:P96923"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43374.1"
/translation="MVDSMGWVLSSWHEVTGVDSGTWLAWAAWAALGLGVVALVVTKR
QIQRNRRLAAEQTRPYVAMFMEPHVADWHVIELVVRNFGRTAAYDVRFSFPNPPTVAQ
YENAANGYADVVELRLPQELPMLAPGQEWRMVWDSALDRAEIGRGIESRFPGTVTYYD
RPEQPRRWRFWRRGRRPLETKVVLDWDALPPVARIELMTTHDLAKREKQKLELLRSLL
TYFHYASKETRPDVFRSEIDRINRAAAETQDRWRARQVEVPTEVSQRSEGQGPQPTRI
PAG"
gene complement(730320..731033)
/locus_tag="Rv0634c"
CDS complement(730320..731033)
/codon_start=1
/transl_table=11
/locus_tag="Rv0634c"
/product="Possible glyoxalase II (hydroxyacylglutathione
hydrolase) (GLX II)"
/note="Rv0634c, (MTCY20H10.15c), len: 237 aa. Possible
glyoxalase II, equivalent to NP_302290.1|NC_002677
putative glyoxylase II from Mycobacterium leprae (238 aa);
and similar to U00011_3|Y0BK_MYCLE|Q49649 hypothetical
23.9 kDa protein from Mycobacterium leprae (218 aa), FASTA
scores: opt: 281, E(): 3.9e-12, (31.8% identity in 201 aa
overlap). Also similar to other glyoxalases and
metallo-beta-lactamase family proteins e.g.
NP_386770.1|NC_003047 putative hydroxyacylglutathione
hydrolase from Sinorhizobium meliloti (256 aa); etc. Also
similar to other putative glyoxylases from Mycobacterium
tuberculosis e.g. Rv1637c. Belongs to the glyoxalase II
family. Cofactor: binds two zinc ions."
/db_xref="EnsemblGenomes-Gn:Rv0634c"
/db_xref="EnsemblGenomes-Tr:CCP43375"
/db_xref="GOA:I6Y4A5"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:I6Y4A5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43375.1"
/translation="MSKDRLYFRQLLSGRDFAVGDMFATQMRNFAYLIGDRTTGDCVV
VDPAYAAGDLLDALESDDMQLSGVLVTHHHPDHVGGSMMGFQLPGLAELLERASVPVH
VNTHEALWVSRVTGIPVGDLITHEHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGRLV
AGDTLFLEGCGRTDFPGGDSDEMYRSLRQLAELPGDPTVFPGHWYSAEPSASLSEVKR
SNYVYRPASLDQWRMLMGG"
gene 731113..731364
/locus_tag="Rv0634A"
CDS 731113..731364
/codon_start=1
/transl_table=11
/locus_tag="Rv0634A"
/product="Unknown protein"
/note="Rv0634A, len: 83 aa. Unknown protein. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0634A"
/db_xref="EnsemblGenomes-Tr:CCP43376"
/db_xref="InterPro:IPR019239"
/db_xref="UniProtKB/Swiss-Prot:P9WKS5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43376.1"
/translation="MGSDCGCGGYLWSMLKRVEIEVDDDLIQKVIRRYRVKGAREAVN
LALRTLLGEADTAEHGHDDEYDEFSDPNAWVPRRSRDTG"
gene 731494..731566
/gene="thrT"
tRNA 731494..731566
/gene="thrT"
/product="tRNA-Thr"
/anticodon=(pos:731527..731529,aa:Thr,seq:ggt)
/note="codon recognized: ACC; thrT, tRNA-Thr, anticodon
ggt, length = 73"
gene 731603..731676
/gene="metT"
tRNA 731603..731676
/gene="metT"
/product="tRNA-Met"
/anticodon=(pos:731637..731639,aa:Met,seq:cat)
/note="codon recognized: AUG; metT, tRNA-Met, anticodon
cat, length = 74"
gene 731712..731879
/gene="rpmG2"
/locus_tag="Rv0634B"
CDS 731712..731879
/codon_start=1
/transl_table=11
/gene="rpmG2"
/locus_tag="Rv0634B"
/product="50S ribosomal protein L33 RpmG2"
/note="Rv0634B, len: 55 aa. rpmG2, 50S ribosomal protein
L33. Note that Mycobacterium tuberculosis has a second
rpmG gene: P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1
putative 50S ribosomal protein L33 (55 aa), FASTA scores:
opt: 391,E(): 2.9e-25, (100.0% identity in 55 aa overlap).
Belongs to the L33P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0634B"
/db_xref="EnsemblGenomes-Tr:CCP43377"
/db_xref="GOA:P9WH95"
/db_xref="InterPro:IPR001705"
/db_xref="InterPro:IPR011332"
/db_xref="InterPro:IPR018264"
/db_xref="InterPro:IPR038584"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH95"
/protein_id="CCP43377.1"
/translation="MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLELKKFCPN
CGKHQAHRETR"
gene 731930..732406
/gene="hadA"
/locus_tag="Rv0635"
CDS 731930..732406
/codon_start=1
/transl_table=11
/gene="hadA"
/locus_tag="Rv0635"
/product="(3R)-hydroxyacyl-ACP dehydratase subunit HadA"
/note="Rv0635, (MTCY20H10.16), len: 158 aa.
HadA,(3R)-hydroxyacyl-ACP dehydratase subunit, equivalent
to NP_302287.1|NC_002677 conserved hypothetical protein
from Mycobacterium leprae (159 aa); and highly similar to
YV31_MYCLE|P54879 conserved hypothetical protein from
Mycobacterium leprae (166 aa), FASTA scores: opt: 387,
E(): 5.9e-21, (43.4% identity in 145 aa overlap). Also
similar CAB77410.1|AL160431|SCD82.07 hypothetical protein
from Streptomyces coelicolor (150 aa). And highly similar
to two hypothetical proteins from Mycobacterium
tuberculosis: Rv0504c|YV31_MYCTU|Q11168 (166 aa), FASTA
scores: opt: 405,E(): 3.2e-22, (45.0% identity in 140 aa
overlap); and Rv0637|MTY20H10_19 (2 ORFs downstream) (166
aa), FASTA score: (48.7% identity in 150 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0635"
/db_xref="EnsemblGenomes-Tr:CCP43378"
/db_xref="GOA:P9WFK1"
/db_xref="InterPro:IPR016709"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR039569"
/db_xref="PDB:4RLJ"
/db_xref="PDB:4RLT"
/db_xref="PDB:4RLU"
/db_xref="PDB:4RLW"
/db_xref="UniProtKB/Swiss-Prot:P9WFK1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43378.1"
/translation="MALSADIVGMHYRYPDHYEVEREKIREYAVAVQNDDAWYFEEDG
AAELGYKGLLAPLTFICVFGYKAQAAFFKHANIATAEAQIVQVDQVLKFEKPIVAGDK
LYCDVYVDSVREAHGTQIIVTKNIVTNEEGDLVQETYTTLAGRAGEDGEGFSDGAA"
gene 732393..732821
/gene="hadB"
/locus_tag="Rv0636"
CDS 732393..732821
/codon_start=1
/transl_table=11
/gene="hadB"
/locus_tag="Rv0636"
/product="(3R)-hydroxyacyl-ACP dehydratase subunit HadB"
/note="Rv0636, (MTCY20H10.17), len: 142 aa.
HadB,(3R)-hydroxyacyl-ACP dehydratase subunit, equivalent
to NP_302286.1|NC_002677 conserved hypothetical protein
from Mycobacterium leprae (142 aa). Shows structural
similarity to six others in Mycobacterium tuberculosis
(see Castell et al (2005) below). Also highly similar to
CAB77411.1|AL160431|SCD82.08 hypothetical protein from
Streptomyces coelicolor (142 aa); and similar to others
e.g. U28943|CELE04F6_3 from Caenorhabditis elegans (cosmid
E04) (298 aa), FASTA scores: opt: 167, E(): 0.00064, (31.6
identity in 117 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0636"
/db_xref="EnsemblGenomes-Tr:CCP43379"
/db_xref="InterPro:IPR002539"
/db_xref="InterPro:IPR029069"
/db_xref="PDB:4RLJ"
/db_xref="PDB:4RLT"
/db_xref="PDB:4RLU"
/db_xref="PDB:4RLW"
/db_xref="UniProtKB/TrEMBL:I6WYY7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43379.1"
/translation="MALREFSSVKVGDQLPEKTYPLTRQDLVNYAGVSGDLNPIHWDD
EIAKVVGLDTAIAHGMLTMGIGGGYVTSWVGDPGAVTEYNVRFTAVVPVPNDGKGAEL
VFNGRVKSVDPESKSVTIALTATTGGKKIFGRAIASAKLA"
gene 732825..733325
/gene="hadC"
/locus_tag="Rv0637"
CDS 732825..733325
/codon_start=1
/transl_table=11
/gene="hadC"
/locus_tag="Rv0637"
/product="(3R)-hydroxyacyl-ACP dehydratase subunit HadC"
/note="Rv0637, (MTCY20H10.18), len: 166 aa.
HadC,(3R)-hydroxyacyl-ACP dehydratase subunit, equivalent
to NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved
hypothetical protein from Mycobacterium leprae (166
aa),FASTA scores: opt: 352, E(): 4e-19, (39.2% identity in
148 aa overlap); and highly similar to others from
Mycobacterium leprae e.g. NP_302287.1|NC_002677 conserved
hypothetical protein (159 aa). Also highly similar to
CAB77410.1|AL160431|SCD82.07 hypothetical protein from
Streptomyces coelicolor (150 aa);
Rv0635|NP_215149.1|NC_000962|MTY20H10_17 conserved
hypothetical protein (two ORFs upstream) from
Mycobacterium tuberculosis (158 aa), FASTA score: (49.3%
identity in 150 aa overlap); and
Rv0504c|NP_215018.1|NC_000962|YV31_MYCTU|Q11168
hypothetical protein from Mycobacterium tuberculosis (166
aa), FASTA scores: opt: 380, E(): 3.8e-21, (43.1% identity
in 137 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0637"
/db_xref="EnsemblGenomes-Tr:CCP43380"
/db_xref="GOA:P9WFJ9"
/db_xref="InterPro:IPR016709"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR039569"
/db_xref="PDB:5ZY8"
/db_xref="UniProtKB/Swiss-Prot:P9WFJ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43380.1"
/translation="MALKTDIRGMIWRYPDYFIVGREQCREFARAVKCDHPAFFSEEA
AADLGYDALVAPLTFVTILAKYVQLDFFRHVDVGMETMQIVQVDQRFVFHKPVLAGDK
LWARMDIHSVDERFGADIVVTRNLCTNDDGELVMEAYTTLMGQQGDGSARLKWDKESG
QVIRTA"
gene 733524..733596
/gene="trpT"
tRNA 733524..733596
/gene="trpT"
/product="tRNA-Trp"
/anticodon=(pos:733557..733559,aa:Trp,seq:cca)
/note="codon recognized: UGG; trpT, tRNA-Trp, anticodon
cca, length = 73"
gene 733737..734222
/gene="secE1"
/gene_synonym="secE"
/locus_tag="Rv0638"
CDS 733737..734222
/codon_start=1
/transl_table=11
/gene="secE1"
/gene_synonym="secE"
/locus_tag="Rv0638"
/product="Probable preprotein translocase SecE1"
/note="Rv0638, (MTCY20H10.19), len: 161 aa. Probable
secE1,preprotein translocase (tail-anchored membrane
protein) (see citation below), highly similar at
C-terminal half to others e.g. P36690|SECE_STRGR
preprotein translocase SECE subunit from Streptomyces
griseus (86 aa), FASTA scores: opt: 220, E(): 4.6e-06,
(35.4% identity in 96 aa overlap); P16920|SECE_ECOLI
preprotein translocase sece subunit from Escherichia coli
strains K12 and O157:H7 (127 aa), FASTA scores: opt: 122,
E(): 0.34, (37.0% identity in 54 aa overlap); etc.
Contains PS01067 Protein secE/sec61-gamma signature.
Belongs to the SECE/SEC61-gamma family. Part of the
prokaryotic protein translocation apparatus which comprise
SECA|Rv3240c, SECD|Rv2587c, SECE, SECF|Rv2586c,SECG|Rv1440
and SECY|Rv0732. Note that previously known as secE."
/db_xref="EnsemblGenomes-Gn:Rv0638"
/db_xref="EnsemblGenomes-Tr:CCP43381"
/db_xref="GOA:P9WGN7"
/db_xref="InterPro:IPR001901"
/db_xref="InterPro:IPR005807"
/db_xref="InterPro:IPR038379"
/db_xref="UniProtKB/Swiss-Prot:P9WGN7"
/inference="protein motif:PROSITE:PS01067"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43381.1"
/translation="MSDEGDVADEAVADGAENADSRGSGGRTALVTKPVVRPQRPTGK
RSRSRAAGADADVDVEEPSTAASEATGVAKDDSTTKAVSKAARAKKASKPKARSVNPI
AFVYNYLKQVVAEMRKVIWPNRKQMLTYTSVVLAFLAFMVALVAGADLGLTKLVMLVF
G"
gene 734254..734970
/gene="nusG"
/locus_tag="Rv0639"
CDS 734254..734970
/codon_start=1
/transl_table=11
/gene="nusG"
/locus_tag="Rv0639"
/product="Probable transcription antitermination protein
NusG"
/note="Rv0639, (MTCY20H10.20), len: 238 aa. Probable
nusG,transcription antitermination protein, equivalent to
NP_302283.1|NC_002677 transcription antitermination
protein nusG from Mycobacterium leprae (228 aa). Also
highly similar to others e.g. P36260|NUSG_STRGR from
Streptomyces griseus (294 aa), FASTA scores: opt: 845,
E(): 0, (55.4% identity in 233 aa overlap); etc. Note that
shorter at the N-terminus than other nusG. Contains
PS01014 Transcription termination factor nusG signature.
Belongs to the NusG family."
/db_xref="EnsemblGenomes-Gn:Rv0639"
/db_xref="EnsemblGenomes-Tr:CCP43382"
/db_xref="GOA:P9WIU9"
/db_xref="InterPro:IPR001062"
/db_xref="InterPro:IPR006645"
/db_xref="InterPro:IPR008991"
/db_xref="InterPro:IPR014722"
/db_xref="InterPro:IPR015869"
/db_xref="InterPro:IPR036735"
/db_xref="PDB:2MI6"
/db_xref="UniProtKB/Swiss-Prot:P9WIU9"
/inference="protein motif:PROSITE:PS01014"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43382.1"
/translation="MTTFDGDTSAGEAVDLTEANAFQDAAAPAEEVDPAAALKAELRS
KPGDWYVVHSYAGYENKVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNR
KVLPGYILVRMDLTDDSWAAVRNTPGVTGFVGATSRPSALALDDVVKFLLPRGSTRKA
AKGAASTAAAAEAGGLERPVVEVDYEVGESVTVMDGPFATLPATISEVNAEQQKLKVL
VSIFGRETPVELTFGQVSKI"
gene 735022..735450
/gene="rplK"
/locus_tag="Rv0640"
CDS 735022..735450
/codon_start=1
/transl_table=11
/gene="rplK"
/locus_tag="Rv0640"
/product="50S ribosomal protein L11 RplK"
/note="Rv0640, (MTCY20H11.21), len: 142 aa. rplK, 50S
ribosomal protein L11, equivalent to NP_302282.1|NC_002677
50S ribosomal protein L11 from Mycobacterium leprae (142
aa). Also highly similar to others e.g.
P48954|RL11_STRCO|SCD82.19 50s ribosomal protein L11 from
Streptomyces coelicolor (144 aa), FASTA scores: opt:
763,E(): 0, (84.6% identity in 143 aa overlap); etc.
Contains PS00359 Ribosomal protein L11 signature. Belongs
to the L11P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0640"
/db_xref="EnsemblGenomes-Tr:CCP43383"
/db_xref="GOA:P9WHE5"
/db_xref="InterPro:IPR000911"
/db_xref="InterPro:IPR006519"
/db_xref="InterPro:IPR020783"
/db_xref="InterPro:IPR020784"
/db_xref="InterPro:IPR020785"
/db_xref="InterPro:IPR036769"
/db_xref="InterPro:IPR036796"
/db_xref="UniProtKB/Swiss-Prot:P9WHE5"
/inference="protein motif:PROSITE:PS00359"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43383.1"
/translation="MAPKKKVAGLIKLQIVAGQANPAPPVGPALGQHGVNIMEFCKAY
NAATENQRGNVIPVEITVYEDRSFTFTLKTPPAAKLLLKAAGVAKGSAEPHKTKVAKV
TWDQVREIAETKKTDLNANDVDAAAKIIAGTARSMGITVE"
gene 735517..736224
/gene="rplA"
/locus_tag="Rv0641"
CDS 735517..736224
/codon_start=1
/transl_table=11
/gene="rplA"
/locus_tag="Rv0641"
/product="50S ribosomal protein L1 RplA"
/note="Rv0641, (MTCY20H10.22), len: 235 aa. rplA, 50S
ribosomal protein L1, equivalent to NP_302281.1|NC_002677
50S ribosomal protein L1 from Mycobacterium leprae (235
aa). Also highly similar to others e.g. P3625|RL1_STRGR
50s ribosomal protein L1 from Streptomyces griseus (240
aa),FASTA scores: opt: 1081, E(): 0, (72.2% identity in
230 aa overlap); etc. Belongs to the L1P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0641"
/db_xref="EnsemblGenomes-Tr:CCP43384"
/db_xref="GOA:P9WHC7"
/db_xref="InterPro:IPR002143"
/db_xref="InterPro:IPR005878"
/db_xref="InterPro:IPR016095"
/db_xref="InterPro:IPR023673"
/db_xref="InterPro:IPR023674"
/db_xref="InterPro:IPR028364"
/db_xref="UniProtKB/Swiss-Prot:P9WHC7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43384.1"
/translation="MSKTSKAYRAAAAKVDRTNLYTPLQAAKLAKETSSTKQDATVEV
AIRLGVDPRKADQMVRGTVNLPHGTGKTARVAVFAVGEKADAAVAAGADVVGSDDLIE
RIQGGWLEFDAAIATPDQMAKVGRIARVLGPRGLMPNPKTGTVTADVAKAVADIKGGK
INFRVDKQANLHFVIGKASFDEKLLAENYGAAIDEVLRLKPSSSKGRYLKKITVSTTT
GPGIPVDPSITRNFAGE"
gene complement(736298..737203)
/gene="mmaA4"
/locus_tag="Rv0642c"
CDS complement(736298..737203)
/codon_start=1
/transl_table=11
/gene="mmaA4"
/locus_tag="Rv0642c"
/product="Methoxy mycolic acid synthase 4 MmaA4 (methyl
mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid
synthase)"
/note="Rv0642c, (MTCY20H10.23c), len: 301 aa.
MmaA4,methoxy mycolic acid synthase 4 (methyltransferase)
(see citations below). Equivalent to
AAC44876|AAC44876.1|cmaA methyl transferase (mycolic acid
modification protein) from Mycobacterium bovis BCG strain
Pasteur (298 aa); NP_302280.1|NC_002677 methyl mycolic
acid synthase 4 from Mycobacterium leprae (298 aa); and
highly similar to others from Mycobacteria e.g. downstream
ORF P72027|mmaA3|Rv0643c|MTCY20H10.24c putative methoxy
mycolic acid synthase 3 from Mycobacterium tuberculosis
(293 aa). Phosphorylated in vitro by PknJ|Rv2088 (See Jang
et al.,2010)."
/db_xref="EnsemblGenomes-Gn:Rv0642c"
/db_xref="EnsemblGenomes-Tr:CCP43385"
/db_xref="GOA:Q79FX8"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:2FK7"
/db_xref="PDB:2FK8"
/db_xref="PDB:3HA3"
/db_xref="PDB:3HA5"
/db_xref="PDB:3HA7"
/db_xref="UniProtKB/Swiss-Prot:Q79FX8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43385.1"
/translation="MTRMAEKPISPTKTRTRFEDIQAHYDVSDDFFALFQDPTRTYSC
AYFEPPELTLEEAQYAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRRAVERFDVNVIGL
TLSKNQHARCEQVLASIDTNRSRQVLLQGWEDFAEPVDRIVSIEAFEHFGHENYDDFF
KRCFNIMPADGRMTVQSSVSYHPYEMAARGKKLSFETARFIKFIVTEIFPGGRLPSTE
MMVEHGEKAGFTVPEPLSLRPHYIKTLRIWGDTLQSNKDKAIEVTSEEVYNRYMKYLR
GCEHYFTDEMLDCSLVTYLKPGAAA"
gene complement(737268..738149)
/gene="mmaA3"
/locus_tag="Rv0643c"
CDS complement(737268..738149)
/codon_start=1
/transl_table=11
/gene="mmaA3"
/locus_tag="Rv0643c"
/product="Methoxy mycolic acid synthase 3 MmaA3 (methyl
mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid
synthase)"
/note="Rv0643c, (MTCY20H10.24c), len: 293 aa.
MmaA3,methoxy mycolic acid synthase 3 (methyltransferase)
(see citations below). Equivalent to
AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid
modification protein) from Mycobacterium bovis BCG strain
Pasteur (289 aa); and highly similar to others from
Mycobacteria e.g. upstream ORF
P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy
mycolic acid synthase 4 from Mycobacterium tuberculosis
(301 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0643c"
/db_xref="EnsemblGenomes-Tr:CCP43386"
/db_xref="GOA:P0CH91"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P0CH91"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43386.1"
/translation="MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYF
ERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLS
KNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFA
YNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIE
EHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCA
KAFRMGYIDCNQFTLAK"
gene complement(738297..739160)
/gene="mmaA2"
/locus_tag="Rv0644c"
CDS complement(738297..739160)
/codon_start=1
/transl_table=11
/gene="mmaA2"
/locus_tag="Rv0644c"
/product="Methoxy mycolic acid synthase 2 MmaA2 (methyl
mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid
synthase)"
/note="Rv0644c, (MTCY20H10.25c), len: 287 aa.
MmaA2,methoxy mycolic acid synthase 2 (methyltransferase)
(see citations below). Equivalent to
AAC44874|AAC44874.1|cmaC methyl transferase (mycolic acid
modification protein) from Mycobacterium bovis BCG strain
Pasteur (287 aa); and highly similar to others from
Mycobacteria e.g. upstream ORF
P72028|mmaA4|Rv0642c|MTCY20H10.23c putative methoxy
mycolic acid synthase 4 from Mycobacterium tuberculosis
(301 aa). Note that alternative start is at position
739247."
/db_xref="EnsemblGenomes-Gn:Rv0644c"
/db_xref="EnsemblGenomes-Tr:CCP43387"
/db_xref="GOA:Q79FX6"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:1TPY"
/db_xref="UniProtKB/Swiss-Prot:Q79FX6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43387.1"
/translation="MVNDLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMT
LEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAAH
VQKSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPP
DGVLLLHTITGLTRQQMVDHGLPLTLWLARFLKFIATEIFPGGQPPTIEMVEEQSAKT
GFTLTRRQSLQPHYARTLDLWAEALQEHKSEAIAIQSEEVYERYMKYLTGCAKLFRVG
YIDVNQFTLAK"
gene complement(739327..740187)
/gene="mmaA1"
/locus_tag="Rv0645c"
CDS complement(739327..740187)
/codon_start=1
/transl_table=11
/gene="mmaA1"
/locus_tag="Rv0645c"
/product="Methoxy mycolic acid synthase 1 MmaA1 (methyl
mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid
synthase)"
/note="Rv0645c, (MTCY20H10.26c), len: 286 aa.
MmaA1,methoxy mycolic acid synthase 1 (methyltransferase)
(see citations below). Equivalent to NP_302279.1|NC_002677
methyl mycolic acid synthase 1 from Mycobacterium leprae
(286 aa); and highly similar to others from Mycobacteria
e.g. upstream ORF P72028|mmaA4|Rv0642c|MTCY20H10.23c
putative methoxy mycolic acid synthase 4 from
Mycobacterium tuberculosis (301 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0645c"
/db_xref="EnsemblGenomes-Tr:CCP43388"
/db_xref="GOA:P9WPB1"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WPB1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43388.1"
/translation="MAKLRPYYEESQSAYDISDDFFALFLDPTWVYTCAYFERDDMTL
EEAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGLTLSRNHYERS
KDRLAAIGTQRRAEARLQGWEEFEENVDRIVSFEAFDAFKKERYLTFFERSYDILPDD
GRMLLHSLFTYDRRWLHEQGIALTMSDLRFLKFLRESIFPGGELPSEPDIVDNAQAAG
FTIEHVQLLQQHYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGL
INVAQFTMTK"
gene complement(740234..741139)
/gene="lipG"
/locus_tag="Rv0646c"
CDS complement(740234..741139)
/codon_start=1
/transl_table=11
/gene="lipG"
/locus_tag="Rv0646c"
/product="Probable lipase/esterase LipG"
/note="Rv0646c, (MTCY20H10.27c), len: 301 aa. Probable
lipG, lipase/esterase, equivalent to NP_302278.1|NC_002677
probable hydrolase from Mycobacterium leprae (304 aa).
Also highly similar to various hydrolases, especially
lipases e.g. AA61351.1|X88895 carboxyl esterase from
Acinetobacter calcoaceticus (312 aa), FASTA scores: opt:
867, E(): 0,(50.2% identity in 279 aa overlap); etc. Also
similar to transferases e.g. P77026 macrolide
2'-phosphotransferase II from Escherichia coli (279 aa),
FASTA scores: E(): 1.3e-14,(32.5% identity in 286 aa
overlap). Similar to M. tuberculosis non-heme
bromoperoxidases and epoxide hydrolases."
/db_xref="EnsemblGenomes-Gn:Rv0646c"
/db_xref="EnsemblGenomes-Tr:CCP43389"
/db_xref="GOA:P96935"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P96935"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43389.1"
/translation="MDIRSGTAVSGDVKLYYEDMGDLDHPPVLLIMGLGAQMLLWRTD
FCARLVAKGLRVIRYDNRDVGLSTKTERHRPGQPLATRLVRSWLGLPSQAAYTLEDMA
ADAAALLDHLDVKHAHVVGASMGGMIAQIFAARFAQRTKTLAVIFSSNNHRFLPPPAP
RALLALLTGPPPDSPRDVIVDNAVRVSKIIGSPAYPIPEDQVRAEAAESYDRNFHPWG
IAQQFSAILGSGSLLRYDRRIVAPTVVIHGRADKLMRPFGGRAVARAINGARLVLIDG
MGHDLPRQLWDRVIGELTRNFSEAG"
gene complement(741151..742617)
/locus_tag="Rv0647c"
CDS complement(741151..742617)
/codon_start=1
/transl_table=11
/locus_tag="Rv0647c"
/product="Conserved protein"
/note="Rv0647c, (MTCY20H10.28c), len: 488 aa. Conserved
protein, equivalent to NP_302277.1|NC_002677 conserved
hypothetical protein from Mycobacterium leprae (448 aa).
Also showing similarity to a variety of hypothetical
ABC1-like proteins or conserved hypothetical proteins e.g.
D90908_28|P73627 ABC1-like protein from Synechocystis (585
aa), FASTA scores: E(): 1.8e-31, (29.1% identity in 474 aa
overlap); Q55884 HYPOTHETICAL6 5.0 KD protein (567
aa),FASTA scores: opt: 583, E(): 5.7e-30, (28.1% identity
in 416 aa overlap); etc. Also similar to Rv3197 conserved
hypothetical protein from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0647c"
/db_xref="EnsemblGenomes-Tr:CCP43390"
/db_xref="GOA:P9WQI1"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR004147"
/db_xref="InterPro:IPR011009"
/db_xref="UniProtKB/Swiss-Prot:P9WQI1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43390.1"
/translation="MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGST
THREVAKLDRVPLPVEAARVAATGWQVTRTAVRFIGRLPRKGPWQQKVIKELPQTFAD
LGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLF
ASFEEEPFASASIAQVHYATLRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAK
LGRRLSAQDVVADFADNLAEELDFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTT
ERVLTMERVHGIRIDNAAAIRKAGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLY
VDEAGRIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPE
TQAAKDLERFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVER
YMKLLAPRWQMMSDPQLTGYFANFMVEVSREHQSDIEV"
gene 742719..746366
/locus_tag="Rv0648"
CDS 742719..746366
/codon_start=1
/transl_table=11
/locus_tag="Rv0648"
/product="Alpha-mannosidase"
/note="Rv0648, (MTCY20H10.29), len: 1215 aa.
Alpha-mannosidase (see citation below), showing some
similarity to hypothetical proteins and various sugar
hydrolases e.g. SYCSLRA_6|Q55528 hypothetical 1 20.4 kDa
protein from Synechocystis (1042 aa), FASTA scores: opt:
260, E(): 3.6e-08, (23.4% identity in 602 aa overlap);
etc. Contains PS00659 Glycosyl hydrolases family 5
signature."
/db_xref="EnsemblGenomes-Gn:Rv0648"
/db_xref="EnsemblGenomes-Tr:CCP43391"
/db_xref="GOA:P96937"
/db_xref="InterPro:IPR000602"
/db_xref="InterPro:IPR011013"
/db_xref="InterPro:IPR011330"
/db_xref="InterPro:IPR011682"
/db_xref="InterPro:IPR015341"
/db_xref="InterPro:IPR018905"
/db_xref="InterPro:IPR027291"
/db_xref="InterPro:IPR028995"
/db_xref="InterPro:IPR037094"
/db_xref="UniProtKB/TrEMBL:P96937"
/inference="protein motif:PROSITE:PS00659"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43391.1"
/translation="MMGGTYNEPNTNLTSPETTIRNLVHGIGFQRDVLGAEPATAWQL
DVFGHDPQFPGLAADAGLTSSSWARGPHHQWGPAQGGVDRMQFCSEFEWIAPSGRGLL
THYMPAHYSAGWSMDSSTSLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPPNKWV
TAIHRDWGARYTWPRFVCALPKEFFAAVRAELAKRGWVPSPQTRDMNPIYTGKDVSYI
DTKQANRAAENAVLEAERFAVFAALLTGAEYPQAALAKAWVQLAYGAHHDAITGSESD
QVYLDLLTGWRDAWELGRAARDNSLRLLSGAVAASHDRVVVWNPLTQRRTDIVTARVD
PPLQAGVRVFDPDGAEVAALVEHDGRSVTWLACDVPSLGWRVYRLVPADEAPGWELVP
GTDIANEHYRLAVDPERGGALSSLVQDGRQLIAAGRVANELALYEEYPSHPTQGEGPW
HLLPTGPVVCSSACPAQVQAYRGPLGQRLVVRGRIGTLLRYTQTLTLWDGVDRVDCRT
SIDEFTGEDRLLRLRWPCPVPGAMPISEVGDAVVGRGFALLHEGPESVDTAQHPWTLD
NPAYGWFGLSSAVRVRAGDGVRAVSVAEVVSPTETVSGPMARDLMVALVRAGVTATCS
GADKPRYGHLDVDSNLPDARIALGGPDRNTFTKAVLAEAAPAYTAELQRQLAKTGTAR
VWVPAANPLARAWLPGADLRAPCALPVLVIDGRDEKHLRAAVASLADDLADAEIVVHQ
RAAPQMEPFEDRTVALLNRGVPSFAVDSEGTLHTALMRSCTGWPSGVWIDQPRRTAPD
GSNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLAVAPRRPQGELPAVGSL
LHVEPADSVQLGALKAAGNPLAAGSARPVQPAAVALRLVQTTGADTPVTIGCELGKVG
ALRPADLLETPLAMARARKSSIDLHGYQVATVLARLDVAADMANVLAADDVALAPHAE
TAQPQYARYWLHNRGPAPLGGLPAVAHLHPRRVRGQPGDDVVLRLTAASDCTDSVLGG
VVDVVCPLGWPATPARLPFTLGAGAHLQADIALSIPAGAPPGPYPVRAQLRVVDTAVP
AAWRQVVEDVCVVTVGADSDLEELVYLVDGPADIELAAGDRARLAVTIGSRAHAELAL
DAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLEPGQWWALVRVGCAGQL
VYSPAVKVSVT"
gene 746363..747037
/gene="fabD2"
/locus_tag="Rv0649"
CDS 746363..747037
/codon_start=1
/transl_table=11
/gene="fabD2"
/locus_tag="Rv0649"
/product="Possible malonyl CoA-acyl carrier protein
transacylase FabD2 (MCT)"
/note="Rv0649, (MTCY20H10.30), len: 224 aa. Possible
fabD2,malonyl CoA-acyl carrier protein transacylase,
similar to mtfabd|FABD_MYCTU|Q10501|Rv2243 malonyl
CoA-acyl carrier protein transacylase from Mycobacterium
tuberculosis (302 aa), FASTA scores: opt: 133, E(): 0.074,
(31.3% identity in 147 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0649"
/db_xref="EnsemblGenomes-Tr:CCP43392"
/db_xref="GOA:Q79FX5"
/db_xref="InterPro:IPR027304"
/db_xref="UniProtKB/TrEMBL:Q79FX5"
/protein_id="CCP43392.1"
/translation="MSGRSRLPGSSSRRDAARIVAERVVATVAGVAVAVDEVDAAEAR
LRDGPRAAALPASGTSEGRQLRRWLTQLIVTERVVAAEAAARGLTAAGAPAEADLLPD
ATARLEIGSVAAAVLADPLARALFAAVTARVAVTDDAVADYHARNPLRFAAPCPGQHG
WRAPAAAAPPLDQVRRAITEHLLGAARRRAFRVWLDARRNALVVLAPGYEHPGDPRQP
DNTRRH"
gene 747037..747945
/locus_tag="Rv0650"
CDS 747037..747945
/codon_start=1
/transl_table=11
/locus_tag="Rv0650"
/product="Possible sugar kinase"
/note="Rv0650, (MTCY20H10.31), len: 302 aa. Possible sugar
kinase, highly similar to others e.g. CAB95296.1|AL359779
putative sugar kinase from Streptomyces coelicolor (317
aa); NP_406512.1|NC_003143 putative sugar kinase from
Yersinia pestis (290 aa); NP_229269.1|NC_000853
glucokinase from Thermotoga maritima (317 aa);
etc.Contains PS01125 ROK family signature. Belongs to the
ROK (NAGC/XYLR) family."
/db_xref="EnsemblGenomes-Gn:Rv0650"
/db_xref="EnsemblGenomes-Tr:CCP43393"
/db_xref="GOA:I6Y8D3"
/db_xref="InterPro:IPR000600"
/db_xref="UniProtKB/TrEMBL:I6Y8D3"
/inference="protein motif:PROSITE:PS01125"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43393.1"
/translation="MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAA
VAEMIADALGVAGGAVGGVGIASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVPGV
PVRLGGDGVCMALGEHWLGAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVG
HVVVDPDGSPCPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPV
ALRAFRRGAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFL
AGLRVVPAELGGAAGLVGAARLAAIA"
gene 748276..748812
/gene="rplJ"
/locus_tag="Rv0651"
CDS 748276..748812
/codon_start=1
/transl_table=11
/gene="rplJ"
/locus_tag="Rv0651"
/product="50S ribosomal protein L10 RplJ"
/note="Rv0651, (MTCY20H10.32), len: 178 aa. rplJ, 50S
ribosomal protein L10, equivalent to NP_302276.1|NC_002677
50S ribosomal protein L10 from Mycobacterium leprae (177
aa). Also highly similar to others e.g. P36257|RL10_STRGR
50s ribosomal protein L10 from Streptomyces griseus (185
aa), FASTA scores: opt: 633, E(): 0, (59.0 % identity in
173 aa overlap); etc. Belongs to the L10P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0651"
/db_xref="EnsemblGenomes-Tr:CCP43394"
/db_xref="GOA:P9WHE7"
/db_xref="InterPro:IPR001790"
/db_xref="InterPro:IPR002363"
/db_xref="InterPro:IPR022973"
/db_xref="UniProtKB/Swiss-Prot:P9WHE7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43394.1"
/translation="MARADKATAVADIAAQFKESTATLITEYRGLTVANLAELRRSLT
GSATYAVAKNTLIKRAASEAGIEGLDELFVGPTAIAFVTGEPVDAAKAIKTFAKEHKA
LVIKGGYMDGHPLTVAEVERIADLESREVLLAKLAGAMKGNLAKAAGLFNAPASQLAR
LAAALQEKKACPGPDSAE"
gene 748849..749241
/gene="rplL"
/gene_synonym="L7|L12"
/locus_tag="Rv0652"
CDS 748849..749241
/codon_start=1
/transl_table=11
/gene="rplL"
/gene_synonym="L7|L12"
/locus_tag="Rv0652"
/product="50S ribosomal protein L7/L12 RplL (SA1)"
/note="Rv0652, (MTCY20H10.33), len: 130 aa. rplL
(alternate gene name: L7|L12), 50S ribosomal protein
L7/L12,equivalent to NP_302275.1|NC_002677 50S ribosomal
protein L7/L12 from Mycobacterium leprae (130 aa); and
P37381|RL7_MYCBO 50s ribosomal protein L7/L12 from
Mycobacterium bovis (130 aa). Also highly similar to
others e.g. P02396|RL7_STRGR 50S ribosomal protein L7/L12
from Streptomyces griseus (127 aa); etc. Belongs to the
L12P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0652"
/db_xref="EnsemblGenomes-Tr:CCP43395"
/db_xref="GOA:P9WHE3"
/db_xref="InterPro:IPR000206"
/db_xref="InterPro:IPR008932"
/db_xref="InterPro:IPR013823"
/db_xref="InterPro:IPR014719"
/db_xref="InterPro:IPR036235"
/db_xref="UniProtKB/Swiss-Prot:P9WHE3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43395.1"
/translation="MAKLSTDELLDAFKEMTLLELSDFVKKFEETFEVTAAAPVAVAA
AGAAPAGAAVEAAEEQSEFDVILEAAGDKKIGVIKVVREIVSGLGLKEAKDLVDGAPK
PLLEKVAKEAADEAKAKLEAAGATVTVK"
gene complement(749234..749929)
/locus_tag="Rv0653c"
CDS complement(749234..749929)
/codon_start=1
/transl_table=11
/locus_tag="Rv0653c"
/product="Possible transcriptional regulatory protein
(probably TetR-family)"
/note="Rv0653c, (MTCI376.23, MTCY20H10.34c), len: 231 aa.
Possible transcriptional regulator, TetR family, similar
in N-terminus to others e.g. CAC03642.1|AL391338 putative
TetR-family transcriptional regulator from Streptomyces
coelicolor (190 aa); Q51597 cam repressor from Pseudomonas
putida (186 aa), FASTA scores: opt: 150, E():
0.00085,(27.8% identity in 97 aa overlap); etc. Also some
similarity to Mycobacterium tuberculosis hypothetical
transcriptional regulators Rv0681 and Rv1816. Contains
probable helix-turn helix motif from aa 27-48 (Score
1156,+3.12 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0653c"
/db_xref="EnsemblGenomes-Tr:CCP43396"
/db_xref="GOA:P96941"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR025996"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:P96941"
/protein_id="CCP43396.1"
/translation="MTSQTGVRDELLHAGVRLLDDHGPDALQTRKVAAAAGTSTMAVY
THFGGMRGLIAAIAEEGLRQFDVALTVPQTADPVADLLAIGTAYRRYAIERPHMYRLM
FGSTSAHGINVPARDVLTLKVAEIEHQHPSFAHVVRAVHRCLLAGRFATALGADDDTA
IVATAAQFWSQIHGFVMLELAGFYGDRGAAVEPVLAAMTVNLLVALGDSPERAQCSLR
AEQTQKNTLGRAT"
gene 750000..751505
/locus_tag="Rv0654"
CDS 750000..751505
/codon_start=1
/transl_table=11
/locus_tag="Rv0654"
/product="Probable dioxygenase"
/note="Rv0654, (MTCI376.22), len: 501 aa. Probable
dioxygenase, highly similar to others eg
AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase
(involved in tetraene formation) from Streptomyces
antibioticus (456 aa); CAB56138.1| AL117669 putative
dioxygenase from Streptomyces coelicolor (503 aa); T51734
neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid
dioxygenase) from Arabidopsis thaliana (538 aa); Q53353
lignostilbene-alpha,beta-dioxygenase from Pseudomonas
paucimobilis (Sphingomonas paucimobilis), FASTA scores:
opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa
overlap); etc. Also some similarity with
Rv0913c|MTCY21C12.07c possible dioxygenase from
Mycobacterium tuberculosis (501 aa), FASTA score: (29.5%
identity in 522 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0654"
/db_xref="EnsemblGenomes-Tr:CCP43397"
/db_xref="GOA:P9WPR5"
/db_xref="InterPro:IPR004294"
/db_xref="UniProtKB/Swiss-Prot:P9WPR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43397.1"
/translation="MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRY
LRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALGEPISA
RPHPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVGPCDFDGTLHGGYT
AHPQRDPHTGELHAVSYSFARGHRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDN
YVVIYDLPVTFDPMQVVPASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSD
RLPYAWNPSYPARVGVMPREGGNEDVRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVV
RYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHR
FAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFVPNPSARAE
DDGILMGYGWHRGRDEGQLLLLDAQTLESIATVHLPQRVPMGFHGNWAPTT"
gene 751517..752596
/gene="mkl"
/locus_tag="Rv0655"
CDS 751517..752596
/codon_start=1
/transl_table=11
/gene="mkl"
/locus_tag="Rv0655"
/product="Possible ribonucleotide-transport ATP-binding
protein ABC transporter Mkl"
/note="Rv0655, (MTCI376.21), len: 359 aa. Possible
mkl,ribonucleotide-transport ATP-binding protein ABC
transporter (see Braibant et al., 2000), equivalent to
P30769|MKL_MYCLE|ML1892 possible ribonucleotide transport
ATP-binding protein from Mycobacterium leprae (347
aa),FASTA scores: opt: 2021, E(): 0, (92.2% identity in
335 aa overlap). Also highly similar to many e.g.
AB92896.1|AL356992 putative ABC-transporter ATP-binding
protein from Streptomyces coelicolor (343 aa);
NP_253146.1|NC_002516 probable ATP-binding component of
ABC transporter from Pseudomonas aeruginosa (269 aa);
P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding
protein from Escherichia coli (269 aa), FASTA scores: opt:
644, E(): 3.4e-33, (38.5% identity in 244 aa overlap);
etc. Also similar to many other Mycobacterium tuberculosis
ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351
aa),FASTA score: (33.6% identity in 241 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A (P-loop),
PS00211 ABC transporters family signature. Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv0655"
/db_xref="EnsemblGenomes-Tr:CCP43398"
/db_xref="GOA:P9WQL5"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR030296"
/db_xref="UniProtKB/Swiss-Prot:P9WQL5"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43398.1"
/translation="MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWE
DVTLTIPAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELYEI
RTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLALVGLGGDEKKF
PGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQIDATIL
IVTHNINIARTVPDNMGMLFRKHLVMFGPREVLLTSDEPVVRQFLNGRRIGPIGMSEE
KDEATMAEEQALLDAGHHAGGVEEIEGVPPQISATPGMPERKAVARRQARVREMLHTL
PKKAQAAILDDLEGTHKYAVHEIGQ"
gene complement(752984..753367)
/gene="vapC6"
/locus_tag="Rv0656c"
CDS complement(752984..753367)
/codon_start=1
/transl_table=11
/gene="vapC6"
/locus_tag="Rv0656c"
/product="Possible toxin VapC6"
/note="Rv0656c, (MTCI376.20), len: 127 aa. Possible
vapC6,toxin, part of toxin-antitoxin (TA) operon with
Rv0657c,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to other proteins from
Mycobacterium tuberculosis e.g. Rv2757c, Rv2546, etc. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0656c"
/db_xref="EnsemblGenomes-Tr:CCP43399"
/db_xref="GOA:P9WFB5"
/db_xref="InterPro:IPR022907"
/db_xref="UniProtKB/Swiss-Prot:P9WFB5"
/protein_id="CCP43399.1"
/translation="MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQ
MSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVGALSVVDLLICDTAAARGLVVLH
DDADYELAERHLPDIRVRRVVSADD"
gene complement(753462..753617)
/gene="vapB6"
/locus_tag="Rv0657c"
CDS complement(753462..753617)
/codon_start=1
/transl_table=11
/gene="vapB6"
/locus_tag="Rv0657c"
/product="Possible antitoxin VapB6"
/note="Rv0657c, (MTCI376.19), len: 51 aa. Possible
vapB6,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0656c (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Similarity with others from Mycobacterium tuberculosis
e.g. Rv2009|MT2064.1|MTCY39.08c|YW08_MYCTU|Q10848 (80 aa),
FASTA scores: opt: 107, E(): 0.0038, (45.8% identity in 48
aa overlap), Rv2871, Rv1560, etc. Also some similarity
with AL020958|SC4H8_7 from Streptomyces coelicolor (66
aa),FASTA score: (41.0% identity in 39 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0657c"
/db_xref="EnsemblGenomes-Tr:CCP43400"
/db_xref="InterPro:IPR019239"
/db_xref="UniProtKB/Swiss-Prot:P9WJ57"
/protein_id="CCP43400.1"
/translation="MSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIE
ALARSRE"
gene complement(753693..754409)
/locus_tag="Rv0658c"
CDS complement(753693..754409)
/codon_start=1
/transl_table=11
/locus_tag="Rv0658c"
/product="Probable conserved integral membrane protein"
/note="Rv0658c, (MTCI376.18), len: 238 aa. Probable
conserved integral membrane protein, equivalent to a
predicted homologous protein from Mycobacterium smegmatis
(see citation below), and showing some similarity with
P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from
Escherichia coli (217 aa), FASTA scores: opt: 174, E():
5.3e-05, (25.6% identity in 223 aa overlap). Also similar
to Rv1863c and Rv0804 from Mycobacterium tuberculosis.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0658c"
/db_xref="EnsemblGenomes-Tr:CCP43401"
/db_xref="GOA:O06781"
/db_xref="InterPro:IPR003675"
/db_xref="UniProtKB/TrEMBL:O06781"
/protein_id="CCP43401.1"
/translation="MEAGRADTVAPSHRWGLGAFLVVELVFLVASTSLAVVLTGHGPV
SAGVLALALAAPTVVAAGLAILITRLRGNGLRTDLRLRWSWRGLRLGLMFGFGGMLVT
IPASLVYTAIVGPEANSAVVRIFGGVRASWPWALVVFLVVVFVAPLCEEIIYRGLLWG
AVDRRWGRWAALVVTTVVFALAHLEFARAPLLVVVAIPIALARFYSGGLLASIVTHQV
TNLLPGIVLLLGLTGAISLP"
gene complement(754685..754993)
/gene="mazF2"
/gene_synonym="mt4"
/locus_tag="Rv0659c"
CDS complement(754685..754993)
/codon_start=1
/transl_table=11
/gene="mazF2"
/gene_synonym="mt4"
/locus_tag="Rv0659c"
/product="Toxin MazF2"
/note="Rv0659c, (MTCI376.17), len: 102 aa. MazF2,
toxin,part of toxin-antitoxin (TA) operon with Rv0660c
(See Pandey and Gerdes, 2005; Zhu et al., 2006), weakly
similar to other Mycobacterium tuberculosis hypothetical
proteins e.g. Rv1942c, Rv1495, etc. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0659c"
/db_xref="EnsemblGenomes-Tr:CCP43402"
/db_xref="GOA:P9WII1"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="UniProtKB/Swiss-Prot:P9WII1"
/protein_id="CCP43402.1"
/translation="MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRG
LVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRRITRLSPARLHEACQTLRASTGC
"
gene complement(754980..755225)
/gene="mazE2"
/locus_tag="Rv0660c"
CDS complement(754980..755225)
/codon_start=1
/transl_table=11
/gene="mazE2"
/locus_tag="Rv0660c"
/product="Possible antitoxin MazE2"
/note="Rv0660c, (MTCI376.16), len: 81 aa. Possible
mazE2,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0659c (See Pandey and Gerdes, 2005; Zhu et al., 2006),
showing some similarity to AF016485_130 from Halobacterium
sp (100 aa), FASTA scores: (32.4% identity in 74 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0660c"
/db_xref="EnsemblGenomes-Tr:CCP43403"
/db_xref="GOA:O06779"
/db_xref="InterPro:IPR002145"
/db_xref="UniProtKB/Swiss-Prot:O06779"
/protein_id="CCP43403.1"
/translation="MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQ
DVQAYTERPLTDDENALAEIADWGPAEDWADWADAAR"
gene complement(755335..755772)
/gene="vapC7"
/locus_tag="Rv0661c"
CDS complement(755335..755772)
/codon_start=1
/transl_table=11
/gene="vapC7"
/locus_tag="Rv0661c"
/product="Possible toxin VapC7"
/note="Rv0661c, (MTCI376.15), len: 145 aa. Possible
vapC7,toxin, part of toxin-antitoxin (TA) operon with
Rv0662c,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to others in
Mycobacterium tuberculosis e.g. Rv2863|MTV003.09|MTV003_7
(126 aa), FASTA scores: E(): 0.00087, (30.4% identity in
125 aa overlap),Rv0749|MTV041.23 (163 aa); Rv0277c,
Rv2530c, etc. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0661c"
/db_xref="EnsemblGenomes-Tr:CCP43404"
/db_xref="GOA:P9WFB3"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFB3"
/protein_id="CCP43404.1"
/translation="MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVI
QEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIEATSKRGLTLFETTPGLEACDAV
LAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR"
gene complement(755769..756023)
/gene="vapB7"
/locus_tag="Rv0662c"
CDS complement(755769..756023)
/codon_start=1
/transl_table=11
/gene="vapB7"
/locus_tag="Rv0662c"
/product="Possible antitoxin VapB7"
/note="Rv0662c, (MTCI376.14), len: 84 aa. Possible
vapB7,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0661c (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Similarity with others from Mycobacterium tuberculosis
e.g. Rv2871, Rv1241, Rv2550c, etc. Start changed since
first submission, now 38 aa shorter. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0662c"
/db_xref="EnsemblGenomes-Tr:CCP43405"
/db_xref="GOA:O06777"
/db_xref="UniProtKB/Swiss-Prot:O06777"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43405.1"
/translation="MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGL
VSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALRARRG"
gene 756137..758500
/gene="atsD"
/locus_tag="Rv0663"
CDS 756137..758500
/codon_start=1
/transl_table=11
/gene="atsD"
/locus_tag="Rv0663"
/product="Possible arylsulfatase AtsD (aryl-sulfate
sulphohydrolase) (arylsulphatase)"
/note="Rv0663, (MTCI376.13c), len: 787 aa. Possible
atsD,arylsulfatase, similar to others e.g. P5169|ARS_PSEAE
arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA
scores: opt: 653, E(): 0, (33.1% identity in 544 aa
overlap); etc. Also similar to
P95059|MTCY210.30|ATSA|Rv0711|MTCY210.30 from
Mycobacterium tuberculosis (787 aa), FASTA score: (38.9%
identity in 769 aa overlap); and other arylsulfatases from
Mycobacterium tuberculosis e.g. Rv3299c|ATSB (970 aa),
Rv0711, etc. Contains PS00523 Sulfatases signature 1.
Belongs to the sulfatase family. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0663"
/db_xref="EnsemblGenomes-Tr:CCP43406"
/db_xref="GOA:I6XVW9"
/db_xref="InterPro:IPR000917"
/db_xref="InterPro:IPR013320"
/db_xref="InterPro:IPR017850"
/db_xref="InterPro:IPR024607"
/db_xref="UniProtKB/TrEMBL:I6XVW9"
/inference="protein motif:PROSITE:PS00523"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43406.1"
/translation="MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPN
VLLILLDDVGFGASSAFGGPCRTSTAELLAGNGLRYNRFHTTALCSPTRQALLTGRNH
HSAGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGYNTAQFGKCHEVPVWQTSPVG
PFDAWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTPVEVNRTPEEGYHFMADMTDKAL
GWIGQQKALAPDRPFFVYFAPGATHAPHHVPREWADKYRGRFDVGWDALREETFARQK
ELGVIPADCQLTARHAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLVDGLQ
RLGVLDDTLVFYIIDDNGASAEGTINGTYNEMLNFNGLADIETPRFMTDRLDKFGGPE
SYNHYSVGWAHAMDTPYQWTKQVASHWGGTRNGTIVHWPNGIAAKGEMRWQFHHVIDV
APTILEAAGLPEPLFVNGVQQHPIEGVSMAYSFDDAQAPDRHETQYFEMFGNRGIYHK
GWTAVTKHKTPWILVGEQTVAFDDDVWELYDTTKDWSQAKDLAKEMPEKLHELQRLWL
IEATRYNVLPLDDDTASRINPDLAGRPVLIRGNTQVLFSNMGRLSENCVLNLKNKSHT
VTAEVEVPETGAEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPLPAG
AHQVRMEFAYAGGGLGKGGEVTLYVDGQQVGEGHVEATLAIVFSADDGCDVGMDSGSP
VSPDYAPGSNAFNGRIKGVQLAIAEAAAAAGHLVDPEHAIRIALARQ"
gene 758532..758804
/gene="vapB8"
/locus_tag="Rv0664"
CDS 758532..758804
/codon_start=1
/transl_table=11
/gene="vapB8"
/locus_tag="Rv0664"
/product="Possible antitoxin VapB8"
/note="Rv0664, (MTCI376.12c), len: 90 aa. Possible
vapB8,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0665 (See Arcus et al., 2005; Pandey and Gerdes, 2005).
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0664"
/db_xref="EnsemblGenomes-Tr:CCP43407"
/db_xref="UniProtKB/Swiss-Prot:O06775"
/protein_id="CCP43407.1"
/translation="MEKSRCHAVAHGGGCAGSAKSHKSGGRCGQGRGAGDSHGTRGAG
RRYRAASAPHPLAVGAHLRDELAKRSADPRLTDELNDLAGHTLDDL"
gene 758801..759139
/gene="vapC8"
/locus_tag="Rv0665"
CDS 758801..759139
/codon_start=1
/transl_table=11
/gene="vapC8"
/locus_tag="Rv0665"
/product="Possible toxin VapC8"
/note="Rv0665, (MTCI376.11c), len: 112 aa. Possible
vapC8,toxin, part of toxin-antitoxin (TA) operon with
Rv0664,contains PIN domain (See Arcus et al. 2005; Pandey
and Gerdes, 2005). Similar to others in Mycobacterium
tuberculosis e.g. Rv0627 (135 aa), and Rv0595c. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0665"
/db_xref="EnsemblGenomes-Tr:CCP43408"
/db_xref="GOA:P9WFB1"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFB1"
/protein_id="CCP43408.1"
/translation="MTEGEVGVGLLDTSVFIARESGGAIADLPERVALSVMTIGELQL
GLLNAGDSATRSRRADTLALARTADQIPVSEAVMISLARLVADCRAAGVRRSVKLTDA
LIAATAEIKV"
gene 759136..759309
/locus_tag="Rv0666"
CDS 759136..759309
/codon_start=1
/transl_table=11
/locus_tag="Rv0666"
/product="Possible membrane protein"
/note="Rv0666, (MTCI376.10c), len: 57 aa. Possible
membrane protein; has hydrophobic stretch at aa 29-47.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0666"
/db_xref="EnsemblGenomes-Tr:CCP43409"
/db_xref="UniProtKB/TrEMBL:O06773"
/protein_id="CCP43409.1"
/translation="MTPRTDEGAAAPCLMPDVTMPVKRGDARGALGVGPALFVVSVSS
SLVRARSCRCTAD"
gene 759807..763325
/gene="rpoB"
/locus_tag="Rv0667"
CDS 759807..763325
/codon_start=1
/transl_table=11
/gene="rpoB"
/locus_tag="Rv0667"
/product="DNA-directed RNA polymerase (beta chain) RpoB
(transcriptase beta chain) (RNA polymerase beta subunit)"
/note="Rv0667, (MTCI376.08c), len: 1172 aa.
RpoB,DNA-directed RNA polymerase, beta chain (see Miller
et al.,1994; Ahmad et al., 2000), equivalent to
P30760|RPOB_MYCLE|ML1891 DNA-directed RNA polymerase beta
chain from Mycobacterium leprae (1178 aa). Also highly
similar to others e.g. AAF60349.1|AF242549_1|AF242549
DNA-dependent RNA polymerase beta subunit from
Amycolatopsis mediterranei (1167 aa); CAB77428.1|AL160431
DNA-directed RNA polymerase beta chain from Streptomyces
coelicolor (1161 aa); etc. Start site chosen on basis of
RBS but alternative start exists at position 14359.
Belongs to the RNA polymerase beta chain family."
/db_xref="EnsemblGenomes-Gn:Rv0667"
/db_xref="EnsemblGenomes-Tr:CCP43410"
/db_xref="GOA:P9WGY9"
/db_xref="InterPro:IPR007120"
/db_xref="InterPro:IPR007121"
/db_xref="InterPro:IPR007641"
/db_xref="InterPro:IPR007642"
/db_xref="InterPro:IPR007644"
/db_xref="InterPro:IPR007645"
/db_xref="InterPro:IPR010243"
/db_xref="InterPro:IPR014724"
/db_xref="InterPro:IPR015712"
/db_xref="InterPro:IPR019462"
/db_xref="InterPro:IPR037033"
/db_xref="InterPro:IPR037034"
/db_xref="InterPro:IPR042107"
/db_xref="PDB:4KBJ"
/db_xref="PDB:4KBM"
/db_xref="PDB:5UH5"
/db_xref="PDB:5UH6"
/db_xref="PDB:5UH8"
/db_xref="PDB:5UH9"
/db_xref="PDB:5UHA"
/db_xref="PDB:5UHB"
/db_xref="PDB:5UHC"
/db_xref="PDB:5UHD"
/db_xref="PDB:5UHE"
/db_xref="PDB:5UHF"
/db_xref="PDB:5UHG"
/db_xref="PDB:5ZX2"
/db_xref="PDB:5ZX3"
/db_xref="PDB:6BZO"
/db_xref="PDB:6C04"
/db_xref="PDB:6C05"
/db_xref="PDB:6C06"
/db_xref="PDB:6DV9"
/db_xref="PDB:6DVB"
/db_xref="PDB:6DVC"
/db_xref="PDB:6DVD"
/db_xref="PDB:6DVE"
/db_xref="PDB:6EDT"
/db_xref="PDB:6EE8"
/db_xref="PDB:6EEC"
/db_xref="PDB:6FBV"
/db_xref="PDB:6JCX"
/db_xref="PDB:6JCY"
/db_xref="PDB:6M7J"
/db_xref="UniProtKB/Swiss-Prot:P9WGY9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43410.1"
/translation="MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEV
PGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFS
DPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTF
IINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGV
RIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLR
PGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVA
TIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMER
VVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLS
ALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIET
PYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVP
SSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGM
ELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCP
IVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDV
LTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVG
KVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELP
AGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTH
GVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFD
GAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHL
VDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSD
DTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGED
EDLERAAANLGINLSRNESASVEDLA"
gene 763370..767320
/gene="rpoC"
/locus_tag="Rv0668"
CDS 763370..767320
/codon_start=1
/transl_table=11
/gene="rpoC"
/locus_tag="Rv0668"
/product="DNA-directed RNA polymerase (beta' chain) RpoC
(transcriptase beta' chain) (RNA polymerase beta'
subunit)."
/note="Rv0668, (MTCI376.07c), len: 1316 aa.
RpoC,DNA-directed RNA polymerase, beta' chain (see Miller
et al., 1994), equivalent to
P30761|RPOC_MYCLE|ML1890|S31146 DNA-directed RNA
polymerase beta' chain from Mycobacterium leprae (1316
aa), FASTA scores: opt: 8295, E(): 0, (95.6% identity in
1316 aa overlap). Also highly similar to others e.g.
CAB77429.1|AL160431 DNA-directed RNA polymerase beta'
chain (fragment) from Streptomyces coelicolor (1059 aa);
P37871|RPOC_BACSU from Bacillus subtilis (1199 aa), FASTA
scores: opt: 2367, E(): 0, (52.9 identity in 1317 aa
overlap); etc. Belongs to the RNA polymerase beta' chain
family."
/db_xref="EnsemblGenomes-Gn:Rv0668"
/db_xref="EnsemblGenomes-Tr:CCP43411"
/db_xref="GOA:P9WGY7"
/db_xref="InterPro:IPR000722"
/db_xref="InterPro:IPR006592"
/db_xref="InterPro:IPR007066"
/db_xref="InterPro:IPR007080"
/db_xref="InterPro:IPR007081"
/db_xref="InterPro:IPR007083"
/db_xref="InterPro:IPR012754"
/db_xref="InterPro:IPR038120"
/db_xref="InterPro:IPR042102"
/db_xref="PDB:5UH5"
/db_xref="PDB:5UH6"
/db_xref="PDB:5UH7"
/db_xref="PDB:5UH8"
/db_xref="PDB:5UH9"
/db_xref="PDB:5UHA"
/db_xref="PDB:5UHB"
/db_xref="PDB:5UHC"
/db_xref="PDB:5UHD"
/db_xref="PDB:5UHE"
/db_xref="PDB:5UHF"
/db_xref="PDB:5UHG"
/db_xref="PDB:5ZX2"
/db_xref="PDB:5ZX3"
/db_xref="PDB:6BZO"
/db_xref="PDB:6C04"
/db_xref="PDB:6C05"
/db_xref="PDB:6C06"
/db_xref="PDB:6DV9"
/db_xref="PDB:6DVB"
/db_xref="PDB:6DVC"
/db_xref="PDB:6DVD"
/db_xref="PDB:6DVE"
/db_xref="PDB:6EDT"
/db_xref="PDB:6EE8"
/db_xref="PDB:6EEC"
/db_xref="PDB:6FBV"
/db_xref="PDB:6JCX"
/db_xref="PDB:6JCY"
/db_xref="PDB:6M7J"
/db_xref="UniProtKB/Swiss-Prot:P9WGY7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43411.1"
/translation="MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKD
GLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVT
HIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERK
AVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREMRQIRDRAQRELDR
LEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAES
LRDVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGR
FATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVT
GPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALE
LFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLG
IQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNIL
SPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGDHPETGVYSSPAEAIMAADR
GVLSVRAKIKVRLTQLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYP
FVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPP
RKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNP
IITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGA
RKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDP
YIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKVRSVLTCATST
GVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPR
VQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRV
FKHEDGSERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQG
VSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGR
PVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGT
GINRYRNIAVQPTEEARAAAYTIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR"
gene complement(767684..769597)
/locus_tag="Rv0669c"
CDS complement(767684..769597)
/codon_start=1
/transl_table=11
/locus_tag="Rv0669c"
/product="Possible hydrolase"
/note="Rv0669c, (MTCI376.05), len: 637 aa. Possible
hydrolase, highly similar to various hydrolases
(N-terminus shorter) e.g. BAA88409.1|AB028646 alkaline
ceramidase from Pseudomonas aeruginosa (670 aa,) FASTA
scores: opt: 1490,E(): 0, (41.2% identity in 651 aa
overlap); NP_063946.1|NM_019893 mitochondrial ceramidase
from Homo sapiens (761 aa); P_446098.1|NM_053646
N-acylsphingosine amidohydrolase 2 from Rattus norvegicus
(761 aa); BAB09641.1|AB016885 neutral ceramidase from
Arabidopsis thaliana (705 aa); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0669c"
/db_xref="EnsemblGenomes-Tr:CCP43412"
/db_xref="GOA:O06769"
/db_xref="InterPro:IPR006823"
/db_xref="InterPro:IPR031329"
/db_xref="InterPro:IPR031331"
/db_xref="InterPro:IPR038445"
/db_xref="UniProtKB/Swiss-Prot:O06769"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43412.1"
/translation="MLSVGRGIADITGEAADCGMLGYGKSDQRTAGIHQRLRSRAFVF
RDDSQDGDARLLLIVAELPLPMQNVNEEVLRRLADLYGDTYSEQNTLITATHTHAGPG
GYCGYLLYNLTTSGFRPATFAAIVDGIVESVEHAHADVAPAEVSLSHGELYGASINRS
PSAFDRNPPADKAFFPKRVDPHTTLVRIDRGEATVGVIHFFATHGTSMTNRNHLISGD
NKGFAAYHWERTVGGADYLAGQPDFIAAFAQTNPGDMSPNVDGPLSPEAPPDREFDNT
RRTGLCQFEDAFTQLSGATPIGAGIDARFTYVDLGSVLVRGEYTPDGEERRTGRPMFG
AGAMAGTDEGPGFHGFRQGRNPFWDRLSRAMYRLARPTAAAQAPKGIVMPARLPNRIH
PFVQEIVPVQLVRIGRLYLIGIPGEPTIVAGLRLRRMVASIVGADLADVLCVGYTNAY
IHYVTTPEEYLEQRYEGGSTLFGRWELCALMQTVAELAEAMRDGRPVTLGRRPRPTRE
LSWVRGAPADAGSFGAVIAEPSATYRPGQAVEAVFVSALPNNDLRRGGTYLEVVRREG
ASWVRIADDGDWATSFRWQRQGRAGSHVSIRWDVPGDTTPGQYRIVHHGTARDRNGML
TAFSATTREFTVV"
gene 769792..770550
/gene="end"
/gene_synonym="nfo"
/locus_tag="Rv0670"
CDS 769792..770550
/codon_start=1
/transl_table=11
/gene="end"
/gene_synonym="nfo"
/locus_tag="Rv0670"
/product="Probable endonuclease IV End
(endodeoxyribonuclease IV) (apurinase)"
/note="Rv0670, (MTCI376.04c), len: 252 aa. Probable end
(alternate gene name: nfo), endonuclease IV (apurinase)
(see citation below), equivalent to
END_MYCLE|P30770|NFO|ML1889 probable endonuclease IV
(apurinase) from Mycobacterium leprae (252 aa), FASTA
scores: opt: 1463, E(): 0, (85.6% identity in 250 aa
overlap). Also similar to others e.g.
Q9S2N2|END4_STRCO|NFO|SC6E10.05 probable endonuclease IV
from Streptomyces coelicolor (294 aa); etc. Contains
PS00729 AP endonucleases family 2 signatures 1 and 2
(PS00729, and PS00730). Belongs to the AP endonucleases
family 2. Cofactor: binds 3 zinc ions. The transcription
of this CDS seems negatively regulated by the product of
mce2R|Rv0586 (See Santangelo et al., 2009)."
/db_xref="EnsemblGenomes-Gn:Rv0670"
/db_xref="EnsemblGenomes-Tr:CCP43413"
/db_xref="GOA:P9WQ13"
/db_xref="InterPro:IPR001719"
/db_xref="InterPro:IPR013022"
/db_xref="InterPro:IPR018246"
/db_xref="InterPro:IPR036237"
/db_xref="PDB:5ZHZ"
/db_xref="UniProtKB/Swiss-Prot:P9WQ13"
/inference="protein motif:PROSITE:PS00729"
/inference="protein motif:PROSITE:PS00730"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43413.1"
/translation="MLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAA
ALKAATLPIYVHAPYLINLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVAD
DNDIDKGFQRWRKALDRLETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFC
LDTCHTWAAGEALTDAVDRIKAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDL
LVAAVKAAGAPVICETADQGRKDDIAFLRERTGS"
gene 770582..771424
/gene="lpqP"
/locus_tag="Rv0671"
CDS 770582..771424
/codon_start=1
/transl_table=11
/gene="lpqP"
/locus_tag="Rv0671"
/product="Possible conserved lipoprotein LpqP"
/note="Rv0671, (MTCI376.03c), len: 280 aa. Possible
lpqP,conserved lipoprotein, similar to
U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302
aa), FASTA scores: opt: 449,E(): 2.4e-22, (37.6% identity
in 242 aa overlap). Also highly similar to
lpqC|Rv3298c|MTCY71.38c putative lipoprotein from
Mycobacterium tuberculosis (304 aa). Also similar to a
large variety of proteins including various esterases and
poly(3-hydroxyalkanoate) depolymerases, e.g.
NP_249234.1|NC_002516 hypothetical protein from
Pseudomonas aeruginosa (322 aa); C-terminus of
AAD45376.1|AF164516_1|AF164516 cinnamoyl ester hydrolase
EstA from Piromyces equi (536 aa); part of
P52090|PHA1_PSELE poly(3-hydroxyalkanoate) depolymerase C
precursor from Pseudomonas lemoignei (414 aa);
CAC10310.1|AL442629 putative secreted protein from
Streptomyces coelicolor (348 aa); etc. Has a 17 aa signal
sequence and contains appropriately positioned (PS00013)
Prokaryotic membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0671"
/db_xref="EnsemblGenomes-Tr:CCP43414"
/db_xref="GOA:I6XVY0"
/db_xref="InterPro:IPR010126"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6XVY0"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP43414.1"
/translation="MLRRVAILLAAVLAFAGCSGGTRLAAGFGNGNSVHTLDVDGAGR
SYRLYKPVGLPSSAPLVVMLHGGFGSAKQAERSYGWDELADSEKFLVAYPDGYHRAWN
ANGGGCCGRPAREGVDDIGFVRAVVADIANNVSIDPARVYVTGMSNGAIMSYTLACNT
SIFAAIGVVSGTQLDPCQSPRPVSVIHIHGTADPLVRYHGGPGAGFARIDGPPVPDLN
AFWREVNRCGALDTTTEGPVTTSGATCADNRRVVLLTVDDAGHRWPSFATQTLWRFFA
AHFR"
gene 771484..773112
/gene="fadE8"
/locus_tag="Rv0672"
CDS 771484..773112
/codon_start=1
/transl_table=11
/gene="fadE8"
/locus_tag="Rv0672"
/product="Probable acyl-CoA dehydrogenase FadE8"
/note="Rv0672, (MTCI376.02c), len: 542 aa. Probable
fadE8,acyl-CoA dehydrogenase, highly similar to many e.g.
CAC33951.1|AL589708 putative acyl-CoA dehydrogenase from
Streptomyces coelicolor (557 aa); P33224|AIDB_ECOLI|B4187
aidb protein (acyl-CoA dehydrogenases family) from
Escherichia coli strain K12 (546 aa), FASTA scores: opt:
1369, E(): 0, (44.1% identity in 524 aa overlap); etc.
Also similar to several other M. tuberculosis proteins
e.g. Rv0154c|MTCI5.28c FASTA score: (26.3% identity in 342
aa overlap); etc. Contains acyl-CoA dehydrogenases
signature 2 (PS00073). Belongs to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0672"
/db_xref="EnsemblGenomes-Tr:CCP43415"
/db_xref="GOA:I6X9J0"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR041504"
/db_xref="UniProtKB/TrEMBL:I6X9J0"
/inference="protein motif:PROSITE:PS00073"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43415.1"
/translation="MSDTHVVTNQVPPLENYNPASSPVLIEALIQEGGQWGLDEVNEV
GAISASCQAQRWGELADRNRPILHTHDAYGYRVDEVEYDPAYHELMRTAITHGMHAAP
WADDRPGAHVVRAAKTSVWTVEPGHICPISMTYAVVPALRYNSELAAVYEPLLTSREY
DPELKPATTKAGITAGMSMTEKQGGSDVRAGTTQATPNADGSYSLTGHKWFTSAPMCD
IFLVLAQAPDGLSCFLLPRVLPDGTRNRMFLQRLKDKLGNHANASSEVEYDGAVAWLV
GEEGRGVPTIIEMVNLTRLDCALGSATSMRTGLTRAVHHAQHRKAFGAYLIDQPLMRN
VLADLAVEAEAATIVAMRMAGATDNAVRGNETEALLRRIGLAAAKYWVCKRSTAHAAE
ALECLGGNGYVEDSGMPRLYREAPLMGIWEGSGNVSALDTLRAMATRPACVEVLFDEL
ARSAGQDPRLDGHVERLRPQLGDLDTIGYRARKIAEDICLALQGSLLVRHGHPAVAEA
FLATRLGGQWGGAYGTMPAGLDLAPILERALVKG"
gene 773123..774061
/gene="echA4"
/locus_tag="Rv0673"
CDS 773123..774061
/codon_start=1
/transl_table=11
/gene="echA4"
/locus_tag="Rv0673"
/product="Possible enoyl-CoA hydratase EchA4 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv0673, (MTCI376.01c, MTV040.01), len: 312 aa.
Possible echA4, enoyl-CoA hydratase, showing similarity
with others e.g. NP_419216.1|NC_002696 enoyl-CoA
hydratase/isomerase family protein from Caulobacter
crescentus (256 aa); Q52995|ECHH_RHIME probable enoyl-CoA
hydratase from Sinorhizobium meliloti (257 aa), FASTA
scores: opt: 210, E(): 1.2e-06, (27.9% identity in 280 aa
overlap); etc. Also similar to other enoyl-CoA hydratases
from Mycobacterium tuberculosis e.g.
P95279|MTCY09F9.29|ECHA13|Rv1935c|MTCY09F9.29 enoyl-CoA
hydratase (318 aa), FASTA score: (27.1% identity in 280 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0673"
/db_xref="EnsemblGenomes-Tr:CCP43416"
/db_xref="GOA:I6Y8F2"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:I6Y8F2"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43416.1"
/translation="MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPL
ELSALVERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDGKT
QAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGYCVAGGTDIALHADQ
VIAAADAKIGYPPTRVWGVPAAGLWAHRLGDQRAKRLLFTGDCITGAQAAEWGLAVEA
PEPADLDERTERLVARIAALPVNQLIMVKLALNSALLQQGVATSRMVSTVFDGAARHT
PEGHAFVADAVEHGFRDAVRRRDEPFGDYGRQASRV"
gene 774064..774786
/locus_tag="Rv0674"
CDS 774064..774786
/codon_start=1
/transl_table=11
/locus_tag="Rv0674"
/product="Conserved hypothetical protein"
/note="Rv0674, (MTV040.02), len: 240 aa. Conserved
hypothetical protein, highly similar to AC13063.1|AL445503
conserved hypothetical protein from Streptomyces
coelicolor (268 aa); and similar to NP_438100.1|NC_003078
putative regulator of phenylacetic acid degradation ArsR
family protein from Sinorhizobium meliloti (306 aa) and
other proteins e.g. AB011837|AB011837_13 hypothetical
protein from Bacillus halodurans (298 aa), FASTA scores:
opt: 148,E(): 0.0081, (25.1% identity in 235 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv0674"
/db_xref="EnsemblGenomes-Tr:CCP43417"
/db_xref="InterPro:IPR012906"
/db_xref="InterPro:IPR013225"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:I6WZ26"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43417.1"
/translation="MPAMTARSVVLSVLLGAHPAWATASELIQLTADFGIKETTLRVA
LTRMVGAGDLVRSADGYRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDAR
TRAALRTCMHHKRFGELREGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLW
DLSGWTEAGHRLLGDMAAATDMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRA
AYHDFATAMAKRRDATQLLEVT"
gene 774783..775574
/gene="echA5"
/locus_tag="Rv0675"
CDS 774783..775574
/codon_start=1
/transl_table=11
/gene="echA5"
/locus_tag="Rv0675"
/product="Probable enoyl-CoA hydratase EchA5 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv0675, (MTV040.03), len: 263 aa. Probable
echA5,enoyl-CoA hydratase, similar to several e.g.
NP_252116.1|NC_002516 probable enoyl
CoA-hydratase/isomerase from Pseudomonas aeruginosa (256
aa); Q20376 protein similar to enoyl-CoA hydratase from
Caenorhabditis elegans (258 aa), FASTA scores: opt:
697,E(): 0, (47.3% identity in 245 aa overlap); etc. Also
similar to others from Mycobacterium tuberculosis e.g.
Z92669|MTCY8D5_17 (262 aa), FASTA scores: opt: 493, E():
3.6e-25, (39.1% identity in 243 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0675"
/db_xref="EnsemblGenomes-Tr:CCP43418"
/db_xref="GOA:I6Y4E8"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="PDB:4Z0M"
/db_xref="UniProtKB/TrEMBL:I6Y4E8"
/inference="protein motif:PROSITE:PS00166"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43418.1"
/translation="MSDLVRVERKGRVTTVILNRPASRNAVNGPTAAALCAAFEQFDR
DDAASVAVLWGAGGTFCAGADLKAFGTPEANSVHRTGPGPMGPSRMMLSKPVIAAVSG
YAVAGGLELALWCDLRVAEEDAVFGVFCRRWGVPLIDGGTVRLPRLIGHSRAMDMILT
GRGVPADEALAMGLANRVVPKGQARQAAEELAAQLAALPQQCLRSDRLSALHQWGLPE
SAALDLEFASIARVAGEALEGARRFAAGAGRHGAPAPRAEQGDTL"
gene complement(775586..778480)
/gene="mmpL5"
/locus_tag="Rv0676c"
CDS complement(775586..778480)
/codon_start=1
/transl_table=11
/gene="mmpL5"
/locus_tag="Rv0676c"
/product="Probable conserved transmembrane transport
protein MmpL5"
/note="Rv0676c, (MTV040.04c), len: 964 aa. Probable
mmpL5,conserved transmembrane transport protein (see
Tekaia et al., 1999), member of RND superfamily, highly
similar to other Mycobacterial proteins e.g. MTV037_14,
MTCY98_8,MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6,
MTV005_19,etc. Also similar to other Mycobacterial mmpl
proteins e.g. P54881|MML4_MYCLE putative membrane protein
MMPL4 from Mycobacterium leprae (959 aa), FASTA scores:
opt: 3991,E(): 0, (62.8% identity in 933 aa overlap); etc.
Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv0676c"
/db_xref="EnsemblGenomes-Tr:CCP43419"
/db_xref="GOA:P9WJV1"
/db_xref="InterPro:IPR004707"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJV1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43419.1"
/translation="MIVQRTAAPTGSVPPDRHAARPFIPRMIRTFAVPIILGWLVTIA
VLNVTVPQLETVGQIQAVSMSPDAAPSMISMKHIGKVFEEGDSDSAAMIVLEGQRPLG
DAAHAFYDQMIGRLQADTTHVQSLQDFWGDPLTATGAQSSDGKAAYVQVKLAGNQGES
LANESVEAVKTIVERLAPPPGVKVYVTGSAALVADQQQAGDRSLQVIEAVTFTVIIVM
LLLVYRSIITSAIMLTMVVLGLLATRGGVAFLGFHRIIGLSTFATNLLVVLAIAAATD
YAIFLIGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQT
LGVPLAIGMVIVVAAALTLGPAIIAVTSRFGKLLEPKRMARVRGWRKVGAAIVRWPGP
ILVGAVALALVGLLTLPGYRTNYNDRNYLPADLPANEGYAAAERHFSQARMNPEVLMV
ESDHDMRNSADFLVINKIAKAIFAVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQ
KLTEKYNQDLTARMLEQVNDIQSNIDQMERMHSLTQQMADVTHEMVIQMTGMVVDVEE
LRNHIADFDDFFRPIRSYFYWEKHCYDIPVCWSLRSVFDTLDGIDVMTEDINNLLPLM
QRLDTLMPQLTAMMPEMIQTMKSMKAQMLSMHSTQEGLQDQMAAMQEDSAAMGEAFDA
SRNDDSFYLPPEVFDNPDFQRGLEQFLSPDGHAVRFIISHEGDPMSQAGIARIAKIKT
AAKEAIKGTPLEGSAIYLGGTAAMFKDLSDGNTYDLMIAGISALCLIFIIMLITTRSV
VAAAVIVGTVVLSLGASFGLSVLIWQHILGIELHWLVLAMAVIILLAVGADYNLLLVA
RLKEEIHAGINTGIIRAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGL
LFDTLIVRSFMTPSIAALLGKWFWWPQVVRQRPIPQPWPSPASARTFALV"
gene complement(778477..778905)
/gene="mmpS5"
/locus_tag="Rv0677c"
CDS complement(778477..778905)
/codon_start=1
/transl_table=11
/gene="mmpS5"
/locus_tag="Rv0677c"
/product="Possible conserved membrane protein MmpS5"
/note="Rv0677c, (MTV040.05c), len: 142 aa. Possible
mmpS5,conserved membrane protein (see Tekaia et al.,
1999),highly similar to other Mycobacterial proteins e.g.
P54880|MMS4_MYCLE putative membrane protein from
Mycobacterium leprae (154 aa), FASTA scores: opt: 443,
E(): 1.4e-23, (47.1% identity in 155 aa overlap); etc.
Also similar to others from Mycobacterium tuberculosis.
Belongs to the MmpS family. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0677c"
/db_xref="EnsemblGenomes-Tr:CCP43420"
/db_xref="GOA:P9WJS7"
/db_xref="InterPro:IPR008693"
/db_xref="InterPro:IPR038468"
/db_xref="UniProtKB/Swiss-Prot:P9WJS7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43420.1"
/translation="MIGTLKRAWIPLLILVVVAIAGFTVQRIRTFFGSEGILVTPKVF
ADDPEPFDPKVVEYEVSGSGSYVNINYLDLDAKPQRIDGAALPWSLTLKTTAPSAAPN
ILAQGDGTSITCRITVDGEVKDERTATGVDALTYCFVKSA"
gene 778990..779487
/locus_tag="Rv0678"
CDS 778990..779487
/codon_start=1
/transl_table=11
/locus_tag="Rv0678"
/product="Conserved protein"
/note="Rv0678, (MTV040.06), len: 165 aa. Conserved
protein,showing weak similarity with AL049754|SCH10_10
hypothetical protein from Streptomyces coelicolor (152
aa), FASTA scores: opt: 149, E(): 0.0018, (22.9% identity
in 140 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0678"
/db_xref="EnsemblGenomes-Tr:CCP43421"
/db_xref="GOA:I6Y8F7"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:4NB5"
/db_xref="UniProtKB/Swiss-Prot:I6Y8F7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43421.1"
/translation="MSVNDGVDQMGAEPDIMEFVEQMGGYFESRSLTRLAGRLLGWLL
VCDPERQSSEELATALAASSGGISTNARMLIQFGFIERLAVAGDRRTYFRLRPNAFAA
GERERIRAMAELQDLADVGLRALGDAPPQRSRRLREMRDLLAYMENVVSDALGRYSQR
TGEDD"
gene complement(779543..780040)
/locus_tag="Rv0679c"
CDS complement(779543..780040)
/codon_start=1
/transl_table=11
/locus_tag="Rv0679c"
/product="Conserved threonine rich protein"
/note="Rv0679c, (MTV040.07c), len: 165 aa. Conserved
Thr-rich protein, similar in part to neighboring ORF
Rv0680c (124 aa), FASTA score: (35.1% identity in 131 aa
overlap); and Rv0314c (220 aa). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0679c"
/db_xref="EnsemblGenomes-Tr:CCP43422"
/db_xref="InterPro:IPR021417"
/db_xref="UniProtKB/TrEMBL:I6WZ30"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43422.1"
/translation="MVEKPLRADRATHSRLATFALALAAAALPLAGCSSTANPPAATT
TPATATTTTATSGPTAAPTVTTGESTTASIQIGDMLTYGSIGTTATLDCADGKSLNVA
GSDNTLTVNGTCETVTVGGANNKIAFDRIDERLVVVGLDNTVTYKNGDPTIDNLGAGN
RINKE"
gene complement(780042..780416)
/locus_tag="Rv0680c"
CDS complement(780042..780416)
/codon_start=1
/transl_table=11
/locus_tag="Rv0680c"
/product="Probable conserved transmembrane protein"
/note="Rv0680c, (MTV040.08c), len: 124 aa. Possible
conserved transmembrane protein, showing similarity with
C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved
hypothetical protein from Mycobacterium tuberculosis (220
aa), FASTA scores: opt: 175, E(): 2.2e-05, (31.4% identity
in 102 aa overlap). Also some similarity to upstream ORF
Rv0679c|MTV040.07c conserved hypothetical threonine rich
protein (124 aa), FASTA score: (35.1% identity in 131 aa
overlap). Contains possible membrane spanning regions."
/db_xref="EnsemblGenomes-Gn:Rv0680c"
/db_xref="EnsemblGenomes-Tr:CCP43423"
/db_xref="GOA:I6Y4F1"
/db_xref="InterPro:IPR021417"
/db_xref="UniProtKB/TrEMBL:I6Y4F1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43423.1"
/translation="MKWNTVAASLAAGVITIAVALAAPPPAAHAKNGDTHVTGQGIER
TLDCNESTLLVNGTQNIVTALGTCWAVTVMGSSNTVVADTIINDITVYGWDETVFFRN
GDPFIWDRGRELGMVNRLQRVG"
gene 780721..781311
/locus_tag="Rv0681"
CDS 780721..781311
/codon_start=1
/transl_table=11
/locus_tag="Rv0681"
/product="Probable transcriptional regulatory protein
(possibly TetR-family)"
/note="Rv0681, (MTV040.09), len: 196 aa. Probable
transcription regulator, TetR family, similar to others
and especially many tetracycline repressors e.g. T34657
probable transcription regulator from Streptomyces
coelicolor (189 aa);
AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator
from Bacillus subtilis (191 aa), FASTA scores: opt:
213,E(): 1.6e-07, (28.8% identity in 153 aa overlap);
P09164|TER4_ECOLI tetracycline repressor protein from
Escherichia coli (217 aa), FASTA scores: opt: 145, E():
0.0068, (39.0% identity in 59 aa overlap); etc. Contains
helix-turn-helix motif at aa 28-49 (Score 1020, +2.66
SD)."
/db_xref="EnsemblGenomes-Gn:Rv0681"
/db_xref="EnsemblGenomes-Tr:CCP43424"
/db_xref="GOA:O53789"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR025996"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O53789"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43424.1"
/translation="MARPAKLSRESIVEGALTFLDREGWDSLTINALATQLGTKGPSL
YNHVDSLEDLRRAVRIRVIDDIITMLNRVGAGRARDDAVLVMAGAYRSYAHHHPGRYS
AFTRMPLGGDDPEYTAATRGAAAPVIAVLSSYGLDGEQAFYAALEFWSALHGFVLLEM
TGVMDDIDTDAVFTDMVLRLAAGMERRTTHGGTAST"
gene 781560..781934
/gene="rpsL"
/locus_tag="Rv0682"
CDS 781560..781934
/codon_start=1
/transl_table=11
/gene="rpsL"
/locus_tag="Rv0682"
/product="30S ribosomal protein S12 RpsL"
/note="Rv0682, (MTV040.10), len: 124 aa. rpsL, 30S
ribosomal protein S12 (see citations below), equivalent to
others from Mycobacteria e.g. P41195|RS12_MYCSM 30S
ribosomal protein S12 from Mycobacterium smegmatis (124
aa); P51999|RS12_MYCAV 30S ribosomal protein S12 from
Mycobacterium avium (124 aa); etc. Also highly similar to
others from other organisms e.g. P97222|RS12_STRCO 30S
ribosomal protein S12 from Streptomyces
roseosporus,lividans and coelicolor (123 aa); etc.
Contains PS00055 Ribosomal protein S12 signature. Belongs
to the S12P family of ribosomal proteins. Nucleotide
position 781922 in the genome sequence has been corrected,
A:G resulting in K121K."
/db_xref="EnsemblGenomes-Gn:Rv0682"
/db_xref="EnsemblGenomes-Tr:CCP43425"
/db_xref="GOA:P9WH63"
/db_xref="InterPro:IPR005679"
/db_xref="InterPro:IPR006032"
/db_xref="InterPro:IPR012340"
/db_xref="UniProtKB/Swiss-Prot:P9WH63"
/inference="protein motif:PROSITE:PS00055"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43425.1"
/translation="MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKK
PNSALRKVARVKLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSL
DTQGVKNRKQARSRYGAKKEKG"
gene 781934..782404
/gene="rpsG"
/locus_tag="Rv0683"
CDS 781934..782404
/codon_start=1
/transl_table=11
/gene="rpsG"
/locus_tag="Rv0683"
/product="30S ribosomal protein S7 RpsG"
/note="Rv0683, (MTV040.11), len: 156 aa. rpsG, 30S
ribosomal protein S7 (see citation below), equivalent to
others from Mycobacteria e.g. P41193|RS7_MYCSM 30S
ribosomal protein S7 from Mycobacterium smegmatis (156
aa),FASTA scores: opt: 986, E(): 0, (96.2% identity in 156
aa overlap); Q53539|RS7_MYCBO 30S ribosomal protein S7
from Mycobacterium bovis (156 aa); etc. Also highly
similar to others e.g. Q9L0K4|RS7_STRCO 30S ribosomal
protein S7 from Streptomyces coelicolor (156 aa); etc.
Contains PS00052 Ribosomal protein S7 signature. Belongs
to the S7P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0683"
/db_xref="EnsemblGenomes-Tr:CCP43426"
/db_xref="GOA:P9WH29"
/db_xref="InterPro:IPR000235"
/db_xref="InterPro:IPR005717"
/db_xref="InterPro:IPR020606"
/db_xref="InterPro:IPR023798"
/db_xref="InterPro:IPR036823"
/db_xref="PDB:6JMK"
/db_xref="UniProtKB/Swiss-Prot:P9WH29"
/inference="protein motif:PROSITE:PS00052"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43426.1"
/translation="MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLKGKKSLAERIVY
GALEQARDKTGTDPVITLKRALDNVKPALEVRSRRVGGATYQVPVEVRPDRSTTLALR
WLVGYSRQRREKTMIERLANEILDASNGLGASVKRREDTHKMAEANRAFAHYRW"
gene 782485..784590
/gene="fusA1"
/gene_synonym="fusA"
/locus_tag="Rv0684"
CDS 782485..784590
/codon_start=1
/transl_table=11
/gene="fusA1"
/gene_synonym="fusA"
/locus_tag="Rv0684"
/product="Probable elongation factor G FusA1 (EF-G)"
/note="Rv0684, (MTV040.12, MTCY210.01), len: 701 aa.
Probable fusA1, elongation factor G, equivalent to
P30767|EFG_MYCLE|S31150 translation elongation factor EF-G
from Mycobacterium leprae (701 aa), FASTA scores: opt:
2521, E(): 0, (88.2% identity in 432 aa overlap). Also
highly similar to others e.g. CAB81852.1|AL161691
elongation factor G from Streptomyces coelicolor (708 aa);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop) and PS00301 GTP-binding elongation factors
signature. Belongs to the GTP-binding elongation factor
family,EF-G/EF-2 subfamily. Note that previously known as
fusA."
/db_xref="EnsemblGenomes-Gn:Rv0684"
/db_xref="EnsemblGenomes-Tr:CCP43427"
/db_xref="GOA:P9WNM7"
/db_xref="InterPro:IPR000640"
/db_xref="InterPro:IPR000795"
/db_xref="InterPro:IPR004161"
/db_xref="InterPro:IPR004540"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR005517"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR009022"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031157"
/db_xref="InterPro:IPR035647"
/db_xref="InterPro:IPR035649"
/db_xref="InterPro:IPR041095"
/db_xref="UniProtKB/Swiss-Prot:P9WNM7"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00301"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43427.1"
/translation="MAQKDVLTDLSRVRNFGIMAHIDAGKTTTTERILYYTGINYKIG
EVHDGAATMDWMEQEQERGITITSAATTTFWKDNQLNIIDTPGHVDFTVEVERNLRVL
DGAVAVFDGKEGVEPQSEQVWRQADKYDVPRICFVNKMDKIGADFYFSVRTMGERLGA
NAVPIQLPVGAEADFEGVVDLVEMNAKVWRGETKLGETYDTVEIPADLAEQAEEYRTK
LLEVVAESDEHLLEKYLGGEELTVDEIKGAIRKLTIASEIYPVLCGSAFKNKGVQPML
DAVVDYLPSPLDVPPAIGHAPAKEDEEVVRKATTDEPFAALAFKIATHPFFGKLTYIR
VYSGTVESGSQVINATKGKKERLGKLFQMHSNKENPVDRASAGHIYAVIGLKDTTTGD
TLSDPNQQIVLESMTFPDPVIEVAIEPKTKSDQEKLSLSIQKLAEEDPTFKVHLDSET
GQTVIGGMGELHLDILVDRMRREFKVEANVGKPQVAYKETIKRLVQNVEYTHKKQTGG
SGQFAKVIINLEPFTGEEGATYEFESKVTGGRIPREYIPSVDAGAQDAMQYGVLAGYP
LVNLKVTLLDGAYHEVDSSEMAFKIAGSQVLKKAAALAQPVILEPIMAVEVTTPEDYM
GDVIGDLNSRRGQIQAMEERAGARVVRAHVPLSEMFGYVGDLRSKTQGRANYSMVFDS
YSEVPANVSKEIIAKATGE"
gene 784821..786011
/gene="tuf"
/locus_tag="Rv0685"
CDS 784821..786011
/codon_start=1
/transl_table=11
/gene="tuf"
/locus_tag="Rv0685"
/product="Probable iron-regulated elongation factor TU Tuf
(EF-TU)"
/note="Rv0685, (MTCY210.02), len: 396 aa. Probable
tuf,iron-regulated elongation factor EF-Tu, equivalent to
JC2262 translation elongation factor Tu from Mycobacterium
leprae (396 aa). Also highly similar to others e.g.
P42439|EFTU_CORGL elongation factor TU (EF-TU) from
Corynebacterium glutamicum (396 aa); etc. Contains PS00017
ATP/GTP-binding site motif A, and PS00301 GTP-binding
elongation factors signature. Belongs to the GTP-binding
elongation factor family, EF-TU/EF-1A subfamily. Predicted
possible vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0685"
/db_xref="EnsemblGenomes-Tr:CCP43428"
/db_xref="GOA:P9WNN1"
/db_xref="InterPro:IPR000795"
/db_xref="InterPro:IPR004160"
/db_xref="InterPro:IPR004161"
/db_xref="InterPro:IPR004541"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR009001"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031157"
/db_xref="InterPro:IPR033720"
/db_xref="InterPro:IPR041709"
/db_xref="UniProtKB/Swiss-Prot:P9WNN1"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00301"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43428.1"
/translation="MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLN
ETKAFDQIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMD
GAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELL
AAQEFDEDAPVVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVED
VFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDN
VGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFY
FRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVT
KIIK"
gene 786149..786946
/locus_tag="Rv0686"
CDS 786149..786946
/codon_start=1
/transl_table=11
/locus_tag="Rv0686"
/product="Probable membrane protein"
/note="Rv0686, (MTCY210.03), len: 265 aa. Probable
membrane protein, with hydrophobic N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0686"
/db_xref="EnsemblGenomes-Tr:CCP43429"
/db_xref="GOA:I6XVZ6"
/db_xref="UniProtKB/TrEMBL:I6XVZ6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43429.1"
/translation="MLARYIKMQLLVLLCGGLVGPIFLVVYFTLGLGSLMSWMFYVGL
IITVADVLVALALTNYGAKTAAKTAALERSGVLALAQITGLSETGTRINDQPLVKVHL
HISGPGITPFDTEDRVIASVTRLGNLTARKLVVLVNPATQQYLIDWERSALVNGLVPA
QFTVAEDNKTYDLSGQTGPLMEILQILKANNVPLNRMVDIRSNPALRQQVQAVVRRAA
ERQAPAAEPASQGSIAERLAELESLRASGAVNAAEYESKRAQIISEI"
gene 787099..787926
/locus_tag="Rv0687"
CDS 787099..787926
/codon_start=1
/transl_table=11
/locus_tag="Rv0687"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv0687, (MTCY210.04), len: 275 aa. Probable
short-chain dehydrogenase/reductase, highly similar to
various dehydrogenases (generally SDR family) e.g.
U17129|RSU17129_7 short-chain dehydrogenase from
Rhodococcus erythropolis (275 aa), FASTA scores: opt:
1112,E(): 0, (61.2% identity in 268 aa overlap);
MMU34072_2 steroid dehydrogenase from Musmus culus (260
aa), FASTA scores: opt: 390, E(): 2.2e-17, (34.1% identity
in 267 aa overlap); etc. Also similar to
MTV002_16|O33292|Rv2750 dehydrogenase from Mycobacterium
tuberculosis (272 aa). Contains PS00061 Short-chain
alcohol dehydrogenase family signature."
/db_xref="EnsemblGenomes-Gn:Rv0687"
/db_xref="EnsemblGenomes-Tr:CCP43430"
/db_xref="GOA:P9WGS7"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR023985"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGS7"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43430.1"
/translation="MSARGGSLHGRVAFVTGAARAQGRSHAVRLAREGADIVALDICA
PVSGSVTYPPATSEDLGETVRAVEAEGRKVLAREVDIRDDAELRRLVADGVEQFGRLD
IVVANAGVLGWGRLWELTDEQWETVIGVNLTGTWRTLRATVPAMIDAGNGGSIVVVSS
SAGLKATPGNGHYAASKHALVALTNTLAIELGEFGIRVNSIHPYSVDTPMIEPEAMIQ
TFAKHPGYVHSFPPMPLQPKGFMTPDEISDVVVWLAGDGSGALSGNQIPVDKGALKY"
gene 787940..789160
/locus_tag="Rv0688"
CDS 787940..789160
/codon_start=1
/transl_table=11
/locus_tag="Rv0688"
/product="Putative ferredoxin reductase"
/note="Rv0688, (MTCY210.05), len: 406 aa. Putative
ferredoxin reductase, highly similar to others e.g.
BAB55881.1|AB054975 ferredoxin reductase from Terrabacter
sp. DBF63 (410 aa); CAC04223.1|AL391515 putative
ferredoxin reductase from Streptomyces coelicolor (420
aa); PPU24215_8|Q51973 P-cumate dioxygenase ferredoxin
reductase subunit from Pseudomonas putida (402 aa), FASTA
scores: opt: 738, E(): 0, (38.8% identity in 330 aa
overlap); etc. Also similar to Rv0253 and Rv1869c from
Mycobacterium tuberculosis. Could belong to the bacterial
type ferredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv0688"
/db_xref="EnsemblGenomes-Tr:CCP43431"
/db_xref="GOA:P95034"
/db_xref="InterPro:IPR016156"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR028202"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:P95034"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43431.1"
/translation="MNAHVTSREGVNEFDDGIVIVGGGLAAARTAEQLRRAGYSGRLT
IVSDEVHLPYDRPPLSKEVLRSEVDDVALKPREFYDEKDIALRLGSAAVSLDTGEQTV
TLADGTVLGYDELVIATGLVPRRIPSLPDLDGIRVLRSFDESMALRKHASAARHAVVV
GAGFIGCEVAASLRGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRDEGVDVRTGVT
VAEVRGKGHVDAVVLTDGTELPADLVVVGIGSTPATEWLEGSGVEVDNGVICDKAGRT
SAPNVWALGDVASWRDPMGHQARVEHWSNVADQARVVVPAMLGTDVPTGVVVPYFWSD
QYDVKIQCLGEPHATDVVHLVEDDGRKFLAYYERDGVLVGVVGGGMAGKVMKVRGKIA
AGAPIAEVLDQTQA"
gene complement(789157..789411)
/locus_tag="Rv0689c"
CDS complement(789157..789411)
/codon_start=1
/transl_table=11
/locus_tag="Rv0689c"
/product="Hypothetical protein"
/note="Rv0689c, (MTCY210.06c), len: 84 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0689c"
/db_xref="EnsemblGenomes-Tr:CCP43432"
/db_xref="UniProtKB/TrEMBL:I6WZ39"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43432.1"
/translation="MLGWTVKPGRVADGWQAPGVHLMARCSGPQPASERRADMDGGDI
DAAVARVRAAGALAEPSRQPDDMSAECADDQGARCHLGQL"
gene complement(790024..791073)
/locus_tag="Rv0690c"
CDS complement(790024..791073)
/codon_start=1
/transl_table=11
/locus_tag="Rv0690c"
/product="Conserved hypothetical protein"
/note="Rv0690c, (MTCY210.07c), len: 349 aa. Conserved
hypothetical protein, showing similarity with
NP_386956.1|NC_003047 conserved hypothetical protein from
Sinorhizobium meliloti (358 aa); NP_356573.1|NC_003063
AGR_L_1570p from Agrobacterium tumefaciens (346 aa);
NP_421938.1|NC_002696 conserved hypothetical protein from
Caulobacter crescentus (370 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0690c"
/db_xref="EnsemblGenomes-Tr:CCP43433"
/db_xref="InterPro:IPR011200"
/db_xref="UniProtKB/TrEMBL:I6Y4G1"
/protein_id="CCP43433.1"
/translation="MTGTEHLVHTLRSQGRVCTSSGSPMYRELLELVAADVESGGVFA
SILADQKGAPEGQAVPLRLLGGLHRMVLDGRAPVLRRWYPSTGGTWQAEAAWPDIVRT
ATDQPESLRAALDRPPQTNEVGRSAALIGGLLIACLQFDLPIRLFEIGSSAGLNLRPD
RYRYRYLGGEWGLADSPVRIDNAWLGELPPTATVRIVERHGYDIAPIDVTSPDGELNA
LSYIWPDQTDRLERLRGAIAVARNIPADLHRQAAHAAVAGMTLTDDALTVLWHSITWQ
YLPADERAAIRAGIDALAAQADAHCPFVHLTLEPAHQRPGAQIKYLVRMRSWPGGHAR
VLGECHPHGPPVTWQ"
gene complement(791070..791666)
/locus_tag="Rv0691c"
CDS complement(791070..791666)
/codon_start=1
/transl_table=11
/locus_tag="Rv0691c"
/product="Probable transcriptional regulatory protein"
/note="Rv0691c, (MTCY210.08c), len: 198 aa. Probable
transcriptional regulator, highly similar to
AAC77476.1|U17129 unknown protein from Rhodococcus
erythropolis (185 aa); and showing similarity with
putative regulatory proteins eg
STMTCREP_1|TCMR_STRGA|P39885 tetracenomycin c
transcriptional repressor from Streptomyces glaucescens
(226 aa), FASTA scores: opt: 178,E(): 8.5e-06, (27.9%
identity in 201 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop) and probable
helix-turn helix motifs from aa 34-55 (Score 1100,+2.93
SD) and 151-172 (Score 1124, +3.02 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0691c"
/db_xref="EnsemblGenomes-Tr:CCP43434"
/db_xref="GOA:P9WMB7"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023851"
/db_xref="InterPro:IPR041347"
/db_xref="UniProtKB/Swiss-Prot:P9WMB7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43434.1"
/translation="MPHESRVGRRRSTTPHHISDVAIELFAAHGFTDVSVDDIARAAG
IARRTLFRYYASKNAIPWGDFSTHLAQLQGLLDNIDSRIQLRDALRAALLAFNTFDES
ETIRHRKRMRVILQTPELQAYSMTMYAGWREVIAKFVARRSGGKTTDFMPQTVAWTML
GVALSAYEHWLRDESVSLTEALGAAFDVVGAGLDRLNQ"
gene 791658..791846
/locus_tag="Rv0691A"
CDS 791658..791846
/codon_start=1
/transl_table=11
/locus_tag="Rv0691A"
/product="Mycofactocin precursor protein"
/note="Rv0691A, len: 62 aa. Mycofactocin precursor
protein."
/db_xref="EnsemblGenomes-Gn:Rv0691A"
/db_xref="EnsemblGenomes-Tr:CCP43435"
/db_xref="InterPro:IPR023988"
/db_xref="UniProtKB/Swiss-Prot:P9WJ81"
/protein_id="CCP43435.1"
/translation="MRHHIRPSISALDAILCPDRRIAVETCWRKAIQMDYETDTDTEL
VTETLVEEVSIDGMCGVY"
gene 791831..792160
/locus_tag="Rv0692"
CDS 791831..792160
/codon_start=1
/transl_table=11
/locus_tag="Rv0692"
/product="Conserved hypothetical protein"
/note="Rv0692, (MTCY210.09), len: 109 aa. Conserved
hypothetical protein, highly similar to
U17129|RSU17129_3|AAC77477.1 unknown protein from
Rhodococcus erythropolis (95 aa), FASTA scores: opt:
393,E(): 8.8e-22, (68.2% identity in 88 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0692"
/db_xref="EnsemblGenomes-Tr:CCP43436"
/db_xref="InterPro:IPR023850"
/db_xref="UniProtKB/Swiss-Prot:P95038"
/protein_id="CCP43436.1"
/translation="MWGLLTVPAPAQARRADSSEFDPDRGWRLHPQVAVRPEPFGALL
YHFGTRKLSFLKNRTILAVVQTLADYPDIRSACRGAGVDDCDQDPYLHALSVLAGSNM
LVPRQTT"
gene 792157..793332
/gene="pqqE"
/gene_synonym="pqqIII"
/locus_tag="Rv0693"
CDS 792157..793332
/codon_start=1
/transl_table=11
/gene="pqqE"
/gene_synonym="pqqIII"
/locus_tag="Rv0693"
/product="Probable coenzyme PQQ synthesis protein E PqqE
(coenzyme PQQ synthesis protein III)"
/note="Rv0693, (MTCY210.10), len: 391 aa. Probable pqqE
(alternate gene name: pqqIII), coenzyme PQQ synthesis
protein E, similar to others AE001109_9|O30258|PQQE
coenzyme PQQ synthesis protein from Archaeoglobus fulgidus
(375 aa), FASTA scores: E(): 1.6e-16, (28.1% identity in
377 aa overlap); PQQE_ACICA|P07782 coenzyme pqq synthesis
protein e from Acinetobacter calcoaceticus (384 aa), FASTA
scores: opt: 302, E(): 1.8e-12, (23.9% identity in 377 aa
overlap); etc. Also similar to C-terminus of heme
biosynthesis proteins e.g. O28270|AF2009 heme biosynthesis
protein (NIRJ-2) from Archaeoglobus fulgidus (468 aa).
Note that also highly similar to
U17129|RSU17129_4|AAC77478.1 unknown protein from
Rhodococcus erythropolis (405 aa),FASTA scores: opt: 1997,
E(): 0, (73.3% identity in 390 aa overlap). Could belong
to the MoaA / NifB / PqqE family."
/db_xref="EnsemblGenomes-Gn:Rv0693"
/db_xref="EnsemblGenomes-Tr:CCP43437"
/db_xref="GOA:P9WJ79"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR017200"
/db_xref="InterPro:IPR023885"
/db_xref="InterPro:IPR023913"
/db_xref="InterPro:IPR034391"
/db_xref="UniProtKB/Swiss-Prot:P9WJ79"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43437.1"
/translation="MTSPVPRLIEQFERGLDAPICLTWELTYACNLACVHCLSSSGKR
DPGELSTRQCKDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYATAHHVGVKFSTNG
VRITPEVATRLAATDYVDVQISLDGATAEVNDAIRGTGSFDMAVRALQNLAAAGFAGV
KISVVITRRNVAQLDEFATLASRYGATLRITRLRPSGRGTDVWADLHPTADQQVQLYD
WLVSKGERVLTGDSFFHLAPLGQSGALAGLNMCGAGRVVCLIDPVGDVYACPFAIHDH
FLAGNVLSDGGFQNVWKNSSLFRELREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPL
DGPDPECVQGHSEPALARERHLPRPRADHSRGRRVSKPVPLTLSMRPPKRPCNESPV"
gene 793335..794525
/gene="lldD1"
/locus_tag="Rv0694"
CDS 793335..794525
/codon_start=1
/transl_table=11
/gene="lldD1"
/locus_tag="Rv0694"
/product="Possible L-lactate dehydrogenase (cytochrome)
LldD1"
/note="Rv0694, (MTCY210.11), len: 396 aa. Possible
lldD1,L-lactate dehydrogenase (cytochrome), similar to
NP_302368.1|NC_002677 L-lactate dehydrogenase from
Mycobacterium leprae (414 aa). Also similar to others e.g.
NP_384560.1|NC_003047 putative L-lactate dehydrogenase
(cytochrome) protein from Sinorhizobium meliloti (403 aa);
NP_251072.1|NC_002516 L-lactate dehydrogenase from
Pseudomonas aeruginosa (383 aa); P33232|LLDD_ECOLI
L-lactate dehydrogenase (cytochrome) from Escherichia coli
strain K12 (396 aa), FASTA scores: opt: 697, E(): 0, (34.5
identity in 380 aa overlap); etc; and also similar to
other oxidoreductases. Note that also highly similar to
RSU17129_5|AAC77479.1|U17129 unknown protein from
Rhodococcus erythropolis (392 aa), FASTA scores: opt:
2006,E(): 0, (74.1% identity in 386 aa overlap). Also
similar to lldD2|Rv1872c|MTCY180.46|MTCY359.01 possible
L-lactate dehydrogenase (cytochrome) from Mycobacterium
tuberculosis (414 aa). Belongs to the FMN-dependent
alpha-hydroxy acid dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0694"
/db_xref="EnsemblGenomes-Tr:CCP43438"
/db_xref="GOA:P9WND7"
/db_xref="InterPro:IPR000262"
/db_xref="InterPro:IPR012133"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR023989"
/db_xref="InterPro:IPR037396"
/db_xref="UniProtKB/Swiss-Prot:P9WND7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43438.1"
/translation="MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAA
FSELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARG
TVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWT
FSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEP
GPPFFAAYGEWMATPPPTWEDIGWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVS
NHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRA
YLWGLAANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPS
RRDV"
gene 794715..795470
/locus_tag="Rv0695"
CDS 794715..795470
/codon_start=1
/transl_table=11
/locus_tag="Rv0695"
/product="Conserved hypothetical protein"
/note="Rv0695, (MTCY210.12), len: 251 aa. Conserved
hypothetical protein, similar to many creatinine
amidohydrolases or hypothetical proteins e.g.
NP_443048.1|NC_000911 creatinine amidohydrolase from
Synechococcus sp. PCC 6803 (273 aa); NP_466169.1|NC_003210
protein similar to creatinine amidohydrolase from Listeria
monocytogenes (249 aa); T35153|SC5A7.04c hypothetical
protein from Streptomyces coelicolor (273 aa); etc. Note
that highly similar to RSU17129_10|AAC77474.1|U17129
unknown protein from Rhodococcus erythropolis (230
aa),FASTA scores: opt: 693, E(): 0, (55.7% identity in 237
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0695"
/db_xref="EnsemblGenomes-Tr:CCP43439"
/db_xref="GOA:P9WP59"
/db_xref="InterPro:IPR003785"
/db_xref="InterPro:IPR023871"
/db_xref="InterPro:IPR024087"
/db_xref="UniProtKB/Swiss-Prot:P9WP59"
/protein_id="CCP43439.1"
/translation="MNSSYHRRVPVVGELGSATSSQLPSTSPSIVIPLGSTEQHGPHL
PLDTDTRIATAVARTVTARLHAEDLPIAQEEWLMAPAIAYGASGEHQRFAGTISIGTE
ALTMLLVEYGRSAACWARRLVFVNGHGGNVGALTRAVGLLRAEGRDAGWCPCTCPGGD
PHAGHTETSVLLHLSPADVRTERWRAGNRAPLPVLLPSMRRGGVAAVSETGVLGDPTT
ATAAEGRRIFAAMVDDCVRRVARWMPQPDGMLT"
repeat_region 795467..795518
/note="52 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 795519..796931
/locus_tag="Rv0696"
CDS 795519..796931
/codon_start=1
/transl_table=11
/locus_tag="Rv0696"
/product="Probable membrane sugar transferase"
/note="Rv0696, (MTCY210.13), len: 470 aa. Probable
membrane sugar transferase, similar (except in N-terminus)
to NP_069157.1|NC_000917 glycosyl transferase from
Archaeoglobus fulgidus (324 aa); NP_279985.1|NC_002607
rhamnosyl transferase from Halobacterium sp. NRC-1 (299
aa); NP_059113.1|NM_017417 polypeptide
N-acetylgalactosaminyltransferase 8 from (637 aa). Note
that also highly similar to P46370|YTH1_RHOER hypothetical
55.3 KDA protein from Rhodococcus erythropolis (513
aa),FASTA scores: opt: 1514, E(): 0, (51.8% identity in
469 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0696"
/db_xref="EnsemblGenomes-Tr:CCP43440"
/db_xref="GOA:P9WMX1"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR023981"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WMX1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43440.1"
/translation="MTATRLPDGFAVQVDRRVRVLGDGSALLGGSPTRLLRLAPAARG
LLCDGRLKVRDEVSAELARILLDATVAHPRPPSGPSHRDVTVVIPVRNNASGLRRLVT
SLRGLRVIVVDDGSACPVESDDFVGAHCDIEVLHHPHSKGPAAARNTGLAACTTDFVA
FLDSDVTPRRGWLESLLGHFCDPTVALVAPRIVSLVEGENPVARYEALHSSLDLGQRE
APVLPHSTVSYVPSAAIVCRSSAIRDVGGFDETMHSGEDVDLCWRLIEAGARLRYEPI
ALVAHDHRTQLRDWIARKAFYGGSAAPLAVRHPDKTAPLVISGGALMAWILMSIGTGL
GRLASLVIAVLTGRRIARAMRCAETSFLDVLAVATRGLWAAALQLASAICRHYWPLAL
LAAILSRRCRRVVLIAAVVDGVVDWLRRREGADDDAEPIGPLTYLVLKRVDDLAYGAG
LWYGVVRERNIGALKPQIRT"
gene 796933..798372
/locus_tag="Rv0697"
CDS 796933..798372
/codon_start=1
/transl_table=11
/locus_tag="Rv0697"
/product="Probable dehydrogenase"
/note="Rv0697, (MTCY210.14, unknown), len: 479 aa.
Probable dehydrogenase, highly similar to
P30772|YTUR_MYCLE hypothetical 24 kDa protein from
Mycobacterium leprae (220 aa), FASTA scores: opt: 557,
E(): 1.7e-28, (46.2% identity in 223 aa overlap). Also
highly similar to P46371|YTH2_RHOER hypothetical 53.0 KDA
GMC-type oxidoreductase from Rhodococcus erythropolis (493
aa); and similar to many dehydrogenases e.g.
NP_250814.1|NC_002516 probable dehydrogenase from
Pseudomonas aeruginosa (545 aa); BAA13145.1|D86622 FAD
dependent L-sorbose dehydrogenase from Gluconobacter
oxydans (531 aa); etc. Also similar to Rv1279 conserved
hypothetical protein from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0697"
/db_xref="EnsemblGenomes-Tr:CCP43441"
/db_xref="GOA:I6Y8H4"
/db_xref="InterPro:IPR000172"
/db_xref="InterPro:IPR007867"
/db_xref="InterPro:IPR012132"
/db_xref="InterPro:IPR023978"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:I6Y8H4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43441.1"
/translation="MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLA
DPGLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAINGGYFC
RGLPSDFDRASIPGWAWSDVLEHFRAIETDLDFETPVHGRSGPIPVRRTHEMTGITES
FMAAAEDAGFAWIADLNDVGPEMPSGVGAVPLNIVNGVRTSSAVGYLMPALGRPNLTL
LARTRAVRLRFSATTAVGVDAIGPGGPVSLSADRIVLCAGAIQSAHLLMLSGVGEEEV
LRSAGVKVLMALPVGMGCSDHPEWVMPTNWAVAVDRPVLEVLLSTHDGIEIRPYTGGF
VAMTGDGTAGHRDWPHIGVALMQPRARGRITLVSSDPQIPVRIEHRYDSEPADVAALR
QGSALAHELCGAATRIGPAVWATSQHLCGSAPMGTDDDPRAVVDPRCRVRGIENLWVI
DGSVLPSITSRGPHATIVMLGHRAAEFVQ"
gene 798833..799444
/locus_tag="Rv0698"
CDS 798833..799444
/codon_start=1
/transl_table=11
/locus_tag="Rv0698"
/product="Conserved hypothetical protein"
/note="Rv0698, (MTCY210.15), len: 203 aa. Conserved
hypothetical protein, highly similar to C-terminus of
Rv3639c|MTY15C10.12 conserved hypothetical protein from
Mycobacterium tuberculosis (188 aa), FASTA scores: E():
2.1e-07, (54.8% identity in 73 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0698"
/db_xref="EnsemblGenomes-Tr:CCP43442"
/db_xref="UniProtKB/TrEMBL:P95044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43442.1"
/translation="MGRRGNRRVHVDRVRLTGTERELRAENQSPPIFRPQNTLGDGAN
GLPLAVCTTTAHTCHTSHTHPSRWTPNPVPATKGVPAGLVQATFIIENLDPGNNDTPT
PPTPKLRLARKPGHHRRSEYDADSVLRRKDTSRRCVQADDVRCVQLVQDPRRGRVELG
GYRAELTVGRRAAVNCQRPQYGADGWPVRLGCGVGGAARGDQR"
gene 799629..799850
/locus_tag="Rv0699"
CDS 799629..799850
/codon_start=1
/transl_table=11
/locus_tag="Rv0699"
/product="Hypothetical protein"
/note="Rv0699, (MTCY210.17), len: 73 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0699"
/db_xref="EnsemblGenomes-Tr:CCP43443"
/db_xref="GOA:P95046"
/db_xref="UniProtKB/TrEMBL:P95046"
/protein_id="CCP43443.1"
/translation="MGDRRVDLLAAKDSEIRRSMGAVPVGAGSSQVATSWASDRCIRC
RAAILSADCANLARANSRGGLAVGGSAVS"
gene 800487..800792
/gene="rpsJ"
/gene_synonym="nusE"
/locus_tag="Rv0700"
CDS 800487..800792
/codon_start=1
/transl_table=11
/gene="rpsJ"
/gene_synonym="nusE"
/locus_tag="Rv0700"
/product="30S ribosomal protein S10 RpsJ (transcription
antitermination factor NusE)"
/note="Rv0700, (MTCY210.19), len: 101 aa. rpsJ (alternate
gene name: nusE), 30S ribosomal protein S10 (see Gopal et
al., 2001), equivalent to RS10_MYCLE P307653 30S ribosomal
protein S10 from Mycobacterium leprae (101 aa), FASTA
scores: opt: 645, E(): 0, (97.0% identity in 101 aa
overlap). Also highly similar to others e.g.
CAB82069.1|AL161803 30S ribosomal protein S10 from
Streptomyces coelicolor (102 aa); etc. Contains PS00361
Ribosomal protein S10 signature. Belongs to the S10P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0700"
/db_xref="EnsemblGenomes-Tr:CCP43444"
/db_xref="GOA:P9WH67"
/db_xref="InterPro:IPR001848"
/db_xref="InterPro:IPR018268"
/db_xref="InterPro:IPR027486"
/db_xref="InterPro:IPR036838"
/db_xref="UniProtKB/Swiss-Prot:P9WH67"
/inference="protein motif:PROSITE:PS00361"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43444.1"
/translation="MAGQKIRIRLKAYDHEAIDASARKIVETVVRTGASVVGPVPLPT
EKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKTVDALMRIDLPASVDVNIQ"
gene 800809..801462
/gene="rplC"
/locus_tag="Rv0701"
CDS 800809..801462
/codon_start=1
/transl_table=11
/gene="rplC"
/locus_tag="Rv0701"
/product="50S ribosomal protein L3 RplC"
/note="Rv0701, (MTCY210.20), len: 217 aa. rplC, 50S
ribosomal protein L3, equivalent to O06044|RL3_MYCBO 50S
ribosomal protein L3 from Mycobacterium bovis BCG (217
aa); and P30762|RL3_MYCLE 50S ribosomal protein L3 from
Mycobacterium leprae (217 aa). Also highly similar to
others e.g. CAB82070.1|AL161803 50S ribosomal protein L3
from Streptomyces coelicolor (214 aa); P52860|RL3_THETH
ribosomal protein l3 from Thermus aquaticus (206 aa),
FASTA scores: opt: 717, E(): 0, (55.2% identity in 210 aa
overlap); etc. Contains PS00474 Ribosomal protein L3
signature. Belongs to the L3P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv0701"
/db_xref="EnsemblGenomes-Tr:CCP43445"
/db_xref="GOA:P9WH87"
/db_xref="InterPro:IPR000597"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR019926"
/db_xref="InterPro:IPR019927"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH87"
/inference="protein motif:PROSITE:PS00474"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43445.1"
/translation="MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPER
DGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELT
AEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARV
FKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK"
gene 801462..802133
/gene="rplD"
/locus_tag="Rv0702"
CDS 801462..802133
/codon_start=1
/transl_table=11
/gene="rplD"
/locus_tag="Rv0702"
/product="50S ribosomal protein L4 RplD"
/note="Rv0702, (MTCY210.21), len: 223 aa. rplD, 50S
ribosomal protein L4, equivalent to O06045|RL4_MYCBO 50S
ribosomal protein L4 from Mycobacterium bovis BCG (223
aa); O06114|RL4_MYCSM 50S ribosomal protein L4 from
Mycobacterium smegmatis (215 aa); and MLCB2492_3 50S
ribosomal protein L4 from Mycobacterium leprae (230 aa).
Also highly similar to others e.g. CAB82071.1|AL161803 50S
ribosomal protein L4 from Streptomyces coelicolor (219
aa); P28601|RL4_BACST 50s ribosomal protein L4 from
Bacillus stearothermophilus (207 aa), FASTA scores: opt:
522, E(): 3.5e-26, (42.4% identity in 198 aa overlap);
etc. Belongs to the L4P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0702"
/db_xref="EnsemblGenomes-Tr:CCP43446"
/db_xref="GOA:P9WH85"
/db_xref="InterPro:IPR002136"
/db_xref="InterPro:IPR013005"
/db_xref="InterPro:IPR023574"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH85"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43446.1"
/translation="MAAQEQKTLKIDVKTPAGKVDGAIELPAELFDVPANIALMHQVV
TAQRAAARQGTHSTKTRGEVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVVHGPKPR
DYSQRTPKKMIAAALRGALSDRARNGRIHAITELVEGQNPSTKSARAFLASLTERKQV
LVVIGRSDEAGAKSVRNLPGVHILAPDQLNTYDVLRADDVVFSVEALNAYIAANTTTS
EEVSA"
gene 802133..802435
/gene="rplW"
/locus_tag="Rv0703"
CDS 802133..802435
/codon_start=1
/transl_table=11
/gene="rplW"
/locus_tag="Rv0703"
/product="50S ribosomal protein L23 RplW"
/note="Rv0703, (MTCY21.22), len: 100 aa. rplW, 50S
ribosomal protein L23, equivalent to O06046|RL23_MYCBO 50S
ribosomal protein L23 from Mycobacterium bovis BCG (100
aa); and MLCB2492_4 50S ribosomal protein L23 from
Mycobacterium leprae (100 aa). Also highly similar to
others e.g. CAB82072.1|AL161803 50S ribosomal protein L23
from Streptomyces coelicolor (139 aa) (N-terminus longer);
P04454|RL23_BACST 50s ribosomal protein L23 from Bacillus
stearothermophilus (95 aa), FASTA scores: opt: 275, E():
1.4e-13, (50.5% identity in 95 aa overlap); etc. Contains
PS00050 Ribosomal protein L23 signature. Belongs to the
L23P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0703"
/db_xref="EnsemblGenomes-Tr:CCP43447"
/db_xref="GOA:P9WHB9"
/db_xref="InterPro:IPR001014"
/db_xref="InterPro:IPR012677"
/db_xref="InterPro:IPR012678"
/db_xref="InterPro:IPR013025"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHB9"
/inference="protein motif:PROSITE:PS00050"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43447.1"
/translation="MATLADPRDIILAPVISEKSYGLLDDNVYTFLVRPDSNKTQIKI
AVEKIFAVKVASVNTANRQGKRKRTRTGYGKRKSTKRAIVTLAPGSRPIDLFGAPA"
repeat_region 802429..802477
/note="49 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 802528..803370
/gene="rplB"
/locus_tag="Rv0704"
CDS 802528..803370
/codon_start=1
/transl_table=11
/gene="rplB"
/locus_tag="Rv0704"
/product="50S ribosomal protein L2 RplB"
/note="Rv0704, (MTCY210.23), len: 280 aa. rplB, 50S
ribosomal protein L2, equivalent to O06047|RL2_MYCBO 50S
ribosomal protein L2 from Mycobacterium bovis BCG (280
aa); and MLCB2492_5M 50S ribosomal protein L2 from
Mycobacterium leprae (280 aa). Also highly similar to
others e.g. CAB82073.1|AL161803 50S ribosomal protein L2
from Streptomyces coelicolor (278 aa); P42919|RL2_BACSU
50s ribosomal protein l2 (bl2) from Bacillus subtilis (276
aa),FASTA scores: opt: 1179, E(): 0, (61.1% identity in
275 aa overlap); etc. Contains PS00467 Ribosomal protein
L2 signature. Belongs to the L2P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv0704"
/db_xref="EnsemblGenomes-Tr:CCP43448"
/db_xref="GOA:P9WHA5"
/db_xref="InterPro:IPR002171"
/db_xref="InterPro:IPR005880"
/db_xref="InterPro:IPR008991"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR014722"
/db_xref="InterPro:IPR014726"
/db_xref="InterPro:IPR022666"
/db_xref="InterPro:IPR022669"
/db_xref="InterPro:IPR022671"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHA5"
/inference="protein motif:PROSITE:PS00467"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43448.1"
/translation="MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGRGGRN
AHGRITTRHKGGGHKRAYRMIDFRRNDKDGVNAKVAHIEYDPNRTARIALLHYLDGEK
RYIIAPNGLSQGDVVESGANADIKPGNNLPLRNIPAGTLIHAVELRPGGGAKLARSAG
SSIQLLGKEASYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKR
PSVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRNANKSSNKFIVRRRRTGK
KHSR"
gene 803411..803692
/gene="rpsS"
/locus_tag="Rv0705"
CDS 803411..803692
/codon_start=1
/transl_table=11
/gene="rpsS"
/locus_tag="Rv0705"
/product="30S ribosomal protein S19 RpsS"
/note="Rv0705, (MTCY210.24), len: 93 aa. rpsS, 30S
ribosomal protein S19, equivalent to S36895 ribosomal
protein S19 from Mycobacterium bovis (93 aa), FASTA
scores: opt: 623, E(): 0, (98.9% identity in 93 aa
overlap); and NP_302261.1|NC_002677 30S ribosomal protein
S19 from Mycobacterium leprae (93 aa). Also highly similar
to others e.g. CAB82074.1|AL161803 30S ribosomal protein
S19 from Streptomyces coelicolor (93 aa); etc. Contains
PS00323 Ribosomal protein S19 signature. Belongs to the
S19P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0705"
/db_xref="EnsemblGenomes-Tr:CCP43449"
/db_xref="GOA:P9WH45"
/db_xref="InterPro:IPR002222"
/db_xref="InterPro:IPR005732"
/db_xref="InterPro:IPR020934"
/db_xref="InterPro:IPR023575"
/db_xref="UniProtKB/Swiss-Prot:P9WH45"
/inference="protein motif:PROSITE:PS00323"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43449.1"
/translation="MPRSLKKGPFVDEHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDF
IGHTFAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHIKDDRKSKRR"
gene 803689..804282
/gene="rplV"
/locus_tag="Rv0706"
CDS 803689..804282
/codon_start=1
/transl_table=11
/gene="rplV"
/locus_tag="Rv0706"
/product="50S ribosomal protein L22 RplV"
/note="Rv0706, (MTCY210.25), len: 197 aa. rplV, 50S
ribosomal protein L22, equivalent to O06115|RL22_MYCSM 50S
ribosomal protein L22 from Mycobacterium smegmatis (153
aa); MBS10OPER_7 50S ribosomal protein L22 from
Mycobacterium bovis BCG; and MLCB2492_7 50S ribosomal
protein L22 from Mycobacterium leprae (175 aa). Also
highly similar to others e.g. CAB82075.1|AL161803 50S
ribosomal protein L22 from Streptomyces coelicolor (125
aa); P42060|RL22_BACSU 50s ribosomal protein L22 from
Bacillus subtilis (113 aa), FASTA scores: opt: 368, E():
2.4e-13,(52.8% identity in 108 aa overlap); etc. Contains
PS00464 Ribosomal protein L22 signature, and contains
repetitive sequence at C-terminus. Belongs to the L22P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0706"
/db_xref="EnsemblGenomes-Tr:CCP43450"
/db_xref="GOA:P9WHC1"
/db_xref="InterPro:IPR001063"
/db_xref="InterPro:IPR005727"
/db_xref="InterPro:IPR018260"
/db_xref="InterPro:IPR036394"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHC1"
/inference="protein motif:PROSITE:PS00464"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43450.1"
/translation="MTAATKATEYPSAVAKARFVRVSPRKARRVIDLVRGRSVSDALD
ILRWAPQAASGPVAKVIASAAANAQNNGGLDPATLVVATVYADQGPTAKRIRPRAQGR
AFRIRRRTSHITVVVESRPAKDQRSAKSSRARRTEASKAASKVGATAPAKKAAAKAPA
KKAPASSGVKKTPAKKAPAKKAPAKASETSAAKGGSD"
gene 804282..805106
/gene="rpsC"
/locus_tag="Rv0707"
CDS 804282..805106
/codon_start=1
/transl_table=11
/gene="rpsC"
/locus_tag="Rv0707"
/product="30S ribosomal protein S3 RpsC"
/note="Rv0707, (MTCY210.26), len: 274 aa. rpsC, 30S
ribosomal protein S3, equivalent to
O06048|RS3_MYCBO|MBS10OPER_8 30S ribosomal protein S3 from
Mycobacterium bovis BCG (274 aa); and MLCB2492_8 30S
ribosomal protein S3 from Mycobacterium leprae (281 aa).
Also highly similar to others e.g. CAB82076.1|AL161803 30S
ribosomal protein S3 from Streptomyces coelicolor (277
aa); P21465|RS3_BACSU 30s ribosomal protein s3 (bs3) (bs2)
from Bacillus subtilis (217 aa), FASTA scores: opt: 794,
E(): 0,(52.8% identity in 212 aa overlap); etc. Belongs to
the S3P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0707"
/db_xref="EnsemblGenomes-Tr:CCP43451"
/db_xref="GOA:P9WH37"
/db_xref="InterPro:IPR001351"
/db_xref="InterPro:IPR004044"
/db_xref="InterPro:IPR004087"
/db_xref="InterPro:IPR005704"
/db_xref="InterPro:IPR009019"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR018280"
/db_xref="InterPro:IPR036419"
/db_xref="UniProtKB/Swiss-Prot:P9WH37"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43451.1"
/translation="MGQKINPHGFRLGITTDWKSRWYADKQYAEYVKEDVAIRRLLSS
GLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNI
LEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGA
EMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAAA
PAGADRPRRERPSGTRPRRSGASGTTATGTDAGRAAGGEEAAPDAAAPVEAQSTES"
gene 805110..805526
/gene="rplP"
/locus_tag="Rv0708"
CDS 805110..805526
/codon_start=1
/transl_table=11
/gene="rplP"
/locus_tag="Rv0708"
/product="50S ribosomal protein L16 RplP"
/note="Rv0708, (MTCY210.27), len: 138 aa. rplP, 50S
ribosomal protein L16, equivalent to
O06049|RL16_MYCBO|MBS10OPER_9 50S ribosomal protein L16
from Mycobacterium bovis BCG (138 aa); and MLCB2492_9 50S
ribosomal protein L16 from Mycobacterium leprae (138 aa).
Also highly similar to others e.g. CAB82077.1|AL161803 50S
ribosomal protein L16 from Streptomyces coelicolor (139
aa); P14577|RL16_BACSU 50s ribosomal protein l16 from
Bacillus subtilis (144 aa), FASTA scores: opt: 600, E():
0,(63.2% identity in 136 aa overlap); etc. Contains
PS00701 Ribosomal protein L16 signature 2. Belongs to the
L16P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0708"
/db_xref="EnsemblGenomes-Tr:CCP43452"
/db_xref="GOA:P9WHD5"
/db_xref="InterPro:IPR000114"
/db_xref="InterPro:IPR016180"
/db_xref="InterPro:IPR020798"
/db_xref="InterPro:IPR036920"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHD5"
/inference="protein motif:PROSITE:PS00701"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43452.1"
/translation="MLIPRKVKHRKQHHPRQRGIASGGTTVNFGDYGIQALEHAYVTN
RQIESARIAINRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRV
LFELSYPNEGVARAALTRAIHKLPIKARIITREEQF"
gene 805526..805759
/gene="rpmC"
/locus_tag="Rv0709"
CDS 805526..805759
/codon_start=1
/transl_table=11
/gene="rpmC"
/locus_tag="Rv0709"
/product="50S ribosomal protein L29 RpmC"
/note="Rv0709, (MTCY210.28), len: 77 aa. rpmC, 50S
ribosomal protein L29, equivalent to
O06050|RL29_MYCBO|MBS10OPER_10 50S ribosomal protein L29
from Mycobacterium bovis BCG (75 aa); and
O32989|RL29_MYCLE|MLCB2492_10 50S ribosomal protein L29
from Mycobacterium leprae (80 aa). Also highly similar to
others e.g. Q9L0D2|RL29_STRCO 50S ribosomal protein L29
from Streptomyces coelicolor (74 aa); P12873|RL29_BACSU
50s ribosomal protein l29 from Bacillus subtilis (66 aa),
FASTA scores: opt: 225, E(): 8.3e-11, (58.6% identity in
58 aa overlap); etc. Belongs to the L29P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0709"
/db_xref="EnsemblGenomes-Tr:CCP43453"
/db_xref="GOA:P9WHA7"
/db_xref="InterPro:IPR001854"
/db_xref="InterPro:IPR018254"
/db_xref="InterPro:IPR036049"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43453.1"
/translation="MAVGVSPGELRELTDEELAERLRESKEELFNLRFQMATGQLNNN
RRLRTVRQEIARIYTVLRERELGLATGPDGKES"
gene 805756..806166
/gene="rpsQ"
/locus_tag="Rv0710"
CDS 805756..806166
/codon_start=1
/transl_table=11
/gene="rpsQ"
/locus_tag="Rv0710"
/product="30S ribosomal protein S17 RpsQ"
/note="Rv0710, (MTCY210.29), len: 136 aa. rpsQ, 30S
ribosomal protein S17, equivalent to O06051|RS17_MYCBO
30S|MBS10OPER_11 30S ribosomal protein S17 from
Mycobacterium bovis BCG (136 aa); and MLCB2492_11 30S
ribosomal protein S17 from Mycobacterium leprae (126 aa).
Also highly similar to others e.g. CAB82079.1|AL161803 30S
ribosomal protein S17 from Streptomyces coelicolor (95
aa); P12874|RS17_BACSU 30s ribosomal protein s17 (bs 16)
from Bacillus subtilis (86 aa), FASTA scores: opt: 305,
E(): 1.6e-11, (60.5% identity in 81 aa overlap); etc.
Contains PS00056 Ribosomal protein S17 signature."
/db_xref="EnsemblGenomes-Gn:Rv0710"
/db_xref="EnsemblGenomes-Tr:CCP43454"
/db_xref="GOA:P9WH51"
/db_xref="InterPro:IPR000266"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR019979"
/db_xref="InterPro:IPR019984"
/db_xref="UniProtKB/Swiss-Prot:P9WH51"
/inference="protein motif:PROSITE:PS00056"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43454.1"
/translation="MMAEAKTGAKAAPRVAKAAKAAPKKAAPNDAEAIGAANAANVKG
PKHTPRTPKPRGRRKTRIGYVVSDKMQKTIVVELEDRMRHPLYGKIIRTTKKVKAHDE
DSVAGIGDRVSLMETRPLSATKRWRLVEILEKAK"
gene 806335..808698
/gene="atsA"
/locus_tag="Rv0711"
CDS 806335..808698
/codon_start=1
/transl_table=11
/gene="atsA"
/locus_tag="Rv0711"
/product="Possible arylsulfatase AtsA (aryl-sulfate
sulphohydrolase) (arylsulphatase)"
/note="Rv0711, (MTCY210.30), len: 787 aa. Possible
atsA,arylsulfatase, similar to others e.g.
P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa
(532 aa), FASTA scores: opt: 439, E(): 2.9e-21, (30.8%
identity in 552 aa overlap); etc. Also similar to other
hypothetical arylsulfatases from Mycobacterium
tuberculosis e.g. Rv3299c, Rv0663, etc. Contains PS00523
Sulfatases signature 1, and PS00149 Sulfatases signature
2. Belongs to the sulfatase family."
/db_xref="EnsemblGenomes-Gn:Rv0711"
/db_xref="EnsemblGenomes-Tr:CCP43455"
/db_xref="GOA:P95059"
/db_xref="InterPro:IPR000917"
/db_xref="InterPro:IPR017850"
/db_xref="InterPro:IPR024607"
/db_xref="UniProtKB/TrEMBL:P95059"
/inference="protein motif:PROSITE:PS00678"
/inference="protein motif:PROSITE:PS00523"
/inference="protein motif:PROSITE:PS00149"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43455.1"
/translation="MAPEATEAFNGTIELDIRDSEPDWGPYAAPVAPEHSPNILYLVW
DDVGIATWDCFGGLVEMPAMTRVAERGVRLSQFHTTALCSPTRASLLTGRNATTVGMA
TIEEFTDGFPNCNGRIPADTALLPEVLAEHGYNTYCVGKWHLTPLEESNMASTKRHWP
TSRGFERFYGFLGGETDQWYPDLVYDNHPVSPPGTPEGGYHLSKDIADKTIEFIRDAK
VIAPDKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYERYREIVLERQKALGIVPP
DTELSPINPYLDVPGPNGETWPLQDTVRPWDSLSDEEKKLFCRMAEVFAGFLSYTDAQ
IGRILDYLEESGQLDNTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVAESMKLFD
HLGGPQTYNHYPIGWAMAFNTPYKLFKRYASHEGGIADPAIISWPNGIAAHGEIRDNY
VNVSDITPTVYDLLGMTPPGTVKGIPQKPMDGVSFIAALADPAADTGKTTQFYTMLGT
RGIWHEGWFANTIHAATPAGWSNFNADRWELFHIAADRSQCHDLAAEHPDKLEELKAL
WFSEAAKYNGLPLADLNLLETMTRSRPYLVSERASYVYYPDCADVGIGAAVEIRGRSF
AVLADVTIDTTGAEGVLFKHGGAHGGHVLFVRDGRLHYVYNFLGERQQLVSSSGPVPS
GRHLLGVRYLRTGTVPNSHTPVGDLELFFDENLVGALTNVLTHPGTFGLAGAAISVGR
NGGSAVSSHYEAPFAFTGGTITQVTVDVSGRPFEDVESDLALAFSRD"
gene 808746..809645
/locus_tag="Rv0712"
CDS 808746..809645
/codon_start=1
/transl_table=11
/locus_tag="Rv0712"
/product="Conserved protein"
/note="Rv0712, (MTCY210.31), len: 299 aa. Conserved
protein, similar to others e.g. NP_106128.1|NC_002678
hypothetical protein from Mesorhizobium loti (372 aa);
D90901_33|P72841 hypothetical 48.1 kDa protein from
Synechocystis sp (410 aa), FASTA scores: E():
1.1e-07,(28.8% identity in 299 aa overlap); etc. Slight
similarity to carboxykinases. Similar to C-terminal part
of Rv3703c conserved hypothetical protein from
Mycobacterium tuberculosis (425 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0712"
/db_xref="EnsemblGenomes-Tr:CCP43456"
/db_xref="GOA:I6Y8I5"
/db_xref="InterPro:IPR005532"
/db_xref="InterPro:IPR016187"
/db_xref="InterPro:IPR042095"
/db_xref="UniProtKB/Swiss-Prot:I6Y8I5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43456.1"
/translation="MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTN
AQFAEFVSATGYVTVAEQPLDPGLYPGVDAADLCPGAMVFCPTAGPVDLRDWRQWWDW
VPGACWRHPFGRDSDIADRAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTT
ATYAWGDQEKPGGMLMANTWQGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVW
EWTTTEFYPHHRIDPPSTACCAPVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAAR
SPQSQDTATTHIGFRCVADPVSG"
gene 809946..810887
/locus_tag="Rv0713"
CDS 809946..810887
/codon_start=1
/transl_table=11
/locus_tag="Rv0713"
/product="Probable conserved transmembrane protein"
/note="Rv0713, (MTCY210.32), len: 313 aa. Probable
conserved transmembrane protein, similar to
Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis
(284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35.8%
identity in 282 aa overlap); MLCB2492_12|O32991
hypothetical 10.7 kDa protein from Mycobacterium leprae
(95 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0713"
/db_xref="EnsemblGenomes-Tr:CCP43457"
/db_xref="GOA:I6WZ58"
/db_xref="InterPro:IPR027948"
/db_xref="UniProtKB/TrEMBL:I6WZ58"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43457.1"
/translation="MAGSDPPTGGPASQAGSDAGASPEHKHMSRRKHLVLDVCIILGV
LIAYVFSLLGYDWLAHTPGPLPQPDVGTTDDTVVLIRFEELHTVANRLDVKVLVLPDD
SMIDHRLQVLTTDTSVRLYPENELGDLQYPVGKLPAQVATTIEAHGNPGAWPFDTYTT
DTVQADVLVGAGDNRQYVPARVEVTGSLEGWDISAVRVGESSQTSDRPDNVIITLKRA
KGPLVFDLGICLVLITLPTLALFVAIQMITGRRKFQPPFGTWYAAMLFAVVPLRTILP
GSPPAGAWIDRAVVIWVLIALAAAMVVYIVAWYRESD"
gene 811373..811741
/gene="rplN"
/locus_tag="Rv0714"
CDS 811373..811741
/codon_start=1
/transl_table=11
/gene="rplN"
/locus_tag="Rv0714"
/product="50S ribosomal protein L14 RplN"
/note="Rv0714, (MTCY210.33), len: 122 aa. rplN, 50S
ribosomal protein L14, equivalent to
O32993|MLCB2492_14|ML1849|RL14_MYCLE 50S ribosomal protein
L14 from Mycobacterium leprae (122 aa). Also highly
similar to others e.g. CAB82080.1|AL161803 50S ribosomal
protein L14 from Streptomyces coelicolor (122 aa);
P33100|RL14_MICLU 50s ribosomal protein L14 from
Micrococcus luteus (122 aa), FASTA scores: opt: 674, E():
0, (85.2% identity in 122 aa overlap); etc. Contains
PS00049 Ribosomal protein L14 signature. Belongs to the
L14P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0714"
/db_xref="EnsemblGenomes-Tr:CCP43458"
/db_xref="GOA:P9WHD9"
/db_xref="InterPro:IPR000218"
/db_xref="InterPro:IPR005745"
/db_xref="InterPro:IPR019972"
/db_xref="InterPro:IPR036853"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHD9"
/inference="protein motif:PROSITE:PS00049"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43458.1"
/translation="MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVK
DAIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGPV
GRELREKRFMKIISLAPEVL"
gene 811742..812059
/gene="rplX"
/locus_tag="Rv0715"
CDS 811742..812059
/codon_start=1
/transl_table=11
/gene="rplX"
/locus_tag="Rv0715"
/product="50S ribosomal protein L24 RplX"
/note="Rv0715, (MTCY210.34), len: 105 aa. rplX, 50S
ribosomal protein L24, equivalent to O32994|MLCB2492_15
50S ribosomal protein L24 from Mycobacterium leprae (105
aa). Also highly similar to others e.g.
CAB82081.1|AL161803 50S ribosomal protein L24 from
Streptomyces coelicolor (107 aa); P12876|RL24_BACSU 50s
ribosomal protein L24 (bl23) from Bacillus subtilis (103
aa), FASTA scores: opt: 363,E(): 1.8e-18, (56.7% identity
in 104 aa overlap); etc. Contains PS01108 Ribosomal
protein L24 signature. Belongs to the L24P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0715"
/db_xref="EnsemblGenomes-Tr:CCP43459"
/db_xref="GOA:P9WHB7"
/db_xref="InterPro:IPR003256"
/db_xref="InterPro:IPR005824"
/db_xref="InterPro:IPR005825"
/db_xref="InterPro:IPR008991"
/db_xref="InterPro:IPR014722"
/db_xref="InterPro:IPR041988"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHB7"
/inference="protein motif:PROSITE:PS01108"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43459.1"
/translation="MKVHKGDTVLVISGKDKGAKGKVLQAYPDRNRVLVEGVNRIKKH
TAISTTQRGARSGGIVTQEAPIHVSNVMVVDSDGKPTRIGYRVDEETGKRVRISKRNG
KDI"
gene 812059..812622
/gene="rplE"
/locus_tag="Rv0716"
CDS 812059..812622
/codon_start=1
/transl_table=11
/gene="rplE"
/locus_tag="Rv0716"
/product="50S ribosomal protein L5 RplE"
/note="Rv0716, (MTCY210.35), len: 187 aa. rplE, 50S
ribosomal protein L5, equivalent to MLCB2492_16 50S
ribosomal protein L5 from Mycobacterium leprae (187 aa).
Also highly similar to others e.g. CAB82082.1|AL161803 50S
ribosomal protein L5 from Streptomyces coelicolor (185
aa); P33098|RL5_MICLU 50S ribosomal protein L5 from
Micrococcus luteus (191 aa), FASTA scores: opt: 930, E():
0, (73.8% identity in 183 aa overlap); etc. Belongs to the
L5P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0716"
/db_xref="EnsemblGenomes-Tr:CCP43460"
/db_xref="GOA:P9WH83"
/db_xref="InterPro:IPR002132"
/db_xref="InterPro:IPR020930"
/db_xref="InterPro:IPR022803"
/db_xref="InterPro:IPR031309"
/db_xref="InterPro:IPR031310"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43460.1"
/translation="MTTAQKVQPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVN
MGVGEAARDAKLINGAVNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDR
MWEFLDRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVRGMD
INVVTSAATDDEGRALLRALGFPFKEN"
gene 812627..812812
/gene="rpsN1"
/gene_synonym="rpsN"
/locus_tag="Rv0717"
CDS 812627..812812
/codon_start=1
/transl_table=11
/gene="rpsN1"
/gene_synonym="rpsN"
/locus_tag="Rv0717"
/product="30S ribosomal protein S14 RpsN1"
/note="Rv0717, (MTCY210.36), len: 61 aa. rpsN1, 30S
ribosomal protein S14, equivalent to MLCB2492_17|O32996
ribosomal protein S14 from Mycobacterium leprae (61 aa).
Also highly similar to others e.g. CAB82083.1|AL161803 30S
ribosomal protein S14 from Streptomyces coelicolor (61
aa); P24320|RS14_THETH 30s ribosomal protein S14 from
Thermus aquaticus (subsp. thermophilus) (60 aa), FASTA
scores: opt: 316, E(): 2e-19,(70.0% identity in 60 aa
overlap); etc. Contains PS00527 Ribosomal protein S14
signature. Belongs to the S14P family of ribosomal
proteins. Note that previously known as rpsN."
/db_xref="EnsemblGenomes-Gn:Rv0717"
/db_xref="EnsemblGenomes-Tr:CCP43461"
/db_xref="GOA:P9WH57"
/db_xref="InterPro:IPR001209"
/db_xref="InterPro:IPR018271"
/db_xref="InterPro:IPR023053"
/db_xref="UniProtKB/Swiss-Prot:P9WH57"
/inference="protein motif:PROSITE:PS00527"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43461.1"
/translation="MAKKALVNKAAGKPRFAVRAYTRCSKCGRPRAVYRKFGLCRICL
REMAHAGELPGVQKSSW"
repeat_region 812835..812921
/note="87 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
repeat_region 812922..812975
/note="54 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 812976..813374
/gene="rpsH"
/locus_tag="Rv0718"
CDS 812976..813374
/codon_start=1
/transl_table=11
/gene="rpsH"
/locus_tag="Rv0718"
/product="30S ribosomal protein S8 RpsH"
/note="Rv0718, (MTCY210.37), len: 132 aa. rpsH, 30S
ribosomal protein S8, equivalent to O32997|MLCB2492_18 30S
ribosomal protein S8 from Mycobacterium leprae (132 aa).
Also highly similar to others e.g. CAB82084.1|AL161803 30S
ribosomal protein S8 from Streptomyces coelicolor (132
aa); P33106|RS8_MICLU 30s ribosomal protein S8 from
Micrococcus luteus (132 aa), FASTA scores: opt: 669, E():
0, (77.3% identity in 132 aa overlap); etc. Contains
PS00053 Ribosomal protein S8 signature. Belongs to the S8P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0718"
/db_xref="EnsemblGenomes-Tr:CCP43462"
/db_xref="GOA:P9WH27"
/db_xref="InterPro:IPR000630"
/db_xref="InterPro:IPR035987"
/db_xref="UniProtKB/Swiss-Prot:P9WH27"
/inference="protein motif:PROSITE:PS00053"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43462.1"
/translation="MTMTDPIADFLTRLRNANSAYHDEVSLPHSKLKANIAQILKNEG
YISDFRTEDARVGKSLVIQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLG
VAIISTSSGLLTDRQAARQGVGGEVLAYVW"
gene 813398..813937
/gene="rplF"
/locus_tag="Rv0719"
CDS 813398..813937
/codon_start=1
/transl_table=11
/gene="rplF"
/locus_tag="Rv0719"
/product="50S ribosomal protein L6 RplF"
/note="Rv0719, (MTCY210.38), len: 179 aa. rplF, 50S
ribosomal protein L6, equivalent to O32998|MLCB2492_19 50S
ribosomal protein L6 from Mycobacterium leprae (179 aa).
Also highly similar to others e.g.
P46786|RL6_STRCO|CAB82085.1|AL161803|SCD31.42 50S
ribosomal protein L6 from Streptomyces coelicolor (179
aa), FASTA scores: opt: 872, E(): 0, (70.4% identity in
179 aa overlap); etc. Contains PS00525 Ribosomal protein
L6 signature 1. Belongs to the L6P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv0719"
/db_xref="EnsemblGenomes-Tr:CCP43463"
/db_xref="GOA:P9WH81"
/db_xref="InterPro:IPR000702"
/db_xref="InterPro:IPR002358"
/db_xref="InterPro:IPR019906"
/db_xref="InterPro:IPR020040"
/db_xref="InterPro:IPR036789"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH81"
/inference="protein motif:PROSITE:PS00525"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43463.1"
/translation="MSRIGKQPIPVPAGVDVTIEGQSISVKGPKGTLGLTVAEPIKVA
RNDDGAIVVTRPDDERRNRSLHGLSRTLVSNLVTGVTQGYTTKMEIFGVGYRVQLKGS
NLEFALGYSHPVVIEAPEGITFAVQAPTKFTVSGIDKQKVGQIAANIRRLRRPDPYKG
KGVRYEGEQIRRKVGKTGK"
gene 813940..814308
/gene="rplR"
/locus_tag="Rv0720"
CDS 813940..814308
/codon_start=1
/transl_table=11
/gene="rplR"
/locus_tag="Rv0720"
/product="50S ribosomal protein L18 RplR"
/note="Rv0720, (MTCY210.39), len: 122 aa. rplR, 50S
ribosomal protein L18, equivalent to
O32999|MLCB2492_20|RL18_MYCLE 50S ribosomal protein L18
from Mycobacterium leprae (122 aa). Also highly similar to
others e.g. CAB82086.1|AL161803 50S ribosomal protein L18
from Streptomyces coelicolor (127 aa); P33102|RL18_MICLU
50s ribosomal protein L18 from Micrococcus luteus (119
aa),FASTA scores: opt: 447, E(): 8.7e-24, (60.4% identity
in 111 aa overlap); etc. Belongs to the L18P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0720"
/db_xref="EnsemblGenomes-Tr:CCP43464"
/db_xref="GOA:P9WHD1"
/db_xref="InterPro:IPR004389"
/db_xref="InterPro:IPR005484"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43464.1"
/translation="MAQSVSATRRISRLRRHTRLRKKLSGTAERPRLVVHRSARHIHV
QLVNDLNGTTVAAASSIEADVRGVPGDKKARSVRVGQLIAERAKAAGIDTVVFDRGGY
TYGGRIAALADAARENGLSF"
gene 814328..814990
/gene="rpsE"
/locus_tag="Rv0721"
CDS 814328..814990
/codon_start=1
/transl_table=11
/gene="rpsE"
/locus_tag="Rv0721"
/product="30S ribosomal protein S5 RpsE"
/note="Rv0721, (MTCY210.40), len: 220 aa. rpsE, 30S
ribosomal protein S5, equivalent to MLCB2492_21 ribosomal
protein S5 from Mycobacterium leprae (217 aa). Also highly
similar to others e.g. P46790|RS5_STRCO 30s ribosomal
protein S5 from Streptomyces coelicolor (167 aa), FASTA
scores: opt: 889, E(): 0, (82.1% identity in 162 aa
overlap); etc. Note N-terminus is extented compared to
other rpsE genes. Contains PS00585 Ribosomal protein S5
signature, PTS HPr component phosphorylation sites
signature. Belongs to the S5P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv0721"
/db_xref="EnsemblGenomes-Tr:CCP43465"
/db_xref="GOA:P9WH33"
/db_xref="InterPro:IPR000851"
/db_xref="InterPro:IPR005324"
/db_xref="InterPro:IPR005712"
/db_xref="InterPro:IPR013810"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR018192"
/db_xref="InterPro:IPR020568"
/db_xref="UniProtKB/Swiss-Prot:P9WH33"
/inference="protein motif:PROSITE:PS00585"
/inference="protein motif:PROSITE:PS00589"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43465.1"
/translation="MAEQPAGQAGTTDNRDARGDREGRRRDSGRGSRERDGEKSNYLE
RVVAINRVSKVVKGGRRFSFTALVIVGDGNGMVGVGYGKAKEVPAAIAKGVEEARKSF
FRVPLIGGTITHPVQGEAAAGVVLLRPASPGTGVIAGGAARAVLECAGVHDILAKSLG
SDNAINVVHATVAALKLLQRPEEVAARRGLPIEDVAPAGMLKARRKSEALAASVLPDR
TI"
gene 814993..815190
/gene="rpmD"
/locus_tag="Rv0722"
CDS 814993..815190
/codon_start=1
/transl_table=11
/gene="rpmD"
/locus_tag="Rv0722"
/product="50S ribosomal protein L30 RpmD"
/note="Rv0722, (MTCY210.41), len: 65 aa. rpmD, 50S
ribosomal protein L30, equivalent to O33001 ribosomal
protein L30 from Mycobacterium leprae (71 aa). Also highly
similar to others e.g. P46789|RL30_STRCO 50S ribosomal
protein L30 from Streptomyces coelicolor (60 aa);
P02430|RL30_ECOLI 50S ribosomal protein L30 from
Escherichia coli (58 aa), FASTA scores: opt: 168, E():
1.5e-13, (53.7% identity in 54 aa overlap); etc. Belongs
to the L30P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv0722"
/db_xref="EnsemblGenomes-Tr:CCP43466"
/db_xref="GOA:P9WHA3"
/db_xref="InterPro:IPR005996"
/db_xref="InterPro:IPR016082"
/db_xref="InterPro:IPR018038"
/db_xref="InterPro:IPR036919"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43466.1"
/translation="MSQLKITQVRSTIGARWKQRESLRTLGLRRIRHSVIREDNAATR
GLIAVVRHLVEVEPAQTGGKT"
gene 815190..815630
/gene="rplO"
/locus_tag="Rv0723"
CDS 815190..815630
/codon_start=1
/transl_table=11
/gene="rplO"
/locus_tag="Rv0723"
/product="50S ribosomal protein L15 RplO"
/note="Rv0723, (MTCY210.42), len: 146 aa. rplO, 50S
ribosomal protein L15, equivalent to MLCB2492_23|O33002
50S ribosomal protein L15 from Mycobacterium leprae (146
aa). Also highly similar to others e.g.
P46787|RL15_STRCO|SCD31.46 50S ribosomal protein L15 from
Streptomyces coelicolor (151 aa); P19946|RL15_BACSU 50s
ribosomal protein L15 from Bacillus subtilis (146
aa),FASTA scores: opt: 419, E(): 6.5e-20, (51.0% identity
in 145 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop), and PS00475 Ribosomal protein L15
signature. Belongs to the L15P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv0723"
/db_xref="EnsemblGenomes-Tr:CCP43467"
/db_xref="GOA:P9WHD7"
/db_xref="InterPro:IPR001196"
/db_xref="InterPro:IPR005749"
/db_xref="InterPro:IPR021131"
/db_xref="InterPro:IPR030878"
/db_xref="InterPro:IPR036227"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHD7"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00475"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43467.1"
/translation="MTLKLHDLRPARGSKIARTRVGRGDGSKGKTAGRGTKGTRARKQ
VPVTFEGGQMPIHMRLPKLKGFRNRFRTEYEIVNVGDINRLFPQGGAVGVDDLVAKGA
VRKNALVKVLGDGKLTAKVDVSAHKFSGSARAKITAAGGSATEL"
gene 815663..817534
/gene="sppA"
/locus_tag="Rv0724"
CDS 815663..817534
/codon_start=1
/transl_table=11
/gene="sppA"
/locus_tag="Rv0724"
/product="Possible protease IV SppA (endopeptidase IV)
(signal peptide peptidase)"
/note="Rv0724, (MTCY210.43), len: 623 aa. Possible
sppA,protease IV (endopeptidase IV), equivalent (but
longer 23 aa) to MLCB2492_24|O33003 endopeptidase IV from
Mycobacterium leprae (602 aa). Also similar to others e.g.
NP_419743.1|NC_002696 signal peptide peptidase SppA from
Caulobacter crescentus (594 aa); P08395|SPPA_ECOLI|B1766
protease IV (endopeptidase) from Escherichia coli strain
K-12 (618 aa), FASTA scores: opt: 582, E(): 8.9e-27,
(34.1% identity in 525 aa overlap); etc. Belongs to
peptidase family S49. Conserved in M. tuberculosis, M.
leprae, M. bovis and M. avium paratuberculosis; predicted
to be essential for in vivo survival and pathogenicity
(See Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0724"
/db_xref="EnsemblGenomes-Tr:CCP43468"
/db_xref="GOA:P95072"
/db_xref="InterPro:IPR002142"
/db_xref="InterPro:IPR004634"
/db_xref="InterPro:IPR004635"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:P95072"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43468.1"
/translation="MPIFGGFCVCSRALGGRWVRWVNMVAFLPSIPVVEDLRALVGRV
DTARHHGVPNGCVLEFNLRSVPPETTGFDPLTVLTGGGRPMALRDAVAAIHRAAEDPR
VAGLIARVQLPPSPAGAVQELREAIAAFSAVKPSLAWAETYPGTLSYYLASAFGEVWM
QPSGSVGLVGFATNATFLRDALHKAGIEAQFVARGEYKSAANLFTEDGFTDAHREAVT
RMLDSLQDQVWQAVAKSRNIGVDALDELADRAPLLRDDAVTCGLIDRIGFRDQAYARM
AELVGVEKGSPESSGSQTSPDEKPPRMYLARYASSARPRLTPPVPSIPGRRSKPTIAV
VTLEGPIVNGRGGPQFLPLGPSSAGGDTIAAALREVAADDSVSAIVLRVDSPGGSVTA
SETIWREVARARDRGKPVVASMGAVAASGGYYVSMGADAIVANPGTITGSIGVITGKL
VVRDLKDRLGVGSDAVRTNANADAWSIDAPFTPDQQAHREAEADLFYSDFVERVAEGR
KMTTDAVDVVARGRVWTGADALDRGLVDELGGLRTAVRRAKVLAGLDEDTEVRIVSYP
GSSLWDMVRPRPSSRPAAASLPDAMGALLARSIVGIVEQVEQTLSGASVLWLGESRL"
gene complement(817531..>817866)
/locus_tag="Rv0724A"
CDS complement(817531..>817866)
/codon_start=1
/transl_table=11
/locus_tag="Rv0724A"
/product="Conserved hypothetical protein"
/note="Rv0724A, len: 111 aa. Similarity suggests that this
CDS should be continuation of Rv0725c but we can find no
frame-shift to account for this. Possible extended protein
is very similar to other hypothetical Mycobacterium
tuberculosis proteins e.g. Rv1729c|Z81360_12 (312
aa),FASTA scores: opt: 399, E(): 2e-19, (58.7% identity in
109 aa overlap); Rv0731c, Rv0726c, etc. Frame-shift could
occur at nt 817866. Same sequence for strain CDC1551 and
Mycobacterium bovis."
/db_xref="EnsemblGenomes-Gn:Rv0724A"
/db_xref="EnsemblGenomes-Tr:CCP43469"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:Q79FX1"
/protein_id="CCP43469.1"
/translation="SQDRLFDNSTELSVAGSTIATELVPGIVDFDAGRVREMADSFRK
HGVDIDMASLVYSGERSHVVDYLRAKGWDVEGTVRTDLFRRNGLPVPAPHDDDPLGEI
IFISGRLNG"
gene complement(817539..818444)
/locus_tag="Rv0725c"
CDS complement(817539..818444)
/codon_start=1
/transl_table=11
/locus_tag="Rv0725c"
/product="Conserved hypothetical protein"
/note="Rv0725c, (MTCY210.44c), len: 301 aa. Conserved
hypothetical protein, similar to hypothetical proteins
from Mycobacterium tuberculosis e.g. Rv0726c, Rv0731c,
Rv3399,etc, e.g. Y893_MYCTU|Q10552|Rv0893C hypothetical
36.1 kDa protein cy31.21c (325 aa), FASTA scores: opt:
600, E(): 3.9e-32, (43.8% identity in 219 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0725c"
/db_xref="EnsemblGenomes-Tr:CCP43470"
/db_xref="GOA:P95073"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:P95073"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43470.1"
/translation="MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEP
LVRAVGLDFFTKLIDGELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVR
QVVILAAGLDARAYRLPWPAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDL
RADWPAALQAAGLDSTAPTAWLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSR
ALWISTQAGYEKWRIRFASTAWTSTWRRWCIPANAATSSTTCAPRAGTLRAQCGPTYS
GAMVCPFPPHTTTIRSAKSSSSAVV"
gene complement(818537..819640)
/locus_tag="Rv0726c"
CDS complement(818537..819640)
/codon_start=1
/transl_table=11
/locus_tag="Rv0726c"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv0726c, (MTCY210.45c), len: 367 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), highly similar to other proteins from
Mycobacterium tuberculosis e.g.
Q10552|Y893_MYCTU|Rv0893c|MT0917|MTCY31.21c (325 aa),
FASTA scores: opt: 646, E(): 0, (38.3% identity in 329 aa
overlap); Rv0731c|MTV041.05c (318 aa), Rv3399, etc. Also
similar to proteins from Mycobacterium leprae and other
organisms e.g. T35930 hypothetical protein SC9B5.10 from
Streptomyces coelicolor (303 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0726c"
/db_xref="EnsemblGenomes-Tr:CCP43471"
/db_xref="GOA:P9WFI7"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFI7"
/protein_id="CCP43471.1"
/translation="MTYTGSIRCEGDTWDLASSVGATATMVAAARAMATRAANPLIND
QFAEPLVRAVGVDVLTRLASGELTASDIDDPERPNASMVRMAEHHAVRTKFFDEFFMD
ATRAGIRQVVILASGLDSRAYRLAWPAQTVVYEIDQPQVMEFKTRTLAELGATPTADR
RVVTADLRADWPTALGAAGFDPTQPTAWSAEGLLRYLPPEAQDRLLDNVTALSVPDSR
FATESIRNFKPHHEERMRERMTILANRWRAYGFDLDMNELVYFGDRNEPASYLSDNGW
LLTEIKSQDLLTANGFQPFEDEEVPLPDFFYVSARLQRKHRQYPAHRKPAPSWRHTAC
PVNELSKSAAYTMTRSDAHQASTTAPPPPGLTG"
gene complement(819843..820499)
/gene="fucA"
/locus_tag="Rv0727c"
CDS complement(819843..820499)
/codon_start=1
/transl_table=11
/gene="fucA"
/locus_tag="Rv0727c"
/product="Possible L-fuculose phosphate aldolase FucA
(L-fuculose-1-phosphate aldolase)"
/note="Rv0727c, (MTV41.01c, MTCY210.46c), len: 218 aa.
Possible fucA, L-fuculose-1-phosphate aldolase, similar to
many e.g. NP_386339.1|NC_003047 putative L-fuculose
phosphate aldolase protein from Sinorhizobium meliloti
(222 aa); P11550|FUCA_ECOLI L-fuculose phosphate aldolase
from Escherichia strain K12 (215 aa), FASTA scores: opt:
372,E(): 4.1e-19, (34.6% identity in 185 aa overlap); etc.
Belongs to the aldolase class II family, ARAD/FUCA
subfamily. Cofactor: binds one zinc ion per molecule."
/db_xref="EnsemblGenomes-Gn:Rv0727c"
/db_xref="EnsemblGenomes-Tr:CCP43472"
/db_xref="GOA:P95075"
/db_xref="InterPro:IPR001303"
/db_xref="InterPro:IPR036409"
/db_xref="UniProtKB/TrEMBL:P95075"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43472.1"
/translation="MNFVDAPESAVLAAAKDMLRRGLVEGTAGNISARRSDGNVVITP
SSVDYAEMLLHDLVLVDAGGAVLHAKDGRSPSTELNLHLACYRAFDDIGSVIHSHPVW
ATMFAVAHEPIPACIDEFAIYCGGDVRCTEYAASGTPEVGRNAVRALEGRAAALIANH
GLVAVGPRPDQVLRVTALVERTAQIVWGARALGGPVPIPEDVCRNFTGVYGYLRANPL
"
gene complement(820496..821476)
/gene="serA2"
/locus_tag="Rv0728c"
CDS complement(820496..821476)
/codon_start=1
/transl_table=11
/gene="serA2"
/locus_tag="Rv0728c"
/product="Possible D-3-phosphoglycerate dehydrogenase
SerA2 (phosphoglycerate dehydrogenase) (PGDH)"
/note="Rv0728c, (MTV041.02c), len: 326 aa. Possible
serA2,D-3-phosphoglycerate dehydrogenase, similar to
others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate
dehydrogenase from Bacillus subtilis (344 aa), FASTA
scores: opt: 594,E(): 3.1e-31, (35.9% identity in 309 aa
overlap); etc. Also similar to Rv2996c|MTV012.10|SERA1
D-3-phosphoglycerate dehydrogenase from Mycobacterium
tuberculosis (528 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0728c"
/db_xref="EnsemblGenomes-Tr:CCP43473"
/db_xref="GOA:I6WZ71"
/db_xref="InterPro:IPR006139"
/db_xref="InterPro:IPR006140"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6WZ71"
/protein_id="CCP43473.1"
/translation="MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAE
QLADRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVLHT
PARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGL
VGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGM
IGAQQFAAMRDGAVFLNTARSQLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLV
SMPNVVLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS"
gene 821507..822853
/gene="xylB"
/locus_tag="Rv0729"
CDS 821507..822853
/codon_start=1
/transl_table=11
/gene="xylB"
/locus_tag="Rv0729"
/product="Possible D-xylulose kinase XylB (xylulokinase)
(xylulose kinase)"
/note="Rv0729, (MTV041.03), len: 448 aa. Possible
xylB,D-xylulose-kinase (xylulokinase). C-terminus highly
similar to AAD09880.1|U77912 unknown protein from
Mycobacterium bovis (102 aa); and N-terminus highly
similar to T45387|Z98756|MLCB2492_25 hypothetical protein
from Mycobacterium leprae (110 aa), FASTA scores: opt:
427, E(): 1.1e-19, (60.9% identity in 110 aa overlap).
Also similar to xylA/xylB genes from various bacterial
species e.g. AAC26499.1|AF045245 D-xylulose-kinase from
Klebsiella pneumoniae (487 aa); NP_418021.1|NC_000913
xylulokinase from Escherichia coli strain K12 (484 aa),
FASTA scores: opt: 260, E(): 7.5e-09, (25.9% identity in
478 aa overlap); etc. Also similar to Rv3696c|glpK
probable glycerol kinase from Mycobacterium tuberculosis
(517 aa). Belongs to the fucokinase / gluconokinase /
glycerokinase / xylulokinase family."
/db_xref="EnsemblGenomes-Gn:Rv0729"
/db_xref="EnsemblGenomes-Tr:CCP43474"
/db_xref="GOA:I6Y4K0"
/db_xref="InterPro:IPR000577"
/db_xref="InterPro:IPR018484"
/db_xref="InterPro:IPR018485"
/db_xref="UniProtKB/TrEMBL:I6Y4K0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43474.1"
/translation="MSRDDVTIGIDIGTTAVKAVAADDNGRVTARVRIGHQLAVPAPD
RLEHDADEAWRRGPLAALDRLVGPDTRALAVAAMVPSLTAVDPAGRPITPGLLYGDAR
GRVPNASVARAQSVPSVGETAEFLRWTAGQALDASGYWPAPAVANYALSGEAVIDYAT
AVTTLPLFDGTGWNATACADCGVTVDRMPRVETFGVGVGQVRGTGAVLAVGAVDALCE
QIVAGADRDGDVLVLCGATLIVWTTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLF
LNWVDRVIGPGDPALADPRRVPVWLPYIRGERTPFHEPDRRAVLDGVDLSQDAASVRR
AAYEASGFVVRQLIELSGAPVARIVAAGGGTRIQPWMQAIADATGRPVEVSRVAEGAA
LGAAFLGRLAAGLESSIADAARWASTDRIVEPSADWAGPTKERYRRFLALSGSKLA"
gene 822866..823594
/locus_tag="Rv0730"
CDS 822866..823594
/codon_start=1
/transl_table=11
/locus_tag="Rv0730"
/product="GCN5-related N-acetyltransferase"
/note="Rv0730, (MTV041.04), len: 242 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain in C-terminal part. See
Vetting et al. 2005. Equivalent to Z98756|MLCB2492_26
hypothetical protein from Mycobacterium leprae (227 aa),
FASTA scores: opt: 1180, E(): 0, (83.5% identity in 218 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0730"
/db_xref="EnsemblGenomes-Tr:CCP43475"
/db_xref="GOA:I6XW38"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR013757"
/db_xref="InterPro:IPR013760"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:I6XW38"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43475.1"
/translation="MHGARTGVSFYAYAMTDHDQTAARREIADALLAALERRHEVADA
IVEAANKAAAVEAIVNLLGTSHLAAEAVMSMSFDQLTQDARTKIIAELDDLNKQLSFT
VKERPASSGEGLELRPFSPDEDRDIFARRTEEMGAAGDGSGGPAGSVDDEIRAAQKRV
DDEEAAWFVAVDSGVKVGMVFGELVHGEVDVRIWIHPDHRKKGYGTAALRKSRSEMAW
AFPAVPMVARAPAAQPAQPGSAGR"
gene complement(823683..824639)
/locus_tag="Rv0731c"
CDS complement(823683..824639)
/codon_start=1
/transl_table=11
/locus_tag="Rv0731c"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv0731c, (MTV041.05c), len: 318 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), highly similar to other proteins from
Mycobacterium tuberculosis e.g. Rv0726c|MTCY210.45c (367
aa), FASTA score: (60.9% identity in 317 aa overlap);
Rv3399, Rv1729c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0731c"
/db_xref="EnsemblGenomes-Tr:CCP43476"
/db_xref="GOA:P9WFI5"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43476.1"
/translation="MTQTGSARFEGDSWDLASSVGLTATMVAAARAVAGRAPGALVND
QFAEPLVRAVGVDFFVRMASGELDPDELAEDEANGLRRFADAMAIRTHYFDNFFLDAT
RAGIRQAVILASGLDSRAYRLRWPAGTIVFEVDQPQVIDFKTTTLAGLGAAPTTDRRT
VAVDLRDDWPTALQKAGFDNAQRTAWIAEGLLGYLSAEAQDRLLDQITAQSVPGSQFA
TEVLRDINRLNEEELRGRMRRLAERFRRHGLDLDMSGLVYFGDRTDARTYLADHGWRT
ASASTTDLLAEHGLPPIDGDDAPFGEVIYVSAELKQKHQDTR"
gene 824800..826125
/gene="secY"
/locus_tag="Rv0732"
CDS 824800..826125
/codon_start=1
/transl_table=11
/gene="secY"
/locus_tag="Rv0732"
/product="Probable preprotein translocase SecY"
/note="Rv0732, (MTV041.06), len: 441 aa. Probable
SecY,preprotein translocase (integral membrane protein)
(see citation below), equivalent to NP_302243.1|NC_002677
SecY subunit of preprotein translocase from Mycobacterium
leprae (438 aa); AAC04389.1|AF047021 preprotein
translocase subunit from Mycobacterium smegmatis (438 aa);
and U77912|MBU77912_1 preprotein translocase subunit from
Mycobacterium bovis (441 aa), FASTA scores: opt: 2802,
E(): 0, (99.8% identity in 441 aa overlap). Also highly
similar to others e.g. P46785|SECY_STRCO preprotein
translocase SECY subunit from Streptomyces coelicolor (437
aa); etc. Contains PS00755 and PS00756 protein secY
signatures 1 and 2. Belongs to the SECE/SEC61-alpha
family. Part of the prokaryotic protein translocation
apparatus which comprise SECA|Rv3240c, SECD|Rv2587c,
SECE|Rv0638, SECF|Rv2586c,SECG|Rv1440 and SECY."
/db_xref="EnsemblGenomes-Gn:Rv0732"
/db_xref="EnsemblGenomes-Tr:CCP43477"
/db_xref="GOA:P9WGN3"
/db_xref="InterPro:IPR002208"
/db_xref="InterPro:IPR023201"
/db_xref="InterPro:IPR026593"
/db_xref="InterPro:IPR030659"
/db_xref="UniProtKB/Swiss-Prot:P9WGN3"
/inference="protein motif:PROSITE:PS00755"
/inference="protein motif:PROSITE:PS00756"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43477.1"
/translation="MLSAFISSLRTVDLRRKILFTLGIVILYRVGAALPSPGVNFPNV
QQCIKEASAGEAGQIYSLINLFSGGALLKLTVFAVGVMPYITASIIVQLLTVVIPRFE
ELRKEGQAGQSKMTQYTRYLAIALAILQATSIVALAANGGLLQGCSLDIIADQSIFTL
VVIVLVMTGGAALVMWMGELITERGIGNGMSLLIFVGIAARIPAEGQSILESRGGVVF
TAVCAAALIIIVGVVFVEQGQRRIPVQYAKRMVGRRMYGGTSTYLPLKVNQAGVIPVI
FASSLIYIPHLITQLIRSGSGVVGNSWWDKFVGTYLSDPSNLVYIGIYFGLIIFFTYF
YVSITFNPDERADEMKKFGGFIPGIRPGRPTADYLRYVLSRITLPGSIYLGVIAVLPN
LFLQIGAGGTVQNLPFGGTAVLIMIGVGLDTVKQIESQLMQRNYEGFLK"
gene 826122..826667
/gene="adk"
/locus_tag="Rv0733"
CDS 826122..826667
/codon_start=1
/transl_table=11
/gene="adk"
/locus_tag="Rv0733"
/product="Adenylate kinase Adk (ATP-AMP
transphosphorylase)"
/note="Rv0733, (MTV041.07), len: 181 aa. adk, adenylate
kinase (ATP-AMP transphosphorylase), equivalent to
Z98756|MLCB24 92_28 probable adenylate kinase from
Mycobacterium leprae (181 aa), FASTA scores: opt: 978,
E(): 0, (83.6% identity in 177 aa overlap); and
AAF86323.1|AF271342 putative adenylate kinase from
Mycobacterium marinum (124 aa) (N-terminus shorter). Also
highly similar to others e.g. P43414|KAD_STRCO adenylate
kinase from Streptomyces coelicolor (217 aa), FASTA score:
(43.0% identity in 186 aa overlap); etc. Contains PS00113
Adenylate kinase signature. Belongs to the adenylate
kinase family."
/db_xref="EnsemblGenomes-Gn:Rv0733"
/db_xref="EnsemblGenomes-Tr:CCP43478"
/db_xref="GOA:P9WKF5"
/db_xref="InterPro:IPR000850"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR033690"
/db_xref="PDB:1P4S"
/db_xref="PDB:2CDN"
/db_xref="UniProtKB/Swiss-Prot:P9WKF5"
/inference="protein motif:PROSITE:PS00113"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43478.1"
/translation="MRVLLLGPPGAGKGTQAVKLAEKLGIPQISTGELFRRNIEEGTK
LGVEAKRYLDAGDLVPSDLTNELVDDRLNNPDAANGFILDGYPRSVEQAKALHEMLER
RGTDIDAVLEFRVSEEVLLERLKGRGRADDTDDVILNRMKVYRDETAPLLEYYRDQLK
TVDAVGTMDEVFARALRALGK"
gene 826670..827470
/gene="mapA"
/gene_synonym="map"
/locus_tag="Rv0734"
CDS 826670..827470
/codon_start=1
/transl_table=11
/gene="mapA"
/gene_synonym="map"
/locus_tag="Rv0734"
/product="Methionine aminopeptidase MapA (map) (peptidase
M) (MetAP)"
/note="Rv0734, (MTV041.08), len: 266 aa. mapA, methionine
aminopeptidase (map), equivalent to Z98756|MLCB2492_29
probable methionine aminopeptidase from Mycobacterium
leprae (266 aa), FASTA scores: opt: 1717, E(): 0, (83.4%
identity in 265 aa overlap). Also highly similar to many
e.g. T35553 methionine aminopeptidase from Streptomyces
coelicolor (278 aa); etc. Also similar to Rv2861c|MAPB
probable methionine aminopeptidase from Mycobacterium
tuberculosis (285 aa). Belongs to peptidase family M24A;
also known as the map family 1. Cofactor: cobalt; binds 2
ions per subunit. Conserved in M. tuberculosis, M.
leprae,M. bovis and M. avium paratuberculosis; predicted
to be essential for in vivo survival and pathogenicity
(See Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0734"
/db_xref="EnsemblGenomes-Tr:CCP43479"
/db_xref="GOA:P9WK21"
/db_xref="InterPro:IPR000994"
/db_xref="InterPro:IPR001714"
/db_xref="InterPro:IPR002467"
/db_xref="InterPro:IPR036005"
/db_xref="UniProtKB/Swiss-Prot:P9WK21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43479.1"
/translation="MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAP
GTSSLSLDEIAESVIRESGATPSFLGYHGYPASICASINDRVVHGIPSTAEVLAPGDL
VSIDCGAVLDGWHGDAAITFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAH
AIETGTRAAELRYGRSFGIVAGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAI
EPMLTLGTTKTVVLDDKWTVTTADGSRAAHWEHTVAVTDDGPRILTLG"
gene 827543..828076
/gene="sigL"
/locus_tag="Rv0735"
CDS 827543..828076
/codon_start=1
/transl_table=11
/gene="sigL"
/locus_tag="Rv0735"
/product="Probable alternative RNA polymerase sigma factor
SigL"
/note="Rv0735, (MTV041.09), len: 177 aa. Probable
sigL,alternative RNA polymerase sigma factor (rpoE) (see
citations below), highly similar to many proteins of the
extracytoplasmatic function (ECF) subfamily e.g.
CAB72200.1|AL138851 putative RNA polymerase sigma factor
from Streptomyces coelicolor (194 aa); Q06909|CARQ_MYXXA
RNA polymerase sigma factor CARQ from Myxococcus xanthus
(174 aa), FASTA scores: opt: 251, E(): 9.6e-11, (32.9%
identity in 161 aa overlap); etc. Also similar to
MTCI61_4,MTU87242_1, and MLU15180_30 from Mycobacterium
tuberculosis. Contains PS01063 Sigma-70 factors ECF
subfamily signature and probable helix-turn helix motif
from aa 139-160 (Score 1134, +3.05 SD). Belongs to the
sigma-70 factor family, ECF subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0735"
/db_xref="EnsemblGenomes-Tr:CCP43480"
/db_xref="GOA:P9WGH5"
/db_xref="InterPro:IPR000838"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR007630"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039425"
/db_xref="PDB:3HUG"
/db_xref="PDB:6DV9"
/db_xref="PDB:6DVB"
/db_xref="PDB:6DVC"
/db_xref="PDB:6DVD"
/db_xref="PDB:6DVE"
/db_xref="UniProtKB/Swiss-Prot:P9WGH5"
/inference="protein motif:PROSITE:PS01063"
/protein_id="CCP43480.1"
/translation="MARVSGAAAAEAALMRALYDEHAAVLWRYALRLTGDAAQAEDVV
QETLLRAWQHPEVIGDTARPARAWLFTVARNMIIDERRSARFRNVVGSTDQSGTPEQS
TPDEVNAALDRLLIADALAQLSAEHRAVIQRSYYRGWSTAQIATDLGIAEGTVKSRLH
YAVRALRLTLQELGVTR"
gene 828140..828892
/gene="rslA"
/locus_tag="Rv0736"
CDS 828140..828892
/codon_start=1
/transl_table=11
/gene="rslA"
/locus_tag="Rv0736"
/product="Anti-sigma factor RslA"
/note="Rv0736, (MTV041.10), len: 250 aa. RslA, anti-sigma
factor (See Dainese et al., 2006). Probable membrane
protein, showing weak similarity with AL133469|SCM10_32
putative membrane protein from Streptomyces coelicolor
(216 aa), FASTA scores: opt: 180, E(): 0.00018, (34.3%
identity in 216 aa overlap). Cleaved by Rip|Rv2869c, in M.
tuberculosis Erdman (See Sklar et al., 2010)."
/db_xref="EnsemblGenomes-Gn:Rv0736"
/db_xref="EnsemblGenomes-Tr:CCP43481"
/db_xref="GOA:P9WJ67"
/db_xref="InterPro:IPR027383"
/db_xref="PDB:3HUG"
/db_xref="UniProtKB/Swiss-Prot:P9WJ67"
/protein_id="CCP43481.1"
/translation="MTMPLRGLGPPDDTGVREVSTGDDHHYAMWDAAYVLGALSAADR
REFEAHLAGCPECRGAVTELCGVPALLSQLDRDEVAAISESAPTVVASGLSPELLPSL
LAAVHRRRRRTRLITWVASSAAAAVLAIGVLVGVQGHSAAPQRAAVSALPMAQVGTQL
LASTVSISGEPWGTFINLRCVCLAPPYASHDTLAMVVVGRDGSQTRLATWLAEPGHTA
TPAGSISTPVDQIAAVQVVAADTGQVLLQRSL"
gene 829207..829704
/locus_tag="Rv0737"
CDS 829207..829704
/codon_start=1
/transl_table=11
/locus_tag="Rv0737"
/product="Possible transcriptional regulatory protein"
/note="Rv0737, (MTV041.11), len: 165 aa. Possible
transcriptional regulator, similar to others e.g.
BAB69161.1|AB070937 regulator protein from Streptomyces
avermitilis (169 aa); NP_419731.1|NC_002696
transcriptional regulator MarR family from Caulobacter
crescentus (148 aa) (homology only at C-terminus); etc.
Also shows weak similarity to AB0014|AB001488_14
hypothetical protein from Bacillus subtilis (164 aa),
FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in
116 aa overlap), which is similar to slyY gene of S.
typhimurium required for survival in macrophage. Contains
possible helix-turn helix motif from aa 73-94 (Score 1138,
+3.06 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0737"
/db_xref="EnsemblGenomes-Tr:CCP43482"
/db_xref="GOA:I6Y8K3"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:I6Y8K3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43482.1"
/translation="MASDNRDPIAAARANWERSGWGDVSLGMVAVTSVMRAHQILLAR
VETALRPYDLSFSRFELLRLLAFSRIGALPITKASDRLQVHVTSVTHAIRRLEADGLV
RRVPHPTDGRTTLVQITELGRSTVEDATVTLNEQVFANVGMGAEESQALVSAVETLRR
NAGDF"
gene 830062..830610
/locus_tag="Rv0738"
CDS 830062..830610
/codon_start=1
/transl_table=11
/locus_tag="Rv0738"
/product="Conserved protein"
/note="Rv0738, (MTV041.12), len: 182 aa. Conserved
protein,showing weak similarity with hypothetical proteins
from Mycobacterium tuberculosis: Rv1727|MTCY04C12.12 (189
aa); MTY13D12_7|Z80343 hypothetical protein from
Mycobacterium tuberculosis (194 aa), FASTA scores: opt:
172, E(): 0.0004,(24.2% identity in 178 aa overlap); and
C-terminus of Rv0576."
/db_xref="EnsemblGenomes-Gn:Rv0738"
/db_xref="EnsemblGenomes-Tr:CCP43483"
/db_xref="GOA:P9WKS3"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR017520"
/db_xref="InterPro:IPR024344"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/Swiss-Prot:P9WKS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43483.1"
/translation="MDPLMAHQRAQDAFAALLANVRADQLGGPTPCSEWTINDLIEHV
VGGNEQVGRWAASPIEPPARPDGLVAAHQAAAAVAHEIFAAPGGMSATFKLPLGEVPG
QVFIGLRTTDVLTHAWDLAAATGQSTDLDPELAVERLAAARALVGPQFRGPGKPFADE
KPCPRERPPADQLAAFLGRTVR"
gene 830855..831661
/locus_tag="Rv0739"
CDS 830855..831661
/codon_start=1
/transl_table=11
/locus_tag="Rv0739"
/product="Conserved hypothetical protein"
/note="Rv0739, (MTV041.13), len: 268 aa. Conserved
hypothetical protein, showing some similarity to
Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA
score: (37.6% identity in 101 aa overlap)and Rv0025 (120
aa), FASTA score: (32.4% identity in 142 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0739"
/db_xref="EnsemblGenomes-Tr:CCP43484"
/db_xref="GOA:P9WKS1"
/db_xref="InterPro:IPR019710"
/db_xref="UniProtKB/Swiss-Prot:P9WKS1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43484.1"
/translation="MVLTRRAREVALTQHIGVSAETDRAVVPKLRQAYDSLVCGRRRL
GAIGAEIENAVAHQRALGLDTPAGARNFSRFLATKAHDITRVLAATAAESQAGAARLR
SLASSYQAVGFGPKPQEPPPDPVPFPPYQPKVWAACRARGQDPDKVVRTFHHAPMSAR
FRSLPAGDSVLYCGNDKYGLLHIQAKHGRQWHDIADARWPSAGNWRYLADYAIGATLA
YPERVEYNQDNDTFAVYRRMSLPDGRYVFTTRVIISARDGKIITAFPQTT"
gene 831776..832303
/locus_tag="Rv0740"
CDS 831776..832303
/codon_start=1
/transl_table=11
/locus_tag="Rv0740"
/product="Conserved hypothetical protein"
/note="Rv0740, (MTV041.14), len: 175 aa. Conserved
hypothetical protein; C-terminus (possibly part of
truncated IS1557) shows nearly perfect identity to
Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% identity in
81 aa overlap). Also shows weak similarity to MTV007_5
hypothetical protein from Mycobacterium tuberculosis (313
aa), FASTA score: (34.5% identity in 110 aa overlap); and
MLCL536_27 hypothetical protein from Mycobacterium leprae
(315 aa), FASTA score: (34.5% identity in 84 aa overlap).
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0740"
/db_xref="EnsemblGenomes-Tr:CCP43485"
/db_xref="UniProtKB/Swiss-Prot:O53803"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43485.1"
/translation="MLPKNTRPTSETAEEFWDNSLWCSWGDRETGYTRTVTVSICQVA
DGEREAEGVRDMMRLECPAGLDLRTPNPEAYEITGQRPGEFVFVLGYLGHVRAIVGNC
YIEIMPMGTRVELSKLADVALDIGRSVGCSAYENDFTLPDIPTQWRNQPLGWYTQGLA
PYLPGLSDPKDAAEG"
mobile_element 832352..832868
/mobile_element_type="insertion sequence:IS1557'-1"
/note="IS1557'-1, len: 517 nt. Region similar to Insertion
sequence IS1557 on MTCY373- (IS1557- 1st copy). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
gene 832534..832848
/locus_tag="Rv0741"
CDS 832534..832848
/codon_start=1
/transl_table=11
/locus_tag="Rv0741"
/product="Probable transposase (fragment)"
/note="Rv0741, (MTV041.15), len: 104 aa. Probable
truncated transposase for IS1557, showing similarity to
transposases and is elements e.g. U63997|EFU63997_1
insertion sequence from Enterococcus faecium (424 aa),
FASTA score: (31.0% identity in 87 aa overlap). Very high
similarity with the C-terminal part of Z73419|MTCY373_3 2
IS1557 from Mycobacterium tuberculosis (444 aa), FASTA
score: (86.5% identity in 104 aa overlap). This region is
a possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0741"
/db_xref="EnsemblGenomes-Tr:CCP43486"
/db_xref="InterPro:IPR002560"
/db_xref="UniProtKB/TrEMBL:I6X9N4"
/protein_id="CCP43486.1"
/translation="MFSVKGEEGKQALDRWISWARRCRIPVFVELAGGIVRHRQAIDA
ALDHGLWQGLIESTNTKIRLLTRIAFGFRSPEALIALAMLALGGRRPALPGRTKHPRI
SQ"
gene 832981..833508
/gene="PE_PGRS8"
/locus_tag="Rv0742"
CDS 832981..833508
/codon_start=1
/transl_table=11
/gene="PE_PGRS8"
/locus_tag="Rv0742"
/product="PE-PGRS family protein PE_PGRS8"
/note="Rv0742, (MTV041.16), len: 175 aa. PE_PGRS8, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
similar to many Mycobacterium tuberculosis PGRS-type
proteins e.g. Z78020|MTCY1A11_25 (498 aa), FASTA scores:
opt: 766, E(): 6.1e-25, (73.6% identity in 178 aa
overlap). Similarity suggests ORF starts with ATA start
codon. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0742"
/db_xref="EnsemblGenomes-Tr:CCP43487"
/db_xref="GOA:I6Y8K5"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:I6Y8K5"
/protein_id="CCP43487.1"
/translation="MSFVIAAPEAIAAAATDLASIGSTIGAANAAAAANTTAVLAAGA
DQVSVAIAAAFGAHGQAYQALSAQAATFHIQFVQALTAGAGSYAAAEAASAASITSPL
LDAINAPFLAALGRPLIGNGADGAPGTGAAGGAGGLLFGNGGAGGSGAPGGAGGLLFG
NGGAGGPGASGGALG"
gene complement(833886..834443)
/locus_tag="Rv0743c"
CDS complement(833886..834443)
/codon_start=1
/transl_table=11
/locus_tag="Rv0743c"
/product="Hypothetical protein"
/note="Rv0743c, (MTV041.17c), len: 185 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0743c"
/db_xref="EnsemblGenomes-Tr:CCP43488"
/db_xref="UniProtKB/TrEMBL:I6WZ83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43488.1"
/translation="MTRQQLAHLLRRACAVVGDVDVLVLGSQSILGSFDENELPPQAT
ASQEADIAFVNDPARDKADHVDVAIGEMSDFHRSNGVYAEGVHIDTAILPNGWRDRLV
SWTVESSRPAKPRFLEPHDLAVAKLAAGREKDKAFVAALIRSGLLDVGVIQARVLLLP
EETDPRIGQRIAAWLNYYGAGNHSS"
gene complement(834440..834946)
/locus_tag="Rv0744c"
CDS complement(834440..834946)
/codon_start=1
/transl_table=11
/locus_tag="Rv0744c"
/product="Possible transcriptional regulatory protein"
/note="Rv0744c, (MTV041.18c), len: 168 aa. Possible
transcriptional regulator, showing weak similarity with
O86661|SC4A2.05 putative two-component sensor from
Streptomyces coelicolor (436 aa), FASTA scores: opt:
117,E(): 0.88, (37.25% identity in 94 aa overlap); and
some putative excisionases or transposases. Also weakly
similar to P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c
conserved hypothetical protein from Mycobacterium
tuberculosis (114 aa); and
Q11144|Y477_MYCTU|Rv0477|MT0495|MTCY20G9.03 conserved
hypothetical protein from Mycobacterium tuberculosis (148
aa). Equivalent to AAK45006 from Mycobacterium
tuberculosis strain CDC1551 (179 aa) but shorter 11 aa.
Contains probable helix-turn helix motif from aa 5-26
(Score 1350, +3.78 SD). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0744c"
/db_xref="EnsemblGenomes-Tr:CCP43489"
/db_xref="GOA:O53807"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR010093"
/db_xref="InterPro:IPR041657"
/db_xref="UniProtKB/TrEMBL:O53807"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43489.1"
/translation="METLLKTSEAAQILGVSRQHVVNMCDRGEMVCVHVGSHRRVPSS
EVERVTSRRLTREEERSLWLHRALLSPLLTEPDTVVSAARENLRRWSGMHRRDGMAGW
YFTKWQRVLNDGLDAVMHVLTSPSEDAREMRQNSPFAGILPEATRVAVLRSFKDHWDR
EHERAMTE"
gene 835154..835681
/locus_tag="Rv0745"
CDS 835154..835681
/codon_start=1
/transl_table=11
/locus_tag="Rv0745"
/product="Conserved hypothetical protein"
/note="Rv0745, (MTV041.19), len: 175 aa. Conserved
hypothetical protein; shows high similarity to a 50 aa
region of Rv3649|Z95436|MTY15C10_3 conserved hypothetical
protein, similar to ATP-dependent helicases, from
Mycobacterium tuberculosis (771 aa), FASTA scores: opt:
225, E(): 7e-06, (70.0% identity in 50 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0745"
/db_xref="EnsemblGenomes-Tr:CCP43490"
/db_xref="UniProtKB/TrEMBL:I6X9N8"
/protein_id="CCP43490.1"
/translation="MGPPHRSRPPLPSPGPTCQVLPTTAVIHTVTAEALGRIGIDAPR
IPGSLDVAAHAAIGLLPLVAGCDRRHRRPVRGARAGRAAQVSLCMTAIRVEPVSSNAV
CTGPAAQVGDQSRSPQRDYAHQALQPDVPRRRARRHRPRRCSAKTGSSSSTMRCTCHQ
NQCLWSSGVSWALAR"
gene 835701..838052
/gene="PE_PGRS9"
/locus_tag="Rv0746"
CDS 835701..838052
/codon_start=1
/transl_table=11
/gene="PE_PGRS9"
/locus_tag="Rv0746"
/product="PE-PGRS family protein PE_PGRS9"
/note="Rv0746, (MTV041.20), len: 783 aa. PE_PGRS9, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
highly similar to part of MTCY28.25c|Rv1759c|Z95890
antigen wag22 from M. tuberculosis (914 aa), FASTA scores:
opt: 2429, E(): 0,(56.9% identity in 873 aa overlap). Also
similar to other PE-PGRS family proteins e.g.
AL0212|MTV008_46 FASTA score: (48.8% identity in 887 aa
overlap); etc. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0746"
/db_xref="EnsemblGenomes-Tr:CCP43491"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FW8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43491.1"
/translation="MSFVLAMPEVLGSAATDLAALGSVLGAADAAAAATTTGIVAAAQ
DEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSAGAGAYASAEAAGAAVLANPA
QSVQQDLLAAVNAQSVALTGRPLIGNGANGAPGTGANGAPGGWLLGNGGAGGSAAAGS
GLPGGAGGAAGLFGTGGAGGAGGSSTVGDGEAGGAGGSGGWLLGTGGVGGVGGLGAGA
GGAGGVGGAGGLLGAGGHGGAGGLGAVTGGVGGTGGAGGLLAGLLAGPGGAGGTGGRG
FLNNGGVGGAGGNAGLLFGAGGTGGSGGAGLGGDGGAGGAGGNTGVLFGNAGSGGTGG
FGDTDGGAGGAGGDAGWLGSGGVGGAGGFGETGDGGVGGAGGKAGLLIGNGGAGGAGG
QGAVTGGTGGAGGDGVLIGNGGNAGIGGTGPTAGDTGAGGISGLLLGADGFNTPASAS
PLHTLKQQALAAINAPTQTLTGRPLIGNGTPGAVGSGATGAPGGWLLGDGGAGGSGAA
GSGAPGGAGGAAGLWGTGGAGGAGGSSAGGGGAGGAGGAGGWLLGDGGAGGIGGASTV
LGGTGGGGGVGGLWGAGGAGGAGGTGLVGGDGGAGGAGGTGGLLAGLIGAGGGHGGTG
GLSTNGDGGVGGAGGNAGMLAGPGGAGGAGGDGENLDTGGDGGAGGSAGLLFGSGGAG
GAGGFGFLGGDGGAGGNAGLLLSSGGAGGFGGFGTAGGVGGAGGNAGWLGFGGAGGVG
GSAGLIGTGGNGGNGGTGANAGSPGTGGAGGLLLGQNGLNGLP"
gene 838451..840856
/gene="PE_PGRS10"
/locus_tag="Rv0747"
CDS 838451..840856
/codon_start=1
/transl_table=11
/gene="PE_PGRS10"
/locus_tag="Rv0747"
/product="PE-PGRS family protein PE_PGRS10"
/note="Rv0747, (MTV041.21), len: 801 aa. PE_PGRS10, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
highly similar to part of MTCY28.25c|Rv1759c|Z95890
antigen wag22 from M. tuberculosis (914 aa), FASTA scores:
opt: 2772, E(): 0,(60.9% identity in 941 aa overlap). Also
similar to other PE-PGRS family proteins e.g.
Z95844|MTCY493_2 FASTA score: (50.2% identity in 815 aa
overlap). Contains PS00012 Phosphopantetheine attachment
site. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0747"
/db_xref="EnsemblGenomes-Tr:CCP43492"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIG1"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43492.1"
/translation="MSWVMVSPELVVAAAADLAGIGSAISSANAAAAVNTTGLLTAGA
DEVSTAIAALFGAQGQAYQAASAQAAAFYAQFVQALSAGGGAYAAAEAAAVSPLLAPI
NAQFVAATGRPLIGNGANGAPGTGANGGPGGWLIGNGGAGGSGAPGAGAGGNGGAGGL
FGSGGAGGASTDVAGGAGGAGGAGGNAGMLFGAAGVGGVGGFSNGGATGGAGGAGGAG
GLFGAGRERGSGGSGNLTGGAGGAGGNAGTLATGDGGAGGTGGASRSGGFGGAGGAGG
DAGMFFGSGGSGGAGGISKSVGDSAAGGAGGAPGLIGNGGNGGNGGASTGGGDGGPGG
AGGTGVLIGNGGNGGSGGTGATLGKAGIGGTGGVLLGLDGFTAPASTSPLHTLQQDVI
NMVNDPFQTLTGRPLIGNGANGTPGTGADGGAGGWLFGNGGNGGQGTIGGVNGGAGGA
GGAGGILFGTGGTGGSGGPGATGLGGIGGAGGAALLFGSGGAGGSGGAGAVGGNGGAG
GNAGALLGAAGAGGAGGAGAVGGNGGAGGNGGLFANGGAGGPGGFGSPAGAGGIGGAG
GNGGLFGAGGTGGAGGGSTLAGGAGGAGGNGGLFGAGGTGGAGSHSTAAGVSGGAGGA
GGDAGLLSLGASGGAGGSGGSSLTAAGVVGGIGGAGGLLFGSGGAGGSGGFSNSGNGG
AGGAGGDAGLLVGSGGAGGAGASATGAATGGDGGAGGKSGAFGLGGDGGAGGATGLSG
AFHIGGKGGVGGSAVLIGNGGNGGNGGNSGNAGKSGGAPGPSGAGGAGGLLLGENGLN
GLM"
gene 840947..841204
/gene="vapB31"
/locus_tag="Rv0748"
CDS 840947..841204
/codon_start=1
/transl_table=11
/gene="vapB31"
/locus_tag="Rv0748"
/product="Possible antitoxin VapB31"
/note="Rv0748, (MTV041.22), len: 85 aa. Possible
vapB31,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0749,see Arcus et al. 2005. Also similar to others in
Mycobacterium tuberculosis proteins e.g. Rv2871 (75 aa);
Rv1241, Rv2132, Rv3321c, etc. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0748"
/db_xref="EnsemblGenomes-Tr:CCP43493"
/db_xref="GOA:O53811"
/db_xref="InterPro:IPR002145"
/db_xref="UniProtKB/Swiss-Prot:O53811"
/protein_id="CCP43493.1"
/translation="MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVG
GARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLELNSRK"
gene 841228..841656
/gene="vapC31"
/locus_tag="Rv0749"
CDS 841228..841656
/codon_start=1
/transl_table=11
/gene="vapC31"
/locus_tag="Rv0749"
/product="Possible toxin VapC31. Contains PIN domain."
/note="Rv0749, (MTV041.23), len: 142 aa. Possible
vapC31,toxin, part of toxin-antitoxin (TA) operon with
Rv0748,contains PIN domain, see Arcus et al. 2005. Similar
to others in Mycobacterium tuberculosis e.g. Rv0277c,
Rv2530c,etc. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0749"
/db_xref="EnsemblGenomes-Tr:CCP43494"
/db_xref="GOA:P9WF75"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF75"
/protein_id="CCP43494.1"
/translation="MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVW
ASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPRHLMLLRKLCDEADAS
GDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL"
gene complement(841737..841874)
/locus_tag="Rv0749A"
CDS complement(841737..841874)
/codon_start=1
/transl_table=11
/locus_tag="Rv0749A"
/product="Hypothetical protein (fragment)"
/note="Rv0749A, len: 45 aa. Conserved hypothetical protein
(probably gene fragment), similar to part (aa 250-292) of
Rv2807|Z81331_12 from Mycobacterium tuberculosis (384
aa),FASTA scores: opt: 238, E(): 1.9e-13, (79.07% identity
in 43 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0749A"
/db_xref="EnsemblGenomes-Tr:CCP43495"
/db_xref="UniProtKB/TrEMBL:I6X9Q1"
/protein_id="CCP43495.1"
/translation="MVRKHAFHWRYDSTEELELLNQLWQLVSLRLNFFTPTKKALGFR
P"
gene 842033..842278
/locus_tag="Rv0750"
CDS 842033..842278
/codon_start=1
/transl_table=11
/locus_tag="Rv0750"
/product="Conserved hypothetical protein"
/note="Rv0750, (MTV041.24), len: 81 aa. Conserved
hypothetical protein, showing almost perfect overlap with
C-terminus of Rv0740|MTV041_14 conserved hypothetical
protein from Mycobacterium tuberculosis (175 aa), FASTA
scores: (93.8% identity in 81 aa overlap). Possible
duplication. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0750"
/db_xref="EnsemblGenomes-Tr:CCP43496"
/db_xref="UniProtKB/TrEMBL:O53813"
/protein_id="CCP43496.1"
/translation="MRAIVGDCVIHIMPMGTGVELSKLADLALDIGRSVGCSAYENDF
TLPDIPTQWRNQPLGWYTQGLAPYLPGLSDPKDAAEG"
gene complement(842347..843231)
/gene="mmsB"
/locus_tag="Rv0751c"
CDS complement(842347..843231)
/codon_start=1
/transl_table=11
/gene="mmsB"
/locus_tag="Rv0751c"
/product="Probable 3-hydroxyisobutyrate dehydrogenase MmsB
(hibadh)"
/note="Rv0751c, (MTV041.25c), len: 294 aa. Probable
mmsB,3-hydroxyisobutyrate dehydrogenase, highly similar to
others e.g. NP_102847.1|NC_002678 3-hydroxyisobutyrate
dehydrogenase from Mesorhizobium loti (294 aa);
NP_420167.1|NC_002696 3-hydroxyisobutyrate dehydrogenase
from Caulobacter crescentus (298 aa); A32867
3-hydroxyisobutyrate dehydrogenase from Rattus norvegicus
(346 aa); etc. Also similar to methylmalonate semialdehyde
dehydrogenases e.g. M84911|PSE MMSRAB_3 methylmalonate
semialdehyde dehydrogenase from Pseudomonas aeruginosa
(298 aa), FASTA scores: opt: 786, E(): 0, (45.8% identity
in 297 aa overlap). Also similar to 6-phosphogluconate
dehydrogenases from Mycobacterium tuberculosis e.g. Rv1122
and Rv1844c. Contains PS00895 3-hydroxyisobutyrate
dehydrogenase signature. Belongs to the
3-hydroxyisobutyrate dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv0751c"
/db_xref="EnsemblGenomes-Tr:CCP43497"
/db_xref="GOA:P9WNY5"
/db_xref="InterPro:IPR002204"
/db_xref="InterPro:IPR006115"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR011548"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR015815"
/db_xref="InterPro:IPR029154"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:5Y8G"
/db_xref="PDB:5Y8H"
/db_xref="PDB:5Y8I"
/db_xref="PDB:5Y8J"
/db_xref="PDB:5Y8K"
/db_xref="PDB:5Y8L"
/db_xref="PDB:5Y8M"
/db_xref="PDB:5Y8N"
/db_xref="PDB:5Y8O"
/db_xref="PDB:5Y8P"
/db_xref="UniProtKB/Swiss-Prot:P9WNY5"
/inference="protein motif:PROSITE:PS00895"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43497.1"
/translation="MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHG
VAVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREV
HALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGA
AGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCP
VPGPVPTSPANNDFKPGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADH
ADLDFSAVIHTLRARADA"
gene complement(843242..844414)
/gene="fadE9"
/locus_tag="Rv0752c"
CDS complement(843242..844414)
/codon_start=1
/transl_table=11
/gene="fadE9"
/locus_tag="Rv0752c"
/product="Probable acyl-CoA dehydrogenase FadE9"
/note="Rv0752c, (MTV041.26c), len: 390 aa. Probable
fadE9,acyl-CoA dehydrogenase, highly similar to many e.g.
NP_437985.1|NC_003078 putative acyl-CoA dehydrogenase
protein from Sinorhizobium meliloti (380 aa);
Z99123|BSUB0020_14 from Bacillus subtilis (379 aa), FASTA
scores: opt: 853, E(): 0, (39.8% identity in 384 aa
overlap); etc. Contains PS00072 Acyl-CoA dehydrogenases
signature 1, and PS00073 Acyl-Co Adehydrogenases signature
2. Belongs to the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0752c"
/db_xref="EnsemblGenomes-Tr:CCP43498"
/db_xref="GOA:I6Y4R2"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:I6Y4R2"
/inference="protein motif:PROSITE:PS00073"
/inference="protein motif:PROSITE:PS00072"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43498.1"
/translation="MFVLNDDERVIVETAAAFAGKRLAPHALEWDAAKHFPVDVLREA
AELGMAAIYCRDDVGGSGLRRLDGVRIFEQLAIADPVTAAFLSIHNMCAWMIDSFGTD
EQRKDWIPRLATMGVIASYCLTEPGAGSDAGALSTRAVRHGSGKGGDYVLDGVKQFIS
GAAASDVYVVMARTGAEGPRGVSAFIVEKGTPGLSFGAPEAKMGWHAQPTAQVVLDGV
RVPAEAMLGGADGEGAGFGIAMSGLNGGRLNIAACSLGGAQAAFDKAGAYVRDRQAFG
GSLLDEPTVRFTLADMATGLQTSRMLLWRAASALDDDDADKVELCAMAKRYVTDTCFE
VADQALQLHGGYGYLREYGLEKIVRDLRVHRILEGTNEIMRLVIGRAEAARFRATV"
gene complement(844421..845953)
/gene="mmsA"
/locus_tag="Rv0753c"
CDS complement(844421..845953)
/codon_start=1
/transl_table=11
/gene="mmsA"
/locus_tag="Rv0753c"
/product="Probable methylmalonate-semialdehyde
dehydrogenase MmsA (methylmalonic acid semialdehyde
dehydrogenase) (MMSDH)"
/note="Rv0753c, (MTV041.27c), len: 510 aa. Probable
mmsA,methylmalonic acid semialdehyde dehydrogenase, highly
similar to others e.g. NP_420115.1|NC_002696 putative
methylmalonate-semialdehyde dehydrogenase from Caulobacter
crescentus (499 aa); L48550|STMMSDA_1|CAB75315.1|AL139164
methylmalonic acid semialdehyde dehydrogenase from
Streptomyces coelicolor (500 aa), FASTA score: (51.6%
identity in 498 aa overlap);
M84911|PSEMMSRAB_2|NP_252260.1|NC_002516
methylmalonate-semialdehyde dehydrogenase from Pseudomonas
aeruginosa (497 aa), FASTA scores: opt: 1127, E():
0,(47.9% identity in 507 aa overlap); etc. Note that also
highly similar to malonic semialdehyde oxidative
decarboxylases e.g. NP_104968.1|NC_002678 malonic
semialdehyde oxidative decarboxylase from Mesorhizobium
loti (498 aa); NP_384832.1|NC_003047 putative malonic
semialdehyde oxidative decarboxylase protein from
Sinorhizobium meliloti (498 aa); etc. Contains PS00070
Aldehyde dehydrogenases cysteine active site. Belongs to
the aldehyde dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0753c"
/db_xref="EnsemblGenomes-Tr:CCP43499"
/db_xref="GOA:O53816"
/db_xref="InterPro:IPR010061"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016160"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="UniProtKB/TrEMBL:O53816"
/inference="protein motif:PROSITE:PS00070"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43499.1"
/translation="MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDI
DAAVASAVEAQKGWAAWNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGD
VQRGIEVIEFCLGIPHLLKGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWK
AGPALACGNAFVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPD
IKAVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYG
SAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALARV
RDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDANLEGGFFIGPTLFDHVAAHMSIY
TDEIFGPVLCMVRARDYEEALRLPSEHEYGNGVAIFTRDGDAARDFVSRVQVGMVGVN
VPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPT
MS"
gene 846159..847913
/gene="PE_PGRS11"
/locus_tag="Rv0754"
CDS 846159..847913
/codon_start=1
/transl_table=11
/gene="PE_PGRS11"
/locus_tag="Rv0754"
/product="PE-PGRS family protein PE_PGRS11"
/note="Rv0754, (MTV041.28), len: 584 aa. PE_PGRS11, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
similar to others e.g. AL0212|MTV008_46 from Mycobacterium
tuberculosis (1660 aa), FASTA score: (48.7% identity in
345 aa overlap); Z80225|MTCY441_4 from Mycobacterium
tuberculosis (778 aa), FASTA score: (41.6% identity in 442
aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0754"
/db_xref="EnsemblGenomes-Tr:CCP43500"
/db_xref="GOA:Q79FW5"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="UniProtKB/Swiss-Prot:Q79FW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43500.1"
/translation="MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAA
DEVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGAL
GSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTG
TAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMG
NGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGG
GGNGQSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGI
FDSQLIRTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWT
LGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFT
IGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALF
VDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDA
TGHPYLSGLPIGLPSLIP"
gene complement(848103..850040)
/gene="PPE12"
/locus_tag="Rv0755c"
CDS complement(848103..850040)
/codon_start=1
/transl_table=11
/gene="PPE12"
/locus_tag="Rv0755c"
/product="PPE family protein PPE12"
/note="Rv0755c, (MTV041.29), len: 645 aa. PPE12, Member of
the Mycobacterium tuberculosis PPE family, highly similar
to others e.g. Z82098|MTCY3C7_23 from Mycobacterium
tuberculosis (582 aa), FASTA scores: (56.1% identity in
636 aa overlap); Z92774|MTCY6G11_5 from Mycobacterium
tuberculosis (552 aa), FASTA scores: (55.8% identity in
590 aa overlap); etc. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0755c"
/db_xref="EnsemblGenomes-Tr:CCP43501"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI37"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43501.1"
/translation="MVGFAWLPPETNSLRMYLGAGSRPLLAAAGAWDGLAEELHAAAS
SFGSVTSELAGGAWQGPASAAMANAAGPYASWLTAAGAQAELAARQARAAAGAFEEAL
AGVVHPAVVQANRVRTWLLAVSNVFGQNAPAIAAMESTYEQMWAQDVAVMAGYHAASS
AAAAQLASWQPALPNINLGVGNIGNLNVGNGNTGDYNLGNGNLGNANFGGGNGSAFHG
QISSFNVGSGNIGNFNLGSGNGNVGIGPSSFNVGSGNIGNANVGGGNSGDNNFGFGNF
GNANIGIGNAGPNMSSPAVPTPGNGNVGIGNGGNGNFGGGNTGNANIGLGNVGDGNVG
FGNSGSYNFGFGNTGNNNIGIGLTGSNQIGFGGLNSGSGNIGFGNSGTGNIGFFNSGS
GNFGVGNSGVTNTGVANSGNINTGFGNSGFINTGFGNALSVNTGFGNSGQANTGIGNA
GDFNTGNFNGGIINTGSFNSGAFNSGSFNGGDANSGFLNSGLTNTGFANSGNINTGGF
NAGNLNTGFGNTTDGLGENSGFGNAGSGNSGFNNSGRGNSGAQNVGNLQISGFANSGQ
SVTGYNNSVSVTSGFGNKGTGLFSGFMSGFGNTGFLQSGFGNLEANPDNNSATSGFGN
SGKQDSGGFNSIDFVSGFFHR"
gene complement(850342..850527)
/locus_tag="Rv0755A"
CDS complement(850342..850527)
/codon_start=1
/transl_table=11
/locus_tag="Rv0755A"
/product="Putative transposase (fragment)"
/note="Rv0755A, len: 61 aa. Putative transposase (possibly
gene fragment), similar to C-terminal part of
Q9EZM2|ISMav2|AF286339_1 putative transposase from
Mycobacterium paratuberculosis (395 aa), FASTA scores:
opt: 284, E(): 5e-13, (83.02% identity in 53 aa overlap);
and to SCJ11.25c|Q9RI80 possible noncomposite transposon
transposase from Streptomyces coelicolor (283 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0755A"
/db_xref="EnsemblGenomes-Tr:CCP43502"
/db_xref="GOA:Q79FW3"
/db_xref="InterPro:IPR010921"
/db_xref="UniProtKB/TrEMBL:Q79FW3"
/protein_id="CCP43502.1"
/translation="MKELSVAEQRYQAVLAVISDGLSISQVAEKVGVSRQTLHTWLAR
YEAEGLDGLRIGTGTAL"
gene complement(850642..850713)
/gene="thrV"
tRNA complement(850642..850713)
/gene="thrV"
/product="tRNA-Thr"
/anticodon=(pos:complement(850679..850681),aa:Thr,seq:tgt)
/note="codon recognized: ACA; thrV, tRNA-Thr, anticodon
tgt, length = 72"
gene complement(850741..851466)
/locus_tag="Rv0756c"
CDS complement(850741..851466)
/codon_start=1
/transl_table=11
/locus_tag="Rv0756c"
/product="Unknown protein"
/note="Rv0756c, (MTCY369.01c), len: 241 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv0756c"
/db_xref="EnsemblGenomes-Tr:CCP43503"
/db_xref="UniProtKB/TrEMBL:P71813"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43503.1"
/translation="MNLGQTLVGIATWPARAGLAAADTGLNMAGAAVDMAKQALGDAG
GASGSTSMANMLGIDDTIARANRLARLLDDDMPLGRAIAPNGPMDRMLRPGGVVDLLT
QPGGLLDRLTAEGGAMQRALQPGGLADQLLAEDGLIERVLSEDGLADRLLAEGGLIDK
ITAKDGPLEQLADVADTLARLTPGMEALEPAIATLQDAVIALTMVVNPLSSIAERIPL
PGRRPARRSSSRSVRSQRVVDSE"
gene 851608..852351
/gene="phoP"
/locus_tag="Rv0757"
CDS 851608..852351
/codon_start=1
/transl_table=11
/gene="phoP"
/locus_tag="Rv0757"
/product="Possible two component system response
transcriptional positive regulator PhoP"
/note="Rv0757, (MTCY369.02), len: 247 aa. Possible
phoP,two component system response phosphate regulon
transcriptional regulator (see citations below), highly
similar to various transcriptional regulators e.g.
CAC32360.1|AL583945 putative two component system response
regulator from Streptomyces coelicolor (271 aa); T45446
probable two-component response regulator from
Mycobacterium leprae (253 aa); and similar to phoP
proteins e.g. P13792|PHOP_BACSU alkaline phosphatase
synthesis transcription regulatory protein from Bacillus
subtilis (240 aa), FASTA scores: opt: 594, E(): 2.3e-33,
(41.0% identity in 234 aa overlap); etc. Also highly
similar to Rv3765c from Mycobacterium tuberculosis (234
aa), Rv1033c (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa),
FASTA score: (45.4% identity in 229 aa overlap);
MTCY10G2_16 and MTU88959_1."
/db_xref="EnsemblGenomes-Gn:Rv0757"
/db_xref="EnsemblGenomes-Tr:CCP43504"
/db_xref="GOA:P71814"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="PDB:3R0J"
/db_xref="PDB:5ED4"
/db_xref="UniProtKB/TrEMBL:P71814"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43504.1"
/translation="MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQG
FEVYTATNGAQALDRARETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTARD
SLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDE
ETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYV
SYLRRKIDTGEKRLLHTLRGVGYVLREPR"
gene 852396..853853
/gene="phoR"
/locus_tag="Rv0758"
CDS 852396..853853
/codon_start=1
/transl_table=11
/gene="phoR"
/locus_tag="Rv0758"
/product="Possible two component system response sensor
kinase membrane associated PhoR"
/note="Rv0758, (MTCY369.03), len: 485 aa. Possible
phoR,two component system response phosphate sensor kinase
membrane-associated, highly similar to various sensor
kinases e.g. CAC32361.1|AL583945 putative two component
system histidine kinase from Streptomyces coelicolor (524
aa); NP_349365.1|NC_003030 Membrane-associated sensory
histidine kinase with HAMP domain from Clostridium
acetobutylicum (482 aa); and similar to phoP proteins e.g.
NP_372216.1|NC_002758 alkaline phosphatase synthesis
sensor protein from Staphylococcus aureus (554 aa);
P23545|PHOR_BACSU alkaline phosphatase synthesis sensor
from Bacillus subtilis (579 aa), FASTA scores: opt:
515,E(): 1.9e-25, (40.0% identity in 230 aa overlap); etc.
Also similar to proteins from Mycobacterium tuberculosis
e.g. MTCY20G9.16 FASTA scores: (34.5% identity in 264 aa
overlap), MTU88959_2 (509 aa), MTCY10G2_17, etc."
/db_xref="EnsemblGenomes-Gn:Rv0758"
/db_xref="EnsemblGenomes-Tr:CCP43505"
/db_xref="GOA:P71815"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="PDB:5UKV"
/db_xref="PDB:5UKY"
/db_xref="UniProtKB/TrEMBL:P71815"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43505.1"
/translation="MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTS
RIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTAI
PAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLL
QVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRL
SLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYR
QGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDA
RAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEG
DDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAV
TVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP"
gene complement(853825..854157)
/locus_tag="Rv0759c"
CDS complement(853825..854157)
/codon_start=1
/transl_table=11
/locus_tag="Rv0759c"
/product="Conserved hypothetical protein"
/note="Rv0759c, (MTCY369.04c), len: 110 aa. Conserved
hypothetical protein, highly similar (but shorter 45 aa in
N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A
hypothetical hit-like protein from Mycobacterium leprae
(155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity
in 150 aa overlap). Also highly similar (but N-terminus
always shorter) to hit-like proteins and protein kinase
inhibitors e.g. AAF72728.1|AF265258_1|AF265258 hit-like
protein from Rhodococcus sp. (141 aa);
NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI)
from Borrelia burgdorferi (149 aa) ;
P94252|YHIT_BORBU|BB0379 hypothetical hit-like protein
from Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689
hit (histidine triad) family protein from Thermoplasma
volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C
inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125
aa),FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity
in 111 aa overlap); etc. Also shows similarity with
Rv2613c|MTCY01A10.20A conserved hypothetical protein from
Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20
hypothetical hit-like protein (144 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0759c"
/db_xref="EnsemblGenomes-Tr:CCP43506"
/db_xref="GOA:P9WML3"
/db_xref="InterPro:IPR001310"
/db_xref="InterPro:IPR011146"
/db_xref="InterPro:IPR019808"
/db_xref="InterPro:IPR036265"
/db_xref="UniProtKB/Swiss-Prot:P9WML3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43506.1"
/translation="MAFLTIEPMTQGHTLVVPRAEIDHWQNVDPALFGRVMSVSQLIG
KAVCRAFSTQRAGMIIAGLEVPHLHIHVFPTRSLSDFGFANVDRNPSPGSLDEAQAKI
RAALAQLA"
gene complement(854267..854686)
/locus_tag="Rv0760c"
CDS complement(854267..854686)
/codon_start=1
/transl_table=11
/locus_tag="Rv0760c"
/product="Conserved protein"
/note="Rv0760c, (MTCY369.05), len: 139 aa. Conserved
protein, similar to N-terminal part of Rv2042c conserved
hypothetical protein from Mycobacterium tuberculosis (265
aa), FASTA scores: opt: 150, E(): 4.1e-05, (28.7% identity
in 136 aa overlap). Belongs to the NTF2-like (nuclear
transport factor 2) protein superfamiily."
/db_xref="EnsemblGenomes-Gn:Rv0760c"
/db_xref="EnsemblGenomes-Tr:CCP43507"
/db_xref="InterPro:IPR002075"
/db_xref="InterPro:IPR032710"
/db_xref="UniProtKB/TrEMBL:I6WZD7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43507.1"
/translation="MTQTTQSPALIASQSSWRCVQAHDREGWLALMADDVVIEDPIGK
SVTNPDGSGIKGKEAVGAFFDTHIAANRLTVTCEETFPSSSPDEIAHILVLHSEFDGG
FTSEVRGVFTYRVNKAGLITNMRGYWNLDMMTFGNQE"
gene complement(854699..855826)
/gene="adhB"
/locus_tag="Rv0761c"
CDS complement(854699..855826)
/codon_start=1
/transl_table=11
/gene="adhB"
/locus_tag="Rv0761c"
/product="Possible zinc-containing alcohol dehydrogenase
NAD dependent AdhB"
/note="Rv0761c, (MTCY369.06c), len: 375 aa. Possible
adhB,zinc-containing alcohol dehydrogenase
NAD-dependent,similar to others e.g. AAC15839.1|AF060871_4
hypothetical alcohol dehydrogenase from Rhodococcus
rhodochrous (370 aa), FASTA scores: opt: 1234, E(): 0,
(46.8% identity in 370 aa overlap); P80468|ADH2_STRCA
alcohol dehydrogenase II from Struthio camelus (Ostrich)
(379 aa); Q03505|ADH1_RABIT alcohol dehydrogenase alpha
chain from Oryctolagus cuniculus (Rabbit) (374 aa), FASTA
scores: opt: 872, E(): 0, (39.1% identity in 379 aa
overlap); etc. Also similar to adhD alcohol dehydrogenase
from Mycobacterium tuberculosis (368 aa). Contains PS00059
Zinc-containing alcohol dehydrogenases signature. Belongs
to the zinc-containing alcohol dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv0761c"
/db_xref="EnsemblGenomes-Tr:CCP43508"
/db_xref="GOA:P9WQC7"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR023921"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WQC7"
/inference="protein motif:PROSITE:PS00059"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43508.1"
/translation="MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDH
HLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSCQAGM
RNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVP
FEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVE
PVEWKRDQALKFGATHVYPDINAALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTI
TAKGGTCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAG
KLNLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR"
gene complement(855925..856470)
/locus_tag="Rv0762c"
CDS complement(855925..856470)
/codon_start=1
/transl_table=11
/locus_tag="Rv0762c"
/product="Conserved hypothetical protein"
/note="Rv0762c, (MTCY369.07c), len: 181 aa. Conserved
hypothetical protein, showing weak similarity to
D90907_77|P73575 hypothetical 31.3KD protein from
Synechocystis sp, FASTA scores: E(): 0.0012, (30.4%
identity in 92 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0762c"
/db_xref="EnsemblGenomes-Tr:CCP43509"
/db_xref="InterPro:IPR032710"
/db_xref="UniProtKB/TrEMBL:I6XW93"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43509.1"
/translation="MAGYPRDELEDVVHRWLQANRTAERRGDWTLLADFYTDDATYGW
NVGPNEDVMCVGIDEIRDIALGQEMDGLQGWRYPYQRVVIDEKQGEVVGFWKQVATDA
NGAEQEVYGIGGSWFRYAGGGKWNWQRDFFDFGHVSALYLELIKAGKLSPGMQKRIER
AVSGNKVPGYYPLGKTPVPLW"
gene complement(856473..856679)
/locus_tag="Rv0763c"
CDS complement(856473..856679)
/codon_start=1
/transl_table=11
/locus_tag="Rv0763c"
/product="Possible ferredoxin"
/note="Rv0763c, (MTCY369.08c), len: 68 aa. Possible
ferredoxin, similar to others and related proteins e.g.
P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from
Streptomyces griseolus (68 aa);
AAK31349.1|AF350429_2|AF350429 putative ferredoxin from
Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043
phthalate dioxygenase ferredoxin subunit from Arthrobacter
keyseri (64 aa); etc. Probably involved in electron
transport for cytochrome P-450 system e.g. downstream ORF
Rv0764c|MTCY369.09c probable cytochrome P450 51 from
Mycobacterium tuberculosis (451 aa), FASTA scores: opt:
137, E(): 0.00013, (36.4% identity in 66 aa overlap). Also
similar to putative ferredoxins Rv3503c and Rv1786 from
Mycobacterium tuberculosis. Could belong to the bacterial
type ferredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv0763c"
/db_xref="EnsemblGenomes-Tr:CCP43510"
/db_xref="UniProtKB/TrEMBL:P71820"
/protein_id="CCP43510.1"
/translation="MGYRVEADRDLCQGHAMCELEAPEYFRVPKRGQVEILDPEPPEE
ARGVIKHAVWACPTQALSIRETGE"
gene complement(856682..858037)
/gene="cyp51"
/locus_tag="Rv0764c"
CDS complement(856682..858037)
/codon_start=1
/transl_table=11
/gene="cyp51"
/locus_tag="Rv0764c"
/product="Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1)
(sterol 14-alpha demethylase) (lanosterol 14-alpha
demethylase) (P450-14DM)"
/note="Rv0764c, (MT0788, MTCY369.09c), len: 451 aa.
Cyp51,cytochrome P450 51 (sterol 14-alpha demethylase),
similar to others e.g. Q16850|CP51_HUMAN cytochrome P450
51 (CYPL1) (P450L1) (sterol 14-alpha demethylase)
(lanosterol 14-alpha demethylase) from Homo sapiens (509
aa), FASTA scores: opt: 848, E(): 0, (33.9% identity in
439 aa overlap); NP_172633.1|NC_003070 putative
obtusifoliol 14-alpha demethylase from Arabidopsis
thaliana (488 aa); P93596|CP51_WHEAT cytochrome P450 51
(CYPL1) (P450-L1A1) (obtusifoliol 14-alpha demethylase)
from Triticum aestivum (453 aa); etc. Also similar to many
other Mycobacterium tuberculosis cytochromes P450 e.g.
Rv1394c, FASTA score: (22.5% identity in 444 aa overlap).
Contains PS00086 Cytochrome P450 cysteine heme-iron ligand
signature. Belongs to the cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv0764c"
/db_xref="EnsemblGenomes-Tr:CCP43511"
/db_xref="GOA:P9WPP9"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002403"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:1E9X"
/db_xref="PDB:1EA1"
/db_xref="PDB:1H5Z"
/db_xref="PDB:1U13"
/db_xref="PDB:1X8V"
/db_xref="PDB:2BZ9"
/db_xref="PDB:2CI0"
/db_xref="PDB:2CIB"
/db_xref="PDB:2VKU"
/db_xref="PDB:2W09"
/db_xref="PDB:2W0A"
/db_xref="PDB:2W0B"
/db_xref="UniProtKB/Swiss-Prot:P9WPP9"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43511.1"
/translation="MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQ
LAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN
AALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQ
LDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPT
DKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHR
DAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV
QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRH
RCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG
V"
gene complement(858037..858864)
/locus_tag="Rv0765c"
CDS complement(858037..858864)
/codon_start=1
/transl_table=11
/locus_tag="Rv0765c"
/product="Probable oxidoreductase"
/note="Rv0765c, (MTCY369.10c), len: 275 aa. Probable
oxidoreductase, similar others e.g. P39071|DHBA_BACSU
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from
Bacillus subtilis (261 aa), FASTA scores: opt: 385, E():
1.8e-17, (30.6% identity in 252 aa overlap);
AAF81239.1|AF263012 putative beta-ketoacyl reductase from
Streptomyces griseus (274 aa); NP_436514.1|NC_003037
putative oxidoreductase from Sinorhizobium meliloti (240
aa); etc. Also similar to several other oxidoreductases
from Mycobacterium tuberculosis e.g.
Rv1544|MTCY48.21,FASTA score: (32.6% identity in 267 aa
overlap); etc. Contains PS00061 Short-chain alcohol
dehydrogenase family signature."
/db_xref="EnsemblGenomes-Gn:Rv0765c"
/db_xref="EnsemblGenomes-Tr:CCP43512"
/db_xref="GOA:I6WZD9"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6WZD9"
/inference="protein motif:PROSITE:PS00061"
/protein_id="CCP43512.1"
/translation="MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRM
DKLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQTVEALGEVELLVSSAGDMLPGQ
LHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYG
AAKAGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQA
RHNYFLRPSDLARAIAFVAETPRGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG"
gene complement(858864..860072)
/gene="cyp123"
/locus_tag="Rv0766c"
CDS complement(858864..860072)
/codon_start=1
/transl_table=11
/gene="cyp123"
/locus_tag="Rv0766c"
/product="Probable cytochrome P450 123 Cyp123"
/note="Rv0766c, (MT0790, MTCY369.11c), len: 402 aa.
Probable cyp123, cytochrome P-450, similar to others e.g.
P33271|CPXK_SACER cytochrome P-450 107B1 from
Saccharopolyspora erythraea (405 aa), FASTA scores: opt:
770, E(): 0, (36.9% identity in 406 aa overlap); T36526
probable cytochrome P450 hydroxylase from Streptomyces
coelicolor (411 aa); P27632|CPXM_BACSU cytochrome P450 109
from Bacillus subtilis (405 aa); etc. Also similar to
several other cytochromes P-450 from Mycobacterium
tuberculosis e.g. Rv1256c|MTCY50.26 (405 aa), FASTA score:
(35.2% identity in 389 aa overlap); etc. Contains PS00086
Cytochrome P450 cysteine heme-iron ligand signature.
Belongs to the cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv0766c"
/db_xref="EnsemblGenomes-Tr:CCP43513"
/db_xref="GOA:P9WPP5"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPP5"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43513.1"
/translation="MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNF
WAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVS
KGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDR
ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAE
LDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWV
EETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGR
EIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGF
AHLPISVQAR"
gene complement(860069..860710)
/locus_tag="Rv0767c"
CDS complement(860069..860710)
/codon_start=1
/transl_table=11
/locus_tag="Rv0767c"
/product="Conserved hypothetical protein"
/note="Rv0767c, (MTCY369.12c), len: 213 aa. Conserved
hypothetical protein, showing weak similarity with
AL133220|SCC75A_26 hypothetical protein from Streptomyces
coelicolor (215 aa), FASTA scores: opt: 152, E():
0.0048,(28.4% identity in 204 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0767c"
/db_xref="EnsemblGenomes-Tr:CCP43514"
/db_xref="GOA:P9WMD7"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="UniProtKB/Swiss-Prot:P9WMD7"
/protein_id="CCP43514.1"
/translation="MSSDVLVTTPAQRQTEPHAEAVSRNRRQQATFRKVLAAAMATLR
EKSYADLTVRLVAARAKVAPATAYTYFSSKNHLIAEVYLDLVRQVPCVTDVNVPMPIR
VTSSLRHLALVVADEPEIGAACTAALLDGGADPAVRAVRDRIGAEIHRRITSAIGPGA
DPGTVFALEMAFFGALVQAGSGTFTYHEIADRLGYVVGLILAGANEPSTGGSE"
gene 860912..862381
/gene="aldA"
/locus_tag="Rv0768"
CDS 860912..862381
/codon_start=1
/transl_table=11
/gene="aldA"
/locus_tag="Rv0768"
/product="Probable aldehyde dehydrogenase NAD dependent
AldA (aldehyde dehydrogenase [NAD+])"
/note="Rv0768, (MTCY369.13), len: 489 aa. Probable
aldA,NAD-dependent aldehyde dehydrogenase, highly similar
to others e.g. AAL14238.1|AY052630 6-oxolauric acid
dehydrogenase from Rhodococcus ruber (474 aa);
NP_285450.1|NC_001264 aldehyde dehydrogenase from
Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570
NADP-dependent aldehyde dehydrogenase from Bacillus
halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde
dehydrogenase precursor from Atriplex hortensis (Mountain
spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6%
identity in 486 aa overlap); etc. Also highly similar to
Rv0223c aldehyde dehydrogenase from Mycobacterium
tuberculosis (487 aa). Contains PS00687 Aldehyde
dehydrogenases glutamic acid active site. Belongs to the
aldehyde dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0768"
/db_xref="EnsemblGenomes-Tr:CCP43515"
/db_xref="GOA:I6X9R9"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR026460"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/TrEMBL:I6X9R9"
/inference="protein motif:PROSITE:PS00687"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43515.1"
/translation="MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADA
EDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELRELTISEVGAPRML
TASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWN
FPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSH
ALGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAA
ASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGP
LISARQRDRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGLTNDARVAREE
IFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVNGGV
WYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN"
gene 862412..863158
/locus_tag="Rv0769"
CDS 862412..863158
/codon_start=1
/transl_table=11
/locus_tag="Rv0769"
/product="Probable dehydrogenase/reductase"
/note="Rv0769, (MTCY369.14), len: 248 aa. Probable
dehydrogenase/reductase, similar to others, especially
short-chain type dehydrogenases/reductases and
3-oxoacyl-(acyl-carrier protein) reductases e.g.
NP_106890.1|NC_002678 probable short-chain type
dehydrogenase/reductase from Mesorhizobium loti (374 aa);
NP_243357.1|NC_002570 3-oxoacyl-(acyl-carrier protein)
reductase from Bacillus halodurans (246 aa);
P28643|FABG_CUPLA 3-oxoacyl-[acyl-carrier protein]
reductase from Cuphea lanceolata (320 aa);
P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase
from Escherichia coli (255 aa), FASTA scores: opt: 536,
E(): 6.5e-27, (37.7% identity in 247 aa overlap); etc.
Also similar to others from Mycobacterium tuberculosis
e.g. MTCY02B10.14, FASTA score: (33.7% identity in 249 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0769"
/db_xref="EnsemblGenomes-Tr:CCP43516"
/db_xref="GOA:P9WGQ9"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGQ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43516.1"
/translation="MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAV
AKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLT
VPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGV
NGLTQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDL
VGMCLFLLSDSASWITGQIFNVDGGQIIRS"
repeat_region 863155..863255
/note="101 bp Mycobacterial Interspersed Repetitive
Unit,Class I"
gene 863256..864143
/locus_tag="Rv0770"
CDS 863256..864143
/codon_start=1
/transl_table=11
/locus_tag="Rv0770"
/product="Probable dehydrogenase/reductase"
/note="Rv0770, (MTCY369.15), len: 295 aa. Probable
dehydrogenase/reductase, 3-hydroxyisobutyrate
dehydrogenase family, possibly 3-hydroxyisobutyrate
dehydrogenase or 2-hydroxy-3-oxopropionate reductase,
similar to others e.g. P23523|GARR_ECOLI
2-hydroxy-3-oxopropionate reductase (tartronate
semialdehyde reductase) (TSAR) from Escherichia coli
strain K12 (294 aa), FASTA scores: opt: 469, E(): 6.7e-22,
(34.4% identity in 282 aa overlap); P28811|MMSB_PSEAE
3-hydroxyisobutyrate dehydrogenase (hibadh) from
Pseudomonas aeruginosa (298 aa), FASTA scores: opt: 439,
E(): 4.3e-20, (34.9% identity in 269 aa overlap); etc.
Also similar to others from Mycobacterium tuberculosis
e.g. Rv1122 and Rv1844c. Seems to belong to the
3-hydroxyisobutyrate dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv0770"
/db_xref="EnsemblGenomes-Tr:CCP43517"
/db_xref="GOA:P9WNY3"
/db_xref="InterPro:IPR002204"
/db_xref="InterPro:IPR006115"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR015815"
/db_xref="InterPro:IPR029154"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WNY3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43517.1"
/translation="MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMA
PFVEGGATAAASVSDVAEADIISITVFDDAQVSSVITADNGLATHAKPGTIVAIHSTI
ADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADDEAFQRIKEPFSRWA
SLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEACGLDLVALGKVVRHSDSFT
GGAGAIMFRNTTAPMEPADPLRPLLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQ
RLAAGLGVPHPDTEPAKET"
gene 864140..864574
/locus_tag="Rv0771"
CDS 864140..864574
/codon_start=1
/transl_table=11
/locus_tag="Rv0771"
/product="Possible 4-carboxymuconolactone decarboxylase
(CMD)"
/note="Rv0771, (MTCY369.16), len: 144 aa. Possible
4-carboxymuconolactone decarboxylase, showing similarity
with other carboxymuconolactone decarboxylases e.g.
AAD39557.1|AF031417 PcaC-like protein from Pseudomonas
putida (130 aa); P20370|DC4C_ACICA 4-carboxymuconolactone
decarboxylase (CMD) from Acinetobacter sp. ADP1 (134
aa),FASTA scores: opt: 174, E(): 0.00075, (31.4% identity
in 121 aa overlap); C-terminus of NP_421214.1|NC_002696
3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone
decarboxylase from Caulobacter crescentus (393 aa);
C-terminus of T47115 probable 4-carboxymuconolactone
decarboxylase / 3-oxoadipate enol-lactone hydrolase from
Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative
gamma carboxymuconolactone decarboxylase from Yersinia
pestis (131 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0771"
/db_xref="EnsemblGenomes-Tr:CCP43518"
/db_xref="GOA:I6Y4S7"
/db_xref="InterPro:IPR003779"
/db_xref="InterPro:IPR029032"
/db_xref="UniProtKB/TrEMBL:I6Y4S7"
/protein_id="CCP43518.1"
/translation="MMDELRRTGLDKMNEVYAWDMPDMPGEFFALTVDHLFGRIWTRP
GLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELTIDELRELAVFITHYVGFPLG
SRLNSAIERVAAKRKQAAENGSLPDTKANVAEVLAKESGKSS"
gene 864586..865854
/gene="purD"
/locus_tag="Rv0772"
CDS 864586..865854
/codon_start=1
/transl_table=11
/gene="purD"
/locus_tag="Rv0772"
/product="Probable phosphoribosylamine--glycine ligase
PurD (GARS) (glycinamide ribonucleotide synthetase)
(phosphoribosylglycinamide synthetase)
(5'-phosphoribosylglycinamide synthetase)"
/note="Rv0772, (MTCY369.17), len: 422 aa. Probable
purD,phosphoribosylamine--glycine ligase, equivalent to
Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08
phosphoribosylamine--glycine ligase from Mycobacterium
leprae (422 aa), FASTA scores: opt: 2272, E(): 0, (81.8%
identity in 422 aa overlap). Also highly similar to others
e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine
ligase from Streptomyces coelicolor (416 aa);
P1564|PUR2_ECOLI phosphoribosylamine--glycine ligase from
Escherichia coli (429 aa), FASTA scores: opt: 1039, E():
0, (42.7% identity in 431 aa overlap); etc. Belongs to the
GarS family."
/db_xref="EnsemblGenomes-Gn:Rv0772"
/db_xref="EnsemblGenomes-Tr:CCP43519"
/db_xref="GOA:P9WHM9"
/db_xref="InterPro:IPR000115"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR013815"
/db_xref="InterPro:IPR016185"
/db_xref="InterPro:IPR020559"
/db_xref="InterPro:IPR020560"
/db_xref="InterPro:IPR020561"
/db_xref="InterPro:IPR020562"
/db_xref="InterPro:IPR037123"
/db_xref="UniProtKB/Swiss-Prot:P9WHM9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43519.1"
/translation="MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQH
DVDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPGKDAARIEGS
KAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDPAWVVKDDRLAAGKGVVV
TADRDVARAHGAALLEAGHPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGED
DTGLNTGGMGAYAPLPWLPDNIYREVVSRIVEPVAAELVRRGSSFCGLLYVGLAITAR
GPAVVEFNCRFGDPETQAVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLA
AENYPGRPRVGDVVVGSEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAH
AYEILSSIRLPGGHFRSDIGLRAAEGKISV"
gene complement(865851..867389)
/gene="ggtA"
/locus_tag="Rv0773c"
CDS complement(865851..867389)
/codon_start=1
/transl_table=11
/gene="ggtA"
/locus_tag="Rv0773c"
/product="Probable bifunctional acylase GgtA:
cephalosporin acylase (GL-7ACA acylase) +
gamma-glutamyltranspeptidase (GGT)"
/note="Rv0773c, (MTCY369.18), len: 512 aa. Probable
ggtA,bifunctional acylase including cephalosporin acylase,
and gamma-glutamyl transpeptidase; highly similar to
others e.g. NP_295247.1|NC_001263 cephalosporin acylase
from Deinococcus radiodurans (535 aa);
NP_248854.1|NC_002516 probable
gamma-glutamyltranspeptidase from Pseudomonas aeruginosa
(538 aa); P15557|PAC1_PSES3 acylase ACY 1 [includes:
cephalosporin acylase (GL-7ACA acylase);
gamma-glutamyltranspeptidase (GGT)] from Pseudomonas sp.
strain SE83 (558 aa), FASTA scores: opt: 784, E():
0,(34.2% identity in 526 aa overlap);
NP_391491.1|NC_000964|Z93767|BSZ93767_6|O0521 protein
similar to gamma-glutamyltransferase from Bacillus
subtilis (525 aa), FASTA scores: opt: 1169, E(): 0, (40.1%
identity in 516 aa overlap); etc. Also similar to
Rv2394|ggtB from Mycobacterium tuberculosis. Member of
GL-7ACA acylases and to GGT group."
/db_xref="EnsemblGenomes-Gn:Rv0773c"
/db_xref="EnsemblGenomes-Tr:CCP43520"
/db_xref="GOA:I6X9S5"
/db_xref="InterPro:IPR000101"
/db_xref="InterPro:IPR029055"
/db_xref="UniProtKB/TrEMBL:I6X9S5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43520.1"
/translation="MPILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVV
EPVSNGIGSDAFSIVWDGQKLHGLNASGRSPSAWTPEYFGGNAVPVLGWNSVTVPGAV
SAWVELHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFM
PGGRAPKPGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLA
AHRVDWVDTITGTYRGYTIHQIPPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQI
EALKLAFADAQACVADIDYMPVHPKRLLDKEYLRQRATLIDPKRAMPAATGIPRGGTV
YLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSDFTVVPRHPNRVGPRKRP
YHTIIPGFVTRDGAPVMSFGVMGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVN
GMRVSFENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAASDPRRDGQ
AAAC"
gene complement(867440..868351)
/locus_tag="Rv0774c"
CDS complement(867440..868351)
/codon_start=1
/transl_table=11
/locus_tag="Rv0774c"
/product="Probable conserved exported protein"
/note="Rv0774c, (MTCY369.19c), len: 303 aa. Possible
conserved exported protein with hydrophobic region near
N-terminus, highly similar, except in N-terminus, to
Rv0519c|Z97831|MTY20G10.09c|O33364 hypothetical protein
from Mycobacterium tuberculosis (300 aa), FASTA scores:
opt: 1092, E(): 0, (57.9% identity in 299 aa overlap).
Contains PS00061 Short-chain alcohol dehydrogenase family
signature, and PS00120 Lipases, serine active site. So
could be a lipase. Start changed since first submission
(-9 aa). Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0774c"
/db_xref="EnsemblGenomes-Tr:CCP43521"
/db_xref="GOA:I6Y8R4"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6Y8R4"
/inference="protein motif:PROSITE:PS00061"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43521.1"
/translation="MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPA
AAIGTNVPLAPTPALDPAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRP
VIALHGLGGSASAVMDGGVEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAM
VLNELIPLLDTQRLDTSRVAFLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAG
SVAPGSFDGPDDWSANSVFGLPALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGF
SPGGHNGGFWSAQLPAELTWFAPLLTG"
gene 868407..869030
/locus_tag="Rv0775"
CDS 868407..869030
/codon_start=1
/transl_table=11
/locus_tag="Rv0775"
/product="Conserved hypothetical protein"
/note="Rv0775, (MTCY369.20), len: 207 aa. Conserved
hypothetical protein, showing some similarity to other
proteins e.g. ECAE000186_11|MG1655 hypothetical protein
from Escherichia coli strain K-12 (178 aa), FASTA scores:
E(): 6.4e-05, (27.2% identity in 147 aa overlap);
P41037|BIH_ECOLI hypothetical transcriptional regulator
from Escherichia coli (103 aa), FASTA scores: opt:
138,E(): 0.003, (30.9% identity in 97 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0775"
/db_xref="EnsemblGenomes-Tr:CCP43522"
/db_xref="GOA:P71830"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR041583"
/db_xref="UniProtKB/TrEMBL:P71830"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43522.1"
/translation="MGVTAAVTPKGERRRYALVSAAAELLGEGGFEAVRHRAVARRAG
LPLASTTYYFSSLDDLIARAVEHIGMIEVAQLRARVSALSRRRRGPETTAVVLVDLLV
GEMSSPGLAEQLISRYERHIACTRLPDLRESMRRSLRQRAEAVAEAIERSGRSAQIEL
VCTLICAVDGSVVSALVEGRDPRAAALATVVDLIDVLAPVDQRPVPF"
gene complement(868984..869763)
/locus_tag="Rv0776c"
CDS complement(868984..869763)
/codon_start=1
/transl_table=11
/locus_tag="Rv0776c"
/product="Conserved hypothetical protein"
/note="Rv0776c, (MTCY369.21a), len: 259 aa. Conserved
hypothetical protein, similar (except first 50 aa) to
P72737|D90900_57 hypothetical protein from Synechocystis
sp. strain PCC 6803 (261 aa), FASTA scores: opt: 337, E():
1.7e-15, (30.5% identity in 266 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0776c"
/db_xref="EnsemblGenomes-Tr:CCP43523"
/db_xref="InterPro:IPR007362"
/db_xref="InterPro:IPR008306"
/db_xref="UniProtKB/TrEMBL:I6Y4S9"
/protein_id="CCP43523.1"
/translation="MYFVGVDLAWAGRNPTGVAAVDADGCLVGVGAARDDASVLAALR
PYVVGDCLVAFDAPLVVANRTGQRPAEAALNRDFRQFEAGAYPANTEKPEFADVPRAA
RLARQLALDMDPLSSATRRAIEVYPHPATVALFRLPRALKYKAKPGRSVDLLKSELLR
LMDGVEGLAQAGVRMQVAGQPDWVSLRRQVTVAQRKSDLRAAEDPIDAVVCAYVALYA
QRRPADVTIYGDFTTGYIVTPSLPTDFRTAPDAGRRARARR"
gene 870008..871426
/gene="purB"
/locus_tag="Rv0777"
CDS 870008..871426
/codon_start=1
/transl_table=11
/gene="purB"
/locus_tag="Rv0777"
/product="Probable adenylosuccinate lyase PurB
(adenylosuccinase) (ASL) (ASASE)"
/note="Rv0777, (MTCY369.21b), len: 472 aa. Probable
purB,adenylosuccinate lyase, equivalent (but shorter 15
aa) to MLCB5.13|Z95151|g2076607|PURB adenylosuccinate
lyase from Mycobacterium leprae (487 aa), FASTA scores:
opt: 2640,E(): 0, (86.7% identity in 472 aa overlap). More
similar to eukaryotic adenylosuccinate lyases than to
prokaryotic adenylosuccinate lyases e.g. P54822|PUR8_MOUSE
adenylosuccinate lyase from Mus musculus (484 aa), FASTA
scores: opt: 762, E(): 0, (32.4% identity in 445 aa
overlap); CAB99134.1|AL390188 putative adenylosuccino
lyase (fragment) from Streptomyces coelicolor (362 aa);
etc. Contains PS00163 Fumarate lyases signature. Belongs
to the lyase 1 family, adenylossucinate lyase subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0777"
/db_xref="EnsemblGenomes-Tr:CCP43524"
/db_xref="GOA:I6XWA1"
/db_xref="InterPro:IPR000362"
/db_xref="InterPro:IPR004769"
/db_xref="InterPro:IPR008948"
/db_xref="InterPro:IPR019468"
/db_xref="InterPro:IPR020557"
/db_xref="InterPro:IPR022761"
/db_xref="UniProtKB/TrEMBL:I6XWA1"
/inference="protein motif:PROSITE:PS00163"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43524.1"
/translation="MSIPNVLATRYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELG
VAVADSVLADYERVVDDVDLASISARERVLRHDVKARIEEFNALAGHEHVHKGMTSRD
LTENVEQLQIRRSLEVIFAHGVAAVARLAERAVSYRDLIMAGRSHNVAAQATTLGKRF
ASAAQEMMIALRRLRELIDRYPLRGIKGPMGTGQDMLDLLGGDRAALADLERRVADFL
GFATVFNSVGQVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELATEGFAPGQVG
SSAMPHKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVALPDSFF
AVDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAVRAGMGRESAHRLIS
EHAVATALAMREHGAEPDLLDRLAADPRLTLGRDALEAALADKKAFAGAAGDQVDDVV
AMVDALVSRYPDAAKYTPGAIL"
gene 871431..872675
/gene="cyp126"
/locus_tag="Rv0778"
CDS 871431..872675
/codon_start=1
/transl_table=11
/gene="cyp126"
/locus_tag="Rv0778"
/product="Possible cytochrome P450 126 Cyp126"
/note="Rv0778, (MT0802, MTCY369.22), len: 414 aa. Possible
cyp126, cytochrome P-450, similar to other cytochromes and
related proteins e.g. AAG29781.1|AF235050_4|AF235050
cytochrome P-450 from Streptomyces rishiriensis (407 aa);
Q59723|PSECYTOCHR_1 cytochrome p-450 linalool
8-monooxygenase (lin C) from Pseudomonas incognita (406
aa), FASTA scores: opt: 769, E(): 0, (37.0% identity in
411 aa overlap); etc. Also similar to others from
Mycobacterium tuberculosis e.g. Rv0766c, Rv2266, Rv3545c,
etc. Contains PS00086 Cytochrome P450 cysteine heme-iron
ligand signature."
/db_xref="EnsemblGenomes-Gn:Rv0778"
/db_xref="EnsemblGenomes-Tr:CCP43525"
/db_xref="GOA:P9WPN9"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:5LI6"
/db_xref="PDB:5LI7"
/db_xref="PDB:5LI8"
/db_xref="PDB:5LIE"
/db_xref="UniProtKB/Swiss-Prot:P9WPN9"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43525.1"
/translation="MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEH
TPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPR
HTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICI
LLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPA
DDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQL
QTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRD
PSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEP
AEWTRSNRHTGIRHLVVELRGG"
gene complement(872672..873292)
/locus_tag="Rv0779c"
CDS complement(872672..873292)
/codon_start=1
/transl_table=11
/locus_tag="Rv0779c"
/product="Possible conserved transmembrane protein"
/note="Rv0779c, (MTCY369.23c), len: 206 aa. Possible
conserved transmembrane protein, equivalent to
Z95151|MLCB5_14 O05747 conserved hypothetical protein from
Mycobacterium leprae (206 aa), FASTA scores: opt: 902,
E(): 0, (67.2% identity in 204 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0779c"
/db_xref="EnsemblGenomes-Tr:CCP43526"
/db_xref="GOA:P71833"
/db_xref="UniProtKB/TrEMBL:P71833"
/protein_id="CCP43526.1"
/translation="MRSRFLPYATTPGRLLAQLISDITVAVWTTLWMLVGLAVHDAIS
IIGEAGRQIEIGSHGIAGNLAAAGQDAQRIPVVGDALSNPITAASQAALDIAGAGHNL
DTTAGWLAVVLALAVAATPILAVAMPWLFLRLRFCRRKWTVTTLAATPAGRQLLALRA
LANRPPGKLAAVSTDPVGAWRREDPATMRALAALELRAAGIPLRGD"
gene 873343..874236
/gene="purC"
/locus_tag="Rv0780"
CDS 873343..874236
/codon_start=1
/transl_table=11
/gene="purC"
/locus_tag="Rv0780"
/product="Phosphoribosylaminoimidazole-succinocarboxamide
synthase PurC (SAICAR synthetase)"
/note="Rv0780, (MTCY369.24), len: 297 aa.
PurC,phosphoribosylaminoimidazole- succinocarboxamide
synthase (see citations below), equivalent to
MTU34957_1|PURC phosphoribosylaminoimidazole-
succinocarboxamide synthase from Mycobacterium leprae (297
aa), FASTA scores: opt: 1986, E(): 0, (99.3% identity in
297 aa overlap). Also similar to others e.g.
CAB56351.1|AL118514
phosphoribosylaminoimidazole-succinocarboxamide synthase
from Streptomyces coelicolor (299 aa); etc. Contains
PS01058 SAICAR synthetase signature 2. Belongs to the
SAICAR synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv0780"
/db_xref="EnsemblGenomes-Tr:CCP43527"
/db_xref="GOA:P9WHN1"
/db_xref="InterPro:IPR001636"
/db_xref="InterPro:IPR018236"
/db_xref="InterPro:IPR028923"
/db_xref="UniProtKB/Swiss-Prot:P9WHN1"
/inference="protein motif:PROSITE:PS01058"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43527.1"
/translation="MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDS
TIPDKGRVLTAMSAFFFGLVDAPNHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVA
RGYLTGSGLLDYQATGKVCGIALPPGLVEASRFATPLFTPATKAALGDHDENISFDRV
VEMVGALRANQLRDRTLQTYVQAADHALTRGIIIADTKFEFGIDRHGNLLLADEIFTP
DSSRYWPADDYRAGVVQTSFDKQFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRAR
YINAYERISELKFDDWIGPGA"
gene 874233..874943
/gene="ptrBa"
/gene_synonym="ptrBb"
/locus_tag="Rv0781"
CDS 874233..874943
/codon_start=1
/transl_table=11
/gene="ptrBa"
/gene_synonym="ptrBb"
/locus_tag="Rv0781"
/product="Probable protease II PtrBa [first part]
(oligopeptidase B)"
/note="Rv0781, (MTCY369.25), len: 236 aa. Probable
ptrBa,first part of protease II, equivalent to N-terminus
of NP_302455.1|NC_002677 protease II from Mycobacterium
leprae (724 aa). Also highly similar to N-termini of many
proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II
from Escherichia coli strains K12 and HB101 (707 aa),
FASTA scores: opt: 204, E(): 7.4e-07, (29.6% identity in
230 aa overlap); etc. ORFs Rv0782 and Rv0781 appear to be
a frameshifted homologues of protease II, but we can find
no error in the cosmid sequence to account for this.
Belongs to peptidase family S9A; also known as the prolyl
oligopeptidase family. Note that previously known as
ptrBb. Conserved in M. tuberculosis, M. leprae, M. bovis
and M. avium paratuberculosis; predicted to be essential
for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0781"
/db_xref="EnsemblGenomes-Tr:CCP43528"
/db_xref="GOA:P71835"
/db_xref="InterPro:IPR023302"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P71835"
/protein_id="CCP43528.1"
/translation="MMHRTALPSPPVAKRVQTRREHHGDVFVDPYEWLRDKDSPEVIA
YLEAENDYTERTTAHLEPLRQKIFHEIKARTKETDLSVPTRRGNWWYYARTFEGKQYG
VHCRCPVTDPDDWNPPEFDERTEIPGEQLLLDENVEADGHDFFALGAASVSLDDNLLA
YSVDVVGDERYTLRFKDLRTGEQYPDEIAGIGAGVTWAADNHCLLHHRGRGLASGHSV
AIPTRVRRIVGAGLPRSR"
gene 874732..876390
/gene="ptrBb"
/gene_synonym="ptrBa"
/locus_tag="Rv0782"
CDS 874732..876390
/codon_start=1
/transl_table=11
/gene="ptrBb"
/gene_synonym="ptrBa"
/locus_tag="Rv0782"
/product="Probable protease II PtrBb [second part]
(oligopeptidase B)"
/note="Rv0782, (MTCY369.26), len: 552 aa. Probable
ptrBb,second part of protease II, equivalent to C-terminus
of NP_302455.1|NC_002677 protease II from Mycobacterium
leprae (724 aa). Also highly similar to N-termini of many
proteases II e.g. P24555|PTRB_ECOLI|TLP|B1845 protease II
from Escherichia coli strains K12 and HB101 (707 aa),
FASTA scores: opt: 1251, E(): 0, (42.7% identity in 489 aa
overlap); etc. ORFs Rv0782 and Rv0781 appear to be a
frameshifted homologues of protease II, but we can find no
error in the cosmid sequence to account for this. Belongs
to peptidase family S9A; also known as the prolyl
oligopeptidase family. Note that previously known as
ptrBa. Conserved in M. tuberculosis, M. leprae, M. bovis
and M. avium paratuberculosis; predicted to be essential
for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0782"
/db_xref="EnsemblGenomes-Tr:CCP43529"
/db_xref="GOA:P71834"
/db_xref="InterPro:IPR001375"
/db_xref="InterPro:IPR002470"
/db_xref="InterPro:IPR023302"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P71834"
/protein_id="CCP43529.1"
/translation="MTNDIPCGSRIYAPENSTRTRSPGSERESPGQLTTTVYYTTVDA
AWRPDTVWRYRLGSGESSERVYHEADDRFWLAVGRTRSNAYLLIAAGSSITSEVRYAH
AADPTAQFSVVLPRRDGVEYSVEHAVIAGQDRFLILHNDGAVNFTLVEAPVEDPARQR
TLIAHRDDVRLDAVDALAGHLVVSYRREALPRVQLWPIGPDGNYGEPEEISFDSELMS
AGLGPNPNWDSPKLRVGAGSFVTPVRIYDIDLVTGERTLLKEQPVLGGYRREDYVERR
DWAYGDDGTRIPVSIVHRADIEFPAPALIYGYGAYEICEDPRFSIARLSLLDRGMVFV
VAHVRGGGEMGRLWYENGKLLDKKNTFTDFIAVARHLVDTGLTSQQQLVALGGSAGGL
LMGAVANMAPDLFAGILAQVPFVDPLTTILDPSLPLTVTEWDEWGNPLNDSDVYAYVK
SYSPYENVTAQKYPAILAMTSLNDTRVYYVEPAKWVAALRHAKTDGNSVLLKTQMHAG
HGGISGRYERWKETAFQYGWLLATADSDRYGGGQGNDLDGAAPA"
gene complement(876818..878440)
/gene="emrB"
/locus_tag="Rv0783c"
CDS complement(876818..878440)
/codon_start=1
/transl_table=11
/gene="emrB"
/locus_tag="Rv0783c"
/product="Possible multidrug resistance integral membrane
efflux protein EmrB"
/note="Rv0783c, (MTCY369.27c), len: 540 aa. Possible
emrB,integral membrane drug efflux protein, member of
major facilitator superfamily (MFS), equivalent to
AAL16083.1|AF421382_1|AF421382 EmrB efflux protein from
Mycobacterium avium (538 aa). Also similar to other
membrane proteins e.g. CAB61606.1|AL133210 putative export
protein from Streptomyces coelicolor (496 aa);
NP_108371.1|NC_002678 efflux pump protein FarB from
Mesorhizobium loti (511 aa); P44927|EMRB_HAEINHI0897|
multidrug resistance protein b homologue from Haemophilus
influenzae (510 aa), FASTA scores: opt: 706, E():
1.3e-36,(30.4% identity in 408 aa overlap); etc. Also
similar to Rv2333c|MTCY3G12.01 from Mycobacterium
tuberculosis (537 aa), FASTA score: (28.2% identity in 408
aa overlap); and Rv1410c|MTCY21B4.27c from Mycobacterium
tuberculosis (518 aa), FASTA score: (26.8% identity in 496
aa overlap). Belongs to the major facilitator family; also
known as the drug resistance translocase family."
/db_xref="EnsemblGenomes-Gn:Rv0783c"
/db_xref="EnsemblGenomes-Tr:CCP43530"
/db_xref="GOA:P9WG89"
/db_xref="InterPro:IPR001411"
/db_xref="InterPro:IPR004638"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WG89"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43530.1"
/translation="MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDRLDVGLLRT
AGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGWAA
DRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREA
GPKRLGRVMAVVGIPMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVF
PRDRPAASENFDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAF
VAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQ
SGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFGVARQADYLP
ILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQIARGSTLISVNQQVGGSIGTALMSVL
LTYQFNHSEIIATAKKVALTPESGAGRGAAVDPSSLPRQTNFAAQLLHDLSHAYAVVF
VIATALVVSTLIPAAFLPKQQASHRRAPLLSA"
gene 878638..879324
/locus_tag="Rv0784"
CDS 878638..879324
/codon_start=1
/transl_table=11
/locus_tag="Rv0784"
/product="Conserved hypothetical protein"
/note="Rv0784, (MTC369.28), len: 228 aa. Conserved
hypothetical protein, with some similarity to
MLCB5_20|O05752 hypothetical protein from Mycobacterium
leprae (193 aa), FASTA scores: opt: 141, E():
0.0022,(36.0% identity in 114 aa overlap). Also similar to
N-terminus of NP_253002.1|NC_002516 conserved hypothetical
protein from Pseudomonas aeruginosa (253 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0784"
/db_xref="EnsemblGenomes-Tr:CCP43531"
/db_xref="GOA:P71837"
/db_xref="InterPro:IPR011330"
/db_xref="InterPro:IPR018763"
/db_xref="UniProtKB/TrEMBL:P71837"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43531.1"
/translation="MSVSGIGESTLADVDAFCAEMDARSVPVSLLVAPRMRDDYRLDR
DPRTVDWLTGRRAAGDALVLHGYDEAATKRRRGEFAMLRAHEANLRLMAADRVLEHLG
LRTRLFAAPGWLVSPGVRTALPANGFRLLADLHGITDLVRLTTVRARVLGIGEGFLAE
PWWCRMVVMSAERIARRGGVVRIAVAARHLRKSGPLQAMLDAVDLAMLQGCTPMVYRW
RADAAVLDAA"
gene 879340..881040
/locus_tag="Rv0785"
CDS 879340..881040
/codon_start=1
/transl_table=11
/locus_tag="Rv0785"
/product="Conserved protein"
/note="Rv0785, (MTCY369.29), len: 566 aa. Conserved
protein, highly similar to other conserved hypothetical
proteins e.g. NP_105777.1| NC_002678 hypothetical protein
from Mesorhizobium loti (552 aa);
SC5F8.14|CAB93742.1|AL357613 conserved hypothetical
protein from Streptomyces coelicolor (557 aa);
AE001863|AE001863_31 from Deinococcus radiodurans (554
aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in
550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd
protein (470 aa),FASTA scores: opt: 169, E(): 0.0014,
(23.8% identity in 542 aa overlap); etc. Also similar to
Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487
aa), FASTA score: (26.7% identity in 587 aa overlap). And
shows similarity with other dehydrogenases."
/db_xref="EnsemblGenomes-Gn:Rv0785"
/db_xref="EnsemblGenomes-Tr:CCP43532"
/db_xref="GOA:P71838"
/db_xref="InterPro:IPR003953"
/db_xref="InterPro:IPR014614"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P71838"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43532.1"
/translation="MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRG
LRVLILDQENRANVGGQAFWSFGGLFLVNSPEQRRLGIRDSHELALQDWLGTAAFDRP
EDYWPEQWAHAYVDFAAGEKRSWLRARGLKIFPLVGWAERGGYDAQGHGNSVPRFHIT
WGTGPALVDIFVRQLRDRPTVRFAHRHQVDKLIVEGNAVTGVRGTVLEPSDEPRGAPS
SRKSVGKFEFRASAVIVASGGIGGNHELVRKNWPRRMGRIPKQLLSGVPAHVDGRMIG
IAQKAGAAVINPDRMWHYTEGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFP
GFDTLGTLEYITKSGHDYTWFVLNAKIIEKEFALSGQEQNPDLTGRRLGQLLRSRAHA
GPPGPVQAFIDRGVDCVHANSLRELVAAMNELPDVVPLDYETVAAAVTARDREVVNKY
SKDGQITAIRAARRYRGDRFGRVVAPHRLTDPKAGPLIAVKLHILTRKTLGGIETDLD
ARVLKADGTPLAGLYAAGEVAGFGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR
"
gene complement(881075..881464)
/locus_tag="Rv0786c"
CDS complement(881075..881464)
/codon_start=1
/transl_table=11
/locus_tag="Rv0786c"
/product="Conserved protein"
/note="Rv0786c, (MTCY369.30c), len: 129 aa. Conserved
protein, similar to three other hypothetical proteins from
Streptomyces coelicolor e.g. SC7H1.08c|T35703 hypothetical
protein (202 aa), FASTA scores: opt: 241, E():
5.1e-10,(41.0% identity in 105 aa overlap);
SC3A7.08|T29426 (211 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0786c"
/db_xref="EnsemblGenomes-Tr:CCP43533"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:P71839"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43533.1"
/translation="MHVGDELPLAELTVRAVGGCHAVIHPEIPVIENISYLVGDSKHR
ARLMHPGDALFVPGEQVDVLATPAAAPWMKISEAVDYLRAVAPARAVPIHQAIVAPDA
RGIYYGRLTEMTTTDFQVLPEESAVTF"
gene 881459..882418
/locus_tag="Rv0787"
CDS 881459..882418
/codon_start=1
/transl_table=11
/locus_tag="Rv0787"
/product="Unknown protein"
/note="Rv0787, (MTCY369.31), len: 319 aa. Unknown
protein,equivalent to AAK45053.1 from Mycobacterium
tuberculosis strain CDC1551 (242 aa) but longer 77 aa."
/db_xref="EnsemblGenomes-Gn:Rv0787"
/db_xref="EnsemblGenomes-Tr:CCP43534"
/db_xref="GOA:P71840"
/db_xref="UniProtKB/TrEMBL:P71840"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43534.1"
/translation="MHRPPWLAQLRRRLRIGVQLGSRVVLEQGRQPRDVYVIGVLVGD
QDRGQTGDSLEAVRESTGIEEQAGLTELSEEAGMAEMRELHVYDCALMGAFPMRLILA
TMLVAGRLLATLMAAPSAQAEPETCPPICDQIPATAWISTHAVPLNSQYRWPAMAGAA
VAVTRATPRFGFEQVCATPAFPHDSRDWAVAGRVTVVHPDGQWQLQAQVLHWRGDTAR
GGQIAASVFGTAVAALRACQLGAPLQSPSVTDDEPTRMAAVISGPVIMYTYLVAHVSS
STISELTLWSSGPPQVPWPTVADSAVLDALTAPLCEAYIGSCP"
gene 882524..882763
/locus_tag="Rv0787A"
CDS 882524..882763
/codon_start=1
/transl_table=11
/locus_tag="Rv0787A"
/product="Conserved protein"
/note="Rv0787A, len: 79 aa. Conserved protein, equivalent
to MLCB5.24 hypothetical protein from Mycobacterium leprae
(79 aa), FASTA scores: opt: 434, (84.8% identity in 79 aa
overlap). Also similar to P12049|YEXA_BACSU hypothetical
9.7 kDa protein from Bacillus subtilis (84 aa), FASTA
scores: opt: 172, E(): 4e-06, (44.4% identity in 72 aa
overlap). Belongs to the UPF0062 family."
/db_xref="EnsemblGenomes-Gn:Rv0787A"
/db_xref="EnsemblGenomes-Tr:CCP43535"
/db_xref="GOA:I6Y8S6"
/db_xref="InterPro:IPR003850"
/db_xref="InterPro:IPR036604"
/db_xref="UniProtKB/TrEMBL:I6Y8S6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43535.1"
/translation="MARVVVHVMPKAEILDPQGQAIVGALGRLGHLGISDVRQGKRFE
LEVDDTVDDTTLAEIAESLLANTVIEDWTISRDPQ"
gene 882760..883434
/gene="purQ"
/locus_tag="Rv0788"
CDS 882760..883434
/codon_start=1
/transl_table=11
/gene="purQ"
/locus_tag="Rv0788"
/product="Probable phosphoribosylformylglycinamidine
synthase I PURG (FGAM synthase I)"
/note="Rv0788, (MTCY369.32), len: 224 aa. Probable
purQ,phosphoribosylformylglycinamidine synthase I,
equivalent to MLCB5_24|Z95151|O05756|PURQ
phosphoribosylformylglycinamidine synthase I from
Mycobacterium leprae (224 aa), FASTA scores: opt:
1341,E(): 0, (88.7% identity in 222 aa overlap). Also
highly similar to others e.g. P12041|PURQ_BACSU
phosphoribosylformylglycinamidine synthase I from Bacillus
subtilis (227 aa), FASTA scores: opt: 691, E():
8.6e-39,(47.7% identity in 214 aa overlap); etc. Contains
PS00442 Glutamine amidotransferases class-I active site.
Belongs to type-1 glutamine amidotransferases."
/db_xref="EnsemblGenomes-Gn:Rv0788"
/db_xref="EnsemblGenomes-Tr:CCP43536"
/db_xref="GOA:P9WHL5"
/db_xref="InterPro:IPR010075"
/db_xref="InterPro:IPR017926"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:P9WHL5"
/inference="protein motif:PROSITE:PS00442"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43536.1"
/translation="MTARIGVVTFPGTLDDVDAARAARQVGAEVVSLWHADADLKGVD
AVVVPGGFSYGDYLRAGAIARFAPVMDEVVAAADRGMPVLGICNGFQVLCEAGLLPGA
LTRNVGLHFICRDVWLRVASTSTAWTSRFEPDADLLVPLKSGEGRYVAPEKVLDELEG
EGRVVFRYHDNVNGSLRDIAGICSANGRVVGLMPHPEHAIEALTGPSDDGLGLFYSAL
DAVLTG"
gene complement(883451..884050)
/locus_tag="Rv0789c"
CDS complement(883451..884050)
/codon_start=1
/transl_table=11
/locus_tag="Rv0789c"
/product="Hypothetical protein"
/note="Rv0789c, (MTCY369.33c), len: 199 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0789c"
/db_xref="EnsemblGenomes-Tr:CCP43537"
/db_xref="UniProtKB/TrEMBL:I6Y4U0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43537.1"
/translation="MSRRAIHSGRAAPRRSGNSHLVLRNRVPSSKDSPRRRPHHEFMT
ESIGEPLSTNLIERYLRARGRRYFRGHHDAEFFFVANAHLRLHVHLEISPAYRDVFTI
RVSPAYFFPATDHTRLAEIVNAWNLQNHEVTAIVHGSSDPHRIGVAAERSLIRDRIRF
DDFATFVDNAVSAATELFGQLTAAGLPPTATPPLLRDAG"
gene complement(884072..884800)
/locus_tag="Rv0790c"
CDS complement(884072..884800)
/codon_start=1
/transl_table=11
/locus_tag="Rv0790c"
/product="Hypothetical protein"
/note="Rv0790c, (MTCY369.34c), len: 242 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0790c"
/db_xref="EnsemblGenomes-Tr:CCP43538"
/db_xref="InterPro:IPR002931"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/TrEMBL:I6XWA9"
/protein_id="CCP43538.1"
/translation="MTLANNGTGMDHFLTPTEYLDAGHPLVRTTAATLIRDAVSDTER
VRRIYYYVRDVPYDVLASFRYLAQGHHRASDVIGHGVAFCMGKASSFVALCRAAGVPA
RIAFQTIDAPDKEFLSPQVRALWGGRTGRPFPWHSLGEAYLGRRWVKLDATIDAPTAA
RLGKPYRQEFDGATPIPTVEGTILRENGSYADYPSAVAQWYERIAQSVLKALQSTEVH
ALVAADEELWTGPPVELADATHRL"
gene complement(884797..885840)
/locus_tag="Rv0791c"
CDS complement(884797..885840)
/codon_start=1
/transl_table=11
/locus_tag="Rv0791c"
/product="Conserved protein"
/note="Rv0791c, (MTV042.01c, MTCY369.35c), len: 347 aa.
Conserved protein, similar (except in N-terminus) to
others e.g. CAC44585.1|AL596162 conserved hypothetical
protein from Streptomyces coelicolor (307 aa);
NP_252643.1|NC_002516 hypothetical protein from
Pseudomonas aeruginosa (364 aa); etc. Also some similarity
with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606
putative F420-dependent dehydrogenase from Rhodococcus
erythropolis (295 aa); etc. And also similar in part to
other proteins from Mycobacterium tuberculosis e.g.
Rv1855c|MTCY359.18|Z83859 (307 aa), FASTA scores: opt:
366,E(): 4e-16, (35.0% identity in 226 aa overlap);
Rv3079c|MTCY22D7.02|Z83866 conserved hypothetical protein
(275 aa), FASTA scores: opt: 342, E(): 1.2e-14, (31.6%
identity in 234 aa overlap); Rv0044c possible
oxidoreductase (264 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0791c"
/db_xref="EnsemblGenomes-Tr:CCP43539"
/db_xref="GOA:I6X9T8"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019921"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:I6X9T8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43539.1"
/translation="MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEYGFDSVW
LCDHFLTISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLPLLECWTALAALSRD
TTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQGRLDLGLGAGWFRRESQAYGIPFPP
VGDRVSALAESLQVIKAVWTEPNPTYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDR
VQRIAAKHAQGLNVRWWSPQQVTQRRGFLTQASEAAGRDPDTLRLSVTLLLAPTQSGE
EEVRIREEFASIPEPGLIVGTPDRCVERIREYQDRGVGHFLFTIPHVVKSDYLHIIGS
DIIPRVKTEVTIP"
gene complement(885837..886646)
/locus_tag="Rv0792c"
CDS complement(885837..886646)
/codon_start=1
/transl_table=11
/locus_tag="Rv0792c"
/product="Probable transcriptional regulatory protein
(probably GntR-family)"
/note="Rv0792c, (MTV042.02c), len: 269 aa. Probable
transcriptional regulator, GntR-family, similar to many
others of GntR family e.g. BSUB0018_189|Z99121 from
Bacillus subtilis (243 aa), FASTA scores: opt: 367, E():
1.5e-17, (32.1% identity in 246 aa overlap);
P31453|YIDP_ECOLI from Escherichia coli (238 aa), FASTA
scores: opt: 236, E(): 8.8e-09, (26.4% identity in 235 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0792c"
/db_xref="EnsemblGenomes-Tr:CCP43540"
/db_xref="GOA:O86331"
/db_xref="InterPro:IPR000524"
/db_xref="InterPro:IPR011663"
/db_xref="InterPro:IPR028978"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O86331"
/protein_id="CCP43540.1"
/translation="MTSVKLDLDAADLRISRGSVPASTQLAEALKAQIIQQRLPRGGR
LPSERELIDRSGLSRVTVRAAVGMLQRQGWLVRRQGLGTFVADPVEQELSCGVRTITE
VLLSCGVTPQVDVLSHQTGPAPQRISETLGLVEVLCIRRRIRTGDQPLALVTAYLPPG
VGPAVEPLLSGSADTETTYAMWERRLGVRIAQATHEIHAAGASPDVADALGLAVGSPV
LVVDRTSYTNDGKPLEVVVFHHRPERYQFSVTLPRTLPGSGAGIIEKRDFA"
gene 886719..887024
/locus_tag="Rv0793"
CDS 886719..887024
/codon_start=1
/transl_table=11
/locus_tag="Rv0793"
/product="Possible monooxygenase"
/note="Rv0793, (MTV042.03), len: 101 aa. Possible
monooxygenase (See Lemieux et al., 2005). Similar to e.g.
NP_250888.1|NC_002516 hypothetical protein from
Pseudomonas aeruginosa (114 aa); AE 001908|AE001908_7
hypothetical protein from Deinococcus radiodurans (101
aa), FASTA scores: opt: 215, E(): 3.1e-09, (40.4% identity
in 99 aa overlap); NP_440966.1|NC_000911|D90908|PCC6803|D9
0908_2 unknown protein from Synechocystis sp. strain PCC
6803 (147 aa), FASTA scores: opt: 194, E(): 4.5e-08,
(31.1% identity in 90 aa overlap); etc. Also similar to
Rv2749|MTV002.14|AL0089|MTV002_15 conserved hypothetical
protein from Mycobacterium tuberculosis (104 aa), FASTA
scores: opt: 143, E(): 0.00026, (26.9% identity in 93 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0793"
/db_xref="EnsemblGenomes-Tr:CCP43541"
/db_xref="GOA:O86332"
/db_xref="InterPro:IPR007138"
/db_xref="InterPro:IPR011008"
/db_xref="PDB:1Y0H"
/db_xref="UniProtKB/Swiss-Prot:O86332"
/protein_id="CCP43541.1"
/translation="MTSPVAVIARFMPRPDARSALRALLDAMITPTRAEDGCRSYDLY
ESADGGELVLFERYRSRIALDEHRGSPHYLNYRAQVGELLTRPVAVTVLAPLDEASA"
gene complement(887137..888636)
/gene_synonym="lpdB"
/locus_tag="Rv0794c"
CDS complement(887137..888636)
/codon_start=1
/transl_table=11
/gene_synonym="lpdB"
/locus_tag="Rv0794c"
/product="Probable oxidoreductase"
/note="Rv0794c, (MTV042.04c), len: 499 aa. Probable
oxidoreductase, possibly dihydrolipoamide dehydrogenase or
mercuric reductase. Highly similar to CAB62675.1|AL133422
probable oxidoreductase from Streptomyces coelicolor (477
aa); and similar to various oxidoreductases e.g.
P08663|MERA_STAAU mercuric reductase (HG(II) reductase)
from Staphylococcus aureus (547 aa);
AAK70920.1|AC087551_19|AC087551 putative lipoamide
dehydrogenase from Oryza sativa (563 aa);
NP_437349.1|NC_003078 putative FAD-dependent pyridine
nucleotide-disulphide oxidoreductase, similar to mercuric
reductases protein from Sinorhizobium meliloti (473 aa);
Q04829|DLDH_HALVO dihydrolipoamide dehydrogenase from
Haloferax volcanii (475 aa); P08332|MERA_SHIFL mercuric
reductase (564 aa), FASTA scores: opt: 522, E():
3.7e-26,(31.7% identity in 467 aa overlap);
P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096
dihydrolipoamide dehydrogenase from Synechocystis sp.
strain PCC 6803 (474 aa), FASTA scores: opt: 602, E():
2.3e-31, (31.0% identity in 493 aa overlap); etc. Note
that previously known as lpdB."
/db_xref="EnsemblGenomes-Gn:Rv0794c"
/db_xref="EnsemblGenomes-Tr:CCP43542"
/db_xref="GOA:I6Y4U4"
/db_xref="InterPro:IPR001100"
/db_xref="InterPro:IPR004099"
/db_xref="InterPro:IPR016156"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:I6Y4U4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43542.1"
/translation="MTAAQQDQAPMATPGCREGETYDVVVLGAGPVGQNVADRARAGG
LRVAVVERELVGGECSYWACVPSKALLRPVIAISDARRVDGAREAVDGSINTAGVFGR
RNRYVAHWDDTGQADWVSGIGATLIRGDGRLDGPRRVVVTKSSGESVALTARHAVVIC
TGSRPALPDLPGITEARPWTNRQATDNSTVPDRLAIVGAGGVGVEMATAWQGLGASVT
LLARGSGLLPRMEPFVGELIGRGLADAGVDVRVGVSVRALGRPNPTGPVVLELDDGTE
LRVDEVLFATGRAPRTDDIGLETIGLTPGSWLDVDDTCRVRAVDDGWLYAAGDVNHRA
LLTHQGKYQARIAGTAIGARAAGRPLDTTSWGMHATTADHHAVPQAFFTDPEAAAVGL
TADQAAQAGHRIKAIDVEIGDVVMGAKLFADGYTGRARMVVDVDRGHLLGVTMVGPGA
AELLHSATVAVAGQVPIDRLWHAVPCFPTISELWLRLLESYRDSFYLLV"
repeat_region 889017..889020
/note="4 bp direct repeat: GAGG, at the right end of
IS6110"
mobile_element 889021..890375
/mobile_element_type="insertion sequence:IS6110-1"
/note="IS6110-1, len: 1355 nt. Insertion sequence IS6110."
repeat_region 889021..889048
/note="28 bp inverted repeat at the left end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene 889072..889398
/locus_tag="Rv0795"
CDS 889072..889398
/codon_start=1
/transl_table=11
/locus_tag="Rv0795"
/product="Putative transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv0795, (MTV042.05), len: 108 aa. Putative
transposase for IS6110 (fragment), identical to Q50686
insertion element IS6110 (108 aa), FASTA score: (100.0 %
identity in 108 aa overlap). The transposase described
here may be made by a frame shifting mechanism during
translation that fuses Rv0795 and Rv0796, the sequence
UUUUAAAG (directly upstream of Rv0796) maybe responsible
for such a frameshifting event (see McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv0795"
/db_xref="EnsemblGenomes-Tr:CCP43543"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43543.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <889347..890333
/locus_tag="Rv0796"
CDS <889347..890333
/codon_start=1
/transl_table=11
/locus_tag="Rv0796"
/product="Putative transposase for insertion sequence
element IS6110"
/note="Rv0796, (MTV042.06), len: 328 aa. Putative
transposase for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv0795 and Rv0796, the
sequence UUUUAAAG (directly upstream of Rv0796) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (+ 50
aa)."
/db_xref="EnsemblGenomes-Gn:Rv0796"
/db_xref="EnsemblGenomes-Tr:CCP43544"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43544.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(890348..890375)
/note="28 bp inverted repeat at the right end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC"
repeat_region 890376..890379
/note="4 bp direct repeat: GAGG, at the left end of
IS6110"
gene 890388..891482
/locus_tag="Rv0797"
CDS 890388..891482
/codon_start=1
/transl_table=11
/locus_tag="Rv0797"
/product="Putative transposase for insertion sequence
element IS1547"
/note="Rv0797, (MTCI249B.03c, MTV042.07), len: 364 aa.
Putative transposase for IS1547; almost identical to (but
20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium
tuberculosis (383 aa). Also similar to other transposases
e.g. MAIS1110A _1|Q48909 transposase from Mycobacterium
avium (464 aa), FASTA scores: opt: 226, E():
2.4e-08,(30.7% identity in 199 aa overlap). Also slight
similarity to Rv2014|MTCY39.03c from Mycobacterium
tuberculosis (222 aa), FASTA score: (24.8% identity in 141
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0797"
/db_xref="EnsemblGenomes-Tr:CCP43545"
/db_xref="GOA:O07182"
/db_xref="InterPro:IPR002525"
/db_xref="InterPro:IPR003346"
/db_xref="UniProtKB/TrEMBL:O07182"
/protein_id="CCP43545.1"
/translation="MVVVGTDAHKYSHTFVATDEVGRQLGEKTVKATTAGHATAIMWA
REQFGLELIWGIEDCRNMSARLERDLLAAGQQVVRVPTKLMAQTRKSARSRGKSDPID
ALAVARAVMRETDLPLATHDETSRELKLLTDRRDVLVAQRTSAINRLRWLVHELDPER
APAARSLDAAKHQQALRTWLDTQPGLVAELARAELTDIIRLTGEINTLAQRISARVHQ
VAPALLEIPGCAELTAAKIVGEAAGVTRFKSEAAFACHAAVAPIPVWSGNTAGQMRLS
RSGNRQLNAALHRIALTQIRMTDSRGQAYYQRLQDAGKTKRAALRCLKRRLARTVFQA
LRTVHQPSSEHTQPAAACHRSYCSRSCLSG"
mobile_element 890388..891479
/mobile_element_type="insertion sequence:IS1547-1"
/locus_tag="Rv0797"
/note="IS1547-1, len: 1092 nt. Insertion sequence IS1547."
gene complement(891472..892269)
/gene="cfp29"
/locus_tag="Rv0798c"
CDS complement(891472..892269)
/codon_start=1
/transl_table=11
/gene="cfp29"
/locus_tag="Rv0798c"
/product="29 KDa antigen CFP29"
/note="Rv0798c, (MTCI429B.02), len: 265 aa. Cfp29, 29 kDa
antigen (see citations below). Highly similar to
Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from
Brevibacterium linens (266 aa), FASTA scores: (58.5%
identity in 265 aa overlap). Also shows similarity with
NP_228594.1|NC_000853 bacteriocin from Thermotoga maritima
(262 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0798c"
/db_xref="EnsemblGenomes-Tr:CCP43546"
/db_xref="GOA:I6WZG6"
/db_xref="InterPro:IPR007544"
/db_xref="UniProtKB/TrEMBL:I6WZG6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43546.1"
/translation="MNNLYRDLAPVTEAAWAEIELEAARTFKRHIAGRRVVDVSDPGG
PVTAAVSTGRLIDVKAPTNGVIAHLRASKPLVRLRVPFTLSRNEIDDVERGSKDSDWE
PVKEAAKKLAFVEDRTIFEGYSAASIEGIRSASSNPALTLPEDPREIPDVISQALSEL
RLAGVDGPYSVLLSADVYTKVSETSDHGYPIREHLNRLVDGDIIWAPAIDGAFVLTTR
GGDFDLQLGTDVAIGYASHDTDTVRLYLQETLTFLCYTAEASVALSH"
gene complement(892266..893273)
/locus_tag="Rv0799c"
CDS complement(892266..893273)
/codon_start=1
/transl_table=11
/locus_tag="Rv0799c"
/product="Conserved protein"
/note="Rv0799c, (MTCY07H7A.10, MTCI429B.01), len: 335 aa.
Conserved protein, similar to Q50021|U2266C from
Mycobacterium leprae (146 aa), FASTA scores: opt: 147,
E(): 0.0016, (33.3% identity in 117 aa overlap);
Q50020|U2266B from Mycobacterium leprae (27 aa), FASTA
scores: opt: 94,E(): 1.3, (56.5% identity in 23 aa
overlap). Also highly similar to others e.g.
CAC01593.1|AL391041 conserved hypothetical protein from
Streptomyces coelicolor (316 aa); AF088897|AF088897_9
hypothetical protein from Zymomonas mobilis (322 aa),
FASTA scores: opt: 1132, E(): 0, (56.1% identity in 303 aa
overlap); P76536|ECAE000330_8 hypothetical protein from
Escherichia coli strain K-12 (308 aa), FASTA scores: E():
2.2e-30, (37.4% identity in 297 aa overlap); etc. Also
similar to some tyrA proteins. Predicted to be an outer
membrane protein (See Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0799c"
/db_xref="EnsemblGenomes-Tr:CCP43547"
/db_xref="GOA:I6Y4U9"
/db_xref="InterPro:IPR006314"
/db_xref="InterPro:IPR011008"
/db_xref="UniProtKB/TrEMBL:I6Y4U9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43547.1"
/translation="MAVPAVSPQPILAPLTPAAIFLVATIGADGEATVHDALSKISGL
VRAIGFRDPTKHLSVVVSIGSDAWDRLFAGPRPTELHPFVELTGPRHTAPATPGDLLF
HIRAETMDVCFELAGRILKSMGDAVTVVDEVHGFRFFDNRDLLGFVDGTENPSGPIAI
KATTIGDEDRNFAGSCYVHVQKYVHDMASWESLSVTEQERVIGRTKLDDIELDDNAKP
ANSHVALNVITDDDGTERKIVRHNMPFGEVGKGEYGTYFIGYSRTPTVTEQMLRNMFL
GDPAGNTDRVLDFSTAVTGGLFFSPTIDFLDHPPPLPQAATPTLAAGSLSIGSLKGSP
R"
gene 893318..894619
/gene="pepC"
/locus_tag="Rv0800"
CDS 893318..894619
/codon_start=1
/transl_table=11
/gene="pepC"
/locus_tag="Rv0800"
/product="Probable aminopeptidase PepC"
/note="Rv0800, (MTCY07H7A.09c), len: 433 aa. Probable
pepC,aminopeptidase I, highly similar (but shorter 17 aa)
to Q50022|PEPX aminopeptidase from Mycobacterium leprae
(443 aa), FASTA scores: opt: 2237, E(): 0, (78.3% identity
in 433 aa overlap). Also highly similar to others from
Eukaryotes and bacteria, e.g. T36482 probable
aminopeptidase from Streptomyces coelicolor (432
aa),P14904|AMPL_YEAST vacuolar aminopeptidase I precursor
from Saccharomyces cerevisiae (514 aa), FASTA scores: opt:
425,E(): 4.8e-21, (31.0% identity in 445 aa overlap); etc.
Also similar to hypothetical proteins e.g.
P38821|YHR3_YEAST hypothetical 54.2 kDa protein from
Saccharomyces cerevisiae (490 aa), FASTA scores: opt: 429,
E(): 2.5e-21, (34.8% identity in 443 aa overlap); etc.
Conserved in M. tuberculosis, M. leprae, M. bovis and M.
avium paratuberculosis; predicted to be essential for in
vivo survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0800"
/db_xref="EnsemblGenomes-Tr:CCP43548"
/db_xref="GOA:P9WHT1"
/db_xref="InterPro:IPR001948"
/db_xref="InterPro:IPR022984"
/db_xref="InterPro:IPR023358"
/db_xref="UniProtKB/Swiss-Prot:P9WHT1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43548.1"
/translation="MAATAHGLCEFIDASPSPFHVCATVAGRLLGAGYRELREADRWP
DKPGRYFTVRAGSLVAWNAEQSGHTQVPFRIVGAHTDSPNLRVKQHPDRLVAGWHVVA
LQPYGGVWLHSWLDRDLGISGRLSVRDGTGVSHRLVLIDDPILRVPQLAIHLAEDRKS
LTLDPQRHINAVWGVGERVESFVGYVAQRAGVAAADVLAADLMTHDLTPSALIGASVN
GTASLLSAPRLDNQASCYAGMEALLAVDVDSASSGFVPVLAIFDHEEVGSASGHGAQS
DLLSSVLERIVLAAGGTREDFLRRLTTSMLASADMAHATHPNYPDRHEPSHPIEVNAG
PVLKVHPNLRYATDGRTAAAFALACQRAGVPMQRYEHRADLPCGSTIGPLAAARTGIP
TVDVGAAQLAMHSARELMGAHDVAAYSAALQAFLSAELSEA"
gene 894631..894978
/locus_tag="Rv0801"
CDS 894631..894978
/codon_start=1
/transl_table=11
/locus_tag="Rv0801"
/product="Conserved protein"
/note="Rv0801, (MTCY07H7A.08c), len: 115 aa. Conserved
protein, similar to many hypothetical proteins from
Streptomyces sp. e.g. SCD840A.20|AB81865.1|AL161691
hypothetical protein from Streptomyces coelicolor (145
aa); AF072709|AF072709_8 from Streptomyces lividans (131
aa),FASTA scores: opt: 120, E(): 0.2, (26.3% identity in
118 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0801"
/db_xref="EnsemblGenomes-Tr:CCP43549"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="InterPro:IPR041581"
/db_xref="UniProtKB/TrEMBL:O06633"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43549.1"
/translation="MALKVEMVTFDCSDPAKLAGWWAEQFDGTTRELLPGEFVVVART
DGPRLGFQKVPDPAPGKNRVHLDFTTKDLDAEVLRLVAAGASEVGRHQVGESFRWVVL
ADPEGNAFCVAGQ"
gene complement(894972..895628)
/locus_tag="Rv0802c"
CDS complement(894972..895628)
/codon_start=1
/transl_table=11
/locus_tag="Rv0802c"
/product="Possible succinyltransferase in the GCN5-related
N-acetyltransferase family"
/note="Rv0802c, (MTCY07H7A.07c), len: 218 aa. Possible
succinyltransferase in the GNAT (Gcn5-related
N-acetyltransferase) family (See Vetting et al., 2008).
Shows partial similarity with many acetyltransferases and
hypothetical proteins e.g. P96579|BSUB0003_68 probable
acetyltransferase from Bacillus subtilis (183 aa), FASTA
scores: E(): 0.0044, (26.4% identity in 110 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0802c"
/db_xref="EnsemblGenomes-Tr:CCP43550"
/db_xref="GOA:P9WQG7"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="PDB:2VZY"
/db_xref="PDB:2VZZ"
/db_xref="UniProtKB/Swiss-Prot:P9WQG7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43550.1"
/translation="MSRHWPLFDLRITTPRLQLQLPTEELCDQLIDTILEGVHDPDRM
PFSVPWTRASREDLPFNTLSHLWQQLAGFKRDDWSLPLAVLVDGRAVGVQALSSKDFP
ITRQVDSGSWLGLRYQGHGYGTEMRAAVLYFAFAELEAQVATSRSFVDNPASIAVSRR
NGYRDNGLDRVAREGAMAEALLFRLTRDDWQRHRTVEVRVDGFDRCRPLFGPLEPPRY
"
gene 895820..898084
/gene="purL"
/locus_tag="Rv0803"
CDS 895820..898084
/codon_start=1
/transl_table=11
/gene="purL"
/locus_tag="Rv0803"
/product="Phosphoribosylformylglycinamidine synthase II
PurL (FGAM synthase II)"
/note="Rv0803, (MTCY07H7A.06c), len: 754 aa.
PurL,phosphoribosylformylglycinamidine synthase II (see
citations below), equivalent to NP_302451.1|NC_002677
phosphoribosylformylglycinamidine synthase II from
Mycobacterium leprae (754 aa). Also highly similar to
others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor
(752 aa); P12042|PURL_BACSU from Bacillus subtilis (742
aa), FASTA score: (44.7% identity in 716 aa); etc. Start
was chosen by similarity. Belongs to the FGAMS family."
/db_xref="EnsemblGenomes-Gn:Rv0803"
/db_xref="EnsemblGenomes-Tr:CCP43551"
/db_xref="GOA:P9WHL7"
/db_xref="InterPro:IPR010074"
/db_xref="InterPro:IPR010918"
/db_xref="InterPro:IPR016188"
/db_xref="InterPro:IPR036676"
/db_xref="InterPro:IPR036921"
/db_xref="InterPro:IPR041609"
/db_xref="UniProtKB/Swiss-Prot:P9WHL7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43551.1"
/translation="MLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTEL
AMYSVMWSEHCSYKSSKVHLRYFGETTSDEMRAAMLAGIGENAGVVDIGDGWAVTFKV
ESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVV
RGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIIL
FGARTGLDGIGGVSVLASDTFDAEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVI
GIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQERMCAVVS
PKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGPVYQRPV
ARPDTQDALNADRSAKLSRPVTGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTV
LAEHADGGMLRIDESTGRGIAVSTDASGRYTLLDPYAGAQLALAEAYRNVAVTGATPV
AVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTGSAAILPTP
VVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTADHLGGLPPVVD
LAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPEGADPFV
LLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGVVDQGSDAVEVQGLFAVSLAE
LRATSEAVLPRYFG"
gene 898081..898710
/locus_tag="Rv0804"
CDS 898081..898710
/codon_start=1
/transl_table=11
/locus_tag="Rv0804"
/product="Conserved hypothetical protein"
/note="Rv0804, (MTCY07H7A.05c), len: 209 aa. Conserved
hypothetical protein, showing similarity with C-terminus
of Rv1863c|MTCY359.10 conserved hypothetical protein from
Mycobacterium tuberculosis (256 aa), FASTA scores: opt:
199, E(): 1.2e-05, (33.2% identity in 220 aa overlap); and
Rv0658c. Contains PS01151 Fimbrial biogenesis outer
membrane usher protein signature."
/db_xref="EnsemblGenomes-Gn:Rv0804"
/db_xref="EnsemblGenomes-Tr:CCP43552"
/db_xref="GOA:I6Y4V2"
/db_xref="InterPro:IPR003675"
/db_xref="InterPro:IPR015837"
/db_xref="UniProtKB/TrEMBL:I6Y4V2"
/inference="protein motif:PROSITE:PS01151"
/protein_id="CCP43552.1"
/translation="MSRLRALSLAAGLVGWSLVSPRLPAPWRIPLQAGLGSVLVLVTR
ATMGLWPPRLWAGLRLGWAAGAAAATAIAATTPVPMVRLSMSARELPASVPVWLVWHI
PGGTVWAEEAAFRGALATIGARAFGRSGGRILQAGAFGLSHIADARATGEPLVLTVLA
TGIAGWMFGWLADRSGSLAAPLLTHLAINEAGAVAAVLVQRRSGISTRL"
gene 898831..899787
/locus_tag="Rv0805"
CDS 898831..899787
/codon_start=1
/transl_table=11
/locus_tag="Rv0805"
/product="Class III cyclic nucleotide phosphodiesterase
(cNMP PDE)"
/note="Rv0805, (MTCY07H7A.04c), len: 318 aa. Cyclic
nucleotide phosphodiesterase (cNMP PDE) (See Shenoy et
al.,2005), member of binuclear metallophosphoesterase
superfamily, equivalent to Q50024 from Mycobacterium
leprae (317 aa), FASTA scores: opt: 1713, E(): 0, (82.5%
identity in 315 aa overlap). Also shows similarity with
hypothetical proteins and icc proteins e.g.
SC9B1.22c|T35867 hypothetical protein from Streptomyces
coelicolor (305 aa); P36650|ICC_ECOLI icc protein from
Escherichia coli (275 aa), FASTA scores: opt: 310, E():
8.9e-14, (31.3% identity in 214 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0805"
/db_xref="EnsemblGenomes-Tr:CCP43553"
/db_xref="GOA:P9WP65"
/db_xref="InterPro:IPR004843"
/db_xref="InterPro:IPR026575"
/db_xref="InterPro:IPR029052"
/db_xref="PDB:2HY1"
/db_xref="PDB:2HYO"
/db_xref="PDB:2HYP"
/db_xref="PDB:3IB7"
/db_xref="PDB:3IB8"
/db_xref="UniProtKB/Swiss-Prot:P9WP65"
/protein_id="CCP43553.1"
/translation="MHRLRAAEHPRPDYVLLHISDTHLIGGDRRLYGAVDADDRLGEL
LEQLNQSGLRPDAIVFTGDLADKGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRA
ELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPA
PDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVG
IPVSVASATCYTQDLTVAAGGTRGRDGAQGCNLVHVYPDTVVHSVIPLGGGETVGTFV
SPGQARRKIAESGIFIEPSRRDSLFKHPPMVLTSSAPRSPVD"
gene complement(899732..901330)
/gene="cpsY"
/locus_tag="Rv0806c"
CDS complement(899732..901330)
/codon_start=1
/transl_table=11
/gene="cpsY"
/locus_tag="Rv0806c"
/product="Possible UDP-glucose-4-epimerase CpsY
(galactowaldenase) (UDP-galactose-4-epimerase) (uridine
diphosphate galactose-4-epimerase) (uridine
diphospho-galactose-4-epimerase)"
/note="Rv0806c, (MTCY07H7A.03), len: 532 aa. Possible
cpsY,UDP-glucose-4-epimerase, equivalent to Q50025|CPSY
probable UDP-glucose-4-epimerase from Mycobacterium leprae
(542 aa),FASTA scores: opt: 2964, E(): 0, (82.3% identity
in 530 aa overlap). Also similar to
AAC38286.1|AF019760|SACB CpsY homolog (involved in
meningococcal capsule biosynthesis) from Neisseria
meningitidis serogroup a (545 aa); Q51151 capsule gene
complex UPD-glucose-4-epimerase (gale) from Neisseria
meningitidis (373 aa), FASTA scores: opt: 496,E():
9.5e-27, (29.3% identity in 358 aa overlap); C-terminus of
CAB75373.1|AL139298 putative transferase from Streptomyces
coelicolor (942 aa); and many hypothetical proteins from
Streptomyces coelicolor. Seems to belong to the sugar
epimerase family."
/db_xref="EnsemblGenomes-Gn:Rv0806c"
/db_xref="EnsemblGenomes-Tr:CCP43554"
/db_xref="GOA:P9WGD1"
/db_xref="InterPro:IPR021520"
/db_xref="InterPro:IPR031356"
/db_xref="InterPro:IPR031357"
/db_xref="InterPro:IPR031358"
/db_xref="UniProtKB/Swiss-Prot:P9WGD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43554.1"
/translation="MPKISSRDGGRPAQRTVNPIIVTRRGKIARLESGLTPQEAQIED
LVFLRKVLNRADIPYLLIRNHKNRPVLAINIELRAGLERALAAACATEPMYAKTIDEP
GLSPVLVATDGLSQLVDPRVVRLYRRRIAPGGFRYGPAFGVELQFWVYEETVIRCPVE
NSLSRKVLPRNEITPTNVKLYGYKWPTLDGMFAPHASDVVFDIDMVFSWVDGSDPEFR
ARRMAQMSQYVVGEGDDAEARIRQIDELKYALRSVNMFAPWIRRIFIATDSTPPPWLA
EHPKITIVRAEDHFSDRSALPTYNSHAVESQLHHIPGLSEHFLYSNDDMFFGRPLKAS
MFFSPGGVTRFIEAKTRIGLGANNPARSGFENAARVNRQLLFDRFGQVITRHLEHTAV
PLRKSVLIEMEREFPEEFARTAASPFRSDTDISVTNSFYHYYALMTGRAVPQEKAKVL
YVDTTSYAGLRLLPKLRKHRGYDFFCLNDGSFPEVPAAQRAERVVSFLERYFPIPAPW
EKIAADVSRRDFAVPRTSAPSEGA"
gene 901635..902024
/locus_tag="Rv0807"
CDS 901635..902024
/codon_start=1
/transl_table=11
/locus_tag="Rv0807"
/product="Conserved hypothetical protein"
/note="Rv0807, (MTCY07H7A.02c), len: 129 aa. Conserved
hypothetical protein, equivalent to O05761|MLCB5_31
hypothetical 14.0 kDa protein from Mycobacterium leprae
(131 aa), FASTA scores: E(): 0, (73.4% identity in 128 aa
overlap). Also highly similar to BAA89438.1|AB003158|ORF3
hypothetical protein from Corynebacterium ammoniagenes
(132 aa); and C-terminus of SCD25.20|CAB56364.1|AL118514
hypothetical protein from Streptomyces coelicolor (202
aa)."
/db_xref="EnsemblGenomes-Gn:Rv0807"
/db_xref="EnsemblGenomes-Tr:CCP43555"
/db_xref="InterPro:IPR041629"
/db_xref="UniProtKB/TrEMBL:I6Y8U3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43555.1"
/translation="MSARDRVDPAKTRQVVLALADWLRDETLPAPDTDVLAAAVRLTA
RTLAALAPGASVEVRIPPFAAVQCISGPRHTRGTPPNVVQTDPRTWLLVATGLSGVAQ
ARGSGALQLSGSRAGEIEAWLPLVDLG"
gene 902111..903694
/gene="purF"
/locus_tag="Rv0808"
CDS 902111..903694
/codon_start=1
/transl_table=11
/gene="purF"
/locus_tag="Rv0808"
/product="Amidophosphoribosyltransferase PurF (glutamine
phosphoribosylpyrophosphate amidotransferase) (ATASE)
(gpatase)"
/note="Rv0808, (MTCY07H7A.01c), len: 527 aa.
PurF,amidophosphoribosyltransferase, equivalent to
MLCB5_32|Q50028|PURF from Mycobacterium leprae (556
aa),FASTA scores: (91.3% identity in 518 aa overlap); and
CAB96578.1|AJ278609 phosphoribosyl pyrophosphate
amidotransferase from Mycobacterium smegmatis (511 aa)(see
citation below). Also highly similar to others e.g.
BAA89439.1|AB003158 amidophosphoribosyl transferase from
Corynebacterium ammoniagenes (490 aa); P00497|PUR1_BACSU
amidophosphoribosyltransferase precursor from Bacillus
subtilis (476 aa), FASTA scores: opt: 1412, E(): 0, (46.2%
identity in 470 aa overlap); etc. Contains PS00103
Purine/pyrimidine phosphoribosyl transferases signature.
Belongs to the purine/pyrimidine phosphoribosyltransferase
family."
/db_xref="EnsemblGenomes-Gn:Rv0808"
/db_xref="EnsemblGenomes-Tr:CCP43556"
/db_xref="GOA:P9WHQ7"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR005854"
/db_xref="InterPro:IPR017932"
/db_xref="InterPro:IPR029055"
/db_xref="InterPro:IPR029057"
/db_xref="InterPro:IPR035584"
/db_xref="UniProtKB/Swiss-Prot:P9WHQ7"
/inference="protein motif:PROSITE:PS00103"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43556.1"
/translation="MAVDSDYVTDRAAGSRQTVTGQQPEQDLNSPREECGVFGVWAPG
EDVAKLTYYGLYALQHRGQEAAGIAVADGSQVLVFKDLGLVSQVFDEQTLAAMQGHVA
IGHCRYSTTGDTTWENAQPVFRNTAAGTGVALGHNGNLVNAAALAARARDAGLIATRC
PAPATTDSDILGALLAHGAADSTLEQAALDLLPTVRGAFCLTFMDENTLYACRDPYGV
RPLSLGRLDRGWVVASETAALDIVGASFVRDIEPGELLAIDADGVRSTRFANPTPKGC
VFEYVYLARPDSTIAGRSVHAARVEIGRRLARECPVEADLVIGVPESGTPAAVGYAQE
SGVPYGQGLMKNAYVGRTFIQPSQTIRQLGIRLKLNPLKEVIRGKRLIVVDDSIVRGN
TQRALVRMLREAGAVELHVRIASPPVKWPCFYGIDFPSPAELIANAVENEDEMLEAVR
HAIGADTLGYISLRGMVAASEQPTSRLCTACFDGKYPIELPRETALGKNVIEHMLANA
ARGAALGELAADDEVPVGR"
gene 903725..904819
/gene="purM"
/locus_tag="Rv0809"
CDS 903725..904819
/codon_start=1
/transl_table=11
/gene="purM"
/locus_tag="Rv0809"
/product="Probable phosphoribosylformylglycinamidine
CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole
synthetase) (air synthase)"
/note="Rv0809, (MTV043.01), len: 364 aa. Probable
purM,5'-phosphoribosyl-5-aminoimidazole synthetase,
equivalent to NP_302446.1|NC_002677
5'-phosphoribosyl-5-aminoimidazole synthase from
Mycobacterium leprae (364 aa). Also highly similar to many
e.g. P12043|PUR5_BACSU phosphoribosylformylglycinamidine
CYCLO-ligase from Bacillus subtilis (346 aa), FASTA
scores: opt: 1023, E(): 0, (46.5% identity in 331 aa
overlap); U68765|STU68765_2 from Salmonella typhimurium
(345 aa), FASTA scores: opt: 1014, E():0, (47.6% identity
in 330 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0809"
/db_xref="EnsemblGenomes-Tr:CCP43557"
/db_xref="GOA:I6Y4V6"
/db_xref="InterPro:IPR004733"
/db_xref="InterPro:IPR010918"
/db_xref="InterPro:IPR016188"
/db_xref="InterPro:IPR036676"
/db_xref="InterPro:IPR036921"
/db_xref="UniProtKB/TrEMBL:I6Y4V6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43557.1"
/translation="MTDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKAT
RPEVRGGLGGFAGLFTLRGDYREPVLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVV
DDLVVCGAEPLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIE
PDHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMN
LAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHG
LIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVAPEDTTRALAVLTA
RHLDCWVLGTVCKGGKQGPRAKLVGQHPRF"
gene complement(904905..905087)
/locus_tag="Rv0810c"
CDS complement(904905..905087)
/codon_start=1
/transl_table=11
/locus_tag="Rv0810c"
/product="Conserved hypothetical protein"
/note="Rv0810c, (MTV043.02c), len: 60 aa. Conserved
hypothetical protein, with its N-terminus highly similar
to NP_302445.1|NC_002677 conserved hypothetical protein
from Mycobacterium leprae (62 aa); and AL118514|SCD25_24
hypothetical protein from Streptomyces coelicolor (84
aa),FASTA scores: opt: 180, E(): 5.7e-07, (51.8% identity
in 56 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0810c"
/db_xref="EnsemblGenomes-Tr:CCP43558"
/db_xref="InterPro:IPR021426"
/db_xref="UniProtKB/TrEMBL:I6XWB9"
/protein_id="CCP43558.1"
/translation="MGRGRAKAKQTKVARELKYSSPQTDFQRLQRELSGTGTDRLDGD
GPSDDDSWNDEDDWRR"
gene complement(905234..906340)
/locus_tag="Rv0811c"
CDS complement(905234..906340)
/codon_start=1
/transl_table=11
/locus_tag="Rv0811c"
/product="Conserved protein"
/note="Rv0811c, (MTV043.03c), len: 368 aa. Conserved
protein, equivalent to U2266F|U15182|MLU15182_13
hypothetical protein from Mycobacterium leprae (366
aa),FASTA scores: opt: 1870, E(): 0, (77.4% identity in
367 aa overlap). Also highly similar to
BAA89441.1|AB003158|ORF4 hypothetical protein from
Corynebacterium ammoniagenes (359 aa); and
CAB94085.1|AL358692 conserved hypothetical protein from
Streptomyces coelicolor (321 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0811c"
/db_xref="EnsemblGenomes-Tr:CCP43559"
/db_xref="GOA:I6X9V3"
/db_xref="InterPro:IPR006222"
/db_xref="InterPro:IPR017703"
/db_xref="InterPro:IPR027266"
/db_xref="InterPro:IPR028896"
/db_xref="UniProtKB/TrEMBL:I6X9V3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43559.1"
/translation="MAAVPAPDPGPDAGAIWHYGDPLGEQRAGQADAVLVDRSHRAVL
TLDGGDRQTWLHSISTQHVSDLPEGASTQNLSLDGQGRVEDHWIQTELGGTTYLDTEP
WRGEPLLAYLRKMVFWSMVTPRAADMAVLSLLGPRLAEERVLDALGLDVLPAEWLAVP
LAGGGIVRRMPDGLAGQIELDVVVKRGDRADWQRRLTQAGVRPAGIWAYEAHRVAHRV
PARRPRLGVDTDERTIPHEVGWIGGPGAGAVHLNKGCYRGQETVARVHNLGRPPRMLV
LLHLDESVQRPSTGDAVLAGGRTVGRLGTVVEHVELGPVALALLKRGLPGDTALVTGP
EAEVAAVIDVDSLPPADDVGAGRRAVERLRGGIR"
gene 906423..907292
/gene_synonym="pabC"
/locus_tag="Rv0812"
CDS 906423..907292
/codon_start=1
/transl_table=11
/gene_synonym="pabC"
/locus_tag="Rv0812"
/product="Probable amino acid aminotransferase"
/note="Rv0812, (MTV043.04), len: 289 aa. Probable amino
acid aminotransferase, similar to other amino acid
aminotransferases, generelly class-IV of
pyridoxal-phosphate-dependent aminotransferases, and
especially ILVE proteins and PABC proteins e.g.
B76065.1|AL157953 putative aminotransferase from
Streptomyces coelicolor (273 aa); NP_069766.1|NC_000917
branched-chain amino acid aminotransferase (ilvE) from
Archaeoglobus fulgidus (290 aa); P54692|DAAA_BACLI
D-alanine aminotransferase from Bacillus licheniformis
(283 aa); P28305|PABC_ECOLI|B1096
4-amino-4-deoxychorismate lyase (ADC lyase) From
Escherichia coli strain K12 (269 aa), FASTA scores: opt:
165, E(): 0.00064, (26.8% identity in 198 aa overlap);
etc. Note that previously known as pabC."
/db_xref="EnsemblGenomes-Gn:Rv0812"
/db_xref="EnsemblGenomes-Tr:CCP43560"
/db_xref="GOA:Q79FW0"
/db_xref="InterPro:IPR001544"
/db_xref="InterPro:IPR017824"
/db_xref="InterPro:IPR036038"
/db_xref="UniProtKB/TrEMBL:Q79FW0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43560.1"
/translation="MVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLV
EAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSA
PTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLIASAKTLSYAVNMAVL
RHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDGDQGGGNPCLLTPPPWYPILRGTTQ
QALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEV
FAELVDAAIVSDR"
gene complement(907338..908018)
/locus_tag="Rv0813c"
CDS complement(907338..908018)
/codon_start=1
/transl_table=11
/locus_tag="Rv0813c"
/product="Conserved protein"
/note="Rv0813c, (MTV043.05c), len: 226 aa. Conserved
protein, highly similar to U15182|MLU15182_16 hypothetical
protein from Mycobacterium leprae (242 aa), FASTA scores:
opt: 1191, E(): 0, (78.3% identity in 226 aa overlap); and
NP_302442.1|NC_002677 conserved hypothetical protein from
Mycobacterium leprae (228 aa). Also similar to
AB94083.1|AL358692|SCD66.16 hypothetical protein from
Streptomyces coelicolor (191 aa); and Rv2717c|MTCY05A6_37
hypothetical protein from Mycobacterium tuberculosis (164
aa), FASTA score: (30.4% identity in 171 aa overlap).
Possibly a new bacterial family of fatty acid-binding
protein-like proteins (See Shepard et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0813c"
/db_xref="EnsemblGenomes-Tr:CCP43561"
/db_xref="GOA:P9WFG9"
/db_xref="InterPro:IPR012674"
/db_xref="InterPro:IPR014878"
/db_xref="InterPro:IPR022939"
/db_xref="PDB:2FWV"
/db_xref="UniProtKB/Swiss-Prot:P9WFG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43561.1"
/translation="MSSGAGSDATGAGGVHAAGSGDRAVAAAVERAKATAARNIPAFD
DLPVPADTANLREGADLNNALLALLPLVGVWRGEGEGRGPDGDYRFGQQIVVSHDGGD
YLNWESRSWRLTATGDYQEPGLREAGFWRFVADPYDPSESQAIELLLAHSAGYVELFY
GRPRTQSSWELVTDALARSRSGVLVGGAKRLYGIVEGGDLAYVEERVDADGGLVPHLS
ARLSRFVG"
gene complement(908181..908483)
/gene="sseC2"
/locus_tag="Rv0814c"
CDS complement(908181..908483)
/codon_start=1
/transl_table=11
/gene="sseC2"
/locus_tag="Rv0814c"
/product="Conserved protein SseC2"
/note="Rv0814c, (MTV043.06c, O05794), len: 100 aa.
SseC2,conserved protein, highly similar to
AAA62972.1|U15182|MLU15182_17 hypothetical protein from
Mycobacterium leprae (143 aa), FASTA scores: opt: 545,
E(): 0, (84.0% identity in 100 aa overlap); and
NP_302441.1|NC_002677|Z95150|MTCY164_29 conserved
hypothetical protein from Mycobacterium leprae (100
aa),FASTA scores: opt: 647, E(): 0, (100.0% identity in
100 aa overlap). Also highly similar to M29612|SERCYSA_5
rhodanese-like protein from Saccharopolyspora erythraea
(101 aa), FASTA scores: opt: 345, E(): 1.2e-18, (57.1%
identity in 98 aa overlap); and similar at the C-terminus
to the C-terminus of CAB94069.1|AL358692 conserved
hypothetical protein from Streptomyces coelicolor (95 aa).
Identical second copy present as Rv3118|MTCY164.28|SSEC1
from Mycobacterium tuberculosis (100 aa) (100.0% identity
in 100 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0814c"
/db_xref="EnsemblGenomes-Tr:CCP43562"
/db_xref="GOA:P0CG95"
/db_xref="InterPro:IPR008969"
/db_xref="InterPro:IPR010814"
/db_xref="UniProtKB/Swiss-Prot:P0CG95"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43562.1"
/translation="MCSGPKQGLTLPASVDLEKETVITGRVVDGDGQAVGGAFVRLLD
SSDEFTAEVVASATGDFRFFAAPGSWTLRALSAAGNGDAVVQPSGAGIHEVDVKIT"
gene complement(908485..909318)
/gene="cysA2"
/gene_synonym="sseC4"
/locus_tag="Rv0815c"
CDS complement(908485..909318)
/codon_start=1
/transl_table=11
/gene="cysA2"
/gene_synonym="sseC4"
/locus_tag="Rv0815c"
/product="Probable thiosulfate sulfurtransferase CysA2
(rhodanese-like protein) (thiosulfate cyanide
transsulfurase) (thiosulfate thiotransferase)"
/note="Rv0815c, (MTV043.07c, MT0837, O05793), len: 277 aa.
Probable cysA2 (alternate gene name: sseC4), thiosulfate
sulfurtransferase (see Wooff et al., 2002), equivalent to
Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE putative
sulfurtransferase thiosulfate from Mycobacterium leprae
(277 aa). Also highly similar to other putative
thiosulfate sulfurtransferases e.g. P16385|THTR_SACER
putative thiosulfate sulfurtransferase from
Saccharopolyspora erythraea (Streptomyces erythraeus) (281
aa); NP_293941.1|NC_001263 thiosulfate sulfurtransferase
from Deinococcus radiodurans (286 aa); etc. Identical
second copy present as
Rv3117|MTCY164.27|MT3199|O05793|cysA3 (277 aa) (100.0%
identity in 277 aa overlap). Contains PS00683 Rhodanese
C-terminal signature at C-terminus. Belongs to the
rhodanese family."
/db_xref="EnsemblGenomes-Gn:Rv0815c"
/db_xref="EnsemblGenomes-Tr:CCP43563"
/db_xref="GOA:P9WHF9"
/db_xref="InterPro:IPR001307"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR036873"
/db_xref="PDB:3AAX"
/db_xref="PDB:3AAY"
/db_xref="PDB:3HWI"
/db_xref="UniProtKB/Swiss-Prot:P9WHF9"
/inference="protein motif:PROSITE:PS00683"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43563.1"
/translation="MARCDVLVSADWAESNLHAPKVVFVEVDEDTSAYDRDHIAGAIK
LDWRTDLQDPVKRDFVDAQQFSKLLSERGIANEDTVILYGGNNNWFAAYAYWYFKLYG
HEKVKLLDGGRKKWELDGRPLSSDPVSRPVTSYTASPPDNTIRAFRDEVLAAINVKNL
IDVRSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSRAANEDGTFKSDEELAKLY
ADAGLDNSKETIAYCRIGERSSHTWFVLRELLGHQNVKNYDGSWTEYGSLVGAPIELG
S"
gene complement(909611..910033)
/gene="thiX"
/locus_tag="Rv0816c"
CDS complement(909611..910033)
/codon_start=1
/transl_table=11
/gene="thiX"
/locus_tag="Rv0816c"
/product="Probable thioredoxin ThiX"
/note="Rv0816c, (MTV043.08c), len: 140 aa. Probable
thiX,thioredoxin, equivalent to ThiX|U15182|MLU15182_21
thioredoxin from Mycobacterium leprae (172 aa), FASTA
scores: opt: 556, E(): 8.8e-31, (63.8% identity in 141 aa
overlap); and similar to AAL08576.1|AF418548_2|AF418548
thioredoxin from Mycobacterium avium subsp.
paratuberculosis (117 aa). Also similar to other bacterial
thioredoxins e.g. CAB95303.1|AL359779 putative thioredoxin
from Streptomyces coelicolor (126 aa);
P33791|THIO_STRAU|TRX|TRXA thioredoxin from Streptomyces
aureofaciens (106 aa); etc. And similar to
Rv3914|MT4033|MTV028.05|NP_218431.1|NC_000962|trxC
thioredoxin (TRX) (MPT46) from Mycobacterium tuberculosis
(116 aa). Has hydrophobic stretch at N-terminus. Seems to
belong to the thioredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv0816c"
/db_xref="EnsemblGenomes-Tr:CCP43564"
/db_xref="GOA:I6Y8V2"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:I6Y8V2"
/protein_id="CCP43564.1"
/translation="MTTMIVASVATGALATIARWLLTRRSVILREVGPETTPAAPART
AELGLSGAGPTVVHFRAPGCAPCDRVRRGVGDVCADLGDVAHIEVDLDSNPQAARRFS
VLSLPTTLIFDVDGRQRYRTSGVPKAADLRSALKPLLA"
gene complement(910030..910842)
/locus_tag="Rv0817c"
CDS complement(910030..910842)
/codon_start=1
/transl_table=11
/locus_tag="Rv0817c"
/product="Probable conserved exported protein"
/note="Rv0817c, (MTV043.09c), len: 270 aa. Probable
conserved exported protein, with N-terminal signal
sequence, equivalent (but shorter 13 aa) to
U15182|MLU15182_22|U2266M probable exported protein from
Mycobacterium leprae (283 aa), FASTA scores: opt:
1287,E(): 0, (73.0% identity in 270 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0817c"
/db_xref="EnsemblGenomes-Tr:CCP43565"
/db_xref="InterPro:IPR021373"
/db_xref="UniProtKB/TrEMBL:I6WZH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43565.1"
/translation="MPMRKVLVGVTGAAIVVAVLIVGAVGADFGASIYAEYRLSTTVR
KAANLRSDPFVAILRFPFIPQAMREHYAELEIKAFAVEHAGSGTATLEATMHSIDLSY
ASWLIRPDAKLPVGELESRIIIDSMHLGRYLGISDLMVAAPRQESNDATGGTTESGIS
GSRGLVFSGTPISANFAHRVSVLVDLSVASDDRATLVITPTAVVTGPDTADQPVPDDK
RDAVLHAFASKLPNQKLPFGVVPNTVGARGSDVIIEGITRGVTISLDEFKQS"
gene 910972..911739
/locus_tag="Rv0818"
CDS 910972..911739
/codon_start=1
/transl_table=11
/locus_tag="Rv0818"
/product="Transcriptional regulatory protein"
/note="Rv0818, (MTV043.10), len: 255 aa. Probable
transcriptional regulatory protein, highly similar to
Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c
transcriptional regulatory protein from Streptomyces
coelicolor (267 aa), FASTA scores: opt: 945, E(): 0, (61.5
identity in 239 aa overlap); and similar to others from
other organisms. Also similar to Rv2884|MTCY274.15|Z74024
from Mycobacterium tuberculosis (252 aa), FASTA scores:
opt: 662, E(): 0, (47.8% identity in 226 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0818"
/db_xref="EnsemblGenomes-Tr:CCP43566"
/db_xref="GOA:O53830"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="PDB:4O1I"
/db_xref="UniProtKB/TrEMBL:O53830"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43566.1"
/translation="MLELLLLTSELYPDPVLPALSLLPHTVRTAPAEASSLLEAGNAD
AVLVDARNDLSSGRGLCRLLSSTGRSIPVLAVVSEGGLVAVSADWGLDEILLLSTGPA
EIDARLRLVVGRRGDLADQESLGKVSLGELVIDEGTYTARLRGRPLDLTYKEFELLKY
LAQHAGRVFTRAQLLHEVWGYDFFGGTRTVDVHVRRLRAKLGPEHEALIGTVRNVGYK
AVRPARGRPPAADPDDEDADPGRDGMQEPLVDPLRSQ"
gene 911736..912683
/gene="mshD"
/locus_tag="Rv0819"
CDS 911736..912683
/codon_start=1
/transl_table=11
/gene="mshD"
/locus_tag="Rv0819"
/product="GCN5-related N-acetyltransferase, MshD"
/note="Rv0819, (MTV043.11), len: 315 aa.
MshD,acetyltransferase involved in mycothiol synthesis
(see Koledin et al., 2002). Contains two GNAT
(Gcn5-related N-acetyltransferase) domains. See Vetting et
al. 2003,2005, 2006. Equivalent to
U2266N|U15182|MLU15182_24 hypothetical protein from
Mycobacterium leprae (312 aa),FASTA scores: opt: 1540,
E(): 0, (75.2% identity in 314 aa overlap). Also highly
similar to CAB88484.1|AL353816 putative acetyltransferase
from Streptomyces coelicolor (309 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0819"
/db_xref="EnsemblGenomes-Tr:CCP43567"
/db_xref="GOA:P9WJM7"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="InterPro:IPR017813"
/db_xref="PDB:1OZP"
/db_xref="PDB:1P0H"
/db_xref="PDB:2C27"
/db_xref="UniProtKB/Swiss-Prot:P9WJM7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43567.1"
/translation="MTALDWRSALTADEQRSVRALVTATTAVDGVAPVGEQVLRELGQ
QRTEHLLVAGSRPGGPIIGYLNLSPPRGAGGAMAELVVHPQSRRRGIGTAMARAALAK
TAGRNQFWAHGTLDPARATASALGLVGVRELIQMRRPLRDIPEPTIPDGVVIRTYAGT
SDDAELLRVNNAAFAGHPEQGGWTAVQLAERRGEAWFDPDGLILAFGDSPRERPGRLL
GFHWTKVHPDHPGLGEVYVLGVDPAAQRRGLGQMLTSIGIVSLARRLGGRKTLDPAVE
PAVLLYVESDNVAAVRTYQSLGFTTYSVDTAYALAGTDN"
gene 912726..913502
/gene="phoT"
/locus_tag="Rv0820"
CDS 912726..913502
/codon_start=1
/transl_table=11
/gene="phoT"
/locus_tag="Rv0820"
/product="Probable phosphate-transport ATP-binding protein
ABC transporter PhoT"
/note="Rv0820, (MTV043.12), len: 258 aa. Probable
phoT,phosphate-transport ATP-binding protein ABC
transporter (see citation below), equivalent to
PhoT|MLU15182_28|U15182 phosphate transport system ABC
transporter from Mycobacterium leprae (258 aa), FASTA
scores: opt: 1556,E(): 0, (91.5% identity in 258 aa
overlap). Also highly similar to others e.g.
CAB88472.1|AL353816 phosphate ABC transport system
ATP-binding protein from Streptomyces coelicolor (258 aa);
etc. Note that also highly similar to many PstB proteins
e.g. AAC15686.1|AF045938|PstB putative ABC transporter
nucleotide binding subunit from Mycobacterium smegmatis
(258 aa). Contains PS00211 ABC transporters family
signature and PS00017 ATP/GTP-binding site motif A
(P-loop). Belongs to the ATP-binding transport protein
family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv0820"
/db_xref="EnsemblGenomes-Tr:CCP43568"
/db_xref="GOA:P9WQL1"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005670"
/db_xref="InterPro:IPR015850"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQL1"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/protein_id="CCP43568.1"
/translation="MAKRLDLTDVNIYYGSFHAVADVSLAILPRSVTAFIGPSGCGKT
TVLRTLNRMHEVIPGARVEGAVLLDDQDIYAPGIDPVGVRRAIGMVFQRPNPFPAMSI
RNNVVAGLKLQGVRNRKVLDDTAESSLRGANLWDEVKDRLDKPGGGLSGGQQQRLCIA
RAIAVQPDVLLMDEPCSSLDPISTMAIEDLISELKQQYTIVIVTHNMQQAARVSDQTA
FFNLEAVGKPGRLVEIASTEKIFSNPNQKATEDYISGRFG"
gene complement(913558..914199)
/gene="phoY2"
/locus_tag="Rv0821c"
CDS complement(913558..914199)
/codon_start=1
/transl_table=11
/gene="phoY2"
/locus_tag="Rv0821c"
/product="Probable phosphate-transport system
transcriptional regulatory protein PhoY2"
/note="Rv0821c, (MTV043.13c), len: 213 aa. Probable
phoY2,phosphate-transport system regulatory protein,
highly similar to PhoY|MLU15182_29|U15182 phosphate
transport system regulator from Mycobacterium leprae (222
aa), FASTA scores: opt: 1268, E(): 0, (93.0% identity in
213 aa overlap). Also similar to others e.g.
NP_384620.1|NC_003047 probable phosphate transport system
transcriptional regulator protein from Sinorhizobium
meliloti (237 aa); etc. Also highly similar to
MTCI418A.03c|Z96070|PhoY1 probable phosphate transport
system transcriptional regulator protein from
Mycobacterium tuberculosis (221 aa),FASTA scores: opt:
937, E(): 0, (63.4% identity in 213 aa overlap). Belongs
to the PhoU family."
/db_xref="EnsemblGenomes-Gn:Rv0821c"
/db_xref="EnsemblGenomes-Tr:CCP43569"
/db_xref="GOA:P9WI95"
/db_xref="InterPro:IPR026022"
/db_xref="InterPro:IPR028366"
/db_xref="InterPro:IPR038078"
/db_xref="UniProtKB/Swiss-Prot:P9WI95"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43569.1"
/translation="MRTAYHEQLSELSERLGEMCGLAGIAMERATQALLQADLVLAEQ
VISDHEKIATLSARAEESAFVLLALQAPVAGDLRAIVSAIQMVADIDRMGALALHVAK
IARRRHPQHALPEEVNGYFAEMGRVAVELGNSAQEVVLSHDPEKAAQIREEDDAMDDL
HRHLFTVLMDREWKHGVAAAVDVTLLSRFYERFADHAVEVARRVIFQATGAFP"
gene complement(914257..916311)
/locus_tag="Rv0822c"
CDS complement(914257..916311)
/codon_start=1
/transl_table=11
/locus_tag="Rv0822c"
/product="Conserved protein"
/note="Rv0822c, (MTV043.14c), len: 684 aa. Conserved
protein, highly similar in the region between aa 370 - 580
to U2266O|U15182|MLU15182_30 hypothetical protein from
Mycobacterium leprae (222 aa), FASTA scores: opt: 819,
E(): 0, (60.6% identity in 221 aa overlap). More extended
similarity to Rv3267|Z92771|MTCY71_7 from Mycobacterium
tuberculosis (498 aa), FASTA scores: opt: 434, E():
2.2e-17, (26.6% identity in 541 aa overlap), and Rv3484.
Also similar to various proteins, preferiously putative
membrane proteins and membrane-bound regulatory proteins
e.g. CAC44512.1|AL596138 putative membrane protein from
Streptomyces coelicolor (524 aa); U56901|BSU56901_1
regulatory protein from Bacillus subtilis (391 aa), FASTA
scores: opt: 225, E(): 1.3e-05, (24.7% identity in 340 aa
overlap). Contains hydrophobic stretch (aa ~ 160-195) and
PS00041 Bacterial regulatory proteins, araC family
signature."
/db_xref="EnsemblGenomes-Gn:Rv0822c"
/db_xref="EnsemblGenomes-Tr:CCP43570"
/db_xref="InterPro:IPR004474"
/db_xref="InterPro:IPR027381"
/db_xref="UniProtKB/TrEMBL:I6WZI4"
/inference="protein motif:PROSITE:PS00041"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43570.1"
/translation="MSDGESAAPWARLSESAFPDGVDRWITVPPATWVAAQGPRDTQN
VGCHATGAVSVADLIARLGPAFPDLPTHRHVAPEPEPSGRGPKVHDDADDQQDTEAIA
IPAHSLEFLSELPDLRAANYPRADHARREPELPGKQLTGSARVRPLRIRRTSPAPAKP
APNSGRRPMVLAARSLAALFAALALALTGGAWQWSASKNSRLNMVSALDPHSGDIVNP
SGQHGDENFLLVGMDSRAGANANIGAGDAEDAGGARSDTVMLVNIPASRERVVAVSFP
RDLAITPIQCEAWNPETGKYGPIYDEKTGTMGPRLVYTETKLNSAFSFGGPKCLVKVI
QKLSGLSINRFIAIDFVGFARMVEALGGVEVCSTTPLRDYELGTVLEHAGRQVIDGPT
ALNYVRARQVTTESNGDYGRIKRQQLFLSSLLRSMISTDTLFNLSRLNNVVNMFIGNS
YVDNVKTKDLVELGRSLQHMAAGHVTFVTVPTGITDQNGDEPPRTSDMKALFTAIIDD
DPLPLENDHNAQRLGNTPSTPPTTTKKAPQAGLTNEIQHQQVTTTSPKEVTVQVSNST
GQAGLATTATDQLKRNGFNVMAPDDYPSSLLATTVFFSPGNEQAAATVAAVFGQSKIE
RVTGIGQLVQVVLGQDFSAVRAPLPSGSTVSVQISRNSSSPPTKLPEDLTVTNAADTT
CE"
gene complement(916477..917646)
/locus_tag="Rv0823c"
CDS complement(916477..917646)
/codon_start=1
/transl_table=11
/locus_tag="Rv0823c"
/product="Possible transcriptional regulatory protein"
/note="Rv0823c, (MTV043.15c), len: 389 aa. Possible
transcriptional regulator (resembles nitrogen regulation
protein), equivalent (but longer 24 aa in N-terminus) to
MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium
leprae (384 aa), FASTA scores: opt: 2070, E(): 0, (82.3%
identity in 384 aa overlap) (see citation below). Also
highly similar to CAB63312.1|AL133471|SCC82.03c
hypothetical protein from Streptomyces coelicolor (406
aa); and to many transcriptional regulators members of
UPF0034 family (NIFR3/SMM1) e.g. D26185|BAC180K_143
protein similar to transcriptional regulator (nitrogen
regulation protein) from Bacillus subtilis (333 aa), FASTA
scores: opt: 609,E(): 1.4e-32, (38.3% identity in 326 aa
overlap); NP_349795.1|NC_003030 NifR3 family enzyme from
Clostridium acetobutylicum (321 aa); etc. Contains PS01136
Uncharacterized protein family UPF0034 signature."
/db_xref="EnsemblGenomes-Gn:Rv0823c"
/db_xref="EnsemblGenomes-Tr:CCP43571"
/db_xref="GOA:P9WNS7"
/db_xref="InterPro:IPR001269"
/db_xref="InterPro:IPR004652"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR018517"
/db_xref="InterPro:IPR024036"
/db_xref="InterPro:IPR035587"
/db_xref="UniProtKB/Swiss-Prot:P9WNS7"
/inference="protein motif:PROSITE:PS01136"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43571.1"
/translation="MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQL
EQSKVGTVSGLYVCEMVTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAA
RMIAGEGLADHIDMNFGCPVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVT
VKFRIGIDDAHHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRT
IPVLGNGDIYDAGDALAMMSTTGCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTL
GEVADIIRRHGTLLAAHFGEDKGMRDIRKHIAWYLHGFPAGSALRRALAMVKTFDELD
CLLDRLDGTVPFPDSATGARGRQGSPARVALPDGWLTDPDDCRVPEGADAMGSGG"
gene complement(917734..918750)
/gene="desA1"
/gene_synonym="des"
/locus_tag="Rv0824c"
CDS complement(917734..918750)
/codon_start=1
/transl_table=11
/gene="desA1"
/gene_synonym="des"
/locus_tag="Rv0824c"
/product="Probable acyl-[acyl-carrier protein] desaturase
DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase)
(protein Des)"
/note="Rv0824c, (MTV043.16c), len: 338 aa. Probable desA1
(alternate gene name: des), acyl-[acyl-carrier protein]
desaturase (stearoyl-ACP desaturase) (see Jackson et
al.,1997), equivalent to U15182|MLU15182_32 acyl-[ACP]
desaturase from Mycobacterium leprae (338 aa), FASTA
scores: opt: 1880, E(): 0, (79.9% identity in 338 aa
overlap); and highly similar in part to fragment
CAB96061.1|AJ250019 Steroyl-ACP-desaturase from
Mycobacterium avium subsp. paratuberculosis (93 aa). Also
similar to other fatty acid desaturases e.g. T35035
probable acyl-[acyl-carrier protein] desaturase from
Streptomyces coelicolor (328 aa); Q40731|STAD_ORYSA
acyl-[acyl-carrier protein] desaturase precursor from
Oryza sativa (Rice) (390 aa); etc. Also highly similar to
desA2|Rv1094 from Mycobacterium tuberculosis (275 aa).
Contains PS00225 Crystallins beta and gamma 'Greek key'
motif signature. Belongs to the fatty acid desaturase
family. Cofactor: ferredoxin, ferredoxin NADPH
reductase,and NADPH. Predicted possible vaccine candidate
(See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0824c"
/db_xref="EnsemblGenomes-Tr:CCP43572"
/db_xref="GOA:P9WNZ7"
/db_xref="InterPro:IPR005067"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012348"
/db_xref="UniProtKB/Swiss-Prot:P9WNZ7"
/inference="protein motif:PROSITE:PS00225"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43572.1"
/translation="MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGK
NYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNR
WTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSV
LYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQ
AMKSLHLILSHFQMPGFQVPEFRRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFERE
DFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLA
MSRR"
gene 918264..918458
/gene="ASdes"
ncRNA 918264..918458
/gene="ASdes"
/product="Putative small regulatory RNA"
/note="ASdes, putative small regulatory RNA (See Arnvig
and Young, 2009). Alternate 5'-ends at positions 918350
and 918365. Alternate 3'-ends at positions 918432 and
918412."
/ncRNA_class="other"
gene complement(918912..919553)
/locus_tag="Rv0825c"
CDS complement(918912..919553)
/codon_start=1
/transl_table=11
/locus_tag="Rv0825c"
/product="Conserved protein"
/note="Rv0825c, (MTV043.17c), len: 213 aa. Conserved
protein, highly similar, but in part (between aa ~43-96)
to fadD27|Rv0275c|MTV035.03 putative fatty-acid-CoA ligase
from Mycobacterium tuberculosis (241 aa), FASTA scores:
E(): 7.3e-09, (32.6% identity in 190 aa overlap). Also
shows similarity with other proteins from Mycobacterium
tuberculosis e.g. Rv0078|AL0214|MTV030_22 (201 aa), FASTA
scores: opt:118, E(): 0.32, (34.5% identity in 113 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0825c"
/db_xref="EnsemblGenomes-Tr:CCP43573"
/db_xref="GOA:O53836"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:O53836"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43573.1"
/translation="MQTGQNRGRWSGVPLESRHALRRDNLVAAGVQLLGGAGGPALTV
RAVCRHAGLTERYFYESFADREHFVRAVYDDVCTRAMATLTSAQTPREAVEQFVELMV
DDPVRGRVLLLAPAVEPALTRSGAEWMPNFIELLQRKLSRIVDPVLQKLVATSLIGAL
TGLFTAYLNGRLGATRKQFIDYCVNMLLSTAATYAPHRERGESEHSIPAGPHN"
gene 919634..920689
/locus_tag="Rv0826"
CDS 919634..920689
/codon_start=1
/transl_table=11
/locus_tag="Rv0826"
/product="Conserved hypothetical protein"
/note="Rv0826, (MTV043.18), len: 351 aa. Conserved
hypothetical protein, similar to
CAB94053.1|AL358672|SC7A12.06 hypothetical protein from
Streptomyces coelicolor (300 aa); and
NP_421372.1|NC_002696 hypothetical protein from
Caulobacter crescentus (299 aa). Also similar to other
proteins from Mycobacterium tuberculosis e.g.
Rv1645c|Z85982|MTCY06H11.09 (351 aa),FASTA scores: opt:
1199, E(): 0, (57.5% identity in 299 aa overlap); Rv2237;
Rv0276; etc."
/db_xref="EnsemblGenomes-Gn:Rv0826"
/db_xref="EnsemblGenomes-Tr:CCP43574"
/db_xref="GOA:O53837"
/db_xref="InterPro:IPR018713"
/db_xref="UniProtKB/TrEMBL:O53837"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43574.1"
/translation="MTQDTSATCPLTSTVQDSSPVAGQLGRPIGFRGLAGGCPVSPLG
YESPPLPLGPDSLTWRYFGDWRGMLQGPWAGSMQNMHPQLGAAVEDHSTFFRERWPRL
LRSLYPIGGVVFDGDRAPVTGVQVRDYHITIKGVDGAGRRYHALNPDVFYWAHATFFV
GTLHVAERFCGGLTEAQRRQLFDEHVQWYRMYGMSMRPVPATWEEFQDYWDHMCRNVL
ENNFAARAVLDLTELPKPPFAQRVPDWLWAAPRKLLARFFVWLTVGLYDPPVRELMGY
RWLRRDEWLHRRFGDIVRLVFALVPFRFRKHPRARAGWDRATGRIPADAPLVQTPARN
LPPPDERDNPTHYCPKV"
gene complement(920741..921133)
/gene="kmtR"
/locus_tag="Rv0827c"
CDS complement(920741..921133)
/codon_start=1
/transl_table=11
/gene="kmtR"
/locus_tag="Rv0827c"
/product="Metal sensor transcriptional regulator KmtR
(ArsR-SmtB family)"
/note="Rv0827c, (MTV043.19c), len: 130 aa.
KmtR,transcriptional regulator (See Campbell et al.,
2007),similar to many e.g. CAC42856.1|AL592292 putative
regulatory protein from Streptomyces coelicolor (115 aa);
NP_301626.1|NC_002677 putative ArsR-family transcriptional
regulator from Mycobacterium leprae (140 aa);
BSUB0011_75|O31844|Z99114 YOZA protein from Bacillus
subtilis (107 aa), FASTA scores: opt: 208, E():
3.2e-08,(35.5% identity in 93 aa overlap); etc. Also
similar to MTCY27.22c|Z95208 from Mycobacterium
tuberculosis (135 aa),FASTA scores: opt: 201, E():
1.2e-07, (35.7% identity in 98 aa overlap). Contains
probable helix-turn helix motif from aa 42-63 (Score 1300,
+3.61 SD). Belongs to the ArsR family of transcriptional
regulators."
/db_xref="EnsemblGenomes-Gn:Rv0827c"
/db_xref="EnsemblGenomes-Tr:CCP43575"
/db_xref="GOA:O53838"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:O53838"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43575.1"
/translation="MYADSGPDPLPDDQVCLVVEVFRMLADATRVQVLWSLADREMSV
NELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLVIDAVFNAEH
AGPGIPRHHRAAGGLQSVAKASATKDVG"
gene complement(921191..921613)
/locus_tag="Rv0828c"
CDS complement(921191..921613)
/codon_start=1
/transl_table=11
/locus_tag="Rv0828c"
/product="Possible deaminase"
/note="Rv0828c, (MTV043.20c), len: 140 aa. Possible
deaminase, with its N-terminus highly similar to middle
part of NP_302602.1|NC_002677 possible
cytidine/deoxycytidylate deaminase from Mycobacterium
leprae (171 aa). Also similar to other deaminases e.g.
CAC18715.2|AL451182 putative deaminase from Streptomyces
coelicolor (167 aa); NP_251189.1|NC_002516 probable
deaminase from Pseudomonas aeruginosa (151 aa);
NP_108387.1|NC_002678 nitrogen fixation protein gene from
Mesorhizobium loti (149 aa); etc. Also similar to many
conserved hypothetical proteins e.g. NP_389200.1|NC_000964
hypothetical protein from Bacillus subtilis (156 aa),
FASTA scores: E(): 1.3e-07, (38.9% identity in 95 aa
overlap); etc. And similar to Rv3752c possible deaminase
from Mycobacterium tuberculosis. Contains PS00903 Cytidine
and deoxycytidylate deaminases zinc-binding region
signature. Belongs to the cytidine and deoxycytidylate
deaminases family."
/db_xref="EnsemblGenomes-Gn:Rv0828c"
/db_xref="EnsemblGenomes-Tr:CCP43576"
/db_xref="GOA:O53839"
/db_xref="InterPro:IPR002125"
/db_xref="InterPro:IPR016192"
/db_xref="InterPro:IPR016193"
/db_xref="UniProtKB/TrEMBL:O53839"
/inference="protein motif:PROSITE:PS00903"
/protein_id="CCP43576.1"
/translation="MPAGMAGFRRWAQTNDPTAHAESLAIRAACTKLGTEHLVGTTLN
VLAHPCPMCYGSLYYCSPDEVVFLTSRDAYEPHYVDDRRYFEPATFYDEFAKEWQDRR
LPMRQEHRPDIRAGAVDVYRFRQEPNGGERSAIAAPTG"
gene 921575..921865
/locus_tag="Rv0829"
CDS 921575..921865
/codon_start=1
/transl_table=11
/locus_tag="Rv0829"
/product="Possible transposase (fragment)"
/note="Rv0829, (MTV043.21), len: 96 aa. Possible
transposase for IS1605' (fragment), similar to C-terminal
end of many mycobacterial transposases and hypothetical
proteins e.g. Z74024|MTCY274_16 from Mycobacterium
tuberculosis (460 aa), FASTA scores: opt: 668, E():
6.2e-32, (98.9% identity in 93 aa overlap);
MTV002_57|O33333 transposase from Mycobacterium
tuberculosis ; L07627|SERRY1_1 insertion element IS1136
from Saccharopolyspora erythraea (90 aa), FASTA score:
(34.9% identity in 83 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0829"
/db_xref="EnsemblGenomes-Tr:CCP43577"
/db_xref="InterPro:IPR010095"
/db_xref="UniProtKB/TrEMBL:O53840"
/protein_id="CCP43577.1"
/translation="MGPSSKTCHACRHVQDIGWDEKWQCDGCSITHQRDDNAAINLAR
YEEPPSVVGPVGAAVKRGADRKTGPGPAGGREARKATGHPAGEQPRDGVLVA"
mobile_element 921575..921862
/mobile_element_type="insertion sequence:IS1605'"
/locus_tag="Rv0829"
/note="IS1605', len: 288 nt. Insertion sequence IS1605'."
gene 921970..922875
/locus_tag="Rv0830"
CDS 921970..922875
/codon_start=1
/transl_table=11
/locus_tag="Rv0830"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv0830, (MTV043.22), len: 301 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), member of Mycobacterium tuberculosis
protein family consisting of the proteins Rv0726c,
Rv0731c, Rv3399,Rv1729c|Z81360|MTCY4C12_14c (312 aa),
FASTA scores: opt: 1014, E(): 0, (54.1% identity in 292 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0830"
/db_xref="EnsemblGenomes-Tr:CCP43578"
/db_xref="GOA:P9WFI3"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFI3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43578.1"
/translation="MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAP
LVRAVGMDVYTRLVDWQIPVEGDSEFDPQRMATGMACRTRFFDQFFLDATHSGIGQFV
ILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATLSDLGAEPATERRTVAVDLRDD
WATALQTAGFDPKVPAAWSAEGLLVYLPVEAQDALFDNITALSAPGSRLAFEFVPDTA
IFADERWRNYHNRMSELGFDIDLNELVYHGQRGHVLDYLTRDGWQTSALTVTQLYEAN
GFAYPDDELATAFADLTYSSATLMR"
gene complement(922894..923709)
/locus_tag="Rv0831c"
CDS complement(922894..923709)
/codon_start=1
/transl_table=11
/locus_tag="Rv0831c"
/product="Conserved protein"
/note="Rv0831c, (MTV043.23c), len: 271 aa. Conserved
protein, similar to Rv0347|MTY13E10_7|Z95324 conserved
hypothetical protein from Mycobacterium tuberculosis (328
aa), FASTA scores: opt: 426, E(): 2.6e-21, (33.6% identity
in 262 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0831c"
/db_xref="EnsemblGenomes-Tr:CCP43579"
/db_xref="GOA:O53842"
/db_xref="InterPro:IPR026349"
/db_xref="UniProtKB/TrEMBL:O53842"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43579.1"
/translation="MLPETNQDEVQPNAPVALVTVEIRHPTTDSLTESANRELKHLLI
NDLPIERQAQDVSWGMTAPGGAPTPVADRFVRYVNRDNTTAASLKNQAIVVETTAYRS
FEAFTDVVMRVVDARAQVSSIVGLERIGLRFVLEIRVPAGVDGRITWSNWIDEQLLGP
QRFTPGGLVLTEWQGAAVYRELQPGKSLIVRYGPGMGQALDPNYHLRRITPAQTGPFF
LLDIDSFWTPSGGSIPEYNRDALVSTFQDLYGPAQVVFQEMITSRLKDELLRQ"
gene complement(923803..923875)
/gene="lysT"
tRNA complement(923803..923875)
/gene="lysT"
/product="tRNA-Lys"
/anticodon=(pos:complement(923840..923842),aa:Lys,seq:ttt)
/note="codon recognized: AAA; lysT, tRNA-Lys, anticodon
ttt, length = 73"
gene 923999..924072
/gene="gluT"
tRNA 923999..924072
/gene="gluT"
/product="tRNA-Glu"
/anticodon=(pos:924034..924036,aa:Glu,seq:ttc)
/note="codon recognized: GAA; gluT, tRNA-Glu, anticodon
ttc, length = 74"
gene 924110..924183
/gene="aspT"
tRNA 924110..924183
/gene="aspT"
/product="tRNA-Asp"
/anticodon=(pos:924144..924146,aa:Asp,seq:gtc)
/note="codon recognized: GAC; aspT, tRNA-Asp, anticodon
gtc, length = 74"
gene 924213..924286
/gene="pheU"
tRNA 924213..924286
/gene="pheU"
/product="tRNA-Phe"
/anticodon=(pos:924247..924249,aa:Phe,seq:gaa)
/note="codon recognized: UUC; pheU, tRNA-Phe, anticodon
gaa, length = 74"
gene 924951..925364
/gene="PE_PGRS12"
/locus_tag="Rv0832"
CDS 924951..925364
/codon_start=1
/transl_table=11
/gene="PE_PGRS12"
/locus_tag="Rv0832"
/product="PE-PGRS family protein PE_PGRS12"
/note="Rv0832, (MTV043.24), len: 137 aa. PE_PGRS12, Member
of the Mycobacterium tuberculosis PE family, possibly PGRS
subfamily of gly-rich proteins (see citation below),
highly similar to many others e.g. MTCY1A11.25c|Z78020
(498 aa),FASTA scores: opt: 529, E(): 5.2e-22, (61.8%
identity in 136 aa overlap); etc. Appears to have incurred
frameshift as next ORF should be continuation; sequence
has been checked but no error found."
/db_xref="EnsemblGenomes-Gn:Rv0832"
/db_xref="EnsemblGenomes-Tr:CCP43580"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FV8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43580.1"
/translation="MSYVSVLPATLATAATEVARIGSALSLASAVAAAQTSAVQAAAA
DEVSAAIAALFSAHGRDFQALSARAAAFHHEFVQALAAGAGSYAVAEIAAASPLQSLI
DVFNAPIQAATGRPLIGNGANGQPGTGAPGGPAGG"
gene 925361..927610
/gene="PE_PGRS13"
/locus_tag="Rv0833"
CDS 925361..927610
/codon_start=1
/transl_table=11
/gene="PE_PGRS13"
/locus_tag="Rv0833"
/product="PE-PGRS family protein PE_PGRS13"
/note="Rv0833, (MTV043.25), len: 749 aa. PE_PGRS13, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan and Delogu,
2002), but lacking N-terminal domain (present in preceding
ORF),possibly due to frameshift. Similar in part to many
others e.g. MTCY28_25|Z95890 (914 aa), FASTA scores: opt:
2726,E(): 0, (60.1% identity in 776 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0833"
/db_xref="EnsemblGenomes-Tr:CCP43581"
/db_xref="UniProtKB/TrEMBL:Q79FV7"
/protein_id="CCP43581.1"
/translation="MIGNGGAGGSGAPGAIGGAGGPAGLIGVGGAGGAGGDSAVAGVI
GGAGGAGGAALLFGAGGAGGAGGSGGSGAAGGAGGAGGAGGLFASGGSGGFGGFASTG
TGGAGGTGGAGGLFASGGVGGTGGGAGSGGTGGVGGTGGAGGLFASGGAGGAGGSGGT
GGAGGTGGAGGLFGAGGAGGLGGQGNHTGGHGGAGGSAGLLALGDGGAGGAGGAATTG
TGGAGGAGGKAGLLFGSGGAGGSGGAAGTFGDTGNSGGAGGAGGKAGLLFGSGGAGGS
GGAGGFANGSTGGAGGAGGGAGLIGNGGNGGSGGTSVATGGAGNGGAGGAGGGAGLIG
NGGNGGSGGMGDAPGGTGVGGIGGLLLGLDGANAPASTNPLHTAQQQALAAVNAPIQA
VTGRPLIGNGANGAPGSGAPGGHGGWLFGGGGTGGSGVSGGAGGDGGAGGILFGAGGA
GGAGGAVTGTGATGGSGGAGGGALLFGAGGAGGAGGSSGIGGFAAGGAGGPGGAGGLF
NGGGAGGAGGSGVSGGAGGEGGAGGAGGLFAGGGAGGAGGSGNNVGGAGGAGGVGGLF
GAGGAGGSGGGGSVAGDSGAGGNAGLLAPGLAGGAGGGGGQGFDTGGAGGPGGDAGLL
VGSGGVGGAGGFGLTTGGPGAAGGDAGLLFGSGGAGGAGGSGRTDLGGAGGAGGKAGL
IGNGGNGGAGGAGGNGGGDGGPGGAAFGLGNGGNGGNGGTGTSAGSPGAGGAGGSLIG
AEGLPGLLP"
gene complement(927837..930485)
/gene="PE_PGRS14"
/locus_tag="Rv0834c"
CDS complement(927837..930485)
/codon_start=1
/transl_table=11
/gene="PE_PGRS14"
/locus_tag="Rv0834c"
/product="PE-PGRS family protein PE_PGRS14"
/note="Rv0834c, (MTV043.26c), len: 882 aa.
PE_PGRS14,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002),highly similar to many others e.g.
MTCY493_4|Z95844 (1329 aa), FASTA scores: opt: 2577, E():
0, (52.0% identity in 950 aa overlap); etc. Thought to be
differentially expressed within host cells (see Triccas et
al., 1999)."
/db_xref="EnsemblGenomes-Gn:Rv0834c"
/db_xref="EnsemblGenomes-Tr:CCP43582"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FV6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43582.1"
/translation="MSFVIAAPDLVAMATEDLAGIGASLTAANAAAAVPTSGLLAAAG
DEVSAAIAALFSSHGQQYQAMSAQAAAFHARFVQALAGAMGAYAAAEAANASPLQTLE
QGLLGAINAPAAALSGRPFIGNGTNGAPGTGEAGGPGGWLLGNGGNGGSGAPGQTGGA
GGAAGLLGHGGTGGAGGTGASGGKGGTGGWLWGSGGAGGAGGSGGGSGGAGGNALMFG
IGGNGGAGGAASGVGNGGVGGAGGAGGALVAIGGAGGAGGAATTGTGGAGGAGSNALG
LFLGLGGSGGQGGDSAMGSGGAGGAGGSGGAASPFGIDIGIGGAGGHGGAGTNGGAGG
AGGAGGSSGTVFALDLSWGGAGGNGGAATTGTGGAGGTGGFAVAPDFIGFGAAYGGAG
GLGGAATGAGGTGGTGGVGAGGFAALGVGVGGAGGAGGAATETGGIGGAGGLGVGLLG
GAGGAGGPGGAASAGSGGHGGTGGDALGLIGAGIGGVGGVGGAATDTGGNGGAGGSGT
GLLGGVGGAGGHGGGASVGTGGSGGAGGDGFGFVGAGGNGGNAGTGVGVNGANGGNGG
SATGALAAVGGAGAAGGDATSGTGGFGGAGGSARGLIFALGGAGAAGGDASTGVGGPG
GPGGTGTASSPFGIAIAIGGAGAQGGAGTSGATGGAGGDGVFEGIAVLGLGFGGAAGA
GGAATGDGATGGAGGFGGAGAGIANFLGFSVLHGGAGGAGGTATGTGGNGGAGGGGGL
SSPVILGIGIGGAGGDGGGALGVLGGMGGDGGDGGEAVAVGIAVGGAGGAGGAAPTGN
GGAGGNGGDALGLVGVGGNGGNAGTGFGANTGGNGGDTTIVVNGMLAPSTLGYGGNGG
NGVNGGAGGTGGKAGVFGAPGQNGLP"
gene 930953..931597
/gene="lpqQ"
/locus_tag="Rv0835"
CDS 930953..931597
/codon_start=1
/transl_table=11
/gene="lpqQ"
/locus_tag="Rv0835"
/product="Possible lipoprotein LpqQ"
/note="Rv0835, (MTV043.27), len: 214 aa. Possible
lpqQ,lipoprotein. Contains PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0835"
/db_xref="EnsemblGenomes-Tr:CCP43583"
/db_xref="GOA:O53846"
/db_xref="InterPro:IPR026954"
/db_xref="UniProtKB/TrEMBL:O53846"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43583.1"
/translation="MCCSTAAKSAVIVCCAAIATTACSFQATSTQPSTAPPTSRVDSL
IVSIEDVRRIANYEELAAHFQTDLREPPEADTNVPGPCRVVGSSDRTFGTDWSEFRSA
GYHGVTDDLRPGGPVMVETVSQAIALYPDPSTARGVFHRLESSLAECAGLHDPYFDFI
LDRPDASTVRIGAAGWSHVYRLKSSVFISVGVLGIEPAEPIANVILQTISDRIQ"
gene complement(932279..932932)
/locus_tag="Rv0836c"
CDS complement(932279..932932)
/codon_start=1
/transl_table=11
/locus_tag="Rv0836c"
/product="Hypothetical protein"
/note="Rv0836c, (MTV043.29c), len: 217 aa (start
uncertain). Hypothetical unknown protein. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0836c"
/db_xref="EnsemblGenomes-Tr:CCP43584"
/db_xref="InterPro:IPR014513"
/db_xref="UniProtKB/TrEMBL:O53848"
/protein_id="CCP43584.1"
/translation="MLVGAQCRDLLHWRFCRGVPPRATNDTDIAGTLNNWDHFEAIRA
TFRALGSTGHRFLIADRAVDALPFGEVESPTGTTRHPPGNQLMNVHGCTDAYLRADVL
PLPGGLTVHLPQPPNYAVLKLHAWLDRSADHDYKDGPDLALVVHWYAGDLDRLYAKPD
QWALRRHDFDLRTAAAALLGHDMRASVSAPEAAVLATRATQADHDLLAQHFAVGRPG"
gene complement(933003..934031)
/locus_tag="Rv0837c"
CDS complement(933003..934031)
/codon_start=1
/transl_table=11
/locus_tag="Rv0837c"
/product="Hypothetical protein"
/note="Rv0837c, (MTV043.30c), len: 342 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0837c"
/db_xref="EnsemblGenomes-Tr:CCP43585"
/db_xref="InterPro:IPR016600"
/db_xref="InterPro:IPR019238"
/db_xref="UniProtKB/TrEMBL:I6Y4Y1"
/protein_id="CCP43585.1"
/translation="MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDA
HPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAG
NAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQL
VDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGG
LGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADL
LIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRR
QDERLARL"
gene 934720..935490
/gene="lpqR"
/locus_tag="Rv0838"
CDS 934720..935490
/codon_start=1
/transl_table=11
/gene="lpqR"
/locus_tag="Rv0838"
/product="Probable conserved lipoprotein LpqR"
/note="Rv0838, (MTV043.31), len: 256 aa. Probable
lpqR,conserved lipoprotein. Similar (except in N-terminus)
to hypothetical proteins and D-alanyl-D-alanine
dipeptidases e.g. NP_416005.1|NC_000913 hypothetical
protein from Escherichia coli strain K12 (193 aa);
NP_421076.1|NC_002696 D-alanyl-D-alanine dipeptidase from
Caulobacter crescentus (212 aa); Q06241|VANX_ENTFC
D-alanyl-D-alanine dipeptidase from Enterococcus faecium
(202 aa), FASTA scores: opt: 198,E(): 1.9e-05, (28.1%
identity in 199 aa overlap); etc. Contains signal sequence
and appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0838"
/db_xref="EnsemblGenomes-Tr:CCP43586"
/db_xref="GOA:O53850"
/db_xref="InterPro:IPR000755"
/db_xref="InterPro:IPR009045"
/db_xref="UniProtKB/TrEMBL:O53850"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43586.1"
/translation="MRLIGRLRLLMVGLVVICGACACDRVSAGRWSESPSATSWPVRP
VNTTTPSGPVPPVSEAARAAGLVDVRGVVPDAAIDLRYATANNFTGTQLYPPGARCLV
HESMAEGLAAAAAVLRPHGQVLVFWDCYRPHDVQVRMFDVVPNPAWVARPGKYAHSHE
AGRSVDVTFASAQRQCPSVRRSGELCLADMGTDFDDFSSRATAFATQGVSAEAQANRA
HLRAAMQAGGLTVYSGEWWHFDGPGAGVDRPILEVPVD"
gene 935577..936389
/locus_tag="Rv0839"
CDS 935577..936389
/codon_start=1
/transl_table=11
/locus_tag="Rv0839"
/product="Conserved hypothetical protein"
/note="Rv0839, (MTV043.32), len: 270 aa. Conserved
hypothetical protein, similar to various hypothetical
proteins or methyltransferases from yeast and bacteria
e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hypothetical
protein from Streptomyces coelicolor (273 aa), FASTA
scores: opt: 1102, E(): 0, (58.6% identity in 263 aa
overlap); T38024|Z98598|SPAC1B3.06c hypothetical protein
from Schizosaccharomyces pombe (278 aa), FASTA scores:
opt: 562,E(): 1.9e-3, (36.4% identity in 269 aa overlap);
JC6531 avermectin B 5-O-methyltransferase from
Streptomyces avermitilis (283 aa); etc. Also similar to
other Mycobacterium tuberculosis hypothetical proteins
that may be methyltransferases e.g. Rv1523, Rv2952,
Rv1405c, etc."
/db_xref="EnsemblGenomes-Gn:Rv0839"
/db_xref="EnsemblGenomes-Tr:CCP43587"
/db_xref="InterPro:IPR025714"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:I6X9X6"
/protein_id="CCP43587.1"
/translation="MNDKRRAIYTHGYHESVLRSHRRRTAENSAGYLLPYLVPGLSVL
DVGCGPGTITVDLAARVVPGSVTGVEPTDDALSLARAEAQLHRLSNISFTTSDVHKLD
FPDDAFDVVHAHQVLQHVADPVRALQEMRRVCTPGGIVAARDADYSGFIWFPKLPALD
RWLDLYERAARANGGEPDAGRRLLSWARAAGFDDVTPTASVWCFATASAREWWGLVWA
DRILQSDLAHQLVDSGLATAAQLEEISTAWREWAAAPDGWLAIPHGEILCRA"
gene complement(936457..937317)
/gene="pip"
/locus_tag="Rv0840c"
CDS complement(936457..937317)
/codon_start=1
/transl_table=11
/gene="pip"
/locus_tag="Rv0840c"
/product="Probable proline iminopeptidase Pip (prolyl
aminopeptidase) (pap)"
/note="Rv0840c, (MTV043.33c), len: 286 aa. Possible
pip,proline iminopeptidase, similar to many e.g.
P46541|PIP_BACCO proline iminopeptidase from bacillus
coagulans (288 aa), FASTA scores: opt: 657, E(): 0, (37.6%
identity in 282 aa overlap); NP_386922.1|NC_003047
putative proline iminopeptidase protein from Sinorhizobium
meliloti (296 aa); etc. Belongs to peptidase family S33."
/db_xref="EnsemblGenomes-Gn:Rv0840c"
/db_xref="EnsemblGenomes-Tr:CCP43588"
/db_xref="GOA:I6Y8X0"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR002410"
/db_xref="InterPro:IPR005945"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6Y8X0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43588.1"
/translation="MEGTIAVPGGRVWFQRIGGGPGRPLLVVHGGPGLPHNYLAPLRR
LSDEREVIFWDQLGCGNSACPSDVDLWTMNRSVAEMATVAEALALTRFHIFSHSWGGM
LAQQYVLDKAPDAVSLTIANSTASIPEFSASLVSLKSCLDVATRSAIDRHEAAGTTHS
AEYQAAIRTWNETYLCRTRPWPRELTEAFANMGTEIFETMFGPSDFRIVGNVRDWDVV
DRLADIAVPTLLVVGRFDECSPEHMREMQGRIAGSRLEFFESSSHMPFIEEPARFDRV
MREFLRLHDI"
gene 937593..937835
/locus_tag="Rv0841"
CDS 937593..937835
/codon_start=1
/transl_table=11
/locus_tag="Rv0841"
/product="Probable conserved transmembrane protein"
/note="Rv0841, len: 80 aa. Conserved transmembrane
protein,highly similar to C-terminus of next ORF
Rv0842|O53854 putative membrane protein from Mycobacterium
tuberculosis (442 aa), FASTA scores: opt: 246, E():
3.3e-10, (59.7% identity in 72 aa overlap). Replace
previous Rv0841c."
/db_xref="EnsemblGenomes-Gn:Rv0841"
/db_xref="EnsemblGenomes-Tr:CCP43589"
/db_xref="GOA:I6WZK3"
/db_xref="UniProtKB/TrEMBL:I6WZK3"
/protein_id="CCP43589.1"
/translation="MVAASIVHHSAAPANRGRYHGIWSMTPVVASVVVPIMASYGPIH
GAHLLAAVVVGSAGAALCLPLARALRRPTPSAMTTD"
gene 938112..939404
/locus_tag="Rv0842"
CDS 938112..939404
/codon_start=1
/transl_table=11
/locus_tag="Rv0842"
/product="Probable conserved integral membrane protein"
/note="Rv0842, (MT0864, MTV043.35), len: 430 aa. Probable
conserved integral membrane protein, showing similarity
with other integral membrane proteins e.g.
P28246|BCR_ECOLI bicyclomycin resistance protein from
EScherichia coli (396 aa), FASTA scores: opt: 216, E():
5.4e-07, (23.7% identity in 376 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0842"
/db_xref="EnsemblGenomes-Tr:CCP43590"
/db_xref="GOA:O53854"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O53854"
/protein_id="CCP43590.1"
/translation="MRYTGPERCSGDGQVRAAGDRYSTVIWLLGGNLLVRSAGFGYPF
LAYHVAGRGHGAGAVGAVVAAYGLGWAVGQLLCGWLVDRVGARVTLVSTMLVAAAVLV
LMAGLHTVPGLLVGAMIAGLVCDAPRPVLGAVIAELVADPQRRAQLDGWRYGWVLNIG
AAITGGVGGVVAGWLDTPVLYWINGIGCAIFAGLAGRCIPADVCRRTESGLRACTAMS
KVGYRQALSDKRLVLLAVSGLATLTTLMGFFAAVPMLMSASGLGVGAYGWVQLINALA
VVAVTPLLTPWLSKQLALGPRPDILAGAGVWVTLCMAAAGLARTTVGFSVAAAACSPG
EIAWFVVAAGIVHRIAPPAHGGRYHGIWSMAVAASSVAAPILAAFNLANGGRLVLAAT
TVTVGFFGAALCLPLARVLAAASCGPLSSKEPSRDSYQ"
gene 939388..940392
/locus_tag="Rv0843"
CDS 939388..940392
/codon_start=1
/transl_table=11
/locus_tag="Rv0843"
/product="Probable dehydrogenase"
/note="Rv0843, (MTV043.36), len: 334 aa. Probable
dehydrogenase, similar to various dehydrogenases e.g.
Q46142|Q46142 TPP-dependent acetoin dehydrogenase (326
aa),FASTA scores: opt: 500, E(): 2.4e-26, (32.3% identity
in 300 aa overlap); P51267|ODPA_PORPU pyruvate
dehydrogenase E1 component from Porphyra purpurea (344
aa), FASTA scores: opt: 451, E(): 4.7e-23, (29.6% identity
in 311 aa overlap); etc. Also similar to Rv2497c|pdhA
pyruvate dehydrogenase E1 component from Mycobacterium
tuberculosis (367 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0843"
/db_xref="EnsemblGenomes-Tr:CCP43591"
/db_xref="GOA:I6XWE5"
/db_xref="InterPro:IPR001017"
/db_xref="InterPro:IPR017596"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/TrEMBL:I6XWE5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43591.1"
/translation="MTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLING
PLQGGFGQEAVSVGAAAALGEGDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLE
GADEDAHIADPRAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADA
FNEAADLAAVWQLPVVILVENIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSVDGNDV
EAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFAR
RRLIAAGTTRGRLDEQERAACQQVADAVAFAKARARPNGGGPISRPTSGWHQQPKTRF
"
gene complement(940456..941106)
/gene="narL"
/locus_tag="Rv0844c"
CDS complement(940456..941106)
/codon_start=1
/transl_table=11
/gene="narL"
/locus_tag="Rv0844c"
/product="Possible nitrate/nitrite response
transcriptional regulatory protein NarL"
/note="Rv0844c, (MTV043.37c), len: 216 aa. Possible
narL,nitrate/nitrite response regulator protein, similar
to many e.g. CAB44989.1|AJ131854 NarL protein from
Pseudomonas stutzeri (218 aa); CAA75536.1|Y15252
nitrate/nitrite regulatory protein from Pseudomonas
aeruginosa (216 aa); PCC6803|D64005|SYCSLRG_24 NarL
protein from Synechocystis sp. (209 aa), FASTA scores:
opt: 438, E(): 1.5e-23, (34.6% identity in 208 aa
overlap); etc. Also similar to unidentified regulator e.g.
CAB76009.1|AL157916 putative two-component system response
regulator from Streptomyces coelicolor (224 aa); etc.
Contains probable helix-turn helix motif from aa 170-191
(Score 1124, +3.02 SD)."
/db_xref="EnsemblGenomes-Gn:Rv0844c"
/db_xref="EnsemblGenomes-Tr:CCP43592"
/db_xref="GOA:P9WGM5"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR016032"
/db_xref="PDB:3EUL"
/db_xref="UniProtKB/Swiss-Prot:P9WGM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43592.1"
/translation="MSNPQPEKVRVVVGDDHPLFREGVVRALSLSGSVNVVGEADDGA
AALELIKAHLPDVALLDYRMPGMDGAQVAAAVRSYELPTRVLLISAHDEPAIVYQALQ
QGAAGFLLKDSTRTEIVKAVLDCAKGRDVVAPSLVGGLAGEIRQRAAPVAPVLSARER
EVLNRIACGQSIPAIAAELYVAPSTVKTHVQRLYEKLGVSDRAAAVAEAMRQRLLD"
gene 941190..942467
/locus_tag="Rv0845"
CDS 941190..942467
/codon_start=1
/transl_table=11
/locus_tag="Rv0845"
/product="Possible two component sensor kinase"
/note="Rv0845, (MTV043.38), len: 425 aa. Possible
two-component sensor kinase, with its C-terminus similar
to C-terminal part of others e.g. NP_294951.1|NC_001263
two-component sensor histidine kinase from Deinococcus
radiodurans (469 aa); CAC32293.1|AL583943 putative two
component system histidine kinase from Streptomyces
coelicolor (404 aa); NP_464546.1|NC_003210 protein similar
to two-component sensor histidine kinase from Listeria
monocytogenes (352 aa); BSUB0017_193|Z9912 two-component
sensor kinase from Bacillus subtilis (360 aa), FASTA
scores: opt: 275, E(): 1.6e-11, (30.3% identity in 234 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0845"
/db_xref="EnsemblGenomes-Tr:CCP43593"
/db_xref="GOA:O53857"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:O53857"
/protein_id="CCP43593.1"
/translation="MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIAS
VLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFR
SMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACT
LVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALR
AELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQ
SASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIV
FGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGL
ASHRARVDAAGGVLVFLATPRGTHVCVELPLKR"
gene complement(942680..944194)
/locus_tag="Rv0846c"
CDS complement(942680..944194)
/codon_start=1
/transl_table=11
/locus_tag="Rv0846c"
/product="Probable oxidase"
/note="Rv0846c, (MTV043.39c), len: 504 aa. Probable
oxidase, showing similarity with several oxidases, mainly
L-ascorbate oxidases and copper resistance proteins a
(precursors) e.g. P24792|ASO_CUCMA L-ascorbate oxidase
precursor (ascorbase) from Cucurbita maxima (Pumpkin)
(Winter squash) (579 aa), FASTA scores: opt: 423, E():
5.8e-18, (28.4% identity in 493 aa overlap);
AF010496|AF010496_32 potential multicopper oxidase from
Rhodobacter capsulatus (491 aa), FASTA scores: opt:
490,E(): 2.7e-22, (28.8% identity in 510 aa overlap);
47452|PCOA_ECOLI copper resistance protein A precursor
(belongs to the family of multicopper oxidases) from
Escherichia coli strain K12 (605 aa); etc. Contains
PS00080 Multicopper oxidases signature 2 at C-terminus.
Seems to belong to the family of multicopper oxidases."
/db_xref="EnsemblGenomes-Gn:Rv0846c"
/db_xref="EnsemblGenomes-Tr:CCP43594"
/db_xref="GOA:I6WZK7"
/db_xref="InterPro:IPR001117"
/db_xref="InterPro:IPR002355"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR008972"
/db_xref="InterPro:IPR011706"
/db_xref="InterPro:IPR011707"
/db_xref="InterPro:IPR033138"
/db_xref="InterPro:IPR034279"
/db_xref="UniProtKB/Swiss-Prot:I6WZK7"
/inference="protein motif:PROSITE:PS00080"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43594.1"
/translation="MPELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGA
AGMTAAIDAAEAARPHSGRTVTATLTPQPARIDLGGPIVSTLTYGNTIPGPLIRATVG
DEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWA
HPHVGLQGDHGLYLPVVVDDPTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNK
PTMQNTTGMPEGEGVDSNLLGGDGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRII
NSAADTAFRIALAGHSMTVTHTDGYPVIPTEVDALLIGMAERYDVMVTAAGGVFPLVA
LAEGKNALARALLSTGAGSPPDPQFRPDELNWRVGTVEMFTAATTANLGRPEPTHDLP
VTLGGTMAKYDWTINGEPYSTTNPLHVRLGQRPTLMFDNTTMMYHPIHLHGHTFQMIK
ADGSPGARKDTVIVLPKQKMRAVLVADNPGVWVMHCHNNYHQVAGMATRLDYIL"
gene 944343..944735
/gene="lpqS"
/locus_tag="Rv0847"
CDS 944343..944735
/codon_start=1
/transl_table=11
/gene="lpqS"
/locus_tag="Rv0847"
/product="Probable lipoprotein LpqS"
/note="Rv0847, (MTV043.40), len: 130 aa. Probable
lpqS,lipoprotein. Contains possible signal sequence and
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site."
/db_xref="EnsemblGenomes-Gn:Rv0847"
/db_xref="EnsemblGenomes-Tr:CCP43595"
/db_xref="GOA:O53859"
/db_xref="UniProtKB/Swiss-Prot:O53859"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP43595.1"
/translation="MVWMRSAIVAVALGVTVAAVAAACWLPQLHRHVAHPNHPLTTSV
GSEFVINTDHGHLVDNSMPPCPERLATAVLPRSATPVLLPDVVAAAPGMTAALTDPVA
PAARGPPAAQGSVRTGQDLLTRFCLARR"
gene 944938..946056
/gene="cysK2"
/gene_synonym="cysM3"
/locus_tag="Rv0848"
CDS 944938..946056
/codon_start=1
/transl_table=11
/gene="cysK2"
/gene_synonym="cysM3"
/locus_tag="Rv0848"
/product="Possible cysteine synthase a CysK2
(O-acetylserine sulfhydrylase) (O-acetylserine
(thiol)-lyase) (CSASE)"
/note="Rv0848, (MTV043.41), len: 372 aa. Possible
cysK2,cysteine synthase A, but could be also a cysteine
synthase B cysM2-product, similar to many e.g.
NP_109408.1|NC_002682 cysteine synthase from Mesorhizobium
loti (357 aa); Q44004|CYSM_ALCEU cysteine synthase from
Alcaligenes eutrophus strain CH34 (Ralstonia eutropha)
(339 aa), FASTA scores: opt: 511, E(): 1.7e-25, (35.0%
identity in 314 aa overlap); etc. Belongs to the cysteine
synthase/cystathionine beta-synthase family. Cofactor:
pyridoxal phosphate. Note that previously known as cysM3."
/db_xref="EnsemblGenomes-Gn:Rv0848"
/db_xref="EnsemblGenomes-Tr:CCP43596"
/db_xref="GOA:Q79FV4"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR036052"
/db_xref="UniProtKB/Swiss-Prot:Q79FV4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43596.1"
/translation="MRSRQTRDRYRLLPEGYQVTPGRNRHPGTMVGNTPVLWIPELSG
TSDPDRGFWAKLEGFNPGGMKDRPALYMVECARARGDIAPGAAIVESTGGTLGLGLAL
AGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMVTQPHPVGGWQQARKDRVAQLMAE
YPGAWNPNQYGNPDNVGAYRSLALELVAQLGRIDVLVCSVGTGGHSAGVARVLREFNP
DMRLIGVDTIGSTIFGQPASNRLMRGLGSSIYPRNVDYRAFDEVHWVAPPEAVWACRS
LAATHYASGGWSVGAVALVAGWAARNLPADTTIAAVFPDGPQRYFDTIYNDAYCNEHE
LLGGQPPTEPDEIASPLDAVVTRWTRSTTVIDPTQVVS"
gene 946056..947315
/locus_tag="Rv0849"
CDS 946056..947315
/codon_start=1
/transl_table=11
/locus_tag="Rv0849"
/product="Probable conserved integral membrane transport
protein"
/note="Rv0849, (MTV043.42), len: 419 aa. Probable
conserved integral membrane transport protein, possibly
member of major facilitator superfamily (MFS) involved in
transport of drug, showing similarity with others e.g.
T35055 probable transport system permease protein from
Streptomyces coelicolor (436 aa); NP_295031.1|NC_001263
major facilitator family protein from Deinococcus
radiodurans (458 aa); NP_455659.1|NC_003198 putative
membrane transporter from Salmonella enterica subsp.
enterica serovar Typhi (402 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0849"
/db_xref="EnsemblGenomes-Tr:CCP43597"
/db_xref="GOA:P9WJX5"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJX5"
/protein_id="CCP43597.1"
/translation="MGARAIFRGFNRPSRVLMINQFGINIGFYMLMPYLADYLAGPLG
LAAWAVGLVMGVRNFSQQGMFFVGGTLADRFGYKPLIIAGCLIRTGGFALLVVAQSLP
SVLIAAAATGFAGALFNPAVRGYLAAEAGERKIEAFAMFNVFYQSGILLGPLVGLVLL
ALDFRITVLAAAGVFGLLTVAQLVALPQHRADSEREKTSILQDWRVVVRNRPFLTLAA
AMTGCYALSFQIYLALPMQASILMPRNQYLLIAAMFAVSGLVAVGGQLRITRWFAVRW
GAERSLVVGATILAASFIPVAVIPNGQRFGVAVAVMALVLSASLLAVASAALFPFEMR
AVVALSGDRLVATHYGFYSTIVGVGVLVGNLAIGSLMSAARRLNTDEIVWGGLILVGI
VAVAGLRRLDTFTSGSQNMTGRWAAPR"
mobile_element 947311..947641
/mobile_element_type="insertion sequence:IS1606'"
/note="IS1606', len: 331 nt. Insertion sequence IS1606'"
gene 947312..947644
/locus_tag="Rv0850"
CDS 947312..947644
/codon_start=1
/transl_table=11
/locus_tag="Rv0850"
/product="Putative transposase (fragment)"
/note="Rv0850, (MTV043.43), len: 110 aa. Putative
transposase (fragment), similar in part to others e.g.
Q45144|Q4514 transposable element IS31831 (436 aa), FASTA
scores: opt: 175, E(): 4.3e-05, (38.6% identity in 57 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0850"
/db_xref="EnsemblGenomes-Tr:CCP43598"
/db_xref="UniProtKB/TrEMBL:I6Y8X8"
/protein_id="CCP43598.1"
/translation="MTRDPHSPDCGREGSYRDTITRPLTDLPVAGYPLVPRVASPRYR
CTTPQCGRAVFNQDLANVDQYLVVNQLAHQLIDGSSLIPDADKRWDARRHADMTHHLT
SSLKENQS"
gene complement(947641..948468)
/locus_tag="Rv0851c"
CDS complement(947641..948468)
/codon_start=1
/transl_table=11
/locus_tag="Rv0851c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv0851c, (MTV043.44c), len: 275 aa. Probable
short-chain dehydrogenase/reductase, similar to many e.g.
Q01198|LIGD_PSEPA C alpha-dehydrogenase (SDR family) from
Pseudomonas paucimobilis (Sphingomonas paucimobilis) (305
aa); D11473|PSELIG_1 C alpha-dehydrogenase from P.
paucimobilis (305 aa), FASTA scores: opt: 468, E():
4.9e-23, (30.8% identity in 279 aa overlap);
NP_421969.1|NC_002696 short chain dehydrogenase family
protein from Caulobacter crescentus (278 aa); etc.
Contains PS00061 Short-chain dehydrogenases/reductases
family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv0851c"
/db_xref="EnsemblGenomes-Tr:CCP43599"
/db_xref="GOA:O53863"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53863"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43599.1"
/translation="MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLR
QAVNHLRAEGFDVHSVMCDVRHREEVTHLADEAFRLLGHVDVVFSNAGIVVGGPIVEM
THDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAK
YGVVGLAETLAREVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLP
LQDDNLGVDDIAQLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH"
gene 948559..949395
/gene="fadD16"
/locus_tag="Rv0852"
CDS 948559..949395
/codon_start=1
/transl_table=11
/gene="fadD16"
/locus_tag="Rv0852"
/product="Possible fatty-acid-CoA ligase FadD16
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv0852, (MTV043.45), len: 278 aa. Possible
fadD16,fatty-acid-CoA synthetase, similar in part to
various CoA ligases e.g. P18163|LCFB_RAT
long-chain-fatty-acid--CoA ligase from Rattus norvegicus
(Rat) (699 aa); D49366|LEP4CCOALA_1 4-coumarate:CoA ligase
from Lithospermum erythrorhizon (636 aa), FASTA scores:
opt: 134, E(): 0.15, (26.8% identity in 213 aa overlap);
orgp|L09229|HUMFACAL_1 long-chain acyl-coenzyme A from
homo sapiens (human) (699 aa), FASTA score: (50.0%
identity in 40 aa overlap); etc. Contains PS00626
Regulator of chromosome condensation (RCC1) signature 2."
/db_xref="EnsemblGenomes-Gn:Rv0852"
/db_xref="EnsemblGenomes-Tr:CCP43600"
/db_xref="GOA:I6Y4Z4"
/db_xref="UniProtKB/TrEMBL:I6Y4Z4"
/inference="protein motif:PROSITE:PS00626"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43600.1"
/translation="MFTIGYSCASRGADSWLIRRCSVVQGCLDDPGATVEAIDDDGWP
HTGDPCSPNSAASGKYGERPASVSTGDIHSLVIASDYRVPDPGRVWPLLQRNKSALAD
IGAHHVLIYASTHDSGRVLVMIGVRSREPIVELLRSRVFFDWFDAMGVDDIPAVFAGE
IVDRFVAAPTTTQSTPRVPGVVVAAFASVNNVSNLTAEVRSAIARFTAAGIRKTWVFQ
AFDDAHEVLILQEFADEAGARQWIEHPDAAAEWMSGAGVGAYPPLFVGRFFDMMRIEA
LQ"
gene complement(949436..951118)
/gene="pdc"
/locus_tag="Rv0853c"
CDS complement(949436..951118)
/codon_start=1
/transl_table=11
/gene="pdc"
/locus_tag="Rv0853c"
/product="Probable pyruvate or indole-3-pyruvate
decarboxylase Pdc"
/note="Rv0853c, (MTV043.46c), len: 560 aa. Probable
pdc,pyruvate or indole-pyruvate decarboxylase, equivalent
to NP_302424.1|NC_002677 pyruvate (or indolepyruvate)
decarboxylase from Mycobacterium leprae (569 aa). Also
highly similar to others e.g. AAB06571.1|L80006
indolepyruvate decarboxylase from Pantoea agglomerans (550
aa); Q12629|DCPY_KLULA pyruvate decarboxylase from
Kluyveromyces marxianus var. lactis (563 aa); P71323
indolepyruvate decarboxylase from Enterobacter herbicola
(550 aa), FASTA scores: opt: 1642, E(): 0, (48.1% identity
in 547 aa overlap); P23234|DCIP_ENTCL indole-3-pyruvate
decarboxylase (indolepyruvate decarboxylase) from
Enterobacter cloacae (552 aa), FASTA scores: opt:
1596,E(): 0, (46.8% identity in 551 aa overlap); etc.
Contains PS00187 Thiamine pyrophosphate enzymes signature
and PS00017 ATP/GTP-binding site motif A (P-loop).
Cofactor: thiamine pyrophosphate."
/db_xref="EnsemblGenomes-Gn:Rv0853c"
/db_xref="EnsemblGenomes-Tr:CCP43601"
/db_xref="GOA:P9WG37"
/db_xref="InterPro:IPR000399"
/db_xref="InterPro:IPR011766"
/db_xref="InterPro:IPR012000"
/db_xref="InterPro:IPR012001"
/db_xref="InterPro:IPR012110"
/db_xref="InterPro:IPR029035"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/Swiss-Prot:P9WG37"
/inference="protein motif:PROSITE:PS00187"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43601.1"
/translation="MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFL
DHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEH
VPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDR
VLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADH
QLTVLADLLVHRLQAVKELEALLAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAE
RVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSA
ALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLA
DQGTSFYGMADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQ
LTVQELGTFSREGLSPVIVVVNNDGYTVERAIHGETAPYNDIVSWNWTELPSALGVTN
HLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ"
gene 951183..951626
/locus_tag="Rv0854"
CDS 951183..951626
/codon_start=1
/transl_table=11
/locus_tag="Rv0854"
/product="Conserved protein"
/note="Rv0854, (MTV043.47), len: 147 aa. Conserved
protein,similar to several hypothetical protein from
Mycobacterium leprae e.g. NP_301674.1|NC_002677 (144 aa);
NP_302683.1|NC_002677|Z95398|MLCL622.27c (156 aa), FASTA
scores: opt: 193, E(): 1.6e-06, (24.6% identity in 134 aa
overlap); NP_301218.1|NC_002677 (146 aa); MTCI28.04|Z97050
(184 aa), FASTA scores: opt: 171, E(): 5.8e-05, (21.5%
identity in 135 aa overlap). Also similar to
SC6G10.02c|T35511|AL049497|SC6G10_2 hypothetical protein
from Streptomyces coelicolor (144 aa), FASTA scores: opt:
344, E(): 6.1e- 17, (37.6% identity in 141 aa overlap).
And similar to many proteins from Mycobacterium
tuberculosis e.g. downstreams ORFs Rv0856 and Rv0857,
etc."
/db_xref="EnsemblGenomes-Gn:Rv0854"
/db_xref="EnsemblGenomes-Tr:CCP43602"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:I6X9Y7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43602.1"
/translation="MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETG
DDGRPSKVKMKVKTAGITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGDNT
LVQFEITVDPQVPLPGFVLKRAIKGTIDTATEALRSQVLKVKKGQ"
gene 951632..952711
/gene="far"
/locus_tag="Rv0855"
CDS 951632..952711
/codon_start=1
/transl_table=11
/gene="far"
/locus_tag="Rv0855"
/product="Probable fatty-acid-CoA racemase Far"
/note="Rv0855, (MTV043.48), len: 359 aa. Probable
far,fatty acid-CoA racemase, highly similar to
CAB08122.1|Z94723 unknown protein from Mycobacterium
leprae (253 aa) (C-terminus shorter). Also similar to many
eukaryotic and bacteria racemases e.g. T35425 probable
fatty acid CoA racemase from Streptomyces coelicolor (387
aa); P70473|AMAC_RAT alpha-methylacyl-CoA racemase
(2-methylacyl-CoA racemase) (2-arylpropionyl-CoA
epimerase) from Rattus norvegicus (Rat) (382 aa);
NP_103687.1|NC_002678 probable fatty acid Co-a racemase
from Mesorhizobium loti (389 aa); etc. Also similar to
proteins from Mycobacterium tuberculosis e.g.
Rv1143|MTCI65.10|MCR from Mycobacterium tuberculosis (360
aa), FASTA scores: opt: 1373, E(): 0, (56.8% identity in
359 aa overlap), Rv1866|MTCY359.07 (C-terminal half) (778
aa), Rv3272 (360 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0855"
/db_xref="EnsemblGenomes-Tr:CCP43603"
/db_xref="GOA:I6Y8Y0"
/db_xref="InterPro:IPR003673"
/db_xref="InterPro:IPR023606"
/db_xref="UniProtKB/TrEMBL:I6Y8Y0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43603.1"
/translation="MTTGGPLAGVKVIELGGIGPGPHAGMVLADLGADVVRVRRPGGL
TMPSEDRDLLHRGKRIVDLDVKTQPQAMLELAAKADVLLDCFRPGTCERLGIGPDDCA
SVNPRLIFARITGWGQDGPLASTAGHDINYLSQTGALAAFGYADRPPMPPLNLVADFG
GGSMLVLLGIVVALYERERSGVGQVVDAAMVDGVSVLAQMMWTMKGIGSLRDQRESFL
LDGGAPFYRCYETSDGKYMAVGAIEPQFFAALLSGLGLSAADVPTQLDVAGYPQMYDI
FAERFASRTRDEWTRVFAGTDACVTPVLAWSEAANNDHLKARSTVITAHGVQQAAPAP
RFSRTPAGPVRPPPAAATPIDEINW"
gene 952825..953229
/locus_tag="Rv0856"
CDS 952825..953229
/codon_start=1
/transl_table=11
/locus_tag="Rv0856"
/product="Conserved hypothetical protein"
/note="Rv0856, (MTV043.49), len: 134 aa. Conserved
hypothetical protein, showing weak similarity with
NP_301674.1| (NC_002677) conserved hypothetical protein
from Mycobacterium leprae (144 aa); and SC6G10.02c|T35511
hypothetical protein from Streptomyces coelicolor (144
aa). Also highly similar to other proteins from
Mycobacterium tuberculosis e.g. neighbouring ORF
downstream Rv0857 conserved hypothetical protein (126 aa),
FASTA scores: E(): 7.4e-27, (62.0% identity in 100 aa
overlap); neighbouring ORF Rv0854|MTV043_47 conserved
hypothetical protein (147 aa), FASTA scores: E(): 1.6e-15,
(36.6% identity in 123 aa overlap),
MTCI28.04|Z97050|MTCI28_4 (184 aa), FASTA scores: opt:
127, E(): 0.036, (26.0% identity in 127 aa overlap); and
MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 123,E():
0.06, (26.4% identity in 125 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0856"
/db_xref="EnsemblGenomes-Tr:CCP43604"
/db_xref="InterPro:IPR005031"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O53868"
/protein_id="CCP43604.1"
/translation="MEALADVGVLASWSPLHKQVEVIDYYPDGRPHHVRATVKILGLV
DKEVLEYHWGPDWVCWDADQTFQQHGQHIEYTVKPEGVDRARVRFDITVEPAGPIPGF
IVKRASEHVLDAAAKGLQKLIAGAGDQGNAKS"
gene 953257..953730
/locus_tag="Rv0857"
CDS 953257..953730
/codon_start=1
/transl_table=11
/locus_tag="Rv0857"
/product="Conserved hypothetical protein"
/note="Rv0857, (MTV043.50), len: 157 aa. Conserved
hypothetical protein, showing weak similarity with
Q9X7Y8|SC6G10.02c|T35511 hypothetical protein from
Streptomyces coelicolor (144 aa), FASTA scores: opt:
215,E(): 7.6e-08, (30.282% identity in 142 aa overlap).
Also highly similar to other proteins from Mycobacterium
tuberculosis e.g. upstream ORF Rv0856 (134 aa), FASTA
scores: opt: 566, E(): 2e-32, (58.15% identity in 129 aa
overlap); upstream ORF Rv0854 (147 aa), FASTA scores: opt:
401, E(): 7.2e-21, (41.8% identity in 146 aa overlap);
MTCI28.04|Z97050 (184 aa), FASTA scores: opt: 122, E():
0.031, (29.4% identity in 85 aa overlap); and
MLCL622.27c|Z95398 (156 aa), FASTA scores: opt: 114, E():
0.1, (30.9% identity in 55 aa overlap). Length extended
since first submission (+33 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0857"
/db_xref="EnsemblGenomes-Tr:CCP43605"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:I6Y4Z9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43605.1"
/translation="MIANLVAVAIRASREVVIEAPPEVIVEALADMDAVPSWSSVHKR
VEVVDTYSDGRPHHVKVTIKVAGIVDTELLEYHWGPDWVVWDAAKTAQQHGQHGEYNL
RREDNDKTRVRFTLTVEPSAPLPAFWVNIARKKILHAATEGLRKQVVGRRRFTSG"
gene complement(953727..954920)
/gene="dapC"
/locus_tag="Rv0858c"
CDS complement(953727..954920)
/codon_start=1
/transl_table=11
/gene="dapC"
/locus_tag="Rv0858c"
/product="Probable N-succinyldiaminopimelate
aminotransferase DapC (DAP-at)"
/note="Rv0858c, (MTV043.51c), len: 397 aa. Probable
dapC,N-succinyldiaminopimelate aminotransferase, highly
similar to others from Eukaryota and bacteria, especially
aspartate aminotransferases (transaminases), e.g.
NP_177890.1|NC_003070 putative aminotransferase from
Arabidopsis thaliana (440 aa); NP_419555.1|NC_002696
aminotransferase class I from Caulobacter crescentus (385
aa); NP_415133.1|NC_000913|AE0001|ECAE000165_8 putative
aminotransferase from Escherichia coli strain K12 (386
aa),FASTA scores: opt: 830, E(): 0, (38.0% identity in 389
aa overlap); X99521|TAX99521_1 aspartate aminotransferase
from Thermus aquaticus (383 aa), FASTA scores: opt: 702,
E(): 0,(34.9% identity in 393 aa overlap); etc. Also
similar to other putative aminotransferases from
Mycobacterium tuberculosis e.g. Rv2294, Rv3565, etc."
/db_xref="EnsemblGenomes-Gn:Rv0858c"
/db_xref="EnsemblGenomes-Tr:CCP43606"
/db_xref="GOA:P9WPZ5"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="PDB:2O0R"
/db_xref="UniProtKB/Swiss-Prot:P9WPZ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43606.1"
/translation="MTVSRLRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQ
AAQDAIAGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAV
LGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVPDGRGFALDADALRRAVTPRT
RALIINSPHNPTGAVLSATELAAIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFD
GMAERTITISSAAKMFNCTGWKIGWACGPAELIAGVRAAKQYLSYVGGAPFQPAVALA
LDTEDAWVAALRNSLRARRDRLAAGLTEIGFAVHDSYGTYFLCADPRPLGYDDSTEFC
AALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHLVRFTFCKRDDTLDEAIRRLSVLA
ERPAT"
gene 955077..956288
/gene="fadA"
/locus_tag="Rv0859"
CDS 955077..956288
/codon_start=1
/transl_table=11
/gene="fadA"
/locus_tag="Rv0859"
/product="Possible acyl-CoA thiolase FadA"
/note="Rv0859, (MTV043.52), len: 403 aa. Possible
fadA,acyl-CoA thiolase, equivalent to
NP_302423.1|NC_002677 putative beta-ketoadipyl CoA
thiolase from Mycobacterium leprae (403 aa). Also highly
similar to acyl/acetyl-CoA thiolases and beta-ketoadipyl
CoA thiolases, e.g. T35428 probable acetyl CoA
acetyltransferase (thiolase) from Streptomyces coelicolor
(404 aa); NP_250427.1|NC_002516 probable acyl-CoA thiolase
from Pseudomonas aeruginosa (401 aa);
NP_106253.1|NC_002678 probable acyl-CoA thiolase from
Mesorhizobium loti (402 aa); NP_248919.1|NC_002516|PcaF
beta-ketoadipyl CoA thiolase PcaF from Pseudomonas
aeruginosa (401 aa); etc. Contains PS00098 Thiolases
acyl-enzyme intermediate signature, PS00737 Thiolases
signature 2 and PS00099 Thiolases active site."
/db_xref="EnsemblGenomes-Gn:Rv0859"
/db_xref="EnsemblGenomes-Tr:CCP43607"
/db_xref="GOA:O53871"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020610"
/db_xref="InterPro:IPR020613"
/db_xref="InterPro:IPR020615"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="PDB:4B3H"
/db_xref="PDB:4B3I"
/db_xref="PDB:4B3J"
/db_xref="UniProtKB/Swiss-Prot:O53871"
/inference="protein motif:PROSITE:PS00098"
/inference="protein motif:PROSITE:PS00737"
/inference="protein motif:PROSITE:PS00099"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43607.1"
/translation="MSEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHP
DLDENLISDVILGCVSPVGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTA
AQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDPATNYDVMFVPQSIGADLIATIE
GFSREDVDAYALRSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGL
AKLKPAFEGLAALGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGK
LQGLTPRARIVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVV
LKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERRNARRALITLCIGG
GMGVATIIERV"
gene 956293..958455
/gene="fadB"
/locus_tag="Rv0860"
CDS 956293..958455
/codon_start=1
/transl_table=11
/gene="fadB"
/locus_tag="Rv0860"
/product="Probable fatty oxidation protein FadB"
/note="Rv0860, (MTV043.53), len: 720 aa. Probable
fadB,fatty oxidation protein, equivalent to
NP_302422.1|NC_002677 putative fatty oxidation complex
alpha subunit from Mycobacterium leprae (714 aa). Also
highly similar to others and various proteins involved in
fatty acid metabolism, e.g. T35429 probable fatty
oxidation protein from Streptomyces coelicolor (733 aa);
NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA
dehydrogenase from Pseudomonas aeruginosa (714 aa);
NP_418895.1|NC_002696 fatty oxidation complex alpha
subunit from Caulobacter crescentus (709 aa);
P40939|ECHA_HUMAN trifunctional enzyme alpha subunit
[includes: long-chain enoyl-CoA hydratase ; long chain
3-hydroxyacyl-CoA dehydrogenase ] from Homo sapiens (763
aa), FASTA scores: opt: 1176, E(): 0, (32.4% identity in
722 aa overlap); P21177|FADB_ECOLI fatty oxidation complex
alpha subunit [includes: enoyl-CoA hydratase;
delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase;
3-hydroxyacyl-CoA dehydrogenase; 3- hydroxybutyryl-CoA
epimerase] from Escherichia coli strain K12 (729 aa),
FASTA scores: opt: 873, E(): 0, (33.6% identity in 693 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0860"
/db_xref="EnsemblGenomes-Tr:CCP43608"
/db_xref="GOA:O53872"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR006108"
/db_xref="InterPro:IPR006176"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:4B3H"
/db_xref="PDB:4B3I"
/db_xref="PDB:4B3J"
/db_xref="UniProtKB/TrEMBL:O53872"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43608.1"
/translation="MPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKAVDR
LVAEKDSITGVVVASAKKTFFAGGDVKTMIQARPEDAGDVFNTVETIKRQLRTLETLG
KPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEVTLGLLPGGGGVTRTVRMF
GIQNAFVSVLAQGTRFKPAKAKEIGLVDELVATVEELVPAAKAWIKEELKANPDGAGV
QPWDKKGYKMPGGTPSSPGLAAILPSFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDF
DTASRIESRYFASLVTGQVAKNMMQAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAG
MMGAGIAYVSAKAGYEVVLKDVSLEAAAKGKGYSEKLEAKALERGRTTQERSDALLAR
ITPTADAADFKGVDFVIEAVFENQELKHKVFGEIEDIVEPNAILGSNTSTLPITGLAT
GVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYTLAIGKTPIVVNDSRG
FFTSRVIGTFVNEALAMLGEGVEPASIEQAGSQAGYPAPPLQLSDELNLELMHKIAVA
TRKGVEDAGGTYQPHPAEAVVEKMIELGRSGRLKGAGFYEYADGKRSGLWPGLRETFK
SGSSQPPLQDMIDRMLFAEALETQKCLDEGVLTSTADANIGSIMGIGFPPWTGGSAQF
IVGYSGPAGTGKAAFVARARELAAAYGDRFLPPESLLS"
gene complement(958523..960151)
/gene="ercc3"
/locus_tag="Rv0861c"
CDS complement(958523..960151)
/codon_start=1
/transl_table=11
/gene="ercc3"
/locus_tag="Rv0861c"
/product="DNA helicase Ercc3"
/note="Rv0861c, (MTV043.54c), len: 542 aa. Ercc3, DNA
helicase (see citation below), equivalent to
NP_302420.1|NC_002677 probable DNA helicase from
Mycobacterium leprae (549 aa). Also highly similar to
others (shorter than several eukaryotic enzymes) e.g.
NP_218820.1|NC_000919|AE001217|AE0 01217_6 putative DNA
repair helicase from Treponema pallidum (606 aa), FASTA
scores: opt: 1275, E(): 0, (47.5% identity in 592 aa
overlap); Q00578|RA25_YEAST DNA repair helicase from
Saccharomyces cerevisiae (843 aa), FASTA scores: opt:
777,E(): 0, (30.4% identity in 605 aa overlap);
P49135|XPB_MOUSE DNA-repair protein complementing XP-B
cells from Mus musculus (Mouse) (783 aa), FASTA scores:
opt: 761, E(): 0, (36.3% identity in 375 aa overlap); etc.
Seems to belong to the helicase family. Alternative
nucleotide at position 958922 (C->a; A410A) has been
observed."
/db_xref="EnsemblGenomes-Gn:Rv0861c"
/db_xref="EnsemblGenomes-Tr:CCP43609"
/db_xref="GOA:O53873"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR006935"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR032438"
/db_xref="InterPro:IPR032830"
/db_xref="UniProtKB/TrEMBL:O53873"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43609.1"
/translation="MQSDKTVLLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPL
ALWNARAAGHDAEQVVDALVSYSRYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLV
SLDRAVLEEVLRNKKIAPMLGARIDDDTVVVHPSERGRVKQLLLKIGWPAEDLAGYVD
GEAHPISLHQEGWQLRDYQRLAADSFWAGGSGVVVLPCGAGKTLVGAAAMAKAGATTL
ILVTNIVAARQWKRELVARTSLTENEIGEFSGERKEIRPVTISTYQMITRRTKGEYRH
LELFDSRDWGLIIYDEVHLLPAPVFRMTADLQSKRRLGLTATLIREDGREGDVFSLIG
PKRYDAPWKDIEAQGWIAPAECVEVRVTMTDSERMMYATAEPEERYRICSTVHTKIAV
VKSILAKHPDEQTLVIGAYLDQLDELGAELGAPVIQGSTRTSEREALFDAFRRGEVAT
LVVSKVANFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRILRPKADGGGAIFYSVVARD
SLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI"
repeat_region complement(960173..960225)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(960226..960278)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(960279..960333)
/note="55 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene complement(960342..962612)
/locus_tag="Rv0862c"
CDS complement(960342..962612)
/codon_start=1
/transl_table=11
/locus_tag="Rv0862c"
/product="Conserved protein"
/note="Rv0862c, (MTV043.55c), len: 756 aa. Conserved
protein, equivalent to NP_302419.1|NC_002677 possible
DNA-binding protein from Mycobacterium leprae (753 aa);
and highly similar (except in C-terminus) to
MLCB57.01|Z99494|T45333 hypothetical protein from
Mycobacterium leprae (>577 aa, truncated), FASTA scores:
opt: 3047, E(): 0, (78.9% identity in 578 aa overlap).
Also similar in part to SCD12A.03c|AB93395.1|AL357524
hypothetical protein from Streptomyces coelicolor (867
aa)."
/db_xref="EnsemblGenomes-Gn:Rv0862c"
/db_xref="EnsemblGenomes-Tr:CCP43610"
/db_xref="GOA:O53874"
/db_xref="InterPro:IPR032830"
/db_xref="UniProtKB/TrEMBL:O53874"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43610.1"
/translation="MTEHTPDIPLGSWLAALPDERLTQLLELRPDLAQPPPGSIAALA
ARAQARQSVKAATDELDFLRLAVFDALLVLQADTAPVPIVRLLAVIGDRAAQADVLGA
LADLKQRALAWGETAVRVATDAGTALPWHPGQVTLEGSSRSGDQLADLIAGLDPAQRD
VLDKLLQGSPVGRTRDAAPGAPSDRPVPRLLAMGLLRRIDAETVILPRHVGQVLRGEQ
PGPMELTAPDPVVSTTTPDDADAAAAGAVIDLLREVDVLLENLGATPVAELRSGGLGV
REFKRLAKATGIDEPRLGLILEIAAAAGLIASGMPDPEPPHSDGPFWAPTVAADRFAT
MSPAERWHLLASAWLDLPGRPALIGTRGPDAKPYGALSDSLFSTAAPLDRRLLLGMLA
ELPAGAGVDASRASATLIWRRPRWARRLQPAPIADLLTEGHALGLVGRGAISTPARAL
LDEALEPATAPAAAVGVMARALPKPIDHFLVQADLTVVVPGPLQRELADDLTTVATVE
SAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDDVARRHGQL
RIGMAASFVRCEDPTLLAQVVAAPEADGLALRALAPTVAVSPAPISEVLVTLRGAGFA
PAAEDSTGAVVDVRTRGARVPTPQRRRPYRPPPRPNSEALKAVVAVLREVTAAPFANV
RVDPAVTMSLLQRAAKDQATLVISYLDAAGVATQRVVAPITLRGGQLVAFDSSSGRLR
DFAIHRITLVVSAHDR"
gene 962599..962880
/locus_tag="Rv0863"
CDS 962599..962880
/codon_start=1
/transl_table=11
/locus_tag="Rv0863"
/product="Conserved hypothetical protein"
/note="Rv0863, (MTV043.56), len: 93 aa. Conserved
hypothetical protein, highly similar to
NP_302418.1|NC_002677 conserved hypothetical protein from
Mycobacterium leprae (74 aa). Also weakly similar in part
to U82598|ECU82598_135 hypothetical protein from
Escherichia coli, FASTA scores: (32.4% identity in 71 aa
overlap); and M74011|YEPYSCOP_8 hypothetical protein from
Yersinia enterocolitica (165 aa), FASTA scores: (38.6
identity in 57 aa overlap). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0863"
/db_xref="EnsemblGenomes-Tr:CCP43611"
/db_xref="UniProtKB/TrEMBL:I6XWF9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43611.1"
/translation="MCSVIADQRRPDQPCGVGGCKTCQNGFVADIAEGKARKTRYVDH
GWPTTDPDDHAVSELVTDRTGALSPFGELTFPVPSDDLPYIHPVTVINR"
gene 962890..963393
/gene="moaC2"
/locus_tag="Rv0864"
CDS 962890..963393
/codon_start=1
/transl_table=11
/gene="moaC2"
/locus_tag="Rv0864"
/product="Probable molybdenum cofactor biosynthesis
protein C 2 MoaC2"
/note="Rv0864, (MTV043.57), len: 167 aa. Probable
moaC2,molybdopterin cofactor biosynthesis protein, highly
similar to others e.g. CAB59676.1|AL132674 molybdenum
cofactor biosynthesis protein from Streptomyces coelicolor
(170 aa); NP_418834.1|NC_002696 molybdenum cofactor
biosynthesis protein C from Caulobacter crescentus (186
aa); Y10817|ANY10817_3|T44852 molybdopterin co-factor
synthesis protein moaC from Arthrobacter nicotinovorans
plasmid pAO1 (169 aa), FASTA scores: opt: 491, E():
2.4e-29, (51.0% identity in 151 aa overlap); etc. Also
highly similar to O05788|MOAC1|Rv3111|MTCY164.21 putative
molybdenum cofactor biosynthesis protein C from
Mycobacterium tuberculosis (170 aa), FASTA scores: opt:
491, E(): 2.4e-29, (54.9% identity in 153 aa overlap); and
O53376|Rv3324c|MOAC3|MTV016.24c putative molybdenum
cofactor biosynthesis protein C3 (177 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0864"
/db_xref="EnsemblGenomes-Tr:CCP43612"
/db_xref="GOA:P9WJR7"
/db_xref="InterPro:IPR002820"
/db_xref="InterPro:IPR023045"
/db_xref="InterPro:IPR036522"
/db_xref="PDB:4FDF"
/db_xref="UniProtKB/Swiss-Prot:P9WJR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43612.1"
/translation="MARASGASDYRSGELSHQDERGAAHMVDITEKATTKRTAVAAGI
LRTSAQVVALISTGGLPKGDALATARVAGIMAAKRTSDLIPLCHQLALTGVDVDFTVG
QLDIEITATVRSTDRTGVEMEALTAVSVAALTLYDMIKAVDPGALIDDIRVLHKEGGR
RGTWTRR"
gene 963390..963872
/gene="mog"
/locus_tag="Rv0865"
CDS 963390..963872
/codon_start=1
/transl_table=11
/gene="mog"
/locus_tag="Rv0865"
/product="Probable molybdopterin biosynthesis Mog protein"
/note="Rv0865, (MTV043.58), len: 160 aa. Probable
mog,molybdopterin biosynthesis MOG protein, highly similar
or similar to other molybdenum cofactor biosynthesis
proteins e.g. CAB59675.1|AL132674 molybdenum cofactor
biosynthesis protein from Streptomyces coelicolor (179
aa); NP_301253.1|NC_002677 putative molybdenum cofactor
biosynthesis protein from Mycobacterium leprae (181 aa);
CAC39235.1|AJ312124 Mog protein from Eubacterium
acidaminophilum (162 aa); P44645|MOG_HAEIN|MOGA|HI0336
molybdopterin biosynthesis MOG protein from Haemophilus
influenzae (197 aa), FASTA scores: opt: 306, E():
9e-13,(39.6% identity in 139 aa overlap); P28694|MOG_ECOLI
molybdopterin biosynthesis MOG protein from Escherichia
coli (195 aa), FASTA scores: opt: 265, E(): 3.6e-10, (34.2
identity in 146 aa overlap); etc. Also highly similar to
Rv0984|MTV044.12|MOAB2 possible
pterin-4-alpha-carbinolamine dehydratase from
Mycobacterium tuberculosis (181 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0865"
/db_xref="EnsemblGenomes-Tr:CCP43613"
/db_xref="InterPro:IPR001453"
/db_xref="InterPro:IPR036425"
/db_xref="UniProtKB/TrEMBL:I6Y8Y8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43613.1"
/translation="MSTRSARIVVVSSRAAAGVYTDDCGPIIAGWLEQHGFSSVQPQV
VADGNPVGEALHDAVNAGVDVIITSGGTGISPTDTTPEHTVAVLDYVIPGLADAIRRS
GLPKVPTSVLSRGVCGVAGRTLIINLPGSPGGVRDGLGVLADVLDHALEQIAGGDHPR
"
gene 963869..964294
/gene="moaE2"
/locus_tag="Rv0866"
CDS 963869..964294
/codon_start=1
/transl_table=11
/gene="moaE2"
/locus_tag="Rv0866"
/product="Probable molybdenum cofactor biosynthesis
protein E2 MoaE2 (molybdopterin converting factor large
subunit) (molybdopterin [MPT] converting factor, subunit
2)"
/note="Rv0866, (MTV043.59), len: 141 aa. Probable
moaE2,molybdopterin converting factor E (molybdopterin
converting factor (subunit 2)), similar to others e.g.
Y10817|ANY10817_4|T44853 molybdopterin biosynthesis
protein E chain from Arthrobacter nicotinovorans plasmid
pAO1 (155 aa), FASTA scores: opt: 460, E(): 3.5e-27, (49.3
identity in 146 aa overlap); CAC01331.1|AL390968 moaE-like
protein from Streptomyces coelicolor (152 aa);
NP_389313.1|NC_000964 molybdopterin converting factor
(subunit 2) from Bacillus subtilis (157 aa); etc. Also
highly similar to Rv3119|MOAE1|Z95150|MTCY164_30 putative
molybdenum cofactor biosynthesis protein E from
Mycobacterium tuberculosis (147 aa), FASTA scores: opt:
321, E(): 5.9e-17, (40.9% identity in 132 aa overlap); and
O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE fusion protein
from Mycobacterium tuberculosis (221 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0866"
/db_xref="EnsemblGenomes-Tr:CCP43614"
/db_xref="GOA:P9WJR1"
/db_xref="InterPro:IPR003448"
/db_xref="InterPro:IPR036563"
/db_xref="UniProtKB/Swiss-Prot:P9WJR1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43614.1"
/translation="MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGG
RGVLRLEYSAHPSAAQVLADLVAEVAEESSGVRAVAASHRIGVLQVGEAALVAAVAAD
HRRAAFGTCAHLVETIKARLPVWKHQFFEDGTDEWVGSV"
gene complement(964312..965535)
/gene="rpfA"
/locus_tag="Rv0867c"
CDS complement(964312..965535)
/codon_start=1
/transl_table=11
/gene="rpfA"
/locus_tag="Rv0867c"
/product="Possible resuscitation-promoting factor RpfA"
/note="Rv0867c, (MTV043.60c), len: 407 aa. Possible
rpfA,resuscitation-promoting factor (see citation below).
N-terminus highly similar to N-terminal part (1-125 aa) of
Z99494|MLCB57_3|NP_302417.1|NC_002677 conserved
hypothetical protein from Mycobacterium leprae (174
aa),FASTA scores: opt: 785, E(): 1.8e-18, (63.0% identity
in 200 aa overlap); and highly similar to C-terminus of
NP_301299.1|NC_002677 conserved hypothetical protein from
Mycobacterium leprae (375 aa); and middle part of
NP_302360.1|NC_002677 conserved hypothetical protein from
Mycobacterium leprae (157 aa). N-terminus also highly
similar in part of three secreted proteins from
Streptomyces coelicolor e.g. CAC09538.1|AL442120 putative
secreted protein (244 aa). Regions highly similar to
CAB76321.1|AL158060 putative membrane protein from
Streptomyces coelicolor (121 aa); and middle part of
CAB09664.1|Z96935 rpf from Micrococcus luteus (220 aa).
Also highly similar in part to four
resuscitation-promoting factors from Mycobacterium
tuberculosis: Rv2450 (172 aa),Rv1009 (362 aa), Rv1884c
(176 aa), and Rv2389c (154 aa). Contains a probable
secretory signal sequence in N-terminus. Predicted
possible vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0867c"
/db_xref="EnsemblGenomes-Tr:CCP43615"
/db_xref="GOA:P9WG31"
/db_xref="InterPro:IPR010618"
/db_xref="InterPro:IPR023346"
/db_xref="UniProtKB/Swiss-Prot:P9WG31"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43615.1"
/translation="MSGRHRKPTTSNVSVAKIAFTGAVLGGGGIAMAAQATAATDGEW
DQVARCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIAVGERV
LATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPAPLAPPPADPAPPV
ELAANDLPAPLGEPLPAAPADPAPPADLAPPAPADVAPPVELAVNDLPAPLGEPLPAA
PADPAPPADLAPPAPADLAPPAPADLAPPAPADLAPPVELAVNDLPAPLGEPLPAAPA
ELAPPADLAPASADLAPPAPADLAPPAPAELAPPAPADLAPPAAVNEQTAPGDQPATA
PGGPVGLATDLELPEPDPQPADAPPPGDVTEAPAETPQVSNIAYTKKLWQAIRAQDVC
GNDALDSLAQPYVIG"
gene complement(965983..966261)
/gene="moaD2"
/locus_tag="Rv0868c"
CDS complement(965983..966261)
/codon_start=1
/transl_table=11
/gene="moaD2"
/locus_tag="Rv0868c"
/product="Probable molybdenum cofactor biosynthesis
protein D 2 MoaD2 (molybdopterin converting factor small
subunit) (molybdopterin [MPT] converting factor, subunit
1)"
/note="Rv0868c, (MTV043.61c), len: 92 aa. Probable
moaD2,molybdenum cofactor biosynthesis protein
(molybdopterin converting factor (subunit 1)), similar to
CAB88494.1|AL353816 putative molybdopterin converting
factor from Streptomyces coelicolor (84 aa); and weakly
similar to others MoaD proteins e.g. Z99111|BSUB0008_103
from Bacillus subtilis (77 aa), FASTA scores: opt: 86,
E(): 2.8, (22.9% identity in 83 aa overlap); etc. Also
some similarity with Rv3112|MOAD1|MTCY164.22 putative
molybdenum cofactor biosynthesis protein D from
Mycobacterium tuberculosis (83 aa), FASTA scores: opt:
113, E(): 0.024,(31.3% identity in 83 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0868c"
/db_xref="EnsemblGenomes-Tr:CCP43616"
/db_xref="InterPro:IPR003749"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR016155"
/db_xref="UniProtKB/TrEMBL:I6XWG2"
/protein_id="CCP43616.1"
/translation="MTQVSDESAGIQVTVRYFAAARAAAGAGSEKVTLRSGATVAELI
DGLSVRDVRLATVLSRCSYLRDGIVVRDDAVALSAGDTIDVLPPFAGG"
gene complement(966265..967347)
/gene="moaA2"
/locus_tag="Rv0869c"
CDS complement(966265..967347)
/codon_start=1
/transl_table=11
/gene="moaA2"
/locus_tag="Rv0869c"
/product="Probable molybdenum cofactor biosynthesis
protein A2 MoaA2"
/note="Rv0869c, (MTV043.62c), len: 360 aa. Probable
moaA2,molybdenum cofactor biosynthesis protein, highly
similar to others e.g. CAB59437.1|AL132644|SCI8_6
molybdenum cofactor biosynthesis protein A from
Streptomyces coelicolor (341 aa), FASTA scores: opt: 1336,
E(): 0, (61.7% identity in 332 aa overlap);
S57490|X78980|ANMOAA_1 molybdopterin cofactor synthesis
protein from Arthrobacter nicotinovorans (fragment) (374
aa), FASTA scores: opt: 1059, E(): 0,(49.9% identity in
369 aa overlap); Q44118|MOAA_ARTNI probable molybdopterin
cofactor synthesis protein A from Arthrobacter
nicotinovorans plasmid pAO1 (355 aa); etc. Also similar to
Rv3109|MTCY164.19|Z95150|MOAA1 putative molybdenum
cofactor biosynthesis protein A from Mycobacterium
tuberculosis (359 aa), FASTA scores: opt: 657, E(): 0,
(36.6% identity in 309 aa overlap). Belongs to the MoaA /
NifB / PqqE family."
/db_xref="EnsemblGenomes-Gn:Rv0869c"
/db_xref="EnsemblGenomes-Tr:CCP43617"
/db_xref="GOA:P9WJS1"
/db_xref="InterPro:IPR000385"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR010505"
/db_xref="InterPro:IPR013483"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/Swiss-Prot:P9WJS1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43617.1"
/translation="MTLTALGMPALRSRTNGIADPRVVPTTGPLVDTFGRVANDLRVS
LTDRCNLRCSYCMPERGLRWLPGEQLLRPDELARLIHIAVTRLGVTSVRFTGGEPLLA
HHLDEVVAATARLRPRPEISLTTNGVGLARRAGALAEAGLDRVNVSLDSIDRAHFAAI
TRRDRLAHVLAGLAAAKAAGLTPVKVNAVLDPTTGREDVVDLLRFCLERGYQLRVIEQ
MPLDAGHSWRRNIALSADDVLAALRPHFRLRPDPAPRGSAPAELWLVDAGPNTPRGRF
GVIASVSHAFCSTCDRTRLTADGQIRSCLFSTEETDLRRLLRGGADDDAIEAAWRAAM
WSKPAGHGINAPDFIQPDRPMSAIGG"
gene complement(967344..967733)
/locus_tag="Rv0870c"
CDS complement(967344..967733)
/codon_start=1
/transl_table=11
/locus_tag="Rv0870c"
/product="Possible conserved integral membrane protein"
/note="Rv0870c, (MTV043.63c), len: 129 aa. Possible
conserved integral membrane protein, highly similar to
other membrane proteins: putative secreted proteins or
hypothetical proteins e.g. CAC08263.1| AL392146 putative
integral membrane protein from Streptomyces coelicolor
(138 aa); NP_233433.1|NC_002506 conserved hypothetical
protein from Vibrio cholerae (143 aa);
NP_455572.1|NC_003198 putative membrane protein from
Salmonella enterica subsp. enterica serovar Typhi (148
aa); P37065|YCCF_ECOLI hypothetical 16.3 kDa protein from
Escherichia coli (148 aa), FASTA scores: opt: 183, E():
1.9e-06, (36.6% identity in 134 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0870c"
/db_xref="EnsemblGenomes-Tr:CCP43618"
/db_xref="GOA:I6Y8Z3"
/db_xref="InterPro:IPR005185"
/db_xref="InterPro:IPR031308"
/db_xref="UniProtKB/TrEMBL:I6Y8Z3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43618.1"
/translation="MRLILNVIWLVFGGLWLALGYLLASLVCFLLIITIPFGFAALRI
ASYALWPFGRTIVEKPTAGTGALIGNVIWVLLFGIWLALGHLVSAAAMAVTIIGIPLA
LANLKLIPVSLVPLGKDIVGVNSQVPT"
gene 967898..968305
/gene="cspB"
/locus_tag="Rv0871"
CDS 967898..968305
/codon_start=1
/transl_table=11
/gene="cspB"
/locus_tag="Rv0871"
/product="Probable cold shock-like protein B CspB"
/note="Rv0871, (MTV043.64), len: 135 aa. Probable
cspB,cold shock-like protein B, equivalent to
Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from
Mycobacterium leprae (136 aa), FASTA scores: opt: 787,
E(): 0, (86.0% identity in 136 aa overlap). Also highly
similar (but often longer than) to others e.g.
CAB93399.1|AL357524 cold shock protein B from Streptomyces
coelicolor (127 aa); Q45099|CSPD_BACCE cold shock-like
protein CSPD from Bacillus cereus (66 aa); Y101
81|LLCSPB_1 cold shock protein from Lactococcus lactis (66
aa), FASTA scores: opt: 220, E(): 2.5e-07, (48.3% identity
in 60 aa overlap); etc. Seems to belong to the cold-shock
domain (CSD) family."
/db_xref="EnsemblGenomes-Gn:Rv0871"
/db_xref="EnsemblGenomes-Tr:CCP43619"
/db_xref="GOA:I6WZM9"
/db_xref="InterPro:IPR002059"
/db_xref="InterPro:IPR011129"
/db_xref="InterPro:IPR012340"
/db_xref="UniProtKB/TrEMBL:I6WZM9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43619.1"
/translation="MPTGKVKWYDPDKGFGFLSQEGGEDVYVRSSALPTGVEALKAGQ
RVEFGIASGRRGPQALSLRLIEPPPSLSRPRREPAAEHKHSPDELHGMVEDMITLLES
TVQPELRKGRYPDRKTARRVAEVVRAVAREFES"
gene complement(968424..970244)
/gene="PE_PGRS15"
/locus_tag="Rv0872c"
CDS complement(968424..970244)
/codon_start=1
/transl_table=11
/gene="PE_PGRS15"
/locus_tag="Rv0872c"
/product="PE-PGRS family protein PE_PGRS15"
/note="Rv0872c, (MTV043.65c), len: 606 aa.
PE_PGRS15,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002),similar to many e.g. MTCY24A1.04c|Z95207 (615
aa), FASTA scores: opt: 2636, E(): 0, (64.6% identity in
619 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0872c"
/db_xref="EnsemblGenomes-Tr:CCP43620"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FV3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43620.1"
/translation="MSYVLATPEMVAAAANNLAQIGSTLSAANAAALAPTTGVLAAGA
DEVSAAVASLFSGHAQAYQTLGTQAAAFHERFIQALSTAAGAYGSAEAANASPLQQAL
NVINAPTQTLLGRPLIGNGTNGAPGTGQAGGPGGLLYGNGGNGGSGGVGQAGGAGGSA
GLIGIGGTGGAGGAGAVGGVGGNGGWLYGNGGAGGLGGTGVAGVNGGMGAAGGAGGNA
YLFGSGGAGGQGGMGAAGADGVNPTPTGTADAGSTGTDQTLGGNAIGGNGGPGDAGDA
MTSGGAGGSGGNAVSTVNGDAVGGEGGKGGEGAYGGAGGAGGSAASIGNAAIGGNGGA
GGNAQAPGGVGGAGGEGGDAQVGTNSPSNAEAGNGGSGGNGFDSFASGGTGGAGGTGG
AGGRGGLLIGDGGAGGAGGVGGTGGSGAPGGGGGAGGDGGAANTDSAGSSRKAFGGDG
GVGGDGASALGTGGEGGIGGQGGNGGAGGLLIGNGGAGGVGGTAGAGGTGGSGGAGGA
GGAGGGGTNSGPGAAFGGNGNTGGNGGNGGAPGALGGKGGSGGLIGRAGSDGGVGAGG
AGGAGGAGGTGGEGGTGGDGKTTDGNPGMGGSPGSAGQPG"
gene 970505..972457
/gene="fadE10"
/locus_tag="Rv0873"
CDS 970505..972457
/codon_start=1
/transl_table=11
/gene="fadE10"
/locus_tag="Rv0873"
/product="Probable acyl-CoA dehydrogenase FadE10"
/note="Rv0873, (MTV043.66-MTCY31.01), len: 650 aa.
Probable fadE10, acyl-CoA dehydrogenase, highly similar to
many e.g. CAB91129.1|AL355913 putative acyl CoA
dehydrogenase from Streptomyces coelicolor (658 aa);
P50544|ACDV_MOUSE acyl-CoA dehydrogenase from Mus musculus
(656 aa); D30647|RATVLCAD_1 very-long-chain Acyl-CoA
dehydrogenase from Rattus norvegicus (655 aa), FASTA
scores: opt: 675,E(): 0, (33.9% identity in 380 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0873"
/db_xref="EnsemblGenomes-Tr:CCP43621"
/db_xref="GOA:P9WQF7"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/Swiss-Prot:P9WQF7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43621.1"
/translation="MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIH
PFPKPSDAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKIPS
EYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTAEQKRRFLPRC
AAGAISAFLLTEPDVGSDPARMASTATPIDDGQAYELEGVKLWTTNGVVADLLVVMAR
VPRSEGHRGGISAFVVEADSPGITVERRNKFMGLRGIENGVTRLHRVRVPKDNLIGRE
GDGLKIALTTLNAGRLSLPAIATGVAKQALKIAREWSVERVQWGKPVGQHEAVASKIS
FIAATNYALDAVVELSSQMADEGRNDIRIEAALAKLWSSEMACLVGDELLQIRGGRGY
ETAESLAARGERAVPVEQMVRDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDLANP
KADLRQKAAAAAGASGFYAKWLPKLVFGEGQLPTTYREFGALATHLRFVERSSRKLAR
NTFYGMARWQASLEKKQGFLGRIVDIGAELFAISAACVRAEAQRTADPVEGEQAYELA
EAFCQQATLRVEALFDALWSNTDSIDVRLANDVLEGRYTWLEQGILDQSEGTGPWIAS
WEPGPSTEANLARRFLTVSPSSEAKL"
gene complement(972546..973706)
/locus_tag="Rv0874c"
CDS complement(972546..973706)
/codon_start=1
/transl_table=11
/locus_tag="Rv0874c"
/product="Conserved hypothetical protein"
/note="Rv0874c, (MTCY31.02c), len: 386 aa. Conserved
hypothetical protein, highly similar in part to SPU62616_1
hypothetical protein from Synechococcus sp. (280 aa),
FASTA scores: E(): 6.3e-26, (35.2% identity in 264 aa
overlap); SYCSLLLH_102 from Synechocystis sp. (447 aa),
FASTA scores: E(): 1.1e-18, (29.5% identity in 400 aa
overlap). Also highly similar to Rv0628c|MTCY20H10_9 from
Mycobacterium tuberculosis (383 aa), FASTA scores: E():0,
(81.5% identity in 383 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0874c"
/db_xref="EnsemblGenomes-Tr:CCP43622"
/db_xref="GOA:P9WKR9"
/db_xref="InterPro:IPR013702"
/db_xref="InterPro:IPR016741"
/db_xref="InterPro:IPR019494"
/db_xref="UniProtKB/Swiss-Prot:P9WKR9"
/protein_id="CCP43622.1"
/translation="MRIGVGVCTTPDARQAAVEAAGQARDELAGEAPSLAVLLGSRAH
TDRAADVLSAVLQMIDPPALVGCIAQAIVAGRHEIEDEPAVVVWLASGLAAETFQLDF
VRTGSGALITGYRFDRTARDLHLLLPDPYTFPSNLLIEHPNTDLPGTAVVGGVVSGGR
RRGDTRLFRDHDVLTSGVVGVRLPGMRGVPVVSQGCRPIGYPYIVTGADGILITELGG
RPPLQRLREIVEGLSPDERALVSHGLQIGIVVDEHLAAPGQGDFVIRGLLGADPSTGS
IEIDEVVQVGATMQFQVRDAAGADKDLRLTVERAAARLPGRAAGALLFTCNGRGRRMF
GVADHDASTIEELLGGIPLAGFFAAGEIGPIAGRNALHGFTASMALFVDDME"
gene complement(973806..974294)
/locus_tag="Rv0875c"
CDS complement(973806..974294)
/codon_start=1
/transl_table=11
/locus_tag="Rv0875c"
/product="Possible conserved exported protein"
/note="Rv0875c, (MTCY31.03c), len: 162 aa. Possible
conserved exported protein, equivalent to MLCB57_11|O33056
possible exported protein from Mycobacterium leprae (162
aa), FASTA scores: opt: 789, E(): 0, (71.4% identity in
161 aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004).
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0875c"
/db_xref="EnsemblGenomes-Tr:CCP43623"
/db_xref="GOA:P9WKR7"
/db_xref="InterPro:IPR024495"
/db_xref="UniProtKB/Swiss-Prot:P9WKR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43623.1"
/translation="MKRGVATLPVILVILLSVAAGAGAWLLVRGHGPQQPEISAYSHG
HLTRVGPYLYCNVVDLDDCQTPQAQGELPVSERYPVQLSVPEVISRAPWRLLQVYQDP
ANTTSTLFRPDTRLAVTIPTVDPQRGRLTGIVVQLLTLVVDHSGELRDVPHAEWSVRL
IF"
gene complement(974291..975937)
/locus_tag="Rv0876c"
CDS complement(974291..975937)
/codon_start=1
/transl_table=11
/locus_tag="Rv0876c"
/product="Possible conserved transmembrane protein"
/note="Rv0876c, (MTCY31.04c), len: 548 aa. Possible
conserved transmembrane protein, equivalent to
MLCB57_12|O33057 possible membrane protein from
Mycobacterium leprae (579 aa), FASTA scores: opt:
2850,E(): 0, (81.0% identity in 568 aa overlap). Also
highly similar (except in N-terminus) to
CAB93403.1|AL357524 putative integral membrane protein
from Streptomyces coelicolor (463 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0876c"
/db_xref="EnsemblGenomes-Tr:CCP43624"
/db_xref="GOA:P9WKR5"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WKR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43624.1"
/translation="MAPTPGRRTRNGSVNGHPGMANYPPDDANYRRSRRPPPMPSANR
YLPPLGEQPEPERSRVPPRTTRAGERITVTRAAAMRSREMGSRMYLLVHRAATADGAD
KSGLTALTWPVMANFAVDSAMAVALANTLFFAAASGESKSRVALYLLITIAPFAVIAP
LIGPALDRLQHGRRVALALSFGLRTALAVVLIMNYDGATGSFPSWVLYPCALAMMVFS
KSFSVLRSAVTPRVMPPTIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVCTHLFQLP
GALFVVVAITIAGASLSMRIPRWVEVTSGEVPATLSYHRDRGRLRRRWPEEVKNLGGT
LRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAKAHEANGWVQLGMLGLIGAAAAVG
NFAGNFTSARLQLGRPAVLVVRCTVLVTVLAIAAAVAGSLAATAIATLITAGSSAIAK
ASLDASLQHDLPEESRASGFGRSESTLQLAWVLGGAVGVLVYTELWVGFTAVSALLIL
GLAQTIVSFRGDSLIPGLGGNRPVMAEQETTRRGAAVAPQ"
gene 976075..976863
/locus_tag="Rv0877"
CDS 976075..976863
/codon_start=1
/transl_table=11
/locus_tag="Rv0877"
/product="Conserved hypothetical protein"
/note="Rv0877, (MTCY31.05), len: 262 aa. Conserved
hypothetical protein, equivalent to MLCB57_13|O33058
conserved hypothetical protein from Mycobacterium leprae
(269 aa), FASTA scores: E(): 0, (80.5% identity in 257 aa
overlap). Also highly similar (except in C-terminus) to
SCD12A.13|CAB93404.1|AL357524 hypothetical protein from
Streptomyces coelicolor (308 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0877"
/db_xref="EnsemblGenomes-Tr:CCP43625"
/db_xref="InterPro:IPR021391"
/db_xref="UniProtKB/Swiss-Prot:P9WKR3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43625.1"
/translation="MTGPTEESAVATVADWPEGLAAVLRGAADQARAAVVEFSGPEAV
GDYLGVSYEDGNAATHRFIAHLPGYQGWQWAVVVASYSGADHATISEVVLVPGPTALL
APDWVPWEQRVRPGDLSPGDLLAPAKDDPRLVPGYTASGDAQVDETAAEIGLGRRWVM
SAWGRAQSAQRWHDGDYGPGSAMARSTKRVCRDCGFFLPLAGSLGAMFGVCGNELSAD
GHVVDRQYGCGAHSDTTAPAGGSTPIYEPYDDGVLDIIEKPAES"
gene complement(976872..978203)
/gene="PPE13"
/locus_tag="Rv0878c"
CDS complement(976872..978203)
/codon_start=1
/transl_table=11
/gene="PPE13"
/locus_tag="Rv0878c"
/product="PPE family protein PPE13"
/note="Rv0878c, (MTCY31.06c), len: 443 aa. PPE13, Member
of the Mycobacterium tuberculosis PPE family, highly
similar to many e.g. P4261|YHS6_MYCTU (517 aa), FASTA
scores: opt: 1044, E(): 0, (47.4% identity in 397 aa
overlap); MTV014_3,MTCI65_2, MTCY98_24, MTCY3C7_23,
MTCY48_17, MTV004_5,MTV004_3, etc. Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0878c"
/db_xref="EnsemblGenomes-Tr:CCP43626"
/db_xref="GOA:P9WI35"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI35"
/protein_id="CCP43626.1"
/translation="MNFMVLPPEVNSARIYAGAGPAPMLAAAVAWDGLAAELGMAAAS
FSLLISGLTAGPGSAWQGPAAAAMAAAAAPYLSWLNAATARAEGAAAGAKAAAAVYEA
ARAATAHPALVAANRNQLLSLVLSNLFGQNLPAIAATEASYEQLWAQDVAAMVGYHGG
ASTVASQLTPWQQLLSVLPPVVTAAPAGAVGVPAALAIPALGVENIGVGNFLGIGNIG
NNNVGSGNTGDYNFGIGNIGNANLGNGNIGNANLGSGNAGFFNFGNGNDGNTNFGSGN
AGFLNIGSGNEGSGNLGFGNAGDDNTGWGNSGDTNTGGFNSGDLNTGIGSPVTQGVAN
SGFGNTGTGHSGFFNSGNSGSGFQNLGNGSSGFGNASDTSSGFQNAGTALTRASSTWA
DSPRAWPIRAPSRLQVWRTRATTARECSIRVIISRVSSTGAPPQKKVGNSG"
gene complement(978481..978756)
/locus_tag="Rv0879c"
CDS complement(978481..978756)
/codon_start=1
/transl_table=11
/locus_tag="Rv0879c"
/product="Possible conserved transmembrane protein"
/note="Rv0879c, (MTCY31.07c), len: 91 aa. Possible
conserved transmembrane protein, C-terminus highly similar
to C-terminal part of MLCB57_14|O33059 conserved
hypothetical protein from Mycobacterium leprae (91
aa),FASTA scores: E(): 1.2e-25, (76.9% identity in 91 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0879c"
/db_xref="EnsemblGenomes-Tr:CCP43627"
/db_xref="GOA:P9WKR1"
/db_xref="InterPro:IPR019681"
/db_xref="UniProtKB/Swiss-Prot:P9WKR1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43627.1"
/translation="MSVENSQIREPPPLPPVLLEVWPVIAVGALAWLVAAVAAFVVPG
LASWRPVTVAGLATGLLGTTIFVWQLAAARRGARGAQAGLETYLDPK"
gene 978934..979365
/locus_tag="Rv0880"
CDS 978934..979365
/codon_start=1
/transl_table=11
/locus_tag="Rv0880"
/product="Possible transcriptional regulatory protein
(possibly MarR-family)"
/note="Rv0880, (MTCY31.08), len: 143 aa. Possible
transcriptional regulator, MarR family, equivalent to
MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family
protein from Mycobacterium leprae (143 aa), FASTA scores:
opt: 818, E(): 0, (89.5% identity in 143 aa overlap). Also
similar to many others e.g. CAB93410.1|AL357524 putative
marR-family protein from Streptomyces coelicolor (145 aa);
NP_251757.1|NC_002516 probable transcriptional regulator
from Pseudomonas aeruginosa (147 aa); etc. Also similar to
Rv2327 from Mycobacterium tuberculosis (163 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0880"
/db_xref="EnsemblGenomes-Tr:CCP43628"
/db_xref="GOA:P9WMF1"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR023187"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:4YIF"
/db_xref="UniProtKB/Swiss-Prot:P9WMF1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43628.1"
/translation="MLDSDARLASDLSLAVMRLSRQLRFRNPSSPVSLSQLSALTTLA
NEGAMTPGALAIRERVRPPSMTRVIASLADMGFVDRAPHPIDGRQVLVSVSESGAELV
KAARRARQEWLAERLATLNRSERDILRSAADLMLALVDESP"
gene 979362..980228
/locus_tag="Rv0881"
CDS 979362..980228
/codon_start=1
/transl_table=11
/locus_tag="Rv0881"
/product="Possible rRNA methyltransferase (rRNA
methylase)"
/note="Rv0881, (MTCY31.09), len: 288 aa. Possible rRNA
methyltransferase, highly similar to others and
hypothetical proteins e.g. CAB76071.1|AL157953 putative
rRNA methylase from Streptomyces coelicolor (272 aa);
NP_421117.1|NC_002696 spoU rRNA methylase family protein
from Caulobacter crescentus (268 aa); D90913_93|P74261
rRNA methylase from Synechocystis sp. (274 aa), FASTA
scores: E(): 1.1e-13, (26.3% identity in 278 aa overlap);
P18644|TSNR_STRCN rRNA methyltransferase from Streptomyces
cyaneus (Streptomyces curacoi) (269 aa), FASTA scores:
E(): 3.7e-08, (23.9% identity in 268 aa overlap); etc.
Equivalent to AAK45146.1 from Mycobacterium tuberculosis
strain CDC1551 (242 aa) but longer 46 aa."
/db_xref="EnsemblGenomes-Gn:Rv0881"
/db_xref="EnsemblGenomes-Tr:CCP43629"
/db_xref="GOA:P9WFY3"
/db_xref="InterPro:IPR001537"
/db_xref="InterPro:IPR029026"
/db_xref="InterPro:IPR029028"
/db_xref="InterPro:IPR029064"
/db_xref="UniProtKB/Swiss-Prot:P9WFY3"
/protein_id="CCP43629.1"
/translation="MTEGRCAQHPDGLDVQDVCDPDDPRLDDFRDLNSIDRRPDLPTG
KALVIAEGVLVVQRMLASRFTPLALFGTDRRLAELKDDLAGVGAPYYRASADVMARVI
GFHLNRGVLAAAGRVPEPSVAQVVAGARTVAVLEGVNDHENLGSIFRNAAGLSVDAVV
FGTGCADPLYRRAVRVSMGHALLVPYARAADWPTELMTLKESGFRLLAMTPHGNACKL
PEAIAAVSHERIALLVGAEGPGLTAAALRISDVRVRIPMSRGTDSLNVATAAALAFYE
RTRSGHHIGPGT"
gene 980225..980509
/locus_tag="Rv0882"
CDS 980225..980509
/codon_start=1
/transl_table=11
/locus_tag="Rv0882"
/product="Probable transmembrane protein"
/note="Rv0882, (MTCY31.10), len: 94 aa. Probable
transmembrane protein."
/db_xref="EnsemblGenomes-Gn:Rv0882"
/db_xref="EnsemblGenomes-Tr:CCP43630"
/db_xref="GOA:P9WKQ9"
/db_xref="InterPro:IPR024244"
/db_xref="UniProtKB/Swiss-Prot:P9WKQ9"
/protein_id="CCP43630.1"
/translation="MNDQRDQAVPWATGLAVAGFVAAVIAVAVVVLSLGLIRVHPLLA
VGLNIVAVSGLAPTLWGWRRTPVLRWFVLGAAVGVAGAWLALLALTLGDG"
gene complement(980506..981267)
/locus_tag="Rv0883c"
CDS complement(980506..981267)
/codon_start=1
/transl_table=11
/locus_tag="Rv0883c"
/product="Conserved hypothetical protein"
/note="Rv0883c, (MTCY31.11c), len: 253 aa. Conserved
hypothetical protein, equivalent to O3306|MLCB57_16
conserved hypothetical protein from Mycobacterium leprae
(251 aa), FASTA scores: E(): 0, (79.4% identity in 253 aa
overlap). Also highly similar to N_terminus of
AL009204|SC9B10_22 hypothetical protein from Streptomyces
coelicolor (352 aa), FASTA scores: E(): 6.1e-20, (35.0%
identity in 246 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0883c"
/db_xref="EnsemblGenomes-Tr:CCP43631"
/db_xref="InterPro:IPR021421"
/db_xref="UniProtKB/Swiss-Prot:P9WKQ7"
/protein_id="CCP43631.1"
/translation="MRELKVVGLDADGKNIICQGAIPSEQFKLPVDDRLRAALRDDSV
QPEQAQLDIEVTNVLSPKEIQARIRAGASVEQVAAASGSDIARIRRFAHPVLLERSRA
AELATAAHPVLADGPAVLTMQETVAAALVARGLNPDSLTWDAWRNEDSRWTVQLAWKA
GRSDNLAHFRFTPGAHGGTATAIDDTAHELINPTFNRPLRPLAPVAHLDFDEPEPAQP
TLTVPSAQPVSNRRGKPAIPAWEDVLLGVRSGGRR"
gene complement(981424..982554)
/gene="serC"
/locus_tag="Rv0884c"
CDS complement(981424..982554)
/codon_start=1
/transl_table=11
/gene="serC"
/locus_tag="Rv0884c"
/product="Possible phosphoserine aminotransferase SerC
(PSAT)"
/note="Rv0884c, (MTCY31.12c), len: 376 aa. Possible
serC,phosphoserine aminotransferase, equivalent to
MLCB57_17 putative phosphoserine aminotransferase from
Mycobacterium leprae (376 aa), FASTA scores: E(): 0, (87.5
identity in 376 aa overlap). Also highly similar to
CAC08322.1|AL392149 putative aminotransferase from
Streptomyces coelicolor (363 aa); and similar to other
phosphoserine aminotransferases e.g. NP_386837.1|NC_003047
putative phosphoserine aminotransferase protein from
Sinorhizobium meliloti (392 aa); P52878|SERC_METBA
phosphoserine aminotransferase from Methanosarcina barkeri
(370 aa); P10658|SERC_RABIT|RABEPIP_1 phosphoserine
aminotransferase from Rabbit (370 aa), FASTA scores: opt:
271, E(): 3.5e-11,(24.5% identity in 368 aa overlap); etc.
Belongs to class-V of pyridoxal-phosphate-dependent
aminotransferases. Cofactor: pyridoxal phosphate."
/db_xref="EnsemblGenomes-Gn:Rv0884c"
/db_xref="EnsemblGenomes-Tr:CCP43632"
/db_xref="GOA:P9WQ73"
/db_xref="InterPro:IPR000192"
/db_xref="InterPro:IPR006272"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR022278"
/db_xref="PDB:2FYF"
/db_xref="PDB:3VOM"
/db_xref="UniProtKB/Swiss-Prot:P9WQ73"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43632.1"
/translation="MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAAL
FGTSHRQAPVKNLVGRVRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRSLH
LTYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAV
AVRRPEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAAL
SRIEAIAATGRWVPDFLSLPIAVENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDW
AVKRTADSSQRLYSWAQERPYTTPFVTDPGLRSQVVGTIDFVDDVDAGTVAKILRANG
IVDTEPYRKLGRNQLRVAMFPAVEPDDVSALTECVDWVVERL"
gene 982762..983784
/locus_tag="Rv0885"
CDS 982762..983784
/codon_start=1
/transl_table=11
/locus_tag="Rv0885"
/product="Conserved hypothetical protein"
/note="Rv0885, (MTCY31.13), len: 340 aa. Conserved
hypothetical protein, equivalent to O33063|MLCB57_18
possible transmembrane protein from Mycobacterium leprae
(341 aa), FASTA score: (83.9% identity in 341 aa overlap).
Also similar except in C-terminus to T35630 probable
membrane protein from Streptomyces coelicolor (312 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0885"
/db_xref="EnsemblGenomes-Tr:CCP43633"
/db_xref="GOA:P9WKQ5"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR025859"
/db_xref="UniProtKB/Swiss-Prot:P9WKQ5"
/protein_id="CCP43633.1"
/translation="MDRTRIVRRWRRNMDVADDAEYVEMLATLSEGSVRRNFNPYTDI
DWESPEFAVTDNDPRWILPATDPLGRHPWYQAQSRERQIEIGMWRQANVAKVGLHFES
ILIRGLMNYTFWMPNGSPEYRYCLHESVEECNHTMMFQEMVNRVGADVPGLPRRLRWV
SPLVPLVAGPLPVAFFIGVLAGEEPIDHTQKNVLREGKSLHPIMERVMSIHVAEEARH
ISFAHEYLRKRLPRLTRMQRFWISLYFPLTMRSLCNAIVVPPKAFWEEFDIPREVKKE
LFFGSPESRKWLCDMFADARMLAHDTGLMNPIARLVWRLCKIDGKPSRYRSEPQRQHL
AAAPAA"
gene 983803..985530
/gene="fprB"
/locus_tag="Rv0886"
CDS 983803..985530
/codon_start=1
/transl_table=11
/gene="fprB"
/locus_tag="Rv0886"
/product="Probable NADPH:adrenodoxin oxidoreductase FprB
(adrenodoxin reductase) (AR) (ferredoxin-NADP(+)
reductase)"
/note="Rv0886, (MTCY31.14), len: 575 aa. Probable
fprB,ferredoxin/ferredoxin-NADP(+) reductase
(NADPH:adrenodoxin oxidoreductase), equivalent to
O3306|MLCB57_19 ferredoxin/ferredoxin--NADP reductase from
Mycobacterium leprae (555 aa), FASTA scores: E(): 0, (76.6
identity in 560 aa overlap). Also highly similar or
similar to others e.g. NP_294219.1|NC_001263 putative
ferredoxin/ferredoxin--NADP reductase from Deinococcus
radiodurans (479 aa) (N-terminus shorter);
P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from
homo sapiens (497 aa), FASTA scores: opt: 624, E():
3e-30,(39.7% identity in 484 aa overlap);
P08165|ADRO_BOVIN NADPH:adrenodoxin oxidoreductase from
Bos taurus (492 aa); etc. Also similar to others from
Mycobacterium tuberculosis e.g. Rv3106, Rv3858c, etc.
Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding
region signature."
/db_xref="EnsemblGenomes-Gn:Rv0886"
/db_xref="EnsemblGenomes-Tr:CCP43634"
/db_xref="GOA:P9WJI1"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR017900"
/db_xref="InterPro:IPR021163"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WJI1"
/inference="protein motif:PROSITE:PS00198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43634.1"
/translation="MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPV
ACVDCGACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPVTP
AAEVRVRRQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPYGLVRSGVAPDH
QNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAHHHAVLYAVGAPDDRRLTID
GMGLPGTGTATELVAWLNGHPDFNDLPVDLSHERVVIIGNGNVALDVARVLAADPHEL
AATDIADHALSALRNSAVREVVVAARRGPAHSAFTLPELIGLTAGADVVLDPGDHQRV
LDDLAIVADPLTRNKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQRRAGGVQ
FSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVIDPGTGEPVPG
AYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDPVATPTALDQLVQARQPQ
AIGCAGWRAIDAAEIARGSADGRVRNKFTDVAEMLAAATSAPKEPLRRRVLARLRDLG
QPIVLTVPL"
gene complement(985513..985971)
/locus_tag="Rv0887c"
CDS complement(985513..985971)
/codon_start=1
/transl_table=11
/locus_tag="Rv0887c"
/product="Conserved hypothetical protein"
/note="Rv0887c, (MTCY31.15c), len: 152 aa. Conserved
hypothetical protein, highly similar to others e.g.
NP_436346.1|NC_003037 Hypothetical protein from
Sinorhizobium meliloti (149 aa); AL132644|SCI8_26
hypothetical protein from Streptomyces coelicolor (194
aa),FASTA scores: opt: 220, E(): 1.5e-07, (33.6% identity
in 131 aa overlap); etc. Also shows weak similarity with
transposases and related proteins."
/db_xref="EnsemblGenomes-Gn:Rv0887c"
/db_xref="EnsemblGenomes-Tr:CCP43635"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="InterPro:IPR041581"
/db_xref="UniProtKB/Swiss-Prot:P9WKQ3"
/protein_id="CCP43635.1"
/translation="MAINVEPALSPHLVVDDAASAIDFYVKAFDAVELGRVPGPDGKL
IHAALRINGFTVMLNDDVPQMCGGKSMTPTSLGGTPVTIHLTVTDVDAKFQRALNAGA
TVVTALEDQLWGDRYGVVADPFGHHWSLGQPVREVNMDEIQAAMSSQGDG"
gene 987233..988705
/locus_tag="Rv0888"
CDS 987233..988705
/codon_start=1
/transl_table=11
/locus_tag="Rv0888"
/product="Probable exported protein"
/note="Rv0888, (MTCY31.16), len: 490 aa. Probable exported
protein. Equivalent to AAK45157.1 from Mycobacterium
tuberculosis strain CDC1551 (507 aa) but shorter 17 aa.
Contains possible N-terminal signal sequence. Predicted to
be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0888"
/db_xref="EnsemblGenomes-Tr:CCP43636"
/db_xref="GOA:P9WKQ1"
/db_xref="InterPro:IPR005135"
/db_xref="InterPro:IPR036691"
/db_xref="UniProtKB/Swiss-Prot:P9WKQ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43636.1"
/translation="MDYAKRIGQVGALAVVLGVGAAVTTHAIGSAAPTDPSSSSTDSP
VDACSPLGGSASSLAAIPGASVPQVGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPII
ENRTPVANPQQVSVPEGGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQR
TASFIYTADPGFVGTDTFSVNVSDDTSLHVHGLAGYLGPFHGHDDVATVTVFVGNTPT
DTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAYYVANVQEDFAYHQFLI
KKSKMPSQTPPEPPTLLWPIGVPFSDGLNTLSEFKVQRLDRQTWYECTSDNCLTLKGF
TYSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVTGDFNARY
SDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKIFYRSGQGVTL
QAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR"
gene complement(988740..989861)
/gene="citA"
/gene_synonym="gltA"
/locus_tag="Rv0889c"
CDS complement(988740..989861)
/codon_start=1
/transl_table=11
/gene="citA"
/gene_synonym="gltA"
/locus_tag="Rv0889c"
/product="Probable citrate synthase II CitA"
/note="Rv0889c, (MTCY31.17c), len: 373 aa. Probable citA
(alternate gene name: gltA), citrate synthase 2, highly
similar to others e.g. CAB95899.1|AL359988 putative
citrate synthase from Streptomyces coelicolor (387 aa);
P39119|CISY_BACSU citrate synthase II from Bacillus
subtilis (366 aa), FASTA scores: opt: 586, E():
5.8e-30,(33.8% identity in 367 aa overlap); etc. Also
similar to Rv0896|MTCY31.24 from Mycobacterium
tuberculosis (29.2% identity in 274 aa overlap) and
Rv1131. Contains PS00480 Citrate synthase signature.
Belongs to the citrate synthase family."
/db_xref="EnsemblGenomes-Gn:Rv0889c"
/db_xref="EnsemblGenomes-Tr:CCP43637"
/db_xref="GOA:P9WPD3"
/db_xref="InterPro:IPR002020"
/db_xref="InterPro:IPR016142"
/db_xref="InterPro:IPR016143"
/db_xref="InterPro:IPR019810"
/db_xref="InterPro:IPR036969"
/db_xref="UniProtKB/Swiss-Prot:P9WPD3"
/inference="protein motif:PROSITE:PS00480"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43637.1"
/translation="MTVVPENFVPGLDGVVAFTTEIAEPDKDGGALRYRGVDIEDLVS
QRVTFGDVWALLVDGNFGSGLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLLD
IDDATARQQLARASVMALSYVAQSARGIYQPAVPQRIIDECSTVTARFMTRWQGEPDP
RHIEAIDAYWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARV
LPMLDEVERAGDARSVVKGILDRGEKLMGFGHRVYRAEDPRARVLRAAAERLGAPRYE
VAVAVEQAALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCA
HILEQKRLGKLVRPSAIYVGPGPRSPESVDGWERVLTTA"
gene complement(989948..992596)
/locus_tag="Rv0890c"
CDS complement(989948..992596)
/codon_start=1
/transl_table=11
/locus_tag="Rv0890c"
/product="Probable transcriptional regulatory protein
(probably LuxR-family)"
/note="Rv0890c, (MTCY31.18c), len: 882 aa. Probable
transcriptional regulatory protein, LuxR family, highly
similar (but shorter 238 aa in N-terminus) to
NP_302202.1|NC_002677 possible transcriptional regulator
from Mycobacterium leprae (1106 aa). Also highly similar
(generally in part) to others e.g. T50568 probable
multi-domain regulatory protein from Streptomyces
coelicolor (1334 aa); P10957|NARL_ECOLI nitrate/nitrite
response regulator protein from Escherichia coli (216
aa),FASTA scores: opt: 193, E(): 6e-06, (37.4% identity in
99 aa overlap); etc. Also highly similar to others from
Mycobacterium tuberculosis e.g. MTCY02B10_22,
MTV008_44,MTV036_21, and MTCY31_24. Contains PS00017
ATP/GTP-binding site motif A (P-loop), PS00622 Bacterial
regulatory proteins, luxR family signature, and probable
helix-turn helix motif from aa 836 to 857 (Score 1559,
+4.50 SD). Belongs to the LuxR/UhpA family of
transcriptional regulators. Alternative nucleotide at
position 990001 (G->C; P866A) has been observed."
/db_xref="EnsemblGenomes-Gn:Rv0890c"
/db_xref="EnsemblGenomes-Tr:CCP43638"
/db_xref="GOA:P9WMG1"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WMG1"
/inference="protein motif:PROSITE:PS00622"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43638.1"
/translation="MRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLA
PITESGIVAATAARAVGLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAALVV
ELLGACPELTILATSREPIGMAGEITWRVPSMSITDEAVELFADRASRVQPGFTIANH
NAAAVGEICRRLDGIPLAIEFAAARVRSMSPLEIADGLDDCFRLLAGGVRGAVQRQQT
LRASIDWSHALLTETEQILFRRLAPFVGGFDLAAVRAVAAGSDLDPFSVLDQLTLLVD
KSLVVADDCQGRTRYRLLETVRRYALEKLGDSGEADVHARHRDYYTALAASLNTPADN
DHQRLVARAETEIDNLRAAFAWSRENGHITEALQLASSLQPIWFGRAHLREGLSWFNS
ILEDQRFHRLAVSTAVRARALADKAMLSTWLATSPVGATDIIAPAQQALAMAREVGDP
AALVRALTACGCSSGYNAEAAAPYFAEATDLARAIDDKWTLCQILYWRGVGTCISGDP
NALRAAAEECRDLADTIGDRFVSRHCSLWLSLAQMWAGNLTEALELSREITAEAEASN
DVPTKVLGLYTQAQVLAYCGASAAHAIAGACIAAATELGGVYQGIGYAAMTYAALAAG
DVTAALEASDAARPILRAQPDQVTMHQVLMAQLALAGGDAIAARQFANDAVDATNGWH
RMVALTIRARVATARGEPELARDDAHAALACGAELHIYQGMPDAMELLAGLAGEVGSH
SEGVRLLGAAAALRQQTRQVRFKIWDAGYQASVTALREAMGDEDFDRAWAEGAALSTD
EAIAYAQRGRGERKRPARGWGSLTPTERDVVRLVSEGLSNKDIAKRLFVSPRTVQTHL
THVYAKLGLPSRVQLVDEAARRGSPS"
gene complement(992598..993455)
/locus_tag="Rv0891c"
CDS complement(992598..993455)
/codon_start=1
/transl_table=11
/locus_tag="Rv0891c"
/product="Possible transcriptional regulatory protein"
/note="Rv0891c, (MTCY31.19c), len: 285 aa. Possible
transcriptional regulator, highly similar in N-terminus to
NP_302202.1|NC_002677 possible transcriptional regulator
from Mycobacterium leprae (1106 aa). Also highly similar
to several Mycobacterium tuberculosis putative
transcriptional regulators e.g. Q1102|MTCY02B10_22
probable transcriptional regulatory protein (1159 aa),
FASTA scores: opt: 702, E(): 8.3e-40, (50.6% identity in
247 aa overlap); MTV036_21; MTV008_44; MTCY02B10_23. Also
shows similarity with several adenylate cyclases and
hydrolases from other organisms."
/db_xref="EnsemblGenomes-Gn:Rv0891c"
/db_xref="EnsemblGenomes-Tr:CCP43639"
/db_xref="GOA:P9WMV1"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/Swiss-Prot:P9WMV1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43639.1"
/translation="MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARVRISALGS
LDLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEEST
HLWQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALD
LQRTSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVT
GRLPADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTT
FVGRRAQIS"
gene 993853..995340
/locus_tag="Rv0892"
CDS 993853..995340
/codon_start=1
/transl_table=11
/locus_tag="Rv0892"
/product="Probable monooxygenase"
/note="Rv0892, (MTCY31.20), len: 495 aa. Probable
monooxygenase, highly similar to others e.g.
NP_250787.1|NC_002516 probable flavin-binding
monooxygenase from Pseudomonas aeruginosa (491 aa);
CAB59668.1|AL132674 monooxygenase from Streptomyces
coelicolor (519 aa); P12015|CYMO_ACIS cyclohexanone
monooxygenase from Acinetobacter sp. (542 aa), FASTA
scores: opt: 489, E(): 6.8e-26, (30.3% identity in 492 aa
overlap); etc. Also highly similar to Rv0565c, Rv3854c,
Rv3083, etc from Mycobacterium tuberculosis. Has
hydrophobic stretch at N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv0892"
/db_xref="EnsemblGenomes-Tr:CCP43640"
/db_xref="GOA:P9WNG1"
/db_xref="InterPro:IPR020946"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WNG1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43640.1"
/translation="MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVCIYEKADDVGGT
WRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFG
ATVVSARFDDGRWVLRTDSGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVFHSAR
WDHTVPLLGRRIAVIGTGSTGVQLVCGLAGVAGKVTMFQRTAQWVLPWPNPRYSKLAR
VFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAVCRASLRRVRDPRLRRAL
TPDYEPMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLAT
GFDSHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPL
TAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYL
NKDGIPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA"
gene complement(995318..996295)
/locus_tag="Rv0893c"
CDS complement(995318..996295)
/codon_start=1
/transl_table=11
/locus_tag="Rv0893c"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv0893c, (MTCY31.21c), len: 325 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), belongs in family with
P96823|Rv0146|MTCI5.20 from Mycobacterium tuberculosis
(310 aa), FASTA scores: opt: 784, E(): 0, (43.2% identity
in 308 aa overlap); Rv0726c, Rv0731c, Rv3399, etc. Also
shows some similarity with others e.g. SC9B5.10|T35930
hypothetical protein from Streptomyces coelicolor (303
aa); BSUB0008_141|Q45500 hypothetical 34.8 kDa protein
from Bacillus subtilis (304 aa), FASTA scores: E():
0.00033,(26.8% identity in 168 aa overlap); etc. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0893c"
/db_xref="EnsemblGenomes-Tr:CCP43641"
/db_xref="GOA:P9WFI1"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFI1"
/protein_id="CCP43641.1"
/translation="MRTEDDSWDVTTSVGSTGLLVAAARALETQKADPLAIDPYAEVF
CRAAGGEWADVLDGKLPDHYLTTGDFGEHFVNFQGARTRYFDEYFSRATAAGMKQVVI
LAAGLDSRAFRLQWPIGTTIFELDRPQVLDFKNAVLADYHIRPRAQRRSVAVDLRDEW
QIALCNNGFDANRPSAWIAEGLLVYLSAEAQQRLFIGIDTLASPGSHVAVEEATPLDP
CEFAAKLERERAANAQGDPRRFFQMVYNERWARATEWFDERGWRATATPLAEYLRRVG
RAVPEADTEAAPMVTAITFVSAVRTGLVADPARTSPSSTSIGFKRFEAD"
gene 996524..997705
/locus_tag="Rv0894"
CDS 996524..997705
/codon_start=1
/transl_table=11
/locus_tag="Rv0894"
/product="Possible transcriptional regulatory protein
(possibly LuxR-family)"
/note="Rv0894, (MTCY31.22), len: 393 aa. Possible
regulatory protein, LuxR family, highly similar in part to
NP_302202.1|NC_002677 possible transcriptional regulator
from Mycobacterium leprae (1106 aa). Also similar to
others e.g. CAB95788.1|AL359949 putative multi-domain
regulatory protein from Streptomyces coelicolor (780 aa);
NP_107293.1|NC_002678 transcriptional regulator from
Mesorhizobium loti (903 aa); etc. Also similar to other
regulatory proteins from Mycobacterium tuberculosis e.g.
Rv2488c|MTV008_44 (1137 aa), FASTA score: (53.2% identity
in 363 aa overlap); Rv1358|MTCY02B10_22 (1159 aa), FASTA
score: (52.3% identity in 365 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0894"
/db_xref="EnsemblGenomes-Tr:CCP43642"
/db_xref="GOA:P9WKP9"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WKP9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43642.1"
/translation="MPSRATVQEFSDSYPFCHNGFRPIMMPKIVSVQHSTRRHLTSFV
GRKAELNDVRRLLSDKRLVTLTGPDGMGKSRLALQIGAQIAHEFTYGRWDCDLATVTD
RDCVSISMLNALGLPVQPGLSAIDTLVGVINDARVLLVLDHCEHLLDACAAIIDSLLR
SCPRLTILTTSTEAIGLAGELTWRVPPLSLTNDAIELFVDRARRVRSDFAINADTAVT
VGEICRRLDGVPLAIELAAARTDTLSPVEILAGLNDRFRLVAGAAGNAVRPEQTLCAT
VQWSHALLSGPERALLHRLAVFAGGFDLDGAQAVGANDEDFEGYQTLGRFAELVDKAF
VVVENNRGRAGYRLLYSVRQYALEKLSESGEADAVLARYRKHLKQPNQVVRAGSGGVR
Y"
gene 997782..999299
/locus_tag="Rv0895"
CDS 997782..999299
/codon_start=1
/transl_table=11
/locus_tag="Rv0895"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv0895, (MTCY31.23), len: 505 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004); member
of family with: Rv3740c, Rv3734c, Rv1425, Rv1760, etc.
Shows some similarity with NP_301898.1|NC_002677 conserved
membrane protein from Mycobacterium leprae (491 aa). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0895"
/db_xref="EnsemblGenomes-Tr:CCP43643"
/db_xref="GOA:P9WKA3"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WKA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43643.1"
/translation="MRQQQEADVVALGRKPGLLCVPERFRAMDLPMAAADALFLWAET
PTRPLHVGALAVLSQPDNGTGRYLRKVFSAAVARQQVAPWWRRRPHRSLTSLGQWSWR
TETEVDLDYHVRLSALPPRAGTAELWALVSELHAGMLDRSRPLWQVDLIEGLPGGRCA
VYVKVHHALADGVSVMRLLQRIVTADPHQRQMPTLWEVPAQASVAKHTAPRGSSRPLT
LAKGVLGQARGVPGMVRVVADTTWRAAQCRSGPLTLAAPHTPLNEPIAGARSVAGCSF
PIERLRQVAEHADATINDVVLAMCGGALRAYLISRGALPGAPLIAMVPVSLRDTAVID
VFGQGPGNKIGTLMCSLATHLASPVERLSAIRASMRDGKAAIAGRSRNQALAMSALGA
APLALAMALGRVPAPLRPPNVTISNVPGPQGALYWNGARLDALYLLSAPVDGAALNIT
CSGTNEQITFGLTGCRRAVPALSILTDQLAHELELLVGVSEAGPGTRLRRIAGRR"
gene 999472..1000767
/gene="gltA2"
/locus_tag="Rv0896"
CDS 999472..1000767
/codon_start=1
/transl_table=11
/gene="gltA2"
/locus_tag="Rv0896"
/product="Probable citrate synthase I GltA2"
/note="Rv0896, (MTCY31.24), len: 431 aa. Probable
gltA2,citrate synthase 1, highly similar to
O33066|NP_302405.1|NC_002677 citrate synthase 1 from
Mycobacterium leprae (431 aa), FASTA scores: E(): 0, (91.0
identity in 431 aa overlap); and
AAF04133.1|AF191033_1|AF191033 citrate synthase from
Mycobacterium smegmatis (441 aa). Also highly similar to
others e.g. AAF14286.1|AF181118_1|AF181118 citrate
synthase from Streptomyces coelicolor (429 aa);
P42457|CISY_CORGL citrate synthase from Corynebacterium
glutamicum (437 aa),FASTA scores: opt: 1847, E(): 0,
(63.0% identity in 433 aa overlap); etc. Also similar to
two other Mycobacterium tuberculosis citrate synthases,
Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (29.2%
identity in 274 aa overlap) and Rv1131|MTCY22G8.20|gltA1
(393 aa). Contains PS00480 Citrate synthase signature.
Belongs to the citrate synthase family."
/db_xref="EnsemblGenomes-Gn:Rv0896"
/db_xref="EnsemblGenomes-Tr:CCP43644"
/db_xref="GOA:P9WPD5"
/db_xref="InterPro:IPR002020"
/db_xref="InterPro:IPR010953"
/db_xref="InterPro:IPR016142"
/db_xref="InterPro:IPR016143"
/db_xref="InterPro:IPR019810"
/db_xref="InterPro:IPR024176"
/db_xref="InterPro:IPR036969"
/db_xref="PDB:4TVM"
/db_xref="UniProtKB/Swiss-Prot:P9WPD5"
/inference="protein motif:PROSITE:PS00480"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43644.1"
/translation="MADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTT
FDVGFANTAAAKSSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQ
LAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQV
ELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEV
VRALDMLFILHADHEQNCSTSTVRLVGSSRANLFTSISGGINALWGPLHGGANQAVLE
MLEGIRDSGDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRARIVKEQADKILAKLG
GDDSLLGIAKELEEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRL
PGWIAHWREMHDEGDSKIGRPRQIYTGYTERDYVTIDAR"
gene complement(1000808..1002415)
/locus_tag="Rv0897c"
CDS complement(1000808..1002415)
/codon_start=1
/transl_table=11
/locus_tag="Rv0897c"
/product="Probable oxidoreductase"
/note="Rv0897c, (MTCY31.25c), len: 535 aa. Possible
oxidoreductase, similar to various oxidoreductases from
diverse organisms e.g. CAB94055.1|AL358672 putative
oxidoreductase from Streptomyces coelicolor (540 aa);
NP_147877.1|NC_000854 phytoene dehydrogenase from
Aeropyrum pernix (549 aa); Q01671|CRTD_RHOSH
methoxyneurosporene dehydrogenase from Rhodobacter
sphaeroides (495 aa), FASTA scores: opt: 139, E():
2.6e-06, (23.8% identity in 538 aa overlap); etc. Also
similar to Rv1432, Rv2997, and Rv3829c from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0897c"
/db_xref="EnsemblGenomes-Tr:CCP43645"
/db_xref="GOA:P9WKP7"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WKP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43645.1"
/translation="MSDHDRDFDVVVVGGGHNGLVAAAYLARAGLRVRLLERLAQTGG
AAVSIQAFDGVEVALSRYSYLVSLLPSRIVADLGAPVRLARRPFSSYTPAPATAGRSG
LLIGPTGEPRAAHLAAIGAAPDAHGFAAFYRRCRLVTARLWPTLIEPLRTREQARRDI
VEYGGHEAAAAWQAMVDEPIGHAIAGAVANDLLRGVIATDALIGTFARMHEPSLMQNI
CFLYHLVGGGTGVWHVPIGGMGSVTSALATAAARHGAEIVTGADVFALDPDGTVRYHS
DGSDGAEHLVRGRFVLVGVTPAVLASLLGEPVAALAPGAQVKVNMVVRRLPRLRDDSV
TPQQAFAGTFHVNETWSQLDAAYSQAASGRLPDPLPCEAYCHSLTDPSILSARLRDAG
AQTLTVFGLHTPHSVFGDTEGLAERLTAAVLASLNSVLAEPIQDVLWTDAQSKPCIET
TTTLDLQRTLGMTGGNIFHGALSWPFADNDDPLDTPARQWGVATDHERIMLCGSGARR
GGAVSGIGGHNAAMAVLACLASRRKSP"
gene complement(1002441..1002704)
/locus_tag="Rv0898c"
CDS complement(1002441..1002704)
/codon_start=1
/transl_table=11
/locus_tag="Rv0898c"
/product="Conserved hypothetical protein"
/note="Rv0898c, (MTCY31.26c), len: 87 aa. Conserved
hypothetical protein, highly similar to
CAC01589.1|AL391041 hypothetical protein from Streptomyces
coelicolor (87 aa). Also shows some similarity to
Rv0709|MTCY210.28|rpmC from Mycobacterium tuberculosis (77
aa), FASTA score: (28.8% identity in 73 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0898c"
/db_xref="EnsemblGenomes-Tr:CCP43646"
/db_xref="InterPro:IPR020311"
/db_xref="UniProtKB/Swiss-Prot:P9WKP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43646.1"
/translation="MGKGRKPTDSETLAHIRDLVAEEKALRAQLRHGGISESEEQQQL
RRIEIELDQCWDLLRQRRALRQTGGDPREAVVRPADQVEGYTG"
gene 1002812..1003792
/gene="ompA"
/gene_synonym="ompATb"
/locus_tag="Rv0899"
CDS 1002812..1003792
/codon_start=1
/transl_table=11
/gene="ompA"
/gene_synonym="ompATb"
/locus_tag="Rv0899"
/product="Outer membrane protein A OmpA"
/note="Rv0899, (MTCY31.27), len: 326 aa. OmpA, outer
membrane protein A (See Senaratne et al., 1998).
C-terminal region similar to C-terminus of many members of
the OmpA family of outer membrane proteins, e.g.
NP_458280.1|NC_003198 putative outer membrane protein from
Salmonella enterica subsp. enterica serovar Typhi (220);
NP_418008.1|NC_000913 putative outer membrane protein from
Escherichia coli strain K12 (219 aa), FASTA scores: opt:
296, E(): 2.2e-11, (45.3% identity in 117 aa overlap);
NP_231844.1|NC_002505 outer membrane protein OmpA from
Vibrio cholerae (321 aa); Q05146|OMPA_BORAV outer membrane
protein A precursor from Bordetella avium (194 aa); etc. A
signal peptide sequence probably exists at the N-terminus.
N-terminal domain is necessary and sufficient for membrane
translocation (See Alahari et al., 2007). Contains PS00044
Bacterial regulatory proteins, lysR family signature.
Belongs to the OmpA family. Pore-forming activity is
pH-dependent."
/db_xref="EnsemblGenomes-Gn:Rv0899"
/db_xref="EnsemblGenomes-Tr:CCP43647"
/db_xref="GOA:P9WIU5"
/db_xref="InterPro:IPR006664"
/db_xref="InterPro:IPR006665"
/db_xref="InterPro:IPR006690"
/db_xref="InterPro:IPR007055"
/db_xref="InterPro:IPR036737"
/db_xref="PDB:2KGS"
/db_xref="PDB:2KGW"
/db_xref="PDB:2KSM"
/db_xref="PDB:2L26"
/db_xref="PDB:2LBT"
/db_xref="PDB:2LCA"
/db_xref="UniProtKB/Swiss-Prot:P9WIU5"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43647.1"
/translation="MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAA
IGYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAA
KAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTV
TLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAV
TGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQ
RAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN"
gene 1003805..1003957
/locus_tag="Rv0900"
CDS 1003805..1003957
/codon_start=1
/transl_table=11
/locus_tag="Rv0900"
/product="Possible membrane protein"
/note="Rv0900, (MTCY31.28), len: 50 aa. Possible membrane
protein, with hydrophobic domain from aa 4-26."
/db_xref="EnsemblGenomes-Gn:Rv0900"
/db_xref="EnsemblGenomes-Tr:CCP43648"
/db_xref="GOA:P9WJG7"
/db_xref="UniProtKB/Swiss-Prot:P9WJG7"
/protein_id="CCP43648.1"
/translation="MDFVIQWSCYLLAFLGGSAVAWVVVTLSIKRASRDEGAAEAPSA
AETGAQ"
gene 1003957..1004484
/locus_tag="Rv0901"
CDS 1003957..1004484
/codon_start=1
/transl_table=11
/locus_tag="Rv0901"
/product="Possible conserved exported or membrane protein"
/note="Rv0901, (MTCY31.29), len: 175 aa. Possible
conserved exported or membrane protein, with hydrophobic
N-terminus at aa 7-25. Shows some similarity in C-terminus
to O33070|Z99494|MLCB57.59 hypothetical protein from
Mycobacterium leprae (113 aa), FASTA scores: opt: 204,
E(): 3.2e-12, (44.9% identity in 78 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0901"
/db_xref="EnsemblGenomes-Tr:CCP43649"
/db_xref="GOA:P9WJG5"
/db_xref="UniProtKB/Swiss-Prot:P9WJG5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43649.1"
/translation="MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAK
SKPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIP
VVPYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESA
ARAFFTPWRKSTRRT"
gene complement(1004501..1005841)
/gene="prrB"
/locus_tag="Rv0902c"
CDS complement(1004501..1005841)
/codon_start=1
/transl_table=11
/gene="prrB"
/locus_tag="Rv0902c"
/product="Two component sensor histidine kinase PrrB"
/note="Rv0902c, (MTCY31.30c), len: 446 aa.
PrrB,two-component sensor histidine kinase (see citations
below), transmembrane protein, equivalent to
MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase
from Mycobacterium leprae (446 aa); and similar at
C-termini to NP_301251.1|NC_002677 putative two-component
system sensor kinase from Mycobacterium leprae (519 aa).
C-terminus also similar to the C-termini of many
sensor-like histidine kinase proteins e.g.
P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor
protein from Escherichia coli strain K12 (457 aa), FASTA
scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa
overlap); CAB89748.1|AL354616 putative two-component
histidine kinase from Streptomyces coelicolor (483 aa);
CAB82845.1|AJ277081 putative histidine kinase from
Amycolatopsis mediterranei (472 aa); etc. Also similar in
part to Mycobacterium tuberculosis proteins Rv3764c (475
aa); and Rv0982 (504 aa). Thought to be induced at
phagocytosis (see Graham & Clark-Curtiss 1999)."
/db_xref="EnsemblGenomes-Gn:Rv0902c"
/db_xref="EnsemblGenomes-Tr:CCP43650"
/db_xref="GOA:P9WGK7"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="PDB:1YS3"
/db_xref="PDB:1YSR"
/db_xref="UniProtKB/Swiss-Prot:P9WGK7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43650.1"
/translation="MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITND
RKERLDRRLDEAAGFAIPFVPRGLDEIPRSPNDQDALITVRRGNVIKSNSDITLPKLQ
DDYADTYVRGVRYRVRTVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGA
AAVFAWLLAAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIW
NEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVLNDVIRT
QSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARIYPDLDVSLVPSPTC
IIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAVSSRAGVEIAIDDNGSGVPEGERQV
VFERFSRGSTASHSGSGLGLALVAQQAQLHGGTASLENSPLGGARLVLRLPGPS"
gene complement(1005852..1006562)
/gene="prrA"
/locus_tag="Rv0903c"
CDS complement(1005852..1006562)
/codon_start=1
/transl_table=11
/gene="prrA"
/locus_tag="Rv0903c"
/product="Two component response transcriptional
regulatory protein PrrA"
/note="Rv0903c, (MTCY31.31c), len: 236 aa.
PrrA,two-component response regulator (see citations
below),equivalent to
Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component
response regulator from Mycobacterium leprae (233 aa),
FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa
overlap); and similar to T45446 probable two-component
response regulator from Mycobacterium leprae (253 aa).
Also similar to many sensor-like histidine kinase proteins
e.g. CAB88489.1|AL353816 putative two-component systen
response regulator from Streptomyces coelicolor (248 aa);
AAG36759.1|AF119221_1 |AF119221 response regulator from
Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM
transcriptional activator protein COPR from Pseudomonas
syringae (pv. tomato) (227 aa), FASTA scores: opt:
600,E(): 0, (44.4% identity in 225 aa overlap); etc. Also
similar to Rv0981 from Mycobacterium tuberculosis (230
aa),Rv3765c (234 aa), phoP (247 aa), etc. Thought to be
induced at phagocytosis (see Graham & Clark-Curtiss
1999)."
/db_xref="EnsemblGenomes-Gn:Rv0903c"
/db_xref="EnsemblGenomes-Tr:CCP43651"
/db_xref="GOA:P9WGM1"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="PDB:1YS6"
/db_xref="PDB:1YS7"
/db_xref="UniProtKB/Swiss-Prot:P9WGM1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43651.1"
/translation="MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGA
EALRSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLE
AGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVD
VDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGG
GPRLLHTVRGVGFVLRMQ"
gene complement(1006693..1008180)
/gene="accD3"
/locus_tag="Rv0904c"
CDS complement(1006693..1008180)
/codon_start=1
/transl_table=11
/gene="accD3"
/locus_tag="Rv0904c"
/product="Putative acetyl-coenzyme A carboxylase carboxyl
transferase (subunit beta) AccD3 (accase beta chain)"
/note="Rv0904c, (MTCY31.32c, MT0927), len: 495 aa.
Putative accD3, acetyl-CoA carboxylase carboxyl
transferase, beta subunit (carboxyltransferase subunit of
acetyl-CoA carboxylase), highly similar in part to
AAA63045.1|U15184 zinc finger protein from Mycobacterium
leprae (201 aa). Also highly similar to others e.g.
CAC42827.1|Y17592 putative carboxyltransferase subunit of
acetyl-CoA carboxylase from Corynebacterium glutamicum
(491 aa); CAB86110.1|AL163003 putative acetyl CoA
carboxylase (alpha and beta subunits) from Streptomyces
coelicolor (458 aa); Q54776|ACCD_SYNP7 acetyl-coenzyme A
carboxylase carboxyl transferase subunit beta from
Synechococcus sp. (305 aa); P12217|ACCD_MARPO
acetyl-coenzyme A carboxylase carboxyl transferase subunit
beta from Marchantia polymorpha (316 aa), FASTA scores:
opt: 519, E():1.6e-24, (40.2% identity in 219 aa overlap);
etc. Also similar to Rv3280, Rv2502c,etc from
Mycobacterium tuberculosis. Belongs to the ACCD/PCCB
family."
/db_xref="EnsemblGenomes-Gn:Rv0904c"
/db_xref="EnsemblGenomes-Tr:CCP43652"
/db_xref="GOA:P9WQH9"
/db_xref="InterPro:IPR000438"
/db_xref="InterPro:IPR011762"
/db_xref="InterPro:IPR011763"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR034733"
/db_xref="UniProtKB/Swiss-Prot:P9WQH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43652.1"
/translation="MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARA
ATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLA
SPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHL
TVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRAL
TVLIDAPEPLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQ
GEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVL
VIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRV
LAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAA
DEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD"
gene 1008207..1008938
/gene="echA6"
/locus_tag="Rv0905"
CDS 1008207..1008938
/codon_start=1
/transl_table=11
/gene="echA6"
/locus_tag="Rv0905"
/product="Possible enoyl-CoA hydratase EchA6 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv0905, (MTCY31.33), len: 243 aa. Possible
echA6,enoyl-CoA hydratase, highly similar to
ML15184|U15184 enoyl-CoA hydratase from Mycobacterium
leprae (247 aa),FASTA score: (85.8% identity in 247 aa
overlap). Also similar to many e.g. NP_250320.1|NC_002516
probable enoyl-CoA hydratase/isomerase from Pseudomonas
aeruginosa (261 aa); NP_415911.1|NC_000913 putative enzyme
from Escherichia coli strain K12 (255 aa);
P24162|ECHH_RHOCA|FADB1 enoyl-CoA hydratase homolog from
Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257
aa), FASTA scores: opt: 404, E():7.8e-21, (37.3% identity
in 249 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0905"
/db_xref="EnsemblGenomes-Tr:CCP43653"
/db_xref="GOA:P9WNP1"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="PDB:3HE2"
/db_xref="PDB:5DTP"
/db_xref="PDB:5DTW"
/db_xref="PDB:5DU4"
/db_xref="PDB:5DU6"
/db_xref="PDB:5DU8"
/db_xref="PDB:5DUC"
/db_xref="PDB:5DUF"
/db_xref="UniProtKB/Swiss-Prot:P9WNP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43653.1"
/translation="MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSA
RAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGL
QLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAE
IALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDK
AWGSQDVIEAQVARMEKRPPKFQGA"
gene 1008944..1010062
/locus_tag="Rv0906"
CDS 1008944..1010062
/codon_start=1
/transl_table=11
/locus_tag="Rv0906"
/product="Conserved protein"
/note="Rv0906, (MTCY31.34), len: 372 aa. Conserved
protein,highly similar to others e.g.
SC6A5.25|AL049485|T35416 hypothetical protein from
Streptomyces coelicolor (370 aa),FASTA scores: opt: 1125,
E(): 0, (51.3% identity in 335 aa overlap);
NP_242955.1|NC_002570|BH2089 conserved protein from
Bacillus halodurans (370 aa); etc. Also shows some
similarity to C-terminus of Q48412|ROMA_KLEPN Q48412 outer
membrane protein roma (fragment) from Klebsiella
pneumoniae (132 aa), FASTA scores: opt: 319, E(): 8.5e-14,
(46.2% identity in 104 aa overlap); NP_105215.1|NC_002678
hypothetical protein which contains similarity to outer
membrane protein romA from Enterobacter cloacae (350 aa);
etc. Predicted to be an outer membrane protein (See Song
et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0906"
/db_xref="EnsemblGenomes-Tr:CCP43654"
/db_xref="GOA:P9WKP3"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR024884"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/Swiss-Prot:P9WKP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43654.1"
/translation="MVRRALRLAAGTASLAAGTWLLRALHGTPAALGADAASIRAVSE
QSPNYRDGAFVNLDPASMFTLDREELRLIVWELVARHSASRPAAPIPLASPNIYRGDA
SRLAVSWFGHSTALLEIDGYRVLTDPVWSDRCSPSDVVGPQRLHPPPVQLAALPAVDA
VVISHDHYDHLDIDTVVALVGMQRAPFLVPLGVGAHLRSWGVPQDRIVELDWNQSAQV
DELTVVCVPARHFSGRFLSRNTTLWASWAFVGPNHRAYFGGDTGYTKSFTQIGADHGP
FDLTLLPIGAYNTAWPDIHMNPEEAVRAHLDVTDSGSGMLVPVHWGTFRLAPHPWGEP
VERLLAAAEPEHVTVAVPLPGQRVDPTGPMRLHPWWRL"
gene 1010136..1011734
/locus_tag="Rv0907"
CDS 1010136..1011734
/codon_start=1
/transl_table=11
/locus_tag="Rv0907"
/product="Conserved protein"
/note="Rv0907, (MTCY21C12.01), len: 532 aa. Conserved
protein, possibly involved in cell wall biosynthesis:
similar to many beta-lactamases, penicillin-binding
proteins and hypothetical proteins e.g.
NP_298910.1|NC_002488 beta-lactamase from Xylella
fastidiosa (455 aa); Q06317|PBP4_NOCLA penicillin-binding
protein 4 (PBP-4) (381 aa), FASTA scores: opt: 299, E():
8.8e-05, (28.7% identity in 401 aa overlap); etc.
N-terminus highly similar to AAA63047.1|U15184
hypothetical protein from Mycobacterium leprae (58 aa).
Related to other putative esterases and penicillin binding
proteins in Mycobacterium tuberculosis e.g.
Rv1730c|MTCY04C12.15c (517 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0907"
/db_xref="EnsemblGenomes-Tr:CCP43655"
/db_xref="GOA:O05900"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR021860"
/db_xref="UniProtKB/TrEMBL:O05900"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43655.1"
/translation="MATICGHDQTSGNGRHGDVADVNGCGSTHQALGPPSGLPDASPN
ERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHGGKTLYAKGFGVRDVGK
GGGPDNKVDADTVFQLASVSKSVGATVVAHAVTDNVVTWDTPVVSKLPWFALRDPYVT
GQVTIADLYSHRSGLPDHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFGVTA
AAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEARY
QRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYTPQVISRHPV
SPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLGAAANFVVLPSEDLAIIALTNAGPI
GVPETLTAEFMDLVQYGQVREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLND
YVGVYANDYWGPATVTYHDGQLRLSLGPKNQTFDLTHWDGDTFTFTLSTENALPGSIS
KATFAGDTLNLEYYDADKLGTFTR"
gene 1011731..1014124
/gene="ctpE"
/locus_tag="Rv0908"
CDS 1011731..1014124
/codon_start=1
/transl_table=11
/gene="ctpE"
/locus_tag="Rv0908"
/product="Probable metal cation transporter ATPase P-type
CtpE"
/note="Rv0908, (MTCY21C12.02), len: 797 aa. Probable
ctpE,metal cation-transporting ATPase P-type,
transmembrane protein, E1-E2 family, highly similar to
many e.g. AB93406.1|AL357524 putative integral membrane
ATPase from Streptomyces coelicolor (802 aa);
NP_346063.1|NC_003028 cation-transporting ATPase (E1-E2
family) from Streptococcus pneumoniae (778 aa);
P37278|ATCL_SYNP7|PACL cation-transporting atpase from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(926 aa), FASTA scores: opt: 257, E(): 4.8e-33, (27.7%
identity in 905 aa overlap); etc. Contains E1-E2 ATPases
phosphorylation site (PS00154). Belongs to the cation
transport ATPases family (E1-E2 ATPases)."
/db_xref="EnsemblGenomes-Gn:Rv0908"
/db_xref="EnsemblGenomes-Tr:CCP43656"
/db_xref="GOA:P9WPT1"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPT1"
/inference="protein motif:PROSITE:PS00154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43656.1"
/translation="MTRSASATAGLTDAEVAQRVAEGKSNDIPERVTRTVGQIVRANV
FTRINAILGVLLLIVLATGSLINGMFGLLIIANSVIGMVQEIRAKQTLDKLAIIGQAK
PLVRRQSGTRTRSTNEVVLDDIIELGPGDQVVVDGEVVEEENLEIDESLLTGEADPIA
KDAGDTVMSGSFVVSGAGAYRATKVGSEAYAAKLAAEASKFTLVKSELRNGINRILQF
ITYLLVPAGLLTIYTQLFTTHVGWRESVLRMVGALVPMVPEGLVLMTSIAFAVGVVRL
GQRQCLVQELPAIEGLARVDVVCADKTGTLTESGMRVCEVEELDGAGRQESVADVLAA
LAAADARPNASMQAIAEAFHSPPGWVVAANAPFKSATKWSGVSFRDHGNWVIGAPDVL
LDPASVAARQAERIGAQGLRVLLLAAGSVAVDHAQAPGQVTPVALVVLEQKVRPDARE
TLDYFAVQNVSVKVISGDNAVSVGAVADRLGLHGEAMDARALPTGREELADTLDSYTS
FGRVRPDQKRAIVHALQSHGHTVAMTGDGVNDVLALKDADIGVAMGSGSPASRAVAQI
VLLNNRFATLPHVVGEGRRVIGNIERVANLFLTKTVYSVLLALLVGIECLIAIPLRRD
PLLFPFQPIHVTIAAWFTIGIPAFILSLAPNNERAYPGFVRRVMTSAVPFGLVIGVAT
FVTYLAAYQGRYASWQEQEQASTAALITLLMTALWVLAVIARPYQWWRLALVLASGLA
YVVIFSLPLAREKFLLDASNLATTSIALAVGVVGAATIEAMWWIRSRMLGVKPRVWR"
gene 1014681..1014860
/locus_tag="Rv0909"
CDS 1014681..1014860
/codon_start=1
/transl_table=11
/locus_tag="Rv0909"
/product="Conserved hypothetical protein"
/note="Rv0909, (MTCY21C12.03), len: 59 aa. Conserved
hypothetical protein, equivalent to NP_302399.1|NC_002677
conserved hypothetical protein from Mycobacterium leprae
(56 aa). Also some similarity with AL022268|SC4H2_10c
hypothetical protein from Streptomyces coelicolor (97
aa),FASTA scores: opt: 106, E(): 0.13, (43.2% identity in
37 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0909"
/db_xref="EnsemblGenomes-Tr:CCP43657"
/db_xref="GOA:P9WJ07"
/db_xref="InterPro:IPR028037"
/db_xref="UniProtKB/Swiss-Prot:P9WJ07"
/protein_id="CCP43657.1"
/translation="MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKL
HDAASNVVGMSDQQS"
gene 1014866..1015300
/locus_tag="Rv0910"
CDS 1014866..1015300
/codon_start=1
/transl_table=11
/locus_tag="Rv0910"
/product="Conserved hypothetical protein"
/note="Rv0910, (MTCY21C12.04), len: 144 aa. Conserved
hypothetical protein, equivalent to NP_302398.1|NC_002677
conserved hypothetical protein from Mycobacterium leprae
(181 aa), FASTA scores: opt: 820, E(): 0, (83.9% identity
in 143 aa overlap). Also similar to Rv1546|MTCY48.19c
hypothetical protein from Mycobacterium tuberculosis (143
aa). A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0910"
/db_xref="EnsemblGenomes-Tr:CCP43658"
/db_xref="GOA:P9WJ05"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/Swiss-Prot:P9WJ05"
/protein_id="CCP43658.1"
/translation="MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEV
LEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLNGDGVGGVKVKLIAKVAPKEHGS
VVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG"
gene 1015398..1016171
/locus_tag="Rv0911"
CDS 1015398..1016171
/codon_start=1
/transl_table=11
/locus_tag="Rv0911"
/product="Conserved protein"
/note="Rv0911, (MTCY21C12.05), len: 257 aa. Conserved
protein, showing similarity with hydroxylases and
hypothetical proteins e.g. T35325 probable hydroxylase
from Streptomyces coelicolor (265 aa); Q54242 hypothetical
protein from Streptomyces, FASTA scores: opt: 372, E():
8.8e-18, (32.0% identity in 256 aa overlap);
AAD04716.1|U77891 doxorubicin biosynthesis enzyme DnrV
from Streptomyces peucetius (275 aa); AAA63051.1|U15184
hypothetical protein from Mycobacterium leprae (94 aa);
etc. Also similar to Rv0577 hypothetical protein from
Mycobacterium tuberculosis (261 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0911"
/db_xref="EnsemblGenomes-Tr:CCP43659"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="InterPro:IPR041581"
/db_xref="UniProtKB/TrEMBL:I6XA34"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43659.1"
/translation="MPTRSSAPLGAPCWIDLTTSDVDRAQDFYGTVFGWAFESAGPDY
GGYINAAKGGHPVAGLMANRPEFQSPDGWATYFHTVDIGATVAKLAAAGGSSCLDPME
VPGKGFMSLAVDPSGAAFGLWQPLQHHGFEVIGEAGSPVWHQLTTRDYRSVIDFYRQV
FGWRTEQISDTDEFCYTTAWFDDQQLLGVMDGSSCLPEGVPSNWTIFFGAEDVDETLR
VICDNGGSVVRAAENTPYGRLAAAADPMGVVFNLSSLQA"
gene 1016236..1016685
/locus_tag="Rv0912"
CDS 1016236..1016685
/codon_start=1
/transl_table=11
/locus_tag="Rv0912"
/product="Probable conserved transmembrane protein"
/note="Rv0912, (MTCY21C12.06), len: 149 aa. Probable
conserved transmembrane protein, equivalent to
Q50121|NP_302397.1|NC_002677 conserved hypothetical
protein from Mycobacterium leprae (144 aa), FASTA scores:
opt: 677,E(): 6.9e-38, (69.5% identity in 141 aa overlap).
A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0912"
/db_xref="EnsemblGenomes-Tr:CCP43660"
/db_xref="GOA:O05904"
/db_xref="UniProtKB/TrEMBL:O05904"
/protein_id="CCP43660.1"
/translation="MTRRLRPGWLVALSAAVIAASTWMPWLTTTVGGGGWVNAIGGTH
GSLELPHGFGPGQLIVLLSSTLLVVGAMAGRGLSVKLSSIAALVVSLLIVALTVWYYK
LNVNPPVSAEYGLYFGAAGGVCAVGCSLWAAVSAASPGRRRHREVVR"
gene complement(1017217..1018725)
/locus_tag="Rv0913c"
CDS complement(1017217..1018725)
/codon_start=1
/transl_table=11
/locus_tag="Rv0913c"
/product="Possible dioxygenase"
/note="Rv0913c, (MTCY21C12.07c), len: 502 aa. Possible
dioxygenase, showing similarity with others e.g.
AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage
dioxygenase from Phaseolus vulgaris (543 aa);
CAB56138.1|AL117669 putative dioxygenase from Streptomyces
coelicolor (503 aa); AAK06796.1|AF324838_15|AF324838
putative dioxygenase SimC5 from Streptomyces antibioticus
(456 aa); Q53353|S65040
lignostilbene-alpha,beta-dioxygenase from Pseudomonas
paucimobilis (485 aa), FASTA scores: opt: 310, E():
3.4e-20, (28.9% identity in 495 aa overlap); etc. Also
some similarity with Rv0654|MTCI376.22 probable
dioxygenase from Mycobacterium tuberculosis (501 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0913c"
/db_xref="EnsemblGenomes-Tr:CCP43661"
/db_xref="GOA:I6Y551"
/db_xref="InterPro:IPR004294"
/db_xref="UniProtKB/TrEMBL:I6Y551"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43661.1"
/translation="MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGE
VPADLDGIYLRNTENPLHPAFATYHPFDGDGMIHVVGFRDGKAFYRNRFIRTDGFLAE
NEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHRGIALTSFYQCGDLYRI
DPYSANTLGKESWHGRFPFDWGVSAHPKVDNKTGELLFFNYSKQEPYMRYGVVDQNNE
LVHYVDVPLPGPRLPHDMAFTENYVILNDFPLFWDPRLLERDVHLPRFYPEIPSRFAV
VARRGNDIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQPLDTGGTKWEKLFRFL
ALDRLQSRLHRWRLNMVTGAVHEEQLSESITEFGTINADYAASSYRYTYAATGKPSWF
LFDGLVKHDLLTGNHECYSFGDGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASY
CLVFDAARPGDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL"
gene complement(1018727..1019965)
/locus_tag="Rv0914c"
CDS complement(1018727..1019965)
/codon_start=1
/transl_table=11
/locus_tag="Rv0914c"
/product="Possible lipid carrier protein or keto acyl-CoA
thiolase"
/note="Rv0914c, (MTCY21C12.08c), len: 412 aa. Possible
lipid carrier protein or keto acyl-CoA thiolase, highly
similar to NP_421905.1|NC_002696 thiolase family protein
from Caulobacter crescentus (407 aa); and similar to
others e.g. NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase
from Mesorhizobium loti (392 aa); NP_385796.1|NC_003047
putative 3-ketoacyl-CoA thiolase protein from
Sinorhizobium meliloti (389 aa); NP_275932.1|NC_000916
lipid-transfer protein (sterol or nonspecific) from
Methanothermobacter thermautotrophicus (383 aa);
AB55378.1|AL117263 possible 3-ketoacyl-CoA thiolase from
Leishmania major (441 aa),FASTA scores: opt: 547, E():
3.1e-26, (31.0% identity in 435 aa overlap); etc. Also
similar to Rv2790c, Rv1627c,Rv0244, etc from Mycobacterium
tuberculosis. Could belong to the thiolase family."
/db_xref="EnsemblGenomes-Gn:Rv0914c"
/db_xref="EnsemblGenomes-Tr:CCP43662"
/db_xref="GOA:I6XWJ8"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/TrEMBL:I6XWJ8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43662.1"
/translation="MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVD
AADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDDLWDTPATRHEAACASGSVATLA
AMADLRSGAYRVALVVGLELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVA
DEYDRRYGLDDTHLRAIAQLNFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRR
FDCSQMTDGGAGLVLVSDAYLRDHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSA
PYLLPHVRATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIE
NGEIEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAEAFGTL
NFGGSTATTVSFVVSTTRGS"
gene complement(1020058..1021329)
/gene="PPE14"
/gene_synonym="MTB41"
/locus_tag="Rv0915c"
CDS complement(1020058..1021329)
/codon_start=1
/transl_table=11
/gene="PPE14"
/gene_synonym="MTB41"
/locus_tag="Rv0915c"
/product="PPE family protein PPE14"
/note="Rv0915c, (MTCY21C12.09c), len: 423 aa. PPE14
(alternate gene name: MTB41). Member of the Mycobacterium
tuberculosis PPE family (see citation below), highly
similar to many e.g. Rv1807 from Mycobacterium
tuberculosis (403 aa), FASTA scores: opt: 966, E():
4.4e-30, (45.7% identity in 392 aa overlap); etc. Contains
PS00626 Regulator of chromosome condensation (RCC1)
signature 2."
/db_xref="EnsemblGenomes-Gn:Rv0915c"
/db_xref="EnsemblGenomes-Tr:CCP43663"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI33"
/inference="protein motif:PROSITE:PS00626"
/protein_id="CCP43663.1"
/translation="MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVS
YGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFA
MTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAA
ASALPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAA
NADPLTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTA
RPWHIGLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVP
HSWTTAAPEIQLAVQATPTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGT
RSGTSTDGQEDGRKPPVVVIREQPPPGNPPR"
gene complement(1021344..1021643)
/gene="PE7"
/gene_synonym="MTB10"
/locus_tag="Rv0916c"
CDS complement(1021344..1021643)
/codon_start=1
/transl_table=11
/gene="PE7"
/gene_synonym="MTB10"
/locus_tag="Rv0916c"
/product="PE family protein PE7"
/note="Rv0916c, (MTCY21C12.10c), len: 99 aa. PE7
(alternate gene name: MTB10). Member of the Mycobacterium
tuberculosis PE family (see citations below), similar to
many e.g. Rv1788 from Mycobacterium tuberculosis (99 aa),
FASTA scores: opt: 321, E(): 1.3e-11, (53.5% identity in
99 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0916c"
/db_xref="EnsemblGenomes-Tr:CCP43664"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:I6Y936"
/protein_id="CCP43664.1"
/translation="MSFVTIQPVVLAAATGDLPTIGTAVSARNTAVCAPTTGVLPPAA
NDVSVLTAARFTAHTKHYRVVSKPAALVHGMFVALPAATADAYATTEAVNVVATG"
gene 1022087..1023868
/gene="betP"
/locus_tag="Rv0917"
CDS 1022087..1023868
/codon_start=1
/transl_table=11
/gene="betP"
/locus_tag="Rv0917"
/product="Possible glycine betaine transport integral
membrane protein BetP"
/note="Rv0917, (MTCY21C12.11), len: 593 aa. Possible
betP,glycine betaine transporter, integral membrane
protein,highly similar to many transporters, mainly
glycine betaine transporters, e.g. P54582|BETP_CORGL
glycine betaine transporter from Corynebacterium
glutamicum (Brevibacterium flavum) (595 aa), FASTA scores:
opt: 1367, E(): 0, (42.7% identity in 504 aa overlap);
T35264 probable BccT family transporter from Streptomyces
coelicolor (578 aa); NP_243511.1|NC_002570 glycine betaine
transporter from Bacillus halodurans (504 aa);
NP_439848.1|NC_000907 high-affinity choline transport
protein (betT) from Haemophilus influenzae (669 aa); etc.
Seems to belong to the BCCT (TC 2.33) family of
transporters."
/db_xref="EnsemblGenomes-Gn:Rv0917"
/db_xref="EnsemblGenomes-Tr:CCP43665"
/db_xref="GOA:P9WPR7"
/db_xref="InterPro:IPR000060"
/db_xref="InterPro:IPR018093"
/db_xref="UniProtKB/Swiss-Prot:P9WPR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43665.1"
/translation="MSAKERGDQNAVVDALRSIQPAVFIPASVVIVAMIVVSVVYSSV
AENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFSFWAW
LAMLFSAGMGIGLVFYGVAEPLSHYLRPPRSRGVPALTDAAANQAMALTVFHWGLHAW
AIYVVVGLGMAYMTYRRGRPLSVRWLLEPVVGRGRVEGALGHAVDVIAIVGTLFGVAT
SLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATASVVSGVSKGLKWLSNINMA
LAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWLGDWTIFYWG
WWISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDM
LVNGAVDTNTSLFRLLDGLPIGAITSVLAVLVIVFFFVTSSDSGSLVIDILSAGGELD
PPKLTRVYWAVLEGVAAAVLLLIGGAGSLTALRTAAIATALPFSIVMVVACYAMTKAF
HFDLAATPRLLHVTVPDVVAAGNRRRHDISATLSGLIAVRDVDSGTYIVHPDTGALTV
TAPPDPLDDHVFESDRHVTRRNTTSSR"
gene 1024211..1024687
/locus_tag="Rv0918"
CDS 1024211..1024687
/codon_start=1
/transl_table=11
/locus_tag="Rv0918"
/product="Conserved protein"
/note="Rv0918, (MTCY21C12.12), len: 158 aa. Conserved
protein, similar in part to Q50116 hypothetical protein
from Mycobacterium leprae (44 aa), FASTA scores: opt:
132,E(): 0.0055, (65.6% identity in 32 aa overlap). Also
some similarity in C-terminus with other hypothetical
proteins e.g. NP_289961.1|NC_002655 hypothetical protein
from Escherichia coli strain O157:H7 (94 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0918"
/db_xref="EnsemblGenomes-Tr:CCP43666"
/db_xref="GOA:O05910"
/db_xref="InterPro:IPR010985"
/db_xref="InterPro:IPR014795"
/db_xref="InterPro:IPR016547"
/db_xref="UniProtKB/TrEMBL:O05910"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43666.1"
/translation="MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSL
GSSGLPALNCTPIRHTIDVMATKPERKTERLAARLTPEQDALIRRAAEAEGTDLTNFT
VTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG"
gene 1024684..1025184
/locus_tag="Rv0919"
CDS 1024684..1025184
/codon_start=1
/transl_table=11
/locus_tag="Rv0919"
/product="GCN5-related N-acetyltransferase"
/note="Rv0919, (MTCY21C12.13), len: 166 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain. See Vetting et al. 2005. Some
similarity to Q50115 hypothetical protein from
Mycobacterium leprae (90 aa), FASTA scores: opt: 243, E():
5.3e-11, (56.5% identity in 85 aa overlap). Alternative
nucleotide at position 1025106 (T->C; F141F) has been
observed."
/db_xref="EnsemblGenomes-Gn:Rv0919"
/db_xref="EnsemblGenomes-Tr:CCP43667"
/db_xref="GOA:I6XA42"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:I6XA42"
/protein_id="CCP43667.1"
/translation="MSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSR
CFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPDPVPVILLSRLAVDRKEQGRGLG
SHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD"
gene complement(1025321..1025393)
/gene="argT"
tRNA complement(1025321..1025393)
/gene="argT"
/product="tRNA-Arg"
/anticodon=(pos:complement(1025358..1025360),aa:Arg,
seq:cct)
/note="codon recognized: AGG; argT, tRNA-Arg, anticodon
cct, length = 73"
mobile_element complement(1025458..1026893)
/mobile_element_type="insertion sequence:IS1554"
/note="IS1554, len: 1436 nt. Putative Insertion sequence
element bounded by 15 bp inverted repeats."
repeat_region 1025458..1025472
/note="15 bp inverted repeat, ATTCGGTGTAAGTGG, at the left
end of IS1554 element"
gene complement(1025497..1026816)
/locus_tag="Rv0920c"
CDS complement(1025497..1026816)
/codon_start=1
/transl_table=11
/locus_tag="Rv0920c"
/product="Probable transposase"
/note="Rv0920c, (MTCY21C12.14c), len: 439 aa. Probable
transposase for IS1554, highly similar to others e.g.
MTCY441.35|Q45111 transposase from Mycobacterium
tuberculosis (419 aa), FASTA scores: opt: 1113, E():
0,(43.9% identity in 378 aa overlap); etc. Contains
transposases mutator family signature (PS01007)."
/db_xref="EnsemblGenomes-Gn:Rv0920c"
/db_xref="EnsemblGenomes-Tr:CCP43668"
/db_xref="GOA:I6Y941"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/TrEMBL:I6Y941"
/inference="protein motif:PROSITE:PS01007"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43668.1"
/translation="MDAAQVIEPAHAGQDVDEAAVAARELSGAERALVGDLVRQARAE
GVALTGPDGLLKALTKTVLEAALQEEMTEHLGYDRHAAAGRGSGNSRNGSRNKKVITD
ACGQVEIAVPRDRNGTFEPVIVGKRKRRVTDVDRVVLSLYAKGLTTGEIAAHFADVYG
VSVSKDTISRITDRVIEEMQAWWSRPLEKVYAAVFIDAIMVKIRDGQVRNRPVYAAIG
VDLDGHKDILGMWAGEGDGESAKFWLAVLTDLRNRGVKDIFFLVCDGLKGLPDSVSAA
FPLATVQTCIIHLIRNTFRYASRKYWDKISVDLKPIYTAASAAEARLRYEEFAEKWGK
PYPAITRLWDSAWEEFIPFLDYDVEIRRVPCSTNAIESLNARYRRAVRARGHFPNEQS
ALKTLYLVTRSLDPKGTGQTKWAVRWKPALNALAITFADRMPAAEER"
repeat_region complement(1026879..1026893)
/note="15 bp inverted repeat, ATTCGGTGTAAGTGG, at the
right end of IS1554 element"
mobile_element 1027061..1029360
/mobile_element_type="insertion sequence:IS1535"
/note="IS1535, len: 2300 nt. Putative Insertion sequence
element bounded by 16 bp inverted repeats."
repeat_region 1027061..1027076
/note="16 bp inverted repeat, TTGAGTGTGTTTTAGT, at the
left end of IS element IS1535"
gene 1027104..1027685
/locus_tag="Rv0921"
CDS 1027104..1027685
/codon_start=1
/transl_table=11
/locus_tag="Rv0921"
/product="Possible resolvase"
/note="Rv0921, (MTCY21C12.15), len: 193 aa. Possible
resolvase for IS1535, highly similar to many bacterial
resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from
Mycobacterium tuberculosis (295 aa), FASTA scores: opt:
537, E(): 5.7e-29, (51.8% identity in 166 aa overlap).
Presents an helix turn helix motif."
/db_xref="EnsemblGenomes-Gn:Rv0921"
/db_xref="EnsemblGenomes-Tr:CCP43669"
/db_xref="GOA:I6WZS4"
/db_xref="InterPro:IPR006119"
/db_xref="InterPro:IPR036162"
/db_xref="InterPro:IPR041718"
/db_xref="PDB:6DGB"
/db_xref="UniProtKB/TrEMBL:I6WZS4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43669.1"
/translation="MNLADWAESVGVNRHTAYRWFREGTLPVPAERVGRLILVKTAAS
ASAAAAGVVLYARVSSHDRRSDLDRQVARLTAWATERDLGVGQVVCEVGSGLNGKRPK
LRRILSDPDARVIVVEHRDRLARFGVEHLEAALSAQGRRIVVADPGETTDDLVCDMIE
VLTGMCARLYGRRGARNRAMRAVTEAKREPGAG"
gene 1027685..1029337
/locus_tag="Rv0922"
CDS 1027685..1029337
/codon_start=1
/transl_table=11
/locus_tag="Rv0922"
/product="Possible transposase"
/note="Rv0922, (MTCY21C12.16), len: 550 aa. Possible
transposase for IS1535, similar to many e.g.
YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium
tuberculosis (460 aa), FASTA scores: opt 939, E():
0,(40.6% identity in 465 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0922"
/db_xref="EnsemblGenomes-Tr:CCP43670"
/db_xref="InterPro:IPR001959"
/db_xref="UniProtKB/TrEMBL:I6Y560"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43670.1"
/translation="MIVRMRSCAQAAKVAEATGGVQLAGKPKPDGTPTFSRYVEIGVD
FEAHRPVVESVSVLFELYDGDANSYAATGGPGAQLPSGWMVTAAKFEVEWPADPQRAG
LVRSHFGARRKAFNWGLAQVKADLDAKAADPAHESVDWDLKSLRWAWNRAKDDVAPWW
AENSKECYSSGLADLAQGLANWKAGKNGTRKGRRVGFPRFKSGRRDPGRVRFTTGTMR
IEDDRRTITVPVIGPLRAKENTRRVQRHLVSGRAQILNMTLSQRWGRLFVAVCYALRT
PTTRSPLTQPTVRAGMDLGVRTLATVATLDTATGEQTIIEYPNPAPLKATLVARRRAG
RELSRRIPGSHGHRAVKAKLARLDRRCVHLRREAAHQLTTELAGTYGQVVIEDLDVAA
MKRSMRRRAFRRSVSDAAMGLVAPQLAYKTAKCSGVLTVADRWFASSQIHHGCTSPDG
TPCRLQGKGRIDKHLLCPVTGEVVDRDRNAALNLRDWPDNASRGPVGTTAPSAPGPTT
TVGTGHGADTGSSGAGGASVRPRPRRAGRGEAKTQTPQGDAA"
repeat_region complement(1029345..1029360)
/note="16 bp inverted repeat, TTGAGTGTGTTTTAGT, at the
right end of IS element IS1535"
gene complement(1029513..1030577)
/locus_tag="Rv0923c"
CDS complement(1029513..1030577)
/codon_start=1
/transl_table=11
/locus_tag="Rv0923c"
/product="Conserved hypothetical protein"
/note="Rv0923c, (MTCY21C12.17c), len: 354 aa. Conserved
hypothetical protein, showing similarity with C-terminal
part of AF034138|AF034138_7|yjoB hypothetical protein from
Bacillus subtilis (200 aa), FASTA scores: opt: 193, E():
4.2e-05, (32.3% identity in 167 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0923c"
/db_xref="EnsemblGenomes-Tr:CCP43671"
/db_xref="GOA:I6XWK6"
/db_xref="InterPro:IPR008585"
/db_xref="InterPro:IPR013024"
/db_xref="InterPro:IPR017939"
/db_xref="InterPro:IPR036568"
/db_xref="InterPro:IPR038128"
/db_xref="UniProtKB/TrEMBL:I6XWK6"
/protein_id="CCP43671.1"
/translation="MPDRRHPYFAYGSNLCAHQMASRCPDAGAPRPAVLSDHNWLINQ
RGVATVEPFAGNKVHGVLWQLSERDLVRLDSAEGVPVRYRRERLTVHTDDTALPAWVY
IDHRVMPGRPRPGYLPRVIDGARHHGLPQRWIDYLHRWDPARWPLPVLPSSRSGPAPQ
SLSELLSQPGVIETSQLRSRFGFLAIHGGGLEQVTDLIAERSAEAAGASVYLLRHPDN
YPHHLPSARFDPAESARLAEFLDHVDVAVSLHGYDRIGRSTQLLAGGRNRALAAHLAR
HIQLPGYRVVTDLAAIPEELRGLHPDNPVNRVRDGGTQLELSIRVRGLGPRSTLPGVG
GMSPVTATLVQGLVTAARSW"
gene complement(1030578..1031864)
/gene="mntH"
/gene_synonym="Mramp"
/gene_synonym="Nramp"
/locus_tag="Rv0924c"
CDS complement(1030578..1031864)
/codon_start=1
/transl_table=11
/gene="mntH"
/gene_synonym="Mramp"
/gene_synonym="Nramp"
/locus_tag="Rv0924c"
/product="Divalent cation-transport integral membrane
protein MntH (BRAMP) (MRAMP)"
/note="Rv0924c, (MTCY21C12.18c), len: 428 aa. MntH
(alternative gene name: Nramp, Mramp), H+-dependent
divalent cation-transport integral membrane protein (see
citations below), equivalent to O69443|MNTH_MYCBO probable
manganese transport protein MNTH (BRAMP) from
Mycobacterium bovis (415 aa); and NP_302396.1|NC_002677
probable manganese transport protein from Mycobacterium
leprae (426 aa). Also similar (but longer 51 aa in
N-terminus) to AAA63075.1|U15184 SMF2 protein from
Mycobacterium leprae (377 aa), FASTA scores: opt: 1780,
E(): 0, (74.5% identity in 376 aa overlap). Also similar
to many orthologues of the eukaryotic Nramp (natural
resistance-associated macrophage protein), also known as
mntH, e.g. NP_456951.1|NC_003198 manganese transport
protein MntH from Salmonella enterica subsp. enterica
serovar Typhi (413 aa); etc. Belongs to the NRAMP family."
/db_xref="EnsemblGenomes-Gn:Rv0924c"
/db_xref="EnsemblGenomes-Tr:CCP43672"
/db_xref="GOA:P9WIZ5"
/db_xref="InterPro:IPR001046"
/db_xref="UniProtKB/Swiss-Prot:P9WIZ5"
/protein_id="CCP43672.1"
/translation="MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAI
AYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRSLPEAIGKR
MGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQ
DRRGQRLFERVITALLLVIAIGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIM
GATVMPHAVYLHSGLARDRHGHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVA
ALNMRGRGDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASSSVGAYAGAMIMQGL
LHWSVPMLVRRLITLGPALAILTLGFDPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPA
VMGGDTNHRATTWVGWVVAVMVSLLNVMLIYLTVTG"
gene complement(1031896..1032633)
/locus_tag="Rv0925c"
CDS complement(1031896..1032633)
/codon_start=1
/transl_table=11
/locus_tag="Rv0925c"
/product="Conserved protein"
/note="Rv0925c, (MTCY21C12.19c), len: 245 aa. Conserved
protein, similar to AL132991|SCF55_19 hypothetical protein
from Streptomyces coelicolor (197 aa), FASTA scores: opt:
459, E(): 1.2e-23, (39.3% identity in 201 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0925c"
/db_xref="EnsemblGenomes-Tr:CCP43673"
/db_xref="GOA:I6Y946"
/db_xref="InterPro:IPR005025"
/db_xref="InterPro:IPR029039"
/db_xref="UniProtKB/TrEMBL:I6Y946"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43673.1"
/translation="MTTTSDQNAAAPPRFDGLRALFINATLKRSPELSHTDGLIERSS
GIMREHGVQVDTLRAVDHDIATGVWPDMTEHGWATDEWPALYRRVLDAHILVLCGPIW
LGDNSSVMKRVIERLYACSSLLNEDGQYAYYGRAGGCLITGNEDGVKHCAMNVLYSLQ
HLGYTIPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRNTTFMTFNLMHIAQMLRVA
GGIPAYGNQRTKWDAGCRPDFANPDYR"
gene complement(1032710..1033786)
/locus_tag="Rv0926c"
CDS complement(1032710..1033786)
/codon_start=1
/transl_table=11
/locus_tag="Rv0926c"
/product="Conserved hypothetical protein"
/note="Rv0926c, (MTCY21C12.20c), len: 358 aa. Conserved
hypothetical protein, similar to Rv1059 conserved
hypothetical protein from Mycobacterium tuberculosis (354
aa). Also shows some similarity to AF170923|AF170923_3
dihydrodipicolinate reductase from Mastigocladus laminosus
(278 aa), FASTA scores: opt: 170, E(): 0.00088, (25.7%
identity in 276 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0926c"
/db_xref="EnsemblGenomes-Tr:CCP43674"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6WZS8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43674.1"
/translation="MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDA
AELAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAAGINIVG
SGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFANDLLPMALAGTCESIE
QIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLLQPGVLSLAWGSVVRQLAAGLGI
SLDGVEEMYVREPAPEAFNIASGHIPKGSAAALRFEVLGLVDGVPAVVLEHVTRLRAD
LCPEWPQPAQPGGSYRIEISGEPCYAMDICLSSRHGDHNHAGLVATAMRIVNAIPAVV
AAEPGIRTTLDLPLITGEGRYAAA"
gene complement(1033840..1034631)
/locus_tag="Rv0927c"
CDS complement(1033840..1034631)
/codon_start=1
/transl_table=11
/locus_tag="Rv0927c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv0927c, (MTCY21C12.21c), len: 263 aa. Probable
short-chain dehydrogenase/reductase, similar to various
dehydrogenases/reductases, notably 7-alpha-hydroxysteroid
dehydrogenases and glucose 1-dehydrogenases e.g.
P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase
from Escherichia coli (255 aa), FASTA scores: opt: 551,
E(): 1e-26, (39.5% identity in 248 aa overlap);
NP_252778.1|NC_002516 probable short-chain dehydrogenase
from Pseudomonas aeruginosa (253 aa); AAC44307.1|U59433
3-ketoacyl-acyl carrier protein reductase from Bacillus
subtilis (246 aa); etc. Also similar to other
dehydrogenases from Mycobacterium tuberculosis e.g.
MTCY09F9.36, E():1.4e-18; MTCY369.14, E():8e-17;
MTCY02B10.14, E():2.5e-14; MTCY09F9.23c, E():1.5e-13;
MTCY03C7.07, E():1.9e-13. Contains PS00061 Short-chain
dehydrogenases/reductases family signature, and PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv0927c"
/db_xref="EnsemblGenomes-Tr:CCP43675"
/db_xref="GOA:P9WGQ5"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGQ5"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43675.1"
/translation="MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTS
SELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNT
LLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAY
GTAKAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRR
LGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL"
gene 1034903..1036015
/gene="pstS3"
/gene_synonym="phoS2"
/locus_tag="Rv0928"
CDS 1034903..1036015
/codon_start=1
/transl_table=11
/gene="pstS3"
/gene_synonym="phoS2"
/locus_tag="Rv0928"
/product="Periplasmic phosphate-binding lipoprotein PstS3
(PBP-3) (PstS3) (PHOS1)"
/note="Rv0928, (MTCY21C12.22), len: 370 aa. PstS3
(previously known as phoS2), phosphate-binding lipoprotein
component of inorganic phosphate transport system (see
citations below), highly similar to others from
Mycobacterium leprae e.g. Q50099|PSTS3|PHOS1
phosphate-binding protein 3 precursor (328 aa), FASTA
scores: opt: 1772, E(): 0, (79.6% identity in 328 aa
overlap); and highly similar to others e.g.
AAF74819.1|AF137360_1|AF137360 periplasmic phosphate
permease from Mycobacterium avium (369 aa). Also highly
similar to Rv0932c|MTCY08D9.07|pstS2 phosphate-binding
periplasmic lipoprotein (370 aa); and Rv0934|pstS1
phosphate-binding periplasmic lipoprotein (374 aa) from
Mycobacterium tuberculosis (Mycobacterium tuberculosis
seems to have three PstS-like proteins, others being
Rv0932c and Rv0934c). Contains lipoprotein signature
(PS00013) at N-terminus. Belongs to family of phosphate
receptors for bacterial ABC-type lipoprotein
transporters."
/db_xref="EnsemblGenomes-Gn:Rv0928"
/db_xref="EnsemblGenomes-Tr:CCP43676"
/db_xref="GOA:P9WGT7"
/db_xref="InterPro:IPR005673"
/db_xref="InterPro:IPR024370"
/db_xref="PDB:4LVQ"
/db_xref="UniProtKB/Swiss-Prot:P9WGT7"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43676.1"
/translation="MKLNRFGAAVGVLAAGALVLSACGNDDNVTGGGATTGQASAKVD
CGGKKTLKASGSTAQANAMTRFVNVFEQACPGQTLNYTANGSGAGISEFNGNQTDFGG
SDVPLSKDEAAAAQRRCGSPAWNLPVVFGPIAVTYNLNSVSSLNLDGPTLAKIFNGSI
TQWNNPAIQALNRDFTLPGERIHVVFRSDESGTTDNFQRYLQAASNGAWGKGAGKSFQ
GGVGEGARGNDGTSAAAKNTPGSITYNEWSFAQAQHLTMANIVTSAGGDPVAITIDSV
GQTIAGATISGVGNDLVLDTDSFYRPKRPGSYPIVLATYEIVCSKYPDSQVGTAVKAF
LQSTIGAGQSGLGDNGYIPIPDEFKSRLSTAVNAIA"
gene 1036028..1037002
/gene="pstC2"
/locus_tag="Rv0929"
CDS 1036028..1037002
/codon_start=1
/transl_table=11
/gene="pstC2"
/locus_tag="Rv0929"
/product="Phosphate-transport integral membrane ABC
transporter PstC2"
/note="Rv0929, (MTCY21C12.23), len: 324 aa.
PstC2,phosphate-transport integral membrane ABC
transporter (see citations below), highly similar to
others e.g. NP_302394.1|NC_002677 membrane-bound component
of phosphate transport from Mycobacterium leprae (319 aa);
CAB88474.1|AL353816 phosphate ABC transport system
permease protein from Streptomyces coelicolor (336 aa);
NP_290359.1| NC_002655 high-affinity phosphate-specific
transport system (cytoplasmic membrane component) from
Escherichia coli strain O157:H7 (319 aa); etc. Also
similar to Rv935|MTCY08D9.04c|PSTC1 probable transmembrane
ABC transporter component of phosphate uptake system from
Mycobacterium tuberculosis (338 aa). Contains
binding-protein-dependent transport systems inner membrane
component signature (PS00402)."
/db_xref="EnsemblGenomes-Gn:Rv0929"
/db_xref="EnsemblGenomes-Tr:CCP43677"
/db_xref="GOA:P9WG05"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR011864"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WG05"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP43677.1"
/translation="MVTEPLTKPALVAVDMRPARRGERLFKLAASAAGSTIVIAILLI
AIFLLVRAVPSLRANHANFFTSTQFDTSDDEQLAFGVRDLFMVTALSSITALVLAVPV
AVGIAVFLTHYAPRRLSRPFGAMVDLLAAVPSIIFGLWGIFVLAPKLEPIARFLNRNL
GWLFLFKQGNVSLAGGGTIFTAGIVLSVMILPIVTSISREVFRQTPLIQIEAALALGA
TKWEVVRMTVLPYGRSGVVAASMLGLGRALGETVAVLVILRSAARPGTWSLFDGGYTF
ASKIASAASEFSEPLPTGAYISAGFALFVLTFLVNAAARAIAGGKVNG"
gene 1036999..1037925
/gene="pstA1"
/locus_tag="Rv0930"
CDS 1036999..1037925
/codon_start=1
/transl_table=11
/gene="pstA1"
/locus_tag="Rv0930"
/product="Probable phosphate-transport integral membrane
ABC transporter PstA1"
/note="Rv0930, (MTCY21C12.24), len: 308 aa. Probable
pstA1,phosphate-transport integral membrane ABC
transporter (see citation below), highly similar to others
e.g. NP_302393.1|NC_002677 membrane-bound component of
phosphate transport from Mycobacterium leprae (304 aa);
CAB88473.1|AL353816 phosphate ABC transport system
permease protein from Streptomyces coelicolor (354 aa)
(N-terminus longer); NP_312689.1|NC_002695 phosphate
transport system permease protein PstA from Escherichia
coli strain O157:H7 (296 aa); etc. Also similar to
Rv0936|MTCY08D9.03c|PSTA2 probable transmembrane ABC
transporter component of phosphate uptake system from
Mycobacterium tuberculosis (301 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0930"
/db_xref="EnsemblGenomes-Tr:CCP43678"
/db_xref="GOA:P9WG11"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR005672"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WG11"
/protein_id="CCP43678.1"
/translation="MSPSMSIEALDQPVKPVVFRPLTLRRRIKNSVATTFFFTSFVVA
LIPLVWLLWVVIARGWFAVTRSGWWTHSLRGVLPEQFAGGVYHALYGTLVQAGVAAVL
AVPLGLMTAVYLVEYGTGRMSRVTTFTVDVLAGVPSIVAALFVFSLWIATLGFQQSAF
AVALALVLLMLPVVVRAGEEMLRLVPDELREASYALGVPKWKTIVRIVAPIAMPGIVS
GILLSIARVVGETAPVLVLVGYSHSINLDVFHGNMASLPLLIYTELTNPEHAGFLRVW
GAALTLIIVVATINLAAAMIRFVATRRRRLPL"
gene complement(1037920..1039914)
/gene="pknD"
/gene_synonym="mbk"
/locus_tag="Rv0931c"
CDS complement(1037920..1039914)
/codon_start=1
/transl_table=11
/gene="pknD"
/gene_synonym="mbk"
/locus_tag="Rv0931c"
/product="Transmembrane serine/threonine-protein kinase D
PknD (protein kinase D) (STPK D)"
/note="Rv0931c, (MTCY08D9.08), len: 664 aa. PknD
(alternate gene name: mbk), transmembrane serine/threonine
protein kinase (see citations below), equivalent to
CAB62227.1|AJ250200 putative serine/threonine protein
kinase from Mycobacterium bovis BCG (291 aa); and highly
similar in N-terminus to P54744|PKNB_MYCLE probable
serine/threonine-specific protein kinase from
Mycobacterium leprae (622 aa). Also highly similar to
others,particularly in N-terminal half e.g.
NP_243370.1|NC_002570 serine/threonine protein kinase from
Bacillus halodurans (664 aa); NP_268044.1|NC_002662
serine/threonine protein kinase from Lactococcus lactis
(627 aa); etc. Also highly similar to other
serine/threonine protein kinases from Mycobacterium
tuberculosis e.g. pknH (626 aa), FASTA scores: opt: 1398,
E: 0, (49.3% identity in 540 aa overlap); pknE (566 aa);
pknB (626 aa); Rv3524 (343 aa); etc. Contains Hank's
kinase subdomain. Contains two transmembrane segments,
which flank a highly repetitive region, suggesting a
receptor-like anchoring. Belongs to the Ser/Thr family of
protein kinases. Experimental studies show evidence of
auto-phosphorylation on a serine residue. Appears to be
co-transcribed with Rv0932c|pstS2."
/db_xref="EnsemblGenomes-Gn:Rv0931c"
/db_xref="EnsemblGenomes-Tr:CCP43679"
/db_xref="GOA:P9WI79"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001258"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR011042"
/db_xref="InterPro:IPR013017"
/db_xref="InterPro:IPR013658"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR035016"
/db_xref="PDB:1RWI"
/db_xref="PDB:1RWL"
/db_xref="UniProtKB/Swiss-Prot:P9WI79"
/inference="protein motif:PROSITE:PS00108"
/inference="protein motif:PROSITE:PS00107"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43679.1"
/translation="MSDAVPQVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALK
LISPQYSDNAVFRARMQREADTAGRLTEPHIVPIHDYGEINGQFFVEMRMIDGTSLRA
LLKQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILVTASDFAYLVDFGIA
RAASDPGLTQTGTAVGTYNYMAPERFTGDEVTYRADIYALACVLGECLTGAPPYRADS
VERLIAAHLMDPAPQPSQLRPGRVPPALDQVIAKGMAKNPAERFMSAGDLAIAAHDAL
TTSEQHQATTILRRGDNATLLATPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSAT
VAGPLAADSRGGNWPSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVA
IVAAAGYLVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRV
VKLATGSTGTTVLPFNGLYQPQGLAVDGAGTVYVTDFNNRVVTLAAGSNNQTVLPFDG
LNYPEGLAVDTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVY
VTDTDNNRVVKLEAESNNQVVLPFTDITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGS
TTSTVLPFTGLNTPLAVAVDSDRTVYVADRGNDRVVKLTS"
gene complement(1039936..1041048)
/gene="pstS2"
/locus_tag="Rv0932c"
CDS complement(1039936..1041048)
/codon_start=1
/transl_table=11
/gene="pstS2"
/locus_tag="Rv0932c"
/product="Periplasmic phosphate-binding lipoprotein PstS2
(PBP-2) (PstS2)"
/note="Rv0932c, (MTCY08D9.07), len: 370 aa.
PstS2,phosphate-binding lipoprotein component of inorganic
phosphate transport system (see citations below), highly
similar to AAF74819.1|AF137360_1|AF137360 periplasmic
phosphate permease from Mycobacterium avium (369 aa);
Rv0928|MTCY21C12.22|pstS3 phosphate-binding periplasmic
lipoprotein from Mycobacterium tuberculosis (370 aa),
FASTA scores: opt: 1601, E(): 0, (64.5% identity in 372 aa
overlap); and Rv0934|MTCY08D9.05c|pstS1 phosphate-binding
periplasmic lipoprotein from Mycobacterium tuberculosis
(374 aa) (Mycobacterium tuberculosis seems to have three
PstS-like proteins, others being Rv0928 and Rv0934c). Also
highly similar to MTCY08D9.05c|P15712|PAB_MYCTU protein
antigen B precursor from Mycobacterium tuberculosis (374
aa), FASTA scores: opt: 460, E(): 2.7e-20, (31.2% identity
in 375 aa overlap). Contains prokaryotic membrane
lipoprotein lipid attachment site (PS00013) at N-terminus
so the leader peptide of 22 aa is probably removed.
Belongs to family of phosphate receptors for bacterial
ABC-type lipoprotein transporters. Appears to be
co-transcribed with Rv0931c|pknD|mbk."
/db_xref="EnsemblGenomes-Gn:Rv0932c"
/db_xref="EnsemblGenomes-Tr:CCP43680"
/db_xref="GOA:P9WGT9"
/db_xref="InterPro:IPR005673"
/db_xref="InterPro:IPR024370"
/db_xref="UniProtKB/Swiss-Prot:P9WGT9"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43680.1"
/translation="MKFARSGAAVSLLAAGTLVLTACGGGTNSSSSGAGGTSGSVHCG
GKKELHSSGSTAQENAMEQFVYAYVRSCPGYTLDYNANGSGAGVTQFLNNETDFAGSD
VPLNPSTGQPDRSAERCGSPAWDLPTVFGPIAITYNIKGVSTLNLDGPTTAKIFNGTI
TVWNDPQIQALNSGTDLPPTPISVIFRSDKSGTSDNFQKYLDGASNGAWGKGASETFN
GGVGVGASGNNGTSALLQTTDGSITYNEWSFAVGKQLNMAQIITSAGPDPVAITTESV
GKTIAGAKIMGQGNDLVLDTSSFYRPTQPGSYPIVLATYEIVCSKYPDATTGTAVRAF
MQAAIGPGQEGLDQYGSIPLPKSFQAKLAAAVNAIS"
gene 1041264..1042094
/gene="pstB"
/locus_tag="Rv0933"
CDS 1041264..1042094
/codon_start=1
/transl_table=11
/gene="pstB"
/locus_tag="Rv0933"
/product="Phosphate-transport ATP-binding protein ABC
transporter PstB"
/note="Rv0933, (MTCY08D9.06c), len: 276 aa.
PstB,phosphate-transport ATP-binding protein ABC
transporter (see citations below), thermostable ATPase,
highly similar to others e.g. NP_348334.1|NC_003030 ATPase
component of ABC-type phosphate transport system from
Clostridium acetobutylicum (249 aa); NP_212352.1|NC_001318
phosphate ABC transporter ATP-binding protein (pstB) from
Borrelia burgdorferi (260 aa); NP_390375.1|NC_000964
phosphate ABC transporter (ATP-binding protein) from
Bacillus subtilis (269 aa), FASTA scores: opt: 762, E():
0, (47.7% identity in 243 aa overlap); etc. Also similar
to other M. tuberculosis ABC transporters e.g. MTCY253.24,
E(): 2.5e-15 and MTCY359.14c, E(): 3.4e-15. Contains
PS00211 ABC transporters family signature, and PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
ATP-binding transport protein family (ABC transporters).
Magnesium or calcium seem to have no influence on the
functionality of this enzyme."
/db_xref="EnsemblGenomes-Gn:Rv0933"
/db_xref="EnsemblGenomes-Tr:CCP43681"
/db_xref="GOA:P9WQK9"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005670"
/db_xref="InterPro:IPR015850"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQK9"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43681.1"
/translation="MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGF
PARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRR
VGMLFQRPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDS
PFRLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIV
THNLAQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN
"
gene 1042115..1043239
/gene="pstS1"
/gene_synonym="phoS"
/gene_synonym="phoS1"
/locus_tag="Rv0934"
CDS 1042115..1043239
/codon_start=1
/transl_table=11
/gene="pstS1"
/gene_synonym="phoS"
/gene_synonym="phoS1"
/locus_tag="Rv0934"
/product="Periplasmic phosphate-binding lipoprotein PstS1
(PBP-1) (PstS1)"
/note="Rv0934, (MTCY08D9.05c), len: 374 aa. PstS1
(previously known as phoS1 or phoS), phosphate-binding
lipoprotein component of inorganic phosphate transport
system (see citations below), highly similar to
Rv0932c|MTCY08D9.07|pstS2 phosphate-binding periplasmic
lipoprotein from Mycobacterium tuberculosis (370 aa),
FASTA scores: opt: 460, E(): 5.9e-19, (31.2% identity in
375 aa overlap); and Rv0928|MTCY21C12.22|pstS3
phosphate-binding periplasmic lipoprotein from
Mycobacterium tuberculosis (374 aa), FASTA scores: opt:
435, E():1.1e-17, (30.0% identity in 380 aa overlap)
(Mycobacterium tuberculosis seems to have three PstS-like
proteins, others being Rv0932c and Rv0928c). Also highly
similar to MTCY08D9.05c|P15712|PAB_MYCTU protein antigen B
precursor from Mycobacterium tuberculosis (374 aa), FASTA
scores: opt: 2459, E(): 0, (100% identity in 374 aa
overlap). Contains a prokaryotic membrane lipoprotein
lipid attachment site (PS00013) at the N-terminus so the
23 aa leader peptide sequence is probably removed. Belongs
to family of phosphate receptors for bacterial ABC-type
lipoprotein transporters."
/db_xref="EnsemblGenomes-Gn:Rv0934"
/db_xref="EnsemblGenomes-Tr:CCP43682"
/db_xref="GOA:P9WGU1"
/db_xref="InterPro:IPR005673"
/db_xref="InterPro:IPR024370"
/db_xref="PDB:1PC3"
/db_xref="UniProtKB/Swiss-Prot:P9WGU1"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43682.1"
/translation="MKIRLHTLLAVLTAAPLLLAAAGCGSKPPSGSPETGAGAGTVAT
TPASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNI
GASDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKT
WDDPQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVD
FPAVPGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLP
DAQSIQAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQA
FLHWAITDGNKASFLDQVHFQPLPPAVVKLSDALIATISS"
gene 1043299..1044315
/gene="pstC1"
/locus_tag="Rv0935"
CDS 1043299..1044315
/codon_start=1
/transl_table=11
/gene="pstC1"
/locus_tag="Rv0935"
/product="Phosphate-transport integral membrane ABC
transporter PstC1"
/note="Rv0935, (MTCY08D9.04c), len: 338 aa.
PstC1,phosphate-transport integral membrane ABC
transporter (see citations below), highly similar to
others e.g. NP_104768.1|NC_002678|pstC phosphate ABC
transporter permease protein from Mesorhizobium loti (327
aa); NP_245372.1|NC_002663|PstC PstC protein from
Pasteurella multocida (320 aa); P45191|PSTC_HAEIN
phosphate transport system permease from Haemophilus
influenza (315 aa), FASTA scores: opt: 667, E(): 0, (36.2%
identity in 309 aa overlap); etc. Also similar to
Rv0929|MTCY21C12.23|PSTC2 probable transmembrane ABC
transporter component of phosphate uptake system from
Mycobacterium tuberculosis (324 aa), FASTA scores: opt:
487, E(): 4.1e-21, (32.3% identity in 303 aa overlap); and
shows slight similarity to MTCY08D9.03c|PSTA2|Rv0936
probable transmembrane ABC transporter component of
phosphate uptake system from Mycobacterium tuberculosis
(301 aa). Contains binding-protein-dependent transport
systems inner membrane comp signature (PS00402)."
/db_xref="EnsemblGenomes-Gn:Rv0935"
/db_xref="EnsemblGenomes-Tr:CCP43683"
/db_xref="GOA:P9WG07"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR011864"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WG07"
/inference="protein motif:PROSITE:PS00402"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43683.1"
/translation="MLARAGEVGRAGPAIRWLGGIGAVIPLLALVLVLVVLVIEAMGA
IRLNGLHFFTATEWNPGNTYGETVVTDGVAHPVGAYYGALPLIVGTLATSAIALIIAV
PVSVGAALVIVERLPKRLAEAVGIVLELLAGIPSVVVGLWGAMTFGPFIAHHIAPVIA
HNAPDVPVLNYLRGDPGNGEGMLVSGLVLAVMVVPIIATTTHDLFRQVPVLPREGAIA
LGMSNWECVRRVTLPWVSSGIVGAVVLGLGRALGETMAVAMVSGAVLGAMPANIYATM
TTIAATIVSQLDSAMTDSTNFAVKTLAEVGLVLMVITLLTNVAARGMVRRVSRTALPV
GRGI"
gene 1044317..1045222
/gene="pstA2"
/locus_tag="Rv0936"
CDS 1044317..1045222
/codon_start=1
/transl_table=11
/gene="pstA2"
/locus_tag="Rv0936"
/product="Phosphate-transport integral membrane ABC
transporter PstA2"
/note="Rv0936, (MTCY08D9.03c), len: 301 aa.
PstA2,phosphate-transport integral membrane ABC
transporter (see citations below), highly similar to
others e.g. NP_442269.1|NC_000911|PstA phosphate transport
system permease protein from Synechocystis sp. strain PCC
6803 (287 aa); NP_232473.1|NC_002506 phosphate ABC
transporter permease protein from Vibrio cholerae (289
aa); P07654|PSTA_ECOLI phosphate transport system permease
from Escherichia coli (296 aa), FASTA scores: opt: 464,
E(): 6.7e-24, (30.5% identity in 282 aa overlap); etc.
Also similar to O86345|MTCY21C12.24|PSTA1|Rv0930 probable
transmembrane ABC transporter component of phosphate
uptake system from Mycobacterium tuberculosis (304 aa),
FASTA scores: opt: 369, E(): 6.1e-15, (32.7% identity in
248 aa overlap). Contains binding-protein-dependent
transport systems inner membrane comp signature
(PS00402)."
/db_xref="EnsemblGenomes-Gn:Rv0936"
/db_xref="EnsemblGenomes-Tr:CCP43684"
/db_xref="GOA:P9WG09"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR005672"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WG09"
/inference="protein motif:PROSITE:PS00402"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43684.1"
/translation="MGESAESGSRQLPAMSPPRRSVAYRRKIVDALWWAACVCCLAVV
ITPTLWMLIGVVSRAVPVFHWSVLVQDSQGNGGGLRNAIIGTAVLAIGVILVGGTVSV
LTGIYLSEFATGKTRSILRGAYEVLSGIPSIVLGYVGYLALVVYFDWGFSLAAGVLVL
SVMSIPYIAKATESALAQVPTSYREAAEALGLPAGWALRKIVLKTAMPGIVTGMLVAL
ALAIGETAPLLYTAGWSNSPPTGQLTDSPVGYLTYPIWTFYNQPSKSAQDLSYDAALL
LIVFLLLLIFIGRLINWLSRRRWDV"
gene complement(1045199..1046020)
/gene="mku"
/locus_tag="Rv0937c"
CDS complement(1045199..1046020)
/codon_start=1
/transl_table=11
/gene="mku"
/locus_tag="Rv0937c"
/product="DNA end-binding protein, Mku"
/note="Rv0937c, (MTCY08D9.02), len: 273 aa. Mku, DNA
end-binding protein, highly similar to others e.g.
SC6G9.24c|T35620|AL079356 hypothetical protein from
Streptomyces coelicolor (365 aa), FASTA scores: opt:
648,E(): 0, (36.5% identity in 274 aa overlap);
Z99110|BSUB0007_223|NP_389224.1|NC_000964 hypothetical
proteins from Bacillus subtilis (311 aa), FASTA scores:
opt: 623, E(): 1.1e-31, (33.9% identity in 274 aa
overlap); O28548|AE000984|AF1726|NP_070554.1|NC_000917
conserved hypothetical protein from Archaeoglobus fulgidus
(286 aa),FASTA scores: opt: 583, E(): 0, (36.6% identity
in 262 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0937c"
/db_xref="EnsemblGenomes-Tr:CCP43685"
/db_xref="GOA:P9WKD9"
/db_xref="InterPro:IPR006164"
/db_xref="InterPro:IPR009187"
/db_xref="InterPro:IPR016194"
/db_xref="UniProtKB/Swiss-Prot:P9WKD9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43685.1"
/translation="MRAIWTGSIAFGLVNVPVKVYSATADHDIRFHQVHAKDNGRIRY
KRVCEACGEVVDYRDLARAYESGDGQMVAITDDDIASLPEERSREIEVLEFVPAADVD
PMMFDRSYFLEPDSKSSKSYVLLAKTLAETDRMAIVHFTLRNKTRLAALRVKDFGKRE
VMMVHTLLWPDEIRDPDFPVLDQKVEIKPAELKMAGQVVDSMADDFNPDRYHDTYQEQ
LQELIDTKLEGGQAFTAEDQPRLLDEPEDVSDLLAKLEASVKARSKANSNVPTPP"
gene 1046136..1048415
/gene="ligD"
/locus_tag="Rv0938"
CDS 1046136..1048415
/codon_start=1
/transl_table=11
/gene="ligD"
/locus_tag="Rv0938"
/product="ATP dependent DNA ligase LigD (ATP dependent
polydeoxyribonucleotide synthase) (thermostable DNA
ligase) (ATP dependent polynucleotide ligase) (sealase)
(DNA repair enzyme) (DNA joinase)"
/note="Rv0938, (MTCY08D9.01c, MTCY10D7.36c), len: 759 aa.
ligD, ATP-dependent DNA ligase, with its C-terminus
similar to N-terminal parts of many ATP-dependent DNA
ligases e.g. NP_250828.1|NC_002516 probable ATP-dependent
DNA ligase from Pseudomonas aeruginosa (840 aa);
NP_105436.1|NC_002678 ATP-dependent DNA ligase from
Mesorhizobium loti (829 aa); CAB92891.1|AL356932 probable
ATP-dependent DNA ligase from Streptomyces coelicolor (326
aa); etc. The N-terminal half shows similarity with
hypothetical proteins from Mycobacterium tuberculosis
Rv0269c and Rv3730c; and the C-terminal half with the DNA
ligases Rv3731 and Rv3062."
/db_xref="EnsemblGenomes-Gn:Rv0938"
/db_xref="EnsemblGenomes-Tr:CCP43686"
/db_xref="GOA:P9WNV3"
/db_xref="InterPro:IPR012309"
/db_xref="InterPro:IPR012310"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR014144"
/db_xref="InterPro:IPR014145"
/db_xref="InterPro:IPR014146"
/db_xref="InterPro:IPR033649"
/db_xref="PDB:1VS0"
/db_xref="PDB:2IRU"
/db_xref="PDB:2IRX"
/db_xref="PDB:2IRY"
/db_xref="PDB:2R9L"
/db_xref="PDB:3PKY"
/db_xref="PDB:4MKY"
/db_xref="UniProtKB/Swiss-Prot:P9WNV3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43686.1"
/translation="MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHI
AGRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWI
AQQAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLL
ADIGLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKS
LRAGKVFVDWSQNSGSKTTIAPYSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTR
IARDGDLLERLDADAPVADRLTRYRRMRDASKTPEPIPTAKPVTGDGNTFVIQEHHAR
RPHYDFRLECDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAG
KVIIWDSGTYDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQ
KVFEFDNLAPMLATHGTVAGLKASQWAFEGKWDGYRLLVEADHGAVRLRSRSGRDVTA
EYPQLRALAEDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFDLLYLDG
RALLGTRYQDRRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRY
QPGRRCASWVKDKHWNTQEVVIGGWRAGEGGRSSGVGSLLMGIPGPGGLQFAGRVGTG
LSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYVKPALVAEVRYSEWTPEGRLR
QSSWRGLRPDKKPSEVVRE"
gene 1048412..1050346
/locus_tag="Rv0939"
CDS 1048412..1050346
/codon_start=1
/transl_table=11
/locus_tag="Rv0939"
/product="Possible bifunctional enzyme:
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD
isomerase) + cyclase/dehydrase"
/note="Rv0939, (MTCY10D7.35c), len: 644 aa. Possible
bifunctional enzyme, including
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase activity,
and cyclase/dehydrase activity. N-terminal part similar to
many isomerases e.g. NP_343861.1|NC_002754
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1)
from Sulfolobus solfataricus (318 aa);
NP_068932.1|NC_000917 2-hydroxyhepta-2,4-diene-1,7-dioate
isomerase (hpcE-1) from Archaeoglobus fulgidus (324 aa),
FASTA scores: opt: 400,E(): 5.8e-15, (33.9% identity in
289 aa overlap); etc. And C-terminal part highly similar
to many cyclases/dehydrases e.g. AAK61721.1|AY033994
cyclase-like protein from Streptomyces aureofaciens (305
aa); CAC44204.1|AL593842 cyclase from Streptomyces
coelicolor (297 aa), FASTA scores: opt: 375, E(): 2.7e-26,
(35.6% identity in 284 aa overlap); NP_343860.1|NC_002754
putative Cyclase/dehydrase from Sulfolobus solfataricus
(308 aa); etc. Also similar to Rv2993c hypothetical
protein from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv0939"
/db_xref="EnsemblGenomes-Tr:CCP43687"
/db_xref="GOA:O86346"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR011234"
/db_xref="InterPro:IPR036663"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:O86346"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43687.1"
/translation="MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRT
AGERAVRSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDTWY
RIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGY
TIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIAL
VNGTVIGSGSTAQMDWSFGEVIAYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFP
GWLHDGDVVTLQVEGLGETRQTVRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTR
GLHEVADRVWAWTLPDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTER
APITDALITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLGPV
ATRYLRDRFGHFDFSGIKLRNADLTFDRDLAIELGGRRVDLLNLGPAHTTADSVVHVA
DAGVLFAGDLLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVTGPDGIRAV
RGYLAHIAEQAEAAYRKGLSLPEAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTP
RQDLLALLVMQAEWAARHCT"
gene complement(1050593..1051459)
/locus_tag="Rv0940c"
CDS complement(1050593..1051459)
/codon_start=1
/transl_table=11
/locus_tag="Rv0940c"
/product="Possible oxidoreductase"
/note="Rv0940c, (MTCY10D7.34), len: 288 aa. Possible
oxidoreductase, similar to hypothetical proteins and
oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606
putative F420-dependent dehydrogenase from Rhodococcus
erythropolis (295 aa); AAG52987.1|AF040570|Rif17 putative
alkanal monooxygenase from Amycolatopsis mediterranei (356
aa); etc. Also similar to putative oxidoreductases from
Mycobacterium tuberculosis such as
Rv0953c|P71557|YT21_MYCTU (282 aa), FASTA scores: opt:
311,E(): 3.7e-08, (31.0% identity in 248 aa overlap),
Rv3079c (275 aa), Rv0791c (347 aa), etc."
/db_xref="EnsemblGenomes-Gn:Rv0940c"
/db_xref="EnsemblGenomes-Tr:CCP43688"
/db_xref="GOA:P9WKP1"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019921"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/Swiss-Prot:P9WKP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43688.1"
/translation="MRFSYAEAMTDFTFYIPLAKAAEAAGYSSMTIPDSIAYPFESDS
KYPYTPDGNREFMDGKPFIETFVLTAALGAVTTRLRFNFFVLKLPIRPPALVAKQAGS
LAALIGNRVGLGVGTSPWPEDYELMGVPFAKRGKRIDECIEIVRGLTTGDYFEFHGEF
YDIPKTKMTPAPTQPIPILVGGHADAALRRAARADGWMHGGGDPDELDRLIARVKRLR
EEAGKTSPFEIHVISLDGFTVDGVKRLEDKGVTDVIVGFRVPYTMGPDTEPLQTKIRN
LEMFAENVIAKV"
gene complement(1051544..1052317)
/locus_tag="Rv0941c"
CDS complement(1051544..1052317)
/codon_start=1
/transl_table=11
/locus_tag="Rv0941c"
/product="Conserved hypothetical protein"
/note="Rv0941c, (MTCY10D7.33), len: 257 aa. Conserved
hypothetical protein, showing some similarity with parts
of several hypothetical proteins from Streptomyces
coelicolor e.g. AL035161|SC9C7_20 (860 aa), FASTA scores:
opt: 197,E(): 2.6e-05, (34.2% identity in 114 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0941c"
/db_xref="EnsemblGenomes-Tr:CCP43689"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR036513"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/TrEMBL:P71568"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43689.1"
/translation="MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDS
LTRATLEQPSAVIVNVTELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAV
TRTGVARFMPVYPTEKAASKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQW
SRPGLIPVALVVVNVFVENVLKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPP
KGIDVSGLAIVAALSRAWGSSPTSSGKTVWAIIGPENQL"
gene 1052360..1052638
/locus_tag="Rv0942"
CDS 1052360..1052638
/codon_start=1
/transl_table=11
/locus_tag="Rv0942"
/product="Hypothetical protein"
/note="Rv0942, (MTCY10D7.32c), len: 92 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0942"
/db_xref="EnsemblGenomes-Tr:CCP43690"
/db_xref="UniProtKB/Swiss-Prot:P9WKN9"
/protein_id="CCP43690.1"
/translation="MGRSATIAMVPKRRDAMNRHSGPILSSGFIASSSNSCPANSLRM
PSALAAETLSFDDRAVRRSTHHPGGGYPQKHAINLQSGLCPAYANASR"
gene complement(1052696..1053736)
/locus_tag="Rv0943c"
CDS complement(1052696..1053736)
/codon_start=1
/transl_table=11
/locus_tag="Rv0943c"
/product="Probable monooxygenase"
/note="Rv0943c, (MTCY10D7.31), len: 346 aa. Possible
monooxygenase, similar in part to others e.g.
NP_250229.1|NC_002516 probable flavin-containing
monooxygenase from Pseudomonas aeruginosa (527 aa);
AAC36351.1|AF090329 cyclohexanone monooxygenase homolog
from Pseudomonas fluorescens (437 aa); CAB59668.1|AL132674
monooxygenase from Streptomyces coelicolor (519 aa); etc.
Also similar to putative monooxygenases from Mycobacterium
tuberculosis e.g. Rv1393c|P71662|CY21B4.10C (492 aa).
FASTA scores: opt: 129, E(): 8.5e-21, (27.5% identity in
236 aa overlap); Rv0892 (495 aa); Rv3049c (524 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0943c"
/db_xref="EnsemblGenomes-Tr:CCP43691"
/db_xref="GOA:P9WKN7"
/db_xref="InterPro:IPR032371"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WKN7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43691.1"
/translation="MAGVSEAERRGHRKLVRFQARRAIGPIRPTSAAWDRDFDPAGKR
IAVVGTDAAAAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHP
AVAWATAAIDALTSSGIRTSDGVEHPVDAIIYGTGFAIADQVGDQTLVGAGGVTIRQA
WDDGMEPYLGVAVHGFPNYFFITGPDTAAQARCVVECMKLMERTASRRIEVRRSSQQV
FNERAQLKPAQPHRQTGGLEAFDLSSAATEDDQTYDGAATLTLAGARFRVRVRLTGHL
DPIDGNYHWQGTVFDSLPETSLTHARAATLTIGGRSAPARITEQTPWGTHSVAGVGPP
PYARSGPASATT"
gene 1053765..1054241
/locus_tag="Rv0944"
CDS 1053765..1054241
/codon_start=1
/transl_table=11
/locus_tag="Rv0944"
/product="Possible formamidopyrimidine-DNA glycosylase
(FAPY-DNA glycosylase)"
/note="Rv0944, (MTCY10D7.30c), len: 158 aa. Possible
formamidopyrimidine-DNA glycosylase, similar to C-terminus
of formamidopyrimidine-DNA glycosylases e.g.
CAB63194.1|AL133469 putative formamidopyrimidine-DNA
glycosylase from Streptomyces coelicolor (287 aa);
FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA
glycosylase from Lactococcus lactis subsp. lactis (273
aa),FASTA scores: opt: 246, E(): 2.4e-09, (28.9% identity
in 142 aa overlap); O50606|FPG_THETH|MUTM|FPG
formamidopyrimidine-DNA glycosylase from Thermus
thermophilus (267 aa); etc. Also similar to C-termini of
endonucleases or DNA glycosylases of Mycobacterium
tuberculosis e.g. Rv3297, Rv2464c, Rv2924c. May belong to
the FPG family."
/db_xref="EnsemblGenomes-Gn:Rv0944"
/db_xref="EnsemblGenomes-Tr:CCP43692"
/db_xref="GOA:L0T864"
/db_xref="InterPro:IPR000214"
/db_xref="InterPro:IPR010663"
/db_xref="InterPro:IPR010979"
/db_xref="InterPro:IPR015886"
/db_xref="UniProtKB/Swiss-Prot:L0T864"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43692.1"
/translation="MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIA
GIGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKG
EKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK"
gene 1054247..1055008
/locus_tag="Rv0945"
CDS 1054247..1055008
/codon_start=1
/transl_table=11
/locus_tag="Rv0945"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv0945, (MTCY10D7.29c), len: 253 aa. Probable
short-chain dehydrogenase/reductase, similar to various
dehydrogenases/reductases e.g. NP_346338.1|NC_003028
oxidoreductase (short chain dehydrogenase/reductase
family) from Streptococcus pneumoniae (253 aa);
AAB70845.1|AF019986|PksB from Dictyostelium discoideum
(260 aa); AAF86624.1|U87786 clavaldehyde dehydrogenase
from Streptomyces clavuligerus (247 aa); P37440|UCPA_ECOLI
oxidoreductase from Escherichia coli (285 aa), FASTA
scores: opt: 275, E(): 1.1e-12, (33.8% identity in 201 aa
overlap); etc. Contains PS00061 Short-chain
dehydrogenases/reductases family signature. Belongs to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv0945"
/db_xref="EnsemblGenomes-Tr:CCP43693"
/db_xref="GOA:P9WGR7"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGR7"
/inference="protein motif:PROSITE:PS00061"
/protein_id="CCP43693.1"
/translation="MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRL
TELKAELSQRYPDIKIAVAELDVNDHERVPKVFAELSDEIGGIDRVIVNAGIGKGARL
GSGKLWANKATIETNLVAALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYA
ASKAGVRSLGESLRAEYAQRPIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVA
AIEREPGRAAVPWWPWAPLVRLMWVLPPRLTRRFA"
gene complement(1055024..1056685)
/gene="pgi"
/locus_tag="Rv0946c"
CDS complement(1055024..1056685)
/codon_start=1
/transl_table=11
/gene="pgi"
/locus_tag="Rv0946c"
/product="Probable glucose-6-phosphate isomerase Pgi (GPI)
(phosphoglucose isomerase) (phosphohexose isomerase)
(phi)"
/note="Rv0946c, (MTCY10D7.28), len: 553 aa. Probable
pgi,glucose-6-phosphate isomerase, equivalent to
NP_301236.1|NC_002677 glucose-6-phosphate isomerase from
Mycobacterium leprae (554 aa); and P96803|G6PI_MYCSM
glucose-6-phosphate isomerase from Mycobacterium smegmatis
(442 aa). Also highly similar to others e.g. T36015
glucose-6-phosphate isomerase from Streptomyces coelicolor
(551 aa); P11537|G6PI_ECOLI|GPI glucose-6-phosphate
isomerase from Escherichia coli strains K12 and O157:H7
(549 aa), FASTA scores: opt: 1779, E(): 0, (51.4% identity
in 554 aa overlap); etc. Contains PS00765 Phosphoglucose
isomerase signature 1, and PS00174 Phosphoglucose
isomerase signature 2. Belongs to the GPI family."
/db_xref="EnsemblGenomes-Gn:Rv0946c"
/db_xref="EnsemblGenomes-Tr:CCP43694"
/db_xref="GOA:P9WN69"
/db_xref="InterPro:IPR001672"
/db_xref="InterPro:IPR018189"
/db_xref="InterPro:IPR023096"
/db_xref="InterPro:IPR035476"
/db_xref="InterPro:IPR035482"
/db_xref="PDB:2WU8"
/db_xref="UniProtKB/Swiss-Prot:P9WN69"
/inference="protein motif:PROSITE:PS00174"
/inference="protein motif:PROSITE:PS00765"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43694.1"
/translation="MTSAPIPDITATPAWDALRRHHDQIGNTHLRQFFADDPGRGREL
TVSVGDLYIDYSKHRVTRETLALLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTA
LRLPRDAELVVDGQDVVTDVHAVLDAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGS
DLGPVMVYQALRHYADAGISARFVSNVDPADLIATLADLDPATTLFIVASKTFSTLET
LTNATAARRWLTDALGDAAVSRHFVAVSTNKRLVDDFGINTDNMFGFWDWVGGRYSVD
SAIGLSLMTVIGRDAFADFLAGFHIIDRHFATAPLESNAPVLLGLIGLWYSNFFGAQS
RTVLPYSNDLSRFPAYLQQLTMESNGKSTRADGSPVSADTGEIFWGEPGTNGQHAFYQ
LLHQGTRLVPADFIGFAQPLDDLPTAEGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAA
DGTPAHVVAHKVMPGNRPSTSILASRLTPSVLGQLIALYEHQVFTEGVVWGIDSFDQW
GVELGKTQAKALLPVITGAGSPPPQSDSSTDGLVRRYRTERGRAG"
gene complement(1057300..1057530)
/pseudo
/locus_tag="Rv0947c"
CDS complement(1057300..1057530)
/codon_start=1
/transl_table=11
/locus_tag="Rv0947c"
/product="Probable mycolyl transferase, pseudogene"
/note="Rv0947c, (MTCY10D7.27), len: 76 aa. Probable
mycolyl transferase pseudogene, similar to part of
P31953|A85C_MYCTU|fbpC2 antigen 85-c precursor (85c)
(fibronectin-binding protein C) from Mycobacterium
tuberculosis (340 aa), FASTA scores: opt: 213, E():
2e-08,(69.6% identity in 46 aa overlap)."
/db_xref="PSEUDO:CCP43695.1"
/pseudogene="unknown"
gene complement(1057646..1057963)
/locus_tag="Rv0948c"
CDS complement(1057646..1057963)
/codon_start=1
/transl_table=11
/locus_tag="Rv0948c"
/product="Chorismate mutase"
/note="Rv0948c, (MTCY10D7.26), len: 105 aa. Chorismate
mutase, AroQ class (See Prakash et al., 2005; Schneider et
al., 2008), equivalent to NP_301237.1|NC_002677 conserved
hypothetical protein from Mycobacterium leprae (105 aa).
Also similar (except in N-terminus) to
SCD63.16c|CAB82023.1|AL161755 hypothetical protein from
Streptomyces coelicolor (110 aa); and to N-terminus of two
chorismate mutase/prephenate dehydratase."
/db_xref="EnsemblGenomes-Gn:Rv0948c"
/db_xref="EnsemblGenomes-Tr:CCP43696"
/db_xref="GOA:P9WIC1"
/db_xref="InterPro:IPR002701"
/db_xref="InterPro:IPR010958"
/db_xref="InterPro:IPR036263"
/db_xref="InterPro:IPR036979"
/db_xref="PDB:2QBV"
/db_xref="PDB:2VKL"
/db_xref="PDB:2W19"
/db_xref="PDB:2W1A"
/db_xref="PDB:5CKX"
/db_xref="PDB:5MPV"
/db_xref="UniProtKB/Swiss-Prot:P9WIC1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43696.1"
/translation="MRPEPPHHENAELAAMNLEMLESQPVPEIDTLREEIDRLDAEIL
ALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGR
LGH"
gene 1058260..1060575
/gene="uvrD1"
/gene_synonym="uvrD"
/locus_tag="Rv0949"
CDS 1058260..1060575
/codon_start=1
/transl_table=11
/gene="uvrD1"
/gene_synonym="uvrD"
/locus_tag="Rv0949"
/product="Probable ATP-dependent DNA helicase II UvrD1"
/note="Rv0949, (MTCY10D7.25c), len: 771 aa. Probable
uvrD1,ATP dependent DNA helicase II (see citation
below),equivalent to P_301239.1|NC_002677 putative
ATP-dependent DNA helicase from Mycobacterium leprae (778
aa). Also highly similar to others e.g.
CAB92660.1|AL356832 from Streptomyces coelicolor (831 aa)
(N-terminus longer); P56255|PCRA_BACST from Bacillus
stearothermophilus (724 aa); Q10213|YAY5_SCHPO from
Schizosaccharomyces pombe (Fission yeast) (887 aa), FASTA
scores: opt: 927, E(): 0,(33.5% identity in 659 aa
overlap); etc. Also similar to several other UvrD-like
proteins in Mycobacterium tuberculosis e.g. Rv3201c,
Rv3198c, Rv3202c. Contains PS00017 ATP/GTP-binding site
motif A (P-loop). Belongs to the UVRD subfamily of
helicases. Note that previously known as uvrD."
/db_xref="EnsemblGenomes-Gn:Rv0949"
/db_xref="EnsemblGenomes-Tr:CCP43697"
/db_xref="GOA:P9WMQ1"
/db_xref="InterPro:IPR000212"
/db_xref="InterPro:IPR005751"
/db_xref="InterPro:IPR013986"
/db_xref="InterPro:IPR014016"
/db_xref="InterPro:IPR014017"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR034739"
/db_xref="UniProtKB/Swiss-Prot:P9WMQ1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43697.1"
/translation="MSVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGA
GSGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKARYMWVST
FHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAI
SNLKNELIDPHQALAGLTEDSDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVL
QAFPQIAQYYRRRFRHVLVDEYQDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQ
SIYAFRGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREKRLW
TDAGAGELIVGYVADNEHDEARFVAEEIDALAEGSEITYNDVAVFYRTNNSSRSLEEV
LIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNPGDAVSLRRILNTPRRGIGDRAEA
CVAVYAENTGVGFGDALVAAAQGKVPMLNTRAEKAIAGFVEMFDELRGRLDDDLGELV
EAVLERTGYRRELEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGPDDEDVPDT
GVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRA
LDNPTELSEERRLAYVGITRARQRLYVSRAIVRSSWGQPMLNPESRFLREIPQELIDW
RRTAPKPSFSAPVSGAGRFGSARPSPTRSGASRRPLLVLQVGDRVTHDKYGLGRVEEV
SGVGESAMSLIDFGSSGRVKLMHNHAPVTKL"
gene complement(1060656..1061654)
/locus_tag="Rv0950c"
CDS complement(1060656..1061654)
/codon_start=1
/transl_table=11
/locus_tag="Rv0950c"
/product="Conserved hypothetical protein"
/note="Rv0950c, (MTCY10D7.24), len: 332 aa. Conserved
hypothetical protein, highly similar to
AL035500|MLCL373.02c|T45433 hypothetical protein from
Mycobacterium leprae (343 aa), FASTA scores: opt:
1500,E(): 0, (71.0% identity in 331 aa overlap).
C-terminus highly similar to part of various proteins e.g.
C-terminal part of NP_441943.1|NC_000911|NlpD lipoprotein
from Synechocystis sp (715 aa); N-terminal part of
NP_066789.1|NC_002576 putative peptidase from Rhodococcus
equi (546 aa); C-terminal part of NP_212396.1|NC_001318
conserved hypothetical protein from Borrelia burgdorferi
(417 aa); C-terminal part of P33648|NLPD_ECOLI|nlpd
lipoprotein from Escherichia coli (379 aa), FASTA scores:
opt: 276, E(): 2e-10, (29.9% identity in 234 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv0950c"
/db_xref="EnsemblGenomes-Tr:CCP43698"
/db_xref="GOA:P71560"
/db_xref="InterPro:IPR011055"
/db_xref="InterPro:IPR016047"
/db_xref="UniProtKB/TrEMBL:P71560"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43698.1"
/translation="MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELD
DLDLGDDCVFDYEAQLLAAPELDDLDDADDLAPEWLVAPTVVLTPEVTPVSRRVGQHR
KQPIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPR
GVQVIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRW
GVLHAGIDLANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLV
SVGERVMAGDQIATMGSRGFSTGPHLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG"
gene 1061964..1063127
/gene="sucC"
/locus_tag="Rv0951"
CDS 1061964..1063127
/codon_start=1
/transl_table=11
/gene="sucC"
/locus_tag="Rv0951"
/product="Probable succinyl-CoA synthetase (beta chain)
SucC (SCS-beta)"
/note="Rv0951, (MTCY10D7.23c), len: 387 aa. Probable
sucC,succinyl-CoA synthetase, beta chain, equivalent to
AL035500|MLCL373_3|NP_301241.1|NC_002677 succinyl-CoA
synthase [beta] chain from Mycobacterium leprae (393
aa),FASTA score: (86.7% identity in 391 aa overlap). Also
highly similar to others e.g. AB92671.1|AL356832
succinyl-CoA synthetase beta chain from Streptomyces
coelicolor (394 aa); P25126|SUCC_THEFL succinyl-CoA
synthetase beta chain from Thermus aquaticus (378 aa);
P07460|SUCC_ECOLI succinyl-CoA synthetase beta chain from
Escherichia coli (388 aa), FASTA scores: opt: 933, E():
0,(41.0% identity in 390 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0951"
/db_xref="EnsemblGenomes-Tr:CCP43699"
/db_xref="GOA:P9WGC5"
/db_xref="InterPro:IPR005809"
/db_xref="InterPro:IPR005811"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR013650"
/db_xref="InterPro:IPR013815"
/db_xref="InterPro:IPR016102"
/db_xref="InterPro:IPR017866"
/db_xref="UniProtKB/Swiss-Prot:P9WGC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43699.1"
/translation="MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMV
KAQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYL
SFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGH
LPAEVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQ
PGHAEFEDRAATDPLELKAKEHDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHG
GVKPANFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGITSCDAVATGIVKALG
MLGDEANKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA"
gene 1063140..1064051
/gene="sucD"
/locus_tag="Rv0952"
CDS 1063140..1064051
/codon_start=1
/transl_table=11
/gene="sucD"
/locus_tag="Rv0952"
/product="Probable succinyl-CoA synthetase (alpha chain)
SucD (SCS-alpha)"
/note="Rv0952, (MTCY10D7.22c), len: 303 aa. Probable
sucD,succinyl-CoA synthetase, alpha chain, equivalent to
AL035500|MLCL373_4|NP_301242.1|NC_002677 succinyl-CoA
synthase [alpha] chain from Mycobacterium leprae (300
aa),FASTA score: (86.3% identity in 300 aa overlap). Also
highly similar to others e.g. CAB92672.1|AL356832 from
Streptomyces coelicolor (294 aa); P53591|SUCD_COXBU from
Escherichia coli (288 aa), FASTA scores: opt: 855, E():
0,(53.8% identity in 286 aa overlap); etc. Contains
PS00399 ATP-citrate lyase and succinyl-CoA ligases active
site, and PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0952"
/db_xref="EnsemblGenomes-Tr:CCP43700"
/db_xref="GOA:P9WGC7"
/db_xref="InterPro:IPR003781"
/db_xref="InterPro:IPR005810"
/db_xref="InterPro:IPR005811"
/db_xref="InterPro:IPR016102"
/db_xref="InterPro:IPR017440"
/db_xref="InterPro:IPR033847"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGC7"
/inference="protein motif:PROSITE:PS00399"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43700.1"
/translation="MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNA
RKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEI
PLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPG
PIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVM
IGEIGGDAEERAADFIKTNVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQE
ALEAAGVKVGKTPSATAALAREILLSL"
gene complement(1064114..1064962)
/locus_tag="Rv0953c"
CDS complement(1064114..1064962)
/codon_start=1
/transl_table=11
/locus_tag="Rv0953c"
/product="Possible oxidoreductase"
/note="Rv0953c, (MTCY10D7.21), len: 282 aa. Possible
oxidoreductase, equivalent to CAA48222.1|X68102
hypothetical protein from Mycobacterium avium subsp.
paratuberculosis (166 aa). Similar to several hypothetical
proteins and oxidoreductases e.g.
AAK38097.1|AF323606_3|AF323606 putative F420-dependent
dehydrogenase from Rhodococcus erythropolis (295 aa);
NP_070025.1|NC_000917
N5,N10-methylenetetrahydromethanopterin reductase (mer-2)
from Archaeoglobus fulgidus (348 aa); etc. Also similar to
several hypothetical proteins and oxidoreductases from
Mycobacterium tuberculosis e.g.
Rv2161c|O06216|Z95388|MTCY270.07 (288 aa), FASTA scores:
opt: 633, E(): 0, (40.4% identity in 277 aa
overlap),Rv3079c (275 aa), Rv0791c (347 aa), etc. Contains
PS00201 Flavodoxin signature."
/db_xref="EnsemblGenomes-Gn:Rv0953c"
/db_xref="EnsemblGenomes-Tr:CCP43701"
/db_xref="GOA:P9WKN5"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019921"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/Swiss-Prot:P9WKN5"
/inference="protein motif:PROSITE:PS00201"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43701.1"
/translation="MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKRQ
AAHPTTGDASLPDDRYMRTLDPWVSLGAASAVTSRIRLATAVALPVEHDPITLAKSIA
TLDHLSHGRVSVGVGFGWNTDELVDHGVPPGRRRTMLREYLEAMRALWTQEEACYDGE
FVKFGPSWAWPKPVQPHIPVLVGAAGTEKNFKWIARSADGWITTPRDVDIDEPVKLLQ
DIWAAAGRDGLPQIVALDVKPVPDKLARWAELGVTEVLFGMPDRSADDAAAYVERLAA
KLACCV"
gene 1065127..1066038
/locus_tag="Rv0954"
CDS 1065127..1066038
/codon_start=1
/transl_table=11
/locus_tag="Rv0954"
/product="Probable conserved transmembrane protein"
/note="Rv0954, (MTCY10D7.20c), len: 303 aa. Probable
conserved transmembrane protein, highly similar to
34KD_MYCPA|Q04959 34 kDa antigenic protein from
Mycobacterium paratuberculosis (298 aa), FASTA scores:
opt: 1023, E(): 7.2e-36, (59.3% identity in 305 aa
overlap); AAC69251.1|U82111 34 kDa antigen precursor from
Mycobacterium leprae (336 aa); and AL035500|MLCL373.06
hypothetical membrane protein from Mycobacterium leprae
(297 aa), FASTA score: (55.6% identity in 315 aa overlap).
A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0954"
/db_xref="EnsemblGenomes-Tr:CCP43702"
/db_xref="GOA:P9WIR9"
/db_xref="InterPro:IPR035166"
/db_xref="UniProtKB/Swiss-Prot:P9WIR9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43702.1"
/translation="MTYSPGNPGYPQAQPAGSYGGVTPSFAHADEGASKLPMYLNIAV
AVLGLAAYFASFGPMFTLSTELGGGDGAVSGDTGLPVGVALLAALLAGVALVPKAKSH
VTVVAVLGVLGVFLMVSATFNKPSAYSTGWALWVVLAFIVFQAVAAVLALLVETGAIT
APAPRPKFDPYGQYGRYGQYGQYGVQPGGYYGQQGAQQAAGLQSPGPQQSPQPPGYGS
QYGGYSSSPSQSGSGYTAQPPAQPPAQSGSQQSHQGPSTPPTGFPSFSPPPPVSAGTG
SQAGSAPVNYSNPSGGEQSSSPGGAPV"
gene 1066078..1067445
/locus_tag="Rv0955"
CDS 1066078..1067445
/codon_start=1
/transl_table=11
/locus_tag="Rv0955"
/product="Probable conserved integral membrane protein"
/note="Rv0955, (MTCY10D7.19c), len: 455 aa. Probable
conserved integral membrane protein, highly similar to
AL035500|MLCL373_6 putative membrane protein from
Mycobacterium leprae (430 aa), FASTA score: (75.9%
identity in 419 aa overlap); and
AAL05878.1|AF411607_2|AF411607 unknown protein from
Mycobacterium avium subsp. paratuberculosis (409 aa). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv0955"
/db_xref="EnsemblGenomes-Tr:CCP43703"
/db_xref="GOA:P9WKN3"
/db_xref="UniProtKB/Swiss-Prot:P9WKN3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43703.1"
/translation="MNRVSASADDRAAGARPARDLVRVAFGPGVVALGIIAAVTLLQL
LIANSDMTGAWGAIASMWLGVHLVPISIGGRALGVMPLLPVLLMVWATARSTARATSP
QSSGLVVRWVVASALGGPLLMAAIALAVIHDASSVVTELQTPSALRAFTSVLVVHSVG
AATGVWSRVGRRALAATALPDWLHDSMRAAAAGVLALLGLSGVVTAGSLVVHWATMQE
LYGITDSIFGQFSLTVLSVLYAPNVIVGTSAIAVGSSAHIGFATFSSFAVLGGDIPAL
PILAAAPTPPLGPAWVALLIVGASSGVAVGQQCARRALPFVAAMAKLLVAAVAGALVM
AVLGYGGGGRLGNFGDVGVDEGALVLGVLFWFTFVGWVTVVIAGGISRRPKRLRPAPP
VELDADESSPPVDMFDGAASEQPPASVAEDVPPSHDDIANGLKAPTADDEALPLSDEP
PPRAD"
gene 1067561..1068208
/gene="purN"
/locus_tag="Rv0956"
CDS 1067561..1068208
/codon_start=1
/transl_table=11
/gene="purN"
/locus_tag="Rv0956"
/product="Probable 5'-phosphoribosylglycinamide
formyltransferase PurN (GART) (gar transformylase)
(5'-phosphoribosylglycinamide transformylase)"
/note="Rv0956, (MTCY10D7.18c), len: 215 aa. Probable
purN,5'-phosphoribosylglycinamide formyltransferase,
equivalent to AAF05726.1|AF191543_1|AF191543|PurN
phosphoribosylglycinamide formyltransferase from
Mycobacterium avium subsp. paratuberculosis (209 aa); and
AL035500|MLCL373_7 from Mycobacterium leprae (215
aa),FASTA score: (79.4% identity in 214 aa overlap). Also
highly similar to others e.g. BAA89443.1|AB003159 from
Corynebacterium ammoniagenes (199 aa);
NP_241498.1|NC_002570 from Bacillus halodurans (188 aa);
P08179|PUR3_ECOLI|B2500 from Escherichia coli strain K12
(212 aa), FASTA scores: opt: 380, E(): 2.4e-18, (36.6%
identity in 183 aa overlap); C-terminus of
P16340|PUR2_DROPS trifunctional purine biosynthetic
protein adenosine-3 from Drosophila pseudoobscura (Fruit
fly) (1364 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv0956"
/db_xref="EnsemblGenomes-Tr:CCP43704"
/db_xref="GOA:P9WHM5"
/db_xref="InterPro:IPR002376"
/db_xref="InterPro:IPR004607"
/db_xref="InterPro:IPR036477"
/db_xref="PDB:3DA8"
/db_xref="PDB:3DCJ"
/db_xref="UniProtKB/Swiss-Prot:P9WHM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43704.1"
/translation="MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAV
GVDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRIL
GPQFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILA
QQPVPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG"
gene 1068205..1069776
/gene="purH"
/locus_tag="Rv0957"
CDS 1068205..1069776
/codon_start=1
/transl_table=11
/gene="purH"
/locus_tag="Rv0957"
/product="Probable bifunctional purine biosynthesis
protein PurH: phosphoribosylaminoimidazolecarboxamide
formyltransferase (AICAR transformylase)
(5'-phosphoribosyl-5-aminoimidazole-4-carboxamide
formyltransferase) + inosinemonophosphate cyclohydrolase
(imp cyclohydrolase) (inosinicase) (imp synthetase)
(ATIC)"
/note="Rv0957, (MTCY10D7.17c), len: 523 aa. Probable
purH,bifunctional purine biosynthesis protein including
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide
formyltransferase and inosine-monophosphate (imp)
cyclohydrolase, equivalent to AL035500|MLCL373_8 putative
phosphoribosylaminoimidazolecarboxamide formyltransferase
from Mycobacterium leprae (527 aa), FASTA score: (88.1%
identity in 520 aa overlap); and
AF05727.1|AF191543_2|AF191543|PurH from Mycobacterium
avium subsp. paratuberculosis (527 aa). Also highly
similar to others e.g. CAB92677.1|AL356832 bifunctional
purine biosynthesis protein from Streptomyces coelicolor
(523 aa); NP_388534.1|NC_000964
phosphoribosylaminoimidazole carboxy formyl
formyltransferase + inosine-monophosphate cyclohydrolase
from Bacillus subtilis (512 aa); P15639|PUR9_ECOLI
phosphoribosylaminoimidazolecarboxamide formyltransferase
from Escherichia coli (529 aa), FASTA scores: opt: 1147,
E(): 0, (44.8% identity in 533 aa overlap); etc. Belongs
to the PurH family."
/db_xref="EnsemblGenomes-Gn:Rv0957"
/db_xref="EnsemblGenomes-Tr:CCP43705"
/db_xref="GOA:P9WHM7"
/db_xref="InterPro:IPR002695"
/db_xref="InterPro:IPR011607"
/db_xref="InterPro:IPR016193"
/db_xref="InterPro:IPR024051"
/db_xref="InterPro:IPR036914"
/db_xref="PDB:3ZZM"
/db_xref="PDB:4A1O"
/db_xref="UniProtKB/Swiss-Prot:P9WHM7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43705.1"
/translation="MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTA
KTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEA
FELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGV
LAALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWR
RVAMLRYGENPHQQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQ
TCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTI
FTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHG
DNPANWTLATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDA
ARLAVERGGERVRGAVAASDAFFPFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAK
AGVTLYLTGARHFAH"
gene 1069883..1071262
/locus_tag="Rv0958"
CDS 1069883..1071262
/codon_start=1
/transl_table=11
/locus_tag="Rv0958"
/product="Possible magnesium chelatase"
/note="Rv0958, (MTCY10D7.16c), len: 459 aa. Possible
magnesium chelatase, similar to others (especially in
N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10
putative magnesium protoporphyrin chelatase from
Deinococcus radiodurans (487 aa), FASTA scores: opt:
1148,E(): 0, (42.4% identity in 450 aa overlap);
Q44498|CHLI_ANAVA magnesium-chelatase subunit CHLI from
Anabaena variabilis (338 aa); T31460 probable magnesium
chelatase chain I bchI from Heliobacillus mobilis (363
aa); etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv0958"
/db_xref="EnsemblGenomes-Tr:CCP43706"
/db_xref="GOA:P71552"
/db_xref="InterPro:IPR002078"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P71552"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43706.1"
/translation="MSPSNLPRTVGELRAAGHRERGVKQEIRENLLTALADGDNVWPG
ILGFDDTVIPQVERALIAGHDFVLLGERGQGKTRLLRALAGLLDEWTPVIAGAELGEH
PYTPITPESIRRAAQLGDDLPVAWKHRSERYTEKLATPDTSVADLVGDVDPIKVAEGR
SLGDPETIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNVMEERDIQVRGYTLRLPLD
VLVVASANPEDYTNRGRIITPIKDRFGAEIRTHYPLELEAEMGVIVQEAHLSAQVSDY
LMQVLARFARYLRESRSIDQRSGVSARFAIAAAETVAAAARHRGAVLGETDPVARVVD
LGTVIDVLRGKLEFESGEEGREQAVLEHLLRRATADTASRVLGGIDVGSLVTAVEGGS
AVTTGERVSAKDVLAAVPGLPVVDRIARKLGAESEGERAAALELALEALYLAKRVDKV
CGEGQTVYG"
gene 1071255..1073273
/locus_tag="Rv0959"
CDS 1071255..1073273
/codon_start=1
/transl_table=11
/locus_tag="Rv0959"
/product="Conserved hypothetical protein"
/note="Rv0959, (MTCY10D7.15c), len: 672 aa. Conserved
hypothetical protein, similar to AE002069|AE002069_12
hypothetical protein from Deinococcus radiodurans (403
aa),FASTA scores: opt: 395, E(): 1.3e-15, (26.8% identity
in 426 aa overlap). Contains a single copy at the
N-terminus of a short repeat found three times in the M.
tuberculosis ORF O33341|MTV003.05c|AL008883."
/db_xref="EnsemblGenomes-Gn:Rv0959"
/db_xref="EnsemblGenomes-Tr:CCP43707"
/db_xref="GOA:P9WKN1"
/db_xref="InterPro:IPR002035"
/db_xref="InterPro:IPR036465"
/db_xref="UniProtKB/Swiss-Prot:P9WKN1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43707.1"
/translation="MAKSDGDDPLRPASPRLRSSRRHSLRYSAYTGGPDPLAPPVDLR
DALEQIGQDVMAGASPRRALSELLRRGTRNLTGADRLAAEVNRRRRELLRRNNLDGTL
QEIKKLLDEAVLAERKELARALDDDARFAELQLDALPASPAKAVQELAEYRWRSGQAR
EKYEQIKDLLGRELLDQRFAGMKQALAGATDDDRRRVTEMLDDLNDLLDKHARGEDTQ
RDFDEFMTKHGEFFPENPRNVEELLDSLAKRAAAAQRFRNSLSQEQRDELDALAQQAF
GSPALMRALDRLDAHLQAARPGEDWTGSQQFSGDNPFGMGEGTQALADIAELEQLAEQ
LSQSYPGASMDDVDLDALARQLGDQAAVDARTLAELERALVNQGFLDRGSDGQWRLSP
KAMRRLGETALRDVAQQLSGRHGERDHRRAGAAGELTGATRPWQFGDTEPWHVARTLT
NAVLRQAAAVHDRIRITVEDVEVAETETRTQAAVALLVDTSFSMVMENRWLPMKRTAL
ALHHLVCTRFRSDALQIIAFGRYARTVTAAELTGLAGVYEQGTNLHHALALAGRHLRR
HAGAQPVVLVVTDGEPTAHLEDFDGDGTSVFFDYPPHPRTIAHTVRGFDDMARLGAQV
TIFRLGSDPGLARFIDQVARRVQGRVVVPDLDGLGAAVVGDYLRFRRR"
gene 1073327..1073548
/gene="vapB9"
/locus_tag="Rv0959A"
CDS 1073327..1073548
/codon_start=1
/transl_table=11
/gene="vapB9"
/locus_tag="Rv0959A"
/product="Possible antitoxin VapB9"
/note="Rv0959A, len: 73 aa. Possible vapB9, antitoxin,
part of toxin-antitoxin (TA) operon with Rv0960 (See Arcus
et al., 2005; Pandey and Gerdes, 2005). Weakly similar to
others in Mycobacterium tuberculosis e.g. Rv1721c"
/db_xref="EnsemblGenomes-Gn:Rv0959A"
/db_xref="EnsemblGenomes-Tr:CCP43708"
/db_xref="GOA:P9WJ55"
/db_xref="InterPro:IPR010985"
/db_xref="UniProtKB/Swiss-Prot:P9WJ55"
/protein_id="CCP43708.1"
/translation="MKTLYLRNVPDDVVERLERLAELAKTSVSAVAVRELTEASRRAD
NPALLGDLPDIGIDTTELIGGIDAERAGR"
gene 1073545..1073928
/gene="vapC9"
/locus_tag="Rv0960"
CDS 1073545..1073928
/codon_start=1
/transl_table=11
/gene="vapC9"
/locus_tag="Rv0960"
/product="Possible toxin VapC9"
/note="Rv0960, (MTCY10D7.14c), len: 127 aa. Possible
vapC9,toxin, part of toxin-antitoxin (TA) operon with
Rv0959A,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to others in
Mycobacterium tuberculosis e.g. Rv0065|MTV030.08 (133 aa),
FASTA scores: E(): 1.5e-14, (38.3% identity in 128 aa
overlap), Rv1720c (129 aa), and Rv0549c (137 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0960"
/db_xref="EnsemblGenomes-Tr:CCP43709"
/db_xref="GOA:P9WFA9"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43709.1"
/translation="MIVVDASAALAALLNDGQARQLIAAERLHVPHLVDSEIASGLRR
LAQRDRLGAADGRRALQTWRRLAVTRYPVVGLFERIWEIRANLSAYDASYVALAEALN
CALVTADLRLSDTGQAQCPITVVPR"
gene 1074074..1074421
/locus_tag="Rv0961"
CDS 1074074..1074421
/codon_start=1
/transl_table=11
/locus_tag="Rv0961"
/product="Probable integral membrane protein"
/note="Rv0961, (MTCY10D7.13c), len: 115 aa. Probable
integral membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv0961"
/db_xref="EnsemblGenomes-Tr:CCP43710"
/db_xref="GOA:P9WKM9"
/db_xref="UniProtKB/Swiss-Prot:P9WKM9"
/protein_id="CCP43710.1"
/translation="MRVPSQWMISSRVTVAWNIVGYLVYAALAFVGGFAVWFSLFFAM
ATDGCHDSACDASYHVFPAMVTMWIGVGAVLLLTLVVMVRNSSRGNVVIGWPFVGLLA
LGLVYVAADAVLH"
gene complement(1074440..1075114)
/gene="lprP"
/locus_tag="Rv0962c"
CDS complement(1074440..1075114)
/codon_start=1
/transl_table=11
/gene="lprP"
/locus_tag="Rv0962c"
/product="Possible lipoprotein LprP"
/note="Rv0962c, (MTCY10D7.12), len: 224 aa. Possible
lprP,lipoprotein. Contains possible N-terminal signal
sequence and appropriately positioned PS00013 Prokaryotic
membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0962c"
/db_xref="EnsemblGenomes-Tr:CCP43711"
/db_xref="GOA:P9WK39"
/db_xref="InterPro:IPR032018"
/db_xref="UniProtKB/Swiss-Prot:P9WK39"
/protein_id="CCP43711.1"
/translation="MKRTSRSLTAALLGIAALLAGCIKPNTFDPYANPGRGELDRRQK
IVNGRPDLETVQQQLANLDATIRAMIAKYSPQTRFSTGVTVSHLTNGCNDPFTRTIGR
QEASELFFGRPAPTPQQWLQIVTELAPVFKAAGFRPNNSVPGDPPQPLGAPNYSQIRD
DGVTINLVNGDNRGPLGYSYNTGCHPPAAWRTAPPPLNMRPANDPDVHYPYLYGSPGG
RTRDAY"
gene complement(1075297..1076097)
/locus_tag="Rv0963c"
CDS complement(1075297..1076097)
/codon_start=1
/transl_table=11
/locus_tag="Rv0963c"
/product="Conserved hypothetical protein"
/note="Rv0963c, (MTCCY10D7.11), len: 266 aa. Conserved
hypothetical protein, similar in part to other conserved
hypothetical proteins from Mycobacterium tuberculosis e.g.
Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: E():
1.2e-23,(39.0% identity in 254 aa overlap); Rv2542 (403
aa); Rv2079 (656 aa). Also similar in part to
AL133423|SC4A7_3 hypothetical secreted protein from
Streptomyces coelicolor (406 aa), FASTA scores: opt: 231,
E(): 6.8e-07, (31.4% identity in 204 aa overlap); and
SCH10.21c|T36533 hypothetical protein from Streptomyces
coelicolor (329 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0963c"
/db_xref="EnsemblGenomes-Tr:CCP43712"
/db_xref="InterPro:IPR010427"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WKM7"
/protein_id="CCP43712.1"
/translation="MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTS
LILLDTASDPRKVLAAVGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAA
ELRERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVS
DQHITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGV
NDHVANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA"
gene complement(1076196..1076678)
/locus_tag="Rv0964c"
CDS complement(1076196..1076678)
/codon_start=1
/transl_table=11
/locus_tag="Rv0964c"
/product="Hypothetical protein"
/note="Rv0964c, (MTCY10D7.10), len: 160 aa. Hypothetical
unknown protein. Equivalent to AAK45241.1 from
Mycobacterium tuberculosis strain CDC1551 (138 aa) but
longer 22 aa."
/db_xref="EnsemblGenomes-Gn:Rv0964c"
/db_xref="EnsemblGenomes-Tr:CCP43713"
/db_xref="UniProtKB/Swiss-Prot:P9WKM5"
/protein_id="CCP43713.1"
/translation="MGLLGFGGAAAEAAQVATHHTTVLLDHHAGACEAVARAAEKAAE
EVAAIKMRLQVIRDAAREHHLTIAYATGTALPPPDLSSYSPADQQAILNTAIRRASNV
CWPTPRPPMRIWPRRFDAPPGPCRASRSMPNSAMRHPQCRRCRRRTATLRRSSGGGIR
"
gene complement(1076778..1077197)
/locus_tag="Rv0965c"
CDS complement(1076778..1077197)
/codon_start=1
/transl_table=11
/locus_tag="Rv0965c"
/product="Conserved hypothetical protein"
/note="Rv0965c, (MTCY10D7.09), len: 139 aa. Conserved
hypothetical protein, showing weak similarity with
Rv2798c|MTCY16B7.45 conserved hypothetical protein from
Mycobacterium tuberculosis (108 aa), FASTA scores: E():
5.6e-12, (38.9% identity in 90 aa overlap). Equivalent to
AAK45242.1 from Mycobacterium tuberculosis strain CDC1551
(146 aa) but shorter 7 aa."
/db_xref="EnsemblGenomes-Gn:Rv0965c"
/db_xref="EnsemblGenomes-Tr:CCP43714"
/db_xref="UniProtKB/Swiss-Prot:P9WKM3"
/protein_id="CCP43714.1"
/translation="MRVNRPQCARVPYSAESLVRVEASWYGRTLRAIPEVLSQVGYQQ
ADHGESLLTSHHCCLGAAEGARPGWVGSSAGALSGLLDSWAEASTAHAARIGDHSYGM
HLAAVGFAEMEEHNAAALAAVYPTGGGSARCDGVDVS"
gene complement(1077233..1077835)
/locus_tag="Rv0966c"
CDS complement(1077233..1077835)
/codon_start=1
/transl_table=11
/locus_tag="Rv0966c"
/product="Conserved protein"
/note="Rv0966c, (MTCY10D7.08), len: 200 aa. Conserved
protein, equivalent to AL035500|MLCL373_12 conserved
hypothetical protein from Mycobacterium leprae (200
aa),FASTA scores: opt: 1080, E(): 0, (79.5% identity in
200 aa overlap). Also highly similar to
SCE6.30c|CAB88834.1|AL353832 hypothetical protein from
Streptomyces coelicolor (277 aa). Some similarity to
Rv2862c|MTV007.08 conserved hypothetical protein from
Mycobacterium tuberculosis (194 aa), FASTA scores: E():
3.1e-06, (31.5% identity in 184 aa overlap). Equivalent to
AAK45243.1 from Mycobacterium tuberculosis strain CDC1551
(230 aa) but shorter 30 aa. Note that Rv0966c has been
shortened since first entry."
/db_xref="EnsemblGenomes-Gn:Rv0966c"
/db_xref="EnsemblGenomes-Tr:CCP43715"
/db_xref="GOA:P9WKM1"
/db_xref="InterPro:IPR012551"
/db_xref="UniProtKB/Swiss-Prot:P9WKM1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43715.1"
/translation="MSNSAQRDARNSRDESARASDTDRIQIAQLLAYAAEQGRLQLTD
YEDRLARAYAATTYQELDRLRADLPGAAIGPRRGGECNPAPSTLLLALLGGFERRGRW
NVPKKLTTFTLWGSGVLDLRYADFTSTEVDIRAYSIMGAQTILLPPEVNVEIHGHRVM
GGFDRKVVGEGTRGVPTVRIRGFSLWGDVGIKRKPRKPRK"
gene 1077975..1078334
/gene="csoR"
/locus_tag="Rv0967"
CDS 1077975..1078334
/codon_start=1
/transl_table=11
/gene="csoR"
/locus_tag="Rv0967"
/product="Copper-sensitive operon repressor CsoR"
/note="Rv0967, (MTCY10D7.07c), len: 119 aa.
CsoR,copper-sensitive operon repressor, part of cso operon
(See Liu et al., 2007), similar to hypothetical proteins
from several organisms e.g. AE002074|AE002074_11 from
Deinococcus radiodurans (102 aa), FASTA scores: opt:
233,E(): 8.6e-10, (47.0% identity in 83 aa overlap);
O32222|Z99121|YVGZ from Bacillus subtilis (101 aa), FASTA
scores: opt:228, E(): 3.2e-15, (38.0% identity in 92 aa
overlap); etc. Also similar to Mycobacterium tuberculosis
hypothetical proteins Rv0190, and Rv1766."
/db_xref="EnsemblGenomes-Gn:Rv0967"
/db_xref="EnsemblGenomes-Tr:CCP43716"
/db_xref="GOA:P9WP49"
/db_xref="InterPro:IPR003735"
/db_xref="InterPro:IPR038390"
/db_xref="PDB:2HH7"
/db_xref="UniProtKB/Swiss-Prot:P9WP49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43716.1"
/translation="MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQIS
AVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGA
AVGESATEEPMPDASNM"
gene 1078391..1078687
/locus_tag="Rv0968"
CDS 1078391..1078687
/codon_start=1
/transl_table=11
/locus_tag="Rv0968"
/product="Conserved protein"
/note="Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved
protein, part of cso operon, similar to
NP_301579.1|NC_002677 conserved hypothetical protein from
Mycobacterium leprae (92 aa). Also highly similar to
conserved hypothetical proteins from Mycobacterium
tuberculosis e.g. Rv3269 (93 aa), FASTA score: (51.1%
identity in 94 aa overlap); and Rv1993c (90 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0968"
/db_xref="EnsemblGenomes-Tr:CCP43717"
/db_xref="GOA:P9WKL9"
/db_xref="InterPro:IPR009963"
/db_xref="UniProtKB/Swiss-Prot:P9WKL9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43717.1"
/translation="MVWHGFLAKAVPTVVTGAVGVAAYEALRKMVVKAPLRAATVSVA
AWGIRLAREAERKAGESAEQARLMFADVLAEASERAGEEVPPLAVAGSDDGHDH"
gene 1078743..1081055
/gene="ctpV"
/locus_tag="Rv0969"
CDS 1078743..1081055
/codon_start=1
/transl_table=11
/gene="ctpV"
/locus_tag="Rv0969"
/product="Probable metal cation transporter P-type ATPase
CtpV"
/note="Rv0969, (MTCY10D7.05c), len: 770 aa. Probable
ctpV,metal cation transporter P-type ATPase (transmembrane
protein) (see citation below), part of cso operon, highly
similar (except in N-terminus) to others e.g.
NP_391230.1|NC_000964 similar to heavy metal-transporting
ATPase from Bacillus subtilis (803 aa);
P37279|ATCS_SYNP7|PACS cation-transporting ATPase from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(747 aa), FASTA scores: opt: 1851, E(): 0, (52.1% identity
in 664 aa overlap); etc. Equivalent to AAK45246.1 from
Mycobacterium tuberculosis strain CDC1551 (792 aa) but
shorter 22 aa. Contains PS00154 E1-E2 ATPases
phosphorylation site. Belongs to the cation transport
ATPases family (E1-E2 ATPases)."
/db_xref="EnsemblGenomes-Gn:Rv0969"
/db_xref="EnsemblGenomes-Tr:CCP43718"
/db_xref="GOA:P9WPS3"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR027256"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPS3"
/inference="protein motif:PROSITE:PS00154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43718.1"
/translation="MRVCVTGFNVDAVRAVAIEETVSQVTGVHAVHAYPRTASVVIWY
SPELGDTAAVLSAITKAQHVPAELVPARAPHSAGVRGVGVVRKITGGIRRMLSRPPGV
DKPLKASRCGGRPRGPVRGSASWPGEQNRRERRTWLPRVWLALPLGLLALGSSMFFGA
YPWAGWLAFAATLPVQFVAGWPILRGAVQQARALTSNMDTLIALGTLTAFVYSTYQLF
AGGPLFFDTSALIIAFVVLGRHLEARATGKASEAISKLLELGAKEATLLVDGQELLVP
VDQVQVGDLVRVRPGEKIPVDGEVTDGRAAVDESMLTGESVPVEKTAGDRVAGATVNL
DGLLTVRATAVGADTALAQIVRLVEQAQGDKAPVQRLADRVSAVFVPAVIGVAVATFA
GWTLIAANPVAGMTAAVAVLIIACPCALGLATPTAIMVGTGRGAELGILVKGGEVLEA
SKKIDTVVFDKTGTLTRARMRVTDVIAGQRRQPDQVLRLAAAVESGSEHPIGAAIVAA
AHERGLAIPAANAFTAVAGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQE
ERGRTAVFVGQDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIA
KQVGIEKVLAEVLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADLGIAIGTGTD
VAIEASDITLMSGRLDGVVRAIELSRQTLRTIYQNLGWAFGYNTAAIPLAALGALNPV
VAGAAMGFSSVSVVTNSLRLRRFGRDGRTA"
gene 1081052..1081684
/locus_tag="Rv0970"
CDS 1081052..1081684
/codon_start=1
/transl_table=11
/locus_tag="Rv0970"
/product="Probable conserved integral membrane protein"
/note="Rv0970, (MTCY10D7.04c), len: 210 aa. Probable
conserved integral membrane protein, part of cso
operon,equivalent to NP_302348.1|NC_002677 probable
integral membrane protein from Mycobacterium leprae (210
aa)."
/db_xref="EnsemblGenomes-Gn:Rv0970"
/db_xref="EnsemblGenomes-Tr:CCP43719"
/db_xref="GOA:P9WKL7"
/db_xref="InterPro:IPR033458"
/db_xref="UniProtKB/Swiss-Prot:P9WKL7"
/protein_id="CCP43719.1"
/translation="MIHDLMLRWVVTGLFVLTAAECGLAIIAKRRPWTLIVNHGLHFA
MAVAMAVMAWPWGARVPTTGPAVFFLLAAVWFGATAVVAVRGTATRGLYGYHGLMMLA
TAWMYAAMNPRLLPVRSCTEYATEPDGSMPAMDMTAMNMPPNSGSPIWFSAVNWIGTV
GFAVAAVFWACRFVMERRQEATQSRLPGSIGQAMMAAGMAMLFFAMLFPV"
gene complement(1081775..1082584)
/gene="echA7"
/locus_tag="Rv0971c"
CDS complement(1081775..1082584)
/codon_start=1
/transl_table=11
/gene="echA7"
/locus_tag="Rv0971c"
/product="Probable enoyl-CoA hydratase EchA7 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv0971c, (MTCY10D7.03), len: 269 aa. Probable
echA7,enoyl-CoA hydratase, similar to many e.g.
CAB95895.1|AL359988 putative enoyl CoA hydratase from
Streptomyces coelicolor (247 aa); P24162|ECHH_RHOCA
enoyl-CoA hydratase from Rhodobacter capsulatus (257
aa),FASTA scores: opt: 369, E(): 2.6e-15, (33.7% identity
in 246 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0971c"
/db_xref="EnsemblGenomes-Tr:CCP43720"
/db_xref="GOA:P71540"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:P71540"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43720.1"
/translation="MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLS
AAEADPAVRLVVLGHTGGTFCAGADLSEAGGGGGDPYRMAVARAREMTALLRAIVESP
LPVVGAINGHVRAGGFGLVGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPR
AAARYYLTGEKFGAREAADIGLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTA
AVLEGFDRDAERLTEESARLFVSDEAREGMLAFLQKRPPRWVQPATMRAAD"
gene complement(1082584..1083750)
/gene="fadE12"
/locus_tag="Rv0972c"
CDS complement(1082584..1083750)
/codon_start=1
/transl_table=11
/gene="fadE12"
/locus_tag="Rv0972c"
/product="Acyl-CoA dehydrogenase FadE12"
/note="Rv0972c, (MTCY10D7.02), len: 388 aa.
fadE12,acyl-CoA dehydrogenase, highly similar to many e.g.
CAB95893.1|AL359988 putative acyl CoA dehydrogenase from
Streptomyces coelicolor (382 aa); P45857|ACDB_BACSU from
Bacillus subtilis (379 aa), FASTA scores: opt: 576, E():
2.3e-26, (29.7% identity in 381 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0972c"
/db_xref="EnsemblGenomes-Tr:CCP43721"
/db_xref="GOA:P9WQG3"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/Swiss-Prot:P9WQG3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43721.1"
/translation="MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSEL
WAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSPAINGTIIAK
FGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFIS
GIDQAQAVLVVGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSPERQFQVFLDD
VRLPADALVGAEDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTP
IGAHQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRA
VDQAVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY"
gene complement(1083747..1085750)
/gene="accA2"
/gene_synonym="bccA"
/locus_tag="Rv0973c"
CDS complement(1083747..1085750)
/codon_start=1
/transl_table=11
/gene="accA2"
/gene_synonym="bccA"
/locus_tag="Rv0973c"
/product="Probable acetyl-/propionyl-coenzyme A
carboxylase alpha chain (alpha subunit) AccA2: biotin
carboxylase + biotin carboxyl carrier protein (BCCP)"
/note="Rv0973c, (MTV044.01c, MTCY10D7.01), len: 667 aa.
Probable accA2 (alternate gene name:
bccA),acetyl-/propionyl-coenzyme A carboxylase (alpha
subunit) [includes: biotin carboxylase ; biotin carboxyl
carrier protein (BCCP)], highly similar to others e.g.
CAB95892.1|AL359988 putative acetyl/propionyl CoA
carboxylase alpha subunit from Streptomyces coelicolor
(614 aa); NP_250702.1|NC_002516 probable acyl-CoA
carboxylase alpha chain from Pseudomonas aeruginosa (655
aa); NP_420971.1|NC_002696 acetyl/propionyl-CoA
carboxylase alpha subunit from Caulobacter crescentus (
654 aa); NP_251581.1|NC_002516 probable biotin
carboxylase/biotin carboxyl carrier protein from
Pseudomonas aeruginosa (661 aa); etc. Also highly similar
to others from Mycobacterium tuberculosis e.g.
Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 probable
acetyl-/propionyl-coenzyme A carboxylase alpha chain
(alpha subunit) (654 aa), FASTA scores, opt: 250, E():
4e-09,(28.6% identity in 182 aa overlap); and
Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127
aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in
500 aa overlap). Contains PS00867 Carbamoyl-phosphate
synthase subdomain signature 2 and PS00188
Biotin-requiring enzymes attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0973c"
/db_xref="EnsemblGenomes-Tr:CCP43722"
/db_xref="GOA:P71538"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR001882"
/db_xref="InterPro:IPR005479"
/db_xref="InterPro:IPR005481"
/db_xref="InterPro:IPR005482"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR011764"
/db_xref="InterPro:IPR016185"
/db_xref="UniProtKB/TrEMBL:P71538"
/inference="protein motif:PROSITE:PS00188"
/inference="protein motif:PROSITE:PS00867"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43722.1"
/translation="MGITRVLVANRGEIARRVFATCRRLGLGTVAVYTDPDAAAPHVA
EADARVRLPQTTDYLNAEAIIAAAQAAGADAVHPGYGFLSENAEFAAAVQEAGLTWVG
PPVDAVRAMGSKIESKKLMAAAGVPVLEELDPDAVTTAQLPVLVKASAGGGGRGMRVV
HELSALPAEVEAARREAQSAFGDPTVFCERYLPTGHHVEVQVMADTHGTVWAVGEREC
SIQRRHQKIIEEAPSPLVERVPGMRAKLFDAARLAASAIGYTGAGTVEFLADDSPGRE
GEFYFLEMNTRLQVEHPVTEETTGLDLVELQLMIADCGRLDTEPPPAQGYSIEARLYA
EDPAHGWQPQAGVMHTIEVPGVRAQFDSLGQRTGIRLDSGIVDGSTVSIHYDPMLAKV
VSYGATRRQAALVLADALVRARLHGLRTNRELLVNVLRHPAFLDGATDTGFFDTHGMA
ELSTPLADTATLRLSAIAAALADAEHNRASAGVFSSIPSGWRNLASGYQVKTYRDDAD
TEHRVEYRFTRTGLALPGDPVVQLVSADVDQVVLAQDGVAHGFTVARHGPDVYVDSAR
GPVHLVALSRFPEPSSAVEQGSLVAPMPGNVIRIGAEVGDTVTAGQPLIWLEAMKMEH
TIAAPADGVLTHVSVNTGQQVEVGAILARVEAPQNGPAEGDSP"
gene complement(1085756..1087345)
/gene="accD2"
/locus_tag="Rv0974c"
CDS complement(1085756..1087345)
/codon_start=1
/transl_table=11
/gene="accD2"
/locus_tag="Rv0974c"
/product="Probable acetyl-/propionyl-CoA carboxylase (beta
subunit) AccD2"
/note="Rv0974c, (MTV044.02c), len: 529 aa. Probable
accD2,acetyl-/propionyl-CoA carboxylase (beta subunit),
highly similar to many e.g. CAB95891.1|AL35998 putative
acetyl/propionyl CoA carboxylase beta subunit from
Streptomyces coelicolor (532 aa); NP_250704.1|NC_002516
probable acyl-CoA carboxyltransferase beta chain from
Pseudomonas aeruginosa (535 aa); BAB16296.1|AB039884
acetyl-CoA carboxylase carboxyltransferase from Myxococcus
xanthus (538 aa); NP_420973.1|NC_002696 putative
propionyl-CoA carboxylase beta subunit from Caulobacter
crescentus (530 aa); etc. Also similar to other from
Mycobacterium tuberculosis: Rv2502c|ACCD1,
Rv3799c|ACCD4,etc. Could belong to the ACCD/PCCB family."
/db_xref="EnsemblGenomes-Gn:Rv0974c"
/db_xref="EnsemblGenomes-Tr:CCP43723"
/db_xref="GOA:O86318"
/db_xref="InterPro:IPR011762"
/db_xref="InterPro:IPR011763"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR034733"
/db_xref="UniProtKB/TrEMBL:O86318"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43723.1"
/translation="MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVD
RHHARGNLTPRERIELLVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIV
ANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGE
ESDDESLGGAEMHARISGLADYFALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLF
DAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGIL
ANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMIN
AVSNSTVPHISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIV
ARAAAEARGQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTRTVLGM
CLSAIANGPIKGTSNFGVFRM"
gene complement(1087348..1088496)
/gene="fadE13"
/locus_tag="Rv0975c"
CDS complement(1087348..1088496)
/codon_start=1
/transl_table=11
/gene="fadE13"
/locus_tag="Rv0975c"
/product="Probable acyl-CoA dehydrogenase FadE13"
/note="Rv0975c, (MTV044.03c), len: 382 aa. Probable
fadE13,acyl-CoA dehydrogenase, highly similar to many e.g.
T35427 probable acyl-CoA dehydrogenase from Streptomyces
coelicolor (382 aa); M74096|HUMACADL_1 Human long chain
acyl-CoA dehydrogenase from Homo sapiens (430 aa), FASTA
scores: opt: 819, E(): 0, (37.0% identity in 376 aa
overlap); etc. Also similar to others from Mycobacterium
tuberculosis e.g. fadE20|Z98209|MTCY154_4 (386 aa), FASTA
scores: (40.3% identity in 375 aa overlap). Contains
PS00073 Acyl-CoA dehydrogenases signature 2. Belongs to
the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv0975c"
/db_xref="EnsemblGenomes-Tr:CCP43724"
/db_xref="GOA:O86319"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:O86319"
/inference="protein motif:PROSITE:PS00073"
/protein_id="CCP43724.1"
/translation="MNIWTTPERQQLRKTVRAFAEREILPHVDEWERIGELPRGLHRL
AGAAGLLGAGFPEAVGGGGGDGADPVIICEEMHQAGAPGGVYASLFTCGIAVPHMVAS
GDERLIATYVRPTLAGEKIGALAITEPGGGSDVGHLRTSAVRDGDHYVINGAKTYITS
GVRADYVVTAVRTGGPGAAGVSLLVVEKDTPGFEVTRKLDKMGWRSSDTAELCYTDVA
VPATNLVGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLI
SRQSVQNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQ
AVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALAAKTLGYQS"
gene complement(1088493..1090175)
/locus_tag="Rv0976c"
CDS complement(1088493..1090175)
/codon_start=1
/transl_table=11
/locus_tag="Rv0976c"
/product="Conserved hypothetical protein"
/note="Rv0976c, (MTV044.04c), len: 560 aa. Conserved
hypothetical protein, highly similar to others e.g.
CAB95890.1|AL359988 conserved hypothetical protein from
Streptomyces coelicolor (558 aa); P_251576.1|NC_002516
hypothetical protein from Pseudomonas aeruginosa (600 aa);
etc. N-terminal part highly similar to AL035500|MLCL373_14
probable pseudogene from Mycobacterium leprae (163
aa),FASTA score: (50.0% identity in 122 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv0976c"
/db_xref="EnsemblGenomes-Tr:CCP43725"
/db_xref="InterPro:IPR010839"
/db_xref="UniProtKB/TrEMBL:O86320"
/protein_id="CCP43725.1"
/translation="MRIGNCSGFYGDRLSAMREMLTGGELDYLTGDYLAELTMLILGR
DRMKNPDRGYAKTFLAQLEDCLGLAHDRGVRIVTNAGGLNPAGLANAVRALAARLGIP
AQVAHVEGDDLQPRAAELGLGTPLTANAYLGAWGIVDCFERGADVVVTGRVTDASVVV
GAAAAHFGWGRTDYHRLAGAVVAGHVIECGVQATGGNYAFFTEIGDLTHAGFPLAEIA
ADGSSVITKHHGTGGLVSVDTITAQLLYEITGARYANPDVTARMDSVELSPDGPDRVR
ISGVIGEPPPPTYKVSLNSIGGFRNAMTFVLTGLDIDAKADLVRRQLEAALTVKPAEL
QWTLARTDHPDADTEETASALLTCVARDPDPANVGRQFSSAAVELALASYPGFTATAP
PGDGQVYGVFTPGYVDAGKVAHIAVHADGTRTEIPCATETLELAPAHPPALPDPLPAG
PTRRVPLGLIAGARSGDKGGSANVGVWVRTDEQWRWLAHTLTVELLKELLPETAGLVV
TRHVLPNLRALNFVIEAILGQGVAYQARFDPQAKGLGEWLRSRHVEIPETLL"
gene 1090373..1093144
/gene="PE_PGRS16"
/locus_tag="Rv0977"
CDS 1090373..1093144
/codon_start=1
/transl_table=11
/gene="PE_PGRS16"
/locus_tag="Rv0977"
/product="PE-PGRS family protein PE_PGRS16"
/note="Rv0977, (MTV044.05), len: 923 aa. PE_PGRS16, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
highly similar to other PGRS-type sequences e.g.
AL0091|MTV004_1 from Mycobacterium tuberculosis (1125 aa),
FASTA score: (45.4% identity in 959 aa overlap);
Z80225|MTCY441_4 from Mycobacterium tuberculosis (778 aa),
FASTA score: (51.5% identity in 750 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0977"
/db_xref="EnsemblGenomes-Tr:CCP43726"
/db_xref="GOA:Q79FU3"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR021109"
/db_xref="PDB:4EHC"
/db_xref="UniProtKB/Swiss-Prot:Q79FU3"
/protein_id="CCP43726.1"
/translation="MSFVVTAPPVLASAASDLGGIASMISEANAMAAVRTTALAPAAA
DEVSAAIAALFSSYARDYQTLSVQVTAFHVQFAQTLTNAGQLYAVVDVGNGVLLKTEQ
QVLGVINAPTQTLVGRPLIGDGTHGAPGTGQNGGAGGILWGNGGNGGSGAPGQPGGRG
GDAGLFGHGGHGGVGGPGIAGAAGTAGLPGGNGANGGSGGIGGAGGAGGNGGLLFGNG
GAGGQGGSGGLGGSGGTGGAGMAAGPAGGTGGIGGIGGIGGAGGVGGHGSALFGHGGI
NGDGGTGGMGGQGGAGGNGWAAEGITVGIGEQGGQGGDGGAGGAGGIGGSAGGIGGSQ
GAGGHGGDGGQGGAGGSGGVGGGGAGAGGDGGAGGIGGTGGNGSIGGAAGNGGNGGRG
GAGGMATAGSDGGNGGGGGNGGVGVGSAGGAGGTGGDGGAAGAGGAPGHGYFQQPAPQ
GLPIGTGGTGGEGGAGGAGGDGGQGDIGFDGGRGGDGGPGGGGGAGGDGSGTFNAQAN
NGGDGGAGGVGGAGGTGGTGGVGADGGRGGDSGRGGDGGNAGHGGAAQFSGRGAYGGE
GGSGGAGGNAGGAGTGGTAGSGGAGGFGGNGADGGNGGNGGNGGFGGINGTFGTNGAG
GTGGLGTLLGGHNGNIGLNGATGGIGSTTLTNATVPLQLVNTTEPVVFISLNGGQMVP
VLLDTGSTGLVMDSQFLTQNFGPVIGTGTAGYAGGLTYNYNTYSTTVDFGNGLLTLPT
SVNVVTSSSPGTLGNFLSRSGAVGVLGIGPNNGFPGTSSIVTAMPGLLNNGVLIDESA
GILQFGPNTLTGGITISGAPISTVAVQIDNGPLQQAPVMFDSGGINGTIPSALASLPS
GGFVPAGTTISVYTSDGQTLLYSYTTTATNTPFVTSGGVMNTGHVPFAQQPIYVSYSP
TAIGTTTFN"
gene complement(1093361..1094356)
/gene="PE_PGRS17"
/locus_tag="Rv0978c"
CDS complement(1093361..1094356)
/codon_start=1
/transl_table=11
/gene="PE_PGRS17"
/locus_tag="Rv0978c"
/product="PE-PGRS family protein PE_PGRS17"
/note="Rv0978c, (MTV044.06c), len: 331 aa.
PE_PGRS17,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to others e.g. Z95387|MTCY1A10_19
from Mycobacterium tuberculosis (461 aa), FASTA score:
(73.6% identity in 277 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0978c"
/db_xref="EnsemblGenomes-Tr:CCP43727"
/db_xref="GOA:Q79FU2"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR001258"
/db_xref="InterPro:IPR011964"
/db_xref="InterPro:IPR013017"
/db_xref="InterPro:IPR015943"
/db_xref="UniProtKB/Swiss-Prot:Q79FU2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43727.1"
/translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQD
EVSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLD
AINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAG
LIGNGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFN
DPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFV
TNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS"
gene complement(1094670..1094864)
/locus_tag="Rv0979c"
CDS complement(1094670..1094864)
/codon_start=1
/transl_table=11
/locus_tag="Rv0979c"
/product="Hypothetical protein"
/note="Rv0979c, (MTV044.07c), len: 64 aa (unlikely ORF).
Hypothetical unknown protein. Start codon changed since
first submission (-44 aa)."
/db_xref="EnsemblGenomes-Gn:Rv0979c"
/db_xref="EnsemblGenomes-Tr:CCP43728"
/db_xref="UniProtKB/TrEMBL:O53892"
/protein_id="CCP43728.1"
/translation="MGFRTQVGAATIASTMTWRIPVEDGPAQFRAGVGPGRDRQFTVV
APMVVGLWDRNRRPGWQWPS"
gene 1094886..1095059
/gene="rpmF"
/locus_tag="Rv0979A"
CDS 1094886..1095059
/codon_start=1
/transl_table=11
/gene="rpmF"
/locus_tag="Rv0979A"
/product="50S ribosomal protein L32 RpmF"
/note="Rv0979A, len: 57 aa. rpmF, 50S ribosomal protein
L32, similar to others e.g. rpmF|Q9RL50 probable 50S
ribosomal protein from Streptomyces coelicolor (56
aa),FASTA scores: E(): 5.1e-09, (63.45% identity in 52 aa
overlap); etc. Belongs to the L32P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv0979A"
/db_xref="EnsemblGenomes-Tr:CCP43729"
/db_xref="GOA:P9WH99"
/db_xref="InterPro:IPR002677"
/db_xref="InterPro:IPR011332"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH99"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43729.1"
/translation="MAVPKRRKSRSNTRSRRSQWKAAKTELVGVTVAGHAHKVPRRLL
KAARLGLIDFDKR"
gene complement(1095078..1096451)
/gene="PE_PGRS18"
/locus_tag="Rv0980c"
CDS complement(1095078..1096451)
/codon_start=1
/transl_table=11
/gene="PE_PGRS18"
/locus_tag="Rv0980c"
/product="PE-PGRS family protein PE_PGRS18"
/note="Rv0980c, (MTV044.08c), len: 457 aa.
PE_PGRS18,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002),highly similar to others e.g.
Z95387|MTCY1A10_19 from Mycobacterium tuberculosis (461
aa), FASTA score: (66.7% identity in 405 aa overlap);
Z95844|MTCY493_2 from Mycobacterium tuberculosis (741 aa),
FASTA score: (53.0% identity in 394 aa overlap); etc.
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv0980c"
/db_xref="EnsemblGenomes-Tr:CCP43730"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR001258"
/db_xref="InterPro:IPR011045"
/db_xref="InterPro:IPR011964"
/db_xref="InterPro:IPR013017"
/db_xref="InterPro:IPR015943"
/db_xref="UniProtKB/Swiss-Prot:Q79FU0"
/protein_id="CCP43730.1"
/translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAHD
EVSTAIAALFGSHGQHYQAISAQVAAYQERFVLALSQASSTYAVAEAASATPLQNVLD
AINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAG
LIGNGGAGGAGGQGLPFEAGANGGAGGAGGWLFGNGGAGGVGGAGGAGTTFGVAGGDG
GTGGVGGHGGLIGVGGHGGDGGTGGTGGAVSLARAGTAGGAGGGPAGGIGGAGGVGGA
GGAAGAVTTITHASFNDPHGVAVNPGGNIYVTNQGSNTVSVIDPVTNTVTGSITDGNG
PSGVAVSPVTGLVFVTNFDSNTVSVIDPNTNTVTGSIPVGTGAYGVAVNPGGNIYVTN
QFSNTVSVIDPATNTVTGSPIPVGLDPTGVAVNPVTGVVYVTNSLDDTVSVITGEPAR
SVCSAAI"
gene 1096822..1097508
/gene="mprA"
/locus_tag="Rv0981"
CDS 1096822..1097508
/codon_start=1
/transl_table=11
/gene="mprA"
/locus_tag="Rv0981"
/product="Mycobacterial persistence regulator MRPA (two
component response transcriptional regulatory protein)"
/note="Rv0981, (MTV044.09), len: 228 aa.
MprA,mycobacterial persistence regulator, a two-component
response regulator whose expression is required for
entrance into and maintenance of persistent infection (see
citation below), equivalent to NP_301250.1|NC_002677
putative two-component response regulator from
Mycobacterium leprae (228 aa); and highly similar to
others from Mycobacterium leprae. Also highly similar to
others e.g. AAG36759.1|AF119221_1|AF119221 response
regulator from Corynebacterium glutamicum (232 aa);
CAB88489.1|AL353816 putative two-component system response
regulator from Streptomyces coelicolor (248 aa);
BJY09666_1 two-component response regulator (ragA, ragB
and rpoH3) from B.japonicum (226 aa), FASTA score: (43.8%
identity in 224 aa overlap); BSAJ2571_44 two-component
response regulator from Bacillus subtilis (228 aa), FASTA
score: (46.4% identity in 224 aa overlap); etc. Also
highly similar to others from Mycobacterium tuberculosis
e.g. Rv1033c (257 aa); Rv0903c (236 aa), FASTA score:
(50.7 identity in 225 aa overlap); etc. Contains PS00217
Sugar transport proteins signature 2. Start changed since
first submission (-2 aa). MprAB is involved in the
regulation of genes in response to environmental stress
(See He et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv0981"
/db_xref="EnsemblGenomes-Tr:CCP43731"
/db_xref="GOA:P9WGM9"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="UniProtKB/Swiss-Prot:P9WGM9"
/inference="protein motif:PROSITE:PS00217"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43731.1"
/translation="MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDR
PDALVLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGADDYLPKP
FALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFAL
LEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRG
VGYVLRETPP"
gene 1097508..1099022
/gene="mprB"
/locus_tag="Rv0982"
CDS 1097508..1099022
/codon_start=1
/transl_table=11
/gene="mprB"
/locus_tag="Rv0982"
/product="Two component sensor kinase MprB"
/note="Rv0982, (MTV044.10), len: 504 aa. MprB, two
component sensor kinase, probable transmembrane protein
(see citation below), equivalent to
AL035500|MLCL373_16|NP_301251.1|NC_002677 putative
two-component system sensor kinase from Mycobacterium
leprae (519 aa), FASTA score: (81.0% identity in 521 aa
overlap). Also highly similar to others (especially in
C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221
sensor kinase from Corynebacterium glutamicum (455 aa);
CAB89748.1|AL354616 putative two-component histidine
kinase from Streptomyces coelicolor (481 aa);
X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa),
FASTA scores: opt: 451, E(): 4.2e-21, (36.0% identity in
303 aa overlap); P30847|BAES_ECOLI sensor protein from
Escherichia coli (467 aa), FASTA scores: opt: 412, E():
1.3e-18, (30.4% identity in 336 aa overlap); etc. Also
similar in C-terminal region to C-terminus of
Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis
(446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4
identity in 462 aa overlap). MprAB is involved in the
regulation of genes in response to environmental stress
(See He et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv0982"
/db_xref="EnsemblGenomes-Tr:CCP43732"
/db_xref="GOA:P9WGL1"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:P9WGL1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43732.1"
/translation="MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVY
AVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTA
QQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMN
KLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDE
LARLTEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRL
PKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRR
RNDILFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELV
VSDRGPGIPVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPG
GQPPGTSIYVLLPGRRMPIPQLPGATAGARSTDIENSRGSANVISVESQSTRAT"
gene 1099066..1100460
/gene="pepD"
/gene_synonym="mtb32b"
/locus_tag="Rv0983"
CDS 1099066..1100460
/codon_start=1
/transl_table=11
/gene="pepD"
/gene_synonym="mtb32b"
/locus_tag="Rv0983"
/product="Probable serine protease PepD (serine
proteinase) (MTB32B)"
/note="Rv0983, (MTV044.11), len: 464 aa. Probable pepD
(alternate gene name: mtb32b), secreted or membrane serine
protease (see citation below), equivalent (but longer 18
aa in N-terminus) to AL035500|MLCL373_17|T45448 probable
serine proteinase from Mycobacterium leprae (452 aa),
FASTA score: (74.2% identity in 466 aa overlap); and
highly similar to others from Mycobacterium leprae. Also
highly similar (except in N-terminus) to other proteases
e.g. CAC01350.1|AL390975 putative protease from
Streptomyces coelicolor (542 aa);
NP_440705.1|NC_000911|HtrA serine protease from
Synechocystis sp. (452 aa); NP_346646.1|NC_003028 serine
protease from Streptococcus pneumoniae (393 aa); etc. Also
similar in part to members of the htrA-antigen family e.g.
U87242|MTU87242_3|HtrA serine protease from M.
tuberculosis (542 aa), FASTA scores: opt: 846, E(): 2e-28,
(40.6% identity in 392 aa overlap); and similar to other
hypothetical serine proteases e.g. Rv0983, Rv0125, etc.
Belongs to the serine protease family. Conserved in M.
tuberculosis, M. leprae,M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0983"
/db_xref="EnsemblGenomes-Tr:CCP43733"
/db_xref="GOA:O53896"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR001940"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR036034"
/db_xref="PDB:1Y8T"
/db_xref="PDB:2Z9I"
/db_xref="UniProtKB/TrEMBL:O53896"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43733.1"
/translation="MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQT
YSQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGML
AIGAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVA
AKVVPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTF
SDGRTAPFTVVGADPTSDIAVVRVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEG
TVTTGIVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSA
IATLGADSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTLGA
KIVEVVAGGAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKAPGATVALTFQDPSG
GSRTVQVTLGKAEQ"
gene 1100460..1101005
/gene="moaB2"
/locus_tag="Rv0984"
CDS 1100460..1101005
/codon_start=1
/transl_table=11
/gene="moaB2"
/locus_tag="Rv0984"
/product="Possible pterin-4-alpha-carbinolamine
dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin
dehydratase) (pterin-4-a-carbinolamine dehydratase)
(phenylalanine hydroxylase-stimulating protein) (PHS)
(pterin carbinolamine dehydratase) (PCD)"
/note="Rv0984, (MTV044.12), len: 181 aa. Possible
moaB2,pterin-4-alpha-carbinolamine dehydratase, highly
similar to NP_301253.1|NC_002677 putative molybdenum
cofactor biosynthesis protein from Mycobacterium leprae
(181 aa),FASTA score: (92.3% identity in 181 aa overlap).
Also similar to others e.g. CAB59675.1|AL132674 molybdenum
cofactor biosynthesis protein from Streptomyces coelicolor
(179 aa); Q56208|MOCB_SYNP7 molybdenum cofactor
biosynthesis protein CB from Synechococcus sp. (319
aa),FASTA score: (37.3% identity in 142 aa overlap);
C-terminus of NP_197599.1|NC_003076 molybdopterin
biosynthesis CNX1 protein from Arabidopsis thaliana (670
aa); etc. Also similar to Rv0865|MOG from Mycobacterium
tuberculosis (160 aa); and other mog proteins e.g.
CAC39235.1|AJ312124 Mog protein from Eubacterium
acidaminophilum (162 aa). Could belong to the
pterin-4-alpha-carbinolamine dehydratase family.
Alternative start codon has been suggested in position
1100508."
/db_xref="EnsemblGenomes-Gn:Rv0984"
/db_xref="EnsemblGenomes-Tr:CCP43734"
/db_xref="GOA:O53897"
/db_xref="InterPro:IPR001453"
/db_xref="InterPro:IPR036425"
/db_xref="UniProtKB/TrEMBL:O53897"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43734.1"
/translation="MKVAAQCSKLGYTVAPMEQRAELVVGRALVVVVDDRTAHGDEDH
SGPLVTELLTEAGFVVDGVVAVSADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVT
PEATRDILDREILGIAEAIRASGLSAGIVDAGLSRGLAGVSGSTLVVNLAGSRYAVRD
GMATLNPLAAQIIGQLSSLEI"
gene complement(1101025..1101480)
/gene="mscL"
/locus_tag="Rv0985c"
CDS complement(1101025..1101480)
/codon_start=1
/transl_table=11
/gene="mscL"
/locus_tag="Rv0985c"
/product="Possible large-conductance ion mechanosensitive
channel MscL"
/note="Rv0985c, (MTV044.13c), len: 151 aa. Possible
mscL,large conductance mechanosensitive ion channel
(integral membrane protein) (see citations below,
equivalent to AL035500|MLCL373_19|NP_301254.1|NC_002677
putative mechanosensitive channel protein from
Mycobacterium leprae (154 aa), FASTA score: (71.0%
identity in 155 aa overlap). Also highly similar to others
e.g. NP_268999.1|NC_002737 putative large conductance
mechanosensitive channel from Streptococcus pyogenes (120
aa); CAB90974.1|AL355832 putative mechanosensitive channel
from Streptomyces coelicolor (156 aa); Q9X722|MSCL_CLOHI
large-conductance mechanosensitive channel from
Clostridium histolyticum (133 aa); Z83337|BSZ83337_6 large
conductance mechanosensitive channel from Bacillus
subtilis (130 aa), FASTA scores: opt: 248, E(): 8.4e-10,
(39.0% identity in 136 aa overlap); U08371|ECU08371_1
large conductance mechanosensitive channel from
Escherichia coli strain K-12 (136 aa), FASTA score: (36.6%
identity in 134 aa overlap); etc. Belongs to the MscL
family."
/db_xref="EnsemblGenomes-Gn:Rv0985c"
/db_xref="EnsemblGenomes-Tr:CCP43735"
/db_xref="GOA:P9WJN5"
/db_xref="InterPro:IPR001185"
/db_xref="InterPro:IPR019823"
/db_xref="InterPro:IPR036019"
/db_xref="InterPro:IPR037673"
/db_xref="PDB:2OAR"
/db_xref="PDB:6CTD"
/db_xref="UniProtKB/Swiss-Prot:P9WJN5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43735.1"
/translation="MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLIN
RIGVNAQSDVGILRIGIGGGQTIDLNVLLSAAINFFLIAFAVYFLVVLPYNTLRKKGE
VEQPGDTQVVLLTEIRDLLAQTNGDSPGRHGGRGTPSPTDGPRASTESQ"
gene 1101803..1102549
/locus_tag="Rv0986"
CDS 1101803..1102549
/codon_start=1
/transl_table=11
/locus_tag="Rv0986"
/product="Probable adhesion component transport
ATP-binding protein ABC transporter"
/note="Rv0986, (MTV044.14), len: 248 aa. Probable
ATP-binding protein ABC transporter supposedly involved in
transport of adhesion component (see citation
below),highly similar to many ATP-binding proteins e.g.
AE0010|AE001033_8 ABC transporter ATP-binding protein from
Archaeoglobus fulgidus (228 aa), FASTA scores: opt:
669,E(): 0, (45.7% identity in 219 aa overlap);
CAB81857.1|AL161691 putative ABC-transporter ATP-binding
protein from Streptomyces coelicolor (246 aa);
X84019|ZMDNAGRP_4 glutamate uptake regulatory protein
(grp) from Z.mobilis (232 aa), FASTA score: (44.4%
identity in 225 aa overlap); Z99111|BSUB0008_108 from
Bacillus subtilis (230 aa), FASTA score: (38.7% identity
in 222 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop), and PS00211 ABC transporters family
signature. Belongs to the ATP-binding transport protein
family (ABC transporters). Believed to have been acquired
by horizontal gene transfer (See Rosas-Magallanes et el.,
2006; Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0986"
/db_xref="EnsemblGenomes-Tr:CCP43736"
/db_xref="GOA:P9WQK1"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQK1"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/protein_id="CCP43736.1"
/translation="MNRQPIVQLSNLSWTFREGETRRQVLDHITFDFEPGEFVALLGQ
SGSGKSTLLNLISGIEKPTTGDVTINGFAITQKTERDRTLFRRDQIGIVFQFFNLIPT
LTVLENITLPQELAGVSQRKAAVVARDLLEKVGMADRERTFPDKLSGGEQQRVAISRA
LAHNPMLVLADEPTGNLDSDTGDKVLDVLLDLTRQAGKTLIMATHSPSMTQHADRVVN
LQGGRLIPAVNRENQTDQPASTILLPTSYE"
gene 1102542..1105109
/locus_tag="Rv0987"
CDS 1102542..1105109
/codon_start=1
/transl_table=11
/locus_tag="Rv0987"
/product="Probable adhesion component transport
transmembrane protein ABC transporter"
/note="Rv0987, (MTV044.15, MTCI237.01), len: 855 aa.
Probable transmembrane protein ABC transporter supposedly
involved in transport of adhesion component (see citation
below), whose N-terminus shows similarity with
hypothetical proteins, generally transmembrane proteins,
e.g. CAB96016.1|AL360055 putative ABC transport system
integral membrane protein from Streptomyces coelicolor
(855 aa); P44252|YCFU_HAEIN|HI1555 hypothetical protein
from Haemophilus influenzae (393 aa), FASTA scores: opt:
265,E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc.
N-and C-termini respectively show similarity to O32735
ATTF protein (420 aa), FASTA scores: E(): 1e-09, (26.7%
identity in 430 aa overlap), and G2340078 ATTG protein
(359 aa),FASTA scores: E(): 2.7e-08, (27.8% identity in
356 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop). Believed to have been acquired by
horizontal gene transfer (See Rosas-Magallanes et el.,
2006; Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv0987"
/db_xref="EnsemblGenomes-Tr:CCP43737"
/db_xref="GOA:O53900"
/db_xref="InterPro:IPR003838"
/db_xref="InterPro:IPR025857"
/db_xref="UniProtKB/TrEMBL:O53900"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43737.1"
/translation="MNDQAPVAYAPLWRTAWRRLRQRPFQYILLVLGIALGVAMIVAI
DVSSNSAQRAFDLSAAAITGKSTHRLVSGPAGVDQQLYVDLRRHGYDFSAPVIEGYVL
ARGLGNRAMQFMGTDPFAESAFRSPLWSNQNIAELGGFLTRPNGVVLSRQVAQKYGLA
VGDRIALQVKGAPTTVTLVGLLTPADEVSNQKLSDLIIADISTAQELFHMPGRLSHID
LIIKDEATATRIQQRLPAGVRMETSDTQRDTVKQMTDAFTVNLTALSLIALLVGIFLI
YNTVTFNVVQRRPFFAILRCLGVTREQLFWLIMTESLVAGLIGTGLGLLIGIWLGEGL
IGLVTQTINDFYFVINVRNVSVSAESLLKGLIIGIFAAMLATLPPAIEAMRTVPASTL
RRSSLESKITKLMPWLWVAWFGLGSFGVLMLWLPGNNLVVAFVGLFSVLIALALIAPP
LTRFVMLRLAPGLGRLLGPIGRMAPRNIVRSLSRTSIAIAALMMAVSLMVGVSISVGS
FRQTLANWLEVTLKSDVYVSPPTLTSGRPSGNLPVDAVRNISKWPGVRDAVMARYSSV
FAPDWGREVELMAVSGDISDGKRPYRWIDGNKDTLWPRFLAGKGVMLSEPMVSRQHLQ
MPPRPITLMTDSGPQTFPVLAVFSDYTSDQGVILMDRASYRAHWQDDDVTTMFLFLAS
GANSGALIDQLQAAFAGREDIVIQSTHSVREASMFIFDRSFTITIALQLVATVVAFIG
VLSALMSLELDRAHELGVFRAIGMTTRQLWKLMFIETGLMGGMAGLMALPTGCILAWI
LVRIINVRSFGWTLQMHFESAHFLRALLVAVVAALAAGMYPAWRLGRMTIRTAIREE"
gene 1105116..1106276
/locus_tag="Rv0988"
CDS 1105116..1106276
/codon_start=1
/transl_table=11
/locus_tag="Rv0988"
/product="Possible conserved exported protein"
/note="Rv0988, (MTCI237.02), len: 386 aa. Possible
conserved exported protein, with potential N-terminal
signal sequence, similar (except in N-terminus) to
O32737|L63540 ATTH protein from Agrobacterium tumefaciens
(355 aa), FASTA scores: opt: 651, E(): 5.7e-33, (33.4%
identity in 344 aa overlap); and NP_231265.1|NC_002505
conserved hypothetical protein from Vibrio cholerae (372
aa). Predicted to be an outer membrane protein (See Song
et al., 2008). Believed to have been acquired by
horizontal gene transfer (See Rosas-Magallanes et el.,
2006; Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0988"
/db_xref="EnsemblGenomes-Tr:CCP43738"
/db_xref="InterPro:IPR010791"
/db_xref="InterPro:IPR023374"
/db_xref="UniProtKB/TrEMBL:O86370"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43738.1"
/translation="MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDEN
NAGYSLATVPGAVRFPRDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPP
GEGVAIADASSWRTTQVYMAHFAISDISNRGFYPAEKFSRQALGLAGASSEPYAVWLD
DWYARESNNNSVQLFARTQNTVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLV
RQESRGTVSVNGDTFMVSGLSWKDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIR
QADGSVTRFSSGTFVAGDGGVIPLESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIG
LTLRGAALMANQELRLSRTYWEGAVALEGRYQGMPISGRGYVEMTGYVQRLS"
gene complement(1106405..1107382)
/gene="grcC2"
/locus_tag="Rv0989c"
CDS complement(1106405..1107382)
/codon_start=1
/transl_table=11
/gene="grcC2"
/locus_tag="Rv0989c"
/product="Probable polyprenyl-diphosphate synthase GrcC2
(polyprenyl pyrophosphate synthetase)"
/note="Rv0989c, (MTCI237.03c), len: 325 aa. Probable
grcC2,polyprenyl diphosphate synthetase, highly similar to
NP_302483.1|NC_002677 polyprenyl diphosphate synthase
component from Mycobacterium leprae (330 aa). Also similar
to others (generally hepta or hexaprenyl e.g.
NP_471378.1|NC_003212 protein similar to heptaprenyl
diphosphate synthase component II (menaquinone
biosynthesis) from Listeria innocua (321 aa);
NP_371994.1|NC_002758 heptaprenyl diphosphate syntase
component II from Staphylococcus aureus subsp. aureus Mu50
(319 aa); P55785|HEP2_BACST heptaprenyl diphosphate
synthase component from Bacillus subtilis (323 aa), FASTA
scores: opt: 496, E(): 1.4e-24, (31.4% identity in 306 aa
overlap); etc. Also highly similar to Mycobacterium
tuberculosis proteins e.g.
Rv0562|grcC1|NP_215076.1|MTCY25D10.41 probable
polyprenyl-diphosphate synthase (335 aa); Rv3383,
Rv3398c,Rv2173, etc. Seems to belong to the FPP/GGPP
synthetases family. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv0989c"
/db_xref="EnsemblGenomes-Tr:CCP43739"
/db_xref="GOA:O05572"
/db_xref="InterPro:IPR000092"
/db_xref="InterPro:IPR008949"
/db_xref="UniProtKB/TrEMBL:O05572"
/protein_id="CCP43739.1"
/translation="MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAH
LVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRK
TPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPA
SHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRD
IIAISGDSATLSGADLGQAVHTLPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTL
LRCSPGIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHAISACD"
gene complement(1107443..1108099)
/locus_tag="Rv0990c"
CDS complement(1107443..1108099)
/codon_start=1
/transl_table=11
/locus_tag="Rv0990c"
/product="Hypothetical protein"
/note="Rv0990c, (MTCI237.04c), len: 218 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv0990c"
/db_xref="EnsemblGenomes-Tr:CCP43740"
/db_xref="InterPro:IPR013974"
/db_xref="UniProtKB/TrEMBL:O05573"
/protein_id="CCP43740.1"
/translation="MAESSLNPSLVSRISAFLRPDWTRTVRARRFAAAGLVMLAGVAA
LRSNPEDDRSEVVVAAHDLRPGTALTPGDVRLEKRSATTLPDGSQADLDAVVGSTLAS
PTRRGEVLTDVRLLGSRLAESTAGPDARIVPLHLADSALVDLVRVGDVVDVLAAPVTD
SPAALRLLATDAIVVLVSAQQKAQAADSDRVVLVALPARLANTVAGAALGQTVTLTLH
"
gene complement(1108172..1108504)
/locus_tag="Rv0991c"
CDS complement(1108172..1108504)
/codon_start=1
/transl_table=11
/locus_tag="Rv0991c"
/product="Conserved serine rich protein"
/note="Rv0991c, (MTCI237.05c), len: 110 aa. Conserved
ser-rich protein (especially in C-terminus), highly
similar to N-terminus of NP_301255.1|NC_002677 conserved
hypothetical protein (Ser-rich C-terminus) from
Mycobacterium leprae (99 aa). Also highly similar to
SCE22.04|AB90971.1|AL355832 hypothetical protein from
Streptomyces coelicolor (110 aa); and similar to others."
/db_xref="EnsemblGenomes-Gn:Rv0991c"
/db_xref="EnsemblGenomes-Tr:CCP43741"
/db_xref="InterPro:IPR013429"
/db_xref="UniProtKB/TrEMBL:O05574"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43741.1"
/translation="MPTYSYECTQCANRFDVVQAFTDDALTTCERCSGRLRKLFNAVG
VVFKGTGFYRTDSRESGKKSKSQTNGSSTSESTKSSGSSGSSGSSESKASGSTEKSTS
STTAAAAV"
gene complement(1108578..1109171)
/locus_tag="Rv0992c"
CDS complement(1108578..1109171)
/codon_start=1
/transl_table=11
/locus_tag="Rv0992c"
/product="Conserved hypothetical protein"
/note="Rv0992c, (MTCI237.06c), len: 197 aa. Conserved
hypothetical protein, equivalent to NP_301256.1|NC_002677
conserved hypothetical protein from Mycobacterium leprae
(197 aa). Also similar, except in N-terminus, to other
hypothetical proteins and ligases e.g.
SCE87.34|CAB59679.1|AL132674 hypothetical protein from
Streptomyces coelicolor (204 aa); NP_461977.1|NC_003197
putative ligase from Salmonella typhimurium (182 aa);
P09160|YGFA_ECOLI hypothetical 21.1 kDa protein from
Escherichia coli (182 aa), FASTA scores: opt: 191, E():
1.1e-09, (29.5% identity in 146 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv0992c"
/db_xref="EnsemblGenomes-Tr:CCP43742"
/db_xref="GOA:O05575"
/db_xref="InterPro:IPR002698"
/db_xref="InterPro:IPR024185"
/db_xref="InterPro:IPR037171"
/db_xref="UniProtKB/TrEMBL:O05575"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43742.1"
/translation="MAMASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDS
TVCAYVPVGGEPGSIEMLDVLLRRAGRVLLPVARTAGGDLPLPLRWGEYRAGGLARAR
WGLLEPPEPWLPEAALAQASLVLVPALAVDRQGVRLGRGRGFYDRSLRCRDPHARLVA
VVRTVELVDVLPSEPHDVPMTHALTPERGLIALPCGE"
gene 1109272..1110192
/gene="galU"
/locus_tag="Rv0993"
CDS 1109272..1110192
/codon_start=1
/transl_table=11
/gene="galU"
/locus_tag="Rv0993"
/product="UTP--glucose-1-phosphate uridylyltransferase
GalU (UDP-glucose pyrophosphorylase) (UDPGP)
(alpha-D-glucosyl-1-phosphate uridylyltransferase)
(uridine diphosphoglucose pyrophosphorylase)"
/note="Rv0993, (MTCI237.07), len: 306 aa.
GalU,UTP--glucose-1-phosphate uridylyltransferase,
equivalent to AL035500|MLCL373_22 putative
UTP-glucose-1-phosphate uridylyltransferase from
Mycobacterium leprae (306 aa),FASTA score: (89.7% identity
in 302 aa overlap). Also highly similar to others e.g.
AB59678.1|AL132674 UTP-glucose-1-phosphate
uridylyltransferase from Streptomyces coelicolor (303 aa);
NP_244519.1|NC_002570 UTP-glucose-1-phosphate
uridylyltransferase from Bacillus halodurans (297 aa);
P25520|GALU_ECOLI|B1236|Z2012|ECS17
UTP--glucose-1-phosphate uridylyltransferase from
Escherichia coli strains K12 and O157:H7 (301 aa), FASTA
scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa
overlap); etc. Belongs to the prokaryotic UDPGP family."
/db_xref="EnsemblGenomes-Gn:Rv0993"
/db_xref="EnsemblGenomes-Tr:CCP43743"
/db_xref="GOA:O05576"
/db_xref="InterPro:IPR005771"
/db_xref="InterPro:IPR005835"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:O05576"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43743.1"
/translation="MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIE
LVAAEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRRAPALI
KVESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDDLVLPTGVLETMSKVRASRGG
TVLCAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLKVRGMVEKPKAETAPSRYAAAG
RYVLDRAIFDALRRIDQGAGGEVQLTDAIALLIAEGHPVHVVVHQGSRHDLGNPGGYL
KAAVDFALDRDDYGPDLRRWLVARLGLTEQ"
gene 1110269..1111549
/gene="moeA1"
/gene_synonym="moeA"
/locus_tag="Rv0994"
CDS 1110269..1111549
/codon_start=1
/transl_table=11
/gene="moeA1"
/gene_synonym="moeA"
/locus_tag="Rv0994"
/product="Probable molybdopterin biosynthesis protein
MoeA1"
/note="Rv0994, (MTCI237.08), len: 426 aa. Probable
moeA1,molybdenum cofactor biosynthesis protein, equivalent
to AL035500|MLCL373_23 putative molybdopterin biosynthesis
protein from Mycobacterium leprae (424 aa), FASTA score:
(88.3% identity in 426 aa overlap). Also highly similar to
many e.g. CAB59677.1|AL132674 molybdopterin biosynthesis
protein from Streptomyces coelicolor (424 aa);
NP_385769.1|NC_003047 probable molybdopterin biosynthesis
protein from Sinorhizobium meliloti (406 aa);
P12281|MOEA_ECOLI molybdopterin biosynthesis moea protein
from Escherichia coli (411 aa), FASTA scores: opt:
519,E(): 1.3e-24, (32.3% identity in 402 aa overlap); etc.
Also similar to MOEA2|Rv0438c|MTV037.02c probable
molybdopterin biosynthesis protein from Mycobacterium
tuberculosis (405 aa). Note that previously known as
moeA."
/db_xref="EnsemblGenomes-Gn:Rv0994"
/db_xref="EnsemblGenomes-Tr:CCP43744"
/db_xref="GOA:P9WJQ7"
/db_xref="InterPro:IPR001453"
/db_xref="InterPro:IPR005110"
/db_xref="InterPro:IPR005111"
/db_xref="InterPro:IPR036135"
/db_xref="InterPro:IPR036425"
/db_xref="InterPro:IPR036688"
/db_xref="InterPro:IPR038987"
/db_xref="UniProtKB/Swiss-Prot:P9WJQ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43744.1"
/translation="MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMP
GFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSR
LQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGD
VAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVN
SYALAAAGRDACAEVNRVGIVSNDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRS
VLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLS
LGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLL
ATLAEANCLVVVPTGAEQIRTGEIVDVAFLAQHG"
gene 1111612..1112223
/gene="rimJ"
/locus_tag="Rv0995"
CDS 1111612..1112223
/codon_start=1
/transl_table=11
/gene="rimJ"
/locus_tag="Rv0995"
/product="Ribosomal-protein-alanine acetyltransferase RimJ
(acetylating enzyme for N-terminal of ribosomal protein
S5)"
/note="Rv0995, (MTCI237.09), len: 203 aa.
RimJ,ribosomal-protein-alanine acetyltransferase. Contains
GNAT (Gcn5-related N-acetyltransferase) domain. See
Vetting et al. 2005. Equivalent to AL035500|MLCL373_24
probable acyltransferase from Mycobacterium leprae (218
aa), FASTA scores: (86.0% identity in 200 aa overlap).
Also similar to others and many acyltransferases e.g.
BAB69252.1|AB070946 possible acyltransferase from
Streptomyces avermitilis (156 aa); NP_385025.1|NC_003047
probable ribosomal-protein-alanine acetyltransferase from
Sinorhizobium meliloti (203 aa);
P09454|RIMJ_ECOLI|B1066|Z1703|ECS1444
ribosomal-protein-alanine acetyltransferase from
Escherichia coli strains K12 and O157:H7 (194 aa), FASTA
scores: opt: 247, E(): 1.5e-10, (26.9% identity in 186 aa
overlap). Belongs to the acetyltransferase family, RIMJ
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv0995"
/db_xref="EnsemblGenomes-Tr:CCP43745"
/db_xref="GOA:O05578"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:O05578"
/protein_id="CCP43745.1"
/translation="MAVGPLRVSAGVIRLRPVRMRDGVHWSRIRLADRAHLEPWEPSA
DGEWTVRHTVAAWPAVCSGLRSEARNGRMLPYVIELDGQFCGQLTIGNVTHGALRSAW
IGYWVPSAATGGGVATGALALGLDHCFGPVMLHRVEATVRPENAASRAVLAKVGFREE
GLLRRYLEVDRAWRDHLLMAITVEEVYGSVASTLVRAGHASWP"
gene 1112384..1113460
/locus_tag="Rv0996"
CDS 1112384..1113460
/codon_start=1
/transl_table=11
/locus_tag="Rv0996"
/product="Probable conserved transmembrane protein"
/note="Rv0996, (MTCI237.10), len: 358 aa. Probable
conserved transmembrane protein, equivalent to
AL035500|MLCL373_25 putative membrane protein from
Mycobacterium leprae (342 aa), FASTA scores: (66.4%
identity in 360 aa overlap). Contains possible signal
sequence and other hydrophobic domains. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0996"
/db_xref="EnsemblGenomes-Tr:CCP43746"
/db_xref="GOA:O05579"
/db_xref="UniProtKB/TrEMBL:O05579"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43746.1"
/translation="MPSIPQSLLWISLVVLWLFVLVPMLISKRDAVRRTSDVALATRV
LNGGAGARLLKRGGPAAGHRWGYLPPEGQGDDPDWKPEEDWRDDPVEDGFADVEHDID
EDQEADDARRRGAVVMKVAAPQTAGADEPDYLDVDVVEEDSEALPVGAGAAVGESADE
ADAEAADGVAGHADPEADPVEYEYEYEYVEDTCGLELEEDDQEAPPTVASGTSRRRRF
DTKTAAAVSARKYTFRKRALIVMAVILVGSAAAAFELTPVAWWICGSATGVTVLYLAY
LRRQTRIEEKVRRRRMQRIARARLGVENTRDREYDVVPSRLRRPGAVVLEIDDEDPIF
THLESAAPIRNYGWPRDLPRAVGQ"
gene 1113511..1113583
/gene="alaV"
tRNA 1113511..1113583
/gene="alaV"
/product="tRNA-Ala"
/anticodon=(pos:1113544..1113546,aa:Ala,seq:cgc)
/note="codon recognized: GCG; alaV, tRNA-Ala, anticodon
cgc, length = 73"
gene 1114293..1114724
/locus_tag="Rv0997"
CDS 1114293..1114724
/codon_start=1
/transl_table=11
/locus_tag="Rv0997"
/product="Hypothetical protein"
/note="Rv0997, (MTCI237.11), len: 143 aa. Hypothetical
unknown protein, equivalent to AAK45276.1 from
Mycobacterium tuberculosis strain CDC1551 (87 aa) but
longer 56 aa."
/db_xref="EnsemblGenomes-Gn:Rv0997"
/db_xref="EnsemblGenomes-Tr:CCP43747"
/db_xref="UniProtKB/TrEMBL:O05580"
/protein_id="CCP43747.1"
/translation="MAGIAGVDRDPPGWPQHSHLLAGDPERFRHQLQRAETTNSIECF
VAEWHHAGVAADMTRPWPTVVQGGAGQRRRRDVEPDRKTPVRWMSGQRLSEITWPTTD
IEHSVGAAEVQRHRGAVPLGSGGDAAGKVEGGRTPQPFVQP"
gene 1114748..1115749
/locus_tag="Rv0998"
CDS 1114748..1115749
/codon_start=1
/transl_table=11
/locus_tag="Rv0998"
/product="Conserved hypothetical protein"
/note="Rv0998, (MTCI237.12), len: 333 aa. Conserved
hypothetical protein, with cyclic nucleotide-binding
domain in N-terminal part and GNAT (Gcn5-related
N-acetyltransferase) domain in C-terminal part. See
Vetting et al. 2005. Possibly cyclic nucleotide-dependent
protein kinase, highly similar to NP_301261.1|NC_002677
conserved hypothetical protein from Mycobacterium leprae
(353 aa); and AL035500|MLCL373.38|T45457 hypothetical
protein from Mycobacterium leprae (143 aa), FASTA score:
(61.5% identity in 143 aa overlap). Also similar to many
hypothetical proteins and cyclic-NMP-dependent protein
kinases (generally at C-terminus) e.g. N-terminus of
SC9B10.09|T35878 hypothetical protein from Streptomyces
coelicolor (1039 aa); P05987|KAPR_DICDI camp-dependent
protein kinase regulatory chain from Dictyostelium
discoideum (327 aa), FASTA scores: opt: 177, E():
0.00036,(32.0% identity in 122 aa overlap);
NP_104403.1|NC_002678 hypothetical protein (contains
similarity to cAMP-dependent protein kinase regulatory
subunit) from Mesorhizobium loti (151 aa); etc. Contains
PS00889 Cyclic nucleotide-binding domain signature 2. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv0998"
/db_xref="EnsemblGenomes-Tr:CCP43748"
/db_xref="GOA:O05581"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016181"
/db_xref="InterPro:IPR018488"
/db_xref="InterPro:IPR018490"
/db_xref="PDB:4AVA"
/db_xref="PDB:4AVB"
/db_xref="PDB:4AVC"
/db_xref="UniProtKB/Swiss-Prot:O05581"
/inference="protein motif:PROSITE:PS00889"
/protein_id="CCP43748.1"
/translation="MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAG
QVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATV
TTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRP
VLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDP
VADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSD
NVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG"
gene 1115767..1116525
/locus_tag="Rv0999"
CDS 1115767..1116525
/codon_start=1
/transl_table=11
/locus_tag="Rv0999"
/product="Unknown protein"
/note="Rv0999, (MTCI237.13), len: 252 aa. Unknown protein.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv0999"
/db_xref="EnsemblGenomes-Tr:CCP43749"
/db_xref="GOA:O05582"
/db_xref="InterPro:IPR041313"
/db_xref="UniProtKB/TrEMBL:O05582"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43749.1"
/translation="MRPPLAPQFAADLLVKTVSTLRSSGAALGRLTTMRKAVLAVGSV
CWLVGCSSGASSTTASTGDIAKVAEVKSGFGPEYTVTDVTPRAIDPGFFSARKLPDGL
SFDPANCAQVAAGPQLPTGLQGNMAAVSAEGNGNRFVVIAVETSQPLPAPSPGKDCSK
VTFSGTQLRGGIEVVDVPHIDGTQTLGVHRVLQAVVGGSARTGELYDYSARFGDYQVI
VIANPLVIPGRPVARVDTQRARDLLVQAVAAVRG"
gene complement(1116531..1117148)
/locus_tag="Rv1000c"
CDS complement(1116531..1117148)
/codon_start=1
/transl_table=11
/locus_tag="Rv1000c"
/product="Conserved hypothetical protein"
/note="Rv1000c, len: 205 aa. Conserved hypothetical
protein, equivalent to ML0190|NP_301263.1|NC_002677
conserved hypothetical protein from Mycobacterium leprae
(205 aa). Also highly similar to
SC5F8.12c|CAB93740.1|AL357613 hypothetical protein from
Streptomyces coelicolor (210 aa), FASTA scores: E():
2.1e-45, (56.8% identity);
9106290|AAF84108.1|AE003963_5|NP_298588.1|NC_002488
protein described as DNA repair system specific for
alkylated DNA from Xylella fastidiosa (200 aa), FASTA
scores: E(): 3.4e-14, (38.55% identity); and similar in
C-terminus to other hypothetical proteins. Note that
replaces original Rv1000 predicted on other strand."
/db_xref="EnsemblGenomes-Gn:Rv1000c"
/db_xref="EnsemblGenomes-Tr:CCP43750"
/db_xref="GOA:L7N6A4"
/db_xref="InterPro:IPR005123"
/db_xref="InterPro:IPR027450"
/db_xref="InterPro:IPR032854"
/db_xref="InterPro:IPR037151"
/db_xref="UniProtKB/TrEMBL:L7N6A4"
/protein_id="CCP43750.1"
/translation="MCDKLGGVAIAVQGALFEHNERRQLGDGAFIDIRSGWLTGGEEL
LDALLSTVPWRAERRQMYDRVVDVPRLVSFHDLTIEDPPHPQLARMRRRLNDIYGGEL
GEPFTTAGLCYYRDGSDSVAWHGDTIGRGSTEDTMVAIVSLGATRVFALRPRGRGPSL
RLPLAHGDLLVMGGSCQRTFEHAVPKTSAPTGPRVSIQFRPRDVR"
gene 1117185..1118393
/gene="arcA"
/locus_tag="Rv1001"
CDS 1117185..1118393
/codon_start=1
/transl_table=11
/gene="arcA"
/locus_tag="Rv1001"
/product="Probable arginine deiminase ArcA (adi) (ad)
(arginine dihydrolase)"
/note="Rv1001, (MTCI237.16), len: 402 aa. Probable
arcA,arginine deiminase, similar to e.g. ARCA_PSEAE|P13981
arginine deiminase (417 aa), fasta scores: opt: 581, E():
1.4e-31, (39.4% identity in 411 aa overlap); also similar
to SAGP_STRPY|P16962 streptococcal acid glycoprotein (410
aa), FASTA scores, opt: 823, E():0, (38.3% identity in 402
aa overlap). Belongs to the arginine deiminase family."
/db_xref="EnsemblGenomes-Gn:Rv1001"
/db_xref="EnsemblGenomes-Tr:CCP43751"
/db_xref="GOA:P9WQ05"
/db_xref="InterPro:IPR003876"
/db_xref="UniProtKB/Swiss-Prot:P9WQ05"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43751.1"
/translation="MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPW
VSRAQDEHDEFAELLASRGAEVLLLSDLLTEALHHSGAARMQGIAAAVDAPRLGLPLA
QELSAYLRSLDPGRLAHVLTAGMTFNELPSDTRTDVSLVLRMHHGGDFVIEPLPNLVF
TRDSSIWIGPRVVIPSLALRARVREASLTDLIYAHHPRFTGVRRAYESRTAPVEGGDV
LLLAPGVVAVGVGERTTPAGAEALARSLFDDDLAHTVLAVPIAQQRAQMHLDTVCTMV
DTDTMVMYANVVDTLEAFTIQRTPDGVTIGDAAPFAEAAAKAMGIDKLRVIHTGMDPV
VAEREQWDDGNNTLALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSELGTGRGGPRC
MSCPAARDPL"
gene complement(1118428..1119939)
/locus_tag="Rv1002c"
CDS complement(1118428..1119939)
/codon_start=1
/transl_table=11
/locus_tag="Rv1002c"
/product="Conserved membrane protein"
/note="Rv1002c, (MTCI237.17c), len: 503 aa. Conserved
membrane protein. Predicted to be in the GT-C superfamily
of glycosyltransferases (See Liu and Mushegian, 2003).
Similar to AL132674|SCE87.05 hypothetical protein from
Streptomyces coelicolor (591 aa), FASTA scores: opt:
666,E(): 0, (39.0% identity in 546 aa overlap); weakly
similar and to TSCC_PSEAM|P55019 thiazide-sensitive
sodium-chloride cotransporter from Pseudopleuronectes
americanus (1023 aa),FASTA scores: opt: 44, E(): 4.2e-06,
(22.4% identity in 326 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1002c"
/db_xref="EnsemblGenomes-Tr:CCP43752"
/db_xref="GOA:P9WN05"
/db_xref="InterPro:IPR003342"
/db_xref="InterPro:IPR027005"
/db_xref="InterPro:IPR032421"
/db_xref="UniProtKB/Swiss-Prot:P9WN05"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43752.1"
/translation="MVPVVSPGPLVPVADFGPLDRLRGWIVTGLITLLATVTRFLNLG
SLTDAGTPIFDEKHYAPQAWQVLNNHGVEDNPGYGLVVHPPVGKQLIAIGEAIFGYNG
FGWRFTGALLGVVLVALVVRIVRRISRSTLVGAIAGVLLICDGVSFVTARTALLDGFL
TFFVVAAFGALIVDRDQVRERMHIALLAGRSAATVWGPRVGVRWWRFGAGVLLGLACA
TKWSGVYFVLFFGAMALAFDVAARRQYQVQRPWLGTVRRDVLPSGYALGLIPFAVYLA
TYAPWFASETAIDRHAVGQAVGRNSVVPLPDAVRSLWHYTAKAFHFHAGLTNSAGNYH
PWESKPWTWPMSLRPVLYAIDQQDVAGCGAQSCVKAEMLVGTPAMWWLAVPVLAYAGW
RMFVRRDWRYAVVLVGYCAGWLPWFADIDRQMYFFYAATMAPFLVMGISLVLGDILYH
PGQGSERRTLGLIVVCCYVALVVTNFAWLYPVLTGLPISQQTWNLEIWLPSWR"
gene 1120022..1120879
/locus_tag="Rv1003"
CDS 1120022..1120879
/codon_start=1
/transl_table=11
/locus_tag="Rv1003"
/product="Conserved protein"
/note="Rv1003, (MTCI237.19), len: 285 aa. Conserved
protein, similar to others e.g. AL132674|SCE87.04
Streptomyces coelicolor (286 aa), FASTA scores: opt:
877,E(): 0, (53.2% identity in 280 aa overlap); and
YRAL_ECOLI|P45528 hypothetical 31.3 kd protein (286
aa),FASTA scores: opt: 561, E(): 4.4e-27, (36.9% identity
in 279 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1003"
/db_xref="EnsemblGenomes-Tr:CCP43753"
/db_xref="GOA:P9WGW7"
/db_xref="InterPro:IPR000878"
/db_xref="InterPro:IPR008189"
/db_xref="InterPro:IPR014776"
/db_xref="InterPro:IPR014777"
/db_xref="InterPro:IPR018063"
/db_xref="InterPro:IPR035996"
/db_xref="UniProtKB/Swiss-Prot:P9WGW7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43753.1"
/translation="MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKL
AKALDIRIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLVAA
CIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWLAELAEERRTC
VFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVVRGSLDELAIWAAGGVLGE
ITVVVAGAAPHAELSSLIAQVEEFVAAGIRVKDACSEVAAAHPGVRTRQLYDAVLQSR
RETGGPAQP"
gene complement(1120889..1122148)
/locus_tag="Rv1004c"
CDS complement(1120889..1122148)
/codon_start=1
/transl_table=11
/locus_tag="Rv1004c"
/product="Probable membrane protein"
/note="Rv1004c, (MTCI237.20c), len: 419 aa. Probable
membrane protein. Contains repetitive sequences, which
have similarities with elastin, and possible N-terminal
signal sequence."
/db_xref="EnsemblGenomes-Gn:Rv1004c"
/db_xref="EnsemblGenomes-Tr:CCP43754"
/db_xref="GOA:O05589"
/db_xref="UniProtKB/TrEMBL:O05589"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43754.1"
/translation="MSISCRVREGFVMRLAIVGTAAAAAIGGTLAVAPLTLSTPERVA
GGTCSAGQQCDRLAAVLMPDTATPSGPAAAEHAVPAPFEPVADTIAPGLVPRPGVPAA
AAVPRVGPPAVPGLPNIPGAAGPALPPPPALPNLAAPSVPGVGIPGIGIPGIGIPGIG
IPGVPDPITGVNTAAAVVNGVLGVGGTAAGVVTASAVAVTYLVLAVNALESSGILPTA
RGTASTVASLLLPGAQSAAAALPAVGLPALPGVTPASLLAMAAAAGLPGVGFPSLPGV
SPTDLMAMAAAAGLPTSLPGLAGMSPAELTALVAGGLPMLAAAGLPAGLAGVDPATLA
AALPALAAGGLPPGLPALPGVDPAALAAALPALAAGLPALPAGLPPLPAVPALPAPPP
LPGPPPLPALPSRLCTPGFGPIGVCIP"
gene complement(1122222..1123598)
/gene="pabB"
/locus_tag="Rv1005c"
CDS complement(1122222..1123598)
/codon_start=1
/transl_table=11
/gene="pabB"
/locus_tag="Rv1005c"
/product="Probable para-aminobenzoate synthase component I
PABD"
/note="Rv1005c, (MTCI237.22c), len: 458 aa (Start-site not
certain). Probable PabD, para-aminobenzoate synthase
component I. Similar to PABB_ECOLI|P05041
para-aminobenzoate synthase component I from Escherichia
coli (453 aa), FASTA scores: opt: 589, E(): 1.8e-27,
(40.7% identity in 268 aa overlap). Similar to M.
tuberculosis Rv1609, Rv3215, Rv2386c."
/db_xref="EnsemblGenomes-Gn:Rv1005c"
/db_xref="EnsemblGenomes-Tr:CCP43755"
/db_xref="GOA:O05591"
/db_xref="InterPro:IPR005801"
/db_xref="InterPro:IPR005802"
/db_xref="InterPro:IPR015890"
/db_xref="InterPro:IPR019999"
/db_xref="UniProtKB/TrEMBL:O05591"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43755.1"
/translation="MNLAWELSTRTKSPRSHLRCENPQFCQARTVRIDRLGDLGGAPA
VLRAVGRATSRLDLPPPAALTGEWFGALAVIAPSVSIQPVSGDDVFSGPPGTGGPDAT
GAVGGGWVGYLSYPDAGADGRPHRIPEAAGGWTDCVLRRDRDGQWWYESLSGAPIADW
LASALATTRASVARPAPACRIDWEPADRAAHRDGVLACLEAIGAGEVYQACVCTQFAG
TVTGSPLDFFIDGFGRTAPSRSAFVAGPWGAVASLSPELFLRRRGSVVTSSPIKGTLP
LDAPPSALRASAKEVAENIMIVDLVRNDLGRVAVTGTVTVPELLVVRPAPGVWHLVST
VSARVPLEEPMSALLDAAFPPASVTGTPKLRARQLISQWERYRRGIYCGTVGLASPVA
GCELNVAIRTVEFDTAGNAVLGVGGGITADSDPDAEWAECLHKAAPIVGLPAATRTTP
ARLASKVR"
gene 1123714..1125417
/locus_tag="Rv1006"
CDS 1123714..1125417
/codon_start=1
/transl_table=11
/locus_tag="Rv1006"
/product="Unknown protein"
/note="Rv1006, (MTCI237.23), len: 567 aa. Unknown protein.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1006"
/db_xref="EnsemblGenomes-Tr:CCP43756"
/db_xref="GOA:O05592"
/db_xref="InterPro:IPR017853"
/db_xref="UniProtKB/TrEMBL:O05592"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43756.1"
/translation="MVLRSRKSTLGVVVCLALVLGGPLNGCSSSASHRGPLNAMGSPA
IPSTAQEIPNPLRGQYEDLMEPLFPQGNPAQQRYPPWPASYDASLRVSWRQLQPTDPR
TLPPDAPDDRKYDFSVIDNALTRLADRGMRLTLRVYAYSSCCKASYPDGTNIAIPDWE
RAIASTNTSYPGPATDPSTGVVQVVPNFNDSTYLNDFAQLLAALGRRYDGDERLSVFE
FSGYGDFSENHVAYLRDTLGAPGPGPDESVATLGYYSQFRDQNITTASIKQLIAANVS
AFPHTQLVTSPANPEIVRELFADEVTNKLAAPVGVRSDCLGVDAPLPAWAESSTSHYV
QTKDPVVAALRQRLATAPVITEWCELPTGSSPRAYYEKGLRDVIRYHVSMTSSVNFPD
QTATSPMDPALYLVWAQANAAAGYRYSVEAQPGSQALAGKVATISVTWTNYGAAAATE
KWVPGYRLVDSTGQVVRTLPAAVDLKTLVSDQRGDRSSDQPTPASVAETVRVDLSGLP
AGHYTLRAAIDWQQHKPNGSHVVNYPPMLLSRDGRDDSGFYPVATLDIPRDAQTAVNA
S"
gene complement(1125444..1127003)
/gene="metS"
/locus_tag="Rv1007c"
CDS complement(1125444..1127003)
/codon_start=1
/transl_table=11
/gene="metS"
/locus_tag="Rv1007c"
/product="Methionyl-tRNA synthetase MetS (MetRS)
(methionine--tRNA ligase)"
/note="Rv1007c, (MTCI237.24), len: 519 aa. metS
(MetG),methionyl-tRNA synthetase, similar to many e.g.
SYM_BACSU|P37465 methionyl-tRNA synthetase from Bacillus
subtilus (664 aa), FASTA scores: opt: 1506, E(): 0, (44.9%
identity in 492 aa overlap); similar to other
Mycobacterium tuberculosis tRNA synthases e.g. Rv2448c,
Rv1536, Rv0041. Contains PS00178 Aminoacyl-transfer RNA
synthetases class-I signature. Belongs to class-I
aminoacyl-tRNA synthetase family. Strong, to
cysteinyl-tRNA synthetase."
/db_xref="EnsemblGenomes-Gn:Rv1007c"
/db_xref="EnsemblGenomes-Tr:CCP43757"
/db_xref="GOA:P9WFU5"
/db_xref="InterPro:IPR001412"
/db_xref="InterPro:IPR009080"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR014758"
/db_xref="InterPro:IPR015413"
/db_xref="InterPro:IPR023457"
/db_xref="InterPro:IPR033911"
/db_xref="InterPro:IPR041872"
/db_xref="PDB:6AX8"
/db_xref="UniProtKB/Swiss-Prot:P9WFU5"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43757.1"
/translation="MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRF
LTGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEA
SKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQ
TYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVP
EHPDHVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFL
MSAGIELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQ
DGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATAD
GLLERVRGHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLY
VTCEVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFP
RYQPPQPPEGK"
gene 1127089..1127883
/gene="tatD"
/gene_synonym="yjjV"
/locus_tag="Rv1008"
CDS 1127089..1127883
/codon_start=1
/transl_table=11
/gene="tatD"
/gene_synonym="yjjV"
/locus_tag="Rv1008"
/product="Probable deoxyribonuclease TatD (YJJV protein)"
/note="Rv1008, (MTCI237.25), len: 264 aa. Probable tatD
(alternate gene name: yjjV), deoxyribonuclease, component
of twin arginine translocation protein export system (see
citations below). Similar to many members of the
YBL055C/YJJV family e.g. YCFH_ECOLI|P37346 Putative
deoxyribonuclease ycfH (265 aa), fasta scores: opt:
487,E(): 1.4e-24, (36.7% identity in 270 aa overlap). Also
similar to P37545|YABD_BACSU Putative deoxyribonuclease
yabD (255 aa), FASTA scores: opt: 599, E(): 7.7e-33,
(40.1% identity in 262 aa overlap). Contains PS01137
Hypothetical YBL055c/yjjV family signature 1, and PS01091
Hypothetical YBL055c/yjjV family signature 3."
/db_xref="EnsemblGenomes-Gn:Rv1008"
/db_xref="EnsemblGenomes-Tr:CCP43758"
/db_xref="GOA:O08343"
/db_xref="InterPro:IPR001130"
/db_xref="InterPro:IPR015991"
/db_xref="InterPro:IPR018228"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/Swiss-Prot:O08343"
/inference="protein motif:PROSITE:PS01137"
/inference="protein motif:PROSITE:PS01091"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43758.1"
/translation="MVDAHTHLDACGARDADTVRSLVERAAAAGVTAVVTVADDLESA
RWVTRAAEWDRRVYAAVALHPTRADALTDAARAELERLVAHPRVVAVGETGIDMYWPG
RLDGCAEPHVQREAFAWHIDLAKRTGKPLMIHNRQADRDVLDVLRAEGAPDTVILHCF
SSDAAMARTCVDAGWLLSLSGTVSFRTARELREAVPLMPVEQLLVETDAPYLTPHPHR
GLANEPYCLPYTVRALAELVNRRPEEVALITTSNARRAYGLGWMRQ"
gene 1128091..1129179
/gene="rpfB"
/locus_tag="Rv1009"
CDS 1128091..1129179
/codon_start=1
/transl_table=11
/gene="rpfB"
/locus_tag="Rv1009"
/product="Probable resuscitation-promoting factor RpfB"
/note="Rv1009, (MTCI237.26), len: 362 aa. Probable
rpfB,resuscitation-promoting factor (see citation
below),similar to others from Mycobacterium tuberculosis:
Rv2450c|MTV008.06c|RPFE probable resuscitation-promoting
factor (172 aa), FASTA scores: E(): 1.9e-19, (42.9%
identity in 147 aa overlap); Rv0867c|RPFA,
Rv1884c|RPFC,and Rv2389c|RPFD. Possible lipoprotein;
contains PS00013 Prokaryotic membrane lipoprotein lipid
attachment site. Interacts with RipA (see Hett et al.,
2007). Predicted possible vaccine candidate (See Zvi et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1009"
/db_xref="EnsemblGenomes-Tr:CCP43759"
/db_xref="GOA:P9WG29"
/db_xref="InterPro:IPR007137"
/db_xref="InterPro:IPR010618"
/db_xref="InterPro:IPR011098"
/db_xref="InterPro:IPR023346"
/db_xref="PDB:1XSF"
/db_xref="PDB:3EO5"
/db_xref="PDB:4EMN"
/db_xref="PDB:4KL7"
/db_xref="PDB:4KPM"
/db_xref="PDB:5E27"
/db_xref="UniProtKB/Swiss-Prot:P9WG29"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43759.1"
/translation="MLRLVVGALLLVLAFAGGYAVAACKTVTLTVDGTAMRVTTMKSR
VIDIVEENGFSVDDRDDLYPAAGVQVHDADTIVLRRSRPLQISLDGHDAKQVWTTAST
VDEALAQLAMTDTAPAAASRASRVPLSGMALPVVSAKTVQLNDGGLVRTVHLPAPNVA
GLLSAAGVPLLQSDHVVPAATAPIVEGMQIQVTRNRIKKVTERLPLPPNARRVEDPEM
NMSREVVEDPGVPGTQDVTFAVAEVNGVETGRLPVANVVVTPAHEAVVRVGTKPGTEV
PPVIDGSIWDAIAGCEAGGNWAINTGNGYYGGVQFDQGTWEANGGLRYAPRADLATRE
EQIAVAEVTRLRQGWGAWPVCAARAGAR"
gene 1129152..1130105
/gene="ksgA"
/locus_tag="Rv1010"
CDS 1129152..1130105
/codon_start=1
/transl_table=11
/gene="ksgA"
/locus_tag="Rv1010"
/product="Probable dimethyladenosine transferase KsgA
(S-adenosylmethionine-6-N', N'-adenosyl(rRNA)
dimethyltransferase) (16S rRNA dimethylase) (high level
kasugamycin resistance protein KsgA) (kasugamycin
dimethyltransferase)"
/note="Rv1010, (MTCI237.27), len: 317 aa. Probable
ksgA,dimethyladenosine transferase, similar to many e.g.
KSGA_BACSU|P37468 dimethyladenosine transferase from
Bacillus subtilus (292 aa), FASTA scores: opt: 524, E():
1.5e-28, (37.2% identity in 274 aa overlap); similar to
Mycobacterium tuberculosis hypothetical protein Rv1988.
Contains PS01131 Ribosomal RNA adenine dimethylases
signature."
/db_xref="EnsemblGenomes-Gn:Rv1010"
/db_xref="EnsemblGenomes-Tr:CCP43760"
/db_xref="GOA:P9WH07"
/db_xref="InterPro:IPR001737"
/db_xref="InterPro:IPR011530"
/db_xref="InterPro:IPR020596"
/db_xref="InterPro:IPR020598"
/db_xref="InterPro:IPR023165"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WH07"
/inference="protein motif:PROSITE:PS01131"
/protein_id="CCP43760.1"
/translation="MCCTSGCALTIRLLGRTEIRRLAKELDFRPRKSLGQNFVHDANT
VRRVVAASGVSRSDLVLEVGPGLGSLTLALLDRGATVTAVEIDPLLASRLQQTVAEHS
HSEVHRLTVVNRDVLALRREDLAAAPTAVVANLPYNVAVPALLHLLVEFPSIRVVTVM
VQAEVAERLAAEPGSKEYGVPSVKLRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRY
ETSPWPTDDAFRRRVFELVDIAFAQRRKTSRNAFVQWAGSGSESANRLLAASIDPARR
GETLSIDDFVRLLRRSGGSDEATSTGRDARAPDISGHASAS"
gene 1130191..1131111
/gene="ispE"
/locus_tag="Rv1011"
CDS 1130191..1131111
/codon_start=1
/transl_table=11
/gene="ispE"
/locus_tag="Rv1011"
/product="Probable 4-diphosphocytidyl-2-C-methyl-D-
erythritol kinase IspE (CMK)
(4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol
kinase)"
/note="Rv1011, (MTCI237.28, MT1040), len: 306 aa. Probable
ispE, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
,similar to others e.g. Q9K3R6|ISPE_STRCO Streptomyces
coelicolor (299 aa), FASTA scores: opt: 925, E():
2.7e-49,(54.5% identity in 297 overlap); etc. Belongs to
the ISPE family."
/db_xref="EnsemblGenomes-Gn:Rv1011"
/db_xref="EnsemblGenomes-Tr:CCP43761"
/db_xref="GOA:P9WKG7"
/db_xref="InterPro:IPR004424"
/db_xref="InterPro:IPR006204"
/db_xref="InterPro:IPR013750"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR036554"
/db_xref="PDB:3PYD"
/db_xref="PDB:3PYE"
/db_xref="PDB:3PYF"
/db_xref="PDB:3PYG"
/db_xref="UniProtKB/Swiss-Prot:P9WKG7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43761.1"
/translation="MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEV
TVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGG
MAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELA
TVLSRNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQL
APLLGNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGA
QLSGAGVCRTVRVATGPVPGARVVSAPTEV"
gene 1131128..1131421
/locus_tag="Rv1012"
CDS 1131128..1131421
/codon_start=1
/transl_table=11
/locus_tag="Rv1012"
/product="Hypothetical protein"
/note="Rv1012, (MTCI237.29), len: 97 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1012"
/db_xref="EnsemblGenomes-Tr:CCP43762"
/db_xref="UniProtKB/TrEMBL:O05597"
/protein_id="CCP43762.1"
/translation="MPRAARGIRACRGRWVDRLAHQHASGRAAGIRPREVGGAHQSQA
QKPYHDATEPLGESLRYRPAHGDSCINGHRDNPSARESSQFTAGSTAKAVTKL"
gene 1131625..1133259
/gene="pks16"
/locus_tag="Rv1013"
CDS 1131625..1133259
/codon_start=1
/transl_table=11
/gene="pks16"
/locus_tag="Rv1013"
/product="Putative polyketide synthase Pks16"
/note="Rv1013, (MTCI237.30-MTCY10G2.36c), len: 544 aa.
Putative pks16, polyketide synthase, similar to many e.g.
N-terminus of Q50857|U24657 saframycin MX1 synthetase B
(1770 aa), FASTA scores: opt: 526, E(): 1.4e-25, (29.3%
identity in 542 aa overlap); etc. Contains PS00455
Putative AMP-binding domain signature. Belongs to the
ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv1013"
/db_xref="EnsemblGenomes-Tr:CCP43763"
/db_xref="GOA:O05598"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR028154"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:O05598"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43763.1"
/translation="MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAG
GLAAAGVGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDTMT
VIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVGEDDLALMQLT
SGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSWLPCFHDMGMVGFLTIPMF
FGAELVKVTPMDFLRDTLLWAKLIDKYQGTMTAAPNFAYALLAKRLRRQAKPGDFDLS
TLRFALSGAEPVEPADVEDLLDAGKPFGLRPSAILPAYGMAETTLAVSFSECNAGLVV
DEVDADLLAALRRAVPATKGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELR
GESLTPGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYPT
DIERAAGRVDGVRPGCAVAVRLDAGHSRESFAVAVESNAFEDPAEVRRIEHQVAHEVV
AEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTLVT"
gene complement(1133333..1133908)
/gene="pth"
/locus_tag="Rv1014c"
CDS complement(1133333..1133908)
/codon_start=1
/transl_table=11
/gene="pth"
/locus_tag="Rv1014c"
/product="Probable peptidyl-tRNA hydrolase Pth"
/note="Rv1014c, (MTCY10G2.35), len: 191 aa. Probable
pth,peptidyl-tRNA hydrolase, similar to PTH_ECOLI|P23932
peptidy l-trna hydrolase from Escherichia coli (194
aa),FASTA scores: opt: 472, E(): 2.3e-25, (39.6% identity
in 187 aa overlap). Belongs to the PTH family."
/db_xref="EnsemblGenomes-Gn:Rv1014c"
/db_xref="EnsemblGenomes-Tr:CCP43764"
/db_xref="GOA:P9WHN7"
/db_xref="InterPro:IPR001328"
/db_xref="InterPro:IPR018171"
/db_xref="InterPro:IPR036416"
/db_xref="PDB:2JRC"
/db_xref="PDB:2Z2I"
/db_xref="PDB:2Z2J"
/db_xref="PDB:2Z2K"
/db_xref="PDB:3TCK"
/db_xref="PDB:3TCN"
/db_xref="PDB:3TD2"
/db_xref="PDB:3TD6"
/db_xref="UniProtKB/Swiss-Prot:P9WHN7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43764.1"
/translation="MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHK
RSGAEVATGRSAGRSLVLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFG
RIRLKIGGGEGGHNGLRSVVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERA
EVPTICEQAADATELLIEQGMEPAQNRVHAW"
gene complement(1133921..1134568)
/gene="rplY"
/locus_tag="Rv1015c"
CDS complement(1133921..1134568)
/codon_start=1
/transl_table=11
/gene="rplY"
/locus_tag="Rv1015c"
/product="50S ribosomal protein L25 RplY"
/note="Rv1015c, (MTCY10G2.34), len: 215 aa. rplY, 50s
ribosomal protein L25, similar to RL25_ECOLI|P02426 50s
ribosomal protein L25 from Escherichia coli (94 aa), FASTA
scores: opt: 182, E(): 2.5e-05, (38.4% identity in 86 aa
overlap) and to CTC_BACSU|P14194 general stress protein
from Bacillus subtilis (203 aa), FASTA scores: opt:
260,E(): 1.4e-09, (28.4% identity in 201 aa overlap).
Belongs to the L25P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv1015c"
/db_xref="EnsemblGenomes-Tr:CCP43765"
/db_xref="GOA:P9WHB5"
/db_xref="InterPro:IPR001021"
/db_xref="InterPro:IPR011035"
/db_xref="InterPro:IPR020056"
/db_xref="InterPro:IPR020057"
/db_xref="InterPro:IPR029751"
/db_xref="InterPro:IPR037121"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43765.1"
/translation="MAKSASNQLRVTVRTETGKGASRRARRAGKIPAVLYGHGAEPQH
LELPGHDYAAVLRHSGTNAVLTLDIAGKEQLALTKALHIHPIRRTIQHADLLVVRRGE
KVVVEVSVVVEGQAGPDTLVTQETNSIEIEAEALSIPEQLTVSIEGAEPGTQLTAGQI
ALPAGVSLISDPDLLVVNVVKAPTAEELEGEVAGAEEAEEAAVEAGEAEAAGESE"
gene complement(1134785..1135465)
/gene="lpqT"
/locus_tag="Rv1016c"
CDS complement(1134785..1135465)
/codon_start=1
/transl_table=11
/gene="lpqT"
/locus_tag="Rv1016c"
/product="Probable conserved lipoprotein LpqT"
/note="Rv1016c, (MTCY10G2.33), len: 226 aa. Probable
lpqT,conserved lipoprotein. Similar to several
Mycobacterium tuberculosis hypothetical proteins e.g.
Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA antigen (310
aa), FASTA scores: opt: 329, E(): 2e-17, (32.3% identity
in 229 aa overlap); Rv0583c. Contains PS00013 Prokaryotic
membrane lipoprotein lipid attachment site. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1016c"
/db_xref="EnsemblGenomes-Tr:CCP43766"
/db_xref="GOA:P9WK59"
/db_xref="InterPro:IPR019674"
/db_xref="UniProtKB/Swiss-Prot:P9WK59"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43766.1"
/translation="MAGRRCPQDSVRPLAVAVAVATLAMSAVACGPKSPDFQSILSTS
PTTSAVSTTTEVPVPLWKYLESVGVTGEPVAPSSLTDLTVSIPTPPGWAPMKNPNITP
NTEMIAKGESYPTAMLMVFKLHRDFDIAEALKHGTADARLSTNFTELDSSTADFNGFP
SSMIQGSYDLHGRRLHTWNRIVFPTGAPPAKQRYLVQLTITSLANEAVKHASDIEAII
AGFVVAAK"
gene complement(1135501..1136481)
/gene="prsA"
/locus_tag="Rv1017c"
CDS complement(1135501..1136481)
/codon_start=1
/transl_table=11
/gene="prsA"
/locus_tag="Rv1017c"
/product="Probable ribose-phosphate pyrophosphokinase PrsA
(phosphoribosyl pyrophosphate synthetase) (PRPP
synthetase)"
/note="Rv1017c, (MTCY10G2.32), len: 326 aa. Probable
prsA,ribose-phosphate pyrophosphokinase, highly similar to
others e.g. KPRS_ECOLI|P08330 ribose-phosphate
pyrophosphokinase from Escherichia coli (314 aa), FASTA
scores: opt: 826, E(): 0, (43.8% identity in 317 aa
overlap). Contains PS00103 Purine/pyrimidine
phosphoribosyl transferases signature; contains PS00144
Asparaginase / glutaminase active site signature 1.
Belongs to the ribose-phosphate pyrophosphokinase family.
Cofactor: both inorganic phosphate and magnesium ion are
required for enzyme stability and activity (by
similarity)."
/db_xref="EnsemblGenomes-Gn:Rv1017c"
/db_xref="EnsemblGenomes-Tr:CCP43767"
/db_xref="GOA:P9WKE3"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR000842"
/db_xref="InterPro:IPR005946"
/db_xref="InterPro:IPR029057"
/db_xref="InterPro:IPR029099"
/db_xref="InterPro:IPR037515"
/db_xref="UniProtKB/Swiss-Prot:P9WKE3"
/inference="protein motif:PROSITE:PS00144"
/inference="protein motif:PROSITE:PS00103"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43767.1"
/translation="MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFA
NGEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPY
ARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLT
GYIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVV
GDVAGRTCVLIDDMIDTGGTIAGAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGA
REVIVTNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTGLFDGDA"
gene complement(1136573..1138060)
/gene="glmU"
/locus_tag="Rv1018c"
CDS complement(1136573..1138060)
/codon_start=1
/transl_table=11
/gene="glmU"
/locus_tag="Rv1018c"
/product="Probable UDP-N-acetylglucosamine
pyrophosphorylase GlmU"
/note="Rv1018c, (MTCY10G2.31), len: 495 aa. Probable
glmU,UDP-n-acetylglucosamine pyrophosphorylase, similar to
GCAD_BACSU|P14192 UDP-n-acetylglucosamine
pyrophosphorylase (456 aa), FASTA scores: opt: 1150, E():
0, (40.0% identity in 453 aa overlap). Similar to various
Mycobacterium tuberculosis sugar-phosphate transferases
e.g. Rv0334,Rv1213, Rv3264c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1018c"
/db_xref="EnsemblGenomes-Tr:CCP43768"
/db_xref="GOA:P9WMN3"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR005882"
/db_xref="InterPro:IPR011004"
/db_xref="InterPro:IPR025877"
/db_xref="InterPro:IPR029044"
/db_xref="InterPro:IPR038009"
/db_xref="PDB:2QKX"
/db_xref="PDB:3D8V"
/db_xref="PDB:3D98"
/db_xref="PDB:3DJ4"
/db_xref="PDB:3FOQ"
/db_xref="PDB:3SPT"
/db_xref="PDB:3ST8"
/db_xref="PDB:4G3P"
/db_xref="PDB:4G3Q"
/db_xref="PDB:4G3S"
/db_xref="PDB:4G87"
/db_xref="PDB:4HCQ"
/db_xref="UniProtKB/Swiss-Prot:P9WMN3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43768.1"
/translation="MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAI
AKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPD
DYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHE
VMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILR
SDGQTVHASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDV
DVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDG
AAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGAS
SVFVNYDGTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVS
AGPQRNIENWVQRKRPGSPAAQASKRASEMACQQPTQPPDADQTP"
gene complement(1138076..1138147)
/gene="glnT"
tRNA complement(1138076..1138147)
/gene="glnT"
/product="tRNA-Gln"
/anticodon=(pos:complement(1138112..1138114),aa:Gln,
seq:ttg)
/note="codon recognized: CAA; glnT, tRNA-Gln, anticodon
ttg, length = 72"
gene 1138315..1138908
/locus_tag="Rv1019"
CDS 1138315..1138908
/codon_start=1
/transl_table=11
/locus_tag="Rv1019"
/product="Probable transcriptional regulatory protein
(probably TetR-family)"
/note="Rv1019, (MTCY10G2.30c), len: 197 aa. Probable
transcriptional regulator, similar to many memebers of the
TetR family e.g. MTCY7D11.18c (34.4% identity in 189 aa
overlap). Helix turn helix motif from aa 27-48 (+5.42
SD)."
/db_xref="EnsemblGenomes-Gn:Rv1019"
/db_xref="EnsemblGenomes-Tr:CCP43769"
/db_xref="GOA:P96381"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:P96381"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43769.1"
/translation="MTGTERRHQLIGIARSLFAERGYDGTSIEEIAQRANVSKPVVYE
HFGGKEGLYAVVVDREMSALLDGITSSLTNNRSRVRVERVALALLTYVEERTDGFRIM
IRDSPASISSGTYSSLLNDAVSQVSSILAGDFARRGLDPDLAPLYAQALVGSVSMTAQ
WWLDAREPKKEVVAAHLVNLVWNGLTHLEADPRLQDE"
gene 1138967..1142671
/gene="mfd"
/gene_synonym="trcF"
/locus_tag="Rv1020"
CDS 1138967..1142671
/codon_start=1
/transl_table=11
/gene="mfd"
/gene_synonym="trcF"
/locus_tag="Rv1020"
/product="Probable transcription-repair coupling factor
Mfd (TRCF)"
/note="Rv1020, (MTCY10G2.29c), len: 1234 aa. Probable mfd
(alternate gene name: trcF), transcription-repair coupling
factor (see citation below), similar to many e.g.
MFD_ECOLI|P30958 transcription-repair coupling factor from
Escherichia coli (1148 aa), FASTA scores: opt: 1900, E():
0, (37.9% identity in 1107 aa overlap); similar to M.
tuberculosis Rv2973c and Rv1633. Contains PS00017
ATP/GTP-binding site motif A (P-loop). In the N-terminal
section; belongs to the UVRB family. In the C-terminal
section; belongs to the helicase family. RECG subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1020"
/db_xref="EnsemblGenomes-Tr:CCP43770"
/db_xref="GOA:P9WMQ5"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR003711"
/db_xref="InterPro:IPR004576"
/db_xref="InterPro:IPR005118"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036101"
/db_xref="InterPro:IPR037235"
/db_xref="InterPro:IPR041471"
/db_xref="UniProtKB/Swiss-Prot:P9WMQ5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43770.1"
/translation="MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIA
PASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDAVALLPSWETLPHERLS
PGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGD
ESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEM
RMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDM
LAKLAEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGR
EFLEASWSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDES
AIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDT
PAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAK
RRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNT
DKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQ
ASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGK
TEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAES
RAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVD
VLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLR
DGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILV
CTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTE
TAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEA
LETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAAS
SDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLT
LPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAG
KPRQHIGITNPSPPGEDGRGRNTTIKERQP"
gene 1142671..1143648
/locus_tag="Rv1021"
CDS 1142671..1143648
/codon_start=1
/transl_table=11
/locus_tag="Rv1021"
/product="Conserved protein"
/note="Rv1021, (MTCY10G2.28c), len: 325 aa. Conserved
protein, similar to YBL1_STRCI|P33653 hypothetical 26.1
kDa protein from Streptomyces cacaoi (242 aa), FASTA
scores: opt: 493, E(): 1.1e-23, (42.9% identity in 238 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1021"
/db_xref="EnsemblGenomes-Tr:CCP43771"
/db_xref="GOA:P96379"
/db_xref="InterPro:IPR004518"
/db_xref="InterPro:IPR011551"
/db_xref="UniProtKB/Swiss-Prot:P96379"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43771.1"
/translation="MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAAR
SAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGP
WESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSP
FTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQP
ALALAQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERA
IAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR"
gene 1143736..1144467
/gene="lpqU"
/locus_tag="Rv1022"
CDS 1143736..1144467
/codon_start=1
/transl_table=11
/gene="lpqU"
/locus_tag="Rv1022"
/product="Probable conserved lipoprotein LpqU"
/note="Rv1022, (MTCY10G2.27c), len: 243 aa. Probable lpqU
conserved lipoprotein. Similar to Mycobacterium
tuberculosis hypothetical protein Rv1230c|MTV006.02C,
FASTA scores: E(): 2.8e-18, (37.9% identity in 240 aa
overlap). Similar to AL133423|SC4A7.37 hypothetical
protein from Streptomyces coelicolor (421 aa), FASTA
scores: opt: 474,E(): 2.7e-21, (42.2% identity in 211 aa
overlap). Contains PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1022"
/db_xref="EnsemblGenomes-Tr:CCP43772"
/db_xref="GOA:P96378"
/db_xref="InterPro:IPR023346"
/db_xref="InterPro:IPR031304"
/db_xref="UniProtKB/TrEMBL:P96378"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43772.1"
/translation="MSPRRWLRAVAVIGATAMLLASSCTWQLSLFITDGVPPPPGDPV
PPVDTHAGGRPADQLREWAEKRAAALGIPVIALEAYAYAARVAEVENPKCHLAWTTLA
GIGRVESHHGTYRGATIAPNGDVSPPIRGVRLDGTGGTLRIVDRDGGGLDGDAAVERA
MGPMQFISETWRLYGVAARNDGIANVDNIDDAALSAAGYLCWRGKDLATPRGWITALR
AYNNSVIYARAVRDWATAYAAGHPL"
gene 1144564..1145853
/gene="eno"
/locus_tag="Rv1023"
CDS 1144564..1145853
/codon_start=1
/transl_table=11
/gene="eno"
/locus_tag="Rv1023"
/product="Probable enolase Eno"
/note="Rv1023, (MTCY10G2.26c), len: 429 aa. Probable
eno,enolase, highly similar to others e.g.
ENO_ECOLI|P08324 enolase from Escherichia coli (431 aa),
FASTA scores: opt: 1487, E(): 0, (55.5% identity in 422 aa
overlap); etc. Magnesium is required for catalysis and for
stabilizing the dimer. Belongs to the enolase family."
/db_xref="EnsemblGenomes-Gn:Rv1023"
/db_xref="EnsemblGenomes-Tr:CCP43773"
/db_xref="GOA:P9WNL1"
/db_xref="InterPro:IPR000941"
/db_xref="InterPro:IPR020809"
/db_xref="InterPro:IPR020810"
/db_xref="InterPro:IPR020811"
/db_xref="InterPro:IPR029017"
/db_xref="InterPro:IPR036849"
/db_xref="UniProtKB/Swiss-Prot:P9WNL1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43773.1"
/translation="MPIIEQVRAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTG
EHEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDK
SRLGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVD
IQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAAL
DLISRAIESAGLRPGADVALALDAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGA
YPLVSIEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERLEEGIERGVANALLV
KVNQIGTLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPAR
SERVAKYNQLLRIEEALGDAARYAGDLAFPRFACETK"
gene 1145858..1146544
/locus_tag="Rv1024"
CDS 1145858..1146544
/codon_start=1
/transl_table=11
/locus_tag="Rv1024"
/product="Possible conserved membrane protein"
/note="Rv1024, (MTCY10G2.25c), len: 228 aa. Possible
conserved membrane protein, with a hydrophobic region from
aa 83-101. Equivalent to ML0256|NP_301311.1|NC_002677
possible conserved membrane protein from Mycobacterium
leprae (227 aa), S&W scores: 178, E()= 2e-72, Identities:
145/203 (71%). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1024"
/db_xref="EnsemblGenomes-Tr:CCP43774"
/db_xref="InterPro:IPR007060"
/db_xref="UniProtKB/TrEMBL:P96376"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43774.1"
/translation="MPEAKRPESKRRSPASRPGKAGDSVRGGRATKPSAKPSTPAPHA
SRKTTRTPHEHIVEPIKRAITESVEKRSEQRLGFTARRAAILAAVVCVLTLTIARPVR
TYFAQRAEMEQLAATEAMLRRQIADLEEQQVKLADPAYIAAQARERLGFVMPGDIPFQ
VQLPSTPLAPPQPGSDAATATNNEPWYTALWHTIADDPHLPPAAPPAPEPGRPGPLPP
ASPNPEQPGG"
gene 1146561..1147028
/locus_tag="Rv1025"
CDS 1146561..1147028
/codon_start=1
/transl_table=11
/locus_tag="Rv1025"
/product="Conserved protein"
/note="Rv1025, (MTCY10G2.24c), len: 155 aa. Conserved
protein, similar to hypothetical protein
AE001768|AE001768_4 Thermotoga maritima (170 aa) FASTA
scores: opt: 254, E(): 9.5e-10, (35.7% identity in 143 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1025"
/db_xref="EnsemblGenomes-Tr:CCP43775"
/db_xref="InterPro:IPR007511"
/db_xref="UniProtKB/TrEMBL:P96375"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43775.1"
/translation="MVTRQLGRAPRGVLAIAYRCPNGEPGVVKTAPRLPDGTPFPTLY
YLTHPVLTAAASRLETTGLMREMNRRLGQDAELAAAYRRAHESYLSERDALEPLGTTV
SAGGMPDRVKCLHVLIAHSLAKGPGLNPFGDEALALLAAEPRTAATLVAGQWR"
gene 1147019..1147978
/locus_tag="Rv1026"
CDS 1147019..1147978
/codon_start=1
/transl_table=11
/locus_tag="Rv1026"
/product="Conserved protein"
/note="Rv1026, (MTCY10G2.23c), len: 319 aa. Conserved
protein. Similar to GPPA_ECOLI|P25552
guanosine-5'-triphosphate,3'-diphosphate pyrophoshatase
from Escherichia coli (494 aa), FASTA scores: opt:
281,E(): 3.2e-11, (30.6% identity in 291 aa overlap).
Equivalent to AL023514|MLCB4.02 hypothetical protein from
Mycobacterium leprae (317 aa) (77.9% identity in 321 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1026"
/db_xref="EnsemblGenomes-Tr:CCP43776"
/db_xref="GOA:P96374"
/db_xref="InterPro:IPR003695"
/db_xref="UniProtKB/Swiss-Prot:P96374"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43776.1"
/translation="MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRL
GQGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMT
ADVLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHE
VVASYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGL
AGTMTTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRA
DVIGGGAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG"
gene complement(1148427..1149107)
/gene="kdpE"
/locus_tag="Rv1027c"
CDS complement(1148427..1149107)
/codon_start=1
/transl_table=11
/gene="kdpE"
/locus_tag="Rv1027c"
/product="Probable transcriptional regulatory protein
KdpE"
/note="Rv1027c, (MTCY10G2.22), len: 226 aa. Probable
KdpE,transcriptional regulatory protein, similar to others
e.g. KDPE_ECOLI|P21866 kdp operon transcriptional
regulatory protein from Escherichia coli strain K12 (225
aa), FASTA scores: opt: 691, E(): 0, (47.8% identity in
224 aa overlap); AL021530|SC2E9.13 from Streptomyces
coelicolor (227 aa), FASTA scores: opt: 981, E(): 0,
(66.4% identity in 226 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1027c"
/db_xref="EnsemblGenomes-Tr:CCP43777"
/db_xref="GOA:P9WGN1"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="UniProtKB/Swiss-Prot:P9WGN1"
/protein_id="CCP43777.1"
/translation="MTLVLVIDDEPQILRALRINLTVRGYQVITASTGAGALRAAAEH
PPDVVILDLGLPDMSGIDVLGGLRGWLTAPVIVLSARTDSSDKVQALDAGADDYVTKP
FGMDEFLARLRAAVRRNTAAAELEQPVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGM
LEMLARNRGKLVGRGELLKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTES
GMGYRFEA"
gene complement(1149104..1151686)
/gene="kdpD"
/locus_tag="Rv1028c"
CDS complement(1149104..1151686)
/codon_start=1
/transl_table=11
/gene="kdpD"
/locus_tag="Rv1028c"
/product="Probable sensor protein KdpD"
/note="Rv1028c, (MTCY10G2.21), len: 860 aa. Probable
kdpD,sensor protein, similar to others e.g.
KDPD_ECOLI|P21865 sensor protein from Escherichia coli
strain K12 (894 aa),FASTA scores: opt: 1041, E(): 0,
(32.3% identity in 888 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to
universal stress protein family."
/db_xref="EnsemblGenomes-Gn:Rv1028c"
/db_xref="EnsemblGenomes-Tr:CCP43778"
/db_xref="GOA:P9WGL3"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR003852"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR006016"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR025201"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="InterPro:IPR038318"
/db_xref="UniProtKB/Swiss-Prot:P9WGL3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43778.1"
/translation="MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYA
MLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIEMIPPRYVEYRGARFPELDVEAV
LRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQ
ITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGN
LTALREIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGGPESETLVRRASR
IASKSSAELMVVHVIRGDGLAGVSAPQLGRVRELATSLGATMHTVVGDDVPTALLDFA
REMNATQLVVGTSRRSRWARLFDEGIGARTVQEPGGIDVHMVTHPAASRASGWSRVSP
RERHIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALS
ALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRAS
QEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVACVGTNPC
RDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAE
AIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESID
QLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDRVKVD
VGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVNAGRVRERVLINVIDEGPGVPRG
TEEQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAP
EDRP"
gene 1151920..1152012
/gene="kdpF"
/locus_tag="Rv1028A"
CDS 1151920..1152012
/codon_start=1
/transl_table=11
/gene="kdpF"
/locus_tag="Rv1028A"
/product="Probable membrane protein KdpF"
/note="Rv1028A, len: 30 aa. Probable kdpF, membrane
protein, showing similarity with P36937|KDPF_ECOLI|B0698.1
protein KDPF from Escherichia coli strain K12 (see
citation below) (27% identity); and KdpF protein from
Streptomyces coelicolor (51% identity)."
/db_xref="EnsemblGenomes-Gn:Rv1028A"
/db_xref="EnsemblGenomes-Tr:CCP43779"
/db_xref="GOA:Q79FT7"
/db_xref="InterPro:IPR011726"
/db_xref="UniProtKB/TrEMBL:Q79FT7"
/protein_id="CCP43779.1"
/translation="MTTVDNIVGLVIAVALMAFLFAALLFPEKF"
gene 1152012..1153727
/gene="kdpA"
/locus_tag="Rv1029"
CDS 1152012..1153727
/codon_start=1
/transl_table=11
/gene="kdpA"
/locus_tag="Rv1029"
/product="Probable potassium-transporting ATPase a chain
KdpA (potassium-translocating ATPase a chain) (ATP
phosphohydrolase [potassium-transporting] a chain)
(potassium binding and translocating subunit A)"
/note="Rv1029, (MTCY10G2.20c), len: 571 aa. Probable
kdpA,potassium-transporting ATPase a chain (transmembrane
protein), similar to others e.g.
ATKA_ECOLI|P03959|KDPA|B0698 potassium-transporting ATPase
A chain from Escherichia coli strain K12 (557 aa), FASTA
scores: opt: 1763, E(): 0, (50.4% identity in 569 aa
overlap); etc. Belongs to the KdpA family."
/db_xref="EnsemblGenomes-Gn:Rv1029"
/db_xref="EnsemblGenomes-Tr:CCP43780"
/db_xref="GOA:P9WKF3"
/db_xref="InterPro:IPR004623"
/db_xref="UniProtKB/Swiss-Prot:P9WKF3"
/protein_id="CCP43780.1"
/translation="MSGTSWLQFAALIAVLLLTAPALGGYLAKIYGDEAKKPGDRVFG
PIERVIYQVCRVDPGSEQRWSTYALSVLAFSVMSFLLLYGIARFQGVLPFNPTDKPAV
TDHVAFNAAVSFMTNTNWQSYSGEATMSHFTQMTGLAVQNFVSASAGMCVLAALIRGL
ARKRASTLGNFWVDLARTVLRIMFPLSFVVAILLVSQGVIQNLHGFIVANTLEGAPQL
IPGGPVASQVAIKQLGTNGGGFFNVNSAHPFENYTPIGNFVENWAILIIPFALCFAFG
KMVHDRRQGWAVLAIMGIIWIGMSVAAMSFEAKGNPRLDALGVTQQTTVDQSGGNLEG
KEVRFGVGASGLWAASTTGTSNGSVNSMHDSYTPLGGMVPLAHMMLGEVSPGGTGVGL
NGLLVMAILAVFIAGLMVGRTPEYLGKKIQATEMKLVTLYILAMPIALLSFAAASVLI
SSALASRNNPGPHGLSEILYAYTSGANNNGSAFAGLTASTWSYDTTIGVAMLIGRFFL
IIPVLAIAGSLARKGTTPVTAATFPTHKPLFVGLVIGVVLIVGGLTFFPALALGPIVE
QLSTQ"
gene 1153724..1155853
/gene="kdpB"
/locus_tag="Rv1030"
CDS 1153724..1155853
/codon_start=1
/transl_table=11
/gene="kdpB"
/locus_tag="Rv1030"
/product="Probable potassium-transporting P-type ATPase B
chain KdpB (potassium-translocating ATPase B chain) (ATP
phosphohydrolase [potassium-transporting] B chain)
(potassium binding and translocating subunit B)"
/note="Rv1030, (MTCY10G2.19c), len: 709 aa. Probable
kdpB,potassium-transporting P-type ATPase B chain
(transmembrane protein), similar to others e.g.
ATKB_ECOLI|P03960 potassium-transporting ATPase B chain
from Escherichia coli strain K12 (682 aa), FASTA scores:
opt: 1481, E(): 0,(63.4% identity in 686 aa overlap); etc.
Very similar to AL078610|SCH35.47 H+/K+-exchanging ATPase
chain B from Streptomyces coelicolor (707 aa), FASTA
scores: opt: 2731,E(): 0, (71.6% identity in 676 aa
overlap). Contains PS00154 E1-E2 ATPases phosphorylation
site."
/db_xref="EnsemblGenomes-Gn:Rv1030"
/db_xref="EnsemblGenomes-Tr:CCP43781"
/db_xref="GOA:P9WPU3"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR006391"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPU3"
/inference="protein motif:PROSITE:PS00154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43781.1"
/translation="MMIARMETSATAAAATSAPRLRLAKRSLFDPMIVRSALPQSLRK
LAPRVQARNPVMLVVLVGAVITTLAFLRDLASSTAQENVFNGLVAAFLWFTVLFANFA
EAMAEGRGKAQAAALRKVRSETMANRRTAAGNIESVPSSRLDLDDVVEVSAGETIPSD
GEIIEGIASVDESAITGESAPVIRESGGDRSAVTGGTVVLSDRIVVRITAKQGQTFID
RMIALVEGAARQQTPNEIALNILLAGLTIIFLLAVVTLQPFAIYSGGGQRVVVLVALL
VCLIPTTIGALLSAIGIAGMDRLVQHNVLATSGRAVEAAGDVNTLLLDKTGTITLGNR
QATEFVPINGVSAEAVADAAQLSSLADETPEGRSIVVLAKDEFGLRARDEGVMSHARF
VPFTAETRMSGVDLAEVSGIRRIRKGAAAAVMKWVRDHGGHPTEEVGAIVDGISSGGG
TPLVVAEWTDNSSARAIGVVHLKDIVKVGIRERFDEMRRMSIRTVMITGDNPATAKAI
AQEAGVDDFLAEATPEDKLALIKREQQGGRLVAMTGDGTNDAPALAQADVGVAMNTGT
QAAREAGNMVDLDSDPTKLIEVVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFVG
LYPVLDKLNVMALHSPRSAILSAVIFNALVIVALIPLALRGVRFRAESASAMLRRNLL
IYGLGGLVVPFIGIKLVDLVIVALGVS"
gene 1155853..1156422
/gene="kdpC"
/locus_tag="Rv1031"
CDS 1155853..1156422
/codon_start=1
/transl_table=11
/gene="kdpC"
/locus_tag="Rv1031"
/product="Probable potassium-transporting ATPase C chain
KdpC (potassium-translocating ATPase C chain) (ATP
phosphohydrolase [potassium-transporting] C chain)
(potassium binding and translocating subunit C)"
/note="Rv1031, (MTCY10G2.18c), len: 189 aa. Probable
kdpC,potassium-transporting ATPase C chain (membrane
protein) ,similar to others e.g. ATKC_ECOLI|P03961
potassium-transporting ATPase C chain from Escherichia
coli strain K12 (190 aa), FASTA scores: opt: 475, E():
3.1e-24,(45.7% identity in 186 aa overlap); etc. Belongs
to the KdpC family."
/db_xref="EnsemblGenomes-Gn:Rv1031"
/db_xref="EnsemblGenomes-Tr:CCP43782"
/db_xref="GOA:P9WKF1"
/db_xref="InterPro:IPR003820"
/db_xref="UniProtKB/Swiss-Prot:P9WKF1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43782.1"
/translation="MRRQLLPALTMLLVFTVITGIVYPLAVTGVGQLFFGDQANGALL
ERDGQVIGSAHIGQQFTAAKYFHPRPSSAGDGYDAAASSGSNLGPTNEKLLAAVAERV
TAYRKENNLPADTLVPVDAVTGSGSGLDPAISVVNAKLQAPRVAQARNISIRQVERLI
EDHTDARGLGFLGERAVNVLRLNLALDRL"
gene complement(1156426..1157955)
/gene="trcS"
/locus_tag="Rv1032c"
CDS complement(1156426..1157955)
/codon_start=1
/transl_table=11
/gene="trcS"
/locus_tag="Rv1032c"
/product="Two component sensor histidine kinase TrcS"
/note="Rv1032c, (MTCY10G2.17), len: 509 aa. TrcS, two
component sensor histidine kinase protein (see citations
below), similar to YV16_MYCLE|P54883 probable sensor-like
histidine kinase from Mycobacterium leprae (443 aa), FASTA
scores: opt: 392, E(): 3.8e-18, (31.7% identity in 334 aa
overlap). Note that in vitro autophosphorylation of TrcS
requires the presence of Mn2+ or Ca2+ as a divalent cation
cofactor and subsequent transphosphorylation of TrcR is
evident in the presence of TrcS-phosphate and Ca2+."
/db_xref="EnsemblGenomes-Gn:Rv1032c"
/db_xref="EnsemblGenomes-Tr:CCP43783"
/db_xref="GOA:P96368"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/TrEMBL:P96368"
/protein_id="CCP43783.1"
/translation="MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSV
LSLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGN
LIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSS
AAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAA
TAAEVATMPLTDDDHQISVRVRPGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDL
RMRQFITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDE
LLLLSRLSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARL
HQLVSNLLTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFD
RFVRASKSRSNGSGHGLGLAIVSSIVKAHRGSVTAESGNGQTVFRVRLPMIEQQIATT
A"
gene complement(1157963..1158736)
/gene="trcR"
/locus_tag="Rv1033c"
CDS complement(1157963..1158736)
/codon_start=1
/transl_table=11
/gene="trcR"
/locus_tag="Rv1033c"
/product="Two component transcriptional regulator TrcR"
/note="Rv1033c, (MTCY10G2.16), len: 257 aa.
TrcR,two-component regulatory protein (see citations
below),similar to Q50825 two component response regulator
from Mycobacterium tuberculosis (234 aa), FASTA scores:
opt: 628, E(): 0, (46.0% identity in 226 aa overlap). Note
that in vitro autophosphorylation of TrcS requires the
presence of Mn2+or Ca2+as a divalent cation cofactor and
subsequent transphosphorylation of TrcR is evident in the
presence of TrcS-phosphate and Ca2+."
/db_xref="EnsemblGenomes-Gn:Rv1033c"
/db_xref="EnsemblGenomes-Tr:CCP43784"
/db_xref="GOA:L7N689"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="UniProtKB/TrEMBL:L7N689"
/protein_id="CCP43784.1"
/translation="MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALT
NLVKMALHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRESDV
YTPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRRSSHLERPADEA
LRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNPRRALSRTEILDRVWNYDFA
GRTSIVDLYISYLRKKIDSDREPMIHTVRGIGYMLRPPE"
gene complement(1158918..1159307)
/locus_tag="Rv1034c"
CDS complement(1158918..1159307)
/codon_start=1
/transl_table=11
/locus_tag="Rv1034c"
/product="Probable transposase (fragment)"
/note="Rv1034c, (MTCY10G2.15), len: 129 aa. Probable
IS1560 transposase fragment, similar to part of
Rv3387|E1202305|MTV004.45 (225 aa) (65.1% identity in 129
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1034c"
/db_xref="EnsemblGenomes-Tr:CCP43785"
/db_xref="GOA:I6X043"
/db_xref="InterPro:IPR002559"
/db_xref="UniProtKB/TrEMBL:I6X043"
/protein_id="CCP43785.1"
/translation="MQQGNPPDAPQLAPAVAWVKKRAGRTPRTVTADRGYGEAAVDQQ
LTEVGVKNVLIPRKGKPSQDRRAEEHRKAFRRTIKWRTGCEGRISHLKRGYGWDRGRI
GGLEGTRTWVGHGVFAHNLVTISALPA"
mobile_element complement(1158921..1160433)
/mobile_element_type="insertion sequence:IS1560-1"
/note="IS1560-1, len: 1513 nt. Insertion sequence IS1560."
gene complement(1159375..1160061)
/locus_tag="Rv1035c"
CDS complement(1159375..1160061)
/codon_start=1
/transl_table=11
/locus_tag="Rv1035c"
/product="Probable transposase (fragment)"
/note="Rv1035c, (MTCY10G2.14), len: 228 aa. Probable
IS1560 transposase fragment, similar to parts of
Rv3387|E1202305|MTV004.45 (225 aa) (47.8% identity in 67
aa overlap) and Rv3386|E1202304|MTV004.44 (234 aa) (55.1%
identity in 127 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1035c"
/db_xref="EnsemblGenomes-Tr:CCP43786"
/db_xref="GOA:P96366"
/db_xref="UniProtKB/TrEMBL:P96366"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43786.1"
/translation="MPHPTTLMKLTTRCGSAAIDGLNEALLAKAAEAKLLGTNRIRAD
TTVARANVSYPTDLGLLAKAMRRIAATGKRIQAAGGAVRTRVGDRSRAAGRRAHAVAA
KLRSRAELGRDEARAAVLRFTGELAELAQAAAQEAQQLLDNAKQAVLRAKAKAAALAA
RGERDAVAGRRCGGLVRAVNDLTELLNATRQIVAQTRQRVAGITSDGASRRVSLHDGD
ARPDHQGSAR"
gene complement(1160095..1160433)
/locus_tag="Rv1036c"
CDS complement(1160095..1160433)
/codon_start=1
/transl_table=11
/locus_tag="Rv1036c"
/product="Probable IS1560 transposase (fragment)"
/note="Rv1036c, (MTCY10G2.13), len: 112 aa. Probable
IS1560 transposase fragment, similar to part of
Rv3386|E1202304|MTV004.44 (234 aa) (82.8% identity in 87
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1036c"
/db_xref="EnsemblGenomes-Tr:CCP43787"
/db_xref="UniProtKB/TrEMBL:P96365"
/protein_id="CCP43787.1"
/translation="MIPGRMVLNWEDGLNALVAEGIEAIVFRTLGDQCWLWESLLPDE
VRRLPEELARVDALLDDPAFFAPFVPFFDPRRGRPSTPMEVYLQLMFVKFRYRLGYES
LCREVADSIT"
gene complement(1160544..1160828)
/gene="esxI"
/gene_synonym="ES6_1"
/gene_synonym="Mtb9.9D"
/locus_tag="Rv1037c"
CDS complement(1160544..1160828)
/codon_start=1
/transl_table=11
/gene="esxI"
/gene_synonym="ES6_1"
/gene_synonym="Mtb9.9D"
/locus_tag="Rv1037c"
/product="Putative ESAT-6 like protein EsxI (ESAT-6 like
protein 1)"
/note="Rv1037c, (MTCY10G2.12), len: 94 aa. EsxI, ESAT-6
like protein (see citations below), highly similar to
Q49946|ES6X_MYCLE|U1756D putative ESAT-6 like protein X
from Mycobacterium leprae (95 aa), FASTA scores: opt:
409,E(): 6.3e-23, (64.15% identity in 92 aa overlap);
Rv3619c,Rv1198, Rv2346c, etc from Mycobacterium
tuberculosis. Strictly identical to
P96364|ES61_MYCTU|Rv3619c|MTCY15C10.33|MTCY07H7B.03|MT3721
putative ESAT-6 like protein 1 (94 aa). Belongs to the
ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv1037c"
/db_xref="EnsemblGenomes-Tr:CCP43788"
/db_xref="GOA:P0DOA6"
/db_xref="InterPro:IPR009416"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P0DOA6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43788.1"
/translation="MTINYQFGDVDAHGAMIRAQAGSLEAEHQAIISDVLTASDFWGG
AGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA"
gene complement(1160855..1161151)
/gene="esxJ"
/gene_synonym="ES6_2"
/gene_synonym="QILSS"
/gene_synonym="TB11.0"
/locus_tag="Rv1038c"
CDS complement(1160855..1161151)
/codon_start=1
/transl_table=11
/gene="esxJ"
/gene_synonym="ES6_2"
/gene_synonym="QILSS"
/gene_synonym="TB11.0"
/locus_tag="Rv1038c"
/product="ESAT-6 like protein EsxJ (ESAT-6 like protein
2)"
/note="Rv1038c, (MT1067, MTCY10G2.11), len: 98 aa.
EsxJ,ESAT-6 like protein (see Gey Van Pittius et al.,
2001),similar to Q49945|U1756C, Mycobacterium leprae (100
aa),FASTA scores: opt: 375, E(): 7.7e-21, (58.3% identity
in 96 aa overlap). Member of M. tuberculosis hypothetical
QILSS protein family with Rv1197, Rv1792, Rv2347c and
Rv3620c. Belongs to the ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv1038c"
/db_xref="EnsemblGenomes-Tr:CCP43789"
/db_xref="GOA:P9WNJ9"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNJ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43789.1"
/translation="MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAG
WSGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS"
gene complement(1161297..1162472)
/gene="PPE15"
/locus_tag="Rv1039c"
CDS complement(1161297..1162472)
/codon_start=1
/transl_table=11
/gene="PPE15"
/locus_tag="Rv1039c"
/product="PPE family protein PPE15"
/note="Rv1039c, (MTCY10G2.10), len: 391 aa. PPE15, Member
of the Mycobacterium tuberculosis PPE family of
glycine-rich proteins, most similar to
Rv2768c|AL008967|MTV002_33 Mycobacterium tuberculosis
H37Rv (394 aa), FASTA scores: opt: 1721, E(): 0, (70.4%
identity in 398 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1039c"
/db_xref="EnsemblGenomes-Tr:CCP43790"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="PDB:5XFS"
/db_xref="UniProtKB/Swiss-Prot:P9WI31"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43790.1"
/translation="MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAELGTTAAS
YESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAGSQAMASAAAYEAAYA
MTVPPEVVAANRALLAALVATNVLGINTPAIMATEALYAEMWAQDALAMYGYAAASGA
AGMLQPLSPPSQTTNPGGLAAQSAAVGSAAATAAVNQVSVADLISSLPNAVSGLASPV
TSVLDSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSGA
PVAIAEGAIEAAEGAASAAAAGLADSVTPAGLGASLGEATLVGRLSVPAAWSTAAPAT
TAGATALEGSGWTVAAEEAGPVTGMMPGMASAAKGTGAYAGPRYGFKPTVMPKQVVV"
gene complement(1162549..1163376)
/gene="PE8"
/locus_tag="Rv1040c"
CDS complement(1162549..1163376)
/codon_start=1
/transl_table=11
/gene="PE8"
/locus_tag="Rv1040c"
/product="PE family protein PE8"
/note="Rv1040c, (MTCY10G2.09), len: 275 aa. PE8, Member of
the Mycobacterium tuberculosis PE family (see citation
below), most similar to AL008967|MTV002_34 Mycobacterium
tuberculosis H37Rv (275 aa), FASTA scores: opt: 1111, E():
0, (68.6% identity in 283 aa overlap). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1040c"
/db_xref="EnsemblGenomes-Tr:CCP43791"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR022171"
/db_xref="PDB:5XFS"
/db_xref="UniProtKB/TrEMBL:L7N667"
/protein_id="CCP43791.1"
/translation="MSFLKTVPEELTAAAAQLGTIGAAMAAQNAAAAAPTTAIAPAAL
DEVSALQAALFTAYGTFYQQVSAEAQAMHDMFVNTLGISAGTYGVTESLNSSAAASPL
SGITGEASAIIQATTGLFPPELSGGIGNILNIGAGNWASATSTLIGLAGGGLLPAEEA
AEAASALGGEAALGELGALGAAEAALGEAGIAAGLGSASAIGMLSVPPAWAGQATLVS
TTSTLPGAGWTAAAPQAAAGTFIPGMPGVASAARNSAGFGAPRYGVKPIVMPKPATV"
mobile_element complement(1164572..1165549)
/mobile_element_type="insertion sequence:IS-LIKE-1"
/note="IS-LIKE-1, len: 978 nt. Insertion sequence,
ISLIKE,region identical to cosmid y348, blast score= 4902
(+1) 9377 10354 EM_NEW:MTAD20 Ad000020 Mycobacterium
tuberculosis sequence from clone y348. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
gene complement(1164572..1165435)
/locus_tag="Rv1041c"
CDS complement(1164572..1165435)
/codon_start=1
/transl_table=11
/locus_tag="Rv1041c"
/product="Probable is like-2 transposase"
/note="Rv1041c, (MTCY10G2.08), len: 287 aa. Probable is
like-2 transposase, overlaps MTCY10G2.07. Similar to
Q00430|X53945 insertion element IS869 hypothetical protein
from Agrobacterium tumefaciens (186 aa), FASTA scores:
opt: 173, E(): 0.00016, (40.9% identity in 176 aa
overlap). Similar to Rv1150, C-terminal part of
transposase of putative Mycobacterium tuberculosis is
like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with
respect to Mycobacterium tuberculosis Q50761 transposase,
the 10G2 cosmid sequence appears to be correct. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1041c"
/db_xref="EnsemblGenomes-Tr:CCP43792"
/db_xref="GOA:P96360"
/db_xref="InterPro:IPR002559"
/db_xref="UniProtKB/TrEMBL:P96360"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43792.1"
/translation="MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGS
AITVGRWMVPATRCSPTLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSP
QGALSDYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLP
LLDDYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAK
GSAGGRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHA
RVGTPKLGDTP"
repeat_region 1164572..1164589
/note="18 bp inverted repeat at the left end of IS-LIKE
element, CTAGGGCGTGTCTCCCAA. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene complement(1165092..1165499)
/locus_tag="Rv1042c"
CDS complement(1165092..1165499)
/codon_start=1
/transl_table=11
/locus_tag="Rv1042c"
/product="Probable is like-2 transposase"
/note="Rv1042c, (MTCY10G2.07), len: 135 aa. Probable is
like-2 transposase, similar to Q50761 transposase from
Mycobacterium tuberculosis (308 aa), FASTA scores: opt:
823, E(): 0, (99.1% identity in 117 aa overlap). Second
copy is Rv1149. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1042c"
/db_xref="EnsemblGenomes-Tr:CCP43793"
/db_xref="InterPro:IPR025161"
/db_xref="UniProtKB/TrEMBL:L0T897"
/protein_id="CCP43793.1"
/translation="MTRVGVISDEFWAVVEPLMPSHEGKPGRRFSDHRLILEGIAWRF
RTGSPWRDLPAEFGPWQTVWKRHHRWSLDGTCDEVFAHVAAVFGVDAEVAEDIEKLLS
VDSTNVRAHQHSAGACSDTLATGGTVGLQEIRR"
repeat_region complement(1165532..1165549)
/note="18 bp inverted repeat at the right end of a IS-LIKE
element, CTAGGGCGTGTCTCCCAA. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene complement(1165781..1166806)
/locus_tag="Rv1043c"
CDS complement(1165781..1166806)
/codon_start=1
/transl_table=11
/locus_tag="Rv1043c"
/product="Conserved hypothetical protein"
/note="Rv1043c, (MTCY10G2.06), len: 341 aa. Conserved
hypothetical protein similar to AL096872|SC5F7.08 putative
lipoate-protein ligase from Streptomyces coelicolor (362
aa), FASTA scores: opt: 206, E(): 1.4e-05, (30.3% identity
in 201 aa overlap). Weak similarity to P39668|YYXA_BACSU
hypothetical protease from Bacillus subtitis (400
aa),FASTA scores: opt: 159, E(): 0.013, (27.1% identity in
210 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv1043c"
/db_xref="EnsemblGenomes-Tr:CCP43794"
/db_xref="InterPro:IPR009003"
/db_xref="UniProtKB/TrEMBL:P96358"
/protein_id="CCP43794.1"
/translation="MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSV
ADFSRYLSTLGLPAAGDAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGAISK
GQRGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKH
VVTGLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGG
MAFRDPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARP
GNSGGPIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGI
VEMDTLP"
gene 1167053..1167676
/locus_tag="Rv1044"
CDS 1167053..1167676
/codon_start=1
/transl_table=11
/locus_tag="Rv1044"
/product="Conserved hypothetical protein"
/note="Rv1044, (MTCY10G2.05c), len: 207 aa. Conserved
hypothetical protein, similar to Mycobacterium
tuberculosis hypothetical protein MTCY06G11.02C|P96837
(289 aa), fasta scores: E(): 8.9e-06, (30.7% identity in
150 aa overlap). Some similarity to U36837|LLU36837_1
Lactococcus lactis plasmid pNP40 (287 aa), FASTA scores:
opt: 147, E (): 0.0087, (29.7% identity in 91 aa overlap).
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1044"
/db_xref="EnsemblGenomes-Tr:CCP43795"
/db_xref="InterPro:IPR025159"
/db_xref="UniProtKB/TrEMBL:P96357"
/protein_id="CCP43795.1"
/translation="MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPV
QLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAVSWTLGRGVISHESALALHALAD
VNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA"
gene 1167673..1168554
/locus_tag="Rv1045"
CDS 1167673..1168554
/codon_start=1
/transl_table=11
/locus_tag="Rv1045"
/product="Hypothetical protein"
/note="Rv1045, (MTCY10G2.04c), len: 293 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1045"
/db_xref="EnsemblGenomes-Tr:CCP43796"
/db_xref="InterPro:IPR014942"
/db_xref="UniProtKB/TrEMBL:P96356"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43796.1"
/translation="MTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQ
FAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKDFDTVARRDIELIHEQLADAGET
GWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGL
LLDADLMPTRSACIAIFEARAQHPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAA
AQAVQRFVARIDRATKR"
gene complement(1168704..1169228)
/locus_tag="Rv1046c"
CDS complement(1168704..1169228)
/codon_start=1
/transl_table=11
/locus_tag="Rv1046c"
/product="Hypothetical protein"
/note="Rv1046c, (MTCY10G2.03), len: 174 aa. Hypothetical
unknown protein. Start changed since first submission (-65
aa). This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1046c"
/db_xref="EnsemblGenomes-Tr:CCP43797"
/db_xref="UniProtKB/TrEMBL:L0T8G6"
/protein_id="CCP43797.1"
/translation="MKVQARVGWNRRQLSAVGGRGQQLFANAPGHIPSTSHRRGTGDI
NRKIDESLAGAARPQANANYGATSDPPLTHQPKPGSPTQVGPRSPSPPGLRGLVKQLP
EVHQSSLHLDTVASLPSSRPSPHHTPLALRSRSGHFSPDEIRNRRSRKRSQSHMPPRT
PPRGRCLRAPEALA"
mobile_element 1169298..1170732
/mobile_element_type="insertion sequence:IS1081-1"
/note="IS1081-1, len: 1435 nt. Insertion sequence
IS1081,almost identical to Mycobacterium bovis IS1081
(7157 (-1) 60 14 94 EM_BA:MBBIS1081 X84741 Mycobacterium
bovis BCG IS1081 DNA. 4/96. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 1169423..1170670
/locus_tag="Rv1047"
CDS 1169423..1170670
/codon_start=1
/transl_table=11
/locus_tag="Rv1047"
/product="Probable transposase"
/note="Rv1047, (MTCY10G2.02c), len: 415 aa. IS1081
transposase, most similar to TRA1_MYCBO|P35882 transposase
for insertion sequence element (415 aa), FASTA scores:
opt: 2675, E(): 0, (99.8% identity in 415 aa overlap).
Contains PS01007 Transposases, Mutator family, signature.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1047"
/db_xref="EnsemblGenomes-Tr:CCP43798"
/db_xref="GOA:P96354"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/TrEMBL:P96354"
/inference="protein motif:PROSITE:PS01007"
/protein_id="CCP43798.1"
/translation="MTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADAL
CGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERA
LTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGP
YTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRD
LVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRT
LLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIW
SNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRA
RAALTSTEEPAKQQTTNTPALTT"
gene complement(1171038..1172153)
/locus_tag="Rv1048c"
CDS complement(1171038..1172153)
/codon_start=1
/transl_table=11
/locus_tag="Rv1048c"
/product="Hypothetical protein"
/note="Rv1048c, (MTV017.01c-MTCY10G2.01), len: 371 aa.
Hypothetical unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1048c"
/db_xref="EnsemblGenomes-Tr:CCP43799"
/db_xref="UniProtKB/TrEMBL:P96353"
/protein_id="CCP43799.1"
/translation="MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSAL
EGAFRSEVRARRVNGPHRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAP
TMSPGARKAAHDAGVGWVDESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRA
TLAVCEALLANIAGPTVASVVEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLI
VDRDALLDAYAEAADKLRSPISISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSA
SLLAPMQTEIAPMEIYVPGRSWSDLRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQ
NLQGFRSMLWPRVYADLRTAGVRGEDAAEHLREAMTK"
gene 1172386..1172832
/locus_tag="Rv1049"
CDS 1172386..1172832
/codon_start=1
/transl_table=11
/locus_tag="Rv1049"
/product="Probable transcriptional repressor protein"
/note="Rv1049, (MTV017.02), len: 148 aa. Probable
transcriptional repressor protein, similar to many e.g.
P74870 negative regulator of EMR locus EMR from Salmonella
typhimurium (149 aa), FASTA scores: opt: 146, E():
0.0011,(31.6% identity in 95 aa overlap). Contains
probable helix-turn-helix motif at aa 58-79 (Score 1495,
+4.28 SD). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1049"
/db_xref="EnsemblGenomes-Tr:CCP43800"
/db_xref="GOA:I6Y5H3"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:I6Y5H3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43800.1"
/translation="MGKGAAFDECACYTTRRAARQLGQAYDRALRPSGLTNTQFSTLA
VISLSEGSAGIDLTMSELAARIGVERTTLTRNLEVMRRDGLVRVMAGADARCKRIELT
AKGRAALQKAVPLWRGVQAEVTASVGDWPRVRRDIANLGQAAEACR"
gene 1172881..1173786
/locus_tag="Rv1050"
CDS 1172881..1173786
/codon_start=1
/transl_table=11
/locus_tag="Rv1050"
/product="Probable oxidoreductase"
/note="Rv1050, (MTV017.03), len: 301 aa. Probable
oxidoreductase similar to many e.g.
Rv1543|MTCY48.22C|Q10783 putative oxidoreductase CY48.22C
(341 aa), FASTA scores: opt: 462, E(): 3e-22, (33.6%
identity in 265 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1050"
/db_xref="EnsemblGenomes-Tr:CCP43801"
/db_xref="GOA:O53398"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53398"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43801.1"
/translation="MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGA
LRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGPVD
AETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRKAFARFAGYSS
AMHAIAGFSDALRQELRGSGIAVSVIHPALTQTPLLANVDPADMPPPFRSLTPIPVHW
VAAAVLDGVARRRARVVVPFQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGS
VYRHQPTESAKAQAAQPERGYSSAR"
gene complement(1173945..1174700)
/locus_tag="Rv1051c"
CDS complement(1173945..1174700)
/codon_start=1
/transl_table=11
/locus_tag="Rv1051c"
/product="Conserved hypothetical protein"
/note="Rv1051c, (MTV017.04c), len: 251 aa. Conserved
hypothetical protein, similar to LLU36837|U36837.1 protein
encoded by Lactococcus lactis plasmid pNP40 (298 aa),
FASTA scores: opt: 194, E(): 3.5e-06, (30.3% identity in
155 aa overlap). Contains possible helix-turn-helix motif
at aa 197-218 (Score 1097, +2.92 SD). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1051c"
/db_xref="EnsemblGenomes-Tr:CCP43802"
/db_xref="GOA:O53399"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR014942"
/db_xref="InterPro:IPR041657"
/db_xref="UniProtKB/TrEMBL:O53399"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43802.1"
/translation="MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADY
PGLRVRVAMSVGPWQGIAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAE
KGVTILERGITSTRWRDYVDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAG
YGAVAQAKWATEHGRCQHCWRHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHS
DIGPASFTLGRRVVYRRDEVSRWISKRESATRR"
gene 1175225..1175315
/gene="mpr5"
ncRNA 1175225..1175315
/gene="mpr5"
/product="Fragment of putative small regulatory RNA"
/note="mpr5, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), ends not mapped, ~100 nt band
detected by Northern blot."
/ncRNA_class="other"
gene 1175723..1176112
/locus_tag="Rv1052"
CDS 1175723..1176112
/codon_start=1
/transl_table=11
/locus_tag="Rv1052"
/product="Hypothetical protein"
/note="Rv1052, (MTV017.05), len: 129 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1052"
/db_xref="EnsemblGenomes-Tr:CCP43803"
/db_xref="UniProtKB/TrEMBL:O53400"
/protein_id="CCP43803.1"
/translation="MDCCEERGVARHKGLSQVGTPGCPRWSQAVSCRCSAYREAAVTA
VQMPLTPGYGETPLPHDELAALLPEVVEVLDKPITRADVYDLEQGLQDQVFDLLMPTA
VEGSLSLDELLSDHFVRDLHARMFGPV"
gene complement(1176011..1176286)
/locus_tag="Rv1053c"
CDS complement(1176011..1176286)
/codon_start=1
/transl_table=11
/locus_tag="Rv1053c"
/product="Hypothetical protein"
/note="Rv1053c, (MTV017.06c), len: 91 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1053c"
/db_xref="EnsemblGenomes-Tr:CCP43804"
/db_xref="UniProtKB/TrEMBL:O53401"
/protein_id="CCP43804.1"
/translation="MDSHKVCMNNNTQLPTGPIIGVHPAVRDGVERVAYLDGDLLRCN
TDVEFTSSPPPGPVLYRTKHTRVEIADEMVTEKLIKRQRAFNSRRHQ"
gene 1176928..1177242
/locus_tag="Rv1054"
CDS 1176928..1177242
/codon_start=1
/transl_table=11
/locus_tag="Rv1054"
/product="Probable integrase (fragment)"
/note="Rv1054, (MTV017.07), len: 104 aa. Probable
integrase (fragment), similar to
Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows
similarity to integrases) from Mycobacterium tuberculosis
(151 aa), FASTA scores: opt: 273, E(): 8.8e-13, (64.7%
identity in 68 aa overlap); and to L39071|MSGINT_1
integrase from Mycobacterium paratuberculosis (191 aa),
FASTA scores: opt: 105, E(): 0.9, (31.8% identity in 85
aaoverlap). This ORF continues in another frame as
Rv1055|MTV017.08 but no error can be found to account for
frameshift. Length extended since first submission (+36
aa). This region is a possible MT-complex-specific genomic
island (See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1054"
/db_xref="EnsemblGenomes-Tr:CCP43805"
/db_xref="GOA:O53402"
/db_xref="InterPro:IPR011010"
/db_xref="InterPro:IPR014417"
/db_xref="UniProtKB/TrEMBL:O53402"
/protein_id="CCP43805.1"
/translation="MTGKGIVESTTKTKRDRHVPVPEPVWRRLHAELPTDPNALVFPG
RKGGFLPLGEYRWAFDNAGDQVGIEGWYRTVWGTPRPRWRSAQALTSRSCNGSLDTQQ
RR"
gene 1177239..1177373
/locus_tag="Rv1055"
CDS 1177239..1177373
/codon_start=1
/transl_table=11
/locus_tag="Rv1055"
/product="Possible integrase (fragment)"
/note="Rv1055, (MTV017.08), len: 44 aa. Possible integrase
(fragment); first 49 aa similar to
Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows
similarity to integrases) from Mycobacterium tuberculosis
(151 aa), FASTA scores: opt: 291, E(): 2.2e-16, (74.3%
identity in 70 aa overlap); and to L39071|MSGINT_1
integrase from Mycobacterium paratuberculosis (191
aa),FASTA scores: opt: 146, E(): 8.3e-05, (52.1% identity
in 48 aa overlap); and to many other integrases or
transposases. Shortened since first submission (-34 aa).
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1055"
/db_xref="EnsemblGenomes-Tr:CCP43806"
/db_xref="UniProtKB/TrEMBL:O53403"
/protein_id="CCP43806.1"
/translation="MTLDRHGHLLNDDLAVWPMRCAKSSRTLRYHCGMRRRNRVGLRA
"
gene 1177396..1177469
/gene="leuX"
tRNA 1177396..1177469
/gene="leuX"
/product="tRNA-Leu"
/anticodon=(pos:1177430..1177432,aa:Leu,seq:taa)
/note="codon recognized: UUA; leuX, tRNA-Leu, anticodon
taa, length = 74. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene 1177628..1178392
/locus_tag="Rv1056"
CDS 1177628..1178392
/codon_start=1
/transl_table=11
/locus_tag="Rv1056"
/product="Conserved protein"
/note="Rv1056, (MTV017.09), len: 254 aa. Conserved
protein,some similarity in C-terminal region of
Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126
aa),FASTA scores: opt: 254, E(): 1.2e-10, (43.4% identity
in 106 aa overlap); and to Rv1670. C-terminal region is
similar to AL035569|SC8D9.02 hypothetical protein from
Streptomyces coelicolor (113 aa), FASTA scores: opt:
282,E(): 4.5e-12, (48.0% identity in 100 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1056"
/db_xref="EnsemblGenomes-Tr:CCP43807"
/db_xref="GOA:O53404"
/db_xref="InterPro:IPR007361"
/db_xref="InterPro:IPR038694"
/db_xref="UniProtKB/TrEMBL:O53404"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43807.1"
/translation="MSVDYPQMAATRGRIEPAPRRVRGYLGHVLVFDTSAARYVWEVP
YYPQYYIPLADVRMEFLRDENHPQRVQLGPSRLHSLVSAGQTHRSAARVFDVDGDSPV
AGTVRFNWDPLRWFEEDEPIYGHPRNPYQRADALRSHRHVRVELDGIVLADTRSPVLL
FETGIPTRYYIDPADIAFEHLEPTSTQTLCPYKGTTSGYWSVRVGDAVHRDLAWTYHY
PLPAVAPIAGLVAFYNEKVDLTVDGVALPRPHTQFS"
repeat_region 1179345..1179395
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 1179396..1180577
/locus_tag="Rv1057"
CDS 1179396..1180577
/codon_start=1
/transl_table=11
/locus_tag="Rv1057"
/product="Conserved hypothetical protein"
/note="Rv1057, (MTV017.10), len: 393 aa. Conserved
hypothetical protein, some similarity to X84710|MMSAG_1
surface antigen of Methanosarcina mazeii (491 aa), FASTA
scores: opt: 363, E():6.2e-15, (31.3% identity in 294 aa
overlap). Regulated by MprA (Rv0981) under physiological
conditions and environmental stress (SDS and Triton X-100)
(See He et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv1057"
/db_xref="EnsemblGenomes-Tr:CCP43808"
/db_xref="InterPro:IPR011048"
/db_xref="InterPro:IPR015943"
/db_xref="UniProtKB/TrEMBL:O53405"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43808.1"
/translation="MSVMNGREVARESRDAQVFEFGTAPGSAVVKIPVQGGPIGGIAI
SRDGSLLVVTNNGTDTVSVVGTDTCRVTQTVTSVNEPFAIAMGNAEANRAYVSTVSSA
YDAIAVIDVATNTVLGTHPLALSVSDLTLSPDDKYLYVSRNGTRGADVAVLDTTTGAL
IDVVDVSQAPGTTTQCVRMSPDGSVLYVGANGPSGGLLVVITTRAQSDGGRIGSRSRS
RQKSSKPRGNQAAAGLRVVATIDIGSSVRDVALSPDGAIAYVASCGSDFGAVVDVIDT
RTHQITSSRAISEIGGLVTRVSVSGDADRAYLVSEDRVTVLCTRTHDVIGTIRTGQPS
CVVESPDGKYLYIADYSGTITRTAVASTIVSGTEQLALQRRGSMQWFSPELQQYAPAL
A"
gene 1180684..1182315
/gene="fadD14"
/locus_tag="Rv1058"
CDS 1180684..1182315
/codon_start=1
/transl_table=11
/gene="fadD14"
/locus_tag="Rv1058"
/product="Probable medium chain fatty-acid-CoA ligase
FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA
synthase)"
/note="Rv1058, (MTV017.11), len: 543 aa. Probable
fadD14,medium-chain fatty-acid-CoA synthetase, highly
similar to many e.g. CAC32346.1|AL583945 putative fatty
acid CoA ligase from Streptomyces coelicolor (558 aa);
N-terminus of NP_419738.1|NC_002696
medium-chain-fatty-acid--CoA ligase from Caulobacter
crescentus (1006 aa); Q00594|ALKK_PSEOL
medium-chain-fatty-acid--CoA ligase from Pseudomonas
oleovorans (546 aa), FASTA scores: opt: 1468, E():
0,(41.1% identity in 538 aa overlap); etc. Contains
PS00455 Putative AMP-binding domain signature. Belongs to
the ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv1058"
/db_xref="EnsemblGenomes-Tr:CCP43809"
/db_xref="GOA:O53406"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O53406"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43809.1"
/translation="MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEGYRHSSYRDV
GQRAGQLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQI
AYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAE
LIDAESPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGIGVG
SSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVP
TIWNDVMHYLEKDPDHDMSSLRLVACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSP
LATMAWPPPGTPDDQHWAFRITQGQPVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPW
IAGSYYGGRDESKFDSGWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENC
LIAHPDVLEAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT"
gene 1182391..1183455
/locus_tag="Rv1059"
CDS 1182391..1183455
/codon_start=1
/transl_table=11
/locus_tag="Rv1059"
/product="Conserved protein"
/note="Rv1059, (MTV017.12), len: 354 aa. Conserved
protein,similar to Rv0926c|MTCY21C12.20c hypothetical
protein from Mycobacterium tuberculosis (358 aa), FASTA
scores: opt: 338, E(): 1.4e-14, (33.1% identity in 363 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1059"
/db_xref="EnsemblGenomes-Tr:CCP43810"
/db_xref="GOA:O53407"
/db_xref="InterPro:IPR000846"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53407"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43810.1"
/translation="MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGK
DVGEIIGSPPLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVVTPLGW
FYPSEKEAAPLEVAAQAGNATLHGAGIGPGAVTELFPLLLSVMSTGVTFVRSEEFSDL
RSYGAPDVLRYVMGFGGTPDSALTGPMQKILDGGFLQSVRLCVDRLGFAADPQIRTSQ
EVAVATAPIDSPIGVIEPGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFG
PAGERYEIEVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAG
IQSFFDLPLITGRAAPGLAR"
gene 1183508..1183981
/locus_tag="Rv1060"
CDS 1183508..1183981
/codon_start=1
/transl_table=11
/locus_tag="Rv1060"
/product="Unknown protein"
/note="Rv1060, (MTV017.13), len: 157 aa. Unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1060"
/db_xref="EnsemblGenomes-Tr:CCP43811"
/db_xref="GOA:O53408"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O53408"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43811.1"
/translation="MAKSVVVEQSRAIPVQSEDAFGGTLAAALPVICSHWYGLIPPIK
EVRDQTGAWDSVGQARVITMVGGGRVREELTSVDPPRSFGYTLTDIKGPLAPLVALVE
GKWSFAPADTGTTVTWQWTIHPRSALAAPVLPVFARMWRGYARGVLEKLSALLVG"
gene 1184015..1184878
/locus_tag="Rv1061"
CDS 1184015..1184878
/codon_start=1
/transl_table=11
/locus_tag="Rv1061"
/product="Conserved protein"
/note="Rv1061, (MTV017.14), len: 287 aa. Conserved
protein,similar to hypothetical proteins from various
bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803
(304 aa),FASTA scores: opt: 245, E():1.2e-09, (27.1%
identity in 258 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1061"
/db_xref="EnsemblGenomes-Tr:CCP43812"
/db_xref="InterPro:IPR017932"
/db_xref="InterPro:IPR026869"
/db_xref="InterPro:IPR029055"
/db_xref="UniProtKB/TrEMBL:O53409"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43812.1"
/translation="MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFD
EHHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRI
FAHNGVVEGLDVLDERLREVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDAL
RWLAANVPIYAVNVLLSTATDVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHST
HLRERSSVVFATEPMDDNPRWRLLDAGELVHVDAALRVNRSLVLPDPPRHPIRREDLS
EPVLHAQHTSA"
gene 1184883..1185740
/locus_tag="Rv1062"
CDS 1184883..1185740
/codon_start=1
/transl_table=11
/locus_tag="Rv1062"
/product="Conserved hypothetical protein"
/note="Rv1062, (MTV017.15), len: 285 aa. Conserved
hypothetical protein, some similarity to AL079356|SC6G9_10
hypothetical protein in Streptomyces coelicolor (289
aa),FASTA scores: opt: 556, E(): 1.2e-27, (39.0% identity
in 287 aa overlap), and Z99111|BSUB0008_176 Bacillus
subtilis (260aa), FASTA scores: opt: 163, E(): 0.0013,
(27.4% identity in 179aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1062"
/db_xref="EnsemblGenomes-Tr:CCP43813"
/db_xref="GOA:O53410"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR016035"
/db_xref="UniProtKB/TrEMBL:O53410"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43813.1"
/translation="MTTRRALVLAGGGLAGIAWETGVLRGIADESPAAARLLLDSDVL
VGTSAGATVAAQISSGCPLDTLYERQLAETSAEIDPGVDIDAITDLFLTAVTEPHIST
RRRLQRIGAVALAVDTVPESVRRQVIAQRLPSHDWPDRVLRVTAIDIATGELVVFHRE
SNVALVDAVAASCSVPGAWPPVTIAGRRYMDGGVASSVNLGVADDCDAAVVLVPAGAD
APSPFGGGAAAEIAAATGMVFAVFADDDSLAAFGPNPLDPLCRVNSAMAGRQQGRREA
QAVARLLGV"
gene complement(1185741..1186823)
/locus_tag="Rv1063c"
CDS complement(1185741..1186823)
/codon_start=1
/transl_table=11
/locus_tag="Rv1063c"
/product="Conserved hypothetical protein"
/note="Rv1063c, (MTV017.16c), len: 360 aa. Conserved
hypothetical protein, similar to P37053|YCHK_ECOLI
hypothetical protein from Escherichia coli (314 aa), FASTA
scores: opt: 487, E(): 7.2e-23, (32.7% identity in 321 aa
overlap). Also partially similar to Rv3239c|MTCY20B11.14c.
Belongs to the UPF0028 (SWS) family."
/db_xref="EnsemblGenomes-Gn:Rv1063c"
/db_xref="EnsemblGenomes-Tr:CCP43814"
/db_xref="GOA:P9WIY9"
/db_xref="InterPro:IPR001423"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR016035"
/db_xref="UniProtKB/Swiss-Prot:P9WIY9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43814.1"
/translation="MPAPAALRVRGSSSPRVALALGSGGARGYAHIGVIQALRERGYD
IVGIAGSSMGAVVGGVHAAGRLDEFAHWAKSLTQRTILRLLDPSISAAGILRAEKILD
AVRDIVGPVAIEQLPIPYTAVATDLLAGKSVWFQRGPLDAAIRASIAIPGVIAPHEVD
GRLLADGGILDPLPMAPIAGVNADLTIAVSLNGSEAGPARDAEPNVTAEWLNRMVRST
SALFDVSAARSLLDRPTARAVLSRFGAAAAESDSWSQAPEIEQRPAGPPADREEAADT
PGLPKMGSFEVMNRTIDIAQSALARHTLAGYPADLLIEVPRSTCRSLEFHRAVEVIAV
GRALATQALEAFEIDDDESAAATIEG"
gene complement(1186904..1187323)
/gene="lpqV"
/locus_tag="Rv1064c"
CDS complement(1186904..1187323)
/codon_start=1
/transl_table=11
/gene="lpqV"
/locus_tag="Rv1064c"
/product="Possible lipoprotein LpqV"
/note="Rv1064c, (MTV017.17c), len: 139 aa. Possible
lipoprotein LpqV. Has N-terminal signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1064c"
/db_xref="EnsemblGenomes-Tr:CCP43815"
/db_xref="GOA:P9WK57"
/db_xref="InterPro:IPR020377"
/db_xref="UniProtKB/Swiss-Prot:P9WK57"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP43815.1"
/translation="MRPSRYAPLLCAMVLALAWLSAVAGCSRGGSSKAGRSSSVAGTL
PAGVVGVSPAGVTTRVDAPAESTEEEYYQACHAARLWMDAQPGSGESLIEPYLAVVQA
SPSGVAGSWHIRWAALTPARQAAVIVAARAAANAECG"
gene 1187435..1188001
/locus_tag="Rv1065"
CDS 1187435..1188001
/codon_start=1
/transl_table=11
/locus_tag="Rv1065"
/product="Conserved hypothetical protein"
/note="Rv1065, (MTV017.18), len: 188 aa. Conserved
hypothetical protein, some similarity to AL0209|SC4H8_11
hypothetical protein from Streptomyces coelicolor (182
aa),FASTA scores: opt: 156, E(): 0.0011, (31.3% identity
in 195 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1065"
/db_xref="EnsemblGenomes-Tr:CCP43816"
/db_xref="GOA:O53413"
/db_xref="InterPro:IPR010300"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR014710"
/db_xref="UniProtKB/TrEMBL:O53413"
/protein_id="CCP43816.1"
/translation="MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHL
LPDGGVPQTQRWYTRIHGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYR
WDGRRLRRRRLDAGDQAGFPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLT
AMSYYEITERNTLRRQRTELTDQPEGSG"
gene 1187998..1188393
/locus_tag="Rv1066"
CDS 1187998..1188393
/codon_start=1
/transl_table=11
/locus_tag="Rv1066"
/product="Conserved hypothetical protein"
/note="Rv1066, (MTV017.19), len: 131 aa. Conserved
hypothetical protein, strong similarity to AL0209|SC4H8.10
hypothetical protein from Streptomyces coelicolor (132
aa),FASTA scores: opt: 429, E(): 5.2e-23, (57.1% identity
in 119 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1066"
/db_xref="EnsemblGenomes-Tr:CCP43817"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR036873"
/db_xref="UniProtKB/TrEMBL:O53414"
/protein_id="CCP43817.1"
/translation="MSRIDRVLEAARRRYRRLAADQVPEAARRGAVLVDIRPQAQRAR
EGEVPGALVIERNVLEWRCDPTSDARLPQAVDDDVEWVILCSEGYTSSLAAASLLDLG
LHRATDVVGGYRALAAGGVLAELGGAVGG"
gene complement(1188421..1190424)
/gene="PE_PGRS19"
/locus_tag="Rv1067c"
CDS complement(1188421..1190424)
/codon_start=1
/transl_table=11
/gene="PE_PGRS19"
/locus_tag="Rv1067c"
/product="PE-PGRS family protein PE_PGRS19"
/note="Rv1067c, (MTV017.20c), len: 667 aa.
PE_PGRS19,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002). Similar to Rv3388|MTV004.46 M. tuberculosis
(731 aa), FASTA scores: opt: 2227, E(): 0, (55.6% identity
in 710 aa overlap). Contains PS00583 pfkB family of
carbohydrate kinases signature 1, probably fortuitous.
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1067c"
/db_xref="EnsemblGenomes-Tr:CCP43818"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FT3"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43818.1"
/translation="MSFVLVSPSQLMAAAADVAGIGSAISAANAAALAPTSVLAAAGA
DEVSAAVAALFSAHAGQYQQLGARAALFHEQFVQALTGAASAYASAEATNVEQQVLGL
INAPTQALLGRPLIGNGADGTAANPNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGL
IGNGGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAGGAGGAGGT
AGLFGNGGVGGVGGDGGQGGNGAGAGASGTKGGDAGAGGAGGAGGWIHGHGGAGGDGG
AGGAGGQASPGAPGPPSQPGGAGGAGGAGGRGGDGGSAGWLSGNGGDAGNGGGGGTAG
GAGNGGQFGGDGGTGGTGGTAGAGGNGGRGAVLFGHGGNAGHGGAGGNGAAAGAGGEH
VVATAGKGGTGGVGGDGGGGGAGGGGGLLYGNGGAGGAGNSGGDGGTGLNAALGGNGG
GGGVGGNAGAGGTGGSAGWLSGNGGAGGSGGSAGAGGAGGKGGDTPNGLAINPGIGGN
GGDTGNAGNGGNGGSAARLFGGGGAGGAGGTGSTAGSGGSGGTNPPTGLQAAGGNGGS
GHAGGHGGNGGGAGLLGGGGTGGNGGGGGQGGLGAAAGGVDGNGGNGGNGGKGGDAQL
VGDGGNGGNGGKGGAGLIAGLDGAGGAGGTRGLIFGNAGTPGQ"
gene complement(1190757..1192148)
/gene="PE_PGRS20"
/locus_tag="Rv1068c"
CDS complement(1190757..1192148)
/codon_start=1
/transl_table=11
/gene="PE_PGRS20"
/locus_tag="Rv1068c"
/product="PE-PGRS family protein PE_PGRS20"
/note="Rv1068c, (MTV017.21c), len: 463 aa.
PE_PGRS20,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002). Similar to AL021897|MTV017_19 Mycobacterium
tuberculosis H37Rv (667 aa), FASTA scores: opt: 1875, E():
0, (55.0% identity in 667 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1068c"
/db_xref="EnsemblGenomes-Tr:CCP43819"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIF9"
/protein_id="CCP43819.1"
/translation="MSYMIAVPDMLSSAAGDLASIGSSINASTRAAAAATTRLLPAAA
DEVSAHIAALFSGHGEGYQAIARQMAAFHDQFTLALTSSAGAYASAEATNVEQQVLGL
INAPTQALLGRPLIGNGADGTAANPNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGL
IGNGGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPAGAIGAPGVAGGAGGAGGT
AGLFGNGGAGGAGGAGGAGGRGGDGGSAGWLSGNGGDAGTGGGGGNAGNGGNGGSAGW
LSGNGGTGGGGGTAGAGGQGGNGNSGIDPGNGGQGADTGNAGNGGHGGSAAKLFGDGG
AGGAGGMGSTGGTGGGGGFGGGTGGNGGNGHAGGAGGSGGTAGLLGSGGSGGTGGDGG
NGGLGAGSGAKGNGGNGGDGGKGGDAQLIGNGGNGGNGGKGGTGLMPGINGTGGAGGS
RGQISGNPGTPGQ"
gene complement(1192510..1194273)
/locus_tag="Rv1069c"
CDS complement(1192510..1194273)
/codon_start=1
/transl_table=11
/locus_tag="Rv1069c"
/product="Conserved protein"
/note="Rv1069c, (MTV017.22c), len: 587 aa. Conserved
protein, hydrophobic regions in N-terminal domain. Similar
in part to O07136|B1306.04C B1306.04c protein from
Mycobacterium leprae (89 aa), FASTA scores: opt: 229, E():
1.3e-07, (54.2% identity in 72 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1069c"
/db_xref="EnsemblGenomes-Tr:CCP43820"
/db_xref="GOA:O53417"
/db_xref="InterPro:IPR012037"
/db_xref="InterPro:IPR027787"
/db_xref="InterPro:IPR027788"
/db_xref="UniProtKB/TrEMBL:O53417"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43820.1"
/translation="MTEPAAATTTNASDEPATGAEQAVDTAATPQTPEPQPIRSTWWI
RHYTFTGTAMGLVFVWFSMTPSLLPRGPLFQGLVSGICGAFGYGLGVFAVWLVRYMRS
HNSSPPPPRWAWPPLIAVGAVGMVGMAVQFHVWQDDVRDLMGVEHLRWYDYPLAAALS
LVVLFTLVEIGQFIRWLFRFLVGQVDRIAPFRVSAAIVVVLLVVLTITLLNGVVLKFA
MNSMNSTFAAVNNEMNPDSAPPKTPLRSGGPGSLVSWESLGHQGRIFVHSGPTIADLT
AFNGTPAVEPIRTYAGLNSADGIMATAELAARELARTGGLRRAVVAVATSTGTGWINE
AEASALEYMYNGDTAIVSMQYSFLPSWLSFLVDKENARHAGEALFEAVDKLIRQLPES
QRPKLVVFGESLGSFGGEAPFMNLNNILARTDGALFSGPTFNNTVWNSLTANRDAGSP
QWLPIYDDGRNVRFVARARDLQRPDAPWGRPRVVYLQHASDPIAWWTPRLLFREPDWL
REQRGYDVLPQTRWIPVVTFVQVSADMAVATHVPDGHGHRYVATVADGWAAVLSPPGW
TQQKTERLQPLLHANAKPFGS"
gene complement(1194270..1195043)
/gene="echA8"
/locus_tag="Rv1070c"
CDS complement(1194270..1195043)
/codon_start=1
/transl_table=11
/gene="echA8"
/locus_tag="Rv1070c"
/product="Probable enoyl-CoA hydratase EchA8 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv1070c, (MTV017.23c), len: 257 aa. Probable
echA8,enoyl-CoA hydratase, equivalent to O07137|B1306.05c
putative enoyl-CoA hydratase/isomerase from Mycobacterium
leprae (257 aa), FASTA scores: opt: 1417, E(): 0, (86.4%
identity in 257 aa overlap). Also highly similar to others
e.g. NP_106219.1|NC_002678 enoyl CoA hydratase from
Mesorhizobium loti (257 aa); L39265|RHMRPST_2 enoyl-CoA
hydratase from Rhizobium melilotii (257 aa), FASTA scores:
opt: 1100, E(): 0, (66.9% identity in 257 aa overlap);
AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA hydratase
from Pseudomonas putida (257 aa); etc. Contains PS00166
Enoyl-CoA hydratase/isomerase signature. Belongs to the
enoyl-CoA hydratase/isomerase family."
/db_xref="EnsemblGenomes-Gn:Rv1070c"
/db_xref="EnsemblGenomes-Tr:CCP43821"
/db_xref="GOA:P9WNN9"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="PDB:3H81"
/db_xref="PDB:3PZK"
/db_xref="PDB:3Q0G"
/db_xref="PDB:3Q0J"
/db_xref="PDB:4FJW"
/db_xref="UniProtKB/Swiss-Prot:P9WNN9"
/inference="protein motif:PROSITE:PS00166"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43821.1"
/translation="MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELD
DDPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTADFFATWGKLAAVRTPTIAAVA
GYALGGGCELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLIL
TGRTMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESS
LSEGLLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR"
gene complement(1195055..1196092)
/gene="echA9"
/locus_tag="Rv1071c"
CDS complement(1195055..1196092)
/codon_start=1
/transl_table=11
/gene="echA9"
/locus_tag="Rv1071c"
/product="Possible enoyl-CoA hydratase EchA9 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv1071c, (MTV017.24c), len: 345 aa. Possible
echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306.06c
putative enoyl-CoA hydratase/isomerase from Mycobacterium
leprae (345 aa), FASTA scores: opt: 1799, E(): 0, (77.7%
identity in 345 aa overlap). Also similar to many
eukaryotic and prokaryotic enoyl-CoA hydratases e.g.
NP_437984.1|NC_003078 putative enoyl-CoA hydratase protein
from Sinorhizobium meliloti (356 aa);
NP_420165.1|NC_002696 enoyl-CoA hydratase/isomerase family
protein from Caulobacter crescentus (350 aa); Q19278
protein similar to enoyl-CoA hydratases from
Caenorhabditis elegans (386),FASTA scores: opt: 787, E():
0, (38.5% identity in 348 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1071c"
/db_xref="EnsemblGenomes-Tr:CCP43822"
/db_xref="GOA:O53419"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR032259"
/db_xref="UniProtKB/TrEMBL:O53419"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43822.1"
/translation="MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMS
WEHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKDGVEARRFWRHEYLLNALIGRFA
KPYVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGA
LGLHAALTGAPFSGADAIALGFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPS
TLAAQRDWIDECYAGDSVADIVAALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRA
AKLDTLEDVLIQDYRVSSASLRSHDLVEGIRAQLIDKDRNPNWSPATLDAITAADIEA
YFEPVDDDLSF"
gene 1196279..1197115
/locus_tag="Rv1072"
CDS 1196279..1197115
/codon_start=1
/transl_table=11
/locus_tag="Rv1072"
/product="Probable conserved transmembrane protein"
/note="Rv1072, (MTV017.25), len: 278 aa. Probable
conserved transmembrane protein, equivalent to
O07139|B1306.07|Y13803 Protein B1306.07 from Mycobacterium
leprae (220 aa), FASTA scores: opt:1032, E(): 0, (75.0%
identity in 220 aa overlap); and at the C-terminal end to
Q50056|U1740D Mycobacterium leprae (96 aa), FASTA scores:
opt: 381, E(): 1.2e-18, (71.6% identity in 81 aa overlap).
Similar to Q54192|M80628|STMBLDA_1 transfer RNA-LEU (BLDA)
gene and ORF from Streptomyces griseus (293 aa), FASTA
scores: opt:558, E(): 4.7e-30, (41.5% identity in 299 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1072"
/db_xref="EnsemblGenomes-Tr:CCP43823"
/db_xref="GOA:O53420"
/db_xref="InterPro:IPR010539"
/db_xref="UniProtKB/TrEMBL:O53420"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43823.1"
/translation="MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAK
ATRPLTIDDVVTKTGLTLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVAT
FGRKQDNPAIVLSYAALEGLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGML
VVYKTGAIRVTPKFTRMVVAALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIF
SLVCIGIAAFSFLIDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQ
NE"
gene 1197231..1198082
/locus_tag="Rv1073"
CDS 1197231..1198082
/codon_start=1
/transl_table=11
/locus_tag="Rv1073"
/product="Conserved hypothetical protein"
/note="Rv1073, (MTV017.26), len: 283 aa. Conserved
hypothetical protein, similar to several hypothetical
mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03
Mycobacterium tuberculosis (339 aa), FASTA scores: opt:
810, E(): 0, (47.4% identity in 272 aa overlap);
Rv3555c|Z92774|MTCY6G11_2 Mycobacterium tuberculosis (289
aa), FASTA scores: opt: 704, E(): 0, (44.4% identity in
259 aa overlap); and Rv3517, etc., and GIR10|AF002133_10
Mycobacterium avium strain GIR10 (346 aa), FASTA scores:
opt: 802, E(): 0, (48.1% identity in 270 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1073"
/db_xref="EnsemblGenomes-Tr:CCP43824"
/db_xref="GOA:O53421"
/db_xref="UniProtKB/TrEMBL:O53421"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43824.1"
/translation="MGAQPFIGSEALAAGLISWHELGKYYTAIMPNVYLDKRLKPSLR
QRVIAAWLWSGRKGVIAGASASALHGAKWVDDHALVELIWRNARAPNGVRTKDELLLD
GEVQRLCGLTVTTVERTAFDLGRRPPLGQAITRLDALANATDFKINDVRELARKHPHT
RGLRQLDKALDLVDPGAQSPKETWLRLLLINAGFPRPSTQIPLLGVYGHPKYFLDMGW
EDIMLAVEYDGEQHRLSRDQFVKDVERLEYIRRAGWTHIRVLADHKGPDVVRRVRQAW
DTLTSRR"
gene complement(1198156..1199373)
/gene="fadA3"
/locus_tag="Rv1074c"
CDS complement(1198156..1199373)
/codon_start=1
/transl_table=11
/gene="fadA3"
/locus_tag="Rv1074c"
/product="Probable beta-ketoacyl CoA thiolase FadA3"
/note="Rv1074c, (MTV017.27c), len: 405 aa. Probable
fadA3,beta-ketoacyl CoA thiolase, highly similar to many
involved in beta-oxidation e.g. CAB89028.1|AL353870
beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor
(395 aa); P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA
thiolase from Escherichia coli (401 aa), FASTA scores:
opt: 1034, E(): 5.4e-56, (43.5% identity in 416 aa
overlap) and X97452 acetyl-CoA acetyltransferase
(thiolase) from Escherichia coli (401 aa), FASTA scores:
opt: 1043, E(): 0,(43.4% identity in 415 aa overlap);
Q43935|CATF_ACICA beta-ketoadipyl CoA thiolase from
Acinetobacter calcoaceticus (401 aa), FASTA scores: opt:
992, E(): 0,(41.5% identity in 415 aa overlap); etc.
Contains PS00737 Thiolases signature 2, and PS00445 FGGY
family of carbohydrate kinases signature 2, although this
is probably fortuitous. Belongs to the thiolase family."
/db_xref="EnsemblGenomes-Gn:Rv1074c"
/db_xref="EnsemblGenomes-Tr:CCP43825"
/db_xref="GOA:O53422"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020613"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/TrEMBL:O53422"
/inference="protein motif:PROSITE:PS00737"
/inference="protein motif:PROSITE:PS00445"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43825.1"
/translation="MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPA
LNPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDFLPGTTVNRYCSSSLQTTRMAFH
AIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPR
TDQKLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVT
LPDGTTVSTDDGPRPGTTYEKVSELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKA
KELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAFAVQ
VLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVG
GGQGMAMVIERLA"
gene complement(1199426..1200370)
/locus_tag="Rv1075c"
CDS complement(1199426..1200370)
/codon_start=1
/transl_table=11
/locus_tag="Rv1075c"
/product="Conserved exported protein"
/note="Rv1075c, (MTV017.28c), len: 314 aa. Possibly
exported protein, as it contains a N-terminal signal
sequence, hydrophobic domain from aa 7-25. Similar to
U15183|MLU15183_2 Mycobacterium leprae cosmid B1740 (106
aa), FASTA scores: opt: 207, E(): 1.6e-06, (42.6% identity
in 101 aa overlap). Also weak similarity to many
glyceraldehyde-3-phosphate dehydrogenases e.g.
Q41595|G3PC_TAXBA Taxus baccata (340 aa), FASTA scores:
opt: 147, E(): 0.027, (27.5% identity in 189 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1075c"
/db_xref="EnsemblGenomes-Tr:CCP43826"
/db_xref="GOA:O53423"
/db_xref="InterPro:IPR013830"
/db_xref="InterPro:IPR036514"
/db_xref="UniProtKB/TrEMBL:O53423"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43826.1"
/translation="MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSF
DAPPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGL
AEQTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPS
AQRLADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAA
GGVPVPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPI
HETPSRPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG"
gene 1200767..1201660
/gene="lipU"
/locus_tag="Rv1076"
CDS 1200767..1201660
/codon_start=1
/transl_table=11
/gene="lipU"
/locus_tag="Rv1076"
/product="Possible lipase LipU"
/note="Rv1076, (MTV017.29), len: 297 aa. Possible
lipU,lipase, very similar to several Mycobacterium
tuberculosis proteins e.g. Z95390|Rv3487c|MTCY13E12.41c
(277 aa), FASTA scores: opt: 1225, E(): 0, (76.0% identity
in 246 aa overlap); Rv1426c, etc. Also similar to
esterases and lipases of around 300 aa e.g. Q44087
esterase precursor from Acinetobacter lwoffii esterase
(303), FASTA scores: opt: 427, E(): 1.9e-21, (32.5%
identity in 280 aa overlap). Equivalent to
AL035159|MLCB1450 _7 Mycobacterium leprae (335 aa), FASTA
scores: opt: 1588, E(): 0, (79.7% identity in 296 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1076"
/db_xref="EnsemblGenomes-Tr:CCP43827"
/db_xref="GOA:O53424"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR033140"
/db_xref="UniProtKB/TrEMBL:O53424"
/protein_id="CCP43827.1"
/translation="MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPASTTVRAAVSLP
NASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSKFADSPVLVVDY
RLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSAGGYLALALAQRLQEVGEEP
AALVAISPLLQLAKEHKQAHPNIKTDAMFPARAFDALDALVASAAARNQVDGEPEELY
EPLEHITPGLPRTLIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAAS
MLPEAIRSLRQIGEYIREATG"
gene 1201717..1203111
/gene="cbs"
/gene_synonym="cysM2"
/locus_tag="Rv1077"
CDS 1201717..1203111
/codon_start=1
/transl_table=11
/gene="cbs"
/gene_synonym="cysM2"
/locus_tag="Rv1077"
/product="Probable cystathionine beta-synthase Cbs (serine
sulfhydrase) (beta-thionase) (hemoprotein H-450)"
/note="Rv1077, (MTV017.30), len: 464 aa. Probable cbs
(previously cysM2), cystathionine beta-synthase, similar
throughout its length to many eukaryotic cystathionine
beta-synthases e.g. P32232|CBS_RAT cystathionine
beta-synthase (560 aa), FASTA scores: opt: 951, E():
0,(40.2% identity in 450 aa overlap); also similar in
N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK
Mycobacterium tuberculosis (310 aa), FASTA scores: opt:
855, E(): 0, (46.8% identity in 314 overlap); and other
cysteine synthase proteins e.g. Rv1336, Rv0848, etc.
Contains PS00217 Sugar transport proteins signature 2
probably spurious. Belongs to the cysteine
synthase/cystathionine beta-synthase family."
/db_xref="EnsemblGenomes-Gn:Rv1077"
/db_xref="EnsemblGenomes-Tr:CCP43828"
/db_xref="GOA:P9WP51"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR005857"
/db_xref="InterPro:IPR036052"
/db_xref="UniProtKB/Swiss-Prot:P9WP51"
/inference="protein motif:PROSITE:PS00217"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43828.1"
/translation="MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSK
DRIAVKMIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDK
RNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHYVT
TGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRIVGADPEGSVYSGGAG
RPYLVEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVA
ALKVAEEAGPDALIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVL
RRKSGALPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELL
SAVFEGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVGVITR
YDLLGFLSEGAGRR"
gene 1203313..1204035
/gene="pra"
/locus_tag="Rv1078"
CDS 1203313..1204035
/codon_start=1
/transl_table=11
/gene="pra"
/locus_tag="Rv1078"
/product="Probable proline-rich antigen homolog Pra"
/note="Rv1078, (MTV017.31), len: 240 aa. Probable
pra,Proline-rich antigen homolog, equivalent to
X65546|MLPRAG_1 proline rich antigen from Mycobacterium
leprae (249 aa),FASTA scores: opt: 1162, E(): 3.3e-30,
(64.8% identity in 253 aa overlap). Has potential
hydrophobic domains."
/db_xref="EnsemblGenomes-Gn:Rv1078"
/db_xref="EnsemblGenomes-Tr:CCP43829"
/db_xref="GOA:P9WIM7"
/db_xref="InterPro:IPR010432"
/db_xref="UniProtKB/Swiss-Prot:P9WIM7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43829.1"
/translation="MTEQPPPGGSYPPPPPPPGPSGGHEPPPAAPPGGSGYAPPPPPS
SGSGYPPPPPPPGGGAYPPPPPSAGGYAPPPPGPAIRTMPTESYTPWITRVLAAFIDW
APYVVLVGIGWVIMLVTQTSSCVTSISEYDVGQFCVSQPSMIGQLVQWLLSVGGLAYL
VWNYGYRQGTIGSSIGKSVLKFKVVSETTGQPIGFGMSVVRQLAHFIDAIICFVGFLF
PLWDAKRQTLADKIMTTVCVPI"
gene 1204067..1205233
/gene="metB"
/locus_tag="Rv1079"
CDS 1204067..1205233
/codon_start=1
/transl_table=11
/gene="metB"
/locus_tag="Rv1079"
/product="Cystathionine gamma-synthase MetB (CGS)
(O-succinylhomoserine [thiol]-lyase)"
/note="Rv1079, (MTV017.32), len: 388 aa.
metB,cystathionine gamma-synthase (see citation below).
P46807|METB_MYCLE cystathionine gamma-synthase from
Mycobacterium leprae (388 aa), FASTA scores: opt:
2220,E(): 0, (87.3% identity in 387 aa overlap). Also
similar to other Mycobacterium tuberculosis enzymes
involved in methionine synthesis e.g. Rv0391 and Rv3340.
Contains PS00868 Cys/Met metabolism enzymes
pyridoxal-phosphate attachment site. Belongs to the
trans-sulfuration enzymes family."
/db_xref="EnsemblGenomes-Gn:Rv1079"
/db_xref="EnsemblGenomes-Tr:CCP43830"
/db_xref="GOA:P9WGB7"
/db_xref="InterPro:IPR000277"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WGB7"
/inference="protein motif:PROSITE:PS00868"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43830.1"
/translation="MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQ
DGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGD
HVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPL
LSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVG
GALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFL
ADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILA
ESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG"
gene complement(1205304..1205798)
/gene="greA"
/locus_tag="Rv1080c"
CDS complement(1205304..1205798)
/codon_start=1
/transl_table=11
/gene="greA"
/locus_tag="Rv1080c"
/product="Probable transcription elongation factor GreA
(transcript cleavage factor GreA)"
/note="Rv1080c, (MTV017.33c), len: 164 aa. Probable
greA,transcription elongation factor G, closest to
P46808|GREA_MYCLE transcription elongation factor G from
Mycobacterium leprae (202 aa), FASTA scores: opt:
1005,E(): 0, (94.5% identity in 164 aa overlap); and
similar to many e.g. P21346|GREA_ECOLI from Escherichia
coli (158 aa),FASTA scores: opt: 257, E(): 5.7e-10, (37.2%
identity in 148 aa overlap); etc. Contains two PS00829 and
one PS00830 Prokaryotic transcription elongation factors
signatures 1 and 2, respectively. Belongs to the GREA/GREB
family."
/db_xref="EnsemblGenomes-Gn:Rv1080c"
/db_xref="EnsemblGenomes-Tr:CCP43831"
/db_xref="GOA:P9WMT9"
/db_xref="InterPro:IPR001437"
/db_xref="InterPro:IPR006359"
/db_xref="InterPro:IPR018151"
/db_xref="InterPro:IPR022691"
/db_xref="InterPro:IPR023459"
/db_xref="InterPro:IPR028624"
/db_xref="InterPro:IPR036805"
/db_xref="InterPro:IPR036953"
/db_xref="UniProtKB/Swiss-Prot:P9WMT9"
/inference="protein motif:PROSITE:PS00830"
/inference="protein motif:PROSITE:PS00829"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43831.1"
/translation="MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDL
RENGGYHAAREEQGQQEARIRQLQDLLSNAKVGEAPKQSGVALPGSVVKVYYNGDKSD
SETFLIATRQEGVSDGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGSTVSVTLVSAE
PYHS"
gene complement(1205984..1206418)
/locus_tag="Rv1081c"
CDS complement(1205984..1206418)
/codon_start=1
/transl_table=11
/locus_tag="Rv1081c"
/product="Probable conserved membrane protein"
/note="Rv1081c, (MTV017.34c), len: 144 aa. Probable
conserved membrane protein, with hydrophobic stretch from
aa 26 - 48, highly similar to NP_302548.1|NC_002677
conserved membrane protein from Mycobacterium leprae. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004). Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1081c"
/db_xref="EnsemblGenomes-Tr:CCP43832"
/db_xref="GOA:O53429"
/db_xref="InterPro:IPR025443"
/db_xref="UniProtKB/TrEMBL:O53429"
/protein_id="CCP43832.1"
/translation="MTHTPIPRPDARYGRPRLSRRARRRVAIALGVLVAAAGIVIAVI
GYQRISTSAVTGSLVGYRLVDDETASVTISVTRSDPSRPVACIVRVRATNGSETGRRE
LLVPPSEATTVQVTTTVKSSQPPVMADVYGCGTEVPSYLRLP"
gene 1206520..1207386
/gene="mca"
/locus_tag="Rv1082"
CDS 1206520..1207386
/codon_start=1
/transl_table=11
/gene="mca"
/locus_tag="Rv1082"
/product="Mycothiol conjugate amidase Mca (mycothiol
S-conjugate amidase)"
/note="Rv1082, (MTV017.35), len: 288 aa. Mca, mycothiol
conjugate amidase (see citation below), equivalent to
NP_302547.1|NC_002677 conserved hypothetical protein from
Mycobacterium leprae (290 aa), FASTA scores: opt:
1737,E(): 0, (86.4% identity in 287 aa overlap); and
similar to Q54358|X79146 lmbE protein from Streptomyces
lincolnensis (270 aa). Also similar to
Rv1170|MTV005.06|MSHB GlcNAc-Ins deacetylase from
Mycobacterium tuberculosis (303 aa), FASTA scores: opt:
411, E(): 9.4e-20, (35.8% identity in 299 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1082"
/db_xref="EnsemblGenomes-Tr:CCP43833"
/db_xref="GOA:P9WJN1"
/db_xref="InterPro:IPR003737"
/db_xref="InterPro:IPR017811"
/db_xref="InterPro:IPR024078"
/db_xref="UniProtKB/Swiss-Prot:P9WJN1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43833.1"
/translation="MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGER
GEILNPAMDLPDVHGRIAEIRRDEMTKAAEILGVEHTWLGFVDSGLPKGDLPPPLPDD
CFARVPLEVSTEALVRVVREFRPHVMTTYDENGGYPHPDHIRCHQVSVAAYEAAGDFC
RFPDAGEPWTVSKLYYVHGFLRERMQMLQDEFARHGQRGPFEQWLAYWDPDHDFLTSR
VTTRVECSKYFSQRDDALRAHATQIDPNAEFFAAPLAWQERLWPTEEFELARSRIPAR
PPETELFAGIEP"
gene 1207383..1207649
/locus_tag="Rv1083"
CDS 1207383..1207649
/codon_start=1
/transl_table=11
/locus_tag="Rv1083"
/product="Conserved hypothetical protein"
/note="Rv1083, (MTV017.36), len: 88 aa. Conserved
hypothetical protein, similar to U15183|MLU15183_9
hypothetical protein from Mycobacterium leprae (167
aa),FASTA scores: opt: 332, E(): 1.2e-13, (58.4% identity
in 101 aa overlap). Hydrophobic domain aa 25-43. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1083"
/db_xref="EnsemblGenomes-Tr:CCP43834"
/db_xref="GOA:O53431"
/db_xref="UniProtKB/TrEMBL:O53431"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43834.1"
/translation="MNQILLSVIAEGGPGNTGPDFGKASPVGLLVIVLLVIATLFLVR
SMNQQLKKVPKSFDRDHPELDQAADEGTDRDGPARPPGPPHESG"
gene 1207636..1209657
/locus_tag="Rv1084"
CDS 1207636..1209657
/codon_start=1
/transl_table=11
/locus_tag="Rv1084"
/product="Conserved protein"
/note="Rv1084, (MTV017.37), len: 673 aa. Conserved
protein,similar to P37512|YYAL_BACSU hypothetical protein
from Bacillus subtilis (689 aa), FASTA scores: opt: 1063,
E() : 0, (36.5% identity in 696 aa overlap);
AE0009|AE000983_10 Archaeoglobus fulgidus section 1 (642
aa), FASTA scores: opt: 1018, E(): 0, (37.2% identity in
600 aa overlap). Also similar to AE001938|AE001938_9
Deinococcus radiodurans (690 aa), FASTA scores: opt: 1097,
E(): 0, (41.6% identity in 694 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1084"
/db_xref="EnsemblGenomes-Tr:CCP43835"
/db_xref="GOA:O53432"
/db_xref="InterPro:IPR004879"
/db_xref="InterPro:IPR008928"
/db_xref="InterPro:IPR012341"
/db_xref="InterPro:IPR024705"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:O53432"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43835.1"
/translation="MSPANPSGTNTLALATSPYLRQHADNPVHWQQWTPQALAEAAAR
AVPILLSVGYAACHWCHVMAHESFDDDEVAAAMNAGFVCIKVDREERPDIDAVYMNAT
VALTGQGGWPMTCFLTPNGRPFFCGTYYPKAAFLQLLSAISETWRERRAEVEQASDHI
AAELRSMASGLPGGGPEVAPELCDDAVAGVLREQDTAHGGFGGAPKFPPSALLEALMR
HYERTRSPAALEAVARTGNAMARGGIYDQLGGGFARYSVDGAWVVPHFEKMLYDNALL
LRAYAHWARRTGDPLARRVAAQTARFLLDELGSKAPADMFTSSLDADADGREGSTYVW
TPVQLTEVLGGDDGRWAAEVFGVTEAGTFEHGTSVLQLPADPDDAARLDRVRAALLVA
RLARAQPARDDKVVTSWNGLAITALAEASVALDDPALAHAARRCATRLLDLHVVDGRL
RRASLGGVVGDSAAILEDHAMLATGLLALYQLTSEGAWLTAATGLLDTAVAHFGDPQR
PGRWFDTADDAERLMLRPSDPLDGATPSGASSIAEALLTAGHVVDGARAERYWQLAAD
TLRAHAVLLARAPRSAGHWLAVAEAVVRGPLQIAVACDLPRSSLLADARRLAPGGAIV
VGGAAGSSALLVGRDRVAGADAAYVCRGRVCDLPVTSAAELATALGVPG"
gene complement(1209756..1210484)
/locus_tag="Rv1085c"
CDS complement(1209756..1210484)
/codon_start=1
/transl_table=11
/locus_tag="Rv1085c"
/product="Possible hemolysin-like protein"
/note="Rv1085c, (MTV017.38c), len: 242 aa. Possible
hemolysin-like protein, integral membrane protein, similar
to many hemolysins, and hypothetical proteins e.g.
U28375|ECU28375_49 Hypothetical protein from Escherichia
coli (219 aa), FASTA scores: opt: 308, E(): 7.5e-15,
(30.6% identity in 180 aa overlap); AE0011|HIAE001124_2
Hypothetical protein from Borrelia burgdorferi (233
aa),FASTA scores: opt: 305, E(): 1.3e-14, (25.6% identity
in 203 aa overlap). Also weakly similar to
HLY3_BACCE|P54176 haemolysin from Bacillus cereus (219
aa), FASTA scores: opt: 247, E(): 8.7e-12, (27.5% identity
in 171 aa overlap). Also similar to AE002027|AE002027_8
probable hemolysin from Deinococcus radiodurans (219 aa),
FASTA scores: opt: 354,E(): 1.8e-16, (31.1% identity in
219 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1085c"
/db_xref="EnsemblGenomes-Tr:CCP43836"
/db_xref="GOA:P9WFN7"
/db_xref="InterPro:IPR004254"
/db_xref="InterPro:IPR005744"
/db_xref="UniProtKB/Swiss-Prot:P9WFN7"
/protein_id="CCP43836.1"
/translation="MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYS
AGTAVLAGASLVAVSWAVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWM
KRADHSMIFVFIAGSYTPFALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVG
VPLYLLLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGY
HEFFHACTAVAAICHYIAMWFVVF"
gene 1210595..1211383
/locus_tag="Rv1086"
CDS 1210595..1211383
/codon_start=1
/transl_table=11
/locus_tag="Rv1086"
/product="Short (C15) chain Z-isoprenyl diphosphate
synthase (Z-FPP synthase) (Z-farnesyl diphosphate
synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate
synthetase) (geranyltranstransferase) (farnesyl
pyrophosphate synthetase)"
/note="Rv1086, (MTV017.39), len: 262 aa. Short (C15) chain
Z-isoprenyl diphosphate synthase (see citations
below),equivalent to NP_302598.1|NC_002677 possible
undecaprenyl pyrophosphate synthetase from Mycobacterium
leprae (262 aa), similar to many hypothetical proteins and
several potential members of the upp synthase family e.g.
NP_296167.1|NC_001263 undecaprenyl diphosphate synthase
from Deinococcus radiodurans (339 aa); P20182|YT14_STRFR
Hypothetical protein from Streptomyces fradiae (259
aa),FASTA scores: opt: 840, E(): 0, (51.0% identity in 259
aa overlap); and P38118|YARF_CORGL Hypothetical protein
from Corynebacterium glutamicicum (234 aa), FASTA scores:
opt: 729, E(): 0, (56.0% identity in 209 aa overlap); etc.
Also similar to Rv2361c|MTCY27.19 (296 aa) (35.6% identity
in 233 aa overlap). Contains PS01066 Uncharacterized
protein family UPF0015 signature. Seems to belong to the
UPP synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv1086"
/db_xref="EnsemblGenomes-Tr:CCP43837"
/db_xref="GOA:P9WFF5"
/db_xref="InterPro:IPR001441"
/db_xref="InterPro:IPR018520"
/db_xref="InterPro:IPR036424"
/db_xref="PDB:2VFW"
/db_xref="PDB:2VG0"
/db_xref="PDB:2VG1"
/db_xref="UniProtKB/Swiss-Prot:P9WFF5"
/inference="protein motif:PROSITE:PS01066"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43837.1"
/translation="MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRR
WARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIE
IITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGG
RREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRL
SGFLLWQSAYSEMWFTEAHWPAFRHVDFLRALRDYSARHRSYGR"
gene 1211560..1213863
/gene="PE_PGRS21"
/locus_tag="Rv1087"
CDS 1211560..1213863
/codon_start=1
/transl_table=11
/gene="PE_PGRS21"
/locus_tag="Rv1087"
/product="PE-PGRS family protein PE_PGRS21"
/note="Rv1087, (MTV017.40), len: 767 aa. PE_PGRS21, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below).
Similar to Rv1090|AL021897|MTV017_43 Mycobacterium
tuberculosis H37Rv (853 aa), FASTA scores: opt: 2819, E():
0, (59.8% identity in 860 aa overlap). Contains PS00583
pfkB family of carbohydrate kinases signature 1 near C
-terminus. Predicted to be an outer membrane protein (See
Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1087"
/db_xref="EnsemblGenomes-Tr:CCP43838"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FT0"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43838.1"
/translation="MSFVVVAPEVLAAAASDLAGIGSTLAQANAAALAPTTAVLAAGA
DEVSAAIASLFGAHGQAYQAVSAQMSAFHAQFMQALTGAGGAYAAAEAVNVSAAQSVE
QDLLAAINARFERIFGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTVGMAGGNG
GAAGLIGNGGFGGGGGPGAAGGNGGAGGWLFGNGGAGGAGGLGVAPGVPGGAGGAGGA
GGVGGPAGLWGHGGAGGAGGAGVAGAGGFEGTIGAGGAGGVGGAGGVGGAGGAGGWLY
GDAGAGGDGGVGGAGGTGGLGNRGGAGGAGGAGGVGGAGGAAGLWGGGGAGGVGGTGG
GAGLGAQSVTFSSSLSGLSGGDGGAGGAGGAGGAGGTGGWLYGGGGAAGSGGDGGTGG
QGGAGGAGVFSLFGSGGGPGGNGGVGGVGGVGGAGGRAGLFGVGGLGGAGGDAGDSGE
GGFGGPGLAGGLFGNPGNGGVGGIGGDAAAGGAGGAGGNGGAGGNGGWLFGNGGAGGS
GGDGGAAGRGGAGNLGSAGGINAPAGNPGSGSVGIGGAGGAGGTAGLFGDGGAGGAGG
AGAAGGFGGISAATPSAGSEGAMGGAGGVGGNARLLGTGGAGGVGGGGGAGGDGGRGG
VATPGGQGGDAGDGGAGGAGGNGGGASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGP
TNFGLNGAGGGGGVGGNGATGPWLFGDGGPTPGSTGAGAAGGHGGDAQLIGNGGHGGA
GGTGVPNGSGGAGGLSGLLFGEPGANG"
gene 1214040..1214360
/locus_tag="Rv1087A"
CDS 1214040..1214360
/codon_start=1
/transl_table=11
/locus_tag="Rv1087A"
/product="Conserved hypothetical protein"
/note="Rv1087A, len: 106 aa (fragment). Conserved
hypothetical protein, highly similar to C-terminus of near
ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 short (C15)
chain Z-isoprenyl diphosphate synthase from Mycobacterium
tuberculosis (262 aa), FASTA scores: opt: 200, E():
1.1e-06, (57.9% identity in 76 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1087A"
/db_xref="EnsemblGenomes-Tr:CCP43839"
/db_xref="GOA:L7N654"
/db_xref="InterPro:IPR001441"
/db_xref="InterPro:IPR036424"
/db_xref="UniProtKB/TrEMBL:L7N654"
/protein_id="CCP43839.1"
/translation="MPCVGYGDRREFVDAVAVEAICENLNTSGQPDPDLVIRTSGEQR
LSGHRGPTGGVSRRRLLRALRDYSTPHASIPYVPPPYRSDGIHASRLAVESVFDALAG
RVEL"
gene 1214513..1214947
/gene="PE9"
/locus_tag="Rv1088"
CDS 1214513..1214947
/codon_start=1
/transl_table=11
/gene="PE9"
/locus_tag="Rv1088"
/product="PE family protein PE9"
/note="Rv1088, (MTV017.41), len: 144 aa. PE9, Member of
Mycobacterium tuberculosis PE family (see citation
below),similar to many others e.g. Z96071|MTCI418B_6
Mycobacterium tuberculosis cosmid (487 aa), FASTA scores:
opt: 318, E(): 7.3e-14, (60.9% identity in 87 aa overlap)
- except it appears to be frameshifted around codon 84. No
error to account for frameshift could be found."
/db_xref="EnsemblGenomes-Gn:Rv1088"
/db_xref="EnsemblGenomes-Tr:CCP43840"
/db_xref="GOA:Q79FS8"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:Q79FS8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43840.1"
/translation="MSYMIATPAALTAAATDIDGIGSAVSVANAAAVAATTGVLAAGG
DEVLAAIARLFNANAEEYHALSAQVAAFQTLFVRTLTGGCGVFRRRRGRQCVTAAEHR
AAGAGRRQRRRRSGDGQWRLRQQRHFGCGGQPEFRQHSEHRR"
gene <1214769..1215131
/gene="PE10"
/locus_tag="Rv1089"
CDS <1214769..1215131
/codon_start=1
/transl_table=11
/gene="PE10"
/locus_tag="Rv1089"
/product="PE family protein PE10"
/note="Rv1089, (MTV017.42), len: 120 aa. PE10, Member of
the Mycobacterium tuberculosis PE family of glycine-rich
proteins (see citation below). Partial ORF that appears to
be frameshifted continuation of Rv1088|MTV017.41. Sequence
has been checked and appears correct. Similar to
Z95555|MTCY06F7_4 Mycobacterium tuberculosis cosmid (401
aa), FASTA scores: opt:126, E(): 2, (29.6% identity in 125
aa overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1089"
/db_xref="EnsemblGenomes-Tr:CCP43841"
/db_xref="GOA:L0T5T4"
/db_xref="UniProtKB/Swiss-Prot:L0T5T4"
/protein_id="CCP43841.1"
/translation="SFAGAEAANASQLQSIARQVRGAVNAVAGQVTGNGGSGNSGTSA
AAANPNSDNTASIADRGTSAIMTTASATASSTGVDGGIAATYAVASQWDGGYVANYTI
TQFGRDFDDRLAVAIHFA"
gene 1215517..1215621
/gene="celA2a"
/locus_tag="Rv1089A"
CDS 1215517..1215621
/codon_start=1
/transl_table=11
/gene="celA2a"
/locus_tag="Rv1089A"
/product="Probable cellulase CelA2a
(endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl
cellulase)"
/note="Rv1089A, len: 34 aa. Probable celA2a, first part of
cellulase (endoglucanase), similar to N-terminus of
others. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1089A"
/db_xref="EnsemblGenomes-Tr:CCP43842"
/db_xref="UniProtKB/TrEMBL:Q79FS6"
/protein_id="CCP43842.1"
/translation="MNGAAPTNGAPLSYPSICEGVHWGHLVGGHQPAY"
gene 1215599..1216054
/gene="celA2b"
/locus_tag="Rv1090"
CDS 1215599..1216054
/codon_start=1
/transl_table=11
/gene="celA2b"
/locus_tag="Rv1090"
/product="Probable cellulase CelA2b
(endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl
cellulase)"
/note="Rv1090, (MTV017.43), len: 151 aa. Probable
celA2b,second part of cellulase (endoglucanase), similar
to C-terminus of others e.g. O08468 cellulase CEL2 from
Streptomyces halstedi (377 aa), FASTA scores: opt:
554,E(): 1.2e-30, (52.0% identity in 152 aa overlap); etc.
Gene appears to have been inactivated by frameshift
mutations but no errors could be found that would account
for this. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1090"
/db_xref="EnsemblGenomes-Tr:CCP43843"
/db_xref="GOA:O53438"
/db_xref="InterPro:IPR002594"
/db_xref="InterPro:IPR013319"
/db_xref="InterPro:IPR013320"
/db_xref="UniProtKB/TrEMBL:O53438"
/protein_id="CCP43843.1"
/translation="MGTNLPTEVGQILSAPTSIDYNYPTTGVWDASYDICLDSTPKTT
GVNQQEIMIWFNHQGSIQPVGSPVGNTTIEGKNFVVWDGSNGMNNAMAYVATEPIEVW
SFDVMSFVDHTATMEPITDSWYLTSIRAGLEPWSDGVGLGVDSFSAKVN"
gene 1216469..1219030
/gene="PE_PGRS22"
/locus_tag="Rv1091"
CDS 1216469..1219030
/codon_start=1
/transl_table=11
/gene="PE_PGRS22"
/locus_tag="Rv1091"
/product="PE-PGRS family protein PE_PGRS22"
/note="Rv1091, (MTV017.44), len: 853 aa. PE_PGRS22, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below).
Similar to Rv1087|AL021897|MTV017_39 Mycobacterium
tuberculosis H37Rv (767 aa), FASTA scores: opt: 2819, E():
0, (60.0% identity in 860 aa overlap). Predicted to be an
outer membrane protein (See Song et al., 2008). This
region is a possible MT-complex-specific genomic island
(See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1091"
/db_xref="EnsemblGenomes-Tr:CCP43844"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FS5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43844.1"
/translation="MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALLAAGA
DEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAAEAANVSAAQSTD
QRLLDLINGPTQALLGRPLIGDGANGGPGQDGGPGGLLYGNGGNGGTSTTAGVAGGNG
GAAGLIGNGGAGGGGGAGAAGGNGGAGGWLYGNGGAGGAGGTSVIPGVAGGNGGAGGS
AGLWGTGGAGGDGGNGRSGPVNVAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAA
FSINFTAGDGGAGGAGGSGGHALLWGAGGAGGNGGSGGTGGAGGSTAGAGGNGGAGGG
GGTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGGAGGDGGAGGAGGNAR
LWGVGGAGGAGGDGGAGGAGGKGGSGLSGNANGGAGGDSGRGGTGGAGGEGGAAGLLV
GTGGHGGDGGAGGAAVKGGDGGAAAGTGIAGAGGRGGAGGSGGSGGDGGGGAAGPAGW
LFGDGGAGGNGGAAAAGGAGGQAGGGGGNGGNGGNGGNGGNGGNGATGGWLYGNGGAG
GQGATAGAGGAGANGVSSTNGGGTGGNGGIGGTGGSGGAGGNAGLLGVGGAGGHGASG
GAGDRGGAGGTGFISSDGGAGGDGGDGGNGGAGGTGGLLFGAGGNGGPGGSGGAADIG
GNGGAGNGGGTDGNGGNGGSGGGAGSGGDGGGAGGNGAWLFGNGGAGGGGGKGGNGAG
GGLGGGSFGLPGLNGSGGDGGDGGNGAPGGVLYGNGGAGGQGSSGGIGGPGATGGAGG
KGGDGGDAQLIGDGGNGGNGGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP"
gene complement(1219248..1220186)
/gene="coaA"
/locus_tag="Rv1092c"
CDS complement(1219248..1220186)
/codon_start=1
/transl_table=11
/gene="coaA"
/locus_tag="Rv1092c"
/product="Probable pantothenate kinase CoaA (pantothenic
acid kinase)"
/note="Rv1092c, (MTV017.45c), len: 312 aa. Probable
coaA,pantothenate kinase, similar to many e.g.
P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores
:opt: 1079, E(): 0,(52.7% identity in 311 aa overlap).
Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae
(312 aa) (93.6% identity in 312 aa overlap). Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the pantothenate kinase family."
/db_xref="EnsemblGenomes-Gn:Rv1092c"
/db_xref="EnsemblGenomes-Tr:CCP43845"
/db_xref="GOA:P9WPA7"
/db_xref="InterPro:IPR004566"
/db_xref="InterPro:IPR006083"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:2GES"
/db_xref="PDB:2GET"
/db_xref="PDB:2GEU"
/db_xref="PDB:2GEV"
/db_xref="PDB:2ZS7"
/db_xref="PDB:2ZS8"
/db_xref="PDB:2ZS9"
/db_xref="PDB:2ZSA"
/db_xref="PDB:2ZSB"
/db_xref="PDB:2ZSD"
/db_xref="PDB:2ZSE"
/db_xref="PDB:2ZSF"
/db_xref="PDB:3AEZ"
/db_xref="PDB:3AF0"
/db_xref="PDB:3AF1"
/db_xref="PDB:3AF2"
/db_xref="PDB:3AF3"
/db_xref="PDB:3AF4"
/db_xref="PDB:3AVO"
/db_xref="PDB:3AVP"
/db_xref="PDB:3AVQ"
/db_xref="PDB:4BFS"
/db_xref="PDB:4BFT"
/db_xref="PDB:4BFU"
/db_xref="PDB:4BFV"
/db_xref="PDB:4BFW"
/db_xref="PDB:4BFX"
/db_xref="PDB:4BFY"
/db_xref="PDB:4BFZ"
/db_xref="PDB:5XLV"
/db_xref="PDB:5XLW"
/db_xref="PDB:5XMB"
/db_xref="UniProtKB/Swiss-Prot:P9WPA7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43845.1"
/translation="MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQI
DLLEVEEVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVG
KSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRRALMR
FVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNVLQTGPTLMVSDLF
DFSLYVDARIEDIEQWYVSRFLAMRTTAFADPESHFHHYAAFSDSQAVVAAREIWRTI
NRPNLVENILPTRPRATLVLRKDADHSINRLRLRKL"
gene complement(1220388..1220487)
/gene="MTS0858"
ncRNA complement(1220388..1220487)
/gene="MTS0858"
/product="Putative small regulatory RNA"
/note="MTS0858, putative small regulatory RNA (See Arnvig
et al., 2011), ends not mapped, ~100 bp band detected by
Northern blot."
/ncRNA_class="other"
gene 1220574..1221854
/gene="glyA1"
/gene_synonym="glyA"
/locus_tag="Rv1093"
CDS 1220574..1221854
/codon_start=1
/transl_table=11
/gene="glyA1"
/gene_synonym="glyA"
/locus_tag="Rv1093"
/product="Serine hydroxymethyltransferase 1 GlyA1"
/note="Rv1093, (MTV017.46), len: 426 aa. glyA1, serine
hydroxymethyltransferase 1, equivalent to
AL049491|MLCB1222_16 from Mycobacterium leprae (426
aa),FASTA score: (89.9 % identity in 426 aa overlap). Also
similar to many e.g. P34895|GLYA_HYPME hyphomicrobium
methylovorum (434 aa), FASTA scores: opt: 1492, E():
0,(56.8% identity in 419 aa overlap); etc. Belongs to the
ShmT family. Note that previously known as glyA."
/db_xref="EnsemblGenomes-Gn:Rv1093"
/db_xref="EnsemblGenomes-Tr:CCP43846"
/db_xref="GOA:P9WGI9"
/db_xref="InterPro:IPR001085"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR019798"
/db_xref="InterPro:IPR039429"
/db_xref="PDB:1LXB"
/db_xref="PDB:3H7F"
/db_xref="UniProtKB/Swiss-Prot:P9WGI9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43846.1"
/translation="MSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFVPRAVLQAQ
GSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAV
LHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATA
LEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHA
DVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAAT
PEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAE
DLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALAT
GSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR"
gene 1221959..1222786
/gene="desA2"
/locus_tag="Rv1094"
CDS 1221959..1222786
/codon_start=1
/transl_table=11
/gene="desA2"
/locus_tag="Rv1094"
/product="Possible acyl-[acyl-carrier protein] desaturase
DesA2 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase)"
/note="Rv1094, (MTV017.47), len: 275 aa. Possible
desA2,acyl-[acyl-carrier protein] desaturase (stearoyl-ACP
desaturase), equivalent to AL049491|MLCB1222_15 from
Mycobacterium leprae (275 aa), FASTA score: (78.1%
identity in 274 aa overlap). Also weakly similar to plant
stearoyl-acyl carrier protein desaturases, and very
similar to U49839|MTV043.16C|Rv0824c enzyme desA1 from
Mycobacterium tuberculosis (338 aa), FASTA scores: opt:
525, E(): 8.5e-30, (32.2% identity in 270 aa overlap); and
to U15182|MLU15182_32 acyl-carrier protein desaturase
precursor from Mycobacterium leprae (338 aa), FASTA
scores: opt: 506, E(): 1.9e-28, (34.1% identity in 261 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1094"
/db_xref="EnsemblGenomes-Tr:CCP43847"
/db_xref="GOA:P9WNZ5"
/db_xref="InterPro:IPR005067"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012348"
/db_xref="PDB:1ZA0"
/db_xref="UniProtKB/Swiss-Prot:P9WNZ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43847.1"
/translation="MAQKPVADALTLELEPVVEANMTRHLDTEDIWFAHDYVPFDQGE
NFAFLGGRDWDPSQSTLPRTITDACEILLILKDNLAGHHRELVEHFILEDWWGRWLGR
WTAEEHLHAIALREYLVVTREVDPVANEDVRVQHVMKGYRAEKYTQVETLVYMAFYER
CGAVFCRNLAAQIEEPILAGLIDRIARDEVRHEEFFANLVTHCLDYTRDETIAAIAAR
AADLDVLGADIEAYRDKLQNVADAGIFGKPQLRQLISDRITAWGLAGEPSLKQFVTG"
gene 1222997..1224298
/gene="phoH2"
/locus_tag="Rv1095"
CDS 1222997..1224298
/codon_start=1
/transl_table=11
/gene="phoH2"
/locus_tag="Rv1095"
/product="Probable PHOH-like protein PhoH2 (phosphate
starvation-inducible protein PSIH)"
/note="Rv1095, (MTV017.48), len: 433 aa. Probable
phoH2,phoH-like protein (phosphate starvation-induced
protein),probably ATP-binding protein. Equivalent to
AL049491 MLCB1222_14 Mycobacterium leprae (433 aa) (92.8%
identity in 432 aa overlap). Similar to many proteins
described as PhoH-like e.g. Z97025|BSZ97025_12 Bacillus
subtilis (442 aa), FASTA scores: opt: 605, E(): 0, (40.1%
identity in 444 aa overlap); or Mycobacterium tuberculosis
Rv2368c|O05830|PHOL_MYCTU Mycobacterium tuberculosis (352
aa), FASTA scores: opt: 390, E(): 4e-19, (31.5% identity
in 241 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop). Belongs to the PhoH family."
/db_xref="EnsemblGenomes-Gn:Rv1095"
/db_xref="EnsemblGenomes-Tr:CCP43848"
/db_xref="GOA:O53443"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR003714"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/TrEMBL:O53443"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43848.1"
/translation="MTDTRTYVLDTSVLLSDPWACSRFAEHDVVVPLVVISELEAKRH
HHELGWFARQALRLFDDLRLEHGRLDQPIPVGTQGGTLHVELNHTDPAVLPAGFRTDS
NDSRILSCAANLAAEGKRVTLVSKDIPLRVKAAAVGLAADEYHAQDVVVSGWSGMHEL
ETASADIDALFADGEIDLVEARDLPCHTGIRLLGGGSHALGRVNAHKRVQLVRGDREA
FGLRGRSAEQRVALDLLLDESVGIVSLGGKAGTGKSALALCAGLEAVLERRTHRKVVV
FRPLYAVGGQELGYLPGSESEKMGPWAQAVFDTLEGLASPAVLEEVLSRGMLEVLPLT
HIRGRSLHDSFVIVDEAQSLERNVLLTVLSRLGTGSRVVLTHDIAQRDNLRVGRHDGV
AAVIEKLKGHPLFAHITLLRSERSPIAALVTEMLEEITGPR"
gene 1224385..1225260
/locus_tag="Rv1096"
CDS 1224385..1225260
/codon_start=1
/transl_table=11
/locus_tag="Rv1096"
/product="Possible glycosyl hydrolase"
/note="Rv1096, (MTV017.49), len: 291 aa. Possible glycosyl
hydrolase, possibly deacetylase or esterase. Equivalent to
AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3%
identity in 289 aa overlap). Similar at the C-terminus to
enzymes involved in carbohydrate degradation including
Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog yjeA
from Bacillus subtilis (467 aa), FASTA scores: opt: 418,
E(): 2.6e-17, (38.6% identity in 184 aa overlap);
M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces
lividans (335 aa), FASTA scores: opt: 371, E():
1.1e-14,(31.6% identity in 237 aa overlap);
NP_345933.1|NC_003028 peptidoglycan N-acetylglucosamine
deacetylase a from Streptococcus pneumoniae (463 aa); etc.
Has possible N-terminal signal sequence with TMhelix at aa
13-31."
/db_xref="EnsemblGenomes-Gn:Rv1096"
/db_xref="EnsemblGenomes-Tr:CCP43849"
/db_xref="GOA:O53444"
/db_xref="InterPro:IPR002509"
/db_xref="InterPro:IPR011330"
/db_xref="UniProtKB/TrEMBL:O53444"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43849.1"
/translation="MPKRPDNQTWRYWRTVTGVVVAGAVLVVGGLSGRVTRAENLSCS
VIKCVALTFDDGPGPYTDRLLHILTDNDAKATFFLIGNKVAANPAGARRIADAGMEIG
SHTWEHPNMTTIPPEDIPGQFSRANDVIAAATGRTPTLYRPAGGLSNDAVRQAAAKVG
QAEILWDVIPFDWINDSNTAATRHMLMTQIKPGSVVLFHDTYSSTVDVVYQFIPVLKA
NGYRLVTVSELLGPRAPGSSYGSRENGPPVNELRDIPASEIPPLPNTSSPKPMPNFPI
TDIAGQNSGGPNNGA"
gene complement(1225263..1226144)
/locus_tag="Rv1097c"
CDS complement(1225263..1226144)
/codon_start=1
/transl_table=11
/locus_tag="Rv1097c"
/product="Probable membrane glycine and proline rich
protein"
/note="Rv1097c, (MTV017.50c), len: 293 aa. Probable
membrane Gly-, Pro-rich protein, similar to Mycobacterium
tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA
scores: opt: 219, E(): 0.023, (30.5% identity in 266 aa
overlap); and Rv2507. Contains potential membrane spanning
region (aa ~68-92)."
/db_xref="EnsemblGenomes-Gn:Rv1097c"
/db_xref="EnsemblGenomes-Tr:CCP43850"
/db_xref="GOA:O53445"
/db_xref="UniProtKB/TrEMBL:O53445"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43850.1"
/translation="MTVPPAGPYGNYPYGPNTYGQDPYWGGQPQGGSYPPAYPPQQYP
PGWPAGPYPPGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPA
TSAPTSQPFSQQTATGCTPNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNL
IDAVGVGHEVAGADQWMMQAEVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLG
PTKTSSITVDGVRAARVDADITIADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDAT
SRATVERVIEALKVNKS"
gene complement(1226141..1227565)
/gene="fum"
/locus_tag="Rv1098c"
CDS complement(1226141..1227565)
/codon_start=1
/transl_table=11
/gene="fum"
/locus_tag="Rv1098c"
/product="Probable fumarase Fum (fumarate hydratase)"
/note="Rv1098c, (MTV017.51c), len: 474 aa. Probable
fum,fumarase. Equivalent to AL049491|MLCB1222_11
Mycobacterium leprae (474 aa) (89.5 % identity in 467 aa
overlap). Similar to many e.g. P14408|FUMH_RAT fumarate
hydratase,mitochondrial precursor from Rattus norvegicus
(507 aa),FASTA scores: opt: 1427, E(): 0, (52.3% identity
in 461 aa overlap); and P05042|FUMC_ECOLI Fumarate
hydratase class II from Escherichia coli (467 aa), FASTA
scores: opt: 1355,E(): 0, (50.2% identity in 444 aa
overlap). Contains PS00163 Fumarate lyases signature."
/db_xref="EnsemblGenomes-Gn:Rv1098c"
/db_xref="EnsemblGenomes-Tr:CCP43851"
/db_xref="GOA:P9WN93"
/db_xref="InterPro:IPR000362"
/db_xref="InterPro:IPR005677"
/db_xref="InterPro:IPR008948"
/db_xref="InterPro:IPR018951"
/db_xref="InterPro:IPR020557"
/db_xref="InterPro:IPR022761"
/db_xref="InterPro:IPR024083"
/db_xref="PDB:3NO9"
/db_xref="PDB:4ADL"
/db_xref="PDB:4ADM"
/db_xref="PDB:4APA"
/db_xref="PDB:4APB"
/db_xref="PDB:5F91"
/db_xref="PDB:5F92"
/db_xref="UniProtKB/Swiss-Prot:P9WN93"
/inference="protein motif:PROSITE:PS00163"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43851.1"
/translation="MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGR
GLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQT
GSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLI
PALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACL
PRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVE
ASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVT
QVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLT
ANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLS
IEDLDRRLDVLAMAKAEQLDSDRL"
gene complement(1227596..1228684)
/gene="glpX"
/locus_tag="Rv1099c"
CDS complement(1227596..1228684)
/codon_start=1
/transl_table=11
/gene="glpX"
/locus_tag="Rv1099c"
/product="Fructose 1,6-bisphosphatase GlpX"
/note="Rv1099c, (MTV017.52c), len: 362 aa. glpX, class II
fructose 1,6-bisphosphatase (See Movahedzadeh et
al.,2004), highly similar to P44811|GLPX_HAEIN GLPX
protein homolog (believed to be involved in glycerol
metabolism) (333 aa), FASTA scores: opt: 763, E():0,
(46.2% identity in 327 aa overlap); and Q03224|YWJI_BACSU
hypothetical protein from Bacillus subtilis (321aa), FASTA
scores: opt: 1092,E(): 0, (52.1% identity in 313 aa
overlap). Equivalent to AL049491|MLCB1222_10 Mycobacterium
leprae (355 aa), (93.0% identity in 328 aa overlap).
N-terminus extended since first submission (previously 328
aa)."
/db_xref="EnsemblGenomes-Gn:Rv1099c"
/db_xref="EnsemblGenomes-Tr:CCP43852"
/db_xref="GOA:P9WN21"
/db_xref="InterPro:IPR004464"
/db_xref="UniProtKB/Swiss-Prot:P9WN21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43852.1"
/translation="MTAEGSGSSTAAVASHDPSHTRPSRREAPDRNLAMELVRVTEAG
AMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGN
GDGPECDFAVDPIDGTTLMSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAH
VLDITAPISENIRAVAKVKDLSVRDMTVCILDRPRHAQLIHDVRATGARIRLITDGDV
AGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAG
YDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMI
EAYHRLSKLNEYSAIDFTGDSSAVYPLP"
gene 1228683..1229384
/locus_tag="Rv1100"
CDS 1228683..1229384
/codon_start=1
/transl_table=11
/locus_tag="Rv1100"
/product="Conserved protein"
/note="Rv1100, (MTV017.53), len: 233 aa. Conserved
protein,slightly similar to Rv1906c|MTCY180.12
hypothetical protein from Mycobacterium tuberculosis (156
aa), FASTA scores: opt: 122, E(): 6.9, (27.4% identity in
135 aa overlap). Equivalent to AL049491|MLCB1222_9
Mycobacterium leprae (257 aa) (63.8% identity in 257 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1100"
/db_xref="EnsemblGenomes-Tr:CCP43853"
/db_xref="GOA:O53448"
/db_xref="InterPro:IPR025339"
/db_xref="UniProtKB/TrEMBL:O53448"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43853.1"
/translation="MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFW
SLAPLVVGCILLAGLVGMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPG
GWTPNSGGRGGIENGRADPATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSI
HPSMYPTGTVDVGGTRWVVYEGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFR
TLASATQSQPPLPAR"
gene complement(1229391..1230548)
/locus_tag="Rv1101c"
CDS complement(1229391..1230548)
/codon_start=1
/transl_table=11
/locus_tag="Rv1101c"
/product="Conserved membrane protein"
/note="Rv1101c, (MTV017.54c), len: 385 aa. Conserved
membrane protein, shows some similarity to other bacterial
proteins e.g. P77406|PERM_ECOLI putative permease perm
from Escherichia coli (353 aa), FASTA scores: opt: 287,
E(): 8.8e-12, (24.9% identity in 349 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1101c"
/db_xref="EnsemblGenomes-Tr:CCP43854"
/db_xref="GOA:P9WFM3"
/db_xref="InterPro:IPR002549"
/db_xref="UniProtKB/Swiss-Prot:P9WFM3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43854.1"
/translation="MNTEFTLTQKRALAILTLIALLFGAYFLRNYFVLIVVAAVGAYL
FTPLFKWFTKRFNTGLSAACTLLSALAAVVVPVGALVGLAIVQIARMVDSVADWVRTT
DLSTLGDKILQFVNGLFDRVPFLHITVTADALRKAMISVAQNVGEWLLHFLRDAAGSL
AGVITSAIIFVYVFVALLVNREKLRTLIGQLNPLGEDVTDLYLQKMGSMVRGTVNGQF
VIAACQGVAGAASIYIAGFHHGFFIFAIVLTALSIIPLGGGIVTIPFGIGMIFYGNIA
GGIFVLLWHLLVVTNIDNVLRPILVPRDARLNSALMLLSVFAGITMFGPWGIIIGPVL
MILIVTTIDVYLAVYKGVELEQFEAPPVRRRWLPRRGPATSRNAPPPSTAE"
gene complement(1230660..1230971)
/gene="mazF3"
/gene_synonym="mt6"
/locus_tag="Rv1102c"
CDS complement(1230660..1230971)
/codon_start=1
/transl_table=11
/gene="mazF3"
/gene_synonym="mt6"
/locus_tag="Rv1102c"
/product="Toxin MazF3"
/note="Rv1102c, (MTV017.55c), len: 103 aa. MazF3,
toxin,part of toxin-antitoxin (TA) operon with Rv1103c
(See Pandey and Gerdes, 2005; Zhu et al., 2006), similar
to Mycobacterium tuberculosis hypothetical protens e.g.
Rv1942c|MTCY9F9_22 (109 aa), FASTA scores: opt: 158, E():
3.6e-05, (33.3% identity in 93 aa overlap);
Rv0659c|MTCI376_17 (102aa), opt: 140, E(): 0.00072, (40.6%
identity in 69aa overlap); and Rv1495."
/db_xref="EnsemblGenomes-Gn:Rv1102c"
/db_xref="EnsemblGenomes-Tr:CCP43855"
/db_xref="GOA:P9WIH9"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="PDB:5CCA"
/db_xref="PDB:5UCT"
/db_xref="UniProtKB/Swiss-Prot:P9WIH9"
/protein_id="CCP43855.1"
/translation="MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLAT
EVPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYLLASQEPALAEAIGNAFDLDWVV
A"
gene complement(1230971..1231291)
/gene="mazE3"
/locus_tag="Rv1103c"
CDS complement(1230971..1231291)
/codon_start=1
/transl_table=11
/gene="mazE3"
/locus_tag="Rv1103c"
/product="Possible antitoxin MazE3"
/note="Rv1103c, (MTV017.56c), len: 106 aa. Possible
mazE3,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1102c (See Pandey and Gerdes, 2005; Zhu et al., 2006).
Note that Zhu et al., 2006 identifies a different amino
acid sequence as the possible antitoxin to Rv1102c.
Similar to part of Mycobacterium tuberculosis hypothetical
protein Rv2472|AL021246|MTV008_27 Mycobacterium
tuberculosis (97 aa), FASTA score: opt: 135, E(): 0.0091,
(45.8% identity in 72 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1103c"
/db_xref="EnsemblGenomes-Tr:CCP43856"
/db_xref="GOA:O53451"
/db_xref="UniProtKB/Swiss-Prot:O53451"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43856.1"
/translation="MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAF
IDDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTA
LDID"
gene 1231301..1231990
/locus_tag="Rv1104"
CDS 1231301..1231990
/codon_start=1
/transl_table=11
/locus_tag="Rv1104"
/product="Possible para-nitrobenzyl esterase (fragment)"
/note="Rv1104, (MTV017.57), len: 229 aa. Possible
para-nitrobenzyl esterase (fragment; possibly first part)
. Similar to the N-terminal domain of many e.g.
P37967|PNBA_BACSU Bacillus subtilis (489 aa), FASTA
scores: opt: 715, E(): 0, (53.4% identity in 191 aa
overlap). Gene may be inactivated as a frameshift is
required to obtain a product continuing in
MTV017.58|Rv1105."
/db_xref="EnsemblGenomes-Gn:Rv1104"
/db_xref="EnsemblGenomes-Tr:CCP43857"
/db_xref="InterPro:IPR002018"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53452"
/protein_id="CCP43857.1"
/translation="MVVDSCVAESRYGPVRGADDGRVKVWKGIRYAAPPLGDLRFRTP
EPPERWTEVADATTFGPACPQPAIPNMPLDLGASQSEDCWSLNIWAPADTEPGDGKPV
MVWLHGGAYILGSGSQPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRRFD
SNIGLRDVLAVLRWVADNIAVFGGDPEKVTLFGESARESSRPCSPPRRPRVCSRRRSP
RAHRRHRSTTR"
gene 1232311..1232826
/locus_tag="Rv1105"
CDS 1232311..1232826
/codon_start=1
/transl_table=11
/locus_tag="Rv1105"
/product="Possible para-nitrobenzyl esterase (fragment)"
/note="Rv1105, (MTV017.58), len: 171 aa. Possible
para-nitrobenzyl esterase (fragment; possibly second part)
. Similar to C-terminal domain of many e.g. P71048
para-nitrobenzyl esterase from Bacillus subtilis (489
aa),FASTA scores: opt: 248, E(): 2.7e-10, (32.3% identity
in 167 aa overlap). Gene may be inactivated as a
frameshift is required to obtain a product continuing from
MTV017.57|Rv1104. Start changed since first submission."
/db_xref="EnsemblGenomes-Gn:Rv1105"
/db_xref="EnsemblGenomes-Tr:CCP43858"
/db_xref="InterPro:IPR002018"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53453"
/protein_id="CCP43858.1"
/translation="MFTQIAAEQPDLQVPTEEQIGSAYSRWRRKARSLSMATDVGFRM
PSVWLAEGHSGVAPVYLYRFDYSTPLLKLLLVRAAHATELPYVWGNLGGSQDPALKLG
DAKAAIAVSRRVRTRWINFATRGKPTGPDGEPDWPCYEEAHRACLIIGRRDAVVHDVD
AHIRATWGSKW"
gene complement(1232844..1233956)
/locus_tag="Rv1106c"
CDS complement(1232844..1233956)
/codon_start=1
/transl_table=11
/locus_tag="Rv1106c"
/product="3-beta-hydroxysteroid dehydrogenase"
/note="Rv1106c, (MTV017.59c), len: 370 aa.
3-beta-hydroxysteroid dehydrogenase (see Yang et
al.,2007). Equivalent to AL049491|MLCB1222_7 Mycobacterium
leprae (376 aa) (75.5% identity in 375 aa overlap). Highly
similar to Q03704 NAD(P)-dependent cholesterol
dehydrogenase from Nocardia sp. (364 aa), FASTA scores:
opt: 1789, E(): 0, (74.5% identity in 361 aa overlap).
Also similar to U32426|MCU32426_1
3-beta-hydroxy-Delta5-steroid dehydrogenase from Molluscum
contagiosum virus (354 aa),FASTA scores: opt: 432, E():
1.7e-22, (34.6% identity in 347 aa overlap). Also similar
to series of Mycobacterium tuberculosis hypothetical
proteins described as sugar epimerases or dehydratases
e.g. Rv3634c, Rv3784, Rv3464,etc. The transcription of
this CDS seems to be activated specifically in host
granulomas (see Ramakrishnan et al.,2000)."
/db_xref="EnsemblGenomes-Gn:Rv1106c"
/db_xref="EnsemblGenomes-Tr:CCP43859"
/db_xref="GOA:P9WQP7"
/db_xref="InterPro:IPR002225"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WQP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43859.1"
/translation="MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSF
DRAPSLLPAHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTDEYRQR
SFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDETLPYTDRFNDLYTE
TKVVAERFVLAQNGVDGMLTCAIRPSGIWGNGDQTMFRKLFESVLKGHVKVLVGRKSA
RLDNSYVHNLIHGFILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWP
KMRISGPAVRWVMTGWQRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPL
FTTQQALTECLPYYVSLFEQMKNEARAEKTAATVKP"
gene complement(1233966..1234223)
/gene="xseB"
/locus_tag="Rv1107c"
CDS complement(1233966..1234223)
/codon_start=1
/transl_table=11
/gene="xseB"
/locus_tag="Rv1107c"
/product="Probable exodeoxyribonuclease VII (small
subunit) XseB (exonuclease VII small subunit)"
/note="Rv1107c, (MTV017.60c), len: 85 aa. Probable
xseB,exonuclease VII small subunit (see citation below).
Equivalent to AL049491|MLCB1222_6 Mycobacterium leprae (87
aa) (77.9% identity in 68 aa overlap). Similar to
P43914|EX7S_HAEIN exodeoxyribonuclease small subunit from
H. influenzae (84 aa), FASTA scores: opt: 126, E():
0.006,(37.3% identity in 67 aa overlap); and
P22938|EX7S_ECOLI exodeoxyribonuclease small subunit from
Escherichia coli (79 aa), FASTA scores: opt: 125, E():
0.0067, (39.7% identity in 58 aa overlap). Belongs to the
XseB family."
/db_xref="EnsemblGenomes-Gn:Rv1107c"
/db_xref="EnsemblGenomes-Tr:CCP43860"
/db_xref="GOA:P9WF29"
/db_xref="InterPro:IPR003761"
/db_xref="InterPro:IPR037004"
/db_xref="UniProtKB/Swiss-Prot:P9WF29"
/protein_id="CCP43860.1"
/translation="MVCDPNGDDTGRTHATVPVSQLGYEACRDELMEVVRLLEQGGLD
LDASLRLWERGEQLAKRCEEHLAGARQRVSDVLAGDEAQNG"
gene complement(1234213..1235460)
/gene="xseA"
/locus_tag="Rv1108c"
CDS complement(1234213..1235460)
/codon_start=1
/transl_table=11
/gene="xseA"
/locus_tag="Rv1108c"
/product="Probable exodeoxyribonuclease VII (large
subunit) XseA (exonuclease VII large subunit)"
/note="Rv1108c, (MTV017.61c), len: 415 aa. Probable
xseA,exodeoxyribonuclease VII large subunit (see Mizrahi &
Andersen 1998). Equivalent to AL049491|MLCB1222_5
Mycobacterium leprae (428 aa) (81.5% identity in 411 aa
overlap). Similar to many e.g. P04994|EX7L_ECOLI
exodeoxyribonuclease large subunit from Escherichia coli
(456 aa), FASTA scores: opt: 581, E(): 1.6 e-30, (30.8%
identity in 425 aa overlap); also similar to the
exodeoxyribonuclease in Bacillus subtilis, H. influenzae
and H. pylori. Belongs to the XseA family."
/db_xref="EnsemblGenomes-Gn:Rv1108c"
/db_xref="EnsemblGenomes-Tr:CCP43861"
/db_xref="GOA:P9WF31"
/db_xref="InterPro:IPR003753"
/db_xref="InterPro:IPR020579"
/db_xref="InterPro:IPR025824"
/db_xref="UniProtKB/Swiss-Prot:P9WF31"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43861.1"
/translation="MTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDA
KTVFMVLRDPAADMSLTVTCSRDLVLSAPVKLAEGVQVVVCGKPSFYTGRGTFSLRLS
EIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTT
VASARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPF
SDETLCRAIAACRTPVVSAVGHEPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLI
DDLRRRSAQALRNWVSREQRAVAQLRSRPVLADPMTMVSVRAEEVHRARSTLRRNLTL
MVAAETERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEG
TKLRVRVADGALAAVSEGQTNGL"
gene complement(1235457..1236095)
/locus_tag="Rv1109c"
CDS complement(1235457..1236095)
/codon_start=1
/transl_table=11
/locus_tag="Rv1109c"
/product="Conserved protein"
/note="Rv1109c, (MTV017.62c), len: 212 aa. Conserved
protein. Equivalent to AL049491|MLCB1222_4 hypothetical
protein from Mycobacterium leprae (205 aa) (68.1% identity
in 213 aa overlap). A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1109c"
/db_xref="EnsemblGenomes-Tr:CCP43862"
/db_xref="GOA:P9WM59"
/db_xref="UniProtKB/Swiss-Prot:P9WM59"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43862.1"
/translation="MATAPYGVRLLVGAATVAVEETMKLPRTILMYPMTLASQAAHVV
MRFQQGLAELVIKGDNTLETLFPPKDEKPEWATFDEDLPDALEGTSIPLLGLSDASEA
KNDDRRSDGRFALYSVSDTPETTTASRSADRSTNPKTAKHPKSAAKPTVPTPAVAAEL
DYPALTLAQLRARLHTLDVPELEALLAYEQATKARAPFQTLLANRITRATAK"
gene 1236185..1237192
/gene="lytB2"
/locus_tag="Rv1110"
CDS 1236185..1237192
/codon_start=1
/transl_table=11
/gene="lytB2"
/locus_tag="Rv1110"
/product="Probable LYTB-related protein LytB2"
/note="Rv1110, (MTV017.63), len: 335 aa. Probable
lytB2,LytB-related protein, equivalent to
AL049491|MLCB1222_3 from Mycobacterium leprae (335 aa),
FASTA score: (82.9% identity in 333 aa overlap). Also
similar to LytB proteins from many bacteria (appears to
have N-terminal extension) e.g.
P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB protein from
Escherichia coli strains K12 and O157:H7 (316 aa),FASTA
scores: opt: 1041, E():0, (52.4% identity in 309 aa
overlap); etc. Also very similar to another LytB-related
protein from Mycobacterium tuberculosis:
LytB1|Rv3382c|MTV004.40c (329 aa), FASTA scores: opt:
975,E(): 0, (51.3% identity in 312 aa overlap). Belongs to
the LytB family."
/db_xref="EnsemblGenomes-Gn:Rv1110"
/db_xref="EnsemblGenomes-Tr:CCP43863"
/db_xref="GOA:P9WKG1"
/db_xref="InterPro:IPR003451"
/db_xref="UniProtKB/Swiss-Prot:P9WKG1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43863.1"
/translation="MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAV
ETVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVA
PTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAP
DHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDI
CYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDS
AWLDGVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSP
R"
gene complement(1237209..1238192)
/locus_tag="Rv1111c"
CDS complement(1237209..1238192)
/codon_start=1
/transl_table=11
/locus_tag="Rv1111c"
/product="Conserved hypothetical protein"
/note="Rv1111c, (MTV017.64c), len: 327 aa. Conserved
hypothetical protein, N-terminal domain is
hydrophobic,C-terminal half is very rich in Arg.
Equivalent to AL049491|MLCB1222_2 hypothetical protein
from Mycobacterium leprae (379 aa) (46.0% identity in 374
aa overlap). Start changed since first submission. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv1111c"
/db_xref="EnsemblGenomes-Tr:CCP43864"
/db_xref="GOA:O86351"
/db_xref="UniProtKB/TrEMBL:O86351"
/protein_id="CCP43864.1"
/translation="MSAQRARSAVQASHRSIHPHIPGVPWWAAILIAVTATAIGYAID
AGSGHKALTLVFTGCYIAGCVGAVLAVRQSDLFTALVQPPLILFCAVPGAYWLFHGGT
IGKFKDLLINCGYSLIERFPLMLGTAAGVLLIGLVRWYLGTALFDSIARKLSSLMTGD
SDDDGGRRSAQRPARTRSRHARPPSEDNREPIAERRSRRRPRPQNDPHPRRNAHERPA
PRSSRFDSYRSYQPSEPSGPAEPVNRYERRGARYQPYARYEPTYEPQRRRARPSEPTN
PTHHPISQVRYRGSATRDARRDNYREEQRFDRRDRSRAPRRPPAESWEYDV"
gene 1238255..1239328
/locus_tag="Rv1112"
CDS 1238255..1239328
/codon_start=1
/transl_table=11
/locus_tag="Rv1112"
/product="Probable GTP binding protein"
/note="Rv1112, (MTCY22G8.01-MTV017.65), len: 357 aa.
Probable GTP binding protein, similar to YCHF_HAEIN|P44681
probable gtp-binding protein (362 aa), FASTA scores: opt:
1189, E(): 0, (52.7% identity in 357 aa overlap).
Equivalent to AL049491|MLCB1222_1 hypothetical protein
from Mycobacterium leprae (356 aa) (85.9% identity in 354
aa overlap0. Contains PS00017 ATP/GTP-binding site motif A
(P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv1112"
/db_xref="EnsemblGenomes-Tr:CCP43865"
/db_xref="GOA:O53459"
/db_xref="InterPro:IPR004396"
/db_xref="InterPro:IPR006073"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR012676"
/db_xref="InterPro:IPR013029"
/db_xref="InterPro:IPR023192"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031167"
/db_xref="InterPro:IPR041706"
/db_xref="UniProtKB/TrEMBL:O53459"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43865.1"
/translation="MSLSLGIVGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVV
SLPDPRLDKLAELFGSQRVVPAPVTFVDIAGLVKGASEGAGLGNKFLAHIRECDAICQ
VVRVFVDDDVTHVTGRVDPQSDIEVVETELILADLQTLERATGRLEKEARTNKARKPV
YDAALRAQQVLDAGKTLFAAGVDAAALRELNLLTTKPFLYVFNADEAVLTDPARVGEL
RALVAPADAVFLDAAIESELTELDDESAAELLESIGQSERGLDALARAGFHTLKLQTF
LTAGPKEARAWTIHQGDTAPKAAGVIHSDFEKGFIKAEIVSYDDLVAAGSMAAAKAAG
KVRIEGKDYVMADGDVVEFRFNV"
gene 1239416..1239613
/gene="vapB32"
/locus_tag="Rv1113"
CDS 1239416..1239613
/codon_start=1
/transl_table=11
/gene="vapB32"
/locus_tag="Rv1113"
/product="Possible antitoxin VapB32"
/note="Rv1113, (MTCY22G8.02), len: 65 aa. Possible
vapB32,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1114,see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis e.g. Rv2758c|AL00896
7|MTV002.23 (88 aa) FASTA scores: opt: 97, E(): 0.86,
(33.3% identity in 69 aa overlap). Part of family
including Rv2871, Rv1241, Rv2132,Rv3321c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1113"
/db_xref="EnsemblGenomes-Tr:CCP43866"
/db_xref="GOA:P9WJ33"
/db_xref="InterPro:IPR019239"
/db_xref="UniProtKB/Swiss-Prot:P9WJ33"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43866.1"
/translation="MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRL
AALGGTDPQATAAPRRRTSPR"
gene 1239610..1239984
/gene="vapC32"
/locus_tag="Rv1114"
CDS 1239610..1239984
/codon_start=1
/transl_table=11
/gene="vapC32"
/locus_tag="Rv1114"
/product="Possible toxin VapC32. Contains PIN domain."
/note="Rv1114, (MTCY22G8.03), len: 124 aa. Possible
vapC32,toxin, part of toxin-antitoxin (TA) operon with
Rv1113,contains PIN domain, see Arcus et al. 2005. Similar
to others in Mycobacterium tuberculosis e.g. Rv1561 and
Rv2010."
/db_xref="EnsemblGenomes-Gn:Rv1114"
/db_xref="EnsemblGenomes-Tr:CCP43867"
/db_xref="GOA:P9WF73"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF73"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43867.1"
/translation="MILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSI
KQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGRGLGAVDANLLGSVALVGGARLW
TRDKRLKAACAESGVALAEEVS"
gene 1240187..1240885
/locus_tag="Rv1115"
CDS 1240187..1240885
/codon_start=1
/transl_table=11
/locus_tag="Rv1115"
/product="Possible exported protein"
/note="Rv1115, (MTCY22G8.04), len: 232 aa. Possible
exported protein, contains possible N-terminal signal
sequence."
/db_xref="EnsemblGenomes-Gn:Rv1115"
/db_xref="EnsemblGenomes-Tr:CCP43868"
/db_xref="GOA:O06567"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/TrEMBL:O06567"
/protein_id="CCP43868.1"
/translation="MISTTRIDFLWILSVAFASMIALATLLTLINQVVGTPYIPGGDS
PAGTDCSELASWVSNAATARPVFGDRFNTGNEEAALAARGFQQGTAPNALVIGWNGHH
TAVTLPDGTPVSSGEGGGVRVGGGGAYQPKFTHHMYLPMDVDAGEDQPPAPDEPVTAV
DDVEPEMPAPCPTQRPPVTPRHNLCNKLRTMPGALSAALAAAAPVWPAPISGCRGFST
SLLAKRNHPVIVGK"
gene 1241003..1241188
/locus_tag="Rv1116"
CDS 1241003..1241188
/codon_start=1
/transl_table=11
/locus_tag="Rv1116"
/product="Hypothetical protein"
/note="Rv1116, (MTCY22G8.05), len: 61 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1116"
/db_xref="EnsemblGenomes-Tr:CCP43869"
/db_xref="UniProtKB/TrEMBL:O06568"
/protein_id="CCP43869.1"
/translation="MCSRMADEPRLEAGAHPFEEGRDKAPELRATQMDHVRFTEGRRE
RNRDRLERSQQFRQPGR"
gene complement(1241115..1241390)
/locus_tag="Rv1116A"
CDS complement(1241115..1241390)
/codon_start=1
/transl_table=11
/locus_tag="Rv1116A"
/product="Conserved hypothetical protein (fragment)"
/note="Rv1116A, len: 91 aa. Conserved hypothetical protein
(possibly gene fragment), similar to C-terminal part of
Rv1646|Z85982_9 from Mycobacterium tuberculosis (310
aa),FASTA scores: opt: 301, E(): 9.3e-13, (68.05% identity
in 72 aa overlap). Also overlaps gene on other strand,
Rv1116,at 3'-end."
/db_xref="EnsemblGenomes-Gn:Rv1116A"
/db_xref="EnsemblGenomes-Tr:CCP43870"
/db_xref="UniProtKB/TrEMBL:L7N6A9"
/protein_id="CCP43870.1"
/translation="MGALGTVRGLQDSNTAFVGALHSGNLLGATGAVLQAPGNAVNGF
LFGQTSISQSIDVSPEYGYELVAVSDPVGGTAGSARAGHGYVHADLR"
gene 1241633..1241956
/locus_tag="Rv1117"
CDS 1241633..1241956
/codon_start=1
/transl_table=11
/locus_tag="Rv1117"
/product="Conserved protein"
/note="Rv1117, (MTCY22G8.06), len: 107 aa. Conserved
protein, some similarity to P94425|D50453 hypothetical
protein from Bacillus subtilis (95 aa), fasta scores: opt:
128, E(): 5.1e-06, (28.3% identity in 92 aa overlap); and
AL117322|SCF1.02 Streptomyces coelicolor (109 aa), FASTA
scores: opt: 437, E(): 1.6e-25, (57.5% identity in 106 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1117"
/db_xref="EnsemblGenomes-Tr:CCP43871"
/db_xref="InterPro:IPR007138"
/db_xref="InterPro:IPR011008"
/db_xref="UniProtKB/TrEMBL:O06569"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43871.1"
/translation="MIFIVVKFETKPEWTERWPDLVASFTAATRAEEGNLWFEWSRSL
DDPAEYVLVESFRDGEAGGVHVNSDHFRQAMRELPKALASTPKIISQTIDATGWSAMG
EMTVG"
gene complement(1241971..1242831)
/locus_tag="Rv1118c"
CDS complement(1241971..1242831)
/codon_start=1
/transl_table=11
/locus_tag="Rv1118c"
/product="Conserved protein"
/note="Rv1118c, (MTCY22G8.07c), len: 286 aa. Conserved
protein, similar to pseudogene ML0942 in Mycobacterium
leprae."
/db_xref="EnsemblGenomes-Gn:Rv1118c"
/db_xref="EnsemblGenomes-Tr:CCP43872"
/db_xref="GOA:O06570"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/TrEMBL:O06570"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43872.1"
/translation="MQSGPHLVGRVGTSFPLIARHQGATRDDAGDTGQPDPLPHVAHP
DRLYPPMVHGVDPSTLALDRALNETRTGDLWLFRGRSRPDRAIQTLTNAPVNHVGMTV
AIDDLPPLIWHAELGDKLLDVWTGTNHRGVQLNDARQVVQQWAGRYRQRCWLRQLTPH
ANRDQEDKLLRVIARMNGTPFPTTARLTGRWLRGRLPTLNDWLRGIPVLDRKVREQTQ
RRKQQQRTMGLATAYCAETVAITYEEMGLLVTDKDAHWFDPGKFWSGDSLPLAPGYRL
GHEIAVDVGG"
gene complement(1242864..1243013)
/locus_tag="Rv1119c"
CDS complement(1242864..1243013)
/codon_start=1
/transl_table=11
/locus_tag="Rv1119c"
/product="Hypothetical protein"
/note="Rv1119c, (MTCY22G8.08c), len: 49 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1119c"
/db_xref="EnsemblGenomes-Tr:CCP43873"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/TrEMBL:O06571"
/protein_id="CCP43873.1"
/translation="MTARVAGQAVGGQILVGEPVHDAVSDCADIRFGSYRLFSLDAAP
GPDLD"
gene complement(1243010..1243504)
/locus_tag="Rv1120c"
CDS complement(1243010..1243504)
/codon_start=1
/transl_table=11
/locus_tag="Rv1120c"
/product="Conserved hypothetical protein"
/note="Rv1120c, (MTCY22G8.09c), len: 164 aa. Conserved
hypothetical protein, some similarity at C-terminus to
Mycobacterium tuberculosis hypothetical proteins e.g.
Rv1890c|MTCY180.28 (462 aa), FASTA scores: opt: 187, E():
2.2e-05, (36.6% identity in 93 aa overlap) and
Rv2488c|YZ19_MYCTU|Q10551 (285 aa), FASTA scores: opt:
156,E(): 0.00074, (32.7% identity in 107 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1120c"
/db_xref="EnsemblGenomes-Tr:CCP43874"
/db_xref="GOA:O06572"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/TrEMBL:O06572"
/protein_id="CCP43874.1"
/translation="MLSGGREAVKTVWQTANLVRKEGFGAAVRSSIEDPADWAEVERP
DLARVTPDGRVVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMVTS
QGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWGARCGTVTICSA
ATSQ"
gene 1243707..1245107
/gene="zwf1"
/gene_synonym="zwf"
/locus_tag="Rv1121"
CDS 1243707..1245107
/codon_start=1
/transl_table=11
/gene="zwf1"
/gene_synonym="zwf"
/locus_tag="Rv1121"
/product="Probable glucose-6-phosphate 1-dehydrogenase
Zwf1 (G6PD)"
/note="Rv1121, (MTCY22G8.10), len: 466 aa. Probable
zwf1,glucose-6-phosphate 1-dehydrogenase, highly similar
to many e.g. G6PD_E COLI|P22992 Escherichia coli (491 aa),
FASTA scores: opt: 642, E(): 0, (35.8% identity in 478 aa
overlap). Mycobacterium tuberculosis has two genes for
ZWF,this one is highly divergent. Belongs to the
glucose-6-phosphate dehydrogenase family. Note that
previously known as zwf. Nucleotide position 1244700 in
the genome sequence has been corrected, T:C resulting in
L332L."
/db_xref="EnsemblGenomes-Gn:Rv1121"
/db_xref="EnsemblGenomes-Tr:CCP43875"
/db_xref="GOA:P9WN71"
/db_xref="InterPro:IPR001282"
/db_xref="InterPro:IPR019796"
/db_xref="InterPro:IPR022674"
/db_xref="InterPro:IPR022675"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN71"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43875.1"
/translation="MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPIL
GVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELI
GSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAV
LGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGK
FYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRG
QYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRR
VPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIR
PYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLR
GHRGWQSPWLPRGTDA"
gene 1245129..1246151
/gene="gnd2"
/locus_tag="Rv1122"
CDS 1245129..1246151
/codon_start=1
/transl_table=11
/gene="gnd2"
/locus_tag="Rv1122"
/product="Probable 6-phosphogluconate
dehydrogenase,decarboxylating Gnd2"
/note="Rv1122, (MTCY22G8.11), len: 340 aa. Probable
gnd2,6-phosphogluconate dehydrogenase, decarboxylating,
highly similar to Q53917 6-phosphogluconate dehydrogenase
from Streptomyces coelicolor (291 aa), fasta scores: opt:
431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also
similar to Rv1844c|MTCY359.29|gnd1 probable
6-phosphogluconate dehydrogenase from Mycobacterium
tuberculosis (485 aa), FASTA score: (33.0% identity in 351
aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most
similar to gnd's from Gram negative organisms, while gnd2
is most similar to gnd's from Gram positive organisms.
Belongs to the 6-phosphogluconate dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv1122"
/db_xref="EnsemblGenomes-Tr:CCP43876"
/db_xref="GOA:O06574"
/db_xref="InterPro:IPR004849"
/db_xref="InterPro:IPR006114"
/db_xref="InterPro:IPR006115"
/db_xref="InterPro:IPR006183"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O06574"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43876.1"
/translation="MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDR
TTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDD
LRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAA
PRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGT
RVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEF
SGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFANKALSAMRKQFGGH
AEKPAN"
gene complement(1246144..1247052)
/gene="bpoB"
/locus_tag="Rv1123c"
CDS complement(1246144..1247052)
/codon_start=1
/transl_table=11
/gene="bpoB"
/locus_tag="Rv1123c"
/product="Possible peroxidase BpoB (non-haem peroxidase)"
/note="Rv1123c, (MTCY22G8.12c), len: 302 aa. Possible
bpoB,peroxidase (non-haem peroxidase), with some
similarity to a range of enzymes from several organisms
including: DEH1_MORSP|Q01398 haloacetate dehalogenase from
Moraxella sp. (294 aa), FASTA scores: opt: 201, E():
2.1e-06, (35.8% identity in 134 aa overlap); and
BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 from
Streptomyces aureofaciens (274 aa), FASTA scores: opt:
187, E(): 1.6e-05, (23.1% identity in 281 aa overlap).
Similar to several other Mycobacterium tuberculosis
proteins, probable epoxide hydrolases and non-heme
bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c,Rv3171c,
etc. Contains PS00216 Sugar transport proteins signature
1."
/db_xref="EnsemblGenomes-Gn:Rv1123c"
/db_xref="EnsemblGenomes-Tr:CCP43877"
/db_xref="GOA:O06575"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O06575"
/inference="protein motif:PROSITE:PS00216"
/protein_id="CCP43877.1"
/translation="MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGA
AAADRPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDRAPGADYAVET
PTTDVLHVVEAIGRRVVVVEASMGGLTGILVAERAGPQTVNGLVLVDVVPRYEKEGNA
RIRDFMLGNIDGFGSLEEAADAVAEYLPHRDKPRSPEGLKRNLRLRDGRWHWHWDPAM
MTAPGHDPQLRTENFERAAMGLTIPVLLIRGKLSDVVSSDGARDFLAKVPNAEFVELS
NAGRTAAGDDNDAFTDVVVDFVRRLS"
gene 1247127..1248077
/gene="ephC"
/locus_tag="Rv1124"
CDS 1247127..1248077
/codon_start=1
/transl_table=11
/gene="ephC"
/locus_tag="Rv1124"
/product="Probable epoxide hydrolase EphC (epoxide
hydratase)"
/note="Rv1124, (MTCY22G8.13), len: 316 aa. Probable
ephC,epoxide hydrolase (see citation below), similar to
Q42566 epoxide hydrolase from Arabidopsis thaliana (321
aa), FASTA scores: opt: 298, E(): 8.2e-13, (27.6% identity
in 333 aa overlap). Similar to other M. tuberculosis
epoxide hydrolases and non-heme bromoperoxidases e.g.
Rv1938,Rv3617, Rv3670, Rv3473c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1124"
/db_xref="EnsemblGenomes-Tr:CCP43878"
/db_xref="GOA:O06576"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O06576"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43878.1"
/translation="MRAGRGERESTWRTTMAEPHWIDVKGPNGDLKALTWGPAGAPVA
LCLHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGYAPSSIPADGSYHVGALMHDALRV
RSAAGGTERDVIIGHDWGAIAATGLAAMPDSPFAKAVIMSVPPSAAFRPLGRVPERGR
LLRELPHQLLRSWYILYFQLPWLPERSASWVVPLLWRRWSPGYHAEEDLRHVDAAIGT
PEGRRAALGPYRATMRNTRAPADYADLNRLWTEAPKLPVLYLHGHDDGCATSAFTHWT
ARVLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG"
gene 1248082..1249326
/locus_tag="Rv1125"
CDS 1248082..1249326
/codon_start=1
/transl_table=11
/locus_tag="Rv1125"
/product="Conserved hypothetical protein"
/note="Rv1125, (MTCY22G8.14), len: 414 aa. Conserved
hypothetical protein. Similar to AL133278|SCM11.13
hypothetical protein from Streptomyces coelicolor (446
aa),FASTA scores: opt: 182, E(): 0.0005, (28.1% identity
in 437 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1125"
/db_xref="EnsemblGenomes-Tr:CCP43879"
/db_xref="GOA:O06577"
/db_xref="InterPro:IPR009721"
/db_xref="UniProtKB/TrEMBL:O06577"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43879.1"
/translation="MAGHRMAAVDAQFYWMSAKVPNDQFLLYAFDGEPTDLERAVAQV
YRRARGCPGLGMRVQDRGALAYPQWVPTPVQRDQLVCHDLADRSWQGCLAAVVGLASK
QLDMRRMPWRLHVFTPVHDVPGVSGLGTVAVMQFAHALGDGARASAMAAWLFGRPAAV
PEIARSRAGFLPWRAAHAARAHLRLVRDTNAGLVAPGVGSRPPLSTNARPEGVRAVRT
LLRRRSQLAGPTVTVTVLAAVSTGLLGLLGGDVDTLGAEVPMAKPGVPRSYNHFGNVV
VGLYPRLEPDERVRRIATDLANARRRFEHPAMLSADRAFAAVPAALLRWGVSQFDAEV
RPVRVAGNTVVSSVYRGAADLSFGDAPVVLTAGYPALSPAMGLTHGVHGIGDTVAISV
HAAESAVSDIDAYMRLLDAALQ"
gene complement(1249330..1249935)
/locus_tag="Rv1126c"
CDS complement(1249330..1249935)
/codon_start=1
/transl_table=11
/locus_tag="Rv1126c"
/product="Conserved protein"
/note="Rv1126c, (MTCY22G8.15c), len: 201 aa. Conserved
protein, similar in N-terminus to O05567|MLCB33.17
hypothetical protein from Mycobacterium leprae (141
aa),FASTA scores: opt: 332, E(): 1.4e-23, (58.4% identity
in 101 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1126c"
/db_xref="EnsemblGenomes-Tr:CCP43880"
/db_xref="GOA:O06578"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O06578"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43880.1"
/translation="MSELTVLQAVRLKGRVITTDLAQTLGEDLADVAATVDRLTAAGL
LVDATPLRISPSGRMRLDDLLAEERNRADSTVLAAAYRDFRSVNADFKRLVTDWQLKG
EKPNTHDDAEYDAAVLSRLDGVHRRVGPIIGTVAMQLPRLSRYPVKLRAALDKVKAGD
IAWLTRPLIDSYHTVWFELHEELIQAVGLTRDEAAKSGDAQ"
gene complement(1249932..1251404)
/gene="ppdK"
/locus_tag="Rv1127c"
CDS complement(1249932..1251404)
/codon_start=1
/transl_table=11
/gene="ppdK"
/locus_tag="Rv1127c"
/product="Probable pyruvate, phosphate dikinase PpdK"
/note="Rv1127c, (MTCY22G8.16c), len: 490 aa. Probable
ppdK,Pyruvate, phosphate dikinase. Equivalent (but
shorter) to Z94723|MLCB33_16 ppdK from Mycobacterium
leprae (601 aa) (71.8% identity in 478 aa overlap). Highly
similar to N-terminus of PODK_CLOSY|P22983 pyruvate,
phosphate dikinase from Clostridium symbiosum (873 aa),
FASTA scores: opt: 786, E(): 0, (37.4% identity in 514 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1127c"
/db_xref="EnsemblGenomes-Tr:CCP43881"
/db_xref="GOA:O06579"
/db_xref="InterPro:IPR002192"
/db_xref="InterPro:IPR008279"
/db_xref="InterPro:IPR010121"
/db_xref="InterPro:IPR036637"
/db_xref="UniProtKB/TrEMBL:O06579"
/protein_id="CCP43881.1"
/translation="MTRITRANGCPDGTLENAVVALDGGANYPREILGNKGHGIDMMR
RHHLPVPPAFCITTEVGVRYLAAPGSTIAAIWDDVLDRMSWLETETSCTFGRGPNPLL
VSVRSGATQSMPGMMDTILDVGMTDAVERVLARPGAADFAHDTRRRFTSMYRRIVGSA
GPITDDPYAQLRASIEAVFASWNSPRAVAYRDHHGLDDQGGTAVVVQAMVFGNLTANS
GAGVLSSRNPITGANEPFGEWLPGGQGDDVVSGLVAVAPITALRDQQPAVYDQLMAAA
RSLERMAGDVQEIEFTVEDSQLWLLQTRGAERSAQAAVRLALQLHHEGLIDDTETLRR
VTPTHIETLLRPSLQTETRLAAPLLAKGLPACPGVVSGTAYTEVDEALDAADRGEPVI
LVRDHTRPEDVMGMLAAQGIVTEVGGAASHAAVVSRELGRVAVVGCGPGVAAALAGKE
ITVDGYEGEVRQGVLALSAWSESDTPELRELADIAQRISS"
gene complement(1251617..1252972)
/locus_tag="Rv1128c"
CDS complement(1251617..1252972)
/codon_start=1
/transl_table=11
/locus_tag="Rv1128c"
/product="Conserved hypothetical protein"
/note="Rv1128c, (MTCY22G8.17c), len: 451 aa. Conserved
hypothetical protein, in REP13E12 degenerate repeat,
highly similar to several Mycobacterium tuberculosis
proteins in REP13E12 repeats e.g. Rv1148c, Rv1945, Rv3467,
etc."
/db_xref="EnsemblGenomes-Gn:Rv1128c"
/db_xref="EnsemblGenomes-Tr:CCP43882"
/db_xref="GOA:P9WM57"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P9WM57"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43882.1"
/translation="MCSTREEITEAFASLATALSRVLGLTFDALTTPERLALLEHCET
ARRQLPSVEHTLINQIGEQSTEEELGGKLGLTLADRLRITRSEAKRRVAEAADLGQRR
ALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPSWVDLKTLEKAERDLAKQA
TQYRPDQLAKLAARIMDCLNPDGDYTDEDRARRRGLTLGKQDVDGMSRLSGYVTPELR
ATIEAVWAKLAAPGMCNPEQKAPCVNGAPSKEQARRDTRSCPQRNHDALNAELRSLLT
SGNLGQHNGLPASIIVTTTLKDLEAAAGAGLTGGGTILPISDVIRLARHANHYLAIFD
RGKALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVTPYAQCRNTDVN
DLTLGCGGHHPLAERGWTTRKNAHGDTEWLPPPHLDHGQPRVNTFHHPEKLLADDEGD
P"
repeat_region 1251621..1252945
/note="REP-3, len: 1325 nt. REP22G8, member of REP13E12
family."
gene complement(1253074..1254534)
/locus_tag="Rv1129c"
CDS complement(1253074..1254534)
/codon_start=1
/transl_table=11
/locus_tag="Rv1129c"
/product="Probable transcriptional regulator protein"
/note="Rv1129c, (MTCY22G8.18c), len: 486 aa. Possible
transcriptional regulator protein, similar to
Rv0465c|MTV038.09c Mycobacterium tuberculosis (474
aa),FASTA scores: E(): 0, (47.4% identity in 468 aa
overlap). Helix turn helix motif present from aa 32-53."
/db_xref="EnsemblGenomes-Gn:Rv1129c"
/db_xref="EnsemblGenomes-Tr:CCP43883"
/db_xref="GOA:O06581"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010359"
/db_xref="InterPro:IPR010982"
/db_xref="InterPro:IPR018653"
/db_xref="InterPro:IPR026281"
/db_xref="PDB:6CYJ"
/db_xref="PDB:6CYY"
/db_xref="PDB:6CZ6"
/db_xref="PDB:6D2S"
/db_xref="UniProtKB/Swiss-Prot:O06581"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43883.1"
/translation="MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLST
SYVNQLENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHAVS
GAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAETELPPARPMPFEEVRD
FFYDRNNYIHDLDMAAERMFTESGMRTGGLDIQLAELMRDRFGISVVIDDNLPDTAKR
RYHPDTKVLRVAHWLMPGQRAFQIATQLALVGQSDLISSIVATDDQLSTEARGVARIG
LANYFAGAFLLPYREFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPF
IFVRTDKAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRSYF
WVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPSTEVPIGAGCKIC
NRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV"
gene 1254555..1256135
/gene="prpD"
/locus_tag="Rv1130"
CDS 1254555..1256135
/codon_start=1
/transl_table=11
/gene="prpD"
/locus_tag="Rv1130"
/product="Possible methylcitrate dehydratase PrpD"
/note="Rv1130, (MTCY22G8.19), len: 526 aa. Possible
prpD,methylcitrate dehydratase (MCD), some similarity to
AP000063|AP000063_192 hypothetical protein from Aeropyrum
pernix (479 aa), FASTA scores: opt: 717, E(): 0, (34.3%
identity in 443 a a overlap), and to PRPD_ECOLI|P77243
prpd protein from Escherichia coli (483aa), FASTA scores:
opt: 234, E(): 3.3e-08, (27.0% identity in 429 aa
overlap). Predicted possible vaccine candidate (See Zvi et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1130"
/db_xref="EnsemblGenomes-Tr:CCP43884"
/db_xref="GOA:O06582"
/db_xref="InterPro:IPR005656"
/db_xref="InterPro:IPR036148"
/db_xref="InterPro:IPR042183"
/db_xref="InterPro:IPR042188"
/db_xref="UniProtKB/Swiss-Prot:O06582"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43884.1"
/translation="MPDQDTKVRFFRVFCWCPVLRMVRIMLMHAVRAWRSADDFPCTE
HMAYKIAQVAADPVDVDPEVADMVCNRIIDNAAVSAASMVRRPVTVARHQALAHPVRH
GAKVFGVEGSYSADWAAWANGVAARELDFHDTFLAADYSHPADNIPPLVAVAQQLGVC
GAELIRGLVTAYEIHIDLTRGICLHEHKIDHVAHLGPAVAAGIGTMLRLDQETIYHAI
GQALHLTTSTRQSRKGAISSWKAFAPAHAGKVGIEAVDRAMRGEGSPAPIWEGEDGVI
AWLLAGPEHTYRVPLPAPGEPKRAILDSYTKQHSAEYQSQAPIDLACRLRERIGDLDQ
IASIVLHTSHHTHVVIGTGSGDPQKFDPDASRETLDHSLPYIFAVALQDGCWHHERSY
APERARRSDTVALWHKISTVEDPEWTRRYHCADPAKKAFGARAEVTLHSGEVIVDELA
VADAHPLGTRPFERKQYVEKFTELADGVVEPVEQQRFLAVVESLADLESGAVGGLNVL
VDPRVLDKAPVIPPGIFR"
gene 1256132..1257313
/gene="prpC"
/gene_synonym="gltA1"
/locus_tag="Rv1131"
CDS 1256132..1257313
/codon_start=1
/transl_table=11
/gene="prpC"
/gene_synonym="gltA1"
/locus_tag="Rv1131"
/product="Probable methylcitrate synthase PrpC"
/note="Rv1131, (MTCY22G8.20), len: 393 aa. Probable
prpC,methylcitrate synthase (MCS) (previously known as
gltA1) ,highly similar to CISY_MYCSM|P26491 citrate
synthase from Mycobacterium smegmatis (375 aa), FASTA
scores: opt:1942,E(): 0, (80.0% identity in 375 aa
overlap). Also similar to two other M. tuberculosis
citrate synthases,Rv0896c|MTCY31.24|gltA2 (431 aa), FASTA
score: (33.1% identity in 381 aa overlap) and
Rv0889|MTCY31.17c|citA (373 aa), FASTA score: (31.8%
identity in 371 aa overlap). Contains PS00480 Citrate
synthase signature. Belongs to the citrate synthase
family."
/db_xref="EnsemblGenomes-Gn:Rv1131"
/db_xref="EnsemblGenomes-Tr:CCP43885"
/db_xref="GOA:I6Y9Q3"
/db_xref="InterPro:IPR002020"
/db_xref="InterPro:IPR011278"
/db_xref="InterPro:IPR016142"
/db_xref="InterPro:IPR016143"
/db_xref="InterPro:IPR019810"
/db_xref="InterPro:IPR024176"
/db_xref="InterPro:IPR036969"
/db_xref="PDB:3HWK"
/db_xref="UniProtKB/Swiss-Prot:I6Y9Q3"
/inference="protein motif:PROSITE:PS00480"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43885.1"
/translation="MTGPLAAARSVAATKSMTAPTVDERPDIKKGLAGVVVDTTAISK
VVPQTNSLTYRGYPVQDLAARCSFEQVAFLLWRGELPTDAELALFSQRERASRRVDRS
MLSLLAKLPDNCHPMDVVRTAISYLGAEDPDEDDAAANRAKAMRMMAVLPTIVAIDMR
RRRGLPPIAPHSGLGYAQNFLHMCFGEVPETAVVSAFEQSMILYAEHGFNASTFAARV
VTSTQSDIYSAVTGAIGALKGRLHGGANEAVMHDMIEIGDPANAREWLRAKLARKEKI
MGFGHRVYRHGDSRVPTMKRALERVGTVRDGQRWLDIYQVLAAEMASATGILPNLDFP
TGPAYYLMGFDIASFTPIFVMSRITGWTAHIMEQATANALIRPLSAYCGHEQRVLPGT
F"
gene 1257325..1259055
/locus_tag="Rv1132"
CDS 1257325..1259055
/codon_start=1
/transl_table=11
/locus_tag="Rv1132"
/product="Conserved membrane protein"
/note="Rv1132, (MTCY22G8.21), len: 576 aa. Conserved
membrane protein, similar to O06827|Rv1431|MTCY493.23C
membrane protein from Mycobacterium tuberculosis (589
aa),fasta scores: opt: 1811, E(): 0, (48.2% identity in
585 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1132"
/db_xref="EnsemblGenomes-Tr:CCP43886"
/db_xref="GOA:O06583"
/db_xref="InterPro:IPR021941"
/db_xref="UniProtKB/TrEMBL:O06583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43886.1"
/translation="MGFLQPRLPDIDLAEWSQGSRSQKIRPMAQHWAEVGFGTPVLLH
LFYVAKILLYVLVGWLIVLTTKGIDGFTDAAAWYAEPIVFEKVVLYTMLFEVIGLGCG
FGPLNNRFFPPMGSILYWMRFGTIRLPPWPDRVPWTRGTKRKPVDVALYALLVMMLLS
ALFTDGAGPIPELGTTVGLLPAWQIVLILLLLGVLGLRDKVIFLAARGEVYATLTVTF
LFGRLNGIDMIVAAKLVFLVIWIGAATSKLNRHFPFVISTMMSNNPLFRPRFIKRMFF
KKFPGDLRPGLLSRIVAHVSTVIEMCVPVVLFVAHGGWPTVVAATIMVCFHLGILTAI
PMGVPLEWNVFMIFGVLSLFVGHACLGLADVKNPVPLAILIAVVAGIVIAGNVFPRKI
SFLAAMRYYAGNWDTTLWCIKPSAEDKINRGIVAIASMPAAQLERFYGKDRAQIPMYL
GYAFRAMNSHGRALFTLAHRAMAGHDEDDYVITDGERVCSTAVGWNFGDGHLHNEQLI
AAMQQRCGFQPGEVRVVLLDAQPIHRQTQEYRLVDAATGEFERGYVRVADMVNRQPWD
DDVPVHVLPG"
gene complement(1259067..1261346)
/gene="metE"
/locus_tag="Rv1133c"
CDS complement(1259067..1261346)
/codon_start=1
/transl_table=11
/gene="metE"
/locus_tag="Rv1133c"
/product="Probable 5-methyltetrahydropteroyltriglutamate--
homocysteine methyltransferase MetE (methionine synthase,
vitamin-B12 independent isozyme)"
/note="Rv1133c, (MTC22G8.22), len: 759 aa (start site
chosen by homology). Probable
metE,5-methyltetrahydropteroyltriglutamate--homocysteine
methyltransferase, highly similar to others e.g.
METE_ECOLI|P25665 Escherichia coli (752 aa), FASTA scores:
opt: 2251, E(): 0, (48.1% identity in 756 aa overlap).
Equivalent to Z94723|MLCB33_14 metE from M. leprae (760
aa) (85.3% identity in 755 aa overlap). Belongs to the
vitamin-B12 independent methionine synthase family."
/db_xref="EnsemblGenomes-Gn:Rv1133c"
/db_xref="EnsemblGenomes-Tr:CCP43887"
/db_xref="GOA:P9WK07"
/db_xref="InterPro:IPR002629"
/db_xref="InterPro:IPR006276"
/db_xref="InterPro:IPR013215"
/db_xref="InterPro:IPR038071"
/db_xref="UniProtKB/Swiss-Prot:P9WK07"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43887.1"
/translation="MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELE
AVAATLRRDTWSALAAAGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYF
AAARGTDQIAPLEMTKWFDTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARP
VIIGPITFLLLSKAVDGAGAPIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDL
SPDAPALAEAVYTALCSVSNRPAIYVATYFGDPGAALPALARTPVEAIGVDLVAGADT
SVAGVPELAGKTLVAGVVDGRNVWRTDLEAALGTLATLLGSAATVAVSTSCSTLHVPY
SLEPETDLDDALRSWLAFGAEKVREVVVLARALRDGHDAVADEIASSRAAIASRKRDP
RLHNGQIRARIEAIVASGAHRGNAAQRRASQDARLHLPPLPTTTIGSYPQTSAIRVAR
AALRAGEIDEAEYVRRMRQEITEVIALQERLGLDVLVHGEPERNDMVQYFAEQLAGFF
ATQNGWVQSYGSRCVRPPILYGDVSRPRAMTVEWITYAQSLTDKPVKGMLTGPVTILA
WSFVRDDQPLADTANQVALAIRDETVDLQSAGIAVIQVDEPALRELLPLRRADQAEYL
RWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDD
LNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRAVPAERLWVNPDCGLKTRNVD
EVTASLHNMVAAAREVRAG"
gene 1261922..1262158
/locus_tag="Rv1134"
CDS 1261922..1262158
/codon_start=1
/transl_table=11
/locus_tag="Rv1134"
/product="Hypothetical protein"
/note="Rv1134, (MTCI65.01), len: 78 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1134"
/db_xref="EnsemblGenomes-Tr:CCP43888"
/db_xref="UniProtKB/TrEMBL:O06534"
/protein_id="CCP43888.1"
/translation="MAAYQKFGQEHAAAIRGGAVLHPTATATTVRVTGARGGDVVTGD
GPYEAADLDEQGPFPMETVYLWEDGPNGTTRMTL"
gene complement(1262272..1264128)
/gene="PPE16"
/locus_tag="Rv1135c"
CDS complement(1262272..1264128)
/codon_start=1
/transl_table=11
/gene="PPE16"
/locus_tag="Rv1135c"
/product="PPE family protein PPE16"
/note="Rv1135c, (MTCI65.02c), len: 618 aa. PPE16, Member
of the Mycobacterium tuberculosis PPE family of
glycine-rich proteins. Similar to Rv2356c (59.6% identity
in 627 aa overlap); etc.. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1135c"
/db_xref="EnsemblGenomes-Tr:CCP43889"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI29"
/protein_id="CCP43889.1"
/translation="MSFLVLPPEVNSALMFAGAGSGPTLAAAAAWDGLAAELGQAANS
FSSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAAAQAKAAAAVYEAARA
ATVDPLLVAANRHQLVSLVLSNLFGQNAPAIAATEAAYEQLWAADVAAMVSYHSGASA
VAAQLAPWAQAVRALPNPTAPALASGPAALAIPALGIGNTGIGNIFSIGNIGDYNLGN
GNTGNANLGSGNTGQANLGSGNTGFFNFGSGNTANTNFGSGNLGNLNLGSGNDGNGNF
GLGNIGDGNRGSGNVGSFNFGTANAGSFNVGSANHGSPNVGFANLGNNNLGIANLGNN
NLGIANLGNNNIGIGLTGDNMIGIGALNSGIGNLGFGNSGNNNIGLFNSGNNNIGFFN
SGDSNFGFFNSGDTNTGFGNAGFTNTGFGNAGSGNFGFGNAGNNNFGFGNSGFENMGV
GNSGAYNTGSFNSGTLNTGDLNSGDFNTGWANSGDINTGGFHSGDLNTGFGSPVDQPV
MNSGFGNIGTGNSGFNNSGDANSGFQNTNTGAFFIGHSGLLNSGGGQHVGISNSGTGF
NTGLFNTGFNNTGIGNSATNAAFTTTSGVANSGDNSSGGFNAGNDQSGFFDG"
gene 1264314..1264556
/locus_tag="Rv1135A"
CDS 1264314..1264556
/codon_start=1
/transl_table=11
/locus_tag="Rv1135A"
/product="Possible acetyl-CoA acetyltransferase
(acetoacetyl-CoA thiolase)"
/note="Rv1135A, len: 80 aa. Possible acetyl-CoA
acetyltransferase (possible gene fragment), highly similar
to other acetyl-CoA acetyltransferases e.g. C-terminal
part of Rv3556c|Z92774|MTCY6G11_2|MTCY06G11.03|fadA6
acetyl-CoA acetyltransferase from Mycobacterium
tuberculosis (386 aa),FASTA scores: opt: 219, E():
5.7e-09, (63.6% identity in 55 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1135A"
/db_xref="EnsemblGenomes-Tr:CCP43890"
/db_xref="GOA:L7N682"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/TrEMBL:L7N682"
/protein_id="CCP43890.1"
/translation="MQLGNQNTMRFAGRPQRFRQSAYPLFNPNSAIALGHPFGGSGAR
LMTTVLHHMPDKGIRYGLQTMCEGRGQANATIVELL"
gene 1264606..1264947
/locus_tag="Rv1136"
CDS 1264606..1264947
/codon_start=1
/transl_table=11
/locus_tag="Rv1136"
/product="Possible enoyl-CoA hydratase"
/note="Rv1136, (MTCI65.03), len: 113 aa. Probable
enoyl-CoA hydratase (possible gene fragment). Some
similarity to N-terminus of carnitine racemases and
enoyl-CoA hydratases (but much shorter) e.g. I41014
carnitine racemase from Escherichia coli (297 aa), FASTA
scores: opt: 258, E(): 2.5e-11, (44.5% identity in 110 aa
overlap); and Rv0222 putative enoyl-CoA hydratase from M.
tuberculosis (262 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1136"
/db_xref="EnsemblGenomes-Tr:CCP43891"
/db_xref="GOA:O06536"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:O06536"
/protein_id="CCP43891.1"
/translation="MVITINRPEARNAVNGAVSIVVGDALEEAHDNPDVRAVVITGAG
DKSLCAGADLKAIARRENPYHPHHGEWGIAGYRHHFIDKPTSAAVSGTALDDGAEPAL
ASDLVVADEHT"
gene complement(1265087..1265455)
/locus_tag="Rv1137c"
CDS complement(1265087..1265455)
/codon_start=1
/transl_table=11
/locus_tag="Rv1137c"
/product="Hypothetical protein"
/note="Rv1137c, (MTCI65.04c), len: 122 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1137c"
/db_xref="EnsemblGenomes-Tr:CCP43892"
/db_xref="UniProtKB/TrEMBL:O06537"
/protein_id="CCP43892.1"
/translation="MLSARCHIRHIGSPGKDARCAHLSATLRPGIGISPTNVGNATVL
ADGTPAKPIQGAETMQRARHTGSCFSANARGPAISSGNPSRAGCGVPSSTTTPSSTPQ
AIRLLACTDSDALTVTRTAR"
gene complement(1265472..1266488)
/locus_tag="Rv1138c"
CDS complement(1265472..1266488)
/codon_start=1
/transl_table=11
/locus_tag="Rv1138c"
/product="Possible oxidoreductase"
/note="Rv1138c, (MTCI65.05c), len: 338 aa. Possible
oxidoreductase, similar to Q9EWQ8 putative oxidoreductase
from Streptomyces coelicolor (343 aa). Also similar to
many Mycobacterium tuberculosis hypothetical proteins e.g.
Rv1751|P72008|MTCY04C12.35 (412 aa), fasta scores: opt:
89,E(): 4.5e-09, (24.6% identity in 358 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1138c"
/db_xref="EnsemblGenomes-Tr:CCP43893"
/db_xref="GOA:O06538"
/db_xref="InterPro:IPR002938"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O06538"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43893.1"
/translation="MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPIDKA
CGEGLMPGGLAELTSLGVDPVGLPFHGIAYVGEHRRVQARFRTGPGRGVRRTTLHAAL
AARAKEQDTEWIRSRVATIQQDAHGVTAAGVRAKWLVAADGLHSAVRRAVGIKATAGT
PRRYGVRWHYRLPVWSDFVEVHWSRWGEAYVTPVEPDLVGVAILSRQRPELAWFPSLA
HHLQDASRGHARGCGPLRQVVSRRVAGRVLLVGDAAGYEDALTGEGISLAVKQAAAAV
SAIVDDTPASYEAAWHRITRDYRLVTRGLVLASTPRAARRAIVPLCALLPTAFRYGVN
ILAY"
gene complement(1266485..1266985)
/locus_tag="Rv1139c"
CDS complement(1266485..1266985)
/codon_start=1
/transl_table=11
/locus_tag="Rv1139c"
/product="Conserved hypothetical membrane protein"
/note="Rv1139c, (MTCI65.06c), len: 166 aa. Conserved
hypothetical membrane protein. Highly similar to
P54158|YBPQ_BACSU hypothetical Bacillus subtilis
protein,YBPQ (168 aa), FASTA scores: opt: 446, E():
2.2e-26, (38.4% identity in 164 aa overlap). Some
similarity to Mycobacterium tuberculosis hypothetical
proteins, Rv0740,Rv0750."
/db_xref="EnsemblGenomes-Gn:Rv1139c"
/db_xref="EnsemblGenomes-Tr:CCP43894"
/db_xref="GOA:O06539"
/db_xref="InterPro:IPR007269"
/db_xref="UniProtKB/TrEMBL:O06539"
/protein_id="CCP43894.1"
/translation="MYYLLILAVVFERLAELVVAQRNARWSFAQGGKEFGRPHYVVMV
ILHTALLLGCVVEPWALHRPFIPWLGWPMLAVVVASQGLRWWCVKSLGKRWNTRVIVL
PHATLVRRGPYRWMRHPNYVAVVAEGFALPLVHTAWLTALVFTLANATLLTVRLRVEN
SVLGYI"
gene 1267347..1268195
/locus_tag="Rv1140"
CDS 1267347..1268195
/codon_start=1
/transl_table=11
/locus_tag="Rv1140"
/product="Probable integral membrane protein"
/note="Rv1140, (MTCI65.07), len: 282 aa. Probable integral
membrane protein. Weak similarity in C-terminus to
hypothetical Escherichia coli proteins YPRA and
YPRB,possibly membrane-bound e.g. YPRA_ECOLI hypothetical
24.3 kDa protein (URF 1) (217 aa), FASTA scores: opt: 166,
E(): 0.00062, (31.0% identity in 158 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1140"
/db_xref="EnsemblGenomes-Tr:CCP43895"
/db_xref="GOA:O06540"
/db_xref="InterPro:IPR003675"
/db_xref="UniProtKB/TrEMBL:O06540"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43895.1"
/translation="MPRDYTAPRWAHAWAGEPRPARWHPANQPAHPDHSNRESPACMS
QSTTPYRSSVLAEFRRAITNVAVPHHEPPGIVRRRRVVVGVTLVIGAVMLGFSLRRTP
GESSFYWLTLALAAVWIAGALMSGPLHLGGICWRGRNQRPVITGTTVGLLLAGIFGVG
AMIVRAIPGAAEPIARVLQFAHQGTLLPILLITLINGIAEEMFFRGALYTALGRRYPV
TISTVLYVGATMASANLMLGFAAIFVGTVCALERRASGGVLAPILTHFVWGLIMVFAL
PPLFAV"
gene complement(1268203..1269009)
/gene="echA11"
/locus_tag="Rv1141c"
CDS complement(1268203..1269009)
/codon_start=1
/transl_table=11
/gene="echA11"
/locus_tag="Rv1141c"
/product="Probable enoyl-CoA hydratase EchA11 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv1141c, (MTCI65.08c), len: 268 aa. Probable
echA11,enoyl-CoA hydratase, similar to others e.g.
P24162|ECHH_RHOCA probable enoyl-CoA hydratase from
Rhodobacter capsulatus(257 aa); CAA66096.1|X97452
enoyl-CoA isomerase from Escherichia coli (262 aa), FASTA
scores: opt: 513, E():1e-25, (36.1% identity in 249 aa
overlap); etc. Also similarity with naphthoate synthases.
Also highly similar to downstream ORF
Rv1142c|MTCI65.09|echA10 probable enoyl-CoA hydratase from
Mycobacterium tuberculosis (268 aa), FASTA scores: opt:
1225, E(): 0, (72.3% identity in 267 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1141c"
/db_xref="EnsemblGenomes-Tr:CCP43896"
/db_xref="GOA:O06541"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:O06541"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43896.1"
/translation="MPDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTG
IADTLERAAADPVVKVVRLGGVGRGFSSGVSMSVDDVWGGGPPTAIVEEANRAVRAVA
ALPHPVVAVVQGPAVGVAVSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAA
TGRIRAMRLALLAEQLPAREALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQA
KNAINAAALTELEPTFARELDGQEVLLRTHDFAEGAAAFLQRRTPNFTGS"
gene complement(1269152..1269958)
/gene="echA10"
/locus_tag="Rv1142c"
CDS complement(1269152..1269958)
/codon_start=1
/transl_table=11
/gene="echA10"
/locus_tag="Rv1142c"
/product="Probable enoyl-CoA hydratase EchA10 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv1142c, (MTCI65.09c), len: 268 aa. Probable
echA10,enoyl-CoA hydratase, similar to others e.g.
CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia
coli (262 aa), FASTA scores: opt: 525, E(): 1.3e-26,
(35.1% identity in 251 aa overlap); NP_420658.1|NC_002696
enoyl-CoA hydratase/isomerase family protein from
Caulobacter crescentus (267 aa); NP_438092.1|NC_003078
putative enoyl-CoA hydratase protein from Sinorhizobium
meliloti (263 aa); etc. Also similarity with naphthoate
synthases. Also highly similar to upstream ORF
Rv1141c|MTCI65.08c|echA11 probable enoyl-CoA hydratase
from Mycobacterium tuberculosis (268 aa), FASTA score:
opt: 1225, E(): 0, (72.3% identity in 267 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1142c"
/db_xref="EnsemblGenomes-Tr:CCP43897"
/db_xref="GOA:O06542"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:O06542"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43897.1"
/translation="MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAG
MADAIEGAATDPRVKVVRLGGAGRGFSSGGAISVDDVWASGPPTDTVAEANRTVRAIV
ALPQPVVAVVQGPTVGCGVSLALACDLVLASDNAFFMLAHTNVGLMPDGGASALVQAA
IGRIRAMHMALLPDRVPAAEALSWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKT
KNAINAATLTELAPTLLRELDGQALLLRTDDFAEGATAFQQRRTPMFTGR"
gene 1270062..1271144
/gene="mcr"
/locus_tag="Rv1143"
CDS 1270062..1271144
/codon_start=1
/transl_table=11
/gene="mcr"
/locus_tag="Rv1143"
/product="Probable alpha-methylacyl-CoA racemase Mcr
(2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase
)"
/note="Rv1143, (MTCI65.10), len: 360 aa. Probable
mcr,alpha-methylacyl-CoA racemase. Strong similarity to
other alpha-methylacyl-CoA racemases and also some
similarity to L-carnitine dehydratase e.g. U89905|g1552373
methylacyl-CoA racemase alpha from Norway rat (361 aa),
FASTA scores: opt: 1035, E():0, (47.2% identity in 339 aa
overlap). Equivalent to (but longer than) Z94723|MLCB33_13
Mycobacterium leprae (253 aa) (85.3% identity in 245 aa
overlap). Also similar to Mycobacterium tuberculosis
putative racemases Rv0855,Rv1866, Rv3272."
/db_xref="EnsemblGenomes-Gn:Rv1143"
/db_xref="EnsemblGenomes-Tr:CCP43898"
/db_xref="GOA:O06543"
/db_xref="InterPro:IPR003673"
/db_xref="InterPro:IPR023606"
/db_xref="PDB:1X74"
/db_xref="PDB:2GCE"
/db_xref="PDB:2GCI"
/db_xref="PDB:2GD0"
/db_xref="PDB:2GD2"
/db_xref="PDB:2GD6"
/db_xref="PDB:2YIM"
/db_xref="UniProtKB/TrEMBL:O06543"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43898.1"
/translation="MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDG
ISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVTERLGLGPEECAKV
NDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHAIGRGDERPVPPLNLVGDFGGG
SMFLLVGILAALWERQSSGKGQVVDAAMVDGSSVLIQMMWAMRATGMWTDTRGANMLD
GGAPYYDTYECADGRYVAVGAIEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLT
EAFASHDRDHWGAVFANSDACVTPVLAFGEVHNEPHIIERNTFYEANGGWQPMPAPRF
SRTASSQPRPPAATIDIEAVLTDWDG"
gene 1271156..1271908
/locus_tag="Rv1144"
CDS 1271156..1271908
/codon_start=1
/transl_table=11
/locus_tag="Rv1144"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv1144, (MTCI65.11), len: 250 aa. Probable
short-chain dehydrogenase/reductase, highly similar to
various dehydrogenases e.g. NP_104056.1|NC_002678
3-hydroxyacyl-CoA dehydrogenase type II from Mesorhizobium
loti (253 aa); NP_251244.1|NC_002516 probable short-chain
dehydrogenase from Pseudomonas aeruginosa (255 aa);
AAK15008.1|AF233685_1|AF233685 short chain
L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus (261
aa); HSU73514|g1778354|XH98G2 human short-chain alcohol
dehydrogenase from Homo sapiens (261 aa), FASTA scores:
opt: 875, E(): 0, (60.1% identity in 253 aa overlap); etc.
Contains PS00061 Short-chain dehydrogenases/reductases
family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1144"
/db_xref="EnsemblGenomes-Tr:CCP43899"
/db_xref="GOA:P9WGQ7"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGQ7"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43899.1"
/translation="MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLRGDDVVG
GLGDRARFAQADVTDEAAVSNALELADSLGPVRVVVNCAGTGNAIRVLSRDGVFPLAA
FRKIVDINLVGTFNVLRLGAERIAKTEPIGEERGVIINTASVAAFDGQIGQAAYSASK
GGVVGMTLPIARDLASKLIRVVTIAPGLFDTPLLASLPAEAKASLGQQVPHPSRLGNP
DEYGALVLHIIENPMLNGEVIRLDGAIRMAPR"
gene 1272423..1273334
/gene="mmpL13a"
/locus_tag="Rv1145"
CDS 1272423..1273334
/codon_start=1
/transl_table=11
/gene="mmpL13a"
/locus_tag="Rv1145"
/product="Probable conserved transmembrane transport
protein MmpL13a"
/note="Rv1145, (MTCI65.12), len: 303 aa. Probable
mmpL13a,conserved transmembrane transport protein (see
citation below), member of RND superfamily, showing some
similarity to putative Mycobacterial and Streptomyces
membrane proteins e.g. MTCY987|g1781238 from Mycobacterium
tuberculosis (962 aa), FASTA scores: opt: 213, E():
1.9e-06, (28.0% identity in 296 aa overlap); etc. Strong
similarity to U92075|MMU92075_5 hypothetical protein from
Mycobacterium marinum (256 aa), FASTA scores: opt:
957,E(): 0, (57.6% identity in 257 aa overlap). Should
continue as mmpL13B|Rv1146, but frameshift required.
Sequence has been checked and is identical in M.
tuberculosis strain CDC1551, and Mycobacterium bovis
strain AF2122/97. Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv1145"
/db_xref="EnsemblGenomes-Tr:CCP43900"
/db_xref="GOA:O06545"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/TrEMBL:O06545"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43900.1"
/translation="MLQRIARLAIAAPRRIIGFAVFVFIAAAVFGVPVADSLSPGGFQ
DPRSESARAIEVLTDKFGQSGQKMLIVVTAAAGADSPPAREVGTDIVEVLRRSPLVYN
VTSPWTVPPTAAADLLSTDGKSGLIVVNVKGGENDAQNHAQTLSDEVAHDRDGVTVRA
GGSAMEYAQINRQNKDDLLVMELIAIPLSFLVLIWVFGGLLAAGLPMAQAVLAVVGSM
AVLRLVTFATEVSTFALNLSTALGLALAIDYTLLIVSRYRDELAEGSDRDEALIRTMA
LRGARCCFRRSPWRCRCRRLRCSRCTF"
gene 1273355..1274767
/gene="mmpL13b"
/locus_tag="Rv1146"
CDS 1273355..1274767
/codon_start=1
/transl_table=11
/gene="mmpL13b"
/locus_tag="Rv1146"
/product="Probable conserved transmembrane transport
protein MmpL13b"
/note="Rv1146, (MTCI65.13), len: 470 aa. Probable
mmpL13b,conserved transmembrane transport protein (see
citation below), member of RND superfamily, showing some
similarity to putative Mycobacterial and Streptomyces
membrane proteins e.g. Q53902|C40046 antibiotic
transport-associated protein from Streptomyces coelicolor
(711 aa), FASTA scores: opt: 193, E(): 2.1e-05, (28.9%
identity in 394 aa overlap); etc. Could be in frame with
previous ORF mmpL13A|Rv1145, but no sequence error
apparent to account for this; sequence is identical in M.
tuberculosis strain CDC1551, and Mycobacterium bovis
strain AF2122/97. Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv1146"
/db_xref="EnsemblGenomes-Tr:CCP43901"
/db_xref="GOA:O06546"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/TrEMBL:O06546"
/protein_id="CCP43901.1"
/translation="MATVAFVATASIVITPAAIVLLGPRLDALDVRRLVRRLLGRPDP
VHKPVKQLFWYRSSKFVMRRWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASA
RQVGDILRDDFGHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFV
DGSWVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVVMAGVA
QVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVCNVLSLTAAFGALV
WIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMDYEVFLVSRIREYWLESGAARP
ARRSVAEVHAANDESVALGVARTGRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTL
AVAADATLVRMVVVPAFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGGL
GKIAGRSDGQTIPASLTRNG"
gene 1274900..1275550
/locus_tag="Rv1147"
CDS 1274900..1275550
/codon_start=1
/transl_table=11
/locus_tag="Rv1147"
/product="Conserved protein"
/note="Rv1147, (MTCI65.14), len: 216 aa. Conserved
protein,similar to many conserved hypothetical proteins,
and some similarity to several methyltransferases e.g.
Q05197|PMTA_RHOSH phosphatidylethanolamine
N-methyltransferase from R. sphaeroides (203 aa), FASTA
scores: opt: 156, E(): 0.00073, (27.6% identity in 156 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1147"
/db_xref="EnsemblGenomes-Tr:CCP43902"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O06547"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43902.1"
/translation="MTSGAAASASRVDHPLFARIWPVVAAHEAEAIRALRRENLAGLS
GRVLEVGAGVGTNFAYYPVAVEQVIAMEPEPRLAAKARIAAADAPVPIVVTDKTVEEF
RDTETFDAVVCSLVLCSVSDPGAVLAHLRSLLRRGGELRYLEHVASAGARGRVQRFVD
ATFWPRLAGNCHTHRHTERAILDAGFVVDSSRREWAFPAWVPLPVSELALGRAHRT"
repeat_region 1276296..1277643
/note="REP-4, len: 1348 nt. REP165, member of REP13E12
family."
gene complement(1276300..1277748)
/locus_tag="Rv1148c"
CDS complement(1276300..1277748)
/codon_start=1
/transl_table=11
/locus_tag="Rv1148c"
/product="Conserved hypothetical protein"
/note="Rv1148c, (MTCI65.15c), len: 482 aa. Conserved
hypothetical ORF in REP13E12 degenerate repeat, nearly
identical to other hypothetical Mycobacterium tuberculosis
proteins in REP13E12 repeats, although similarity extends
upstream past proposed f-Met start. Very similar to other
REP13E12 proteins e.g. Rv1945, Rv3467, Rv0094c, Rv1128c
etc."
/db_xref="EnsemblGenomes-Gn:Rv1148c"
/db_xref="EnsemblGenomes-Tr:CCP43903"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P9WM55"
/protein_id="CCP43903.1"
/translation="MSETFCLTDHSEPMTARFLSVVLRRIRGMRSDTREEISAALDAY
HASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEELGGTL
RTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIK
EIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQE
RARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPLVDDTP
DADAVRRDTRSQAQRNHDAFLAALRGLLASGELGQHKGLPVTIVVSTTLKELEAATGK
GVTGGGSRVPMSDLIRMASHANHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGC
SRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAHGDTEW
LPPPHLDHGQPRINRYHHPAKILCEQDDDEPH"
mobile_element 1277843..1278826
/mobile_element_type="insertion sequence:IS-LIKE-2"
/note="IS-LIKE-2, len: 984 nt. Insertion sequence element
IS-LIKE."
repeat_region 1277843..1277846
/note="4 bp direct repeat, CTAG, generated by IS element
on insertion. Proposed by Mariani et al. 1993. J. Gen.
Microbiol., 139: 1767-1772. Note that as motif palindromic
could be part of inverted repeat itself."
repeat_region 1277847..1277863
/note="17 bp Inverted repeat at the left end of putative
IS-LIKE-2 element : GGCGTGTCTCCCAAATT. Proposed by Mariani
et al. 1993. J. Gen. Microbiol. 139: 1767-1772."
gene 1277893..1278300
/locus_tag="Rv1149"
CDS 1277893..1278300
/codon_start=1
/transl_table=11
/locus_tag="Rv1149"
/product="Possible transposase"
/note="Rv1149, (MTCI65.16), len: 135 aa. Possible
transposase. Identical to 117 aa N-terminal region of
S21394|X65618 transposase of Mycobacterium tuberculosis
(308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity
in 117 aa overlap). Second copy is Rv1042c|MTCY10G2.07."
/db_xref="EnsemblGenomes-Gn:Rv1149"
/db_xref="EnsemblGenomes-Tr:CCP43904"
/db_xref="InterPro:IPR025161"
/db_xref="UniProtKB/TrEMBL:L0T897"
/protein_id="CCP43904.1"
/translation="MTRVGVISDEFWAVVEPLMPSHEGKPGRRFSDHRLILEGIAWRF
RTGSPWRDLPAEFGPWQTVWKRHHRWSLDGTCDEVFAHVAAVFGVDAEVAEDIEKLLS
VDSTNVRAHQHSAGACSDTLATGGTVGLQEIRR"
gene 1278269..1278820
/pseudo
/locus_tag="Rv1150"
CDS 1278269..1278820
/codon_start=1
/transl_table=11
/locus_tag="Rv1150"
/product="Possible transposase (fragment)"
/note="Rv1150, (MTCI65.17), len: 183 aa. Possible fragment
of transposase (pseudogene). Identical to C-terminal part
of S21394 transposase of putative Mycobacterium
tuberculosis is element (308 aa), FASTA scores: opt:
959,E(): 0, (99.3% identity in 145 aa overlap). The
transposase described here may be made by a -1 frame
shifting mechanism during translation that fuses
Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found
to account for discrepancy with previously published
sequence. Second copy is Rv1041c|MTCY10G2.08."
/pseudogene="unknown"
repeat_region complement(1278800..1278816)
/note="17 bp Inverted repeat at the right end of putative
IS-LIKE-2 element :GGCGTGTCTCCCAATTT. Proposed by Mariani
et al. 1993. J. Gen. Microbiol. 139: 1767-1772"
repeat_region 1278817..1278820
/locus_tag="Rv1150"
/note="4 bp direct repeat, CTAG generated by IS element on
insertion. Proposed by Mariani et al. 1993. J. Gen.
Microbiol. 139: 1767-1772. Note that as motif palindromic
could be part of inverted repeat itself."
gene complement(1278904..1279617)
/locus_tag="Rv1151c"
CDS complement(1278904..1279617)
/codon_start=1
/transl_table=11
/locus_tag="Rv1151c"
/product="Transcriptional regulatory protein"
/note="Rv1151c, (MTCI65.18c), len: 237 aa. Transcriptional
regulatory protein, similar to others AE000776|AE000776_10
Aquifex aeolicus (239 aa), FASTA scores: opt: 725, E():
0,(46.4% identity in 237 aa overlap); ECAE0002125|g1787358
Escherichia coli (279 aa), FASTA scores: opt: 464, E():
1.3e-23, (36.7% identity in 240 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1151c"
/db_xref="EnsemblGenomes-Tr:CCP43906"
/db_xref="GOA:P9WGG3"
/db_xref="InterPro:IPR003000"
/db_xref="InterPro:IPR026590"
/db_xref="InterPro:IPR026591"
/db_xref="InterPro:IPR027546"
/db_xref="InterPro:IPR029035"
/db_xref="UniProtKB/Swiss-Prot:P9WGG3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43906.1"
/translation="MRVAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLR
NPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVSVITQNVDDLHERAGSGAVHH
LHGSLFEFRCARCGVPYTDALPEMPEPAIEVEPPVCDCGGLIRPDIVWFGEPLPEEPW
RSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVIEVNPEPTPLSGSATISIR
ESASQALPGLLERLPALLK"
gene 1279655..1280020
/locus_tag="Rv1152"
CDS 1279655..1280020
/codon_start=1
/transl_table=11
/locus_tag="Rv1152"
/product="Probable transcriptional regulatory protein"
/note="Rv1152, (MTCI65.19), len: 121 aa (Start uncertain).
Probable transcriptional regulatory protein, some
similarity to others e.g. YHCF_BACSU hypothetical
transcriptional regulator (121 aa), FASTA scores: opt:
187,E(): 1.9e-06, (34.9% identity in 106 aa overlap).
Helix turn helix motif from aa 42-63 (+3.10 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1152"
/db_xref="EnsemblGenomes-Tr:CCP43907"
/db_xref="GOA:O06550"
/db_xref="InterPro:IPR000524"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O06550"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43907.1"
/translation="MELRDWLRVDVKAGKPLFDQLRTQVIDGVRAGALPPGTRLPTVR
DLAGQLGVAANTVARAYRELESAAIVETRGRFGTFISRFDPTDAAMAAAAKEYVGVAR
ALGLTKSDAMRYLTHVPDD"
gene complement(1279998..1280846)
/gene="omt"
/locus_tag="Rv1153c"
CDS complement(1279998..1280846)
/codon_start=1
/transl_table=11
/gene="omt"
/locus_tag="Rv1153c"
/product="Probable O-methyltransferase Omt"
/note="Rv1153c, (MTCI65.20c), len: 282 aa. Probable
omt,O-methyltransferase, similar to TCMP_STRGA|P39887
Tetracenomycin polyketide synthesis O-methyltransferase
tcmP from Streptomyces glaucescens (270 aa), FASTA scores:
opt: 368, E(): 1.7e-17, (31.3% identity in 233 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1153c"
/db_xref="EnsemblGenomes-Tr:CCP43908"
/db_xref="GOA:O06551"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR016874"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O06551"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43908.1"
/translation="MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAV
ALVESIDFDFAKFGPTGQGFALRARAFDMAAQHYLDQHPAATVVALAEGLQTSFWRLD
VAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALDYSWMDSVDPAGGVFITA
EGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTSLRYKVPRMPF
SMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEF
SRPARG"
gene complement(1280843..1281484)
/locus_tag="Rv1154c"
CDS complement(1280843..1281484)
/codon_start=1
/transl_table=11
/locus_tag="Rv1154c"
/product="Hypothetical protein"
/note="Rv1154c, (MTCI65.21c), len: 213 aa. Hypothetical
unknown protein, start uncertain."
/db_xref="EnsemblGenomes-Gn:Rv1154c"
/db_xref="EnsemblGenomes-Tr:CCP43909"
/db_xref="InterPro:IPR012545"
/db_xref="UniProtKB/TrEMBL:O06552"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43909.1"
/translation="MEFPLITANSLSSKTWRAMPRAYVAVASFSGGLVQSGMAKFAAF
LRGVNVGGVNLKMAEVATALTDAGFCNVRTILASGNVLLESTCGAAEVREKTEATLRE
RFGYDAWALIYDVDTVRTIVTAYPFECELEGYQSYVTFVADAAILDELSALADTAGPD
ENISRGPDPLGVLYWQVPKGSTLDSTIGQTMGKKRYKSSTTTRNLRTLAKVLR"
gene 1281429..1281872
/locus_tag="Rv1155"
CDS 1281429..1281872
/codon_start=1
/transl_table=11
/locus_tag="Rv1155"
/product="Possible pyridoxamine 5'-phosphate oxidase
(PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX)
(pyridoxine 5'-phosphate oxidase)"
/note="Rv1155, (MTCI65.22), len: 147 aa. Possible
pyridoxine 5'-phosphate oxidase (PNPOx) (See Biswal et
al.,2005; Canaan et al., 2005). Similar to hypothetical
proteins e.g. AL079356|SC6G9.20 Streptomyces coelicolor
(144 aa), FASTA scores: opt: 478, E(): 2.8e-26, (55.7%
identity in 140 aa overlap); and Mycobacterium
tuberculosis proteins Rv1875, Rv0121c, Rv2074."
/db_xref="EnsemblGenomes-Gn:Rv1155"
/db_xref="EnsemblGenomes-Tr:CCP43910"
/db_xref="GOA:O06553"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR019920"
/db_xref="PDB:1W9A"
/db_xref="PDB:1XXO"
/db_xref="PDB:1Y30"
/db_xref="PDB:2AQ6"
/db_xref="PDB:4QVB"
/db_xref="UniProtKB/Swiss-Prot:O06553"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43910.1"
/translation="MARQVFDDKLLAVISGNSIGVLATIKHDGRPQLSNVQYHFDPRK
LLIQVSIAEPRAKTRNLRRDPRASILVDADDGWSYAVAEGTAQLTPPAAAPDDDTVEA
LIALYRNIAGEHSDWDDYRQAMVTDRRVLLTLPISHVYGLPPGMR"
gene 1282306..1282893
/locus_tag="Rv1156"
CDS 1282306..1282893
/codon_start=1
/transl_table=11
/locus_tag="Rv1156"
/product="Conserved protein"
/note="Rv1156, (MTCI65.23), len: 195 aa. Conserved
protein,highly similar to CAC32318.1|AL583944 conserved
hypothetical protein from Streptomyces coelicolor (197
aa)."
/db_xref="EnsemblGenomes-Gn:Rv1156"
/db_xref="EnsemblGenomes-Tr:CCP43911"
/db_xref="GOA:O06554"
/db_xref="InterPro:IPR003265"
/db_xref="InterPro:IPR011257"
/db_xref="InterPro:IPR017658"
/db_xref="UniProtKB/TrEMBL:O06554"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43911.1"
/translation="MPNLQLVQEPAADALLNANPFALLVGMLLDQQVPMETAFAGPKK
IADRMGSFDAGDIADYDPDKFVALCSERPAIHRFPGSMAKRIQALAQIIVDRYDGDAA
ALWTAGEPDGNELLRRLKGLPGFGEQKARIFLALLGKQYGVTPKGWQVAAGEFGQPGT
YLSVADIVDAGSLGQVRSHKRQRKAAAKAEGKAPT"
gene complement(1283056..1284171)
/locus_tag="Rv1157c"
CDS complement(1283056..1284171)
/codon_start=1
/transl_table=11
/locus_tag="Rv1157c"
/product="Conserved ala-, pro-rich protein"
/note="Rv1157c, (MTCI65.24c), len: 371 aa. Conserved
Ala-,Pro-rich protein, similar to other proline rich
proteins and extensins e.g. GBU04267|g451543 sea-island
cotton proline-rich protein of cotton fiber (214 aa),
FASTA scores: opt: 305, E(): 3.9e-05, (35.7% identity in
182 aa overlap). Has hydrophobic stretch at N-terminus
suggestive of secretion signal. First start taken. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1157c"
/db_xref="EnsemblGenomes-Tr:CCP43912"
/db_xref="GOA:O06555"
/db_xref="InterPro:IPR003882"
/db_xref="UniProtKB/TrEMBL:O06555"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43912.1"
/translation="MRRLTNTEHRENTTVASTWSVCKGLAAVVITSAAAFALCPNAAA
DPATPQPNPTQQLPGLPALAQLSPIIQQAAMNPAQATQLLMAAASAFAGNPAVPTESK
NVASSVNQFVAEPTNPDSAALGVPAPHGVALPEAIPVPHVPPLGAEPGVQAHLPTGID
PSHAAGPAPAVAPTVTPPVAAPPASAPAPAPDAAQPVAVPGPPPAPPAPRAAAPAPAS
AAPAPAAAPAPASGFGADAPPTQDFMYPSIGPNCVADGSNSIATALSVAGPAKIPLPG
PGPGQTAYVFTAVGTPGPADVQRLPLNVTWVNLTTGKSGSATLRPRSDINPDGPTTLT
VIADTGSGSIMSTIFGQVTTKDRQCQFMPTIGSTVVP"
gene 1283693..1283815
/gene="mcr10"
ncRNA 1283693..1283815
/gene="mcr10"
/product="Putative small regulatory RNA"
/note="mcr10, putative small regulatory RNA (See DiChiara
et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC
Pasteur, 3'-end not mapped, ~118 nt band detected by
Northern blot."
/ncRNA_class="other"
gene complement(1284179..1284862)
/locus_tag="Rv1158c"
CDS complement(1284179..1284862)
/codon_start=1
/transl_table=11
/locus_tag="Rv1158c"
/product="Conserved hypothetical ala-, pro-rich protein"
/note="Rv1158c, (MTCI65.25c), len: 227 aa. Conserved
hypothetical Ala-, Pro-rich protein, similar to other
proline rich proteins and extensins e.g. MMSAP62|g633250
house mouse (485 aa), FASTA scores: opt: 367, E():
1.2e-08,(36.3% identity in 212 aa overlap). Has
hydrophobic stretch at N-terminus suggestive of secretion
signal. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1158c"
/db_xref="EnsemblGenomes-Tr:CCP43913"
/db_xref="GOA:O06556"
/db_xref="UniProtKB/TrEMBL:O06556"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43913.1"
/translation="MPTIWTFVRAAAVLVGSSAALLTGGIAHADPAPAPAPAPNIPQQ
LISSAANAPQILQNLATALGATPPLSAPKVAEPAPAAPGITATFPGLTPAAPAAAAAP
ALTPSIPGVNAPIPGITPAAPALPVTAPAAAPTIPGVNAPIPGITAPAPAAAAVPASV
PGVPSAKVDLPQLPYLPLQVPQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPG
PPSLLAALP"
gene 1284992..1286287
/gene="pimE"
/locus_tag="Rv1159"
CDS 1284992..1286287
/codon_start=1
/transl_table=11
/gene="pimE"
/locus_tag="Rv1159"
/product="Mannosyltransferase PimE"
/note="Rv1159, (MTCI65.26), len: 431 aa.
PimE,mannosyltransferase (see Morita et al., 2006)
Conserved transmembrane protein, similar to others in
Mycobacterium tuberculosis e.g. Rv2181|MTCY21D4.13 (560
aa), FASTA scores: opt: 172; E(): 0.00035, (25.0% identity
in 332 aa overlap). Belongs to the GT-C superfamily of
glycosyltransferases (See Liu and Mushegian, 2003)."
/db_xref="EnsemblGenomes-Gn:Rv1159"
/db_xref="EnsemblGenomes-Tr:CCP43914"
/db_xref="GOA:P9WN01"
/db_xref="InterPro:IPR018584"
/db_xref="UniProtKB/Swiss-Prot:P9WN01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43914.1"
/translation="MCRTLIDGPVRSAIAKVRQIDTTSSTPAAARRVTSPPARETRAA
VLLLVLSVGARLAWTYLAPNGANFVDLHVYVSGAASLDHPGTLYGYVYADQTPDFPLP
FTYPPFAAVVFYPLHLVPFGLIALLWQVVTMAALYGAVRISQRLMGGTAETGHFAAML
WTAIAIWIEPLRSTFDYGQINVLLMLAALWAVYTPRWWLSGLLVGVASGVKLTPAITA
VYLVGVRRLHAAAFSVVVFLATVGVSLLVVGDEARYYFTDLLGDAGRVGPIATSFNQS
WRGAISRILGHDAGFGPLVLAAIASTAVLAILAWRALDRSDRLGKLLVVELFGLLLSP
ISWTHHWVWLVPLMIWLIDGPARERPGARILGWGWLVLTIVGVPWLLSFAQPSIWQIG
RPWYLAWAGLVYVVATLATLGWIAASERYVRIRPRRMAN"
gene complement(1286284..1286568)
/locus_tag="Rv1159A"
CDS complement(1286284..1286568)
/codon_start=1
/transl_table=11
/locus_tag="Rv1159A"
/product="Unknown protein"
/note="Rv1159A, len: 94 aa. Unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1159A"
/db_xref="EnsemblGenomes-Tr:CCP43915"
/db_xref="GOA:P9WI93"
/db_xref="InterPro:IPR001533"
/db_xref="InterPro:IPR036428"
/db_xref="UniProtKB/Swiss-Prot:P9WI93"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43915.1"
/translation="MAVLTDEQVDAALHDLNGWQRAGGVLRRSIKFPTFMAGIDAVRR
VAERAEEVNHHPDIDIRWRTVTFALVTHAVGGITENDIAMAHDIDAMFGA"
gene 1286595..1287020
/gene="mutT2"
/locus_tag="Rv1160"
CDS 1286595..1287020
/codon_start=1
/transl_table=11
/gene="mutT2"
/locus_tag="Rv1160"
/product="Probable mutator protein MutT2
(7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase)"
/note="Rv1160, (MTCI65.27), len: 141 aa. Probable
mutT2,mutator protein or homolog (see citation below).
More similar to D908197|g1742860 MutT homolog from
Escherichia coli (135 aa), FASTA scores: opt: 226,
E():1.1e-08, (39.7% identity in 116 aa overlap); than to
MUTT_ECOLI|P08337 mutator mutt protein from Escherichia
coli (129 aa), FASTA scores: opt: 180, E(): 1.2e-05,
(27.1% identity in 129 aa overlap). Contains PS00893 mutT
domain signature."
/db_xref="EnsemblGenomes-Gn:Rv1160"
/db_xref="EnsemblGenomes-Tr:CCP43916"
/db_xref="GOA:P9WIY1"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR020084"
/db_xref="InterPro:IPR020476"
/db_xref="UniProtKB/Swiss-Prot:P9WIY1"
/inference="protein motif:PROSITE:PS00893"
/protein_id="CCP43916.1"
/translation="MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGET
ERAALARELAEELGLEVADLAVGDRVGDDIALNGTTTLRAYRVHLLGGEPRARDHRAL
CWVTAAELHDVDWVPADRGWIADLARTLNGSAADVHRRC"
gene 1287328..1291026
/gene="narG"
/locus_tag="Rv1161"
CDS 1287328..1291026
/codon_start=1
/transl_table=11
/gene="narG"
/locus_tag="Rv1161"
/product="Respiratory nitrate reductase (alpha chain)
NarG"
/note="Rv1161, (MTCI65.28), len: 1232 aa. narG,
respiratory nitrate reductase alpha chain. Similar to
others e.g. NARG_BACSU nitratereductase alpha chain from
Bacillus subtilis (1228 aa), FASTA scores: opt: 4218, E():
0, (50.3% identity in 1229 aa overlap); etc. Also highly
similar to N-terminal part of Rv1736c|MTCY04C12.21c|NARX
probable nitrate reductase from Mycobacterium tuberculosis
(85.1% identity in 281 aa overlap). Contains prokaryotic
molybdopterin oxidoreductase signatures 1 and 2
(PS00551,PS00490). Belongs to the prokaryotic
molybdopterin-containing oxidoreductase family."
/db_xref="EnsemblGenomes-Gn:Rv1161"
/db_xref="EnsemblGenomes-Tr:CCP43917"
/db_xref="GOA:P9WJQ3"
/db_xref="InterPro:IPR006468"
/db_xref="InterPro:IPR006655"
/db_xref="InterPro:IPR006656"
/db_xref="InterPro:IPR006657"
/db_xref="InterPro:IPR006963"
/db_xref="InterPro:IPR009010"
/db_xref="InterPro:IPR027467"
/db_xref="InterPro:IPR037943"
/db_xref="UniProtKB/Swiss-Prot:P9WJQ3"
/inference="protein motif:PROSITE:PS00551"
/inference="protein motif:PROSITE:PS00490"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43917.1"
/translation="MTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDV
FYRDRWSHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEPRG
CPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKTRLGDPVLAWADIQADPERRRRYQ
QARGKGGLVRVSWAEASEMVAAAHVHTIKTYGPDRVAGFSPIPAMSMVSHAAGSRFVE
LIGGVMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDASYLVMWGSNVPITRTPDAH
WMAEARYRGAKVVVVSPDYADNTKFADEWVRCAAGTDTALAMAMGHVILSECYVRNQV
PFFVDYVRRYTDLPFLIKLEKRGDLLVPGKFLTAADIGEESENAAFKPALLDELTNTV
VVPQGSLGFRFGEDGVGKWNLDLGSVVPALSVEMDKAVNGDRSAELVTLPSFDTIDGH
GETVSRGVPVRRAGKHLVCTVFDLMLAHYGVARAGLPGEWPTGYHDRTQQNTPAWQES
ITGVPAAQAIRFAKEFARNATESGGRSMIIMGGGICHWFHSDVMYRSVLALLMLTGSM
GRNGGGWAHYVGQEKVRPLTGWQTMAMATDWSRPPRQVPGASYWYAHTDQWRYDGYGA
DKLASPVGRGRFAGKHTMDLLTSATAMGWSPFYPQFDRSSLDVADEARAAGRDVGDYV
AEQLAQHKLKLSITDPDNPVNWPRVLTVWRANLIGSSGKGGEYFLRHLLGTDSNVQSD
PPTDGVHPRDVVWDSDIPEGKLDLIMSIDFRMTSTTLVSDVVLPAATWYEKSDLSSTD
MHPYVHSFSPAIDPPWETRSDFDAFAAIARAFSALAKRHLGTRTDVVLTALQHDTPDE
MAYPDGTERDWLATGEVPVPGRTMSKLTVVERDYTAIYDKWLTLGPLIDQFGMTTKGY
TVHPFREVSELAANFGVMNSGVAVGRPAITTAKRMADVILALSGTCNGRLAVEGFLEL
EKRTGQRLAHLAEGSEERRITYADTQARPVPVITSPEWSGSESGGRRYAPFTINIEHL
KPFHTLTGRMHFYLAHDWVEELGEQLPVYRPPLDMARLFNQPELGPTDDGLGLTVRYL
TPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGDAAKINVRDNDWVEAVNANGIYVCR
AIVSHRMPEGVVFVYHVQERTVDTPRTETNGKRGGNHNALTRVRIKPSHLAGGYGQHA
FAFNYLGPTGNQRDEVTVVRRRSQEVRY"
gene 1291065..1292741
/gene="narH"
/locus_tag="Rv1162"
CDS 1291065..1292741
/codon_start=1
/transl_table=11
/gene="narH"
/locus_tag="Rv1162"
/product="Probable respiratory nitrate reductase (beta
chain) NarH"
/note="Rv1162, (MTCI65.29), len: 558 aa. Probable
narH,respiratory nitrate reductase beta chain. Similar to
others e.g. NARH_BACSU|P42176 nitrate reductase beta chain
from Bacillus subtilis (487 aa), FASTA scores: opt: 2049,
E(): 0, (56.8% identity in 488 aa overlap); etc. Contains
PS00190 cytochrome c family heme-binding site signature."
/db_xref="EnsemblGenomes-Gn:Rv1162"
/db_xref="EnsemblGenomes-Tr:CCP43918"
/db_xref="GOA:O06560"
/db_xref="InterPro:IPR006547"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR029263"
/db_xref="InterPro:IPR038262"
/db_xref="UniProtKB/TrEMBL:O06560"
/inference="protein motif:PROSITE:PS00190"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43918.1"
/translation="MKVMAQMAMVMNLDKCIGCHTCSVTCKQAWTNRSGTEYVWFNNV
ETRPGVGYPRTYEDQERWRGGWVRDKKGRLRLRDGGRIHKLLRIFANPKLPTIGDYYE
PWTYDYENLTSAPAGDTFPTAAPRSLISGNPMKVSWGSNWDDNLAGSPEIVPNDPVLK
KVNQVNQEVKLKLEETFMFYLPRICEHCLNPSCVASCPSGAMYKRTEDGIVLVDQDRC
RGWRMCVSGCPYKKVYFNHKTGKAEKCTLCYPRIEVGLPTVCSETCVGRLRYLGLVLY
DVDQVLQAASVESDTDLYEAQRRILLDPHDPRVIAGARAEGIADEWIEAAQRSPVYAL
INTYRVALPLHPEYRTMPMVWYIPPLSPVVDAVSRDGHDGEDLGNLFGALDALRIPIA
YLAELFTAGDTEVVAGVLRRLAAMRCYMRDINLGRETQPHIPESVGMTEEQIYQMYRL
LAVAKYEERYVIPTSYAGELPAAAMTDDMGCSLSVDGGPGMYESGPFGQGSPTPVPIA
VESFHALQHAGSAATGGAGRSRVNLLNWDPNGAAAGLFPEPQPSKDVVQR"
gene 1292798..1293403
/gene="narJ"
/locus_tag="Rv1163"
CDS 1292798..1293403
/codon_start=1
/transl_table=11
/gene="narJ"
/locus_tag="Rv1163"
/product="Probable respiratory nitrate reductase (delta
chain) NarJ"
/note="Rv1163, (MTCI65.30), len: 201 aa. Probable
narJ,respiratory nitrate reductase delta chain. Similar to
others e.g. P42178|NARJ_BACSU nitrate reductase delta
chain from Bacillus subtilis (184 aa), FASTA scores: opt:
254,E(): 1.9e-10, (31.8% identity in 179 aa overlap); etc.
Strong similarity to region from aa 260 - 410 of
Rv1736c|MTCY04C12.21c|NARX probable nitrate reductase from
Mycobacterium tuberculosis (64.8% identity in 159 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1163"
/db_xref="EnsemblGenomes-Tr:CCP43919"
/db_xref="GOA:O06561"
/db_xref="InterPro:IPR003765"
/db_xref="InterPro:IPR020945"
/db_xref="InterPro:IPR036411"
/db_xref="UniProtKB/TrEMBL:O06561"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43919.1"
/translation="MWQSASLLLAYPDDGLAERLHMVDALRAHQTGPAAALLGRTVAE
LRALAPMAAAAQYVETFDMRRRSTMYLTYWTAGDTRNRGREMLAFATAYRDAGVKPPR
TEAPDYLPVVLEFAATVDPEAGRRLLTEHRVPIDVLRGALADAKSPYEYTVAAICETL
PAATNQEVRRAQRLAQSGPPAEAVGLQPFTLTVPPKRAEGA"
gene 1293406..1294146
/gene="narI"
/locus_tag="Rv1164"
CDS 1293406..1294146
/codon_start=1
/transl_table=11
/gene="narI"
/locus_tag="Rv1164"
/product="Probable respiratory nitrate reductase (gamma
chain) NarI"
/note="Rv1164, (MTCI65.31), len: 246 aa. Probable
narI,respiratory nitrate reductase gamma chain. Similar to
others e.g. NARI_BACSU|P42177 nitrate reductase gamma
chain from Bacillus subtilis (223 aa), FASTA scores: opt:
652,E(): 0; (41.6% identity in 221 aa overlap); etc.
Highly similar to C-terminal part of
Rv1736c|MTCY04C12.21c|NARX probable nitrate reductase
(gamma chain) from Mycobacterium tuberculosis (68.6%
identity in 239 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1164"
/db_xref="EnsemblGenomes-Tr:CCP43920"
/db_xref="GOA:O06562"
/db_xref="InterPro:IPR003816"
/db_xref="InterPro:IPR023234"
/db_xref="InterPro:IPR036197"
/db_xref="UniProtKB/TrEMBL:O06562"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43920.1"
/translation="MAVLDLVEIFWDAAPYVVVAIAVVGTWWRYRYDKFGWTTRSSQL
YESRLLSIGSPMFHFGSLLVIMGHVMGLFIPDSWTRAFGMSDHLYHLQALLLGAPAGF
ATLLGIGLLIYRRRIQTPVWLATTRNDKLMYLVLVCAIVAGLACTLMGATHEGDMHDY
RRSVSVWFRSIWMLAPRGDLMAQATLYYQVHVLIALALFALWPFTRLVHAFSAPIAYL
FRPYIVYRSREVAAKHELIGSAPRRRGW"
gene 1294168..1296054
/gene="typA"
/gene_synonym="bipA"
/locus_tag="Rv1165"
CDS 1294168..1296054
/codon_start=1
/transl_table=11
/gene="typA"
/gene_synonym="bipA"
/locus_tag="Rv1165"
/product="Possible GTP-binding translation elongation
factor TypA (tyrosine phosphorylated protein A)
(GTP-binding protein)"
/note="Rv1165, (MTV005.01-MTCI65.32), len: 628 aa.
Possible typA (alternate gene name: bipA), GTP-binding
translation elongation factor, similar to several e.g.
P32132|TYPA_ECOLI|BIPA|B387 Escherichia coli (591 aa);
YIHK_SYNY3|P72749 gtp-binding protein TYPA/BIPA homolog
from synechocystis sp. (597 aa), FASTA scores: E():
0,(46.9% identity in 610 aa overlap); and to elongation
factor EF-G from many organims e.g. EFG_MICLU|P09952
micrococcus luteus (701 aa), FASTA scores: E():
3e-24,(29.8% identity in 500 aa overlap). Belongs to the
GTP-binding elongation factor family, TYPA subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1165"
/db_xref="EnsemblGenomes-Tr:CCP43921"
/db_xref="GOA:O06563"
/db_xref="InterPro:IPR000640"
/db_xref="InterPro:IPR000795"
/db_xref="InterPro:IPR004161"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR006298"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR035647"
/db_xref="InterPro:IPR035651"
/db_xref="InterPro:IPR042116"
/db_xref="UniProtKB/TrEMBL:O06563"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43921.1"
/translation="MPFRNVAIVAHVDHGKTTLVDAMLRQSGALRERGELQERVMDTG
DLEREKGITILAKNTAVHRHHPDGTVTVINVIDTPGHADFGGEVERGLSMVDGVLLLV
DASEGPLPQTRFVLRKALAAHLPVILVVNKTDRPDARIAEVVDASHDLLLDVASDLDD
EAAAAAEHALGLPTLYASGRAGVASTTAPPDGQVPDGTNLDPLFEVLEKHVPPPKGEP
DAPLQALVTNLDASTFLGRLALIRIYNGRIRKGQQVAWIRQVDGQQTVTTAKITELLA
TEGVERKPTDAAVAGDIVAVAGLPEIMIGDTLAASANPVALPRITVDEPAISVTIGTN
TSPLAGKVGGHKLTARMVRSRLDAELVGNVSIRVVDIGAPDAWEVQGRGELALAVLVE
QMRREGFELTVGKPQVVTKTIDGTLHEPFESMTVDCPEEYIGAVTQLMAARKGRMVEM
ANHTTGWVRMDFVVPSRGLIGWRTDFLTETRGSGVGHAVFDGYRPWAGEIRARHTGSL
VSDRAGAITPFALLQLADRGQFFVEPGQQTYEGMVVGINPRPEDLDINVTREKKLTNM
RSSTADVIETLAKPLQLDLERAMELCAPDECVEVTPEIVRIRKVELAAAARARSRART
KARG"
gene 1296152..1298059
/gene="lpqW"
/locus_tag="Rv1166"
CDS 1296152..1298059
/codon_start=1
/transl_table=11
/gene="lpqW"
/locus_tag="Rv1166"
/product="Probable conserved lipoprotein LpqW"
/note="Rv1166, (MTV005.02), len: 635 aa. Probable
lpqW,conserved lipoprotein, almost identical in part to
G2384665|AF009358 Mycobacterium tuberculosis gene fragment
ORFA2-898 (fragment) (59 aa) (93.9% identity in 49 aa
overlap) (see * below). Also similar to Rv1280c and
Rv2585c. Contains possible N-terminal signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site. [* Note: Unpublished.
Identification of Mycobacterium tuberculosis peptides that
stimulate immune human peripheral blood monocytes. Nano
F.E., Doran J.L., Treit J.D., Moran A.J.]"
/db_xref="EnsemblGenomes-Gn:Rv1166"
/db_xref="EnsemblGenomes-Tr:CCP43922"
/db_xref="GOA:P9WGU7"
/db_xref="InterPro:IPR000914"
/db_xref="InterPro:IPR039424"
/db_xref="UniProtKB/Swiss-Prot:P9WGU7"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43922.1"
/translation="MGVPSPVRRVCVTVGALVALACMVLAGCTVSPPPAPQSTDTPRS
TPPPPRRPTQIIMGIDWIGPGFNPHLLSDLSPVNAAISALVLPSAFRPIPDPNTPTGS
RWEMDPTLLVSADVTNNHPFTVTYKIRPEAQWTDNAPIAADDFWYLWQQMVTQPGVVD
PAGYHLITSVQSLEGGKQAVVTFAQPYPAWRELFTDILPAHIVKDIPGGFASGLARAL
PVTGGQFRVENIDPQRDEILIARNDRYWGPPSKPGIILFRRAGAPAALADSVRNGDTQ
VAQVHGGSAAFAQLSAIPDVRTARIVTPRVMQFTLRANVPKLADTQVRKAILGLLDVD
LLAAVGAGTDNTVTLDQAQIRSPSDPGYVPTAPPAMSSAAALGLLEASGFQVDTNTSV
SPAPSVPDSTTTSVSTGPPEVIRGRISKDGEQLTLVIGVAANDPTSVAVANTAADQLR
DVGIAATVLALDPVTLYHDALNDNRVDAIVGWRQAGGNLATLLASRYGCPALQATTVP
AANAPTTAPSAPIGPTPSAAPDTATPPPTAPRRPSDPGALVKAPSNLTGICDRSIQSN
IDAALNGTKNINDVITAVEPRLWNMSTVLPILQDTTIVAAGPSVQNVSLSGAVPVGIV
GDAGQWVKTGQ"
gene complement(1298087..1298692)
/locus_tag="Rv1167c"
CDS complement(1298087..1298692)
/codon_start=1
/transl_table=11
/locus_tag="Rv1167c"
/product="Probable transcriptional regulatory protein"
/note="Rv1167c, (MTV005.03c), len: 201 aa. Probable
transcriptional regulator, similar to several e.g.
D1022772|D85417 hemR from Propionibacterium freudenreichii
(243 aa), FASTA scores: opt: 268, E(): 5.4e-16, (35.9%
identity in 198 aa overlap) and AL022268|SC4H2.32
Streptomyces coelicolor (111 aa), FASTA scores: opt:
274,E(): 5e-11, (55.1% identity in 89 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1167c"
/db_xref="EnsemblGenomes-Tr:CCP43923"
/db_xref="GOA:O50423"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR011075"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O50423"
/protein_id="CCP43923.1"
/translation="MTVSAPAKANPYRRRGEVLERALYDATLAELESAGYGGLTMEGI
AARAQTGKAALYRRWAGKRELVLAAVQYALPPVPEPRADRSARENLLAVFTANCEILA
GKTALPSMEIVSQLLHEPELRAIFINSVWAPRLRIVESILQAGVRSGEIDPATLTPMT
ARIGPALIHQHVLFTGSPPDREQLTRIIDAMILTTGERRES"
gene complement(1298764..1299804)
/gene="PPE17"
/locus_tag="Rv1168c"
CDS complement(1298764..1299804)
/codon_start=1
/transl_table=11
/gene="PPE17"
/locus_tag="Rv1168c"
/product="PPE family protein PPE17"
/note="Rv1168c, (MTV005.04c), len: 346 aa. PPE17, Member
of the Mycobacterium tuberculosis PPE family of
glycine-rich proteins, similar to many e.g.
E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt:
504, E(): 0, (36.6% identity in 388 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1168c"
/db_xref="EnsemblGenomes-Tr:CCP43924"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI27"
/protein_id="CCP43924.1"
/translation="MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFE
SEINGLITSWRGPSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHV
PLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAAR
LTPFSPPAPIANPGALARLYELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTA
ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNA
DTIGGLSVPPSWVADKSITPLAKAVPTSAPGGPSGTSWAQLGLASLAGGAVGAVAART
RSGVILRSPAAG"
gene complement(1299822..1300124)
/gene="lipX"
/gene_synonym="PE11"
/locus_tag="Rv1169c"
CDS complement(1299822..1300124)
/codon_start=1
/transl_table=11
/gene="lipX"
/gene_synonym="PE11"
/locus_tag="Rv1169c"
/product="PE family protein. Possible lipase LipX."
/note="Rv1169c, (MTV005.05c), len: 100 aa. Possible
lipX,lipase. Member of the Mycobacterium tuberculosis PE
family of proteins (see Brennan & Delogu 2002), e.g.
O05297|Z93777|MTCI364.07 (99 aa), FASTA scores: opt:
209,E(): 1.6e-15, (37.4% identity in 99 aa overlap). Also
simlar to the N-terminus of P77909|U76006 esterase/lipase
from Mycobacterium tuberculosis (437 aa), FASTA scores:
opt: 193, E(): 4.4e-14, (37.2% identity in 94 aa overlap).
Contains a helix-turn-helix motif from aa 88-109 (+2.76
SD). Predicted possible vaccine candidate (See Zvi et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1169c"
/db_xref="EnsemblGenomes-Tr:CCP43925"
/db_xref="GOA:Q79FR5"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43925.1"
/translation="MSFVTTRPDSIGETAANLHEIGVTMSAHDDGVTPLITNVESPAH
DLVSIVTSMLFSMHGELYKAIARQAHVIHESFVQTLQTSKTSYWLTELANRAGTST"
gene 1300304..1301215
/gene="mshB"
/locus_tag="Rv1170"
CDS 1300304..1301215
/codon_start=1
/transl_table=11
/gene="mshB"
/locus_tag="Rv1170"
/product="N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-
D-glucopyranoside deacetylase MshB (GlcNAc-Ins
deacetylase)"
/note="Rv1170, (MTV005.06), len: 303 aa. MshB,
N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-
Glucopyranoside Deacetylase (GlcNAc-Ins deacetylase) (see
citation below),similar to Q54358|X79146 lmbE gene from
Streptomyces lincolnensis (270 aa), FASTA scores: opt:
308, E(): 1.2e-15, (32.0% identity in 278 aa overlap).
Also similar to Rv1082|MCA Mycothiol conjugate amidase
from Mycobacterium tuberculosis (288 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1170"
/db_xref="EnsemblGenomes-Tr:CCP43926"
/db_xref="GOA:P9WJN3"
/db_xref="InterPro:IPR003737"
/db_xref="InterPro:IPR017810"
/db_xref="InterPro:IPR024078"
/db_xref="PDB:1Q74"
/db_xref="PDB:1Q7T"
/db_xref="PDB:4EWL"
/db_xref="UniProtKB/Swiss-Prot:P9WJN3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43926.1"
/translation="MSETPRLLFVHAHPDDESLSNGATIAHYTSRGAQVHVVTCTLGE
EGEVIGDRWAQLTADHADQLGGYRIGELTAALRALGVSAPIYLGGAGRWRDSGMAGTD
QRSQRRFVDADPRQTVGALVAIIRELRPHVVVTYDPNGGYGHPDHVHTHTVTTAAVAA
AGVGSGTADHPGDPWTVPKFYWTVLGLSALISGARALVPDDLRPEWVLPRADEIAFGY
SDDGIDAVVEADEQARAAKVAALAAHATQVVVGPTGRAAALSNNLALPILADEHYVLA
GGSAGARDERGWETDLLAGLGFTASGT"
gene 1301307..1301747
/locus_tag="Rv1171"
CDS 1301307..1301747
/codon_start=1
/transl_table=11
/locus_tag="Rv1171"
/product="Conserved hypothetical protein"
/note="Rv1171, (MTV005.07), len: 146 aa. Conserved
hypothetical protein, possibly transmembrane protein.
Start has been changed since first submission."
/db_xref="EnsemblGenomes-Gn:Rv1171"
/db_xref="EnsemblGenomes-Tr:CCP43927"
/db_xref="GOA:O50427"
/db_xref="UniProtKB/TrEMBL:O50427"
/protein_id="CCP43927.1"
/translation="MGHRVDTLSDRQRANLTTGATDRAIRLVVLALLTVDGVVSALAG
ALLMPWYIGSAPFPISALISGLVNAALVWAAARWTTSSRVAALPLWAWLLTVAAMSFG
GPGDDVILGGQGLLVYGALVFVVAGAVPPAWVLWRRRVQADGSG"
gene complement(1301755..1302681)
/gene="PE12"
/locus_tag="Rv1172c"
CDS complement(1301755..1302681)
/codon_start=1
/transl_table=11
/gene="PE12"
/locus_tag="Rv1172c"
/product="PE family protein PE12"
/note="Rv1172c, (MTV005.08c), len: 308 aa. PE12, Member of
the Mycobacterium tuberculosis PE family of proteins (see
Brennan & Delogu 2002), e.g. P71748|Z81368|MTCY253.25C
(361 aa), FASTA scores: opt: 483, E(): 7.8e-22, (46.4%
identity in 192 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1172c"
/db_xref="EnsemblGenomes-Tr:CCP43928"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N693"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43928.1"
/translation="MSFVFAAPEALAAAAADMAGIGSTLNAANVVAAVPTTGVLAAAA
DEVSTQVAALLSAHAQGYQQLSRQMMTAFHDQFVQALRASADAYATAEASAAQTMVNA
VNAPARALLGHPLISADASTGGGSNALSRVQSMFLGTGGSSALGGSAAANAAASGALQ
LQPTGGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLT
AWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALTNIETATAA
SINQFINTEINWIRGFLPPLPPISPPGFPSLP"
gene 1302931..1305501
/gene="fbiC"
/locus_tag="Rv1173"
CDS 1302931..1305501
/codon_start=1
/transl_table=11
/gene="fbiC"
/locus_tag="Rv1173"
/product="Probable F420 biosynthesis protein FbiC"
/note="Rv1173, (MTV005.09), len: 856 aa. Probable
fbiC,F420 biosynthesis protein, equivalent to
AAL91922|FBIC F420 biosynthesis protein fbiC from
Mycobacterium bovis BCG (856 aa) (see citation below). The
N-terminus (aa 80-420) is similar to Y446_METJA|Q57888
hypothetical protein mj0446 from methanococcus jannaschii
(361 aa), FASTA scores: opt: 801, E(): 0, (41.2% identity
in 337 aa overlap); and the C-terminus region (aa 530-856)
is similar to e.g. YE31_METJA|Q58826 hypothetical protein
mj1431 from methanococcus jannaschii (359 aa), FASTA
scores: opt: 1089,E(): 0, (48.7% identity in 337 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1173"
/db_xref="EnsemblGenomes-Tr:CCP43929"
/db_xref="GOA:P9WP77"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR019939"
/db_xref="InterPro:IPR019940"
/db_xref="InterPro:IPR020050"
/db_xref="InterPro:IPR034405"
/db_xref="UniProtKB/Swiss-Prot:P9WP77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43929.1"
/translation="MPQPVGRKSTALPSPVVPPQANASALRRVLRRARDGVTLNVDEA
AIAMTARGDELADLCASAARVRDAGLVSAGRHGPSGRLAISYSRKVFIPVTRLCRDNC
HYCTFVTVPGKLRAQGSSTYMEPDEILDVARRGAEFGCKEALFTLGDRPEARWRQARE
WLGERGYDSTLSYVRAMAIRVLEQTGLLPHLNPGVMSWSEMSRLKPVAPSMGMMLETT
SRRLFETKGLAHYGSPDKDPAVRLRVLTDAGRLSIPFTTGLLVGIGETLSERADTLHA
IRKSHKEFGHIQEVIVQNFRAKEHTAMAAFPDAGIEDYLATVAVARLVLGPGMRIQAP
PNLVSGDECRALVGAGVDDWGGVSPLTPDHVNPERPWPALDELAAVTAEAGYDMVQRL
TAQPKYVQAGAAWIDPRVRGHVVALADPATGLARDVNPVGMPWQEPDDVASWGRVDLG
AAIDTQGRNTAVRSDLASAFGDWESIREQVHELAVRAPERIDTDVLAALRSAERAPAG
CTDGEYLALATADGPALEAVAALADSLRRDVVGDEVTFVVNRNINFTNICYTGCRFCA
FAQRKGDADAYSLSVGEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKAR
VPSMHVHAFSPMEIANGVTKSGLSIREWLIGLREAGLDTIPGTAAEILDDEVRWVLTK
GKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWVAHLNVLRDIQDRTGGFTEFV
PLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGRISHIQTSWVKLGVRRTQV
MLEGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGIGRPARQRTTTYALLAA
"
repeat_region 1305495..1305556
/note="62 bp direct repeat copy 1,
GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCA
ATCT"
repeat_region 1305557..1305618
/note="62 bp direct repeat copy 2,
GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCA
ATCT"
repeat_region 1305619..1305661
/note="62 bp direct repeat partial copy 3 (43/62
bp),GGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGGGGCCCG"
gene complement(1305669..1306001)
/gene="TB8.4"
/locus_tag="Rv1174c"
CDS complement(1305669..1306001)
/codon_start=1
/transl_table=11
/gene="TB8.4"
/locus_tag="Rv1174c"
/product="Low molecular weight T-cell antigen TB8.4"
/note="Rv1174c, (MTV005.10c), len: 110 aa. TB8.4, low
molecular weight T-cell antigen (see citations
below),hypothetical unknown secreted protein. Predicted to
be an outer membrane protein (See Song et al., 2008).
Predicted possible vaccine candidate (See Zvi et al.,
2008)."
/db_xref="EnsemblGenomes-Gn:Rv1174c"
/db_xref="EnsemblGenomes-Tr:CCP43930"
/db_xref="GOA:O50430"
/db_xref="InterPro:IPR016572"
/db_xref="InterPro:IPR032407"
/db_xref="UniProtKB/TrEMBL:O50430"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43930.1"
/translation="MRLSLTALSAGVGAVAMSLTVGAGVASADPVDAVINTTCNYGQV
VAALNATDPGAAAQFNASPVAQSYLRNFLAAPPPQRAAMAAQLQAVPGAAQYIGLVES
VAGSCNNY"
gene complement(1306202..1308226)
/gene="fadH"
/locus_tag="Rv1175c"
CDS complement(1306202..1308226)
/codon_start=1
/transl_table=11
/gene="fadH"
/locus_tag="Rv1175c"
/product="Probable NADPH dependent 2,4-dienoyl-CoA
reductase FadH (2,4-dienoyl coenzyme A reductase)
(4-enoyl-CoA reductase)"
/note="Rv1175c, (MTV005.11c), len: 674 aa. Probable
fadH,NADPH-dependent 2,4-dienoyl-CoA reductase, highly
similar to others e.g. NP_251782.1|NC_002516
2,4-dienoyl-CoA reductase FadH1 from Pseudomonas
aeruginosa (679 aa); CAC01564.1|AL391039 2,4-dienoyl-CoA
reductase [NADPH] from Streptomyces coelicolor (671 aa);
P42593|FADH_ECOLI 2,4-dienoyl-CoA reductase from
Escherichia coli (671 aa),FASTA scores: opt: 2344, E(): 0,
(53.1% identity in 671 aa overlap); etc. Also similar to
Rv3359|MTV004.16 putative oxidoreductase from
Mycobacterium tuberculosis (396 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1175c"
/db_xref="EnsemblGenomes-Tr:CCP43931"
/db_xref="GOA:O50431"
/db_xref="InterPro:IPR001155"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O50431"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43931.1"
/translation="MTNPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDRARHIDRLAD
YFAERARGGVGLIITGGYAPNRTGWLLPFASELVTSAQARRHRRITRAVHDSGAKILL
QILHAGRYAYHPLAVSASPIKAPITPFRPRALSARGVEATIADFARCAQLARDAGYDG
VEIMGSEGYLLNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSRAAVGCDFIICYRL
SMADYVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDISS
AVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLKAQSNRVDEI
NTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRRARSVAVVGAGPAGLATA
ANAAQRGHRVTLFEANDFIGGQFDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTR
VAAQELTGYDEVVLATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGI
GFDVTELLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGP
QGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVV
VCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGTELAARL"
gene complement(1308223..1308792)
/locus_tag="Rv1176c"
CDS complement(1308223..1308792)
/codon_start=1
/transl_table=11
/locus_tag="Rv1176c"
/product="Conserved hypothetical protein"
/note="Rv1176c, (MTV005.12c), len: 189 aa. Conserved
hypothetical protein, some similarity to P94443|D78508
hypothetical protein from Bacillus subtilis (182 aa),
FASTA scores: opt: 219, E(): 1.7e-15, (25.1% identity in
183 aa overlap). Similar to Mycobacterium tuberculosis
hypothetical protein Rv0047c."
/db_xref="EnsemblGenomes-Gn:Rv1176c"
/db_xref="EnsemblGenomes-Tr:CCP43932"
/db_xref="GOA:O50432"
/db_xref="InterPro:IPR005149"
/db_xref="InterPro:IPR018309"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O50432"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43932.1"
/translation="MALPHAILVSLCEQASSGYELARRFDRSIGYFWTATHQQIYRTL
RVMENNNWVRATTVLQHGRPDKKVYAISDSGRAELARWIAEPLSPTRPGRGSALTDSS
TRDIAVKLRGAGYGDVAALYTQVTALRAERVKSLDTYRGIEKRTFADPSALDGAALHQ
YLVLRGGIRAEESAIDWLDEVAEALQEKR"
gene 1309005..1309331
/gene="fdxC"
/locus_tag="Rv1177"
CDS 1309005..1309331
/codon_start=1
/transl_table=11
/gene="fdxC"
/locus_tag="Rv1177"
/product="Probable ferredoxin FdxC"
/note="Rv1177, (MTV005.13), len: 108 aa. Probable
fdxC,ferredoxin, equivalent to NP_302047.1|NC_002677
ferredoxin from Mycobacterium leprae (108 aa);
P00215|FER_MYCSM ferredoxin from Mycobacterium smegmatis
(106 aa), FASTA scores: opt: 705, E(): 0, (87.7% identity
in 106 aa overlap). Also highly similar to many e.g.
JH0239 ferredoxin precursor from Saccharopolyspora
erythraea (105 aa); P24496|FER_SACER ferredoxin from
Saccharopolyspora erythraea (106 aa); etc. Contains
PS00198 4Fe-4S ferredoxins, iron-sulfur binding region
signature. Belongs to the bacterial type ferredoxin
family. Cofactor: binds 1 4FE-4S cluster and a 3FE-4S
cluster (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv1177"
/db_xref="EnsemblGenomes-Tr:CCP43933"
/db_xref="GOA:O50433"
/db_xref="InterPro:IPR000813"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR017900"
/db_xref="UniProtKB/TrEMBL:O50433"
/inference="protein motif:PROSITE:PS00198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43933.1"
/translation="MTYTIAEPCVDIKDKACIEECPVDCIYEGARMLYIHPDECVDCG
ACEPVCPVEAIFYEDDVPEQWSHYTQINADFFAELGSPGGAAKVGMTENDPQAVKDLA
PQSEDA"
gene 1309364..1310452
/locus_tag="Rv1178"
CDS 1309364..1310452
/codon_start=1
/transl_table=11
/locus_tag="Rv1178"
/product="Probable aminotransferase"
/note="Rv1178, (MTV005.14), len: 362 aa. Probable
aminotransferase, weak similarity to many aspartate
aminotransferases e.g. Q55679|D64000 SLL0006 aspartate
aminotransferase from Synechocystis sp. (394 aa), FASTA
scores: opt: 218, E(): 1.3e-25, (32.5% identity in 379 aa
overlap). Contains PS00105 Aminotransferases class-I
pyridoxal-phosphate attachment site. Also similar to
Mycobacterium tuberculosis aminotransferases
Rv2294,Rv0075, etc."
/db_xref="EnsemblGenomes-Gn:Rv1178"
/db_xref="EnsemblGenomes-Tr:CCP43934"
/db_xref="GOA:O50434"
/db_xref="InterPro:IPR004838"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR019880"
/db_xref="UniProtKB/TrEMBL:O50434"
/inference="protein motif:PROSITE:PS00105"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43934.1"
/translation="MSASLPVFPWDTLADAKALAGAHPDGIVDLSVGTPVDPVAPLIQ
EALAAASAAPGYPATAGTARLRESVVAALARRYGITRLTEAAVLPVIGTKELIAWLPT
LLGLGGADLVVVPELAYPTYDVGARLAGTRVLRADALTQLGPQSPALLYLNSPSNPTG
RVLGVDHLRKVVEWARGRGVLVVSDECYLGLGWDAEPVSVLHPSVCDGDHTGLLAVHS
LSKSSSLAGYRAGFVVGDLEIVAELLAVRKHAGMMVPAPVQAAMVAALDDDAHERQQR
ERYAQRRAALLPALGSAGFAVDYSDAGLYLWATRGEPCRDSAAWLAQRGILVAPGDFY
GPGGAQHVRVALTATDERVAAAVGRLTC"
gene complement(1310480..1313299)
/locus_tag="Rv1179c"
CDS complement(1310480..1313299)
/codon_start=1
/transl_table=11
/locus_tag="Rv1179c"
/product="Unknown protein"
/note="Rv1179c, MTV005.15c, len: 939 aa. Unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1179c"
/db_xref="EnsemblGenomes-Tr:CCP43935"
/db_xref="GOA:O50435"
/db_xref="InterPro:IPR006935"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O50435"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43935.1"
/translation="MDPHRDLESRAFAGNWRVYQQQALDAFDADVAAGDNRAYLVLPP
GAGKTMIGLEAARRLGRRSLVLVPNTAVQAQWAAAWDNSFPSSDRSASKCGTERGLAS
AMNVLTYQSLAVIDAETDSTVRREVLRNRDQQALLDLLHPNGRAVIERAATLGPWTLV
LDECHHLLATWGALVSALASVLGAQTALIGLTATPATELTAWQHTLHDELFGTADFVI
PTPALVREGDLAPYQELVYLTQPTPEEQAWIGTHRARFADLMLALIDQKVGSMSLAAW
LHTRIVDRATREGNQIAWSTFERAEPDLACSGLRFAYDGLIPLPDGVRLREQHRIAPD
AQDWVNVLTDFSVGHLQQSADPRDAHALTAIKRVLPGLGYRLTSRGVRVATSPVDRLC
ALSESKIAATAHILDTEDAVLGARLRALVLCDFESMTGALPTSLKGAPVSEQSGSAQL
VAAMLAASDHRRRTPLHALLVTGQTFACPAAIEDDLIAFCAERGALVTAEPLDAHPSL
RVMRGTGGFTPRTWVALATEYFLAGRARVLVGTRSLLGEGWDCAAVNVNIDLTSATTQ
AAITQMRGRAIRNDPSDGHKVADNWSVCCIATEHPRGDADYLRLVRKHDGYYAATPQG
LIESGVTHCDPSLSPYGPPVTDTHAITARALQRVAERAQARSWWRIGEPYEGVDVATI
RVRSRQPLGVAAPRIPASALTPPVPGQFSPVRLARGAVAAVSVVGASTATAVASANLG
MLAGAGTAGAIVAAGVGLVATAAAAESRRLDHAPNALEQLAAVVADALYAAGGAQRGS
AALRLASDPEGWIRCQLDGVPTEQSLRFTAALDELLAPLAEPRYLIGRKILTPPARPV
ARRLFAVRAVVGLSLPGTVAWHAVPRWFARNKDRRQHLAQAWRKHIGPPRQLPADSPQ
GQAILDLFRGDNPLSVTTQLRTTWR"
gene 1313725..1315191
/gene="pks3"
/locus_tag="Rv1180"
CDS 1313725..1315191
/codon_start=1
/transl_table=11
/gene="pks3"
/locus_tag="Rv1180"
/product="Probable polyketide beta-ketoacyl synthase Pks3"
/note="Rv1180, (MTV005.16), len: 488 aa. Probable
polyketide beta-ketoacyl synthase, equivalent to a
predicted homologous protein from Mycobacterium smegmatis
(see citation below), and similar to the N-terminus of
many polyketide synthases e.g. MCAS_MYCBO|Q02251
mycocerosic acid synthase from Mycobacterium bovis (2110
aa), FASTA scores: opt: 2115, E(): 0, (66.5% identity in
472 aa overlap). Also similar to, and same length as
P96284|Z83858|MTCY24G1.02 M. tuberculosis (496 aa), FASTA
scores: opt: 1424, E(): 0, (50.9% identity in 444 aa
overlap). Contains possible signal sequence and PS00013
Prokaryotic membrane lipoprotein lipid attachment
site,also PS00606 Beta-ketoacyl synthases active site.
Belongs to the beta-ketoacyl-ACP synthases family.
Alternative nucleotide at position 1315191 (a->C;
Stop489Y) has been observed. Rv1180/Rv1181 fusion has been
called msl3."
/db_xref="EnsemblGenomes-Gn:Rv1180"
/db_xref="EnsemblGenomes-Tr:CCP43936"
/db_xref="GOA:A0A089QRB9"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:A0A089QRB9"
/inference="protein motif:PROSITE:PS00013"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43936.1"
/translation="MRTATATSVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPA
DRWDANVYYDPEPGVPGRSVSRWGAFLDDVGGFDCDFFGLTEREATAIDPQHRLLLEV
SWEAIEHAGVDPATLAESQTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGR
VAYTLGLHGPAVTVDTACSSGLTAVHQACRSLDDGESDLALAGGVVVTLEPRKSVSGS
LQGMLSPTGRCHAFDEAADGFVSGEGCVVLLLKRLPDAVRDGDRVLAIVRGTAANQDG
RTVNIAAPSAQAQIAVYQQALAAAGVEASTVGMVEAHGTGTPVGDPVEYASLAAVYGT
EGPCALTSVKTNFGHLQSASGPLGLMKTILALRHGVVPQNLHFCRLPDQLAEIDTELF
VPQANTSWPDNTGQPRRAAVSSYGMSGTNVHAILEQAPVSEPAASGPELTPEAGGLAL
FPVSATSAEQLHVTAARLADWVDQNGNAGSRVSMRDLG"
gene 1315234..1319982
/gene="pks4"
/locus_tag="Rv1181"
CDS 1315234..1319982
/codon_start=1
/transl_table=11
/gene="pks4"
/locus_tag="Rv1181"
/product="Probable polyketide beta-ketoacyl synthase Pks4"
/note="Rv1181, (MTV005.17), len: 1582 aa. Probable
pks4,polyketide synthase, similar to many e.g.
MCAS_MYCBO|Q02251 mycocerosic acid synthase from
Mycobacterium bovis (2110 aa), FASTA scores: opt: 3518,
E(): 0, (59.7% identity in 1614 aa overlap). Note that
this similarity extends upstream of the first initiation
codon into the upstream MTV005.16; the stop codon at the
end of MTV005.16 is present in at least 4 independent
clones (BAC, cosmid and pUC) from the genome (however an
alternative nucleotide at position 1315191 (a->C;
Stop489Y) has also been observed). The two CDS's may
represent separate modules of the polyketide synthase.
Rv1180/Rv1181 fusion has been called msl3."
/db_xref="EnsemblGenomes-Gn:Rv1181"
/db_xref="EnsemblGenomes-Tr:CCP43937"
/db_xref="GOA:A0A089QRB9"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:A0A089QRB9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43937.1"
/translation="MTASSFDELSAALRDVAGDQIPYQPAVGHDDRGPVWVFSGQGSQ
WPGMGTELLVAEPVFAATVAAMEPVIARESGFSVTEAMSAPQTVSGIDRVQPTIFAVQ
VALAAALKSYGVRPGAIIGHSLGEAAAAVVAGALSLHDGLRVICRRSRLMSRIAGSGA
MASVELPGQQVLSELAIRGISDVVLSVVASPTSTVVGGATQSIRDLVAAWEQQDVLAR
EVAVDVASHTPQVDPILDELLEVLAEVDPTAPEIPYYSATLWDPRERPSFTGEYWVEN
LRYTVRFAAAVQAALKDGYRVFGELAPHPLLTYAVEQNAASLDMPIATLAAMRRGEQL
PFGLRGFVADVHNAGAKVDFSVQYPDGRLVDAPLPSWTHRTLMLSREDSHRSHTGAVQ
AVHPLLGAHVHLLEEPERHVWQAGVGTGAHPWLGDHRIHNVAAFPGAAYCEMALAAAR
TTLGELSEVRDIKFEQTLLLDEQTVVSSAATIAAPGILQFAVESHQEGEPARRASAML
HALEEMPQPPGYDTNALTAAHESSMSGEELRKMFNSLGIQYGPAFSGLVAVHTARGDV
TTVLAEVALPGAIRSQQSAYASHPALLDACFQSVLVHPEVQKATVGGLMLPVGVRRLR
NYHSTRSAHYCLARVTSSSRAGECEADLDVFDQAGTVLLTVEGLRLAAGISEHERANR
VFDERLLTIEWERGELPEVPQIDAGSWLLLSASEADPLTAQLADALNAVGAQSTSVAS
ASDVAQLRSLLGGRLTGVVVVTGPPTGGLTQCGRDYVSQLVGIARELAELPGEPPRLF
VVTRSAASVLPSDLANLEQAGLRGLMRVIDSEHPHLGATAIDVDNDETVAALVASQLQ
SGSQEDETAWRNGIWYTARLRPGPLRPAERRTAVVEYRRDGMRLQIRTPGDLESLEFV
TFDRVAPGPGEIEVAVTASSVNFADVLVAFGRYPTFEGYRQQLGIDFAGVVTAVGPDV
TEHRIGDHVGGMSANGCWSTFVRCDARLAVTLPPELPVAAAAAVPTASATAWYALHDL
ARICSDDKVLIHSGTGGVGQAAIAIARAAGCEIFATAGSAQRRQLLHDMGVEHVYDSR
STEFAEQIRGDTDGYGVDVVLNSLPGAAQRAGIELLAFGGRFVEIGKRDIYGDTRLGL
FPFRRNLSLYAVDLALLTHSHPHTVRRLLKTVYQHTVEGTLPVPQTTHYPIHDAAVAI
RLVGGAGHTGKVVLDVPRTGEGVAVVPPEQVRTSRPDGAYLVTGGLGGLGLFLAGELA
AAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGDIADAATAHRVVAVATASGL
PVRGVLHAAAVVEDATLANVTDELIDRCWAPKVHGAWNIHRATAAQPLEWFCLFSSAA
ALVGSPGQGAYAAANSWLDAFAHWRRAQGLPATSIAWGAWAEIGRATALAEGTGAAIA
PAEGARAFQTLLRYGRAYSGYAPIMGTPWLTAFAQRSRFAEAFHATGQNQPATGKFLA
ELGSLPREEWPRTVRRLVSDQISLLLRRTIDPDRPLSDYGLDSLGNLELRTRIETETG
IRVSPTKITTVRGLAEHVCDELAAAQSAPV"
gene 1320035..1321453
/gene="papA3"
/locus_tag="Rv1182"
CDS 1320035..1321453
/codon_start=1
/transl_table=11
/gene="papA3"
/locus_tag="Rv1182"
/product="Probable conserved polyketide synthase
associated protein PapA3"
/note="Rv1182, (MTV005.18), len: 472 aa. Probable
papA3,conserved polyketide synthase (PKS) associated
protein,similar to other Mycobacterial hypothetical
proteins e.g. Q49618|U00010 B1170_C1_180 from
Mycobacterium leprae (471 aa), FASTA scores: opt: 2526,
E(): 0, (75.6% identity in 471 aa overlap). Similar to
other Mycobacterium tuberculosis hypothetical papA
proteins; Rv3824c, Rv3820c,Rv1528c."
/db_xref="EnsemblGenomes-Gn:Rv1182"
/db_xref="EnsemblGenomes-Tr:CCP43938"
/db_xref="GOA:P9WIK5"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WIK5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43938.1"
/translation="MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVP
VSYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYRSW
FQYNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREIVQNTPDPLQWGCFRFGIVQG
CDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHAPLELPPAGSYDDFCRRQHT
FSSTLTVESPQVRAWTKFAEGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQF
ESVCTAAGARFIGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIP
ITVPIAGSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMPRPNFPVVNFLDAG
AAPLSVLLTAELTGTNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIARESVAR
YLATLKSVFQRVAESGQQQNVA"
gene 1321520..1324528
/gene="mmpL10"
/locus_tag="Rv1183"
CDS 1321520..1324528
/codon_start=1
/transl_table=11
/gene="mmpL10"
/locus_tag="Rv1183"
/product="Probable conserved transmembrane transport
protein MmpL10"
/note="Rv1183, (MTV005.19), len: 1002 aa. Probable
mmpL10,conserved transmembrane transport protein (see
Tekaia et al., 1999), member of RND superfamily, similar
to many Mycobacterial hypothetical membrane proteins e.g.
Q49619|U00010 from Mycobacterium leprae (1008 aa), FASTA
scores: opt: 4545, E(): 0, (70.6% identity in 978 aa
overlap); etc. Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv1183"
/db_xref="EnsemblGenomes-Tr:CCP43939"
/db_xref="GOA:P9WJU1"
/db_xref="InterPro:IPR004707"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJU1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43939.1"
/translation="MVGCWVALALVLPMAVPSLAEMAQRHPVAVLPADAPSSVAVRQM
AEAFHESGSENILVVLLTDEKGLGAADENVYHTLVDRLRNDAKDVVMLQDFLTTPPLR
EVLGSKDGKAWILPIGLAGDLGTPKSYHAYTDVERIVKRTVAGTTLTANVTGPAATVA
DLTDAGARDRASIELAIAVMLLVILMVIYRNPVTMLLPLVTIGASLMTAQALVAGVSL
VGGLAVSNQAIVLLSAMIAGAGTDYAVFLISRYHEYVRLGEHPERAVQRAMMSVGKVI
AASAATVGITFLGMRFAKLGVFSTVGPALAIGIAVSFLAAVTLLPAILVLASPRGWVA
PRGERMATFWRRAGTRIVRRPKAYLGASLIGLVALASCASLAHFNYDDRKQLPPSDPS
SVGYAAMEHHFSVNQTIPEYLIIHSAHDLRTPRGLADLEQLAQRVSQIPGVAMVRGVT
RPNGETLEQARATYQAGQVGNRLGGASRMIDERTGDLNRLASGANLLADNLGDVRGQV
SRAVAGVRSLVDALAYIQNQFGGNKTFNEIDNAARLVSNIHALGDALQVNFDGIANSF
DWLDSVVAALDTSPVCDSNPMCGNARVQFHKLQTARDNGTLDKVVGLARQLQSTRSPQ
TVSAVVNDLGRSLNSVVRSLKSLGLDNPDAARARLISMQNGANDLASAGRQVADGVQM
LVDQTKNMGIGLNQASAFLMAMGNDASQPSMAGFNVPPQVLKSEEFKKVAQAFISPDG
HTVRYFIQTDLNPFSTAAMDQVNTIIDTAKGAQPNTSLADASISMSGYPVMLRDIRDY
YERDMRLIVAVTVVVVILILMALLRAIVAPLYLVGSVVISYMSAIGLGVVVFQVFLGQ
ELHWSVPGLAFVVLVAVGADYNMLLASRLRDESALGVRSSVIRTVRCTGGVITAAGLI
FAASMSGLLFSSIGTVVQGGFIIGVGILIDTFVVRTITVPAMATLLGRASWWPGHPWQ
RCAPEEGQMSARMSARTKTVFQAVADGSKR"
gene complement(1324532..1325611)
/locus_tag="Rv1184c"
CDS complement(1324532..1325611)
/codon_start=1
/transl_table=11
/locus_tag="Rv1184c"
/product="Possible exported protein"
/note="Rv1184c, (MTV005.20c), len: 359 aa. Possible
exported protein with potential N-terminal signal
sequence. Similar to several Mycobacterial hypothetical
proteins e.g. Q49633|U00010 Protein B1170_F3_112 from M.
leprae (391 aa),FASTA scores: opt: 1422, E(): 0, (62.7%
identity in 338 aa overlap). Also similar to Rv3822,
Rv3539, Rv1430, Rv0151c,etc. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004). Predicted to be an outer membrane protein (See Song
et al., 2008). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv1184c"
/db_xref="EnsemblGenomes-Tr:CCP43940"
/db_xref="GOA:O50440"
/db_xref="InterPro:IPR013228"
/db_xref="UniProtKB/Swiss-Prot:O50440"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43940.1"
/translation="MKRVIAGAFAVWLVGWAGGFGTAIAASEPAYPWAPGPPPSPSPV
GDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAGAAFSWWPTMLL
PPGSHQDNMTVGVAVKDGTNSLDNAIHHGTDPAAAVGLSQGSLVLDQEQARLANDPTA
PAPDKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVV
TAYDGFSDFPDRPDNLLAVANAAIGAAIAHTPIGFTGPGDVPPQNIRTTVNSRGATTT
TYLVPVNHLPLTLPLRYLGMSDAEVDQIDSVLQPQIDAAYARNDNWFTRPVSVDPVRG
LDPLTAPGSIVEGARGLLGSPAFGG"
gene complement(1325776..1327512)
/gene="fadD21"
/locus_tag="Rv1185c"
CDS complement(1325776..1327512)
/codon_start=1
/transl_table=11
/gene="fadD21"
/locus_tag="Rv1185c"
/product="Probable fatty-acid-AMP ligase FadD21
(fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)"
/note="Rv1185c, (MTV005.21c), len: 578 aa. Probable
fadD21,fatty-acid-AMP synthetase, highly similar to
several from Mycobacteria e.g. NP_301895.1|NC_002677
possible acyl-CoA synthase from Mycobacterium leprae (579
aa); P71495|U75685 acyl-CoA synthase from Mycobacterium
bovis (582 aa), FASTA scores: opt: 2388, E(): 0, (61.8%
identity in 579 aa overlap); etc. Seems to belong to the
ATP-dependent AMP-binding enzyme family. Nucleotide
position 1327402 in the genome sequence has been
corrected, T:C resulting in E37E."
/db_xref="EnsemblGenomes-Gn:Rv1185c"
/db_xref="EnsemblGenomes-Tr:CCP43941"
/db_xref="GOA:P9WQ49"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43941.1"
/translation="MSDSSVLSLLRERAGLQPDDAAFTYIDYEQDWAGITETLTWSEV
FRRTRIVAHEVRRHCTTGDRAVILAPQGLAYIAAFLGSMQAGAIAVPLSVPQIGSHDE
RVSAVLADASPSVILTTSAVAEAVAEHIHRPNTNNVGPIIEIDSLDLTGNSPSFRVKD
LPSAAYLQYTSGSTRAPAGVMISHRNLQANFQQLMSNYFGDRNGVAPPDTTIVSWLPF
YHDMGLVLGIIAPILGGYRSELTSPLAFLQRPARWLHSLANGSPSWSAAPNFAFELAV
RKTTDADIEGLDLGNVLGITSGAERVHPNTLSRFCNRFAPYNFREDMIRPSYGLAEAT
LYVASRNSGDKPEVVYFEPDKLSTGSANRCEPKTGTPLLSYGMPTSPTVRIVDPDTCI
ECPAGTIGEIWVKGDNVAEGYWNKPDETRHTFGAMLVHPSAGTPDGSWLRTGDLGFLS
EDEMFIVGRMKDMLIVYGRNHYPEDIESTVQEITGGRVAAISVPVDHTEKLVTVIELK
LLGDSAGEAMDELDVIKNNVTAAISRSHGLNVADLVLVPPGSIPTTTSGKIRRAACVE
QYRLQQFTRLDG"
gene complement(1327689..1329305)
/locus_tag="Rv1186c"
CDS complement(1327689..1329305)
/codon_start=1
/transl_table=11
/locus_tag="Rv1186c"
/product="Conserved protein"
/note="Rv1186c, (MTV005.22c), len: 538 aa. Conserved
protein, similar to AL117385|SC5G9.24 hypothetical protein
from Streptomyces coelicolor (555 aa), FASTA scores: opt:
485, E(): 2.3e-23, (32.6% identity in 568 aa overlap).
Contains helix turn helix motif from aa 488-509 (+2.81
SD)."
/db_xref="EnsemblGenomes-Gn:Rv1186c"
/db_xref="EnsemblGenomes-Tr:CCP43942"
/db_xref="GOA:O50442"
/db_xref="InterPro:IPR025736"
/db_xref="InterPro:IPR042070"
/db_xref="UniProtKB/TrEMBL:O50442"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43942.1"
/translation="MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSDDV
RLGLAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPSDSVVAGAVRAGS
AVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLAQSLADRIHGMISIED
AQSHVLAYSASNDEADELRRLSILGRAGPPEHLQWIGQWGIFDALRPGREVVRVAERP
ELGLRPRLAIGIHQPGVGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMS
RLATQPNTHALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRD
TAVRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTISALRA
ELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPILGQVTSLAEARTTVLLDEI
VTLVGTDQRLVDPRIRDLGAQDPVLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIR
RIEQLLSTSLGDPDVRLLFSLGLRAMERTA"
gene 1329390..1331021
/gene="rocA"
/locus_tag="Rv1187"
CDS 1329390..1331021
/codon_start=1
/transl_table=11
/gene="rocA"
/locus_tag="Rv1187"
/product="Probable pyrroline-5-carboxylate dehydrogenase
RocA"
/note="Rv1187, (MTV005.23), len: 543 aa. Probable
rocA,pyrroline-5-carboxylate dehydrogenase, similar to
many e.g. PUT2_HUMAN|P30038 human
delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa),
FASTA scores: opt: 1596, E():0,(46.0% identity in 531 aa
overlap). Also similar to other Mycobacterium tuberculosis
hypothetical dehydrogenases e.g. Rv0768, Rv2858c, etc.
Contains PS00687 Aldehyde dehydrogenases glutamic acid
active site and PS00070 Aldehyde dehydrogenases cysteine
active site."
/db_xref="EnsemblGenomes-Gn:Rv1187"
/db_xref="EnsemblGenomes-Tr:CCP43943"
/db_xref="GOA:O50443"
/db_xref="InterPro:IPR005931"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016160"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="PDB:4IDM"
/db_xref="PDB:4IDS"
/db_xref="PDB:4IHI"
/db_xref="PDB:4JDC"
/db_xref="PDB:4LEM"
/db_xref="PDB:4NS3"
/db_xref="UniProtKB/TrEMBL:O50443"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43943.1"
/translation="MDAITQVPVPANEPVHDYAPKSPERTRLRTELASLADHPIDLPH
VIGGRHRMGDGERIDVVQPHRHAARLGTLTNATHADAAAAVEAAMSAKSDWAALPFDE
RAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFNVAFARQIL
EQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPALMGNTVIWKPSITQT
LAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQW
VGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAF
IAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVT
VAVGGEYDDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVIDT
GSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTND
KAGSPLNLLRWTSARSIKETFVAATDHIYPHMAVD"
gene 1331021..1332010
/locus_tag="Rv1188"
CDS 1331021..1332010
/codon_start=1
/transl_table=11
/locus_tag="Rv1188"
/product="Probable proline dehydrogenase"
/note="Rv1188, (MTV005.24), len: 329 aa. Possible
putA,proline dehydrogenase, similar to part of
Q52711|X78346 proline dehydrogenase from Rhodobacter
capsulatus (1127 aa), FASTA scores: opt: 194, E():
1.5e-07, (31.2% identity in 349 aa overlap). Also similar
to two Bacillus subtilis proline dehydrohenases
E1184363|Z99120 (302 aa), FASTA scores: opt: 509, E(): 0,
(37.1% identity in 313 aa overlap); and E1182272|Z99105
(303 aa), FASTA scores: opt: 513, E(): 0, (32.5% identity
in 311 aa overlap). Highly similar to AL035569|SC8D9.31
Streptomyces coelicolor (308 aa), FASTA scores: opt: 984,
E(): 0, (50.0% identity in 312 aa overlap). Nucleotide
position 1331696 in the genome sequence has been
corrected, A:C resulting in R226R."
/db_xref="EnsemblGenomes-Gn:Rv1188"
/db_xref="EnsemblGenomes-Tr:CCP43944"
/db_xref="GOA:O50444"
/db_xref="InterPro:IPR002872"
/db_xref="InterPro:IPR008219"
/db_xref="InterPro:IPR015659"
/db_xref="InterPro:IPR029041"
/db_xref="UniProtKB/TrEMBL:O50444"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43944.1"
/translation="MAGWFAHTLRPAMLAAGRSDRLGRIVERSPLTRGVVRRFVPGDT
LDDVVDIVTALRDSGRYLSIDYLGENVTDADDAAAAVRAYLGLLDVLGRRGDIACDGV
RPLEVSLKLSALGQALDRDGQKIALDNARAICERAERVGAWVTVDAEDHTTTDSTLSI
SGDLRVDFPWLGTVVQAYLRRTLADCAELAAVGARVRLCKGAYDEPASVAYRDAAQVT
DSYLRCLRVLTAGRGYPMVATHDPVIIAAVPGITRESGRSQGDFEYQMLYGVRDDEQR
RLTGAGNHVRVYVPFGTRWYGYFLRRLAERPANLAFFLRALTDRRRARGCAER"
gene 1332092..1332964
/gene="sigI"
/locus_tag="Rv1189"
CDS 1332092..1332964
/codon_start=1
/transl_table=11
/gene="sigI"
/locus_tag="Rv1189"
/product="Possible alternative RNA polymerase sigma factor
SigI"
/note="Rv1189, (MTV005.25-MTCI364.01), len: 290 aa.
Possible sigI, alternative RNA polymerase sigma factor
(see Gomez et al., 1997; Chen et al., 2000), similar to
several e.g. O05767|U87307 extracytoplasmic function
alternative sigma factor (sigE) from Mycobacterium
smegmatis (204 aa),FASTA scores: opt: 239, E(): 1.3e-09,
(32.9% identity in 167 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1189"
/db_xref="EnsemblGenomes-Tr:CCP43945"
/db_xref="GOA:P9WGH3"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WGH3"
/protein_id="CCP43945.1"
/translation="MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLL
RAPVGDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDPADRV
TLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQQIATTIGSQASTCRQLAHRARR
KINESRIAASVEPAQHRVVTRAFIEACSNGDLDTLLEVLDPGVAGEIDARKGVVVVGA
DRVGPTILRHWSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQ
PSTLDPLRAELGGG"
gene 1332980..1333858
/locus_tag="Rv1190"
CDS 1332980..1333858
/codon_start=1
/transl_table=11
/locus_tag="Rv1190"
/product="Conserved hypothetical protein"
/note="Rv1190, (MTCI364.02), len: 292 aa. Conserved
hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600
hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta
scores: opt: 331, E(): 1.4e-15, (29.0% identity in 272 aa
overlap), also YU14_MYCTU|Q50670 putative haloalkane
dehalogenase (300 aa), FASTA scores: opt: 239, E():
2.2e-09, (29.9% identity in 298 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1190"
/db_xref="EnsemblGenomes-Tr:CCP43946"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O86348"
/protein_id="CCP43946.1"
/translation="MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPA
VLFVHVGSWSFVWRDVLLRLANDFRCVAIDAPGCGLSDRLSTPPTLAQAADAITSVID
ALQLRDLTLVAHDLGGPAGFLAAARRGDRVAALAAVNCFAWRPTGPLFRGMLAAMGSA
PVRELDAAINALARATSTRFGAGRHWSRADRAAFRAGIDAPARRAWHAYFRDARRAHA
LYTDVDAALRGGLADRPLLTIFGQFNDPLRFQPRWKELFPTARQLQVRRGNHFPMCDD
PDLVAGALTSFVQRST"
gene 1333931..1334845
/locus_tag="Rv1191"
CDS 1333931..1334845
/codon_start=1
/transl_table=11
/locus_tag="Rv1191"
/product="Conserved protein"
/note="Rv1191, (MTCI364.03), len: 304 aa. Conserved
protein, similar to Q54528 RDMC from Streptomyces
purpurascens (298 aa), FASTA scores: opt: 196, E():
1.5e-05, (27.5% identity in 269 aa overlap);
Rv0134|MTCI5.08 (300 aa), FASTA scores: opt: 197, E():
6.6e-06, (26.4% identity in 299 aa overlap), some
similarity to PIP_NEIGO|P42786 proline iminopeptidase (310
aa), FASTA scores: opt: 196, E(): 1.3e-05, (32.2% identity
in 152 aa overlap). Contains PS00044 Bacterial regulatory
proteins, lysR family signature."
/db_xref="EnsemblGenomes-Gn:Rv1191"
/db_xref="EnsemblGenomes-Tr:CCP43947"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O05293"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43947.1"
/translation="MAVAIARPKLEGNIAVGEDRRIGFAEFGAPQGRAVFWLHGTPGA
RRQIPTEARVYAEHHNIRLIGVDRPGIGASTPHQYETILAFADDLRTIADTLGIDKMA
VVGLSGGGPYTLACAAGLPDRVVAAGVLGGVAPTRGPDAISGGLMRLGSAVAPLLQVG
GTPLRLGASLLIRAARPVASPALDLYGLLSPRADRHLLARPEFKAMFLDDLLNGSRKQ
LAAPFADVIAFARDWGFRLDEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLP
GESHLAGLGRGEEILSTLMQIWDRDLRK"
gene 1334927..1335754
/locus_tag="Rv1192"
CDS 1334927..1335754
/codon_start=1
/transl_table=11
/locus_tag="Rv1192"
/product="Unknown protein"
/note="Rv1192, (MTCI364.04), len: 275 aa. Unknown
protein,contains PS00120 lipases, serine active site."
/db_xref="EnsemblGenomes-Gn:Rv1192"
/db_xref="EnsemblGenomes-Tr:CCP43948"
/db_xref="GOA:O05294"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O05294"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43948.1"
/translation="MLLPVLEPADRPCDAPGWFLYLTDIPRAGVEYGQLLAVLPLQRM
LPAGDGHPVLVLPGLLAGDGSTWILRRILRRLGYAAYGWGLGRNIGPTAKAVSGMRDL
LDKLHSRYHTPVSLIGWSLGGIFARGLARDHPSAVRQVITLGSPFGMRDTCETRSAWS
FNRYAHLHTERHELPLEMESEPLPVPTTAIYSRCDGMVAWQTCMNSPSERAENIAVRS
SHIGYGHNPPVVWAIADRLAQPQGAWAPFRPPKVLSPLFPRPDTPAEAVSTPQTRPA"
gene 1335794..1337215
/gene="fadD36"
/locus_tag="Rv1193"
CDS 1335794..1337215
/codon_start=1
/transl_table=11
/gene="fadD36"
/locus_tag="Rv1193"
/product="Probable fatty-acid-CoA ligase FadD36
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv1193, (MTCI364.05), len: 473 aa. Probable
fadD36,fatty-acid-CoA synthetase, highly similar to
Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium
leprae (476 aa),FASTA scores: opt: 2594, E(): 0, (81.3%
identity in 476 aa overlap). Also highly similar to others
e.g. CAB86109.1|AL163003 putative fatty acid synthase from
Streptomyces coelicolor (485 aa); LCFA_ECOLI|P29212
long-chain-fatty-acid--CoA ligase from Escherichia coli
(561 aa), FASTA scores: opt: 605, E(): 8.4e-30, (33.0%
identity in 364 aa overlap); etc. Contains PS00455
Putative AMP-binding domain signature. Belongs to the
ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv1193"
/db_xref="EnsemblGenomes-Tr:CCP43949"
/db_xref="GOA:O05295"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O05295"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43949.1"
/translation="MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVA
GAHRVAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWLGPLP
DDPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDA
LAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAH
GTLFFGVPTVWSRVAADQAAAGALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYG
ASESLITLSTRADGERRPGWVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLF
DGYLNQPDATAAAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIE
TVLLGHPDVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHKRPREV
RIVDALPRNALGKVLKKQLLSEG"
gene complement(1337248..1338513)
/locus_tag="Rv1194c"
CDS complement(1337248..1338513)
/codon_start=1
/transl_table=11
/locus_tag="Rv1194c"
/product="Conserved protein"
/note="Rv1194c, (MTCI364.06c), len: 421 aa. Conserved
protein, highly similar to Q50018 possible transcriptional
activator from Mycobacterium leprae (517 aa), FASTA
scores: opt: 1960, E(): 0, (69.8% identity in 421 aa
overlap). Also similar to Mycobacterium tuberculosis
Rv2370c|MTCY27.10,(62.0% identity in 421 aa overlap) and
Rv1453|MTCY493.01c."
/db_xref="EnsemblGenomes-Gn:Rv1194c"
/db_xref="EnsemblGenomes-Tr:CCP43950"
/db_xref="GOA:O05296"
/db_xref="InterPro:IPR025736"
/db_xref="InterPro:IPR041522"
/db_xref="InterPro:IPR042070"
/db_xref="UniProtKB/TrEMBL:O05296"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43950.1"
/translation="MAWQQPSPRIRELIREGARIALNPSPEWIEELDRATIAANPAIA
NDPVLAKVVQTANRANLVYWAAANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFN
IYRTGEHIGWRFWMGIAFELTSDPQELRELLDVSARSVNDFIEATLTGIAAQVQSEHD
ELTRSTHAERLEVVGLILDGAPISPERAEAKLGYPLSRAHTAAIIWSDELDGDHSYLD
RAADLFCHAVGSTRPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAPGARIAIGTTA
NGVEGFRRSHLEALITQRTLSRLRSTQRVAFFADVKMVALISQNPDAASEFITSTLGD
LESASPDLQTALLTFINEQCNASRAAKRLHTHRNTFLRRLESAQRLLPRPLDHTSVHV
AVALEALQWRGNKAHALSSPGRRSNSVPA"
gene 1339003..1339302
/gene="PE13"
/locus_tag="Rv1195"
CDS 1339003..1339302
/codon_start=1
/transl_table=11
/gene="PE13"
/locus_tag="Rv1195"
/product="PE family protein PE13"
/note="Rv1195, (MTCI364.07), len: 99 aa. PE13, Member of
Mycobacterium tuberculosis PE family (see Brennan & Delogu
2002), e.g. Y0DP_MYCTU|Q50615 hypothetical glycine-rich
40.8 kd protein (498 aa), FASTA scores: opt: 307, E():
1.4e-12, (56.3% identity in 96 aa overlap), similar to
MTCY21C12.10c (99 aa), FASTA scores: opt:295, E():
1.9e-11,(51.5% identity in 97 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1195"
/db_xref="EnsemblGenomes-Tr:CCP43951"
/db_xref="GOA:Q79FR3"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:Q79FR3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43951.1"
/translation="MSFVMAYPEMLAAAADTLQSIGATTVASNAAAAAPTTGVVPPAA
DEVSALTAAHFAAHAAMYQSVSARAAAIHDQFVATLASSASSYAATEVANAAAAS"
gene 1339349..1340524
/gene="PPE18"
/gene_synonym="mtb39a"
/locus_tag="Rv1196"
CDS 1339349..1340524
/codon_start=1
/transl_table=11
/gene="PPE18"
/gene_synonym="mtb39a"
/locus_tag="Rv1196"
/product="PPE family protein PPE18"
/note="Rv1196, (MTCI364.08), len: 391 aa. PPE18 (alternate
gene name: mtb39a). Member of the Mycobacterium
tuberculosis PPE family of glycine-rich proteins, highly
similar to others e.g. Y07P_MYCTU|Q11031 hypothetical 40.0
kDa protein cy02b10.25c (396 aa), FASTA scores: opt:
2124,E(): 0, (85.1% identity in 397 aa overlap). Note that
expression of Rv1196 was demonstrated in lysates by
immunodetection (see Dillon et al., 1999)."
/db_xref="EnsemblGenomes-Gn:Rv1196"
/db_xref="EnsemblGenomes-Tr:CCP43952"
/db_xref="GOA:L7N675"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:L7N675"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43952.1"
/translation="MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASDLFSAAS
AFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAY
GLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAAATA
TATATLLPFEEAPEMTSAGGLLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPTQGT
TPSSKLGGLWKTVSPHRSPISNMVSMANNHMSMTNSGVSMTNTLSSMLKGFAPAAAAQ
AVQTAAQNGVRAMSSLGSSLGSSGLGGGVAANLGRAASVGSLSVPQAWAAANQAVTPA
ARALPLTSLTSAAERGPGQMLGGLPVGQMGARAGGGLSGVLRVPPRPYVMPHSPAAG"
gene 1340578..1340625
/gene="ncrMT1234"
ncRNA 1340578..1340625
/gene="ncrMT1234"
/product="Fragment of putative small regulatory RNA"
/note="ncrMT1234, fragment of putative small regulatory
RNA (See Pelly et al., 2012), cloned from M. tuberculosis
CDC1551; supported by RNA-seq in H37Rv (unpublished
data)."
/ncRNA_class="other"
gene 1340659..1340955
/gene="esxK"
/gene_synonym="ES6_3"
/gene_synonym="QILSS"
/gene_synonym="TB11.0"
/locus_tag="Rv1197"
CDS 1340659..1340955
/codon_start=1
/transl_table=11
/gene="esxK"
/gene_synonym="ES6_3"
/gene_synonym="QILSS"
/gene_synonym="TB11.0"
/locus_tag="Rv1197"
/product="ESAT-6 like protein EsxK (ESAT-6 like protein
3)"
/note="Rv1197, (MT1235, MTCI364.09), len: 98 aa.
EsxK,ESAT-6 like protein (see citation below). Member of
M. tuberculosis hypothetical QILSS protein family with
Rv1038c, etc. Almost identical to MTCY98.023c (98 aa)
(99.0% identity in 98 aa overlap) and MTCY10G2.11 (98
aa),FASTA scores: opt: 643, E(): 0, (99.0% identity in 98
aa overlap); highly similar to Q49945|U1756C from
Mycobacterium leprae (100 aa), FASTA scores: opt: 377,
E(): 8e-21, (58.3% identity in 96 aa overlap). Belongs to
the ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv1197"
/db_xref="EnsemblGenomes-Tr:CCP43953"
/db_xref="GOA:P9WNJ7"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43953.1"
/translation="MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAG
WSGMAEATSLDTMAQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS"
gene 1341006..1341290
/gene="esxL"
/gene_synonym="ES6_4"
/gene_synonym="Mtb9.9C"
/locus_tag="Rv1198"
CDS 1341006..1341290
/codon_start=1
/transl_table=11
/gene="esxL"
/gene_synonym="ES6_4"
/gene_synonym="Mtb9.9C"
/locus_tag="Rv1198"
/product="Putative ESAT-6 like protein EsxL (ESAT-6 like
protein 4)"
/note="Rv1198, (MT1236, MTCI364.10), len: 94 aa.
EsxL,ESAT-6 like protein (see citation below). Member of
the ESAT-6 family with Rv3619c, Rv1037c, etc. Almost
identical to MTCY10G2.12 (94 aa) (97.9% identity in 94 aa
overlap) and MTCY98.022c (94 aa) (94.7% identity in 94 aa
overlap). Highly similar to Q49946|U1756D Mycobacterium
leprae (95 aa), FASTA scores: opt: 403, E(): 1.1e-22,
(64.1% identity in 92 aa overlap). seems to belong to the
ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv1198"
/db_xref="EnsemblGenomes-Tr:CCP43954"
/db_xref="GOA:P9WNJ5"
/db_xref="InterPro:IPR009416"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43954.1"
/translation="MTINYQFGDVDAHGAMIRAQAGLLEAEHQAIIRDVLTASDFWGG
AGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA"
gene complement(1341358..1342605)
/locus_tag="Rv1199c"
CDS complement(1341358..1342605)
/codon_start=1
/transl_table=11
/locus_tag="Rv1199c"
/product="Possible transposase"
/note="Rv1199c, (MTCI364.11c), len: 415 aa. Possible
transposase for IS1081, identical to TRA1_MYCBO|P35882
transposase for insertion sequence element (415 aa);
region identical to MTCY441.35 (100.0% identity in 261 aa
overlap); and almost identical to MTCY10G2.02c (415 aa)
(99.8% identity in 415 aa overlap). Contains PS01007
Transposases, Mutator family, signature, PS00435
Peroxidases proximal heme-ligand signature."
/db_xref="EnsemblGenomes-Gn:Rv1199c"
/db_xref="EnsemblGenomes-Tr:CCP43955"
/db_xref="GOA:P60230"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/Swiss-Prot:P60230"
/inference="protein motif:PROSITE:PS01007"
/inference="protein motif:PROSITE:PS00435"
/protein_id="CCP43955.1"
/translation="MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADAL
CGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERA
LTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGP
YTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRD
LVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRT
LLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIW
SNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRA
RAALTSTEEPAKQQTTNTPALTT"
mobile_element complement(1341361..1342789)
/mobile_element_type="insertion sequence:IS1081-2"
/note="IS1081-2, len: 1429 nt. Insertion sequence IS1081."
gene 1342942..1344219
/locus_tag="Rv1200"
CDS 1342942..1344219
/codon_start=1
/transl_table=11
/locus_tag="Rv1200"
/product="Probable conserved integral membrane transport
protein"
/note="Rv1200, (MTCI364.12), len: 425 aa. Probable
conserved integral membrane transport protein, possibly
member of major facilitator superfamily (MFS), similar to
others e.g. YHJE_ECOLI|P37643 hypothetical metabolite
transport protein from Escherichia coli (440 aa), FASTA
scores: opt: 1047, E(): 0, (39.1% identity in 427 aa
overlap); etc. Contains PS00217 Sugar transport proteins
signature 2. The transcription of this CDS seems to be
activated in macrophages (see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv1200"
/db_xref="EnsemblGenomes-Tr:CCP43956"
/db_xref="GOA:O05301"
/db_xref="InterPro:IPR004736"
/db_xref="InterPro:IPR005828"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O05301"
/inference="protein motif:PROSITE:PS00217"
/protein_id="CCP43956.1"
/translation="MKRVALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAA
VASMGTFAVAFLSRPFGAAVFGYFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIG
AAAPLILTTMRLLQGFAVGGEWAGSALLSAEYAPASKRGWYGMFTVVGGGIALVLTSL
TFLGVNYTIGESSPTFMQWGWRIPFLVSAALIAVALYVRFNIDETPVFARERADEKTR
LGPAETPIAQVLRRQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFD
SVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVMPLIDSGSPSLFAVAV
VGMYAIGGFGFGPTASFIPELFATSYRYTGSALAANLAGVAGGALPPVIAGALVATYG
SWAIGVMLAILALISLVCTYRLPETAGSALVSR"
gene complement(1344216..1345169)
/gene="dapD"
/locus_tag="Rv1201c"
CDS complement(1344216..1345169)
/codon_start=1
/transl_table=11
/gene="dapD"
/locus_tag="Rv1201c"
/product="Tetrahydrodipicolinate N-succinyltransferase
DapD"
/note="Rv1201c, (MTCI364.13c), len: 317 aa.
dapD,tetrahydrodipicolinate N-succinyltransferase. Highly
similar to Q49948|U1756F Mycobacterium leprae (317
aa),FASTA scores: opt: 1776, E(): 0, (84.9% identity in
317 aa overlap), also Q46064 ORF3 protein from
corynebacterium glutamicum (316 aa), FASTA scores: opt:
864, E(): 0, (44.1% identity in 311 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1201c"
/db_xref="EnsemblGenomes-Tr:CCP43957"
/db_xref="GOA:P9WP21"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR011004"
/db_xref="InterPro:IPR019875"
/db_xref="InterPro:IPR026586"
/db_xref="InterPro:IPR032784"
/db_xref="InterPro:IPR038361"
/db_xref="PDB:3FSX"
/db_xref="PDB:3FSY"
/db_xref="UniProtKB/Swiss-Prot:P9WP21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43957.1"
/translation="MSTVTGAAGIGLATLAADGSVLDTWFPAPELTESGTSATSRLAV
SDVPVELAALIGRDDDRRTETIAVRTVIGSLDDVAADPYDAYLRLHLLSHRLVAPHGL
NAGGLFGVLTNVVWTNHGPCAIDGFEAVRARLRRRGPVTVYGVDKFPRMVDYVVPTGV
RIADADRVRLGAHLAPGTTVMHEGFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGA
SIMGTLSGGGTHVISIGKRCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTMPDSNSV
KARELSGSSNLLFRRNSVSGAVEVLARDGQGIALNEDLHAN"
gene 1345260..1346324
/gene="dapE"
/locus_tag="Rv1202"
CDS 1345260..1346324
/codon_start=1
/transl_table=11
/gene="dapE"
/locus_tag="Rv1202"
/product="Probable succinyl-diaminopimelate desuccinylase
DapE"
/note="Rv1202, (MTCI364.14), len: 354 aa. Probable
dapE,succinyl-diaminopimelate desuccinylase, similar to
DAPE_CORGL|Q59284 succinyl-diaminopimelate desuccinylase
from Corynebacterium glutamicum (369 aa), FASTA scores:
opt: 1301, E(): 0, (55.7% identity in 359 aa
overlap),highly similar to Q49949|U1756G (400 aa), FASTA
scores: opt: 2045, E(): 0, (87.0% identity in 354 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1202"
/db_xref="EnsemblGenomes-Tr:CCP43958"
/db_xref="GOA:P9WHS9"
/db_xref="InterPro:IPR001261"
/db_xref="InterPro:IPR002933"
/db_xref="InterPro:IPR010174"
/db_xref="InterPro:IPR011650"
/db_xref="InterPro:IPR036264"
/db_xref="UniProtKB/Swiss-Prot:P9WHS9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43958.1"
/translation="MLDLRGDPIELTAALIDIPSESRKEARIADEVEAALRAQASGFE
IIRNGNAVLARTKLNRSSRVLLAGHLDTVPVAGNLPSRRENDQLHGCGAADMKSGDAV
FLHLAATLAEPTHDLTLVFYDCEEIDSAANGLGRIQRELPDWLSADVAILGEPTAGCI
EAGCQGTLRVVLSVTGTRAHSARSWLGDNAIHKLGAVLDRLAVYRARSVDIDGCTYRE
GLSAVRVAGGVAGNVIPDAASVTINYRFAPDRSVAAALQHVHDVFDGLDVQIEQTDAA
AGALPGLSEPAAKALVEAAGGQVRAKYGWTDVSRFAALGIPAVNYGPGDPNLAHCRDE
RVPVGNITAAVDLLRRYLGG"
gene complement(1346321..1346905)
/locus_tag="Rv1203c"
CDS complement(1346321..1346905)
/codon_start=1
/transl_table=11
/locus_tag="Rv1203c"
/product="Hypothetical protein"
/note="Rv1203c, (MTCI364.15c), len: 194 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1203c"
/db_xref="EnsemblGenomes-Tr:CCP43959"
/db_xref="UniProtKB/TrEMBL:O05304"
/protein_id="CCP43959.1"
/translation="MLLAYVLITKGEFGAAASMLEPAAATLERTGYSWGPLSLMLLAT
AIAQQGHIAESAKTLQRAEARHGTKSALFAPELGLARAWTRAAAQDMTGAIAAAREAA
RTAERAGQAAVALCAWHNAVRLGDIRAVDPVTRLAAEIDCTVGNILVKHARGLADGDA
AELTAVAEELAGIGMAAAAADATKAAARLGPQQR"
gene complement(1346936..1348624)
/locus_tag="Rv1204c"
CDS complement(1346936..1348624)
/codon_start=1
/transl_table=11
/locus_tag="Rv1204c"
/product="Conserved hypothetical protein"
/note="Rv1204c, (MTCI364.16c), len: 562 aa. Conserved
hypothetical protein, some similarity to Q55103 CHO-ORF2
from streptomyces SP. (642 aa), FASTA scores: opt:
215,E(): 3.6e-06, (26.4% identity in 576 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A."
/db_xref="EnsemblGenomes-Gn:Rv1204c"
/db_xref="EnsemblGenomes-Tr:CCP43960"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O05305"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP43960.1"
/translation="MRVWKHVEAAVDSPDRCGVVLVGPHGVGKTLLAQLAAEQVMSED
GRSGRARWVVGTAPGRAIPFGAFRHLISLPASGADIGRPAALLRAARSSLTGDAGDLL
LVVDDAHNLDPLSATLVYQLARAGAARLVVTVASEAEPPDAIAALWSDDLLTRVAIEP
LDRAQTAAFVESALDATLDVADADELFRRSLGNPLYLRHLIDGGGLEHVDGRWRCRDE
DRRPLSGVIDEYLCALPEPARAVVDYLAIAEPLARTDLVALVGGEQLDTLGQAEAAGA
VRVGPDSDTSEIFVGHPLYADRARAVLTAEHAHALRVSLVAQLAKHPSDHVSDQLRLS
SLAIDVPASATPAAVTDAATAAGQALRLGDVRLAERLARAALDRSDALAARLPLAYAL
GWQGRGREADAVLAAVNPAELTETELMAWAIPRAANRFWMLNEPERATAFLQTTRSRV
TEPTARSTLDALAATFAMNSGNLPRAITLATEVLSGPAADDMAVAWAASAAALSSARM
GRFGDVDRLAERASAAEHPGLLRFTVGLAQITSLLLAGDVAPAQELAKRFTDFA"
gene 1348719..1349282
/locus_tag="Rv1205"
CDS 1348719..1349282
/codon_start=1
/transl_table=11
/locus_tag="Rv1205"
/product="Conserved hypothetical protein"
/note="Rv1205, (MTCI364.17), len: 187 aa. Conserved
hypothetical protein, similar to Q49952 cosmid B1756 from
Mycobacterium leprae (187 aa), FASTA scores: opt: 865,
E(): 0, (72.4% identity in 174 aa overlap), also similar
to FAS6_RHOFA|P46378 hypothetical 21.1 kDa protein in
fasciation locus (ORF6) (198 aa), FASTA scores: opt:
368,E(): 1.3e-17, (37.4% identity in 174 aa overlap). Some
similarity to YJL055W Hypothetical protein in BTN1-PEP8
intergenic region from Saccharomyces cerevisiae and P48636
hypothetical protein in AZU 5'region from Pseudomonas
aeruginosa. The transcription of this CDS seems to be
activated specifically in host granulomas (see citation
below)."
/db_xref="EnsemblGenomes-Gn:Rv1205"
/db_xref="EnsemblGenomes-Tr:CCP43961"
/db_xref="GOA:O05306"
/db_xref="InterPro:IPR005269"
/db_xref="InterPro:IPR031100"
/db_xref="UniProtKB/Swiss-Prot:O05306"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43961.1"
/translation="MSAKIDITGDWTVAVYCAASPTHAELLELAAEVGAAIAGRGWTL
VWGGGHVSAMGAVASAARACGGWTVGVIPKMLVYRELADHDADELIVTDTMWERKQIM
EDRSDAFIVLPGGVGTLDELFDAWTDGYLGTHDKPIVMVDPWGHFDGLRAWLNGLLDT
GYVSPTAMERLVVVDNVKDALRACAPS"
gene 1349332..1351125
/gene="fadD6"
/locus_tag="Rv1206"
CDS 1349332..1351125
/codon_start=1
/transl_table=11
/gene="fadD6"
/locus_tag="Rv1206"
/product="Probable fatty-acid-CoA ligase FadD6
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv1206, (MTCI364.18), len: 597 aa. Probable
fadD6,fatty-acid-CoA synthetase, highly similar to several
e.g. NP_251583.1|NC_002516 probable very-long-chain
acyl-CoA synthetase from Pseudomonas aeruginosa (608 aa);
Q60714 mouse fatty acid transport protein fatp (646 aa),
FASTA scores: opt:712, E(): 0, (36.8% identity in 600 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop), and PS00455 Putative AMP-binding domain
signature. Belongs to the ATP-dependent AMP-binding enzyme
family."
/db_xref="EnsemblGenomes-Gn:Rv1206"
/db_xref="EnsemblGenomes-Tr:CCP43962"
/db_xref="GOA:O05307"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR030310"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O05307"
/inference="protein motif:PROSITE:PS00455"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43962.1"
/translation="MSDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPN
SKASIGTVFQDRAARYGDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVVGI
MLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAE
CGASRGRVAGDVLTVEDVERFATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASV
MTHHRWLRALAVFGGMGLRLKGSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSF
SASRFWDEVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEFT
TRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMPLAFVEYDLDTGDPLRDASGRV
RRVPDGEPGLLLSRVNRLQPFDGYTDPVASEKKLVRNAFRDGDCWFNTGDVMSPQGMG
HAAFVDRLGDTFRWKGENVATTQVEAALASDQTVEECTVYGVQIPRTGGRAGMAAITL
RAGAEFDGQALARTVYGHLPGYALPLFVRVVGSLAHTTTFKSRKVELRNQAYGADIED
PLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG"
gene 1351191..1352147
/gene="folP2"
/locus_tag="Rv1207"
CDS 1351191..1352147
/codon_start=1
/transl_table=11
/gene="folP2"
/locus_tag="Rv1207"
/product="Dihydropteroate synthase 2 FolP2 (DHPS 2)
(dihydropteroate pyrophosphorylase 2)"
/note="Rv1207, (MTCI364.19), len: 318 aa.
folP2,Dihydropteroate synthase 2, similar to many e.g.
DHPS_ECOLI|P26282 Escherichia coli (282 aa), FASTA scores:
opt: 480, E(): 1.9e-22, (34.4% identity in 270 aa
overlap). Contains PS00792 dihydropteroate synthase
signature 1,PS00793 dihydropteroate synthase signature 2."
/db_xref="EnsemblGenomes-Gn:Rv1207"
/db_xref="EnsemblGenomes-Tr:CCP43963"
/db_xref="GOA:P9WNC9"
/db_xref="InterPro:IPR000489"
/db_xref="InterPro:IPR006390"
/db_xref="InterPro:IPR011005"
/db_xref="PDB:2VP8"
/db_xref="UniProtKB/Swiss-Prot:P9WNC9"
/inference="protein motif:PROSITE:PS00792"
/inference="protein motif:PROSITE:PS00793"
/protein_id="CCP43963.1"
/translation="MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALI
MAIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTEIT
RLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDPAMPEVAAEFG
AGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAAAERAVAAGVAREKVLIDP
AHDFGKNTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETLGVDLTERLEGTLAATA
LAAAAGARMFRVHEVAATRRVLEMVASIQGVRPPTRTVRGLA"
gene 1352144..1353118
/gene="gpgS"
/locus_tag="Rv1208"
CDS 1352144..1353118
/codon_start=1
/transl_table=11
/gene="gpgS"
/locus_tag="Rv1208"
/product="Probable glucosyl-3-phosphoglycerate synthase
GpgS"
/note="Rv1208, (MTCI364.20), len: 324 aa. Probable
gpgS,glucosyl-3-phosphoglycerate synthase (See Empadinhas
et al., 2008), similar to Q49955|U1756L Mycobacterium
leprae (318 aa), FASTA scores, opt: 1621, E(): 0, (80.5%
identity in 318 aa overlap). Belongs to retaining
glycosyltransferase family 81."
/db_xref="EnsemblGenomes-Gn:Rv1208"
/db_xref="EnsemblGenomes-Tr:CCP43964"
/db_xref="GOA:P9WMW9"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="PDB:3E25"
/db_xref="PDB:3E26"
/db_xref="PDB:4DDZ"
/db_xref="PDB:4DE7"
/db_xref="PDB:4DEC"
/db_xref="PDB:4Y6N"
/db_xref="PDB:4Y6U"
/db_xref="PDB:4Y7F"
/db_xref="PDB:4Y7G"
/db_xref="PDB:4Y9X"
/db_xref="PDB:5JQQ"
/db_xref="PDB:5JQX"
/db_xref="PDB:5JT0"
/db_xref="PDB:5JUC"
/db_xref="UniProtKB/Swiss-Prot:P9WMW9"
/protein_id="CCP43964.1"
/translation="MTASELVAGDLAGGRAPGALPLDTTWHRPGWTIGELEAAKAGRT
ISVVLPALNEEATIESVIDSISPLVDGLVDELIVLDSGSTDDTEIRAIASGARVVSRE
QALPEVPVRPGKGEALWRSLAATSGDIVVFIDSDLINPHPLFVPWLVGPLLTGEGIQL
VKSFYRRPLQVSDVTSGVCATGGGRVTELVARPLLAALRPELGCVLQPLSGEYAASRE
LLTSLPFAPGYGVEIGLLIDTFDRLGLDAIAQVNLGVRAHRNRPLDELGAMSRQVIAT
LLSRCGIPDSGVGLTQFLPGGPDDSDYTRHTWPVSLVDRPPMKVMRPR"
gene 1353157..1353525
/locus_tag="Rv1209"
CDS 1353157..1353525
/codon_start=1
/transl_table=11
/locus_tag="Rv1209"
/product="Conserved protein"
/note="Rv1209, (MTCI364.21), len: 122 aa. Conserved
protein, containing a hydrophobic N-terminus. Similar to
Q49956|U1756M hypothetical protein from Mycobacterium
leprae (114 aa), FASTA scores: opt: 524, E():
8.9e-29,(78.6% identity in 112 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1209"
/db_xref="EnsemblGenomes-Tr:CCP43965"
/db_xref="GOA:O05310"
/db_xref="InterPro:IPR019933"
/db_xref="UniProtKB/TrEMBL:O05310"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43965.1"
/translation="MALVLVYLVVLVLVAIVLFAAASLLFGRGEQLPPLPRATTATTL
PAFGVTRADVDAVKFTQVLRGYKTSEVDWVLERLGRELEALRSQLGAIHASSEDAEAE
SDASNPSRGETVVHYRSDPA"
gene 1353522..1354136
/gene="tagA"
/locus_tag="Rv1210"
CDS 1353522..1354136
/codon_start=1
/transl_table=11
/gene="tagA"
/locus_tag="Rv1210"
/product="Probable DNA-3-methyladenine glycosylase I TagA
(tag I) (3-methyladenine-DNA glycosylase I, constitutive)
(DNA-3-methyladenine glycosidase I)"
/note="Rv1210, (MTCI364.22), len: 204 aa. Probable
tagA,DNA-3-methyladenine glycosidase I (see citation
below),similar to several e.g. 3MG1_ECOLI|P05100
DNA-3-methyladenine glycosidase I from Escherichia coli
(187 aa), FASTA scores: opt: 530, E(): 1.3e-27, (44.2%
identity in 190 aa overlap); similar to Q49957
Mycobacterium leprae cosmid B1756 (192 aa), FASTA scores:
opt: 1042, E(): 0, (80.2% identity in 192 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1210"
/db_xref="EnsemblGenomes-Tr:CCP43966"
/db_xref="GOA:O05311"
/db_xref="InterPro:IPR004597"
/db_xref="InterPro:IPR005019"
/db_xref="InterPro:IPR011257"
/db_xref="UniProtKB/TrEMBL:O05311"
/protein_id="CCP43966.1"
/translation="MSGDGLVRCPWAEVRPGPDAQLYRDYHDNEWGRPLYGRVALFER
MSLEAFQSGLSWLIILRKRENFRRAFSGFDIDKIARYTDTDVRRLLADDGIVRNRAKI
EATIANARAAADLGSSEDLSELLWSFAPPPRPRPVDGSEIPSVSTESKAMSRELKRRG
FRFVGPTTAYALMQATGMVDDHIQACWVPTERPFDQPGCPMAAR"
gene 1354243..1354470
/locus_tag="Rv1211"
CDS 1354243..1354470
/codon_start=1
/transl_table=11
/locus_tag="Rv1211"
/product="Conserved protein"
/note="Rv1211, (MTCI364.23), len: 75 aa. Conserved
protein,similar to Q49958|U1756N Mycobacterium leprae (75
aa),FASTA scores: opt: 460, E(): 0, (90.7% identity in 75
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1211"
/db_xref="EnsemblGenomes-Tr:CCP43967"
/db_xref="GOA:O05312"
/db_xref="InterPro:IPR021465"
/db_xref="UniProtKB/TrEMBL:O05312"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43967.1"
/translation="MLGADQARAGGPARIWREHSMAAMKPRTGDGPLEATKEGRGIVM
RVPLEGGGRLVVELTPDEAAALGDELKGVTS"
gene complement(1354498..1355661)
/gene="glgA"
/locus_tag="Rv1212c"
CDS complement(1354498..1355661)
/codon_start=1
/transl_table=11
/gene="glgA"
/locus_tag="Rv1212c"
/product="Putative glycosyl transferase GlgA"
/note="Rv1212c, (MTCI364.24c), len: 387 aa. Putative
glgA,glycosyl transferase, highly similar to
AJ243803|SCO243803_2 Putative glycosyl transferase from
Streptomyces coelicolor (387 aa), FASTA scores: opt:
1344,E(): 0, (54.9% identity in 388 aa overlap). Also
similar to MJ1607 probable hexosyltransferase from
Methanococcus jannaschii (390 aa), FASTA scores: opt: 445,
E(): 7.8e-23,(27.9% identity in 401 aa overlap). The
region from aa 267-355 highly similar to Q49959 cosmid
B1756 from Mycobacterium leprae (91 aa), FASTA scores,
opt: 471, E(): 4.8e-25, (80.9% identity in 89 aa overlap).
Similar to Mycobacterium tuberculosis hypothetical
protein, Rv3032."
/db_xref="EnsemblGenomes-Gn:Rv1212c"
/db_xref="EnsemblGenomes-Tr:CCP43968"
/db_xref="GOA:P9WMZ1"
/db_xref="InterPro:IPR001296"
/db_xref="InterPro:IPR011875"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/Swiss-Prot:P9WMZ1"
/protein_id="CCP43968.1"
/translation="MRVAMLTREYPPEVYGGAGVHVTELVAYLRRLCAVDVHCMGAPR
PGAFAYRPDPRLGSANAALSTLSADLVMANAASAATVVHSHTWYTALAGHLAAILYDI
PHVLTAHSLEPLRPWKKEQLGGGYQVSTWVEQTAVLAANAVIAVSSAMRNDMLRVYPS
LDPNLVHVIRNGIDTETWYPAGPARTGSVLAELGVDPNRPMAVFVGRITRQKGVVHLV
TAAHRFRSDVQLVLCAGAADTPEVADEVRVAVAELARNRTGVFWIQDRLTIGQLREIL
SAATVFVCPSVYEPLGIVNLEAMACATAVVASDVGGIPEVVADGITGSLVHYDADDAT
GYQARLAEAVNALVADPATAERYGHAGRQRCIQEFSWAYIAEQTLDIYRKVCA"
gene 1355836..1357050
/gene="glgC"
/locus_tag="Rv1213"
CDS 1355836..1357050
/codon_start=1
/transl_table=11
/gene="glgC"
/locus_tag="Rv1213"
/product="Glucose-1-phosphate adenylyltransferase GlgC
(ADP-glucose synthase) (ADP-glucose pyrophosphorylase)"
/note="Rv1213, (MTCI364.25), len: 404 aa.
glgC,glucose-1-phosphate adenylyltransferase, similar to
many e.g. GLGC_ECOLI|P00584 Escherichia coli (430 aa),
FASTA scores: opt: 1075, E(): 0, (40.3% identity in 407 aa
overlap); highly similar to Q49961 GLGC from Mycobacterium
leprae (419 aa), FASTA scores: opt: 2532, E(): 0, (92.6%
identity in 404 aa overlap). Belongs to the bacterial and
plants glucose-1-phosphate adenylyltransferase family."
/db_xref="EnsemblGenomes-Gn:Rv1213"
/db_xref="EnsemblGenomes-Tr:CCP43969"
/db_xref="GOA:P9WN43"
/db_xref="InterPro:IPR005835"
/db_xref="InterPro:IPR005836"
/db_xref="InterPro:IPR011004"
/db_xref="InterPro:IPR011831"
/db_xref="InterPro:IPR023049"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WN43"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43969.1"
/translation="MREVPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFV
LSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGS
ADAIYQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIDSGAGATVAGIRVPRENA
TAFGCIDADDSGRIRSFVEKPLEPPGTPDDPDTTFVSMGNYIFTTKVLIDAIRADADD
DHSDHDMGGDIVPRLVADGMAAVYDFSDNEVPGATDRDRAYWRDVGTLDAFYDAHMDL
VSVHPVFNLYNKRWPIRGESENLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSN
VVVDDGAIVEGSVIMPGTRVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFAISA
GGVVAVGKGVWI"
gene complement(1357293..1357625)
/gene="PE14"
/locus_tag="Rv1214c"
CDS complement(1357293..1357625)
/codon_start=1
/transl_table=11
/gene="PE14"
/locus_tag="Rv1214c"
/product="PE family protein PE14"
/note="Rv1214c, (MTCI364.26c), len: 110 aa. PE14, Member
of Mycobacterium tuberculosis PE family (see citation
below),appears to be frameshifted but sequence appears to
be correct. The 5'-end is atypical as first 9 aa appear to
be missing."
/db_xref="EnsemblGenomes-Gn:Rv1214c"
/db_xref="EnsemblGenomes-Tr:CCP43970"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N6A7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43970.1"
/translation="MLASAATDLAGIGSALSAANAAAAAPTTAMLAACADEVSAVVAS
LFARHAQAYQALSLQATAFHQQFVQALTGAGGAYAAAEAVNAAVAQSVQQDVLNVINA
PTQALFDR"
gene complement(1357759..1359444)
/locus_tag="Rv1215c"
CDS complement(1357759..1359444)
/codon_start=1
/transl_table=11
/locus_tag="Rv1215c"
/product="Conserved protein"
/note="Rv1215c, (MTCI364.27c), len: 561 aa. Conserved
protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598
hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA
scores: opt: 257, E(): 1.3e-09, (34.1% identity in 185 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1215c"
/db_xref="EnsemblGenomes-Tr:CCP43971"
/db_xref="GOA:O05316"
/db_xref="InterPro:IPR000383"
/db_xref="InterPro:IPR005674"
/db_xref="InterPro:IPR008979"
/db_xref="InterPro:IPR013736"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O05316"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43971.1"
/translation="MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDPPADVV
IERDVEVPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRRRGNRWTFSPQYRM
LRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTGDLLSHQEAEDTYD
LVGWLADQAWSDGRVVMLGVSYLAISQYAVAALQPPALRAICPWEGFTDAYRDLAFPG
GIRESGFTRLWSRGVRRRTRQTYDMEQMQEAHPLRDDFWRSRVPDLSAIKVPMLVCGS
FSDNNLHSRGSIRAFTRSGCGHARLYTHRGGKWETFYSATALSEQLKFLRDALAGSSG
SRSVRLEVREDRDTITAVREETQWPLAGTRWRPMYLAGPGLLATEPPPTAGSIRFQTR
SRAAAFNWTIPEDIELTGPMAARLWVQLDGCDDANLFVGVEKWRDGQFVAFEGSYGWG
RDRVTTGWQRVSLRELDPELSQPWEPVPACARPRPVTAGEVVAVDVALGPSATLFRAG
EQLRLVVGGRWLSPRNPLTGQFPAAYPRPPRGRVTLHWGPRYDAHLLIPEVPG"
gene complement(1359472..1360146)
/locus_tag="Rv1216c"
CDS complement(1359472..1360146)
/codon_start=1
/transl_table=11
/locus_tag="Rv1216c"
/product="Probable conserved integral membrane protein"
/note="Rv1216c, (MTCI364.28c), len: 224 aa. Probable
conserved integral membrane protein, C-terminal region
similar to Q49963|U1756P from Mycobacterium leprae (134
aa), FASTA scores: opt: 311, E(): 3.3e-15, (52.2% identity
in 113 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1216c"
/db_xref="EnsemblGenomes-Tr:CCP43972"
/db_xref="InterPro:IPR007318"
/db_xref="UniProtKB/TrEMBL:O05317"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43972.1"
/translation="MHIGLKIFIWGVLGLVVFGALLFGPAGTFDYWQAWVFLAAFVST
TIGPTIYLARNDPAALQRRMRSGPLAEGRTIQKFIVIGAFLGFFAMMVLSACDHRYGW
SSVPAAVCVIGDVLVMTGLGIAMLVVIQNRYAASTVRVEAGQILASDGLYKIVRHPMY
AGNVVMMTGIPLALGSYWAMFILVPGTLVLVFRILDEEKLLTQELSGYREYRQLVRYR
LVPYVW"
gene complement(1360155..1361801)
/locus_tag="Rv1217c"
CDS complement(1360155..1361801)
/codon_start=1
/transl_table=11
/locus_tag="Rv1217c"
/product="Probable tetronasin-transport integral membrane
protein ABC transporter"
/note="Rv1217c, (MTCI364.29c), len: 548 aa. Probable
tetronasin-transport integral membrane ABC transporter
(see citation below), similar to many e.g.
AL049754|SCH10_12 probable ABC-type transport system
membrane-spanning protein from Streptomyces coelicolor
(539 aa), FASTA scores: opt: 1309, E(): 0, (40.9% identity
in 550 aa overlap); Q54407|X73633 TnrB3 protein from
Streptomyces longisporoflavus (337 aa), FASTA scores: opt:
692, E(): 0,(39.5% identity in 324 aa overlap); etc. Also
has regions similar to Mycobacterium leprae proteins
Q49964|U1756Q (109 aa), FASTA scores: opt: 431, E():
3.1e-20, (64.8% identity in 105 aa overlap) and
Q49965|U1756R (82 aa), FASTA scores: opt:154, E(): 0.0028,
(61.0% identity in 41 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1217c"
/db_xref="EnsemblGenomes-Tr:CCP43973"
/db_xref="GOA:O05318"
/db_xref="UniProtKB/Swiss-Prot:O05318"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43973.1"
/translation="MSSTVIDRARPAGHRAPHRGSGFTGTLGLLRLYLRRDRVSLPLW
VLLLSVPLATVYIASVETVYPDRSARAAAAAAIMASPAQRALYGPVYNDSLGAVGIWK
AGMFHTLIAVAVILTVIRHTRADEESGRAELIDSTVVGRYANLTGALLLSFGASIATG
AIGALGLLATDVAPAGSVAFGVALAASGMVFTAVAAVAAQLSPSARFTRAVAFAVLGT
AFALRAIGDAGSGTLSWCSPLGWSLQVRPYAGERWWVLLLSLATAAVLTVLAYRLRAG
RDVGAGLIAERPGAGTAGPMLSEPFGLAWRLNRGSLLLWTVGLCLYGLVMGSVVHGIG
DQLGDNTAVRDIVTRMGGTGALEQAFLALAFTMIGMVAAAFAVSLTLRLHQEETGLRA
ETLLAGAVSRTHWLASHLAMALAGSAVATLISGVAAGLAYGMTVGDVGGKLPTVVGTA
AVQLPAVWLLSAVTVGLFGLAPRFTPVAWGVLVGFIALYLLGSLAGFPQMLLNLEPFA
HIPRVGGGDFTAVPLLWLLAIDAALITLGAMAFRRRDVRC"
gene complement(1361798..1362733)
/locus_tag="Rv1218c"
CDS complement(1361798..1362733)
/codon_start=1
/transl_table=11
/locus_tag="Rv1218c"
/product="Probable tetronasin-transport ATP-binding
protein ABC transporter"
/note="Rv1218c, (MTCI61.01c), len: 311 aa. Probable
tetronasin-transport ATP-binding protein ABC transporter
(see citation below), similar to many e.g.
Q54406|X73633|TNRB2 TNRB2 protein from Streptomyces
longisporoflavus (300 aa), FASTA scores: opt: 1133, E():
0,(60.8% identity in 291 aa overlap); etc. Also similar to
others in Mycobacterium tuberculosis e.g. MTCY19H9.04
(30.0% identity in 297 aa overlap); etc. Contains PS00211
ABC transporters family signature and PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1218c"
/db_xref="EnsemblGenomes-Tr:CCP43974"
/db_xref="GOA:O86311"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR025302"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:O86311"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43974.1"
/translation="MSADNHQVPIEIRGLTKHFGSVRALDGLDLTVREGEVHGFLGPN
GAGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLWPSLTGGET
IDLLARMRGGIDNARRAELIERFGLDPTKKARTYSKGNRQKVSLISALSSHATLLLLD
EPSSGLDPLMENVFQQCIGEARQRGVTVLLSSHILAETEALCEKVTIIRAGKTVESGS
LDALRHLSRTSIKAEMIGDPGDLSQIKGVEDISIEGTTVRAQVDSESLRELIQVLGHA
GVRSLVSQPPTLEELFLRHYSLGPEVAAEQQVATP"
gene complement(1362723..1363361)
/locus_tag="Rv1219c"
CDS complement(1362723..1363361)
/codon_start=1
/transl_table=11
/locus_tag="Rv1219c"
/product="Probable transcriptional regulatory protein"
/note="Rv1219c, (MTCI61.02c), len: 212 aa. Probable
transcriptional regulatory protein, some similarity in
N-terminus to YBIH_ECOLI|P41037 hypothetical
transcriptional regulator from Escherichia coli (103
aa),FASTA scores: opt: 143, E(): 8.9e-06, (39.7% identity
in 63 aa overlap); Helix turn helix motif from aa 28-49."
/db_xref="EnsemblGenomes-Gn:Rv1219c"
/db_xref="EnsemblGenomes-Tr:CCP43975"
/db_xref="GOA:O86312"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041484"
/db_xref="PDB:4NN1"
/db_xref="UniProtKB/Swiss-Prot:O86312"
/protein_id="CCP43975.1"
/translation="MRSADLTAHARIREAAIEQFGRHGFGVGLRAIAEAAGVSAALVI
HHFGSKEGLRKACDDFVAEEIRSSKAAALKSNDPTTWLAQMAEIESYAPLMAYLVRSM
QSGGELAKMLWQKMIDNAEEYLDEGVRAGTVKPSRDPRARARFLAITGGGGFLLYLQM
HENPTDLRAALRDYAHDMVLPSLEVYTEGLLADRAMYEAFLAEAQQGEAHVG"
gene complement(1363503..1364150)
/locus_tag="Rv1220c"
CDS complement(1363503..1364150)
/codon_start=1
/transl_table=11
/locus_tag="Rv1220c"
/product="Probable methyltransferase"
/note="Rv1220c, (MTCI61.03c), len: 215 aa. Possible
methyltransferase, some similarity to MDMC_STRMY|Q00719
o-methyltransferase from Streptomyces mycarofaciens (221
aa), FASTA scores; opt: 289, E(): 1.3e-07, (30.0% identity
in 203 aa overlap). Also similar to Mycobacterium
tuberculosis methyltransferases Rv0187|MTCI28.26 (32.9%
identity in 222 aa overlap) and Rv1703c. Start site chosen
by homology; other possible start sites exist upstream."
/db_xref="EnsemblGenomes-Gn:Rv1220c"
/db_xref="EnsemblGenomes-Tr:CCP43976"
/db_xref="GOA:P9WJZ7"
/db_xref="InterPro:IPR002935"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:5X7F"
/db_xref="UniProtKB/Swiss-Prot:P9WJZ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43976.1"
/translation="MPGQPAPSRGESLWAHAEGSISEDVILAGARERATDIGAGAVTP
AVGALLCLLAKLSGGKAVAEVGTGAGVSGLWLLSGMRDDGVLTTIDIEPEHLRLARQA
FAEAGIGPSRTRLISGRAQEVLTRLADASYDLVFIDADPIDQPDYVAEGVRLLRSGGV
IVVHRAALGGRAGDPGARDAEVIAVREAARLIAEDERLTPALVPLGDGVLAAVRD"
gene 1364413..1365186
/gene="sigE"
/locus_tag="Rv1221"
CDS 1364413..1365186
/codon_start=1
/transl_table=11
/gene="sigE"
/locus_tag="Rv1221"
/product="Alternative RNA polymerase sigma factor SigE"
/note="Rv1221, (MTCI61.04), len: 257 aa. SigE, alternative
sigma factor of extracytoplasmic function (ECF) family
(see citations below). Similar to many e.g.
RPOE_HAEIN|P44790 RNA polymerase sigma-e factor from
Haemophilus influenzae (189 aa), FASTA scores: opt: 247,
E(): 3.4e-06, (28.5% identity in 186 aa overlap); etc.
Also similar to MTCY07D11.03 rpoE from Mycobacterium
tuberculosis (35.2% identity in 159 aa overlap). Belongs
to the sigma-70 factor family, ECF subfamily. Three
promoters and three translational start codons have been
detected (See Dona et al., 2008). Fourth transcriptional
start point has been identified (See Pang et al., 2007).
Note that in Mycobacterium bovis BCG, the sigE gene is
transcribed from two promoters, P1 and P2, and that these
promoters were expressed at temperatures from 30-50
degrees Celsius."
/db_xref="EnsemblGenomes-Gn:Rv1221"
/db_xref="EnsemblGenomes-Tr:CCP43977"
/db_xref="GOA:P9WGG7"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039425"
/db_xref="PDB:6JCY"
/db_xref="UniProtKB/Swiss-Prot:P9WGG7"
/protein_id="CCP43977.1"
/translation="MELLGGPRVGNTESQLCVADGDDLPTYCSANSEDLNITTITTLS
PTSMSHPQQVRDDQWVEPSDQLQGTAVFDATGDKATMPSWDELVRQHADRVYRLAYRL
SGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALP
EDYDRVPADEPNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATL
GVKLGTVRSRIHRGRQALRDYLAAHPEHGECAVHVNPVR"
gene 1365274..1365365
/gene="mpr6"
ncRNA 1365274..1365365
/gene="mpr6"
/product="Fragment of putative small regulatory RNA"
/note="mpr6, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), ends not mapped, ~118 nt band
detected by Northern blot in M. bovis BCG Pasteur."
/ncRNA_class="other"
gene 1365344..1365808
/gene="rseA"
/locus_tag="Rv1222"
CDS 1365344..1365808
/codon_start=1
/transl_table=11
/gene="rseA"
/locus_tag="Rv1222"
/product="Anti-sigma factor RseA"
/note="Rv1222, (MTCI61.05), len: 154 aa. RseA, anti-sigma
factor (See Dona et al., 2008). Identical to
O06290|MTU87242 (but shorter due to different start site
chosen by proximity of RBS). Equivalent to
O05736|U87308|MAU87308_2 hypothetical protein from
Mycobacterium avium (133 aa), FASTA scores: opt: 644, E():
7e-32, (86.2% identity in 109 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1222"
/db_xref="EnsemblGenomes-Tr:CCP43978"
/db_xref="GOA:L0T905"
/db_xref="UniProtKB/Swiss-Prot:L0T905"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43978.1"
/translation="MADPGSVGHVFRRAFSWLPAQFASQSDAPVGAPRQFRSTEHLSI
EAIAAFVDGELRMNAHLRAAHHLSLCAQCAAEVDDQSRARAALRDSHPIRIPSTLLGL
LSEIPRCPPEGPSKGSSGGSSQGPPDGAAAGFGDRFADGDGGNRGRQSRVRR"
gene 1365875..1367461
/gene="htrA"
/gene_synonym="degP"
/locus_tag="Rv1223"
CDS 1365875..1367461
/codon_start=1
/transl_table=11
/gene="htrA"
/gene_synonym="degP"
/locus_tag="Rv1223"
/product="Probable serine protease HtrA (DEGP protein)"
/note="Rv1223, (MTCI61.06), len: 528 aa. Probable htrA
(alternate gene name: degP), serine protease precursor
(see citations below), equivalent to
U15180|MLU15180_31|Q49972|ML1078|HTRA possible serine
protease from Mycobacterium leprae (533 aa), FASTA scores:
opt: 2777, E(): 4.1e-141, (81.6% identity in 533 aa
overlap). Also similar to many others e.g.
HTRA_ECOLI|P09376 protease do precursor from Escherichia
coli (474 aa), FASTA scores: opt: 581, E(): 9.1e-27,
(36.3% identity in 278 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Start changed since
first submission (-21 aa). Conserved in M. tuberculosis,
M. leprae, M. bovis and M. avium paratuberculosis;
predicted to be essential for in vivo survival and
pathogenicity (See Ribeiro-Guimaraes and Pessolani,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv1223"
/db_xref="EnsemblGenomes-Tr:CCP43979"
/db_xref="GOA:O06291"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR001940"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR036034"
/db_xref="PDB:5ZVJ"
/db_xref="PDB:6IEO"
/db_xref="UniProtKB/TrEMBL:O06291"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43979.1"
/translation="MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPR
PVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGR
PFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALA
GSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLST
TGNAQEPAGRFTKVAAAVADSVVTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAA
NNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDE
VLAVGAPLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLI
DMDAQVIGINTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGISTRSVS
NAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRAVADSDEFVVAVRQLAIGQDAPI
EVVREGRHVTLTVKPDPDST"
gene 1367463..1367858
/gene="tatB"
/locus_tag="Rv1224"
CDS 1367463..1367858
/codon_start=1
/transl_table=11
/gene="tatB"
/locus_tag="Rv1224"
/product="Probable protein TatB"
/note="Rv1224, (MTCI61.07), len: 131 aa. Probable
tatB,component of twin-arginine translocation protein
export system (see citation below). Possible exported
protein with hydrophobic stretch at N-terminus. Highly
similar to Q49973|U15180 hypothetical protein U1756Y from
Mycobacterium leprae (120 aa), FASTA scores: opt: 601,
E(): 0, (73.3% identity in 131 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1224"
/db_xref="EnsemblGenomes-Tr:CCP43980"
/db_xref="GOA:P9WG99"
/db_xref="InterPro:IPR003369"
/db_xref="InterPro:IPR018448"
/db_xref="UniProtKB/Swiss-Prot:P9WG99"
/protein_id="CCP43980.1"
/translation="MFANIGWWEMLVLVMVGLVVLGPERLPGAIRWAASALRQARDYL
SGVTSQLREDIGPEFDDLRGHLGELQKLRGMTPRAALTKHLLDGDDSLFTGDFDRPTP
KKPDAAGSAGPDATEQIGAGPIPFDSDAT"
gene complement(1367891..1368721)
/locus_tag="Rv1225c"
CDS complement(1367891..1368721)
/codon_start=1
/transl_table=11
/locus_tag="Rv1225c"
/product="Conserved hypothetical protein"
/note="Rv1225c, (MTCI61.08c), len: 276 aa. Conserved
hypothetical protein, some similarity to other
hypothetical proteins e.g. AE001078|AE001078_2
Archaeoglobus fulgidus (265 aa), FASTA scores: opt: 339,
E(): 5.1e-15, (27.1% identity in 262 aa overlap), and to
NAGD_ECOLI|P15302 nagd protein from Escherichia coli (250
aa), FASTA scores: opt: 167, E(): 6.4e-12, (24.8% identity
in 258 aa overlap). Also weakly similar to Mycobacterium
tuberculosis hypothetical protein Rv3400|MTCY78.28c (29.1%
identity in 251 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1225c"
/db_xref="EnsemblGenomes-Tr:CCP43981"
/db_xref="GOA:O33221"
/db_xref="InterPro:IPR006355"
/db_xref="InterPro:IPR006357"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/TrEMBL:O33221"
/protein_id="CCP43981.1"
/translation="MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACA
YLTNTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYPGARCFLVNNGDIT
EDLPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVYGWMLDGVPVVAMHR
NMTWNTTDGLRIDTGMYLTGMEQACGKTATAIGKPAAEGFLAAADRVGVDPQQMVMIG
DDLHNDVLAAQAVGMTGVLVRTGKFRQQTLDRWLAGASATRPHHVIDSVAGLPPLLGC
"
gene complement(1368832..1370295)
/locus_tag="Rv1226c"
CDS complement(1368832..1370295)
/codon_start=1
/transl_table=11
/locus_tag="Rv1226c"
/product="Probable transmembrane protein"
/note="Rv1226c, (MTCI61.09c), len: 487 aa. Probable
transmembrane protein. Some similarity to AL049841|SCE9.01
Streptomyces coelicolor (436 aa), FASTA scores: opt:
203,E(): 1.2e-05, (29.8% identity in 346 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1226c"
/db_xref="EnsemblGenomes-Tr:CCP43982"
/db_xref="GOA:O33222"
/db_xref="InterPro:IPR005182"
/db_xref="InterPro:IPR014529"
/db_xref="UniProtKB/TrEMBL:O33222"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43982.1"
/translation="MTDRPHDWHRLSPRMLLVHPVHEMLRQLPVLIGSVVLGSATGNP
VWPLAALGVTVVFGVLRWFFTTYRIDDENVSLRTGILSRRAVSVPRNRIRSVQTEARL
LHRLLGLTVLRVGTGQEARGEAAFELDAVDSARVPRLRALLLAESLAPVEPTGRVLAR
WQSSWLRYAPLSFSGLVMIGAVIGLGYQTGLAVRLPESGFARSAVDAAQRAGVVLVVA
VTVLLVVGVSALLAVLFSWLTYGNLLLRRGGSGQEGVLHLRHGLLRVREHTYDMRRLR
GATLREPLLVRLLRGARLDAVMTGVHGEGQSSMLLPPCPFETATAVLTDLIDNTDAAA
GPLRRHGPAAARRRWTRALLVPTLAGVALIAAAPILGVPGWAWTLWAVLTAGCAGLAV
DRVRSLGHRVADGWLVARAGSLQRRRDCIACTGIIGWTVRQTLFQRRAGVATLVAATV
AGRKGYQVLDVPAELAWSVAGAASPWVADSVWLRHGS"
gene complement(1370292..1370825)
/locus_tag="Rv1227c"
CDS complement(1370292..1370825)
/codon_start=1
/transl_table=11
/locus_tag="Rv1227c"
/product="Probable transmembrane protein"
/note="Rv1227c, (MTCI61.10c), len: 177 aa. Possible
transmembrane protein, similar to P96615 hypothetical
protein ydbS from Bacillus subtilis (159 aa), fasta
scores: E(): 3.6e-07, (30.1% identity in 163 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1227c"
/db_xref="EnsemblGenomes-Tr:CCP43983"
/db_xref="GOA:O33223"
/db_xref="InterPro:IPR005182"
/db_xref="UniProtKB/TrEMBL:O33223"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43983.1"
/translation="MDHARNVPSATGPQRNHLALAEPAHRPSSQAPVMWALSASLGWI
LPVIAQLVWWAVHPQPPWPHLAAAALTAVAMVVHIGVVPLWRYRVHRWEISPQAVFTR
TGWLVQERRITPISRVQTVDTYRGPMDRLFGLANVTVTTASSAGAVHIEALDTDVADR
VVAQLTDIAALRGEDAT"
gene 1370920..1371477
/gene="lpqX"
/locus_tag="Rv1228"
CDS 1370920..1371477
/codon_start=1
/transl_table=11
/gene="lpqX"
/locus_tag="Rv1228"
/product="Probable lipoprotein LpqX"
/note="Rv1228, (MTCI61.11), len: 185 aa. Probable
lipoprotein LpqX. Contains possible signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1228"
/db_xref="EnsemblGenomes-Tr:CCP43984"
/db_xref="UniProtKB/TrEMBL:O33224"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43984.1"
/translation="MSRQWHWLAATLLLITTAACSRPGTEEPDCPTKITLPPGATPTT
TLDPRCIVRATTTGTADGDAASRWTGTVRIAGFYASICNAVWDGNVSLAGKDELTGKA
TLILVETSCPGKVVAGELVLKGNVGSDSLAITWAHPELPQRAFDLGAGQGTIRRSGDR
AEGTFNSDMGGGTEFFLTWSLTMRN"
gene complement(1371777..1372949)
/gene="mrp"
/locus_tag="Rv1229c"
CDS complement(1371777..1372949)
/codon_start=1
/transl_table=11
/gene="mrp"
/locus_tag="Rv1229c"
/product="Probable Mrp-related protein Mrp"
/note="Rv1229c, (MT1267, MTCI61.12c, MTV006.01c), len: 390
aa. Probable Mrp protein, similar to others e.g.
MRP_ECOLI|P21590 mrp protein from Escherichia coli (379
aa), FASTA scores: E(): 0, (34.1% identity in 355 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop); and PS01215 MRP Prosite domain. Belongs to the
MRP/NBP35 family of ATP-binding proteins."
/db_xref="EnsemblGenomes-Gn:Rv1229c"
/db_xref="EnsemblGenomes-Tr:CCP43985"
/db_xref="GOA:P9WJN7"
/db_xref="InterPro:IPR000808"
/db_xref="InterPro:IPR002744"
/db_xref="InterPro:IPR019591"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR033756"
/db_xref="InterPro:IPR034904"
/db_xref="UniProtKB/Swiss-Prot:P9WJN7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43985.1"
/translation="MPSRLHSAVMSGTRDGDLNAAIRTALGKVIDPELRRPITELGMV
KSIDTGPDGSVHVEIYLTIAGCPKKSEITERVTRAVADVPGTSAVRVSLDVMSDEQRT
ELRKQLRGDTREPVIPFAQPDSLTRVYAVASGKGGVGKSTVTVNLAAAMAVRGLSIGV
LDADIHGHSIPRMMGTTDRPTQVESMILPPIAHQVKVISIAQFTQGNTPVVWRGPMLH
RALQQFLADVYWGDLDVLLLDLPPGTGDVAISVAQLIPNAELLVVTTPQLAAAEVAER
AGSIALQTRQRIVGVVENMSGLTLPDGTTMQVFGEGGGRLVAERLSRAVGADVPLLGQ
IPLDPALVAAGDSGVPLVLSSPDSAIGKELHSIADGLSTRRRGLAGMSLGLDPTRR"
gene complement(1372962..1374197)
/locus_tag="Rv1230c"
CDS complement(1372962..1374197)
/codon_start=1
/transl_table=11
/locus_tag="Rv1230c"
/product="Possible membrane protein"
/note="Rv1230c, (MTV006.02c), len: 411 aa. Possible
membrane protein with two hydrophobic stretches near
N-terminus. Some similarity to Rv1022|MTCY10G2.27c|Z92539
probable lpqU protein Mycobacterium tuberculosis (243
aa),FASTA score: opt: 408, E(): 1e-11, (43.6% identity in
172 aa overlap). Similar to AL133423|SC4A7.37 hypothetical
protein from Streptomyces coelicolor (421 aa), FASTA
score: opt: 679, E(): 5.1e-23, (36.4% identity in 398 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1230c"
/db_xref="EnsemblGenomes-Tr:CCP43986"
/db_xref="GOA:O86313"
/db_xref="InterPro:IPR001827"
/db_xref="InterPro:IPR023346"
/db_xref="InterPro:IPR031304"
/db_xref="UniProtKB/TrEMBL:O86313"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43986.1"
/translation="MHIGGRWGARPAVAAVRRGACRLTRAPAFGVAAIAPLVFASAVG
SAAPVFPGRTAPVHAVITPVAAVAASGIDLSGPVVIAMKRPPTSFRVAVATISAPPPP
MIVNSPGALGIPAMALSAYRNAELKMAAAAPGCGVSWNLLAGIGRIESMHANGGATDA
RGTAIQPIYGPTLDGTLPGNEIIIQSSVGNRVTYARAMGPMQFLPGTWARYATDGDDD
GVADPQNLFDSTLAAARYLCSGGLNLRDPAQVMAALLRYNNSMPYAQNVLGWAAGYAT
GVFPVDLPPITGPPPPLGDAHLENPEGLGPGLPINVNGLTADGPMAHLPLIDLTPRQA
ALNPPPMFPWMAPDPSAPMPGCTLICIGSHGPPVGAPPFPPTAPPPPFLPAAPPPPDP
LAGPPGDAGLAPPAPAPAG"
gene complement(1374322..1374864)
/locus_tag="Rv1231c"
CDS complement(1374322..1374864)
/codon_start=1
/transl_table=11
/locus_tag="Rv1231c"
/product="Probable membrane protein"
/note="Rv1231c, (MTV006.03c), len: 180 aa. Probable
membrane protein, similar to others e.g. AL390975
Streptomyces coelicolor (198 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1231c"
/db_xref="EnsemblGenomes-Tr:CCP43987"
/db_xref="GOA:O86314"
/db_xref="InterPro:IPR010406"
/db_xref="UniProtKB/TrEMBL:O86314"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43987.1"
/translation="MSKPFAPRRLYTPRTSRTLAPRLDPEAVGRTTESIARFFGTGRY
LLVQTLLVLTWIVLNLFAVGLRWDPYPFILLNLAFSTQASYAAPLILLAQNRQEKRDR
AVFEEDRRRAAQTKADTEYNARELAALRLAIGEVPTRDYLRHELDSLRALLAELQPTD
PDVAQPRVADEAEQHAKKSG"
gene complement(1374861..1376168)
/locus_tag="Rv1232c"
CDS complement(1374861..1376168)
/codon_start=1
/transl_table=11
/locus_tag="Rv1232c"
/product="Conserved protein"
/note="Rv1232c, (MTV006.04c), len: 435 aa. Conserved
protein, similar to other hypothetical proteins e.g.
AB013374|AB013374_2 Bacillus halodurans C-125 mamX (449
aa), FASTA scores: opt: 381, E(): 1e-16, (29.9% identity
in 251 aa overlap). Some similarity in N-terminus to
U15180|MLU1518033 hypothetical Mycobacterium leprae
protein u1756u (329 aa), FASTA scores: opt: 300, E():
4.1e-12,(69.3% identity in 75 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1232c"
/db_xref="EnsemblGenomes-Tr:CCP43988"
/db_xref="GOA:O86315"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR006668"
/db_xref="InterPro:IPR006669"
/db_xref="InterPro:IPR011033"
/db_xref="InterPro:IPR038076"
/db_xref="UniProtKB/TrEMBL:O86315"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43988.1"
/translation="MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRV
LGLVVDLATRRKIFIPILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLV
KVNDPALPELAGVDVVVTDLGVEQTRSRDWMVTRVAVRTQRRLRRRCPVHVVDWHNVA
GLTPSALAMPGQDVAQLLDQFEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQ
ELPELDQAEVLSQLGTERAADVLEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQV
RRLLTHSPDTAGGLMTSDPVVLTPDTSIAEALARVRDPDLTPALASMVFVARPPTATP
TGHYLGCVHLQRLLRDPPAELVGGVVDTDLLTLTPETPLAAVTRYFAAYNLVCGPVVD
DENHLLGAVTVDDLLDHLLPHDWRVDMPELDPSGAPDRPGGPR"
gene complement(1376230..1376826)
/locus_tag="Rv1233c"
CDS complement(1376230..1376826)
/codon_start=1
/transl_table=11
/locus_tag="Rv1233c"
/product="Conserved hypothetical membrane protein"
/note="Rv1233c, (MTV006.05c), len: 198 aa. Conserved
hypothetical membrane protein, N-terminus is highly
proline rich, C-terminus has two hydrophobic stretches.
Proline-rich N-terminus has some similarity to CBPA_DICDI
calcium binding protein from Dictyostelium discoideum (467
aa), FASTA scores: E(): 4.8e-06, (35.5% identity in 183 aa
overlap). Both sequences share multiple copies of a
Tyr-Pro-Pro motif."
/db_xref="EnsemblGenomes-Gn:Rv1233c"
/db_xref="EnsemblGenomes-Tr:CCP43989"
/db_xref="GOA:O86316"
/db_xref="InterPro:IPR025241"
/db_xref="UniProtKB/TrEMBL:O86316"
/protein_id="CCP43989.1"
/translation="MTAPSGSSGESAHDAAGGPPPVGERPPEQPIADAPWAPPASSPM
ANHPPPAYPPSGYPPAYQPGYPTGYPPPMPPGGYAPPGYPPPGTSSAGYGDIPYPPMP
PPYGGSPGGYYPEPGYLDGYGPSQPGMNTMALVSLISALVGVLCCIGSIVGIVFGAIA
INQIKQTREEGYGLAVAGIVIGIATLLVYMIAGIFAIP"
gene 1376976..1377503
/locus_tag="Rv1234"
CDS 1376976..1377503
/codon_start=1
/transl_table=11
/locus_tag="Rv1234"
/product="Probable transmembrane protein"
/note="Rv1234, (MTV006.06), len: 175 aa. Possible
transmembrane protein with two TM helices."
/db_xref="EnsemblGenomes-Gn:Rv1234"
/db_xref="EnsemblGenomes-Tr:CCP43990"
/db_xref="GOA:O50451"
/db_xref="UniProtKB/TrEMBL:O50451"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43990.1"
/translation="MTSPFQPRQVPGSTPAAAGAGRRGVPALPTPPKGWPVGSYPTYA
EAQRAVDYLSEQQFPVQQVTIVGVDLMQVERVTGRLTWPKVLGGGVLSGAWLGLFIGL
VLGFFSPNPWSALVTGLVAGVFFGLITSAVPYAMARGTRDFSSTMQLVAGRYDVLCDP
QNAEKARDLLARLAI"
gene 1377524..1378930
/gene="lpqY"
/locus_tag="Rv1235"
CDS 1377524..1378930
/codon_start=1
/transl_table=11
/gene="lpqY"
/locus_tag="Rv1235"
/product="Probable sugar-binding lipoprotein LpqY"
/note="Rv1235, (MTV006.07), len: 468 aa. Probable
lpqY,sugar-binding lipoprotein component of sugar
transport system (see citation below), equivalent to
MLU1518034 protein u1756v from Mycobacterium leprae (469
aa), FASTA scores: opt: 2442, E(): 0, (77.4% identity in
470 aa overlap). Also similar to P18815|MALE_ENTAE
maltose-binding periplasmic protein from Enterobacter
aerogenes (396 aa),FASTA scores: opt: 193, E(): 2.3e-05,
(24.2% identity in 297 aa overlap). Contains PS00013
Prokaryotic membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1235"
/db_xref="EnsemblGenomes-Tr:CCP43991"
/db_xref="GOA:P9WGU9"
/db_xref="InterPro:IPR006059"
/db_xref="UniProtKB/Swiss-Prot:P9WGU9"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43991.1"
/translation="MVMSRGRIPRLGAAVLVALTTAAAACGADSQGLVVSFYTPATDG
ATFTAIAQRCNQQFGGRFTIAQVSLPRSPNEQRLQLARRLTGNDRTLDVMALDVVWTA
EFAEAGWALPLSDDPAGLAENDAVADTLPGPLATAGWNHKLYAAPVTTNTQLLWYRPD
LVNSPPTDWNAMIAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLVSAGGSVLSEDG
RHVTLTDTPAHRAATVSALQILKSVATTPGADPSITRTEEGSARLAFEQGKAALEVNW
PFVFASMLENAVKGGVPFLPLNRIPQLAGSINDIGTFTPSDEQFRIAYDASQQVFGFA
PYPAVAPGQPAKVTIGGLNLAVAKTTRHRAEAFEAVRCLRDQHNQRYVSLEGGLPAVR
ASLYSDPQFQAKYPMHAIIRQQLTDAAVRPATPVYQALSIRLAAVLSPITEIDPESTA
DELAAQAQKAIDGMGLLP"
gene 1378927..1379850
/gene="sugA"
/locus_tag="Rv1236"
CDS 1378927..1379850
/codon_start=1
/transl_table=11
/gene="sugA"
/locus_tag="Rv1236"
/product="Probable sugar-transport integral membrane
protein ABC transporter SugA"
/note="Rv1236, (MTV006.08), len: 307 aa. Probable
sugA,sugar-transport integral membrane protein ABC
transporter (see citation below), equivalent to
U15180|MLU1518035 protein malFM from Mycobacterium leprae
(310 aa), FASTA scores: opt: 1566, E(): 0, (81.8% identity
in 292 aa overlap). Also similar to numerous bacterial
sugar transport system components. Also similar to
Rv2316|MTCY3G12.18c from Mycobacterium tuberculosis (290
aa), FASTA scores: opt: 514, E(): 7.3e-27, (33.2% identity
in 283 aa overlap). Contains PS00402
Binding-protein-dependent transport systems inner membrane
comp signature."
/db_xref="EnsemblGenomes-Gn:Rv1236"
/db_xref="EnsemblGenomes-Tr:CCP43992"
/db_xref="GOA:P9WG03"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WG03"
/inference="protein motif:PROSITE:PS00402"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43992.1"
/translation="MTSVEQRTATAVFSRTGSRMAERRLAFMLVAPAAMLMVAVTAYP
IGYALWLSLQRNNLATPNDTAFIGLGNYHTILIDRYWWTALAVTLAITAVSVTIEFVL
GLALALVMHRTLIGKGLVRTAVLIPYGIVTVVASYSWYYAWTPGTGYLANLLPYDSAP
LTQQIPSLGIVVIAEVWKTTPFMSLLLLAGLALVPEDLLRAAQVDGASAWRRLTKVIL
PMIKPAIVVALLFRTLDAFRIFDNIYVLTGGSNNTGSVSILGYDNLFKGFNVGLGSAI
SVLIFGCVAVIAFIFIKLFGAAAPGGEPSGR"
gene 1379855..1380679
/gene="sugB"
/locus_tag="Rv1237"
CDS 1379855..1380679
/codon_start=1
/transl_table=11
/gene="sugB"
/locus_tag="Rv1237"
/product="Probable sugar-transport integral membrane
protein ABC transporter SugB"
/note="Rv1237, (MTV006.09), len: 274 aa. Probable
sugB,sugar-transport integral membrane protein ABC
transporter (see citation below), equivalent to
U15180|MLU1518036 protein MalGM from Mycobacterium leprae
(296 aa), FASTA scores: opt: 1571, E(): 0, (89.8% identity
in 274 aa overlap). Also similar to numerous bacterial
sugar transport protein. Related to Rv2834c|MTCY16B7.08
from Mycobacterium tuberculosis (275 aa), FASTA scores:
opt: 370, E(): 2.4e-17, (26.8% identity in 269 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1237"
/db_xref="EnsemblGenomes-Tr:CCP43993"
/db_xref="GOA:P9WG01"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WG01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43993.1"
/translation="MGARRATYWAVLDTLVVGYALLPVLWIFSLSLKPTSTVKDGKLI
PSTVTFDNYRGIFRGDLFSSALINSIGIGLITTVIAVVLGAMAAYAVARLEFPGKRLL
IGAALLITMFPSISLVTPLFNIERAIGLFDTWPGLILPYITFALPLAIYTLSAFFREI
PWDLEKAAKMDGATPGQAFRKVIVPLAAPGLVTAAILVFIFAWNDLLLALSLTATKAA
ITAPVAIANFTGSSQFEEPTGSIAAGAIVITIPIIVFVLIFQRRIVAGLTSGAVKG"
gene 1380684..1381865
/gene="sugC"
/locus_tag="Rv1238"
CDS 1380684..1381865
/codon_start=1
/transl_table=11
/gene="sugC"
/locus_tag="Rv1238"
/product="Probable sugar-transport ATP-binding protein ABC
transporter SugC"
/note="Rv1238, (MTV006.10), len: 393 aa. Probable
sugC,sugar-transport ATP-binding protein ABC transporter
(see citation below). Highly similar to U15180 protein
ugpC from Mycobacterium leprae (392 aa), FASTA score: opt:
2007, E(): 0, (79.9% identity in 389 aa overlap). Contains
PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211
ABC transporters family signature. Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1238"
/db_xref="EnsemblGenomes-Tr:CCP43994"
/db_xref="GOA:P9WQI3"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR008995"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR040582"
/db_xref="UniProtKB/Swiss-Prot:P9WQI3"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43994.1"
/translation="MAEIVLDHVNKSYPDGHTAVRDLNLTIADGEFLILVGPSGCGKT
TTLNMIAGLEDISSGELRIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLT
LAKMRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQRVAMGRAIVRHPKAFLMDE
PLSNLDAKLRVQMRGEIAQLQRRLGTTTVYVTHDQTEAMTLGDRVVVMYGGIAQQIGT
PEELYERPANLFVAGFIGSPAMNFFPARLTAIGLTLPFGEVTLAPEVQGVIAAHPKPE
NVIVGVRPEHIQDAALIDAYQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQL
DELAEVEGESALHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTIPHR
A"
gene complement(1381942..1383042)
/gene="corA"
/locus_tag="Rv1239c"
CDS complement(1381942..1383042)
/codon_start=1
/transl_table=11
/gene="corA"
/locus_tag="Rv1239c"
/product="Possible magnesium and cobalt transport
transmembrane protein CorA"
/note="Rv1239c, (MTV006.11c), len: 366 aa. Possible
corA,magnesium and cobalt transport transmembrane
protein,highly similar to U15180 corA protein from
Mycobacterium leprae (373 aa), FASTA scores: opt: 1985,
E(): 0, (79.1% identity in 369 aa overlap). Also similar
to various CorA proteins of Gram negative bacteria e.g.
P27841|CORA_ECOLI|B3816|Z5333|ECS4746 Magnesium and cobalt
transport protein from Escherichia coli strains K12 and
O157:H7 (316 aa), FASTA scores: opt: 236, E():
8e-08,(24.5% identity in 306 aa overlap); etc. Seems to
belong to the MIT family."
/db_xref="EnsemblGenomes-Gn:Rv1239c"
/db_xref="EnsemblGenomes-Tr:CCP43995"
/db_xref="GOA:O50455"
/db_xref="InterPro:IPR002523"
/db_xref="InterPro:IPR004488"
/db_xref="UniProtKB/TrEMBL:O50455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43995.1"
/translation="MFPGFDALPEVLRPVARPQPPNAHPVAQPPAQALVDCGVYVCGQ
RLPGKYTYAAALREVREIELTGQEAFVWIGLHEPDENQMQDVADVFGLHPLAVEDAVH
AHQRPKLERYDETLFLVLKTVNYVPHESVVLAREIVKTGEIMIFVGKDFVVTVRHGEH
GGLSEVRKRMDADPEHLRLGPYAVMHAIADYVVDHYLEVTNLMETDIDSIEEVAFAPG
RKLDIEPIYLLKREVVELRRCVNPLSTAFQRMQTESKDLISKEVRRYLRDVADHQTEA
ADQIASYDDMLNSLVQAALARVGMQQNMDMRKISAWAGIIAVPTMIAGIYGMNFHFMP
ELDSRWGYPTVIGGMVLICLFLYHVFRNRNWL"
gene 1383213..1384202
/gene="mdh"
/locus_tag="Rv1240"
CDS 1383213..1384202
/codon_start=1
/transl_table=11
/gene="mdh"
/locus_tag="Rv1240"
/product="Probable malate dehydrogenase Mdh"
/note="Rv1240, (MTV006.12), len: 329 aa. Probable
mdh,Malate dehydrogenase. Most similar to P50917|MDH_MYCLE
malate dehydrogenase from Mycobacterium leprae (329
aa),FASTA scores: opt: 1887, E(): 0, (89.1% identity in
329 aa overlap). Contains PS00068 Malate dehydrogenase
active site signature. Belongs to the LDH family. MDH
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1240"
/db_xref="EnsemblGenomes-Tr:CCP43996"
/db_xref="GOA:P9WK13"
/db_xref="InterPro:IPR001236"
/db_xref="InterPro:IPR001252"
/db_xref="InterPro:IPR001557"
/db_xref="InterPro:IPR010945"
/db_xref="InterPro:IPR015955"
/db_xref="InterPro:IPR022383"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:4TVO"
/db_xref="PDB:5KVV"
/db_xref="UniProtKB/Swiss-Prot:P9WK13"
/inference="protein motif:PROSITE:PS00068"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43996.1"
/translation="MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEI
EPALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDL
LEANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLD
HNRAISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIED
EFIPTVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGV
PEGLISSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELGLI"
gene 1384278..1384538
/gene="vapB33"
/locus_tag="Rv1241"
CDS 1384278..1384538
/codon_start=1
/transl_table=11
/gene="vapB33"
/locus_tag="Rv1241"
/product="Possible antitoxin VapB33"
/note="Rv1241, (MTV006.13), len: 86 aa. Possible
vapB33,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1242,see Arcus et al. 2005. Member of family of 16
hypothetical Mycobacterium tuberculosis proteins
including: Rv2871|Q10799|YS71_MYCTU hypothetical 13.2 kDa
protein CY2 (124 aa), FASTA scores: opt: 172, E():
9.5e-06, (37.2% identity in 86 aa overlap); Rv2132,
Rv3321c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1241"
/db_xref="EnsemblGenomes-Tr:CCP43997"
/db_xref="GOA:O50456"
/db_xref="UniProtKB/Swiss-Prot:O50456"
/protein_id="CCP43997.1"
/translation="MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKR
QEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLDATRRAR"
gene 1384535..1384966
/gene="vapC33"
/locus_tag="Rv1242"
CDS 1384535..1384966
/codon_start=1
/transl_table=11
/gene="vapC33"
/locus_tag="Rv1242"
/product="Possible toxin VapC33. Contains PIN domain."
/note="Rv1242, (MTV006.14), len: 143 aa. Possible
vapC33,toxin, part of toxin-antitoxin (TA) operon with
Rv1241,contains PIN domain, see Arcus et al. 2005. Member
of family of 14 hypothetical Mycobacterium tuberculosis
proteins including: Rv2872|Q10800|YS72_MYCTU (147
aa),FASTA scores: opt: 226, E(): 2.7e-09, (32.1% identity
in 137 aa overlap); Rv0749, Rv0277c, Rv2530c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1242"
/db_xref="EnsemblGenomes-Tr:CCP43998"
/db_xref="GOA:P9WF69"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF69"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43998.1"
/translation="MIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPAL
FGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVDLLTAGPRHLDIALGLLDKLGTA
SHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE"
gene complement(1384989..1386677)
/gene="PE_PGRS23"
/locus_tag="Rv1243c"
CDS complement(1384989..1386677)
/codon_start=1
/transl_table=11
/gene="PE_PGRS23"
/locus_tag="Rv1243c"
/product="PE-PGRS family protein PE_PGRS23"
/note="Rv1243c, (MTV006.15c), len: 562 aa.
PE_PGRS23,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002)."
/db_xref="EnsemblGenomes-Gn:Rv1243c"
/db_xref="EnsemblGenomes-Tr:CCP43999"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FQ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP43999.1"
/translation="MEYLIAAQDVLVAAAADLEGIGSALAAANRAAEAPTTGLLAAGA
DEVSAAIASLFSGNAQAYQALSAQAAAFHQQFVRALSSAAGSYAAAEAANASPMQAVL
DVVNGPTQLLLGRPLIGDGANGGPGQNGGDGGLLYGNGGNGGSSSTPGQPGGRGGAAG
LIGNGGAGGAGGPGANGGAGGNGGWLYGNGGLGGNGGAATQIGGNGGNGGHGGNAGLW
GNGGAGGAGAAGAAGANGQNPVSHQVTHATDGADGTTGPDGNGTDAGSGSNAVNPGVG
GGAGGIGGDGTNLGQTDVSGGAGGDGGDGANFASGGAGGNGGAAQSGFGDAVGGNGGA
GGNGGAGGGGGLGGAGGSANVANAGNSIGGNGGAGGNGGIGAPGGAGGAGGNANQDNP
PGGNSTGGNGGAGGDGGVGASADVGGAGGFGGSGGRGGLLLGTGGAGGDGGVGGDGGI
GAQGGSGGNGGNGGIGADGMANQDGDGGDGGNGGDGGAGGAGGVGGNGGTGGAGGLFG
QSGSPGSGAAGGLGGAGGNGGAGGGGGTGFNPGAPGDPGTQGATGANGQHGLNG"
gene 1386857..1387717
/gene="lpqZ"
/locus_tag="Rv1244"
CDS 1386857..1387717
/codon_start=1
/transl_table=11
/gene="lpqZ"
/locus_tag="Rv1244"
/product="Probable lipoprotein LpqZ"
/note="Rv1244, (MTV006.16), len: 286 aa. Probable
lipoprotein lpqZ, equivalent toU15180|MLU1518042 protein
u1756x from Mycobacterium leprae (228 aa), FASTA scores:
opt: 1039, E(): 0, (72.5% identity in 229 aa overlap).
Similar to Mycobacterium tuberculosis hypothetical protein
Rv3759c. Contains PS00013 Prokaryotic membrane lipoprotein
lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1244"
/db_xref="EnsemblGenomes-Tr:CCP44000"
/db_xref="GOA:O50459"
/db_xref="InterPro:IPR007210"
/db_xref="UniProtKB/TrEMBL:O50459"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44000.1"
/translation="MRITRILALLLAVLLAVSGVAGCSADTGDRHPELVVGSTPDSEA
MLLAAIYVAALRSYGFAAHAETAADPVAKLDSGAFTVVPAFTGQMLQTLQPDASVRSD
AQVYRAIVSALPEGIAAGDYTTAAEDKPALVVTQSTAKAWGGGDLSELPSHCRGLLVG
RVAGAHTPAAVGPCRLPAPREFRNDATMFAALRAGQLVAAWTTTADPDIPADLIMLTD
GKPALIRAENIVPLYRRNALTERQLLAVNEVAGVLDTTALIGMRRQVAAGADPAAVAA
GWLAEHPLGR"
gene complement(1387798..1388628)
/locus_tag="Rv1245c"
CDS complement(1387798..1388628)
/codon_start=1
/transl_table=11
/locus_tag="Rv1245c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv1245c, (MTV006.17c), len: 276 aa. Probable
short-chain dehydrogenase/reductase, equivalent to
NP_301801.1|NC_002677 short chain alcohol dehydrogenase
from Mycobacterium leprae (277 aa). Also highly similar to
various dehydrogenases and oxidoreductases e.g.
NP_250228.1|NC_002516 probable short-chain dehydrogenase
from Pseudomonas aeruginosa (295 aa);
NP_421969.1|NC_002696 short chain dehydrogenase family
protein from Caulobacter crescentus (278 aa); etc. Also
highly similar to others from Mycobacterium tuberculosis
e.g. Rv3085|MTV013.06 probable short-chain type
dehydrogenase/reductase (276 aa),FASTA scores: opt: 368,
E(): 1.2e-16, (35.3% identity in 224 aa overlap);
Rv3057c|MTCY22D7.24 putative short chain alcohol
dehydrogenase/reductase (287 aa), FASTA scores: opt: 471,
E(): 1.3e-21, (32.4% identity in 281 aa overlap); etc.
Contains PS00061 Short-chain dehydrogenases/reductases
family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1245c"
/db_xref="EnsemblGenomes-Tr:CCP44001"
/db_xref="GOA:O50460"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O50460"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44001.1"
/translation="MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDGLA
DTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTGDIEVS
QFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLFSAPGQAAYNSAKF
AVRGFTEALRQEMALAGHPVKVTTVHPGGVKTAIARNATAAEGLDQAELAETFDKRVA
HLSPQRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFPIITGRLIPRPR
"
gene complement(1388685..1388978)
/gene="relE"
/gene_synonym="relE1"
/locus_tag="Rv1246c"
CDS complement(1388685..1388978)
/codon_start=1
/transl_table=11
/gene="relE"
/gene_synonym="relE1"
/locus_tag="Rv1246c"
/product="Toxin RelE"
/note="Rv1246c, (MTV006.18c), len: 97 aa. RelE, toxin,
part of toxin-antitoxin (TA) operon with Rv1247c (See
Pandey and Gerdes, 2005), highly similar to
Rv2866|MTV003.12 hypothetical Mycobacterium tuberculosis
protein (87 aa),FASTA scores: opt: 290, E(): 3.9e-24,
(54.1% identity in 85 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1246c"
/db_xref="EnsemblGenomes-Tr:CCP44002"
/db_xref="GOA:O50461"
/db_xref="InterPro:IPR007712"
/db_xref="InterPro:IPR035093"
/db_xref="UniProtKB/Swiss-Prot:O50461"
/protein_id="CCP44002.1"
/translation="MSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHR
LGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEIIHIARRSASYRMNPCRPR"
gene complement(1388975..1389244)
/gene="relB"
/gene_synonym="relB1"
/locus_tag="Rv1247c"
CDS complement(1388975..1389244)
/codon_start=1
/transl_table=11
/gene="relB"
/gene_synonym="relB1"
/locus_tag="Rv1247c"
/product="Antitoxin RelB"
/note="Rv1247c, (MTV006.19c), len: 89 aa. RelB,
antitoxin,part of toxin-antitoxin (TA) operon with Rv1246c
(See Pandey and Gerdes, 2005), some similarity to
hypothetical proteins including Mycobacterium tuberculosis
proteins Rv2865|MTV003.11 (93 aa), FASTA scores: opt: 249,
E(): 5.4e-13, (44.2% identity in 86 aa overlap);
Rv0268|Z86089|P95225 (169 aa) opt: 125, E(): 0.0089,
(41.8% identity in 55 aa overlap); etc. and Escherichia
coli AE000293|ECAE0002933 (92 aa), FASTA scores: opt: 127,
E(): 0.0038, (29.3% identity in 82 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1247c"
/db_xref="EnsemblGenomes-Tr:CCP44003"
/db_xref="GOA:O50462"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:O50462"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44003.1"
/translation="MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADD
LASIEETLEVLRTPGASEAIREGLADVAAGRFVSNDEIRNRYTAR"
gene complement(1389357..1393052)
/locus_tag="Rv1248c"
CDS complement(1389357..1393052)
/codon_start=1
/transl_table=11
/locus_tag="Rv1248c"
/product="Multifunctional alpha-ketoglutarate metabolic
enzyme"
/note="Rv1248c, (MTV006.20c), len: 1231 aa.
Multifunctional alpha-ketoglutarate metabolic enzyme,
highly similar to D84102 Corynebacterium glutamicum (1257
aa), FASTA scores: opt: 4418, E(): 0, (59.4% identity in
1223 aa overlap). Cofactor: thiamine diphosphate. Start
changed since first submission (+17 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1248c"
/db_xref="EnsemblGenomes-Tr:CCP44004"
/db_xref="GOA:P9WIS5"
/db_xref="InterPro:IPR001017"
/db_xref="InterPro:IPR001078"
/db_xref="InterPro:IPR005475"
/db_xref="InterPro:IPR011603"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR031717"
/db_xref="InterPro:IPR032106"
/db_xref="InterPro:IPR042179"
/db_xref="UniProtKB/Swiss-Prot:P9WIS5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44004.1"
/translation="MANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSPEP
TSQPAAEPTRVTSPLVAERAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGD
EVAVLRGAAAAVVKNMSASLEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFT
HLLGYALVQAVKKFPNMNRHYTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGI
KRCETMRFAQFVTAYEDIVRRARDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQ
GAIIGVGAMEYPAEFQGASEERIAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHEL
LLSDGFWDEVFRELSIPYLPVRWSTDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPL
RLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIG
VEYAHILDPEQKEWLEQRVETKHVKPTVAQQKYILSKLNAAEAFETFLQTKYVGQKRF
SLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGN
LNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQD
LLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNN
QIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACVWVARLAVDFRQRFKKDVV
IDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTEALIGRGDISMKEAEDALR
DYQGQLERVFNEVRELEKHGVQPSESVESDQMIPAGLATAVDKSLLARIGDAFLALPN
GFTAHPRVQPVLEKRREMAYEGKIDWAFGELLALGSLVAEGKLVRLSGQDSRRGTFSQ
RHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPD
AVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSARIE
RFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRHKAAVSEIKD
FTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDLAIVRLEQ
LAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIKRISR
RAMSAPSSGSSKVHAVEQQEILDEAFG"
gene complement(1393194..1393982)
/locus_tag="Rv1249c"
CDS complement(1393194..1393982)
/codon_start=1
/transl_table=11
/locus_tag="Rv1249c"
/product="Possible membrane protein"
/note="Rv1249c, (MTV006.21c), len: 262 aa. Possible
membrane protein. Start uncertain. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1249c"
/db_xref="EnsemblGenomes-Tr:CCP44005"
/db_xref="GOA:O50464"
/db_xref="UniProtKB/TrEMBL:O50464"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44005.1"
/translation="MSARRIRSWKRFDNRSANAAEPDPQLAGTGGRPKVSTRALAQVI
ERSSRIQGPAAQAYVARLRRAHPGASPAKIVAKLEKRFLSVVTASGAAVGAAATLPGI
GTLAAWFAAAGEVVVFLEATALFVLALASVHAIPLDHRERRRALVLAVLVGDNTTAVA
DLLGPGRTSGGWVSETMASLPLPAISSLNSRMLKYVVKRFALKRGALMFGKLVPMGIG
AIIGAIGNRLVGKKLVRNARSAFGTPPARWPVTLHVLPTVRDAS"
gene 1394179..1395918
/locus_tag="Rv1250"
CDS 1394179..1395918
/codon_start=1
/transl_table=11
/locus_tag="Rv1250"
/product="Probable drug-transport integral membrane
protein"
/note="Rv1250, (MTV006.22), len: 579 aa. Probable
drug-transport integral membrane protein, member of major
facilitator superfamily (MFS), highly similar to several
including P39886|TCMA_STRGA tetracenomycin C resistance
protein from Streptomyces glaucescens (538 aa), FASTA
scores: opt: 847, E(): 0, (32.9% identity in 517 aa
overlap); etc. Also similar to MTCY20B11.14c|Rv3239C from
Mycobacterium tuberculosis (1048 aa), FASTA scores: opt:
629, E(): 6.7e-13, (31.9% identity in 423 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1250"
/db_xref="EnsemblGenomes-Tr:CCP44006"
/db_xref="GOA:P9WG87"
/db_xref="InterPro:IPR004638"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WG87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44006.1"
/translation="MTTAIRRAAGSSYFRNPWPALWAMMVGFFMIMLDSTVVAIANPT
IMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCG
LSSGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAWGTVASVASLVGP
LAGGALVDSMGWEWIFFVNVPVGVIGLILAAYLIPALPHHPHRFDWFGVGLSGAGMFL
IVFGLQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSLSN
LRIAIIAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAPFVGMIIDRSH
PLCVLGFGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNL
RPHLAGASSGVFNAVRQLGAVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQ
LPEFVREPFAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDD
YVEYILRREPEEDCDTQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRA
WQADTESTAPSAL"
gene complement(1395821..1399240)
/locus_tag="Rv1251c"
CDS complement(1395821..1399240)
/codon_start=1
/transl_table=11
/locus_tag="Rv1251c"
/product="Conserved hypothetical protein"
/note="Rv1251c, (MTV006.23c), len: 1139 aa. Conserved
hypothetical protein, showing some similarity in
C-terminal region with other proteins from eukaryotes and
bacteria e.g. NP_142121.1 hypothetical protein from
Pyrococcus horikoshii (1188 aa); and some similarity to
GTP-binding proteins e.g. P23249|MV10_MOUSE putative
GTP-binding protein (1004 aa), FASTA scores: opt: 228,
E(): 1.7e-06,(27.7% identity in 560 aa overlap). Contains
PS00017 ATP/GTP-binding site motif A (P-loop). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1251c"
/db_xref="EnsemblGenomes-Tr:CCP44007"
/db_xref="InterPro:IPR019993"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR038720"
/db_xref="InterPro:IPR041679"
/db_xref="UniProtKB/TrEMBL:O50466"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44007.1"
/translation="MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDE
LMARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPV
VYQAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPV
AADAELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFR
CPQCTERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLT
AQAKLQIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYL
FGVLEAGRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALL
RLVGRYGIGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGD
VTTAADSINSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEA
GVTPIGAQPVPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRRE
DKPFWWAHFDRLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELAR
GDLNGNVFALYEPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTGSDGNTF
QQLPFALAPGPPVPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAAL
PRSSDPVTDIAAAALDLDSSYLAVHGPPGTGKTYTAARVIAELVTEHAWRIGVVAQSH
ATVENLLEGVISAGLDPGQVAKKPHDHTAGRWQSIDGSQYTEFIRDTAGCVIGGTAWD
FANGNRVPKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEP
VDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRR
LDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVL
APYNAQVALVRRRLASAGLGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGIS
FLLNRNRLNVAVSRAQYAAVIVRSELLTQYLPATPDGLVDLGAFLGLTSTS"
gene complement(1399296..1399904)
/gene="lprE"
/locus_tag="Rv1252c"
CDS complement(1399296..1399904)
/codon_start=1
/transl_table=11
/gene="lprE"
/locus_tag="Rv1252c"
/product="Probable lipoprotein LprE"
/note="Rv1252c, (MTCY50.30), len: 202 aa. Probable
lipoprotein lprE, some similarity to Mycobacterium
tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA
scores: E(): 7e-05, (29.5% identity in 200 aa overlap).
Contains possible N-terminal signal sequence and
appropriately positioned prokaryotic lipoprotein lipid
attachment site (PS00013). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv1252c"
/db_xref="EnsemblGenomes-Tr:CCP44008"
/db_xref="GOA:P9WK49"
/db_xref="InterPro:IPR025971"
/db_xref="UniProtKB/Swiss-Prot:P9WK49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44008.1"
/translation="MPGVWSPPCPTTPRVGVVAALVAATLTGCGSGDSTVAKTPEATP
SLSTAHPAPPSSEPSPPSATAAPPSNHSAAPVDPCAVNLASPTIAKVVSELPRDPRSE
QPWNPEPLAGNYNECAQLSAVVIKANTNAGNPTTRAVMFHLGKYIPQGVPDTYGFTGI
DTSQCTGDTVALTYASGIGLNNVVKFRWNGGGVELIGNTTGG"
gene 1399970..1401661
/gene="deaD"
/locus_tag="Rv1253"
CDS 1399970..1401661
/codon_start=1
/transl_table=11
/gene="deaD"
/locus_tag="Rv1253"
/product="Probable cold-shock DeaD-box protein A homolog
DeaD (ATP-dependent RNA helicase dead homolog)"
/note="Rv1253, (MTCY50.29c), len: 563 aa. Probable
deaD,Cold-shock dead-box protein A homolog, similar to
many e.g. DEAD_ECOLI|P23304 Escherichia coli (646 aa),
FASTA scores: opt: 1490, E(): 0, (46.7% identity in 578 aa
overlap); similar to Mycobacterium tuberculosis Rv3211.
Contains PS00017 ATP/GTP-binding site motif A, PS00039
dead-box subfamily ATP-dependent helicases signature.
Belongs to the dead box family helicase."
/db_xref="EnsemblGenomes-Gn:Rv1253"
/db_xref="EnsemblGenomes-Tr:CCP44009"
/db_xref="GOA:P9WH05"
/db_xref="InterPro:IPR000629"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR005580"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR012677"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR014014"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR028618"
/db_xref="InterPro:IPR034415"
/db_xref="UniProtKB/Swiss-Prot:P9WH05"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00039"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44009.1"
/translation="MAFPEYSPAASAATFADLQIHPRVLRAIGDVGYESPTAIQAATI
PALMAGSDVVGLAQTGTGKTAAFAIPMLSKIDITSKVPQALVLVPTRELALQVAEAFG
RYGAYLSQLNVLPIYGGSSYAVQLAGLRRGAQVVVGTPGRMIDHLERATLDLSRVDFL
VLDEADEMLTMGFADDVERILSETPEYKQVALFSATMPPAIRKLSAKYLHDPFEVTCK
AKTAVAENISQSYIQVARKMDALTRVLEVEPFEAMIVFVRTKQATEEIAEKLRARGFS
AAAISGDVPQAQRERTITALRDGDIDILVATDVAARGLDVERISHVLNYDIPHDTESY
VHRIGRTGRAGRSGAALIFVSPRELHLLKAIEKATRQTLTEAQLPTVEDVNTQRVAKF
ADSITNALGGPGIELFRRLVEEYEREHDVPMADIAAALAVQCRGGEAFLMAPDPPLSR
RNRDQRRDRPQRPKRRPDLTTYRVAVGKRHKIGPGAIVGAIANEGGLHRSDFGQIRIG
PDFSLVELPAKLPRATLKKLAQTRISGVLIDLRPYRPPDAARRHNGGKPRRKHVG"
gene 1401658..1402809
/locus_tag="Rv1254"
CDS 1401658..1402809
/codon_start=1
/transl_table=11
/locus_tag="Rv1254"
/product="Probable acyltransferase"
/note="Rv1254, (MTCY50.28c), len: 383 aa. Probable
Acyltransferase, similar to G927228 midecamycin
4-0-propionyl transferase (fragment) (388 aa), FASTA
scores, opt: 305, E(): 5.6e-14, (28.4% identity in 377 aa
overlap). Also similar to other Mycobacterium tuberculosis
acyltransferases e.g. Rv0111, Rv0228, etc. Contains
PS00881 Protein splicing signature."
/db_xref="EnsemblGenomes-Gn:Rv1254"
/db_xref="EnsemblGenomes-Tr:CCP44010"
/db_xref="GOA:Q11064"
/db_xref="InterPro:IPR002656"
/db_xref="UniProtKB/TrEMBL:Q11064"
/inference="protein motif:PROSITE:PS00881"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44010.1"
/translation="MTLPKERAAQGGLERIAHVDRVASLTGIRAVAALLVVGTHAAYT
TGKYTHGYWGLMSSRMEIGVPIFFVLSGFLLFRPWVKSAATGGPPPSLSRYAWHRVRR
IMPAYTVTVLLAYLVYHFRTAGPNPGHTWVGLFRNLTLTQIYTDGYLGAFLHQGLTQM
WSLAVEVAFYLALPALAYLLLVLVCRRRWQPRLLLATMAGLTMISPAWLILVHNTHWM
PDGARLWLPTYLAWFVGGMMLAVLAAMGVRCYAFVAIPLAVICYFIVSTPIAGAPTTS
PTALAEALVKTAFYAVIAVLAVAPLALGDQGWYAQLLASRPMVFLGEISYEIFLIHLV
TMEIAMVDVLGYRVYTSSMVNLCLVTLVLTIPLAWLLHRFTRVQGDRPS"
gene complement(1402778..1403386)
/locus_tag="Rv1255c"
CDS complement(1402778..1403386)
/codon_start=1
/transl_table=11
/locus_tag="Rv1255c"
/product="Probable transcriptional regulatory protein"
/note="Rv1255c, (MTCY50.27), len: 202 aa. Possible
regulatory protein, similar to others e.g.
ACRR_ECOLI|P34000 potential acrab operon repressor from E.
coli (215 aa), FASTA scores: opt: 128, E(): 0.25, (42.1%
identity in 57 aa overlap). Helix turn helix motif present
at aa 36-57 (+5.48 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1255c"
/db_xref="EnsemblGenomes-Tr:CCP44011"
/db_xref="GOA:P9WMD5"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/Swiss-Prot:P9WMD5"
/protein_id="CCP44011.1"
/translation="MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAA
GCSRATLYRYFDSREALRTAYVHRETRRLGREIMVKIADVVEPAERLLVSITTTLRMV
RDNPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRML
TSLLMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE"
gene complement(1403386..1404603)
/gene="cyp130"
/locus_tag="Rv1256c"
CDS complement(1403386..1404603)
/codon_start=1
/transl_table=11
/gene="cyp130"
/locus_tag="Rv1256c"
/product="Probable cytochrome P450 130 Cyp130"
/note="Rv1256c, (MT1295, MTCY50.26), len: 405 aa. Probable
cyp130, cytochrome P450, similar to other cytochromes
P-450 e.g. S51594 cytochrome P450 mycG from Micromonospora
griseorubida (397 aa); T36526 probable cytochrome P450
hydroxylase from Streptomyces coelicolor (411 aa);
CPXK_SACER|P33271|107B1 cytochrome P450 from
Saccharopolyspora erythraea (405 aa), FASTA scores: opt:
639, E(): 2.7e-33, (33.2% identity in 391 aa overlap);
etc. Also similar to others from Mycobacterium
tuberculosis e.g. Rv0766c|MTCY369.11c cytochrome P450 (402
aa); etc. Contains PS00086 Cytochrome P450 cysteine
heme-iron ligand signature. Belongs to the cytochrome P450
family."
/db_xref="EnsemblGenomes-Gn:Rv1256c"
/db_xref="EnsemblGenomes-Tr:CCP44012"
/db_xref="GOA:P9WPN5"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:2UUQ"
/db_xref="PDB:2UVN"
/db_xref="PDB:2WGY"
/db_xref="PDB:2WH8"
/db_xref="PDB:2WHF"
/db_xref="UniProtKB/Swiss-Prot:P9WPN5"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP44012.1"
/translation="MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEY
DYYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRK
LVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPE
EDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVA
AGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGI
PDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAE
LDVTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSY
VRRPLSVPFRVTS"
gene complement(1404717..1406084)
/locus_tag="Rv1257c"
CDS complement(1404717..1406084)
/codon_start=1
/transl_table=11
/locus_tag="Rv1257c"
/product="Probable oxidoreductase"
/note="Rv1257c, (MTCY50.25), len: 455 aa. Probable
oxidoreductase, similar to e.g. GLCD_ECOLI|P52075
glycolate oxidase subunit glcd (499 aa), FASTA scores:
E(): 0, (38.9% identity in 458 aa overlap). Similar to
Mycobacterium tuberculosis oxidoreductases e.g. Rv3107c"
/db_xref="EnsemblGenomes-Gn:Rv1257c"
/db_xref="EnsemblGenomes-Tr:CCP44013"
/db_xref="GOA:Q11061"
/db_xref="InterPro:IPR004113"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016164"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016171"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:Q11061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44013.1"
/translation="MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAI
IRPRRTEEVQTVLRWASANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMRDITVDPV
TRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTG
DYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNA
SSIVVASFGSVQAAVDAVLGVTGRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLV
AGSDERGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAARRFAIPAVESKGAL
LLEDVGVPLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERA
HLAYGEIMDLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQALDPQGILN
PGSAI"
gene complement(1406081..1407340)
/locus_tag="Rv1258c"
CDS complement(1406081..1407340)
/codon_start=1
/transl_table=11
/locus_tag="Rv1258c"
/product="Probable conserved integral membrane transport
protein"
/note="Rv1258c, MTCY50.24, len: 419 aa. Probable conserved
integral membrane transport (efflux) protein, possibly
member of major facilitator superfamily (MFS), highly
similar to O32859|tap protein multidrug-resistance efflux
pump from Mycobacterium fortuitum (409 aa), FASTA scores:
E(): 0, (68.4% identity in 408 aa overlap). Contains
PS00216 Sugar transport proteins signature 1."
/db_xref="EnsemblGenomes-Gn:Rv1258c"
/db_xref="EnsemblGenomes-Tr:CCP44014"
/db_xref="GOA:P9WJX9"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJX9"
/inference="protein motif:PROSITE:PS00216"
/protein_id="CCP44014.1"
/translation="MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQA
SIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVN
VLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAI
GGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRF
VWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGAL
GYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNY
VIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGL
VAIRLPALRELDLAPQADIDRPVGSAQ"
gene 1407339..1408238
/gene="udgB"
/locus_tag="Rv1259"
CDS 1407339..1408238
/codon_start=1
/transl_table=11
/gene="udgB"
/locus_tag="Rv1259"
/product="Probable uracil DNA glycosylase, UdgB"
/note="Rv1259, (MTCY50.23c), len: 299 aa. Probable
udgB,uracil DNA glycosylase. Similar to AL109732|SC7H2.04
hypothetical protein from Streptomyces coelicolor (237
aa),FASTA scores: opt: 870, E(): 0, (57.1% identity in 231
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1259"
/db_xref="EnsemblGenomes-Tr:CCP44015"
/db_xref="GOA:P9WM53"
/db_xref="InterPro:IPR005122"
/db_xref="InterPro:IPR036895"
/db_xref="UniProtKB/Swiss-Prot:P9WM53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44015.1"
/translation="MNIAAESSAKPVWGPPNFCAAAARMQDVRVLMHPKTGRAFRSPV
EPGSGWPGDPATPQTPVAADAAQVSALAGGAGSICELNALISVCRACPRLVSWREEVA
VVKRRAFADQPYWGRPVPGWGSKRPRLLILGLAPAAHGANRTGRMFTGDRSGDQLYAA
LHRAGLVNSPVSVDAADGLRANRIRITAPVRCAPPGNSPTPAERLTCSPWLNAEWRLV
SDHIRAIVALGGFAWQVALRLAGASGTPKPRFGHGVVTELGAGVRLLGCYHPSQQNMF
TGRLTPTMLDDIFREAKKLAGIE"
gene 1408240..1409358
/locus_tag="Rv1260"
CDS 1408240..1409358
/codon_start=1
/transl_table=11
/locus_tag="Rv1260"
/product="Probable oxidoreductase"
/note="Rv1260, (MTCY50.22c), len: 372 aa. Probable
oxidoreductase, highly similar to E1245747|AL021411
putative oxidoreductase SC7H1.18 from Streptomyces
coelicolor (397 aa), FASTA scores: E(): 1.4e-29, (45.9%
identity in 355 aa overlap); also some similarity to
G912582 FAD binding protein homologue from Pseudomonas
aeruginosa (286 aa), FASTA scores: opt: 245, E():
2e-09,(27.5% identity in 251 aa overlap);
PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537
aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity
in 360 aa overlap); TETX_BACFR|Q01911 tetracycline
resistance protein (388 aa),FASTA scores: opt: 183, E():
3e-05, (22.8% identity in 373 aa overlap). Also similar to
Mycobacterium tuberculosis hypothetical proteins Rv0575c
and Rv1751."
/db_xref="EnsemblGenomes-Gn:Rv1260"
/db_xref="EnsemblGenomes-Tr:CCP44016"
/db_xref="GOA:P9WM51"
/db_xref="InterPro:IPR002938"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WM51"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44016.1"
/translation="MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAID
VRGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGPVNSPDIEL
LRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAAREFDLVIGADGLHS
NVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTEAR
AALAFMDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILM
DRWSRGRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGDDYQLGFANYHAEF
HGFVERNQWLVSDNIPGGAPIPQEEFERIVHSITIKDY"
gene complement(1409484..1409933)
/locus_tag="Rv1261c"
CDS complement(1409484..1409933)
/codon_start=1
/transl_table=11
/locus_tag="Rv1261c"
/product="Conserved protein"
/note="Rv1261c, (MTCY50.21), len: 149 aa. Conserved
protein, similar to Mycobacterium tuberculosis
hypothetical proteins e.g. Rv1558|MTCY48.07c (39.2%
identity in 125 aa overlap); Rv3547 and Rv3178."
/db_xref="EnsemblGenomes-Gn:Rv1261c"
/db_xref="EnsemblGenomes-Tr:CCP44017"
/db_xref="GOA:P9WP13"
/db_xref="InterPro:IPR004378"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/Swiss-Prot:P9WP13"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44017.1"
/translation="MDISRWLERHVGVQLLRLHDAIYRGTNGRIGHRIPGAPPSLLLH
TTGAKTSQPRTTSLTYARDGDAYLIVASKGGDPRSPGWYHNLKANPDVEINVGPKRFG
VTAKPVQPHDPDYARLWQIVNENNANRYTNYQSRTSRPIPVVVLTRR"
gene complement(1409938..1410372)
/locus_tag="Rv1262c"
CDS complement(1409938..1410372)
/codon_start=1
/transl_table=11
/locus_tag="Rv1262c"
/product="Hypothetical hit-like protein"
/note="Rv1262c, (MTCY50.20), len: 144 aa. Hypothetical
hit-like protein, similar to Q04344|HIT_YEAST hit1 protein
(orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14,
(35.9 % identity in 142 aa overlap); also similar to
YHIT_MYCGE|P47378 hypothetical 15.6 kDa protein (141
aa),FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity
in 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical
17.0 kDa protein hit-like (155 aa), FASTA scores: opt:
196, E(): 7e-07, (30.6% identity in 144 aa overlap).
Similar to other proteins from Mycobacterium tuberculosis
e.g. Rv2613c,Rv0759c. Contains PS00892 hit family
signature. Belongs to the hit family."
/db_xref="EnsemblGenomes-Gn:Rv1262c"
/db_xref="EnsemblGenomes-Tr:CCP44018"
/db_xref="GOA:P9WML1"
/db_xref="InterPro:IPR001310"
/db_xref="InterPro:IPR011146"
/db_xref="InterPro:IPR019808"
/db_xref="InterPro:IPR036265"
/db_xref="InterPro:IPR039384"
/db_xref="UniProtKB/Swiss-Prot:P9WML1"
/inference="protein motif:PROSITE:PS00892"
/protein_id="CCP44018.1"
/translation="MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKR
HTVDLTDTPPEALADMVAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVL
PPRNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD"
gene 1410431..1411819
/gene="amiB2"
/locus_tag="Rv1263"
CDS 1410431..1411819
/codon_start=1
/transl_table=11
/gene="amiB2"
/locus_tag="Rv1263"
/product="Probable amidase AmiB2 (aminohydrolase)"
/note="Rv1263, (MTCY50.19c), len: 462 aa. Probable
amiB2,amidase. Similar to G1001278 hypothetical 54.3 kDa
protein (506 aa), FASTA scores: opt: 767, E(): 7.6e-40,
(32.8% identity in 461 aa overlap), also similar to
G580673 rhodococcus enantiose lective amidase gene (462
aa), FASTA scores, opt: 668, E(): 7.4e-34, (33.5% identity
in 484 aa overlap) also to NYLA_PSES8|P13398
6-aminohexanoate-cyclic-dimer hydrolase (492 aa), FASTA
scores opt: 543, E(): 3.1e-26, (33.5% identity in 493 aa
overlap). Also similar to MTCY274.19c (33.5% identity in
427 aa overlap). Similar to other putative amidases in M.
tuberculosis; Rv2363, Rv2888c, etc. Contains PS00017
ATP/GTP-binding site motif A. Belongs to the amidase
family."
/db_xref="EnsemblGenomes-Gn:Rv1263"
/db_xref="EnsemblGenomes-Tr:CCP44019"
/db_xref="GOA:P9WQ97"
/db_xref="InterPro:IPR000120"
/db_xref="InterPro:IPR020556"
/db_xref="InterPro:IPR023631"
/db_xref="InterPro:IPR036928"
/db_xref="UniProtKB/Swiss-Prot:P9WQ97"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44019.1"
/translation="MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLR
AYRVVQFDRARAEAEAAQQRLDAGERLPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAA
TSDAEVVRRLRAAGAVIIGKTNVPELMIMPFTESLAFGATRNPWCLNRTPGGSSGGSA
AAVAAGLAPVALGSDGGGSIRIPCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIA
RSVMDAALLLDATTTVPGPEGEFVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAV
HQAGALLRDLGHDVVVRDPDYPASTYANYLPRFFRGISDDADAQAHPDRLEARTRAIA
RLGSFFSDRRMAALRAAEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVST
LLLVVQRVPYFQVWNLTGQPAAVVPWDFDGDGLPMSVQLVGRPYDEATLLALAAQIES
ARPWAHRRPSVS"
gene 1411894..1413087
/locus_tag="Rv1264"
CDS 1411894..1413087
/codon_start=1
/transl_table=11
/locus_tag="Rv1264"
/product="Adenylyl cyclase (ATP pyrophosphate-lyase)
(adenylate cyclase)"
/note="Rv1264, (MTCY50.18c), len: 397 aa. Adenylate
cyclase (function proven experimentally: see Linder et
al., 2002),showing some similarity to other adenylate
cyclases e.g. CYAA_BRELI|P27580 (403 aa), FASTA scores,
opt: 270, E(): 1.3e-10, (29.3% identity in 317 aa
overlap); etc. Similar to other putative cyclases in M.
tuberculosis e.g. Rv2212,Rv1647. The C terminus seems to
code for a catalytic domain belonging to a subfamily of
adenylyl cyclase isozymes (mostly found in Gram-positive
bacteria). The N terminus seems to be a potential novel
regulator of adenylyl cyclase activity (autoinhibitory
domain). Belongs to the adenylyl cyclase class-4/guanylyl
cyclase family."
/db_xref="EnsemblGenomes-Gn:Rv1264"
/db_xref="EnsemblGenomes-Tr:CCP44020"
/db_xref="GOA:P9WMU9"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR032026"
/db_xref="PDB:1Y10"
/db_xref="PDB:1Y11"
/db_xref="PDB:2EV1"
/db_xref="PDB:2EV2"
/db_xref="PDB:2EV3"
/db_xref="PDB:2EV4"
/db_xref="UniProtKB/Swiss-Prot:P9WMU9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44020.1"
/translation="MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDE
IRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVV
HMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATE
LDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTV
AFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAP
LLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVL
VADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDL
AGSSP"
gene complement(1413094..1413224)
/gene="mcr11"
/gene_synonym="MTS0997"
ncRNA complement(1413094..1413224)
/gene="mcr11"
/gene_synonym="MTS0997"
/product="Putative small regulatory RNA"
/note="mcr11, putative small regulatory RNA (See DiChiara
et al., 2010). 5'-end mapped by RLM-RACE in M.
tuberculosis H37Rv, 3'-end not mapped (See Arnvig et al.,
2011)."
/ncRNA_class="other"
gene 1413260..1413940
/locus_tag="Rv1265"
CDS 1413260..1413940
/codon_start=1
/transl_table=11
/locus_tag="Rv1265"
/product="Unknown protein"
/note="Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein
(see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv1265"
/db_xref="EnsemblGenomes-Tr:CCP44021"
/db_xref="GOA:P9WM49"
/db_xref="UniProtKB/Swiss-Prot:P9WM49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44021.1"
/translation="MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMH
GRRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLES
PEEESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVP
VMTRLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLR
AQGPDLPA"
gene complement(1413960..1415840)
/gene="pknH"
/locus_tag="Rv1266c"
CDS complement(1413960..1415840)
/codon_start=1
/transl_table=11
/gene="pknH"
/locus_tag="Rv1266c"
/product="Probable transmembrane serine/threonine-protein
kinase H PknH (protein kinase H) (STPK H)"
/note="Rv1266c, (MTCY50.16), len: 626 aa. Probable
pknH,transmembrane serine/threonine-protein kinase (see
citation below), similar to many e.g. PKN1_MYXXA|P33973
pkn1 (693 aa), FASTA scores: opt: 611, E(): 1.4e- 14,
(29.7% identity in 492 aa overlap); etc. Contains PS00107
Protein kinases ATP-binding region signature; PS00108
Serine/Threonine protein kinases active-site signature.
Contains Hank's kinase subdomain. Belongs to the Ser/Thr
family of protein kinases. Experimental studies show
evidence of auto-phosphorylation."
/db_xref="EnsemblGenomes-Gn:Rv1266c"
/db_xref="EnsemblGenomes-Tr:CCP44022"
/db_xref="GOA:P9WI71"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR026954"
/db_xref="InterPro:IPR038232"
/db_xref="PDB:4ESQ"
/db_xref="UniProtKB/Swiss-Prot:P9WI71"
/inference="protein motif:PROSITE:PS00108"
/inference="protein motif:PROSITE:PS00107"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44022.1"
/translation="MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAV
KLMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLD
SVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGI
ASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRAD
SAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEAL
SDPDQDHAADILRRSQESTLPAPPKPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKP
SYTPPAQPGPAGQRPGPTGQPSWAPNSGPMPASGPTPTPQYYQGGGWGAPPSGGPSPW
AQTPRKTNPWPLVAGAAAVVLVLVLGAIGIWIAIRPKPVQPPQPVAEERLSALLLNSS
EVNAVMGSSSMQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISS
EPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKAKTYRWTFADV
KGSPPTITVIDTQEGAEGWECQRAMSVANNVVVDVNACGYRITNQAGQIAAKIVDKVN
KE"
gene complement(1416181..1417347)
/gene="embR"
/locus_tag="Rv1267c"
CDS complement(1416181..1417347)
/codon_start=1
/transl_table=11
/gene="embR"
/locus_tag="Rv1267c"
/product="Probable transcriptional regulatory protein
EmbR"
/note="Rv1267c, (MT1305, MTCY50.15), len: 388 aa. Probable
embR, regulatory protein (see citation below), similar to
many e.g. AFSR_STRCO|P25941 regulatory protein AfsR from
Streptomyces coelicolor (993 aa), FASTA scores: opt:
489,E(): 1e-25, (33.5% identity in 361 aa overlap); etc.
Belongs to the AFSR/DNRI/REDD family of regulators.
Phosphorylated in vitro by PknJ|Rv2088 (See Jang et
al.,2010)."
/db_xref="EnsemblGenomes-Gn:Rv1267c"
/db_xref="EnsemblGenomes-Tr:CCP44023"
/db_xref="GOA:P9WGJ9"
/db_xref="InterPro:IPR000253"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR005158"
/db_xref="InterPro:IPR008984"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="PDB:2FEZ"
/db_xref="PDB:2FF4"
/db_xref="UniProtKB/Swiss-Prot:P9WGJ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44023.1"
/translation="MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVI
NRNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYR
LSIPDNTCDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVE
PFATALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLS
DRQSDALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTV
LDQRTMASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVD
TGTNYVINDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT"
gene complement(1417658..1418356)
/locus_tag="Rv1268c"
CDS complement(1417658..1418356)
/codon_start=1
/transl_table=11
/locus_tag="Rv1268c"
/product="Hypothetical protein"
/note="Rv1268c, (MTCY50.14), len: 232 aa. Hypothetical
unknown protein, probably secreted protein : contains
possible signal peptide sequence (score 7.9 at residue
28). Predicted to be an outer membrane protein (See Song
et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1268c"
/db_xref="EnsemblGenomes-Tr:CCP44024"
/db_xref="InterPro:IPR025660"
/db_xref="InterPro:IPR039564"
/db_xref="UniProtKB/Swiss-Prot:P9WM47"
/protein_id="CCP44024.1"
/translation="MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAA
AKYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAE
HPNSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSI
NAEMIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFV
EAWATSHDFMAVTT"
gene complement(1418579..1418953)
/locus_tag="Rv1269c"
CDS complement(1418579..1418953)
/codon_start=1
/transl_table=11
/locus_tag="Rv1269c"
/product="Conserved probable secreted protein"
/note="Rv1269c, (MTCY50.13), len: 124 aa. Conserved
probable exported protein with putative N-terminal signal
sequence. Similar to Mycobacterium tuberculosis protein
Rv1813c|Y0DU_MYCTU|Q50620 hypothetical protein cy1a11.30
(137 aa), FASTA scores: E(): 9e-21, (41.6% identity in 137
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1269c"
/db_xref="EnsemblGenomes-Tr:CCP44025"
/db_xref="GOA:P9WM45"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR025240"
/db_xref="UniProtKB/Swiss-Prot:P9WM45"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44025.1"
/translation="MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAY
SGNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTL
AAAMKDALTKLGGGYIDTWACN"
gene complement(1419014..1419748)
/gene="lprA"
/locus_tag="Rv1270c"
CDS complement(1419014..1419748)
/codon_start=1
/transl_table=11
/gene="lprA"
/locus_tag="Rv1270c"
/product="Possible lipoprotein LprA"
/note="Rv1270c, (MTCY50.12), len: 244 aa. Possible
lprA,lipoprotein. Similar to O32852|AJ000500 lipoprotein
from Mycobacterium bovis (236 aa), fasta scores: E():
5.2e-23,(35.1% identity in 245 aa overlap). Similar to M.
tuberculosis lipoproteins: Rv1368, Rv1411c, Rv2945c.
Contains probable N-terminal signal sequence."
/db_xref="EnsemblGenomes-Gn:Rv1270c"
/db_xref="EnsemblGenomes-Tr:CCP44026"
/db_xref="GOA:P9WK55"
/db_xref="InterPro:IPR009830"
/db_xref="InterPro:IPR029046"
/db_xref="UniProtKB/Swiss-Prot:P9WK55"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44026.1"
/translation="MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKASDTAATASNG
DAAMLLKQATDAMRKVTGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVG
NKSEDAKFVYVDGHLYSDLGQPGTYTDFGNGASIYNVSVLLDPNKGLANLLANLKDAS
VAGSQQADGVATTKITGNSSADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQ
IAPTKDTSVTLTMSDWGKQVTATKPV"
gene complement(1419961..1420302)
/locus_tag="Rv1271c"
CDS complement(1419961..1420302)
/codon_start=1
/transl_table=11
/locus_tag="Rv1271c"
/product="Conserved hypothetical secreted protein"
/note="Rv1271c, (MTCY50.11), len: 113 aa. Conserved
hypothetical exported protein with potential N-terminal
signal sequence. Similar to Mycobacterium tuberculosis
hypothetical proteins Rv1804c, Rv1810, Rv0622, etc."
/db_xref="EnsemblGenomes-Gn:Rv1271c"
/db_xref="EnsemblGenomes-Tr:CCP44027"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/Swiss-Prot:P9WM43"
/protein_id="CCP44027.1"
/translation="MLSPLSPRIIAAFTTAVGAAAIGLAVATAGTAGANTKDEAFIAQ
MESIGVTFSSPQVATQQAQLVCKKLASGETGTEIAEEVLSQTNLTTKQAAYFVVDATK
AYCPQYASQLT"
gene complement(1420410..1422305)
/locus_tag="Rv1272c"
CDS complement(1420410..1422305)
/codon_start=1
/transl_table=11
/locus_tag="Rv1272c"
/product="Probable drugs-transport transmembrane
ATP-binding protein ABC transporter"
/note="Rv1272c, (MTCY50.10), len: 631 aa. Probable
drugs-transport transmembrane ATP-binding protein ABC
transporter (see citation below), similar to e.g.
Y015_MYCGE|P47261 hypothetical ABC transporter mg015m from
Mycoplasma genitalium (589 aa), FASTA scores: opt:
1054,E(): 0, (34.3% identity in 522 aa overlap); etc.
Contains PS00017 ATP/GTP-binding site motif A (P-loop);
and PS00211 ABC transporters family signature. Belongs to
the ATP-binding transport protein family (ABC
transporters),MSBA subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1272c"
/db_xref="EnsemblGenomes-Tr:CCP44028"
/db_xref="GOA:P9WQJ3"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="InterPro:IPR039421"
/db_xref="UniProtKB/Swiss-Prot:P9WQJ3"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44028.1"
/translation="MTAPPGARPRAASPPPNMRSRDFWGSAARLVKRLAPQRRLSIAV
ITLGIAGTTIGVIVPRILGHATDLLFNGVIGRGLPGGITKAQAVASARARGDNTFADL
LSGMNVVPGQGVDFAAVERTLALALALYLAAALMIWAQARLLNLTVQKTMVRLRTDVE
DKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTISQLVTSILTMVAVLAMMVSI
SGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLNAHLEETYSGFTVVKTFG
HQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYVAVAVAGGLQVATGQI
TLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDEPEESPEPEPELPN
LTGRVEFEHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTGAGKTTLVNLLMRFYEIG
SGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGRPEATTDEIVEAAR
AAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLLILDEATSSVDT
RTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNHAELLARRGV
YYQMTRA"
gene complement(1422302..1424050)
/locus_tag="Rv1273c"
CDS complement(1422302..1424050)
/codon_start=1
/transl_table=11
/locus_tag="Rv1273c"
/product="Probable drugs-transport transmembrane
ATP-binding protein ABC transporter"
/note="Rv1273c, (MTCY50.09), len: 582 aa. Probable
drugs-transport transmembrane ATP-binding protein ABC
transporter (see citation below), similar to e.g.
YWJA_BACSU|P45861 hypothetical abc transporter from B.
subtilis (575 aa), FASTA scores: opt: 810, E(): 0, (27.0%
identity in 578 aa overlap); etc. Contains PS00136 Serine
proteases, subtilase family, aspartic acid active site; 2
x PS00211 ABC transporters family signature; and PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
ATP-binding transport protein family (ABC
transporters),MSBA subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1273c"
/db_xref="EnsemblGenomes-Tr:CCP44029"
/db_xref="GOA:P9WQJ1"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="InterPro:IPR039421"
/db_xref="UniProtKB/Swiss-Prot:P9WQJ1"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00136"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44029.1"
/translation="MLLALLRQHIRPYRRLVAMLMMLQLVSTLASLYLPTVNAAIVDD
GVAKGDTATIVRLGAVMLGVTGLQVLCAIGAVYLGSRTGAGFGRDLRSAMFEHIITFS
ERETARFGAPTLLTRSTNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWL
LLVSVPILAVANYWIISHMLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERD
KFAQANTALSNAALSAGNWQALMLPVTTLTINASSVALIWFGGLRIDSGQMQVGSLIA
FLSYFAQILMAVLMATMTLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGV
VRLAGATFTYPGADCPVLQDISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGA
VLVDGIDVREYHTERLWSAIGLVPQRSYLFSGTVADNLRYGGGPDQVVTEQEMWEALR
VAAADGFVQTDGLQTRVAQGGVNFSGGQRQRLAIARAVIRRPAIYVFDDAFSALDVHT
DAKVHASLRQVSGDATIIVVTQRISNAAQADQVIVVDNGKIVGTGTHETLLADCPTYA
EFAASQSLSATVGGVG"
gene 1424197..1424754
/gene="lprB"
/locus_tag="Rv1274"
CDS 1424197..1424754
/codon_start=1
/transl_table=11
/gene="lprB"
/locus_tag="Rv1274"
/product="Possible lipoprotein LprB"
/note="Rv1274, (MTCY50.08c), len: 185 aa. Possible
lprB,lipoprotein; contains possible N-terminal signal
sequence and appropriately positioned prokaryotic
lipoprotein lipid attachment site (PS00013). Some
similarity to Rv1275. A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1274"
/db_xref="EnsemblGenomes-Tr:CCP44030"
/db_xref="GOA:P9WK53"
/db_xref="InterPro:IPR024520"
/db_xref="UniProtKB/Swiss-Prot:P9WK53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44030.1"
/translation="MRRKVRRLTLAVSALVALFPAVAGCSDSGDNKPGATIPSTPANA
EGRHGPFFPQCGGVSDQTVTELTRVTGLVNTAKNSVGCQWLAGGGILGPHFSFSWYRG
SPIGRERKTEELSRASVEDINIDGHSGFIAIGNEPSLGDSLCEVGIQFSDDFIEWSVS
FSQKPFPLPCDIAKELTRQSIANSK"
gene 1424751..1425293
/gene="lprC"
/locus_tag="Rv1275"
CDS 1424751..1425293
/codon_start=1
/transl_table=11
/gene="lprC"
/locus_tag="Rv1275"
/product="Possible lipoprotein LprC"
/note="Rv1275, (MTCY50.07c), len: 180 aa. Possible
lprC,lipoprotein; contains possible N-terminal signal
sequence and appropriately positioned prokaryotic
lipoprotein lipid attachment site (PS00013). Some
similarity to Rv1274. A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1275"
/db_xref="EnsemblGenomes-Tr:CCP44031"
/db_xref="GOA:O86337"
/db_xref="InterPro:IPR024520"
/db_xref="UniProtKB/TrEMBL:O86337"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44031.1"
/translation="MRRVLVGAAALITALLVLTGCTKSISGTAVKAGGAGVPRNNNSQ
ERYPNLLKECEVLTTDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQ
GSLSNERKVAEGLKYQVETRAIQGVDSIVMRTGDPNGACGVASDAAGVVGWWVNPQAP
GIDACGQAIKLMELTLATNA"
gene complement(1425438..1425914)
/locus_tag="Rv1276c"
CDS complement(1425438..1425914)
/codon_start=1
/transl_table=11
/locus_tag="Rv1276c"
/product="Conserved hypothetical protein"
/note="Rv1276c, (MTCY50.06), len: 158 aa. Conserved
hypothetical protein, similar to AL096844|SCI28.03
hypothetical protein from Streptomyces coelicolor (172
aa),FASTA scores: opt: 385, E(): 3.3e-19, (43.5% identity
in 161 aa overlap). Some similarity to P76502|SIXA_ECOLI
phosphohistidine phosphatase SIXA (161 aa), FASTA scores:
opt: 146, E(): 0.0047, (31.9% identity in 116 aa overlap).
Belongs to the SixA family of phosphatases."
/db_xref="EnsemblGenomes-Gn:Rv1276c"
/db_xref="EnsemblGenomes-Tr:CCP44032"
/db_xref="GOA:P9WGF9"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="UniProtKB/Swiss-Prot:P9WGF9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44032.1"
/translation="MRHAKSAYPDGIADHDRPLAPRGIREAGLAGGWLRANLPAVDAV
LCSTATRARQTLAHTGIDAPARYAERLYGAAPGTVIEEINRVGDNVTTLLVVGHEPTT
SALAIVLASISGTDAAVAERISEKFPTSGIAVLRVAGHWADVEPGCAALVGFHVPR"
gene 1426164..1427417
/locus_tag="Rv1277"
CDS 1426164..1427417
/codon_start=1
/transl_table=11
/locus_tag="Rv1277"
/product="Conserved hypothetical protein"
/note="Rv1277, (MTCY50.05c), len: 417 aa. Conserved
hypothetical protein, some similarity to
3914967|O68033|SBCD_RHOCA exonuclease SBCD homolog from
Rhodobacter capsulatus (405 aa). May be sbcD protein (see
Mizrahi & Andersen 1998)"
/db_xref="EnsemblGenomes-Gn:Rv1277"
/db_xref="EnsemblGenomes-Tr:CCP44033"
/db_xref="GOA:Q50699"
/db_xref="InterPro:IPR004843"
/db_xref="InterPro:IPR014577"
/db_xref="InterPro:IPR029052"
/db_xref="InterPro:IPR041796"
/db_xref="UniProtKB/TrEMBL:Q50699"
/protein_id="CCP44033.1"
/translation="MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQ
LGMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQ
SLEAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQI
VAAPWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDA
LTRQAIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPR
HPVTVDARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTD
RAALDTCLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARG
GDDESAVDAQAALALLLRLADRGAA"
gene 1427414..1430041
/locus_tag="Rv1278"
CDS 1427414..1430041
/codon_start=1
/transl_table=11
/locus_tag="Rv1278"
/product="Hypothetical protein"
/note="Rv1278, (MTCY50.04c), len: 875 aa. Hypothetical
unknown protein, possible coiled-coil regions, contains
PS00017 ATP/GTP-binding site motif A. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1278"
/db_xref="EnsemblGenomes-Tr:CCP44034"
/db_xref="GOA:P9WM41"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041685"
/db_xref="UniProtKB/Swiss-Prot:P9WM41"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44034.1"
/translation="MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEAL
DLLLEYKDRSTKKEVKQVKPTNADVGSEVIAEISSGPYRFVYRKRFHKRCETELTVLA
PRREQLTGDEAHERVRTMLAETVDTELWHAQRVLQAASTAAVDLSGCDALSRALDLAA
GDDAALSGTESLLIERIEAEYARYFTPTGRPTGEWSAAVSRLAAAEAAVADCAAAVAE
VDDGVRRHTELTEQVAELSQQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAA
TSGASTAAHAGRLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEAT
QVLTAVRLRAESARRTLDQLADCEEADRLAARLARIDDIEGDRDRVCAELSAVTLTEE
LLSRIERAAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVSLSAGQSWSVTATGP
TEVKVPGVLTARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRREL
LSRRDQLTATLAGLCGDEQVDQLRSRLEQLCAGQPAELDLVSTDTATARAELDAVEAA
RIAAEKDCETRRQIAAGAARRLAETSTRATVLQNAAAAESAELGAAMTRLACERASVG
DDELAAKAEADLRVLQTAEQRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEA
IRALHEVGVELSVFGTQGRKGKLDAAETEREHAASHHARVGRRARAARLLRSVMARHR
DTTRLRYVEPYRAELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGGAKE
QLGILARLAGAALVAKEDAVPVLIDDALGFTDPERLAKMGEVFDTIGADGQVIVLTCS
PTRYGGVKGAHRIDLDAIQ"
gene 1430062..1431648
/locus_tag="Rv1279"
CDS 1430062..1431648
/codon_start=1
/transl_table=11
/locus_tag="Rv1279"
/product="Probable dehydrogenase FAD flavoprotein GMC
oxidoreductase"
/note="Rv1279, (MTCY50.03c), len: 528 aa. Probable
dehydrogenase, FAD flavoprotein GMC oxidoreductase,
similar to several e.g. dBETA_ECOLI|P17444 choline
dehydrogenase from Escherichia coli (556 aa), FASTA
scores, opt: 1047,E(): 0, (37.7% identity in 541 aa
overlap). Similar to Rv0697 putative Mycobacterium
tuberculosis GMC oxidoreductase. Contains PS00623 GMC
oxidoreductases signature 1, and PS00624 GMC
oxidoreductases signature 2. Belongs to the GMC
oxidoreductases family."
/db_xref="EnsemblGenomes-Gn:Rv1279"
/db_xref="EnsemblGenomes-Tr:CCP44035"
/db_xref="GOA:P9WMV5"
/db_xref="InterPro:IPR000172"
/db_xref="InterPro:IPR007867"
/db_xref="InterPro:IPR012132"
/db_xref="InterPro:IPR027424"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WMV5"
/inference="protein motif:PROSITE:PS00623"
/inference="protein motif:PROSITE:PS00624"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44035.1"
/translation="MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRF
IGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASD
YDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTA
AWLAAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTG
ATATRVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLA
EHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNV
GEAYGFVRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLR
SADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTEL
DEATLELALATCSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVR
GHTHAPSVLIGEKAADLIRS"
gene complement(1431665..1433440)
/gene="oppA"
/locus_tag="Rv1280c"
CDS complement(1431665..1433440)
/codon_start=1
/transl_table=11
/gene="oppA"
/locus_tag="Rv1280c"
/product="Probable periplasmic oligopeptide-binding
lipoprotein OppA"
/note="Rv1280c, (MTCY50.02), len: 591 aa. Probable
oppA,oligopeptide-binding lipoprotein component of peptide
transport system (see citation below), sharing some
similarity to other periplasmic solute binding proteins
e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding
protein from Salmonella typhimurium (542 aa), FASTA
scores: E(): 5.1e-05, (22.1% identity in 458 aa overlap);
etc. Also similar to Rv1166 and Rv2585c from Mycobacterium
tuberculosis. Has possible N-terminal signal sequence and
prokaryotic lipoprotein lipid attachment site (PS00013).
Belongs to the bacterial extracellular solute-binding
protein family 5."
/db_xref="EnsemblGenomes-Gn:Rv1280c"
/db_xref="EnsemblGenomes-Tr:CCP44036"
/db_xref="GOA:P9WGU5"
/db_xref="InterPro:IPR000914"
/db_xref="InterPro:IPR030678"
/db_xref="InterPro:IPR039424"
/db_xref="UniProtKB/Swiss-Prot:P9WGU5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44036.1"
/translation="MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLV
VAMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNF
NILHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINP
EAVWSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAK
PYAEWRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTR
NPRWWGARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRA
PGPSWYHFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVA
GQDGYQDNSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFA
QIAQHTLAQIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASD
GESNFGKIGSPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAV
RSTLANFGATGLADLDYTAIGFMRR"
gene complement(1433433..1435271)
/gene="oppD"
/locus_tag="Rv1281c"
CDS complement(1433433..1435271)
/codon_start=1
/transl_table=11
/gene="oppD"
/locus_tag="Rv1281c"
/product="Probable oligopeptide-transport ATP-binding
protein ABC transporter OppD"
/note="Rv1281c, (MTCY50.01), len: 612 aa. Probable
oppD,oligopeptide-transport ATP-binding protein ABC
transporter (see citation below), similar to others e.g.
DPPD_BACSU|P26905 dipeptide transport ATP-binding protein
from Bacillus subtilis (335 aa), FASTA scores: opt:
983,E(): 0, (48.6% identity in 319 aa overlap); etc.
Contains 2 x PS00017 ATP/GTP-binding site motif A
(P-loop); 2 x PS00211 ABC transporters family signature.
Belongs to the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1281c"
/db_xref="EnsemblGenomes-Tr:CCP44037"
/db_xref="GOA:P9WQJ5"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR013563"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQJ5"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44037.1"
/translation="MSPLLEVTDLAVTFRTDGDPVTAVRGISYRVEPGEVVAMVGESG
SGKSAAAMAVVGLLPEYAQVRGSVRLQGTELLGLADNAMSRFRGKAIGTVFQDPMSAL
TPVYTVGDQIAEAIEVHQPRVGKKAARRRAVELLDLVGISQPQRRSRAFPHELSGGER
QRVVIAIAIANDPDLLICDEPTTALDVTVQAQILDVLKAARDVTGAGVLIITHDLGVV
AEFADRALVMYAGRVVESAGVNDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAP
PSLAGLAPGCPFAPRCPLVIDECLTAEPELLDVATDHRAACIRTELVTGRSAADIYRV
KTEARPAALGDASVVVRVRHLVKTYRLAKGVVLRRAIGEVRAVDGISLELRQGRTLGI
VGESGSGKSTTLHEILELAAPQSGSIEVLGTDVATLGTAERRSLRRDIQVVFQDPVAS
LDPRLPVFDLIAEPLQANGFGKNETHARVAELLDIVGLRHGDASRYPAEFSGGQKQRI
GIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQEQFGLSYLFVSHDLSVVKHL
AHQVAVMLAGTVVEQGDSEEVFGNPKHEYTRRLLGAVPQPDPARRG"
gene complement(1435268..1436143)
/gene="oppC"
/locus_tag="Rv1282c"
CDS complement(1435268..1436143)
/codon_start=1
/transl_table=11
/gene="oppC"
/locus_tag="Rv1282c"
/product="Probable oligopeptide-transport integral
membrane protein ABC transporter OppC"
/note="Rv1282c, (MTCY373.01c-MTCY3H3.01), len: 291 aa.
Probable oppC, oligopeptide-transport integral membrane
protein ABC transporter (see Braibant et al.,
2000),similar to other integral membrane proteins e.g.
OPPC_ECOLI|P77664 oligopeptide transport system permease
from Escherichia coli (302 aa), FASTA scores: E():
4.6e-33,(40.7% identity in 275 aa overlap); etc. Also
similar to Rv3664c|DPPC probable peptide-transport
integral membrane protein from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv1282c"
/db_xref="EnsemblGenomes-Tr:CCP44038"
/db_xref="GOA:P9WFZ9"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR025966"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WFZ9"
/protein_id="CCP44038.1"
/translation="MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPY
SYDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATV
GAISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMI
SSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILA
ETGLSFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLR
DALDPASRSLRRGVR"
gene complement(1436140..1437117)
/gene="oppB"
/locus_tag="Rv1283c"
CDS complement(1436140..1437117)
/codon_start=1
/transl_table=11
/gene="oppB"
/locus_tag="Rv1283c"
/product="Probable oligopeptide-transport integral
membrane protein ABC transporter OppB"
/note="Rv1283c, (MTCY373.02c), len: 325 aa. Probable
oppB,oligopeptide-transport integral membrane protein ABC
transporter (see citation below), similar to other
integral membrane proteins e.g. DPPB_ECOLI|P37316
dipeptide transport system permease protein from
Escherichia coli (339 aa), FASTA scores: opt: 402, E():
3.4e-20, (31.0% identity in 345 aa overlap); etc. Also
similar to Rv3665c|DppB probable peptide-transport
integral membrane protein from Mycobacterium tuberculosis.
Contains PS00402 Binding-protein-dependent transport
systems inner membrane comp signature."
/db_xref="EnsemblGenomes-Gn:Rv1283c"
/db_xref="EnsemblGenomes-Tr:CCP44039"
/db_xref="GOA:P9WFZ7"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WFZ7"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP44039.1"
/translation="MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRP
PQAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLL
VVGSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNW
AVGIQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDV
LGQDFIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHG
MGEWMVRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS"
gene 1437324..1437815
/gene="canA"
/locus_tag="Rv1284"
CDS 1437324..1437815
/codon_start=1
/transl_table=11
/gene="canA"
/locus_tag="Rv1284"
/product="Beta-carbonic anhydrase"
/note="Rv1284, (MTCY373.03), len: 163 aa.
CanA,Beta-carbonic anhydrase, proven biochemically (See
Suarez Covarrubias et al. 2005) similar to others e.g.
AL109663|SC4A10.26 hypothetical protein from Streptomyces
coelicolor (167 aa), FASTA scores: opt: 567, E():
1.5e-32,(53.4% identity in 163 aa overla); shows some
similarity to hypothetical protein from Methanobacterium
thermoautotrophicum. Weak similarity to carbonic
anhydrases e.g. U51624|MTU516242|P17582
Methanothermobacter thermautotrophicus (171 aa), FASTA
score: opt: 305, E(): 1.2e-14, (35.2% identity in 165 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1284"
/db_xref="EnsemblGenomes-Tr:CCP44040"
/db_xref="GOA:P9WPJ7"
/db_xref="InterPro:IPR001765"
/db_xref="InterPro:IPR036874"
/db_xref="PDB:1YLK"
/db_xref="PDB:4YF4"
/db_xref="PDB:4YF5"
/db_xref="PDB:4YF6"
/db_xref="UniProtKB/Swiss-Prot:P9WPJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44040.1"
/translation="MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYR
MLGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFK
RAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNE
VTP"
gene 1437909..1438907
/gene="cysD"
/locus_tag="Rv1285"
CDS 1437909..1438907
/codon_start=1
/transl_table=11
/gene="cysD"
/locus_tag="Rv1285"
/product="Probable sulfate adenylyltransferase subunit 2
CysD"
/note="Rv1285, (MTCY373.04), len: 332 aa. Probable
cysD,sulfate adenylyltransferase subunit 2 (see Wooff et
al.,2002), homology suggests start site at aa 24 or 28,
similar to e.g. CYSD_ECOLI|P21156 sulfate adenylate
transferase subunit 2 from Escherichia coli (302 aa),
FASTA score: opt: 973, E():0, (52.5% identity in 303 aa
overlap). Also similar to Mycobacterium tuberculosis
Rv2392,3'-phosphoadenylylsulfate reductase. Belongs to the
PAPS reductase family. CYSD subfamily. Thought to be
differentially expressed within host cells (see Triccas et
al., 1999)."
/db_xref="EnsemblGenomes-Gn:Rv1285"
/db_xref="EnsemblGenomes-Tr:CCP44041"
/db_xref="GOA:P9WIK1"
/db_xref="InterPro:IPR002500"
/db_xref="InterPro:IPR011784"
/db_xref="InterPro:IPR014729"
/db_xref="UniProtKB/Swiss-Prot:P9WIK1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44041.1"
/translation="MAITINMVNPTGFIRYEDVEQEAMTSDVTVGPAPGQYQLSHLRL
LEAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNF
DEVIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDA
AFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSN
WTEFDIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFR
TVGDVTCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF"
gene 1438907..1440751
/gene="cysN"
/locus_tag="Rv1286"
CDS 1438907..1440751
/codon_start=1
/transl_table=11
/gene="cysN"
/locus_tag="Rv1286"
/product="Probable bifunctional enzyme CysN/CysC: sulfate
adenyltransferase (subunit 1) + adenylylsulfate kinase"
/note="Rv1286, (MTCY373.05), len: 614 aa. Probable
cysN/cysC bifunctional enzyme, sulfate adenylyltransferase
subunit 1 and Adenylylsulfate kinase (see Wooff et
al.,2002), similar to CYSN_ECOLI|P23845 sulfate adenylate
transferase subunit 1 from Escherichia coli (475 aa),
FASTA scores: opt: 1291, E():0, (50.2% identity in 428 aa
overlap). Contains 2 x PS00017 ATP/GTP-binding site motif
A, PS00301 GTP-binding elongation factors signature."
/db_xref="EnsemblGenomes-Gn:Rv1286"
/db_xref="EnsemblGenomes-Tr:CCP44042"
/db_xref="GOA:P9WNM5"
/db_xref="InterPro:IPR000795"
/db_xref="InterPro:IPR002891"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR009001"
/db_xref="InterPro:IPR011779"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031157"
/db_xref="InterPro:IPR041757"
/db_xref="PDB:4BZQ"
/db_xref="PDB:4BZX"
/db_xref="PDB:4RFV"
/db_xref="UniProtKB/Swiss-Prot:P9WNM5"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00301"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44042.1"
/translation="MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVEQTSK
DRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTG
ASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVLAVNKMDLLGWDQEKFDAIRD
EFHAFAARLDVQDVTSIPISALHGDNVVTKSDQTPWYEGPSLLSHLEDVYIAGDRNMV
DVRFPVQYVIRPHTLEHQDHRSYAGTVASGVMRSGDEVVVLPIGKTTRITAIDGPNGP
VAEAFPPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLEPGRDY
VVKHTTRTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLRTQVPLLLDEYTRN
ASTGSFILIDPDTNGTVAAGMVLRDVSARTPSPNTVRHRSLVTAQDRPPRGKTVWFTG
LSGSGKSSVAMLVERKLLEKGISAYVLDGDNLRHGLNADLGFSMADRAENLRRLSHVA
TLLADCGHLVLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPKGLYA
KARAGEITHFTGIDSPYQRPKNPDLRLTPDRSIDEQAQEVIDLLESSS"
gene 1440805..1441290
/locus_tag="Rv1287"
CDS 1440805..1441290
/codon_start=1
/transl_table=11
/locus_tag="Rv1287"
/product="Conserved hypothetical protein"
/note="Rv1287, (MTCY373.06), len: 161 aa. Conserved
hypothetical protein, similar to VjeB family of proteins
e.g. FASTA score: P44675|Y379_HAEIN hypothetical protein
HI0379 (150 aa), FASTA scores: opt: 213, E():
2.5e-08,(30.0% identity in 130 aa overlap) and
YJEB_ECOLI|P21498 hypothetical 15.6 kDa protein in
pura-vacb (141 aa), opt: 167, E(): 9.5e-06, (25.0%
identity in 136 aa overlap). Belongs to the UPF0074 (RFF2)
family."
/db_xref="EnsemblGenomes-Gn:Rv1287"
/db_xref="EnsemblGenomes-Tr:CCP44043"
/db_xref="GOA:P9WME3"
/db_xref="InterPro:IPR000944"
/db_xref="InterPro:IPR030489"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WME3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44043.1"
/translation="MRMSAKAEYAVRAMVQLATAASGTVVKTDDLAAAQGIPPQFLVD
ILTNLRTDRLVRSHRGREGGYELARPGTEISIADVLRCIDGPLASVRDIGLGDLPYSG
PTTALTDVWRALRASMRSVLEETTLADVAGGALPEHVAQLADDYRAQESTRHGASRHG
D"
gene 1441348..1442718
/locus_tag="Rv1288"
CDS 1441348..1442718
/codon_start=1
/transl_table=11
/locus_tag="Rv1288"
/product="Conserved protein"
/note="Rv1288, (MTCY373.07), len: 456 aa. Conserved
protein, some similarity to A85B_MYCTU|P31952 antigen 85-b
precursor (85b) (325 aa), FASTA scores: opt: 199, E():
2.7e-06, (24.7% identity in 279 aa overlap). Also similar
to Q01377|CSP1_CORGL PS1 protein precursor (related to
antigen 85 complex) from Corynebacterium glutamicum (657
aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity
in 352 aa overlap). Seems to contain 3 LYSM repeats"
/db_xref="EnsemblGenomes-Gn:Rv1288"
/db_xref="EnsemblGenomes-Tr:CCP44044"
/db_xref="GOA:P9WM39"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR018392"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR036779"
/db_xref="UniProtKB/Swiss-Prot:P9WM39"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44044.1"
/translation="MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNV
GQRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMP
DFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGF
GLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQ
DFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIE
ANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWA
NLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDS
VNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGA
AAERAD"
gene 1442767..1443399
/locus_tag="Rv1289"
CDS 1442767..1443399
/codon_start=1
/transl_table=11
/locus_tag="Rv1289"
/product="Unknown protein"
/note="Rv1289, (MTCY373.08), len: 210 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1289"
/db_xref="EnsemblGenomes-Tr:CCP44045"
/db_xref="GOA:P9WM37"
/db_xref="UniProtKB/Swiss-Prot:P9WM37"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44045.1"
/translation="MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLG
VGTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWL
HGHADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPP
DYQLSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG"
gene complement(1443482..1445047)
/locus_tag="Rv1290c"
CDS complement(1443482..1445047)
/codon_start=1
/transl_table=11
/locus_tag="Rv1290c"
/product="Conserved protein"
/note="Rv1290c, (MTCY373.09c), len: 521 aa. Conserved
protein (see citation below), similar to AL031013|SC8A6.09
hypothetical protein from Streptomyces coelicolor (443
aa),FASTA scores: opt: 371, E(): 9.5e-17, (28.3% identity
in 446 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1290c"
/db_xref="EnsemblGenomes-Tr:CCP44046"
/db_xref="GOA:P9WM35"
/db_xref="InterPro:IPR018723"
/db_xref="UniProtKB/Swiss-Prot:P9WM35"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44046.1"
/translation="MLQRSLGVNGRKLAMSARSAKRERKNASTAASKCYVVPPSARGW
VHAYSVTATSMLNRRKAILDYLQGAVWVLPTFGVAIGLGSGAVLSMIPVKSGTLIDKL
MFQGTPGDARGVLIVVSATMITTIGIVFSLTVLSLQIASSQFSVRLLRTFLRDVPNQV
VLAIFACTFAYSTGGLHTVGEHRDGGAFIPKVAVTGSLALAFVSIAALIYFLHHLMHS
IQIDTIMDKVRLRTLGLVDQLYPESDTADRQVETPPSPPADAVPLLAPHSGYLQTVDV
DDIAELAAASRYTALLVTFVGDYVTAGGLLGWCWRRGTAPGAPGSDFPQRCLRHVHIG
FERTLQQDIRFGLRQMVDIALRALSPALNDPYTAIQVVHHLSAVESVLASRALPDDVR
RDRAGELLFWLPYPSFATYLHVGCAQIRRYGSREPLVLTALLQLLSAVAQNCVDPSRR
VAVQTQIALVVRAAQREFADESDRAMVLGAAARATEVVERPGTLAPPPSTFGQVAAAQ
AAASTIRSADRDG"
gene 1445058..1445372
/locus_tag="Rv1290A"
CDS 1445058..1445372
/codon_start=1
/transl_table=11
/locus_tag="Rv1290A"
/product="Hypothetical protein"
/note="Rv1290A, len: 104 aa. Hypothetical unknown
protein,equivalent to AAK45590 from Mycobacterium
tuberculosis strain CDC1551 (122 aa) but shorter 18 aa."
/db_xref="EnsemblGenomes-Gn:Rv1290A"
/db_xref="EnsemblGenomes-Tr:CCP44047"
/db_xref="UniProtKB/TrEMBL:Q79FQ6"
/protein_id="CCP44047.1"
/translation="MLALHGLSEGVSGSGGSGGRWGAGEVLEGARIGVIADGVSCFPT
KADCRRIRGVPVFDGYTRMVARLMGSLAVLRSVSIPKGYRDFGFGSLRAVAPKNCPDV
SG"
gene complement(1445499..1445834)
/locus_tag="Rv1291c"
CDS complement(1445499..1445834)
/codon_start=1
/transl_table=11
/locus_tag="Rv1291c"
/product="Conserved hypothetical secreted protein"
/note="Rv1291c, (MTCY373.10c), len: 111 aa. Conserved
hypothetical secreted protein, similar to others in
Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU
hypothetical 11.6 kDa protein (113 aa), FASTA score: opt:
246, E(): 1.7e-09, (40.0% identity in 110 aa overlap);
Rv1804c, Rv1810, Rv0622, etc."
/db_xref="EnsemblGenomes-Gn:Rv1291c"
/db_xref="EnsemblGenomes-Tr:CCP44048"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/Swiss-Prot:P9WM33"
/protein_id="CCP44048.1"
/translation="MFTRRFAASMVGTTLTAATLGLAALGFAGTASASSTDEAFLAQL
QADGITPPSAARAIKDAHAVCDALDEGHSAKAVIKAVAKATGLSAKGAKTFAVDAASA
YCPQYVTSS"
gene complement(1446193..1446265)
/gene="argV"
tRNA complement(1446193..1446265)
/gene="argV"
/product="tRNA-Arg"
/anticodon=(pos:complement(1446230..1446232),aa:Arg,
seq:ccg)
/note="codon recognized: CGG; argV, tRNA-Arg, anticodon
ccg, length = 73"
gene 1446379..1448031
/gene="argS"
/locus_tag="Rv1292"
CDS 1446379..1448031
/codon_start=1
/transl_table=11
/gene="argS"
/locus_tag="Rv1292"
/product="Probable arginyl-tRNA synthetase ArgS (ARGRS)
(arginine--tRNA ligase)"
/note="Rv1292, (MTCY373.12), len: 550 aa. Probable
argS,Arginyl-tRNA synthetase, highly similar to
SYR_MYCLE|P45840 Mycobacterium leprae (550 aa), FASTA
scores: opt: 3115,E(): 0, (84.9% identity in 550 aa
overlap). Contains PS00178 Aminoacyl-transfer RNA
synthetases class-I signature. Belongs to class-I
aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv1292"
/db_xref="EnsemblGenomes-Tr:CCP44049"
/db_xref="GOA:P9WFW5"
/db_xref="InterPro:IPR001278"
/db_xref="InterPro:IPR001412"
/db_xref="InterPro:IPR005148"
/db_xref="InterPro:IPR008909"
/db_xref="InterPro:IPR009080"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR035684"
/db_xref="InterPro:IPR036695"
/db_xref="UniProtKB/Swiss-Prot:P9WFW5"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44049.1"
/translation="MTPADLAELLKATAAAVLAERGLDASALPQMVTVERPRIPEHGD
YASNLAMQLAKKVGTNPRELAGWLAEALTKVDGIASAEVAGPGFINMRLETAAQAKVV
TSVIDAGHSYGHSLLLAGRKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLTTQGAD
VVREYYFNDHGAQIDRFANSLIAAAKGEPTPQDGYAGSYITNIAEQVLQKAPDALSLP
DAELRETFRAIGVDLMFDHIKQSLHEFGTDFDVYTHEDSMHTGGRVENAIARLRETGN
IYEKDGATWLRTSAFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGAD
HHGYIARLKAAAAAFGDDPATVEVLIGQMVNLVRDGQPVRMSKRAGTVLTLDDLVEAI
GVDAARYSLIRSSVDTAIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELALIP
DTNHLELLNHDKEGTLLRTLGEFPRVLETAASLREPHRVCRYLEDLAGDYHRFYDSCR
VLPQGDEQPTDLHTARLALCQATRQVIANGLAIIGVTAPERM"
gene 1448028..1449371
/gene="lysA"
/locus_tag="Rv1293"
CDS 1448028..1449371
/codon_start=1
/transl_table=11
/gene="lysA"
/locus_tag="Rv1293"
/product="Diaminopimelate decarboxylase LysA (DAP
decarboxylase)"
/note="Rv1293, (MTCY373.13), len: 447 aa.
lysA,diaminopimelate decarboxylase (see citation below),
almost identical to DCDA_MYCTU|P31848. Contains PS00878
Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment
site, PS00879 Orn/DAP/Arg decarboxylases family 2
signature 2. Belongs to family 2 of ornithine, DAP, and
arginine decarboxylases."
/db_xref="EnsemblGenomes-Gn:Rv1293"
/db_xref="EnsemblGenomes-Tr:CCP44050"
/db_xref="GOA:P9WIU7"
/db_xref="InterPro:IPR000183"
/db_xref="InterPro:IPR002986"
/db_xref="InterPro:IPR009006"
/db_xref="InterPro:IPR022643"
/db_xref="InterPro:IPR022644"
/db_xref="InterPro:IPR022653"
/db_xref="InterPro:IPR022657"
/db_xref="InterPro:IPR029066"
/db_xref="PDB:1HKV"
/db_xref="PDB:1HKW"
/db_xref="PDB:2O0T"
/db_xref="UniProtKB/Swiss-Prot:P9WIU7"
/inference="protein motif:PROSITE:PS00878"
/inference="protein motif:PROSITE:PS00879"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44050.1"
/translation="MNELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFV
IDEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVAL
HASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLV
RLTVGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQI
FDVDGFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELA
AKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVS
VDGGMSDNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIR
PGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR"
gene 1449375..1450700
/gene="thrA"
/locus_tag="Rv1294"
CDS 1449375..1450700
/codon_start=1
/transl_table=11
/gene="thrA"
/locus_tag="Rv1294"
/product="Probable homoserine dehydrogenase ThrA"
/note="Rv1294, (MTCY373.14), len: 441 aa. Probable thrA
(hom), homoserine dehydrogenase, highly similar to
DHOM_MYCLE|P46806 from Mycobacterium leprae (441 aa),
FASTA scores: opt: 2437, E():0, (89.5% identity in 438 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A;
PS01042 Homoserine dehydrogenase signature. Belongs to the
homoserine dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv1294"
/db_xref="EnsemblGenomes-Tr:CCP44051"
/db_xref="GOA:P9WPX1"
/db_xref="InterPro:IPR001342"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR005106"
/db_xref="InterPro:IPR016204"
/db_xref="InterPro:IPR019811"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WPX1"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS01042"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44051.1"
/translation="MPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLR
GIGVRRVTTDRGVPIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSV
VTANKALLATSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIV
NGTTNYILSAMDSTGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHT
RVTADDVYREGITKVTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVP
LSHPLAAVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRG
PRESKYAQLPVAPMGFIETRYYVSMNVADKPGVLSAVAAEFAKREVSIAEVRQEGVVD
EGGRRVGARIVVVTHLATDAALSETVDALDDLDVVQGVSSVIRLEGTGL"
gene 1450697..1451779
/gene="thrC"
/locus_tag="Rv1295"
CDS 1450697..1451779
/codon_start=1
/transl_table=11
/gene="thrC"
/locus_tag="Rv1295"
/product="Threonine synthase ThrC (ts)"
/note="Rv1295, (MTCY373.15), len: 360 aa. thrC, threonine
synthase (see Parish et al., 1999), highly similar to
THRC_MYCLE|P45837 Mycobacterium leprae (360 aa), FASTA
scores: opt: 2202, E(): 0, (93.9% identity in 359 aa
overlap). Contains PS00165 Serine/threonine dehydratases
pyridoxal-phosphate attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1295"
/db_xref="EnsemblGenomes-Tr:CCP44052"
/db_xref="GOA:P9WG59"
/db_xref="InterPro:IPR000634"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR004450"
/db_xref="InterPro:IPR026260"
/db_xref="InterPro:IPR036052"
/db_xref="PDB:2D1F"
/db_xref="UniProtKB/Swiss-Prot:P9WG59"
/inference="protein motif:PROSITE:PS00165"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44052.1"
/translation="MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAA
TNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAA
YAARAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTIS
LVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLID
KLPRMLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAAS
DEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPD
TALKDMPSVSPVPVDPVAVVEKLGLA"
gene 1451997..1452947
/gene="thrB"
/locus_tag="Rv1296"
CDS 1451997..1452947
/codon_start=1
/transl_table=11
/gene="thrB"
/locus_tag="Rv1296"
/product="Probable homoserine kinase ThrB"
/note="Rv1296, (MTCY373.16), len: 316 aa. Probable
thrB,homoserine kinase (see citation below), highly
similar to KHSE_MYCLE|P45836 from Mycobacterium leprae
(314 aa), FASTA scores, opt: 1657, E(): 0, (82.0% identity
in 311 aa overlap). Contains PS00639 Eukaryotic thiol
(cysteine) proteases histidine active site, and PS00627
GHMP kinases putative ATP-binding domain."
/db_xref="EnsemblGenomes-Gn:Rv1296"
/db_xref="EnsemblGenomes-Tr:CCP44053"
/db_xref="GOA:P9WKE7"
/db_xref="InterPro:IPR000870"
/db_xref="InterPro:IPR006203"
/db_xref="InterPro:IPR006204"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR036554"
/db_xref="UniProtKB/Swiss-Prot:P9WKE7"
/inference="protein motif:PROSITE:PS00639"
/inference="protein motif:PROSITE:PS00627"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44053.1"
/translation="MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYDEIIVE
TTDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLAVRCRNAIPHSRGL
GSSAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASEFEGHPDNAAAAVLGGAVVSWT
DHSGDRPNYSAVSLRLHPDIRLFTAIPEQRSSTAETRVLLPAQVSHDDARFNVSRAAL
LVVALTERPDLLMAATEDLLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIAL
STDSELPTDAVEFGAAKGFAVTELTVGEAVRWSPTVRVPG"
gene 1453204..1455012
/gene="rho"
/locus_tag="Rv1297"
CDS 1453204..1455012
/codon_start=1
/transl_table=11
/gene="rho"
/locus_tag="Rv1297"
/product="Probable transcription termination factor Rho
homolog"
/note="Rv1297, (MTCY373.17), len: 602 aa. Probable
rho,transcription termination factor homolog, highly
similar to many e.g. RHO_MYCLE|P45835 Mycobacterium leprae
(610 aa),FASTA scores: (81.5% identity in 612 aa overlap).
Contains 1 RNA recognition motif (RRM). Nucleotide
position 1453608 in the genome sequence has been
corrected, T:C resulting in G135G."
/db_xref="EnsemblGenomes-Gn:Rv1297"
/db_xref="EnsemblGenomes-Tr:CCP44054"
/db_xref="GOA:P9WHF3"
/db_xref="InterPro:IPR000194"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004665"
/db_xref="InterPro:IPR011112"
/db_xref="InterPro:IPR011113"
/db_xref="InterPro:IPR011129"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036269"
/db_xref="InterPro:IPR041703"
/db_xref="UniProtKB/Swiss-Prot:P9WHF3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44054.1"
/translation="MTDTDLITAGESTDGKPSDAAATDPPDLNADEPAGSLATMVLPE
LRALANRAGVKGTSGMRKNELIAAIEEIRRQANGAPAVDRSAQEHDKGDRPPSSEAPA
TQGEQTPTEQIDSQSQQVRPERRSATREAGPSGSGERAGTAADDTDNRQGGQQDAKTE
ERGTDAGGDQGGDQQASGGQQARGDEDGEARQGRRGRRFRDRRRRGERSGDGAEAELR
EDDVVQPVAGILDVLDNYAFVRTSGYLPGPHDVYVSMNMVRKNGMRRGDAVTGAVRVP
KEGEQPNQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETSTERLTT
RVIDLIMPIGKGQRALIVSPPKAGKTTILQDIANAITRNNPECHLMVVLVDERPEEVT
DMQRSVKGEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYN
NASPASGRILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDTVIFE
EFKGTGNAELKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFAIVHKLRRVLSGLD
SHQAIDLLMSQLRKTKNNYEFLVQVSKTTPGSMDSD"
gene 1455163..1455405
/gene="rpmE"
/locus_tag="Rv1298"
CDS 1455163..1455405
/codon_start=1
/transl_table=11
/gene="rpmE"
/locus_tag="Rv1298"
/product="50S ribosomal protein L31 RpmE"
/note="Rv1298, (MTCY373.18), len: 80 aa. rpmE, 50s
ribosomal protein L31, highly similar to many e.g.
RL31_MYCLE|P45834 50s ribosomal protein L31 from
Mycobacterium leprae (84 aa), FASTA scores: opt: 490, E():
5.5e-28, (89.6% identity in 77 aa overlap). Contains
PS01143 Ribosomal protein L31 signature. Belongs to the
L31P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv1298"
/db_xref="EnsemblGenomes-Tr:CCP44055"
/db_xref="GOA:P9WHA1"
/db_xref="InterPro:IPR002150"
/db_xref="InterPro:IPR027491"
/db_xref="InterPro:IPR034704"
/db_xref="InterPro:IPR042105"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHA1"
/inference="protein motif:PROSITE:PS01143"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44055.1"
/translation="MKSDIHPAYEETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPF
YTGKQKILDSGGRVARFEKRYGKRKVGADKAVSTGK"
gene 1455495..1456568
/gene="prfA"
/locus_tag="Rv1299"
CDS 1455495..1456568
/codon_start=1
/transl_table=11
/gene="prfA"
/locus_tag="Rv1299"
/product="Probable peptide chain release factor 1 PrfA
(RF-1)"
/note="Rv1299, (MTCY373.19), len: 357 aa. Probable
prfA,peptide chain release factor 1 (rf-1), highly similar
to many e.g. RF1_MYCLE|P45833 peptide chain release factor
1 (rf-1) from Mycobacterium leprae (357 aa), FASTA scores:
opt: 2047, E(): 0, (89.3% identity in 356 aa overlap);
also similar to Mycobacterium tuberculosis Rv3105c, prfB
peptide chain release factor 2. Contains PS00745
Prokaryotic-type class I peptide chain release factors
signature. Belongs to the prokaryotic and mitochondrial
release factors family."
/db_xref="EnsemblGenomes-Gn:Rv1299"
/db_xref="EnsemblGenomes-Tr:CCP44056"
/db_xref="GOA:P9WHG3"
/db_xref="InterPro:IPR000352"
/db_xref="InterPro:IPR004373"
/db_xref="InterPro:IPR005139"
/db_xref="UniProtKB/Swiss-Prot:P9WHG3"
/inference="protein motif:PROSITE:PS00745"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44056.1"
/translation="MTQPVQTIDVLLAEHAELELALADPALHSNPAEARRVGRRFARL
APIVATHRKLTSARDDLETARELVASDESFAAEVAALEARVGELDAQLTDMLAPRDPH
DADDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWAVTVLDETTSDLGGYKDATL
AIASKADTPDGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVGQVQI
DESDLRIDVFRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKTRALQVLA
ARLQAMAEEQALADASADRASQIRTVDRSERIRTYNFPENRITDHRIGYKSHNLDQVL
DGDLDALFDALSAADKQSRLRQS"
gene 1456565..1457542
/gene="hemK"
/locus_tag="Rv1300"
CDS 1456565..1457542
/codon_start=1
/transl_table=11
/gene="hemK"
/locus_tag="Rv1300"
/product="Probable HemK protein homolog HemK"
/note="Rv1300, (MTCY373.20), len: 325 aa. Probable hemK
protein homolog, homology suggests translation may start
at aa 22, highly similar to many e.g. HEMK_MYCLE|P45832
Mycobacterium leprae (288 aa), FASTA scores: opt: 936,
E(): 0, (76.7% identity in 189 aa overlap). Belongs to the
HemK family of modification methylases."
/db_xref="EnsemblGenomes-Gn:Rv1300"
/db_xref="EnsemblGenomes-Tr:CCP44057"
/db_xref="GOA:P9WHV3"
/db_xref="InterPro:IPR002052"
/db_xref="InterPro:IPR004556"
/db_xref="InterPro:IPR019874"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR040758"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/Swiss-Prot:P9WHV3"
/protein_id="CCP44057.1"
/translation="MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSAR
CDAEQLAAHLAGTDRGRLPLFEPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVV
LHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALAQHRANLGLKAR
IIGIDDSDCALDYARRNAAGTPVELVRADVTTPRLLPELDGQVDLMVSNPPYIPDAAV
LEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVS
STKLFVDVQARKDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR"
repeat_region 1456585..1456627
/gene="hemK"
/locus_tag="Rv1300"
/note="43 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
repeat_region 1457453..1457504
/gene="hemK"
/locus_tag="Rv1300"
/note="52 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
repeat_region 1457505..1457557
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 1457558..1458211
/locus_tag="Rv1301"
CDS 1457558..1458211
/codon_start=1
/transl_table=11
/locus_tag="Rv1301"
/product="Conserved protein"
/note="Rv1301, (MTCY373.21), len: 217 aa. Conserved
protein, highly similar to YRFE_MYCLE|P45831 hypothetical
22.7 kDa protein in rfe-hemk intergenic region, (220
aa),FASTA scores: opt: 1168, E(): 0, (82.8% identity in
215 aa overlap). Contains PS01147 Hypothetical
SUA5/yciO/yrdC family signature. Belongs to the
SUA5/YRDC/YCIO/YWLC family."
/db_xref="EnsemblGenomes-Gn:Rv1301"
/db_xref="EnsemblGenomes-Tr:CCP44058"
/db_xref="GOA:P9WGC9"
/db_xref="InterPro:IPR006070"
/db_xref="InterPro:IPR017945"
/db_xref="UniProtKB/Swiss-Prot:P9WGC9"
/inference="protein motif:PROSITE:PS01147"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44058.1"
/translation="MTETFDCADPEQRSRGIVSAVGAIKAGQLVVMPTDTVYGIGADA
FDSSAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYSMPDGARELIRAFWPGALSLVV
VQAPSLQWDLGDAHGTVMLRMPLHPVAIELLREVGPMAVSSANISGHPPPVDAEQARS
QLGDHVAVYLDAGPSEQQAGSTIVDLTGATPRVLRPGPVSTERIAEVLGVDAASLFG"
gene 1458295..1459509
/gene="rfe"
/gene_synonym="wecA"
/locus_tag="Rv1302"
CDS 1458295..1459509
/codon_start=1
/transl_table=11
/gene="rfe"
/gene_synonym="wecA"
/locus_tag="Rv1302"
/product="Probable undecapaprenyl-phosphate
alpha-N-acetylglucosaminyltransferase Rfe (UDP-GlcNAc
transferase)"
/note="Rv1302, (MTCY373.22), len: 404 aa. Probable rfe
(alternate gene name: wecA), undecaprenyl-phosphate
alpha-N-acetylglucosaminyltransferase (see citation
below),equivalent to RFE_MYCLE|P45830 Mycobacterium leprae
(398 aa), FASTA scores, opt: 2285, E(): 0, (89.2% identity
in 398 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1302"
/db_xref="EnsemblGenomes-Tr:CCP44059"
/db_xref="GOA:P9WMW5"
/db_xref="InterPro:IPR000715"
/db_xref="UniProtKB/Swiss-Prot:P9WMW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44059.1"
/translation="MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIIT
YFATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRG
FVYSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIP
VGGVGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLL
RDHGGDVLYYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAA
GPISQNAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHH
RLLQIGHSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLL
RRGDDYYDPDLD"
gene 1459766..1460251
/locus_tag="Rv1303"
CDS 1459766..1460251
/codon_start=1
/transl_table=11
/locus_tag="Rv1303"
/product="Conserved hypothetical transmembrane protein"
/note="Rv1303, (MTCY373.23), len: 161 aa. Conserved
hypothetical transmembrane protein, highly similar to
P53431|Y02N_MYCLE hypothetical Mycobacterium leprae
protein (153 aa), FASTA score: opt: 636, E():0, (69.8%
identity in 149 aa overlap). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004)."
/db_xref="EnsemblGenomes-Gn:Rv1303"
/db_xref="EnsemblGenomes-Tr:CCP44060"
/db_xref="GOA:P9WM31"
/db_xref="InterPro:IPR005598"
/db_xref="UniProtKB/Swiss-Prot:P9WM31"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44060.1"
/translation="MTTPAQDAPLVFPSVAFRPVRLFFINVGLAAVAMLVAGVFGHLT
VGMFLGLGLLLGLLNALLVRRSAESITAKEHPLKRSMALNSASRLAIITILGLIIAYI
FRPAGLGVVFGLAFFQVLLVATTALPVLKKLRTATEEPVATYSSNGQTGGSEGRSASD
D"
gene 1460244..1460996
/gene="atpB"
/locus_tag="Rv1304"
CDS 1460244..1460996
/codon_start=1
/transl_table=11
/gene="atpB"
/locus_tag="Rv1304"
/product="Probable ATP synthase a chain AtpB (protein 6)"
/note="Rv1304, (MTCY373.24), len: 250 aa. Probable
atpB,ATP synthase a chain, highly similar to
ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa), FASTA
scores: opt: 1382,E(): 0, (84.0% identity in 250 aa
overlap). Contains PS00449 ATP synthase a subunit
signature. subunit: F-type ATPases have 2 components,
cf(1) - the catalytic core - and cf(0) - the membrane
proton channel. cf(1) has five subunits: alpha(3),
beta(3), gamma(1), delta(1),epsilon(1). cf(0) has three
main subunits: A, B and C. Belongs to the ATPase a chain
family."
/db_xref="EnsemblGenomes-Gn:Rv1304"
/db_xref="EnsemblGenomes-Tr:CCP44061"
/db_xref="GOA:P9WPV7"
/db_xref="InterPro:IPR000568"
/db_xref="InterPro:IPR023011"
/db_xref="InterPro:IPR035908"
/db_xref="UniProtKB/Swiss-Prot:P9WPV7"
/inference="protein motif:PROSITE:PS00449"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44061.1"
/translation="MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALA
FYLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISN
WLAVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKL
LKGHVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKA
FDLFVGAIQAFIFALLTILYFSQAMELEEEHH"
gene 1461045..1461290
/gene="atpE"
/locus_tag="Rv1305"
CDS 1461045..1461290
/codon_start=1
/transl_table=11
/gene="atpE"
/locus_tag="Rv1305"
/product="Probable ATP synthase C chain AtpE
(lipid-binding protein) (dicyclohexylcarbodiimide-binding
protein)"
/note="Rv1305, (MTCY373.25), len: 81 aa. Probable atpE,
ATP synthase C chain, highly similar to P45828|ATPL_MYCLE
Mycobacterium leprae (92.6% identity in 81 aa overlap).
Contains PS00605 ATP synthase C subunit signature.
subunit: F-type ATPases have 2 components, cf(1) - the
catalytic core - and cf(0) - the membrane proton channel.
cf(1) has five subunits: alpha(3), beta(3), gamma(1),
delta(1),epsilon(1). cf(0) has three main subunits: A, B
and C. Belongs to the ATPase C chain family."
/db_xref="EnsemblGenomes-Gn:Rv1305"
/db_xref="EnsemblGenomes-Tr:CCP44062"
/db_xref="GOA:P9WPS1"
/db_xref="InterPro:IPR000454"
/db_xref="InterPro:IPR002379"
/db_xref="InterPro:IPR005953"
/db_xref="InterPro:IPR020537"
/db_xref="InterPro:IPR035921"
/db_xref="InterPro:IPR038662"
/db_xref="UniProtKB/Swiss-Prot:P9WPS1"
/inference="protein motif:PROSITE:PS00605"
/protein_id="CCP44062.1"
/translation="MDPTIAAGALIGGGLIMAGGAIGAGIGDGVAGNALISGVARQPE
AQGRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK"
gene 1461321..1461836
/gene="atpF"
/locus_tag="Rv1306"
CDS 1461321..1461836
/codon_start=1
/transl_table=11
/gene="atpF"
/locus_tag="Rv1306"
/product="Probable ATP synthase B chain AtpF"
/note="Rv1306, (MTCY373.26), len: 171 aa. Probable
atpF,ATP synthase B chain, highly similar to ATPF_MYCLE
P45827 (170 aa), FASTA scores, opt: 802, E(): 0, (79.5%
identity in 171 aa overlap). subunit: F-type ATPases have
2 components, cf(1) - the catalytic core - and cf(0) - the
membrane proton channel. cf(1) has five subunits:
alpha(3),beta(3), gamma(1), delta(1), epsilon(1). cf(0)
has three main subunits: A, B and C. Belongs to the ATPase
B chain family."
/db_xref="EnsemblGenomes-Gn:Rv1306"
/db_xref="EnsemblGenomes-Tr:CCP44063"
/db_xref="GOA:P9WPV5"
/db_xref="InterPro:IPR002146"
/db_xref="InterPro:IPR028987"
/db_xref="UniProtKB/Swiss-Prot:P9WPV5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44063.1"
/translation="MGEVSAIVLAASQAAEEGGESSNFLIPNGTFFVVLAIFLVVLAV
IGTFVVPPILKVLRERDAMVAKTLADNKKSDEQFAAAQADYDEAMTEARVQASSLRDN
ARADGRKVIEDARVRAEQQVASTLQTAHEQLKRERDAVELDLRAHVGTMSATLASRIL
GVDLTASAATR"
gene 1461843..1463183
/gene="atpH"
/locus_tag="Rv1307"
CDS 1461843..1463183
/codon_start=1
/transl_table=11
/gene="atpH"
/locus_tag="Rv1307"
/product="Probable ATP synthase delta chain AtpH"
/note="Rv1307, (MTCY373.27), len: 446 aa. Probable
atpH,ATP synthase delta chain. This protein is much longer
than that of other bacterial delta chains, the C-terminal
region is homologous to delta chains while the N-terminal
region is similar to B/B' subunits e.g. ATPD_STRLI|P50008
ATP synthase delta chain from Streptomyces lividans (273
aa),FASTA scores: opt: 505, E(): 5.4e-23, (35.0% identity
in 277 aa overlap); and ATPF_HAEIN|P43720 ATP synthase B
chain from Haemophilus influenzae (156 aa), FASTA scores:
opt: 216, E(): 1.2e-06, (26.1% identity in 153 aa
overlap). subunit: F-type ATPases have 2 components, cf(1)
- the catalytic core - and cf(0) - the membrane proton
channel. cf(1) has five subunits: alpha(3), beta(3),
gamma(1),delta(1), epsilon(1). cf(0) has three main
subunits: A, B and C. Belongs to the ATPase delta chain
family."
/db_xref="EnsemblGenomes-Gn:Rv1307"
/db_xref="EnsemblGenomes-Tr:CCP44064"
/db_xref="GOA:P9WPV3"
/db_xref="InterPro:IPR000711"
/db_xref="InterPro:IPR002146"
/db_xref="InterPro:IPR005864"
/db_xref="InterPro:IPR028987"
/db_xref="UniProtKB/Swiss-Prot:P9WPV3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44064.1"
/translation="MSTFIGQLFGFAVIVYLVWRFIVPLVGRLMSARQDTVRQQLADA
AAAADRLAEASQAHTKALEDAKSEAHRVVEEARTDAERIAEQLEAQADVEAERIKMQG
ARQVDLIRAQLTRQLRLELGHESVRQARELVRNHVADQAQQSATVDRFLDQLDAMAPA
TADVDYPLLAKMRSASRRALTSLVDWFGTMAQDLDHQGLTTLAGELVSVARLLDREAV
VTRYLTVPAEDATPRIRLIERLVSGKVGAPTLEVLRTAVSKRWSANSDLIDAIEHVSR
QALLELAERAGQVDEVEDQLFRFSRILDVQPRLAILLGDCAVPAEGRVRLLRKVLERA
DSTVNPVVVALLSHTVELLRGQAVEEAVLFLAEVAVARRGEIVAQVGAAAELSDAQRT
RLTEVLSRIYGHPVTVQLHIDAALLGGLSIAVGDEVIDGTLSSRLAAAEARLPD"
gene 1463228..1464877
/gene="atpA"
/locus_tag="Rv1308"
CDS 1463228..1464877
/codon_start=1
/transl_table=11
/gene="atpA"
/locus_tag="Rv1308"
/product="Probable ATP synthase alpha chain AtpA"
/note="Rv1308, (MTCY373.28), len: 549 aa. Probable
atpA,ATP synthase alpha chain, highly similar to
ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa),
FASTA scores: opt: 3233, E(): 0, (90.3% identity in 547 aa
overlap). Contains PS00017 ATP/GTP-binding site motif
A,PS00152 ATP synthase alpha and beta subunits signature.
subunit: F-type ATPases have 2 components, cf(1) - the
catalytic core - and cf(0) - the membrane proton channel.
cf(1) has five subunits: alpha(3), beta(3),
gamma(1),delta(1), epsilon(1). cf(0) has three main
subunits: A, B and C. Belongs to the ATPase alpha/beta
chains family."
/db_xref="EnsemblGenomes-Gn:Rv1308"
/db_xref="EnsemblGenomes-Tr:CCP44065"
/db_xref="GOA:P9WPU7"
/db_xref="InterPro:IPR000194"
/db_xref="InterPro:IPR000793"
/db_xref="InterPro:IPR004100"
/db_xref="InterPro:IPR005294"
/db_xref="InterPro:IPR020003"
/db_xref="InterPro:IPR023366"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR033732"
/db_xref="InterPro:IPR036121"
/db_xref="InterPro:IPR038376"
/db_xref="UniProtKB/Swiss-Prot:P9WPU7"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00152"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44065.1"
/translation="MAELTIPADDIQSAIEEYVSSFTADTSREEVGTVVDAGDGIAHV
EGLPSVMTQELLEFPGGILGVALNLDEHSVGAVILGDFENIEEGQQVKRTGEVLSVPV
GDGFLGRVVNPLGQPIDGRGDVDSDTRRALELQAPSVVHRQGVKEPLQTGIKAIDAMT
PIGRGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDPKKQVRCVYVAIGQKGTTIAA
VRRTLEEGGAMDYTTIVAAAASESAGFKWLAPYTGSAIAQHWMYEGKHVLIIFDDLTK
QAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDLGGGSLTGLPIIETKA
NDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGS
LRLDLSQYRELEAFAAFASDLDAASKAQLERGARLVELLKQPQSQPMPVEEQVVSIFL
GTGGHLDSVPVEDVRRFETELLDHMRASEEEILTEIRDSQKLTEEAADKLTEVIKNFK
KGFAATGGGSVVPDEHVEALDEDKLAKEAVKVKKPAPKKKK"
gene 1464884..1465801
/gene="atpG"
/locus_tag="Rv1309"
CDS 1464884..1465801
/codon_start=1
/transl_table=11
/gene="atpG"
/locus_tag="Rv1309"
/product="Probable ATP synthase gamma chain AtpG"
/note="Rv1309, (MTCY373.29), len: 305 aa. Probable
atpG,ATP synthase gamma chain, highly similar to
ATPG_MYCLE|P45824 ATP synthase gamma chain from
Mycobacterium leprae (298 aa), FASTA scores: opt:
1579,E():0, (83.9% identity in 305 aa overlap). Contains
PS00153 ATP synthase gamma subunit signature. subunit:
F-type ATPases have 2 components, cf(1) - the catalytic
core - and cf(0) - the membrane proton channel. cf(1) has
five subunits: alpha(3), beta(3), gamma(1),
delta(1),epsilon(1). cf(0) has three main subunits: A, B
and C. Belongs to the ATPase gamma chain family."
/db_xref="EnsemblGenomes-Gn:Rv1309"
/db_xref="EnsemblGenomes-Tr:CCP44066"
/db_xref="GOA:P9WPU9"
/db_xref="InterPro:IPR000131"
/db_xref="InterPro:IPR023632"
/db_xref="InterPro:IPR035968"
/db_xref="UniProtKB/Swiss-Prot:P9WPU9"
/inference="protein motif:PROSITE:PS00153"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44066.1"
/translation="MAATLRELRGRIRSAGSIKKITKAQELIATSRIARAQARLESAR
PYAFEITRMLTTLAAEAALDHPLLVERPEPKRAGVLVVSSDRGLCGAYNANIFRRSEE
LFSLLREAGKQPVLYVVGRKAQNYYSFRNWNITESWMGFSEQPTYENAAEIASTLVDA
FLLGTDNGEDQRSDSGEGVDELHIVYTEFKSMLSQSAEAHRIAPMVVEYVEEDIGPRT
LYSFEPDATMLFESLLPRYLTTRVYAALLESAASELASRQRAMKSATDNADDLIKALT
LMANRERQAQITQEISEIVGGANALAEAR"
gene 1465841..1467301
/gene="atpD"
/locus_tag="Rv1310"
CDS 1465841..1467301
/codon_start=1
/transl_table=11
/gene="atpD"
/locus_tag="Rv1310"
/product="Probable ATP synthase beta chain AtpD"
/note="Rv1310, (MTCY373.30), len: 486 aa. Probable
atpD,ATP synthase beta chain, highly similar to
ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA
score: opt: 2916, E(): 0, (92.6% identity in 484 aa
overlap). Contains PS00017 ATP/GTP-binding site motif
A,PS00152 ATP synthase alpha and beta subunits signature.
subunit: F-type ATPases have 2 components, cf(1) - the
catalytic core - and cf(0) - the membrane proton channel.
cf(1) has five subunits: alpha(3), beta(3),
gamma(1),delta(1), epsilon(1). cf(0) has three main
subunits: A, B and C. Belongs to the ATPase alpha/beta
chains family."
/db_xref="EnsemblGenomes-Gn:Rv1310"
/db_xref="EnsemblGenomes-Tr:CCP44067"
/db_xref="GOA:P9WPU5"
/db_xref="InterPro:IPR000194"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004100"
/db_xref="InterPro:IPR005722"
/db_xref="InterPro:IPR020003"
/db_xref="InterPro:IPR024034"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036121"
/db_xref="UniProtKB/Swiss-Prot:P9WPU5"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00152"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44067.1"
/translation="MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELF
NALHAEITFESLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVG
EGVKGHVFNALGDCLDEPGYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTP
YVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEA
NVLKDTALVFGQMDEPPGTRMRVALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSE
VSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATT
FAHLDATTELSRAVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKD
LQDIIAILGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAF
DRLCKGDFDHVPEQAFFLIGGLDDLAKKAESLGAKL"
gene 1467315..1467680
/gene="atpC"
/locus_tag="Rv1311"
CDS 1467315..1467680
/codon_start=1
/transl_table=11
/gene="atpC"
/locus_tag="Rv1311"
/product="Probable ATP synthase epsilon chain AtpC"
/note="Rv1311, (MTCY373.31), len: 121 aa. Probable
atpC,ATP synthase epsilon chain, highly similar to
ATPE_MYCLE|P45822 Mycobacterium leprae (124 aa), FASTA
scores: opt: 682, E(): 5.4e-40, (87.6% identity in 121 aa
overlap). subunit: F-type ATPases have 2 components, cf(1)
- the catalytic core - and cf(0) - the membrane proton
channel. cf(1) has five subunits: alpha(3),
beta(3),gamma(1), delta(1), epsilon(1). cf(0) has three
main subunits: A, B and C. Belongs to the ATPase epsilon
chain family."
/db_xref="EnsemblGenomes-Gn:Rv1311"
/db_xref="EnsemblGenomes-Tr:CCP44068"
/db_xref="GOA:P9WPV1"
/db_xref="InterPro:IPR001469"
/db_xref="InterPro:IPR020546"
/db_xref="InterPro:IPR036771"
/db_xref="PDB:2LX5"
/db_xref="PDB:5YIO"
/db_xref="UniProtKB/Swiss-Prot:P9WPV1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44068.1"
/translation="MAELNVEIVAVDRNIWSGTAKFLFTRTTVGEIGILPRHIPLVAQ
LVDDAMVRVEREGEKDLRIAVDGGFLSVTEEGVSILAESAEFESEIDEAAAKQDSESD
DPRIAARGRARLRAVGAID"
gene 1467688..1468131
/locus_tag="Rv1312"
CDS 1467688..1468131
/codon_start=1
/transl_table=11
/locus_tag="Rv1312"
/product="Conserved hypothetical secreted protein"
/note="Rv1312, (MTCY373.32), len: 147 aa. Conserved
hypothetical secreted protein with potential N-terminal
signal sequence. Highly similar to P53432|Y02W_MYCLE
hypothetical Mycobacterium leprae protein (147 aa), FASTA
score: opt: 884, E(): 0, (88.4% identity in 147 aa
overlap). N-terminus hydrophobic."
/db_xref="EnsemblGenomes-Gn:Rv1312"
/db_xref="EnsemblGenomes-Tr:CCP44069"
/db_xref="GOA:P9WM29"
/db_xref="InterPro:IPR019675"
/db_xref="UniProtKB/Swiss-Prot:P9WM29"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44069.1"
/translation="MSAPMIGMVVLVVVLGLAVLALSYRLWKLRQGGTAGIMRDIPAV
GGHGWRHGVIRYRGGEAAFYRLSSLRLWPDRRLSRRGVEIISRRAPRGDEFDIMTDEI
VVVELCDSTQDRRVGYEIALDRGALTAFLSWLESRPSPRARRRSM"
mobile_element complement(1468143..1469651)
/mobile_element_type="insertion sequence:IS1557-2"
/note="IS1557-2, len: 1509 nt. Insertion sequence IS1557."
repeat_region 1468143..1468161
/note="19 bp inverted repeat, GCAGACGCAAAAGCCCCCA, at the
left end of IS1557"
gene complement(1468171..1469505)
/locus_tag="Rv1313c"
CDS complement(1468171..1469505)
/codon_start=1
/transl_table=11
/locus_tag="Rv1313c"
/product="Possible transposase"
/note="Rv1313c, (MTCY373.33c), len: 444 aa. Possible
IS1557 transposase, similar to several transposases e.g.
U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium
DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3%
identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase
for insertion sequence element IS1001 from Bordetella
parapertussis (406 aa), FASTA scores: opt: 254, E():
3.3e-10, (24.9% identity in 402 aa overlap). Also similar
to putative Mycobacterium tuberculosis transposases,
Rv3798 and Rv0741."
/db_xref="EnsemblGenomes-Gn:Rv1313c"
/db_xref="EnsemblGenomes-Tr:CCP44070"
/db_xref="GOA:P9WKH7"
/db_xref="InterPro:IPR002560"
/db_xref="InterPro:IPR029261"
/db_xref="InterPro:IPR032877"
/db_xref="UniProtKB/Swiss-Prot:P9WKH7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44070.1"
/translation="MRNVRLFRALLGVDKRTVIEDIEFEEDDAGDGARVIARVRPRSA
VLRRCGRCGRKASWYDRGAGLRQWRSLDWGTVEVFLEAEAPRVNCPTHGPTVVAVPWA
RHHAGHTYAFDDTVAWLAVACSKTAVCELMRIAWRTVGAIVARVWADTEKRIDRFANL
RRIGIDEISYKRHHRYLTVVVDHDSGRLVWAAPGHDKATLGLFFDALGAERAAQITHV
SADAADWIADVVTERCPDAIQCADPFHVVAWATEALDVERRRAWNDARAIARTEPKWG
RGRPGKNAAPRPGRERARRLKGARYALWKNPEDLTERQSAKLAWIAKTDPRLYRAYLL
KESLRHVFSVKGEEGKQALDRWISWAQRCRIPVFVELAARIKRHRVAIDAALDHGLSQ
GLIESTNTKIRLLTRIAFGFRSPQALIALAMLTLAGHRPTLPGRHNHPQISQ"
repeat_region complement(1469633..1469651)
/note="19 bp inverted repeat, GCAGACGCGAAAGCCCCCA, at the
right end of IS1557. Single base difference at 3-end."
gene complement(1469671..1470252)
/locus_tag="Rv1314c"
CDS complement(1469671..1470252)
/codon_start=1
/transl_table=11
/locus_tag="Rv1314c"
/product="Conserved protein"
/note="Rv1314c, (MTCY373.34c), len: 193 aa. Conserved
protein, highly similar to P53523|Y02Y_MYCLE hypothetical
Mycobacterium leprae protein (191 aa), FASTA score:
opt:1019, E(): 0, (81.2% identity in 191 aa overlap). Some
similarity with YDHW_CITFR|P45515 hypothetical 19.8 kDa
protein in dhar-dhat intergenic region (176 aa), FASTA
scores: opt: 297, E(): 1.6e-13, (37.6% identity in 178 aa
overlap). Also similar to hypothetical protein
AE002007|AE002007_3 Deinococcus radiodurans (185 aa),
FASTA score: opt: 386, E(): 7.7e-19, (42.4% identity in
172 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1314c"
/db_xref="EnsemblGenomes-Tr:CCP44071"
/db_xref="GOA:P9WP99"
/db_xref="InterPro:IPR016030"
/db_xref="InterPro:IPR029499"
/db_xref="InterPro:IPR036451"
/db_xref="PDB:2G2D"
/db_xref="UniProtKB/Swiss-Prot:P9WP99"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44071.1"
/translation="MAVHLTRIYTRTGDDGTTGLSDMSRVAKTDARLVAYADCDEANA
AIGAALALGHPDTQITDVLRQIQNDLFDAGADLSTPIVENPKHPPLRIAQSYIDRLEG
WCDAYNAGLPALKSFVLPGGSPLSALLHVARTVVRRAERSAWAAVDAHPEGVSVLPAK
YLNRLSDLLFILSRVANPDGDVLWRPGGDRTAS"
gene 1470321..1471577
/gene="murA"
/locus_tag="Rv1315"
CDS 1470321..1471577
/codon_start=1
/transl_table=11
/gene="murA"
/locus_tag="Rv1315"
/product="Probable UDP-N-acetylglucosamine
1-carboxyvinyltransferase MurA"
/note="Rv1315, (MTCY373.35-MTCY149.01), len: 418 aa.
Probable murA, UDP-N-acetylglucosamine
1-carboxyvinyltransferase (see Belanger & Inamine
2000),highly similar to many e.g. MURA_MYCLE|P45821 (418
aa),FASTA scores: opt: 2495, E(): 0, (96.2% identity in
396 aa overlap). Belongs to the EPSP synthase family. MURA
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1315"
/db_xref="EnsemblGenomes-Tr:CCP44072"
/db_xref="GOA:P9WJM1"
/db_xref="InterPro:IPR001986"
/db_xref="InterPro:IPR005750"
/db_xref="InterPro:IPR013792"
/db_xref="InterPro:IPR036968"
/db_xref="UniProtKB/Swiss-Prot:P9WJM1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44072.1"
/translation="MAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITN
CPDILDVPLMAEVLRGLGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPL
VGRCKRARVALPGGDAIGSRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLE
FPSVGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITG
VPRLHPTEHRVIGDRIVAATWGIAAAMTRGDISVAGVDPAHLQLVLHKLHDAGATVTQ
TDASFRVTQYERPKAVNVATLPFPGFPTDLQPMAIALASIADGTSMITENVFEARFRF
VEEMIRLGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVHDV
FHIDRGYPLFVENLVSLGAEIERVCC"
gene 1471619..1471742
/gene="mcr3"
/gene_synonym="mpr7"
ncRNA 1471619..1471742
/gene="mcr3"
/gene_synonym="mpr7"
/product="Putative small regulatory RNA"
/note="mcr3, putative small regulatory RNA (See DiChiara
et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC
Pasteur, 3'-end not mapped."
/ncRNA_class="other"
gene 1471846..1473382
/gene="rrs"
rRNA 1471846..1473382
/gene="rrs"
/product="Ribosomal RNA 16S"
/note="rrs, 16s rRNA gene (alternate gene name: rrnS)."
gene 1473658..1476795
/gene="rrl"
rRNA 1473658..1476795
/gene="rrl"
/product="Ribosomal RNA 23S"
/note="rrl, 23S rRNA gene (approximate coordinates)."
gene 1476899..1477013
/gene="rrf"
rRNA 1476899..1477013
/gene="rrf"
/product="Ribosomal RNA 5S"
/note="rrf, 5S rRNA gene. Identical to Em_ba:MT5SRR,
D10035 M.tuberculosis 5S rRNA, len: 116."
gene complement(1477134..1477631)
/gene="ogt"
/gene_synonym="adaB"
/locus_tag="Rv1316c"
CDS complement(1477134..1477631)
/codon_start=1
/transl_table=11
/gene="ogt"
/gene_synonym="adaB"
/locus_tag="Rv1316c"
/product="Methylated-DNA--protein-cysteine
methyltransferase Ogt (6-O-methylguanine-DNA
methyltransferase) (O-6-methylguanine-DNA-
alkyltransferase)"
/note="Rv1316c, (MTCY130.01c), len: 165 aa.
Ogt,methylated-dna--protein-cysteine methytransferase (see
citation below), similar to many e.g. OGT_HAEIN|P44687
Haemophilus influenzae (190 aa), FASTA scores: opt:
405,E(): 6.5e-20, (41.9% identity in 155 aa overlap).
Contains PS00374 Methylated-DNA--protein-cysteine
methyltransferase active site."
/db_xref="EnsemblGenomes-Gn:Rv1316c"
/db_xref="EnsemblGenomes-Tr:CCP44073"
/db_xref="GOA:P9WJW5"
/db_xref="InterPro:IPR001497"
/db_xref="InterPro:IPR008332"
/db_xref="InterPro:IPR014048"
/db_xref="InterPro:IPR023546"
/db_xref="InterPro:IPR036217"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036631"
/db_xref="PDB:4BHB"
/db_xref="PDB:4BHC"
/db_xref="PDB:4WX9"
/db_xref="PDB:4WXC"
/db_xref="PDB:4WXD"
/db_xref="UniProtKB/Swiss-Prot:P9WJW5"
/inference="protein motif:PROSITE:PS00374"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44073.1"
/translation="MIHYRTIDSPIGPLTLAGHGSVLTNLRMLEQTYEPSRTHWTPDP
GAFSGAVDQLNAYFAGELTEFDVELDLRGTDFQQRVWKALLTIPYGETRSYGEIADQI
GAPGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGYGGGINRKRALLELEKSRAPAD
LTLFD"
gene complement(1477628..1479118)
/gene="alkA"
/gene_synonym="ada"
/locus_tag="Rv1317c"
CDS complement(1477628..1479118)
/codon_start=1
/transl_table=11
/gene="alkA"
/gene_synonym="ada"
/locus_tag="Rv1317c"
/product="Probable bifunctional regulatory protein and DNA
repair enzyme AlkA (regulatory protein of adaptative
response) (methylphosphotriester-DNA--protein-cysteine
S-methyltransferase)"
/note="Rv1317c, (MTCY130.02c), len: 496 aa. Probable alkA
(alternate gene name: ada), bifunctional regulatory
protein (see citation below) and DNA repair enzyme,
similar to 3MG2_ECOLI|P04395 dna-3-methyladenine
glycosidase II from Escherichia coli (282 aa), FASTA
scores, opt: 437, E(): 8.6e-22, (32.8% identity in 293 aa
overlap), also similar to other ada proteins e.g.
ADA_SALTY|P26189 Salmonella typhimurium (352 aa), FASTA
scores: E(): 5.3e-08, (35.9% identity in 156 aa overlap).
Contains PS00041 Bacterial regulatory proteins, araC
family signature."
/db_xref="EnsemblGenomes-Gn:Rv1317c"
/db_xref="EnsemblGenomes-Tr:CCP44074"
/db_xref="GOA:P9WJW3"
/db_xref="InterPro:IPR003265"
/db_xref="InterPro:IPR004026"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR010316"
/db_xref="InterPro:IPR011257"
/db_xref="InterPro:IPR018060"
/db_xref="InterPro:IPR018062"
/db_xref="InterPro:IPR023170"
/db_xref="InterPro:IPR035451"
/db_xref="InterPro:IPR037046"
/db_xref="UniProtKB/Swiss-Prot:P9WJW3"
/inference="protein motif:PROSITE:PS00041"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44074.1"
/translation="MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPF
ARNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDG
VSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAG
FSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGH
LAATAVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARC
RRLLDLDADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKA
ASTHAGRLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASL
ADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAAKK
LGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA"
gene complement(1479199..1480824)
/locus_tag="Rv1318c"
CDS complement(1479199..1480824)
/codon_start=1
/transl_table=11
/locus_tag="Rv1318c"
/product="Possible adenylate cyclase (ATP
pyrophosphate-lyase) (adenylyl cyclase)"
/note="Rv1318c, (MTCY130.03c), len: 541 aa. Possible
adenylate cyclase. Some similarity at the c-terminus to
CYAA_RHIME|P19485 adenylate cyclase from Rhizobium
meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11,
(28.8% identity in 184 aa overlap); similar to other
mycbacterium tuberculosis putative adenylate cyclases e.g.
Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505,
E(): 0, (71.0% identity in 534 aa overlap), also similar
to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423,
E(): 0, (68.7% identity in 534 aa overlap). N-terminus is
hydrophobic. Belongs to adenylyl cyclase class-3 family."
/db_xref="EnsemblGenomes-Gn:Rv1318c"
/db_xref="EnsemblGenomes-Tr:CCP44075"
/db_xref="GOA:P9WQ33"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/Swiss-Prot:P9WQ33"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44075.1"
/translation="MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQR
RRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLA
LALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTL
YGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILG
RTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILA
WLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLF
GRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAI
VVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAG
IGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEE
ERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR"
gene complement(1480894..1482501)
/locus_tag="Rv1319c"
CDS complement(1480894..1482501)
/codon_start=1
/transl_table=11
/locus_tag="Rv1319c"
/product="Possible adenylate cyclase (ATP
pyrophosphate-lyase) (adenylyl cyclase)"
/note="Rv1319c, (MTCY130.04c), len: 535 aa. Possible
adenylate cyclase. Some similarity at the C-terminus to
CYAA_RHIME|P19485 adenylate cyclase from Rhizobium
meliloti (193 aa), FASTA scores: opt: 254, E(): 2.4e-10,
(33.3% identity in 144 aa overlap); similar to other
mycbacterium tuberculosis putative adenylate cyclases e.g.
Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505,
E(): 0, (71.0% identity in 534 aa overlap);
Rv1320c|MTCY130.05c (567 aa), FASTA scores: opt: 2354,
E(): 0, (66.3% identity in 534 aa overlap). N-terminus is
hydrophobic. Belongs to adenylyl cyclase class-3 family."
/db_xref="EnsemblGenomes-Gn:Rv1319c"
/db_xref="EnsemblGenomes-Tr:CCP44076"
/db_xref="GOA:P9WQ31"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/Swiss-Prot:P9WQ31"
/protein_id="CCP44076.1"
/translation="MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPS
RRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLA
LAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLAT
LYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIM
GRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWIL
AWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDL
FGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFA
IVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQA
GIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASE
TERAHWSLGETVTLRGHEQPTRLAVPT"
gene complement(1482514..1484217)
/locus_tag="Rv1320c"
CDS complement(1482514..1484217)
/codon_start=1
/transl_table=11
/locus_tag="Rv1320c"
/product="Possible adenylate cyclase (ATP
pyrophosphate-lyase) (adenylyl cyclase)"
/note="Rv1320c, (MTCY130.05c), len: 567 aa. Possible
adenylate cyclase (see Rindi et al., 1999). Some
similarity at the C-terminus to CYAA_RHIME|P19485
adenylate cyclase from Rhizobium meliloti (193 aa), FASTA
scores: opt: 277,E(): 2e-12, (34.0% identity in 156 aa
overlap); similar to other mycbacterium tuberculosis
putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541
aa), FASTA scores: opt: 2423,E(): 0, (68.7% identity in
534 aa overlap); Rv1319c|MTCY130.04c (535 aa), FASTA
scores: opt: 2354, E(): 0, (66.3% identity in 534 aa
overlap). N-terminus is hydrophobic. Belongs to adenylyl
cyclase class-3 family."
/db_xref="EnsemblGenomes-Gn:Rv1320c"
/db_xref="EnsemblGenomes-Tr:CCP44077"
/db_xref="GOA:P9WQ29"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/Swiss-Prot:P9WQ29"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44077.1"
/translation="MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPR
MRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLA
FILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTII
YGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVG
RTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILA
WLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLF
GRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTV
IVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAG
IGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASEN
ECARWSLGETVTLRGHDQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPT
D"
gene 1484279..1484959
/locus_tag="Rv1321"
CDS 1484279..1484959
/codon_start=1
/transl_table=11
/locus_tag="Rv1321"
/product="Conserved hypothetical protein"
/note="Rv1321, (MTCY130.06), len: 226 aa. Conserved
hypothetical protein. Equivalent to P53524|YD21_MYCLE
hypothetical protein from Mycobacterium leprae (201
aa),FASTA scores: opt: 1144, E(): 0, (87.6% identity in
193 aa overlap). Some similarity to hypothetical proteins
from other organisms e.g. Y225_METJA|Q57678 Methanococcus
jannaschii (263 aa), FASTA scores: E(): 6.5e-05, (25.0%
identity in 212 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1321"
/db_xref="EnsemblGenomes-Tr:CCP44078"
/db_xref="GOA:P9WIY5"
/db_xref="InterPro:IPR002793"
/db_xref="InterPro:IPR011856"
/db_xref="UniProtKB/Swiss-Prot:P9WIY5"
/protein_id="CCP44078.1"
/translation="MSRVRLVIAQCTVDYIGRLTAHLPSARRLLLFKADGSVSVHADD
RAYKPLNWMSPPCWLTEESGGQAPVWVVENKAGEQLRITIEGIEHDSSHELGVDPGLV
KDGVEAHLQALLAEHIQLLGEGYTLVRREYMTAIGPVDLLCSDERGGSVAVEIKRRGE
IDGVEQLTRYLELLNRDSVLAPVKGVFAAQQIKPQARILATDRGIRCLTLDYDTMRGM
DSGEYRLF"
gene 1484982..1485278
/locus_tag="Rv1322"
CDS 1484982..1485278
/codon_start=1
/transl_table=11
/locus_tag="Rv1322"
/product="Conserved hypothetical protein"
/note="Rv1322, (MTCY130.07), len: 98 aa. Conserved
hypothetical protein."
/db_xref="EnsemblGenomes-Gn:Rv1322"
/db_xref="EnsemblGenomes-Tr:CCP44079"
/db_xref="UniProtKB/Swiss-Prot:P9WM27"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44079.1"
/translation="MARRRKPLHRQRPEPPSWALRRVEAGPDGHEYEVRPVAAARAVK
TYRCPGCDHEIRSGTAHVVVWPTDLPQAGVDDRRHWHTPCWANRATRGPTRKWT"
gene complement(1485313..1485771)
/locus_tag="Rv1322A"
CDS complement(1485313..1485771)
/codon_start=1
/transl_table=11
/locus_tag="Rv1322A"
/product="Conserved protein"
/note="Rv1322A, len: 152 aa. Conserved protein, similar to
proteins from Mycobacterium leprae and Streptomyces
coelicolor e.g. AL583921_2|ML1157 from M. leprae strain tn
(155 aa), FASTA scores: opt: 771, E(): 5.1e-43, (75.3%
identity in 154 aa overlap); and AL137242_2 from
Streptomyces coelicolor (146 aa), FASTA scores: opt:
404,E(): 2e-19, (43.165% identity in 139 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1322A"
/db_xref="EnsemblGenomes-Tr:CCP44080"
/db_xref="GOA:L7N6B1"
/db_xref="InterPro:IPR017515"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="PDB:6BU2"
/db_xref="UniProtKB/TrEMBL:L7N6B1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44080.1"
/translation="MMTTDQVHARHMLATSLVTGLDHVGIAVADLDVAIEWYHDHLGM
ILVHEEINDDQGIREALLAVPGSAAQIQLMAPLDESSVIAKFLDKRGPGIQQLACRVS
DLDAMCRRLRSQGVRLVYETARRGTANSRINFIHPKDAGGVLIELVEPAP"
gene 1485862..1487031
/gene="fadA4"
/locus_tag="Rv1323"
CDS 1485862..1487031
/codon_start=1
/transl_table=11
/gene="fadA4"
/locus_tag="Rv1323"
/product="Probable acetyl-CoA acetyltransferase FadA4
(acetoacetyl-CoA thiolase)"
/note="Rv1323, (MTCY130.08), len: 389 aa. Probable
fadA4,acetyl-CoA acetyltransferase, equivalent to
THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase
from Mycobacterium leprae (393 aa), FASTA scores: opt:
2218, E(): 0, (87.0% identity in 392 aa overlap). Also
highly similar to others e.g. CAB70629.1|AL137242 probable
acetoacetyl-CoA thiolase from Streptomyces coelicolor (401
aa); T51772 acetyl-CoA C-acetyltransferase [validated]
from Alcaligenes latus (392 aa); etc. Some homologies
indicate ATA start codon. Contains PS00098 Thiolases
acyl-enzyme intermediate signature, PS00737 Thiolases
signature 2, and PS00099 Thiolases active site. Belongs to
the thiolase family."
/db_xref="EnsemblGenomes-Gn:Rv1323"
/db_xref="EnsemblGenomes-Tr:CCP44081"
/db_xref="GOA:P9WG69"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020610"
/db_xref="InterPro:IPR020613"
/db_xref="InterPro:IPR020615"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/Swiss-Prot:P9WG69"
/inference="protein motif:PROSITE:PS00098"
/inference="protein motif:PROSITE:PS00737"
/inference="protein motif:PROSITE:PS00099"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44081.1"
/translation="MIVAGARTPIGKLMGSLKDFSASELGAIAIKGALEKANVPASLV
EYVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGIDAIALADQLIRARE
FDVVVAGGQESMTKAPHLLMNSRSGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQR
NDVDMFTRSEQDEYAAASHQKAAAAWKDGVFADEVIPVNIPQRTGDPLQFTEDEGIRA
NTTAAALAGLKPAFRGDGTITAGSASQISDGAAAVVVMNQEKAQELGLTWLAEIGAHG
VVAGPDSTLQSQPANAINKALDREGISVDQLDVVEINEAFAAVALASIRELGLNPQIV
NVNGGAIAVGHPLGMSGTRITLHAALQLARRGSGVGVAALCGAGGQGDALILRAG"
gene 1487161..1488075
/locus_tag="Rv1324"
CDS 1487161..1488075
/codon_start=1
/transl_table=11
/locus_tag="Rv1324"
/product="Possible thioredoxin"
/note="Rv1324, (MTCY130.09), len: 304 aa. Possible
thioredoxin, similar to several e.g. U00014|Q49716 TRXA
from Mycobacterium leprae (255 aa), FASTA scores: opt:
1014, E(): 0, (69.7% identity in 228 aa overlap);
THIO_RHOSH|P08058 TrxA from Rhodobacter sphaeroides (105
aa), FASTA scores: opt 196, E(): 1.9e-06, (33.0% identity
in 103 aa overlap). Contains PS00339 Aminoacyl-transfer
RNA synthetases class-II signature 2. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1324"
/db_xref="EnsemblGenomes-Tr:CCP44082"
/db_xref="GOA:P9WG61"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/Swiss-Prot:P9WG61"
/inference="protein motif:PROSITE:PS00339"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44082.1"
/translation="MTRPRPPLGPAMAGAVDLSGIKQRAQQNAAASTDADRALSTPSG
VTEITEANFEDEVIVRSDEVPVVVLLWSPRSEVCVDLLDTLSGLAAAAKGKWSLASVN
VDVAPRVAQIFGVQAVPTVVALAAGQPISSFQGLQPADQLSRWVDSLLSATAGKLKGA
ASSEESTEVDPAVAQARQQLEDGDFVAARKSYQAILDANPGSVEAKAAIRQIEFLIRA
TAQRPDAVSVADSLSDDIDAAFAAADVQVLNQDVSAAFERLIALVRRTSGEERTRVRT
RLIELFELFDPADPEVVAGRRNLANALY"
gene complement(1488154..1489965)
/gene="PE_PGRS24"
/locus_tag="Rv1325c"
CDS complement(1488154..1489965)
/codon_start=1
/transl_table=11
/gene="PE_PGRS24"
/locus_tag="Rv1325c"
/product="PE-PGRS family protein PE_PGRS24"
/note="Rv1325c, (MTCY130.10c), len: 603 aa.
PE_PGRS24,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of ala-, gly-rich proteins (see
Brennan & Delogu 2002), similar to many e.g.
YQ04_MYCTU|P71933 hypothetical 63.1 kDa glycine-rich
protein (778 aa), FASTA scores: E(): 0, (52.3% identity in
724 aa overlap). Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1325c"
/db_xref="EnsemblGenomes-Tr:CCP44083"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIF7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44083.1"
/translation="MSFVIAAPETLVRAASDLANIGSTLGAANAAALGPTTELLAAGA
DEVSAAIASLFAAHGQAYQAVSAQMSAFHAQFVQTFTAGAGAYASAEAAAAAPLEGLL
NIVNTPTQLLLGRPLIGNGANGAPGTGQAGGAGGLLYGNGGAGGSGAPGQAGGPGGAA
GLFGNGGAGGAGGDGPGNGAAGGAGGAGGLLFGSGGAGGPGGVGNTGTGGLGGDGGAA
GLFGAGGIGGAGGPGFNGGAGGAGGRSGLFEVLAAGGAGGTGGLSVNGGTGGTGGTGG
GGGLFSNGGAGGAGGFGVSGSAGGNGGTGGDGGIFTGNGGTGGTGGTGTGNQLVGGEG
GAGGAGGNAGILFGAGGIGGTGGTGLGAPDPGGTGGKGGVGGIGGAGALFGPGGAGGT
GGFGASSADQMAGGIGGSGGSGGAAKLIGDGGAGGTGGDSVRGAAGSGGTGGTGGLIG
DGGAGGAGGTGIEFGSVGGAGGAGGNAAGLSGAGGAGGAGGFGETAGDGGAGGNAGLL
NGDGGAGGAGGLGIAGDGGNGGKGGKAGMVGNGGDGGAGGASVVANGGVGGSGGNATL
IGNGGNGGNGGVGSAPGKGGAGGTAGLLGLNGSPGLS"
gene complement(1490117..1492312)
/gene="glgB"
/locus_tag="Rv1326c"
CDS complement(1490117..1492312)
/codon_start=1
/transl_table=11
/gene="glgB"
/locus_tag="Rv1326c"
/product="1,4-alpha-glucan branching enzyme GlgB (glycogen
branching enzyme)"
/note="Rv1326c, (MTCY130.11c), len: 731 aa.
glgB,1,4-alpha-glucan branching enzyme, similar to others
e.g. GLGB_ECOLI|P07762 Escherichia coli (728 aa), FASTA
scores: opt: 2330, E(): 0, (48.7% identity in 719 aa
overlap). Similar to other Mycobacterium tuberculosis
putative alpha-glucan branching enzymes Rv1562c, Rv1563c.
Belongs to family 13 of glycosyl hydrolases, also known as
the alpha-amylase family."
/db_xref="EnsemblGenomes-Gn:Rv1326c"
/db_xref="EnsemblGenomes-Tr:CCP44084"
/db_xref="GOA:P9WN45"
/db_xref="InterPro:IPR004193"
/db_xref="InterPro:IPR006047"
/db_xref="InterPro:IPR006048"
/db_xref="InterPro:IPR006407"
/db_xref="InterPro:IPR013780"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR014756"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR037439"
/db_xref="PDB:3K1D"
/db_xref="UniProtKB/Swiss-Prot:P9WN45"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44084.1"
/translation="MSRSEKLTGEHLAPEPAEMARLVAGTHHNPHGILGAHEYDDHTV
IRAFRPHAVEVVALVGKDRFSLQHLDSGLFAVALPFVDLIDYRLQVTYEGCEPHTVAD
AYRFLPTLGEVDLHLFAEGRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVS
LIGEFNGWNGHEAPMRVLGPSGVWELFWPDFPCDGLYKFRVHGADGVVTDRADPFAFG
TEVPPQTASRVTSSDYTWGDDDWMAGRALRNPVNEAMSTYEVHLGSWRPGLSYRQLAR
ELTDYIVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQA
GIGVIVDWVPAHFPKDAWALGRFDGTPLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFL
VANALYWLQEFHIDGLRVDAVASMLYLDYSRPEGGWTPNVHGGRENLEAVQFLQEMNA
TAHKVAPGIVTIAEESTPWSGVTRPTNIGGLGFSMKWNMGWMHDTLDYVSRDPVYRSY
HHHEMTFSMLYAFSENYVLPLSHDEVVHGKGTLWGRMPGNNHVKAAGLRSLLAYQWAH
PGKQLLFMGQEFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDINDIYRCHPALWSL
DTTPEGYSWIDANDSANNVLSFMRYGSDGSVLACVFNFAGAEHRDYRLGLPRAGRWRE
VLNTDATIYHGSGIGNLGGVDATDDPWHGRPASAVLVLPPTSALWLTPA"
gene complement(1492320..1494425)
/gene="glgE"
/locus_tag="Rv1327c"
CDS complement(1492320..1494425)
/codon_start=1
/transl_table=11
/gene="glgE"
/locus_tag="Rv1327c"
/product="Probable glucanase GlgE"
/note="Rv1327c, (MTCY130.12c), len: 701 aa. Probable
glgE,glucanase, similar to AF172946|AF172946_2 putative
glucanase GlgE from Mycobacterium smegmatis (697 aa),
FASTA scores: opt: 3816, E(): 0, (78.5% identity in 692 aa
overlap). Similar to putative alpha-amylases e.g. Q9L1K2
Streptomyces coelicolor (675 aa), FASTA scores: opt:
2243,E(): 7.4e-132, (54.2% identity in 684 aa overlap).
Start changed since original submission (-36) based on
similarity to GlgE of Mycobacterium smegmatis; previous
start at position 1494531."
/db_xref="EnsemblGenomes-Gn:Rv1327c"
/db_xref="EnsemblGenomes-Tr:CCP44085"
/db_xref="GOA:P9WQ17"
/db_xref="InterPro:IPR006047"
/db_xref="InterPro:IPR013780"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR021828"
/db_xref="InterPro:IPR026585"
/db_xref="UniProtKB/Swiss-Prot:P9WQ17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44085.1"
/translation="MSGRAIGTETEWWVPGRVEIDDVAPVVSCGVYPAKAVVGEVVPV
SAAVWREGHEAVAATLVVRYLGVRYPHLTDRPRARVLPTPSEPQQRVKPLLIPMTSGQ
EPFVFHGQFTPDRVGLWTFRVDGWGDPIHTWRHGLIAKLDAGQGETELSNDLLVGAVL
LERAATGVPRGLRDPLLAAAAALRTPGDPVTRTALALTPEIEELLADYPLRDLVTRGE
QFGVWVDRPLARFGAWYEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYL
PPIHPIGKVHRKGRNNSPTAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAA
RDLGMEVALDLALQCAPDHPWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDND
PEGLYDEVLRVVQHWVNHGVKFFRVDNPHTKPPNFWAWLIAQVKTVDPDVLFLSEAFT
PPARQYGLAKLGFTQSYSYFTWRTTKWELTEFGNQIAELADYRRPNLFVNTPDILHAV
LQHNGPGMFAIRAVLAATMSPAWGMYCGYELFEHRAVREGSEEYLDSEKYELRPRDFA
SALDQGRSLQPFITRLNIIRRLHPAFQQLRTIHFHHVDNDALLAYSKFDPATGDCVLV
VVTLNAFGPEEATLWLDMAALGMEDYDRFWVRDEITGEEYQWGQANYIRIDPARAVAH
IINMPAVPYESRNTLLRRR"
gene 1494564..1497155
/gene="glgP"
/locus_tag="Rv1328"
CDS 1494564..1497155
/codon_start=1
/transl_table=11
/gene="glgP"
/locus_tag="Rv1328"
/product="Probable glycogen phosphorylase GlgP"
/note="Rv1328, (MTCY130.13), len: 863 aa. Probable
glgP,glycogen phosphorylase, similar to many e.g.
PHSG_HAEIN|P45180 glycogen phosphorylase from Haemophilus
influenzae (821 aa), FASTA scores: E(): 6.9e-08, (25.6%
identity in 675 aa overlap). Belongs to the glycogen
phosphorylase family."
/db_xref="EnsemblGenomes-Gn:Rv1328"
/db_xref="EnsemblGenomes-Tr:CCP44086"
/db_xref="GOA:P9WMW1"
/db_xref="InterPro:IPR000811"
/db_xref="InterPro:IPR011834"
/db_xref="InterPro:IPR024517"
/db_xref="InterPro:IPR035090"
/db_xref="UniProtKB/Swiss-Prot:P9WMW1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44086.1"
/translation="MKALRRFTVRAHLPERLAALDQLSTNLRWSWDKPTQDLFAAIDP
ALWEQCGHDPVALLGAVNPARLDELALDAEFLGALDELAADLNDYLSRPLWYQEQQDA
GVAAQALPTGIAYFSLEFGVAEVLPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRS
GYFRQSLTADGWQHETYPSLDPQGLPLRLLTDANGDPVLVEVALGDNAVLRARIWVAQ
VGRVPLLLLDSDIPENEHDLRNVTDRLYGGDQEHRIKQEILAGIGGVRAIRAYTAVEK
LTPPEVFHMNEGHAGFLGIERIRELVTDAGLDFDTALTVVRSSTVFTTHTPVPAGIDR
FPLEMVQRYVNDQRGDGRSRLLPGLPADRIVALGAEDDPAKFNMAHMGLRLAQRANGV
SLLHGRVSRAMFNELWAGFDPDEVPIGSVTNGVHAPTWAAPQWLQLGRELAGSDSLRE
PVVWQRLHQVDPAHLWWIRSQLRSMLVEDVRARLRQSWLERGATDAELGWIATAFDPN
VLTVGFARRVPTYKRLTLMLRDPDRLEQLLLDEQRPIQLIVAGKSHPADDGGKALIQQ
VVRFADRPQVRHRIAFLPNYDMSMARLLYWGCDVWLNNPLRPLEACGTSGMKSALNGG
LNLSIRDGWWDEWYDGENGWEIPSADGVADENRRDDLEAGALYDLLAQAVAPKFYERD
ERGVPQRWVEMVRHTLQTLGPKVLASRMVRDYVEHYYAPAAQSFRRTAGAQFDAAREL
ADYRRRAEEAWPKIEIADVDSTGLPDTPLLGSQLTLTATVRLAGLRPNDVTVQGVLGR
VDAGDVLMDPVTVEMAHTGTGDGGYEIFSTTTPLPLAGPVGYTVRVLPRHPMLAASNE
LGLVTLA"
gene complement(1497195..1499189)
/gene="dinG"
/locus_tag="Rv1329c"
CDS complement(1497195..1499189)
/codon_start=1
/transl_table=11
/gene="dinG"
/locus_tag="Rv1329c"
/product="Probable ATP-dependent helicase DinG"
/note="Rv1329c, (MTCY130.14c), len: 664 aa. Probable
dinG,ATP-dependent helicase (see citation below), similar
to several e.g. DING_HAEIN|P44680 probable ATP-dependent
helicase ding from Haemophilus influenzae (640 aa), FASTA
scores: opt: 685, E(): 2.3e-38, (32.8% identity in 644 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A."
/db_xref="EnsemblGenomes-Gn:Rv1329c"
/db_xref="EnsemblGenomes-Tr:CCP44087"
/db_xref="GOA:P9WMR5"
/db_xref="InterPro:IPR006555"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR014013"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WMR5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44087.1"
/translation="MSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEH
LVVQAGTGTGKSLAYLVPAIIRALCDDAPVVVSTATIALQRQLVDRDLPQLVDSLTNA
LPRRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTALGRDVQRLTA
WASTTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADV
VVTNHALLAIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRIT
RLVDPKVTQRLQAASATFSSAIHDARPGRIDCLDDEMATYLSALRDAASAARSAIDTG
SDTTTASVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVWLEHEDNHESARAVLRV
APLSVAELLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQH
AKSGILYVAAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMR
ERLSTPVLCQGDDSTSTLVEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFP
RPDDPLLSARQRAVAARGGNGFMTVAASHAALLLAQGSGRLLRRVTDRGVVAVLDSRM
ATARYGEFLRASLPPFWQTTNATQVRAALRRLARADAKAH"
gene complement(1499213..1500559)
/gene="pncB1"
/locus_tag="Rv1330c"
CDS complement(1499213..1500559)
/codon_start=1
/transl_table=11
/gene="pncB1"
/locus_tag="Rv1330c"
/product="Nicotinic acid phosphoribosyltransferase PncB1"
/note="Rv1330c, (MTCY130.15c), len: 448 aa.
PncB1,nicotinic acid phosphoribosyltransferase (See
Boshoff et al., 2008). Similar to e.g. O32090 YUEK protein
from Bacillus subtilis (490 aa), FASTA scores: E():
8.6e-22,(37.9% identity in 369 aa overlap). Also similar
to Mycobacterium tuberculosis Rv0573c|MTV039.11c (38.0%
identity in 437 aa overlap). Start changed since original
submission based on similarity; previous start at position
1500740 (-61 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1330c"
/db_xref="EnsemblGenomes-Tr:CCP44088"
/db_xref="GOA:P9WJI9"
/db_xref="InterPro:IPR002638"
/db_xref="InterPro:IPR006405"
/db_xref="InterPro:IPR007229"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR036068"
/db_xref="InterPro:IPR040727"
/db_xref="UniProtKB/Swiss-Prot:P9WJI9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44088.1"
/translation="MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRP
TTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFR
FRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAA
GGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLH
AQHGGPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSG
ELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAP
TANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVE
PHRVLTLPLVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA"
gene 1500661..1500966
/locus_tag="Rv1331"
CDS 1500661..1500966
/codon_start=1
/transl_table=11
/locus_tag="Rv1331"
/product="Conserved hypothetical protein"
/note="Rv1331, (MTCY130.16), len: 101 aa. Conserved
hypothetical protein, highly similar to U00014|ML014
B1549_C2_207 from Mycobacterium leprae (94 aa), FASTA
scores: opt: 573, E(): 2.9e-40, (90.3% identity in 93 aa
overlap). Similar to AL096852|SCE19A_16 hypothetical
protein from Streptomyces coelicolor (105 aa), FASTA
scores: opt: 377, E(): 2.9e-22, (60.0% identity in 105 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1331"
/db_xref="EnsemblGenomes-Tr:CCP44089"
/db_xref="GOA:P9WPC1"
/db_xref="InterPro:IPR003769"
/db_xref="InterPro:IPR014719"
/db_xref="InterPro:IPR022935"
/db_xref="UniProtKB/Swiss-Prot:P9WPC1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44089.1"
/translation="MAVVSAPAKPGTTWQRESAPVDVTDRAWVTIVWDDPVNLMSYVT
YVFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR"
gene 1500926..1501582
/locus_tag="Rv1332"
CDS 1500926..1501582
/codon_start=1
/transl_table=11
/locus_tag="Rv1332"
/product="Probable transcriptional regulatory protein"
/note="Rv1332, (MTCY130.17), len: 218 aa. Possible
regulatory protein, high similarity to ML014|U00014 M.
leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158,
E(): 0, (75.6% identity in 221 aa overlap). Helix turn
helix motif fram aa 8-29 (+3.03 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1332"
/db_xref="EnsemblGenomes-Tr:CCP44090"
/db_xref="InterPro:IPR018561"
/db_xref="UniProtKB/Swiss-Prot:P9WM25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44090.1"
/translation="MPPVCGRRCSRTGEIRGYSGSIVRRWKRVETRDGPRFRSSLAPH
EAALLKNLAGAMIGLLDDRDSSSPSDELEEITGIKTGHAQRPGDPTLRRLLPDFYRPD
DLDDDDPTAVDGSESFNAALRSLHEPEIIDAKRVAAQQLLDTVPDNGGRLELTESDAN
AWIAAVNDLRLALGVMLEIGPRGPERLPGNHPLAAHFNVYQWLTVLQEYLVLVLMGSR
"
gene 1501599..1502633
/locus_tag="Rv1333"
CDS 1501599..1502633
/codon_start=1
/transl_table=11
/locus_tag="Rv1333"
/product="Probable hydrolase"
/note="Rv1333, (MTCY130.18), len: 344 aa. Possible
hydrolase, similar to Q57326|D26094 endo-type
6-aminohexanoate oligomer hydrolase (355 aa), fasta
scores: E(): 1.4e-10, (31.9% identity in 339 aa overlap).
Equivalent to P53425|YD33_MYCLE hypothetical 36.1 KD
protein B154 Mycobacterium leprae (362 aa), FASTA scores:
opt: 1735, E(): 0, (76.7% identity in 352 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1333"
/db_xref="EnsemblGenomes-Tr:CCP44091"
/db_xref="GOA:P9WM23"
/db_xref="InterPro:IPR005321"
/db_xref="InterPro:IPR016117"
/db_xref="UniProtKB/Swiss-Prot:P9WM23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44091.1"
/translation="MNSITDVGGIRVGHYQRLDPDASLGAGWACGVTVVLPPPGTVGA
VDCRGGAPGTRETDLLDPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMD
SGVVPIVPGAVIFDLPVGGWNCRPTADFGYSACAAAGVDVAVGTVGVGVGARAGALKG
GVGTASATLQSGVTVGVLAVVNAAGNVVDPATGLPWMADLVGEFALRAPPAEQIAALA
QLSSPLGAFNTPFNTTIGVIACDAALSPAACRRIAIAAHDGLARTIRPAHTPLDGDTV
FALATGAVAVPPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTY
RDMFPGAFGS"
gene 1502641..1503081
/gene="mec"
/locus_tag="Rv1334"
CDS 1502641..1503081
/codon_start=1
/transl_table=11
/gene="mec"
/locus_tag="Rv1334"
/product="Possible hydrolase"
/note="Rv1334, (MTCY130.19), len: 146 aa. Possible
mec,hydrolase (See Burns et al., 2005), similar to
AL096852|SCE19A_13 hypothetical protein from Streptomyces
coelicolor (140 aa), Fasta scores: opt: 579, E(): 0,
(65.0% identity in 140 aa overlap); and Q54330|M29166 MEC+
from Streptomyces kasugaensis (115 aa), FASTA scores; E():
7.6e-33, (56.9% identity in 109 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1334"
/db_xref="EnsemblGenomes-Tr:CCP44092"
/db_xref="GOA:P9WHS1"
/db_xref="InterPro:IPR000555"
/db_xref="InterPro:IPR028090"
/db_xref="InterPro:IPR037518"
/db_xref="UniProtKB/Swiss-Prot:P9WHS1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44092.1"
/translation="MLLRKGTVYVLVIRADLVNAMVAHARRDHPDEACGVLAGPEGSD
RPERHIPMTNAERSPTFYRLDSGEQLKVWRAMEDADEVPVVIYHSHTATEAYPSRTDV
KLATEPDAHYVLVSTRDPHRHELRSYRIVDGAVTEEPVNVVEQY"
gene 1503103..1503384
/gene="cysO"
/gene_synonym="cfp10A"
/locus_tag="Rv1335"
CDS 1503103..1503384
/codon_start=1
/transl_table=11
/gene="cysO"
/gene_synonym="cfp10A"
/locus_tag="Rv1335"
/product="Sulfur carrier protein CysO"
/note="Rv1335, (MT1376.1, MTCY130.20), len: 93 aa.
CysO,sulfur carrier protein (See Burns et al., 2005). Note
that previously known as cfp10A. Similar to hypothetical
proteins from other organisms e.g. P74060|D90911
Synechocystis (109 aa), FASTA scores: E(): 2.3e-20, (49.5%
identity in 93 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1335"
/db_xref="EnsemblGenomes-Tr:CCP44093"
/db_xref="GOA:P9WP33"
/db_xref="InterPro:IPR003749"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR016155"
/db_xref="PDB:3DWG"
/db_xref="PDB:3DWM"
/db_xref="UniProtKB/Swiss-Prot:P9WP33"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44093.1"
/translation="MNVTVSIPTILRPHTGGQKSVSASGDTLGAVISDLEANYSGISE
RLMDPSSPGKLHRFVNIYVNDEDVRFSGGLATAIADGDSVTILPAVAGG"
gene 1503394..1504365
/gene="cysM"
/locus_tag="Rv1336"
CDS 1503394..1504365
/codon_start=1
/transl_table=11
/gene="cysM"
/locus_tag="Rv1336"
/product="Cysteine synthase B CysM (CSASE B)
(O-phosphoserine sulfhydrylase B) (O-phosphoserine
(thiol)-lyase B)"
/note="Rv1336, (MTCY130.21), len: 323 aa. cysM, cysteine
synthase B, similar to many e.g. CYSM_ECOLI|P16703
Escherichia coli (303 aa), FASTA scores: opt: 720, E():
4.6e-40, (41.1% identity in 302 aa overlap). Also similar
to other Mycobacterium tuberculosis cysteine synthase
subunits e.g. Rv1077, Rv2334, Rv0848, etc. Contains
PS00901 Cysteine synthase/cystathionine beta-synthase
P-phosphate attachment site. Belongs to the cysteine
synthase/cystathionine beta-synthase family."
/db_xref="EnsemblGenomes-Gn:Rv1336"
/db_xref="EnsemblGenomes-Tr:CCP44094"
/db_xref="GOA:P9WP53"
/db_xref="InterPro:IPR001216"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR005856"
/db_xref="InterPro:IPR036052"
/db_xref="PDB:3DKI"
/db_xref="PDB:3DWG"
/db_xref="PDB:3DWI"
/db_xref="PDB:3FGP"
/db_xref="PDB:5I6D"
/db_xref="PDB:5I7A"
/db_xref="PDB:5I7H"
/db_xref="PDB:5I7O"
/db_xref="PDB:5I7R"
/db_xref="PDB:5IW8"
/db_xref="PDB:5IWC"
/db_xref="UniProtKB/Swiss-Prot:P9WP53"
/inference="protein motif:PROSITE:PS00901"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44094.1"
/translation="MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDR
NPTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMP
ENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDS
HYCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYA
LRNMDEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGV
GAGALAAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA"
gene 1504356..1505078
/locus_tag="Rv1337"
CDS 1504356..1505078
/codon_start=1
/transl_table=11
/locus_tag="Rv1337"
/product="Probable integral membrane protein"
/note="Rv1337, (MTCY130.22), len: 240 aa. Probable
integral membrane protein. Highly similar to P53426
hypothetical protein B1549_C3_240 from M.leprae (251); and
P74553|D90916 hypothetical protein from Synechocystis sp.
(198 aa), FASTA scores: E(): 2.3e-25, (43.6% identity in
181 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1337"
/db_xref="EnsemblGenomes-Tr:CCP44095"
/db_xref="GOA:P9WM21"
/db_xref="InterPro:IPR022764"
/db_xref="InterPro:IPR035952"
/db_xref="UniProtKB/Swiss-Prot:P9WM21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44095.1"
/translation="MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTIL
TFVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGVIFAPLLHANWHHLMANTIPLLV
LGFLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLL
VFGLFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLL
SAPERKARALKRAGARSGHPKL"
gene 1505075..1505890
/gene="murI"
/locus_tag="Rv1338"
CDS 1505075..1505890
/codon_start=1
/transl_table=11
/gene="murI"
/locus_tag="Rv1338"
/product="Probable glutamate racemase MurI"
/note="Rv1338, (MTCY130.23), len: 271 aa. Probable
murI,glutamate racemase, highly similar to many e.g.
MURI_MYCLE|P46705 (272 aa), FASTA scores: opt: 1559, E():
0, (88.9% identity in 271 aa overlap). Contains PS00924
Aspartate and glutamate racemases signature 2."
/db_xref="EnsemblGenomes-Gn:Rv1338"
/db_xref="EnsemblGenomes-Tr:CCP44096"
/db_xref="GOA:P9WPW9"
/db_xref="InterPro:IPR001920"
/db_xref="InterPro:IPR004391"
/db_xref="InterPro:IPR015942"
/db_xref="InterPro:IPR018187"
/db_xref="InterPro:IPR033134"
/db_xref="PDB:5HJ7"
/db_xref="UniProtKB/Swiss-Prot:P9WPW9"
/inference="protein motif:PROSITE:PS00924"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44096.1"
/translation="MNSPLAPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPY
GPLTIPEIRAHALAIGDDLVGRGVKALVIACNSASSACLRDARERYQVPVVEVILPAV
RRAVAATRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGR
QVLGLAQGYLEPLQRAEVDTLVLGCTHYPLLSGLIQLAMGENVTLVSSAEETAKEVVR
VLTEIDLLRPHDAPPATRIFEATGDPEAFTKLAARFLGPVLGGVQPVHPSRIH"
gene 1505917..1506738
/locus_tag="Rv1339"
CDS 1505917..1506738
/codon_start=1
/transl_table=11
/locus_tag="Rv1339"
/product="Conserved protein"
/note="Rv1339, (MTCY130.24), len: 273 aa. Conserved
protein, highly similar to Y211_MYCLE|P50474 hypothetical
protein b1549_c2_211 from Mycobacterium leprae (284
aa),FASTA scores: opt: 1672, E(): 0, (86.2% identity in
276 aa overlap). Also similar to AL096852|SCE19A.08
hypothetical protein from Streptomyces coelicolor (250
aa), FASTA scores: opt: 630, E(): 0, (42.2% identity in
256 aa overlap). Similar to M. tuberculosis hypothetical
proteins Rv3796, Rv2407. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1339"
/db_xref="EnsemblGenomes-Tr:CCP44097"
/db_xref="GOA:P9WGC1"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/Swiss-Prot:P9WGC1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44097.1"
/translation="MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAP
HTPPLVIDFGGGVLGALQRHADPASVHVLLSHLHADHCLDLPGLFVWRRYHPSRPSGK
ALLYGPSDTWSRLGAASSPYGGEIDDCSDIFDVHHWADSEPVTLGALTIVPRLVAHPT
ESFGLRITDPSGASLAYSGDTGICDQLVELARGVDVFLCEASWTHSPKHPPDLHLSGT
EAGMVAAQAGVRELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG"
gene 1506755..1507534
/gene="rphA"
/locus_tag="Rv1340"
CDS 1506755..1507534
/codon_start=1
/transl_table=11
/gene="rphA"
/locus_tag="Rv1340"
/product="Probable ribonuclease RphA (RNase PH) (tRNA
nucleotidyltransferase)"
/note="Rv1340, (MTCY130.25), len: 259 aa. Probable
rphA,Ribonuclease ph, highly similar to others e.g.
RNPH_MYCLE|P37939 Mycobacterium leprae (259 aa), FASTA
scores: opt: 1524, E(): 0, (88.8% identity in 259 aa
overlap). Belongs to the RNASE PH family."
/db_xref="EnsemblGenomes-Gn:Rv1340"
/db_xref="EnsemblGenomes-Tr:CCP44098"
/db_xref="GOA:P9WGZ7"
/db_xref="InterPro:IPR001247"
/db_xref="InterPro:IPR002381"
/db_xref="InterPro:IPR015847"
/db_xref="InterPro:IPR018336"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR027408"
/db_xref="InterPro:IPR036345"
/db_xref="PDB:3B4T"
/db_xref="UniProtKB/Swiss-Prot:P9WGZ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44098.1"
/translation="MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTAS
VTEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRESVRGRLSGRTQEISRLIGRSLRA
CIDLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSC
AIAAVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLD
KLLDMALGACDTLFAAQRDALALPYPGVLPQGPPPPKAFGT"
repeat_region 1507531..1507581
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 1507573..1508187
/locus_tag="Rv1341"
CDS 1507573..1508187
/codon_start=1
/transl_table=11
/locus_tag="Rv1341"
/product="Conserved protein"
/note="Rv1341, (MTCY130.26), len: 204 aa. Conserved
protein, some similarity to P52061|YGGV_ECOLI hypothetical
protein yggV (197 aa), FASTA scores: opt: 521, E():
7.9e-27, (46.0% identity in 200 aa overlap). Equivalent to
ML014|U00014 hypothetical protein B1549_C2_213 from
Mycobacterium leprae (285 aa), FASTA scores: opt:
1073,E(): 0, (83.0% identity in 206 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1341"
/db_xref="EnsemblGenomes-Tr:CCP44099"
/db_xref="GOA:P9WMR7"
/db_xref="InterPro:IPR002637"
/db_xref="InterPro:IPR020922"
/db_xref="InterPro:IPR029001"
/db_xref="UniProtKB/Swiss-Prot:P9WMR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44099.1"
/translation="MALVTKLLVASRNRKKLAELRRVLDGAGLSGLTLLSLGDVSPLP
ETPETGVTFEDNALAKARDAFSATGLASVADDSGLEVAALGGMPGVLSARWSGRYGDD
AANTALLLAQLCDVPDERRGAAFVSACALVSGSGEVVVRGEWPGTIAREPRGDGGFGY
DPVFVPYGDDRTAAQLSPAEKDAVSHRGRALALLLPALRSLATG"
gene complement(1508184..1508546)
/locus_tag="Rv1342c"
CDS complement(1508184..1508546)
/codon_start=1
/transl_table=11
/locus_tag="Rv1342c"
/product="Conserved membrane protein"
/note="Rv1342c, (MTCY02B10.06c), len: 120 aa. Conserved
membrane protein. Highly similar to G466926|P54133
hypothetical protein B1549_F2_59 from Mycobacterium leprae
(119 aa), FASTA scores, opt: 544, E(): 1.9e-29, (68.3 %
identity in 120 aa overlap). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv1342c"
/db_xref="EnsemblGenomes-Tr:CCP44100"
/db_xref="GOA:P9WM19"
/db_xref="InterPro:IPR023845"
/db_xref="UniProtKB/Swiss-Prot:P9WM19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44100.1"
/translation="MTAPETPAAQHAEPAIAVERIRTALLGYRIMAWTTGLWLIALCY
EIVVRYVVKVDNPPTWIGVVHGWVYFTYLLLTLNLAVKVRWPLGKTAGVLLAGTIPLL
GIVVEHFQTKEIKARFGL"
gene complement(1508543..1508923)
/gene="lprD"
/locus_tag="Rv1343c"
CDS complement(1508543..1508923)
/codon_start=1
/transl_table=11
/gene="lprD"
/locus_tag="Rv1343c"
/product="Probable conserved lipoprotein LprD"
/note="Rv1343c, (MTCY02B10.07c), len: 126 aa. Probable
lprD, conserved lipoprotein, highly similar to G466928
Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA
scores, opt: 704, E(): 7.5e-36, (78.4 % identity in 125 aa
overlap). Has N-terminal signal sequence and appropriately
positioned prokaryotic lipoprotein attachment site.
Contains PS00013 Prokaryotic membrane lipoprotein lipid
attachment site. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1343c"
/db_xref="EnsemblGenomes-Tr:CCP44101"
/db_xref="GOA:P9WK51"
/db_xref="UniProtKB/Swiss-Prot:P9WK51"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44101.1"
/translation="MSTTRRRRPALIALVIIATCGCLALGWWQWTRFQSTSGTFQNLG
YALQWPLFAWFCVYAYRNFVRYEETPPQPPTGGAAAEIPAGLLPERPKPAQQPPDDPV
LREYNAYLAELAKDDARKQNRTTA"
gene 1508968..1509288
/gene="mbtL"
/locus_tag="Rv1344"
CDS 1508968..1509288
/codon_start=1
/transl_table=11
/gene="mbtL"
/locus_tag="Rv1344"
/product="Acyl carrier protein (ACP) MbtL"
/note="Rv1344, (MTCY02B10.08), len: 106 aa. mbtL, acyl
carrier protein, similar to others e.g. ACP_RHIME|P19372
Rhizobium meliloti (77 aa), FASTA scores: opt: 117, E():
0.03, (29.9% identity in 67 aa overlap) and
ACP_SYNY3|P20804 acyl carrier protein (acp) from
Synechocystis sp (77 aa), FASTA scores: E():
7.1e-05,(34.8% identity in 66 aa overlap). Also similar to
Rv2244 and Rv0033 from Mycobacterium tuberculosis. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1344"
/db_xref="EnsemblGenomes-Tr:CCP44102"
/db_xref="GOA:P9WQF1"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/Swiss-Prot:P9WQF1"
/protein_id="CCP44102.1"
/translation="MWRYPLSTRLALPNTPGVASFAMTSSPSTVSTTLLSILRDDLNI
DLTRVTPDARLVDDVGLDSVAFAVGMVAIEERLGVALSEEELLTCDTVGELEAAIAAK
YRDE"
gene 1509281..1510846
/gene="mbtM"
/gene_synonym="fadD33"
/locus_tag="Rv1345"
CDS 1509281..1510846
/codon_start=1
/transl_table=11
/gene="mbtM"
/gene_synonym="fadD33"
/locus_tag="Rv1345"
/product="Probable fatty acyl-AMP ligase MbtM"
/note="Rv1345, (MTCY02B10.09), len: 521 aa. Probable
mbtM,fatty acyl-AMP ligase. Similar to N-terminus of
T34918 polyketide synthase from Streptomyces coelicolor
(2297 aa); and PKSJ_BACSU|P40806 putative polyketide
biosynthesis protein from Bacillus subtilis (557 aa),
FASTA scores: opt: 537, E(): 8.2e-27, (27.1% identity in
468 aa overlap). Also similar to other proteins from
Mycobacterium tuberculosis eg
Rv1013|MTCI237.30|MTCY10G2.36c|pks16 putative polyketide
synthase (544 aa); etc. Note that previously known as
fadD33."
/db_xref="EnsemblGenomes-Gn:Rv1345"
/db_xref="EnsemblGenomes-Tr:CCP44103"
/db_xref="GOA:P9WQ41"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ41"
/protein_id="CCP44103.1"
/translation="MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESV
AAWLLDHDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLT
RFLGIGVRTVLSQGSYLARLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTA
GSTGAPRTAILSPGAVLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAG
APLWLAPTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVT
LNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPGIGLLADRVID
GSGAHKHAVLGNPIPGMEVRISCGDQAAGNASREIGEIEIRGASMMAGYLGQQPIDPD
DWFATGDLGYLGAGGLVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGT
GDRSTRPGLVVAAEFRGPDEANARAELIQRVASECGIVPSDVVFVSPGSLPRTSSGKL
RRLAVRRSLEMAD"
gene 1510846..1512006
/gene="mbtN"
/gene_synonym="fadE14"
/locus_tag="Rv1346"
CDS 1510846..1512006
/codon_start=1
/transl_table=11
/gene="mbtN"
/gene_synonym="fadE14"
/locus_tag="Rv1346"
/product="Acyl-CoA dehydrogenase MbtN"
/note="Rv1346, (MTCY02B10.10), len: 386 aa. mbtN, acyl-CoA
dehydrogenase, similar to many e.g. NP_251579.1|NC_002516
probable acyl-CoA dehydrogenase from Pseudomonas
aeruginosa (386 aa); NP_036951.1|NM_012819|ACDL_RAT|P15650
acyl Coenzyme A dehydrogenase (long chain) from Rattus
norvegicus (430 aa), FASTA scores: opt: 414, E():
1.2e-18,(26.1% identity in 376 aa overlap); etc. Note that
previously known as fadE14."
/db_xref="EnsemblGenomes-Gn:Rv1346"
/db_xref="EnsemblGenomes-Tr:CCP44104"
/db_xref="GOA:P9WQF9"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="PDB:4XVX"
/db_xref="UniProtKB/Swiss-Prot:P9WQF9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44104.1"
/translation="MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLG
VCGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYL
RDICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADH
IMVVARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADA
LVARAGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQAL
RLRMADLQARVDLLRYALHGIAEQGRLELRTAAAVKVTAARLGEEVISECMHIFGGAG
YLVDETTLGKWWRDMKLARVGGGTDEVLWELVAAGMTPDHDGYAAVVGASKA"
gene complement(1511973..1512605)
/gene="mbtK"
/locus_tag="Rv1347c"
CDS complement(1511973..1512605)
/codon_start=1
/transl_table=11
/gene="mbtK"
/locus_tag="Rv1347c"
/product="Lysine N-acetyltransferase MbtK"
/note="Rv1347c, (MTCY02B10.11c), len: 210 aa. MbtK, lysine
N-acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain. See Vetting et al. 2005. Some
similarity to the C-terminus of malonyl-coenzyme A
carboxylases e.g. G545170 malonyl-coenzyme A carboxylase
(417 aa), FASTA scores: opt: 392, E(): 4.9 e-20, (35.6%
identity in 174 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1347c"
/db_xref="EnsemblGenomes-Tr:CCP44105"
/db_xref="GOA:P9WK15"
/db_xref="InterPro:IPR016181"
/db_xref="InterPro:IPR019432"
/db_xref="PDB:1YK3"
/db_xref="UniProtKB/Swiss-Prot:P9WK15"
/protein_id="CCP44105.1"
/translation="MTKPTSAGQADDALVRLARERFDLPDQVRRLARPPVPSLEPPYG
LRVAQLTDAEMLAEWMNRPHLAAAWEYDWPASRWRQHLNAQLEGTYSLPLIGSWHGTD
GGYLELYWAAKDLISHYYDADPYDLGLHAAIADLSKVNRGFGPLLLPRIVASVFANEP
RCRRIMFDPDHRNTATRRLCEWAGCKFLGEHDTTNRRMALYALEAPTTAA"
gene 1512728..1512811
/gene="leuW"
tRNA 1512728..1512811
/gene="leuW"
/product="tRNA-Leu"
/anticodon=(pos:1512762..1512764,aa:Leu,seq:tag)
/note="codon recognized: CUA; leuW, tRNA-Leu, anticodon
tag, length = 84"
gene 1513047..1515626
/gene="irtA"
/locus_tag="Rv1348"
CDS 1513047..1515626
/codon_start=1
/transl_table=11
/gene="irtA"
/locus_tag="Rv1348"
/product="Iron-regulated transporter IrtA"
/note="Rv1348, (MTCY02B10.12), len: 859 aa.
IrtA,iron-regulated transporter. Probable transmembrane
protein,similar to HMT1_SCHPO|Q02592 heavy metal tolerance
protein precursor from Schizosaccharomyces pombe (830 aa),
FASTA scores: opt: 806, E(): 5.1e-39, (32.9% identity in
504 aa overlap); etc. Also similar to MTCY02B10.13 from
Mycobacterium tuberculosis, FASTA score: (31.9% identity
in 576 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop), and PS00211 ABC transporters family
signature. Belongs to the ATP-binding transport protein
family (ABC transporters). Cofactor: FAD"
/db_xref="EnsemblGenomes-Gn:Rv1348"
/db_xref="EnsemblGenomes-Tr:CCP44106"
/db_xref="GOA:P9WQJ9"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR007037"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR013113"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="InterPro:IPR039261"
/db_xref="UniProtKB/Swiss-Prot:P9WQJ9"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44106.1"
/translation="MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQ
DAEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWAR
TVKPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYL
EQHDDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVR
VRLRDEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGS
WRAQAASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVG
FAAVGLLGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKK
LVTDDTLALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSS
LTIQSGPRIVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQ
RPLAGKKTLMDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGI
AYGLGGLRTGLLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVP
VIQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADEL
YTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVL
GANSGLSGGERQRLTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVL
VIAHRLHTITRADQIVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQD
GTR"
gene 1515623..1517362
/gene="irtB"
/locus_tag="Rv1349"
CDS 1515623..1517362
/codon_start=1
/transl_table=11
/gene="irtB"
/locus_tag="Rv1349"
/product="Iron-regulated transporter IrtB"
/note="Rv1349, (MTCY02B10.13), len: 579 aa.
IrtB,iron-regulated transporter. Probable transmembrane
protein,most similar to YWJA_BACSU|P45861 hypothetical ABC
transporter from Bacillus subtilis (575 aa), FASTA scores:
opt: 721, E(): 1.8e-35, (28.9% identity in 567 aa
overlap); etc. Also similar to MTCY02B10.12 from
Mycobacterium tuberculosis, FASTA score: (31.9% identity
in 576 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop), and PS00211 ABC transporters family
signature. Belongs to the ATP-binding transport protein
family (ABC transporters). Predicted possible vaccine
candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1349"
/db_xref="EnsemblGenomes-Tr:CCP44107"
/db_xref="GOA:P9WQJ7"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="UniProtKB/Swiss-Prot:P9WQJ7"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44107.1"
/translation="MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAA
LFGEAPQRAWLWLGWLSAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRL
DWFTAENTATARQAIAATGPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAA
LAGVPLLLGALWASAAFARRADTAADKANTALTERIIEFARTQQALRAARRVEPARSL
VGNALASQHTATMRLLGMQIPGQLLFSIASQLALIVLAGTTAALTITGTLTVPEAIAL
IVVMVRYLEPFTAVSELAPALESTRATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEF
DDVAFGYDGGSGPVLDGVSFCLQPGTTTAIVGPSGCGKSTILALIAGLHQPTRGRVLI
DGTDVATLDARAQQAVCSVVFQHPYLFHGTIRDNVFAADPGASDDQFAQAVRLARVDE
LIARLPDGANTIVGEAGSALSGGERQRVSIARALLKAAPVLLVDEATSALDAENEAAV
VDALAADPRSRTRVIVAHRLASIRHADRVLFVDDGRVVEDGSISELLTAGGRFSQFWR
QQHEAAEWQILAE"
gene 1517491..1518234
/gene="fabG2"
/locus_tag="Rv1350"
CDS 1517491..1518234
/codon_start=1
/transl_table=11
/gene="fabG2"
/locus_tag="Rv1350"
/product="Probable 3-oxoacyl-[acyl-carrier protein]
reductase FabG2 (3-ketoacyl-acyl carrier protein
reductase)"
/note="Rv1350, (MTCY02B10.14), len: 247 aa. Probable
fabG2,3-oxoacyl-[acyl-carrier protein] reductase, highly
similar to many e.g. NP_350157.1|NC_003030 3-ketoacyl-acyl
carrier protein reductase from Clostridium acetobutylicum
(249 aa); NP_229523.1|NC_000853 3-oxoacyl-(acyl carrier
protein) reductase from Thermotoga maritima (246 aa);
AAC44307.1|U59433 3-ketoacyl-acyl carrier protein
reductase from Bacillus subtilis (246 aa); etc. Contains
PS00061 Short-chain dehydrogenases/reductases family
signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1350"
/db_xref="EnsemblGenomes-Tr:CCP44108"
/db_xref="GOA:P9WGR9"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGR9"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44108.1"
/translation="MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEAT
EVAAKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTM
TEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKA
GIVGMTKAAAKELAHLGIRVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSE
VASVAVFLASDLSSYMTGTVLDVTGGRFI"
gene 1518231..1518560
/locus_tag="Rv1351"
CDS 1518231..1518560
/codon_start=1
/transl_table=11
/locus_tag="Rv1351"
/product="Hypothetical protein"
/note="Rv1351, (MTCY02B10.15), len: 109 aa. Hypothetical
unknown protein. Predicted to be an outer membrane protein
(See Song et al., 2008). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1351"
/db_xref="EnsemblGenomes-Tr:CCP44109"
/db_xref="UniProtKB/Swiss-Prot:P9WM17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44109.1"
/translation="MTPRSLPRYGNSSRRKSFPMHRPSNVATATRKKSSIGWVLLACS
VAGCKGIDTTEFILGRAGAFELAVRAAQHRHRYLTMVNVGRAPPRRCRTVCMAATDTP
RNIRLNG"
gene 1518763..1519134
/locus_tag="Rv1352"
CDS 1518763..1519134
/codon_start=1
/transl_table=11
/locus_tag="Rv1352"
/product="Conserved protein"
/note="Rv1352, (MTCY02B10.16), len: 123 aa. Conserved
protein, some similarity to Rv1906c|MTCY180.12
hypothetical protein from Mycobacterium tuberculosis (156
aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1352"
/db_xref="EnsemblGenomes-Tr:CCP44110"
/db_xref="GOA:P9WM15"
/db_xref="UniProtKB/Swiss-Prot:P9WM15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44110.1"
/translation="MARTLALRASAGLVAGMAMAAITLAPGARAETGEQFPGDGVFLV
GTDIAPGTYRTEGPSNPLILVFGRVSELSTCSWSTHSAPEVSNENIVDTNTSMGPMSV
VIPPTVAAFQTHNCKLWMRIS"
gene complement(1519200..1519985)
/locus_tag="Rv1353c"
CDS complement(1519200..1519985)
/codon_start=1
/transl_table=11
/locus_tag="Rv1353c"
/product="Probable transcriptional regulatory protein"
/note="Rv1353c, (MTCY02B10.17c), len: 261 aa. Probable
transcriptional regulatory protein, similar to
TER1_ECOLI|P03038 tetracycline repressor protein class a
from Escherichia coli (216 aa), FASTA scores, opt:
231,E(): 1.6e-08, (31.3% identity in 211 aa overlap).
Helix turn helix motif present at aa 3859 (+3.59 SD).
Belongs to the TetR/AcrR family of transcriptional
regulators."
/db_xref="EnsemblGenomes-Gn:Rv1353c"
/db_xref="EnsemblGenomes-Tr:CCP44111"
/db_xref="GOA:P9WMD3"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR004111"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/Swiss-Prot:P9WMD3"
/protein_id="CCP44111.1"
/translation="MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGK
HLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTF
ADNPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRG
SVVLDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLE
CILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR"
gene complement(1520005..1521876)
/locus_tag="Rv1354c"
CDS complement(1520005..1521876)
/codon_start=1
/transl_table=11
/locus_tag="Rv1354c"
/product="Conserved hypothetical protein"
/note="Rv1354c, (MTCY02B10.18c), len: 623 aa. Conserved
hypothetical protein, similar to many hypothetical
proteins e.g. the C-terminus of G1001455 Synechocystis sp.
(1244 aa), FASTA scores: opt: 933, E(): 0, (36.8% identity
in 462 aa overlap); also similar to Rv1357c|MTCY02B10.21c
(34.0% identity in 253 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1354c"
/db_xref="EnsemblGenomes-Tr:CCP44112"
/db_xref="GOA:P9WM13"
/db_xref="InterPro:IPR000160"
/db_xref="InterPro:IPR001633"
/db_xref="InterPro:IPR003018"
/db_xref="InterPro:IPR029016"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR035919"
/db_xref="UniProtKB/Swiss-Prot:P9WM13"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44112.1"
/translation="MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQL
GVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLV
FRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNAL
MTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALF
LDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSAD
AAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKH
AGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALV
RWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINV
SAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHI
AIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVV
AEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS"
gene complement(1521885..1524032)
/gene="moeY"
/locus_tag="Rv1355c"
CDS complement(1521885..1524032)
/codon_start=1
/transl_table=11
/gene="moeY"
/locus_tag="Rv1355c"
/product="Possible molybdopterin biosynthesis protein
MoeY"
/note="Rv1355c, (MTCY02B10.19c), len: 715 aa. Possible
moeY, Molybdopterin biosynthesis protein, very weak
similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis
moeb protein (249 aa), FASTA scores, opt: 180, E():
8.5e-05, (29.3% identity in 174 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1355c"
/db_xref="EnsemblGenomes-Tr:CCP44113"
/db_xref="GOA:P9WM11"
/db_xref="InterPro:IPR000415"
/db_xref="InterPro:IPR000594"
/db_xref="InterPro:IPR035985"
/db_xref="UniProtKB/Swiss-Prot:P9WM11"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44113.1"
/translation="MTIPHEGGSTGILVLRDDDHDDVLVLDRLRSDPSIEFVDRFAEQ
LAGVRRLLPQPDPDLLEEAKRWAYYPWRRMVVAILGLRGFRAVRLDRNRHLITAEEQR
ALHALRVGVVGLSAGHAIAYTLAAEGACGTLRLADFDKIELSNLNRVPVGVFDIGLNK
AMIAARRIAELDPYLAVDLVTSGLSPESVDEFLDGLDVVIEECDSLDIKVILRQAACA
RGVPVLMATSDRGLVDVERYDVEPGRPIFHGLLGDIDADKLCGLTTKDKVPHVLNILD
CQELSARCAASMIEVDQTLWGWPQLAGDIWVGAATVAEAVRRIGLGEPLESGRVRVDV
SAALDRLDQPPMPSRGNGWLLESVPPTAPAEPQPTSEIVAQAAIRAPSGGNVQPWHVV
AKQHSLTIRLAPEHTSAMDIAFRGSAVAVGAAMFNARVAAAAHRVLGSVEFDESQPDS
PLQATMHFGRGDDPSLAALYRPMLLRTTNRHHGMPGHVHPATVELLTNTAAAEGARLQ
LLLSRNEIDRAATILAAADRIRYLTPRLHEEMMSELRWPGDPSLDAGIDVRSLELDSG
ELRVLDILRRSDVVARLAQWDCGTALEDNTNERVSASSALAIVYVDGATLTDFARGGS
AMQAVWIVAQQHGLAVQPMSPIFLYARGRHDLDQASPHFAAQLHRLQLDFRELVKPGK
EGHEVLIFRLFHAPPPSVCSRRRVRHAIPEPHR"
gene complement(1524029..1524820)
/locus_tag="Rv1356c"
CDS complement(1524029..1524820)
/codon_start=1
/transl_table=11
/locus_tag="Rv1356c"
/product="Hypothetical protein"
/note="Rv1356c, (MTCY02B10.20c), len: 263 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1356c"
/db_xref="EnsemblGenomes-Tr:CCP44114"
/db_xref="UniProtKB/Swiss-Prot:P9WM09"
/protein_id="CCP44114.1"
/translation="MLIAGYLTDWRIMTTAQLRPIAPQKLHFSENLSVWVSDAQCRLV
VSQPALDPTLWNTYLQGALRAYSKHGVECTLDLDAISDGSDTQLFFAAIDIGGDVVGG
ARVIGPLRSADDSHAVVEWAGNPGLSAVRKMINDRAPFGVVEVKSGWVNSDAQRSDAI
AAALARALPLSMSLLGVQFVMGTAAAHALDRWRSSGGVIAARIPAAAYPDERYRTKMI
WWDRRTLANHAEPKQLSRMLVESRKLLRDVEALSATTAATAGAEQ"
gene complement(1525293..1526216)
/locus_tag="Rv1357c"
CDS complement(1525293..1526216)
/codon_start=1
/transl_table=11
/locus_tag="Rv1357c"
/product="Conserved hypothetical protein"
/note="Rv1357c, (MTCY02B10.21c), len: 307 aa. Conserved
hypothetical protein, similar to members of the
YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical
protein Y4ll from Rhizobium sp. (827 aa), FASTA scores:
E(): 0, (37.7% identity in 257 aa overlap), also similar
to Rv1354c|MTCY02B10.18c (34.0% identity in 253 aa
overlap). Belongs to the YEGE/YHDA/YHJK/YJCC family."
/db_xref="EnsemblGenomes-Gn:Rv1357c"
/db_xref="EnsemblGenomes-Tr:CCP44115"
/db_xref="GOA:P9WM07"
/db_xref="InterPro:IPR001633"
/db_xref="InterPro:IPR035919"
/db_xref="UniProtKB/Swiss-Prot:P9WM07"
/protein_id="CCP44115.1"
/translation="MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWA
DSDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTL
LPGRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGF
LVLVEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFS
SLAYLPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVET
PSQAARLRAFGCKAAQGWHFAKALPVDFFRE"
gene 1526612..1530091
/locus_tag="Rv1358"
CDS 1526612..1530091
/codon_start=1
/transl_table=11
/locus_tag="Rv1358"
/product="Probable transcriptional regulatory protein"
/note="Rv1358, (MTCY02B10.22), len: 1159 aa. Probable
transcriptional regulatory protein, some similarity to
AFSR_STRCO|P25941 regulatory protein afsr from
Streptomyces coelicolor (993 aa), FASTA scores: opt: 210,
E(): 5.5e-06,(27.5% identity in 739 aa overlap). Similar
also to Rv0890C|MTCY31.18c (65.5% identity in 884 aa
overlap) and to Rv1359|MTCY02B10.23 (43.7% identity in 197
aa overlap). Contains PS00017 ATP/GTP-binding site motif
A, PS00622 Bacterial regulatory proteins, luxR family
signature. Helix turn helix motif present at aa 1116-1137,
(Score 1291,+3.59 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1358"
/db_xref="EnsemblGenomes-Tr:CCP44116"
/db_xref="GOA:Q11028"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:Q11028"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00622"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44116.1"
/translation="MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIAD
QIARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLN
ELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLA
PMRPRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPAN
TWLTDVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQ
INEVQEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTT
AAHALGLIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSI
LATSRESIGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFDAVSEICRR
LDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYAL
LTDTERILFRRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEE
SRGSTRYRLLETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLL
QAEAEIDNLRAAFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDN
HLVPAGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVA
CGCGSGCDTEAAQPYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQ
ARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGL
YVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASE
ASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARV
AIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAA
AQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRG
ERKRPSNGWDALTPAEHKIVKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTS
RVQLVQEAAQHST"
gene 1530173..1530925
/locus_tag="Rv1359"
CDS 1530173..1530925
/codon_start=1
/transl_table=11
/locus_tag="Rv1359"
/product="Probable transcriptional regulatory protein"
/note="Rv1359, (MTCY02B10.23), len: 250 aa. Probable
transcriptional regulatory protein, similar to
Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and
to Rv1358|MTCY02B10.22 (43.7% identity in 197 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1359"
/db_xref="EnsemblGenomes-Tr:CCP44117"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/Swiss-Prot:P9WM05"
/protein_id="CCP44117.1"
/translation="MFMALRAPMLERMNGLHTDDAPVNWLERRGGRLTSRRRVTLLHA
GVEHPMRLWGVQSEAITAAMVLSRKVSAIIAGHCGVRLVDQGVGDGFVAAFAHASDAV
ACALELHQAPLSPIVLRIGIHTGEAQLVDERIYAGATMNLAAELRDLAHGGQTVMSGA
TEDAVLGRLPMRAWLIGLRPMEGSPEGHNFPQSQRIAQLCHPNLRNTFPPLRMRIADA
SGIPYVGRILVNVQVVPHWEGGCAAAGMVLAG"
gene 1531348..1532370
/locus_tag="Rv1360"
CDS 1531348..1532370
/codon_start=1
/transl_table=11
/locus_tag="Rv1360"
/product="Probable oxidoreductase"
/note="Rv1360, (MTCY02B10.24), len: 340 aa. Probable
oxidoreductase. Similar to Q49598|G1002714 coenzyme
F420-dependent n5, n10-methylenetetrahydromethanopterin
reductase from Methanopyrus kandleri (349 aa), FASTA
scores: opt: 264, E(): 4.4e-11, (26.3% identity in 323 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1360"
/db_xref="EnsemblGenomes-Tr:CCP44118"
/db_xref="GOA:P9WM03"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019919"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/Swiss-Prot:P9WM03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44118.1"
/translation="MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEASHDP
FLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILGLGTQIRPHI
EKRFSMPWGHPARRMREFVAALRAIWLAWQDGTKLCFEGEFYTHKIMTPMFTPEPQPY
PVPRVFIAAVGEAMTEMCGEVADGHLGHPMVSKRYLTEVSVPALLRGLARSGRDRSAF
EVSCEVMVATGADDAELAAACTATRKQIAFYGSTPAYRKVLEQHGWGDLHPELHRLSK
LGEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRVLPIFMAASQECINAA
LQDFRR"
gene complement(1532443..1533633)
/gene="PPE19"
/gene_synonym="mtb39b"
/locus_tag="Rv1361c"
CDS complement(1532443..1533633)
/codon_start=1
/transl_table=11
/gene="PPE19"
/gene_synonym="mtb39b"
/locus_tag="Rv1361c"
/product="PPE family protein PPE19"
/note="Rv1361c, (MTCY02B10.25c), len: 396 aa. PPE19
(alternate gene name: mtb39b). Member of the Mycobacterium
tuberculosis PPE family of glycine-rich proteins, highly
similar to many e.g. Rv1196|MTCI364.08|PPE18, FASTA
scores: E(): 0, (84.9% identity in 397 aa overlap);
MTCY274.23c (42.3% identity in 416 aa overlap); etc.
Contains PS00501 Signal peptidases I serine active site.
Note that expression of Rv1361c was demonstrated in
lysates by immunodetection (see Dillon et al., 1999). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1361c"
/db_xref="EnsemblGenomes-Tr:CCP44119"
/db_xref="GOA:P9WI25"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI25"
/inference="protein motif:PROSITE:PS00501"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44119.1"
/translation="MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAAS
AFQSVVWGLTTGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAY
GLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAA
TATEALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSI
WPFDQLSELWKAISPHLSPLSNIVSMLNNHVSMTNSGVSMASTLHSMLKGFAPAAAQA
VETAAQNGVQAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAV
TPAARALPLTSLTSAAQTAPGHMLGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRV
PAAG"
gene complement(1533948..1534610)
/locus_tag="Rv1362c"
CDS complement(1533948..1534610)
/codon_start=1
/transl_table=11
/locus_tag="Rv1362c"
/product="Possible membrane protein"
/note="Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible
membrane protein, similar to Mycobacterium tuberculosis
hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9%
identity in 216 aa overlap), Rv0177, Rv1973, Rv1972, etc."
/db_xref="EnsemblGenomes-Gn:Rv1362c"
/db_xref="EnsemblGenomes-Tr:CCP44120"
/db_xref="GOA:P9WM01"
/db_xref="UniProtKB/Swiss-Prot:P9WM01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44120.1"
/translation="MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATES
TAQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYRPDQQTDSGAARAA
VAAASDGTIALLSYSPDTLDQDFATARSHLAGDFLSYYDQFTQQIVAPAAKQKSLKTT
AKVVRAAVSELHPDSAVVLVFVDQSTTSKDSPNPSMAASSVMVTLAKVDGNWLITKFT
PV"
gene complement(1534607..1535392)
/locus_tag="Rv1363c"
CDS complement(1534607..1535392)
/codon_start=1
/transl_table=11
/locus_tag="Rv1363c"
/product="Possible membrane protein"
/note="Rv1363c, (MTCY02B10.27c), len: 261 aa. Possible
membrane protein, similar to Mycobacterium tuberculosis
hypothetical proteins Rv1362c|MTCY02B10.26c (25.9%
identity in 216 aa overlap); Rv1972|MTV051.10 and Rv0177
etc."
/db_xref="EnsemblGenomes-Gn:Rv1363c"
/db_xref="EnsemblGenomes-Tr:CCP44121"
/db_xref="GOA:P9WLZ9"
/db_xref="UniProtKB/Swiss-Prot:P9WLZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44121.1"
/translation="MAETTEPPSDAGTSQADAMALAAEAEAAEAEALAAAARARARAA
RLKREALAMAPAEDENVPEEYADWEDAEDYDDYDDYEAADQEAARSASWRRRLRVRLP
RLSTIAMAAAVVIICGFTGLSGYIVWQHHEATERQQRAAAFAAGAKQGVINMTSLDFN
KAKEDVARVIDSSTGEFRDDFQQRAADFTKVVEQSKVVTEGTVNATAVESMNEHSAVV
LVAATSRVTNSAGAKDEPRAWRLKVTVTEEGGQYKMSKVEFVP"
gene complement(1535417..1535716)
/gene="mcr15"
ncRNA complement(1535417..1535716)
/gene="mcr15"
/product="Putative small regulatory RNA"
/note="mcr15, putative small regulatory RNA (See DiChiara
et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC
Pasteur, 3'-end not mapped."
/ncRNA_class="other"
gene complement(1535683..1537644)
/locus_tag="Rv1364c"
CDS complement(1535683..1537644)
/codon_start=1
/transl_table=11
/locus_tag="Rv1364c"
/product="Possible sigma factor regulatory protein"
/note="Rv1364c, (MTCY02B10.28c), len: 653 aa. Possible
sigma factor regulatory protein, some similarity to
RSBU_BACSU|P40399 sigma factor sibg regulation protein
from Bacillus subtilis (335 aa), FASTA scores: opt: 224,
E(): 2e-07, (25.8% identity in 244 aa overlap). Also known
as mursiF."
/db_xref="EnsemblGenomes-Gn:Rv1364c"
/db_xref="EnsemblGenomes-Tr:CCP44122"
/db_xref="GOA:P9WLZ7"
/db_xref="InterPro:IPR000014"
/db_xref="InterPro:IPR000700"
/db_xref="InterPro:IPR001932"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR013656"
/db_xref="InterPro:IPR035965"
/db_xref="InterPro:IPR036457"
/db_xref="InterPro:IPR036513"
/db_xref="InterPro:IPR036890"
/db_xref="PDB:3K3C"
/db_xref="PDB:3K3D"
/db_xref="PDB:3KE6"
/db_xref="PDB:3KX0"
/db_xref="UniProtKB/Swiss-Prot:P9WLZ7"
/protein_id="CCP44122.1"
/translation="MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAA
YRGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVE
ERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATV
MQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVE
AAAVMSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQY
CTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERP
GRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLL
AMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAV
EHGYATDVSKGIVVAAALAGDGNVRASVIDRGQWKDHRDGARGRGRGLAMAEALVSEA
RIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVD
STTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVA
PPGSPAHHVLSLVQLPVVGADTEDIFAQE"
gene complement(1537783..1538169)
/gene="rsfA"
/locus_tag="Rv1365c"
CDS complement(1537783..1538169)
/codon_start=1
/transl_table=11
/gene="rsfA"
/locus_tag="Rv1365c"
/product="Anti-anti-sigma factor RsfA (anti-sigma factor
antagonist) (regulator of sigma F A)"
/note="Rv1365c, (MTCY02B10.29c), len: 128 aa.
RsfA,anti-anti-sigma factor (see citation below), similar
to other Mycobacterium tuberculosis proteins e.g.
Rv2638|MTCY441.08 (148 aa), FASTA scores: E(): 0, (53.6%
identity in 125 aa overlap); Rv1904, Rv3687c. Weak
similarity to putative anti-anti-sigma factors e.g.
AF134889|AF134889_1 Streptomyces coelicolor (113 aa),
FASTA scores: opt: 137, E(): 0.004, (26.0% identity in 100
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1365c"
/db_xref="EnsemblGenomes-Tr:CCP44123"
/db_xref="GOA:P9WGE3"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR003658"
/db_xref="InterPro:IPR036513"
/db_xref="UniProtKB/Swiss-Prot:P9WGE3"
/protein_id="CCP44123.1"
/translation="MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTW
QDLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAV
ARIIHACGYGDVLPVHPTTESALSAT"
gene 1538390..1539211
/locus_tag="Rv1366"
CDS 1538390..1539211
/codon_start=1
/transl_table=11
/locus_tag="Rv1366"
/product="Hypothetical protein"
/note="Rv1366, (MTCY02B10.30), len: 273 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1366"
/db_xref="EnsemblGenomes-Tr:CCP44124"
/db_xref="GOA:P9WLZ5"
/db_xref="InterPro:IPR007685"
/db_xref="UniProtKB/Swiss-Prot:P9WLZ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44124.1"
/translation="MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSY
AEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDI
AGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADL
AMHEAEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG"
gene 1539180..1539440
/locus_tag="Rv1366A"
CDS 1539180..1539440
/codon_start=1
/transl_table=11
/locus_tag="Rv1366A"
/product="Conserved protein"
/note="Rv1366A, len: 86 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv1366A"
/db_xref="EnsemblGenomes-Tr:CCP44125"
/db_xref="UniProtKB/TrEMBL:V5QQR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44125.1"
/translation="MRPSRQGEVGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKL
EAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR"
gene complement(1539512..1540645)
/locus_tag="Rv1367c"
CDS complement(1539512..1540645)
/codon_start=1
/transl_table=11
/locus_tag="Rv1367c"
/product="Conserved protein"
/note="Rv1367c, (MTCY02B12.01c,MTCY02B10.31c), len: 377
aa. Conserved protein. Some similarity to penicillin
binding proteins e.g. PBPE_BACSU|P32959 penicillin-binding
protein 4* (pbp 4*) from Bacillus subtilis (451 aa), FASTA
scores: E(): 6.9e-06, (23.6% identity in 373 aa overlap).
Similar to AL031107|SC5A7.06 hypothetical protein from
Streptomyces coelicolor (409 aa), FASTA scores: opt: 675,
E(): 0, (40.4% identity in 339 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1367c"
/db_xref="EnsemblGenomes-Tr:CCP44126"
/db_xref="GOA:P9WLZ3"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/Swiss-Prot:P9WLZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44126.1"
/translation="MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAA
AMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGL
AYGFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSR
IEDAPLYQIIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVT
PPSFCNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHS
FLGAPFWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILL
YLIQHCPDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL"
gene 1541020..1541805
/gene="lprF"
/locus_tag="Rv1368"
CDS 1541020..1541805
/codon_start=1
/transl_table=11
/gene="lprF"
/locus_tag="Rv1368"
/product="Probable conserved lipoprotein LprF"
/note="Rv1368, (MTCY02B12.02), len: 261 aa. Probable
lprF,conserved lipoprotein; similar to Mycobacterium
tuberculosis hypothetical lipoproteins e.g.
Rv1270c|Y08C_MYCTU|Q11049 hypothetical 26.4 kDa protein
cy50.12. (257 aa), FASTA scores: opt: 286, E():
5.3e-11,(26.3% identity in 270 aa overlap), also
Rv1411c|MTCY21B4.28c, (32.8% identity in 253 aa overlap)
and Rv2945c. Contains possible N-terminal signal sequence
and appropriately positioned prokaryotic lipoprotein lipid
attachment site (PS00013). Belongs to the LPPX/lprafg
family of lipoproteins."
/db_xref="EnsemblGenomes-Gn:Rv1368"
/db_xref="EnsemblGenomes-Tr:CCP44127"
/db_xref="GOA:P9WK47"
/db_xref="InterPro:IPR009830"
/db_xref="InterPro:IPR029046"
/db_xref="UniProtKB/Swiss-Prot:P9WK47"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44127.1"
/translation="MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPT
TASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQG
NGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDR
GLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIV
DTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG"
repeat_region 1541949..1541951
/note="3 bp direct repeat, CGG, at 3' end of IS6110 target
sequence"
mobile_element complement(1541952..1543306)
/mobile_element_type="insertion sequence:IS6110-2"
/note="IS6110-2, len: 1355 nt. Almost identical to
Insertion sequence IS986 element."
gene complement(1541994..>1542980)
/locus_tag="Rv1369c"
CDS complement(1541994..>1542980)
/codon_start=1
/transl_table=11
/locus_tag="Rv1369c"
/product="Probable transposase"
/note="Rv1369c, (MTCY02B12.03c), len: 328 aa. Probable
transposase subunit for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv1368c and Rv1369c, the
sequence UUUUAAAG (directly upstream of Rv1369c) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (+ 34
aa)."
/db_xref="EnsemblGenomes-Gn:Rv1369c"
/db_xref="EnsemblGenomes-Tr:CCP44128"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP44128.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
gene complement(1542929..1543255)
/locus_tag="Rv1370c"
CDS complement(1542929..1543255)
/codon_start=1
/transl_table=11
/locus_tag="Rv1370c"
/product="Putative transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv1370c, (MTCY02B12.04c), len: 108 aa. Putative
transposase for IS6110 (fragment), identical to many other
Mycobacterium tuberculosis IS6110 transposase subunits
e.g. Q50686|YIA4_MYCTU Insertion element IS6110
hypothetical 12.0 kDa protein (108 aa), fasta scores: E():
1.4e-43,(100.00% identity in 108 aa overlap). The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv1368c and
Rv1369c, the sequence UUUUAAAG (directly upstream of
Rv1369c) maybe responsible for such a frameshifting event
(see McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv1370c"
/db_xref="EnsemblGenomes-Tr:CCP44129"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP44129.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
repeat_region 1543307..1543309
/note="3 bp direct repeat, CGG, at 5' end of IS6110 target
sequence"
gene 1543359..1544828
/locus_tag="Rv1371"
CDS 1543359..1544828
/codon_start=1
/transl_table=11
/locus_tag="Rv1371"
/product="Probable conserved membrane protein"
/note="Rv1371, (MTCY02B12.05), len: 489 aa. Probable
membrane protein. Weak similarity to delta 5 fatty acid
desaturases e.g. AB022097|AB022097_1 Dictyostelium
discoideum (467 aa), FASTA score: opt: 173, E():
0.00052,(22.4% identity in 438 aa overlap); and Homo
sapiens."
/db_xref="EnsemblGenomes-Gn:Rv1371"
/db_xref="EnsemblGenomes-Tr:CCP44130"
/db_xref="GOA:P71799"
/db_xref="InterPro:IPR001199"
/db_xref="InterPro:IPR005804"
/db_xref="InterPro:IPR036400"
/db_xref="UniProtKB/TrEMBL:P71799"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44130.1"
/translation="MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWIS
KHPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPA
FLFKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVG
YFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNY
VALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMA
IRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQ
FVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAG
LSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLT
PSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV"
gene 1544825..1546006
/locus_tag="Rv1372"
CDS 1544825..1546006
/codon_start=1
/transl_table=11
/locus_tag="Rv1372"
/product="Conserved hypothetical protein"
/note="Rv1372, (MTCY02B12.06), len: 393 aa. Conserved
hypothetical protein, similar to several chalcone
synthases e.g. CHS2_GERHY|P48391 chalcone synthase 2 from
gerbra hybrid (402 aa), FASTA scores: opt: 511, E():
7e-26, (28.4% identity in 380 aa overlap). Also similar to
Mycobacterium tuberculosis hypothetical chalcone
synthases, Rv1665,Rv1660."
/db_xref="EnsemblGenomes-Gn:Rv1372"
/db_xref="EnsemblGenomes-Tr:CCP44131"
/db_xref="GOA:P9WPF1"
/db_xref="InterPro:IPR001099"
/db_xref="InterPro:IPR011141"
/db_xref="InterPro:IPR012328"
/db_xref="InterPro:IPR016039"
/db_xref="PDB:1TED"
/db_xref="PDB:1TEE"
/db_xref="UniProtKB/Swiss-Prot:P9WPF1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44131.1"
/translation="MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPR
RVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATI
RDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELG
LSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDV
VIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCE
LSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELA
AQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIR
R"
gene 1546012..1546992
/locus_tag="Rv1373"
CDS 1546012..1546992
/codon_start=1
/transl_table=11
/locus_tag="Rv1373"
/product="Glycolipid sulfotransferase"
/note="Rv1373, (MTCY02B12.07), len: 326 aa. Glycolipid
sulfotransferase (see citation below); slight similarity
to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen
sulfotransferase from Cavia porcellus (Guinea pig) (296
aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity
in 294 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1373"
/db_xref="EnsemblGenomes-Tr:CCP44132"
/db_xref="GOA:P9WGB9"
/db_xref="InterPro:IPR000863"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WGB9"
/protein_id="CCP44132.1"
/translation="MNSEHPMTDRVVYRSLMADNLRWDALQLRDGDIIISAPSKSGLT
WTQRLVSLLVFDGPDLPGPLSTVSPWLDQTIRPIEEVVATLDAQQHRRFIKTHTPLDG
LVLDDRVSYICVGRDPRDAAVSMLYQSANMNEDRMRILHEAVVPFHERIAPPFAELGH
ARSPTEEFRDWMEGPNQPPPGIGFTHLKGIGTLANILHQLGTVWVRRHLPNVALFHYA
DYQADLAGELLRPARVLGIAATRDRARDLAQYATLDAMRSRASEIAPNTTDGIWHSDE
RFFRRGGSGDWQQFFTEAEHLRYYHRINQLAPPDLLAWAHEGRRGYDPAN"
gene complement(1547072..1547530)
/locus_tag="Rv1374c"
CDS complement(1547072..1547530)
/codon_start=1
/transl_table=11
/locus_tag="Rv1374c"
/product="Hypothetical protein"
/note="Rv1374c, (MTCY02B12.08c), len: 152 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1374c"
/db_xref="EnsemblGenomes-Tr:CCP44133"
/db_xref="UniProtKB/TrEMBL:P71802"
/protein_id="CCP44133.1"
/translation="MVTSVADENVASRIASWGTGPAPDPRLDYAHAHLKGRRGRSPAR
PNAPIGARSFAVGRKICRVERFTLLEHGFVGHALHRVPCAGLVALVMSACSLAVCREV
GNYAQRRVGRFAFFEQTFVRHALTPRCSRTDSKTSYTQLNRICKFPPHWV"
gene 1547129..1547268
/gene="MTS1082"
ncRNA 1547129..1547268
/gene="MTS1082"
/product="Putative small regulatory RNA"
/note="MTS1082, putative small regulatory RNA (See Arnvig
et al., 2011), ends not mapped, ~150 bp band detected by
Northern blot."
/ncRNA_class="other"
gene 1547832..1549151
/locus_tag="Rv1375"
CDS 1547832..1549151
/codon_start=1
/transl_table=11
/locus_tag="Rv1375"
/product="Conserved hypothetical protein"
/note="Rv1375, (MTCY02B12.09), len: 439 aa. Conserved
hypothetical protein, similar to hypothetical proteins
from several organisms e.g. Q52871|U39409 Rhizobium
leguminosarum (420 aa), FASTA scores: E(): 2e-30, (34.4%
identity in 378 aa overlap). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1375"
/db_xref="EnsemblGenomes-Tr:CCP44134"
/db_xref="InterPro:IPR003776"
/db_xref="UniProtKB/Swiss-Prot:P9WF27"
/protein_id="CCP44134.1"
/translation="MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWP
SRVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITGVADVTWLDCLGIPTVQ
AVRPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYD
PAQLRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDT
TGLASGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDA
GDDVDLARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSRAITEAAQSRITA
ISGAREDLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATA
VANRSGTEPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE"
gene 1549148..1550641
/locus_tag="Rv1376"
CDS 1549148..1550641
/codon_start=1
/transl_table=11
/locus_tag="Rv1376"
/product="Conserved hypothetical protein"
/note="Rv1376, (MTCY02B12.10), len: 497 aa. Conserved
hypothetical protein, some similarity to hypothetical
proteins from several organisms e.g. Q52872|U39409
Rhizobium leguminosarum (247 aa), FASTA scores: E():
2.1e-12, (34.7% identity in 219 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1376"
/db_xref="EnsemblGenomes-Tr:CCP44135"
/db_xref="InterPro:IPR012924"
/db_xref="InterPro:IPR016845"
/db_xref="UniProtKB/TrEMBL:P71804"
/protein_id="CCP44135.1"
/translation="MTACGRIVVTAGPTISAADIRSVVPDAEVAPPIAFGQALSYDLR
SGDTLLIVDGLFFQQPSVRHKELLTLMADGVRVVGSSSMGALRAAELHPFGMEGYGWV
FESYRDGVLEADDEVGVVHGDADDGYPVFVDALVNMRHTLARAVATGVVCSELAERII
ETARATPFTMRTWARLLSEVGAPDQRGLAAQLRSLRVDVKHADALLALRQLGQRPRVE
PLRPGPPPTVWSRRWRQRWAPPTSVAASADHGESFVDVTDLEVLSFLSVSSVDYWAYR
PALQQVAAWYWTLKHPEQSGSVGERAARAVAEVASEGYGRALEFIAYRYALATGIIDE
TGFPEAVAAHWLTTEERHGLGNDPISISARVITRTLFVVRLLPAIDHFLDLLRKDSRL
PRWRAMAAHALCKRDDLARQKPHLNLGRPDPTQLKRLFGARWGTQVNRIELARRGLMT
EDAFYAAATPFAVAAVDDQLPRIEVGTLGPAPLSADVPERHFDFGSV"
gene complement(1550579..1551217)
/locus_tag="Rv1377c"
CDS complement(1550579..1551217)
/codon_start=1
/transl_table=11
/locus_tag="Rv1377c"
/product="Putative transferase"
/note="Rv1377c, (MTCY02B12.11c), len: 212 aa. Putative
transferase, similar to YQEM_BACSU|P54458 hypothetical
28.3 kDa protein from Bacillus subtilis (247 aa), FASTA
scores: opt: 221, E(): 7.6e-08, (30.6% identity in 144 aa
overlap); some similarity to methyltransferases, also
similar to Mycobacterium tuberculosis hypothetical
proteins Rv0560c,Rv3699, and Rv2675c (~ 39.1% identity in
197 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1377c"
/db_xref="EnsemblGenomes-Tr:CCP44136"
/db_xref="GOA:P71805"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:P71805"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44136.1"
/translation="MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGW
VHGDVLDIGCGLGDNAIYLARNGYQVTGLDISPTALTTAKRRASDAGVDVKFAVGDAT
KLTGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRATRPGATLLLSCFSNAMPPDEEW
PRSTVSEQTLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS"
gene complement(1551228..1552655)
/locus_tag="Rv1378c"
CDS complement(1551228..1552655)
/codon_start=1
/transl_table=11
/locus_tag="Rv1378c"
/product="Conserved hypothetical protein"
/note="Rv1378c, (MTCY02B12.12c), len: 475 aa. Conserved
hypothetical protein, similar to other Mycobacterium
tuberculosis hypothetical proteins e.g.
Rv3074|MTCY22D7.07C (424 aa), FASTA scores: E(): 0, (73.0%
identity in 429 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1378c"
/db_xref="EnsemblGenomes-Tr:CCP44137"
/db_xref="GOA:P71806"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:P71806"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44137.1"
/translation="MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAIL
EHMFDLVSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEADAG
VPARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALEVGRLSEWRATL
IVRESACLDVEDRRALDAELCADMSALDGMGDARIAAAARAIAYRLDAQAVVERAARA
ETERTVTIRPAPDTMTWVTALLPVARGVSVYAALKRAADTTFDDRTRGQVMADTLVER
VTGQPAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVADTRSR
ATLRRLYRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCDAPIRHRDHAQPH
HRGGPTTATNGLGSCERCNYVKEAPGWRVSTDTDETGRHTAEFTTPTGMYYHCTAPPL
PGPLEIDVSQVEARIGVALTHLHAA"
gene 1552654..1553235
/gene="pyrR"
/locus_tag="Rv1379"
CDS 1552654..1553235
/codon_start=1
/transl_table=11
/gene="pyrR"
/locus_tag="Rv1379"
/product="Probable pyrimidine operon regulatory protein
PyrR"
/note="Rv1379, (MTCY02B12.13), len: 193 aa. Probable
pyrR,pyrimidine operon regulatory protein, similar to
PYRR_BACCL|P41007 pyrimidine operon regulatory protein
from Bacillus caldolyticus (179 aa), FASTA scores: opt:
544,E(): 1.1e-30, (54.2% identity in 179 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1379"
/db_xref="EnsemblGenomes-Tr:CCP44138"
/db_xref="GOA:P9WHK3"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR023050"
/db_xref="InterPro:IPR029057"
/db_xref="PDB:1W30"
/db_xref="PDB:5IAO"
/db_xref="UniProtKB/Swiss-Prot:P9WHK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44138.1"
/translation="MGAAGDAAIGRESRELMSAADVGRTISRIAHQIIEKTALDDPVG
PDAPRVVLLGIPTRGVTLANRLAGNITEYSGIHVGHGALDITLYRDDLMIKPPRPLAS
TSIPAGGIDDALVILVDDVLYSGRSVRSALDALRDVGRPRAVQLAVLVDRGHRELPLR
ADYVGKNVPTSRSESVHVRLREHDGRDGVVISR"
gene 1553232..1554191
/gene="pyrB"
/locus_tag="Rv1380"
CDS 1553232..1554191
/codon_start=1
/transl_table=11
/gene="pyrB"
/locus_tag="Rv1380"
/product="Probable aspartate carbamoyltransferase PyrB
(ATCase) (aspartate transcarbamylase)"
/note="Rv1380, (MTCY02B12.14), len: 319 aa. Probable
pyrB,aspartate carbamoyltransferase, similar to many e.g.
PYRB_BACCL|P41008 aspartate carbamoyltransferase from
Bacillus caldolyticus (308 aa), FASTA scores, opt:
639,E(): 7.3e-36, (39.5% identity in 311 aa overlap).
Contains PS00097 Aspartate and ornithine
carbamoyltransferases signature. Belongs to the
ATCases/OTCases family."
/db_xref="EnsemblGenomes-Gn:Rv1380"
/db_xref="EnsemblGenomes-Tr:CCP44139"
/db_xref="GOA:P9WIT7"
/db_xref="InterPro:IPR002082"
/db_xref="InterPro:IPR006130"
/db_xref="InterPro:IPR006131"
/db_xref="InterPro:IPR006132"
/db_xref="InterPro:IPR036901"
/db_xref="UniProtKB/Swiss-Prot:P9WIT7"
/inference="protein motif:PROSITE:PS00097"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44139.1"
/translation="MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRG
RTVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGAD
ALIIRHPASGAAHLLAQWTGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEG
RRIVIVGDILHSRVARSNVMLLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELP
AADAVLMLRVQAERMNGGFFPSVREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEI
TSSVADSSQSAVLQQVSNGVQVRMAVLFHVLVGAQDAGKEGAA"
gene 1554188..1555480
/gene="pyrC"
/locus_tag="Rv1381"
CDS 1554188..1555480
/codon_start=1
/transl_table=11
/gene="pyrC"
/locus_tag="Rv1381"
/product="Probable dihydroorotase PyrC (DHOase)"
/note="Rv1381, (MTCY02B12.15), len: 430 aa. Probable
pyrC,dihydroorotase, similar to many e.g.
PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap).
Contains PS00483 Dihydroorotase signature 2. Belongs to
the DHOase family. subfamily 2."
/db_xref="EnsemblGenomes-Gn:Rv1381"
/db_xref="EnsemblGenomes-Tr:CCP44140"
/db_xref="GOA:P9WHL3"
/db_xref="InterPro:IPR002195"
/db_xref="InterPro:IPR004722"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR011059"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/Swiss-Prot:P9WHL3"
/inference="protein motif:PROSITE:PS00483"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44140.1"
/translation="MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDA
TGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVT
DHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLI
MRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDAL
LARDAGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRV
NPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVV
VQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGA
DLASRSANTPFESMSLPATVTATLLRGKVTARDGKIRA"
gene 1555477..1555974
/locus_tag="Rv1382"
CDS 1555477..1555974
/codon_start=1
/transl_table=11
/locus_tag="Rv1382"
/product="Probable export or membrane protein"
/note="Rv1382, (MTCY02B12.16), len: 165 aa. Possible
exported or membrane protein, hydrophobic domain at
N-terminus. Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1382"
/db_xref="EnsemblGenomes-Tr:CCP44141"
/db_xref="GOA:P71810"
/db_xref="UniProtKB/TrEMBL:P71810"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44141.1"
/translation="MNSGTLAGSLIFAAVLVMLIAVLARLMMRGWRRRSERQAELLGD
LPDVPEHVSSATVTTRGLYVGATLSPAWNERVTVGDLGYRSKAVLTRYPSGIMVERAR
AQPIWIPTESIAAIRMERGVAGKVVAGIGILAIRWRLPSGTEIDVGFRADNRDEYQEW
LEEPV"
gene 1555971..1557101
/gene="carA"
/locus_tag="Rv1383"
CDS 1555971..1557101
/codon_start=1
/transl_table=11
/gene="carA"
/locus_tag="Rv1383"
/product="Probable carbamoyl-phosphate synthase small
chain CarA (carbamoyl-phosphate synthetase glutamine
chain)"
/note="Rv1383, (MTCY02B12.17), len: 376 aa. Probable
carA,Carbamoyl-phosphate synthase small chain, similar to
many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate synthase
small chain from Escherichia coli (382 aa), FASTA scores:
opt: 796, E(): 0, (45.5% identity in 382 aa overlap).
Contains PS00442 Glutamine amidotransferases class-I
active site. The gatase domain belongs to type-1 glutamine
amidotransferases. subunit: composed of two chains; the
small (or glutamine) chain promotes the hydrolysis of
glutamine to ammonia, which is used by the large (or
ammonia) chain to synthesize carbamoyl phosphate."
/db_xref="EnsemblGenomes-Gn:Rv1383"
/db_xref="EnsemblGenomes-Tr:CCP44142"
/db_xref="GOA:P9WPK5"
/db_xref="InterPro:IPR002474"
/db_xref="InterPro:IPR006274"
/db_xref="InterPro:IPR017926"
/db_xref="InterPro:IPR029062"
/db_xref="InterPro:IPR035686"
/db_xref="InterPro:IPR036480"
/db_xref="UniProtKB/Swiss-Prot:P9WPK5"
/inference="protein motif:PROSITE:PS00442"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44142.1"
/translation="MSKAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMSGYQETLTD
PSYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDPSPRASNWRATGTLEDE
LIRQRIVGIAGIDTRAVVRHLRSRGSMKAGVFSDGALAEPADLIARVRAQQSMLGADL
AGEVSTAEPYVVEPDGPPGVSRFTVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQ
IAELNPHGVFLSNGPGDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYK
MVFGHRGINIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGVV
EGVKLVDGRAFSVQYHPEAAAGPHDAEYLFDQFVELMAGEGR"
gene 1557101..1560448
/gene="carB"
/locus_tag="Rv1384"
CDS 1557101..1560448
/codon_start=1
/transl_table=11
/gene="carB"
/locus_tag="Rv1384"
/product="Probable carbamoyl-phosphate synthase large
chain CarB (carbamoyl-phosphate synthetase ammonia chain)"
/note="Rv1384, (MTCY02B12.18-MTCY21B4.01), len: 1115 aa.
Probable carB, Carbamoyl-phosphate synthase large chain
,similar to many e.g. CARB_ECOLI|P00968 E. coli (1072
aa),FASTA scores: E(): 0, (52.3% identity in 1118 aa
overlap). Contains two PS00867 Carbamoyl-phosphate
synthase subdomain signature 2 and PS00866
Carbamoyl-phosphatesynthase subdomain signature 1.
subunit: composed of two chains; the small (or glutamine)
chain promotes the hydrolysis of glutamine to ammonia,
which is used by the large (or ammonia) chain to
synthesize carbamoyl phosphate."
/db_xref="EnsemblGenomes-Gn:Rv1384"
/db_xref="EnsemblGenomes-Tr:CCP44143"
/db_xref="GOA:P9WPK3"
/db_xref="InterPro:IPR005479"
/db_xref="InterPro:IPR005480"
/db_xref="InterPro:IPR005483"
/db_xref="InterPro:IPR006275"
/db_xref="InterPro:IPR011607"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR016185"
/db_xref="InterPro:IPR033937"
/db_xref="InterPro:IPR036897"
/db_xref="InterPro:IPR036914"
/db_xref="UniProtKB/Swiss-Prot:P9WPK3"
/inference="protein motif:PROSITE:PS00867"
/inference="protein motif:PROSITE:PS00866"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44143.1"
/translation="MPRRTDLHHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLQV
SLVNSNPATIMTDPEFADHTYVEPITPAFVERVIAQQAERGNKIDALLATLGGQTALN
TAVALYESGVLEKYGVELIGADFDAIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEV
RETVAELGLPVVVRPSFTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGW
KEFELELMRDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAI
LREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIG
YTLDEIVNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLG
RNFVEALGKVMRSLETTRAGFWTAPDPDGGIEEALTRLRTPAEGRLYDIELALRLGAT
VERVAEASGVDPWFIAQINELVNLRNELVAAPVLNAELLRRAKHSGLSDHQIASLRPE
LAGEAGVRSLRVRLGIHPVYKTVDTCAAEFEAQTPYHYSSYELDPAAETEVAPQTERP
KVLILGSGPNRIGQGIEFDYSCVHAATTLSQAGFETVMVNCNPETVSTDYDTADRLYF
EPLTFEDVLEVYHAEMESGSGGPGVAGVIVQLGGQTPLGLAHRLADAGVPIVGTPPEA
IDLAEDRGAFGDLLSAAGLPAPKYGTATTFAQARRIAEEIGYPVLVRPSYVLGGRGME
IVYDEETLQGYITRATQLSPEHPVLVDRFLEDAVEIDVDALCDGAEVYIGGIMEHIEE
AGIHSGDSACALPPVTLGRSDIAKVRKATEAIAHGIGVVGLLNVQYALKDDVLYVLEA
NPRASRTVPFVSKATAVPLAKACARIMLGATIAQLRAEGLLAVTGDGAHAARNAPIAV
KEAVLPFHRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKSQTAAYGSLPAQG
TVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDDVRKHFEPAQPG
RPTMSAVDAIRAGEVNMVINTPYGNSGPRIDGYEIRSAAVAGNIPCITTVQGASAAVQ
GIEAGIRGDIGVRSLQELHRVIGGVER"
gene 1560445..1561269
/gene="pyrF"
/locus_tag="Rv1385"
CDS 1560445..1561269
/codon_start=1
/transl_table=11
/gene="pyrF"
/locus_tag="Rv1385"
/product="Probable orotidine 5'-phosphate decarboxylase
PyrF (OMP decarboxylase) (ompdecase)"
/note="Rv1385, (MTCY21B4.02), len: 274 aa. Probable
pyrF,orotidine 5'-phosphate decarboxylase, identical to
DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains
PS00156 Orotidine 5'-phosphate decarboxylase active site.
Belongs to the OMP decarboxylase family."
/db_xref="EnsemblGenomes-Gn:Rv1385"
/db_xref="EnsemblGenomes-Tr:CCP44144"
/db_xref="GOA:P9WIU3"
/db_xref="InterPro:IPR001754"
/db_xref="InterPro:IPR011060"
/db_xref="InterPro:IPR011995"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR018089"
/db_xref="UniProtKB/Swiss-Prot:P9WIU3"
/inference="protein motif:PROSITE:PS00156"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44144.1"
/translation="MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAF
CDICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGAT
MSAYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAV
QNAAADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGV
GVQGGRPEALGGLGGAASSQLLPAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV"
gene 1561464..1561772
/gene="PE15"
/locus_tag="Rv1386"
CDS 1561464..1561772
/codon_start=1
/transl_table=11
/gene="PE15"
/locus_tag="Rv1386"
/product="PE family protein PE15"
/note="Rv1386, (MTCY21B4.03), len: 102 aa. PE15, Member of
Mycobacterium tuberculosis PE family (see Brennan & Delogu
2002), similar to many e.g. G913039 ORF 3' of PGRS tandem
repeat (polymorphic GC-rich sequence) (100 aa), FASTA
scores: opt: 149, E(): 0.0013, (31.5% identity in 92 aa
overlap); also similar to Q49943|U1756A (99 aa) (34.7%
identity in 95 aa overlap) and G466937|U1620K (100 aa)
(36.2% identity in 69 aa overlap). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004). Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1386"
/db_xref="EnsemblGenomes-Tr:CCP44145"
/db_xref="GOA:P9WIH1"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIH1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44145.1"
/translation="MTLRVVPESLAGASAAIEAVTARLAAAHAAAAPFIAAVIPPGSD
SVSVCNAVEFSVHGSQHVAMAAQGVEELGRSGVGVAESGASYAARDALAAASYLSGGL
"
gene 1561769..1563388
/gene="PPE20"
/locus_tag="Rv1387"
CDS 1561769..1563388
/codon_start=1
/transl_table=11
/gene="PPE20"
/locus_tag="Rv1387"
/product="PPE family protein PPE20"
/note="Rv1387, (MTCY21B4.04), len: 539 aa. PPE20, Member
of Mycobacterium tuberculosis PPE family of proteins,
similar to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9
kd protein cy251.15 (463 aa), FASTA scores: E(): 4.2e-26,
(37.7% identity in 531 aa overlap); similar also to
MTCY274.23c (37.5% identity in 168 aa overlap). Contains
PS00343 Gram-positive cocci surface proteins 'anchoring'
hexapeptide. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1387"
/db_xref="EnsemblGenomes-Tr:CCP44146"
/db_xref="GOA:P9WI23"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI23"
/inference="protein motif:PROSITE:PS00343"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44146.1"
/translation="MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAA
SEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMAAQQHVVIEAYTAA
VELMPTQVELAANQIKLAVLVATNFFGINTIPIAINEAEYVEMWVRAATTMATYSTVS
RSALSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMIDNFFAEILR
GVSAGRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGA
FQFLLYVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPS
AAIPAVVPELTPVAAAPPMLAVAGVGPAVAAPGMLPASAPAPAAAAGATAAGPTPPAT
GFGGFPPYLVGGGGPGIGFGSGQSAHAKAAASDSAAAESAAQASARAQARAARRGRSA
AKARGHRDEFVTMDMGFDAAAPAPEHQPGARASDCGAGPIGFAGTVRKEAVVKAAGLT
TLAGDDFGGGPTMPMMPGTWTHDQGVFDEHR"
gene 1563694..1564266
/gene="mihF"
/locus_tag="Rv1388"
CDS 1563694..1564266
/codon_start=1
/transl_table=11
/gene="mihF"
/locus_tag="Rv1388"
/product="Putative integration host factor MihF"
/note="Rv1388, (MTCY21B4.05), len: 190 aa. Putative
mihF,integration host factor. Almost identical to, but
longer than, P96802|U75344 Mycobacterium smegmatis
integration host factor (mIHF) for mycobacteriophage L5
(105 aa), FASTA scores: E(): 0, (96.1% identity in 102 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1388"
/db_xref="EnsemblGenomes-Tr:CCP44147"
/db_xref="GOA:P71658"
/db_xref="UniProtKB/TrEMBL:P71658"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44147.1"
/translation="MLGNTIHVPCQPCRHGHGAPSRGLRGRPADRWPVARATPTLHVC
PQNQGVGLDFVRKPEYGRLRWPAYPAGTNNDRLISMRDGGIVALPQLTDEQRAAALEK
AAAARRARAELKDRLKRGGTNLTQVLKDAESDEVLGKMKVSALLEALPKVGKVKAQEI
MTELEIAPTRRLRGLGDRQRKALLEKFGSA"
gene 1564401..1565027
/gene="gmk"
/locus_tag="Rv1389"
CDS 1564401..1565027
/codon_start=1
/transl_table=11
/gene="gmk"
/locus_tag="Rv1389"
/product="Probable guanylate kinase Gmk"
/note="Rv1389, (MTCY21B4.06), len: 208 aa. Probable
gmk,guanylate kinase, similar to e.g. KGUA_ECOLI|P24234
guanylate kinase from Escherichia coli (207 aa), FASTA
scores: opt: 424, E(): 6.6e-20, (35.9% identity in 184 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop), PS00856 Guanylate kinase signature. Belongs to
the guanylate kinase family."
/db_xref="EnsemblGenomes-Gn:Rv1389"
/db_xref="EnsemblGenomes-Tr:CCP44148"
/db_xref="GOA:P9WKE9"
/db_xref="InterPro:IPR008144"
/db_xref="InterPro:IPR008145"
/db_xref="InterPro:IPR017665"
/db_xref="InterPro:IPR020590"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:1S4Q"
/db_xref="PDB:1Z8F"
/db_xref="PDB:1ZNW"
/db_xref="PDB:1ZNX"
/db_xref="PDB:1ZNY"
/db_xref="PDB:1ZNZ"
/db_xref="UniProtKB/Swiss-Prot:P9WKE9"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00856"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44148.1"
/translation="MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRER
IPNLHFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTL
AQPVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETA
DVIQRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLVGTAPGSP"
gene 1565093..1565425
/gene="rpoZ"
/locus_tag="Rv1390"
CDS 1565093..1565425
/codon_start=1
/transl_table=11
/gene="rpoZ"
/locus_tag="Rv1390"
/product="Probable DNA-directed RNA polymerase (omega
chain) RpoZ (transcriptase omega chain) (RNA polymerase
omega subunit)"
/note="Rv1390, (MTCY21B4.07), len: 110 aa. Probable
rpoZ,DNA-directed RNA polymerase omega chain. Belongs to
the RNA polymerase omega chain family."
/db_xref="EnsemblGenomes-Gn:Rv1390"
/db_xref="EnsemblGenomes-Tr:CCP44149"
/db_xref="GOA:P9WGY5"
/db_xref="InterPro:IPR003716"
/db_xref="InterPro:IPR006110"
/db_xref="InterPro:IPR012293"
/db_xref="InterPro:IPR036161"
/db_xref="PDB:5UH5"
/db_xref="PDB:5UH6"
/db_xref="PDB:5UH8"
/db_xref="PDB:5UH9"
/db_xref="PDB:5UHA"
/db_xref="PDB:5UHB"
/db_xref="PDB:5UHC"
/db_xref="PDB:5UHD"
/db_xref="PDB:5UHE"
/db_xref="PDB:5UHF"
/db_xref="PDB:5UHG"
/db_xref="PDB:5ZX2"
/db_xref="PDB:5ZX3"
/db_xref="PDB:6BZO"
/db_xref="PDB:6C04"
/db_xref="PDB:6C05"
/db_xref="PDB:6C06"
/db_xref="PDB:6DV9"
/db_xref="PDB:6DVB"
/db_xref="PDB:6DVC"
/db_xref="PDB:6DVD"
/db_xref="PDB:6DVE"
/db_xref="PDB:6EDT"
/db_xref="PDB:6EE8"
/db_xref="PDB:6EEC"
/db_xref="PDB:6FBV"
/db_xref="PDB:6JCX"
/db_xref="PDB:6JCY"
/db_xref="PDB:6M7J"
/db_xref="UniProtKB/Swiss-Prot:P9WGY5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44149.1"
/translation="MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELL
DRVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHAD
LLEHTEGE"
gene 1565441..1566697
/gene="dfp"
/locus_tag="Rv1391"
CDS 1565441..1566697
/codon_start=1
/transl_table=11
/gene="dfp"
/locus_tag="Rv1391"
/product="Probable DNA/pantothenate metabolism
flavoprotein homolog Dfp"
/note="Rv1391, (MTCY21B4.08), len: 418 aa. Probable
dfp,DNA/pantothenate metabolism flavoprotein homolog,
similar to many e.g. DFP_ECOLI|P24285 Escherichia coli
(430 aa),FASTA scores: opt: 763, E(): 0, (40.2% identity
in 408 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1391"
/db_xref="EnsemblGenomes-Tr:CCP44150"
/db_xref="GOA:P9WNZ1"
/db_xref="InterPro:IPR003382"
/db_xref="InterPro:IPR005252"
/db_xref="InterPro:IPR007085"
/db_xref="InterPro:IPR035929"
/db_xref="InterPro:IPR036551"
/db_xref="UniProtKB/Swiss-Prot:P9WNZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44150.1"
/translation="MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTE
SALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAG
RADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGA
DSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSS
GKQGYAVARVAAQRGADVTLIAGHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADV
LVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIV
GFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESA
LQHGSKTLMASRIVDAIVTFLAGCSS"
gene 1566825..1568036
/gene="metK"
/locus_tag="Rv1392"
CDS 1566825..1568036
/codon_start=1
/transl_table=11
/gene="metK"
/locus_tag="Rv1392"
/product="Probable S-adenosylmethionine synthetase MetK
(mat) (AdoMet synthetase) (methionine
adenosyltransferase)"
/note="Rv1392, (MTCY21B4.09), len: 403 aa. Probable
metK,S-adenosylmethionine synthetase, similar to many e.g.
METK_STAAU|P50307 Staphylococcus aureus (397 aa), FASTA
scores: opt: 1484, E(): 0, (58.0% identity in 400 aa
overlap). Contains PS00376 S-adenosylmethionine synthetase
signature 1, PS00377 S-adenosylmethionine synthetase
signature 2. Belongs to the adomet synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv1392"
/db_xref="EnsemblGenomes-Tr:CCP44151"
/db_xref="GOA:P9WGV1"
/db_xref="InterPro:IPR002133"
/db_xref="InterPro:IPR022628"
/db_xref="InterPro:IPR022629"
/db_xref="InterPro:IPR022630"
/db_xref="InterPro:IPR022631"
/db_xref="InterPro:IPR022636"
/db_xref="PDB:3TDE"
/db_xref="UniProtKB/Swiss-Prot:P9WGV1"
/inference="protein motif:PROSITE:PS00376"
/inference="protein motif:PROSITE:PS00377"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44151.1"
/translation="MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAV
ETLVTTGQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIG
AQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRL
SRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPD
IREKVLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWA
RHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVE
TFGTETEDPVKIEKAIGEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQ
LDKVDDLKRAI"
gene complement(1568109..1569587)
/locus_tag="Rv1393c"
CDS complement(1568109..1569587)
/codon_start=1
/transl_table=11
/locus_tag="Rv1393c"
/product="Probable monoxygenase"
/note="Rv1393c, (MTCY21B4.10c), len: 492 aa. Probable
monooxygenase, similar to others e.g. CYMO_ACISP|P12015
cyclohexanone monooxygenase from Acinetobacter sp. (542
aa), FASTA scores: E(): 0, (33.0% identity in 473 aa
overlap); also to Rv3083|MTCY31.20|E241788 hypothetical
55.0 kDa protein from Mycobacterium tuberculosis (495 aa)
(36.3% identity in 490 aa overlap); and Rv0565c,
Rv3854c,Rv3049c, Rv0892."
/db_xref="EnsemblGenomes-Gn:Rv1393c"
/db_xref="EnsemblGenomes-Tr:CCP44152"
/db_xref="GOA:P71662"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:P71662"
/protein_id="CCP44152.1"
/translation="MMPDYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTW
HWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNT
KVLAAEFDDEHSLWRVQTDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTA
RWDHTQDLTGKRVGIIGTGASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFDVPLPTAV
RWAMRIPGGKAVHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHDPVV
REQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHEIDVL
VLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGYPNFFTVFGPYG
YVGSSYFALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQD
SCRLANSYYFDKNGDVPLRPTTTVEAYWRSRRFDLGDYRISS"
gene complement(1569584..1570969)
/gene="cyp132"
/locus_tag="Rv1394c"
CDS complement(1569584..1570969)
/codon_start=1
/transl_table=11
/gene="cyp132"
/locus_tag="Rv1394c"
/product="Probable cytochrome P450 132 Cyp132"
/note="Rv1394c, (MT1439, MTCY21B4.11c), len: 461 aa.
Probable cyp132, cytochrome P450 132. Some similarity to
others e.g. CP4B_HUMAN|P13584 human cytochrome p450 (511
aa), FASTA scores: opt: 486, E(): 7.4e-21, (28.6% identity
in 423 aa overlap); etc. Contains PS00086 Cytochrome P450
cysteine heme-iron ligand signature. May belong to the
cytochrome P450 family. Experimentally shown that the
expression of cyp132 is induced by the transcriptional
regulatory protein Rv1395 (Recchi et al., 2003)."
/db_xref="EnsemblGenomes-Gn:Rv1394c"
/db_xref="EnsemblGenomes-Tr:CCP44153"
/db_xref="GOA:P9WPN3"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002401"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPN3"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP44153.1"
/translation="MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGS
DITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWA
RHRGALNSTFARRHLRGLVGLMIDPIADVTAARVPGAQFDMHQSMVETTLRVVANALF
SQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLRE
MQEITLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGH
ETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRY
FSSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPT
DRPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRP
KHGVHVIGRRR"
gene 1571047..1572081
/locus_tag="Rv1395"
CDS 1571047..1572081
/codon_start=1
/transl_table=11
/locus_tag="Rv1395"
/product="Transcriptional regulatory protein"
/note="Rv1395, (MTCY21B4.12), len: 344 aa. Transcriptional
regulatory protein (see citation below), similar to many
e.g. URER_PROMI|Q02458 urease operon transcriptional
activator from Proteus mirabilis (293 aa), FASTA scores:
E():1.5e-08, (41.7% identity in 84 aa overlap);
YHIX_ECOLI|P37639 hypothetical transcriptional regulatory
protein from Escherichia coli (274 aa), FASTA scores: opt:
238, E(): 3.5e-09, (27.3% identity in 249 aa overlap); and
G296916|X68281 possible virulence-regulating protein from
Mycobacterium tuberculosis (339 aa), FASTA scores: opt:
228, E(): 1.9e-08, (27.0% identity in 278 aa overlap).
Helix turn helix motif present, aa 261-282 (+4.68 SD).
Belongs to the AraC/XylS family of transcriptional
regulators. 3' part corrected since first submission (-14
aa). Experimentally shown to induce the expression of the
cytochrome P450 gene (Rv1394c) and represses its own
transcription."
/db_xref="EnsemblGenomes-Gn:Rv1395"
/db_xref="EnsemblGenomes-Tr:CCP44154"
/db_xref="GOA:P9WMJ1"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR018060"
/db_xref="InterPro:IPR020449"
/db_xref="InterPro:IPR032687"
/db_xref="UniProtKB/Swiss-Prot:P9WMJ1"
/protein_id="CCP44154.1"
/translation="MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPAD
LDDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALTHFGLFGFAVMSCGTLRE
LLTIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRGFFIERDIAGIIATTTS
FALPLAAKYADQVSAELAVDAELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQ
ADRHTLEMCIAQCDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTL
RRRLAEEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYG
VAPSEYSRRG"
gene complement(1572127..1573857)
/gene="PE_PGRS25"
/locus_tag="Rv1396c"
CDS complement(1572127..1573857)
/codon_start=1
/transl_table=11
/gene="PE_PGRS25"
/locus_tag="Rv1396c"
/product="PE-PGRS family protein PE_PGRS25"
/note="Rv1396c, (MTCY21B4.13c), len: 576 aa.
PE_PGRS25,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002),strong similarity to many e.g. glycine rich
protein MTCY130.10C|E245019 (603 aa), FASTA scores: opt:
1945, E(): 0, (57.5% identity in 619 aa overlap). Contains
PS00017 ATP/GTP-binding site motif A, similar to other
PGRS-type sequences. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv1396c"
/db_xref="EnsemblGenomes-Tr:CCP44155"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:P71664"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP44155.1"
/translation="MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGA
DEVSAAVAALFSGHAQTYQALRTQAAAFHQQIVQTLTSTAGAYASAEAANVEQQLLGA
INAPTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNGGNGGSGATGQAGGAGGAAGL
IGHGGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAGGAGGAAGL
WGSGGSGGTGGQGGVGGGKSGDGGTGGIGGAGGGGGWLHGDGGAGGHGGQGGTGVSSG
GNGGAGGTGGDGRGLSGSGGAGGRGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAG
GNGGQGAISGAGGAGGNAWLIGDGGAGGNGGDIRGQGGGAGGAGGAGGQLIGNGGTGG
AGGTVTSPNGLGGAGGAGGSAGLIGHGGTGGAGGHSAQGPDGNGGIGGAGGAGGNGGQ
LYGTGGTGGTGGKGGDGFGVFGKGGAGGTGGRGGAAGLIGDAGTGGTGGKGGTAGEDG
TGGNGGTGGNGGAAVLIGNGGGGGAGGNGGAGNDGTPGNGGGGGVGGTGGTLFGQPGQ
PGPPGQPGPA"
gene complement(1574112..1574513)
/gene="vapC10"
/locus_tag="Rv1397c"
CDS complement(1574112..1574513)
/codon_start=1
/transl_table=11
/gene="vapC10"
/locus_tag="Rv1397c"
/product="Possible toxin VapC10"
/note="Rv1397c, (MTCY21B4.14c), len: 133 aa. Possible
vapC10, toxin, part of toxin-antitoxin (TA) operon with
Rv1398c, contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Conserved hypothetical
protein,similar to Mycobacterium tuberculosis protein
MTCY159.08C|Rv2548 (125 aa), FASTA scores: E():
2.3e-14,(42.4% identity in 125 aa overlap). This region is
a possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1397c"
/db_xref="EnsemblGenomes-Tr:CCP44156"
/db_xref="GOA:P9WFA7"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44156.1"
/translation="MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIG
GMRTAERREVWRLLASFRVQPATEVIARRAGDMMRRYRRSHNRIGLGDYLIAATADVQ
DLQLATLNVWHFPMFEQLKPPFAVPGHRPRA"
gene complement(1574510..1574767)
/gene="vapB10"
/locus_tag="Rv1398c"
CDS complement(1574510..1574767)
/codon_start=1
/transl_table=11
/gene="vapB10"
/locus_tag="Rv1398c"
/product="Possible antitoxin VapB10"
/note="Rv1398c, (MTCY21B4.15c), len: 85 aa. Possible
vapB10, antitoxin, part of toxin-antitoxin (TA) operon
with Rv1397c (See Arcus et al., 2005; Pandey and Gerdes,
2005). Similar to others in Mycobacterium tuberculosis
e.g. Rv2547|MTCY159.09C (85 aa), FASTA scores: E():
0.0035,(37.1% identity in 62 aa overlap); Rv0581, Rv2871,
Rv1241,etc. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1398c"
/db_xref="EnsemblGenomes-Tr:CCP44157"
/db_xref="GOA:P9WLZ1"
/db_xref="InterPro:IPR002145"
/db_xref="InterPro:IPR010985"
/db_xref="InterPro:IPR013321"
/db_xref="UniProtKB/Swiss-Prot:P9WLZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44157.1"
/translation="MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGD
DLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQVWRATS"
gene complement(1574850..1575809)
/gene="nlhH"
/locus_tag="Rv1399c"
CDS complement(1574850..1575809)
/codon_start=1
/transl_table=11
/gene="nlhH"
/locus_tag="Rv1399c"
/product="Probable non lipolytic carboxylesterase NlhH"
/note="Rv1399c, (MTCY21B4.16c), len: 319 aa. Possible
nlhH,non lipolytic carboxylesterase, most similar to
G695278 lipase like enzyme from Ralstonia eutropha (364
aa), FASTA scores: opt: 648, E(): 4.4e-34, (37.3% identity
in 327 aa ov erlap), similar to Mycobacterium tuberculosis
hypothetical lipases e.g. Rv2284, Rv2485c, Rv1426c, etc.
Previously known as lipH."
/db_xref="EnsemblGenomes-Gn:Rv1399c"
/db_xref="EnsemblGenomes-Tr:CCP44158"
/db_xref="GOA:P9WK87"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WK87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44158.1"
/translation="MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKT
PPELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDP
VARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAG
DSAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDA
FLAWYVPGLDISDHTMLPTTLAPGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAA
GVSVELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA"
gene complement(1575834..1576796)
/gene="lipI"
/locus_tag="Rv1400c"
CDS complement(1575834..1576796)
/codon_start=1
/transl_table=11
/gene="lipI"
/locus_tag="Rv1400c"
/product="Probable lipase LipH"
/note="Rv1400c, (MTCY21B4.17c), len: 320 aa. Possible
lipI,lipase, most similar to G695278 lipase like enzyme
(364 aa), FASTA sscores: opt: 611, E(): 3.5e-30, (36.6%
identity in 352 aa overlap); similar to M. tuberculosis
hypothetical lipases e.g. Rv1399c|MTCY21B4.16c (58.1%
identical in 315 aa overlap); Rv1426c, Rv2284, etc."
/db_xref="EnsemblGenomes-Gn:Rv1400c"
/db_xref="EnsemblGenomes-Tr:CCP44159"
/db_xref="GOA:P71668"
/db_xref="InterPro:IPR002168"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR033140"
/db_xref="UniProtKB/TrEMBL:P71668"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44159.1"
/translation="MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRD
LPRQPVHPELRVVDLAIDGPAGPIGTRIYWPPTCPDQAEAPVVLYFHGGGFVMGDLDT
HDGTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIA
VAGDSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPILDVKA
IAAFSRWYAGEIDLHNPPAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAA
AGVPVEVHNAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG"
gene 1576930..1577532
/locus_tag="Rv1401"
CDS 1576930..1577532
/codon_start=1
/transl_table=11
/locus_tag="Rv1401"
/product="Possible membrane protein"
/note="Rv1401, (MTCY21B4.18), len: 200 aa. Possible
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1401"
/db_xref="EnsemblGenomes-Tr:CCP44160"
/db_xref="GOA:P9WG51"
/db_xref="InterPro:IPR012506"
/db_xref="UniProtKB/Swiss-Prot:P9WG51"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44160.1"
/translation="MLQPAFKASMAVLLAAAAVAHPIGRERRWLVPALLLSATGDWLL
AIPWWTWAFVFGLGAFLLAHLCFIGALLPLARQAAPSRGRVAAVVAMCVASAGLLVWF
WPHLGKDNLTIPVTVYIVALSAMVCTALLARLPTIWTAVGAVCFAASDSMIGIGRFIL
GNEALAVPIWWSYAAAEILITAGFFFGREVPDNAAAPTDS"
gene 1577613..1579580
/gene="priA"
/locus_tag="Rv1402"
CDS 1577613..1579580
/codon_start=1
/transl_table=11
/gene="priA"
/locus_tag="Rv1402"
/product="Putative primosomal protein N' PriA (replication
factor Y)"
/note="Rv1402, (MTCY21B4.19), len: 655 aa. Putative
priA,primosomal protein N'. Similar to e.g.
PRIA_ECOLI|P17888 primosomal protein N' (replication
factor Y) (732 aa),FASTA scores, opt: 386, E(): 1.3e-16,
(27.6% identity in 711 aa overlap). Compared to other
bacterial priA, it has a very divergent helicase domain.
Belongs to the helicase family. PRIA subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1402"
/db_xref="EnsemblGenomes-Tr:CCP44161"
/db_xref="GOA:P9WMQ9"
/db_xref="InterPro:IPR005259"
/db_xref="InterPro:IPR041222"
/db_xref="InterPro:IPR042115"
/db_xref="UniProtKB/Swiss-Prot:P9WMQ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44161.1"
/translation="MLSVPHLDRDFDYLVPAEHSDDAQPGVRVRVRFHGRLVDGFVLE
RRSDSDHHGKLGWLDRVVSPEPVLTTEIRRLVDAVAARYAGTRQDVLRLAVPARHARV
EREITTAPGRPVVAPVDPSGWAAYGRGRQFLAALADSRAARAVWQALPGELWADRFAE
AAAQTVRAGRTVLAIVPDQRDLDTLWQAATALVDEHSVVALSAGLGPEARYRRWLAAL
RGSARLVIGTRSAVFAPLSELGLVMVWADADDSLAEPRAPYPHAREVAMLRAHQARCA
ALIGGYARTAEAHALVRSGWAHDVVAPRPEVRARSPRVVALDDSGYDDARDPAARTAR
LPSIALRAARSALQSGAPVLVQVPRRGYIPSLACGRCRAIARCRSCTGPLSLQGAGSP
GAVCRWCGRVDPTLRCVRCGSDVVRAVVVGARRTAEELGRAFPGTAVITSAGDTLVPQ
LDAGPALVVATPGAEPRAPGGYGAALLLDSWALLGRQDLRAAEDALWRWMTAAALVRP
RGAGGVVTVVAESSIPTVQSLIRWDPVGHAEAELAARTEVGLPPSVHIAALDGPAGTV
TALLEAARLPDPDRLQADLLGPVDLPPGVRRPAGIPADAPVIRMLLRVCREQGLELAA
SLRRGIGVLSARQTRQTRSLVRVQIDPLHIG"
gene complement(1579598..1580422)
/locus_tag="Rv1403c"
CDS complement(1579598..1580422)
/codon_start=1
/transl_table=11
/locus_tag="Rv1403c"
/product="Putative methyltransferase"
/note="Rv1403c, (MTCY21B4.20c), len: 274 aa. Putative
methyltransferase, similar to PMTA_RHOSH|Q05197
phosphatidylethanolamine m-methyltransferase (203
aa),FASTA scores: opt: 217, E(): 1.1e-07, (37.1% identity
in 105 aa overlap); similar to Rv1405c|MTCY21B4.22c (59.3%
identity in 273 aa overlap) and to Rv1523, Rv2952, etc."
/db_xref="EnsemblGenomes-Gn:Rv1403c"
/db_xref="EnsemblGenomes-Tr:CCP44162"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/Swiss-Prot:P9WLY9"
/protein_id="CCP44162.1"
/translation="MTVYTPTSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVST
SGIRRGDRVLDVAAGSGNVSIPAAMAGAHVTASDLTPELLRRAQARAAAAGLELGWRE
ANAEALPFSAGEFDAVLSTIGVMFAPRHQRTADELARVCRRGGKISTLNWTPEGFYGK
LLSTIRPYRPTLPAGAPHEVWWGSEDYVSGLFRDHVSDIRTRRGSLTVDRFGCPDECR
DYFKNFYGPAINAYRSIADSPECVATLDAEITELCREYLCDGVMQWEYLIFTARKC"
gene 1580591..1581073
/locus_tag="Rv1404"
CDS 1580591..1581073
/codon_start=1
/transl_table=11
/locus_tag="Rv1404"
/product="Probable transcriptional regulatory protein"
/note="Rv1404, (MTCY21B4.21), len: 160 aa. Probable
transcriptional regulatory protein, some similarity to
MARR_ECOLI|P27245 multiple antibiotic resistance protein
from Escherichia coli (125 aa), FASTA scores: opt:
136,E(): 0.004, (35.1% identity in 74 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1404"
/db_xref="EnsemblGenomes-Tr:CCP44163"
/db_xref="GOA:P71672"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR023187"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:2NYX"
/db_xref="UniProtKB/TrEMBL:P71672"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44163.1"
/translation="MMPTEYPATAEESVDVITDALLTASRLLVAISAHSIAQVDENIT
IPQFRTLVILSNHGPINLATLATLLGVQPSATGRMVDRLVGAELIDRLPHPTSRRELL
AALTKRGRDVVRQVTEHRRTEIARIVEQMAPAERHGLVRALTAFTEAGGEPDARYEIE
"
gene complement(1581145..1581969)
/locus_tag="Rv1405c"
CDS complement(1581145..1581969)
/codon_start=1
/transl_table=11
/locus_tag="Rv1405c"
/product="Putative methyltransferase"
/note="Rv1405c, (MTCY21B4.22c), len: 274 aa. Putative
methyltransferase, most similar to PMTA_RHOSH|Q05197
phosphatidylethanolamine m-methyltransferase (203
aa),FASTA scores: opt: 219, E(): 2.6e-07, (29.9% identity
in 144 aa overlap); similar to Rv1403c|MTCY21B4.20c (59.3%
identity in 273 aa overlap), Rv1523, Rv2952, etc."
/db_xref="EnsemblGenomes-Gn:Rv1405c"
/db_xref="EnsemblGenomes-Tr:CCP44164"
/db_xref="GOA:P9WLY7"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WLY7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44164.1"
/translation="MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAA
AGIGPGVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQQGLTLQYQE
ANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISWTCEGFFGR
MLATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLKTARGLLEVKRFDTAQAVH
DYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDGVMEWEYLLLTAEKR"
gene 1582166..1583104
/gene="fmt"
/locus_tag="Rv1406"
CDS 1582166..1583104
/codon_start=1
/transl_table=11
/gene="fmt"
/locus_tag="Rv1406"
/product="Probable methionyl-tRNA formyltransferase Fmt"
/note="Rv1406, (MTCY21B4.23), len: 312 aa. Probable
fmt,methionyl-tRNA formyltransferase, similar to many e.g.
FMT_ECOLI|P23882 Escherichia coli (314 aa), FASTA scores:
opt: 616, E(): 6.7e-31, (39.3% identity in 303 aa
overlap). Belongs to the FMT family."
/db_xref="EnsemblGenomes-Gn:Rv1406"
/db_xref="EnsemblGenomes-Tr:CCP44165"
/db_xref="GOA:P9WND3"
/db_xref="InterPro:IPR002376"
/db_xref="InterPro:IPR005793"
/db_xref="InterPro:IPR005794"
/db_xref="InterPro:IPR011034"
/db_xref="InterPro:IPR036477"
/db_xref="InterPro:IPR037022"
/db_xref="InterPro:IPR041711"
/db_xref="UniProtKB/Swiss-Prot:P9WND3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44165.1"
/translation="MRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKP
QPSPVAREAAERGIPVLRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPH
GWVNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTD
TAGDLLKRLAVSGAALLSTTLDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPA
AVVERRIRAVTPNPGAWTLIGDLRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGT
GSEPVRLGQIQPPGKKLMNAADWARGARLDLAARAT"
gene 1583101..1584474
/gene="fmu"
/locus_tag="Rv1407"
CDS 1583101..1584474
/codon_start=1
/transl_table=11
/gene="fmu"
/locus_tag="Rv1407"
/product="Probable Fmu protein (sun protein)"
/note="Rv1407, (MTCY21B4.24), len: 457 aa. Probable fmu
protein, similar to SUN_ECOLI|P36929 sun protein (fmu
protein) from Escherichia coli (429 aa), FASTA scores:
E(): 2.5e-20, (30.6% identity in 451 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1407"
/db_xref="EnsemblGenomes-Tr:CCP44166"
/db_xref="GOA:P9WGX3"
/db_xref="InterPro:IPR001678"
/db_xref="InterPro:IPR006027"
/db_xref="InterPro:IPR018314"
/db_xref="InterPro:IPR023267"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR035926"
/db_xref="UniProtKB/Swiss-Prot:P9WGX3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44166.1"
/translation="MTPRSRGPRRRPLDPARRAAFETLRAVSARDAYANLVLPALLAQ
RGIGGRDAAFATELTYGTCRARGLLDAVIGAAAERSPQAIDPVLLDLLRLGTYQLLRT
RVDAHAAVSTTVEQAGIEFDSARAGFVNGVLRTIAGRDERSWVGELAPDAQNDPIGHA
AFVHAHPRWIAQAFADALGAAVGELEAVLASDDERPAVHLAARPGVLTAGELARAVRG
TVGRYSPFAVYLPRGDPGRLAPVRDGQALVQDEGSQLVARALTLAPVDGDTGRWLDLC
AGPGGKTALLAGLGLQCAARVTAVEPSPHRADLVAQNTRGLPVELLRVDGRHTDLDPG
FDRVLVDAPCTGLGALRRRPEARWRRQPADVAALAKLQRELLSAAIALTRPGGVVLYA
TCSPHLAETVGAVADALRRHPVHALDTRPLFEPVIAGLGEGPHVQLWPHRHGTDAMFA
AALRRLT"
gene 1584499..1585197
/gene="rpe"
/locus_tag="Rv1408"
CDS 1584499..1585197
/codon_start=1
/transl_table=11
/gene="rpe"
/locus_tag="Rv1408"
/product="Probable ribulose-phosphate 3-epimerase Rpe
(PPE) (R5P3E) (pentose-5-phosphate 3-epimerase)"
/note="Rv1408, (MTCY21B4.25), len: 232 aa. Probable
rpe,ribulose-phosphate 3-epimerase, similar to many e.g.
CXEC_ALCEU|P40117 (241 aa), FASTA scores: opt: 638, E():
1.5e-34, (48.3% identity in 234 aa overlap); and
RPE_ECOLI|P32661 ribulose-phosphate 3-epimerase (225
aa),FASTA scores: E(): 0, (46.2% identity in 221 aa
overlap). Contains PS01085 Ribulose-phosphate 3-epimerase
family signature 1. Belongs to the ribulose-phosphate
3-epimerase family."
/db_xref="EnsemblGenomes-Gn:Rv1408"
/db_xref="EnsemblGenomes-Tr:CCP44167"
/db_xref="GOA:P9WI51"
/db_xref="InterPro:IPR000056"
/db_xref="InterPro:IPR011060"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR026019"
/db_xref="UniProtKB/Swiss-Prot:P9WI51"
/inference="protein motif:PROSITE:PS01085"
/inference="protein motif:PROSITE:PS01086"
/protein_id="CCP44167.1"
/translation="MSLMAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMD
GHFVPNLTIGLPVVESLLAVTDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDN
PVGVARDIRAAGAKAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLS
KVRAVRKMVDAGELTILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAA
LRRQAGAASLHLSL"
gene 1585194..1586213
/gene="ribG"
/gene_synonym="ribD"
/locus_tag="Rv1409"
CDS 1585194..1586213
/codon_start=1
/transl_table=11
/gene="ribG"
/gene_synonym="ribD"
/locus_tag="Rv1409"
/product="Probable bifunctional riboflavin biosynthesis
protein RibG : diaminohydroxyphosphoribosylaminopyrimidine
deaminase (riboflavin-specific deaminase) +
5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP
reductase)"
/note="Rv1409, (MTCY21B4.26), len: 339 aa. Probable ribG
(alternate gene name: ribD), bifunctional riboflavin
biosynthesis protein, including
diaminohydroxyphosphoribosylaminopyrimidine deaminase and
5-amino-6-(5-phosphoribosylamino) uracil reductase,
similar to many e.g. RIBD_ECOLI|P25539 riboflavin-specific
deaminase from Escherichia coli (367 aa), FASTA scores:
E(): 0, (39.8% identity in 364 aa overlap); etc. Contains
PS00903 Cytidine and deoxycytidylate deaminases
zinc-binding region signature. In the N-terminal section;
belongs to the cytidine and deoxycytidylate deaminases
family. In the C-terminal section; belongs to the HTP
reductase family."
/db_xref="EnsemblGenomes-Gn:Rv1409"
/db_xref="EnsemblGenomes-Tr:CCP44168"
/db_xref="GOA:P9WPH1"
/db_xref="InterPro:IPR002125"
/db_xref="InterPro:IPR002734"
/db_xref="InterPro:IPR004794"
/db_xref="InterPro:IPR016192"
/db_xref="InterPro:IPR016193"
/db_xref="InterPro:IPR024072"
/db_xref="UniProtKB/Swiss-Prot:P9WPH1"
/inference="protein motif:PROSITE:PS00903"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44168.1"
/translation="MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRI
VGAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGT
VVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKY
ATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADG
SLAPQQPLRVVVGKRDIPPEARVLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPT
LAGAFLRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLL
SLVAR"
gene complement(1586210..1587766)
/gene_synonym="P55"
/locus_tag="Rv1410c"
CDS complement(1586210..1587766)
/codon_start=1
/transl_table=11
/gene_synonym="P55"
/locus_tag="Rv1410c"
/product="Aminoglycosides/tetracycline-transport integral
membrane protein"
/note="Rv1410c, (MTCY21B4.27c), len: 518 aa.
Aminoglycoside/tetracycline-transport integral membrane
protein (see citation below), member of major facilitator
superfamily (MFS), similar to others e.g.
AC22_STRCO|P46105 probable actinorhodin transporter from
Streptomyces coelicolor (578 aa), FASTA scores: opt: 442,
E(): 4.9e-21,(28.5% identity in 466 aa overlap); etc.
Contains PS00216 Sugar transport proteins signature 1.
Could be termed P55. Note that the Rv1410c-Rv1411c operon
seems transcribed from two promoters in Mycobacterium
bovis BCG (see Bigi et al.,2000)."
/db_xref="EnsemblGenomes-Gn:Rv1410c"
/db_xref="EnsemblGenomes-Tr:CCP44169"
/db_xref="GOA:P9WJY3"
/db_xref="InterPro:IPR001411"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJY3"
/inference="protein motif:PROSITE:PS00216"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44169.1"
/translation="MRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMNSVGIPINQL
HRITWIVTMYLLGYIAAMPLLGRASDRFGRKLMLQVSLAGFIIGSVVTALAGHFGDFH
MLIAGRTIQGVASGALLPITLALGADLWSQRNRAGVLGGIGAAQELGSVLGPLYGIFI
VWLLHDWRDVFWINVPLTAIAMVMIHFSLPSHDRSTEPERVDLVGGLLLALALGLAVI
GLYNPNPDGKHVLPDYGAPLLVGALVAAVAFFGWERFARTRLIDPAGVHFRPFLSALG
ASVAAGAALMVTLVDVELFGQGVLQMDQAQAAGMLLWFLIALPIGAVTGGWIATRAGD
RAVAFAGLLIAAYGYWLISHWPVDLLADRHNILGLFTVPAMHTDLVVAGLGLGLVIGP
LSSATLRVVPSAQHGIASAAVVVARMTGMLIGVAALSAWGLYRFNQILAGLSAAIPPN
ASLLERAAAIGARYQQAFALMYGEIFTITAIVCVFGAVLGLLISGRKEHADEPEVQEQ
PTLAPQVEPL"
gene complement(1587772..1588482)
/gene="lprG"
/gene_synonym="P27"
/locus_tag="Rv1411c"
CDS complement(1587772..1588482)
/codon_start=1
/transl_table=11
/gene="lprG"
/gene_synonym="P27"
/locus_tag="Rv1411c"
/product="Conserved lipoprotein LprG"
/note="Rv1411c, (MTCY21B4.28c), len: 236 aa. lprG
(alternate gene name: P27), conserved lipoprotein, similar
to Mycobacterium tuberculosis hypothetical lipoproteins
e.g. Rv1270c|MTCY50.12 (35.1% identity in 245 aa overlap);
Rv1368, Rv2945c. Contains N-terminal signal sequence and
appropriately positioned prokaryotic lipoprotein lipid
attachment site (PS00013). Note that the Rv1410c-Rv1411c
operon seems transcribed from two promoters in
Mycobacterium bovis BCG (see Bigi et al., 2000). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1411c"
/db_xref="EnsemblGenomes-Tr:CCP44170"
/db_xref="GOA:P9WK45"
/db_xref="InterPro:IPR009830"
/db_xref="InterPro:IPR029046"
/db_xref="PDB:3MH8"
/db_xref="PDB:3MH9"
/db_xref="PDB:3MHA"
/db_xref="PDB:4ZRA"
/db_xref="UniProtKB/Swiss-Prot:P9WK45"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44170.1"
/translation="MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPL
VEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDA
DFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTI
NGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQ
MTLSKWGEKVQVTKPPVS"
gene 1588567..1589172
/gene="ribC"
/locus_tag="Rv1412"
CDS 1588567..1589172
/codon_start=1
/transl_table=11
/gene="ribC"
/locus_tag="Rv1412"
/product="Probable riboflavin synthase alpha chain RibC
(RibE)"
/note="Rv1412, (MTCY21B4.29), len: 201 aa. Probable ribC
(ribE), Riboflavin synthase alpha chain, strong similarity
to e.g. RISA_ACTPL|P50854 (215 aa), FASTA scores: opt:
586,E(): 1.8e-33, (50.8% identity in 197 aa overlap).
Contains 2 x PS00693 Riboflavin synthase alpha chain
family signature."
/db_xref="EnsemblGenomes-Gn:Rv1412"
/db_xref="EnsemblGenomes-Tr:CCP44171"
/db_xref="GOA:P9WK35"
/db_xref="InterPro:IPR001783"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR023366"
/db_xref="InterPro:IPR026017"
/db_xref="UniProtKB/Swiss-Prot:P9WK35"
/inference="protein motif:PROSITE:PS00693"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44171.1"
/translation="MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVN
GVCLTVVDVLPDGQFTADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQGH
VDATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFE
VSLIPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSAG"
gene 1589386..1589901
/locus_tag="Rv1413"
CDS 1589386..1589901
/codon_start=1
/transl_table=11
/locus_tag="Rv1413"
/product="Conserved hypothetical protein"
/note="Rv1413, (MTCY21B4.30), len: 171 aa. Conserved
hypothetical protein, similar to part of
AB010956|AB010956_1 metal-activated pyridoxal enzyme from
Arthrobacter sp. (379 aa), FASTA scores: opt: 187, E():
0.00026, (29.0% identity in 162 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1413"
/db_xref="EnsemblGenomes-Tr:CCP44172"
/db_xref="InterPro:IPR001608"
/db_xref="InterPro:IPR029066"
/db_xref="UniProtKB/Swiss-Prot:P9WLY5"
/protein_id="CCP44172.1"
/translation="MATIGEVEVFVDHGADDVFITYPLWIGTRQADRLRQLADRARIA
VGAGTAEGASNTGARLADAAGAIDVLIEIDSGHHRSGVRAEQVLEVAHAVGEAGLHLV
GVFTFPGHSYAPGKPGEAGEQERRALNDAANALVAVGFPISCRSGGSTPTALLTAADG
ASETSRRLCAR"
gene 1589891..1590292
/locus_tag="Rv1414"
CDS 1589891..1590292
/codon_start=1
/transl_table=11
/locus_tag="Rv1414"
/product="Conserved hypothetical protein"
/note="Rv1414, (MTCY21B4.31), len: 133 aa. Conserved
hypothetical protein, similar to C-terminal part of
AB010956|AB010956_1 novel metal-activated pyridoxal enzyme
from Arthrobacter sp. (379 aa), FASTA scores: opt:
163,E(): 0.00063, (32.1% identity in 112 aa overlap).
Rv1413 is similar to N-terminal part of same enzyme
suggesting possible frameshift. Sequence has been checked
and no errors found, it is identical in Mycobacterium
bovis strain AF2122/97 and in Mycobacterium tuberculosis
CDC1551."
/db_xref="EnsemblGenomes-Gn:Rv1414"
/db_xref="EnsemblGenomes-Tr:CCP44173"
/db_xref="GOA:P9WLY3"
/db_xref="InterPro:IPR026956"
/db_xref="InterPro:IPR042208"
/db_xref="UniProtKB/Swiss-Prot:P9WLY3"
/protein_id="CCP44173.1"
/translation="MLGDAQQLELGRCAPADIALTVAATVVSRQDCRSGLRRIVLDCG
SKILGSDRPAWATGFGRLIDHADARIAALSEHHATVVWPDDAPLPPVGTRLRVIPNHV
CLTTNLVDDVAVVRDATLIDRWKVAARGKNH"
gene 1590397..1591674
/gene="ribA2"
/locus_tag="Rv1415"
CDS 1590397..1591674
/codon_start=1
/transl_table=11
/gene="ribA2"
/locus_tag="Rv1415"
/product="Probable riboflavin biosynthesis protein RibA2 :
GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone
4-phosphate synthase (DHBP synthase)"
/note="Rv1415, (MTCY21B4.33), len: 425 aa. Probable
ribA2,Riboflavin biosynthesis protein, similar to many
e.g. GCH2_BACSU|P17620 Bacillus subtilis (398 aa), FASTA
scores: opt: 1388, E(): 0, (55.4% identity in 399 aa
overlap). Also similar to second Mycobacterium
tuberculosis gtp cyclohydrolase Rv1940|ribA1 (353 aa). In
the N-terminal section; belongs to the DHBP synthase
family. In the C-terminal section; belongs to the GTP
cyclohydrolase II family."
/db_xref="EnsemblGenomes-Gn:Rv1415"
/db_xref="EnsemblGenomes-Tr:CCP44174"
/db_xref="GOA:P9WHF1"
/db_xref="InterPro:IPR000422"
/db_xref="InterPro:IPR000926"
/db_xref="InterPro:IPR016299"
/db_xref="InterPro:IPR017945"
/db_xref="InterPro:IPR032677"
/db_xref="InterPro:IPR036144"
/db_xref="UniProtKB/Swiss-Prot:P9WHF1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44174.1"
/translation="MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPE
MVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISA
SDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPA
GAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIP
TRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCD
CGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGL
PADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIR
YLMTKRDKLGHDLAGLDDFHESVHLPGEFGGAL"
gene 1591671..1592153
/gene="ribH"
/locus_tag="Rv1416"
CDS 1591671..1592153
/codon_start=1
/transl_table=11
/gene="ribH"
/locus_tag="Rv1416"
/product="Probable riboflavin synthase beta chain RibH
(6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase)
(lumazine synthase)"
/note="Rv1416, (MTCY21B4.34), len: 160 aa. Probable
ribH,riboflavin synthase beta chain, similar to many e.g.
RISB_ECOLI|P25540 Escherichia coli (156 aa), FASTA scores:
opt: 330, E(): 1.8e-15, (44.1% identity in 145 aa
overlap). Note alternative GTG start possible overlapping
the stop codon of Rv1415|MTCY21B4.33. Belongs to the DMRL
synthase family. N-terminus extended since first
submission (previously 154 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1416"
/db_xref="EnsemblGenomes-Tr:CCP44175"
/db_xref="GOA:P9WHE9"
/db_xref="InterPro:IPR002180"
/db_xref="InterPro:IPR034964"
/db_xref="InterPro:IPR036467"
/db_xref="PDB:1W19"
/db_xref="PDB:1W29"
/db_xref="PDB:2C92"
/db_xref="PDB:2C94"
/db_xref="PDB:2C97"
/db_xref="PDB:2C9B"
/db_xref="PDB:2C9D"
/db_xref="PDB:2VI5"
/db_xref="UniProtKB/Swiss-Prot:P9WHE9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44175.1"
/translation="MKGGAGVPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAA
GCGLDDPTVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLT
RVSLDSSTPIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS
"
gene 1592150..1592614
/locus_tag="Rv1417"
CDS 1592150..1592614
/codon_start=1
/transl_table=11
/locus_tag="Rv1417"
/product="Possible conserved membrane protein"
/note="Rv1417, (MTCY21B4.35), len: 154 aa. Possible
conserved membrane protein, similar to others e.g.
AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA
scores: opt: 212, E(): 4.4e-07, (32.4% identity in 136 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1417"
/db_xref="EnsemblGenomes-Tr:CCP44176"
/db_xref="GOA:P9WLY1"
/db_xref="InterPro:IPR019692"
/db_xref="UniProtKB/Swiss-Prot:P9WLY1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44176.1"
/translation="MTAAPNDWDVVLRPHWTPLFAYAAAFLIAVAHVAGGLLLKVGSS
GVVFQTADQVAMGALGLVLAGAVLLFARPRLRVGSAGLSVRNLLGDRIVGWSEVIGVS
FPGGSRWARIDLADDEYIPVMAIQAVDKDRAVAAMDTVRSLLARYRPDLCAR"
gene 1592639..1593325
/gene="lprH"
/locus_tag="Rv1418"
CDS 1592639..1593325
/codon_start=1
/transl_table=11
/gene="lprH"
/locus_tag="Rv1418"
/product="Probable lipoprotein LprH"
/note="Rv1418, (MTCY21B4.36), len: 228 aa. Probable
lprH,lipoprotein. Contains N-terminal signal sequence and
appropriately positioned prokaryotic lipoprotein lipid
attachment site (PS00013)."
/db_xref="EnsemblGenomes-Gn:Rv1418"
/db_xref="EnsemblGenomes-Tr:CCP44177"
/db_xref="GOA:P9WK43"
/db_xref="UniProtKB/Swiss-Prot:P9WK43"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44177.1"
/translation="MACLGRPGCRGWAGASLVLVVVLALAACTESVAGRAMRATDRSS
GLPTSAKPARARDLLLQDGDRAPFGQVTQSRVGDSYFTSAVPPECSAALLFKGSPLRP
DGSSDHAEAAYNVTGPLPYAESVDVYTNVLNVHDVVWNGFRDVSHCRGDAVGVSRAGR
STPMRLRYFATLSDGVLVWTMSNPRWTCDYGLAVVPHAVLVLSACGFKPGFPMAEWAS
KRRAQLDSQV"
gene 1593505..1593978
/locus_tag="Rv1419"
CDS 1593505..1593978
/codon_start=1
/transl_table=11
/locus_tag="Rv1419"
/product="Unknown protein"
/note="Rv1419, (MTCY21B4.37), len: 157 aa. Unknown
protein. Predicted to be an outer membrane protein (See
Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1419"
/db_xref="EnsemblGenomes-Tr:CCP44178"
/db_xref="GOA:P9WLX9"
/db_xref="InterPro:IPR000772"
/db_xref="InterPro:IPR035992"
/db_xref="UniProtKB/Swiss-Prot:P9WLX9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44178.1"
/translation="MGELRLVGGVLRVLVVVGAVFDVAVLNAGAASADGPVQLKSRLG
DVCLDAPSGSWFSPLVINPCNGTDFQRWNLTDDRQVESVAFPGECVNIGNALWARLQP
CVNWISQHWTVQPDGLVKSDLDACLTVLGGPDPGTWVSTRWCDPNAPDQQWDSVP"
gene 1594042..1595982
/gene="uvrC"
/locus_tag="Rv1420"
CDS 1594042..1595982
/codon_start=1
/transl_table=11
/gene="uvrC"
/locus_tag="Rv1420"
/product="Probable excinuclease ABC (subunit C-nuclease)
UvrC"
/note="Rv1420, (MTCY21B4.38), len: 646 aa. Probable
uvrC,excinuclease ABC, subunit C; nuclease (see citations
below), similar to many e.g. UVRC_PSEFL|P32966 Pseudomonas
fluorescens (607 aa), fasta scores: opt: 738, E():
8.4e-39,(36.6% identity in 629 aa overlap). Belongs to the
UvrC family."
/db_xref="EnsemblGenomes-Gn:Rv1420"
/db_xref="EnsemblGenomes-Tr:CCP44179"
/db_xref="GOA:P9WFC5"
/db_xref="InterPro:IPR000305"
/db_xref="InterPro:IPR001162"
/db_xref="InterPro:IPR001943"
/db_xref="InterPro:IPR003583"
/db_xref="InterPro:IPR004791"
/db_xref="InterPro:IPR010994"
/db_xref="InterPro:IPR035901"
/db_xref="InterPro:IPR036876"
/db_xref="InterPro:IPR038476"
/db_xref="InterPro:IPR041663"
/db_xref="UniProtKB/Swiss-Prot:P9WFC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44179.1"
/translation="MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLT
SYFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKS
YPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGV
FKRHRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQM
NAAAEQLDFERAARLRDDLSALKRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHV
RGGRVRGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDAADESANPVPREVLV
PCLPSNAEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDF
NARSAALQSIQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGI
REAAGQGRSDDVACIAEVTRRRFLRHLRDQSDPDLLSPERKSRRFAYPPNLYVVDGGA
PQVNAASAVIDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQRVRDEA
HRFAITYHRSKRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPG
IGVATATAVHDALRPDSSGAAR"
gene 1595979..1596884
/locus_tag="Rv1421"
CDS 1595979..1596884
/codon_start=1
/transl_table=11
/locus_tag="Rv1421"
/product="Conserved protein"
/note="Rv1421, (MTCY21B4.39), len: 301 aa. Conserved
protein, similar to many hypothetical proteins e.g.
YHBJ_ECOLI|P33995 hypothetical 32.5 kd protein from
Escherichia coli (284 aa), FASTA scores: opt: 648, E():
6.3e-36, (38.7% identity in 282aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1421"
/db_xref="EnsemblGenomes-Tr:CCP44180"
/db_xref="GOA:P9WFQ3"
/db_xref="InterPro:IPR005337"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WFQ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44180.1"
/translation="MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYV
ADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVV
FMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVG
GLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTG
QHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIA
EALMGLLRSDQQLSVRALHRDLGRE"
gene 1596881..1597909
/locus_tag="Rv1422"
CDS 1596881..1597909
/codon_start=1
/transl_table=11
/locus_tag="Rv1422"
/product="Conserved hypothetical protein"
/note="Rv1422, (MTCY21B4.40), len: 342 aa. Conserved
hypothetical protein, similar to many hypothetical
proteins e.g. YAMB_THETU|P38541 Thermoanaerobacterium
thermosulfurigenes (323 aa), FASTA scores: opt: 519, E():
1.6e-25, (33.1% identity in 320 aa overlap); and
AF106003|AF106003_3 Streptomyces coelicolor (363 aa),
FASTA scores: opt: 1047, E(): 0, (54.5% identity in 308 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1422"
/db_xref="EnsemblGenomes-Tr:CCP44181"
/db_xref="GOA:P9WMU5"
/db_xref="InterPro:IPR002882"
/db_xref="InterPro:IPR010119"
/db_xref="InterPro:IPR038136"
/db_xref="UniProtKB/Swiss-Prot:P9WMU5"
/protein_id="CCP44181.1"
/translation="MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRL
RSELDVVPPGDLRMALAALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSE
VLADPVAALDELGRILGVKGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATT
PGKVRRVRLLPTDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATS
ARRALVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRR
TATMLQAEVHFADVARPGTPLHDPGKLAAVLDGVCARDVGASEPPVAATQEIPIDGGR
PRGDDAWR"
gene 1597906..1598883
/gene="whiA"
/locus_tag="Rv1423"
CDS 1597906..1598883
/codon_start=1
/transl_table=11
/gene="whiA"
/locus_tag="Rv1423"
/product="Probable transcriptional regulatory protein
WhiA"
/note="Rv1423, (MTCY21B4.41-MTCY493.31c), len: 325 aa.
Putative whiA, transcriptional regulator, probably
equivalent to AL035591|SCC54.10 whiA protein from
Streptomyces coelicolor (328 aa), FASTA scores: opt:
1505,E(): 0, (70.4% identity in 324 aa overlap). Also some
similarity to O06975|YVCL hypothetical protein from
Bacillus subtilis (316 aa), FASTA scores: E(): 1.8e-0
8,(25.7% identity in 304 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1423"
/db_xref="EnsemblGenomes-Tr:CCP44182"
/db_xref="GOA:P9WF45"
/db_xref="InterPro:IPR003802"
/db_xref="InterPro:IPR018478"
/db_xref="InterPro:IPR023054"
/db_xref="InterPro:IPR027434"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039518"
/db_xref="UniProtKB/Swiss-Prot:P9WF45"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44182.1"
/translation="MTTDVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVE
AELDLGSIARRLRKEIFELYGYTAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLL
DMRGRPVRGLPAQVVGGSIDDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALAL
VGAARRLGVGAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLVWEERRLRREVRAT
ANRLANFDDANLRRSARAAVAAAARVERALEILGDTVPEHLASAGKLRVEHRQASLEE
LGRLADPPMTKDAVAGRIRRLLSMADRKAKVDGIPDTESVVTPDLLEDA"
gene complement(1598893..1599654)
/locus_tag="Rv1424c"
CDS complement(1598893..1599654)
/codon_start=1
/transl_table=11
/locus_tag="Rv1424c"
/product="Possible membrane protein"
/note="Rv1424c, (MTCY21B4.42c,MTCY493.30), len: 253 aa.
Possible membrane protein, contains PS00402
Binding-protein-dependent transport systems inner membrane
comp signature. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1424c"
/db_xref="EnsemblGenomes-Tr:CCP44183"
/db_xref="GOA:P9WLX7"
/db_xref="UniProtKB/Swiss-Prot:P9WLX7"
/inference="protein motif:PROSITE:PS00402"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44183.1"
/translation="MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPP
AEKLVFPVLLGILTLLLSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDS
KLAPSRPQVVACDSREARIRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYC
YPAVTTPGKPPSVLLYAPSACDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGA
GGRCDSASVSLQPPEEIEGPAIPPASSQLVCVAPK"
gene 1599658..1601037
/locus_tag="Rv1425"
CDS 1599658..1601037
/codon_start=1
/transl_table=11
/locus_tag="Rv1425"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv1425, (MTCY21B4.43,MTCY493.29c), len: 459 aa.
Possible triacylglycerol synthase (See Daniel et
al.,2004), similar to many M. tuberculosis proteins e.g.
Rv3740c, Rv3734c, Rv1760, etc."
/db_xref="EnsemblGenomes-Gn:Rv1425"
/db_xref="EnsemblGenomes-Tr:CCP44184"
/db_xref="GOA:P9WKC1"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKC1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44184.1"
/translation="MKRLSSVDAAFWSAETAGWHMHVGALAICDPSDAPEYSFQRLRE
LIIERLPEIPQLRWRVTGAPLGLDRPWFVEDEELDIDFHIRRIGVPAPGGRRELEELV
GRLMSYKLDRSRPLWELWVIEGVEGGRIATLTKMHHAIVDGVSGAGLGEILLDITPEP
RPPQQETVGFVGFQIPGLERRAIGALINVGIMTPFRIVRLLEQTVRQQIAALGVAGKP
ARYFEAPKTRFNAPVSPHRRVTGTRVELARAKAVKDAFGVKLNDVVLALVAGAARQYL
QKRDELPAKPLIAQIPVSTRSEETKADVGNQVSSMTASLATHIEDPAKRLAAIHESTL
SAKEMAKAPSAHQIMGLTETTPPGLLQLAARAYTASGLSHNLAPINLVVSNVPGPPFP
LYMAGARLDSLVPLGPPVMDVALNITCFSYQDYLDFGLVTTPEVANDIDEMADAIEPA
LAELERAAE"
gene complement(1601059..1602321)
/gene="lipO"
/locus_tag="Rv1426c"
CDS complement(1601059..1602321)
/codon_start=1
/transl_table=11
/gene="lipO"
/locus_tag="Rv1426c"
/product="Probable esterase LipO"
/note="Rv1426c, (MTCY493.28), len: 420 aa. Possible
lipO,esterase, similar to several Mycobacterium
tuberculosis hypothetical lipases and esterases e.g.
Rv1399c, Rv2284,etc. Also similar in central region to
AAAD_HUMAN|P22760 human arylacetamide deacetylase (398
aa), FASTA scores: opt:210, E(): 7.6e-07, (29.3% identity
in 191 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1426c"
/db_xref="EnsemblGenomes-Tr:CCP44185"
/db_xref="GOA:O06832"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O06832"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44185.1"
/translation="MRFRRMARPRPLTRAAVELLNAANGLRPLSGSGYSTVLAFWLGW
PTSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRYRGATTPGP
VLEAGLTEQLGPDYAKELATLPTEPMRSRGRNLPLRTAMARRRYVETTNVVCYGPYGR
ANLADIWRRRDLPRDAKAPVLVQVPGGAWVLGWRRPQAYPLMSHLAARGWVCVSLNYR
VSPRHTWPDHIVDVKRALAWVKENIAAYGGDPNFVAISGGSAGGHLCALAALTPNDPR
FQPGFEQVDTSVAAAVPVYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDA
SPIHHVRADAPPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDV
FGSPRAHHTAEAVARFLSWVYATNPPAT"
gene complement(1602321..1603928)
/gene="fadD12"
/locus_tag="Rv1427c"
CDS complement(1602321..1603928)
/codon_start=1
/transl_table=11
/gene="fadD12"
/locus_tag="Rv1427c"
/product="Possible long-chain-fatty-acid--CoA ligase
FadD12 (fatty-acid-CoA synthetase) (fatty-acid-CoA
synthase)"
/note="Rv1427c, (MTCY493.27), len: 535 aa. Possible
fadD12,long-chain-fatty-acid-CoA synthetase, similar to
many e.g. NP_302632.1|NC_002677 acyl-CoA synthase from
Mycobacterium leprae (548 aa); AAD01929.2|AF031419
putative long-chain-fatty-acid--CoA ligase from
Pseudomonas putida (565 aa); NP_419782.1|NC_002696
putative long-chain-fatty-acid--CoA ligase from
Caulobacter crescentus (530 aa); PC60_YEAST|P38137 yeast
peroxisomal-coenzyme A synthetase (543 aa), FASTA scores:
opt: 507, E(): 2.9e-25, (30.4% identity in 365 aa
overlap). Also similar to many M. tuberculosis proteins
e.g. MTCY06A4.14 (44.8% identity in 525 aa overlap).
Contains PS00455 Putative AMP-binding domain signature.
Belongs to the ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv1427c"
/db_xref="EnsemblGenomes-Tr:CCP44186"
/db_xref="GOA:O06831"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O06831"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44186.1"
/translation="MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAG
FAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPRVVGIMCRNHRGF
VDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYDEEFSATVDRALAEKPQA
TRIVAWTDEDHDLTVEKLVAAHAGRRPEHTGSHGKVILLTSGTTGTPKGARHSGGGIG
TLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATLDLID
RHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPDVVIAFMDQFGDV
IYNNYNATEAGMIATATPADLRTAPDTAGRPAEGTEIRILDQQFTEVPTGEVGTIYVR
NDSQFDGYTSGAAKDFHAGFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVE
KTLATHPDVAEAAVIGVDDQQYGQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPR
DIAVLDELPRGITGKILRTELQSRVGS"
gene complement(1603932..1604759)
/locus_tag="Rv1428c"
CDS complement(1603932..1604759)
/codon_start=1
/transl_table=11
/locus_tag="Rv1428c"
/product="Conserved hypothetical protein"
/note="Rv1428c, (MTCY493.26), len: 275 aa. Conserved
hypothetical protein, some similarity to hypothetical
proteins from Mycobacterium tuberculosis e.g.
Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: opt:
355,E(): 5e-16, (32.6% identity in 273 aa overlap); and
Rv1920."
/db_xref="EnsemblGenomes-Gn:Rv1428c"
/db_xref="EnsemblGenomes-Tr:CCP44187"
/db_xref="GOA:O06830"
/db_xref="InterPro:IPR002123"
/db_xref="InterPro:IPR016676"
/db_xref="UniProtKB/TrEMBL:O06830"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44187.1"
/translation="MSETDSPGNGDDAGIGDIGKFDPGLTQRLISVLRPVLKTYHRSQ
VHGLDSFPPGGALVVANHSGGMFPMDVPVFSVDFYDKFGYDRPVYTLSHDILFMGLTG
DLFRRTGYIRATRENAAKALRSGGVVVVFPGGDYDAYRPTFAENVIDFNGRKGYVSTA
VEAGVPIVPAVSIGGQESQLYLSRGTWLARRLGLKRLLRSDILPISFGFPFGFSAAIP
PNLPLPAKIVMQVLDPINLTKQFGEDPDVDAVDEHVRSVMQQALNDLAAKRRFPILG"
gene 1604878..1606146
/locus_tag="Rv1429"
CDS 1604878..1606146
/codon_start=1
/transl_table=11
/locus_tag="Rv1429"
/product="Conserved protein"
/note="Rv1429, (MTCY493.25c), len: 422 aa. Conserved
protein, some similarity to transcriptional regulator
proteins e.g. CDAR_ECOLI|P37047 Carbohydrate diacid
regulator from Escherichia coli (391 aa), FASTA scores:
opt: 210, E(): 3e-06, (27.7% identity in 296 aa overlap).
Also similar to Mycobacterium tuberculosis hypothetical
proteins Rv2370c, Rv1194c, Rv1453, Rv2242, and Rv1186c."
/db_xref="EnsemblGenomes-Gn:Rv1429"
/db_xref="EnsemblGenomes-Tr:CCP44188"
/db_xref="GOA:O06829"
/db_xref="InterPro:IPR025736"
/db_xref="InterPro:IPR041522"
/db_xref="InterPro:IPR042070"
/db_xref="UniProtKB/TrEMBL:O06829"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44188.1"
/translation="MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARM
ADLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLG
HARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRS
GLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRC
LLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLAC
GRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFV
TDVLGDLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQ
NLDDPDAAFRVQMALEVCRWMAPAVLRAKQ"
gene 1606386..1607972
/gene="PE16"
/locus_tag="Rv1430"
CDS 1606386..1607972
/codon_start=1
/transl_table=11
/gene="PE16"
/locus_tag="Rv1430"
/product="PE family protein PE16"
/note="Rv1430, (MTCY493.24c), len: 528 aa. PE16, Member of
the Mycobacterium tuberculosis PE family of proteins (see
citation below), e.g. Y0D4_MYCTU|Q50594 (55.9% identity in
127 aa overlap). The C-terminus shows similarity to
Q49633|LEPB1170_F3_112 hypothetical Mycobacterium leprae
protein (391 aa), FASTA scores: opt: 342, E():
1.2e-13,(29.8% identity in 292 aa overlap). Possible
TMhelix aa 500-522."
/db_xref="EnsemblGenomes-Gn:Rv1430"
/db_xref="EnsemblGenomes-Tr:CCP44189"
/db_xref="GOA:L7N697"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:L7N697"
/protein_id="CCP44189.1"
/translation="MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAA
DEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVDTAA
TGASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPW
TGIPSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAG
VAPSPDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYD
GFADFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLPVSSPDTNTTYILLP
NEDLPLLQPLRGIVPEPLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAV
PPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNA
IFIGQQVLPILVEGPGALVTADTHYLVDAIQDLAAGDLSGFNQNLQLIPATNIALLVF
AAGIPAVAAVAILTGQDFPV"
gene 1608083..1609852
/locus_tag="Rv1431"
CDS 1608083..1609852
/codon_start=1
/transl_table=11
/locus_tag="Rv1431"
/product="Conserved membrane protein"
/note="Rv1431, (MTCY493.23c), len: 589 aa. Conserved
membrane protein, shows strong similarity to another M.
tuberculosis hypothetical protein Rv1132|MTCY22G8.21
(48.2% identity in 585 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1431"
/db_xref="EnsemblGenomes-Tr:CCP44190"
/db_xref="GOA:O06827"
/db_xref="InterPro:IPR021941"
/db_xref="UniProtKB/TrEMBL:O06827"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44190.1"
/translation="MGFLKPDLPDVDHDTWLTQPRRTRLQVVTRDWVEHGFGTPYAVY
LLYLTKIAVYVAAGAAIISLNPGLGGLSRIGDWWTQPIVYQKVIVFTLLFEVLGFGCG
SGPLTGRFWPPIGGFLYWLRPNTIRLPAWPDKVPFTQGDTRTVVDVALYAIVLIGGVW
ALLSPGSPGPGGTPVTAAGDVGLINPVLVVPTIVALGVLGLRDKTIFLAARGEHYWLK
LFVFFFPFTDQIAAFKIIMLCLWWGAATSKLNHHFPYVVAVMTSNNALLRSRVFNPIK
HLLYRDHANDLRPSWLPKLMAHGGGTTAEFLVPGILVLVADGHPWRWFLIGFMVLFHL
NILSNLPMGVPLEWNVFFIFSLCYLFGHYGAITATDLRSPLLLAIVIAVVAVVIMGNL
LPEKISFLPAMRYYAGNWATSIWCFRGDAEATMETSVVKSSALVVNQLAKLYDGATAE
IMTDKVAAFRAMHTHGRALNGLLPRALDDEAHYRIREGEIVAGPLVGWNFGEGHLHNE
QLVAAVQRRCNFADGDLRVIILEGQPIHVQKQWYRIVDAKTGLFEAGYVTVEDMLSRQ
PWPEPGDEFPVHVTTQRGTPSKP"
gene 1609849..1611270
/locus_tag="Rv1432"
CDS 1609849..1611270
/codon_start=1
/transl_table=11
/locus_tag="Rv1432"
/product="Probable dehydrogenase"
/note="Rv1432, (MTCY493.22c), len: 473 aa. Probable
dehydrogenase, shows strong similarity to P49_STRLI|P06108
p49 protein from Streptomyces lividans (469 aa), FASTA
scores: opt: 1362, E(): 0, (44.9% identity in 474 aa
overlap); and weak similarity to other dehydrogenases."
/db_xref="EnsemblGenomes-Gn:Rv1432"
/db_xref="EnsemblGenomes-Tr:CCP44191"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O06826"
/protein_id="CCP44191.1"
/translation="MTTAVVVGAGPNGLAAAIHLARHGVDVQVLEARDTIGGGARSGE
LTVPGVIHDHCSAFHPLGVGSPFWAAIDLQRYGLTWKWPDVDCAHPLDDGTAGVLYRS
IEATAAGLGPDGKRWQRAVGDLAAGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPA
TAMARRFHTERARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSI
TKALAAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRINRSY
RRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADTERQRAQGTMVQRP
FVLVGQQYLADPSRSVGNINPIWAYAHVPFGYTGDATAAVIDQIERFAPGFRDRIVAT
VSTSTTELQTYNRNFIGGDIIGGANDRLQVIFRPRVAVDPYAIGVPGVYLCSQSAPPG
AGIHGLCGYHAAESALRWLRKRR"
gene 1611434..1612249
/locus_tag="Rv1433"
CDS 1611434..1612249
/codon_start=1
/transl_table=11
/locus_tag="Rv1433"
/product="Possible conserved exported protein"
/note="Rv1433, (MTCY493.21c), len: 271 aa. Possible
exported protein with N-terminal signal sequence, highly
similar to Q49706 hypothetical protein from Mycobacterium
leprae (271 aa), FASTA scores: opt: 1341, E(): 0, (68.3%
identity in 271 aa overlap). Also shows similarity to M.
tuberculosis lipoprotein Rv2518c|MTV009.03c lppS (408 aa)
(40.0% identity in 230 aa overlap); and others e.g.
Rv0116c, Rv0192, Rv2518c, Rv0483. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1433"
/db_xref="EnsemblGenomes-Tr:CCP44192"
/db_xref="GOA:O06825"
/db_xref="InterPro:IPR005490"
/db_xref="InterPro:IPR038063"
/db_xref="InterPro:IPR041280"
/db_xref="PDB:4K73"
/db_xref="PDB:6D4K"
/db_xref="PDB:6D51"
/db_xref="UniProtKB/Swiss-Prot:O06825"
/protein_id="CCP44192.1"
/translation="MRAVFGCAIAVVGIAGSVVAGPADIHLVAAKQSYGFAVASVLPT
RGQVVGVAHPVVVTFSAPITNPANRHAAERAVEVKSTPAMTGKFEWLDNDVVQWVPDR
FWPAHSTVELSVGSLSSDFKTGPAVVGVASISQHTFTVSIDGVEEGPPPPLPAPHHRV
HFGEDGVMPASMGRPEYPTPVGSYTVLSKERSVIMDSSSVGIPVDDPDGYRLSVDYAV
RITSRGLYVHSAPWALPALGLENVSHGCISLSREDAEWYYNAVDIGDPVIVQE"
gene 1612256..1612393
/locus_tag="Rv1434"
CDS 1612256..1612393
/codon_start=1
/transl_table=11
/locus_tag="Rv1434"
/product="Hypothetical protein"
/note="Rv1434, (MTCY493.20c), len: 45 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1434"
/db_xref="EnsemblGenomes-Tr:CCP44193"
/db_xref="UniProtKB/TrEMBL:O06824"
/protein_id="CCP44193.1"
/translation="MRASPAERVDGAYAGAGPHTQSVLEEDQRQRAPAGAEAEGPGRT
G"
gene complement(1612342..1612950)
/locus_tag="Rv1435c"
CDS complement(1612342..1612950)
/codon_start=1
/transl_table=11
/locus_tag="Rv1435c"
/product="Probable conserved proline, glycine, valine-rich
secreted protein"
/note="Rv1435c, (MTCY493.19), len: 202 aa. Probable
conserved Pro-, Gly-, Val-rich secreted protein (see
citation below) with a N-terminal signal sequence. Similar
at C-terminus to AF017099|AF017099_1 Mycobacterium
tuberculosis pGB1 (87 aa), FASTA scores: opt: 550, E():
2.3e-17, (97.7% identity in 86 aa overlap). Shows some
similarity to N-terminus of CPN_DROME|Q02910 calphotin.
Drosophila melanogaster (865 aa), FASTA scores: opt:
266,E(): 2.5e-05, (37.2% identity in 191 aa overlap).
Contains at least five 7 aa imperfect repeats. Also shows
similarity to other Mycobacterium tuberculosis proteins
e.g. MTCI237.20c (34.7% identity in 193 aa overlap),
MTCI65.25c (36.9% identity in 160 aa overlap) and
MTCI65.24c (34.2% identity in 196 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1435c"
/db_xref="EnsemblGenomes-Tr:CCP44194"
/db_xref="GOA:O06823"
/db_xref="UniProtKB/TrEMBL:O06823"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44194.1"
/translation="MTLMAIVNRFNIKVIAGAGLFAAAIALSPDAAADPLMTGGYACI
QGMAGDAPVAAGDPVAAGGPAAAGACSAALTDMAGVPFVAPGPVPAAAPVPIGAPVPI
PGAPVPIPGAPVPIPGGPVPIPGAPVPVPAVPAPVIPVGTPLIALGPVLAGAPGDGVV
SAPIIGMSGVKDALTDPAPAGGPVPGQPVLPGPSASAPAGAR"
repeat_region complement(1612558..1612578)
/locus_tag="Rv1435c"
/note="21 bp imperfect direct repeat
5,GGCGCACCGGTACCGGTACCC"
repeat_region complement(1612579..1612599)
/locus_tag="Rv1435c"
/note="21 bp imperfect direct repeat
4,GGCGGACCGGTACCGATACCG"
repeat_region complement(1612600..1612620)
/locus_tag="Rv1435c"
/note="21 bp imperfect direct repeat
3,GGCGCACCGGTACCAATCCCC"
repeat_region complement(1612621..1612641)
/locus_tag="Rv1435c"
/note="21 bp imperfect direct repeat
2,GGCGCACCGGTACCGATACCG"
repeat_region complement(1612642..1612662)
/locus_tag="Rv1435c"
/note="21 bp imperfect direct repeat
1,GGCGCACCGGTACCAATCCCT"
gene 1613307..1614326
/gene="gap"
/locus_tag="Rv1436"
CDS 1613307..1614326
/codon_start=1
/transl_table=11
/gene="gap"
/locus_tag="Rv1436"
/product="Probable glyceraldehyde 3-phosphate
dehydrogenase Gap (GAPDH)"
/note="Rv1436, (MTCY493.18c), len: 339 aa. Probable
gap,Glyceraldehyde 3-phosphate dehydrogenase, highly
similar to many e.g. G3P_MYCLE|P46713 Mycobacterium leprae
(339 aa),FASTA scores: opt: 1933, E():0, (89.1% identity
in 339 aa overlap). Contains PS00071 Glyceraldehyde
3-phosphate dehydrogenase active site. Belongs to the
glyceraldehyde 3-phosphate dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv1436"
/db_xref="EnsemblGenomes-Tr:CCP44195"
/db_xref="GOA:P9WN83"
/db_xref="InterPro:IPR006424"
/db_xref="InterPro:IPR020828"
/db_xref="InterPro:IPR020829"
/db_xref="InterPro:IPR020830"
/db_xref="InterPro:IPR020831"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN83"
/inference="protein motif:PROSITE:PS00071"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44195.1"
/translation="MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNS
TLAHLLKFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVVE
STGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTT
NCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGA
AKAIGLVMPQLKGKLDGYALRVPIPTGSVTDLTVDLSTRASVDEINAAFKAAAEGRLK
GILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTL
VGKSL"
gene 1614329..1615567
/gene="pgk"
/locus_tag="Rv1437"
CDS 1614329..1615567
/codon_start=1
/transl_table=11
/gene="pgk"
/locus_tag="Rv1437"
/product="Probable phosphoglycerate kinase Pgk"
/note="Rv1437, (MTCY493.17c), len: 412 aa. Probable
pgk,Phosphoglycerate kinase, highly similar to many e.g.
PGK_MYCLE|P46712 Mycobacterium leprae (416 aa), FASTA
scores: opt: 2153, E(): 0, (80.4% identity in 414 aa
overlap). Contains PS00111 Phosphoglycerate kinase
signature. Belongs to the phosphoglycerate kinase family."
/db_xref="EnsemblGenomes-Gn:Rv1437"
/db_xref="EnsemblGenomes-Tr:CCP44196"
/db_xref="GOA:P9WID1"
/db_xref="InterPro:IPR001576"
/db_xref="InterPro:IPR015824"
/db_xref="InterPro:IPR015911"
/db_xref="InterPro:IPR036043"
/db_xref="UniProtKB/Swiss-Prot:P9WID1"
/inference="protein motif:PROSITE:PS00111"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44196.1"
/translation="MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIAS
APTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGAD
ALARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVV
HRKQASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIES
LATKADSIVIGGGMCFTFLAAQGFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVV
TEKFAADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPA
YAAGTRGVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLE
GKTLPGIEVLSREQPTGGVL"
gene 1615564..1616349
/gene="tpi"
/locus_tag="Rv1438"
CDS 1615564..1616349
/codon_start=1
/transl_table=11
/gene="tpi"
/locus_tag="Rv1438"
/product="Probable triosephosphate isomerase Tpi (TIM)"
/note="Rv1438, (MTCY493.16c), len: 261 aa. Probable tpi
(tpiA), Triosephosphate isomerase, highly similar to many
e.g. TPIS_MYCLE|P46711 Mycobacterium leprae (261 aa),
FASTA scores: opt: 1456, E(): 0, (83.9% identity in 261 aa
overlap). Contains PS00171 Triosephosphate isomerase
active site. Belongs to the triosephosphate isomerase
family."
/db_xref="EnsemblGenomes-Gn:Rv1438"
/db_xref="EnsemblGenomes-Tr:CCP44197"
/db_xref="GOA:P9WG43"
/db_xref="InterPro:IPR000652"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR020861"
/db_xref="InterPro:IPR022896"
/db_xref="InterPro:IPR035990"
/db_xref="PDB:3GVG"
/db_xref="PDB:3TA6"
/db_xref="PDB:3TAO"
/db_xref="UniProtKB/Swiss-Prot:P9WG43"
/inference="protein motif:PROSITE:PS00171"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44197.1"
/translation="MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVI
PPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSE
RRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLL
AEQIGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGS
VNAKNVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAGGPLP"
gene complement(1616961..1617386)
/locus_tag="Rv1439c"
CDS complement(1616961..1617386)
/codon_start=1
/transl_table=11
/locus_tag="Rv1439c"
/product="Unknown protein"
/note="Rv1439c, (MTCY493.15), len: 141 aa. Unknown
protein. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1439c"
/db_xref="EnsemblGenomes-Tr:CCP44198"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/TrEMBL:O06820"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44198.1"
/translation="MQMSASNAFVEGFADFWKAPSPDRLTDHLHPDVVLVRPLSPPRH
GLGAAQREFTRILGLLPDLHGEVDRWSQAGDVVFIEFRLIARLGSEVVEWPVVDRFLL
RGDKAVERVSYFDSLPLLIKVVKHPSAWRGWLTTMRSRA"
gene 1617837..1618070
/gene="secG"
/locus_tag="Rv1440"
CDS 1617837..1618070
/codon_start=1
/transl_table=11
/gene="secG"
/locus_tag="Rv1440"
/product="Probable protein-export membrane protein
(translocase subunit) SecG"
/note="Rv1440, (MTCY493.14c), len: 77 aa. Probable
secG,protein-export membrane protein (translocase subunit)
(see citation below), similar to many e.g.
P38388|SECG_MYCLE probable protein-export membrane (77
aa), FASTA scores: opt: 450, E(): 6.7e-24, (96.1% identity
in 77 aa overlap). Start changed since original submission
(-40 aa). Part of the prokaryotic protein translocation
apparatus which comprise SECA|Rv3240c, SECD|Rv2587c,
SECE|Rv0638,SECF|Rv2586c, SECG and SECY|Rv0732."
/db_xref="EnsemblGenomes-Gn:Rv1440"
/db_xref="EnsemblGenomes-Tr:CCP44199"
/db_xref="GOA:P9WGN5"
/db_xref="InterPro:IPR004692"
/db_xref="UniProtKB/Swiss-Prot:P9WGN5"
/protein_id="CCP44199.1"
/translation="MELALQITLIVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSG
STVVEKNLDRLTLFVTGIWLVSIIGVALLIKYR"
gene complement(1618209..1619684)
/gene="PE_PGRS26"
/locus_tag="Rv1441c"
CDS complement(1618209..1619684)
/codon_start=1
/transl_table=11
/gene="PE_PGRS26"
/locus_tag="Rv1441c"
/product="PE-PGRS family protein PE_PGRS26"
/note="Rv1441c, (MTCY493.13), len: 491 aa.
PE_PGRS26,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan &
Delogu 2002),similar to Y0DP_MYCTU|Q50615 hypothetical
glycine-rich 40.8 kDa protein (498 aa), fasta scores: opt:
1625, E(): 0,(55.2% identity in 518 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1441c"
/db_xref="EnsemblGenomes-Tr:CCP44200"
/db_xref="GOA:Q79FP3"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:Q79FP3"
/protein_id="CCP44200.1"
/translation="MSNVMVVPGMLSAAAADVASIGAALSAANGAAAPTTAGVLAAGA
DEVSAAIASLFSGYARDYQALSAQMARFHQQFVQALTASVGSYAAAEAANASPLQALE
QQVLAAINAPTQTLLGRPLIGNGADGLPGQNGGAGGLLWGNGGNGGAGDAAHPNGGNG
GDAGMFGNGGAGGAGYSPAAGTGAAGGAGGAGGAGGWLSGNGGAGGNGGTGASGADGG
GGLPPVPASPGGNGGGGDAGGAAGMFGTGGAGGTGGDGGAGGAGDSPNSGANGARGGD
GGNGAAGGAGGRLFGNGGAGGNGGTAGQGGDGGTALGAGGIGGDGGTGGAGGTGGTAG
IGGSSAGAGGAGGDGGAGGTGGGSSMIGGKGGTGGNGGVGGTGGASALTIGNGSSAGA
GGAGGAGGTGGTGGYIESLDGKGQAGNGGNGGNGAAGGAGGGGTGAGGNGGAGGNGGD
GGPSQGGGNPGFGGDGGTGGPGGVGVPDGIGGANGAQGKHG"
gene 1619791..1622091
/gene="bisC"
/locus_tag="Rv1442"
CDS 1619791..1622091
/codon_start=1
/transl_table=11
/gene="bisC"
/locus_tag="Rv1442"
/product="Probable biotin sulfoxide reductase BisC (BDS
reductase) (BSO reductase)"
/note="Rv1442, (MTCY493.12c), len: 766 aa. Probable
bisC,Biotin sulfoxide reductase, similar to
BISC_ECOLI|P20099 biotin sulfoxide reductase from
Escherichia coli (739 aa),FASTA scores: opt: 1271, E():0,
(40.2% identity in 744 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1442"
/db_xref="EnsemblGenomes-Tr:CCP44201"
/db_xref="GOA:O06817"
/db_xref="InterPro:IPR006656"
/db_xref="InterPro:IPR006657"
/db_xref="InterPro:IPR006658"
/db_xref="InterPro:IPR009010"
/db_xref="InterPro:IPR041460"
/db_xref="InterPro:IPR041954"
/db_xref="UniProtKB/TrEMBL:O06817"
/protein_id="CCP44201.1"
/translation="MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGA
VRHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNE
AIYGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAALFE
ALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSV
SPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYE
RFERYLLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGE
QTVWMAATLAAMLGQIGLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVA
AISELLQRPGQRLAYNGRLLELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVH
EQYWTAMAKHADIVVPTTTSFERDDFAASKTNPTLIAMPAMVPPYANARDDYHTFSAL
AHRLGFGKQFTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWL
ADFRADPAAHPLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLH
LIANQPRTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGAC
LAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTG
QHVLVQIERFTGELPPVRAHEPPRLA"
gene complement(1622207..1622692)
/locus_tag="Rv1443c"
CDS complement(1622207..1622692)
/codon_start=1
/transl_table=11
/locus_tag="Rv1443c"
/product="Unknown protein"
/note="Rv1443c, (MTCY493.11), len: 161 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1443c"
/db_xref="EnsemblGenomes-Tr:CCP44202"
/db_xref="GOA:O06816"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O06816"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44202.1"
/translation="MVGYAEPVLIERQSVVAAPAEQVWQRVVTPEGINDELRPWMTMS
VPRGAKGMTVDTVPIGAPIGRAWLRLFGVLPFDYDRLSIAELEPGRRFREDSTMLSMR
QWQHERTVTPEGDTKTIVRDRITFQTRAGLRFAAPLIAAGLRALFGHRHRRLQRHFAQ
G"
gene complement(1623287..1623697)
/locus_tag="Rv1444c"
CDS complement(1623287..1623697)
/codon_start=1
/transl_table=11
/locus_tag="Rv1444c"
/product="Unknown protein"
/note="Rv1444c, (MTCY493.10), len: 136 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1444c"
/db_xref="EnsemblGenomes-Tr:CCP44203"
/db_xref="UniProtKB/TrEMBL:O06815"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44203.1"
/translation="MTVMADRSGRPAPVRRRMKTLTQAALNADKTVEQVEDVLDGLGK
TMAELNSSLSQLNSTVERLEDGLDHLEGTLHSLDDLAKRLIVLVEPVEAIVDRIDYIV
SLGETVMSPLSVTEHAVRGVLDRLRNRTVHEPTN"
gene complement(1623714..1624457)
/gene="devB"
/locus_tag="Rv1445c"
CDS complement(1623714..1624457)
/codon_start=1
/transl_table=11
/gene="devB"
/locus_tag="Rv1445c"
/product="Probable 6-phosphogluconolactonase DevB (6PGL)"
/note="Rv1445c, (MTCY493.09), len: 247 aa. Possible devB
(PGL), 6-phosphogluconolactonase, belongs to a different
family to the upstream gene zwf2. Similar to e.g.
DEVB_ANASP|P46016 putative glucose-6-phosphate
1-dehydrogenase (239 aa), FASTA scores: opt: 439, E():
2.6e-20, (34.0% identity in 247 aa overlap). Belongs to
the glucosamine/galactosamine-6-phosphate isomerase
family. 6-phosphogluconolactonase subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1445c"
/db_xref="EnsemblGenomes-Tr:CCP44204"
/db_xref="GOA:P9WQP5"
/db_xref="InterPro:IPR005900"
/db_xref="InterPro:IPR006148"
/db_xref="InterPro:IPR037171"
/db_xref="InterPro:IPR039104"
/db_xref="PDB:3ICO"
/db_xref="UniProtKB/Swiss-Prot:P9WQP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44204.1"
/translation="MSSSIEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGG
NGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQV
HPMAASDGDFGGDLDAAALAYEQVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHS
PAVLESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGAD
PVSVPAAGAVGRQNTLWLLDRDAAAKLPS"
gene complement(1624454..1625365)
/gene="opcA"
/locus_tag="Rv1446c"
CDS complement(1624454..1625365)
/codon_start=1
/transl_table=11
/gene="opcA"
/locus_tag="Rv1446c"
/product="Putative OXPP cycle protein OpcA"
/note="Rv1446c, (MTCY493.08), len: 303 aa. Putative
opcA,OxPP cycle protein. Highly similar to S72774
B1496_F1_30 protein from Mycobacterium leprae (265 aa),
FASTA scores: opt: 1056, E(): 0, (70.3% identity in 239 aa
overlap). Also similar to OPCA_NOSS2|P48971 putative
oxppcycle protein opca from Nostoc punctiforme (465 aa),
fasta scores: opt: 177, E(): 7.3e-05, (23.4% identity in
321 aa overlap). Aids in G6PD activity."
/db_xref="EnsemblGenomes-Gn:Rv1446c"
/db_xref="EnsemblGenomes-Tr:CCP44205"
/db_xref="GOA:O06813"
/db_xref="InterPro:IPR004555"
/db_xref="UniProtKB/TrEMBL:O06813"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44205.1"
/translation="MIVDLPDTTTTAVNKKLDELREKIGAVAMGRVLTLIIAPDSEAM
LEESIEAANDASHEHPSRIIVTMRGDPYADRPRLDAQLRVGADAGAGEFVVLRLSGPL
AGHADSVVIPFLLPDIPVVAWWPDIAPAVPAQDALGKLAIRRITDATNAIDPLSAIKS
RLAGYGAGDTDLAWSRITYWRALLTSAVDQPRHEPIESALVSGLKTEPALDVLAGWLA
SRIEGPVRRAVGELKVELVRNSETIVLSRPQEGITATLTRTGKPDALVPLARRVTGEC
LAEDLRRLDPDEIYCAALEGIKKVQYR"
repeat_region complement(1625366..1625418)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene complement(1625418..1626962)
/gene="zwf2"
/locus_tag="Rv1447c"
CDS complement(1625418..1626962)
/codon_start=1
/transl_table=11
/gene="zwf2"
/locus_tag="Rv1447c"
/product="Probable glucose-6-phosphate 1-dehydrogenase
Zwf2 (G6PD)"
/note="Rv1447c, (MTCY493.07), len: 514 aa. Probable zwf2
(ZWF), Glucose-6-phosphate 1-dehydrogenase, highly similar
to many e.g. G6PD_SYNY3|P73411 Synechocystis sp. (509
aa),FASTA scores: opt: 1578, E(): 0, (46.8% identity in
509 aa overlap). Also similar to M. tuberculosis Rv1121,
zwf glucose-6-phosphate 1-dehydrogenase. Contains PS00069
Glucose-6-phosphate dehydrogenase active site.
Mycobacterium tuberculosis has two genes for ZWF. This one
looks like a classical ZWF. Belongs to the
glucose-6-phosphate dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv1447c"
/db_xref="EnsemblGenomes-Tr:CCP44206"
/db_xref="GOA:P9WN73"
/db_xref="InterPro:IPR001282"
/db_xref="InterPro:IPR019796"
/db_xref="InterPro:IPR022674"
/db_xref="InterPro:IPR022675"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN73"
/inference="protein motif:PROSITE:PS00069"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44206.1"
/translation="MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKK
VMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLA
EGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSG
LARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILA
LRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALT
AMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGF
AEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMT
DELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLI
LDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTG
REWRRP"
gene complement(1626959..1628080)
/gene="tal"
/locus_tag="Rv1448c"
CDS complement(1626959..1628080)
/codon_start=1
/transl_table=11
/gene="tal"
/locus_tag="Rv1448c"
/product="Probable transaldolase Tal"
/note="Rv1448c, (MTCY493.06), len: 373 aa. Probable
tal,Transaldolase, highly similar to many e.g.
TAL_MYCLE|P55193 transaldolase from Mycobacterium leprae
(375 aa), FASTA scores: opt: 1891, E(): 0, (78.6% identity
in 370 aa overlap). Belongs to the transaldolase family."
/db_xref="EnsemblGenomes-Gn:Rv1448c"
/db_xref="EnsemblGenomes-Tr:CCP44207"
/db_xref="GOA:P9WG33"
/db_xref="InterPro:IPR001585"
/db_xref="InterPro:IPR004732"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR018225"
/db_xref="UniProtKB/Swiss-Prot:P9WG33"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44207.1"
/translation="MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVG
VTTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDS
DGVDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAE
GISVNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRL
DRIGSRQALELRGQAGVANARLAYATYREVFEDSDRYRSLKVDGARVQRPLWASTGVK
NPDYSDTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAI
GIDLTDVFAVLEEEGVRKFEASWNELLQETRAHLDTAAQ"
gene complement(1628097..1630199)
/gene="tkt"
/locus_tag="Rv1449c"
CDS complement(1628097..1630199)
/codon_start=1
/transl_table=11
/gene="tkt"
/locus_tag="Rv1449c"
/product="Transketolase Tkt (TK)"
/note="Rv1449c, (MTCY493.05), len: 700 aa.
tkt,transketolase. Highly similar to several e.g.
TKT_MYCLE|P46708 transketolase (tk) from Mycobacterium
leprae (699 aa), FASTA scores: opt: 4216, E(): 0, (89.1%
identity in 700 aa overlap). Start site chosen by
homology. Contains PS00801 Transketolase signature 1.
Belongs to the transketolase family. Thought to be
differentially expressed within host cells (see Triccas et
al., 1999)."
/db_xref="EnsemblGenomes-Gn:Rv1449c"
/db_xref="EnsemblGenomes-Tr:CCP44208"
/db_xref="GOA:P9WG25"
/db_xref="InterPro:IPR005474"
/db_xref="InterPro:IPR005475"
/db_xref="InterPro:IPR005478"
/db_xref="InterPro:IPR009014"
/db_xref="InterPro:IPR020826"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR033247"
/db_xref="InterPro:IPR033248"
/db_xref="PDB:3RIM"
/db_xref="UniProtKB/Swiss-Prot:P9WG25"
/inference="protein motif:PROSITE:PS00801"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44208.1"
/translation="MTTLEEISALTRPRHPDYWTEIDSAAVDTIRVLAADAVQKVGNG
HPGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLE
LSDIESLRTWGSKTPGHPEFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDA
EPGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIA
LCEDTAARYRAYGWHVQEVEGGENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNL
MDTGKAHGAALGDDEVAAVKKIVGFDPDKTFQVREDVLTHTRGLVARGKQAHERWQLE
FDAWARREPERKALLDRLLAQKLPDGWDADLPHWEPGSKALATRAASGAVLSALGPKL
PELWGGSADLAGSNNTTIKGADSFGPPSISTKEYTAHWYGRTLHFGVREHAMGAILSG
IVLHGPTRAYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEH
LSALRAIPRLSVVRPADANETAYAWRTILARRNGSGPVGLILTRQGVPVLDGTDAEGV
ARGGYVLSDAGGLQPGEEPDVILIATGSEVQLAVAAQTLLADNDILARVVSMPCLEWF
EAQPYEYRDAVLPPTVSARVAVEAGVAQCWHQLVGDTGEIVSIEHYGESADHKTLFRE
YGFTAEAVAAAAERALDN"
gene complement(1630638..1634627)
/gene="PE_PGRS27"
/locus_tag="Rv1450c"
CDS complement(1630638..1634627)
/codon_start=1
/transl_table=11
/gene="PE_PGRS27"
/locus_tag="Rv1450c"
/product="PE-PGRS family protein PE_PGRS27"
/note="Rv1450c, (MTCY493.04), len: 1329 aa.
PE_PGRS27,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan
and Delogu,2002), similar to Y03A_MYCTU|Q10637
hypothetical glycine-rich 49.6 kDa protein (603 aa), fasta
scores: opt: 2112, E(): 0, (56.5% identity in 630 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1450c"
/db_xref="EnsemblGenomes-Tr:CCP44209"
/db_xref="GOA:Q79FP2"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FP2"
/protein_id="CCP44209.1"
/translation="MSLVIVAPETVAAAALDVARIGSSIGAANAAAAGSTTSVLAAGA
DEVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLE
HNVLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGA
GGAAGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAG
LFGVGGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGG
AAGLLGVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAG
GAGGAGGVGGTGGAGGAGFSRALIVAGDNGGDPGAGGAGGTGGAGSTIGAHGAAGASP
TSGGNGGAGGNGAHFSSGGKAGGNGGAGGAGGLVGNGGAGGAGGNGAPGAPPSGGDPN
GGGGGAGGAGGKGGDGGAQAGDGGAGGAGGKGGNGGNGATGATGLNGLGAGADGTDGG
KGGNGGAGGGGGAGGQGGKALAATHQDGSMGAGGAGGNGGAGGMGGDGGNGAKGTFDN
GGDGVGGNGGNGGSRGIGGAGGIGGAGSTAGADGARGATPTSGGNGGTGGNGANATVA
GGAGGAGGKGGNGGLVGNGGAGGKGGDGMAGVAGSSPTTAGESGTSGQNGGAGGAGGA
GGRGGDFGGDGGTGGAGGNGANGANATTPGAKGGDGGHGGPGAQGGNGGQGGPGGLAG
NLFGQNGIQGVGGSGGKGGAGGLAGDGGNGANGNFAFGDGNGGHGGNGGNPGAGGQGG
SGGAGSTPGAKGAHGFTPTSGGDGGDGGNGGNSQVVGGNGGDGGNGGNGGSAGTGGNG
GRGGDGAFGGMSANATNPGENGPNGNPGGNGGAGGAGGAGLNGGNGGAGGNGGLGGFG
GNGAAGANGVAVGAPGQPGGAGGHGGAGGNGGAGGNGGQGVVSDGAGGAGGAGGDGGA
PGDGANGGNGQGAGAFAGGGGGRGGDGGNAGNAGAGGPGGTGSTAGKAGPAGSILHDG
GNGGHGGHGAASGGNGGPGGHGGNGGNGGTGANGGNGGIGGTGGAGSTGAKGVLGTNE
GDGGDGGRGGNGGRGGNGGQGLTGAGGNGGTGGTPGNGGNGGNGASGDLVTSPGDGGG
GGRGGDAGRGGDAGLGGSSGPGGTPGDWGTGGTGGTGGTGGQGANGGLTGGRGGTGGN
GGNGNTGGTGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTGG
TGDAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGF
GGLGGGEFV"
repeat_region complement(1633531..1634790)
/note="1260 bp imperfect direct repeat 2, first copy at
1637133..1638392"
gene 1635029..1635955
/gene="ctaB"
/locus_tag="Rv1451"
CDS 1635029..1635955
/codon_start=1
/transl_table=11
/gene="ctaB"
/locus_tag="Rv1451"
/product="Probable cytochrome C oxidase assembly factor
CtaB"
/note="Rv1451, (MTCY493.03c), len: 308 aa. Probable
ctaB,cytochrome C oxidase assembly factor, and integral
membrane protein. Highly similar to several Mycobacterium
leprae proteins e.g. Q49685 CYOE cytochrome O ubiquinol
oxidase assembly factor (300 aa), FASTA scores: opt: 1636,
E(): 0,(82.7% identity in 307 aa overlap);
NP_301495.1|NC_002677 putative protoheme IX
farnesyltransferase (321 aa); NP_301495.1|NC_002677
putative protoheme IX farnesyltransferase (321 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1451"
/db_xref="EnsemblGenomes-Tr:CCP44210"
/db_xref="GOA:P9WFR7"
/db_xref="InterPro:IPR000537"
/db_xref="InterPro:IPR006369"
/db_xref="UniProtKB/Swiss-Prot:P9WFR7"
/protein_id="CCP44210.1"
/translation="MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAML
LADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRN
ALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAG
CMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVAT
ERQVTKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPV
RPLRLFLQSNNYLAVVFCALAVDSVIALPTLH"
gene complement(1636004..1638229)
/gene="PE_PGRS28"
/locus_tag="Rv1452c"
CDS complement(1636004..1638229)
/codon_start=1
/transl_table=11
/gene="PE_PGRS28"
/locus_tag="Rv1452c"
/product="PE-PGRS family protein PE_PGRS28"
/note="Rv1452c, (MTCY493.02), len: 741 aa.
PE_PGRS28,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan
and Delogu,2002), similar to Y03A_MYCTU|Q10637
hypothetical glycine-rich 49.6 kDa protein (603 aa), fasta
scores: opt: 2090, E(): 0, (56.3% identity in 641 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1452c"
/db_xref="EnsemblGenomes-Tr:CCP44211"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FP1"
/protein_id="CCP44211.1"
/translation="MSLVIVTPETVAAAASDVARIGSSIGVANSAAAGSTTSVLAAGA
DEVSAAIATLFGSHAREYQAISTQVAAFHDRFAQTLSAAVGSYVSAEATNAAPLATLE
HNVLNALNAPTQALLGRPLIGDGAAGAPGTGQAGGAGGILWGNGGAGGSGAPGQVGGA
GGAAGLFGTGGAGGAGGAGAAGGAGGSGGWLLGNGGVGGAGGQSLLGGATGGAGGNAG
LFGVGGTGGPGGPGGPGGVGGTGGAGGLGGTLYGAGGHGGAGGPGPIGGVGGHGGVGG
AAGLLGVGGHGGAGGHGAEGVAGAAGEDLSPHGTSGGVGGDAGDGGTGGRGGWLAGAG
GAGGAGGVGGTGGAGGAGFSRALIVAGDNGGDGGNGGMGGAGGAGGPGGAGGLISLLG
GQGAGGAGGTGGAGGVGGDRGAGGPGNQAFNAGAGGAGGHGGDPGAGGAGGTGGAGSI
TGAQGAIGATPTSGGNGGAGGNGANATTAGTNGANGGPGGHGGLVGNGGAGGNGANGA
AGTNASDSGAVGGKGNSGGNGGQGGAGGDGGTLAGNGGAGGTGGRGADGGLGGSGAEG
ANATTAGERGQDGGKGGNGGVGGTGGNAVAPGANGGHGGNGGNPGFSGAGGLGGLSGD
GVTRAAQGATPDFADTGGKGGNGGNGANAVAPGGTGASGGAGGNAGAGGKGGENIIGD
GGGGNGGAGGKGGAGTLLGLTVFGDNGGAGVLGDSTDPDGSGGAGGAGGAGGAGGDPT
I"
repeat_region complement(1637133..1638392)
/note="1260 bp imperfect direct repeat 1, second copy at
1633531..1634790"
gene 1638381..1639646
/locus_tag="Rv1453"
CDS 1638381..1639646
/codon_start=1
/transl_table=11
/locus_tag="Rv1453"
/product="Possible transcriptional activator protein"
/note="Rv1453, (MTCY493.01c), len: 421 aa. Possible
transcriptional activator, similar to Q50018 putative
transcriptional activator trx from Mycobacterium leprae
(517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity
in 500 aa overlap). Also highly similar to Mycobacterium
tuberculosis proteins Rv2370c, Rv1194c, Rv2242,
Rv1186c,and to the further upstream ORF's
Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap).
Start changed since first submission (-11 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1453"
/db_xref="EnsemblGenomes-Tr:CCP44212"
/db_xref="GOA:O06807"
/db_xref="InterPro:IPR025736"
/db_xref="InterPro:IPR041522"
/db_xref="InterPro:IPR042070"
/db_xref="UniProtKB/TrEMBL:O06807"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44212.1"
/translation="MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIA
ADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALD
IYRIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERD
KLTRDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLD
RVADAFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATA
PGIEGFRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGN
LESASPALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHV
AVALEAQQWREKPTSDPPAKKESNGTKMR"
gene complement(1639674..1640660)
/gene="qor"
/locus_tag="Rv1454c"
CDS complement(1639674..1640660)
/codon_start=1
/transl_table=11
/gene="qor"
/locus_tag="Rv1454c"
/product="Probable quinone reductase Qor (NADPH:quinone
reductase) (zeta-crystallin homolog protein)"
/note="Rv1454c, (MTV007.01c), len: 328 aa. Probable
qor,quinone oxidoreductase, simiar to U87282|RCU87282_2
quinone oxidoreductase from Rhodobacter capsulatus (323
aa), FASTA scores: opt: 849, E(): 0, (44.7% identity in
329 aa overlap). Also similar to MTCY180.06 Hypothetical
protein from Mycobacterium tuberculosis (334 aa), FASTA
scores: opt: 430, E(): 2e-14, (32.3% identity in 350 aa
overlap). Contains PS01162 Quinone oxidoreductase /
zeta-crystallin signature."
/db_xref="EnsemblGenomes-Gn:Rv1454c"
/db_xref="EnsemblGenomes-Tr:CCP44213"
/db_xref="GOA:O53146"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:4RVS"
/db_xref="PDB:4RVU"
/db_xref="UniProtKB/TrEMBL:O53146"
/inference="protein motif:PROSITE:PS01162"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44213.1"
/translation="MHAIEVTETGGPGVLRHVDQPQPQPGHGELLIKAEAIGVNFIDT
YFRSGQYPRELPFVIGSEVCGTVEAVGPGVTAADTAISVGDRVVSASANGAYAEFCTA
PASLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGLILTQ
WATHLGVRVITTVSTAEKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQAVYD
GVGATTFDASLASLAVRGTLALFGAASGPVPPVDPQRLNAAGSVYLTRPSLFHFTRTG
EEFSWRAAELFDAIGSEAITVAVGGRYPLADALRAHQDLEARKTVGSVVLLP"
gene 1640680..1641543
/locus_tag="Rv1455"
CDS 1640680..1641543
/codon_start=1
/transl_table=11
/locus_tag="Rv1455"
/product="Conserved protein"
/note="Rv1455, (MTV007.02), len: 287 aa. Conserved
protein,some similarity from aa 80-160 to
Z99125|MLCL536.35c hypothetical Mycobacterium leprae
protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08,
(51.3% identity in 78 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1455"
/db_xref="EnsemblGenomes-Tr:CCP44214"
/db_xref="UniProtKB/TrEMBL:O53147"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44214.1"
/translation="MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGW
LSWDDPEIVHADLVILRATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDL
MDRGVPTVPGEVYVPGEPVRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQA
VLVQPGGSGDETVLVFLGGEPSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGV
DPGELLYARAHITGGSRDPRLLELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALER
LGLGPFSHRRP"
gene complement(1641493..1642425)
/locus_tag="Rv1456c"
CDS complement(1641493..1642425)
/codon_start=1
/transl_table=11
/locus_tag="Rv1456c"
/product="Probable unidentified antibiotic-transport
integral membrane ABC transporter"
/note="Rv1456c, (MTV007.03c), len: 310 aa. Possible
unidentified antibiotic-transport integral membrane
protein ABC transporter (see citation below), equivalent
to Z99125|MLCL536.34 from Mycobacterium leprae (311 aa),
FASTA scores: opt: 1607, E(): 0, (83.3% identity in 300 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1456c"
/db_xref="EnsemblGenomes-Tr:CCP44215"
/db_xref="GOA:O53148"
/db_xref="InterPro:IPR003780"
/db_xref="UniProtKB/TrEMBL:O53148"
/protein_id="CCP44215.1"
/translation="MPYDRAVSPSLRVQRVIAAIVILTQGGIAVTGAIVRVTASGLGC
PTWPQCFPGSFTPVVVAEVPRVHQAVEFGNRMVTFAVVIAAALAVLVVTRARRRTEVL
AYAWLMPVSTVVQAMIGGITVRTGLLWWTVAIHLLASMTMVWLAVLLYVKIGQPDDGV
VHELVVSPLRALTALSALNLAAVLVTGTLVTAAGPHAGDRSPSRTVPRLKVEITTLVH
MHSSLLVAYLALLIGLGFGLLAVGATRAILVRLAVLLALVATQAAVGTTQYFTGVPAA
LVAIHVAGAAAVTAATAALWASMGERAQPQPLQR"
gene complement(1642537..1643322)
/locus_tag="Rv1457c"
CDS complement(1642537..1643322)
/codon_start=1
/transl_table=11
/locus_tag="Rv1457c"
/product="Probable unidentified antibiotic-transport
integral membrane ABC transporter"
/note="Rv1457c, (MTV007.04c), len: 261 aa. Possible
unidentified antibiotic-transport integral membrane
protein ABC transporter (see citation below), equivalent
to Z99125|MLCL536.32 from Mycobacterium leprae (265 aa),
FASTA scores: opt: 1415, E(): 0, (83.1% identity in 260 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1457c"
/db_xref="EnsemblGenomes-Tr:CCP44216"
/db_xref="GOA:O86349"
/db_xref="InterPro:IPR000412"
/db_xref="InterPro:IPR004377"
/db_xref="InterPro:IPR013525"
/db_xref="UniProtKB/TrEMBL:O86349"
/protein_id="CCP44216.1"
/translation="MTQTNRPAFPAGTFSPDPRPNAVPLMLAAQFSLELKLLLRNGEQ
LLLTMFIPITLLVGLTLLPMGSFGHNRAATFVPVIMALAVISTAFTGQAIAVAFDRRY
GALKRLGATPLPVWGIIAGKSLAVVAVVFLQAIILGAIGFALGWRPALTALTLGAGII
ALGTAGFAALGLLLGGTLRAEIVLAVANLMWFVFAGFGALTLESNVIPTAFKWVARVT
PSGALTEALSQAMTVSVDWFGIVVLAVWGALAALAALRWFRFT"
gene complement(1643319..1644260)
/locus_tag="Rv1458c"
CDS complement(1643319..1644260)
/codon_start=1
/transl_table=11
/locus_tag="Rv1458c"
/product="Probable unidentified antibiotic-transport
ATP-binding protein ABC transporter"
/note="Rv1458c, (MTV007.05c), len: 313 aa. Possible
unidentified antibiotic-transport ATP-binding protein ABC
transporter (see citation below), equivalent to
Z99125|MLCL536.31 from Mycobacterium leprae (315 aa),
FASTA scores: opt: 1812, E(): 0, (88.0% identity in 308 aa
overlap). Similar to AF027770|AF027770_7 ABC-type
transporter in FxbA region in Mycobacterium smegmatis (284
aa), FASTA scores: opt: 1412, E(): 0, (85.1% identity in
248 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop) and PS00211 ABC transporters family
signature. Belongs to the ATP-binding transport protein
family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1458c"
/db_xref="EnsemblGenomes-Tr:CCP44217"
/db_xref="GOA:O53149"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O53149"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44217.1"
/translation="MNRAPDTPEVVLRLRGVCKRYGSITAVSNLDLDVHDAEVMALLG
PNGAGKTTTVEMCEGFVRPDAGSIEVLGLDPITDNARLRARIGVMLQGGGGYPAARAG
EMLDLVASYAANPLDPHWLLDTLGLTEAARTTYRRLSGGQQQRLALACALVGRPQLVF
LDEPTAGMDAHARVLVWELIDALRRDGVTVVLTTHHLKEAEELADRLVIIDHGVTVAA
GTPAELMRSGAKDQLRFTAPPRLDLSLLASALPEGYQATELTPGEYLVEGPVDPQVLA
TVTAWCAQIDVLATDMRVEQRSLEDVFLDLTGRKLRQ"
repeat_region complement(1644261..1644313)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(1644314..1644364)
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene complement(1644363..1646138)
/locus_tag="Rv1459c"
CDS complement(1644363..1646138)
/codon_start=1
/transl_table=11
/locus_tag="Rv1459c"
/product="Possible conserved integral membrane protein"
/note="Rv1459c, (MTV007.06c), len: 591 aa. Predicted to be
in the GT-C superfamily of glycosyltransferases (See Liu
and Mushegian, 2003). Possible conserved integral membrane
protein, equivalent to MLCL536.30|Z99125 hypothetical
protein from Mycobacterium leprae (593 aa), FASTA scores:
opt: 1670, E(): 0, (78.6% identity in 585 aa overlap).
Also similar to M. tuberculosis protein Rv2174|MTV021.07
(33.1% identity in 523 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1459c"
/db_xref="EnsemblGenomes-Tr:CCP44218"
/db_xref="GOA:O53150"
/db_xref="UniProtKB/Swiss-Prot:O53150"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44218.1"
/translation="MAARHHTLSWSIASLHGDEQAVGAPLTTTELTALARTRLFGATG
TVLMAIGALGAGARPVVQDPTFGVRLLNLPSRIQTVSLTMTTTGAVMMALAWLMLGRF
TLGRRRMSRGKLDRTLLLWMLPLLIAPPMYSKDVYSYLAQSEIGRDGLDPYRVGPASG
LGLGHVFTLSVPSLWRETPAPYGPLFLWIGRGISSLTGENIVAAVLCHRLVVLIGVTL
IVWATPRLAQRCGVAEVSALWLGAANPLLIMHLVAGIHNEALMLGLMLTGVEFALRGL
DMANTPRPSPETWRLGPATIRASRRPELGASPRAGASRAVKPRPEWGPLAMLLAGSIL
ITLSSQVKLPSLLAMGFVTTVLAYRWGGNLRALLLAAAVMASLTLAIMAILGWASGLG
FGWINTLGTANVVRSWMSPPTLLALGTGHVGILLGLGDHTTAVLSLTRAIGVLIITVM
VCWLLLAVLRGRLHPIGGLGVALAVTVLLFPVVQPWYLLWAIIPLAAWATRPGFRVAA
ILATLIVGIFGPTANGDRFALFQIVDATAASAIIVILLIALTYTRLPWRPLAAEQVVT
AAESASKTPATRRPTAAPDAYADST"
gene 1646186..1646992
/locus_tag="Rv1460"
CDS 1646186..1646992
/codon_start=1
/transl_table=11
/locus_tag="Rv1460"
/product="Probable transcriptional regulatory protein"
/note="Rv1460, (MTV007.07), len: 268 aa. Probable
transcriptional regulatory protein. Equivalent to
Z99125|MLCL536.29c hypothetical protein from Mycobacterium
leprae (254 aa), FASTA scores: opt: 1273, E(): 0, (79.6%
identity in 250 aa overlap). Possible helix-turn-helix
motif between aa 68 - 89. Start changed since original
submission."
/db_xref="EnsemblGenomes-Gn:Rv1460"
/db_xref="EnsemblGenomes-Tr:CCP44219"
/db_xref="GOA:O53151"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O53151"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44219.1"
/translation="MTSTTLPHRASLVDRSTEFCHTDVVKIPAVSTTVPAAVSDGHTR
RAIVRLLLESGSITAGEIGDRLGLSAAGVRRHLDALIEAGDAEASAAAPWQQVGRGRP
AKRYRLTAAGRAKLDHSYDDLASAAMRQLREIGGEEAVRTFARRRIDAILADVAPADG
PDDAALEAAAERIATALSKAGYVATTTRVGGPIHGVQICQHHCPVSHVAEEFPELCET
EQQAMAEVLGTHVQRLATIVNGDCACTTHVPLSPAPSPRPPATSTEGASR"
gene 1646989..1649529
/locus_tag="Rv1461"
CDS 1646989..1649529
/codon_start=1
/transl_table=11
/locus_tag="Rv1461"
/product="Conserved protein"
/note="Rv1461, (MTV007.08), len: 846 aa. Conserved
protein. Equivalent of spliced protein from Mycobacterium
leprae MLCL536.28c len: 869. Residues 1-253 represent
N-extein,and 613-846 the C-extein. The intein present from
residues 254 - 612 is different in sequence and site of
the insertion from the one present in MLCL536.28c. FASTA
scores: Z99125|MLCL536_23 Mycobacterium leprae cosmid L536
(869 aa), opt: 1498 E(): 0, (54.1% identity in 917 aa
overlap). The mature protein is similar to
Z99120|BSUB0017_150 hypothetical Bacillus subtilis protein
(465 aa), FASTA scores: opt:1053, E(): 0, (34.8% identity
in 821 aa overlap). The intein shows some similarity to
inteins from U67548|MJU67548_6 Methanococcus jannaschii
(895 aa), FASTA scores: opt: 181, E(): 0.00023, (25.2%
identity in 274 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1461"
/db_xref="EnsemblGenomes-Tr:CCP44220"
/db_xref="GOA:P9WFP7"
/db_xref="InterPro:IPR000825"
/db_xref="InterPro:IPR003586"
/db_xref="InterPro:IPR003587"
/db_xref="InterPro:IPR004042"
/db_xref="InterPro:IPR006141"
/db_xref="InterPro:IPR006142"
/db_xref="InterPro:IPR010231"
/db_xref="InterPro:IPR027434"
/db_xref="InterPro:IPR030934"
/db_xref="InterPro:IPR036844"
/db_xref="InterPro:IPR037284"
/db_xref="UniProtKB/Swiss-Prot:P9WFP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44220.1"
/translation="MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGA
NAQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYF
VRSTEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEA
QGVIFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDI
PLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVG
DFVTGHDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRK
ERNGWKAEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYY
LAEGHACLTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVY
TKAGYAAMRDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRV
HTTSRLWAFQLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPK
QARDCGDYFAVPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHS
AVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPA
VWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGL
VQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFY
LMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG"
gene 1649526..1650719
/locus_tag="Rv1462"
CDS 1649526..1650719
/codon_start=1
/transl_table=11
/locus_tag="Rv1462"
/product="Conserved hypothetical protein"
/note="Rv1462, (MTV007.09), len: 397 aa. Conserved
hypothetical protein. Equivalent to MLCL536.27c|Z99125
hypothetical protein from Mycobacterium leprae (392
aa),FASTA scores: opt: 2059, E(): 0, (80.4% identity in
392 aa overlap). Also similar to nearby Mycobacterium
tuberculosis hypothetical protein Rv1461."
/db_xref="EnsemblGenomes-Gn:Rv1462"
/db_xref="EnsemblGenomes-Tr:CCP44221"
/db_xref="GOA:P9WFP5"
/db_xref="InterPro:IPR000825"
/db_xref="InterPro:IPR011542"
/db_xref="InterPro:IPR037284"
/db_xref="UniProtKB/Swiss-Prot:P9WFP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44221.1"
/translation="MTAPGLTAAVEGIAHNKGELFASFDVDAFEVPHGRDEIWRFTPL
RRLRGLHDGSARATGSATITVSERPGVYTQTVRRGDPRLGEGGVPTDRVAAQAFSSFN
SATLVTVERDTQVVEPVGITVTGPGEGAVAYGHLQVRIEELGEAVVVIDHRGGGTYAD
NVEFVVDDAARLTAVWIADWADNTVHLSAHHARIGKDAVLRHVTVMLGGDVVRMSAGV
RFCGAGGDAELLGLYFADDGQHLESRLLVDHAHPDCKSNVLYKGALQGDPASSLPDAH
TVWVGDVLIRAQATGTDTFEVNRNLVLTDGARADSVPNLEIETGEIVGAGHASATGRF
DDEQLFYLRSRGIPEAQARRLVVRGFFGEIIAKIAVPEVRERLTAAIEHELEITESTE
KTTVS"
gene 1650716..1651516
/locus_tag="Rv1463"
CDS 1650716..1651516
/codon_start=1
/transl_table=11
/locus_tag="Rv1463"
/product="Probable conserved ATP-binding protein ABC
transporter"
/note="Rv1463, (MTV007.10), len: 266 aa. Probable
conserved ATP-binding protein ABC transporter, equivalent
to Z99125|MLCL536.26c putative ABC transporter ATP-binding
protein from Mycobacterium leprae (260 aa), FASTA scores:
opt: 1444, E(): 0, (86.0% identity in 267 aa overlap).
Very similar to U38804|PPU38804_55 ATP-dependent
transporter YCF16 from porphyra purpurea chloroplast (251
aa), FASTA scores: opt: 822, E(): 0, (52.4% identity in
248 aa overlap); and similar to others. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1463"
/db_xref="EnsemblGenomes-Tr:CCP44222"
/db_xref="GOA:O53154"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR010230"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O53154"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44222.1"
/translation="MTILEIKDLHVSVENPAEADHEIPILRGVDLTVKSGETHALMGP
NGSGKSTLSYAIAGHPKYHVTSGTITLDGADVLAMSIDERARAGLFLAMQYPVEVPGV
SMSNFLRSAATAIRGEPPKLRHWVKEVKAAMAALDIDPAFAERSVNEGFSGGEKKRHE
ILQLELLKPKIAILDETDSGLDVDALRVVSEGVNRYAESQHGGILLITHYTRILRYIH
PEYVHVFVGGRIVESGGSELADELDQNGYVRFSPASGRYPHQPAPTGA"
gene 1651518..1652771
/gene="csd"
/locus_tag="Rv1464"
CDS 1651518..1652771
/codon_start=1
/transl_table=11
/gene="csd"
/locus_tag="Rv1464"
/product="Probable cysteine desulfurase Csd"
/note="Rv1464, (MTV007.11), len: 417 aa. Probable
csd,cysteine desulfurase. Equivalent to Q49690|MLCL536.25C
cysteine desulfurase from Mycobacterium leprae (418
aa),FASTA scores: opt: 2333, E(): 0, (85.4% identity in
417 aa overlap); and similar to cysteine desulfurase from
other organisms. Also similar to M. tuberculosis proteins
Rv3025c|ISCS and Rv3778c. Contains PS00595
Aminotransferases class-V pyridoxal-phosphate attachment
site. Belongs to class-V of pyridoxal-phosphate-dependent
aminotransferases. CSD subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1464"
/db_xref="EnsemblGenomes-Tr:CCP44223"
/db_xref="GOA:P9WQ69"
/db_xref="InterPro:IPR000192"
/db_xref="InterPro:IPR010970"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR020578"
/db_xref="UniProtKB/Swiss-Prot:P9WQ69"
/inference="protein motif:PROSITE:PS00595"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44223.1"
/translation="MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQ
VLDAEREFLTASNGAVHRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTKNATEA
LNLVSYVLGDSRFERAVGPGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGR
IDLDSLYLDDRVKVVAFTHHSNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVD
LHELGVDFAAFSGHKMLGPNGIGVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPA
PQRFEAGTPMTSQVVGLAAAARYLGAIGMAAVEAHERELVAAAIEGLSGIDGVRILGP
TSMRDRGSPVAFVVEGVHAHDVGQVLDDGGVAVRVGHHCALPLHRRFGLAATARASFA
VYNTADEVDRLVAGVRRSRHFFGRA"
gene 1652768..1653256
/locus_tag="Rv1465"
CDS 1652768..1653256
/codon_start=1
/transl_table=11
/locus_tag="Rv1465"
/product="Possible nitrogen fixation related protein"
/note="Rv1465, (MTV007.12), len: 162 aa. Possible nitrogen
fixation related protein. Equivalent to Z99125|MLCL536.24c
nitrogen fixation protein NIFU from Mycobacterium leprae
(165 aa), FASTA scores: opt: 870, E(): 0, (81.8% identity
in 165 aa overlap). Also similar to
O32163|Z99120|NIFU_BACSU NifU-like protein from Bacillus
subtilis (147 aa), FASTA scores: opt: 354, E():
4.1e-17,(38.3% identity in 141 aa overlap) and to
AL096839|SCC22.02 hypothetical protein from Streptomyces
coelicolor (156 aa),FASTA scores: opt: 569, E(): 1.2e-31,
(56.3% identity in 158 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1465"
/db_xref="EnsemblGenomes-Tr:CCP44224"
/db_xref="GOA:O53156"
/db_xref="InterPro:IPR002871"
/db_xref="UniProtKB/TrEMBL:O53156"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44224.1"
/translation="MTLRLEQIYQDVILDHYKHPQHRGLREPFGAQVYHVNPICGDEV
TLRVALSEDGTRVTDVSYDGQGCSISQAATSVLTEQVIGQRVPRALNIVDAFTEMVSS
RGTVPGDEDVLGDGVAFAGVAKYPARVKCALLGWMAFKDALAQASEAFEEVTDERNQR
TG"
gene 1653231..1653578
/locus_tag="Rv1466"
CDS 1653231..1653578
/codon_start=1
/transl_table=11
/locus_tag="Rv1466"
/product="Conserved protein"
/note="Rv1466, (MTV007.13), len: 115 aa. Conserved
protein. Equivalent to Z99125|MLCL536.23c hypothetical
protein from Mycobacterium leprae (115 aa), FASTA scores:
opt: 648, E(): 0, (81.7% identity in 115 aa overlap).
Similar to ORF's downstream of sigma factors in
Streptococcus mutans and Streptococcus pneumoniae e.g.
O06451 ORF3 downstream of RpoD (SPDNAGCPO) (109 aa).
Alternative TTG start possible at 13757 then avoids
overlap with MTV007.12."
/db_xref="EnsemblGenomes-Gn:Rv1466"
/db_xref="EnsemblGenomes-Tr:CCP44225"
/db_xref="GOA:O53157"
/db_xref="InterPro:IPR002744"
/db_xref="InterPro:IPR034904"
/db_xref="UniProtKB/TrEMBL:O53157"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44225.1"
/translation="MSETSAPAEELLADVEEAMRDVVDPELGINVVDLGLVYGLDVQD
GDEGTVALIDMTLTSAACPLTDVIEDQSRSALVGSGLVDDIRINWVWNPPWGPDKITE
DGREQLRALGFTV"
gene complement(1653673..1655502)
/gene="fadE15"
/locus_tag="Rv1467c"
CDS complement(1653673..1655502)
/codon_start=1
/transl_table=11
/gene="fadE15"
/locus_tag="Rv1467c"
/product="Probable acyl-CoA dehydrogenase FadE15"
/note="Rv1467c, (MTV007.14c), len: 609 aa. Probable
fadE15,acyl-CoA dehydrogenase, highly similar to
NP_302639.1|NC_002677 acyl-CoA dehydrogenase from
Mycobacterium leprae (611 aa). Also highly similar to many
e.g. T36481 probable acyl-CoA dehydrogenase (fragment)
from Streptomyces coelicolor (491 aa) (has its N-terminus
very shorter); NP_384640.1|NC_003047 putative acyl-CoA
dehydrogenase protein from Sinorhizobium meliloti (598
aa); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain
specific) from Megasphaera elsdenii (383 aa), FASTA
scores: E(): 2e-12, (25.4% identity in 410 aa overlap);
etc. Also highly similar to fadE5|Rv0244c|MTV034.10c
acyl-CoA dehydrogenase from Mycobacterium tuberculosis
(611 aa); and similar to other proteins from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv1467c"
/db_xref="EnsemblGenomes-Tr:CCP44226"
/db_xref="GOA:O53158"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR020953"
/db_xref="InterPro:IPR025878"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:O53158"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44226.1"
/translation="MGHYIANVRDLEFNLLEVLDIGAVLGTGRYSDLDVDTVRTILAE
AARLAEGPIAESFGYADRNPPVFDPNTHSISVPDELAKTVQAIKEAGWWRLGLAEEIG
GMPAPPPLAWAVNEMIYCANPSACFFNLGPVLAQSLYIEGNDEQRRWAAEGVQRGWQA
TMVLTEPDAGSDVGAGRTKAFEQPDGTWHIEGVKRFISGGDVGNTAENIFHLVLARPE
GAGPGTKGLSLFYVPNYLFDPDTFELGARNGVYVTGLEHKMGLKSSPTCELTFGGADV
PAVGYLVGGVHNGIAQMFTVIEHARMTIGVKSAGTLSTGYLNALAFAKERVQGADLTQ
MTDKTAPRVTIMHHPDVRRSLMTQKAYAEGLRALYLYAAAHQDDAVAQRVSGADHDMA
HRVDDLLLPIVKGVGSERAYEILTESLQTLGGSGFLVDYPLEQYIRDAKIDSLYEGTT
AIQALDFFFRKIVRDHGKALQFVLAQVTHTVENIDPSLKPQAELLRTALDDITAMTGA
LTGYLMSAAQHSSDIYKVGLGSVRYLLAVGDLLIGWRLLVLAGVAHAALADGPSQNDE
AFYRGKIAVAAFFAKNMLPKLTGVRSVIENIDDDIMRVPEDAF"
gene complement(1655609..1656721)
/gene="PE_PGRS29"
/locus_tag="Rv1468c"
CDS complement(1655609..1656721)
/codon_start=1
/transl_table=11
/gene="PE_PGRS29"
/locus_tag="Rv1468c"
/product="PE-PGRS family protein PE_PGRS29"
/note="Rv1468c, (MTV007.15c), len: 370 aa.
PE_PGRS29,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below)."
/db_xref="EnsemblGenomes-Gn:Rv1468c"
/db_xref="EnsemblGenomes-Tr:CCP44227"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FP0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44227.1"
/translation="MSFVVANTEFVSGAAGNLARLGSMISAANSAAAAQTTAVAAAGA
DEVSAAVAALFGAHGQTYQVLSAQAAAFHSQFVQALSGGAQAYAAAEATNFGPLQPLF
DVINAPTLALLNRPLIGNGADGTAANPNGQAGGLLIGNGGNGFSPAAGPGGNGGAAGL
LGHGGNGGVGALGANGGAGGTGGWLFGNGGAGGNSGGGGGAGGIGGSAVLFGAGGAGG
ISPNGMGAGGSGGNGGLFFGNGGAGASSFLGGGGAGGRAFLFGDGGAGGAALSAGSAG
RGGDAGFFYGNGGAGGSGAGGASSAHGGAGGQAGLFGNGGEGGDGGALGGNGGNGGNA
QLIGNGGDGGDGGGAGAPGLGGRGGLLLGLPGANGT"
gene 1656963..1658936
/gene="ctpD"
/locus_tag="Rv1469"
CDS 1656963..1658936
/codon_start=1
/transl_table=11
/gene="ctpD"
/locus_tag="Rv1469"
/product="Probable cation transporter P-type ATPase D
CtpD"
/note="Rv1469, (MTV007.16), len: 657 aa. Probable
ctpD,cation-transporting P-type ATPase D (transmembrane
protein), highly similar to others e.g. T35947 probable
cation-transporting ATPase from Streptomyces coelicolor
(638 aa); NP_442633.1|NC_000911 cation-transporting ATPase
(E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (642
aa), FASTA scores: opt: 1438, E(): 0, (41.9% identity in
592 aa overlap); NP_389268.1|NC_000964 protein similar to
heavy metal-transporting ATPase from Bacillus subtilis
(637 aa); etc. Also highly similar to others from
Mycobacterium tuberculosis e.g. Rv3743c|MTV025.091c|CTPJ
(660 aa). Contains PS00154 E1-E2 ATPases phosphorylation
site. Belongs to the cation transport ATPases family
(E1-E2 ATPases), subfamily IB."
/db_xref="EnsemblGenomes-Gn:Rv1469"
/db_xref="EnsemblGenomes-Tr:CCP44228"
/db_xref="GOA:P9WPT3"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR027256"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPT3"
/inference="protein motif:PROSITE:PS00154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44228.1"
/translation="MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVA
LLLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSAWAGAQALRNKALDVDLLMIAAA
VGAVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSER
VVAASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGT
VNGSGVLHLVVTRDPSQTVVARIVELVADASATKAKTQLFIEKIEQRYSLGMVAATLA
LIVIPLMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVV
VERLADTSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGR
AIVAEARRRGIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSA
GATAAIVLLDGVAIGVLGLTDQLRPDAVESVAAMAALTAAPPVLLTGDNGRAAWRVAR
NAGITDVRAALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAMGAGADL
TLQTADGVTIRDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPL
GVVGHEGSTVLVALNGMRLLTNRSWRAAASAAR"
gene 1658980..1659354
/gene="trxA"
/locus_tag="Rv1470"
CDS 1658980..1659354
/codon_start=1
/transl_table=11
/gene="trxA"
/locus_tag="Rv1470"
/product="Probable thioredoxin TrxA"
/note="Rv1470, (MTV007.17), len: 124 aa. Probable
trxA,thioredoxin, similar to many e.g. P12243|THI1_SYNP7
thioredoxin 1 from Synechococcus sp. (106 aa), FASTA
scores: opt: 201, E(): 9.2e-08, (35.4% identity in 99 aa
overlap); etc. Highly similar to downstream ORF
Rv1471|trxB1 probable thioredoxin from Mycobacterium
tuberculosis (123 aa), FASTA scores: opt: 402, E():
0,(54.4% identity in 114 aa overlap). Warning: note that
Rv3914|MT4033|MTV028.05|trxC can be alternatively named
trxA."
/db_xref="EnsemblGenomes-Gn:Rv1470"
/db_xref="EnsemblGenomes-Tr:CCP44229"
/db_xref="GOA:O53161"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:O53161"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44229.1"
/translation="MTTRDLTAAYFQQTISANSNVLVYFWAPLCAPCDLFTPTYEASS
RKHFDVVHGKVNIETEKDLASIAGVKLLPTLMAFKKGKLVFKQAGIANPAIMDNLVQQ
LRAYTFKSPAGEGIGPGTKTSS"
gene 1659370..1659741
/gene="trxB1"
/gene_synonym="trxB"
/locus_tag="Rv1471"
CDS 1659370..1659741
/codon_start=1
/transl_table=11
/gene="trxB1"
/gene_synonym="trxB"
/locus_tag="Rv1471"
/product="Probable thioredoxin TrxB1"
/note="Rv1471, (MTV007.18), len: 123 aa. Probable
trxB1,thioredoxin, similar to many bacterial thioredoxins
e.g. P33636|THI2_ECOLI from Escherichia coli (139 aa),
FASTA scores: opt: 290, E(): 1.8e-13, (44.3% identity in
97 aa overlap); etc. Highly similar to Rv1470|TrxA
probable thioredoxin from Mycobacterium tuberculosis (124
aa), FASTA scores: opt: 402, E(): 1.2e-32, (54.4% identity
in 114 aa overlap). Contains PS00194 Thioredoxin family
active site. Belongs to the thioredoxin family. Note that
previously known as trxB."
/db_xref="EnsemblGenomes-Gn:Rv1471"
/db_xref="EnsemblGenomes-Tr:CCP44230"
/db_xref="GOA:L7N664"
/db_xref="InterPro:IPR005746"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR017937"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:L7N664"
/inference="protein motif:PROSITE:PS00194"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44230.1"
/translation="MTTRDLTAAQFNETIQSSDMVLVDYWASWCGPCRAFAPTFAESS
EKHPDVVHAKVDTEAERELAAAAQIRSIPTIMAFKNGKLLFNQAGALPPAALESLVQQ
LKAYEVEAGEATTQNGRAQQA"
gene 1659763..1660620
/gene="echA12"
/locus_tag="Rv1472"
CDS 1659763..1660620
/codon_start=1
/transl_table=11
/gene="echA12"
/locus_tag="Rv1472"
/product="Possible enoyl-CoA hydratase EchA12 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv1472, (MTV007.19), len: 285 aa. Possible
echA12,enoyl-CoA hydratase, highly similar to
P53526|ECHH_MYCLE|NP_301896.1|NC_002677 possible enoyl-CoA
hydratase/isomerase from Mycobacterium leprae (294
aa),FASTA scores: opt: 1265, E(): 0, (72.0% identity in
271 aa overlap). Also similar to others e.g.
CAA66096.1|X97452 enoyl-CoA isomerase from Escherichia
coli strain K12 (262 aa); CAC44593.1|AL596162 putative
enoyl-CoA hydratase from Streptomyces coelicolor (275 aa);
etc. Also similar to others from Mycobacterium
tuberculosis e.g. ECHA16|Rv2831|MTCY16B7.11c (249 aa),
FASTA scores: opt: 232, E(): 1.3e-15, (33.8% identity in
204 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1472"
/db_xref="EnsemblGenomes-Tr:CCP44231"
/db_xref="GOA:P9WNN7"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/Swiss-Prot:P9WNN7"
/inference="protein motif:PROSITE:PS00166"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44231.1"
/translation="MPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMA
FDVMVPLKEALAQVSYDNSVRVVVLTGAGRGFSPGADHKSAGVVPHVENLTRPTYALR
SMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGL
TASELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAERIGLVSRQVPDEQLLDACYAIA
ARMAGFSRPGIELTKRTLWSGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQ
RAPVFTDDT"
gene 1660656..1662284
/locus_tag="Rv1473"
CDS 1660656..1662284
/codon_start=1
/transl_table=11
/locus_tag="Rv1473"
/product="Probable macrolide-transport ATP-binding protein
ABC transporter"
/note="Rv1473, (MTV007.20), len: 542 aa. Possible
macrolide-transport ATP-binding protein ABC transporter
(see citation below), possibly in EF-3 subfamily. Similar
to many ABC-transporters e.g. D90909_48|YHES_HAEIN from
Synechocystis sp. strain PCC6803 (574 aa), FASTA scores:
opt: 870, E(): 0, (33.3% identity in 525 aa overlap);
P44808|YHES_HAEIN from Haemophilus influenzae (638
aa),FASTA scores: opt: 706, E(): 0, (33.7% identity in 517
aa overlap); etc. Contains two PS00017 ATP/GTP-binding
site motif A (P-loop), and two PS00211 ABC transporter
family signatures. Belongs to the ATP-binding transport
protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1473"
/db_xref="EnsemblGenomes-Tr:CCP44232"
/db_xref="GOA:O53164"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR032781"
/db_xref="UniProtKB/TrEMBL:O53164"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44232.1"
/translation="MITATDLEVRAGARILLAPDGPDLRVQPGDRIGLVGRNGAGKTT
TLRILAGEVEPYAGSVTRAGEIGYLPQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQ
QALMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLR
TLSGGQRRRVELARILFAASESGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTGGL
VVISHNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDEQRRIRERANAERK
AAALRAQAAKLGAKATKAVAAQNMLRRADRMMAALDEERVADKVARIKFPTPAACGRT
PLVANGLGKTYGSLEVFTGVDLAIDRGSRVVILGLNGAGKTTLLRLLAGVEQPDTGVL
EPGYGLRIGYFAQEHDTLDNDATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPA
GTLSGGEKTRLALAGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHD
PGAAAALGPQRVVLLPDGTEDYWSDEYRDLIELA"
gene 1662381..1662572
/locus_tag="Rv1473A"
CDS 1662381..1662572
/codon_start=1
/transl_table=11
/locus_tag="Rv1473A"
/product="Possible transcriptional regulatory protein"
/note="Rv1473A, len: 63 aa. Possible transcriptional
regulator, CDS predicted by GC plot. Similar to
SCI8.24c|AL132644_24 putative transcriptional regulator
from Streptomyces coelicolor (73 aa), FASTA scores: opt:
210, E(): 1.5e-08, (56.15% identity in 57 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1473A"
/db_xref="EnsemblGenomes-Tr:CCP44233"
/db_xref="UniProtKB/TrEMBL:L7N691"
/protein_id="CCP44233.1"
/translation="MRKSKKTRDQLLRELRNAYEGGASIRNLAATTGRSYGSIHSMLR
ESGTTMRGRGGPNRRSRPR"
gene complement(1662641..1663204)
/locus_tag="Rv1474c"
CDS complement(1662641..1663204)
/codon_start=1
/transl_table=11
/locus_tag="Rv1474c"
/product="Probable transcriptional regulatory protein"
/note="Rv1474c, (MTV007.21c), len: 187 aa. Probable
transcription regulator, equivalent to AF0021|AF002133_1
transcriptional regulator from Mycobacterium avium strain
GIR10 (82 aa), FASTA scores: opt: 490, E(): 6.7e-26,
(92.5% identity in 80 aa overlap). Also similar to
Q59431|UIDR_ECOLI UID operon repressor (GUS operon) from
Escherichia coli (196 aa), FASTA scores: opt: 192, E():
5.8e-06, (28.5% identity in 172 aa overlap). Belongs to
the TetR/AcrR family of transcriptional regulators. Helix
turn helix motif predicted at aa 33-54 (+3.40 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1474c"
/db_xref="EnsemblGenomes-Tr:CCP44234"
/db_xref="GOA:O53165"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/Swiss-Prot:O53165"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44234.1"
/translation="MPKVSEDHLAARRRQILDGARRCFAEYGYDKATVRRLEQAIGMS
RGAIFHHFRDKDALFFALAREDTERMAAVASREGLIGVMRDMLAAPDQFDWLATRLEI
ARKLRNDPDFSRGWAERSAELAAATTDRLRRQKQANRVRDDVPSDVLRCYLDLVLDGL
LARLASGEDPQRLAAVLDLVENSVRRS"
gene complement(1663215..1666046)
/gene="acn"
/locus_tag="Rv1475c"
CDS complement(1663215..1666046)
/codon_start=1
/transl_table=11
/gene="acn"
/locus_tag="Rv1475c"
/product="Probable iron-regulated aconitate hydratase Acn
(citrate hydro-lyase) (aconitase)"
/note="Rv1475c, (MTV007.22c), len: 943 aa. Probable
acn,iron-regulated aconitate hydratase, similar to many
e.g. P70920|ACON_BRAJA aconitate hydratase from
Bradyrhizobium japonicum (906 aa), FASTA scores: opt:1912,
E(): 0, (54.8% identity in 958 aa overlap); closest to
AF0021|AF002133_2 Mycobacterium avium strain GIR10 (961
aa), FASTA scores: opt: 5072, E(): 0, (82.8% identity in
943 aa overlap). Note aconitase has an active (4FE-4S) and
an inactive (3FE-4S) forms. The active (4FE-4S) cluster is
part of the catalytic site that interconverts citrate,
cis-aconitase, and isocitrate."
/db_xref="EnsemblGenomes-Gn:Rv1475c"
/db_xref="EnsemblGenomes-Tr:CCP44235"
/db_xref="GOA:O53166"
/db_xref="InterPro:IPR000573"
/db_xref="InterPro:IPR001030"
/db_xref="InterPro:IPR006249"
/db_xref="InterPro:IPR015928"
/db_xref="InterPro:IPR018136"
/db_xref="InterPro:IPR036008"
/db_xref="UniProtKB/Swiss-Prot:O53166"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44235.1"
/translation="MTSKSVNSFGAHDTLKVGEKSYQIYRLDAVPNTAKLPYSLKVLA
ENLLRNEDGSNITKDHIEAIANWDPKAEPSIEIQYTPARVVMQDFTGVPCIVDLATMR
EAIADLGGNPDKVNPLAPADLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRW
GQGAFDDFKVVPPGTGIVHQVNIEYLASVVMTRDGVAYPDTCVGTDSHTTMVNGLGVL
GWGVGGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDVVLTVTEMLRQHGVVG
KFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETIKYLRFTGRTPEQVALV
EAYAKAQGMWHDPKHEPEFSEYLELNLSDVVPSIAGPKRPQDRIALAQAKSTFREQIY
HYVGNGSPDSPHDPHSKLDEVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRV
SNPVRVKSDELGEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPW
VKTTIAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAVNDN
DLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFDFQTQPLGQDKDGK
NVFLRDIWPSQQDVSDTIAAAINQEMFTRNYADVFKGDDRWRNLPTPSGNTFEWDPNS
TYVRKPPYFEGMTAKPEPVGNISGARVLALLGDSVTTDHISPAGAIKPGTPAARYLDE
HGVDRKDYNSFGSRRGNHEVMIRGTFANIRLRNQLLDDVSGGYTRDFTQPGGPQAFIY
DAAQNYAAQHIPLVVFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGM
GVIPLQFPEGKSASSLGLDGTEVFDITGIDVLNDGKTPKTVCVQATKGDGATIEFDAV
VRIDTPGEADYYRNGGILQYVLRNILKSG"
gene 1666204..1666764
/locus_tag="Rv1476"
CDS 1666204..1666764
/codon_start=1
/transl_table=11
/locus_tag="Rv1476"
/product="Possible membrane protein"
/note="Rv1476, (MTV007.23), len: 186 aa. Possibly membrane
protein, TMhelix 138-60. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv1476"
/db_xref="EnsemblGenomes-Tr:CCP44236"
/db_xref="GOA:O53167"
/db_xref="UniProtKB/TrEMBL:O53167"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44236.1"
/translation="MTGPYFPQTIPFLPSYIPQDVDMTAVKAEVAALGVSAPPAATPG
LLEVVQHARDEGIDLKIVLLDHNPPNDTPLRDIATVVGADYSDATVLVLSPNYVGSYS
TQYPRVTLEAGEDHSKTGNPVQSAQNFVHELSTPEFPWSALTIVLLIGVLAAAVGARL
MQLRGRRSATSTDAAPGAGDDLNQGV"
gene 1666990..1668408
/gene="ripA"
/locus_tag="Rv1477"
CDS 1666990..1668408
/codon_start=1
/transl_table=11
/gene="ripA"
/locus_tag="Rv1477"
/product="Peptidoglycan hydrolase"
/note="Rv1477, (MTV007.24), len: 472 aa.
RipA,peptidoglycan hydrolase (see Hett et al., 2007).
Secreted,cell-associated protein. The last 277 residues
are nearly identical to those of AF0060|AF006054_1
hypothetical invasion protein INV1 from Mycobacterium
tuberculosis (277 aa), FASTA scores: opt: 1833, E(): 0,
(98.2% identity in 277 aa overlap); also very similar to
AF0021|AF002133_4 invasin 1 protein from Mycobacterium
avium (273 aa), FASTA scores: opt: 1452, E(): 0, (78.1%
identity in 279 aa overlap). Similar to
Rv1566c|MTCY336.37|Z95586 Mycobacterium tuberculosis
cosmid (230 aa), FASTA scores: opt: 528, E(): 4.4e-20,
(52.0% identity in 150 aa overlap); and weakly similar to
p60 proteins of Listeria spp throughout its length e.g.
M80351|LISIAPB_1 Listeria monocytogenes iap-related
protein (478 aa), FASTA scores: opt: 251, E(): 8e-06,
(24.4% identity in 487 aa overlap). C-terminal domain
highly similar to next orf Rv1478|MTV007.25. Interacts
with RpfB and RpfE (see Hett et al., 2007). Predicted to
be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1477"
/db_xref="EnsemblGenomes-Tr:CCP44237"
/db_xref="GOA:O53168"
/db_xref="InterPro:IPR000064"
/db_xref="InterPro:IPR038765"
/db_xref="PDB:2XIV"
/db_xref="PDB:3NE0"
/db_xref="PDB:3PBC"
/db_xref="PDB:3S0Q"
/db_xref="PDB:4Q4G"
/db_xref="PDB:4Q4N"
/db_xref="PDB:4Q4T"
/db_xref="PDB:6EWY"
/db_xref="UniProtKB/Swiss-Prot:O53168"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44237.1"
/translation="MRRNRRGSPARPAARFVRPAIPSALSVALLVCTPGLATADPQTD
TIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAV
KDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAAKTLSASSQAVMA
NLQRARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRL
AAERDAAQARLQAARLVAWSSEGGQGAPPFRMWDPGSGPAGGRAWDGLWDPTLPMIPS
ANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGILQPTDTGITNAPAGSAQGRI
PRVYGRQASEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFA
GVGIKLPHYSGSQYNLGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGL
KVRVAPVRTAGMTPYVVRYIEY"
gene 1668419..1669144
/locus_tag="Rv1478"
CDS 1668419..1669144
/codon_start=1
/transl_table=11
/locus_tag="Rv1478"
/product="Possible invasion protein"
/note="Rv1478, (MTV007.25), len: 241 aa. Possible invasion
protein. Possibly exported protein, nearly identical to
AF0060|AF006054_2 hypothetical invasion protein INV2 of
Mycobacterium tuberculosis (240 aa), FASTA scores: opt:
1509, E(): 0, (95.0% identity in 241 aa overlap); very
similar to AF0021|AF002133_5 hypothetical invasion protein
INV2 from Mycobacterium avium (244 aa), FASTA scores: opt:
1269, E():0, (78.0% identity in 246 aa overlap). Also
similar to Mycobacterium tuberculosis protein MTCY336.37
and weakly similar to C-terminal segment of p60 proteins
of Listeria spp.e.g. Q01836|P60_LISIN protein P60
precursor (481 aa), FASTA scores: opt: 241, E():4e-07,
(37.7% identity in 122 aa overlap). Highly similar to
C-terminal domain of preceeding ORF Rv1477|MTV007.24 (472
aa), FASTA scores: opt: 864, E(): 0, (60.1% identity in
213 aa overlap). Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1478"
/db_xref="EnsemblGenomes-Tr:CCP44238"
/db_xref="GOA:P9WHU5"
/db_xref="InterPro:IPR000064"
/db_xref="InterPro:IPR038765"
/db_xref="PDB:3PBI"
/db_xref="UniProtKB/Swiss-Prot:P9WHU5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44238.1"
/translation="MRHTRFHPIKLAWITAVVAGLMVGVATPADAEPGQWDPTLPALV
SAGAPGDPLAVANASLQATAQATQTTLDLGRQFLGGLGINLGGPAASAPSAATTGASR
IPRANARQAVEYVIRRAGSQMGVPYSWGGGSLQGPSKGVDSGANTVGFDCSGLVRYAF
AGVGVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGGQHVTLYLGNGQMLEASGSA
GKVTVSPVRKAGMTPFVTRIIEY"
gene 1669283..1670416
/gene="moxR1"
/gene_synonym="moxR"
/locus_tag="Rv1479"
CDS 1669283..1670416
/codon_start=1
/transl_table=11
/gene="moxR1"
/gene_synonym="moxR"
/locus_tag="Rv1479"
/product="Probable transcriptional regulatory protein
MoxR1"
/note="Rv1479, (MTV007.26), len: 377 aa. Probable
moxR1,transcriptional regulatory protein, similar to
X96434|BBGIDBMOX_2 moxR regulator from Borrelia
burgdorferi (329 aa), FASTA scores: opt: 850, E():0,
(43.5% identity in 317 aa overlap); and P. denitrificans.
Highly similar to MoxR homologs of Mycobacterium
tuberculosis and Mycobacterium avium (but these both
differ at C-terminus) e.g. Rv3692, Rv3164c, and
AF0021|AF002133_6 Mycobacterium avium strain GIR10 (309
aa), FASTA scores: opt: 1181, E(): 0, (83.7% identity in
227 aa overlap). Also similar to O33173|AF006054 MoxR
fragment from Mycobacterium tuberculosis (211 aa), FASTA
scores: opt: 1305, E(): 0,(94.3% identity in 212 aa
overlap). Note that previously known as moxR."
/db_xref="EnsemblGenomes-Gn:Rv1479"
/db_xref="EnsemblGenomes-Tr:CCP44239"
/db_xref="GOA:Q79FN7"
/db_xref="InterPro:IPR011703"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041628"
/db_xref="UniProtKB/TrEMBL:Q79FN7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44239.1"
/translation="MTSAGGFPAGAGGYQTPGGHSASPAHEAPPGGAEGLAAEVHTLE
RAIFEVKRIIVGQDQLVERMLVGLLSKGHVLLEGVPGVAKTLAVETFARVVGGTFSRI
QFTPDLVPTDIIGTRIYRQGREEFDTELGPVVANFLLADEINRAPAKVQSALLEVMQE
RHVSIGGRTFPMPSPFLVMATQNPIEHEGVYPLPEAQRDRFLFKINVGYPSPEEEREI
IYRMGVTPPQAKQILSTGDLLRLQEIAANNFVHHALVDYVVRVVFATRKPEQLGMNDV
KSWVAFGASPRASLGIIAAARSLALVRGRDYVIPQDVIEVIPDVLRHRLVLTYDALAD
EISPEIVINRVLQTVALPQVNAVPQQGHSVPPVMQAAAAASGR"
gene 1670413..1671366
/locus_tag="Rv1480"
CDS 1670413..1671366
/codon_start=1
/transl_table=11
/locus_tag="Rv1480"
/product="Conserved protein"
/note="Rv1480, (MTV007.27,MTCY227.01), len: 317 aa.
Conserved protein, last 110 aa residues correspond to
first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa
Mycobacterium avium protein MAV169 (169 aa), FASTA scores:
opt: 642, E(): 0, (84.2% identity in 114 aa overlap). Also
similar to Mycobacterium tuberculosis hypothetical
proteins Rv3163c and Rv3693."
/db_xref="EnsemblGenomes-Gn:Rv1480"
/db_xref="EnsemblGenomes-Tr:CCP44240"
/db_xref="GOA:P9WLX5"
/db_xref="InterPro:IPR002881"
/db_xref="InterPro:IPR036465"
/db_xref="UniProtKB/Swiss-Prot:P9WLX5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44240.1"
/translation="MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVL
HGDHLGLIPGPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVV
DMSASLDFGTACCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQH
QHTMLRTIATMPQAPAGVRGDLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAI
AARHEVLAIEVLDPRDVELPDVGDVVLQDAESGVVREFSIDPALRDDFARAAAAHRAD
VARTIRGCGAPLLSLRTDRDWLADIVRFVASRRRGALAGHQ"
gene 1671377..1672384
/locus_tag="Rv1481"
CDS 1671377..1672384
/codon_start=1
/transl_table=11
/locus_tag="Rv1481"
/product="Probable membrane protein"
/note="Rv1481, (MTCY277.02), len: 335 aa. Probable
membrane protein, highly similar to YS02_MYCAV|O07395
hypothetical 36.1 kDa protein mav335 from Mycobacterium
avium (335 aa),FASTA scores: opt: 1904, E(): 0, (89.0%
identity in 337 aa overlap). Similar to
AF116251|AF116251_1 BatA protein from Bacteroides fragilis
(327 aa), FASTA scores: opt: 317, E(): 2e-12, (26.5%
identity in 340 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1481"
/db_xref="EnsemblGenomes-Tr:CCP44241"
/db_xref="GOA:P9WFJ7"
/db_xref="InterPro:IPR002035"
/db_xref="InterPro:IPR022933"
/db_xref="InterPro:IPR024163"
/db_xref="InterPro:IPR036465"
/db_xref="UniProtKB/Swiss-Prot:P9WFJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44241.1"
/translation="MTLPLLGPMTLSGFAHSWFFLFLFVVAGLVALYILMQLARQRRM
LRFANMELLESVAPKRPSRWRHVPAILLVLSLLLFTIAMAGPTHDVRIPRNRAVVMLV
IDVSQSMRATDVEPSRMVAAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREA
TKNALDKLQFADRTATGEAIFTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTN
PDNPKGAYTAARTAKDQGVPISTISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGG
NSYNAATLAELRAVYSSLQQQIGYETIKGDASVGWLRLGALALALAALAALLINRRLP
T"
gene complement(1672457..1673299)
/locus_tag="Rv1482c"
CDS complement(1672457..1673299)
/codon_start=1
/transl_table=11
/locus_tag="Rv1482c"
/product="Conserved hypothetical protein"
/note="Rv1482c, (MTCY277.03c), len: 280 aa. Conserved
hypothetical protein, highly similar to O07396|AF002133
Mycobacterium avium protein MAV346 (346 aa), FASTA scores:
E(): 0, (65.2% identity in 342 aa overlap); slight
similarity to GRPE_ECOLI|P09372 heat shock protein from E.
coli (197 aa), FASTA scores: opt: 139, E(): 0.012, (28.3%
identity in 159 aa overlap). Similar to Mycobacterium
tuberculosis hypothetical proteins Rv3517,
Rv3555c,Rv3714c, Rv1073, etc. Start changed since first
submission (-59 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1482c"
/db_xref="EnsemblGenomes-Tr:CCP44242"
/db_xref="UniProtKB/TrEMBL:P71763"
/protein_id="CCP44242.1"
/translation="MTDPFLGSEALAAGVLTPYELRSRYVALHKDVYVPQGVELTAQL
RAKALWLRSRRRGVLAGYSASAFHGAKWIDADLPAAIIDTNRRRAPGLQVWEERIEPD
EICVIEGMRVTTPERTALDLTSRFPLDPAVAAVDALIQATDLKVADVEPLIERYRGRR
GMKAARAALDLVDGGAQSPKETWLRLLLIRAGFPRPQTQIAVRNEWGWAEAHLDMGWQ
DIKVAAEYDGDHHLTSRYHYRKDILRHEKVQHRYGWIVVRVVAEDHPADIIRRVGEAR
AFRA"
gene 1673440..1674183
/gene="fabG1"
/gene_synonym="mabA"
/locus_tag="Rv1483"
CDS 1673440..1674183
/codon_start=1
/transl_table=11
/gene="fabG1"
/gene_synonym="mabA"
/locus_tag="Rv1483"
/product="3-oxoacyl-[acyl-carrier protein] reductase FabG1
(3-ketoacyl-acyl carrier protein reductase) (mycolic acid
biosynthesis a protein)"
/note="Rv1483, (MTCY277.04), len: 247 aa. FabG1 (alternate
gene name: mabA), 3-oxoacyl-[acyl-carrier protein]
reductase (see citations below), equivalent to
O07399|FABG_MYCAV 3-oxoacyl-[acyl-carrier protein]
reductase from Mycobacterium avium (255 aa);
P71534|FABG_MYCSM 3-oxoacyl-[acyl-carrier protein]
reductase from Mycobacterium smegmatis (255 aa); and
NP_302228.1|NC_002677 3-oxoacyl-[ACP] reductase (aka MabA)
from Mycobacterium leprae (253 aa). Also highly similar to
many e.g. T36779 probable 3-oxacyl-(acyl-carrier-protein)
reductase from Streptomyces coelicolor (234 aa);
FABG_ECOLI|P25716|NP_415611.1|NC_000913
3-oxoacyl-[acyl-carrier-protein] reductase from
Escherichia coli strain K12 (244 aa), FASTA scores: opt:
664, E(): 6.8e-35, (44.4% identity in 241 aa overlap);
etc. Contains PS00061 Short-chain
dehydrogenases/reductases family signature. Belongs to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1483"
/db_xref="EnsemblGenomes-Tr:CCP44243"
/db_xref="GOA:P9WGT3"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:1UZL"
/db_xref="PDB:1UZM"
/db_xref="PDB:1UZN"
/db_xref="PDB:2NTN"
/db_xref="UniProtKB/Swiss-Prot:P9WGT3"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44243.1"
/translation="MTATATEGAKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAV
THRGSGAPKGLFGVECDVTDSDAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTE
EKFEKVINANLTGAFRVAQRASRSMQRNKFGRMIFIGSVSGSWGIGNQANYAASKAGV
IGMARSIARELSKANVTANVVAPGYIDTDMTRALDERIQQGALQFIPAKRVGTPAEVA
GVVSFLASEDASYISGAVIPVDGGMGMGH"
gene 1674202..1675011
/gene="inhA"
/locus_tag="Rv1484"
CDS 1674202..1675011
/codon_start=1
/transl_table=11
/gene="inhA"
/locus_tag="Rv1484"
/product="NADH-dependent enoyl-[acyl-carrier-protein]
reductase InhA (NADH-dependent enoyl-ACP reductase)"
/note="Rv1484, (MTCY277.05), len: 269 aa.
InhA,NADH-dependent enoyl-[acyl-carrier-protein] reductase
(see citations below). Identical to INHA_MYCTU|P46533
enoyl-[acyl-carrier-protein] reductase from Mycobacterium
tuberculosis and G1155270 Mycobacterium bovis enoyl acp
reductase. Some similarity to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1484"
/db_xref="EnsemblGenomes-Tr:CCP44244"
/db_xref="GOA:P9WGR1"
/db_xref="InterPro:IPR014358"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:1BVR"
/db_xref="PDB:1ENY"
/db_xref="PDB:1ENZ"
/db_xref="PDB:1P44"
/db_xref="PDB:1P45"
/db_xref="PDB:1ZID"
/db_xref="PDB:2AQ8"
/db_xref="PDB:2AQH"
/db_xref="PDB:2AQI"
/db_xref="PDB:2AQK"
/db_xref="PDB:2B35"
/db_xref="PDB:2B36"
/db_xref="PDB:2B37"
/db_xref="PDB:2H9I"
/db_xref="PDB:2IDZ"
/db_xref="PDB:2IE0"
/db_xref="PDB:2IEB"
/db_xref="PDB:2IED"
/db_xref="PDB:2NSD"
/db_xref="PDB:2NTJ"
/db_xref="PDB:2NV6"
/db_xref="PDB:2PR2"
/db_xref="PDB:2X22"
/db_xref="PDB:2X23"
/db_xref="PDB:3FNE"
/db_xref="PDB:3FNF"
/db_xref="PDB:3FNG"
/db_xref="PDB:3FNH"
/db_xref="PDB:3OEW"
/db_xref="PDB:3OEY"
/db_xref="PDB:3OF2"
/db_xref="PDB:4BGE"
/db_xref="PDB:4BGI"
/db_xref="PDB:4BII"
/db_xref="PDB:4BQP"
/db_xref="PDB:4BQR"
/db_xref="PDB:4COD"
/db_xref="PDB:4D0R"
/db_xref="PDB:4D0S"
/db_xref="PDB:4DQU"
/db_xref="PDB:4DRE"
/db_xref="PDB:4DTI"
/db_xref="PDB:4OHU"
/db_xref="PDB:4OIM"
/db_xref="PDB:4OXK"
/db_xref="PDB:4OXN"
/db_xref="PDB:4OXY"
/db_xref="PDB:4OYR"
/db_xref="PDB:4QXM"
/db_xref="PDB:4R9R"
/db_xref="PDB:4R9S"
/db_xref="PDB:4TRJ"
/db_xref="PDB:4TRM"
/db_xref="PDB:4TRN"
/db_xref="PDB:4TRO"
/db_xref="PDB:4TZK"
/db_xref="PDB:4TZT"
/db_xref="PDB:4U0J"
/db_xref="PDB:4U0K"
/db_xref="PDB:4UVD"
/db_xref="PDB:4UVE"
/db_xref="PDB:4UVG"
/db_xref="PDB:4UVH"
/db_xref="PDB:4UVI"
/db_xref="PDB:5COQ"
/db_xref="PDB:5CP8"
/db_xref="PDB:5CPB"
/db_xref="PDB:5CPF"
/db_xref="PDB:5G0S"
/db_xref="PDB:5G0T"
/db_xref="PDB:5G0U"
/db_xref="PDB:5G0V"
/db_xref="PDB:5G0W"
/db_xref="PDB:5JFO"
/db_xref="PDB:5MTP"
/db_xref="PDB:5MTQ"
/db_xref="PDB:5MTR"
/db_xref="PDB:5OIF"
/db_xref="PDB:5OIL"
/db_xref="PDB:5OIM"
/db_xref="PDB:5OIN"
/db_xref="PDB:5OIT"
/db_xref="PDB:5UGS"
/db_xref="PDB:5UGT"
/db_xref="PDB:5UGU"
/db_xref="PDB:6EP8"
/db_xref="PDB:6GGM"
/db_xref="PDB:6GH1"
/db_xref="PDB:6GH4"
/db_xref="PDB:6GHN"
/db_xref="UniProtKB/Swiss-Prot:P9WGR1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44244.1"
/translation="MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRL
RLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTG
MGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNW
MTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLL
EEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL"
gene 1675017..1676051
/gene="hemZ"
/locus_tag="Rv1485"
CDS 1675017..1676051
/codon_start=1
/transl_table=11
/gene="hemZ"
/locus_tag="Rv1485"
/product="Ferrochelatase HemZ (protoheme ferro-lyase)
(heme synthetase)"
/note="Rv1485, (MTCY277.06), len: 344 aa.
HemZ,ferrochelatase (see citation below), similar to many
e.g. HEMZ_BACSU|P32396 ferrochelatase from Bacillus
subtilus (310 aa), FASTA scores: opt:490, E(): 2e-24,
(30.2% identity in 295 aa overlap); etc. Belongs to the
ferrochelatase family."
/db_xref="EnsemblGenomes-Gn:Rv1485"
/db_xref="EnsemblGenomes-Tr:CCP44245"
/db_xref="GOA:P9WNE3"
/db_xref="InterPro:IPR001015"
/db_xref="InterPro:IPR019772"
/db_xref="InterPro:IPR033644"
/db_xref="InterPro:IPR033659"
/db_xref="UniProtKB/Swiss-Prot:P9WNE3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44245.1"
/translation="MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEH
YLHFGGVSPINGINRTLIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVF
ATSAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAAT
VRGDARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPP
QVPWLEPDVTDQLTGLAGAGINAVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYA
RASTPNADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSINGQPCRPPHCVASV
SPARPSAGSP"
gene complement(1676017..1676883)
/locus_tag="Rv1486c"
CDS complement(1676017..1676883)
/codon_start=1
/transl_table=11
/locus_tag="Rv1486c"
/product="Conserved hypothetical protein"
/note="Rv1486c, (MTCY277.07c), len: 288 aa. Conserved
hypothetical protein, highly similar to YS07_MYCAV|O07402
hypothetical 33.5 kDa protein mav321 from Mycobacterium
avium (320 aa), FASTA scores: opt: 1217, E(): 0, (71.1%
identity in 315 aa overlap). Weak similarity to
AL079332|SCI5.07 hypothetical protein from Streptomyces
coelicolor (259 aa), FASTA scores: opt: 131, E():
0.29,(32.3% identity in 279 aa overlap). Start changed
since original submission."
/db_xref="EnsemblGenomes-Gn:Rv1486c"
/db_xref="EnsemblGenomes-Tr:CCP44246"
/db_xref="UniProtKB/Swiss-Prot:P9WLX3"
/protein_id="CCP44246.1"
/translation="MWCPSVSLSIWANAWLAGKAAPDDVLDALSLWAPTQSVAAYDAV
AAGHTGLPWPDVHDAGTVSLLQTLRAAVGRRRLRGTINVVLPVPGDVRGLAAGTQFEH
DALAAGEAVIVANPEDPGSAVGLVPEFSYGDVDEAAQSEPLTPELCALSWMVYSLPGA
PVLEHYELGDAEYALRSAVRSAAEALSTIGLGSSDVAKPRGLVEQLLESSRQHRVPDH
APSRALRVLENAAHVDAIIAVSAGLSRLPIGTQSLSDAQRATDALRPLTAVVRSARMS
AVTAILHSAWPD"
gene 1676941..1677375
/locus_tag="Rv1487"
CDS 1676941..1677375
/codon_start=1
/transl_table=11
/locus_tag="Rv1487"
/product="Conserved membrane protein"
/note="Rv1487, (MTCY277.08), len: 144 aa. Conserved
membrane protein. Highly similar to O07404|AF002133 MAV145
from Mycobacterium avium (145 aa), FASTA scores: opt:
667,E(): 0, (72.5% identity in 142 aa overlap). Also
similar to AL079332|SCI5.05 hypothetical protein from
Streptomyces coelicolor (143 aa), FASTA scores: opt: 344,
E(): 1.3e-15,(44.8% identity in 134 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1487"
/db_xref="EnsemblGenomes-Tr:CCP44247"
/db_xref="GOA:P71767"
/db_xref="InterPro:IPR002810"
/db_xref="UniProtKB/TrEMBL:P71767"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44247.1"
/translation="MPVALIWLIAALVLVGAEALTGDMFLLMLGGGALAASVSSWLLA
WPMWADGAVFLLVSVLLLVLVRPAVRRRLTQTKGVQLGIEALEGKKAVVLGRVARDGG
QVKLDGQVWTARPLNDGDVFEPGDSVTVVQIDGATAVVFKDV"
gene 1677397..1678542
/locus_tag="Rv1488"
CDS 1677397..1678542
/codon_start=1
/transl_table=11
/locus_tag="Rv1488"
/product="Possible exported conserved protein"
/note="Rv1488, (MTCY277.09), len: 381 aa. Possible
exported conserved protein; contains possible N-terminal
signal sequence. Similar to YBBK_ECOLI|P77367 hypothetical
protein ybbK from Escherichia coli (305 aa), FASTA scores:
opt: 716, E(): 0, (37.1% identity in 307 aa overlap).
Similar to stomatin-like proteins e.g. AF065260|AF065260_1
Clostridium difficile (320 aa), FASTA scores: opt: 767,
E(): 0, (42.3% identity in 307 aa overlap). Predicted to
be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1488"
/db_xref="EnsemblGenomes-Tr:CCP44248"
/db_xref="GOA:P9WPR9"
/db_xref="InterPro:IPR001107"
/db_xref="InterPro:IPR001972"
/db_xref="InterPro:IPR018080"
/db_xref="InterPro:IPR036013"
/db_xref="UniProtKB/Swiss-Prot:P9WPR9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44248.1"
/translation="MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYS
RTVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQA
AVYEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRV
ARVELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAE
GAKQAAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAY
QYLQTLPEMARGDANKVWVVPSDFNAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHA
ADGDDAEVAGWFSTDTDPSIARAVATAEAIARKPVEGSLGTPPRLTQ"
gene 1678552..1678908
/locus_tag="Rv1489"
CDS 1678552..1678908
/codon_start=1
/transl_table=11
/locus_tag="Rv1489"
/product="Conserved protein"
/note="Rv1489, len: 118 aa. Conserved protein, similar to
hypothetical proteins from Mycobacterium avium subsp.
paratuberculosis and Streptomyces coelicolor e.g.
AJ250017_1 insertion sequence IS900, Locus 3, putative
invasion protein from M. paratuberculosis (138 aa), FASTA
scores: opt: 120, E(): 0.26, (34.375% identity in 96 aa
overlap); SCD6.11c|AL353815_11 possible integral membrane
protein from Streptomyces coelicolor (136 aa), FASTA
scores: opt: 106, E(): 2.2, (35.9% identity in 103 aa
overlap). ORF predicted by GC plot. Replaces previous
Rv1489c on other strand."
/db_xref="EnsemblGenomes-Gn:Rv1489"
/db_xref="EnsemblGenomes-Tr:CCP44249"
/db_xref="GOA:L7N692"
/db_xref="InterPro:IPR032808"
/db_xref="UniProtKB/TrEMBL:L7N692"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44249.1"
/translation="MSGLTSPKTYAVLAALQAGDAVACAIPLPPIARLLDDLDVPVSV
RPVLPVVKAASAVGLLSVTRFPALARLTTAMLTLYFILAVGAHVRVRDRVVNAIPAAS
FLTLFALMTAKGPERT"
gene 1678942..1679172
/locus_tag="Rv1489A"
CDS 1678942..1679172
/codon_start=1
/transl_table=11
/locus_tag="Rv1489A"
/product="Conserved protein"
/note="Rv1489A, len: 76 aa. Conserved protein, similar to
part of alpha subunit of many methylmalonyl-CoA mutases
(~750 aa). Size difference suggests possible gene fragment
although Mycobacterium tuberculosis has intact
methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU probable
methylmalonyl-CoA mutase from Mycobacterium tuberculosis
(750 aa), FASTA scores: opt: 258, E(): 3.2e-10, (73.35%
identity in 60 aa overlap). ORF predicted by GC plot."
/db_xref="EnsemblGenomes-Gn:Rv1489A"
/db_xref="EnsemblGenomes-Tr:CCP44250"
/db_xref="GOA:L7N6A8"
/db_xref="InterPro:IPR006099"
/db_xref="UniProtKB/TrEMBL:L7N6A8"
/protein_id="CCP44250.1"
/translation="MSVGEVEVLKVENSRVRAEQLAKLYELRSSRDRVRVDAALAELS
RAAAARGCAGTSGLGNNLMAPGPPHSLLGRDR"
gene 1679322..1680629
/locus_tag="Rv1490"
CDS 1679322..1680629
/codon_start=1
/transl_table=11
/locus_tag="Rv1490"
/product="Probable membrane protein"
/note="Rv1490, (MTCY277.12), len: 435 aa. Probable
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1490"
/db_xref="EnsemblGenomes-Tr:CCP44251"
/db_xref="GOA:P9WLX1"
/db_xref="UniProtKB/Swiss-Prot:P9WLX1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44251.1"
/translation="MSQCFAVKGIGGADQATLGSAEILVKYAQLADKRARVYVLVSTW
LVVWGIWHVYFVEAVFPNAILWLHYYAASYEFGFVRRGLGGELIRMLTGDHFFAGAYT
VLWTSITVWLIALAVVVWLILSTGNRSERRIMLALLVPVLPFAFSYAIYNPHPELFGM
TALVAFSIFLTRAHTSRTRVILSTLYGLTMAVLALIHEAIPLEFALGAVLAIIVLSKN
ATGATRRICTALAIGPGTVSVLLLAVVGRRDIADQLCAHIPHGMVENPWAVATTPQRV
LDYIFGRVESHADYHDWVCEHVTPWFNLDWITSAKLVAVVGFRALFGAFLLGLLFFVA
TTSMIRYVSAVPVRTFFAELRGNLALPVLASALLVPLFITAVDWTRWWVMITLDVAIV
YILYAIDRPEIEQPPSRRNVQVFVCVVLVLAVIPTGSANNIGR"
gene complement(1681208..1681966)
/locus_tag="Rv1491c"
CDS complement(1681208..1681966)
/codon_start=1
/transl_table=11
/locus_tag="Rv1491c"
/product="Conserved membrane protein"
/note="Rv1491c, (MTCY277.13c), len: 252 aa. Conserved
membrane protein. Similar to hypothetical proteins from
many organisms e.g. YDJZ_ECOLI|P76221 Escherichia coli
(235 aa), FASTA scores: opt: 223, E():6.7 e-07, (31.7%
identity in 145 aa overlap); AL133252|SCE46.15
Streptomyces coelicolor (249 aa), FASTA scores: opt: 378,
E(): 1.5e-17,(39.1% identity in 169 aa overlap). Also
similar to Mycobacterium tuberculosis hypothetical protein
Rv0625c."
/db_xref="EnsemblGenomes-Gn:Rv1491c"
/db_xref="EnsemblGenomes-Tr:CCP44252"
/db_xref="GOA:P9WFS3"
/db_xref="InterPro:IPR015414"
/db_xref="InterPro:IPR032816"
/db_xref="UniProtKB/Swiss-Prot:P9WFS3"
/protein_id="CCP44252.1"
/translation="MTAPAICNTTETVHGIATSLGAVARQASLPRIVGTVVGITVLVV
VALLVPVPTAVELRDWAKSLGAWFPLAFLLVHTVVTVPPFPRTAFTLAAGLLFGSVVG
VFIAVVGSTASAVIAMLLVRATGWQLNSLVRRRAINRLDERLRERGWLAILSLRLIPV
VPFAAINYAAGASGVRILSFAWATLAGLLPGTAAVVILGDAFAGSGSPLLILVSVCTG
ALGLTGLVYEIRNYRRQHRRMPGYDDPVREPALI"
gene 1682157..1684004
/gene="mutA"
/locus_tag="Rv1492"
CDS 1682157..1684004
/codon_start=1
/transl_table=11
/gene="mutA"
/locus_tag="Rv1492"
/product="Probable methylmalonyl-CoA mutase small subunit
MutA (MCM)"
/note="Rv1492, (MTCY277.14), len: 615 aa. Probable
mutA,Methylmalonyl-CoA mutase small-subunit, strong
similarity to e.g. MUTA_STRCM|Q05064 methylmalonyl-CoA
mutase beta-subunit from Streptomyces cinnamonensis (616
aa),FASTA scores: opt: 1512, E(): 0, (45.9% identity in
628 aa overlap). Contains PS00213 Lipocalin signature,
PS00544 Methylmalonyl-CoA mutase signature. Belongs to the
methylmalonyl-CoA mutase family."
/db_xref="EnsemblGenomes-Gn:Rv1492"
/db_xref="EnsemblGenomes-Tr:CCP44253"
/db_xref="GOA:P9WJK7"
/db_xref="InterPro:IPR004608"
/db_xref="InterPro:IPR006099"
/db_xref="InterPro:IPR016176"
/db_xref="InterPro:IPR036724"
/db_xref="UniProtKB/Swiss-Prot:P9WJK7"
/inference="protein motif:PROSITE:PS00213"
/inference="protein motif:PROSITE:PS00544"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44253.1"
/translation="MSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERL
LDTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGAT
ADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPAC
DVMLALVAQLDPGQRDTLSIDLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAI
TVDGPAFHNLGATAATELAATVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFM
TLAKMRALRQLWARVAEVVGDPGGGAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAG
VGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFV
EELTDRLARRAWQRFQAIEARGGFVEAHDFLAGQIAECAARRADDIAHRRLAITGVNE
YPNLGEPALPPGDPTSPVRRYAAGFEALRDRSDHHLARTGARPRVLLLPLGPLAEHNI
RTTFATNLLASGGIEAIDPGTVDAGTVGNAVADAGSPSVAVICGTDARYRDEVADIVQ
AARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKINVVQALSNLLTRLGA"
gene 1684005..1686257
/gene="mutB"
/locus_tag="Rv1493"
CDS 1684005..1686257
/codon_start=1
/transl_table=11
/gene="mutB"
/locus_tag="Rv1493"
/product="Probable methylmalonyl-CoA mutase large subunit
MutB (MCM)"
/note="Rv1493, (MTCY277.15), len: 750 aa. Probable
mutB,Methylmalonyl-CoA mutase large-subunit, strong
similarity to e.g. MUTB_STRCM|Q05065 methylmalonyl-CoA
mutase alpha-subunit from Streptomyces cinnamonensis (733
aa),FASTA scores: opt: 3562, E(): 0, (75.8% identity in
730 aa overlap). Contains PS00544 Methylmalonyl-CoA mutase
signature. Belongs to the methylmalonyl-CoA mutase
family."
/db_xref="EnsemblGenomes-Gn:Rv1493"
/db_xref="EnsemblGenomes-Tr:CCP44254"
/db_xref="GOA:P9WJK5"
/db_xref="InterPro:IPR006098"
/db_xref="InterPro:IPR006099"
/db_xref="InterPro:IPR006158"
/db_xref="InterPro:IPR006159"
/db_xref="InterPro:IPR016176"
/db_xref="InterPro:IPR036724"
/db_xref="PDB:1SE5"
/db_xref="UniProtKB/Swiss-Prot:P9WJK5"
/inference="protein motif:PROSITE:PS00544"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44254.1"
/translation="MTTKTPVIGSFAGVPLHSERAAQSPTEAAVHTHVAAAAAAHGYT
PEQLVWHTPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTI
RQYAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAID
SILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILK
EFMVRNTYIYPPKPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTL
ADGVDYIRAGLNAGLDIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQFAPK
SAKSLSLRTHSQTSGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPT
DFSARIARNTQLVLQQESGTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMA
QAISDGIPKLRIEEAAARTQARIDSGQQPVVGVNKYQVPEDHEIEVLKVENSRVRAEQ
LAKLQRLRAGRDEPAVRAALAELTRAAAEQGRAGADGLGNNLLALAIDAARAQATVGE
ISEALEKVYGRHRAEIRTISGVYRDEVGKAPNIAAATELVEKFAEADGRRPRILIAKM
GQDGHDRGQKVIATAFADIGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLT
LVPALRDALAQVGRPDIMIVVGGVIPPGDFDELYAAGATAIFPPGTVIADAAIDLLHR
LAERLGYTLD"
gene 1686271..1686573
/gene="mazE4"
/locus_tag="Rv1494"
CDS 1686271..1686573
/codon_start=1
/transl_table=11
/gene="mazE4"
/locus_tag="Rv1494"
/product="Possible antitoxin MazE4"
/note="Rv1494, (MTCY277.16), len: 100 aa. Possible
mazE4,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1495 (See Pandey and Gerdes, 2005; Zhu et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv1494"
/db_xref="EnsemblGenomes-Tr:CCP44255"
/db_xref="PDB:5XE3"
/db_xref="UniProtKB/Swiss-Prot:P9WJ91"
/protein_id="CCP44255.1"
/translation="MPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANA
AIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYESEAERSAARARRNARQQRSAQ"
gene 1686570..1686887
/gene="mazF4"
/gene_synonym="mt7"
/locus_tag="Rv1495"
CDS 1686570..1686887
/codon_start=1
/transl_table=11
/gene="mazF4"
/gene_synonym="mt7"
/locus_tag="Rv1495"
/product="Possible toxin MazF4"
/note="Rv1495, (MTCY277.17), len: 105 aa. Possible
mazF4,toxin, part of toxin-antitoxin (TA) operon with
Rv1494 (See Pandey and Gerdes, 2005; Zhu et al., 2006),
some similarity to Rv1942c|MTCY09F9.22 hypothetical
protein from Mycobacterium tuberculosis (109 aa) (0.7%
identity in 101 aa overlap) and Rv0659c, Rv1102c."
/db_xref="EnsemblGenomes-Gn:Rv1495"
/db_xref="EnsemblGenomes-Tr:CCP44256"
/db_xref="GOA:P9WII5"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="PDB:5XE2"
/db_xref="PDB:5XE3"
/db_xref="UniProtKB/Swiss-Prot:P9WII5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44256.1"
/translation="MNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTT
RRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDYLGEVTPATMNKINTALATALGL
PWP"
gene 1686884..1687888
/locus_tag="Rv1496"
CDS 1686884..1687888
/codon_start=1
/transl_table=11
/locus_tag="Rv1496"
/product="Possible transport system kinase"
/note="Rv1496, (MTCY277.18), len: 334 aa. Possible
transport system kinase. Equivalent to
NP_302220.1|NC_002677 putative kinase from Mycobacterium
leprae (327 aa). Highly similar to several transport
system kinases and NTPase transporters e.g.
P27254|ARGK_ECOLI|B2918 LAO/AO transport system kinase
from Escherichia coli K12 (331 aa) (see citation below);
NP_311815.1|NC_002695 ATPase component of two convergent
arginine transporter from Escherichia coli O157:H7 (331
aa); etc. Also similar to YPLE_CAUCR|P37895 hypothetical
34.6 kDa protein in Caulobacter crescentus (326 aa), FASTA
scores, opt: 1125, E(): 0, (55.7% identity in 316 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1496"
/db_xref="EnsemblGenomes-Tr:CCP44257"
/db_xref="GOA:P9WPZ1"
/db_xref="InterPro:IPR005129"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:3MD0"
/db_xref="PDB:3P32"
/db_xref="PDB:4GT1"
/db_xref="UniProtKB/Swiss-Prot:P9WPZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44257.1"
/translation="MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQA
QQLLLRLLPDSGNAHRVGITGVPGVGKSTAIEALGMHLIERGHRVAVLAVDPSSTRTG
GSILGDKTRMARLAVHPNAYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVG
VGQSEVAVANMVDTFVLLTLARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAA
RELSAAIRLIYPREALWRPPVLTMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRD
QQVDWTWQLVRDAVLDRVWSNPTVRKVRSELERRVRAGELTPALAAQQILEIANLTDR
"
gene 1687941..1689230
/gene="lipL"
/locus_tag="Rv1497"
CDS 1687941..1689230
/codon_start=1
/transl_table=11
/gene="lipL"
/locus_tag="Rv1497"
/product="Probable esterase LipL"
/note="Rv1497, (MTCY277.19), len: 429 aa. Probable
LipL,esterase, very similar to Mycobacterium tuberculosis
hypothetical esterases and penicillin binding proteins
e.g. Rv1923, Rv2463, Rv3775, etc. Also similar to
G151214|M68491 esterase estA from Pseudomonas sp (389 aa),
FASTA scores: opt: 604, E(): 1e-31, (34.4% identity in 389
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1497"
/db_xref="EnsemblGenomes-Tr:CCP44258"
/db_xref="GOA:P71778"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:P71778"
/protein_id="CCP44258.1"
/translation="MMVDTGVDHRAVSSHDGPDAGRRVFGAADPRFACVVRAFASMFP
GRRFGGGALAVYLDGQPVVDVWKGWADRAGWVPWSADSAPMVFSATKGMTATVIHRLA
DRGLIDYEAPVAEYWPAFGANGKATLTVRDVMRHQAGLSGLRGATQQDLLDHVVMEER
LAAAVPGRLLGKSAYHALTFGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRP
PADAPTRVAEIIMPQDIAANAVLTCAMRRLAHRFSGGFRSMYFPGAIAAVQGEAPLLD
AEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGLTRNRRQVLPDRNLLVP
LNFHLGYHGMPIGNVMPGFGHVGLGGSIGWTDPETGVAFALVHNRLLSPLVMTDHAGF
VGIYHLIRQAAAQARKRGYQPVTPFGAPYSEPGAAAG"
gene complement(1689303..1689920)
/locus_tag="Rv1498c"
CDS complement(1689303..1689920)
/codon_start=1
/transl_table=11
/locus_tag="Rv1498c"
/product="Probable methyltransferase"
/note="Rv1498c, (MTCY277.20c), len: 205 aa. Probable
methyltransferase. Similar to G2792343|AF040571
methyltransferase from amycolatopsis mediterranei (272
aa),FASTA scores: E(): 5.1e-11, (32.3% identity in 124 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A."
/db_xref="EnsemblGenomes-Gn:Rv1498c"
/db_xref="EnsemblGenomes-Tr:CCP44259"
/db_xref="GOA:P9WLW9"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WLW9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44259.1"
/translation="MLDVGCGSGRMALPLTGYLNSEGRYAGFDISQKAIAWCQEHITS
AHPNFQFEVSDIYNSLYNPKGKYQSLDFRFPYPDASFDVVFLTSVFTHMFPPDVEHYL
DEISRVLKPGGRCLCTYFLLNDESLAHIAEGKSAHNFQHEGPGYRTIHKKRPEEAIGL
PETFVRDVYGKFGLAVHEPLHYGSWSGREPRLSFQDIVIATKTAS"
gene complement(1690134..1690346)
/locus_tag="Rv1498A"
CDS complement(1690134..1690346)
/codon_start=1
/transl_table=11
/locus_tag="Rv1498A"
/product="Conserved protein"
/note="Rv1498A, len: 70 aa. Conserved protein, highly
similar to other hypothetical proteins e.g. from
Streptomyces coelicolor, Sinorhizobium meliloti and
Pseudomonas aeruginosa."
/db_xref="EnsemblGenomes-Gn:Rv1498A"
/db_xref="EnsemblGenomes-Tr:CCP44260"
/db_xref="InterPro:IPR009923"
/db_xref="InterPro:IPR025543"
/db_xref="InterPro:IPR036694"
/db_xref="UniProtKB/TrEMBL:I6XY36"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44260.1"
/translation="MSNHTYRVIEIVGTSPDGVDAAIQGGLARAAQTMRALDWFEVQS
IRGHLVDGAVAHFQVTMKVGFRLEDS"
gene 1690407..1690805
/locus_tag="Rv1499"
CDS 1690407..1690805
/codon_start=1
/transl_table=11
/locus_tag="Rv1499"
/product="Hypothetical protein"
/note="Rv1499, (MTCY277.21), len: 132 aa. Hypothetical
unknown protein; was initially longer but has been
shortened (-24 aa) owing to overlap with Rv1498A. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1499"
/db_xref="EnsemblGenomes-Tr:CCP44261"
/db_xref="UniProtKB/TrEMBL:P71780"
/protein_id="CCP44261.1"
/translation="MPSGEPSTAGHFEHLPRGSFGRILSVLNAAADHHPRELLVVGIA
TFDQKRPAVGVDEHDPGGAATPAVVINYESRSSAGGTIGHSTTSQVACCLYQQPKRPA
LRPTKAAATTAATTWIERVQNRRGRHSALV"
gene 1690850..1691878
/locus_tag="Rv1500"
CDS 1690850..1691878
/codon_start=1
/transl_table=11
/locus_tag="Rv1500"
/product="Probable glycosyltransferase"
/note="Rv1500, (MTCY277.22), len: 342 aa. Probable
glycosyltransferase, hydrophobic domain near C-terminus.
Some similarity to putative glycosyl-transferases from
Bacillus subtilis e.g. O34319|YKCC_BACSU (323 aa), opt:
490, E(): 6.1e-25, (28.85% identity in 312 aa overlap) and
to N-acetyl glucosamine transferases. Also similar to
G1001347 hypothetical 36.7 kDa protein (318 aa), FASTA
scores: opt: 523, E(): 7.2e-26, (30.6% identity in 307 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1500"
/db_xref="EnsemblGenomes-Tr:CCP44262"
/db_xref="GOA:P9WMX5"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WMX5"
/protein_id="CCP44262.1"
/translation="MRLSIVTTMYMSEPYVLEFYRRARAAADKITPDVEIIFVDDGSP
DAALQQAVSLLDSDPCVRVIQLSRNFGHHKAMMTGLAHATGDLVFLIDSDLEEDPALL
EPFYEKLISTGADVVFGCHARRPGGWLRNFGPKIHYRASALLCDPPLHENTLTVRLMT
ADYVRSLVQHQERELSIAGLWQITGFYQVPMSVNKAWKGTTTYTFRRKVATLVDNVTS
FSNKPLVFIFYLGAAIFIISSSAAGYLIIDRIFFRALQAGWASVIVSIWMLGGVTIFC
IGLVGIYVSKVFIETKQRPYTIIRRIYGSDLTTREPSSLKTAFPAAHLSNGKRVTSEP
EGLATGNR"
gene 1691890..1692711
/locus_tag="Rv1501"
CDS 1691890..1692711
/codon_start=1
/transl_table=11
/locus_tag="Rv1501"
/product="Conserved hypothetical protein"
/note="Rv1501, (MTCY277.23), len: 273 aa. Conserved
hypothetical protein, some similarity to
O06374|Rv3633|MTCY15C10.19C hypothetical protein from
Mycobacterium tuberculosis, FASTA scores: E():
3.9e-10,(27.5% identity in 280 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1501"
/db_xref="EnsemblGenomes-Tr:CCP44263"
/db_xref="InterPro:IPR008775"
/db_xref="UniProtKB/Swiss-Prot:P9WI91"
/protein_id="CCP44263.1"
/translation="MIPVKVENNTSLDQVQDALNCVGYAVVEDVLDEASLAATRDRMY
RVQERILTEIGKERLARAGELGVLRLMMKYDPHFFTFLEIPEVLSIVDRVLSETAILH
LQNGFILPSFPPFSTPDVFQNAFHQDFPRVLSGYIASVNIMFAIDPFTRDTGATLVVP
GSHQRIEKPDHTYLARNAVPVQCAAGSLFVFDSTLWHAAGRNTSGKDRLAINHQFTRS
FFKQQIDYVRALGDAVVLEQPARTQQLLGWYSRVVTNLDEYYQPPDKRLYRKGQG"
gene 1692924..1693823
/locus_tag="Rv1502"
CDS 1692924..1693823
/codon_start=1
/transl_table=11
/locus_tag="Rv1502"
/product="Hypothetical protein"
/note="Rv1502, (MTCY277.24), len: 299 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1502"
/db_xref="EnsemblGenomes-Tr:CCP44264"
/db_xref="InterPro:IPR023296"
/db_xref="UniProtKB/Swiss-Prot:P9WLW7"
/protein_id="CCP44264.1"
/translation="MAWRKLGRIFAPSGELDWSRSHAALPVPEWIEGDIFRIYFSGRD
GQNRSSIGSVIVDLAVGGKILDIPAEPILRPGARGMFDDCGVSIGSIVRAGDTRLLYY
TGWNLAVTVPWKNTIGVAISEAGAPFERWSTFPVVALDERDPFSLSYPWVIQDGGTYR
MWYGSNLGWGEGTDEIPHVIRYAQSRDGVHWEKQDRVHIDTSGSDNSAACRPYVVRDA
GVYRMWFCARGAKYRIYCATSEDGLTWRQLGKDEGIDVSPDSWDSDMIEYPCVFDHRG
QRFMLYSGDGYGRTGFGLAVLEN"
gene complement(1693996..>1694544)
/locus_tag="Rv1503c"
CDS complement(1693996..>1694544)
/codon_start=1
/transl_table=11
/locus_tag="Rv1503c"
/product="Conserved hypothetical protein"
/note="Rv1503c, (MTCY277.25c), len: 182 aa. Conserved
hypothetical protein, similar to C-terminal region of
P27833|RFFA_ECOLI lipopolysaccharide biosynthesis protein
from Escherichia coli (376 aa), FASTA scores: opt:
565,E(): 0, (49.4% identity in 170 aa overlap); Rv1503c
and Rv1504c are both similar to RFFA_ECOLI but are
separated by a stop codon, sequence appears to be correct
so possible pseudogene."
/db_xref="EnsemblGenomes-Gn:Rv1503c"
/db_xref="EnsemblGenomes-Tr:CCP44265"
/db_xref="GOA:L0T8G4"
/db_xref="InterPro:IPR000653"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/TrEMBL:L0T8G4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44265.1"
/translation="DFLLRAEILREKGTNRSRFLRNEVDKYTWQDKGSSYLPSELVAA
FLWAQFEEAERITRIRLDLWNRYHESFESLEQRGLLRRPIIPQGCSHNAHMYYVLLAP
SADREEVLARLTSEGIGAVFHYVPLHDSPAGRRYGRTNGNLTVTNDVASRLIRLPMWV
GLQEVDQSRVVEALTRILTLRA"
gene complement(1694545..1695144)
/locus_tag="Rv1504c"
CDS complement(1694545..1695144)
/codon_start=1
/transl_table=11
/locus_tag="Rv1504c"
/product="Conserved hypothetical protein"
/note="Rv1504c, (MTCY277.26c), len: 199 aa. Conserved
hypothetical protein, similar to N-terminal region of
P27833|RFFA_ECOLI lipopolysaccharide biosynthesis protein
from Escherichia coli (376 aa), FASTA scores: opt:
863,E(): 0, (68.0% identity in 194 aa overlap); Rv1503c
and Rv1504c are similar to RFFA_ECOLI but are separated by
a stop codon, sequence appears to be correct so possible
pseudogene."
/db_xref="EnsemblGenomes-Gn:Rv1504c"
/db_xref="EnsemblGenomes-Tr:CCP44266"
/db_xref="GOA:L0T6V0"
/db_xref="InterPro:IPR000653"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/TrEMBL:L0T6V0"
/protein_id="CCP44266.1"
/translation="MSDHKVPFNRPYMTGRELAYIAEAHSCGHLAGDGPFTRRSHAWL
EQQTGCRKALLTPSCTAALEMMALLLDIEEGDEVILPSYTFVSTANAFVLRGGVPVFV
DIRPDTLNIDETRIVDAITPRTKAIVPVHYAGVACEMDAIMKIATHHNLAVVEDAAQG
AMASYRGRALGSIGDLGALSFHETKNVISGEGGALLVNS"
gene complement(1695281..1695946)
/locus_tag="Rv1505c"
CDS complement(1695281..1695946)
/codon_start=1
/transl_table=11
/locus_tag="Rv1505c"
/product="Conserved hypothetical protein"
/note="Rv1505c, (MTCY277.27c), len: 221 aa. Conserved
hypothetical protein, some similarity to hypothetical
proteins and glycosylases e.g. P71063|O08181 hypothetical
22.5 kDa protein YVFD from Bacillus subtilis (216
aa),FASTA scores: E(): 2.4e-08, (25.5% identity in 196 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1505c"
/db_xref="EnsemblGenomes-Tr:CCP44267"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR011004"
/db_xref="InterPro:IPR020019"
/db_xref="UniProtKB/TrEMBL:P71784"
/protein_id="CCP44267.1"
/translation="MTKPLVIFGSGDIAQLAHYYFTRDSEYEVVAFTVDRDYASVSEF
CGLPLVAFDEVAQRFPPESHAMFVALAYAKLNGVRKEKYLAAKALGYELASYVSSHAT
VLNDGRIGENVFLLEDNTIQPFVSIGNNVTLWSGNHIGHHSTIHDHCFLASHIVVSGG
VVIEEQSFIGVNATLRDHITIGSRCVVGAGALLLGDADADGVYIGTKTERRPVPSTEL
RKI"
gene complement(1695943..1696443)
/locus_tag="Rv1506c"
CDS complement(1695943..1696443)
/codon_start=1
/transl_table=11
/locus_tag="Rv1506c"
/product="Hypothetical protein"
/note="Rv1506c, (MTCY277.28c), len: 166 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1506c"
/db_xref="EnsemblGenomes-Tr:CCP44268"
/db_xref="GOA:P71785"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/Swiss-Prot:P71785"
/protein_id="CCP44268.1"
/translation="MRIVNAADPFSINDLGCGYGALLDYLDARGFKTDYTGIDVSPEM
VRAAALRFEGRANADFICAARIDREADYSVASGIFNVRLKSLDTEWCAHIEATLDMLN
AASRRGFSFNCLTSYSDASKMRDDLYYADPCALFDLCKRRYSKSVALLHDYGLYEFTI
LVRKAS"
gene complement(1696727..1697422)
/locus_tag="Rv1507c"
CDS complement(1696727..1697422)
/codon_start=1
/transl_table=11
/locus_tag="Rv1507c"
/product="Conserved protein"
/note="Rv1507c, (MTCY277.29c), len: 231 aa. Conserved
protein. Similar to AJ007747|BBR007747_6 Hypothetical
protein BbLPS1.06 from Bordetella bronchiseptica cosmid
(239 aa), FASTA scores: opt: 362, E(): 1.3e-17, (30.8%
identity in 221 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1507c"
/db_xref="EnsemblGenomes-Tr:CCP44269"
/db_xref="GOA:P9WLW5"
/db_xref="InterPro:IPR014985"
/db_xref="UniProtKB/Swiss-Prot:P9WLW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44269.1"
/translation="MKKVAIVQSNYIPWRGYFDLIAFVDEFIIYDDMQYTKRDWRNRN
RIKTSQGLQWITVPVQVKGRFHQKIRETLIDGTDWAKAHWRALEFNYSAAAHFAEIAD
WLAPIYLEEQHTNLSLLNRRLLNAICSYLGISTRLANSWDYELADGKTERLANLCQQA
AATEYVSGPSARSYVDERVFDELSIRVTWFDYDGYRDYKQLWGGFEPAVSILDLLFNV
GAEAPDYLRYCRQ"
gene 1697356..1697859
/locus_tag="Rv1507A"
CDS 1697356..1697859
/codon_start=1
/transl_table=11
/locus_tag="Rv1507A"
/product="Hypothetical protein"
/note="Rv1507A, len: 167 aa. Hypothetical unknow protein.
Shows weak similarity with C-terminus of Q9XHQ7|CDA9
cytidine deaminase 9 from Arabidopsis thaliana (Mouse-ear
cress) (298 aa), FASTA scores: opt: 104, E(): 4.2, (33.6%
identity in 133 aa overlap), blastp scores: Score:
77,Identities: 39/133 (29%), Positives: 62/133 (46%)."
/db_xref="EnsemblGenomes-Gn:Rv1507A"
/db_xref="EnsemblGenomes-Tr:CCP44270"
/db_xref="UniProtKB/TrEMBL:L7N6B6"
/protein_id="CCP44270.1"
/translation="MQSGQNILAKVCNLIEQSRLSSTRCLQFRITNTSRPRQLRWSEF
KRFCDIFNMVLGKARMGRDPGRPVRDERRIVSCEIIASDHIGLAAARLLAKRYRGRSV
SGFVLMIKSASVHEIDSWSSPSVAMSIGVALCSYPHYAAARTSPPNRDWGEDTTRSRP
VTGLLAG"
gene complement(1698095..1699894)
/locus_tag="Rv1508c"
CDS complement(1698095..1699894)
/codon_start=1
/transl_table=11
/locus_tag="Rv1508c"
/product="Probable membrane protein"
/note="Rv1508c, (MTCY277.30c), len: 599 aa. Predicted to
be in the GT-C superfamily of glycosyltransferases (See
Liu and Mushegian, 2003). Probable membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1508c"
/db_xref="EnsemblGenomes-Tr:CCP44271"
/db_xref="GOA:P71787"
/db_xref="InterPro:IPR018584"
/db_xref="UniProtKB/TrEMBL:P71787"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44271.1"
/translation="MIPVMSARFTGFPLLPVALRHGITSGRGCGFILDVGAQRPFGND
VLLSVATRKIRSRLPGDRVGNHGALLPFRAEPRRIQMKRPPEVLRGAVTASRERLWAI
GSQSERTLMLGTILLASVISAATAYALSQWYAVDVFSTLLVVPGDCWLDWGMNIGRHC
FSDYAMVAAAGIQPNPADYLISLPADYQPTAVAAWAPARIPYAIFGLPSHWLGAPRLG
LICYLVALTMAVISPAIWAARGARGLERVVIFVTLGAAAIPAWGVIDRGNSTGFVVPI
ALAYFVALSRQRWGLATITVILAVLVKPQFVVLGVVLLAARQWRWAGIGITGVVVSNI
AAFLLWPRGFPGTIAQSIHGIIKFNSSFGGLRDPRNVSFGKALLLIPDSIKNYQSGKI
PEGFLTGPRTQIGFAVLVIVVVAVLALGRRIPPVMVGIVLLATATFSPADVAFYYLVF
VLPIAALVARDPNGPPGAGIFDQLAAHGDRRRAVGVCVSLAVALSIVNVAVPGQPFYV
PLYGQLGAKGVVGTTPLVFTTVTWAPFLWLVTCVVIIVSYARKPARPHDSHNGPTRES
DQDTAASTTSCLPNPVEESSPRGPGPICQNYTP"
gene 1699866..1700228
/locus_tag="Rv1508A"
CDS 1699866..1700228
/codon_start=1
/transl_table=11
/locus_tag="Rv1508A"
/product="Conserved hypothetical protein"
/note="Rv1508A, len: 120 aa. Conserved hypothetical
protein, highly similar to central part of glycosyl
transferases from various mycobacteria and eubacteria e.g.
P71790|MTCY277.33|Rv1511 Hypothetical protein from M.
tuberculosis (340 aa), FASTA scores: opt: 210, E(): 2.5
e-09, (42.9% identity in 105 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1508A"
/db_xref="EnsemblGenomes-Tr:CCP44272"
/db_xref="InterPro:IPR016040"
/db_xref="UniProtKB/TrEMBL:Q79FN0"
/protein_id="CCP44272.1"
/translation="MKRALITGITGPDGSYLAKLPLKGYVAAGSPAEVYFCWATRNYR
ELYGLLAVNSIWFNHESPRHGETFMTRNPAPYRGRQRGADRCADADAPAHPDRYQYWG
VPASVRGVIDRAMGVCVE"
gene 1700212..1701093
/locus_tag="Rv1509"
CDS 1700212..1701093
/codon_start=1
/transl_table=11
/locus_tag="Rv1509"
/product="Hypothetical protein"
/note="Rv1509, (MTCY277.31), len: 293 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1509"
/db_xref="EnsemblGenomes-Tr:CCP44273"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WLW3"
/protein_id="CCP44273.1"
/translation="MFALSNNLNRVNACMDGFLARIRSHVDAHAPELRSLFDTMAAEA
RFARDWLSEDLARLPVGAALLEVGGGVLLLSCQLAAEGFDITAIEPTGEGFGKFRQLG
DIVLELAAARPTIAPCKAEDFISEKRFDFAFSLNVMEHIDLPDEAVRRVSEVLKPGAS
YHFLCPNYVFPYEPHFNIPTFFTKELTCRVMRHRIEGNTGMDDPKGVWRSLNWITVPK
VKRFAAKDATLTLRFHRAMLVWMLERALTDKEFAGRRAQWMVAAIRSAVKLRVHHLAG
YVPATLQPIMDVRLTKR"
gene 1701295..1702593
/locus_tag="Rv1510"
CDS 1701295..1702593
/codon_start=1
/transl_table=11
/locus_tag="Rv1510"
/product="Conserved probable membrane protein"
/note="Rv1510, (MTCY277.32), len: 432 aa. Probable
membrane protein. Highly similar to Rv3630|MTCY15C10.22
(431 aa),FASTA scores: E(): 0, (70.8% identity in 424 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1510"
/db_xref="EnsemblGenomes-Tr:CCP44274"
/db_xref="GOA:P9WLW1"
/db_xref="UniProtKB/Swiss-Prot:P9WLW1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44274.1"
/translation="MYERRHERGMCDRAVEMTDVGATAAPTGPIARGSVARVGAATAL
AVACVYTVIYLAARDLPPACFSIFAVFWGALGIATGATHGLLQETTREVRWVRSTQIV
AGHRTHPLRVAGMIGTVAAVVIAGSSPLWSRQLFVEGRWLSVGLLSVGVAGFCAQATL
LGALAGVDRWTQYGSLMVTDAVIRLAVAAAAVVIGWGLAGYLWAATAGAVAWLLMLMA
SPTARSAASLLTPGGIATFVRGAAHSITAAGASAILVMGFPVLLKVTSDQLGAKGGAV
ILAVTLTRAPLLVPLSAMQGNLIAHFVDRRTQRLRALIAPALVVGGIGAVGMLAAGLT
GPWLLRVGFGPDYQTGGALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYLLGWVSATV
ASTLLLLLPMPLETRTVIALLFGPTVGIAIHVAALARRPD"
gene 1703074..1704096
/gene="gmdA"
/locus_tag="Rv1511"
CDS 1703074..1704096
/codon_start=1
/transl_table=11
/gene="gmdA"
/locus_tag="Rv1511"
/product="GDP-D-mannose dehydratase GmdA (GDP-mannose 4,6
dehydratase) (GMD)"
/note="Rv1511, (MTCY277.33), len: 340 aa. Probable
gmdA,GDP-D-mannose dehydratase, equivalent to
AF125999|AF125999_13 Mycobacterium avium enzyme (343
aa),FASTA scores: opt: 2085, E(): 0, (89.1% identity in
338 aa overlap); similar to G755218 pseudomonas aeruginosa
GDP-D-mannose dehydratase (GCA) (323 aa), FASTA scores:
opt: 1073, E(): 0, (51.9% identity in 320 aa overlap); and
to S74433 GDP-D-mannose dehydratase rfbD - Syn (362
aa),FASTA scores: opt: 1405, E(): 0, (63.9% identity in
327 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1511"
/db_xref="EnsemblGenomes-Tr:CCP44275"
/db_xref="GOA:P71790"
/db_xref="InterPro:IPR006368"
/db_xref="InterPro:IPR016040"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P71790"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44275.1"
/translation="MKRALITGITGQDGSYLAELLLAKGYEVHGLIRRASTFNTSRID
HLYVDPHQPGARLFLHYGDLIDGTRLVTLLSTIEPDEVYNLAAQSHVRVSFDEPVHTG
DTTGMGSMRLLEAVRLSRVHCRFYQASSSEMFGASPPPQNELTPFYPRSPYGAAKVYS
YWATRNYREAYGLFAVNGILFNHESPRRGETFVTRKITRAVARIKAGIQSEVYMGNLD
AVRDWGYAPEYVEGMWRMLQTDEPDDFVLATGRGFTVREFARAAFEHAGLDWQQYVKF
DQRYLRPTEVDSLIGDATKAAELLGWRASVHTDELARIMVDADMAALECEGKPWIDKP
MIAGRT"
gene 1704093..1705061
/gene="epiA"
/locus_tag="Rv1512"
CDS 1704093..1705061
/codon_start=1
/transl_table=11
/gene="epiA"
/locus_tag="Rv1512"
/product="Probable nucleotide-sugar epimerase EpiA"
/note="Rv1512, (MTCY277.34), len: 322 aa. Probable
epiA,nucleotide sugar epimerase, equivalent to
AJ223832|MAS223832_4 from Mycobacterium avium silvaticum
(339 aa), FASTA scores: opt: 1821, E(): 0, (84.6% identity
in 318 aa overlap); and similar to WCAG_ECOLI|P32055
colanic acid biosynthesis protein wcaG (321 aa), FASTA
scores: opt: 835, E(): 0, (53.5% identity in 316 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1512"
/db_xref="EnsemblGenomes-Tr:CCP44276"
/db_xref="GOA:P71791"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR028614"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P71791"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44276.1"
/translation="MNAHTSVGPLDRAARVYIAGHRGLVGSALLRTFAGAGFTNLLVR
SRAELDLTDRAATFDFVLESRPQVVIDAAARVGGILANDTYPADFLSENLQIQVNLLD
AAVAARVPRLLFLGSSCIYPKLAPQPIPESALLTGPLEPTNDAYAIAKIAGILAVQAV
RRQHGLPWISAMPTNLYGPGDNFSPSGSHLLPALIRRYDEAKASGAPNVTNWGTGTPR
RELLHVDDLASACLYLLEHFDGPTHVNVGTGIDHTIGEIAEMVASAVGYSGETRWDPS
KPDGTPRKLLDVSVLREAGWRPSIALRDGIEATVAWYREHAGTVRQ"
gene 1705058..1705789
/locus_tag="Rv1513"
CDS 1705058..1705789
/codon_start=1
/transl_table=11
/locus_tag="Rv1513"
/product="Conserved protein"
/note="Rv1513, (MTCY277.35), len: 243 aa. Conserved
protein, similar to hypothetical proteins from several
organisms e.g. AJ223833|MAP223833_3 from Mycobacterium
avium paratuberculosis (240 aa), FASTA scores: opt: 1053
E(): 0, (66.3% identity in 243 aa overlap); P74191|SLL1173
from Synechocystis (244 aa), FASTA scores: opt: 276, E():
1.1e-07, (32.2 % identity in 202 aa overlap). Also highly
similar to P95136|Q50460|MTCY349.33c|Rv2956 from
Mycobacterium tuberculosis (243 aa), (70.0% identity in
237 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1513"
/db_xref="EnsemblGenomes-Tr:CCP44277"
/db_xref="GOA:P71792"
/db_xref="InterPro:IPR006342"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:P71792"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44277.1"
/translation="MRLARRARNILRRNGIEVSRYFAELDWERNFLRQLQSHRVSAVL
DVGANSGQYARGLRGAGFAGRIVSFEPLPGPFAVLQRSASTDPLWECRRCALGDVDGT
ISINVAGNEGASSSVLPMLKRHQDAFPPANYVGAQRVPIHRLDSVAADVLRPNDIAFL
KIDVQGFEKQVIAGGDSTVHDRCVGMQLELSFQPLYEGGMLIREALDLVDSLGFTLSG
LQPGFTDPRNGRMLQADGIFFRGSD"
gene complement(1705807..1706595)
/locus_tag="Rv1514c"
CDS complement(1705807..1706595)
/codon_start=1
/transl_table=11
/locus_tag="Rv1514c"
/product="Conserved hypothetical protein"
/note="Rv1514c, (MTCY277.36c), len: 262 aa. Conserved
hypothetical protein. Similar to other hypothetical
proteins, and to WCAE_ECOLI|P71239 putative colanic acid
biosynthesis glycosyl transferase (248 aa), FASTA scores:
opt: 231, E(): 4.1e-08, (33.3% identity in 210 aa
overlap). Also similar to Mycobacterium tuberculosis
hypothetical glycosyltransferase, Rv2957."
/db_xref="EnsemblGenomes-Gn:Rv1514c"
/db_xref="EnsemblGenomes-Tr:CCP44278"
/db_xref="GOA:P9WMX9"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WMX9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44278.1"
/translation="MTSAPTVSVITISFNDLDGLQRTVKSVRAQRYRGRIEHIVIDGG
SGDDVVAYLSGCEPGFAYWQSEPDGGRYDAMNQGIAHASGDLLWFLHSADRFSGPDVV
AQAVEALSGKGPVSELWGFGMDRLVGLDRVRGPIPFSLRKFLAGKQVVPHQASFFGSS
LVAKIGGYDLDFGIAADQEFILRAALVCEPVTIRCVLCEFDTTGVGSHREPSAVFGDL
RRMGDLHRRYPFGGRRISHAYLRGREFYAYNSRFWENVFTRMSK"
gene complement(1706630..1707526)
/locus_tag="Rv1515c"
CDS complement(1706630..1707526)
/codon_start=1
/transl_table=11
/locus_tag="Rv1515c"
/product="Conserved hypothetical protein"
/note="Rv1515c, (MTCY277.37c), len: 298 aa. Conserved
hypothetical protein, similar to
P71805|MTCY02B12.11C|Rv1377c Hypothetical protein from
Mycobacterium tuberculosis, FASTA scores: E():
1.3e-05,(25.4% identity in 134 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1515c"
/db_xref="EnsemblGenomes-Tr:CCP44279"
/db_xref="GOA:P71794"
/db_xref="InterPro:IPR025714"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:P71794"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44279.1"
/translation="MSTNPGPAEGANQVMAQEHSAGAVQFTAHNVRLDDGTLTIPESS
RTLDESSWFISARGILETVFPGDKSHLRLADVGCLEGGYAVGFARMGFQVLGIEVREL
NMAACNYIKSKTNLPNLRFVHDNALNIANHGLFDTVFCCGLFYHLENPKQYLETLSSV
TNKLLILQTHFSIINRSDKWLRLPTTARQLTDRLLRRPAPVKFMLSAPTEHEGLPGRW
FTEFSDDRSFGQRDTAKWASWDNRRSFWIQREHLLQAIKDVGVDLVMEEYDNLEPSIA
ESLLGGSYAANLRGTFIGIKTR"
gene complement(1707529..1708539)
/locus_tag="Rv1516c"
CDS complement(1707529..1708539)
/codon_start=1
/transl_table=11
/locus_tag="Rv1516c"
/product="Probable sugar transferase"
/note="Rv1516c, (MTCY277.38c), len: 336 aa. Probable sugar
transferase, similar to AB010970|AB010970_6
glycosyltransferase from Streptococcus mutans (465
aa),FASTA scores: opt: 388, E(): 4.1e-18, (32.7% identity
in 214 aa overlap), slight similarity to SPSA_BACSU|P39621
spore coat polysaccharide biosynthesis (256 aa), fasta
scores: opt: 185, E(): 6.5e-05, (26.2% identity in 187 aa
overlap), strong similarity to Rv1520|MTCY19G5.08c
probable sugar transferase from Mycobacterium tuberculosis
(63.5% identity in 318 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1516c"
/db_xref="EnsemblGenomes-Tr:CCP44280"
/db_xref="GOA:P71795"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:P71795"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44280.1"
/translation="MSPQLCPKVSIVSTTHNQAGYARQAFDSFLDQQTDFPVEIIVAD
DASTDATPAIIREYAERYPHVFRPIFRTENLGLNGNLTGALSAARGEYVALCEADDYW
IDPLKLSKQVAFLDRHPKTTVCFHPVRVIWEDGHAKDSKFPPVRVRGNLSLDALILMN
FIQTNSAVYRRLERYDDIPADVMPLDWYLHVRHAVHGDIAMLPDTMAVYRRHAQGMWH
NQVVDPPKFWLTQGPGHAATFDAMLDLFPGDPAREELIAVMADWILRQIANVPGPEGR
AALQETIARHPRIAMLALQHRGATPARRLKTQWRKLAAATPSRRGLVDVWPSRLRRGC
RA"
gene 1708871..1709635
/locus_tag="Rv1517"
CDS 1708871..1709635
/codon_start=1
/transl_table=11
/locus_tag="Rv1517"
/product="Conserved hypothetical transmembrane protein"
/note="Rv1517, (MTCY277.39), len: 254 aa. Conserved
hypothetical transmembrane protein, similar to
G466802|LEPB1170_F2_64 from Mycobacterium leprae (230
aa),FASTA scores: opt: 282, E(): 2.2e-11, (34.1% identity
in 255 aa overlap). Also similar to Mycobacterium
tuberculosis Rv3821|MTCY409.09c (237 aa) (36.3% identity
in 256 aa overlap); and Rv3481c."
/db_xref="EnsemblGenomes-Gn:Rv1517"
/db_xref="EnsemblGenomes-Tr:CCP44281"
/db_xref="GOA:P71796"
/db_xref="InterPro:IPR021315"
/db_xref="UniProtKB/TrEMBL:P71796"
/protein_id="CCP44281.1"
/translation="MWTMVLLLGLGMAIDPARLGLAVVMLSRRRPMLNLFAFWVGGMV
AGVGIALAVLVFMRDVALAAIQGVVSAANEFREAVGILAGGRLHIVIGVIMLLLAARM
VARARAQVGVPVGPVGVADGGMSALALAQRPPGLVARLEVRTQQMLQGDVVWPAFVVG
VASSAPPFESVVALTVIMASGAEIGTQLGAFVVFTLLVLAVIEIPLVAYLAIPQQTQQ
VMLRFQDWVRSNRRQISLTILIGVGFLFLYQGVTSL"
gene 1709644..1710603
/locus_tag="Rv1518"
CDS 1709644..1710603
/codon_start=1
/transl_table=11
/locus_tag="Rv1518"
/product="Conserved hypothetical protein"
/note="Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa.
Conserved hypothetical protein, possibly glycosyl
transferase involved in exopolysaccharide
synthesis,similar to several hypothetical proteins and
glycosyl transferases from diverse organisms e.g.
P73996|D90911 from synecho cystis sp. (309 aa), Fasta
scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1518"
/db_xref="EnsemblGenomes-Tr:CCP44282"
/db_xref="GOA:P9WLV9"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WLV9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44282.1"
/translation="MVPGDASSVVSVNPAKPLISVCIPMYNNGATIERCLRSILEQEG
VEFEIVVVDDDSSDDCAAIAATMLRPGDRLLRNEPRLGLNRNHNKCLEVARGGLIQFV
HGDDRLLPGALQTLSRRFEDPSVGMAFAPRRVESDDIKWQQRYGRVHTRFRKLRDRNH
GPSLVLQMVLHGAKENWIGEPTAVMFRRQLALDAGGFRTDIYQLVDVDFWLRLMLRSA
VCFVPHELSVRRHTAATETTRVMATRRNVLDRQRILTWLIVDPLSPNSVRSAAALWWI
PAWLAMIVEVAVLGPQRRTHLKALAPAPFREFAHARRQLPMAD"
gene 1710733..1711002
/locus_tag="Rv1519"
CDS 1710733..1711002
/codon_start=1
/transl_table=11
/locus_tag="Rv1519"
/product="Conserved hypothetical protein"
/note="Rv1519, (MTCY19G5.09c), len: 89 aa. Conserved
hypothetical protein, high similarity to C-terminus of
Q50723|MTCY78.26|Rv3402c (412 aa) (58.1% identity in 74 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1519"
/db_xref="EnsemblGenomes-Tr:CCP44283"
/db_xref="GOA:P9WLV7"
/db_xref="InterPro:IPR000653"
/db_xref="InterPro:IPR015422"
/db_xref="UniProtKB/Swiss-Prot:P9WLV7"
/protein_id="CCP44283.1"
/translation="MRCGCLACDGVLCANGPGRPRRPALTCTAVATRTLHSLATNAEL
VESADLTVTEDICSRIVSLPVHDHMAIADVARVVAPFGEGLARGG"
gene 1711028..1712068
/locus_tag="Rv1520"
CDS 1711028..1712068
/codon_start=1
/transl_table=11
/locus_tag="Rv1520"
/product="Probable sugar transferase"
/note="Rv1520, (MTCY19G5.08c), len: 346 aa. Probable sugar
transferase, similar to several e.g. AB010970|AB010970_6
Streptococcus mutans glycosyltransferase (465 aa), FASTA
scores: opt: 381, E(): 1.2e-18, (31.7% identity in 240 aa
overlap); O34234|Y07786 sugar transferase from Vibrio
cholerae (337 aa), FASTA scores: opt: 214, E():
8.4e-05,(25.9% identity in 212 aa overlap). Also strongly
similar to Mycobacterium tuberculosis probable sugar
transferase Rv1516c. Alternative nucleotide at position
1711627 (C->T; Y200Y) has been observed."
/db_xref="EnsemblGenomes-Gn:Rv1520"
/db_xref="EnsemblGenomes-Tr:CCP44284"
/db_xref="GOA:P9WLV5"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WLV5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44284.1"
/translation="MSIVSISYNQEEYIREALDGFAAQRTEFPVEVIIADDASTDATP
RIIGEYAARYPQLFRPILRQTNIGVHANFKDVLSAARGEYLALCEGDDYWTDPLKLSK
QVKYLDRHPETTVCFHPVRVIYEDGAKDSEFPPLSWRRDLSVDALLARNFIQTNSVVY
RRQPSYDDIPANVMPIDWYLHVRHAVGGEIAMLPETMAVYRRHAHGIWHSAYTDRRKF
WETRGHGMAATLEAMLDLVHGHREREAIVGEVSAWVLREIGKTPGRQGRALLLKSIAD
HPRMTMLSLQHRWAQTPWRRFKRRLSTELSSLAALAYATRRRALEGRDGGYRETTSPP
TGRGRNVRGSHA"
gene 1712302..1714053
/gene="fadD25"
/locus_tag="Rv1521"
CDS 1712302..1714053
/codon_start=1
/transl_table=11
/gene="fadD25"
/locus_tag="Rv1521"
/product="Probable fatty-acid-AMP ligase FadD25
(fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)"
/note="Rv1521, (MTCY19G5.07), len: 583 aa. Probable
fadD25,fatty-acid-AMP synthetase, highly similar to many
e.g. P71495|U75685 acyl-CoA synthase from Mycobacterium
bovis (582 aa), FASTA scores: opt: 2486, E(): 0, (63.4%
identity in 584 aa overlap); NP_301232.1|NC_002677
acyl-CoA synthetase from Mycobacterium leprae (579 aa);
etc. Also highly similar to others from Mycobacterium
tuberculosis e.g. fadD24 (584 aa); fadD28 (580 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv1521"
/db_xref="EnsemblGenomes-Tr:CCP44285"
/db_xref="GOA:P9WQ45"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ45"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44285.1"
/translation="MSVVESSLPGVLRERASFQPNDKALTFIDYERSWDGVEETLTWS
QLYRRTLNLAAQLREHGSTGDRALILAPQSLDYVVSFIASLQAGIVAVPLSIPQGGAH
DERTVSVFADTAPAIVLTASSVVDNVVEYVQPQPGQNAPAVIEVDRLDLDARPSSGSR
SAAHGHPDILYLQYTSGSTRTPAGVMVSNKNLFANFEQIMTSYYGVYGKVAPPGSTVV
SWLPFYHDMGFVLGLILPILAGIPAVLTSPIGFLQRPARWIQMLASNTLAFTAAPNFA
FDLASRKTKDEDMEGLDLGGVHGILNGSERVQPVTLKRFIDRFAPFNLDPKAIRPSYG
MAEATVYVATRKAGQPPKIVQFDPQKLPDGQAERTESDGGTPLVSYGIVDTQLVRIVD
PDTGIERPAGTIGEIWVHGDNVAIGYWQKPEATERTFSATIVNPSEGTPAGPWLRTGD
SGFLSEGELFIMGRIKDLLIVYGRNHSPDDIEATIQTISPGRCAAIAVSEHGAEKLVA
IIELKKKDESDDEAAERLGFVKREVTSAISKSHGLSVADLVLVSPGSIPITTSGKIRR
AQCVELYRQDEFTRLDA"
gene complement(1714172..1717612)
/gene="mmpL12"
/locus_tag="Rv1522c"
CDS complement(1714172..1717612)
/codon_start=1
/transl_table=11
/gene="mmpL12"
/locus_tag="Rv1522c"
/product="Probable conserved transmembrane transport
protein MmpL12"
/note="Rv1522c, (MTCY19G5.06), len: 1146 aa. Probable
mmpL12, conserved transmembrane transport protein (see
Tekaia et al., 1999), member of RND superfamily. Strong
similarity to many Mycobacterial membrane proteins e.g.
Q49619|G466786 putative transport protein B1170_C1_181
from Mycobacterium leprae (1008 aa), FASTA scores: opt:
2418,E(): 0, (51.0% identity in 1006 aa overlap); etc.
Also highly similar to MmpL8|MTCY48.08c|Rv3823c probable
conserved transmembrane transport protein from
Mycobacterium tuberculosis, FASTA score: (34.3% identity
in 376 aa overlap); and some similarity to
MmpL10|MTCY20G9|Rv1183 probable conserved transmembrane
transport protein, FASTA score: (27.2% identity in 1011 aa
overlap). Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv1522c"
/db_xref="EnsemblGenomes-Tr:CCP44286"
/db_xref="GOA:P9WJT7"
/db_xref="InterPro:IPR000731"
/db_xref="InterPro:IPR004707"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJT7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44286.1"
/translation="MARHDEAKAGGLFDRIGNFVVRWPLIVIGCWIAVAAALTLLLPT
LQAQAAKREQAPLPPGAPSMVLQKEMSAAFQEKIETSALLLVLLTNENGLGPADEAVY
RKLIENLRADTQDKISVQDFLAVPEMKELLASKDNKAWNLPITFAGDAASPETQAAFK
RVAAIVKQTVAGTSLTVHLSGPIATVADLTELGEKDVRIIEIGTAVSVLIILILVYRN
LVTMLVPLATIGASVVTAQGTLSGLAEFGLAVNMQAIVFMSAVMIGAGTDYAVFLISR
YHDYVRHGEKSDMAVKKALMSIGKVITASAATVAVTFLAMVFTKLEVFSAVGPAIAVA
ITVSLLGAVTLLPAILTLTGRRGWIKPRRDLTSRMWRRSGVRIVRRSTIHLVGSLIVL
VALAGCTLLIRFNYDDLKTVPQHVESVKGYEAMNRHFPMNAMTPMVLFIKSPRDLRTP
GALADIEMMSREIAELPNIVMVRGLTRPNGEPLKETKVSFQAGEVGGKLDEATTLLEE
HGGELDQLTGGAHQLADALAQIRNEINGAVASSSGIVNTLQAMMDLMGGDKTIRQLEN
ASQYVGRMRALGDNLSGTVTDAEQIATWASPMVNALNSSPVCNSDPACRTSRAQLAAI
VQAQDDGLLRSIRALAVTLQQTQEYQTLARTVSTLDGQLKQVVSTLKAVDGLPTKLAQ
MQQGANALADGSAALAAGVQELVDQVKKMGSGLNEAADFLLGIKRDADKPSMAGFNIP
PQIFSRDEFKKGAQIFLSADGHAARYFVQSALNPATTEAMDQVNDILRVADSARPNTE
LEDATIGLAGVPTALRDIRDYYNSDMKFIVIATIVIVFLILVILLRALVAPIYLIGSV
LISYLSALGIGTLVFQLILGQEMHWSLPGLSFILLVAIGADYNMLLISRIRDESPHGI
RIGVIRTVGSTGGVITSAGLIFAASMFGLVGASINTMAQAGFTIGIGIVLDTFLVRTV
TVPALTTMIGRANWWPSELGRDPSTPPTKADRWLRRVKGHRRKAPIPAPKPPHTKVVR
NTNGHASKAATKSVPNGKPADLAEGNGEYLIDHLRRHSLPLFGYAAMPAYDVVDGVSK
PNGDGAHIGKEPVDHLLGHSLPLFGLAGLPSYDRWDDTSIGEPAVGHAGSKPDAKLST
"
gene 1717653..1718696
/locus_tag="Rv1523"
CDS 1717653..1718696
/codon_start=1
/transl_table=11
/locus_tag="Rv1523"
/product="Probable methyltransferase"
/note="Rv1523, (MTCY19G5.05c), len: 347 aa (start
uncertain). Probable methyltransferase, similar to
G560513|U0002O Mycobacterium leprae (270 aa), FASTA
scores: opt: 965, E(): 0, (60.3% identity in 247 aa
overlap). Also similar to many e.g. Q54303|X86780
methyltransferase RAPM from Streptomyces hygroscopicus
(317 aa), FASTA scores: opt: 323, E(): 1e-15, (41.2%
identity in 136 aa overlap). And similar to M.
tuberculosis hypothetical proteins Rv2952, Rv1405c,
Rv1403c, Rv0839."
/db_xref="EnsemblGenomes-Gn:Rv1523"
/db_xref="EnsemblGenomes-Tr:CCP44287"
/db_xref="GOA:Q50584"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:Q50584"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44287.1"
/translation="MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGR
DAASEQIARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVGKL
TTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLYHQTASQVDLT
GKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDLCRAKHRLPGLQFVQGDAQN
LPFPDESFDAVVNVEASHQYPDFRGFLAEVARVLRPGGHFLYTDSRRNPVVAEWEAAL
ADAPLRTISQRDIGAQAKRGLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRRG
GGFSYRIYLFAKD"
gene 1718726..1719970
/locus_tag="Rv1524"
CDS 1718726..1719970
/codon_start=1
/transl_table=11
/locus_tag="Rv1524"
/product="Probable glycosyltransferase"
/note="Rv1524, (MTCY19G5.04c), len: 414 aa. Probable
glycosyltransferase, similar to many e.g. P96559|U84349
glycosyltransferase GTFB from Amycolatopsis orientalis
(407 aa), FASTA scores: opt: 363, E(): 6.2e-23, (28.8%
identity in 430 aa overlap); also high similarity to
Rv1526c|MTCY19G5.02 Mycobacterium tuberculosis
hypothetical protein (58.7% identity in 416 aa overlap);
and AF143772|AF143772_15 glycosyltransferase gtfB from
Mycobacterium avium strain 215 (418 aa), FASTA scores:
opt: 1801, E(): 0, (65.2% identity in 417 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1524"
/db_xref="EnsemblGenomes-Tr:CCP44288"
/db_xref="GOA:P9WN07"
/db_xref="InterPro:IPR004276"
/db_xref="UniProtKB/Swiss-Prot:P9WN07"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44288.1"
/translation="MKFVVASYGTRGDIEPCAAVGLELQRRGHDVCLAVPPNLIGFVE
TAGLSAVAYGSRDSQEQLDEQFLHNAWKLQNPIKLLREAMAPVTEGWAELSAMLTPVA
AGADLLLTGQIYQEVVANVAEHHGIPLAALHFYPVRANGEIAFPARLPAPLVRSTITA
IDWLYWRMTKGVEDAQRRELGLPKASTPAPRRMAVRGSLEIQAYDALCFPGLAAEWGG
RRPFVGALTMESATDADDEVASWIAADTPPIYFGFGSMPIGSLADRVAMISAACAELG
ERALICSGPSDATGIPQFDHVKVVRVVSHAAVFPTCRAVVHHGGAGTTAAGLRAGIPT
LILWVTSDQPIWAAQIKQLKVGRGRRFSSATKESLIADLRTILAPDYVTRAREIASRM
TKPAASVTATADLLEDAARRAR"
gene 1720017..1720802
/gene="wbbL2"
/locus_tag="Rv1525"
CDS 1720017..1720802
/codon_start=1
/transl_table=11
/gene="wbbL2"
/locus_tag="Rv1525"
/product="Possible rhamnosyl transferase WbbL2"
/note="Rv1525, (MT1576, MTCY19G5.03c), len: 261 aa.
Possible wbbL2, rhamnosyl transferase (see citation
below),showing weak similarity to several rhamnosyl
transferases. Similar to AF105060|AF105060_1 Riftia
pachyptila endosymbiont (746 aa), FASTA scores: opt: 183,
E(): 0.00013, (35.2% identity in 105 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1525"
/db_xref="EnsemblGenomes-Tr:CCP44289"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WLV3"
/protein_id="CCP44289.1"
/translation="MYAPLVSLMITVPVFGQHEYTHALVADLEREGADYLIVDNRGDY
PRIGTERVSTPGENLGWAGGSELGFRLAFAEGYSHAMTLNNDTRVSKGFVAALLDSRL
PADAGMVGPMFDVGFPFAVADEKPDAESYVPRARYRKVPAVEGTALVMSRDCWDAVGG
MDLSTFGRYGWGLDLDLALRARKSGYGLYTTEMAYINHFGRKTANTHFGGHRYHWGAS
AAMIRGLRRTHGWPAAMGILREMGMAHHRKWHKSFPLTCPASC"
gene complement(1720780..1722060)
/locus_tag="Rv1526c"
CDS complement(1720780..1722060)
/codon_start=1
/transl_table=11
/locus_tag="Rv1526c"
/product="Probable glycosyltransferase"
/note="Rv1526c, (MTCY19G5.02), len: 426 aa. Probable
glycosyltransferase, highly similar to G467196 Protein
L518_C2_147 from Mycobacterium leprae (421 aa), FASTA
scores, opt: 1497, E(): 0, (55.0% identity in 424 aa
overlap); similar to G452504 rhamnosyltransferase (24.7%
identity in 433 aa overlap); and P96565|U84350
glycosyltransferase GTFE from Amycolatopsis orientalis
(408 aa), E(): 3.4e-24, (28.4% identity in 429 aa
overlap), also high similarity to Rv1524|MTCY19G5.04c
(58.7 % identity in 416 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1526c"
/db_xref="EnsemblGenomes-Tr:CCP44290"
/db_xref="GOA:P9WLV1"
/db_xref="InterPro:IPR004276"
/db_xref="UniProtKB/Swiss-Prot:P9WLV1"
/protein_id="CCP44290.1"
/translation="MKFVLAVHGTRGDVEPCAAVGVELRRRGHAVHMAVPPNLIEFVE
SAGLTGVAYGPDSDEQINTVAAFVRNLTRAQNPLNLARAVKELFVEGWAEMGTTLTTL
ADGADLVMTGQTYHGVAANVAEYYDIPAAALHHFPMQVNGQIAIPSIPTPATLVRATM
KVSWRLYAYVSKDADRAQRRELGLPPAPAPAVRRLAERGAPEIQAYDPVFFPGLAAEW
SDRRPFVGPLTMELHSEPNEELESWIAAGTPPIYFGFGSTPVQTPVQTLAMISDVCAQ
LGERALIYSPAANSTRIRHADHVKRVGLVNYSTILPKCRAVVHHGGAGTTAAGLRAGM
PTLILWDVADQPIWAGAVQRLKVGSAKRFTNITRGSLLKELRSILAPECAARAREIST
RMTRPTAAVTAAADLLEATARQTPGSTPSSSPGR"
gene complement(1722083..1728409)
/gene="pks5"
/locus_tag="Rv1527c"
CDS complement(1722083..1728409)
/codon_start=1
/transl_table=11
/gene="pks5"
/locus_tag="Rv1527c"
/product="Probable polyketide synthase Pks5"
/note="Rv1527c, (MTV045.01c-MTCY19G5.01), len: 2108 aa.
Probable pks5, polyketide synthase, highly similar to many
e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from
Mycobacterium bovis (2110 aa), FASTA scores: opt:
6270,E(): 0, (63.6% identity in 2126 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1527c"
/db_xref="EnsemblGenomes-Tr:CCP44291"
/db_xref="GOA:O53901"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:O53901"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44291.1"
/translation="MGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRLWEALLRGD
DLVTEIPADRWDIDEYYDPEPGVPGRTDCKWGAYLDNVGDFDPEFFGIGEKEAIAIDP
QHRLLLETSWEAMEHGGLTPNQMASRTGVFVGLVHTDYILVHADNQTFEGPYGNTGTN
ACFASGRVAYAMGLQGPAITVDTACSSGLTAIHLACRSLHDGESDIALAGGVYVMLEP
RRFASGSALGMLSATGRCHAFDVSADGFVSGEGCVMLALKRLPDALADGDRILAVIRG
TAANQDGHTVNIATPSRSAQVAAYREALDVAGVDPATVGMVEAHGPGTPVGDPIEYAS
LAEVYGNDGPCALASVKTNFGHTQSAAGALGLMKAVLALQHGVVPQNLHFTALPDKLA
AIETNLFVPQEITPWPGADQETPRRAAVSSYGMTGTNVHAIVEQAPVPAPESGAPGDT
PATPGIDGALLFALSASSQDALRQTAARLADWVDAQGPELAPADLAYTLARRRGHRPV
RTAVLAATTAELTEALREVATGEPPYPPAVGQDDRGPVWVFSGQGSQWAGMGADLLAT
EPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVTGIDRVQPTLFAMQVALAATMKSYG
VAPGAVIGHSLGESAAAVVAGALCLEDGVRVICRRSALMTRIAGAGAMASVELPAQQV
LSELMARGVNDAVVAVVASPQSTVIGGATQTVRDLVAAWEQRDVLAREVAVDVASHSP
QVDPILDELAEALAEISPLQPEIPYYSATSFDPREEPYCDAYYWVDNLRHTVRFAAAV
QAALEDGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMRREQPLPHGLRALAGDL
YAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDTTRRIAHANTVAVHPLLGSHVRL
PEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAYCEMALAAARAVLGEASEVRDI
RFEQMLLLDDETPIGVTATVEAPGVVPLTVETSHDGRYTRQLAAVLHVVREADDAPDQ
PPQKNIAELLASHPHKVDGAEVRQWLDKRGHRLGPAFAGLVDAYIAEGAGDTVLAEVN
LPGPLRSQVKAYGVHPVLLDACFQSVAAHPAVQGMADGGLLLPLGVRRLRSYGSARHA
RYCCTTVTACGVGVEADLDVLDEHGAVVLAVRGLQLGTGASQASERARVLGERLLSIE
WHERELPENSHAEPGAWLLISTCDATDLVAAQLTDALKVHDAQCTTMSWPQRADHAAQ
AARLRDQLGTGGFTGVFVLTAPQTGDPDAESPVRGGELVKHVVRIAREIPEITAQEPR
LYVLTHNAQAVLSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVARQL
LAASGEDETAWRNDQWYTARLCPAPLRPEERQTTVVDHAEAGMRLQIRTPGDLQTLEF
AAFDRVPPGPGEIEVAVTASSINFADVLVTFGRYQTLDGRQPQLGTDFAGVVSAVGPG
VSELKVGDRVGGMSPNGCWATFVTCDARLATRLPEGLTDAQAAAVTTASATAWYGLQD
LARIKAGDKVLIHSATGGVGQAAIAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDS
RSVEFAEQIRRDTAGYGVDIVLNSVTGAAQLAGLKLLALGGRFIEIGKRDIYSNTRLE
LLPFRRNLAFYGLDLGLMSVSHPAAVRELLSTVYRLTVEGVLPMPQSTHYPLAEAATA
IRVMGAAEHTGKLILDVPHAGRSSVVLPPEQARVFRSDGSYIITGGLGGLGLFLAEKM
ANAGAGRIVLSSRSQPSQKALETIELVRAIGSDVVVECGDIAQPDTADRLVTAATATG
LPLRGVLHAAAVVEDATLANITDELIERDWAPKAYGAWQLHRATADQPLDWFCSFSSA
AALVGSPGQGAYAAANSWLDTFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDAI
APEEGAYAFETLLRHNRAYSGYAPVIGSPWLTAFAQHSPFAEKFQSLGQNRSGTSKFL
AELVDLPREEWPDRLRRLLSKQVGLILRRTIDTDRLLSEYGLDSLSSQELRARVEAET
GIRISATEINTTVRGLADLMCDKLAADRDAPAPA"
gene complement(1728953..1729450)
/gene="papA4"
/locus_tag="Rv1528c"
CDS complement(1728953..1729450)
/codon_start=1
/transl_table=11
/gene="papA4"
/locus_tag="Rv1528c"
/product="Probable conserved polyketide synthase
associated protein PapA4"
/note="Rv1528c, (MTV045.02), len: 165 aa. Probable
papA4,conserved polyketide synthase (PKS) associated
protein; shows some similarity to C-terminal part of
hypothetical proteins from Mycobacterium tuberculosis and
Mycobacterium leprae e.g. Z97188|MTCY409_10 Mycobacterium
tuberculosis cosmid (468) (37.9% identity in 66 aa
overlap); or U00010_11 Mycobacterium leprae cosmid B1170
(35.7% identity in 84 aa overlap). Also similar to
Mycobacterium tuberculosis PKS-associated proteins Rv1182,
Rv3824c,Rv3820c."
/db_xref="EnsemblGenomes-Gn:Rv1528c"
/db_xref="EnsemblGenomes-Tr:CCP44292"
/db_xref="UniProtKB/TrEMBL:O53902"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44292.1"
/translation="MTQLPQPTWRWWQQRETEQVQSSHIDGEIVGALIPDLAVLHSED
ASRAAVGREKHRCSLDPLGGGFRSRRASMPAGALLLSAVIAIQLDRMNARVFGDGWIG
AQACMWVNKFHEESTVTALSPSSPIAQGSIARHPETMQSAYVRIAEGGSRDVAPAAQL
QRRRP"
gene 1729502..1731256
/gene="fadD24"
/locus_tag="Rv1529"
CDS 1729502..1731256
/codon_start=1
/transl_table=11
/gene="fadD24"
/locus_tag="Rv1529"
/product="Probable fatty-acid-AMP ligase FadD24
(fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)"
/note="Rv1529, (MTV045.03), len: 584 aa. Probable
fadD24,fatty-acid-AMP synthetase, highly similar to many
e.g. MBU75685_1|AAB52538.1|U75685 acyl-CoA synthase from
Mycobacterium bovis (582 aa), FASTA score: (65.6% identity
in 582 aa overlap); and many other fatty-acid-CoA
synthetases from Mycobacteria e.g. fadD25|MTCY19G5_7 from
Mycobacterium tuberculosis (583 aa), FASTA score: (68.7%
identity in 584 aa overlap); fadD28|MTCY24G1_8 from
Mycobacterium tuberculosis (580 aa), FASTA score: (66.0%
identity in 582 aa overlap);
NP_301232.1|NC_002677|U00010_6 from Mycobacterium leprae
(372 aa), FASTA score: (57.6% identity in 342 aa overlap);
FADD23|Rv3826|MTCY409.04c from Mycobacterium tuberculosis
(584 aa), FASTA score: (63.2% identity in 584 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv1529"
/db_xref="EnsemblGenomes-Tr:CCP44293"
/db_xref="GOA:O53903"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O53903"
/protein_id="CCP44293.1"
/translation="MVASSIPTALRERASVHPNGAAITYIDYEQDWAGVAETLTWSQL
YRRMLNVAEPLRHVGATGDRAVILAPQGIEYVVGFLGALQAGRIAVPLPVPHAGAHDE
RTISVLSDTSPAVILTTSGAVDDVRECAQPQPGQSAPSIVELDLLDLDSRQRSRSPGA
RPTGRDTPETAYLQYTSGSTRTPAGVMVSNKNVFANFEQIVADFFAPEGGVVPPDLTV
VSWLPLYHDMGLLLGAIMPILAGVPTVLTSPVGFLQRPARWIQLLARNGRTISAGPNF
AFELAVRKTSDDDMDGLDLAGVHTILNGSERVHPATLKRFAERFGRFNFAAAALRPAY
GMAEATVYIATRNVNEPPEIVDFESEKLPAGQAIRCPSGSGTPLVSYGVPRSQLVRIV
DPDTCIECPQGSVGEIWVQGGNVASGYWHKPEESKRTFGARIVTPSAGTPEAPWLRTG
DSGFVSGGELFIIGRIKDLLIVYGRNHAPDDIEATIQEITSGRCAAIAVPDHGTEKLV
AIIELKKRGDSDEDVADRLRIVKRDVAAAIFDSHGLSVADLVLVSPGSIPITTSGKIR
RAQCVQLYRRREFTRLDA"
gene 1731373..1732476
/gene="adh"
/locus_tag="Rv1530"
CDS 1731373..1732476
/codon_start=1
/transl_table=11
/gene="adh"
/locus_tag="Rv1530"
/product="Probable alcohol dehydrogenase Adh"
/note="Rv1530, (MTV045.04), len: 367 aa. Probable
adh,alcohol dehydrogenase, zinc-dependent, similar to many
e.g. AE0009|AE000958_23 Archaeoglobus fulgidus section 1
(402 aa), FASTA scores: opt: 423, E(): 1.8e-19, (31.7%
identity in 341 aa overlap). Contains PS00059
Zinc-containing alcohol dehydrogenases signature."
/db_xref="EnsemblGenomes-Gn:Rv1530"
/db_xref="EnsemblGenomes-Tr:CCP44294"
/db_xref="GOA:P9WQC3"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WQC3"
/inference="protein motif:PROSITE:PS00059"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44294.1"
/translation="MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCG
TDHEQYTGELAGGFAFVPGHETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCRQCAN
CRGGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVAT
LFNPLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDA
DRLALAAQFGADLAVDVAIDDPVAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPA
GTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAALDLLVSGRYPFASL
PRRCVRLEGAEDLLATMAGERDGVPPIHGVLTP"
gene 1732473..1733039
/locus_tag="Rv1531"
CDS 1732473..1733039
/codon_start=1
/transl_table=11
/locus_tag="Rv1531"
/product="Conserved protein"
/note="Rv1531, (MTV045.05), len: 188 aa. Conserved
protein,similar to Rv0464c|MTV038.08c (190 aa), FASTA
scores: E(): 4.8e-10, (30.9% identity in 175 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1531"
/db_xref="EnsemblGenomes-Tr:CCP44295"
/db_xref="GOA:O53905"
/db_xref="InterPro:IPR003779"
/db_xref="InterPro:IPR029032"
/db_xref="UniProtKB/TrEMBL:O53905"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44295.1"
/translation="MTTSRVPLLPVDEAKAAADEAGVPDYMAELSIFQVLLNHPRLAR
TFNDLLATMLWHGTLDSRLRELVIMRIGWLTDCDYEWTQHWRVASGLGVSADDLLGVR
DWQGYNGFGPAEQAVLAATDDVVREGAVSAQSWSACERELHCDKVVLIELVTVISAWR
MVASILHSLEVPLEDGVSSWPPDGLSPR"
gene complement(1733116..1733550)
/locus_tag="Rv1532c"
CDS complement(1733116..1733550)
/codon_start=1
/transl_table=11
/locus_tag="Rv1532c"
/product="Conserved hypothetical protein"
/note="Rv1532c, (MTCY07A7A.01c), len: 144 aa. Conserved
hypothetical protein, similar to P20378|YPHR_HALHA
Hypothetical 15.6 kDa protein from Halobacterium halobium
(151 aa), FASTA scores: opt: 152, E():4.5e-05, (30.1%
identity in 103 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1532c"
/db_xref="EnsemblGenomes-Tr:CCP44296"
/db_xref="InterPro:IPR003736"
/db_xref="InterPro:IPR006683"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:O06178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44296.1"
/translation="MSDPLTAQEQHKRRQAVRELMPRTPFIGGLGIVFERYEPDDVVI
RLPFRTDLTNDGTYFHGGVIASVMDTAGAAAAWSNHDFDRGTRAATVAMSIQYTGAAK
RCDLLCHARTARRRKELTFTEITATDPDGNIVAHAVQTYRIV"
gene 1733610..1734737
/locus_tag="Rv1533"
CDS 1733610..1734737
/codon_start=1
/transl_table=11
/locus_tag="Rv1533"
/product="Conserved protein"
/note="Rv1533, (MTCY07A7A.02), len: 375 aa. Conserved
protein. Similar to 2NPD_NEUCR|Q01284 2-nitropropane
dioxygenase precursor (378 aa), fasta scores: opt:
279,E(): 9.1e-11, (31.3% identity in 256 aa overlap). Also
similar to Mycobacterium tuberculosis hypothetical
proteins Rv1894c, Rv0021c, Rv3553, Rv2781c."
/db_xref="EnsemblGenomes-Gn:Rv1533"
/db_xref="EnsemblGenomes-Tr:CCP44297"
/db_xref="GOA:O06179"
/db_xref="InterPro:IPR004136"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/Swiss-Prot:O06179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44297.1"
/translation="MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSP
KRLESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLL
VRYGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAH
NHDVLVAALAGTAQHARRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTP
VLAAGGIARGRQIAAALALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSR
SLTGKPARMLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELA
TYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR"
gene 1734734..1735411
/locus_tag="Rv1534"
CDS 1734734..1735411
/codon_start=1
/transl_table=11
/locus_tag="Rv1534"
/product="Probable transcriptional regulator"
/note="Rv1534, (MTCY07A7A.03), len: 225 aa. Probable
transcriptional regulator, similar to YCDC_ECOLI|P75899
hypothetical transcriptional regulator from Escherichia
coli (212 aa), FASTA scores: opt: 166, E(): 9.8e-05,
(24.2% identity in 219 aa overlap). Contains PS01081
Bacterial regulatory proteins, TetR family signature and
helix turn helix motif (aa 41-62)."
/db_xref="EnsemblGenomes-Gn:Rv1534"
/db_xref="EnsemblGenomes-Tr:CCP44298"
/db_xref="GOA:O08377"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041669"
/db_xref="UniProtKB/TrEMBL:O08377"
/inference="protein motif:PROSITE:PS01081"
/protein_id="CCP44298.1"
/translation="MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVAD
IAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRALLQ
AAVQATFEFFETDKATVKLLFRDAYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGE
VVEAPSRMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGAR
GGRAART"
gene 1735976..1736212
/locus_tag="Rv1535"
CDS 1735976..1736212
/codon_start=1
/transl_table=11
/locus_tag="Rv1535"
/product="Unknown protein"
/note="Rv1535, (MTCY07A7A.04), len: 78 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1535"
/db_xref="EnsemblGenomes-Tr:CCP44299"
/db_xref="UniProtKB/TrEMBL:O06180"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44299.1"
/translation="MTAALHNDVVTVASAPKLRVVRDVPPAPASKKVARRLDAQPFGT
GGDPLVDGAARLLSIPLRHLYAALWRVGLLEVQA"
gene 1736519..1739644
/gene="ileS"
/locus_tag="Rv1536"
CDS 1736519..1739644
/codon_start=1
/transl_table=11
/gene="ileS"
/locus_tag="Rv1536"
/product="Isoleucyl-tRNA synthetase IleS"
/note="Rv1536, (MTCY48.29c-MTCCY07A7A.05), len: 1041 aa.
ileS, Isoleucyl-tRNA synthetase , similar to several e.g.
SYIC_YEAST P09436 isoleucyl-tRNA synthetase (1072
aa),FASTA scores: opt: 1447, E(): 0, (37.8% identity in
1072 aa overlap); contains PS00178 Aminoacyl-transfer RNA
synthetases class-I signature. Belongs to class-I
aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv1536"
/db_xref="EnsemblGenomes-Tr:CCP44300"
/db_xref="GOA:P9WFV3"
/db_xref="InterPro:IPR001412"
/db_xref="InterPro:IPR002300"
/db_xref="InterPro:IPR002301"
/db_xref="InterPro:IPR009008"
/db_xref="InterPro:IPR009080"
/db_xref="InterPro:IPR013155"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR023586"
/db_xref="InterPro:IPR033709"
/db_xref="UniProtKB/Swiss-Prot:P9WFV3"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44300.1"
/translation="MTDNAYPKLAGGAPDLPALELEVLDYWSRDDTFRASIARRDGAP
EYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVE
RQLGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAY
MESVIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRMDDDVYQSRQDPAVTVGF
KVVGGQPDNGLDGAYLLVWTTTPWTLPSNLAVAVSPDITYVQVQAGDRRFVLAEARLA
AYARELGEEPVVLGTYRGAELLGTRYLPPFAYFMDWPNAFQVLAGDFVTTDDGTGIVH
MAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSG
PAAVNGPVLIRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWY
PEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAYPRIDVYGSLDELERDFG
VRPANLHRPYIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPFENLDW
FQGHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSL
RNYPDVTEVFDRDGSDAMRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPLWNTYSFL
ALYAPKVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTN
WYVRRSRSRFWAEDADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRERSVHLTDW
PAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVENPQLLRPFV
DLIGDELNVKQVELTDAIDTYGRFELTVNARVAGPRLGKDVQAAIKAVKAGDGVINPD
GTLLAGPAVLTPDEYNSRLVAADPESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIR
ELQELRKSTGLDVSDRIRVVMSVPAEREDWARTHRDLIAGEILATDFEFADLADGVAI
GDGVRVSIEKT"
gene 1739856..1741247
/gene="dinX"
/gene_synonym="dinB1"
/locus_tag="Rv1537"
CDS 1739856..1741247
/codon_start=1
/transl_table=11
/gene="dinX"
/gene_synonym="dinB1"
/locus_tag="Rv1537"
/product="Probable DNA polymerase IV DinX (pol IV 1) (DNA
nucleotidyltransferase (DNA-directed))"
/note="Rv1537, (MTCY48.28c, MT1589), len: 463 aa. Probable
dinX (alternate gene name: dinB1), DNA polymerase IV.
Similar to umuC, mucB, samb, and impb (UV protection and
mutation) e.g. IMPB_SALTY|P18642 impb protein from
Salmonella typhimurium (424 aa), FASTA scores: opt:
386,E(): 1.7e-17, (27.5% identity in 415 aa overlap); etc.
Also similar to Mycobacterium tuberculosis Rv3056|dinP.
Belongs to the DNA polymerase type-Y family."
/db_xref="EnsemblGenomes-Gn:Rv1537"
/db_xref="EnsemblGenomes-Tr:CCP44301"
/db_xref="GOA:P9WNT3"
/db_xref="InterPro:IPR001126"
/db_xref="InterPro:IPR017961"
/db_xref="InterPro:IPR022880"
/db_xref="InterPro:IPR024728"
/db_xref="InterPro:IPR036775"
/db_xref="UniProtKB/Swiss-Prot:P9WNT3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44301.1"
/translation="MLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEA
RAYGARSAMPMHQARRLIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEA
FAEPPQLAGAVAEDVETFCERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIR
VVRHAEEQALLSGLPVRRLWGIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIG
PALHRLARGIDDRPVVERAEAKQISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRD
GRGARTITVKLKKSDMSTLTRSATMPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVG
FSGLSDIRQESLFADSDLTQETAAAHYVETPGAVVPAAHDATMWRVGDDVAHPELGHG
WVQGAGHGVVTVRFETRGSGPGSARTFPVDTGDISNASPLDSLDWPDYIGQLSVEGSA
GASAPTVDDVGDR"
gene complement(1741212..1742192)
/gene="ansA"
/locus_tag="Rv1538c"
CDS complement(1741212..1742192)
/codon_start=1
/transl_table=11
/gene="ansA"
/locus_tag="Rv1538c"
/product="Probable L-aparaginase AnsA"
/note="Rv1538c, (MTCY48.27), len: 326 aa. Probable
ansA,L-aparaginase, most similar to ASPG_BACLI|P30363
L-asparaginase (322 aa), FASTA scores: opt: 417, E():
8.8e-19, (30.9% identity in 314 aa overlap). Contains
PS00917 Asparaginase / glutaminase active site signature
2."
/db_xref="EnsemblGenomes-Gn:Rv1538c"
/db_xref="EnsemblGenomes-Tr:CCP44302"
/db_xref="GOA:P9WPX5"
/db_xref="InterPro:IPR004550"
/db_xref="InterPro:IPR006034"
/db_xref="InterPro:IPR020827"
/db_xref="InterPro:IPR027473"
/db_xref="InterPro:IPR027474"
/db_xref="InterPro:IPR027475"
/db_xref="InterPro:IPR036152"
/db_xref="InterPro:IPR037152"
/db_xref="InterPro:IPR040919"
/db_xref="UniProtKB/Swiss-Prot:P9WPX5"
/inference="protein motif:PROSITE:PS00917"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44302.1"
/translation="MGANHVRNDPIMARLTVITTGGTISTTAGPDGVLRPTHCGATLI
AGLDMDSDIEVVDLMALDSSKLTPADWDRIGAAVQEAFRGGADGVVITHGTDTLEETA
LWLDLTYAGSRPVVLTGAMLSADAPGADGPANLRDALAVAADPAARDLGVLVSFGGRV
LQPLGLHKVANPDLCGFAGESLGFTSGGVRLTRTKTRPYLGDLGAAVAPRVDIVAVYP
GSDAVAMDACVAAGARAVVLEALGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGA
RVGAGYGPGHDLVEAGAVMVPRLPPSQARVLLMAALAANSPVADVIDRWG"
gene 1742244..1742852
/gene="lspA"
/locus_tag="Rv1539"
CDS 1742244..1742852
/codon_start=1
/transl_table=11
/gene="lspA"
/locus_tag="Rv1539"
/product="Probable lipoprotein signal peptidase LspA"
/note="Rv1539, (MTCY48.26c), len: 202 aa. Probable
lspA,lipoprotein signal peptidase (see citation below),
similar to several e.g. LSPA_PSEFL|P17942 (170 aa), FASTA
scores: opt: 299, E(): 2.6e-12, (38.3% identity in 167 aa
overlap). Conserved in M. tuberculosis, M. leprae, M.
bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1539"
/db_xref="EnsemblGenomes-Tr:CCP44303"
/db_xref="GOA:P9WK99"
/db_xref="InterPro:IPR001872"
/db_xref="UniProtKB/Swiss-Prot:P9WK99"
/protein_id="CCP44303.1"
/translation="MPDEPTGSADPLTSTEEAGGAGEPNAPAPPRRLRMLLSVAVVVL
TLDIVTKVVAVQLLPPGQPVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVV
GIFWMGRRLVSPWWALGLGMILGGAMGNLVDRFFRAPGPLRGHVVDFLSVGWWPVFNV
ADPSVVGGAILLVILSIFGFDFDTVGRRHADGDTVGRRKADG"
gene 1742845..1743771
/locus_tag="Rv1540"
CDS 1742845..1743771
/codon_start=1
/transl_table=11
/locus_tag="Rv1540"
/product="Conserved hypothetical protein member of
yabO/yceC/yfiI family"
/note="Rv1540, (MTCY48.25c), len: 308 aa. Member of the
yabO/yceC/yfiI family of hypothetical proteins, similar to
P44445|YFII_HAEIN hypothetical protein HI0176 from
Haemophilus influenzae (324 aa), FASTA scores: opt:
437,E(): 1.2e-22, (33.2% identity in 322 aa overlap).
Equivalent to AL049478|MLCL458_13 hypothetical protein
from Mycobacterium leprae (308 aa), (89.3% identity in 307
aa overlap). Contains PS01129 hypothetical yabO/yceC/yfiI
family signature."
/db_xref="EnsemblGenomes-Gn:Rv1540"
/db_xref="EnsemblGenomes-Tr:CCP44304"
/db_xref="GOA:P9WHQ3"
/db_xref="InterPro:IPR002942"
/db_xref="InterPro:IPR006145"
/db_xref="InterPro:IPR006224"
/db_xref="InterPro:IPR006225"
/db_xref="InterPro:IPR020103"
/db_xref="InterPro:IPR036986"
/db_xref="UniProtKB/Swiss-Prot:P9WHQ3"
/inference="protein motif:PROSITE:PS01129"
/protein_id="CCP44304.1"
/translation="MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELN
GVPAGKSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAVAAH
ASVGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVAISERAYTVLKR
AFKYRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWKFAITKNGRHSLTHYDTLEA
FVAASLLDVHLETGRTHQIRVHFAALHHPCCGDLVYGADPKLAKRLGLDRQWLHARSL
AFAHPADGRRVEIVSPYPADLQHALKILRGEG"
gene complement(1743778..1744371)
/gene="lprI"
/locus_tag="Rv1541c"
CDS complement(1743778..1744371)
/codon_start=1
/transl_table=11
/gene="lprI"
/locus_tag="Rv1541c"
/product="Possible lipoprotein LprI"
/note="Rv1541c, (MTCY48.24), len: 197 aa. Possible
lipoprotein lprI, contains appropriately positioned
prokaryotic membrane lipoprotein lipid attachment site
(PS0013)."
/db_xref="EnsemblGenomes-Gn:Rv1541c"
/db_xref="EnsemblGenomes-Tr:CCP44305"
/db_xref="GOA:P9WK41"
/db_xref="InterPro:IPR009739"
/db_xref="InterPro:IPR018660"
/db_xref="InterPro:IPR036328"
/db_xref="UniProtKB/Swiss-Prot:P9WK41"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44305.1"
/translation="MRWIGVLVTALVLSACAANPPANTTSPTAGQSLDCTKPATIVQQ
LVCHDRQLTSLDHRLSTAYQQALAHRRSAALEAAQSSWTMLRDACAQDTDPRTCVQEA
YQTRLVQLAIADPATATPPVLTYRCPTQDGPLTAQFYNQFDPKTAVLNWKGDQVIVFV
ELSGSGARYGRQGIEYWEHQGEVRLDFHGATFVCRTS"
gene complement(1744426..1744836)
/gene="glbN"
/locus_tag="Rv1542c"
CDS complement(1744426..1744836)
/codon_start=1
/transl_table=11
/gene="glbN"
/locus_tag="Rv1542c"
/product="Hemoglobin GlbN"
/note="Rv1542c, (MTCY48.23), len: 136 aa. glbN,
hemoglobin. Belongs to the protozoan/cyanobacterial globin
family. Similar to myoglobins e.g. GLB_PARCA|P15160
myoglobin (hemoglobin) paramecium (116 aa), FASTA scores,
opt: 284,E(): 2.1e -13, (35.7% identity in 115 aa
overlap). Similar to Mycobacterium tuberculosis
hypothetical globin, Rv2470."
/db_xref="EnsemblGenomes-Gn:Rv1542c"
/db_xref="EnsemblGenomes-Tr:CCP44306"
/db_xref="GOA:P9WN25"
/db_xref="InterPro:IPR001486"
/db_xref="InterPro:IPR009050"
/db_xref="InterPro:IPR012292"
/db_xref="InterPro:IPR016339"
/db_xref="InterPro:IPR019795"
/db_xref="PDB:1IDR"
/db_xref="PDB:1RTE"
/db_xref="PDB:1S56"
/db_xref="PDB:1S61"
/db_xref="PDB:2GKM"
/db_xref="PDB:2GKN"
/db_xref="PDB:2GL3"
/db_xref="PDB:2GLN"
/db_xref="PDB:5AB8"
/db_xref="UniProtKB/Swiss-Prot:P9WN25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44306.1"
/translation="MGLLSRLRKREPISIYDKIGGHEAIEVVVEDFYVRVLADDQLSA
FFSGTNMSRLKGKQVEFFAAALGGPEPYTGAPMKQVHQGRGITMHHFSLVAGHLADAL
TAAGVPSETITEILGVIAPLAVDVTSGESTTAPV"
gene 1745064..1746089
/locus_tag="Rv1543"
CDS 1745064..1746089
/codon_start=1
/transl_table=11
/locus_tag="Rv1543"
/product="Possible fatty acyl-CoA reductase"
/note="Rv1543, (MTCY48.22c), len: 341 aa. Possible
fatty-acyl CoA reductase, highly similar to P94129|U77680
fatty acyl-CoA reductase ACR1 from Acinetobacter
calcoaceticus (295 aa), FASTA scores: opt: 899, E():
0,(48.5% identity in 293 aa overlap). Also highly similar
to acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty
acyl-CoA reductase from Mycobacterium tuberculosis (650
aa). Also highly similar to many oxidoreductases
short-chain family."
/db_xref="EnsemblGenomes-Gn:Rv1543"
/db_xref="EnsemblGenomes-Tr:CCP44307"
/db_xref="GOA:P9WGS1"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGS1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44307.1"
/translation="MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAVQG
RNLNDAVKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVARTLENLENVANDIRAIRG
NGGTAHVYPCDLSDMDAIAVMADQVLGDLGGVDILINNAGRSIRRSLELSYDRIHDYQ
RTMQLNYLGAVQLILKFIPGMRERHFGHIVNVSSVGVQTRAPRFGAYIASKAALDSLC
DALQAETVHDNVRFTTVHMALVRTPMISPTTIYDKFPTLTPDQAAGVITDAIVHRPRR
ASSPFGQFAAVADAVNPAVMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSETFVR
ATRGIHW"
gene 1746094..1746897
/locus_tag="Rv1544"
CDS 1746094..1746897
/codon_start=1
/transl_table=11
/locus_tag="Rv1544"
/product="Possible ketoacyl reductase"
/note="Rv1544, (MTCY48.21), len: 267 aa. Possible ketoacyl
reductase, highly similar to Z97179|MLCL383_26 putative
oxidoreductase from Mycobacterium leprae (268 aa), FASTA
score: (43.0% identity in 270 aa overlap). Also highly
similar to others e.g. T29125 ketoacyl reductase homolog
from Streptomyces coelicolor (276 aa);
NP_470957.1|NC_003212 protein similar to ketoacyl
reductases from Listeria innocua (253 aa);
HETN_ANASP|P37694 ketoacyl reductase from Anabaena sp.
strain PCC 7120 (287 aa), FASTA scores: opt: 379, E():
7.5e-18, (31.6% identity in 250 aa overlap); etc. And
highly similar to many oxidoreductases short-chain family.
Also highly similar to Rv2509 from Mycobacterium
tuberculosis (268 aa). Contains PS00061 Short-chain
alcohol dehydrogenase family signature. Belongs to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1544"
/db_xref="EnsemblGenomes-Tr:CCP44308"
/db_xref="GOA:Q10782"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:Q10782"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44308.1"
/translation="MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRE
RLDELADQLRQEHCVGVEVLPLDLADTQARAQLADRLRSDAIAGLCNSAGFGTSGRFW
ELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAGFQPIPYMAVYSAT
KAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIASAERFSIPLAQVSPHDVAEA
AIAGMLSGKRTVVPGIVPKFVSTSGRFAPRSLLLPAIRIGNRLRGGPSR"
gene 1746919..1747146
/locus_tag="Rv1545"
CDS 1746919..1747146
/codon_start=1
/transl_table=11
/locus_tag="Rv1545"
/product="Hypothetical protein"
/note="Rv1545, (MTCY48.20), len: 75 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1545"
/db_xref="EnsemblGenomes-Tr:CCP44309"
/db_xref="UniProtKB/Swiss-Prot:P9WLU9"
/protein_id="CCP44309.1"
/translation="MPNGVLGLGNPSRLAALYGLQLAHESQCCQMHNLPSAARQVTVA
CREEVGITTILAGRDECGVCDKTAGLDGAAP"
gene 1747195..1747626
/locus_tag="Rv1546"
CDS 1747195..1747626
/codon_start=1
/transl_table=11
/locus_tag="Rv1546"
/product="Conserved protein"
/note="Rv1546, (MTCY48.19c), len: 143 aa. Conserved
protein, similar to O05902|Rv0910|MTCY21C12.04
Hypothetical protein from Mycobacterium tuberculosis (144
aa), FASTA scores: E(): 5e-30, (37.3% identity in 142 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1546"
/db_xref="EnsemblGenomes-Tr:CCP44310"
/db_xref="GOA:P9WLU7"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/Swiss-Prot:P9WLU7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44310.1"
/translation="MASVELSADVPISPQDTWDHVSELSELGEWLVIHEGWRSELPDQ
LGEGVQIVGVARAMGMRNRVTWRVTKWDPPHEVAMTGSGKGGTKYGVTLTVRPTKGGS
ALGLRLELGGRALFGPLGSAAARAVKGDVEKSLKQFAELYG"
gene 1747694..1751248
/gene="dnaE1"
/locus_tag="Rv1547"
CDS 1747694..1751248
/codon_start=1
/transl_table=11
/gene="dnaE1"
/locus_tag="Rv1547"
/product="Probable DNA polymerase III (alpha chain) DnaE1
(DNA nucleotidyltransferase)"
/note="Rv1547, (MTCY48.18c), len: 1184 aa. Probable
dnaE1,DNA polymerase III, alpha chain (see citation
below),similar to many e.g. DP3A_ECOLI|P10443 dna
polymerase III,alpha chain (1160 aa), FASTA scores: opt:
1789, E(): 0,(36.5% identity in 1193 aa overlap). Also
similar to M. tuberculosis, DnaE2|Rv3370c. Belongs to DNA
polymerase type-C family, DNAE subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1547"
/db_xref="EnsemblGenomes-Tr:CCP44311"
/db_xref="GOA:P9WNT7"
/db_xref="InterPro:IPR003141"
/db_xref="InterPro:IPR004013"
/db_xref="InterPro:IPR004805"
/db_xref="InterPro:IPR011708"
/db_xref="InterPro:IPR016195"
/db_xref="InterPro:IPR029460"
/db_xref="InterPro:IPR040982"
/db_xref="InterPro:IPR041931"
/db_xref="PDB:5LEW"
/db_xref="UniProtKB/Swiss-Prot:P9WNT7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44311.1"
/translation="MSGSSAGSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVG
MTDHGNMFGASEFYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGS
GSYTHLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITTGCPS
GEVQTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRVRDGLLEIGRALN
IPPLATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWD
DEVPGACDSTLLIAERVQSYADVWTPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFP
AGPPDGYRERAAYEIDVICSKGFPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAY
ALGITDIDPIPHGLLFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQV
ITFGTIKTKAALKDSARIHYGQPGFAIADRITKALPPAIMAKDIPLSGITDPSHERYK
EAAEVRGLIETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPLWKRPQD
GAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDLESVPLDDKAT
YELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDVVAVIALYRPGPMGMNAHNDYADR
KNNRQAIKPIHPELEEPLREILAETYGLIVYQEQIMRIAQKVASYSLARADILRKAMG
KKKREVLEKEFEGFSDGMQANGFSPAAIKALWDTILPFADYAFNKSHAAGYGMVSYWT
AYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLPPDVNESGLNFASVGQD
IRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIKAGAF
DSLGHARKGLFLVHSDAVDSVLGTKKAEALGQFDLFGSNDDGTGTADPVFTIKVPDDE
WEDKHKLALEREMLGLYVSGHPLNGVAHLLAAQVDTAIPAILDGDVPNDAQVRVGGIL
ASVNRRVNKNGMPWASAQLEDLTGGIEVMFFPHTYSSYGADIVDDAVVLVNAKVAVRD
DRIALIANDLTVPDFSNAEVERPLAVSLPTRQCTFDKVSALKQVLARHPGTSQVHLRL
ISGDRITTLALDQSLRVTPSPALMGDLKELLGPGCLGS"
gene complement(1751297..1753333)
/gene="PPE21"
/locus_tag="Rv1548c"
CDS complement(1751297..1753333)
/codon_start=1
/transl_table=11
/gene="PPE21"
/locus_tag="Rv1548c"
/product="PPE family protein PPE21"
/note="Rv1548c, (MTCY48.17), len: 678 aa. PPE21, Member of
the Mycobacterium tuberculosis PPE family, similar to
several e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kDa
protein in hsp65 3' region (517 aa), FASTA scores:
opt:1142, E(): 0, (40.6% identity in 616 aa overlap); also
similar to MTCY31.06c (54.9% identity in 381 aa overlap).
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1548c"
/db_xref="EnsemblGenomes-Tr:CCP44312"
/db_xref="GOA:P9WI21"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44312.1"
/translation="MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAAS
FSAVTSQLATGSWQGPASAAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALA
ATVHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASA
VALSLTPFTPSPSAAATPGGAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPG
SANTGSVNLGNANIGDLNLGSGNIGSYNLGGGNTGDLNPDSGNTGTLNWGSGNIGSYN
LGGGNLGSYNLGSGNTGDTNFGGGNTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGD
TNFGSGNLGSGNIGFGNKGSHNIGFGNSGNNNIGFGLTGDNQIGFGALNSGSGNLGFG
NSGNGNIGFFNSGNNNIGMGNSGNGVGALSVEFGSSAERSSGFGNSGELSTGIGNSGQ
LSTGWFNSATTSTGWFNSGTTNTGWFNSGTTNTGIGNSGGNLVTGSMGLFNSGHTNTG
SFNAGSMNTGDFNSGNVNTGYFNSGNINTGFFNSGDLNTGLFNSVNQPVQNSGWLHTG
TNNSGYANAGTFNSGFDNNARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSV
PTITGTANISGFVNAGTSISGFFNFGSLMSGFANFDDEVSGYLNGDSRASGWIH"
gene 1753510..1754037
/gene="fadD11.1"
/gene_synonym="fadD11'"
/locus_tag="Rv1549"
CDS 1753510..1754037
/codon_start=1
/transl_table=11
/gene="fadD11.1"
/gene_synonym="fadD11'"
/locus_tag="Rv1549"
/product="Possible fatty-acid-CoA ligase FadD11.1
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv1549, (MTCY48.16c), len: 175 aa. Possible
fadD11.1, fatty-acid-CoA synthetase, similar to the
N-terminus of many fatty-acid CoA synthetases e.g.
NP_147860.1|NC_000854 long-chain-fatty-acid--CoA ligase
from Aeropyrum pernix (651 aa); P31685|4CL2_SOLTU
4-coumarate--CoA ligase 2 from Solanum tuberosum (Potato)
(545 aa), FASTA scores: opt: 168, E(): 4.4e-06, (30.4%
identity in 112 aa overlap); etc. Possible frameshift with
respect to next ORF Rv1550|MTCY48.15c but we can find no
sequence error to account for this. Note that previously
known as fadD11'."
/db_xref="EnsemblGenomes-Gn:Rv1549"
/db_xref="EnsemblGenomes-Tr:CCP44313"
/db_xref="GOA:P9WLU5"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WLU5"
/protein_id="CCP44313.1"
/translation="MVAAPCFRVLRLWTYAHRCDLGHTDPLSRRTEMTTTERPTTMCE
AFQRTAVMDPDAVALRTPGGNQTMTWRDYAAQVRRVAAGLAGLGVRRGDTVSLMMANR
IEFYPLDVGAQHVGATSFSVYNTLPAEQLTYVFDNAGTKVVICEQQYVDRVRASGVPI
EHIVCVDGAPPARSR"
gene 1753716..1755431
/gene="fadD11"
/locus_tag="Rv1550"
CDS 1753716..1755431
/codon_start=1
/transl_table=11
/gene="fadD11"
/locus_tag="Rv1550"
/product="Probable fatty-acid-CoA ligase FadD11
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv1550, (MTCY48.15c), len: 571 aa. Probable
fadD11,fatty-acid-CoA synthetase, similar, except in
N-terminus,to many e.g. SC6A5.39|T35430 probable
long-chain-fatty-acid--CoA ligase from Streptomyces
coelicolor (612 aa); NP_301672.1|NC_002677 putative
long-chain-fatty-acid-CoA ligase from Mycobacterium leprae
(600 aa); P44446|LCFH_HAEIN putative
long-chain-fatty-acid-CoA ligase from Haemophilus
influenzae (607 aa), FASTA scores: opt: 762, E():
2.3e-38,(34.4% identity in 436 aa overlap); etc. Contains
PS00455 Putative AMP-binding domain signature. Belongs to
the ATP-dependent AMP-binding enzyme family. Possible
frameshift with respect to previous ORF Rv1549|MTCY48.16c
but we can find no sequence error to account for this."
/db_xref="EnsemblGenomes-Gn:Rv1550"
/db_xref="EnsemblGenomes-Tr:CCP44314"
/db_xref="GOA:P9WQ53"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ53"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44314.1"
/translation="MARLRGAGAAGRCRPGRFGSSARRHGLADDGEPDRVLPARRRCS
ARRRHLVFGVQHPARRAADLRVRQRGDQGGHLRATVRRSRSRQRCAHRTHRLRRWRAP
GTLSLTDLYAAASGDFFDFESTWRAVQPEDIVTLIYTSGTTGNPKGVEMTHANLLFEG
YAIDEVLGIRFGDRVTSFLPSAHIADRMTGLYLQEMFGTQVTAVADARTIAAALPDVR
PTVWGAVPRVWEKLKAGIEFTVARETDEMKRQALAWAMSVAGKRANALLAGESMSDQL
VAEWAKADELVLSKLRERLGFGELRWALSGAAPIPKETLAFFAGIGIPIAEIWGMSEL
SCVATASHPRDGRLGTVGKLLPGLQGKIAEDGEYLVRGPLVMKGYRKEPAKTAEAIDS
DGWLHTGDVFDIDSDGYLRVVDRKKELIINAAGKNMSPANIENTILAACPMVGVMMAI
GDGRTYNTALLVFDADSLGPYAAQRGLDASPAALAADPEVIARIAAGVAEGNAKLSRV
EQIKRFRILPTLWEPGGDEITLTMKLKRRRIAAKYSAEIEELYASELRPQVYEPAAVP
STQPA"
gene 1755445..1757310
/gene="plsB1"
/locus_tag="Rv1551"
CDS 1755445..1757310
/codon_start=1
/transl_table=11
/gene="plsB1"
/locus_tag="Rv1551"
/product="Possible acyltransferase PlsB1"
/note="Rv1551, (MT1601, MTCY48.14c), len: 621 aa. Possible
plsB1, acyltransferase, similar to PLSB_HAEIN|P44857
glycerol-3-phosphate acyltransferase from Haemophilus
influenzae (810 aa), FASTA scores: opt: 434, E():
6.2e-22,(27.6% identity in 395 aa overlap). Also similar
to Rv2482c|plsB2 Probable glycerol-3-phosphate
acyltransferase from Mycobacterium tuberculosis (789 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1551"
/db_xref="EnsemblGenomes-Tr:CCP44315"
/db_xref="GOA:P9WI59"
/db_xref="InterPro:IPR002123"
/db_xref="InterPro:IPR022284"
/db_xref="InterPro:IPR028354"
/db_xref="InterPro:IPR041728"
/db_xref="UniProtKB/Swiss-Prot:P9WI59"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44315.1"
/translation="MTAREVGRIGLRKLLQRIGIVAESMTPLATDPVEVTQLLDARWY
DERLRALADELGRDPDSVRAEAAGYLREMAASLDERAVQAWRGFSRWLMRAYDVLVDE
DQITQLRKLDRKATLAFAFSHRSYLDGMLLPEAILANRLSPALTFGGANLNFFPMGAW
AKRTGAIFIRRQTKDIPVYRFVLRAYAAQLVQNHVNLTWSIEGGRTRTGKLRPPVFGI
LRYITDAVDEIDGPEVYLVPTSIVYDQLHEVEAMTTEAYGAVKRPEDLRFLVRLARQQ
GERLGRAYLDFGEPLPLRKRLQEMRADKSGTGSEIERIALDVEHRINRATPVTPTAVV
SLALLGADRSLSISEVLATVRPLASYIAARNWAVAGAADLTNRSTIRWTLHQMVASGV
VSVYDAGTEAVWGIGEDQHLVAAFYRNTAIHILVDRAVAELALLAAAETTTNGSVSPA
TVRDEALSLRDLLKFEFLFSGRAQFEKDLANEVLLIGSVVDTSKPAAAADVWRLLESA
DVLLAHLVLRPFLDAYHIVADRLAAHEDDSFDEEGFLAECLQVGKQWELQRNIASAES
RSMELFKTALRLARHRELVDGADATDIAKRRQQFADEIATATRRVNTIAELARRQ"
gene 1757681..1759432
/gene="frdA"
/locus_tag="Rv1552"
CDS 1757681..1759432
/codon_start=1
/transl_table=11
/gene="frdA"
/locus_tag="Rv1552"
/product="Probable fumarate reductase [flavoprotein
subunit] FrdA (fumarate dehydrogenase) (fumaric
hydrogenase)"
/note="Rv1552, (MTCY48.13c), len: 583 aa. Probable
frdA,fumarate reductase, flavoprotein subunit, highly
similar to others e.g. P00363|FRDA_ECOLI fumarate
reductase flavoprotein subunit from Escherichia coli
strain K12 (601 aa), FASTA scores: opt: 2102, E(): 0,
(54.7% identity in 585 aa overlap); NP_232284.1|NC_002505
fumarate reductase,flavoprotein subunit from Vibrio
cholerae (602 aa); frdA|NP_438995.1|NC_000907 fumarate
reductase, flavoprotein subunit from Haemophilus
influenzae (599 aa); etc. Contains PS00504 Fumarate
reductase / succinate dehydrogenase FAD-binding site. Note
that fumarate reductase forms part of an enzyme complex
containing four subunits: a flavoprotein (Rv1552|frdA), an
iron-sulfur (Rv1553|frdB),and two hydrophobic anchor
proteins (Rv1554|frdC and Rv1555|frdD)."
/db_xref="EnsemblGenomes-Gn:Rv1552"
/db_xref="EnsemblGenomes-Tr:CCP44316"
/db_xref="GOA:P9WN91"
/db_xref="InterPro:IPR003952"
/db_xref="InterPro:IPR003953"
/db_xref="InterPro:IPR005884"
/db_xref="InterPro:IPR014006"
/db_xref="InterPro:IPR015939"
/db_xref="InterPro:IPR027477"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR037099"
/db_xref="UniProtKB/Swiss-Prot:P9WN91"
/inference="protein motif:PROSITE:PS00504"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44316.1"
/translation="MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSH
TVSAEGGAAAVTGDDDSLDEHAHDTVSGGDWLCDQDAVEAFVAEAPKELVQLEHWGCP
WSRKPDGRVAVRPFGGMKKLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTL
LVDDGRVCGLVAIELATGRIETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFR
AGAPLKDMEFVQYHPTGLPFTGILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPR
LRSMELGPRDRLSQAFVHEHNKGRTVDTPYGPVVYLDLRHLGADLIDAKLPFVRELCR
DYQHIDPVVELVPVRPVVHYMMGGVHTDINGATTLPGLYAAGETACVSINGANRLGSN
SLPELLVFGARAGRAAADYAARHQKSDRGPSSAVRAQARTEALRLERELSRHGQGGER
IADIRADMQATLESAAGIYRDGPTLTKAVEEIRVLQERFATAGIDDHSRTFNTELTAL
LELSGMLDVALAIVESGLRREESRGAHQRTDFPNRDDEHFLAHTLVHRESDGTLRVGY
LPVTITRWPPGERVYGR"
gene 1759435..1760178
/gene="frdB"
/locus_tag="Rv1553"
CDS 1759435..1760178
/codon_start=1
/transl_table=11
/gene="frdB"
/locus_tag="Rv1553"
/product="Probable fumarate reductase [iron-sulfur
subunit] FrdB (fumarate dehydrogenase) (fumaric
hydrogenase)"
/note="Rv1553, (MTCY48.12c), len: 247 aa. Probable
frdB,fumarate reductase, iron-sulfur subunit, highly
similar to others e.g. P00364|FRDB_ECOLI fumarate
reductase iron-sulfur protein from Escherichia coli strain
K12 (243 aa), FASTA scores: opt: 846, E(): 0, (50.0%
identity in 242 aa overlap); P20921|FRDB_PROVU fumarate
reductase iron-sulfur protein from Proteus vulgaris (245
aa); G64097 fumarate reductase iron-sulfur protein from
Haemophilus influenzae (276 aa); etc. Contains PS00198
4Fe-4S ferredoxins, iron-sulfur binding region signature.
Note that fumarate reductase forms part of an enzyme
complex containing four subunits: a flavoprotein
(Rv1552|frdA), an iron-sulfur (Rv1553|frdB), and two
hydrophobic anchor proteins (Rv1554|frdC and
Rv1555|frdD)."
/db_xref="EnsemblGenomes-Gn:Rv1553"
/db_xref="EnsemblGenomes-Tr:CCP44317"
/db_xref="GOA:P9WN89"
/db_xref="InterPro:IPR004489"
/db_xref="InterPro:IPR009051"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR017900"
/db_xref="InterPro:IPR025192"
/db_xref="InterPro:IPR036010"
/db_xref="UniProtKB/Swiss-Prot:P9WN89"
/inference="protein motif:PROSITE:PS00198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44317.1"
/translation="MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKD
HLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDL
VVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACP
VYALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKG
VDPAGAIQRYKLTAATHALKKLLFPWGGG"
gene 1760175..1760555
/gene="frdC"
/locus_tag="Rv1554"
CDS 1760175..1760555
/codon_start=1
/transl_table=11
/gene="frdC"
/locus_tag="Rv1554"
/product="Probable fumarate reductase [membrane anchor
subunit] FrdC (fumarate dehydrogenase) (fumaric
hydrogenase)"
/note="Rv1554, (MTCY48.11c), len: 126 aa. Probable
frdC,fumarate reductase, membrane-anchor subunit, highly
similar to others e.g. P03805|FRDC_ECOLI fumarate
reductase 15 kDa hydrophobic protein from Escherichia coli
strain K12 (131 aa), FASTA scores, opt: 268, E(): 3.9e-10,
(31.1% identity in 122 aa overlap); NP_458780.1|NC_003198
fumarate reductase complex subunit C; membrane anchor
polypeptide from Salmonella enterica subsp. enterica
serovar Typhi (131 aa); P20923|FRDC_PROVU fumarate
reductase 15 kDa hydrophobic protein from Proteus vulgaris
(131 aa); etc. Note that fumarate reductase forms part of
an enzyme complex containing four subunits: a flavoprotein
(Rv1552|frdA), an iron-sulfur (Rv1553|frdB), and two
hydrophobic anchor proteins (Rv1554|frdC and
Rv1555|frdD)."
/db_xref="EnsemblGenomes-Gn:Rv1554"
/db_xref="EnsemblGenomes-Tr:CCP44318"
/db_xref="GOA:P9WNB7"
/db_xref="InterPro:IPR003510"
/db_xref="InterPro:IPR034804"
/db_xref="UniProtKB/Swiss-Prot:P9WNB7"
/protein_id="CCP44318.1"
/translation="MSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLMLVLR
AVGAGGNSYQRFLDFSANPVVVVLNVVALSFLLLHAVTWFGSAPRAMVIQVRGRRVPA
RAVLAGHYAAWLVVSVIVAWMVLS"
gene 1760552..1760929
/gene="frdD"
/locus_tag="Rv1555"
CDS 1760552..1760929
/codon_start=1
/transl_table=11
/gene="frdD"
/locus_tag="Rv1555"
/product="Probable fumarate reductase [membrane anchor
subunit] FrdD (fumarate dehydrogenase) (fumaric
hydrogenase)"
/note="Rv1555, (MTCY48.10c), len: 125 aa. Probable
frdD,fumarate reductase, membrane-anchor subunit, similar
to others e.g. P03806|FRDD_ECOLI fumarate reductase 13 kDa
hydrophobic protein from Escherichia coli strain K12 (119
aa), FASTA scores: opt: 212, E(): 4.4e-08, (36.8% identity
in 106 aa overlap); etc. Note that fumarate reductase
forms part of an enzyme complex containing four subunits:
a flavoprotein (Rv1552|frdA), an iron-sulfur
(Rv1553|frdB),and two hydrophobic anchor proteins
(Rv1554|frdC and Rv1555|frdD)."
/db_xref="EnsemblGenomes-Gn:Rv1555"
/db_xref="EnsemblGenomes-Tr:CCP44319"
/db_xref="GOA:P9WNB5"
/db_xref="InterPro:IPR003418"
/db_xref="InterPro:IPR034804"
/db_xref="UniProtKB/Swiss-Prot:P9WNB5"
/protein_id="CCP44319.1"
/translation="MTPSTSDARSRRRSAEPFLWLLFSAGGMVTALVAPVLLLLFGLA
FPLGWLDAPDHGHLLAMVRNPITKLVVLVLVVLALFHAAHRFRFVLDHGLQLGRFDRV
IALWCYGMAVLGSATAGWMLLTM"
gene 1760997..1761605
/locus_tag="Rv1556"
CDS 1760997..1761605
/codon_start=1
/transl_table=11
/locus_tag="Rv1556"
/product="Possible regulatory protein"
/note="Rv1556, (MTCY48.09c), len: 202 aa. Possible
regulatory protein, similar to X86780|SHGCPIR2|g987088
orfY, regulator of antibiotic transport complexes from
Streptomyces hygroscopicus (204 aa), FASTA score: opt:
251,E(): 1.7e-10, (33.8% identity in 201 aa overlap) and
others."
/db_xref="EnsemblGenomes-Gn:Rv1556"
/db_xref="EnsemblGenomes-Tr:CCP44320"
/db_xref="GOA:P9WMD1"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR011075"
/db_xref="InterPro:IPR023772"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/Swiss-Prot:P9WMD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44320.1"
/translation="MVGAVTQIADRPTDPSPWSPRETELLAVTLRLLQEHGYDRLTVD
AVAASARASKATVYRRWPSKAELVLAAFIEGIRQVAVPPNTGNLRDDLLRLGELICRE
VGQHASTIRAVLVEVSRNPALNDVLQHQFVDHRKALIQYILQQAVDRGEISSAAISDE
LWDLLPGYLIFRSIIPNRPPTQDTVQALVDDVILPSLTRSTG"
gene 1761744..1762937
/gene="mmpL6"
/locus_tag="Rv1557"
CDS 1761744..1762937
/codon_start=1
/transl_table=11
/gene="mmpL6"
/locus_tag="Rv1557"
/product="Probable conserved transmembrane transport
protein MmpL6"
/note="Rv1557, (MTCY48.08c), len: 397 aa. Probable
mmpL6,conserved transmembrane transport protein (see
citations below). Member of RND superfamily, with strong
similarity to C-terminal part of members of large
Mycobacterial membrane protein family belonging to RND
superfamily including: mmpL1, mmpL2, mmpL3, etc. Probably
truncated (see Brosch et al., 2002). Belongs to the MmpL
family."
/db_xref="EnsemblGenomes-Gn:Rv1557"
/db_xref="EnsemblGenomes-Tr:CCP44321"
/db_xref="GOA:P9WJU9"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJU9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44321.1"
/translation="MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLA
AIQPQLVALLPDEIASQQINRELALANYATMSGIYAQTAALIENAAAMGQAFDAAKND
DSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHE
AVKGTPMAGAGIYLAGTAATFKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAAL
VIVGTVALSLGASFGLSVLVWQHLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKE
EIGAGLNTGIIRAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDT
LVVRAFMTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGNDDPRTQ
VATHR"
gene 1762947..1763393
/locus_tag="Rv1558"
CDS 1762947..1763393
/codon_start=1
/transl_table=11
/locus_tag="Rv1558"
/product="Conserved protein"
/note="Rv1558, (MTCY48.07c), len: 148 aa. Conserved
protein, similar to other Mycobacterial tuberculosis
proteins e.g. P71854|MTCY03C7.09c|Rv3547 (151 aa), FASTA
scores opt: 330, E(): 9.1e-17, (39.7% identity in 151 aa
overlap); also Q11057|Rv1261c (149 aa), and O53328|Rv3178
(119 aa). Similar also to AF072709|AF072709_5 Hypothetical
protein with a new amplifiable element AUD4 from
Streptomyces lividans (149 aa), FASTA scores: opt:
695,E(): 0, (69.1% identity in 149 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1558"
/db_xref="EnsemblGenomes-Tr:CCP44322"
/db_xref="GOA:P9WP11"
/db_xref="InterPro:IPR004378"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/Swiss-Prot:P9WP11"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44322.1"
/translation="MPLSGEYAPSPLDWSREQADTYMKSGGTEGTQLQGKPVILLTTV
GAKTGKLRKTPLMRVEHDGQYAIVASLGGAPKNPVWYHNVVKNPRVELQDGTVTGDYD
AREVFGDEKAIWWQRAVAVWPDYASYQTKTDRQIPVFVLTPVRAGG"
gene 1763428..1764717
/gene="ilvA"
/locus_tag="Rv1559"
CDS 1763428..1764717
/codon_start=1
/transl_table=11
/gene="ilvA"
/locus_tag="Rv1559"
/product="Probable threonine dehydratase IlvA"
/note="Rv1559, (MTCY48.06c), len: 429 aa. Probable
ilvA,threonine dehydratase, biosynthetic protein, similar
to several e.g. THD1_CORGL|Q04513 threonine dehydratase
biosynthetic (436 aa), FASTA scores: opt: 1694, E():
0,(61.9% identity in 415 aa overlap). Contains PS00165
Serine/threonine dehydratases pyridoxal-phosphate
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1559"
/db_xref="EnsemblGenomes-Tr:CCP44323"
/db_xref="GOA:P9WG95"
/db_xref="InterPro:IPR000634"
/db_xref="InterPro:IPR001721"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR011820"
/db_xref="InterPro:IPR036052"
/db_xref="InterPro:IPR038110"
/db_xref="UniProtKB/Swiss-Prot:P9WG95"
/inference="protein motif:PROSITE:PS00165"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44323.1"
/translation="MSAELSQSPSSSPLFSLSGADIDRAAKRIAPVVTPTPLQPSDRL
SAITGATVYLKREDLQTVRSYKLRGAYNLLVQLSDEELAAGVVCSSAGNHAQGFAYAC
RCLGVHGRVYVPAKTPKQKRDRIRYHGGEFIDLIVGGSTYDLAAAAALEDVERTGATL
VPPFDDLRTIAGQGTIAVEVLGQLEDEPDLVVVPVGGGGCIAGITTYLAERTTNTAVL
GVEPAGAAAMMAALAAGEPVTLDHVDQFVDGAAVNRAGTLTYAALAAAGDMVSLTTVD
EGAVCTAMLDLYQNEGIIAEPAGALSVAGLLEADIEPGSTVVCLISGGNNDVSRYGEV
LERSLVHLGLKHYFLVDFPQEPGALRRFLDDVLGPNDDITLFEYVKRNNRETGEALVG
IELGSAADLDGLLARMRATDIHVEALEPGSPAYRYLL"
gene 1764755..1764973
/gene="vapB11"
/locus_tag="Rv1560"
CDS 1764755..1764973
/codon_start=1
/transl_table=11
/gene="vapB11"
/locus_tag="Rv1560"
/product="Possible antitoxin VapB11"
/note="Rv1560, (MTCY48.05c), len: 72 aa. Possible
vapB11,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1561 (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Part of a Mycobacterial tuberculosis family of proteins
e.g. Q10848|Rv2009|MTCY39.08c (80 aa), FASTA score: (54.4%
identity in 68 aa overlap); Q10799|Rv2871|MTCY274.02 (85
aa); O50456|Rv1241|MTV006.13 (86
aa),O06243|Rv2132|MTCY270.36C (76 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv1560"
/db_xref="EnsemblGenomes-Tr:CCP44324"
/db_xref="GOA:P9WLU3"
/db_xref="InterPro:IPR019239"
/db_xref="PDB:6A7V"
/db_xref="UniProtKB/Swiss-Prot:P9WLU3"
/protein_id="CCP44324.1"
/translation="MYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGS
PLSREFLLGLEGVGWEGDLDDLRSDRPD"
gene 1764979..1765383
/gene="vapC11"
/locus_tag="Rv1561"
CDS 1764979..1765383
/codon_start=1
/transl_table=11
/gene="vapC11"
/locus_tag="Rv1561"
/product="Possible toxin VapC11"
/note="Rv1561, (MTCY48.04c), len: 134 aa. Possible
vapC11,toxin, part of toxin-antitoxin (TA) operon with
Rv1560,contains PIN domain, (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to others from
Mycobacterium tuberculosis e.g. Q10847|Rv2010|MTCY39.07c
(132 aa), FASTA scores: (37.0% identity in 127 aa
overlap); and O06566|Rv1114|MTCY22G8.03 (124 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1561"
/db_xref="EnsemblGenomes-Tr:CCP44325"
/db_xref="GOA:P9WFA5"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="PDB:6A7V"
/db_xref="UniProtKB/Swiss-Prot:P9WFA5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44325.1"
/translation="MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAME
ILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAAGIYRAARRAGETVRSINDCLIA
ALAIRHGARIVHRDADFDVIARITNLQAASFR"
gene complement(1765400..1767142)
/gene="treZ"
/gene_synonym="glgZ"
/locus_tag="Rv1562c"
CDS complement(1765400..1767142)
/codon_start=1
/transl_table=11
/gene="treZ"
/gene_synonym="glgZ"
/locus_tag="Rv1562c"
/product="Maltooligosyltrehalose trehalohydrolase TreZ"
/note="Rv1562c, (MTCY48.03), len: 580 aa. TreZ (previously
called glgZ), Maltooligosyltrehalose
trehalohydrolase,confirmed biochemically (see citation
below). Similar to Q44316|D63343 TREZ maltooligosyl
trehalose trehalohydrolase from arthrobacter SP (598 aa),
FASTA scores: opt: 2071,E(): 0, (52.2% identity in 582 aa
overlap); also similar to 1,4-alpha-glucan branching
enzymes e.g. GLGB_BACST|P30538 (639 aa), FASTA scores:
opt: 313, E(): 3.8e-13, (27.5% identity in 462 aa
overlap). Also similar to Mycobacterium tuberculosis
proteins Rv1326c|glgB, and Rv1563c treY (previously
glgY)."
/db_xref="EnsemblGenomes-Gn:Rv1562c"
/db_xref="EnsemblGenomes-Tr:CCP44326"
/db_xref="GOA:P9WQ23"
/db_xref="InterPro:IPR006047"
/db_xref="InterPro:IPR012768"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR014756"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR022567"
/db_xref="UniProtKB/Swiss-Prot:P9WQ23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44326.1"
/translation="MPEFRVWAPKPALVRLDVNGAVHAMTRSADGWWHTTVAAPADAR
YGYLLDDDPTVLPDPRSARQPDGVHARSQRWEPPGQFGAARTDTGWPGRSVEGAVIYE
LHIGTFTTAGTFDAAIEKLDYLVDLGIDFVELMPVNSFAGTRGWGYDGVLWYSVHEPY
GGPDGLVRFIDACHARRLGVLIDAVFNHLGPSGNYLPRFGPYLSSASNPWGDGINIAG
ADSDEVRHYIIDCALRWMRDFHADGLRLDAVHALVDTTAVHVLEELANATRWLSGQLG
RPLSLIAETDRNDPRLITRPSHGGYGITAQWNDDIHHAIHTAVSGERQGYYADFGSLA
TLAYTLRNGYFHAGTYSSFRRRRHGRALDTSAIPATRLLAYTCTHDQVGNRALGDRPS
QYLTGGQLAIKAALTLGSPYTAMLFMGEEWGASSPFQFFCSHPEPELAHSTVAGRKEE
FAEHGWAADDIPDPQDPQTFQRCKLNWAEAGSGEHARLHRFYRDLIALRHNEADLADP
WLDHLMVDYDEQQRWVVMRRGQLMIACNLGAEPTCVPVSGELVLAWESPIIGDNSTEL
AAYSLAILRAAEPA"
gene complement(1767135..1769432)
/gene="treY"
/gene_synonym="glgY"
/locus_tag="Rv1563c"
CDS complement(1767135..1769432)
/codon_start=1
/transl_table=11
/gene="treY"
/gene_synonym="glgY"
/locus_tag="Rv1563c"
/product="Maltooligosyltrehalose synthase TreY"
/note="Rv1563c, (MTCY48.02), len: 765 aa. TreY (previously
called glgY), maltooligosyl trehalose synthase, confirmed
biochemically (see citation below). Strong similarity to
Q44315|63343 trey maltooligosyl trehalose synthase from
arthrobacter SP (775 aa), fasta scores: opt: 1953, E(): 0;
(46.0% identity in 789 aa overlap). Some similarity to
alpha-amylases and to MTCY48.03 (30.2% identity in 215 aa
overlap). May catalyse conversion of maltodextrins to
maltooligosyl trehaloses. Also similar to Mycobacterium
tuberculosis glgB (Rv1326c), treZ (Rv1562c)."
/db_xref="EnsemblGenomes-Gn:Rv1563c"
/db_xref="EnsemblGenomes-Tr:CCP44327"
/db_xref="GOA:P9WQ21"
/db_xref="InterPro:IPR006047"
/db_xref="InterPro:IPR012767"
/db_xref="InterPro:IPR017853"
/db_xref="UniProtKB/Swiss-Prot:P9WQ21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44327.1"
/translation="MAFPVISTYRVQMRGRSNGFGFTFADAENLLDYLDDLGVSHLYL
SPILTAVGGSTHGYDVTDPTTVSPELGGSDGLARLSAAARSRGMGLIVDIVPSHVGVG
KPEQNAWWWDVLKFGRSSAYAEFFDIDWELGDGRIILPLLGSDSDVANLRVDGDLLRL
GDLALPVAPGSGDGTGPAVHDRQHYRLVGWRHGLCGYRRFFSITSLAGLRQEDRAVFD
ASHAEVARWFTEGLVDGVRVDHLDGLSDPSGYLAQLRELLGPNAWIVVEKILAVDEAL
EPTLPVDGSTGYDVLREIGGVLVDPQGESPLTALVESAGVDYQEMPAMLADLKVHAAV
HTLASELRRLRRCIAAAAGADHPLLPAAVAALLRHIGRYRCDYPGQAAVLPCALAETH
STTPQLAPGLQLIAAAVARGGEPAVRLQQLCGAVSAKAVEDCMFYRDARLVSLNEVGG
EPRRFGVGAAEFHHRAATRARLWPRSMTTLSTHDTKRGEDVRARIGVLSQVPWLWAKF
IGHAQAIAPAPDAVTGQFLWQNVFGVWPVSGEVSAALRGRLHTYAEKAIREAAWHTSW
HNPNRAFEDDVHGWLDLVLDGPLASELTGLVAHLNSHAESDALAAKLLALTVPGVPDV
YQGSELWDDSLVDPDNRRPVDYGTRRVALKALQHPKIRVLAAALRLRRTHPESFLGGA
YHPVFAAGPAADHVVAFRRGDDILVAVTRWTVRLQQTGWDHTVLPLPDGSWTDALTGF
TASGHTPAVELFADLPVVLLVRDNA"
gene complement(1769436..1771601)
/gene="treX"
/gene_synonym="glgX"
/locus_tag="Rv1564c"
CDS complement(1769436..1771601)
/codon_start=1
/transl_table=11
/gene="treX"
/gene_synonym="glgX"
/locus_tag="Rv1564c"
/product="Probable maltooligosyltrehalose synthase TreX"
/note="Rv1564c, (MTCY48.01), len: 721 aa. Probable treX
(previously called glgX), Maltooligosyltrehalose synthase.
Strong similarity to D83245|g1890053 treX, glycogen
debranching enzyme (glgX) from Sulfolobus acidocaldarius
(713 aa), FASTA score: opt: 2396, E(): 0, (48.4% identity
in 709 aa overlap); similar to GLGX_HAEIN|P45178 glycogen
operon protein glgx (659 aa), FASTA scores: opt: 1512,
E(): 0, (42.3% identity in 645 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1564c"
/db_xref="EnsemblGenomes-Tr:CCP44328"
/db_xref="GOA:P9WQ25"
/db_xref="InterPro:IPR004193"
/db_xref="InterPro:IPR006047"
/db_xref="InterPro:IPR011837"
/db_xref="InterPro:IPR013780"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR014756"
/db_xref="InterPro:IPR017853"
/db_xref="UniProtKB/Swiss-Prot:P9WQ25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44328.1"
/translation="MSSNNAGESDGTGPALPTVWPGNAYPLGATYDGAGTNFSLFSEI
AEKVELCLIDEDGVESRIPLDEVDGYVWHAYLPNITPGQRYGFRVHGPFDPAAGHRCD
PSKLLLDPYGKSFHGDFTFGQALYSYDVNAVDPDSTPPMVDSLGHTMTSVVINPFFDW
AYDRSPRTPYHETVIYEAHVKGMTQTHPSIPPELRGTYAGLAHPVIIDHLNELNVTAV
ELMPVHQFLHDSRLLDLGLRNYWGYNTFGFFAPHHQYASTRQAGSAVAEFKTMVRSLH
EAGIEVILDVVYNHTAEGNHLGPTINFRGIDNTAYYRLMDHDLRFYKDFTGTGNSLNA
RHPHTLQLIMDSLRYWVIEMHVDGFRFDLASTLARELHDVDRLSAFFDLVQQDPVVSQ
VKLIAEPWDVGEGGYQVGNFPGLWTEWNGKYRDTVRDYWRGEPATLGEFASRLTGSSD
LYEATGRRPSASINFVTAHDGFTLNDLVSYNDKHNEANGENNRDGESYNRSWNCGVEG
PTDDPDILALRARQMRNMWATLMVSQGTPMIAHGDEIGRTQYGNNNVYCQDSELSWMD
WSLVDKNADLLAFARKATTLRKNHKVFRRRRFFEGEPIRSGDEVRDIAWLTPSGREMT
HEDWGRGFDRCVAVFLNGEAITAPDARGERVVDDSFLLCFNAHDHDVEFVMPHDGYAQ
QWTGELDTNDPVGDIDLTVTATDTFSVPARSLLVLRKTL"
gene complement(1771640..1773829)
/locus_tag="Rv1565c"
CDS complement(1771640..1773829)
/codon_start=1
/transl_table=11
/locus_tag="Rv1565c"
/product="Conserved hypothetical membrane protein"
/note="Rv1565c, (MTCY336.38), len: 729 aa. Conserved
hypothetical membrane protein, some similarity to O05402
hypothetical 72.2 kDa protein from Bacillus subtilis (634
aa), FASTA results: opt: 384, E(): 4.8e-17, (29.1%
identity in 378 aa overlap); and to Y392_HAEIN|P43993
hypothetical protein hi0392 from H. influenzae (245 aa),
FASTA results: opt: 265, E(): 5.5e-10, (28.3% identity in
247 aa overlap). C-terminal half equivalent to
AL049478|MLCL458_19 (274 aa) (78.5% identity in 274 aa
overlap). Also similar to Mycobacterium tuberculosis
hypothetical proteins Rv0111,Rv0228, Rv1254, Rv0517.
N-terminal half hydrophobic."
/db_xref="EnsemblGenomes-Gn:Rv1565c"
/db_xref="EnsemblGenomes-Tr:CCP44329"
/db_xref="GOA:O06625"
/db_xref="InterPro:IPR002656"
/db_xref="UniProtKB/TrEMBL:O06625"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44329.1"
/translation="MLTLSPPRPPALTPEPALPPVTMGTRTTGFYRHDLDGLRGVAIA
LVAVFHVWFGRVSGGVDVFLALSGFFFGGKILRAALNPDLSLSPIAEVIRLIRRLLPA
LVVVLAGCALLTIAIQPQTRWEAFANQSLASLGYYQNWELASTVSNYLRAGEAVSPLQ
HIWSMSVQGQFYLAFLLLVAGCAYLLRRLFRGPRAPYLRTMFVVLLSTLTLASFIYAI
VAHHAYQATAYYNTFARAWELLAGALVGAVVPHVRWPMWLRTAVATAALAAILSCGAL
IDGVKEFPGPWALVPVGATMLMILAGANRQGHPGTRDRLPLPNRLLATAPLVALGAMA
YSWYLWHWPLLIFWLSYTGHRHANFVEGAAVLLVSGLLAYLTTRLVEDPLRYRAPAGV
RSPAAVPPIPWRLRLRRPTIVLGSVVALLGVALTATSFTWREHVIVQRAAGKELSGLS
SRDYPGARALIDHVRVPKLRMRPTVLEVRHDLPTSTKDGCISDFVNPAIINCTYGDVD
APRTIALAGGSHAEHWLTALDLLGRMHHFKVVTYLKMGCPLSTEEVPLIMGNNAPYPQ
CHQWVQAAMAKLVADHPDYVFTTSTRPWNIKPGDVMPATYVGIWQTFADNNIPVLAMR
DTPWLVKDGQPFIPADCLAKGGNPQSCGIARSKVLVDRNPTLDFVARFPLLKPLDMSD
AICRTDTCRAVEGNVLVYRDSHHLTPTYMRTMTSELGRQIAANTDWW"
gene complement(1773928..1774620)
/locus_tag="Rv1566c"
CDS complement(1773928..1774620)
/codon_start=1
/transl_table=11
/locus_tag="Rv1566c"
/product="Possible Inv protein"
/note="Rv1566c, (MTCY336.37), len: 230 aa. Possible inv
protein, probably exported as has QQAPV repeats at
C-terminus. Similar to Q49634 inv protein from
Mycobacterium leprae (246 aa), FASTA scores: opt: 957,
E(): 0, (70.0% identity in 207 aa overlap); also to
putative invasins 1,2 (O07390, O07391) from Mycobacterium
avium. Slightly similar to C-terminus of P60_LISMO|P21171
Listeria invasion-associated protein p60 precursor. Also
similar to Mycobacterium tuberculosis p60 homologues
Rv1477, Rv1478,Rv0024, Rv2190c. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1566c"
/db_xref="EnsemblGenomes-Tr:CCP44330"
/db_xref="GOA:O06624"
/db_xref="InterPro:IPR000064"
/db_xref="InterPro:IPR038765"
/db_xref="PDB:4JXB"
/db_xref="PDB:4LJ1"
/db_xref="UniProtKB/TrEMBL:O06624"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44330.1"
/translation="MKRSMKSGSFAIGLAMMLAPMVAAPGLAAADPATRPVDYQQITD
VVIARGLSQRGVPFSWAGGGISGPTRGTGTGINTVGFDASGLIQYAYAGAGLKLPRSS
GQMYKVGQKVLPQQARKGDLIFYGPEGTQSVALYLGKGQMLEVGDVVQVSPVRTNGMT
PYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAP
VQPPPFGTARSR"
gene complement(1774860..1775144)
/locus_tag="Rv1567c"
CDS complement(1774860..1775144)
/codon_start=1
/transl_table=11
/locus_tag="Rv1567c"
/product="Probable hypothetical membrane protein"
/note="Rv1567c, (MTCY336.36), len: 94 aa. Probable
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1567c"
/db_xref="EnsemblGenomes-Tr:CCP44331"
/db_xref="GOA:O06623"
/db_xref="UniProtKB/TrEMBL:O06623"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44331.1"
/translation="MVTMTSWPSRLFAFTDNVCPPDACPLVPFGVNYYIYPVMWGGIG
AAIATAVIGPFVSMLKGWYMSFWPIISIAVITVTSIAGYAIAGFSERYWH"
gene 1775392..1776705
/gene="bioA"
/locus_tag="Rv1568"
CDS 1775392..1776705
/codon_start=1
/transl_table=11
/gene="bioA"
/locus_tag="Rv1568"
/product="Adenosylmethionine-8-amino-7-oxononanoate
aminotransferase BioA"
/note="Rv1568, (MTCY336.35c), len: 437 aa.
bioA,adenosylmethionine-8-amino-7-oxononanoate
aminotransferase , equivalent to a predicted homologous
protein from Mycobacterium smegmatis (see citation below).
Highly similar to BIOA_MYCLE|P4548 from Mycobacterium
leprae (436 aa), FASTA results: opt: 2534, E(): 0, (85.1%
identity in 436 aa overlap). Also similar to other
Mycobacterium tuberculosis proteins e.g. MTCY227.12c (449
aa), FASTA score: E(): 3.5e-16, (29.5% identity in 421 aa
overlap). Contains aminotransferases class-III
pyridoxal-phosphate attachment site (PS00600). Belongs to
class-III of pyridoxal-phosphate-dependent
aminotransferases."
/db_xref="EnsemblGenomes-Gn:Rv1568"
/db_xref="EnsemblGenomes-Tr:CCP44332"
/db_xref="GOA:P9WQ81"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR005815"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="PDB:3BV0"
/db_xref="PDB:3LV2"
/db_xref="PDB:3TFT"
/db_xref="PDB:3TFU"
/db_xref="PDB:4CXQ"
/db_xref="PDB:4CXR"
/db_xref="PDB:4MQP"
/db_xref="PDB:4MQQ"
/db_xref="PDB:4MQR"
/db_xref="PDB:4W1V"
/db_xref="PDB:4W1W"
/db_xref="PDB:4W1X"
/db_xref="PDB:4WYA"
/db_xref="PDB:4WYC"
/db_xref="PDB:4WYD"
/db_xref="PDB:4WYE"
/db_xref="PDB:4WYF"
/db_xref="PDB:4WYG"
/db_xref="PDB:4XEW"
/db_xref="PDB:4XJL"
/db_xref="PDB:4XJM"
/db_xref="PDB:4XJO"
/db_xref="PDB:4XJP"
/db_xref="UniProtKB/Swiss-Prot:P9WQ81"
/inference="protein motif:PROSITE:PS00600"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44332.1"
/translation="MAAATGGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGA
WLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAAR
LAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGD
TFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVV
VEPVVQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSP
DIMCVGKALTGGYLSLAATLCTADVAHTISAGAAGALMHGPTFMANPLACAVSVASVE
LLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAA
LDRGVWLRPFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP"
gene 1776702..1777862
/gene="bioF1"
/locus_tag="Rv1569"
CDS 1776702..1777862
/codon_start=1
/transl_table=11
/gene="bioF1"
/locus_tag="Rv1569"
/product="Probable 8-amino-7-oxononanoate synthase BioF1
(AONS) (8-amino-7-ketopelargonate synthase)
(7-keto-8-amino-pelargonic acid synthetase) (7-KAP
synthetase) (L-alanine--pimelyl CoA ligase)"
/note="Rv1569, (MTCY336.34c), len: 386 aa. Probable
bioF1,8-amino-7-oxononanoate synthase, highly similar to
BIOF_MYCLE|P45487 from Mycobacterium leprae (385 aa),
FASTA results: opt: 1971, E(): 0, (80.1% identity in 381
aa overlap). Also similar to BIOF2|Rv0032|MTCY10H4.32
possible 8-amino-7-oxononanoate synthase from
Mycobacterium tuberculosis (771 aa), FASTA score: E():
5.5e-29, (37.4% identity in 393 aa overlap). Contains
aminotransferases class-II pyridoxal-phosphate attachment
site (PS00599). Belongs to class-II of
pyridoxal-phosphate-dependent aminotransferases."
/db_xref="EnsemblGenomes-Gn:Rv1569"
/db_xref="EnsemblGenomes-Tr:CCP44333"
/db_xref="GOA:P9WQ87"
/db_xref="InterPro:IPR001917"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WQ87"
/inference="protein motif:PROSITE:PS00599"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44333.1"
/translation="MKAATQARIDDSPLAWLDAVQRQRHEAGLRRCLRPRPAVATELD
LASNDYLGLSRHPAVIDGGVQALRIWGAGATGSRLVTGDTKLHQQFEAELAEFVGAAA
GLLFSSGYTANLGAVVGLSGPGSLLVSDARSHASLVDACRLSRARVVVTPHRDVDAVD
AALRSRDEQRAVVVTDSVFSADGSLAPVRELLEVCRRHGALLLVDEAHGLGVRGGGRG
LLYELGLAGAPDVVMTTTLSKALGSQGGVVLGPTPVRAHLIDAARPFIFDTGLAPAAV
GAARAALRVLQAEPWRPQAVLNHAGELARMCGVAAVPDSAMVSVILGEPESAVAAAAA
CLDAGVKVGCFRPPTVPAGTSRLRLTARASLNAGELELARRVLTDVLAVARR"
gene 1777859..1778539
/gene="bioD"
/locus_tag="Rv1570"
CDS 1777859..1778539
/codon_start=1
/transl_table=11
/gene="bioD"
/locus_tag="Rv1570"
/product="Dethiobiotin synthetase BioD"
/note="Rv1570, (MTCY336.33c), len: 226 aa.
bioD,dethiobiotin synthetase. Similar to many e.g.
BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa),
FASTA results: opt: 1059, E(): 0, (74.8% identity in 222
aa overlap). Belongs to the dethiobiotin synthetase
family."
/db_xref="EnsemblGenomes-Gn:Rv1570"
/db_xref="EnsemblGenomes-Tr:CCP44334"
/db_xref="GOA:P9WPQ5"
/db_xref="InterPro:IPR004472"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:3FGN"
/db_xref="PDB:3FMF"
/db_xref="PDB:3FMI"
/db_xref="PDB:3FPA"
/db_xref="PDB:4WOP"
/db_xref="PDB:6CVE"
/db_xref="PDB:6CVF"
/db_xref="PDB:6CVU"
/db_xref="PDB:6CVV"
/db_xref="PDB:6CZB"
/db_xref="PDB:6CZC"
/db_xref="PDB:6CZD"
/db_xref="PDB:6CZE"
/db_xref="PDB:6E05"
/db_xref="PDB:6E06"
/db_xref="UniProtKB/Swiss-Prot:P9WPQ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44334.1"
/translation="MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTA
RGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPG
RLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQ
VSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDR
NWVAGLVG"
gene 1778539..1779048
/locus_tag="Rv1571"
CDS 1778539..1779048
/codon_start=1
/transl_table=11
/locus_tag="Rv1571"
/product="Conserved protein"
/note="Rv1571, (MTCY336.32c), len: 169 aa. Conserved
protein, similar at N-terminal region to
Q49625|LEPB1170_C3_227 hypothetical protein from
Mycobacterium leprae (104 aa), FASTA results: opt:
473,E(): 3.9e-24, (74.5% identity in 102 aa overlap).
Identical to O06619|AF041819|AF041819_6 Mycobacterium
bovis BCG (169 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1571"
/db_xref="EnsemblGenomes-Tr:CCP44335"
/db_xref="InterPro:IPR009097"
/db_xref="UniProtKB/TrEMBL:O06619"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44335.1"
/translation="MVHSIELVFDSDTEAAIRRIWAGLAAAGIPSQAPASRPHVSLAV
AERIAPEVDEPLGAVARRLPLDCVIGAPVLFGRANVVFTRLVVPTSELLALHAEVHRL
CGPHLAPAPMANSLPGQWTAHVTLARRVGGHQLGRALRIAGRPSRIDGRFAGLRRWDG
NTRAEYLLG"
gene complement(1779194..1779298)
/locus_tag="Rv1572c"
CDS complement(1779194..1779298)
/codon_start=1
/transl_table=11
/locus_tag="Rv1572c"
/product="Conserved hypothetical protein"
/note="Rv1572c, (MTCY336.31B), len: 34 aa. Partial
ORF,part of REP13E12 repeat element; 3' end of Rv1587c
(MTCY336.17) after phage-like element (see citation
below). Similar to C-terminal ends of other REP13E12
repeat elements e.g. Rv1148, Rv1945, Rv3467, etc. Length
extended since first submission (+7 aa). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1572c"
/db_xref="EnsemblGenomes-Tr:CCP44336"
/db_xref="UniProtKB/TrEMBL:O06618"
/protein_id="CCP44336.1"
/translation="MECSSAVHGQPRTNTFHHHEKLLRHNDEDNHDDP"
repeat_region complement(1779266..1779277)
/locus_tag="Rv1572c"
/note="12 bp direct repeat 1, ccacggccaacc, flanking
phage-like element, second site at 1788514..1788525. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
gene 1779314..1779724
/locus_tag="Rv1573"
CDS 1779314..1779724
/codon_start=1
/transl_table=11
/locus_tag="Rv1573"
/product="Probable PhiRv1 phage protein"
/note="Rv1573, (MTCY336.31c), len: 136 aa. Probable phiRv1
phage protein (see citation below). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1573"
/db_xref="EnsemblGenomes-Tr:CCP44337"
/db_xref="UniProtKB/TrEMBL:O06617"
/protein_id="CCP44337.1"
/translation="MTTTPARFNHLVTVTDLETGDRAVCDRDQVAETIRAWFPDAPLE
VREALVRLQAALNRHEHTGELEAFLRISVEHADAAGGDECGPAILAGRSGPEQAAINR
QLGLAGDDEPDGDDTPPWSRMIGLGGGSPAEDER"
gene 1779930..1780241
/locus_tag="Rv1574"
CDS 1779930..1780241
/codon_start=1
/transl_table=11
/locus_tag="Rv1574"
/product="Probable PhiRv1 phage related protein"
/note="Rv1574, (MTCY336.30), len: 103 aa. Probable phiRV1
phage related protein (see citation below); some
similarity to N-terminus of Rv1575|MTCY441.17 Probable
phiRV1 phage protein (166 aa), E(): 1.5e-06; and
Rv2647|MTCY336.29c Probable phiRV2 phage protein, E():
3.5e-05. Helix turn helix motif present at aa 14-35 (+3.61
SD). This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1574"
/db_xref="EnsemblGenomes-Tr:CCP44338"
/db_xref="UniProtKB/TrEMBL:L0TA08"
/protein_id="CCP44338.1"
/translation="MGYKPESERHSTKTDTAIGAALGISAGTYRRLKRIDNATHSDDK
EIRRFAEKQMAPLVAGSPSWNARKPRSANARVVASVHRSPMPALVPWNQSRLSATLTR
R"
repeat_region complement(1779959..1780047)
/note="89 bp direct repeat 2, first copy at
1780485..1780573, GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCC
GGCGGAGATGCCGAGGGC TG CGCCGATAGCAGTGTCTGTTTTCGTCGAA. This
region is a possible MT-complex-specific genomic island
(See Becq et al.,2007)."
gene 1780199..1780699
/locus_tag="Rv1575"
CDS 1780199..1780699
/codon_start=1
/transl_table=11
/locus_tag="Rv1575"
/product="Probable PhiRv1 phage protein"
/note="Rv1575, (MTCY336.29c), len: 166 aa. Probable phiRV1
phage protein (see citation below), showing similarity in
N-terminal part to Rv1574|MTCY336.30c Probable phiRV1
phage protein (103 aa), FASTA score: opt: 375, E():
3.8e-16,(60.2% identity in 103 aa overlap); and Rv2647
Probable phiRV2 phage protein. Start changed since first
submission (+49 aa). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv1575"
/db_xref="EnsemblGenomes-Tr:CCP44339"
/db_xref="UniProtKB/TrEMBL:L0T9U5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44339.1"
/translation="MEPKPSQRHTDKEVGAALGISAGTYKRLKRIDNATRSDDKEIRL
FAEKQMAPLAAGSPSWNGRKPSSGNRKAATMAARLDILAWGPWAPSQNRSVVRRKQTL
LSAQPSASPPAPTGGSNESTTQPAASWRVGGPAPLSRGRPRLALSYLRGSLHLQNSKR
VAHQHI"
repeat_region complement(1780485..1780573)
/note="89 bp direct repeat 1, second copy at
1779959..1780047, GGGTTGCGTTGTCGATTCGTTTGAGCCGCCGGTAGGTGCC
GGCGGAGATGCCGAGGGC TG CGCCGATAGCAGTGTCTGTTTTCGTCGAA. Many
repeats, both direct and inverted, in this region. This
region is a possible MT-complex-specific genomic island
(See Becq et al.,2007)."
gene complement(1780643..1782064)
/locus_tag="Rv1576c"
CDS complement(1780643..1782064)
/codon_start=1
/transl_table=11
/locus_tag="Rv1576c"
/product="Probable PhiRv1 phage protein"
/note="Rv1576c, (MTCY336.28), len: 473 aa. Probable phiRV1
phage protein (capsid subunit) (see citation below).
Highly similar to hypothetical Mycobacterium tuberculosis
protein Rv2650c|MTCY441.19 phiRV2 phage related protein,
FASTA scores: opt: 2782, E(): 0, (89.1% identity in 468 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1576c"
/db_xref="EnsemblGenomes-Tr:CCP44340"
/db_xref="GOA:O06614"
/db_xref="InterPro:IPR024455"
/db_xref="UniProtKB/TrEMBL:O06614"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44340.1"
/translation="MTEFDDIKNLSLPETRDAAKQLLDSVAGDLTGEAAQRFQALTRH
AEELRAEQRRRGREAEEALRRYRAGELRVVPGAPTGGDDGDAPPGNSLRDTAFRTLDS
CVRDGLMSSRAAETAETLCRTGPPQSTSWAQRWLAATGSRDYLGAFVKRVSNPVAGHT
VWTDREAAAWREAAAVAAEQRAMGLVDTQGGFLIPAALDPAILLSGDGSTNPIRQVAR
VVQTTSEIWRGVTSEGAEARWYSEAQEVSDDSPALAQPAVPNYRGSCWIPFSIELEGD
AASFVGEIGKILADSVEQLQAAAFVNGSGNGEPTGFVSALTGTSDQVVVGAGSEAIVA
ADVYALQSALPPRFQASAAFAANLSTINTLRQAETSNGALKFPSLHDSPPMLAGKSVL
EVSHMDTVDSAVTATNHPLVLGDWKQFLIGDRVGSMVELVPHLFGPNRRPTGQRGFFA
WFRVGSDVLVRNAFRVLKVETTA"
gene complement(1782072..1782584)
/locus_tag="Rv1577c"
CDS complement(1782072..1782584)
/codon_start=1
/transl_table=11
/locus_tag="Rv1577c"
/product="Probable PhiRv1 phage protein"
/note="Rv1577c, (MTCY336.27), len: 170 aa. Probable phiRv1
phage protein (prohead protease) (see citation below).
Highly similar to hypothetical protein Rv2651c|MTCY441.20c
phiRV2 prohead protease, FASTA scores: E(): 0, (89.3%
identity in 169 aa overlap). Some similarity to
VP4_BPHK7|P49860 putative bacteriophage HK97 prohead
protease (gp4) (225 aa), FASTA results: opt: 176, E():
1.3e-05, (27.3% identity in 165 aa overlap). This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1577c"
/db_xref="EnsemblGenomes-Tr:CCP44341"
/db_xref="InterPro:IPR006433"
/db_xref="UniProtKB/TrEMBL:O06613"
/protein_id="CCP44341.1"
/translation="MAELRSGEGRTVHGTIVPYNEATTVRDFDGEFQEMFAPGAFRRS
IAERGHKLKLLVSHDARTRYPVGRAVELREEPHGLFGAFEIADTPDGDEALANVKAGV
VDSFSVGFRPIRDRREGDVLVRVEAALLEVSLTGVPAYSGAQIAGVRAESLTVVSRST
AEAWLSLLDW"
gene complement(1782758..1783228)
/locus_tag="Rv1578c"
CDS complement(1782758..1783228)
/codon_start=1
/transl_table=11
/locus_tag="Rv1578c"
/product="Probable PhiRv1 phage protein"
/note="Rv1578c, (MTCY336.26), len: 156 aa. Probable phiRv1
phage protein (terminase) (see citation below), highly
similar to Rv2652c|MTCY441.21c phiRV2 phage protein from
Mycobacterium tuberculosis, FASTA scores: E():
4.8e-22,(48.1% identity in 156 aa overlap). Also similar
to X65555|ARP3COS_1 hypothetical protein (cos site)
-actinophage RP3 (210 aa), FASTA scores: opt: 373, E():
6.5e-17, (50.0% identity in 114 aa overlap). Contains MIP
family signature (PS00221). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1578c"
/db_xref="EnsemblGenomes-Tr:CCP44342"
/db_xref="InterPro:IPR006448"
/db_xref="InterPro:IPR022357"
/db_xref="UniProtKB/TrEMBL:O06612"
/inference="protein motif:PROSITE:PS00221"
/protein_id="CCP44342.1"
/translation="MPRPPKPARLKLVEGRSPGRDSGGRKVPESPKFIRQAPDAPDWL
DAEALAEWRRVAPTLERLDLLKPEDRALLSAYCETWSVYVAAVQRVRAEGLTITSPKS
GVVHRNPAVTVAETARMHLLRLASEFGLTPAAEQRLAVAPGDDGDGLNPFAPDR"
gene complement(1783309..1783623)
/locus_tag="Rv1579c"
CDS complement(1783309..1783623)
/codon_start=1
/transl_table=11
/locus_tag="Rv1579c"
/product="Probable PhiRv1 phage protein"
/note="Rv1579c, (MTCY336.25), len: 104 aa. Probable phiRv1
phage protein (see citation below). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1579c"
/db_xref="EnsemblGenomes-Tr:CCP44343"
/db_xref="UniProtKB/TrEMBL:O06611"
/protein_id="CCP44343.1"
/translation="MTPINRPLTNDERQLMHELAVQVVCSQTGCSPDAAVEALESFAK
DGTLILRGDTENAYLEAGGNVLVHADRDWLAFHASYPGNDPLRDARPIEQDDDQGAGS
PS"
gene complement(1783620..1783892)
/locus_tag="Rv1580c"
CDS complement(1783620..1783892)
/codon_start=1
/transl_table=11
/locus_tag="Rv1580c"
/product="Probable PhiRv1 phage protein"
/note="Rv1580c, (MTCY336.24), len: 90 aa. Probable phiRv1
phage protein (see citation below). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1580c"
/db_xref="EnsemblGenomes-Tr:CCP44344"
/db_xref="UniProtKB/TrEMBL:O06610"
/protein_id="CCP44344.1"
/translation="MAETPDHAELRRRIADMAFNADVGMATCKRCGDAVPYIILPNLQ
TGEPVMGVADNKWKRANCPVDVGKPCPFLIAEGVADSTDDTIEVDQ"
gene complement(1783906..1784301)
/locus_tag="Rv1581c"
CDS complement(1783906..1784301)
/codon_start=1
/transl_table=11
/locus_tag="Rv1581c"
/product="Probable PhiRv1 phage protein"
/note="Rv1581c, (MTCY336.23), len: 131 aa. Probable phiRv1
phage protein (see citation below). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1581c"
/db_xref="EnsemblGenomes-Tr:CCP44345"
/db_xref="InterPro:IPR036869"
/db_xref="UniProtKB/TrEMBL:O06609"
/protein_id="CCP44345.1"
/translation="MTAVAITPASGGRHSVRFAYDSAIVSLIKSTIPAYARSWSAHTR
CWFIDADWTPLLAAELRYHGHTVTGPADPAQQQCTDWAKALFRAVGPQRTPAVYRALS
KVLHPDAPTGCPILQQQLNAARTALTNPA"
gene complement(1784497..1785912)
/locus_tag="Rv1582c"
CDS complement(1784497..1785912)
/codon_start=1
/transl_table=11
/locus_tag="Rv1582c"
/product="Probable PhiRv1 phage protein"
/note="Rv1582c, (MTCY336.22), len: 471 aa. Probable phiRv1
phage protein (see citation below). N-terminus is similar
to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519
aa), FASTA scores: opt: 331, E(): 6.5e-15, (28.5% identity
in 235 aa overlap); and C-terminus to whole of Q38031
ORF10 of Bacteriophage phi-C31 (202 aa), FASTA scores:
opt: 353,E(): 1e-16, (31.1% identity in 190 aa overlap).
Also similar to part of AB016282|AB016282_42 Bacteriophage
phi-105 (806 aa), FASTA scores: opt: 790, E(): 0, (32.7%
identity in 459 aa overlap). Similarity to other phage
proteins described as putative DNA-polymerase or
DNA-primase. Also slightly similar to MTCY441.24c, FASTA
scores: E(): 0.0055, (36.0% identity in 75 aa overlap).
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1582c"
/db_xref="EnsemblGenomes-Tr:CCP44346"
/db_xref="GOA:O06608"
/db_xref="InterPro:IPR006500"
/db_xref="InterPro:IPR014015"
/db_xref="InterPro:IPR014818"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O06608"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44346.1"
/translation="MADIPYGTDYPDAPWIDRDGHVLIDDGGKPTQVHRGQARIAYRL
AERYQDKLLHVAGIGWHSWDGRRWAADDRGEAKRAVLAELRQALSDSLNDKELRADVR
KCESASGVAGVLDLAAALVPFAATVADLDSDPHLLNVANGTLDLHTLKLRPHAPADRI
TKICRGAYQSDTESPLWQAFLTRVLPDEGVRGFVQRLAGVGLLGTVREHVLAILIGVG
ANGKSVFDKAIRYALGDYACTAEPDLFMHRENAHPTGEMDLRGVRWVAVSESEKDRRL
AESTIKRLTGGDTIRARKMRQDFVEFTPSHTPLLITNHLPRVPGDDTAIWRRIRVVPF
EVVIPADEQDRELDARLQLEADSILSWAVAGWSDYQRIGLSQPDAVLAATSNYREDSD
TIKRFIDDECVTSSPVLKATTTHLFEAWQRWRVQEGVPEISRKAFGQSLDTHGYPVTD
KARDGRWRAGIAVRGADDFDD"
gene complement(1785912..1786310)
/locus_tag="Rv1583c"
CDS complement(1785912..1786310)
/codon_start=1
/transl_table=11
/locus_tag="Rv1583c"
/product="Probable PhiRv1 phage protein"
/note="Rv1583c, (MTCY336.21), len: 132 aa. Probable phiRv1
phage protein (see citation below), highly similar to
Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA
score: E(): 1.3e-33, (81.7% identity in 131 aa overlap).
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1583c"
/db_xref="EnsemblGenomes-Tr:CCP44347"
/db_xref="InterPro:IPR024384"
/db_xref="UniProtKB/Swiss-Prot:P9WLU1"
/protein_id="CCP44347.1"
/translation="MTAGAGGSPPTRRCPATEDRAPATVATPSSADPTASRAVSWWSV
HEHVAPVLDAAGSWPMAGTPAWRQLDDADPRKWAAICDAARHWALRVETCQEAMAQAS
RDVSAAADWPGIAREIVRRRGVYIPRAGVA"
gene complement(1786307..1786528)
/locus_tag="Rv1584c"
CDS complement(1786307..1786528)
/codon_start=1
/transl_table=11
/locus_tag="Rv1584c"
/product="Possible PhiRv1 phage protein"
/note="Rv1584c, (MTCY336.20), len: 73 aa. Possible phiRv1
phage protein (putative excisionase) (see citation below).
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1584c"
/db_xref="EnsemblGenomes-Tr:CCP44348"
/db_xref="UniProtKB/TrEMBL:O06606"
/protein_id="CCP44348.1"
/translation="MSTIYHHRGRVAALSRSRASDDPEFIAAKTDLVAANIADYLIRT
LAAAPPLTDEQRTRLAELLRPVRRSGGAR"
gene complement(1786584..1787099)
/locus_tag="Rv1585c"
CDS complement(1786584..1787099)
/codon_start=1
/transl_table=11
/locus_tag="Rv1585c"
/product="Possible phage PhiRv1 protein"
/note="Rv1585c, (MTCY336.19), len: 171 aa. Possible phage
phiRv1 protein (see Hatfull 2000). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1585c"
/db_xref="EnsemblGenomes-Tr:CCP44349"
/db_xref="UniProtKB/TrEMBL:O06605"
/protein_id="CCP44349.1"
/translation="MSRHHNIVIVCDHGRKGDGRIEHERCDLVAPIIWVDETQGWLPQ
APAVATLLDDDNQPRAVIGLPPNESRLRPEMRRDGWVRLHWEFACLRYGAAGVRTCEQ
RPVRVRNGDLQTLCENVPRLLTGLAGNPDYAPGFAVQSDAVVVAMWLWRTLCESDTPN
KLRATPTRGSC"
gene complement(1787096..1788505)
/locus_tag="Rv1586c"
CDS complement(1787096..1788505)
/codon_start=1
/transl_table=11
/locus_tag="Rv1586c"
/product="Probable PhiRv1 integrase"
/note="Rv1586c, (MTCY336.18), len: 469 aa. Probable phiRv1
integrase, possibly member of the serine family of
recombinases (see citation below), similar to several
bacteriophage integrases e.g. Q37839 ORF469 protein from
Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E():
1.6e-29, (31.1% identity in 482 aa overlap); and
Bacteriophage TP901-1. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1586c"
/db_xref="EnsemblGenomes-Tr:CCP44350"
/db_xref="GOA:O06604"
/db_xref="InterPro:IPR006119"
/db_xref="InterPro:IPR011109"
/db_xref="InterPro:IPR036162"
/db_xref="UniProtKB/TrEMBL:O06604"
/protein_id="CCP44350.1"
/translation="MRYTTPVRAAVYLRISEDRSGEQLGVARQREDCLKLCGQRKWVP
VEYLDNDVSASTGKRRPAYEQMLADITAGKIAAVVAWDLDRLHRRPIELEAFMSLADE
KRLALATVAGDVDLATPQGRLVARLKGSVAAHETEHKKARQRRAARQKAERGHPNWSK
AFGYLPGPNGPEPDPRTAPLVKQAYADILAGASLGDVCRQWNDAGAFTITGRPWTTTT
LSKFLRKPRNAGLRAYKGARYGPVDRDAIVGKAQWSPLVDEATFWAAQAVLDAPGRAP
GRKSVRRHLLTGLAGCGKCGNHLAGSYRTDGQVVYVCKACHGVAILADNIEPILYHIV
AERLAMPDAVDLLRREIHDAAEAETIRLELETLYGELDRLAVERAEGLLTARQVKIST
DIVNAKITKLQARQQDQERLRVFDGIPLGTPQVAGMIAELSPDRFRAVLDVLAEVVVQ
PVGKSGRIFNPERVQVNWR"
gene complement(1788162..1789163)
/locus_tag="Rv1587c"
CDS complement(1788162..1789163)
/codon_start=1
/transl_table=11
/locus_tag="Rv1587c"
/product="Partial REP13E12 repeat protein"
/note="Rv1587c, (MTCY336.17), len: 333 aa. Partial
REP13E12 repeat protein (see citation below), nearly
identical (but has been interrupted by phiRv1 prophage) to
Q50655|MTCY251.13c|Rv0094c hypothetical 34.6 kDa protein
from M. tuberculosis (317 aa), FASTA results: opt:
1511,E(): 1.1e-84, (97.75% identity in 224 aa overlap).
Codon usage suggests that translation may involve
frameshifting of Rv1588c mRNA in poly_C stretch into
reading frame of Rv1587c. 3' end found in Rv1572c. Length
extended since first submission (+115 aa). This region is
a possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1587c"
/db_xref="EnsemblGenomes-Tr:CCP44351"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:O06603"
/protein_id="CCP44351.1"
/translation="MLAKLAAPGATNPDDHTPVIDTTPDAAAIDRDTRSQAQRNHDGL
LAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGKGFTGGGTLLPMADVIRMTSH
AHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIMLFANDRGCTKPGCDAPAYHS
QAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHNNTHGHTEWLPPPHLDHGQPW
TCEIHYTCACCCLPPNLRRPLRRTARRGPPTRGLPKAVRAAKMGARRVPRQRRQRINR
QAPPRLRADVGRHHRRQDRRRGGLGPGPAPSPSHRAGSLHVISRREAAGPGHRRRRR"
repeat_region complement(1788514..1789811)
/note="REP-5, len: 1298 nt. REP336, member of REP13E12
family. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
repeat_region complement(1788514..1788525)
/locus_tag="Rv1587c"
/note="12 bp direct repeat 2, ccacggccaacc, flanking
phage-like element, first site at 1779266..1779277. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
gene complement(1789168..1789836)
/locus_tag="Rv1588c"
CDS complement(1789168..1789836)
/codon_start=1
/transl_table=11
/locus_tag="Rv1588c"
/product="Partial REP13E12 repeat protein"
/note="Rv1588c, (MTCY336.16), len: 222 aa. Partial
REP13E12 repeat protein (see citation below), nearly
identical to ORF's in other Rep13E12 repeats, including
Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypothetical 15.4 kd
protein cy251.14 from Mycobacterium tuberculosis (136
aa),FASTA results: opt: 613, E(): 9.9e-29, (86.5% identity
in 111 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1588c"
/db_xref="EnsemblGenomes-Tr:CCP44352"
/db_xref="GOA:P9WLT9"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P9WLT9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44352.1"
/translation="MLANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLE
CLVRRLPAVGHALINQLDAQASEEELGGTLCCALANRLRITKPDAARRIADAADLGPR
RALTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFRPPARRGGCVHPPGRRSRPGRQ
SRSISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPS
AGHL"
gene 1790284..1791333
/gene="bioB"
/locus_tag="Rv1589"
CDS 1790284..1791333
/codon_start=1
/transl_table=11
/gene="bioB"
/locus_tag="Rv1589"
/product="Probable biotin synthetase BioB"
/note="Rv1589, (MTCY336.15c), len: 349 aa. Probable
bioB,biotin synthetase O06601. Highly similar to
BIOB_MYCLE|P46715 BioB from Mycobacterium leprae (345
aa),FASTA results: opt: 1982, E(): 0, (86.5% identity in
349 aa overlap). Identical to AF041819|AF041819_9 bioB
from Mycobacterium bovis BCG (349 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1589"
/db_xref="EnsemblGenomes-Tr:CCP44353"
/db_xref="GOA:P9WPQ7"
/db_xref="InterPro:IPR002684"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR010722"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR024177"
/db_xref="UniProtKB/Swiss-Prot:P9WPQ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44353.1"
/translation="MTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLA
VLQLPDDRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFASPV
RSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAAGIEAIRNEVEINIA
CSLGMLTAEQVDQLAARGVHRYNHNLETARSFFANVVTTHTWEERWQTLSMVRDAGME
VCCGGILGMGETLQQRAEFAAELAELGPDEVPLNFLNPRPGTPFADLEVMPVGDALKA
VAAFRLALPRTMLRFAGGREITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLEL
LDELQMPLKALNASL"
gene 1791334..1791573
/locus_tag="Rv1590"
CDS 1791334..1791573
/codon_start=1
/transl_table=11
/locus_tag="Rv1590"
/product="Conserved hypothetical protein"
/note="Rv1590, (MTCY336.14c), len: 79 aa. Conserved
hypothetical protein, similar to
Q49616|LEPB1170_C1_162|YF90_MYCLE from Mycobacterium
leprae (80 aa), FASTA scores: opt: 368, E():
1.7e-21,Smith-Waterman score: 368, (67.1% identity in 73
aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1590"
/db_xref="EnsemblGenomes-Tr:CCP44354"
/db_xref="GOA:P9WLT7"
/db_xref="UniProtKB/Swiss-Prot:P9WLT7"
/protein_id="CCP44354.1"
/translation="MVEIVAGKQRAPVAAGVYNVYTGELADTATPTAARMGLEPPRFC
AQCGRRMVVQVRPDGWWARCSRHGQVDSADLATQR"
gene 1791570..1792235
/locus_tag="Rv1591"
CDS 1791570..1792235
/codon_start=1
/transl_table=11
/locus_tag="Rv1591"
/product="Probable transmembrane protein"
/note="Rv1591, (MTCY336.13c), len: 221 aa. Probable
transmembrane protein, similar to
Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical
Mycobacterium leprae protein (198 aa), FASTA results: opt:
802, E(): 0, (63.8% identity in 188 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1591"
/db_xref="EnsemblGenomes-Tr:CCP44355"
/db_xref="GOA:P9WLT5"
/db_xref="InterPro:IPR021213"
/db_xref="UniProtKB/Swiss-Prot:P9WLT5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44355.1"
/translation="MTEPPGFGGPSEPSGAPRTSRTRAVLFVMLGLSATGVLVGGLWA
WIAPPIHAVVAITRAGERVHEYLGSESQNFFIAPFMLLGLLSVLAVVASALMWQWREH
RGPQMVAGLSIGLTTAAAIAAGVGALVVRLRYGALDFDTVPLSRGDHALTYVTQAPPV
FFARRPLQIALTLMWPAGIASLVYALLAAGTARDDLGGYPAVDPSSNARTEALETPQA
PVS"
gene complement(1792400..1793740)
/locus_tag="Rv1592c"
CDS complement(1792400..1793740)
/codon_start=1
/transl_table=11
/locus_tag="Rv1592c"
/product="Conserved hypothetical protein"
/note="Rv1592c, (MTCY336.12), len: 446 aa. Conserved
hypothetical protein, some similarity to
Q49629|B1170_F1_46 from Mycobacterium leprae (132 aa),
FASTA results: opt: 332, E(): 4.5e-14, (56.3% identity in
87 aa overlap). Nearly identical to truncated
Mycobacterium bovis BCG protein (148 aa)
AF041819|AF041819_11."
/db_xref="EnsemblGenomes-Gn:Rv1592c"
/db_xref="EnsemblGenomes-Tr:CCP44356"
/db_xref="GOA:P9WK89"
/db_xref="InterPro:IPR005152"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WK89"
/protein_id="CCP44356.1"
/translation="MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDDPFYFPPAG
YQHAVPGTVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIVPAELAP
GQTCPLLSYQCAIDAMSSRCFPSYALRRRAKALGSLTQMELLMISAALAEGWAVSVPD
HEGPKGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAWAAEAC
GEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAALQHSYPGLARVIKEH
ANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEPLEDILSTPEISHVFGDTKLGSA
VPTPPVLIVQAVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTL
RWLTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL"
gene complement(1793997..1794707)
/locus_tag="Rv1593c"
CDS complement(1793997..1794707)
/codon_start=1
/transl_table=11
/locus_tag="Rv1593c"
/product="Conserved protein"
/note="Rv1593c, (MTCY336.11), len: 236 aa. Conserved
protein, highly similar to Q49628|B1170_F1_44 from
Mycobacterium leprae (286 aa), FASTA scores: opt: 1304, E
(): 0, (85.4% identity in 233 aa overlap); similar to
several putative DNA hydrolases e.g. Q9S233|SCI51.07C from
Streptomyces coelicolor (239 aa), FASTA scores: opt:
415,E(): 4.6e-20, (34.8% identity in 221 aa overlap); also
similar to P74291|SLR1690 hypothetical protein from
synechocystis (261 aa), FASTA scores: opt: 228, E():
1.4e-17, (31.5% identity in 213 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1593c"
/db_xref="EnsemblGenomes-Tr:CCP44357"
/db_xref="GOA:O06597"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O06597"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44357.1"
/translation="MAHGSTAHEVLAVVFQVRGVGMSRGAAKPQLNVLLWQRAKEPQR
GAWSLPGGRLRNDEDMTSSVRRQLAEKVDLRELAHLEQLAVFSDPHRLPGIRMIASTY
LGVVPSPATPELPADTRWHPVSSLPPMAFDHGPMVTHARTRLIAKMSYTNIGFALAPK
EFALSTLRDIYGAALGYQVDATNLQRVLARRRVITQTGTIAQSGRSGGRPAALYRFTD
SQLRVTDEFAALRPPGQL"
gene 1794756..1795805
/gene="nadA"
/locus_tag="Rv1594"
CDS 1794756..1795805
/codon_start=1
/transl_table=11
/gene="nadA"
/locus_tag="Rv1594"
/product="Probable quinolinate synthetase NadA"
/note="Rv1594, (MTCY336.10c), len: 349 aa. Probable
nadA,quinolinate synthetase. Similar to many e.g. Q49622
NADA from Mycobacterium leprae (368 aa), FASTA results:
opt: 1994, E(): 0, (84.4% identity in 352 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1594"
/db_xref="EnsemblGenomes-Tr:CCP44358"
/db_xref="GOA:P9WJK1"
/db_xref="InterPro:IPR003473"
/db_xref="InterPro:IPR023066"
/db_xref="InterPro:IPR036094"
/db_xref="UniProtKB/Swiss-Prot:P9WJK1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44358.1"
/translation="MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHL
RGATVLAHNYQLPAIQDVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILSPH
KTVLIPDQRAGCSLADSITPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNA
VDVVASIDPDREVLFCPDQFLGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARA
HPDAELFVHPECGCATSALYLAGEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEV
GMLHQLRRAAPEVDFRAVNDRASCKYMKMITPAALLRCLVEGADEVHVDPGIAASGRR
SVQRMIEIGHPGGGE"
gene 1795805..1797388
/gene="nadB"
/locus_tag="Rv1595"
CDS 1795805..1797388
/codon_start=1
/transl_table=11
/gene="nadB"
/locus_tag="Rv1595"
/product="Probable L-aspartate oxidase NadB"
/note="Rv1595, (MTCY336.09c), len: 527 aa. Probable
nadB,L-aspartate oxidase. Similar to many e.g. Q49617
L-aspartate oxidase (quinolinate synthetase) from
Mycobacterium leprae (424 aa), FASTA results: opt:
2152,E(): 0, (82.0% identity in 400 aa overlap). Also
shows some similarity to Rv1552 frdA from Mycobacterium
tuberculosis (583 aa), FASTA results: E(): 1e-10, (35.3%
identity in 566 aa overlap). Heterodimer. The quinolinate
synthetase complex consists of the two enzymes quinolinate
synthetase a and B."
/db_xref="EnsemblGenomes-Gn:Rv1595"
/db_xref="EnsemblGenomes-Tr:CCP44359"
/db_xref="GOA:P9WJJ9"
/db_xref="InterPro:IPR003953"
/db_xref="InterPro:IPR005288"
/db_xref="InterPro:IPR015939"
/db_xref="InterPro:IPR027477"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR037099"
/db_xref="UniProtKB/Swiss-Prot:P9WJJ9"
/protein_id="CCP44359.1"
/translation="MAGPAWRDAADVVVIGTGVAGLAAALAADRAGRSVVVLSKAAQT
HVTATHYAQGGIAVVLPDNDDSVDAHVADTLAAGAGLCDPDAVYSIVADGYRAVTDLV
GAGARLDESVPGRWALTREGGHSRRRIVHAGGDATGAEVQRALQDAAGMLDIRTGHVA
LRVLHDGTAVTGLLVVRPDGCGIISAPSVILATGGLGHLYSATTNPAGSTGDGIALGL
WAGVAVSDLEFIQFHPTMLFAGRAGGRRPLITEAIRGEGAILVDRQGNSITAGVHPMG
DLAPRDVVAAAIDARLKATGDPCVYLDARGIEGFASRFPTVTASCRAAGIDPVRQPIP
VVPGAHYSCGGIVTDVYGQTELLGLYAAGEVARTGLHGANRLASNSLLEGLVVGGRAG
KAAAAHAAAAGRSRATSSATWPEPISYTALDRGDLQRAMSRDASMYRAAAGLHRLCDS
LSGAQVRDVACRRDFEDVALTLVAQSVTAAALARTESRGCHHRAEYPCTVPEQARSIV
VRGADDANAVCVQALVAVC"
gene 1797388..1798245
/gene="nadC"
/locus_tag="Rv1596"
CDS 1797388..1798245
/codon_start=1
/transl_table=11
/gene="nadC"
/locus_tag="Rv1596"
/product="Probable nicotinate-nucleotide pyrophosphatase
NadC"
/note="Rv1596, (MTCY336.08c), len: 285 aa. Probable
nadC,nicotinate-nucleotide pyrophosphatase O06594. Similar
to many e.g. ADC_MYCLE|P46714 from Mycobacterium leprae
(284 aa), FASTA results: opt: 1418, E(): 0,(79.2% identity
in 283 aa overlap). Belongs to the NADC/MODD family."
/db_xref="EnsemblGenomes-Gn:Rv1596"
/db_xref="EnsemblGenomes-Tr:CCP44360"
/db_xref="GOA:P9WJJ7"
/db_xref="InterPro:IPR002638"
/db_xref="InterPro:IPR004393"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR022412"
/db_xref="InterPro:IPR027277"
/db_xref="InterPro:IPR036068"
/db_xref="InterPro:IPR037128"
/db_xref="PDB:1QPN"
/db_xref="PDB:1QPO"
/db_xref="PDB:1QPQ"
/db_xref="PDB:1QPR"
/db_xref="UniProtKB/Swiss-Prot:P9WJJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44360.1"
/translation="MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTAS
LVTREAGVVAGLDVALLTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLT
AERTMLNLVGHLSGIATATAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVN
HRLGLGDAALIKDNHVAAAGSVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPEL
ILLDNFAVWQTQTAVQRRDSRAPTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSV
RVLDIGLDM"
gene 1798294..1799052
/locus_tag="Rv1597"
CDS 1798294..1799052
/codon_start=1
/transl_table=11
/locus_tag="Rv1597"
/product="Hypothetical protein"
/note="Rv1597, (MTCY336.07c), len: 252 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1597"
/db_xref="EnsemblGenomes-Tr:CCP44361"
/db_xref="GOA:O06593"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O06593"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44361.1"
/translation="MARTFEDLVAEAASASVGGWGFSWLDGRATEERPSWGYQRQLSQ
RLANATAALDLETGGGEVLAGAGNFPPTMVATEAWPPNAAMATRRLHPLGAVVVITGD
KPPLPFADAAFDLVTSRHPSTRWWTEIARVLRAGGSYFAQHVGPATLWDLREHFLGPR
EHNGADQYAQVVRTCITDAGLEIVDLQMERLRVEFFDVGAVIYFLRKVIWFLPDFTVE
GYHDRLRALHERIQAEGPFVTYSTRALIEARKPS"
gene complement(1799073..1799483)
/locus_tag="Rv1598c"
CDS complement(1799073..1799483)
/codon_start=1
/transl_table=11
/locus_tag="Rv1598c"
/product="Conserved protein"
/note="Rv1598c, (MTCY336.06), len: 136 aa. Conserved
protein, some similarity to O06389|Rv0523c|MTCY25D10.02
from Mycobacterium tuberculosis (131 aa), FASTA scores:
E(): 2.2e-09, (38.4% identity in 99 aa overlap); and
P95144|MTCY359.02|Rv1871c (129 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1598c"
/db_xref="EnsemblGenomes-Tr:CCP44362"
/db_xref="GOA:O06592"
/db_xref="InterPro:IPR004378"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/TrEMBL:O06592"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44362.1"
/translation="MSAKDHPNNAPGVPMVFPLWLERLQVKYINRALKPIARYLPGTA
TIEHRGRKSGKPYQTIVTAYRKDGVLAIALAHGKTDWVKNVLAAGEADVHFARGVVHV
INPRIVPAGSDGQGLPRMARLQLRRIGVFVGDIA"
gene 1799583..1800899
/gene="hisD"
/locus_tag="Rv1599"
CDS 1799583..1800899
/codon_start=1
/transl_table=11
/gene="hisD"
/locus_tag="Rv1599"
/product="Probable histidinol dehydrogenase HisD (HDH)"
/note="Rv1599, (MTCY336.05c), len: 438 aa. Probable
hisD,histidinol dehydrogenase (see citation below) O08396.
Similar to many e.g. HISX_MYCSM|P28736 from Mycobacterium
smegmatis (445 aa), FASTA results: opt: 2356, E():
0,(83.1% identity in 437 aa overlap). Contains histidinol
dehydrogenase signature (PS00611)."
/db_xref="EnsemblGenomes-Gn:Rv1599"
/db_xref="EnsemblGenomes-Tr:CCP44363"
/db_xref="GOA:P9WNW9"
/db_xref="InterPro:IPR001692"
/db_xref="InterPro:IPR012131"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR022695"
/db_xref="UniProtKB/Swiss-Prot:P9WNW9"
/inference="protein motif:PROSITE:PS00611"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44363.1"
/translation="MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAE
RGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQR
RTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVAS
PPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITG
PGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASV
LVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAA
EHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSV
QTFLRGIHVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER"
gene 1800896..1802038
/gene="hisC1"
/gene_synonym="hisC"
/locus_tag="Rv1600"
CDS 1800896..1802038
/codon_start=1
/transl_table=11
/gene="hisC1"
/gene_synonym="hisC"
/locus_tag="Rv1600"
/product="Probable histidinol-phosphate aminotransferase
HisC1"
/note="Rv1600, (MTCY336.04c), len: 380 aa. Probable
hisC1,histidinol-phosphate aminotransferase O06591.
Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces
coelicolor (369 aa), FASTA results: opt: 1353, E(): 0,
(59.0% identity in 356 aa overlap). Some similarity to
other Mycobacterium tuberculosis aminotransferases e.g.
Rv3772|MTCY13D12.06,FASTA results: E(): 7.4e-25, (33.7%
identity in 365 aa overlap). Contains aminotransferases
class-II pyridoxal-phosphate attachment site (PS00599).
Belongs to class-II of pyridoxal-phosphate-dependent
aminotransferases. Note that previously known as hisC."
/db_xref="EnsemblGenomes-Gn:Rv1600"
/db_xref="EnsemblGenomes-Tr:CCP44364"
/db_xref="GOA:P9WML7"
/db_xref="InterPro:IPR001917"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR005861"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="PDB:4R8D"
/db_xref="PDB:4RAE"
/db_xref="UniProtKB/Swiss-Prot:P9WML7"
/inference="protein motif:PROSITE:PS00599"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44364.1"
/translation="MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHP
PTRALVDDVVRSVREAAIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGS
NEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAA
VVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVE
EYPSKLVVTRTMSKAFAFAGGRLGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALR
HSDDTLSSVAALIAERERVTTSLNDMGFRVIPSDANFVLFGEFADAPAAWRRYLEAGI
LIRDVGIPGYLRATTGLAEENDAFLRASARIATDLVPVTRSPVGAP"
gene 1802035..1802667
/gene="hisB"
/locus_tag="Rv1601"
CDS 1802035..1802667
/codon_start=1
/transl_table=11
/gene="hisB"
/locus_tag="Rv1601"
/product="Probable imidazole glycerol-phosphate
dehydratase HisB"
/note="Rv1601, (MTCY336.03c), len: 210 aa. Probable
hisB,imidazole glycerol-phosphate dehydratase. Similar to
many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor
(197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity
in 202 aa overlap). Belongs to the
imidazoleglycerol-phosphate dehydratase family."
/db_xref="EnsemblGenomes-Gn:Rv1601"
/db_xref="EnsemblGenomes-Tr:CCP44365"
/db_xref="GOA:P9WML9"
/db_xref="InterPro:IPR000807"
/db_xref="InterPro:IPR020565"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR038494"
/db_xref="PDB:4GQU"
/db_xref="PDB:5XDS"
/db_xref="PDB:5ZQN"
/db_xref="UniProtKB/Swiss-Prot:P9WML9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44365.1"
/translation="MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPF
YDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGD
AFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAAN
ARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL"
gene 1802664..1803284
/gene="hisH"
/locus_tag="Rv1602"
CDS 1802664..1803284
/codon_start=1
/transl_table=11
/gene="hisH"
/locus_tag="Rv1602"
/product="Probable amidotransferase HisH"
/note="Rv1602, (MTCY336.02c), len: 206 aa. Probable
hisH,amidotransferase. Similar to many e.g.
HIS5_STRCO|P16249 from Streptomyces coelicolor (222 aa),
FASTA results: opt: 872, E():0, (61.0% identity in 210 aa
overlap). Contains glutamine amidotransferases class-I
active site (PS00442). Belongs to the HisH family."
/db_xref="EnsemblGenomes-Gn:Rv1602"
/db_xref="EnsemblGenomes-Tr:CCP44366"
/db_xref="GOA:P9WMM1"
/db_xref="InterPro:IPR010139"
/db_xref="InterPro:IPR017926"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:P9WMM1"
/inference="protein motif:PROSITE:PS00442"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44366.1"
/translation="MTAKSVVVLDYGSGNLRSAQRALQRVGAEVEVTADTDAAMTADG
LVVPGVGAFAACMAGLRKISGERIIAERVAAGRPVLGVCVGMQILFACGVEFGVQTPG
CGHWPGAVIRLEAPVIPHMGWNVVDSAAGSALFKGLDVDARFYFVHSYAAQRWEGSPD
ALLTWATYRAPFLAAVEDGALAATQFHPEKSGDAGAAVLSSWVDGL"
gene 1803294..1804031
/gene="hisA"
/locus_tag="Rv1603"
CDS 1803294..1804031
/codon_start=1
/transl_table=11
/gene="hisA"
/locus_tag="Rv1603"
/product="Probable phosphoribosylformimino-5-
aminoimidazole carboxamide ribotide isomerase HisA"
/note="Rv1603, (MTV046.01-MTCY336.01c), len: 245 aa.
Probable hisA, phosphoribosylformimino-5-aminoimidazole
carboxamide ribotide isomerase, similar to many e.g.
HIS4_STRCO|P16250 phosphoribosylformimino-5-aminoimidaz
from Streptomyces coelicolor (240 aa), FASTA scores: opt:
1081, E(): 0, (69.0% identity in 239 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1603"
/db_xref="EnsemblGenomes-Tr:CCP44367"
/db_xref="GOA:P9WMM5"
/db_xref="InterPro:IPR006062"
/db_xref="InterPro:IPR010188"
/db_xref="InterPro:IPR011060"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR023016"
/db_xref="PDB:2Y85"
/db_xref="PDB:2Y88"
/db_xref="PDB:2Y89"
/db_xref="PDB:3ZS4"
/db_xref="UniProtKB/Swiss-Prot:P9WMM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44367.1"
/translation="MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRD
GAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVN
VGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLD
SEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHR
GVEGAIVGKALYARRFTLPQALAAVRD"
gene 1804039..1804851
/gene="impA"
/locus_tag="Rv1604"
CDS 1804039..1804851
/codon_start=1
/transl_table=11
/gene="impA"
/locus_tag="Rv1604"
/product="Probable inositol-monophosphatase ImpA (imp)"
/note="Rv1604, (MTV046.02), len: 270 aa. Probable
impA,inositol monophosphatase, similar to many e.g.
AF0059|AF005905_2 inositol monophosphate phosphatase from
Mycobacterium smegmatis (276 aa), FASTA scores: opt:
1241,E(): 0, (70.5% identity in 261 aa overlap). Also
similar to Mycobacterium tuberculosis proteins Rv3137 and
Rv2701c."
/db_xref="EnsemblGenomes-Gn:Rv1604"
/db_xref="EnsemblGenomes-Tr:CCP44368"
/db_xref="GOA:O53907"
/db_xref="InterPro:IPR000760"
/db_xref="InterPro:IPR020550"
/db_xref="UniProtKB/Swiss-Prot:O53907"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44368.1"
/translation="MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFAT
EVDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINYAAGSPLAAI
LLGLLHDGVPVAGLTWMPFTDPRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFS
ADSRGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHA
AGVALVRAAGGVVTDLAGQPWTPASRSALAGPPRVHAQILEILGSIGEPEDY"
gene 1804853..1805656
/gene="hisF"
/locus_tag="Rv1605"
CDS 1804853..1805656
/codon_start=1
/transl_table=11
/gene="hisF"
/locus_tag="Rv1605"
/product="Probable cyclase HisF"
/note="Rv1605, (MTV046.03), len: 267 aa. Probable
hisF,cyclase involved in histidine biosynthetic pathway,
similar to many e.g. AF0304|AF030405_1 Corynebacterium
glutamicum cyclase (257 aa), FASTA scores: opt: 1201, E():
0, (71.9% identity in 256 aa overlap). Belongs to the
HisA/HisF family."
/db_xref="EnsemblGenomes-Gn:Rv1605"
/db_xref="EnsemblGenomes-Tr:CCP44369"
/db_xref="GOA:P9WMM3"
/db_xref="InterPro:IPR004651"
/db_xref="InterPro:IPR006062"
/db_xref="InterPro:IPR011060"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/Swiss-Prot:P9WMM3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44369.1"
/translation="MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPV
ELAAVYDAEGADELTFLDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTVADVDS
LLRAGADKVAVNTAAIACPDLLADMARQFGSQCIVLSVDARTVPVGSAPTPSGWEVTT
HGGRRGTGMDAVQWAARGADLGVGEILLNSMDADGTKAGFDLALLRAVRAAVTVPVIA
SGGAGAVEHFAPAVAAGADAVLAASVFHFRELTIGQVKAALAAEGITVR"
gene 1805653..1806000
/gene="hisI"
/locus_tag="Rv1606"
CDS 1805653..1806000
/codon_start=1
/transl_table=11
/gene="hisI"
/locus_tag="Rv1606"
/product="Probable phosphoribosyl-AMP 1,6 cyclohydrolase
HisI"
/note="Rv1606, (MTV046.04), len: 115 aa. Probable
hisI,phosphoribosyl-AMP 1,6 cyclohydrolase, similar to
several e.g. X82010|RSHISI_2 HISI from Rhodobacter
sphaeroides (119 aa), FASTA scores: opt: 378, E():
2.8e-21, (52.3% identity in 109 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1606"
/db_xref="EnsemblGenomes-Tr:CCP44370"
/db_xref="GOA:P9WMM7"
/db_xref="InterPro:IPR002496"
/db_xref="InterPro:IPR026660"
/db_xref="InterPro:IPR038019"
/db_xref="UniProtKB/Swiss-Prot:P9WMM7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44370.1"
/translation="MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALAR
TLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDH
SCFDAAVLLEPDD"
gene 1806181..1807263
/gene="chaA"
/locus_tag="Rv1607"
CDS 1806181..1807263
/codon_start=1
/transl_table=11
/gene="chaA"
/locus_tag="Rv1607"
/product="Probable ionic transporter integral membrane
protein ChaA"
/note="Rv1607, (MTV046.05), len: 360 aa. Probable
chaA,ionic transporter integral membrane protein, putative
calcium/proton antiporter, similar to many e.g.
P31801|CHAA_ECOLI calcium/proton antiporter from
Escherichia coli (366 aa), FASTA scores: opt: 736, E():
0,(35.9% identity in 351 aa overlap). Equivalent to
Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity
in 364 aa overlap). Seems to belong to the CaCA family."
/db_xref="EnsemblGenomes-Gn:Rv1607"
/db_xref="EnsemblGenomes-Tr:CCP44371"
/db_xref="GOA:O53910"
/db_xref="InterPro:IPR004837"
/db_xref="UniProtKB/TrEMBL:O53910"
/protein_id="CCP44371.1"
/translation="MLKRVPWTVVLPSLAFVALVLTWGKQIGPVVGLLAAVLLAGAVL
AAVNHAEVVAARVGEPFGSLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVM
ITTNGIAGLSLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPELS
PGQLIFAGAASLGLYVLFLFTQTVRHRDFFLPVAQKGAVEDDSHADPPSTRAALLSLG
LLLVALVAVVGLAKVESPVIEEVVSAAGFPQSFVGVVIATLVLLPETLAAARAARQGR
LQTSLNLAYGSAMASIGLTIPTIALASLWLSGPLQLGLGAIQLVLLVLTVVVSVLTVV
PGRATRLQGEVHLVLLAAYLFLAVVP"
gene complement(1807298..1807762)
/gene="bcpB"
/locus_tag="Rv1608c"
CDS complement(1807298..1807762)
/codon_start=1
/transl_table=11
/gene="bcpB"
/locus_tag="Rv1608c"
/product="Probable peroxidoxin BcpB"
/note="Rv1608c, (MTV046.06), len: 154 aa. Probable
bcpB,peroxidoxin or bacterioferritin comigratory
protein,similar to many, e.g. AE0003|ECAE000335_4
bacterioferritin comigratory protein from Escherichia coli
K-12 MG1655 (156 aa), FASTA scores: opt: 329, E():
1.2e-16, (38.2% identity in 152 aa overlap);
Z97179|MLCL383_22 Mycobacterium leprae cosmid L383 (161
aa) (40.2% identity in 132 aa overlap). Also similar to
Rv2428 AhpC, alkyl hydroperoxide reductase from
Mycobacterium tuberculosis; and other Mycobacterium
tuberculosis putative peroxidoxins Rv2521,
Rv2238c,Rv1932."
/db_xref="EnsemblGenomes-Gn:Rv1608c"
/db_xref="EnsemblGenomes-Tr:CCP44372"
/db_xref="GOA:P9WID9"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR024706"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:5EPF"
/db_xref="UniProtKB/Swiss-Prot:P9WID9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44372.1"
/translation="MKTGDTVADFELPDQTGTPRRLSVLLSDGPVVLFFYPAAMTPGC
TKEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVRRFDYPLLSDAQGTVAAQFG
VKRGLLGKLMPVKRTTFVIDTDRKVLDVISSEFSMDAHADKALATLRAIRSG"
gene 1807903..1809453
/gene="trpE"
/locus_tag="Rv1609"
CDS 1807903..1809453
/codon_start=1
/transl_table=11
/gene="trpE"
/locus_tag="Rv1609"
/product="Anthranilate synthase component I TrpE
(glutamine amidotransferase)"
/note="Rv1609, (MTCY01B2.01, MTV046.07), len: 516 aa.
trpE,anthranilate synthase component I. FASTA best:
TRPE_CLOTM|P14953 anthranilate synthase component I from
Clostridium thermocellum (494 aa), E(): 0, (42.6% identity
in 498 aa overlap). Some similarity to
Rv2386c|MTCY253.35,E(): 6.3e-17; and Rv3215|MTCY07D11.11c,
E(): 5.7e-15. Belongs to the anthranilate synthase
component I family."
/db_xref="EnsemblGenomes-Gn:Rv1609"
/db_xref="EnsemblGenomes-Tr:CCP44373"
/db_xref="GOA:P9WFX3"
/db_xref="InterPro:IPR005256"
/db_xref="InterPro:IPR005801"
/db_xref="InterPro:IPR006805"
/db_xref="InterPro:IPR015890"
/db_xref="InterPro:IPR019999"
/db_xref="UniProtKB/Swiss-Prot:P9WFX3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44373.1"
/translation="MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKL
AANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLR
ALQVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLL
LATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVA
TFSRPEPRHRAQRTVEEYGAIVEYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRIL
RVTNPSPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDE
DVLLEKELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVST
VTGKLGEGRTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAG
NADFAIAIRTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARAVLNAIAAAETLAA
PGANRSGC"
gene 1809443..1810150
/locus_tag="Rv1610"
CDS 1809443..1810150
/codon_start=1
/transl_table=11
/locus_tag="Rv1610"
/product="Possible conserved membrane protein"
/note="Rv1610, (MTCY01B2.02), len: 235 aa. Possible
conserved membrane protein. Equivalent to
AL049913|MLCB1610_23 hypothetical protein from
Mycobacterium leprae (264 aa), FASTA score: (65.8%
identity in 231 aa overlap). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004)."
/db_xref="EnsemblGenomes-Gn:Rv1610"
/db_xref="EnsemblGenomes-Tr:CCP44374"
/db_xref="GOA:O06128"
/db_xref="InterPro:IPR011746"
/db_xref="InterPro:IPR019051"
/db_xref="UniProtKB/TrEMBL:O06128"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44374.1"
/translation="MAANAGSVRPNRRARPMIGIAQLLLVVAAGALWMAARLPWVVIG
SFDELGPPKEVTLTGASWSTALLPLALLMLAAAVAALAVRGWPLRALAVLLAAASFAV
GYLGISLWVVPDVAARGADLAHVPVVTLVGSARHYWGAVAAVLAAVCALLAAVFLMSS
AAIRGSAGEDMARYAAPRARRSIARRQHSNAAGRAAPQDDGPDMGPRMSERMIWEALD
EGRDPTDREQESDTEGR"
gene 1810240..1811058
/gene="trpC"
/locus_tag="Rv1611"
CDS 1810240..1811058
/codon_start=1
/transl_table=11
/gene="trpC"
/locus_tag="Rv1611"
/product="Probable indole-3-glycerol phosphate synthase
TrpC"
/note="Rv1611, (MTCY01B2.03), len: 272 aa. Probable
trpC,indole-3-glycerol phosphate synthase. Similar to
Q55508|SLR0546 hypothetical 33.0 kDa protein from
synechocystis SP (295 aa), FASTA score: opt: 26, E():
7.6e-32, (44.2% identity in 265 aa overlap); also similar
to TRPC_AZOBR|P26938 ndole-3-glycerol-phosphate
synthaseindole-3-glycerol-phosphate synthase from
Azospirillum brasilense (262 aa), FASTA score: opt:
596,E(): 4.8e-30, (43.8% identity in 258 aa overlap).
Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium
leprae (272 aa) (90.8% identity in 272 aa overlap).
Contains indole-3-glycerol phosphate synthase signature
(PS00614). Belongs to the TrpC family."
/db_xref="EnsemblGenomes-Gn:Rv1611"
/db_xref="EnsemblGenomes-Tr:CCP44375"
/db_xref="GOA:P9WFX7"
/db_xref="InterPro:IPR001468"
/db_xref="InterPro:IPR011060"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR013798"
/db_xref="PDB:3QJA"
/db_xref="PDB:3T40"
/db_xref="PDB:3T44"
/db_xref="PDB:3T55"
/db_xref="PDB:3T78"
/db_xref="PDB:4FB7"
/db_xref="UniProtKB/Swiss-Prot:P9WFX7"
/inference="protein motif:PROSITE:PS00614"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44375.1"
/translation="MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVM
AALREPGIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSL
DDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTES
LGMTALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIA
ESGVRGTADLLAYAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR"
gene 1811127..1812359
/gene="trpB"
/locus_tag="Rv1612"
CDS 1811127..1812359
/codon_start=1
/transl_table=11
/gene="trpB"
/locus_tag="Rv1612"
/product="Tryptophan synthase, beta subunit TrpB"
/note="Rv1612, (MTCY01B2.04), len: 410 aa. TrpB,
tryptophan synthase beta chain. Equivalent to
AL049913|MLCB1610_25 from Mycobacterium leprae (340 aa)
(88.5% identity in 331 aa overlap). Similar to others e.g.
TRPB_CAUCR|P12290 tryptophan synthase beta chain from
Caulobacter crescentus (406 aa), FASTA scores: opt: 1662,
E(): 0, (60.6% identity in 404 aa overlap). Belongs to the
TrpB family. Tetramer of two alpha and two beta chains."
/db_xref="EnsemblGenomes-Gn:Rv1612"
/db_xref="EnsemblGenomes-Tr:CCP44376"
/db_xref="GOA:P9WFX9"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR006653"
/db_xref="InterPro:IPR006654"
/db_xref="InterPro:IPR023026"
/db_xref="InterPro:IPR036052"
/db_xref="PDB:2O2E"
/db_xref="PDB:2O2J"
/db_xref="PDB:5OCW"
/db_xref="PDB:5TCF"
/db_xref="PDB:5TCG"
/db_xref="PDB:5TCH"
/db_xref="PDB:5TCI"
/db_xref="PDB:5TCJ"
/db_xref="PDB:6DU1"
/db_xref="PDB:6DUA"
/db_xref="PDB:6DWE"
/db_xref="PDB:6E9P"
/db_xref="UniProtKB/Swiss-Prot:P9WFX9"
/inference="protein motif:PROSITE:PS00168"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44376.1"
/translation="MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAA
YQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKI
NNVLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDTARQALNV
ARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFGTAAGPHPFPTMVRDF
QRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGV
ETGRHAATFTAGSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAG
RVDYRPITDSEAMDAFGLLCRMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGR
GDKDVETAAKWFGLLGND"
gene 1812359..1813171
/gene="trpA"
/locus_tag="Rv1613"
CDS 1812359..1813171
/codon_start=1
/transl_table=11
/gene="trpA"
/locus_tag="Rv1613"
/product="Probable tryptophan synthase, alpha subunit
TrpA"
/note="Rv1613, (MTCY01B2.05), len: 270 aa. Probable
trpA,tryptophan synthase alpha chain. FASTA best:
O68906|TRPA_MYCIT tryptophan synthase alpha chain from
Mycobacterium intracellulare (271 aa), opt: 1442, E():
0,(85.3% identity in 265 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1613"
/db_xref="EnsemblGenomes-Tr:CCP44377"
/db_xref="GOA:P9WFY1"
/db_xref="InterPro:IPR002028"
/db_xref="InterPro:IPR011060"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR018204"
/db_xref="PDB:5OCW"
/db_xref="PDB:5TCF"
/db_xref="PDB:5TCG"
/db_xref="PDB:5TCH"
/db_xref="PDB:5TCI"
/db_xref="PDB:5TCJ"
/db_xref="PDB:6DU1"
/db_xref="PDB:6DUA"
/db_xref="PDB:6DWE"
/db_xref="PDB:6E9P"
/db_xref="UniProtKB/Swiss-Prot:P9WFY1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44377.1"
/translation="MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAA
MTALVESGCDIIEVGVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAGGR
AVVMTYWNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASEEHRLDRIFLV
APSSTPERLAATVEASRGFVYAASTMGVTGARDAVSQAAPELVGRVKAVSDIPVGVGL
GVRSRAQAAQIAQYADGVIVGSALVTALTEGLPRLRALTGELAAGVRLGMSA"
gene 1813171..1814577
/gene="lgt"
/locus_tag="Rv1614"
CDS 1813171..1814577
/codon_start=1
/transl_table=11
/gene="lgt"
/locus_tag="Rv1614"
/product="Possible prolipoprotein diacylglyceryl
transferases Lgt"
/note="Rv1614, (MTCY01B2.06), len: 468 aa. Possible
lgt,prolipoprotein diacylglyceryl transferases, similar to
many prolipoprotein diacylglyceryl transferases. FASTA
scores: LGT_STAAU|P52282 prolipoprotein diacylglyceryl
transferase from Staphylococcus aureus subsp. (279 aa),
opt: 289,E():3.6e- 09, (31.5% identity in 257 aa overlap);
AL096884|SC4G6_3 cosmid 4G6 from Streptomyces coelicolor
(343 aa), opt: 735, E(): 4e-32, (46.5% identity in 391 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1614"
/db_xref="EnsemblGenomes-Tr:CCP44378"
/db_xref="GOA:P9WK93"
/db_xref="InterPro:IPR001640"
/db_xref="UniProtKB/Swiss-Prot:P9WK93"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44378.1"
/translation="MRMLPSYIPSPPRGVWYLGPLPVRAYAVCVITGIIVALLIGDRR
LTARGGERGMTYDIALWAVPFGLIGGRLYHLATDWRTYFGDGGAGLAAALRIWDGGLG
IWGAVTLGVMGAWIGCRRCGIPLPVLLDAVAPGVVLAQAIGRLGNYFNQELYGRETTM
PWGLEIFYRRDPSGFDVPNSLDGVSTGQVAFVVQPTFLYELIWNVLVFVALIYIDRRF
IIGHGRLFGFYVAFYCAGRFCVELLRDDPATLIAGIRINSFTSTFVFIGAVVYIILAP
KGREAPGALRGSEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVK
AEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQVDAE
AASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDDPAEPDGIRRQ
DDFSSRRRRWWRLRRRRQ"
gene 1815253..1815693
/locus_tag="Rv1615"
CDS 1815253..1815693
/codon_start=1
/transl_table=11
/locus_tag="Rv1615"
/product="Probable membrane protein"
/note="Rv1615, (MTCY01B2.07), len: 146 aa. Probable
membrane protein"
/db_xref="EnsemblGenomes-Gn:Rv1615"
/db_xref="EnsemblGenomes-Tr:CCP44379"
/db_xref="GOA:O06132"
/db_xref="InterPro:IPR007829"
/db_xref="UniProtKB/TrEMBL:O06132"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44379.1"
/translation="MGLRPARVVRPARSGMLKGVTDPLQHGAFEPGWQSAPPGYPPPY
PQYPGPGSYFDPFAPYGRHPVTGQPFSDKSKTVAGLLQLLGLFGIAGIGRIYLGHTGL
GIAQLLVGWVTCGLGAVIWGVIDALLILTDKVGDPWGRPLRDGS"
gene 1815683..1816081
/locus_tag="Rv1616"
CDS 1815683..1816081
/codon_start=1
/transl_table=11
/locus_tag="Rv1616"
/product="Conserved membrane protein"
/note="Rv1616, (MTCY01B2.08), len: 132 aa. Conserved
membrane protein, with some similarity to other
hypothetical proteins e.g. AL096884|SC4G6_9 from
Streptomyces coelicolor cosmid 4G6 (148 aa), FASTA scores:
opt: 245, E(): 1.7e-1 0, (36.7% identity in 128 aa
overlap); Q55401|SLL0543 hypothetical 16.5 kDa protein
from synechocystis SP (148 aa), FASTA scores: opt: 225,
E(): 6.5e-10, (35.9% identity in 117 aa overlap). Has
cysteine cluster and contains a rubredoxin signature
(PS00202)."
/db_xref="EnsemblGenomes-Gn:Rv1616"
/db_xref="EnsemblGenomes-Tr:CCP44380"
/db_xref="InterPro:IPR021215"
/db_xref="UniProtKB/TrEMBL:O06133"
/inference="protein motif:PROSITE:PS00202"
/protein_id="CCP44380.1"
/translation="MEASGRQRRYAAAGSVVLLAGALGYIGLVDPHNSNSLYPPCLFK
LLTGWNCPACGGLRMIHDLLHGELAASINDNVFLLVGVPVLASWVLLRRRHGDLALPI
PVMIAVAVAVIAWTVLRNLPGFPLVPTISG"
gene 1816189..1817607
/gene="pykA"
/locus_tag="Rv1617"
CDS 1816189..1817607
/codon_start=1
/transl_table=11
/gene="pykA"
/locus_tag="Rv1617"
/product="Probable pyruvate kinase PykA"
/note="Rv1617, (MTCY01B2.09), len: 472 aa. Probable
pykA,pyruvate kinase. FASTA best: Q46078 pyruvate kinase
from corynebacterium glutamicum (475 aa), opt: 2221, E():
0,(72.2% identity in 468 aa overlap). Belongs to the
pyruvate kinase family. Phosphorylated in vitro by
PknJ|Rv2088 (See Arora et al., 2010)."
/db_xref="EnsemblGenomes-Gn:Rv1617"
/db_xref="EnsemblGenomes-Tr:CCP44381"
/db_xref="GOA:P9WKE5"
/db_xref="InterPro:IPR001697"
/db_xref="InterPro:IPR011037"
/db_xref="InterPro:IPR015793"
/db_xref="InterPro:IPR015795"
/db_xref="InterPro:IPR015806"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR018209"
/db_xref="InterPro:IPR036918"
/db_xref="InterPro:IPR040442"
/db_xref="PDB:5WRP"
/db_xref="PDB:5WS8"
/db_xref="PDB:5WS9"
/db_xref="PDB:5WSA"
/db_xref="PDB:5WSB"
/db_xref="PDB:5WSC"
/db_xref="UniProtKB/Swiss-Prot:P9WKE5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44381.1"
/translation="MTRRGKIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDH
KVAYERVRVASDATGRAVGVLADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSH
DRVSTTYKRLAQDAVAGDRVLVDDGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLP
GMNVTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAK
LEKPEAIDNLEAIVLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVAT
QMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVE
ENSTAAPPLTHIPRTKRGVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPL
LAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAG
APPGTVGSTNLIHVHRIGEDDV"
gene 1817615..1818517
/gene="tesB1"
/locus_tag="Rv1618"
CDS 1817615..1818517
/codon_start=1
/transl_table=11
/gene="tesB1"
/locus_tag="Rv1618"
/product="Probable acyl-CoA thioesterase II TesB1"
/note="Rv1618, (MTCY01B2.10), len: 300 aa. Probable
tesB1,acyl-CoA thioesterase II, similar to other acyl-CoA
thioesterases e.g. TESB_ECOLI|P23911 acyl-CoA thioesterase
II from Escherichia coli (285 aa), FASTA scores: opt:
495,E(): 2.9e-27, (32.5% identity in 283 aa overlap); etc.
Also similar to Rv2605c|tesB2 from M. tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv1618"
/db_xref="EnsemblGenomes-Tr:CCP44382"
/db_xref="GOA:O06135"
/db_xref="InterPro:IPR003703"
/db_xref="InterPro:IPR025652"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR042171"
/db_xref="UniProtKB/TrEMBL:O06135"
/protein_id="CCP44382.1"
/translation="MPDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQL
MAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAKDIEFQVIRLRDERRFANRRVDAVQ
DGTLLSSAMVSYMAGGRGHEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPI
EWRYANDPAWIMRDKGDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITT
HGLSWGFDRIFAASANHSVWFHRQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKL
IATVVQEGVLKYFPATPDSAAGRS"
gene 1818575..1820029
/locus_tag="Rv1619"
CDS 1818575..1820029
/codon_start=1
/transl_table=11
/locus_tag="Rv1619"
/product="Conserved membrane protein"
/note="Rv1619, (MTCY01B2.11), len: 484 aa. Conserved
membrane protein. Some similarity to N-terminus of
P94974|Rv1640c|MTCY06H11.04c probable lysyl-tRNA
synthetase 2 from Mycobacterium tuberculosis (1172 aa),
FASTA scores: E(): 1.4e-16, (28.0% identity in 410 aa
overlap); and similar in part to O69916| SC3C8.03C
Putative intergral membrane protein from Streptomyces
coelicolor cosmid 3C8 (589 aa), FASTA scores: opt: 453
E(): 8.4e-22, (31.3% identity in 313 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1619"
/db_xref="EnsemblGenomes-Tr:CCP44383"
/db_xref="GOA:O06136"
/db_xref="InterPro:IPR024320"
/db_xref="UniProtKB/TrEMBL:O06136"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44383.1"
/translation="MVAAAGEPLNCQRANPEVTVKLPSADVVPRLRGRQRVVVHVDSR
TARCVGALALVCAACWLIALLAGDYRHAQWAVAGRLGWSLTVLAAVAFIARGIFLGRP
VTAMHATAAGLFLLAGLAAHVLVADLLGEILIAGSGWALMWPTSAHPRPEDLPRVWAL
INATRADSLAPFAMQAGKSHHFSAAGTAALAYRTRIGYAVVSGDPIGDEAQFPQLVAD
FAAMCHMHGWRIVVVGCSERRLGLWSDPMVVGQSLRPIPIGRDVVIDVSNFEMTGRRF
RNLRQAVKRTHNFGVTTEIVAEQQLDDQRQAELAEVLAASPSGARTDRGFCMNLDGVL
EGRYPGIQLIIARDASGRVQGFHRYATAGGGSDMSLDVPWRRRGAPNGIDERLSADMI
AAAKDAGVQRLSLAFAAFPDLFGANQLGRLQRVCRALIHILDPLIALESLYRYLRKFH
ALDERRYVLISMTQVFALALVLLSLEFVPRRRHL"
gene complement(1819963..1821693)
/gene="cydC"
/locus_tag="Rv1620c"
CDS complement(1819963..1821693)
/codon_start=1
/transl_table=11
/gene="cydC"
/locus_tag="Rv1620c"
/product="Probable 'component linked with the assembly of
cytochrome' transport transmembrane ATP-binding protein
ABC transporter CydC"
/note="Rv1620c, (MTCY01B2.12c), len: 576 aa. Probable
cydC,transmembrane ATP-binding protein ABC transporter
involved in transport of component linked with the
assembly of cytochrome (see citation below), similar to
others e.g. CYDC_ECOLI|P23886 transport ATP-binding
protein from Escherichia coli (573 aa), FASTA scores: opt:
631, E(): 1.6e-30, (28.5% identity in 569 aa overlap);
C-terminal part of AL034355|SCD78_14 from Streptomyces
coelicolor (1172 aa), FASTA scores: opt: 956, E(): 0,
(38.8% identity in 554 aa overlap); etc. Contains
(PS00211) ABC transporters family signature, and (PS00017)
ATP/GTP-binding site motif A (P-loop). Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1620c"
/db_xref="EnsemblGenomes-Tr:CCP44384"
/db_xref="GOA:O06137"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR014223"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="UniProtKB/TrEMBL:O06137"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44384.1"
/translation="MNRPSAVSRRQRDLLAASGLLGPRLPRILAAVALGVLSLGSALA
LAGVSAWLITRAWQMPPVLDLSVAVVAVRAFAISRGVLHYCERLATHDTALRAAGRAR
TLIYHRLAHGPAAAAVGLHSGDLAARVGADVDELANMLVRALVPIAVAAVLAVAATAV
VAAVSVPAAVVLAVCLLVAGVVAPWLAGRTAAAQEAIARQHRGMRDTSAMIALEHAPE
LRVAGALRNVIADSQRRQHAWADALDAAARTGAIAEAMPTAAIGASLLGAVVAGIGMA
PTVAPTTLAILMLLPLSAFEATVALPAAAVQLTRSRIAAARLLDLTGSNRVRETESTV
SARLPVGTGVLAADVCCGHQEAQSIRVTIDLPPGARLAVTGASGAGKTTLLMTLAGLL
PPVHGRVLLDGTNLSDFDEDELRSAVSFFAEDAHIFATTVRDNLLTARGDCPDDELIE
ALDRVGLCGWLAGLPEGLSTVLIGGAQAVSAGQRRRLLLARAVLSPARIVLLDEPVEH
LDAANADLLRDLLAPNSGIMSAMRTVVVATHHLPNDIQCAELSIATDQRCRRRGTNSS
DNNTNASAKT"
gene complement(1821690..1823273)
/gene="cydD"
/locus_tag="Rv1621c"
CDS complement(1821690..1823273)
/codon_start=1
/transl_table=11
/gene="cydD"
/locus_tag="Rv1621c"
/product="Probable 'component linked with the assembly of
cytochrome' transport transmembrane ATP-binding protein
ABC transporter CydD"
/note="Rv1621c, (MTCY01B2.13c), len: 527 aa. Probable
cydD,transmembrane ATP-binding protein ABC transporter
involved in transport of component linked with the
assembly of cytochrome (see citation below), similar to
others e.g. P94366|CYDC_BACSU transport ATP-binding
protein from Bacillus subtilis (567 aa), FASTA scores:
opt: 784, E(): 0,(30.1% identity in 535 aa overlap);
N-terminal part of AL034355|SCD78_14 from Streptomyces
coelicolor (1172 aa),FASTA scores: opt: 1295, E(): 0,
(44.6% identity in 534 aa overlap); etc. Also similar to
Q11019|Y07D_MYCTU from Mycobacterium tuberculosis (579
aa), FASTA scores: opt: 530, E(): 6.9e-25, (29.1% identity
in 530 aa overlap). Contains (PS00211) ABC transporters
family signature, and (PS00017) ATP/GTP-binding site motif
A (P-loop). Belongs to the ATP-binding transport protein
family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1621c"
/db_xref="EnsemblGenomes-Tr:CCP44385"
/db_xref="GOA:O06138"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR014216"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="InterPro:IPR039421"
/db_xref="UniProtKB/TrEMBL:O06138"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44385.1"
/translation="MACGVGISGCAIGSAIVLASIVAGVIDPANPGMAGLRRWLGPLS
ILLVLWGLRASIQWLQARLAQRGASAVIADLSGQVLTAVTARRPSQLAAQRDAAAVLI
TRGLDGLRPYFTGYLPTLLLAAILTPATVAVIGLYDLKSMAIVVITLPLIPIFMVLIG
LATTNPSAAALAAMTAVQARLLDLIAGIPTLRALGRASGPEQRIAELSADHRRSAMAT
LRIAFLSALVLELLATLGVALVAVGIGLRLVFGEMSLTAGLTVLLLAPEVYWPLRRVG
VQFHAAADGRTAADKAFALLGESPSPTPGRRTVTARGGVIRLERLSVRGRDGRAPYDL
TADIEPGRVTVLTGRNGAGKSTTLQAIAGLTAPSSGRITVAGVDVTNLAPAAWWRQLS
WLPQRPVLVPGTVRHNLVLLGPVDDLERACAAAGFDAVLDELPRGLDTVLGRGGVGLS
LGQRQRLGLARALGSPAAVLLLDEPTAHLDARTEQHVLGAIVERARAGATVLVVAHRQ
QVAAAGDRVVEVNSDGFRR"
gene complement(1823360..1824400)
/gene="cydB"
/locus_tag="Rv1622c"
CDS complement(1823360..1824400)
/codon_start=1
/transl_table=11
/gene="cydB"
/locus_tag="Rv1622c"
/product="Probable integral membrane cytochrome D
ubiquinol oxidase (subunit II) CydB (cytochrome BD-I
oxidase subunit II)"
/note="Rv1622c, (MTCY01B2.14c), len: 346 aa. Probable
cydB,cytochrome D ubiquinol oxidase subunit II, integral
membrane protein, similar to others e.g. P11027|CYDB_ECOLI
cytochrome D ubiquinol oxidase subunit II from Escherichia
coli strain K12 (379 aa), FASTA scores: opt: 519, E():
0,(32.3% identity in 372 aa overlap); P94365|CYDB_BACSU
cytochrome D ubiquinol oxidase subunit II from Bacillus
subtilis (338 aa), FASTA scores: opt: 824, E(): 0, (39.5%
identity in 337 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1622c"
/db_xref="EnsemblGenomes-Tr:CCP44386"
/db_xref="GOA:O06139"
/db_xref="InterPro:IPR003317"
/db_xref="UniProtKB/TrEMBL:O06139"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44386.1"
/translation="MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPE
THRRTALNTIGPVWDGNEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRA
VAIEWRGKIDDPKWRTGADFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPD
VLNAYTLLGGLATAGLFSLYGAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLW
TQLAYGKDWTWLVLAVAGCAQAAATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYP
NLVPSTLNPQWSLTIHNASSTPYTLKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAER
IPPPTGLARRAP"
gene complement(1824430..1825887)
/gene="cydA"
/gene_synonym="appC"
/locus_tag="Rv1623c"
CDS complement(1824430..1825887)
/codon_start=1
/transl_table=11
/gene="cydA"
/gene_synonym="appC"
/locus_tag="Rv1623c"
/product="Probable integral membrane cytochrome D
ubiquinol oxidase (subunit I) CydA (cytochrome BD-I
oxidase subunit I)"
/note="Rv1623c, (MTCY01B2.15c), len: 485 aa. Probable cydA
(previously known as appC, but renamed cydA to conform
with Mycobacterium smegmatis nomenclature), cytochrome D
ubiquinol oxidase subunit I, integral membrane
protein,similar to others e.g.
P26459|APPC_ECOLI|CYXA|CBDA|B0978 cytochrome BD-II oxidase
subunit I from Escherichia coli strain K12 (514 aa), FASTA
scores: opt: 870, E(): 0, (35.9% identity in 485 aa
overlap); AL034355|SCD78_12 from Streptomyces coelicolor
(501 aa), FASTA scores: opt: 1099,E(): 0, (48.6% identity
in 510 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1623c"
/db_xref="EnsemblGenomes-Tr:CCP44387"
/db_xref="GOA:L7N662"
/db_xref="InterPro:IPR002585"
/db_xref="UniProtKB/TrEMBL:L7N662"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44387.1"
/translation="MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDN
PAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGLAA
FFFESTFIGLWIFGWNRLPRLVHLACIWIVAIAVNVSAFFIIAANSFMQHPVGAHYNP
TTGRAELSSIVVLLTNNTAQAAFTHTVSGALLTAGTFVAAVSAWWLVRSSTTHADSDT
QAMYRPATILGCWVALAATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSV
LTVGRQNNCDSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNL
FVTYWSFRMMIGLMAIPVLFALIALWLTRGGQIPNQRWFSWLALLTMPAPFLANSAGW
VFTEMGRQPWVVVPNPTGDQLVRLTVKAGVSDHSATVVATSLLMFTLVYAVLAVIWCW
LLKRYIVEGPLEHDAEPAAHGAPRDDEVAPLSFAY"
gene complement(1825998..1826585)
/locus_tag="Rv1624c"
CDS complement(1825998..1826585)
/codon_start=1
/transl_table=11
/locus_tag="Rv1624c"
/product="Probable conserved membrane protein"
/note="Rv1624c, (MTCY01B2.16c), len: 195 aa. Probable
membrane protein, first start taken. Some similarity to
Rv3155 nuoK, NADH dehydrogenase chain K from M.
tuberculosis. Also similar to AAK72093.1|AF196488
hypothetical protein from Mycobacterium smegmatis (205
aa). Identities = 117/195 (60%)."
/db_xref="EnsemblGenomes-Gn:Rv1624c"
/db_xref="EnsemblGenomes-Tr:CCP44388"
/db_xref="GOA:O06141"
/db_xref="InterPro:IPR005325"
/db_xref="UniProtKB/TrEMBL:O06141"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44388.1"
/translation="MCHTAPMEPSPVVSPLPRLLPHLWKSTLASGILSLILGVLVLAW
PGISILVAAMAFGVYLLITGVAQVAFAFSLHVSAGGRILLFISGAASLILAVLAFRHF
GDAVLLLAIWIGIGFIFRGVATTVSAISDPMLPGRGWSIFVGVISLIAGIVVMASPFE
SIWILALVVGIWLVVIGTCEIASSFAIRKASQTLG"
gene complement(1826614..1827945)
/gene="cya"
/locus_tag="Rv1625c"
CDS complement(1826614..1827945)
/codon_start=1
/transl_table=11
/gene="cya"
/locus_tag="Rv1625c"
/product="Membrane-anchored adenylyl cyclase Cya (ATP
pyrophosphate-lyase) (adenylate cyclase)"
/note="Rv1625c, (MT1661, MTCY01B2.17c), len: 443 aa.
Cya,membrane-anchored adenylyl cyclase (see citations
below). C-terminal half is similar to region in numerous
eukaryotic adenylate and guanylate cyclases. N-terminal
half hydrophobic. FASTA score: CYG2_RAT|P22717 guanylate
cyclase soluble, beta-2 chain (682 aa), FASTA scores: opt:
552,E(): 2.7e-26, (40.3% identity in 226 aa overlap). Some
similarity to Rv2435c|MTCY428.11 from Mycobacterium
tuberculosis (730 aa), E(): 7e-19. Start changed since
first submission (+25 aa). Belongs to adenylyl cyclase
class-4/guanylyl cyclase family."
/db_xref="EnsemblGenomes-Gn:Rv1625c"
/db_xref="EnsemblGenomes-Tr:CCP44389"
/db_xref="GOA:P9WQ35"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR018297"
/db_xref="InterPro:IPR029787"
/db_xref="PDB:1YK9"
/db_xref="PDB:4P2F"
/db_xref="PDB:4P2M"
/db_xref="PDB:4P2X"
/db_xref="UniProtKB/Swiss-Prot:P9WQ35"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44389.1"
/translation="MAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARR
QRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAP
LTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLV
IALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDR
SEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFL
DRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLK
DPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEV
YERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV"
gene complement(1828015..1828088)
/gene="leuV"
tRNA complement(1828015..1828088)
/gene="leuV"
/product="tRNA-Leu"
/anticodon=(pos:complement(1828052..1828054),aa:Leu,
seq:caa)
/note="codon recognized: UUG; leuV, tRNA-Leu, anticodon
caa, length = 74"
gene 1828180..1828797
/locus_tag="Rv1626"
CDS 1828180..1828797
/codon_start=1
/transl_table=11
/locus_tag="Rv1626"
/product="Probable two-component system transcriptional
regulator"
/note="Rv1626, (MTCY01B2.18), len: 205 aa. Probable
two-component response system transcriptional
regulator,similar to many e.g. CHEY_BACSU|P24072
chemotaxis protein chey homolog (119 aa), FASTA scores:
opt: 283, E(): 1.6e-16, (43.0% identity in 114 aa
overlap). Also similar to AL109732|SC7H2_27 hypothetical
protein from Streptomyces coelicolor (218 aa), opt: 880,
E(): 0, (69.4% identity in 196 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1626"
/db_xref="EnsemblGenomes-Tr:CCP44390"
/db_xref="GOA:P9WGM3"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR005561"
/db_xref="InterPro:IPR008327"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR036388"
/db_xref="PDB:1S8N"
/db_xref="PDB:1SD5"
/db_xref="UniProtKB/Swiss-Prot:P9WGM3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44390.1"
/translation="MTGPTTDADAAVPRRVLIAEDEALIRMDLAEMLREEGYEIVGEA
GDGQEAVELAELHKPDLVIMDVKMPRRDGIDAASEIASKRIAPIVVLTAFSQRDLVER
ARDAGAMAYLVKPFSISDLIPAIELAVSRFREITALEGEVATLSERLETRKLVERAKG
LLQTKHGMTEPDAFKWIQRAAMDRRTTMKRVAEVVLETLGTPKDT"
gene complement(1828865..1830073)
/locus_tag="Rv1627c"
CDS complement(1828865..1830073)
/codon_start=1
/transl_table=11
/locus_tag="Rv1627c"
/product="Probable nonspecific lipid-transfer protein"
/note="Rv1627c, (MTCY01B2.19c), len: 402 aa. Probable
nonspecific lipid-transfer protein, similar to many lipid
carrier proteins e.g. Q51797 acetyl CoA synthase from
Pyrococcus furiosus (388 aa), FASTA scores: opt: 400, E():
3.2e-18, (34.4% identity in 407 aa overlap); etc. Also
some similarity to Mycobacterium tuberculosis proteins
Rv3523,Rv3540c, Rv0244, Rv2790c, Rv1323, etc."
/db_xref="EnsemblGenomes-Gn:Rv1627c"
/db_xref="EnsemblGenomes-Tr:CCP44391"
/db_xref="GOA:O06144"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020616"
/db_xref="UniProtKB/TrEMBL:O06144"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44391.1"
/translation="MRMSAPEPVYILGAGMHPWGKWGNDFTEYGVVAARAALRDAGVD
WRHVQLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSARAQI
LAGFCDVALVIGADTTPKGFFAPVGGERKGDPDWQRFHLIGATNTVYFALLARRRMDL
YGATVEDFAQVKVKNSRHGLDNPNARYRKENSIDDVLASPVVSDPLRLLDICATSDGA
AALIVASKSFTEKHLGSVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERV
FKDQILDAAYAEAGIGPEDLSLAEVYDLSTALELDWYEHLGLCPKGEAEALLRSGATT
LGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVADAKVGVTANQGLF
GHGSSVIVAR"
gene complement(1830070..1830561)
/locus_tag="Rv1628c"
CDS complement(1830070..1830561)
/codon_start=1
/transl_table=11
/locus_tag="Rv1628c"
/product="Conserved protein"
/note="Rv1628c, (MTCY01B2.20c), len: 163 aa. Conserved
protein, some similarity to others e.g. Q51796 ACAC
protein in Pyrococcus furiosus (136 aa), FASTA scores:
opt: 199,E(): 4.6e-06, (34.7% identity in 121 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1628c"
/db_xref="EnsemblGenomes-Tr:CCP44392"
/db_xref="InterPro:IPR002878"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR022002"
/db_xref="UniProtKB/TrEMBL:O06145"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44392.1"
/translation="MPEVTREEPAIDGWFTTDKAGNPHLLGGKCPQCGTYVFPPRADN
CPNPACGSDTLESVGLSTRGKLWSYTENRYAPPPPYPAPDPFEPFAVAAVELADEGLI
VLGKVVDGTLAADLKVGMEMELTTMPLFADDDGVQRIVYAWRIPSRAGDDAERSDAEE
RRR"
repeat_region complement(1830074..1830125)
/locus_tag="Rv1628c"
/note="52 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 1830665..1833379
/gene="polA"
/locus_tag="Rv1629"
CDS 1830665..1833379
/codon_start=1
/transl_table=11
/gene="polA"
/locus_tag="Rv1629"
/product="Probable DNA polymerase I PolA"
/note="Rv1629, (MTCY01B2.21), len: 904 aa. Probable
polA,DNA polymerase I (see citations below). Has DNA
polymerase family a signature (PS00447) at C-terminal end.
FASTA best: DPO1_MYCTU|Q07700 DNA polymerase I from
Mycobacterium tuberculosis (904 aa). Some similarity to
Rv2090|MTCY49.30 (393 aa), E(): 2.2e-18, (38.7% identity
in 292 aa overlap). Belongs to DNA polymerase type-a
family."
/db_xref="EnsemblGenomes-Gn:Rv1629"
/db_xref="EnsemblGenomes-Tr:CCP44393"
/db_xref="GOA:P9WNU5"
/db_xref="InterPro:IPR001098"
/db_xref="InterPro:IPR002298"
/db_xref="InterPro:IPR002421"
/db_xref="InterPro:IPR002562"
/db_xref="InterPro:IPR008918"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR018320"
/db_xref="InterPro:IPR019760"
/db_xref="InterPro:IPR020045"
/db_xref="InterPro:IPR020046"
/db_xref="InterPro:IPR029060"
/db_xref="InterPro:IPR036279"
/db_xref="InterPro:IPR036397"
/db_xref="UniProtKB/Swiss-Prot:P9WNU5"
/inference="protein motif:PROSITE:PS00447"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44393.1"
/translation="MVTTASAPSEDRAKPTLMLLDGNSLAFRAFYALPAENFKTRGGL
TTNAVYGFTAMLINLLRDEAPTHIAAAFDVSRQTFRLQRYPEYKANRSSTPDEFAGQI
DITKEVLGALGITVLSEPGFEADDLIATLATQAENEGYRVLVVTGDRDALQLVSDDVT
VLYPRKGVSELTRFTPEAVVEKYGLTPRQYPDFAALRGDPSDNLPGIPGVGEKTAAKW
IAEYGSLRSLVDNVDAVRGKVGDALRANLASVVRNRELTDLVRDVPLAQTPDTLRLQP
WDRDHIHRLFDDLEFRVLRDRLFDTLAAAGGPEVDEGFDVRGGALAPGTVRQWLAEHA
GDGRRAGLTVVGTHLPHGGDATAMAVAAADGEGAYLDTATLTPDDDAALAAWLADPAK
PKALHEAKAAVHDLAGRGWTLEGVTSDTALAAYLVRPGQRSFTLDDLSLRYLRRELRA
ETPQQQQLSLLDDDDTDAETIQTTILRARAVIDLADALDAELARIDSTALLGEMELPV
QRVLAKMESAGIAVDLPMLTELQSQFGDQIRDAAEAAYGVIGKQINLGSPKQLQVVLF
DELGMPKTKRTKTGYTTDADALQSLFDKTGHPFLQHLLAHRDVTRLKVTVDGLLQAVA
ADGRIHTTFNQTIAATGRLSSTEPNLQNIPIRTDAGRRIRDAFVVGDGYAELMTADYS
QIEMRIMAHLSGDEGLIEAFNTGEDLHSFVASRAFGVPIDEVTGELRRRVKAMSYGLA
YGLSAYGLSQQLKISTEEANEQMDAYFARFGGVRDYLRAVVERARKDGYTSTVLGRRR
YLPELDSSNRQVREAAERAALNAPIQGSAADIIKVAMIQVDKALNEAQLASRMLLQVH
DELLFEIAPGERERVEALVRDKMGGAYPLDVPLEVSVGYGRSWDAAAH"
gene 1833542..1834987
/gene="rpsA"
/locus_tag="Rv1630"
CDS 1833542..1834987
/codon_start=1
/transl_table=11
/gene="rpsA"
/locus_tag="Rv1630"
/product="30S ribosomal protein S1 RpsA"
/note="Rv1630, (MTCY01B2.22), len: 481 aa. rpsA, 30S
ribosomal protein S1. FASTA best: RS1_MYCLE|P46836 30s
ribosomal protein S1 from Mycobacterium leprae (482
aa),opt: 2655, E(): 0, (87.2% identity in 483 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1630"
/db_xref="EnsemblGenomes-Tr:CCP44394"
/db_xref="GOA:P9WH43"
/db_xref="InterPro:IPR003029"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR022967"
/db_xref="PDB:4NNG"
/db_xref="PDB:4NNI"
/db_xref="PDB:4NNK"
/db_xref="UniProtKB/Swiss-Prot:P9WH43"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44394.1"
/translation="MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIV
KVDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLIL
SKKRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRD
LQPYIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSS
IVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSL
KATQEDPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVP
DQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPAKYGMADSYDEQGNYIF
PEGFDAETNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAEAAGRGADDQSS
ASSAPSEKTAGGSLASDAQLAALREKLAGSA"
gene 1835013..1836236
/gene="coaE"
/locus_tag="Rv1631"
CDS 1835013..1836236
/codon_start=1
/transl_table=11
/gene="coaE"
/locus_tag="Rv1631"
/product="Probable dephospho-CoA kinase CoaE
(dephosphocoenzyme a kinase)"
/note="Rv1631, (MTCY01B2.23), len: 407 aa. Probable
coaE,dephospho-CoA kinase, similar to many e.g.
Q50178|ML1383|COAE_MYCLE dephospho-CoA kinase from
Mycobacterium leprae (410 aa), FASTA scores: E(): 0,
(77.5% identity in 409 aa overlap). Has ATP/GTP-binding
site motif A (P-loop, PS00017) at N-terminus. In the
N-terminal section; belongs to the CoaE family. In the
C-terminal section; belongs to the UPF0157 (GrpB) family."
/db_xref="EnsemblGenomes-Gn:Rv1631"
/db_xref="EnsemblGenomes-Tr:CCP44395"
/db_xref="GOA:P9WPA3"
/db_xref="InterPro:IPR001977"
/db_xref="InterPro:IPR007344"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WPA3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44395.1"
/translation="MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTE
GLASLVDAFGRDILLADGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIAAV
SGDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQA
SDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADP
SWPDQARRIVNRLKIACGHKALRVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADE
LAEPLLAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKRVHASADPGRPTNVH
LRVHGWPNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDA
YQRAWEWADAVHWRP"
gene complement(1836387..1836830)
/locus_tag="Rv1632c"
CDS complement(1836387..1836830)
/codon_start=1
/transl_table=11
/locus_tag="Rv1632c"
/product="Hypothetical protein"
/note="Rv1632c, (MTCY01B2.24c), len: 147 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1632c"
/db_xref="EnsemblGenomes-Tr:CCP44396"
/db_xref="InterPro:IPR007295"
/db_xref="InterPro:IPR014465"
/db_xref="InterPro:IPR035930"
/db_xref="UniProtKB/TrEMBL:O06149"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44396.1"
/translation="MRAVDEYTVHPWGLYLARPTPGRAQFHYLESWLLPSLGLRATVF
HFNPSHKRDHDYYLDVGEYTPGPSVWRSEDHYLDIEVRTGGGAELADVDELLDAVRHG
LLTPTVAEQAVRHAVDAVEGLARNGYDLTRWLATKGMELTWRSGS"
gene 1837075..1839171
/gene="uvrB"
/locus_tag="Rv1633"
CDS 1837075..1839171
/codon_start=1
/transl_table=11
/gene="uvrB"
/locus_tag="Rv1633"
/product="Probable excinuclease ABC (subunit B-helicase)
UvrB"
/note="Rv1633, (MTCY01B2.25), len: 698 aa. Probable
uvrB,excinuclease ABC, subunit B; helicase (see Mizrahi &
Andersen 1998; Sancar 1994); has ATP/GTP-binding site
motif A (P-loop; PS00017) near N-terminus (see citation
below). FASTA best: UVRB_MICLU|P10125 from Micrococcus
luteus (709 aa), opt: 3268, E(): 0, (71.3% identity in 704
aa overlap). Also similar to Mycobacterium tuberculosis
Rv2973c (recG); and Rv1020 (mfd). Belongs to the UVRB
family."
/db_xref="EnsemblGenomes-Gn:Rv1633"
/db_xref="EnsemblGenomes-Tr:CCP44397"
/db_xref="GOA:P9WFC7"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR001943"
/db_xref="InterPro:IPR004807"
/db_xref="InterPro:IPR006935"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR024759"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036876"
/db_xref="InterPro:IPR041471"
/db_xref="UniProtKB/Swiss-Prot:P9WFC7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44397.1"
/translation="MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATG
TGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEA
YIAQTDTYIEKDSSINDDVERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRS
VELKVGEEVPRDGLLRLLVDVQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFF
GDEIEALYYLHPLTGEVIRQVDSLRIFPATHYVAGPERMAHAVSAIEEELAERLAELE
SQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDF
LLVIDESHVTVPQIGGMYEGDISRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVY
LSATPGPYELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRTRADADQRV
LVTTLTKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGDYDVLVGINLLR
EGLDLPEVSLVAILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADKITDSMREAI
DETERRRAKQIAYNEANGIDPQPLRKKIADILDQVYREADDTAVVEVGGSGRNASRGR
RAQGEPGRAVSAGVFEGRDTSAMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEI
ADLKRELRGMDAAGLK"
gene 1839168..1840583
/locus_tag="Rv1634"
CDS 1839168..1840583
/codon_start=1
/transl_table=11
/locus_tag="Rv1634"
/product="Possible drug efflux membrane protein"
/note="Rv1634, (MTCY01B2.26), len: 471 aa. Possible drug
efflux membrane protein of major facilitator superfamily
(MFS), similar to many antibiotic resistance (efflux)
proteins. FASTA best: Q56175 TU22 dTDP-glucose
dehydrtatase (GRAE) from Streptomyces violaceoruber (557
aa), opt: 415,E(): 1.7e-17, (26.7% identity in 446 aa
overlap). Relatives in Mycobacterium tuberculosis:
MTCY369.27c, E(): 4.8e-12; MTCY20B11.14c, E(): 2.9e-10."
/db_xref="EnsemblGenomes-Gn:Rv1634"
/db_xref="EnsemblGenomes-Tr:CCP44398"
/db_xref="GOA:P9WJX3"
/db_xref="InterPro:IPR001411"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJX3"
/protein_id="CCP44398.1"
/translation="MTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLP
STIADIGGSRLYAWVTTLYLVGSVVAATTVNTMLLRVGARSSYLMGLAVFGLASLVCA
AAPSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGP
ATGGLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSL
LLMGAAALAISVAALPNYLVQTAGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPL
KWIYLTMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVGWTVGEVASASLNS
ARVIGHVVAAAPLVMASGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTV
RAMDSVADPAESSAAAAAINVVQLISGAFGAGLAGVVVNTAKGGEVAAARGLYMAFTV
LAAAGVIASYQATHRDRRLPR"
gene complement(1840572..1842242)
/locus_tag="Rv1635c"
CDS complement(1840572..1842242)
/codon_start=1
/transl_table=11
/locus_tag="Rv1635c"
/product="Probable mannosyltransferase. Probable conserved
transmembrane protein."
/note="Rv1635c, (MTCY01B2.27c), len: 556 aa. Probable
mannosyltransferase (See Dinadayala et al., 2006).
Predicted to be in the GT-C superfamily of
glycosyltransferases (See Liu and Mushegian, 2003).
Probable conserved transmembrane protein, equivalent to
CAC31770.1|AL583921 Mycobacterium leprae membrane protein
(527 aa), Identities = 332/527 (62%). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1635c"
/db_xref="EnsemblGenomes-Tr:CCP44399"
/db_xref="GOA:O06152"
/db_xref="InterPro:IPR038731"
/db_xref="UniProtKB/TrEMBL:O06152"
/protein_id="CCP44399.1"
/translation="MHASRPGAPPHAGLPSRRTAGDQDHRADPKVTRIMSASTLEQPA
AAHVDELVARMRGRLLDPLAIAVLAAVISGAWASRPSLWFDEGATISASASRTLPELW
SLLGHIDAVHGLYYLLMHGWFAIFPPTELWSRLPSCLAIGAAAAGVVVFAKQFSGRTT
AVCAGAVFAILPRVTWAGIEARSSALSVAAAVWLTVLLVAAVRCNTQRRWLLYALVLM
LSILVSINLALLVPAYATMVPLLASGKSRKSPVIWWTVVTAAALGAMTPFILFAHGQV
WQVGWIAGLNRNIILDVIHRQYFDHSVPFAILAGLIVAAGIAAHLAGARGPGGDTHRL
VLVSAAWIVVPTAVVLIYSATVEPIYYPRYLILTAPAAAVILAVCVVTIARKPWLIAG
VVFLLAAAAFPNYFFTQRGPYAKEGWDYSQVADVISAHAKPGDCLLVDNTAGWRPGPI
RALLATRPAAFRSLIDVERGTYGPKVGTLWDGHVAVWLTTAKIDKCPTLWTIANRDKS
LPDHQVGEMLSPGTGFGRTPVYRFPSYLGFRIVERWQFHYSQVVKSTR"
gene 1842451..1842891
/gene="TB15.3"
/locus_tag="Rv1636"
CDS 1842451..1842891
/codon_start=1
/transl_table=11
/gene="TB15.3"
/locus_tag="Rv1636"
/product="Iron-regulated universal stress protein family
protein TB15.3"
/note="Rv1636, (MTCY01B2.28), len: 146 aa.
TB15.3,iron-regulated universal stress protein family
protein (see citations below), similar to other
hypothetical proteins from diverse organisms e.g.
Q57951|MJ0531|Y531_METJA from Methanococcus jannaschii
(170 aa), FASTA scores: opt: 188,E(): 6e-06, (32.2%
identity in 149 aa overlap); also P42297|YXIE_BACSU
hypothetical 15.9 kDa protein in bglh-wapa intergenic
region precursor from Bacillus subtilis (148 aa), FASTA
scores: opt: 162, E(): 0.00025,(30.8% identity in 156 aa
overlap). Part of family of Mycobacterium tuberculosis
hypothetical proteins (but lacks C-terminal region)
including Rv2005c, Rv2623, Rv2026c,Rv1996, etc."
/db_xref="EnsemblGenomes-Gn:Rv1636"
/db_xref="EnsemblGenomes-Tr:CCP44400"
/db_xref="GOA:P9WFC9"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="InterPro:IPR014729"
/db_xref="PDB:1TQ8"
/db_xref="UniProtKB/Swiss-Prot:P9WFC9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44400.1"
/translation="MSAYKTVVVGTDGSDSSMRAVDRAAQIAGADAKLIIASAYLPQH
EDARAADILKDESYKVTGTAPIYEILHDAKERAHNAGAKNVEERPIVGAPVDALVNLA
DEEKADLLVVGNVGLSTIAGRLLGSVPANVSRRAKVDVLIVHTT"
gene complement(1842898..1843692)
/locus_tag="Rv1637c"
CDS complement(1842898..1843692)
/codon_start=1
/transl_table=11
/locus_tag="Rv1637c"
/product="Conserved protein"
/note="Rv1637c, (MTCY01B2.29c,MTCY06H11.01c), len: 264 aa.
Conserved protein, some similarity to others e.g.
P05446|GLO2_RHOBL probable hydroxyacylglutathione
hydrolase (255 aa), FASTA scores: opt: 252, E(): 2e-09,
(39.0% identity in 146 aa overlap). Also similar to
Q9Z505|AL035591|SCC54.20 putative hydrolase from
Streptomyces coelicolor (218 aa), FASTA scores: opt:
732,E(): 0, (52.3% identity in 220 aa overlap). Also
similar to Mycobacterium tuberculosis hypothetical
proteins and putative glyoxylases e.g. Rv0634c, Rv3677c,
Rv2581c,Rv2260."
/db_xref="EnsemblGenomes-Gn:Rv1637c"
/db_xref="EnsemblGenomes-Tr:CCP44401"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:O06154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44401.1"
/translation="MLCARTDNHQGTGNVVTSAHMTRANDDDAGAAGIGAVAHMTTVD
DNYTGHVERGKAARRFLPGATILKASVGPMDNNAYLVTCSATGETLLIDAANDAEVLI
DLVRRYAPKLALIVTSHQHFDHWQALQAVAAATGAPTAAHPIDADPLPVKPDRLLTHG
DSVRIGELTFDVIHLRGHTPGSIALALGGPVTGGVTQLFTGDCLFPGGVGKTWQPADF
TQLLDDVTTRVFDVYADSTVIYPGHGDDTELGAERPSLSEWRARGW"
gene 1843741..1846659
/gene="uvrA"
/locus_tag="Rv1638"
CDS 1843741..1846659
/codon_start=1
/transl_table=11
/gene="uvrA"
/locus_tag="Rv1638"
/product="Probable excinuclease ABC (subunit A-DNA-binding
ATPase) UvrA"
/note="Rv1638, (MTCY06H11.01,MTCY06H11.02c), len: 972 aa.
Probable uvrA, excinuclease ABC, subunit A; DNA-binding
ATPase (see citations below), similar to many e.g.
UVRA_ECOLI|P07671 excinuclease abc subunit A from
Escherichia coli (940 aa), FASTA scores: opt: 2573, E():
0,(56.2% identity in 951 aa overlap). Contains 2x PS00017
ATP/GTP-binding site motif A, PS00211 ABC transporters
family signature, PS00211 ABC transporters family
signature. Consists of three subunits; UVRA, UVRB and
UVRC. Belongs to the ABC transporter family. UVRA
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1638"
/db_xref="EnsemblGenomes-Tr:CCP44402"
/db_xref="GOA:P9WQK7"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR004602"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041102"
/db_xref="InterPro:IPR041552"
/db_xref="PDB:3ZQJ"
/db_xref="UniProtKB/Swiss-Prot:P9WQK7"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44402.1"
/translation="MADRLIVKGAREHNLRSVDLDLPRDALIVFTGLSGSGKSSLAFD
TIFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTNRNPRSTVGTI
TEVYDYLRLLYARAGTPHCPTCGERVARQTPQQIVDQVLAMPEGTRFLVLAPVVRTRK
GEFADLFDKLNAQGYSRVRVDGVVHPLTDPPKLKKQEKHDIEVVVDRLTVKAAAKRRL
TDSVETALNLADGIVVLEFVDHELGAPHREQRFSEKLACPNGHALAVDDLEPRSFSFN
SPYGACPECSGLGIRKEVDPELVVPDPDRTLAQGAVAPWSNGHTAEYFTRMMAGLGEA
LGFDVDTPWRKLPAKARKAILEGADEQVHVRYRNRYGRTRSYYADFEGVLAFLQRKMS
QTESEQMKERYEGFMRDVPCPVCAGTRLKPEILAVTLAGESKGEHGAKSIAEVCELSI
ADCADFLNALTLGPREQAIAGQVLKEIRSRLGFLLDVGLEYLSLSRAAATLSGGEAQR
IRLATQIGSGLVGVLYVLDEPSIGLHQRDNRRLIETLTRLRDLGNTLIVVEHDEDTIE
HADWIVDIGPGAGEHGGRIVHSGPYDELLRNKDSITGAYLSGRESIEIPAIRRSVDPR
RQLTVVGAREHNLRGIDVSFPLGVLTSVTGVSGSGKSTLVNDILAAVLANRLNGARQV
PGRHTRVTGLDYLDKLVRVDQSPIGRTPRSNPATYTGVFDKIRTLFAATTEAKVRGYQ
PGRFSFNVKGGRCEACTGDGTIKIEMNFLPDVYVPCEVCQGARYNRETLEVHYKGKTV
SEVLDMSIEEAAEFFEPIAGVHRYLRTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASE
LQKRSTGRTVYILDEPTTGLHFDDIRKLLNVINGLVDKGNTVIVIEHNLDVIKTSDWI
IDLGPEGGAGGGTVVAQGTPEDVAAVPASYTGKFLAEVVGGGASAATSRSNRRRNVSA
"
gene complement(1846716..1846973)
/locus_tag="Rv1638A"
CDS complement(1846716..1846973)
/codon_start=1
/transl_table=11
/locus_tag="Rv1638A"
/product="Conserved hypothetical protein"
/note="Rv1638A, len: 85 aa. Conserved hypothetical
protein,similar to C-terminal part of P31511|35KD_MYCTU
35kd immunogenic protein from Mycobacterium tuberculosis
(270 aa), FASTA scores: opt: 159, E(): 0.002, (50.90%
identity in 55 aa overlap); and to Mycobacterium leprae
ML0981 possible pseudogene, an orthologue of 35kd
immunogenic protein from Mycobacterium tuberculosis. Size
difference suggests possible gene fragment."
/db_xref="EnsemblGenomes-Gn:Rv1638A"
/db_xref="EnsemblGenomes-Tr:CCP44403"
/db_xref="UniProtKB/TrEMBL:L7N673"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44403.1"
/translation="MPDEPTPPEATTPNSESDPRYDSAGVPTFESVREKIETRYGTAL
GATELDAESPQGRRLEDQYAQRQRAAAERLAQIRESMHTDE"
gene complement(1846989..1848458)
/locus_tag="Rv1639c"
CDS complement(1846989..1848458)
/codon_start=1
/transl_table=11
/locus_tag="Rv1639c"
/product="Conserved hypothetical membrane protein"
/note="Rv1639c, (MTCY06H11.03c), len: 489 aa. Conserved
hypothetical membrane protein. Some similarity to
P35866|YLI2_CORGL Hypothetical 45.7 kDa protein from
Corynebacterium glutamicum (426 aa), FASTA scores: opt:
511, E(): 2.4e-23, (28.9% identity in 370 aa overlap).
Contains PS00904 protein phenyltransferases alpha subunit
repeat signature"
/db_xref="EnsemblGenomes-Gn:Rv1639c"
/db_xref="EnsemblGenomes-Tr:CCP44404"
/db_xref="GOA:P94973"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P94973"
/inference="protein motif:PROSITE:PS00904"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44404.1"
/translation="MAQNELVTASTPPAATQPLAVGHTSLMHGWVPLAVQVVTAVVLV
LAAGWRSRHWQRRWLPTAAAIGATLAWGTRWYVTGNGLANERPPSTLWIWVALTGAAA
TVLILGWRSARWWRRGASLLAVPLCLLSATLTLNLWVGYFPTVQTAWNQLTSGPLPDQ
ADQAAVAALAHSGVRPSHGTLLPVVIPSDASHFKHRGELVYLPPAWFDREHRSENPPP
PQLPTVMMIGGQFNTPADWARAGNAVKTLDDFAAAHSGNAPVVVFVDSGGAFNNDTEC
VNGRRGNAADHLTKDVVPYMVSKFGVSPEQTSWGIVGWSMGGTCAVDLTVMHPTLFSA
FVDIAGDFYPNAGNKTQTIVRLFGGNEDAWSAFDPTTVITRHGSYTGLSGWFAISSPG
PPSPDNAVADTTTMRLAGRDAAANPGNQAAAANALCALGRANGIYCAVVPQPGKHDWP
FADRVFAAALPWLAGQLATPGVPKIPLPGTTQQIAGTGR"
gene complement(1848517..1852035)
/gene="lysX"
/locus_tag="Rv1640c"
CDS complement(1848517..1852035)
/codon_start=1
/transl_table=11
/gene="lysX"
/locus_tag="Rv1640c"
/product="Lysyl-tRNA synthetase 2 LysX"
/note="Rv1640c, (MTCY06H11.04c), len: 1172 aa.
lysX,lysyl-tRNA synthetase 2, probable two domain protein.
N-terminal part (bases 1850153 to 1852033) is similar to
AL023861|SC3C8_3 hypothetical membrane protein from
Streptomyces coelicolor (589 aa), Fasta scores: opt:
1426,E(): 0, (44.6% identity in 585 aa overlap). The
C-terminal part is similar to SYK_CRILO|P37879 lysyl-tRNA
synthetases from Cricetulus longicaudatus (Long-tailed
hamster) (597 aa), Fasta scores, opt: 985, E(): 0, (36.8%
identity in 524 aa overlap). Contains PS00179
Aminoacyl-transfer RNA synthetases class-II signature 1,
PS00339 Aminoacyl-transfer RNA synthetases class-II
signature 2. This may indicate a frame shift but sequence
has been checked and no error found. Belongs to class-II
aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv1640c"
/db_xref="EnsemblGenomes-Tr:CCP44405"
/db_xref="GOA:P9WFU7"
/db_xref="InterPro:IPR002313"
/db_xref="InterPro:IPR004364"
/db_xref="InterPro:IPR004365"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR018149"
/db_xref="InterPro:IPR024320"
/db_xref="InterPro:IPR031553"
/db_xref="UniProtKB/Swiss-Prot:P9WFU7"
/inference="protein motif:PROSITE:PS00339"
/inference="protein motif:PROSITE:PS00179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44405.1"
/translation="MGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQ
RAATPGISRLLGISSRSVTLTKPRSATRGNSRYHWVPAAAGWTVGVIATLSLLASVSP
LIRWIIKVPREFINDYLFNFPDTNFAWSFVLALLAAALTARKRIAWLVLLANMVLAAV
VNAAEIAAGGNTAAESFGENLGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLA
GAVVGIVASWGLVELFPGSLAPDERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGL
FGAFALIGAAIVLFLSQRADNALTGEDESAIRGLLDLYGKDDSLGYFATRRDKSVVFA
SSGRACITYRVEVGVCLASGDPVGDHRAWPQAVDAWLRLCQTYGWAPGVMGASSQGAQ
TYREAGLTALELGDEAILRPADFKLSGPEMRGVRQAVTRARRAGLTVRIRRHRDIAED
EMAQTITRADSWRDTETERGFSMALGRLGDPADSDCLLVEAIDPHNQVLAMLSLVPWG
TTGVSLDLMRRSPQSPNGTIELMVSELALHAESLGITRISLNFAVFRAAFEQGAQLGA
GPVARLWRGLLVFFSRWWQLETLYRSNMKYQPEWVPRYACYEDARVIPRVGVASVIAE
GFLVLPFSRRNRVHTGHHPAVPERLAATGLLHHDGSAPDVSGLRQVGLTNGDGVERRL
PEQVRVRFDKLEKLRSSGIDAFPVGRPPSHTVAQALAADHQASVSVSGRIMRIRNYGG
VLFAQLRDWSGEMQVLLDNSRLDQGCAADFNAATDLGDLVEMTGHMGASKTGTPSLIV
SGWRLIGKCLRPLPNKWKGLLDPEARVRTRYLDLAVNAESRALITARSSVLRAVRETL
FAKGFVEVETPILQQLHGGATARPFVTHINTYSMDLFLRIAPELYLKRLCVGGVERVF
ELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLEWIDGCRELIQNAAQAANGAPIAMRP
RTDKGSDGTRHHLEPVDISGIWPVRTVHDAISEALGERIDADTGLTTLRKLCDAAGVP
YRTQWDAGAVVLELYEHLVECRTEQPTFYIDFPTSVSPLTRPHRSKRGVAERWDLVAW
GIELGTAYSELTDPVEQRRRLQEQSLLAAGGDPEAMELDEDFLQAMEYAMPPTGGLGM
GIDRVVMLITGRSIRETLPFPLAKPH"
gene 1852273..1852878
/gene="infC"
/locus_tag="Rv1641"
CDS 1852273..1852878
/codon_start=1
/transl_table=11
/gene="infC"
/locus_tag="Rv1641"
/product="Probable initiation factor if-3 InfC"
/note="Rv1641, (MTCY06H11.05), len: 201 aa. Probable
infC,initiation factor if-3, similar to many e.g.
IF3_BACST|P03000 initiation factor if-3 from Bacillus
stearothermophilus (171 aa), FASTA scores: opt: 560, E():
1.9e-27, (50.6% identity in 166 aa overlap). Note that an
AUC initiation codon has been used, the Bacillus
(IF3_BACSU) and Escherichia coli (IF3_ECOLI) proteins use
an AUU initiation codon, and the Myxococcus xanthus
(DSG_MYXXA) homolog uses a AUC. Belongs to the if-3
family."
/db_xref="EnsemblGenomes-Gn:Rv1641"
/db_xref="EnsemblGenomes-Tr:CCP44406"
/db_xref="GOA:P9WKJ9"
/db_xref="InterPro:IPR001288"
/db_xref="InterPro:IPR019813"
/db_xref="InterPro:IPR019814"
/db_xref="InterPro:IPR019815"
/db_xref="InterPro:IPR036787"
/db_xref="InterPro:IPR036788"
/db_xref="UniProtKB/Swiss-Prot:P9WKJ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44406.1"
/translation="MSTETRVNERIRVPEVRLIGPGGEQVGIVRIEDALRVAADADLD
LVEVAPNARPPVCKIMDYGKYKYEAAQKARESRRNQQQTVVKEQKLRPKIDDHDYETK
KGHVVRFLEAGSKVKVTIMFRGREQSRPELGYRLLQRLGADVADYGFIETSAKQDGRN
MTMVLAPHRGAKTRARARHPGEPAGGPPPKPTAGDSKAAPN"
gene 1852928..1853122
/gene="rpmI"
/locus_tag="Rv1642"
CDS 1852928..1853122
/codon_start=1
/transl_table=11
/gene="rpmI"
/locus_tag="Rv1642"
/product="50S ribosomal protein L35 RpmI"
/note="Rv1642, (MTCY06H11.06), len: 64 aa. rpmI, 50S
ribosomal protein L35, similar to several e.g.
RL35_SYNY3|P48959 from Synechocystis sp. (67 aa), fasta
scores: opt: 179, E(): 2.7e-08, (51.6% identity in 64 aa
overlap). Belongs to the L35P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv1642"
/db_xref="EnsemblGenomes-Tr:CCP44407"
/db_xref="GOA:P9WH91"
/db_xref="InterPro:IPR001706"
/db_xref="InterPro:IPR018265"
/db_xref="InterPro:IPR021137"
/db_xref="InterPro:IPR037229"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH91"
/protein_id="CCP44407.1"
/translation="MPKAKTHSGASKRFRRTGTGKIVRQKANRRHLLEHKPSTRTRRL
DGRTVVAANDTKRVTSLLNG"
gene 1853184..1853573
/gene="rplT"
/locus_tag="Rv1643"
CDS 1853184..1853573
/codon_start=1
/transl_table=11
/gene="rplT"
/locus_tag="Rv1643"
/product="50S ribosomal protein L20 RplT"
/note="Rv1643, (MTCY06H11.07), len: 129 aa. rplT, 50S
ribosomal protein L20, similar to several e.g.
RL20_ECOLI|P02421 from Escherichia coli (117 aa), FASTA
scores: opt: 438, E(): 5.8e-24, (60.3% identity in 116 aa
overlap). Contains PS00937 Ribosomal protein L20
signature."
/db_xref="EnsemblGenomes-Gn:Rv1643"
/db_xref="EnsemblGenomes-Tr:CCP44408"
/db_xref="GOA:P9WHC5"
/db_xref="InterPro:IPR005813"
/db_xref="InterPro:IPR035566"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHC5"
/inference="protein motif:PROSITE:PS00937"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44408.1"
/translation="MARVKRAVNAHKKRRSILKASRGYRGQRSRLYRKAKEQQLHSLN
YAYRDRRARKGEFRKLWIARINAAARLNDITYNRLIQGLKAAGVEVDRKNLADIAISD
PAAFTALVDVARAALPEDVNAPSGEAA"
gene 1853606..1854388
/gene="tsnR"
/locus_tag="Rv1644"
CDS 1853606..1854388
/codon_start=1
/transl_table=11
/gene="tsnR"
/locus_tag="Rv1644"
/product="Possible 23S rRNA methyltransferase TsnR"
/note="Rv1644, (MTCY06H11.08), len: 260 aa. Possible
tsnR,23S rRNA methyltransferase, similar to several e.g.
TSNR_STRLU|P52393 from Streptomyces laurentii (270
aa),FASTA scores: opt: 276, E(): 3.6e-11, (27.6% identity
in 261 aa overlap). Also similar to M. tuberculosis
hypothetical proteins Rv0881, Rv3579c, and Rv0380c."
/db_xref="EnsemblGenomes-Gn:Rv1644"
/db_xref="EnsemblGenomes-Tr:CCP44409"
/db_xref="GOA:P94978"
/db_xref="InterPro:IPR001537"
/db_xref="InterPro:IPR013123"
/db_xref="InterPro:IPR029026"
/db_xref="InterPro:IPR029028"
/db_xref="InterPro:IPR029064"
/db_xref="UniProtKB/TrEMBL:P94978"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44409.1"
/translation="MLTERSARVATAVKLHRHVGRRRAGRFLAEGPNLVAAALARGLV
REVFVTEVAARRHELLLAAHEASVHLVTERAAKALSDTVTPAGLVAVCDLPATRLEDV
LAGSPQLIAVTVEIREPGNAGTVIRIADAMGAAAVILAGRSVDPYNGKCLRASTGSIF
AIPVVVAPDVGAAIADLRAAGLQVLATAVDGEMALDDADRLLAEPTAWLFGPEAHGLS
AEIAALADHRVHILMSGGAESLNVAAAAAICLYESARALGRR"
gene complement(1854399..1855454)
/locus_tag="Rv1645c"
CDS complement(1854399..1855454)
/codon_start=1
/transl_table=11
/locus_tag="Rv1645c"
/product="Conserved hypothetical protein"
/note="Rv1645c, (MTCY06H11.10c), len: 351 aa. Conserved
hypothetical protein, similar to other Mycobacterium
tuberculosis hypothetical proteins e.g.
O53837|Rv0826|MTV043.18 (351 aa), FASTA scores: (57.5%
identity in 299 aa overlap); Q10519|Rv2237|YM37_MYCTU (255
aa), O53682|Rv0276 (306 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1645c"
/db_xref="EnsemblGenomes-Tr:CCP44410"
/db_xref="InterPro:IPR018713"
/db_xref="UniProtKB/TrEMBL:P94979"
/protein_id="CCP44410.1"
/translation="MTVASRTSADPLGPDSLTWKYFGDLRTGMMGVWIGAIQNMYPEL
GAGVEEHSILLREPLQRVARSVYPIMGVVYDGDRAAQTGQQIKGYHRTIKGVDAEGRR
YHALNPDTFYWAHATFFMLVIKVAEYFCGGLTEAEKHQLFEEHVRWYRMYGMSMRPVP
KSWEDFQDYWDRVCRDKLEINQATVDILQMRIPKPRFVLMPTPIWDQLFKPLIAGQRW
IAAGLFDPAVREKAGMHWTPGDEVLLRVFGKVVELAFLAVPDEIRLHPRALAAYRRAA
GRTRHDAPLVQAPGFMAPPRDRQGLPMHYFPPRSHRFTRSALDPAKALMERAGALVHS
TLSLAGVRPARGPSRAA"
gene 1855764..1856696
/gene="PE17"
/locus_tag="Rv1646"
CDS 1855764..1856696
/codon_start=1
/transl_table=11
/gene="PE17"
/locus_tag="Rv1646"
/product="PE family protein PE17"
/note="Rv1646, (MTCY06H11.11), len: 310 aa. PE17, Member
of the Mycobacterium tuberculosis PE family of proteins
(see citation below), similar to many e.g.
YW36_MYCTU|Q10873 hypothetical 53.7 kd protein cy39.36c
(558 aa), FASTA scores, opt: 411, E(): 1.3e-15, (34.4%
identity in 320 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1646"
/db_xref="EnsemblGenomes-Tr:CCP44411"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N681"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44411.1"
/translation="MSFLTVAPDMVTAAAGNLESVGSALNEAAAAAAPATVGLAAPAA
DRVSAVVAAMLGAYARDFQGISAQIAGFHNQFVGALRGGAAAYASAEAANVQQTVVNA
VNAPAQALLGHPLIGPETVGSSAAAVSFGFGPLLLAGSDPLLAVPFSYPASLPTPFGP
VTMTLNGSFDPLTQQVVFDSGSLTAPAPFVYGLGAVGPALTTMTALQNSGTAFSGAVQ
SGNLLGAAGALLQAPGNAVTGFLFGQTAISQSIPGPSNLGYESVGISVPVGGLLAPLQ
PVTVTLTPTSGMPTAIQLSGTQFGGLLPALLNGF"
gene 1856774..1857724
/locus_tag="Rv1647"
CDS 1856774..1857724
/codon_start=1
/transl_table=11
/locus_tag="Rv1647"
/product="Adenylate cyclase (ATP pyrophosphate-lyase)
(adenylyl cyclase)"
/note="Rv1647, (MTCY06H11.12), len: 316 aa. Adenylate
cyclase, some similarity to other Mycobacterium
tuberculosis proteins e.g. Q11055|Rv1264|YC64_MYCTU 42.2
kDa protein (397 aa), FASTA scores: opt: 197, E():
9.4e-06,(27.1% identity in 181 aa overlap) and
Q10400|Rv2212|YM12_MYCTU (378 aa). Belongs to adenylyl
cyclase class-3 family."
/db_xref="EnsemblGenomes-Gn:Rv1647"
/db_xref="EnsemblGenomes-Tr:CCP44412"
/db_xref="GOA:P94982"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/TrEMBL:P94982"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44412.1"
/translation="MAGSARTTYPCHVEVGPQDSESGAPDETATAMASPVPRQRSALR
WLRTVNRSPGLVSFIHRARRLLPGDPEFGDPLSTAGEGGPRAAARAADRLLRDRDAAS
REVGLSVLQVWQALTEAVSRRPANPEVTLVFTDLVGFSTWSLHAGDDATLTLLRQVAR
AVESPLLDAGGHIVKRLGDGIMAVFRNPTVALRAVLVAQDAVKSLEVQGYTPRMRIGI
HTGRPQRLAADWLGVDVNIAARVMERATKGGIMISQPTLDLIPQSELDALGVVARRVR
KPVFASKPTGIPPDLAIYRIKTVSESTAADNFDEMSPDAQ"
gene 1857731..1858537
/locus_tag="Rv1648"
CDS 1857731..1858537
/codon_start=1
/transl_table=11
/locus_tag="Rv1648"
/product="Probable transmembrane protein"
/note="Rv1648, (MTCY06H11.13), len: 268 aa. Probable
transmembrane protein, some similarity to
Rv3434c|MTCY77.06C (237 aa), FASTA scores: E():
0.00039,(31.4% identity in 194 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1648"
/db_xref="EnsemblGenomes-Tr:CCP44413"
/db_xref="GOA:P94983"
/db_xref="UniProtKB/TrEMBL:P94983"
/protein_id="CCP44413.1"
/translation="MIYRVACLLARIRFTVGYVAALASVSTTILMHGPQVHAQVIRHA
STNLHNLAHGHLGTLWNSAFVIDEGPLYFWLPCLACLLAVAELQLRSLRLTVAFVVGH
IGATLLVAAVLAGAIEIGWLPWSISRVSDVGMSYGALAALGALTAAIPGRWRPAWIGW
WVSLGLATATIGGGFTDAGHTVALLLGMLVTACFTRPARWTLGRCALLAVASGFCLVL
LAHSWWSLVSGSALGLLGALGAAGFARWTRARATSLPPGALAIPQPALSR"
gene 1858733..1859758
/gene="pheS"
/locus_tag="Rv1649"
CDS 1858733..1859758
/codon_start=1
/transl_table=11
/gene="pheS"
/locus_tag="Rv1649"
/product="Probable phenylalanyl-tRNA synthetase, alpha
chain PheS"
/note="Rv1649, (MTCY06H11.14), len: 341 aa. Probable
pheS,Phenylalanyl-tRNA synthetase alpha chain, similar to
several e.g. SYFA_ECOLI|P08312 from Escherichia coli (327
aa), FASTA scores: opt: 978, E(): 0, (46.5% identity in
331 aa overlap). Homology suggests this start site, but
there is a potential rbs upstream of a gtg 30 bp upstream;
contains PS00179 Aminoacyl-transfer RNA synthetases
class-II signature 1. Belongs to class-II aminoacyl-tRNA
synthetase family. PHE-tRNA synthetase alpha chain
subfamily 1."
/db_xref="EnsemblGenomes-Gn:Rv1649"
/db_xref="EnsemblGenomes-Tr:CCP44414"
/db_xref="GOA:P9WFU3"
/db_xref="InterPro:IPR002319"
/db_xref="InterPro:IPR004188"
/db_xref="InterPro:IPR004529"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR010978"
/db_xref="InterPro:IPR022911"
/db_xref="UniProtKB/Swiss-Prot:P9WFU3"
/inference="protein motif:PROSITE:PS00179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44414.1"
/translation="MLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALA
RQALAVLPKEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLPST
RVPAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNFPADHPARGEQDT
FYIAPEDSRQLLRTHTSPVQIRTLLARELPVYIISIGRTFRTDELDATHTPIFHQVEG
LAVDRGLSMAHLRGTLDAFARAEFGPSARTRIRPHFFPFTEPSAEVDVWFANKIGGAA
WVEWGGCGMVHPNVLRATGIDPDLYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFS
LPFGVGA"
gene 1859758..1862253
/gene="pheT"
/locus_tag="Rv1650"
CDS 1859758..1862253
/codon_start=1
/transl_table=11
/gene="pheT"
/locus_tag="Rv1650"
/product="Probable phenylalanyl-tRNA synthetase, beta
chain PheT"
/note="Rv1650, (MTCY06H11.15), len: 831 aa. Probable
pheT,Phenylalanyl-tRNA synthetase beta chain, similar to
several e.g. SYFB_ECOLI|P07395 from Escherichia coli (795
aa),FASTA scores: opt: 995, E(): 0, (31.8% identity in 847
aa overlap). Belongs to the phenylalanyl-tRNA synthetase
beta chain family - subfamily 1."
/db_xref="EnsemblGenomes-Gn:Rv1650"
/db_xref="EnsemblGenomes-Tr:CCP44415"
/db_xref="GOA:P9WFU1"
/db_xref="InterPro:IPR002547"
/db_xref="InterPro:IPR004532"
/db_xref="InterPro:IPR005121"
/db_xref="InterPro:IPR005146"
/db_xref="InterPro:IPR005147"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR020825"
/db_xref="InterPro:IPR033714"
/db_xref="InterPro:IPR036690"
/db_xref="InterPro:IPR041616"
/db_xref="UniProtKB/Swiss-Prot:P9WFU1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44415.1"
/translation="MRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLG
PVDGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLVVVALPG
ATLPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPPGAAEPGADGAGVLGL
DDVVFHLAITPDRGYCMSVRGLARELACAYDLDFVDPASNSRVPPLPIEGPAWPLTVQ
PETGVRRFALRPVIGIDPAAVSPWWLQRRLLLCGIRATCPAVDVTNYVMLELGHPMHA
HDRNRISGTLGVRFARSGETAVTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEV
RADSTDVLLEAAIWDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLAD
IAGGEVSPTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQIGAVV
THDGDTLTVTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAPAGRGLTAGQQRRR
TIGRSLALSGYVEILPTPFLPAGVFDLWGLEADDSRRMTTRVLNPLEADRPQLATTLL
PALLEALVRNVSRGLVDVALFAIAQVVQPTEQTRGVGLIPVDRRPTDDEIAMLDASLP
RQPQHVAAVLAGLREPRGPWGPGRPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHP
GRCAQVFVGESSVGHAGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYP
AVFQDVSLVVAADIPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFALRF
RAPDRTLTEDDASAARDAAVQSAAERVGAVLRG"
gene complement(1862347..1865382)
/gene="PE_PGRS30"
/locus_tag="Rv1651c"
CDS complement(1862347..1865382)
/codon_start=1
/transl_table=11
/gene="PE_PGRS30"
/locus_tag="Rv1651c"
/product="PE-PGRS family protein PE_PGRS30"
/note="Rv1651c, (MTCY06H11.16c), len: 1011 aa.
PE_PGRS30,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citations
below),similar to many e.g. Q10637|Y03A_MYCTU hypothetical
glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt:
1757, E(): 0, (50.8% identity in 714aa overlap). The
transcription of this CDS seems to be activated in
macrophages (see Ramakrishnan et al., 2000)."
/db_xref="EnsemblGenomes-Gn:Rv1651c"
/db_xref="EnsemblGenomes-Tr:CCP44416"
/db_xref="GOA:Q79FL8"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:Q79FL8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44416.1"
/translation="MSFLLVEPDLVTAAAANLAGIRSALSEAAAAASTPTTALASAGA
DEVSAAVSRLFGAYGQQFQALNARAATFHAEFVSLLNGGAAAYTGAEAASVSSMQALL
DAVNAPTQTLLGRPLIGNGADGVAGTGSNAGGNGGPGGILYGNGGNGGAGGNGGAAGL
IGNGGAGGAGGAGGAGGAGGAGGTGGLLYGNGGAGGNGGSAAAAGGAGGNALLFGNGG
NGGSGASGGAAGHAGTIFGNGGNAGAGSGLAGADGGLFGNGGDGGSSTSKAGGAGGNA
LFGNGGDGGSSTVAAGGAGGNTLVGNGGAGGAGGTSGLTGSGVAGGAGGSVGLWGSGG
AGGDGGAATSLLGVGMNAGAGGAGGNAGLLYGNGGAGGAGGNGGDTTVPLFDSGVGGA
GGAGGNASLFGNGGTGGVGGKGGTSSDLASATSGAGGAGGAGGVGGLLYGNGGNGGAG
GIGGAAINILANAGAGGAGGAAGSSFIGNGGNGGAGGAGGAAALFSSGVGGAGGSGGT
ALLLGSGGAGGNGGTGGANSGSLFASPGGTGGAGGHGGAGGLIWGNGGAGGNGGNGGT
TADGALEGGTGGIGGTGGSAIAFGNGGQGGAGGTGGDHSGGNGIGGKGGASGNGGNAG
QVFGDGGTGGTGGAGGAGSGTKAGGTGSDGGHGGNATLIGNGGDGGAGGAGGAGSPAG
APGNGGTGGTGGVLFGQSGSSGPPGAAALAFPSLSSSVPILGPYEDLIANTVANLASI
GNTWLADPAPFLQQYLANQFGYGQLTLTALTDATRDFAIGLAGIPPSLQSALQALAAG
DVSGAVTDVLGAVVKVFVSGVDASDLSNILLLGPVGDLFPILSIPGAMSQNFTNVVMT
VTDTTIAFSIDTTNLTGVMTFGLPLAMTLNAVGSPITTAIAFAESTTAFVSAVQAGNL
QAAAAALVGAPANVANGFLNGEARLPLALPTSATGGIPVTVEVPVGGILAPLQPFQAT
AVIPVIGPVTVTLEGTPAGGIVPALVNYAPTQLAQAIAP"
gene 1865576..1866634
/gene="argC"
/locus_tag="Rv1652"
CDS 1865576..1866634
/codon_start=1
/transl_table=11
/gene="argC"
/locus_tag="Rv1652"
/product="Probable N-acetyl-gamma-glutamyl-phoshate
reductase ArgC"
/note="Rv1652, (MTCY06H11.17), len: 352 aa. Probable
argC,N-acetyl-gamma-glutamyl-phosphate reductase, similar
to many e.g. ARGC_STRCL|P54896 from Streptomyces
clavuligerus (340 aa), FASTA scores: opt: 1119, E(): 0,
(56.9% identity in 350 aa overlap); etc. Belongs to the
NAGSA dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv1652"
/db_xref="EnsemblGenomes-Tr:CCP44417"
/db_xref="GOA:P9WPZ9"
/db_xref="InterPro:IPR000534"
/db_xref="InterPro:IPR000706"
/db_xref="InterPro:IPR012280"
/db_xref="InterPro:IPR023013"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:2I3A"
/db_xref="PDB:2I3G"
/db_xref="PDB:2NQT"
/db_xref="UniProtKB/Swiss-Prot:P9WPZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44417.1"
/translation="MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGA
LTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSP
ETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYP
TAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHR
HTPEIAQGLRAVTDRDVSVSFTPVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAE
PFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMN
LALGWPETDGLSVVGVAP"
gene 1866631..1867845
/gene="argJ"
/locus_tag="Rv1653"
CDS 1866631..1867845
/codon_start=1
/transl_table=11
/gene="argJ"
/locus_tag="Rv1653"
/product="Probable glutamate N-acetyltransferase ArgJ"
/note="Rv1653, (MTCY06H11.18), len: 404 aa. Probable
argJ,Glutamate n-acetyltransferase, similar to
ARGJ_BACSU|P36843 from Bacillus subtilis (406 aa), fasta
scores: opt: 727,E(): 0, (36.3% identity in 410 a a
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1653"
/db_xref="EnsemblGenomes-Tr:CCP44418"
/db_xref="GOA:P9WPZ3"
/db_xref="InterPro:IPR002813"
/db_xref="InterPro:IPR016117"
/db_xref="InterPro:IPR042195"
/db_xref="PDB:3IT4"
/db_xref="PDB:3IT6"
/db_xref="UniProtKB/Swiss-Prot:P9WPZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44418.1"
/translation="MTDLAGTTRLLRAQGVTAPAGFRAAGVAAGIKASGALDLALVFN
EGPDYAAAGVFTRNQVKAAPVLWTQQVLTTGRLRAVILNSGGANACTGPAGFADTHAT
AEAVAAALSDWGTETGAIEVAVCSTGLIGDRLPMDKLLAGVAHVVHEMHGGLVGGDEA
AHAIMTTDNVPKQVALHHHDNWTVGGMAKGAGMLAPSLATMLCVLTTDAAAEPAALER
ALRRAAAATFDRLDIDGSCSTNDTVLLLSSGASEIPPAQADLDEAVLRVCDDLCAQLQ
ADAEGVTKRVTVTVTGAATEDDALVAARQIARDSLVKTALFGSDPNWGRVLAAVGMAP
ITLDPDRISVSFNGAAVCVHGVGAPGAREVDLSDADIDITVDLGVGDGQARIRTTDLS
HAYVEENSAYSS"
gene 1867842..1868726
/gene="argB"
/locus_tag="Rv1654"
CDS 1867842..1868726
/codon_start=1
/transl_table=11
/gene="argB"
/locus_tag="Rv1654"
/product="Probable acetylglutamate kinase ArgB"
/note="Rv1654, (MTCY06H11.19), len: 294 aa. Probable
argB,Acetylglutamate kinase, similar to ARGB_CORGL|Q59281
(294 aa), FASTA scores: opt: 1209, E(): 0, (64.4% identity
in 270 aa overlap). Belongs to the acetylglutamate kinase
family."
/db_xref="EnsemblGenomes-Gn:Rv1654"
/db_xref="EnsemblGenomes-Tr:CCP44419"
/db_xref="GOA:P9WQ01"
/db_xref="InterPro:IPR001048"
/db_xref="InterPro:IPR001057"
/db_xref="InterPro:IPR004662"
/db_xref="InterPro:IPR036393"
/db_xref="InterPro:IPR037528"
/db_xref="InterPro:IPR041727"
/db_xref="PDB:2AP9"
/db_xref="UniProtKB/Swiss-Prot:P9WQ01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44419.1"
/translation="MSRIEALPTHIKAQVLAEALPWLKQLHGKVVVVKYGGNAMTDDT
LRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEGDFKGGFRVTTPEVLDVAR
MVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVRRSVTVDGVATDIGLVGDVDQV
NTAAMLDLVAAGRIPVVSTLAPDADGVVHNINADTAAAAVAEALGAEKLLMLTDIDGL
YTRWPDRDSLVSEIDTGTLAQLLPTLESGMVPKVEACLRAVIGGVPSAHIIDGRVTHC
VLVELFTDAGTGTKVVRG"
gene 1868723..1869925
/gene="argD"
/locus_tag="Rv1655"
CDS 1868723..1869925
/codon_start=1
/transl_table=11
/gene="argD"
/locus_tag="Rv1655"
/product="Probable acetylornithine aminotransferase ArgD"
/note="Rv1655, (MTCY06H11.20), len: 400 aa. Probable
argD,Acetylornithine aminotransferase, similar to
ARGD_ECOLI|P18335 (406 aa), FASTA scores: opt: 958, E():
0,(38.6% identity in 404 aa overlap), contains PS00600
Aminotransferases class-III pyridoxal-phosphate attachment
site. Belongs to class-III of
pyridoxal-phosphate-dependent aminotransferases."
/db_xref="EnsemblGenomes-Gn:Rv1655"
/db_xref="EnsemblGenomes-Tr:CCP44420"
/db_xref="GOA:P9WPZ7"
/db_xref="InterPro:IPR004636"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WPZ7"
/inference="protein motif:PROSITE:PS00600"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44420.1"
/translation="MTGASTTTATMRQRWQAVMMNNYGTPPIALASGDGAVVTDVDGR
TYIDLLGGIAVNVLGHRHPAVIEAVTRQMSTLGHTSNLYATEPGIALAEELVALLGAD
QRTRVFFCNSGAEANEAAFKLSRLTGRTKLVAAHDAFHGRTMGSLALTGQPAKQTPFA
PLPGDVTHVGYGDVDALAAAVDDHTAAVFLEPIMGESGVVVPPAGYLAAARDITARRG
ALLVLDEVQTGMGRTGAFFAHQHDGITPDVVTLAKGLGGGLPIGACLAVGPAAELLTP
GLHGSTFGGNPVCAAAALAVLRVLASDGLVRRAEVLGKSLRHGIEALGHPLIDHVRGR
GLLLGIALTAPHAKDAEATARDAGYLVNAAAPDVIRLAPPLIIAEAQLDGFVAALPAI
LDRAVGAP"
gene 1869922..1870845
/gene="argF"
/gene_synonym="OTC"
/locus_tag="Rv1656"
CDS 1869922..1870845
/codon_start=1
/transl_table=11
/gene="argF"
/gene_synonym="OTC"
/locus_tag="Rv1656"
/product="Probable ornithine carbamoyltransferase,
anabolic ArgF"
/note="Rv1656, (MTCY06H11.21), len: 307 aa. Probable
argF,ornithine carbamoyltransferase, anabolic (see
citation below), almost identical to OTCA_MYCBO|Q02095
ornithine carbamoyltransferase, anabolic from
Mycobacterium bovis (307 aa), FASTA scores: opt: 1980,
E(): 0, (99.0% identity in 307 aa overlap); contains
PS00097 Aspartate and ornithine carbamoyltransferases
signature. Belongs to the ATCases/OTCases family."
/db_xref="EnsemblGenomes-Gn:Rv1656"
/db_xref="EnsemblGenomes-Tr:CCP44421"
/db_xref="GOA:P9WIT9"
/db_xref="InterPro:IPR002292"
/db_xref="InterPro:IPR006130"
/db_xref="InterPro:IPR006131"
/db_xref="InterPro:IPR006132"
/db_xref="InterPro:IPR024904"
/db_xref="InterPro:IPR036901"
/db_xref="PDB:2I6U"
/db_xref="PDB:2P2G"
/db_xref="UniProtKB/Swiss-Prot:P9WIT9"
/inference="protein motif:PROSITE:PS00097"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44421.1"
/translation="MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAV
IFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRT
FGQERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANN
MAHSLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGA
DVLVTDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDA
VMDGPASAVWDEAENRLHAQKALLVWLLERS"
gene 1870842..1871354
/gene="argR"
/gene_synonym="ahrC"
/locus_tag="Rv1657"
CDS 1870842..1871354
/codon_start=1
/transl_table=11
/gene="argR"
/gene_synonym="ahrC"
/locus_tag="Rv1657"
/product="Probable arginine repressor ArgR (AHRC)"
/note="Rv1657, (MTCY06H11.22), len: 170 aa. Probable
argR,Arginine repressor (alternate gene name: ahrC).
Similar to AHRC_BACSU|P17893 arginine hydroximate
resistance protein from Bacillus subtilis (149 aa), FASTA
scores: opt: 283,E(): 1.8e-11, (34.5% identity in 142 aa
overlap); and ARGR_ECOLI|P15282 arginine repressor from
Escherichia coli (156 aa), FASTA scores: opt: 194, E():
6.4e-06, (30.8% identity in 146 aa overlap). Belongs to
the ArgR family."
/db_xref="EnsemblGenomes-Gn:Rv1657"
/db_xref="EnsemblGenomes-Tr:CCP44422"
/db_xref="GOA:P9WPY9"
/db_xref="InterPro:IPR001669"
/db_xref="InterPro:IPR020899"
/db_xref="InterPro:IPR020900"
/db_xref="InterPro:IPR036251"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:2ZFZ"
/db_xref="PDB:3BUE"
/db_xref="PDB:3CAG"
/db_xref="PDB:3ERE"
/db_xref="PDB:3FHZ"
/db_xref="PDB:3LAJ"
/db_xref="PDB:3LAP"
/db_xref="UniProtKB/Swiss-Prot:P9WPY9"
/protein_id="CCP44422.1"
/translation="MSRAKAAPVAGPEVAANRAGRQARIVAILSSAQVRSQNELAALL
AAEGIEVTQATLSRDLEELGAVKLRGADGGTGIYVVPEDGSPVRGVSGGTDRMARLLG
ELLVSTDDSGNLAVLRTPPGAAHYLASAIDRAALPQVVGTIAGDDTILVVAREPTTGA
QLAGMFENLR"
gene 1871363..1872559
/gene="argG"
/locus_tag="Rv1658"
CDS 1871363..1872559
/codon_start=1
/transl_table=11
/gene="argG"
/locus_tag="Rv1658"
/product="Probable argininosuccinate synthase ArgG"
/note="Rv1658, (MTCY06H11.23), len: 398 aa. Probable
argG,Argininosuccinate synthase, similar to
ASSY_STRCL|P50986 argininosuccinate synthase from
Streptomyces clavuligerus (397 aa), FASTA scores: opt:
1873, E(): 0, (67.8% identity in 397 aa overlap); contains
PS00564 Argininosuccinate synthase signature 1, PS00565
Argininosuccinate synthase signature 2. Belongs to the
argininosuccinate synthase family."
/db_xref="EnsemblGenomes-Gn:Rv1658"
/db_xref="EnsemblGenomes-Tr:CCP44423"
/db_xref="GOA:P9WPW7"
/db_xref="InterPro:IPR001518"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR018223"
/db_xref="InterPro:IPR023434"
/db_xref="InterPro:IPR024074"
/db_xref="UniProtKB/Swiss-Prot:P9WPW7"
/inference="protein motif:PROSITE:PS00564"
/inference="protein motif:PROSITE:PS00565"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44423.1"
/translation="MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEHM
DVIRQRALDCGAVEAVVVDARDEFAEGYCLPTVLNNALYMDRYPLVSAISRPLIVKHL
VAAAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAE
ENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDIYAYTEDPTINWGVPDEV
IVGFERGVPVSVDGKPVSMLAAIEELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPG
AMVLITAHTELEHVTLERELGRFKRQTDQRWAELVYDGLWYSPLKAALEAFVAKTQEH
VSGEVRLVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAARGFVYVHGLSSKLA
ARRDLR"
gene 1872639..1874051
/gene="argH"
/locus_tag="Rv1659"
CDS 1872639..1874051
/codon_start=1
/transl_table=11
/gene="argH"
/locus_tag="Rv1659"
/product="Probable argininosuccinate lyase ArgH"
/note="Rv1659, (MTCY06H11.24), len: 470 aa. Probable
argH,Argininosuccinate lyase, similar to ARLY_ECOLI|P11447
argininosuccinate lyase from Escherichia coli (457
aa),FASTA scores: opt: 1091, E(): 0, (42.5% identity in
461 aa overlap); contains PS00017 ATP/GTP-binding site
motif A,PS00163 Fumarate lyases signature. Belongs to the
lyase 1 family. Argininosuccinate lyase subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1659"
/db_xref="EnsemblGenomes-Tr:CCP44424"
/db_xref="GOA:P9WPY7"
/db_xref="InterPro:IPR000362"
/db_xref="InterPro:IPR008948"
/db_xref="InterPro:IPR009049"
/db_xref="InterPro:IPR020557"
/db_xref="InterPro:IPR022761"
/db_xref="InterPro:IPR024083"
/db_xref="InterPro:IPR029419"
/db_xref="PDB:6IEM"
/db_xref="PDB:6IEN"
/db_xref="PDB:6IG5"
/db_xref="PDB:6IGA"
/db_xref="UniProtKB/Swiss-Prot:P9WPY7"
/inference="protein motif:PROSITE:PS00163"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44424.1"
/translation="MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRA
HTMVLFRAGLLTEEQRDGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRVGP
DLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAAHPSAIMPGKT
HLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIA
ADLGFSAAADNSVDATAARDFAAEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHD
SWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVF
DSVAQLELLLPAMAGLVASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEA
AGAAVRAAEQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRV
AEQLNAIGEAAERLRRQLVR"
gene 1874160..1875221
/gene="pks10"
/locus_tag="Rv1660"
CDS 1874160..1875221
/codon_start=1
/transl_table=11
/gene="pks10"
/locus_tag="Rv1660"
/product="Chalcone synthase Pks10"
/note="Rv1660, (MTCY06H11.25), len: 353 aa. pks10,
chalcone synthase, similar to BCSA_BACSU|P54157 putative
chalcone synthase from B. subtilis (365 aa), FASTA scores:
opt: 701,E(): 0, (33.1% identity in 362 aa overlap). Also
similar to M. tuberculosis Rv1665|pks11 polyketide
synthase (chalcone synthase); and Rv1372|pks18 polyketide
synthase. Other upstream initiation sites are possible but
homology suggests this start. Note pks10 has been shown to
be involved in the biosynthesis of phthiocerol."
/db_xref="EnsemblGenomes-Gn:Rv1660"
/db_xref="EnsemblGenomes-Tr:CCP44425"
/db_xref="GOA:P9WPF5"
/db_xref="InterPro:IPR001099"
/db_xref="InterPro:IPR011141"
/db_xref="InterPro:IPR012328"
/db_xref="InterPro:IPR016039"
/db_xref="UniProtKB/Swiss-Prot:P9WPF5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44425.1"
/translation="MSVIAGVFGALPPYRYSQRELTDSFVSIPDFEGYEDIVRQLHAS
AKVNSRHLVLPLEKYPKLTDFGEANKIFIEKAVDLGVQALAGALDESGLRPEDLDVLI
TATVTGLAVPSLDARIAGRLGLRADVRRVPLFGLGCVAGAAGVARLHDYLRGAPDGVA
ALVSVELCSLTYPGYKPTLPGLVGSALFADGAAAVVAAGVKRAQDIGADGPDILDSRS
HLYPDSLRTMGYDVGSAGFELVLSRDLAAVVEQYLGNDVTTFLASHGLSTTDVGAWVT
HPGGPKIINAITETLDLSPQALELTWRSLGEIGNLSSASVLHVLRDTIAKPPPSGSPG
LMIAMGPGFCSELVLLRWH"
gene 1875304..1881684
/gene="pks7"
/locus_tag="Rv1661"
CDS 1875304..1881684
/codon_start=1
/transl_table=11
/gene="pks7"
/locus_tag="Rv1661"
/product="Probable polyketide synthase Pks7"
/note="Rv1661, (MTCY06H11.26), len: 2126 aa. Probable
pks7,polyketide synthase, similar to many e.g.
ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4
(3567 aa), FASTA scores: E(): 0, (48.8% identity in 2131
aa overlap); also similar to Mycobacterium tuberculosis
pks12. Contains PS00606 Beta-ketoacyl synthases active
site, PS00012 Phosphopantetheine attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1661"
/db_xref="EnsemblGenomes-Tr:CCP44426"
/db_xref="GOA:P94996"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR041314"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/TrEMBL:P94996"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00013"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44426.1"
/translation="MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGC
RYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTD
VAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHG
SYGGQGRVPGDLERYGLRGSTLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQ
SLRLGECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVL
VLARLADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVAD
VDVVEGHGTGTTLGDPIEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIK
MVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGT
NAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPL
DVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVF
PGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDV
VQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRL
LVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRC
EAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGV
NAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEP
IVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWL
DGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVV
LFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWV
YSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYG
YGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTML
PFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALS
RSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLE
VLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD
GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGT
LADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVG
PGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSV
LAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISD
SRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTV
AERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFV
SQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVS
RSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGV
LDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNY
AAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTE
QALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVS
MSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVE
LRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELV
VLLDQPDLSANVKAHLRTRLQTMLTSLTTEDDDIAAATESQLFAILDEELGS"
gene 1881704..1886512
/gene="pks8"
/locus_tag="Rv1662"
CDS 1881704..1886512
/codon_start=1
/transl_table=11
/gene="pks8"
/locus_tag="Rv1662"
/product="Probable polyketide synthase Pks8"
/note="Rv1662, (MTCY275.01-MTCY06H11.27), len: 1602 aa.
Probable pks8, polyketide synthase, similar to many
polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide
synthase, modules 3 and 4 from Saccharopolyspora erythraea
(Streptomyces erythraeus) (3567 aa), FASTA scores: opt:
3319, E(): 0, (45.8% identity in 1619 aa overlap). Also
similar to other Mycobacterium tuberculosis probable
polyketide synthases e.g. pks7 and pks12. Contains PS00606
Beta-ketoacyl synthases active site and PS01162 Quinone
oxidoreductase/zeta-crystallin signature. Note that the
similarity extends into the downstream ORF Rv1663
(MTCY275.02), and this could be accounted for by a
frameshift, although the sequence has been checked and no
discrepancy was found."
/db_xref="EnsemblGenomes-Gn:Rv1662"
/db_xref="EnsemblGenomes-Tr:CCP44427"
/db_xref="GOA:O65933"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR002364"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR015083"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/TrEMBL:O65933"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS01162"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44427.1"
/translation="MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCR
YPGGVDSPETLWELVAQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHA
GDFDAGFFGIGPSEALAMDPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAG
YGGQLSGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLR
SGECDLALAGGVTVMATPAAFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVE
RLVDARRLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVDV
VEGHGTGTMLGDPIEAQALLATYGQDRVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQA
MRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHV
ILEQAPVVESVVPEVASPTAASAVPWVLSARSEQALAGQAQRLLAFVAANPDLDPIDV
GWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESGAGVAVGRARSVGKTVFVFPG
QGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQP
ALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAE
LPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRR
VHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWV
EHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPE
VSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGV
GLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALR
AADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVL
HARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRE
SELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAG
ASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGL
LEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGRLV
VLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI
RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRI
EVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGS
EAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGM
AAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDV
VLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST"
gene 1886512..1888020
/gene="pks17"
/locus_tag="Rv1663"
CDS 1886512..1888020
/codon_start=1
/transl_table=11
/gene="pks17"
/locus_tag="Rv1663"
/product="Probable polyketide synthase Pks17"
/note="Rv1663, (MTCY275.02), len: 502 aa. Probable
pks17,polyketide synthase, similar to other polyketide
synthases e g. ERY2_SACER|Q03132 erythronolide synthase,
modules 3 and 4 (3567 aa) from Saccharopolyspora erythraea
(Streptomyces erythraeus), FASTA scores: opt: 1207, E():
0,(43.9% identity in 531 aa overlap). Also similar to
other Mycobacterium tuberculosis probable polyketide
synthases e.g. pks7 and pks1. Note that the similarity
extends into the upstream ORF Rv1662 (MTCY275.01) and this
could be accounted for by a frameshift, although the
sequence has been checked and no discrepancy was found.
Contains PS00012 Phosphopantetheine attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1663"
/db_xref="EnsemblGenomes-Tr:CCP44428"
/db_xref="GOA:O06585"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/TrEMBL:O06585"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44428.1"
/translation="MEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFL
SQARHVGKVVLTMPDAWAAGTVLITGGTGMAGSAVARHLVSRYGVRQVVLASRAGEHT
ESVAALVDELGSAGARVQVVSCDVADRDAVAGLVASQPDLTAVFHAAGVLDDAVITGL
TPERVDKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDG
LAAYRRSRGLAALSVAWGLWEQASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAA
LLADRPVVVAARLDRAALAGAELPALFSQLVAGPIRRIIDGADEVSGSGLASRLHGLT
PEQRHRELTELVCSNAAIVLGHSGTEIDAHKAFQDLGFDSLTAVELRNRLKTATGLTL
PPTLIFDYPTAAELAEHLDIQLANAPAVTVDQPNPSTRFNEVTRELQALLDQPNWNPD
DKTRLIKRLQAILTDCTAPPASSGPSTTHDDEDITTATESQLFAILDDELGP"
gene 1888026..1891079
/gene="pks9"
/locus_tag="Rv1664"
CDS 1888026..1891079
/codon_start=1
/transl_table=11
/gene="pks9"
/locus_tag="Rv1664"
/product="Probable polyketide synthase Pks9"
/note="Rv1664, (MTCY275.03), len: 1017 aa. Probable
pks9,polyketide synthase, similar to OL56_STRAT|Q07017
oleandomycin polyketide synthase, modules 5 and 6 from
Streptomyces antibioticus (3519 aa), FASTA scores: opt:
1767, E(): 0, (41.6% identity in 919 aa overlap). Similar
to other Mycobacterium tuberculosis probable polyketide
synthases e.g. pks6, pks8, etc. Contains PS00012
Phosphopantetheine attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1664"
/db_xref="EnsemblGenomes-Tr:CCP44429"
/db_xref="GOA:O06586"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/TrEMBL:O06586"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44429.1"
/translation="MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADF
DADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAV
LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRT
GEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKP
VQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHY
VEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLA
IENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVIL
EQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALD
VGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFP
GQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQ
PALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQ
ALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGR
RVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYW
VEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRL
FAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQS
LAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG
LPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLL
DKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR"
gene 1891226..1892287
/gene="pks11"
/locus_tag="Rv1665"
CDS 1891226..1892287
/codon_start=1
/transl_table=11
/gene="pks11"
/locus_tag="Rv1665"
/product="Chalcone synthase Pks11"
/note="Rv1665, (MTCY275.04-MTV047.01), len: 353 aa.
pks11,chalcone synthase, some similarity to
BCSA_BACSU|P54157 putative chalcone synthase from Bacillus
subtilis (365 aa),FASTA scores: opt: 615, E(): 6.2e-32,
(33.4% identity in 308 aa overlap); and to many plant
chalcone synthases e.g. CHS_VIGUN|P51089 chalcone synthase
(388 aa), FASTA scores: opt: 391, E(): 7.8e-18, (27.2%
identity in 349 aa overlap). Highly similar to upstream
ORF Rv1660|MTCY06H11.25 pks10 (72.7% identity in 308 aa
overlap); and Rv1372 pks18."
/db_xref="EnsemblGenomes-Gn:Rv1665"
/db_xref="EnsemblGenomes-Tr:CCP44430"
/db_xref="GOA:P9WPF3"
/db_xref="InterPro:IPR001099"
/db_xref="InterPro:IPR011141"
/db_xref="InterPro:IPR012328"
/db_xref="InterPro:IPR016039"
/db_xref="PDB:4JAO"
/db_xref="PDB:4JAP"
/db_xref="PDB:4JAQ"
/db_xref="PDB:4JAR"
/db_xref="PDB:4JAT"
/db_xref="PDB:4JD3"
/db_xref="UniProtKB/Swiss-Prot:P9WPF3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44430.1"
/translation="MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAA
AKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIA
TATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVA
VLVSVELCSLTYPAVKPTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRS
SLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVS
HPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEKRPPSGSAG
LMLAMGPGFCTELVLLRWR"
gene complement(1892270..1893562)
/gene="cyp139"
/locus_tag="Rv1666c"
CDS complement(1892270..1893562)
/codon_start=1
/transl_table=11
/gene="cyp139"
/locus_tag="Rv1666c"
/product="Probable cytochrome P450 139 Cyp139"
/note="Rv1666c, (MT1706, MTV047.02c), len: 430 aa.
Probable cyp139, cytochrome P450, similar to many e.g.
U38537|APU38537_7 from Anabaena sp. (459 aa), FASTA
scores: opt: 516, E(): 1.7e-26, (25.8% identity in 418 aa
overlap). Contains PS00086 Cytochrome P450 cysteine
heme-iron ligand signature. Belongs to the cytochrome P450
family."
/db_xref="EnsemblGenomes-Gn:Rv1666c"
/db_xref="EnsemblGenomes-Tr:CCP44431"
/db_xref="GOA:P9WPM1"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002403"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPM1"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP44431.1"
/translation="MRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFAN
ADAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNID
TVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQ
VMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTT
LSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAAD
DLSALTYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPE
IWPEPTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR
AMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ"
gene complement(1893577..1894230)
/locus_tag="Rv1667c"
CDS complement(1893577..1894230)
/codon_start=1
/transl_table=11
/locus_tag="Rv1667c"
/product="Probable second part of macrolide-transport
ATP-binding protein ABC transporter"
/note="Rv1667c, (MTV047.03c), len: 217 aa. Probable second
part of macrolide-transport ATP-binding protein ABC
transporter (see citation below), with similarity to
C-terminal end of putative ABC transporters/ATP binding
proteins, e.g. Z99108|BSUB0005_6 ABC transporter
(ATP-binding protein) homolog yfmR from Bacillus subtilis
(629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8%
identity in 217 aa overlap); etc. Similarity to other NBD
components of ABC transporters suggests that Rv1667c and
Rv1668c should be contiguous. However, sequence has been
checked and no errors found, also same sequence in M.
tuberculosis CSU93 and Mycobacterium bovis."
/db_xref="EnsemblGenomes-Gn:Rv1667c"
/db_xref="EnsemblGenomes-Tr:CCP44432"
/db_xref="GOA:O53915"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O53915"
/protein_id="CCP44432.1"
/translation="MLGRLRGGYQVEGREVTPTQLLERLGFRRDQLSARVDDLSGGQR
RRLQLMLTLLSEPNVLLLDEPTNDVDTEMLTATEDLLDSWAGTLIVVSHDRYLLERVT
DQQYAILDDRLRHLPGGIDEYLQLAARVSAPAPAERPAPPAMSGAQRRATEKELAAVD
RQLARLADRVAAKHTELAEHDQSDHVGITRLTQQLRVLQDHVAAMENRWLELSEMLE"
gene complement(1894224..1895342)
/locus_tag="Rv1668c"
CDS complement(1894224..1895342)
/codon_start=1
/transl_table=11
/locus_tag="Rv1668c"
/product="Probable first part of macrolide-transport
ATP-binding protein ABC transporter"
/note="Rv1668c, (MTV047.04c), len: 372 aa. Probable first
part of macrolide-transport ATP-binding protein ABC
transporter (see citation below), similar to many
ATP-binding proteins ABC transporter e.g.
X80735|SEABCT_1|Q54072 Saccharopolyspora erythraea ertX
gene (481 aa), FASTA scores: opt: 938, E(): 0, (45.6%
identity in 353 aa overlap); etc. Similarity to other NBD
components of ABC transporters suggests that Rv1667c and
Rv1668c should be contiguous. However, sequence has been
checked and no error found, also same sequence in
Mycobacterium tuberculosis CSU93 and Mycobacterium bovis.
Contains PS00211 ABC transporters family signature and two
times PS00017 ATP/GTP-binding site motif A. Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1668c"
/db_xref="EnsemblGenomes-Tr:CCP44433"
/db_xref="GOA:O53916"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR032781"
/db_xref="UniProtKB/TrEMBL:O53916"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/protein_id="CCP44433.1"
/translation="MAHLLGAEAVHLAYPTQVVFEAVTLGVNDGARIGIVGRNGDGKS
SLLGLLTGQLRPDSGRVTRRSGLRVNALSQTDTLDPNRTVGWTLIGDQPEHQWAGNPR
IRDVVAGLVSDIAWDTPVSTLSGGQRRRVQLASLLVGEWDVIALDEPTNHLDIQGITW
LADHLRRRWARNTGGLLVVTHDRWFLDEVATTTWEVHDGIVEPFEGGYAAYVLQRVER
DRLTAAAEAKRQNLLRKELAWLRRGAPARTCKPKFRIEAANQLIADVPPPRNTVELAK
LAAARLGKDVVDLLGVSVSYQPSGGRPVLRDIEWRIGPGERIGIVGANGAGKSTLLGL
IAGTVQPGVGRVKPSGWQCSISTGTIWHRLPTTGSPMC"
gene 1895725..1896087
/locus_tag="Rv1669"
CDS 1895725..1896087
/codon_start=1
/transl_table=11
/locus_tag="Rv1669"
/product="Hypothetical protein"
/note="Rv1669, (MTV047.04B), len: 120 aa. Hypothetical
unknown protein. Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1669"
/db_xref="EnsemblGenomes-Tr:CCP44434"
/db_xref="UniProtKB/TrEMBL:O86371"
/protein_id="CCP44434.1"
/translation="MSRRPGYSNGRAGASRQAARGGSAGASSVAFSSQPNCGLTESVL
GHQVTGICLGTIHLDAMQWPWSSAYRLEPAVATTLIGISAWWANGSVKQYAGDLTDRV
ATMTVCRRTPAPRVHYRQ"
gene 1896120..1896467
/locus_tag="Rv1670"
CDS 1896120..1896467
/codon_start=1
/transl_table=11
/locus_tag="Rv1670"
/product="Conserved hypothetical protein"
/note="Rv1670, (MTV047.05), len: 115 aa. Conserved
hypothetical protein, highly similar to D90908|D90908_87
Hypothetical protein of Synechocystis sp. PCC6803 complete
(94 aa), FASTA scores opt: 378, E(): 3.5e-2, (55.2%
identity in 96 aa overlap); also shows some similarity to
Mycobacterium tuberculosis hypothetical proteins e.g.
C-terminal region of O53404|Rv1056 (254 aa), and
P96817|Rv0140 (126 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1670"
/db_xref="EnsemblGenomes-Tr:CCP44435"
/db_xref="InterPro:IPR007361"
/db_xref="InterPro:IPR038694"
/db_xref="UniProtKB/TrEMBL:O53917"
/protein_id="CCP44435.1"
/translation="MIRAVWNGTVLAEAPRTVRVEGNHYFPPESLHREHLIESPTTSI
CPWKGLAHYYNVVVDGPYGPVNPDAAWYYRRPSPLARRIKNHVAFWHGVTVEGESESR
HGLARRVVAWLGK"
gene 1896475..1896867
/locus_tag="Rv1671"
CDS 1896475..1896867
/codon_start=1
/transl_table=11
/locus_tag="Rv1671"
/product="Probable membrane protein"
/note="Rv1671, (MTV047.06), len: 130 aa. Probable membrane
protein. Weak similarity to mercuric transport proteins."
/db_xref="EnsemblGenomes-Gn:Rv1671"
/db_xref="EnsemblGenomes-Tr:CCP44436"
/db_xref="GOA:O53918"
/db_xref="UniProtKB/TrEMBL:O53918"
/protein_id="CCP44436.1"
/translation="MPTVGPADHAAGLDRRATPDQLPIWRIGIISGLVGMLCCVGPTI
LALVGIISAATAFAWANDLYDNYAWWFRVSGLAVLAILVWWALRHRNRCSVNAIRRLR
WRLMAVLAIAVGTYGVLSAVTTWFGTFV"
gene complement(1896876..1898207)
/locus_tag="Rv1672c"
CDS complement(1896876..1898207)
/codon_start=1
/transl_table=11
/locus_tag="Rv1672c"
/product="Probable conserved integral membrane transport
protein"
/note="Rv1672c, (MTV047.07c), len: 443 aa. Probable
conserved integral membrane transport protein, major
facilitator superfamily, similar to several phthalate
transporters or tartrate transporters e.g.
U25634|AVU25634_2 Agrobacterium vitis plasmid pTrAB (433
aa), FASTA scores: opt: 914, E(): 0, (37.1% identity in
426 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1672c"
/db_xref="EnsemblGenomes-Tr:CCP44437"
/db_xref="GOA:O53919"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O53919"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44437.1"
/translation="MATIAASPTHNALGKAARRLLPLLFVLYVINFVDRANISVAALA
MNADLRLSATAYGTAAGVFFLGYVLFQVPANAALARFGAGRTLTAVVLAWGVCSAATA
LVTSAHTLYLARFALGVAEGGFFPGVIAYLTVWFPCAQRARAVATFLLAIPVANTVGL
PLSGLIVGHVHMAGLPGWRAMFVIEALPALLLAPLLRRLLPDNPQRASWLTPEERAEL
SARLTEDTPAPTGRSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVASLAHGTATLT
AATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTAAGSAALGAALSPMSPIVT
LSWLTIAVAGILAAMPAFWSRCTAALAGPRVAVAIATVNAVASLASFAGPYATGHLKD
ATGTYHLALLTVAAVLAAAAACSLLLRHAGRTVCANDSEIMLHPSPATPFV"
gene complement(1898300..1899232)
/locus_tag="Rv1673c"
CDS complement(1898300..1899232)
/codon_start=1
/transl_table=11
/locus_tag="Rv1673c"
/product="Conserved hypothetical protein"
/note="Rv1673c, (MTV047.08c), len: 310 aa. Conserved
hypothetical protein, shows weak similarity to
P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor
(369 aa), FASTA scores: E(): 8.3e-11, (26.1% identity in
330 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1673c"
/db_xref="EnsemblGenomes-Tr:CCP44438"
/db_xref="InterPro:IPR002931"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/TrEMBL:O53920"
/protein_id="CCP44438.1"
/translation="MTITDPAVSAHADATIGLFEITDHITIDSTQGAHTVEMWCPVIG
DGAFQRVLDVEVTSEDPYDLTREPEFGNLMLYSRLRLATAASWSIRYVVERRAIGHAP
DPARARPLATAQLFSRALIPEAHVDVDERTRTLAQDVVGPETNPLEQARRIYDYVTGA
MDYDATKQSFLGSTEHALTCSVGNCNDIHALFVSLCRSVDIPARFVLGQALELPQPGA
QDCEVCGYHCWAEFFVAGLGWLPADASCATKYGTHGLFANLQANHIAWSIGRDILLAP
PQRAGRSLFFAGPYAEIDGETHPAQRQIRFTAMT"
gene complement(1899260..1899916)
/locus_tag="Rv1674c"
CDS complement(1899260..1899916)
/codon_start=1
/transl_table=11
/locus_tag="Rv1674c"
/product="Probable transcriptional regulatory protein"
/note="Rv1674c, (MTV047.09c), len: 218 aa. Probable
transcriptional regulatory protein. Highly similar to
AJ005575|SPE005575_2 Streptomyces peucetius (226 aa),
FASTA scores: opt: 662, E(): 0, (50.0% identity in 208 aa
overlap). Similar to Rv0324|Z96800|MTCY63.29 M.
tuberculosis cosmid (226 aa), FASTA scores: opt: 579, E():
0, (45.3% identity in 214 aa overlap). N-terminus is
similar to transcriptional activators e.g.
MERR_STRLI|P30346 probable mercury resistance operon
regulator (125 aa), FASTA scores: opt: 183, E():
1.9e-06,(35.6% identity in 90 aa overlap). Contains
PS00380 Rhodanese signature 1."
/db_xref="EnsemblGenomes-Gn:Rv1674c"
/db_xref="EnsemblGenomes-Tr:CCP44439"
/db_xref="GOA:O53921"
/db_xref="InterPro:IPR001307"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR036873"
/db_xref="UniProtKB/TrEMBL:O53921"
/inference="protein motif:PROSITE:PS00380"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44439.1"
/translation="MSGAKKLIFEQFALVGQALSSGHRLELLDLLVQGERSVDALARA
SGLTFANASQHLLQLRRAGLVTSRRDGKRVIYALSDPQVWDVVRAVRAVAERNLASVG
SLVRQYYTDRDSLEPISRDELQARVAAGSVLVLDVRPAMEYAAGHLPGAVSIPLDELA
ERLDELPSGIDIVACCRGPYCVYAYDALELLRPNGFSARRLDGGFSEWLAADLPVVRT
"
gene complement(1900241..1900975)
/gene="cmr"
/locus_tag="Rv1675c"
CDS complement(1900241..1900975)
/codon_start=1
/transl_table=11
/gene="cmr"
/locus_tag="Rv1675c"
/product="Probable transcriptional regulatory protein Cmr"
/note="Rv1675c, (MTV047.10c), len: 244 aa. Probable
cmr,cAMP and macrophage regulator, transcriptional
regulatory protein, weak similarity to D00496|LBATRP_7 trp
operon from Lactobacillus casei (219 aa), FASTA scores:
opt: 172, E(): 0.00011, (26.9% identity in 186 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1675c"
/db_xref="EnsemblGenomes-Tr:CCP44440"
/db_xref="GOA:P9WMH5"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR012318"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44440.1"
/translation="MADRSVRPLRHLVHAVTGGQPPSEAQVRQAAWIARCVGRGGSAP
LHRDDVSALAETLQVKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNIL
HPGDVDGDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSVAQR
VSTAQIRLMGMLGRPLPAQVAQLLLDEAIDARIELAQRTLAAMLGAQRPSINKILKEF
ERDRLITVGYAVIEITDQHGLRARAQ"
gene 1901047..1901751
/locus_tag="Rv1676"
CDS 1901047..1901751
/codon_start=1
/transl_table=11
/locus_tag="Rv1676"
/product="Unknown protein"
/note="Rv1676, (MTV047.11), len: 234 aa. Unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1676"
/db_xref="EnsemblGenomes-Tr:CCP44441"
/db_xref="GOA:O53923"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:O53923"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44441.1"
/translation="MACPEWEISRSKRTRKPVLRPRHSVSTLTNRFLAEFCHRYGIGV
PTRLARGATVPTRRLQDINDQPVDVPAATGRTHLQFRRFAACPICHLHLRSFANRHQE
VADSGITEVVFFHSAADALRGYQSLLPFAVIADPDRVQYREFGVEKSLGAITHPRALW
AAVRGSAAMLHRNDPERAGVGFGDGTTHLGLPADFLLDADGTVAAVHYGRHADDQWSV
DQLIDINRSLGGKGTQ"
gene 1901748..1902296
/gene="dsbF"
/locus_tag="Rv1677"
CDS 1901748..1902296
/codon_start=1
/transl_table=11
/gene="dsbF"
/locus_tag="Rv1677"
/product="Probable conserved lipoprotein DsbF"
/note="Rv1677, (MTV047.12), len: 182 aa. Probable
dsbF,conserved lipoprotein possibly involved in
thiol:disulfide interchange. Highly similar to C-terminus
of Z74024|MTCY274.09 mpt53 soluble secreted antigen
precursor from Mycobacterium tuberculosis (173 aa), FASTA
scores: opt: 482, E(): 3.6e-23, (52.8% identity in 142 aa
overlap) . Also some similarity to P52237|TIPB_PSEFL
thiol:disulfide interchange protein TIPB precursor from
Pseudomonas fluorescens (178 aa), FASTA scores: opt: 190,
E(): 4.4e-05,(28.5% identity in 151 aa overlap); and
P33926|DSBE_ECOLI thiol:disulfide interchange protein from
Escherichia coli (185 aa), FASTA scores: opt: 194, E():
2.6e-05, (29.1% identity in 175 aa overlap). Contains
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site and PS00194 Thioredoxin family active site.
Nucleotide position 1901816 in the genome sequence has
been corrected, A:G resulting in Q23Q."
/db_xref="EnsemblGenomes-Gn:Rv1677"
/db_xref="EnsemblGenomes-Tr:CCP44442"
/db_xref="GOA:I6XYM2"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR017937"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:I6XYM2"
/inference="protein motif:PROSITE:PS00013"
/inference="protein motif:PROSITE:PS00194"
/protein_id="CCP44442.1"
/translation="MTHSRLIGALTVVAIIVTACGSQPKSQPAVAPTGDAAAATQVPA
GQTVPAQLQFSAKTLDGHDFHGESLLGKPAVLWFWAPWCPTCQGEAPVVGQVAASHPE
VTFVGVAGLDQVPAMQEFVNKYPVKTFTQLADTDGSVWANFGVTQQPAYAFVDPHGNV
DVVRGRMSQDELTRRVTALTSR"
gene 1902397..1903299
/locus_tag="Rv1678"
CDS 1902397..1903299
/codon_start=1
/transl_table=11
/locus_tag="Rv1678"
/product="Probable integral membrane protein"
/note="Rv1678, (MTV047.13), len: 300 aa. Probable integral
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1678"
/db_xref="EnsemblGenomes-Tr:CCP44443"
/db_xref="GOA:O53925"
/db_xref="UniProtKB/TrEMBL:O53925"
/protein_id="CCP44443.1"
/translation="MARVRRGTELLLSPQSPPATGGLIVLTGLRLLAGLIWLYNVVWK
VPPDFGERGRRDLYHFTHLAVEHPVFTPFSWVIEHAVLPYFTAFGWGVLFAESALAVL
LLTGTAVRLAALIGIGQSVAIGLSVAESPGEWPWAYAMLLGIHVVLLFTCSTRYAAVD
AVRAAATGSAARTAAQRLLAGWGIVLGLIGLVAVWRGLGDDRPAYVGIRALEFSLGEY
NLRGALALIAIALAMLAAAKRGWRTVALVAAVVAVAAAAAIYLQVGRTAVWLGGTNTT
AAVFVCAAVVSLATEFRIGRVEGA"
gene 1903299..1904420
/gene="fadE16"
/locus_tag="Rv1679"
CDS 1903299..1904420
/codon_start=1
/transl_table=11
/gene="fadE16"
/locus_tag="Rv1679"
/product="Possible acyl-CoA dehydrogenase FadE16"
/note="Rv1679, (MTV047.14, MTCI125.01), len: 373 aa.
Possible fadE16, acyl-CoA dehydrogenase, similar to
acyl/butyryl-CoA dehydrogenases e.g. NP_244665.1|NC_002570
acyl-CoA dehydrogenase from Bacillus halodurans (380 aa);
NP_000008.1|NM_000017 acyl-Coenzyme A dehydrogenase from
Homo sapiens (412 aa); Z99113|BSUB0010_119 from Bacillus
subtilis (380 aa), FASTA scores: opt: 439, E():
3.4e-20,(29.6% identity in 287 aa overlap); etc. Weakly
similar to many dehydrogenases and to P31571|CAIA_ECOLI
probable carnitine operon oxidoreductase from Escherichia
coli (380 aa), FASTA scores: opt: 109, E(): 0.0066, (28.6%
identity in 98 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1679"
/db_xref="EnsemblGenomes-Tr:CCP44444"
/db_xref="GOA:O53926"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:O53926"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44444.1"
/translation="MATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLV
LPREIGGMGSGPVEFTEVVAQLSAACGSTAMIYLMHMAAAVTVAASPPPGLPDLLADM
ASGKQLGTLAFSEPGSRSHFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGS
ADGAAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGF
GIMMQTVLPWFNLGNAAVSLGLATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIAR
MGTTLAAQKAYLEVAANSVSSPDDTTLTHVLGVKASVNDAALTITESAMRVCGGAAFS
KHLPIERAFRDARAGSVMAPTADALYDFYGRAVTGLPLF"
gene 1904429..1905253
/locus_tag="Rv1680"
CDS 1904429..1905253
/codon_start=1
/transl_table=11
/locus_tag="Rv1680"
/product="Hypothetical protein"
/note="Rv1680, (MTCI125.02), len: 274 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1680"
/db_xref="EnsemblGenomes-Tr:CCP44445"
/db_xref="UniProtKB/TrEMBL:O33182"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44445.1"
/translation="MSTEPLVVGAVAYTPNVVPIWEGIRGYFQDSESPDTQMDFVLYS
NYARLVDSLIAGHIDIAWNTNLAYVRTVLQTGGRCTPLAQRDTDVDYTTVFVAHAGSD
LHGAKDIAGKRLALGSADSAHAAILPLYYLRRAGIAESDLQVIRFDTDIGKHGDTGRS
ELDAVDAVLAGEADVAAIGSSTWAAMGAAELMGESLTEVWRTDGYCHCMFTALDTLPA
ERYQPWLDRLLAMSWDDSEHRKILELEGLRRWVPPHLDGYKPLFEAVQEQGIDPRW"
gene 1905250..1906242
/gene="moeX"
/locus_tag="Rv1681"
CDS 1905250..1906242
/codon_start=1
/transl_table=11
/gene="moeX"
/locus_tag="Rv1681"
/product="Possible molybdopterin biosynthesis protein
MoeX"
/note="Rv1681, (MTCI125.03), len: 330 aa. Possible
moeX,Molybdopterin biosynthesis protein, has weak
similarity to MOAA_ECOLI|P30745 molybdenum cofactor
biosynthesis protein (329 aa), FASTA scores: opt: 162,
E(): 0.00081, (27.7% identity in 224 aa overlap) and to
Rv3109|MTCY164.19 MoaA from Mycobacterium tuberculosis
(28.5% identity in 165 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1681"
/db_xref="EnsemblGenomes-Tr:CCP44446"
/db_xref="GOA:O33183"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:O33183"
/protein_id="CCP44446.1"
/translation="MIIELMRRVVGLAQGATAEVAVYGDRDRDLAERWCANTGNTLVR
ADVDQTGVGTLVVRRGHPPDPASVLGPDRLPGVRLWLYTNFHCNLCCDYCCVSSSPST
PHRELGAERIGRIVGEAARWGVRELFLTGGEPFLLPDIDTIIATCVKQLPTTVLTNGM
VFKGRGRRALESLPRGLALQISLDSATPELHDAHRGAGTWVKAVAGIRLALSLGFRVR
VAATVASPAPGELTAFHDFLDGLGIAPGDQLVRPIALEGAASQGVALTRESLVPEVTV
TADGVYWHPVAATDERALVTRTVEPLTPALDMVSRLFAEQWTRAAEEAALFPCA"
gene 1906403..1907320
/locus_tag="Rv1682"
CDS 1906403..1907320
/codon_start=1
/transl_table=11
/locus_tag="Rv1682"
/product="Probable coiled-coil structural protein"
/note="Rv1682, (MTCI125.04), len: 305 aa. Probable
coiled-coil structural protein, weakly similar to many
paramyosins, kinesins and plectins e.g. MYSP_ONCVO|Q02171
paramyosin from onchocerca volvulus (879 aa), fasta
scores: opt: 180, E():2.6e-08, (24.4% identity in 234 aa
overlap). Also similar to Mycobacterium tuberculosis
hypothetical coiled-coil proteins (wag31 antigen 84)
Rv2145c and Rv2927c."
/db_xref="EnsemblGenomes-Gn:Rv1682"
/db_xref="EnsemblGenomes-Tr:CCP44447"
/db_xref="InterPro:IPR007793"
/db_xref="UniProtKB/TrEMBL:O33184"
/protein_id="CCP44447.1"
/translation="MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQRTRSGYDP
VAVNHYIAELVLRQQAQHCEIETLKAEIASLKDENAALKDTSPSAQAVTDRMAKMLRL
AVDEVFQMQSEARAEAATLVSAARDEAEAVRTQKREMLADMNARQRALESEHADVMRR
AREEAEQLVAQATAEVERMRVIDARRREKAEQELDAEIIRLRTDAQFQIDDQLQATQQ
ECEKRLGEAKIEADRRLHVADEQIEHGLSEARRTLEEISQRRVGILEQLARIHAQLEN
IPALLESARHSETEPLQSINGAVAELRAI"
repeat_region 1907460..1907515
/note="56 bp direct repeat 1,
AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT"
repeat_region 1907516..1907571
/note="56 bp direct repeat 2,
AGTCGGGTGACGATGCGGGCCGGTGTGGTCCGAGGAGGAGCCCGACAATTTAAGCT"
gene 1907594..1910593
/locus_tag="Rv1683"
CDS 1907594..1910593
/codon_start=1
/transl_table=11
/locus_tag="Rv1683"
/product="Possible bifunctional enzyme; long-chain
acyl-CoA synthase and lipase."
/note="Rv1683, (MTCI125.05), len: 999 aa. Possible
bifunctional long-chain acyl-CoA synthase and lipase.
Equivalent to Z95117|MLCB1351_21 possible long-chain
acyl-CoA synthase from Mycobacterium leprae (1002 aa)
(85.6% identity in 1002 aa overlap). Weakly similar to
FATP_MOUSE|Q60714 long-chain fatty acid transport protein
(646 aa), fasta scores: opt: 331, E(): 5e-08, (24.8%
identity in 630 aa overlap). Also similar to
O35488|AF033031 Mouse very-long-chain acyl-CoA synthetase
(620 aa), fasta scores: opt: 435, E(): 2.2e-12, (24.8%
identity in 545 aa overlap). Weakly similar to
Mycobacterium tuberculosis protein MTCI364.18 (27.4%
identity in 583 aa overlap). Contains PS00120
Lipases,serine active site."
/db_xref="EnsemblGenomes-Gn:Rv1683"
/db_xref="EnsemblGenomes-Tr:CCP44448"
/db_xref="GOA:O33185"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O33185"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44448.1"
/translation="MVDLNFSMVTRPIERLVATAQNGLEVLRLGGLETGSVPSPSQIV
ESVPMYKLRRYFPPDNRPGQPPVGPPVLMVHPMMMSADMWDVTREDGAVGILHASGLD
PWVIDFGSPDEVEGGMRRNLADHIVALSEAVDTVKDATGHDVHFVGYSQGGMFCYQAA
AYRRSKDIASVVAFGSPVDTLAALPMGIPANMGAAVADFMADHVFNRLDIPSWMARMG
FQMMDPLKTAKARVDFVRQLHDREALLPREQQRRFLESEGWIAWSGPAISELLKQFIA
HNRMMTGGFAISGQMVTLTDITCPILAFVGEVDDIGQPASVRGIRRAAPNSEVYECLI
RAGHFGLVVGSRAAQQSWPTVADWVRWISGDGTKPENIHLMADQPAEHTDSGVAFSSR
VAHGIGEVSEAALALARGAADAVVAANRSVRTLAVETVRTLPRLARLGQLNDHTRISL
GRIIDEQAHDAPKGEFLLFDGRVHTYEAVNRRINNVVRGLIAVGVRQGDRVGVLMETR
PSALVAIAALSRLGAVAVVMRPDTDLSASVRLGRVTEILTDPTNLDAARQLPGQVLVL
GGGESRDLDLPADALEQGQVIDMEKIDPDAVELPAWYRPNPGLARDLAFIAFSSADGD
LVAKQITNYRWAVSAFGTASTAALGRRDTVYCLTPLHHESALLVSLGGAVVGGTRIAL
SRGLRPDRFVAEVRQYGVTVVSYTWAMLRDVVDDPAFVLHGNHPVRLFIGSGMPTGLW
ERVVEAFAPAHVVEFFATTDGQAVLANVAGAKIGSKGRPLPGAGRVELGAYDAEHDLI
LENDRGFVQVAGVNQVGVLLAQSRGPIDPTASVKRGVFAPADTWISTDYLFWRDDDGD
YWLAGGRGSVVRTARGMVYTEPVTNALGLITGVDLAVTYGVLVRGRHVAVSAVTLLPG
ATITAADLTEAVASMPVGLGPDIVHVVPQLTLSGTYRPTVSALRANGIPKAGRQAWYF
NSGGNEYRRLTPAVRTELTGQHRRGNA"
gene 1910586..1910810
/locus_tag="Rv1684"
CDS 1910586..1910810
/codon_start=1
/transl_table=11
/locus_tag="Rv1684"
/product="Conserved hypothetical protein"
/note="Rv1684, (MTCI125.06), len: 74 aa. Conserved
hypothetical protein, similar to P75844|YCAR_ECOLI Protein
YCAR from Escherichia coli (60 aa), FASTA scores: opt:
108,E(): 0.00022, (39.0% identity in 59 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1684"
/db_xref="EnsemblGenomes-Tr:CCP44449"
/db_xref="GOA:O33186"
/db_xref="InterPro:IPR005651"
/db_xref="UniProtKB/TrEMBL:O33186"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44449.1"
/translation="MLDEALLAILVCPADRGPLVLVEDGDIQVLYNPRLRRAYRIEDG
IPVLLVDEAREVDEDEHARLMARGRPAAPQ"
gene complement(1910776..1911399)
/locus_tag="Rv1685c"
CDS complement(1910776..1911399)
/codon_start=1
/transl_table=11
/locus_tag="Rv1685c"
/product="Conserved hypothetical protein"
/note="Rv1685c, (MTCI125.07c), len: 207 aa. Conserved
hypothetical protein, some similarity to other
Mycobacterium tuberculosis hypothetical regulatory
proteins e.g. Q10774|Rv1556|YF56_MYCTU (202 aa), FASTA
scores: opt: 111, E(): 1.7e-05, (24.1% identity in 195 aa
overlap); and P95215|Rv0258c|MTCY06A4.02c (151 aa) FASTA
scores: (32.9% identity in 140 aa overlap); also similar
to Q9X8G9|SCE7.13C|AL049819 putative Streptomyces
coelicolor transcriptional regulator (204 aa), FASTA
scores: opt: 480,E(): 6.4e-25, (40.4% identity in 203 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1685c"
/db_xref="EnsemblGenomes-Tr:CCP44450"
/db_xref="GOA:O33187"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041678"
/db_xref="UniProtKB/TrEMBL:O33187"
/protein_id="CCP44450.1"
/translation="MAAPDNSRRRPGRPAGSSDTRERILSSARELFAHNGIDRTSIRA
VAAKAGVDAALVHHYFGTKQQLFAAAIHIPIDPMVIIGPIREAPVEELGYKLPSLLLP
IWDSELGAGLIATLRSLISGSDVGLARSFLEEVVTVELGSRVDNPPGTGKIRTQFVAS
QLMGVVMARYIVRIEPFASLPAEQIVQTIAPNLQRYLTGELPDDLAP"
gene complement(1911401..1912081)
/locus_tag="Rv1686c"
CDS complement(1911401..1912081)
/codon_start=1
/transl_table=11
/locus_tag="Rv1686c"
/product="Probable conserved integral membrane protein ABC
transporter"
/note="Rv1686c, (MTCI125.08c), len: 226 aa. Probable
conserved integral membrane protein ABC transporter (see
citation below), similar to AL049819|SCE7.05 putative
integral membrane protein from Streptomyces coelicolor
(266 aa), FASTA sacores: opt: 661, E(): 0, (45.1% identity
in 226 aa overlap); and Q53627|U43537 membrane protein
involved in mithramycin resistance from streptomyces
argillaceus (233 aa), FASTA scores: opt: 222, E():
5.4e-10,(28.7% identity in 216 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1686c"
/db_xref="EnsemblGenomes-Tr:CCP44451"
/db_xref="GOA:O33188"
/db_xref="InterPro:IPR000412"
/db_xref="InterPro:IPR004377"
/db_xref="InterPro:IPR013525"
/db_xref="UniProtKB/TrEMBL:O33188"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44451.1"
/translation="MILLVPILIITLMYFMFENVPHRPGTPSGFNTACLVLLGLFPLF
VMFVITAITMQRERASGTLERILTTPLRRLDLLAGYGTAFSIAAAAQATLACIVAFWF
LGFDTAGSPVWVFAIAIVNAVLGVGLGLLCSAFARTEFQAVQFIPLVMVPQLLLAGII
VPRALMPTWLEWISNVMPASYALEALQQVGAHPELTGIAVRDVVVVLSFAVASLCLAA
VTLRRRTS"
gene complement(1912153..1912920)
/locus_tag="Rv1687c"
CDS complement(1912153..1912920)
/codon_start=1
/transl_table=11
/locus_tag="Rv1687c"
/product="Probable conserved ATP-binding protein ABC
transporter"
/note="Rv1687c, (MTCI125.09c), len: 255 aa. Probable
conserved ATP-binding protein ABC transporter (see
citation below), similar to many ABC-type transporters
e.g. P55476|NODI_RHISN nodulation ATP-binding protein I
from Rhizobium sp. (343 aa), FASTA scores: opt: 479, E():
3.7e-23, (34.6% identity in 243 aa overlap); etc. Also
similar to many other Mycobacterium tuberculosis ABC-type
transporters e.g. MTCY19H9.04 (34.5% identity in 238 aa
overlap). Contains PS00211 ABC transporters family
signature and PS00017 ATP/GTP-binding site motif A
(P-loop). Belongs to the ATP-binding transport protein
family (ABC transporters). Also contains PS00039 dead-box
subfamily ATP-dependent helicases signature, though this
may be spurious."
/db_xref="EnsemblGenomes-Gn:Rv1687c"
/db_xref="EnsemblGenomes-Tr:CCP44452"
/db_xref="GOA:O33189"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O33189"
/inference="protein motif:PROSITE:PS00039"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44452.1"
/translation="MMISSSDELLRDGADPAVIIDQLRVIRGKRLALQDVSVRVACGT
ITGLLGPSGSGKTTLIRCIVGSQIIASGSVSVLGQPAGSAELRHRVGYMPQDPTIYND
LRVIDNIRYFAELCGVDRQAADEVIEAVDLRDHRTARCANLSGGQRARVSLACALVGR
PDLLVLDEPTIGLDPVLRVELWDRFTALARRGTTLLVSSHVMDEADRCGDLLLLRQGQ
LLAHTTPHRLRKETGCTSLEEAFLSIVRRTTTVPAAG"
gene 1912979..1913590
/gene="mpg"
/locus_tag="Rv1688"
CDS 1912979..1913590
/codon_start=1
/transl_table=11
/gene="mpg"
/locus_tag="Rv1688"
/product="Possible 3-methyladenine DNA glycosylase Mpg"
/note="Rv1688, (MTCI125.10), len: 203 aa. Possible
mpg,3-methyladenine DNA glycosylase (see citation
below),similar to several eukaryotic 3-methylpurine DNA
glycosylases and 3-methyladenine DNA glycosylases e.g.
Q39147|X76169 3-methyladenine glycosylase from Arabidobsis
thaliana (254 aa), FASTA scores: opt: 297, E():
8.3e-15,(31.8% identity in 198 aa overlap) and
P29372|3MG_HUMAN dna-3-methyladenine glycosidase (298 aa),
FASTA scores: opt: 220, E(): 7.2e-05, (36.4% identity in
184 aa overlap). Belongs to the mpg family of DNA
glycosylases."
/db_xref="EnsemblGenomes-Gn:Rv1688"
/db_xref="EnsemblGenomes-Tr:CCP44453"
/db_xref="GOA:P9WJP7"
/db_xref="InterPro:IPR003180"
/db_xref="InterPro:IPR011034"
/db_xref="InterPro:IPR036995"
/db_xref="UniProtKB/Swiss-Prot:P9WJP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44453.1"
/translation="MNAEELAIDPVAAAHRLLGATIAGRGVRAMVVEVEAYGGVPDGP
WPDAAAHSYRGRNGRNDVMFGPPGRLYTYRSHGIHVCANVACGPDGTAAAVLLRAAAI
EDGAELATSRRGQTVRAVALARGPGNLCAALGITMADNGIDLFDPSSPVRLRLNDTHR
ARSGPRVGVSQAADRPWRLWLTGRPEVSAYRRSSRAPARGASD"
gene 1913602..1914876
/gene="tyrS"
/locus_tag="Rv1689"
CDS 1913602..1914876
/codon_start=1
/transl_table=11
/gene="tyrS"
/locus_tag="Rv1689"
/product="Probable tyrosyl-tRNA synthase TyrS (TYRRS)"
/note="Rv1689, (MTCI125.11), len: 424 aa. Probable
tyrS,Tyrosyl-tRNA synthase, highly similar to many e.g.
SYY_ECOLI|P00951 Escherichia coli (423 aa), FASTA scores:
opt: 1271, E(): 0, (47.3% identity in 419 aa overlap).
Contains PS00178 Aminoacyl-transfer RNA synthetases
class-I signature. Belongs to class-I aminoacyl-tRNA
synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv1689"
/db_xref="EnsemblGenomes-Tr:CCP44454"
/db_xref="GOA:P9WFT1"
/db_xref="InterPro:IPR001412"
/db_xref="InterPro:IPR002305"
/db_xref="InterPro:IPR002307"
/db_xref="InterPro:IPR002942"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR024088"
/db_xref="InterPro:IPR024107"
/db_xref="InterPro:IPR036986"
/db_xref="PDB:2JAN"
/db_xref="UniProtKB/Swiss-Prot:P9WFT1"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44454.1"
/translation="MSGMILDELSWRGLIAQSTDLDTLAAEAQRGPMTVYAGFDPTAP
SLHAGHLVPLLTLRRFQRAGHRPIVLAGGATGMIGDPRDVGERSLNEADTVAEWTERI
RGQLERFVDFDDSPMGAIVENNLEWTGSLSAIEFLRDIGKHFSVNVMLARDTIRRRLA
GEGISYTEFSYLLLQANDYVELHRRHGCTLQIGGADQWGNIIAGVRLVRQKLGATVHA
LTVPLVTAADGTKFGKSTGGGSLWLDPQMTSPYAWYQYFVNTADADVIRYLRWFTFLS
ADELAELEQATAQRPQQRAAQRRLASELTVLVHGEAATAAVEHASRALFGRGELARLD
EATLAAALRETTVAELKPGSPDGIVDLLVASGLSASKGAARRTIHEGGVSVNNIRVDN
EEWVPQSSDFLHGRWLVLRRGKRSIAGVERIG"
gene complement(1914962..1915190)
/gene="G2"
ncRNA complement(1914962..1915190)
/gene="G2"
/product="Putative small regulatory RNA"
/note="G2, putative small regulatory RNA (See Arnvig and
Young, 2009). Alternate 5'-end at position 1915028.
Alternate 3'-end at position 1914977."
/ncRNA_class="other"
gene 1915527..1915910
/gene="lprJ"
/locus_tag="Rv1690"
CDS 1915527..1915910
/codon_start=1
/transl_table=11
/gene="lprJ"
/locus_tag="Rv1690"
/product="Probable lipoprotein LprJ"
/note="Rv1690, (MTCI125.12), len: 127 aa. Probable
lprJ,lipoprotein; contains possible signal sequence and
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site. Weakly similar to other Mycobacterium tuberculosis
hypothetical proteins with conserved cysteines e.g.
Rv1804c, Rv1810, Rv3354, etc"
/db_xref="EnsemblGenomes-Gn:Rv1690"
/db_xref="EnsemblGenomes-Tr:CCP44455"
/db_xref="GOA:O33192"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/Swiss-Prot:O33192"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44455.1"
/translation="MTAHTHDGTRTWRTGRQATTLLALLAGVFGGAASCAAPIQADMM
GNAFLTALTNAGIAYDQPATTVALGRSVCPMVVAPGGTFESITSRMAEINGMSRDMAS
TFTIVAIGTYCPAVIAPLMPNRLQA"
gene 1915949..1916701
/locus_tag="Rv1691"
CDS 1915949..1916701
/codon_start=1
/transl_table=11
/locus_tag="Rv1691"
/product="Conserved hypothetical protein"
/note="Rv1691, MTCI125.13, len: 250 aa. Conserved
hypothetical protein, similar to Q9S210|SCI51.30C|AL109848
Hypothetical protein from Streptomyces coelicolor (210
aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity
in 180 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1691"
/db_xref="EnsemblGenomes-Tr:CCP44456"
/db_xref="GOA:O33193"
/db_xref="InterPro:IPR011990"
/db_xref="UniProtKB/TrEMBL:O33193"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44456.1"
/translation="MVDDRQGRRGGRRPRSAAADNRPAFRDGPAIPPGIHARQLAPEI
RRELSTLDRATADAVACHLVAAGELIDDDPEAALRHARAARVRASRIAAVREAVGIAA
YRCGDWAQALAELRAARRMGSKSPLLALIADCERGLGRPQRAIELARGSEAVELSGDA
ADELRIVAAGARADLGQLEQALTVLSTPQLDPGRTGSTAARLFYAYAEILLALGRGDE
ALQWFLRSAAADIDGVTDAEDRVDELGAREQK"
gene 1916698..1917759
/locus_tag="Rv1692"
CDS 1916698..1917759
/codon_start=1
/transl_table=11
/locus_tag="Rv1692"
/product="Probable phosphatase"
/note="Rv1692, (MTCI125.14), len: 353 aa. Probable
phosphatase, some similarity to others e.g.
PNPP_SCHPO|Q00472 4-nitrophenylphosphatase (269 aa), FASTA
scores: opt: 214, E(): 1.3e-10, (29.5% identity in 241 aa
overlap); and to NAGD_ECOLI|P15302 nagd protein from
Escherichia coli (250 aa), FASTA scores: opt: 314, E():
9.8e-08, (28.2% identity in 245 aa overlap). Also similar
to AL109848|SCI51.28 hypothetical protein from
Streptomyces coelicolor (343 aa), FASTA scores: opt: 768,
E(): 0, (44.8% identity in 315 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1692"
/db_xref="EnsemblGenomes-Tr:CCP44457"
/db_xref="GOA:O33194"
/db_xref="InterPro:IPR006357"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="InterPro:IPR041065"
/db_xref="PDB:4I9G"
/db_xref="UniProtKB/Swiss-Prot:O33194"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44457.1"
/translation="MKSIAQEHDCLLIDLDGTVFCGRQPTGGAVQSLSQVRSRKLFVT
NNASRSADEVAAHLCELGFTATGEDVVTSAQSAAHLLAGQLAPGARVLIVGTEALANE
VAAVGLRPVRRFEDRPDAVVQGLSMTTGWSDLAEAALAIRAGALWVAANVDPTLPTER
GLLPGNGSMVAALRTATGMDPRVAGKPAPALMTEAVARGDFRAALVVGDRLDTDIEGA
NAAGLPSLMVLTGVNSAWDAVYAEPVRRPTYIGHDLRSLHQDSKLLAVAPQPGWQIDV
GGGAVTVCANGDVDDLEFIDDGLSIVRAVASAVWEARAADLHQRPLRIEAGDERARAA
LQRWSLMRSDHPVTSVGTQ"
gene 1917756..1917932
/locus_tag="Rv1693"
CDS 1917756..1917932
/codon_start=1
/transl_table=11
/locus_tag="Rv1693"
/product="Conserved hypothetical protein"
/note="Rv1693, (MTCI125.15), len: 58 aa. Conserved
hypothetical protein, shows some similarity to AL583921
hypothetical protein from Mycobacterium leprae (61 aa).
Probable coiled-coil from aa 30 to 58. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1693"
/db_xref="EnsemblGenomes-Tr:CCP44458"
/db_xref="UniProtKB/TrEMBL:O33195"
/protein_id="CCP44458.1"
/translation="MTIDPDQIRAEIDALLASLPDPADAENGPSLAELEGIARRLSEA
HEVLLAALESAEKG"
gene 1917940..1918746
/gene="tlyA"
/locus_tag="Rv1694"
CDS 1917940..1918746
/codon_start=1
/transl_table=11
/gene="tlyA"
/locus_tag="Rv1694"
/product="2'-O-methyltransferase TlyA"
/note="Rv1694, (MTCI125.16), len: 268 aa.
TlyA,2'-O-methyltransferase; cytotoxin/haemolysin
homologue (see citations below), almost identical to
NP_301968.1|NC_002677 cytotoxin/haemolysin homologue TlyA
from Mycobacterium leprae (269 aa). TlyA homologues were
also identified by PCR in Mycobacterium avium,
Mycobacterium bovis BCG, but appeared absent in M.
smegmatis, M. vaccae, M. kansasii, M. chelonae and M.
phlei (see Wren et al., 1998). Also highly similar to
CAB83047.1|AJ271681 putative haemolysin from Mycobacterium
ulcerans (281 aa); and similar to HLYA_TREHY|Q06803
pore-forming haemolysin/cytotoxin virulence determinant
from Treponema hyodysenteriae (240 aa), FASTA scores: opt:
514, E():3e-30, (37.3% identity in 236 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1694"
/db_xref="EnsemblGenomes-Tr:CCP44459"
/db_xref="GOA:P9WJ63"
/db_xref="InterPro:IPR002877"
/db_xref="InterPro:IPR002942"
/db_xref="InterPro:IPR004538"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR036986"
/db_xref="PDB:5KS2"
/db_xref="PDB:5KYG"
/db_xref="UniProtKB/Swiss-Prot:P9WJ63"
/protein_id="CCP44459.1"
/translation="MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPAT
AVSDTTALTVVTDSERAWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLD
RGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISL
ATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQEL
GWHSVGVKASPLPGPSGNVEYFLWLRTQTDRALSAKGLEDAVHRAISEGP"
gene 1918746..1919669
/gene="ppnK"
/locus_tag="Rv1695"
CDS 1918746..1919669
/codon_start=1
/transl_table=11
/gene="ppnK"
/locus_tag="Rv1695"
/product="Inorganic polyphosphate/ATP-NAD kinase PpnK
(poly(P)/ATP NAD kinase)"
/note="Rv1695, (MTCI125.17), len: 307 aa. PpnK, inorganic
polyphosphate/ATP-NAD kinase (see citation
below),equivalent to Q49897|MLC1351.13C|Z95117|PPNK_MYCLE
inorganic polyphosphate/ATP-NAD kinase from Mycobacterium
leprae (311 aa) (87.9% identity in 305 aa overlap). Also
similar to many e.g. P37768|PPNK_ECOLI probable inorganic
polyphosphate/ATP-NAD kinase (292 aa), FASTA scores: opt:
384, E(): 1.7e-23, (33.5% identity in 233 aa overlap);
etc. Belongs to the NAD kinase family."
/db_xref="EnsemblGenomes-Gn:Rv1695"
/db_xref="EnsemblGenomes-Tr:CCP44460"
/db_xref="GOA:P9WHV7"
/db_xref="InterPro:IPR002504"
/db_xref="InterPro:IPR016064"
/db_xref="InterPro:IPR017437"
/db_xref="InterPro:IPR017438"
/db_xref="PDB:1U0R"
/db_xref="PDB:1U0T"
/db_xref="PDB:1Y3H"
/db_xref="PDB:1Y3I"
/db_xref="UniProtKB/Swiss-Prot:P9WHV7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44460.1"
/translation="MTAHRSVLLVVHTGRDEATETARRVEKVLGDNKIALRVLSAEAV
DRGSLHLAPDDMRAMGVEIEVVDADQHAADGCELVLVLGGDGTFLRAAELARNASIPV
LGVNLGRIGFLAEAEAEAIDAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNE
VSLEKGPRLGVLGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAI
LVVPNNAHALFGRPMVTSPEATIAIEIEADGHDALVFCDGRREMLIPAGSRLEVTRCV
TSVKWARLDSAPFTDRLVRKFRLPVTGWRGK"
gene 1919683..1921446
/gene="recN"
/locus_tag="Rv1696"
CDS 1919683..1921446
/codon_start=1
/transl_table=11
/gene="recN"
/locus_tag="Rv1696"
/product="Probable DNA repair protein RecN (recombination
protein N)"
/note="Rv1696, (MTCI125.18), len: 587 aa. Probable
recN,DNA repair protein (see citation below), similar to
many e.g. RECN_ECOLI|P05824 dna repair protein recN (553
aa),FASTA scores: opt: 508, E(): 1.9e-33, (31.5% identity
in 587 aa overlap). Equivalent to Z95117|MLCB1351_12 recN
from Mycobacterium leprae (587 aa), FASTA scores: (76.1%
identit y in 589 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv1696"
/db_xref="EnsemblGenomes-Tr:CCP44461"
/db_xref="GOA:P9WHI7"
/db_xref="InterPro:IPR003395"
/db_xref="InterPro:IPR004604"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WHI7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44461.1"
/translation="MLTELRIESLGAISVATAEFDRGFTVLTGETGTGKTMVVTGLHL
LGGARADATRVRSGADRAVVEGRFTTTDLDDATVAGLQAVLDSSGAERDEDGSVIALR
SISRDGPSRAYLGGRGVPAKSLSGFTNELLTLHGQNDQLRLMRPDEQRGALDRFAAAG
EAVQRYRKLRDAWLTARRDLVDRRNRARELAQEADRLKFALNEIDTVDPQPGEDVALV
ADIARLSELDTLREAATTARATLCGTPDADAFDRGAVDSLGRARAALQSSDDAALRGL
AEQVGEALTVVVDAVAELGAYLDELPADASALDAKLARQAQLRTLTRKYAADIDGVLR
WADEARARLAQLDVSEEGLAALERRTGELAHELGQAAVDLSTIRRKAAKRLAKEVSAE
LSALAMADAEFTIGVTTELADHGDPVALALASGELARAGADGVDAVEFGFVAHRGMTV
LPLAKSASGGELSRVMLSLEVVLATSRKQAAGTTMVFDEIDAGVGGWAAVQIGRRLAR
LARTHQVIVVTHLPQVAAYADVHLMVQRTGRDGASGVRRLTSEDRVAELARMLAGLGD
SDSGRAHARELLETAQNDELT"
gene 1921542..1922723
/locus_tag="Rv1697"
CDS 1921542..1922723
/codon_start=1
/transl_table=11
/locus_tag="Rv1697"
/product="Conserved hypothetical protein"
/note="Rv1697, (MTCI125.19), len: 393 aa. Conserved
hypothetical protein, highly similar to
Q49895|MLC1351.11C|U00021 Hypothetical protein of
Mycobacterium leprae from cosmid L247 (430 aa), FASTA
scores: opt: 2345, E(): 0, (90.6% identity in 393 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1697"
/db_xref="EnsemblGenomes-Tr:CCP44462"
/db_xref="GOA:O33198"
/db_xref="InterPro:IPR022215"
/db_xref="InterPro:IPR036759"
/db_xref="UniProtKB/TrEMBL:O33198"
/protein_id="CCP44462.1"
/translation="MRMSALLSRNTSRPGLIGIARVDRNIDRLLRRVCPGDIVVLDVL
DLDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPEIFKKVKD
GAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAHLEAFAGNTIEFIRSE
SPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDLKSLKPFIKEYQPVLVGVGTGADV
LRKAGYRPQLIVGDPDQISTEVLKCGAQVVLPADADGHAPGLERIQDLGVGAMTFPAA
GSATDLALLLADHHGAALLVTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAK
AVATLYRNHISGGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLV
S"
gene 1922745..1923689
/gene="mctB"
/locus_tag="Rv1698"
CDS 1922745..1923689
/codon_start=1
/transl_table=11
/gene="mctB"
/locus_tag="Rv1698"
/product="Outer membrane protein MctB"
/note="Rv1698, (MTCI125.20), len: 314 aa.
MctB,mycobacterial copper transport protein B essential
for Cu resistance and maintenance of low intracellular Cu
levels (See Wolschendorf et al., 2011). Outer membrane
protein (See Siroy et al., 2008) with predicted N-terminal
signal sequence. Probable coiled-coil from aa 31 to 67. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004). Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1698"
/db_xref="EnsemblGenomes-Tr:CCP44463"
/db_xref="GOA:P9WJ83"
/db_xref="InterPro:IPR021522"
/db_xref="UniProtKB/Swiss-Prot:P9WJ83"
/protein_id="CCP44463.1"
/translation="MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDL
YTQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAV
SKIVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGD
LLGIALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALS
TDAGNQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDI
DAEPGRITVILALHDLINGGHVGHYGTGHGAMSVTVSQ"
gene 1923829..1925589
/gene="pyrG"
/locus_tag="Rv1699"
CDS 1923829..1925589
/codon_start=1
/transl_table=11
/gene="pyrG"
/locus_tag="Rv1699"
/product="Probable CTP synthase PyrG"
/note="Rv1699, (MTCI125.21), len: 586 aa. Probable
pyrG,CTP synthase highly similar to many e.g.
PYRG_ECOLI|P08398 ctp synthase from Escherichia coli (544
aa), FASTA scores: opt: 1786, E():0, (51.8% identity in
548 aa overlap). Contains PS00442 Glutamine
amidotransferases class-I active site."
/db_xref="EnsemblGenomes-Gn:Rv1699"
/db_xref="EnsemblGenomes-Tr:CCP44464"
/db_xref="GOA:P9WHK7"
/db_xref="InterPro:IPR004468"
/db_xref="InterPro:IPR017456"
/db_xref="InterPro:IPR017926"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029062"
/db_xref="InterPro:IPR033828"
/db_xref="PDB:4ZDI"
/db_xref="PDB:4ZDJ"
/db_xref="PDB:4ZDK"
/db_xref="UniProtKB/Swiss-Prot:P9WHK7"
/inference="protein motif:PROSITE:PS00442"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44464.1"
/translation="MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTM
QKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRNLPGSANVTTGQVY
STVIAKERRGEYLGDTVQVIPHITDEIKRRILAMAQPDADGNRPDVVITEIGGTVGDI
ESQPFLEAARQVRHYLGREDVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPD
ALILRCDRDVPEALKNKIALMCDVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRL
NLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSVAEALRAGGFKHRAK
VEICWVASDGCETTSGAAAALGDVHGVLIPGGFGIRGIEGKIGAIAYARARGLPVLGL
CLGLQCIVIEAARSVGLTNANSAEFDPDTPDPVIATMPDQEEIVAGEADLGGTMRLGS
YPAVLEPDSVVAQAYQTTQVSERHRHRYEVNNAYRDKIAESGLRFSGTSPDGHLVEFV
EYPPDRHPFVVGTQAHPELKSRPTRPHPLFVAFVGAAIDYKAGELLPVEIPEIPEHTP
NGSSHRDGVGQPLPEPASRG"
gene 1925582..1926205
/locus_tag="Rv1700"
CDS 1925582..1926205
/codon_start=1
/transl_table=11
/locus_tag="Rv1700"
/product="NUDIX hydrolase"
/note="Rv1700, (MTCI125.22), len: 207 aa. Nudix
hydrolase,equivalent to Q49891|MLC1351.08C|Z95117
Hypothetical protein from Mycobacterium leprae (177 aa),
FASTA scores: (66.7% identity in 171 aa overlap); also
similar to Q9S225|SCI51.15C|AL109848 Hypothetical protein
from Streptomyces coelicolor (211 aa), FASTA scores: opt:
508,E(): 1.2e-27, (43.1% identity in 197 aa overlap);
similar to P54570|ADPP_BACSU ADP-ribose pyrophosphatase
(185 aa),FASTA scores: opt: 313, E(): 1.1e-06, (42.7%
identity in 124 aa overlap). Belongs to the family of
Nudix hydrolases"
/db_xref="EnsemblGenomes-Gn:Rv1700"
/db_xref="EnsemblGenomes-Tr:CCP44465"
/db_xref="GOA:I6X235"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="PDB:5I8U"
/db_xref="UniProtKB/TrEMBL:I6X235"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44465.1"
/translation="MAEHDFETISSETLHTGAIFALRRDQVRMPGGGIVTREVVEHFG
AVAIVAMDDNGNIPMVYQYRHTYGRRLWELPAGLLDVAGEPPHLTAARELREEVGLQA
STWQVLVDLDTAPGFSDESVRVYLATGLREVGRPEAHHEEADMTMGWYPIAEAARRVL
RGEIVNSIAIAGVLAVHAVTTGFAQPRPLDTEWIDRPTAFAARRAER"
gene 1926202..1927137
/locus_tag="Rv1701"
CDS 1926202..1927137
/codon_start=1
/transl_table=11
/locus_tag="Rv1701"
/product="Probable integrase/recombinase"
/note="Rv1701, (MTCI125.23), len: 311 aa. Probable
integrase/recombinase, similar to many e.g.
XERD_ECOLI|P21891 integrase/recombinase xerd (298
aa),FASTA scores: opt: 583, E(): 0, (41.8% identity in 311
aa overlap). Also similar to other Mycobacterium
tuberculosis integrase/recombinase proteins
RV2894c|MTCY274.25c (43.1% identity in 304 aa overlap);
and Rv2646|MTCY441.16 phiRv2 integrase (31.1% identity in
161 aa overlap). Equivalent to Z95117|MLCB1351_7 from
Mycobacterium leprae (316 aa) (85.4% identity in 316 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1701"
/db_xref="EnsemblGenomes-Tr:CCP44466"
/db_xref="GOA:P9WF33"
/db_xref="InterPro:IPR002104"
/db_xref="InterPro:IPR004107"
/db_xref="InterPro:IPR010998"
/db_xref="InterPro:IPR011010"
/db_xref="InterPro:IPR011932"
/db_xref="InterPro:IPR013762"
/db_xref="InterPro:IPR023009"
/db_xref="UniProtKB/Swiss-Prot:P9WF33"
/protein_id="CCP44466.1"
/translation="MKTLALQLQGYLDHLTIERGVAANTLSSYRRDLRRYSKHLEERG
ITDLAKVGEHDVSEFLVALRRGDPDSGTAALSAVSAARALIAVRGLHRFAAAEGLAEL
DVARAVRPPTPSRRLPKSLTIDEVLSLLEGAGGDKPSDGPLTLRNRAVLELLYSTGAR
ISEAVGLDLDDIDTHARSVLLRGKGGKQRLVPVGRPAVHALDAYLVRGRPDLARRGRG
TAAIFLNARGGRLSRQSAWQVLQDAAERAGITAGVSPHMLRHSFATHLLEGGADVRVV
QELLGHASVTTTQIYTLVTVHALREVWAGAHPRAR"
gene complement(1927211..1928575)
/locus_tag="Rv1702c"
CDS complement(1927211..1928575)
/codon_start=1
/transl_table=11
/locus_tag="Rv1702c"
/product="Conserved hypothetical protein"
/note="Rv1702c, (MTCI125.24c), len: 454 aa. Conserved
hypothetical ORF in REP13E12 degenerate repeat. Similar to
other hypothetical proteins inside REP13E12 elements
(often in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317
aa),FASTA scores: opt: 1284, E(): 0, (59.7% identity in
315 aa overlap); and Rv1128c, Rv1945, Rv1148c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1702c"
/db_xref="EnsemblGenomes-Tr:CCP44467"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P9WLT3"
/protein_id="CCP44467.1"
/translation="MYSSSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCE
KIRRRLPAAEHPFINKLADQTDQTELGGKLPFALAERLHISRGEASRRIHEAADLGPR
RTLTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATL
GGRFRPDQLHKLATKLADCLNPDGNYNDTDRARRRSIILGNQGPDGMSAISGYLTPEA
RATVDAVLAKLAAPGMANPADDTPCLAGTPSQAAIEADTRSAGQRHHDGLLAALRALL
CSGELGQHNGLPAAIIVSTSLTELQSRAGHALTGGGTLLPMSDVIRLASHANHYLRIF
DHGRELALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVTDFAQCQETDI
NELTQGCGPHHQLATTGGWITRKRKDGTTEWLPPAHLDHGQPRTNSYFHPEKLLHDSD
EDDP"
repeat_region 1927218..1928589
/note="REP-6, len: 1372 nt. REPI125, member of REP13E12
family."
gene complement(1929131..1929721)
/locus_tag="Rv1703c"
CDS complement(1929131..1929721)
/codon_start=1
/transl_table=11
/locus_tag="Rv1703c"
/product="Probable catechol-O-methyltransferase"
/note="Rv1703c, (MTCI125.25c), len: 196 aa. Probable
catechol-o-methyltransferase, most similar to
COMT_HUMAN|P21964 soluble form of mammalian catechol
o-methyltransferase (271 aa), FASTA scores: opt: 405, E():
7.8e-29, (38.9% identity in 190 aa overlap). Also similar
to Mycobacterium tuberculosis hypothetical
methyltransferases Rv0187, Rv1220c."
/db_xref="EnsemblGenomes-Gn:Rv1703c"
/db_xref="EnsemblGenomes-Tr:CCP44468"
/db_xref="GOA:L0TAD5"
/db_xref="InterPro:IPR002935"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:L0TAD5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44468.1"
/translation="MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTY
LGYGALRIARAAPEARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLD
ALTEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRA
YMRRQQGMSWNTIEHKTHLEYQTLVPDLVLESEYLG"
gene complement(1929786..1931456)
/gene="cycA"
/locus_tag="Rv1704c"
CDS complement(1929786..1931456)
/codon_start=1
/transl_table=11
/gene="cycA"
/locus_tag="Rv1704c"
/product="Probable D-serine/alanine/glycine transporter
protein CycA"
/note="Rv1704c, (MTCI125.26c), len: 556 aa. Probable
cycA,D-serine/D-alanine/glycine transporter, highly
similar to P39312|CYCA_ECOLI d-serine/d-alanine/glycine
transporter from Escherichia coli (470 aa), FASTA scores:
opt: 1906,E(): 0, (59.3% identity in 459 aa overlap); etc.
Also similar to other Mycobacterium tuberculosis
amino-acid permeases e.g. Rv2127, Rv0346c, etc. Contains
PS00218 amino acid permeases signature. Belongs to the
amino acid permease family (APC family)."
/db_xref="EnsemblGenomes-Gn:Rv1704c"
/db_xref="EnsemblGenomes-Tr:CCP44469"
/db_xref="GOA:O33203"
/db_xref="InterPro:IPR002293"
/db_xref="InterPro:IPR004840"
/db_xref="InterPro:IPR004841"
/db_xref="UniProtKB/TrEMBL:O33203"
/inference="protein motif:PROSITE:PS00218"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44469.1"
/translation="MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSG
RTISLAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLNYKSFVDFAADLRGPAAGFFVG
WSYWFAWVVTGIADLVAITGYARFWWPGLPIWVPALVTVALILAVNLFSVRHFGELEF
WFALIKVAAIVCLIAVGAILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQI
AFFAYIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFAS
GESPFVTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTGRMLFGLADEGHAPAAFH
QLNRGGVPAPALLLTAPLLLTSIPLLYAGRSVIGAFTLVTTVSSLLFMFVWAMIIISY
LVYRRRHPQRHTDSVYKMPGGVVMCWAVLVFFAFVIWTLTTETETATALAWFPLWFVL
LAVGWLVTQRRQSRRSFGFHCQVVGVRQQLGRGMARLAMKIHARPKLRSAVVVEPVSA
GEPGARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR"
gene complement(1931497..1932654)
/gene="PPE22"
/locus_tag="Rv1705c"
CDS complement(1931497..1932654)
/codon_start=1
/transl_table=11
/gene="PPE22"
/locus_tag="Rv1705c"
/product="PPE family protein PPE22"
/note="Rv1705c, (MTCI125.27c), len: 385 aa. PPE22, Member
of the Mycobacterium tuberculosis PPE family of
glycine-rich proteins, similar to many e.g.
YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.2 3
(404 aa), fasta scores: opt: 819, E(): 0, (46.2% identity
in 413 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1705c"
/db_xref="EnsemblGenomes-Tr:CCP44470"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44470.1"
/translation="MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAELSVAAVG
YERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAASQARAAAAAYETAFA
AIVPPPLIAANRARLTSLVTHNVFGQNTASIAATEAQYAEMWAQDAMAMYGYAGSSAT
ATKVTPFAPPPNTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLPNTLLGLTSP
LSSALTAAATPGWLEWFINWYLPISQLFYNTVGLPYFAIGIGNSLITSWRALGWIGPE
AAEAAAAAPAAVGAAVGGTGPVSAGLGNAATIGKLSLPPNWAGASPSLAPTVGSASAP
LVSDIVEQPEAGAAGNLLGGMPLAGSGTGTGGAGPRYGFRVTVMSRPPFAG"
gene complement(1932694..1933878)
/gene="PPE23"
/locus_tag="Rv1706c"
CDS complement(1932694..1933878)
/codon_start=1
/transl_table=11
/gene="PPE23"
/locus_tag="Rv1706c"
/product="PPE family protein PPE23"
/note="Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member
of the Mycobacterium tuberculosis PPE family of
glycine-rich proteins, similar to many e.g.
YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23
(404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8%
identity in 408 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1706c"
/db_xref="EnsemblGenomes-Tr:CCP44471"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44471.1"
/translation="MTLDVPVNQGHVPPGSVACCLVGVTAVADGIAGHSLSNFGALPP
EINSGRMYSGPGSGPLMAAAAAWDGLAAELSSAATGYGAAISELTNMRWWSGPASDSM
VAAVLPFVGWLSTTATLAEQAAMQARAAAAAFEAAFAMTVPPPAIAANRTLLMTLVDT
NWFGQNTPAIATTESQYAEMWAQDAAAMYGYASAAAPATVLTPFAPPPQTTNATGLVG
HATAVAALRGQHSWAAAIPWSDIQKYWMMFLGALATAEGFIYDSGGLTLNALQFVGGM
LWSTALAEAGAAEAAAGAGGAAGWSAWSQLGAGPVAASATLAAKIGPMSVPPGWSAPP
ATPQAQTVARSIPGIRSAAEAAETSVLLRGAPTPGRSRAAHMGRRYGRRLTVMADRPN
VG"
gene complement(1934482..1934649)
/locus_tag="Rv1706A"
CDS complement(1934482..1934649)
/codon_start=1
/transl_table=11
/locus_tag="Rv1706A"
/product="Conserved hypothetical protein"
/note="Rv1706A, len: 55 aa. Conserved hypothetical
protein,similar to part of several probable export
proteins e.g. Rv0783c|Z80226_28 from Mycobacterium
tuberculosis (540 aa),FASTA scores: opt: 125, E(): 0.011,
(52.85% identity in 53 aa overlap). Size difference
suggests possible gene fragment."
/db_xref="EnsemblGenomes-Gn:Rv1706A"
/db_xref="EnsemblGenomes-Tr:CCP44472"
/db_xref="UniProtKB/TrEMBL:Q79FL4"
/protein_id="CCP44472.1"
/translation="MGSLAAFKLGWLLSAMAPNVVLLTAFRVPQGLTMLTVFATGQAG
QHRCRTFHVTP"
gene 1934882..1936342
/locus_tag="Rv1707"
CDS 1934882..1936342
/codon_start=1
/transl_table=11
/locus_tag="Rv1707"
/product="Probable conserved transmembrane protein"
/note="Rv1707, (MTCI125.29), len: 486 aa. Probable
conserved transmembrane protein, possibly involved in
transport of sulfate, similar to several hypothetical
proteins belonging to the sulfate permease family e.g.
P40877|YCHM_ECOLI hypothetical 58.4 kDa protein in
pth-prsa intergenic region from Escherichia coli (550 aa),
FASTA scores: opt: 486, E(): 0, (33.1% identity in 492 aa
overlap). Also similar to many other Mycobacterium
tuberculosis membrane proteins e.g. Rv3273, Rv1739c. Seems
to belong to the SulP family."
/db_xref="EnsemblGenomes-Gn:Rv1707"
/db_xref="EnsemblGenomes-Tr:CCP44473"
/db_xref="GOA:O33206"
/db_xref="InterPro:IPR001902"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR011547"
/db_xref="InterPro:IPR036513"
/db_xref="UniProtKB/TrEMBL:O33206"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44473.1"
/translation="MLQRIARELLSGVAVAIVALPLAIAFGITATGTSQGALIGLYGA
IFAGFFAAVFGGTPGQVTGPTGPITVVATATIAEHGLEGAFFAFILAGVFQILFGACR
LGSLIRYVPHPVISGFMGGIAILIIMTQLDQVRSSSLLVLVTVVLLLASGRFIKAIPP
SLLVLVLVSSVLPLAAPWLRDLRAGPVSINRTVDYIGEIPQAMPSFDFPQVANSTMLQ
VLLSAVAIALLGSLDSLLTSLVMDNIRGTRHRSNKELIGQGIGNIAAGLFGGLSGAGA
TVRSVVNVRNGGQTALSAATHSVVLFVFVAGLGAVVQYIPLAVLSGILILVAVGMFDW
HAMRKAHVSPRGDVIVMFTTMIITVVVDLTIAVMVGIALSLLVHRLRSRQRKAKVTQD
DTGTYRIDGPLSFLSVDGVFGSLRDGREDVSLDLQHVTYLDTSGARALLYFIDHSEKD
GVAVSIKRIPPRLESQLTALADNEQRDKLRTVLESA"
gene 1936360..1937316
/locus_tag="Rv1708"
CDS 1936360..1937316
/codon_start=1
/transl_table=11
/locus_tag="Rv1708"
/product="Putative initiation inhibitor protein"
/note="Rv1708, (MTCI125.30), len: 318 aa. Putative
initiation inhibitor protein, a soj-related protein
probably involved in cell process, highly similar to many
sporulation initiation inhibitor proteins soj e.g.
P37522|SOJ_BACSU Soj protein from Bacillus subtilis (253
aa), FASTA scores: opt: 745, E(): 0, (46.0% identity in
248 aa overlap), and more weakly to various repA/para/incC
proteins from various organisms e.g. Y4CK_RHISN|P55393
putative replication protein A from Rhizobium sp. (407
aa),FASTA scores: opt: 205, E(): 4e-13, (29.0% identity in
252 aa overlap). Also similar to Mycobacterium
tuberculosis hyothetical proteins Rv3213c and Rv3918c."
/db_xref="EnsemblGenomes-Gn:Rv1708"
/db_xref="EnsemblGenomes-Tr:CCP44474"
/db_xref="GOA:P9WLT1"
/db_xref="InterPro:IPR025669"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WLT1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44474.1"
/translation="MPAGLPGQASVAVRLSCDVPPDARHHEPRPGMTDHPDTGNGIGL
TGRPPRAIPDPAPRSSHGPAKVIAMCNQKGGVGKTTSTINLGAALGEYGRRVLLVDMD
PQGALSAGLGVPHYELDKTIHNVLVEPRVSIDDVLIHSRVKNMDLVPSNIDLSAAEIQ
LVNEVGREQTLARALYPVLDRYDYVLIDCQPSLGLLTVNGLACTDGVIIPTECEFFSL
RGLALLTDTVDKVRDRLNPKLDISGILITRYDPRTVNSREVMARVVERFGDLVFDTVI
TRTVRFPETSVAGEPITTWAPKSAGALAYRALARELIDRFGM"
gene 1937313..1938149
/gene="scpA"
/locus_tag="Rv1709"
CDS 1937313..1938149
/codon_start=1
/transl_table=11
/gene="scpA"
/locus_tag="Rv1709"
/product="Possible segregation and condensation protein
ScpA"
/note="Rv1709, (MTCI125.31), len: 278 aa. Possible
scpA,segregation and condensation protein, similar to e.g.
P35154|YPUG_BACSU from Bacillus subtilis (251 aa), FASTA
scores: opt: 271, E(): 8.2e-10, (27.0% identity in 248 aa
overlap); Q9S230|SCI51.10C|AL109848 from Streptomyces
coelicolor (264 aa), FASTA scores: opt: 855, E(): 0,
(56.8% identity in 257 aa overlap). Equivalent to
Q49888|MLC1351.05C|Z95117 from Mycobacterium leprae (268
aa), FASTA scores: (78.9% identity in 251 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1709"
/db_xref="EnsemblGenomes-Tr:CCP44475"
/db_xref="GOA:O33208"
/db_xref="InterPro:IPR003768"
/db_xref="UniProtKB/TrEMBL:O33208"
/protein_id="CCP44475.1"
/translation="MNGLQNSLANGGTAPENGYSAGFRVRLTNFEGPFDLLLQLIFAH
QLDVTEVALHQVTDDFIAYTKAIGARLELEETTAFLVIAATLLDLKAARLLPAGQVDD
EEDLALLEVRDLLFARLLQYRAFKHVAEMFAELEATALRSYPRAVSLEDGFVGLLPEV
MLGVDAHRFAEIAAIALTPRPAPTVATEHLHELMVSVPEQAEHLLAMLKARGSGQWAS
FSELVADCTAPIEIVGRFLALLELYRTRAVAFEQSEPLGALQVSWTGDDAERSDEKER
RL"
repeat_region 1938093..1938145
/gene="scpA"
/locus_tag="Rv1709"
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 1938146..1938841
/gene="scpB"
/locus_tag="Rv1710"
CDS 1938146..1938841
/codon_start=1
/transl_table=11
/gene="scpB"
/locus_tag="Rv1710"
/product="Possible segregation and condensation protein
ScpB"
/note="Rv1710, (MTCI125.32), len: 231 aa. Possible
scpB,segregation and condensation protein, similar to
several hypothetical proteins e.g. P35155|YPUH_BACSU from
Bacillus subtilis (197 aa), FASTA scores: opt: 339, E():
1.3e-09,(36.0% identity in 186 aa overlap);
Q9S231|SCI51.09C|AL109848 from Streptomyces coelicolor
(223 aa), FASTA scores: opt: 626, E(): 0, (51.0% identity
in 192 aa overlap). Equivalent to
O05669|MLC1351.04C|Z95117 Hypothetical protein from
Mycobacterium leprae (231 aa),FASTA scores: (77.9%
identity in 231 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1710"
/db_xref="EnsemblGenomes-Tr:CCP44476"
/db_xref="GOA:I6XCB2"
/db_xref="InterPro:IPR005234"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:I6XCB2"
/protein_id="CCP44476.1"
/translation="MTEHMPEHDPSYGIPDIAEPAELDADELKRVLEALLLVIDTPVT
ADALAAATEQPVYRVAAKLQLMADELTGRDSGIDLRHTSEGWRMYTRARFAPYVEKLL
LDGARTKLTRAALETLAVVAYRQPVTRARVSAVRGVNVDAVMRTLLARGLITEVGTDA
DTGAVTFATTELFLERLGLTSLSELPDIAPLLPDVDTIDDLSESLDSEPRFIKLTGEL
ASEQTLSFDVDRD"
gene 1938838..1939602
/locus_tag="Rv1711"
CDS 1938838..1939602
/codon_start=1
/transl_table=11
/locus_tag="Rv1711"
/product="Conserved hypothetical protein"
/note="Rv1711, (MTCI125.33), len: 254 aa. Conserved
hypothetical protein, highly similar to a large family of
hypothetical proteins e.g. P37765|YCIL_ECOLI from
Escherichia coli (291 aa), FASTA scores: opt: 496, E():
1.1e-29, (41.6% identity in 250 aa overlap);
9S232|SCI51.08C|AL109848 putative pseudouridine synthase
from Streptomyces coelicolor (371 aa), FASTA scores: opt:
818, E(): 0, (53.1% identity in 245 aa overlap).
Equivalent to O05668|MLCB1351.03C|Z95117 Hypothetical
protein from Mycobacterium leprae (256 aa), (80.5%
identity in 256 aa overlap). Contains PS01149 Hypothetical
yciL/yejD/yjbC family signature."
/db_xref="EnsemblGenomes-Gn:Rv1711"
/db_xref="EnsemblGenomes-Tr:CCP44477"
/db_xref="GOA:P9WHQ1"
/db_xref="InterPro:IPR000748"
/db_xref="InterPro:IPR002942"
/db_xref="InterPro:IPR006145"
/db_xref="InterPro:IPR018496"
/db_xref="InterPro:IPR020103"
/db_xref="InterPro:IPR036986"
/db_xref="InterPro:IPR042092"
/db_xref="UniProtKB/Swiss-Prot:P9WHQ1"
/inference="protein motif:PROSITE:PS01149"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44477.1"
/translation="MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDG
HVVTELGTRVDPQVAVVRVDGARVVLDDSLVYLALNKPRGMHSTMSDDRGRPCIGDLI
ERKVRGTKKLFHVGRLDADTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRG
LGRTLRAGIELDDGPAFVDDFAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEA
LVRTDIGAVSLGKQRPGSVRALRSNEIGQLYQAVGL"
gene 1939599..1940291
/gene="cmk"
/locus_tag="Rv1712"
CDS 1939599..1940291
/codon_start=1
/transl_table=11
/gene="cmk"
/locus_tag="Rv1712"
/product="Cytidylate kinase Cmk (CMP kinase) (cytidine
monophosphate kinase) (ck)"
/note="Rv1712, (MTCI125.34), len: 230 aa. cmk, cytidylate
kinase, highly similar to many e.g. KCY_ECOLI|P23863
cytidylate kinase from Escherichia coli (227 aa), FASTA
scores: opt: 534, E (): 0, (40.3% identity in 221 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop). Equivalent to Z95117|MLCB1351_2 from
Mycobacterium leprae (223 aa) (73.5% identity in 226 aa
overlap). Belongs to the cytidylate kinase
family,subfamily 1."
/db_xref="EnsemblGenomes-Gn:Rv1712"
/db_xref="EnsemblGenomes-Tr:CCP44478"
/db_xref="GOA:P9WPA9"
/db_xref="InterPro:IPR003136"
/db_xref="InterPro:IPR011994"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WPA9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44478.1"
/translation="MSRLSAAVVAIDGPAGTGKSSVSRRLARELGARFLDTGAMYRIV
TLAVLRAGADPSDIAAVETIASTVQMSLGYDPDGDSCYLAGEDVSVEIRGDAVTRAVS
AVSSVPAVRTRLVELQRTMAEGPGSIVVEGRDIGTVVFPDAPVKIFLTASAETRARRR
NAQNVAAGLADDYDGVLADVRRRDHLDSTRAVSPLQAAGDAVIVDTSDMTEAEVVAHL
LELVTRRSEAVR"
gene 1940288..1941679
/gene="engA"
/locus_tag="Rv1713"
CDS 1940288..1941679
/codon_start=1
/transl_table=11
/gene="engA"
/locus_tag="Rv1713"
/product="Probable GTP-binding protein EngA"
/note="Rv1713, (MTCI125.35), len: 463 aa. Probable
engA,GTP-binding protein. Equivalent to
Q49884|MLCB1351.01|U00021_5 probable GTP-binding protein
ENGA from Mycobacterium leprae (461 aa), (88.6% identity
in 463 aa overlap). And similar to many e.g.
P50743|ENGA_BACSU probable GTP-binding protein ENGA from
Bacillus subtilus (436 aa), FASTA scores: opt: 1077, E():
0, (40.6% identity in 434 aa overlap). Contains two
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the era/TRME family of GTP-binding proteins. ENGA
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv1713"
/db_xref="EnsemblGenomes-Tr:CCP44479"
/db_xref="GOA:P9WNL3"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR006073"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR016484"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031166"
/db_xref="InterPro:IPR032859"
/db_xref="UniProtKB/Swiss-Prot:P9WNL3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44479.1"
/translation="MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVN
RILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVA
MRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLG
LGEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNK
LAGDQRSVVHEAAGTTVDPVDSLIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTH
AAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWDLVDEDRRELLQRE
IDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAAT
PPPVRGGKQPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRV
NVRVREKRAGKRR"
gene 1941853..1942665
/locus_tag="Rv1714"
CDS 1941853..1942665
/codon_start=1
/transl_table=11
/locus_tag="Rv1714"
/product="Probable oxidoreductase"
/note="Rv1714, (MTV048.01), len: 270 aa. Probable
oxidoreductase similar to many e.g. AE0010|AE001021_4
Archaeoglobus fulgidus section 79 (281 aa), FASTA scores:
opt: 578, E(): 3.3e-31, (38.9% identity in 265 aa
overlap). Also similar to several other M. tuberculosis
oxidoreductases e.g. Rv1544, etc."
/db_xref="EnsemblGenomes-Gn:Rv1714"
/db_xref="EnsemblGenomes-Tr:CCP44480"
/db_xref="GOA:P9WGQ3"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGQ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44480.1"
/translation="MEEMALAQQVPNLGLARFSVQDKSILITGATGSLGRVAARALAD
AGARLTLAGGNSAGLAELVNGAGIDDAAVVTCRPDSLADAQQMVEAALGRYGRLDGVL
VASGSNHVAPITEMAVEDFDAVMDANVRGAWLVCRAAGRVLLEQGQGGSVVLVSSVRG
GLGNAAGYSAYCPSKAGTDLLAKTLAAEWGGHGIRVNALAPTVFRSAVTEWMFTDDPK
GRATREAMLARIPLRRFAEPEDFVGALIYLLSDASSFYTGQVMYLDGGYTAC"
gene 1942659..1943573
/gene="fadB3"
/locus_tag="Rv1715"
CDS 1942659..1943573
/codon_start=1
/transl_table=11
/gene="fadB3"
/locus_tag="Rv1715"
/product="Probable 3-hydroxybutyryl-CoA dehydrogenase
FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)"
/note="Rv1715, (MTV048.02), len: 304 aa. Probable
fadB3,3-hydroxybutyryl-CoA dehydrogenase, highly similar
to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA
dehydrogenase from Mesorhizobium loti (309 aa);
NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA
dehydrogenase from Pseudomonas aeruginosa (509 aa);
P45856|HBD_BACSU probable 3-hydroxybutyryl-CoA
dehydrogenase from Bacillus subtilis (287 aa), FASTA
scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa
overlap); etc. Could belong to the 3-hydroxyacyl-CoA
dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv1715"
/db_xref="EnsemblGenomes-Tr:CCP44481"
/db_xref="GOA:L7N688"
/db_xref="InterPro:IPR006108"
/db_xref="InterPro:IPR006176"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR022694"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:L7N688"
/protein_id="CCP44481.1"
/translation="MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILH
AAAVEAARVAGAGRGSVAAAADLAAAIPDADLVIEAVVENLAVKQELFERLATLAPDA
VLATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVAL
LTQVGKLPVRVGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLA
TLGPLENADYIGLDLTLAIHDAVIPSLNHDPHPSPLLRELVAAGQLGARTGHGFLDWP
AGAREATTARLAQHIAAQLQANEKGRGT"
gene 1943576..1944406
/locus_tag="Rv1716"
CDS 1943576..1944406
/codon_start=1
/transl_table=11
/locus_tag="Rv1716"
/product="Conserved hypothetical protein"
/note="Rv1716, (MTV048.03,MTCY04C12.01), len: 276 aa.
Conserved hypothetical protein, shows high similarity with
AF1200|O29068|AE001021_11A conserved protein of
Archaeoglobus fulgidus, gp fulgidus section 7 (278
aa),FASTA scores: E(): 0, (61.8% identity in 251 a a
overlap); also weak similarity to several polyketide
cyclases e.g. O68500|AF048833|DPSY from Streptomyces
peucetius (272 aa),FASTA scores: opt: 194, E(): 1.7e-05,
(29.6% identity in 223 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1716"
/db_xref="EnsemblGenomes-Tr:CCP44482"
/db_xref="GOA:O53929"
/db_xref="InterPro:IPR007325"
/db_xref="InterPro:IPR037175"
/db_xref="UniProtKB/TrEMBL:O53929"
/protein_id="CCP44482.1"
/translation="MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGM
AKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMV
TAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVG
TDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILS
QGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV
"
gene 1944406..1944756
/locus_tag="Rv1717"
CDS 1944406..1944756
/codon_start=1
/transl_table=11
/locus_tag="Rv1717"
/product="Conserved hypothetical protein"
/note="Rv1717, (MTCY04C12.02), len: 116 aa. Conserved
hypothetical protein, similar to O29060|AF1208|AE001021
Hypothetical protein from Arecheoglobus fulgidus (114
aa),FASTA scores: opt: 254, E(): 3.3e-09, (37.7% identity
in 114 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1717"
/db_xref="EnsemblGenomes-Tr:CCP44483"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR013096"
/db_xref="InterPro:IPR014710"
/db_xref="UniProtKB/TrEMBL:O86372"
/protein_id="CCP44483.1"
/translation="MKLTRASQAPRYVAPAHHEVSTMRLQGREAGRTERFWVGLSVYR
PGGTAEPAPTREETVYVVLDGELVVTVDGAETVLGWLDSVHLAKGELRSIHNRTDRQA
LLLVTVAHPVAEVA"
repeat_region 1944756..1944808
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 1944809..1945627
/locus_tag="Rv1718"
CDS 1944809..1945627
/codon_start=1
/transl_table=11
/locus_tag="Rv1718"
/product="Conserved hypothetical protein"
/note="Rv1718, (MTCY04C12.03), len: 272 aa. Conserved
hypothetical protein, similar to O29058|AF1210|AE001021
Hypothetical protein from Archeoglobus (313 aa), FASTA
scores: opt: 301, E(): 8e-23, (31.6% identity in 301 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1718"
/db_xref="EnsemblGenomes-Tr:CCP44484"
/db_xref="GOA:P71976"
/db_xref="InterPro:IPR008567"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:P71976"
/protein_id="CCP44484.1"
/translation="MSIVITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVA
HIHLRDENERPTADPNIARRAMDLIGERCPILIQLSTGVGLTVPFEQREQLVELRPRM
ATLNPCSMSFGAGEFRNPPQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAEDLL
AEPLQFSIVLGVRGGMAATADNLLTMVRRLPPGAIWQVIAIGKANMELTAMGLALGGN
ARVGLEDTLYLRKGELAPSNLALVSRTIRLAEALDLPIASVEEAEAALQLPGTS"
gene 1945641..1946420
/locus_tag="Rv1719"
CDS 1945641..1946420
/codon_start=1
/transl_table=11
/locus_tag="Rv1719"
/product="Probable transcriptional regulatory protein"
/note="Rv1719, (MTCY04C12.04), len: 259 aa. Probable
transcriptional regulatory protein, similar to
YIAJ_ECOLI|P37671 hypothetical transcriptional regulator
from Escherichia coli (282 aa), FASTA scores: opt:
353,E(): 3.2e-15, (31.1% identity in 235 aa overlap).
Similar to Mycobacterium tuberculosis hypothetical
IclR-family transcriptional regulators Rv2989, Rv1773c.
Helix-turn-helix motif from aa 34-55 (+6.94 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1719"
/db_xref="EnsemblGenomes-Tr:CCP44485"
/db_xref="GOA:P71977"
/db_xref="InterPro:IPR005471"
/db_xref="InterPro:IPR012318"
/db_xref="InterPro:IPR014757"
/db_xref="InterPro:IPR029016"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P71977"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44485.1"
/translation="MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQAEIGERVGM
ARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVRLGVVTEMHPFLTELSRE
LDETVDLSILDGDRADVVDQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPERQA
RALPSRLAPLTANTITDRAALRDELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVEL
VAVSVPVPAQRFYGREAELAGALLAWVSKVDAWFNGTEDRK"
gene 1946613..1946686
/gene="proT"
tRNA 1946613..1946686
/gene="proT"
/product="tRNA-Pro"
/anticodon=(pos:1946647..1946649,aa:Pro,seq:ggg)
/note="codon recognized: CCC; proT, tRNA-Pro, anticodon
ggg, length = 74"
gene complement(1947030..1947419)
/gene="vapC12"
/locus_tag="Rv1720c"
CDS complement(1947030..1947419)
/codon_start=1
/transl_table=11
/gene="vapC12"
/locus_tag="Rv1720c"
/product="Possible toxin VapC12"
/note="Rv1720c, (MTCY04C12.05c), len: 129 aa. Possible
vapC12, toxin, part of toxin-antitoxin (TA) operon with
Rv1721c, contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to other Mycobacterium
tuberculosis hypothetical proteins e.g.
O53610|Rv0065|MTV030.08 (133 aa), FASTA scores: E():
1.5e-10, (39.1% identity in 128 aa overlap);
P71550|Rv0960|MTCY10D7.14C (129 aa) and
O06415|Rv0549c|MTCY25D10.28C (137 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1720c"
/db_xref="EnsemblGenomes-Tr:CCP44486"
/db_xref="GOA:P9WFA3"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFA3"
/protein_id="CCP44486.1"
/translation="MIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGA
IRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFTQRAYQLRSTHTVADGAYVALAE
GLGVPLITCDGRLAQSHGHNAEIELVA"
gene complement(1947416..1947643)
/gene="vapB12"
/locus_tag="Rv1721c"
CDS complement(1947416..1947643)
/codon_start=1
/transl_table=11
/gene="vapB12"
/locus_tag="Rv1721c"
/product="Possible antitoxin VapB12"
/note="Rv1721c, (MTCY04C12.06c), len: 75 aa. Possible
vapB12, antitoxin, part of toxin-antitoxin (TA) operon
with Rv1720c (See Arcus et al., 2005; Pandey and Gerdes,
2005). Similar to others from Mycobacterium tuberculosis
e.g. Rv0300|MTCY63.05|O07227 conserved hypothetical
protein (73 aa). Start changed since original submission."
/db_xref="EnsemblGenomes-Gn:Rv1721c"
/db_xref="EnsemblGenomes-Tr:CCP44487"
/db_xref="GOA:P9WJ53"
/db_xref="InterPro:IPR010985"
/db_xref="UniProtKB/Swiss-Prot:P9WJ53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44487.1"
/translation="MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEP
ALDDVLDRLAALPRRDLGASAAELVDEARSE"
gene 1947861..1949345
/locus_tag="Rv1722"
CDS 1947861..1949345
/codon_start=1
/transl_table=11
/locus_tag="Rv1722"
/product="Possible carboxylase"
/note="Rv1722, (MTCY04C12.07), len: 494 aa. Possible
carboxylases. Weak similarity to several e.g.
ACCC_BACSU|P49787 biotin carboxylase from Bacillus
subtilis (448 aa), fasta scores: opt: 171, E(): 0.00021,
(22.8% identity in 237 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1722"
/db_xref="EnsemblGenomes-Tr:CCP44488"
/db_xref="GOA:P71980"
/db_xref="InterPro:IPR011761"
/db_xref="UniProtKB/TrEMBL:P71980"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44488.1"
/translation="MIVPAREPEPQPRRVLNGLSDVRAFFHNNTVPLYFISPTPFNLL
GIYRWIRNFFYLTYYDSFEGEHSRVFVPRRRDRRDFDGMGDVCNHLLRDPETLEFIKN
RGPGGKACFVMLDEETQALARQAGLEVMHPPAELRHRLESKIVMTRLADEAGVPSVPH
VIGRVSSYDELSALAHGAGLGDDLVVEAAYGNAGSATFFVRGLRDWDQCAGGIVGQPE
IKVMKRIRNVEVCIEATVTRHGTVIGPAMTSLVGYPELTPYRGAWCGNDVWRGALPPA
QTRAAREMVAKLGDVLSREGYRGYFEVDLLHDLDADELYLGEVNPRLSGASPMTNLTT
EAYADMPLFLFHLLEYMDVDYELDIEAINSRWERGYGEDEVWGQLIMSETSPDLELFT
ATPRTGMWRLNHDGRVSFARQGNDWATMLDESEAFYMRVAAPGDLRCEGAQLGVLVTR
GHLQTDDYQLTERGRRWIDGLKAQFASTPLTPAAPIVSRLVARA"
gene 1949342..1950589
/locus_tag="Rv1723"
CDS 1949342..1950589
/codon_start=1
/transl_table=11
/locus_tag="Rv1723"
/product="Probable hydrolase"
/note="Rv1723, (MTCY04C12.08), len: 415 aa. Possible
hydrolase, similar to others e.g. NYLB_FLASP|P07061
6-aminohexanoate-dimer hydrolase from Flavobacterium sp.
(392 aa), FASTA scores: opt: 717, E(): 0, (35.1% identity
in 396 aa overlap). Also similar to M. tuberculosis
hypothetical esterases and penicillin binding proteins
e.g. Rv1923, Rv1497, Rv2463, etc"
/db_xref="EnsemblGenomes-Gn:Rv1723"
/db_xref="EnsemblGenomes-Tr:CCP44489"
/db_xref="GOA:P71981"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:P71981"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44489.1"
/translation="MSGGVPAGLALDNWLSSPYSHWAFQHVEDFMPTTVIARGTEPVV
TLPADNAPIADIGLTSTDGIATTVGAVMAATATDGWAVAHRGALVAEQYLDGLGPRTR
HLLFSVSKSLVAAVVGALHGAGAIELDAPVTAYVPALADCGYAGATVRHLLDMRSGVA
FSENYDDPAAEIHVREQVIGWAPKRGPDLPATLRDYLLTLRRKSAHGGPFEYRSCETD
VLGWICEAAAGQPMPELMSELLWSRIGAQCDATIALDVAGAAGTGIFDGGISACLTDM
IRFGSLYLRDGVSLAGQQVVPAAWIADTFDGGPDSRQAFAASPDDNPMPGGMYRNQVW
FPYPGSNVALCVGMCGQLIYVNRAAEVVAAKLSTQPHSHEPHMLDTLRAFDAVAHELS
GIRSSSTNDPQRPSPPAQEASPG"
gene complement(1950632..1951051)
/locus_tag="Rv1724c"
CDS complement(1950632..1951051)
/codon_start=1
/transl_table=11
/locus_tag="Rv1724c"
/product="Hypothetical protein"
/note="Rv1724c, (MTCY04C12.09c), len: 139 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1724c"
/db_xref="EnsemblGenomes-Tr:CCP44490"
/db_xref="UniProtKB/TrEMBL:P71982"
/protein_id="CCP44490.1"
/translation="MVGNEENELQDLRNLRRPCFSRAEAPIGVYNGEQAIIVYDLRPV
PHWPKYWIQALAKHFQRQLKPSPKIDISLLDDRIRFSVFVSTDVSAKDLCKLDDAVYN
AVRNAGRAIENEQAALDHKLAEVRKRRMDTWDESYFR"
gene complement(1951041..1951751)
/locus_tag="Rv1725c"
CDS complement(1951041..1951751)
/codon_start=1
/transl_table=11
/locus_tag="Rv1725c"
/product="Conserved hypothetical protein"
/note="Rv1725c, (MTCY04C12.10c), len: 236 aa. Conserved
hypothetical protein, similar to other hypothetical
proteins from diverse organisms e.g. P70885|U44893 ORF108
from butyrivibrio fibrisolvens, (108 aa), FASTA scores:
opt: 223, E(): 2e-09, (39.1% identity in 92 aa overlap).
Also similar to Mycobacterium tuberculosis hypothetical
transcriptional regulator, O05774|Rv3095|YU95_MYCTU (158
aa)."
/db_xref="EnsemblGenomes-Gn:Rv1725c"
/db_xref="EnsemblGenomes-Tr:CCP44491"
/db_xref="InterPro:IPR002577"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR036527"
/db_xref="UniProtKB/TrEMBL:P71983"
/protein_id="CCP44491.1"
/translation="MQPYGQYCPVARAAELLGDRWTLLIVRELLFGPLRFTEIERGLP
GISRSVLAQRLRRLQHDRIIEAVPEHTGGGYRFTVAGEELRPVLQTLGDWVSRWLMAD
PTPAECDPELLTLWISRRVNTEALPGRRVVVEFRYHGERPLWAWLVLEPGDISVCLHD
PCLPVDLTVRGHPRDLYRVYSGRSTLAAEISAERIELDGLPAMRRAFPSWMAWSPFAP
AMRQAVVSVDQMPEAHGG"
gene 1951852..1953237
/locus_tag="Rv1726"
CDS 1951852..1953237
/codon_start=1
/transl_table=11
/locus_tag="Rv1726"
/product="Probable oxidoreductase"
/note="Rv1726, (MTCY04C12.11), len: 461 aa. Probable
oxidoreductase, similar to HDNO_ARTOX|P08159
6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt:
678, E(): 0, (29.5% identity in 465 aa overlap). Also
similar to Mycobacterium tuberculosis hypothetical
dehydrogenases e.g. Rv3107c, Rv1257c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1726"
/db_xref="EnsemblGenomes-Tr:CCP44492"
/db_xref="GOA:P71984"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR012951"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016167"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:P71984"
/protein_id="CCP44492.1"
/translation="MTATLTKTLGSLDDFRGTLCVPGDPDYPRVRAIWNGQVAREPAL
IATCHDACDVRTVLRRAVDAGMVTAVRGGGHNVAGTALCDGGVVIDLSAMRAVSLDPA
TGRVRVQGGATLADLDHATVPFARVAPAGIVTTTGVGGLTLGGGVGWTTRRFGLSCDN
LVAVRLVTAAGDYLSVDDERDPELMWGLRGGGGNFGIVTEFEFATHPFGPVAVAGFVV
YRLDDGPAVLRGYRQFAAAAPEEVTTIVVLRHAPPAPWIPVDQRGKPVVMIGAVHTGS
IQTGIEALRPVKSLARPVADTVWPTPFLAHQAVLDASNPAGHRYYWKSDHLAELNDEA
IDLLVEQTAQLSSPDSLIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDD
LHRQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLKNRLDPDNV
FRNNHNIRPSA"
gene complement(1952291..1952503)
/gene="AS1726"
ncRNA complement(1952291..1952503)
/gene="AS1726"
/product="Putative small regulatory RNA"
/note="AS1726, putative small regulatory RNA (See Arnvig
and Young, 2009). Alternate 5'-ends at positions
1952400,1952375, 1952367, and 1952351."
/ncRNA_class="other"
gene 1953270..1953839
/locus_tag="Rv1727"
CDS 1953270..1953839
/codon_start=1
/transl_table=11
/locus_tag="Rv1727"
/product="Conserved hypothetical protein"
/note="Rv1727, (MTCY04C12.12), len: 189 aa. Conserved
hypothetical protein, similar to Mycobacterium
tuberculosis hypothetical proteins
P72040|Rv3773c|MTCY13D12.07C (194 aa), FASTA scores: opt:
176, E(): 2.7e-08, (31.1% identity in 180 aa overlap); and
O53801|Rv0738 (182 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1727"
/db_xref="EnsemblGenomes-Tr:CCP44493"
/db_xref="GOA:P71985"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR017520"
/db_xref="InterPro:IPR024344"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/TrEMBL:P71985"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44493.1"
/translation="MDLYSNLVEAEQRLVALVSSIEADSYSSPTPCDRWDVRALLSHA
LASIDAFAAAVDGAPGPDMAQVFSGADIVGDDPLGATQRITRRSQAAWSTVRDLNAEL
STFIGVMPAGQALAIITFSTVVHGWDLAVATGQAGELPEHLAEAAQQVAAELVPVLRP
RGLFAHDVDLAGEATPTQRLVALTGRKPR"
gene complement(1953864..1954634)
/locus_tag="Rv1728c"
CDS complement(1953864..1954634)
/codon_start=1
/transl_table=11
/locus_tag="Rv1728c"
/product="Conserved hypothetical protein"
/note="Rv1728c, (MTCY04C12.13c), len: 256 aa. Conserved
hypothetical protein, some similarity to
O07246|Rv0320|MTCY63.25 possible exported protein from
Mycobacterium tuberculosis (220 aa), FASTA scores: E():
1.3e-31, (42.3% identity in 220 aa overlap). C-terminal
region similar to Q9ZX60|AF068845|AF068845_17 segment of
gp17 of Mycobacteriophage TM4 (1229 aa), FASTA scores:
opt: 385, E(): 4.3e-17, (44.6% identity in 139 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1728c"
/db_xref="EnsemblGenomes-Tr:CCP44494"
/db_xref="GOA:P71986"
/db_xref="UniProtKB/TrEMBL:P71986"
/protein_id="CCP44494.1"
/translation="MSVNGLPGAHNAGLQPIDSKGCHTRRTRHTKVLFVSKGVLANGR
GRWLAIAASLVVSAAILYAQGAEHTCCRETPAAIPTGPDSAPANAPRIASPTEADLLA
ASAPVAAQQFQFALPAGVASEEGLQVKTIWVARAVSVLFPQITNIFGYRQDPLKWHPN
GLAIDVMIPNHHSDEGIQLGNQVAGLALANAKRWGVLHVIWRQGYYPGIGAPSWTADY
GSETLNHYDHVHIATDGGGYPTGRETYYVGSMSPTPPE"
gene complement(1954631..1955569)
/locus_tag="Rv1729c"
CDS complement(1954631..1955569)
/codon_start=1
/transl_table=11
/locus_tag="Rv1729c"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv1729c, (MTCY04C12.14c), len: 312 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), similar to many Mycobacterium
tuberculosis proteins e.g. Q50726|Rv3399|YX99_MYCTU (348
aa), FASTA scores: opt: 1019, E(): 0, (55.7% identity in
296 aa overlap); P95074|Rv0726c (367 aa), O53795|Rv0731c
(318 aa),and O53841|Rv0830 (301 aa), etc."
/db_xref="EnsemblGenomes-Gn:Rv1729c"
/db_xref="EnsemblGenomes-Tr:CCP44495"
/db_xref="GOA:P9WFH9"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44495.1"
/translation="MARTDDDNWDLTSSVGVTATIVAVGRALATKDPRGLINDPFAEP
LVRAVGLDLFTKMMDGELDMSTIADVSPAVAQAMVYGNAVRTKYFDDYLLNATAGGIR
QVAILASGLDSRAYRLPWPTRTVVYEIDQPKVMEFKTTTLADLGAEPSAIRRAVPIDL
RADWPTALQAAGFDSAAPTAWLAEGLLIYLKPQTQDRLFDNITALSAPGSMVATEFVT
GIADFSAERARTISNPFRCHGVDVDLASLVYTGPRNHVLDYLAAKGWQPEGVSLAELF
RRSGLDVRAADDDTIFISGCLTDHSSISPPTAAGWR"
gene complement(1955692..1957245)
/locus_tag="Rv1730c"
CDS complement(1955692..1957245)
/codon_start=1
/transl_table=11
/locus_tag="Rv1730c"
/product="Possible penicillin-binding protein"
/note="Rv1730c, (MTCY04C12.15c), len: 517 aa. Possible
penicillin-binding protein, similar to others e.g.
PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4)
from Nocardia lactamdurans (381 aa), FASTA scores: opt:
643,E(): 3.8e-32, (33.8% identity in 370 aa overlap); etc.
Also similar to other Mycobacterium tuberculosis
hypothetical penicillin binding proteins and esterases
e.g. Rv1923,Rv1497, etc."
/db_xref="EnsemblGenomes-Gn:Rv1730c"
/db_xref="EnsemblGenomes-Tr:CCP44496"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:P71988"
/protein_id="CCP44496.1"
/translation="MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAV
VETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPV
DGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQL
LNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIEL
VAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRS
CNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTG
MGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFA
SDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQL
AGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCS
QHGRLFRRQ"
gene 1957677..1959233
/gene="gabD2"
/gene_synonym="gabD1"
/locus_tag="Rv1731"
CDS 1957677..1959233
/codon_start=1
/transl_table=11
/gene="gabD2"
/gene_synonym="gabD1"
/locus_tag="Rv1731"
/product="Possible succinate-semialdehyde dehydrogenase
[NADP+] dependent (SSDH) GabD2"
/note="Rv1731, (MTCY04C12.16), len: 518 aa. Possible
gabD2,succinate-semialdehyde dehydrogenase [NADP+]
dependent,similar to others e.g. GABD_ECOLI|P25526
succinate-semialdehyde dehydrogenase from Escherichia coli
(482 aa), FASTA scores: opt: 870, E(): 0, (34.7% identity
in 449 aa overlap); etc. Also similar to
gabD1|Rv0234c|MTCY08D5.30c probable succinate-semialdehyde
dehydrogenase [NADP+] dependent from Mycobacterium
tuberculosis (511 aa); and other semialdehyde
dehydrogenases e.g. Rv0768|aldA (489 aa), Rv2858c|aldC
(455 aa), etc. Contains PS00216 Sugar transport proteins
signature 1, PS00687 Aldehyde dehydrogenases glutamic acid
active site. Belongs to the aldehyde dehydrogenases
family. Note that previously known as gabD1."
/db_xref="EnsemblGenomes-Gn:Rv1731"
/db_xref="EnsemblGenomes-Tr:CCP44497"
/db_xref="GOA:P9WNX7"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/Swiss-Prot:P9WNX7"
/inference="protein motif:PROSITE:PS00216"
/inference="protein motif:PROSITE:PS00687"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44497.1"
/translation="MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVG
TAADVEAAFAEARAAQTDWAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKARW
AAQEEIVDLIANANYYARVCVDLLKPRKAQPLLPGIGKTTVCYQPKGVVGVISPWNYP
MTLTVSDSVPALVAGNAVVLKPDSQTPYCALACAELLYRAGLPRALYAIVPGPGSVVG
TAITDNCDYLMFTGSSATGSRLAEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAA
TRACFSNAGQLCISIERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEA
QLKTVSGHVDDATAKGAKVIAGGKARPDIGPLFYEPTVLTNVAPEMECAANETFGPVV
SIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSGTVNVDEGYAFAWGS
LSAPMGGMGLSGVGRRHGPEGLLKYTESQTIATARVFNLDPPFGIPATVWQKSLLPIV
RTVMKLPGRR"
gene complement(1959243..1959791)
/locus_tag="Rv1732c"
CDS complement(1959243..1959791)
/codon_start=1
/transl_table=11
/locus_tag="Rv1732c"
/product="Conserved protein"
/note="Rv1732c, (MTCY04C12.17c), len: 182 aa. Conserved
protein, highly similar to hypothetical proteins from
several organisms e.g. P73178|SLL1289|D90904 from
Synechocystis (194 aa), FASTA scores: opt: 663, E():
0,(53.1% identity in 179 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1732c"
/db_xref="EnsemblGenomes-Tr:CCP44498"
/db_xref="GOA:P71990"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:P71990"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44498.1"
/translation="MAVESSMLALGTPAPSFTLPQPATGATVSLDELTGPALVVTFIC
NHCPYVQHVAAGLATLGRDLADQGVPMVGISSNDVVTYPQDGPDQMVAEARRHGWTFP
YLYDETQDVARAFSAACTPDTFVFDGQRRLVYRGQLDDSRPGNGRPVTAADVRAAVDA
LLAGRPVNPDQRPSIGCGIKWR"
gene complement(1959855..1960487)
/locus_tag="Rv1733c"
CDS complement(1959855..1960487)
/codon_start=1
/transl_table=11
/locus_tag="Rv1733c"
/product="Probable conserved transmembrane protein"
/note="Rv1733c, (MTCY04C12.18c), len: 210 aa. Probable
conserved transmembrane protein. Similar to
AL109962|SCJ1_26 hypothetical protein from Streptomyces
coelicolor (193 aa), FASTA scores: opt: 287, E():
3.8e-11,(35.2% identity in 182 aa overlap). Predicted
possible vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1733c"
/db_xref="EnsemblGenomes-Tr:CCP44499"
/db_xref="GOA:P9WLS9"
/db_xref="InterPro:IPR039708"
/db_xref="UniProtKB/Swiss-Prot:P9WLS9"
/protein_id="CCP44499.1"
/translation="MIATTRDREGATMITFRLRLPCRTILRVFSRNPLVRGTDRLEAV
VMLLAVTVSLLTIPFAAAAGTAVQDSRSHVYAHQAQTRHPATATVIDHEGVIDSNTTA
TSAPPRTKITVPARWVVNGIERSGEVNAKPGTKSGDRVGIWVDSAGQLVDEPAPPARA
IADAALAALGLWLSVAAVAGALLALTRAILIRVRNASWQHDIDSLFCTQR"
gene 1960667..1960783
/gene="MTS1338"
ncRNA 1960667..1960783
/gene="MTS1338"
/product="Putative small regulatory RNA"
/note="MTS1338, putative small regulatory RNA (See Arnvig
et al., 2011), 5'-end mapped by RLM-RACE, alternate 5'-end
at position 1960601, ~100 bp band detected by Northern
blot."
/ncRNA_class="other"
gene complement(1960774..1961016)
/locus_tag="Rv1734c"
CDS complement(1960774..1961016)
/codon_start=1
/transl_table=11
/locus_tag="Rv1734c"
/product="Conserved hypothetical protein"
/note="Rv1734c, (MTCY04C12.19c), len: 80 aa. Conserved
hypothetical protein, similar to C-terminal region
Q9Z8N2|CP0452|AE001615 Dihydrolipoamide Acetyltransferase
from Chlamydia pneumoniae (429 aa), FASTA scores: opt:
138,E(): 0.0012, (26.9% identity in 78 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1734c"
/db_xref="EnsemblGenomes-Tr:CCP44500"
/db_xref="GOA:P9WLS7"
/db_xref="InterPro:IPR001078"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WLS7"
/protein_id="CCP44500.1"
/translation="MTNVGDQGVDAVFGVIYPPQVALVSFGKPAQRVCAVDGAIHVMT
TVLATLPADHGCSDDHRGALFFLSINELTRCAAVTG"
gene complement(1961291..1961788)
/locus_tag="Rv1735c"
CDS complement(1961291..1961788)
/codon_start=1
/transl_table=11
/locus_tag="Rv1735c"
/product="Hypothetical membrane protein"
/note="Rv1735c, (MTCY04C12.20c), len: 165 aa. Hypothetical
membrane protein, similar to part of
O58614|PH0884|AP000004 Hypothetical malic acid transport
protein from Pyrococcus horikoshii (330 aa), FASTA scores:
opt: 167, E(): 0.0003,(29.2% identity in 120 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1735c"
/db_xref="EnsemblGenomes-Tr:CCP44501"
/db_xref="GOA:P9WLS5"
/db_xref="InterPro:IPR004695"
/db_xref="UniProtKB/Swiss-Prot:P9WLS5"
/protein_id="CCP44501.1"
/translation="MGATAITVLAGAHIVEMADAPMAIVTSGLVAGASVVFWAFGPWL
IPPLVAASIWKHVVHRVPLRYEATLWSVVFPLGMYGVGAYRLGLAAHLPIVESIGEFE
GWVALAVWTITFVAMLHHLAATIGRSGRSSHAIGAADDTHAIICRPPRSFDHQVRAFR
RNQPM"
gene complement(1962228..1964186)
/gene="narX"
/locus_tag="Rv1736c"
CDS complement(1962228..1964186)
/codon_start=1
/transl_table=11
/gene="narX"
/locus_tag="Rv1736c"
/product="Probable nitrate reductase NarX"
/note="Rv1736c, (MTCY04C12.21c), len: 652 aa. Probable
narX, nitrate reductase. Contains three domains:
N-terminus (250 aa) is similar to e.g. N-terminus of
NARG_ECOLI|P09152 respiratory nitrate reductase 1 alpha
chain from Escherichia coli (1246 aa), FASTA scores: E():
0, (58.6% identity in 251 aa overlap); and
Rv1161|MTCI65.28|NARG probable respiratory nitrate
reductase (alpha chain) from Mycobacterium tuberculosis
(1232 aa). Central region (260-410 aa) is similar to
Rv1163|O06561|NARJ probable respiratory nitrate reductase
(delta chain) from Mycobacterium tuberculosis (201 aa),
FASTA scores: E(): 0,(64.2% identity in 159 aa overlap).
C-terminus (420 aa-) is similar to Rv1164|O06562|NARI
probable respiratory nitrate reductase (gamma chain) from
Mycobacterium tuberculosis (246 aa), FASTA scores: E(): 0,
(68.6% identity in 239 aa overlap). Contains PS00551
Prokaryotic molybdopterin oxidoreductases signature 1."
/db_xref="EnsemblGenomes-Gn:Rv1736c"
/db_xref="EnsemblGenomes-Tr:CCP44502"
/db_xref="GOA:P9WJQ1"
/db_xref="InterPro:IPR003765"
/db_xref="InterPro:IPR003816"
/db_xref="InterPro:IPR006656"
/db_xref="InterPro:IPR006963"
/db_xref="InterPro:IPR020945"
/db_xref="InterPro:IPR023234"
/db_xref="InterPro:IPR027467"
/db_xref="InterPro:IPR036197"
/db_xref="InterPro:IPR036411"
/db_xref="UniProtKB/Swiss-Prot:P9WJQ1"
/inference="protein motif:PROSITE:PS00551"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44502.1"
/translation="MTVTPRTGSRIEELLARSGRFFIPGEISADLRTVTRRGGRDGDV
FYRDRWSHDKVVRSTHGVNCTGSCSWKIYVKDDIITWETQETDYPSVGPDRPEYEPRG
CPRGAAFSWYTYSPTRVRHPYARGVLVEMYREAKARLGDPVAAWADIQADPRRRRRYQ
RARGKGGLVRVSWAEATEMIAAAHVHTISTYGPDRVAGFSPIPAMSMVSHAAGSRFVE
LIGGVMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDVVWQCASVLLTYPNSRQLGT
AEELLAHIDGPAADLLGRTVSELRRADPLTAATRYVDTFDLRGRATLYLTYWTAGDTR
NRGREMLAFAQTYRSTDVAPPRGETPDFLPVVLEFAATVDPEAGRRLLSGYRVPIAAL
CNALTEAALPYAHTVAAVCRTGDMMGELFWTVVPYVTMTIVAVGSWWRYRYDKFGWTT
RSSQLYESRLLRIASPMFHFGILVVIVGHGIGLVIPQSWTQAAGLSEGAYHVQAVVLG
SIAGITTLAGVTLLIYRRRTRGPVFMATTVNDKVMYLVLVAAIVAGLGATALGSGVVG
EAYNYRETVSVWFRSVWVLQPRGDLMAEAPLYYQIHVLIGLALFALWPFTRLVHAFSA
PIGYLFRPYIIYRSREELVLTRPRRRGW"
gene complement(1964183..1965370)
/gene="narK2"
/locus_tag="Rv1737c"
CDS complement(1964183..1965370)
/codon_start=1
/transl_table=11
/gene="narK2"
/locus_tag="Rv1737c"
/product="Possible nitrate/nitrite transporter NarK2"
/note="Rv1737c, (MTCY04C12.22c), len: 395 aa. Possible
narK2, nitrate/nitrite-transport integral membrane protein
(see Hutter & Dick 2000), possibly member of major
facilitator superfamily (MFS), similar to
P46907|NARK_BACSU nitrite extrusion protein from Bacillus
subtilis (395 aa),FASTA scores: opt: 742, E(): 0, (33.6%
identity in 375 aa overlap); and to AL109989|SCJ12.23
hypothetical nitrate/nitrite transporter from Streptomyces
coelicolor (412 aa), FASTA scores: opt: 1181, E(): 0,
(49.4% identity in 389 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1737c"
/db_xref="EnsemblGenomes-Tr:CCP44503"
/db_xref="GOA:P9WJY7"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJY7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44503.1"
/translation="MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARDMSLSSAEAS
LLVATPILVGALGRIVTGPLTDRFGGRAMLIAVTLASILPVLAVGVAATMGSYALLVF
FGLFLGVAGTIFAVGIPFANNWYQPARRGFSTGVFGMGMVGTALSAFFTPRFVRWFGL
FTTHAIVAAALASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIV
FGGFVAFSNYLPTYITTIYGFSTVDAGARTAGFALAAVLARPVGGWLSDRIAPRHVVL
ASLAGTALLAFAAALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAASVGSVT
GIVAAAGGLGGYFPPLVMGATYDPVDNDYTVGLLLLVATALVACTYTALHAREPVSEE
ASR"
gene 1965657..1965941
/locus_tag="Rv1738"
CDS 1965657..1965941
/codon_start=1
/transl_table=11
/locus_tag="Rv1738"
/product="Conserved protein"
/note="Rv1738, (MTCY04C12.23), len: 94 aa. Conserved
protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical
10.1 kDa protein from Mycobacterium tuberculosis (93
aa),FASTA scores: opt: 319, E(): 2.6e-27, (53.9% identity
in 89 aa overlap). Predicted possible vaccine candidate
(See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1738"
/db_xref="EnsemblGenomes-Tr:CCP44504"
/db_xref="GOA:P9WLS3"
/db_xref="InterPro:IPR015057"
/db_xref="InterPro:IPR038070"
/db_xref="PDB:4WPY"
/db_xref="PDB:4WSP"
/db_xref="UniProtKB/Swiss-Prot:P9WLS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44504.1"
/translation="MCGDQSDHVLQHWTVDISIDEHEGLTRAKARLRWREKELVGVGL
ARLNPADRNVPEIGDELSVARALSDLGKRMLKVSTHDIEAVTHQPARLLY"
gene complement(1965955..1967637)
/locus_tag="Rv1739c"
CDS complement(1965955..1967637)
/codon_start=1
/transl_table=11
/locus_tag="Rv1739c"
/product="Probable sulphate-transport transmembrane
protein ABC transporter"
/note="Rv1739c, (MTCY04C12.24c, MTCY28.01), len: 560 aa.
Probable sulphate-transport transmembrane protein ABC
transporter, similar to several e.g. P53392|G607186 high
affinity sulphate transporter from Stylosanthes hamata
(662 aa), FASTA scores: opt: 382, E(): 1.6e-16, (28.0%
identity in 564 aa overlap); U59234.1|AAB88215.1 biotin
carb. from Synechococcus sp. PCC 7942 (574 aa), FASTA
scores: opt: 1838, E(): 0, (50.0% identity in 550 aa
overlap); etc. Contains PS00211 ABC transporters family
signature. Belongs to the ATP-binding transport protein
family (ABC transporters), and seems to belong to the SULP
family."
/db_xref="EnsemblGenomes-Gn:Rv1739c"
/db_xref="EnsemblGenomes-Tr:CCP44505"
/db_xref="GOA:P9WGF7"
/db_xref="InterPro:IPR001902"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR011547"
/db_xref="InterPro:IPR036513"
/db_xref="UniProtKB/Swiss-Prot:P9WGF7"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44505.1"
/translation="MIPTMTSAGWAPGVVQFREYQRRWLRGDVLAGLTVAAYLIPQAM
AYATVAGLPPAAGLWASIAPLAIYALLGSSRQLSIGPESATALMTAAVLAPMAAGDLR
RYAVLAATLGLLVGLICLLAGTARLGFLASLRSRPVLVGYMAGIALVMISSQLGTITG
TSVEGNEFFSEVHSFATSVTRVHWPTFVLAMSVLALLTMLTRWAPRAPGPIIAVLAAT
MLVAVMSLDAKGIAIVGRIPSGLPTPGVPPVSVEDLRALIIPAAGIAIVTFTDGVLTA
RAFAARRGQEVNANAELRAVGACNIAAGLTHGFPVSSSSSRTALADVVGGRTQLYSLI
ALGLVVIVMVFASGLLAMFPIAALGALVVYAALRLIDLSEFRRLARFRRSELMLALAT
TAAVLGLGVFYGVLAAVALSILELLRRVAHPHDSVLGFVPGIAGMHDIDDYPQAKRVP
GLVVYRYDAPLCFANAEDFRRRALTVVDQDPGQVEWFVLNAESNVEVDLTALDALDQL
RTELLRRGIVFAMARVKQDLRESLRAASLLDKIGEDHIFMTLPTAVQAFRRR"
gene 1967705..1967917
/gene="vapB34"
/locus_tag="Rv1740"
CDS 1967705..1967917
/codon_start=1
/transl_table=11
/gene="vapB34"
/locus_tag="Rv1740"
/product="Possible antitoxin VapB34"
/note="Rv1740, (MTCY28.02-MTCY04C12.25), len: 70 aa.
Possible vapB34, antitoxin, part of toxin-antitoxin (TA)
operon with Rv1741, see Arcus et al. 2005. Similar to
others in Mycobacterium tuberculosis e.g.
P96913|Rv0623|MTCY20H10.04 (84 aa), (73.5% identity in 68
aa overlap); P71998|Rv1740 (70 aa), and O07770|Rv0608 (81
aa)."
/db_xref="EnsemblGenomes-Gn:Rv1740"
/db_xref="EnsemblGenomes-Tr:CCP44506"
/db_xref="InterPro:IPR011660"
/db_xref="UniProtKB/Swiss-Prot:P9WJ31"
/protein_id="CCP44506.1"
/translation="MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGR
RCAALPVLDTRAADTILGYDERGLPA"
gene 1967917..1968165
/gene="vapC34"
/locus_tag="Rv1741"
CDS 1967917..1968165
/codon_start=1
/transl_table=11
/gene="vapC34"
/locus_tag="Rv1741"
/product="Possible toxin VapC34. Contains PIN domain."
/note="Rv1741, (MTCY28.03,MTCY04C12.26), len: 82 aa.
Possible vapC34, toxin, part of toxin-antitoxin (TA)
operon with Rv1740, contains PIN domain, see Arcus et al.
2005. Similar in N-terminus to others in Mycobacterium
tuberculosis e.g. P96914|Rv0624|MTCY20H10.05 (131
aa),(80.4% identity in 56 aa overlap); P71999|Rv1741 (82
aa) and O07769|Rv0609 (133 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1741"
/db_xref="EnsemblGenomes-Tr:CCP44507"
/db_xref="GOA:P9WF71"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF71"
/protein_id="CCP44507.1"
/translation="MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATV
IETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVLAG"
gene 1968173..1968910
/locus_tag="Rv1742"
CDS 1968173..1968910
/codon_start=1
/transl_table=11
/locus_tag="Rv1742"
/product="Unknown protein"
/note="Rv1742, (MTCY28.04,MTCY04C12.27), len: 245 aa.
Unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1742"
/db_xref="EnsemblGenomes-Tr:CCP44508"
/db_xref="GOA:O33271"
/db_xref="UniProtKB/TrEMBL:O33271"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44508.1"
/translation="MSALLDGVLDAHGGLQRWRAAETVHGRVRTGGLLLRTRVPGNRF
ADYRITVHVQQARTVLDPFPRDGYRGVFESGQVRIESHDGAVISSRAHPRAAFFGRSG
LRRNIRWDPLDSVYFAGYAMWNYLTTPYLLTREGVAVEEGAPWQQEGETWRRLIVSFP
PDIDTHSPRQTFYVDASGLLRRHDYVPEVVGHWARAAHYCADPVDVDGFVFPTCRWVH
PIGPGNRSLPFPTLVSILLTDIRVETD"
gene 1969004..1970704
/gene="pknE"
/locus_tag="Rv1743"
CDS 1969004..1970704
/codon_start=1
/transl_table=11
/gene="pknE"
/locus_tag="Rv1743"
/product="Probable transmembrane serine/threonine-protein
kinase E PknE (protein kinase E) (STPK E)"
/note="Rv1743, (MTCY28.05,MTCY04C12.28), len: 566 aa.
Probable pknE, transmembrane serine/threonine protein
kinase (see citation below), similar to PKN1_MYXXA|P33973
serine/threonine-protein kinase pkn1 (693 aa), fasta
scores: opt: 542, E(): 1.1e-19, (35.8% identity in 302 aa
overlap). Also highly similar to K08G_MYCTU|Q11053
probable serine/threonine-protein kinase (626 aa) (59.8%
identity in 381 aa overlap). Contains PS00107 Protein
kinases ATP-binding region signature. Contains Hank's
kinase subdomain. Belongs to the Ser/Thr family of protein
kinases."
/db_xref="EnsemblGenomes-Gn:Rv1743"
/db_xref="EnsemblGenomes-Tr:CCP44509"
/db_xref="GOA:P9WI77"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR012336"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:2H34"
/db_xref="UniProtKB/Swiss-Prot:P9WI77"
/inference="protein motif:PROSITE:PS00107"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44509.1"
/translation="MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVAL
KLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLA
AMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGI
ASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGD
QLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALA
TADQDRATDILRRSQVAKLPVPSTHPVSPGTRWPQPTPWAGGAPPWGPPSSPLPRSAR
QPWLWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGVFV
GSSVAPTTIDIFNEPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKN
YSTRAVAASYCVAGQNDPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAE
PTAISCIKSGADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG
"
gene complement(1970989..1971390)
/locus_tag="Rv1744c"
CDS complement(1970989..1971390)
/codon_start=1
/transl_table=11
/locus_tag="Rv1744c"
/product="Probable membrane protein"
/note="Rv1744c, (MTCY28.06c), len: 133 aa. Probable
membrane protein, contains four imperfect 10 aa
repeats,some similarity to Q25946 (MSA-2) (fragment) from
Plasmodium falciparum (205 aa), FASTA scores: opt: 145, E(
): 0.048, (52.4% identity in 63 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1744c"
/db_xref="EnsemblGenomes-Tr:CCP44510"
/db_xref="UniProtKB/TrEMBL:O06787"
/protein_id="CCP44510.1"
/translation="MVINRSIASIDSIAVAGSAATTGAVAVAGSVATAGSVAVAGSVA
TAGSVAIAGAAATAGSVGIIGSLLTVLCVAVRQCVACLACITCTRCVACIGCVRCTDC
VGCLWCVNCSGLRNVVGARNLRVGNLGRVSN"
gene complement(1971380..1971991)
/gene="idi"
/locus_tag="Rv1745c"
CDS complement(1971380..1971991)
/codon_start=1
/transl_table=11
/gene="idi"
/locus_tag="Rv1745c"
/product="Probable isopentenyl-diphosphate delta-isomerase
Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)"
/note="Rv1745c, (MTCY28.08c,MTCY04C12.29c), len: 203 aa.
Probable idi, isopentenyl-diphosphate
delta-isomerase,similar to Q46822|ORF_O182 from
Escherichia coli (182 aa),FASTA scores: opt: 465, E():
4.7e-25, (46.9% identity in 162 aa overlap), and to
IPPI_SCHPO|Q10132 isopentenyl-diphosphate delta-isomerase
from Schizosaccharomyces pombe (227 aa), FASTA scores:
opt: 185,E(): 5.4e-06, (30.3% identity in 152 aa overlap).
Belongs to the IPP isomerase type 1 family."
/db_xref="EnsemblGenomes-Gn:Rv1745c"
/db_xref="EnsemblGenomes-Tr:CCP44511"
/db_xref="GOA:P9WKK5"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR011876"
/db_xref="InterPro:IPR015797"
/db_xref="UniProtKB/Swiss-Prot:P9WKK5"
/protein_id="CCP44511.1"
/translation="MTRSYRPAPPIERVVLLNDRGDATGVADKATVHTGDTPLHLAFS
SYVFDLHDQLLITRRAATKRTWPAVWTNSCCGHPLPGESLPGAIRRRLAAELGLTPDR
VDLILPGFRYRAAMADGTVENEICPVYRVQVDQQPRPNSDEVDAIRWLSWEQFVRDVT
AGVIAPVSPWCRSQLGYLTKLGPCPAQWPVADDCRLPKAAHGN"
gene 1972138..1973568
/gene="pknF"
/locus_tag="Rv1746"
CDS 1972138..1973568
/codon_start=1
/transl_table=11
/gene="pknF"
/locus_tag="Rv1746"
/product="Anchored-membrane serine/threonine-protein
kinase PknF (protein kinase F) (STPK F)"
/note="Rv1746, (MTCY28.09, MTCY04C12.30), len: 476 aa.
pknF, transmembrane serine/threonine-protein kinase (see
citations below), highly similar to KY28_MYCTU|Q10697
probable serine/threonine-protein kinase from
Mycobacterium tuberculosis (589 aa), FASTA scores: opt:
870, E(): 0,(41.6% identity in 406 aa overlap). Contains
PS00108 Serine/Threonine protein kinases active-site
signature. Contains Hank's kinase subdomain. Belongs to
the Ser/Thr family of protein kinases. Experimental
studies show evidence of auto-phosphorylation. Start site
chosen by homology, may extend further upstream."
/db_xref="EnsemblGenomes-Gn:Rv1746"
/db_xref="EnsemblGenomes-Tr:CCP44512"
/db_xref="GOA:P9WI75"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="UniProtKB/Swiss-Prot:P9WI75"
/inference="protein motif:PROSITE:PS00108"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44512.1"
/translation="MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLR
ADVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLR
DRYPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADF
GIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPF
QHANPAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGH
RLGGAGDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVAVREFQRADD
ERAAQPARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALC
FPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESP
IRVCMQQTGQTRRECREEIRRSNGWP"
gene 1973630..1976227
/locus_tag="Rv1747"
CDS 1973630..1976227
/codon_start=1
/transl_table=11
/locus_tag="Rv1747"
/product="Probable conserved transmembrane ATP-binding
protein ABC transporter"
/note="Rv1747, (MTCY28.10, MTCY04C12.31), len: 865 aa.
Probable conserved transmembrane ATP-binding protein ABC
transporter (see citation below), similar to others e.g
Q55956 ABC transporter from Synechocystis sp. (790
aa),FASTA scores: opt: 738, E(): 6.3e-26, (31.6% identity
in 632 aa overlap); etc. Also similar to other M.
tuberculosis ABC-type transporters e.g.
Rv2397c|MTCY253.24, FASTA score: (35.2% identity in 213 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop), and PS00211 ABC transporters family signature.
Belongs to the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1747"
/db_xref="EnsemblGenomes-Tr:CCP44513"
/db_xref="GOA:O65934"
/db_xref="InterPro:IPR000253"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR008984"
/db_xref="InterPro:IPR013525"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:6CAH"
/db_xref="PDB:6CCD"
/db_xref="UniProtKB/Swiss-Prot:O65934"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44513.1"
/translation="MPMSQPAAPPVLTVRYEGSERTFAAGHDVVVGRDLRADVRVAHP
LISRAHLLLRFDQGRWVAIDNGSLNGLYLNNRRVPVVDIYDAQRVHIGNPDGPALDFE
VGRHRGSAGRPPQTTSIRLPNLSAGAWPTDGPPQTGTLGSGQLQQLPPATTRIPAAPP
SGPQPRYPTGGQQLWPPSGPQRAPQIYRPPTAAPPPAGARGGTEAGNLATSMMKILRP
GRLTGELPPGAVRIGRANDNDIVIPEVLASRHHATLVPTPGGTEIRDNRSINGTFVNG
ARVDAALLHDGDVVTIGNIDLVFADGTLARREENLLETRVGGLDVRGVTWTIDGDKTL
LDGISLTARPGMLTAVIGPSGAGKSTLARLVAGYTHPTDGTVTFEGHNVHAEYASLRS
RIGMVPQDDVVHGQLTVKHALMYAAELRLPPDTTKDDRTQVVARVLEELEMSKHIDTR
VDKLSGGQRKRASVALELLTGPSLLILDEPTSGLDPALDRQVMTMLRQLADAGRVVLV
VTHSLTYLDVCDQVLLLAPGGKTAFCGPPTQIGPVMGTTNWADIFSTVADDPDAAKAR
YLARTGPTPPPPPVEQPAELGDPAHTSLFRQFSTIARRQLRLIVSDRGYFVFLALLPF
IMGALSMSVPGDVGFGFPNPMGDAPNEPGQILVLLNVGAVFMGTALTIRDLIGERAIF
RREQAVGLSTTAYLIAKVCVYTVLAVVQSAIVTVIVLVGKGGPTQGAVALSKPDLELF
VDVAVTCVASAMLGLALSAIAKSNEQIMPLLVVAVMSQLVFSGGMIPVTGRVPLDQMS
WVTPARWGFAASAATVDLIKLVPGPLTPKDSHWHHTASAWWFDMAMLVALSVIYVGFV
RWKIRLKAC"
gene 1976600..1977331
/locus_tag="Rv1748"
CDS 1976600..1977331
/codon_start=1
/transl_table=11
/locus_tag="Rv1748"
/product="Unknown protein"
/note="Rv1748, (MTCY28.11, MTCY04C12.32), len: 243 aa.
Unknown protein. Possibly exported protein, hydrophobic
domain, TM helix aa 23-45."
/db_xref="EnsemblGenomes-Gn:Rv1748"
/db_xref="EnsemblGenomes-Tr:CCP44514"
/db_xref="GOA:P72005"
/db_xref="UniProtKB/TrEMBL:P72005"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44514.1"
/translation="MPGGVCSGRPWGRPWWHPGLVGLLIRLAELLVVMLPLIGVLYVG
IKALSSFTRRLGEASGDLASDSPAMPRPTTVENDAARWRAITRAVEAHERTDARWLEY
ELDAAKLLDFPVMTDMRDPLTTAFHKAKLQADFHKPLRAEDLLDDPDAAGHYLDAVRD
YVTAFDTAEAEAMRRRRTGFSREEQQRLARAQSLLRVASDAGATAQERERAYRLARTE
LDGLIVLPDRTRAGIERGIAGELDD"
gene complement(1977328..1977885)
/locus_tag="Rv1749c"
CDS complement(1977328..1977885)
/codon_start=1
/transl_table=11
/locus_tag="Rv1749c"
/product="Possible integral membrane protein"
/note="Rv1749c, (MTCY28.12c-MTCY04C12.33c), len: 185 aa.
Possible integral membrane protein, similar to
O27914|AE000940 hypothetical protein MTH1892 from
Methanobacterium thermoautotrophicum (168 aa), fasta
scores: E(): 9.3e-16, (37.4% identity in 123 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1749c"
/db_xref="EnsemblGenomes-Tr:CCP44515"
/db_xref="GOA:O65935"
/db_xref="UniProtKB/TrEMBL:O65935"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44515.1"
/translation="MLRAVNEIRQHDGTLKLGKGVGMFTIVGVIVALIGAFVQSRRHR
HRPAADIHMLWWMVLIVGVVSIIGAGYHVFDGERTAELIGYTRGDGGFQWENAMGDLA
IGVVGLMAYRFRGHFWLATIVVLTIQYVGDAAGHIYYWVVENNTNPYNIGVPLWTDIL
LPIVMWALYAWSWHSNGDAVPKGQP"
gene complement(1977969..1979567)
/gene="fadD1"
/locus_tag="Rv1750c"
CDS complement(1977969..1979567)
/codon_start=1
/transl_table=11
/gene="fadD1"
/locus_tag="Rv1750c"
/product="Possible fatty-acid-CoA ligase FadD1
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv1750c, (MTCY28.13c, MTCY04C12.34), len: 532 aa.
Possible fadD1, fatty-acid-CoA synthetase, similar in part
to others e.g. O35488|VLCS_MOUSE very-long-chain acyl-CoA
synthetase from Mus musculus (620 aa);
NP_113924.1|NM_031736 solute carrier family 27 (fatty acid
transporter) member 2 from Rattus norvegicus (620 aa);
NP_459076.1|NC_003197 crotonobetaine/carnitine-CoA ligase
from Salmonella typhimurium (517 aa); CAIC_ECOLI|P31552
probable crotonobetaine/carnitine-CoA ligase from
Escherichia coli (522 aa), FASTA scores: opt: 448, E():
1.9e-21, (25.1% identity in 502 aa overlap); etc. Also
highly similar to fadD17|Rv3506|MTV023.13 probable
fatty-acid-CoA ligase from Mycobacterium tuberculosis (502
aa); and similar to others from Mycobacterium tuberculosis
e.g. fadD6|MTCI364.18|Rv1206|O05307 probable
fatty-acid-CoA ligase (597 aa), FASTA score: (28.3%
identity in 519 aa overlap); etc. Contains PS00455
Putative AMP-binding domain signature. Belongs to the
ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv1750c"
/db_xref="EnsemblGenomes-Tr:CCP44516"
/db_xref="GOA:P72007"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR030310"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:P72007"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44516.1"
/translation="MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALI
TIADPQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRADCQI
VVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSG
TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGA
AIAPATFSATGFLDDVRRYHATYMNYVGKPLAYILATPERDDDADNPLRVAFGNEAND
KDIEEFSRRFGVQVEDGFGSTENAVIVIREPGTPPGSIGRGAHGVAVYNGETVTECAV
ARFDAHGALTNADEAIGELVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSE
GWIYLAGRTADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVL
RAGDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDEGTAVGK
ADTLWVREPRGSAYHHASGPAKAI"
gene 1979621..1981003
/locus_tag="Rv1751"
CDS 1979621..1981003
/codon_start=1
/transl_table=11
/locus_tag="Rv1751"
/product="Probable oxidoreductase"
/note="Rv1751, (MTCY28.14-MTCY04C12.35), len: 460 aa.
Probable oxidoreductase, possibly a monooxygenase or
hydroxylase, similar to MHPA_ECOLI|P77397
3-(3-hydroxy-phenyl) propionate hydroxylase (554 aa),
FASTA scores: opt: 239, E(): 2e-08, (24.6% identity in 435
aa overlap); and AJ007932|SAR7932.13 oxygenase from
Streptomyces argillaceus (436 aa), FASTA scores: opt:
587,E(): 8.6e-30, (32.3% identity in 359 aa overlap).
Contains PS00075 Dihydrofolate reductase signature. Also
similar to Mycobacterium tuberculosis hypothetical
oxidoreductases Rv1260 and Rv0575c."
/db_xref="EnsemblGenomes-Gn:Rv1751"
/db_xref="EnsemblGenomes-Tr:CCP44517"
/db_xref="GOA:O65936"
/db_xref="InterPro:IPR002938"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O65936"
/inference="protein motif:PROSITE:PS00075"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44517.1"
/translation="MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPY
ARALMGETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTTMR
LLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVAMVPQWDLLNLL
AEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEGPGELRAELTVACDGRWSIAR
HEAGLKAREFPVNFDVWWFKLPREGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPK
GTDAQLRERGIEEFRRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLC
IGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAVT
QAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGVRPEHAPAFA
RRGPGNRKGP"
gene 1981130..1981579
/locus_tag="Rv1752"
CDS 1981130..1981579
/codon_start=1
/transl_table=11
/locus_tag="Rv1752"
/product="Conserved hypothetical protein"
/note="Rv1752, (MTCY28.15), len: 149 aa. Conserved
hypothetical protein, similar to C-terminal half of
Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase from
Canis familiaris (335 aa), FASTA score, opt: 168, E():
0.00015,(31.3% identity in 112 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1752"
/db_xref="EnsemblGenomes-Tr:CCP44518"
/db_xref="UniProtKB/TrEMBL:O06789"
/protein_id="CCP44518.1"
/translation="MDAGCYAVHMAHTFGGATPEVVSAQAKLRDPAVDRAMTAELKFP
GGHTGGIRCSMRSSDLLNVSARVVGDRGELRVLNPVVPQLFHRLPPLACVSARRFRCR
SAARASGQDDAQGRGREHERDPRDLSGRRAPIAQPELNMVAASGSAA"
gene complement(1981614..1984775)
/gene="PPE24"
/locus_tag="Rv1753c"
CDS complement(1981614..1984775)
/codon_start=1
/transl_table=11
/gene="PPE24"
/locus_tag="Rv1753c"
/product="PPE family protein PPE24"
/note="Rv1753c, (MTCY28.16c), len: 1053 aa. PPE24, Member
of the Mycobacterium tuberculosis PPE family of
Gly-,Asn-rich proteins, similar to many e.g.
YF48_MYCTU|Q10778 hypothetical protein cy48.17 (678 aa),
FASTA scores: opt: 1360, E(): 0, (48.9% identity in 550 aa
overlap). Note that the Gly-, Asn-rich sequence is
interrupted by six near-perfect 26 aa repeats, a unique
region, and another,more degenerate region of five 25 aa
repeats before resuming at the C-terminus. The end of the
first Gly-, Asn-rich region and the start of the first set
of repeats shows some similarity to Q50577|AT10S from
Mycobacterium tuberculosis (170 aa) (40.2% identity in 189
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1753c"
/db_xref="EnsemblGenomes-Tr:CCP44519"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44519.1"
/translation="MNFSVLPPEINSALIFAGAGPEPMAAAATAWDGLAMELASAAAS
FGSVTSGLVGGAWQGASSSAMAAAAAPYAAWLAAAAVQAEQTAAQAAAMIAEFEAVKT
AVVQPMLVAANRADLVSLVMSNLFGQNAPAIAAIEATYEQMWAADVSAMSAYHAGASA
IASALSPFSKPLQNLAGLPAWLASGAPAAAMTAAAGIPALAGGPTAINLGIANVGGGN
VGNANNGLANIGNANLGNYNFGSGNFGNSNIGSASLGNNNIGFGNLGSNNVGVGNLGN
LNTGFANTGLGNFGFGNTGNNNIGIGLTGNNQIGIGGLNSGTGNFGLFNSGSGNVGFF
NSGNGNFGIGNSGNFNTGGWNSGHGNTGFFNAGSFNTGMLDVGNANTGSLNTGSYNMG
DFNPGSSNTGTFNTGNANTGFLNAGNINTGVFNIGHMNNGLFNTGDMNNGVFYRGVGQ
GSLQFSITTPDLTLPPLQIPGISVPAFSLPAITLPSLNIPAATTPANITVGAFSLPGL
TLPSLNIPAATTPANITVGAFSLPGLTLPSLNIPAATTPANITVGAFSLPGLTLPSLN
IPAATTPANITVGAFSLPGLTLPSLNIPAATTPANITVGAFSLPGLTLPSLNIPAATT
PANITVSGFQLPPLSIPSVAIPPVTVPPITVGAFNLPPLQIPEVTIPQLTIPAGITIG
GFSLPAIHTQPITVGQIGVGQFGLPSIGWDVFLSTPRITVPAFGIPFTLQFQTNVPAL
QPPGGGLSTFTNGALIFGEFDLPQLVVHPYTLTGPIVIGSFFLPAFNIPGIDVPAINV
DGFTLPQITTPAITTPEFAIPPIGVGGFTLPQITTQEIITPELTINSIGVGGFTLPQI
TTPPITTPPLTIDPINLTGFTLPQITTPPITTPPLTIDPINLTGFTLPQITTPPITTP
PLTIEPIGVGGFTTPPLTVPGIHLPSTTIGAFAIPGGPGYFNSSTAPSSGFFNSGAGG
NSGFGNNGSGLSGWFNTNPAGLLGGSGYQNFGGLSSGFSNLGSGVSGFANRGILPFSV
ASVVSGFANIGTNLAGFFQGTTS"
repeat_region complement(1982887..1982964)
/gene="PPE24"
/locus_tag="Rv1753c"
/note="78 bp imperfect direct repeat 6,
CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC
ACACCCGCCAACATCACCGT"
repeat_region complement(1982965..1983042)
/gene="PPE24"
/locus_tag="Rv1753c"
/note="78 bp imperfect direct repeat 5,
CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC
ACACCAGCCAACATCACCGT"
repeat_region complement(1983043..1983120)
/gene="PPE24"
/locus_tag="Rv1753c"
/note="78 bp imperfect direct repeat 4,
CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC
ACACCAGCCAACATCACCGT"
repeat_region complement(1983121..1983198)
/gene="PPE24"
/locus_tag="Rv1753c"
/note="78 bp imperfect direct repeat 3,
GGGTGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC
ACACCAGCCAACATCACCGT"
repeat_region complement(1983199..1983276)
/gene="PPE24"
/locus_tag="Rv1753c"
/note="78 bp imperfect direct repeat 2,
CGGCGCCTTCAGCCTGCCCGGGTTGACGTTGCCGTCGTTGAACATCCCGGCCGCCACC
ACACCAGCCAACATCACCGT"
repeat_region complement(1983277..1983354)
/gene="PPE24"
/locus_tag="Rv1753c"
/note="78 bp imperfect direct repeat 1,
TCCCGCCTTCAGTCTGCCGGCAATAACGCTGCCGTCGCTGAACATCCCGGCCGCCACC
ACACCGGCCAACATCACCGT"
gene complement(1984979..1986670)
/locus_tag="Rv1754c"
CDS complement(1984979..1986670)
/codon_start=1
/transl_table=11
/locus_tag="Rv1754c"
/product="Conserved protein"
/note="Rv1754c, (MTCY28.17c), len: 563 aa. Conserved
protein, has proline-rich central region. Some similarity
in central region to other Mycobacterium tuberculosis
proline-rich proteins e.g. O06555|Rv1157c|MTCI65.24c (371
aa), (32.5% identity in 191 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1754c"
/db_xref="EnsemblGenomes-Tr:CCP44520"
/db_xref="GOA:O06790"
/db_xref="InterPro:IPR025442"
/db_xref="UniProtKB/TrEMBL:O06790"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44520.1"
/translation="MYRYQVRVQQRRSEMNRWVATRSRRHTYQWITDHKSPRDHYRHI
SELRTSIATSSPGRCDMSPIPRIVSVSLAWAAAIGLMVPIGLAPPAMAAPCSGDAANA
PPPPSAIVTDPGATALGPVRPGHGPIPTGRKPRGANDRAPLPKLGPLISALLNPGARN
AAPLQQQALVPRANPGPNPAPNPPATGPQPPNATQLTPNPAPAPDPAPAAAPDPGATL
AGATTSLAEWVTGPDSPNKTLERFGISGTDLGIPWDNGDPANRQVLMIFGDTFGYCAV
DGHQWRYNTLFRSQDRDLGNGVHVTSGDASNRYSGSPVRQPGFSKQLINSIKWARDET
GIIPTAGIAVGKTQYVNFMSIRNWGRDGEWTTNYSGIAVSKDNGQTWGVFPGTIRASG
PDSGGKARFVPGNENFQMGAYLKSNDGYLYSFGTPPGRGGSAYLARVPQRFVPDLTKY
QYWNGDSNSWVPNKPDAATPVIPGPVGEMSVQYNTYLKQYLALYTNGMNDVVARTAPA
PQGPWSAEQMLVSSWQMPGGIYAPMMHPWSTGKDVYFNLSLWSAYNVMLMHTVLP"
gene complement(1986854..>1987696)
/gene="plcD"
/locus_tag="Rv1755c"
CDS complement(1986854..>1987696)
/codon_start=1
/transl_table=11
/gene="plcD"
/locus_tag="Rv1755c"
/product="Probable phospholipase C 4 (fragment) PlcD"
/note="Rv1755c, (MT1799, MTCY28.21c), len: 280 aa.
Probable plcD, phospholipase C 4 (fragment) (see citations
below),highly similar to C-terminus of other
phospholipases e.g.
CQ50771|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase
C 1 from Mycobacterium tuberculosis (512 aa), FASTA score:
(71.1% identity in 284 aa overlap); etc. Note that this
ORF has been interrupted by insertion of IS6110 element.
Belongs to the bacterial phospholipase C family."
/db_xref="EnsemblGenomes-Gn:Rv1755c"
/db_xref="EnsemblGenomes-Tr:CCP44521"
/db_xref="GOA:P9WIA9"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR007312"
/db_xref="InterPro:IPR017850"
/db_xref="UniProtKB/Swiss-Prot:P9WIA9"
/protein_id="CCP44521.1"
/translation="DAGVSWKVYRNKTLGPISSVLTYGSLVTSFKQSADPRSDLVRFG
VAPSYPASFAADVLANRLPRVSWVIPNVLESEHPAVPAAAGAFAIVNILRILLANPAV
WEKTALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLGFRV
PCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVTGDMTSTFNFAV
PPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIPYRVPDPQIMPTQETTPTRGIP
SGPC"
mobile_element complement(1987703..1989057)
/mobile_element_type="insertion sequence:IS6110-3"
/note="IS6110-3, len: 1355 nt. Insertion sequence IS6110."
repeat_region 1987703..1987730
/note="28 bp inverted repeat at the left end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC."
gene complement(1987745..>1988731)
/locus_tag="Rv1756c"
CDS complement(1987745..>1988731)
/codon_start=1
/transl_table=11
/locus_tag="Rv1756c"
/product="Putative transposase"
/note="Rv1756c, (MTCY28.22c), len: 328 aa. Putative
Transposase subunit for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv1756c and Rv1757c, the
sequence UUUUAAAG (directly upstream of Rv1756c) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (+ 34
aa)"
/db_xref="EnsemblGenomes-Gn:Rv1756c"
/db_xref="EnsemblGenomes-Tr:CCP44522"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP44522.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
gene complement(1988680..1989006)
/locus_tag="Rv1757c"
CDS complement(1988680..1989006)
/codon_start=1
/transl_table=11
/locus_tag="Rv1757c"
/product="Putative transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv1757c, (MTCY28.23c), len: 108 aa. Putative
Transposase for IS6110 (fragment), identical to many other
Mycobacterium tuberculosis IS6110 transposase subunits
e.g. Q50686|YIA4_MYCTU Insertion element IS6110
hypothetical 12.0 kDa protein (108 aa), fasta scores: E():
1.4e-43,(100.00% identity in 108 aa overlap). The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv1756c and
Rv1757c, the sequence UUUUAAAG (directly upstream of
Rv1756c) maybe responsible for such a frameshifting event
(see McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv1757c"
/db_xref="EnsemblGenomes-Tr:CCP44523"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP44523.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
repeat_region complement(1989030..1989057)
/note="28 bp inverted repeat at the right end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene 1989042..1989566
/gene="cut1"
/gene_synonym="clp5"
/gene_synonym="culp5"
/locus_tag="Rv1758"
CDS 1989042..1989566
/codon_start=1
/transl_table=11
/gene="cut1"
/gene_synonym="clp5"
/gene_synonym="culp5"
/locus_tag="Rv1758"
/product="Probable cutinase Cut1"
/note="Rv1758, (MTCY28.24), len: 174 aa. Probable
cut1,serine esterase, cutinase family, similar to
Rv2301|CUT2_MYCTU|Q50664 probable cutinase cy339.08c
precursor from Mycobacterium tuberculosis (219 aa), FASTA
scores: opt: 369, E(): 1. 1e-16, (39.1% identity in 179 aa
overlap). Also similar to Mycobacterium tuberculosis
hypothetical cutinases Rv3452, Rv1984c, Rv3451 and Rv3724.
CDS has been interrupted by IS6110 insertion element and
5'-end deleted. Belongs to the cutinase family."
/db_xref="EnsemblGenomes-Gn:Rv1758"
/db_xref="EnsemblGenomes-Tr:CCP44524"
/db_xref="GOA:O06793"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O06793"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44524.1"
/translation="MPGRFREDFIDALRSKIGEKSMGVYGVDYPATTDFPTAMAGIYD
AGTHVEQTAANCPQSKLVLGGFSQGAAVMGFVTAAAIPDGAPLDAPRPMPPEVADHVA
AVTLFGMPSVAFMHSIGAPPIVIGPLYAEKTIQLCAPGDPVCSSGGNWAAHNGYADDG
MVEQAAVFAAGRLG"
gene complement(1989833..1992577)
/gene="wag22"
/locus_tag="Rv1759c"
CDS complement(1989833..1992577)
/codon_start=1
/transl_table=11
/gene="wag22"
/locus_tag="Rv1759c"
/product="PE-PGRS family protein Wag22"
/note="Rv1759c, (MT1807, MTCY28.25c), len: 914 aa.
Wag22,antigen member (see citations below) of the
Mycobacterium tuberculosis PE family, PGRS subfamily of
gly-rich proteins, highly similar to others e.g.
MT1367|Q10637 hypothetical glycine-rich 49.6 kDa protein
from Mycobacterium tuberculosis (603 aa), FASTA scores:
opt: 2010, E(): 0, (53.0% identity in 724 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv1759c"
/db_xref="EnsemblGenomes-Tr:CCP44525"
/db_xref="GOA:P9WIG5"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIG5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44525.1"
/translation="MSFVIAVPETIAAAATDLADLGSTIAGANAAAAANTTSLLAAGA
DEISAAIAALFGAHGRAYQAASAEAAAFHGRFVQALTTGGGAYAAAEAAAVTPLLNSI
NAPVLAATGRPLIGNGANGAPGTGANGGDAGWLIGNGGAGGSGAKGANGGAGGPGGAA
GLFGNGGAGGAGGTATANNGIGGAGGAGGSAMLFGAGGAGGAGGAATSLVGGIGGTGG
TGGNAGMLAGAAGAGGAGGFSFSTAGGAGGAGGAGGLFTTGGVGGAGGQGHTGGAGGA
GGAGGLFGAGGMGGAGGFGDHGTLGTGGAGGDGGGGGLFGAGGDGGAGGSGLTTGGAA
GNGGNAGTLSLGAAGGAGGTGGAGGTVFGGGKGGAGGAGGNAGMLFGSGGGGGTGGFG
FAAGGQGGVGGSAGMLSGSGGSGGAGGSGGPAGTAAGGAGGAGGAPGLIGNGGNGGNG
GESGGTGGVGGAGGNAVLIGNGGEGGIGALAGKSGFGGFGGLLLGADGYNAPESTSPW
HNLQQDILSFINEPTEALTGRPLIGNGDSGTPGTGDDGGAGGWLFGNGGNGGAGAAGT
NGSAGGAGGAGGILFGTGGAGGAGGVGTAGAGGAGGAGGSAFLIGSGGTGGVGGAATT
TGGVGGAGGNAGLLIGAAGLGGCGGGAFTAGVTTGGAGGTGGAAGLFANGGAGGAGGT
GSTAGGAGGAGGAGGLYAHGGTGGPGGNGGSTGAGGTGGAGGPGGLYGAGGSGGAGGH
GGMAGGGGGVGGNAGSLTLNASGGAGGSGGSSLSGKAGAGGAGGSAGLFYGSGGAGGN
GGYSLNGTGGDGGTGGAGQITGLRSGFGGAGGAGGASDTGAGGNGGAGGKAGLYGNGG
DGGAGGDGATSGKGGAGGNAVVIGNGGNGGNAGKAGGTAGAGGAGGLVLGRDGQHGLT
"
gene 1993153..1994661
/locus_tag="Rv1760"
CDS 1993153..1994661
/codon_start=1
/transl_table=11
/locus_tag="Rv1760"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv1760, (MTCY28.26), len: 502 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004),
similar to several other Mycobacterium tuberculosis
proteins e.g. Q10554|Y895_MYCTU|MTCY31.23 (505 aa), FASTA
scores: opt: 692, E(): 0, (31.7% identity in 477 aa
overlap). Member of family with at least 15 other members
e.g. Rv3740c,Rv3734c, Rv1425, etc."
/db_xref="EnsemblGenomes-Gn:Rv1760"
/db_xref="EnsemblGenomes-Tr:CCP44526"
/db_xref="GOA:P9WKB9"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKB9"
/protein_id="CCP44526.1"
/translation="MPRGCAGARFACNACLNFLAGLGISEPISPGWAAMERLSGLDAF
FLYMETPSQPLNVCCVLELDTSTMPGGYTYGRFHAALEKYVKAAPEFRMKLADTELNL
DHPVWVDDDNFQIRHHLRRVAMPAPGGRRELAEICGYIAGLPLDRDRPLWEMWVIEGG
ARSDTVAVMLKVHHAVVDGVAGANLLSHLCSLQPDAPAPQPVRGTGGGNVLQIAASGL
EGFASRPVRLATVVPATVLTLVRTLLRAREGRTMAAPFSAPPTPFNGPLGRLRNIAYT
QLDMRDVKRVKDRFGVTINDVVVALCAGALRRFLLEHGVLPEAPLVATVPVSVHDKSD
RPGRNQATWMFCRVPSQISDPAQRIRTIAAGNTVAKDHAAAIGPTLLHDWIQFGGSTM
FGAAMRILPHISITHSPAYNLILSNVPGPQAQLYFLGCRMDSMFPLGPLLGNAGLNIT
VMSLNGELGVGIVSCPDLLPDLWGVADGFPEALKELLECSDDQPEGSNHQDS"
gene complement(1994671..1995054)
/locus_tag="Rv1761c"
CDS complement(1994671..1995054)
/codon_start=1
/transl_table=11
/locus_tag="Rv1761c"
/product="Possible exported protein"
/note="Rv1761c, (MTCY28.27c), len: 127 aa. Possibly
exported protein with hydrophobic stretch or TMhelix at aa
15-37."
/db_xref="EnsemblGenomes-Gn:Rv1761c"
/db_xref="EnsemblGenomes-Tr:CCP44527"
/db_xref="GOA:O06796"
/db_xref="InterPro:IPR031816"
/db_xref="PDB:2K3M"
/db_xref="UniProtKB/TrEMBL:O06796"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44527.1"
/translation="MSDFDTERVSRAVAAALVGPGGVALVVKVFAGLPGVIHTPARRG
FFRSNPERIQIGDWRYEVAHDGRLLAAHMVNGIVIAEDALIAEAVGPHLARALGQIVS
RYGATVIPNINAAIEVLGTGTDYRF"
gene complement(1995054..1995842)
/locus_tag="Rv1762c"
CDS complement(1995054..1995842)
/codon_start=1
/transl_table=11
/locus_tag="Rv1762c"
/product="Unknown protein"
/note="Rv1762c, (MTCY28.28c), len: 262 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1762c"
/db_xref="EnsemblGenomes-Tr:CCP44528"
/db_xref="GOA:O06797"
/db_xref="InterPro:IPR002765"
/db_xref="InterPro:IPR035439"
/db_xref="UniProtKB/TrEMBL:O06797"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44528.1"
/translation="MQSSSLDPVASERLSHAEKSFTSDLSINEFALLHGAGFEPIELV
MGVSVYHVGFQFSGMRQQQELGVLTEATYRARWNAMARMQAEADALKADGIVGVRLNW
RHHGEGGEHLEFMAVGTAVRYTAKPGAFRRPNGQAFSSHLSGQDMVTLLRSGFAPVAF
VMGNCVFHIAVQGFMQTLRQIGRNMEMPQWTQGNYQARELAMSRMQSEAERDGATGVV
GVHFAISNYAWGVHTVEFYTAGTAVRRTGSGETITPSFVLPMDS"
mobile_element 1996101..1997455
/mobile_element_type="insertion sequence:IS6110-4"
/note="IS6110-4, len: 1355 nt. Insertion sequence IS6110."
repeat_region 1996101..1996128
/note="28 bp inverted repeat at the left end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene 1996152..1996478
/locus_tag="Rv1763"
CDS 1996152..1996478
/codon_start=1
/transl_table=11
/locus_tag="Rv1763"
/product="Putative transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv1763, (MTCY28.29), len: 108 aa. Putative
Transposase for IS6110 (fragment), identical to many other
Mycobacterium tuberculosis IS6110 transposase subunits
e.g. Q50686|YIA4_MYCTU Insertion element IS6110
hypothetical 12.0 kDa protein (108 aa), fasta scores: E():
1.4e-43,(100.00% identity in 108 aa overlap). The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv1763 and Rv1764,
the sequence UUUUAAAG (directly upstream of Rv1764) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv1763"
/db_xref="EnsemblGenomes-Tr:CCP44529"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP44529.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <1996427..1997413
/locus_tag="Rv1764"
CDS <1996427..1997413
/codon_start=1
/transl_table=11
/locus_tag="Rv1764"
/product="Putative transposase"
/note="Rv1764, (MTCY28.30), len: 328 aa. Putative
Transposase for IS6110 insertion element. Identical to
many other M. tuberculosis IS6110 transposase subunits.
The transposase described here may be made by a frame
shifting mechanism during translation that fuses Rv1763
and Rv1764,the sequence UUUUAAAG (directly upstream of
Rv1764) maybe responsible for such a frameshifting event
(see McAdam et al., 1990). Start changed since first
submission (+ 34 aa)"
/db_xref="EnsemblGenomes-Gn:Rv1764"
/db_xref="EnsemblGenomes-Tr:CCP44530"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP44530.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
gene complement(1997418..1998515)
/locus_tag="Rv1765c"
CDS complement(1997418..1998515)
/codon_start=1
/transl_table=11
/locus_tag="Rv1765c"
/product="Conserved hypothetical protein"
/note="Rv1765c, (MTCY28.31c), len: 365 aa. Conserved
hypothetical protein, highly similar to
O53461|Rv2015c|MTV018.02c conserved hypothetical protein
(418 aa), (97.8% identity in 364 aa overlap). Blast hits
with non-is part of sequence submitted under MTU78639."
/db_xref="EnsemblGenomes-Gn:Rv1765c"
/db_xref="EnsemblGenomes-Tr:CCP44531"
/db_xref="GOA:O06798"
/db_xref="InterPro:IPR002711"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:O06798"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44531.1"
/translation="MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVA
ELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSL
DQVGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSA
DEQFSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAF
LRLVEAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEA
WFERDGQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGAT
ELANLVLVCPYHHRAHHRGLNRPGESGDSLI"
repeat_region complement(1997428..1997455)
/locus_tag="Rv1765c"
/note="28 bp inverted repeat at the right end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC"
mobile_element complement(1998584..1999813)
/mobile_element_type="insertion sequence:ISB9'"
/note="ISB9', len: 1230 nt. Insertion sequence ISB9,
nearly identical to EM_BA:MTU78639. Note that this
sequence shows several differences to EM_BA: MTU78639, and
the transposase ORFs are extensively frameshifted. Our
sequence has been checked and is thought to be correct;
the sequence in EM_BA:MTU78639 is from a different isolate
of Mycobacterium tuberculosis."
repeat_region 1998584..1998597
/note="14 bp Inverted repeat at the left end of
ISB9',ATCACCCCGCAAAG"
gene complement(1999142..1999357)
/locus_tag="Rv1765A"
CDS complement(1999142..1999357)
/codon_start=1
/transl_table=11
/locus_tag="Rv1765A"
/product="Putative transposase (fragment)"
/note="Rv1765A, len: 71 aa. Putative transposase
(fragment), similar to part of many transposase genes
including IS6110 e.g. P19774|TRA9_MYCTU putative
transposase from Mycobacterium tuberculosis (278 aa),
FASTA scores: opt: 231, E(): 4.7e-11, (45.35% identity in
75 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1765A"
/db_xref="EnsemblGenomes-Tr:CCP44532"
/db_xref="GOA:Q79FL0"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="UniProtKB/TrEMBL:Q79FL0"
/protein_id="CCP44532.1"
/translation="MWVADITFVRTWQGFCYTAFVTDVCTRKIVVWAVSATMRTEDLP
VQVFNHAVWQSNSDLSELVHHSDPGSQ"
gene 1999737..2000006
/locus_tag="Rv1766"
CDS 1999737..2000006
/codon_start=1
/transl_table=11
/locus_tag="Rv1766"
/product="Conserved protein"
/note="Rv1766, (MTCY28.32), len: 89 aa. Conserved
protein,highly similar to P54431|YRKD_BACSU Hypothetical
7.0 kDa protein in bltr-spoIIIC intergenic region from
Bacillus subtilis (63 aa), FASTA scores: opt: 151, E():
1.5e-05,(53.3% identity in 45 aa overlap). Also similar to
Q9RD62|SCF56.04C|AL133424 Hypothetical protein from
Streptomyces coelicolor (92 aa), FASTA scores: opt:
239,E(): 1.3e-11, (62.5% identity in 64 aa overlap). Also
some similarity to other Mycobacterium tuberculosis
hypothetical proteins e.g. O07434|Rv0190|MTCI28.29 (96
aa), (35.5% identity in 62 aa overlap); P71543|Rv0967 (119
aa), and P71600|Rv0030 (109 aa). Start changed since
original submission."
/db_xref="EnsemblGenomes-Gn:Rv1766"
/db_xref="EnsemblGenomes-Tr:CCP44533"
/db_xref="GOA:O06799"
/db_xref="InterPro:IPR003735"
/db_xref="InterPro:IPR038390"
/db_xref="UniProtKB/TrEMBL:O06799"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44533.1"
/translation="MIGDQDSIAAVLNRLRRAQGQLAGVISMIEQGRDCRDVVTQLAA
VSRALDRAGFKIVAAGLKECVSGATASGAAPLSAAELEKLFLALA"
repeat_region complement(1999800..1999813)
/note="14 bp Inverted repeat at the right end of
ISB9,ATCACCCCGGCAAG"
gene 2000074..2000433
/locus_tag="Rv1767"
CDS 2000074..2000433
/codon_start=1
/transl_table=11
/locus_tag="Rv1767"
/product="Conserved protein"
/note="Rv1767, (MTCY28.33), len: 119 aa. Conserved
protein,similar to Q57498|YA53_HAEIN hypothetical protein
HI1053 from Haemophilus influenzae (113 aa), FASTA scores:
opt: 233, E(): 6.4e-10, (40.0% identity in 90 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1767"
/db_xref="EnsemblGenomes-Tr:CCP44534"
/db_xref="GOA:O06800"
/db_xref="InterPro:IPR003779"
/db_xref="InterPro:IPR004675"
/db_xref="InterPro:IPR029032"
/db_xref="UniProtKB/TrEMBL:O06800"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44534.1"
/translation="MSDQPRHHQVLDDLLPQHRALRHQIPQVYQRFVALGDAALTDGA
LSRKVKELVALAIAVVQGCDGCVASHAQAAVRAGATAQEAAEAIGVTILMHGGPATIH
GARAYAAFCEFADTTPS"
gene 2000614..2002470
/gene="PE_PGRS31"
/locus_tag="Rv1768"
CDS 2000614..2002470
/codon_start=1
/transl_table=11
/gene="PE_PGRS31"
/locus_tag="Rv1768"
/product="PE-PGRS family protein PE_PGRS31"
/note="Rv1768, (MTCY28.34), len: 618 aa. PE_PGRS31, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan and Delogu,
2002), highly similar to Q50615 hypothetical 40.8 kDa
protein (498 aa),FASTA scores: opt: 1703, E(): 0, (57.4%
identity in 566 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1768"
/db_xref="EnsemblGenomes-Tr:CCP44535"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FK9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44535.1"
/translation="MSYLVVVPELVAAAATDLANIGSSISAANAAAAAPTTALVAAGG
DEVSAAIAALFGAHARAYQALSAQAAMFHEQFVRALAAGGNSYAVAEAATAQSVQQDL
LNLINAPTQALLGRPLIGNGANGLPGTGQNGGDGGILYGNGGNGGSGGVNQAGGNGGN
AGLWGNGGSGGAGGNATTAGRNGFNGGAGGSGGLLWGNGGAGGAGGNGGPAPLVGGVG
TTGGAGGNGGGAGLFYGFGGAGGNGGMGGVAPSTGPSMGILPAGGVGGPGGSGGASAL
AFGSGGVGGAGGLGGPTDGTVQGVGGFGGQGGNGGQSGLLFGNAGAGGAGAAGGAGTG
DTESFGGHGGAGGDGGAVGLIGNGGAGGTGSPGAVVGGNGGVGGLGGAGSPGGLLYGT
GGAGGNGGPGGDGGTGATVGFAGSGGFGGAGGIAQLFGTGGMGGSGGGIGAGTTTVVP
PDVAPVGGTGGNGGRAGLLLGVGGMGGNGGATSVGGTLYAAGGNGGDGGLVWGNGGTG
GSGGAGGAGSVGNGGAGGNAALLFGNGGAGGAGGAGGIGAGGAGGFGAVLFGNGGAGG
SGAPGGIGAGGNGGNALLVGNGGNGGAGTGGAAGGAGGSGGLLFGQNGMPGP"
gene 2002626..2003870
/locus_tag="Rv1769"
CDS 2002626..2003870
/codon_start=1
/transl_table=11
/locus_tag="Rv1769"
/product="Conserved protein"
/note="Rv1769, (MTCY28.35), len: 414 aa. Conserved
protein,similar to O88066|SCI35.31|AL031541 hypothetical
protein from Streptomyces coelicolor (402 aa), FASTA
scores: opt: 1341, E(): 0, (53.8% identity in 398 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1769"
/db_xref="EnsemblGenomes-Tr:CCP44536"
/db_xref="GOA:O06802"
/db_xref="InterPro:IPR001608"
/db_xref="InterPro:IPR029066"
/db_xref="UniProtKB/TrEMBL:O06802"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44536.1"
/translation="MHEVAAREQRSDGPMRLDAQGRLQRYEEAFADYDAPFAFVDLDA
MWGNADQLLARAGDKPIRVASKSLRCRPLQREILDASERFDGLLTFTLTETLWLAGQG
FSNLLLAYPPTDRAALRALGELTAKDPDGAPIVMVDSVEHLDLIERTTDKPVRLCLDF
DAGYWRAGGRIKIGSKRSPLHTPEQARALAVEIARRPALTLAALMCYEAHIAGLGDNV
AGKRVHNAIIRRMQRMSFEELRERRARAVELVREVADIKIVNAGGTGDLQLVAQEPLI
TEATAGSGFYAPTLFDSYSTFTLQPAAMFALPVCRRPGAKTVTALGGGYLASGVGAKD
RMPTPYLPVGLKLNALEGTGEVQTPLSGDAARRLKLGDKVYFRHTKAGELCERFDHLH
LVRGAEVVDTVPTYRGEGRTFL"
gene 2003878..2005164
/locus_tag="Rv1770"
CDS 2003878..2005164
/codon_start=1
/transl_table=11
/locus_tag="Rv1770"
/product="Conserved protein"
/note="Rv1770, (MTCY28.36), len: 428 aa. Conserved
protein,highly similar in N-terminus to Q49882
Hypothetical protein from Mycobacterium leprae from cosmid
L247 (83 aa), FASTA scores: opt: 301, E(): 1e-12, (56.5%
identity in 85 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1770"
/db_xref="EnsemblGenomes-Tr:CCP44537"
/db_xref="GOA:O06803"
/db_xref="InterPro:IPR007484"
/db_xref="UniProtKB/TrEMBL:O06803"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44537.1"
/translation="MDEAHPAHPADAGRPGGPIQGARRGAAMTPITALPTELAAMREV
VETLAPIERAAGEPGEHKAAEWIVERLRTAGAQDARIEEEQYLDGYPRLHLKLSVIGV
AAGVAGLLSRRLRIPAALAGVGAGLAIADDCANGPRIVRKRTETPRTTWNAVAEAGDP
AGQLTVVVCAHHDAAHSGKFFEAHIEEVMVELFPGIVERIDTQLPNWWGPILAPALAG
VGALRGSRPMMIAGTVGSALAAALFADIARSPVVPGANDNLSAVALLVALAERLRERP
VKGVRVLLVSLGAEETLQGGIYGFLARHKPELDRDRTYFLNFDTIGSPELIMLEGEGP
TVMEDYFYRPFRDLVIRAAERADAPLRRGIRSRNSTDAVLMSRAGYPTACFVSINRHK
SVANYHLMSDTPENLCYETVSHAVTVAESVIRELAR"
gene 2005161..2006447
/locus_tag="Rv1771"
CDS 2005161..2006447
/codon_start=1
/transl_table=11
/locus_tag="Rv1771"
/product="L-gulono-1,4-lactone dehydrogenase"
/note="Rv1771, (MTCY28.37), len: 428 aa.
L-gulono-1,4-lactone dehydrogenase (See Wolucka and
Communi, 2006), similar to e.g. GGLO_RAT|P10867
l-gulonolactone oxidase (439 aa), FASTA scores: opt:
862,E(): 0, (34.1% identity in 434 aa overlap). Also shows
slight similarity to Mycobacterium tuberculosis
oxidoreductase Rv1726|MTCY04C12.11 (22.9% identity in 441
aa overlap) and others e.g. Rv3107c, Rv1257c, Rv2251, etc.
Contains PS00862 Oxygen oxidoreductases covalent
FAD-binding site. Alternative nucleotide at position
2006032 (a->G; Q291R) has been observed."
/db_xref="EnsemblGenomes-Gn:Rv1771"
/db_xref="EnsemblGenomes-Tr:CCP44538"
/db_xref="GOA:P9WIT3"
/db_xref="InterPro:IPR006093"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR007173"
/db_xref="InterPro:IPR010031"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016167"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR016171"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/Swiss-Prot:P9WIT3"
/inference="protein motif:PROSITE:PS00862"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44538.1"
/translation="MSPIWSNWPGEQVCAPSAIVRPTSEAELADVIAQAAKRGERVRA
VGSGHSFTDIACTDGVMIDMTGLQRVLDVDQPTGLVTVEGGAKLRALGPQLAQRRLGL
ENQGDVDPQSITGATATATHGTGVRFQNLSARIVSLRLVTAGGEVLSLSEGDDYLAAR
VSLGALGVISQVTLQTVPLFTLHRHDQRRSLAQTLERLDEFVDGNDHFEFFVFPYADK
ALTRTMHRSDEQPKPTPGWQRMVGENFENGGLSLICQTGRRFPSVAPRLNRLMTNMMS
SSTVQDRAYKVFATQRKVRFTEMEYAIPRENGREALQRVIDLVRRRSLPIMFPIEVRF
SAPDDSFLSTAYGRDTCYIAVHQYAGMEFESYFRAVEEIMDDYAGRPHWGKRHYQTAA
TLRERYPQWDRFAAVRDRLDPDRVFLNDYTRRVLGP"
gene 2006636..2006947
/locus_tag="Rv1772"
CDS 2006636..2006947
/codon_start=1
/transl_table=11
/locus_tag="Rv1772"
/product="Hypothetical protein"
/note="Rv1772, (MTCY28.38), len: 103 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1772"
/db_xref="EnsemblGenomes-Tr:CCP44539"
/db_xref="GOA:O06805"
/db_xref="InterPro:IPR005561"
/db_xref="InterPro:IPR024189"
/db_xref="UniProtKB/TrEMBL:O06805"
/protein_id="CCP44539.1"
/translation="MGSTGGSQPMTANRGPAAISSGSNSGRVLDTARGILIALRRCPA
ETAFDELHNAAQRHRLPVFEIAWALVHLAVEGSTPCRSFVDAQSAARREWGQLFAHAA
A"
gene complement(2007020..2007766)
/locus_tag="Rv1773c"
CDS complement(2007020..2007766)
/codon_start=1
/transl_table=11
/locus_tag="Rv1773c"
/product="Probable transcriptional regulatory protein"
/note="Rv1773c, (MTCY28.39), len: 248 aa. Probable
transcriptional regulator belonging to IclR family,
similar to ICLR_ECOLI|P16528 acetate operon repressor from
Escherichia coli (274 aa), FASTA scores: opt: 261, E():
3.3e-10, (26.9% identity in 249 aa overlap). Also similar
to Mycobacterium tuberculosis protein Rv1719|MTCY04C12.04
(40.2% identity in 244 aa overlap); and Rv2989. Start site
chosen by homology, but may extend further upstream.
Contains possible helix-turn-helix motif at aa 37-58
(+3.24 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1773c"
/db_xref="EnsemblGenomes-Tr:CCP44540"
/db_xref="GOA:O06806"
/db_xref="InterPro:IPR005471"
/db_xref="InterPro:IPR014757"
/db_xref="InterPro:IPR029016"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O06806"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44540.1"
/translation="MPPTEGKSTTNRDEGIQVLRRAVAALDEIAAEPGHLRLVDLCER
LGLAKSTTRRLLVGLVEVGLVSVDSHGRFALGERLLGFGSVTGAHIAAAFRPTVERVA
RATDGETVDLSVLRGQRMWFVDQIESSYRLRAVSAVGLRFPLNGTANGKAALAALDDA
DAEAALCRLDPMVAEGLRREIVEIRRTGIAFDRNEHTPGISAAAIARRALGDNVIAIS
VPAPTARFLEKEQRIIAALRAAADSPDWTR"
gene 2007832..2009172
/locus_tag="Rv1774"
CDS 2007832..2009172
/codon_start=1
/transl_table=11
/locus_tag="Rv1774"
/product="Probable oxidoreductase"
/note="Rv1774, (MTCY25C11.01), len: 446 aa. Probable
oxidoreductase, similar to several e.g. HDNO_ARTOX|P08159
6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt:
417, E(): 6e-20, (28.4% identity in 462 aa overlap). Also
some similarity to Mycobacterium tuberculosis
oxidoreductase MTCY04C12.11 (24.1% identity in 444 aa
overlap). Contains PS00862 Oxygen oxidoreductases covalent
FAD-binding site."
/db_xref="EnsemblGenomes-Gn:Rv1774"
/db_xref="EnsemblGenomes-Tr:CCP44541"
/db_xref="GOA:O33177"
/db_xref="InterPro:IPR006093"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016167"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:O33177"
/inference="protein motif:PROSITE:PS00862"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44541.1"
/translation="MRALPAGRHFFRGSDGYEAARRGTVWHRRVPDRYPEVIVQAVSA
DDIVSAIRYATVNGHKVSVVSGGHSFAASHLRDGAVLLDVSRIDHASIDADKGRAVVG
PGKGGSVLMAELEAQGLFFPGGHCRGVCLGGYLLQGGYGWNSRIYGPACESVIGLDVI
TADGAQIHCDADNHADLYWAARGAGPGFFGVVTSFYLKLYPRPATCGTSVYVYPFDLA
DEVFTWARAVSAEVDPRVELQALASRGEPSMGIDVPVISLASPAFADSPEEAEQALAL
FGTCPVVEQALVKVPYMPTDLPAWYDVAMTHYLSDHHYAVDNMWTSASAEDLLPGIRS
ILDTLPPHPAHFLWLNWGPCPPRQDMAYSIEADIYLALYGSWKDPADEAKYADWARSH
MAAMSHLAVGIQLADENLGARPARFASDAAMAKLDRVRAEYDPDGLFNSWMGRI"
gene 2009172..2009990
/locus_tag="Rv1775"
CDS 2009172..2009990
/codon_start=1
/transl_table=11
/locus_tag="Rv1775"
/product="Conserved hypothetical protein"
/note="Rv1775, (MTCY25C11.02), unknown, len: 272 aa.
Conserved hypothetical protein, similar to O28806|AF1466
conserved hypothetical protein from Archaeoglobus fulgidus
(255 aa), FASTA scores: opt: 364, E(): 1e-17, (29.2%
identity in 267 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1775"
/db_xref="EnsemblGenomes-Tr:CCP44542"
/db_xref="InterPro:IPR041526"
/db_xref="UniProtKB/TrEMBL:O33178"
/protein_id="CCP44542.1"
/translation="MASDLYLGYRNDDADTPFGKFFKPEMAPLPQHVVVALQHGPQAG
MALLAFDDAASIVDEGYQQTENGYGILGDGSMQVSVRTDMPGVTPAMWAWWFGWHGSD
TRRYKLWHPRAHLSARWKDGDQDSGAGRRGAQRYVGRWSMISEYIGSTKLGAAIQFVE
PAAMGLPDDSDDTVSICARLGSADAPVDAGWFVHQVRSTPGGSEMRSRFWMGGPHIAV
RKAPEVASKAVRPIASKLIGVSESTARNLLVYCAQEMNHLAGFLADLWESFGDE"
gene complement(2009995..2010555)
/locus_tag="Rv1776c"
CDS complement(2009995..2010555)
/codon_start=1
/transl_table=11
/locus_tag="Rv1776c"
/product="Possible transcriptional regulatory protein"
/note="Rv1776c, (MTCY25C11.03c), len: 186 aa. Possible
regulatory protein, some similarity to Mycobacterium
tuberculosis Rv1255c|Q11063 hypothetical transcriptional
regulator (202 aa), FASTA scores: opt: 270, E():
9.7e-09,(28.3% identity in 191 aa overlap). Contains
possible helix-turn-helix motif at aa 37-58 (+3.49 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1776c"
/db_xref="EnsemblGenomes-Tr:CCP44543"
/db_xref="GOA:O33179"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:O33179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44543.1"
/translation="MPGNDWIVGGNRRTIAAERIYAAATDLITRYGLNALDIDKLARE
VHCSRATIYRRAGGKAQIRDVVLTRAAARIADGVRSDVETLRGRERVVAAILLSLQRI
RSDPLGKLMFGSIHGGAGELAWLTESPLLADFATELTGIAGGDPQGAKWVVRVVLSLM
YWPAENDEAERRLVEKYVAPAFAEQS"
gene 2010656..2011960
/gene="cyp144"
/locus_tag="Rv1777"
CDS 2010656..2011960
/codon_start=1
/transl_table=11
/gene="cyp144"
/locus_tag="Rv1777"
/product="Probable cytochrome P450 144 Cyp144"
/note="Rv1777, (MT1827, MTCY25C11.04), len: 434 aa.
Probable cyp144, cytochrome p450, similar to
CPXM_BACME|Q06069 cytochrome p450 (meg) (410 aa), FASTA
scores: opt: 435 E(): 2.3e-16, (28.8% identity in 372 aa
overlap). Also similar to several other Mycobacterium
tuberculosis p450 genes including Rv0766c, Rv2266, etc.
Contains PS00086 Cytochrome P450 cysteine heme-iron ligand
signature. Belongs to the cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv1777"
/db_xref="EnsemblGenomes-Tr:CCP44544"
/db_xref="GOA:P9WPL1"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:5HDI"
/db_xref="UniProtKB/Swiss-Prot:P9WPL1"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP44544.1"
/translation="MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAE
SVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAE
GTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWV
DGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLV
AAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGG
ESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTL
DGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALAR
LEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ"
gene complement(2012081..2012530)
/locus_tag="Rv1778c"
CDS complement(2012081..2012530)
/codon_start=1
/transl_table=11
/locus_tag="Rv1778c"
/product="Unknown protein"
/note="Rv1778c, (MTCY25C11.05c), len: 149 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1778c"
/db_xref="EnsemblGenomes-Tr:CCP44545"
/db_xref="UniProtKB/TrEMBL:O33181"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44545.1"
/translation="MRVSLFLSDAAQADAQSGKVHALGLGWRQCQTPTPPFALVLFLD
IDWDETNKQHQLKCQLLTADGDPVVVPGPHGPQRILFEAAAEAGRAPGAIHGTSVRMP
LTLNIPAGIPLEPGIYEWRVEVEGYERATAVEAFIVAGGGHPPASCG"
gene complement(2012686..2014479)
/locus_tag="Rv1779c"
CDS complement(2012686..2014479)
/codon_start=1
/transl_table=11
/locus_tag="Rv1779c"
/product="Possible integral membrane protein"
/note="Rv1779c, (MTV049.01c), len: 597 aa. Possible
integral membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1779c"
/db_xref="EnsemblGenomes-Tr:CCP44546"
/db_xref="GOA:O53930"
/db_xref="InterPro:IPR025519"
/db_xref="UniProtKB/TrEMBL:O53930"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44546.1"
/translation="MCAHEYAEQRSAVSGIEGLLTWLGGGHWRELGERHERSTHAVAG
VIVAVGAALAGLLASLAVSEAAQGPISSPIGAASLALVLGLLVGAVTRGTASGPARGR
AGVTGRASVAVAVGFVVGELAALVMFSGAIDRRLDEQAMHSADATPAAVQASASLQQA
RNARTALDSAVERARGRLDDALVVARCEYHPTPACPQTRITGVPGRGPETRTANQLLA
DAQRELDNALAARDHQAPALDAKMAHDEQALAEVRQAVVADAGRGLGSRWVAMNDLTL
ASAGALTARMLAIAFFALLYLLPLILRLWRGDTTHDRHAAARAERERAELEADTAIAI
KRAEVRRAAEIMWAEHQLTQTRLAIEAQAEIDREQQRRRVVEALEGPVRASSERTLQP
VEDEVYLPIAAETEAASRTVAQLPAGAAHHRPGIAKNLPAQVQPEGAVEPREKRATPV
IRSIPDATKAAARWIRPLVPPFVARMLDNTTAPLRTARQVFEEVEEIAFSFKRTHKVT
VNAEGSDPNDQPPLESHSPAAPAESNPIASSDSARRSRLATNDDHPPLAQVPPRDLAS
LSVGSTGELTQREGPHELRSPDGPRQLPPPR"
gene 2014699..2015262
/locus_tag="Rv1780"
CDS 2014699..2015262
/codon_start=1
/transl_table=11
/locus_tag="Rv1780"
/product="Conserved protein"
/note="Rv1780, (MTV049.02), len: 187 aa. Conserved
protein,equivalent to Q49881|ML1380|U00021_2 cosmid L247
from Mycobacterium leprae (187 aa), FASTA scores: opt:
1000,E(): 0, (82.4% identity in 187 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1780"
/db_xref="EnsemblGenomes-Tr:CCP44547"
/db_xref="GOA:O53931"
/db_xref="UniProtKB/TrEMBL:O53931"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44547.1"
/translation="MQNHDYVTYEEFGRRFFEVAVTPDRVAAAFADIAGSEFAMEPIS
QGPGGIAKVSANVKIREPRVTRKLGDLITFVIHIPLSIDLLLDLRLDKQRFMVAGDIA
LRATARAAEPLLLIVDVAKPRPSDITVNVSSKSIRGEVLRILAGVDGEIRRFIAQYVS
AEIDSPKSQAAQVINVAEQLDSTWSGP"
gene complement(2015302..2017476)
/gene="malQ"
/locus_tag="Rv1781c"
CDS complement(2015302..2017476)
/codon_start=1
/transl_table=11
/gene="malQ"
/locus_tag="Rv1781c"
/product="Probable 4-alpha-glucanotransferase MalQ
(amylomaltase) (disproportionating enzyme) (D-enzyme)"
/note="Rv1781c, (MTV049.03c), len: 724 aa. Probable
malQ,4-alpha-glucanotransferase, similar to many, e.g.
P15977|MALQ_ECOLI 4-alpha-glucanotransferase (694
aa),FASTA scores: opt: 964, E(): 0, (31.8% identity in 694
aa overlap). Belongs to the disproportionating enzyme
family."
/db_xref="EnsemblGenomes-Gn:Rv1781c"
/db_xref="EnsemblGenomes-Tr:CCP44548"
/db_xref="GOA:P9WK23"
/db_xref="InterPro:IPR003385"
/db_xref="InterPro:IPR017853"
/db_xref="UniProtKB/Swiss-Prot:P9WK23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44548.1"
/translation="MTELAPSLVELARRFGIATEYTDWTGRQVLVSEATLVAALAALG
VPAQTEQQRNDALAAQLRSYWARPLPATIVMRAGEQTQFRVHVTDGAPADVWLQLEDG
TTRAEVVQVDNFTPPFDLDGRWIGEASFVLPADLPLGYHRVNLRSGDSQASAAVVVTP
DWLGLPDKLAGRRAWGLAVQLYSVRSRQSWGIGDLTDLANLALWSASAHGAGYVLVNP
LHAATLPGPAGRSKPIEPSPYLPTSRRFVNPLYLRVEAIPELVDLPKRGRVQRLRTNV
QQHADQLDTIDRDSAWAAKRAALKLVHRVPRSAGRELAYAAFRTREGRALDDFATWCA
LAETYGDDWHRWPKSLRHPDASGVADFVDKHADAVDFHRWLQWQLDEQLASAQSQALR
AGMSLGIMADLAVGVHPNGADAWALQDVLAQGVTAGAPPDEFNQLGQDWSQPPWRPDR
LAEQEYRPFRALIQAALRHAGAVRIDHIIGLFRLWWIPDGAPPTQGTYVRYDHDAMIG
IVALEAHRAGAVVVGEDLGTVEPWVRDYLLLRGLLGTSILWFEQDRDCGPAGTPLPAE
RWREYCLSSVTTHDLPPTAGYLAGDQVRLRESLGLLTNPVEAELESARADRAAWMAEL
RRVGLLADGAEPDSEEAVLALYRYLGRTPSRLLAVALTDAVGDRRTQNQPGTTDEYPN
WRVPLTGPDGQPMLLEDIFTDRRAATLAEAVRAATTSPMSCW"
gene 2017740..2019260
/gene="eccB5"
/locus_tag="Rv1782"
CDS 2017740..2019260
/codon_start=1
/transl_table=11
/gene="eccB5"
/locus_tag="Rv1782"
/product="ESX conserved component EccB5. ESX-5 type VII
secretion system protein. Probable membrane protein."
/note="Rv1782, (MTV049.04), len: 506 aa. eccB5, esx
conserved component, ESX-5 type VII secretion system
protein, probable membrane protein, similar to four other
Mycobacterium tuberculosis hypothetical membrane proteins
e.g. O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa), FASTA
scores: opt: 1106, E(): 0, (41.2% identity in 485 aa
overlap); Rv0283, Rv3450c, and Rv3869, all located near
ESAT-6 family genes. Also similar to
O33088|MLCB628.17C|Y14967 cosmid B628 from Mycobacterium
leprae (481 aa), (32.7% identity in 486 aa overlap); and
equivalent to Q9Z5I3|MLCB596.27|AL035472 hypothetical
protein from Mycobacterium leprae (506 aa) (82.6% identity
in 506 aa overlap). Has hydrophobic stretch from aa 54-76.
A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1782"
/db_xref="EnsemblGenomes-Tr:CCP44549"
/db_xref="GOA:P9WNQ9"
/db_xref="InterPro:IPR007795"
/db_xref="InterPro:IPR042485"
/db_xref="UniProtKB/Swiss-Prot:P9WNQ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44549.1"
/translation="MAEESRGQRGSGYGLGLSTRTQVTGYQFLARRTAMALTRWRVRM
EIEPGRRQTLAVVASVSAALVICLGALLWSFISPSGQLNESPIIADRDSGALYVRVGD
RLYPALNLASARLITGRPDNPHLVRSSQIATMPRGPLVGIPGAPSSFSPKSPPASSWL
VCDTVATSSSIGSLQGVTVTVIDGTPDLTGHRQILSGSDAVVLRYGGDAWVIREGRRS
RIEPTNRAVLLPLGLTPEQVSQARPMSRALFDALPVGPELLVPEVPNAGGPATFPGAP
GPIGTVIVTPQISGPQQYSLVLGDGVQTLPPLVAQILQNAGSAGNTKPLTVEPSTLAK
MPVVNRLDLSAYPDNPLEVVDIREHPSTCWWWERTAGENRARVRVVSGPTIPVAATEM
NKVVSLVKADTSGRQADQVYFGPDHANFVAVTGNNPGAQTSESLWWVTDAGARFGVED
SKEARDALGLTLTPSLAPWVALRLLPQGPTLSRADALVEHDTLPMDMTPAELVVPK"
gene 2019257..2023432
/gene="eccC5"
/locus_tag="Rv1783"
CDS 2019257..2023432
/codon_start=1
/transl_table=11
/gene="eccC5"
/locus_tag="Rv1783"
/product="ESX conserved component EccC5. ESX-5 type VII
secretion system protein."
/note="Rv1783, (MTV049.05-MTV049.06), len: 1391 aa.
eccC5,esx conserved component, ESX-5 type VII secretion
system protein, probable membrane protein. FtsK/SpoIIIE
family protein. Similar to Rv3894c. Member of family of
Mycobacterium tuberculosis hypothetical proteins including
Rv3447c, Rv0284, Rv3870, Rv1783, Rv3871, Rv3894c, all
linked to ESAT-6 family genes. Equivalent to Mycobacterium
leprae hypothetical protein Q9Z512|MLCB596.28|AL035472
(1345 aa). Previously annotated as two separate genes
eccCa5|Rv1783 and eccCb5|Rv1784, now fused due to A:T
correction at position 2020563 resulting in *463L.
Contains two times PS00017 ATP/GTP-binding site motif A
(P-loop). Former Rv1784 - Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1783"
/db_xref="EnsemblGenomes-Tr:CCP44550"
/db_xref="GOA:P9WNA5"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR023836"
/db_xref="InterPro:IPR023837"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNA5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44550.1"
/translation="MKRGFARPTPEKPPVIKPENIVLSTPLSIPPPEGKPWWLIVVGV
VVVGLLGGMVAMVFASGSHVFGGIGSIFPLFMMVGIMMMMFRGMGGGQQQMSRPKLDA
MRAQFMLMLDMLRETAQESADSMDANYRWFHPAPNTLAAAVGSPRMWERKPDGKDLNF
GVVRVGVGMTRPEVTWGEPQNMPTDIELEPVTGKALQEFGRYQSVVYNLPKMVSLLVE
PWYALVGEREQVLGLMRAIICQLAFSHGPDHVQMIVVSSDLDQWDWVKWLPHFGDSRR
HDAAGNARMVYTSVREFAAEQAELFAGRGSFTPRHASSSAQTPTPHTVIIADVDDPQW
EYVISAEGVDGVTFFDLTGSSMWTDIPERKLQFDKTGVIEALPRDRDTWMVIDDKAWF
FALTDQVSIAEAEEFAQKLAQWRLAEAYEEIGQRVAHIGARDILSYYGIDDPGNIDFD
SLWASRTDTMGRSRLRAPFGNRSDNGELLFLDMKSLDEGGDGPHGVMSGTTGSGKSTL
VRTVIESLMLSHPPEELQFVLADLKGGSAVKPFAGVPHVSRIITDLEEDQALMERFLD
ALWGEIARRKAICDSAGVDDAKEYNSVRARMRARGQDMAPLPMLVVVIDEFYEWFRIM
PTAVDVLDSIGRQGRAYWIHLMMASQTIESRAEKLMENMGYRLVLKARTAGAAQAAGV
PNAVNLPAQAGLGYFRKSLEDIIRFQAEFLWRDYFQPGVSIDGEEAPALVHSIDYIRP
QLFTNSFTPLEVSVGGPDIEPVVAQPNGEVLESDDIEGGEDEDEEGVRTPKVGTVIID
QLRKIKFEPYRLWQPPLTQPVAIDDLVNRFLGRPWHKEYGSACNLVFPIGIIDRPYKH
DQPPWTVDTSGPGANVLILGAGGSGKTTALQTLICSAALTHTPQQVQFYCLAYSSTAL
TTVSRIPHVGEVAGPTDPYGVRRTVAELLALVRERKRSFLECGIASMEMFRRRKFGGE
AGPVPDDGFGDVYLVIDNYRALAEENEVLIEQVNVIINQGPSFGVHVVVTADRESELR
PPVRSGFGSRIELRLAAVEDAKLVRSRFAKDVPVKPGRGMVAVNYVRLDSDPQAGLHT
LVARPALGSTPDNVFECDSVVAAVSRLTSAQAPPVRRLPARFGVEQVRELASRDTRQG
VGAGGIAWAISELDLAPVYLNFAENSHLMVTGRRECGRTTTLATIMSEIGRLYAPGAS
SAPPPAPGRPSAQVWLVDPRRQLLTALGSDYVERFAYNLDGVVAMMGELAAALAGREP
PPGLSAEELLSRSWWSGPEIFLIVDDIQQLPPGFDSPLHKAVPFVNRAADVGLHVIVT
RTFGGWSSAGSDPMLRALHQANAPLLVMDADPDEGFIRGKMKGGPLPRGRGLLMAEDT
GVFVQVAATEVRR"
gene complement(2023447..2024628)
/gene="cyp143"
/locus_tag="Rv1785c"
CDS complement(2023447..2024628)
/codon_start=1
/transl_table=11
/gene="cyp143"
/locus_tag="Rv1785c"
/product="Probable cytochrome P450 143 Cyp143"
/note="Rv1785c, (MT1834, MTV049.07c), len: 393 aa.
Probable cyp143, cytochrome P450 (1.14.-.-), similar to
many e.g. AE0001|RZAE000101_4 Rhizobium sp. NGR234 (414
aa), FASTA scores: opt: 663, E(): 0, (32.4% identity in
413 aa overlap). Contains PS00086 Cytochrome P450 cysteine
heme-iron ligand signature. Belongs to the cytochrome P450
family."
/db_xref="EnsemblGenomes-Gn:Rv1785c"
/db_xref="EnsemblGenomes-Tr:CCP44551"
/db_xref="GOA:P9WPL3"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPL3"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP44551.1"
/translation="MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFM
NGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYF
SPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRL
IGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLS
EIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLE
PSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWG
FGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRW
S"
gene 2024828..2025031
/locus_tag="Rv1786"
CDS 2024828..2025031
/codon_start=1
/transl_table=11
/locus_tag="Rv1786"
/product="Probable ferredoxin"
/note="Rv1786, (MTV049.08), len: 67 aa. Probable
ferredoxin, similar to others e.g. X63601|FERS_STRGR
ferredoxin from Streptomyces griseus (65 aa), FASTA
scores: opt: 140, E(): 0.001, (38.1% identity in 63 aa
overlap); T50943 probable ferredoxin DitA from Pseudomonas
abietaniphila (78 aa); BAA84714.1|AB017795 ferredoxin from
Nocardioides sp. (69 aa); etc. Also similar to
Rv0763c|MTCY369.08 from Mycobacterium tuberculosis (68
aa),FASTA score: (30.6% identity in 62 aa overlap); and
Rv0763c."
/db_xref="EnsemblGenomes-Gn:Rv1786"
/db_xref="EnsemblGenomes-Tr:CCP44552"
/db_xref="UniProtKB/TrEMBL:O53937"
/protein_id="CCP44552.1"
/translation="MKVRLDPSRCVGHAQCYAVDPDLFPIDDSGNSILAEHEVRPEDM
QLTRDGVAACPEMALILEEDDAD"
gene 2025301..2026398
/gene="PPE25"
/locus_tag="Rv1787"
CDS 2025301..2026398
/codon_start=1
/transl_table=11
/gene="PPE25"
/locus_tag="Rv1787"
/product="PPE family protein PPE25"
/note="Rv1787, (MTV049.09), len: 365 aa. PPE25, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, similar to Z74024|MTCY274.24 Mycobacterium
tuberculosis cosmid (404 aa), FASTA scores: opt: 837, E():
0, (52.0% identity in 406 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1787"
/db_xref="EnsemblGenomes-Tr:CCP44553"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI13"
/protein_id="CCP44553.1"
/translation="MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATG
YASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFV
MTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASAS
ASRLIPFAAPPKTTNSAGVVAQVAAVAAMPGLLQRLSSAASVSWSNPNDWWLVRLLGS
ITPTERTTIVRLLGQSYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLG
ASRAVSASLARANKIGALSVPPSWVKTTALTESPVAHAVSANPTVGSSHGPHGLLRGL
PLGSRITRRSGAFAHRYGFRHSVVARPPSAG"
gene 2026477..2026776
/gene="PE18"
/locus_tag="Rv1788"
CDS 2026477..2026776
/codon_start=1
/transl_table=11
/gene="PE18"
/locus_tag="Rv1788"
/product="PE family protein PE18"
/note="Rv1788, (MTV049.10), len: 99 aa. PE18, Member of
the Mycobacterium tuberculosis PE family of gly-, ala-rich
proteins (see citation below), similar to
Z93777|MTCI364.07 Mycobacterium tuberculosis cosmid (99
aa), FASTA scores: opt: 414, E(): 3.6e-20, (72.4% identity
in 98 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1788"
/db_xref="EnsemblGenomes-Tr:CCP44554"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N649"
/protein_id="CCP44554.1"
/translation="MSFVTTQPEALAAAAGSLQGIGSALNAQNAAAATPTTGVVPAAA
DEVSALTAAQFAAHAQIYQAVSAQAAAIHEMFVNTLQMSSGSYAATEAANAAAAG"
gene 2026790..2027971
/gene="PPE26"
/locus_tag="Rv1789"
CDS 2026790..2027971
/codon_start=1
/transl_table=11
/gene="PPE26"
/locus_tag="Rv1789"
/product="PPE family protein PPE26"
/note="Rv1789, (MTV049.11), len: 393 aa. PPE26, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, highly similar to others e.g.Z98268|MTCI125.26
Mycobacterium tuberculosis cosmid (385 aa), FASTA score:
opt: 1283, E(): 0, (62.7% identity in 408 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1789"
/db_xref="EnsemblGenomes-Tr:CCP44555"
/db_xref="GOA:Q79FK6"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:Q79FK6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44555.1"
/translation="MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAELSSAATG
YETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAATQARAAAAAFEAAFA
ATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAEAQYGEMWAQDSAAMYAYAGSSAS
ASAVTPFSTPPQIANPTAQGTQAAAVATAAGTAQSTLTEMITGLPNALQSLTSPLLQS
SNGPLSWLWQILFGTPNFPTSISALLTDLQPYASFFYNTEGLPYFSIGMGNNFIQSAK
TLGLIGSAAPAAVAAAGDAAKGLPGLGGMLGGGPVAAGLGNAASVGKLSVPPVWSGPL
PGSVTPGAAPLPVSTVSAAPEAAPGSLLGGLPLAGAGGAGAGPRYGFRPTVMARPPFA
G"
gene 2028425..2029477
/gene="PPE27"
/locus_tag="Rv1790"
CDS 2028425..2029477
/codon_start=1
/transl_table=11
/gene="PPE27"
/locus_tag="Rv1790"
/product="PPE family protein PPE27"
/note="Rv1790, (MTV049.12), len: 350 aa. PPE27, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
protein, similar to Z74024|MTCY274.24 Mycobacterium
tuberculosis cosmid (404 aa), FASTA scores: opt: 849, E():
0, (50.0% identity in 406 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1790"
/db_xref="EnsemblGenomes-Tr:CCP44556"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q79FK5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44556.1"
/translation="MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATG
YASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFV
MTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASAS
ASRLIPFAAPPKTTNSAGVVAQAVASVSWPNPNDWWLVRLLGSITPTERTTIVRLLGQ
SYLATGMARFLTSIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAGPAVSASLARAEPV
GRLSVPPSWAVAAPAFAEKPEAGTPMSVIGEASSCGQGGLLRGIPLARAGRRTGAFAH
RYGFRHSVITRSPSAG"
gene 2029904..2030203
/gene="PE19"
/locus_tag="Rv1791"
CDS 2029904..2030203
/codon_start=1
/transl_table=11
/gene="PE19"
/locus_tag="Rv1791"
/product="PE family protein PE19"
/note="Rv1791, (MTV049.13), len: 99 aa. PE19, Member of
the Mycobacterium tuberculosis PE family, but no glycine
rich C-terminus (see Brennan & Delogu 2002), highly
similar to Z93777|MTCI364.07 M.tuberculosis cosmid (99 aa)
opt: 430 E(): 2.4e-21, (75.5% identity in 98 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1791"
/db_xref="EnsemblGenomes-Tr:CCP44557"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FK4"
/protein_id="CCP44557.1"
/translation="MSFVTTQPEALAAAAANLQGIGTTMNAQNAAAAAPTTGVVPAAA
DEVSALTAAQFAAHAQMYQTVSAQAAAIHEMFVNTLVASSGSYAATEAANAAAAG"
gene 2030347..2030643
/pseudo
/gene="esxM"
/gene_synonym="QILSS"
/gene_synonym="TB11.0"
/locus_tag="Rv1792"
CDS 2030347..2030643
/codon_start=1
/transl_table=11
/gene="esxM"
/gene_synonym="QILSS"
/gene_synonym="TB11.0"
/locus_tag="Rv1792"
/product="ESAT-6 like protein EsxM"
/note="Rv1792, (MTV049.14), len: 98 aa. EsxM, ESAT-6 like
protein (see Gey Van Pittius et al., 2001), member of
Mycobacterium tuberculosis QILSS family of proteins with
Rv1038c, Rv1197, Rv3620c and Rv2347c. Has in-frame stop
codon at 18074, no error could be found to account for
this. Identical (apart from stop codon) to
P96363|Rv1038c|MTCY10G2.11 putative ESAT-6 like protein 2
(98 aa), FASTA scores: opt: 389, E(): 5.8e-26, (100.0%
identity in 58 aa overlap). Similar protein present in
Mycobacterium leprae e.g. Q49946|MLCB1701.06C|AL049191
putative ESAT-6 like protein X (95 aa), FASTA scores: opt:
343, E(): 1.6e-17, (57.6% identity in 92 aa overlap).
Seems to belong to the ESAT6 family."
/experiment="EXISTENCE: identified in proteomics study"
/pseudogene="unknown"
gene 2030694..2030978
/gene="esxN"
/gene_synonym="ES6_5"
/gene_synonym="Mtb9.9A"
/locus_tag="Rv1793"
CDS 2030694..2030978
/codon_start=1
/transl_table=11
/gene="esxN"
/gene_synonym="ES6_5"
/gene_synonym="Mtb9.9A"
/locus_tag="Rv1793"
/product="Putative ESAT-6 like protein EsxN (ESAT-6 like
protein 5)"
/note="Rv1793, (MT1842, MTV049.15), len: 94 aa.
EsxN,ESAT-6 like protein (see citation below), almost
identical to several mycobacterial proteins of the
ESAT-6-like family including
P95242|Rv2346c|MTCY98.15C|Z83860 putative ESAT-6 like
protein 6 (94 aa), FASTA scores: opt: 610, E(): 0,(97.9 %
identity in 94 aa overlap); Rv3619c, Rv1037c, and Rv1198,
etc. Also present in Mycobacterium leprae. Seems to belong
to the ESAT6 family. Predicted possible vaccine candidate
(See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1793"
/db_xref="EnsemblGenomes-Tr:CCP44559"
/db_xref="GOA:P9WNJ3"
/db_xref="InterPro:IPR009416"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNJ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44559.1"
/translation="MTINYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGG
AGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA"
gene 2031066..2031968
/locus_tag="Rv1794"
CDS 2031066..2031968
/codon_start=1
/transl_table=11
/locus_tag="Rv1794"
/product="Conserved protein"
/note="Rv1794, (MTV049.16), len: 300 aa. Conserved
protein,slight similarity to Mycobacterium tuberculosis
O53694|Rv0289|MTV035.17, (295 aa), FASTA scores: opt:
172,E(): 0.00083, (25.7% identity in 261 aa overlap).
Equivalent to Mycobacterium leprae hypothetical protein
Q9Z5I1|MLCB596.31|AL035472 (300 aa), (88.0% identity in
300 aa overlap). Contains PS00211 ABC transporters family
signature. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1794"
/db_xref="EnsemblGenomes-Tr:CCP44560"
/db_xref="GOA:O53943"
/db_xref="InterPro:IPR025734"
/db_xref="PDB:4KXR"
/db_xref="PDB:4W4L"
/db_xref="PDB:5XFS"
/db_xref="UniProtKB/Swiss-Prot:O53943"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44560.1"
/translation="MDQQSTRTDITVNVDGFWMLQALLDIRHVAPELRCRPYVSTDSN
DWLNEHPGMAVMREQGIVVNDAVNEQVAARMKVLAAPDLEVVALLSRGKLLYGVIDDE
NQPPGSRDIPDNEFRVVLARRGQHWVSAVRVGNDITVDDVTVSDSASIAALVMDGLES
IHHADPAAINAVNVPMEEMLEATKSWQESGFNVFSGGDLRRMGISAATVAALGQALSD
PAAEVAVYARQYRDDAKGPSASVLSLKDGSGGRIALYQQARTAGSGEAWLAICPATPQ
LVQVGVKTVLDTLPYGEWKTHSRV"
gene 2032240..2033751
/gene="eccD5"
/locus_tag="Rv1795"
CDS 2032240..2033751
/codon_start=1
/transl_table=11
/gene="eccD5"
/locus_tag="Rv1795"
/product="ESX conserved component EccD5. ESX-5 type VII
secretion system protein. Probable membrane protein."
/note="Rv1795, (MTV049.17), len: 503 aa. eccD5, esx
conserved component, ESX-5 type VII secretion system
protein, probable membrane protein, has a hydrophilic
stretch from ~1-130 then very hydrophobic. Similar to
several other mycobacterial proteins, all linked to ESAT-6
family e.g. Rv3887c|MTY15F10.24|Z94121 (509 aa), FASTA
scores: opt: 360, E(): 1.6e-15, (26.7% identity in 514 aa
overlap); Rv3448, and Rv0290."
/db_xref="EnsemblGenomes-Gn:Rv1795"
/db_xref="EnsemblGenomes-Tr:CCP44561"
/db_xref="GOA:P9WNP9"
/db_xref="InterPro:IPR006707"
/db_xref="InterPro:IPR024962"
/db_xref="UniProtKB/Swiss-Prot:P9WNP9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44561.1"
/translation="MTAVADAPQADIEGVASPQAVVVGVMAGEGVQIGVLLDANAPVS
VMTDPLLKVVNSRLRELGEAPLEATGRGRWALCLVDGAPLRATQSLTEQDVYDGDRLW
IRFIADTERRSQVIEHISTAVASDLSKRFARIDPIVAVQVGASMVATGVVLATGVLGW
WRWHHNTWLTTIYTAVIGVLVLAVAMLLLMRAKTDADRRVADIMLMSAIMPVTVAAAA
APPGPVGSPQAVLGFGVLTVAAALALRFTGRRLGIYTTIVIIGALTMLAALARMVAAT
SAVTLLSSLLLICVVAYHAAPALSRRLAGIRLPVFPSATSRWVFEARPDLPTTVVVSG
GSAPVLEGPSSVRDVLLQAERARSFLSGLLTGLGVMVVVCMTSLCDPHTGQRWLPLIL
AGFTSGFLLLRGRSYVDRWQSITLAGTAVIIAAAVCVRYALELSSPLAVSIVAAILVL
LPAAGMAAAAHVPHTIYSPLFRKFVEWIEYLCLMPIFPLALWLMNVYAAIRYR"
gene 2033729..2035486
/gene="mycP5"
/locus_tag="Rv1796"
CDS 2033729..2035486
/codon_start=1
/transl_table=11
/gene="mycP5"
/locus_tag="Rv1796"
/product="Probable proline rich membrane-anchored mycosin
MycP5 (serine protease) (subtilisin-like protease)
(subtilase-like) (mycosin-5)"
/note="Rv1796, (MTV049.18), len: 585 aa. Probable
mycP5,pro-rich membrane-anchored serine protease (mycosin)
(see citations below). Member of family with four other
Mycobacterium tuberculosis serine proteases:
Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa), FASTA scores:
opt: 1173, E(): 0, (47.9% identity in 578 aa overlap);
Rv0291, Rv3883c, and Rv3449. Genes all linked to those of
ESAT-6 family. Has possible N-terminal signal peptide and
hydrophobic anchor-like stretch at C-terminus. Contains
two serine protease, subtilase family active site motifs:
a aspartic acid active site motif (PS00136); and a
histidine active site motif (PS00137). Belongs to
peptidase family S8 (also known as the subtilase family),
pyrolysin subfamily. Conserved in M. tuberculosis, M.
leprae, M. bovis and M. avium paratuberculosis; predicted
to be essential for in vivo survival and pathogenicity
(See Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1796"
/db_xref="EnsemblGenomes-Tr:CCP44562"
/db_xref="GOA:O53945"
/db_xref="InterPro:IPR000209"
/db_xref="InterPro:IPR015500"
/db_xref="InterPro:IPR023827"
/db_xref="InterPro:IPR023834"
/db_xref="InterPro:IPR036852"
/db_xref="UniProtKB/Swiss-Prot:O53945"
/inference="protein motif:PROSITE:PS00136"
/inference="protein motif:PROSITE:PS00137"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44562.1"
/translation="MQRFGTGSSRSWCGRAGTATIAAVLLASGALTGLPPAYAISPPT
IDPGALPPDGPPGPLAPMKQNAYCTEVGVLPGTDFQLQPKYMEMLNLNEAWQFGRGDG
VKVAVIDTGVTPHPRLPRLIPGGDYVMAGGDGLSDCDAHGTLVASMIAAVPANGAVPL
PSVPRRPVTIPTTETPPPPQTVTLSPVPPQTVTVIPAPPPEEGVPPGAPVPGPEPPPA
PGPQPPAVDRGGGTVTVPSYSGGRKIAPIDNPRNPHPSAPSPALGPPPDAFSGIAPGV
EIISIRQSSQAFGLKDPYTGDEDPQTAQKIDNVETMARAIVHAANMGASVINISDVMC
MSARNVIDQRALGAAVHYAAVDKDAVIVAAAGDGSKKDCKQNPIFDPLQPDDPRAWNA
VTTVVTPSWFHDYVLTVGAVDANGQPLSKMSIAGPWVSISAPGTDVVGLSPRDDGLIN
AIDGPDNSLLVPAGTSFSAAIVSGVAALVRAKFPELSAYQIINRLIHTARPPARGVDN
QVGYGVVDPVAALTWDVPKGPAEPPKQLSAPLVVPQPPAPRDMVPIWVAAGGLAGALL
IGGAVFGTATLMRRSRKQQ"
gene 2035483..2036703
/gene="eccE5"
/locus_tag="Rv1797"
CDS 2035483..2036703
/codon_start=1
/transl_table=11
/gene="eccE5"
/locus_tag="Rv1797"
/product="ESX conserved component EccE5. ESX-5 type VII
secretion system protein. Probable membrane protein."
/note="Rv1797, (MTV049.19), len: 406 aa. eccE5, esx
conserved component, ESX-5 type VII secretion system
protein, probable membrane protein, some similarity to
Mycobacterium tuberculosis
O05462|Rv3882c|MTCY15F10.30|Z94121 (462 aa), FASTA scores:
opt: 181, E(): 9.2e-05, (25.4% identity in 283 aa
overlap). Has two hydrophobic stretch near N-terminus. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1797"
/db_xref="EnsemblGenomes-Tr:CCP44563"
/db_xref="GOA:P9WJE3"
/db_xref="InterPro:IPR021368"
/db_xref="UniProtKB/Swiss-Prot:P9WJE3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44563.1"
/translation="MKAQRSFGLALSWPRVTAVFLVDVLILAVASHCPDSWQADHHVA
WWVGVGVAAVVTLLSVVSYHGITVISGLATWVRDWSADPGTTLGAGCTPAIDHQRRFG
RDTVGVREYNGRLVSVIEVTCGESGPSGRHWHRKSPVPMLPVVAVADGLRQFDIHLDG
IDIVSVLVRGGVDAAKASASLQEWEPQGWKSEERAGDRTVADRRRTWLVLRMNPQRNV
AAVACRDSLASTLVAATERLVQDLDGQSCAARPVTADELTEVDSAVLADLEPTWSRPG
WRHLKHFNGYATSFWVTPSDITSETLDELCLPDSPEVGTTVVTVRLTTRVGSPALSAW
VRYHSDTRLPKEVAAGLNRLTGRQLAAVRASLPAPTHRPLLVIPSRNLRDHDELVLPV
GQELEHATSSFVGQ"
gene 2036700..2038532
/gene="eccA5"
/locus_tag="Rv1798"
CDS 2036700..2038532
/codon_start=1
/transl_table=11
/gene="eccA5"
/locus_tag="Rv1798"
/product="ESX conserved component EccA5. ESX-5 type VII
secretion system protein."
/note="Rv1798, (MTV049.20), len: 610 aa. eccA5, esx
conserved component, ESX-5 type VII secretion system
protein, similar to several mycobacterial proteins e.g.
O05460|MTCY15F10.28|Rv3884c|Z94121 from M. tuberculosis
(619 aa), FASTA scores: opt: 669, E(): 0, (31.0% identity
in 549 aa overlap); and O33089|MLCB628.18c|Y14967 from
Mycobacterium leprae (573 aa), FASTA scores: opt: 723,
E(): 0, (32.4% identity in 568 aa overlap). Also very
similar to Rv0282. May belong to the CbxX/CfqX family as
last ~320 aa domain very similar to several family
members. Contains ATP/GTP-binding site motif A (P-loop;
PS00017)."
/db_xref="EnsemblGenomes-Gn:Rv1798"
/db_xref="EnsemblGenomes-Tr:CCP44564"
/db_xref="GOA:P9WPI1"
/db_xref="InterPro:IPR000641"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR023835"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041627"
/db_xref="UniProtKB/Swiss-Prot:P9WPI1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44564.1"
/translation="MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTT
ATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGL
FLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRT
KRWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGA
ANIALYTQGMCLRHVGREEEAVELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIE
ARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTK
VNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTK
LLGRYMADAEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMEN
HRDELVVFGAGYAKAMEKMLEVNQGLRRRFSTVIEFFSYTPQELIALTQLMGRENEDV
ITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHRSFRLDD
EDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK"
gene 2039159..2039350
/gene="lppT"
/locus_tag="Rv1799"
CDS 2039159..2039350
/codon_start=1
/transl_table=11
/gene="lppT"
/locus_tag="Rv1799"
/product="Probable lipoprotein LppT"
/note="Rv1799, (MTV049.21), len: 63 aa. Probable lppT
lipoprotein, has possible signal peptide and appropriately
positioned PS00013 Prokaryotic membrane lipoprotein lipid
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1799"
/db_xref="EnsemblGenomes-Tr:CCP44565"
/db_xref="UniProtKB/TrEMBL:O53948"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP44565.1"
/translation="MSVKSKNGRLAARVLVALAALFAMIALTGSACLAEGPPLGRNPQ
GAPAPVGGTVIVAPMHSGV"
gene 2039453..2041420
/gene="PPE28"
/locus_tag="Rv1800"
CDS 2039453..2041420
/codon_start=1
/transl_table=11
/gene="PPE28"
/locus_tag="Rv1800"
/product="PPE family protein PPE28"
/note="Rv1800, (MTV049.22), len: 655 aa. PPE28, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, C-terminal very similar to parts of PE proteins
e.g. Z92770|MTCI5.25|Rv0151c (588 aa), FASTA scores: opt:
1269, E(): 0, (41.5% identity in 591 aa overlap).
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1800"
/db_xref="EnsemblGenomes-Tr:CCP44566"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI11"
/protein_id="CCP44566.1"
/translation="MLPNFAVLPPEVNSARVFAGAGSAPMLAAAAAWDDLASELHCAA
MSFGSVTSGLVVGWWQGSASAAMVDAAASYIGWLSTSAAHAEGAAGLARAAVSVFEEA
LAATVHPAMVAANRAQVASLVASNLFGQNAPAIAALESLYECMWAQDAAAMAGYYVGA
SAVATQLASWLQRLQSIPGAASLDARLPSSAEAPMGVVRAVNSAIAANAAAAQTVGLV
MGGSGTPIPSARYVELANALYMSGSVPGVIAQALFTPQGLYPVVVIKNLTFDSSVAQG
AVILESAIRQQIAAGNNVTVFGYSQSATISSLVMANLAASADPPSPDELSFTLIGNPN
NPNGGVATRFPGISFPSLGVTATGATPHNLYPTKIYTIEYDGVADFPRYPLNFVSTLN
AIAGTYYVHSNYFILTPEQIDAAVPLTNTVGPTMTQYYIIRTENLPLLEPLRSVPIVG
NPLANLVQPNLKVIVNLGYGDPAYGYSTSPPNVATPFGLFPEVSPVVIADALVAGTQQ
GIGDFAYDVSHLELPLPADGSTMPSTAPGSGTPVPPLSIDSLIDDLQVANRNLANTIS
KVAATSYATVLPTADIANAALTIVPSYNIHLFLEGIQQALKGDPMGLVNAVGYPLAAD
VALFTAAGGLQLLIIISAGRTIANDISAIVP"
gene 2042001..2043272
/gene="PPE29"
/locus_tag="Rv1801"
CDS 2042001..2043272
/codon_start=1
/transl_table=11
/gene="PPE29"
/locus_tag="Rv1801"
/product="PPE family protein PPE29"
/note="Rv1801, (MTV049.23), len: 423 aa. PPE29, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, most similar to AL022021|MTV049.29|Rv1808 (409
aa), FASTA scores: opt: 1229, E(): 0, (55.2% identity in
422 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1801"
/db_xref="EnsemblGenomes-Tr:CCP44567"
/db_xref="GOA:P9WI09"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI09"
/protein_id="CCP44567.1"
/translation="MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAG
YASELSALTGAWSGPSSTSMASAAAPYVAWMSATAVHAELAGAQARLAIAAYEAAFAA
TVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYMEMWAQDAAAMYGYAGSSATA
SRMTAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPRALQGLALP
TASQSASATPQWVTDLGNLSTFLGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQ
GVSALLGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQ
GWTVAAPEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIG
SAAAPAVGAAAAAVEDLATEANIFVIPAMDD"
gene 2043384..2044775
/gene="PPE30"
/locus_tag="Rv1802"
CDS 2043384..2044775
/codon_start=1
/transl_table=11
/gene="PPE30"
/locus_tag="Rv1802"
/product="PPE family protein PPE30"
/note="Rv1802, (MTV049.24), len: 463 aa. PPE30, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, most similar to AL022021|MTV049.30|Rv1809 (468
aa), FASTA scores: opt: 1238, E(): 0, (51.0% identity in
471 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1802"
/db_xref="EnsemblGenomes-Tr:CCP44568"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI07"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44568.1"
/translation="MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATELQSTAAD
YGSVISVLTGVWSGQSSGTMAAAAAPYVAWMSATAALAREAAAQASAAAAAYEAAFAA
TVPPPVVAANRAELAVLAATNIFGQNTGAIAAAEARYAEMWAQDAAAMYGYAGSSSVA
TQVTPFAAPPPTTNAAGLATQGVAVAQAVGASAGNARSLVSEVLEFLATAGTNYNKTV
ASLMNAVTGVPYASSVYNSMLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTPF
NPDLIPKSALGAGLGLRSAISSGLGSTAPAISAGASQAGSVGGMSVPPSWAAATPAIR
TVAAVFSSTGLQAVPAAAISEGSLLSQMALASVAGGALGGAAARATGGFLGGGRVTAV
KKSLKDSDSPDKLRRVVAHMMEKPESVQHWHTDEDGLDDLLAELKKKPGIHAVHMAGG
NKAEIAPTISESG"
gene complement(2044923..2046842)
/gene="PE_PGRS32"
/locus_tag="Rv1803c"
CDS complement(2044923..2046842)
/codon_start=1
/transl_table=11
/gene="PE_PGRS32"
/locus_tag="Rv1803c"
/product="PE-PGRS family protein PE_PGRS32"
/note="Rv1803c, (MTV049.25c), len: 639 aa.
PE_PGRS32,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below). Most similar to Rv1768|MTCY28.34|Z95890 (618 aa),
FASTA scores: opt: 1827, E(): 0, (53.5% identity in 664 aa
overlap). Contains two PS00583 pfkB family of carbohydrate
kinases signatures 1. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1803c"
/db_xref="EnsemblGenomes-Tr:CCP44569"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FJ9"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44569.1"
/translation="MWTSQMIVAPAFVDAAAKDLATIGSAISRANAEALVPITALLPA
GADDVSAAIAALFATHGQAYQELSAHAVAFHEQFVQLMSAGAAQYASAEAANSSPLQI
VGQTALDAINSPVQTLTGRPLIGNGANGVAGTGQNGGDGGWLYGNGGNGGSGGTGQNG
GNGGSAGLWGSGGNGGQGGAGANGAAGQPGKAGGSGGNGGAGGWIYGHGGHGGAGGNG
GNATAPGGASAGFDGGAGGNGGSGGRGGLLFGNGGNGSVGGMGGQGTNDTAGDSAGSG
GLGGNGGNGAQGGWLIGNGGQGGDSGAGGGTDSTQTGVMNGASGGSAGIAGNGGDAGL
VGNGGAGGNGGNGAAGSALGTTIFGGSGGVGGSGGDGGNGGWLFGSGASGGNGGQGGD
AGTNGFAGFGGSAGGGGWVGAVNFGPISVQGFGLFGHGGDGGNGGDVGAGSLSIQFGA
SGGDGGQGGVLYGNGGNGGNAGSGGGTGFEGSAGQGGAAILIGNGGAGGNGATGGTGV
GNIIQEAGGDGSDGGAGGSGGLLFGSGGAGGIGGAGGVGGSGNDGGNGGDGGQGGASG
LGIGNGGPGGSGGTGGAGGTGGSAGTGGAGGDGGNAALLIGTGGDGGDGVPPAPGGQG
GKGGLIGLPGQNGQP"
gene complement(2047023..2047349)
/locus_tag="Rv1804c"
CDS complement(2047023..2047349)
/codon_start=1
/transl_table=11
/locus_tag="Rv1804c"
/product="Conserved protein"
/note="Rv1804c, (MTV049.26c), len: 108 aa. Conserved
protein, similar to several hypothetical Mycobacterium
tuberculosis proteins that may be exported (hydrophobic
stretch at N-terminus) e.g.
O07222|Rv1810|MTCY16F9.04C|Z96073 (118 aa), FASTA scores:
opt: 361, E(): 2.3e-19, (53.5% identity in 101 aa
overlap); Rv0622, Rv1690, and Rv3067, etc. Predicted to be
an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1804c"
/db_xref="EnsemblGenomes-Tr:CCP44570"
/db_xref="GOA:O53953"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/TrEMBL:O53953"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44570.1"
/translation="MRVVSTLLSIPLMIGLAVPAHAGPSGDDAVFLASLERAGITYSH
PDQAIASGKAVCALVESGESGLQVVNELRTRNPGFSMDGCCKFAAISAHVYCPHQITK
TSVSAK"
gene complement(2047687..2048034)
/locus_tag="Rv1805c"
CDS complement(2047687..2048034)
/codon_start=1
/transl_table=11
/locus_tag="Rv1805c"
/product="Hypothetical protein"
/note="Rv1805c, (MTV049.27c), len: 115 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1805c"
/db_xref="EnsemblGenomes-Tr:CCP44571"
/db_xref="GOA:O53954"
/db_xref="UniProtKB/TrEMBL:O53954"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44571.1"
/translation="MTASVVATSRERHSHKAAKQRACEITDFEPEGRFRVRKRRRGRI
GTKRSSISDTDYRRDSFRSHLLTAGAHGDADAQHKGMTAQQTTELGTPLVRALAPHGV
SGRSSRKPLGLNP"
gene 2048072..2048371
/gene="PE20"
/locus_tag="Rv1806"
CDS 2048072..2048371
/codon_start=1
/transl_table=11
/gene="PE20"
/locus_tag="Rv1806"
/product="PE family protein PE20"
/note="Rv1806, (MTV049.28), len: 99 aa. PE20, Member of
the Mycobacterium tuberculosis PE family of gly-, ala-rich
proteins (see citation below), most similar to
Rv1788|MTV049.10|AL022021 (99 aa), FASTA scores: opt:
334,E(): 4.7 e-15, (59.8% identity in 97 aa overlap). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1806"
/db_xref="EnsemblGenomes-Tr:CCP44572"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N656"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44572.1"
/translation="MAFVLVCPDALAIAAGQLRHVGSVIAARNAVAAPATAELAPAAA
DEVSALTATQFNFHAAMYQAVGAQAIAMNEAFVAMLGASADSYAATEAANIIAVS"
gene <2048398..2049597
/gene="PPE31"
/locus_tag="Rv1807"
CDS <2048398..2049597
/codon_start=1
/transl_table=11
/gene="PPE31"
/locus_tag="Rv1807"
/product="PPE family protein PPE31"
/note="Rv1807, (MTV049.29), len: 399 aa. PPE31, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, most similar to Rv1789|MTV049.11|AL022021 (393
aa), FASTA scores: opt: 1169, E(): 0, (49.5% identity in
412 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1807"
/db_xref="EnsemblGenomes-Tr:CCP44573"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:L0T7Y7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44573.1"
/translation="LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAELRASALS
YSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAGAQAEAAAAAYEAAFA
ATVPPPVIEANRAQLMALIATNVLGQNAPAIAATEAQYAEMWSQDAMAMYGYAGASAA
ATQLTPFTEPVQTTNASGLAAQSAAIAHATGASAGAQQTTLSQLIAAIPSVLQGLSSS
TAATFASGPSGLLGIVGSGSSWLDKLWALLDPNSNFWNTIASSGLFLPSNTIAPFLGL
LGGVAAADAAGDVLGEATSGGLGGALVAPLGSAGGLGGTVAAGLGNAATVGTLSVPPS
WTAAAPLASPLGSALGGTPMVAPPPAVAAGMPGMPFGTMGGQGFGRAVPQYGFRPNFV
ARPPAAG"
gene 2049921..2051150
/gene="PPE32"
/locus_tag="Rv1808"
CDS 2049921..2051150
/codon_start=1
/transl_table=11
/gene="PPE32"
/locus_tag="Rv1808"
/product="PPE family protein PPE32"
/note="Rv1808, (MTV049.30), len: 409 aa. PPE32, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, most similar to Rv1800|MTV049.22|AL022021 (655
aa), FASTA scores: opt: 1225, E(): 0, (55.1% identity in
423 aa overlap). Contains PS00343 Gram-positive cocci
surface proteins 'anchoring' hexapeptide. Nucleotide
position 2050913 in the genome sequence has been
corrected,A:G resulting in E331E."
/db_xref="EnsemblGenomes-Gn:Rv1808"
/db_xref="EnsemblGenomes-Tr:CCP44574"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI05"
/inference="protein motif:PROSITE:PS00343"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44574.1"
/translation="MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAAS
YGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFA
ATVPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSAT
ASQLAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLAT
TATATSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGV
AALLGPKAAAGALSPLAPLRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAP
VMRAVASVLPGTGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRSGAGAARVAGGS
VTEDVASTTTIIVIPAD"
gene 2051282..2052688
/gene="PPE33"
/locus_tag="Rv1809"
CDS 2051282..2052688
/codon_start=1
/transl_table=11
/gene="PPE33"
/locus_tag="Rv1809"
/product="PPE family protein PPE33"
/note="Rv1809, (MTV049.31), len: 468 aa. PPE33, Member of
the Mycobacterium tuberculosis PPE family of glycine-rich
proteins, most similar to RV1802AL022021|MTV049.23 (463
aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in
471 aa overlap). Alternative nucleotide at position
2051746 (T->C; A155A) has been observed."
/db_xref="EnsemblGenomes-Gn:Rv1809"
/db_xref="EnsemblGenomes-Tr:CCP44575"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44575.1"
/translation="MDFGLQPPEITSGEMYLGPGAGPMLAAAVAWDGLAAELQSMAAS
YASIVEGMASESWLGPSSAGMAAAAAPYVTWMSGTSAQAKAAADQARAAVVAYETAFA
AVVPPPQIAANRSQLISLVATNIFGQNTAAIAATEAEYGEMWAQDTMAMFGYASSSAT
ASRLTPFTAPPQTTNPSGLAGQAAATGQATALASGTNAVTTALSSAAAQFPFDIIPTL
LQGLATLSTQYTQLMGQLINAIFGPTGATTYQNVFVTAANVTKFSTWANDAMSAPNLG
MTEFKVFWQPPPAPEIPKSSLGAGLGLRSGLSAGLAHAASAGLGQANLVGDLSVPPSW
ASATPAVRLVANTLPATSLAAAPATQIPANLLGQMALGSMTGGALGAAAPAIYTGSGA
RARANGGTPSAEPVKLEAVIAQLQKQPDAVRHWNVDKADLDGLLDRLSKQPGIHAVHV
SNGDKPKVALPDTQLGSH"
gene 2052933..2053289
/locus_tag="Rv1810"
CDS 2052933..2053289
/codon_start=1
/transl_table=11
/locus_tag="Rv1810"
/product="Conserved protein"
/note="Rv1810, (MTCY16F9.04c), len: 118 aa. Conserved
protein, similar to several hypothetical Mycobacterium
tuberculosis proteins that may be exported (possible
N-terminal signal sequence) e.g.
O53953|Rv1804c|MTV049.26c|AL022021 (108 aa), FASTA scores:
opt: 361, E(): 9.6e-17, (53.5% identity in 101 aa
overlap); Rv0622, and Rv1690, etc."
/db_xref="EnsemblGenomes-Gn:Rv1810"
/db_xref="EnsemblGenomes-Tr:CCP44576"
/db_xref="GOA:O07222"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/TrEMBL:O07222"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44576.1"
/translation="MQLQRTMGQCRPMRMLVALLLSAATMIGLAAPGKADPTGDDAAF
LAALDQAGITYADPGHAITAAKAMCGLCANGVTGLQLVADLRDYNPGLTMDSAAKFAA
IASGAYCPEHLEHHPS"
gene 2053443..2054147
/gene="mgtC"
/locus_tag="Rv1811"
CDS 2053443..2054147
/codon_start=1
/transl_table=11
/gene="mgtC"
/locus_tag="Rv1811"
/product="Possible Mg2+ transport P-type ATPase C MgtC"
/note="Rv1811, (MTCY16F9.03c), len: 234 aa. Possible
mgtC,magnesium (Mg2+) transport P-type ATPase C
(transmembrane protein), highly similar to many e.g.
NP_442124.1|NC_000911 Mg2+ transport ATPase from
Synechocystis sp. strain PCC 6803 (234 aa);
NP_251248.1|NC_002516 probable transport protein from
Pseudomonas aeruginosa (230 aa); P22037|ATMC_SALTY|STM3764
magnesium transport ATPase protein C from Salmonella
typhimurium (231 aa), FASTA scores: opt: 545, E():
4.1e-30, (42.3% identity in 220 aa overlap); N-terminus of
NP_213315.1|NC_000918 Mg(2+) transport ATPase from Aquifex
aeolicus (225 aa); etc. Belongs to the MGTC / SAPB family"
/db_xref="EnsemblGenomes-Gn:Rv1811"
/db_xref="EnsemblGenomes-Tr:CCP44577"
/db_xref="GOA:I6YBN6"
/db_xref="InterPro:IPR003416"
/db_xref="UniProtKB/TrEMBL:I6YBN6"
/protein_id="CCP44577.1"
/translation="MQTLTVADFALRLAVGVGCGAIIGLERQWRARMAGLRTNALVAT
GATLFVLYAVATEDSSPTRVASYVVSGIGFLGGGVILREGFNVRGLNTAATLWCSAAV
GVLAASGHLVFTLIGTGTIVAVHLLGRPLGRLVDRDNAVEDEGLQPYQVRVICRPKAE
TYVRAHIVQRTSSNDITLRGIRTGPAGDDNITLTAHLLMVGHTPAKLERLVAELSLQP
GVYAVHWYAGEHAQAE"
gene complement(2054157..2055359)
/locus_tag="Rv1812c"
CDS complement(2054157..2055359)
/codon_start=1
/transl_table=11
/locus_tag="Rv1812c"
/product="Probable dehydrogenase"
/note="Rv1812c, (MTCY16F9.02), len: 400 aa. Probable
dehydrogenase, similar to other dehydrogenases/oxidases
e.g. AE001947|AE001947_10 NADH dehydrogenase II of
Deinococcus radiodurans (379 aa), FASTA scores: opt:
404,E(): 3.4e-18, (26.4% identity in 363 aa overlap) and
DHNA_HAEIN|P44856 nadh dehydrogenase (444 aa), FASTA
scores: opt: 200, E(): 8.5e-06, (23.3% identity in 258 aa
overlap). Also similar to Mycobacterium tuberculosis
hypothetical dehydrogenases Rv0392c, and
Rv1854c|MTCY359.19 ndh probable NADH dehydrogenase (31.5%
identity in 321 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1812c"
/db_xref="EnsemblGenomes-Tr:CCP44578"
/db_xref="GOA:P9WJJ1"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WJJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44578.1"
/translation="MTRVVVIGSGFAGLWAALGAARRLDELAVLAGTVDVMVVSNKPF
HDIRVRNYEADLSACRIPLGDVLGPAGVAHVTAEVTAIDADGRRVTTSTGASYSYDRL
VLASGSHVVKPALPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPLTSAAATVVVVGAGL
TGIETACELPGRLHALFARGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALLDNGVE
TRTGVSVAAVSPGGVTLSSGERLAAATVVWCAGMRASRLTEQLPVARDRLGRLQVDDY
LRVIGVPAMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALRI
PWYVTVLDLGSAGAVYTEGWERKVVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAA
APRVQPRP"
gene complement(2055681..2056112)
/locus_tag="Rv1813c"
CDS complement(2055681..2056112)
/codon_start=1
/transl_table=11
/locus_tag="Rv1813c"
/product="Conserved hypothetical protein"
/note="Rv1813c, (MTCY16F9.01), len: 143 aa. Conserved
hypothetical protein. Possibly a exported protein with
potential N-terminal signal sequence. Similar to
Q11050|Rv1269c|MTCY50.13 hypothetical protein from
Mycobacterium tuberculosis (124 aa), (42.7% identity in
143 aa overlap). Predicted to be an outer membrane protein
(See Song et al., 2008). Predicted possible vaccine
candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1813c"
/db_xref="EnsemblGenomes-Tr:CCP44579"
/db_xref="InterPro:IPR025240"
/db_xref="UniProtKB/Swiss-Prot:P9WLS1"
/protein_id="CCP44579.1"
/translation="MITNLRRRTAMAAAGLGAALGLGILLVPTVDAHLANGSMSEVMM
SEIAGLPIPPIIHYGAIAYAPSGASGKAWHQRTPARAEQVALEKCGDKTCKVVSRFTR
CGAVAYNGSKYQGGTGLTRRAAEDDAVNRLEGGRIVNWACN"
gene 2056521..2057423
/gene="erg3"
/locus_tag="Rv1814"
CDS 2056521..2057423
/codon_start=1
/transl_table=11
/gene="erg3"
/locus_tag="Rv1814"
/product="Membrane-bound C-5 sterol desaturase Erg3
(sterol-C5-desaturase)"
/note="Rv1814, (MTCY1A11.29c), len: 300 aa.
Erg3,transmembrane C-5 sterol desaturase (see *), weak
similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol
desaturase (365 aa), FASTA scores: opt: 154, E():
0.0011,(22.9% identity in 288 aa overlap). Belongs to the
sterol desaturase family. [* Note: work of Jackson, C.J.,
Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a
sterol delta 5,6-desaturase homolog in Mycobacterium bovis
(BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ
databases]."
/db_xref="EnsemblGenomes-Gn:Rv1814"
/db_xref="EnsemblGenomes-Tr:CCP44580"
/db_xref="GOA:P9WNZ9"
/db_xref="InterPro:IPR006694"
/db_xref="UniProtKB/Swiss-Prot:P9WNZ9"
/protein_id="CCP44580.1"
/translation="MRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAY
LTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVD
LLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPP
WMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGIL
IIWDRLFGSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYV
FGPPGWEPRTIDKSNAAASLVTSR"
gene 2057528..2058193
/locus_tag="Rv1815"
CDS 2057528..2058193
/codon_start=1
/transl_table=11
/locus_tag="Rv1815"
/product="Conserved protein"
/note="Rv1815, (MTCY1A11.28c), len: 221 aa. Conserved
protein, similar to G473456 hypothetical protein from
Mycobacterium fortuitum (255 aa), FASTA scores: opt:
182,E(): 3.2e-05, (29.6% identity in 230 aa overlap).
Alternative nucleotide at position 2057774 (a->T; I83F)
has been observed. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1815"
/db_xref="EnsemblGenomes-Tr:CCP44581"
/db_xref="GOA:P9WLR9"
/db_xref="InterPro:IPR009003"
/db_xref="UniProtKB/Swiss-Prot:P9WLR9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44581.1"
/translation="MVRLVPRAFAATVALLAAGFSPATASADPVLVFPGMEIRQDNHV
CTLGYVDPALKIAFTAGHCRGGGAVTSRDYKVIGHLRAIRDNTPSGSTVATHELIADY
EAIVLADDVTASNILPSGRALESRPGVVLHPGQAVCHFGVSTGETCGTVESVNNGWFT
MSHGVLSEKGDSGGPVYLAPDGGPAQIVGIFNSVWGGFPAAVSWRSTSEQVHADLGVT
PLA"
gene 2058256..2058960
/locus_tag="Rv1816"
CDS 2058256..2058960
/codon_start=1
/transl_table=11
/locus_tag="Rv1816"
/product="Possible transcriptional regulatory protein"
/note="Rv1816, (MTCY1A11.27c), len: 234 aa. Possible
transcriptional regulatory protein. MEME analysis suggests
similarity to putative Mycobacterium tuberculosis
transcriptional regulators, Rv0653c, Rv0681. Contains
helix-turn-helix motif at aa 38-59 (+4.30 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1816"
/db_xref="EnsemblGenomes-Tr:CCP44582"
/db_xref="GOA:P9WMC9"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR025996"
/db_xref="InterPro:IPR036271"
/db_xref="PDB:5D1R"
/db_xref="UniProtKB/Swiss-Prot:P9WMC9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44582.1"
/translation="MCQTCRVGKRRDAREQIEAKIVELGRRQLLDHGAAGLSLRAIAR
NLGMVSSAVYRYVSSRDELLTLLLVDAYSDLADTVDRARDDTVADSWSDDVIAIARAV
RGWAVTNPARWALLYGSPVPGYHAPPDRTAGVATRVVGAFFDAIAAGIATGDIRLTDD
VAPQPMSSDFEKIRQEFGFPGDDRVVTKCFLLWAGVVGAISLEVFGQYGADMLTDPGV
VFDAQTRLLVAVLAEH"
repeat_region 2059441..2059498
/note="58 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
repeat_region 2059518..2059575
/note="58 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene 2059595..2061058
/locus_tag="Rv1817"
CDS 2059595..2061058
/codon_start=1
/transl_table=11
/locus_tag="Rv1817"
/product="Possible flavoprotein"
/note="Rv1817, (MTCY1A11.26c), len: 487 aa. Possible
flavoprotein, similar to G746486 flavoprotein subunit of
fumarate reductase FAD domain homologue (474 aa), FASTA
scores: opt: 223, E(): 5.7e-07, (24.1% identity in 489 aa
overlap); and AJ236923|SFR236923_3 soluble fumarate
reductase of Shewanella frigidimarina ifcA (588 aa), FASTA
scores: opt: 310, E(): 2.5e-11, (27.3% identity in 484 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1817"
/db_xref="EnsemblGenomes-Tr:CCP44583"
/db_xref="GOA:Q50616"
/db_xref="InterPro:IPR003953"
/db_xref="InterPro:IPR027477"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:Q50616"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44583.1"
/translation="MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGA
RVLVLERAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYLVAVSREPDHDK
IRAYCDGSVEHFNWLEGLGFQFERSYFPGKAVIQPNTEGLMFTGNEKVWPFLELAVPA
PRGHKVPVPGDTGGAAMVIDLLLKRAASLGIQIRYETGATELIVDGTGKVTGVMWKRF
SETGAIKAKSVIIAAGGFVMNPDMVAKYTPKLAEKPFVLGNTYDDGLGIRLGVSAGGA
TQHMDQMFITAPPYPPSILLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIV
DEAHLEHPKMPLVPLIDGWETVVEMEAALGIPPGNLAATLDRYNAYAARGADPDFHKQ
PEFLAAQDNGPWGAFDMSLGKAMYAGFTLGGLATSVDGQVLRDDGAVVAGLYAVGACA
SNIAQDGKGYASGTQLGEGSFFGRRAGAHAAARAQGM"
gene complement(2061178..2062674)
/gene="PE_PGRS33"
/locus_tag="Rv1818c"
CDS complement(2061178..2062674)
/codon_start=1
/transl_table=11
/gene="PE_PGRS33"
/locus_tag="Rv1818c"
/product="PE-PGRS family protein PE_PGRS33"
/note="Rv1818c, (MTCY1A11.25), len: 498 aa.
PE_PGRS33,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins, similar to
many. Contains 2 x PS00583 pfkB family of carbohydrate
kinases signature 1. Supposedly localised to the cell
surface (see citations below)."
/db_xref="EnsemblGenomes-Gn:Rv1818c"
/db_xref="EnsemblGenomes-Tr:CCP44584"
/db_xref="GOA:P9WIF5"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIF5"
/inference="protein motif:PROSITE:PS00583"
/protein_id="CCP44584.1"
/translation="MSFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAA
DEVSAAMAALFSGHAQAYQALSAQAALFHEQFVRALTAGAGSYAAAEAASAAPLEGVL
DVINAPALALLGRPLIGNGANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAA
GLFGNGGAGGAGGNVASGTAGFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGA
GGNGGLLFGAGGAGGVGGLAADAGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGA
GGNGGLLFGAGGVGGVGGDGVAFLGTAPGGPGGAGGAGGLFGVGGAGGAGGIGLVGNG
GAGGSGGSALLWGDGGAGGAGGVGSTTGGAGGAGGNAGLLVGAGGAGGAGALGGGATG
VGGAGGNGGTAGLLFGAGGAGGFGFGGAGGAGGLGGKAGLIGDGGDGGAGGNGTGAKG
GDGGAGGGAILVGNGGNGGNAGSGTPNGSAGTGGAGGLLGKNGMNGLP"
gene complement(2062809..2064728)
/gene="bacA"
/locus_tag="Rv1819c"
CDS complement(2062809..2064728)
/codon_start=1
/transl_table=11
/gene="bacA"
/locus_tag="Rv1819c"
/product="Probable drug-transport transmembrane
ATP-binding protein ABC transporter BacA"
/note="Rv1819c, (MTCY1A11.24), len: 639 aa. Probable
bacA,drug-transport transmembrane ATP-binding protein ABC
transporter (see citation below), equivalent to
AL008609|MLCB1788.47 hypothetical ABC transporter from
Mycobacterium leprae (638 aa), (74.9% identity in 634 aa
overlap). Also similar to other transmembrane ATP-binding
proteins e.g. Q57335|Y036_HAEIN hypothetical ABC
transporter ATP-binding protein from Haemophilus
influenzae (592 aa), FASTA scores: opt: 1235, E():
2.8e-61, (40.8% identity in 623 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211
ABC transporters family signature. Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1819c"
/db_xref="EnsemblGenomes-Tr:CCP44585"
/db_xref="GOA:P9WQI9"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="UniProtKB/Swiss-Prot:P9WQI9"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44585.1"
/translation="MGPKLFKPSIDWSRAFPDSVYWVGKAWTISAICVLAILVLLRYL
TPWGRQFWRITRAYFVGPNSVRVWLMLGVLLLSVVLAVRLNVLFSYQGNDMYTALQKA
FEGIASGDGTVKRSGVRGFWMSIGVFSVMAVLHVTRVMADIYLTQRFIIAWRVWLTHH
LTQDWLDGRAYYRDLFIDETIDNPDQRIQQDVDIFTAGAGGTPNAPSNGTASTLLFGA
VQSIISVISFTAILWNLSGTLNIFGVSIPRAMFWTVLVYVFVATVISFIIGRPLIWLS
FRNEKLNAAFRYALVRLRDAAEAVGFYRGERVEGTQLQRRFTPVIDNYRRYVRRSIAF
NGWNLSVSQTIVPLPWVIQAPRLFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFA
SFRAAIIRLHGLVDANEKGRALPAVLTRPSDDESVELNDIEVRTPAGDRLIDPLDVRL
DRGGSLVITGRSGAGKTTLLRSLAELWPYASGTLHRPGGENETMFLSQLPYVPLGTLR
DVVCYPNSAAAIPDATLRDTLTKVALAPLCDRLDEERDWAKVLSPGEQQRVAFARILL
TKPKAVFLDESTSALDTGLEFALYQLLRSELPDCIVISVSHRPALERLHENQLELLGG
GQWRLAPVEAAPAEV"
gene 2064799..2066442
/gene="ilvG"
/locus_tag="Rv1820"
CDS 2064799..2066442
/codon_start=1
/transl_table=11
/gene="ilvG"
/locus_tag="Rv1820"
/product="Probable acetolactate synthase IlvG
(acetohydroxy-acid synthase)(ALS)"
/note="Rv1820, (MTCY1A11.23c), len: 547 aa. Probable
ilvG,acetolactate synthase. Equivalent to
AL008609|MLCB1788.46c ilvG from Mycobacterium leprae (548
aa) (86.1% identity in 548 aa overlap). Similar to
ILVB_KLEPN|P27696 (559 aa),FASTA scores: opt: 660, E():
2.9e-34, (29.1% identity in 549 aa overlap). Also similar
to other Mycobacterium tuberculosis Ilv proteins e.g.
Rv3003c (ilvB), etc. Contains PS00187 Thiamine
pyrophosphate enzymes signature."
/db_xref="EnsemblGenomes-Gn:Rv1820"
/db_xref="EnsemblGenomes-Tr:CCP44586"
/db_xref="GOA:P9WG39"
/db_xref="InterPro:IPR000399"
/db_xref="InterPro:IPR011766"
/db_xref="InterPro:IPR012000"
/db_xref="InterPro:IPR012001"
/db_xref="InterPro:IPR029035"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/Swiss-Prot:P9WG39"
/inference="protein motif:PROSITE:PS00187"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44586.1"
/translation="MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGC
REEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPL
VVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPS
GVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGT
NVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVG
VPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDH
QGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSY
AGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWD
TLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELV
SVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA"
gene 2066457..2068883
/gene="secA2"
/locus_tag="Rv1821"
CDS 2066457..2068883
/codon_start=1
/transl_table=11
/gene="secA2"
/locus_tag="Rv1821"
/product="Possible preprotein translocase ATPase SecA2"
/note="Rv1821, (MTCY1A11.22c), len: 808 aa. Possible
secA2,preprotein translocase and ATPase, component of
secretion apparatus (see Braunstein & Belisle 2000),
similar to several preprotein translocases e.g.
P28366|SECA_BACSU preprotein translocase secA subunit from
Bacillus subtilis (841 aa), FASTA scores: opt: 1424, E():
0, (35.9% identity in 786 aa overlap). Equivalent to
AL008609|MLCB1788.45 Preprotein translocase SecA 2 from
Mycobacterium leprae (778 aa) (87.1% identity in 780 aa
overlap). Also similar to Rv3240c|MTCY20B11.15c secA
preprotein translocase from Mycobacterium tuberculosis
(949 aa). Could be part of the prokaryotic protein
translocation apparatus which comprise SECA|Rv3240c,
SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c,SECG|Rv1440 and
SECY|Rv0732. Binds ATP."
/db_xref="EnsemblGenomes-Gn:Rv1821"
/db_xref="EnsemblGenomes-Tr:CCP44587"
/db_xref="GOA:P9WGP3"
/db_xref="InterPro:IPR000185"
/db_xref="InterPro:IPR011115"
/db_xref="InterPro:IPR011116"
/db_xref="InterPro:IPR011130"
/db_xref="InterPro:IPR014018"
/db_xref="InterPro:IPR020937"
/db_xref="InterPro:IPR026389"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036266"
/db_xref="InterPro:IPR036670"
/db_xref="PDB:4UAQ"
/db_xref="UniProtKB/Swiss-Prot:P9WGP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44587.1"
/translation="MNVHGCPRIAACRCTDTHPRGRPAFAYRWFVPKTTRAQPGRLSS
RFWRLLGASTEKNRSRSLADVTASAEYDKEAADLSDEKLRKAAGLLNLDDLAESADIP
QFLAIAREAAERRTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAG
RHVHVVTINDYLARRDAEWMGPLLDAMGLTVGWITADSTPDERRTAYDRDVTYASVNE
IGFDVLRDQLVTDVNDLVSPNPDVALIDEADSVLVDEALVPLVLAGTTHRETPRLEII
RLVAELVGDKDADEYFATDSDNRNVHLTEHGARKVEKALGGIDLYSEEHVGTTLTEVN
VALHAHVLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETG
EVLDTITVQALINRYATVCGMTGTALAAGEQLRQFYQLGVSPIPPNKPNIREDEADRV
YITTAAKNDGIVEHITEVHQRGQPVLVGTRDVAESEELHERLVRRGVPAVVLNAKNDA
EEARVIAEAGKYGAVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGTGRHHTE
RLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANLDHNKLPMATDENGRIVSPRTGSLL
DHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVERRNTLLRTVTAREELAELAPKRYE
ELSDKVSEERLETICRQIMLYHLDRGWADHLAYLADIRESIHLRALGRQNPLDEFHRM
AVDAFASLAADAIEAAQQTFETANVLDHEPGLDLSKLARPTSTWTYMVNDNPLSDDTL
SALSLPGVFR"
gene 2069080..2069709
/gene="pgsA2"
/locus_tag="Rv1822"
CDS 2069080..2069709
/codon_start=1
/transl_table=11
/gene="pgsA2"
/locus_tag="Rv1822"
/product="Probable CDP-diacylglycerol--glycerol-3-
phosphate 3-phosphatidyltransferase PgsA2 (PGP synthase)
(phosphatidylglycerophosphate synthase)
(3-phosphatidyl-1'-glycerol-3'phosphate synthase)"
/note="Rv1822, (MTCY1A11.21c), len: 209 aa. Probable
pgsA2,CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyl-transferase (see citation below), integral
membrane protein, equivalent to AL008609|MLCB1788_17
phosphatidyltransferase from Mycobacterium leprae (206
aa),FASTA score: (76.6% identity in 205 aa overlap). Also
highly similar or similar to others e.g.
CAB88885.1|AL353861 putative
CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyl-transferase from Streptomyces coelicolor
(215 aa); AAC44003.1|U29587 phosphatidylglycerol phosphate
synthase from Rhodobacter sphaeroides (227 aa);
NP_405431.1|NC_003143
CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase from Yersinia pestis (182 aa);
P06978|PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase from Escherichia coli (181
aa),FASTA scores: opt: 252, E(): 2.8e-09, (29.7% identity
in 175 aa overlap); etc. Also similar to
Rv2746c|PGSA3|MTV002.11c
CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase (PGP synthase) from
Mycobacterium tuberculosis (209 aa). Contains PS00379
CDP-alcohol phosphatidyltransferases signature; and
PS00075 Dihydrofolate reductase signature. Belongs to the
CDP-alcohol phosphatidyltransferase class-I family."
/db_xref="EnsemblGenomes-Gn:Rv1822"
/db_xref="EnsemblGenomes-Tr:CCP44588"
/db_xref="GOA:P9WPG5"
/db_xref="InterPro:IPR000462"
/db_xref="InterPro:IPR004570"
/db_xref="UniProtKB/Swiss-Prot:P9WPG5"
/inference="protein motif:PROSITE:PS00379"
/inference="protein motif:PROSITE:PS00075"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44588.1"
/translation="MEPVLTQNRVLTVPNMLSVIRLALIPAFVYVVLSAHANGWGVAI
LVFSGVSDWADGKIARLLNQSSRLGALLDPAVDRLYMVTVPIVFGLSGIVPWWFVLTL
LTRDALLAGTLPLLWSRGLSALPVTYVGKAATFGFMVGFPTILLGQCDPLWSHVLLAC
GWAFLIWGMYAYLWAFVLYAVQMTMVVRQMPKLKGRAHRPAAQNAGERG"
gene 2069702..2070625
/locus_tag="Rv1823"
CDS 2069702..2070625
/codon_start=1
/transl_table=11
/locus_tag="Rv1823"
/product="Conserved protein"
/note="Rv1823, (MTCY01A11.20), len: 307 aa. Conserved
protein, similar to P71582|MTCY10H4.12|RV0012 hypothetical
protein CY10H4.12 from Mycobacterium tuberculosis (262
aa),FASTA scores: opt: 304, E(): 1.5e-12, (30.1% identity
in 246 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1823"
/db_xref="EnsemblGenomes-Tr:CCP44589"
/db_xref="GOA:P9WFG1"
/db_xref="InterPro:IPR010273"
/db_xref="UniProtKB/Swiss-Prot:P9WFG1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44589.1"
/translation="MAESDRLLGGYDPNAGYSAHAGAQPQRIPVPSLLRALLSEHLDA
GYAAVAAERERAAAPRCWQARAVSWMWQALAATLVAAVFAAAVAQARSVAPGVRAAQQ
LLVASVRSTQAAATTLAQRRSTLSAKVDDVRRIVLADDAEGQRLLARLDVLSLAAASA
PVVGPGLTVTVTDPGASPNLSDVSKQRVSGSQQIILDRDLQLVVNSLWESGAEAISID
GVRIGPNVTIRQAGGAILVDNNPTSSPYTILAVGPPHAMQDVFDRSAGLYRLRLLETS
YGVGVSVNVGDGLALPAGATRDVKFAKQIGP"
gene 2070654..2071019
/locus_tag="Rv1824"
CDS 2070654..2071019
/codon_start=1
/transl_table=11
/locus_tag="Rv1824"
/product="Conserved hypothetical membrane protein"
/note="Rv1824, (MTCY1A11.19c), len: 121 aa. Conserved
hypothetical membrane protein similar to P28265|SBP_BACSU
sbp protein from Bacillus subtilis (121 aa), FASTA scores:
opt: 261, E(): 1.9e-12, (38.9% identity in 113 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1824"
/db_xref="EnsemblGenomes-Tr:CCP44590"
/db_xref="GOA:P9WLR7"
/db_xref="InterPro:IPR009709"
/db_xref="UniProtKB/Swiss-Prot:P9WLR7"
/protein_id="CCP44590.1"
/translation="MGSDTAWSPARMIGIAALAVGIVLGLVFHPGVPEVIQPYLPIAV
VAALDAVFGGLRAYLERIFDPKVFVVSFVFNVLVAALIVYVGDQLGVGTQLSTAIIVV
LGIRIFGNTAALRRRLFGA"
gene 2071036..2071914
/locus_tag="Rv1825"
CDS 2071036..2071914
/codon_start=1
/transl_table=11
/locus_tag="Rv1825"
/product="Conserved protein"
/note="Rv1825, (MTCY1A11.18c), len: 292 aa. Conserved
protein, weak similarity to Mycobacterium tuberculosis
hypothetical proteins Q50610|MTCY1A11.20C|Rv1823|Z78020
(307 aa), FASTA scores: opt: 182, E(): 0.00044, (29.9%
identity in 204 aa overlap); and Rv0012. Has a hydrophobic
stretch, TMhelix from aa 67 to 85."
/db_xref="EnsemblGenomes-Gn:Rv1825"
/db_xref="EnsemblGenomes-Tr:CCP44591"
/db_xref="GOA:P9WFG3"
/db_xref="InterPro:IPR010273"
/db_xref="PDB:3GMG"
/db_xref="UniProtKB/Swiss-Prot:P9WFG3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44591.1"
/translation="MSENRPEPVAAETSAATTARHSQADAGAHDAVRRGRHELPADHP
RSKVGPLRRTRLTEILRGGRSRLVFGTLAILLCLVLGVAIVTQVRQTDSGDSLETARP
ADLLVLLDSLRQREATLNAEVIDLQNTLNALQASGNTDQAALESAQARLAALSILVGA
VGATGPGVMITIDDPGPGVAPEVMIDVINELRAAGAEAIQINDAHRSVRVGVDTWVVG
VPGSLTVDTKVLSPPYSILAIGDPPTLAAAMNIPGGAQDGVKRVGGRMVVQQADRVDV
TALRQPKQHQYAQPVK"
gene 2071952..2072356
/gene="gcvH"
/locus_tag="Rv1826"
CDS 2071952..2072356
/codon_start=1
/transl_table=11
/gene="gcvH"
/locus_tag="Rv1826"
/product="Probable glycine cleavage system H protein GcvH"
/note="Rv1826, (MTCY1A11.17c), len: 134 aa. Probable
gcvH,glycine cleavage system H protein, highly similar to
GCSH_ECOLI|P23884 glycine cleavage system H protein from
Escherichia coli (129 aa), FASTA scores: opt: 428, E():
2.2e-22, (47.8% identity in 134 aa overlap). Equivalent to
MLCB1788.37c gcvH from Mycobacterium leprae (78.4%
identity in 134 aa overlap). Contains PS00189 2-oxo acid
dehydrogenases acyltransferase component lipoyl binding
site. Belongs to the GcvH family."
/db_xref="EnsemblGenomes-Gn:Rv1826"
/db_xref="EnsemblGenomes-Tr:CCP44592"
/db_xref="GOA:P9WN55"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR002930"
/db_xref="InterPro:IPR003016"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR017453"
/db_xref="InterPro:IPR033753"
/db_xref="PDB:3HGB"
/db_xref="PDB:3IFT"
/db_xref="PDB:5EXK"
/db_xref="UniProtKB/Swiss-Prot:P9WN55"
/inference="protein motif:PROSITE:PS00189"
/protein_id="CCP44592.1"
/translation="MSDIPSDLHYTAEHEWIRRSGDDTVRVGITDYAQSALGDVVFVQ
LPVIGTAVTAGETFGEVESTKSVSDLYAPISGKVSEVNSDLDGTPQLVNSDPYGAGWL
LDIQVDSSDVAALESALTTLLDAEAYRGTLTE"
gene 2072596..2073084
/gene="garA"
/gene_synonym="cfp17"
/locus_tag="Rv1827"
CDS 2072596..2073084
/codon_start=1
/transl_table=11
/gene="garA"
/gene_synonym="cfp17"
/locus_tag="Rv1827"
/product="Conserved protein with FHA domain, GarA"
/note="Rv1827, (MTCY1A11.16c), len: 162 aa. GarA,
conserved protein with forkhead-associated domain at
C-terminus (see citation below), equivalent to
O32919|MLCB1788.36c hypothetical protein from
Mycobacterium leprae (162 aa),FASTA scores: opt: 888, E():
0, (87.0% identity in 161 aa overlap). Putative
physiological substrate of PknB and PknG."
/db_xref="EnsemblGenomes-Gn:Rv1827"
/db_xref="EnsemblGenomes-Tr:CCP44593"
/db_xref="GOA:P9WJA9"
/db_xref="InterPro:IPR000253"
/db_xref="InterPro:IPR008984"
/db_xref="PDB:2KFU"
/db_xref="PDB:6I2P"
/db_xref="UniProtKB/Swiss-Prot:P9WJA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44593.1"
/translation="MTDMNPDIEKDQTSDEVTVETTSVFRADFLSELDAPAQAGTESA
VSGVEGLPPGSALLVVKRGPNAGSRFLLDQAITSAGRHPDSDIFLDDVTVSRRHAEFR
LENNEFNVVDVGSLNGTYVNREPVDSAVLANGDEVQIGKFRLVFLTGPKQGEDDGSTG
GP"
gene 2073081..2073824
/locus_tag="Rv1828"
CDS 2073081..2073824
/codon_start=1
/transl_table=11
/locus_tag="Rv1828"
/product="Conserved protein"
/note="Rv1828, (MTCY1A11.15c), len: 247 aa. Conserved
protein, equivalent to O32918|MLCB1788.35c|AL008609
hypothetical protein from Mycobacterium leprae (251
aa),FASTA scores: opt: 1397, E(): 0, (87.6% identity in
251 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1828"
/db_xref="EnsemblGenomes-Tr:CCP44594"
/db_xref="GOA:P9WME7"
/db_xref="InterPro:IPR000551"
/db_xref="InterPro:IPR009061"
/db_xref="PDB:5YDC"
/db_xref="PDB:5YDD"
/db_xref="UniProtKB/Swiss-Prot:P9WME7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44594.1"
/translation="MSAPDSPALAGMSIGAVLDLLRPDFPDVTISKIRFLEAEGLVTP
RRASSGYRRFTAYDCARLRFILTAQRDHYLPLKVIRAQLDAQPDGELPPFGSPYVLPR
LVPVAGDSAGGVGSDTASVSLTGIRLSREDLLERSEVADELLTALLKAGVITTGPGGF
FDEHAVVILQCARALAEYGVEPRHLRAFRSAADRQSDLIAQIAGPLVKAGKAGARDRA
DDLAREVAALAITLHTSLIKSAVRDVLHR"
gene 2073943..2074437
/locus_tag="Rv1829"
CDS 2073943..2074437
/codon_start=1
/transl_table=11
/locus_tag="Rv1829"
/product="Conserved protein"
/note="Rv1829, (MTCY1A11.14c), len: 164 aa. Conserved
protein, equivalent to O32917|MLCB1788.34|AL008609
Hypothetical protein from Mycobacterium leprae (164
aa),FASTA scores: opt: 1011, E(): 0, (95.1% identity in
164 aa overlap). Also present in Aquifex aeolicus, etc."
/db_xref="EnsemblGenomes-Gn:Rv1829"
/db_xref="EnsemblGenomes-Tr:CCP44595"
/db_xref="GOA:P9WLR5"
/db_xref="InterPro:IPR003729"
/db_xref="InterPro:IPR036104"
/db_xref="UniProtKB/Swiss-Prot:P9WLR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44595.1"
/translation="MGEVRVVGIRVEQPQNQPVLLLREANGDRYLPIWIGQSEAAAIA
LEQQGVEPPRPLTHDLIRDLIAALGHSLKEVRIVDLQEGTFYADLIFDRNIKVSARPS
DSVAIALRVGVPIYVEEAVLAQAGLLIPDESDEEATTAVREDEVEKFKEFLDSVSPDD
FKAT"
gene 2074841..2075518
/locus_tag="Rv1830"
CDS 2074841..2075518
/codon_start=1
/transl_table=11
/locus_tag="Rv1830"
/product="Conserved hypothetical protein"
/note="Rv1830, (MTCY1A11.13c), len: 225 aa. Conserved
hypothetical protein, equivalent to Mycobacterium leprae
hypothetical protein MLCB1788.33c|AL008609|O32916 (231
aa),FASTA scores: opt: 1307, E(): 0, (89.6% identity in
231 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1830"
/db_xref="EnsemblGenomes-Tr:CCP44596"
/db_xref="GOA:P9WME5"
/db_xref="InterPro:IPR000551"
/db_xref="InterPro:IPR009061"
/db_xref="UniProtKB/Swiss-Prot:P9WME5"
/protein_id="CCP44596.1"
/translation="MTQLVTRARSARGSTLGEQPRQDQLDFADHTGTAGDGNDGAAAA
SGPVQPGLFPDDSVPDELVGYRGPSACQIAGITYRQLDYWARTSLVVPSIRSAAGSGS
QRLYSFKDILVLKIVKRLLDTGISLHNIRVAVDHLRQRGVQDLANITLFSDGTTVYEC
TSAEEVVDLLQGGQGVFGIAVSGAMRELTGVIADFHGERADGGESIAAPEDELASRRK
HRDRKIG"
gene 2075571..2075828
/locus_tag="Rv1831"
CDS 2075571..2075828
/codon_start=1
/transl_table=11
/locus_tag="Rv1831"
/product="Hypothetical protein"
/note="Rv1831, (MTCY1A11.12c), len: 85 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1831"
/db_xref="EnsemblGenomes-Tr:CCP44597"
/db_xref="UniProtKB/Swiss-Prot:P9WLR3"
/protein_id="CCP44597.1"
/translation="MRLCVCSAVDWTTHRSSAGEFCGCQLRTPKEQYLSVNLSGTRTA
RDYDASGKRWRPLAVLTRRWGKAIHLTVDRVAESLRRLACR"
gene 2075877..2078702
/gene="gcvB"
/locus_tag="Rv1832"
CDS 2075877..2078702
/codon_start=1
/transl_table=11
/gene="gcvB"
/locus_tag="Rv1832"
/product="Probable glycine dehydrogenase GcvB (glycine
decarboxylase) (glycine cleavage system P-protein)"
/note="Rv1832, (MTCY1A11.11c), len: 941 aa. Probable
gcvB,glycine dehydrogenase [decarboxylating], highly
similar to GCSP_ECOLI|P33195 glycine dehydrogenase
(decarboxylating) from Escherichia coli (957 aa), FASTA
scores: opt: 2194,E(): 0, (55.4% identity in 961 aa
overlap). The glycine cleavage system is composed of four
proteins: P, T, L, and H"
/db_xref="EnsemblGenomes-Gn:Rv1832"
/db_xref="EnsemblGenomes-Tr:CCP44598"
/db_xref="GOA:P9WN53"
/db_xref="InterPro:IPR003437"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR020581"
/db_xref="UniProtKB/Swiss-Prot:P9WN53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44598.1"
/translation="MSDHSTFADRHIGLDSQAVATMLAVIGVDSLDDLAVKAVPAGIL
DTLTDTGAAPGLDSLPPAASEAEALAELRALADANTVAVSMIGQGYYDTHTPPVLLRN
IIENPAWYTAYTPYQPEISQGRLEALLNFQTLVTDLTGLEIANASMLDEGTAAAEAMT
LMHRAARGPVKRVVVDADVFTQTAAVLATRAKPLGIEIVTADLRAGLPDGEFFGVIAQ
LPGASGRITDWSALVQQAHDRGALVAVGADLLALTLIAPPGEIGADVAFGTTQRFGVP
MGFGGPHAGYLAVHAKHARQLPGRLVGVSVDSDGTPAYRLALQTREQHIRRDKATSNI
CTAQVLLAVLAAMYASYHGAGGLTAIARRVHAHAEAIAGALGDALVHDKYFDTVLARV
PGRADEVLARAKANGINLWRVDADHVSVACDEATTDTHVAVVLDAFGVAAAAPAHTDI
ATRTSEFLTHPAFTQYRTETSMMRYLRALADKDIALDRSMIPLGSCTMKLNAAAEMES
ITWPEFGRQHPFAPASDTAGLRQLVADLQSWLVLITGYDAVSLQPNAGSQGEYAGLLA
IHEYHASRGEPHRDICLIPSSAHGTNAASAALAGMRVVVVDCHDNGDVDLDDLRAKVG
EHAERLSALMITYPSTHGVYEHDIAEICAAVHDAGGQVYVDGANLNALVGLARPGKFG
GDVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLAPFLPGHPFAPELPKGYPVSSAPYGS
ASILPITWAYIRMMGAEGLRAASLTAITSANYIARRLDEYYPVLYTGENGMVAHECIL
DLRGITKLTGITVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESESLAEVDAFCEAM
IGIRAEIDKVGAGEWPVDDNPLRGAPHTAQCLLASDWDHPYTREQAAYPLGTAFRPKV
WPAVRRIDGAYGDRNLVCSCPPVEAFA"
gene complement(2078929..2079789)
/locus_tag="Rv1833c"
CDS complement(2078929..2079789)
/codon_start=1
/transl_table=11
/locus_tag="Rv1833c"
/product="Possible haloalkane dehalogenase"
/note="Rv1833c, (MTCY1A11.10), len: 286 aa. Possible
haloalkane dehalogenase. Similar to several haloalkane
dehalogenase e.g. CAB45532.1|AJ243259 from Mycobacterium
bovis (300 aa); also similar to LINB_PSEPA|P51698
1,3,4,6-tetrachloro-1,4-cyclohexadien from Pseudomonas
paucimobilis (295 aa), FASTA scores: opt: 314, E():
1.5e-13, (33.1% identity in 281 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1833c"
/db_xref="EnsemblGenomes-Tr:CCP44599"
/db_xref="GOA:P9WMS1"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR023489"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WMS1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44599.1"
/translation="MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTGPPILLCHGNP
TWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDR
YLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAI
LRRNFFVERLIPAGTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLA
REVPATLGTKPTLLIWGMKDVAFRPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDR
IAAAIIERFG"
gene 2079830..2080696
/gene="lipZ"
/locus_tag="Rv1834"
CDS 2079830..2080696
/codon_start=1
/transl_table=11
/gene="lipZ"
/locus_tag="Rv1834"
/product="Probable hydrolase"
/note="Rv1834, (MTCY1A11.09c), len: 288 aa. Probable
lipZ,hydrolase, some similarity to haloalkane
dehalogenases and D16262 hypothetical 38.9 kDa protein
(335 aa), FASTA scores: opt: 507, E(): 7.6e-28, (33.0%
identity in 300 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1834"
/db_xref="EnsemblGenomes-Tr:CCP44600"
/db_xref="GOA:P9WLR1"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WLR1"
/protein_id="CCP44600.1"
/translation="MTSPSVREWRDGGRWLPTAVGKVFVRSGPGDTPTMLLLHGYPSS
SFDFRAVIPHLTGQAWVTMDFLGFGLSDKPRPHRYSLLEQAHLVETVVAHTVTGAVVV
LAHDMGTSVTTELLARDLDGRLPFDLRRAVLSNGSVILERASLRPIQKVLRSPLGPVA
ARLVSRGGFTRGFGRIFSPAHPLSAQEAQAQWELLCYNDGNRIPHLLISYLDERIRHA
QRWHGAVRDWPKPLGFVWGLDDPVATTNVLNGLRELRPSAAVVELPGLGHYPQVEAPK
AYAEAALSLLVD"
gene complement(2080701..2082587)
/locus_tag="Rv1835c"
CDS complement(2080701..2082587)
/codon_start=1
/transl_table=11
/locus_tag="Rv1835c"
/product="Conserved hypothetical protein"
/note="Rv1835c, (MTCY1A11.08), len: 628 aa. Conserved
hypothetical protein, some similarity to putative acylases
e.g. G216374 glutaryl 7-aca acylase precursor (634 aa)
FASTA scores, opt: 202, E(): 3.5e-06, (25.1% identity in
669 aa overlap). Also similar to Mycobacterium
tuberculosis hypothetical proteins Rv2800 and Rv1215c."
/db_xref="EnsemblGenomes-Gn:Rv1835c"
/db_xref="EnsemblGenomes-Tr:CCP44601"
/db_xref="GOA:P9WIQ9"
/db_xref="InterPro:IPR000383"
/db_xref="InterPro:IPR005674"
/db_xref="InterPro:IPR008979"
/db_xref="InterPro:IPR013736"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WIQ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44601.1"
/translation="MTRRGGSDAAWYSAPDQRSAYPRYRGMRYSSCYVTMRDGVRIAI
DLYLPAGLTSAARLPAILHQTRYYRSLQLRWPLRMLLGGKPLQHIAADKRRRRRFVAS
GYAWVDVDVRGSGASFGARVCEWSSDEIRDGAEIVDWIVRQPWCNGTVAALGNSYDGT
SAELLLVNQHPAVRVIAPCFSLFDVYTDIAFPGGIHAAWFTDTWGRYNEALDRNALHE
VVGWWAKLPVTGMQPVQEDRDRSLRDGAIAAHRGNYDVHQIAGSLTFRDDVSASDPYR
GQPDARLEPIGTPIESGSINLISPHNYWRDVQASGAAIYSYSGWFDGGYAHAAIKRFL
TVSTPGSHLILGPWNHTGGWRVDPLRGLSRPDFDHDGELLRFIDHHVKGADTGIGSEP
PVHYFTMVENRWKSADTWPPPATTQSYYLSADRQLRPDAPDCDSGADEYVVDQTAGTG
ERSRWRSQVGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLEVTGHVVVTLFITSTSSDG
TFFVYLEDVDPRGRVAYITEGQLRAIHRRLSDGPPPYRQVVPYRTFASGDAWPLVPGE
IARLTFDLLPTSYLFQPGHRIRIAIAGADASHFAILPGCAPTVRVYRSRMHASRIDLP
VIQP"
gene complement(2082603..2084636)
/locus_tag="Rv1836c"
CDS complement(2082603..2084636)
/codon_start=1
/transl_table=11
/locus_tag="Rv1836c"
/product="Conserved protein"
/note="Rv1836c, (MTCY1A11.07), len: 677 aa. Conserved
protein. Equivalent to MLCB1788.28|AL008609 hypothetical
protein from Mycobacterium leprae (710 aa), FASTA scores:
opt: 2938, E(): 0, (66.0% identity in 714 aa overlap).
Contains PS00036 bZIP transcription factors basic domain
signature. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1836c"
/db_xref="EnsemblGenomes-Tr:CCP44602"
/db_xref="GOA:P9WLQ9"
/db_xref="InterPro:IPR002035"
/db_xref="InterPro:IPR036465"
/db_xref="UniProtKB/Swiss-Prot:P9WLQ9"
/inference="protein motif:PROSITE:PS00036"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44602.1"
/translation="MGRHSKPDPEDSVDDLSDGHAAEQQHWEDISGSYDYPGVDQPDD
GPLSSEGHYSAVGGYSASGSEDYPDIPPRPDWEPTGAEPIAAAPPPLFRFGHRGPGDW
QAGHRSADGRRGVSIGVIVALVAVVVMVAGVILWRFFGDALSNRSHTAAARCVGGKDT
VAVIADPSIADQVKESADSYNASAGPVGDRCVAVAVTSAGSDAVINGFIGKWPTELGG
QPGLWIPSSSISAARLTGAAGSQAISDSRSLVISPVLLAVRPELQQALANQNWAALPG
LQTNPNSLSGLDLPAWGSLRLAMPSSGNGDAAYLAGEAVAAASAPAGAPATAGIGAVR
TLMGARPKLADDSLTAAMDTLLKPGDVATAPVHAVVTTEQQLFQRGQSLSDAENTLGS
WLPPGPAAVADYPTVLLSGAWLSQEQTSAASAFARYLHKPEQLAKLARAGFRVSDVKP
PSSPVTSFPALPSTLSVGDDSMRATLADTMVTASAGVAATIMLDQSMPNDEGGNSRLS
NVVAALENRIKAMPPSSVVGLWTFDGREGRTEVPAGPLADPVNGQPRPAALTAALGKQ
YSSGGGAVSFTTLRLIYQEMLANYRVGQANSVLVITAGPHTDQTLDGPGLQDFIRKSA
DPAKPIAVNIIDFGADPDRATWEAVAQLSGGSYQNLETSASPDLATAVNIFLS"
gene complement(2084756..2086981)
/gene="glcB"
/locus_tag="Rv1837c"
CDS complement(2084756..2086981)
/codon_start=1
/transl_table=11
/gene="glcB"
/locus_tag="Rv1837c"
/product="Malate synthase G GlcB"
/note="Rv1837c, (MTCY1A11.06), len: 741 aa. glcB, malate
synthase G (see citations below), highly similar to
MASY_CORGL|P42450 malate synthase (738 aa), FASTA score:
opt: 2961, E(): 0, (61.3% identity in 724 aa overlap).
Belongs to the malate synthase G family."
/db_xref="EnsemblGenomes-Gn:Rv1837c"
/db_xref="EnsemblGenomes-Tr:CCP44603"
/db_xref="GOA:P9WK17"
/db_xref="InterPro:IPR001465"
/db_xref="InterPro:IPR006253"
/db_xref="InterPro:IPR011076"
/db_xref="InterPro:IPR023310"
/db_xref="PDB:2GQ3"
/db_xref="PDB:3S9I"
/db_xref="PDB:3S9Z"
/db_xref="PDB:3SAD"
/db_xref="PDB:3SAZ"
/db_xref="PDB:3SB0"
/db_xref="PDB:5C7V"
/db_xref="PDB:5C9R"
/db_xref="PDB:5C9U"
/db_xref="PDB:5C9W"
/db_xref="PDB:5C9X"
/db_xref="PDB:5CAH"
/db_xref="PDB:5CAK"
/db_xref="PDB:5CBB"
/db_xref="PDB:5CBI"
/db_xref="PDB:5CBJ"
/db_xref="PDB:5CC3"
/db_xref="PDB:5CC5"
/db_xref="PDB:5CC6"
/db_xref="PDB:5CC7"
/db_xref="PDB:5CCZ"
/db_xref="PDB:5CEW"
/db_xref="PDB:5CJM"
/db_xref="PDB:5CJN"
/db_xref="PDB:5DRC"
/db_xref="PDB:5DRI"
/db_xref="PDB:5DX7"
/db_xref="PDB:5E9X"
/db_xref="PDB:5ECV"
/db_xref="PDB:5H8M"
/db_xref="PDB:5H8P"
/db_xref="PDB:5H8U"
/db_xref="PDB:5T8G"
/db_xref="PDB:6AS6"
/db_xref="PDB:6ASU"
/db_xref="PDB:6AU9"
/db_xref="PDB:6AXB"
/db_xref="PDB:6BA7"
/db_xref="PDB:6BU1"
/db_xref="PDB:6C2X"
/db_xref="PDB:6C6O"
/db_xref="PDB:6C7B"
/db_xref="PDB:6C8P"
/db_xref="PDB:6DKO"
/db_xref="PDB:6DL9"
/db_xref="PDB:6DLJ"
/db_xref="PDB:6DNP"
/db_xref="UniProtKB/Swiss-Prot:P9WK17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44603.1"
/translation="MTDRVSVGNLRIARVLYDFVNNEALPGTDIDPDSFWAGVDKVVA
DLTPQNQALLNARDELQAQIDKWHRRRVIEPIDMDAYRQFLTEIGYLLPEPDDFTITT
SGVDAEITTTAGPQLVVPVLNARFALNAANARWGSLYDALYGTDVIPETDGAEKGPTY
NKVRGDKVIAYARKFLDDSVPLSSGSFGDATGFTVQDGQLVVALPDKSTGLANPGQFA
GYTGAAESPTSVLLINHGLHIEILIDPESQVGTTDRAGVKDVILESAITTIMDFEDSV
AAVDAADKVLGYRNWLGLNKGDLAAAVDKDGTAFLRVLNRDRNYTAPGGGQFTLPGRS
LMFVRNVGHLMTNDAIVDTDGSEVFEGIMDALFTGLIAIHGLKASDVNGPLINSRTGS
IYIVKPKMHGPAEVAFTCELFSRVEDVLGLPQNTMKIGIMDEERRTTVNLKACIKAAA
DRVVFINTGFLDRTGDEIHTSMEAGPMVRKGTMKSQPWILAYEDHNVDAGLAAGFSGR
AQVGKGMWTMTELMADMVETKIAQPRAGASTAWVPSPTAATLHALHYHQVDVAAVQQG
LAGKRRATIEQLLTIPLAKELAWAPDEIREEVDNNCQSILGYVVRWVDQGVGCSKVPD
IHDVALMEDRATLRISSQLLANWLRHGVITSADVRASLERMAPLVDRQNAGDVAYRPM
APNFDDSIAFLAAQELILSGAQQPNGYTEPILHRRRREFKARAAEKPAPSDRAGDDAA
R"
gene complement(2087257..2087652)
/gene="vapC13"
/locus_tag="Rv1838c"
CDS complement(2087257..2087652)
/codon_start=1
/transl_table=11
/gene="vapC13"
/locus_tag="Rv1838c"
/product="Possible toxin VapC13"
/note="Rv1838c, (MTCY359.35), len: 131 aa. Possible
vapC13,toxin, part of toxin-antitoxin (TA) operon with
Rv1839c,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Part of 14-membered
Mycobacterium tuberculosis protein family with
Rv2863|MTV003.09|AL008883 (126 aa), FASTA scores: opt:
293, E(): 1.5e-14, (38.2% identity in 123 aa overlap);
Rv0749, Rv0277c, Rv2530c, etc. Also similar to
AJ248288|CNSPAX06_181 Pyrococcus abyssi complete genome
(136 aa), FASTA scores: opt: 197, E(): 2.2e-07, (33. 1%
identity in 133 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1838c"
/db_xref="EnsemblGenomes-Tr:CCP44604"
/db_xref="GOA:P9WFA1"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WFA1"
/protein_id="CCP44604.1"
/translation="MILVDSNIPMYLVGASHPHKLDAQRLLESALSGGERLVTDAEVL
QEICHRYVAIKRREAIQPAFDAIIGVVDEVLPIERTDVEHARDALLRYQTLSARDALH
IAVMAHHDITRLMSFDRGFDSYPGIKRLA"
gene complement(2087649..2087912)
/gene="vapB13"
/locus_tag="Rv1839c"
CDS complement(2087649..2087912)
/codon_start=1
/transl_table=11
/gene="vapB13"
/locus_tag="Rv1839c"
/product="Possible antitoxin VapB13"
/note="Rv1839c, (MTCY359.34), len: 87 aa. Possible
vapB13,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1838c (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Some similarity to others in M. tuberculosis e.g.
Rv0239,Rv0662c"
/db_xref="EnsemblGenomes-Gn:Rv1839c"
/db_xref="EnsemblGenomes-Tr:CCP44605"
/db_xref="UniProtKB/Swiss-Prot:P9WJ51"
/protein_id="CCP44605.1"
/translation="MSKRLQVLLDPDEWEELREIARRHRTTVSEWVRRTLREAREREP
RGDLDMKLRSVRAAARHEFPTADVEQMLEEIERGRGAEREGSR"
gene complement(2087971..2089518)
/gene="PE_PGRS34"
/locus_tag="Rv1840c"
CDS complement(2087971..2089518)
/codon_start=1
/transl_table=11
/gene="PE_PGRS34"
/locus_tag="Rv1840c"
/product="PE-PGRS family protein PE_PGRS34"
/note="Rv1840c, (MTCY359.33), len: 515 aa.
PE_PGRS34,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below). Similar to many e.g. Y03A_MYCTU|Q10637
hypothetical glycine-rich 49.6 kDa protein (603 aa), FASTA
scores: opt: 1693, E(): 0, (53.1% identity in 612 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1840c"
/db_xref="EnsemblGenomes-Tr:CCP44606"
/db_xref="GOA:P9WIF3"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIF3"
/protein_id="CCP44606.1"
/translation="MSFVVAAPEVVVAAASDLAGIGSAIGAANAAAAVPTMGVLAAGA
DEVSAAVADLFGAHAQAYQALSAQAALFHEQFVHAMTAGAGAYAGAEAADAAALDVLN
GPFQALFGRPLIGDGANGAPGQPGGPGGLLYGNGGNGGNGGIGQPGGAGGDAGLIGNG
GNGGIGGPGATGLAGGAGGVGGLLFGDGGNGGAGGLGTGPVGATGGIGGPGGAAVGLF
GHGGAGGAGGLGKAGFAGGAGGTGGTGGLLYGNGGNGGNVPSGAADGGAGGDARLIGN
GGDGGSVGAAPTGIGNGGNGGNGGWLYGDGGSGGSTLQGFSDGGTGGNAGMFGDGGNG
GFSFFDGNGGDGGTGGTLIGNGGDGGNSVQTDGFLRGHGGDGGNAVGLIGNGGAGGAG
SAGTGVFAPGGGSGGNGGNGALLVGNGGAGGSGGPTQIPSVAVPVTGAGGTGGNGGTA
GLIGNGGNGGAAGVSGDGTPGTGGNGGYAQLIGDGGDGGPGDSGGPGGSGGTGGTLAG
QNGSPGG"
gene complement(2089681..2090718)
/locus_tag="Rv1841c"
CDS complement(2089681..2090718)
/codon_start=1
/transl_table=11
/locus_tag="Rv1841c"
/product="Conserved hypothetical membrane protein"
/note="Rv1841c, (MTCY359.32), len: 345 aa. Conserved
hypothetical membrane protein. Some similarity to
O07585|YHDP_BACSU hypothetical 49.9 kDa protein from
Bacillus subtilis (444 aa), FASTA scores: opt: 620, E():
0,(31.1% identity in 350 aa overlap). Also similar to
other Mycobacterium tuberculosis proteins e.g. Rv1842c,
Rv2366c."
/db_xref="EnsemblGenomes-Gn:Rv1841c"
/db_xref="EnsemblGenomes-Tr:CCP44607"
/db_xref="GOA:P9WLQ7"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR002550"
/db_xref="UniProtKB/Swiss-Prot:P9WLQ7"
/protein_id="CCP44607.1"
/translation="MDVLSAVLLALLLIGANAFFVGAEFALISARRDRLEALAEQGKA
TAVTVIRAGEQLPAMLTGAQLGVTVSSILLGRVGEPAVVKLLQLSFGLSGVPPALLHT
LSLAIVVALHVLLGEMVPKNIALAGPERTAMLLVPPYLVYVRLARPFIAFYNNCANAI
LRLVGVQPKDELDIAVSTAELSEMIAESLSEGLLDHEEHTRLTRALRIRTRLVADVAV
PLVNIRAVQVSAVGSGPTIGGVEQALAQTGYSRFPVVDRGGRFIGYLHIKDVLTLGDN
PQTVIDLAVVRPLPRVPQSLPLADALSRMRRINSHLALVTADNGSVVGMVALEDVVED
LVGTMRDGTHR"
gene complement(2090718..2092085)
/locus_tag="Rv1842c"
CDS complement(2090718..2092085)
/codon_start=1
/transl_table=11
/locus_tag="Rv1842c"
/product="Conserved hypothetical membrane protein"
/note="Rv1842c, (MTCY359.31), len: 455 aa. Conserved
hypothetical membrane protein. Similar to Z99109|0O7589
Potential integral membrane protein from Bacillus subtilis
(461 aa), FASTA scores: opt: 723, E(): 0, (31.2% identity
in 449 aa overlap). Similar to other Mycobacterium
tuberculosis putative integral membrane proteins e.g.
Rv2366c, Rv1841c."
/db_xref="EnsemblGenomes-Gn:Rv1842c"
/db_xref="EnsemblGenomes-Tr:CCP44608"
/db_xref="GOA:P9WFP3"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR002550"
/db_xref="InterPro:IPR005170"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/Swiss-Prot:P9WFP3"
/protein_id="CCP44608.1"
/translation="MNLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARG
GTSRDRFIQRAHHRLSFQLSGAQLGISITTLATGYLTEPLVAELPHPGLVAVGMSDRV
ADGLITFFALVIVTSLSMVFGELVPKYLAVARPLRTARSVVAGQVLFSLLLTPAIRLT
NGAANWIVRRLGIEPAEELRSARTPQELVSLVRSSARSGALDDATAWLMRRSLQFGAL
TAEELMTPRSKIVALQTDDTIADLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEV
PPGDRAHTLLTTVAEPVAVVPSTLDGDAVMAQVRASALQTAMVVDEYGGTAGMVTLED
LIEEIVGDVRDEHDDATPDVVAAGNGWRVSGLLRIDEVASATGYRAPDGPYETIGGLV
LRELGHIPVAGETVELTALDQDGLPDDSMRWLATVIQMDGRRIDLLELIKMGGHADPG
SGRGR"
gene complement(2092259..2093698)
/gene="guaB1"
/locus_tag="Rv1843c"
CDS complement(2092259..2093698)
/codon_start=1
/transl_table=11
/gene="guaB1"
/locus_tag="Rv1843c"
/product="Probable inosine-5'-monophosphate dehydrogenase
GuaB1(imp dehydrogenase) (IMPDH) (IMPD)"
/note="Rv1843c, (MTCY359.30), len: 479 aa. Probable
guaB1,inosine-5'-monophosphate dehydrogenase. Similar to
others e.g. IMDH_BACSU|P21879 from Bacillus subtilis (513
aa),FASTA score: opt: 904, E(): 0, (37.8% identity in 471
aa overlap). Similar to other Mycobacterium tuberculosis
proteins e.g. guaB2, Rv3411c."
/db_xref="EnsemblGenomes-Gn:Rv1843c"
/db_xref="EnsemblGenomes-Tr:CCP44609"
/db_xref="GOA:P9WKI3"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR001093"
/db_xref="InterPro:IPR005990"
/db_xref="InterPro:IPR005991"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/Swiss-Prot:P9WKI3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44609.1"
/translation="MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGT
TIPVVVANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTPVT
LAPDDSVSDAMALIHKRAHGVAVVILEGRPIGLVRESSCLGVDRFTRVRDIAVTDYVT
APAGTEPRKIFDLLEHAPVDVAVLTDADGTLAGVLSRTGAIRAGIYTPATDSAGRLRI
GAAVGINGDVGAKARALAEAGVDVLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNV
VSAEGTRDLLKAGANVVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIW
ADGGIRHPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRA
VVARTGADNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVGAS
NLAELHERAVVGVQSGAGFAEGHPLPAGW"
gene complement(2093731..2095188)
/gene="gnd1"
/locus_tag="Rv1844c"
CDS complement(2093731..2095188)
/codon_start=1
/transl_table=11
/gene="gnd1"
/locus_tag="Rv1844c"
/product="Probable 6-phosphogluconate dehydrogenase Gnd1"
/note="Rv1844c, (MTCY359.29), len: 485 aa. Probable
gnd1,6-phosphogluconate dehydrogenase. Similar to others
e.g. 6PGD_ECOLI|P00350 from Escherichia coli (468 aa),
FASTA scores: opt: 1661, E(): 0, (53.6% identity in 466 aa
overlap); etc. Also similar to Rv1122|MTCY22G8.11|gnd2
probable 6-phosphogluconate dehydrogenase, decarboxylating
from Mycobacterium tuberculosis (340 aa), FASTA score:
(33.0% identity in 351 aa overlap). Note that Rv1844c is
most similar to gnd's from Gram negative organisms, while
Rv1122|MTCY22G8.11|gnd2 is most similar to gnd's from Gram
positive organisms. Belongs to the 6-phosphogluconate
dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv1844c"
/db_xref="EnsemblGenomes-Tr:CCP44610"
/db_xref="GOA:Q79FJ2"
/db_xref="InterPro:IPR006113"
/db_xref="InterPro:IPR006114"
/db_xref="InterPro:IPR006115"
/db_xref="InterPro:IPR006183"
/db_xref="InterPro:IPR006184"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:Q79FJ2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44610.1"
/translation="MSSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVA
KTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLIMVKAGEATDADAVINELADAME
PGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQ
SLGPLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLG
LTAPAIADVFTEWNNGDLDSYLVEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWT
VKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQPADPATFTEDVRQA
LYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASP
NLASLIVAPYFRGAVESAIDSWRRVVSTAAQLGIPTPGFSSALSYYDALRTARLPAAL
TQAQRDFFGAHTYGRIDEPGKFHTLWSSDRTEVPV"
gene complement(2095218..2096168)
/gene="blaR"
/locus_tag="Rv1845c"
CDS complement(2095218..2096168)
/codon_start=1
/transl_table=11
/gene="blaR"
/locus_tag="Rv1845c"
/product="Possible sensor-transducer protein BlaR"
/note="Rv1845c, (MTCY359.28), len: 316 aa. Possible
blaR,sensor-transducer protein. Conserved hypothetical
transmembrane protein. Equivalent to MLCB1788.18|AL008609
Hypothetical protein from Mycobacterium leprae (316
aa),FASTA scores: opt: 1762, E(): 0, (87.6% identity in
314 aa overlap). Similar to proteins in Streptomyces
coelicolor e.g. SC10A7.04|AL078618.1."
/db_xref="EnsemblGenomes-Gn:Rv1845c"
/db_xref="EnsemblGenomes-Tr:CCP44611"
/db_xref="GOA:P95164"
/db_xref="InterPro:IPR001915"
/db_xref="UniProtKB/TrEMBL:P95164"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44611.1"
/translation="MSALAFTILAVLLAGPTPALLARATWPLRAPRAAMVLWQAIALA
AVLSSFSAGIAIASRLLMPGPDGRPTTSFVGAAGRLGWPLWAAYITVFALTVLVGARL
AVAVVRVATATRRRRAHHRMVVDLVGVGHNGALAQPCARARDLRVLDVAQPLAYCLPG
VRSRVVVSEGTLTALADAEVAAILTHERAHLRARHDLVLEAFTAVHAAFPRLVRSANA
LGAVQLLVELLADDAAVRAAGRTPLARALVACASGRAPSGALAVGGPSTVLRVRRLSG
RGNSAVLSAAAYLAAAAVLVVPTVALAVPWLTQLQRLFIA"
gene complement(2096183..2096599)
/gene="blaI"
/locus_tag="Rv1846c"
CDS complement(2096183..2096599)
/codon_start=1
/transl_table=11
/gene="blaI"
/locus_tag="Rv1846c"
/product="Transcriptional repressor BlaI"
/note="Rv1846c, (MTCY359.27), len: 138 aa.
BlaI,transcriptional repressor. Equivalent to
MLCB1788.17|AL008609 hypothetical protein from
Mycobacterium leprae (142 aa), FASTA scores: opt: 736 E():
0, (95.1% identity in 123 aa overlap). Also similar to
BLAI_BACLI|P06555 penicillinase repressor (128 aa), fasta
scores: opt: 114, E(): 0.12, (23.7% identity in 131 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1846c"
/db_xref="EnsemblGenomes-Tr:CCP44612"
/db_xref="GOA:P9WMJ5"
/db_xref="InterPro:IPR005650"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:2G9W"
/db_xref="UniProtKB/Swiss-Prot:P9WMJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44612.1"
/translation="MAKLTRLGDLERAVMDHLWSRTEPQTVRQVHEALSARRDLAYTT
VMTVLQRLAKKNLVLQIRDDRAHRYAPVHGRDELVAGLMVDALAQAEDSGSRQAALVH
FVERVGADEADALRRALAELEAGHGNRPPAGAATET"
gene 2096877..2097299
/locus_tag="Rv1847"
CDS 2096877..2097299
/codon_start=1
/transl_table=11
/locus_tag="Rv1847"
/product="Conserved protein"
/note="Rv1847, (MTCY359.26c), len: 140 aa. Conserved
protein, possible thioesterase, some similarity to YBDB
proteins of Escherichia coli and H. influenzae e.g.
P15050|YBDB_ECOLI hypothetical 15.0 KD protein in
ENTA-CSTA intergenic region (137 aa), FASTA scores: opt:
232, E(): 6.6e-10, (35.8% identity in 106 aa overlap);
C48956|G142208 thioesterase from Arthrobacter sp (151 aa),
FASTA score: opt: 254, E(): 1.7e-11, (33.3% identity in
138 aa overlap). Also similar to AF064959|AF064959_1
hypothetical protein from Coxiella burnetii (148 aa),
FASTA score: opt: 264,E(): 9.3e- 12, (36.8% identity in
117 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1847"
/db_xref="EnsemblGenomes-Tr:CCP44613"
/db_xref="GOA:P9WIM3"
/db_xref="InterPro:IPR003736"
/db_xref="InterPro:IPR006683"
/db_xref="InterPro:IPR029069"
/db_xref="PDB:3S4K"
/db_xref="UniProtKB/Swiss-Prot:P9WIM3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44613.1"
/translation="MQPSPDSPAPLNVTVPFDSELGLQFTELGPDGARAQLDVRPKLL
QLTGVVHGGVYCAMIESIASMAAFAWLNSHGEGGSVVGVNNNTDFVRSISSGMVYGTA
EPLHRGRRQQLWLVTITDDTDRVVARGQVRLQNLEARP"
gene 2097348..2097650
/gene="ureA"
/locus_tag="Rv1848"
CDS 2097348..2097650
/codon_start=1
/transl_table=11
/gene="ureA"
/locus_tag="Rv1848"
/product="Urease gamma subunit UreA (urea amidohydrolase)"
/note="Rv1848, (MTCY359.25c), len: 100 aa. UreA, urease
gamma subunit. Similar to URE3_MYCTU|P50043 from
Mycobacterium tuberculosis (100 aa), FASTA scores: opt:
630, E(): 1.3e-36, (99.0% identity in 100 aa overlap).
Belongs to the urease gamma subunit family."
/db_xref="EnsemblGenomes-Gn:Rv1848"
/db_xref="EnsemblGenomes-Tr:CCP44614"
/db_xref="GOA:P9WFE7"
/db_xref="InterPro:IPR002026"
/db_xref="InterPro:IPR012010"
/db_xref="InterPro:IPR036463"
/db_xref="PDB:2FVH"
/db_xref="UniProtKB/Swiss-Prot:P9WFE7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44614.1"
/translation="MRLTPHEQERLLLSYAAELARRRRARGLRLNHPEAIAVIADHIL
EGARDGRTVAELMASGREVLGRDDVMEGVPEMLAEVQVEATFPDGTKLVTVHQPIA"
gene 2097647..2097961
/gene="ureB"
/locus_tag="Rv1849"
CDS 2097647..2097961
/codon_start=1
/transl_table=11
/gene="ureB"
/locus_tag="Rv1849"
/product="Urease beta subunit UreB (urea amidohydrolase)"
/note="Rv1849, (MTCY359.24c), len: 104 aa. UreB, urease
beta subunit. Identical to URE2_MYCTU|P50048 urease beta
subunit from Mycobacterium tuberculosis (100 aa). Belongs
to the urease gamma subunit family."
/db_xref="EnsemblGenomes-Gn:Rv1849"
/db_xref="EnsemblGenomes-Tr:CCP44615"
/db_xref="GOA:P9WFE9"
/db_xref="InterPro:IPR002019"
/db_xref="InterPro:IPR036461"
/db_xref="UniProtKB/Swiss-Prot:P9WFE9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44615.1"
/translation="MIPGEIFYGSGDIEMNAAALSRLQMRIINAGDRPVQVGSHVHLP
QANRALSFDRATAHGYRLDIPAATAVRFEPGIPQIVGLVPLGGRREVPGLTLNPPGRL
DR"
gene 2097961..2099694
/gene="ureC"
/locus_tag="Rv1850"
CDS 2097961..2099694
/codon_start=1
/transl_table=11
/gene="ureC"
/locus_tag="Rv1850"
/product="Urease alpha subunit UreC (urea amidohydrolase)"
/note="Rv1850, (MTCY359.23c), len: 577 aa. UreC, urease
alpha subunit. Similar to URE1_MYCTU|P50042 from
Mycobacterium tuberculosis (577 aa), FASTA scores: opt:
3794, E(): 0, (98.3% identity in 577 aa overlap). Contains
PS00145 Urease active site motif. Belongs to the urease
family."
/db_xref="EnsemblGenomes-Gn:Rv1850"
/db_xref="EnsemblGenomes-Tr:CCP44616"
/db_xref="GOA:P9WFF1"
/db_xref="InterPro:IPR005848"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR011059"
/db_xref="InterPro:IPR011612"
/db_xref="InterPro:IPR017950"
/db_xref="InterPro:IPR017951"
/db_xref="InterPro:IPR029754"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/Swiss-Prot:P9WFF1"
/inference="protein motif:PROSITE:PS00145"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44616.1"
/translation="MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAG
DEAVFGGGKVLRESMGQGRASRADGAPDTVITGAVIIDYWGIIKADIGIRDGRIVGIG
KAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTT
IIGGGTGPAEGTKATTVTPGEWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRG
GASGFKLHEDWGSTPAAIDTCLAVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIH
AYHTEGAGGGHAPDIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIP
EDLAFAESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMKARR
GALEGDPSGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKLADLVLWEPAFF
GVRPHVVLKGGAIAWAAMGDANASIPTPQPVLPRPMFGAAAATAAATSVHFVAPQSID
ARLADRLAVNRGLAPVADVRAVGKTDLPLNDALPSIEVDPDTFTVRIDGQVWQPQPAA
ELPMTQRYFLF"
gene 2099694..2100329
/gene="ureF"
/locus_tag="Rv1851"
CDS 2099694..2100329
/codon_start=1
/transl_table=11
/gene="ureF"
/locus_tag="Rv1851"
/product="Urease accessory protein UreF"
/note="Rv1851, (MTCY359.22c), len: 211 aa. UreF, urease
accessory protein. Identical to UREF_MYCTU|P50050 from M.
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv1851"
/db_xref="EnsemblGenomes-Tr:CCP44617"
/db_xref="GOA:P9WFE5"
/db_xref="InterPro:IPR002639"
/db_xref="InterPro:IPR038277"
/db_xref="UniProtKB/Swiss-Prot:P9WFE5"
/protein_id="CCP44617.1"
/translation="MTSLAVLLTLADSRLPTGAHVHSGGIEEAIAAGMVTGLATLEAF
LKRRVRTHGLLTASIAAAVHRGELAVDDADRETDARTPAPAARHASRSQGRGLIRLAR
RVWPDSGWEELGPRPHLAVVAGRVGALSGLAPEHNALHLVYITMTGSAIAAQRLLALD
PAEVTVVTFQLSELCEQIAQEATAGLADLSDPLLDTLAQRHDERVRPLFVS"
gene 2100340..2101014
/gene="ureG"
/locus_tag="Rv1852"
CDS 2100340..2101014
/codon_start=1
/transl_table=11
/gene="ureG"
/locus_tag="Rv1852"
/product="Urease accessory protein UreG"
/note="Rv1852, (MTCY359.21c), len: 224 aa. UreG, urease
accessory protein. Identical to UREG_MYCTU|P50051 from M.
tuberculosis. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Belongs to the UreG family."
/db_xref="EnsemblGenomes-Gn:Rv1852"
/db_xref="EnsemblGenomes-Tr:CCP44618"
/db_xref="GOA:P9WFE3"
/db_xref="InterPro:IPR003495"
/db_xref="InterPro:IPR004400"
/db_xref="InterPro:IPR012202"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WFE3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44618.1"
/translation="MATHSHPHSHTVPARPRRVRKPGEPLRIGVGGPVGSGKTALVAA
LCRQLRGELSLAVLTNDIYTTEDADFLRTHAVLPDDRIAAVQTGGCPHTAIRDDITAN
LDAIDELMAAHDALDLILVESGGDNLTATFSSGLVDAQIFVIDVAGGDKVPRKGGPGV
TYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSLTEDPAASDVVAWVRSQ
LAADGV"
gene 2101022..2101648
/gene="ureD"
/locus_tag="Rv1853"
CDS 2101022..2101648
/codon_start=1
/transl_table=11
/gene="ureD"
/locus_tag="Rv1853"
/product="Probable urease accessory protein UreD"
/note="Rv1853, (MTCY359.20c), len: 208 aa. UreD, probable
urease accessory protein. Similar to URED_YEREN|P42868
Urease operon ureD protein from Yersinia enterocolitica
(325 aa), Fasta scores: opt: 114, E(): 0.37, (25.2%
identity in 119 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1853"
/db_xref="EnsemblGenomes-Tr:CCP44619"
/db_xref="GOA:P95161"
/db_xref="InterPro:IPR002669"
/db_xref="UniProtKB/TrEMBL:P95161"
/protein_id="CCP44619.1"
/translation="MVASPNRLPRIDCRGGVQARRTAPDTVHLVSAAATPLGGDTMRI
RVIVERGAQLRLRSAAATVALPGVDTLTSHAHWEIDVTGTLDVDLEPTVVAASARHLS
HATLRLHDDGRVRLRERVQIGRCNEREGFWSSSLQADRHGRPLLRHRVELGAGSLADD
VIAAPRATISELRYPATAFTDAIDARSTVLALAGGGTLSTWQADRLPG"
gene complement(2101651..2103042)
/gene="ndh"
/locus_tag="Rv1854c"
CDS complement(2101651..2103042)
/codon_start=1
/transl_table=11
/gene="ndh"
/locus_tag="Rv1854c"
/product="Probable NADH dehydrogenase Ndh"
/note="Rv1854c, (MTCY359.19), len: 463 aa. Probable
ndh,NADH dehydrogenase (see citations below), similar to
several e.g. S74826 NADH dehydrogenase from Synechocystis
sp. (445 aa), FASTA score: opt: 1228, E(): 0, (46.3%
identity in 432 aa overlap). Highly similar to
Rv0392c|Z84725|g1817703 from Mycobacterium tuberculosis
(470 aa), FASTA scores: opt: 1911, E(): 0, (64.7% identity
in 459 aa overlap); and Rv1812c."
/db_xref="EnsemblGenomes-Gn:Rv1854c"
/db_xref="EnsemblGenomes-Tr:CCP44620"
/db_xref="GOA:P95160"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:P95160"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44620.1"
/translation="MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIA
RTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSE
LLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAER
SSDPERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAP
AVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVW
SAGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQ
GAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIA
WLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAA
EAQGSAASAKVAS"
gene complement(2103184..2104107)
/locus_tag="Rv1855c"
CDS complement(2103184..2104107)
/codon_start=1
/transl_table=11
/locus_tag="Rv1855c"
/product="Possible oxidoreductase"
/note="Rv1855c, (MTCY359.18), len: 307 aa. Possible
oxidoreductase, possibly a monooxygenase. Contains PS00217
Sugar transport proteins signature 2, probably
fortuitously. Similar to G487716 (78-11) lincomycin
production genes (29.2% identity in 154 aa overlap). Also
similar to other Mycobacterium tuberculosis proteins e.g.
Rv0953c, Rv0791c, Rv0132c, Rv2951c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1855c"
/db_xref="EnsemblGenomes-Tr:CCP44621"
/db_xref="GOA:P95159"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019952"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:P95159"
/inference="protein motif:PROSITE:PS00217"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44621.1"
/translation="MTIRLGLQIPNFSYGTGVEKLFPSVIAQAREAEAAGYDSLFVMD
HFYQLPMLGTPDQPMLEAYTALGALATATERLQLGALVTGNTYRSPTLLAKIITTLDV
VSAGRAILGIGAGWFELEHRQLGFEFGTFSDRFNRLEEALQILEPMVKGERPTFFGDW
YTTESAMAEPRYRDRIPILIGGGGEKKTFAIAARFADHLNIVAAVDELPRKMRALAAR
CDEAGRDRSTLQTSLLLTVMIDETLSPDAIPAEMSGRVVVGSPAQIADQIQAKVLDAG
VDGLIINLAPHGYLPGVITTAAEALRPLLGV"
gene complement(2104146..2104823)
/locus_tag="Rv1856c"
CDS complement(2104146..2104823)
/codon_start=1
/transl_table=11
/locus_tag="Rv1856c"
/product="Possible oxidoreductase"
/note="Rv1856c, (MTCY359.17), len: 225 aa. Possible
oxidoreductase. Equivalent to MLCB1788.11c|AL008609
oxidoreductase from Mycobacterium leprae (224 aa), FASTA
scores: opt: 1211, E(): 0; (80.4% identity in 224 aa
overlap). Some similarity to dehydrogenases of short-chain
dehydrogenase/reductase family and fatty-acyl CoA
reductases e.g. P16543|DHK2_STRVN granaticin polyketide
synthase P (249 aa), FASTA score: opt: 194, E():
1.1e-05,(32.5% identity in 237 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1856c"
/db_xref="EnsemblGenomes-Tr:CCP44622"
/db_xref="GOA:P9WGQ1"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGQ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44622.1"
/translation="MAVEVLVTGGDTDLGRTMAEGFRNDGHKVTLVGARRGDLEVAAK
ELDVDAVVCDTTDPTSLTEARGLFPRHLDTIVNVPAPSWDAGDPRAYSVSDTANAWRN
ALDATVLSVVLTVQSVGDHLRSGGSIVSVVAENPPAGGAESAIKAALSNWIAGQAAVF
GTRGITINTVACGRSVQTGYEGLSRTPAPVAAEIARLALFLTTPAARHITGQTLHVSH
GALAHFG"
gene 2104985..2105770
/gene="modA"
/locus_tag="Rv1857"
CDS 2104985..2105770
/codon_start=1
/transl_table=11
/gene="modA"
/locus_tag="Rv1857"
/product="Probable molybdate-binding lipoprotein ModA"
/note="Rv1857, (MTCY359.16c), len: 261 aa. Probable
modA,molybdate-binding protein attached to membrane by
lipid-modified N-terminal cysteine (contains PS00013
Prokaryotic membrane lipoprotein lipid attachment
site),component of molybdate transport system (see
citations below). Shows strong similarity to precursors of
periplasmic molybdate/sulphate binding proteins e.g.
O31229|Y10817|ANY108174 ModA from Arthrobacter
nicotinovorans (260 aa), FASTA score: opt: 725, E():
0,(47.8% identity in 249 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1857"
/db_xref="EnsemblGenomes-Tr:CCP44623"
/db_xref="GOA:P9WGU3"
/db_xref="InterPro:IPR005950"
/db_xref="UniProtKB/Swiss-Prot:P9WGU3"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44623.1"
/translation="MRWIGLSTGLVSAMLVAGLVACGSNSPASSPAGPTQGARSIVVF
AAASLQSAFTQIGEQFKAGNPGVNVNFAFAGSSELATQLTQGATADVFASADTAQMDS
VAKAGLLAGHPTNFATNTMVIVAAAGNPKKIRSFADLTRPGLNVVVCQPSVPCGSATR
RIEDATGIHLNPVSEELSVTDVLNKVITGQADAGLVYVSDALSVATKVTCVRFPEAAG
VVNVYAIAVLKRTSQPALARQFVAMVTAAAGRRILDQSGFAKP"
gene 2105773..2106567
/gene="modB"
/locus_tag="Rv1858"
CDS 2105773..2106567
/codon_start=1
/transl_table=11
/gene="modB"
/locus_tag="Rv1858"
/product="Probable molybdenum-transport integral membrane
protein ABC transporter ModB"
/note="Rv1858, (MTCY359.15c), len: 264 aa. Probable
modB,molybdenum-transport integral membrane protein ABC
transporter (see citation below), similar to others e.g.
Y10817|ANY108175 ModB from Arthrobacter (239 aa), FASTA
scores: opt: 937, E(): 0, (67.8% identity in 230 aa
overlap); etc. Similar to other Mycobacterium tuberculosis
transport proteins e.g. Rv2039c, Rv2316, etc."
/db_xref="EnsemblGenomes-Gn:Rv1858"
/db_xref="EnsemblGenomes-Tr:CCP44624"
/db_xref="GOA:P9WG13"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR006469"
/db_xref="InterPro:IPR011867"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/Swiss-Prot:P9WG13"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44624.1"
/translation="MHPPTDLPRWVYLPAIAGIVFVAMPLVAIAIRVDWPRFWALITT
PSSQTALLLSVKTAAASTVLCVLLGVPMALVLARSRGRLVRSLRPLILLPLVLPPVVG
GIALLYAFGRLGLIGRYLEAAGISIAFSTAAVVLAQTFVSLPYLVISLEGAARTAGAD
YEVVAATLGARPGTVWWRVTLPLLLPGVVSGSVLAFARSLGEFGATLTFAGSRQGVTR
TLPLEIYLQRVTDPDAAVALSLLLVVVAALVVLGVGARTPIGTDTR"
gene 2106574..2107683
/gene="modC"
/locus_tag="Rv1859"
CDS 2106574..2107683
/codon_start=1
/transl_table=11
/gene="modC"
/locus_tag="Rv1859"
/product="Probable molybdenum-transport ATP-binding
protein ABC transporter ModC"
/note="Rv1859, (MTCY359.14c), len: 369 aa. Probable
modC,molybdenum-transport ATP-binding protein ABC
transporter (see citation below), similar to others e.g.
Y10817|ANY108176 ModC from Arthrobacter (349 aa), FASTA
scores: opt: 895, E(): 0, (46.0% identity in 361 aa
overlap); etc. Shows similarity to other Mycobacterium
tuberculosis ABC-transporter proteins e.g. Rv0073,
Rv1238,Rv2564, etc. Contains both PS00017 ATP/GTP-binding
site motif A (P-loop) and PS00211 ABC transporters family
signatures involved in molybdate uptake. Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv1859"
/db_xref="EnsemblGenomes-Tr:CCP44625"
/db_xref="GOA:P9WQL3"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005116"
/db_xref="InterPro:IPR008995"
/db_xref="InterPro:IPR015852"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQL3"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/protein_id="CCP44625.1"
/translation="MSKLQLRAVVADRRLDVEFSVSAGEVLAVLGPNGAGKSTALHVI
AGLLRPDAGLVRLGDRVLTDTEAGVNVATHDRRVGLLLQDPLLFPHLSVAKNVAFGPQ
CRRGMFGSGRARTRASALRWLREVNAEQFADRKPRQLSGGQAQRVAIARALAAEPDVL
LLDEPLTGLDVAAAAGIRSVLRSVVARSGCAVVLTTHDLLDVFTLADRVLVLESGTIA
EIGPVADVLTAPRSRFGARIAGVNLVNGTIGPDGSLRTQSGAHWYGTPVQDLPTGHEA
IAVFPPTAVAVYPEPPHGSPRNIVGLTVAEVDTRGPTVLVRGHDQPGGAPGLAACITV
DAATELRVAPGSRVWFSVKAQEVALHPAPHQHASS"
gene 2107736..2108713
/gene="apa"
/gene_synonym="modD"
/gene_synonym="mpt32"
/locus_tag="Rv1860"
CDS 2107736..2108713
/codon_start=1
/transl_table=11
/gene="apa"
/gene_synonym="modD"
/gene_synonym="mpt32"
/locus_tag="Rv1860"
/product="Alanine and proline rich secreted protein Apa
(fibronectin attachment protein) (immunogenic protein
MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa
antigen)"
/note="Rv1860, (MT1908, MTCY359.0013), len: 325 aa. Apa
(alternate gene names: mpt32, modD), Ala-, Pro-rich 45/47
kDa secreted protein, very similar to P46842|N43L_MYCLE
from Mycobacterium leprae (287 aa), FASTA scores: opt:
1166, E(): 0, (66.4% identity in 298 aa overlap). Known to
be glycosylated fibronectin-binding protein (see some
citations). Changes in the mannosylation pattern of this
protein affect its ability to stimulate T-lymphocyte
response. Major immunodominant antigen that has potential
as a vaccine against tuberculosis. APA-ELISA could be used
in diagnosis."
/db_xref="EnsemblGenomes-Gn:Rv1860"
/db_xref="EnsemblGenomes-Tr:CCP44626"
/db_xref="GOA:P9WIR7"
/db_xref="InterPro:IPR010801"
/db_xref="PDB:5ZX9"
/db_xref="PDB:5ZXA"
/db_xref="UniProtKB/Swiss-Prot:P9WIR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44626.1"
/translation="MHQVDPNLTRRKGRLAALAIAAMASASLVTVAVPATANADPEPA
PPVPTTAASPPSTAAAPPAPATPVAPPPPAAANTPNAQPGDPNAAPPPADPNAPPPPV
IAPNAPQPVRIDNPVGGFSFALPAGWVESDAAHFDYGSALLSKTTGDPPFPGQPPPVA
NDTRIVLGRLDQKLYASAEATDSKAAARLGSDMGEFYMPYPGTRINQETVSLDANGVS
GSASYYEVKFSDPSKPNGQIWTGVIGSPAANAPDAGPPQRWFVVWLGTANNPVDKGAA
KALAESIRPLVAPPPAPAPAPAEPAPAPAPAGEVAPTPTTPTPQRTLPA"
gene 2109165..2109470
/locus_tag="Rv1861"
CDS 2109165..2109470
/codon_start=1
/transl_table=11
/locus_tag="Rv1861"
/product="Probable conserved transmembrane protein"
/note="Rv1861, (MTCY359.12c), len: 101 aa. Probable
conserved transmembrane protein, showing weak similarity
to AE002069|AE002069_10 hypothetical protein from
Deinococcus radiodurans (146 aa), FASTA scores: opt: 154,
E(): 0.0027,(30.8% identity in 104 aa overlap). Contains
PS00017 ATP/GTP-binding site motif A (P-loop). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1861"
/db_xref="EnsemblGenomes-Tr:CCP44627"
/db_xref="GOA:P95154"
/db_xref="InterPro:IPR007341"
/db_xref="UniProtKB/TrEMBL:P95154"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP44627.1"
/translation="MDITATTEFSAMNLDGKTGIGWLGYIVIGGIAGWLASKIVKGGG
SGILMNVVIGVVGAFGAGLVLNALGVDVNHGGYWFTFFVALGGAVVLLWIVGMVRKT"
gene 2109544..2110584
/gene="adhA"
/locus_tag="Rv1862"
CDS 2109544..2110584
/codon_start=1
/transl_table=11
/gene="adhA"
/locus_tag="Rv1862"
/product="Probable alcohol dehydrogenase AdhA"
/note="Rv1862, (MTCY359.11), len: 346 aa. Probable
adhA,alcohol dehydrogenase, similar to ADH2_BACST|P42327
alcohol dehydrogenase (339 aa), FASTA scores: opt: 630,
E(): 2.4e-32 (34.4% identity in 320 aa overlap). Contains
PS00059 Zinc-containing alcohol dehydrogenases signature."
/db_xref="EnsemblGenomes-Gn:Rv1862"
/db_xref="EnsemblGenomes-Tr:CCP44628"
/db_xref="GOA:P9WQC1"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR014187"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WQC1"
/inference="protein motif:PROSITE:PS00059"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44628.1"
/translation="MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVA
VHACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGI
AWLRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEFTTVPAAFAHHLPSGYSDSEL
APLLCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHVMTRGARAR
KLALQLGAASAQDAADRPPVPLDAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDI
PDLNYQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPEYPLGQADRALGDLS
AGRIAGAAVLLI"
gene complement(2110591..2111361)
/locus_tag="Rv1863c"
CDS complement(2110591..2111361)
/codon_start=1
/transl_table=11
/locus_tag="Rv1863c"
/product="Probable conserved integral membrane protein"
/note="Rv1863c, (MTCY359.10), len: 256 aa. Probable
conserved integral membrane protein, similar to
Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from
Mycobacterium tuberculosis (209 aa), FASTA scores: opt:
199, E(): 1e-06, (33.2% identity in 220 aa overlap); and
Rv0658c."
/db_xref="EnsemblGenomes-Gn:Rv1863c"
/db_xref="EnsemblGenomes-Tr:CCP44629"
/db_xref="GOA:P95152"
/db_xref="InterPro:IPR003675"
/db_xref="InterPro:IPR015837"
/db_xref="UniProtKB/TrEMBL:P95152"
/protein_id="CCP44629.1"
/translation="MSDHLTACAAVHPGPLVSHLSVMHRFRIYVDIAVVVLVLVLTNL
IAHFTTPWASIATVPAAAVGLVILVRSRGLGWAELGLSRQHWKSGLVYALAAVALVVA
VISVGVLLPITRPMFMNHHYATISGAVIASMVMIPLQTVIPEELAFRGVLHGALNRAW
GFRGVAVAGSVLFGLWHIATSLGLTSSNVGFTRLFGGGIIGLVAGVMLAVLATGVAGF
VFSWLRRRSGSLIAPIALHWSLNGMGALAAALVWHLST"
gene complement(2111354..2112109)
/locus_tag="Rv1864c"
CDS complement(2111354..2112109)
/codon_start=1
/transl_table=11
/locus_tag="Rv1864c"
/product="Conserved protein"
/note="Rv1864c, (MTCY359.09), len: 251 aa. Conserved
protein. Similar to other hypothetical proteins e.g.
AL031317|SC6G4.43 from Streptomyces coelicolor cosmid 6G
(233 aa), FASTA scores: opt: 716, E(): 0, (54.4% identity
in 215 aa overlap); also P43976|YIIM_HAEIN hypothetical
protein hi0278 (221 aa), FASTA scores: opt: 223, E():
3.8e-08, (29.5% identity in 173 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1864c"
/db_xref="EnsemblGenomes-Tr:CCP44630"
/db_xref="GOA:P95151"
/db_xref="InterPro:IPR005302"
/db_xref="InterPro:IPR011037"
/db_xref="UniProtKB/TrEMBL:P95151"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44630.1"
/translation="MTVAPRRLAWTNARQSYPVRVAHVLSVNLARVRANPDPRAQSKL
TGIDKVAASEAVMVRAPGSMHAGVGSGLVGDTVGNPKLHGGDDQAVYAYAREDLDAWE
TQLHRTLHNGMFGENLTTSGVDVTYARIGERWRIGSDGLVLEVSAPRIPCRTFAAFLD
LRYWIKTFTRAAKPGAYLRVIAPGTVRAGDTITVDYRPEHNVTVGLVFRARTSESELL
PQLLAADALAAELKAYARERTPSPPPVDSADDV"
gene complement(2112106..2112966)
/locus_tag="Rv1865c"
CDS complement(2112106..2112966)
/codon_start=1
/transl_table=11
/locus_tag="Rv1865c"
/product="Probable short-chain type dehydrogenase"
/note="Rv1865c, (MTCY359.08), len: 286 aa. Probable
short-chain dehydrogenase, highly similar to C-terminus of
NP_301650.1|NC_00267 putative oxidoreductase from
Mycobacterium leprae (596 aa). Also similar to various
dehydrogenases, generally belonging to short-chain
family,e.g. AAG02168.1|AF212041_24|AF212041
3-oxoacyl-(acylcarrier protein) reductase from Zymomonas
mobilis (251 aa); P50198|LINX_PSEPA
2,5-dichloro-2,5-cyclohexadiene-1,4-DIOL dehydrogenase
from Sphingomonas paucimobilis (250 aa);
NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar
to acetoin reductase) from Mesorhizobium loti (256 aa);
etc. And highly similar to C-terminus of
ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis
(592 aa); and many other oxidoreductases from
Mycobacterium tuberculosis e.g. Y00P_MYCTU|Q10402 putative
oxidoreductase (650 aa), FASTA scores: opt: 439, E():
8.9e-20, (32.5% identity in 280 aa overlap). Contains
PS00061 Short-chain alcohol dehydrogenase family
signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1865c"
/db_xref="EnsemblGenomes-Tr:CCP44631"
/db_xref="GOA:P95150"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P95150"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44631.1"
/translation="MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKV
AIGDIDEAMAKESGADLDLDMYGKLDVTDPDSFSGFLDAVERQLGPIDVLVNNAGIMP
VGRIVDEPDPVTRRILDINVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVA
TYCASKHAVVAFTDSARLEYRSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIA
DAIVGLIVHPKPRVRVTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRR
TYEARARGEE"
gene 2113140..2115476
/locus_tag="Rv1866"
CDS 2113140..2115476
/codon_start=1
/transl_table=11
/locus_tag="Rv1866"
/product="Conserved protein"
/note="Rv1866, (MTCY359.07c), len: 778 aa. Conserved
protein, N-terminal region similar to fatty acyl-CoA
racemases e.g. Rv0855, Rv1143, and C-terminal region (from
aa 370) similar to L-carnitine dehydratases, racemases,
and Rv3272|MTCY71.12 Mycobacterium tuberculosis (394 aa),
FASTA score: opt: 472, E(): 2.1e-21, (29.9% identity in
388 aa overlap). Also similar to P31572|CAIB_ECOLI
L-carnitine dehydratase (405 aa), FASTA score: opt: 306,
E(): 2.1e-11,(23.3% identity in 424 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1866"
/db_xref="EnsemblGenomes-Tr:CCP44632"
/db_xref="GOA:P95149"
/db_xref="InterPro:IPR003673"
/db_xref="InterPro:IPR023606"
/db_xref="UniProtKB/Swiss-Prot:P95149"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44632.1"
/translation="MVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNAN
KRSAVLNPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVALSI
TDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATAAVQAAWAVLV
AYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGIRSTGRWRGRPKNQDAYPI
YPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQDPKYDVIGARLAAWPQISVLVAKLCA
EKTMKELVAAGQALGVPITAVLTPSRILASEHFQAVGAITDAELVPGVRTGVPTGYFV
VDGKRAGFRTPAPAAGQDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGEL
SRLFGDLGAEVIKVESADHPDGLRQTRVGDAMSESFAWTHRNHLALGLDLRNSEGKAI
FGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGNRGPWSTRMGYG
PLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVVGRVGALLALAALIHRDRTG
GGAHVHISQAEVVVNQLDTMFVAEAARATDVAEIHPDTSVHAVYPCAGDDEWCVISIR
SDDEWRRATSVFGQPELANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQA
AGVAAGPMNRPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQAPQRPA
PLPGQDSVQICRKLLGMTADETERLINERVMFGPAVTA"
gene 2115764..2117248
/locus_tag="Rv1867"
CDS 2115764..2117248
/codon_start=1
/transl_table=11
/locus_tag="Rv1867"
/product="Conserved protein"
/note="Rv1867, (MTCY359.06c), len: 494 aa. Conserved
protein, some similarity to acetyl CoA synthase and to
lipid carriers. FASTA best: E155295 acetyl CoA synthase
(388 aa), opt: 213, E(): 4.5e-07, (23.2% identity in 423
aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv1867"
/db_xref="EnsemblGenomes-Tr:CCP44633"
/db_xref="GOA:P95148"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR040771"
/db_xref="UniProtKB/TrEMBL:P95148"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44633.1"
/translation="MPVDPRTPVLIGYGQVNHRGDIDAEKQSIEPVDLMAAAARKAAD
STVLEAVDSIRVVHMLSAHYRNPGQLLGERIKARTFTTGYSGVGGNMPQSLVNRACLD
IQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWTVQDESVPLPDMAGDDVPMAGAAELR
INLDRPAYVYPIFEQALRIAYGESIENHRKRIGELWARFSAVAADNPHAWIRNPVTAD
EIWQPGPQNRMVSWPYTKLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTD
AHDTPAVADRHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELG
LDTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITANGGYLTKH
SFGVYGTEPPSEFRWEDMQPAVDREPTGDGLVEWEGIGTVEAWTTPVNRDGQPEKAFL
AVRTPDGSRSLAVITDPASVQATVREDIAGVKVAVAPDGTATLR"
gene 2117347..2119446
/locus_tag="Rv1868"
CDS 2117347..2119446
/codon_start=1
/transl_table=11
/locus_tag="Rv1868"
/product="Conserved hypothetical protein"
/note="Rv1868, (MTCY359.05c), len: 699 aa. Conserved
hypothetical protein, similar to products of three
consecutive ORFS in Mycobacterium leprae
MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt:
314,E(): 9.9e-12, (35.2% identity in 213 aa overlap);
MLCB2052.17, and MLCB2052.16. Also similar to M.
tuberculosis hypothetical protein Rv2047c."
/db_xref="EnsemblGenomes-Gn:Rv1868"
/db_xref="EnsemblGenomes-Tr:CCP44634"
/db_xref="GOA:P95147"
/db_xref="InterPro:IPR016040"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P95147"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44634.1"
/translation="MQILVTDATGAVGRSVTRQLIAAGHTVSGIAQHPHDALDPRVDY
VCASLRNPVLQELAGEADAVIHLAPVDTSAPGGVGITGLAHVANAAARAGARLLFVSQ
AAGRPELYRQAETLVSTGWAPSLVIRIAPPVGRQLDWMVCRTVATLLRSKVSARPIRV
LHLDDLVRFLVLALNTDRNGVVDLATPDTTNVVTAWRLLRSVDPHLRTRRVRSWEQLI
PEVDIAAVQEDWNFEFGWQATEAIVDTGRGLVGRRLHPAGATNGSGQLALPVEAPPRS
VPSHGEPLGSAAPEGLEGEFDDRIDERFPVFSSASLAEALPGPLTPMTLDVQLSGLRA
AGRAMGRVLALGGVVADEWERRAIAVFGHRPYIGVSANIVAAAQLPGWDAQAVARRAL
GEQPQVTELLPFGRPQLAGGPLGSVAKVVVTARSLALLRHLRSDTHHYVAAADAEHLA
AGQLASLPDAGLEVRIRLLRDRIHQGWILTVLWVIDTGVTAATLEHTRAGSAVSGGGM
IMESGRIGAEIAPLAAVLRADPPLCALANDGNLASIRALSAPAAAAVDAVIARIGHRG
LGEAELANLTFADDPALLLKTAAEIAARPAGPAHPATLIQRLAAGTRSARELAHDTTI
RFTHELRMTLRELGSRRVAADVIDVVDDVFYLTCDELITTPADARLRIKRRRAERERL
QAQRPPDVIDHAWVPVE"
gene complement(2119460..2120695)
/locus_tag="Rv1869c"
CDS complement(2119460..2120695)
/codon_start=1
/transl_table=11
/locus_tag="Rv1869c"
/product="Probable reductase"
/note="Rv1869c, (MTCY359.04), len: 411 aa. Probable
reductase (1.-.-.-). Similar to several reductases e.g.
CAC04223.1|AL391515 putative ferredoxin reductase from
Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494
rhodocoxin reductase (426 aa), FASTA scores: opt: 904,
E(): 0, (40.8% identity in 370 aa overlap). Also similar
to Mycobacterium tuberculosis proteins Rv0688 (406 aa)
(39.9% identity in 391 aa overlap); and Rv0253 (nitrite
reductase subunit)."
/db_xref="EnsemblGenomes-Gn:Rv1869c"
/db_xref="EnsemblGenomes-Tr:CCP44635"
/db_xref="GOA:P95146"
/db_xref="InterPro:IPR016156"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR028202"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:P95146"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44635.1"
/translation="MASSTTFVIVGGGLAGAKAVEALRRSDFGGRIILFGDEEHLPYD
RPPLSKEFLAGKKSLSDFTIQTSDWYRDHDVDVRLGVRVSSLDRSAHTVELPDGAAVR
YDKLLLATGSAPRRPPIPGSDAAGVHYLRSYNDAVALNSVLVQGSSLAVVGAGWIGLE
VAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVDLRLQTQLEEITAAD
GKATGLKMRDGSTVAADAVLVAVGAKPNVELAQQAGLAMGEGGVLVDASLRTSDPDIY
AVGDIAAAEHPLLGTRVRTEHWANALKQPAVAAAGMLGRPGEYAELPYLFTDQYDLGM
EYVGHAPSCDRVVFRGNVAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSGNP
VDVDRLVDPQWPLADLTTN"
gene complement(2120795..2121430)
/locus_tag="Rv1870c"
CDS complement(2120795..2121430)
/codon_start=1
/transl_table=11
/locus_tag="Rv1870c"
/product="Conserved hypothetical protein"
/note="Rv1870c, (MTCY359.03), len: 211 aa. Conserved
hypothetical protein. Some similarity to SC6F7.17c
hypothetical protein from Streptomyces coelicolor (216
aa)."
/db_xref="EnsemblGenomes-Gn:Rv1870c"
/db_xref="EnsemblGenomes-Tr:CCP44636"
/db_xref="GOA:P95145"
/db_xref="InterPro:IPR011257"
/db_xref="UniProtKB/TrEMBL:P95145"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44636.1"
/translation="MPPRIAGMRLLVIKPEPLARRLLKLAGTTYAAEAGIRIRDKPMP
LFQLLVLCMLASKPIGAATAARAARELFCSGLRTPKAVLSAERQTMISAFGRAHYVRY
DESSATRLTAIAHRVRDEYSGDLRELAQRTRPDVSAAKRMLKTFNGIGDTGADIFLRE
VQDVWIWVRPYFDDRATAAAKQLGLPTDPKKLASVAPSSNALLAAALVRVA"
gene complement(2121495..2121884)
/locus_tag="Rv1871c"
CDS complement(2121495..2121884)
/codon_start=1
/transl_table=11
/locus_tag="Rv1871c"
/product="Conserved protein"
/note="Rv1871c, (MTCY359.02), len: 129 aa. Conserved
protein, similar to Mycobacterium tuberculosis
hypothetical proteins Q11057|Rv1261|MTCY50.21 (149 aa),
FASTA score: opt: 125, E(): 0.019, (32.6% identity in 89
aa overlap); Rv0523c, and Rv1598c."
/db_xref="EnsemblGenomes-Gn:Rv1871c"
/db_xref="EnsemblGenomes-Tr:CCP44637"
/db_xref="GOA:P95144"
/db_xref="InterPro:IPR004378"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/TrEMBL:P95144"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44637.1"
/translation="MNAAMNLKREFVHRVQRFVVNPIGRQLPMTMLETIGRKTGQPRR
TAVGGRVVDNQFWMVSEHGEHSDYVYNIKANPAVRVRIGGRWRSGTAYLLPDDDPRQR
LRGLPRLNSAGVRAMGTDLLTIRVDLD"
gene complement(2121907..2123151)
/gene="lldD2"
/locus_tag="Rv1872c"
CDS complement(2121907..2123151)
/codon_start=1
/transl_table=11
/gene="lldD2"
/locus_tag="Rv1872c"
/product="Possible L-lactate dehydrogenase (cytochrome)
LldD2"
/note="Rv1872c, (MTCY180.46, MTCY359.01), len: 414 aa
(start uncertain). Possible lldD2, L-lactate dehydrogenase
(cytochrome), similar to other lactate dehydrogenases and
other oxidases e.g. LLDD_ECOLI|P33232 l-lactate
dehydrogenase (cytochrome) from Escherichia coli strain
K12 (396 aa), FASTA results: opt: 674, E(): 1.1e-37,
(40.5% identity in 279 aa overlap); Q51135 lactate
dehydrogenase from Neisseria meningitidis (390 aa), FASTA
results: opt: 309, E(): 4.1e-15, (42.5% identity in 113 aa
overlap); etc. Also shows similarity with
Rv0694|lldD1|MTCY210.11 possible L-lactate dehydrogenase
(cytochrome) from Mycobacterium tuberculosis (396 aa).
Contains PS00557 FMN-dependent alpha-hydroxy acid
dehydrogenases active site. Belongs to the FMN-dependent
alpha-hydroxy acid dehydrogenases family. Phosphorylated
in vitro by PknJ|Rv2088 (See Arora et al.,2010)."
/db_xref="EnsemblGenomes-Gn:Rv1872c"
/db_xref="EnsemblGenomes-Tr:CCP44638"
/db_xref="GOA:P9WND5"
/db_xref="InterPro:IPR000262"
/db_xref="InterPro:IPR008259"
/db_xref="InterPro:IPR012133"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR037396"
/db_xref="UniProtKB/Swiss-Prot:P9WND5"
/inference="protein motif:PROSITE:PS00557"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44638.1"
/translation="MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIA
KRRTPRAAFDYADGGAEDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPTVL
PFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQL
YMWRDRDRSMALVRRVAAAGFDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDA
MGHPRWWFDLLTTEPLAFASLDRWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVV
KGIQTLDDARAVVDRGVDGIVLSNHGGRQLDRAPVPFHLLPHVARELGKHTEILVDTG
IMSGADIVAAIALGARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTC
LEELSPRHVTQLRRLGPIGAPT"
gene 2123174..2123611
/locus_tag="Rv1873"
CDS 2123174..2123611
/codon_start=1
/transl_table=11
/locus_tag="Rv1873"
/product="Conserved hypothetical protein"
/note="Rv1873, (MTCY180.45c), len: 145 aa. Conserved
hypothetical protein. Some similarity to AL591783
hypothetical protein from Sinorhizobium meliloti."
/db_xref="EnsemblGenomes-Gn:Rv1873"
/db_xref="EnsemblGenomes-Tr:CCP44639"
/db_xref="InterPro:IPR014937"
/db_xref="InterPro:IPR036287"
/db_xref="PDB:2JEK"
/db_xref="UniProtKB/TrEMBL:O07756"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44639.1"
/translation="MKSASDPFDLKRFVYAQAPVYRSVVEELRAGRKRGHWMWFVFPQ
LRGLGSSPLAVRYGISSLEEAQAYLQHDLLGPRLHECTGLVNQVQGRSIEEIFGPPDD
LKLCSSMTLFARATDANQDFVALLAKYYGGGEDRRTVALLAVT"
gene 2123684..2124370
/locus_tag="Rv1874"
CDS 2123684..2124370
/codon_start=1
/transl_table=11
/locus_tag="Rv1874"
/product="Unknown protein"
/note="Rv1874, (MTCY180.44c), len: 228 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1874"
/db_xref="EnsemblGenomes-Tr:CCP44640"
/db_xref="GOA:O07755"
/db_xref="InterPro:IPR009799"
/db_xref="InterPro:IPR011008"
/db_xref="UniProtKB/TrEMBL:O07755"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44640.1"
/translation="MLMRPEPDDDWCARQRAQVADALLGLGVAGLSINVRDSTVRDSL
MTLTTLYPPVAAVVSLWTQQCYGEQVAAALRLLAQECDELGAYLVTESVPLTFPSLVE
SGSRTPGLANIALLRRPDGLDQATWLTRWQRDHTQVAIEAQATFGYTQNWVVRALTPE
APGIAGIVEELFPVAATTDLKAFFGAADDNDLRNRISRMVASTSAFGANQNIDTVPTS
RYVFRTPFKD"
gene 2124381..2124824
/locus_tag="Rv1875"
CDS 2124381..2124824
/codon_start=1
/transl_table=11
/locus_tag="Rv1875"
/product="Conserved protein"
/note="Rv1875, (MTCY180.43c), len: 147 aa. Conserved
protein. Some similarity to Mycobacterium tuberculosis
hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147
aa), FASTA scores: opt: 178, E(): 7.4e-06, (26.9% identity
in 130 aa overlap); Rv0121c and Rv2074. Also similar to
AL079356|SC6G9.21 hypothetical protein from Streptomyces
coelicolor (144 aa), FASTA scores: opt: 239, E(): 3.1
e-09,(38.7% identity in 137 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1875"
/db_xref="EnsemblGenomes-Tr:CCP44641"
/db_xref="GOA:O07754"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR019920"
/db_xref="UniProtKB/TrEMBL:O07754"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44641.1"
/translation="MTTLNEAAALAAAERGLAVVSTVRADGTVQASLVNVGLLPHPVS
GEPSLGFTTYGKVKLGNLRARPQLAVTFRNGWQWATVEGRAQLVGPDDPRPWLVDGER
LRLLLREVFTAAGGTHDDWDEYDRVMAQEQRAVVLITPTRIYSNG"
gene 2125340..2125819
/gene="bfrA"
/gene_synonym="bfr"
/locus_tag="Rv1876"
CDS 2125340..2125819
/codon_start=1
/transl_table=11
/gene="bfrA"
/gene_synonym="bfr"
/locus_tag="Rv1876"
/product="Probable bacterioferritin BfrA"
/note="Rv1876, (MTCY180.42c), len: 159 aa. Probable bfrA
(alternate gene name: bfr), bacterioferritin (see citation
below), similar to BFR_MYCLE|P43315 bacterioferritin (bfr)
from Mycobacterium leprae (159 aa), FASTA results: opt:
958, E(): 0, (90.6% identity in 159 aa overlap). Also
similar to Rv3841|MTCY01A6.28c|bfrB possible
bacterioferritin from Mycobacterium tuberculosis (181 aa).
Belongs to the bacterioferritin family."
/db_xref="EnsemblGenomes-Gn:Rv1876"
/db_xref="EnsemblGenomes-Tr:CCP44642"
/db_xref="GOA:P9WPQ9"
/db_xref="InterPro:IPR002024"
/db_xref="InterPro:IPR008331"
/db_xref="InterPro:IPR009040"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012347"
/db_xref="PDB:2WTL"
/db_xref="PDB:3QB9"
/db_xref="PDB:3UOF"
/db_xref="PDB:3UOI"
/db_xref="UniProtKB/Swiss-Prot:P9WPQ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44642.1"
/translation="MQGDPDVLRLLNEQLTSELTAINQYFLHSKMQDNWGFTELAAHT
RAESFDEMRHAEEITDRILLLDGLPNYQRIGSLRIGQTLREQFEADLAIEYDVLNRLK
PGIVMCREKQDTTSAVLLEKIVADEEEHIDYLETQLELMDKLGEELYSAQCVSRPPT"
gene 2125904..2127967
/locus_tag="Rv1877"
CDS 2125904..2127967
/codon_start=1
/transl_table=11
/locus_tag="Rv1877"
/product="Probable conserved integral membrane protein"
/note="Rv1877, (MTCY180.41c), len: 687 aa. Probable
conserved integral membrane protein, part of major
facilitator superfamily (MFS), similar to many antibiotic
and drug efflux proteins. Similar to e.g. Q56175 TU22
dTDP-glucose dehydrtatase from Streptomyces violaceoruber
(557 aa), FASTA scores: opt: 895, E(): 0, (34.7% identity
in 528 aa overlap). Also similar to Mycobacterium
tuberculosis relatives protein, include Rv3728,
Rv3239c,Rv2846c, etc. Contains PS00217 Sugar transport
proteins signature 2 (PS00217)."
/db_xref="EnsemblGenomes-Gn:Rv1877"
/db_xref="EnsemblGenomes-Tr:CCP44643"
/db_xref="GOA:P9WG85"
/db_xref="InterPro:IPR001411"
/db_xref="InterPro:IPR001958"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WG85"
/inference="protein motif:PROSITE:PS00217"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44643.1"
/translation="MAGPTAPTTAPTAIRAGGPLLSPVRRNIIFTALVFGVLVAATGQ
TIVVPALPTIVAELGSTVDQSWAVTSYLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVF
VVGSVLCGLSQTMTMLAISRALQGVGAGAISVTAYALAAEVVPLRDRGRYQGVLGAVF
GVNTVTGPLLGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDYLGI
LVIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGRAAAAILPPRL
FGSPVFAVCCVLSFVVGFAMLGALTFVPIYLGYVDGASATASGLRTLPMVIGLLIAST
GTGVLVGRTGRYKIFPVAGMALMAVAFLLMSQMDEWTPPLLQSLYLVVLGAGIGLSMQ
VLVLIVQNTSSFEDLGVATSGVTFFRVVGASFGTATFGALFVNFLDRRLGSALTSGAV
PVPAVPSPAVLHQLPQSMAAPIVRAYAESLTQVFLCAVSVTVVGFILALLLREVPLTD
IHDDADDLGDGFGVPRAESPEDVLEIAVRRMLPNGVRLRDIATQPGCGLGVAELWALL
RIYQYQRLFEAVRLTDIGRHLHVPYQVFEPVFDRLVQTGYAARDGDILTLTPSGHRQV
DSLAVLIRQWLLDHLAVAPGLKRQPDHQFEAALQHVTDAVLVQRDWYEDLGDLSESRQ
LAATT"
gene 2128022..2129374
/gene="glnA3"
/locus_tag="Rv1878"
CDS 2128022..2129374
/codon_start=1
/transl_table=11
/gene="glnA3"
/locus_tag="Rv1878"
/product="Probable glutamine synthetase GlnA3 (glutamine
synthase) (GS-I)"
/note="Rv1878, (MTCY180.40c), len: 450 aa. Probable
glnA3,glutamine synthetase class I, similar to many e.g.
GLNA_BACCE|P19064 from Bacillus cereus (443 aa), FASTA
results: opt: 497, E(): 5.2e-23, (29.0% identity in 331 aa
overlap); etc. Also similar to C-terminus of
FLUG_EMENI|P38094 flug protein from emericella nidulans
(865 aa), FASTA scores: opt: 227, E (): 6.4e-13, (29.9%
identity in 394 aa overlap). Note that the downstream ORF
MTCY180.39c is similar to the N-terminus. Also similar to
three other potential glutamine synthases in M.
tuberculosis: Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY1
90.33c|MTCY427 .03c; Rv2860c|MTV003.06c|glnA4 and
Rv2220|glnA1. Belongs to the glutamine synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv1878"
/db_xref="EnsemblGenomes-Tr:CCP44644"
/db_xref="GOA:O07752"
/db_xref="InterPro:IPR008146"
/db_xref="InterPro:IPR014746"
/db_xref="UniProtKB/TrEMBL:O07752"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44644.1"
/translation="MTATPLAAAAIAQLEAEGVDTVIGTVVNPAGLTQAKTVPIRRTN
TFANPGLGASPVWHTFCIDQCSIAFTADISVVGDQRLRIDLSALRIIGDGLAWAPAGF
FEQDGTPVPACSRGTLSRIEAALADAGIDAVIGHEVEFLLVDADGQRLPSTLWAQYGV
AGVLEHEAFVRDVNAAATAAGIAIEQFHPEYGANQFEISLAPQPPVAAADQLVLTRLI
IGRTARRHGLRVSLSPAPFAGSIGSGAHQHFSLTMSEGMLFSGGTGAAGMTSAGEAAV
AGVLRGLPDAQGILCGSIVSGLRMRPGNWAGIYACWGTENREAAVRFVKGGAGSAYGG
NVEVKVVDPSANPYLASAAILGLALDGMKTKAVLPSETTVDPTQLSDVDRDRAGILRL
AADQADAIAVLDSSKLLRCILGDPVVDAVVAVRQLEHERYGDLDPAQLADKFRMAWSV
"
gene 2129377..2130513
/locus_tag="Rv1879"
CDS 2129377..2130513
/codon_start=1
/transl_table=11
/locus_tag="Rv1879"
/product="Conserved hypothetical protein"
/note="Rv1879, (MTCY180.39c), len: 378 aa. Conserved
hypothetical protein, similar to SCC22.14c|AL096839
hypothetical protein from Streptomyces coelicolor (368
aa),FASTA results: opt: 772, E(): 0 (40.3% identity in 372
aa overlap); and to N-terminal half of
nodulin/glutamate-ammonia ligase-like protein. Some
similarity to N-terminus of AL132958|ATT4D2_11 Arabidopsis
thaliana (845 aa), FASTA results: opt: 354, E():
3.1e-16,(29.2% identity in 383 aa overlap); and to
P38094|FLUG_EMENI Flug protein of Emericella nidulans (865
aa), FASTA results: opt: 306, E(): 6.2e-13, (26.5%
identity in 415 aa overlap). Note that the upstream ORF
Rv1878|MTCY18 0.40c is similar to the C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv1879"
/db_xref="EnsemblGenomes-Tr:CCP44645"
/db_xref="GOA:O07751"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/TrEMBL:O07751"
/protein_id="CCP44645.1"
/translation="MADSAGSDLTRHTAEVPLIDQHVHGCWLTEGNRRRFENALNEAN
TEPLADFDSGFDSQLGFAVRNHCAPILGLPRHVDPQTYWDRRSQFSEAELARRFLQAA
GVTDWLVETGIGYDVSGMASVAGLGELSGSHAHEVVRLEQVAEQAVQASGDYASAFNE
ILRRRAATAVATKSILAYRGGFDGDLTEPPAAQVAEAAKRWRDRGGVRLQDRVLLRFG
LHQALRLGKPLQFHVGFGDRDADLHKANPLYLLDFLRQSGNTPIVLLHCYPYEREAGY
LAQAFNNVYLDGGLSVHYLGARSPAFIGRLLELAPFRKIVYSSDGFGPAELHFLGATL
WRSGIQRVLRGFVERDDWCETDALRVVDLIAHGTAARIYRLGDR"
gene complement(2130541..2131857)
/gene="cyp140"
/locus_tag="Rv1880c"
CDS complement(2130541..2131857)
/codon_start=1
/transl_table=11
/gene="cyp140"
/locus_tag="Rv1880c"
/product="Probable cytochrome P450 140 Cyp140"
/note="Rv1880c, (MT1929, MTCY180.38), len: 438 aa.
Probable cyp140, cytochrome p450. Similar to
Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase
(404 aa), FASTA scores: opt: 775, E(): 0, (44.2% identity
in 319 aa overlap); and other members of the cytochrome
P450 family. Related to Mycobacterium tuberculosis
proteins include: Rv0766c, Rv2266, Rv0778, etc. Contains
cytochrome P450 cysteine heme-iron ligand signature
(PS00086). Belongs to the cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv1880c"
/db_xref="EnsemblGenomes-Tr:CCP44646"
/db_xref="GOA:P9WPL9"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPL9"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44646.1"
/translation="MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPF
YDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQ
LHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIV
DVVGRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRG
FDCWLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV
NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR
IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGE
VGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP"
gene complement(2131907..2132329)
/gene="lppE"
/locus_tag="Rv1881c"
CDS complement(2131907..2132329)
/codon_start=1
/transl_table=11
/gene="lppE"
/locus_tag="Rv1881c"
/product="Possible conserved lipoprotein LppE"
/note="Rv1881c, (MTCY180.37), len: 140 aa. Possible
lppE,lipoprotein, showing some similarity to
L12238|MSG18S19K_1 19K antigen from Mycobacterium
intracellulare (162 aa),FASTA scores: opt: 137, E():
0.0069, (27.6% identity in 156 aa overlap). Contains
signal sequence and appropriately positioned PS00013
Prokaryotic membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1881c"
/db_xref="EnsemblGenomes-Tr:CCP44647"
/db_xref="GOA:O07750"
/db_xref="InterPro:IPR008691"
/db_xref="UniProtKB/Swiss-Prot:O07750"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44647.1"
/translation="MCNRLVTVTGVAMVVAAGLSACGQAQTVPRKAARLTIDGVTHTT
RPATCSQEHSYRTIDIRNHDSTVQAVVLLSGDRVIPQWVKIRNVDGFNGSFWHGGVGN
ARADRARNTYTVAGSAYGISSKKPNTVVSTDFNILAEC"
gene complement(2132370..2133203)
/locus_tag="Rv1882c"
CDS complement(2132370..2133203)
/codon_start=1
/transl_table=11
/locus_tag="Rv1882c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv1882c, (MTCY180.36), len: 277 aa. Probable
short-chain dehydrogenase/reductase, similar to various
dehydrogenases/reductases, generally belonging to SDR
family, e.g. NP_250789.1|NC_002516 probable short-chain
dehydrogenase from Pseudomonas aeruginosa (251 aa);
NP_421760.1|NC_002696 short chain dehydrogenase family
protein from Caulobacter crescentus (270 aa);
NP_107167.1|NC_002678 oxidoreductase (short chain
dehydrogenase/reductase family) from Mesorhizobium loti
(253 aa); P50197|LINC_PSEPA
2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase
from Pseudomonas paucimobilis (Sphingomonas paucimobilis)
(250 aa), FASTA scores: opt: 301, E(): 2.3e-12, (30.0%
identity in 223 aa overlap); etc. Also similar to proteins
from Mycobacterium tuberculosis e.g. Rv3057c, Rv1245, etc.
Contains possible helix-turn-helix motif at aa 246-267
(+4.32 SD). Contains PS00061 Short-chain alcohol
dehydrogenase family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1882c"
/db_xref="EnsemblGenomes-Tr:CCP44648"
/db_xref="GOA:O07749"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O07749"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44648.1"
/translation="MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALRVQ
LGAERLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGEGGWFEDVPYEAA
VRVVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSSGTYGMPRIAVYSATKHAVKGL
TEALSVEWQRHGVRVADVLPGLIDTAILTSTRQHSDEGPYTISAEQIRAAAPKKGMFR
LMPSSSVAEAAWRAYQHPTRLHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKR
K"
gene complement(2133231..2133692)
/locus_tag="Rv1883c"
CDS complement(2133231..2133692)
/codon_start=1
/transl_table=11
/locus_tag="Rv1883c"
/product="Conserved hypothetical protein"
/note="Rv1883c, (MTCY180.35), len: 153 aa. Conserved
hypothetical protein, some similarity to hypothetical
proteins e.g. Rv2778c|AL008967|MTV002.43 from
Mycobacterium tuberculosis (156 aa), FASTA score: opt:
212, E(): 3.1e-08,(34.4% identity in 151 aa overlap). Also
similar to U75434|SAU75434_3 Nsh-OrfB from Streptomyces
actuosus (173 aa), FASTA score: opt: 207, E(): 1.8e-07,
(40.2% identity in 102 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1883c"
/db_xref="EnsemblGenomes-Tr:CCP44649"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O07748"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44649.1"
/translation="MCLDQVMEGSATVHMAAPPDKIWTLIADVRNTGRFSPETFEAEW
LDGATGPALGARFRGHVRRNGIGPVYWTVCEPGREFGFAVLLGDRPVNNWHYRLTPTA
DGTEVTESFRLPPSVLTTVYYRVFGGWLRQRRNIRDMTKTLQRIKDLVEAG"
gene complement(2133731..2134261)
/gene="rpfC"
/locus_tag="Rv1884c"
CDS complement(2133731..2134261)
/codon_start=1
/transl_table=11
/gene="rpfC"
/locus_tag="Rv1884c"
/product="Probable resuscitation-promoting factor RpfC"
/note="Rv1884c, (MTCY180.34), len: 176 aa. Probable
rpfC,resuscitation promoting factor (see citation
below),similar to Z96935|MLRPF_1 resusicitation-promoting
factor from Micrococcus luteus (220 aa), FASTA score: opt:
287,E() : 3.3e-11, (40.0% identity in 120 aa overlap).
Also similar to others from Mycobacterium tuberculosis:
Rv2389c|MTCY253.32|RPFD probable resuscitation-promoting
factor (154 aa), FASTA score: opt: 382, E():
7.1e-17,(55.4% identity in 101 aa overlap); Rv0867c|RPFA
(N-terminal part), Rv2450c|RPFE, and Rv1009|RPFB
(C-terminal part). Predicted possible vaccine candidate
(See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1884c"
/db_xref="EnsemblGenomes-Tr:CCP44650"
/db_xref="GOA:O07747"
/db_xref="InterPro:IPR010618"
/db_xref="InterPro:IPR023346"
/db_xref="PDB:2N5Z"
/db_xref="PDB:4OW1"
/db_xref="UniProtKB/Swiss-Prot:O07747"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44650.1"
/translation="MHPLPADHGRSRCNRHPISPLSLIGNASATSGDMSSMTRIAKPL
IKSAMAAGLVTASMSLSTAVAHAGPSPNWDAVAQCESGGNWAANTGNGKYGGLQFKPA
TWAAFGGVGNPAAASREQQIAVANRVLAEQGLDAWPTCGAASGLPIALWSKPAQGIKQ
IINEIIWAGIQASIPR"
gene complement(2134273..2134872)
/gene_synonym="*MtCM"
/locus_tag="Rv1885c"
CDS complement(2134273..2134872)
/codon_start=1
/transl_table=11
/gene_synonym="*MtCM"
/locus_tag="Rv1885c"
/product="Chorismate mutase"
/note="Rv1885c, (MTCY180.33), len: 199 aa. Chorismate
mutase, AroQ class (See Prakash et al., 2005, Sasso et
al.,2005), some similarity to P42517|CHMU_ERWHE
monofunctional chorismate mutase (181 aa), FASTA score:
opt: 181, E(): 0.00017, (28.6% identity in 133 aa
overlap). Contains N-terminal signal sequence."
/db_xref="EnsemblGenomes-Gn:Rv1885c"
/db_xref="EnsemblGenomes-Tr:CCP44651"
/db_xref="GOA:P9WIB9"
/db_xref="InterPro:IPR002701"
/db_xref="InterPro:IPR008240"
/db_xref="InterPro:IPR036263"
/db_xref="PDB:2AO2"
/db_xref="PDB:2F6L"
/db_xref="PDB:2FP1"
/db_xref="PDB:2FP2"
/db_xref="UniProtKB/Swiss-Prot:P9WIB9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44651.1"
/translation="MLTRPREIYLATAVSIGILLSLIAPLGPPLARADGTSQLAELVD
AAAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDARSQHIDPDYVTRVFDDQI
RATEAIEYSRFSDWKLNPASAPPEPPDLSASRSAIDSLNNRMLSQIWSHWSLLSAPSC
AAQLDRAKRDIVRSRHLDSLYQRALTTATQSYCQALPPA"
gene complement(2134890..2135867)
/gene="fbpB"
/gene_synonym="85B"
/gene_synonym="mpt59"
/locus_tag="Rv1886c"
CDS complement(2134890..2135867)
/codon_start=1
/transl_table=11
/gene="fbpB"
/gene_synonym="85B"
/gene_synonym="mpt59"
/locus_tag="Rv1886c"
/product="Secreted antigen 85-B FbpB (85B) (antigen 85
complex B) (mycolyl transferase 85B) (fibronectin-binding
protein B) (extracellular alpha-antigen)"
/note="Rv1886c, (MT1934, MTCY180.32), len: 325 aa. FbpB
(alternate gene names: mpt59, 85B), precursor of the 85-B
antigen (fibronectin-binding protein B) (mycolyl
transferase 85B) (see citations below), highly similar to
other Mycobacterial antigen precursors e.g.
P12942|A85B_MYCBO antigen 85-B precursor from
Mycobacterium bovis (323 aa); P21160|A85B_MYCKA antigen
85-B precursor from Mycobacterium kansasii (325 aa); etc.
Also highly similar to Mycobacterium tuberculosis antigen
precursors: Rv3804c|fbpA (338 aa), Rv0129c|fbpC2 (340 aa),
and Rv3803c|fbpC1 (299 aa). Predicted possible vaccine
candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1886c"
/db_xref="EnsemblGenomes-Tr:CCP44652"
/db_xref="GOA:P9WQP1"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:1F0N"
/db_xref="PDB:1F0P"
/db_xref="PDB:5TRZ"
/db_xref="PDB:5TS1"
/db_xref="UniProtKB/Swiss-Prot:P9WQP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44652.1"
/translation="MTDVSRKIRAWGRRLMIGTAAAVVLPGLVGLAGGAATAGAFSRP
GLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYY
QSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGS
AAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAAD
MWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSS
NLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG"
gene 2136258..2137400
/locus_tag="Rv1887"
CDS 2136258..2137400
/codon_start=1
/transl_table=11
/locus_tag="Rv1887"
/product="Hypothetical protein"
/note="Rv1887, (MTCY180.31), len: 380 aa. Hypothetical
unknown protein; contains eukaryotic thiol (cysteine)
proteases histidine active site at N-terminus (PS00639)
and Pro-rich region near C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv1887"
/db_xref="EnsemblGenomes-Tr:CCP44653"
/db_xref="GOA:O07745"
/db_xref="UniProtKB/TrEMBL:O07745"
/inference="protein motif:PROSITE:PS00639"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44653.1"
/translation="MDTVLGLSITPTTLGWVLAEGHGADGAILDRNELELHSGRNAQA
IHTAEQLAAEVLLAHEVAAAGDHRLRVIGVTWNAEASAQAALLVESLTGAGFDNVVPV
RRLRAIETLAQAIAPVIGYEQIAVCVLEHESATVVMVDTHDGKTQIAVKHVCRGLSGL
TSWLTGMFGRDAWRPAGVVVVGSDSEVSEFSWQLERVLPVPVFAQTMAQVTVARGAAL
AAAQSTEFTDAQLVADSVSQPTVAPRRSRHYAGAAAALAAAAVTFVASLSLAVGIQLA
PHNDTGTAKHGAHKPTPRIAKAVAPAVPPPPTVTPPVPARAPRPAAQHEPPARVTSGE
ALTEPNPPEEQPNASAPQQDRNDSQPITRVLEHIPGAYGDSAPPAE"
gene complement(2137519..2138079)
/locus_tag="Rv1888c"
CDS complement(2137519..2138079)
/codon_start=1
/transl_table=11
/locus_tag="Rv1888c"
/product="Possible transmembrane protein"
/note="Rv1888c, (MTCY180.30), len: 186 aa. Possible
transmembrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1888c"
/db_xref="EnsemblGenomes-Tr:CCP44654"
/db_xref="GOA:O07744"
/db_xref="InterPro:IPR025498"
/db_xref="UniProtKB/TrEMBL:O07744"
/protein_id="CCP44654.1"
/translation="MQPDAYPVRVRGDLDPALSRWQWLVKWFLAIPHYIVLFFLHVAA
VVVTVIAFFAILFTGRYPRTLFDFNVGVMRWRWRVAFYALSALGTDRYPPFSLQTKAE
YPADLEVDYPERLSRGLVLIKWWLLAIPHYLILAVFLSSGWRVFLIDPHDRVGIMWPS
LLVILLLVAVVALLFTGRYPIGLYNL"
gene complement(2138444..2138617)
/locus_tag="Rv1888A"
CDS complement(2138444..2138617)
/codon_start=1
/transl_table=11
/locus_tag="Rv1888A"
/product="Conserved hypothetical protein"
/note="Rv1888A, len: 57 aa. Conserved hypothetical
protein. Possibly continuation of Rv1889c, part of large
family of Mycobacterium tuberculosis proteins with
conserved N-terminal domain of ~ 120 aa. Includes:
C-terminus of Rv0726c|P95074 conserved hypothetical
protein (367 aa),FASTA scores: opt: 295, E(): 3.1e-15,
(73.684% identity in 57 aa overlap); C-terminus of
Rv3399|Q50726|MTCY78.29c conserved hypothetical protein
(348 aa), FASTA scores: opt: 504, E(): 7.3e-29, (64.2%
identity in 120 aa overlap); C-terminus of Rv0731c; etc."
/db_xref="EnsemblGenomes-Gn:Rv1888A"
/db_xref="EnsemblGenomes-Tr:CCP44655"
/db_xref="GOA:Q79FJ0"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:Q79FJ0"
/protein_id="CCP44655.1"
/translation="MVPVDLRRDWPTPLRQAGFDPNQPSAWLAEGLLAFLPPDAQDRL
LDNITALSAPGSR"
gene complement(2138661..2139017)
/locus_tag="Rv1889c"
CDS complement(2138661..2139017)
/codon_start=1
/transl_table=11
/locus_tag="Rv1889c"
/product="Conserved hypothetical protein"
/note="Rv1889c, (MTCY180.29), len: 118 aa. Conserved
hypothetical protein. Part of large family of
Mycobacterium tuberculosis proteins with conserved
N-terminal domain of ~120 aa. Includes:
Rv3399|Q50726|MTCY78.29C conserved hypothetical protein
(348 aa), FASTA results: opt: 504,E(): 7.3e-29, (64.2%
identity in 120 aa overlap); Rv0726c|P95074; Rv0731c; etc.
Rv1888A possibly continuation of this CDS."
/db_xref="EnsemblGenomes-Gn:Rv1889c"
/db_xref="EnsemblGenomes-Tr:CCP44656"
/db_xref="GOA:O07743"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O07743"
/protein_id="CCP44656.1"
/translation="MPRTNNDAWDLATSVGATATMVAAARAVATRADNPLIDDPFAEP
LVRAVGIDFFTRWAAGNIKATDVDDPDGTWGLQRLADLLAARTRYFDAFFRDATSAGI
RQAVILASGLDARAYR"
gene complement(2139076..2139687)
/locus_tag="Rv1890c"
CDS complement(2139076..2139687)
/codon_start=1
/transl_table=11
/locus_tag="Rv1890c"
/product="Hypothetical protein"
/note="Rv1890c, (MTCY180.28), len: 203 aa. Hypothetical
unknown protein. Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1890c"
/db_xref="EnsemblGenomes-Tr:CCP44657"
/db_xref="GOA:O07742"
/db_xref="InterPro:IPR007372"
/db_xref="InterPro:IPR036761"
/db_xref="UniProtKB/TrEMBL:O07742"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44657.1"
/translation="MAHKTRREGRAGRSSEYSRGVSDAVWTLDASDGELVLRTGVVGR
AARLGHRLTIAMTRWQALVNWSGTDPVAGELVAEVDSFEVMRGEGGVKGLSEPEKALV
RANALKTLNASRFPHIRFTTEAIAQTGNGYRLTGKLHIRGKSREHVIDLHTEDLGAAW
RISADTTVRQSNYGVKPYSLLMGSIRVADEVSVAFTAVRAKDD"
gene 2139419..2139656
/gene="AS1890"
ncRNA 2139419..2139656
/gene="AS1890"
/product="Putative small regulatory RNA"
/note="AS1890, putative small regulatory RNA (See Arnvig
and Young, 2009). Alternate 5'-ends at positions
2139466,2139548, 2139594."
/ncRNA_class="other"
gene 2139741..2140148
/locus_tag="Rv1891"
CDS 2139741..2140148
/codon_start=1
/transl_table=11
/locus_tag="Rv1891"
/product="Conserved protein"
/note="Rv1891, (MTCY180.27c), len: 135 aa. Conserved
protein. Equivalent to MLCB561.09|AL049571 hypothetical
protein from Mycobacterium leprae (134 aa), FASTA scores:
opt: 800, E(): 0, (79.7% identity in 133 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1891"
/db_xref="EnsemblGenomes-Tr:CCP44658"
/db_xref="GOA:O07741"
/db_xref="UniProtKB/TrEMBL:O07741"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44658.1"
/translation="MIRELVTTAAITGAAIGGAPVAGADPQRYDGDVPGMNYDASLGA
PCSSWERFIFGRGPSGQAEACHFPPPNQFPPAETGYWVISYPLYGVQQVGAPCPKPQA
AAQSPDGLPMLCLGARGWQPGWFTGAGFFPPEP"
gene 2140165..2140476
/locus_tag="Rv1892"
CDS 2140165..2140476
/codon_start=1
/transl_table=11
/locus_tag="Rv1892"
/product="Probable membrane protein"
/note="Rv1892, (MTCY180.26c), len: 103 aa. Probable
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv1892"
/db_xref="EnsemblGenomes-Tr:CCP44659"
/db_xref="GOA:O07740"
/db_xref="UniProtKB/TrEMBL:O07740"
/protein_id="CCP44659.1"
/translation="MIMCEGRPTESPIPRWLRFVLTSDRAGSAWYIGAGFFFAPVLAV
LSPWPTITAVLWWIIGLAGLWLGLLGIAMAVGLARVLRSGAEIPEAYWRTLVDYRSAN
E"
gene 2140486..2140704
/locus_tag="Rv1893"
CDS 2140486..2140704
/codon_start=1
/transl_table=11
/locus_tag="Rv1893"
/product="Conserved hypothetical protein"
/note="Rv1893, (MTCY180.25c), len: 72 aa. Conserved
hypothetical protein. Equivalent to MLCB561.11|AL049571
hypothetical protein from Mycobacterium leprae (74
aa),FASTA scores: opt: 317, E(): 4.6e-15, (69.4% identity
in 72 aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv1893"
/db_xref="EnsemblGenomes-Tr:CCP44660"
/db_xref="UniProtKB/TrEMBL:O07739"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44660.1"
/translation="MSFNPKDAVDAVRDIAANAVEKASDIVENAGHIIRGDIAGGASG
IVKDSIDIATHAVDRTKEVFTGKTDDEG"
gene complement(2140739..2141869)
/locus_tag="Rv1894c"
CDS complement(2140739..2141869)
/codon_start=1
/transl_table=11
/locus_tag="Rv1894c"
/product="Conserved hypothetical protein"
/note="Rv1894c, (MTCY180.24), len: 376 aa. Conserved
hypothetical protein, weak similarity to some
oxidoreductases e.g. Q01284 2-nitropropane dioxygenase
precursor (378 aa), FASTA results: opt: 204, E():
5.8e-06,(34.3% identity in 140 aa overlap). Similar to
hypothetical Mycobacterium tuberculosis proteins e.g.
Rv3553|MTCY03C7.02c (355 aa), FASTA results: opt: 296,
E(): 1.6e-10, (32.9% identity in 167 aa overlap); Rv1533
(375 aa) (48.1% identity in 376 aa overlap); Rv0021c,
Rv2781c."
/db_xref="EnsemblGenomes-Gn:Rv1894c"
/db_xref="EnsemblGenomes-Tr:CCP44661"
/db_xref="GOA:O07738"
/db_xref="InterPro:IPR004136"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:O07738"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44661.1"
/translation="MHTAICDELGIEFPIFAFTHCRDVVVAVSKAGGFGVLGAVGFTP
EQLEIELNWIDEHIGDHPYGVDIVIPNKYEGMDSQLSADELAKTLRSMVPQEHLDFAR
KILADHGVPVEDADEDSLQLLGWTEATATPQVDAALKHPKMTMVANALGTPPADMIKH
IHDSGRKVAALCGSPSQARKHADAGVDIIIAQGGEAGGHCGEVGSIVLWPQVVKEVAP
VPVLAAGGIGSGQQIAAALALGTQGAWTGSQWLMVEEAANTAVQQAAYVKATSRDTVR
SRSFTGKPARMLRNDWTEAWEQPESPKPLGMPLQYMVSGMAVKATHKYPNETVDVAFN
PVGQVVGQFTKVEKTATVIERWVQEYLEATARLDALNAAASV"
gene 2142521..2143675
/locus_tag="Rv1895"
CDS 2142521..2143675
/codon_start=1
/transl_table=11
/locus_tag="Rv1895"
/product="Possible dehydrogenase"
/note="Rv1895, (MTCY180.23c), len: 384 aa. Possible
dehydrogenase, similar to various sorbitol and alcohol
dehydrogenases, and to putative glutathione-dependent
aldehyde dehydrogenase e.g DHSO_BACSU|Q06004 Sorbitol
dehydrogenase from Streptomyces coelicolor (352 aa), FASTA
results: opt: 506, E(): 7.2e-24, (30.6% identity in 350 aa
overlap); and AL109962|SCJ1.28 putative zinc-containing
dehydrogenase from Streptomyces coelicolor (356 aa), FASTA
results: opt: 634, E(): 2.9e-30, (34.7% identity in 357 aa
overlap). Also similar to other Mycobacterium tuberculosis
dehydrogenases. Note that there is a substantial (134 bp)
overlap at the C-terminus with the C-terminus of the
downstream ORF, although both appear to be true coding
regions."
/db_xref="EnsemblGenomes-Gn:Rv1895"
/db_xref="EnsemblGenomes-Tr:CCP44662"
/db_xref="GOA:O07737"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:O07737"
/protein_id="CCP44662.1"
/translation="MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHF
YEGEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCETHDPVM
CFSGPMIFGAGVLGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR
ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPSPA
AETILAATRGRGADSVIDAVGTDASMSDALNAVRPGGTVSVVGVHDLQPFPVPALTCL
LRSITLRMTMAPVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEE
LRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN"
gene complement(2143535..2144446)
/locus_tag="Rv1896c"
CDS complement(2143535..2144446)
/codon_start=1
/transl_table=11
/locus_tag="Rv1896c"
/product="Conserved hypothetical protein"
/note="Rv1896c, (MTCY180.22), len: 303 aa. Conserved
hypothetical protein. Similar to several (14) hypothetical
Mycobacterium tuberculosis proteins e.g. Rv0145|MTCI5.19
(317 aa), FASTA results: opt: 720, E(): 0, (41.6% identity
in 308 aa overlap); Q10552|YZ21_MYCTU (325 aa), opt:
689,E(): 0, (40.5% identity in 304 aa overlap);
Rv0726c,Rv0731c, Rv3399, etc. and to related proteins in
other actinomycetes. Note that there is a substantial (134
bp) overlap at the C-terminus with the C-terminus of the
downstream ORF, although both appear to be true coding
regions."
/db_xref="EnsemblGenomes-Gn:Rv1896c"
/db_xref="EnsemblGenomes-Tr:CCP44663"
/db_xref="GOA:P9WFH7"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFH7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44663.1"
/translation="MTTPEYGSLRSDDDHWDIVSNVGYTALLVAGWRALHTTGPKPLV
QDEYAKHFITASADPYLEGLLANPRTSEDGTAFPRLYGVQTRFFDDFFNCADEAGIRQ
AVIVAAGLDCRAYRLDWQPGTTVFEIDVPKVLEFKARVLSERGAVPKAHRVAVPADLR
TDWPTPLTAAGFDPQRPSAWSVEGLLPYLTGDAQYALFARIDELCAPGSRVALGALGS
RLDHEQLAALETAHPGVNMSGDVNFSALTYDDKTDPVEWLVEHGWAVDPVRSTLELQV
GYGLTPPDVDVKIDSFMRSQYITAVRA"
gene complement(2144451..2144882)
/locus_tag="Rv1897c"
CDS complement(2144451..2144882)
/codon_start=1
/transl_table=11
/locus_tag="Rv1897c"
/product="Conserved hypothetical protein"
/note="Rv1897c, (MTCY180.21), len: 143 aa. Conserved
hypothetical protein. Some similarity to D63706|Q54235
ORF2 from Streptomyces griseus (149 aa), FASTA results:
opt: 509, E(): 1.2e-28, (57.3% identity in 150 aa
overlap); and Q45303 ORF1 protein from Corynebacterium
glutamicum (144 aa), FASTA results: opt: 460, E():
5.5e-23, (49.7% identity in 143 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1897c"
/db_xref="EnsemblGenomes-Tr:CCP44664"
/db_xref="GOA:P9WNS9"
/db_xref="InterPro:IPR003732"
/db_xref="InterPro:IPR023509"
/db_xref="UniProtKB/Swiss-Prot:P9WNS9"
/protein_id="CCP44664.1"
/translation="MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDK
ARRLAEKLWNLRVLADEKSASDMHAPILVISQFTLYADTAKGRRPSWNAAAPGAVAQP
LIAAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG"
gene 2144940..2145248
/locus_tag="Rv1898"
CDS 2144940..2145248
/codon_start=1
/transl_table=11
/locus_tag="Rv1898"
/product="Conserved hypothetical protein"
/note="Rv1898, (MTCY180.20c), len: 102 aa. Conserved
hypothetical protein, some similarity to other
hypothetical proteins e.g. Q58452 from methanococcus
jannasch II (100 aa), FASTA results: opt: 152, E():
9.1e-05, (31.5% identity in 92 aa overlap); and
AE000771|AE000771_2 from Aquifex aeolicus (157 aa), FASTA
results: opt: 246, E(): 3.2e-11,(39.0% identity in 100 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1898"
/db_xref="EnsemblGenomes-Tr:CCP44665"
/db_xref="InterPro:IPR002767"
/db_xref="InterPro:IPR029756"
/db_xref="UniProtKB/Swiss-Prot:P9WFQ1"
/protein_id="CCP44665.1"
/translation="MSVLVAFSVTPLGVGEGVGEIVTEAIRVVRDSGLPNQTDAMFTV
IEGDTWAEVMAVVQRAVEAVAARAPRVSAVIKVDWRPGVTDAMTQKVATVERYLLRPE
"
gene complement(2145214..2146245)
/gene="lppD"
/locus_tag="Rv1899c"
CDS complement(2145214..2146245)
/codon_start=1
/transl_table=11
/gene="lppD"
/locus_tag="Rv1899c"
/product="Possible lipoprotein LppD"
/note="Rv1899c, (MTCY180.19), len: 343 aa. Possible
lipoprotein; contains appropriately localized lipoprotein
lipid attachment site (PS00013). Some similarity to
C-terminal part of AE000717|AE000717_4 hypothetical
protein from Aquifex aeolicus section 49 (165 aa), FASTA
results: opt: 372, E(): 2.3e-14, (43.5% identity in 147 aa
overlap); and Q44020 4-hydroxybutyrate dehydrogenase (173
aa), FASTA results: opt: 272, E(): 4.7e-09, (35.8%
identity in 165 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1899c"
/db_xref="EnsemblGenomes-Tr:CCP44666"
/db_xref="GOA:P9WK29"
/db_xref="InterPro:IPR002589"
/db_xref="UniProtKB/Swiss-Prot:P9WK29"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44666.1"
/translation="MSRAAGLPRLSWFAGLTWFAGGSTGAGCAAHPALAGLTAGARCP
AYAAISASTARPAATAGTTPATGASGSARPTDAAGMADLARPGVVATHAVRTLGTTGS
RAIGLCPCQPLDCPRSPQATLNLGSMGRSLDGPQWRRARVRLCGRWWRRSNTTRGASP
RPPSTCRGDNVSMIELEVHQADVTKLELDAITNAANTRLRHAGGVAAAIARAGGPELQ
RESTEKAPIGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAATAATLRKADEL
GCRSLALVAFGTGVGGFPLDDAARLMVGAVRRHRPGSLQRVVFAVHGDAAERAFSAAI
QAGEDTARR"
gene complement(2146245..2147633)
/gene="lipJ"
/locus_tag="Rv1900c"
CDS complement(2146245..2147633)
/codon_start=1
/transl_table=11
/gene="lipJ"
/locus_tag="Rv1900c"
/product="Probable lignin peroxidase LipJ"
/note="Rv1900c, (MTCY180.18), len: 462 aa. Probable
lipJ,lignin peroxidase, with some similarity to
esterases,hydrolases and hypothetical Mycobacterium
tuberculosis proteins e.g. Q43936 beta-ketoadipate
enol-lactone hydrolase from Acinetobacter calcoaceticus
(267 aa), FASTA results: opt: 217, E(): 1.7e-07, (29.2%
identity in 260 aa overlap). Also similar to other
Mycobacterium tuberculosis hypothetical proteins e.g.
Rv2212|Q10400|YM12_MYCTU (378 aa), FASTA results: opt:
216, E(): 6.7e-07, (27.7% identity in 285 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1900c"
/db_xref="EnsemblGenomes-Tr:CCP44667"
/db_xref="GOA:O07732"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR029787"
/db_xref="PDB:1YBT"
/db_xref="PDB:1YBU"
/db_xref="UniProtKB/TrEMBL:O07732"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44667.1"
/translation="MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDS
IDDEPSLYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAVGC
EQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARPLWAPDYPVGAQVRRADPFLT
VALEPDAVERGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVR
DVLGHIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLD
EIEEFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQ
RFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASH
GTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRL
CVLMRDDATRTR"
gene 2147662..2148954
/gene="cinA"
/locus_tag="Rv1901"
CDS 2147662..2148954
/codon_start=1
/transl_table=11
/gene="cinA"
/locus_tag="Rv1901"
/product="Probable CinA-like protein CinA"
/note="Rv1901, (MTCY180.17c), len: 430 aa. Probable
cinA-like protein, strong similarity to competence damage
proteins CinA of Bacillus subtilis and S. pneumoniae.
FASTA results: Q55760 hypothetical 44.7 kDa protein (416
aa) opt: 755, E(): 0, (36.0% identity in 433 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1901"
/db_xref="EnsemblGenomes-Tr:CCP44668"
/db_xref="GOA:P9WPE3"
/db_xref="InterPro:IPR001453"
/db_xref="InterPro:IPR008135"
/db_xref="InterPro:IPR008136"
/db_xref="InterPro:IPR036425"
/db_xref="InterPro:IPR036653"
/db_xref="UniProtKB/Swiss-Prot:P9WPE3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44668.1"
/translation="MAVSARAGIVITGTEVLTGRVQDRNGPWIADRLLELGVELAHIT
ICGDRPADIEAQLRFMAEQGVDLIVTSGGLGPTADDMTVEVVARYCGRELVLDDELEN
RIANILKKLMGRNPAIEPANFDSIRAANRKQAMIPAGSQVIDPVGTAPGLVVPGRPAV
MVLPGPPRELQPIWSKAIQTAPVQDAIAGRTTYRQETIRIFGLPESSLADTLRDAEAA
IPGFDLVEITTCLRRGEIEMVTRFEPNAAQVYTQLARLLRDRHGHQVYSEDGASVDEL
VAKLLTGRRIATAESCTAGLLAARLTDRPGSSKYVAGAVVAYSNEAKAQLLGVDPALI
EAHGAVSEPVAQAMAAGALQGFGADTATAITGIAGPSGGTPEKPVGTVCFTVLLDDGR
TTTRTVRLPGNRSDIRERSTTVAMHLLRRTLSGIPGSP"
gene complement(2149006..2150274)
/gene="nanT"
/locus_tag="Rv1902c"
CDS complement(2149006..2150274)
/codon_start=1
/transl_table=11
/gene="nanT"
/locus_tag="Rv1902c"
/product="Probable sialic acid-transport integral membrane
protein NanT"
/note="Rv1902c, (MTCY180.16), len: 422 aa. Probable
nanT,sialic acid-transport integral membrane protein,
possibly member of major facilitator superfamily (MFS),
similar to others e.g. Q48076 sialic acid transporter (407
aa), FASTA results: opt: 443, E(): 5.4e-22, (26.7%
identity in 389 aa overlap); etc. Some similarity to
MTCI364.12|O05301 conserved hypothetical protein from
Mycobacterium tuberculosis (425 aa), FASTA results: opt:
251, E(): 1.1e-09, (23.5% identity in 417 aa overlap).
Contains sugar transport proteins signature 2 (PS00217)."
/db_xref="EnsemblGenomes-Gn:Rv1902c"
/db_xref="EnsemblGenomes-Tr:CCP44669"
/db_xref="GOA:O07730"
/db_xref="InterPro:IPR004742"
/db_xref="InterPro:IPR005828"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O07730"
/inference="protein motif:PROSITE:PS00217"
/protein_id="CCP44669.1"
/translation="MAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHH
TKTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPLMVDVSFYSVIGFLCAFAPNFTV
LVILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVM
NWLGLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIV
RRFVYLVLLMTAFNWMSHGTQDVYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGG
LAFGTLSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSFLMQVFVQGAWGVIP
AHLTEMSPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVV
AVLTAIGKDATGIRFGTTETAFLVRHRNRH"
gene 2150364..2150768
/locus_tag="Rv1903"
CDS 2150364..2150768
/codon_start=1
/transl_table=11
/locus_tag="Rv1903"
/product="Probable conserved membrane protein"
/note="Rv1903, (MTCY180.15c), len: 134 aa. Probable
conserved membrane protein, similar to Q53868|YPT3_STRCO
hypothetical 15.9 kDa protein from Streptomyces coelicolor
(148 aa) opt: 323, E(): 1.3e-16, (42.9% identity in 126 aa
overlap); and equivalent to AJ000521|MLCOSL672_3 from
Mycobacterium leprae (139 aa), FASTA results: opt:
680,E(): 0, (80.6% identity in 129 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1903"
/db_xref="EnsemblGenomes-Tr:CCP44670"
/db_xref="GOA:O07729"
/db_xref="InterPro:IPR007165"
/db_xref="UniProtKB/TrEMBL:O07729"
/protein_id="CCP44670.1"
/translation="MVPFLMRAAVTGFALWVVTLFVPGMRFAGGDTTLQRVAIIFVVA
VIFGLVNAFIKPIVQILSIPLYILTLGLFHVVVNASMLWLTAWITEHTTHWGLQIDHF
WWTAIWAAILLSIVSWILSLLARDFRRVTRAH"
gene 2150954..2151385
/locus_tag="Rv1904"
CDS 2150954..2151385
/codon_start=1
/transl_table=11
/locus_tag="Rv1904"
/product="Conserved hypothetical protein"
/note="Rv1904, (MTCY180.14c), len: 143 aa. Conserved
hypothetical protein, some similarity to other
hypothetical Mycobacterium tuberculosis proteins e.g.
Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt:
456,E(): 2.7e-23, (52.8% identity in 125 aa overlap);
Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E():
1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c.
Also weak similarity to Q9WVX8|RSBV_STRCO anti-sigma B
factor antagonist from Streptomyces coelicolor (113 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1904"
/db_xref="EnsemblGenomes-Tr:CCP44671"
/db_xref="GOA:O07728"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR003658"
/db_xref="InterPro:IPR036513"
/db_xref="UniProtKB/TrEMBL:O07728"
/protein_id="CCP44671.1"
/translation="MRTVAIGPGAGPSSTRPSSQPSDLHSGLRAVTECTGSAVVVHVG
GDIDASNEVAWQRLVSKSAAIAIAPGPFVIDIRDLDFMGSCAYAVLAQESVRCRRRGV
NMRLVSNQPIVARTIAACGLRRLIPLYATVETALAPPPSAH"
gene complement(2151433..2152395)
/gene="aao"
/locus_tag="Rv1905c"
CDS complement(2151433..2152395)
/codon_start=1
/transl_table=11
/gene="aao"
/locus_tag="Rv1905c"
/product="Probable D-amino acid oxidase Aao"
/note="Rv1905c, (MTCY180.13), len: 320 aa. Probable
aao,D-amino acid oxidase, similar to many. Equivalent to
AJ000521|MLCOSL672.02|O33145 Mycobacterium leprae (320
aa),FASTA results: opt: 1541, E(): 0, (71.7% identity in
315 aa overlap); also similar to OXDD_BOVIN|P31228
d-aspartate oxidase from bos taurus (338 aa), FASTA
results: opt: 461,E(): 1.1e-21, (31.8% identity in 321 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1905c"
/db_xref="EnsemblGenomes-Tr:CCP44672"
/db_xref="GOA:P9WP27"
/db_xref="InterPro:IPR006076"
/db_xref="InterPro:IPR023209"
/db_xref="UniProtKB/Swiss-Prot:P9WP27"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44672.1"
/translation="MAIGEQQVIVIGAGVSGLTSAICLAEAGWPVRVWAAALPQQTTS
AVAGAVWGPRPKEPVAKVRGWIEQSLHVFRDLAKDPATGVRMTPALSVGDRIETGAMP
PGLELIPDVRPADPADVPGGFRAGFHATLPMIDMPQYLDCLTQRLAATGCEIETRPLR
SLAEAAEAAPIVINCAGLGARELAGDATVWPRFGQHVVLTNPGLEQLFIERTGGSEWI
CYFAHPQRVVCGGISIPGRWDPTPEPEITERILQRCRRIQPRLAEAAVIETITGLRPD
RPSVRVEAEPIGRALCIHNYGHGGDGVTLSWGCAREVVNLVGGG"
gene complement(2152425..2152895)
/locus_tag="Rv1906c"
CDS complement(2152425..2152895)
/codon_start=1
/transl_table=11
/locus_tag="Rv1906c"
/product="Conserved protein"
/note="Rv1906c, (MTCY180.12), len: 156 aa. Conserved
protein, possibly exported protein, equivalent to
Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa), FASTA
scores: opt: 637, E(): 2.6e-28, (63.2% identity in 155 aa
overlap). Also similar to M. tuberculosis hypothetical
exported protein, Rv1352. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004). Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1906c"
/db_xref="EnsemblGenomes-Tr:CCP44673"
/db_xref="GOA:O07726"
/db_xref="UniProtKB/TrEMBL:O07726"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44673.1"
/translation="MRLKPAPSPAAAFAVAGLILAGWAGSVGLAGADPEPAPTPKTAI
DSDGTYAVGIDIAPGTYSSAGPVGDGTCYWKRMGNPDGALIDNALSKKPQVVTIEPTD
KAFKTHGCQPWQNTGSEGAAPAGVPGPEAGAQLQNQLGILNGLLGPTGGRVPQP"
gene complement(2153235..2153882)
/locus_tag="Rv1907c"
CDS complement(2153235..2153882)
/codon_start=1
/transl_table=11
/locus_tag="Rv1907c"
/product="Hypothetical protein"
/note="Rv1907c, (MTCY180.11), len: 215 aa. Hypothetical
unknown protein. Similar to Q50763 Ethyl methane
sulphonate resistance protein from Mycobacterium
tuberculosis (168 aa), FASTA scores: opt: 638, E(): 0,
(69.7% identity in 152 aa overlap). Downstream of a cloned
katG gene (EMBL:mtkatg). Differences are due to frameshift
errors in the EMBL sequence and the use of an earlier
start codon. Alternative nucleotide at position 2153410
(a->G; V158A) has been observed."
/db_xref="EnsemblGenomes-Gn:Rv1907c"
/db_xref="EnsemblGenomes-Tr:CCP44674"
/db_xref="InterPro:IPR025358"
/db_xref="UniProtKB/TrEMBL:L0TAY1"
/protein_id="CCP44674.1"
/translation="MIGPARRSTTTRRSTPRADRLAGCWCLPGAICQTPRAWWSQARR
DGDDETGMRRKGAEMCWMCDHPEATAEEYLDEVYGIMLMHGWAVQHVECERRPFAYTV
GLTRRGLPELVVTGLSPRRGQRLLNIAARRALVGDLLTPGMQTTLPAGPLVETVQVTH
PDAHLYCAIAIFGDKVTALQLVWADRRGRWPWAADFDEGRGTQPVLGMRATRRSA"
gene complement(2153889..2156111)
/gene="katG"
/locus_tag="Rv1908c"
CDS complement(2153889..2156111)
/codon_start=1
/transl_table=11
/gene="katG"
/locus_tag="Rv1908c"
/product="Catalase-peroxidase-peroxynitritase T KatG"
/note="Rv1908c, (MTCY180.10), len: 740 aa.
KatG,catalase-peroxidase-peroxynitritase T (see citations
below), HPI. FASTA results: Q57215 catalase-peroxidase
from Mycobacterium tuberculosis (740 aa) opt: 5081, E():
0,(100% identity in 740 aa overlap). Contains peroxidases
active site signature (PS00436) and ATP/GTP-binding site
motif A (P-loop; PS00017). Cosmid sequence was corrected
to agree with a sequencing read from the H37Rv genome.
Deletions or defects in KATG gene cause isoniazid (INH)
resistance. Belongs to the peroxidase family. Bacterial
peroxidase/catalase subfamily. KATG transcription seems to
be regulated by FURA|Rv1909c product. The
catalase-peroxidase activity is associated with the
amino-terminal domain but no definite function has been
assigned to the carboxy-terminal domain. Predicted
possible vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1908c"
/db_xref="EnsemblGenomes-Tr:CCP44675"
/db_xref="GOA:P9WIE5"
/db_xref="InterPro:IPR000763"
/db_xref="InterPro:IPR002016"
/db_xref="InterPro:IPR010255"
/db_xref="InterPro:IPR019793"
/db_xref="InterPro:IPR019794"
/db_xref="PDB:1SFZ"
/db_xref="PDB:1SJ2"
/db_xref="PDB:2CCA"
/db_xref="PDB:2CCD"
/db_xref="PDB:4C50"
/db_xref="PDB:4C51"
/db_xref="UniProtKB/Swiss-Prot:P9WIE5"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00436"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44675.1"
/translation="MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLN
LKVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLF
IRMAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLS
WADLIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLEN
PLAAVQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTH
GAGPADLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLE
ILYGYEWELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSLRVDPIYER
ITRRWLEHPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHDLV
GEAEIASLKSQIRASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVN
DPDGDLRKVIRTLEEIQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVP
FTPGRTDASQEQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEM
TVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKD
GSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR
"
gene complement(2156149..2156592)
/gene="furA"
/locus_tag="Rv1909c"
CDS complement(2156149..2156592)
/codon_start=1
/transl_table=11
/gene="furA"
/locus_tag="Rv1909c"
/product="Ferric uptake regulation protein FurA (fur)"
/note="Rv1909c, (MTCY180.09), len: 147 aa. FurA, Ferric
uptake regulation protein, similar to Q48835 legionella
pneumophila 130B (wadsworth) ferric uptake regulation (136
aa), FASTA results: opt: 230, E(): 2.5e-09, (32.3%
identity in 133 aa overlap). Also similar to Mycobacterium
tuberculosis zur zinc uptake regulatory protein, Rv2359.
Belongs to the fur family. Start changed since original
submission (-3 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1909c"
/db_xref="EnsemblGenomes-Tr:CCP44676"
/db_xref="GOA:P9WN87"
/db_xref="InterPro:IPR002481"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WN87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44676.1"
/translation="MSSIPDYAEQLRTADLRVTRPRVAVLEAVNAHPHADTETIFGAV
RFALPDVSRQAVYDVLHALTAAGLVRKIQPSGSVARYESRVGDNHHHIVCRSCGVIAD
VDCAVGEAPCLTASDHNGFLLDEAEVIYWGLCPDCSISDTSRSHP"
gene complement(2156706..2157299)
/locus_tag="Rv1910c"
CDS complement(2156706..2157299)
/codon_start=1
/transl_table=11
/locus_tag="Rv1910c"
/product="Probable exported protein"
/note="Rv1910c, (MTCY180.08), len: 197 aa. Possible
exported protein, very similar to upstream ORF MTCY180.07
(201 aa), FASTA score: E(): 0, (64.0% identity in 200 aa
overlap). Also similar to Q9Z729|Y877_CHLPN protein
CPN0877 from Chlamydophila pneumoniae (150 aa). Predicted
to be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1910c"
/db_xref="EnsemblGenomes-Tr:CCP44677"
/db_xref="GOA:P9WFN5"
/db_xref="InterPro:IPR005247"
/db_xref="InterPro:IPR008914"
/db_xref="InterPro:IPR036610"
/db_xref="UniProtKB/Swiss-Prot:P9WFN5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44677.1"
/translation="MAHAFHRFALAILGLALPVALVAYGGNGDSRKAAPLAPKAAALG
RSMPETPTGDVLTISSPAFADGAPIPEQYTCKGANIAPPLTWSAPFGGALVVDDPDAP
REPYVHWIVIGIAPGAGSTADGETPGGGISLPNSSGQPAYTGPCPPAGTGTHHYRFTL
YHLPAVPPLAGLAGTQAARVIAQAATMQARLIGTYEG"
gene complement(2157382..2157987)
/gene="lppC"
/locus_tag="Rv1911c"
CDS complement(2157382..2157987)
/codon_start=1
/transl_table=11
/gene="lppC"
/locus_tag="Rv1911c"
/product="Probable lipoprotein LppC"
/note="Rv1911c, (MTCY180.07), len: 201 aa. Probable
lipoprotein lppC, contains appropriately positioned
prokaryotic membrane lipoprotein lipid attachment site
(PS00013). Very similar to downstream ORF MTCY180.08 (204
aa) (although this lacks lipoprotein motif), FASTA score:
opt: 831, E(): 0, (64.0% identity in 200 aa overlap). Also
similar to Q9Z729|Y877_CHLPN hypothetical protein CPN0877
from Chlamydia pneumoniae (strain CWL029) (150 aa)."
/db_xref="EnsemblGenomes-Gn:Rv1911c"
/db_xref="EnsemblGenomes-Tr:CCP44678"
/db_xref="GOA:P9WFN3"
/db_xref="InterPro:IPR005247"
/db_xref="InterPro:IPR008914"
/db_xref="InterPro:IPR036610"
/db_xref="UniProtKB/Swiss-Prot:P9WFN3"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44678.1"
/translation="MTSTLHRTPLATAGLALVVALGGCGGGGGDSRETPPYVPKATTV
DATTPAPAAEPLTIASPMFADGAPIPVQFSCKGANVAPPLTWSSPAGAAELALVVDDP
DAVGGLYVHWIVTGIAPGSGSTADGQTPAGGHSVPNSGGRQGYFGPCPPAGTGTHHYR
FTLYHLPVALQLPPGATGVQAAQAIAQAASGQARLVGTFEG"
gene complement(2158087..2159091)
/gene="fadB5"
/locus_tag="Rv1912c"
CDS complement(2158087..2159091)
/codon_start=1
/transl_table=11
/gene="fadB5"
/locus_tag="Rv1912c"
/product="Possible oxidoreductase FadB5"
/note="Rv1912c, (MTCY180.06), len: 334 aa. Possible
fadB5,oxidoreductase, similar to various oxidoreductases:
3-hydroxyacyl-CoA dehydrogenase, quinone
oxidoreductases,and polyketide synthases, e.g.
NP_104067.1|NC_002678 probable oxidoreductase from
Mesorhizobium loti (308 aa); NP_464140.1|NC_003210 protein
similar to oxidoreductase from Listeria monocytogenes (313
aa); NP_193889.1|NC_003075 putative NADPH quinone
oxidoreductase from Arabidopsis thaliana (325 aa);
NP_001880.2|NM_001889 crystallin, zeta; quinone
oxidoreductase; NADPH:quinone reductase from Homo sapiens
(329 aa); part 2983 to 3197 of T17410 polyketide synthase
type I from Streptomyces venezuelae (3739 aa);
Q53927|SCBAC20F6.16 hydroxyacyl-CoA dehydrogenase from
Streptomyces coelicolor (329 aa), FASTA scores: opt:
621,E(): 2e-30, (39.5% identity in 349 aa overlap); etc.
Also similar to many hypothetical Mycobacterium
tuberculosis proteins including: MTCY24G1.09,
MTCY13D12.11, MTCY19H9.01,MTCY24G1.03, MTCY03A2.17c, etc.
Contains quinone oxidoreductase/zeta-crystallin signature
(PS01162)."
/db_xref="EnsemblGenomes-Gn:Rv1912c"
/db_xref="EnsemblGenomes-Tr:CCP44679"
/db_xref="GOA:O07721"
/db_xref="InterPro:IPR002364"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O07721"
/inference="protein motif:PROSITE:PS01162"
/protein_id="CCP44679.1"
/translation="MRAVVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFAD
HLARVGLYPDAPKLPAVVGYEVAGTVEAVGDGVDPNRVGERVLAGTRFGGYCEIVNVA
ATDSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLRAGERVLIHAAAGGVGIAAVQF
AKAAKAEVHGTASPQKHQKLAEFGVDRAIDYRRDGWWQGLGPYDVVLDALGGTSLRRS
YTLLRPGGRLVGYGISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNML
RLWDDRRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAPEAHRILAARENVDKVVLVP
"
gene 2159191..2159943
/locus_tag="Rv1913"
CDS 2159191..2159943
/codon_start=1
/transl_table=11
/locus_tag="Rv1913"
/product="Conserved hypothetical protein"
/note="Rv1913, (MTCY180.05c), len: 250 aa. Conserved
hypothetical protein, slight similarity to dehydrase and
beta-lactamase precursors e.g. Q02057 dehydrase from
Streptomyces coelicolor (297 aa), FASTA scores: opt:
184,E(): 4.3e-05, (31.6% identity in 215 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1913"
/db_xref="EnsemblGenomes-Tr:CCP44680"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:O07720"
/protein_id="CCP44680.1"
/translation="MHFDWERLTDSVHRCRLPFCDVTVGLVRGRTGILLVDTGTTLGE
ATAIAADVKQIAGCQVTHVVLTHKHFDHVLGSSVFDQAEVFCAPEVVEYLRSATDRLR
EDALSYGADTAEVDRAIAALKPPQHGIYDAAVDLGDRTVTITHPGSGHTTADLVVVAP
ATGHADGPTVVFTGDLVEESADPDIDADSDLAAWPATLDRVLAIGGPDASYVPGHGKV
VDAQFVRRQRAWLRTRASRQPRETPATLPCKR"
gene complement(2159921..2160328)
/locus_tag="Rv1914c"
CDS complement(2159921..2160328)
/codon_start=1
/transl_table=11
/locus_tag="Rv1914c"
/product="Unknown protein"
/note="Rv1914c, (MTCY180.04), len: 135 aa. Unknown
protein. Predicted to be an outer membrane protein (See
Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1914c"
/db_xref="EnsemblGenomes-Tr:CCP44681"
/db_xref="GOA:O07719"
/db_xref="UniProtKB/TrEMBL:O07719"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44681.1"
/translation="MVLSRTSTGRVILVPTQLRFDRWFLPLAVPLGLGPKNSELWVGA
GSLHVKMGWAFAADIPLTSITKAEATNARVYAAGVHFGFGRWLVNGSRKGLVALTIDP
PEQAKMWKKSMTVRELWVSVTDPDALVTACTAK"
gene 2160463..2161566
/gene="aceAa"
/gene_synonym="icl2a"
/locus_tag="Rv1915"
CDS 2160463..2161566
/codon_start=1
/transl_table=11
/gene="aceAa"
/gene_synonym="icl2a"
/locus_tag="Rv1915"
/product="Probable isocitrate lyase AceAa [first part]
(isocitrase) (isocitratase) (Icl)"
/note="Rv1915, (MTCY180.03c), len: 367 aa. Probable
aceAa,isocitrate lyase (see citations below). Highly
similar to the N-terminus of ACEA_MYCLE isocitrate lyase
from Mycobacterium leprae (606 aa), FASTA results: opt:
3314,E(): 0, (86.5% identity in 572 aa overlap). Contains
PS00161 Isocitrate lyase signature. Although this ORF and
the downstream ORF representing the C-terminal half of
aceA could be joined by a frameshift, no error is apparent
in the cosmid, or in a seqencing read from the genome of
H37Rv. As the downstream ORF has a RBS and transcriptional
start immediately following the stop of this ORF, it is
possible that they are expressed as two separate modules.
In Mycobacterium tuberculosis strain CDC1551, aceA exists
as a single gene, MT1966: the corresponding protein has
been purified experimentally and seems have an active
isocitrate lyase activity (see Honer et al., 1999). For
Mycobacterium tuberculosis strain H37Rv, immunoblot assay
didn't detect AceAa or AceAb products (see Honer et
al.,1999) but mRNA of AceAa|Rv1915 has been detected (see
Betts et al., 2002); so AceAb|Rv1916 could be a
pseudogene. Icl2 has 2-methyl-isocitrate lyase (MCL)
activity in M. tuberculosis Erdman (See Munoz-Elias et
al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv1915"
/db_xref="EnsemblGenomes-Tr:CCP44682"
/db_xref="GOA:O07718"
/db_xref="InterPro:IPR006254"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR018523"
/db_xref="InterPro:IPR039556"
/db_xref="InterPro:IPR040442"
/db_xref="UniProtKB/Swiss-Prot:O07718"
/inference="protein motif:PROSITE:PS00161"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44682.1"
/translation="MAIAETDTEVHTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTAR
QVVEQRGTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEA
IYLGGWATSAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSER
QRAATPAYDFRPFIIADAGTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQ
GGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADERDQPFLLGA
TKLDVPSYKSCFLAMVRRFTNWASRSSMVIFSMRLATASTRRPAVGLSAKAFSAWSPT
RSTRGGRTASSRSTAFSTRSSRGSWRPGRTTRA"
gene 2161566..2162762
/gene="aceAb"
/gene_synonym="icl2b"
/locus_tag="Rv1916"
CDS 2161566..2162762
/codon_start=1
/transl_table=11
/gene="aceAb"
/gene_synonym="icl2b"
/locus_tag="Rv1916"
/product="Probable isocitrate lyase AceAb [second part]
(isocitrase) (isocitratase) (Icl)"
/note="Rv1916, (MTCY180.02c), len: 398 aa. Probable
aceAb,isocitrate lyase (see citations below). Highly
similar to the C-terminus of ACEA_MYCLE|P46831 isocitrate
lyase from Mycobacterium leprae (606 aa), FASTA results:
opt: 1635,E(): 0, (86.3% identity in 278 aa overlap).
Although this ORF and the upstream ORF representing the
N-terminal half of aceA could be joined by a frameshift no
error is apparent in the cosmid, or in a seqencing read
from the genome of H37Rv. As this ORF has a RBS and
transcriptional start immediately following the stop of
the upstream ORF,it is possible that they are expressed as
two separate modules. In Mycobacterium tuberculosis strain
CDC1551, aceA exists as a single gene, MT1966: the
corresponding protein has been purified experimentally and
seems have an active isocitrate lyase activity (see Honer
et al., 1999). For Mycobacterium tuberculosis strain
H37Rv, immunoblot assay didn't detect AceAa or AceAb
products (see Honer et al.,1999) but mRNA of AceAa|Rv1915
has been detected (see Betts et al., 2002); so
AceAb|Rv1916 could be a pseudogene. Icl2 has
2-methyl-isocitrate lyase (MCL) activity in M.
tuberculosis Erdman (See Munoz-Elias et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv1916"
/db_xref="EnsemblGenomes-Tr:CCP44683"
/db_xref="GOA:O07717"
/db_xref="InterPro:IPR006254"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR040442"
/db_xref="UniProtKB/Swiss-Prot:O07717"
/protein_id="CCP44683.1"
/translation="MTYGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARAKA
KELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQ
FAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQI
DGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTA
TTKAMGKGSTQHQHLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVLEL
GIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKA
QAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRK
LITKEA"
gene complement(2162932..2167311)
/gene="PPE34"
/locus_tag="Rv1917c"
CDS complement(2162932..2167311)
/codon_start=1
/transl_table=11
/gene="PPE34"
/locus_tag="Rv1917c"
/product="PPE family protein PPE34"
/note="Rv1917c, (MTV050.01c-MTCY180.01), len: 1459 aa.
PPE34, Member of the Mycobacterium tuberculosis PPE family
of glycine-rich proteins, MPTR subfamily (see citation
below). Similar to MTCY28.16, MTCY13E10.17,
MTCY63.10,MTV004.05, MTCY98.24, MTCY6G11.05, etc.
C-terminus is identical to Q50471. Unknown Mycobacterium
tuberculosis protein (693 aa), FASTA results: opt: 2635,
E(): 0, (99.7% identity in 391 aa overlap). Start changed
since original submission (+23 aa). Thougth to be surface
exposed,cell-wall associated."
/db_xref="EnsemblGenomes-Gn:Rv1917c"
/db_xref="EnsemblGenomes-Tr:CCP44684"
/db_xref="GOA:Q79FI9"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:Q79FI9"
/inference="protein motif:PROSITE:PS00879"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44684.1"
/translation="MNFSTLPPEINSALIFGGAGSEPMSAAAVAWDQLAMELASAAAS
FNSVTSGLVGESWLGPSSAAMAAAVAPYLGWLAAAAAQAQRSATQAAALVAEFEAVRA
AMVQPALVAANRSDLVSLVFSNFFGQNAPAIAAIEAAYEQMWAIDVSVMSAYHAGASA
VASALTPFTAPPQNLTDLPAQLAAAPAAVVTAAITSSKGVLANLSLGLANSGFGQMGA
ANLGILNLGSLNPGGNNFGLGNVGSNNVGLGNTGNGNIGFGNTGNGNIGFGLTGDNQQ
GFGGWNSGTGNIGLFNSGTGNIGIGNTGTGNFGIGNSGTSYNTGIGNTGQANTGFFNA
GIANTGIGNTGNYNTGSFNLGSFNTGDFNTGSSNTGFFNPGNLNTGVGNTGNVNTGGF
NSGNYSNGFFWRGDYQGLIGFSGTLTIPAAGLDLNGLGSVGPITIPSITIPEIGLGIN
SSGALVGPINVPPITVPAIGLGINSTGALVGPINIPPITLNSIGLELSAFQVINVGSI
SIPASPLAIGLFGVNPTVGSIGPGSISIQLGTPEIPAIPPFFPGFPPDYVTVSGQIGP
ITFLSGGYSLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGGLGPFTVFPDGY
SLPAIPLGIDVGGGLGPFTVFPDGYSLPAIPLGIDVGGAIGPLTTPPITIPSIPLGID
VSGSLGPINIPIEIAGTPGFGNSTTTPSSGFFNSGTGGTSGFGNVGSGGSGFWNIAGN
LGNSGFLNVGPLTSGILNFGNTVSGLYNTSTLGLATSAFHSGVGNTDSQLAGFMRNAA
GGTLFNFGFANDGTLNLGNANLGDYNVGSGNVGSYNFGSGNIGNGSFGFGNIGSNNFG
FGNVGSNNLGFANTGPGLTEALHNIGFGNIGGNNYGFANIGNGNIGFGNTGTGNIGIG
LTGDNQVGFGALNSGSGNIGFFNSGNGNIGFFNSGNGNVGIGNSGNYNTGLGNVGNAN
TGLFNTGNVNTGIGNAGSYNTGSYNAGDTNTGDLNPGNANTGYLNLGDLNTGWGNIGD
LNTGALISGSYSNGILWRGDYQGLIGYSDTLSIPAIPLSVEVNGGIGPIVVPDITIPG
IPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVG
PIVVPDITIPGIPLSLNALGGVGPIVVPDITIPGIPLSLNALGGVGPITVPGVPISRI
PLTINIRIPVNITLNELPFNVAGIFTGYIGPIPLSTFVLGVTLAGGTLESGIQGFSVN
PFGLNIPLSGATNAVTIPGFAINPFGLNVPLSGGTSPVTIPGFAINPFGLNVPLSGGT
SPVTIPGFTIPGSPLNLTANGGLGPINIPINITSAPGFGNSTTTPSSGFFNSGDGSAS
GFGNVGPGISGLWNQVPNALQGGVSGIYNVGQLASGVANLGNTVSGFNNTSTVGHLTA
AFNSGVNNIGQMLLGFFSPGAGP"
repeat_region complement(2163323..2163392)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 3,
TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCC
CGGCTTCACCAT"
repeat_region complement(2163393..2163461)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 2,
TTAATCCGTTTGGGTTGAATGTTCCGTTGAGCGGGGGCACGAGCCCGGTTACGATCCC
TGGTTTCGCGA"
repeat_region complement(2163462..2163530)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 1,
TTAATCCGTTCGGTTTGAATATTCCGCTGAGCGGTGCTACCAACGCTGTCACGATCCC
TGGTTTCGCGA"
repeat_region complement(2163741..2163809)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 5,
TCGGTCCGATTGTGGTGCCTGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC
GCTGGGTGGTG"
repeat_region complement(2163810..2163878)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 4,
TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC
GCTGGGTGGTG"
repeat_region complement(2163879..2163947)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 3,
TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC
GCTGGGTGGTG"
repeat_region complement(2163948..2164016)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 2,
TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC
GCTGGGTGGTG"
repeat_region complement(2164017..2164085)
/gene="PPE34"
/locus_tag="Rv1917c"
/note="69 bp imperfect direct repeat 1,
TCGGTCCGATTGTGGTGCCGGATATTACTATTCCTGGTATTCCGTTGAGCCTGAACGC
GCTGGGTGGTG"
gene complement(2167649..2170612)
/gene="PPE35"
/locus_tag="Rv1918c"
CDS complement(2167649..2170612)
/codon_start=1
/transl_table=11
/gene="PPE35"
/locus_tag="Rv1918c"
/product="PPE family protein PPE35"
/note="Rv1918c, (MTV050.02c), len: 987 aa. PPE35, Member
of the Mycobacterium tuberculosis PPE family of
glycine-rich proteins. Similar to MTCY28.16|Z95890
Mycobacterium tuberculosis cosmid (1053 aa), FASTA scores:
opt: 3404,E(): 0, (65.6% identity in 1058 aa overlap).
Also similar to MTV004.05, MTY13E10.17, MTV014.03,
MTCY3C7.23,MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07,
MTCY4C12.36,MTCY180.01, etc."
/db_xref="EnsemblGenomes-Gn:Rv1918c"
/db_xref="EnsemblGenomes-Tr:CCP44685"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q79FI8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44685.1"
/translation="MHYSVLPPEINSALIFAGAGSGPMLAAASAWDGLATELASAAVS
FGSVTAGLVGGSWQGRSSVAMAAAAAPYAGWLAAAATQAEQAATQAQVMVAEFEAVRL
AMVQPALVAANRSGLISLVISNLFGQNAPAIAAAEAAYEEMWALDVSAMAAYHSGASA
VAVALPAFALPLRLPAGLAAGPAAVVTALTTAVGMPTFAGRAIAASLGLANVGGGNLG
NANNGLGNIGNANLGNNNLGSGNFGSFNIGSANLGGNNIGIGNAGANNFGLANLGNLN
TGFANAGIGNFGIANTGNNNIGNGLTGNNQIGIGGLNSGNGNVGLFNAGSANIGFFNS
GNGNFGIGNSGNFSTGLFNPGHGNTGFLNAGSFNTGMFDVGNANTGSFNVGHYNFGAF
NPGPSNTGTFNTGGANTGWFNTGSINTGAFNIGDMNNGLFNTGDMNNGVFYRGVGQGS
LQFAITSPDLTLPSLEIPGISVPAFSLPAITLPSLTIPAVTTPANVTVGAFDLPGLTV
PSLTIPAAMTPANITVGAFDLPGLTVPSLTIPATTTPANITVGAFNLPQLSIPSVTVP
PITIPAGTALGAFNLPTLSIPSVTVPPITIPAGTTVGGFTLPTIHTPLISTPQISIGG
FSTPGIATQANSGVINLPTFSLNGITITNLVVFIPNNITALQTNMPGVFPQIGGFANT
PPAFINTGTITVGGGQINGVGFSIGAINVTPFTLPNVVIQPWSLGGISVDGFTLPEIS
TQEFTTPALTISPIGVGALSLPDITTQQFTTPELTIDPITLGGFTLPQLSIPAITTPA
FTIDPIALGGFTLPQIMTPEITTPPFAIDPIGLSGFTLPQVNIPEITTPEFTIQPVGL
AAFTTPALTIASIHLPSTTMGGFAIPAGPGYFNSSATPSLGFFNAGIGGNSGFGNSGS
GLSGWFNTSPVGLLAGSGYQNYGGLISGFSNLGSGISGFANTGTLPFAVTSLVSGLAN
IGNNLSGLFFQSTTP"
gene complement(2171061..2171525)
/locus_tag="Rv1919c"
CDS complement(2171061..2171525)
/codon_start=1
/transl_table=11
/locus_tag="Rv1919c"
/product="Conserved protein"
/note="Rv1919c, (MTV050.03c), len: 154 aa. Conserved
protein, shows weak similarity to several major pollen
antigens e.g. Z72431|BVGC25_1 major allergen bet V 1 from
Betula verrucosa (160 aa), FASTA scores: opt: 133, E():
0.012, (26.8% identity in 149 aa overlap). Also shows some
similarity to Rv2574|MTCY227.27C Hypothetical protein from
Mycobacterium tuberculosis (167 aa), (27.4% identity in
124 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1919c"
/db_xref="EnsemblGenomes-Tr:CCP44686"
/db_xref="GOA:O53961"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O53961"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44686.1"
/translation="MSGRKFSFEVTKTSSAPAATLFRLVTDGGNWATWAKPIVAQSSW
ARRGDPAPGGIGAIRKLGMWPVFVQEETVEYEQDRRHVYKLVGARTPVQDYFGEVVLT
PNASGGTDLRWSGSFTEKVRGTGPVMRAALGGAVRFFAGQLVKAAEREAVRR"
gene 2171623..2172486
/locus_tag="Rv1920"
CDS 2171623..2172486
/codon_start=1
/transl_table=11
/locus_tag="Rv1920"
/product="Probable membrane protein"
/note="Rv1920, (MTV050.04), len: 287 aa. Probable membrane
protein, similar to AL0215|SC10A5.04 putative membrane
protein from Streptomyces coelicolor cosmid 10A5 (295
aa),FASTA scores: opt: 292, E(): 3.6e-13, (31.3% identity
in 243 aa overlap). Also weakly similar to several
Mycobacterial putative proteins with unknown function e.g.
Rv0502, Rv1428c, U00018_22 Mycobacterium leprae cosmid
B2168."
/db_xref="EnsemblGenomes-Gn:Rv1920"
/db_xref="EnsemblGenomes-Tr:CCP44687"
/db_xref="GOA:O53962"
/db_xref="InterPro:IPR002123"
/db_xref="InterPro:IPR016676"
/db_xref="UniProtKB/TrEMBL:O53962"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44687.1"
/translation="MFPRWPQQAHNHEVSRADTVSVPRAPTQAEVAAVLRIMTPLRKV
IKPKVYGIENVPTERALLVGNHNTLGLVDAPLLAAELWERGRIVRSLGDHAHFKIPGW
RDALTRTGVVEGTREITSELMRRGELVMVFPGGAREVNKRKNERYKLVWKNRLGFARL
AIQHGYPIVPFASVGAEHGIDIVLDNESPLLAPVQFLAEKLLGTKDGPALVRGVGLTP
VPRPERQYYWFGEPIDTTEFMGQQADDNAARRVRERAAAAIEHGIELMLAERAADPNR
SLVGRLLRSDA"
gene complement(2172524..2173795)
/gene="lppF"
/locus_tag="Rv1921c"
CDS complement(2172524..2173795)
/codon_start=1
/transl_table=11
/gene="lppF"
/locus_tag="Rv1921c"
/product="Probable conserved lipoprotein LppF"
/note="Rv1921c, (MTCY09F9.43-MTV050.05c), len: 423 aa.
Probable lppF, conserved lipoprotein, similar to G403173
lipoprotein precursor (fragment) from Rhodococcus
erythropolis (225 aa), fasta scores: opt: 364, E():
9.2e-19, (41.9% identity in 148 aa overlap). Contains
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site."
/db_xref="EnsemblGenomes-Gn:Rv1921c"
/db_xref="EnsemblGenomes-Tr:CCP44688"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/TrEMBL:O53963"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP44688.1"
/translation="MVRLIPSLLAMATVLGGVIGCSAHQPPTPASGCRQLDAFLKWHH
GVREFLQSAIDANSRCTGTADGSARKVAIFDWDNTVVKNDIGYATNYYMLQHSLVLQP
ANQDWHAASRYLTDAAANALSVACGKVVPAGKPLPTGSNALCANEILSLLDGETTTGQ
PAFVGNNVRRLAGPYAWSNALSAGYTAEELAGFADQAKKQNLAADVGATQQVGTQQVD
GYIRVYPQMKDLIGTLQAHGIDTWVVSASPEPIVKVWAGEVGLDDQHVVGVRSVADQS
GKLTAHLVGCGGVRDGDDSVMTYLDGKRCWANQVIFGVTGPQAFNQLAADRRQVLAAG
DSNSDATFVGDATVVSLVINRNQDDLMCRAYDGLFTRGGKWAINPMFIDPLPQHAPYV
CGEAFINPDGSKQPVLRNDGTPIPDQVDSVF"
gene 2174067..2175182
/locus_tag="Rv1922"
CDS 2174067..2175182
/codon_start=1
/transl_table=11
/locus_tag="Rv1922"
/product="Probable conserved lipoprotein"
/note="Rv1922, (MTCY09F9.42c), len: 371 aa. Probable
conserved lipoprotein, possibly peptidase similar to many
peptidases, e.g. P15555|DAC_STRSQ D-alanyl-D-alanine
carboxypeptidase from Streptomyces sp. (406 aa), FASTA
scores: opt: 382, E(): 3.1e-17, (28.0% identity in 379 aa
overlap). Also similar to Mycobacterium tuberculosis
hypothetical proteins Rv1497, Rv2463, Rv3775, etc.
Contains PS00013 Prokaryotic membrane lipoprotein lipid
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv1922"
/db_xref="EnsemblGenomes-Tr:CCP44689"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:P95291"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44689.1"
/translation="MDSTVTASIRRMLGLLAATLLLGGCTGQHTTRTAASTTYTPHIK
ASSQDVLDGAINADEPGCSAAVGVEGKVIWSGVRGIADLASGAKITTDTVFDIASVSK
QFTATAILLLVEAGKLTLDDPISQYVPELPDWAQTVTVEQLMHQTSGIPDYVALLAAR
GYQVSDRTIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLGEIVHRASGQPLPEFLS
AEIFQPLGLAMVVDPVGKVPNKAVSYEKGTGGNRSEYRVGNPAWEQIGDGGIQTTPSQ
LARWADNYRTGSVGGLKLLEAQLAGAVETEPGGGDRYGAGIVSRADGTLDHAGAWAGF
VTAFHISSDRRTSVAISCNTDKPDPVAMADALGRLWM"
gene 2175173..2176513
/gene="lipD"
/locus_tag="Rv1923"
CDS 2175173..2176513
/codon_start=1
/transl_table=11
/gene="lipD"
/locus_tag="Rv1923"
/product="Probable lipase LipD"
/note="Rv1923, (MTCY09F9.41c), len: 446 aa. Probable
lipD,hydrolase lipase, similar to esterases and
beta-lactamases e.g. G151214 esterase, (389 aa), fasta
scores: opt: 569,E(): 5.4e-29, (33.7% identity in 401 aa
overlap). Also similar to Mycobacterium tuberculosis
hypothetical proteins Rv1497, Rv2463, Rv3775, etc."
/db_xref="EnsemblGenomes-Gn:Rv1923"
/db_xref="EnsemblGenomes-Tr:CCP44690"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:P95290"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44690.1"
/translation="MDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDS
RFTGVIRAFAGLYPGRKFGGGALSVYIDGRQVVDVWTGWSDRQGKVPWTADTGAMVFS
ATKGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGKSEVTVSDVLRHRSGLAHLKGV
DKDEVMDHLLMEQKLAAAPLDRQHGKLAYHAVTYGWLLSGLARAVTGKGMRELFREEL
ARPLNTDGIHLGRPPADSPTKAAQTLLPQAKVPTPLLDFIAPKVAGLSFSGLLGAVYF
PGILSLLQDDMPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLSSQAVRGLT
GKSELWPDLNLGLPFTYHQGYQSSPVPGLLEGYGHIGLGGTIGWADPETGSAFGYVHN
RLLTLLLFDIGSFAGLAALLNSAVVAARRDDPLEVPHFGAPYSEPRHEQAASGA"
gene complement(2176550..2176930)
/locus_tag="Rv1924c"
CDS complement(2176550..2176930)
/codon_start=1
/transl_table=11
/locus_tag="Rv1924c"
/product="Unknown protein"
/note="Rv1924c, (MTCY09F9.40), len: 126 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1924c"
/db_xref="EnsemblGenomes-Tr:CCP44691"
/db_xref="GOA:P95289"
/db_xref="UniProtKB/TrEMBL:P95289"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44691.1"
/translation="MDPADVINPTSTRDAALARVLAYRQRVRARPLLIRATLAVVGGG
LFVVSLPMIVLLPELGIPALLVAFRLLAVEAQWAVRAYAWTDWRFTQLREWFHRQVLV
TRAAILVGLFLAAVALVWLLVYEF"
gene 2177087..2178949
/gene="fadD31"
/locus_tag="Rv1925"
CDS 2177087..2178949
/codon_start=1
/transl_table=11
/gene="fadD31"
/locus_tag="Rv1925"
/product="Probable acyl-CoA ligase FadD31 (acyl-CoA
synthetase) (acyl-CoA synthase)"
/note="Rv1925, (MTCY09F9.39c), len: 620 aa. Probable
fadD31, acyl-CoA synthetase, highly similar to others from
Mycobacterium leprae e.g. NP_301198.1|NC_002677 putative
acyl-CoA synthetase (635 aa); NP_302537.1|NC_002677
probable acyl-CoA synthase (583 aa); etc. Also highly
similar to others from Mycobacterium tuberculosis e.g.
fadD32 (637 aa); fadD21 (578 aa); fadD29 (619 aa);
fadD26|FD26_MYCTU|Q10976 (626 aa), FASTA scores: opt:
945,E(): 0, (39.8% identity in 598 aa overlap); etc. Also
similar to N-terminus of G1171128 saframycin MX1
synthetase B from Myxococcus xanthus (1770 aa), FASTA
scores: opt: 845, E(): 0, (37.4% identity in 593 aa
overlap); N-terminus of T34918 polyketide synthase from
Streptomyces coelicolor (2297 aa); etc. Nucleotide
position 2177654 in the genome sequence has been
corrected, A:C resulting in M190L."
/db_xref="EnsemblGenomes-Gn:Rv1925"
/db_xref="EnsemblGenomes-Tr:CCP44692"
/db_xref="GOA:I6Y7V6"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:I6Y7V6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44692.1"
/translation="MNDGSRQELRVRSGLLQIEDCLDADGGIALPAGTTLISLIERNI
KYVGDLVAYRYLDHARSAAGCALEVTWTQFGMRLAAIGAHVQRFAGPGDRVAILAPQG
IDYVCGFYAAIKAGTVAVPLFAPELPGHAERLDTALRDSEPAVILTTAAAKNAVEGFL
NNVPRLRKPTVLVIDQIPDREGELFVPVELDIDAVSHLQYTSGSTRPPVGVEITHRAV
GTNLVQMILSIDLLNRNTHGVSWLPLYHDMGLSMIGFPAVYGGHSTLMSPTAFVRRPL
RWIQALSEGSRTGRVVTAAPNFAYEWAAQRGLPAQGDDVDLSNVVLIIGSEPVSIDAV
TTFNKAFAPYGLPRTAFKPSYGIAEATLLVATIDHAAEPTVVYLDPEQLGAGHATRVA
PDAPNAVVHVSCGHVARSLWAVIVDPDTGPEAGAELPDGEIGEVWLQGDNVARGYWGR
PEETRMTFGARLQSPLAEGSHADGSAIDDTWLRTGDLGVYLDGELYITGRIADLLTID
GRNHYPQDIEATAAEASPMVRRGYITAFTVPASDGDDRNQRLVIIAERAAGTSRSDPR
PALDAIRAAVCNRHGLSVADLSFLPAGAIPRTTSGKLARQACRAQYLSGRLGVH"
gene complement(2178957..2179436)
/gene="mpt63"
/gene_synonym="mpb63"
/locus_tag="Rv1926c"
CDS complement(2178957..2179436)
/codon_start=1
/transl_table=11
/gene="mpt63"
/gene_synonym="mpb63"
/locus_tag="Rv1926c"
/product="Immunogenic protein Mpt63 (antigen Mpt63/MPB63)
(16 kDa immunoprotective extracellular protein)"
/note="Rv1926c, (MT1977, MTCY09F9.38), len: 159 aa. Mpt63
(alternate gene name: mpb63), immunogenic protein (see
citations below), identical to MPT63|MPB63 from
Mycobacterium bovis (159 aa). Exported protein containing
a N-terminal signal sequence: see notes below about
proteomics. Predicted possible vaccine candidate (See Zvi
et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1926c"
/db_xref="EnsemblGenomes-Tr:CCP44693"
/db_xref="GOA:P9WIP1"
/db_xref="InterPro:IPR015250"
/db_xref="InterPro:IPR029050"
/db_xref="PDB:1LMI"
/db_xref="UniProtKB/Swiss-Prot:P9WIP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44693.1"
/translation="MKLTTMIKTAVAVVAMAAIATFAAPVALAAYPITGKLGSELTMT
DTVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEATATVNAIRGSVTPAVSQFNARTAD
GINYRVLWQAAGPDTISGATIPQGEQSTGKIYFDVTGPSPTIVAMNNGMEDLLIWEP"
gene 2179673..2180446
/locus_tag="Rv1927"
CDS 2179673..2180446
/codon_start=1
/transl_table=11
/locus_tag="Rv1927"
/product="Conserved hypothetical protein"
/note="Rv1927, (MTCY09F9.37c), len: 257 aa. Conserved
hypothetical protein, similar to SCG11A.10c|AL133210
hypothetical protein from Streptomyces coelicolor (252
aa),FASTA scores: opt: 729, E(): 0, (48.3% identity in 238
aa overlap). Slight similarity with P54543|YQJF_BACSU
hypothetical 23.9 kDa protein from Bacillus subtilis (209
aa), FASTA scores, opt: 230, E(): 2.8e-08, (28.0% identity
in 164 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1927"
/db_xref="EnsemblGenomes-Tr:CCP44694"
/db_xref="InterPro:IPR018644"
/db_xref="UniProtKB/TrEMBL:P95287"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44694.1"
/translation="MTAIPGPSGAEPGESRALAGYPVTPPALPRPVIFDQRWTDLTFI
HWPVLPESVAGSYPPGTRPDVFADGMTYVGLVPFRMSSTKLGTALPIPYVGTFPETNV
RLYSIDNAGRHGVLFRSLETARLTVVPLTRIGLGIPYAWSRMRMMRSGKHITYHSVRR
WPRRGLRSLLTITIGDLVEPTPLEVWLTARWGAHTRKAGRTWWVPNEHKPWPLRAAEI
AELNDELIDASGVQPTGDRLRALFSPGVHARFGRPCVVQ"
gene complement(2180450..2181217)
/locus_tag="Rv1928c"
CDS complement(2180450..2181217)
/codon_start=1
/transl_table=11
/locus_tag="Rv1928c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv1928c, (MTCY09F9.36), len: 255 aa. Probable
short-chain dehydrogenase/reductase, highly similar to
others e.g. NP_228109.1|NC_000853 oxidoreductase (short
chain dehydrogenase/reductase family) from Thermotoga
maritima (257 aa); T41116 short chain dehydrogenase from
Schizosaccharomyces pombe (261 aa); P87219|SOU1_CANAL
sorbitol utilization protein (SDR family) from Candida
albicans (281 aa); P25529|HDHA_ECOLI
7-alpha-hydroxysteroid dehydrogenase from Escherichia coli
(255 aa), FASTA scores: opt: 541, E(): 1.2e-27, (37.5%
identity in 251 aa overlap); etc. Also similar to many
mycobacterial tuberculosis proteins e.g. Rv1350, Rv0927c,
Rv2002, Rv0769, Rv2766c,etc. Contains PS00061 Short-chain
alcohol dehydrogenase family signature. Belongs to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1928c"
/db_xref="EnsemblGenomes-Tr:CCP44695"
/db_xref="GOA:P95286"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P95286"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44695.1"
/translation="MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAIAARH
LDALEKLADEIGTSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGIDIAVCNAGIITVT
PMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVKQGQGGVIINTASMSGHIINVPQQV
SHYCASKAAVIHLTKAMAVELAPHKIRVNSVSPGYILTELVEPYTEYQPLWEPKIPLG
RLGRPEELAGLYLYLASEASSYMTGSDIVIDGGYTCP"
gene complement(2181262..2181906)
/locus_tag="Rv1929c"
CDS complement(2181262..2181906)
/codon_start=1
/transl_table=11
/locus_tag="Rv1929c"
/product="Conserved hypothetical protein"
/note="Rv1929c, MTCY09F9.35, len: 214 aa. Conserved
hypothetical protein, similar to SC4G6.14|AL096884
hypothetical protein from Streptomyces coelicolor (211
aa),FASTA scores: opt: 416, E(): 2.4e-22, (39.8% identity
in 206 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1929c"
/db_xref="EnsemblGenomes-Tr:CCP44696"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR017519"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/TrEMBL:P95285"
/protein_id="CCP44696.1"
/translation="MADVPLDAQERLELCDLLEELGPAVATLIEGWTAHDLAAHIVLR
ERDLVAGLCIVLPGPFQRFAERRRARLAQSKDFTWLVARIRSGPPMGFFRIGWVRTLA
NLNEFFVHHEDVRRASGRGPRSLTPEMDAALWRNVRRGSHFLSRRLHGCGLEIEWVGT
GKRVRVRSGEPTARLTGPPGELLLYVFGRRAVARVEVSGPLEAIAAVHRTHFGM"
gene complement(2181918..2182442)
/locus_tag="Rv1930c"
CDS complement(2181918..2182442)
/codon_start=1
/transl_table=11
/locus_tag="Rv1930c"
/product="Conserved hypothetical protein"
/note="Rv1930c, MTCY09F9.34, len: 174 aa. Conserved
hypothetical protein, similar to SC5F2A.30|AL049587
hypothetical protein from Streptomyces coelicolor (211
aa),FASTA scores: opt: 307, E(): 2.8e-13, (54.8% identity
in 84 aa overlap). Some similarity to M. tuber culosis
hypothetical protein Rv0052|MTCY21D4.15 (43% identity in
93 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1930c"
/db_xref="EnsemblGenomes-Tr:CCP44697"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/TrEMBL:P95284"
/protein_id="CCP44697.1"
/translation="MTQIAFVAYPGVTALDVVGPYEVLRNLPHAQVRFVWLRGRRATS
HWLTLPALKAFGAIPVADERIVHQDNIVTSAGVSAGLDLALWLAGQLGGEARAKAIQL
AIEYDPQPPFDSGHMSKASPTTKAAATALLSKDSAKPANLTAATLLAWERALAAVQSR
RRKRQPVGAQARRP"
gene complement(2182460..2183239)
/locus_tag="Rv1931c"
CDS complement(2182460..2183239)
/codon_start=1
/transl_table=11
/locus_tag="Rv1931c"
/product="Probable transcriptional regulatory protein"
/note="Rv1931c, (MTCY09F9.33), len: 259 aa. Probable
transcriptional regulatory protein. Similarity in
C-terminal half to transcriptional activators e.g. Q43970
AraC-like protein (227 aa), FASTA scores: opt: 238, E():
7.1e-07, (42.4% identity in 92 aa overlap). Similar to
many probable transcription regulators in Streptomyces
e.g. AL049587|SC5F2A.29 Streptomyces coelicolor (325 aa),
FASTA scores: opt: 387, E(): 3.2e-16, (34.4% identity in
259 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1931c"
/db_xref="EnsemblGenomes-Tr:CCP44698"
/db_xref="GOA:P95283"
/db_xref="InterPro:IPR002818"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR018060"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:P95283"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44698.1"
/translation="MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARR
VVTVCTGAFLAAEAGLLGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRG
WSHRRHRPRAGTGRRRPRHRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPP
GAGGHRGRAGGAHRIGELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLE
ETHDTVVAIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA"
gene 2183372..2183869
/gene="tpx"
/gene_synonym="cfp20"
/locus_tag="Rv1932"
CDS 2183372..2183869
/codon_start=1
/transl_table=11
/gene="tpx"
/gene_synonym="cfp20"
/locus_tag="Rv1932"
/product="Probable thiol peroxidase Tpx"
/note="Rv1932, (MTCY09F9.32c), len: 165 aa. Probable tpx
(alternate gene name: cfp20), thiol peroxidase similar to
TPX_ECOLI|P37901 thiol peroxidase (p20) from Escherichia
coli (167 aa), fasta scores: opt: 535, E(): 7.3e-25,
(52.4% identity in 164 aa overlap). There are four other
related enzymes in M. tuberculosis: Rv2428, Rv2521,
Rv2238c,Rv1608c."
/db_xref="EnsemblGenomes-Gn:Rv1932"
/db_xref="EnsemblGenomes-Tr:CCP44699"
/db_xref="GOA:P9WG35"
/db_xref="InterPro:IPR002065"
/db_xref="InterPro:IPR013740"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR018219"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:1XVQ"
/db_xref="PDB:1Y25"
/db_xref="UniProtKB/Swiss-Prot:P9WG35"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44699.1"
/translation="MAQITLRGNAINTVGELPAVGSPAPAFTLTGGDLGVISSDQFRG
KSVLLNIFPSVDTPVCATSVRTFDERAAASGATVLCVSKDLPFAQKRFCGAEGTENVM
PASAFRDSFGEDYGVTIADGPMAGLLARAIVVIGADGNVAYTELVPEIAQEPNYEAAL
AALGA"
gene complement(2183866..2184957)
/gene="fadE18"
/locus_tag="Rv1933c"
CDS complement(2183866..2184957)
/codon_start=1
/transl_table=11
/gene="fadE18"
/locus_tag="Rv1933c"
/product="Probable acyl-CoA dehydrogenase FadE18"
/note="Rv1933c, (MTCY09F9.31), len: 363 aa. Probable
fadE18, acyl-CoA dehydrogenase, similar to many e.g.
CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from
Streptomyces coelicolor (362 aa); NP_421282.1|NC_002696
acyl-CoA dehydrogenase family protein from Caulobacter
crescentus (344 aa); ACDS_RAT|P15651 short-chain specific
acyl-CoA dehydrogenase from Rattus norvegicus (Rat) (412
aa), fasta scores: opt: 239, E(): 2.1e-08, (28.4% identity
in 331 aa overlap); etc. Also similar to others from
Mycobacterium tuberculosis e.g. N-terminus of fadE22 (721
aa); fadE33 (318 aa); N-terminus of fadE34 (711 aa); etc.
Could belong to the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv1933c"
/db_xref="EnsemblGenomes-Tr:CCP44700"
/db_xref="GOA:P95281"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P95281"
/protein_id="CCP44700.1"
/translation="MDFRYSTEQDDFRASLRGFLGRGAPVREMAAADGSDRRLWQRLC
TELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAATVFAIEAILRMGDDEQ
RKRLLAGLLTGARIGTIAVSGHDVASATTVRAVRRDGRPALTGECTPVLHGHVADLFV
VPAVADGSIVLHVVAADAPGVTVTPLPSFDITRPVATLRLAGSPAEPLTAGTPDDMER
VLDVARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIEIDAT
RATVMFAAMSAANGDELQTVAPLAKAQTAETFVLCAGSALQIHGAIAFTWEHDLHLYY
RRAKTTEALFGSSARNRALLAERAGLVKA"
gene complement(2184959..2186188)
/gene="fadE17"
/locus_tag="Rv1934c"
CDS complement(2184959..2186188)
/codon_start=1
/transl_table=11
/gene="fadE17"
/locus_tag="Rv1934c"
/product="Probable acyl-CoA dehydrogenase FadE17"
/note="Rv1934c, (MTCY09F9.30), len: 409 aa. Probable
fadE17, acyl-CoA dehydrogenase, highly similar to
ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium
leprae (389 aa), FASTA scores: opt: 414, E():
2.6e-19,(28.3% identity in 407 aa overlap). Also similar
to many e.g. NP_249713.1|NC_002516 probable acyl-CoA
dehydrogenase from Pseudomonas aeruginosa (381 aa);
NP_420614.1|NC_002696 acyl-CoA dehydrogenase family
protein from Caulobacter crescentus (355 aa);
CAB61610.1|AL133210 putative acyl-CoA dehydrogenase from
Streptomyces coelicolor (393 aa); etc. Also similar to
others from Mycobacterium tuberculosis e.g. fadE30 (385
aa); fadE31 (377 aa); C-terminus of fadE34 (711 aa); etc.
Could belong to the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv1934c"
/db_xref="EnsemblGenomes-Tr:CCP44701"
/db_xref="GOA:P95280"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/Swiss-Prot:P95280"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44701.1"
/translation="MDVSYPPEAEAFRDRIREFVAEHLPPGWPGPGALPPHEREEFAR
HWRRALAGAGLVAVSWPTEYGGGGLSPMEQVVLAEEFARAGAPERAENDLLGIDLLGN
TLIALGSEAQKRHFLPRILSGEHRWCQGFSEPEAGSDLASVRTRGVLDGDEWVINGHK
IWTSAGTTANWIFLLARTDPSAAKHRGLSFLLVPMDQPGVVVRPIVNAAGHSSFSEVF
LTDARTSAGNVVGRVGDGWSTAMTLLGFERGSHIATAAIDFERDLQRLCELARDRGLH
TDPRVRDGLAWCYARVQIMRYRGYRDLTLALTGRPPGAEAAITKVIWSEYFRRYTDLA
VEILGLEALGPRGPGNGGARLVPEAGTPNSPACWMDELLYARAATIYAGSSQIQRNVI
GERLLGLPKEPRPEVLC"
gene complement(2186203..2187159)
/gene="echA13"
/locus_tag="Rv1935c"
CDS complement(2186203..2187159)
/codon_start=1
/transl_table=11
/gene="echA13"
/locus_tag="Rv1935c"
/product="Possible enoyl-CoA hydratase EchA13 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv1935c, (MTCY09F9.29), len: 318 aa. Possible
echA13, enoyl-CoA hydratase, similar to others and various
enzymes e.g. CAC48381.1|Y16952 putative
enoyl-CoA-isomerase from Amycolatopsis mediterranei (269
aa); AAK18173.1|AF290950_5|AF290950|FadB1x enoyl-CoA
hydratase from Pseudomonas putida (257 aa);
AAF78820.1|AF042490 4-chlorobenzoyl CoA dehalogenase from
Arthrobacter sp. TM1 (276 aa); ECHM_RAT|P14604 enoyl-CoA
hydratase mitochondrial precursor from Rattus norvegicus
(Rat) (290 aa), FASTA scores: opt: 228, E(): 1.2e-08,
(31.0% identity in 258 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv1935c"
/db_xref="EnsemblGenomes-Tr:CCP44702"
/db_xref="GOA:P95279"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/Swiss-Prot:P95279"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44702.1"
/translation="MFVGRVGPVDRRSDGERSRRPREFEYIRYETIDDGRIAAITLDR
PKQRNAQTRGMLVELGAAFELAEADDTVRVVILRAAGPAFSAGHDLGSADDIRERSPG
PDQHPSYRCNGATFGGVESRNRQEWHYYFENTKRWRNLRKITIAQVHGAVLSAGLMLA
WCCDLIVASEDTVFADVVGTRLGMCGVEYFGHPWEFGPRKTKELLLTGDCIGADEAHA
LGMVSKVFPADELATSTIEFARRIAKVPTMAALLIKESVNQTVDAMGFSAALDGCFKI
HQLNHAHWGEVTGGKLSYGTVEYGLEDWRAAPQIRPAIKQRP"
gene 2187384..2188493
/locus_tag="Rv1936"
CDS 2187384..2188493
/codon_start=1
/transl_table=11
/locus_tag="Rv1936"
/product="Possible monooxygenase"
/note="Rv1936, (MTCY09F9.28c), len: 369 aa. Possible
monooxygenase, similar to LXA2_PHOLU|P23146 alkanal
monooxygenase alpha chain (362 aa), FASTA scores: opt:
196,E(): 6.3e-06, (22.3% identity in 373 aa overlap). Also
similar to many other Mycobacterium tuberculosis
hypothetical oxidoreductases and monooxygenases e.g.
Rv0953c, Rv0791c, Rv0132c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1936"
/db_xref="EnsemblGenomes-Tr:CCP44703"
/db_xref="GOA:P95278"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:P95278"
/protein_id="CCP44703.1"
/translation="MEIGIFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEH
FTVPWEPICAPDLLLAQALLRTQQIKLAPGAHLLPYHHPVELAHRVAYFDHLAQGRFM
LGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWTEDEPWEHRGKYWNANGIA
PMFEGLMRRHIKPYQKPHPPIGVTGFSAGSETLKLAGERGYIPMSLDLNTEYVATHWD
AVEEGALRSGRTPDRRDWRLVREVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFG
MTKFYKHNPSVPDDEVTPEYLAENTFVVGSVQTVVDKLEATYDQVGGFGHLLILGFDY
SDNPGPWKESLRLLAHEVMPRLNARLATKPATAVV"
gene 2188496..2191015
/locus_tag="Rv1937"
CDS 2188496..2191015
/codon_start=1
/transl_table=11
/locus_tag="Rv1937"
/product="Possible oxygenase"
/note="Rv1937, (MTCY09F9.27c), len: 839 aa. Possible
oxygenase, similar in N-terminus to N-terminal part
(approx. 350 aa) of dioxygenases (including
ring-hydroxylating dioxygenase electron transfer
components) and monooxygenases, e.g. AAC34815.1|AF071556
anthranilate dioxygenase reductase from Acinetobacter sp.
(343 aa); AAK52291.1|AY026914|AntC putative anthranilate
dioxygenase reductase from Pseudomonas putida (340 aa);
AAF63450.1|AF218267_7|AF218267 benzoate dioxygenase /
ferredoxin reductase from Pseudomonas putida (336 aa);
P23101|XYLZ_PSEPU toluate 1,2-dioxygenase electron
transfer component [includes: ferredoxin;
ferredoxin--NAD(+) reductase ] from Pseudomonas putida
plasmid TOL pWW0 (336 aa), FASTA scores: opt: 700, E(): 0,
(34.3% identity in 335 aa overlap); S23479 probable
benzoate 1,2-dioxygenase reductase component benC from
Acinetobacter calcoaceticus (338 aa); AAC45294.1|U81594
soluble methane monooxygenase protein C from Methylocystis
sp. (343 aa); P22868|MEMC_METCA methane monooxygenase
component C from Methylococcus capsulatus (348 aa); etc.
Also similar in part to Mycobacterium tuberculosis
hypothetical electron transfer proteins Rv3554, Rv3571,
etc. Contains PS00197 2Fe-2S ferredoxins, iron-sulfur
binding region signature."
/db_xref="EnsemblGenomes-Gn:Rv1937"
/db_xref="EnsemblGenomes-Tr:CCP44704"
/db_xref="GOA:P95277"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR001433"
/db_xref="InterPro:IPR006058"
/db_xref="InterPro:IPR008333"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR036010"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR039261"
/db_xref="UniProtKB/TrEMBL:P95277"
/inference="protein motif:PROSITE:PS00197"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44704.1"
/translation="MAVRQVTVGYSDGTHKTMPVRCDQTVLDAAEEHGVAIVNECQSG
ICGTCVATCTAGRYQMGRTEGLSDVERAARKILTCQTFVTSDCRIELQYPVDDNAALL
VTGDGVVTAVELVSPSTAILRVDTSGMAGALRYRAGQFAQLQVPGTNVWRNYSYAHPA
DGRGECEFIIRLLPDGVMSNYLRDRAQPGDHIALRCSKGSFYLRPIVRPVILVAGGTG
LSAILAMAQSLDADVAHPVYLLYGVERTEDLCKLDELTELRRRVGRLEVHVVVARPDP
DWDGRTGLVTDLLDERMLASGDADVYLCGPVAMVDAARTWLDHNGFHRVGLYYEKFVA
SGAARRRTPARLDYAGVDIAEVCRRGRGTAVVIGGSIAGIAAAKMLSETFDRVIVLEK
DGPHRRREGRPGAAQGWHLHHLLTAGQIELERIFPGIVDDMVREGAFKVDMAAQYRIR
LGGTWKKPGTSDIEIVCAGRPLLEWCVRRRLDDEPRIDFRYESEVADLAFDRANNAIV
GVAVDNGDADGGDGLQVVPAEFVVDASGKNTRVPEFLERLGVGAPEAEQDIINCFYST
MQHRVPPERRWQDKVMVICYAYRPFEDTYAAQYYTDSSRTILSTSLVAYNCYSPPRTA
REFRAFADLMPSPVIGENIDGLEPASPIYNFRYPNMLRLRYEKKRNLPRALLAVGDAY
TSADPVSGLGMSLALKEVREMQALLAKYGAGHRDLPRRYYRAIAKMADTAWFVIREQN
LRFDWMKDVDKKRPFYFGVLTWYMDRVLELVHDDLDAYREFLAVVHLVKPPSALMRPR
IASRVLGKWARTRLSGQKTLIARNYENHPIPAEPADQLVNA"
gene 2191027..2192097
/gene="ephB"
/locus_tag="Rv1938"
CDS 2191027..2192097
/codon_start=1
/transl_table=11
/gene="ephB"
/locus_tag="Rv1938"
/product="Probable epoxide hydrolase EphB (epoxide
hydratase)"
/note="Rv1938, (MTCY09F9.26c), len: 356 aa. Probable
ephB,epoxide hydrolase (see citation below), similar to
many e.g. G1109600 ATSEH (321 aa), FASTA scores: opt: 442,
E(): 1.2e-21 (33.1% identity in 356 aa overlap); etc. Also
similar to many other M. tuberculosis hypothetical epoxide
hydrolases e.g. Rv3617, Rv3670, Rv0134, etc."
/db_xref="EnsemblGenomes-Gn:Rv1938"
/db_xref="EnsemblGenomes-Tr:CCP44705"
/db_xref="GOA:I6YC03"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:I6YC03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44705.1"
/translation="MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWYSWR
HQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGDVVGVLDSYGAEQAFVVG
HDWGAPVAWTFAWLHPDRCAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPG
RVWYQDYFAVQDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPI
DVIRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNID
NDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMPNYRGTHMIADVGHW
IQQEAPEETNRLLLDFLGGLRP"
gene 2192094..2192609
/locus_tag="Rv1939"
CDS 2192094..2192609
/codon_start=1
/transl_table=11
/locus_tag="Rv1939"
/product="Probable oxidoreductase"
/note="Rv1939, (MTCY09F9.25c), len: 171 aa. Probable
oxidoreductase, similar to NP_302637.1|NC_002677 probable
oxidoreductase from Mycobacterium leprae (162 aa) Also
similar to NTAB_CHELE|P54990 nitrilotriacetate
monooxygenase component from Chelatobacter heintzii (322
aa), fasta scores: opt: 269, E(): 5.3e-11, (33.1% identity
in 151 aa overlap). And similar to Mycobacterium
tuberculosis probable monooxygenase components
Rv0246,Rv3567, and to a lesser extent, Rv3007c."
/db_xref="EnsemblGenomes-Gn:Rv1939"
/db_xref="EnsemblGenomes-Tr:CCP44706"
/db_xref="GOA:P95275"
/db_xref="InterPro:IPR002563"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/TrEMBL:P95275"
/protein_id="CCP44706.1"
/translation="MSCTFDMVPETVDHLDEVGLRRVFGCFPCGVIAVCAMVDDQPVG
MAASSFTSVSVDPPLVSICVQNCSTTWPKLRDRPRLGVSVLAEGHDAACMSLSRKEGN
RFAGVFWSELSSGGVVIAGAGAWLDCRPYAEIPAGDHLIALLEICAVRADPETPPLVF
HGSRFRRLESR"
gene 2192606..2193667
/gene="ribA1"
/gene_synonym="ribA"
/locus_tag="Rv1940"
CDS 2192606..2193667
/codon_start=1
/transl_table=11
/gene="ribA1"
/gene_synonym="ribA"
/locus_tag="Rv1940"
/product="Probable riboflavin biosynthesis protein RibA1
(GTP cyclohydrolase II)"
/note="Rv1940, (MTCY09F9.24c), len: 353 aa. Probable
ribA1,Riboflavin biosynthesis protein, similar to
GCH2_BACSU|P17620 gtp cyclohydrolase II (398 aa), FASTA
scores: opt: 682, E(): 0, (37.7% identity in 363 aa
overlap), also similar to Rv1415|MTCY21B4.33|ribA2 (428
aa) (45.4% identity in 368 aa overlap). Note that
previously known as ribA."
/db_xref="EnsemblGenomes-Gn:Rv1940"
/db_xref="EnsemblGenomes-Tr:CCP44707"
/db_xref="GOA:L7N669"
/db_xref="InterPro:IPR000422"
/db_xref="InterPro:IPR017945"
/db_xref="InterPro:IPR032677"
/db_xref="InterPro:IPR036144"
/db_xref="UniProtKB/TrEMBL:L7N669"
/protein_id="CCP44707.1"
/translation="MKTTDVRVRRAITAMAGGHAVVLTGDPNGDGYLVFAAQAATPRL
VAFAVRHTSGYLRVALPGAECERLHLPPMCDRDTTHCVSVDVRGTGTGISASDRAWTI
AALASATSVAADFQRPGHVVPVQAQADGVLGRRGPAEAAVDLARLAERRPAAALCEIV
SPDNPVQMAHHAESVEFAVEHGLAMVSIGELVAYRRRIEPQVVRFTAATLPTWAGASR
VIGFRDVYDLGEHLAVIVGAVGAGVPVPLHVHIECLTGDVFGSTACRCGEELNGALAR
MSAQGSGVVLYLRPPGPAQACGLFARGDAATDVMPETVTWILRDLGVYAIRLSDDVPG
FGLVMFGAIREASTLAAAG"
gene 2193664..2194434
/locus_tag="Rv1941"
CDS 2193664..2194434
/codon_start=1
/transl_table=11
/locus_tag="Rv1941"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv1941, (MTCY09F9.23c), len: 256 aa. Probable
short-chain dehydrogenase/reductase, similar to various
dehydrogenases/reductases, generally belonging to SDR
family, e.g. NP_299015.1|NC_002488
2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase
from Xylella fastidiosa (255 aa); NP_250340.1|NC_002516
probable short-chain dehydrogenase from Pseudomonas
aeruginosa (253 aa); NP_106890.1|NC_002678 probable
short-chain type dehydrogenase/reductase from
Mesorhizobium loti (374 aa) (has its N-terminus longter);
P50197|LINC_PSEPA 2,5-dichloro-2,5-cyclohexadiene-1,4-
dehydrogenase from Pseudomonas paucimobilis (Sphingomonas
paucimobilis) (250 aa), FASTA scores: opt: 529, E():
5.7e-25, (40.6% identity in 251 aa overlap); etc. Contains
PS00061 Short-chain alcohol dehydrogenase family
signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv1941"
/db_xref="EnsemblGenomes-Tr:CCP44708"
/db_xref="GOA:I6XZC4"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:3GVC"
/db_xref="UniProtKB/TrEMBL:I6XZC4"
/inference="protein motif:PROSITE:PS00061"
/protein_id="CCP44708.1"
/translation="MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDA
ADAAATKIGCGAAACRVDVSDEQQIIAMVDACVAAFGGVDKLVANAGVVHLASLIDTT
VEDFDRVIAINLRGAWLCTKHAAPRMIERGGGAIVNLSSLAGQVAVGGTGAYGMSKAG
IIQLSRITAAELRSSGIRSNTLLPAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGR
MAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW"
gene complement(2194644..2194973)
/gene="mazF5"
/gene_synonym="mt5"
/locus_tag="Rv1942c"
CDS complement(2194644..2194973)
/codon_start=1
/transl_table=11
/gene="mazF5"
/gene_synonym="mt5"
/locus_tag="Rv1942c"
/product="Possible toxin MazF5"
/note="Rv1942c, (MTCY09F9.22), len: 109 aa. Possible
mazF5,toxin, part of toxin-antitoxin (TA) operon with
Rv1943c (See Pandey and Gerdes, 2005; Zhu et al., 2006),
shows some similarity to Q10867|MTCY39.28|Rv1991
hypothetical 12.3 kDa protein (114 aa), FASTA scores: opt:
117, E(): 0.021, (24. 5% identity in 110 aa overlap) also
P33645|CHPA_ECOLI pemk-like protein 1 (mazf protein) from
Escherichia coli (111 aa), FASTA scores: opt: 104, E():
0.18, (29.1% identity in 110 aa overlap). Also similar to
Mycobacterium tuberculosis Rv0659c (102 aa) (32.7%
identity in 101 aa overlap); Rv1102c (33.3% identity in 93
aa overlap) and Rv1495."
/db_xref="EnsemblGenomes-Gn:Rv1942c"
/db_xref="EnsemblGenomes-Tr:CCP44709"
/db_xref="GOA:P95272"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="UniProtKB/Swiss-Prot:P95272"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44709.1"
/translation="MTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCT
TTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVAVLVNRLGRLADIRMRAICTALE
VAVDCSR"
gene complement(2194970..2195347)
/gene="mazE5"
/locus_tag="Rv1943c"
CDS complement(2194970..2195347)
/codon_start=1
/transl_table=11
/gene="mazE5"
/locus_tag="Rv1943c"
/product="Possible antitoxin MazE5"
/note="Rv1943c, (MTCY09F9.21), len: 125 aa. Possible
mazE5,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1942c (See Pandey and Gerdes, 2005; Zhu et al., 2006),
shows some similarity with Rv1946c|MTCY09F9.18|lppG
possible conserved lipoprotein from Mycobacterium
tuberculosis (150 aa), FASTA score: (71.4% identity in 28
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1943c"
/db_xref="EnsemblGenomes-Tr:CCP44710"
/db_xref="GOA:P9WJ89"
/db_xref="UniProtKB/Swiss-Prot:P9WJ89"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44710.1"
/translation="MKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWH
SSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDEALAALLARHRSAEVDASYAAYD
KHPVDEPDEWGDLASWRRAAGDS"
gene complement(2195344..2195934)
/locus_tag="Rv1944c"
CDS complement(2195344..2195934)
/codon_start=1
/transl_table=11
/locus_tag="Rv1944c"
/product="Conserved protein"
/note="Rv1944c, (MTCY09F9.20), len: 196 aa. Conserved
protein, similar to C-terminal part of
SCE20.29|AL136058|CAB65585.1 hypothetical protein from
Streptomyces coelicolor (338 aa), blastp scores,
Identities = 37/131 (28%), Positives = 51/131 (38%)."
/db_xref="EnsemblGenomes-Gn:Rv1944c"
/db_xref="EnsemblGenomes-Tr:CCP44711"
/db_xref="InterPro:IPR004027"
/db_xref="UniProtKB/TrEMBL:P95270"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44711.1"
/translation="MISDTEDFAHGDKAAPPRLRASYAACGGDAAGCWTMSDNGASRV
PPVDETPAAESAEPITAVSLAWLPAGDYERALDLWPDFAGSDLVTGPDGPVAHPLYCR
RMQQKLVEFAEAGFPGLAVAAIRVAPFAAWCAEQGQEPDSPEARAEYAAYLTAHGDHD
VMAWPPGRNQQCWCGSGHKYKKCCAAASFIDTEPAP"
gene 2195989..2197353
/locus_tag="Rv1945"
CDS 2195989..2197353
/codon_start=1
/transl_table=11
/locus_tag="Rv1945"
/product="Conserved hypothetical protein"
/note="Rv1945, (MTCY09F9.19c), len: 454 aa. Member of
Mycobacterium tuberculosis REP13E12 repeat family. Similar
to several others, best with Rv1148c|Z95584|MTCI65.15 (482
aa), FASTA score: opt: 2954, E(): 0, (97.1% identity in
454 aa overlap). Contains possible helix-turn-helix motif
at aa 74-95 (+2.90 SD)."
/db_xref="EnsemblGenomes-Gn:Rv1945"
/db_xref="EnsemblGenomes-Tr:CCP44712"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P9WLQ5"
/protein_id="CCP44712.1"
/translation="MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLE
VERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGER
RALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAEL
ATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPEL
RATIEAVLAKLAAPGACNPDDQTPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLL
ASGELGQHRGLPVTVVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASNAHHYLALF
DGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDI
NDLTLACGPDNRLVEKGWKTRKNAKGDTEWLPPAHLDHGQPRINRYHHPEKILCEPDD
DEPH"
repeat_region 2195989..2197350
/locus_tag="Rv1945"
/note="REP-7, len: 1362 nt. REP09F9, member of the
REP13E12 family. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene complement(2197508..2197960)
/gene="lppG"
/locus_tag="Rv1946c"
CDS complement(2197508..2197960)
/codon_start=1
/transl_table=11
/gene="lppG"
/locus_tag="Rv1946c"
/product="Possible lipoprotein"
/note="Rv1946c, (MTCY09F9.18), len: 150 aa. Possible
lppG,conserved lipoprotein, showing some similarity to
Rv1943c|MTCY09F9.21 conserved hypothetical protein from
Mycobacterium tuberculosis (125 aa), FASTA score: (71.4%
identity in 28 aa overlap). Contains PS00013 Prokaryotic
membrane lipoprotein lipid attachment site. This region is
a possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1946c"
/db_xref="EnsemblGenomes-Tr:CCP44713"
/db_xref="UniProtKB/TrEMBL:P95268"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP44713.1"
/translation="MIRGSAVSGLLMPSVNGGTAGSVACVQCLFLPKVAVDLINLSGI
QCFARIEHVAHAQAHPFVVLVGKPAQHGARIGAVAGAILTGDVIVSHDGELYRAVTAL
RQNGPRPHASRRLHAPALCSARSRRGHLRPSCWLPPPRFAGRQSLVAR"
gene 2198024..2198425
/locus_tag="Rv1947"
CDS 2198024..2198425
/codon_start=1
/transl_table=11
/locus_tag="Rv1947"
/product="Hypothetical protein"
/note="Rv1947, (MTCY09F9.17c), len: 133 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1947"
/db_xref="EnsemblGenomes-Tr:CCP44714"
/db_xref="UniProtKB/TrEMBL:P95267"
/protein_id="CCP44714.1"
/translation="MDRYNDQASGRALIEIRLCNERATPMPIPIGLWMFQTKLHVNAG
GADVFLPVCDVLEQDLAERDEEVRQLNLQYRNRLEYAIGRTCSAAWSVNGSRRPSAVW
TTWLPVAETPHTRARSVENALLSMDSRGGVT"
gene complement(2198714..2199064)
/locus_tag="Rv1948c"
CDS complement(2198714..2199064)
/codon_start=1
/transl_table=11
/locus_tag="Rv1948c"
/product="Hypothetical protein"
/note="Rv1948c, (MTCY09F9.16), len: 116 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1948c"
/db_xref="EnsemblGenomes-Tr:CCP44715"
/db_xref="UniProtKB/TrEMBL:P95266"
/protein_id="CCP44715.1"
/translation="MTVFGIKPDNYFGDVVLAAADRDGLRIFQYAVRSAHESGQATFD
IDGVQQRIVRESGTADMELGSQTVVWRFDDTKLVEILDKLSPLIDGEGPGHQYIDDLN
SPAPTLMISVDEYA"
gene complement(2199075..>2200034)
/locus_tag="Rv1949c"
CDS complement(2199075..>2200034)
/codon_start=1
/transl_table=11
/locus_tag="Rv1949c"
/product="Conserved hypothetical protein"
/note="Rv1949c, (MTCY09F9.15), len: 319 aa. Conserved
hypothetical protein, partial ORF. Rv1949c and
Rv1950c|MTCY09F9.14 are similar but frameshifted with
respect to Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kd
protein (323 aa), FASTA scores: opt: 459, E():
2.8e-16,(54.8% identity in 157 aa overlap). Cosmid
sequence appears to be correct, genomic sequence is also
frameshifted in Mycobacterium bovis strain AF2122/97.
Similar to Mycobacterium tuberculosis hypothetical
proteins: Rv2542,Rv2077c, Rv2797c, Rv0963c, etc."
/db_xref="EnsemblGenomes-Gn:Rv1949c"
/db_xref="EnsemblGenomes-Tr:CCP44716"
/db_xref="UniProtKB/TrEMBL:L0T9Q6"
/protein_id="CCP44716.1"
/translation="WLRQRTGADLQIVSGIAEHLRQASGLAREGAGTIGAAQRRVIYA
VQDAHNAGFNVEEDLSVTDTRTSRTFAEQAARQAQAQALAGDIRQRATQLIGVEHEVA
AKIATATAPLNTVGFHEPPIAPSLPTPVPHNEKPQIHAVDRSWKQDPPSPMPGDPKDM
TAVQARAAWDAVNADIARYNARCGRTFVLPNEQAAYDACIADKGSLFERQAAIRARLG
ELGVPVEGEPPPAPDPAGPQPNEGLPPPGVSPPAESNLTVGPPSRPIQQARGGESLWD
ENGGEWRYFPGDNYRYPHWDYNPHDSPTARWQNIPIGDLPTHK"
gene complement(2199998..2200189)
/locus_tag="Rv1950c"
CDS complement(2199998..2200189)
/codon_start=1
/transl_table=11
/locus_tag="Rv1950c"
/product="Conserved hypothetical protein"
/note="Rv1950c, (MTCY09F9.14), len: 63 aa. Conserved
hypothetical protein, partial ORF. Highly similar to
N-terminus of Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3
kDa protein (323 aa), FASTA scores: opt: 280, E(): 1.2
e-16, (71.7% identity in 53 aa overlap) but homology
continues in different frame ie MTCY09F9.15, cosmid
sequence appears to be correct, genomic sequence is also
frameshifted in Mycobacterium bovis strain AF2122/97."
/db_xref="EnsemblGenomes-Gn:Rv1950c"
/db_xref="EnsemblGenomes-Tr:CCP44717"
/db_xref="UniProtKB/TrEMBL:P95264"
/protein_id="CCP44717.1"
/translation="MLPTLSHIHAWDTEHLIEAAYYWTKVADQWEDVFLEMRNRSHFI
AWEGAGGDGCDSEPALTYR"
gene complement(2200190..2200486)
/locus_tag="Rv1951c"
CDS complement(2200190..2200486)
/codon_start=1
/transl_table=11
/locus_tag="Rv1951c"
/product="Conserved hypothetical protein"
/note="Rv1951c, (MTCY09F9.13), len: 98 aa. Conserved
hypothetical protein, similar to Mycobacterium
tuberculosis hypothetical protein Rv2541 (135 aa) (40.9%
identity in 88 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1951c"
/db_xref="EnsemblGenomes-Tr:CCP44718"
/db_xref="UniProtKB/TrEMBL:P95263"
/protein_id="CCP44718.1"
/translation="MKAGELRVNIQQVAATASQWSGRSTELSVLAPPPLGQPFQPTTA
AVGGAHAAVGLAVAAFTARTHATASAVEAAAAEYANNEAAAAAEMAAVPQTRLV"
gene 2200726..2200941
/gene="vapB14"
/locus_tag="Rv1952"
CDS 2200726..2200941
/codon_start=1
/transl_table=11
/gene="vapB14"
/locus_tag="Rv1952"
/product="Possible antitoxin VapB14"
/note="Rv1952, (MTCY09F9.12c), len: 71 aa. Possible
vapB14,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1953 (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Similar to others in M. tuberculosis e.g. Rv2601A. Some
similarity to P55510|Y4JJ_RHISN putative plasmid stability
protein (85 aa), FASTA scores: opt: 127, E(): 0.00096,
(42.5% identity in 73 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1952"
/db_xref="EnsemblGenomes-Tr:CCP44719"
/db_xref="GOA:P95262"
/db_xref="InterPro:IPR010985"
/db_xref="InterPro:IPR013321"
/db_xref="UniProtKB/Swiss-Prot:P95262"
/protein_id="CCP44719.1"
/translation="MIRNLPEGTKAALRVRAARHHHSVEAEARAILTAGLLGEEVPMP
VLLAADSGHDIDFEPERLGLIARTPQL"
gene 2200938..2201249
/gene="vapC14"
/locus_tag="Rv1953"
CDS 2200938..2201249
/codon_start=1
/transl_table=11
/gene="vapC14"
/locus_tag="Rv1953"
/product="Possible toxin VapC14"
/note="Rv1953, (MTCY09F9.11c), len: 103 aa. Possible
vapC14, toxin, part of toxin-antitoxin (TA) operon with
Rv1952, contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Some similarity to O33827
plasmid stability-like protein from Thiobacillus
ferrooxidans (143 aa), FASTA scores: opt: 170, E():
3.5e-06, (45.3% identity in 75 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1953"
/db_xref="EnsemblGenomes-Tr:CCP44720"
/db_xref="GOA:P9WF99"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF99"
/protein_id="CCP44720.1"
/translation="MTYVLDTNVVSALRVPGRHPAVAAWADSVQVAEQFVVAITLAEI
ERGVIAKERTDPTQSEHLRRWFDDKVLRIFVFARRGTNLIMQPLAGHIGYSLYSGISW
F"
gene complement(2201223..2201744)
/locus_tag="Rv1954c"
CDS complement(2201223..2201744)
/codon_start=1
/transl_table=11
/locus_tag="Rv1954c"
/product="Hypothetical protein"
/note="Rv1954c, (MTCY09F9.10), len: 173 aa. Hypothetical
unknown protein, end overlaps next ORF upstream, Rv1955
(MTCY09F9.09c)."
/db_xref="EnsemblGenomes-Gn:Rv1954c"
/db_xref="EnsemblGenomes-Tr:CCP44721"
/db_xref="UniProtKB/Swiss-Prot:P9WLQ3"
/protein_id="CCP44721.1"
/translation="MAAGSGGGTVGLVLPRVASLSGLDGAPTVPEGSDKALMHLGDPP
RRCDTHPDGTSSAAAALVLRRIDVHPLLTGLGRGRQTVSLRNGHLVATANRAILSRRR
SRLTRGRSFTSHLITSCPRLDDHQHRHPTRCRAEHAGCTVATCIPNAHDPAPGHQTPR
WGPFRLKPAYTRI"
gene 2201277..2201579
/locus_tag="Rv1954A"
CDS 2201277..2201579
/codon_start=1
/transl_table=11
/locus_tag="Rv1954A"
/product="Hypothetical protein"
/note="Rv1954A, len: 100 aa. Hypothetical unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1954A"
/db_xref="EnsemblGenomes-Tr:CCP44722"
/db_xref="UniProtKB/Swiss-Prot:P0CV86"
/protein_id="CCP44722.1"
/translation="MARGRVVCIGDAGCDCTPGVFRATAGGMPVLVVIESGTGGDQMA
RKATSPGKPAPTSGQYRPVGGGNEVTVPKGHRLPPSPKPGQKWVNVDPTKNKSGRG"
gene 2201719..2202096
/gene="higB"
/locus_tag="Rv1955"
CDS 2201719..2202096
/codon_start=1
/transl_table=11
/gene="higB"
/locus_tag="Rv1955"
/product="Possible toxin HigB"
/note="Rv1955, (MTCY09F9.09c), len: 125 aa. Possible
higB,toxin, part of toxin-antitoxin (TA) operon with
Rv1956 (See Pandey and Gerdes, 2005; Gupta, 2009). Start
overlaps another ORF, Rv1954c (MTCY09F9.10). Start changed
since first submission (-45 aa). Predicted to be an outer
membrane protein (See Song et al., 2008). Upon expression
in E. coli has been shown to function as an antitoxin
against Rv1956 (PubMed: 19016878); It is not clear if
these conflicting results are due to expression in a
heterologous system; In various publications, both gene
names higA and higB have been assigned to both Rv1955 and
Rv1956; we have chosen to call Rv1955 higB after
consulting the authors."
/db_xref="EnsemblGenomes-Gn:Rv1955"
/db_xref="EnsemblGenomes-Tr:CCP44723"
/db_xref="GOA:P9WJA5"
/db_xref="InterPro:IPR009241"
/db_xref="UniProtKB/Swiss-Prot:P9WJA5"
/protein_id="CCP44723.1"
/translation="MPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLM
QRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLFFRWGQHPVALTAFYKNQQKTPK
TKIETALDRQKIWKRAFGDTPPI"
gene 2202138..2202587
/gene="higA"
/locus_tag="Rv1956"
CDS 2202138..2202587
/codon_start=1
/transl_table=11
/gene="higA"
/locus_tag="Rv1956"
/product="Possible antitoxin HigA"
/note="Rv1956, (MTCY09F9.08c), len: 149 aa. Possible
higA,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1955 (See Pandey and Gerdes, 2005; Gupta, 2009).
Possible transcriptional regulatory protein, contains
probable helix-turn-helix motif at aa 52-73 (+4.78 SD).
Upon expression in E.coli Rv1956 has been shown to
function as a toxin inhibiting cell growth and colony
formation that is neutralized by coexpression with Rv1955
(PubMed: 19016878); It is not clear if these conflicting
results are due to expression in a heterologous system.
The gene names higA and higB have been assigned to both
Rv1955 and Rv1956; we have chosen to call Rv1956 higA
after consulting the authors."
/db_xref="EnsemblGenomes-Gn:Rv1956"
/db_xref="EnsemblGenomes-Tr:CCP44724"
/db_xref="GOA:P9WJA7"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010982"
/db_xref="PDB:5MTW"
/db_xref="UniProtKB/Swiss-Prot:P9WJA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44724.1"
/translation="MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIA
LRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLSTLQRYARALDARLRLVLEVPTL
REVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA"
gene 2202584..2203129
/locus_tag="Rv1957"
CDS 2202584..2203129
/codon_start=1
/transl_table=11
/locus_tag="Rv1957"
/product="Hypothetical protein"
/note="Rv1957, (MTCY09F9.07c), len: 181 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1957"
/db_xref="EnsemblGenomes-Tr:CCP44725"
/db_xref="GOA:P95257"
/db_xref="InterPro:IPR035958"
/db_xref="PDB:5MTW"
/db_xref="UniProtKB/Swiss-Prot:P95257"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44725.1"
/translation="MTDRTDADDLDLQRVGARLAARAQIRDIRLLRTQAAVHRAPKPA
QGLTYDLEFEPAVDADPATISAFVVRISCHLRIQNQAADDDVKEGDTKDETQDVATAD
FEFAALFDYHLQEGEDDPTEEELTAYAATTGRFALYPYIREYVYDLTGRLALPPLTLE
ILSRPMPVSPGAQWPATRGTP"
gene complement(2203018..2203632)
/locus_tag="Rv1958c"
CDS complement(2203018..2203632)
/codon_start=1
/transl_table=11
/locus_tag="Rv1958c"
/product="Hypothetical protein"
/note="Rv1958c, (MTCY09F9.06), len: 204 aa. Hypothetical
unknown protein, questionable ORF"
/db_xref="EnsemblGenomes-Gn:Rv1958c"
/db_xref="EnsemblGenomes-Tr:CCP44726"
/db_xref="UniProtKB/TrEMBL:P95256"
/protein_id="CCP44726.1"
/translation="MIPTPSIGAVINAKISHRACRTFPRPTDIHPRRYLPRKHGGTNP
RRLSMNPGGMRIRCRRGDKSRKLLSRSQVQPLVGRPAKIPSPAANAPPSRARTASPVF
ENLELRAAAGLAFGFRLRPFGGTAADSPPVAAQDLDPCRWADSPALHLAVGVETMVVG
QLDSPSFGQGVPLVAGHWAPGETGIGRDNISRVNGGSARRPVRS"
gene complement(2203681..2203977)
/gene="parE1"
/locus_tag="Rv1959c"
CDS complement(2203681..2203977)
/codon_start=1
/transl_table=11
/gene="parE1"
/locus_tag="Rv1959c"
/product="Possible toxin ParE1"
/note="Rv1959c, (MTCY09F9.05), len: 98 aa. Possible
parE1,toxin, part of toxin-antitoxin (TA) operon with
Rv1960c (See Pandey and Gerdes, 2005), similar to other
hypothetical plasmid proteins e.g. AL117189|YPCD1.08 from
Yersinia pestis (99 aa), FASTA scores: opt: 162, E():
7.3e-05, (33.0% identity in 91 aa overlap); also some
similarity to E145339 hypothetical protein (103 aa), FASTA
scores: opt: 142, E(): 0.0003, (33.0% identity in 91 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1959c"
/db_xref="EnsemblGenomes-Tr:CCP44727"
/db_xref="GOA:P9WHG7"
/db_xref="InterPro:IPR007712"
/db_xref="InterPro:IPR028344"
/db_xref="InterPro:IPR035093"
/db_xref="UniProtKB/Swiss-Prot:P9WHG7"
/protein_id="CCP44727.1"
/translation="MSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDR
AAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEGTIDVVRVLHQRMDVDRNL"
gene complement(2203974..2204225)
/gene="parD1"
/locus_tag="Rv1960c"
CDS complement(2203974..2204225)
/codon_start=1
/transl_table=11
/gene="parD1"
/locus_tag="Rv1960c"
/product="Possible antitoxin ParD1"
/note="Rv1960c, (MTCY09F9.04), len: 83 aa. Possible
parD1,antitoxin, part of toxin-antitoxin (TA) operon with
Rv1959c (See Pandey and Gerdes, 2005), similar to
O85269|AF102990|AF102990_51 hypothetical protein of
Yersinia enterocolitica (80 aa), FASTA scores: opt:
149,E(): 0.00037, (42.1% identity in 57 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1960c"
/db_xref="EnsemblGenomes-Tr:CCP44728"
/db_xref="GOA:P9WIJ7"
/db_xref="InterPro:IPR010985"
/db_xref="InterPro:IPR022789"
/db_xref="InterPro:IPR038296"
/db_xref="UniProtKB/Swiss-Prot:P9WIJ7"
/protein_id="CCP44728.1"
/translation="MGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRE
TQLRALREALEAGERSGSSTPFDFDGFLGRKRADASRGR"
gene 2204212..2204706
/locus_tag="Rv1961"
CDS 2204212..2204706
/codon_start=1
/transl_table=11
/locus_tag="Rv1961"
/product="Hypothetical protein"
/note="Rv1961, MTCY09F9.03c, len: 164 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv1961"
/db_xref="EnsemblGenomes-Tr:CCP44729"
/db_xref="UniProtKB/TrEMBL:P95253"
/protein_id="CCP44729.1"
/translation="MFLPTNAQYQLLVVGVSPWDTPSPSGRISWGSAWPHQARRAQTC
QRVRRHWMIDTTEAAYRLTYQPDGTSITVRENLVDILARELLGPIRGPQEVLPFSPRS
QYLVGHLAPVKLTGAALIDDNAVQARANAEALAEGGGVPAYAADETTPTPTTTPKTAH
PSRA"
gene complement(2204866..2205273)
/gene="vapC35"
/locus_tag="Rv1962c"
CDS complement(2204866..2205273)
/codon_start=1
/transl_table=11
/gene="vapC35"
/locus_tag="Rv1962c"
/product="Possible toxin VapC35. Contains PIN domain."
/note="Rv1962c, (MTCY09F9.02), len: 135 aa. Possible
vapC35, toxin, part of toxin-antitoxin (TA) operon with
Rv1962A, contains PIN domain, see Arcus et al. 2005.
Similar to others in Mycobacterium tuberculosis e.g.
Rv3408|MTCY78.20c (133 aa) (36.2% identity in 138 aa
overlap); and Rv3384c (130 aa) (43.1% identity in 130 aa
overlap)"
/db_xref="EnsemblGenomes-Gn:Rv1962c"
/db_xref="EnsemblGenomes-Tr:CCP44730"
/db_xref="GOA:P9WF67"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF67"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44730.1"
/translation="MIYLETSALVKLIRIEVESDALADWLDDRTELRWITSALTEVEL
SRAIRAVSPEGLPAVPSVLARLDRFEIDAVIRSTAAAYPNPALRSLDAIHLATAQTAG
SVAPLTALVTYDNRLKEAAEALSLAVVAPGQAR"
gene complement(2205277..2205549)
/gene="vapB35"
/locus_tag="Rv1962A"
CDS complement(2205277..2205549)
/codon_start=1
/transl_table=11
/gene="vapB35"
/locus_tag="Rv1962A"
/product="Possible antitoxin VapB35"
/note="Rv1962A, len: 90 aa. Possible vapB35,
antitoxin,part of toxin-antitoxin (TA) operon with
Rv1962c, see Arcus et al. 2005. Similar to others in M.
tuberculosis e.g. Rv3385c, Rv3407, Rv0626"
/db_xref="EnsemblGenomes-Gn:Rv1962A"
/db_xref="EnsemblGenomes-Tr:CCP44731"
/db_xref="GOA:P9WF17"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:P9WF17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44731.1"
/translation="MNEVSIRTLNQETSKVLARVKRGEEINLTERGKVIARIIPASAG
PLDSLISTGSVQPARVHGPAPRPTIPMRGGLDSGTLLERMRAEERY"
gene complement(2205582..2206802)
/gene="mce3R"
/locus_tag="Rv1963c"
CDS complement(2205582..2206802)
/codon_start=1
/transl_table=11
/gene="mce3R"
/locus_tag="Rv1963c"
/product="Probable transcriptional repressor (probably
TetR-family) Mce3R"
/note="Rv1963c, (MTV051.01c-MTCY09F9.01), len: 406 aa.
Probable mce3R, negative transcriptional regulatory
protein, TetR family (see citation below); similar to
several transcriptional regulator e.g. AL049485|SC6A5.30
Streptomyces coelicolor cosmid 6 a (404 aa), FASTA scores:
opt: 319, E(): 6.4e-13, (29.5% identity in 373 aa
overlap); and Z84498|MTCY9F9_1 (259 aa), FASTA scores:
opt: 208, E(): 1.6e-07, (100.0% identity in 32 aa
overlap). Contains probable helix-turn-helix at aa 36-57
(+4.23 SD) and two tet-R family signatures."
/db_xref="EnsemblGenomes-Gn:Rv1963c"
/db_xref="EnsemblGenomes-Tr:CCP44732"
/db_xref="GOA:P95251"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/Swiss-Prot:P95251"
/protein_id="CCP44732.1"
/translation="MASVAQPVRRRPKDRKKQILDQAVGLFIERGFHSVKLEDIAEAA
GVTARALYRHYDNKQALLAEAIRTGQDQYQSARRLTEGETEPTPRPLNADLEDLIAAA
VASRALTVLWQREARYLNEDDRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWA
VSSTLTSLGRHSLSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFS
RYETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEW
RCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELSHASVEVRDGYLRN
QGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIEDVARTWHLTRYAGVADEISGLA
LAILTSGAGNLLRA"
gene 2207700..2208497
/gene="yrbE3A"
/locus_tag="Rv1964"
CDS 2207700..2208497
/codon_start=1
/transl_table=11
/gene="yrbE3A"
/locus_tag="Rv1964"
/product="Conserved hypothetical integral membrane protein
YrbE3A"
/note="Rv1964, (MTV051.02), len: 265 aa.
YrbE3A,hypothetical unknown integral membrane protein,
part of mce3 operon and member of YrbE family (see
citations below), highly similar to Mycobacterium
tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265
aa),O07791|Rv0587|MTCY19H5.35|yrbE2A (265
aa),Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly
similar to conserved hypothetical integral membrane
proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A
from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from
Escherichia coli (260 aa), FASTA scores: opt: 893, E():
0,(51.4% identity in 253 aa overlap); etc. The
transcription of this CDS seems negatively regulated by
the product of Rv1963c|mce3R (see Santangelo et al.,
2002)."
/db_xref="EnsemblGenomes-Gn:Rv1964"
/db_xref="EnsemblGenomes-Tr:CCP44733"
/db_xref="GOA:O53965"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:O53965"
/protein_id="CCP44733.1"
/translation="MVIVADKAAGRVADPVLRPVGALGDFFAMTLDTSVCMFKPPFAW
REYLLQCWFVARVSTLPGVLMTIPWAVISGFLFNVLLTDIGAADFSGTGCAIFTVNQS
APIVTVLVVAGAGATAMCADLGARTIREELDALRVMGINPIQALAAPRVLAATTVSLA
LNSVVTATGLIGAFFCSVFLMHVSAGAWVTGLTTLTHTVDVVISMIKATLFGLMAGLI
ACYKGMSVGGGPAGVGRAVNETVVFAFIVLFVINIVVTAVGIPFMVS"
gene 2208507..2209322
/gene="yrbE3B"
/locus_tag="Rv1965"
CDS 2208507..2209322
/codon_start=1
/transl_table=11
/gene="yrbE3B"
/locus_tag="Rv1965"
/product="Conserved hypothetical integral membrane protein
YrbE3B"
/note="Rv1965, (MTV051.03), len: 271 aa.
YrbE4B,hypothetical unknown integral membrane protein,
part of mce3 operon and member of YrbE family (see
citations below), highly similar to Mycobacterium
tuberculosis proteins O07413|Rv0168|MTCI28.08|yrbE1B (289
aa), FASTA scores: opt: 937, E(): 0, (54.3% identity in
254 aa overlap); O07790|Rv0588|MTCY19H5.34|yrbE2B (295
aa); etc. Also highly similar to conserved hypothetical
integral membrane proteins of the yrbEB type, e.g.
AAD24545.1|AF116213|YrbE1B from Mycobacterium leprae (106
aa); P45392|YRBE_ECOLI hypothetical 27.9 kDa protein from
Escherichia coli (260 aa), FASTA scores: opt: 218, E():
1.2e-07, (24.1% identity in 245 aa overlap); etc. The
transcription of this CDS seems negatively regulated by
the product of Rv1963c|mce3R (see Santangelo et al.,
2002)."
/db_xref="EnsemblGenomes-Gn:Rv1965"
/db_xref="EnsemblGenomes-Tr:CCP44734"
/db_xref="GOA:O53966"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:O53966"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44734.1"
/translation="MTAAKALVSEWNRMGSQMRFFVGTLAGIPDALMHYRGELLRVIA
QMGLGTGVLAVIGGTVAIVGFLAMTTGAIVAVQGYNQFASVGVEALTGFASAFFNTRE
IQPGTVMVALAATVGAGTTAALGAMRINEEIDALEVIGIRSISYLASTRVLAGVVVAV
PLFCVGLMTAYLAARVGTTAIYGQGSGVYDHYFNTFLRPTDVLWSSVEVVVVALMIML
VCTYYGYAAHGGPAGVGEAVGRAVRASMVVASIAILVMTLAIYGQSPNFHLAT"
gene 2209327..2210604
/gene="mce3A"
/gene_synonym="mce3"
/locus_tag="Rv1966"
CDS 2209327..2210604
/codon_start=1
/transl_table=11
/gene="mce3A"
/gene_synonym="mce3"
/locus_tag="Rv1966"
/product="Mce-family protein Mce3A"
/note="Rv1966, (MTV051.04), len: 425 aa. Mce3A; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A
(454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa);
etc. Also highly similar to others e.g.
AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry
protein from Mycobacterium bovis BCG (454 aa);
NP_302656.1|NC_002677 putative cell invasion protein from
Mycobacterium leprae (441 aa); CAC12798.1|AL445327
putative secreted protein from Streptomyces coelicolor
(418 aa); etc. Contains a possible N-terminal signal
sequence or membrane anchor. Note that previously known as
mce3. The transcription of this CDS seems negatively
regulated by the product of Rv1963c|mce3R (see Santangelo
et al., 2002). Predicted to be an outer membrane protein
(See Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1966"
/db_xref="EnsemblGenomes-Tr:CCP44735"
/db_xref="GOA:L7N698"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="InterPro:IPR024516"
/db_xref="UniProtKB/TrEMBL:L7N698"
/protein_id="CCP44735.1"
/translation="MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPV
TLAADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEWAQNGASLRLEIDPDQIRYIPANV
EAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEINTVFENVVDLLNMID
PLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEALNARGDTIGGNWRSLKNFTDTYD
AAAQDILTILNAASTTSATVVNHSTQLDALLLNAIGLSNAGTNLLGSSRDNLVGAADI
LAPTTSLLFKYNPEYTCFLQGAKWYLDNGGYAAWGGADGRTLQLDVALLFGNDPYVYP
DNLPVVAAKGGPGGRPGCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWAN
YFPVTRAVPEPPSIRQCIPGPAIGPNPAAGEQP"
gene 2210601..2211629
/gene="mce3B"
/locus_tag="Rv1967"
CDS 2210601..2211629
/codon_start=1
/transl_table=11
/gene="mce3B"
/locus_tag="Rv1967"
/product="Mce-family protein Mce3B"
/note="Rv1967, (MTV051.05), len: 342 aa. Mce3B; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07414|Rv0170|MTCI28.10|mce1B (346
aa); O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); etc. Also
similar to others e.g. NP_302657.1|NC_002677 putative
secreted protein from Mycobacterium leprae (346 aa);
CAC12797.1|AL445327 putative secreted protein from
Streptomyces coelicolor (354 aa); etc. Contains a possible
N-terminal signal sequence or membrane anchor. The
transcription of this CDS seems negatively regulated by
the product of Rv1963c|mce3R (see Santangelo et al.,
2002). Predicted to be an outer membrane protein (See Song
et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1967"
/db_xref="EnsemblGenomes-Tr:CCP44736"
/db_xref="GOA:O53968"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O53968"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44736.1"
/translation="MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDGKTYYAE
FANVSNLRTGKLVRIAGVEVGKVTRISINPDATVRVQFTADNSVTLTRGTRAVIRYDN
LFGDRYLALEEGAGGLAVLRPGHTIPLARTQPALDLDALIGGFKPLFRALNPEQVNAL
SEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLIGQVITNLNVVLGSLGAHTDRLD
QAVTSLSALIHRLAQRKTDISNAVAYTNAAAGSVADLLSQARAPLAKVVRETDRVAGI
AAADHDYLDNLLNTLPDKYQALVRQGMYGDFFAFYLCDVVLKVNGKGGQPVYIKLAGQ
DSGRCAPK"
gene 2211626..2212858
/gene="mce3C"
/locus_tag="Rv1968"
CDS 2211626..2212858
/codon_start=1
/transl_table=11
/gene="mce3C"
/locus_tag="Rv1968"
/product="Mce-family protein Mce3C"
/note="Rv1968, (MTV051.06), len: 410 aa. Mce3C; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515
aa); O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); etc. Also
similar to others e.g. CAC12796.1|AL445327 putative
secreted protein from Streptomyces coelicolor (351 aa);
NP_302658.1|NC_002677 putative secreted protein from
Mycobacterium leprae (519 aa); etc. Contains a possible
N-terminal signal sequence or membrane anchor. The
transcription of this CDS seems negatively regulated by
the product of Rv1963c|mce3R (see Santangelo et al.,
2002). Predicted to be an outer membrane protein (See Song
et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1968"
/db_xref="EnsemblGenomes-Tr:CCP44737"
/db_xref="GOA:O53969"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O53969"
/protein_id="CCP44737.1"
/translation="MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSA
YFADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEVAIKTKG
LLGSKFLDVTPRGDGRLDSPIPIERTTSPYQLPDALGDLAATISGLHTERLSESLATL
AQTFADTPAHFRNAIHGVARLAQTLDERDNQLRSLLANAAKATGVLANRTDQIVGLVR
DTNVVLAQLRTQSAALDRIWANISAVAEQLRGFIAENRQQLRPALDKLNGVLAIVENR
KERVRQAIPLINTYVMSLGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPAT
LLPSQLTDPPTGQPGTPPLPMPYPRTGQGGEPRLTLPDAITGNPGDPRYPYRPEPPAP
PPGGPPPGPPAQQPGDQP"
gene 2212855..2214126
/gene="mce3D"
/locus_tag="Rv1969"
CDS 2212855..2214126
/codon_start=1
/transl_table=11
/gene="mce3D"
/locus_tag="Rv1969"
/product="Mce-family protein Mce3D"
/note="Rv1969, (MTV051.07), len: 423 aa. Mce3D; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530
aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); etc. Also
highly similar to others e.g. NP_302659.1|NC_002677
putative secreted protein from Mycobacterium leprae (531
aa); CAC12795.1|AL445327 putative secreted protein from
Streptomyces coelicolor (337 aa); etc. Contains a possible
N-terminal signal sequence or membrane anchor. The
transcription of this CDS seems negatively regulated by
the product of Rv1963c|mce3R (see Santangelo et al.,
2002). Predicted to be an outer membrane protein (See Song
et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1969"
/db_xref="EnsemblGenomes-Tr:CCP44738"
/db_xref="GOA:O53970"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O53970"
/protein_id="CCP44738.1"
/translation="MTTKLRRARSVLATALVLVAGVILAMRTADAAARTTVVAYFDNS
NGVFAGDDVLIRGVPVGKIVKIEPQPLRAKISFWFDRKYRVPADAAAAILSPQLVTGR
AIQLTPPYAGGPTMADGTVIPQERTVVPVEWDDLRAQLQRLTALLQPTRPGGVSTLGA
LINTAADNLRGQGATIRDTIIKLSQAISALGDHSKDIFSTVTNLSTLVTALHDSADLL
ERLNHNLAAVTSLLADGPDKIGQAAEDLNAVVADVGSFAAEHREAIGTASDKLASITT
ALVDSLDDIKQTLHISPTVLQNFNNIFEPANGALTGALAGNNMANPIAFLCGAIQAAS
RLGGEQAAKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWLRPDYVAP
VADTPPDPAAAVTVDPATGLRGMMMPPGGGS"
gene 2214123..2215256
/gene="lprM"
/gene_synonym="mce3E"
/locus_tag="Rv1970"
CDS 2214123..2215256
/codon_start=1
/transl_table=11
/gene="lprM"
/gene_synonym="mce3E"
/locus_tag="Rv1970"
/product="Possible Mce-family lipoprotein LprM (Mce-family
lipoprotein Mce3E)"
/note="Rv1970, (MTV051.08), len: 377 aa. Possible lprM
(alternate gene name: mce3E), lipoprotein which belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E
(390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa);
etc. Also highly similar to others e.g.
NP_302660.1|NC_002677 putative lipoprotein from
Mycobacterium leprae (392 aa); CAC12794.1|AL445327
putative secreted protein from Streptomyces coelicolor
(413 aa); etc. Contains possible N-terminal signal
sequence or membrane anchor and PS00013 Prokaryotic
membrane lipoprotein lipid attachment site. The
transcription of this CDS seems negatively regulated by
the product of Rv1963c|mce3R (see Santangelo et al.,
2002)."
/db_xref="EnsemblGenomes-Gn:Rv1970"
/db_xref="EnsemblGenomes-Tr:CCP44739"
/db_xref="GOA:O53971"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O53971"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP44739.1"
/translation="MRIGLTLVMIAAVVASCGWRGLNSLPLPGTQGNGPGSFAVQAQL
PDVNNIQPNSRVRVADVTVGHVTKIERQGWHALVTMRLDGDVDLPANATAKIGTTSLL
GSYHIELAPPKGEARQGKLRDGSLIALSHGSAYPSTEQTLAALSLVLNGGGLGQVQDI
TEALSTAFAGREHDLRGLIGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFD
RALATIPDALAVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLES
LANSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLLTGTRWE
CHLTQLELQWGRTIGQFPSPCTAGYRGTPGNPLTIAYRWDQGP"
gene 2215257..2216570
/gene="mce3F"
/locus_tag="Rv1971"
CDS 2215257..2216570
/codon_start=1
/transl_table=11
/gene="mce3F"
/locus_tag="Rv1971"
/product="Mce-family protein Mce3F"
/note="Rv1971, (MTV051.09), len: 437 aa. Mce3F; belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), similar to Mycobacterium
tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515
aa), O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); etc. Also
highly similar to others e.g. NP_302661.1|NC_002677
putative secreted protein from Mycobacterium leprae (516
aa); CAC12793.1|AL445327 putative secreted protein from
Streptomyces coelicolor (433 aa); etc. Contains a possible
N-terminal signal sequence or membrane anchor. The
transcription of this CDS seems negatively regulated by
the product of Rv1963c|mce3R (see Santangelo et al.,
2002). Predicted to be an outer membrane protein (See Song
et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1971"
/db_xref="EnsemblGenomes-Tr:CCP44740"
/db_xref="GOA:O53972"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:O53972"
/protein_id="CCP44740.1"
/translation="MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYT
VTMELVEAGGLYRTGNVTYRGFEVGRVAAVRLTDTGVQAVLALKSGIDIPSDLKAEVH
SHTAIGETYVELLPRNAASPPLKNGDVIALADTSVPPDINDLLSAANTALEAIPHENL
QTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDPLVALIDRAGPVLDSQTHTSD
AIAAWAAQLAAVTGQLQTHDSAVGDLIDRGGPALGETRQLLERLQPTVPILLANLVSV
GQVALTYHNDIEQLLVVFPMAIAAEQAGILANLNTKQAYRGQYLSFNLNLNLPPPCTT
GFLPAQQRRIPTFEDYPDRPAGDLYCRVPQDSPFNVRGARNIPCETVPGKRAPTVKLC
ESDAPYLPLNDGYNWKGDPNATVPGLGSGQDIPQTWQTMLLPPGS"
gene 2216592..2217167
/locus_tag="Rv1972"
CDS 2216592..2217167
/codon_start=1
/transl_table=11
/locus_tag="Rv1972"
/product="Probable conserved Mce associated membrane
protein"
/note="Rv1972, (MTV051.10), len: 191 aa. Probable
conserved Mce-associated membrane protein. Probably part
of mce3 operon. Similar to several Mycobacterium
tuberculosis proteins e.g. Rv1363c|Z75555|MTCY02B10.27C
(261 aa), FASTA scores: opt: 342, E(): 1.2e-15, (31.8%
identity in 195 aa overlap); Rv1362c, Rv0177 (near Mce
operon 1), etc. Has hydrophobic stretch at aa 20-40."
/db_xref="EnsemblGenomes-Gn:Rv1972"
/db_xref="EnsemblGenomes-Tr:CCP44741"
/db_xref="UniProtKB/TrEMBL:O53973"
/protein_id="CCP44741.1"
/translation="MSVAVDSDAEDDAVSEIAEAAGVSPAPAKPSMSAPRRMLLFGLV
VVVALAVLLCCWGFRVQRARHAQDQRGHFLQAARQCALNLTTIDWRNAEADVRRILDG
ATGEFYNDFAQRSQPFVEVLRHAKASTVGTITEAGLQTQTADTAQALVAVSVQTSNAG
EADPVPRAWRMRITVQRVGDRVKVSDVGFVP"
gene 2217164..2217646
/locus_tag="Rv1973"
CDS 2217164..2217646
/codon_start=1
/transl_table=11
/locus_tag="Rv1973"
/product="Possible conserved Mce associated membrane
protein"
/note="Rv1973, (MTV051.11), len: 160 aa. Possible
conserved Mce-associated membrane protein. Probably part
of mce3 operon. Similar to several other proteins from
Mycobacterium tuberculosis e.g.
Rv1362c|Z75555|MTCY02B10.26C (220 aa), FASTA scores: opt:
378, E(): 2.8e-19, (50.0% identity in 128 aa overlap);
Rv1363c; Rv0177 (near Mce operon 1); etc. Contains
possible N-terminal signal sequence or membrane anchor.
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1973"
/db_xref="EnsemblGenomes-Tr:CCP44742"
/db_xref="GOA:P9WJ77"
/db_xref="UniProtKB/Swiss-Prot:P9WJ77"
/protein_id="CCP44742.1"
/translation="MSWSRVIAYGLLPGLALALTCGAGLLKWQDGAVRDAAVARAESV
RAATDGTTALLSYRPDTVQHDLESARSRLTGTFLDAYTQLTHDVVIPGAQQKQISAVA
TVAAAASVSTSADRAVVLLFVNQTITVGKDAPTTAASSVRVTLDNINGRWLISQFEPI
"
gene 2217659..2218036
/locus_tag="Rv1974"
CDS 2217659..2218036
/codon_start=1
/transl_table=11
/locus_tag="Rv1974"
/product="Probable conserved membrane protein"
/note="Rv1974, (MTV051.12), len: 125 aa. Probable
conserved membrane protein, weakly similar to other
Mycobacterium tuberculosis proteins e.g.
Rv1271c|Z77137|MTCY50.11 (113 aa), FASTA scores: opt: 98,
E(): 1.4, (24.5% identity in 110 aa overlap); Rv1804c;
Rv1690. Has possible signal peptide or transmembrane
stretch from aa 12-30. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1974"
/db_xref="EnsemblGenomes-Tr:CCP44743"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/TrEMBL:O53975"
/protein_id="CCP44743.1"
/translation="MQRQSLMPQQTLAAGVFVGALLCGVVTAAVPPHARADVVAYLVN
VTVRPGYNFANADAALSYGHGLCEKVSRGRPYAQIIADVKADFDTRDQYQASYLLSQA
VNELCPALIWQLRNSAVDNRRSG"
gene 2218052..2218717
/locus_tag="Rv1975"
CDS 2218052..2218717
/codon_start=1
/transl_table=11
/locus_tag="Rv1975"
/product="Conserved hypothetical protein"
/note="Rv1975, (MTV051.13), len: 221 aa. Conserved
hypothetical protein, showing some similarity to AJ251435
hypothetical protein from Mycobacterium avium subsp.
paratuberculosis (193 aa). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1975"
/db_xref="EnsemblGenomes-Tr:CCP44744"
/db_xref="InterPro:IPR014044"
/db_xref="InterPro:IPR035940"
/db_xref="UniProtKB/TrEMBL:O53976"
/protein_id="CCP44744.1"
/translation="MSRRASATCALSATTAVAIMAAPAARADDKRLNDGVVANVYTVQ
RQAGCTNDVTINPQLQLAAQWHTLDLLNNRHLNDDTGSDGSTPQDRAHAAGFRGKVAE
TVAINPAVAISGIELINQWYYNPAFFAIMSDCANTQIGVWSENSPDRTVVVAVYGQPD
RPSAMPPRGAVTGPPSPVAAQENVPIDPSPDYDASDEIEYGINWLPWILRGVYPPPAM
PPQ"
gene complement(2218844..2219251)
/locus_tag="Rv1976c"
CDS complement(2218844..2219251)
/codon_start=1
/transl_table=11
/locus_tag="Rv1976c"
/product="Conserved hypothetical protein"
/note="Rv1976c, (MTV051.14), len: 135 aa. Conserved
hypothetical protein, similar to SC1C3.03c|AL023702
hypothetical protein from Streptomyces coelicolor (125
aa),FASTA score: opt: 223, E(): 3.3e-08, (39.6% identity
in 111 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1976c"
/db_xref="EnsemblGenomes-Tr:CCP44745"
/db_xref="InterPro:IPR010298"
/db_xref="UniProtKB/TrEMBL:O53977"
/protein_id="CCP44745.1"
/translation="MRWIVDGMNVIGSRPDGWWRDRHRAMVMLVERLEGWAITKARGD
DVTVVFERPPSTAIPSSVVEVAHAPKAAANSADDEIVRLVRSGAQPQEIRVVTSDKAL
TDRVRDLGAAVYPAERFRDLIDPRGSNAARRTQ"
gene 2219754..2220800
/locus_tag="Rv1977"
CDS 2219754..2220800
/codon_start=1
/transl_table=11
/locus_tag="Rv1977"
/product="Conserved protein"
/note="Rv1977, (MTV051.15), len: 348 aa. Conserved
protein,similar to SCC123.20|AL136518 hypothetical protein
from Streptomyces coelicolor (402 aa), blastp scores:
Score = 311 bits (789), Expect = 5e-84 Identities =
156/316 (49%),Positives = 212/316 (66%); and
PCC6803|D90907_31 Synechocystis sp. (303 aa), FASTA
scores: opt: 533, E(): 4.7e- 29, (38.5% identity in 275 aa
overlap). Contains PS00142 Neutral zinc metallopeptidases,
zinc-binding region signature. Alternative nucleotide at
position 2219929 (T->C; L59P) has been observed."
/db_xref="EnsemblGenomes-Gn:Rv1977"
/db_xref="EnsemblGenomes-Tr:CCP44746"
/db_xref="GOA:O53978"
/db_xref="InterPro:IPR001915"
/db_xref="UniProtKB/TrEMBL:O53978"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44746.1"
/translation="MSQTPATTRKTFPEISSRAWEHPADRTALSALRRLKGFDQILKL
MSGMLRERQHRLLYLASAARVGPRQFADLDALLDECVDVLDASAKPELYVMQSPIADA
FTIGMGKPFTVITSGLYDLVTHDEMRFVMGHELGHALSGHAVYRTMMMHLLRLARSFG
VLPVGGWALRAIVAALLEWQRKSELSGDRAGLLCAQDLDTALRVEMKLAGGCRLDKLD
SEAFLAQAREYETSGDMRDGVLKLLNLELQTHPFSVLRAAALTHWVDTGGYAKVIAGE
YPRRADDGNAKFADDLGAAARYYRDGFDQSNDPLIKGIRDGFGGIVEGVGRAASNAAD
SLGRKITEWRQPSK"
gene 2220908..2221756
/locus_tag="Rv1978"
CDS 2220908..2221756
/codon_start=1
/transl_table=11
/locus_tag="Rv1978"
/product="Conserved protein"
/note="Rv1978, (MTV051.16), len: 282 aa. Conserved
protein,similar to several hypothetical proteins and
methyltransferases e.g. X86780|SHGCPIR.15
methyltransferase from S. hygroscopicus (211 aa), FASTA
scores: opt: 151,E(): 0.0072, (30.6% identity in 121 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1978"
/db_xref="EnsemblGenomes-Tr:CCP44747"
/db_xref="GOA:O53979"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:O53979"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44747.1"
/translation="MGEANIREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVPDE
VKQKIIGVLDRVGTLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILELHPT
ATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYDLAVFALAFHHLPP
TVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVLLLPLHLLLLPWSSMRSSMHDGF
ISALRAYSPSALQTLARAADPGMQVEILPAPTRLFPPSLAVVFSRSSSAPTESSECSA
DRQPGE"
gene complement(2221719..2223164)
/locus_tag="Rv1979c"
CDS complement(2221719..2223164)
/codon_start=1
/transl_table=11
/locus_tag="Rv1979c"
/product="Possible conserved permease"
/note="Rv1979c, (MTCY39.40-MTV051.17c), len: 481 aa.
Possible permease, APC family possibly involved in
transport of amino acid, showing some similarity to other
permeases. Also similar to MTCY39.19 from Mycobacterium
tuberculosis (28.2% identity in 277 aa overlap). Contains
PS00599 Aminotransferases class-II pyridoxal-phosphate
attachment site. Nucleotide position 2221796 in the genome
sequence has been corrected, C:T resulting in V457I."
/db_xref="EnsemblGenomes-Gn:Rv1979c"
/db_xref="EnsemblGenomes-Tr:CCP44748"
/db_xref="GOA:P9WQM5"
/db_xref="InterPro:IPR002293"
/db_xref="UniProtKB/Swiss-Prot:P9WQM5"
/inference="protein motif:PROSITE:PS00599"
/protein_id="CCP44748.1"
/translation="MVGPRTRGYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIGLAG
PFAPMAYVLAGIFAGVVAIVFATAARYVRTNGASYAYTTAAFGRRIGIYVGVTHAITA
SIAWGVLASFFVSTLLRVAFPDKAWADAEQLFSVKTLTFLGFIGVLLAINLFGNRAIK
WANGTSTVGKAFALSAFIVGGLWIITTQHVNNYATAWSAYSATPYSLLGVAEIGKGTF
SSMALATIVALYAFTGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAML
LGSNKIAASDDTVKLAAAIGNATFRTIIVVGALISMFGINVAASFGAPRLWTALADSG
VLPTRLSRKNQYDVPMVSFAITASLALAFPLALRFDNLHLTGLAVIARFVQFIIVPIA
LIALARSQAVEHAAVRRNAFTDKVLPLVAIVVSVGLAVSYDYRCIFLVRGGPNYFSIA
LIVITFIVVPAMAYLHYYRIIRRVGDRPSTR"
gene complement(2223343..2224029)
/gene="mpt64"
/gene_synonym="mpb64"
/locus_tag="Rv1980c"
CDS complement(2223343..2224029)
/codon_start=1
/transl_table=11
/gene="mpt64"
/gene_synonym="mpb64"
/locus_tag="Rv1980c"
/product="Immunogenic protein Mpt64 (antigen Mpt64/MPB64)"
/note="Rv1980c, (MT2032, MTCY39.39), len: 228 aa. Mpt64
(alternate gene name: mpb64), immunogenic protein
(alternate gene name: mpb64) (see citations
below),identical to MPT64|MPB64 from Mycobacterium bovis
(228 aa). Similar to Rv3036c|MTV012.51c from Mycobacterium
tuberculosis. Exported protein containing a N-terminal
signal sequence: see notes below about proteomics.
Predicted possible vaccine candidate (See Zvi et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv1980c"
/db_xref="EnsemblGenomes-Tr:CCP44749"
/db_xref="GOA:P9WIN9"
/db_xref="InterPro:IPR021729"
/db_xref="InterPro:IPR037126"
/db_xref="PDB:2HHI"
/db_xref="UniProtKB/Swiss-Prot:P9WIN9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44749.1"
/translation="MRIKIFMLVTAVVLLCCSGVATAAPKTYCEELKGTDTGQACQIQ
MSDPAYNINISLPSYYPDQKSLENYIAQTRDKFLSAATSSTPREAPYELNITSATYQS
AIPPRGTQAVVLKVYQNAGGTHPTTTYKAFDWDQAYRKPITYDTLWQADTDPLPVVFP
IVQGELSKQTGQQVSIAPNAGLDPVNYQNFAVTNDGVIFFFNPGELLPEAAGPTQVLV
PRSAIDSMLA"
gene complement(2224220..2225188)
/gene="nrdF1"
/gene_synonym="nrdF"
/locus_tag="Rv1981c"
CDS complement(2224220..2225188)
/codon_start=1
/transl_table=11
/gene="nrdF1"
/gene_synonym="nrdF"
/locus_tag="Rv1981c"
/product="Ribonucleoside-diphosphate reductase (beta
chain) NrdF1 (ribonucleotide reductase small subunit) (R2F
protein)"
/note="Rv1981c, (MTCY39.38), len: 322 aa.
NrdF1,ribonucleoside-diphosphate reductase, beta chain
(see citation below), highly similar to others e.g.
RIR4_SALTY|P17424 ribonucleoside-diphosphate reductase
(319 aa), FASTA scores: opt: 1402, E(): 0, (66.0% identity
in 315 aa overlap); etc. Also similar to
Rv3048c|MTV012.63c from Mycobacterium tuberculosis.
Contains PS00368 Ribonucleotide reductase small subunit
signature. Belongs to the ribonucleoside diphosphate
reductase small chain family. Cofactor: binds 2 iron ions
(by similarity). Note that previously known as nrdF."
/db_xref="EnsemblGenomes-Gn:Rv1981c"
/db_xref="EnsemblGenomes-Tr:CCP44750"
/db_xref="GOA:P9WH73"
/db_xref="InterPro:IPR000358"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012348"
/db_xref="InterPro:IPR026494"
/db_xref="InterPro:IPR030475"
/db_xref="InterPro:IPR033909"
/db_xref="UniProtKB/Swiss-Prot:P9WH73"
/inference="protein motif:PROSITE:PS00368"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44750.1"
/translation="MTGKLVERVHAINWNRLLDAKDLQVWERLTGNFWLPEKIPLSND
LASWQTLSSTEQQTTIRVFTGLTLLDTAQATVGAVAMIDDAVTPHEEAVLTNMAFMES
VHAKSYSSIFSTLCSTKQIDDAFDWSEQNPYLQRKAQIIVDYYRGDDALKRKASSVML
ESFLFYSGFYLPMYWSSRGKLTNTADLIRLIIRDEAVHGYYIGYKCQRGLADLTDAER
ADHREYTCELLHTLYANEIDYAHDLYDELGWTDDVLPYMRYNANKALANLGYQPAFDR
DTCQVNPAVRAALDPGAGENHDFFSGSGSSYVMGTHQPTTDTDWDF"
gene complement(2225413..2225832)
/gene="vapC36"
/locus_tag="Rv1982c"
CDS complement(2225413..2225832)
/codon_start=1
/transl_table=11
/gene="vapC36"
/locus_tag="Rv1982c"
/product="Possible toxin VapC36. Contains PIN domain."
/note="Rv1982c, (MTCY39.37), len: 139 aa. Possible
vapC36,toxin, part of toxin-antitoxin (TA) operon with
Rv1982A,contains PIN domain, see Arcus et al. 2005.
belongs to the UPF0110 family. Similar to
Rv0624|Z92772|MTY20H10.05 from Mycobacterium tuberculosis
(131 aa), FASTA scores: opt: 288, E(): 4.1e-14, (40.2%
identity in 127 aa overlap); also similar to Rv0624,
Rv2759c, and Rv0609"
/db_xref="EnsemblGenomes-Gn:Rv1982c"
/db_xref="EnsemblGenomes-Tr:CCP44751"
/db_xref="GOA:P9WF65"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF65"
/protein_id="CCP44751.1"
/translation="MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLI
VLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAATQRAFLRYGKGRHRAALNFGDCM
TYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA"
gene complement(2225841..2226101)
/gene="vapB36"
/locus_tag="Rv1982A"
CDS complement(2225841..2226101)
/codon_start=1
/transl_table=11
/gene="vapB36"
/locus_tag="Rv1982A"
/product="Possible antitoxin VapB36"
/note="Rv1982A, len: 86 aa. Possible vapB36,
antitoxin,part of toxin-antitoxin (TA) operon with
Rv1982c, see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis e.g. Rv0623, Rv2760c, Rv0608"
/db_xref="EnsemblGenomes-Gn:Rv1982A"
/db_xref="EnsemblGenomes-Tr:CCP44752"
/db_xref="InterPro:IPR011660"
/db_xref="UniProtKB/Swiss-Prot:P9WJ29"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44752.1"
/translation="MALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRA
GDREAQLLDILRTEIWPLLADRSPITKLEREQILGYDPATGV"
gene 2226244..2227920
/gene="PE_PGRS35"
/locus_tag="Rv1983"
CDS 2226244..2227920
/codon_start=1
/transl_table=11
/gene="PE_PGRS35"
/locus_tag="Rv1983"
/product="PE-PGRS family protein PE_PGRS35"
/note="Rv1983, (MTCY39.36c), len: 558 aa. PE_PGRS35,
Member of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan & Delogu
2002). Similar to other PE proteins e.g. Rv0977, etc.
Contains PS00141 Eukaryotic and viral aspartyl proteases
active site."
/db_xref="EnsemblGenomes-Gn:Rv1983"
/db_xref="EnsemblGenomes-Tr:CCP44753"
/db_xref="GOA:P9WIF1"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR021109"
/db_xref="UniProtKB/Swiss-Prot:P9WIF1"
/inference="protein motif:PROSITE:PS00141"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44753.1"
/translation="MSFLVVVPEFLTSAAADVENIGSTLRAANAAAAASTTALAAAGA
DEVSAAVAALFARFGQEYQAVSAQASAFHQQFVQTLNSASGSYAAAEATIASQLQTAQ
HDLLGAVNAPTETLLGRPLIGDGAPGTATSPNGGAGGLLYGNGGNGYSATASGVGGGA
GGSAGLIGNGGAGGAGGPNAPGGAGGNGGWLLGNGGIGGPGGASSIPGMSGGAGGTGG
AAGLLGWGANGGAGGLGDGVGVDRGTGGAGGRGGLLYGGYGVSGPGGDGRTVPLEIIH
VTEPTVHANVNGGPTSTILVDTGSAGLVVSPEDVGGILGVLHMGLPTGLSISGYSGGL
YYIFATYTTTVDFGNGIVTAPTAVNVVLLSIPTSPFAISTYFSALLADPTTTPFEAYF
GAVGVDGVLGVGPNAVGPGPSIPTMALPGDLNQGVLIDAPAGELVFGPNPLPAPNVEV
VGSPITTLYVKIDGGTPIPVPSIIDSGGVTGTIPSYVIGSGTLPANTNIEVYTSPGGD
RLYAFNTNDYRPTVISSGLMNTGFLPFRFQPVYIDYSPSGIGTTVFDHPA"
gene complement(2227908..2228561)
/gene="cfp21"
/gene_synonym="clp1"
/gene_synonym="culp1"
/locus_tag="Rv1984c"
CDS complement(2227908..2228561)
/codon_start=1
/transl_table=11
/gene="cfp21"
/gene_synonym="clp1"
/gene_synonym="culp1"
/locus_tag="Rv1984c"
/product="Probable cutinase precursor CFP21"
/note="Rv1984c, (MTCY39.35), len: 217 aa. Cfp21, probable
cutinase precursor with N-terminal signal sequence,
similar to P41744|CUTI_ALTBR cutinase precursor from
Alternaria brassicicola (209 aa), FASTA scores: opt: 283,
E(): 2.2e-11, (32.6% identity in 193 aa overlap). Also
similar to Mycobacterium tuberculosis proteins e.g.
Rv3452, Rv3451,Rv2301, Rv1758, Rv3724. Belongs to the
cutinase family."
/db_xref="EnsemblGenomes-Gn:Rv1984c"
/db_xref="EnsemblGenomes-Tr:CCP44754"
/db_xref="GOA:P9WP43"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR011150"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WP43"
/inference="protein motif:PROSITE:PS00155"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44754.1"
/translation="MTPRSLVRIVGVVVATTLALVSAPAGGRAAHADPCSDIAVVFAR
GTHQASGLGDVGEAFVDSLTSQVGGRSIGVYAVNYPASDDYRASASNGSDDASAHIQR
TVASCPNTRIVLGGYSQGATVIDLSTSAMPPAVADHVAAVALFGEPSSGFSSMLWGGG
SLPTIGPLYSSKTINLCAPDDPICTGGGNIMAHVSYVQSGMTSQAATFAANRLDHAG"
gene complement(2228991..2229902)
/locus_tag="Rv1985c"
CDS complement(2228991..2229902)
/codon_start=1
/transl_table=11
/locus_tag="Rv1985c"
/product="Probable transcriptional regulatory protein
(probably LysR-family)"
/note="Rv1985c, (MTCY39.34), len: 303 aa. Probable
transcriptional regulatory protein, LysR family member.
Similar to many regulatory proteins, especially
ICIA_ECOLI|P24194 chromosome initiation inhibitor from
Escherichia coli (297 aa), FASTA scores: opt: 520, E():
1.1e-28, (35.8% identity in 285 aa overlap); and
P94632|LYSG_CORGL lysine export regulator protein (290
aa),FASTA scores: opt: 705, E(): 0, (42.7% identity in 288
aa overlap); etc. Contains PS00044 Bacterial regulatory
proteins, lysR family signature. Also contains
helix-turn-helix motif at aa 22-43,(+5.52 SD). Belongs to
the LysR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv1985c"
/db_xref="EnsemblGenomes-Tr:CCP44755"
/db_xref="GOA:P9WMF5"
/db_xref="InterPro:IPR000847"
/db_xref="InterPro:IPR005119"
/db_xref="InterPro:IPR017685"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:3ISP"
/db_xref="UniProtKB/Swiss-Prot:P9WMF5"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44755.1"
/translation="MVDPQLDGPQLAALAAVVELGSFDAAAERLHVTPSAVSQRIKSL
EQQVGQVLVVREKPCRATTAGIPLLRLAAQTALLESEALAEMGGNASLKRTRITIAVN
ADSMATWFSAVFDGLGDVLLDVRIEDQDHSARLLREGVAMGAVTTERNPVPGCRVHPL
GEMRYLPVASRPFVQRHLSDGFTAAAAAKAPSLAWNRDDGLQDMLVRKAFRRAITRPT
HFVPTTEGFTAAARAGLGWGMFPEKLAASPLADGSFVRVCDIHLDVPLYWQCWKLDSP
IIARITDTVRAAASGLYRGQQRRRRPG"
gene 2230011..2230610
/locus_tag="Rv1986"
CDS 2230011..2230610
/codon_start=1
/transl_table=11
/locus_tag="Rv1986"
/product="Probable conserved integral membrane protein"
/note="Rv1986, (MTCY39.33c), len: 199 aa. Probable
conserved integral membrane protein, LysE family possibly
involved in transport of Lysine, similar to
P11667|YGGA_ECOLI hypothetical 23.2 kDa protein in sbm-fba
intergenic region (211 aa), FASTA scores: opt: 379, E():
1.5e-19, (37.3% identity in 185 aa overlap); and
Q11154|Rv0488 hypothetical 20.9 kDa protein from M.
tuberculosis (201 aa), FASTA scores: opt: 784, E():
0,(63.4% identity in 186 aa overlap). Belongs to the
LYSE/YGGA family."
/db_xref="EnsemblGenomes-Gn:Rv1986"
/db_xref="EnsemblGenomes-Tr:CCP44756"
/db_xref="GOA:P9WK31"
/db_xref="InterPro:IPR001123"
/db_xref="InterPro:IPR004777"
/db_xref="UniProtKB/Swiss-Prot:P9WK31"
/protein_id="CCP44756.1"
/translation="MNSPLVVGFLACFTLIAAIGAQNAFVLRQGIQREHVLPVVALCT
VSDIVLIAAGIAGFGALIGAHPRALNVVKFGGAAFLIGYGLLAARRAWRPVALIPSGA
TPVRLAEVLVTCAAFTFLNPHVYLDTVVLLGALANEHSDQRWLFGLGAVTASAVWFAT
LGFGAGRLRGLFTNPGSWRILDGLIAVMMVALGISLTVT"
gene 2231026..2231454
/locus_tag="Rv1987"
CDS 2231026..2231454
/codon_start=1
/transl_table=11
/locus_tag="Rv1987"
/product="Possible chitinase"
/note="Rv1987, (MTCY39.32c), len: 142 aa. Possible
chitinase, similar to several e.g. P36909|CHIT_STRLI
chitinase c precursor (619 aa) FASTA scores, opt: 324,
E(): 1.2e-14, (39.5% identity in 129 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1987"
/db_xref="EnsemblGenomes-Tr:CCP44757"
/db_xref="GOA:P9WLQ1"
/db_xref="InterPro:IPR001919"
/db_xref="InterPro:IPR008965"
/db_xref="InterPro:IPR012291"
/db_xref="UniProtKB/Swiss-Prot:P9WLQ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44757.1"
/translation="MAGLNIYVRRWRTALHATVSALIVAILGLAITPVASAATARATL
SVTSTWQTGFIARFTITNSSTAPLTDWKLEFDLPAGESVLHTWNSTVARSGTHYVLSP
ANWNRIIAPGGSATGGLRGGLTGSYSPPSSCLLNGQYPCT"
gene 2231680..2232219
/gene="erm(37)"
/locus_tag="Rv1988"
CDS 2231680..2232219
/codon_start=1
/transl_table=11
/gene="erm(37)"
/locus_tag="Rv1988"
/product="Probable 23S rRNA methyltransferase Erm(37)"
/note="Rv1988, (MTCY39.31c), len: 179 aa. Probable
erm(37),23S rRNA methyltransferase, similar to
ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370
aa), FASTA scores: opt: 259, E(): 2e-11, (35.1% identity
in 171 aa overlap); contains PS00092 N-6 Adenine-specific
DNA methylases signature. Also similar to Mycobacterium
tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1988"
/db_xref="EnsemblGenomes-Tr:CCP44758"
/db_xref="GOA:Q10838"
/db_xref="InterPro:IPR001737"
/db_xref="InterPro:IPR020598"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:Q10838"
/inference="protein motif:PROSITE:PS00092"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44758.1"
/translation="MSALGRSRRAWGWHRLHDEWAARVVSAAAVRPGELVFDIGAGEG
ALTAHLVRAGARVVAVELHPRRVGVLRERFPGITVVHADAASIRLPGRPFRVVANPPY
GISSRLLRTLLAPNSGLVAADLVLQRALVCKFASRNARRFTLTVGLMLPRRAFLPPPH
VDSAVLVVRRRKCGDWQGR"
gene complement(2232739..2233299)
/locus_tag="Rv1989c"
CDS complement(2232739..2233299)
/codon_start=1
/transl_table=11
/locus_tag="Rv1989c"
/product="Hypothetical protein"
/note="Rv1989c, (MTCY39.30), len: 186 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1989c"
/db_xref="EnsemblGenomes-Tr:CCP44759"
/db_xref="GOA:P9WLP9"
/db_xref="InterPro:IPR014914"
/db_xref="PDB:6FKG"
/db_xref="UniProtKB/Swiss-Prot:P9WLP9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44759.1"
/translation="MSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRF
GGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTTAEKMLEAAYRLHTIDVTDLAVL
DLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT"
gene complement(2233296..2233637)
/locus_tag="Rv1990c"
CDS complement(2233296..2233637)
/codon_start=1
/transl_table=11
/locus_tag="Rv1990c"
/product="Probable transcriptional regulatory protein"
/note="Rv1990c, (MTCY39.29), len: 113 aa. Probable
transcriptional regulatory protein, similar to
Mycobacterium tuberculosis Rv3188|AL021646|MTV014.32 (115
aa), FASTA scores: opt: 184, E(): 8.2e-07, (28.4% identity
in 109 aa overlap). Contains probable helix-turn-helix
motif at aa 20-44 (+4.22 SD). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv1990c"
/db_xref="EnsemblGenomes-Tr:CCP44760"
/db_xref="InterPro:IPR024467"
/db_xref="PDB:6FKG"
/db_xref="UniProtKB/Swiss-Prot:P9WLP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44760.1"
/translation="MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVV
PQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPNRLLEHRKPADLVRDGEYQRVLA
LIDAMAEGVFV"
gene complement(2233881..2234216)
/locus_tag="Rv1990A"
CDS complement(2233881..2234216)
/codon_start=1
/transl_table=11
/locus_tag="Rv1990A"
/product="Possible dehydrogenase (fragment)"
/note="Rv1990A, len: 111 aa. Possible dehydrogenase
(fragment), similar to N-terminal part of several
dehydrogenases and hypothetical proteins, e.g.
Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis
(272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45%
identity in 78 aa overlap), but lacks C-terminal part.
Maybe a pseudogene. Also similar to U17129|RSU17129_7
putative short-chain alcohol dehydrogenase from
Rhodococcus erythropolis (275 aa), FASTA scores: opt: 142,
E(): 0.018,(54.15% identity in 48 aa overlap). This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1990A"
/db_xref="EnsemblGenomes-Tr:CCP44761"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:L7N6A3"
/protein_id="CCP44761.1"
/translation="MGRLEGKVAFITGVARGQGRSHAVRLADGQARALGKVDVEACGA
LVGEVEVWGRDVRDDRRVFVESPADEFGACRRVARQGIRVVGLPVSQRELVEPEAGCA
ARRSAAGSQ"
gene complement(2234305..2234649)
/gene="mazF6"
/gene_synonym="mt3"
/locus_tag="Rv1991c"
CDS complement(2234305..2234649)
/codon_start=1
/transl_table=11
/gene="mazF6"
/gene_synonym="mt3"
/locus_tag="Rv1991c"
/product="Toxin MazF6"
/note="Rv1991c, (MTCY39.28), len: 114 aa. MazF6,
toxin,part of toxin-antitoxin (TA) operon with Rv1991A.
Some similarity to P13976|PEMK_ECOLI pemk protein (133
aa),FASTA scores: opt: 113, E(): 0.043, (29.2% identity in
113 aa overlap); and P96622|YDCE protein from Bacillus
subtilis (116 aa), FASTA scores: opt: 227, E(): 6.9e-09,
(37.4% identity in 115 aa overlap). Also similar to
Mycobacterium tuberculosis Rv2801c, and Rv0659c. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv1991c"
/db_xref="EnsemblGenomes-Tr:CCP44762"
/db_xref="GOA:P9WII3"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="PDB:5HK0"
/db_xref="PDB:5HK3"
/db_xref="PDB:5HKC"
/db_xref="UniProtKB/Swiss-Prot:P9WII3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44762.1"
/translation="MVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVI
AAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTAIVTLNKTDLTDRVGEVPASLMH
EVDRGLRRVLDL"
gene complement(2234643..2234891)
/gene="mazE6"
/locus_tag="Rv1991A"
CDS complement(2234643..2234891)
/codon_start=1
/transl_table=11
/gene="mazE6"
/locus_tag="Rv1991A"
/product="Antitoxin MazE6"
/note="Rv1991A, len: 82 aa. MazE6, antitoxin, part of
toxin-antitoxin (TA) operon with Rv1991c. Similar to ChpI
of L. interrogans, FASTA scores: opt: 134, E():
0.024,29.762% identity (65.476% similar) in 84 aa overlap.
Note that Pandey and Gerdes, 2005 predicts a different
N-terminus, adding 10 amino acids."
/db_xref="EnsemblGenomes-Gn:Rv1991A"
/db_xref="EnsemblGenomes-Tr:CCP44763"
/db_xref="GOA:P9WJ87"
/db_xref="InterPro:IPR002145"
/db_xref="InterPro:IPR010985"
/db_xref="UniProtKB/Swiss-Prot:P9WJ87"
/protein_id="CCP44763.1"
/translation="MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQ
LLTGQIDRALESIHGTDEAEALAVANAYRVLETMDDEW"
gene complement(2234991..2237306)
/gene="ctpG"
/gene_synonym="cmtA"
/locus_tag="Rv1992c"
CDS complement(2234991..2237306)
/codon_start=1
/transl_table=11
/gene="ctpG"
/gene_synonym="cmtA"
/locus_tag="Rv1992c"
/product="Probable metal cation transporter P-type ATPase
G CtpG"
/note="Rv1992c, (MTCY39.27), len: 771 aa. Probable
ctpG,metal cation-transporting P-type ATPase G
(transmembrane protein), similar to others, especially
cadmium-transporting ATPases, e.g. NP_244904.1|NC_002570
cadmium-transporting ATPase from Bacillus halodurans (707
aa); P30336|CADA_BACFI probable cadmium-transporting
ATPase from Bacillus firmus (723 aa); BAB47609.1|AB037671
cadmium resistance protein B from Staphylococcus aureus
(804 aa); 3121832|Q60048|CADA_LISMO probable
cadmium-transporting ATPase from Listeria monocytogenes
(707 aa); etc. Also similar to others from Mycobacterium
tuberculosis e.g. Rv0969|MTCY10D7.05c|ctpV putative cation
transporter P-type ATPase V (770 aa); Rv1469; Rv0092; etc.
Contains PS00435 Peroxidases proximal heme-ligand
signature and PS00154 E1-E2 ATPases phosphorylation site.
Belongs to the cation transport ATPases family (E1-E2
ATPases), subfamily IB."
/db_xref="EnsemblGenomes-Gn:Rv1992c"
/db_xref="EnsemblGenomes-Tr:CCP44764"
/db_xref="GOA:P9WPS7"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR027256"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPS7"
/inference="protein motif:PROSITE:PS00154"
/inference="protein motif:PROSITE:PS00435"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44764.1"
/translation="MTTVVDAEVQLTVVSDAAGRMRVQATGFQFDAGRAVAIEDTVGK
VAGVQAVHAYPRTASIVIWYSRAICDTAAILSAIIDAETVPAAAVPAYASRSASNRKA
GVVQKIIDWSTRTLSGVRRDVAAQPSGETSDACCDGEDNEDREPEQLWQVAKLRRAAF
SGVLLTASLVAAWAYPLWPVVLGLKALALAVGASTFVPSSLKRLAEGRVGVGTLMTIA
ALGAVALGELGEAATLAFLFSISEGLEEYATARTRRGLRALLSLVPDQATVLREGTET
IVASTELHVGDQMIVKPGERLATDGIIRAGRTALDVSAITGESVPVEVGPGDEVFAGS
INGLGVLQVGVTATAANNSLARIVHIVEAEQVRKGASQRLADCIARPLVPSIMIAAAL
IAGTGSVLGNPLVWIERALVVLVAAAPCALAIAVPVTVVASIGAASRLGVLIKGGAAL
ETLGTIRAVALDKTGTLTANRPVVIDVATTNGATREEVLAVAAALEARSEHPLAVAVL
AATQATTAASDVQAVPGAGLIGRLDGRVVRLGRPGWLDAAELADHVACMQQAGATAVL
VERDQQLLGAIAVRDELRPEAAEVVAGLRTGGYQVTMLTGDNHATAAALAAQAGIEQV
HAELRPEDKAHLVAQLRARQPTAMVGDGVNDAPALAAADLGIAMGAMGTDVAIETADV
ALMGQDLRHLPQALDHARRSRQIMVQNVGLSLSIITVLMPLALFGILGLAAVVLVHEF
TEVIVIANGVRAGRIKPLAGPPKTPDRTIPG"
gene complement(2237303..2237575)
/locus_tag="Rv1993c"
CDS complement(2237303..2237575)
/codon_start=1
/transl_table=11
/locus_tag="Rv1993c"
/product="Conserved protein"
/note="Rv1993c, (MTCY39.26), len: 90 aa. Conserved
protein,very similar to Rv3269|Z92771|MTCY71.09
hypothetical protein from Mycobacterium tuberculosis (93
aa), FASTA results: opt: 309, E(): 3.2e-16, (63.3%
identity in 79 aa overlap). Also similar to Rv0968 (98 aa)
(51.1% identity in 94 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1993c"
/db_xref="EnsemblGenomes-Tr:CCP44765"
/db_xref="GOA:P9WLP5"
/db_xref="InterPro:IPR009963"
/db_xref="UniProtKB/Swiss-Prot:P9WLP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44765.1"
/translation="MVTHELLVKAAGAVLTGLVGVSAYETLRKALGTAPIRRASVTVM
EWGLRGTRRAEAAAESARLTVADVVAEARGRIGEEAPLPAGARVDE"
gene complement(2237628..2237984)
/gene="cmtR"
/locus_tag="Rv1994c"
CDS complement(2237628..2237984)
/codon_start=1
/transl_table=11
/gene="cmtR"
/locus_tag="Rv1994c"
/product="Metal sensor transcriptional regulator CmtR
(ArsR-SmtB family)"
/note="Rv1994c, (MTCY39.25), len: 118 aa.
CmtR,transcriptional regulator (See Cavet et al., 2003).
Similar to MERR_STRLI|P30346 probable mercury resistance
operon repressor (125 aa), FASTA scores: opt: 199, E():
3e-08,(36.3% identity in 102 aa overlap). Note that primer
extension analysis revealed two transcriptional start
sites (See Chauhan et al., 2009)."
/db_xref="EnsemblGenomes-Gn:Rv1994c"
/db_xref="EnsemblGenomes-Tr:CCP44766"
/db_xref="GOA:P9WMI9"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:2JSC"
/db_xref="UniProtKB/Swiss-Prot:P9WMI9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44766.1"
/translation="MLTCEMRESALARLGRALADPTRCRILVALLDGVCYPGQLAAHL
GLTRSNVSNHLSCLRGCGLVVATYEGRQVRYALADSHLARALGELVQVVLAVDTDQPC
VAERAASGEAVEMTGS"
gene 2238141..2238908
/locus_tag="Rv1995"
CDS 2238141..2238908
/codon_start=1
/transl_table=11
/locus_tag="Rv1995"
/product="Unknown protein"
/note="Rv1995, (MTCY39.24c), len: 255 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv1995"
/db_xref="EnsemblGenomes-Tr:CCP44767"
/db_xref="GOA:P9WLP3"
/db_xref="InterPro:IPR012312"
/db_xref="UniProtKB/Swiss-Prot:P9WLP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44767.1"
/translation="MVASGAATKGVTVMKQTPPAAVGRRHLLEISASAAGVIALSACS
GSPPEPGKGRPDTTPEQEVPVTAPEDLMREHGVLKRILLIYREGIRRLQADDQSPAPA
LNESAQIIRRFIEDYHGQLEEQYVFPKLEQAGKLTDITSVLRTQHQRGRVLTDRVLAA
TTAAAAFDQPARDTLAQDMAAYIRMFEPHEAREDTVVFPALRDVMSAVEFRDMAETFE
DEEHRRFGEAGFQSVVDKVADIEKSLGIYDLSQFTPS"
gene 2239004..2239957
/locus_tag="Rv1996"
CDS 2239004..2239957
/codon_start=1
/transl_table=11
/locus_tag="Rv1996"
/product="Universal stress protein family protein"
/note="Rv1996, (MTCY39.23c), len: 317 aa. Universal stress
protein family protein. Similar to several Mycobacterium
tuberculosis hypothetical proteins e.g.
Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scores: opt:
775,E(): 0, (50.3% identity in 316 aa overlap); Rv2026c
(294 aa) (47.9% identity in 311 aa overlap); and Rv2623,
etc. Also similar to SCJ1.30c|AL109962 hypothetical
protein from Streptomyces coelicolor (328 aa). Predicted
possible vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv1996"
/db_xref="EnsemblGenomes-Tr:CCP44768"
/db_xref="GOA:P9WLP1"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="UniProtKB/Swiss-Prot:P9WLP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44768.1"
/translation="MSAQQTNLGIVVGVDGSPCSHTAVEWAARDAQMRNVALRVVQVV
PPVITAPEGWAFEYSRFQEAQKREIVEHSYLVAQAHQIVEQAHKVALEASSSGRAAQI
TGEVLHGQIVPTLANISRQVAMVVLGYRGQGAVAGALLGSVSSSLVRHAHGPVAVIPE
EPRPARPPHAPVVVGIDGSPTSGLAAEIAFDEASRRGVDLVALHAWSDMGPLDFPRLN
WAPIEWRNLEDEQEKMLARRLSGWQDRYPDVVVHKVVVCDRPAPRLLELAQTAQLVVV
GSHGRGGFPGMHLGSVSRAVVNSGQAPVIVARIPQDPAVPA"
gene 2240159..2242876
/gene="ctpF"
/locus_tag="Rv1997"
CDS 2240159..2242876
/codon_start=1
/transl_table=11
/gene="ctpF"
/locus_tag="Rv1997"
/product="Probable metal cation transporter P-type ATPase
A CtpF"
/note="Rv1997, (MTCY39.22c, MTCY39.21c), len: 905 aa.
Probable ctpF, metal cation-transporting P-type ATPase F
(transmembrane protein), highly similar to others e.g.
NP_250120.1|NC_002516 probable cation-transporting P-type
ATPase from Pseudomonas aeruginosa (902 aa);
NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2
ATPase) from Synechocystis sp. strain PCC 6803 (905 aa);
NP_404093.1|NC_003143 putative cation-transporting P-type
ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3
cation-transporting ATPase pma1 from Synechocystis sp.
(915 aa), FASTA scores: opt: 2392, E(): 0, (46.5% identity
in 852 aa overlap); etc. Contains PS00154 E1-E2 ATPases
phosphorylation site. Belongs to the cation transport
ATPases family (E1-E2 ATPases), subfamily IB. Was
frame-shifted in original cosmid sequence."
/db_xref="EnsemblGenomes-Gn:Rv1997"
/db_xref="EnsemblGenomes-Tr:CCP44769"
/db_xref="GOA:P9WPS9"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR004014"
/db_xref="InterPro:IPR006068"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPS9"
/inference="protein motif:PROSITE:PS00154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44769.1"
/translation="MSASVSATTAHHGLPAHEVVLLLESDPYHGLSDGEAAQRLERFG
PNTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLKEFVDAAVIFGVVVINAIVG
FIQESKAEAALQGLRSMVHTHAKVVREGHEHTMPSEELVPGDLVLLAAGDKVPADLRL
VRQTGLSVNESALTGESTPVHKDEVALPEGTPVADRRNIAYSGTLVTAGHGAGIVVAT
GAETELGEIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRRQDAVE
TFTAAIALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETLGSTTVICADK
TGTLTENQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDAPVPVNANAALRWSLLAGA
CSNDAALVRDGTRWQIVGDPTEGAMLVVAAKAGFNPERLATTLPQVAAIPFSSERQYM
ATLHRDGTDHVVLAKGAVERMLDLCGTEMGADGALRPLDRATVLRATEMLTSRGLRVL
ATGMGAGAGTPDDFDENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAGIAVKMITG
DHAGTATAIATEVGLLDNTEPAAGSVLTGAELAALSADQYPEAVDTASVFARVSPEQK
LRLVQALQARGHVVAMTGDGVNDAPALRQANIGVAMGRGGTEVAKDAADMVLTDDDFA
TIEAAVEEGRGVFDNLTKFITWTLPTNLGEGLVILAAIAVGVALPILPTQILWINMTT
AIALGLMLAFEPKEAGIMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELD
NGAGLHEARTAALNLFVVVEAFYLFSCRSLTRSAWRLGMFANRWIILGVSAQAIAQFA
ITYLPAMNMVFDTAPIDIGVWVRIFAVATAITIVVATDTLLPRIRAQPP"
gene complement(2242945..2243721)
/locus_tag="Rv1998c"
CDS complement(2242945..2243721)
/codon_start=1
/transl_table=11
/locus_tag="Rv1998c"
/product="Conserved protein"
/note="Rv1998c, (MTCY39.20), len: 258 aa. Conserved
protein, showing some similarity with other hypothetical
proteins e.g. U82823|SEU82823.03 Saccharopolyspora
erythraea (266 aa), FASTA results: opt: 654, E(): 0,
(43.8% identity in 249 aa overlap); and AL034446|SC1A9.07
Streptomyces coelicolor (251 aa), FASTA scores: opt:
592,E(): 1.5e-31, (43.4% identity in 251 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv1998c"
/db_xref="EnsemblGenomes-Tr:CCP44770"
/db_xref="GOA:P9WLN9"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR039556"
/db_xref="InterPro:IPR040442"
/db_xref="UniProtKB/Swiss-Prot:P9WLN9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44770.1"
/translation="MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSS
SGGHPDGHRATRGANIALAAALAPLQCYVSVDIEDGYSDEPDAIADYVAQLSTAGINI
EDSSAEKLIDPALAAAKIVAIKQRNPEVFVNARVDTYWLRQHADTTSTIQRALRYVDA
GADGVFVPLANDPDELAELTRNIPCPVNTLPVPGLTIADLGELGVARVSTGSVPYSAG
LYAAAHAARAVSDGEQLPRSVPYAELQARLVDYENRTSTT"
gene complement(2243816..2245138)
/locus_tag="Rv1999c"
CDS complement(2243816..2245138)
/codon_start=1
/transl_table=11
/locus_tag="Rv1999c"
/product="Probable conserved integral membrane protein"
/note="Rv1999c, (MTCY39.19), len: 440 aa. Probable
conserved integral membrane protein, possibly transporter
of cationic amino acid, similar to many
transporters,especially amino acid transporters, e.g.
CAC08265.1|AL392146 putative amino acid transporter from
Streptomyces coelicolor (414 aa); P39277|YJEH_ECOLI
hypothetical 44.8 kDa protein from Escherichia coli (418
aa), FASTA scores, opt: 343, E(): 6.6e-15, (27.2% identity
in 408 aa overlap); etc. Also similar to Rv1979c from
Mycobacterium tuberculosis, FASTA score: (28.2% identity
in 277 aa overlap); Rv2127, Rv0346c, Rv0522, etc. Seems to
belong to the APC family."
/db_xref="EnsemblGenomes-Gn:Rv1999c"
/db_xref="EnsemblGenomes-Tr:CCP44771"
/db_xref="GOA:P9WQM3"
/db_xref="InterPro:IPR002293"
/db_xref="UniProtKB/Swiss-Prot:P9WQM3"
/protein_id="CCP44771.1"
/translation="MRRPLDPRDIPDELRRRLGLLDAVVIGLGSMIGAGIFAALAPAA
YAAGSGLLLGLAVAAVVAYCNAISSARLAARYPASGGTYVYGRMRLGDFWGYLAGWGF
VVGKTASCAAMALTVGFYVWPAQAHAVAVAVVVALTAVNYAGIQKSAWLTRSIVAVVL
VVLTAVVVAAYGSGAADPARLDIGVDAHVWGMLQAAGLLFFAFAGYARIATLGEEVRD
PARTIPRAIPLALGITLAVYALVAVAVIAVLGPQRLARAAAPLSEAMRVAGVNWLIPV
VQIGAAVAALGSLLALILGVSRTTLAMARDRHLPRWLAAVHPRFKVPFRAELVVGAVV
AALAATADIRGAIGFSSFGVLVYYAIANASALTLGLDEGRPRRLIPLVGLIGCVVLAF
ALPLSSVAAGAAVLGVGVAAYGVRRIITRRARQTDSGDTQRSGHPSAT"
gene 2245209..2246822
/locus_tag="Rv2000"
CDS 2245209..2246822
/codon_start=1
/transl_table=11
/locus_tag="Rv2000"
/product="Unknown protein"
/note="Rv2000, (MTCY39.18c), len: 537 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv2000"
/db_xref="EnsemblGenomes-Tr:CCP44772"
/db_xref="GOA:P9WLN7"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WLN7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44772.1"
/translation="MRPGFVGLGFGQWPVYVVRWPKLHLTPRQRKRVLHRRRLLTDRP
ISLSQIPIRTGGPMNDPWPRPTQGPAKTIETDYLVIGAGAMGMAFTDTLITESGARVV
MIDRACQPGGHWTTAYPFVRLHQPSAYYGVNSRALGNNTIDLVGWNQGLNELAPVGEI
CAYFDAVLQQQLLPTGRVDYFPMSEYLGDGRFRTLAGTEYVVTVNRRIVDATYLRAVV
PSMRPAPYSVAPGVDCVAPNELPKLGTRDRYVVVGAGKTGMDVCLWLLRNDVCPDKLT
WIMPRDSWLIDRATLQPGPTFVRQFRESYGATLEAIGAATSTDDLFDRLETAGTLLRI
DPSVRPSMYRCATVSHLELEQLRRIRDIVRMGHVQRIEPTTIVLDGGSVPATPTALYI
DCTADGAPQRPAKPVFDADHLTLQAVRGCQQVFSAAFIAHVEFAYEDDAVKNELCTPI
PHPDCDLDWMRLMHSDLGNFQRWLNDPDLTDWLSSARLNLLADLLPPLSHKPRVRERV
VSMFQKRLGTAGDQLAKLLDAATATTEQR"
gene 2246832..2247584
/locus_tag="Rv2001"
CDS 2246832..2247584
/codon_start=1
/transl_table=11
/locus_tag="Rv2001"
/product="Conserved hypothetical protein"
/note="Rv2001, (MTCY39.17c), len: 250 aa. Conserved
hypothetical protein. Similar to Mycobacterium
tuberculosis Rv0466."
/db_xref="EnsemblGenomes-Gn:Rv2001"
/db_xref="EnsemblGenomes-Tr:CCP44773"
/db_xref="GOA:P9WLN5"
/db_xref="InterPro:IPR002864"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/Swiss-Prot:P9WLN5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44773.1"
/translation="MHHNRDVDLALVERPSSGYVYTTGWRLATTDIDEHQQLRLDGVA
RYIQEVGAEHLADAQLAEVHPHWIVLRTVIDVINPIELPSDITFHRWCAALSTRWCSM
RVQLQGSAGGRIETEGFWICVNKDTLTPSRLTDDCIARFGSTTENHRLKWRPWLTGPN
IDGTETPFPLRRTDIDPFEHVNNTIYWHGVHEILCQIPTLTAPYRAVLEYRSPIKSGE
PLTIRYEQHDDVVRMHFVVGDDVRAAALLRRL"
gene 2247660..2248442
/gene="fabG3"
/locus_tag="Rv2002"
CDS 2247660..2248442
/codon_start=1
/transl_table=11
/gene="fabG3"
/locus_tag="Rv2002"
/product="Possible 20-beta-hydroxysteroid dehydrogenase
FabG3 (cortisone reductase) ((R)-20-hydroxysteroid
dehydrogenase)"
/note="Rv2002, (MTCY39.16c), len: 260 aa.
FabG3,20-beta-hydroxysteroid dehydrogenase. Contains
PS00061 Short-chain alcohol dehydrogenase family
signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv2002"
/db_xref="EnsemblGenomes-Tr:CCP44774"
/db_xref="GOA:P9WGT1"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:1NFF"
/db_xref="PDB:1NFQ"
/db_xref="PDB:1NFR"
/db_xref="UniProtKB/Swiss-Prot:P9WGT1"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44774.1"
/translation="MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEG
KAVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYAL
TEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAV
RGLTKSTALELGPSGIRVNSIHPGLVKTPMTDWVPEDIFQTALGRAAEPVEVSNLVVY
LASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT"
gene complement(2248563..2249420)
/locus_tag="Rv2003c"
CDS complement(2248563..2249420)
/codon_start=1
/transl_table=11
/locus_tag="Rv2003c"
/product="Conserved hypothetical protein"
/note="Rv2003c, (MTCY39.14), len: 285 aa. Conserved
hypothetical protein."
/db_xref="EnsemblGenomes-Gn:Rv2003c"
/db_xref="EnsemblGenomes-Tr:CCP44775"
/db_xref="GOA:P9WJZ5"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WJZ5"
/protein_id="CCP44775.1"
/translation="MVKRSRATRLSPSIWSGWESPQCRSIRARLLLPRGRSRPPNADC
CWNQLAVTPDTRMPASSAAGRDAAAYDAWYDSPTGRPILATEVAALRPLIEVFAQPRL
EIGVGTGRFADLLGVRFGLDPSRDALMFARRRGVLVANAVGEAVPFVSRHFGAVLMAF
TLCFVTDPAAIFRETRRLLADGGGLVIGFLPRGTPWADLYALRAARGQPGYRDARFYT
AAELEQLLADSGFRVIARRCTLHQPPGLARYDIEAAHDGIQAGAGFVAISAVDQAHEP
KDDHPLESE"
gene complement(2249478..2250974)
/locus_tag="Rv2004c"
CDS complement(2249478..2250974)
/codon_start=1
/transl_table=11
/locus_tag="Rv2004c"
/product="Conserved protein"
/note="Rv2004c, (MTCY39.13), len: 498 aa. Conserved
protein. Contains PS00017 ATP/GTP-binding site motif A."
/db_xref="EnsemblGenomes-Gn:Rv2004c"
/db_xref="EnsemblGenomes-Tr:CCP44776"
/db_xref="GOA:P9WLN3"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WLN3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44776.1"
/translation="MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKP
VVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRD
KQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAEL
RHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGE
PALLDCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLR
DFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTG
KSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALR
KARLLLGSGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARA
GGNSDATAEIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI"
gene complement(2250996..2251883)
/locus_tag="Rv2005c"
CDS complement(2250996..2251883)
/codon_start=1
/transl_table=11
/locus_tag="Rv2005c"
/product="Universal stress protein family protein"
/note="Rv2005c, (MTCY39.12), len: 295 aa. Universal stress
protein family protein. Predicted possible vaccine
candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2005c"
/db_xref="EnsemblGenomes-Tr:CCP44777"
/db_xref="GOA:P9WLN1"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="UniProtKB/Swiss-Prot:P9WLN1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44777.1"
/translation="MSKPRKQHGVVVGVDGSLESDAAACWGATDAAMRNIPLTVVHVV
NADVATWPPMPYPETWGVWQEDEGRQIVANAVKLAKEAVGADRKLSVKSELVFSTPVP
TMVEISNEAEMVVLGSSGRGALARGLLGSVSSSLVRRAGCPVAVIHSDDAVIPDPQHA
PVLVGIDGSPVSELATAVAFDEASRRGVELIAVHAWSDVEVVELPGLDFSAVQQEAEL
SLAERLAGWQERYPDVPVSRVVVCDRPARKLVQKSASAQLVVVGSHGRGGLTGMLLGS
VSNAVLHAARVPVIVARQS"
gene 2252002..2255985
/gene="otsB1"
/gene_synonym="otsB"
/locus_tag="Rv2006"
CDS 2252002..2255985
/codon_start=1
/transl_table=11
/gene="otsB1"
/gene_synonym="otsB"
/locus_tag="Rv2006"
/product="Probable trehalose-6-phosphate phosphatase OtsB1
(trehalose-phosphatase) (TPP)"
/note="Rv2006, (MTCY39.11c), len: 1327 aa.
OtsB1,trehalose-6-phosphate phosphatase (see citations
below). Belongs to Glycosyl hydrolases family 65. Note
that previously known as otsB. Predicted possible vaccine
candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2006"
/db_xref="EnsemblGenomes-Tr:CCP44778"
/db_xref="GOA:P9WN15"
/db_xref="InterPro:IPR003337"
/db_xref="InterPro:IPR005194"
/db_xref="InterPro:IPR005195"
/db_xref="InterPro:IPR005196"
/db_xref="InterPro:IPR006379"
/db_xref="InterPro:IPR008928"
/db_xref="InterPro:IPR011013"
/db_xref="InterPro:IPR012341"
/db_xref="InterPro:IPR023198"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="InterPro:IPR037018"
/db_xref="UniProtKB/Swiss-Prot:P9WN15"
/inference="protein motif:PROSITE:PS00148"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44778.1"
/translation="MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWT
KFLDDYLTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDLTD
DTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSHRNYGHTLDAT
GLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANPGRCVVIDSCQTGLRAGRN
GGFALVIAVDAHGDAENLLSSGADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRL
LTGRRPAVFLDFDGTLSDIVERPEAATLVDGAAEALRALAAQCPVAVISGRDLADVRN
RVKVDGLWLAGSHGFELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEH
KRFAVAVHYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKALDW
IGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVRHNEHGDRRSAATFRL
ECPYTVCQFLSQLACDLQEAVQHDDPWTLVFHGYDPGQERLREALCAVGNGYLGSRGC
APESAESEAHYPGTYVAGVYNQLTDHIEGCTVDNESLVNLPNWLSLTFRIDGGAWFNV
DTVELLSYRQTFDLRRATLTRSLRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESE
NWSGTVDFRSLVDGGVHNTLVDRYRQLSSQHLTTAEIEVLADSVLLRTQTSQSGIAIA
VAARSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDAATL
TAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTEELRLVRLHLLHLLQT
ISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLSLRMPKVARSLLDYRYRRLPA
ARRAAHRAGHLGAMYPWQSGSDGSEVSQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNA
WHYYQVTGDRQYLVDCGAELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPG
NEYDGIDNNAYTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRR
MFVPFHDGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQAD
ALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSAVVHAWVLARA
NRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDLLQRCYSGLELRDDRLVLS
PQWPEALGPLEFPFVYRRHQLSLRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHT
IEVGCSR"
gene complement(2256084..2256428)
/gene="fdxA"
/locus_tag="Rv2007c"
CDS complement(2256084..2256428)
/codon_start=1
/transl_table=11
/gene="fdxA"
/locus_tag="Rv2007c"
/product="Ferredoxin FdxA"
/note="Rv2007c, (MTCY39.10), len: 114 aa. FdxA,
ferredoxin,similar to many e.g. FER_MYCSM P00215
ferredoxin,Mycobacterium smegmatis (106 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2007c"
/db_xref="EnsemblGenomes-Tr:CCP44779"
/db_xref="GOA:P9WNE7"
/db_xref="InterPro:IPR000813"
/db_xref="InterPro:IPR017896"
/db_xref="UniProtKB/Swiss-Prot:P9WNE7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44779.1"
/translation="MTYVIGSECVDVMDKSCVQECPVDCIYEGARMLYINPDECVDCG
ACKPACRVEAIYWEGDLPDDQHQHLGDNAAFFHQVLPGRVAPLGSPGGAAAVGPIGVD
TPLVAAIPVECP"
gene complement(2256617..2257942)
/locus_tag="Rv2008c"
CDS complement(2256617..2257942)
/codon_start=1
/transl_table=11
/locus_tag="Rv2008c"
/product="Conserved hypothetical protein"
/note="Rv2008c, (MTCY39.09), len: 441 aa. Conserved
hypothetical protein. Contains PS00017 ATP/GTP-binding
site motif A, PS00501 Signal peptidases I serine active
site. Also contains helix-turn-helix motif at aa 258-279."
/db_xref="EnsemblGenomes-Gn:Rv2008c"
/db_xref="EnsemblGenomes-Tr:CCP44780"
/db_xref="GOA:P9WLM9"
/db_xref="InterPro:IPR025420"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041682"
/db_xref="UniProtKB/Swiss-Prot:P9WLM9"
/inference="protein motif:PROSITE:PS00501"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44780.1"
/translation="MDEIESLIGLRPTPLTWPVVIAGDFLGVWDPPPSLPGAANHEIS
APTARISCMLIERRDAAARLRRALHRAPVVLLTGPRQAGKTTLSRLVGKSAPECTFDA
ENPVDATRLADPMLALSGLSGLITIDEAQRIPDLFPVLRVLVDRPVMPARFLILGSAS
PDLVGLASESLAGRVELVELSGLTVRDVGSSAADRLWLRGGLPPSFTARSNEDSAAWR
DGYITTFLERDLAQLGVRIPAATMRRAWTMLAHYHGQLFSGAELARSLDVAQTTARRY
LDALTDALVVRQLTPWFANIGKRQRRSPKIYIRDTGLLHRLLGIDDRLALERNPKLGA
SWEGFVLEQLAALLAPNPLYYWRTQQDAELDLYVELSGRPYGFEIKRTSTPSISRSMR
SALVDLQLARLAIVYPGEHRFPLSDTVVAVPADQILTTGSVDELLALLK"
gene 2258030..2258272
/gene="vapB15"
/locus_tag="Rv2009"
CDS 2258030..2258272
/codon_start=1
/transl_table=11
/gene="vapB15"
/locus_tag="Rv2009"
/product="Antitoxin VapB15"
/note="Rv2009, (MTCY39.08c), len: 80 aa. VapB15,
antitoxin,part of toxin-antitoxin (TA) operon with Rv2010
(See Arcus et al., 2005; Pandey and Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2009"
/db_xref="EnsemblGenomes-Tr:CCP44781"
/db_xref="GOA:P9WLM7"
/db_xref="InterPro:IPR019239"
/db_xref="PDB:4CHG"
/db_xref="UniProtKB/Swiss-Prot:P9WLM7"
/protein_id="CCP44781.1"
/translation="MYSGVVSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGE
PLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES"
gene 2258273..2258671
/gene="vapC15"
/locus_tag="Rv2010"
CDS 2258273..2258671
/codon_start=1
/transl_table=11
/gene="vapC15"
/locus_tag="Rv2010"
/product="Toxin VapC15"
/note="Rv2010, (MTCY39.07c), len: 132 aa. VapC15,
toxin,part of toxin-antitoxin (TA) operon with Rv2009,
contains PIN domain (See Arcus et al., 2005; Pandey and
Gerdes,2005)."
/db_xref="EnsemblGenomes-Gn:Rv2010"
/db_xref="EnsemblGenomes-Tr:CCP44782"
/db_xref="GOA:P9WF97"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="PDB:4CHG"
/db_xref="UniProtKB/Swiss-Prot:P9WF97"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44782.1"
/translation="MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELL
IGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAIHRRCRRGGDTVRSLIDCQVAAM
ALRIGVAVAHRDRDYEAIRTHCGLRTEPLF"
gene complement(2258854..2259285)
/locus_tag="Rv2011c"
CDS complement(2258854..2259285)
/codon_start=1
/transl_table=11
/locus_tag="Rv2011c"
/product="Conserved hypothetical protein, probable
transcription repressor."
/note="Rv2011c, (MTCY39.06), len: 143 aa. Conserved
hypothetical protein, probable transcription repressor.
Contains IPR011991 Winged helix-turn-helix transcription
repressor DNA-binding domain."
/db_xref="EnsemblGenomes-Gn:Rv2011c"
/db_xref="EnsemblGenomes-Tr:CCP44783"
/db_xref="GOA:P9WLM5"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WLM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44783.1"
/translation="MSDEIARLVADVFELAGLLRRSGEVVAAREGHTQARWQLLSVVS
DRALTVPQAARRLGVTRQGVQRVANDLVVCGLAELRHNPDHRTSPLLVLTENGRRVLQ
AITERAIVVNNRLADAVDPAALQATRDSLRRMIVALKAERP"
gene 2259326..2259820
/locus_tag="Rv2012"
CDS 2259326..2259820
/codon_start=1
/transl_table=11
/locus_tag="Rv2012"
/product="Conserved hypothetical protein"
/note="Rv2012, (MTCY39.05c), len: 164 aa. Conserved
hypothetical protein."
/db_xref="EnsemblGenomes-Gn:Rv2012"
/db_xref="EnsemblGenomes-Tr:CCP44784"
/db_xref="InterPro:IPR009833"
/db_xref="InterPro:IPR036696"
/db_xref="UniProtKB/Swiss-Prot:P9WLM3"
/protein_id="CCP44784.1"
/translation="MLSKSKRSCRRRETLRIGEKMSAPITNLQAAQRDAIMNRPAVNG
FPHLAETLRRAGVRTNTWWLPAMQSLYETDYGPVLDQGVPLIDGVAEVPAFDRTALVT
ALRADQAGQTSFREFAAAAWRAGVLRYVVDLENRTCTYFGLHDQTYMEHYAAVEPSGG
APTS"
mobile_element 2260443..2261670
/mobile_element_type="insertion sequence:IS1607"
/note="IS1607, len: 1228 nt. Vestigial Insertion sequence
element, IS1607."
gene 2260665..2261144
/locus_tag="Rv2013"
CDS 2260665..2261144
/codon_start=1
/transl_table=11
/locus_tag="Rv2013"
/product="Transposase"
/note="Rv2013, (MTCY39.04c), len: 159 aa.
Transposase,shows similarity to N-terminal part of
transposase and insertion element hypothetical proteins.
Length changed since first submission (no clear start
apparent)."
/db_xref="EnsemblGenomes-Gn:Rv2013"
/db_xref="EnsemblGenomes-Tr:CCP44785"
/db_xref="GOA:Q10844"
/db_xref="InterPro:IPR002525"
/db_xref="UniProtKB/TrEMBL:Q10844"
/protein_id="CCP44785.1"
/translation="MDTLLEAGITVVVISPNQLKNLRGRYGSAGNKDDRFDAFVLADT
LRTDRSRLRPLLPDTPATATLRRTCRPRKDLVAHRVALANQLRAHLRVVFPGVVGLFA
DLDSPISLAFLTFLPRFDCQDRADWLSVKRLAGWLAAAGYCGRAPRPAHRCPARRHR"
gene 2261098..2261688
/locus_tag="Rv2014"
CDS 2261098..2261688
/codon_start=1
/transl_table=11
/locus_tag="Rv2014"
/product="Transposase"
/note="Rv2014, (MTCY39.03c), len: 196 aa.
Transposase,similar to insertion elements; possibly made
by frameshifting with respect to Rv2013. Length changed
since first submission."
/db_xref="EnsemblGenomes-Gn:Rv2014"
/db_xref="EnsemblGenomes-Tr:CCP44786"
/db_xref="GOA:Q10843"
/db_xref="InterPro:IPR003346"
/db_xref="UniProtKB/TrEMBL:Q10843"
/protein_id="CCP44786.1"
/translation="MLHDRLTGAPRGATGDEGAANAHITRAMVAALTSVATQIKTLDA
QIAEQLSLHADAHIFTSLPRSGTVRAARLLAEIGDCRARFPTPESLACLAGVAPSTRQ
SGKVKHVGFRWAADKQLRDAVCDFAGDSRRANLWAADRYNRAIARGHDHPHAVRILAR
AWLYAIWHCWQDGAAYHPANHRALQALLNQDQDRAA"
gene complement(2261816..2263072)
/locus_tag="Rv2015c"
CDS complement(2261816..2263072)
/codon_start=1
/transl_table=11
/locus_tag="Rv2015c"
/product="Conserved hypothetical protein"
/note="Rv2015c, (MTV018.02c), len: 418 aa. Conserved
hypothetical protein. Nearly identical to Mycobacterium
tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting
next to ISB9, and ending in IS6110. Different N-terminus
chosen and C-terminus differs as that of Rv1765c has been
truncated by IS6110. Does not show similarities with
transposases. Contains IPR002711 HNH
endonuclease,IPR003615 HNH nuclease, IPR003870 DUF222
domains."
/db_xref="EnsemblGenomes-Gn:Rv2015c"
/db_xref="EnsemblGenomes-Tr:CCP44787"
/db_xref="GOA:O53461"
/db_xref="InterPro:IPR002711"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:O53461"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44787.1"
/translation="MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVA
ELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSL
DQVGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSA
DEQFSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAF
LRLVEAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEA
WFERDGQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGAT
ELANLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPPPAVAP
WPGPTGERADWWWYEPFQPQPPPISN"
gene 2263426..2264001
/locus_tag="Rv2016"
CDS 2263426..2264001
/codon_start=1
/transl_table=11
/locus_tag="Rv2016"
/product="Hypothetical protein"
/note="Rv2016, (MTV018.03), len: 191 aa. Hypothetical
protein."
/db_xref="EnsemblGenomes-Gn:Rv2016"
/db_xref="EnsemblGenomes-Tr:CCP44788"
/db_xref="UniProtKB/TrEMBL:O53462"
/protein_id="CCP44788.1"
/translation="MTELGDKFLAALVGTIRDTRFDIADMRNWRPGWFPTMHSRCLSN
LIHDRIWAHLVTLIASNPGTSIKDKGATREIVVGAHLRLRIKRHHAGDEISTYPTRTA
IEFWQQGSQPAFPGLEEVRIAVGYRWDPDTREIGAPLLSLRDGKDHVIWVVELDEPAA
GVKITWTPIEPTLPSIDFGDLGEDSGASGER"
gene 2263998..2265038
/locus_tag="Rv2017"
CDS 2263998..2265038
/codon_start=1
/transl_table=11
/locus_tag="Rv2017"
/product="Transcriptional regulatory protein"
/note="Rv2017, (MTV018.04), len: 346 aa. Transcriptional
regulator. Contains PS00142 Neutral zinc
metallopeptidases,zinc-binding region signature in
C-terminal half, may be fortuitous. Contains probable
helix-turn-helix motif at aa 18-39 (Score 2243, +6.83 SD);
IPR001387 Helix-turn-helix type 3."
/db_xref="EnsemblGenomes-Gn:Rv2017"
/db_xref="EnsemblGenomes-Tr:CCP44789"
/db_xref="GOA:O53463"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010359"
/db_xref="InterPro:IPR010982"
/db_xref="UniProtKB/TrEMBL:O53463"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44789.1"
/translation="MNGLGDVLAVARKARGLTQIELAELVGLTQPAINRYESGDRDPD
QHIVAKLAEILGVTDDLLIHGNRFRGALAVDAHMRRHKTTKASAWRQLEARLNLLRVH
ASFLFEEVAINSEQHVPAFDPEFTAAEDAARLVRAQWRMPMGPVVNLTRWMEAAGCLV
FEEDFATQRIDGLSQWVDDYPVMLINANAAPDRKRLTLAHELGHLVLHSTNPTENMET
EATAFAAEFLMPESEIRPELRRLDLGKLLELKREWGVSMQALLARAYRMGLVSAEART
KLYKAMNARGWKTKEPGIESIVREKPSLPAHIGMTLRSRGFTDQQAAAIAGYANPADN
PFRPEGGRLHAI"
gene 2265280..2265999
/locus_tag="Rv2018"
CDS 2265280..2265999
/codon_start=1
/transl_table=11
/locus_tag="Rv2018"
/product="Conserved protein"
/note="Rv2018, (MTV018.05), len: 239 aa. Conserved
protein. Contains probable helix-turn-helix motif at aa
215-236 (Score 1175, +3.19 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2018"
/db_xref="EnsemblGenomes-Tr:CCP44790"
/db_xref="GOA:O53464"
/db_xref="InterPro:IPR007367"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR017277"
/db_xref="PDB:5AF3"
/db_xref="UniProtKB/Swiss-Prot:O53464"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44790.1"
/translation="MAGDQELELRFDVPLYTLAEASRYLVVPRATLATWADGYERRPA
NAPAVQGQPIITALPHPTGSHARLPFVGIAEAYVLNAFRRAGVPMQRIRPSLDWLIKN
VGPHALASQDLCTDGAEVLWRFAERSGEGSPDDLVVRGLIVPRSGQYVFKEIVEHYLQ
QISFADDNLASMIRLPQYGDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQA
VADDYGVTPDQLRDALDAIAA"
gene 2265989..2266405
/locus_tag="Rv2019"
CDS 2265989..2266405
/codon_start=1
/transl_table=11
/locus_tag="Rv2019"
/product="Conserved protein"
/note="Rv2019, (MTV018.06), len: 138 aa. Conserved
protein."
/db_xref="EnsemblGenomes-Gn:Rv2019"
/db_xref="EnsemblGenomes-Tr:CCP44791"
/db_xref="GOA:O53465"
/db_xref="InterPro:IPR041375"
/db_xref="UniProtKB/Swiss-Prot:O53465"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44791.1"
/translation="MQPDRNLLADLDHIFVDRSLGAVQVPQLLRDAGFRLTTMREHYG
ETQAQSVSDHKWIAMTAECGWIGFHKDANIRRNAVERRTVLDTGARLFCVPRADILAE
QVAARYIASLAAIARAARFPGPFIYTVHPSKIVRVL"
gene complement(2266421..2266720)
/locus_tag="Rv2020c"
CDS complement(2266421..2266720)
/codon_start=1
/transl_table=11
/locus_tag="Rv2020c"
/product="Conserved hypothetical protein"
/note="Rv2020c, (MTV018.07c), len: 99 aa. Conserved
hypothetical protein, nearly identical to C-terminal part
of hypothetical protein RvD1-Rv2024c' from Mycobacterium
bovis BCG (1606 aa) emb|CAB44655.1| (Y18605). Corresponds
to deletion region RvD1 so probably truncated protein."
/db_xref="EnsemblGenomes-Gn:Rv2020c"
/db_xref="EnsemblGenomes-Tr:CCP44792"
/db_xref="InterPro:IPR041635"
/db_xref="UniProtKB/TrEMBL:O53466"
/protein_id="CCP44792.1"
/translation="MAPGMKWAAKTDHLAIVLLPRHHRRHSRRGRALPARSRSALGWI
IERYRVTTDKASGIVNDPNDWCDEHDDPTYIVDLIKKVTTVSVETMKIVDGLAGG"
gene complement(2266805..2267110)
/locus_tag="Rv2021c"
CDS complement(2266805..2267110)
/codon_start=1
/transl_table=11
/locus_tag="Rv2021c"
/product="Transcriptional regulatory protein"
/note="Rv2021c, (MTV018.08c), len: 101 aa. Regulatory
protein, similar to many. Contains probable
helix-turn-helix at aa 45-66 (Score 1472, +4.20 SD);
IPR001387 Helix-turn-helix type 3 domain."
/db_xref="EnsemblGenomes-Gn:Rv2021c"
/db_xref="EnsemblGenomes-Tr:CCP44793"
/db_xref="GOA:O53467"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010982"
/db_xref="InterPro:IPR039554"
/db_xref="UniProtKB/Swiss-Prot:O53467"
/protein_id="CCP44793.1"
/translation="MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSL
TQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYVSALGGELDITVRLGDETFTLA"
gene complement(2267119..2267724)
/locus_tag="Rv2022c"
CDS complement(2267119..2267724)
/codon_start=1
/transl_table=11
/locus_tag="Rv2022c"
/product="Conserved protein"
/note="Rv2022c, (MTV018.09c), len: 201 aa. Conserved
protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2022c"
/db_xref="EnsemblGenomes-Tr:CCP44794"
/db_xref="InterPro:IPR009241"
/db_xref="UniProtKB/Swiss-Prot:O53468"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44794.1"
/translation="MNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRH
FLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTADVERISAWLNGLDRETYELVFAA
IEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG"
gene complement(2267749..2268108)
/locus_tag="Rv2023c"
CDS complement(2267749..2268108)
/codon_start=1
/transl_table=11
/locus_tag="Rv2023c"
/product="Hypothetical protein"
/note="Rv2023c, (MTV018.10c), len: 119 aa. Hypothetical
protein, alternative upstream start possible."
/db_xref="EnsemblGenomes-Gn:Rv2023c"
/db_xref="EnsemblGenomes-Tr:CCP44795"
/db_xref="UniProtKB/TrEMBL:O53469"
/protein_id="CCP44795.1"
/translation="MAARHARAGRWAAQPRPMLGSGAVRYEVGANIDATGFGGIAAVH
RLVTRLGLVTRLGLVERVDAHSRFSSSNLPKSSRRISGRVSLSGMSNSAAKVVASTSS
SPWGQPLSVGLRRRWRS"
gene complement(2268268..2268726)
/pseudo
/locus_tag="Rv2023A"
CDS complement(2268268..2268726)
/codon_start=1
/transl_table=11
/locus_tag="Rv2023A"
/product="Hypothetical protein, pseudogene"
/note="Rv2023A, len: 152 aa. Hypothetical unknown protein
(pseudogene), equivalent to the C-terminus of
Q8VJS0|MT2080 hypothetical protein from Mycobacterium
tuberculosis strain CDC1551 (225 aa), FASTA scores: opt:
1028, E(): 3.6e-66,(99.342% identity in 152 aa overlap)
and C-terminus of Mb2047c hypothetical protein from
Mycobacterium bovis (225 aa). And N-terminal part
equivalent to the C-terminus of Q9XB17 hypothetical 15.5
kDa protein from Mycobacterium bovis BCG (131 aa), FASTA
scores: opt: 409, E(): 4.2e-22,(98.276% identity in 58 aa
overlap). Note that a deletion of DNA (RvD1 region) in
Mycobacterium tuberculosis strain H37Rv resulted in a
truncated CDS comparatively to Mycobacterium bovis or
Mycobacterium tuberculosis strain CDC1551 genomes (see
citations below)."
/db_xref="PSEUDO:CCP44796.1"
/pseudogene="unknown"
gene complement(2268693..2270240)
/locus_tag="Rv2024c"
CDS complement(2268693..2270240)
/codon_start=1
/transl_table=11
/locus_tag="Rv2024c"
/product="Conserved hypothetical protein"
/note="Rv2024c, (MTV018.11c), len: 515 aa. Conserved
hypothetical protein. Identical to N-terminal part of much
larger hypothetical protein, RvD1-Rv2024c' (1606 aa), from
Mycobacterium bovis BCG:
CAB44655.1|Y18605|13881753|AAK46361.1|AE007059 so probably
truncated. Part of RvD1 chromosomal deletion region."
/db_xref="EnsemblGenomes-Gn:Rv2024c"
/db_xref="EnsemblGenomes-Tr:CCP44797"
/db_xref="GOA:O53470"
/db_xref="InterPro:IPR006935"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR039442"
/db_xref="UniProtKB/TrEMBL:O53470"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44797.1"
/translation="MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDA
VWWWIDWPERRGRTDTGIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGK
TGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEIAESPIDWDIAWPADDLQVNL
TPAKRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGS
ARILLLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTD
ARVLLHEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLA
GDDESNFVRVHDGQYLKAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPE
FHRLSFGEAVERGLLTDYKVMVLTVDQGVIAPRLQQELSGVSGELMLDDASKIVGCWN
GLAKRSGTGIVAGEPPMRRAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACLN
SSRRIQA"
gene complement(2270750..2271748)
/locus_tag="Rv2025c"
CDS complement(2270750..2271748)
/codon_start=1
/transl_table=11
/locus_tag="Rv2025c"
/product="Conserved membrane protein"
/note="Rv2025c, (MTV018.12c), len: 332 aa. Conserved
transmembrane protein, involved in transport of metal
ions,contains IPR002524 Cation efflux protein domain."
/db_xref="EnsemblGenomes-Gn:Rv2025c"
/db_xref="EnsemblGenomes-Tr:CCP44798"
/db_xref="GOA:P9WGF5"
/db_xref="InterPro:IPR002524"
/db_xref="InterPro:IPR027469"
/db_xref="InterPro:IPR027470"
/db_xref="InterPro:IPR036837"
/db_xref="UniProtKB/Swiss-Prot:P9WGF5"
/protein_id="CCP44798.1"
/translation="MTHDHAHSRGVPAMIKEIFAPHSHDAADSVDDTLESTAAGIRTV
KISLLVLGLTALIQIVIVVMSGSVALAADTIHNFADALTAVPLWIAFALGAKPATRRY
TYGFGRVEDLAGSFVVAMITMSAIIAGYEAIARLIHPQQIEHVGWVALAGLVGFIGNE
WVALYRIRVGHRIGSAALIADGLHARTDGFTSLAVLCSAGGVALGFPLADPIVGLLIT
AAILAVLRTAARDVFRRLLDGVDPAMVDAAEQALAARPGVQAVRSVRMRWIGHRLHAD
AELDVDPALDLAQAHRIAHDAEHELTHTVPKLTTALIHAYPAEHGSSIPDRGRTVE"
gene complement(2271863..2272747)
/locus_tag="Rv2026c"
CDS complement(2271863..2272747)
/codon_start=1
/transl_table=11
/locus_tag="Rv2026c"
/product="Universal stress protein family protein"
/note="Rv2026c, (MTV018.13c), len: 294 aa. Universal
stress protein family protein, contains IPR006016 UspA
domain."
/db_xref="EnsemblGenomes-Gn:Rv2026c"
/db_xref="EnsemblGenomes-Tr:CCP44799"
/db_xref="GOA:P9WFD1"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="UniProtKB/Swiss-Prot:P9WFD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44799.1"
/translation="MSAATAKYGILVGVDGSAQSNAAVAWAAREAVMRQLPITLLHIV
APVVVGWPVGQLYANMTEWQKDNAQQVIEQAREALTNSLGESKPPQVHTELVFSNVVP
TLIDASQQAWLMVVGSQGMGALGRLLLGSISTALLHHARCPVAIIHSGNGATPDSDAP
VLVGIDGSPASEAATALAFDEASRRRVDLVALHAWTDLGMFPVLGMDWREREKREAEV
LAERLAGWQEQYPDVRVHRSLVCDKPARWLLEHSEQAQLVVVGSHGRGGFSGMLLGSV
SSAVAHSVRIPVIVVRPS"
gene complement(2272787..2274508)
/gene="dosT"
/locus_tag="Rv2027c"
CDS complement(2272787..2274508)
/codon_start=1
/transl_table=11
/gene="dosT"
/locus_tag="Rv2027c"
/product="Two component sensor histidine kinase DosT"
/note="Rv2027c, (MTV018.14c), len: 573 aa. DosT, Histidine
kinase response regulator, highly similar to others."
/db_xref="EnsemblGenomes-Gn:Rv2027c"
/db_xref="EnsemblGenomes-Tr:CCP44800"
/db_xref="GOA:P9WGK1"
/db_xref="InterPro:IPR003018"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR011712"
/db_xref="InterPro:IPR029016"
/db_xref="InterPro:IPR036890"
/db_xref="PDB:2VZW"
/db_xref="PDB:3ZXQ"
/db_xref="UniProtKB/Swiss-Prot:P9WGK1"
/protein_id="CCP44800.1"
/translation="MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRD
RLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGID
EETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRI
RDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATR
DIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGE
ISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAG
VLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLH
DHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRA
TGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANAT
SLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLL
RWSAPLR"
gene complement(2274569..2275408)
/locus_tag="Rv2028c"
CDS complement(2274569..2275408)
/codon_start=1
/transl_table=11
/locus_tag="Rv2028c"
/product="Universal stress protein family protein"
/note="Rv2028c, (MTV018.15c), len: 279 aa. Universal
stress protein family protein, highly similar to many,
contains IPR006016 UspA domain."
/db_xref="EnsemblGenomes-Gn:Rv2028c"
/db_xref="EnsemblGenomes-Tr:CCP44801"
/db_xref="GOA:P9WFD9"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="UniProtKB/Swiss-Prot:P9WFD9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44801.1"
/translation="MNQSHKPPSIVVGIDGSKPAVQAALWAVDEAASRDIPLRLLYAI
EPDDPGYAAHGAAARKLAAAENAVRYAFTAVEAADRPVKVEVEITQERPVTSLIRASA
AAALVCVGAIGVHHFRPERVGSTAAALALSAQCPVAIVRPHRVPIGRDAAWIVVEADG
SSDIGVLLGAVMAEARLRDSPVRVVTCRQSGVGDTGDDVRASLDRWLARWQPRYPDVR
VQSAAVHGELLDYLAGLGRSVHMVVLSASDQEHVEQLVGAPGNAVLQEAGCTLLVVGQ
QYL"
gene complement(2275405..2276424)
/gene="pfkB"
/locus_tag="Rv2029c"
CDS complement(2275405..2276424)
/codon_start=1
/transl_table=11
/gene="pfkB"
/locus_tag="Rv2029c"
/product="6-phosphofructokinase PfkB (phosphohexokinase)
(phosphofructokinase)"
/note="Rv2029c, (MTV018.16c), len: 339 aa.
PfkB,phosphofructokinase. Contains PS00583 pfkB family of
carbohydrate kinases signature 1. Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2029c"
/db_xref="EnsemblGenomes-Tr:CCP44802"
/db_xref="GOA:P9WID3"
/db_xref="InterPro:IPR002173"
/db_xref="InterPro:IPR011611"
/db_xref="InterPro:IPR017583"
/db_xref="InterPro:IPR029056"
/db_xref="UniProtKB/Swiss-Prot:P9WID3"
/inference="protein motif:PROSITE:PS00583"
/protein_id="CCP44802.1"
/translation="MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR
YDPGGGGINVARIVHVLGGCSTALFPAGGSTGSLLMALLGDAGVPFRVIPIAASTRES
FTVNESRTAKQYRFVLPGPSLTVAEQEQCLDELRGAAASAAFVVASGSLPPGVAADYY
QRVADICRRSSTPLILDTSGGGLQHISSGVFLLKASVRELRECVGSELLTEPEQLAAA
HELIDRGRAEVVVVSLGSQGALLATRHASHRFSSIPMTAVSGVGAGDAMVAAITVGLS
RGWSLIKSVRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVN
PEASP"
gene complement(2276441..2278486)
/locus_tag="Rv2030c"
CDS complement(2276441..2278486)
/codon_start=1
/transl_table=11
/locus_tag="Rv2030c"
/product="Conserved protein"
/note="Rv2030c, (MTV018.17c), len: 681 aa. Conserved
protein. Predicted possible vaccine candidate (See Zvi et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2030c"
/db_xref="EnsemblGenomes-Tr:CCP44803"
/db_xref="GOA:P9WLM1"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR007815"
/db_xref="InterPro:IPR014622"
/db_xref="InterPro:IPR029057"
/db_xref="UniProtKB/Swiss-Prot:P9WLM1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44803.1"
/translation="MLMTAAADVTRRSPRRVFRDRREAGRVLAELLAAYRDQPDVIVL
GLARGGLPVAWEVAAALHAPLDAFVVRKLGAPGHDEFAVGALASGGRVVVNDDVVRGL
RITPQQLRDIAEREGRELLRRESAYRGERPPTDITGKTVIVVDDGLATGASMFAAVQA
LRDAQPAQIVIAVPAAPESTCREFAGLVDDVVCATMPTPFLAVGESFWDFRQVTDEEV
RRLLATPTAGPSLRRPAASTAADVLRRVAIDAPGGVPTHEVLAELVGDARIVLIGESS
HGTHEFYQARAAMTQWLIEEKGFGAVAAEADWPDAYRVNRYVRGLGEDTNADEALSGF
ERFPAWMWRNTVVRDFVEWLRTRNQRYESGALRQAGFYGLDLYSLHRSIQEVISYLDK
VDPRAAARARARYACFDHACADDGQAYGFAAAFGAGPSCEREAVEQLVDVQRNALAYA
RQDGLLAEDELFYAQQNAQTVRDAEVYYRAMFSGRVTSWNLRDQHMAQTLGSLLTHLD
RHLDAPPARIVVWAHNSHVGDARATEVWADGQLTLGQIVRERYGDESRSIGFSTYTGT
VTAASEWGGIAQRKAVRPALHGSVEELFHQTADSFLVSARLSRDAEAPLDVVRLGRAI
GVVYLPATERQSHYLHVRPADQFDAMIHIDQTRALEPLEVTSRWIAGENPETYPTGL"
gene complement(2278498..2278932)
/gene="hspX"
/gene_synonym="acr"
/locus_tag="Rv2031c"
CDS complement(2278498..2278932)
/codon_start=1
/transl_table=11
/gene="hspX"
/gene_synonym="acr"
/locus_tag="Rv2031c"
/product="Heat shock protein HspX (alpha-crystallin
homolog) (14 kDa antigen) (HSP16.3)"
/note="Rv2031c, (MTV018.18c), len: 144 aa. HspX, heat
shock protein localized in the inner membrane (see
citations below). Identical to P30223|14KD_MYCTU 14 KD
antigen (16 kDa antigen) (HSP 16.3) of Mycobacterium
tuberculosis (143 aa). Belongs to the small heat shock
protein (HSP20) family. Also known as alpha-crystallin and
gene as acr (see some citations below). Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2031c"
/db_xref="EnsemblGenomes-Tr:CCP44804"
/db_xref="GOA:P9WMK1"
/db_xref="InterPro:IPR002068"
/db_xref="InterPro:IPR008978"
/db_xref="UniProtKB/Swiss-Prot:P9WMK1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44804.1"
/translation="MATTLPVQRHPRSLFPEFSELFAAFPSFAGLRPTFDTRLMRLED
EMKEGRYEVRAELPGVDPDKDVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTV
SLPVGADEDDIKATYDKGILTVSVAVSEGKPTEKHIQIRSTN"
gene 2279129..2280124
/gene="acg"
/locus_tag="Rv2032"
CDS 2279129..2280124
/codon_start=1
/transl_table=11
/gene="acg"
/locus_tag="Rv2032"
/product="Conserved protein Acg"
/note="Rv2032, (MTV018.19), len: 331 aa. Acg (for
acr-coregulated gene), conserved protein possibly member
of a superfamily of classical nitroreductases (see
Purkayastha et al., 2002), similar to Rv3127 and Rv3131.
Predicted possible vaccine candidate (See Zvi et al.,
2008)."
/db_xref="EnsemblGenomes-Gn:Rv2032"
/db_xref="EnsemblGenomes-Tr:CCP44805"
/db_xref="GOA:P9WIZ9"
/db_xref="InterPro:IPR000415"
/db_xref="UniProtKB/Swiss-Prot:P9WIZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44805.1"
/translation="MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLD
KDRVLYATDHSGREALLGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSP
ADFVTEGHRLRADAILLRRTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRP
ELAAASKLTESLRLYDSSYHAELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPV
VANTDRRPEFGHDRSKVLVLSTYDNERASLLRCGEMLSAVLLDATMAGLATCTLTHIT
ELHASRDLVAALIGQPATPQALVRVGLAPEMEEPPPATPRRPIDEVFHVRAKDHR"
gene complement(2280240..2281082)
/locus_tag="Rv2033c"
CDS complement(2280240..2281082)
/codon_start=1
/transl_table=11
/locus_tag="Rv2033c"
/product="Conserved hypothetical protein"
/note="Rv2033c, (MTV018.20), len: 280 aa. Conserved
hypothetical protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2033c"
/db_xref="EnsemblGenomes-Tr:CCP44806"
/db_xref="GOA:O53477"
/db_xref="InterPro:IPR021447"
/db_xref="UniProtKB/TrEMBL:O53477"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44806.1"
/translation="MLDRYGTDVLAAGGRRRPRSVEHPVELGMVVEDAETGYVGAVVR
VEYGRIDLEDRYGKTRGFPLGPGYLLDGLPVILTAPRCAAAAGPRRTASGSVAVPGAR
ARVARASRIYVEGRHDAELIAAVWGADLRIEGVVVEHLGGVDDLVEIVAKFRPGPRRR
LGVLVDHLVAGSKEARIAEVVRRGPGGSDTLVVGHPYVDIWQAVKPQRVGLAAWPRVP
RHIEWKHGVCDALGWPHADQADIAAAWRRIRSQVRDWTDLEPALIGRVEELIDFVTQP
AGDE"
gene 2281294..2281617
/locus_tag="Rv2034"
CDS 2281294..2281617
/codon_start=1
/transl_table=11
/locus_tag="Rv2034"
/product="ArsR repressor protein"
/note="Rv2034, (MTV018.21), len: 107 aa. Repressor protein
belonging to the ArsR family. Contains probable
helix-turn-helix at aa 32-53 (S core 1350, +3.78 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2034"
/db_xref="EnsemblGenomes-Tr:CCP44807"
/db_xref="GOA:O53478"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:O53478"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44807.1"
/translation="MSTYRSPDRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSR
PAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAALRTDLDRFWTRALTGYAQLIDS
EGDDT"
gene 2281614..2282102
/locus_tag="Rv2035"
CDS 2281614..2282102
/codon_start=1
/transl_table=11
/locus_tag="Rv2035"
/product="Conserved hypothetical protein"
/note="Rv2035, (MTV018.22), len: 162 aa. Conserved
hypothetical protein, similar to many. Contains IPR013538
Activator of Hsp90 ATPase homologue 1-like."
/db_xref="EnsemblGenomes-Gn:Rv2035"
/db_xref="EnsemblGenomes-Tr:CCP44808"
/db_xref="InterPro:IPR013538"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O53479"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44808.1"
/translation="MTRPRTDAIHHHVVVNAPIERAFAVFTTRFGDFKPREHNLLAIP
ITETVFECHAGGHIYDRGVDGSVCKWARVLVYEPPSRVLFTWDIGPTWRPETDLAKTS
EVEVRFTAQSAETTRVDLEHRHLDRHGPGWESVADGVDSEAGWPLYLRRYTDLLCIQV
QP"
gene 2282099..2282740
/locus_tag="Rv2036"
CDS 2282099..2282740
/codon_start=1
/transl_table=11
/locus_tag="Rv2036"
/product="Conserved hypothetical protein"
/note="Rv2036, (MTV018.23), len: 213 aa. Conserved
hypothetical protein; similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2036"
/db_xref="EnsemblGenomes-Tr:CCP44809"
/db_xref="GOA:O53480"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR024344"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/TrEMBL:O53480"
/protein_id="CCP44809.1"
/translation="MIAADDDTEKSMMDMARAERAELAAFLTTLTLQQWETPSLCAGW
SVKEVVAHMISYEDLGVFGLLKRFAKGRIVRANEVGVDEFAGLSPQELADYVGRHLQP
RGLTAGFGGMIALVDGMIHHQDIRRPLGQPRTIPAQRLDRVLRLMPKNPRLRARPRIK
GLRLRATDLDWTIGTGPEVTGPGEALLMAMAGRPAAVSDLSGPGKPTLAGRLG"
gene complement(2282747..2283721)
/locus_tag="Rv2037c"
CDS complement(2282747..2283721)
/codon_start=1
/transl_table=11
/locus_tag="Rv2037c"
/product="Conserved transmembrane protein"
/note="Rv2037c, (MTV018.24c), len: 324 aa. Conserved
transmembrane protein, similar to many. Alternative
nucleotide at position 2282787 (C->T; C312Y) has been
observed. Contains IPR016035 Acyl transferase/acyl
hydrolase/lysophospholipase motif."
/db_xref="EnsemblGenomes-Gn:Rv2037c"
/db_xref="EnsemblGenomes-Tr:CCP44810"
/db_xref="GOA:L0TB61"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR016035"
/db_xref="UniProtKB/TrEMBL:L0TB61"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44810.1"
/translation="MALVSTARVDLVCEGGGVRGIGLVGAVDALADAGYRFPRVAGSS
AGAIVASLVAALQTAGEPVTRLAEMMRSIDYPKFLDRNLIGHVPLIGGGLSLLLSDGV
YRGAYLEQLLGGLLADLGVHTFGDLRTGEAPEQFAWSLVVTASDLSRRRLVRIPWDLD
SYGIHPDDFSVARAVHASSAIPFVFEPVRVRGATWVDGGLLSNFPVALFDRTDAEPRW
PTFGIRLSARPGIPPTRPVQGPVSLGIAAIETLVSNQDNAYIDDPCTVRRTIFVPAHD
VSPIDFDITAEQREALYQRGFQAGQKFLANWNYADCLADCGGPFTPSL"
gene complement(2283723..2284796)
/locus_tag="Rv2038c"
CDS complement(2283723..2284796)
/codon_start=1
/transl_table=11
/locus_tag="Rv2038c"
/product="Probable sugar-transport ATP-binding protein ABC
transporter"
/note="Rv2038c, (MTV018.25c), len: 357 aa. Probable
sugar-transport ATP-binding protein ABC transporter (see
citation below), similar to many. Contains PS00211 ABC
transporters family signature and PS00017 ATP/GTP-binding
site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2038c"
/db_xref="EnsemblGenomes-Tr:CCP44811"
/db_xref="GOA:O53482"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR008995"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR040582"
/db_xref="UniProtKB/TrEMBL:O53482"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44811.1"
/translation="MASVSFEQATRRYPGTDRPALDRLDLIVGDGEFVVLVGPSGCGK
TTSLRMVAGLETLDCGRIRIGERDVTEVDPKDRDVAMVFQNYALYPHMTVAQNMGFAL
KVAKIGKAEIRERVLAAAKLLDLQSYLDRKPKDLSGGQRQRVAMGRAIVRRPQVFLMD
EPLSNLDAKLRGQTRNQIAALQRQLGTTTVYVTHDQVEAMTMGDRVAVLSDGVLQQCA
SPRELYRNPGNVFVAGFIGSPAMNLFRLSIADSTVSLGDWQILLPRAVVGTAAEVIIG
VRPEHLELGGAGIEMDVDMVEELGADAYLYGRIVSGGCEMDQSIVARVDGRGPPERGS
RVRLCPTPGHLHFFAVDGRRIPG"
gene complement(2284799..2285641)
/locus_tag="Rv2039c"
CDS complement(2284799..2285641)
/codon_start=1
/transl_table=11
/locus_tag="Rv2039c"
/product="Probable sugar-transport integral membrane
protein ABC transporter"
/note="Rv2039c, (MTV018.26c), len: 280 aa. Probable
sugar-transport integral membrane protein ABC transporter
(see citation below), similar to many. Contains PS00402
Binding-protein-dependent transport systems inner membrane
comp signature. Also contains possible helix-turn-helix
motif at aa 171-192, although this is probably
fortuitous."
/db_xref="EnsemblGenomes-Gn:Rv2039c"
/db_xref="EnsemblGenomes-Tr:CCP44812"
/db_xref="GOA:O53483"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:O53483"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP44812.1"
/translation="MGWADRIVHRHFIRGLALYAGLIGIAWCALFPIIWALSGSLKAD
GEVTEPTLFPSHPQWSNYREVFALMPFWRMFFNTVLYAGCVTAGQVFFCSLAGYAFAR
LQFRGRDTLFVLYLSTLMVPLTVTVIPQVILMRIVGWVDTPWAMIVPGLFGSAFGTYL
MRQFFRTLPTDLEEAAILDGCSPWQIYWRILLPHSRPAVLVLGVLTWVNVWNDFLWPL
LMIQRNSLATLTLGLVRLRGEYVARWPVLMAASMLMLVPLVILYAVAQRSFVRGIAVT
GLGG"
gene complement(2285628..2286530)
/locus_tag="Rv2040c"
CDS complement(2285628..2286530)
/codon_start=1
/transl_table=11
/locus_tag="Rv2040c"
/product="Probable sugar-transport integral membrane
protein ABC transporter"
/note="Rv2040c, (MTV018.27c), len: 300 aa. Probable
sugar-transport integral membrane protein ABC transporter
(see citation below), similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2040c"
/db_xref="EnsemblGenomes-Tr:CCP44813"
/db_xref="GOA:O53484"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:O53484"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP44813.1"
/translation="MTRRRGRRAWAGRMFVAPNLAAVVVFMLFPLGFSLYMSFQKWDL
FTHATFVRLDNFRNLFTSDPLFLIAVVNTAVYTVGTVVPTVIVSLVVAAFLNRKIKGI
SLFRTVVFLPLAISSVVMAVVWQFVFNTDNGLLNIMLGWLGIGPIPWLIEPRWAMVSL
CLVSVWRSVPFATVVLLAAMQGVPETVYEAARIDGAGEIRQFVSITVPLIRGALSFVV
VISIIHAFQAFDLVYVLTGANGGPETATYVLGIMLFQHAFSFLEFGYASALAWVMFAI
LLVLTVLQLRITHRRSWEASRGLG"
gene complement(2286527..2287846)
/locus_tag="Rv2041c"
CDS complement(2286527..2287846)
/codon_start=1
/transl_table=11
/locus_tag="Rv2041c"
/product="Probable sugar-binding lipoprotein"
/note="Rv2041c, (MTV018.28c), len: 439 aa. Probable
sugar-binding lipoprotein component of sugar transport
system, similar to many. Contains signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2041c"
/db_xref="EnsemblGenomes-Tr:CCP44814"
/db_xref="GOA:O53485"
/db_xref="InterPro:IPR006059"
/db_xref="InterPro:IPR006311"
/db_xref="UniProtKB/TrEMBL:O53485"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44814.1"
/translation="MVNKPFERRSLLRGAGALTAASLAPWAAGCAADDDDALTFFFAA
NPDELRPRMRVVNEFQRRYPDIKVRALLSGPGVMQQLATFCAGGKCPDVLMAWELTYA
ELADRGVLLDLNTLLARDQAFAAELKSDSIGALYETFTFNGGQYAFPEQWSGNFLFYN
KQLFDDAGVPPPPGSWERPWSFAEFLDAAQALTKQGRSGRDRQWGFVNAWVSFYAAGL
FAMNNGVPWSVPRMNPTHLNFDHDGFLEAVQFYADLTNKHKVAPSAAEQQSMSTADLF
SVGKAGIALAGHWRYQTFDRADGLDFDVAPLPIGPRGRAACSDIGVTGLAIAATSRRK
DQAWEFVKFATGPVGQALIGESRLFVPVLRSAINSHGFANAHRRVGNLAVLSEGPAYS
EGLPVTPAWEKIAALMDRYFGPVLRGSRPATSLTGLSQAVDEVLRNP"
gene complement(2287884..2288681)
/locus_tag="Rv2042c"
CDS complement(2287884..2288681)
/codon_start=1
/transl_table=11
/locus_tag="Rv2042c"
/product="Conserved protein"
/note="Rv2042c, (MTV018.29c), len: 265 aa. Conserved
protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2042c"
/db_xref="EnsemblGenomes-Tr:CCP44815"
/db_xref="GOA:O53486"
/db_xref="InterPro:IPR002075"
/db_xref="InterPro:IPR032710"
/db_xref="UniProtKB/TrEMBL:O53486"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44815.1"
/translation="MAPPNRDELLAAVERSPQAAAAHDRAGWVGLFTGDARVEDPVGS
QPQVGHEAIGRFYDTFIGPRDITFHRDLDIVSGTVVLRDLELEVAMDSAVTVFIPAFL
RYDLRPVTGEWQIAALRAYWELPAMMLQFLRTGSGATRPALQLSRALLGNQGLGGTAG
FLTGFRRAGRRHKKLVETFLNAASRADKSAAYHALSRTATMTLGEDELLDIVELFEQL
RGASWTKVTGAGSTVAVSLASDHRRGIMFADVPWRGNRINRIRYFPA"
gene complement(2288681..2289241)
/gene="pncA"
/locus_tag="Rv2043c"
CDS complement(2288681..2289241)
/codon_start=1
/transl_table=11
/gene="pncA"
/locus_tag="Rv2043c"
/product="Pyrazinamidase/nicotinamidase PncA (PZase)"
/note="Rv2043c, (MTV018.30c), len: 186 aa.
PncA,pyrazinamidase/nicotinamidase (see citations
below),involved in susceptibility or resistance to
antituberculous drug pyrazinamide."
/db_xref="EnsemblGenomes-Gn:Rv2043c"
/db_xref="EnsemblGenomes-Tr:CCP44816"
/db_xref="GOA:I6XD65"
/db_xref="InterPro:IPR000868"
/db_xref="InterPro:IPR036380"
/db_xref="PDB:3PL1"
/db_xref="UniProtKB/Swiss-Prot:I6XD65"
/protein_id="CCP44816.1"
/translation="MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHV
VATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGA
YSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLT
AGVSADTTVAALEEMRTASVELVCSS"
gene complement(2289282..2289599)
/locus_tag="Rv2044c"
CDS complement(2289282..2289599)
/codon_start=1
/transl_table=11
/locus_tag="Rv2044c"
/product="Conserved hypothetical protein"
/note="Rv2044c, (MTV018.31c), len: 105 aa. Conserved
hypothetical protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2044c"
/db_xref="EnsemblGenomes-Tr:CCP44817"
/db_xref="GOA:O53487"
/db_xref="InterPro:IPR021218"
/db_xref="UniProtKB/TrEMBL:O53487"
/protein_id="CCP44817.1"
/translation="MHFAFIAYVLAGGFLALRWRRTMWLHVPAVIWGIGIAAKRVDCP
LTWVERWARTKAAMTPLSPDGFVAHYITGVIYPAGWVAAAQLVMFAIVAASWTLYLWL
PRR"
gene complement(2289685..2291220)
/gene="lipT"
/locus_tag="Rv2045c"
CDS complement(2289685..2291220)
/codon_start=1
/transl_table=11
/gene="lipT"
/locus_tag="Rv2045c"
/product="Carboxylesterase LipT"
/note="Rv2045c, (MTV018.32c), len: 511 aa.
LipT,carboxylesterase, similar to many. Contains PS00941
Carboxylesterases type-B signature 2. Contains PS00122
Carboxylesterases type-B serine active site."
/db_xref="EnsemblGenomes-Gn:Rv2045c"
/db_xref="EnsemblGenomes-Tr:CCP44818"
/db_xref="GOA:O53488"
/db_xref="InterPro:IPR002018"
/db_xref="InterPro:IPR002168"
/db_xref="InterPro:IPR019819"
/db_xref="InterPro:IPR019826"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53488"
/inference="protein motif:PROSITE:PS00122"
/inference="protein motif:PROSITE:PS00941"
/protein_id="CCP44818.1"
/translation="MALESATVGSMHERTVRARTATGIVEGFTRDGVHRWRSIPYARA
PVGSLRFRAPQPAQPWPGVRHCHTFANCAPQQRRYTVMGIGRYQTRSEDCLTLNVVTP
EEPATQPLPVMVFIHGGGYILGSSATPIYDGAALARRGCVYVSVNYRLGALGCLDLSS
LSTPQITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPA
AKGLFARAISESPAAGMVRSREVAAEFAARFANLIGARTQDAANALMQASPAQLVEAQ
HHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVGTNAEEGRLFTR
FLGMLPTNEPMVEELLSGMKPADRERITAAYPNYPAPSACIQLGGDFAFSSAAWQIAE
AHGANAPTYLYRYDYAPRTLRWSGFGATHATELFAVFDIYRTRFGALLTAAADRRAAL
RVSNEVQRRWRCFSQIGVPGDDWPAYTQDDRAVLVFDRRCRIEFDPHQHRRIAWDGFS
LAN"
gene 2291269..2291925
/gene="lppI"
/locus_tag="Rv2046"
CDS 2291269..2291925
/codon_start=1
/transl_table=11
/gene="lppI"
/locus_tag="Rv2046"
/product="Probable lipoprotein LppI"
/note="Rv2046, (MTV018.33), len: 218 aa. Probable
lppI,lipoprotein contains signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2046"
/db_xref="EnsemblGenomes-Tr:CCP44819"
/db_xref="GOA:O53489"
/db_xref="UniProtKB/TrEMBL:O53489"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44819.1"
/translation="MRIAALVAVSLLIAGCSREVGGDVGQSQTIAPPAPAPSAAPSTP
PAAGAPITTIVSWIEAGHPVDPAAYHVATRDGVTTQLGDDVAFSASSGTVACMTDARH
TSGTLACLVRLANPPPRPETAYGEWKGGWVDFDGIHLQVGSARADPGPFVYGNGPELA
NGDTLSIGDYRCRSYQAGLFCVNYAHQSAVRFASAGIEPFGCLKPAPPPDGVGVAFGC
"
gene complement(2291962..2294526)
/locus_tag="Rv2047c"
CDS complement(2291962..2294526)
/codon_start=1
/transl_table=11
/locus_tag="Rv2047c"
/product="Conserved hypothetical protein"
/note="Rv2047c, (MTV018.34c), len: 854 aa. Conserved
hypothetical protein, similar to many. Contains IPR016040
NAD(P)-binding domain at N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv2047c"
/db_xref="EnsemblGenomes-Tr:CCP44820"
/db_xref="GOA:P9WIH5"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR008279"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036637"
/db_xref="UniProtKB/Swiss-Prot:P9WIH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44820.1"
/translation="MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADF
IAADIRDATAVESAMTGADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTS
SGHQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHS
DDAQRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAE
LELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANI
QDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSAS
VTVRGLRAGGVGIAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKP
ATIVSNSGFFGPSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPR
DTDAYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNV
LLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEA
PEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAPQPPTPVIP
LRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLL
VDEIDALPADVSGLVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVG
VCGGRVRGRVRIVRPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAA
VVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR"
gene complement(2294531..2306986)
/gene="pks12"
/locus_tag="Rv2048c"
CDS complement(2294531..2306986)
/codon_start=1
/transl_table=11
/gene="pks12"
/locus_tag="Rv2048c"
/product="Polyketide synthase Pks12"
/note="Rv2048c, (MTV018.35c), len: 4151 aa.
Pks12,polyketide synthase similar to many. Contains 2x
PS00012 Phosphopantetheine attachment site, 2x PS00606
Beta-ketoacyl synthases active site, and PS00343
Gram-positive cocci surface proteins 'anchoring'
hexapeptide. Nucleotide position 2297976 in the genome
sequence has been corrected, G:A resulting in S3004L."
/db_xref="EnsemblGenomes-Gn:Rv2048c"
/db_xref="EnsemblGenomes-Tr:CCP44821"
/db_xref="GOA:I6XD69"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/TrEMBL:I6XD69"
/inference="protein motif:PROSITE:PS00012"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00343"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44821.1"
/translation="MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSC
RFPGGVDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDG
VADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVG
GYGMLAEEIEGYRLTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLR
SGECDLALAGGVTVNATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQ
RLSDARRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDV
VEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKM
VLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGVSSFGISGTN
AHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVG
WSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQG
SQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPV
LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGL
AGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKE
LRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADY
WYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAACTDGDSEAIVVPT
LGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGA
DVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFV
ELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRADAQ
AGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRGYRYGPAFRGLTA
MWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELALPFAWQGVSL
HATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGSGPD
RLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDHES
GVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMA
LATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPN
ADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVG
DSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQ
RVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED
KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVR
YRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGK
VVMLMPGSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVA
ELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPDRV
DVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR
RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDE
PFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPE
AEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSL
SPTLIFDYPTPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNS
PDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAF
FGVGPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAE
PVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLA
LAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARR
LGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTG
TTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHE
LLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEA
VPVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRS
VFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMG
MGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVAL
FRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGRLMQALPAGGAMVA
VQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHA
FHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQLAGDDFGSAAYWRRHIRQAVRF
ADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTTMSALRKDRPEPATLTNAVA
QGFVTGMDLDWRAVVGEAQFVELPTYAFQRRRFWLSGDGVAADAAGLGLAASEHALLG
AVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVD
ELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRGDVGTGWVLHAEGALRAGSA
EPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPA
DAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGVSLHAAGASAVRA
RIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGPDRLFEVTWSPQ
PSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVLQSWLTRDGAG
VLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVV
TTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDA
DAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVG
DRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQ
RVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED
KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVR
YRAFDLFEPGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK
VVMLMPGSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVA
ELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPDRV
DVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR
RAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSADALQLFDTAMIVDE
PFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGL
PEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEMRNRLKSATGL
ALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVKRLRQAG
VLDLLLALANETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE"
gene 2299745..2299886
/gene="ASpks"
ncRNA 2299745..2299886
/gene="ASpks"
/product="Putative small regulatory RNA"
/note="ASpks, putative small regulatory RNA (See Arnvig
and Young, 2009). Alternate 5'-ends at positions 2299785
and 2299796. Alternate 3'-end at position 2299873. This
sequence is repeated in pks12|Rv2048c at position
2305814-2305955."
/ncRNA_class="other"
gene complement(2307293..2307517)
/locus_tag="Rv2049c"
CDS complement(2307293..2307517)
/codon_start=1
/transl_table=11
/locus_tag="Rv2049c"
/product="Conserved hypothetical protein"
/note="Rv2049c, (MTV018.36c), len: 74 aa. Conserved
hypothetical protein."
/db_xref="EnsemblGenomes-Gn:Rv2049c"
/db_xref="EnsemblGenomes-Tr:CCP44822"
/db_xref="UniProtKB/TrEMBL:O53491"
/protein_id="CCP44822.1"
/translation="MLTRGEVRALPADAVVLSADDAADLSDRVYQVRCAAEDVVTALD
EGAAATELRDLCDELIRAARAADGWRRAGA"
gene 2307821..2308156
/locus_tag="Rv2050"
CDS 2307821..2308156
/codon_start=1
/transl_table=11
/locus_tag="Rv2050"
/product="Conserved protein"
/note="Rv2050, (MTV018.37), len: 111 aa. Conserved
protein,similar to many. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004)."
/db_xref="EnsemblGenomes-Gn:Rv2050"
/db_xref="EnsemblGenomes-Tr:CCP44823"
/db_xref="GOA:P9WHJ5"
/db_xref="InterPro:IPR025182"
/db_xref="InterPro:IPR038638"
/db_xref="PDB:2M4V"
/db_xref="PDB:2M6P"
/db_xref="PDB:4X8K"
/db_xref="PDB:6BZO"
/db_xref="PDB:6C04"
/db_xref="PDB:6C05"
/db_xref="PDB:6C06"
/db_xref="PDB:6EDT"
/db_xref="PDB:6EE8"
/db_xref="PDB:6EEC"
/db_xref="PDB:6M7J"
/db_xref="UniProtKB/Swiss-Prot:P9WHJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44823.1"
/translation="MADRVLRGSRLGAVSYETDRNHDLAPRQIARYRTDNGEEFEVPF
ADDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRTHWDMLLERRSIEELEELLKERL
ELIRSRRRG"
gene complement(2308131..2310755)
/gene="ppm1"
/locus_tag="Rv2051c"
CDS complement(2308131..2310755)
/codon_start=1
/transl_table=11
/gene="ppm1"
/locus_tag="Rv2051c"
/product="Polyprenol-monophosphomannose synthase Ppm1"
/note="Rv2051c, (MTV018.38c), len: 874 aa.
Ppm1,Polyprenol-monophosphomannose synthase. Transfers
mannose from GDP-Mannose to all endogenous
polyprenol-phosphates in Mycobacterium tuberculosis,
proven experimentally (A. Baulard, Institut Pasteur de
Lille: see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv2051c"
/db_xref="EnsemblGenomes-Tr:CCP44824"
/db_xref="GOA:O53493"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR003010"
/db_xref="InterPro:IPR004563"
/db_xref="InterPro:IPR029044"
/db_xref="InterPro:IPR036526"
/db_xref="InterPro:IPR039528"
/db_xref="UniProtKB/Swiss-Prot:O53493"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44824.1"
/translation="MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNC
WWAAVVALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLALAT
TCALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWGSVAFGQAEGP
LLPLVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQGDAPPAVVLPAACICLVL
FAAIVVWPQVRHAGSGSGGEPTVTVAVVQGNVPRLGLDFNAQRRAVLDNHVEETLRLA
ADVHAGLAQQPQFVIWPENSSDIDPFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRP
RENPEWTNTAIVWNPGTGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGN
GTGVVRIAGVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFA
KVRAVEHDRYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTRLTPATRWG
PILQWILVGAAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDAPPGRSEASGPPALSES
DDELIQPEQGGRHSSGFGRHRATSRSYMTTGQPAPPAPGNRPSQRVLVIIPTFNEREN
LPVIHRRLTQACPAVHVLVVDDSSPDGTGQLADELAQADPGRTHVMHRTAKNGLGAAY
LAGFAWGLSREYSVLVEMDADGSHAPEQLQRLLDAVDAGADLAIGSRYVAGGTVRNWP
WRRLVLSKTANTYSRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQIDLTW
RTVSNGFVVTEVPITFTERELGVSKMSGSNIREALVKVARWGIEGRLSRSDHARARPD
IARPGAGGSRVSRADVTE"
gene complement(2310913..2312517)
/locus_tag="Rv2052c"
CDS complement(2310913..2312517)
/codon_start=1
/transl_table=11
/locus_tag="Rv2052c"
/product="Conserved protein"
/note="Rv2052c, (MTV018.39c), len: 534 aa. Conserved
protein, similar to many. Contains IPR013108
Amidohydrolase 3 domain."
/db_xref="EnsemblGenomes-Gn:Rv2052c"
/db_xref="EnsemblGenomes-Tr:CCP44825"
/db_xref="GOA:O53494"
/db_xref="InterPro:IPR011059"
/db_xref="InterPro:IPR013108"
/db_xref="InterPro:IPR032466"
/db_xref="InterPro:IPR033932"
/db_xref="UniProtKB/TrEMBL:O53494"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44825.1"
/translation="MSQIPVKLLVNGRVYSPTHPEATAMAVRGDVVAWLGSDDVGRDQ
FPDADVQDLDGRFVAPGFVDSHIHLTATGLMLSGLDLRPATSRAQCLRMVADYAADHP
GQPLWGHGWDESAWPENAAPSTADLDAVLGDCPAYLARIDSHSALVSSGLRRLVPELA
AATGYTAQRPLTGDAHHLARAAARYLLTDVQLADARAVALQAIAAAGVVAVHECAGPE
IGGLDDWLRLRALEHGVEVIGYWGEAVATPAQARDLVTETGARGLAGDLFVDGALGSR
TAWLHEPYADAPDCIGTCHLDVDGIEAHVRACTKAEVTAGFHVIGDAAVSAAVAAFER
VVADLGVVAVARCGHRLEHVEMVTADQAAKLGAWGVIASVQPNFDELWGGGDGMYARR
LGAQRGSELNPLALLASQGVPLALGSDAPVTGFDPWASVRAAVNHRTPGSGVSARAAF
AAATRGGWRAGGVRDGRIGTLVPGAPASYAIWDAGDFDVDAPRDAVQRWSTDPRSRVP
ALPRLGPTDALPRCRQTVHRGAVIYG"
gene complement(2312522..2313049)
/gene="fxsA"
/locus_tag="Rv2053c"
CDS complement(2312522..2313049)
/codon_start=1
/transl_table=11
/gene="fxsA"
/locus_tag="Rv2053c"
/product="Probable transmembrane protein FxsA"
/note="Rv2053c, (MTV018.40c-MTCY63A.07), len: 175 aa.
Probable fxsA, transmembrane protein. Contains IPR007313
FxsA cytoplasmic membrane protein domain in N-terminus"
/db_xref="EnsemblGenomes-Gn:Rv2053c"
/db_xref="EnsemblGenomes-Tr:CCP44826"
/db_xref="GOA:O53495"
/db_xref="InterPro:IPR007313"
/db_xref="UniProtKB/TrEMBL:O53495"
/protein_id="CCP44826.1"
/translation="MSRLLLSYAVVELAVVFALAATIGFGWTLLVLLATFVLGFGLLA
PLGGWQLGRRLLWLRSGLAEPRSALSDGALVTVASVLVLVPGLVTTTMGLLLLVPPIR
ALARPGLTAIAVRGFLRNVPLTADAAANMAGAFGESGTDPDFIDGEVIDVIDVEPLTL
QPPRVAAEPPSPGSN"
gene 2313125..2313838
/locus_tag="Rv2054"
CDS 2313125..2313838
/codon_start=1
/transl_table=11
/locus_tag="Rv2054"
/product="Conserved protein"
/note="Rv2054, (MTCY63A.06c), len: 237 aa. Conserved
protein, similar to many. Contains IPR002925 Dienelactone
hydrolase domain."
/db_xref="EnsemblGenomes-Gn:Rv2054"
/db_xref="EnsemblGenomes-Tr:CCP44827"
/db_xref="GOA:O86353"
/db_xref="InterPro:IPR002925"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O86353"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44827.1"
/translation="MTTIEIDAPAGPIDALLGLPPGQGPWPGVVVVHDAVGYVPDNKL
ISERIARAGYVVLTPNMYARGGRARCITRVFRELLTKRGRALDDILAARDHLLAMPEC
SGRVGIVGFCMGGQFALVLSPRGFGATAPFYGTPLPRHLSETLNGACPIVASFGTRDP
LGIGAANRLRKVTAAKNIPADIKSYPGAGHSFANKLPGQPLVRIAGFGYNEAATEDAW
RRVFEFFGQHLRAGSPGEP"
gene complement(2314087..2314353)
/gene="rpsR2"
/locus_tag="Rv2055c"
CDS complement(2314087..2314353)
/codon_start=1
/transl_table=11
/gene="rpsR2"
/locus_tag="Rv2055c"
/product="30S ribosomal protein S18 RpsR2"
/note="Rv2055c, (MTCY63A.05), len: 88 aa. rpsR2, 30S
ribosomal protein S18, similar to many. Also similar to
rpsR|Rv0055|MTCY21D4.18 from Mycobacterium tuberculosis
(50.0% identity in 84 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2055c"
/db_xref="EnsemblGenomes-Tr:CCP44828"
/db_xref="GOA:P9WH47"
/db_xref="InterPro:IPR001648"
/db_xref="InterPro:IPR018275"
/db_xref="InterPro:IPR036870"
/db_xref="UniProtKB/Swiss-Prot:P9WH47"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44828.1"
/translation="MAAKSARKGPTKAKKNLLDSLGVESVDYKDTATLRVFISDRGKI
RSRGVTGLTVQQQRQVAQAIKNAREMALLPYPGQDRQRRAALCP"
gene complement(2314354..2314659)
/gene="rpsN2"
/locus_tag="Rv2056c"
CDS complement(2314354..2314659)
/codon_start=1
/transl_table=11
/gene="rpsN2"
/locus_tag="Rv2056c"
/product="30S ribosomal protein S14 RpsN2"
/note="Rv2056c, (MTCY63A.04), len: 101 aa. rpsN2, 30S
ribosomal protein S14, similar to many. Also similar to
rpsN|Rv0717|MTCY210.36 from Mycobacterium
tuberculosis,(50.0% identity in 62 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2056c"
/db_xref="EnsemblGenomes-Tr:CCP44829"
/db_xref="GOA:P9WH59"
/db_xref="InterPro:IPR001209"
/db_xref="InterPro:IPR023036"
/db_xref="UniProtKB/Swiss-Prot:P9WH59"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44829.1"
/translation="MAKKSKIVKNQRRAATVARYASRRTALKDIIRSPSSAPEQRSTA
QRALARQPRDASPVRLRNRDAIDGRPRGHLRKFGLSRVRVRQLAHDGHLPGVRKASW"
gene complement(2314661..2314825)
/gene="rpmG1"
/gene_synonym="rpmG"
/locus_tag="Rv2057c"
CDS complement(2314661..2314825)
/codon_start=1
/transl_table=11
/gene="rpmG1"
/gene_synonym="rpmG"
/locus_tag="Rv2057c"
/product="50S ribosomal protein L33 RpmG1"
/note="Rv2057c, (MTCY63A.03), len: 54 aa. rpmG1, 50S
ribosomal protein L33, similar to many. Note that
previously known as rpmG."
/db_xref="EnsemblGenomes-Gn:Rv2057c"
/db_xref="EnsemblGenomes-Tr:CCP44830"
/db_xref="GOA:P9WH97"
/db_xref="InterPro:IPR001705"
/db_xref="InterPro:IPR011332"
/db_xref="InterPro:IPR018264"
/db_xref="InterPro:IPR038584"
/db_xref="UniProtKB/Swiss-Prot:P9WH97"
/protein_id="CCP44830.1"
/translation="MARTDIRPIVKLRSTAGTGYTYTTRKNRRNDPDRLILRKYDPIL
RRHVDFREER"
gene complement(2314825..2315061)
/gene="rpmB2"
/locus_tag="Rv2058c"
CDS complement(2314825..2315061)
/codon_start=1
/transl_table=11
/gene="rpmB2"
/locus_tag="Rv2058c"
/product="50S ribosomal protein L28 RpmB2"
/note="Rv2058c, (MTCY63A.02), len: 78 aa. rpmB2, 50S
ribosomal protein L28, very similar to rL28 of M.
tuberculosis. Also similar to rpmB (Rv0105c) of
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv2058c"
/db_xref="EnsemblGenomes-Tr:CCP44831"
/db_xref="GOA:P9WHA9"
/db_xref="InterPro:IPR001383"
/db_xref="InterPro:IPR026569"
/db_xref="InterPro:IPR034704"
/db_xref="InterPro:IPR037147"
/db_xref="UniProtKB/Swiss-Prot:P9WHA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44831.1"
/translation="MSAHCQVTGRKPGFGNTVSHSHRRSRRRWSPNIQQRTYYLPSEG
RRIRLRVSTKGIKVIDRDGIEAVVARLRRQGQRI"
gene 2315174..2316709
/locus_tag="Rv2059"
CDS 2315174..2316709
/codon_start=1
/transl_table=11
/locus_tag="Rv2059"
/product="Conserved hypothetical protein"
/note="Rv2059, (MTCY63A.01c), len: 511 aa. Conserved
hypothetical protein. Some similarity to EWLA protein
gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k
(304 aa), FASTA score, opt: 287 E(): 6.9e-09; 27.2%
identity in 228 aa overlap. There appears to be a
frameshift in this ORF around position 3315980 that causes
an overlap with next ORF. C-terminal end of protein may be
wrong. No error can be found to account for this."
/db_xref="EnsemblGenomes-Gn:Rv2059"
/db_xref="EnsemblGenomes-Tr:CCP44832"
/db_xref="GOA:O07257"
/db_xref="InterPro:IPR006127"
/db_xref="UniProtKB/TrEMBL:O07257"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44832.1"
/translation="MATPVILVTGHEGTAAVTADLLGLLTDHGTATLRSVAPGSVRRA
DPRPRCHRREQRRRHRASMKSAIHPDHHPRRLPRCPVLRRDQVVLEMIVITMVGRPSG
PGERKWDVWGSVARAVTGGHVPVKSILTGAHADPHSYQASPADAAAIVDAELVIYNGG
GYDPWVDQVLAGHPGVQAVDAYSLLGAVGDDDAPNEHVFYDPNVAKAVAATIADRLAD
LDPSNSGNYRANAAEFSRGADAIAISEHAIATTYPDAAVIATEPVVHYLLAAAGLKNR
TPATFIAANENGNDPTPADMAAVLDMIAGREVAALLVNPQTPTAATDELQVAARRAGV
PITELTETLPSGTDRDQFCAADRPDRRGRSLRADHADRGLSARGHRVGDLLPTALVCH
RRSGGRGRPRRASARPGNCVRRTDGRGSRPGCPDRRGTPRDVFADHPRRGGRPGRGCP
GRRDRDLGGLRRGFRRRRHPAVAGAWSPGVGVRGHHLVCDLPDLLVAPAAPLTSRSRF
RPL"
gene 2316279..2316680
/locus_tag="Rv2060"
CDS 2316279..2316680
/codon_start=1
/transl_table=11
/locus_tag="Rv2060"
/product="Possible conserved integral membrane protein"
/note="Rv2060, (MTV019.01), len: 133 aa. Possible
conserved integral membrane protein smaller than but
similar to several hypothetical bacterial proteins e.g.
>emb|CAC29843.1| (AL583918) putative ABC-transporter
transmembrane protein [Mycobacterium leprae] Length = 286
and P44691|YEBI_HAEIN (261 aa). FASTA scores:
P44691|YEBI_HAEIN hypothetical protein HI0407 (261 aa)
opt: 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap.
Maybe frameshift upstream at position 3315980 but no error
can be found to account for this."
/db_xref="EnsemblGenomes-Gn:Rv2060"
/db_xref="EnsemblGenomes-Tr:CCP44833"
/db_xref="GOA:O86339"
/db_xref="InterPro:IPR001626"
/db_xref="InterPro:IPR037294"
/db_xref="UniProtKB/TrEMBL:O86339"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44833.1"
/translation="MLTVVCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVF
AALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAIATSVVFAEVSAVGGIL
LSLAPGVPVSVFVATISFVIYLICWLLRRRR"
gene complement(2316681..2317085)
/locus_tag="Rv2061c"
CDS complement(2316681..2317085)
/codon_start=1
/transl_table=11
/locus_tag="Rv2061c"
/product="Conserved protein"
/note="Rv2061c, (MTV019.02c), len: 134 aa. Conserved
protein. Similar to many. Contains IPR019965
F420-dependent enzyme, PPOX class, family Rv2061, domain.
A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2061c"
/db_xref="EnsemblGenomes-Tr:CCP44834"
/db_xref="GOA:O86340"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR019965"
/db_xref="UniProtKB/TrEMBL:O86340"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44834.1"
/translation="MTPTFSDLAEAQYLLLTTFTKDGRPKPVPIWAALDTDRGDRLLV
ITEKKSWKVKRIRNTPRVTLATCTLRGRPTSEAVEATAAILDESQTGAVYDAIVKRYG
IQGKLFTFVSKLRGGMRNNIGLELKVAESETG"
gene complement(2317169..2320753)
/gene="cobN"
/locus_tag="Rv2062c"
CDS complement(2317169..2320753)
/codon_start=1
/transl_table=11
/gene="cobN"
/locus_tag="Rv2062c"
/product="Cobalamin biosynthesis protein CobN"
/note="Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa.
cobN, cobalamin biosynthesis protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2062c"
/db_xref="EnsemblGenomes-Tr:CCP44835"
/db_xref="GOA:O53498"
/db_xref="InterPro:IPR003672"
/db_xref="InterPro:IPR011953"
/db_xref="UniProtKB/TrEMBL:O53498"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44835.1"
/translation="MPEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLA
EASIVVIRILGGYRAWQSGIDTVIAGGVPAVLVSGEQAADAELTDRSTVAAGTALQAH
IYLAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGVLERPDAGKTGPTIAVLYY
RAQHLAGNTGYVEALCRAIEDAGGRPLPLYCASLRTAEPRLLERLGGADAMVVTVLAA
GGVKPAAASAGGDDDSWNVEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQV
AVPEFDGRIITVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRQVAPADKRVA
LVFSAYPTKHARIGNAVGLDTPASAVALLQAMRQRGYRVGDLPGVESNDGDALIHALI
ECGGHDPDWLTEGQLAGNPIRVSAKEYRDWFATLPAELTDVVTAYWGPPPGELFVDRS
HDPDGEIVIAALRAGNLVLMVQPPRGFGENPVAIYHDPDLPPSHHYLAAYRWLDTGFS
NGFGAHAVVHLGKHGNLEWLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGEGTQAK
RRAHAVLVDHLIPPMARAETYGDIARLEQLLDEHASVAALDPGKLPAIRQQIWTLIRA
AKMDHDLGLTERPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQNPTGEQELDLVL
AILRARQLFGGAHAIPGLRQALGLAEDGTDERATVDQTEAKARELVAALQATGWDPSA
ADRLTGNADAAAVLRFAATEVIPRLAGTATEIEQVLRALDGRFIPAGPSGSPLRGLVN
VLPTGRNFYSVDPKAVPSRLAWEAGVALADSLLARYRDEHGRWPRSVGLSVWGTSAMR
TAGDDIAEVLALLGVRPVWDDASRRVIDLAPMQPAELGRPRIDVTVRISGFFRDAFPH
VVTMLDDAVRLVADLDEAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYGAGLL
QLIDSRSWRDDADLAQVYTAWGGFAYGRDLDGREAIDDMNRQYRRIAVAAKNTDTREH
DIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPDAIRTRTLSEETTRVFRARVV
NPRWMAAMRRHGYKGAFEMAATVDYLFGYDATAGVMADWMYEQLTQRYVLDAQNRTFM
TESNPWALHGMAERLLEAAGRGLWAQPAPETLDGLRQVLLETEGDLEA"
gene 2320831..2321064
/gene="mazE7"
/locus_tag="Rv2063"
CDS 2320831..2321064
/codon_start=1
/transl_table=11
/gene="mazE7"
/locus_tag="Rv2063"
/product="Antitoxin MazE7"
/note="Rv2063, len: 77 aa. MazE7, antitoxin, part of
toxin-antitoxin (TA) operon with Rv2063A (See Pandey and
Gerdes, 2005), similar to many. This ORF replaces previous
Rv2063c on other strand."
/db_xref="EnsemblGenomes-Gn:Rv2063"
/db_xref="EnsemblGenomes-Tr:CCP44836"
/db_xref="GOA:P9WJ85"
/db_xref="PDB:6A6X"
/db_xref="UniProtKB/Swiss-Prot:P9WJ85"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44836.1"
/translation="MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAI
FRAEREASHAETTTQAVRDEDREWEGTVGDGLG"
gene 2321057..2321467
/gene="mazF7"
/locus_tag="Rv2063A"
CDS 2321057..2321467
/codon_start=1
/transl_table=11
/gene="mazF7"
/locus_tag="Rv2063A"
/product="Possible toxin MazF7"
/note="Rv2063A, len: 136 aa. Possible mazF7 toxin, part of
toxin-antitoxin (TA) operon with Rv2063 (See Pandey and
Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2063A"
/db_xref="EnsemblGenomes-Tr:CCP44837"
/db_xref="GOA:P0CL62"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="PDB:5WYG"
/db_xref="PDB:6A6X"
/db_xref="UniProtKB/Swiss-Prot:P0CL62"
/protein_id="CCP44837.1"
/translation="MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDEL
VVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGVRAVARARLVERLGALKPATMRA
IENALTLILGLPTGPERGEAATHSPVRWTGGRDP"
gene 2321451..2322542
/gene="cobG"
/locus_tag="Rv2064"
CDS 2321451..2322542
/codon_start=1
/transl_table=11
/gene="cobG"
/locus_tag="Rv2064"
/product="Precorrin-3B synthase CobG"
/note="Rv2064, (MTCY49.03), len: 363 aa. CobG,
precorrin-3B synthase, cobalamin biosynthesis protein."
/db_xref="EnsemblGenomes-Gn:Rv2064"
/db_xref="EnsemblGenomes-Tr:CCP44838"
/db_xref="GOA:Q10675"
/db_xref="InterPro:IPR005117"
/db_xref="InterPro:IPR012798"
/db_xref="InterPro:IPR036136"
/db_xref="UniProtKB/TrEMBL:Q10675"
/inference="protein motif:PROSITE:PS01156"
/protein_id="CCP44838.1"
/translation="MAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLAS
VASDFGSATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLSGR
AGGLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGADVGVQVFPDGP
RLLLTGRDTGVRVADVAETLIEVALRFVKIRETAWRVTELADIGELQSGVELGPSVRP
VTKTPVGWIPQDDSRVTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDA
TADAALRVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAGHRH
FVGCERACGSPPAGEVLVATGGGYRRLRP"
gene 2322552..2323178
/gene="cobH"
/locus_tag="Rv2065"
CDS 2322552..2323178
/codon_start=1
/transl_table=11
/gene="cobH"
/locus_tag="Rv2065"
/product="Precorrin-8X methylmutase CobH (aka precorrin
isomerase)"
/note="Rv2065, (MTCY49.04), len: 208 aa. CobH,
precorrin-8X methylmutase (aka precorrin isomerase),
similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2065"
/db_xref="EnsemblGenomes-Tr:CCP44839"
/db_xref="GOA:P9WP87"
/db_xref="InterPro:IPR003722"
/db_xref="InterPro:IPR036588"
/db_xref="UniProtKB/Swiss-Prot:P9WP87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44839.1"
/translation="MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCG
QVDVAEHVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVADPR
ATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEGAPPPAAVLGG
PVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE"
gene 2323175..2324701
/gene="cobI"
/locus_tag="Rv2066"
CDS 2323175..2324701
/codon_start=1
/transl_table=11
/gene="cobI"
/locus_tag="Rv2066"
/product="Probable bifunctional protein, CobI-COBJ fusion
protein: S-adenosyl-L-methionine-precorrin-2 methyl
transferase + precorrin-3 methylase"
/note="Rv2066, (MTCY49.05), len: 508 aa. Probable
CobI-CobJ fusion protein,
S-adenosyl-L-methionine-precorrin-2 methyl transferase and
precorrin-3 methylase. Similar in N-terminal half (aa
1-240) to many S-adenosyl-L-methionine-precorrin-2 methyl
transferase (244 aa), and in C-terminal half (aa 240-508)
to precorrin-3 methylase (254 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2066"
/db_xref="EnsemblGenomes-Tr:CCP44840"
/db_xref="GOA:P9WGB3"
/db_xref="InterPro:IPR000878"
/db_xref="InterPro:IPR003043"
/db_xref="InterPro:IPR006363"
/db_xref="InterPro:IPR006364"
/db_xref="InterPro:IPR012382"
/db_xref="InterPro:IPR014776"
/db_xref="InterPro:IPR014777"
/db_xref="InterPro:IPR035996"
/db_xref="UniProtKB/Swiss-Prot:P9WGB3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44840.1"
/translation="MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHS
IARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRN
VALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVL
PGTLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVL
PAADVDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDL
IGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMAT
AVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLT
AAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVR
VVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD
"
gene complement(2324647..2325870)
/locus_tag="Rv2067c"
CDS complement(2324647..2325870)
/codon_start=1
/transl_table=11
/locus_tag="Rv2067c"
/product="Conserved protein"
/note="Rv2067c, (MTCY49.06c), len: 407 aa. Conserved
protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2067c"
/db_xref="EnsemblGenomes-Tr:CCP44841"
/db_xref="GOA:P9WLL9"
/db_xref="InterPro:IPR025714"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WLL9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44841.1"
/translation="MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSH
RILWPDREYRPDLDILIAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHG
LANLELHLLPIEELATLGRDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLY
GKYGRIGVELLGSVFRDLGLGQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSA
LVDTFLHGRQRSYTVEECVDLVTSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLP
EVKAWSVMERLETLNATHLFMACRRDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTD
MFWPGWRMAPSPAQLAFLQQVDGRRTIREIAGCVARTGEPSGGSLADLEEFGRKLFQS
LWRLDFVAVALPASG"
gene complement(2325886..2326809)
/gene="blaC"
/locus_tag="Rv2068c"
CDS complement(2325886..2326809)
/codon_start=1
/transl_table=11
/gene="blaC"
/locus_tag="Rv2068c"
/product="Class a beta-lactamase BlaC"
/note="Rv2068c, (MTCY49.07c), len: 307 aa. BlaC, class a
beta-lactamase (see citation below), similar to many.
Contains PS00013 Prokaryotic lipid attachment site near
N-terminus, and PS00146 Beta-lactamase class-a active
site."
/db_xref="EnsemblGenomes-Gn:Rv2068c"
/db_xref="EnsemblGenomes-Tr:CCP44842"
/db_xref="GOA:P9WKD3"
/db_xref="InterPro:IPR000871"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR023650"
/db_xref="PDB:2GDN"
/db_xref="PDB:3CG5"
/db_xref="PDB:3DWZ"
/db_xref="PDB:3IQA"
/db_xref="PDB:3M6B"
/db_xref="PDB:3M6H"
/db_xref="PDB:3N6I"
/db_xref="PDB:3N7W"
/db_xref="PDB:3N8L"
/db_xref="PDB:3N8R"
/db_xref="PDB:3N8S"
/db_xref="PDB:3NBL"
/db_xref="PDB:3NC8"
/db_xref="PDB:3NCK"
/db_xref="PDB:3NDE"
/db_xref="PDB:3NDG"
/db_xref="PDB:3NY4"
/db_xref="PDB:3VFF"
/db_xref="PDB:3VFH"
/db_xref="PDB:3ZHH"
/db_xref="PDB:4DF6"
/db_xref="PDB:4EBL"
/db_xref="PDB:4EBN"
/db_xref="PDB:4EBP"
/db_xref="PDB:4JLF"
/db_xref="PDB:4Q8I"
/db_xref="PDB:4QB8"
/db_xref="PDB:4QHC"
/db_xref="PDB:4X6T"
/db_xref="PDB:5NJ2"
/db_xref="PDB:5OYO"
/db_xref="PDB:6B5X"
/db_xref="PDB:6B5Y"
/db_xref="PDB:6B68"
/db_xref="PDB:6B69"
/db_xref="PDB:6B6A"
/db_xref="PDB:6B6B"
/db_xref="PDB:6B6C"
/db_xref="PDB:6B6D"
/db_xref="PDB:6B6E"
/db_xref="PDB:6B6F"
/db_xref="UniProtKB/Swiss-Prot:P9WKD3"
/inference="protein motif:PROSITE:PS00146"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44842.1"
/translation="MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADL
ADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTH
LDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGG
TAAFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPD
KRALLTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVA
VMSDRAGGGYDAEPREALLAEAATCVAGVLA"
gene 2326944..2327501
/gene="sigC"
/locus_tag="Rv2069"
CDS 2326944..2327501
/codon_start=1
/transl_table=11
/gene="sigC"
/locus_tag="Rv2069"
/product="RNA polymerase sigma factor, ECF subfamily,
SigC"
/note="Rv2069, (MTCY49.08), len: 185 aa. SigC, RNA
polymerase sigma factor, ECF subfamily (see Gomez et
al.,1997; Chen et al., 2000), similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2069"
/db_xref="EnsemblGenomes-Tr:CCP44843"
/db_xref="GOA:P9WGH1"
/db_xref="InterPro:IPR000838"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039425"
/db_xref="PDB:2O7G"
/db_xref="PDB:2O8X"
/db_xref="UniProtKB/Swiss-Prot:P9WGH1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44843.1"
/translation="MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYL
SDVGSADDLTQETFLRAIGAIPRFSARSSARTWLLAIARHVVADHIRHVRSRPRTTRG
ARPEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPV
GTIRSRVARARDALLADAEPDDLTG"
gene complement(2327491..2328225)
/gene="cobK"
/locus_tag="Rv2070c"
CDS complement(2327491..2328225)
/codon_start=1
/transl_table=11
/gene="cobK"
/locus_tag="Rv2070c"
/product="Precorrin-6X reductase CobK"
/note="Rv2070c, (MTCY49.09c), len: 244 aa.
CobK,precorrin-6x reductase, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2070c"
/db_xref="EnsemblGenomes-Tr:CCP44844"
/db_xref="GOA:P9WP89"
/db_xref="InterPro:IPR003723"
/db_xref="UniProtKB/Swiss-Prot:P9WP89"
/protein_id="CCP44844.1"
/translation="MTRVLLLGGTAEGRALAKELHPHVEIVSSLAGRVPNPALPIGPV
RIGGFGGVEGLRGWLREERIDAVVDATHPFAVTITAHAAQVCGELGLPYLVLARPPWD
PGTAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFANSDAWFLIRVVTAPDGTALP
RRHKLVLSRGPYGYHDEFALLREQRIDALVTKNSGGKMTRAKLDAAAALGISVVMIAR
PLLPAGVAAVDSVHRAAMWVAGLPSR"
gene complement(2328222..2328977)
/gene="cobM"
/locus_tag="Rv2071c"
CDS complement(2328222..2328977)
/codon_start=1
/transl_table=11
/gene="cobM"
/locus_tag="Rv2071c"
/product="Precorrin-3 methylase CobM (precorrin-4
C11-methyltransferase)"
/note="Rv2071c, (MTCY49.10c), len: 251 aa.
CobM,precorrin-3 methylase, similar to many. Contains
PS00839 Uroporphyrin-III C-methyltransferase signature 1,
and PS00840 Uroporphyrin-III C-methyltransferase signature
2."
/db_xref="EnsemblGenomes-Gn:Rv2071c"
/db_xref="EnsemblGenomes-Tr:CCP44845"
/db_xref="GOA:P9WGB1"
/db_xref="InterPro:IPR000878"
/db_xref="InterPro:IPR003043"
/db_xref="InterPro:IPR006362"
/db_xref="InterPro:IPR014776"
/db_xref="InterPro:IPR014777"
/db_xref="InterPro:IPR035996"
/db_xref="UniProtKB/Swiss-Prot:P9WGB1"
/inference="protein motif:PROSITE:PS00840"
/inference="protein motif:PROSITE:PS00839"
/protein_id="CCP44845.1"
/translation="MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQ
CPPGATIVDTGPLTLEQIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGI
GYEIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRAT
LVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKI
TRTAVIVVGDVLTAEGFTDSYLYSVARHGRYAQ"
gene complement(2328974..2330146)
/gene="cobL"
/locus_tag="Rv2072c"
CDS complement(2328974..2330146)
/codon_start=1
/transl_table=11
/gene="cobL"
/locus_tag="Rv2072c"
/product="Precorrin-6Y C(5,15)-methyltransferase
(decarboxylating) CobL"
/note="Rv2072c, (MTCY49.11c), len: 390 aa.
CobL,precorrin-6Y C(5,15)-methyltransferase
(decarboxylating)."
/db_xref="EnsemblGenomes-Gn:Rv2072c"
/db_xref="EnsemblGenomes-Tr:CCP44846"
/db_xref="GOA:P9WGA9"
/db_xref="InterPro:IPR000878"
/db_xref="InterPro:IPR006365"
/db_xref="InterPro:IPR012818"
/db_xref="InterPro:IPR014008"
/db_xref="InterPro:IPR014777"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR035996"
/db_xref="UniProtKB/Swiss-Prot:P9WGA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44846.1"
/translation="MIIVVGIGADGMTGLSEHSRSELRRATVIYGSKRQLALLDDTVT
AERWEWPTPMLPAVQGLSPDGADLHVVASGDPLLHGIGSTLIRLFGHDNVTVLPHVSA
VTLACARMGWNVYDTEVISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRG
DSKFSVLEQLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLLDERTSWAPDEAFA
HDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSWPGCTAVAFERDERR
RRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFLGGGVTQPGLLEACLDSLPAGGN
LVANAVTVESEAALAHAYSRLGGELRRFQHYLGEPLGGFTGWRPQLPVTQWSVTKR"
repeat_region complement(2330147..2330225)
/note="79 bp Mycobacterial Interspersed Repetitive
Unit,Class I"
gene complement(2330214..2330963)
/locus_tag="Rv2073c"
CDS complement(2330214..2330963)
/codon_start=1
/transl_table=11
/locus_tag="Rv2073c"
/product="Probable shortchain dehydrogenase"
/note="Rv2073c, (MTCY49.12c), len: 249 aa. Probable
oxidoreductase, belonging to shortchain dehydrogenase
reductase (SDR) family, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2073c"
/db_xref="EnsemblGenomes-Tr:CCP44847"
/db_xref="GOA:P9WGR3"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGR3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44847.1"
/translation="MDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLAD
QAAALRAAGAIAVHTREFDADDLAAHGPLVASLVAEHGPIGTAVLAFGILGDQARAET
DAAHAVAIVHTDYVAQVSLLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKA
GLDGFASGLADALHGTGVRLLIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVN
GKRVVWIPWALRPMFVALRLLPRFVWRRMPR"
gene 2330993..2331406
/locus_tag="Rv2074"
CDS 2330993..2331406
/codon_start=1
/transl_table=11
/locus_tag="Rv2074"
/product="Possible pyridoxamine 5'-phosphate oxidase
(PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX)
(pyridoxine 5'-phosphate oxidase)"
/note="Rv2074, (MTCY49.13), len: 137 aa. Possible
pyridoxine 5'-phosphate oxidase (PNPOx) (See Biswal et
al.,2006). Similar to conserved hypothetical proteins."
/db_xref="EnsemblGenomes-Gn:Rv2074"
/db_xref="EnsemblGenomes-Tr:CCP44848"
/db_xref="GOA:P9WLL7"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR019920"
/db_xref="PDB:2ASF"
/db_xref="PDB:5JAB"
/db_xref="UniProtKB/Swiss-Prot:P9WLL7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44848.1"
/translation="MAMVNTTTRLSDDALAFLSERHLAMLTTLRADNSPHVVAVGFTF
DPKTHIARVITTGGSQKAVNADRSGLAVLSQVDGARWLSLEGRAAVNSDIDAVRDAEL
RYAQRYRTPRPNPRRVVIEVQIERVLGSADLLDRA"
gene complement(2331416..2332879)
/locus_tag="Rv2075c"
CDS complement(2331416..2332879)
/codon_start=1
/transl_table=11
/locus_tag="Rv2075c"
/product="Possible hypothetical exported or envelope
protein"
/note="Rv2075c, (MTCY49.14c), len: 487 aa. Possibly
exported or envelope protein; has potential signal peptide
at N-terminus and hydrophobic stretch around residue 430.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv2075c"
/db_xref="EnsemblGenomes-Tr:CCP44849"
/db_xref="GOA:P9WLL5"
/db_xref="InterPro:IPR016187"
/db_xref="InterPro:IPR017946"
/db_xref="UniProtKB/Swiss-Prot:P9WLL5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44849.1"
/translation="MPRARWLQSAALMGALAVVLITAAPVAADAYQVPAPPSPTASCD
VISPVAIPCVALGKFADAVAAECRRVGVPDARCVLPLAHRVTQAARDAYLQSWVHRTA
RFQDALQDPVPLRETQWLGTHNSFNSLSDSFTVSHADSNQQLSLAQQLDIDVRALELD
LHYLPRLEGHGAPGVTVCHGLGPKNANLGCTVEPLLATVLPQIANWLNAPGHTEEVIL
LYLEDQLKNASAYESVVATLDQVLRRADGTSLIYRPNPARRATNGCVPLPLDVSREEI
RASGARAVLVGSCAPGWSAAVFDWSGVELESGSNSGYRPYPACDATYGRGVYAWRLVR
YYEDSTLATALANPTRPPANPQALTPPKVPAMTDCGVNLFGFDQLLPEDGRIQASLWS
WAPDEPRAGAGACALQGADGRWVAASCGDPHPAACRDAAGRWTVTPAPVVFAGAALAC
TAIGADFTLPRTGNQNARLHAVAGPAGGAWVHYLLPP"
gene complement(2333037..2333288)
/locus_tag="Rv2076c"
CDS complement(2333037..2333288)
/codon_start=1
/transl_table=11
/locus_tag="Rv2076c"
/product="Conserved hypothetical protein"
/note="Rv2076c, (MTCY49.15c), len: 83 aa. Conserved
hypothetical protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2076c"
/db_xref="EnsemblGenomes-Tr:CCP44850"
/db_xref="GOA:P9WLL3"
/db_xref="UniProtKB/Swiss-Prot:P9WLL3"
/protein_id="CCP44850.1"
/translation="MVVCLIGGVAGSLWPRPAGRLRGGCYFAFMGVAWVLLAISAIAN
AVKGSLWWDIWSLGLLVLIPAVVYGKMRRSRRISSDQDR"
gene complement(2333323..2334294)
/locus_tag="Rv2077c"
CDS complement(2333323..2334294)
/codon_start=1
/transl_table=11
/locus_tag="Rv2077c"
/product="Possible conserved transmembrane protein"
/note="Rv2077c, (MTCY49.16c), len: 323 aa. Possible
conserved transmembrane protein. Part of Mycobacterium
tuberculosis protein family with Rv2542, Rv2079,
Rv2797c,Rv0963c, Rv1949c. Hydrophobic stretches at
C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv2077c"
/db_xref="EnsemblGenomes-Tr:CCP44851"
/db_xref="GOA:P9WLL1"
/db_xref="UniProtKB/Swiss-Prot:P9WLL1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44851.1"
/translation="MLATLSQIRAWSTEHLIDAAGYWTETADRWEDVFLQMRNQAHAI
AWNGAGGDGLRQRTRADFSTVSGIADQLRRAATIARNGAGTIDAAQRRVMYAVEDAQD
AGFNVGEDLSVTDTKTTQPAAVQAARLAQAQALAGDIRLRVGQLVAAENEVSGQLAAT
TGDVGNVRFAGAPVVAHSAVQLVDFFKQDGPTPPPPGAPHPSGGADGPYSDPITSMML
PPAGTEAPVSDATKRWVDNMVNELAARPPDDPIAVEARRLAFQALHRPCNSAEWTAAV
AGFAGSSAGVVGTALAIPAGPADWALLGAALLGVGGSGAAVVNCATK"
gene complement(2334295..2334594)
/locus_tag="Rv2077A"
CDS complement(2334295..2334594)
/codon_start=1
/transl_table=11
/locus_tag="Rv2077A"
/product="Conserved hypothetical protein"
/note="Rv2077A, len: 99 aa. Conserved hypothetical
protein,similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2077A"
/db_xref="EnsemblGenomes-Tr:CCP44852"
/db_xref="UniProtKB/TrEMBL:L7N6B8"
/protein_id="CCP44852.1"
/translation="MGSNELQVVLGQLEVAASQSQGLGAQFAASATPPESGQPFQATT
VAVSGINAAICCAAAEFATRTQATATGVAAAAAAYAHQEATAASEMAAVTQVTVV"
gene 2335059..2335373
/locus_tag="Rv2078"
CDS 2335059..2335373
/codon_start=1
/transl_table=11
/locus_tag="Rv2078"
/product="Conserved hypothetical protein"
/note="Rv2078, (MTCY49.17), len: 104 aa. Conserved
hypothetical protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2078"
/db_xref="EnsemblGenomes-Tr:CCP44853"
/db_xref="InterPro:IPR022534"
/db_xref="UniProtKB/Swiss-Prot:P9WLK9"
/protein_id="CCP44853.1"
/translation="MFVDVELLHSGANESHYAGEHAHGGADQLSRGPLLSGMFGTFPV
AQTFHDAVGAAHAQQMRNLHAHRQALITVGEKARHAATGFTDMDDGNAAELKAVVCSC
AT"
gene 2335355..2337325
/locus_tag="Rv2079"
CDS 2335355..2337325
/codon_start=1
/transl_table=11
/locus_tag="Rv2079"
/product="Conserved hypothetical protein"
/note="Rv2079, (MTCY49.18), len: 656 aa. Conserved
hypothetical protein; part of Mycobacterium tuberculosis
protein family with Rv2542, Rv2077c, Rv2797c,
Rv0963c,Rv1949c. Contains PS00120 Lipases, serine active
site"
/db_xref="EnsemblGenomes-Gn:Rv2079"
/db_xref="EnsemblGenomes-Tr:CCP44854"
/db_xref="InterPro:IPR010427"
/db_xref="UniProtKB/Swiss-Prot:P9WLK7"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44854.1"
/translation="MQLRHINIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAA
GRYTAEANAAFEEARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGVDL
ENIAADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEHDPRLAAAERSELDALITC
LEQDAIDDTASALGQLQSIRAGYSDHLQQSLAMLRADGYDGAGLQGLDAPQSPVKPEE
PIQIPPPGTGAPEVHRWWTSLTSEERQRLIAEHPEQIGNLNGVPVSARSDANIAVMTR
DLNRVRDIATRYRTSVDDVLGDPAKYGLSAGDITRYRNADETKKGLDHNARNDPRNPS
PVYLFAYDPMAFGGKGRAAIAIGNPDTAKHTAVIVPGTSSSVKGGWLHDNHDDALNLF
NQAKAADPNNPTAVIAWMGYDAPNDFTDPRIATPMLARIGGAALAEDVNGLWVTHLGV
GQNVTVLGHSYGSTTVADAFALGGMHANDAVLLGCPGTDLAHSAASFHLDGGRVYVGA
ASTDPISMLGQLDSLSQYVNRGNLAGQLQGLAVGLGTDPAGDGFGSVRFRAEVPNSDG
INPHDHSYYYHRGSEALRSMADIASGHGDALASDGMLAQPRHQPGVEIDIPGLGSVEI
DIPGTPASIDPEWSRPPGSITDDHVFDAPLHR"
gene 2337306..2337869
/gene="lppJ"
/locus_tag="Rv2080"
CDS 2337306..2337869
/codon_start=1
/transl_table=11
/gene="lppJ"
/locus_tag="Rv2080"
/product="Lipoprotein LppJ"
/note="Rv2080, (MTCY49.19), len: 187 aa. LppJ,
lipoprotein; contains prokayotic lipoprotein modification
site (PS00013) and signal sequence at N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv2080"
/db_xref="EnsemblGenomes-Tr:CCP44855"
/db_xref="GOA:P9WK77"
/db_xref="UniProtKB/Swiss-Prot:P9WK77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44855.1"
/translation="MPHSTADRRLRLTRQALLAAAVVPLLAGCALVMHKPHSAGSSNP
WDDSAHPLTDDQAMAQVVEPAKQIVAAADLQAVRAGFSFTSCNDQGDPPYQGTVRMAF
LLQGDHDAYFQHVRAAMLSHGWIDGPPPGQYFHGITLHKNGVTANMSLALDHSYGEMI
LDGECRNTTDHHHDDETTNITNQLVQP"
gene complement(2338065..2338505)
/locus_tag="Rv2081c"
CDS complement(2338065..2338505)
/codon_start=1
/transl_table=11
/locus_tag="Rv2081c"
/product="Conserved transmembrane protein"
/note="Rv2081c, (MTCY49.20c), len: 146 aa. Conserved
transmembrane protein, similar to many. Hydrophobic
stretch from aa 32-54."
/db_xref="EnsemblGenomes-Gn:Rv2081c"
/db_xref="EnsemblGenomes-Tr:CCP44856"
/db_xref="GOA:P9WLK5"
/db_xref="UniProtKB/Swiss-Prot:P9WLK5"
/protein_id="CCP44856.1"
/translation="MFANAGLSPFVAIWTARAASLYTSHNFWCAAAVSAAVYVGSAVV
PAAVAGPLFVGRVSATIKAAAPSTTAAIATLATAANGQLRERGGAGGWVGVHCPVVGG
GGVGHPRKAIAAAVSVHSTCMPAAFGGHLGLGDRSRSVSLSGTP"
gene 2338709..2340874
/locus_tag="Rv2082"
CDS 2338709..2340874
/codon_start=1
/transl_table=11
/locus_tag="Rv2082"
/product="Conserved hypothetical protein"
/note="Rv2082, (MTCY49.21), len: 721 aa. Conserved
hypothetical protein. Similar to Mycobacterium
tuberculosis Rv0029, and to Rv3899c and Rv3900c which may
be frameshifted."
/db_xref="EnsemblGenomes-Gn:Rv2082"
/db_xref="EnsemblGenomes-Tr:CCP44857"
/db_xref="GOA:Q10690"
/db_xref="InterPro:IPR040604"
/db_xref="InterPro:IPR040833"
/db_xref="UniProtKB/Swiss-Prot:Q10690"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44857.1"
/translation="MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEA
NDLRNERSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYLRD
RLTEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATAMSNIIDATQR
VFDETIGGDAHTWLRDHGVSLDTPARPRPVTAEDMTSMTANSPAGSPFGAAPSAPSHS
TTTSGPPTAPTPTSPFGTAPMVLSSSSTSSGPPTAPTPTSPFGTAPMPPGPPPPGTVS
PPLPPSAPAVGVGGPSVPAAGMPPAAAAATAPLSPQSLGQSFTTGMTTGTPAAAGAQA
LSAGALHAATEPLPPPAPPPTTPTVTTPTVATATTAGIPHIPDSAPTPSPAPIAPPTT
DNASAMTPIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPTPTGPIS
GAAVTPSSPAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASATAAATTGAAAGDTSR
RAAEQQRLRRILDTVARQEPGLSWAAGLRDNGQTTLLVTDLASGWIPPHIRLPAHITL
LEPAPRRRHATVTDLLGTTTVAAAHHPHGYLSQPDPDTPALTGDRTARIAPTIDELGP
TLVETVRRHDTLPPIAQAVVVAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIA
TVVDWMLLAAINALIAGDQSGANYHLAWAIAAISTRRSR"
gene 2340871..2341815
/locus_tag="Rv2083"
CDS 2340871..2341815
/codon_start=1
/transl_table=11
/locus_tag="Rv2083"
/product="Conserved hypothetical protein"
/note="Rv2083, (MTCY49.22), len: 314 aa. Conserved
hypothetical protein. Similar to many e.g. Mycobacterium
tuberculosis Rv3898c (110 aa) and Rv3897c (210 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2083"
/db_xref="EnsemblGenomes-Tr:CCP44858"
/db_xref="GOA:P9WLK3"
/db_xref="UniProtKB/Swiss-Prot:P9WLK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44858.1"
/translation="MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFG
LSTNADLGGANADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGMAQMASGI
GGALSGALGGVMGPLTQLPQQAMQAGQGAMQPLMSAMQQAQGADGLAAVDGARLLDSI
GGEPGLGSGAGGGDVGGGGAGGTTPTGYLGPPPVPTSSPPTTPAGAPTKSATMPPPGG
ASPASAHMGAAGMPMVPPGAMGARGEGSGQEKPVEKRLTAPAVPNGQPVKGRLTVPPS
APTTKPTDGKPVVRRRILLPEHKDFGRIAPDEKTDAGE"
gene 2341808..2342944
/locus_tag="Rv2084"
CDS 2341808..2342944
/codon_start=1
/transl_table=11
/locus_tag="Rv2084"
/product="Hypothetical protein"
/note="Rv2084, (MTCY49.23), len: 378 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2084"
/db_xref="EnsemblGenomes-Tr:CCP44859"
/db_xref="GOA:P9WLK1"
/db_xref="UniProtKB/Swiss-Prot:P9WLK1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44859.1"
/translation="MSDDSSSAFDLICAEIERQLRGGELLMDAAAASELLLTVRYQLD
TQPRPLVIVHGPLFQAVKAARAQVYGRLIQLRHARCEVLDERWQLRPTGQRDVRALLI
DVLNVLLAAITAAGVERAYACAERRAMAAAVVAKNYRDALGVELQCNSVCRAAAEAIH
ALAHRTGATEDADCLPPVDVIHADVTRRMHGEVATDVVAAGELVIAARHLLDPMPRGE
LSYGPLHEGGNAARKSVYRRLVQLWQARRAVTDGDVDLRDARTLLTDLDSILREMRTA
ATIQQSGTAGDGGGGRRQDSRRRNGPRRPARRGTSRGRRCAPRVAIGWHTPIGDPLAV
EGVEEIGASLPGRESTPSDDGGSLHPSGRPRRVHRRRWCGLGLC"
mobile_element 2342942..2344410
/mobile_element_type="insertion sequence:IS1556"
/note="IS1556, len: 1469 nt. Possible Insertion
sequence-like region. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 2343027..2343332
/locus_tag="Rv2085"
CDS 2343027..2343332
/codon_start=1
/transl_table=11
/locus_tag="Rv2085"
/product="Conserved hypothetical protein"
/note="Rv2085, (MTCY49.24), len: 101 aa. Conserved
hypothetical protein, similar to but shorter than many
transposases but we can find no sequence errors to account
for the frameshifts. Contains possible helix-turn-helix
motif at aa 33 to 54,(+3.11 SD). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2085"
/db_xref="EnsemblGenomes-Tr:CCP44860"
/db_xref="UniProtKB/Swiss-Prot:P9WLJ9"
/protein_id="CCP44860.1"
/translation="MSDMCDVVSFVGAAERVLRARFRPSPESGPPVHARRCGWSLGIS
AETLRRWAGQAEVDSGVVAGVSASRSGSVKTSELEQTIEILKVATSFFARKCDPRHR"
gene 2343311..2343916
/locus_tag="Rv2086"
CDS 2343311..2343916
/codon_start=1
/transl_table=11
/locus_tag="Rv2086"
/product="Conserved hypothetical protein"
/note="Rv2086, (MTCY49.25), len: 201 aa. Conserved
hypothetical protein, similarity to but shorter than many
transposases but we can find no sequence errors to account
for the frameshifts. Start changed since first submission
(-16 aa). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2086"
/db_xref="EnsemblGenomes-Tr:CCP44861"
/db_xref="InterPro:IPR025948"
/db_xref="UniProtKB/Swiss-Prot:P64937"
/protein_id="CCP44861.1"
/translation="MRPATPLICAFGDKHKHTYGVTPICRALAVHGVQIASRTYFADR
AAAPSKRALWDTTITEILAGYYEPDAEGKRPPECLYGSLKMWAHLQRQGFRWPSATVK
TIMRANGWRGVPLAAHITHHRTRPGRGPGPRPGGSAMAGFSNEPAGSGRLHLRADDVE
FRLHRVRGRRLRRCDRGLGMLADQRRSVRRTRITPRPSRLT"
gene 2343994..2344224
/locus_tag="Rv2087"
CDS 2343994..2344224
/codon_start=1
/transl_table=11
/locus_tag="Rv2087"
/product="Conserved hypothetical protein"
/note="Rv2087, (MTCY49.27), len: 76 aa. Conserved
hypothetical protein, similar to but shorter than
transposases, but we can find no sequence errors to
account for the frameshifts. Start changed since first
submission (-45 aa). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv2087"
/db_xref="EnsemblGenomes-Tr:CCP44862"
/db_xref="UniProtKB/Swiss-Prot:P9WLJ7"
/protein_id="CCP44862.1"
/translation="MLAGLRPSIGIVGDALDNALCETTTGPHRTECSHGSPFRSGPIR
TLADLEDIASAWVEHTCHTQQGVRIPGRLQPA"
gene 2344411..2346180
/gene="pknJ"
/locus_tag="Rv2088"
CDS 2344411..2346180
/codon_start=1
/transl_table=11
/gene="pknJ"
/locus_tag="Rv2088"
/product="Transmembrane serine/threonine-protein kinase J
PknJ (protein kinase J) (STPK J)"
/note="Rv2088, (MTCY49.28), len: 589 aa.
PknJ,transmembrane serine/threonine-protein kinase (see
citation below). Contains PS00108 Serine/Threonine protein
kinases active-site signature. Contains Hank's kinase
subdomain. Belongs to the Ser/Thr family of protein
kinases. Experimental studies show evidence of
auto-phosphorylation. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007). Cofactor: requires divalent cations for activity."
/db_xref="EnsemblGenomes-Gn:Rv2088"
/db_xref="EnsemblGenomes-Tr:CCP44863"
/db_xref="GOA:P9WI67"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR026954"
/db_xref="InterPro:IPR038232"
/db_xref="UniProtKB/Swiss-Prot:P9WI67"
/inference="protein motif:PROSITE:PS00108"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44863.1"
/translation="MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKV
LAAELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRLWIAMQFVDGGNAEDA
LRAATMTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFLLSRAAGGDERVLLSDFG
IARALGDTGLTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPFAA
GAGAAVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRFTSAGEFAHAAA
AALYGGATDGWVPPSPAPHVISQGAVPGSPWWQHPVGSVTALATPPGHGWPPGLPPLP
RRPRRYRRGVAAVAAVMVVAAAAVTAVTMTSHQPRTATPPSAAALSPTSSSTTPPQPP
IVTRSRLPGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPNGSINPAECWPAVGGGVPSA
YDLGTVIGFYGLTIDEPPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTV
TLFRSEWRRPVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNNVLVDVDIMT
PDTSRGQQAVIGITNYILAKIPG"
gene complement(2346197..2347324)
/gene="pepE"
/locus_tag="Rv2089c"
CDS complement(2346197..2347324)
/codon_start=1
/transl_table=11
/gene="pepE"
/locus_tag="Rv2089c"
/product="Dipeptidase PepE"
/note="Rv2089c, (MTCY49.29c), len: 375 aa.
PepE,dipeptidase, similar to many; contains PS00491
Aminopeptidase P and proline dipeptidase signature. Also
similar to Mycobacterium tuberculosis peptidases
Rv2861c,Rv0734, Rv2535c. Phosphorylated in vitro by
PknJ|Rv2088 (See Jang et al., 2010)."
/db_xref="EnsemblGenomes-Gn:Rv2089c"
/db_xref="EnsemblGenomes-Tr:CCP44864"
/db_xref="GOA:P9WHS7"
/db_xref="InterPro:IPR000587"
/db_xref="InterPro:IPR000994"
/db_xref="InterPro:IPR001131"
/db_xref="InterPro:IPR029149"
/db_xref="InterPro:IPR036005"
/db_xref="UniProtKB/Swiss-Prot:P9WHS7"
/inference="protein motif:PROSITE:PS00491"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44864.1"
/translation="MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGS
RAETFERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGDDPYGLVSA
VLGGAPVATAVTDSMPALHMLPLADALGVLPVLATDVLRRLRMVKEETEIDALRKAGA
AIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGHSEVAFVIVGSGPHGADPHHGYSD
RELREGDIVVVDIGGTYGPGYHSDSTRTYSIGEPDSDVAQSYSMLQRAQRAAFEAIRP
GVTAEQVDAAARDVLAEAGLAEYFVHRTGHGIGLCVHEEPYIVAGNDLVLVPGMAFSI
EPGIYFPGRWGARIEDIVIVTEDGAVSVNNCPHELIVVPVS"
gene 2347373..2348554
/locus_tag="Rv2090"
CDS 2347373..2348554
/codon_start=1
/transl_table=11
/locus_tag="Rv2090"
/product="Probable 5'-3' exonuclease"
/note="Rv2090, (MTCY49.30), len: 393 aa. Probable 5'-3'
exonuclease, similar to exonuclease part of DNA
polymerase. Belongs to family a of DNA polymerases."
/db_xref="EnsemblGenomes-Gn:Rv2090"
/db_xref="EnsemblGenomes-Tr:CCP44865"
/db_xref="GOA:P9WNU3"
/db_xref="InterPro:IPR002421"
/db_xref="InterPro:IPR008918"
/db_xref="InterPro:IPR020045"
/db_xref="InterPro:IPR020046"
/db_xref="InterPro:IPR029060"
/db_xref="InterPro:IPR036279"
/db_xref="InterPro:IPR038969"
/db_xref="UniProtKB/Swiss-Prot:P9WNU3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44865.1"
/translation="MPAPDPMRGDPPHPAPPRLRSPLDPTSGDPLHPAPPRLRSPLDP
TSGDPLHPAPPRLRSPLDPTSGDPLHPAPPRLRSPLVLLDGASMWFRSFFGVPSSITA
PDGRPVNAVRGFIDSMAVVITQQRPNRLAVCLDLDWRPQFRVDLIPSYKAHRVAEPEP
NGQPDVEEVPDELTPQVDMIMELLDAFGIAMAGAPGFEADDVLGTLATRERRDPVIVV
SGDRDLLQVVADDPVPVRVLYLGRGLAKATLFGPAEVAERYGLPAHRAGAAYAELALL
RGDPSDGLPGVPGVGEKTAATLLARHGSLDQIMAAADDRKTTMAKGLRTKLLAASAYI
KAADRVVRVATDAPVTLSTPTDRFPLVAADPERTAELATRFGVESSIARLQKALDTLP
G"
gene complement(2348558..2349292)
/locus_tag="Rv2091c"
CDS complement(2348558..2349292)
/codon_start=1
/transl_table=11
/locus_tag="Rv2091c"
/product="Probable membrane protein"
/note="Rv2091c, (MTCY49.31c), len: 244 aa. Probable
membrane protein; contains potential transmembrane region.
Repetitive ORF. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2091c"
/db_xref="EnsemblGenomes-Tr:CCP44866"
/db_xref="GOA:P9WLJ5"
/db_xref="InterPro:IPR025637"
/db_xref="UniProtKB/Swiss-Prot:P9WLJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44866.1"
/translation="MSGPQGSDPRQPWQPPGQGADHSSDPTVAAGYPWQQQPTQEATW
QAPAYTPQYQQPADPAYPQQYPQPTPGYAQPEQFGAQPTQLGVPGQYGQYQQPGQYGQ
PGQYGQPGQYAPPGQYPGQYGPYGQSGQGSKRSVAVIGGVIAVMAVLFIGAVLILGFW
APGFFVTTKLDVIKAQAGVQQVLTDETTGYGAKNVKDVKCNNGSDPTVKKGATFECTV
SIDGTSKRVTVTFQDNKGTYEVGRPQ"
gene complement(2349334..2352054)
/gene="helY"
/locus_tag="Rv2092c"
CDS complement(2349334..2352054)
/codon_start=1
/transl_table=11
/gene="helY"
/locus_tag="Rv2092c"
/product="ATP-dependent DNA helicase HelY"
/note="Rv2092c, (MTCY49.32c), len: 906 aa.
HelY,ATP-dependent DNA helicase, similar to many; contains
PS00017 ATP/GTP-binding site motif A, PS00402
Binding-protein-dependent transport systems inner membrane
component signature. Belongs to the SKI2 subfamily of
helicases."
/db_xref="EnsemblGenomes-Gn:Rv2092c"
/db_xref="EnsemblGenomes-Tr:CCP44867"
/db_xref="GOA:P9WMR1"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR012961"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WMR1"
/inference="protein motif:PROSITE:PS00402"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44867.1"
/translation="MTELAELDRFTAELPFSLDDFQQRACSALERGHGVLVCAPTGAG
KTVVGEFAVHLALAAGSKCFYTTPLKALSNQKHTDLTARYGRDQIGLLTGDLSVNGNA
PVVVMTTEVLRNMLYADSPALQGLSYVVMDEVHFLADRMRGPVWEEVILQLPDDVRVV
SLSATVSNAEEFGGWIQTVRGDTTVVVDEHRPVPLWQHVLVGKRMFDLFDYRIGEAEG
QPQVNRELLRHIAHRREADRMADWQPRRRGSGRPGFYRPPGRPEVIAKLDAEGLLPAI
TFVFSRAGCDAAVTQCLRSPLRLTSEEERARIAEVIDHRCGDLADSDLAVLGYYEWRE
GLLRGLAAHHAGMLPAFRHTVEELFTAGLVKAVFATETLALGINMPARTVVLERLVKF
NGEQHMPLTPGEYTQLTGRAGRRGIDVEGHAVVIWHPEIEPSEVAGLASTRTFPLRSS
FAPSYNMTINLVHRMGPQQAHRLLEQSFAQYQADRSVVGLVRGIERGNRILGEIAAEL
GGSDAPILEYARLRARVSELERAQARASRLQRRQAATDALAALRRGDIITITHGRRGG
LAVVLESARDRDDPRPLVLTEHRWAGRISSADYSGTTPVGSMTLPKRVEHRQPRVRRD
LASALRSAAAGLVIPAARRVSEAGGFHDPELESSREQLRRHPVHTSPGLEDQIRQAER
YLRIERDNAQLERKVAAATNSLARTFDRFVGLLTEREFIDGPATDPVVTDDGRLLARI
YSESDLLVAECLRTGAWEGLKPAELAGVVSAVVYETRGGDGQGAPFGADVPTPRLRQA
LTQTSRLSTTLRADEQAHRITPSREPDDGFVRVIYRWSRTGDLAAALAAADVNGSGSP
LLAGDFVRWCRQVLDLLDQVRNAAPNPELRATAKRAIGDIRRGVVAVDAG"
gene complement(2352103..2353029)
/gene="tatC"
/locus_tag="Rv2093c"
CDS complement(2352103..2353029)
/codon_start=1
/transl_table=11
/gene="tatC"
/locus_tag="Rv2093c"
/product="Sec-independent protein translocase
transmembrane protein TatC"
/note="Rv2093c, (MT2154, MTCY49.33c), len: 308 aa.
TatC,transmembrane protein, component of twin-arginine
translocation protein export system (see citation
below),similar to many. Belongs to the TatC family."
/db_xref="EnsemblGenomes-Gn:Rv2093c"
/db_xref="EnsemblGenomes-Tr:CCP44868"
/db_xref="GOA:P9WG97"
/db_xref="InterPro:IPR002033"
/db_xref="InterPro:IPR019820"
/db_xref="UniProtKB/Swiss-Prot:P9WG97"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44868.1"
/translation="MRAAGLLKRLNPRNRRSRVNPDATMSLVDHLTELRTRLLISLAA
ILVTTIFGFVWYSHSIFGLDSLGEWLRHPYCALPQSARADISADGECRLLATAPFDQF
MLRLKVGMAAGIVLACPVWFYQLWAFITPGLYQRERRFAVAFVIPAAVLFVAGAVLAY
LVLSKALGFLLTVGSDVQVTALSGDRYFGFLLNLLVVFGVSFEFPLLIVMLNLAGLLT
YERLKSWRRGLIFAMFVFAAIFTPGSDPFSMTALGAALTVLLELAIQIARVHDKRKAK
REAAIPDDEASVIDPPSPVPAPSVIGSHDDVT"
gene complement(2353046..2353297)
/gene="tatA"
/locus_tag="Rv2094c"
CDS complement(2353046..2353297)
/codon_start=1
/transl_table=11
/gene="tatA"
/locus_tag="Rv2094c"
/product="Sec-independent protein translocase
membrane-bound protein TatA"
/note="Rv2094c, (MT2155, MTCY49.34c), len: 83 aa.
TatA,membrane-bound protein, component of twin-arginine
translocation protein export system (see Berks et
al.,2000), similar to many. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
TATA/E family."
/db_xref="EnsemblGenomes-Gn:Rv2094c"
/db_xref="EnsemblGenomes-Tr:CCP44869"
/db_xref="GOA:P9WGA1"
/db_xref="InterPro:IPR003369"
/db_xref="InterPro:IPR006312"
/db_xref="UniProtKB/Swiss-Prot:P9WGA1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44869.1"
/translation="MGSLSPWHWAILAVVVIVLFGAKKLPDAARSLGKSLRIFKSEVR
ELQNENKAEASIETPTPVQSQRVDPSAASGQDSTEARPA"
gene complement(2353365..2354315)
/gene="pafC"
/locus_tag="Rv2095c"
CDS complement(2353365..2354315)
/codon_start=1
/transl_table=11
/gene="pafC"
/locus_tag="Rv2095c"
/product="Proteasome accessory factor C PafC"
/note="Rv2095c, (MTCY49.35c), len: 316 aa. PafC,
proteasome accessory factor C, similar to many. Contains
possible helix-turn-helix motif at aa 25-46, (+2.92 SD).
PafB|Rv2096c and PafC|Rv2095c interact (See Festa et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2095c"
/db_xref="EnsemblGenomes-Tr:CCP44870"
/db_xref="GOA:P9WIL9"
/db_xref="InterPro:IPR026881"
/db_xref="InterPro:IPR028349"
/db_xref="UniProtKB/Swiss-Prot:P9WIL9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44870.1"
/translation="MSALSTRLVRLLNMVPYFQANPRITRAEAAAELGVTAKQLEEDL
NQLWMCGLPGYSPGDLIDFEFCGDTIEVTFSAGIDRPLKLTSPEATGLLVALRALADI
PGVVDPQAARSAIAKIAAAAGAVAAVAEQAPTESPAAAAVRAAVRNSRALTIDYYAAS
HDTLTTRIVDPIRVLLIGGHSYLEAWSREAEGVRLFRFDRIVDAAELGEPAVPPESAR
QAPPDTSLFDGDLSLPSATLRVAPSASWMLEYYPIRELRQLPDGSCEVAMTYASEDWM
TRLLLGFGSDVRVLAPESLAQRVRDAATAALDAYQAAAPP"
gene complement(2354312..2355310)
/gene="pafB"
/locus_tag="Rv2096c"
CDS complement(2354312..2355310)
/codon_start=1
/transl_table=11
/gene="pafB"
/locus_tag="Rv2096c"
/product="Proteasome accessory factor B PafB"
/note="Rv2096c, (MTCY49.36c), len: 332 aa. PafB,
proteasome accessory factor B, similar to many.
PafB|Rv2096c and PafC|Rv2095c interact (See Festa et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv2096c"
/db_xref="EnsemblGenomes-Tr:CCP44871"
/db_xref="GOA:P9WIM1"
/db_xref="InterPro:IPR026881"
/db_xref="UniProtKB/Swiss-Prot:P9WIM1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44871.1"
/translation="MATSKVERLVNLVIALLSTRGYITAEKIRSSVAGYSDSPSVEAF
SRMFERDKNELRDLGIPLEVGRVSALEPTEGYRINRDAYALSPVELTPDEAAAVAVAT
QLWESPELITATQGALLKLRAAGVDVDPLDTGAPVAIASAAAVSGLRGSEDVLGILLS
AIDSGQVVQFSHRSSRAEPYTVRTVEPWGVVTEKGRWYLVGHDRDRDATRVFRLSRIG
AQVTPIGPAGATTVPAGVDLRSIVAQKVTEVPTGEQATVWVAEGRATALRRAGRSAGP
RQLGGRDGEVIELEIRSSDRLAREITGYGADAIVLQPGSLRDDVLARLRAQAGALA"
gene complement(2355319..2356677)
/gene="pafA"
/gene_synonym="paf"
/locus_tag="Rv2097c"
CDS complement(2355319..2356677)
/codon_start=1
/transl_table=11
/gene="pafA"
/gene_synonym="paf"
/locus_tag="Rv2097c"
/product="Proteasome accessory factor a PafA"
/note="Rv2097c, (MTCY49.37c), len: 452 aa. PafA,
proteasome accessory factor A, similar to many. Belongs to
the carboxylate amine/ammonia ligase family."
/db_xref="EnsemblGenomes-Gn:Rv2097c"
/db_xref="EnsemblGenomes-Tr:CCP44872"
/db_xref="GOA:P9WNU7"
/db_xref="InterPro:IPR004347"
/db_xref="InterPro:IPR022279"
/db_xref="UniProtKB/Swiss-Prot:P9WNU7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44872.1"
/translation="MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSS
NVFLRNGARLYLDVGSHPEYATAECDSLVQLVTHDRAGEWVLEDLLVDAEQRLADEGI
GGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQT
PKAATYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMSET
TTMLKVGTAALVLEMIESGVAFRDFSLDNPIRAIREVSHDVTGRRPVRLAGGRQASAL
DIQREYYTRAVEHLQTREPNAQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLF
QRYQDRYDMELSHPKIAQLDLAYHDIKRGRGIFDLLQRKGLAARVTTDEEIAEAVDQP
PQTTRARLRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIA
SM"
gene complement(2356729..2358033)
/pseudo
/gene="PE_PGRS36"
/locus_tag="Rv2098c"
CDS complement(2356729..2358033)
/codon_start=1
/transl_table=11
/gene="PE_PGRS36"
/locus_tag="Rv2098c"
/product="PE-PGRS family protein PE_PGRS36"
/note="Rv2098c, (MTCY49.38c), len: 434 aa.
PE_PGRS36,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below). Frameshifted near N-terminus (see Rv2099c|PE21)."
/pseudogene="unknown"
gene complement(2358033..2358206)
/pseudo
/gene="PE21"
/locus_tag="Rv2099c"
CDS complement(2358033..2358206)
/codon_start=1
/transl_table=11
/gene="PE21"
/locus_tag="Rv2099c"
/product="PE family protein PE21"
/note="Rv2099c, (MTCY49.39c), len: 58 aa. PE21, Member of
the Mycobacterium tuberculosis PE family (see Brennan and
Delogu, 2002); 5'-end of Rv2098c|PE_PGRS36|MTCY49.38c,
then frameshifts. Sequence has been checked, no errors
found."
/pseudogene="unknown"
gene 2358389..2360041
/locus_tag="Rv2100"
CDS 2358389..2360041
/codon_start=1
/transl_table=11
/locus_tag="Rv2100"
/product="Conserved hypothetical protein"
/note="Rv2100, (MTCY49.40), len: 550 aa. Conserved
hypothetical protein. Member of Mycobacterium tuberculosis
REP13E12 repeat family with Rv1148c, Rv1945,
Rv3467,Rv0094c, Rv1128c, Rv1587c, Rv1702c, Rv3466,
Rv1588c."
/db_xref="EnsemblGenomes-Gn:Rv2100"
/db_xref="EnsemblGenomes-Tr:CCP44875"
/db_xref="GOA:P9WLJ3"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P9WLJ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44875.1"
/translation="MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISL
PDPTELCRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTGADQRADWACDFWD
CAAAEVAAALTISHGKASGQMHLSLALNRLPQVAALFLAGHLGARLFSIIAWRTYLVR
DPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWIDRYDPGALRRSRISARTRDLCIG
DPDEDAGTAALWGRLYATDAAMLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGAD
HLACGCGKPDCPSGAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETT
LFEALTPDPEPDPPATHAPAELITTGGGVVPAPLLAELIRGGATISQVRHPGDLAAEP
HYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAPWPLGPTHPSNLKCACRKHHL
LKTFWTGWRDVQLPDGTVIWTAPNGHTYTTHPGSRIFFPTWHTTTAELPQTSTAAVNV
DARGLMMPRRRRTRAAELAHRINAERALNDAYMAERNKPPSF"
gene 2360240..2363281
/gene="helZ"
/locus_tag="Rv2101"
CDS 2360240..2363281
/codon_start=1
/transl_table=11
/gene="helZ"
/locus_tag="Rv2101"
/product="Probable helicase HelZ"
/note="Rv2101, (MTV020.01), len: 1013 aa. Probable
helZ,helicase, similar to many. Nucleotide position
2361623 in the genome sequence has been corrected, A:C
resulting in M462L."
/db_xref="EnsemblGenomes-Gn:Rv2101"
/db_xref="EnsemblGenomes-Tr:CCP44876"
/db_xref="GOA:I6YCF3"
/db_xref="InterPro:IPR000330"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR022138"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR038718"
/db_xref="UniProtKB/TrEMBL:I6YCF3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44876.1"
/translation="MLVLHGFWSNSGGMRLWAEDSDLLVKSPSQALRSARPHPFAAPA
DLIAGIHPGKPATAVLLLPSLRSAPLDSPELIRLAPRPAARTDPMLLAWTVPVVDLDP
TAALAAFDQPAPDVRYGASVDYLAELAVFARELVERGRVLPQLRRDTHGAAACWRPVL
QGRDVVAMTSLVSAMPPVCRAEVGGHDPHELATSALDAMVDAAVRAALSPMDLLPPRR
GRSKRHRAVEAWLTALTCPDGRFDAEPDELDALAEALRPWDDVGIGTVGPARATFRLS
EVETENEETPAGSLWRLEFLLQSTQDPSLLVPAEQAWNDDGSLRRWLDRPQELLLTEL
GRASRIFPELVPALRTACPSGLELDADGAYRFLSGTAAVLDEAGFGVLLPSWWDRRRK
LGLVLSAYTPVDGVVGKASKFGREQLVEFRWELAVGDDPLSEEEIAALTETKSPLIRL
RGQWVALDTEQLRRGLEFLERKPTGRKTTAEILALAASHPDDVDTPLEVTAVRADGWL
GDLLAGAAAASLQPLDPPDGFTATLRPYQQRGLAWLAFLSSLGLGSCLADDMGLGKTV
QLLALETLESVQRHQDRGVGPTLLLCPMSLVGNWPQEAARFAPNLRVYAHHGGARLHG
EALRDHLERTDLVVSTYTTATRDIDELAEYEWNRVVLDEAQAVKNSLSRAAKAVRRLR
AAHRVALTGTPMENRLAELWSIMDFLNPGLLGSSERFRTRYAIPIERHGHTEPAERLR
ASTRPYILRRLKTDPAIIDDLPEKIEIKQYCQLTTEQASLYQAVVADMMEKIENTEGI
ERRGNVLAAMAKLKQVCNHPAQLLHDRSPVGRRSGKVIRLEEILEEILAEGDRVLCFT
QFTEFAELLVPHLAARFGRAARDIAYLHGGTPRKRRDEMVARFQSGDGPPIFLLSLKA
GGTGLNLTAANHVVHLDRWWNPAVENQATDRAFRIGQRRTVQVRKFICTGTLEEKIDE
MIEEKKALADLVVTDGEGWLTELSTRDLREVFALSEGAVGE"
gene 2363391..2364107
/locus_tag="Rv2102"
CDS 2363391..2364107
/codon_start=1
/transl_table=11
/locus_tag="Rv2102"
/product="Conserved hypothetical protein"
/note="Rv2102, (MTV020.02), len: 238 aa. Conserved
hypothetical protein, similar to many. Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2102"
/db_xref="EnsemblGenomes-Tr:CCP44877"
/db_xref="GOA:O53500"
/db_xref="InterPro:IPR007527"
/db_xref="UniProtKB/Swiss-Prot:O53500"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP44877.1"
/translation="MLEDIGLGNRLQRGRSYARKGQVISLQVDAGLVTALVQGSRARP
YRIRIGIPAFGKSQWAHVERTLAENAWYAAKLLSGEMPEDIEDVFAGLGLSLFPGTAR
ELSLDCSCPDYAVPCKHLAATFYLLAESFDEDPFAILAWRGREREDLLANLAAARADG
AAPAADHAEQVAQPLTDCLDRYYARQADINVPSPPATPSTALLDQLPDTGLSARGRPL
TELLRPAYHALTHHHNSAGG"
gene complement(2364086..2364520)
/gene="vapC37"
/locus_tag="Rv2103c"
CDS complement(2364086..2364520)
/codon_start=1
/transl_table=11
/gene="vapC37"
/locus_tag="Rv2103c"
/product="Possible toxin VapC37. Contains PIN domain."
/note="Rv2103c, (MTV020.03), len: 144 aa. Possible
vapC37,toxin, part of toxin-antitoxin (TA) operon with
Rv2104c,contains PIN domain, see Arcus et al. 2005.
Similar to others in Mycobacterium tuberculosis including
Rv0749,Rv0277c, Rv2530c, Rv3320c, Rv2494, Rv2872, Rv0617,
Rv1242 etc."
/db_xref="EnsemblGenomes-Gn:Rv2103c"
/db_xref="EnsemblGenomes-Tr:CCP44878"
/db_xref="GOA:O53501"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:O53501"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44878.1"
/translation="MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPL
LAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAVLVNPTVRHADILARMLTYVGTG
ANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL"
gene complement(2364527..2364781)
/gene="vapB37"
/locus_tag="Rv2104c"
CDS complement(2364527..2364781)
/codon_start=1
/transl_table=11
/gene="vapB37"
/locus_tag="Rv2104c"
/product="Possible antitoxin VapB37"
/note="Rv2104c, (MTV020.04), len: 84 aa. Possible
vapB37,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2103c, see Arcus et al. 2005. Similar to others in M.
tuberculosis including Rv2871, Rv1241, Rv2132,
Rv3321c,Rv1113, Rv0657, Rv1560, etc."
/db_xref="EnsemblGenomes-Gn:Rv2104c"
/db_xref="EnsemblGenomes-Tr:CCP44879"
/db_xref="UniProtKB/Swiss-Prot:P9WJ27"
/protein_id="CCP44879.1"
/translation="MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAP
SHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQRRGS"
mobile_element 2365414..2366768
/mobile_element_type="insertion sequence:IS6110-5"
/note="IS6110-5, len: 1355 nt. Insertion sequence IS6110."
repeat_region 2365414..2365441
/note="28bp inverted repeat at the left end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene 2365465..2365791
/locus_tag="Rv2105"
CDS 2365465..2365791
/codon_start=1
/transl_table=11
/locus_tag="Rv2105"
/product="Putative transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv2105, (MTCY261.01), len: 108 aa. Putative
transposase for IS6110 (fragment), identical to many other
Mycobacterium tuberculosis IS6110 transposase subunits
e.g. Q50686|YIA4_MYCTU Insertion element IS6110
hypothetical 12.0 kDa protein (108 aa), fasta scores: E():
1.4e-43,(100.00% identity in 108 aa overlap). The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv2105 and Rv2106,
the sequence UUUUAAAG (directly upstream of Rv2106) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv2105"
/db_xref="EnsemblGenomes-Tr:CCP44880"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP44880.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <2365740..2366726
/locus_tag="Rv2106"
CDS <2365740..2366726
/codon_start=1
/transl_table=11
/locus_tag="Rv2106"
/product="Probable transposase"
/note="Rv2106, (MTCY261.02), len: 328 aa. Probable
transposase subunit for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv2105 and Rv2106, the
sequence UUUUAAAG (directly upstream of Rv2106) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (+ 16
aa)."
/db_xref="EnsemblGenomes-Gn:Rv2106"
/db_xref="EnsemblGenomes-Tr:CCP44881"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP44881.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(2366741..2366768)
/note="28bp inverted repeat at the right end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC"
gene 2367359..2367655
/gene="PE22"
/locus_tag="Rv2107"
CDS 2367359..2367655
/codon_start=1
/transl_table=11
/gene="PE22"
/locus_tag="Rv2107"
/product="PE family protein PE22"
/note="Rv2107, (MTCY261.03), len: 98 aa. PE22, Member of
mycobacterial PE family (see citation below). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2107"
/db_xref="EnsemblGenomes-Tr:CCP44882"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N6B5"
/protein_id="CCP44882.1"
/translation="MSFVNVDPFGMLAAAATLESLGSHMAVSNAAVASVTTKVPPPAA
DYVSKKLSLFFSSHGQQYQVQAARGTAFHRKLVRTLANGALAYEEVEIANNEGF"
gene 2367711..2368442
/gene="PPE36"
/locus_tag="Rv2108"
CDS 2367711..2368442
/codon_start=1
/transl_table=11
/gene="PPE36"
/locus_tag="Rv2108"
/product="PPE family protein PPE36"
/note="Rv2108, (MTCY261.04), len: 243 aa. PPE36, Member of
the Mycobacterium tuberculosis PE family: N-terminus is
similar to N-terminal region of Mycobacterium tuberculosis
PPE family proteins. A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2108"
/db_xref="EnsemblGenomes-Tr:CCP44883"
/db_xref="GOA:P9WI01"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WI01"
/protein_id="CCP44883.1"
/translation="MPNFWALPPEINSTRIYLGPGSGPILAAAQGWNALASELEKTKV
GLQSALDTLLESYRGQSSQALIQQTLPYVQWLTTTAEHAHKTAIQLTAAANAYEQARA
AMVPPAMVRANRVQTTVLKAINWFGQFSTRIADKEADYEQMWFQDALVMENYWEAVQE
AIQSTSHFEDPPEMADDYDEAWMLNTVFDYHNENAKEEVIHLVPDVNKERGPIELVTK
VDKEGTIRLVYDGEPTFSYKEHPKF"
gene complement(2368983..2369729)
/gene="prcA"
/locus_tag="Rv2109c"
CDS complement(2368983..2369729)
/codon_start=1
/transl_table=11
/gene="prcA"
/locus_tag="Rv2109c"
/product="Proteasome alpha subunit PrcA; assembles with
beta subunit PrcB."
/note="Rv2109c, (MTCY261.05c), len: 248 aa.
PrcA,proteasome alpha-type subunit 1. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007). prcBA genes encode a proteasome with
broad substrate specificity (See Lin et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv2109c"
/db_xref="EnsemblGenomes-Tr:CCP44884"
/db_xref="GOA:P9WHU1"
/db_xref="InterPro:IPR001353"
/db_xref="InterPro:IPR022296"
/db_xref="InterPro:IPR023332"
/db_xref="InterPro:IPR029055"
/db_xref="PDB:2FHG"
/db_xref="PDB:2FHH"
/db_xref="PDB:3H6F"
/db_xref="PDB:3H6I"
/db_xref="PDB:3HF9"
/db_xref="PDB:3HFA"
/db_xref="PDB:3KRD"
/db_xref="PDB:3MFE"
/db_xref="PDB:3MI0"
/db_xref="PDB:3MKA"
/db_xref="PDB:5LZP"
/db_xref="PDB:5THO"
/db_xref="PDB:5TRG"
/db_xref="PDB:5TRR"
/db_xref="PDB:5TRS"
/db_xref="PDB:5TRY"
/db_xref="PDB:5TS0"
/db_xref="PDB:6BGL"
/db_xref="PDB:6BGO"
/db_xref="UniProtKB/Swiss-Prot:P9WHU1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44884.1"
/translation="MSFPYFISPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAE
NPSRSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANV
YAQTLGTIFTEQAKPYEVELCVAEVAHYGETKRPELYRITYDGSIADEPHFVVMGGTT
EPIANALKESYAENASLTDALRIAVAALRAGSADTSGGDQPTLGVASLEVAVLDANRP
RRAFRRITGSALQALLVDQESPQSDGESSG"
gene complement(2369726..2370601)
/gene="prcB"
/locus_tag="Rv2110c"
CDS complement(2369726..2370601)
/codon_start=1
/transl_table=11
/gene="prcB"
/locus_tag="Rv2110c"
/product="Proteasome beta subunit PrcB; assembles with
alpha subunit PrcA."
/note="Rv2110c, (MTCY261.06c), len: 291 aa.
PrcB,proteasome beta-type subunit 2. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007). prcBA genes encode a proteasome with
broad substrate specificity (See Lin et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv2110c"
/db_xref="EnsemblGenomes-Tr:CCP44885"
/db_xref="GOA:P9WHT9"
/db_xref="InterPro:IPR001353"
/db_xref="InterPro:IPR022483"
/db_xref="InterPro:IPR023333"
/db_xref="InterPro:IPR029055"
/db_xref="PDB:2FHG"
/db_xref="PDB:2FHH"
/db_xref="PDB:2JAY"
/db_xref="PDB:3H6F"
/db_xref="PDB:3H6I"
/db_xref="PDB:3HF9"
/db_xref="PDB:3HFA"
/db_xref="PDB:3KRD"
/db_xref="PDB:3MFE"
/db_xref="PDB:3MI0"
/db_xref="PDB:3MKA"
/db_xref="PDB:5LZP"
/db_xref="PDB:5THO"
/db_xref="PDB:5TRG"
/db_xref="PDB:5TRR"
/db_xref="PDB:5TRS"
/db_xref="PDB:5TRY"
/db_xref="PDB:5TS0"
/db_xref="PDB:6BGL"
/db_xref="PDB:6BGO"
/db_xref="UniProtKB/Swiss-Prot:P9WHT9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44885.1"
/translation="MTWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGG
APLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGI
AGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPL
LAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGD
SGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIE
SRSGADTFGSDGGEK"
gene complement(2370598..2370792)
/gene="pup"
/locus_tag="Rv2111c"
CDS complement(2370598..2370792)
/codon_start=1
/transl_table=11
/gene="pup"
/locus_tag="Rv2111c"
/product="Prokaryotic ubiquitin-like protein Pup"
/note="Rv2111c, MTCY261.07c, len: 64 aa. Pup, prokaryotic
ubiquitin-like protein (See Pearce et al., 2008). Highly
similar to many. Pup|Rv2111c and Mpa|Rv2115c interact (See
Pearce et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2111c"
/db_xref="EnsemblGenomes-Tr:CCP44886"
/db_xref="GOA:P9WHN5"
/db_xref="InterPro:IPR008515"
/db_xref="PDB:3M91"
/db_xref="PDB:3M9D"
/db_xref="UniProtKB/Swiss-Prot:P9WHN5"
/protein_id="CCP44886.1"
/translation="MAQEQTKRGGGGGDDDDIAGSTAAGQERREKLTEETDDLLDEID
DVLEENAEDFVRAYVQKGGQ"
gene complement(2370905..2372569)
/gene="dop"
/locus_tag="Rv2112c"
CDS complement(2370905..2372569)
/codon_start=1
/transl_table=11
/gene="dop"
/locus_tag="Rv2112c"
/product="Deamidase of pup Dop"
/note="Rv2112c, (MTCY261.08c), len: 554 aa. Dop, deamidase
of Pup (See Streibel et al., 2009). Highly similar to
many. Cofactor: ATP. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2112c"
/db_xref="EnsemblGenomes-Tr:CCP44887"
/db_xref="GOA:P9WNU9"
/db_xref="InterPro:IPR004347"
/db_xref="InterPro:IPR022366"
/db_xref="UniProtKB/Swiss-Prot:P9WNU9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44887.1"
/translation="MFWVGGPCLMPASSAARCAARIVGGRCLMPASSAARCAARIVGG
PRLYGMQRIIGTEVEYGISSPSDPTANPILTSTQAVLAYAAAAGIQRAKRTRWDYEVE
SPLRDARGFDLSRSAGPPPVVDADEVGAANMILTNGARLYVDHAHPEYSAPECTDPLD
AVIWDKAGERVMEAAARHVASVPGAAKLQLYKNNVDGKGASYGSHENYLMSRQTPFSA
IITGLTPFLVSRQVVTGSGRVGIGPSGDEPGFQLSQRSDYIEVEVGLETTLKRGIINT
RDEPHADADRYRRLHVIIGDANLAETSTYLKLGTTALVLDLIEEGPAHAIDLTDLALA
RPVHAVHAISRDPSLRATVALADGRELTGLALQRIYLDRVAKLVDSRDPDPRAADIVE
TWAHVLDQLERDPMDCAELLDWPAKLRLLDGFRQRENLSWSAPRLHLVDLQYSDVRLD
KGLYNRLVARGSMKRLVTEHQVLSAVENPPTDTRAYFRGECLRRFGADIAAASWDSVI
FDLGGDSLVRIPTLEPLRGSKAHVGALLDSVDSAVELVEQLTAEPR"
repeat_region 2372437..2372492
/note="56 bp direct repeat 1,
GCCCGCCGACGATGCGGGCCGCGCAGCGGGCCGCTGAGGAGGCGGGCATCAAGCAA"
repeat_region 2372494..2372549
/note="56 bp direct repeat 2,
GCCCGCCGACGATGCGGGCCGCGCAGCGGGCCGCTGAGGAGGCGGGCATCAAGCAA"
gene 2372630..2373823
/locus_tag="Rv2113"
CDS 2372630..2373823
/codon_start=1
/transl_table=11
/locus_tag="Rv2113"
/product="Probable integral membrane protein"
/note="Rv2113, (MTCY261.09), len: 397 aa. Probable
integral membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv2113"
/db_xref="EnsemblGenomes-Tr:CCP44888"
/db_xref="GOA:O33248"
/db_xref="UniProtKB/TrEMBL:O33248"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44888.1"
/translation="MSLSVRRPPAARAAAIVEAESWFLKRGLPSVLTMRGRCRRLWPR
SAPMLAAWAVVEGCLMAVFFVTDGGEVFISATPTTAQWVILALLAVALPLASLVGWLV
SQISSGRGQAAVATMAVAFAAASDVIESGPIQLLRTAVVVGLVLLQTGCGVGSVLGWA
VRMTLEHLATVGTLAVRALPIVLLTALVFFNTYVWLMAANINGERLTLAMVFLLAIAG
AFVVSKTVERVRPLLRSTTVMPQGSQSLAGTPFATMGDPSPGFPLTRAERLNVVFLLA
ASQLVEILVVASVGAAIYLVLGMIILTPPLLREWTHYDSMTTTVLGMTFPAPDSLIRM
CLFLGALTFMYISARAVDDAEYRAMFLDPLIDDLHTALLARNRYRNNVVTAPCAGVDA
GHVDD"
gene 2373834..2374457
/locus_tag="Rv2114"
CDS 2373834..2374457
/codon_start=1
/transl_table=11
/locus_tag="Rv2114"
/product="Conserved protein"
/note="Rv2114, (MTCY261.10), len: 207 aa. Conserved
protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2114"
/db_xref="EnsemblGenomes-Tr:CCP44889"
/db_xref="GOA:O33249"
/db_xref="InterPro:IPR016792"
/db_xref="UniProtKB/TrEMBL:O33249"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44889.1"
/translation="MSAPERVTGLSGQRYGEVLLVTPGEAGPQATVYNSFPLNDCPAE
LWSALDPQALATEHKAATALLNGPRYWLMNAIEKAPQGPPVTKTFGGIEMLQQATVLL
SSMNPAPYTVSQVSRNTVFVFNAGEEVYELQDPKGQRWVMQTWSQVVDPNLSRADLPK
LGERLNLPAGWSYHTRVLTSELRVDTTNREARVLQDDLTNSYSLVTA"
gene complement(2374461..2376290)
/gene="mpa"
/locus_tag="Rv2115c"
CDS complement(2374461..2376290)
/codon_start=1
/transl_table=11
/gene="mpa"
/locus_tag="Rv2115c"
/product="Mycobacterial proteasome ATPase Mpa"
/note="Rv2115c, (MTCY261.11c), len: 609 aa.
Mpa,mycobacterial proteasome ATPase, similar to many.
Contains PS00674 AAA-protein family signature and PS00017
ATP/GTP-binding site motif A (P-loop). Identified as a
substrate for proteasomal degradation (See Pearce et
al.,2006). Pup|Rv2111c and Mpa|Rv2115c interact (See
Pearce et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2115c"
/db_xref="EnsemblGenomes-Tr:CCP44890"
/db_xref="GOA:P9WQN5"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR003960"
/db_xref="InterPro:IPR022482"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR032501"
/db_xref="InterPro:IPR041626"
/db_xref="PDB:3FP9"
/db_xref="PDB:3M91"
/db_xref="PDB:3M9B"
/db_xref="PDB:3M9D"
/db_xref="PDB:3M9H"
/db_xref="PDB:5KWA"
/db_xref="PDB:5KZF"
/db_xref="UniProtKB/Swiss-Prot:P9WQN5"
/inference="protein motif:PROSITE:PS00674"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44890.1"
/translation="MGESERSEAFGIPRDSPLSSGDAAELEQLRREAAVLREQLENAV
GSHAPTRSARDIHQLEARIDSLAARNSKLMETLKEARQQLLALREEVDRLGQPPSGYG
VLLATHDDDTVDVFTSGRKMRLTCSPNIDAASLKKGQTVRLNEALTVVEAGTFEAVGE
ISTLREILADGHRALVVGHADEERVVWLADPLIAEDLPDGLPEALNDDTRPRKLRPGD
SLLVDTKAGYAFERIPKAEVEDLVLEEVPDVSYADIGGLSRQIEQIRDAVELPFLHKE
LYREYSLRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDAHEAKSYFLNIKG
PELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTV
VPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIYS
KYLTEFLPVHADDLAEFDGDRSACIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVM
YFKDFNSGAMIQNVVDRAKKNAIKSVLETGQPGLRIQHLLDSIVDEFAENEDLPNTTN
PDDWARISGKKGERIVYIRTLVTGKSSSASRAIDTESNLGQYL"
gene 2376571..2377140
/gene="lppK"
/locus_tag="Rv2116"
CDS 2376571..2377140
/codon_start=1
/transl_table=11
/gene="lppK"
/locus_tag="Rv2116"
/product="Conserved lipoprotein LppK"
/note="Rv2116, (MTCY261.12), len: 189 aa. LppK, conserved
lipoprotein, similar to many. Contains N-terminal signal
sequence and PS00013 Prokaryotic membrane lipoprotein
lipid attachment site. Some similarity to Rv2376c. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2116"
/db_xref="EnsemblGenomes-Tr:CCP44891"
/db_xref="GOA:P9WK75"
/db_xref="UniProtKB/Swiss-Prot:P9WK75"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44891.1"
/translation="MRRNIRVTLGAATIVAALGLSGCSHPEFKRSSPPAPSLPPVTSS
PLEAAPITPLPAPEALIDVLSRLADPAVPGTNKVQLIEGATPENAAALDRFTTALRDG
SYLPMTFAANDIAWSDNKPSDVMATVVVTTAHPDNREFTFPMEFVSFKGGWQLSRQTA
EMLLAMGNSPDSTPSATSPAPAPSPTPPG"
gene 2377148..2377441
/locus_tag="Rv2117"
CDS 2377148..2377441
/codon_start=1
/transl_table=11
/locus_tag="Rv2117"
/product="Conserved hypothetical protein"
/note="Rv2117, (MTCY261.13), len: 97 aa. Conserved
hypothetical protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2117"
/db_xref="EnsemblGenomes-Tr:CCP44892"
/db_xref="InterPro:IPR007546"
/db_xref="InterPro:IPR036746"
/db_xref="UniProtKB/TrEMBL:O33252"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44892.1"
/translation="MWIGWLEFDVLLGDVRSLKQKRSVTRPLVAELQRKFSVSAAETG
SHDLYRRAGIGVAVVSGDRSHAVDVLDNAERLVAAHPEFELLSVRRGLHRTDD"
gene complement(2377470..2378312)
/locus_tag="Rv2118c"
CDS complement(2377470..2378312)
/codon_start=1
/transl_table=11
/locus_tag="Rv2118c"
/product="RNA methyltransferase"
/note="Rv2118c, (MTCY261.14c), len: 280 aa.
S-adenosyl-l-methionine-dependent RNA methyltransferase
(see citation below), similar to many. The larger
catalytic C-terminal domain binds the cofactor
S-adenosyl-l-methionine (AdoMet) and is involved in the
transfer of methyl group from AdoMet to the substrate."
/db_xref="EnsemblGenomes-Gn:Rv2118c"
/db_xref="EnsemblGenomes-Tr:CCP44893"
/db_xref="GOA:P9WFZ1"
/db_xref="InterPro:IPR014816"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:1I9G"
/db_xref="UniProtKB/Swiss-Prot:P9WFZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44893.1"
/translation="MSATGPFSIGERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDA
VIGLEQGSVVKSSNGALFLVLRPLLVDYVMSMPRGPQVIYPKDAAQIVHEGDIFPGAR
VLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNVSGCYGQPPDNWRLVVS
DLADSELPDGSVDRAVLDMLAPWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRA
KQCWTEPRAWETLQRGWNVVGLAVRPQHSMRGHTAFLVATRRLAPGAVAPAPLGRKRE
GRDG"
gene 2378386..2379222
/locus_tag="Rv2119"
CDS 2378386..2379222
/codon_start=1
/transl_table=11
/locus_tag="Rv2119"
/product="Conserved hypothetical protein"
/note="Rv2119, (MTCY261.15), len: 278 aa. Conserved
hypothetical protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2119"
/db_xref="EnsemblGenomes-Tr:CCP44894"
/db_xref="GOA:O33254"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR011604"
/db_xref="InterPro:IPR038726"
/db_xref="UniProtKB/TrEMBL:O33254"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44894.1"
/translation="MADQPDPPTPRPALSPSRATDFKQCPLLYRFRAIDRLPEATSAA
QLRGSVVHAALEQLYGLPAGLRSPDTARSLVQRAWDQMVAAEPELAGELDPGQPTQLL
EDARALVSGYYRLEDPTRFDPQCCEQRVEVELADGTLLRGYIDRIDVAATGELRVVDY
KTGKAPPAARALAEFKAMFQMKFYAVALFRSRGVPPTRLRLIYLADGQLLDYSPDRDE
LLRFEKTLMAIWRAIQSAGETGDFRPNPSRLCDWCPHQQRCPAFGGTPPPYPGWPTEP
AA"
gene complement(2379245..2379727)
/locus_tag="Rv2120c"
CDS complement(2379245..2379727)
/codon_start=1
/transl_table=11
/locus_tag="Rv2120c"
/product="Probable conserved integral membrane protein"
/note="Rv2120c, (MTCY261.16c), len: 160 aa. Probable
conserved integral membrane protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2120c"
/db_xref="EnsemblGenomes-Tr:CCP44895"
/db_xref="GOA:O33255"
/db_xref="InterPro:IPR008816"
/db_xref="UniProtKB/TrEMBL:O33255"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44895.1"
/translation="MTHVLVLLLALLIGVVAGLRSLTAPAVVSWAAFLGWINLHGTWA
SWMGNFVTVVIVSVLAVAELVNDKRPKTPPRTVTPVFAVRIILGAFAGAVIGTAWGYR
WGGLGAGVIGAVLGTMGGYQARTRLVAARGGHDLPIALLEDSVAVLGGFAIVAAAAAL
"
gene complement(2379806..2380660)
/gene="hisG"
/locus_tag="Rv2121c"
CDS complement(2379806..2380660)
/codon_start=1
/transl_table=11
/gene="hisG"
/locus_tag="Rv2121c"
/product="ATP phosphoribosyltransferase HisG"
/note="Rv2121c, (MTCY261.17c), len: 284 aa. HisG, ATP
phosphoribosyltransferase (see citation below), similar to
many."
/db_xref="EnsemblGenomes-Gn:Rv2121c"
/db_xref="EnsemblGenomes-Tr:CCP44896"
/db_xref="GOA:P9WMN1"
/db_xref="InterPro:IPR001348"
/db_xref="InterPro:IPR011322"
/db_xref="InterPro:IPR013115"
/db_xref="InterPro:IPR013820"
/db_xref="InterPro:IPR015867"
/db_xref="InterPro:IPR018198"
/db_xref="InterPro:IPR020621"
/db_xref="PDB:1NH7"
/db_xref="PDB:1NH8"
/db_xref="PDB:5LHT"
/db_xref="PDB:5LHU"
/db_xref="PDB:5U99"
/db_xref="UniProtKB/Swiss-Prot:P9WMN1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44896.1"
/translation="MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVE
FFFLRPKDIAIYVGSGELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNW
TTADLAGMRIATAYPNLVRKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGR
TLSQHDLVAFGEPLCDSEAVLIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYD
CPRSALKKATAITPGLESPTIAPLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILA
SDIRFCRF"
gene complement(2380663..2380944)
/gene="hisE"
/gene_synonym="irg1"
/locus_tag="Rv2122c"
CDS complement(2380663..2380944)
/codon_start=1
/transl_table=11
/gene="hisE"
/gene_synonym="irg1"
/locus_tag="Rv2122c"
/product="Phosphoribosyl-AMP pyrophosphatase HisE"
/note="Rv2122c, (MTCY261.18), len: 93 aa. HisE (alternate
gene name: irg1), phosphoribosyl-AMP cyclohydrolase (see
citation below), similar to many. Note that previously
misnamed hisI."
/db_xref="EnsemblGenomes-Gn:Rv2122c"
/db_xref="EnsemblGenomes-Tr:CCP44897"
/db_xref="GOA:P9WMM9"
/db_xref="InterPro:IPR008179"
/db_xref="InterPro:IPR021130"
/db_xref="PDB:1Y6X"
/db_xref="PDB:3C90"
/db_xref="UniProtKB/Swiss-Prot:P9WMM9"
/protein_id="CCP44897.1"
/translation="MQQSLAVKTFEDLFAELGDRARTRPADSTTVAALDGGVHALGKK
LLEEAGEVWLAAEHESNDALAEEISQLLYWTQVLMISRGLSLDDVYRKL"
gene 2381071..2382492
/gene="PPE37"
/gene_synonym="irg2"
/locus_tag="Rv2123"
CDS 2381071..2382492
/codon_start=1
/transl_table=11
/gene="PPE37"
/gene_synonym="irg2"
/locus_tag="Rv2123"
/product="PPE family protein PPE37"
/note="Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate
gene name: irg2), member of the Mycobacterium tuberculosis
PPE family of proteins but the C-terminus is not
repetitive (see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv2123"
/db_xref="EnsemblGenomes-Tr:CCP44898"
/db_xref="GOA:Q79FH3"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:Q79FH3"
/protein_id="CCP44898.1"
/translation="MTFPMWFAVPPEVPSAWLSTGMGPGPLLAAARAWHALAAQYTEI
ATELASVLAAVQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAAAAHETAAAGYTS
ALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNEADYLRMWIQAATVMSHYQAV
AHESVAATPSTPPAPQIVTSAASSAASSSFPDPTKLILQLLKDFLELLRYLAVELLPG
PLGDLIAQVLDWFISFVSGPVFTFLAYLVLDPLIYFGPFAPLTSPVLLPAGLTGLAGL
GAVSGPAGPMVERVHSDGPSRQSWPAATGVTLVGTNPAALVTTPAPAPTTSAAPTAPS
TPGSSAAQGLYAVGGPDGEGFNPIAKTTALAGVTTDAAAPAAKLPGDQAQSSASKATR
LRRRLRQHRFEFLADDGRLTMPNTPEMADVAAGNRGLDALGFAGTIPKSAPGSATGLT
HLGGGFADVLSQPMLPHTWDGSD"
gene complement(2382489..2386067)
/gene="metH"
/locus_tag="Rv2124c"
CDS complement(2382489..2386067)
/codon_start=1
/transl_table=11
/gene="metH"
/locus_tag="Rv2124c"
/product="5-methyltetrahydrofolate--homocystein
methyltransferase MetH (methionine synthase, vitamin-B12
dependent isozyme) (ms)"
/note="Rv2124c, (MTCY261.20c), len: 1192 aa.
MetH,methionine synthase, similar to many. Contains
PS00178 Aminoacyl-transfer RNA synthetases class-I
signature. Belongs to the vitamin-B12 dependent methionine
synthase family."
/db_xref="EnsemblGenomes-Gn:Rv2124c"
/db_xref="EnsemblGenomes-Tr:CCP44899"
/db_xref="GOA:O33259"
/db_xref="InterPro:IPR000489"
/db_xref="InterPro:IPR003726"
/db_xref="InterPro:IPR003759"
/db_xref="InterPro:IPR004223"
/db_xref="InterPro:IPR006158"
/db_xref="InterPro:IPR011005"
/db_xref="InterPro:IPR011822"
/db_xref="InterPro:IPR033706"
/db_xref="InterPro:IPR036589"
/db_xref="InterPro:IPR036594"
/db_xref="InterPro:IPR036724"
/db_xref="InterPro:IPR037010"
/db_xref="UniProtKB/Swiss-Prot:O33259"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44899.1"
/translation="MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRG
LEGCNEILNETRPDVLETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQK
GTAIARRVADELGSPDRKRYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGA
DAILVETCQDLLQLKAAVLGSRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTA
VEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPD
ELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAVANIKRPERQVSYEPSVSSLYTA
IPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYV
GRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPE
SRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILI
DTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNS
VFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFE
GVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLL
AGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGRIVLATVKGD
VHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMK
ENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIM
SAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADI
EVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRP
RLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRG
RFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIG
VQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDL
EDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV"
gene 2386293..2387171
/locus_tag="Rv2125"
CDS 2386293..2387171
/codon_start=1
/transl_table=11
/locus_tag="Rv2125"
/product="Conserved hypothetical protein"
/note="Rv2125, (MTCY261.21), len: 292 aa. Conserved
hypothetical protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2125"
/db_xref="EnsemblGenomes-Tr:CCP44900"
/db_xref="InterPro:IPR008492"
/db_xref="InterPro:IPR019151"
/db_xref="InterPro:IPR038389"
/db_xref="PDB:5UN0"
/db_xref="UniProtKB/TrEMBL:O33260"
/protein_id="CCP44900.1"
/translation="MTPSEGNAPLPELHNTVVVAAFEGWNDAGDAAGDAVAHLAASWQ
ALPIVEIDDEAYYDYQVNRPVIRQVDGVTRELQWPAMRISHCRPPGSDRDVVLMCGVE
PNMRWRTFCDELLAVIDKLNVDTVVILGALLADTPHTRPVPVSGAAYSAASARQFGLQ
ETRYEGPTGIAGVFQSACVGAGIPAVTFWAAVPHYVSHPPNPKATIALLRRVEDVLDV
EVPLADLPAQAEAWEREITETIAEDHELAEYVQTLEQHGDAAVDMNEALGNIDGDALA
AEFERYLRRRRPGFGR"
gene complement(2387202..2387972)
/gene="PE_PGRS37"
/locus_tag="Rv2126c"
CDS complement(2387202..2387972)
/codon_start=1
/transl_table=11
/gene="PE_PGRS37"
/locus_tag="Rv2126c"
/product="PE-PGRS family protein PE_PGRS37"
/note="Rv2126c, (MTCY261.22c), len: 256 aa.
PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to
the Gly-rich C-terminus of many members of the
Mycobacterium tuberculosis PGRS family."
/db_xref="EnsemblGenomes-Gn:Rv2126c"
/db_xref="EnsemblGenomes-Tr:CCP44901"
/db_xref="UniProtKB/TrEMBL:L0TBL4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44901.1"
/translation="MIGDGANGGPGQPGGPGGLLYGNGGHGGAGAAGQDRGAGNSAGL
IGNGGAGGAGGNGGIGGAGAPGGLGGDGGKGGFADEFTGGFAQGGRGGFGGNGNTGAS
GGMGGAGGAGGAGGAGGLLIGDGGAGGAGGIGGAGGVGGGGGAGGTGGGGVASAFGGG
NAFGGRGGDGGDGGDGGTGGAGGARGAGGAGGAGGWLSGHSGAHGAMGSGGEGGAGGG
GGARGEAGAGGGTSTGTNPGKAGAPGTQGDSGDPGPPG"
gene 2388616..2390085
/gene="ansP1"
/locus_tag="Rv2127"
CDS 2388616..2390085
/codon_start=1
/transl_table=11
/gene="ansP1"
/locus_tag="Rv2127"
/product="L-asparagine permease AnsP1"
/note="Rv2127, (MTCY261.26), len: 489 aa.
AnsP1,L-asparagine permease, integral membrane protein
similar to many. Contains PS00218 Amino acid permeases
signature. Seems to belong to the APC family."
/db_xref="EnsemblGenomes-Gn:Rv2127"
/db_xref="EnsemblGenomes-Tr:CCP44902"
/db_xref="GOA:P9WQM9"
/db_xref="InterPro:IPR002293"
/db_xref="InterPro:IPR004840"
/db_xref="InterPro:IPR004841"
/db_xref="UniProtKB/Swiss-Prot:P9WQM9"
/inference="protein motif:PROSITE:PS00218"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44902.1"
/translation="MSAASQRVGAFGEEAGYHKGLKPRQLQMIGIGGAIGTGLFLGAG
GRLAKAGPGLFLVYGVCGVFVFLILRALGELVLHRPSSGSFVSYAREFFGEKAAYAVG
WMYFLHWAMTSIVDTTAIATYLQRWTIFTVVPQWILALIALTVVLSMNLISVEWFGEL
EFWAALIKVLALMAFLVVGTVFLAGRYPVDGHSTGLSLWNNHGGLFPTSWLPLLIVTS
GVVFAYSAVELVGTAAGETAEPEKIMPRAINSVVARIAIFYVGSVALLALLLPYTAYK
AGESPFVTFFSKIGFHGAGDLMNIVVLTAALSSLNAGLYSTGRVMHSIAMSGSAPRFT
ARMSKSGVPYGGIVLTAVITLFGVALNAFKPGEAFEIVLNMSALGIIAGWATIVLCQL
RLHKLANAGIMQRPRFRMPFSPYSGYLTLLFLLVVLVTMASDKPIGTWTVATLIIVIP
ALTAGWYLVRKRVMAVARERLGHTGPFPAVANPPVRSRD"
gene 2390085..2390288
/locus_tag="Rv2128"
CDS 2390085..2390288
/codon_start=1
/transl_table=11
/locus_tag="Rv2128"
/product="Conserved transmembrane protein"
/note="Rv2128, (MTCY26.27), len: 67 aa. Conserved
transmembrane protein, similar to many."
/db_xref="EnsemblGenomes-Gn:Rv2128"
/db_xref="EnsemblGenomes-Tr:CCP44903"
/db_xref="GOA:O33262"
/db_xref="UniProtKB/TrEMBL:O33262"
/protein_id="CCP44903.1"
/translation="MLRRGESIIRNRYASKPPLYGMAMVFLAMAVVAVTAYFRMGWWS
IIGYAAAAIIGVIGFALAFRDLS"
gene complement(2390308..2391189)
/locus_tag="Rv2129c"
CDS complement(2390308..2391189)
/codon_start=1
/transl_table=11
/locus_tag="Rv2129c"
/product="Probable oxidoreductase"
/note="Rv2129c, (MTCY261.28), len: 293 aa. Probable
oxidoreductase, similar to many e.g. FABG_SYNY3|P73826
3-oxoacyl-[acyl-carrier protein] reductase (240 aa), FASTA
scores: opt: 241, E(): 5.1e-17, (32.7% identity in 196 aa
overlap); etc. Also similar to a number of other
Mycobacterium tuberculosis oxidoreductases e.g. MTCY210.04
(34.1% identity in 217 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2129c"
/db_xref="EnsemblGenomes-Tr:CCP44904"
/db_xref="GOA:O33263"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O33263"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44904.1"
/translation="MTSLQGKVVFITGAARGIGAEVARRLHNKGAKLVLTDLSKSELA
VMGAELGGDDRLLTVVADVRDLPAMQAAAETAVERFGGIDVVVANAGIASYGSVLKVD
PQAFRRVLDVNLLGNFHTVRATLPALIDRRGYVLIVSSLAAFAAPPGMAPYNMSKAGN
EHFANALRLEVAHLGVSVGSAHMSWIDTALVRDTKADLPAFAELLARLPWPLNKTTSV
NKCAAAFVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIRNTVAKLMPQMDAEV
AALGRFASAYTESLENS"
gene complement(2391215..2392459)
/gene="mshC"
/gene_synonym="cysS2"
/locus_tag="Rv2130c"
CDS complement(2391215..2392459)
/codon_start=1
/transl_table=11
/gene="mshC"
/gene_synonym="cysS2"
/locus_tag="Rv2130c"
/product="Cysteine:1D-myo-inosityl
2-amino-2-deoxy--D-glucopyranoside ligase MshC"
/note="Rv2130c, (MTCY261.29c), len: 414 aa.
MshC,cysteine:1D-myo-inosityl
2-amino-2-deoxy--D-glucopyranoside ligase (see Rawat et
al., 2002), similar to several cysteinyl-tRNA synthetases
e.g. SYC_ECOLI|P21888 cysteinyl-tRNA synthetase from
Escherichia coli (461 aa),FASTA scores: opt: 535, E(): 0,
(37.0% identity in 370 aa overlap); etc. Also similar to
Mycobacterium tuberculosis cysS|Rv3580c|MTCY06G11.27c,
(35.8% identity in 372 aa overlap). Contains a match to
Pfam entry PF01406 tRNA synthetases class I (C).
Previously known as cysS2."
/db_xref="EnsemblGenomes-Gn:Rv2130c"
/db_xref="EnsemblGenomes-Tr:CCP44905"
/db_xref="GOA:P9WJM9"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR017812"
/db_xref="InterPro:IPR024909"
/db_xref="InterPro:IPR032678"
/db_xref="UniProtKB/Swiss-Prot:P9WJM9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44905.1"
/translation="MQSWYCPPVPVLPGRGPQLRLYDSADRQVRPVAPGSKATMYVCG
ITPYDATHLGHAATYVTFDLIHRLWLDLGHELHYVQNITDIDDPLFERADRDGVDWRD
LAQAEVALFCEDMAALRVLPPQDYVGATEAIAEMVELIEKMLACGAAYVIDREMGEYQ
DIYFRADATLQFGYESGYDRDTMLRLCEERGGDPRRPGKSDELDALLWRAARPGEPSW
PSPFGPGRPGWHVECAAIALSRIGSGLDIQGGGSDLIFPHHEFTAAHAECVSGERRFA
RHYVHAGMIGWDGHKMSKSRGNLVLVSALRAQDVEPSAVRLGLLAGHYRADRFWSQQV
LDEATARLHRWRTATALPAGPAAVDVVARVRRYLADDLDTPKAIAALDGWVTDAVEYG
GHDAGAPKLVATAIDALLGVDL"
gene complement(2392517..2393320)
/gene="cysQ"
/locus_tag="Rv2131c"
CDS complement(2392517..2393320)
/codon_start=1
/transl_table=11
/gene="cysQ"
/locus_tag="Rv2131c"
/product="Monophosphatase CysQ"
/note="Rv2131c, (MTCY270.37), len: 267 aa.
CysQ,monophosphatase, equivalent to CYSQ_MYCLE|P46726 cysQ
protein homolog from Mycobacterium leprae (289 aa), FASTA
scores: opt: 1374, E(): 0, (77.3% identity in 264 aa
overlap). Contains inositol monophosphatase family
signature 1 (PS00629), significance uncertain. Seems to
belong to the inositol monophosphatase family. Cofactor:
Mg2+. Inhibited by Li+; PAPase activity is inhibited by
Na+ and K+, but IMPase activity is not (See Gu et al.,
2006; Hatzios et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2131c"
/db_xref="EnsemblGenomes-Tr:CCP44906"
/db_xref="GOA:P9WKJ1"
/db_xref="InterPro:IPR000760"
/db_xref="InterPro:IPR020583"
/db_xref="PDB:5DJF"
/db_xref="PDB:5DJG"
/db_xref="PDB:5DJH"
/db_xref="PDB:5DJI"
/db_xref="PDB:5DJJ"
/db_xref="PDB:5DJK"
/db_xref="UniProtKB/Swiss-Prot:P9WKJ1"
/inference="protein motif:PROSITE:PS00629"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44906.1"
/translation="MVSPAAPDLTDDLTDAELAADLAADAGKLLLQVRAEIGFDQPWT
LGEAGDRQANSLLLRRLQAERPGDAVLSEEAHDDLARLKSDRVWIIDPLDGTREFSTP
GRDDWAVHIALWRRSSNGQPEITDAAVALPARGNVVYRTDTVTSGAAPAGVPGTLRIA
VSATRPPAVLHRIRQTLAIQPVSIGSAGAKAMAVIDGYVDAYLHAGGQWEWDSAAPAG
VMLAAGMHASRLDGSPLRYNQLDPYLPDLLMCRAEVAPILLGAIADAWR"
gene 2393411..2393641
/locus_tag="Rv2132"
CDS 2393411..2393641
/codon_start=1
/transl_table=11
/locus_tag="Rv2132"
/product="Conserved hypothetical protein"
/note="Rv2132, (MTCY270.36c), len: 76 aa. Conserved
hypothetical protein. Function unknown but belongs to
Mycobacterium tuberculosis protein family including
Rv2871,Rv1241, Rv3321c, Rv1113, Rv0657c, Rv1560, Rv2104c,
etc. Similarity to Mycobacterium tuberculosis protein
Rv2871 (AL021924|MTV020_4, 84 aa). FASTA score: opt: 142,
E(): 0.00036; 41.8% identity in 55 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2132"
/db_xref="EnsemblGenomes-Tr:CCP44907"
/db_xref="GOA:O06243"
/db_xref="InterPro:IPR002145"
/db_xref="UniProtKB/TrEMBL:O06243"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44907.1"
/translation="MRTTVSLADDVAAAVQRLRKERSIGLSEAVNELIRAGLTKRQVA
NRFQQQTYDMGEGIDYSNIGDAIETLDGPASG"
gene complement(2393851..2394639)
/locus_tag="Rv2133c"
CDS complement(2393851..2394639)
/codon_start=1
/transl_table=11
/locus_tag="Rv2133c"
/product="Conserved hypothetical protein"
/note="Rv2133c, (MTCY270.35), len: 262 aa. Conserved
hypothetical protein. Function: unknown but equivalent to
hypothetical Mycobacterium leprae protein, Q49774. FASTA
best: Q49774 B2126_C1_150 (262 aa) opt: 1447, E(): 0;
(79.0% identity in 262 aa overlap). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2133c"
/db_xref="EnsemblGenomes-Tr:CCP44908"
/db_xref="InterPro:IPR022292"
/db_xref="UniProtKB/TrEMBL:O06242"
/protein_id="CCP44908.1"
/translation="MLADGELTVLGRIRSASNATFLCESTLGLRSLHCVYKPVSGERP
LWDFPDGTLAGRELSAYLVSTQLGWNLVPHTIIRDGPAGIGMLQLWVQQPGDAVDSDP
LPGPDLVDLFPAHRPRPGYLPVLRAYDYAGDEVVLMHADDIRLRRMAVFDVLINNADR
KGGHILCGIDGQVYGVDHGLCLHVENKLRTVLWGWAGKPIDDQILQAVAGLADALGGP
LAEALAGRIAAAEIGALRRRAQSLLDQPVMPGPNGHRPIPWPAF"
gene complement(2394650..2395237)
/locus_tag="Rv2134c"
CDS complement(2394650..2395237)
/codon_start=1
/transl_table=11
/locus_tag="Rv2134c"
/product="Conserved protein"
/note="Rv2134c, (MTCY270.34), len: 195 aa. Conserved
protein. Function: unknown but equivalent to hypothetical
Mycobacterium leprae protein, Q49789. FASTA best: Q49789
B2126_C3_228, opt: 1192, E(): 0 (91.1% identity in 192 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2134c"
/db_xref="EnsemblGenomes-Tr:CCP44909"
/db_xref="InterPro:IPR021441"
/db_xref="UniProtKB/TrEMBL:O06241"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44909.1"
/translation="MARAIHVFRTPDRFVAGTVGQPGNRTFYLQAVHDSRVVSVVLEK
QQVAVLAERIGALLFEVNRRFGTPVPPEPTEIDDLSPLIMPVDAEFRVGTMGLGWDSE
AQSVVVELLAVTDAEFDASVVLDDTEEGPDAVRVFLTPESARQFATRSYRVISAGRPP
CPLCDEPLDPEGHICARTNGYRRDVLLGSGDDPAG"
gene complement(2395301..2396011)
/locus_tag="Rv2135c"
CDS complement(2395301..2396011)
/codon_start=1
/transl_table=11
/locus_tag="Rv2135c"
/product="Conserved protein"
/note="Rv2135c, (MTCY270.33), len: 236 aa. Conserved
protein. Function: unknown but equivalent to hypothetical
Mycobacterium leprae protein, Q49773. FASTA best: Q49773
B2126_C1_148 opt: 1183, E() : 0; (74.8% identity in 250 aa
overlap), also similar in C-terminus to PMG2_ECOLI P36942
probable phosphoglycerate mutase 2 (215 aa), FASTA scores;
opt: 212, E(): 2.5e-07 27.9% identity in 190 aa overlap;
and to Rv2228 and Rv2419c"
/db_xref="EnsemblGenomes-Gn:Rv2135c"
/db_xref="EnsemblGenomes-Tr:CCP44910"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR022492"
/db_xref="InterPro:IPR029033"
/db_xref="UniProtKB/TrEMBL:O06240"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44910.1"
/translation="MTVILLRHARSTSNTAGVLAGRSGVDLDEKGREQATGLIDRIGD
LPIRAVASSPMLRCQRTVEPLAEALCLEPLIDDRFSEVDYGEWTGRKIGDLVDEPLWR
VVQAHPSAAVFPGGEGLAQVQTRAVAAVREHDRRLADQHGHDVLWLACTHGDVIKAVI
ADAFGMHLDSFQRITADPGSVSVVRYTQLRPFVLHVNHTGARLAPALQAAASAQGASP
EPNAAVPPGDAVIGGSTD"
gene complement(2396008..2396838)
/locus_tag="Rv2136c"
CDS complement(2396008..2396838)
/codon_start=1
/transl_table=11
/locus_tag="Rv2136c"
/product="Possible conserved transmembrane protein"
/note="Rv2136c, (MTCY270.32), len: 276 aa. Possible
conserved transmembrane protein, very similar to
hypothetical Mycobacterium leprae protein Q49783. FASTA
best: Q49783 B2126_C2_190 opt: 1023, E(): 0; (82.4%
identity in 187 aa over lap) similar to BACA_ECOLI P31054
bacitracin resistance protein (273 aa) opt: 477, E():
7e-26, (35.6% identity in 267 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2136c"
/db_xref="EnsemblGenomes-Tr:CCP44911"
/db_xref="GOA:P9WFF9"
/db_xref="InterPro:IPR003824"
/db_xref="UniProtKB/Swiss-Prot:P9WFF9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44911.1"
/translation="MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFT
AVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHRNTDYRLGWYVIIGTIPICILGL
FFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLA
LVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSA
TGPQLLVATLIAFVLGLTAVAWLLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT
"
gene complement(2396902..2397315)
/locus_tag="Rv2137c"
CDS complement(2396902..2397315)
/codon_start=1
/transl_table=11
/locus_tag="Rv2137c"
/product="Conserved hypothetical protein"
/note="Rv2137c, (MTCY270.31), len: 137 aa. Conserved
hypothetical protein. C-terminus is very similar to
hypothetical Mycobacterium leprae protein B2126_C2_188
(150 aa). FASTA best: Q49782 B2126_C2_188. (150 aa) opt:
469,E(): 9.6e-28; (77.2% identity in 101 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2137c"
/db_xref="EnsemblGenomes-Tr:CCP44912"
/db_xref="UniProtKB/TrEMBL:O06238"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44912.1"
/translation="MRNMKSTSHESESGKLLSISSCRPREMVLQRYSLGMTVTADRHL
ADKREEFAVEDISTGIFASGYGQVGDGRSFSFHIEHRSLVVEIYRPRVAGPVPQAEDV
VAMAVRGLVDIDLTDERSLAAAVRDSVASAAPVSR"
gene 2397330..2398406
/gene="lppL"
/locus_tag="Rv2138"
CDS 2397330..2398406
/codon_start=1
/transl_table=11
/gene="lppL"
/locus_tag="Rv2138"
/product="Probable conserved lipoprotein LppL"
/note="Rv2138, (MTCY270.30c), len: 358 aa. Probable
lppL,conserved lipoprotein, with appropriately placed
lipoprotein signature (PS00013) strongly similar to
hypothetical Mycobacterium leprae protein, Q49806. FASTA
best: Q49806 B2126_F3_142. (298 aa) opt: 1495, E(): 0;
(75.3% identity in 300 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2138"
/db_xref="EnsemblGenomes-Tr:CCP44913"
/db_xref="InterPro:IPR015943"
/db_xref="UniProtKB/TrEMBL:O06237"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44913.1"
/translation="MLTGNKPAVQRRFIGLLMLSVLVAGCSSNPLANFAPGYPPTIEP
AQPAVSPPTSQDPAGAVRPLSGHPRAALFDNGTRQLVALRPGADSAAPASIMVFDDVH
VAPRVIFLPGPAAALTSDDHGTAFLAARGGYFVADLSSGHTARVNVADAAHTDFTAIA
RRSDGKLVLGSADGAVYTLAKNPAVDPASGAATVASRTKIFARVDALVTQGNTTVVLD
RGQTSVTTIGADGHAQQALRAGQGATTMAADPLGRVLIADTRGGQLLVYGVDPLILRQ
AYPVRQAPYGLAGSRELAWVSQTASNTVIGYDLTTGIPVEKVRYPTVQQPNSLAFDET
SDTLYVVSGSGAGVQVIEHAAGTR"
gene 2398720..2399793
/gene="pyrD"
/locus_tag="Rv2139"
CDS 2398720..2399793
/codon_start=1
/transl_table=11
/gene="pyrD"
/locus_tag="Rv2139"
/product="Probable dihydroorotate dehydrogenase PyrD"
/note="Rv2139, (MTCY270.29c), len: 357 aa. Probable
pyrD,dihydroorotate dehydrogenase ; contains
dihydroorotate dehydrogenase signatures 1 and 2 (PS00911,
PS00912). FASTA best: PYRD_MYCLE P46727 dihydroorotate
dehydrogenase (309 aa) opt: 1653, E(): 0; (82.6% identity
in 304 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2139"
/db_xref="EnsemblGenomes-Tr:CCP44914"
/db_xref="GOA:P9WHL1"
/db_xref="InterPro:IPR001295"
/db_xref="InterPro:IPR005719"
/db_xref="InterPro:IPR005720"
/db_xref="InterPro:IPR013785"
/db_xref="PDB:4XQ6"
/db_xref="UniProtKB/Swiss-Prot:P9WHL1"
/inference="protein motif:PROSITE:PS00911"
/inference="protein motif:PROSITE:PS00912"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44914.1"
/translation="MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGP
TDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAP
RLFRLADDRALLNRMGFNNHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYR
ASARMVGPLASYLVVNVSSPNTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLS
DSDLDDIADLAVELDLAGIVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLR
RLYDRVGDRLALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGIAR
RLHDGGFGSLHEAVGSARRRQPS"
gene complement(2399798..2400328)
/gene="TB18.6"
/locus_tag="Rv2140c"
CDS complement(2399798..2400328)
/codon_start=1
/transl_table=11
/gene="TB18.6"
/locus_tag="Rv2140c"
/product="Conserved protein TB18.6"
/note="Rv2140c, (MTCY270.28), len: 176 aa.
TB18.6,conserved protein; shows good similarity to
hypothetical proteins from Streptomyces coelicolor (177
aa; 58% identity) >emb|CAC32358.1| (AL583945) and to 17.1
kDa Escherichia coli protein YbhB. FASTA best: YBHB_ECOLI
P12994 hypothetical 17.1 kDa protein (158 aa) opt: 465 E(
): 2e-23; (46.2% identity in 156 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2140c"
/db_xref="EnsemblGenomes-Tr:CCP44915"
/db_xref="GOA:P9WFN1"
/db_xref="InterPro:IPR005247"
/db_xref="InterPro:IPR008914"
/db_xref="InterPro:IPR036610"
/db_xref="PDB:4BEG"
/db_xref="UniProtKB/Swiss-Prot:P9WFN1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44915.1"
/translation="MTTSPDPYAALPKLPSFSLTSTSITDGQPLATPQVSGIMGAGGA
DASPQLRWSGFPSETRSFAVTVYDPDAPTLSGFWHWAVANLPANVTELPEGVGDGREL
PGGALTLVNDAGMRRYVGAAPPPGHGVHRYYVAVHAVKVEKLDLPEDASPAYLGFNLF
QHAIARAVIFGTYEQR"
gene complement(2400376..2401722)
/gene_synonym="dapE2"
/locus_tag="Rv2141c"
CDS complement(2400376..2401722)
/codon_start=1
/transl_table=11
/gene_synonym="dapE2"
/locus_tag="Rv2141c"
/product="Conserved protein"
/note="Rv2141c, (MTCY270.27), len: 448 aa. Conserved
protein. Shows some similarity to conserved hypothetical
proteins and to acetylornithine deacetylase and
succinyl-diaminopimelate desuccinylase and contains
ArgE/dapE/ACY1/CPG2/yscS family signature 1 (PS00758).
FASTA best: CBPS_YEAST P27614 carboxypeptidases precursor
(576 aa) opt: 234, E(): 4.3e-08; (24.3% identity in 412 aa
overlap). Previously named dapE2. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2141c"
/db_xref="EnsemblGenomes-Tr:CCP44916"
/db_xref="GOA:L7N684"
/db_xref="InterPro:IPR001261"
/db_xref="InterPro:IPR002933"
/db_xref="InterPro:IPR011650"
/db_xref="InterPro:IPR036264"
/db_xref="UniProtKB/TrEMBL:L7N684"
/inference="protein motif:PROSITE:PS00758"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44916.1"
/translation="MTDETGASSDHSDDVAQVVSRLIRFDTTNSGEPGTTKGEAECAR
WVAEQLAEVGYQPEYVESGAPGRGNVFARLAGADSSRGALLIHGHLDVVPAEPAEWSV
HPFSGAIEDGYVWGRGAVDMKDMVGMMIVVARHLRQAAIVPPRDLVFAFVADEEHGGK
YGSHWLVDNRPDLFDGITEAIGEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTA
RGRAGHGSMVHDQNAVTAVCEAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDS
PDLAGTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATAEAVVDCRVLPGRRAA
FEAEVDALIGPDVTREWVSDLPSYETTFDGDLVAAMNAAVLAVDPDGRTVPYMLSGGT
DAKAFARLGIRCFGFSPLRLPPDLDFTSLFHGVDERVPIDGLRFGTEVLTHLLTHC"
gene 2401987..2402072
/gene="leuU"
tRNA 2401987..2402072
/gene="leuU"
/product="tRNA-Leu"
/anticodon=(pos:2402020..2402022,aa:Leu,seq:gag)
/note="codon recognized: CUC; leuU, tRNA-Leu, anticodon
gag, length = 86"
gene complement(2402193..2402510)
/gene="parE2"
/locus_tag="Rv2142c"
CDS complement(2402193..2402510)
/codon_start=1
/transl_table=11
/gene="parE2"
/locus_tag="Rv2142c"
/product="Possible toxin ParE2"
/note="Rv2142c, (MTCY270.26), len: 105 aa. Possible
parE2,toxin, part of toxin-antitoxin (TA) operon with
Rv2142A (See Pandey and Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2142c"
/db_xref="EnsemblGenomes-Tr:CCP44917"
/db_xref="GOA:P9WHG5"
/db_xref="InterPro:IPR007712"
/db_xref="InterPro:IPR035093"
/db_xref="UniProtKB/Swiss-Prot:P9WHG5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44917.1"
/translation="MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKR
IPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAIDILAVRHGMENPNAVEAEISGR
TFE"
gene complement(2402507..2402722)
/gene="parD2"
/locus_tag="Rv2142A"
CDS complement(2402507..2402722)
/codon_start=1
/transl_table=11
/gene="parD2"
/locus_tag="Rv2142A"
/product="Possible antitoxin ParD2"
/note="Rv2142A, len: 71 aa. Possible parD2, antitoxin,
part of toxin-antitoxin (TA) operon with Rv2142c (See
Pandey and Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2142A"
/db_xref="EnsemblGenomes-Tr:CCP44918"
/db_xref="GOA:P9WJ75"
/db_xref="InterPro:IPR013406"
/db_xref="UniProtKB/Swiss-Prot:P9WJ75"
/protein_id="CCP44918.1"
/translation="MVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALI
EARANDTDDAHWSTIDDFDKRIRARLG"
gene 2402977..2404035
/locus_tag="Rv2143"
CDS 2402977..2404035
/codon_start=1
/transl_table=11
/locus_tag="Rv2143"
/product="Conserved hypothetical protein"
/note="Rv2143, (MTCY270.25c), len: 352 aa. Conserved
hypothetical protein, strongly similar to two hypothetical
mycobacterial proteins Rv2030c 2.1e-50 and Rv0571c from
position 120 (Q50819; Q50111). FASTA best: Q50819 opt:
882,E() 0; (61.1% identity in 226 aa overlap). Also
similar to AL021942|MTV039_9 (443 aa), FASTA scores: opt:
592, E(): 5e-30; 46.9% identity in 224 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2143"
/db_xref="EnsemblGenomes-Tr:CCP44919"
/db_xref="GOA:O06232"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR029057"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/TrEMBL:O06232"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44919.1"
/translation="MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADD
PAENESLLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGLLP
PGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLADELASYRGRD
RLLVLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWRELAMGALASGGGVVMNDD
VVSSLRITDQQVRAAIDSETAELQRRELAYRGGRPVVDPRARIVILVDDGIATGASML
AAVRTIRATGPESIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQV
TDDEVRELLATPTTGAAT"
gene complement(2404165..2404521)
/locus_tag="Rv2144c"
CDS complement(2404165..2404521)
/codon_start=1
/transl_table=11
/locus_tag="Rv2144c"
/product="Probable transmembrane protein"
/note="Rv2144c, (MTCY270.24), len: 118 aa. Probable
transmembrane protein. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004)."
/db_xref="EnsemblGenomes-Gn:Rv2144c"
/db_xref="EnsemblGenomes-Tr:CCP44920"
/db_xref="GOA:O06231"
/db_xref="UniProtKB/TrEMBL:O06231"
/protein_id="CCP44920.1"
/translation="MLIIALVLALIGLLALVFAVVTSNQLVAWVCIGASVLGVALLIV
DALRERQQGGADEADGAGETGVAEEADVDYPEEAPEESQAVDAGVIGSEEPSEEASEA
TEESAVSADRSDDSAK"
gene complement(2404616..2405398)
/gene="wag31"
/gene_synonym="ag84"
/locus_tag="Rv2145c"
CDS complement(2404616..2405398)
/codon_start=1
/transl_table=11
/gene="wag31"
/gene_synonym="ag84"
/locus_tag="Rv2145c"
/product="Diviva family protein Wag31"
/note="Rv2145c, (MTCY270.23), len: 260 aa. Wag31
(alternate gene name: ag84). Function unknown but
corresponds to antigen 84 of Mycobacterium tuberculosis
(wag31) (see Hermans et al., 1995). Predicted to contain
significant amount of coiled coil structure. Some
similarity to Rv1682 and Rv2927c. FASTA best: AG84_MYCTU
P46816 antigen 84. Wag31|Rv2145c and PbpB|Rv2163c have
been shown to interact; cleavage of PbpB|Rv2163c by
Rv2869c under conditions of oxidative stress is prevented
by Wag31|Rv2145c (See Mukherjee et al., 2009)."
/db_xref="EnsemblGenomes-Gn:Rv2145c"
/db_xref="EnsemblGenomes-Tr:CCP44921"
/db_xref="GOA:P9WMU1"
/db_xref="InterPro:IPR007793"
/db_xref="InterPro:IPR019933"
/db_xref="UniProtKB/Swiss-Prot:P9WMU1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44921.1"
/translation="MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVENELTRLIE
ENSDLRQRINELDQELAAGGGAGVTPQATQAIPAYEPEPGKPAPAAVSAGMNEEQALK
AARVLSLAQDTADRLTNTAKAESDKMLADARANAEQILGEARHTADATVAEARQRADA
MLADAQSRSEAQLRQAQEKADALQADAERKHSEIMGTINQQRAVLEGRLEQLRTFERE
YRTRLKTYLESQLEELGQRGSAAPVDSNADAGGFDQFNRGKN"
gene complement(2405666..2405956)
/locus_tag="Rv2146c"
CDS complement(2405666..2405956)
/codon_start=1
/transl_table=11
/locus_tag="Rv2146c"
/product="Possible conserved transmembrane protein"
/note="Rv2146c, (MTCY270.22), len: 96 aa. Possible
conserved transmembrane protein, orthologs present in M.
leprae, ML0921 (96 aa) and Streptomyces coelicolor. Second
start taken GTG alternative upstream but much less
probable in TBParse. FASTA best: Q44935 similar to a
hypothetical integral membrane prot EIN (97 aa) opt: 105,
E(): 0.093; (25.3% identity in 87 aa overlap).
>emb|CAC31302.1| (AL583920) possible membrane protein
ML0921 [Mycobacterium leprae] E(): 5e-32 (76% identity in
96 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2146c"
/db_xref="EnsemblGenomes-Tr:CCP44922"
/db_xref="GOA:O06230"
/db_xref="InterPro:IPR003425"
/db_xref="UniProtKB/TrEMBL:O06230"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44922.1"
/translation="MVVFFQILGFALFIFWLLLIARVVVEFIRSFSRDWRPTGVTVVI
LEIIMSITDPPVKVLRRLIPQLTIGAVRFDLSIMVLLLVAFIGMQLAFGAAA"
gene complement(2406118..2406843)
/locus_tag="Rv2147c"
CDS complement(2406118..2406843)
/codon_start=1
/transl_table=11
/locus_tag="Rv2147c"
/product="Conserved hypothetical protein"
/note="Rv2147c, (MTCY270.21), len: 241 aa. Conserved
hypothetical protein, similar to conserved hypothetical
proteins in Mycobacterium leprae ML0920 (210 aa) and
Streptomyces coelicolor. FASTA scores: >emb|CAC31301.1|
(AL583920) hypothetical protein ML0920 hypothetical
protein (210 aa) opt: 1242, E(): 5.7e-74; 83.486% identity
in 218 aa overlap. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2147c"
/db_xref="EnsemblGenomes-Tr:CCP44923"
/db_xref="GOA:P9WGJ5"
/db_xref="InterPro:IPR007561"
/db_xref="InterPro:IPR023052"
/db_xref="InterPro:IPR038594"
/db_xref="UniProtKB/Swiss-Prot:P9WGJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44923.1"
/translation="MNSHCSHTFITDNRSPRARRGHAMSTLHKVKAYFGMAPMEDYDD
EYYDDRAPSRGYARPRFDDDYGRYDGRDYDDARSDSRGDLRGEPADYPPPGYRGGYAD
EPRFRPREFDRAEMTRPRFGSWLRNSTRGALAMDPRRMAMMFEDGHPLSKITTLRPKD
YSEARTIGERFRDGSPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLS
PADVDVSPEERRRIAETGFYAYQ"
gene complement(2406840..2407616)
/locus_tag="Rv2148c"
CDS complement(2406840..2407616)
/codon_start=1
/transl_table=11
/locus_tag="Rv2148c"
/product="Conserved protein"
/note="Rv2148c, (MTCY270.20), len: 258 aa. Conserved
protein; should belong to the YGGS/YBL036C/F09E5.8 family.
FASTA best: AB003132|AB003132_5 Corynebacterium glutamicum
gene (221 aa) opt: 440, E(): 2.3e-23; 42.8% identity in
236 aa overlap; and YPI1_VIBAL P52055 hypothetical protein
in pilt-proc intergenic region in Vibrio alginolyticus.
opt: 266, E(): 1.8e-11; 27.9% identity in 244 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2148c"
/db_xref="EnsemblGenomes-Tr:CCP44924"
/db_xref="GOA:P9WFQ7"
/db_xref="InterPro:IPR001608"
/db_xref="InterPro:IPR011078"
/db_xref="InterPro:IPR029066"
/db_xref="UniProtKB/Swiss-Prot:P9WFQ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44924.1"
/translation="MAADLSAYPDRESELTHALAAMRSRLAAAAEAAGRNVGEIELLP
ITKFFPATDVAILFRLGCRSVGESREQEASAKMAELNRLLAAAELGHSGGVHWHMVGR
IQRNKAGSLARWAHTAHSVDSSRLVTALDRAVVAALAEHRRGERLRVYVQVSLDGDGS
RGGVDSTTPGAVDRICAQVQESEGLELVGLMGIPPLDWDPDEAFDRLQSEHNRVRAMF
PHAIGLSAGMSNDLEVAVKHGSTCVRVGTALLGPRRLRSP"
gene complement(2407622..2408374)
/gene="yfiH"
/locus_tag="Rv2149c"
CDS complement(2407622..2408374)
/codon_start=1
/transl_table=11
/gene="yfiH"
/locus_tag="Rv2149c"
/product="Conserved protein YfiH"
/note="Rv2149c, (MTCY270.19), len: 250 aa. YfiH;
corresponds to 25.3 kDa YfiH protein in ftsZ 3' region of
Streptomyces griseus, and to YfiH proteins in other
bacteria. Belongs to UPF0124 Family. FASTA best:
YFIH_STRGR P45496, (246 aa) opt: 722, E(): 1.9e-37; (49.4%
identity in 245 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2149c"
/db_xref="EnsemblGenomes-Tr:CCP44925"
/db_xref="GOA:P9WKD5"
/db_xref="InterPro:IPR003730"
/db_xref="InterPro:IPR011324"
/db_xref="InterPro:IPR038371"
/db_xref="UniProtKB/Swiss-Prot:P9WKD5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44925.1"
/translation="MLASTRHIARGDTGNVSVRIRRVTTTRAGGVSAPPFDTFNLGDH
VGDDPAAVAANRARLAAAIGLPGNRVVWMNQVHGDRVELVDQPRNTALDDTDGLVTAT
PRLALAVVTADCVPVLMADARAGIAAAVHAGRAGAQRGVVVRALEVMLSLGAQVRDIS
ALLGPAVSGRNYEVPAAMADEVEAALPGSRTTTAAGTPGVDLRAGIACQLRDLGVESI
DVDPRCTVADPTLFSHRRDAPTGRFASLVWME"
gene complement(2408385..2409524)
/gene="ftsZ"
/locus_tag="Rv2150c"
CDS complement(2408385..2409524)
/codon_start=1
/transl_table=11
/gene="ftsZ"
/locus_tag="Rv2150c"
/product="Cell division protein FtsZ"
/note="Rv2150c, (MTCY270.18), len: 379 aa. FtsZ, cell
division protein (see Dziadek et al., 2002). Contains FtsZ
protein signature 2 (PS01135). FASTA best: FTSZ_STRCO
P45500 cell division protein FtsZ (399 aa) opt: 1674, E():
0; (77.3% identity in 339 aa overlap). FtsW|Rv2154c
interacts with PbpB|Rv2163c and FtsZ|RvRv2150c (See Datta
et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv2150c"
/db_xref="EnsemblGenomes-Tr:CCP44926"
/db_xref="GOA:P9WN95"
/db_xref="InterPro:IPR000158"
/db_xref="InterPro:IPR003008"
/db_xref="InterPro:IPR008280"
/db_xref="InterPro:IPR018316"
/db_xref="InterPro:IPR020805"
/db_xref="InterPro:IPR024757"
/db_xref="InterPro:IPR036525"
/db_xref="InterPro:IPR037103"
/db_xref="PDB:1RLU"
/db_xref="PDB:1RQ2"
/db_xref="PDB:1RQ7"
/db_xref="PDB:2Q1X"
/db_xref="PDB:2Q1Y"
/db_xref="PDB:4KWE"
/db_xref="PDB:5V68"
/db_xref="PDB:5ZUE"
/db_xref="UniProtKB/Swiss-Prot:P9WN95"
/inference="protein motif:PROSITE:PS01135"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44926.1"
/translation="MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDA
QALLMSDADVKLDVGRDSTRGLGAGADPEVGRKAAEDAKDEIEELLRGADMVFVTAGE
GGGTGTGGAPVVASIARKLGALTVGVVTRPFSFEGKRRSNQAENGIAALRESCDTLIV
IPNDRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGA
GTALMGIGSARGEGRSLKAAEIAINSPLLEASMEGAQGVLMSIAGGSDLGLFEINEAA
SLVQDAAHPDANIIFGTVIDDSLGDEVRVTVIAAGFDVSGPGRKPVMGETGGAHRIES
AKAGKLTSTLFEPVDAVSVPLHTNGATLSIGGDDDDVDVPPFMRR"
gene complement(2409697..2410641)
/gene="ftsQ"
/locus_tag="Rv2151c"
CDS complement(2409697..2410641)
/codon_start=1
/transl_table=11
/gene="ftsQ"
/locus_tag="Rv2151c"
/product="Possible cell division protein FtsQ"
/note="Rv2151c, (MTCY270.17), len: 314 aa. Possible
ftsQ,cell division protein, with some homology to
FTSQ_STRGR|P45503 cell division protein ftsq homolog from
Streptomyces griseus (208 aa), FASTA scores: opt: 204,
E(): 4e-05; (30.6% identity in 193 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2151c"
/db_xref="EnsemblGenomes-Tr:CCP44927"
/db_xref="GOA:P9WNA1"
/db_xref="InterPro:IPR005548"
/db_xref="InterPro:IPR013685"
/db_xref="InterPro:IPR026579"
/db_xref="InterPro:IPR034746"
/db_xref="UniProtKB/Swiss-Prot:P9WNA1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44927.1"
/translation="MTEHNEDPQIERVADDAADEEAVTEPLATESKDEPAEHPEFEGP
RRRARRERAERRAAQARATAIEQARRAAKRRARGQIVSEQNPAKPAARGVVRGLKALL
ATVVLAVVGIGLGLALYFTPAMSAREIVIIGIGAVSREEVLDAARVRPATPLLQIDTQ
QVADRVATIRRVASARVQRQYPSALRITIVERVPVVVKDFSDGPHLFDRDGVDFATDP
PPPALPYFDVDNPGPSDPTTKAALQVLTALHPEVASQVGRIAAPSVASITLTLADGRV
VIWGTTDRCEEKAEKLAALLTQPGRTYDVSSPDLPTVK"
gene complement(2410638..2412122)
/gene="murC"
/locus_tag="Rv2152c"
CDS complement(2410638..2412122)
/codon_start=1
/transl_table=11
/gene="murC"
/locus_tag="Rv2152c"
/product="Probable UDP-N-acetylmuramate-alanine ligase
MurC"
/note="Rv2152c, (MTCY270.16), len: 494 aa. Probable
murC,UDP-N-acetylmuramate-alanine ligase (see citation
below),similar to others e.g. MURC_ECOLI|P17952 (491 aa),
FASTA scores: opt: 764, E(): 0, (36.9% identity in 474 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2152c"
/db_xref="EnsemblGenomes-Tr:CCP44928"
/db_xref="GOA:P9WJL7"
/db_xref="InterPro:IPR000713"
/db_xref="InterPro:IPR004101"
/db_xref="InterPro:IPR005758"
/db_xref="InterPro:IPR013221"
/db_xref="InterPro:IPR036565"
/db_xref="InterPro:IPR036615"
/db_xref="UniProtKB/Swiss-Prot:P9WJL7"
/protein_id="CCP44928.1"
/translation="MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKE
SRGVHALRARGALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVV
LRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAH
HGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVP
GGALVVCTDDPGGAALAQRATELGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRL
ASELATAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVLDGLAGFEGVRRRFE
LVGTCGVGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKA
FAAEFGRALNAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVA
AAASPGDVIVTMGAGDVTLLGPEILTALRVRANRSAPGRPGVLG"
gene complement(2412119..2413351)
/gene="murG"
/locus_tag="Rv2153c"
CDS complement(2412119..2413351)
/codon_start=1
/transl_table=11
/gene="murG"
/locus_tag="Rv2153c"
/product="Probable UPD-N-acetylglucosamine-N-
acetylmuramyl-(pentapeptide)
pyrophosphoryl-undecaprenol-N-acetylglucosamine
transferase MurG"
/note="Rv2153c, (MTCY270.15), len: 410 aa. Probable murG,
UPD-N-acetylglucosamine-N-acetylmuramyl-
(pentapeptide)pyrophosphoryl-undecaprenol-N-
acetylglucosamine transferase (see citation below),
similar to others e.g. MURG_BACSU[P37585 murg protein from
Bacilus subtilis (363 aa), FASTA score: opt: 494, E():
1.1e-20, (27.9% identity in 365 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2153c"
/db_xref="EnsemblGenomes-Tr:CCP44929"
/db_xref="GOA:P9WJK9"
/db_xref="InterPro:IPR004276"
/db_xref="InterPro:IPR006009"
/db_xref="InterPro:IPR007235"
/db_xref="UniProtKB/Swiss-Prot:P9WJK9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44929.1"
/translation="MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSVSVVLAGGG
TAGHVEPAMAVADALVALDPRVRITALGTLRGLETRLVPQRGYHLELITAVPMPRKPG
GDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIP
VVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAE
ARAHFGFPDDARVLLVFGGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRR
RAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQ
RLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQ
VARAALAVATGAGARTTT"
gene complement(2413348..2414922)
/gene="ftsW"
/locus_tag="Rv2154c"
CDS complement(2413348..2414922)
/codon_start=1
/transl_table=11
/gene="ftsW"
/locus_tag="Rv2154c"
/product="FtsW-like protein FtsW"
/note="Rv2154c, (MTCY270.14), len: 524 aa. Probable
ftsW,cell division protein, related to MTCY10H4.17c,
3.2e-17. FASTA best: SP5E_BACSU P07373 stage V sporulation
protein E (366 aa) opt: 755, E(): 1.6e-33; (38.4% identity
in 357 aa overlap). FtsW|Rv2154c interacts with
PbpB|Rv2163c and FtsZ|RvRv2150c (See Datta et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv2154c"
/db_xref="EnsemblGenomes-Tr:CCP44930"
/db_xref="GOA:P9WN97"
/db_xref="InterPro:IPR001182"
/db_xref="InterPro:IPR013437"
/db_xref="InterPro:IPR018365"
/db_xref="UniProtKB/Swiss-Prot:P9WN97"
/protein_id="CCP44930.1"
/translation="MLTRLLRRGTSDTDGSQTRGAEPVEGQRTGPEEASNPGSARPRT
RFGAWLGRPMTSFHLIIAVAALLTTLGLIMVLSASAVRSYDDDGSAWVIFGKQVLWTL
VGLIGGYVCLRMSVRFMRRIAFSGFAITIVMLVLVLVPGIGKEANGSRGWFVVAGFSM
QPSELAKMAFAIWGAHLLAARRMERASLREMLIPLVPAAVVALALIVAQPDLGQTVSM
GIILLGLLWYAGLPLRVFLSSLAAVVVSAAILAVSAGYRSDRVRSWLNPENDPQDSGY
QARQAKFALAQGGIFGDGLGQGVAKWNYLPNAHNDFIFAIIGEELGLVGALGLLGLFG
LFAYTGMRIASRSADPFLRLLTATTTLWVLGQAFINIGYVIGLLPVTGLQLPLISAGG
TSTAATLSLIGIIANAARHEPEAVAALRAGRDDKVNRLLRLPLPEPYLPPRLEAFRDR
KRANPQPAQTQPARKTPRTAPGQPARQMGLPPRPGSPRTADPPVRRSVHHGAGQRYAG
QRRTRRVRALEGQRYG"
gene complement(2414934..2416394)
/gene="murD"
/locus_tag="Rv2155c"
CDS complement(2414934..2416394)
/codon_start=1
/transl_table=11
/gene="murD"
/locus_tag="Rv2155c"
/product="Probable UDP-N-acetylmuramoylalanine-D-glutamate
ligase MurD"
/note="Rv2155c, (MTCY270.13), len: 486 aa. Probable
murD,UDP-N-acetylmuramoylalanine-D-glutamate ligase (see
citation below), similar to others e.g. MURD_BACSU|Q03522
(451 aa), FASTA scores: opt: 534, E(): 2.7e-25, (28.8%
identity in 483 aa overlap); etc. Contains PS01011
Folylpolyglutamate synthase signature 1."
/db_xref="EnsemblGenomes-Gn:Rv2155c"
/db_xref="EnsemblGenomes-Tr:CCP44931"
/db_xref="GOA:P9WJL5"
/db_xref="InterPro:IPR004101"
/db_xref="InterPro:IPR005762"
/db_xref="InterPro:IPR013221"
/db_xref="InterPro:IPR036565"
/db_xref="InterPro:IPR036615"
/db_xref="UniProtKB/Swiss-Prot:P9WJL5"
/inference="protein motif:PROSITE:PS01011"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44931.1"
/translation="MLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVML
RPHAERGLPTVSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWR
LDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPA
ELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAG
LDDSRAAALLDGSPAQVRVGFRLGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVP
GPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATN
PHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRH
APDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQ
PGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR"
gene complement(2416396..2417475)
/gene="murX"
/locus_tag="Rv2156c"
CDS complement(2416396..2417475)
/codon_start=1
/transl_table=11
/gene="murX"
/locus_tag="Rv2156c"
/product="Probable phospho-N-acetylmuramoyl-
pentappeptidetransferase MurX"
/note="Rv2156c, (MTCY270.12), len: 359 aa. Probable
murX,phospho-N-acetylmuramoyl-pentappeptidetransferase
(see citation below), similar to others
e.g.MRAY_ECOLI|P15876 (360 aa), FASTA scores: opt: 572,
E(): 2.7e-29, (35.8% identity in 344 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2156c"
/db_xref="EnsemblGenomes-Tr:CCP44932"
/db_xref="GOA:P9WMW7"
/db_xref="InterPro:IPR000715"
/db_xref="InterPro:IPR003524"
/db_xref="InterPro:IPR018480"
/db_xref="UniProtKB/Swiss-Prot:P9WMW7"
/protein_id="CCP44932.1"
/translation="MRQILIAVAVAVTVSILLTPVLIRLFTKQGFGHQIREDGPPSHH
TKRGTPSMGGVAILAGIWAGYLGAHLAGLAFDGEGIGASGLLVLGLATALGGVGFIDD
LIKIRRSRNLGLNKTAKTVGQITSAVLFGVLVLQFRNAAGLTPGSADLSYVREIATVT
LAPVLFVLFCVVIVSAWSNAVNFTDGLDGLAAGTMAMVTAAYVLITFWQYRNACVTAP
GLGCYNVRDPLDLALIAAATAGACIGFLWWNAAPAKIFMGDTGSLALGGVIAGLSVTS
RTEILAVVLGALFVAEITSVVLQILTFRTTGRRMFRMAPFHHHFELVGWAETTVIIRF
WLLTAITCGLGVALFYGEWLAAVGA"
gene complement(2417472..2419004)
/gene="murF"
/locus_tag="Rv2157c"
CDS complement(2417472..2419004)
/codon_start=1
/transl_table=11
/gene="murF"
/locus_tag="Rv2157c"
/product="Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-
2, 6-diaminopimelate-D-alanyl-D-alanyl ligase MurF"
/note="Rv2157c, (MTCY270.11), len: 510 aa. Probable
murF,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
6-diaminopimelate-D-alanyl-D-alanyl ligase
(UDP-murnac-pentapeptide synthetase) (see citation below),
also related to other Mycobacterium tuberculosis mur gene
products. FASTA best: MURF_ECOLI|P11880 (452 aa),opt: 515,
E(): 2.6e-24, (31.9% identity in 511 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2157c"
/db_xref="EnsemblGenomes-Tr:CCP44933"
/db_xref="GOA:P9WJL1"
/db_xref="InterPro:IPR000713"
/db_xref="InterPro:IPR004101"
/db_xref="InterPro:IPR005863"
/db_xref="InterPro:IPR013221"
/db_xref="InterPro:IPR035911"
/db_xref="InterPro:IPR036565"
/db_xref="InterPro:IPR036615"
/db_xref="UniProtKB/Swiss-Prot:P9WJL1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44933.1"
/translation="MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPG
GLFLALPGARADGHDHAASAVAAGAAVVLAARPVGVPAIVVPPVAAPNVLAGVLEHDN
DGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPLGEVVAP
PGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHL
GEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVW
AGPVSLDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAA
LTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQPEATRRSWAV
LGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGAVLEGAWGSGEAT
ADHGADRTAVNVADGDAALALLRAELRPGDVVLVKASNAAGLGAVADALVADDTCGSV
RP"
gene complement(2419001..2420608)
/gene="murE"
/locus_tag="Rv2158c"
CDS complement(2419001..2420608)
/codon_start=1
/transl_table=11
/gene="murE"
/locus_tag="Rv2158c"
/product="Probable UDP-N-acetylmuramoylalanyl-D-glutamate-
2,6-diaminopimelate ligase MurE"
/note="Rv2158c, (MTCY270.10), len: 535 aa. Probable
murE,UDP-N-acetylmuramoylalanyl-D-glutamate-2,
6-diaminopimelate ligase; UDP-N-acetylmuramyl-tripeptide
synthetase (see citation below), also related to other
Mycobacterium tuberculosis mur gene products. FASTA best:
MURE_BACSU|Q03523 (494 aa), opt: 1020, E(): 0, (40.1%
identity in 476 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2158c"
/db_xref="EnsemblGenomes-Tr:CCP44934"
/db_xref="GOA:P9WJL3"
/db_xref="InterPro:IPR000713"
/db_xref="InterPro:IPR004101"
/db_xref="InterPro:IPR005761"
/db_xref="InterPro:IPR013221"
/db_xref="InterPro:IPR035911"
/db_xref="InterPro:IPR036565"
/db_xref="InterPro:IPR036615"
/db_xref="PDB:2WTZ"
/db_xref="PDB:2XJA"
/db_xref="UniProtKB/Swiss-Prot:P9WJL3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44934.1"
/translation="MSSLARGISRRRTEVATQVEAAPTGLRPNAVVGVRLAALADQVG
AALAEGPAQRAVTEDRTVTGVTLRAQDVSPGDLFAALTGSTTHGARHVGDAIARGAVA
VLTDPAGVAEIAGRAAVPVLVHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTT
TYLVEAGLRAAGRVAGLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVV
MEVSSHALALGRVDGTRFAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSALRART
AVVCIDDDAGRAMAARAADAITVSAADRPAHWRATDVAPTDAGGQQFTAIDPAGVGHH
IGIRLPGRYNVANCLVALAILDTVGVSPEQAVPGLREIRVPGRLEQIDRGQGFLALVD
YAHKPEALRSVLTTLAHPDRRLAVVFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNP
RDEDPTAIRREILAGAAEVGGDAQVVEIADRRDAIRHAVAWARPGDVVLIAGKGHETG
QRGGGRVRPFDDRVELAAALEALERRA"
gene complement(2420631..2421665)
/locus_tag="Rv2159c"
CDS complement(2420631..2421665)
/codon_start=1
/transl_table=11
/locus_tag="Rv2159c"
/product="Conserved protein"
/note="Rv2159c, (MTCY270.09), len: 344 aa. Conserved
protein; some similarity to hypothetical protein from
Streptomyces coelicolor SC1A6.09c (337 aa, 29% identity).
Smith-Waterman scores: >pir||T28690 hypothetical protein
-Streptomyces coelicolor >gi|3127841|emb|CAA18907.1|
(AL023496) Expect = 2e-18. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2159c"
/db_xref="EnsemblGenomes-Tr:CCP44935"
/db_xref="GOA:O06218"
/db_xref="InterPro:IPR003779"
/db_xref="InterPro:IPR004675"
/db_xref="InterPro:IPR029032"
/db_xref="UniProtKB/TrEMBL:O06218"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44935.1"
/translation="MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDE
GLLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAA
AILAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLV
LLDETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSE
PIATAFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLH
APTRLALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAE
GQVSRQNPTG"
gene complement(2421643..2422278)
/locus_tag="Rv2160A"
CDS complement(2421643..2422278)
/codon_start=1
/transl_table=11
/locus_tag="Rv2160A"
/product="Conserved hypothetical protein"
/note="Rv2160A, len: 211 aa. Conserved hypothetical
protein, possibly a TetR-family transcriptional
regulator,similar to N-terminal half of
AL512667_12|Q9AD73|SCK31.01c putative TetR-family
transcriptional regulator from Streptomyces coelicolor
(200 aa), FASTA scores: opt: 285,E(): 1.4e-08, (51.042%
identity in 96 aa overlap). Next gene, Rv2160c, is similar
to C-terminal half of 2SCK31.01c suggesting possible
frameshift near 2421978 but sequence of this region has
been checked and is also identical in strain CDC1551. This
region is a possible MT-complex-specific genomic island
(See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2160A"
/db_xref="EnsemblGenomes-Tr:CCP44936"
/db_xref="GOA:L0TBP1"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:L0TBP1"
/protein_id="CCP44936.1"
/translation="MPSADVGRQTRAQILRAAMDIASVKGLSGLSIGELAGRLGMSKS
GLFRHFGAKEQLQLATVEAAVSVFEAEVVAPAMAAPPGVDRVRALMHAWVGYLERDVP
AAAFSRPRPPTWTHSLARCATASPRPGGPESPPSRPTSKRRNAGARSGRISKCANSRS
SCTPTRWRPTGRCCCSTTTAPESGRERRSTRPWPESAPPRRESNHEICQPY"
gene complement(2421662..2422003)
/locus_tag="Rv2160c"
CDS complement(2421662..2422003)
/codon_start=1
/transl_table=11
/locus_tag="Rv2160c"
/product="Conserved hypothetical protein"
/note="Rv2160c, (MTCY270.08), len: 113 aa. Conserved
hypothetical protein, possibly a TetR-family
transcriptional regulator, similar to C-terminal half of
AL512667_12|Q9AD73|SCK31.01c putative TetR-family
transcriptional regulator from Streptomyces coelicolor
(200 aa), while Rv2160A is similar to the N-terminal half
of 2SCK31.01c. This suggests possible frameshift near
2421978 but sequence of this region has been checked and
is also identical in strain CDC1551. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2160c"
/db_xref="EnsemblGenomes-Tr:CCP44937"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:Q79FG9"
/protein_id="CCP44937.1"
/translation="MGRIPGTRRAGGCFFAAAAADVDSQPGPVRDRIAATGRAGIAAI
TADVETAQRRGEIRADIEVRQLAFELHAYAMEANWALLLLDDDGAGERARTAIDAALA
RVGTTQEGVES"
gene complement(2422271..2423137)
/locus_tag="Rv2161c"
CDS complement(2422271..2423137)
/codon_start=1
/transl_table=11
/locus_tag="Rv2161c"
/product="Conserved protein"
/note="Rv2161c, (MTCY270.07), len: 288 aa. Conserved
protein; shows some similarity to protein involved in
lincomycin production and to other M. tuberculosis
proteins e.g. Rv0953c, Rv0791c, Rv0132c, Rv2951c, Rv1855c.
FASTA best: Q54379 (78-11) lincomycin production genes
(295 aa) opt: 243, E(): 2.4e-09; (29.5% identity in 285 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2161c"
/db_xref="EnsemblGenomes-Tr:CCP44938"
/db_xref="GOA:O06216"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019921"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:O06216"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44938.1"
/translation="MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRS
TPWPGGELPDWYRRCYDPVVALAAAAAVTTRLRVGTGACLVAVHDPILLAKQIASLCA
MSGERFVLGVGFGWNVEELADHGVPFADRIAVTVDKLAAMRALWAAEPVHYEGTHASV
PPSWAWPKPAVAPPVLFGCRPSARAFEVIARHGDGWQPIEGYGELLGALPMLHAAFER
AGRDPATAQVCVYSSAGDPATLHEYRRAGVAEVALALPSAGRDQVLAALDRSAPLVDA
FAGDDREVKSHA"
gene complement(2423240..2424838)
/gene="PE_PGRS38"
/locus_tag="Rv2162c"
CDS complement(2423240..2424838)
/codon_start=1
/transl_table=11
/gene="PE_PGRS38"
/locus_tag="Rv2162c"
/product="PE-PGRS family protein PE_PGRS38"
/note="Rv2162c, (MTCY270.06), len: 532 aa.
PE_PGRS38,Member of M. tuberculosis PE_PGRS family (see
citations below). FASTA score: Y03A_MYCTU Q 10637
hypothetical glycine-rich 49.6 kDa protein (603 aa) op t:
1798 z-score: 1220.0 E(): 0; (55.4% identity in 590 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2162c"
/db_xref="EnsemblGenomes-Tr:CCP44939"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N6A1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44939.1"
/translation="MSFVIAAPEVMAAAATDLANIGSSISAASAAAAGPTMGILAAGA
DEVSVAISALFGSHAQGYQTLSAQLAAYHNQFVRALNAGAGSYASAEAANVQQTLLNA
INAPTQTLLGRPLIGNGADGGPGQNGGPGGLLYGNGGNGGAGDTANPNGGNGGSAGLI
GNGGAGGAGAATGAGGAGGNGGWLYGNGGPGGAAGLGTAGGVSPAGGAGGAAGLWGHG
GAGGAGGSASGAPGAGGAGGDGGRGGLLYGDGGAGGAGGNGSNGVTGVHGGNGGAGGA
AGLIGNGGAGGDGGNGGLSNTGASGGAGGAGGAALIGNGGDGGHGGNGGHGNSGGAGG
AGGAGGAGGAGGHVGLIGNGGNGGAGGNGGNDNSSTLADAGSGGAGAAGGNGGLFYGN
GGVGGRGGNGGFSSAGTSGGDGGIGGAGGIGGLIGSGGGGGDGGNGGQAPTPGNAGDG
GAGGNARLIGDGGRGGNGGEGGDGPPGVKGDGGNGGNGGNAVVIGNGGNGGAGGFGIP
VGSGGAGGSRGVLFGTPGANGADG"
gene complement(2425048..2427087)
/gene="pbpB"
/gene_synonym="ftsI"
/locus_tag="Rv2163c"
CDS complement(2425048..2427087)
/codon_start=1
/transl_table=11
/gene="pbpB"
/gene_synonym="ftsI"
/locus_tag="Rv2163c"
/product="Probable penicillin-binding membrane protein
PbpB"
/note="Rv2163c, (MTCY270.05), len: 679 aa. Probable
pbpB,penicillin-binding membrane protein, similar to many
bacterial PBP2 proteins e.g.
P11882|PBP2_NEIME|PENA|NMA2072|NMB0413 penicillin-binding
protein 2 (pbp-2) from Neisseria meningitidis (serogroups
a and B) (581 aa), FASTA scores: opt: 665, E():
1.6e-31,(33.2% identity in 591 aa overlap); etc. Also
similar to Rv0016c and Rv2864c from Mycobacterium
tuberculosis (2.8e-10). Contains PS00017 possible
ATP/GTP-binding site motif A (P-loop) near C-terminus.
FASTA best: PBP2_NEIME P11882 penicillin-binding protein 2
(pbp-2). (581 aa) opt: 665, E(): 1.6e-31; (33.2% identity
in 591 aa overlap). FtsW|Rv2154c interacts with
PbpB|Rv2163c and FtsZ|RvRv2150c (See Datta et al., 2006).
Cleavage of PbpB|Rv2163c by Rv2869c under conditions of
oxidative stress is prevented by Wag31|Rv2145c (See
Mukherjee et al., 2009)."
/db_xref="EnsemblGenomes-Gn:Rv2163c"
/db_xref="EnsemblGenomes-Tr:CCP44940"
/db_xref="GOA:L0T911"
/db_xref="InterPro:IPR001460"
/db_xref="InterPro:IPR005311"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR036138"
/db_xref="UniProtKB/Swiss-Prot:L0T911"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44940.1"
/translation="MSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQ
AQEATKSRPATRSDVAPAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVA
ATQLFFLQVSHAAGLRAQAAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPK
RIRRQLEEARKKTSAAPDPQQRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLAR
AVDPAVASAICAKYPEVGAERQDLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVL
AGTDGSVTYDRGSDGVVIPGSYRNRHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSG
AHNVSAVVLDAKTGEVLAMANDNTFDPSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVA
ASAVIEHGLSSPDEVLQVPGSIQMGGVTVHDAWEHGVMPYTTTGVFGKSSNVGTLMLS
QRVGPERYYDMLRKFGLGQRTGVGLPGESAGLVPPIDQWSGSTFANLPIGQGLSMTLL
QMTGMYQAIANDGVRVPPRIIKATVAPDGSRTEEPRPDDIRVVSAQTAQTVRQMLRAV
VQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQINPGCGCYFDDVYWITFAGIATADNP
RYVIGIMLDNPARNSDGAPGHSAAPLFHNIAGWLMQRENVPLSPDPGPPLVLQAT"
gene complement(2427084..2428238)
/locus_tag="Rv2164c"
CDS complement(2427084..2428238)
/codon_start=1
/transl_table=11
/locus_tag="Rv2164c"
/product="Probable conserved proline rich membrane
protein"
/note="Rv2164c, (MTCY270.04), len: 384 aa. Probable
pro-rich conserved membrane protein, equivalent to
ML0907|AL022602 putative conserved membrane protein from
Mycobacterium leprae (377 aa) (AL022602), FASTA scores:
opt: 1495, E(): 1.7e-56, (62.217% identity in 397 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2164c"
/db_xref="EnsemblGenomes-Tr:CCP44941"
/db_xref="GOA:O06213"
/db_xref="UniProtKB/TrEMBL:O06213"
/protein_id="CCP44941.1"
/translation="MRAKREAPKSRSSDRRRRADSPAAATRRTTTNSAPSRRIRSRAG
KTSAPGRQARVSRPGPQTSPMLSPFDRPAPAKNTSQAKARAKARKAKAPKLVRPTPME
RLAARLTSIDLRPRTLANKVPFVVLVIGSLGVGLGLTLWLSTDAAERSYQLSNARERT
RMLQQHKEALERDVREAASAPALAEAARRQGMIPTRDTAHLVQDPDGNWVVVGTPKPA
DGVPPPPLNTKLPEDPPPPPKPAAVPLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGT
ATLGGATHLPTQAGPQLPGPVPIPGAPGPMPAPPLGAVPSPAPAENPVPLQVGAAPPA
GLPGPAPVAATPGLSGGSQPMVAPPAPVPANGEQFGPVTAPVPTAPGAPR"
gene complement(2428235..2429425)
/locus_tag="Rv2165c"
CDS complement(2428235..2429425)
/codon_start=1
/transl_table=11
/locus_tag="Rv2165c"
/product="Conserved protein"
/note="Rv2165c, (MTCY270.03), len: 396 aa. Conserved
protein; shows strong similarity to several hypothetical
bacterial proteins but has extra 80 aa residues at
N-terminus FASTA best: YLXA_BACSU Q07876 hypothetical 35.3
kDa protein in ftsl (311 aa) opt: 781, E(): 0; (45.6%
identity in 296 aa overlap), belongs to the YABC
(E.coli),YLXA (B.subtilis) family"
/db_xref="EnsemblGenomes-Gn:Rv2165c"
/db_xref="EnsemblGenomes-Tr:CCP44942"
/db_xref="GOA:P9WJP1"
/db_xref="InterPro:IPR002903"
/db_xref="InterPro:IPR023397"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WJP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44942.1"
/translation="MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTA
CQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGG
HAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYA
AVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAAL
ADILRRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRT
FQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATP
AGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATE
KGDS"
gene complement(2429427..2429858)
/locus_tag="Rv2166c"
CDS complement(2429427..2429858)
/codon_start=1
/transl_table=11
/locus_tag="Rv2166c"
/product="Conserved protein"
/note="Rv2166c, (MTCY270.02), len: 143 aa. Conserved
protein; shows strong similarity to several hypothetical
bacterial proteins such as YLLB_BACSU P55343. Is
equivalent to Mycobacterium leprae hypothetical protein
ML0905 (143 aa, 92% identity) MLCB268.11c
>sp|O69561|YL66_MYCLE hypothetical 16.1 KDA protein ML0905
>gi|3080482|emb|CAA18677.1|(AL022602)
>gi|13092975|emb|CAC31286.1|(AL583920). FASTA scores:
ML0905|ML0905 conserved hypothetical protein (143 aa) opt:
873, E(): 3.1e-52; 92.254% identity in 142 aa overlap;
YLLB_BACSU P55343 hypothetical 16.6 kDa protein (143 aa)
opt: 340, E(): 3.6e-17; (35.0% identity in 143 aa
overlap). Belongs to the YABB (E.coli), YLLB (B.subtilis),
MG221 (M.genitalium) family"
/db_xref="EnsemblGenomes-Gn:Rv2166c"
/db_xref="EnsemblGenomes-Tr:CCP44943"
/db_xref="GOA:P9WJN9"
/db_xref="InterPro:IPR003444"
/db_xref="InterPro:IPR007159"
/db_xref="InterPro:IPR020603"
/db_xref="InterPro:IPR035642"
/db_xref="InterPro:IPR035644"
/db_xref="InterPro:IPR037914"
/db_xref="InterPro:IPR038619"
/db_xref="UniProtKB/Swiss-Prot:P9WJN9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44943.1"
/translation="MFLGTYTPKLDDKGRLTLPAKFRDALAGGLMVTKSQDHSLAVYP
RAAFEQLARRASKAPRSNPEARAFLRNLAAGTDEQHPDSQGRITLSADHRRYASLSKD
CVVIGAVDYLEIWDAQAWQNYQQIHEENFSAASDEALGDIF"
mobile_element complement(2430117..2431471)
/mobile_element_type="insertion sequence:IS6110-6"
/note="IS6110-6, len: 1355 nt. Insertion sequence IS6110."
repeat_region complement(2430117..2430144)
/note="28 bp Inverted repeat at the left end of IS6110;
GAGTCTCCGGACTCACCGGGGCGGTTCA"
gene complement(2430159..>2431145)
/locus_tag="Rv2167c"
CDS complement(2430159..>2431145)
/codon_start=1
/transl_table=11
/locus_tag="Rv2167c"
/product="Probable transposase"
/note="Rv2167c, (MTCY270.01), len: 328 aa. Probable IS6110
transposase. Identical to many other M. tuberculosis
IS6110 transposase subunits. The transposase described
here may be made by a frame shifting mechanism during
translation that fuses Rv2167c and Rv2168c, the sequence
UUUUAAAG (directly upstream of Rv2167c) maybe responsible
for such a frameshifting event (see McAdam et al., 1990).
Start changed since first submission (- 18 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2167c"
/db_xref="EnsemblGenomes-Tr:CCP44944"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP44944.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
gene complement(2431094..2431420)
/locus_tag="Rv2168c"
CDS complement(2431094..2431420)
/codon_start=1
/transl_table=11
/locus_tag="Rv2168c"
/product="Putative transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv2168c, (MTV021.01c), len: 108 aa. Putative
transposase for IS6110 (fragment), identical to many other
Mycobacterium tuberculosis IS6110 transposase subunits
e.g. Q50686|YIA4_MYCTU Insertion element IS6110
hypothetical 12.0 kDa protein (108 aa), fasta scores: E():
1.4e-43,(100.00% identity in 108 aa overlap). The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv2167c and
Rv2168c, the sequence UUUUAAAG (directly upstream of
Rv2167c) maybe responsible for such a frameshifting event
(see McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv2168c"
/db_xref="EnsemblGenomes-Tr:CCP44945"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP44945.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
repeat_region complement(2431444..2431471)
/note="28 bp Inverted repeat at the right end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene complement(2431565..2431969)
/locus_tag="Rv2169c"
CDS complement(2431565..2431969)
/codon_start=1
/transl_table=11
/locus_tag="Rv2169c"
/product="Probable conserved transmembrane protein"
/note="Rv2169c, (MTV021.02c), len: 134 aa. Probable
conserved transmembrane protein, with orthologs in M.
leprae, ML0904 probable membrane protein (134 aa), and
Streptomyces coelicolor. FASTA scores with ML0904, opt:
767, E(): 5.1e-43; 86.567% identity in 134 aa overlap.
emb|CAA18678.1| (AL022602) >gi|13092974|emb|CAC31285.1|
(AL583920). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2169c"
/db_xref="EnsemblGenomes-Tr:CCP44946"
/db_xref="GOA:O53503"
/db_xref="InterPro:IPR021401"
/db_xref="UniProtKB/TrEMBL:O53503"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44946.1"
/translation="MPLSDHEQRMLDQIESALYAEDPKFASSVRGGGFRAPTARRRLQ
GAALFIIGLGMLVSGVAFKETMIGSFPILSVFGFVVMFGGVVYAITGPRLSGRMDRGG
SAAGASRQRRTKGAGGSFTSRMEDRFRRRFDE"
gene 2432235..2432855
/locus_tag="Rv2170"
CDS 2432235..2432855
/codon_start=1
/transl_table=11
/locus_tag="Rv2170"
/product="GCN5-related N-acetyltransferase"
/note="Rv2170, (MTV021.03), len: 206 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain in C-terminal part. See
Vetting et al. 2005. Equivalent to hypothetical protein
ML0903 (210 aa) from Mycobacterium leprae. FASTA scores:
ML0903 conserved hypothetical protein (210 aa) opt: 1045,
E(): 9.1e-57; 77.143% identity in 210 aa overlap.
>emb|CAA18679.1| (AL022602) >gi|13092973|emb|CAC31284.1|
(AL583920). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2170"
/db_xref="EnsemblGenomes-Tr:CCP44947"
/db_xref="GOA:O53504"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR013653"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:O53504"
/protein_id="CCP44947.1"
/translation="MAIFLIDLPPSDMERRLGDALTVYVDAMRYPRGTETLRAPMWLE
HIRRRGWQAVAAVEVTAAEQAEAADTTALPSAAELSNAPMLGVAYGYPGAPGQWWQQQ
VVLGLQRSGFPRLAIARLMTSYFELTELHILPRAQGRGLGEALARRLLAGRDEDNVLL
STPETNGEDNRAWRLYRRLGFTDIIRGYHFAGDPRAFAILGRTLPL"
gene 2432951..2433634
/gene="lppM"
/locus_tag="Rv2171"
CDS 2432951..2433634
/codon_start=1
/transl_table=11
/gene="lppM"
/locus_tag="Rv2171"
/product="Probable conserved lipoprotein LppM"
/note="Rv2171, (MTV021.04), len: 227 aa. Probable
lppM,conserved lipoprotein; contains putative signal
peptide and appropriately positioned PS00013 Prokaryotic
membrane lipoprotein lipid attachment site. Has
hydrophobic stretch at C-terminus and also contains
PS00225 Crystallins beta and gamma 'Greek key' motif
signature. Unknown but equivalent to Mycobacterium leprae
lipoprotein ML0902 (239 aa). FASTA scores: opt: 1083, E():
2.4e-56; 75.446% identity in 224 aa overlap (5-227:16-239)
>emb|CAA18680.1| (AL022602) >gi|13092972|emb|CAC31283.1|
(AL583920). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2171"
/db_xref="EnsemblGenomes-Tr:CCP44948"
/db_xref="GOA:O53505"
/db_xref="PDB:2NC8"
/db_xref="UniProtKB/Swiss-Prot:O53505"
/inference="protein motif:PROSITE:PS00013"
/inference="protein motif:PROSITE:PS00225"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44948.1"
/translation="MARTRRRGMLAIAMLLMLVPLATGCLRVRASITISPDDLVSGEI
IAAAKPKNSKDTGPALDGDVPFSQKVAVSNYDSDGYVGSQAVFSDLTFAELPQLANMN
SDAAGVNLSLRRNGNIVILEGRADLTSVSDPDADVELTVAFPAAVTSTNGDRIEPEVV
QWKLKPGVVSTMSAQARYTDPNTRSFTGAGIWLGIAAFAAAGVVAVLAWIDRDRSPRL
TASGDPPTS"
gene complement(2433631..2434536)
/locus_tag="Rv2172c"
CDS complement(2433631..2434536)
/codon_start=1
/transl_table=11
/locus_tag="Rv2172c"
/product="Conserved protein"
/note="Rv2172c, (MTV021.05c), len: 301 aa. Conserved
protein, equivalent to Mycobacterium leprae conserved
hypothetical protein ML0901 (304 aa). FASTA scores: opt:
1656, E(): 7.7e-98; 81.271% identity in 299 aa overlap
(1-299:1-299) >emb|CAA18681.1| (AL022602)
>gi|13092971|emb|CAC31282.1| (AL583920). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2172c"
/db_xref="EnsemblGenomes-Tr:CCP44949"
/db_xref="UniProtKB/TrEMBL:O53506"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44949.1"
/translation="MTLNTIALELVPPNLEGGKERAIEDARKVVQYSAASGLDGRIRH
VMMPGMIAEDDDRPIPMQPKLDVLDFWSIIKPELAGVHGLCTQVTAFMDEPSLHRRLV
DLSDAGMEGIVFVGVPRTMQDGEGSGVAPTDALSLYRQLVANRGVIVIPTRDGEQGRL
NFKCSRGATYGMTQLLYSDAIVGFLREFARTTEHRPEILLSFGFVPKVETRIGLINWL
IQDPGNAAVADEQAFVQKLAGSEPARRRRLMVDLYKRVLDGVADLGFPLSIHLEATYG
VSAAAFETFAEMLAYWSPAEPGKPD"
gene 2434847..2435905
/gene="idsA2"
/locus_tag="Rv2173"
CDS 2434847..2435905
/codon_start=1
/transl_table=11
/gene="idsA2"
/locus_tag="Rv2173"
/product="Probable geranylgeranyl pyrophosphate synthetase
IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl
diphosphate synthase)"
/note="Rv2173, (MTV021.06), len: 352 aa. Probable
idsA2,geranylgeranyl pyrophosphate synthase, similar to
many e.g. Q54193 geranylgeranyl pyrophosphate synthase
from Streptomyces griseus (425 aa). Contains PS00723 and
PS00444Polyprenyl synthetases signature 1 and 2. FASTA
scores: sptr|Q54193|Q54193 geranylgeranyl pyrophosphate
synthase (425 aa) opt: 744, E(): 0; 39.2% identity in 352
aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2173"
/db_xref="EnsemblGenomes-Tr:CCP44950"
/db_xref="GOA:O53507"
/db_xref="InterPro:IPR000092"
/db_xref="InterPro:IPR008949"
/db_xref="InterPro:IPR033749"
/db_xref="UniProtKB/TrEMBL:O53507"
/inference="protein motif:PROSITE:PS00723"
/inference="protein motif:PROSITE:PS00444"
/protein_id="CCP44950.1"
/translation="MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKR
LRPLFAYWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLR
YAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWA
DIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVA
AIFEHFGADLGVAFQLRDDVLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSD
PLAAKLLRTSIGTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINA
TAKAGLSELAMMAANRSA"
gene 2435909..2437459
/gene="mptA"
/locus_tag="Rv2174"
CDS 2435909..2437459
/codon_start=1
/transl_table=11
/gene="mptA"
/locus_tag="Rv2174"
/product="Alpha(1->6)mannosyltransferase. Possible
conserved integral membrane protein."
/note="Rv2174, (MTV021.07), len: 516 aa. MptA
(mannopyranosyltransferase A) (See Mishra et al., 2007).
Possible conserved integral membrane protein, similar to
some hypothetical mycobacterial proteins e.g.
Mycobacterium leprae ML0899 probable integral-membrane
protein (505 aa) and MLCL536_26 (593 aa). FASTA scores:
ML0899 opt: 2715; 78.884% identity in 502 aa overlap and
gp|Z99125|MLCL536_26 Mycobacterium leprae cosmid L536.
(593 aa) opt: 552, E(): 7.1e-30; 31.6% identity in 513 aa
overlap. Also similar to Rv1459c. Predicted to be in the
GT-C superfamily of glycosyltransferases (See Liu and
Mushegian, 2003)."
/db_xref="EnsemblGenomes-Gn:Rv2174"
/db_xref="EnsemblGenomes-Tr:CCP44951"
/db_xref="GOA:O53508"
/db_xref="InterPro:IPR017822"
/db_xref="UniProtKB/Swiss-Prot:O53508"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44951.1"
/translation="MTTPSHAPAVDLATAKDAVVQHLSRLFEFTTGPQGGPARLGFAG
AVLITAGGLGAGSVRQHDPLLESIHMSWLRFGHGLVLSSILLWTGVGVMLLAWLGLGR
RVLAGEATEFTMRATTVIWLAPLLLSVPVFSRDTYSYLAQGALLRDGLDPYAVGPVGN
PNALLDDVSPIWTITTAPYGPAFILVAKFVTVIVGNNVVAGTMLLRLCMLPGLALLVW
ATPRLASHLGTHGPTALWICVLNPLVLIHLMGGVHNEMLMVGLMTAGIALTVQGRNVA
GIILITVAIAVKATAGIALPFLVWVWLRHLRERRGYRPVQAFLAAAAISLLIFVAVFA
VLSAVAGVGLGWLTALAGSVKIINWLTVPTGAANVIHALGRGLFTVDFYTLLRITRLI
GIVIIAVSLPLLWWRFRRDDRAALTGVAWSMLIVVLFVPAALPWYYSWPLAVAAPLAQ
ARRAIAAIAGLSTWVMVIFKPDGSHGMYSWLHFWIATACALTAWYVLYRSPDRRGVQA
ATPVVNTP"
gene complement(2437446..2437886)
/locus_tag="Rv2175c"
CDS complement(2437446..2437886)
/codon_start=1
/transl_table=11
/locus_tag="Rv2175c"
/product="Conserved regulatory protein"
/note="Rv2175c, (MTV021.08c), len: 146 aa. Conserved
protein, possibly involved in regulation. Contains
possible helix-turn-helix domain at aa 31-52 (Score 1042,
+2.74 SD). Equivalent to Mycobacterium leprae ML0898
putative DNA-binding protein (134 aa). FASTA scores: opt:
747; 82.090% identity in 134 aa overlap (AL022602)
>gi|13092969|emb|CAC31279.1| (AL583920). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2175c"
/db_xref="EnsemblGenomes-Tr:CCP44952"
/db_xref="GOA:O53509"
/db_xref="InterPro:IPR041098"
/db_xref="PDB:2KFS"
/db_xref="UniProtKB/Swiss-Prot:O53509"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44952.1"
/translation="MPGRAPGSTLARVGSIPAGDDVLDPDEPTYDLPRVAELLGVPVS
KVAQQLREGHLVAVRRAGGVVIPQVFFTNSGQVVKSLPGLLTILHDGGYRDTEIMRWL
FTPDPSLTITRDGSRDAVSNARPVDALHAHQAREVVRRAQAMAY"
gene complement(2437823..2437866)
/gene="mcr5"
ncRNA complement(2437823..2437866)
/gene="mcr5"
/product="Fragment of putative small regulatory RNA"
/note="mcr5, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), cloned from M. bovis BCG
Pasteur; ends not mapped, ~82 nt band detected by Northern
blot."
/ncRNA_class="other"
gene 2437941..2439140
/gene="pknL"
/locus_tag="Rv2176"
CDS 2437941..2439140
/codon_start=1
/transl_table=11
/gene="pknL"
/locus_tag="Rv2176"
/product="Probable transmembrane serine/threonine-protein
kinase L PknL (protein kinase L) (STPK L)"
/note="Rv2176, (MTV021.09), len: 399 aa. Probable
pknL,transmembrane serine/threonine-protein kinase (see
citation below), similar to many e.g. MLCB1770_9 (622 aa).
Lacks C-terminal domain and ends with putative
transmembrane segment. Contains PS00108 Serine/Threonine
protein kinases active-site signature. FASTA scores:
Z70722|MLC B1770_9 Mycobacterium leprae cosmid B1770 (622
aa) opt: 732, E(): 5.9e-23; 44.4% identity in 266 aa
overlap. Also similar to several Mycobacterium
tuberculosis STPK proteins e.g. Rv0014c|PKNB,
Rv0015c|PKNA, Rv1743|PKNE, Rv1266c|PKNH etc. Contains
Hank's kinase subdomain. Belongs to the Ser/Thr family of
protein kinases."
/db_xref="EnsemblGenomes-Gn:Rv2176"
/db_xref="EnsemblGenomes-Tr:CCP44953"
/db_xref="GOA:P9WI63"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="UniProtKB/Swiss-Prot:P9WI63"
/inference="protein motif:PROSITE:PS00108"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44953.1"
/translation="MVEAGTRDPLESALLDSRYLVQAKIASGGTSTVYRGLDVRLDRP
VALKVMDSRYAGDEQFLTRFRLEARAVARLNNRALVAVYDQGKDGRHPFLVMELIEGG
TLRELLIERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKLAD
FGLVRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPF
TGDSALSIAYQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLE
AIAEELALPEFRVPAPRNSAQHRSAALYRSRITQQGQLGAKPVHHPTRQLTRQPGDCS
EPASGSEPEHEPITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIG
SNLSGLL"
mobile_element complement(2439145..2439948)
/mobile_element_type="insertion sequence:IS1558-1"
/note="IS1558-1, len: 804 nt. Insertion sequence
IS1558,nearly identical to complement of region 24105
24908 in EM_BA:MTCY428 Z81451 Mycobacterium tuberculosis
cosmid Y428."
gene complement(2439282..2439947)
/locus_tag="Rv2177c"
CDS complement(2439282..2439947)
/codon_start=1
/transl_table=11
/locus_tag="Rv2177c"
/product="Possible transposase"
/note="Rv2177c, (MTV021.10c), len: 221 aa. Possible IS1558
transposase (see citation below), similar to several is
element proteins and transposases but nearly identical to
last 221 residues of MTCY428_23 (333 aa). FASTA scores:
Z81451|MTCY428_23 Mycobacterium tuberculosis cosmid (333
aa) opt: 1491, E() : 0; 98.6% identity in 221 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2177c"
/db_xref="EnsemblGenomes-Tr:CCP44954"
/db_xref="GOA:O53511"
/db_xref="InterPro:IPR003346"
/db_xref="UniProtKB/TrEMBL:O53511"
/protein_id="CCP44954.1"
/translation="MRSKIPDLQRALEGRFDDHHALMCRLHLAHLDQLDAMIGALDEQ
IEQLMHPFCARRELIASIPGIGVGASATVISEIGADPAAWFPSAEHLASWVRLCPGNH
ESAGKRHHGARRTGNQHLQPVLVECAWAAVRTDGYLREYYRRQVRKFGGFRSPAANKK
AIIAVAHKLIVIIWHVLATGRPYQDLGADYFTTRMDPDKERRRLVAKLEAQGLGVTLE
PAA"
gene complement(2440332..2441720)
/gene="aroG"
/locus_tag="Rv2178c"
CDS complement(2440332..2441720)
/codon_start=1
/transl_table=11
/gene="aroG"
/locus_tag="Rv2178c"
/product="3-deoxy-D-arabino-heptulosonate 7-phosphate
synthase AroG (DAHP synthetase,
phenylalanine-repressible)"
/note="Rv2178c, (MTV021.11c), len: 462 aa.
aroG,3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
similar to many, especially those from plants. FASTA
scores: Y15113|M C3DDAH7P_1Morinda citrifolia mRNA for
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (535
aa) opt: 1421, E(): 0; 48.3% identity in 443 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2178c"
/db_xref="EnsemblGenomes-Tr:CCP44955"
/db_xref="GOA:O53512"
/db_xref="InterPro:IPR002480"
/db_xref="InterPro:IPR013785"
/db_xref="PDB:2B7O"
/db_xref="PDB:2W19"
/db_xref="PDB:2W1A"
/db_xref="PDB:2YPO"
/db_xref="PDB:2YPP"
/db_xref="PDB:2YPQ"
/db_xref="PDB:3KGF"
/db_xref="PDB:3NUD"
/db_xref="PDB:3NUE"
/db_xref="PDB:3NV8"
/db_xref="PDB:3PFP"
/db_xref="PDB:3RZI"
/db_xref="PDB:5CKV"
/db_xref="PDB:5CKX"
/db_xref="PDB:5E2L"
/db_xref="PDB:5E40"
/db_xref="PDB:5E4N"
/db_xref="PDB:5E5G"
/db_xref="PDB:5E7Z"
/db_xref="PDB:5EX4"
/db_xref="UniProtKB/Swiss-Prot:O53512"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44955.1"
/translation="MNWTVDIPIDQLPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQ
ALAMRTVLESVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGN
VRALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAPDAA
AREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRTSPAGARYEALA
TEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYERAMLRLSDGDDGEPQLFDLSA
HTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPELAVEYVERLDPHNKPGRLTL
VSRMGNHKVRDLLPPIVEKVQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQ
GFFEVHRALGTHPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSL
ELAFLVAEMLRD"
gene complement(2441811..2442317)
/locus_tag="Rv2179c"
CDS complement(2441811..2442317)
/codon_start=1
/transl_table=11
/locus_tag="Rv2179c"
/product="Conserved hypothetical protein"
/note="Rv2179c, (MTV021.12c), len: 168 aa. Conserved
hypothetical protein, equivalent to conserved hypothetical
protein from Mycobacterium leprae ML0895 conserved
hypothetical protein (171 aa). FASTA scores: opt: 977,
E(): 1.4e-58; 82.530% identity in 166 aa overlap
(AL022602). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2179c"
/db_xref="EnsemblGenomes-Tr:CCP44956"
/db_xref="GOA:P9WJ73"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR030853"
/db_xref="InterPro:IPR033390"
/db_xref="InterPro:IPR036397"
/db_xref="PDB:4HEC"
/db_xref="PDB:4HVJ"
/db_xref="UniProtKB/Swiss-Prot:P9WJ73"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44956.1"
/translation="MRYFYDTEFIEDGHTIELISIGVVAEDGREYYAVSTEFDPERAG
SWVRTHVLPKLPPPASQLWRSRQQIRLDLEEFLRIDGTDSIELWAWVGAYDHVALCQL
WGPMTALPPTVPRFTRELRQLWEDRGCPRMPPRPRDVHDALVDARDQLRRFRLITSTD
DAGRGAAR"
gene complement(2442327..2443214)
/locus_tag="Rv2180c"
CDS complement(2442327..2443214)
/codon_start=1
/transl_table=11
/locus_tag="Rv2180c"
/product="Probable conserved integral membrane protein"
/note="Rv2180c, (MTV021.13c), len: 295 aa. Probable
conserved integral membrane protein, similar to
pir||T35292 probable integral membrane protein from
Streptomyces coelicolor >gi|5578858|emb|CAB51260.1|
(AL096872) (246 aa) (36% identity in 249 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2180c"
/db_xref="EnsemblGenomes-Tr:CCP44957"
/db_xref="GOA:O53514"
/db_xref="UniProtKB/TrEMBL:O53514"
/protein_id="CCP44957.1"
/translation="MEVFHWLQHDIVDRGRLPLLCCLVAFVLTFLVTRSFVRFIHRRA
ADGRPARWWQPRNVHIGSVHIHHVAFGVVLVMISGLTLVTLSVDGREPEFTIAASIFG
VGAALVLDEYALILHLSDVYWEEDGRTSVDAVFAAVAVAGLLIMGLHPLIFFLPVRQG
ANWVVLQTTLIAGLVLTLPLAVVVLLKGKVWTGLLGMFVVVLLVVGAVRLSRPHAPWA
RWRYTRHPEKMRRALQRERTWRRPVVRIKLWLQYVIAGTPRMPDERAVDAQLDQDVRP
APPPERTAPILISGSVWSD"
gene 2443302..2444585
/locus_tag="Rv2181"
CDS 2443302..2444585
/codon_start=1
/transl_table=11
/locus_tag="Rv2181"
/product="Alpha(1->2)mannosyltransferase"
/note="Rv2181, (MTV021.14), len: 427 aa.
Alpha(1->2)mannosyltransferase (See Kaur et al., 2006).
Probable integral membrane protein, similar to others in
Mycobacterium tuberculosis e.g. Rv1159 (MTCI65.26, 431
aa). Start uncertain. FASTA scores: Z95584|MTCI65_26 (431
aa) opt: 428, E(): 8e-22; 31.2% identity in 407 aa
overlap. Predicted to be in the GT-C superfamily of
glycosyltransferases (See Liu and Mushegian, 2003)."
/db_xref="EnsemblGenomes-Gn:Rv2181"
/db_xref="EnsemblGenomes-Tr:CCP44958"
/db_xref="GOA:P9WMZ9"
/db_xref="InterPro:IPR018584"
/db_xref="UniProtKB/Swiss-Prot:P9WMZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44958.1"
/translation="MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYR
IDIDIYQMGARAWLDGRPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAAS
VAITVLTLVLLIASTAIVLTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPIS
SNFAFGQINVVLMTLVIVDCFPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRA
ALTALASFAVATLLGFVLAWRDSWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIG
DDERFALWVAGSLLVLAATIWAMRRVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWM
LPAVLVIGLLGWRRRNVALAMLSLAGVVLMRWTPIDLLPQHRETTAVWWRQLAGMSYV
WWALAVIVVAGLTVTARMTPQRSLTRGLTPAPTAS"
gene complement(2444586..2445329)
/locus_tag="Rv2182c"
CDS complement(2444586..2445329)
/codon_start=1
/transl_table=11
/locus_tag="Rv2182c"
/product="1-acylglycerol-3-phosphate O-acyltransferase"
/note="Rv2182c, (MTV021.15c), len: 247 aa. Probable
1-acylglycerol-3-phosphate O-acyltransferase, similar to
many e.g. in Streptomyces. Contains PS00017
ATP/GTP-binding site motif A (P-loop). FASTA scores:
pir||T35503 1-acylglycerol-3-phosphate O-acyltransferase
homolog SC6E10.16c - Streptomyces coelicolor
>gi|5689932|emb|CAB51970.1| (AL109661) hypothetical
protein [Streptomyces coelicolor A3(2)] Length = 262,
Expect = 6e-61 (54% identity in 215 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2182c"
/db_xref="EnsemblGenomes-Tr:CCP44959"
/db_xref="GOA:O53516"
/db_xref="InterPro:IPR002123"
/db_xref="UniProtKB/TrEMBL:O53516"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44959.1"
/translation="MWYYLFKYIFMGPLFTLLGRPKVEGLEYIPSSGPAILASNHLAV
ADSFYLPLVVRRRIWFLAKSEYFTGTGLKGWINRWFYSVSGQVPIDRTNADSAQGALQ
TAVVLLGQGKLLGMYPEGTRSPDGRLYKGKTGLARLALHTGVPVIPVAMIGTNVVNPP
GRKMLRFGRVTVRFGKPMDFSRFEGLAGNHFIERAVTDEVIYELMGLSGQEYVDIYAA
SVKDGRNAGGAGANPNSTDAARIPETAAG"
gene complement(2445415..2445810)
/locus_tag="Rv2183c"
CDS complement(2445415..2445810)
/codon_start=1
/transl_table=11
/locus_tag="Rv2183c"
/product="Conserved protein"
/note="Rv2183c, (MTV021.16c), len: 131 aa. Conserved
protein, equivalent to Mycobacterium leprae hypothetical
protein ML0891 (MLCB268.25c, 130 aa). FASTA scores: opt:
558, E(): 8.3e-28; 61.832% identity in 131 aa overlap
>gi|13092963|emb|CAC31272.1| (AL583920) (AL022602). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2183c"
/db_xref="EnsemblGenomes-Tr:CCP44960"
/db_xref="UniProtKB/TrEMBL:O53517"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44960.1"
/translation="MSGAHTDVRPELRKLAQAILDGIDPAVRVAAAMASGGGPGTGKC
QQVWCPLCALAALVTGEQHPLLTVIADHSLALLEVIRAIVDDIDRSAKPPPEGPPGGG
QTGASGGENTNGEGSMKSHYQAIPVTIEE"
gene complement(2445807..2446946)
/locus_tag="Rv2184c"
CDS complement(2445807..2446946)
/codon_start=1
/transl_table=11
/locus_tag="Rv2184c"
/product="Conserved hypothetical protein"
/note="Rv2184c, (MTV021.17c), len: 379 aa. Conserved
hypothetical protein, equivalent to hypothetical protein
ML0890 (415 aa) from Mycobacterium leprae and also shows
some similarity to other hypothetical proteins. FASTA
scores: ML0890 opt: 1949; 79.630% identity in 378 aa
overlap >emb|CAA18692.1| (AL022602)
>gi|13092962|emb|CAC31271.1| (AL583920) and
sptr|Q55794|Q55794 hypothetical 44.6 kDa protein. (396 aa)
opt: 251, E(): 3.3e-09; 25.5% identity in 384 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2184c"
/db_xref="EnsemblGenomes-Tr:CCP44961"
/db_xref="GOA:O53518"
/db_xref="InterPro:IPR008978"
/db_xref="InterPro:IPR016300"
/db_xref="InterPro:IPR025723"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR040612"
/db_xref="UniProtKB/TrEMBL:O53518"
/protein_id="CCP44961.1"
/translation="MVVSTDQAHSLGDVLGIAVPPTGQGDPVRVLAYDPEAGGGFLDA
LALDTLALLEGRWLHVVETLDRRFPGSELSSIAPEELCALPGIQEVLGLHAVGELAAA
RRWDRIVVDCASTADALRMLTLPATFGLYVERAWPRHRRLSIGADDGRSAVLAELLER
IRASVERLSTLLTDGALVSAHLVLTPERVVAAEAVRTLGSLALMGVRVEELLVNQLLV
QDENYEYRSLPDHPAFHWYAERIGEQRAVLDDLDATIGDVALVLVPHLAGEPIGPKAL
GGLLDSARRRQGSAPPGPLQPIVDLESGSGLASIYRLRLALPQLDPGTLTLGRADDDL
IVSAGGMRRRVRLASVLRRCTVLDAHLRGGELTVRFRPNPEVWPT"
gene complement(2447066..2447500)
/gene="TB16.3"
/locus_tag="Rv2185c"
CDS complement(2447066..2447500)
/codon_start=1
/transl_table=11
/gene="TB16.3"
/locus_tag="Rv2185c"
/product="Conserved protein TB16.3"
/note="Rv2185c, (MTV021.18c), len: 144 aa.
TB16.3,conserved protein, similar to other hypothetical
actinomycete proteins and equivalent to Mycobacterium
leprae ML0889 (144 aa). Some similarity to Mycobacterium
tuberculosis Rv0854, Rv0856, Rv0857, Rv0164 and other
Mycobacterium leprae proteins. FASTA scores : ML0889 opt:
811; 85.417% identity in 144 aa overlap (AL022602). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2185c"
/db_xref="EnsemblGenomes-Tr:CCP44962"
/db_xref="GOA:O53519"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:O53519"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44962.1"
/translation="MADKTTQTIYIDADPGEVMKAIADIEAYPQWISEYKEVEILEAD
DEGYPKRARMLMDAAIFKDTLIMSYEWPEDRQSLSWTLESSSLLKSLEGTYRLAPKGS
GTEVTYELAVDLAVPMIGMLKRKAERRLIDGALKDLKKRVEG"
gene complement(2447605..2447994)
/locus_tag="Rv2186c"
CDS complement(2447605..2447994)
/codon_start=1
/transl_table=11
/locus_tag="Rv2186c"
/product="Conserved hypothetical protein"
/note="Rv2186c, (MTV021.19c), len: 129 aa. Conserved
hypothetical protein, equivalent to hypothetical
Mycobacterium leprae protein ML0888 (135 aa). FASTA
scores: ML0888 opt: 704, E(): 2.9e-43; 80.000% identity in
130 aa overlap CAA18694.1| (AL022602). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv2186c"
/db_xref="EnsemblGenomes-Tr:CCP44963"
/db_xref="UniProtKB/TrEMBL:O53520"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44963.1"
/translation="MNSIQIADETYVAADAARVSAAVADRCSWRRWWPDLRLQVTEDR
ADKGIRWTVTGALTGTMEIWLEPSMDGVLLHYFLHAEPTGVAAWQLARMNLARMTHHR
RVAGKKMAFEVKTVLERSRPIGVSPVT"
gene 2448160..2449962
/gene="fadD15"
/locus_tag="Rv2187"
CDS 2448160..2449962
/codon_start=1
/transl_table=11
/gene="fadD15"
/locus_tag="Rv2187"
/product="Long-chain-fatty-acid-CoA ligase FadD15
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv2187, (MTV021.20), len: 600 aa.
fadD15,long-chain-fatty-acid-CoA ligase, similar to
several e.g. P44446|LCFH_HAEIN putative
long-chain-fatty-acid--CoA ligase from Haemophilus
influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E():
0, (31.5% identity in 578 aa overlap); etc. Contains
PS00455 Putative AMP-binding domain signature. Belongs to
the ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv2187"
/db_xref="EnsemblGenomes-Tr:CCP44964"
/db_xref="GOA:O53521"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:O53521"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44964.1"
/translation="MREISVPAPFTVGEHDNVAAMVFEHERDDPDYVIYQRLIDGVWT
DVTCAEAANQIRAAALGLISLGVQAGDRVVIFSATRYEWAILDFAILAVGAVTVPTYE
TSSAEQVRWVLQDSEAVVLFAETDSHATMVAELSGSVPALREVLQIAGSGPNALDRLT
EAGASVDPAELTARLAALRSTDPATLIYTSGTTGRPKGCQLTQSNLVHEIKGARAYHP
TLLRKGERLLVFLPLAHVLARAISMAAFHSKVTVGFTSDIKNLLPMLAVFKPTVVVSV
PRVFEKVYNTAEQNAANAGKGRIFAIAAQTAVDWSEACDRGGPGLLLRAKHAVFDRLV
YRKLRAALGGNCRAAVSGGAPLGARLGHFYRGAGLTIYEGYGLSGTSGGVAISQFNDL
KIGTVGKPVPGNSLRIADDGELLVRGGVVFSGYWRNEQATTEAFTDGWFKTGDLGAVD
EDGFLTITGRKKEIIVTAGGKNVAPAVLEDQLRAHPLISQAVVVGDAKPFIGALITID
PEAFEGWKQRNSKTAGASVGDLATDPDLIAEIDAAVKQANLAVSHAESIRKFRILPVD
FTEDTGELTPTMKVKRKVVAEKFASDIEAIYNKE"
gene complement(2449993..2451150)
/gene="pimB"
/locus_tag="Rv2188c"
CDS complement(2449993..2451150)
/codon_start=1
/transl_table=11
/gene="pimB"
/locus_tag="Rv2188c"
/product="Mannosyltransferase PimB"
/note="Rv2188c, (MTV021.21c), len: 385 aa. PimB
(previously known as pimB'), mannosyltransferase.
Equivalent to Mycobacterium leprae ML0886 putative
glycosyl transferase (384 aa). FASTA scores: ML0886
(CAA18697.1| (AL022602) ) opt: 2113, E(): 1.8e-106;
81.462% identity in 383 aa overlap; sptr|P73369|P73369
hypothetical 46.2 kDa protein (404 aa) opt: 379, E():
2.2e-18; 27.5% identity in 397 aa overlap. Start changed
since first submission, now 14 aa shorter."
/db_xref="EnsemblGenomes-Gn:Rv2188c"
/db_xref="EnsemblGenomes-Tr:CCP44965"
/db_xref="GOA:P9WMZ3"
/db_xref="InterPro:IPR001296"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/Swiss-Prot:P9WMZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44965.1"
/translation="MSRVLLVTNDFPPRRGGIQSYLGEFVGRLVGSRAHAMTVYAPQW
KGADAFDDAARAAGYRVVRHPSTVMLPGPTVDVRMRRLIAEHDIETVWFGAAAPLALL
APRARLAGASRVLASTHGHEVGWSMLPVARSVLRRIGDGTDVVTFVSSYTRSRFASAF
GPAASLEYLPPGVDTDRFRPDPAARAELRKRYRLGERPTVVCLSRLVPRKGQDTLVTA
LPSIRRRVDGAALVIVGGGPYLETLRKLAHDCGVADHVTFTGGVATDELPAHHALADV
FAMPCRTRGAGMDVEGLGIVFLEASAAGVPVIAGNSGGAPETVQHNKTGLVVDGRSVD
RVADAVAELLIDRDRAVAMGAAGREWVTAQWRWDTLAAKLADFLRGDDAAR"
gene complement(2451247..2452020)
/locus_tag="Rv2189c"
CDS complement(2451247..2452020)
/codon_start=1
/transl_table=11
/locus_tag="Rv2189c"
/product="Conserved hypothetical protein"
/note="Rv2189c, (MTV021.22c), len: 257 aa. Conserved
hypothetical protein; some similarity to hypothetical
protein SC6G10.07c (385 aa) from Streptomyces coelicolor
A3(2). Smith-Waterman scores: pir||T35516 hypothetical
protein SC6G10.07c - Streptomyces coelicolor
>gi|4539203|emb|CAB39861.1| (AL049497) Expect = 2e-08; 30%
identity in 245 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2189c"
/db_xref="EnsemblGenomes-Tr:CCP44966"
/db_xref="UniProtKB/TrEMBL:O53523"
/protein_id="CCP44966.1"
/translation="MRDGPAAPAQVVAPADGFVALRVADDRTVRLLSLGGAATDRLLS
RIAAGIDAAVDEVVAFWGTDWSHDIFVVAAGSDEQFHAAAGGGLASQWADIAAITVVD
RVDPARRTVVGQRIVFAPGAAHMSPAALRIVLGHELFHYAARADTALDAPRWLAEGVA
DFVARPKTPPPADAVSVALSLPSDTDLDTPGPQRSLAYDRAWWFARFVAAAYGTAKLR
ELYLATCGVGHFDLATAAHDVLGIDAAGLLARWQRWLMG"
gene complement(2452115..2453272)
/locus_tag="Rv2190c"
CDS complement(2452115..2453272)
/codon_start=1
/transl_table=11
/locus_tag="Rv2190c"
/product="Conserved hypothetical protein"
/note="Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa.
Conserved hypothetical protein; similar to other
hypothetical mycobacterial proteins, including
Rv1477,Rv1478, Rv1566c, Rv0024, that are similar to
protein p60 precursors from Listeria e.g. Q018
38|P60_LISSE protein p60 precursor (invasion-associated
protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25
(281 aa) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa
overlap and sp|Q01838|P60_LISSE protein P60 precursor (523
aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa
overlap."
/db_xref="EnsemblGenomes-Gn:Rv2190c"
/db_xref="EnsemblGenomes-Tr:CCP44967"
/db_xref="GOA:P9WHU3"
/db_xref="InterPro:IPR000064"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/Swiss-Prot:P9WHU3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44967.1"
/translation="MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDAL
AKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTA
VNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAV
KAEQAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALAD
PGPVPAVAAIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAV
VQAALTQVGAPYAWGGAAPGGFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDL
QPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY"
gene 2453819..2455756
/locus_tag="Rv2191"
CDS 2453819..2455756
/codon_start=1
/transl_table=11
/locus_tag="Rv2191"
/product="Conserved hypothetical protein"
/note="Rv2191, (MTCY190.02), len: 645 aa. Conserved
hypothetical protein, similar to SW:DP3A_B ACSU P13267 DNA
polymerase III, alpha chain (31.3% identity in 249 aa
overlap) and SW:UVRC_ECOLI P07028 excinuclease ABC subunit
C (25.7% identity in 230 aa overlap). Also similar to M.
tuberculosis Rv3711c (dnaQ DNA polymerase III e chain) and
Rv1420 (uvrC excinuclease ABC subunit C)"
/db_xref="EnsemblGenomes-Gn:Rv2191"
/db_xref="EnsemblGenomes-Tr:CCP44968"
/db_xref="GOA:P9WLJ1"
/db_xref="InterPro:IPR000305"
/db_xref="InterPro:IPR006054"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR013520"
/db_xref="InterPro:IPR035901"
/db_xref="InterPro:IPR036397"
/db_xref="UniProtKB/Swiss-Prot:P9WLJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44968.1"
/translation="MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFV
VVDLETTGGRTTGNDATPPDAITEIGAVKVCGGAVLGEFATLVNPQHSIPPQIVRLTG
ITTAMVGNAPTIDAVLPMFFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLC
TMRLARRVLSRDEAPSVRLAALARLFAVASNPTHRALDDARATVDVLHALIERVGNQG
VHTYAELRSYLPNVTQAQRCKRVLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVS
QYFNGTDRRKRMTEMVMLASSIDHVECAHPLEAGVRELRMLSTHAPPYNRRSKFPYRW
WWVALTDEAFPRLSVIRAPRHDRVVGPFRSRSKAAETAALLARCTGLRTCTTRLTRSA
RHGPACPELEVSACPAARDVTAAQYAEAVLRAAALIGGLDNAALAAAVQQVTELAERR
RYESAARLRDHLATAIEALWHGQRLRALAALPELIAAKPDGPREGGYQLAVIRHGQLA
AAGRAPRGVPPMPVVDAIRRGAQAILPTPAPLGGALVEEIALIARWLAEPGVRIVGVS
NDAAGLASPVRSAGPWAAWAATARSAQLAGEQLSRGWQSDLPTEPHPSREQLFGRTGV
DCRTGPPQPLLPGRQPFSTAG"
gene complement(2455631..2456743)
/gene="trpD"
/locus_tag="Rv2192c"
CDS complement(2455631..2456743)
/codon_start=1
/transl_table=11
/gene="trpD"
/locus_tag="Rv2192c"
/product="Probable anthranilate phosphoribosyltransferase
TrpD"
/note="Rv2192c, (MTCY190.03c), len: 370 aa. Probable
trpD,anthranilate phosphoribosyltransferase (see citation
below), similar to e.g. TRPD_LACCA|P17170, (43.2% identity
in 308 aa overlap). Initiation codon uncertain, gtg at
4086 in MTCY190 favoured by homology but this has no clear
ribosome binding site."
/db_xref="EnsemblGenomes-Gn:Rv2192c"
/db_xref="EnsemblGenomes-Tr:CCP44969"
/db_xref="GOA:P9WFX5"
/db_xref="InterPro:IPR000312"
/db_xref="InterPro:IPR005940"
/db_xref="InterPro:IPR017459"
/db_xref="InterPro:IPR035902"
/db_xref="InterPro:IPR036320"
/db_xref="PDB:1ZVW"
/db_xref="PDB:2BPQ"
/db_xref="PDB:3QQS"
/db_xref="PDB:3QR9"
/db_xref="PDB:3QS8"
/db_xref="PDB:3QSA"
/db_xref="PDB:3R6C"
/db_xref="PDB:3R88"
/db_xref="PDB:3TWP"
/db_xref="PDB:3UU1"
/db_xref="PDB:4GIU"
/db_xref="PDB:4GKM"
/db_xref="PDB:4IJ1"
/db_xref="PDB:4M0R"
/db_xref="PDB:4N5V"
/db_xref="PDB:4N8Q"
/db_xref="PDB:4N93"
/db_xref="PDB:4OWM"
/db_xref="PDB:4OWN"
/db_xref="PDB:4OWO"
/db_xref="PDB:4OWQ"
/db_xref="PDB:4OWS"
/db_xref="PDB:4OWU"
/db_xref="PDB:4OWV"
/db_xref="PDB:4X58"
/db_xref="PDB:4X59"
/db_xref="PDB:4X5A"
/db_xref="PDB:4X5B"
/db_xref="PDB:4X5C"
/db_xref="PDB:4X5D"
/db_xref="PDB:4X5E"
/db_xref="PDB:5BNE"
/db_xref="PDB:5BYT"
/db_xref="PDB:5C1R"
/db_xref="PDB:5C2L"
/db_xref="PDB:5C7S"
/db_xref="UniProtKB/Swiss-Prot:P9WFX5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44969.1"
/translation="MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQ
AAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDA
VDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDL
GPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGL
IGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDP
AGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRA
EWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI"
gene 2456901..2457512
/gene="ctaE"
/locus_tag="Rv2193"
CDS 2456901..2457512
/codon_start=1
/transl_table=11
/gene="ctaE"
/locus_tag="Rv2193"
/product="Probable cytochrome C oxidase (subunit III)
CtaE"
/note="Rv2193, (MTCY190.04), len: 203 aa. Probable
ctaE,cytochrome c oxidase polypeptide III (cox3), with
strong similarity to others e.g. COX3_SYNY3|Q06475 (29.8%
identity in 225 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2193"
/db_xref="EnsemblGenomes-Tr:CCP44970"
/db_xref="GOA:P9WP67"
/db_xref="InterPro:IPR000298"
/db_xref="InterPro:IPR013833"
/db_xref="InterPro:IPR024791"
/db_xref="InterPro:IPR035973"
/db_xref="UniProtKB/Swiss-Prot:P9WP67"
/protein_id="CCP44970.1"
/translation="MTSAVGTSGTAITSRVHSLNRPNMVSVGTIVWLSSELMFFAGLF
AFYFSARAQAGGNWPPPPTELNLYQAVPVTLVLIASSFTCQMGVFAAERGDIFGLRRW
YVITFLMGLFFVLGQAYEYRNLMSHGTSIPSSAYGSVFYLATGFHGLHVTGGLIAFIF
LLVRTGMSKFTPAQATASIVVSYYWHFVDIVWIALFTVIYFIR"
gene 2457553..2458395
/gene="qcrC"
/locus_tag="Rv2194"
CDS 2457553..2458395
/codon_start=1
/transl_table=11
/gene="qcrC"
/locus_tag="Rv2194"
/product="Probable ubiquinol-cytochrome C reductase QcrC
(cytochrome C subunit)"
/note="Rv2194, (MTCY190.05), len: 280 aa. Probable
qcrC,Ubiquinol-cytochrome C reductase cytochrome C subunit
(cyoA), shows similarity to cytochrome c family; contains
2 X PS00190 Cytochrome c family heme-binding site
signature."
/db_xref="EnsemblGenomes-Gn:Rv2194"
/db_xref="EnsemblGenomes-Tr:CCP44971"
/db_xref="GOA:P9WP35"
/db_xref="InterPro:IPR009056"
/db_xref="InterPro:IPR009152"
/db_xref="InterPro:IPR036909"
/db_xref="UniProtKB/Swiss-Prot:P9WP35"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44971.1"
/translation="MTKLGFTRSGGSKSGRTRRRLRRRLSGGVLLLIALTIAGGLAAV
LTPTPQVAVADESSSALLRTGKQLFDTSCVSCHGANLQGVPDHGPSLIGVGEAAVYFQ
VSTGRMPAMRGEAQAPRKDPIFDEAQIDAIGAYVQANGGGPTVVRNPDGSIATQSLRG
NDLGRGGDLFRLNCASCHNFTGKGGALSSGKYAPDLAPANEQQILTAMLTGPQNMPKF
SNRQLSFEAKKDIIAYVKVATEARQPGGYLLGGFGPAPEGMAMWIIGMVAAIGLALWI
GARS"
gene 2458392..2459681
/gene="qcrA"
/locus_tag="Rv2195"
CDS 2458392..2459681
/codon_start=1
/transl_table=11
/gene="qcrA"
/locus_tag="Rv2195"
/product="Probable rieske iron-sulfur protein QcrA"
/note="Rv2195, (MTCY190.06), len: 429 aa. Probable
qcrA,Ubiquinol-cytochrome C reductase iron-sulfur subunit
(cyoB), shows some similarity to cytochrome B6-F complex
iron-sulphur subunits (Rieske iron-sulfur protein);
contains PS00200 Rieske iron-sulfur protein signature 2"
/db_xref="EnsemblGenomes-Gn:Rv2195"
/db_xref="EnsemblGenomes-Tr:CCP44972"
/db_xref="GOA:P9WH23"
/db_xref="InterPro:IPR014349"
/db_xref="InterPro:IPR017941"
/db_xref="InterPro:IPR036922"
/db_xref="UniProtKB/Swiss-Prot:P9WH23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44972.1"
/translation="MSRADDDAVGVPPTCGGRSDEEERRIVPGPNPQDGAKDGAKATA
VPREPDEAALAAMSNQELLALGGKLDGVRIAYKEPRWPVEGTKAEKRAERSVAVWLLL
GGVFGLALLLIFLFWPWEFKAADGESDFIYSLTTPLYGLTFGLSILSIAIGAVLYQKR
FIPEEISIQERHDGASREIDRKTVVANLTDAFEGSTIRRRKLIGLSFGVGMGAFGLGT
LVAFAGGLIKNPWKPVVPTAEGKKAVLWTSGWTPRYQGETIYLARATGTEDGPPFIKM
RPEDMDAGGMETVFPWRESDGDGTTVESHHKLQEIAMGIRNPVMLIRIKPSDLGRVVK
RKGQESFNFGEFFAFTKVCSHLGCPSSLYEQQSYRILCPCHQSQFDALHFAKPIFGPA
ARALAQLPITIDTDGYLVANGDFVEPVGPAFWERTTT"
repeat_region 2458392..2458449
/gene="qcrA"
/locus_tag="Rv2195"
/note="58 bp Mycobacterial Interspersed Repetitive
Unit,Class II I. Overlaps Rv2195 suggesting alternative
GTG start at 2458 468 may be used"
gene 2459678..2461327
/gene="qcrB"
/locus_tag="Rv2196"
CDS 2459678..2461327
/codon_start=1
/transl_table=11
/gene="qcrB"
/locus_tag="Rv2196"
/product="Probable ubiquinol-cytochrome C reductase QcrB
(cytochrome B subunit)"
/note="Rv2196, (MTCY190.07), len: 549 aa. Probable
qcrB,Ubiquinol-cytochrome C reductase cytochrome B subunit
(cytB), integral membrane protein, low similarity in
amino-terminal half to cytochrome b subunits, highly
similar at C-terminus to SW:12KD_MYCLE P15878 12 KD
protein PIR:S08427 (86.9% identity in 153 aa overlap).
FASTA scores: sp|Q45658|QCRB_BACST menaquinol-cytochrome C
reductase (224 aa) opt: 341, E(): 6.8e-15; 28.0% identity
in 207 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2196"
/db_xref="EnsemblGenomes-Tr:CCP44973"
/db_xref="GOA:P9WP37"
/db_xref="InterPro:IPR005797"
/db_xref="InterPro:IPR016174"
/db_xref="InterPro:IPR027387"
/db_xref="UniProtKB/Swiss-Prot:P9WP37"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44973.1"
/translation="MSPKLSPPNIGEVLARQAEDIDTRYHPSAALRRQLNKVFPTHWS
FLLGEIALYSFVVLLITGVYLTLFFDPSMVDVTYNGVYQPLRGVEMSRAYQSALDISF
EVRGGLFVRQIHHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEG
YFGYSLPDDLLSGLGLRAALSSITLGMPVIGTWLHWALFGGDFPGTILIPRLYALHIL
LLPGIILALIGLHLALVWFQKHTQFPGPGRTEHNVVGVRVMPVFAFKSGAFFAAIVGV
LGLMGGLLQINPIWNLGPYKPSQVSAGSQPDFYMMWTEGLARIWPPWEFYFWHHTIPA
PVWVAVIMGLVFVLLPAYPFLEKRFTGDYAHHNLLQRPRDVPVRTAIGAMAIAFYMVL
TLAAMNDIIALKFHISLNATTWIGRIGMVILPPFVYFITYRWCIGLQRSDRSVLEHGV
ETGIIKRLPHGAYIELHQPLGPVDEHGHPIPLQYQGAPLPKRMNKLGSAGSPGSGSFL
FADSAAEDAALREAGHAAEQRALAALREHQDSIMGSPDGEH"
gene complement(2461504..2462148)
/locus_tag="Rv2197c"
CDS complement(2461504..2462148)
/codon_start=1
/transl_table=11
/locus_tag="Rv2197c"
/product="Probable conserved transmembrane protein"
/note="Rv2197c, (MTCY190.08c), len: 214 aa. Probable
conserved transmembrane protein, equivalent to ML0878
conserved hypothetical protein (212 aa) of Mycobacterium
leprae. FASTA scores: opt: 858; 62.559% identity in 211 aa
overlap CAC31259.1|(AL583920). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv2197c"
/db_xref="EnsemblGenomes-Tr:CCP44974"
/db_xref="GOA:P9WLI9"
/db_xref="InterPro:IPR024381"
/db_xref="UniProtKB/Swiss-Prot:P9WLI9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44974.1"
/translation="MVSRYSAYRRGPDVISPDVIDRILVGACAAVWLVFTGVSVAAAV
ALMDLGRGFHEMAGNPHTTWVLYAVIVVSALVIVGAIPVLLRARRMAEAEPATRPTGA
SVRGGRSIGSGHPAKRAVAESAPVQHADAFEVAAEWSSEAVDRIWLRGTVVLTSAIGI
ALIAVAAATYLMAVGHDGPSWISYGLAGVVTAGMPVIEWLYARQLRRVVAPQSS"
gene complement(2462148..2463047)
/gene="mmpS3"
/locus_tag="Rv2198c"
CDS complement(2462148..2463047)
/codon_start=1
/transl_table=11
/gene="mmpS3"
/locus_tag="Rv2198c"
/product="Probable conserved membrane protein MmpS3"
/note="Rv2198c, (MTCY190.09c), len: 299 aa. Probable
mmpS3,conserved membrane protein (see citation below),
equivalent to ML0877|mmpS3 putative membrane protein from
Mycobacterium leprae (293 aa), FASTA scores: opt:
1089,E(): 1.2e-43, (69.80% identity in 308 aa overlap).
Also similar to other proteins e.g. Rv3209 from
Mycobacterium tuberculosis. Contains PS00499 C2 domain
signature, a hydrophobic region, and a repetitive proline
and threonine rich region. Belongs to the MmpS family. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2198c"
/db_xref="EnsemblGenomes-Tr:CCP44975"
/db_xref="GOA:P9WJT1"
/db_xref="InterPro:IPR008693"
/db_xref="InterPro:IPR038468"
/db_xref="UniProtKB/Swiss-Prot:P9WJT1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44975.1"
/translation="MSGPNPPGREPDEPESEPVSDTGDERASGNHLPPVAGGGDKLPS
DQTGETDAYSRAYSAPESEHVTGGPYVPADLRLYDYDDYEESSDLDDELAAPRWPWVV
GVAAIIAAVALVVSVSLLVTRPHTSKLATGDTTSSAPPVQDEITTTKPAPPPPPPAPP
PTTEIPTATETQTVTVTPPPPPPPATTTAPPPATTTTAAAPPPTTTTPTGPRQVTYSV
TGTKAPGDIISVTYVDAAGRRRTQHNVYIPWSMTVTPISQSDVGSVEASSLFRVSKLN
CSITTSDGTVLSSNSNDGPQTSC"
gene complement(2463233..2463652)
/locus_tag="Rv2199c"
CDS complement(2463233..2463652)
/codon_start=1
/transl_table=11
/locus_tag="Rv2199c"
/product="Possible conserved integral membrane protein"
/note="Rv2199c, (MTCY190.10c), len: 139 aa. Possible
conserved integral membrane protein, similar to
hypothetical membrane proteins in Actinomycetes and
equivalent to Mycobacterium leprae, ML0876, putative
membrane protein (139 aa) FASTA scores: opt: 866, E():
1.1e-43; 91.367% identity in 139 aa overlap CAC31257.1|
(AL583920)"
/db_xref="EnsemblGenomes-Gn:Rv2199c"
/db_xref="EnsemblGenomes-Tr:CCP44976"
/db_xref="GOA:P9WP45"
/db_xref="InterPro:IPR021050"
/db_xref="UniProtKB/Swiss-Prot:P9WP45"
/protein_id="CCP44976.1"
/translation="MHIEARLFEFVAAFFVVTAVLYGVLTSMFATGGVEWAGTTALAL
TGGMALIVATFFRFVARRLDSRPEDYEGAEISDGAGELGFFSPHSWWPIMVALSGSVA
AVGIALWLPWLIAAGVAFILASAAGLVFEYYVGPEKH"
gene complement(2463660..2464751)
/gene="ctaC"
/locus_tag="Rv2200c"
CDS complement(2463660..2464751)
/codon_start=1
/transl_table=11
/gene="ctaC"
/locus_tag="Rv2200c"
/product="Probable transmembrane cytochrome C oxidase
(subunit II) CtaC"
/note="Rv2200c, (MTCY190.11c), len: 363 aa. Probable
ctaC,transmembrane cytochrome C oxidase (subunit II),
COX2,similar e.g. to JT0964 cytochrome-c oxidase chain II
(23.0% identity in 317 aa overlap); etc. Contains PS00078
Cytochrome c oxidase subunit II, copper a binding region
signature. Belongs to the cytochrome C oxidase subunit 2
family."
/db_xref="EnsemblGenomes-Gn:Rv2200c"
/db_xref="EnsemblGenomes-Tr:CCP44977"
/db_xref="GOA:P9WP69"
/db_xref="InterPro:IPR001505"
/db_xref="InterPro:IPR002429"
/db_xref="InterPro:IPR008972"
/db_xref="InterPro:IPR036257"
/db_xref="UniProtKB/Swiss-Prot:P9WP69"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44977.1"
/translation="MTPRGPGRLQRLSQCRPQRGSGGPARGLRQLALAAMLGALAVTV
SGCSWSEALGIGWPEGITPEAHLNRELWIGAVIASLAVGVIVWGLIFWSAVFHRKKNT
DTELPRQFGYNMPLELVLTVIPFLIISVLFYFTVVVQEKMLQIAKDPEVVIDITSFQW
NWKFGYQRVNFKDGTLTYDGADPERKRAMVSKPEGKDKYGEELVGPVRGLNTEDRTYL
NFDKVETLGTSTEIPVLVLPSGKRIEFQMASADVIHAFWVPEFLFKRDVMPNPVANNS
VNVFQIEEITKTGAFVGHCAEMCGTYHSMMNFEVRVVTPNDFKAYLQQRIDGKTNAEA
LRAINQPPLAVTTHPFDTRRGELAPQPVG"
gene 2464997..2466955
/gene="asnB"
/locus_tag="Rv2201"
CDS 2464997..2466955
/codon_start=1
/transl_table=11
/gene="asnB"
/locus_tag="Rv2201"
/product="Probable asparagine synthetase AsnB"
/note="Rv2201, (MTCY190.12), len: 652 aa. Probable
asnB,asparagine synthetase, similar to e.g. SW:ASNH_BACSU
P42113 putative asparagine synthetase (26.0% identity in
438 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2201"
/db_xref="EnsemblGenomes-Tr:CCP44978"
/db_xref="GOA:P9WN33"
/db_xref="InterPro:IPR001962"
/db_xref="InterPro:IPR006426"
/db_xref="InterPro:IPR017932"
/db_xref="InterPro:IPR029055"
/db_xref="InterPro:IPR033738"
/db_xref="UniProtKB/Swiss-Prot:P9WN33"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44978.1"
/translation="MCGLLAFVAAPAGAAGPEGADAASAIARASHLMRHRGPDESGTW
HAVDGASGGVVFGFNRLSIIDIAHSHQPLRWGPPEAPDRYVLVFNGEIYNYLELRDEL
RTQHGAVFATDGDGEAILAGYHHWGTEVLQRLRGMFAFALWDTVTRELFCARDPFGIK
PLFIATGAGGTAVASEKKCLLDLVELVGFDTEIDHRALQHYTVLQYVPEPETLHRGVR
RLESGCFARIRADQLAPVITRYFVPRFAASPITNDNDQARYDEITAVLEDSVAKHMRA
DVTVGAFLSGGIDSTAIAALAIRHNPRLITFTTGFEREGFSEIDVAVASAEAIGARHI
AKVVSADEFVAALPEIVWYLDEPVADPALVPLFFVAREARKHVKVVLSGEGADELFGG
YTIYREPLSLRPFDYLPKPLRRSMGKVSKPLPEGMRGKSLLHRGSLTLEERYYGNARS
FSGAQLREVLPGFRPDWTHTDVTAPVYAESAGWDPVARMQHIDLFTWLRGDILVKADK
ITMANSLELRVPFLDPEVFAVASRLPAGAKITRTTTKYALRRALEPIVPAHVLHRPKL
GFPVPIRHWLRAGELLEWAYATVGSSQAGHLVDIAAVYRMLDEHRCGSSDHSRRLWTM
LIFMLWHAIFVEHSVVPQISEPQYPVQL"
gene complement(2467053..2468027)
/gene="adoK"
/locus_tag="Rv2202c"
CDS complement(2467053..2468027)
/codon_start=1
/transl_table=11
/gene="adoK"
/locus_tag="Rv2202c"
/product="Adenosine kinase"
/note="Rv2202c, (MTCY190.13c), len: 324 aa. AdoK,
Adenosine kinase activity proven biochemically (See Long
et al. 2003). Similar to several others but shows greater
sequence homology with ribokinase and fructokinase than it
does with other AKs e.g. AE000915_1 Methanobacterium
thermoautotrop (309 aa) FASTA score: opt: 370, E():
3.3e-18; 31.2% identity in 276 aa overlap. Low similarity
to carbohydrate kinases, e.g. SW:RBSK_BACSU P36945
ribokinase (23.9% identity in 272 aa overlap); contains
PS00583 pfkB family of carbohydrate kinases signature 1.
Previously known as cbhK"
/db_xref="EnsemblGenomes-Gn:Rv2202c"
/db_xref="EnsemblGenomes-Tr:CCP44979"
/db_xref="GOA:P9WID5"
/db_xref="InterPro:IPR002173"
/db_xref="InterPro:IPR011611"
/db_xref="InterPro:IPR029056"
/db_xref="PDB:2PKF"
/db_xref="PDB:2PKK"
/db_xref="PDB:2PKM"
/db_xref="PDB:2PKN"
/db_xref="PDB:4O1G"
/db_xref="PDB:4PVV"
/db_xref="PDB:6C67"
/db_xref="PDB:6C9N"
/db_xref="PDB:6C9P"
/db_xref="PDB:6C9Q"
/db_xref="PDB:6C9R"
/db_xref="PDB:6C9S"
/db_xref="PDB:6C9V"
/db_xref="UniProtKB/Swiss-Prot:P9WID5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44979.1"
/translation="MTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVM
HRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARF
TCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECR
KLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQID
LRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERS
AQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVLA"
gene 2468231..2468923
/locus_tag="Rv2203"
CDS 2468231..2468923
/codon_start=1
/transl_table=11
/locus_tag="Rv2203"
/product="Possible conserved membrane protein"
/note="Rv2203, (MTCY190.14), len: 230 aa. Possible
conserved membrane protein; has single hydrophobic stretch
from aa 75 to 97 and is equivalent to Mycobacterium leprae
ML0872 putative membrane protein (171 aa). FASTA scores:
opt: 821, E(): 3.4e-42; 72.353% identity in 170 aa overlap
- CAC31253.1| (AL583920). 2468411. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2203"
/db_xref="EnsemblGenomes-Tr:CCP44980"
/db_xref="GOA:P9WLI7"
/db_xref="UniProtKB/Swiss-Prot:P9WLI7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44980.1"
/translation="MPGPHSPNPGVGTNGPAPYPEPSSHEPQALDYPHDLGAAEPAFA
PGPADDAALPPAAYPGVPPQVSYPKRRHKRLLIGIVVALALVSAMTAAIIYGVRTNGA
NTAGTFSEGPAKTAIQGYLNALENRDVDTIVRNALCGIHDGVRDKRSDQALAKLSSDA
FRKQFSQVEVTSIDKIVYWSQYQAQVLFTMQVTPAAGGPPRGQVQGIAQLLFQRGQVL
VCSYVLRTAGSY"
gene complement(2468931..2469287)
/locus_tag="Rv2204c"
CDS complement(2468931..2469287)
/codon_start=1
/transl_table=11
/locus_tag="Rv2204c"
/product="Conserved protein"
/note="Rv2204c, (MTCY190.15c), len: 118 aa. Conserved
protein. Similar to conserved hypothetical proteins in
Actinomycetes and equivalent to Mycobacterium leprae
ML0871|ML0871 conserved hypothetical protein (118 aa) and
to sp|P45344|YADR_HAEIN hypothetical protein HI1723 (114
aa). FASTA score: ML0871 opt: 720, E(): 8.4e-45; 92.373%
identity in 118 aa overlapCAC31252.1| (AL583920); and
P45344 opt: 346, E(): 1.8e-18; 45.6% identity in 103 aa
overlap. Contains PS01152 Hypothetical hesB/y yadR/yfhF
family signature"
/db_xref="EnsemblGenomes-Gn:Rv2204c"
/db_xref="EnsemblGenomes-Tr:CCP44981"
/db_xref="GOA:P9WMN5"
/db_xref="InterPro:IPR000361"
/db_xref="InterPro:IPR016092"
/db_xref="InterPro:IPR017870"
/db_xref="InterPro:IPR035903"
/db_xref="UniProtKB/Swiss-Prot:P9WMN5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44981.1"
/translation="MTVQNEPSAKTHGVILTEAAAAKAKSLLDQEGRDDLALRIAVQP
GGCAGLRYNLFFDDRTLDGDQTAEFGGVRLIVDRMSAPYVEGASIDFVDTIEKQGFTI
DNPNATGSCACGDSFN"
gene complement(2469387..2470463)
/locus_tag="Rv2205c"
CDS complement(2469387..2470463)
/codon_start=1
/transl_table=11
/locus_tag="Rv2205c"
/product="Conserved hypothetical protein"
/note="Rv2205c, (MTCY190.16c), len: 358 aa. Conserved
hypothetical protein. Very similar to YHAD_ECOLI|P23524
hypothetical protein (YHAD (E.coli) / YXAA (S14A)
(B.subtilis) family) (41.6% identity in 154 aa
overlap),and to other members of the glycerate kinase
family. Start changed since first submission; protein now
122 aa shorter,owing to extension of Rv2206. Nucleotide
position 2470149 in the genome sequence has been
corrected, T:C resulting in E105E."
/db_xref="EnsemblGenomes-Gn:Rv2205c"
/db_xref="EnsemblGenomes-Tr:CCP44982"
/db_xref="GOA:P9WMT7"
/db_xref="InterPro:IPR004381"
/db_xref="InterPro:IPR018193"
/db_xref="InterPro:IPR018197"
/db_xref="InterPro:IPR036129"
/db_xref="UniProtKB/Swiss-Prot:P9WMT7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44982.1"
/translation="MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDG
GPGFVEVLGSRLGETRRLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPP
TPETALAAHSKGVGQLIAAALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQL
ADVEVIAASDVEYPLLGPWGTARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGV
SAEPGAGAAGGIGAGLLAVGGRYQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSL
HGKVVGAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMAALSIAEYAGSVRLALADA
ANQLMGLASQVAARLGNSGPSGYR"
gene 2470622..2471332
/locus_tag="Rv2206"
CDS 2470622..2471332
/codon_start=1
/transl_table=11
/locus_tag="Rv2206"
/product="Probable conserved transmembrane protein"
/note="Rv2206, (MTCY190.17), len: 236 aa. Probable
conserved transmembrane protein. Equivalent to
hypothetical protein ML0869 (247 aa) of Mycobacterium
leprae gZ98741|MLCB22_2 (247 aa), FASTA scores: opt: 1052,
(67.5% identity in 237 aa overlap). Two hydrophobic
stretches in C-terminal part. Start changed since original
submission (+112 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2206"
/db_xref="EnsemblGenomes-Tr:CCP44983"
/db_xref="GOA:P9WLI5"
/db_xref="InterPro:IPR021403"
/db_xref="UniProtKB/Swiss-Prot:P9WLI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44983.1"
/translation="MKLLGHRKSHGHQRADASPDAGSKDGCRPDSGRTSGSDTSRGSQ
TTGPKGRPTPKRNQSRRHTKKGPVAPAPMTAAQARARRKSLAGPKLSREERRAEKAAN
RARMTERRERMMAGEEAYLLPRDRGPVRRYVRDVVDSRRNLLGLFMPSALTLLFVMFA
VPQVQFYLSPAMLILLALMTIDAIILGRKVGRLVDTKFPSNTESRWRLGLYAAGRASQ
IRRLRAPRPQVERGGDVG"
gene 2471411..2472496
/gene="cobT"
/locus_tag="Rv2207"
CDS 2471411..2472496
/codon_start=1
/transl_table=11
/gene="cobT"
/locus_tag="Rv2207"
/product="Probable nicotinate-nucleotide-
dimethylbenzimidazol phosphoribosyltransferase CobT"
/note="Rv2207, (MTCY190.18), len: 361 aa. Probable
cobT,phosphoribosyltransferase, similar to many e.g.
SW:COBT_ECOLI P36562
nicotinate-nucleotide--dimethylbenzimidazol
phosphoribosyltransferase (34.6% identity in 341 aa
overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2207"
/db_xref="EnsemblGenomes-Tr:CCP44984"
/db_xref="GOA:P9WP85"
/db_xref="InterPro:IPR003200"
/db_xref="InterPro:IPR017846"
/db_xref="InterPro:IPR023195"
/db_xref="InterPro:IPR036087"
/db_xref="UniProtKB/Swiss-Prot:P9WP85"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44984.1"
/translation="MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVAS
CQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGGAAINALADVA
GATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDALTNDETAAAITAGQQIADEEV
DAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARKTAAVRDAL
FRVRPVLPDPVGLLRCAGGADLAAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAP
GAHRWWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSS
MATFTEAGVSTRSVDGVDRTAPPAVSP"
gene 2472493..2473242
/gene="cobS"
/locus_tag="Rv2208"
CDS 2472493..2473242
/codon_start=1
/transl_table=11
/gene="cobS"
/locus_tag="Rv2208"
/product="Probable cobalamin 5'-phosphate synthase CobS"
/note="Rv2208, (MTCY190.19), len: 249 aa. Probable
cobS,cobalamin 5'-phosphate synthase; similarity to
SW:COBS_ECOLI P36561 cobalamin (5'-phosphate) synthase
(28.0% identity in 243 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2208"
/db_xref="EnsemblGenomes-Tr:CCP44985"
/db_xref="GOA:P9WP91"
/db_xref="InterPro:IPR003805"
/db_xref="UniProtKB/Swiss-Prot:P9WP91"
/protein_id="CCP44985.1"
/translation="MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALA
AAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVM
RDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAH
GSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVH
RFGGVTGDVLGSAIELSTTVSAVTLAGLARL"
gene 2473400..2474938
/locus_tag="Rv2209"
CDS 2473400..2474938
/codon_start=1
/transl_table=11
/locus_tag="Rv2209"
/product="Probable conserved integral membrane protein"
/note="Rv2209, (MTCY190.20), len: 512 aa. Probable
conserved integral membrane protein, similar to but longer
than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium
tuberculosis (436 aa). FASTA score: opt: 712, E():
2.8e-32; 33.4% identity in 422 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2209"
/db_xref="EnsemblGenomes-Tr:CCP44986"
/db_xref="GOA:P9WLI3"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WLI3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44986.1"
/translation="MPASRLVRQVSAPRNLFGRLVAQGGFYTAGLQLGSGAVVLPVIC
AHQGLTWAAGLLYPAFCIGAILGNSLSPLILQRAGQLRHLLMAAISATAAALVVCNAA
VPWTGVGVAAVFLATTGAGGVVTGVSSVAYTDMISSMLPAVRRGELLLTQGAAGSVLA
TGVTLVIVPMLAHGNEMARYHDLLWLGAAGLVCSGIAALFVGPMRSVSVTTATRMPLR
EIYWMGFAIARSQPWFRRYMTTYLLFVPISLGTTFFSLRAAQSNGSLHVLVILSSIGL
VVGSMLWRQINRLFGVRGLLLGSALLNAAAALLCMVAESCGQWVHAWAYGTAFLLATV
AAQTVVAASISWISVLAPERYRATLICVGSTLAAVEATVLGVALGGIAQKHATIWPVV
VVLTLAVIAAVASLRAPTRIGVTADTSPQAATLQAYRPATPNPIHSDERSTPPDHLSV
RRGQLRHVWDSRRPAPPLNRPSCRRAARRPAPGKPAAALPQPRHPAVGVREGAPLDAG
QRIA"
gene complement(2474864..2475970)
/gene="ilvE"
/locus_tag="Rv2210c"
CDS complement(2474864..2475970)
/codon_start=1
/transl_table=11
/gene="ilvE"
/locus_tag="Rv2210c"
/product="Branched-chain amino acid transaminase IlvE"
/note="Rv2210c, (MTCY190.21c), len: 368 aa.
ilvE,Branched-chain-amino-acid transaminase, highly
similar to many e.g. YWAA_BACSU|P39576 from Bacillus
subtilis (48.4% identity in 339 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2210c"
/db_xref="EnsemblGenomes-Tr:CCP44987"
/db_xref="GOA:P9WQ75"
/db_xref="InterPro:IPR001544"
/db_xref="InterPro:IPR005786"
/db_xref="InterPro:IPR018300"
/db_xref="InterPro:IPR033939"
/db_xref="InterPro:IPR036038"
/db_xref="PDB:3HT5"
/db_xref="PDB:5U3F"
/db_xref="UniProtKB/Swiss-Prot:P9WQ75"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44987.1"
/translation="MTSGSLQFTVLRAVNPATDAQRESMLREPGFGKYHTDHMVSIDY
AEGRGWHNARVIPYGPIELDPSAIVLHYAQEVFEGLKAYRWADGSIVSFRADANAARL
RSSARRLAIPELPDAVFIESLRQLIAVDKAWVPGAGGEEALYLRPFIFATEPGLGVRP
ATQYRYLLIASPAGAYFKGGIAPVSVWVSTEYVRACPGGTGAAKFGGNYAASLLAQAE
AAENGCDQVVWLDAVERRYIEEMGGMNIFFVLGSGGSARLVTPELSGSLLPGITRDSL
LQLAIDAGFAVEERRIDIDEWQKKAAAGEITEVFACGTAAVITPVARVRHGASEFRIA
DGQPGEVTMALRDTLTGIQRGTFADTHGWMARLG"
gene complement(2476042..2477181)
/gene="gcvT"
/locus_tag="Rv2211c"
CDS complement(2476042..2477181)
/codon_start=1
/transl_table=11
/gene="gcvT"
/locus_tag="Rv2211c"
/product="Probable aminomethyltransferase GcvT (glycine
cleavage system T protein)"
/note="Rv2211c, (MTCY190.22), len: 379 aa. Probable
gcvT,aminomethyltransferase, similar to many e.g.
GCST_ECOLI|P27248 for Escherichia coli (38.2% identity in
364 aa overlap); etc. Belongs to the GcvT family."
/db_xref="EnsemblGenomes-Gn:Rv2211c"
/db_xref="EnsemblGenomes-Tr:CCP44988"
/db_xref="GOA:P9WN51"
/db_xref="InterPro:IPR006222"
/db_xref="InterPro:IPR006223"
/db_xref="InterPro:IPR013977"
/db_xref="InterPro:IPR022903"
/db_xref="InterPro:IPR027266"
/db_xref="InterPro:IPR028896"
/db_xref="InterPro:IPR029043"
/db_xref="UniProtKB/Swiss-Prot:P9WN51"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44988.1"
/translation="MCQQGRPLGWDAVSDVPELIHGPLEDRHRELGASFAEFGGWLMP
VSYAGTVSEHNATRTAVGLFDVSHLGKALVRGPGAAQFVNSALTNDLGRIGPGKAQYT
LCCTESGGVIDDLIAYYVSDDEIFLVPNAANTAAVVGALQAAAPGGLSITNLHRSYAV
LAVQGPCSTDVLTALGLPTEMDYMGYADASYSGVPVRVCRTGYTGEHGYELLPPWESA
GVVFDALLAAVSAAGGEPAGLGARDTLRTEMGYPLHGHELSLDISPLQARCGWAVGWR
KDAFFGRAALLAEKAAGPRRLLRGLRMVGRGVLRPGLAVLVGDETVGVTTSGTFSPTL
QVGIGLALIDSDAGIEDGQQINVDVRGRAVECQVVCPPFVAVKTR"
gene 2477190..2478326
/locus_tag="Rv2212"
CDS 2477190..2478326
/codon_start=1
/transl_table=11
/locus_tag="Rv2212"
/product="Adenylyl cyclase (ATP pyrophosphate-lyase)
(adenylate cyclase)"
/note="Rv2212, (MTCY190.23), len: 378 aa. Adenylyl cyclase
(See Abdel Motaal et al., 2006). Some similarity to e.g.
SW:CYAA_STRCO P40135 adenylate cyclase (29.2% identity in
291 aa overlap); ttg at 24614 in MTCY190 has a better rbs.
Contains possible helix-turn-helix motif at aa
64-85,(+2.72 SD). Also similar to Rv1264 and Rv1647"
/db_xref="EnsemblGenomes-Gn:Rv2212"
/db_xref="EnsemblGenomes-Tr:CCP44989"
/db_xref="GOA:P9WMU7"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR032026"
/db_xref="UniProtKB/Swiss-Prot:P9WMU7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44989.1"
/translation="MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERR
GRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQAD
VDALATWVALKALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELA
TARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFT
ALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDL
VDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDM
LPDWPALAHGPLTLKGFDAPVMAFELHDNPRARDADTPSPAASD"
gene 2478338..2479885
/gene="pepB"
/locus_tag="Rv2213"
CDS 2478338..2479885
/codon_start=1
/transl_table=11
/gene="pepB"
/locus_tag="Rv2213"
/product="Probable aminopeptidase PepB"
/note="Rv2213, (MTCY190.24), len: 515 aa. Probable
pepB,leucine aminopeptidase, similar to many e.g.
SW:AMPA_ECOLI P11648 aminopeptidase a/I, (41.4% identity
in 309 aa overlap). Equivalent to Z98741|MLCB22_6
Mycobacterium leprae cosmid B22; Am (524 aa), FASTA
scores: opt: 2793,E(): 0; 83.1% identity in 522 aa
overlap. Contains PS00631 Cytosol aminopeptidase
signature, ntdaegrl. Conserved in M. tuberculosis, M.
leprae, M. bovis and M. avium paratuberculosis; predicted
to be essential for in vivo survival and pathogenicity
(See Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2213"
/db_xref="EnsemblGenomes-Tr:CCP44990"
/db_xref="GOA:P9WHT3"
/db_xref="InterPro:IPR000819"
/db_xref="InterPro:IPR008283"
/db_xref="InterPro:IPR011356"
/db_xref="InterPro:IPR023042"
/db_xref="UniProtKB/Swiss-Prot:P9WHT3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44990.1"
/translation="MTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAV
VASAEPFLRADTVAEIEAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWP
ADTIRCAAGVAARALNSSEAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAP
KDAGLRKITVLCCAKDAKKRALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLS
ESVGLDVEVIDEKALKKAGYGGVIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVAL
VGKGITFDTGGISIKPAASMHHMTSDMGGAAAVIATVTLAARLRLPIDVIATVPMAEN
MPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDKPDYLIETSTLTGA
QTVALGTRIPGVMGSDEFRDRVAAISQRVGENGWPMPLPDDLKDDLKSTVADLANVSG
QRFAGMLVAGVFLREFVAESVDWAHIDVAGPAYNTGSAWGYTPKGATGVPTRTMFAVL
EDIAKNG"
gene complement(2479923..2481701)
/gene="ephD"
/locus_tag="Rv2214c"
CDS complement(2479923..2481701)
/codon_start=1
/transl_table=11
/gene="ephD"
/locus_tag="Rv2214c"
/product="Possible short-chain dehydrogenase EphD"
/note="Rv2214c, (MTCY190.25c), len: 592 aa. Possible
ephD,short-chain dehydrogenase (see citation below),
equivalent to Z98741|MLCB22_8 Mycobacterium leprae cosmid
B22; (596 aa), FASTA score: opt: 3262, E(): 0; 80.4%
identity in 596 aa overlap. C-terminus similar to
short-chain alcohol dehydrogenase family, similar to
SW:LIGD_PSEPA Q01198 c alpha-dehydrogenase (30.7% identity
in 241 aa overlap); contains PS00061 Short-chain alcohol
dehydrogenase family signature, PS00697 ATP-dependent DNA
ligase AMP-binding site. N-terminus corresponds to several
epoxide hydrolases of plants and Mycobacterium
tuberculosis e.g. MTCY9F925"
/db_xref="EnsemblGenomes-Gn:Rv2214c"
/db_xref="EnsemblGenomes-Tr:CCP44991"
/db_xref="GOA:P9WGS3"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44991.1"
/translation="MPATQQMSRLVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVL
WDGVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSPGEPVHV
LAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGGLRRPWRPRTFLRAI
SQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDIPVDQIHHSETLARDAAHSV
KTYPANYFRSFSSSRRGRAIPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDI
KAGHFSPMSHPQVMAAAVHDFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGS
GIGRETALAFAREGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFA
ERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQRLVER
GTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAGVGLTTICPGVID
TNIVATTGFHAPGTDEEKIDGRRGQIDKMFALRSYGPDKVADAIVSAVKKKKPIRPVA
PEAYALYGISRVLPQALRSTARLRVI"
gene 2481965..2483626
/gene="dlaT"
/locus_tag="Rv2215"
CDS 2481965..2483626
/codon_start=1
/transl_table=11
/gene="dlaT"
/locus_tag="Rv2215"
/product="DlaT, dihydrolipoamide acyltransferase, E2
component of pyruvate dehydrogenase"
/note="Rv2215, (MTCY190.26), len: 553 aa.
DlaT,dihydrolipoamide acyltransferase, E2 component of
pyruvate dehydrogenase, proven biochemically (see Tian et
al. 2005),similar to e.g. SW:O PD2_ACHLA P35489
dihydrolipoamide acetyltransferase component (E2) of
pyruvate dehydrogenase complex (35.3% identity in 552 aa
overlap); contains PS00189 2-oxo acid dehydrogenases
acyltransferase component lipoyl binding site. Rhodanine
compounds inhibit DlaT|Rv2215 and can kill non-replicating
mycobacteria in mouse bone marrow-derived macrophages (See
Bryk et al.,2008). LpdC|Rv0462 co-immunoprecipitates with
DlaT|Rv2215 (in lpdC|Rv0462 mutant) and with BkdC|Rv2495c
(in dlaT|Rv2215 mutant) (See Venugopal et al., 2011)."
/db_xref="EnsemblGenomes-Gn:Rv2215"
/db_xref="EnsemblGenomes-Tr:CCP44992"
/db_xref="GOA:P9WIS7"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR001078"
/db_xref="InterPro:IPR003016"
/db_xref="InterPro:IPR004167"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR014276"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR036625"
/db_xref="UniProtKB/Swiss-Prot:P9WIS7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44992.1"
/translation="MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKV
DTEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKP
APEPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVST
DKVDTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPA
PTPKAEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDV
LAAAEQKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQKASRIRQITANKTRE
SLQATAQLTQTHEVDMTKIVGLRARAKAAFAEREGVNLTFLPFFAKAVIDALKIHPNI
NASYNEDTKEITYYDAEHLGFAVDTEQGLLSPVIHDAGDLSLAGLARAIADIAARARS
GNLKPDELSGGTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPRVVVDASGNES
IGVRSVCYLPLTYDHRLIDGADAGRFLTTIKHRLEEGAFEADLGL"
gene 2483626..2484531
/locus_tag="Rv2216"
CDS 2483626..2484531
/codon_start=1
/transl_table=11
/locus_tag="Rv2216"
/product="Conserved protein"
/note="Rv2216, (MTCY190.27), len: 301 aa. Conserved
protein, equivalent to Mycobacterium leprae ML0860 (307
aa), Z98741|MLCB22_10 Mycobacterium leprae cosmid B22; H
(307 aa). FASTA score: opt: 1656, E(): 0; 84.2% identity
in 297 aa overlap. Also gp|AE000319|ECAE000319_8
Escherichia coli strain K12 MG1655 (297 aa) opt: 640, E():
0; 39.5% identity in 294 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2216"
/db_xref="EnsemblGenomes-Tr:CCP44993"
/db_xref="GOA:P9WGP7"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR010099"
/db_xref="InterPro:IPR013549"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44993.1"
/translation="MANAVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEEL
HWNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSAAVAD
AGVATLINASAVGYYGNTKDRVVDENDSAGTGFLAQLCVDWETATRPAQQSGARVVLA
RTGVVLSPAGGMLRRMRPLFSVGLGARLGSGRQYMSWISLEDEVRALQFAIAQPNLSG
PVNLTGPAPVTNAEFTTAFGRAVNRPTPLMLPSVAVRAAFGEFADEGLLIGQRAIPSA
LERAGFQFHHNTIGEALGYATTRPG"
gene 2484584..2485276
/gene="lipB"
/locus_tag="Rv2217"
CDS 2484584..2485276
/codon_start=1
/transl_table=11
/gene="lipB"
/locus_tag="Rv2217"
/product="Probable lipoate biosynthesis protein B LipB"
/note="Rv2217, (MTCY190.28), len: 230 aa. Probable
lipB,similar to SW:LIPB_ECOLI P30976 liopate biosynthesis
protein B (33.8% identity in 160 aa overlap). Equivalent
to gp|Z98741| MLCB22_11 Mycobacterium leprae (235 aa).
FASTA score: opt: 1124, E(): 0; 78.4% identity in 218 aa
overlap"
/db_xref="EnsemblGenomes-Gn:Rv2217"
/db_xref="EnsemblGenomes-Tr:CCP44994"
/db_xref="GOA:P9WK83"
/db_xref="InterPro:IPR000544"
/db_xref="InterPro:IPR004143"
/db_xref="InterPro:IPR020605"
/db_xref="PDB:1W66"
/db_xref="UniProtKB/Swiss-Prot:P9WK83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44994.1"
/translation="MTGSIRSKLSAIDVRQLGTVDYRTAWQLQRELADARVAGGADTL
LLLEHPAVYTAGRRTETHERPIDGTPVVDTDRGGKITWHGPGQLVGYPIIGLAEPLDV
VNYVRRLEESLIQVCADLGLHAGRVDGRSGVWLPGRPARKVAAIGVRVSRATTLHGFA
LNCDCDLAAFTAIVPCGISDAAVTSLSAELGRTVTVDEVRATVAAAVCAALDGVLPVG
DRVPSHAVPSPL"
gene 2485273..2486208
/gene="lipA"
/locus_tag="Rv2218"
CDS 2485273..2486208
/codon_start=1
/transl_table=11
/gene="lipA"
/locus_tag="Rv2218"
/product="Probable lipoate biosynthesis protein A LipA"
/note="Rv2218, (MTCY190.29), len: 311 aa. Probable
lipA,lipoic acid synthetase, similar to e.g. SW:LIPA_HAEIN
P44463 (42.6% identity in 291 aa overlap). Equivalent to
Z98741|MLCB2 2_12 Mycobacterium leprae cosmid B22; (314
aa). FASTA score : opt: 1836, E(): 0; 86.8% identity in
310 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2218"
/db_xref="EnsemblGenomes-Tr:CCP44995"
/db_xref="GOA:P9WK91"
/db_xref="InterPro:IPR003698"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR031691"
/db_xref="PDB:5EXI"
/db_xref="PDB:5EXJ"
/db_xref="PDB:5EXK"
/db_xref="UniProtKB/Swiss-Prot:P9WK91"
/protein_id="CCP44995.1"
/translation="MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKN
LVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAELDRDE
PRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATVRAIKELNPSTGVELLIPDFN
GEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDAGLVTKSNL
ILGLGETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAE
GLGFAGVLAGPLVRSSYRAGRLYEQARNSRALASR"
gene 2486235..2486987
/locus_tag="Rv2219"
CDS 2486235..2486987
/codon_start=1
/transl_table=11
/locus_tag="Rv2219"
/product="Probable conserved transmembrane protein"
/note="Rv2219, (MTCY190.30), len: 250 aa. Probable
conserved transmembrane protein. Equivalent to
hypothetical membrane protein ML0857 (250 aa) from
Mycobacterium leprae Z98741 |MLCB22_13 Mycobacterium
leprae cosmid B22; H (250 aa) opt : 1328, E(): 0; 80.8%
identity in 250 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2219"
/db_xref="EnsemblGenomes-Tr:CCP44996"
/db_xref="GOA:P9WLI1"
/db_xref="InterPro:IPR025445"
/db_xref="UniProtKB/Swiss-Prot:P9WLI1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44996.1"
/translation="MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDK
RLLPYMIGAFLLIVGASVGVGVWAGGFTMFTMIPLGVLLGALVAFVIFGRRAQRTVYR
KAEGQTGAAAWALDNLRGKWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPL
LAQEKKRTARLVGDVPIYDIIVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLA
ALGSRAGAGVMPKGPLPTTAKMRSVQRTVRRK"
gene complement(2486994..2487416)
/locus_tag="Rv2219A"
CDS complement(2486994..2487416)
/codon_start=1
/transl_table=11
/locus_tag="Rv2219A"
/product="Probable conserved membrane protein"
/note="Rv2219A, len: 140 aa. Probable conserved membrane
protein, similar to SC3H12.05c|AL355740_5 possible
integral membrane protein from Streptomyces coelicolor
(155 aa),FASTA scores: opt: 327, E(): 7.5e-14, (46.6%
identity in 133 aa overlap), also linked to glnA."
/db_xref="EnsemblGenomes-Gn:Rv2219A"
/db_xref="EnsemblGenomes-Tr:CCP44997"
/db_xref="GOA:Q79FG7"
/db_xref="InterPro:IPR010432"
/db_xref="InterPro:IPR016795"
/db_xref="UniProtKB/TrEMBL:Q79FG7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44997.1"
/translation="MTAKSPPDYPGKTLGLPDTGPGSLAPMGRRLAALLIDWLIAYGL
ALLGVEFGVWSTPMLSTVVLVIWLLLGVAAVRLFGFTPGQLMLGLVVVAVGGRRPVGI
GRLVVRGLLIGLVVPPLFTDSDGRGLHDRLTATAVVRR"
gene 2487615..2489051
/gene="glnA1"
/gene_synonym="glnA"
/locus_tag="Rv2220"
CDS 2487615..2489051
/codon_start=1
/transl_table=11
/gene="glnA1"
/gene_synonym="glnA"
/locus_tag="Rv2220"
/product="Glutamine synthetase GlnA1 (glutamine synthase)
(GS-I)"
/note="Rv2220, (MTCY190.31, MTCY427.01), len: 478 aa.
glnA1, glutamine synthetase class I (see Tullius et
al.,2001), similar to many e.g. GLNA_STRCO|P15106 from
Streptomyces coelicolor, FASTA score: (71.4% identity in
475 aa overlap); etc. Also similar to three other
potential glutamine synthetases in Mycobacterium
tuberculosis: Rv2222c|glnA2, Rv2860c|glnA4, and
Rv1878|glnA3. Contains PS00180 Glutamine synthetase
signature 1, PS00181 Glutamine synthetase putative
ATP-binding region signature, and PS00182 Glutamine
synthetase class-I adenylation site. Belongs to the
glutamine synthetase family. Note has shown to be
essential for M. tuberculosis virulence."
/db_xref="EnsemblGenomes-Gn:Rv2220"
/db_xref="EnsemblGenomes-Tr:CCP44998"
/db_xref="GOA:P9WN39"
/db_xref="InterPro:IPR001637"
/db_xref="InterPro:IPR004809"
/db_xref="InterPro:IPR008146"
/db_xref="InterPro:IPR008147"
/db_xref="InterPro:IPR014746"
/db_xref="InterPro:IPR027302"
/db_xref="InterPro:IPR027303"
/db_xref="InterPro:IPR036651"
/db_xref="PDB:1HTO"
/db_xref="PDB:1HTQ"
/db_xref="PDB:2BVC"
/db_xref="PDB:2WGS"
/db_xref="PDB:2WHI"
/db_xref="PDB:3ZXR"
/db_xref="PDB:3ZXV"
/db_xref="PDB:4ACF"
/db_xref="PDB:4XYC"
/db_xref="UniProtKB/Swiss-Prot:P9WN39"
/inference="protein motif:PROSITE:PS00181"
/inference="protein motif:PROSITE:PS00182"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44998.1"
/translation="MTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDK
SVFDDGLAFDGSSIRGFQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFTLE
PYSRDPRNIARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRANGSFYEVDAISG
WWNTGAATEADGSPNRGYKVRHKGGYFPVAPNDQYVDLRDKMLTNLINSGFILEKGHH
EVGSGGQAEINYQFNSLLHAADDMQLYKYIIKNTAWQNGKTVTFMPKPLFGDNGSGMH
CHQSLWKDGAPLMYDETGYAGLSDTARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGY
EAPINLVYSQRNRSACVRIPITGSNPKAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIK
NKIEPQAPVDKDLYELPPEEAASIPQTPTQLSDVIDRLEADHEYLTEGGVFTNDLIET
WISFKRENEIEPVNIRPHPYEFALYYDV"
gene complement(2489369..2492353)
/gene="glnE"
/locus_tag="Rv2221c"
CDS complement(2489369..2492353)
/codon_start=1
/transl_table=11
/gene="glnE"
/locus_tag="Rv2221c"
/product="Glutamate-ammonia-ligase adenylyltransferase
GlnE (glutamine-synthetase adenylyltransferase)"
/note="Rv2221c, (MTCY190.32c, MTCY427.02c), len: 994 aa.
glnE, glutamate-ammonia-ligase adenylyltransferase (see
citations below), similar to others e.g. GLNE_ECOLI|P30870
glutamate-ammonia-ligase adenylyltransferase from
Escherichia coli, FASTA score: (24.4% identity in 721 aa
overlap); GLNE_HAEIN|P44419 Glutamate-ammonia-ligase
adenylyltransferase from Haemophilus influenzae (981
aa),FASTA score: (28.1% identity in 199 aa overlap); etc.
Note that initiation codon uncertain."
/db_xref="EnsemblGenomes-Gn:Rv2221c"
/db_xref="EnsemblGenomes-Tr:CCP44999"
/db_xref="GOA:P9WN27"
/db_xref="InterPro:IPR005190"
/db_xref="InterPro:IPR013546"
/db_xref="InterPro:IPR023057"
/db_xref="UniProtKB/Swiss-Prot:P9WN27"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP44999.1"
/translation="MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHV
DLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSVLGSSLALG
DHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLML
AALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPPRLAVIAMG
KCGARELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELV
RTLESHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVE
VQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDAL
AALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAA
HIRPDGRNDAAGVLREELKKQNVRVSKLHTKLFYQPLLESIGPTGLEIAHGMTLEAAG
RRLAALGYEGPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRR
LSEALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKL
LETEPAAVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRAL
TSVWVAVLQAALDVMIRASLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPA
TGVDDARAVKWSTSIAERVRALLGTPSVDPPLELDANLRPEGRNGPLVRTLGSYAAYY
EQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIE
SERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAAD
LVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGE
FLDNYLRVTRRAKAVVRKVFGS"
gene complement(2492402..2493742)
/gene="glnA2"
/locus_tag="Rv2222c"
CDS complement(2492402..2493742)
/codon_start=1
/transl_table=11
/gene="glnA2"
/locus_tag="Rv2222c"
/product="Probable glutamine synthetase GlnA2 (glutamine
synthase) (GS-II)"
/note="Rv2222c, (MTCY427.03c), len: 446 aa. Probable
glnA2,glutamine synthetase class II, similar to others.
Also similar to three other potential glutamine
synthetases in Mycobacterium tuberculosis: Rv2220|glnA1,
Rv2860c|glnA4,and Rv1878|glnA3. Belongs to the glutamine
synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2222c"
/db_xref="EnsemblGenomes-Tr:CCP45000"
/db_xref="GOA:P9WN37"
/db_xref="InterPro:IPR008146"
/db_xref="InterPro:IPR008147"
/db_xref="InterPro:IPR014746"
/db_xref="InterPro:IPR027303"
/db_xref="InterPro:IPR036651"
/db_xref="UniProtKB/Swiss-Prot:P9WN37"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45000.1"
/translation="MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGA
FEEGIGFDGSSIEGFARVSESDTVAHPDPSTFQVLPWATSSGHHHSARMFCDITMPDG
SPSWADPRHVLRRQLTKAGELGFSCYVHPEIEFFLLKPGPEDGSVPVPVDNAGYFDQA
VHDSALNFRRHAIDALEFMGISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYVI
KEVALEEGARASFMPKPFGQHPGSAMHTHMSLFEGDVNAFHSADDPLQLSEVGKSFIA
GILEHACEISAVTNQWVNSYKRLVQGGEAPTAASWGAANRSALVRVPMYTPHKTSSRR
VEVRSPDSACNPYLTFAVLLAAGLRGVEKGYVLGPQAEDNVWDLTPEERRAMGYRELP
SSLDSALRAMEASELVAEALGEHVFDFFLRNKRTEWANYRSHVTPYELRTYLSL"
repeat_region 2493801..2493818
/note="18 bp inverted repeat between 3' end of MTCY427.04c
and 5' end of MTCY427.03c"
gene complement(2493837..2495399)
/locus_tag="Rv2223c"
CDS complement(2493837..2495399)
/codon_start=1
/transl_table=11
/locus_tag="Rv2223c"
/product="Probable exported protease"
/note="Rv2223c, (MTCY427.04c), len: 520 aa. Probable
exported protease ; has signal sequence. Very similar to
three proteases/peptidases from Streptomyces spp.:
L42758,L42759, L27466. FASTA score: L42758|STMSLPD STMSLPD
NID: g940302 - Streptomyces (539 aa) opt: 1032 E(): 0,
(37.5% identity in 533 aa overlap). Also similar to
hypothetical proteins YZZE _ECOLI|P34211 from Escherichia
coli (25.4% identity in 406 aa overlap) and PIR:B36944 in
ompP 3' region (27.5% identity in 218 aa overlap). Highly
similar to Rv2224c and Rv2672 (49.3% identity in 507 aa
overlap); contains PS00120 Lipases, serine active site.
Conserved in M. tuberculosis, M. leprae, M. bovis and M.
avium paratuberculosis; predicted to be essential for in
vivo survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007). Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2223c"
/db_xref="EnsemblGenomes-Tr:CCP45001"
/db_xref="GOA:P9WHR5"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR013595"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WHR5"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45001.1"
/translation="MAAMWRRRPLSSALLSFGLLLGGLPLAAPPLAGATEEPGAGQTP
GAPVVAPQQSWNSCREFIADTSEIRTARCATVSVPVDYDQPGGTQAKLAVIRVPATGQ
RFGALLVNPGGPGASAVDMVAAMAPAIADTDILRHFDLVGFDPRGVGHSTPALRCRTD
AEFDAYRRDPMADYSPAGVTHVEQVYRQLAQDCVDRMGFSFLANIGTASVARDMDMVR
QALGDDQINYLGYSYGTELGTAYLERFGTHVRAMVLDGAIDPAVSPIEESISQMAGFQ
TAFNDYAADCARSPACPLGTDSAQWVNRYHALVDPLVQKPGKTSDPRGLSYADATTGT
INALYSPQRWKYLTSGLLGLQRGSDAGDLLVLADDYDGRDADGHYSNDQDAFNAVRCV
DAPTPADPAAWVAADQRIRQVAPFLSYGQFTGSAPRDLCALWPVPATSTPHPAAPAGA
GKVVVVSTTHDPATPYQSGVDLARQLGAPLITFDGTQHTAVFDGNQCVDSAVMHYFLD
GTLPPTSLRCAP"
gene complement(2495461..2497023)
/gene="caeA"
/locus_tag="Rv2224c"
CDS complement(2495461..2497023)
/codon_start=1
/transl_table=11
/gene="caeA"
/locus_tag="Rv2224c"
/product="Probable carboxylesterase CaeA"
/note="Rv2224c, (MTCY427.05c), len: 520 aa. Probable
caeA,carboxylesterase; has signal sequence and lipoprotein
motif at N-terminal end. Very similar to three
proteases/peptidases from Streptomyces spp.:
L42758,L42759, L27466. FASTA score: L4 2758|STMSLPD
STMSLPD NID: g940302 - Streptomyces (539 aa) opt: 1032
E(): 0, (37.5% identity in 533 aa overlap). Similar to
hypothetical protein SW:YZZE_ECOLI P34211 (27.7% identity
in 412 aa overlap) and highly similar to Rv2224c and
Rv2672 (49.3% identity in 507 aa overlap); contains
PS00013, Prokaryotic membrane lipoprotein lipid attachment
site, and PS00120 Lipases, serine active site. Conserved
in M. tuberculosis,M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007). Predicted to be an outer membrane
protein (See Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv2224c"
/db_xref="EnsemblGenomes-Tr:CCP45002"
/db_xref="GOA:P9WHR3"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:5UGQ"
/db_xref="PDB:5UNO"
/db_xref="PDB:5UOH"
/db_xref="UniProtKB/Swiss-Prot:P9WHR3"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45002.1"
/translation="MGMRLSRRDKIARMLLIWAALAAVALVLVGCIRVVGGRARMAEP
KLGQPVEWTPCRSSNPQVKIPGGALCGKLAVPVDYDRPDGDVAALALIRFPATGDKIG
SLVINPGGPGESGIEAALGVFQTLPKRVHERFDLVGFDPRGVASSRPAIWCNSDADND
RLRAEPQVDYSREGVAHIENETKQFVGRCVDKMGKNFLAHVGTVNVAKDLDAIRAALG
DDKLTYLGYSYGTRIGSAYAEEFPQRVRAMILDGAVDPNADPIEAELRQAKGFQDAFN
NYAADCAKNAGCPLGADPAKAVEVYHSLVDPLVDPDNPRISRPARTKDPRGLSYSDAI
VGTIMALYSPNLWQHLTDGLSELVDNRGDTLLALADMYMRRDSHGRYNNSGDARVAIN
CVDQPPVTDRDKVIDEDRRAREIAPFMSYGKFTGDAPLGTCAFWPVPPTSQPHAVSAP
GLVPTVVVSTTHDPATPYKAGVDLANQLRGSLLTFDGTQHTVVFQGDSCIDEYVTAYL
IGGTTPPSGAKC"
gene 2497742..2498587
/gene="panB"
/locus_tag="Rv2225"
CDS 2497742..2498587
/codon_start=1
/transl_table=11
/gene="panB"
/locus_tag="Rv2225"
/product="3-methyl-2-oxobutanoate hydroxymethyltransferase
PanB"
/note="Rv2225, (MTCY427.06), len: 281 aa.
panB,3-methyl-2-oxobutanoate hydroxymethyltransferase,
similar to PANB_ECOLI|P31057 3-methyl-2-oxobutanoate
hydroxymethyltransferase from Escherichia coli (45.9%
identity in 257 aa overlap). Identified as a substrate for
proteasomal degradation (See Pearce et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv2225"
/db_xref="EnsemblGenomes-Tr:CCP45003"
/db_xref="GOA:P9WIL7"
/db_xref="InterPro:IPR003700"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR040442"
/db_xref="PDB:1OY0"
/db_xref="UniProtKB/Swiss-Prot:P9WIL7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45003.1"
/translation="MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDY
STARIFDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADL
PFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTP
QSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTV
GIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPA
DEHSF"
gene 2498832..2500373
/locus_tag="Rv2226"
CDS 2498832..2500373
/codon_start=1
/transl_table=11
/locus_tag="Rv2226"
/product="Conserved protein"
/note="Rv2226, (MTCY427.07), len: 513 aa. Conserved
protein, similar to hypothetical secreted protein (510 aa)
from Streptomyces coelicolor A3(2) emb|CAB59601.1|
(AL132662) hypothetical secreted protein [Streptomyces
coelicolor. Smith-Waterman scores Expect = 5e-44
Identities = 166/506 (32%)"
/db_xref="EnsemblGenomes-Gn:Rv2226"
/db_xref="EnsemblGenomes-Tr:CCP45004"
/db_xref="GOA:P9WLH9"
/db_xref="InterPro:IPR007899"
/db_xref="InterPro:IPR023577"
/db_xref="InterPro:IPR033469"
/db_xref="InterPro:IPR038186"
/db_xref="UniProtKB/Swiss-Prot:P9WLH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45004.1"
/translation="MPVEAPRPARHLEVERKFDVIESTVSPSFEGIAAVVRVEQSPTQ
QLDAVYFDTPSHDLARNQITLRRRTGGADAGWHLKLPAGPDKRTEMRAPLSASGDAVP
AELLDVVLAIVRDQPVQPVARISTHRESQILYGAGGDALAEFCNDDVTAWSAGAFHAA
GAADNGPAEQQWREWELELVTTDGTADTKLLDRLANRLLDAGAAPAGHGSKLARVLGA
TSPGELPNGPQPPADPVHRAVSEQVEQLLLWDRAVRADAYDAVHQMRVTTRKIRSLLT
DSQESFGLKESAWVIDELRELADVLGVARDAEVLGDRYQRELDALAPELVRGRVRERL
VDGARRRYQTGLRRSLIALRSQRYFRLLDALDALVSERAHATSGEESAPVTIDAAYRR
VRKAAKAAKTAGDQAGDHHRDEALHLIRKRAKRLRYTAAATGADNVSQEAKVIQTLLG
DHQDSVVSREHLIQQAIAANTAGEDTFTYGLLYQQEADLAERCREQLEAALRKLDKAV
RKARD"
gene complement(2500445..2500751)
/gene="rnpB"
misc_RNA complement(2500445..2500751)
/gene="rnpB"
/product="Ribonuclease P RNA"
/note="rnpB, rna component of RNase P."
gene 2500931..2501632
/locus_tag="Rv2227"
CDS 2500931..2501632
/codon_start=1
/transl_table=11
/locus_tag="Rv2227"
/product="Conserved hypothetical protein"
/note="Rv2227, (MTCY427.08), len: 233 aa. Conserved
hypothetical protein, similar to conserved hypothetical
proteins from various bacteria e.g. gb|AAK22693.1|
(AE005746) conserved hypothetical protein from Caulobacter
crescentus (234 aa) Smith-Waterman score = 109 bits
(429),Expect = 1e-41 Identities = 83/167 (49%)"
/db_xref="EnsemblGenomes-Gn:Rv2227"
/db_xref="EnsemblGenomes-Tr:CCP45005"
/db_xref="InterPro:IPR018655"
/db_xref="UniProtKB/Swiss-Prot:P9WLH7"
/protein_id="CCP45005.1"
/translation="MGQTRRLRRLGRHRCRGQRVRWRTATSADHPRRGRPAAQAVRRR
RPVSLDGRYGIQAVRRRAVSIFPCPLSRVIERLKQALYPKLLPIARNWWAKLGREAPW
PDSLDDWLASCHAAGQTRSTALMLKYGTNDWNALHQDLYGELVFPLQVVINLSDPETD
YTGGEFLLVEQRPRAQSRGTAMQLPQGHGYVFTTRDRPVRTSRGWSASPVRHGLSTIR
SGERYAMGLIFHDAA"
gene complement(2501644..2502738)
/locus_tag="Rv2228c"
CDS complement(2501644..2502738)
/codon_start=1
/transl_table=11
/locus_tag="Rv2228c"
/product="Multifunctional protein. Has RNASE
H,alpha-ribazole phosphatase, and acid phosphatase
activities."
/note="Rv2228c, (MTCY427.09c), len: 364 aa.
Multifunctional protein with RNase H, alpha-ribazole
phosphatase, and acid phosphatase activities. Some
similarity to phosphoglycerate mutase and ribonuclease H.
Similar to CAB88177.1|AL352972 putative bifunctional
protein (ribonuclease H/phosphoglycerate mutase) from
Streptomyces coelicolor A3(2) (497 aa); Smith-Waterman
scores: 107 bits (424),Expect = 4e-41 Identities = 160/485
(32%). Also similar in C-terminal part to Rv2419c and
Rv2135c."
/db_xref="EnsemblGenomes-Gn:Rv2228c"
/db_xref="EnsemblGenomes-Tr:CCP45006"
/db_xref="GOA:P9WLH5"
/db_xref="InterPro:IPR002156"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR014636"
/db_xref="InterPro:IPR029033"
/db_xref="InterPro:IPR036397"
/db_xref="PDB:3HST"
/db_xref="UniProtKB/Swiss-Prot:P9WLH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45006.1"
/translation="MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRAT
NNVAEYRGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQAL
ASQFRRINYEWVPRARNTYADRLANDAMDAAAQSAAADADPAKIVATESPTSPGWTGA
RGTPTRLLLLRHGQTELSEQRRYSGRGNPGLNEVGWRQVGAAAGYLARRGGIAAVVSS
PLQRAYDTAVTAARALALDVVVDDDLVETDFGAWEGLTFAEAAERDPELHRRWLQDTS
ITPPGGESFDDVLRRVRRGRDRIIVGYEGATVLVVSHVTPIKMLLRLALDAGSGVLYR
LHLDLASLSIAEFYADGASSVRLVNQTGYL"
gene complement(2502735..2503472)
/locus_tag="Rv2229c"
CDS complement(2502735..2503472)
/codon_start=1
/transl_table=11
/locus_tag="Rv2229c"
/product="Conserved protein"
/note="Rv2229c, (MTCY427.10c), len: 245 aa. Conserved
protein; probable coiled-coil protein similar to conserved
hypothetical proteins in Actinomycetes. Equivalent to
Mycobacterium leprae ML1638 (232 aa), FASTA scores: opt:
868 E(): 4.4e-43; 60.870% identity in 230 aa overlap
emb|CAC30589.1| (AL583922). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv2229c"
/db_xref="EnsemblGenomes-Tr:CCP45007"
/db_xref="GOA:P9WLH3"
/db_xref="InterPro:IPR003743"
/db_xref="UniProtKB/Swiss-Prot:P9WLH3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45007.1"
/translation="MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEH
NAANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHE
LDSLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEID
QARHQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQ
ISAAAEDEVVRCPECGAILLRLEGFEE"
gene complement(2503469..2504608)
/locus_tag="Rv2230c"
CDS complement(2503469..2504608)
/codon_start=1
/transl_table=11
/locus_tag="Rv2230c"
/product="Conserved protein"
/note="Rv2230c, (MTCY427.11c), len: 379 aa. Conserved
protein. Equivalent to Mycobacterium leprae,
ML1639,conserved hypothetical protein (385 aa). Similar to
hypothetical proteins from B. subtilis, P54472, and L.
monocytogenes, P53434. FASTA score: ML1639 (MLCB1243.36)
opt: 2088, E(): 4e-107; 79.481% identity in 385 aa overlap
same as >pir||T44719 hypothetical protein MLCB1243.36
[imported] - Mycobacterium leprae
>gi|3150237|emb|CAA19217.1| (AL023635); P54472|YQFO_BACSU
hypothetical 30. 7 kDa protein in (279 aa) opt: 604; E():
2.2e-30; 38.8% identity in 258 aa overlap.
P53434|YRP2_LISMO hypothetical 41.4 kDa protein (373 aa)
opt: 595, E(): 1e-29; 30.7% identity in 326 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2230c"
/db_xref="EnsemblGenomes-Tr:CCP45008"
/db_xref="GOA:P9WFM1"
/db_xref="InterPro:IPR002678"
/db_xref="InterPro:IPR015867"
/db_xref="InterPro:IPR017221"
/db_xref="InterPro:IPR036069"
/db_xref="UniProtKB/Swiss-Prot:P9WFM1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45008.1"
/translation="MSVRLADVIDVLDQAYPPRLAQSWDSVGLVCGDPDDVVDSVTVA
VDATPAVVDQVPQAGLLLVHHPLLLRGVDTVAANTPKGVLVHRLIRTGRSLFTAHTNA
DSASPGVSDALAHAVGLTVDAVLDPVPGAADLDKWVIYVPRENSEAVRAAVFEAGAGH
IGDYSHCSWSVAGTGQFLAHDGASPAIGSVGTVERVAEDRVEVVAPARARAEVLAAMR
AAHPYEEPAFDIFALVPPPVGSGLGRIGRLPKPEPLRTFVARLEAALPPTATGVRAAG
DPDLLVSRVAVCGGAGDSLLATVAAADVQAYVTADLRHHPADEHCRASQVALIDVAHW
ASEFPWCGQAAEVLRSHFGASLPVRVCTICTDPWNLDHETGRDQA"
gene complement(2504605..2505699)
/gene="cobC"
/locus_tag="Rv2231c"
CDS complement(2504605..2505699)
/codon_start=1
/transl_table=11
/gene="cobC"
/locus_tag="Rv2231c"
/product="Possible aminotransferase CobC"
/note="Rv2231c, (MTCY427.12c), len: 364 aa. Possible
cobC,aminotransferase. Note that initiation codon
uncertain. Similar to CobC aminotransferases e.g.
sp|P21633|COBC_PSEDE COBC protein (333 aa) opt: 277, E():
1.7e-11; 28.8% identity in 313 aa overlap and also to e.g.
SW:HIS8_ECOLI P06986 histidinol-phosphate aminotransferase
(27.0% identity in 289 aa overlap), contains PS00105
aminotransferases class-I pyridoxal-phosphate attachment
site. Real Mycobacterium tuberculosis histidinol-phosphate
aminotransferase, hisC, is Rv1600 (MTCY336.04c)."
/db_xref="EnsemblGenomes-Gn:Rv2231c"
/db_xref="EnsemblGenomes-Tr:CCP45009"
/db_xref="GOA:P9WQ89"
/db_xref="InterPro:IPR004838"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WQ89"
/inference="protein motif:PROSITE:PS00105"
/protein_id="CCP45009.1"
/translation="MLWILGPHTGPLLFDAVASLDTSPLAAARYHGDQDVAPGVLDFA
VNVRHDRPPEWLVRQLAALLPELARYPSTDDVHRAQDAVAERHGRTRDEVLPLVGAAE
GFALLHNLSPVRAAIVVPAFTEPAIALSAAGITAHHVVLKPPFVLDTAHVPDDADLVV
VGNPTNPTSVLHLREQLLELRRPGRILVVDEAFADWVPGEPQSLADDSLPDVLVLRSL
TKTWSLAGLRVGYALGSPDVLARLTVQRAHWPLGTLQLTAIAACCAPRAVAAAAADAV
RLTALRAEMVAGLRSVGAEVVDGAAPFVLFNIADADGLRNYLQSKGIAVRRGDTFVGL
DARYLRAAVRPEWPVLVAAIAEWAKRGGRR"
gene complement(2505736..2506161)
/gene="vapC16"
/locus_tag="Rv2231A"
CDS complement(2505736..2506161)
/codon_start=1
/transl_table=11
/gene="vapC16"
/locus_tag="Rv2231A"
/product="Possible toxin VapC16"
/note="Rv2231A, len: 141 aa. Possible vapC16, toxin, part
of toxin-antitoxin (TA) operon with Rv2231B (See Pandey
and Gerdes, 2005). Nucleotide position 2505919 in the
genome sequence has been corrected, A:G resulting in
A81A."
/db_xref="EnsemblGenomes-Gn:Rv2231A"
/db_xref="EnsemblGenomes-Tr:CCP45010"
/db_xref="GOA:P0CV93"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR041705"
/db_xref="UniProtKB/Swiss-Prot:P0CV93"
/protein_id="CCP45010.1"
/translation="MTMACTACPTIWTLRCQTTCSNAFTGEALPHRHPRLAADAVNET
RAIVQDVRNSILLSAASAWEIAINYRLGKLPPPEPSASYVPDRMRRCGTSPLSVDHAH
TAHRRASGSPSTSIRPCAHRPGTAAWPDDHHRRRPVSCL"
gene complement(2506207..2506383)
/gene="vapB16"
/locus_tag="Rv2231B"
CDS complement(2506207..2506383)
/codon_start=1
/transl_table=11
/gene="vapB16"
/locus_tag="Rv2231B"
/product="Possible antitoxin VapB16"
/note="Rv2231B, len: 58 aa. Possible vapB16,
antitoxin,part of toxin-antitoxin (TA) operon with Rv2231A
(See Pandey and Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2231B"
/db_xref="EnsemblGenomes-Tr:CCP45011"
/db_xref="UniProtKB/Swiss-Prot:P0CW31"
/protein_id="CCP45011.1"
/translation="MALWYQAMIAKFGEQVVDAKVWAPAKRVGVHEAKTRLSELLRLV
YGGQRLRLPAAASR"
gene 2506278..2507153
/gene="ptkA"
/locus_tag="Rv2232"
CDS 2506278..2507153
/codon_start=1
/transl_table=11
/gene="ptkA"
/locus_tag="Rv2232"
/product="Protein tyrosine kinase transcriptional
regulatory protein PtkA"
/note="Rv2232, (MTCY427.13), len: 291 aa. PtkA, protein
tyrosine kinase, similar to members of haloacid
dehalogenase-like family from several bacteria and to
putative phosphatases e.g. Q9I767 and AAK78398. Contains
N-terminal extension. FASTA scores: Q9I767 hypothetical
protein PA0065 (221 aa) opt: 439 E(): 3.2e-18; 38.679%
identity (40.196% ungapped) in 212 aa overlap;
>>tr|AAK78398 Predicted phosphatase, had family (216 aa)
opt: 427, E(): 1.5e-17; 34.762% identity (35.437%
ungapped) in 210 aa overlap. Replaces previous Rv2232 and
Rv2233. Predicted to be an outer membrane protein (See
Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv2232"
/db_xref="EnsemblGenomes-Tr:CCP45012"
/db_xref="GOA:P9WPI9"
/db_xref="InterPro:IPR023198"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="InterPro:IPR041492"
/db_xref="PDB:6F2X"
/db_xref="UniProtKB/Swiss-Prot:P9WPI9"
/protein_id="CCP45012.1"
/translation="MSSPRERRPASQAPRLSRRPPAHQTSRSSPDTTAPTGSGLSNRF
VNDNGIVTDTTASGTNCPPPPRAAARRASSPGESPQLVIFDLDGTLTDSARGIVSSFR
HALNHIGAPVPEGDLATHIVGPPMHETLRAMGLGESAEEAIVAYRADYSARGWAMNSL
FDGIGPLLADLRTAGVRLAVATSKAEPTARRILRHFGIEQHFEVIAGASTDGSRGSKV
DVLAHALAQLRPLPERLVMVGDRSHDVDGAAAHGIDTVVVGWGYGRADFIDKTSTTVV
THAATIDELREALGV"
gene 2507146..2507637
/gene="ptpA"
/gene_synonym="MPtpA"
/locus_tag="Rv2234"
CDS 2507146..2507637
/codon_start=1
/transl_table=11
/gene="ptpA"
/gene_synonym="MPtpA"
/locus_tag="Rv2234"
/product="Phosphotyrosine protein phosphatase PtpA
(protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)"
/note="Rv2234, (MTCY427.15), len: 163 aa. PtpA (alternate
gene name: MPtpA), low molecular weight
protein-tyrosine-phosphatase (see citations below),
similar to other phosphotyrosine protein phosphatases e.g.
P53433|PTPA_STRCO low molecular weight protein-tyrosine
phosphatase from Streptomyces coelicolor (164 aa), FASTA
scores: opt: 455, E(): 3.3e -25, (49.7% identity in 155 aa
overlap); PA1S_HUMAN|P24667 red cell acid phosphatase
1,FASTA score: (37.7% identity in 138 aa overlap); etc.
Contains a phosphatase catalytic site domain located in
N-terminal part. Activity proven biochemically. Supposed a
secreted protein. Substrate of PtkA|Rv2232."
/db_xref="EnsemblGenomes-Gn:Rv2234"
/db_xref="EnsemblGenomes-Tr:CCP45013"
/db_xref="GOA:P9WIA1"
/db_xref="InterPro:IPR017867"
/db_xref="InterPro:IPR023485"
/db_xref="InterPro:IPR036196"
/db_xref="PDB:1U2P"
/db_xref="PDB:1U2Q"
/db_xref="PDB:1ZOJ"
/db_xref="PDB:2LUO"
/db_xref="UniProtKB/Swiss-Prot:P9WIA1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45013.1"
/translation="MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAG
TGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGV
EAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARN
GPS"
gene 2507637..2508452
/locus_tag="Rv2235"
CDS 2507637..2508452
/codon_start=1
/transl_table=11
/locus_tag="Rv2235"
/product="Probable conserved transmembrane protein"
/note="Rv2235, (MTCY427.16), len: 271 aa. Probable
conserved transmembrane protein (see Miller & Shinnick
2001); hydrophobic regions near N- and C-terminus. Similar
to conserved membrane proteins in other Actinomycetes.
Equivalent to Mycobacterium leprae. ML1644 (270 aa). FASTA
scores: opt: 1357, E(): 1.2e-72; 74.170% identity in 271
aa overlap T44717|3150235|CAA19213.1|AL023635
13093419|CAC30595.1|AL583922. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv2235"
/db_xref="EnsemblGenomes-Tr:CCP45014"
/db_xref="GOA:P9WGA7"
/db_xref="InterPro:IPR002994"
/db_xref="UniProtKB/Swiss-Prot:P9WGA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45014.1"
/translation="MPRLAFLLRPGWLALALVVVAFTYLCFTVLAPWQLGKNAKTSRE
NQQIRYSLDTPPVPLKTLLPQQDSSAPDAQWRRVTATGQYLPDVQVLARLRVVEGDQA
FEVLAPFVVDGGPTVLVDRGYVRPQVGSHVPPIPRLPVQTVTITARLRDSEPSVAGKD
PFVRDGFQQVYSINTGQVAALTGVQLAGSYLQLIEDQPGGLGVLGVPHLDPGPFLSYG
IQWISFGILAPIGLGYFAYAEIRARRREKAGSPPPDKPMTVEQKLADRYGRRR"
gene complement(2508434..2509375)
/gene="cobD"
/locus_tag="Rv2236c"
CDS complement(2508434..2509375)
/codon_start=1
/transl_table=11
/gene="cobD"
/locus_tag="Rv2236c"
/product="Probable cobalamin biosynthesis transmembrane
protein CobD"
/note="Rv2236c, (MTCY427.17c), len: 313 aa. Probable
cobD,cobalamin biosynthesis transmembrane protein, similar
to S52223 Rhodobacter capsulatus 945 protein BluD (39.0%
identity in 287 aa overlap) involved in cobinamide
synthesis, and to COBD_PSEDE Pseudomonas dentrificans cobD
protein (37.5% identity in 269 aa overlap), also
CBIB_SALTY Salmonella typhimurum cbiB protein (35.5%
identity in 304 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2236c"
/db_xref="EnsemblGenomes-Tr:CCP45015"
/db_xref="GOA:P9WP93"
/db_xref="InterPro:IPR004485"
/db_xref="UniProtKB/Swiss-Prot:P9WP93"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45015.1"
/translation="MFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQ
ITYRDGRVAGAVHVGLLVGAVGLLGAALQRLPGRSWPVAATATATWAALGGTSLARTG
RQISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAENTADAQVVPLLWA
ASSGVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAARLDDWANYVGARATAVLVVICA
PVVGGSPRGAVRAWRRDAARHPSPNAGVVEAAFAGALDVRLGGPTRYHHELQIRPTLG
DGRSPKVADLRRAVVLSRVVQAGAAVLAVMLVYRRRP"
gene 2509489..2510256
/locus_tag="Rv2237"
CDS 2509489..2510256
/codon_start=1
/transl_table=11
/locus_tag="Rv2237"
/product="Conserved protein"
/note="Rv2237, (MTCY427.18), len: 255 aa. Conserved
protein. Similar to Mycobacterium tuberculosis
hypothetical proteins Rv0276, Rv0826, Rv1645c. FASTA
score: Rv0276 gp|AL021930|MTV035_4 (306 aa) opt: 874, E():
0; 49.6% identity in 282 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2237"
/db_xref="EnsemblGenomes-Tr:CCP45016"
/db_xref="GOA:P9WLH1"
/db_xref="InterPro:IPR018713"
/db_xref="UniProtKB/Swiss-Prot:P9WLH1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45016.1"
/translation="MLLPAANVIMQLAVPGVGYGVLESPVDSGNVYKHPFKRARTTGT
YLAVATIGTESDRALIRGAVDVAHRQVRSTASSPVSYNAFDPKLQLWVAACLYRYFVD
QHEFLYGPLEDATADAVYQDAKRLGTTLQVPEGMWPPDRVAFDEYWKRSLDGLQIDAP
VREHLRGVASVAFLPWPLRAVAGPFNLFATTGFLAPEFRAMMQLEWSQAQQRRFEWLL
SVLRLADRLIPHRAWIFVYQLYLWDMRFRARHGRRIV"
gene complement(2510351..2510587)
/locus_tag="Rv2237A"
CDS complement(2510351..2510587)
/codon_start=1
/transl_table=11
/locus_tag="Rv2237A"
/product="Conserved protein"
/note="Rv2237A, len: 78 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv2237A"
/db_xref="EnsemblGenomes-Tr:CCP45017"
/db_xref="UniProtKB/TrEMBL:I6XDU8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45017.1"
/translation="MLRCRRGAGYGSVVVVGERPGFQSDSAARQTAPPVRPMTSDQLP
ATKADLYAAVDAMRADMRELLEQISTLIREATQK"
gene complement(2510598..2510669)
/gene="valV"
tRNA complement(2510598..2510669)
/gene="valV"
/product="tRNA-Val"
/anticodon=(pos:complement(2510635..2510637),aa:Val,
seq:tac)
/note="codon recognized: GUA; valV, tRNA-Val, anticodon
tac, length = 72"
gene complement(2510715..2511176)
/gene="ahpE"
/locus_tag="Rv2238c"
CDS complement(2510715..2511176)
/codon_start=1
/transl_table=11
/gene="ahpE"
/locus_tag="Rv2238c"
/product="Probable peroxiredoxin AhpE"
/note="Rv2238c, (MTCY427.19c), len: 153 aa. Probable
ahpE,peroxiredoxin. Similarity to many members of AHPC/TSA
family e.g. sp|Q96291|BAS1_ARATH 2-CYS peroxiredoxin BAS1
precursor (265 aa). FASTA score: opt: 275, E(): 2.7e-12;
35.0% identity in 143 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2238c"
/db_xref="EnsemblGenomes-Tr:CCP45018"
/db_xref="GOA:P9WIE3"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR024706"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:1XVW"
/db_xref="PDB:1XXU"
/db_xref="PDB:4X0X"
/db_xref="PDB:4X1U"
/db_xref="PDB:4XIH"
/db_xref="PDB:5C04"
/db_xref="PDB:5ID2"
/db_xref="UniProtKB/Swiss-Prot:P9WIE3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45018.1"
/translation="MLNVGATAPDFTLRDQNQQLVTLRGYRGAKNVLLVFFPLAFTGI
CQGELDQLRDHLPEFENDDSAALAISVGPPPTHKIWATQSGFTFPLLSDFWPHGAVSQ
AYGVFNEQAGIANRGTFVVDRSGIIRFAEMKQPGEVRDQRLWTDALAALTA"
gene complement(2511176..2511652)
/locus_tag="Rv2239c"
CDS complement(2511176..2511652)
/codon_start=1
/transl_table=11
/locus_tag="Rv2239c"
/product="Conserved hypothetical protein"
/note="Rv2239c, (MTCY427.20c), len: 158 aa. Conserved
hypothetical protein, similar to conserved hypothetical
proteins from Mycobacterium leprae (ML1649, 140 aa) and
Streptomyces coelicolor A3(2) (SCC8A.28c, 159 aa).
Equivalent to ML1649 conserved hypothetical protein (140
aa). FASTA scores: ML1649 conserved hypothetical protein
(140 aa) opt: 846, E(): 6.5e-45; 86.429% identity in 140
aa overlap (tr|O69479|O69479 hypothetical 15.2 KDA protein
(140 aa); and opt: 447, E(): 1.2e-21; 50.355% identity
(51.825% ungapped) in 141 aa overlap. Similarity with
ML1649 suggests alternative start at 251198."
/db_xref="EnsemblGenomes-Gn:Rv2239c"
/db_xref="EnsemblGenomes-Tr:CCP45019"
/db_xref="InterPro:IPR021412"
/db_xref="UniProtKB/Swiss-Prot:P9WLG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45019.1"
/translation="MPIATVCTWPAETEGGSTVVAADHASNYARKLGIQRDQLIQEWG
WDEDTDDDIRAAIEEACGGELLDEDTDEVIDVVLLWWRDGDGDLVDTLMDAIGPLAED
GVIWVVTPKTGQPGHVLPAEIAEAAPTAGLMPTSSVNLGNWSASRLVQPKSRAGKR"
gene complement(2511690..2512280)
/locus_tag="Rv2240c"
CDS complement(2511690..2512280)
/codon_start=1
/transl_table=11
/locus_tag="Rv2240c"
/product="Unknown protein"
/note="Rv2240c, (MTCY427.21c), len: 196 aa. Unknown
protein. Start changed since first submission (-69 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2240c"
/db_xref="EnsemblGenomes-Tr:CCP45020"
/db_xref="GOA:P9WLG7"
/db_xref="UniProtKB/Swiss-Prot:P9WLG7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45020.1"
/translation="MLIGWRAVPRRHGGELPRRGALALGCIALLLMGIVGCTTVTDGT
AMPDTNVAPAYRSSVSASVSASAATSSIRESQRQQSLTTKAIRTSCDALAATSKDAID
KVNAYVAAFNQGRNTGPTEGPAIDALNNSASTVSGSLSAALSAQLGDALNAYVDAARA
VANAIGAHASTAEFNRRVDRLNDTKTKALTMCVAAF"
gene 2512539..2515244
/gene="aceE"
/locus_tag="Rv2241"
CDS 2512539..2515244
/codon_start=1
/transl_table=11
/gene="aceE"
/locus_tag="Rv2241"
/product="Pyruvate dehydrogenase E1 component AceE
(pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic
dehydrogenase)"
/note="Rv2241, (MTCY427.22), len: 901 aa. AceE, pyruvate
dehydrogenase E1 component, similar to others e.g.
ODP1_ECOLI|P06958 pyruvate dehydrogenase E1 component from
Escherichia coli, FASTA score: (51.2% identity in 891 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2241"
/db_xref="EnsemblGenomes-Tr:CCP45021"
/db_xref="GOA:P9WIS9"
/db_xref="InterPro:IPR004660"
/db_xref="InterPro:IPR005474"
/db_xref="InterPro:IPR009014"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR035807"
/db_xref="InterPro:IPR041621"
/db_xref="UniProtKB/Swiss-Prot:P9WIS9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45021.1"
/translation="MASYLPDIDPEETSEWLESFDTLLQRCGPSRARYLMLRLLERAG
EQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGV
GGHISTYASSAALYEVGFNHFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQ
LDGFRQEHSHVGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIK
DTSDQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRGNGKII
QELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYV
RDHFFGRDPRTKALVENMSDQDIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKTI
KGYALGKHFEGRNATHQMKKLTLEDLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNA
PEIRYMLDRRRALGGFVPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFK
EVLRDKQIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEV
GQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMA
RGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARM
CGENPENIFFYITVYNEPYVQPPEPENFDPEGVLRGIYRYHAATEQRTNKAQILASGV
AMPAALRAAQMLAAEWDVAADVWSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRA
LENARGPVIAVSDWMRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQ
VVAVLEALAGDGEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPGA"
gene 2515304..2516548
/locus_tag="Rv2242"
CDS 2515304..2516548
/codon_start=1
/transl_table=11
/locus_tag="Rv2242"
/product="Conserved hypothetical protein"
/note="Rv2242, (MTCY427.23), len: 414 aa. Conserved
hypothetical protein. Equivalent to ML1652 conserved
hypothetical protein from Mycobacterium leprae (414
aa),and orthologue in Streptomyces coelicolor A3(2). FASTA
scores: ML1652 opt: 2369, E(): 4.2e-128; 88.406% identity
in 414 aa overlap (AL023635)(AL583922). Some similarity at
3' end with S25203 srmR protein - Streptomyces ambofaciens
(604 aa) opt: 188 E(): 9e-05; (26.4% identity in 277 aa
overlap) and with SW:YAEG_HAEIN P44509 hypothetical
protein HI0093 (42.3% identity in 52 aa overlap). Contains
possible helix-turn-helix motif at aa 360-381 (+3.52 SD)"
/db_xref="EnsemblGenomes-Gn:Rv2242"
/db_xref="EnsemblGenomes-Tr:CCP45022"
/db_xref="InterPro:IPR025736"
/db_xref="InterPro:IPR041522"
/db_xref="InterPro:IPR042070"
/db_xref="UniProtKB/Swiss-Prot:P9WPH5"
/protein_id="CCP45022.1"
/translation="MNDNQLAPVARPRSPLELLDTVPDSLLRRLKQYSGRLATEAVSA
MQERLPFFADLEASQRASVALVVQTAVVNFVEWMHDPHSDVGYTAQAFELVPQDLTRR
IALRQTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAE
ARGTWDSRMEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSD
GDSERASQDVRDTAARHGRAALTDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVV
IGPTAPMLTAAHRSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALHT
DVMRPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQ
PRDAYVLRVAATVGQLNYPTPH"
gene 2516787..2517695
/gene="fabD"
/gene_synonym="mtFabD"
/locus_tag="Rv2243"
CDS 2516787..2517695
/codon_start=1
/transl_table=11
/gene="fabD"
/gene_synonym="mtFabD"
/locus_tag="Rv2243"
/product="Malonyl CoA-acyl carrier protein transacylase
FabD (malonyl CoA:ACPM acyltransferase) (MCT)"
/note="Rv2243, (MTCY427.24), len: 302 aa. FabD (alternate
gene name: mtFabD), malonyl CoA-acyl carrier protein
transacylase (see citations below), highly similar to e.g.
A57356 acyl-CoA carrier protein malonyltransferase from
Streptomyces coelicolor (316 aa), FASTA score: opt:
955,E(): 0, (52.6% identity in 304 aa overlap);
FABD_HAEIN|P43712 malonyl CoA-acyl carrier protein
transacylase from Haemophilus influenzae, FASTA score:
(30.5% identity in 308 aa overlap); and FABD_ECOLI|P25715
from Escherichia coli, FASTA score: (31.4% identity in 309
aa overlap). Identified as a substrate for proteasomal
degradation (See Pearce et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv2243"
/db_xref="EnsemblGenomes-Tr:CCP45023"
/db_xref="GOA:P9WNG5"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR020801"
/db_xref="PDB:2QC3"
/db_xref="PDB:2QJ3"
/db_xref="UniProtKB/Swiss-Prot:P9WNG5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45023.1"
/translation="MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARL
GTTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAGKDVIVAGHSVGEIAAYAIAG
VIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAG
QIVAAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPT
ATLLSNRDGKPVTSAAAAMDTLVSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSG
IAKRELRGVPARAVKSPADLDELANL"
gene complement(2517032..2517134)
/gene="mcr16"
ncRNA complement(2517032..2517134)
/gene="mcr16"
/product="Putative small regulatory RNA"
/note="mcr16, putative small regulatory RNA (See DiChiara
et al., 2010), ends not mapped, ~100 nt band detected by
Northern blot."
/ncRNA_class="other"
gene 2517771..2518118
/gene="acpM"
/locus_tag="Rv2244"
CDS 2517771..2518118
/codon_start=1
/transl_table=11
/gene="acpM"
/locus_tag="Rv2244"
/product="Meromycolate extension acyl carrier protein
AcpM"
/note="Rv2244, (MT2304, MTCY427.25), len: 115 aa.
AcpM,acyl carrier protein, meromycolate precursor
transport,involved in meromycolate extension (see
citations below). Highly similar to others e.g.
L43074|STMFABD2|STMFABD|g870805 acyl carrier protein from
Streptomyces glaucescens (82 aa), FASTA scores: opt:
298,E(): 8.4e-13, (56.6% identity in 76 aa overlap); and
ACP_ECOLI|P02901 acyl carrier protein from Escherichia
coli, FASTA score: (37.3% identity in 67 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2244"
/db_xref="EnsemblGenomes-Tr:CCP45024"
/db_xref="GOA:P9WQF3"
/db_xref="InterPro:IPR003231"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR036736"
/db_xref="PDB:1KLP"
/db_xref="UniProtKB/Swiss-Prot:P9WQF3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45024.1"
/translation="MPVTQEEIIAGIAEIIEEVTGIEPSEITPEKSFVDDLDIDSLSM
VEIAVQTEDKYGVKIPDEDLAGLRTVGDVVAYIQKLEEENPEAAQALRAKIESENPDA
VANVQARLEAESK"
gene 2518115..2519365
/gene="kasA"
/locus_tag="Rv2245"
CDS 2518115..2519365
/codon_start=1
/transl_table=11
/gene="kasA"
/locus_tag="Rv2245"
/product="3-oxoacyl-[acyl-carrier protein] synthase 1 KasA
(beta-ketoacyl-ACP synthase) (KAS I)"
/note="Rv2245, (MTCY427.26), len: 416 aa.
KasA,beta-ketoacyl-ACP synthase, involved in meromycolate
extension (see citations below): belongs to the fas-II
system, which utilizes primarily palmitoyl-ACP rather than
short-chain acyl-ACP primers. Highly similar to others
e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP synthase
from Streptomyces glaucescens (423 aa), FASTA scores: opt:
1105,E(): 0, (44.6% identity in 417 aa overlap);
FABF_ECOLI|P39435 3-oxoacyl-[acyl-carrier-protein]
synthase II from Escherichia coli, FASTA score: (39.4%
identity in 254 aa overlap); FABB_HORVU|P23902
3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score:
(33.4% identity in 413 aa overlap); etc. Strongest
similarity to downstream ORF kasB|Rv2246|MTCY427.27
3-oxoacyl-[acyl-carrier-protein] synthase 2 from
Mycobacterium tuberculosis (438 aa), FASTA score: (66.3%
identity in 409 aa overlap). Belongs to the
beta-ketoacyl-ACP synthases family."
/db_xref="EnsemblGenomes-Gn:Rv2245"
/db_xref="EnsemblGenomes-Tr:CCP45025"
/db_xref="GOA:P9WQD9"
/db_xref="InterPro:IPR000794"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020841"
/db_xref="PDB:2WGD"
/db_xref="PDB:2WGE"
/db_xref="PDB:2WGF"
/db_xref="PDB:2WGG"
/db_xref="PDB:5LD8"
/db_xref="UniProtKB/Swiss-Prot:P9WQD9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45025.1"
/translation="MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIH
ALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPE
VDPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGA
RAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMST
RNDEPERASRPFDKDRDGFVFGEAGALMLIETEEHAKARGAKPLARLLGAGITSDAFH
MVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIGDAAEANAIRVAGCDQA
AVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYG
DYRYAVNNSFGFGGHNVALAFGRY"
gene 2519396..2520712
/gene="kasB"
/locus_tag="Rv2246"
CDS 2519396..2520712
/codon_start=1
/transl_table=11
/gene="kasB"
/locus_tag="Rv2246"
/product="3-oxoacyl-[acyl-carrier protein] synthase 2 KasB
(beta-ketoacyl-ACP synthase) (KAS I)"
/note="Rv2246, (MTCY427.27), len: 438 aa.
KasB,beta-ketoacyl-ACP synthase, involved in meromycolate
extension (see citations below). Highly similar or similar
to others e.g. L43074|STMFABD3|g870805 beta-ketoacyl-ACP
synthase from Streptomyces glaucescens (423 aa), FASTA
scores: opt: 1091, E(): 0, (44.7% identity in 416 aa
overlap); FABF_ECOLI|P39435
3-oxoacyl-[acyl-carrier-protein] synthase II from
Escherichia coli, FASTA score: (37.0% identity in 411 aa
overlap); FABB_HORVU|P23902
3-oxoacyl-[acyl-carrier-protein] synthase I, FASTA score:
(32.5% identity in 415 aa overlap); etc. Strongest
similarity to upstream ORF Rv2245|kasA|MTCY427.26
3-oxoacyl-[acyl-carrier-protein] synthase 1 from
Mycobacterium tuberculosis (416 aa), FASTA score: (66.3%
identity in 409 aa overlap). Belongs to the
beta-ketoacyl-ACP synthases family."
/db_xref="EnsemblGenomes-Gn:Rv2246"
/db_xref="EnsemblGenomes-Tr:CCP45026"
/db_xref="GOA:P9WQD7"
/db_xref="InterPro:IPR000794"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020841"
/db_xref="PDB:2GP6"
/db_xref="UniProtKB/Swiss-Prot:P9WQD7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45026.1"
/translation="MGVPPLAGASRTDMEGTFARPMTELVTGKAFPYVVVTGIAMTTA
LATDAETTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDHQLTRIELRRMGY
LQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTGLGSAEELVFSYDDMRARGMKAVSPL
TVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAIARAWQQIVLGEADAAICGGV
ETRIEAVPIAGFAQMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLIETEEHAK
ARGANILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAGLAPGDIDHVNAHAT
GTQVGDLAEGRAINNALGGNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPT
LNLVNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY"
gene 2520743..2522164
/gene="accD6"
/locus_tag="Rv2247"
CDS 2520743..2522164
/codon_start=1
/transl_table=11
/gene="accD6"
/locus_tag="Rv2247"
/product="Acetyl/propionyl-CoA carboxylase (beta subunit)
AccD6"
/note="Rv2247, (MTCY427.28), len: 473 aa.
AccD6,Acetyl/Propionyl CoA Carboxylase, beta subunit (see
citations below), highly similar to e.g. PCCB_RHOSO|Q06101
propionyl-CoA carboxylase beta chain, FASTA score: (75.1%
identity in 437 aa overlap). Similar to many other
Acetyl/Propionyl CoA Carboxylases from Mycobacterium
tuberculosis. Belongs to the AccD / PccB family."
/db_xref="EnsemblGenomes-Gn:Rv2247"
/db_xref="EnsemblGenomes-Tr:CCP45027"
/db_xref="GOA:P9WQH5"
/db_xref="InterPro:IPR011762"
/db_xref="InterPro:IPR011763"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR034733"
/db_xref="PDB:4L6W"
/db_xref="UniProtKB/Swiss-Prot:P9WQH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45027.1"
/translation="MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLA
AAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLA
EGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHF
DRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRL
SGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEW
GGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVM
GAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHT
RSKLTEALAQAPARRGRHKNIPL"
repeat_region 2522173..2522230
/note="58 bp inverted repeat near 3'end of MTCY427.28"
gene 2522360..2523175
/locus_tag="Rv2248"
CDS 2522360..2523175
/codon_start=1
/transl_table=11
/locus_tag="Rv2248"
/product="Conserved hypothetical protein"
/note="Rv2248, (MTCY427.29), len: 271 aa. Conserved
hypothetical protein. Very similar to hypothetical M.
tuberculosis proteins Rv3517, Rv1482c, Rv3555c,
Rv3714c,Rv1073. FASTA score: MTCY06G11.02c MTCY6G11 NID:
g1877284 -(289 aa) opt: 366 E(): 5.3e-18; (32.1% identity
in 249 aa overlap). Some similarity to Mycobacterium avium
protein AF002133|AF0021 339 AF002133 NID: g2183254 (346
aa) opt: 308 E(): 5.2e-14; (28.3% identity in 254 aa
overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2248"
/db_xref="EnsemblGenomes-Tr:CCP45028"
/db_xref="GOA:P9WLG5"
/db_xref="InterPro:IPR011335"
/db_xref="UniProtKB/Swiss-Prot:P9WLG5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45028.1"
/translation="MTRQQLDVQVKNGGLVRVWYGVYAAQEPDLLGRLAALDVFMGGH
AVACLGTAAALYGFDTENTVAIHMLDPGVRMRPTVGLMVHQRVGARLQRVSGRLATAP
AWTAVEVARQLRRPRALATLDAALRSMRCARSEIENAVAEQRGRRGIVAARELLPFAD
GRAESAMESEARLVMIDHGLPLPELQYPIHGHGGEMWRVDFAWPDMRLAAEYESIEWH
AGPAEMLRDKTRWAKLQELGWTIVPIVVDDVRREPGRLAARIARHLDRARMAG"
repeat_region 2523184..2523236
/note="53 bp inverted repeat between 3' ends of MTCY427.29
and MT CY427.31c"
gene complement(2523241..2524791)
/gene="glpD1"
/locus_tag="Rv2249c"
CDS complement(2523241..2524791)
/codon_start=1
/transl_table=11
/gene="glpD1"
/locus_tag="Rv2249c"
/product="Probable glycerol-3-phosphate dehydrogenase
GlpD1"
/note="Rv2249c, (MTCY427.31c), len: 516 aa. Probable
glpD1,glycerol-3-phosphate dehydrogenase, similar to
SW:GLPD_ECOLI P13035 aerobic glycerol-3-phosphate
dehydrogenase (30.0% identity in 486 aa overlap) and
SW:GLPA_ECOLI P13032 anaerobic glycerol-3-phosphate
dehydrogenase (28.2% identity in 504 aa overlap). Also
similar to Rv3302c|glpD2 glycerol-3-phosphate
dehydrogenase. Cofactor: FAD (by similarity). Belongs to
the FAD-dependent glycerol-3-phosphate dehydrogenase
family."
/db_xref="EnsemblGenomes-Gn:Rv2249c"
/db_xref="EnsemblGenomes-Tr:CCP45029"
/db_xref="GOA:P9WN81"
/db_xref="InterPro:IPR000447"
/db_xref="InterPro:IPR006076"
/db_xref="InterPro:IPR031656"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR038299"
/db_xref="UniProtKB/Swiss-Prot:P9WN81"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45029.1"
/translation="MLMPHSAALNAARRSADLTALADGGALDVIVIGGGITGVGIALD
AATRGLTVALVEKHDLAFGTSRWSSKLVHGGLRYLASGNVGIARRSAVERGILMTRNA
PHLVHAMPQLVPLLPSMGHTKRALVRAGFLAGDALRVLAGTPAATLPRSRRIPASRVV
EIAPTVRRDGLDGGLLAYDGQLIDDARLVMAVARTAAQHGARILTYVGASNVTGTSVE
LTDRRTRQSFALSARAVINAAGVWAGEIDPSLRLRPSRGTHLVFDAKSFANPTAALTI
PIPGELNRFVFAMPEQLGRIYLGLTDEDAPGPIPDVPQPSSEEITFLLDTVNTALGTA
VGTKDVIGAYAGLRPLIDTGGAGVQGRTADVSRDHAVFESPSGVISVVGGKLTEYRYM
AEDVLNRAITLRHLRAAKCRTRNLPLIGAPANPGPAPGSGAGLPESLVARYGAEAANV
AAAATCERPTEPVADGIDVTRAEFEYAVTHEGALDVDDILDRRTRIGLVPRDRERVVA
VAKEFLSR"
gene complement(2524785..2525354)
/locus_tag="Rv2250c"
CDS complement(2524785..2525354)
/codon_start=1
/transl_table=11
/locus_tag="Rv2250c"
/product="Possible transcriptional regulatory protein"
/note="Rv2250c, (MTCY427.32c), len: 189 aa. Possible
transcriptional regulatory protein, TetR family. Start
unclear; ORF has been shortened since first submission to
avoid overlap with Rv2251 (-30 aa). Contains probable
helix-turn-helix motif (Score 2243, +6.70 SD)"
/db_xref="EnsemblGenomes-Gn:Rv2250c"
/db_xref="EnsemblGenomes-Tr:CCP45030"
/db_xref="GOA:P9WMC5"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/Swiss-Prot:P9WMC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45030.1"
/translation="MLSMSNDRADTGGRILRAAASCVVDYGVDRVTLAEIARRAGVSR
PTVYRRWPDTRSIMASMLTSHIADVLREVPLDGDDREALVKQIVAVADRLRGDDLIMS
VMHSELARVYITERLGTSQQVLIEGLAARLTVAQRSGSVRSGDARRLATMVLLIAQST
IQSADIVDSILDSAALATELTHALNGYLC"
gene 2525402..2525821
/locus_tag="Rv2250A"
CDS 2525402..2525821
/codon_start=1
/transl_table=11
/locus_tag="Rv2250A"
/product="Possible flavoprotein"
/note="Rv2250A, len: 139 aa. Conserved hypothetical
protein, possibly flavoprotein. Similar to N-terminus of
SCF91.28c|AL132973_28 possible flavoprotein from
Streptomyces coelicolor (530 aa), FASTA scores: opt:
240,E(): 1.1e-07, (39.25% identity in 107 aa overlap).
Possible frameshift between nt 2525723 to 2525727. The
sequences of CDC 1551 and Mycobacterium bovis are missing
a single G base."
/db_xref="EnsemblGenomes-Gn:Rv2250A"
/db_xref="EnsemblGenomes-Tr:CCP45031"
/db_xref="InterPro:IPR016167"
/db_xref="UniProtKB/TrEMBL:L0TBY6"
/protein_id="CCP45031.1"
/translation="MKWDAWGDPAAAKPLSDGVRSLLKQVVGLADSEQPELDPAQVQL
RPSALSGADHDALARIVGTEYFRTADRDRLLHAGGKSTPDLLRRKDTGVQDAPDAVLL
PGGPNGGGRRRRHLALLLRPRHCRGPVWWRHQRRWWA"
gene 2525565..2526992
/locus_tag="Rv2251"
CDS 2525565..2526992
/codon_start=1
/transl_table=11
/locus_tag="Rv2251"
/product="Possible flavoprotein"
/note="Rv2251, (MTV022.01), len: 475 aa. Possible
flavoprotein, probably continuation of Rv2250A, similar to
MTCY164.18 from Mycobacterium tuberculosis and to several
alkyldihydroxyacetonephosphate synthases (e.g. O00116).
Also some similarity to D-lactate dehydrogenases. FASTA
scores: sptr|O05784|O05784 hypothetical 56.5 kDa protein.
(527 aa) opt: 1019 E(): 0; (38.6% identity in 487 aa
overlap) and sp|O00116|ADAS_HUMAN alkyldihydroxyaceton
ephosphate synthase precursor (658 aa) opt: 558 E():
6.2e-27; (31.3% identity in 447 aa overlap). Predicted to
be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2251"
/db_xref="EnsemblGenomes-Tr:CCP45032"
/db_xref="GOA:L0TBR2"
/db_xref="InterPro:IPR004113"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016164"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016171"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:L0TBR2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45032.1"
/translation="MRWRASSAPSISAPPIATGCCTPAASPPQTCCGAKTPVSRMRPT
RCCCPAAPTGEDAVADILHYCSDHGIAVVPFGGGTSVVGGLDPVRNDFRAVISLDMRR
FDRLHRIDEVSGEAELEAGVTGPEAERLLGEHGFSLGHFPQSFEFATIGGFAATRSSG
QDSAGYGRFNDMILGLRMITPVGVLDLGRVPASAAGPDLRQLAIGSEGVFGVITRVRL
RVHRIPESTRYEAWSFPDFATGVAALRTITQTGTGPTVVRLSDEAETGVNLATTEAIG
ETQITGGCLGITVFEGTQEHTESRHAETRALLAARGGTSLGEGPARAWERGRFAAPYL
RDSLLAAGALCETLETATVWSNTPVLKAAVTEALTTSLAASGTPALVMCHVSHVYPTG
ASLYFTVVAGQRGDPIEQWLAAKKAASDAIMATGGTITHHHAVGSDHRPWMRAEVGDL
GVTLLRTIKATLDPAGILNPGKLIP"
gene 2526989..2527918
/locus_tag="Rv2252"
CDS 2526989..2527918
/codon_start=1
/transl_table=11
/locus_tag="Rv2252"
/product="Diacylglycerol kinase"
/note="Rv2252, (MTV022.02), len: 309 aa. Diacylglycerol
kinase (See Owens et al., 2006), similar to hypothetical
proteins from Bacillus subtilis (e.g.
BSUB0004_120),Streptomyces coelicolor A3(2)
>emb|CAB61184.1| (AL132973) hypothetical protein SCF91.27c
(293 aa) and P39074. FASTA scores: Z99107|BSUB0004_120
Bacillus subtilis complete genome (303 aa) opt: 397, E():
1.7e-19; (26.4% identity in 299 aa overlap) and P390
74|BMRU_BACSU BMRU protein (297 aa) opt: 309, E():
1.3e-13; (25.0% identity in 284 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2252"
/db_xref="EnsemblGenomes-Tr:CCP45033"
/db_xref="GOA:P9WP29"
/db_xref="InterPro:IPR001206"
/db_xref="InterPro:IPR005218"
/db_xref="InterPro:IPR016064"
/db_xref="InterPro:IPR017438"
/db_xref="UniProtKB/Swiss-Prot:P9WP29"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45033.1"
/translation="MSAGQLRRHEIGKVTALTNPLSGHGAAVKAAHGAIARLKHRGVD
VVEIVGGDAHDARHLLAAAVAKGTDAVMVTGGDGVVSNALQVLAGTDIPLGIIPAGTG
NDHAREFGLPTKNPKAAADIVVDGWTETIDLGRIQDDNGIEKWFGTVAATGFDSLVND
RANRMRWPHGRMRYYIAMLAELSRLRPLPFRLVLDGTEEIVADLTLADFGNTRSYGGG
LLICPNADHSDGLLDITMAQSDSRTKLLRLFPTIFKGAHVELDEVSTTRAKTVHVECP
GINVYADGDFACPLPAEISAVPAALQVLRPRHG"
gene 2527984..2528487
/locus_tag="Rv2253"
CDS 2527984..2528487
/codon_start=1
/transl_table=11
/locus_tag="Rv2253"
/product="Possible secreted unknown protein"
/note="Rv2253, (MTV022.03), len: 167 aa. Possible secreted
protein; has potential N-terminal signal peptide.
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2253"
/db_xref="EnsemblGenomes-Tr:CCP45034"
/db_xref="GOA:O53527"
/db_xref="UniProtKB/TrEMBL:O53527"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45034.1"
/translation="MSGHRKKAMLALAAASLAATLAPNAVAAAEPSWNGQYLVTLSAN
AKTGTSMAANRPEYPHKANYTFSSRCASDVCIATVVDAPPPKNEFIPRPIEYTWNGTQ
WVREISWQWDCLLPDGTIEYAPAKSITAYTPGQYGILTGVFHTDIASGTCKGNVDMPV
SAKPIVG"
gene complement(2528520..2528975)
/locus_tag="Rv2254c"
CDS complement(2528520..2528975)
/codon_start=1
/transl_table=11
/locus_tag="Rv2254c"
/product="Probable integral membrane protein"
/note="Rv2254c, (MTV022.04c), len: 151 aa. Probable
integral membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv2254c"
/db_xref="EnsemblGenomes-Tr:CCP45035"
/db_xref="GOA:O53528"
/db_xref="InterPro:IPR001123"
/db_xref="UniProtKB/TrEMBL:O53528"
/protein_id="CCP45035.1"
/translation="MRYRDLETVAAPTINVLRVWPEIVGAIVLLVIAAMGIGHGLRPS
PEPVPAPQKQLGCVRFALIFGLTAINPATFVYFTAVAVTLARALRATTAIAVVVGVAL
ASLLWQLLLVSAGAFLRSRATARVRRMTVLAGNAVIAAFGAVLVVHAFA"
gene complement(2528980..2529174)
/locus_tag="Rv2255c"
CDS complement(2528980..2529174)
/codon_start=1
/transl_table=11
/locus_tag="Rv2255c"
/product="Hypothetical protein"
/note="Rv2255c, (MTV022.05c), len: 64 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2255c"
/db_xref="EnsemblGenomes-Tr:CCP45036"
/db_xref="UniProtKB/TrEMBL:O53529"
/protein_id="CCP45036.1"
/translation="MDGIVDRGVRARPCQKVVAVLRRSKSHIDKRLDAATGNAFLGKQ
VLSAAGVVEYRPPRRSPLST"
gene complement(2529341..2529874)
/locus_tag="Rv2256c"
CDS complement(2529341..2529874)
/codon_start=1
/transl_table=11
/locus_tag="Rv2256c"
/product="Conserved hypothetical protein"
/note="Rv2256c, (MTV022.06c), len: 177 aa. Conserved
hypothetical protein, similar to Streptomyces glaucescens
ORF5 (164 aa) and Streptomyces coelicolor hypothetical
protein SC4A7.19c (164 aa; emb|CAB62723.1|AL133423). FASTA
scores: sptr|Q54209|Q54209 FABD, FABH, FABC, FABB, and
ORF5 (164 aa) opt: 504, E(): 3.9e-27; (44.4% identity in
162 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2256c"
/db_xref="EnsemblGenomes-Tr:CCP45037"
/db_xref="InterPro:IPR021491"
/db_xref="UniProtKB/TrEMBL:O53530"
/protein_id="CCP45037.1"
/translation="MEPKEQQMRASNQFADVTSGVVYIHASPAAVCPHVEWALSSTLQ
AKANLVWTPQPALPPQLRAVTNWVGPVGTGARLANALRSWSVLRFEVTEDPSPGVDGQ
RFSHTPQLGLWSGAMSANGDIMVGEMRLRAMMAQGADTLAAELDSVLGTAWDQALEVY
RDGGDAGEVTWLSRGVG"
gene complement(2530004..2530822)
/locus_tag="Rv2257c"
CDS complement(2530004..2530822)
/codon_start=1
/transl_table=11
/locus_tag="Rv2257c"
/product="Conserved protein"
/note="Rv2257c, (MTV022.07c), len: 272 aa. Conserved
protein, similar to hypothetical protein SC4A7.08 from
Streptomyces coelicolor (273 aa; 58% identity in 243 aa
overlap). Also similar to several putative esterases and
penicillin-binding proteins in M. tuberculosis e.g.
Rv1923,Rv1497, Rv2463, Rv3775, Rv1922, Rv1730c."
/db_xref="EnsemblGenomes-Gn:Rv2257c"
/db_xref="EnsemblGenomes-Tr:CCP45038"
/db_xref="GOA:O53531"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:O53531"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45038.1"
/translation="MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKP
LVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYSNY
GFTVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGATSTVADLAVFA
GDLLRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGEC
NSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT"
gene complement(2530836..2531897)
/locus_tag="Rv2258c"
CDS complement(2530836..2531897)
/codon_start=1
/transl_table=11
/locus_tag="Rv2258c"
/product="Possible transcriptional regulatory protein"
/note="Rv2258c, (MTV022.08c), len: 353 aa. Possible
transcriptional regulatory protein, similar to several
hypothetical proteins from C. elegans. FASTA scores:
sptr|O01593|O01593 coded for by C. elegans CDNA YK102 F
(365 aa) opt: 577, E(): 6.4e-31; (30.5% identity in 341 aa
overlap). Contains possible helix-turn helix motif at aa
47-68 (+3.65 SD)"
/db_xref="EnsemblGenomes-Gn:Rv2258c"
/db_xref="EnsemblGenomes-Tr:CCP45039"
/db_xref="GOA:O53532"
/db_xref="InterPro:IPR025714"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:5F8C"
/db_xref="PDB:5F8E"
/db_xref="PDB:5F8F"
/db_xref="UniProtKB/TrEMBL:O53532"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45039.1"
/translation="MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLP
PATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDN
LAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLP
LVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARL
GLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDI
KASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTD
VTVAEIESDVLNNYYIARK"
repeat_region complement(2531898..2531950)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(2531951..2532003)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(2532004..2532056)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(2532057..2532109)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(2532110..2532162)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(2532163..2532212)
/note="50 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 2532245..2533330
/gene="mscR"
/locus_tag="Rv2259"
CDS 2532245..2533330
/codon_start=1
/transl_table=11
/gene="mscR"
/locus_tag="Rv2259"
/product="S-nitrosomycothiol reductase MscR"
/note="Rv2259, (MTV022.09), len: 361 aa.
MscR,S-nitrosomycothiol reductase (see Vogt et al.,
2003),similar to several zinc-containing alcohol
dehydrogenases especially from Amycolatopsis methanolica
P80094 (360 aa),FASTA scores: sp|P80094|FADH_AMYME
NAD/mycothiol-dependent formaldehyde dehydrogenase
(MD-FALDH) Length = 360, Expect = e-156, Identities =
268/358 (74%). Also similar to Rv0162c, (MTCI28.02c, 35.0%
identity in 371 aa overlap). Contains PS00059
Zinc-containing alcohol dehydrogenases signature. Note
previously known as adhE2"
/db_xref="EnsemblGenomes-Gn:Rv2259"
/db_xref="EnsemblGenomes-Tr:CCP45040"
/db_xref="GOA:O53533"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR017816"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53533"
/inference="protein motif:PROSITE:PS00059"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45040.1"
/translation="MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVVDVTACGVCHT
DLTYREGGINDEYPFLLGHEAAGIIEAVGPGVTAVEPGDFVILNWRAVCGQCRACKRG
RPRYCFDTFNAEQKMTLTDGTELTAALGIGAFADKTLVHSGQCTKVDPAADPAVAGLL
GCGVMAGLGAAINTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLD
WARTFGATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPETYQQAFYARDLAGTVV
LVGVPTPDMRLDMPLVDFFSHGGALKSSWYGDCLPESDFPTLIDLYLQGRLPLQRFVS
ERIGLEDVEEAFHKMHGGKVLRSVVML"
gene 2533330..2533965
/locus_tag="Rv2260"
CDS 2533330..2533965
/codon_start=1
/transl_table=11
/locus_tag="Rv2260"
/product="Conserved hypothetical protein"
/note="Rv2260, (MTV022.10), len: 211 aa. Conserved
hypothetical protein, similar to hypothetical proteins
Rv0634c, Rv1637c, Rv3677c, Rv2581c from Mycobacterium
tuberculosis and to various hydrolases. FASTA scores:
sptr|O06154|O06154 hypothetical 21.3 kDa protein (200 aa)
opt: 355, E(): 4e- 15; (37.4% identity in 198 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2260"
/db_xref="EnsemblGenomes-Tr:CCP45041"
/db_xref="GOA:O53534"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:O53534"
/protein_id="CCP45041.1"
/translation="MAAIERVITHGTFELDGGSWEVDNNIWLVGDDSEVVVFDAAHHA
APIIDAVGGRKVVAVICTHGHNDHVTVAPELGTALDAPVLMHPGDAVLWRMTHPDKSF
RAVSDGDAVRVGGTELRALHTPGHSPGSVCWYAPELGPGTGTVFSGDTLFAGGPGATG
RSYSDFPTILRSISGRLGALPGDTVVHTGHGDSTTIGDEIVHYEEWVARGH"
gene complement(2534042..2534464)
/locus_tag="Rv2261c"
CDS complement(2534042..2534464)
/codon_start=1
/transl_table=11
/locus_tag="Rv2261c"
/product="Conserved hypothetical protein"
/note="Rv2261c, (MTV022.11c), len: 140 aa. Conserved
hypothetical protein, with function unknown but some
similarity to C-terminal end of PCC6803 apolipoprotein
N-acyltransferase from Synechocystis sp. Note that next
ORF shows similarity to N-terminal part of P74055
apolipoprotein N-acyltransferase from Escherichia coli
(519 aa), FASTA scores: opt: 142, E(): 0.007, (29.9%
identity in 117 aa overlap), suggesting possible
frameshift. Sequence of clones from two sources has been
checked but no error found."
/db_xref="EnsemblGenomes-Gn:Rv2261c"
/db_xref="EnsemblGenomes-Tr:CCP45042"
/db_xref="GOA:I6XDW5"
/db_xref="InterPro:IPR003010"
/db_xref="InterPro:IPR036526"
/db_xref="UniProtKB/TrEMBL:I6XDW5"
/protein_id="CCP45042.1"
/translation="MHIAPLISYEMTFSDLTRHAARLGAALLVYQSSTSTFQGSWAQP
QLAAQPAVRAVEAGIPAVHASLSGDSSAFDTRGRRLAWCSAEFNGAIVVNVPLASNVT
LYLRLGDWVPVTAFVVMGAGFAVFLRRSLARVSDCADK"
gene complement(2534470..2535552)
/locus_tag="Rv2262c"
CDS complement(2534470..2535552)
/codon_start=1
/transl_table=11
/locus_tag="Rv2262c"
/product="Conserved hypothetical protein"
/note="Rv2262c, (MTV022.12c), len: 360 aa. Conserved
hypothetical protein, with function unknown but some
similarity to N-terminal 70% of
P23930|P77703|LNT_ECOLI|cute|B0657 apolipoprotein
N-acyltransferase from Escherichia coli strain K12 (512
aa), FASTA scores: opt: 239, E(): 1.6e-07, (30.4% identity
in 359 aa overlap). Note that neighboring ORF shows
similarity to N -terminal part of PCC6803 apolipoprotein
N-acyltransferase from Synechocystis sp., suggesting
possibility of frameshift. Sequence of clones from two
sources has been checked but no error found. Appear to be
two extra bases at position 1876970 compared to CDC1551
strain."
/db_xref="EnsemblGenomes-Gn:Rv2262c"
/db_xref="EnsemblGenomes-Tr:CCP45043"
/db_xref="GOA:O53536"
/db_xref="InterPro:IPR003010"
/db_xref="InterPro:IPR004563"
/db_xref="InterPro:IPR036526"
/db_xref="UniProtKB/TrEMBL:O53536"
/protein_id="CCP45043.1"
/translation="MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVP
LLLVVRAAPTSWEGALRAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWLPAGWL
AHRLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGGPWALLGASQWSQPVTLASA
SLGGVWLTSFLLVATNTAIASVLVCRATGGRLVALGCVIGCAGLGPASYLLGSVPVGG
PTVRVALVQAGDIADAAARLAAGEEFTAAVADQRPDLVVWGESSVGQDLTRHPDVLAR
LAELSQRVGADLLVNVDAPAPDGGIYKSAVLVGAHEAVGSYRKTRLVPFGEYVLRCAR
FSAGSPATARPPQRIGSAAPGRWCWR"
gene 2535641..2536594
/locus_tag="Rv2263"
CDS 2535641..2536594
/codon_start=1
/transl_table=11
/locus_tag="Rv2263"
/product="Possible oxidoreductase"
/note="Rv2263, (MTV022.13), len: 317 aa. Possible
oxidoreductase, similar to several oxidoreductases.
Similarity suggests alternative GTG start at 10154 but
then no rbs. FASTA scores: sptr|Q544 05|Q54405 probably an
NADP-dependent oxidoreductase (297 aa) opt: 487, E():
1.1e-23; (36.1% identity in 299 aa overlap). Also similar
to Mycobacterium tuberculosis Rv0068, and Rv0439c."
/db_xref="EnsemblGenomes-Gn:Rv2263"
/db_xref="EnsemblGenomes-Tr:CCP45044"
/db_xref="GOA:O53537"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53537"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45044.1"
/translation="MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMA
IRNRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADGRPIDLLINNAG
VMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQRARVVSLSSLAARRGRIH
FDDLQFERSYAPMTAYGQSKLAVLMFARELDRRSRAAGWGIISNAAHPGLTKTNLQIA
GPSHGRDKPALMERLYKTSWRFAPFLWQEIEEGILPALYAAATPQADGGAFYGPRGRY
EVAGGGVREAKVPAAARNDADSKRLWEVSEQLTGVSYPKSR"
gene complement(2536572..2538350)
/locus_tag="Rv2264c"
CDS complement(2536572..2538350)
/codon_start=1
/transl_table=11
/locus_tag="Rv2264c"
/product="Conserved hypothetical proline rich protein"
/note="Rv2264c, (MTV022.14c), len: 592 aa. Conserved
hypothetical Pro-rich protein, similar to hypothetical
proteins Rv0312 (MTCY63.17, 620 aa and Rv0350) that has
highly Pro-, Thr-rich C-terminus. Contains PS00343
Gram-positive cocci surface proteins 'anchoring'
hexapeptide. FASTA scores: Z96800|MTCY63_17 Mycobacterium
tuberculosis cosmid (620 aa) opt: 1075, E(): 8.8e-24;
(38.9% identity in 627 aa overlap). Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2264c"
/db_xref="EnsemblGenomes-Tr:CCP45045"
/db_xref="GOA:O53538"
/db_xref="InterPro:IPR004753"
/db_xref="InterPro:IPR013126"
/db_xref="UniProtKB/TrEMBL:O53538"
/inference="protein motif:PROSITE:PS00343"
/protein_id="CCP45045.1"
/translation="MATGARPALGLSIGVTNLAAVAADHSITRKPVLTLYRQRPPEVG
VPSENPRLDEPGLVITDFVDRVGDSVGIVAADGSVYRSEALVADALLALAYTATGGRA
LPGSVTVTYPAHWGPAAVAALDSALRRASEWSHGTSSTAQPLSLLPDAAAALYAIRAD
PGIPARGIVAVCDFGGSGTGITLVDAADEYRPVAATVRHQAFSGDLIDQSLLSYVMSE
LPGTGAFDPAGTSAIGSLTKLRIECRKAKERLSSSTVTTLTDALGGDIRLTRNELEDT
IRDSLDSVGRALEQTLARSGIRTAELVAIVSVGGGANIPAVTTTLSGRFCVPVVRTPR
PQLTAAFGGALWAARRPGDTSATVLTAVTSATATAPADAPASVLQPALAWSEADEDSH
IGPAPGYTAARPSLSFDHDAHAEPEPKSPPIPWYRLPAVIITGTTVAVLLVGAAVAIG
LSTGDQPTAPGTPQRPGVTTTAAPPPSPAPASDGPTTEPAPPVQAPATGGPAPPLQQP
LPPPPTTTNTQPAVTTDVITPAPTTPASAPPATTQPPATTQPPATTSPSPPPIPPIPP
IPEIPQLPPGIPQVPGIGQFSAISGS"
gene 2538700..2539929
/locus_tag="Rv2265"
CDS 2538700..2539929
/codon_start=1
/transl_table=11
/locus_tag="Rv2265"
/product="Possible conserved integral membrane protein"
/note="Rv2265, (MTCY339.45c), len: 409 aa. Possible
conserved integral membrane protein, with some similarity
to others e.g. M. thermoauto. sp|O26855|O26855 conserved
protein (383 aa), FASTA score: opt: 898 z-score: 1023.5
E(): 0; 38.0% identity in 384 aa overlap; Q58713
hypothetical 44.1 kDa protein 1 317 (398 aa), FASTA
scores,opt: 305 E(): 1.2e-11; 22.8% identity in 382 aa
overlap; also KGTP_ECOLI P17448 alpha-ketoglutarate
permease (432 aa), FASTA scores, opt: 156, E(): 0.006,
(24.8% identity in 416 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2265"
/db_xref="EnsemblGenomes-Tr:CCP45046"
/db_xref="GOA:P9WLG3"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WLG3"
/protein_id="CCP45046.1"
/translation="MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARS
ITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVT
VPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVG
AMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLG
NPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMA
ADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQE
STLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTLVVVVIALEL
MALVMMFAIRLPRVAPS"
gene 2540104..2541390
/gene="cyp124"
/locus_tag="Rv2266"
CDS 2540104..2541390
/codon_start=1
/transl_table=11
/gene="cyp124"
/locus_tag="Rv2266"
/product="Probable cytochrome P450 124 Cyp124"
/note="Rv2266, (MT2328, MTCY339.44c), len: 428 aa.
Probable cyp124, cytochrome P450, similar to e.g. G405543
cytochrome P450 (406 aa), FASTA scores, opt: 763,E(): 0,
(35.4% identity in 393 aa overlap), similar to e.g.
MTCY50.26,33.8% identity in 370 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2266"
/db_xref="EnsemblGenomes-Tr:CCP45047"
/db_xref="GOA:P9WPP3"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:2WM4"
/db_xref="PDB:2WM5"
/db_xref="UniProtKB/Swiss-Prot:P9WPP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45047.1"
/translation="MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFA
TLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPE
LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQ
ADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSAD
IGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA
AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVA
FDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS"
gene complement(2541644..2542810)
/locus_tag="Rv2267c"
CDS complement(2541644..2542810)
/codon_start=1
/transl_table=11
/locus_tag="Rv2267c"
/product="Conserved hypothetical protein"
/note="Rv2267c, (MTCY339.43), len: 388 aa. Conserved
hypothetical protein; some similarity to Mycobacterium
tuberculosis Rv3529c; gp|Z82098|MTCY3C7_27 (384 aa) FASTA
score: opt: 261, E(): 3.6e-10; 27.3% identity in 253 aa
overlap. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2267c"
/db_xref="EnsemblGenomes-Tr:CCP45048"
/db_xref="GOA:P9WLG1"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WLG1"
/protein_id="CCP45048.1"
/translation="MKALRSSSRLSRWREWAAPLWVGCNFSAWMRLLIRNRFAVHHSR
WHFAVLYTFLSMVNSCLGLWQKIVFGRRVAETVIADPPIFIVGHWRTGTTLLHELLVV
DDRHTGPTGYECLAPHHFLLTEWFAPYVEFLVSKHRAMDNMDLSLHHPQEDEFVWCMQ
GLPSPYLTIAFPNRPPQYEEYLDLEQVAPRELEIWKRTLFRFVQQVYFRRRKTVILKN
PTHSFRIKVLLEVFPQAKFIHIVRDPYVVYPSTIHLHKALYRIHGLQQPTFDGLDDKV
VSTYVDLYRKLDEGRELVDPTRFYELRYEDLIGDPEGQLRRLYQHLGLGDFECYLPRL
RQYLADHADYKTNSYQLTVEQRAIVDEHWGEIIDRYGYDRHTPEPARLRPAVGG"
gene complement(2542807..2544276)
/gene="cyp128"
/locus_tag="Rv2268c"
CDS complement(2542807..2544276)
/codon_start=1
/transl_table=11
/gene="cyp128"
/locus_tag="Rv2268c"
/product="Probable cytochrome P450 128 Cyp128"
/note="Rv2268c, (MT2330, MTCY339.42), len: 489 aa.
Probable cyp128, cytochrome P450, similar to (but longer
than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome
p-450 107b1 (405 aa), FASTA scores, opt: 620, E():
8.3e-33,(31.8% identity in 406 aa overlap); contains
PS00086 Cytochrome P450 cysteine heme-iron ligand
signature,similar to MTCY50.26, 32.7% identity in 382 aa
overlap. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2268c"
/db_xref="EnsemblGenomes-Tr:CCP45049"
/db_xref="GOA:P9WPN7"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPN7"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP45049.1"
/translation="MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTR
RRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDF
DPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVT
FSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPAD
VVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGF
RRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMI
STLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPA
GSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILR
EIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP"
gene complement(2544289..2544621)
/locus_tag="Rv2269c"
CDS complement(2544289..2544621)
/codon_start=1
/transl_table=11
/locus_tag="Rv2269c"
/product="Hypothetical protein"
/note="Rv2269c, (MTCY339.41), len: 110 aa. Unknown
protein; questionable ORF. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2269c"
/db_xref="EnsemblGenomes-Tr:CCP45050"
/db_xref="GOA:P9WLF9"
/db_xref="UniProtKB/Swiss-Prot:P9WLF9"
/protein_id="CCP45050.1"
/translation="MANDARPLARLANCRVGDQSSATHAYTVGPVLGVPPTGGVDLRY
GGRAGIGRSETVTDHGAVGRRYHQPCAGQIRLSELRVTILLRCETLCETAQLLRCPPL
PCDCSTPL"
gene 2544698..2545225
/gene="lppN"
/locus_tag="Rv2270"
CDS 2544698..2545225
/codon_start=1
/transl_table=11
/gene="lppN"
/locus_tag="Rv2270"
/product="Probable lipoprotein LppN"
/note="Rv2270, (MTCY339.40c), len: 175 aa. Probable
lppN,lipoprotein; has appropriately positioned prokaryotic
membrane lipoprotein attachment site PS00013."
/db_xref="EnsemblGenomes-Gn:Rv2270"
/db_xref="EnsemblGenomes-Tr:CCP45051"
/db_xref="GOA:P9WK73"
/db_xref="UniProtKB/Swiss-Prot:P9WK73"
/protein_id="CCP45051.1"
/translation="MRLPGRHVLYALSAVTMLAACSSNGARGGIASTNMNPTNPPATA
ETATVSPTPAPQSARTETWINLQVGDCLADLPPADLSRITVTIVDCATAHSAEVYLRA
PVAVDAAVVSMANRDCAAGFAPYTGQSVDTSPYSVAYLIDSHQDRTGADPTPSTVICL
LQPANGQLLTGSARR"
gene 2545332..2545631
/locus_tag="Rv2271"
CDS 2545332..2545631
/codon_start=1
/transl_table=11
/locus_tag="Rv2271"
/product="Conserved hypothetical protein"
/note="Rv2271, (MTCY339.39c), len: 99 aa. Conserved
hypothetical protein; some similarity to hypothetical
protein AAK01340.1|AF265275_3 (AF265275) from uncultured
organism Pu8 (104 aa) E= 4e-10, (34% identity in 91 aa
overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2271"
/db_xref="EnsemblGenomes-Tr:CCP45052"
/db_xref="InterPro:IPR024248"
/db_xref="UniProtKB/Swiss-Prot:P9WLF7"
/protein_id="CCP45052.1"
/translation="MTTPPDKARRRFLRDAYKNAERVARTALLTIDQDQLEQLLDYVD
ERLGEQPCDHTARHAQRWAQSHRIEWETLAEGLQEFGGYCDCEIVMNVEPEAIFG"
gene 2545737..2546105
/locus_tag="Rv2272"
CDS 2545737..2546105
/codon_start=1
/transl_table=11
/locus_tag="Rv2272"
/product="Probable conserved transmembrane protein"
/note="Rv2272, (MTCY339.38c), len: 122 aa. Probable
conserved transmembrane protein, similar to YIDH_ECOLI
P31445 hypothetical 12.8 kDa protein (115 aa), FASTA
scores, opt: 291, E(): 2.9e-14, (45.6% identity in 103 aa
overlap), similar to MTCY339.37c, (35.0% identity in 100
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2272"
/db_xref="EnsemblGenomes-Tr:CCP45053"
/db_xref="GOA:P9WLF5"
/db_xref="InterPro:IPR003807"
/db_xref="UniProtKB/Swiss-Prot:P9WLF5"
/protein_id="CCP45053.1"
/translation="MADDSNDTATDVEPDYRFTLANERTFLAWQRTALGLLAAAVALV
QLVPELTIPGARQVLGVVLAILAILTSGMGLLRWQQADRAMRRHLPLPRHPTPGYLAV
GLCVVGVVALALVVAKAITG"
gene 2546102..2546431
/locus_tag="Rv2273"
CDS 2546102..2546431
/codon_start=1
/transl_table=11
/locus_tag="Rv2273"
/product="Probable conserved transmembrane protein"
/note="Rv2273, (MTCY339.37c), len: 109 aa. Probable
conserved transmembrane protein, similar to Rv2272
(MTCY339.38c), (35.0% identity in 100 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2273"
/db_xref="EnsemblGenomes-Tr:CCP45054"
/db_xref="GOA:P9WLF3"
/db_xref="InterPro:IPR003807"
/db_xref="UniProtKB/Swiss-Prot:P9WLF3"
/protein_id="CCP45054.1"
/translation="MNRHSTAASDRGLQAERTTLAWTRTAFALLVNGVLLTLKDTQGA
DGPAGLIPAGLAGAAASCCYVIALQRQRALSHRPLPARITPRGQVHILATAVLVLMVV
TAFAQLL"
gene complement(2546488..2546805)
/gene="mazF8"
/locus_tag="Rv2274c"
CDS complement(2546488..2546805)
/codon_start=1
/transl_table=11
/gene="mazF8"
/locus_tag="Rv2274c"
/product="Possible toxin MazF8"
/note="Rv2274c, (MTCY339.36), len: 105 aa. Possible
mazF8,toxin, part of toxin-antitoxin (TA) operon with
Rv2274A (See Pandey and Gerdes, 2005). Questionable ORF."
/db_xref="EnsemblGenomes-Gn:Rv2274c"
/db_xref="EnsemblGenomes-Tr:CCP45055"
/db_xref="GOA:P9WIH7"
/db_xref="UniProtKB/Swiss-Prot:P9WIH7"
/protein_id="CCP45055.1"
/translation="MSIARSAQPIGWISCPPKGGSSCCRCGGGYTHIFCVSAWTGLVV
DLQAEQVRSVVTERLRRRIGRGAPILAGTLAPGVGLAAQNREFRQFTGRSAPPSATIA
FGE"
gene complement(2546839..2547087)
/gene="mazE8"
/locus_tag="Rv2274A"
CDS complement(2546839..2547087)
/codon_start=1
/transl_table=11
/gene="mazE8"
/locus_tag="Rv2274A"
/product="Possible antitoxin MazE8"
/note="Rv2274A, len: 82 aa. Possible mazE8, antitoxin,
part of toxin-antitoxin (TA) operon with Rv2274c (See
Pandey and Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2274A"
/db_xref="EnsemblGenomes-Tr:CCP45056"
/db_xref="UniProtKB/Swiss-Prot:P0CL60"
/protein_id="CCP45056.1"
/translation="MAEPETLPGRWLPECACLAETVSWEQSRLWSRLLCRPHFRHALP
GLTGGSASRPSARSARLVRQPRMTLFSLDHRDGVDARC"
gene 2546883..2547752
/locus_tag="Rv2275"
CDS 2546883..2547752
/codon_start=1
/transl_table=11
/locus_tag="Rv2275"
/product="Conserved hypothetical protein"
/note="Rv2275, (MTCY339.35c), len: 289 aa. Conserved
hypothetical protein. Some similarity to Bacillus subtilis
sp|O34351|O34351 YVMC (248 aa), FASTA score: opt: 280,
E(): 2.7e -11; 28.2% identity in 227 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2275"
/db_xref="EnsemblGenomes-Tr:CCP45057"
/db_xref="GOA:P9WPF9"
/db_xref="InterPro:IPR030903"
/db_xref="InterPro:IPR038622"
/db_xref="PDB:2X9Q"
/db_xref="UniProtKB/Swiss-Prot:P9WPF9"
/protein_id="CCP45057.1"
/translation="MSYVAAEPGVLISPTDDLQSPRSAPAAHDENADGITGGTRDDSA
PNSRFQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDL
GLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDP
AGARLCVRPMSEFQSNEAYRELHADLLTRLKDDEDLRAVCQDLVRRFLSTKVGPRQGA
TATQEQVCMDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQ
GHAIVTPDGSPAE"
gene 2547749..2548939
/gene="cyp121"
/locus_tag="Rv2276"
CDS 2547749..2548939
/codon_start=1
/transl_table=11
/gene="cyp121"
/locus_tag="Rv2276"
/product="Cytochrome P450 121 Cyp121"
/note="Rv2276, (MT2336, MTCY339.34c), len: 396 aa.
Cyp121,cytochrome P450 (see citation below), similar to
e.g. G303644 (397 aa) opt: 675, z-score: 776.4, E():
2.7e-36,(33.7% identity in 407 aa overlap); contains
PS00086 Cytochrome P450 cysteine heme-iron ligand
signature,similar to MTCY339.42, 29.2% identity in 298 aa
overlap."
/db_xref="EnsemblGenomes-Gn:Rv2276"
/db_xref="EnsemblGenomes-Tr:CCP45058"
/db_xref="GOA:P9WPP7"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:1N40"
/db_xref="PDB:1N4G"
/db_xref="PDB:2IJ5"
/db_xref="PDB:2IJ7"
/db_xref="PDB:3CXV"
/db_xref="PDB:3CXX"
/db_xref="PDB:3CXY"
/db_xref="PDB:3CXZ"
/db_xref="PDB:3CY0"
/db_xref="PDB:3CY1"
/db_xref="PDB:3G5F"
/db_xref="PDB:3G5H"
/db_xref="PDB:4G1X"
/db_xref="PDB:4G2G"
/db_xref="PDB:4G44"
/db_xref="PDB:4G45"
/db_xref="PDB:4G46"
/db_xref="PDB:4G47"
/db_xref="PDB:4G48"
/db_xref="PDB:4ICT"
/db_xref="PDB:4IPS"
/db_xref="PDB:4IPW"
/db_xref="PDB:4IQ7"
/db_xref="PDB:4IQ9"
/db_xref="PDB:5IBD"
/db_xref="PDB:5IBE"
/db_xref="PDB:5IBF"
/db_xref="PDB:5IBG"
/db_xref="PDB:5IBH"
/db_xref="PDB:5IBI"
/db_xref="PDB:5IBJ"
/db_xref="PDB:5OP9"
/db_xref="UniProtKB/Swiss-Prot:P9WPP7"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP45058.1"
/translation="MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWL
VSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAI
TPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKL
FRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHV
SDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRI
NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTS
HLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERL
PVLW"
gene complement(2549124..2550029)
/locus_tag="Rv2277c"
CDS complement(2549124..2550029)
/codon_start=1
/transl_table=11
/locus_tag="Rv2277c"
/product="Possible glycerolphosphodiesterase"
/note="Rv2277c, (MTCY339.33), len: 301 aa. Possible
glycerolphosphodiesterase, similar to e.g. UGPQ_ECOLI
P10908 glycerophosphoryldiester phosphodiesterase
(cytosolic) (247 aa), FASTA scores, opt: 149, E():
0.0061,(27.2% identity in 195 aa overlap). Start of
protein uncertain, encoded by neighbouring IS6110 as
given, is intact in Mycobacterium tuberculosis CDC1551"
/db_xref="EnsemblGenomes-Gn:Rv2277c"
/db_xref="EnsemblGenomes-Tr:CCP45059"
/db_xref="GOA:P9WLF1"
/db_xref="InterPro:IPR017946"
/db_xref="InterPro:IPR030395"
/db_xref="PDB:5VUG"
/db_xref="UniProtKB/Swiss-Prot:P9WLF1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45059.1"
/translation="MPGRFTVALVIALGGTCGVADALPLGQTDDPMIVAHRAGTRDFP
ENTVLAITNAVAAGVDGMWLTVQVSSDGVPVLYRPSDLATLTDGAGPVNSKTVQQLQQ
LNAGWNFTTPGVEGHPYRQRATPIPTLEQAIGATPPDMTLFLDLKQTPPQPLVSAVAQ
VLTRTGAAGRSIVYSTNADITAAASRQEGLQVAESRDVTRQRLFNMALNHHCDPQPDP
GKWAGFELHRDVTVTEEFTLGSGISAVNAELWDEASVDCFRSQSGMKVMGFAVKTVDD
YRLAHKIGLDAVLVDSPLAAQQWRH"
repeat_region 2550011..2550013
/note="3 bp direct repeat, ccg, flanking IS6110"
mobile_element 2550014..2551368
/mobile_element_type="insertion sequence:IS6110-7"
/note="IS6110-7, len: 1355 nt. Insertion sequence IS6110."
repeat_region 2550014..2550041
/note="28 bp inverted repeat at the left end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene 2550065..2550391
/locus_tag="Rv2278"
CDS 2550065..2550391
/codon_start=1
/transl_table=11
/locus_tag="Rv2278"
/product="Putative transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv2278, (MTCY339.32c), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv2278 and
Rv2279,the sequence UUUUAAAG (directly upstream of Rv2279)
maybe responsible for such a frameshifting event (see
McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv2278"
/db_xref="EnsemblGenomes-Tr:CCP45060"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP45060.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <2550340..2551326
/locus_tag="Rv2279"
CDS <2550340..2551326
/codon_start=1
/transl_table=11
/locus_tag="Rv2279"
/product="Probable transposase"
/note="Rv2279, (MTCY339.31c), len: 328 aa. Probable IS6110
transposase. Identical to many other M. tuberculosis
IS6110 transposase subunits. The transposase described
here may be made by a frame shifting mechanism during
translation that fuses Rv2278 and Rv2279, the sequence
UUUUAAAG (directly upstream of Rv2279) maybe responsible
for such a frameshifting event (see McAdam et al., 1990).
Start changed since first submission (+ 16 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2279"
/db_xref="EnsemblGenomes-Tr:CCP45061"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP45061.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region 2551341..2551368
/note="28 bp inverted repeat at the right end of
IS6110,GAGTCTCCGGACTCACCGGGGCGGTTCA"
repeat_region 2551369..2551371
/note="3 bp direct repeat, ccg, flanking IS6110"
gene 2551560..2552939
/locus_tag="Rv2280"
CDS 2551560..2552939
/codon_start=1
/transl_table=11
/locus_tag="Rv2280"
/product="Probable dehydrogenase"
/note="Rv2280, (MTCY339.30c), len: 459 aa. Probable
dehydrogenase. Similar to D-lactate dehydrogenase
(cytochrome) precursor e.g. G1061264 (587 aa), FASTA
scores, opt: 645,E(): 1.3e-31, (28.0% identity in 478 aa
overlap), similar to MTCY50.25, 36.5% identity in 447 aa
overlap"
/db_xref="EnsemblGenomes-Gn:Rv2280"
/db_xref="EnsemblGenomes-Tr:CCP45062"
/db_xref="GOA:P9WIT1"
/db_xref="InterPro:IPR004113"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016164"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016171"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/Swiss-Prot:P9WIT1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45062.1"
/translation="MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAA
KPATPEEVAQLLKAASENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEVDTA
NQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSSVGGNVGTNAGGMRAVKYGVARH
NVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSEGTLALVTEVIVKLHPRLDHN
ASVLAPFADFDQVMAAVPKILASGLAPDILEYIDNTSMAALISTQNLELGIPDQIRDS
CEAYLLVALENRIADRLFEDIQTVGEMLMELGAVDAYVLEGGSARKLIEAREKAFWAA
KALGADDIIDTVVPRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDPEK
KKKLMTDIFALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQSFDPAGIL
NPGVVFGDT"
gene 2553173..2554831
/gene="pitB"
/locus_tag="Rv2281"
CDS 2553173..2554831
/codon_start=1
/transl_table=11
/gene="pitB"
/locus_tag="Rv2281"
/product="Putative phosphate-transport permease PitB"
/note="Rv2281, (MTCY339.29c), len: 552 aa. Putative
pitB,phosphate-transport permease, integral membrane
protein,similar to YG04_HAEIN P45268 putative phosphate
permease hi1604 (420 aa). FASTA scores, opt: 484, E():
5e-23, (33.5% identity in 498 aa overlap) also to G399598
amphotropic murine retrovirus receptor (656 aa) FASTA
scores, opt: 453,E(): 5.8e-21, (26.8% identity in 645 aa
overlap). Also similar to Rv0545c|pitA from M.
tuberculosis. Belongs to the pit subfamily."
/db_xref="EnsemblGenomes-Gn:Rv2281"
/db_xref="EnsemblGenomes-Tr:CCP45063"
/db_xref="GOA:P9WIA5"
/db_xref="InterPro:IPR001204"
/db_xref="UniProtKB/Swiss-Prot:P9WIA5"
/protein_id="CCP45063.1"
/translation="MSDNAKHHRDGHLVASGLQDRAARTPQHEGFLGPDRPWHLSFSL
LLAGSFVLFSWWAFDYAGSGANKVILVLATVVGMFMAFNVGGNDVANSFGTSVGAGTL
TMKQALLVAAIFEVSGAVIAGGDVTETIRSGIVDLSGVSVDPRDFMNIMLSALSAAAL
WLLFANRMGYPVSTTHSIIGGIVGAAIALGMVSGQGGAALRMVQWDQIGQIVVSWVLS
PVLGGLVSYLLYGVIKRHILLYNEQAERRLTEIKKERIAHRERHKAAFDRLTEIQQIA
YTGALARDAVAANRKDFDPDELESDYYRELHEIDAKTSSVDAFRALQNWVPLVAAAGS
MIIVAMLLFKGFKHMHLGLTTMNNYFIIAMVGAAVWMATFIFAKTLRGESLSRSTFLM
FSWMQVFTASGFAFSHGSNDIANAIGPFAAILDVLRTGAIEGNAAVPAAAMVTFGVAL
CAGLWFIGRRVIATVGHNLTTMHPASGFAAELSAAGVVMGATVLGLPVSSTHILIGAV
LGVGIVNRSTNWGLMKPIVLAWVITLPSAAILASVGLVALRAIF"
gene complement(2554938..2555876)
/locus_tag="Rv2282c"
CDS complement(2554938..2555876)
/codon_start=1
/transl_table=11
/locus_tag="Rv2282c"
/product="Probable transcription regulator (LysR family)"
/note="Rv2282c, (MTCY339.28), len: 312 aa. Probable
transcriptional regulator, lysR family, similar to others
e.g. YC30_CYAPA|P48271 hypothetical transcriptional
regulator YCF30 (324 aa), FASTA scores: opt: 292, E():
4e-12, (27.6% identity in 286 aa overlap); etc. Also
similar to Rv0377|MTCY39.34 from Mycobacterium
tuberculosis, FASTA score: (25.4% identity in 268 aa
overlap). Contains PS00044 Bacterial regulatory
proteins,lysR family signature, and contains
helix-turn-helix motif at aa 24 -45 (+4.93 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2282c"
/db_xref="EnsemblGenomes-Tr:CCP45064"
/db_xref="GOA:P9WMF3"
/db_xref="InterPro:IPR000847"
/db_xref="InterPro:IPR005119"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMF3"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45064.1"
/translation="MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRRLA
SMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSLRTEGRQRIRV
VASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSEHAIAAVRDGIADLGFIEN
PCPPTGLGSVVVARDELVVVVPPGHKWARRSRVVSARELAQTPLVTREPNSGIRDSLT
AALRDTLGEDMQQAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDI
PALNLRRQLRAIWVGGRTPPAGAIRDLLSHITSRST"
gene 2555941..2556135
/locus_tag="Rv2283"
CDS 2555941..2556135
/codon_start=1
/transl_table=11
/locus_tag="Rv2283"
/product="Hypothetical protein"
/note="Rv2283, (MTCY339.27c), len: 64 aa. Unknown protein;
questionable ORF."
/db_xref="EnsemblGenomes-Gn:Rv2283"
/db_xref="EnsemblGenomes-Tr:CCP45065"
/db_xref="UniProtKB/Swiss-Prot:P9WLE9"
/protein_id="CCP45065.1"
/translation="MLEKCPHASVDCGASKIGITDNDPATATNRRLASTIRKPPIEHA
AGPLGSTSRAGHRSYGGVAS"
gene 2556145..2557440
/gene="lipM"
/locus_tag="Rv2284"
CDS 2556145..2557440
/codon_start=1
/transl_table=11
/gene="lipM"
/locus_tag="Rv2284"
/product="Probable esterase LipM"
/note="Rv2284, (MTCY339.26c), len: 431 aa. Probable
lipM,esterase, similar to others e.g. gp|Z95844|MTCY493_28
from Mycobacterium tuberculosis cosmid (420 aa), FASTA
scores: opt: 1266, E(): 0, (50.1% identity in 411 aa
overlap). Some similarity to G537514 arylacetamide
deacetylase (399 aa),FASTA scores: opt: 190, E(): 5.9e-05,
(30.4% identity in 138 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2284"
/db_xref="EnsemblGenomes-Tr:CCP45066"
/db_xref="GOA:Q50681"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:Q50681"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45066.1"
/translation="MGAPRLIHVIRQIGALVVAAVTAAATINAYRPLARNGFASLWSW
FIGLVVTEFPLPTLASQLGGLVLTAQRLTRPVRAVSWLVAAFSALGLLNLSRAGRQAD
AQLTAALDSGLGPDRRTASAGLWRRPAGGGTAKTPGPLRMLRIYRDYAHDGDISYGEY
GRANHLDIWRRPDLDLTGTAPVLFQIPGGAWTTGNKRGQAHPLMSHLAELGWICVAIN
YRHSPRNTWPDHIIDVKRALAWVKAHISEYGGDPDFIAITGGSAGGHLSSLAALTPND
PRFQPGFEEADTRVQAAVPFYGVYDFTRLQDAMHPMMLPLLERMVVKQPRTANMQSYL
DASPVTHISADAPPFFVLHGRNDSLVPVQQARGFVDQLRQVSKQPVVYAELPFTQHAF
DLLGSARAAHTAIAVEQFLAEVYATQHAGSEPGPAVAIP"
gene 2557473..2558810
/locus_tag="Rv2285"
CDS 2557473..2558810
/codon_start=1
/transl_table=11
/locus_tag="Rv2285"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv2285, (MTCY339.25c), len: 445 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004), member
of Mycobacterium tuberculosis 15-membered protein family
including Rv3740c, Rv3734c, Rv1425, Rv1760,
Rv0895,Rv3480c. FASTA scores: gp|Z95844|MTCY493_29
Mycobacterium tuberculosis cosmid (459 aa) opt: 640, E():
0; 33.4% identity in 470 aa overlap."
/db_xref="EnsemblGenomes-Gn:Rv2285"
/db_xref="EnsemblGenomes-Tr:CCP45067"
/db_xref="GOA:P9WKB5"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45067.1"
/translation="MKLLSPLDQMFARMEAPRTPMHIGAFAVFDLPKGAPRRFIRDLY
EAISQLAFLPFPFDSVIAGGASMAYWRQVQPDPSYHVRLSALPYPGTGRDLGALVERL
HSTPLDMAKPLWELHLIEGLTGRQFAMYFKAHHCAVDGLGGVNLIKSWLTTDPEAPPG
SGKPEPFGDDYDLASVLAAATTKRAVEGVSAVSELAGRLSSMVLGANSSVRAALTTPR
TPFNTRVNRHRRLAVQVLKLPRLKAVAHATDCTVNDVILASVGGACRRYLQELGDLPT
NTLTASVPVGFERDADTVNAASGFVAPLGTSIEDPVARLTTISASTTRGKAELLAMSP
NALQHYSVFGLLPIAVGQKTGALGVIPPLFNFTVSNVVLSKDPLYLSGAKLDVIVPMS
FLCDGYGLNVTLVGYTDKVVLGFLGCRDTLPHLQRLAQYTGAAFEELETAALP"
gene complement(2558877..2559569)
/locus_tag="Rv2286c"
CDS complement(2558877..2559569)
/codon_start=1
/transl_table=11
/locus_tag="Rv2286c"
/product="Conserved hypothetical protein"
/note="Rv2286c, (MTCY339.24), len: 230 aa. Conserved
hypothetical protein. Similar to Mycobacterium
tuberculosis hypothetical protein, Rv2466c,
AL021246|MTV008_22 (207 aa). FASTA score: opt: 324, E():
8.9e-15; 30.4% identity in 194 aa overlap"
/db_xref="EnsemblGenomes-Gn:Rv2286c"
/db_xref="EnsemblGenomes-Tr:CCP45068"
/db_xref="GOA:P9WLE7"
/db_xref="InterPro:IPR001853"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/Swiss-Prot:P9WLE7"
/protein_id="CCP45068.1"
/translation="MTTVDFHFDPLCPFAYQTSVWIRDVRAQLGITINWRFFSLEEIN
LVAGKKHPWERDWSYGWSLMRIGALLRRTNMSLLDRWYAAIGHELHTLGGKPHDPAVA
RRLLCDVGVNAAILDAALDDPTTHDDVRADHQRVVAAGGYGVPTLFLDGQCLFGPVLV
DPPAGPAALNLWSVVTGMAGLPHVYELQRPKSPADVELIAQQLRPYLDGRDWVSINRG
EIVDIDRLAGRS"
gene 2559703..2561331
/gene="yjcE"
/locus_tag="Rv2287"
CDS 2559703..2561331
/codon_start=1
/transl_table=11
/gene="yjcE"
/locus_tag="Rv2287"
/product="Probable conserved integral membrane transport
protein YjcE"
/note="Rv2287, (MTCY339.23c), len: 542 aa. Probable
yjcE,conserved integral membrane transport protein,
similar to eukaryote NA+/H+ exchangers e.g.
YJCE_ECOLI|P32703|B4065 Putative Na(+)/H(+) exchanger from
Escherichia coli (549 aa), FASTA scores: opt: 436, E():
5.6e-21, (29.4% identity in 555 aa overlap); etc. Seems to
belong to CPA1 family (NA(+)/H(+) exchanger family)."
/db_xref="EnsemblGenomes-Gn:Rv2287"
/db_xref="EnsemblGenomes-Tr:CCP45069"
/db_xref="GOA:P9WJI3"
/db_xref="InterPro:IPR004705"
/db_xref="InterPro:IPR006153"
/db_xref="InterPro:IPR018422"
/db_xref="UniProtKB/Swiss-Prot:P9WJI3"
/protein_id="CCP45069.1"
/translation="MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLL
ILSGSLLGLIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIVMFSIGL
VIATAVAVSWTARALGMESHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLI
NDGTALVLFAVTVAVAEGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDA
PLEEGALSLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWD
IATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATRIAWVQATT
VLGHTVDRVLKKPTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLI
IFVVSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQAALDALPTVAD
ELGVAPDLVKHLEKEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQHQRQAVT
TLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE"
gene 2561328..2561705
/locus_tag="Rv2288"
CDS 2561328..2561705
/codon_start=1
/transl_table=11
/locus_tag="Rv2288"
/product="Hypothetical protein"
/note="Rv2288, (MTCY339.22c), len: 125 aa. Unknown
hypothetical protein"
/db_xref="EnsemblGenomes-Gn:Rv2288"
/db_xref="EnsemblGenomes-Tr:CCP45070"
/db_xref="GOA:P9WLE5"
/db_xref="UniProtKB/Swiss-Prot:P9WLE5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45070.1"
/translation="MSRRRPLIEPATVQVLAIAFTDSFSVSLHWPQREQGCRTAILAP
MRRWCDGDVDGRKLLPPARRTGTQQRRIRPAAPRVYTTGDILRDRKGIAPWQEQREPG
WAPFGWLHEPSGARCPKADGQSV"
gene 2561675..2562457
/gene="cdh"
/locus_tag="Rv2289"
CDS 2561675..2562457
/codon_start=1
/transl_table=11
/gene="cdh"
/locus_tag="Rv2289"
/product="Probable CDP-diacylglycerol pyrophosphatase Cdh
(CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol
phosphatidylhydrolase)"
/note="Rv2289, (MTCY339.21c), len: 260 aa. Probable
cdh,CDP-diacylglycerol pyrophosphatase, similar to
CDH_SALTY|P26219 cdp-diacylglycerol pyrophosphatase (251
aa), FASTA scores: opt: 395, E(): 5.9e-20, (33.5% identity
in 221 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2289"
/db_xref="EnsemblGenomes-Tr:CCP45071"
/db_xref="GOA:P9WPG9"
/db_xref="InterPro:IPR003763"
/db_xref="InterPro:IPR036265"
/db_xref="InterPro:IPR038433"
/db_xref="UniProtKB/Swiss-Prot:P9WPG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45071.1"
/translation="MPKSRRAVSLSVLIGAVIAALAGALIAVTVPARPNRPEADREAL
WKIVHDRCEFGYRRTGAYAPCTFVDEQSGTALYKADFDPYQFLLIPLARITGIEDPAL
RESAGRNYLYDAWAARFLVTARLNNSLPESDVVLTINPKNARTQDQLHIHISCSSPTT
SAALRNVDTSEYVGWKQLPIDLGGRRFQGLAVDTKAFESRNLFRDIYLKVTADGKKME
NASIAVANVAQDQFLLLLAEGTEDQPVAAETLQDHDCSITKS"
gene 2562599..2563114
/gene="lppO"
/locus_tag="Rv2290"
CDS 2562599..2563114
/codon_start=1
/transl_table=11
/gene="lppO"
/locus_tag="Rv2290"
/product="Probable conserved lipoprotein LppO"
/note="Rv2290, (MTCY339.20c), len: 171 aa. Probable
lppO,conserved lipoprotein, similar to Rv3763, 19KD_MYCTU
P11572 19 kDa lipoprotein antigen precursor (159 aa) FASTA
scores,opt: 119, E (): 1.3, (25.6% identity in 164 aa
overlap). Contains appropriately positioned PS00013
lipoprotein motif (with one mismatch). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2290"
/db_xref="EnsemblGenomes-Tr:CCP45072"
/db_xref="GOA:P9WK71"
/db_xref="InterPro:IPR008691"
/db_xref="UniProtKB/Swiss-Prot:P9WK71"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45072.1"
/translation="MTDPRHTVRIAVGATALGVSALGATLPACSAHSGPGSPPSAPSA
PAAATVMVEGHTHTISGVVECRTSPAVRTATPSESGTQTTRVNAHDDSASVTLSLSDS
TPPDVNGFGISLKIGSVDYQMPYQPVQSPTQVEATRQGKSYTLTGTGHAVIPGQTGMR
ELPFGVHVTCP"
gene 2563174..2564028
/gene="sseB"
/locus_tag="Rv2291"
CDS 2563174..2564028
/codon_start=1
/transl_table=11
/gene="sseB"
/locus_tag="Rv2291"
/product="Probable thiosulfate sulfurtransferase SseB"
/note="Rv2291, (MTCY339.19c), len: 284 aa. Probable
sseB,thiosulfate sulfurtransferase. Very similar to
thiosulfate sulfurtransferas/rhodanese from Streptomyces
coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0;
Smith-Waterman score: 765; 46.9% identity in 286 aa
overlap, similar to THTR_ECOLI P31142 putative thiosulfate
sulfurtransferase (280 aa), FASTA scores, opt: 478, E():
1e-23, (35.1% identity in 265 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2291"
/db_xref="EnsemblGenomes-Tr:CCP45073"
/db_xref="GOA:P9WHF5"
/db_xref="InterPro:IPR001307"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR036873"
/db_xref="UniProtKB/Swiss-Prot:P9WHF5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45073.1"
/translation="MQARGQVLITAAELAGMIQAGDPVSILDVRWRLDEPDGHAAYLQ
GHLPGAVFVSLEDELSDHTIAGRGRHPLPSGASLQATVRRCGIRHDVPVVVYDDWNRA
GSARAWWVLTAAGIANVRILDGGLPAWRSAGGSIETGQVSPQLGNVTVLHDDLYAGQR
LTLTAQQAGAGGVTLLDARVPERFRGDVEPVDAVAGHIPGAINVPSGSVLADDGTFLG
NGALNALLSDHGIDHGGRVGVYCGSGVSAAVIVAALAVIGQDAELFPGSWSEWSSDPT
RPVGRGTA"
gene complement(2564029..2564253)
/locus_tag="Rv2292c"
CDS complement(2564029..2564253)
/codon_start=1
/transl_table=11
/locus_tag="Rv2292c"
/product="Hypothetical protein"
/note="Rv2292c, (MTCY339.18), len: 74 aa. Unknown
hypothetical protein"
/db_xref="EnsemblGenomes-Gn:Rv2292c"
/db_xref="EnsemblGenomes-Tr:CCP45074"
/db_xref="GOA:P9WLE3"
/db_xref="InterPro:IPR000845"
/db_xref="InterPro:IPR035994"
/db_xref="UniProtKB/Swiss-Prot:P9WLE3"
/protein_id="CCP45074.1"
/translation="MNPGFDAVDQETAAAQAVADAHGVPFLGIRGMSDGPGDPLHLPG
FPVQFFVYKQIAANNAARVTEAFLQNWAGV"
gene complement(2564292..2565032)
/locus_tag="Rv2293c"
CDS complement(2564292..2565032)
/codon_start=1
/transl_table=11
/locus_tag="Rv2293c"
/product="Conserved hypothetical protein"
/note="Rv2293c, (MTCY339.17), len: 246 aa. Conserved
hypothetical protein; some similarity to hypothetical
protein (299 aa) AAK24237.1| (AE005897) belonging to
phosphorylase family [Caulobacter crescentus] (33%
identity in 131 aa overlap). Possible lipoprotein: signal
peptide at N-terminus"
/db_xref="EnsemblGenomes-Gn:Rv2293c"
/db_xref="EnsemblGenomes-Tr:CCP45075"
/db_xref="GOA:P9WLE1"
/db_xref="InterPro:IPR000845"
/db_xref="InterPro:IPR035994"
/db_xref="UniProtKB/Swiss-Prot:P9WLE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45075.1"
/translation="MGAPLRHCLLVAAALSLGCGVAAADPGYVANVIPCEQRTLVLSA
FPAEADAVLAHTALDANPVVVADRRRYYLGSISGKKVIVAMTGIGLVNATNTTETAFA
RFTCASSIAIAAVMFSGVAGGAGRTSIGDVAIPARWTLDNGATFRGVDPGMLATAQTL
SVVLDNINTLGNPVCLCRNVPVVRLNHLGRQPQLFVGGDGSSSDKNNGQAFPCIPNGG
SVFAANPVVHPIAHLAIPVTFSRRRDPG"
gene 2565327..2566550
/locus_tag="Rv2294"
CDS 2565327..2566550
/codon_start=1
/transl_table=11
/locus_tag="Rv2294"
/product="Probable aminotransferase"
/note="Rv2294, (MTCY339.16c), len: 407 aa. Probable
aminotransferase, similar to others in M. tuberculosis
e.g. MTV030_19, also similar to PATB_BACSU|Q08432 putative
aminotransferase b from Bacillus subtilis (387 aa), FASTA
scores: opt: 563, E(): 2.8e-29, (31.4% identity in 408 aa
overlap); and to MALY_ECOLI|P23256 maly protein from
Escherichia coli (390 aa), FASTA scores: opt: 530, E():
3.6e-27, (31.3% identity in 384 aa overlap). Belongs to
class-II of pyridoxal-phosphate-dependent
aminotransferases."
/db_xref="EnsemblGenomes-Gn:Rv2294"
/db_xref="EnsemblGenomes-Tr:CCP45076"
/db_xref="GOA:P9WQ83"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WQ83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45076.1"
/translation="MIPNPLEELTLEQLRSQRTSMKWRAHPADVLPLWVAEMDVKLPP
TVADALRRAIDDGDTGYPYGTEYAEAVREFACQRWQWHDLEVSRTAIVPDVMLGIVEV
LRLITDRGDPVIVNSPVYAPFYAFVSHDGRRVIPAPLRGDGRIDLDALQEAFSSARAS
SGSSGNVAYLLCNPHNPTGSVHTADELRGIAERAQRFGVRVVSDEIHAPLIPSGARFT
PYLSVPGAENAFALMSASKAWNLGGLKAALAIAGREAAADLARMPEEVGHGPSHLGVI
AHTAAFRTGGNWLDALLRGLDHNRTLLGALVDEHLPGVQYRWPQGTYLAWLDCRELGF
DDAASDEMTEGLAVVSDLSGPARWFLDHARVALSSGHVFGIGGAGHVRINFATSRAIL
IEAVSRMSRSLLERR"
gene 2566772..2567410
/locus_tag="Rv2295"
CDS 2566772..2567410
/codon_start=1
/transl_table=11
/locus_tag="Rv2295"
/product="Conserved hypothetical protein"
/note="Rv2295, (MTCY339.15c), len: 212 aa. Conserved
hypothetical protein, cysteine-rich protein, similar to
YIEJ_ECOLI P31469 hypothetical 22.5 kDa protein in
tnab-bglb intergenic region (195 aa), opt: 270, E():
3.4e-11, (36.4% identity in 198 aa overlap). Alternative
start suggested by similarity 26 codons further
downstream"
/db_xref="EnsemblGenomes-Gn:Rv2295"
/db_xref="EnsemblGenomes-Tr:CCP45077"
/db_xref="GOA:P9WFL7"
/db_xref="InterPro:IPR005363"
/db_xref="UniProtKB/Swiss-Prot:P9WFL7"
/protein_id="CCP45077.1"
/translation="MDQSANHACLPTPLASTTGRGQDHEMPVEETSTPQKLPQFRYHP
DPVGTGSIVADEVSCVSCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATF
TDAMWAVPDDVPEDVTEEVLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPD
ALDALRNEYRGYDWPADKIEEFILTLDRNGLATAYLFRCLSCGVHLAYADFA"
gene 2567504..2568406
/locus_tag="Rv2296"
CDS 2567504..2568406
/codon_start=1
/transl_table=11
/locus_tag="Rv2296"
/product="Probable haloalkane dehalogenase"
/note="Rv2296, (MTCY339.14c), len: 300 aa. Probable
haloalkane dehalogenase, similar to e.g. HALO_XANAU
P22643,haloalkane dehalogenase, (310 aa), opt: 510
z-score: 577.7 E(): 3.1e-25 (39.0% identity in 315 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2296"
/db_xref="EnsemblGenomes-Tr:CCP45078"
/db_xref="GOA:P9WMS3"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR023489"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WMS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45078.1"
/translation="MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEGPG
DGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKPTRIEDYTYLRHV
EWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARLVVANGFLPAAQGRTPLP
FYVWRAFARYSPVLPAGRLVNFGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPT
SPDDPAVPANRAAWEALGRWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIK
ASHFIQEDSGTELAERMLSWQQAT"
gene 2568438..2568890
/locus_tag="Rv2297"
CDS 2568438..2568890
/codon_start=1
/transl_table=11
/locus_tag="Rv2297"
/product="Unknown protein"
/note="Rv2297, (MTCY339.13c), len: 150 aa. Unknown
protein; contains PS00343 Gram-positive cocci surface
proteins 'anchoring' hexapeptide"
/db_xref="EnsemblGenomes-Gn:Rv2297"
/db_xref="EnsemblGenomes-Tr:CCP45079"
/db_xref="GOA:P9WLD9"
/db_xref="UniProtKB/Swiss-Prot:P9WLD9"
/inference="protein motif:PROSITE:PS00343"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45079.1"
/translation="MAMEMAMMGLLGTVVGASAMGIGGIAKSIAEAYVPGVAAAKDRR
QQMNVDLQARRYEAVRVWRSGLCSASNAYRQWEAGSRDTHAPNVVGDEWFEGLRPHLP
TTGEAAKFRTAYEVRCDNPTLMVLSLEIGRIEKEWMVEASGRTPKHRG"
gene 2569082..2570053
/locus_tag="Rv2298"
CDS 2569082..2570053
/codon_start=1
/transl_table=11
/locus_tag="Rv2298"
/product="Conserved protein"
/note="Rv2298, (MTCY339.12c), len: 323 aa. Conserved
protein. Similar to SLR0545 Synechocystis sp, Q55493
hypothetical 34.6 kDa protein (314 aa), FASTA scores, opt:
427, E(): 1.7e-20, (39.3% identity in 303 aa overlap) and
to YZAE_BACSU P46905 hypothetical protein in natb 3'region
(268 aa) FASTA scores, opt: 370, E(): 6.1e-17, (31.4%
identity in 264 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2298"
/db_xref="EnsemblGenomes-Tr:CCP45080"
/db_xref="GOA:P9WQA7"
/db_xref="InterPro:IPR023210"
/db_xref="InterPro:IPR036812"
/db_xref="UniProtKB/Swiss-Prot:P9WQA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45080.1"
/translation="MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKR
ARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERAS
ARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAA
LGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGV
RALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQ
LEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR"
gene complement(2570059..2572002)
/gene="htpG"
/locus_tag="Rv2299c"
CDS complement(2570059..2572002)
/codon_start=1
/transl_table=11
/gene="htpG"
/locus_tag="Rv2299c"
/product="Probable chaperone protein HtpG (heat shock
protein) (HSP90 family protein) (high temperature protein
G)"
/note="Rv2299c, (MTCY339.11), len: 647 aa. HtpG, probable
chaperone, heat shock protein 90 family. Similar to
HTPG_BACSU|P46208 heat shock protein htpG homologue from
Bacillus subtilis (626 aa), FASTA scores: opt: 1551, E():
0, (39.6% identity in 631 aa overlap). Contains possible
helix-turn-helix motif at aa 519-540 (+3.77 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2299c"
/db_xref="EnsemblGenomes-Tr:CCP45081"
/db_xref="GOA:P9WMJ7"
/db_xref="InterPro:IPR001404"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR019805"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR020575"
/db_xref="InterPro:IPR036890"
/db_xref="InterPro:IPR037196"
/db_xref="UniProtKB/Swiss-Prot:P9WMJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45081.1"
/translation="MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDAL
DKLRIEALRNKDLEVDTSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGTLAKSG
TAELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGE
GTYTIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDV
ERRTPASQEEGGEGGEETVTIETETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDD
PLEIIAMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEY
LRFVKGVVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFW
TQFGRVLKEGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKDGQQQIFYATG
ETRQQLLKSPHLEAFKAKGYEVLLLTDPVDEVWVGMVPEFDGKPLQSVAKGEVDLSSE
EDTSEAEREERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFGMTPALA
RIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLA
EGGALEDPARFAELLAERLARTL"
gene complement(2572076..2573008)
/locus_tag="Rv2300c"
CDS complement(2572076..2573008)
/codon_start=1
/transl_table=11
/locus_tag="Rv2300c"
/product="Conserved protein"
/note="Rv2300c, (MTCY339.09), len: 310 aa (start
uncertain). Conserved protein, similar to others e.g.
Q9RXY2|DR0172 conserved hypothetical protein from
Deinococcus radiodurans (271 aa), FASTA scores: opt:
306,E(): 1.3e-12, (34.6% identity in 229 aa overlap);
Q9HZH1|PA3037 hypothetical protein from Pseudomonas
aeruginosa (288 aa), FASTA scores: opt: 248, E():
7.9e-09,(31.5% identity in 238 aa overlap); Q9PDL8|XF1361
hypothetical protein from Xylella fastidiosa (279
aa),FASTA scores: opt: 236, E(): 4.6e-08, (29.7% identity
in 249 aa overlap); U70053|XCU70053_3 GumP protein from
Xanthomonas campestris (282 aa), FASTA scores: opt:
222,E(): 3.7e-07, (30.1% identity in 248 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2300c"
/db_xref="EnsemblGenomes-Tr:CCP45082"
/db_xref="GOA:P9WLD7"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/Swiss-Prot:P9WLD7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45082.1"
/translation="MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAP
EAKGPPVKVHHLNCGTMNAFGIALLCHVLLVETDDGLVLVDTGFGIQDCLDPGRVGLF
RHVLRPAFLQAETAARQIEQLGYRTSDVRHIVLTHFDFDHIGGIADFPEAHLHVTAAE
ARGAIHAPSLRERLRYRRGQWAHGPKLVEHGPDGEPWRGFASAKPLDSIGTGVVLVPM
PGHTRGHAAVAVDAGHRWVLHCGDAFYHRGTLDGRFRVPFVMRAEEKLLSYNRNQLRD
NQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA"
gene 2573015..2573707
/gene="cut2"
/gene_synonym="cfp25"
/gene_synonym="clp2"
/gene_synonym="culp2"
/locus_tag="Rv2301"
CDS 2573015..2573707
/codon_start=1
/transl_table=11
/gene="cut2"
/gene_synonym="cfp25"
/gene_synonym="clp2"
/gene_synonym="culp2"
/locus_tag="Rv2301"
/product="Probable cutinase Cut2"
/note="Rv2301, (MTCY339.08c), len: 230 aa. Probable cut2
(alternate gene name: cfp25), cutinase, highly similar to
others from Mycobacteria tuberculosis e.g.
MTCY13E12.04|Rv3451|O06318|CUT3_MYCTU (247 aa), FASTA
scores: opt: 569, E(): 2.3e-27, (45.3% identity in 223 aa
overlap); MT2037|MTCY39.35|RV1984C|Q10837|CUT1_MYCTU (217
aa), FASTA scores: opt: 383, E(): 3.4e-16 (42.9% identity
in 217 aa overlap); O69691|Rv3724|MTV025.072 putative
cutinase precursor (187 aa), FASTA scores: opt: 248, E():
4.3e-08, (41.85% identity in 172 aa overlap); etc. Also
similar to few others from other organisms e.g. Q9KK87
serine esterase cutinase from Mycobacterium avium (220
aa),FASTA scores: opt: 391, E(): 1.1e-16, (39.15% identity
in 235 aa overlap); etc. Contains PS00095 C-5
cytosine-specific DNA methylases C-terminal signature.
Belongs to the cutinase family. Start changed since first
submission (+11 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2301"
/db_xref="EnsemblGenomes-Tr:CCP45083"
/db_xref="GOA:P9WP41"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR011150"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WP41"
/inference="protein motif:PROSITE:PS00095"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45083.1"
/translation="MNDLLTRRLLTMGAAAAMLAAVLLLTPITVPAGYPGAVAPATAA
CPDAEVVFARGRFEPPGIGTVGNAFVSALRSKVNKNVGVYAVKYPADNQIDVGANDMS
AHIQSMANSCPNTRLVPGGYSLGAAVTDVVLAVPTQMWGFTNPLPPGSDEHIAAVALF
GNGSQWVGPITNFSPAYNDRTIELCHGDDPVCHPADPNTWEANWPQHLAGAYVSSGMV
NQAADFVAGKLQ"
gene 2573813..2574055
/locus_tag="Rv2302"
CDS 2573813..2574055
/codon_start=1
/transl_table=11
/locus_tag="Rv2302"
/product="Conserved protein"
/note="Rv2302, (MTCY339.07c), len: 80 aa. Conserved
protein, highly similar to others:
O53766|AL021942|Rv0569|MTV039.07 hypothetical 9.5 KDA
protein from Mycobacterium tuberculosis (88 aa), FASTA
scores: opt: 300, E(): 1.4e-14, (61.85% identity in 76 aa
overlap); O88049|SCI35.11 hypothetical 7.1 KDA protein
from Streptomyces coelicolor (64 aa), FASTA scores: opt:
169,E(): 1.5e-05, (46.55% identity in 58 aa overlap) (has
its C-terminus shorter); Q9XCD1 hypothetical 12.0 KDA
protein (fragment) from Thermomonospora fusca (106 aa),
FASTA scores: opt: 126, E(): 0.023, (50.0% identity in 34
aa overlap) (similarity in part for this one). Also weakly
similar to U650M|G699303|Q50105 hypothetical 5.7 KDA
protein from Mycobacterium leprae (53 aa), FASTA scores:
opt: 89, E(): 0.66, (45.5% identity in 33 aa overlap); and
weakly similar to N-terminus of Q9RIZ1|SCJ1.23c putative
DNA-binding protein from Streptomyces coelicolor (323
aa),FASTA scores: opt: 182, E(): 7.3e-06, (42.25% identity
in 71 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2302"
/db_xref="EnsemblGenomes-Tr:CCP45084"
/db_xref="GOA:P9WLD5"
/db_xref="InterPro:IPR015035"
/db_xref="PDB:2A7Y"
/db_xref="UniProtKB/Swiss-Prot:P9WLD5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45084.1"
/translation="MHAKVGDYLVVKGTTTERHDQHAEIIEVRSADGSPPYVVRWLVN
GHETTVYPGSDAVVVTATEHAEAEKRAAARAGHAAT"
gene complement(2574096..2575019)
/locus_tag="Rv2303c"
CDS complement(2574096..2575019)
/codon_start=1
/transl_table=11
/locus_tag="Rv2303c"
/product="Probable antibiotic-resistance protein"
/note="Rv2303c, (MTCY339.06, MT2360), len: 307 aa.
Probable antibiotic-resistance protein, with some
similarity to Q54229|G153373 macrotetrolide
antibiotic-resistance protein (NONR) from Streptomyces
griseus (347 aa) (see Plater and Robinson, 1992), FASTA
scores: opt: 438, E(): 3.1e-21,(33.2% identity in 226 aa
overlap); and other hypothetical proteins e.g. P95886 ORF
C02006 from Sulfolobus solfataricus (269 aa), FASTA
scores: opt: 252, E(): 3.5e-09, (25.5% identity in 286 aa
overlap); etc. Also similar to Mycobacterium tuberculosis
Rv3510c|O53555|MTV023.17. Note that the protein
Q9XDF3|NONC from Streptomyces griseus subsp. griseus (317
aa) is equivalent to Q54229|G153373|NONR however the
N-terminal end is shorter (30 aa) owing to a changed start
codon (see Walczak et al., 2000). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2303c"
/db_xref="EnsemblGenomes-Tr:CCP45085"
/db_xref="GOA:Q50662"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR032465"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/TrEMBL:Q50662"
/protein_id="CCP45085.1"
/translation="MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTK
TTISAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNASVAAV
AARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRPFMIGRPASDPAYFPCY
AKCVELGVPVSIHTSADWTRTRLSDLGHPRHIDDVACRFPELTILMSHGGYPWVLQAC
LIAWKHPNVYLELAAHRPKYFASPGAGWEPLMRFGQTTIRNKIVYGTGGFLINRPYLQ
LCDEMRALPVPREVLEDWLWRNATRVLRLDT"
gene complement(2575016..2575225)
/locus_tag="Rv2304c"
CDS complement(2575016..2575225)
/codon_start=1
/transl_table=11
/locus_tag="Rv2304c"
/product="Hypothetical protein"
/note="Rv2304c, (MTCY339.05), len: 69 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2304c"
/db_xref="EnsemblGenomes-Tr:CCP45086"
/db_xref="UniProtKB/Swiss-Prot:P9WLD3"
/protein_id="CCP45086.1"
/translation="MSHDIATEEADDGALDRCVLCDLTGKRVDVKEATCTGRPATTFE
QAFAVERDAGFDDFLHGPVGPRSTP"
gene 2575809..2577098
/locus_tag="Rv2305"
CDS 2575809..2577098
/codon_start=1
/transl_table=11
/locus_tag="Rv2305"
/product="Unknown protein"
/note="Rv2305, (MTCY339.04c), len: 429 aa. Unknown
protein. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2305"
/db_xref="EnsemblGenomes-Tr:CCP45087"
/db_xref="GOA:P9WLD1"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WLD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45087.1"
/translation="MTQTLRLTALDEMFITDDIDIVPSVQIEARVSGRFDLDRLAAAL
RAAVAKHALARARLGRASLTARTLYWEVPDRADHLAVEITDEPVGEVRSRFYARAPEL
HRSPVFAVAVVRETVGDRLLLNFHHAAFDGMGGLRLLLSLARAYAGEPDEVGGPPIEE
ARNLKGVAGSRDLFDVLIRARGLAKPAIDRKRTTRVAPDGGSPDGPRFVFAPLTIESD
EMATAVARRPEGATVNDLAMAALALTILQWNRTHDVPAADSVSVNMPVNFRPTAWSTE
VISNFASYLAIVLRVDEVTDLEKATAIVAGITGPLKQSGAAGWVVDLLEGGKVLPAML
KRQLQLLLPLVEDRFVESVCLSNLGRVDVPAFGGEAGDTTEVWFSPTAAMSVMPIGVG
LVGFGGTLRAMFRGDGRTIGGEALGRFAALYRDTLLT"
gene 2577108..2577701
/locus_tag="Rv2306A"
CDS 2577108..2577701
/codon_start=1
/transl_table=11
/locus_tag="Rv2306A"
/product="Possible conserved membrane protein"
/note="Rv2306A, len: 197 aa. Possible conserved membrane
protein, similar to several hypothetical membrane proteins
from Mycobacterium tuberculosis and Streptomyces
coelicolor, e.g. Rv0625c|P96915|Y625_MYCTU hypothetical
25.2 KDA protein from Mycobacterium tuberculosis (246
aa),FASTA scores: opt: 410, E(): 2.7e-17, (53.25% identity
in 139 aa overlap). First 140 aa show high similarity,
this then decreases but continues in next ORF
Rv2306B,suggesting a frameshift near nt 2577473. However
the sequence has been checked and no error found. The
sequence is identical in CDC1551 and Mycobacterium bovis.
Replaces original Rv2306c on other strand. This region is
a possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2306A"
/db_xref="EnsemblGenomes-Tr:CCP45088"
/db_xref="GOA:Q79FG5"
/db_xref="UniProtKB/TrEMBL:Q79FG5"
/protein_id="CCP45088.1"
/translation="MTDNECPADSRRRHVLRLALFAGILLGLFYLVAVARVIHVDGVR
SAIVVATGPIAPLAYVVVSAALGALFVPGPILAAGSGVLFGPLLDTFVTLPAFSAGAQ
AGMTPRRCWVSIAPIASMHRSNGADCGRWSVSASSPASRMRWPRTPSGRSEFRCGRWS
LGRSSGRRHGCSSTPRWARRSPTCRRRWFTRRSRCGA"
gene 2577488..2577922
/locus_tag="Rv2306B"
CDS 2577488..2577922
/codon_start=1
/transl_table=11
/locus_tag="Rv2306B"
/product="Possible conserved membrane protein"
/note="Rv2306B, len: 144 aa. Possible conserved membrane
protein, similar to C-terminal part of several
hypothetical membrane proteins from Mycobacterium
tuberculosis and Streptomyces coelicolor e.g.
P96915|Y625_MYCTU|RV0625c hypothetical 25.2 KDA protein
from Mycobacterium tuberculosis (246 aa), FASTA scores:
opt: 480, E(): 5e-24,(77.15% identity in 92 aa overlap).
Could be a continuation of Rv2306A suggesting there may be
a frameshift near nt 2577473. The C-terminal part is
longer than Rv0625c and the 3'-end of gene overlaps
Rv2307c, so maybe a further framehift. However, sequence
has been checked and no error found. Also same sequence as
strain CDC1551 and Mycobacterium bovis. Replaces original
Rv2306c on other strand. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv2306B"
/db_xref="EnsemblGenomes-Tr:CCP45089"
/db_xref="GOA:Q79FG4"
/db_xref="InterPro:IPR015414"
/db_xref="InterPro:IPR032816"
/db_xref="UniProtKB/TrEMBL:Q79FG4"
/protein_id="CCP45089.1"
/translation="MWAVVGQRFVPGISDALASYTFGAFGVPLWQMVVGSFIGSAPRV
FVYTALGASITNLSSPLVYSAIAVWCVTAIIGAFAARRWYRKWRARPRRRCGLAQLTT
GSQQRHTSHRTPAGVVMPGSLSEHRRLRQEAPDRIEHHPPIE"
gene complement(2577851..2578696)
/locus_tag="Rv2307c"
CDS complement(2577851..2578696)
/codon_start=1
/transl_table=11
/locus_tag="Rv2307c"
/product="Conserved hypothetical protein"
/note="Rv2307c, (MTCY339.02), len: 281 aa. Conserved
hypothetical protein, similar to many other hypothetical
proteins and BEM1/BUD5 suppressors e.g. P77538
hypothetical protein from Escherichia coli (293 aa), FASTA
scores: opt: 421, E(): 2.4e-18, (32.1% identity in 268 aa
overlap) (alias AAG57647|Z3802|BAB36823|ECS3400 Putative
enzyme (3.4.-) from Escherichia coli (293 aa), FASTA
scores: opt: 425, E(): 1.7e-18, (32.1% identity in 268 aa
overlap));P54069|BE46_SCHPO|BEM46|SPBC32H8.03|PI020 BEM46
protein from Schizosaccharomyces pombe (Fission yeast)
(352 aa), FASTA scores: opt: 355, E(): 3.3e-14, (30.45%
identity in 279 aa overlap); O76462|BEM46 BEM46 protein
from Drosophila melanogaster (338 aa), FASTA scores: opt:
404,E(): 2.8e-17, (32.75% identity in 281 aa overlap);
etc. Equivalent (but with few differences) to
AAK46650|MT2364 protein from Mycobacterium tuberculosis
strain CDC1551 (281 aa). Predicted to be an outer membrane
protein (See Song et al., 2008). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv2307c"
/db_xref="EnsemblGenomes-Tr:CCP45090"
/db_xref="GOA:P9WLC7"
/db_xref="InterPro:IPR022742"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WLC7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45090.1"
/translation="MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPS
ASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALH
GLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAA
VAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVL
VIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTET
AVLGQ"
gene complement(2579228..2579419)
/locus_tag="Rv2307A"
CDS complement(2579228..2579419)
/codon_start=1
/transl_table=11
/locus_tag="Rv2307A"
/product="Hypothetical glycine rich protein"
/note="Rv2307A, len: 63 aa. Hypothetical unknown protein.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2307A"
/db_xref="EnsemblGenomes-Tr:CCP45091"
/db_xref="UniProtKB/TrEMBL:L7N678"
/protein_id="CCP45091.1"
/translation="MAFVDLRYPWCRGDGWISPPVVAVALGWAMRRKPFSRFNEYVGS
ASNTCWFARALELRTLLIR"
gene complement(2579504..2579935)
/locus_tag="Rv2307B"
CDS complement(2579504..2579935)
/codon_start=1
/transl_table=11
/locus_tag="Rv2307B"
/product="Hypothetical glycine rich protein"
/note="Rv2307B, len: 143 aa. Hypothetical unknown Gly-
rich protein. Equivalent to AAK46653 from Mycobacterium
tuberculosis strain CDC1551 (133 aa) but longer 10 aa.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2307B"
/db_xref="EnsemblGenomes-Tr:CCP45092"
/db_xref="UniProtKB/TrEMBL:Q79FG2"
/protein_id="CCP45092.1"
/translation="MEEVPTGPPAMGHRACGGQKAAFPTRMNSGVEKMYKNSIAIAIG
TLTMAVEFSMVSANAEPAPPPGQDPHMPNSAMGYCPGGGFGGITGWGYCDGIRYPDGS
YWHQVRVPAPFVGTTLTLSCVIDDGSPVPPLAAPGSCGGGA"
gene complement(2580028..2580210)
/locus_tag="Rv2307D"
CDS complement(2580028..2580210)
/codon_start=1
/transl_table=11
/locus_tag="Rv2307D"
/product="Hypothetical protein"
/note="Rv2307D, len: 60 aa. Hypothetical unknown protein.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2307D"
/db_xref="EnsemblGenomes-Tr:CCP45093"
/db_xref="UniProtKB/TrEMBL:L7N683"
/protein_id="CCP45093.1"
/translation="MWRHLWLMQPQRRYPRGSGTTRTARRDAGVAPLYGVSRVTVLAS
TTATTAPPVKSFPDLL"
gene 2580419..2581135
/locus_tag="Rv2308"
CDS 2580419..2581135
/codon_start=1
/transl_table=11
/locus_tag="Rv2308"
/product="Conserved hypothetical protein"
/note="Rv2308, (MTCY339.01c), len: 238 aa. Conserved
hypothetical protein, sharing similarity with
O53464|Rv2018|MTV018.05 from Mycobacterium tuberculosis
(239 aa), FASTA scores: opt: 142, E(): 0.034, (24.8%
identity in 250 aa overlap). As contains possible
helix-turn-helix motif at aa 16-37 (Sequence:
YVYAEVDKLIGLPAGTAKRWIN) (Score 1169, +3.17 SD), may be a
transcriptional regulator. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2308"
/db_xref="EnsemblGenomes-Tr:CCP45094"
/db_xref="GOA:P9WLC5"
/db_xref="InterPro:IPR007367"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR017277"
/db_xref="UniProtKB/Swiss-Prot:P9WLC5"
/protein_id="CCP45094.1"
/translation="MRADMSVTSMLDREVYVYAEVDKLIGLPAGTAKRWINGYERGGK
DHPPILRVTPGATPWVTWGEFVETRMLAEYRDRRKVPIVRQRAAIEELRARFNLRYPL
AHLRPFLSTHERDLTMGGEEIGLPDAEVTIRTGQALLGDARWLASIATPGRDEVGEAV
IVELPVDKAFPEIVINPSRYSGQPTFVGRRVSPVTIAQMVDGGEEREDLAADYGLSLK
QIQDAIDYTKKYRLARLVAA"
gene complement(2581764..2581837)
/gene="metV"
tRNA complement(2581764..2581837)
/gene="metV"
/product="tRNA-Met"
/anticodon=(pos:complement(2581801..2581803),aa:Met,
seq:cat)
/note="codon recognized: AUG; metV, tRNA-Met, anticodon
cat, length = 74. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene complement(2581843..2582298)
/locus_tag="Rv2309c"
CDS complement(2581843..2582298)
/codon_start=1
/transl_table=11
/locus_tag="Rv2309c"
/product="Possible integrase (fragment)"
/note="Rv2309c, (MTCY3G12.25), len: 151 aa. Possible
integrase (fragment), similar to others e.g. Q48908
integrase (fragment) from Mycobacterium paratuberculos
(191 aa), FASTA scores: opt: 279, E(): 3.2e-11, (40.4%
identity in 136 aa overlap); etc. Also similar to others
from Mycobacterium tuberculosis e.g. Rv1055|MTV017.08
integrase (fragment) (78 aa) (72.85% identity in 70 aa
overlap); and Rv1054|MTV017.07 integrase (fragment). Could
belong to the 'phage' integrase family. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2309c"
/db_xref="EnsemblGenomes-Tr:CCP45095"
/db_xref="GOA:P71903"
/db_xref="InterPro:IPR002104"
/db_xref="InterPro:IPR011010"
/db_xref="InterPro:IPR013762"
/db_xref="InterPro:IPR014417"
/db_xref="UniProtKB/TrEMBL:P71903"
/protein_id="CCP45095.1"
/translation="MTGAGIVETTTNRVRHVPVPEPVSERLRDELPTEPNALVFPSYR
GGHLPIEEYRRAFDKGCKAVGIADLVPHGLRHTTASLAISAGANVKVVQRLLGHATAA
MTLDRHGHLLSDDLAGVAGLLVQAIKSAAASLRYSDPDSVAVENISAAS"
gene 2583045..2583332
/locus_tag="Rv2309A"
CDS 2583045..2583332
/codon_start=1
/transl_table=11
/locus_tag="Rv2309A"
/product="Hypothetical protein"
/note="Rv2309A, len: 95 aa. Hypothetical unknown protein.
Equivalent to AAK46663 from Mycobacterium tuberculosis
strain CDC1551 (95 aa) but longer 13 aa. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2309A"
/db_xref="EnsemblGenomes-Tr:CCP45096"
/db_xref="UniProtKB/TrEMBL:L7N666"
/protein_id="CCP45096.1"
/translation="MATSSDDITINRHPPLNCAVNRHDESRRSPLRRGLLANGLRERQ
AGALFERYESQFDSFGYIEKVRYRGSGYRVEDVYARADSGPSAGAELPVGP"
gene 2583435..2583779
/locus_tag="Rv2310"
CDS 2583435..2583779
/codon_start=1
/transl_table=11
/locus_tag="Rv2310"
/product="Possible excisionase"
/note="Rv2310, (MT2372, MTCY3G12.24c), len: 114 aa.
Possible excisionase, showing some similarity to others
e.g. Q9LCU5 putative excisionase from Arthrobacter sp. TM1
(174 aa) FASTA scores: opt: 341, E(): 6.6e-15, (48.2%
identity in 110 aa overlap); O85865 putative excisionase
from Sphingomonas aromaticivorans (152 aa), FASTA scores:
opt: 205, E(): 2.2e-06, (41.25% identity in 80 aa
overlap); etc. Also similar to Rv3750c|O69717 hypothetical
protein from Mycobacterium tuberculosis (130 aa), FASTA
scores: opt: 228, E(): 6.9e-08, (43.9% identity in 82 aa
overlap). Contains possible helix-turn-helix motif at aa
20-41 (Score 2181, +6.62 SD). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2310"
/db_xref="EnsemblGenomes-Tr:CCP45097"
/db_xref="GOA:P9WLC3"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR010093"
/db_xref="InterPro:IPR041657"
/db_xref="UniProtKB/Swiss-Prot:P9WLC3"
/protein_id="CCP45097.1"
/translation="MVAALHAGKAVTIAPQSMTLTTQQAADLLGVSRPTVVRLIKSGE
LAAERIGNRHRLVLDDVLAYREARRQRQYDALAESAMDIDADEDPEVICEQLREARRV
VAARRRTERRRA"
gene 2583884..2584408
/locus_tag="Rv2311"
CDS 2583884..2584408
/codon_start=1
/transl_table=11
/locus_tag="Rv2311"
/product="Conserved hypothetical protein"
/note="Rv2311, (MTCY3G12.23c), len: 174 aa. Conserved
hypothetical protein, with similarity (in part) to
transfer proteins homologous TRAA e.g. Q9EUN8|TRAA
transfer protein homolog TRAA from Corynebacterium
glutamicum (1160 aa),FASTA scores: opt: 221, E(): 2.9e-07,
(36.8% identity in 136 aa overlap); Q9ETQ3|TRAA conjugal
transfer protein (TRAA-like protein) from Corynebacterium
equii (1367 aa),FASTA scores: opt: 188, E(): 5.5e-05, (33%
identity in 106 aa overlap); P55418|TRAA_RHISN|Y4DS
probable conjugal transfer protein from Rhizobium sp.
strain NGR234 (1102 aa), FASTA scores: opt: 145, E():
0.035, (29.08% identity in 141 aa overlap); etc. This
region is a possible MT-complex-specific genomic island
(See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2311"
/db_xref="EnsemblGenomes-Tr:CCP45098"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WLC1"
/protein_id="CCP45098.1"
/translation="MAPTGQAVDVAVREGAGDVGYSVERENLPADDPVRNGNRWRVIA
VDTEHHRIAARRLGDGARAAFSGDYLHEHITHGYAITVHASQGTTAHSTHAVLGDNTS
RATLYVAMTPARESNTAYLCERTAGEGARVDLAGWDLWVSGKAEAMSDEKSASPVWCR
VGARCDHRGKRSCW"
gene 2584486..2584755
/locus_tag="Rv2312"
CDS 2584486..2584755
/codon_start=1
/transl_table=11
/locus_tag="Rv2312"
/product="Hypothetical protein"
/note="Rv2312, (MTCY3G12.22c), len: 89 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2312"
/db_xref="EnsemblGenomes-Tr:CCP45099"
/db_xref="UniProtKB/Swiss-Prot:P9WLB9"
/protein_id="CCP45099.1"
/translation="MMKEIELHLVDAAAPSGEIAIKDLAALATALQELTTRISRDPIN
TPGPGRTKQFMEELSQLASAPGPDIDGGIDLTDDEFQAFLQAARS"
gene complement(2585052..2585906)
/locus_tag="Rv2313c"
CDS complement(2585052..2585906)
/codon_start=1
/transl_table=11
/locus_tag="Rv2313c"
/product="Hypothetical protein"
/note="Rv2313c, (MTCY3G12.21), len: 284 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2313c"
/db_xref="EnsemblGenomes-Tr:CCP45100"
/db_xref="InterPro:IPR029032"
/db_xref="UniProtKB/Swiss-Prot:P9WLB7"
/protein_id="CCP45100.1"
/translation="MPAPVSVRDDLCRLVALSPGDGRIAGLVRQVCARALSLPSLPCE
VAVNEPESPAEAVVAEFAEQFSVDVSAITGEQRSLLWTHLGEDAFGAVVAMYIADFVP
RVRAGLEALGVGKEYLGWVTGPISWDHNTDLSAAVFNGFLPAVARMRALDPVTSELVR
LRGAAQHNCRVCKSLREVSALDAGGSETLYGEIERFDTSVLLDVRAKAALRYADALIW
TPAHLAVDVAVEVRSRFSDDEAVELTFDIMRNASNKVAVSLGADAPRVQQGTERYRIG
LDGQTVFG"
gene complement(2585917..2587290)
/locus_tag="Rv2314c"
CDS complement(2585917..2587290)
/codon_start=1
/transl_table=11
/locus_tag="Rv2314c"
/product="Conserved protein"
/note="Rv2314c, (MTCY3G12.20), len: 457 aa. Conserved
protein, highly similar to Q9RJ51|SCI8.02 hypothetical
protein from Streptomyces coelicolor (464 aa) FASTA
scores: opt: 1485, E(): 5.2e-83, (53.5% identity in 454 aa
overlap); similar to AAK24788|CC2824 TldD/PmbA family
protein from Caulobacter crescentus (441 aa), FASTA
scores: opt: 364, E(): 8.3e-15, (29.8% identity in 460 aa
overlap); and showing similarity with Q9HJZ6|TA0814
hypothetical protein from Thermoplasma acidophilum (430
aa), FASTA scores: opt: 220, E(): 4.7e-06, (21.85%
identity in 348 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2314c"
/db_xref="EnsemblGenomes-Tr:CCP45101"
/db_xref="GOA:P71898"
/db_xref="InterPro:IPR002510"
/db_xref="InterPro:IPR036059"
/db_xref="UniProtKB/TrEMBL:P71898"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45101.1"
/translation="MIEPQHAVNIVLKEAARSGRADETMVLVTEKVEATLRWAGNSMT
TNGVSHSRNVTVISIVRRGDSAFVGSVVSAEVDPSVLPGLVVSSQDAARSAPEAGDAA
PLLADTGEPDDWDAPVPGTGAGVFTGIAGSLSRGFRGADRLYGYAHRSVSTTFLASST
GLRRRYTQPTGAIEINAKRGDASAWVGIGTPDFVEVPIDLMLERLSTRLRWAQRTVEL
PAGRYQTIMPPSTVADMMIYLGWSMAGRGAQEGRTAFSAPGGGTRVGERLTELPLTLF
TDPAAPGLACTPFVAVSNSSETQSVFDNGMEISQVDWIRSGVINALAYPRATAAKFDA
PVAVAADNLIMTGGSADLADMIAGTERGLLLTTLWYIREVDPTTLLLTGLTRDGVYLV
EDGEVSAAVNNFRFNESPLDLLRRATEAGVSEPTLPREWSDWVTRTAMPPLRIPDFHM
SSVSQAQ"
gene complement(2587287..2588804)
/locus_tag="Rv2315c"
CDS complement(2587287..2588804)
/codon_start=1
/transl_table=11
/locus_tag="Rv2315c"
/product="Conserved protein"
/note="Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved
protein, highly similar to Q9S273|SCI28.10 hypothetical
47.1 KDA protein from Streptomyces coelicolor (435
aa),FASTA scores: opt: 1768, E():5.6e-101, (63.2% identity
in 432 overlap); and similar to others e.g.
AAK24787|CC2823 hypothetical protein (TldD/PmbA family)
from Caulobacter crescentus (543 aa), FASTA scores: opt:
876, E():3.1e-46,(42.8% identity in 505 overlap);
O58578|PH0848 hypothetical 54.4 KDA protein from
Pyrococcus horikoshii (481 aa), FASTA scores: opt: 661,
E(): 4.3e-33, (29.95% identity in 484 aa overlap);
Q9UZ95|PAB1547 hypothetical 53.6 KDA protein from
Pyrococcus abyssi (473 aa), FASTA scores: opt: 656, E():
8.6e-33, (29.1% identity in 481 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2315c"
/db_xref="EnsemblGenomes-Tr:CCP45102"
/db_xref="GOA:P71897"
/db_xref="InterPro:IPR002510"
/db_xref="InterPro:IPR035068"
/db_xref="InterPro:IPR036059"
/db_xref="UniProtKB/TrEMBL:P71897"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45102.1"
/translation="MTPNRGIDEDFLDLPRQQLADAALSAAATAGASHADLRVHRIST
EIIQLRDGELETAVISRELGLAVRVIVAGTWGFASHAELAPDVAAATARHAVHVATVL
AALNTERVRLAPEPVYTDAEWVSNYRIDPFGVPASEKIAVLRDYSGRLLDADGIDHVS
ASLNAVKEQTFYADTFGSSITQQRVRLLPCLDAVAVDSAAGNFESMRTLAPPTARGWE
VVAGDEIWNWTDELAQLPSLLAEKVRAPSVMPGPTDLVIDPTNLWLTIHESIGHATEY
DRAIGYEAAYAGTSFATPDKLGTLRYGSPVMNVTADRTAEFGLATVGYDDEGVAAQSW
DLVRDGVFVGYQLDRAFAPRLGEPRSNGCSYADSPHHVPIQRMANISLQPGIEDLSTA
DLIGRVDDGIYIVGDKSWSIDMQRYNFQFTGQRFFRIRGGQLYGQLRDVAYQSSTTDF
WNAMEAVGGPSTWRMGGAINCGKAQPGQVAAVSHGCPSALFRGVNVLNTRTEGGR"
gene 2588838..2589710
/gene="uspA"
/locus_tag="Rv2316"
CDS 2588838..2589710
/codon_start=1
/transl_table=11
/gene="uspA"
/locus_tag="Rv2316"
/product="Probable sugar-transport integral membrane
protein ABC transporter UspA"
/note="Rv2316, (MTCY3G12.18c), len: 290 aa. Probable
uspA,sugar-transport integral membrane protein ABC
transporter (see citation below), most similar to
Q9CBN8|USPA|ML1768 sugar transport integral membrane
protein from Mycobacterium leprae (328 aa), FASTA scores:
opt: 1593,E(): 1.9e-93, (82.35% identity in 289 aa
overlap); and similar to O32940|ML1426|MLCB2052.28
possible sugar transport protein (probable ABC-transport
protein, inner membrane component) from Mycobacterium
leprae (319 aa),FASTA scores: opt: 600, E(): 9.2e-31,
(34.25% identity in 295 aa overlap). Also similar to other
proteins involved in transport e.g. Q9X860|SCE134.05c
putative binding protein dependent transport protein from
Streptomyces coelicolor (327 aa), FASTA scores: opt: 639,
E(): 3.2e-33, (40.45% identity in 272 aa overlap);
Q9K6N9|BH3689 sugar transport system (permease) from
Bacillus halodurans (300 aa), FASTA scores: opt: 590, E():
3.7e-30, (35.65% identity in 289 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2316"
/db_xref="EnsemblGenomes-Tr:CCP45103"
/db_xref="GOA:P71896"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:P71896"
/protein_id="CCP45103.1"
/translation="MRDAPRRRTALAYALLAPSLVGVVAFLLLPILVVVWLSLHRWDL
LGPLRYVGLTNWRSVLTDSGFADSLVVTAVFVAIVVPAQTVLGLLAASLLARRLPGTG
LFRTLYVLPWICAPLAIAVMWRWIVAPTDGAISTVLGHRIEWLTDPGLALPVVSAVVV
WTNVGYVSLFFLAGLMAIPQDIHNAARTDGASAWQRFWRITLPMLRPTMFFVLVTGII
SAAQVFDTVYALTGGGPQGSTDLVAHRIYAEAFGAAAIGRASVMAVVLFVILVGATVV
QHLYFRRRISYELT"
gene 2589697..2590521
/gene="uspB"
/locus_tag="Rv2317"
CDS 2589697..2590521
/codon_start=1
/transl_table=11
/gene="uspB"
/locus_tag="Rv2317"
/product="Probable sugar-transport integral membrane
protein ABC transporter UspB"
/note="Rv2317, (MTC3G12.17c), len: 274 aa. Probable
uspB,sugar-transport integral membrane protein ABC
transporter (see citation below), most similar to
Q9CBN7|USPE|ML1769 sugar transport integral membrane
protein from Mycobacterium leprae (274 aa), FASTA scores:
opt: 1522,E(): 3.4e-89, (85.0% identity in 274 aa
overlap); and similar to O32941|ML1425|MLCB2052.29
probable ABC-transport protein, inner membrane component
from Mycobacterium leprae (283 aa), FASTA scores: opt:
630, E(): 8.4e-33, (36.55% identity in 268 aa overlap).
Also similar to other integral membrane proteins e.g.
P73854|LACG|SLR1723 lactose transport system permease
protein from Synechocystis sp. strain PCC 6803 (270 aa),
FASTA scores: opt: 605, E(): 3.1e-31, (36.0% identity in
264 aa overlap); Q9F3B8|SC5F1.11 putative sugar transport
integral membrane protein from Streptomyces coelicolor
(307 aa), FASTA scores: opt: 582, E(): 9.7e-30, (34.45%
identity in 264 aa overlap); etc. Also similar to
O53483|Rv2039c|MTV018.26c sugar transport protein from
Mycobacterium tuberculosis (280 aa), FASTA scores: opt:
630, E(): 8.3e-89, (37.7% identity in 268 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2317"
/db_xref="EnsemblGenomes-Tr:CCP45104"
/db_xref="GOA:L7N652"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:L7N652"
/protein_id="CCP45104.1"
/translation="MSSPSRVSNTAVYAVLTIGAVITLSPFLLGLLTSFTSAHQFATG
TPLQLPRPPTLANYADIADAGFRRAAVVTALMTAVILLGQLTFSVLAAYAFARLQFRG
RDALFWVYVATLMVPGTVTVVPLYLMMAQLGLRNTFWALVLPFMFGSPYAIFLLREHF
RLIPDDLINAARLDGANTLDVIVHVVIPSSRPVLAALAMITVVSQWNNFMWPLVITSG
HKWRVLTVATADLQSRFNDQWTLVMAATTVAIVPLIALFVTFQRHIVASIVVSGLK"
gene 2590518..2591840
/gene="uspC"
/locus_tag="Rv2318"
CDS 2590518..2591840
/codon_start=1
/transl_table=11
/gene="uspC"
/locus_tag="Rv2318"
/product="Probable periplasmic sugar-binding lipoprotein
UspC"
/note="Rv2318, (MTCY3G12.16c), len: 440 aa. Probable
uspC,sugar-binding lipoprotein component of sugar
transport system (see citation below), most similar to
Q9CBN6|USPC|ML1770 sugar transport periplasmic binding
protein from Mycobacterium leprae (446 aa), FASTA scores:
opt: 2294, E(): 8.1e-135, (74.7% identity in 446 aa
overlap). Also similar to other substrate-binding proteins
e.g. Q9RK89|SCF1.15 putative substrate binding protein
(extracellular) (binding-protein-dependent transport)
(fragment) from Streptomyces coelicolor (221 aa), FASTA
scores: opt: 377, E(): 3e-16, (32.25% identity in 217 aa
overlap); Q9K6N8|BH3690 sugar transport system
(sugar-binding protein) from Bacillus halodurans (420
aa),FASTA scores: opt: 227, E(): 1e-06, (25.00% identity
in 452 aa overlap); etc. Also similar to
O53485|Rv2041c|MTV018.28C lipoprotein component of sugar
transport system from Mycobacterium tuberculosis (439 aa),
FASTA scores: opt: 246, E(): 7e-08, (26.75% identity in
325 aa overlap). Contains a hydrophobic stretch (possible
signal peptide) at N-terminal end."
/db_xref="EnsemblGenomes-Gn:Rv2318"
/db_xref="EnsemblGenomes-Tr:CCP45105"
/db_xref="InterPro:IPR006059"
/db_xref="PDB:5K2X"
/db_xref="PDB:5K2Y"
/db_xref="UniProtKB/TrEMBL:P71894"
/protein_id="CCP45105.1"
/translation="MTRPRQSTLVATALVLVAILLGVTAVLLGLSAEPRGGKIVVTVR
LWDEPIAAAYRQSFAAFTRSHPDIEVRTNLVAYSTYFETLRTDVAGGSADDIFWLSNA
YFAAYADSGRLMKIQTDAADWEPAVVDQFTRSGVLWGVPQLTDAGIAVFYNADLLAAA
GVDPTQVDNLRWSRGDDDTLRPMLARLTVDADGRTANTPGFDARRVRQWGYNAANDPQ
AIYLNYIGSAGGVFQRDGKFAFDNPGAIEAFRYLVGLINDDHVAPPASDTNDNGDFSR
NQFLAGKMALFQSGTYSLAPVARDALFHWGVAMLPAGPAGRVSVTNGIAAAGNSASKH
PDAVRQVLAWMGSTEGNSYLGRHGAAIPAVLSAQPVYFDYWSARGVDVTPFFAVLNGP
RIAAPGGAGFAAGQQALEPYFDEMFLGRGDVTTTLRQAQAAANAATQR"
gene complement(2591848..2592726)
/locus_tag="Rv2319c"
CDS complement(2591848..2592726)
/codon_start=1
/transl_table=11
/locus_tag="Rv2319c"
/product="Universal stress protein family protein"
/note="Rv2319c, (MTCY3G12.15), len: 292 aa. Universal
stress protein family protein."
/db_xref="EnsemblGenomes-Gn:Rv2319c"
/db_xref="EnsemblGenomes-Tr:CCP45106"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="UniProtKB/Swiss-Prot:P9WLB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45106.1"
/translation="MTIVVGYLAGKVGPSALHLAVRVARMHKTSLTVATIVRRHWPTP
SLARVDAEYELWSEQLAAASAREAQRYLRRLADGIEVSYHHRAHRSVSAGLLDVVEEL
EAEVLVLGSFPSGRRARVLIGSTADRLLHSSPVPVAITPRRYRCYTDRLTRLSCGYSA
TSGSVDVVRRCGHLASRYGVPMRVITFAVRGRTMYPPEVGLHAEASVLEAWAAQAREL
LEKLRINGVVSEDVVLQVVTGNGWAQALDAADWQDGEILALGTSPFGDVARVFLGSWS
GKIIRYSPVPVLVLPG"
gene complement(2592723..2594153)
/gene="rocE"
/locus_tag="Rv2320c"
CDS complement(2592723..2594153)
/codon_start=1
/transl_table=11
/gene="rocE"
/locus_tag="Rv2320c"
/product="Probable cationic amino acid transport integral
membrane protein RocE"
/note="Rv2320c, (MTCY3G12.14), len: 476 aa. Probable
rocE,cationic amino acid (especially arginine and
ornithine) transporter (permease), highly similar to other
amino acid transporters e.g. Q9L100|SCL6.16C putative
amino acid transporter from Streptomyces coelicolor (496
aa), FASTA scores: opt: 1485, E(): 9.4e-82, (48.4%
identity in 477 aa overlap); O06479|YFNA putative amino
acid transporter from Bacillus subtilis (462 aa), FASTA
scores: opt: 1271, E(): 6.1e-69, (41.9% identity in 463 aa
overlap); Q9PG94|XF0408 amino acid transporter from
Xylella fastidiosa (509 aa),FASTA scores: opt: 1128, E():
2.5e-60, (39.5% identity in 481 aa overlap); etc. Also
some similarity with Z99108.1|BSUB0005 from Bacillus
subtilis (461 aa), FASTA scores: opt: 1271, E(): 0, (41.9%
identity in 463 aa overlap); and G403170 ethanolamine
permease (488 aa), FASTA scores: opt: 468, E(): 1e-23,
(28.1% identity in 462 aa overlap). Seems to belong to the
APC family."
/db_xref="EnsemblGenomes-Gn:Rv2320c"
/db_xref="EnsemblGenomes-Tr:CCP45107"
/db_xref="GOA:P71892"
/db_xref="InterPro:IPR002293"
/db_xref="UniProtKB/TrEMBL:P71892"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45107.1"
/translation="MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTFQLTMFG
VGATIGTGIFFVLAQAVPEAGPGVIVSFIIAGIAAGLAAICYAELASAVPISGSAYSY
AYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNLFGFQMPHVLSAAPWD
THPGWVNLPAVILIGLCALLLIRGASESARVNAIMVLIKLGVLGMFMIIAFSAYSADH
LKDFVPFGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVY
VLVALAALGTQPWQDFAEQETAGLAIILDNVTHGEWASTILAAGAVVSIFTVTLVTMY
GQTRILFAMGRDGLLPARFAKVNPRTMTPVHNTVIVAIFASTLAAFIPLDSLADMVSI
GTLTAFSVVAVGVIVLRVREPDLPRGFKVPGYPVTPVLSVLACGYILASLHWYTWLAF
SGWVAVAVIFYLMWGRHHSALNEEVP"
gene complement(2594154..2594699)
/gene="rocD2"
/locus_tag="Rv2321c"
CDS complement(2594154..2594699)
/codon_start=1
/transl_table=11
/gene="rocD2"
/locus_tag="Rv2321c"
/product="Probable ornithine aminotransferase (C-terminus
part) RocD2 (ornithine--oxo-acid aminotransferase)"
/note="Rv2321c, (MTCY3G12.13), len: 181 aa. Probable
rocD2,ornithine aminotransferase, highly similar to
C-terminal region of other ornithine aminotransferases,
e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa),
FASTA scores: opt: 628, E(): 1.2e-32, (55.35% identity in
168 aa overlap); P3802|OAT_BACSU|ROCD from Bacillus
subtilis (401 aa), FASTA scores: opt: 477, E(): 4.3e-23,
(42.1% identity in 178 aa overlap); BAB42057|ROCD|SA0818
from Staphylococcus aureus subsp. aureus N315 (396 aa),
FASTA scores: opt: 437, E(): 1.5e-20, (41.3% identity in
170 aa overlap); etc. Contains PS00600 Aminotransferases
class-III pyridoxal-phosphate attachment site. Belongs to
class-III of pyridoxal-phosphate-dependent
aminotransferases. Rv2322c|MTCY3G12.12 (upstream ORF) and
Rv2321c|MTCY3G12.13 appear to be an ornithine
aminotransferase homologue but are frameshifted - we can
find no sequence error in the cosmid to account for this."
/db_xref="EnsemblGenomes-Gn:Rv2321c"
/db_xref="EnsemblGenomes-Tr:CCP45108"
/db_xref="GOA:P71891"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR034757"
/db_xref="UniProtKB/TrEMBL:P71891"
/inference="protein motif:PROSITE:PS00600"
/protein_id="CCP45108.1"
/translation="MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSA
MVADREIFGVVHPGEHGSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLA
DLIGDGAVALRGLGWWADVDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVI
TAQEIDCAVRRFADALWEAGS"
gene complement(2594699..2595364)
/gene="rocD1"
/locus_tag="Rv2322c"
CDS complement(2594699..2595364)
/codon_start=1
/transl_table=11
/gene="rocD1"
/locus_tag="Rv2322c"
/product="Probable ornithine aminotransferase (N-terminus
part) RocD1 (ornithine--oxo-acid aminotransferase)"
/note="Rv2322c, (MTCY3G12.12), len: 221 aa. Probable
rocD1,ornithine aminotransferase, highly similar to
N-terminal region of other ornithine aminotransferases,
e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa),
FASTA scores: opt: 770, E(): 8.7e-40, (55.7% identity in
201 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus
aureus subsp. aureus N315 (396 aa) FASTA scores: opt: 632,
E(): 2.2e-31, (46.1% identity in 208 aa overlap);
P38021|OAT_BACSU|ROCD from Bacillus subtilis (401
aa),FASTA scores: opt: 626, E(): 5.1e-31, (43.1% identity
in 218 aa overlap); etc. Belongs to class-III of
pyridoxal-phosphate-dependent aminotransferases.
Rv2322c|MTCY3G12.12 and Rv2321c|MTCY3G12.13 (upstream ORF)
appear to be an ornithine aminotransferase homologue but
are frameshifted - we can find no sequence error in the
cosmid to account for this."
/db_xref="EnsemblGenomes-Gn:Rv2322c"
/db_xref="EnsemblGenomes-Tr:CCP45109"
/db_xref="GOA:P71890"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR034757"
/db_xref="UniProtKB/TrEMBL:P71890"
/protein_id="CCP45109.1"
/translation="MTNLADATQATMALVERHAAHNYSPLPVVAASAEGAWIADIDGL
RYLDWLAAYSAVNLGHRNPASTATAHAQVDTVTLLNRALHADRLGPLGAALAQLCGKD
VVLPMNSDAEAVESGLRVARKWGADVNGLPAGRHDIILANNNFHGHTSSVVSFSSDPA
AGSGVEPSTPGLRSVPFGDAAAPAQTIDDNTVADLLEPIPGQAGIIVPADDYLPAASS
TTC"
gene complement(2595361..2596269)
/locus_tag="Rv2323c"
CDS complement(2595361..2596269)
/codon_start=1
/transl_table=11
/locus_tag="Rv2323c"
/product="Conserved protein"
/note="Rv2323c, (MTCY3G12.11), len: 302 aa. Conserved
protein, highly similar to others e.g. Q9FC91|2SCG58.22
conserved hypothetical protein from Streptomyces
coelicolor (288 aa), FASTA scores: opt: 561, E(): 7.3e-28,
(46.95% identity in 279 aa overlap); P74535|SLL1336
hypothetical 78.3 KDA protein from Synechocystis sp. (705
aa), FASTA scores: opt: 555, E(): 2.1e-27, (37.75%
identity in 265 aa overlap); etc. Also similar to various
hydrolases e.g. Q53797 beta-hydroxylase
(bleomycin/phleomycin binding protein, ankyrin homologue,
bleomycin and transport protein) from Streptomyces
verticillus (326 aa), FASTA scores: opt: 211, E():
4.5e-06, (26.75% identity in 303 aa overlap);
Q9X7M4|DDAH_STRCO|SC5F2A.01c NG,NG-dimethylarginine
dimethylaminohydrolase (Dimethylargininase)
(Dimethylarginine dimethylaminohydrolase) (258 aa), FASTA
scores: opt: 209,E(): 4.9e-06, (27.15% identity in 243 aa
overlap); G434715 beta-hydroxylase (bleomicin/phleomycin
binding protein) from Streptomyces verticillus (326 aa),
FASTA scores: opt: 211, E(): 4.5e-06, (26.75% identity in
303 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2323c"
/db_xref="EnsemblGenomes-Tr:CCP45110"
/db_xref="GOA:P71889"
/db_xref="UniProtKB/Swiss-Prot:P71889"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45110.1"
/translation="MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRY
AMTPPAFFAVAYAINPWMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPD
MVYTANGGFIAHDIAVVARFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLM
VGERVLAGYGFRTDQRAHAEIAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYP
PAFSTAAQEQLSALFPDAIVVGSADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGF
EPVGVDLSELLKGGGSVKCCTLEIHP"
gene 2596334..2596780
/locus_tag="Rv2324"
CDS 2596334..2596780
/codon_start=1
/transl_table=11
/locus_tag="Rv2324"
/product="Probable transcriptional regulatory protein
(probably AsnC-family)"
/note="Rv2324, (MTCY3G12.10), len: 148 aa. Probable
transcriptional regulatory protein, asnC-family, similar
to other putative AsnC-family regulatory proteins e.g.
Q9L101|SCL6.15C from Streptomyces coelicolor (150 aa)
FASTA scores: opt: 466, E(): 2.4e-24, (52.8% identity in
142 aa overlap); Q9RKY4|SC6D7.14 putative AsnC-family
transcriptional regulatory protein from Streptomyces
coelicolor (165 aa), FASTA scores: opt: 266, E():
5.5e-11,(32.4% identity in 145 aa overlap);
Q9ZEP1|LRPA|SCE94.12c putative transcriptional regulator
from Streptomyces coelicolor (150 aa), FASTA scores: opt:
249, E(): 6.9e-10,(33.35% identity in 147 aa overlap);
etc. Also similar to P96896|Rv3291c|MTCY71.31c from
Mycobacterium tuberculosis (150 aa), FASTA scores: opt:
261, E(): 1.1e-10, (36.4% identity in 143 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2324"
/db_xref="EnsemblGenomes-Tr:CCP45111"
/db_xref="GOA:P71888"
/db_xref="InterPro:IPR000485"
/db_xref="InterPro:IPR011008"
/db_xref="InterPro:IPR019887"
/db_xref="InterPro:IPR019888"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P71888"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45111.1"
/translation="MDRLDDTDERILAELAEHARATFAEIGHKVSLSAPAVKRRVDRM
LESGVIKGFTTVVDRNALGWNTEAYVQIFCHGRIAPDQLRAAWVNIPEVVSAATVTGT
SDAILHVLAHDMRHLEAALERIRSSADVERSESTVVLSNLIDRMPP"
gene complement(2597009..2597857)
/locus_tag="Rv2325c"
CDS complement(2597009..2597857)
/codon_start=1
/transl_table=11
/locus_tag="Rv2325c"
/product="Conserved hypothetical protein"
/note="Rv2325c, (MTCY3G12.09), len: 282 aa. Conserved
hypothetical protein, equivalent to
O32970|MLCB22.37c|ML0849 hypothetical protein from
Mycobacterium leprae (283 aa), FASTA scores: opt:
1405,E(): 1.8e-78, (77.7% identity in 282 aa overlap).
Also some similarity to other proteins e.g.
Q9Z9J1|YBAF|BH0166 YBAF protein (BH0166 protein)
(hypothetical protein) from Bacillus halodurans (265 aa),
FASTA scores: opt: 288, E(): 2.8e-10, (25.8% identity in
264 aa overlap); P70972|YBAF YBAF protein (hypothetical
protein) from Bacillus subtilis (265 aa), FASTA scores:
opt: 259, E(): 1.5e-08, (25.45% identity in 224 aa
overlap); AAK34821|SPY2193|Q99X13 Conserved hypothetical
protein from Streptococcus pyogenes (266 aa), FASTA
scores: opt: 232, E(): 6.5e-07, (25.1% identity in 267 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2325c"
/db_xref="EnsemblGenomes-Tr:CCP45112"
/db_xref="GOA:P9WPI7"
/db_xref="InterPro:IPR003339"
/db_xref="UniProtKB/Swiss-Prot:P9WPI7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45112.1"
/translation="MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVF
GISVLLTFYPGWVTIGMMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAG
GTPVVAVGGVQLGLGGALHFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFR
VLRIPVDEWAVALALALRAFPMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELID
LLAAAITVTLRRADEMGDAITARGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIE
SLILHS"
gene complement(2597854..2599947)
/locus_tag="Rv2326c"
CDS complement(2597854..2599947)
/codon_start=1
/transl_table=11
/locus_tag="Rv2326c"
/product="Possible transmembrane ATP-binding protein ABC
transporter"
/note="Rv2326c, (MTC3G12.08), len: 697 aa. Possible
transmembrane ATP-binding protein ABC transporter (see
citation below). Equivalent to Q9CCF9|ML0848 ABC
transporter from Mycobacterium leprae (724 aa), FASTA
scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697
aa overlap) and also to O32971|MLCB22.38c ABC-type
transporter from Mycobacterium leprae (726 aa), FASTA
scores: opt: 3482, E(): 2.8e-182, (76.9% identity in 697
aa overlap). Similar in part to other ABC transporters
e.g. Q9WY65|TM0222 from Thermotoga maritima (266 aa),
FASTA scores: opt: 407, E(): 4.2e-15, (38.0% identity in
213 aa overlap); etc. Contains 2 X PS00017 ATP/GTP-binding
site motif A (P-loop); and 2 x PS00211 ABC transporters
family signature. Belongs to the ATP-binding transport
protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv2326c"
/db_xref="EnsemblGenomes-Tr:CCP45113"
/db_xref="GOA:P9WQI7"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQI7"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45113.1"
/translation="MCCAVCGPEPGRIGEVTPLGPCPAQHRGGPLRPSELAQASVMAA
LCAVTAIISVVVPFAAGLALLGTVPTGLLAYRYRLRVLAAATVAAGMIAFLIAGLGGF
MGVVHSAYIGGLTGIVKRRGRGTPTVVVSSLIGGFVFGAAMVGMLAAMVRLRHLIFKV
MTANVDGIAATLARMHMQGAAADVKRYFAEGLQYWPWVLLGYFNIGIMIVSLIGWWAL
SRLLERMRGIPDVHKLDPPPGDDVDALIGPVPVRLDKVRFRYPRAGQDALREVSLDVR
AGEHLAIIGANGSGKTTLMLILAGRAPTSGTVDRPGTVGLGKLGGTAVVLQHPESQVL
GTRVADDVVWGLPLGTTADVGRLLSEVGLEALAERDTGSLSGGELQRLALAAALAREP
AMLIADEVTTMVDQQGRDALLAVLSGLTQRHRTALVHITHYDNEADSADRTLSLSDSP
DNTDMVHTAAMPAPVIGVDQPQHAPALELVGVGHEYASGTPWAKTALRDINFVVEQGD
GVLIHGGNGSGKSTLAWIMAGLTIPTTGACLLDGRPTHEQVGAVALSFQAARLQLMRS
RVDLEVASAAGFSASEQDRVAAALTVVGLDPALGARRIDQLSGGQMRRVVLAGLLARA
PRALILDEPLAGLDAASQRGLLRLLEDLRRARGLTVVVVSHDFAGMEELCPRTLHLRD
GVLESAAASEAGGMS"
gene 2599988..2600479
/locus_tag="Rv2327"
CDS 2599988..2600479
/codon_start=1
/transl_table=11
/locus_tag="Rv2327"
/product="Conserved protein"
/note="Rv2327, (MTCY3G12.07c), len: 163 aa. Conserved
protein, similar to Z80775|MTCY21D4.05c|Rv0042c from
Mycobacterium tuberculosis (208 aa), FASTA scores: opt:
242, E(): 5e-08, (43.0% identity in 107 aa overlap). Also
slight similarity to putative transcriptional regulatory
proteins belonging to the MarR-family e.g. Q9CCY2/ML2696
from Mycobacterium leprae (243 aa), FASTA scores: opt:
245,E(): 3.7e-08, (35.35% identity in 150 aa overlap);
Q9L135|SC6D11.20 from Streptomyces coelicolor (155
aa),FASTA scores: opt: 242, E(): 3.9e-08, (34.75% identity
in 141 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2327"
/db_xref="EnsemblGenomes-Tr:CCP45114"
/db_xref="GOA:P71885"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P71885"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45114.1"
/translation="MSPSPAAANRSEVGGPLPGLGADLLAVVARLNRLATQRIQMPLP
AAQARLLATIEAQGEARIGDLAAVDHCSQPTMTTQVRRLEDAGLVTRTADPGDARAVR
IRITPEGIRTLTAVRADRAAAIEPQLALLPPADRRVLADAVDVLRRLLDHAATTPGRA
TRQ"
gene 2600731..2601879
/gene="PE23"
/locus_tag="Rv2328"
CDS 2600731..2601879
/codon_start=1
/transl_table=11
/gene="PE23"
/locus_tag="Rv2328"
/product="PE family protein PE23"
/note="Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of
the Mycobacterium tuberculosis PE family (see citation
below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS
homolog from Mycobacterium marinum (638 aa), FASTA scores:
opt: 495, E(): 6.6e-18, (34.65% identity in 401 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2328"
/db_xref="EnsemblGenomes-Tr:CCP45115"
/db_xref="GOA:P9WIG9"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45115.1"
/translation="MQFLSVIPEQVESAAQDLAGIRSALSASYAAAAGPTTAVVSAAE
DEVSTAIASIFGAYGRQCQVLSAQASAFHDEFVNLLKTGATAYRNTEFANAQSNVLNA
VNAPARSLLGHPSAAESVQNSAPTLGGGHSTVTAGLAAQAGRAVATVEQQAAAAVAPL
PSAGAGLAQVVNGVVTAGQGSAAKLATALQSAAPWLAKSGGEFIVAGQSALTGVALLQ
PAVVGVVQAGGTFLTAGTSAATGLGLLTLAGVEFSQGVGNLALASGTAATGLGLLGSA
GVQLFSPAFLLAVPTALGGVGSLAIAVVQLVQGVQHLSLVVPNVVAGIAALQTAGAQF
AQGVNHTMLAAQLGAPGIAVLQTAGGHFAQGIGHLTTAGNAAVTVLIS"
gene complement(2601914..2603461)
/gene="narK1"
/locus_tag="Rv2329c"
CDS complement(2601914..2603461)
/codon_start=1
/transl_table=11
/gene="narK1"
/locus_tag="Rv2329c"
/product="Probable nitrite extrusion protein 1 NarK1
(nitrite facilitator 1)"
/note="Rv2329c, (MTCY3G12.05), len: 515 aa. Probable
narK1,nitrite extrusion protein, possibly member of major
facilitator superfamily (MFS). Equivalent to
O32974|MLCB22.41c|nark|ML0844 putative nitrite extrusion
protein from Mycobacterium leprae (517 aa), FASTA scores:
opt: 2224, E(): 1.9e-129, (69.3% identity in 488 aa
overlap). Also highly similar to others e.g. P94933
nitrite extrusion protein from Mycobacterium fortuitum
(471 aa),FASTA scores: opt: 1969, E(): 8.6e-114, (62.1%
identity in 459 aa overlap); P37758|NARU_ECOLI nitrite
extrusion protein 2 from Escherichia coli strain K12 (462
aa), FASTA scores: opt: 792, E(): 2.3e-41, (36.95%
identity in 476 aa overlap); P10903|NARK_ECOLI nitrite
extrusion protein (nitrite facilitator 1) from Escherichia
coli strain K12 (463 aa), FASTA scores: opt: 784, E():
7e-41, (35.3% identity in 468 aa overlap); etc. Also
similar to RV0261c|Z86089|MTCY6A4_5 from Mycobacterium
tuberculosis (469 aa), FASTA scores: opt: 2000, E():
1.1e-115, (62.6% identity in 470 aa overlap). Belongs to
the nark/NASA family of transporters."
/db_xref="EnsemblGenomes-Gn:Rv2329c"
/db_xref="EnsemblGenomes-Tr:CCP45116"
/db_xref="GOA:P71883"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:P71883"
/protein_id="CCP45116.1"
/translation="MEQHTLLQREESPRSPAAPSLRRLGGSRHITHWDPEDLGAWEAG
NKGIARRNLLWSVVTVHLGYSVWTLWPVLELLMPQDVYGFSTSDKFLLGTIATLFGAF
LRMPYALASAIFGGRNWATFSAIVLLIPAIGTTVLLTHPGLPLWPYLVCAALTGLGGG
NFASSMSNANAFYPHRLKGSALGIAGGVGNLGVPAIQLVGLLAIATVGERKPYLVCAL
YVVLVAIAVIGVSLFMNNVEQHRVQVNRLRPIVSAVLSTRDTWLLSLLYLGTFGSFIG
FSFVFGQVLQTNFLACGQSPARATLHAVELAFVGPLLAAVARIYGGRLADRVGGSRLT
LIVFVAMTLAAGLLISASTLEGRHVGQHRGATMVGYFVCFVALFVLSGLGNGSVYKMI
PTIFEACSRSLDLSEAERRDWSRIISGVVIGFVAAFGALGGVGINMALRESYLSTGSG
TDAFWIFMMCYAAAAVLTWKVYDRRTVTDMGMLQAALVRQPASTPAELIGPRTQSDRF
SGCSISA"
gene complement(2603695..2604222)
/gene="lppP"
/locus_tag="Rv2330c"
CDS complement(2603695..2604222)
/codon_start=1
/transl_table=11
/gene="lppP"
/locus_tag="Rv2330c"
/product="Probable lipoprotein LppP"
/note="Rv2330c, (MTCY3G12.04), len: 175 aa. Probable
lppP,lipoprotein. Contains signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2330c"
/db_xref="EnsemblGenomes-Tr:CCP45117"
/db_xref="GOA:P9WK69"
/db_xref="InterPro:IPR025971"
/db_xref="UniProtKB/Swiss-Prot:P9WK69"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45117.1"
/translation="MRRQRSAVPILALLALLALLALIVGLGASGCAWKPPTTRPSPPN
TCKDSDGPTADTVRQAIAAVPIVVPGSKWVEITRGHTRNCRLHWVQIIPTIASQSTPQ
QLLFFDRNIPLGSPTRNPKPYITVLPAGDDTVTVQYQWQIGSDQECCPTGIGTVRFHI
GSDGKLEALGSIPHQ"
gene 2604297..2604683
/locus_tag="Rv2331"
CDS 2604297..2604683
/codon_start=1
/transl_table=11
/locus_tag="Rv2331"
/product="Hypothetical protein"
/note="Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa.
Hypothetical unknown protein; shortened version of
MTCY3G12.03c to eliminate overlap with MTCY3G12.04."
/db_xref="EnsemblGenomes-Gn:Rv2331"
/db_xref="EnsemblGenomes-Tr:CCP45118"
/db_xref="UniProtKB/Swiss-Prot:P9WLB3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45118.1"
/translation="MPPVFLPQIGRLTPDAVGEAIGIAADDIPMAARWIGSRPCSLIG
QPNTMGDEMGYLGPGLAGQRCVDRLVMGASRSTCSRLPVIASVDERLSVLKPVRPRLH
SISFIFKGRPGEVYLTVTGYNFRGVP"
gene 2604740..2605078
/locus_tag="Rv2331A"
CDS 2604740..2605078
/codon_start=1
/transl_table=11
/locus_tag="Rv2331A"
/product="Hypothetical protein"
/note="Rv2331A, len: 112 aa. Hypothetical unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv2331A"
/db_xref="EnsemblGenomes-Tr:CCP45119"
/db_xref="UniProtKB/TrEMBL:Q79FF7"
/protein_id="CCP45119.1"
/translation="MKGHLATFGHPALPTYRGSWLSREPGSPYRLPAGAGRDRGDACR
RIPRRTGSGTLLRPGQRCTFAANADPMAKGVDRALCEIVAERRQLDLDLAKAQVRSAL
ANQRYHRDVH"
gene 2605108..2606754
/gene="mez"
/locus_tag="Rv2332"
CDS 2605108..2606754
/codon_start=1
/transl_table=11
/gene="mez"
/locus_tag="Rv2332"
/product="Probable [NAD] dependent malate oxidoreductase
Mez (malic enzyme) (NAD-malic enzyme) (malate
dehydrogenase (oxaloacetate decarboxylating))
(pyruvic-malic carboxylase) (NAD-me)"
/note="Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548
aa. Probable mez, malate oxidoreductase [NAD] dependent
(malic enzyme), highly similar to others e.g. O34389|MALS
putative malolactic enzyme [includes: malic enzyme ;
L-lactate dehydrogenase] from Bacillus subtilis (566
aa),FASTA scores: opt: 1927, E(): 5.5e-111, (52.9%
identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA
probable NAD-dependent malic enzyme from Bacillus subtilis
(582 aa),FASTA scores: opt: 1849, E(): 3.6e-106, (50.45%
identity in 543 aa overlap); Q48796|MLES_OENOE malolactic
enzyme from Oenococcus oeni (541 aa), FASTA scores: opt:
1540, E(): 3.6e-87, (44.2% identity in 536 aa overlap);
etc. Belongs to the malic enzymes family. N-terminus
shortened since first submission (previously 652 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2332"
/db_xref="EnsemblGenomes-Tr:CCP45120"
/db_xref="GOA:P9WK25"
/db_xref="InterPro:IPR001891"
/db_xref="InterPro:IPR012301"
/db_xref="InterPro:IPR012302"
/db_xref="InterPro:IPR015884"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR037062"
/db_xref="UniProtKB/Swiss-Prot:P9WK25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45120.1"
/translation="MSDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLT
LDQQAERVWHQLQSLATELGRNLLLEQLHYRHEVLYFKVLADHLPELMPVVYTPTVGE
AIQRFSDEYRGQRGLFLSIDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGV
GGIQIAVGKLALYTAGGGVDPRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYD
EFVSRYIETAQRLFPRAILHFEDFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAV
YSGLKVTGIPLRDQTIVVFGAGTAGMGIADQIRDAMVADGATLEQAVSQIWPIDRPGL
LFDDMDDLRDFQVPYAKNRHQLGVAVGDRVGLSDAIKIASPTILLGCSTVYGAFTKEV
VEAMTASCKHPMIFPLSNPTSRMEAIPADVLAWSNGRALLATGSPVAPVEFDETTYVI
GQANNVLAFPGIGLGVIVAGARLITRRMLHAAAKAIAHQANPTNPGDSLLPDVQNLRA
ISTTVAEAVYRAAVQDGVASRTHDDVRQAIVDTMWLPAYD"
gene complement(2606708..2608321)
/gene="stp"
/locus_tag="Rv2333c"
CDS complement(2606708..2608321)
/codon_start=1
/transl_table=11
/gene="stp"
/locus_tag="Rv2333c"
/product="Integral membrane drug efflux protein Stp"
/note="Rv2333c, (MTCY3G12.01), len: 537 aa. stp, integral
membrane drug efflux protein (See Ramon-Garcia et
al.,2007), member of major facilitator superfamily
(MFS),highly similar to many e.g. Q9RL22|C5G9.04c putative
transmembrane efflux protein from Streptomyces coelicolor
(489 aa), FASTA scores: opt: 1031, E(): 4e-55, (37.4%
identity in 412 aa overlap); Q9L0L9|SCD82.12 putative
transmembrane efflux protein from Streptomyces coelicolor
(490 aa), FASTA scores: opt: 883, E(): 3.8e-46, (36.35%
identity in 407 aa overlap); Q9ZBW5|SC4B5.03c putative
integral membrane efflux protein from Streptomyces
coelicolor (504 aa), FASTA scores: opt: 899, E():
4.1e-47,(37.4% identity in 415 aa overlap);
P39886|TCMA_STRGA tetracenomycin C resistance and export
protein from Streptomyces glaucescens (538 aa), FASTA
scores: opt: 839,E(): 1.9e-43, (32.3% identity in 489 aa
overlap); etc. Also highly similar to
Rv2459|O53186|MTV008.15 probable conserved integral
membrane transport protein from Mycobacterium tuberculosis
strain H37Rv (508 aa), FASTA scores: opt: 1385, E():
1.5e-76, (44.05% identity in 504 aa overlap); and
AAK46834|MT2534 drug transporter from Mycobacterium
tuberculosis strain CDC1551 (523 aa), FASTA scores: opt:
1385, E(): 1.5e-76, (44.4% identity in 504 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2333c"
/db_xref="EnsemblGenomes-Tr:CCP45121"
/db_xref="GOA:P9WG91"
/db_xref="InterPro:IPR004638"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WG91"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45121.1"
/translation="MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGL
QWVVASYSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTTAR
GAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPTLGGLLVDQWG
WRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQLLFIVAVGALVYAVIEGPQ
IGWTSVQTIVMLWTAAVGCALFVWLERRSSNPMMDLTLFRDTSYALAIATICTVFFAV
YGMLLLTTQFLQNVRGYTPSVTGLMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLC
MLMLGLLMLIFSEHRSSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIM
SAQRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSANPRAHV
GGIVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWRWFPRDVHTAGSD
LSERLPTAMTVECAVSHMPGATWCRLWPA"
gene 2608796..2609728
/gene="cysK1"
/gene_synonym="cysK"
/locus_tag="Rv2334"
CDS 2608796..2609728
/codon_start=1
/transl_table=11
/gene="cysK1"
/gene_synonym="cysK"
/locus_tag="Rv2334"
/product="Cysteine synthase a CysK1 (O-acetylserine
sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE
A)"
/note="Rv2334, (MT2397, MTCY98.03), len: 310 aa.
cysK1,cysteine synthase A, equivalent to
O32978|CYSK_MYCLE|ML0839|MLCB22.47 cysteine synthase a
from Mycobacterium leprae (310 aa), FASTA scores: opt:
1756,E(): 8.6e-96, (85.8% identity in 310 aa overlap).
Also highly similar to other cysteine synthases e.g.
Q9JQL6|CYSK|NMA0974|NMB0763 putative cysteine synthase
from Neisseria meningitidis (serogroup a and B) (310 aa),
FASTA scores: opt: 1368, E(): 4.6e-73, (66.45% identity in
310 aa overlap); P73410|CYSK_SYNY3|SLR1842 from
Synechocystis sp (312 aa), FASTA scores: opt: 1310, E():
1.2e-69, (64.65% identity in 311 aa overlap);
Q43725|CYSM_ARATH|OASC|ACS1|AT3G59760|F24G16.30 cysteine
synthase (mitochondrial precursor) from Arabidopsis
thaliana (Mouse-ear cress) (424 aa), FASTA scores: opt:
1253, E(): 3.2e-66, (59.2% identity in 309 aa overlap)
(has its N-terminus longer 104 aa); etc. Contains PS00901
Cysteine synthase/cystathionine beta-synthase P-phosphate
attachment site. Belongs to the cysteine
synthase/cystathionine beta-synthase family. Note that
previously known as cysK."
/db_xref="EnsemblGenomes-Gn:Rv2334"
/db_xref="EnsemblGenomes-Tr:CCP45122"
/db_xref="GOA:P9WP55"
/db_xref="InterPro:IPR001216"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR005856"
/db_xref="InterPro:IPR005859"
/db_xref="InterPro:IPR036052"
/db_xref="PDB:2Q3B"
/db_xref="PDB:2Q3C"
/db_xref="PDB:2Q3D"
/db_xref="PDB:3ZEI"
/db_xref="UniProtKB/Swiss-Prot:P9WP55"
/inference="protein motif:PROSITE:PS00901"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45122.1"
/translation="MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVK
DRIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSLER
RMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPANPAIHRVTTAE
EVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVLSGGQKGPH
PIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQ
VARRPENAGKLIVVVLPDFGERYLSTPLFADVAD"
gene 2609732..2610421
/gene="cysE"
/locus_tag="Rv2335"
CDS 2609732..2610421
/codon_start=1
/transl_table=11
/gene="cysE"
/locus_tag="Rv2335"
/product="Probable serine acetyltransferase CysE (sat)"
/note="Rv2335, (MTCY98.04), len: 229 aa. Probable
cysE,serine acetyltransferase, equivalent to
O32979|CYSE|ML0838 serine acetyltransferase from
Mycobacterium leprae (227 aa), FASTA scores: opt: 1152,
E(): 9.6e-62, (76.4% identity in 229 aa overlap). Also
highly similar, except in C-terminal part, to others e.g.
Q9HXI6|CYSE|PA3816 O-acetylserine synthase from
Pseudomonas aeruginosa (258 aa), FASTA scores: opt: 737,
E(): 6e-37, (61.3% identity in 168 aa overlap);
P23145|NIFP_AZOCH probable serine acetyltransferase from
Azotobacter chroococcum mcd 1 (269 aa), FASTA scores: opt:
718, E(): 8.4e-36, (55.45% identity in 220 aa overlap);
Q06750|CYSE_BACSU serine acetyltransferase from Bacillus
subtilis (217 aa), FASTA scores: opt: 640, E(): 3.1e-31,
(48.0% identity in 200 aa overlap); etc. Contains PS00101
Bacterial hexapeptide-repeat containing-transferases
signature. Belongs to the CYSE/LACA/LPXA/NODL family of
acetyltransferases. Composed of multiple repeats of
[LIV]-G-X(4)."
/db_xref="EnsemblGenomes-Gn:Rv2335"
/db_xref="EnsemblGenomes-Tr:CCP45123"
/db_xref="GOA:P95231"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR005881"
/db_xref="InterPro:IPR011004"
/db_xref="InterPro:IPR018357"
/db_xref="InterPro:IPR042122"
/db_xref="UniProtKB/Swiss-Prot:P95231"
/inference="protein motif:PROSITE:PS00101"
/protein_id="CCP45123.1"
/translation="MLTAMRGDIRAARERDPAAPTALEVIFCYPGVHAVWGHRLAHWL
WQRGARLLARAAAEFTRILTGVDIHPGAVIGARVFIDHATGVVIGETAEVGDDVTIYH
GVTLGGSGMVGGKRHPTVGDRVIIGAGAKVLGPIKIGEDSRIGANAVVVKPVPPSAVV
VGVPGQVIGQSQPSPGGPFDWRLPDLVGASLDSLLTRVARLEALGGGPQAAGVIRPPE
AGIWHGEDFSI"
gene 2610837..2611805
/locus_tag="Rv2336"
CDS 2610837..2611805
/codon_start=1
/transl_table=11
/locus_tag="Rv2336"
/product="Hypothetical protein"
/note="Rv2336, (MTCY98.05), len: 322 aa. Hypothetical
unknown protein (see Rindi et al., 2001). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2336"
/db_xref="EnsemblGenomes-Tr:CCP45124"
/db_xref="GOA:P95232"
/db_xref="UniProtKB/TrEMBL:P95232"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45124.1"
/translation="MDVPHEQPALSSSKSNRFTSQRQTTGVGTTTVERLEPRLSPASR
HITEAKAFGTECHVSSFTREQDPDRAVRVEQIHGEAYVAAGHVYESALDELGRLDNSN
AEFILDKARGSTRETEVIYLHAVPAEPLSGSQGEGGLRIVGISAVGSIDDLSAFKAAK
PSMGLAHQRKLYDAIEDLGHGGVKEIAALSVTADAPPTVSYSLIREVLRLYHRTGEKL
IITFAMPAYAKMVMNFGRFAMPQVGEPFYAHRNNDPRTSNDLLLVPSIVEPSNFLENI
SRGVVTADDGPTARRRFATLCYMTDGLDDYFMPLTRQVLSEGIQDI"
gene complement(2611869..2612987)
/locus_tag="Rv2337c"
CDS complement(2611869..2612987)
/codon_start=1
/transl_table=11
/locus_tag="Rv2337c"
/product="Hypothetical protein"
/note="Rv2337c, (MTCY98.06c), len: 372 aa. Hypothetical
unknown protein, sharing some similarity with
Q9RI33|SCJ12.27c hypothetical 37.2 KDA protein from
Streptomyces coelicolor (335 aa), blast scores: 134 and
46,(28% and 33% identity, 52% and 44% positive); FASTA
scores: opt: 176, E(): 0.00042, (31.95% identity in 355 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2337c"
/db_xref="EnsemblGenomes-Tr:CCP45125"
/db_xref="GOA:P95233"
/db_xref="InterPro:IPR000415"
/db_xref="UniProtKB/TrEMBL:P95233"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45125.1"
/translation="MRAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGR
RVRLWGDQTWRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVCWFPDSGNPGLVA
EIDVDRLPQTRVDPIEGAIERRRTNRRVRFRGPPLSQGELGALSAEATGIDGIQLHWF
DSPETRKQILRLVRLAETERFRSRELHEELFSAVRFDIGWTASSDDGLPPGSLEVEAW
MRPMFRGLRHWRVLRLLRTVGMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAG
AVFERIWLRTTLLGAELQPFAASAVLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMV
FRIGHARAPSVRTMRQSVEAYCYAPAERSGSDSESRFA"
gene complement(2613107..2614063)
/gene="moeW"
/locus_tag="Rv2338c"
CDS complement(2613107..2614063)
/codon_start=1
/transl_table=11
/gene="moeW"
/locus_tag="Rv2338c"
/product="Possible molybdopterin biosynthesis protein
MoeW"
/note="Rv2338c, (MTCY98.07c), len: 318 aa. Possible
moeW,molybdoptenum biosynthesis protein, showing some
similarity to several molybdopterin biosynthesis proteins
e.g. O27613|MTH1571 molybdopterin biosynthesis protein
MOEB homolog from Methanobacterium thermoautotrophicum
(251 aa),FASTA scores: opt: 309, E(): 4.7e-14; (30.7%
identity in 254 aa overlap); Q9KPQ5|VC2311 HESA/MOEB/THIF
family protein from Vibrio cholerae (273 aa), FASTA
scores: opt: 255, E(): 4e-09, (36.25% identity in 149 aa
overlap); Q9PD34|XF1545 molybdopterin biosynthesis protein
from Xylella fastidiosa (276 aa), FASTA scores: opt:
233,E(): 1e-07, (33.6% identity in 128 aa overlap); etc.
Seems to belong to the HESA/MOEB/THIF family. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2338c"
/db_xref="EnsemblGenomes-Tr:CCP45126"
/db_xref="GOA:P95234"
/db_xref="InterPro:IPR000594"
/db_xref="InterPro:IPR035985"
/db_xref="UniProtKB/TrEMBL:P95234"
/protein_id="CCP45126.1"
/translation="MRAGADAPDSGRVKESAPWSYDEAFCRNLGLISPTEQQRLRNSR
VAIAGMGGVGGIDMVALARMGIGKFTIADPDVFEIRNSNRQYGAMRSTNGQAKAEVMR
NIVHDINPEAEIRAFCEPIGKENAATFLEGADVLVDGIDAFEIDLRRLLYREAQQRGI
YALGAGPLGFSTAWVVFDPKGMTFDRYFDLSDAMNTVDKFVAFIAGIAPSATHRRSID
LSYVDIENRTGPSVGLACHLASGVVAAEVLKILLGHGRVYAAPYFHQFDAYRSIYVRK
RLRCGNRHPLQRVKRRLLARYINRRSAGVIPGLRYHRTEPSY"
gene 2614693..2617581
/gene="mmpL9"
/locus_tag="Rv2339"
CDS 2614693..2617581
/codon_start=1
/transl_table=11
/gene="mmpL9"
/locus_tag="Rv2339"
/product="Probable conserved transmembrane transport
protein MmpL9"
/note="Rv2339, (MTCY98.08), len: 962 aa. Probable
mmpL9,conserved transmembrane transport protein (see
citation below), with strong similarity to other
Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE
hypothetical 105.2 kDa protein from Mycobacterium leprae
(959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity
in 937 aa overlap); G699237|U1740AB from Mycobacterium
leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from
Mycobacterium tuberculosis. Belongs to the MmpL family.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2339"
/db_xref="EnsemblGenomes-Tr:CCP45127"
/db_xref="GOA:P9WJU3"
/db_xref="InterPro:IPR004707"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJU3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45127.1"
/translation="MVPGEVHMSDTPSGPHPIIPRTIRLAAIPILLCWLGFTVFVSVA
VPPLEAIGETRAVAVAPDDAQSMRAMRRAGKVFNEFDSNSIAMVVLESDQPLGEKAHR
YYDHLVDTLVLDQSHIQHIQDFWRDPLTAAGAVSADGKAAYVQLYLAGNMGEALANES
VEAVRKIVANSTPPEGIRTYVTGPAALFADQIAAGDRSMKLITGLTFAVITVLLLLVY
RSIATTLLILPMVFIGLGATRGTIAFLGYHGMVGLSTFVVNILTALAIAAGTDYAIFL
VGRYQEARHIGQNREASFYTMYRGTANVILGSGLTIAGATYCLSFARLTLFHTMGPPL
AIGMLVSVAAALTLAPAIIAIAGRFGLLDPKRRLKTRGWRRVGTAVVRWPGPILATSV
ALALVGLLALPGYRPGYNDRYYLRAGTPVNRGYAAADRHFGPARMNPEMLLVESDQDM
RNPAGMLVIDKIAKEVLHVSGVERVQAITRPQGVPLEHASIPFQISMMGATQTMSLPY
MRERMADMLTMSDEMLVAINSMEQMLDLVQQLNDVTHEMAATTREIKATTSELRDHLA
DIDDFVRPLRSYFYWEHHCFDIPLCSATRSLFDTLDGVDTLTDQLRALTDDMNKMEAL
TPQFLALLPPMITTMKTMRTMMLTMRSTISGVQDQMADMQDHATAMGQAFDTAKSGDS
FYLPPEAFDNAEFQQGMKLFLSPNGKAVRFVISHESDPASTEGIDRIEAIRAATKDAI
KATPLQGAKIYIGGTAATYQDIRDGTKYDILIVGIAAVCLVFIVMLMITQSLIASLVI
VGTVLLSLGTAFGLSVLIWQHFVGLQVHWTIVAMSVIVLLAVGSDYNLLLVSRFKEEV
GAGLKTGIIRAMAGTGAVVTSAGLVFAFTMASMAVSELRVIGQVGTTIGLGLLFDTLV
VRSFMTPSIAALLGRWFWWPNMIHSRPTVPEAHTRQGARRIQPHLHRG"
gene complement(2617667..2618908)
/gene="PE_PGRS39"
/locus_tag="Rv2340c"
CDS complement(2617667..2618908)
/codon_start=1
/transl_table=11
/gene="PE_PGRS39"
/locus_tag="Rv2340c"
/product="PE-PGRS family protein PE_PGRS39"
/note="Rv2340c, (MTCY98.09c), len: 413 aa.
PE_PGRS39,Member of the Mycobacterium tuberculosis
PE_family, PGRS subfamily of gly-rich proteins (see
citations below),similar to others eg
YI18_MYCTU|Q50615|Rv1818c|MTCY1A11.25 PE-PGRS family
protein from Mycobacterium tuberculosis (498 aa), FASTA
scores: opt: 710, E(): 1.4e-22, (41.0% identity in 368 aa
overlap); O53884|Rv0872v|MTV043.65c PGRS-family protein
from Mycobacterium tuberculosis (606 aa), FASTA scores:
opt: 708, E(): 1.9e-22, (42.4% identity in 389 aa
overlap); etc. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2340c"
/db_xref="EnsemblGenomes-Tr:CCP45128"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N659"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45128.1"
/translation="MSHVTAAPNVLAASAGELAAIGSTMRAANAAAAAPTAGVLAAGG
DDVSAGIAALFGARAQAYQAISAQAALFHDRFVQILQEGAAAYAMAEAANALPLQKAQ
GVVSELAQDRTGGTGTGQSRGAGGFGGVGQAGGKGWDGGPIGNGQVGEQHGAGQLGST
DGNPGVAGAAHGSGVSASHGSGATGAAGVADPGGSGAGVGSAAGNGTGAGSADAVGGA
GTGRDIVGSVRGDGGVGMASGDGGLSTGAAGASAEGGLMPGFGGAPWVGGHWGLGGEG
HSGAIGGVGEQVAPAVATAPAVSPATTSAVAAESGSTPATKAQAMHATTNPGNAAHQG
NPADPGNSARRADGGRDEQLLLLPLTSLRGLRHTLKKLSGLRARNGLLTASGDNASGS
GRPWDRDQLLRALGLRPPGHE"
gene complement(2619407..2619479)
/gene="asnT"
tRNA complement(2619407..2619479)
/gene="asnT"
/product="tRNA-Asn"
/anticodon=(pos:complement(2619444..2619446),aa:Asn,
seq:gtt)
/note="codon recognized: AAC; asnT, tRNA-Asn, anticodon
gtt, length = 73"
gene 2619597..2620016
/gene="lppQ"
/locus_tag="Rv2341"
CDS 2619597..2620016
/codon_start=1
/transl_table=11
/gene="lppQ"
/locus_tag="Rv2341"
/product="Probable conserved lipoprotein LppQ"
/note="Rv2341, (MTCY98.10), len: 139 aa. Probable
lppQ,conserved lipoprotein, showing some similarity with
Rv1228|O33224|LPQX|MTCI61.11 from Mycobacterium
tuberculosis (185 aa), FASTA scores: opt: 155; E():
0.0073; (31.9% identity in 116 aa overlap). Also shows few
similarity with P29228|VLPA_MYCHR variant surface antigen
a precursor from Mycoplasma hyorhinis (157 aa), FASTA
scores: opt: 96, E(): 7.3, (23.1% identity in 143 aa
overlap). Contains PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2341"
/db_xref="EnsemblGenomes-Tr:CCP45129"
/db_xref="UniProtKB/TrEMBL:P95237"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP45129.1"
/translation="MPVGGRQHVFEKLASILGLVAAPLMLLGLSACGRSAGKTSEPTC
PTEPIDAADSSTTPDPSCVVRATEINGNGSRIQTWTGSYDAAATQSGGVCGGTCNFHA
TVRFTVDEGQISGSVDQVYQAAMVAIATRPTSPSLAP"
gene 2620272..2620529
/locus_tag="Rv2342"
CDS 2620272..2620529
/codon_start=1
/transl_table=11
/locus_tag="Rv2342"
/product="Conserved hypothetical protein"
/note="Rv2342, (MTCY98.11), len: 85 aa. Conserved
hypothetical protein, highly similar to Q9CCG1|ML0834
hypothetical protein from Mycobacterium leprae (100
aa),FASTA scores: opt: 392, E(): 2.9e-20, (78.2% identity
in 78 aa overlap). N-terminus highly similar to N-terminal
part of Q9L085|SCC24.32 putative secreted protein from
Streptomyces coelicolor (108 aa), FASTA scores: opt:
122,E(): 0.077, (39.15% identity in 46 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2342"
/db_xref="EnsemblGenomes-Tr:CCP45130"
/db_xref="UniProtKB/TrEMBL:P95238"
/protein_id="CCP45130.1"
/translation="MIGYVAVLGLGYVLGAKAGRRRYEQIASTYRALTGSPVARSMIE
GGRRKIANRISPDAGFVTLAEIDNQTAVVQRGVERQPKTAR"
gene complement(2620533..2622452)
/gene="dnaG"
/locus_tag="Rv2343c"
CDS complement(2620533..2622452)
/codon_start=1
/transl_table=11
/gene="dnaG"
/locus_tag="Rv2343c"
/product="Probable DNA primase DnaG"
/note="Rv2343c, (MTCY98.12c), len: 639 aa. Probable
dnaG,DNA primase, equivalent to O52200|PRIM_MYCSM|DNAG DNA
primase from Mycobacterium smegmatis (636 aa), FASTA
scores: opt: 3504, E(): 5.5e-202, (81.55% identity in 639
aa overlap); and Q9CCG2|DNAG|ML0833 DNA primase from
Mycobacterium leprae (642 aa), FASTA scores: opt:
3443,E(): 2.5e-198, (80.4% identity in 642 aa overlap).
Also highly similar to many DNA primases e.g.
Q9S1N4|PRIM_STRCO|DNAG|SC7A8.07c from Streptomyces
coelicolor (641 aa), FASTA scores: opt: 1899, E():
5.1e-106, (47.9% identity in 643 aa overlap);
P74893|PRIM_SYNP7|DNAG from Synechococcus sp. strain PCC
7942 (Anacystis nidulans R2) (616 aa), FASTA scores: opt:
860, E(): 6.6e-44, (35.3% identity in 513 aa overlap);
P05096|PRIM_BACSU from Bacillus subtilis (603 aa) FASTA
scores: opt: 800, E(): 2.5e-40, (33.7% identity in 430 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2343c"
/db_xref="EnsemblGenomes-Tr:CCP45131"
/db_xref="GOA:P9WNW1"
/db_xref="InterPro:IPR002694"
/db_xref="InterPro:IPR006171"
/db_xref="InterPro:IPR006295"
/db_xref="InterPro:IPR013173"
/db_xref="InterPro:IPR013264"
/db_xref="InterPro:IPR019475"
/db_xref="InterPro:IPR030846"
/db_xref="InterPro:IPR034151"
/db_xref="InterPro:IPR036977"
/db_xref="InterPro:IPR037068"
/db_xref="PDB:5W33"
/db_xref="PDB:5W34"
/db_xref="PDB:5W35"
/db_xref="PDB:5W36"
/db_xref="UniProtKB/Swiss-Prot:P9WNW1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45131.1"
/translation="MSGRISDRDIAAIREGARIEDVVGDYVQLRRAGADSLKGLCPFH
NEKSPSFHVRPNHGHFHCFGCGEGGDVYAFIQKIEHVSFVEAVELLADRIGHTISYTG
AATSVQRDRGSRSRLLAANAAAAAFYAQALQSDEAAPARQYLTERSFDAAAARKFGCG
FAPSGWDSLTKHLQRKGFEFEELEAAGLSRQGRHGPMDRFHRRLLWPIRTSAGEVVGF
GARRLFDDDAMEAKYVNTPETLLYKKSSVMFGIDLAKRDIAKGHQAVVVEGYTDVMAM
HLAGVTTAVASCGTAFGGEHLAMLRRLMMDDSFFRGELIYVFDGDEAGRAAALKAFDG
EQKLAGQSFVAVAPDGMDPCDLRLKCGDAALRDLVARRTPLFEFAIRAAIAEMDLDSA
EGRVAALRRCVPMVGQIKDPTLRDEYARQLAGWVGWADVAQVIGRVRGEAKRTKHPRL
GRLGSTTIARAAQRPTAGPPTELAVRPDPRDPTLWPQREALKSALQYPALAGPVFDAL
TVEGFTHPEYAAVRAAIDTAGGTSAGLSGAQWLDMVRQQTTSTVTSALISELGVEAIQ
VDDDKLPRYIAGVLARLQEVWLGRQIAEVKSKLQRMSPIEQGDEYHALFGDLVAMEAY
RRSLLEQASGDDLTA"
gene complement(2622457..2623752)
/gene="dgt"
/locus_tag="Rv2344c"
CDS complement(2622457..2623752)
/codon_start=1
/transl_table=11
/gene="dgt"
/locus_tag="Rv2344c"
/product="Probable deoxyguanosine triphosphate
triphosphohydrolase Dgt (dGTPase) (dGTP
triphosphohydrolase)"
/note="Rv2344c, (MT2409, MTCY98.13c), len: 431 aa.
Probable dgt, deoxyguanosine triphosphate
triphosphohydrolase,equivalent to Q9CCG3|DGT|ML0831
putative deoxyguanosine triphosphate triphosphohydrolase
from Mycobacterium leprae (429 aa), FASTA scores: opt:
2316, E(): 1.6e-137, (83.85% identity in 421 aa overlap);
and O52199|DGTP_MYCSM|AF027507_2
deoxyguanosinetriphosphate triphosphohydrolase from
Mycobacterium smegmatis (428 aa),FASTA scores: opt: 1991,
E(): 3.4e-117, (73.5% identity in 422 aa overlap). Also
highly similar or similar to several deoxyguanosine
triphosphate hydrolases e.g. Q9L2E9|SC7A8.09c putative
deoxyguanosinetriphosphate triphosphohydrolase from
Streptomyces coelicolor (424 aa),FASTA scores: opt: 1216,
E(): 1e-68, (51.05% identity in 425 aa overlap);
BAB48544|MLL1093 dGTP triphosphohydrolase from Rhizobium
loti (Mesorhizobium loti) (404 aa), FASTA scores: opt:
489, E(): 3.1e-23, (33.85% identity in 387 aa overlap);
P15723|DGTP_ECOLI|DGT|B0160 from Escherichia coli strain
K12 (504 aa), FASTA scores: opt: 173, E(): 0.0022,(31.65%
identity in 259 aa overlap); etc. Belongs to the dGTPase
family."
/db_xref="EnsemblGenomes-Gn:Rv2344c"
/db_xref="EnsemblGenomes-Tr:CCP45132"
/db_xref="GOA:P9WNY7"
/db_xref="InterPro:IPR003607"
/db_xref="InterPro:IPR006261"
/db_xref="InterPro:IPR006674"
/db_xref="InterPro:IPR023023"
/db_xref="InterPro:IPR026875"
/db_xref="UniProtKB/Swiss-Prot:P9WNY7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45132.1"
/translation="MSASEHDPYDDFDRQRRVAEAPKTAGLPGTEGQYRSDFARDRAR
VLHSAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGMAIGLGCDLDLVELAGL
AHDIGHPPYGHNGERALDEVAASHGGFEGNAQNFRILTSLEPKVVDAQGLSAGLNLTR
ASLDAVTKYPWMRGDGLGSQRRKFGFYDDDRESAVWVRQGAPPERACLEAQVMDWADD
VAYSVHDVEDGVVSERIDLRVLAAEEDAAALARLGEREFSRVSADELMAAARRLSRLP
VVAAVGKYDATLSASVALKRLTSELVGRFASAAIATTRAAAGPGPLVRFRADLQVPDL
VRAEVAVLKILALQFIMSDPRHLETQARQRERIHRVAHRLYSGAPQTLDPVYAAAFNT
AADDAARLRVVVDQIASYTEGRLERIDADQLGVSRNALD"
gene 2623821..2625803
/locus_tag="Rv2345"
CDS 2623821..2625803
/codon_start=1
/transl_table=11
/locus_tag="Rv2345"
/product="Possible conserved transmembrane protein"
/note="Rv2345, (MTCY98.14), len: 660 aa. Possible
conserved transmembrane protein, with hydrophobic stretch
at N-terminal end around position 180. Similar to O52198
hypothetical 21.2 KDA protein (fragment) from
Mycobacterium smegmatis (195 aa), FASTA scores: opt: 589,
E(): 1.5e-23; (47.2% identity in 195 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2345"
/db_xref="EnsemblGenomes-Tr:CCP45133"
/db_xref="GOA:P9WFJ5"
/db_xref="InterPro:IPR007621"
/db_xref="UniProtKB/Swiss-Prot:P9WFJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45133.1"
/translation="MRLVRLLGMVLTILAAGLLLGPPAGAQPPFRLSNYVTDNAGVLT
SSGRTAVTAAVDRLYADRRIRLWVVYVENFSGQSALNWAQRTTRTSELGNYDALLAVA
TTGREYAFLVPSAMPGVSEGQVDNVRRYQIEPALHDGDYSGAAVAAANGLNRSPSSSS
RVVLLVTVGIIVIVVAVLLVVMRHRNRRRRADELAAARRVDPTNVMALAAVPLQALDD
LSRSMVVDVDNAVRTSTNELALAIEEFGERRTAPFTQAVNNAKAALSQAFTVRQQLDD
NTPETPAQRRELLTRVIVSAAHADRELASQTEAFEKLRDLVINAPARLDLLTQQYVEL
TTRIGPTQQRLAELHTEFDAAAMTSIAGNVTTATERLAFADRNISAARDLADQAVSGR
QAGLVDAVRAAESALGQARALLDAVDSAATDIRHAVASLPAVVADIQTGIKRANQHLQ
QAQQPQTGRTGDLIAARDAAARALDRARGAADPLTAFDQLTKVDADLDRLLATLAEEQ
ATADRLNRSLEQALFTAESRVRAVSEYIDTRRGSIGPEARTRLAEAKRQLEAAHDRKS
SNPTEAIAYANAASTLAAHAQSLANADVQSAQRAYTRRGGNNAGAILGGIIIGDLLSG
GTRGGLGGWIPTSFGGSSNAPGSSPDGGFLGGGGRF"
gene complement(2625888..2626172)
/gene="esxO"
/gene_synonym="ES6_6"
/gene_synonym="Mtb9.9E"
/locus_tag="Rv2346c"
CDS complement(2625888..2626172)
/codon_start=1
/transl_table=11
/gene="esxO"
/gene_synonym="ES6_6"
/gene_synonym="Mtb9.9E"
/locus_tag="Rv2346c"
/product="Putative ESAT-6 like protein EsxO (ESAT-6 like
protein 6)"
/note="Rv2346c, (MT2411, MTCY98.15c), len: 94 aa.
EsxO,ESAT-6 like protein (see citation below), member of
Mycobacterium tuberculosis protein family with
O53942|Rv1793|MTV049.15,
O05300|Rv1198|MTCI364.10,MTCY15C10.33,
P96364|MTCY07H7B.03|Rv1037c|MTCY10G2.12,MTCI364.10, etc.
Belongs to the ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv2346c"
/db_xref="EnsemblGenomes-Tr:CCP45134"
/db_xref="GOA:P9WNI7"
/db_xref="InterPro:IPR009416"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:3OGI"
/db_xref="PDB:4GZR"
/db_xref="UniProtKB/Swiss-Prot:P9WNI7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45134.1"
/translation="MTINYQFGDVDAHGAMIRAQAGLLEAEHQAIVRDVLAAGDFWGG
AGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA"
gene complement(2626223..2626519)
/gene="esxP"
/gene_synonym="ES6_7"
/gene_synonym="QILSS"
/locus_tag="Rv2347c"
CDS complement(2626223..2626519)
/codon_start=1
/transl_table=11
/gene="esxP"
/gene_synonym="ES6_7"
/gene_synonym="QILSS"
/locus_tag="Rv2347c"
/product="Putative ESAT-6 like protein EsxP (ESAT-6 like
protein 7)"
/note="Rv2347c, (MT2412, MTCY98.16c), len: 98 aa.
EsxP,ESAT-6 like protein (see citation below). Member of
M. tuberculosis hypothetical QILSS protein family with
Rv1197,Rv1792, Rv1038c and Rv3620c. Belongs to the ESAT6
family. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2347c"
/db_xref="EnsemblGenomes-Tr:CCP45135"
/db_xref="GOA:P9WNI5"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:3OGI"
/db_xref="PDB:4GZR"
/db_xref="UniProtKB/Swiss-Prot:P9WNI5"
/protein_id="CCP45135.1"
/translation="MATRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAG
WSGMAEATSLDTMAQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS"
gene complement(2626654..2626980)
/locus_tag="Rv2348c"
CDS complement(2626654..2626980)
/codon_start=1
/transl_table=11
/locus_tag="Rv2348c"
/product="Hypothetical protein"
/note="Rv2348c, (MTCY98.17c), len: 108 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2348c"
/db_xref="EnsemblGenomes-Tr:CCP45136"
/db_xref="UniProtKB/TrEMBL:P95244"
/protein_id="CCP45136.1"
/translation="MLLPLGPPLPPDAVVAKRAESGMLGGLSVPLSWGVAVPPDDYDH
WAPAPEDGADVDVQAAEGADAEAAAMDEWDEWQAWNEWVAENAEPRFEVPRSSSSVIP
HSPAAG"
gene complement(2627172..2628698)
/gene="plcC"
/locus_tag="Rv2349c"
CDS complement(2627172..2628698)
/codon_start=1
/transl_table=11
/gene="plcC"
/locus_tag="Rv2349c"
/product="Probable phospholipase C 3 PlcC"
/note="Rv2349c, (MT2414, MTCY98.18c), len: 508 aa.
Probable plcC, phospolipase C 3 (see citations below),
similar to other precursors of several phospolipases C
e.g. P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase
C precursor from Pseudomonas aeruginosa (692 aa), FASTA
scores: opt: 1013, E(): 9.3e-54, (38.85% identity in 525
aa overlap); P06200|PHLC_PSEAE hemolytic phospholipase C
precursor from Pseudomonas aeruginosa (730 aa), FASTA
scores: opt: 630, E(): 1.5e-30, (35.15% identity in 535 aa
overlap); Q9S816|T12J13.18|T21P5.4 putative phospholipase
from Arabidopsis thaliana (Mouse-ear cress) (521 aa),
FASTA scores: opt: 218, E(): 1e-05, (27.05% identity in
451 aa overlap); etc. Also highly similar to others from
Mycobacterium tuberculosis e.g.
Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C phospholipase C 4
(514 aa), FASTA scores: opt: 2497, E(): 9e-144, (68.35%
identity in 509 aa overlap);
Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase
C 1 (520 aa), FASTA scores: opt: 2494, E(): 1.4e-143,
(68.1% identity in 514 aa overlap);
P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c phospholipase C
2 (512 aa), FASTA scores: opt: 2474, E(): 2.2e-142,
(67.65% identity in 513 aa overlap); etc. Belongs to the
bacterial phospholipase C family."
/db_xref="EnsemblGenomes-Gn:Rv2349c"
/db_xref="EnsemblGenomes-Tr:CCP45137"
/db_xref="GOA:P9WIB1"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR007312"
/db_xref="InterPro:IPR017850"
/db_xref="UniProtKB/Swiss-Prot:P9WIB1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45137.1"
/translation="MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIE
HIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKGWNPETQALDPTGITLPYRINTT
GGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIP
IHYLLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFT
WRIMPQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPA
YPWDFIRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKT
ALIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCF
VISPYSRGGLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAAPPD
PSPPNLDHPVRQLPKVAKCVPNVVLGFLNEGLPYRVPYPQTTPVQESGPARPIPSGIC
"
gene complement(2628781..2630319)
/gene="plcB"
/gene_synonym="mpcB"
/locus_tag="Rv2350c"
CDS complement(2628781..2630319)
/codon_start=1
/transl_table=11
/gene="plcB"
/gene_synonym="mpcB"
/locus_tag="Rv2350c"
/product="Membrane-associated phospholipase C 2 PlcB"
/note="Rv2350c, (MT2415, MTCY98.19c), len: 512 aa. plcB
(alternate gene name: mpcB), membrane-associated
phospolipase C 2 (see citations below), similar to other
precursors of several phospolipases C e.g.
P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C
precursor from Pseudomonas aeruginosa (692 aa), FASTA
scores: opt: 885, E(): 2.3e-44, (38.5% identity in 525 aa
overlap); P06200|PHLC_PSEAE hemolytic phospholipase C
precursor from Pseudomonas aeruginosa (730 aa), FASTA
scores: opt: 639, E(): 6.3e-30, (537 aa overlap); Q9RGS8
non-hemolytic phospholipase C from Pseudomonas aeruginosa
(700 aa), FASTA scores: opt: 864, E(): 3.9e-43, (39.2%
identity in 528 aa overlap); etc. Also highly similar to
others from Mycobacterium tuberculosis e.g.
Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase
C 1 (520 aa), FASTA scores: opt: 2788, E(): 4.5e-156,
(75.5% identity in 514 aa overlap);
Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C phospholipase C 4
(514 aa), FASTA scores: opt: 2623, E(): 2.1e-146, (71.5%
identity in 512 aa overlap);
P95245|PLCC|Rv2349c|MT2414|MTCY98.18c phospholipase C 3
(508 aa), FASTA scores: opt: 2474, E(): 1.1e-137, (67.65%
identity in 513 aa overlap); etc. Belongs to the bacterial
phospholipase C family. Supposed membrane-associated, at
the extracellular side. Substrate of Tat pathway (See
McDonough et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2350c"
/db_xref="EnsemblGenomes-Tr:CCP45138"
/db_xref="GOA:P9WIB3"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR007312"
/db_xref="InterPro:IPR017850"
/db_xref="UniProtKB/Swiss-Prot:P9WIB3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45138.1"
/translation="MTRRQFFAKAAAATTAGAFMSLAGPIIEKAYGAGPCPGHLTDIE
HIVLLMQENRSFDHYFGTLSDTRGFDDTTPPVVFAQSGWNPMTQAVDPAGVTLPYRFD
TTRGPLVAGECVNDPDHSWIGMHNSWNGGANDNWLPAQVPFSPLQGNVPVTMGFYTRR
DLPIHYLLADTFTVCDGYFCSLLGGTTPNRLYWMSAWIDPDGTDGGPVLIEPNIQPLQ
HYSWRIMPENLEDAGVSWKVYQNKLLGALNNTVVGYNGLVNDFKQAADPRSNLARFGI
SPTYPLDFAADVRNNRLPKVSWVLPGFLLSEHPAFPVNVGAVAIVDALRILLSNPAVW
EKTALIVNYDENGGFFDHVVPPTPPPGTPGEFVTVPDIDSVPGSGGIRGPIGLGFRVP
CLVISPYSRGPLMVHDTFDHTSTLKLIRARFGVPVPNLTAWRDATVGDMTSTFNFAAP
PNPSKPNLDHPRLNALPKLPQCVPNAVLGTVTKTAIPYRVPFPQSMPTQETAPTRGIP
SGLC"
gene complement(2630537..2632075)
/gene="plcA"
/gene_synonym="mpcA"
/locus_tag="Rv2351c"
CDS complement(2630537..2632075)
/codon_start=1
/transl_table=11
/gene="plcA"
/gene_synonym="mpcA"
/locus_tag="Rv2351c"
/product="Membrane-associated phospholipase C 1 PlcA
(MTP40 antigen)"
/note="Rv2351c, (MTP40, MT2416, MTCY98.20c), len: 512 aa.
plcA (alternate gene name: mpcA), membrane-associated
phospolipase C 1 (MTP40 antigen) (see citations
below),similar to other precursors of several
phospolipases C e.g. P15713|PHLN_PSEAE|PA3319
non-hemolytic phospholipase C precursor from Pseudomonas
aeruginosa (692 aa), FASTA scores: opt: 1064, E():
4.3e-55, (39.85% identity in 517 aa overlap);
P06200|PHLC_PSEAE hemolytic phospholipase C precursor from
Pseudomonas aeruginosa (730 aa), FASTA scores: opt: 562,
E(): 1.6e-25, (35.35% identity in 481 aa overlap);
Q9RGS8|PLCN|PHLN_BURPS non-hemolytic phospholipase C from
Burkholderia pseudomallei (Pseudomonas pseudomallei) (700
aa), FASTA scores: opt: 843, E(): 4.4e-42, (40.5% identity
in 531 aa overlap); etc. Also highly similar to others
from Mycobacterium tuberculosis e.g.
P95246|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c phospholipase C
2 (512 aa), FASTA scores: opt: 2788, E(): 1.2e-156, (75.5%
identity in 514 aa overlap) (alias
Q50561|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c phospholipase C
2 (521 aa), FASTA scores: opt: 2700, E(): 1.8e-151, (73.8%
identity in 515 aa overlap));
Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C phospholipase C 4
(514 aa), FASTA scores: opt: 2643, E(): 4.1e-148, (71.6%
identity in 511 aa overlap); etc. Belongs to the bacterial
phospholipase C family. Supposed membrane-associated, at
the extracellular side."
/db_xref="EnsemblGenomes-Gn:Rv2351c"
/db_xref="EnsemblGenomes-Tr:CCP45139"
/db_xref="GOA:P9WIB5"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR007312"
/db_xref="InterPro:IPR017850"
/db_xref="UniProtKB/Swiss-Prot:P9WIB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45139.1"
/translation="MSRREFLTKLTGAGAAAFLMDWAAPVIEKAYGAGPCPGHLTDIE
HIVLLMQENRSFDHYFGTLSSTNGFNAASPAFQQMGWNPMTQALDPAGVTIPFRLDTT
RGPFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQATTRAGPYVPLTMGYYTRQDIP
IHYLLADTFTICDGYHCSLLTGTLPNRLYWLSANIDPAGTDGGPQLVEPGFLPLQQFS
WRIMPENLEDAGVSWKVYQNKGLGRFINTPISNNGLVQAFRQAADPRSNLARYGIAPT
YPGDFAADVRANRLPKVSWLVPNILQSEHPALPVALGAVSMVTALRILLSNPAVWEKT
ALIVSYDENGGFFDHVTPPTAPPGTPGEFVTVPNIDAVPGSGGIRGPLGLGFRVPCIV
ISPYSRGPLMVSDTFDHTSQLKLIRARFGVPVPNMTAWRDGVVGDMTSAFNFATPPNS
TRPNLSHPLLGALPKLPQCIPNVVLGTTDGALPSIPYRVPYPQVMPTQETTPVRGTPS
GLCS"
gene complement(2632923..2634098)
/gene="PPE38"
/locus_tag="Rv2352c"
CDS complement(2632923..2634098)
/codon_start=1
/transl_table=11
/gene="PPE38"
/locus_tag="Rv2352c"
/product="PPE family protein PPE38"
/note="Rv2352c, (MTCY98.21c), len: 391 aa. PPE38, Member
of Mycobacterium tuberculosis PPE_family, highly similar
to many e.g. Q10778|MTCY48.17|Y04H_MYCTU (734 aa), FASTA
scores: opt: 713, E(): 2.8e-27, (37.7% identity in 430 aa
overlap); Q10540|MTCY31.06c,
Q11031|MTCY02B10.25c,Q10813|MTCY274.23c,
P42611|MTV037.06C, P71868|MTCY03C7.23,P95248|MTCY98.22c,
P71869|MTCY03C7.24c, etc."
/db_xref="EnsemblGenomes-Gn:Rv2352c"
/db_xref="EnsemblGenomes-Tr:CCP45140"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45140.1"
/translation="MILDFSWLPPEINSARIYAGAGSGPLFMAAAAWEGLAADLRASA
SSFDAVIAGLAAGPWSGPASVAMAGAAAPYVGWLSAAAGQAELSAGQATAAATAFEAA
LAATVHPAAVTANRVLLGALVATNILGQNTPAIAATEFDYVEMWAQDVGAMVGYHAGA
AAVAETLTPFSVPPLDLAGLASQAGAQLTGMATSVSAALSPIAEGAVEGVPAVVAAAQ
SVAAGLPVDAALQVGQAAAYPASMLIGPMMQLAQMGTTANTAGLAGAEAAGLAAADVP
TFAGDIASGTGLGGAGGLGAGMSAELGKARLVGAMSVPPTWEGSVPARMASSAMAGLG
AMPAEVPAAGGPMGMMPMPMGMGGAGAGMPAGMMGRGGANPHVVQARPSVVPRVGIG"
gene complement(2634528..2635592)
/gene="PPE39"
/locus_tag="Rv2353c"
CDS complement(2634528..2635592)
/codon_start=1
/transl_table=11
/gene="PPE39"
/locus_tag="Rv2353c"
/product="PPE family protein PPE39"
/note="Rv2353c, (MTCY98.22c), len: 354 aa. PPE39, Member
of Mycobacterium tuberculosis PPE family, highly similar
to many e.g. near ORF P95249|Rv2356c|MTCY98.25 from
Mycobacterium tuberculosis (615 aa), FASTA scores: opt:
1566, E(): 3.2e-69, (66.1% identity in 349 aa overlap);
Q10778|MTCY48.17, Q10540|MTCY31.06c,
E241779|MTCY98,Q10813|MTCY274.23c,
P71868|MTCY03C7.23,P71869|MTCY03C7.24c, P42611|MTV037.06C,
E64997|MTCY98,Q10707|MTCY49.38C, P71657|MTCY02B10.25c,
etc. Note that the ATG and RBS appear to be provided by
the IR of neighbouring IS6110. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2353c"
/db_xref="EnsemblGenomes-Tr:CCP45141"
/db_xref="InterPro:IPR002989"
/db_xref="UniProtKB/TrEMBL:Q79FF3"
/protein_id="CCP45141.1"
/translation="MPGRFRNFGSQNLGSGNIGSTNVGSGNIGSTNVGSGNIGDTNFG
NGNNGNFNFGSGNTGSNNIGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLNSGS
GNIGFGNSGTGNVGLFNSGTGNVGFGNSGTANTGFGNAGNVNTGFWNGGSTNTGLANA
GAGNTGFFDAGNYNFGSLNAGNINSSFGNSGDGNSGFLNAGDVNSGVGNAGDVNTGLG
NSGNINTGGFNPGTLNTGFFSAMTQAGPNSGFFNAGTGNSGFGHNDPAGSGNSGIQNS
GFGNSGYVNTSTTSMFGGNSGVLNTGYGNSGFYNAAVNNTGIFVTGVMSSGFFNFGTG
NSGLLVSGNGLSGFFKNLFG"
mobile_element 2635577..2636931
/mobile_element_type="insertion sequence:IS6110-8"
/note="IS6110-8, len: 1355 nt. Insertion sequence IS6110
element that appears to have inserted in 5'-end of
MTCY98.031c but is not flanked by expected 3 bp direct
repeats of target sequence."
repeat_region 2635577..2635604
/note="28 bp Inverted repeat,
TGAACCGCCCCGGCATGTCCGGAGACTC,at the left end of IS6110"
gene 2635628..2635954
/locus_tag="Rv2354"
CDS 2635628..2635954
/codon_start=1
/transl_table=11
/locus_tag="Rv2354"
/product="Probable transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv2354, (MTCY98.23), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv2354 and
Rv2355,the sequence UUUUAAAG (directly upstream of Rv2355)
maybe responsible for such a frameshifting event (see
McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv2354"
/db_xref="EnsemblGenomes-Tr:CCP45142"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP45142.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <2635903..2636889
/locus_tag="Rv2355"
CDS <2635903..2636889
/codon_start=1
/transl_table=11
/locus_tag="Rv2355"
/product="Probable transposase"
/note="Rv2355, (MTCY98.24), len: 328 aa. Probable IS6110
transposase. Identical to many other M. tuberculosis
IS6110 transposase subunits. The transposase described
here may be made by a frame shifting mechanism during
translation that fuses Rv2354 and Rv2355, the sequence
UUUUAAAG (directly upstream of Rv2355) maybe responsible
for such a frameshifting event (see McAdam et al., 1990).
Start changed since first submission (+ 16 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2355"
/db_xref="EnsemblGenomes-Tr:CCP45143"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP45143.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(2636904..2636931)
/note="28 bp Inverted repeat,
TGAACCGCCCCGGTGAGTCCGGAGACTC,at the right end of IS6110"
gene complement(2637688..2639535)
/gene="PPE40"
/locus_tag="Rv2356c"
CDS complement(2637688..2639535)
/codon_start=1
/transl_table=11
/gene="PPE40"
/locus_tag="Rv2356c"
/product="PPE family protein PPE40"
/note="Rv2356c, (MTCY98.25), len: 615 aa. PPE40, Member of
Mycobacterium tuberculosis PPE_family, highly similar to
others e.g. Q10778|MTCY48.17|YF48_MYCTU hypothetical
PPE-family protein (678 aa), FASTA scores: opt: 1888, E():
1.9e-78, (54.4% identity in 667 aa overlap);
Q10540|MTCY31.06c, E241779|MTCY98,
P42611|MTV037.06c,Q10813|MTCY274.23c,
P71657|MTCY02B10.25c, MTCY03C7.23,P71869|MTCY03C7.24c,
etc. Predicted to be an outer membrane protein (See Song
et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2356c"
/db_xref="EnsemblGenomes-Tr:CCP45144"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHZ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45144.1"
/translation="MVNFSVLPPEINSGRMFFGAGSGPMLAAAAAWDGLAAELGLAAE
SFGLVTSGLAGGSGQAWQGAAAAAMVVAAAPYAGWLAAAAARAGGAAVQAKAVAGAFE
AARAAMVDPVVVAANRSAFVQLVLSNVFGQNAPAIAAAEATYEQMWAADVAAMVGYHG
GASAAAAALAPWQQAVPGLSGLLGGAANAPAAAAQGAAQGLAELTLNLGVGNIGSLNL
GSGNIGGTNVGSGNVGGTNLGSGNYGSLNWGSGNTGTGNAGSGNTGDYNPGSGNFGSG
NFGSGNIGSLNVGSGNFGTLNLANGNNGDVNFGGGNTGDFNFGGGNNGTLNFGFGNTG
SGNFGFGNTGNNNIGIGLTGDGQIGIGGLNSGTGNIGFGNSGNNNIGFFNSGDGNIGF
FNSGDGNTGFGNAGNINTGFWNAGNLNTGFGSAGNGNVGIFDGGNSNSGSFNVGFQNT
GFGNSGAGNTGFFNAGDSNTGFANAGNVNTGFFNGGDINTGGFNGGNVNTGFGSALTQ
AGANSGFGNLGTGNSGWGNSDPSGTGNSGFFNTGNGNSGFSNAGPAMLPGFNSGFANI
GSFNAGIANSGNNLAGISNSGDDSSGAVNSGSQNSGAFNAGVGLSGFFR"
gene complement(2639673..2641064)
/gene="glyS"
/locus_tag="Rv2357c"
CDS complement(2639673..2641064)
/codon_start=1
/transl_table=11
/gene="glyS"
/locus_tag="Rv2357c"
/product="Probable glycyl-tRNA synthetase GlyS
(glycine--tRNA ligase) (GLYRS)"
/note="Rv2357c, (MTCY27.23, MTCY98.26), len: 463 aa.
Probable glyS, glycyl-tRNA synthetase, equivalent to
Q9CCG4|GLYS|ML0826 putative glycyl-tRNA synthase from
Mycobacterium leprae (463 aa), FASTA scores: opt:
2898,E(): 1e-179, (90.2% identity in 459 aa overlap). Also
highly similar to others e.g. Q9L2H9|SYG_STRCO|SCC121.07c
from Streptomyces coelicolor (460 aa), FASTA scores: opt:
2210, E(): 2.9e-135, (68.3% identity in 457 aa overlap);
Q9PPZ7|SYG_UREPA|GLYS|UU493 glycyl-tRNA synthetase from
Ureaplasma parvum (Ureaplasma urealyticum biotype 1) (473
aa), FASTA scores: opt: 1254, E(): 1.7e-73, (45.25%
identity in 462 aa overlap);
P75425|SYG_MYCPN|GLYS|MPN354|MP482 glycyl-tRNA synthetase
from Mycoplasma pneumoniae (449 aa), FASTA scores: opt:
1074, E(): 6.9e-62, (39.45% identity in 454 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop), and PS00179 Aminoacyl-transfer RNA synthetases
class-II signature 1. Belongs to class-II aminoacyl-tRNA
synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2357c"
/db_xref="EnsemblGenomes-Tr:CCP45145"
/db_xref="GOA:P9WFV7"
/db_xref="InterPro:IPR002314"
/db_xref="InterPro:IPR002315"
/db_xref="InterPro:IPR004154"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR022961"
/db_xref="InterPro:IPR027031"
/db_xref="InterPro:IPR033731"
/db_xref="InterPro:IPR036621"
/db_xref="UniProtKB/Swiss-Prot:P9WFV7"
/inference="protein motif:PROSITE:PS00179"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45145.1"
/translation="MHHPVAPVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVE
LKENIKRQWWRSVVTGRDDVVGIDSSIILPREVWVASGHVDVFHDPLVESLITHKRYR
ADHLIEAYEAKHGHPPPNGLADIRDPETGEPGQWTQPREFNMMLKTYLGPIETEEGLH
YLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEME
FFVEPATAKEWHQYWIDNRLQWYIDLGIRRENLRLWEHPKDKLSHYSDRTVDIEYKFG
FMGNPWGELEGVANRTDFDLSTHARHSGVDLSFYDQINDVRYTPYVIEPAAGLTRSFM
AFLIDAYTEDEAPNTKGGMDKRTVLRLDPRLAPVKAAVLPLSRHADLSPKARDLGAEL
RKCWNIDFDDAGAIGRRYRRQDEVGTPFCVTVDFDSLQDNAVTVRERDAMTQDRVAMS
SVADYLAVRLKGS"
gene 2641246..2641653
/gene="smtB"
/locus_tag="Rv2358"
CDS 2641246..2641653
/codon_start=1
/transl_table=11
/gene="smtB"
/locus_tag="Rv2358"
/product="Probable transcriptional regulatory protein SmtB
(probably ArsR-family)"
/note="Rv2358, (MTCY27.22c), len: 135 aa. Probable
smtB,transcriptional regulator, arsR family, equivalent to
Q9CCG5|ML0825 putative ArsR-family transcriptional
regulator from Mycobacterium leprae (140 aa), FASTA
scores: opt: 647, E(): 2e-34, (72.9% identity in 140 aa
overlap). Also similar to others e.g. BAB48273|MLR0745
Transcriptional regulator from Rhizobium loti
(Mesorhizobium loti) (104 aa), FASTA scores: opt: 185,
E(): 3.4e-05, (43.25% identity in 74 aa overlap) (has its
N-terminus shorter); P15905|ARR1_ECOLI arsenical
resistance operon repressor from Escherichia coli (117
aa), FASTA scores: opt: 164, E(): 8.1e-05, (39.1% identity
in 69 aa overlap); etc. Also similar to
O53838|Rv0827|MTV043.19c putative transcriptional
regulator from Mycobacterium tuberculosis (130 aa), FASTA
scores: opt: 201, E(): 4e-06,(35.7% identity in 98 aa
overlap); and O69711|Rv3744|MTV025.092 putative regulatory
protein from Mycobacterium tuberculosis (120 aa), FASTA
scores: opt: 209, E(): 1.2e-06, (35.5 % identity in 93 aa
overlap). Contains possible helix-turn-helix motif at aa
72-93 (Score 1103, +2.94 SD). Belongs to the ArsR family
of transciptional regulators. Shown to bind palindromic
DNA sequence upstream of Rv2358; inhibited by Zn2+ (See
Canneva et al., 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2358"
/db_xref="EnsemblGenomes-Tr:CCP45146"
/db_xref="GOA:P9WMI5"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45146.1"
/translation="MVTSPSTPTAAHEDVGADEVGGHQHPADRFAECPTFPAPPPREI
LDAAGELLRALAAPVRIAIVLQLRESQRCVHELVDALHVPQPLVSQHLKILKAAGVVT
GERSGREVLYRLADHHLAHIVLDAVAHAGEDAI"
gene 2641650..2642042
/gene="zur"
/gene_synonym="furB"
/locus_tag="Rv2359"
CDS 2641650..2642042
/codon_start=1
/transl_table=11
/gene="zur"
/gene_synonym="furB"
/locus_tag="Rv2359"
/product="Probable zinc uptake regulation protein Zur"
/note="Rv2359, (MTCY27.21c), len: 130 aa. Probable
zur,zinc uptake regulation protein, equivalent to
FURB|ML0824|Q9CCG6 putative ferric uptake regulatory
protein from Mycobacterium leprae (131 aa), FASTA scores:
opt: 765, E(): 1.7e-43, (86.9% identity in 130 aa
overlap). Also highly similar to ferric uptake regulation
proteins e.g. Q9L2H5|SCC121.11 putative metal uptake
regulation protein from Streptomyces coelicolor (139 aa),
FASTA scores: opt: 547, E(): 3.4e-29, (59.4% identity in
133 aa overlap); P06975|FUR_ECOLI from Escherichia coli
(148 aa),FASTA scores: opt: 322, E(): 1.9e-14, (37.9%
identity in 132 aa overlap); P45599|FUR_KLEPN ferric
uptake regulation protein from Klebsiella pneumoniae (155
aa), FASTA scores: opt: 314, E(): 6.7e-14, (36.35%
identity in 132 aa overlap); etc. Belongs to the fur/ZUR
family. Note that previously known as furB."
/db_xref="EnsemblGenomes-Gn:Rv2359"
/db_xref="EnsemblGenomes-Tr:CCP45147"
/db_xref="GOA:P9WN85"
/db_xref="InterPro:IPR002481"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:2O03"
/db_xref="UniProtKB/Swiss-Prot:P9WN85"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45147.1"
/translation="MSAAGVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGL
TTVYRTLQSMASSGLVDTLHTDTGESVYRRCSEHHHHHLVCRSCGSTIEVGDHEVEAW
AAEVATKHGFSDVSHTIEIFGTCSDCRS"
gene complement(2642150..2642578)
/locus_tag="Rv2360c"
CDS complement(2642150..2642578)
/codon_start=1
/transl_table=11
/locus_tag="Rv2360c"
/product="Unknown protein"
/note="Rv2360c, (MTCY27.20), len: 142 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv2360c"
/db_xref="EnsemblGenomes-Tr:CCP45148"
/db_xref="GOA:O05838"
/db_xref="UniProtKB/TrEMBL:O05838"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45148.1"
/translation="MPSLPDRLASILRDVLPAEEEPDGALTVRHDGTFASLRVVSIAE
DLELVSLTQILAWDLPLTKRLAEQVAKQARDINFGSVSLREKVSEKAARRSSGRPASN
TADVMLRYNFPGTGLTDDALRTLILLVLETGATIRSALVG"
gene complement(2642578..2643468)
/gene_synonym="uppS"
/locus_tag="Rv2361c"
CDS complement(2642578..2643468)
/codon_start=1
/transl_table=11
/gene_synonym="uppS"
/locus_tag="Rv2361c"
/product="Long (C50) chain Z-isoprenyl diphosphate
synthase (Z-decaprenyl diphosphate synthase)"
/note="Rv2361c, (MT2430, MTCY27.19), len: 296 aa. Long
(C50) chain Z-isoprenyl diphosphate synthase (see citation
below), equivalent to UPPS_MYCLE|ML0634|B1937_F2_65|P38119
undecaprenyl pyrophosphate synthetase from Mycobacterium
leprae (296 aa), FASTA scores: opt: 1789, E():
1.8e-97,(86.5% identity in 296 aa overlap). Also highly
similar to others e.g. UPPS|Q9L2H4 undecaprenyl
pyrophosphate synthetase from Streptomyces coelicolor (277
aa), FASTA scores: opt: 1098, E(): 8.2e-60, (63.5%
identity in 247 aa overlap); Q55482|UPPS_SYNY3|SLL0506
from Synechocystis sp. strain PCC 6803 (249 aa), FASTA
scores: opt: 686, E(): 4.2e-33, (46.4% identity in 235 aa
overlap); O67291|UPPS_AQUAE|AQ_1248 from Aquifex aeolicus
(231 aa),FASTA scores: opt: 684, E(): 5.2e-33, (46.3%
identity in 229 aa overlap); etc. Also similar to
Rv1086|MTV017.39 from Mycobacterium tuberculosis. Contains
PS01066 Hypothetical YBR002c family signature. Seems to
belong to the UPP synthetase family. Note that previously
known as uppS."
/db_xref="EnsemblGenomes-Gn:Rv2361c"
/db_xref="EnsemblGenomes-Tr:CCP45149"
/db_xref="GOA:P9WFF7"
/db_xref="InterPro:IPR001441"
/db_xref="InterPro:IPR018520"
/db_xref="InterPro:IPR036424"
/db_xref="PDB:2VG2"
/db_xref="PDB:2VG3"
/db_xref="PDB:2VG4"
/db_xref="PDB:4ONC"
/db_xref="UniProtKB/Swiss-Prot:P9WFF7"
/inference="protein motif:PROSITE:PS01066"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45149.1"
/translation="MARDARKRTSSNFPQLPPAPDDYPTFPDTSTWPVVFPELPAAPY
GGPCRPPQHTSKAAAPRIPADRLPNHVAIVMDGNGRWATQRGLARTEGHKMGEAVVID
IACGAIELGIKWLSLYAFSTENWKRSPEEVRFLMGFNRDVVRRRRDTLKKLGVRIRWV
GSRPRLWRSVINELAVAEEMTKSNDVITINYCVNYGGRTEITEATREIAREVAAGRLN
PERITESTIARHLQRPDIPDVDLFLRTSGEQRSSNFMLWQAAYAEYIFQDKLWPDYDR
RDLWAACEEYASRTRRFGSA"
gene complement(2643461..2644258)
/gene="recO"
/locus_tag="Rv2362c"
CDS complement(2643461..2644258)
/codon_start=1
/transl_table=11
/gene="recO"
/locus_tag="Rv2362c"
/product="Possible DNA repair protein RecO"
/note="Rv2362c, (MTCY27.18), len: 265 aa. RecO, DNA repair
protein, equivalent to Q9CCN0|ML0633 Mycobacterium leprae
Hypothetical protein (268 aa), FASTA scores: opt:
1560,E(): 8.5e-93, (86.6% identity in 268 aa overlap).
Also highly similar to others e.g. Q9L2H3|SCC121.13c DNA
repair protein recO from Streptomyces coelicolor (251 aa),
FASTA scores: opt: 843, E(): 6.9e-47, (52.2% identity in
249 aa overlap); and similar to other hypothetical
proteins. Weak similarity with P42095|RECO_BACSU DNA
repair protein recombinase from Bacillus subtilis (255
aa), FASTA scores: opt: 270, E(): 3.6e-10, (26.4% identity
in 182 aa overlap). Maybe involved in modulating assembly
and disassembly of RECA filaments (with RECF|Rv0003 and
RECR|Rv3715c) (see citation below). Contains match to Pfam
entry PF02565 Recombination protein O. Belongs to the RECO
family."
/db_xref="EnsemblGenomes-Gn:Rv2362c"
/db_xref="EnsemblGenomes-Tr:CCP45150"
/db_xref="GOA:P9WHI5"
/db_xref="InterPro:IPR003717"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR022572"
/db_xref="InterPro:IPR037278"
/db_xref="InterPro:IPR042242"
/db_xref="UniProtKB/Swiss-Prot:P9WHI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45150.1"
/translation="MRLYRDRAVVLRQHKLGEADRIVTLLTRDHGLVRAVAKGVRRTR
SKFGARLEPFAHIEVQLHPGRNLDIVTQVVSVDAFATDIVADYGRYTCGCAILETAER
LAGEERAPAPALHRLTVGALRAVADGQRPRDLLLDAYLLRAMGIAGWAPALTECARCA
TPGPHRAFHIATGGSVCAHCRPAGSTTPPLGVVDLMSALYDGDWEAAEAAPQSARSHV
SGLVAAHLQWHLERQLKTLPLVERFYQADRSVAERRAALIGQDIAGG"
gene 2644320..2645774
/gene="amiA2"
/locus_tag="Rv2363"
CDS 2644320..2645774
/codon_start=1
/transl_table=11
/gene="amiA2"
/locus_tag="Rv2363"
/product="Probable amidase AmiA2 (aminohydrolase)"
/note="Rv2363, (MTCY27.17c), len: 484 aa. Probable
amiA2,amidase, highly similar or similar to others e.g.
O28325|YJ54_ARCFU|AF1954 putative amidase from
Archaeoglobus fulgidus (453 aa), FASTA scores: opt:
777,E(): 1.1e-38, (35.0% identity in 474 aa overlap);
Q55424|AMID_SYNY3|SLL0828 putative amidase from
Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores:
opt: 770, E(): 3e-38, (36.4% identity in 456 aa overlap);
Q53116|AMDA enantiomerase-selective amidase from
Rhodococcus sp. (462 aa), FASTA scores: opt: 701, E():
3.5e-34, (32.7% identity in 468 aa overlap); etc. Also
highly similar to others from Mycobacterium tuberculosis
e.g. AMI2_MYCTU|AMIB2|Q11056|Rv1263|MT1301|MTCY50.19c|cy50
.19c amidase (462 aa), FASTA scores: opt: 1141, E():
2.9e-60,(45.4% identity in 454 aa overlap); etc. Contains
PS00571 Amidases signature, and PS00017 ATP/GTP-binding
site motif A (P-loop). Belongs to the amidase family."
/db_xref="EnsemblGenomes-Gn:Rv2363"
/db_xref="EnsemblGenomes-Tr:CCP45151"
/db_xref="GOA:P9WQ99"
/db_xref="InterPro:IPR000120"
/db_xref="InterPro:IPR020556"
/db_xref="InterPro:IPR023631"
/db_xref="InterPro:IPR036928"
/db_xref="UniProtKB/Swiss-Prot:P9WQ99"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00571"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45151.1"
/translation="MVGASGSDAGAISGSGNQRLPTLTDLLYQLATRAVTSEELVRRS
LRAIDVSQPTLNAFRVVLTESALADAAAADKRRAAGDTAPLLGIPIAVKDDVDVAGVP
TAFGTQGYVAPATDDCEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWSR
RHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAAWTHLVGIKPQRGRISTWPLPE
AFNGVTVNGVLARTVEDAALVLDAASGNVEGDRHQPPPVTVSDFVGIAPGPLKIALST
HFPYTGFRAKLHPEILAATQRVGDQLELLGHTVVKGNPDYGLRLSWNFLARSTAGLWE
WAERLGDEVTLDRRTVSNLRMGHVLSQAILRSARRHEAADQRRVGSIFDIVDVVLAPT
TAQPPPMARAFDRLGSFGTDRAIIAACPSTWPWNLLGWPSINVPAGFTSDGLPIGVQL
MGPANSEGMLISLAAELEAVSGWATKQPQVWWTS"
gene complement(2645771..2646673)
/gene="era"
/gene_synonym="bex"
/locus_tag="Rv2364c"
CDS complement(2645771..2646673)
/codon_start=1
/transl_table=11
/gene="era"
/gene_synonym="bex"
/locus_tag="Rv2364c"
/product="Probable GTP-binding protein Era"
/note="Rv2364c, (MT2433, MTCY27.16), len: 300 aa. Probable
era, GTP-binding protein, equivalent to
Q49768|ERA_MYCLE|ML0631|B1937_F3_102 GTP-binding protein
era homolog from Mycobacterium leprae (300 aa) FASTA
scores: opt: 1589, E(): 3.4e-88, (81.4% identity in 301 aa
overlap). Also highly similar to other GTP-binding
proteins e.g. Q9RDF2|ERA_STRCO|SCC77.06 from Streptomyces
coelicolor (317 aa), FASTA scores: opt: 1264, E():
1.1e-68, (64.0% identity in 306 aa overlap);
Q9KD52|ERA_BACHD|BH1367|BEX from Bacillus halodurans (304
aa), FASTA scores: opt: 869,(44.8% identity in 297 aa
overlap); Q9KIH7|ERA_LACLA|ERAL from Lactococcus lactis
(subsp. lactis) (Streptococcus lactis), and Lactococcus
lactis (subsp. cremoris) (Streptococcus cremoris) (303
aa), FASTA scores: opt: 781,E(): 9.4e-40, (40.25% identity
in 298 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop). Belongs to the era/TRME family of
GTP-binding proteins, era subfamily. Note that previously
known as bex."
/db_xref="EnsemblGenomes-Gn:Rv2364c"
/db_xref="EnsemblGenomes-Tr:CCP45152"
/db_xref="GOA:P9WNK9"
/db_xref="InterPro:IPR004044"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR005662"
/db_xref="InterPro:IPR006073"
/db_xref="InterPro:IPR009019"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR030388"
/db_xref="UniProtKB/Swiss-Prot:P9WNK9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45152.1"
/translation="MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHA
IRGIVHSDDFQIILVDTPGLHRPRTLLGKRLNDLVRETYAAVDVIGLCIPADEAIGPG
DRWIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTG
DRVDLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVV
IDEVSPREGRDDLIDVHAALYVERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKV
YLDLRVKVAKNWQRDPKQLGRLGF"
gene complement(2646747..2647088)
/locus_tag="Rv2365c"
CDS complement(2646747..2647088)
/codon_start=1
/transl_table=11
/locus_tag="Rv2365c"
/product="Conserved hypothetical protein"
/note="Rv2365c, (MTCY27.15), len: 113 aa. Conserved
hypothetical protein, highly similar to
Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein
from Mycobacterium leprae (108 aa), FASTA scores: opt:
426,E(): 1.4e-18, (67.9% identity in 106 aa overlap). Also
highly similar to Q9RDF3|SCC77.05 from Streptomyces
coelicolor (132 aa), FASTA scores: opt: 254, E():
1.9e-18,(53.1% identity in 96 aa overlap). Equivalent to
AAK46728 from Mycobacterium tuberculosis strain CDC1551
(93 aa) but longer 20 aa."
/db_xref="EnsemblGenomes-Gn:Rv2365c"
/db_xref="EnsemblGenomes-Tr:CCP45153"
/db_xref="GOA:O05833"
/db_xref="InterPro:IPR016193"
/db_xref="UniProtKB/TrEMBL:O05833"
/protein_id="CCP45153.1"
/translation="MMRRPITLAEQLDAEDAKLVVLARAAMARAEAGAGAAVRDVDGR
TYAAAPVALSALELTGLQAAVAAAVSSGATGLQAAVLVAGSVDDPGIAAVRELAPTAA
IIVTDRAGNPL"
gene complement(2647060..2648367)
/locus_tag="Rv2366c"
CDS complement(2647060..2648367)
/codon_start=1
/transl_table=11
/locus_tag="Rv2366c"
/product="Probable conserved transmembrane protein"
/note="Rv2366c, (MTCY27.14), len: 435 aa. Probable
conserved transmembrane protein, highly similar to
Q9L2L3|SCC117.07 putative membrane protein from
Streptomyces coelicolor (358 aa), FASTA scores: opt:
1159,E(): 5.5e-64, (53.0% identity in 353 aa overlap); ans
similar to hypothetical proteins and hemolysin-related
proteins e.g. Q9HN02|HLP|VNG2308G hemolysin protein from
Halobacterium sp. strain NRC-1 (457 aa), FASTA scores:
opt: 623, E(): 6.2e-31, (28.4% identity in 433 aa
overlap); etc. Potential transmembrane protein with 2 CBS
domains. Belongs to the UPF0053 family."
/db_xref="EnsemblGenomes-Gn:Rv2366c"
/db_xref="EnsemblGenomes-Tr:CCP45154"
/db_xref="GOA:P9WFP1"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR002550"
/db_xref="InterPro:IPR005170"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/Swiss-Prot:P9WFP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45154.1"
/translation="MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRP
GAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLA
SFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNG
PFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKT
AGQAMTLAVRSGHSRIPVIGENVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPA
VFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAE
TAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEV
ISHGLRLHAEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG"
gene complement(2648364..2648912)
/locus_tag="Rv2367c"
CDS complement(2648364..2648912)
/codon_start=1
/transl_table=11
/locus_tag="Rv2367c"
/product="Conserved hypothetical protein"
/note="Rv2367c, (MTCY27.13), len: 182 aa. Conserved
hypothetical protein, equivalent to
Q49752|YN67_MYCLE|ML0628|B1937_F1_21 hypothetical 19.8 KDA
protein from Mycobacterium leprae (178 aa), FASTA scores:
opt: 1051, E(): 2e-59, (89.1% identity in 175 aa overlap).
Also highly similar to others e.g. Q9L2L4|SCC117.06
conserved hypothetical protein from Streptomyces
coelicolor (165 aa), FASTA scores: opt: 599, E(): 6e-31,
(56.5% identity in 154 aa overlap); Q9KD56|BH1363
hypothetical protein from Bacillus halodurans (159 aa),
FASTA scores: opt: 311, E(): 8.3e-13, (45.05% identity in
111 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2367c"
/db_xref="EnsemblGenomes-Tr:CCP45155"
/db_xref="GOA:P9WGX9"
/db_xref="InterPro:IPR002036"
/db_xref="InterPro:IPR020549"
/db_xref="InterPro:IPR023091"
/db_xref="UniProtKB/Swiss-Prot:P9WGX9"
/protein_id="CCP45155.1"
/translation="MREHLMSIEVANESGIDVSEAELVSVARFVIAKMDVNPCAELSM
LLLDTAAMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPEFA
AEQAAAAGHSLGHELALLTIHGVLHLLGYDHAEPDEEKEMFALQDRLLEEWVADQVEA
YQHDRQDEKDRRLLDKSRYFDL"
gene complement(2648916..2649974)
/gene="phoH1"
/gene_synonym="phoH"
/locus_tag="Rv2368c"
CDS complement(2648916..2649974)
/codon_start=1
/transl_table=11
/gene="phoH1"
/gene_synonym="phoH"
/locus_tag="Rv2368c"
/product="Probable PHOH-like protein PhoH1 (phosphate
starvation-inducible protein PSIH)"
/note="Rv2368c, (MTCY27.12), len: 352 aa. Probable
phoH1,phoH-like protein (phosphate starvation-induced
protein),probably ATP-binding protein, equivalent to
Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-like protein
from Mycobacterium leprae (349 aa), FASTA scores: opt:
1952, E(): 4.7e-107, (88.9% identity in 352 aa overlap).
Also highly similar to Q9L2L5|SCC117.05 PHOH-like protein
from Streptomyces coelicolor (359 aa), FASTA scores: opt:
1407, E(): 3.6e-75, (63.6% identity in 349 aa overlap);
Q9RSY1|DR1988 PHOH-related protein from Deinococcus
radiodurans (380 aa), FASTA scores: opt: 1053, E():
1.9e-54, (53.3% identity in 349 aa overlap);
Q9KD58|PHOH|BH1361 phosphate starvation-induced protein
from Bacillus halodurans (320 aa), FASTA scores: opt:
1019,E(): 1.6e-52, (54.35% identity in 300 aa overlap);
P46343|PHOL_BACSU PHOH-like protein from Bacillus subtilis
(319 aa), FASTA scores: opt: 1014, E(): 3.2e-52, (50.8%
identity in 303 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the PHOH
family. Note that previously known as phoH."
/db_xref="EnsemblGenomes-Gn:Rv2368c"
/db_xref="EnsemblGenomes-Tr:CCP45156"
/db_xref="GOA:P9WIA3"
/db_xref="InterPro:IPR003714"
/db_xref="InterPro:IPR004087"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036612"
/db_xref="UniProtKB/Swiss-Prot:P9WIA3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45156.1"
/translation="MTSRETRAADAAGARQADAQVRSSIDVPPDLVVGLLGSADENLR
ALERTLSADLHVRGNAVTLCGEPADVALAERVISELIAIVASGQSLTPEVVRHSVAML
VGTGNESPAEVLTLDILSRRGKTIRPKTLNQKRYVDAIDANTIVFGIGPAGTGKTYLA
MAKAVHALQTKQVTRIILTRPAVEAGERLGFLPGTLSEKIDPYLRPLYDALYDMMDPE
LIPKLMSAGVIEVAPLAYMRGRTLNDAFIVLDEAQNTTAEQMKMFLTRLGFGSKVVVT
GDVTQIDLPGGARSGLRAAVDILEDIDDIHIAELTSVDVVRHRLVSEIVDAYARYEEP
GSGLNRAARRASGARGRR"
gene complement(2649946..2650248)
/locus_tag="Rv2369c"
CDS complement(2649946..2650248)
/codon_start=1
/transl_table=11
/locus_tag="Rv2369c"
/product="Hypothetical protein"
/note="Rv2369c, (MTCY27.11), len: 100 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2369c"
/db_xref="EnsemblGenomes-Tr:CCP45157"
/db_xref="UniProtKB/TrEMBL:L0TC46"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45157.1"
/translation="MIVGLADRHGHGRDVAAHRQAQLAGPRVAAVRRHRTGGHRQASS
RIKVSAHGLGVVRCAPTPSLTGVRMKLQHSSVRQVPVDRPESRHQKPGDVPRDPRC"
gene complement(2650245..2651558)
/locus_tag="Rv2370c"
CDS complement(2650245..2651558)
/codon_start=1
/transl_table=11
/locus_tag="Rv2370c"
/product="Conserved hypothetical protein"
/note="Rv2370c, (MTCY27.10), len: 437 aa. Conserved
hypothetical protein, member of family proteins from
Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807
conserved hypothetical protein from Mycobacterium
tuberculosis (432 aa), FASTA scores: opt: 1943, E():
9.4e-115, (69.9% identity in 409 aa overlap);
Rv1194c|MTCI364.06c; etc. Also similar to AAK45764|MT1500
conserved hypothetical protein from Mycobacterium
tuberculosis strain CDC1551 (432 aa), FASTA scores: opt:
1934, E(): 9.4e-115, (69.9% identity in 409 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2370c"
/db_xref="EnsemblGenomes-Tr:CCP45158"
/db_xref="InterPro:IPR025736"
/db_xref="InterPro:IPR041522"
/db_xref="InterPro:IPR042070"
/db_xref="UniProtKB/TrEMBL:O05828"
/protein_id="CCP45158.1"
/translation="MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIA
ADPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPDPLRMARDLVRRGLDASALD
VYRVGQNVAWQRWTEIAFGLTTDPQELHELLTLPFRSASEFIDATLAGLAAQMQLEYD
ELTRDVHAEHRRIVELILDGAPISRQSAEAKLGYPLDRSHTAAIIWYDDPDDNQNHLD
HTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTA
RGIDGFRRSHRDALATQRMLARLRSQQRLAFFADIHMIAVLTENPDSAADFITSTLGD
LESASPQLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQV
AVAISALQWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER"
gene 2651753..2651938
/gene="PE_PGRS40"
/locus_tag="Rv2371"
CDS 2651753..2651938
/codon_start=1
/transl_table=11
/gene="PE_PGRS40"
/locus_tag="Rv2371"
/product="PE-PGRS family protein PE_PGRS40"
/note="Rv2371, (MTCY27.09c), len: 61 aa. PE_PGRS40, Short
protein, member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to N-terminal part of others e.g.
AAK44356|MT0132 PE_PGRS family protein from Mycobacterium
tuberculosis strain CDC1551 (561 aa), FASTA scores: opt:
217, E(): 4.9e-08, (69.65% identity in 56 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2371"
/db_xref="EnsemblGenomes-Tr:CCP45159"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FE9"
/protein_id="CCP45159.1"
/translation="MSLVSVAPELVVTAVPDVARIGSSIGAPDTAAAARPTTSVLAAG
ADEVSADVVALFGWVAR"
gene complement(2652037..2652825)
/locus_tag="Rv2372c"
CDS complement(2652037..2652825)
/codon_start=1
/transl_table=11
/locus_tag="Rv2372c"
/product="Conserved hypothetical protein"
/note="Rv2372c, (MTCY27.08), len: 262 aa. Conserved
hypothetical protein, equivalent to Q9CCN1|ML0626
hypothetical protein from Mycobacterium leprae (257
aa),FASTA scores: opt: 1277, E(): 3e-71, (77.25% identity
in 255 aa overlap). Also highly similar to others e.g.
Q9RDD9|SDRD hypothetical 26.1 KDA protein from
Streptomyces coelicolor (249 aa), FASTA scores: opt: 624,
E(): 3.2e-31,(45.05% identity in 253 aa overlap);
P54461|YQEU_BACSU hypothetical 28.8 kDa protein from
Bacillus subtilis (256 aa), FASTA scores: opt: 375, E():
6e-16, (32.5% identity in 234 aa overlap); etc. C-terminal
half highly similar to Q49763|B1937_F2_57 from
Mycobacterium leprae (128 aa),FASTA scores: opt: 577, E():
1.4e-28, (75.8% identity in 124 aa overlap). Belongs to
the UPF0088 family."
/db_xref="EnsemblGenomes-Gn:Rv2372c"
/db_xref="EnsemblGenomes-Tr:CCP45160"
/db_xref="GOA:P9WGX1"
/db_xref="InterPro:IPR006700"
/db_xref="InterPro:IPR015947"
/db_xref="InterPro:IPR029026"
/db_xref="InterPro:IPR029028"
/db_xref="PDB:4L69"
/db_xref="UniProtKB/Swiss-Prot:P9WGX1"
/protein_id="CCP45160.1"
/translation="MVAMLFYVDTLPDTGAVAVVDGDEGFHAATVRRIRPGEQLVLGD
GVGRLARCVVEQAGRGGLRARVLRRWSVPPVRPPVTVVQALPKSERSELAIELATEAG
ADAFLAWQAARCVANWDGARVDKGLRRWRAVVRSAARQSRRARIPPVDGVLSTPMLVQ
RVREEVAAGAAVLVLHEEATERIVDIAAAQAGSLMLVVGPEGGIAPDELAALTDAGAV
AVRLGPTVLRTSTAAAVALGAVGVLTSRWDASASDCEYCDVTRR"
gene complement(2652839..2653987)
/gene="dnaJ2"
/locus_tag="Rv2373c"
CDS complement(2652839..2653987)
/codon_start=1
/transl_table=11
/gene="dnaJ2"
/locus_tag="Rv2373c"
/product="Probable chaperone protein DnaJ2"
/note="Rv2373c, (MTCY27.07), len: 382 aa. Probable
dnaJ2,chaperone protein, equivalent to
Q49762|DNJ2_MYCLE|ML0625|B1937_F2_56 chaperone protein
from Mycobacterium leprae (378 aa), FASTA scores: opt:
2301,E(): 1.7e-120, (87.5% identity in 382 aa overlap).
Also highly similar to other chaperone proteins DNAJ/DNAJ2
e.g. Q9RDD7|DNJ2_STRCO|SCC77.21c from Streptomyces
coelicolor (378 aa), FASTA scores: opt: 1456, E():
1.2e-73, (54.8% identity in 385 aa overlap);
O52164|DNJ2_STRAL from Streptomyces albus (379 aa) FASTA
scores: opt: 1378, E(): 2.6e-69, (52.2% identity in 385 aa
overlap); Q9S5A3|DNAJ_LISMO from Listeria monocytogenes
(377 aa),FASTA scores: opt: 1013, E(): 4.6e-49, (41.3%
identity in 385 aa overlap); etc. Also similar to
Rv0352|MTCY13E10.12 from Mycobacterium tuberculosis.
Contains 1 J domain and 1 cr domain. Belongs to the DNAJ
family."
/db_xref="EnsemblGenomes-Gn:Rv2373c"
/db_xref="EnsemblGenomes-Tr:CCP45161"
/db_xref="GOA:P9WNV7"
/db_xref="InterPro:IPR001305"
/db_xref="InterPro:IPR001623"
/db_xref="InterPro:IPR002939"
/db_xref="InterPro:IPR008971"
/db_xref="InterPro:IPR012724"
/db_xref="InterPro:IPR036410"
/db_xref="InterPro:IPR036869"
/db_xref="UniProtKB/Swiss-Prot:P9WNV7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45161.1"
/translation="MARDYYGLLGVSKNASDADIKRAYRKLARELHPDVNPDEAAQAK
FKEISVAYEVLSDPDKRRIVDLGGDPLESAAAGGNGFGGFGGLGDVFEAFFGGGFGGG
AASRGPIGRVRPGSDSLLRMRLDLEECATGVTKQVTVDTAVLCDRCQGKGTNGDSVPI
PCDTCGGRGEVQTVQRSLLGQMLTSRPCPTCRGVGVVIPDPCQQCMGDGRIRARREIS
VKIPAGVGDGMRVRLAAQGEVGPGGGPAGDLYVEVHEQAHDVFVREGDHLHCTVSVPM
VDAALGVTVTVDAILDGLSEITIPPGTQPGSVITLRGRGMPHLRSNTRGDLHVHVEVV
VPTRLDHQDIELLRELKGRRDREVAEVRSTHAAAGGLFSRLRETFTGR"
gene complement(2654062..2655093)
/gene="hrcA"
/locus_tag="Rv2374c"
CDS complement(2654062..2655093)
/codon_start=1
/transl_table=11
/gene="hrcA"
/locus_tag="Rv2374c"
/product="Probable heat shock protein transcriptional
repressor HrcA"
/note="Rv2374c, (MTCY27.06), len: 343 aa. Probable
hrcA,heat-inducible transcriptional repressor (see
citation below), equivalent to Q9CCN2|HRCA|ML0624 putative
heat-inducible transcriptional regulator from
Mycobacterium leprae (343 aa), FASTA scores: opt: 1926,
E(): 3.9e-107,(89.8% identity in 343 aa overlap). Also
highly similar to other heat-inducible transcription
repressor proteins e.g. Q9RDD6|HRCA|SCC77.22c from
Streptomyces coelicolor (338 aa), FASTA scores: opt: 1227,
E(): 1.1e-65, (58.8% identity in 335 aa overlap);
O52163|HRCA_STRAL from Streptomyces albus (338 aa), FASTA
scores: opt: 1196, E(): 7.7e-64,(56.1% identity in 335 aa
overlap); P25499|HRCA_BACSU heat-inducible transcription
repressor from Bacillus subtilis (343 aa), FASTA scores:
opt: 538, E(): 8.4e-25,(28.9% identity in 325 aa overlap);
etc. Almost identical,but conflict at C-terminus, to
Q49749|YGRP|B1937_F1_18 putative heat-inducible
transcription repressor from Mycobacterium leprae (197 aa)
FASTA scores: opt: 1126, E(): 6.9e-60, (91.8% identity in
195 aa overlap). Belongs to the HRCA family."
/db_xref="EnsemblGenomes-Gn:Rv2374c"
/db_xref="EnsemblGenomes-Tr:CCP45162"
/db_xref="GOA:P9WMK3"
/db_xref="InterPro:IPR002571"
/db_xref="InterPro:IPR021153"
/db_xref="InterPro:IPR023120"
/db_xref="InterPro:IPR029016"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45162.1"
/translation="MGSADERRFEVLRAIVADFVATQEPIGSKSLVERHNLGVSSATV
RNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSSAERRAIQSFLESGV
DLDDVLRRAVRLLAQLTRQVAVVQYPTLSTSTVRHLEVIALTPARLLMVVITDSGRVD
QRIVELGDVIDDHQLAQLREILGQALEGKKLSAASVAVADLASQLGGAGGLGDAVGRA
ATVLLESLVEHTEERLLLGGTANLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEA
GKVTVRIGHETASEQMVGTSMVSTAYGTAHTVYGGMGVVGPTRMDYPGTIASVAAVAL
YIGDVLGAR"
gene 2655265..2655582
/locus_tag="Rv2375"
CDS 2655265..2655582
/codon_start=1
/transl_table=11
/locus_tag="Rv2375"
/product="Conserved hypothetical protein"
/note="Rv2375, (MTCY27.05c), len: 105 aa. Conserved
hypothetical protein, highly similar to only
CAC32314|2SCD60.09c conserved hypothetical protein from
Streptomyces coelicolor (98 aa), FASTA scores: opt:
425,E(): 5.7e-24, (63.25% identity in 98 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2375"
/db_xref="EnsemblGenomes-Tr:CCP45163"
/db_xref="InterPro:IPR014447"
/db_xref="UniProtKB/TrEMBL:O05823"
/protein_id="CCP45163.1"
/translation="MIFKGVREGKPYPEHGLSYRDWSQIPPQQIRLDELVTTTTVLAL
DRLLSEDSTFYGDLFPHAVKWRGTTYLEDGLHRAVRAALRNRTVLHARVFDMDASPGG
RRS"
gene complement(2655609..2656115)
/gene="cfp2"
/gene_synonym="mtb12"
/locus_tag="Rv2376c"
CDS complement(2655609..2656115)
/codon_start=1
/transl_table=11
/gene="cfp2"
/gene_synonym="mtb12"
/locus_tag="Rv2376c"
/product="Low molecular weight antigen CFP2 (low molecular
weight protein antigen 2) (CFP-2)"
/note="Rv2376c, (MT2445, MTCY27.04), len: 168 aa. Cfp2
(alternate gene name: mtb12), low molecular weight
antigen,secreted protein similar to
Q49771|MB12_MYCLE|ML0620|B1937_F3_91 low molecular weight
antigen MTB12 homolog precursor from Mycobacterium leprae
(167 aa), FASTA scores: opt: 682, E(): 1.7e-32, (65.5%
identity in 165 aa overlap). Belongs to the MTB12 family.
A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004). Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2376c"
/db_xref="EnsemblGenomes-Tr:CCP45164"
/db_xref="GOA:P9WIN7"
/db_xref="UniProtKB/Swiss-Prot:P9WIN7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45164.1"
/translation="MKMVKSIAAGLTAAAAIGAAAAGVTSIMAGGPVVYQMQPVVFGA
PLPLDPASAPDVPTAAQLTSLLNSLADPNVSFANKGSLVEGGIGGTEARIADHKLKKA
AEHGDLPLSFSVTNIQPAAAGSATADVSVSGPKLSSPVTQNVTFVNQGGWMLSRASAM
ELLQAAGN"
gene complement(2656215..2656430)
/gene="mbtH"
/locus_tag="Rv2377c"
CDS complement(2656215..2656430)
/codon_start=1
/transl_table=11
/gene="mbtH"
/locus_tag="Rv2377c"
/product="Putative conserved protein MbtH"
/note="Rv2377c, (MT2445.1, MTCY27.03), len: 71 aa.
Putative mbtH, conserved protein with no function assigned
(see Quadri et al., 1998; De Voss et al., 1999), similar
to hypothetical proteins or proteins found in several gene
clusters for biosynthesis or transport of siderophores and
other nonribosomally synthesized peptides e.g.
Q9Z388|SCE8.11c putative small conserved hypothetical
protein from Streptomyces coelicolor (71 aa), FASTA
scores: opt: 345, E(): 1.4e-19, (68.2% identity in 66 aa
overlap); Q9F8V3|CUMB COUY protein (probably involved in
the biosynthesis of aminocoumarin antibiotic coumermycin
a(1)) (see Wang et al., 2000) from Streptomyces
rishiriensis (71 aa), FASTA scores: opt: 329, E():
2.2e-18, (63.2% identity in 68 aa overlap); Q9F5J2|SIM-CB
MBTH-like protein (probably protein involved in the
biosynthesis of aminocoumarin antibiotic coumermycin a(1))
from Streptomyces antibioticus (70 aa), FASTA scores: opt:
308,E(): 8.4e-17, (65.6% identity in 64 aa overlap);
Q9FB14 MBTH-like protein (involved in the biosynthesis of
the antitumor drug bleomycin) (see Du et al., 2000) from
Streptomyces verticillus FASTA scores: opt: 220, E():
8.8e-10, (41.2% identity in 68 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2377c"
/db_xref="EnsemblGenomes-Tr:CCP45165"
/db_xref="GOA:P9WIP5"
/db_xref="InterPro:IPR005153"
/db_xref="InterPro:IPR037407"
/db_xref="InterPro:IPR038020"
/db_xref="PDB:2KHR"
/db_xref="UniProtKB/Swiss-Prot:P9WIP5"
/protein_id="CCP45165.1"
/translation="MSTNPFDDDNGAFFVLVNDEDQHSLWPVFADIPAGWRVVHGEAS
RAACLDYVEKNWTDLRPKSLRDAMVED"
gene complement(2656408..2657703)
/gene="mbtG"
/locus_tag="Rv2378c"
CDS complement(2656408..2657703)
/codon_start=1
/transl_table=11
/gene="mbtG"
/locus_tag="Rv2378c"
/product="Lysine-N-oxygenase MbtG (L-lysine
6-monooxygenase) (lysine N6-hydroxylase)"
/note="Rv2378c, (MTCY27.02), len: 431 aa.
MbtG,lysine-N-oxygenase (hydroxylase) (EC 1.13.12.10 or
1.14.13.59; depending if enzyme is NADPH dependent or
independent) (see citations below), showing some
similarity with various proteins including ornithine and
lysine-N-oxygenases, e.g. Q9K6Q1|TRKA|BH3677 potassium
uptake protein from Bacillus halodurans (350 aa), FASTA
scores: opt: 153, E(): 0.016, (25.2% identity in 246 aa
overlap); P56584|SID1_USTMA L-ornithine 5-monooxygenase
from Ustilago maydis (Smut fungus) (570 aa), FASTA scores:
opt: 136, E(): 0.31, (22.85% identity in 127 aa overlap);
Q9HHV0|HXYA|VNG6214G monooxygenase from Halobacterium sp.
strain NRC-1 (477 aa), FASTA scores: opt: 119, E():
3.4,(40.0% identity in 70 aa overlap); O69828|SC1A6.23
putative lysine N-hydroxlase (fragment) from Streptomyces
coelicolor (134 aa), blast score: 76 (similarity in part
for this one); etc. Cofactors: FAD (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv2378c"
/db_xref="EnsemblGenomes-Tr:CCP45166"
/db_xref="GOA:P9WKF7"
/db_xref="InterPro:IPR025700"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WKF7"
/protein_id="CCP45166.1"
/translation="MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGA
NWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASF
AEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQAD
ALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNEL
FRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSA
TVQEALLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGAD
PLWFTSLFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGP
GFPNLSCLGLLSDRVLGAGIFTPTKHNDTRRSGEHQSFR"
gene complement(2657700..2662085)
/gene="mbtF"
/locus_tag="Rv2379c"
CDS complement(2657700..2662085)
/codon_start=1
/transl_table=11
/gene="mbtF"
/locus_tag="Rv2379c"
/product="Peptide synthetase MbtF (peptide synthase)"
/note="Rv2379c, (MTCY27.01), len: 1461 aa. MbtF, peptide
synthetase (see citations below), similar in part to
several synthases e.g. O52820|PCZA363.4 protein from
Amycolatopsis orientalis (4077 aa), FASTA scores: opt:
1873, E(): 1.1e-99, (35.55% identity in 1522 aa overlap);
O07944|SNBDE pristinamycin I synthase 3 and 4 from
Streptomyces pristinaespiralis (4848 aa), FASTA scores:
opt: 1817, E(): 2.1e-96, (33.65% identity in 1463 aa
overlap); O52821 protein similar to peptide synthetase
from Amycolatopsis orientalis (1860 aa) FASTA scores: opt:
1705,E(): 2.9e-90, (34.75% identity in 1344 aa overlap);
Q9XCF2|PSTB putative peptide synthetase (similar to
Mycobacterium tuberculosis nrp protein) from Mycobacterium
avium (2552 aa), FASTA scores: opt: 1687, E():
4e-89,(35.45% identity in 1058 aa overlap); Q9ZET7 peptide
synthetase (fragment) from Mycobacterium smegmatis (1438
aa), FASTA scores: opt: 1479, E(): 2.5e-77, (30.45%
identity in 1507 aa overlap); etc. Contains PS00455
putative AMP-binding domain signature. Belongs to the
ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv2379c"
/db_xref="EnsemblGenomes-Tr:CCP45167"
/db_xref="GOA:O05819"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR010071"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:O05819"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45167.1"
/translation="MGPVAVTRADARGAIDDVMALSPLQQGLFSRATLVAAESGSEAA
EADPYVIAMAADAAGPLDIALLRDCAAAMLTRHPNLRASFLHGNLSRPVQVIPSSAEV
LWRHVRAHPSEVGALAAEERRRRFDVGRGPLIRFLLIELPDECWHLVIVAHHIVIDGW
SLPLFVSELLALYRAGGHVAALPAAPRPYRDYIGWLAGRDQTASRAMWADHLNGLDGP
TLLSPALADTPVQPGIPGRTEVRLDREATAELADAARTRGVTISTLVQMAWATTLSAF
TGRGDVTFGVTVSGRPSELSGVETMIGLFINTVPLRVRLDARATVGGQCAVLQRQFAM
LRDHSYLGFNEFRAIAGIGEMFDTLLVYENFPPGEVVGTAEFVANGVTFRPVALESLS
HFPVTVAAHRSTGELTLLVEVLDGALGTMAPESLGRRVLAVLQRLVSRWDRPLRDVDI
LLDGEHDPTAPGLPDVTTSAPAVHTRFAEIAAAQPDSVAVSWADGQLTYRELDALADR
LATGLRRADVSRETPVAVALSRGPRYVAAMLAVLKAGGMIVPLDPAMPGERVAEILRQ
TSAPVVIDEGVFAASVGADILEEDRAITVPVDQAAYVIFTSGTTGTPKGVIGTHRALS
AYADDHIERVLRPAAQRLGRPLRIAHAWSFTFDAAWQPLVALLDGHAVHIVDDHRQRD
AGALVEAIDRFGLDMIDTTPSMFAQLHNAGLLDRAPLAVLALGGEALGAATWRMIQQN
CARTAMTAFNCYGPTETTVEAVVAAVAEHARPVIGRPTCTTRAYVMDSWLRPVPDGVA
GELYLAGAQLTRGYLGRPAETAARFVAEPNGRGSRMYRTGDVVRRLPDGGLEFLGRSD
DQVKIRGFRVEPGEIAAVLNGHHAVHGCHVTARGHASGPRLTAYVAGGPQPPPVAELR
AMLLERLPRYLVPHHIVVLDELPLTPHGKIDENALAAINVTEGPATPPQTPTELVLAE
AFADVMETSNVDVTAGFLQMGLDSIVALSVVQAARRRGIALRARLMVECDTIRELAAA
IDSDAAWQAPANDAGEPIPVLPNTHWLYEYGDPRRLAQTEVIRLPDRITRERLDAVLA
AVVDGHEVLRCRFDRDAMALVAQPKTDILSEVWVSGELVTAVAEQTLGALASLDPQAG
RLLSAVWLREPDGPGVLVLTAHVLAMDPASWRIVLGELDAGLHALAAGRAPSPARENT
SYRQWSRLLAQRAKALDSVDFWVAELEGADPPLGARRVAPQTDRVGELAITMSISDAD
LTARLLSTGRSMTDLLATAAARMVTAWRRQRGQQTPAPLLALETHGRADVHVDKTADT
SDTVGLLSAIYPLRIHCDGATDFARIPGSGIDYGLLRYLRADTAERLRAHREPQLLLN
YLGSLHVGVGDLAVDRALLADVGQLPEPEQPVRHELTVLAALLGPADAPVLATRWRTL
PDILSADDVATLQSLWQGALAEITA"
gene complement(2662067..2667115)
/gene="mbtE"
/locus_tag="Rv2380c"
CDS complement(2662067..2667115)
/codon_start=1
/transl_table=11
/gene="mbtE"
/locus_tag="Rv2380c"
/product="Peptide synthetase MbtE (peptide synthase)"
/note="Rv2380c, (MTCY22H8.05), len: 1682 aa. MbtE, peptide
synthetase (see citations below), similar in part to
several synthases e.g. O07944|SNBDE pristinamycin I
synthase 3 and 4 from Streptomyces pristinaespiralis (4848
aa), FASTA scores: opt: 2635, E(): 1.9e-146, (36.8%
identity in 1657 aa overlap); O05647|SNBDE virginiamycin S
synthetase (fragment) from Streptomyces virginiae (1997
aa) FASTA scores: opt: 2580, E(): 1.6e-143, (40.65%
identity in 1163 aa overlap); Q9R9I2|DHBF protein involved
in siderophore production from Bacillus subtilis (2378
aa),FASTA scores: opt: 2388, E(): 3.6e-132, (33.9%
identity in 1579 aa overlap); O68487|ACMB actinomycin
synthetase II from Streptomyces chrysomallus (2611 aa),
FASTA scores: opt: 2165, E(): 4.9e-119, (35.0% identity in
1634 aa overlap); etc. Equivalent to AAK46743 from
Mycobacterium tuberculosis strain CDC1551 (1787 aa) but
shorter 105 aa. Contains PS00455 putative AMP-binding
domain signature, and PS00012 Phosphopantetheine
attachment site. Belongs to the ATP-dependent AMP-binding
enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv2380c"
/db_xref="EnsemblGenomes-Tr:CCP45168"
/db_xref="GOA:I6Y0L1"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR010071"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:I6Y0L1"
/inference="protein motif:PROSITE:PS00012"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45168.1"
/translation="MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRI
LRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSR
DAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP
SAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARV
ATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAM
RLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFR
EPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQM
LRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTT
RTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALG
VVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTDADRIRPLR
PDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSI
AEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQW
RTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPI
GRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGS
RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD
LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITA
HGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSL
LATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRL
SSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI
GGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQT
VLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDD
GAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVS
RDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND
LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQM
PQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQ
RFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPV
PVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQL
ELLAEIERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSIL
ATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSP
DELSALTASWDQWP"
gene complement(2667255..2670269)
/gene="mbtD"
/locus_tag="Rv2381c"
CDS complement(2667255..2670269)
/codon_start=1
/transl_table=11
/gene="mbtD"
/locus_tag="Rv2381c"
/product="Polyketide synthetase MbtD (polyketide
synthase)"
/note="Rv2381c, (MTCY22H8.04), len: 1004 aa.
MbtD,polyketide synthase (see citations below), similar in
part to several synthases e.g. Q03132|ERY2_SACER|ERYA
erythronolide synthase, modules 3 and 4 from
Saccharopolyspora erythraea (Streptomyces erythraeus)
(3567 aa), FASTA scores: opt: 971, E(): 1e-46, (29.35%
identity in 1043 aa overlap); Q9F829|megaii megalomicin
6-deoxyerythronolide B synthase 2 from Micromonospora
megalomicea subsp. nigra (3562 aa), FASTA scores: opt:
787,E(): 2.4e-36, (29.35% identity in 1032 aa overlap);
Q9L4W4|NYSB polyketide synthase from Streptomyces noursei
(3192 aa), FASTA scores: opt: 761, E(): 6.6e-35, (29.55%
identity in 1086 aa overlap); O30764|NIDA1 polyketide
synthase modules 1 and 2 from Streptomyces caelestis (4340
aa), FASTA scores: opt: 726, E(): 7.8e-33, (27.3% identity
in 1052 aa overlap); etc. Contains PS00012
Phosphopantetheine attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2381c"
/db_xref="EnsemblGenomes-Tr:CCP45169"
/db_xref="GOA:P71719"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/TrEMBL:P71719"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45169.1"
/translation="MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTE
VARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFP
GQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEI
EIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARAN
VVGRLPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDT
VRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGT
TFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGP
AVLVGSARRGERFVDALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAV
PMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAID
SHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVC
LVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVI
TAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHY
ARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGG
VGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSV
MGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVT
IARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLDSRQFERYEGPTDPN
LTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLAT
LMGDITGDGLVAKLEDADERSHTAQKVDISRD"
gene complement(2670269..2671603)
/gene="mbtC"
/locus_tag="Rv2382c"
CDS complement(2670269..2671603)
/codon_start=1
/transl_table=11
/gene="mbtC"
/locus_tag="Rv2382c"
/product="Polyketide synthetase MbtC (polyketide
synthase)"
/note="Rv2382c, (MTCY22H8.03), len: 444 aa.
MbtC,polyketide synthase (see citations below), similar in
part to several synthases e.g. Q9F7T9 avermectin
polyketide synthase (fragment) from Streptomyces
avermitilis (3626 aa), FASTA scores: opt: 1458, E():
7e-82, (50.65% identity in 446 aa overlap); AAG23264|SPNA
polyketide synthase loading and extender module 1 from
Saccharopolyspora spinosa (2595 aa) FASTA scores: opt:
1441, E(): 6e-81,(49.1% identity in 446 aa overlap);
O33954|TYLG tylactone synthase starter module and modules
1 & 2 from Streptomyces fradiae (4472 aa) FASTA scores:
opt: 1439, E(): 1.2e-80,(51.0% identity in 447 aa
overlap); O30764|NIDA1 polyketide synthase modules 1 and 2
from Streptomyces caelestis (4340 aa) FASTA scores: opt:
1432, E(): 3.3e-80, (50.9% identity in 442 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2382c"
/db_xref="EnsemblGenomes-Tr:CCP45170"
/db_xref="GOA:P71718"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020841"
/db_xref="UniProtKB/TrEMBL:P71718"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45170.1"
/translation="MSDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDR
GWALRELFDGSRRNGFKPIHNLGGFLSSATTFDPEFFRISPREATAMDPQQRVGLRVA
WRTLENSGINPDDLAGHDVGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIA
YTLDLAGPALTVDTSCSSALAAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQ
HALSDDGHCRPYSAHASGTAWAEGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLS
DGLTAPSGDAQTRLLRRAIAQAAVVPADVGMVEGHGTATRLGDRTELRSLAASYGTAP
AGRGPLLGSVKSNIGHAQAAAGGLGLVKVILAAQHAAIPPTLHVDEPSREIDWEKQGL
RLADKLTPWRAVDGWRTAAVSAFGMSGTNSHVIVSMPDTVSAPERGPECGEV"
gene complement(2671593..2675837)
/gene="mbtB"
/locus_tag="Rv2383c"
CDS complement(2671593..2675837)
/codon_start=1
/transl_table=11
/gene="mbtB"
/locus_tag="Rv2383c"
/product="Phenyloxazoline synthase MbtB (phenyloxazoline
synthetase)"
/note="Rv2383c, (MTCY22H8.02), len: 1414 aa.
MbtB,phenyloxazoline synthase (see citations below),
similar to the N-terminal region of several synthetases
e.g. Q9EWP5|SC4C2.17 putative non-ribosomal peptide
synthase from Streptomyces coelicolor (2229 aa), FASTA
scores: opt: 2878, E(): 4.1e-156, (46.85% identity in 1138
aa overlap); Q9Z399|IRP2 yersiniabactin biosynthetic from
Yersinia pestis (2041 aa), FASTA scores: opt: 2297, E():
5.3e-123,(38.55% identity in 1069 aa overlap);
P48633|HMP2_YEREN|IRP2 high-molecular-weight protein 2
(may be involved in the nonribosomal synthesis of small
peptides) from Yersinia enterocolitica (2035 aa), FASTA
scores: opt: 2275, E(): 9.4e-122, (38.45% identity in 1069
aa overlap); O85739|PCHE|PA4226 dihydroaeruginoic acid
synthetase from Pseudomonas aeruginosa (1438 aa) FASTA
scores: opt: 2236, E(): 1.2e-119, (38.2% identity in 1330
aa overlap); Q9RFM8|PCHE pyochelin synthetase from
Pseudomonas aeruginosa (1438 aa), FASTA scores: opt:
2229,E(): 3e-119, (38.0% identity in 1329 aa overlap);
etc. Contains PS00455 Putative AMP-binding domain
signature, and PS00012 Phosphopantetheine attachment site.
Belongs to the ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv2383c"
/db_xref="EnsemblGenomes-Tr:CCP45171"
/db_xref="GOA:P9WQ63"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR001031"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR010071"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ63"
/inference="protein motif:PROSITE:PS00012"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45171.1"
/translation="MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMS
LVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPL
APMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLP
DGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLL
PGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGYTYREYRQAIEAEETLP
QPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWLDPQTRDALFARARA
RGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVD
LTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGD
LFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTH
QVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFRQAQQQP
DAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILA
AGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEF
VPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADRWLALATL
ECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEV
GGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAAN
LPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTAER
FVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQRLPGVHA
AAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSG
KIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFF
ALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADRLELVAE
VYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAAAAYR
WLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLTAPLTLFGHC
MGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTD
PVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSW
ETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR"
gene 2675936..2677633
/gene="mbtA"
/locus_tag="Rv2384"
CDS 2675936..2677633
/codon_start=1
/transl_table=11
/gene="mbtA"
/locus_tag="Rv2384"
/product="Bifunctional enzyme MbtA: salicyl-AMP ligase
(SAL-AMP ligase) + salicyl-S-ArCP synthetase"
/note="Rv2384, (MTCY22H8.01, MTCY253.37c), len: 565 aa.
mbtA, bifunctional enzyme, including salicyl-AMP ligase
(Sal-AMP ligase) and salicyl-S-ArCP synthetase (see Quadri
et al., 1998; De Voss et al., 1999), highly similar to
other ligases e.g. Q9F638|MXCE from Stigmatella aurantiaca
2,3-DHBA-AMP ligase (protein involved in the biosynthesis
of 2,3-dihydroxybenzoic acid, contains the AMP binding
signature) (543 aa), FASTA scores: opt: 1683, E():
2.8e-90,(48.25% identity in 545 aa overlap) (see
Silakowski et al.,2000); P40871|DHBE_BACSU|ENTE
2,3-dihydroxybenzoate-AMP ligase from Bacillus subtilis
(539 aa), FASTA scores: opt: 1569, E(): 1.2e-83, (44.9%
identity in 532 aa overlap); O07899|VIBE_VIBCHVC0772
vibriobactin-specific 2,3-dihydroxybenzoate-AMP ligase
from Vibrio cholerae (543 aa), FASTA scores: opt: 1457,
E(): 3.7e-77, (44.6% identity in 545 aa overlap); etc.
Also similar to P95819|SNBA pristinamycin I synthetase I
from Streptomyces pristinaespiralis (582 aa), FASTA
scores: opt: 1532, E(): 1.7e-81, (46.35% identity in 548
aa overlap); and Q9RFM9|PCHD salicyl-AMP ligase from
Pseudomonas aeruginosa (547 aa), FASTA scores: opt: 1415,
E(): 1e-74, (45.95% identity in 533 aa overlap). Contains
PS00455 Putative AMP-binding domain signature. Belongs to
the ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv2384"
/db_xref="EnsemblGenomes-Tr:CCP45172"
/db_xref="GOA:P71716"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P71716"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45172.1"
/translation="MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDT
VLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITPGDRVLLQL
PNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPM
ARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTG
MPKLIPRTHDDYVFNATASAALCRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATA
VFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTPKSLRLLQVGGSKLE
PEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNAD
GEPVGPGEEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTG
RVKDVICRAGETIAASDLEEQLLSHPAIFSAAAVGLPDQYLGEKICAAVVFAGAPITL
AELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH"
gene 2677729..2678649
/gene="mbtJ"
/gene_synonym="lipK"
/locus_tag="Rv2385"
CDS 2677729..2678649
/codon_start=1
/transl_table=11
/gene="mbtJ"
/gene_synonym="lipK"
/locus_tag="Rv2385"
/product="Putative acetyl hydrolase MbtJ"
/note="Rv2385, (MTCY253.36c), len: 306 aa. Putative
mbtJ,acetyl hydrolase (see citations below), showing some
similarity with various hydrolases including acetyl
hydrolases e.g. Q9ZBM4|MLCB1450.08|ML0314 putative
hydrolase/esterase from Mycobacterium leprae (335
aa),FASTA scores: opt: 449, E(): 6.7e-21, (33.85% identity
in 313 aa overlap); AAK47950|MT3591 Esterase from M.
tuberculosis strain CDC1551 (327 aa), FASTA scores: opt:
469, E(): 3.6e-22, (35% identity in 283 aa overlap);
Q9X8J4|SCE9.22 putative esterase from Streptomyces
coelicolor (266 aa), FASTA scores: opt: 430,E():
8.5e-20,(38% identity in 245 aa overlap); Q01109|BAH_STRHY
acetyl-hydrolase from Streptomyces hygroscopicus (299
aa),FASTA scores: opt: 420, E(): 4e-19, (35.1% identity in
265 aa overlap). Equivalent to AAK46748 from Mycobacterium
tuberculosis strain CDC1551 (327 aa) but shorter 21 aa.
Note that previously known as lipK."
/db_xref="EnsemblGenomes-Gn:Rv2385"
/db_xref="EnsemblGenomes-Tr:CCP45173"
/db_xref="GOA:Q79FE8"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:Q79FE8"
/protein_id="CCP45173.1"
/translation="MVLRPITGAIPPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQV
NSVLPDGRRVVGEWVYGPHNNAINAGPGGGAIYYVHGSGYTMCSPRTHRRLTSWLSSL
TGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAAEHMVIAADSAGGHLTVDM
LLQPEVAARPPAAVVLFSPLIDLTFRLGASRELQRPDPVVRADRAARSVALYYTGVDP
AHHRLALDVAGGPPLPPTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHVF
QALPRMTPEAAKAMTYVAQFIRSTTARGDL"
gene complement(2678653..2680005)
/gene="mbtI"
/gene_synonym="trpE2"
/locus_tag="Rv2386c"
CDS complement(2678653..2680005)
/codon_start=1
/transl_table=11
/gene="mbtI"
/gene_synonym="trpE2"
/locus_tag="Rv2386c"
/product="Isochorismate synthase MbtI"
/note="Rv2386c, (MTCY253.35), len: 450 aa.
mbtI,isochorismate synthase (see citations below), similar
to Q9X9I8|IRP9 salicylate synthetase from Yersinia
enterocolitica (434 aa), FASTA scores: opt: 887, E():
7.5e-48, (37.45% identity in 422 aa overlap); and similar
in C-terminal region to many anthranilate synthases
component I e.g. Q9Z4W7|TRPE_STRCO|SCE8.07c from
Streptomyces coelicolor (511 aa), FASTA scores: opt:
509,E(): 3e-24, (40.4% identity in 255 aa overlap);
P33975|TRPE_HALVO from Halobacterium volcanii (Haloferax
volcanii) (523 aa) FASTA scores: opt: 488, E():
6.2e-23,(34.2% identity in 298 aa overlap); and similar to
Q08653|TRPE_THEMA|TM0142 anthranilate synthase component I
from Thermotoga maritima (461 aa), FASTA scores: opt:
478,E(): 2.3e-22, (28.4% identity in 440 aa overlap); etc.
Could be belong to the anthranilate synthase component I
family. Note that previously known as trpE2, an
anthranilate synthase component I."
/db_xref="EnsemblGenomes-Gn:Rv2386c"
/db_xref="EnsemblGenomes-Tr:CCP45174"
/db_xref="GOA:P9WFX1"
/db_xref="InterPro:IPR005801"
/db_xref="InterPro:IPR015890"
/db_xref="InterPro:IPR019996"
/db_xref="InterPro:IPR019999"
/db_xref="PDB:2G5F"
/db_xref="PDB:2I6Y"
/db_xref="PDB:3LOG"
/db_xref="PDB:3RV6"
/db_xref="PDB:3RV7"
/db_xref="PDB:3RV8"
/db_xref="PDB:3RV9"
/db_xref="PDB:3ST6"
/db_xref="PDB:3VEH"
/db_xref="UniProtKB/Swiss-Prot:P9WFX1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45174.1"
/translation="MSELSVATGAVSTASSSIPMPAGVNPADLAAELAAVVTESVDED
YLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLE
TDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREA
IDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAI
DFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGR
GPAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQH
LGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVML
SADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
"
gene 2680765..2682018
/locus_tag="Rv2387"
CDS 2680765..2682018
/codon_start=1
/transl_table=11
/locus_tag="Rv2387"
/product="Conserved protein"
/note="Rv2387, (MTCY253.34c), len: 417 aa. Conserved
protein, showing some similarities with others e.g.
Q9K663|BH3869 hypothetical protein from Bacillus
halodurans (337 aa), FASTA scores: opt: 343, E(): 4.8e-14,
(29.0% identity in 400 aa overlap); AAK25471|CC3509
hypothetical protein from Caulobacter crescentus (365 aa),
FASTA scores: opt: 282, E(): 3.2e-10, (32.6% identity in
399 aa overlap); P73953|SLR1512 [D90911_21] conserved
hypothetical protein from Synechocystis sp. strain PCC6803
(374 aa), FASTA scores: opt: 230, E(): 5.5e-07; (24.75%
identity in 408 aa overlap); etc. Contains PS00213
Lipocalin signature."
/db_xref="EnsemblGenomes-Gn:Rv2387"
/db_xref="EnsemblGenomes-Tr:CCP45175"
/db_xref="GOA:P71757"
/db_xref="InterPro:IPR010293"
/db_xref="UniProtKB/TrEMBL:P71757"
/inference="protein motif:PROSITE:PS00213"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45175.1"
/translation="MLHEFWVNFTHNLFKPLLLFFYFGFLIPIFKVRFEFPYVLYQGL
TLYLLLAIGWHGGEELAKIKPSNVGAIVGFMVVGFALNFVIGTLAYFLLSKLTAMRRV
DRATVAGYYGSDSAGTFATCVAVLTSVGMAFDAYMPVMLAVMEIPGCLVALYLVARLR
HRGMNEAGYMADEPGYTTAAMIGAGPGTPARPAHSDSLTAQAERGIEEELELSLEKRE
HPNWDEDGVKDSGTNASIFSRELLQEVFLNPGLVLLFGGIVIGLISGLQGQKVLHDDD
NFFVAAFQGVLCLFLLEMGMTASRKLKDLASAGSGFVFFGLLAPNLFATLGIIVAHGY
AYVTNNDFAPGTYVLFAVLCGAASYIAVPAVQRLAIPEASPTLPLAASLGLTFSYNVT
IGIPLYIEIARIVGQWFPATGASIG"
gene complement(2682015..2683142)
/gene="hemN"
/locus_tag="Rv2388c"
CDS complement(2682015..2683142)
/codon_start=1
/transl_table=11
/gene="hemN"
/locus_tag="Rv2388c"
/product="Probable oxygen-independent coproporphyrinogen
III oxidase HemN (coproporphyrinogenase) (coprogen
oxidase)"
/note="Rv2388c, (MTCY253.33), len: 375 aa. Probable
hemN,oxygen-independent coproporphyrinogen III oxidases,
highly similar to many putative oxygen-independent
coproporphyrinogen III oxidases e.g. Q9RDD2|SCC77.26 from
Streptomyces coelicolor (435 aa), FASTA scores: opt:
1358,E(): 1.5e-76, (56.55% identity in 382 aa overlap);
BAB51237|MLR4627 from Rhizobium loti (Mesorhizobium loti)
(392 aa), FASTA scores: opt: 696, E(): 1.1e-35, (36.8%
identity in 383 aa overlap); Q9KUR0|VC0455 from Vibrio
cholerae (391 aa), FASTA scores: opt: 691, 2.2e-35,
(32.65% identity in 386 aa overlap); P54304|HEMN_BACSU
from Bacillus subtilis (366 aa), FASTA scores: opt: 668 ,
E(): 5.6e-34; (34.9% identity in 327 aa overlap); etc.
Equivalent to AAK46752 from Mycobacterium tuberculosis
strain CDC1551 (390 aa) but shorter 375 aa. Belongs to the
anaerobic coproporphyrinogen III oxidase family."
/db_xref="EnsemblGenomes-Gn:Rv2388c"
/db_xref="EnsemblGenomes-Tr:CCP45176"
/db_xref="GOA:P9WP73"
/db_xref="InterPro:IPR004559"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR023404"
/db_xref="InterPro:IPR034505"
/db_xref="UniProtKB/Swiss-Prot:P9WP73"
/protein_id="CCP45176.1"
/translation="MPGQPFGVYLHVPFCLTRCGYCDFNTYTPAQLGGVSPDRWLLAL
RAELELAAAKLDAPTVHTVYVGGGTPSLLGGERLATLLDMVRDHFVLAPDAEVSTEAN
PESTWPEFFATIRAAGYTRVSLGMQSVAPRVLATLDRVHSPGRAAAAATEAIAEGFTH
VNLDLIYGTPGESDDDLVRSVDAAVQAGVDHVSAYALVVEHGTALARRVRRGELAAPD
DDVLAHRYELVDARLSAAGFAWYEVSNWCRPGGECRHNLGYWDGGQWWGAGPGAHGYI
GVTRWWNVKHPNTYAEILAGATLPVAGFEQLGADALHTEDVLLKVRLRQGLPLARLGA
AERERAEAVLADGLLDYHGDRLVLTGRGRLLADAVVRTLLG"
gene complement(2683248..2683712)
/gene="rpfD"
/locus_tag="Rv2389c"
CDS complement(2683248..2683712)
/codon_start=1
/transl_table=11
/gene="rpfD"
/locus_tag="Rv2389c"
/product="Probable resuscitation-promoting factor RpfD"
/note="Rv2389c, (MTCY253.32), len: 154 aa. Probable
rpfD,resuscitation-promoting factor. Possible autocrine
and/or paracrine bacterial growth factor or cytokine (see
citation below). Similar to others from Mycobacterium
tuberculosis e.g. O07747|Rv1884c|MTCY180.34|RPFC probable
resuscitation-promoting factor from Mycobacterium
tuberculosis (176 aa), FASTA scores: opt: 382, E():
2.3e-17, (55.45% identity in 101 aa overlap); etc. Also
similarity with Q9CBF8|ML2030 hypothetical protein from
Mycobacterium leprae (157 aa), FASTA scores: opt: 397,
E(): 2.4e-18, (47.95% identity in 121 aa overlap);
Q9F2Q2|SCE41.06c putative secreted protein from
Streptomyces coelicolor (244 aa), FASTA scores: opt:
341,E(): 1.1e-14, (40.45% identity in 131 aa overlap); and
O86308|Z96935|MLRPF_1 RPF protein precursor from
Micrococcus luteus (220 aa), FASTA scores: opt: 301, E():
3.6e-12, (39.4% identity in 132 aa overlap). Contains a
secretory signal sequence in N-terminus. Supposed acts at
very low concentration. Predicted possible vaccine
candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2389c"
/db_xref="EnsemblGenomes-Tr:CCP45177"
/db_xref="GOA:P9WG27"
/db_xref="InterPro:IPR010618"
/db_xref="InterPro:IPR023346"
/db_xref="UniProtKB/Swiss-Prot:P9WG27"
/protein_id="CCP45177.1"
/translation="MTPGLLTTAGAGRPRDRCARIVCTVFIETAVVATMFVALLGLST
ISSKADDIDWDAIAQCESGGNWAANTGNGLYGGLQISQATWDSNGGVGSPAAASPQQQ
IEVADNIMKTQGPGAWPKCSSCSQGDAPLGSLTHILTFLAAETGGCSGSRDD"
gene complement(2683709..2684266)
/locus_tag="Rv2390c"
CDS complement(2683709..2684266)
/codon_start=1
/transl_table=11
/locus_tag="Rv2390c"
/product="Conserved hypothetical protein"
/note="Rv2390c, (MTCY253.31), len: 185 aa. Conserved
hypothetical protein, similar to other Mycobacterium
tuberculosis proteins
Q11032|YD62_MYCTU|MTCY02B10.26c|Rv1362c hypothetical 23.5
kDa protein (220 aa), FASTA scores: opt: 223, E():
2.1e-07,(27.4% identity in 190 aa overlap); and
Q11033|YD63_MYCTU|MTCY02B10.27c|Rv1363c hypothetical 28.3
kDa protein (261 aa), FASTA scores: opt: 238, E():
2.7e-08,(27.6% identity in 163 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2390c"
/db_xref="EnsemblGenomes-Tr:CCP45178"
/db_xref="GOA:P71754"
/db_xref="UniProtKB/TrEMBL:P71754"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45178.1"
/translation="MAIFGRGHGASEPGGTGEPAETPGRGRLTRSVIGWVGAVAVVVS
LAGSGWCGWVLFEKHQTDVAAGQALQAARSYVVKLATMDCERIDHNMRDILEGSTGEF
KDKYGKSSAHLRQLLADNRVATHGTVVAASVKSATTNKVVVLMFIDQSVSNRNSPTPQ
IDRSRIKVIMDKVNGRWLASKVELL"
gene 2684679..2686370
/gene="sirA"
/locus_tag="Rv2391"
CDS 2684679..2686370
/codon_start=1
/transl_table=11
/gene="sirA"
/locus_tag="Rv2391"
/product="Ferredoxin-dependent sulfite reductase SirA"
/note="Rv2391, (MTCY253.30c), len: 563 aa.
SirA,ferredoxin-dependent sulfite reductase (See Schnell
et al.,2005). Previously annotated as nirA. Similar to
e.g. CAC33947|SCBAC1A6.26c Putative nitrite/sulphite
reductase from Streptomyces coelicolor (565 aa), FASTA
scores: opt: 2335, E(): 1.2e-137, (60.1% identity in 567
aa overlap); Q9RZD6|DRA0013 ferredoxin-nitrite reductase
from Deinococcus radiodurans (563 aa), FASTA scores: opt:
1141,E(): 2.2e-63, (39.6% identity in 533 aa overlap);
Q59656|NIRA (D31732|PEENIRNRT_1) ferredoxin-dependent
nitrite reductase from Plectonema boryanum (654 aa) (see
Suzuki & Kikuchi 1995), FASTA scores: opt: 805, E():
1.9e-42, (31.7% identity in 517 aa overlap);
Q55366|NIRA|SLR0898 ferredoxin-nitrite reductase from
Synechocystis sp. strain PCC 6803 (502 aa), FASTA scores:
opt: 799, E(): 3.7e-42, (32.3% identity in 517 aa
overlap); etc. Highly similar (only in N-terminal part
because shortened protein (fragment) owing to an IS900
insertion) to Q9K541|NIRA nitrate reductase (fragment)
from Mycobacterium paratuberculosis (198 aa), FASTA
scores: opt: 798, E(): 2.1e-42, (65.4% identity in 182 aa
overlap) (see Bull et al., 2000)."
/db_xref="EnsemblGenomes-Gn:Rv2391"
/db_xref="EnsemblGenomes-Tr:CCP45179"
/db_xref="GOA:P9WJ03"
/db_xref="InterPro:IPR005117"
/db_xref="InterPro:IPR006066"
/db_xref="InterPro:IPR006067"
/db_xref="InterPro:IPR036136"
/db_xref="PDB:1ZJ8"
/db_xref="PDB:1ZJ9"
/db_xref="UniProtKB/Swiss-Prot:P9WJ03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45179.1"
/translation="MSAKENPQMTTARPAKARNEGQWALGHREPLNANEELKKAGNPL
DVRERIENIYAKQGFDSIDKTDLRGRFRWWGLYTQREQGYDGTWTGDDNIDKLEAKYF
MMRVRCDGGALSAAALRTLGQISTEFARDTADISDRQNVQYHWIEVENVPEIWRRLDD
VGLQTTEACGDCPRVVLGSPLAGESLDEVLDPTWAIEEIVRRYIGKPDFADLPRKYKT
AISGLQDVAHEINDVAFIGVNHPEHGPGLDLWVGGGLSTNPMLAQRVGAWVPLGEVPE
VWAAVTSVFRDYGYRRLRAKARLKFLIKDWGIAKFREVLETEYLKRPLIDGPAPEPVK
HPIDHVGVQRLKNGLNAVGVAPIAGRVSGTILTAVADLMARAGSDRIRFTPYQKLVIL
DIPDALLDDLIAGLDALGLQSRPSHWRRNLMACSGIEFCKLSFAETRVRAQHLVPELE
RRLEDINSQLDVPITVNINGCPNSCARIQIADIGFKGQMIDDGHGGSVEGFQVHLGGH
LGLDAGFGRKLRQHKVTSDELGDYIDRVVRNFVKHRSEGERFAQWVIRAEEDDLR"
gene 2686367..2687131
/gene="cysH"
/locus_tag="Rv2392"
CDS 2686367..2687131
/codon_start=1
/transl_table=11
/gene="cysH"
/locus_tag="Rv2392"
/product="Probable 3'-phosphoadenosine 5'-phosphosulfate
reductase CysH (PAPS reductase, thioredoxin DEP.) (padops
reductase) (3'-phosphoadenylylsulfate reductase) (PAPS
sulfotransferase)"
/note="Rv2392, (MTCY253.29c), len: 254 aa. Probable
cysH,3'-phosphoadenosine 5'-phosphosulfate reductase (see
citation below), similar to many e.g.
P94498|O34620|CYH1_BACSU|CYSH from Bacillus subtilis (233
aa), FASTA scores: opt: 618, E(): 8.1e-32, (46.5% identity
in 202 aa overlap); Q9KCT3|CYSH|BH1486 from Bacillus
halodurans (231 aa), FASTA scores: opt: 560, E():
3.6e-28,(41.3% identity in 230 aa overlap);
P56860|CYSH_DEIRA from Deinococcus radiodurans (255 aa),
FASTA scores: opt: 489,E(): 1.1e-23, (44.7% identity in
190 aa overlap); etc. Belongs to the PAPS reductase family
and CYSH subfamily. Note that operon cysA-cysW-cysT-subI,
probably involved in sulfate transport, is near this
putative ORF."
/db_xref="EnsemblGenomes-Gn:Rv2392"
/db_xref="EnsemblGenomes-Tr:CCP45180"
/db_xref="GOA:P9WIK3"
/db_xref="InterPro:IPR002500"
/db_xref="InterPro:IPR004511"
/db_xref="InterPro:IPR011798"
/db_xref="InterPro:IPR014729"
/db_xref="UniProtKB/Swiss-Prot:P9WIK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45180.1"
/translation="MSGETTRLTEPQLRELAARGAAELDGATATDMLRWTDETFGDIG
GAGGGVSGHRGWTTCNYVVASNMADAVLVDLAAKVRPGVPVIFLDTGYHFVETIGTRD
AIESVYDVRVLNVTPEHTVAEQDELLGKDLFARNPHECCRLRKVVPLGKTLRGYSAWV
TGLRRVDAPTRANAPLVSFDETFKLVKVNPLAAWTDQDVQEYIADNDVLVNPLVREGY
PSIGCAPCTAKPAEGADPRSGRWQGLAKTECGLHAS"
gene 2687128..2687973
/gene="che1"
/locus_tag="Rv2393"
CDS 2687128..2687973
/codon_start=1
/transl_table=11
/gene="che1"
/locus_tag="Rv2393"
/product="Ferrochelatase Che1"
/note="Rv2393, (MTCY253.28c), len: 281 aa.
Che1,ferrochelatase (See Pinto et al., 2007). Conserved
protein,with some similarity to Q9L2E8|SC7A8.10c putative
secreted protein from Streptomyces coelicolor (274 aa),
FASTA scores: opt: 407, E(): 2.8e-18, (37% identity in 246
aa overlap); CAC38793|SCI39.05 Conserved hypothetical
protein from Streptomyces coelicolor (305 aa), FASTA
scores: opt: 394, E(): 2e-17, (35.0% identity in 251 aa
overlap); AAK44492|MT0272 Chalcone/stilbene synthase
family protein from Mycobacterium tuberculosis (247 aa),
FASTA scores: opt: 350, E(): 9.2e-15, (34.0% identity in
235 aa overlap); P95216|Rv0259c|MTCY06A4.03c|Z86089
hypothetical protein from Mycobacterium tuberculosis (247
aa), FASTA scores: opt: 345, E(): 1.9e-14,(33.6% identity
in 235 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2393"
/db_xref="EnsemblGenomes-Tr:CCP45181"
/db_xref="GOA:P71751"
/db_xref="InterPro:IPR002762"
/db_xref="UniProtKB/TrEMBL:P71751"
/protein_id="CCP45181.1"
/translation="MTAPATMQSAAMLRSGAIEAPPATMQSAAMRWGHLPLAEESGTI
APQLVLTAHGSKDPRSAANARAIAGRLARMRPGLDVRVAFCELNSPNLVDVLNRCRGA
AVVTPLLLADAYHARVDIPAQIASCRVGHRVRQASVLGEDIRLVSALHERLTELGVSP
FDHTLGVVVLAIGSSHPAANARTSTVASRLAEGTQWAAVTTAFITRPEASLADATDRL
RRHGARRMVIAPWLLAPGILSDRVRGYAREAGIAMAQPLGAHPMVAATMWDRYRQAVA
GRIAA"
repeat_region 2687128..2687179
/gene="che1"
/locus_tag="Rv2393"
/note="52 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region 2687180..2687257
/gene="che1"
/locus_tag="Rv2393"
/note="78 bp Mycobacterial Interspersed Repetitive
Unit,Class I"
gene 2688010..2689941
/gene="ggtB"
/locus_tag="Rv2394"
CDS 2688010..2689941
/codon_start=1
/transl_table=11
/gene="ggtB"
/locus_tag="Rv2394"
/product="Probable gamma-glutamyltranspeptidase precursor
GgtB (gamma-glutamyltransferase) (glutamyl
transpeptidase)"
/note="Rv2394, (MTCY253.27c), len: 643 aa. Probable
ggtB,gamma-glutamyltranspeptidase precursor, similar to
many e.g. Q9KVF2|VC0194 from Vibrio cholerae (588 aa),
FASTA scores: opt: 943, E(): 7.5e-47, (40.0% identity in
597 aa overlap); O69935|SC3C8.26 from Streptomyces
coelicolor (603 aa), FASTA scores: opt: 822, E(): 7.2e-40,
(33.6% identity in 622 aa overlap); P54422|GGT_BACSU from
Bacillus subtilis (587 aa) FASTA scores: opt: 491, E():
8.2e-21, (33.4% identity in 574 aa overlap); etc. Has
potential signal peptide and appropriately positioned
prokaryotic lipoprotein attachment site (PS00013)."
/db_xref="EnsemblGenomes-Gn:Rv2394"
/db_xref="EnsemblGenomes-Tr:CCP45182"
/db_xref="GOA:P71750"
/db_xref="InterPro:IPR029055"
/db_xref="UniProtKB/TrEMBL:P71750"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45182.1"
/translation="MSVWLRAGALVAAVMLSLSGCGGFHAGAPSTAGPCEIVPNGTPA
PKTPPATVPSSRNLATNPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLRDGGT
AADAVVAAQAVLGLVEPQSSGIGGGGYLVYFDARTGSVQAYDGREVAPAAATENYLRW
VSDVDRSAPRPNARASGRSIGVPGILRMLEMVHNEHGRTPWRDLFGPAVTLADGGFDI
SARMGAAISDAAPQLRDDPEARKYFLNPDGSPKPAGTRLTNPAYSKTLSAIASAGANA
FYSGDIAHDIVAAASDTSNGRTPGLLTIEDLAGYLAKRRQPLCTTYRGREICGMPSSG
GVAVAATLGILEHFPMSDYAPSKVDLNGGRPTVMGVHLIAEAERLAYADRDQYIADVD
FVRLPGGSLTTLVDPGYLAARAALISPQHSMGSARPGDFGAPTAVAPPVPEHGTSHLS
VVDSYGNAATLTTTVESSFGSYHLVDGFILNNQLSDFSAEPHATDGSPVANRVEPGKR
PRSSMAPTLVFDHSSAGRGALYAVLGSPGGSMIIQFVVKTLVAMLDWGLNPQQAVSLV
DFGAANSPHTNLGGENPEINTSDDGDHDPLVQGLRALGHRVNLAEQSSGLSAITRSEA
GWAGGADPRREGAVMGDDA"
gene 2690072..2692075
/locus_tag="Rv2395"
CDS 2690072..2692075
/codon_start=1
/transl_table=11
/locus_tag="Rv2395"
/product="Probable conserved integral membrane protein"
/note="Rv2395, (MTCY253.26c), len: 667 aa. Probable
conserved integral membrane protein, similar to
AAK24613|CC2646 oligopeptide transporter/opt family
protein from Caulobacter crescentus (666 aa), FASTA
scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa
overlap); Q9PIS5|CJ0204 putative integral membrane protein
from Campylobacter jejuni (665 aa), FASTA scores: opt:
1484,E(): 2.9e-77, (40.6% identity in 658 aa overlap); and
P44016|Y561_HAEIN hypothetical integral membrane protein
from Haemophilus influenzae (635 aa), FASTA scores: opt:
1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2395"
/db_xref="EnsemblGenomes-Tr:CCP45183"
/db_xref="GOA:P71749"
/db_xref="InterPro:IPR004813"
/db_xref="InterPro:IPR004814"
/db_xref="UniProtKB/TrEMBL:P71749"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45183.1"
/translation="MSGATVGAREITIRGVVLGALITLVFTAANVYLGLRVGLTFATS
IPAAVISMGVLRLFANHSVVENNIVQTIASAAGTLSSIIFVLPALLMIGWWSGFPYWT
TAAVCALGGILGVMYSIPLRRALVTGSDLPYPEGVAGAEVLKIGDSAREMEHNRRGIG
VIALGAAAAAGYALLASLRVINNSLSATFRVGSGATMIGASLSLALIGVGHLVGVTVG
VAMIVGLAIAFGVMLPIRTAGQLPPDGDYAVAVARIFSTDVRFIGAGAIAVAAAWTFL
KILGPILRGIADAAVSARTRRRGQAVGQTERDIPIHIVAMVVLLSLIPIGWLLADFTD
GTPLDDRRPGAIAAGVLLVLVIGLMVAAVCGYMAGLIGSSNSPISGVGILVVVLAGLL
IKTAYGPATGSQIPALVAYTVFTAALVFGVATISNDNLQDLKTGQLVGATPWKQQVAL
IIGVLVGSVVMAPILQLMQAGFGFQGAPGATANALAAPQAALMSALAKGVFGGSLNWS
LVGVGALTGVIAVALDETLAKTTTNLRLPPLAVGMGMYLSAALTLMIPIGAFLGRIYD
SWARWSGDDDERKKRLGVMLATGLIVGESLYGVLFAVIVATTGKEEPLAMVGDGFRFA
SQPLGAIVFAGLLAWLYQRTRVTASYRLAAPAGSSKPLPDLPG"
gene 2692172..2692521
/gene="mcr7"
ncRNA 2692172..2692521
/gene="mcr7"
/product="Putative small regulatory RNA"
/note="mcr7, putative small regulatory RNA (See DiChiara
et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC
Pasteur, 3'-end not mapped."
/ncRNA_class="other"
gene 2692224..2692439
/gene="aprA"
/locus_tag="Rv2395A"
CDS 2692224..2692439
/codon_start=1
/transl_table=11
/gene="aprA"
/locus_tag="Rv2395A"
/product="Acid and phagosome regulated protein A AprA"
/note="Rv2395A, len: 71 aa. AprA, acid and phagosome
regulated protein A, restricted to M. tuberculosis
complex. Note completely overlapped by sRNA mcr7."
/db_xref="EnsemblGenomes-Gn:Rv2395A"
/db_xref="EnsemblGenomes-Tr:CCP45184"
/db_xref="UniProtKB/TrEMBL:V5QPR9"
/protein_id="CCP45184.1"
/translation="MTMTASVAKVTAARPEPSAAWAEARRRVRQRREDMLRHPAFLSK
QLPAEPADDDGVAAVYDIAIARRRRPA"
gene 2692551..2692715
/gene="aprB"
/locus_tag="Rv2395B"
CDS 2692551..2692715
/codon_start=1
/transl_table=11
/gene="aprB"
/locus_tag="Rv2395B"
/product="Acid and phagosome regulated protein B AprB"
/note="Rv2395B, len: 54 aa. AprB, acid and phagosome
regulated protein B, restricted to M. tuberculosis
complex."
/db_xref="EnsemblGenomes-Gn:Rv2395B"
/db_xref="EnsemblGenomes-Tr:CCP45185"
/db_xref="UniProtKB/TrEMBL:V5QRX2"
/protein_id="CCP45185.1"
/translation="MPGLVPAMPLDALRPARQPTSGLGECATMRRPEAGNEKVAVIWE
SLDVVPPESL"
gene 2692799..2693884
/gene="PE_PGRS41"
/gene_synonym="aprC"
/locus_tag="Rv2396"
CDS 2692799..2693884
/codon_start=1
/transl_table=11
/gene="PE_PGRS41"
/gene_synonym="aprC"
/locus_tag="Rv2396"
/product="PE-PGRS family protein PE_PGRS41"
/note="Rv2396, (MTCY253.25c), len: 361 aa.
PE_PGRS41,member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below). Also known as aprC, acid and phagosome regulated
protein C,restricted to M. tuberculosis complex (See
Abramovitch et al., 2011). Contains PS00583 pfkB family of
carbohydrate kinases signature 1. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2396"
/db_xref="EnsemblGenomes-Tr:CCP45186"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FE6"
/inference="protein motif:PROSITE:PS00583"
/protein_id="CCP45186.1"
/translation="MSFLIASPEALAATATYLTGIGSAISAANAVAAAPTTEILAAGT
DEVSTAISALFGAHAQAYQALSAHVAAFHDQFVHTLTAGAGSYMAAEAAAASPLQALQ
LELLNAINAPTLALLGRPLIGDGTDAAPGSGGAGGAGGILIGNGGTGGASDLAGTGRG
GVGGAGGAGGLFGIGGAGGGCGSAVAIGGDGGAGGAGGVFSGGGAGGAGDAIGGSGGA
GGTGGLLGGGGGAGGAGGAGGNGGGASNSASIGGDGGSGGAGGMLYGAGGVGGNGGAA
VAIGGDGGAGGRAGAIGNGGDGGNGGTSNTPGGSGGDGGNGGNAGLIGNGGNGGNAEI
VISGGSVAGTGGNGGLLLGFNGTNGLP"
gene complement(2693909..2694964)
/gene="cysA1"
/gene_synonym="cysA"
/locus_tag="Rv2397c"
CDS complement(2693909..2694964)
/codon_start=1
/transl_table=11
/gene="cysA1"
/gene_synonym="cysA"
/locus_tag="Rv2397c"
/product="Sulfate-transport ATP-binding protein ABC
transporter CysA1"
/note="Rv2397c, (MTCY253.24), len: 351 aa.
cysA1,sulfate-transport ATP-binding protein ABC
transporter (see citations below), similar to other
sulfate ABC transporter ATP-binding proteins e.g.
P14788|CYSA_SYNP7 from Synechococcus sp. (344 aa), FASTA
scores: opt: 1112, E(): 2.6e-56, (54.6% identity in 328 aa
overlap); P74548|CYSA_SYNY3 from Synechocystis sp. (355
aa), FASTA scores: opt: 1063, E(): 1.7e-53, (51.9%
identity in 343 aa overlap); Q9I6L0|CYSA|PA0280 from
Pseudomonas aeruginosa (329 aa), FASTA scores: opt: 987,
E(): 3.3e-49, (49.2% identity in 339 aa overlap); etc.
Also similar to many ATP-binding proteins from
Mycobacterium tuberculosis e.g. Rv2038c, Rv1238, Rv2832c,
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop), and PS00211 ABC transporters family signature.
Belongs to the ATP-binding transport protein family (ABC
transporters). Note that previously known as cysA."
/db_xref="EnsemblGenomes-Gn:Rv2397c"
/db_xref="EnsemblGenomes-Tr:CCP45187"
/db_xref="GOA:P9WQM1"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005666"
/db_xref="InterPro:IPR008995"
/db_xref="InterPro:IPR014769"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR024765"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQM1"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45187.1"
/translation="MTYAIVVADATKRYGDFVALDHVDFVVPTGSLTALLGPSGSGKS
TLLRTIAGLDQPDTGTITINGRDVTRVPPQRRGIGFVFQHYAAFKHLTVRDNVAFGLK
IRKRPKAEIKAKVDNLLQVVGLSGFQSRYPNQLSGGQRQRMALARALAVDPEVLLLDE
PFGALDAKVREELRAWLRRLHDEVHVTTVLVTHDQAEALDVADRIAVLHKGRIEQVGS
PTDVYDAPANAFVMSFLGAVSTLNGSLVRPHDIRVGRTPNMAVAAADGTAGSTGVLRA
VVDRVVVLGFEVRVELTSAATGGAFTAQITRGDAEALALREGDTVYVRATRVPPIAGG
VSGVDDAGVERVKVTST"
gene complement(2694981..2695799)
/gene="cysW"
/locus_tag="Rv2398c"
CDS complement(2694981..2695799)
/codon_start=1
/transl_table=11
/gene="cysW"
/locus_tag="Rv2398c"
/product="Probable sulfate-transport integral membrane
protein ABC transporter CysW"
/note="Rv2398c, (MTCY253.23), len: 272 aa. Probable
cysW,sulfate-transport integral membrane protein ABC
transporter (see citations below), similar to others e.g.
Q9K877|CYSW|BH3129 sulfate ABC transporter (permease) from
Bacillus halodurans (287 aa), FASTA scores: opt: 765, E():
4.1e-40, (43.8% identity in 249 aa overlap);
P27370|CYSW_SYNP7 sulfate transport system (permease)
protein from Synechococcus sp. strain PCC 7942 (Anacystis
nidulans R2) (286 aa), FASTA scores: opt: 757, E():
1.3e-39, (44.3% identity in 264 aa overlap);
Q9I6K9|CYSW|PA0281 sulfate transport protein from
Pseudomonas aeruginosa (289 aa), FASTA scores: opt:
753,E(): 2.3e-39, (44.4% identity in 250 aa overlap);
P16702|P76534|CYSW_ECOLI sulfate transport system permease
from Escherichia coli (291 aa), FASTA scores: opt:
633,E(): 5.7e-32, (38.2% identity in 267 aa overlap); etc.
Contains PS00402 Binding-protein-dependent transport
systems inner membrane component signature. Similarity
with integral membrane components of other
binding-protein-dependent transport systems and belongs to
the CYSTW subfamily."
/db_xref="EnsemblGenomes-Gn:Rv2398c"
/db_xref="EnsemblGenomes-Tr:CCP45188"
/db_xref="GOA:P71746"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR005667"
/db_xref="InterPro:IPR011866"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:P71746"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP45188.1"
/translation="MTSLPAARYLVRSVALGYVFVLLIVPVALILWRTFEPGFGQFYA
WISTPAAISALNLSLLVVAIVVPLNVIFGVTTALVLARNRFRGKGVLQAIIDLPFAVS
PVIVGVSLILLWGSAGALGFVEQDLGFKIIFGLPGIVLGSMFVTCPFVVREVEPVLHE
LGTDQEQAAATLGSGWWQTFWRITLPSIRWGLTYGIVLTVARTLGEYGAVIIVSSNLP
GTSQTLTLLVSDRYHRGAEYGAYALSTLLMAVSVVVLIVQMVLDARRARAVSEG"
gene complement(2695796..2696647)
/gene="cysT"
/locus_tag="Rv2399c"
CDS complement(2695796..2696647)
/codon_start=1
/transl_table=11
/gene="cysT"
/locus_tag="Rv2399c"
/product="Probable sulfate-transport integral membrane
protein ABC transporter CysT"
/note="Rv2399c, (MTCY253.22), len: 283 aa. Probable
cysT,sulfate-transport integral membrane protein ABC
transporter (see citations below), similar to others e.g.
BAB48989|MLR1667 permease protein of sulfate ABC
transporter from Rhizobium loti (283 aa), FASTA scores:
opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa
overlap); Q9K878|cyst|BH3128 sulfate ABC transporter
(permease) from Bacillus halodurans (279 aa), FASTA
scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa
overlap); P16701|CYST_ECOLI|CYSU|cyst|B2424 from
Escherichia coli (277 aa), FASTA scores: opt: 669, E():
1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains
PS00402 Binding-protein-dependent transport systems inner
membrane component signature, and PS00017 ATP/GTP-binding
site motif A (P-loop). Belongs to the CYSTW subfamily."
/db_xref="EnsemblGenomes-Gn:Rv2399c"
/db_xref="EnsemblGenomes-Tr:CCP45189"
/db_xref="GOA:P71745"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR005667"
/db_xref="InterPro:IPR011865"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:P71745"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP45189.1"
/translation="MTESLVGERRAPQFRARLSGPAGPPSVRVGMAVVWLSVIVLLPL
AAIVWQAAGGGWRAFWLAVSSHAAMESFRVTLTISTAVTVINLVFGLLIAWVLVRDDF
AGKRIVDAIIDLPFALPTIVASLVMLALYGNNSPVGLHFQHTATGVGVALAFVTLPFV
VRAVQPVLLEIDRETEEAAASLGANGAKIFTSVVLPSLTPALLSGAGLAFSRAIGEFG
SVVLIGGAVPGKTEVSSQWIRTLIENDDRTGAAAISVVLLSISFIVLLILRVVGARAA
KREEMAA"
gene complement(2696644..2697714)
/gene="subI"
/locus_tag="Rv2400c"
CDS complement(2696644..2697714)
/codon_start=1
/transl_table=11
/gene="subI"
/locus_tag="Rv2400c"
/product="Probable sulfate-binding lipoprotein SubI"
/note="Rv2400c, (MTCY253.21), len: 356 aa. Probable
subI,sulfate-binding lipoprotein component of sulfate
transport system (see citations below), equivalent to
Q9CCN3|SUBI|ML0615 (alias Q49748|B1937_F1_11, 358 aa)
putative sulphate-binding protein from Mycobacterium
leprae (348 aa), FASTA scores: opt: 1775, E(): 2.3e-102,
(76.45% identity in 340 aa overlap). Also similar to
others and other substrate-binding proteins e.g.
P27366|SUBI_SYNP7|SBPA sulfate-binding protein precursor
from Synechococcus sp. strain PCC 7942 (Anacystis nidulans
R2) (350 aa), FASTA scores: opt: 703, E(): 4.6e-36, (35.6%
identity in 351 aa overlap); Q9I6K7|SBP|PA0283
sulfate-binding protein precursor from Pseudomonas
aeruginosa (332 aa), FASTA scores: opt: 591, E():
3.7e-29,(36.9% identity in 317 aa overlap);
CAC49112|SMB21133 putative sulfate uptake ABC transporter
periplasmic solute-binding protein precursor from
Rhizobium meliloti (Sinorhizobium meliloti) (341 aa),
FASTA scores: opt: 569,E(): 8.8e-28, (36.15% identity in
321 aa overlap); etc. Belongs to the prokaryotic sulfate
binding protein family."
/db_xref="EnsemblGenomes-Gn:Rv2400c"
/db_xref="EnsemblGenomes-Tr:CCP45190"
/db_xref="GOA:P71744"
/db_xref="InterPro:IPR005669"
/db_xref="PDB:6DDN"
/db_xref="UniProtKB/TrEMBL:P71744"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45190.1"
/translation="MLSLTLSEASCIASASRWRHIIPAGVVCALIAGIGVGCHGGPSD
VVGRAGPDRAHTSITLVAYAVPEPGWSAVIPAFNASEQGRGVQVITSYGASADQSRGV
ADGKPADLVNFSVEPDIARLVKAGKVDKDWDADATKGIPFGSVVTFVVRAGNPKNIRD
WDDLLRPGIEVITPSPLSSGSAKWNLLAPYAAKSDGGRNNQAGIDFVNTLVNEHVKLR
PGSGREATDVFVQGSGDVLISYENEAIATERAGKPVQHVTPPQTFKIENPLAVVATST
HLGAATAFRNFQYTVQAQKLWAQAGFRPVDPAVAADFADLFPVPAKLWTIADLGGWGS
VDPQLFDKATGSITKIYLRATG"
gene 2697728..2698057
/locus_tag="Rv2401"
CDS 2697728..2698057
/codon_start=1
/transl_table=11
/locus_tag="Rv2401"
/product="Hypothetical protein"
/note="Rv2401, (MTCY253.19c), len: 109 aa. Hypothetical
unknown protein. Equivalent to AAK46768 from Mycobacterium
tuberculosis strain CDC1551 (134 aa) but shorter 25 aa.
N-terminus extended since first submission (previously 72
aa)."
/db_xref="EnsemblGenomes-Gn:Rv2401"
/db_xref="EnsemblGenomes-Tr:CCP45191"
/db_xref="GOA:O86326"
/db_xref="UniProtKB/TrEMBL:O86326"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45191.1"
/translation="MRDFGQRSRSGGKAIAEHCRTHELHIRPRTGGESATTVQVGRSA
ANERADIAPRKTRCCVHVAKPNRIRLADQLARSSMGEKPGHDHQRNQRDQNQRDVRPR
HPGYLGA"
gene complement(2698042..2698245)
/locus_tag="Rv2401A"
CDS complement(2698042..2698245)
/codon_start=1
/transl_table=11
/locus_tag="Rv2401A"
/product="Possible conserved membrane protein"
/note="Rv2401A, len: 67 aa. Possible conserved membrane
protein, highly similar, but with 29 aa shorter, to
ML0614|AL583919_34|Q49760 from Mycobacterium leprae (95
aa), FASTA scores: opt: 297, E(): 3.6e-15, (67.7% identity
in 65 aa overlap). Has hydrophobic stretch."
/db_xref="EnsemblGenomes-Gn:Rv2401A"
/db_xref="EnsemblGenomes-Tr:CCP45192"
/db_xref="GOA:Q79FE4"
/db_xref="UniProtKB/TrEMBL:Q79FE4"
/protein_id="CCP45192.1"
/translation="MGPMNGFLSWWDGVELWLSGLPFALQALAVMPVVLALAYFTAAL
LDALLGRVIQLIRRARRPDQAPR"
gene 2698529..2700457
/locus_tag="Rv2402"
CDS 2698529..2700457
/codon_start=1
/transl_table=11
/locus_tag="Rv2402"
/product="Conserved protein"
/note="Rv2402, (MTCY253.18c), len: 642 aa. Conserved
protein, highly similar to others e.g. 9X8C4|SCE36.11c
conserved hypothetical protein (fragment) from
Streptomyces coelicolor (612 aa), FASTA scores: opt: 1283,
E(): 6.5e-75,(41.9% identity in 623 aa overlap);
Q9RJ38|SCI8.15 hypothetical 66.3 KDA protein from
Streptomyces coelicolor (595 aa), FASTA scores: opt: 1152,
E(): 1.7e-66, (39.9% identity in 622 aa overlap),
Q9S223|CI51.17 hypothetical 68.4 KDA protein from
Streptomyces coelicolor (612 aa),FASTA scores: opt: 1146,
E(): 4.2e-66, (40.6% identity in 623 aa overlap);
YAY3_SCHPO|Q10211|c4h3.03c hypothetical 74.5 kDa protein
from Schizosaccharomyces pombe (Fission yeast) (649 aa)
FASTA scores: opt: 999, E(): 1.3e-56,(35.0% identity in
642 aa overlap); etc. Contains possible helix-turn-helix
motif, at aa 224-245 (+4.68 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2402"
/db_xref="EnsemblGenomes-Tr:CCP45193"
/db_xref="GOA:P71741"
/db_xref="InterPro:IPR008928"
/db_xref="InterPro:IPR011613"
/db_xref="InterPro:IPR012341"
/db_xref="UniProtKB/Swiss-Prot:P71741"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45193.1"
/translation="MALSSSSPLRNPFPPIADYAFLSDWETTCLISPAGSVEWLCVPR
PDSPSVFGAILDRSAGHFRLGPYGVSVPSARRYLPGSLIMETTWQTHTGWLIVRDALV
MGKWHDIERRSRTHRRTPMDWDAEHILLRTVRCVSGTVELMMSCEPAFDYHRLGATWE
YSAEAYGEAIARANTEPDAHPTLRLTTNLRIGLEGREARARTRMKEGDDVFVALSWTK
HPPPQTYDEAADKMWQTTECWRQWINIGNFPDHPWRAYLQRSALTLKGLTYSPTGALL
AASTTSLPETPRGERNWDYRYAWIRDSTFALWGLYTLGLDREADDFFAFIADVSGANN
NERHPLQVMYGVGGERSLVEAELHHLSGYDHARPVRIGNGAYNQRQHDIWGSILDSFY
LHAKSREQVPENLWPVLKRQVEEAIKHWREPDRGIWEVRGEPQHFTSSKVMCWVALDR
GAKLAERQGEKSYAQQWRAIADEIKADILEHGVDSRGVFTQRYGDEALDASLLLVVLT
RFLPPDDPRVRNTVLAIADELTEDGLVLRYRVHETDDGLSGEEGTFTICSFWLVSALV
EIGEVGRAKRLCERLLSFASPLLLYAEEIEPRSGRHLGNFPQAFTHLALINAVVHVIR
AEEEADSSGMFQPANAPM"
gene complement(2700535..2701290)
/gene="lppR"
/locus_tag="Rv2403c"
CDS complement(2700535..2701290)
/codon_start=1
/transl_table=11
/gene="lppR"
/locus_tag="Rv2403c"
/product="Probable conserved lipoprotein LppR"
/note="Rv2403c, (MTCY253.17), len: 251 aa. Probable
lppR,conserved lipoprotein, with weak similarity with
mycobacterial serine/threonine protein kinases e.g.
AAK45563|MT1304 from Mycobacterium tuberculosis strain
CDC1551 (626 aa), FASTA scores: opt: 186, E():
0.00023,(24.4% identity in 238 aa overlap), and the
C-terminal part of Q11053|Rv1266c|MTCY50.16|PKNH_MYCTU
from Mycobacterium tuberculosis (626 aa), FASTA scores:
opt: 185, E()= 0.00027, (24.35% identity in 238 aa
overlap). Has signal peptide and appropriate positioned
prokaryotic lipoprotein attachment site (PS00013). Could
belong to the Ser/Thr family of protein kinases."
/db_xref="EnsemblGenomes-Gn:Rv2403c"
/db_xref="EnsemblGenomes-Tr:CCP45194"
/db_xref="InterPro:IPR026954"
/db_xref="InterPro:IPR038232"
/db_xref="UniProtKB/TrEMBL:P71740"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45194.1"
/translation="MTNRWRWVVPLFAVFLAAGCTTTTTGKAGLAPNAVPRPLMGSLI
QRVPLDGAALSTLLNQPFQALPPFPPVFGGSDSLGDSDVSARPADCVGVGYLTQRNVY
RSVEVKSVARVSWRHDGSSVKVDDVDEGVVALPSAAAADDLFARFSAQWKECDGTTLT
VPASAFGQRSITDVRVADSVVAATVSLRRGTHSILASVPQARAVGVRGNCVVEVAVTF
FGITHPSDQGSADISTSAVDIAHAMMDRISELS"
gene complement(2701287..2703248)
/gene="lepA"
/locus_tag="Rv2404c"
CDS complement(2701287..2703248)
/codon_start=1
/transl_table=11
/gene="lepA"
/locus_tag="Rv2404c"
/product="Probable GTP-binding protein LepA (GTP-binding
elongation factor)"
/note="Rv2404c, (MT2476, MTCY253.16), len: 653 aa.
Probable lepA, GTP-binding protein (a protein of unknown
function,but apparently with membrane-related functions
and very similar to protein synthesis elongation factors;
see citations below). Equivalent to
P53530|LEPA_MYCLE|ML0611|B1937_F3_81 GTP-binding protein
from Mycobacterium leprae (646 aa), FASTA scores: opt:
3610, E(): 1.2e-205, (88.0% identity in 649 aa overlap).
Also highly similar to many GTP-binding proteins LEPA e.g.
Q9RDC9|LEPA_STRCO|SCC77.29c from Streptomyces coelicolor
(622 aa), FASTA scores: opt: 3046, E(): 2.3e-172, (74.3%
identity in 626 aa overlap); P37949|LEPA_BACSU from B.
subtilis (612 aa), FASTA scores: opt: 2430, E():
5.3e-136,(58.7% identity in 610 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop), and PS00301
GTP-binding elongation factors signature. Belongs to the
GTP-binding elongation factor family, LEPA subfamily."
/db_xref="EnsemblGenomes-Gn:Rv2404c"
/db_xref="EnsemblGenomes-Tr:CCP45195"
/db_xref="GOA:P9WK97"
/db_xref="InterPro:IPR000640"
/db_xref="InterPro:IPR000795"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR006297"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR013842"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031157"
/db_xref="InterPro:IPR035647"
/db_xref="InterPro:IPR035654"
/db_xref="InterPro:IPR038363"
/db_xref="UniProtKB/Swiss-Prot:P9WK97"
/inference="protein motif:PROSITE:PS00301"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45195.1"
/translation="MRTPCSQHRRDRPSAIGSQLPDADTLDTRQPPLQEIPISSFADK
TFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQYLDRMDIERERGITI
KAQNVRLPWRVDKTDYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAAQGIEAQTL
ANLYLALDRDLHIIPVLNKIDLPAADPDRYAAEMAHIIGCEPAEVLRVSGKTGEGVSD
LLDEVVRQVPPPQGDAEAPTRAMIFDSVYDIYRGVVTYVRVVDGKISPRERIMMMSTG
ATHELLEVGIVSPEPKPCEGLGVGEVGYLITGVKDVRQSKVGDTVTSLSRARGAAAEA
LTGYREPKPMVYSGLYPVDGSDYPNLRDALDKLQLNDAALTYEPETSVALGFGFRCGF
LGLLHMEITRERLEREFGLDLISTSPNVVYRVHKDDGTEIRVTNPSDWPEGKIRTVYE
PVVKTTIIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYTMPLGEIIFDFFDAL
KSRTRGYASLDYEEAGEQEAALVKVDILLQGEAVDAFSAIVHKDTAYAYGNKMTTKLK
ELIPRQQFEVPVQAAIGSKIIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKR
MKTIGRVEVPQEAFVAALSTDAAGDKGKK"
gene 2703269..2703838
/locus_tag="Rv2405"
CDS 2703269..2703838
/codon_start=1
/transl_table=11
/locus_tag="Rv2405"
/product="Conserved protein"
/note="Rv2405, (MTCY253.15c), len: 189 aa. Conserved
protein, identical (but N-terminus longer 40 residues) to
AAK46773|MT2477 hypothetical protein from Mycobacterium
tuberculosis strain CDC1551. Also highly similar, but
N-terminus longer 38 residues, to Q9RD03|SCCM1.41
hypothetical 17.4 KDA protein from Streptomyces coelicolor
(154 aa), FASTA scores: opt: 451, E(): 2e-22, (48.7%
identity in 154 aa overlap). Shows also similarity with
hypothetical proteins from other species."
/db_xref="EnsemblGenomes-Gn:Rv2405"
/db_xref="EnsemblGenomes-Tr:CCP45196"
/db_xref="GOA:P71738"
/db_xref="InterPro:IPR003477"
/db_xref="UniProtKB/TrEMBL:P71738"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45196.1"
/translation="MQRFAENLVFTEAPKLVRHLQNTQETLRTIRQAVKITANIMTTA
VPSPPAEIAAGRPVTSTSCPTAARARRLVYAPDLDGRADPGEIVWTWVAYEQDPTRGK
DRPVLVVGRDRSVLLGLLVSSQERHAADRDWVGIGSGAWDYEGRESWVRLDRVLDVPE
ESIRREGAILEREVFDVVAARLRADYAWR"
gene complement(2704009..2704437)
/locus_tag="Rv2406c"
CDS complement(2704009..2704437)
/codon_start=1
/transl_table=11
/locus_tag="Rv2406c"
/product="Conserved protein"
/note="Rv2406c, (MTCY253.14), len: 142 aa. Conserved
protein. C-terminal region is identical with many CBS
domain protein e.g. AAK46774|MT2478 CBS domain protein
from Mycobacterium tuberculosis strain CDC1551 (aa
47-142),FASTA scores: opt: 594, E(): 1.9e-30, (98.97%
identity in 97 aa overlap); etc. Also similar to other
hypothetical proteins e.g. AAK24594|CC2626 CBS domain
protein from Caulobacter crescentus (157 aa), FASTA
scores: opt: 377,E(): 8.3e-17, (42.55% identity in 141 aa
overlap); BAB47826|MLR0188 from Rhizobium loti; etc."
/db_xref="EnsemblGenomes-Gn:Rv2406c"
/db_xref="EnsemblGenomes-Tr:CCP45197"
/db_xref="InterPro:IPR000644"
/db_xref="UniProtKB/TrEMBL:P71737"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45197.1"
/translation="MRIADVLRNKGAAVVTINPDATVGELLAGLAEQNIGAMVVVGAE
GVVGIVSERDVVRQLHTYGASVLSRPVAKIMSTTVATCTKSDTVDKISVLMTENRVRH
VPVLDGKKLIGIVSIGDVVKSRMGELEAEQQQLQSYITQG"
gene 2704697..2705518
/locus_tag="Rv2407"
CDS 2704697..2705518
/codon_start=1
/transl_table=11
/locus_tag="Rv2407"
/product="Conserved hypothetical protein"
/note="Rv2407, (MTCY253.13c), len: 273 aa. Conserved
hypothetical protein, highly similar (but longer at
N-terminus) to AAK46775|MT2479 putative arylsulfatase from
Mycobacterium tuberculosis strain CDC1551 (224 aa) FASTA
scores: opt: 1433, E(): 2.5e-81, (96.43% identity in 224
aa overlap); O33130|MLCL536.01 hypothetical protein from
Mycobacterium leprae (220 aa), FASTA scores: opt: 658,
E(): 1.5e-33, (56.75% identity in 215 aa overlap). Also
similar to AAK23160|CC1176 Metallo-beta-lactamase family
protein from Caulobacter crescentus (317 aa), FASTA
scores: opt: 286, E(): 1.8e-10, (33% identity in 291 aa
overlap). And similar to other hypothetical proteins eg
Q49744|B1937_C1_163 hypothetical 22.6 KDA protein
(precursor) from Mycobacterium leprae (211 aa), FASTA
scores: opt: 623, E(): 2.1e-31, (56.3% identity in 206 aa
overlap); O27859|MTH1831 conserved protein from
Methanothermobacter thermautotrophicus (307 aa), FASTA
scores: opt: 268, E(): 2.3e-09, (28.35% identity in 307 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2407"
/db_xref="EnsemblGenomes-Tr:CCP45198"
/db_xref="GOA:P9WGZ5"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR013471"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/Swiss-Prot:P9WGZ5"
/protein_id="CCP45198.1"
/translation="MLEITLLGTGSPIPDPDRAGPSTLVRAGAQAFLVDCGRGVLQRA
AAVGVGAAGLSAVLLTHLHGDVLITSWVTNFAADPAPLPIIGPPGTAEVVEATLKAFG
HDIGYRIAHHADLTTPPPIEVHEYTAGPAWDRDGVTIRVAPTDHRPVTPTIGFRIESD
GASVVLAGDTVPCDSLDQLAAGADALVHTVIRKDIVTQIPQQRVKDICDYHSSVQEAA
ATANRAGVGTLVMTHYVPAIGPGQEEQWRALAATEFSGRIEVGNDLHRVEVHPRR"
gene 2706017..2706736
/gene="PE24"
/locus_tag="Rv2408"
CDS 2706017..2706736
/codon_start=1
/transl_table=11
/gene="PE24"
/locus_tag="Rv2408"
/product="Possible PE family-related protein PE24"
/note="Rv2408, (MTCY253.12c), len: 239 aa. Possibly PE24,
a member of PE family (see citation below), similar to
AAK46440|MT2159 from Mycobacterium tuberculosis strain
CDC1551 (491 aa) FASTA scores: opt: 269, E():
5.4e-08,(38.45% identity in 156 aa overlap) and
AAK45466|MT1209 from Mycobacterium tuberculosis strain
CDC1551 (308 aa),FASTA scores: opt: 265, E(): 6.3e-08,
(36.0% identity in 197 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2408"
/db_xref="EnsemblGenomes-Tr:CCP45199"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FE3"
/protein_id="CCP45199.1"
/translation="MLIARPDILCSRGPEAMRAKAADLDLAAAAKTVGVQPAADQVAA
AIAAILLSHAQIYQDISTQMAAFHDQLVENRTADSTSYASAEANAQQSLLNAMDAPSW
QQRRETVGEVGLPADPAGSGTATAAVAAATTARAGSRSAAQATVAPIGGLKLRRESAL
SQPGDLHHHVEVGDALPRVDPFQRGNVGVVAAYTHTDVLLGDLIVIGGVVVPPSTGPG
LNPGMAAPVYRLSHHGITLRV"
gene complement(2706494..2707333)
/locus_tag="Rv2409c"
CDS complement(2706494..2707333)
/codon_start=1
/transl_table=11
/locus_tag="Rv2409c"
/product="Conserved protein"
/note="Rv2409c, (MTCY253.11), len: 279 aa. Conserved
protein, equivalent to
Q49757|YP69_MYCLE|G466976|B1937_F2_39 hypothetical protein
from Mycobacterium leprae (279 aa), FASTA scores: opt:
1564, E(): 4.6e-95, (82.1% identity in 279 aa overlap).
Also similar to others e.g. Q9RSX6|DR1993 from Deinococcus
radiodurans (274 aa), FASTA scores: opt: 494, E():
4e-25,(35.1% identity in 282 aa overlap); BAB49898|Mll2875
from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA
scores: opt: 382, E(): 8.9e-18, (29.75% identity in 269 aa
overlap); Q9I305|PA1732 from Pseudomonas aeruginosa (266
aa), FASTA scores: opt: 326, E(): 3.7e-14, (31.25%
identity in 275 aa overlap); etc. Also similar to
Rv2569c|MTCY227.32 from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv2409c"
/db_xref="EnsemblGenomes-Tr:CCP45200"
/db_xref="GOA:P71734"
/db_xref="InterPro:IPR002931"
/db_xref="InterPro:IPR013589"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/TrEMBL:P71734"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45200.1"
/translation="MWRTRVVHTTGYVYQSPVTASYNEARLTPRSSSRQNLVLNRVET
IPATRSYRYIDYWGTAVTAFDLHAPHTELTVTSSSVVETERPEPLAAKATWADLQSTA
VIDRFDEVLRPTPHTPASARVDAVGRRIRKCHEPSEAVVAAARWARSELDYIPGTTSV
HSSGLDALEQGKGVCQDFVHLSLMVLRSMGIPCRYVSGYLHPKRDAVVGKTVDGRSHA
WVQAWTGGWWHYDPTNDNEITEQYISVGVGRDYTDVSPLKGIYSGEGVTDLDVVVEIT
RLA"
gene complement(2707333..2708310)
/locus_tag="Rv2410c"
CDS complement(2707333..2708310)
/codon_start=1
/transl_table=11
/locus_tag="Rv2410c"
/product="Conserved protein"
/note="Rv2410c, (MTCY253.10), len: 325 aa. Conserved
protein, equivalent to Q49770|CAC30114|ML0606 conserved
hypothetical protein from Mycobacterium leprae (325
aa),FASTA scores: opt: 1928, E(): 3.5e-117, (90.75%
identity in 325 aa overlap). Also some similarity with
other hypothetical proteins e.g. Q9RST2|DR2041 conserved
hypothetical protein from Deinococcus radiodurans (316
aa),FASTA scores: opt: 329, E(): 5.3e-14, (32.4% identity
in 318 aa overlap); C-terminus of Q9HUN7|PA4927
hypothetical protein from Pseudomonas aeruginosa (830 aa),
FASTA scores: opt: 297, E(): 1.5e-11, (27.6% identity in
315 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2410c"
/db_xref="EnsemblGenomes-Tr:CCP45201"
/db_xref="InterPro:IPR007296"
/db_xref="UniProtKB/TrEMBL:P71733"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45201.1"
/translation="MLARNAEALYWIGRYVERADDTARILDVAVHQLLEDSSVDPDQA
SRLLLRVLGIEPPDHELDVWSLTDLVAFSTNSQGGSSIVDAISAARENAKSAREVTSS
ETWECLNTTYNALPERERAAKRLGPHEFLSFIEGRAAMFAGLADSTLLRDDGYRFMLL
GRAIERVDMTVRLLLSRVGDSASSPAWVTLLRSAGAHDTYLRTYRGVLDAGRVVEFMM
LDRLFPRSVFHSLKLAEHNLAELMHNPHSRIGATTEAQRLLGQARSELEFVQPGVLLE
TLESRLAGLQTTCRDVGDALALQYFHAAPWVAWSDAGQRGQLVGSQEES"
gene complement(2708310..2709965)
/locus_tag="Rv2411c"
CDS complement(2708310..2709965)
/codon_start=1
/transl_table=11
/locus_tag="Rv2411c"
/product="Conserved hypothetical protein"
/note="Rv2411c, (MTCY253.09c), len: 551 aa. Hypothetical
protein, highly similar to
Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4
hypothetical 61.8 KDA protein from Mycobacterium leprae
(561 aa), FASTA scores, opt: 3163, E(): 4.1e-178, (87.35%
identity in 554 aa overlap). Also highly similar, except
in N-terminus, to others e.g. Q55587|Y335_SYNY3|SLL0335
hypothetical protein from Synechocystis sp. strain PCC
6803 (481 aa), FASTA scores: opt: 1620, E(): 1.2e-87,
(52.8% identity in 468 aa overlap); Q9I307|PA1730
hypothetical protein from Pseudomonas aeruginosa (470 aa),
FASTA scores: opt: 1574, E(): 5.8e-85, (52.7% identity in
467 aa overlap); Q9RST1|DR2042 conserved hypothetical
protein from Deinococcus radiodurans (655 aa), FASTA
scores: opt: 1561,E(): 4.4e-84, (53.3% identity in 467 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2411c"
/db_xref="EnsemblGenomes-Tr:CCP45202"
/db_xref="InterPro:IPR007302"
/db_xref="InterPro:IPR016450"
/db_xref="UniProtKB/Swiss-Prot:P9WLA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45202.1"
/translation="MRRVSLPNQLNETRRRSPTRGERIFGGYNTSDVYAMAFDEMFDA
QGIVRGPYKGIYAELAPSDASELKARADALGRAFIDQGITFSLSGQERPFPLDLVPRV
ISAPEWTRLERGITQRVKALECYLDDIYGDQEILRDGVIPRRLVTSCEHFHRQAVGIV
PPNGVRIHVAGIDLIRDHRGDFRVLEDNLRSPSGVSYVMENRRTMARVFPNLFATHRV
RAVDDYASHLLRALRNSAATNEADPTVVVLTPGVYNSAYFEHSLLARQMGVELVEGRD
LFCRDNQVYMRTTEGERQVDVIYRRIDDAFLDPLQFRADSVLGVAGLVNAARAGNVVL
SSAIGNGVGDDKLVYTYVPTMIEYYLHEKPLLANVETLRCWLDDEREEVLDRIRELVL
KPVEGSGGYGIVFGPEASQAELAAVSQKIRDDPRSWIAQPMMELSTVPTRIEGTLAPR
YVDLRPFAVNDGNEVWVLPGGLTRVALVEGSRVVNSSQGGGSKDTWVLAPRASAAARE
LGAAQIVRSLPQPLCDPTVDASGYEPHDQQPQQQQQQQQQAFH"
gene 2710075..2710335
/gene="rpsT"
/locus_tag="Rv2412"
CDS 2710075..2710335
/codon_start=1
/transl_table=11
/gene="rpsT"
/locus_tag="Rv2412"
/product="30S ribosomal protein S20 RpsT"
/note="Rv2412, (MT2485, MTCY253.08c), len: 86 aa. rpsT,
30s ribosomal protein s20, equivalent to
O33132|RS20_MYCLE|L0604|MLCL536.06 30S ribosomal protein
S20 from Mycobacterium leprae (86 aa), FASTA scores: opt:
456, E(): 4.6e-24, (87.20% identity in 86 aa overlap).
Also highly similar or similar to others e.g.
Q9RDM3|RPST|SCC123.01 30S ribosomal protein S20 from
Streptomyces coelicolor (88 aa), FASTA scores: opt:
363,E(): 7.1e-18, (70.95% identity in 86 aa overlap);
Q9KD79|RPST|BH1339 ribosomal protein S20 (BS20) from
Bacillus halodurans (91 aa), FASTA scores: opt: 252, E():
1.8e-10, (49.4% identity in 85 aa overlap);
P02378|RS20_ECOLI 30s ribosomal protein s20 from
Escherichia coli (86 aa), FASTA scores: opt: 210, E():
1e-07, (42.4% identity in 85 aa overlap); etc. Belongs to
the S20P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv2412"
/db_xref="EnsemblGenomes-Tr:CCP45203"
/db_xref="GOA:P9WH41"
/db_xref="InterPro:IPR002583"
/db_xref="InterPro:IPR036510"
/db_xref="UniProtKB/Swiss-Prot:P9WH41"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45203.1"
/translation="MANIKSQQKRNRTNERARLRNKAVKSSLRTAVRAFREAAHAGDK
AKAAELLASTNRKLDKAASKGVIHKNQAANKKSALAQALNKL"
gene complement(2710351..2711301)
/locus_tag="Rv2413c"
CDS complement(2710351..2711301)
/codon_start=1
/transl_table=11
/locus_tag="Rv2413c"
/product="Conserved hypothetical protein"
/note="Rv2413c, (MTCY253.07), len: 316 aa. Conserved
hypothetical protein, highly similar to
O33133|MLCL536.07c|ML0603|Q49756|G466975|B1937_F2_36
hypothetical 39.1 KDA protein from Mycobacterium leprae
(389 aa), FASTA scores: opt: 1683, E(): 1.8e-88, (83.9%
identity in 316 aa overlap). ML0603 is a putative
lipoprotein with an N-terminal signal sequence and
appropriately positioned prokaryotic lipoprotein lipid
attachment site that is not present in Rv2413c as this
seems to be 73 aa shorter. Also some similarity with
various proteins from other organisms e.g.
Q9RDM2|SCC123.02c putative DNA-binding protein from
Streptomyces coelicolor (336 aa), FASTA scores: opt:
792,E(): 6.1e-38, (42.4% identity in 316 aa overlap);
Q9HX31|HOLA|PA3989 DNA polymerase III, delta subunit from
Pseudomonas aeruginosa (345 aa), FASTA scores: opt:
173,E(): 0.0084, (25.4% identity in 307 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2413c"
/db_xref="EnsemblGenomes-Tr:CCP45204"
/db_xref="GOA:P71730"
/db_xref="InterPro:IPR008921"
/db_xref="InterPro:IPR010372"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P71730"
/protein_id="CCP45204.1"
/translation="MHLVLGDEELLVERAVADVLRSARQRAGTADVPVSRMRAGDVGA
YELAELLSPSLFAEERIVVLGAAAEAGKDAAAVIESAAADLPAGTVLVVVHSGGGRAK
SLANQLRSMGAQVHPCARITKVSERADFIRSEFASLRVKVDDETVTALLDAVGSDVRE
LASACSQLVADTGGAVDAAAVRRYHSGKAEVRGFDIADKAVAGDVAGAAEALRWAMMR
GEPLVVLADALAEAVHTIGRVGPQSGDPYRLAAQLGMPPWRVQKAQKQARRWSRDTVA
TAMRLVAELNANVKGAVADADYALESAVRQVAELVADRGR"
gene complement(2711332..2712876)
/locus_tag="Rv2414c"
CDS complement(2711332..2712876)
/codon_start=1
/transl_table=11
/locus_tag="Rv2414c"
/product="Conserved hypothetical protein"
/note="Rv2414c, (MTCY253.06), len: 514 aa. Conserved
hypothetical protein, showing some similarity with come
operon proteins 3 (COMEC or COME3) e.g. Q9RTB1|DR1854
putative competence protein COMEC/REC2 from Deinococcus
radiodurans (755 aa), FASTA scores: opt: 311, E():
8.2e-11,(27.3% identity in 538 aa overlap);
P73100|come|SLL1929 come protein from Synechocystis sp.
strain PCC 6803 (709 aa), FASTA scores: opt: 302, E():
2.6e-10, (26.3% identity in 323 aa overlap) (no similarity
on N-terminus); P39695|CME3_BACSU come operon protein 3
from Bacillus subtilis (776 aa), FASTA scores: opt: 273,
E(): 1.4e-08,(25.2% identity in 282 aa overlap) (no
similarity on N-terminus); etc."
/db_xref="EnsemblGenomes-Gn:Rv2414c"
/db_xref="EnsemblGenomes-Tr:CCP45205"
/db_xref="GOA:P71729"
/db_xref="InterPro:IPR004477"
/db_xref="UniProtKB/TrEMBL:P71729"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45205.1"
/translation="MGFGASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVAL
GGGALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPITVAFGT
SALVTVTPSESPVSLGRGRLMFRATVQRLRDDETSGRVVVFARALDFGELMVGQPVQF
RARISRPARHDLTVAVFNATGRPTVGRAGPVHRAAHIVRHRFAAAVREVLPADQATML
PALVLGDTSTVTALTSREFRAAGLTHLTAVSGANVTIVCAAALVSARLIGPRAAVVCA
AVALVAFVILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHLA
VDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVTAPLVAAISG
RVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVLIRFTGPEVWWVLRVAHW
ASGVPAATVPVAAGLPGVLLVGGATVFTVAQWRWRWFRAAMCKTMAVAVICLLAWSLS
GLVGPS"
gene complement(2712891..2713784)
/locus_tag="Rv2415c"
CDS complement(2712891..2713784)
/codon_start=1
/transl_table=11
/locus_tag="Rv2415c"
/product="Conserved hypothetical protein"
/note="Rv2415c, (MTCY253.05), len: 297 aa. Hypothetical
protein, with some similarity in C-terminal part to comE
operon proteins 1 e.g. Q9EU10|come|COME4|COME1|COME2|COME3
come protein (a competence protein with DNA-binding
activity) from Neisseria gonorrhoeae (99 aa), FASTA
scores: opt: 190, E(): 0.0032, (49.2% identity in 61 aa
overlap); Q9JYB8|NMB1657 from Neisseria meningitidis (205
aa) FASTA scores: opt: 191, E(): 0.0052, (49.2% identity
in 61 aa overlap); CME1_BACSU|P39694 come operon protein 1
from Bacillus subtilis (205 aa), FASTA scores, opt: 181,
E(): 0.017 (29.8% identity in 218 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2415c"
/db_xref="EnsemblGenomes-Tr:CCP45206"
/db_xref="GOA:P71728"
/db_xref="InterPro:IPR003583"
/db_xref="InterPro:IPR004509"
/db_xref="InterPro:IPR010994"
/db_xref="InterPro:IPR019554"
/db_xref="UniProtKB/TrEMBL:P71728"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45206.1"
/translation="MRTELPAERLQRRLGAVPDIDSHAASAHLDPEPHDPTDDGPDHD
EPRDDPNSLLPRWLPDTSRGQGWADRIRADPGRAGAVALAVIAALAVLVTVFTLIRDR
TEPVMSAKLPPVEPVSPTNPRSSASPGSPDRSGLPVVVSVVGLVHTPGLVTLAPGARI
ADALQAAGGAVDGADTVGLNMARQLGDGEQIVVGLAPPSGQPRVLGSSVGAGTPGPAG
TSGTATTGPKTAPKTAEVLDLNTATVEQLDALPGIGPVTAAAIVAWRQRNGRFTSVDQ
LADVDGIGPARLDKRRNLVRV"
gene complement(2714124..2715332)
/gene="eis"
/locus_tag="Rv2416c"
CDS complement(2714124..2715332)
/codon_start=1
/transl_table=11
/gene="eis"
/locus_tag="Rv2416c"
/product="Enhanced intracellular survival protein
Eis,GCN5-related N-acetyltransferase"
/note="Rv2416c, (MTCY253.04), len: 402 aa. Eis, enhanced
intracellular survival gene (see citations below).
Conserved hypothetical protein, contains GNAT
(Gcn5-related N-acetyltransferase) domain in N-terminal
part, similar to Q9F309|SCC80.10 hypothetical 44.7 KDA
protein from Streptomyces coelicolor (413 aa), FASTA
scores: opt: 382,E(): 1e-16, (31.45% identity in 407 aa
overlap); Q9K4F4|SCD66.23 conserved hypothetical protein
from Streptomyces coelicolor (418 aa), FASTA scores: opt:
238,E(): 1.3e-07, (36.5% identity in 364 aa overlap): and
Q54238|G1139577|ORF5 hypothetical protein from
Streptomyces griseus (416 aa), FASTA scores: opt: 237,
E(): 1.5e-07,(34.0 identity in 423 aa overlap). Start
changed since first submission (- 6 aa) (see Dahl et al.,
2001; Wei et al., 2000; Vetting et al. 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2416c"
/db_xref="EnsemblGenomes-Tr:CCP45207"
/db_xref="GOA:P9WFK7"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="InterPro:IPR022902"
/db_xref="InterPro:IPR025559"
/db_xref="InterPro:IPR036527"
/db_xref="InterPro:IPR041380"
/db_xref="PDB:3R1K"
/db_xref="PDB:3RYO"
/db_xref="PDB:3SXO"
/db_xref="PDB:3UY5"
/db_xref="PDB:4JD6"
/db_xref="PDB:5EBV"
/db_xref="PDB:5EC4"
/db_xref="PDB:5IV0"
/db_xref="PDB:5TVJ"
/db_xref="PDB:6B0U"
/db_xref="PDB:6B3T"
/db_xref="UniProtKB/Swiss-Prot:P9WFK7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45207.1"
/translation="MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDG
AVVVRDGAGPGSEVVGMALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCA
ELHRRIADSGYPVAALHASEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGG
SSVRLVRPTEHRGEFEAIYERWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALL
HPDGYALYRVDRTDLKLARVSELRAVTADAHCALWRALIGLDSMERISIITHPQDPLP
HLLTDTRLARTTWRQDGLWLRIMNVPAALEARGYAHEVGEFSTVLEVSDGGRFALKIG
DGRARCTPTDAAAEIEMDRDVLGSLYLGAHRASTLAAANRLRTKDSQLLRRLDAAFAS
DVPVQTAFEF"
gene complement(2715472..2716314)
/locus_tag="Rv2417c"
CDS complement(2715472..2716314)
/codon_start=1
/transl_table=11
/locus_tag="Rv2417c"
/product="Conserved protein"
/note="Rv2417c, (MTCY253.03), len: 280 aa. Conserved
protein, highly similar to Q9RDL7|SCC123.07c hypothetical
29.2 KDA protein from Streptomyces coelicolor (281
aa),FASTA scores: opt: 579, E(): 3.6e-27, (38.3% identity
in 274 aa overlap). Also some similarity with DEGV
proteins or hypothetical proteins from other organisms,
e.g. Q9RSY3|DR1986 from Deinococcus radiodurans (281 aa),
FASTA scores: opt: 393, E(): 3.4e-16, (31.0% identity in
280 aa overlap); P32436|DEGV_BACSU from Bacillus subtilis
(281 aa), FASTA scores: opt: 365, E(): 1.5e-14, (27.8%
identity in 284 aa overlap);
BAB41937|BAB46307|SA0704|SAV0749 Conserved hypothetical
protein from Staphylococcus aureus strain Mu50 and N315
(288 aa), FASTA scores: opt: 371, E(): 7e-15, (28.85%
identity in 281 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2417c"
/db_xref="EnsemblGenomes-Tr:CCP45208"
/db_xref="GOA:P9WP05"
/db_xref="InterPro:IPR003797"
/db_xref="UniProtKB/Swiss-Prot:P9WP05"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45208.1"
/translation="MTVVVVTDTSCRLPADLREQWSIRQVPLHILLDGLDLRDGVDEI
PDDIHKRHATTAGATPVELSAAYQRALADSGGDGVVAVHISSALSGTFRAAELTAAEL
GPAVRVIDSRSAAMGVGFAALAAGRAAAAGDELDTVARAAAAAVSRIHAFVAVARLDN
LRRSGRISGAKAWLGTALALKPLLSVDDGKLVLVQRVRTVSNATAVMIDRVCQLVGDR
PAALAVHHVADPAAANDVAAALAERLPACEPAMVTAMGPVLALHVGAGAVGVCVDVGA
SPPA"
repeat_region complement(2716315..2716391)
/note="77 bp Mycobacterial Interspersed Repetitive
Unit,Class I"
gene complement(2716395..2717138)
/locus_tag="Rv2418c"
CDS complement(2716395..2717138)
/codon_start=1
/transl_table=11
/locus_tag="Rv2418c"
/product="Unknown protein"
/note="Rv2418c, (MTCY253.02), len: 247 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv2418c"
/db_xref="EnsemblGenomes-Tr:CCP45209"
/db_xref="GOA:P71725"
/db_xref="UniProtKB/Swiss-Prot:P71725"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45209.1"
/translation="MSSRRGRRPALLVFADSLAYYGPTGGLPADDPRIWPNIVASQLD
WDLELIGRIGWTCRDVWWAATQDPRAWAALPRAGAVIFATGGMDSLPSVLPTALRELI
RYVRPSWLRRWVRDGYAWVQPRLSPVARAALPPHLTAEYLEKTRGAIDFNRPGIPIIA
SLPSVHIAETYGKAHHGRAGTVAAITEWAQHHDIPLVDLKAAVAEQILSGYGNRDGIH
WNFEAHQAVAELMLKALAEAGVPNEKSRG"
gene complement(2717128..2717799)
/gene="gpgP"
/locus_tag="Rv2419c"
CDS complement(2717128..2717799)
/codon_start=1
/transl_table=11
/gene="gpgP"
/locus_tag="Rv2419c"
/product="Glucosyl-3-phosphoglycerate phosphatase GpgP"
/note="Rv2419c, (MTCY428.28-MTCY253.01), len: 223 aa.
gpgP,glucosyl-3-phosphoglycerate phosphatase (See Mendes
et al.,2011). Contains PS00175 Phosphoglycerate mutase
family phosphohistidine signature. Belongs to the
phosphoglycerate mutase family. Enzyme activity inhibited
by Co2+ and Cu2+ (See Mendes et al., 2011)."
/db_xref="EnsemblGenomes-Gn:Rv2419c"
/db_xref="EnsemblGenomes-Tr:CCP45210"
/db_xref="GOA:P9WIC7"
/db_xref="InterPro:IPR001345"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="PDB:4PZ9"
/db_xref="PDB:4PZA"
/db_xref="PDB:4QIH"
/db_xref="UniProtKB/Swiss-Prot:P9WIC7"
/inference="protein motif:PROSITE:PS00175"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45210.1"
/translation="MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEV
LGKRQPLLIVSSDLRRAYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDADA
PGARLAWREDATWAPHGGESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHG
GLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQV
SSDVL"
gene complement(2717796..2718176)
/locus_tag="Rv2420c"
CDS complement(2717796..2718176)
/codon_start=1
/transl_table=11
/locus_tag="Rv2420c"
/product="Conserved hypothetical protein"
/note="Rv2420c, (MTCY428.27), len: 126 aa. Conserved
hypothetical protein, equivalent to Q9CBZ9|ML1453
hypothetical protein from Mycobacterium leprae (129
aa),FASTA scores: opt: 681, E(): 1.6e-38, (87.0% identity
in 123 aa overlap). Also highly similar to
Q9RDK9|SCC123.15c hypothetical protein from Streptomyces
coelicolor (148 aa),FASTA scores: opt: 447, E(): 5.8e-23,
(52.7% identity in 129 aa overlap); and similar to others
e.g. P54457|YQEL_BACSU hypothetical protein from Bacillus
subtilis (118 aa), FASTA scores: opt: 318, E():
1.8e-14,(37.3% identity in 110 aa overlap); Q9KD89|BH1328
hypothetical protein from Bacillus halodurans (117
aa),FASTA scores: opt: 296, E(): 5.1e-13, (37.6% identity
in 109 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2420c"
/db_xref="EnsemblGenomes-Tr:CCP45211"
/db_xref="GOA:O86327"
/db_xref="InterPro:IPR004394"
/db_xref="PDB:4WCW"
/db_xref="UniProtKB/TrEMBL:O86327"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45211.1"
/translation="MTANREAIDMARVAAGAAAAKLADDVVVIDVSGQLVITDCFVIA
SGSNERQVNAIVDEVEEKMRQAGYRPARREGAREGRWTLLDYRDIVVHIQHQDDRNFY
ALDRLWGDCPVVPVDLSANSAGAQ"
gene complement(2718173..2718808)
/gene="nadD"
/locus_tag="Rv2421c"
CDS complement(2718173..2718808)
/codon_start=1
/transl_table=11
/gene="nadD"
/locus_tag="Rv2421c"
/product="Probable nicotinate-nucleotide
adenylyltransferase NadD (deamido-NAD(+)
pyrophosphorylase) (deamido-NAD(+) diphosphorylase)
(nicotinate mononucleotide adenylyltransferase) (NAMN
adenylyltransferase)"
/note="Rv2421c, (MT2494, MTCY428.26), len: 211 aa.
Probable nadD, nicotinate-nucleotide adenylyltransferase
,equivalent to Q9CBZ8|NADD_MYCLE|ML1454 probable
nicotinate-nucleotide adenylyltransferase from
Mycobacterium leprae (214 aa), FASTA scores: opt:
1125,E(): 2.7e-66, (80.2% identity in 212 aa overlap).
Also highly similar to Q9RDK7|NADD_STRCO probable
nicotinate-nucleotide adenylyltransferase from
Streptomyces coelicolor (188 aa), FASTA scores: opt: 855,
E(): 9.8e-49,(66.5% identity in 194 aa overlap); and
similar to others e.g. P54455|NADD_BACSU from Bacillus
subtilis (189 aa),FASTA scores: opt: 351, E(): 7e-16,
(36.1% identity in 191 aa overlap); etc. Belongs to the
NadD family."
/db_xref="EnsemblGenomes-Gn:Rv2421c"
/db_xref="EnsemblGenomes-Tr:CCP45212"
/db_xref="GOA:P9WJJ5"
/db_xref="InterPro:IPR004821"
/db_xref="InterPro:IPR005248"
/db_xref="InterPro:IPR014729"
/db_xref="PDB:4RPI"
/db_xref="PDB:4S1O"
/db_xref="PDB:4X0E"
/db_xref="PDB:4YBR"
/db_xref="PDB:5DAS"
/db_xref="PDB:6BUV"
/db_xref="UniProtKB/Swiss-Prot:P9WJJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45212.1"
/translation="MGGTFDPIHYGHLVAASEVADLFDLDEVVFVPSGQPWQKGRQVS
AAEHRYLMTVIATASNPRFSVSRVDIDRGGPTYTKDTLADLHALHPDSELYFTTGADA
LASIMSWQGWEELFELARFVGVSRPGYELRNEHITSLLGQLAKDALTLVEIPALAISS
TDCRQRAEQSRPLWYLMPDGVVQYVSKCRLYCGACDAGARSTTSLAAGNGL"
gene 2719083..2719355
/locus_tag="Rv2422"
CDS 2719083..2719355
/codon_start=1
/transl_table=11
/locus_tag="Rv2422"
/product="Hypothetical protein"
/note="Rv2422, (MTCY428.25c), len: 90 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2422"
/db_xref="EnsemblGenomes-Tr:CCP45213"
/db_xref="UniProtKB/TrEMBL:P71926"
/protein_id="CCP45213.1"
/translation="MPASVSTVLVDTSVAVAPVVADHDHHEDTFQALRGRTLGLAGHA
AFERRTLATVAKLLAHTFPATRFLGAGAAMSLLPELAPAEIAGGAV"
gene 2719597..2720643
/locus_tag="Rv2423"
CDS 2719597..2720643
/codon_start=1
/transl_table=11
/locus_tag="Rv2423"
/product="Hypothetical protein"
/note="Rv2423, (MTCY428.24c), len: 348 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2423"
/db_xref="EnsemblGenomes-Tr:CCP45214"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:P71925"
/protein_id="CCP45214.1"
/translation="MDNLPIESAESTRLAKAAMTRRFYTRSVVKGEITLPAVPSMIDE
YVTMCAGLFAGVGRKFSDEELAHLRAVLQGQLAEAYAASQRSTIVISYNAPMGPTLHY
QVRAQWRTVAQEYENWIATREPPLFGTEPDARVWALANEAADPTTHRVLEIGAGTGRN
ALALARRGHPVDVVEMTPKFADIIRSDAERDSLDVRVIMRDVFSTMDDLRQDYQLMVL
SEVVPDFRTTQQLRNLFELAAQCLAPGARLVFNAFLANGDYAPDQAAREFGQQMYTGM
CTRAEMSAAAAGLPLELVADDSVYDYEKTHLPPGAWPPTSWYADWIRGLDVFTTNVES
CPIEMRWLVFQRRR"
repeat_region 2720644..2720656
/note="13 bp inverted repeat, GCAGTCG(C)AAAAG, at the left
end of IS1558"
gene complement(2720776..2721777)
/locus_tag="Rv2424c"
CDS complement(2720776..2721777)
/codon_start=1
/transl_table=11
/locus_tag="Rv2424c"
/product="Probable transposase"
/note="Rv2424c, (MTCY428.23), len: 333 aa. Probable
transposase for IS1558, similar to is element proteins
e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium
tuberculosis (221 aa), FASTA scores: opt: 1491, E():
6.2e-87, (98.6% identity in 221 aa overlap);
P19780|YIS1_STRCO hypothetical insertion element IS110
from Streptomyces coelicolor (45 aa), FASTA scores: opt:
203, E(): 1.7e-05; (27.3% identity in 238 aa overlap);
etc. Contains PS01159 WW/rsp5/WWP domain signature."
/db_xref="EnsemblGenomes-Gn:Rv2424c"
/db_xref="EnsemblGenomes-Tr:CCP45215"
/db_xref="GOA:P71924"
/db_xref="InterPro:IPR003346"
/db_xref="UniProtKB/TrEMBL:P71924"
/inference="protein motif:PROSITE:PS01159"
/protein_id="CCP45215.1"
/translation="MQCRAREERPGRKTDLLDAEWLVHLLECGLLRGWLIPPADIKAA
RDVIRYRRKLVEHRTSKLQRLGNVLQDAGIKADSVASSVTPKSVRAMVEALIDGERRP
AVLADLARGSMRSKIPDLQRALEGRFDDHHALMCRLHLAHLDQLDAMIGALDEQIEQL
MHPFCARRELIASIPGIGVGASATVISEIGADPAAWFPSAEHLASWVRLCPGNHESAG
KRHHGARRTGNQHLQPVLVECAWAAVRTDGYLREYYRRQVRKFGGFRSPAANKKAITT
VAHKLIVIIWHVLATGRPHQDLGADYFTTRMDPDKERRRLVAKLEAQGLGVTLEPAA"
mobile_element complement(2720779..2721777)
/mobile_element_type="insertion sequence:IS1558-2"
/locus_tag="Rv2424c"
/note="IS1558-2, len: 999 nt. Insertion sequence IS1558."
repeat_region complement(2721844..2721856)
/note="13 bp inverted repeat, GCAGTCG(T)AAAAG, at the
right end of IS1558"
gene complement(2721866..2723308)
/locus_tag="Rv2425c"
CDS complement(2721866..2723308)
/codon_start=1
/transl_table=11
/locus_tag="Rv2425c"
/product="Conserved hypothetical protein"
/note="Rv2425c, (MTCY428.22), len: 480 aa. Hypothetical
protein; C-terminal half shares similarity to other
unknown conserved proteins e.g. Q53065 hypothetical 24.3
KDA protein from Rhodococcus erythropolis (219 aa), FASTA
scores: opt: 398, E(): 9.9e-17, (34.15% identity in 202 aa
overlap); C-terminus of O27843|MTH1815 conserved protein
from Methanothermobacter thermautotrophicus (346 aa),
FASTA scores: opt: 341, E(): 3.7e-13, (31.35% identity in
233 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2425c"
/db_xref="EnsemblGenomes-Tr:CCP45216"
/db_xref="InterPro:IPR008912"
/db_xref="InterPro:IPR011195"
/db_xref="InterPro:IPR036465"
/db_xref="UniProtKB/TrEMBL:P71923"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45216.1"
/translation="MAARRIRAARPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAG
RVMATLGLGDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVITTEDESAG
SGGLPPDDVEAMRQLLLDLLANNQDLAGKDERLVEMIARIVEAYGKYSSSRGPSFSSY
QALKAMALDELEGKLLAGLLAPYGDEPTATQEQIAKALAAQKIAQLRRMVDAETKRRT
AEQLGREHVQMYGIPQLSENVEFLRASGEQLRQMRRVVAPLARTLATRLAARRRRARA
GSIDLRKTLRKSMSTGGVPIDLVLHKPRPARPELVVLCDVSGSVAGFSHFTLLLVHAL
RQQFSRVRVFAFIDSTDEVTHMFGPESDLAIAIQRITREAGVYARDGHSDYGNAFVSF
MQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPKHLWGSGDS
AVPRYQEVITMHECRSAKQLATVIDQLLPV"
gene complement(2723308..2724183)
/locus_tag="Rv2426c"
CDS complement(2723308..2724183)
/codon_start=1
/transl_table=11
/locus_tag="Rv2426c"
/product="Conserved hypothetical protein"
/note="Rv2426c, (MTCY428.21), len: 291 aa. Conserved
hypothetical protein, highly similar to others e.g.
Q51326|ORF4 from Pseudomonas carboxydovorans (295
aa),FASTA scores: opt: 853, E(): 3.7e-43, (48.75% identity
in 277 aa overlap); BAB47746|MLR0088 from Rhizobium loti
(309 aa), FASTA scores: opt :809, E(): 1.5e-40, (46.5%
identity in 291 aa overlap); Q9Y9R8|APE2220 from Aeropyrum
pernix (297 aa), FASTA scores: opt: 763, E(): 7.4e-38,
(47.1% identity in 261 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2426c"
/db_xref="EnsemblGenomes-Tr:CCP45217"
/db_xref="GOA:P71922"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011704"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P71922"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45217.1"
/translation="MTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGK
PLLVEGPAGVGKTELARAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGS
GDWEATKTDVFSEEFLLQRPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAV
TVPELGTLTATRAPFVLLTSNATRELSEALKRRCLYLHIDFPTPELERRILLSRVPEL
PEHFAEELVRIIGVLRGMQLKKVPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLK
HQSDQQRATGELRLN"
gene complement(2724230..2725477)
/gene="proA"
/locus_tag="Rv2427c"
CDS complement(2724230..2725477)
/codon_start=1
/transl_table=11
/gene="proA"
/locus_tag="Rv2427c"
/product="Probable gamma-glutamyl phosphate reductase
protein ProA (GPR) (glutamate-5-semialdehyde
dehydrogenase) (glutamyl-gamma-semialdehyde
dehydrogenase)"
/note="Rv2427c, (MTCY428.20), len: 415 aa. Probable
proA,gamma-glutamyl phosphate reductase protein,
equivalent to Q9CBZ7|ML1458|PROA [gamma]-glutamyl
phosphate reductase from Mycobacterium leprae (409 aa),
FASTA scores: opt: 2120, E(): 7.4e-118, (81.9% identity in
409 aa overlap). Also highly similar or similar to other
gamma-glutamyl phosphate reductases proteins (GPR) e.g.
Q9RDK1|PROA from Streptomyces coelicolor (428 aa), FASTA
scores: opt: 1073,E(): 4.6e-56, (60.4% identity in 429 aa
overlap); P45638|PROA_CORGL from Corynebacterium
glutamicum (432 aa),FASTA scores: opt: 993, E(): 2.4e-51,
(58.5% identity in 417 aa overlap); P96489|PROA_STRTR
gamma-glutamyl phosphate reductase from Streptococcus
thermophilus (416 aa), FASTA scores: opt: 863, E():
1.1e-43, (49.15% identity in 413 aa overlap); etc. Belongs
to the gamma-glutamyl phosphate reductase family."
/db_xref="EnsemblGenomes-Gn:Rv2427c"
/db_xref="EnsemblGenomes-Tr:CCP45218"
/db_xref="GOA:P9WHV1"
/db_xref="InterPro:IPR000965"
/db_xref="InterPro:IPR012134"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR020593"
/db_xref="UniProtKB/Swiss-Prot:P9WHV1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45218.1"
/translation="MTVPAPSQLDLRQEVHDAARRARVAARRLASLPTTVKDRALHAA
ADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSLNPQRVDGIAAGLRQVAGLRDP
VGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLTLKSGNAALLRGSSS
AAKSNEALVAVLRTALVGLELPADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGL
IEAVVRDAQVPTIETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDA
AIAETALPRLLAALQHAGVTVHLDPDEADLRREYLSLDIAVAVVDGVDAAIAHINEYG
TGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARG
PMGLPELTSTKWIAWGAGHTRPA"
gene complement(2725571..2726087)
/pseudo
/gene="oxyR'"
/locus_tag="Rv2427A"
CDS complement(2725571..2726087)
/codon_start=1
/transl_table=11
/gene="oxyR'"
/locus_tag="Rv2427A"
/product="Transcriptional regulator OxyR', pseudogene"
/note="Rv2427A, Pseudogene oxyR', inactivated by multiple
mutations; identical to sequence in u16243 (see Deretic et
al., 1995)."
/pseudogene="unknown"
gene 2726193..2726780
/gene="ahpC"
/locus_tag="Rv2428"
CDS 2726193..2726780
/codon_start=1
/transl_table=11
/gene="ahpC"
/locus_tag="Rv2428"
/product="Alkyl hydroperoxide reductase C protein AhpC
(alkyl hydroperoxidase C)"
/note="Rv2428, (MTCY428.18c), len: 195 aa. AhpC, alkyl
hydroperoxide reductase C (see citations below),
equivalent to other alkyl hydroperoxide reductases C
mycobacterial proteins e.g. Q9CBF5|AHPC|ML2042 alkyl
hydroperoxide reductase from Mycobacterium leprae (195 aa)
FASTA scores: opt: 1183, E(): 2.6e-72, (88.20% identity in
195 aa overlap); O87323|AHPC from Mycobacterium marinum
(195 aa),FASTA scores: opt: 1215, E(): 1.9e-74, (90.8%
identity in 195 aa overlap); Q57413|AHPC|AVI-3 from
Mycobacterium avium (195 aa), FASTA scores: opt: 1201,
E(): 1.6e-73, (90.25% identity in 195 aa overlap). Also
highly similar to others from other organisms e.g.
Q9FBP5|AHPC alkyl hydroperoxide reductase from
Streptomyces coelicolor (184 aa), FASTA scores: opt: 768,
E(): 1.7e-44, (62.45% identity in 189 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2428"
/db_xref="EnsemblGenomes-Tr:CCP45220"
/db_xref="GOA:P9WQB7"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR024706"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:2BMX"
/db_xref="UniProtKB/Swiss-Prot:P9WQB7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45220.1"
/translation="MPLLTIGDQFPAYQLTALIGGDLSKVDAKQPGDYFTTITSDEHP
GKWRVVFFWPKDFTFVCPTEIAAFSKLNDEFEDRDAQILGVSIDSEFAHFQWRAQHND
LKTLPFPMLSDIKRELSQAAGVLNADGVADRVTFIVDPNNEIQFVSATAGSVGRNVDE
VLRVLDALQSDELCACNWRKGDPTLDAGELLKASA"
gene 2726806..2727339
/gene="ahpD"
/locus_tag="Rv2429"
CDS 2726806..2727339
/codon_start=1
/transl_table=11
/gene="ahpD"
/locus_tag="Rv2429"
/product="Alkyl hydroperoxide reductase D protein AhpD
(alkyl hydroperoxidase D)"
/note="Rv2429, (MTCY428.17c), len: 177 aa. AhpD, alkyl
hydroperoxide reductase, similar to other alkyl
hydroperoxide reductases D proteins e.g. Q9RN73|AHPD from
Streptomyces coelicolor (178 aa), FASTA scores: opt:
611,E(): 1.4e-33, (57.4% identity in 169 aa overlap);
Q50441|AHPD_MYCSM AHPD protein (fragment) from
Mycobacterium smegmatis (52 aa), FASTA score: opt:196."
/db_xref="EnsemblGenomes-Gn:Rv2429"
/db_xref="EnsemblGenomes-Tr:CCP45221"
/db_xref="GOA:P9WQB5"
/db_xref="InterPro:IPR003779"
/db_xref="InterPro:IPR004674"
/db_xref="InterPro:IPR004675"
/db_xref="InterPro:IPR029032"
/db_xref="PDB:1GU9"
/db_xref="PDB:1KNC"
/db_xref="PDB:1LW1"
/db_xref="PDB:1ME5"
/db_xref="UniProtKB/Swiss-Prot:P9WQB5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45221.1"
/translation="MSIEKLKAALPEYAKDIKLNLSSITRSSVLDQEQLWGTLLASAA
ATRNPQVLADIGAEATDHLSAAARHAALGAAAIMGMNNVFYRGRGFLEGRYDDLRPGL
RMNIIANPGIPKANFELWSFAVSAINGCSHCLVAHEHTLRTVGVDREAIFEALKAAAI
VSGVAQALATIEALSPS"
gene complement(2727336..2727920)
/gene="PPE41"
/locus_tag="Rv2430c"
CDS complement(2727336..2727920)
/codon_start=1
/transl_table=11
/gene="PPE41"
/locus_tag="Rv2430c"
/product="PPE family protein PPE41"
/note="Rv2430c, (MTCY428.16), len: 194 aa. PPE41, Member
of the Mycobacterium tuberculosis PPE family similar to
others e.g. AAK46014|Rv1745|MT1745 from Mycobacterium
tuberculosis (385 aa) FASTA scores: opt: 389, E():
1.2e-17, (35.95% identity in 192 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2430c"
/db_xref="EnsemblGenomes-Tr:CCP45222"
/db_xref="GOA:Q79FE1"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="PDB:2G38"
/db_xref="PDB:4KXR"
/db_xref="PDB:4W4K"
/db_xref="PDB:4W4L"
/db_xref="UniProtKB/Swiss-Prot:Q79FE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45222.1"
/translation="MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRS
FNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHD
MVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDA
LSKLTPWKAPPPIAHSTVLVAPVSPSTASSRTDT"
gene complement(2727967..2728266)
/gene="PE25"
/locus_tag="Rv2431c"
CDS complement(2727967..2728266)
/codon_start=1
/transl_table=11
/gene="PE25"
/locus_tag="Rv2431c"
/product="PE family protein PE25"
/note="Rv2431c, (MTCY428.15), len: 99 aa. PE25, Member of
the Mycobacterium tuberculosis PE family (see Brennan &
Delogu 2002), similar to others e.g. AAK47158|MT2839 from
Mycobacterium tuberculosis (275 aa) FASTA scores: opt:
194,E(): 2.5e-06, (40.0% identity in 95 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2431c"
/db_xref="EnsemblGenomes-Tr:CCP45223"
/db_xref="GOA:I6X486"
/db_xref="InterPro:IPR000084"
/db_xref="PDB:2G38"
/db_xref="PDB:4KXR"
/db_xref="PDB:4W4K"
/db_xref="PDB:4W4L"
/db_xref="UniProtKB/Swiss-Prot:I6X486"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45223.1"
/translation="MSFVITNPEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAA
DLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTGADKYATAEADNIKTFS"
gene complement(2728437..2728847)
/locus_tag="Rv2432c"
CDS complement(2728437..2728847)
/codon_start=1
/transl_table=11
/locus_tag="Rv2432c"
/product="Hypothetical protein"
/note="Rv2432c, (MTCY428.14), len: 136 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2432c"
/db_xref="EnsemblGenomes-Tr:CCP45224"
/db_xref="UniProtKB/TrEMBL:P71917"
/protein_id="CCP45224.1"
/translation="MTVRAEHCRGAGGCDECPSVMPEHPTALFHDVAAIALAQPGAEP
GAMMGFPCRPALLPHLSRAVMRCVRTRSASTSLGVSVIAGQLPAAGSRHRLGAPCRHV
RWWLASDGHWGMVSYIPTALNVSMGGIVGWRCVP"
gene complement(2728844..2729134)
/locus_tag="Rv2433c"
CDS complement(2728844..2729134)
/codon_start=1
/transl_table=11
/locus_tag="Rv2433c"
/product="Hypothetical protein"
/note="Rv2433c, (MTCY428.13), len: 96 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2433c"
/db_xref="EnsemblGenomes-Tr:CCP45225"
/db_xref="GOA:P71916"
/db_xref="UniProtKB/TrEMBL:P71916"
/protein_id="CCP45225.1"
/translation="MGLRDADERWDTVGQAIGLFLRGHTLRTAAPTALIVGTVLCAVN
QGATLAEGAATIGTWVRMVINYLVPFLVASVGYLGARRGVRRASGRSDPSAQ"
gene complement(2729115..2730560)
/locus_tag="Rv2434c"
CDS complement(2729115..2730560)
/codon_start=1
/transl_table=11
/locus_tag="Rv2434c"
/product="Probable conserved transmembrane protein"
/note="Rv2434c, (MTCY428.12), len: 481 aa. Probable
conserved transmembrane protein, with some similarity to
BAB48444|MLR0973 probable integral membrane protein from
Rhizobium loti (410 aa), FASTA scores: opt: 298, E():
4.1e-11, (27.25% identity in 389 aa overlap); and also
similarity with other hypothetical proteins and/or
putative integral membrane proteins."
/db_xref="EnsemblGenomes-Gn:Rv2434c"
/db_xref="EnsemblGenomes-Tr:CCP45226"
/db_xref="GOA:P71915"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR006685"
/db_xref="InterPro:IPR010920"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016846"
/db_xref="InterPro:IPR018490"
/db_xref="UniProtKB/TrEMBL:P71915"
/protein_id="CCP45226.1"
/translation="MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQA
SLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLNATLFQGAP
QQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNS
VGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSGLQIMPNSMLATT
AFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAE
YRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGP
ELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVA
IATLKKGTFLGLTALTRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVI
DERQRKAQQAIRRDLHQSPAAAGEHRGPARR"
gene complement(2730557..2732749)
/locus_tag="Rv2435c"
CDS complement(2730557..2732749)
/codon_start=1
/transl_table=11
/locus_tag="Rv2435c"
/product="Probable cyclase (adenylyl-or
guanylyl-)(adenylate-or guanylate-)"
/note="Rv2435c, (MTCY428.11), len: 730 aa. Probable
cyclase (adenylyl- or guanylyl-cyclase; EC 4.6.1.1 or
4.6.1.2 respectively); C-terminal domain (aa 500-730)
similar to domain at C-terminus of a series of
adenylate/guanylate cyclases e.g. O30820|CYA
AAK45931|MT1661 from Mycobacterium tuberculosis (443 aa)
FASTA scores: opt: 446, E(): 1.3e-19,(30.55% identity in
301 aa overlap); BAB50179|MLL3242 cyclase (adenylyl or
guanylyl) from Rhizobium loti (356 aa), FASTA scores: opt:
372, E(): 3.4e-15, (28.75% identity in 219 aa overlap);
etc. Belongs to adenylyl cyclase class-4/guanylyl cyclase
family."
/db_xref="EnsemblGenomes-Gn:Rv2435c"
/db_xref="EnsemblGenomes-Tr:CCP45227"
/db_xref="GOA:P71914"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/TrEMBL:P71914"
/protein_id="CCP45227.1"
/translation="MTSGEALDSVAESESTPAKKRHKNVLRRRPRFRASIQSKLMVLL
LLTSIVSVAAIAAIVYQSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLVIYER
GLTVVDAVVRFTAGFDQLADATISPAQQQAIVNYYNNEFITPVERTTGDKLDITALLP
TSPAQRYLQAYYTAPFTSDQDAMRLDDAGDGSAWSAANAQFNSYFREIVTRFDYDDAV
LLDTRGNIVYTLSKDPDLGTNILTGPYRESNLRDAYLKALGANAVDFTWITDFKPYQP
QLGVPTAWLVAPVEAGGKTQGVLALPLPIDKINKIMTADRQWQAAGMGSGTETYLAGP
DSLMRSDSRLFLQDPEEYRKQVVAAGTSLDVVNRAIQFGGTTLLQPVATEGLRAAQRG
QTGTVTSTDYTGSRELEAYAPLNVPDSDLHWSILATRNDSEAFAAVASFSRALVLVTV
GIIVVICVASMLIAHAMVRPIRRLEVGTQKISAGDYEVNIPVKSRDEIGDLTAAFNEM
SRNLQTKEELLNEQRKENDRLLLSMMPEPVVERYRLGEQTIAQEHQDVTVLFADILGV
DEISSGLSGNELVKIVDELVRQFDSAAEHLGVERIRTLHNGYLAGCGVTTPRLDNIPR
TVDFALEMRRIVDRFNCQTGNDLHLRVGINTGDVISGLVGRSSVVYDMWGAAVSLAYQ
MHSGSPQPGIYVTSQVYEAMRDVWQFTAAGTISVGGLEEPIYRLSERS"
gene 2733230..2734144
/gene="rbsK"
/locus_tag="Rv2436"
CDS 2733230..2734144
/codon_start=1
/transl_table=11
/gene="rbsK"
/locus_tag="Rv2436"
/product="Ribokinase RbsK"
/note="Rv2436, (MTCY428.10c), len: 304 aa. Probable
rbsK,ribokinase, similar to others e.g. Q9RZ99|DRA0055
from Deinococcus radiodurans (300 aa) FASTA scores: opt:
485,E(): 9.1e-21, (44.55% identity in 301 aa overlap);
P36945|P96733|RBSK_BACSU from Bacillus subtilis (293
aa),FASTA scores: opt: 398, E(): 8.5e-16, (36.35% identity
in 297 aa overlap); P05054|RBSK_ECOLI|B3752|Z5253|ECS4694
from Escherichia coli strain K12 (309 aa), FASTA scores:
opt: 387, E(): 3.8e-15, (34.7% identity in 314 aa
overlap); etc. Contains PS00583 pfkB family of
carbohydrate kinases signature 1. Belongs to the PFKB
family of carbohydrate kinases."
/db_xref="EnsemblGenomes-Gn:Rv2436"
/db_xref="EnsemblGenomes-Tr:CCP45228"
/db_xref="GOA:P71913"
/db_xref="InterPro:IPR002139"
/db_xref="InterPro:IPR011611"
/db_xref="InterPro:IPR011877"
/db_xref="InterPro:IPR029056"
/db_xref="PDB:3GO6"
/db_xref="PDB:3GO7"
/db_xref="UniProtKB/TrEMBL:P71913"
/inference="protein motif:PROSITE:PS00583"
/protein_id="CCP45228.1"
/translation="MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAAS
LTRTPGGKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVPGP
SGTAIIVVDASAENTVLVAPGANAHLTPVPSAVANCDVLLTQLEIPVATALAAARAAQ
SADAVVMVNASPAGQDRSSLQDLAAIADVVIANEHEANDWPSPPTHFVITLGVRGARY
VGADGVFEVPAPTVTPVDTAGAGDVFAGVLAANWPRNPGSPAERLRALRRACAAGALA
TLVSGVGDCAPAAAAIDAALRANRHNGS"
gene 2734376..2734795
/locus_tag="Rv2437"
CDS 2734376..2734795
/codon_start=1
/transl_table=11
/locus_tag="Rv2437"
/product="Conserved transmembrane protein"
/note="Rv2437, (MTCY428.09c), len: 139 aa. Conserved
transmembrane protein, with some similarity to conserved
hypothetical proteins e.g. O06539|RV1139C|MTCI65.06c from
Mycobacterium tuberculosis (166 aa); AAK45430|MT1172 from
Mycobacterium tuberculosis (124 aa), FASTA scores: opt:
166, E(): 0.00013, (35.7% identity in 112 aa overlap);
BAB48937|Mlr1600 from Rhizobium loti (222 aa), FASTA
scores: opt: 163 ,E(): 0.00033, (28.1% identity in 121 aa
overlap); etc. Contains membrane spanning regions."
/db_xref="EnsemblGenomes-Gn:Rv2437"
/db_xref="EnsemblGenomes-Tr:CCP45229"
/db_xref="GOA:P71912"
/db_xref="InterPro:IPR007318"
/db_xref="UniProtKB/TrEMBL:P71912"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45229.1"
/translation="MLQRTNVVQPLNTLRMVWIQVAGIIPATAGIAATVYAQLAMGDS
WRIGVDEQENTTLVRTGPFKWVRHPIYTAMMAFGLGLLLVTPNLVALAGFILLVATLE
VHVRRVEEPYLLRTHSAVYRGYTASVGRFVPGVGLIR"
gene complement(2734792..2736831)
/gene="nadE"
/locus_tag="Rv2438c"
CDS complement(2734792..2736831)
/codon_start=1
/transl_table=11
/gene="nadE"
/locus_tag="Rv2438c"
/product="Glutamine-dependent NAD(+) synthetase NadE
(NAD(+) synthase [glutamine-hydrolysing])"
/note="Rv2438c, (MT2513, MTCY428.08), len: 679 aa.
NadE,glutamine-dependent NAD(+) synthetase (see citation
below),equivalent to Q9CBZ6|NADE_MYCLE|ML1463
Glutamine-dependent NAD(+) synthetase from Mycobacterium
leprae (680 aa), FASTA scores: opt: 3877, E(): 0. Also
similar to others e.g. O83759|NADE_TREPA|TP0780 from
Treponema pallidum (679 aa),FASTA scores: opt: 543, E():
1.1e-25; O74940|NADE_SCHPO|SPCC553.02 from
Schizosaccharomyces pombe (Fission yeast) (700 aa), FASTA
scores: opt: 354, E(): 4.7e-14 ; P38795|NADE_YEAST|YHR074W
from Saccharomyces cerevisiae (Baker's yeast) (714 aa),
FASTA scores: opt: 339, E(): 4e-13; etc. Contains PS00591
Glycosyl hydrolases family 10 active site. Belongs to the
NAD synthetase family in the C-terminal section.
N-terminus shorter since first submission."
/db_xref="EnsemblGenomes-Gn:Rv2438c"
/db_xref="EnsemblGenomes-Tr:CCP45230"
/db_xref="GOA:P9WJJ3"
/db_xref="InterPro:IPR003010"
/db_xref="InterPro:IPR003694"
/db_xref="InterPro:IPR014445"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR022310"
/db_xref="InterPro:IPR036526"
/db_xref="InterPro:IPR041856"
/db_xref="PDB:3DLA"
/db_xref="PDB:3SDB"
/db_xref="PDB:3SEQ"
/db_xref="PDB:3SEZ"
/db_xref="PDB:3SYT"
/db_xref="PDB:3SZG"
/db_xref="UniProtKB/Swiss-Prot:P9WJJ3"
/inference="protein motif:PROSITE:PS00591"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45230.1"
/translation="MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDG
AALAVFPELTLSGYSIEDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRHRHR
IYNTAVVIHRGAVLGVVPKSYLPTYREFYERRQMAPGDGERGTIRIGGADVAFGTDLL
FAASDLPGFVLHVEICEDMFVPMPPSAEAALAGATVLANLSGSPITIGRAEDRRLLAR
SASARCLAAYVYAAAGEGESTTDLAWDGQTMIWENGALLAESERFPKGVRRSVADVDT
ELLRSERLRMGTFDDNRRHHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQ
RLQQDCYEAYNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRS
DILAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPYSVGEKVY
DVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTYGVGDQMSHYNVNAGV
PKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEITPELIPTGEEELQSSEAKVGPFAL
QDFSLFQVLRYGFRPSKIAFLAWHAWNDAERGNWPPGFPKSERPSYSLAEIRHWLQIF
VQRFYSFSQFKRSALPNGPKVSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG"
gene 2736709..2736987
/locus_tag="Rv2438A"
CDS 2736709..2736987
/codon_start=1
/transl_table=11
/locus_tag="Rv2438A"
/product="Conserved hypothetical protein"
/note="Rv2438A, len: 92 aa. Conserved hypothetical
protein,showing few similarity with various enzymes e.g.
part of O83441|VAA1_TREPA|ATPA1|TP0426 V-type ATP synthase
alpha chain 1 from Treponema pallidum (589 aa), FASTA
scores: opt: 110, E(): 1.5, (40.3% identity in 72 aa
overlap); N-terminus of O95178|NIGM_HUMAN NADH-ubiquinone
oxidoreductase AGGG subunit precursor from Homo sapiens
(105 aa), FASTA scores: opt: 109, E(): 1.5, (35.5%
identity in 62 aa overlap); N-terminus of Q9HJ76|TA1096
probable glycerol kinase from Thermoplasma acidophilum
(488 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv2438A"
/db_xref="EnsemblGenomes-Tr:CCP45231"
/db_xref="UniProtKB/TrEMBL:Q79FD9"
/protein_id="CCP45231.1"
/translation="MARTGHVQYRRGVGRRVTDGGVVSAGGNAHEPVLVGGVKVHRPF
IVAQRRQNARITRRVSTLDTVESPALLADGGIDRRGDATDWAAADPGP"
gene complement(2737117..2738247)
/gene="proB"
/locus_tag="Rv2439c"
CDS complement(2737117..2738247)
/codon_start=1
/transl_table=11
/gene="proB"
/locus_tag="Rv2439c"
/product="Probable glutamate 5-kinase protein ProB
(gamma-glutamyl kinase) (GK)"
/note="Rv2439c, (MTCY428.07), len: 376 aa. Probable
proB,glutamate 5-kinase protein (GK), equivalent to
Q9CBZ5|prob|ML1464 from Mycobacterium leprae (367 aa)
FASTA scores: opt: 1937, E(): 1.1e-102, (84.4% identity in
366 aa overlap). Also highly similar to other glutamate
5-kinase proteins e.g. P46546|PROB_CORGL from
Corynebacterium glutamicum (Brevibacterium flavum) (369
aa), FASTA scores: opt: 1241, E(): 3e-63, (54.35% identity
in 368 aa overlap); Q9ZG98|PROB_MEIRU glutamate 5-kinase
from Meiothermus ruber (390 aa), FASTA scores: opt: 825,
E(): 1.2e-39, (45.05% identity in 353 aa overlap);
Q9RDJ9|prob|SCC123.25c from Streptomyces coelicolor (374
aa), FASTA scores: opt: 1193,E(): 1.6e-60, (55.85%
identity in 367 aa overlap); etc. Contains PS00902
Glutamate 5-kinase signature. Belongs to the glutamate
5-kinase family."
/db_xref="EnsemblGenomes-Gn:Rv2439c"
/db_xref="EnsemblGenomes-Tr:CCP45232"
/db_xref="GOA:P9WHU9"
/db_xref="InterPro:IPR001048"
/db_xref="InterPro:IPR001057"
/db_xref="InterPro:IPR002478"
/db_xref="InterPro:IPR005715"
/db_xref="InterPro:IPR011529"
/db_xref="InterPro:IPR015947"
/db_xref="InterPro:IPR019797"
/db_xref="InterPro:IPR036393"
/db_xref="InterPro:IPR036974"
/db_xref="InterPro:IPR041739"
/db_xref="UniProtKB/Swiss-Prot:P9WHU9"
/inference="protein motif:PROSITE:PS00902"
/protein_id="CCP45232.1"
/translation="MRSPHRDAIRTARGLVVKVGTTALTTPSGMFDAGRLAGLAEAVE
RRMKAGSDVVIVSSGAIAAGIEPLGLSRRPKDLATKQAAASVGQVALVNSWSAAFARY
GRTVGQVLLTAHDISMRVQHTNAQRTLDRLRALHAVAIVNENDTVATNEIRFGDNDRL
SALVAHLVGADALVLLSDIDGLYDCDPRKTADATFIPEVSGPADLDGVVAGRSSHLGT
GGMASKVAAALLAADAGVPVLLAPAADAATALADASVGTVFAARPARLSARRFWVRYA
AEATGALTLDAGAVRAVVRQRRSLLAAGITAVSGRFCGGDVVELRAPDAAMVARGVVA
YDASELATMVGRSTSELPGELRRPVVHADDLVAVSAKQAKQV"
gene complement(2738247..2739686)
/gene="obg"
/locus_tag="Rv2440c"
CDS complement(2738247..2739686)
/codon_start=1
/transl_table=11
/gene="obg"
/locus_tag="Rv2440c"
/product="Probable GTP1/Obg-family GTP-binding protein
Obg"
/note="Rv2440c, (MTCY428.06), len: 479 aa. Probable
obg,nucleotide-binding protein, equivalent to
Q9CBZ4|ML1465 GTP1/OBG-family GTP-binding protein from
Mycobacterium leprae (478 aa), FASTA scores: opt: 1328,
E(): 8.4e-70,(58.9% identity in 479 aa overlap). Also
highly similar to others e.g. P95722|OBG GTP-binding
protein from Streptomyces coelicolor (478 aa), FASTA
scores: opt: 1311,E(): 8.2e-69, (60.7% identity in 476 aa
overlap); P20964|OBG_BACSU SPO0B-associated GTP-binding
protein from Bacillus subtilis (428 aa), FASTA scores:
opt: 1006, E(): 3.9e-51, (42.9% identity in 436 aa
overlap); Q9KDK0|OBG|BH1213 GTP-binding protein involved
in initiation of sporulation from Bacillus halodurans (427
aa), FASTA scores: opt: 978, E(): 1.7e-49, (41.95%
identity in 436 aa overlap); etc. Highly similar
(identical but shorter 5 aa) to AAK46813|MT2516
GTP-binding protein from Mycobacterium tuberculosis strain
CDC1551 (484 aa), FASTA scores: opt: 3205, E(): 7.9e-179,
(100% identity in 479 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
GTP1/OBG family."
/db_xref="EnsemblGenomes-Gn:Rv2440c"
/db_xref="EnsemblGenomes-Tr:CCP45233"
/db_xref="GOA:P9WMT1"
/db_xref="InterPro:IPR006073"
/db_xref="InterPro:IPR006074"
/db_xref="InterPro:IPR006169"
/db_xref="InterPro:IPR014100"
/db_xref="InterPro:IPR015349"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031167"
/db_xref="InterPro:IPR036346"
/db_xref="InterPro:IPR036726"
/db_xref="UniProtKB/Swiss-Prot:P9WMT1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45233.1"
/translation="MPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGG
SIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENG
RLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVA
DVGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIP
GASRGRGLGLDFLRHIERCAVLVHVVDCATAEPGRDPISDIDALETELACYTPTLQGD
AALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFG
LSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNF
DNDEAVGYLADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRG
TDPRLDSNKRVGAAERKAARSRRREHGDG"
gene complement(2739772..2740032)
/gene="rpmA"
/locus_tag="Rv2441c"
CDS complement(2739772..2740032)
/codon_start=1
/transl_table=11
/gene="rpmA"
/locus_tag="Rv2441c"
/product="50S ribosomal protein L27 RpmA"
/note="Rv2441c, (MTCY428.05), len: 86 aa. rpmA, 50S
ribosomal proteins L27, equivalent to Q9CBZ3|RL27_MYCLE
from Mycobacterium leprae (88 aa), FASTA scores: opt:
504,E(): 7.6e-28, (93.2% identity in 81 aa overlap). Also
highly similar to others e.g. P95757|RL27_STRGR from
Streptomyces griseus (85 aa), FASTA scores: opt: 442, E():
1.2e-23, (81.5% identity in 81 aa overlap); etc. Contains
PS00831 Ribosomal protein L27 signature. Belongs to the
L27P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv2441c"
/db_xref="EnsemblGenomes-Tr:CCP45234"
/db_xref="GOA:P9WHB3"
/db_xref="InterPro:IPR001684"
/db_xref="InterPro:IPR018261"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHB3"
/inference="protein motif:PROSITE:PS00831"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45234.1"
/translation="MAHKKGASSSRNGRDSAAQRLGVKRYGGQVVKAGEILVRQRGTK
FHPGVNVGRGGDDTLFAKTAGAVEFGIKRGRKTVSIVGSTTA"
gene complement(2740047..2740361)
/gene="rplU"
/locus_tag="Rv2442c"
CDS complement(2740047..2740361)
/codon_start=1
/transl_table=11
/gene="rplU"
/locus_tag="Rv2442c"
/product="50S ribosomal protein L21 RplU"
/note="Rv2442c, (MTCY428.04), len: 104 aa. rplU, 50S
ribosomal protein L21, equivalent to Q9CBZ2|RL21_MYCLE
from Mycobacterium leprae (103 aa), FASTA scores: opt:
579, E(): 4.8e-31, (91.1% identity in 102 aa overlap).
Also highly similar to others e.g. P95756|RL21_STRGR from
Streptomyces griseus (106 aa), FASTA scores: opt: 362,
E(): 5.4e-17,(56.0% identity in 100 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2442c"
/db_xref="EnsemblGenomes-Tr:CCP45235"
/db_xref="GOA:P9WHC3"
/db_xref="InterPro:IPR001787"
/db_xref="InterPro:IPR018258"
/db_xref="InterPro:IPR028909"
/db_xref="InterPro:IPR036164"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHC3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45235.1"
/translation="MMATYAIVKTGGKQYKVAVGDVVKVEKLESEQGEKVSLPVALVV
DGATVTTDAKALAKVAVTGEVLGHTKGPKIRIHKFKNKTGYHKRQGHRQQLTVLKVTG
IA"
gene 2740709..2742184
/gene="dctA"
/locus_tag="Rv2443"
CDS 2740709..2742184
/codon_start=1
/transl_table=11
/gene="dctA"
/locus_tag="Rv2443"
/product="Probable C4-dicarboxylate-transport
transmembrane protein DctA"
/note="Rv2443, (MTCY428.03c), len: 491 aa. Probable
dctA,C4-dicarboxylate-transport transmembrane protein,
similar to other C4-dicarboxylate transport proteins e.g.
AAK46817|MT2519 from Mycobacterium tuberculosis strain
CDC1551 (491 aa); Q9L1K8|SC6A11.12 putative
sodium:dicarboxylate symporter from Streptomyces
coelicolor (466 aa), FASTA scores: opt: 1797, E():
2.9e-98, (61.3% identity in 452 aa overlap); Q9RRG7|DR2525
from Deinococcus radiodurans (463 aa); P50334|DCTA_SALTY
from Salmonella typhimurium (428 aa) FASTA scores: opt:
1241, E(): 1.3e-65,(47.2% identity in 415 aa overlap);
etc. Belongs to the sodium dicarboxylate symporter family
(SDF) (DAACS family)."
/db_xref="EnsemblGenomes-Gn:Rv2443"
/db_xref="EnsemblGenomes-Tr:CCP45236"
/db_xref="GOA:P71906"
/db_xref="InterPro:IPR001991"
/db_xref="InterPro:IPR036458"
/db_xref="UniProtKB/TrEMBL:P71906"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45236.1"
/translation="MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTA
PSTGKSLTVLGTVFVNLIKMMIAPVIFCTIVLGIGSVRKAAAVGKVGGLALAYFLTMS
SVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESHGIAGFIQQIIPRSLPSA
LTEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKLVFKVLVMVLWLAPIGAFG
AIANIVATTGFNAVTNLLLLMAGFYLTCVVFVFGVLGVLLRIVSGLSIFRLLRYLARE
YLLIFATSSSEVVLPRLITKMKHLGVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIA
DAMGHRLTWGEQIALLAFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGI
DRFMSEARSLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMVDPHDEEP
PAATPHGGGVPTNPALCDFEQVSLGGLVGRPAGPQRADVDG"
gene complement(2742123..2744984)
/gene="rne"
/locus_tag="Rv2444c"
CDS complement(2742123..2744984)
/codon_start=1
/transl_table=11
/gene="rne"
/locus_tag="Rv2444c"
/product="Possible ribonuclease E Rne"
/note="Rv2444c, (MTCY428.02), len: 953 aa. Possible
rne,ribonuclease E, highly similar to others e.g.
Q9CBZ1|ML1468 possible ribonuclease from Mycobacterium
leprae (924 aa),FASTA scores: opt: 3713, E(): 2.4e-174,
(74.2% identity in 966 aa overlap); Q9SI08|AT2G04270
putative ribonuclease E from Arabidopsis thaliana (502
aa), FASTA scores: opt: 674,E(): 7.5e-26, (31.2% identity
in 410 aa overlap); etc. Similar at C-terminal end to
P21513|RNE_ECOLI|ams|HMP1|B1084 ribonuclease E (RNASE E)
from Escherichia coli strain K12 (1061 aa), FASTA scores:
opt: 554, E(): 9.9e-20, (37.8% identity in 386 aa
overlap). Also similar in medium part to several
cytoplasmic axial filament proteins e.g.
Q9HVU4|CAFA|PA4477 from Pseudomonas aeruginosa (485 aa),
FASTA scores: opt: 664, E(): 2.3e-25,(42.8% identity in
418 aa overlap); etc. Equivalent to AAK46818 from
Mycobacterium tuberculosis strain CDC1551 (621 aa) but
longer 332 aa in N-terminal part. Seems to belong to the
RNE family."
/db_xref="EnsemblGenomes-Gn:Rv2444c"
/db_xref="EnsemblGenomes-Tr:CCP45237"
/db_xref="GOA:P71905"
/db_xref="InterPro:IPR003029"
/db_xref="InterPro:IPR004659"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR019307"
/db_xref="InterPro:IPR022967"
/db_xref="UniProtKB/TrEMBL:P71905"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45237.1"
/translation="MIDGAPPSDPPEPSQHEELPDRLRVHSLARTLGTTSRRVLDALT
ALDGRVRSAHSTVDRVDAVRVRDLLATHLETAGVLAASVHAPEASEEPESRLMLETQE
TRNADVERPHYMPLFVAPQPIPEPLADDEDVDDGPDYVADDSDADDEGQLDRPANRRR
RRGRRGRGRGRGEQGGSDGDPVDQQSEPRAQQFTSADAAETDDGDDRDSEDTEAGDNG
EDENGSLEAGNRRRRRRRRRKSASGDDNDAALEGPLPDDPPNTVVHERVPRAGDKAGN
SQDGGSGSTEIKGIDGSTRLEAKRQRRRDGRDAGRRRPPVLSEAEFLARREAVERVMV
VRDRVRTEPPLPGTRYTQIAVLEDGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEA
AFVDIGRGRNGVLYAGEVNWDAAGLGGADRKIEQALKPGDYVVVQVSKDPVGHKGARL
TTQVSLAGRFLVYVPGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEGVK
EDDIRADVARLRERWEQIEAKAQETKEKAAGAAVALYEEPDVLVKVIRDLFNEDFVGL
IVSGDEAWNTINEYVNSVAPELVSKLTKYESADGPDGQSAPDVFTVHRIDEQLAKAMD
RKVWLPSGGTLVIDRTEAMTVIDVNTGKFTGAGGNLEQTVTKNNLEAAEEIVRQLRLR
DIGGIVVIDFIDMVLESNRDLVLRRLTESLARDRTRHQVSEVTSLGLVQLTRKRLGTG
LIEAFSTSCPNCSGRGILLHADPVDSAAATGRKSEPGARRGKRSKKSRSEESSDRSMV
AKVPVHAPGEHPMFKAMAAGLSSLAGRGDEESGEPAAELAEQAGDQPPTDLDDTAQAD
FEDTEDTDEDEDELDADEDLEDLDDEDLDEDLDVEDSDSDDEDSDEDAADADVDEEDA
AGLDGSPGEVDVPGVTELAPTRPRRRVAGRPAGPPIRLD"
gene complement(2745314..2745724)
/gene="ndkA"
/gene_synonym="ndk"
/locus_tag="Rv2445c"
CDS complement(2745314..2745724)
/codon_start=1
/transl_table=11
/gene="ndkA"
/gene_synonym="ndk"
/locus_tag="Rv2445c"
/product="Probable nucleoside diphosphate kinase NdkA
(NDK) (NDP kinase) (nucleoside-2-P kinase)"
/note="Rv2445c, (MTV008.01c, MTCY428.01), len: 136 aa.
Probable ndkA (alternate gene name: ndk), nucleoside
diphosphate kinase, equivalent to Q9CBZ0|NDK|ML1469 from
Mycobacterium leprae (136 aa), FASTA scores: opt: 762,
E(): 1.5e-42, (87.4% identity in 135 aa overlap); and
O85501|NDK from Mycobacterium smegmatis (139 aa), FASTA
scores: opt: 714, E(): 1.9e-39, (80.7% identity in 135 aa
overlap). Also highly similar to others e.g.
P50589|NDK_STRCO from Streptomyces coelicolor (137 aa),
FASTA scores: opt: 535,6.8e-28, (60.3% identity in 136 aa
overlap); O29491|NDK_ARCFU|AF0767 from Archaeoglobus
fulgidus (151 aa), FASTA scores: opt: 521, E(): 5.9e-27,
(58.0% identity in 131 aa overlap); P31103|NDK_BACSU from
Bacillus subtilis (151 aa), FASTA scores: opt: 515, E():
1.4e-26, (56.5% identity in 131 aa overlap); etc. Belongs
to the NDK family. Ppk2|Rv3232c and NdkA|Rv2445c interact
(See Sureka et al., 2009)."
/db_xref="EnsemblGenomes-Gn:Rv2445c"
/db_xref="EnsemblGenomes-Tr:CCP45238"
/db_xref="GOA:P9WJH7"
/db_xref="InterPro:IPR001564"
/db_xref="InterPro:IPR034907"
/db_xref="InterPro:IPR036850"
/db_xref="PDB:1K44"
/db_xref="PDB:4ANC"
/db_xref="PDB:4AND"
/db_xref="PDB:4ANE"
/db_xref="UniProtKB/Swiss-Prot:P9WJH7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45238.1"
/translation="MTERTLVLIKPDGIERQLIGEIISRIERKGLTIAALQLRTVSAE
LASQHYAEHEGKPFFGSLLEFITSGPVVAAIVEGTRAIAAVRQLAGGTDPVQAAAPGT
IRGDFALETQFNLVHGSDSAESAQREIALWFPGA"
gene complement(2745767..2746138)
/locus_tag="Rv2446c"
CDS complement(2745767..2746138)
/codon_start=1
/transl_table=11
/locus_tag="Rv2446c"
/product="Probable conserved integral membrane protein"
/note="Rv2446c, (MTV008.02c), len: 123 aa. Probable
conserved integral membrane protein, highly similar to
Q9CBY9|ML1470 conserved membrane protein from
Mycobacterium leprae (123 aa), FASTA scores: opt: 468,
E(): 6.7e-23,(66.65% identity in 108 aa overlap). Also
similar to Q9L1G5|SCC88.24c putative membrane protein from
Streptomyces coelicolor (118 aa), FASTA scores: opt:
130,E(): 0.13, (37.2% identity in 86 aa overlap); and some
similarity to O06852|Y13070 hypothetical Streptomyces
coelicolor gene also between fpgs and ndk genes (see
citation below) (117 aa), FASTA scores: opt: 128, E():
0.17, (36.0% identity in 86 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2446c"
/db_xref="EnsemblGenomes-Tr:CCP45239"
/db_xref="GOA:O53173"
/db_xref="InterPro:IPR025327"
/db_xref="UniProtKB/TrEMBL:O53173"
/protein_id="CCP45239.1"
/translation="MTDRSREPADPWKGFSAVMAATLILEAIVVLLAIPVVDAVGGGL
RPASLGYLVGLAVLLILLTGLQRRPWAIWVNLGAQPVLVAGFAVYPGVGFIGVLFAAL
WVLIAYLRAEVRRRRDYRVSQ"
gene complement(2746135..2747598)
/gene="folC"
/locus_tag="Rv2447c"
CDS complement(2746135..2747598)
/codon_start=1
/transl_table=11
/gene="folC"
/locus_tag="Rv2447c"
/product="Probable folylpolyglutamate synthase protein
FolC (folylpoly-gamma-glutamate synthetase) (FPGS)"
/note="Rv2447c, (MTV008.03c), len: 487 aa. Probable
folC,folylpolyglutamate synthase, equivalent to
Q9CBY8|FOLC|ML1471 from Mycobacterium leprae (485
aa),FASTA scores: opt: 2425, E(): 2.2e-134, (78.7%
identity in 483 aa overlap). Also highly similar to others
e.g. Q9L1G4|FPGS|O08416|Y13070 from Streptomyces
coelicolor (444 aa), FASTA scores: opt: 774, E(): 6.3e-38,
(53.9% identity in 462 aa overlap); P15925|FOLC_LACCA|FGS
from Lactobacillus casei (428 aa), FASTA scores: opt: 631,
E(): 1.4e-29, (34.55% identity in 437 aa overlap);
Q05865|FOLC_BACSU from Bacillus subtilis (430 aa), FASTA
scores: opt: 421, E(): 2.6e-17, (32.9% identity in 383 aa
overlap); etc. Contains PS01012 Folylpolyglutamate
synthase signature 2. Belongs to the folylpolyglutamate
synthase family."
/db_xref="EnsemblGenomes-Gn:Rv2447c"
/db_xref="EnsemblGenomes-Tr:CCP45240"
/db_xref="GOA:I6Y0R5"
/db_xref="InterPro:IPR001645"
/db_xref="InterPro:IPR004101"
/db_xref="InterPro:IPR013221"
/db_xref="InterPro:IPR018109"
/db_xref="InterPro:IPR036565"
/db_xref="InterPro:IPR036615"
/db_xref="PDB:2VOR"
/db_xref="PDB:2VOS"
/db_xref="UniProtKB/Swiss-Prot:I6Y0R5"
/inference="protein motif:PROSITE:PS01012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45240.1"
/translation="MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRID
PSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQ
SPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAF
AAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAG
IITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQV
LQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVT
SPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILA
ALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDA
AADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ"
gene complement(2747595..2750225)
/gene="valS"
/locus_tag="Rv2448c"
CDS complement(2747595..2750225)
/codon_start=1
/transl_table=11
/gene="valS"
/locus_tag="Rv2448c"
/product="Probable valyl-tRNA synthase protein ValS
(valyl-tRNA synthetase) (valine--tRNA ligase) (valine
translase)"
/note="Rv2448c, (MTV008.04c), len: 876 aa. Probable
valS,valyl-tRNA synthetases, equivalent to
Q9CBY7|VALS|ML1472 valyl-tRNA synthase from Mycobacterium
leprae (886 aa),FASTA scores: opt: 5181,E(): 0, (85.4%
identity in 876 aa overlap). Also highly similar to others
e.g. O06851|SYV_STRCO from Streptomyces coelicolor (874
aa),FASTA scores: opt: 2470, E(): 1.6e-143, (60.45%
identity in 880 aa overlap); Q9X2D7|SYV_THEMA|VALS|TM1817
from Thermotoga maritima (865 aa), FASTA scores: opt:
2418, E(): 2.4e-140, (44.2% identity in 891 aa overlap);
Q05873|SYV_BACSU|VALS from Bacillus subtilis (880
aa),FASTA scores: opt: 2063, E(): 1.4e-118, (46.08%
identity in 894 aa overlap); etc. Contains PS00178
Aminoacyl-transfer RNA synthetases class-I signature.
Contains probable coiled-coil from aa 810 to 846. Belongs
to class-I aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2448c"
/db_xref="EnsemblGenomes-Tr:CCP45241"
/db_xref="GOA:P9WFS9"
/db_xref="InterPro:IPR001412"
/db_xref="InterPro:IPR002300"
/db_xref="InterPro:IPR002303"
/db_xref="InterPro:IPR009008"
/db_xref="InterPro:IPR009080"
/db_xref="InterPro:IPR010978"
/db_xref="InterPro:IPR013155"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR019499"
/db_xref="InterPro:IPR033705"
/db_xref="InterPro:IPR037118"
/db_xref="UniProtKB/Swiss-Prot:P9WFS9"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45241.1"
/translation="MLPKSWDPAAMESAIYQKWLDAGYFTADPTSTKPAYSIVLPPPN
VTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGTDHAGIATQSVVEQQLAVDGKTK
EDLGRELFVDKVWDWKRESGGAIGGQMRRLGDGVDWSRDRFTMDEGLSRAVRTIFKRL
YDAGLIYRAERLVNWSPVLQTAISDLEVNYRDVEGELVSFRYGSLDDSQPHIVVATTR
VETMLGDTAIAVHPDDERYRHLVGTSLAHPFVDRELAIVADEHVDPEFGTGAVKVTPA
HDPNDFEIGVRHQLPMPSILDTKGRIVDTGTRFDGMDRFEARVAVRQALAAQGRVVEE
KRPYLHSVGHSERSGEPIEPRLSLQWWVRVESLAKAAGDAVRNGDTVIHPASMEPRWF
SWVDDMHDWCISRQLWWGHRIPIWYGPDGEQVCVGPDETPPQGWEQDPDVLDTWFSSA
LWPFSTLGWPDKTAELEKFYPTSVLVTGYDILFFWVARMMMFGTFVGDDAAITLDGRR
GPQVPFTDVFLHGLIRDESGRKMSKSKGNVIDPLDWVEMFGADALRFTLARGASPGGD
LAVSEDAVRASRNFGTKLFNATRYALLNGAAPAPLPSPNELTDADRWILGRLEEVRAE
VDSAFDGYEFSRACESLYHFAWDEFCDWYLELAKTQLAQGLTHTTAVLAAGLDTLLRL
LHPVIPFLTEALWLALTGRESLVSADWPEPSGISVDLVAAQRINDMQKLVTEVRRFRS
DQGLADRQKVPARMHGVRDSDLSNQVAAVTSLAWLTEPGPDFEPSVSLEVRLGPEMNR
TVVVELDTSGTIDVAAERRRLEKELAGAQKELASTAAKLANADFLAKAPDAVIAKIRD
RQRVAQQETERITTRLAALQ"
gene complement(2750313..2751572)
/locus_tag="Rv2449c"
CDS complement(2750313..2751572)
/codon_start=1
/transl_table=11
/locus_tag="Rv2449c"
/product="Conserved protein"
/note="Rv2449c, (MTV008.05c), len: 419 aa. Conserved
protein, highly similar to hypothetical proteins e.g.
P95139|Rv2953|MTCY349.37c from M. tuberculosis (418
aa),FASTA scores: opt: 1829, E(): 4.7e-103, (67.3%
identity in 419 aa overlap); AAK47353|MT3027 from
Mycobacterium tuberculosis strain CDC1551 (418 aa), FASTA
score: opt: 1829, E(): 4.7e-103, (67.3 identity in 419 aa
overlap); Q9CD87|ML0129 from Mycobacterium leprae (418
aa), FASTA scores: opt: 1727, E(): 6.8e-97, (65.45%
identity in 414 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2449c"
/db_xref="EnsemblGenomes-Tr:CCP45242"
/db_xref="GOA:O53176"
/db_xref="InterPro:IPR005097"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:O53176"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45242.1"
/translation="MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQ
RVLAVREALGESAQTWPILTADASLPSTLQAMAARAQVVVTTVGPYTRYGLPLVAACA
AAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAARE
DGAGELTDTNCVVRSFKGGFSGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAE
PELGPQPDLPSRRGRRLAPELAGVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSE
TMSVGSTVLAPVVSVVGGGVGNAMFGLASRYIRLLPRGLVKRVVPKPGTGPSAAARER
GYYRIETYTTTTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLT
PAAAMGDALLERLPAAGVSLQTTRLAS"
gene complement(2751662..2752180)
/gene="rpfE"
/locus_tag="Rv2450c"
CDS complement(2751662..2752180)
/codon_start=1
/transl_table=11
/gene="rpfE"
/locus_tag="Rv2450c"
/product="Probable resuscitation-promoting factor RpfE"
/note="Rv2450c, (MTV008.06c), len: 172 aa. Probable
rpfE,resuscitation-promoting factor (see Mukamolova et
al.,1998), similar to O86308|Z96935|MLRPF_1 RPF protein
precursor from Micrococcus luteus (220 aa), FASTA scores:
opt: 291, E(): 3e-7, (48.75% identity in 80 aa overlap).
C-terminus is similar to other Mycobacterial rpf proteins
e.g. O05594|Rv1009|MTCI237.26|RPFB probable
resuscitation-promoting factor from Mycobacterium
tuberculosis (362 aa), FASTA scores: opt: 344, E():
1.4e-09, (42.85% identity in 147 aa overlap); etc.
C-terminal region similar to N-terminal region of
Q9F2Q2|SCE41.06c putative secreted protein from
Streptomyces coelicolor (244 aa), FASTA scores: opt:
355,E(): 3.1e-10, (56.65% identity in 90 aa overlap). Also
similar to Q9F2Q1|SCE41.07c putative secreted protein from
Streptomyces coelicolor (near Q9F2Q2|SCE41.06c) (341 aa)
FASTA scores: opt: 317, E(): 2.5e-08, (51.7% identity in
87 aa overlap). With Mycobacterium leprae, high similarity
between the two corresponding C-terminal regions of two
hypothetical proteins, Q9CD53|ML0240 (375 aa), FASTA
scores: opt: 339, E(): 2.5e-09, (59.15% identity in 93 aa
overlap) and O33049|MLCB57.05c|ML2151 (174 aa), FASTA
scores: opt: 329, E(): 4e-09, (58.14% identity in 86 aa
overlap). Contains a possible secretory signal sequence in
N-terminus. Possible autocrine and/or paracrine bacterial
growth factor or cytokine (see citations below). Interacts
with RipA (see Hett et al., 2007). Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2450c"
/db_xref="EnsemblGenomes-Tr:CCP45243"
/db_xref="GOA:O53177"
/db_xref="InterPro:IPR010618"
/db_xref="InterPro:IPR023346"
/db_xref="PDB:4CGE"
/db_xref="UniProtKB/Swiss-Prot:O53177"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45243.1"
/translation="MKNARTTLIAAAIAGTLVTTSPAGIANADDAGLDPNAAAGPDAV
GFDPNLPPAPDAAPVDTPPAPEDAGFDPNLPPPLAPDFLSPPAEEAPPVPVAYSVNWD
AIAQCESGGNWSINTGNGYYGGLRFTAGTWRANGGSGSAANASREEQIRVAENVLRSQ
GIRAWPVCGRRG"
gene 2752262..2752660
/locus_tag="Rv2451"
CDS 2752262..2752660
/codon_start=1
/transl_table=11
/locus_tag="Rv2451"
/product="Hypothetical proline and serine rich protein"
/note="Rv2451, (MTV008.07), len: 132 aa. Hypothetical
unknown pro-, ser-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv2451"
/db_xref="EnsemblGenomes-Tr:CCP45244"
/db_xref="GOA:O53178"
/db_xref="UniProtKB/TrEMBL:O53178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45244.1"
/translation="MGRAVSVRHGSGALDLPGAAASRRLRVGQPIQPSPAPLARGSVD
SIVEISCCPSAGPRGPYDNDLDSSSPANRDISSITSRSRRGGTIVVAGQKCGFGSAVS
LRPRRYREPNHANIVTPDTDLSPSWPWSGI"
gene complement(2752848..2752994)
/locus_tag="Rv2452c"
CDS complement(2752848..2752994)
/codon_start=1
/transl_table=11
/locus_tag="Rv2452c"
/product="Hypothetical protein"
/note="Rv2452c, (MTV008.08c), len: 48 aa. Hypothetical
unknown protein (see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv2452c"
/db_xref="EnsemblGenomes-Tr:CCP45245"
/db_xref="GOA:O53179"
/db_xref="UniProtKB/TrEMBL:O53179"
/protein_id="CCP45245.1"
/translation="MAFRDILVLFSMKTLLTLAMAAASSTALTTVGVSGARLITYCVG
VEDI"
gene complement(2753018..2753623)
/gene="mobA"
/locus_tag="Rv2453c"
CDS complement(2753018..2753623)
/codon_start=1
/transl_table=11
/gene="mobA"
/locus_tag="Rv2453c"
/product="Probable molybdopterin-guanine dinucleotide
biosynthesis protein A MobA"
/note="Rv2453c, (MT2528, MTV008.09c), len: 201 aa.
Probable mobA, molybdopterin-guanine dinucleotide
biosynthesis protein A, similar to others e.g. Q9F8G7 from
Carboxydothermus hydrogenoformans (224 aa), FASTA scores:
opt: 249, E(): 3.9e-08, (30.6% identity in 173 aa
overlap); P95645|MOBA_RHOSH|mob|Y09560 from Rhodobacter
sphaeroides (199 aa), FASTA scores: opt: 240, E():
1.2e-07, (33.9% identity in 186 aa overlap);
Q9X7K0|MOBA_RHOCA from Rhodobacter capsulatus
(Rhodopseudomonas capsulata) (191 aa), FASTA scores: opt:
217, E(): 2.9e-06, (37.4% identity in 123 aa overlap);
etc. Belongs to the MobA family."
/db_xref="EnsemblGenomes-Gn:Rv2453c"
/db_xref="EnsemblGenomes-Tr:CCP45246"
/db_xref="GOA:P9WJQ9"
/db_xref="InterPro:IPR013482"
/db_xref="InterPro:IPR025877"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WJQ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45246.1"
/translation="MAELAPDTVPLAGVVLAGGESRRMGRDKATLPLPGGTTTLVEHM
VGILGQRCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATGRGLRAAAEAGVRLAF
VCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAG
ERKMSALVDASDALRIVMADSRPLTNVNSAAGLHAPMQPGR"
gene complement(2753625..2754746)
/locus_tag="Rv2454c"
CDS complement(2753625..2754746)
/codon_start=1
/transl_table=11
/locus_tag="Rv2454c"
/product="Probable oxidoreductase (beta subunit)"
/note="Rv2454c, (MTV008.10c), len: 373 aa. Probable
oxidoreductase, beta subunit, similar to Q9F2W7|SCD20.12c
putative oxidoreductase from Streptomyces coelicolor (352
aa), FASTA scores: opt: 1461, E(): 6.4e-85, (65.3%
identity in 343 aa overlap) alias Q9RKS5|STAH10.34c
putative oxidoreductase beta-subunit from Streptomyces
coelicolor (350 aa), FASTA scores: opt: 1429, E():
6.7e-83, (64.0% identity in 342 aa overlap); and similar
in part to others e.g. Q9Z5X3 ferredoxin oxidoreductase
B-subunit from Frankia sp. (346 aa), FASTA scores: opt:
1143, E(): 7.5e-65, (51.2% identity in 336 aa overlap);
BAB21495|KORB ferredoxin oxidoreductase beta subunit from
Hydrogenobacter thermophilus TK-6 (295 aa), FASTA scores:
opt: 682, E(): 8.3e-36, (48.25% identity in 201 aa
overlap); etc. Note that the upstream ORF
(MTV008.11c|Rv2455c) is possibly an oxidoreductase alpha
subunit."
/db_xref="EnsemblGenomes-Gn:Rv2454c"
/db_xref="EnsemblGenomes-Tr:CCP45247"
/db_xref="GOA:O53181"
/db_xref="InterPro:IPR011766"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/Swiss-Prot:O53181"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45247.1"
/translation="MTRSGDEAQLMTGVTGDLAGTELGLTPSLTKNAGVPTTDQPQKG
KDFTSDQEVRWCPGCGDYVILNTIRNFLPELGLRRENIVFISGIGCSSRFPYYLETYG
FHSIHGRAPAIATGLALAREDLSVWVVTGDGDALSIGGNHLIHALRRNINVTILLFNN
RIYGLTKGQYSPTSEVGKVTKSTPMGSLDHPFNPVSLALGAEATFVGRALDSDRNGLT
EVLRAAAQHRGAALVEILQDCPIFNDGSFDALRKEGAEERVIKVRHGEPIVFGANGEY
CVVKSGFGLEVAKTADVAIDEIIVHDAQVDDPAYAFALSRLSDQNLDHTVLGIFRHIS
RPTYDDAARSQVVAARNAAPSGTAALQSLLHGRDTWTVD"
gene complement(2754743..2756704)
/locus_tag="Rv2455c"
CDS complement(2754743..2756704)
/codon_start=1
/transl_table=11
/locus_tag="Rv2455c"
/product="Probable oxidoreductase (alpha subunit)"
/note="Rv2455c, (MTV008.11c), len: 653 aa. Probable
oxidoreductase, alpha subunit, similar to others e.g.
Q9F2W6|SCD20.13c putative oxidoreductase from Streptomyces
coelicolor (645 aa), FASTA scores: opt: 2017, E():
1e-111,(66.45% identity in 617 aa overlap) alias
Q9RKS4|STAH10.35c putative oxidoreductase alpha-subunit
from Streptomyces coelicolor (630 aa), FASTA scores: opt:
2008, E(): 3.4e-111, (66.45% identity in 614 aa overlap);
Q9YA13|APE2126 long hypothetical 2-oxoacid--ferredoxin
oxidoreductase alpha chain from Aeropyrum pernix (644 aa)
FASTA scores: opt: 687, E(): 4.6e-33, (33.35% identity in
441 aa overlap); etc. Note that the downstream ORF
(MTV008.10c|Rv2454c) is possibly an oxidoreductase beta
subunit."
/db_xref="EnsemblGenomes-Gn:Rv2455c"
/db_xref="EnsemblGenomes-Tr:CCP45248"
/db_xref="GOA:O53182"
/db_xref="InterPro:IPR002869"
/db_xref="InterPro:IPR002880"
/db_xref="InterPro:IPR009014"
/db_xref="InterPro:IPR019752"
/db_xref="InterPro:IPR022367"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR033412"
/db_xref="UniProtKB/Swiss-Prot:O53182"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45248.1"
/translation="MDPNGSGAGPESHDAAFHAAPDRQRLENVVIRFAGDSGDGMQLT
GDRFTSEAALFGNDLATQPNYPAEIRAPAGTLPGVSSFQIQIADYDILTAGDRPDVLV
AMNPAALKANIGDLPLGGMVIVNSDEFTKRNLTKVGYVTNPLESGELSDYVVHTVAMT
TLTLGAVEAIGASKKDGQRAKNMFALGLLSWMYGRELEHSEAFIREKFARKPEIAEAN
VLALKAGWNYGETTEAFGTTYEIPPATLPPGEYRQISGNTALAYGIVVAGQLAGLPVV
LGSYPITPASDILHELSKHKNFNVVTFQAEDEIGGICAALGAAYGGALGVTSTSGPGI
SLKSEALGLGVMTELPLLVIDVQRGGPSTGLPTKTEQADLLQALYGRNGESPVAVLAP
RSPADCFETALEAVRIAVSYHTPVILLSDGAIANGSEPWRIPDVNALPPIKHTFAKPG
EPFQPYARDRETLARQFAIPGTPGLEHRIGGLEAANGSGDISYEPTNHDLMVRLRQAK
IDGIHVPDLEVDDPTGDAELLLIGWGSSYGPIGEACRRARRRGTKVAHAHLRYLNPFP
ANLGEVLRRYPKVVAPELNLGQLAQVLRGKYLVDVQSVTKVKGVSFLADEIGRFIRAA
LAGRLAELEQDKTLVARLSAATAGAGANG"
gene complement(2756936..2758192)
/locus_tag="Rv2456c"
CDS complement(2756936..2758192)
/codon_start=1
/transl_table=11
/locus_tag="Rv2456c"
/product="Probable conserved integral membrane transport
protein"
/note="Rv2456c, (MTV008.12c), len: 418 aa. Probable
conserved integral membrane transport protein, involved in
a efflux system, weakly similar to many e.g.
Q9RUR0|YD22_DEIRA|DR1322 putative sugar efflux transporter
from Deinococcus radiodurans (389 aa), FASTA scores: opt:
224, E(): 8.4e-06, (24.45% identity in 409 aa overlap);
Q9UYY0|PAB0913 multidrug resistance protein from
Pyrococcus abyssi (410 aa), FASTA scores: opt: 210, E():
5.6e-05,(21.8% identity in 408 aa overlap); etc. Contains
PS00216 Sugar transport proteins signature 1."
/db_xref="EnsemblGenomes-Gn:Rv2456c"
/db_xref="EnsemblGenomes-Tr:CCP45249"
/db_xref="GOA:P9WJX1"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJX1"
/inference="protein motif:PROSITE:PS00216"
/protein_id="CCP45249.1"
/translation="MSGTVVAVPPRVARALDLLNFSLADVRDGLGPYLSIYLLLIHDW
DQASIGFVMAVGGIAAIVAQTPIGALVDRTTAKRALVVAGAVLVTAAAVAMPLFAGLY
SISVLQAVTGIASSVFAPALAAITLGAVGPQFFARRIGRNEAFNHAGNASAAGATGAL
AYFFGPVVVFWVLAGMALISVLATLRIPPDAVDHDLARGMDHAPGEPHPQPSRFTVLA
HNRELVIFGAAVVAFHFANAAMLPLVGELLALHNRDEGTALMSSCIVAAQVVMVPVAY
VVGTRADAWGRKPIFLVGFAVLTARGFLYTLSDNSYWLVGVQLLDGIGAGIFGALFPL
VVQDVTHGTGHFNISLGAVTTATGIGAALSNLVAGWIVVVAGYDAAFMSLGALAGAGF
LLYLVAMPETVDSDVRVRSRPTLGGK"
gene complement(2758208..2759488)
/gene="clpX"
/locus_tag="Rv2457c"
CDS complement(2758208..2759488)
/codon_start=1
/transl_table=11
/gene="clpX"
/locus_tag="Rv2457c"
/product="Probable ATP-dependent CLP protease ATP-binding
subunit ClpX"
/note="Rv2457c, (MTV008.13c), len: 426 aa. Probable
clpX,ATP-dependent clp protease ATP-binding subunit
clpX,equivalent to Q9CBY6|CLPX|ML1477 ATP-dependent CLP
protease ATP-binding protein from Mycobacterium leprae
(426 aa),FASTA scores: opt: 2652, E(): 1.4e-142, (96.0%
identity in 426 aa overlap). Also highly similar to others
e.g. Q9F316|CLPX from Streptomyces coelicolor (428 aa)
FASTA scores: opt: 2178, E(): 8.2e-116, (77.8% identity in
428 aa overlap); P50866|CLPX_BACSU from Bacillus subtilis
(420 aa), FASTA scores: opt: 1788, E(): 8.5e-94, (63.6%
identity in 426 aa overlap); P33138|CLPX_ECOLI from
Escherichia coli (423 aa), FASTA scores: opt: 1694, E():
1.7e-88, (62.4% identity in 415 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the CLPX chaperone family. Conserved in M. tuberculosis,
M. leprae,M. bovis and M. avium paratuberculosis;
predicted to be essential for in vivo survival and
pathogenicity (See Ribeiro-Guimaraes and Pessolani,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv2457c"
/db_xref="EnsemblGenomes-Tr:CCP45250"
/db_xref="GOA:P9WPB9"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR004487"
/db_xref="InterPro:IPR010603"
/db_xref="InterPro:IPR019489"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR038366"
/db_xref="UniProtKB/Swiss-Prot:P9WPB9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45250.1"
/translation="MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNE
IIEEELADADDVKLDELPKPAEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGEKG
RDSRCEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDV
ENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILE
GTQASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVR
SKAEIDTTDHFADVMPEDLIKFGLIPEFIGRLPVVASVTNLDKESLVKILSEPKNALV
KQYIRLFEMDGVELEFTDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDD
VAKVVVTKETVQDNVLPTIVPRKPSRSERRDKSA"
gene 2759779..2760687
/gene="mmuM"
/locus_tag="Rv2458"
CDS 2759779..2760687
/codon_start=1
/transl_table=11
/gene="mmuM"
/locus_tag="Rv2458"
/product="Probable homocysteine S-methyltransferase MmuM
(S-methylmethionine:homocysteine methyltransferase)
(cysteine methyltransferase)"
/note="Rv2458, (MTV008.14), len: 302 aa. Probable
mmuM,homocysteine S-methyltransferase, equivalent to
Q9CBY5|ML1478 possible transferase from Mycobacterium
leprae (293 aa), FASTA scores: opt: 1507, E():
2.7e-86,(78.85% identity in 293 aa overlap). Also similar
to others e.g. Q47690|MMUM_ECOLI|B0261 homocysteine
S-methyltransferase from Escherichia coli strain K12 (310
aa), FASTA scores: opt: 863, E(): 2.4e-46, (47.65%
identity in 298 aa overlap); Q9FUM7 homocysteine
S-methyltransferase-4 from Zea mays (Maize) (342 aa),
FASTA scores: opt: 324, E(): 6.8e-13, (44.45% identity in
306 aa overlap); Q9LUI7|HMT3 cysteine methyltransferase
from Arabidopsis thaliana (Mouse-ear cress) (347 aa),
FASTA scores: opt: 312, E(): 3.8e-12, (41.85% identity in
313 aa overlap); etc. Identical to AAK46833|MT2533
homocysteine S-methyltransferase from Mycobacterium
tuberculosis strain CDC1551 (302 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2458"
/db_xref="EnsemblGenomes-Tr:CCP45251"
/db_xref="GOA:O53185"
/db_xref="InterPro:IPR003726"
/db_xref="InterPro:IPR017226"
/db_xref="InterPro:IPR036589"
/db_xref="UniProtKB/TrEMBL:O53185"
/protein_id="CCP45251.1"
/translation="MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAIT
AVHTAYFRAGAQIATTASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGG
LSVAASVGPYGAALADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDI
DEAEALVNLVRRLATPAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPD
DVLPAIAFAVAHTGKPVIVYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARI
VGGCCRVRPIDIAEIGRALTTAPPRG"
gene 2760854..2762380
/locus_tag="Rv2459"
CDS 2760854..2762380
/codon_start=1
/transl_table=11
/locus_tag="Rv2459"
/product="Probable conserved integral membrane transport
protein"
/note="Rv2459, (MTV008.15), len: 508 aa. Probable
conserved integral membrane transport protein, member of
major facilitator superfamily (MFS) possibly involved in
drug transport, highly similar to many efflux proteins
e.g. Q9RL22|SC5G9.04c putative transmembrane efflux
protein from Streptomyces coelicolor (489 aa), FASTA
scores: opt: 788,E(): 1.3e-38, (34.45% identity in 412 aa
overlap); Q9I428|PA1316 probable MFS transporter from
Pseudomonas aeruginosa (513 aa), FASTA scores: opt: 782,
E(): 3.1e-38,(32.75% identity in 519 aa overlap);
P39886|TCMA_STRGA tetracenomycin C resistance and export
protein from Streptomyces glaucescens (538 aa), FASTA
scores: opt: 752,E(): 1.8e-36, (31.7% identity in 511 aa
overlap); etc. Also highly similar to AAK46687|MT2395 drug
transporter from Mycobacterium tuberculosis strain CDC1551
(537 aa), FASTA scores: opt: 1396, E(): 5.6e-74, (44.45%
identity in 504 aa overlap); and
P71879|Rv2333c|MTCY3G12.01 probable conserved integral
membrane transport protein from Mycobacterium tuberculosis
strain H37Rv (537 aa), FASTA scores: opt: 1385, E():
2.5e-73, (44.25% identity in 504 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2459"
/db_xref="EnsemblGenomes-Tr:CCP45252"
/db_xref="GOA:P9WJW9"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJW9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45252.1"
/translation="MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGL
QWAVAGYSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTVAR
VIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPALGGLMVDGLG
WRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQLTLIPAVALIAYTIIEAPR
FDRQSAGFVAALLLAAGVLLWLFVRHEHRAAFPLVDLKLFAEPLYRSVLIVYFVVMSC
FFGTLMVITQHFQNVRDLSPLHAGLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCL
AAMFIGLAIFAISMDHAHPVALVGLTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGM
LNLQRSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPIARAIVVDVIVDSANPHAH
AAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGGAAVLLTGAFVLGWTRFPRTPAS
"
gene complement(2762531..2763175)
/gene="clpP2"
/locus_tag="Rv2460c"
CDS complement(2762531..2763175)
/codon_start=1
/transl_table=11
/gene="clpP2"
/locus_tag="Rv2460c"
/product="Probable ATP-dependent CLP protease proteolytic
subunit 2 ClpP2 (endopeptidase CLP 2)"
/note="Rv2460c, (MT2535, MTV008.16c), len: 214 aa.
Probable clpP2, ATP-dependent clp protease proteolytic
subunit 2,equivalent to Q9CBY4|CLP2_MYCLE ATP-dependent
CLP protease proteolytic subunit from Mycobacterium leprae
(214 aa). Also highly similar to others e.g. Q9ZH58|CLPP2
from Streptomyces coelicolor (236 aa), FASTA scores: opt:
918,E(): 2.1e-50, (66.35% identity in 214 aa overlap);
O67357|CLPP_AQUAE|AQ_1339 from Aquifex aeolicus (201
aa),FASTA scores: opt: 680, E(): 1.4e-35, (52.0% identity
in 194 aa overlap); P43867|CLPP_HAEIN from Haemophilus
influenzae (193 aa), FASTA scores: opt: 662, E():
1.8e-34,(53.35% identity in 193 aa overlap); etc. Contains
PS00381 Endopeptidase Clp serine active site. Also similar
to upstream ORF Rv2461c|MTV008.17c|clpP1 (200 aa), FASTA
score: (48.3% identity in 172 aa overlap). Belongs to
peptidase family S14, also known as ClpP family. Conserved
in M. tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2460c"
/db_xref="EnsemblGenomes-Tr:CCP45253"
/db_xref="GOA:P9WPC3"
/db_xref="InterPro:IPR001907"
/db_xref="InterPro:IPR018215"
/db_xref="InterPro:IPR023562"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR033135"
/db_xref="PDB:4U0G"
/db_xref="PDB:5DZK"
/db_xref="PDB:5E0S"
/db_xref="UniProtKB/Swiss-Prot:P9WPC3"
/inference="protein motif:PROSITE:PS00381"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45253.1"
/translation="MNSQNSQIQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFL
GVQVDDASANDIMAQLLVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQT
VCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERM
RTLMETTLARHTGKDAGVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTA"
repeat_region 2762762..2763061
/note="300 bp direct repeat copy 1"
gene complement(2763172..2763774)
/gene="clpP1"
/gene_synonym="clp"
/locus_tag="Rv2461c"
CDS complement(2763172..2763774)
/codon_start=1
/transl_table=11
/gene="clpP1"
/gene_synonym="clp"
/locus_tag="Rv2461c"
/product="Probable ATP-dependent CLP protease proteolytic
subunit 1 ClpP1 (endopeptidase CLP)"
/note="Rv2461c, (MT2536, MTV008.17c), len: 200 aa.
Probable clpP1, ATP-dependent clp protease proteolytic
subunit 1,equivalent to Q9CBY3|CLP1_MYCLE ATP-dependent
CLP protease proteolytic subunit from Mycobacterium leprae
(224 aa),FASTA scores: opt: 1226, E(): 1.3e-71, (95.0%
identity in 200 aa overlap). Also highly similar to others
e.g. Q9F315|CLPP1 from Streptomyces coelicolor (219 aa),
FASTA scores: opt: 713, E(): 9.3e-39, (61.75% identity in
183 aa overlap); P80244|CLPP_BACSU from Bacillus subtilis
(197 aa), FASTA scores: opt: 658, E(): 2.8e-35, (54%
identity in 187 aa overlap); Q9WZF9|CLPP_THEMA|TM0695 from
Thermotoga maritima (203 aa), FASTA scores: opt: 653, E():
6.1e-35,(55.25% identity in 172 aa overlap); etc. Also
similar to downstream ORF Rv2460c|MTV008.16c|clpP2 (214
aa), FASTA score: (48.3% identity in 172 aa overlap).
Belongs to peptidase family S14, also known as CLPP
family. Note that previously known as clp. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2461c"
/db_xref="EnsemblGenomes-Tr:CCP45254"
/db_xref="GOA:P9WPC5"
/db_xref="InterPro:IPR001907"
/db_xref="InterPro:IPR023562"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR033135"
/db_xref="PDB:2C8T"
/db_xref="PDB:2CBY"
/db_xref="PDB:2CE3"
/db_xref="PDB:4U0G"
/db_xref="PDB:4U0H"
/db_xref="PDB:5DZK"
/db_xref="PDB:5E0S"
/db_xref="UniProtKB/Swiss-Prot:P9WPC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45254.1"
/translation="MSQVTDMRSNSQGLSLTDSVYERLLSERIIFLGSEVNDEIANRL
CAQILLLAAEDASKDISLYINSPGGSISAGMAIYDTMVLAPCDIATYAMGMAASMGEF
LLAAGTKGKRYALPHARILMHQPLGGVTGSAADIAIQAEQFAVIKKEMFRLNAEFTGQ
PIERIEADSDRDRWFTAAEALEYGFVDHIITRAHVNGEAQ"
repeat_region 2763397..2763696
/note="300 bp direct repeat copy 2"
gene complement(2763891..2765291)
/gene="tig"
/locus_tag="Rv2462c"
CDS complement(2763891..2765291)
/codon_start=1
/transl_table=11
/gene="tig"
/locus_tag="Rv2462c"
/product="Probable trigger factor (TF) protein Tig"
/note="Rv2462c, (MTV008.18c), len: 466 aa. Probable
tig,trigger factor (TF), a chaperone protein, equivalent
to Q9CBY2|ML1481 possible molecular chaperone from
Mycobacterium leprae (469 aa), FASTA scores: opt:
2171,E(): 7.2e-113, (70.1% identity in 468 aa overlap).
Also similar to oyher trigger factors from several
organisms e.g. Q9F314|SCC80.05c from Streptomyces
coelicolor (468 aa), FASTA scores: opt: 1224, E():
1.7e-60, (41.8% identity in 469 aa overlap);
Q9K8F3|TIG_BACHD from Bacillus halodurans (431 aa), FASTA
scores: opt: 675, E(): 3.6e-30,(28.5% identity in 421 aa
overlap); P22257|TIG_ECOLI from Escherichia coli (432 aa),
FASTA scores: opt: 493, E(): 4.2e-20, (23.35% identity in
433 aa overlap); etc. Belongs to the FKBP-type PPIase
family, TIG subfamily."
/db_xref="EnsemblGenomes-Gn:Rv2462c"
/db_xref="EnsemblGenomes-Tr:CCP45255"
/db_xref="GOA:P9WG55"
/db_xref="InterPro:IPR005215"
/db_xref="InterPro:IPR008880"
/db_xref="InterPro:IPR008881"
/db_xref="InterPro:IPR027304"
/db_xref="InterPro:IPR036611"
/db_xref="InterPro:IPR037041"
/db_xref="UniProtKB/Swiss-Prot:P9WG55"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45255.1"
/translation="MKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGF
RPGKAPAKLLEARIGREAMLDQIVNDALPSRYGQAVAESDVQPLGRPNIEVTKKEYGQ
DLQFTAEVDIRPKISPPDLSALTVSVDPIEIGEDDVDAELQSLRTRFGTLTAVDRPVA
VGDVVSIDLSATVDGEDIPNAAAEGLSHEVGSGRLIAGLDDAVVGLSADESRVFTAKL
AAGEHAGQEAQVTVTVRSVKERELPEPDDEFAQLASEFDSIDELRASLSDQVRQAKRA
QQAEQIRNATIDALLEQVDVPLPESYVQAQFDSVLHSALSGLNHDEARFNELLVEQGS
SRAAFDAEARTASEKDVKRQLLLDALADELQVQVGQDDLTERLVTTSRQYGIEPQQLF
GYLQERNQLPTMFADVRRELAIRAAVEAATVTDSDGNTIDTSEFFGKRVSAGEAEEAE
PADEGAARAASDEATT"
gene complement(2765331..2765404)
/gene="proU"
tRNA complement(2765331..2765404)
/gene="proU"
/product="tRNA-Pro"
/anticodon=(pos:complement(2765368..2765370),aa:Pro,
seq:tgg)
/note="codon recognized: CCA; proU, tRNA-Pro; anticodon
tgg, length = 74"
gene 2765541..2765611
/gene="glyV"
tRNA 2765541..2765611
/gene="glyV"
/product="tRNA-Gly"
/anticodon=(pos:2765573..2765575,aa:Gly,seq:tcc)
/note="codon recognized: GGA; glyV, tRNA-Gly; anticodon
tcc, length = 71"
gene 2765655..2766839
/gene="lipP"
/locus_tag="Rv2463"
CDS 2765655..2766839
/codon_start=1
/transl_table=11
/gene="lipP"
/locus_tag="Rv2463"
/product="Probable esterase/lipase LipP"
/note="Rv2463, (MTV008.19), len: 394 aa. Probable
lipP,esterase, lipase similar to others eg O87861|ESTA
esterase a from Streptomyces chrysomallus (389 aa), FASTA
scores: opt: 964, E(): 1.9e-53, (44.35% identity in 399 aa
overlap); Q9I4S7|PA1047 probable esterase from Pseudomonas
aeruginosa (392 aa), FASTA scores: opt: 863, E():
4.6e-47,(40.05% identity in 377 aa overlap); Q53403|ESTC
esterase III from Pseudomonas fluorescens (382 aa), FASTA
scores: opt: 753, E(): 3.9e-40, (36.3% identity in 380 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2463"
/db_xref="EnsemblGenomes-Tr:CCP45256"
/db_xref="GOA:O53190"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:O53190"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45256.1"
/translation="MNQPDIKGSCASEFTKVRDAFERNFVLRNEVGAAVAVWVDGDLV
VNLWGGSADAGGTRPWQHDTLATVLSGTKALTATCVHQLVDRGELDLHAPVARYWPEF
GQAGKQAITLAMVMSHRSGAIGPRGRLGWEQVADWDFVCEQLAAAEPWWQPGAAQGYH
MTTFGFILGEVFRRVTGRTVGQYLRTEIAEPLGADVHIGLHPGEQLRCADLVDKPHIR
QLLADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNGQVSAL
GLATFYNGLAQEKLLSREHMELVRVSQGGFDTDLVLGPRVADHGWGLGYMLNQRGVNG
PNPRIFGHGGLGGSFGFVDLEHRIGYAYVMNRFDATKANADPRSVVLSNEVYAALGVN
RS"
gene complement(2766859..2767665)
/locus_tag="Rv2464c"
CDS complement(2766859..2767665)
/codon_start=1
/transl_table=11
/locus_tag="Rv2464c"
/product="Possible DNA glycosylase"
/note="Rv2464c, (MT2539, MTV008.20c), len: 268 aa.
Possible DNA glycosylase, showing some similarity to
several other DNA glycosylases e.g. Q9F308|SCC80.11c
putative DNA repair hydrolase (fragment) from Streptomyces
coelicolor (306 aa),FASTA scores: opt: 894, E(): 6.1e-51,
(51.05% identity in 282 aa overlap); O50606|MUTM|FPG_THETH
formamidopyrimidine-DNA glycosylase from Thermus aquaticus
(267 aa), FASTA scores: opt: 342, E(): 4.6e-15, (32.4%
identity in 250 aa overlap); Q9RCW5|SCM10.34c putative
formamidopyrimidine-DNA glycosylase from Streptomyces
coelicolor (287 aa), FASTA scores: opt: 321, E():
1.1e-13,(29.35% identity in 259 aa overlap); etc.
Identical to AAK46839|MT2539 formamidopyrimidine-DNA
glycosylase from Mycobacterium tuberculosis strain
CDC1551. Also similar to other Mycobacterium tuberculosis
DNA glycosylases e.g. MTCY71.37 (32.9% identity in 277 aa
overlap). Belongs to the FPG family."
/db_xref="EnsemblGenomes-Gn:Rv2464c"
/db_xref="EnsemblGenomes-Tr:CCP45257"
/db_xref="GOA:P9WNB9"
/db_xref="InterPro:IPR000214"
/db_xref="InterPro:IPR010663"
/db_xref="InterPro:IPR010979"
/db_xref="InterPro:IPR012319"
/db_xref="InterPro:IPR015886"
/db_xref="InterPro:IPR015887"
/db_xref="InterPro:IPR035937"
/db_xref="UniProtKB/Swiss-Prot:P9WNB9"
/protein_id="CCP45257.1"
/translation="MPEGHTLHRLARLHQRRFAGAPVSVSSPQGRFADSASALNGRVL
RRASAWGKHLFHHYVGGPVVHVHLGLYGTFTEWARPTDGWLPEPAGQVRMRMVGAEFG
TDLRGPTVCESIDDGEVADVVARLGPDPLRSDANPSSAWSRITKSRRPIGALLMDQTV
IAGVGNVYRNELLFRHRIDPQRPGRGIGEPEFDAAWNDLVSLMKVGLRRGKIIVVRPE
HDHGLPSYLPDRPRTYVYRRAGEPCRVCGGVIRTALLEGRNVFWCPVCQT"
gene complement(2767671..2768159)
/gene="rpiB"
/locus_tag="Rv2465c"
CDS complement(2767671..2768159)
/codon_start=1
/transl_table=11
/gene="rpiB"
/locus_tag="Rv2465c"
/product="Ribose-5-phosphate isomerase"
/note="Rv2465c, (MTV008.21c), len: 162 aa.
RpiB,Ribose-5-phosphate isomerase, proven biochemically
(see Roos et al., 2004) equivalent to AAK46840|MT2540
putative carbohydrate-phosphate isomerase from
Mycobacterium tuberculosis strain CDC1551 (159 aa).
Equivalent to Q9CBY1|ML1484 possible phosphopentose
isomerase from Mycobacterium leprae (162 aa), FASTA
scores: opt: 992, E(): 7.1e-59, (89.5% identity in 162 aa
overlap). Also highly similar or similar to several
diverse isomerases e.g. Q9L206|SC8E4.02c putative
isomerase from Streptomyces coelicolor (159 aa), FASTA
scores: opt: 661, E(): 6.1e-37,(61.45% identity in 153 aa
overlap); P47636|Y396_MYCGE|MG396 hypothetical LACA/RPIB
family protein from Mycoplasma genitalium (152 aa), FASTA
scores: opt: 357, E(): 8.2e-17, (42% identity in 150 aa
overlap); P53527|Y396_MYCPN|MPN595|MP247 hypothetical
LACA/RPIB family protein from Mycoplasma pneumoniae (152
aa), FASTA scores: opt: 340, E(): 1.1e-15, (38.6% identity
in 145 aa overlap); P26592|LACB_STAAU
galactose-6-phosphate isomerase from Staphylococcus aureus
(171 aa), FASTA scores: opt: 296, E(): 1e-12, (35.4%
identity in 158 aa overlap) and P37351|RPIB_ECOLI ribose
5-phosphate isomerase b from Escherichia coli (149 aa),
FASTA scores: opt: 262, E(): 1.6e-10, (32.2% identity in
146 aa overlap); etc. Could belong to the LACA/RPIB
family."
/db_xref="EnsemblGenomes-Gn:Rv2465c"
/db_xref="EnsemblGenomes-Tr:CCP45258"
/db_xref="GOA:P9WKD7"
/db_xref="InterPro:IPR003500"
/db_xref="InterPro:IPR011860"
/db_xref="InterPro:IPR036569"
/db_xref="PDB:1USL"
/db_xref="PDB:2BES"
/db_xref="PDB:2BET"
/db_xref="PDB:2VVO"
/db_xref="PDB:2VVP"
/db_xref="PDB:2VVQ"
/db_xref="UniProtKB/Swiss-Prot:P9WKD7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45258.1"
/translation="MSGMRVYLGADHAGYELKQRIIEHLKQTGHEPIDCGALRYDADD
DYPAFCIAAATRTVADPGSLGIVLGGSGNGEQIAANKVPGARCALAWSVQTAALAREH
NNAQLIGIGGRMHTVAEALAIVDAFVTTPWSKAQRHQRRIDILAEYERTHEAPPVPGA
PA"
gene complement(2768261..2768884)
/locus_tag="Rv2466c"
CDS complement(2768261..2768884)
/codon_start=1
/transl_table=11
/locus_tag="Rv2466c"
/product="Conserved protein"
/note="Rv2466c, (MTV008.22c), len: 207 aa. Conserved
protein (see citation below), equivalent to Q9CBY0|ML1485
hypothetical protein from Mycobacterium leprae (207
aa),FASTA scores: opt: 1154, E(): 1.1e-67, (80.6% identity
in 206 aa overlap). Also highly similar to
Q9L201|SC8E4A.04c hypothetical protein from Streptomyces
coelicolor (216 aa),FASTA scores: opt: 789, E(): 4.6e-44,
(57.9% identity in 213 aa overlap). Also similar to
AAK46628|MT2344 hypothetical protein from Mycobacterium
tuberculosis strain CDC1551 (230 aa), FASTA scores: opt:
324, E(): 6.1e-14,(30.4% identity in 194 aa overlap).
Contains PS00195 Glutaredoxin active site."
/db_xref="EnsemblGenomes-Gn:Rv2466c"
/db_xref="EnsemblGenomes-Tr:CCP45259"
/db_xref="GOA:O53193"
/db_xref="InterPro:IPR001853"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:4NXI"
/db_xref="PDB:4ZIL"
/db_xref="PDB:5XUR"
/db_xref="UniProtKB/Swiss-Prot:O53193"
/inference="protein motif:PROSITE:PS00195"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45259.1"
/translation="MLEKAPQKSVADFWFDPLCPWCWITSRWILEVAKVRDIEVNFHV
MSLAILNENRDDLPEQYREGMARAWGPVRVAIAAEQAHGAKVLDPLYTAMGNRIHNQG
NHELDEVITQSLADAGLPAELAKAATSDAYDNALRKSHHAGMDAVGEDVGTPTIHVNG
VAFFGPVLSKIPRGEEAGKLWDASVTFASYPHFFELKRTRTEPPQFD"
gene 2768986..2771571
/gene="pepN"
/gene_synonym="pepD"
/locus_tag="Rv2467"
CDS 2768986..2771571
/codon_start=1
/transl_table=11
/gene="pepN"
/gene_synonym="pepD"
/locus_tag="Rv2467"
/product="Probable aminopeptidase N PepN (Lysyl
aminopeptidase) (LYS-AP) (alanine aminopeptidase)"
/note="Rv2467, (MTV008.23), len: 861 aa. Probable
pepN,aminopeptidase N, equivalent to Q9CBX9|ML1486
probable aminopeptidase from Mycobacterium leprae (862
aa), FASTA scores: opt: 4751,E(): 0, (83.3% identity in
862 aa overlap). Also highly similar to others e.g.
Q11010|AMPN_STRLI|PEPN from Streptomyces lividans (857
aa),FASTA scores: opt: 2839, E(): 1.8e-170, (53.25%
identity in 864 aa overlap); Q9L1Z2|PEPN from Streptomyces
coelicolor (857 aa), FASTA scores: opt: 2834, E():
3.8e-170, (53.1% identity in 864 aa overlap);
P37896|AMPN_LACDL|PEPN from Lactobacillus delbrueckii
(subsp. lactis) (842 aa), FASTA scores: opt: 719, E():
2.4e-37, (31.65% identity in 439 aa overlap); etc.
Contains PS00142 Neutral zinc metallopeptidases,
zinc-binding region signature. Belongs to peptidase family
M1 (zinc metalloprotease), also known as the PEPN
subfamily. Note that previously known as pepD. Conserved
in M. tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2467"
/db_xref="EnsemblGenomes-Tr:CCP45260"
/db_xref="GOA:L7N655"
/db_xref="InterPro:IPR001930"
/db_xref="InterPro:IPR012778"
/db_xref="InterPro:IPR014782"
/db_xref="InterPro:IPR024571"
/db_xref="InterPro:IPR042097"
/db_xref="UniProtKB/TrEMBL:L7N655"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45260.1"
/translation="MALPNLTRDQAVERAALITVDSYQIILDVTDGNGAPGERTFRST
TTVVFDALPGADTVIDISAHTVRRASLNDQDLDVSGYDEAAGIPLRGLAQRNVVVVDA
DCHYSNTGEGLHRFVDPVDGETYLYSQFETADAKRMFACFDQPDLKATFDVRVTAPAH
WKVISNGAPLAAANGVHTFATTPRMSTYLVALIAGPYAAWTDTYIDDHGEIPLGIYCR
ASLAEYMDAERLFTQTKQGFGFYHKHFGLPYAFGKYDQLFVPEFNAGAMENAGAVTFL
EDYVFRSKVTRASYERRAETVLHEMAHMWFGDLVTMTWWDDLWLNESFATFASVLCQS
EATEFTEAWTTFATVEKSWAYRQDQLPSTHPIAADIPDLAAVEVNFDGITYAKGASVL
KQLVAYVGLERFLAGLRDYFRTHAFGNASFDDLLAALEKASGRDLSNWGEQWLKTTGL
NTLRPDFEVDAEGRFTRFAVTQSGAAPGAGETRVHRLAVGIYDDDGSKSSGKLVRVHR
EELDVSGPITNVPALVGVSRGKLILVNDDDLTYCSLRLDERSLQTALDRIADIAEPLP
RTLVWSAAWEMTREAELRARDFVSLVSGGVHAETEVGVAQRLLLQAQTALGCYAEPGW
ARERGWPQFADRLLELAREAEPGSDHQLAYINSLCSSVLSPRHVQTLGALLEGEPAAC
GLAGLAVDTDLRWRIVTALATAGAIDADGPETPRIDAEVQRDPTAAGKRHAAQARAAR
PQFVVKDEAFTTVVEDDTLANATGRAMIAGIAAPGQGELLKPFARRYFQAIPGVWARR
SSEVAQSVVIGLYPHWDISEQGITAAEEFLSDPEVPPALRRLVLEGQAAVQRSLRARN
FDADG"
gene complement(2771644..2772147)
/locus_tag="Rv2468c"
CDS complement(2771644..2772147)
/codon_start=1
/transl_table=11
/locus_tag="Rv2468c"
/product="Conserved protein"
/note="Rv2468c, (MTV008.24c), len: 167 aa. Conserved
protein, highly similar to Mycobacterium leprae
hypothetical proteins Q9CC58|ML1255 (163 aa), FASTA
scores: opt: 859, E(): 1.6e-49, (81.2% identity in 165 aa
overlap) and Q9X7B5|MLCB1610.16 (169 aa), FASTA scores:
opt: 859,E(): 1.6e-49, (81.2% identity in 165 aa overlap).
Also weak similarity with Q9X8D7|SCE39.14c putative
GntR-family regulator from Streptomyces coelicolor (243
aa), FASTA scores: opt: 116, E(): 1.3, (30.1% identity in
156 aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2468c"
/db_xref="EnsemblGenomes-Tr:CCP45261"
/db_xref="GOA:P9WLA7"
/db_xref="InterPro:IPR033437"
/db_xref="UniProtKB/Swiss-Prot:P9WLA7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45261.1"
/translation="MTHRSSRLEVGPVARGDVATIEHAELPPGWVLTTSGRISGVTEP
GELSVHYPFPIADLVALDDALTYSSRACQVRFAIYLGDLGRDTAARAREILGKVPTPD
NAVLLAVSPNQCAIEVVYGSQVRGRGAESAAPLGVAAASSAFEQGELVDGLISAIRVL
SAGIAPG"
gene complement(2772098..2772331)
/locus_tag="Rv2468A"
CDS complement(2772098..2772331)
/codon_start=1
/transl_table=11
/locus_tag="Rv2468A"
/product="Conserved protein"
/note="Rv2468A, len: 77 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv2468A"
/db_xref="EnsemblGenomes-Tr:CCP45262"
/db_xref="GOA:I6YDH3"
/db_xref="UniProtKB/TrEMBL:I6YDH3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45262.1"
/translation="MEIHLFFVGIPLLLVVVLSVLIWSRKGPHPATYKLSEPWTHPPI
LWAATDEVVGSAHGGHGHDASEFTVGGGASGTW"
gene complement(2772367..2773035)
/locus_tag="Rv2469c"
CDS complement(2772367..2773035)
/codon_start=1
/transl_table=11
/locus_tag="Rv2469c"
/product="Conserved hypothetical protein"
/note="Rv2469c, (MTV008.25c), len: 222 aa. Conserved
hypothetical protein, highly similar to other hypothetical
proteins e.g. Q9X7B4|MLCB1610.15|ML1254 from Mycobacterium
leprae (215 aa), FASTA scores: opt: 1183, E():
3.3e-70,(77.9% identity in 222 aa overlap);
Q9L1Y0|SC8E4A.25c from Streptomyces coelicolor (178 aa),
FASTA scores: opt: 589,E(): 1.7e-31, (53.4% identity in
161 aa overlap) (N-terminal region is shorter 50 aa
approximately); Q9RRS6|DR2409 conserved hypothetical
protein from Deinococcus radiodurans (186 aa), FASTA
scores: opt: 440,E(): 9.6e-22, (42.25% identity in 168 aa
overlap) (N-terminal region is shorter 30 aa
approximately); etc."
/db_xref="EnsemblGenomes-Gn:Rv2469c"
/db_xref="EnsemblGenomes-Tr:CCP45263"
/db_xref="GOA:O53196"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR029471"
/db_xref="UniProtKB/TrEMBL:O53196"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45263.1"
/translation="MAHGKKRRGHRSSGVAAGVTGPASCLHSVHSHRLASGVETHPPN
RHESASIWNRRRVLLLNSTYEPLTALSMRRAIVMVICGKADVVHEDPSGPVIHSATRS
ILVPSVIQLRSYVRVPYRARVPMTRAALMHRDRFCCAYCGGKADTVDHVVPRSRGGAH
SWENCVACCSPCNHRKGDRLLTELGWALRRAPLPPTGPHWRLLSAVKELDPSWARYLG
EGAA"
gene 2773178..2773564
/gene="glbO"
/locus_tag="Rv2470"
CDS 2773178..2773564
/codon_start=1
/transl_table=11
/gene="glbO"
/locus_tag="Rv2470"
/product="Globin (oxygen-binding protein) GlbO"
/note="Rv2470, (MTV008.26), len: 128 aa. glbO, globin-like
protein, highly similar to Q9CC59|GLBO|ML1253
hemoglobin-like (oxygen carrier) from Mycobacterium leprae
(128 aa), FASTA scores: opt: 767, E(): 4e-47, (88.1%
identity in 126 aa overlap); Q9X7B3|MLCB1610.14c putative
globin from Mycobacterium leprae (131 aa);
Q9L250|SC6D10.14 putative globin from Streptomyces
coelicolor (137 aa),FASTA scores: opt: 466, E(): 5.7e-26,
(53.6% identity in 125 aa overlap). Also similar to O31607
YJBI protein from Bacillus subtilis (132 aa), FASTA
scores: opt: 294, E(): 6.6e-14; (39.85% identity in 128 aa
overlap). Could belong to protozoan/cyanobacterial globin
family protein."
/db_xref="EnsemblGenomes-Gn:Rv2470"
/db_xref="EnsemblGenomes-Tr:CCP45264"
/db_xref="GOA:P9WN23"
/db_xref="InterPro:IPR001486"
/db_xref="InterPro:IPR009050"
/db_xref="InterPro:IPR012292"
/db_xref="InterPro:IPR019795"
/db_xref="PDB:1NGK"
/db_xref="PDB:2QRW"
/db_xref="UniProtKB/Swiss-Prot:P9WN23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45264.1"
/translation="MPKSFYDAVGGAKTFDAIVSRFYAQVAEDEVLRRVYPEDDLAGA
EERLRMFLEQYWGGPRTYSEQRGHPRLRMRHAPFRISLIERDAWLRCMHTAVASIDSE
TLDDEHRRELLDYLEMAAHSLVNSPF"
gene 2773564..2775204
/gene="aglA"
/locus_tag="Rv2471"
CDS 2773564..2775204
/codon_start=1
/transl_table=11
/gene="aglA"
/locus_tag="Rv2471"
/product="Probable alpha-glucosidase AglA (maltase)
(glucoinvertase) (glucosidosucrase) (maltase-glucoamylase)
(lysosomal alpha-glucosidase) (acid maltase)"
/note="Rv2471, (MTV008.27), len: 546 aa. Probable
aglA,maltase (alpha-glucosidase), highly similar or
similar to several e.g. Q60027|AGLA from Thermomonospora
curvata (544 aa), FASTA scores: opt: 2071, E(): 4e-116,
(57.7% identity in 525 aa overlap); Q9KZE3|AGLAE from
Streptomyces coelicolor (534 aa), FASTA scores: opt: 1475,
E(): 1.5e-80,(50.1% identity in 537 aa overlap);
O86874|AGLA from Streptomyces lividans (534 aa), FASTA
scores: opt: 1473,E(): 2e-80, (50.1% identity in 537 aa
overlap); etc. Seems to belong to family 13 of glycosyl
hydrolases, also known as the alpha-amylase family."
/db_xref="EnsemblGenomes-Gn:Rv2471"
/db_xref="EnsemblGenomes-Tr:CCP45265"
/db_xref="GOA:O53198"
/db_xref="InterPro:IPR006047"
/db_xref="InterPro:IPR017853"
/db_xref="UniProtKB/TrEMBL:O53198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45265.1"
/translation="MDQHQRPDPMGPGSPRASARRPEPDPMGEPWWSRAVFYQVYPRS
FADSNGDGVGDLDGLASRLDHLQQLGVDAIWINPVTVSPMADHGYDVADPRDIDPLFG
GMPAFERLVAAAHRQGIKVTMDVVPNHTSSAHPWFQAALADLPGSPARDRYFFRDGRG
PDGSLPPNNWESVFGGPAWTRVREPDGNPGQWYLHLFDTEQPDLNWDNPEILDDFEKT
LRFWLDRGVDGFRIDVAHGMAKPPGLPDSPDLGIEVLHHRDDDPRFNHPNVHAIHRDI
RTVIDEYPGAVTVGEVWVHDNARWAEYLRPDELHLGFNFRLARTEFDAAEIRDAVANS
LAAAALQNATPTWTLANHDVGREVSRYGGGEIGLRRAKAMAVVMLALPGVVFLYNGQE
LGLPDVDLPDEVLQDPTWERSGRTERGRDGCRVPIPWSGNIPPFGFSTCPDTWLPMPP
EWAALTAEKQRADAGSTLSFFRLALRLRRERNEFDGDVDWLAAPDDALIFRRHGGGLV
CALNAAERPLALPAGEPILASAPLTDATLPPNAAAWLV"
gene 2775272..2775565
/locus_tag="Rv2472"
CDS 2775272..2775565
/codon_start=1
/transl_table=11
/locus_tag="Rv2472"
/product="Conserved hypothetical protein"
/note="Rv2472, (MTV008.28), len: 97 aa. Conserved
hypothetical protein, showing some similarity to
O53451|Rv1103c|MTV017.56c from Mycobacterium tuberculosis
strain H37Rv (106 aa), FASTA scores: opt: 135, E():
0.026,(45.85% identity in 72 aa overlap); and
AAK45393|MT1135 hypothetical 11.4 KDA protein from
Mycobacterium tuberculosis strain CDC1551 (78 aa) FASTA
scores: opt: 139,E(): 0.011, (45.35% identity in 75 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2472"
/db_xref="EnsemblGenomes-Tr:CCP45266"
/db_xref="UniProtKB/TrEMBL:O53199"
/protein_id="CCP45266.1"
/translation="MMMRIAVRLPGEVITFVDSEVSQIRIPSRRAAVVLRASNASDAA
ILTATEPNHHLDALAGQAAKLAPTSIDAAHPARPARRDPCLYPRTGQALPRTG"
gene 2775568..2776284
/locus_tag="Rv2473"
CDS 2775568..2776284
/codon_start=1
/transl_table=11
/locus_tag="Rv2473"
/product="Possible alanine and proline rich membrane
protein"
/note="Rv2473, (MTV008.29), len: 238 aa. Possible
pro-,ala-rich membrane protein, with possible
transmembrane domain around aa 81-104."
/db_xref="EnsemblGenomes-Gn:Rv2473"
/db_xref="EnsemblGenomes-Tr:CCP45267"
/db_xref="GOA:O53200"
/db_xref="UniProtKB/TrEMBL:O53200"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45267.1"
/translation="MAPTSSSVASELLMPWPSAAASGVVGWRTTATASQRYHRPMSDT
PFAEPYPEQRPPWGVPPPGWDGSSRPAPSTTPRSPGRWSLVAALALAVVSLGVGIVGW
FHRQPHDKPSPAPSAPTFTSQQISDAKENVCAAHRIVRQAAVLNTNQANPVPGDPTGD
LAVAANARLALYSGGDYLLRRLTAEPATPAELRDAVRSLANALQELAVNYLAGAPDSV
VTPLRLALERDTRAVDPLCV"
gene complement(2776316..2776969)
/locus_tag="Rv2474c"
CDS complement(2776316..2776969)
/codon_start=1
/transl_table=11
/locus_tag="Rv2474c"
/product="Conserved hypothetical protein"
/note="Rv2474c, (MTV008.30c), len: 217 aa. Hypothetical
protein. Shows weak similarity with Q9L246|SC6D10.18c
hypothetical 24.9 KDA protein from Streptomyces coelicolor
(238 aa), FASTA scores: opt: 111, E(): 5.6, (30% identity
in 233 aa overlap), blastp scores: Score= 135, E=
3.5e-07,P= 3.5e-07, Identities= 55/182 (30%)."
/db_xref="EnsemblGenomes-Gn:Rv2474c"
/db_xref="EnsemblGenomes-Tr:CCP45268"
/db_xref="InterPro:IPR016601"
/db_xref="UniProtKB/TrEMBL:I6X4D6"
/protein_id="CCP45268.1"
/translation="MVERGLWLPDPAHRADLATFVDHALRLDDAAVIRIRARSTGLLS
AWVATGFDVLASRVVAGKVRPDDLSVAARSLAHGLATTDASGYVDPGYSMDSAWRGGL
PPESGFTYLDDVPARVMLDLAHRGARLAKEHGSSAGPPVSLLDQEVIQVSSADVVVGL
PMRCVFALTAMGFLPQSAETISADELIRVRISPAWLRLDARFGSVYRHRGHAALVLR"
gene complement(2776975..2777391)
/locus_tag="Rv2475c"
CDS complement(2776975..2777391)
/codon_start=1
/transl_table=11
/locus_tag="Rv2475c"
/product="Conserved protein"
/note="Rv2475c, (MTV008.31c), len: 138 aa. Conserved
protein, showing similarity with Q9L245|SC6D10.19c
hypothetical 16.2 KDA protein from Streptomyces coelicolor
(136 aa), FASTA scores: opt: 236, E(): 1.9e-09, (34.1%
identity in 126 aa overlap). Also some similarity with
AAK44393|Z97050|MTCI28_3 conserved hypothetical protein
from Mycobacterium tuberculosis cosmid I (151 aa), FASTA
scores: opt: 147, E(): 0.00025, (29.2% identity in 120 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2475c"
/db_xref="EnsemblGenomes-Tr:CCP45269"
/db_xref="GOA:I6Y9E8"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:I6Y9E8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45269.1"
/translation="MSVGFVTPVGVRWSDIDMYQHVNHATMVTILEEARVPFLKDAFG
ADITSTGLLIADVRVTYKGQLRLSDSPLQVTIWTKRLRAVDFTLGYEVRSVNAEPDSR
PAVIAESQLAAFHIEEQRLVRLSPHHREYLQRWFRG"
gene complement(2777388..2782262)
/gene="gdh"
/locus_tag="Rv2476c"
CDS complement(2777388..2782262)
/codon_start=1
/transl_table=11
/gene="gdh"
/locus_tag="Rv2476c"
/product="Probable NAD-dependent glutamate dehydrogenase
Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)"
/note="Rv2476c, (MTV008.32c), len: 1624 aa. Probable
gdh,glutamate dehydrogenase. Highly similar to
Q9X7B2|MLCB1610.10|ML1249 hypothetical 177.9 KDA protein
from Mycobacterium leprae (1622 aa), FASTA scores: opt:
8630,E(): 0, (81.45% identity in 1634 aa overlap). But
highly similar to Q9F0J1|GDH NAD-glutamate dehydrogenase
from Streptomyces clavuligerus (1651 aa), FASTA scores:
opt: 3833, E(): 0, (45.8% identity in 1600 aa overlap);
(see Minambres et al., 2000). Also similar with others
e.g. AAG53963|PA3068|GDHB hypothetical (NAD(+)-dependent
glutamate dehydrogenase from Pseudomonas aeruginosa (1620
aa), FASTA scores: opt: 2214, E(): 1e-124, (40.1% identity
in 1561 aa overlap) (see Lu & Abdelal 2001); and
Q9Y8G5|GDHB NAD-specific glutamate dehydrogenase from
Agaricus bisporus (1029 aa), FASTA scores: opt: 194, E():
0.00099, (22.7% identity in 647 aa overlap) (see Kersten
et al., 1999); etc. Contains possible Helix-turn-helix
motif at aa 1568 to 1589 (score 1098, +2.93 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2476c"
/db_xref="EnsemblGenomes-Tr:CCP45270"
/db_xref="GOA:O53203"
/db_xref="InterPro:IPR007780"
/db_xref="InterPro:IPR028971"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:O53203"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45270.1"
/translation="MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSYRGPRDDSSE
ATKAAEASWLPASLLTPAMLGAHYRLGRHRAAGESCVAVYRADDPAGFGPALQVVAEH
GGMLMDSVTVLLHRLGIAYAAILTPVFDVHRSPTGELLRIEPKAEGTSPHLGEAWMHV
ALSPAVDHKGLAEVERLLPKVLADVQRVATDATALIATLSELAGEVESNAGGRFSAPD
RQDVGELLRWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKL
LVLAQARVGSYLRYGAYPYAIAVREYVDGSVVEHRFVGLFSVAAMNADVLEIPTISRR
VREALAMAESDPSHPGQLLLDVIQTVPRPELFTLSAQRLLTMARAVVDLGSQRQALLF
LRADRLQYFVSCLVYMPRDRYTTAVRMQFEDILVREFGGTRLEFTARVSESPWALMHF
MVRLPEVGVAGEGAAAPPVDVSEANRIRIQGLLTEAARTWADRLIGAAAAAGSVGQAD
AMHYAAAFSEAYKQAVTPADAIGDIAVITELTDDSVKLVFSERDEQGVAQLTWFLGGR
TASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIPLAPTVAERAA
TAHRFAEAVTAIWHGRVEIDRFNELVMRAGLTWQQVVLLRAYAKYLRQAGFPYSQSYI
ESVLNEHPATVRSLVDLFEALFVPVPSGSASNRDAQAAAAAVAADIDALVSLDTDRIL
RAFASLVQATLRTNYFVTRQGSARCRDVLALKLNAQLIDELPLPRPRYEIFVYSPRVE
GVHLRFGPVARGGLRWSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLP
TGDPAADRDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAYLVV
AADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAWEAVKRHFRE
IGIDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDHRHIFLDPNPDAAVSWAE
RRRMFELPRSSWSDYDRSLISEGGGVYSREQKAIPLSAQVRAVLGIDGSVDGGAAEMA
PPNLIRAILRAPVDLLFNGGIGTYIKAESESDADVGDRANDPVRVNANQVRAKVIGEG
GNLGVTALGRVEFDLSGGRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVKADER
TQLLESMTDEVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRELE
ALPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFASRLPRYFP
TALRERFTPEIRSHQLRREIVTTMLINDLVDTAGITYAFRIAEDVGVTPIDAVRTYVA
TDAIFGVGHIWRRIRAANLPIALSDRLTLDTRRLIDRAGRWLLNYRPQPLAVGAEINR
FAAMVKALTPRMSEWLRGDDKAIVEKTAAEFASQGVPEDLAYRVSTGLYRYSLLDIID
IADIADIDAAEVADTYFALMDRLGTDGLLTAVSQLPRHDRWHSLARLAIRDDIYGALR
SLCFDVLAVGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAARQ
IRRMTRTSGRGISG"
gene complement(2782366..2784042)
/locus_tag="Rv2477c"
CDS complement(2782366..2784042)
/codon_start=1
/transl_table=11
/locus_tag="Rv2477c"
/product="Probable macrolide-transport ATP-binding protein
ABC transporter"
/note="Rv2477c, (MTV008.33c), len: 558 aa. Probable ATP
binding protein ABC-transporter (see citation
below),probably involved in macrolide transport,
equivalent to Q9X7B1|MLCB1610.09|ML1248 putative ABC
transporter ATP-binding protein from Mycobacterium leprae
(556 aa) FASTA scores: opt: 3448, E(): 3.8e-176, (92.3%
identity in 557 aa overlap). Also highly similar to many
ATP binding proteins e.g. Q9L244|SC6D10.20c putative ABC
transporter ATP-binding protein from Streptomyces
coelicolor (547 aa),FASTA scores: opt: 2937, E():
5.6e-149, (79.5% identity in 551 aa overlap);
AAK24119|CC2148 ABC transporter ATP-binding protein from
Caulobacter crescentus (555 aa),FASTA scores: opt: 2175,
E(): 1.9e-108, (59.4% identity in 557 aa overlap); Q9HVJ1
probable ATP-binding component of ABC transporter from
Pseudomonas aeruginosa (554 aa), FASTA scores: opt: 2054,
E(): 5.1e-102, (56.9% identity in 559 aa overlap); etc.
Contains 2 x PS00017 ATP/GTP-binding site motif A
(P-loop), 2 x PS00211 ABC transporters family signature,
and probable coiled-coil from aa 273 to 311. Belongs to
the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv2477c"
/db_xref="EnsemblGenomes-Tr:CCP45271"
/db_xref="GOA:P9WQK3"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR022374"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR032781"
/db_xref="UniProtKB/Swiss-Prot:P9WQK3"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45271.1"
/translation="MAEFIYTMKKVRKAHGDKVILDDVTLSFYPGAKIGVVGPNGAGK
SSVLRIMAGLDKPNNGDAFLATGATVGILQQEPPLNEDKTVRGNVEEGMGDIKIKLDR
FNEVAELMATDYTDELMEEMGRLQEELDHADAWDLDAQLEQAMDALRCPPADEPVTNL
SGGERRRVALCKLLLSKPDLLLLDEPTNHLDAESVQWLEQHLASYPGAILAVTHDRYF
LDNVAEWILELDRGRAYPYEGNYSTYLEKKAERLAVQGRKDAKLQKRLTEELAWVRSG
AKARQAKSKARLQRYEEMAAEAEKTRKLDFEEIQIPVGPRLGNVVVEVDHLDKGYDGR
ALIKDLSFSLPRNGIVGVIGPNGVGKTTLFKTIVGLETPDSGSVKVGETVKLSYVDQA
RAGIDPRKTVWEVVSDGLDYIQVGQTEVPSRAYVSAFGFKGPDQQKPAGVLSGGERNR
LNLALTLKQGGNLILLDEPTNDLDVETLGSLENALLNFPGCAVVISHDRWFLDRTCTH
ILAWEGDDDNEAKWFWFEGNFGAYEENKVERLGVDAARPHRVTHRKLTRG"
gene complement(2784123..2784608)
/locus_tag="Rv2478c"
CDS complement(2784123..2784608)
/codon_start=1
/transl_table=11
/locus_tag="Rv2478c"
/product="Conserved hypothetical protein"
/note="Rv2478c, (MTV008.34c), len: 161 aa. Conserved
hypothetical protein, with weak similarity with many
single-strand binding proteins e.g. Q9X8U3|SCH24.29
putative single-strand binding protein from Streptomyces
coelicolor (199 aa), FASTA scores: opt: 246, E():
4.5e-08,(31.5% identity in 162 aa overlap);
P46390|SSB_MYCLE|ML2684|MLCB1913.20c single-strand binding
protein (SSB) (helix-destabilizing protein) from
Mycobacterium leprae (168 aa), FASTA scores: opt: 239,
E(): 1e-07, (30.8% identity in 146 aa overlap);
P18310|SSBF_ECOLI single-strand binding protein from
Escherichia coli (178 aa), FASTA scores: opt: 116, E():
2.9, (25.7% identity in 140 aa overlap); etc. Also
similarity with Rv0054|P71711|MTCY21D4.17|SSB_MYCTU
probable single-strand binding protein from M.
tuberculosis (164 aa), FASTA scores: opt: 234, E(): 2e-07,
(31.75% identity in 148 aa overlap). N-terminus shorter 8
aa from AAK46855|MT2553 single-strand DNA binding protein
from Mycobacterium tuberculosis strain CDC1551."
/db_xref="EnsemblGenomes-Gn:Rv2478c"
/db_xref="EnsemblGenomes-Tr:CCP45272"
/db_xref="GOA:O53205"
/db_xref="InterPro:IPR000424"
/db_xref="InterPro:IPR011344"
/db_xref="InterPro:IPR012340"
/db_xref="UniProtKB/TrEMBL:O53205"
/protein_id="CCP45272.1"
/translation="MVGHIVNDLQRRKVGDQEVVKFRVASNSRRRTSDGGWEPGNSLF
ITVNCWGRLVTGVGAALGKGAPVIVVGHVYTSEYEDRDGIRRSSLEMRATSVGPDLSR
VIVRIEKPAYTGPSAGDLPAATGTGAAGAADAPASAADSVSDVVVDDAITGHNPLPIS
A"
mobile_element complement(2784614..2785970)
/mobile_element_type="insertion sequence:IS6110-9"
/note="IS6110-9, len: 1357 nt. Insertion sequence IS6110."
repeat_region 2784614..2784642
/note="29 bp Inverted repeat at the left end of
IS6110,GTGAACCGCCCCGGTGAGTCCGGAGACTC"
gene complement(2784657..>2785643)
/locus_tag="Rv2479c"
CDS complement(2784657..>2785643)
/codon_start=1
/transl_table=11
/locus_tag="Rv2479c"
/product="Probable transposase"
/note="Rv2479c, (MTV008.35c), len: 328 aa. Probable
transposase for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv2480c and Rv2479c, the
sequence UUUUAAAG (directly upstream of Rv2479c) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (- 18
aa)."
/db_xref="EnsemblGenomes-Gn:Rv2479c"
/db_xref="EnsemblGenomes-Tr:CCP45273"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP45273.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
gene complement(2785592..2785918)
/locus_tag="Rv2480c"
CDS complement(2785592..2785918)
/codon_start=1
/transl_table=11
/locus_tag="Rv2480c"
/product="Possible transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv2480c, (MTV008.36c), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv2480c and
Rv2479c, the sequence UUUUAAAG (directly upstream of
Rv2479c) maybe responsible for such a frameshifting event
(see McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv2480c"
/db_xref="EnsemblGenomes-Tr:CCP45274"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP45274.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
repeat_region complement(2785942..2785970)
/note="29 bp Inverted repeat at the right end of
IS6110,GTGAACCGCCCCGGCATGTCCGGAGACTC"
gene complement(2786575..2786898)
/locus_tag="Rv2481c"
CDS complement(2786575..2786898)
/codon_start=1
/transl_table=11
/locus_tag="Rv2481c"
/product="Hypothetical protein"
/note="Rv2481c, (MTV008.37c), len: 107 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2481c"
/db_xref="EnsemblGenomes-Tr:CCP45275"
/db_xref="UniProtKB/TrEMBL:O53206"
/protein_id="CCP45275.1"
/translation="MALRRRHEPDGWPFSQRSEKPNAVRHAVRCSAVSAAASTANGTP
VNWVSGRVTRAMGVHRQTRGGVASVHADSLRGAVLVHGQLRNSIPISANVPASGANTK
SSIAH"
gene complement(2786914..2789283)
/gene="plsB2"
/locus_tag="Rv2482c"
CDS complement(2786914..2789283)
/codon_start=1
/transl_table=11
/gene="plsB2"
/locus_tag="Rv2482c"
/product="Probable glycerol-3-phosphate acyltransferase
PlsB2 (GPAT)"
/note="Rv2482c, (MT2555, MTV008.38c), len: 789 aa.
Probable plsB2, glycerol-3-phosphate acyltransferase,
highly similar to Q9X7B0|PLSB_MYCLE probable
glycerol-3-phosphate acyltransferase from Mycobacterium
leprae (775 aa), FASTA scores: opt: 4210, E(): 0, (80.7%
identity in 783 aa overlap). Also similar to others e.g.
P00482|PLSB_ECOLI from Escherichia coli (806 aa), FASTA
scores: opt: 521,E(): 3e-24, (24.35 identity in 612 aa
overlap); Q9CLN7|PLSB_PASMU from Pasteurella multocida
(809 aa),FASTA scores: opt: 529, E(): 9.7e-25, (27.05%
identity in 540 aa overlap); Q9KVP8|PLSB_VIBCH from Vibrio
cholerae (811 aa), FASTA scores: opt: 510, E(): 1.4e-23,
(26.0% identity in 639 aa overlap); etc. Also highly
similar to Q10775|PLSB1|Rv1551|MTCY48.14c from M.
tuberculosis (621 aa), FASTA scores: opt: 1013, E():
1.5e-54, (34.65% identity in 586 aa overlap). Belongs to
the GPAT/DAPAT family."
/db_xref="EnsemblGenomes-Gn:Rv2482c"
/db_xref="EnsemblGenomes-Tr:CCP45276"
/db_xref="GOA:P9WI61"
/db_xref="InterPro:IPR002123"
/db_xref="InterPro:IPR022284"
/db_xref="InterPro:IPR028354"
/db_xref="InterPro:IPR041728"
/db_xref="UniProtKB/Swiss-Prot:P9WI61"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45276.1"
/translation="MTKPAADASAVLTAEDTLVLASTATPVEMELIMGWLGQQRARHP
DSKFDILKLPPRNAPPAALTALVEQLEPGFASSPQSGEDRSIVPVRVIWLPPADRSRA
GKVAALLPGRDPYHPSQRQQRRILRTDPRRARVVAGESAKVSELRQQWRDTTVAEHKR
DFAQFVSRRALLALARAEYRILGPQYKSPRLVKPEMLASARFRAGLDRIPGATVEDAG
KMLDELSTGWSQVSVDLVSVLGRLASRGFDPEFDYDEYQVAAMRAALEAHPAVLLFSH
RSYIDGVVVPVAMQDNRLPPVHMFGGINLSFGLMGPLMRRSGMIFIRRNIGNDPLYKY
VLKEYVGYVVEKRFNLSWSIEGTRSRTGKMLPPKLGLMSYVADAYLDGRSDDILLQGV
SICFDQLHEITEYAAYARGAEKTPEGLRWLYNFIKAQGERNFGKIYVRFPEAVSMRQY
LGAPHGELTQDPAAKRLALQKMSFEVAWRILQATPVTATGLVSALLLTTRGTALTLDQ
LHHTLQDSLDYLERKQSPVSTSALRLRSREGVRAAADALSNGHPVTRVDSGREPVWYI
APDDEHAAAFYRNSVIHAFLETSIVELALAHAKHAEGDRVAAFWAQAMRLRDLLKFDF
YFADSTAFRANIAQEMAWHQDWEDHLGVGGNEIDAMLYAKRPLMSDAMLRVFFEAYEI
VADVLRDAPPDIGPEELTELALGLGRQFVAQGRVRSSEPVSTLLFATARQVAVDQELI
APAADLAERRVAFRRELRNILRDFDYVEQIARNQFVACEFKARQGRDRI"
gene complement(2789280..2791022)
/gene="plsC"
/locus_tag="Rv2483c"
CDS complement(2789280..2791022)
/codon_start=1
/transl_table=11
/gene="plsC"
/locus_tag="Rv2483c"
/product="Possible transmembrane phospholipid biosynthesis
bifunctional enzyme PlsC: putative L-3-phosphoserine
phosphatase (O-phosphoserine phosphohydrolase) (PSP)
(pspase) + 1-acyl-SN-glycerol-3-phosphate acyltransferase
(1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid
acyltransferase) (LPAAT)"
/note="Rv2483c, (MTV008.39c), len: 580 aa. Possible plsC,
a transmembrane phospholipid biosynthesis bifunctional
enzyme, including L-3-phosphoserine phosphatase and
1-acyl-Sn-glycerol-3-phosphate acyltransferase ,
equivalent to Q9X7A9|PLSC|ML1245 putative acyltransferase
from Mycobacterium leprae (579 aa), FASTA scores: opt:
2835,E(): 9.2e-153, (77.15% identity in 573 aa overlap).
C-terminal end is similar to many
1-acyl-SN-glycerol-3-phosphate acyltransferases
(lysophosphatidic acidacyltransferases) e.g. Q9SDQ2 from
Limnanthes floccosa (281 aa), FASTA scores: opt: 378, E():
3.1e-14, (30.0% identity in 230 aa overlap) and
Q42868|PLSC_LIMAL from Limnanthes alba (White meadowfoam)
(281 aa), FASTA scores: opt: 374, E(): 5.2e-14, (30.55%
identity in 221 aa overlap); and the N-terminal end is
similar to many SerB family proteins e.g. AAK44749|MT0526
from Mycobacterium tuberculosis strain CDC1551 (308
aa),FASTA scores: opt: 356, E(): 5.8e-13, (32.5% identity
in 298 aa overlap) and Q49823|ML2424 from Mycobacterium
leprae (300 aa), FASTA scores: opt: 346, E(): 2.1e-12,
(32.0% identity in 278 aa overlap). So belongs to the
1-acyl-SN-glycerol-3-phosphate acyltransferase family and
may belong to the SerB family."
/db_xref="EnsemblGenomes-Gn:Rv2483c"
/db_xref="EnsemblGenomes-Tr:CCP45277"
/db_xref="GOA:I6YDI9"
/db_xref="InterPro:IPR002123"
/db_xref="InterPro:IPR006385"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/TrEMBL:I6YDI9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45277.1"
/translation="MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDL
DGTLVAGFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAALAG
RLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFL
GINNMLTNKFETNEDGILTGGVLKPILWCPGKATAVQRFAAEHDIDLKDSYFYADGDE
DVALMYLVGNPRPTNPEGKMAAVAKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPV
AAGAVGIGVLTGSRRRGVNFFTSTFSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHR
NQVDPVIAGALVRDNWVGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVE
ERARNGLSIVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNST
TINPGTVDVAVFPPIPVDDWTLDALPDRIAEVRQLYLDTLADWPVDGLPAVDLYAEQK
AARKARAQVAKATAKRVPAKKAPAKSAANKGAAATKAATKKASPKAKPSESKIAGKDG
EASASPSSSAKGRS"
gene complement(2791019..2792494)
/locus_tag="Rv2484c"
CDS complement(2791019..2792494)
/codon_start=1
/transl_table=11
/locus_tag="Rv2484c"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv2484c, (MTV008.40c), len: 491 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004), highly
similar or similar to many Mycobacterial hypothetical
proteins e.g. Q9X7A8|MLCB1610.05|ML1244 conserved membrane
protein from Mycobacterium leprae (491 aa), FASTA scores:
opt: 2459, E(): 3e-138, (75.15% identity in 483 aa
overlap); O53304|YU87_MYCTU|Rv3087|MTV013.08 from
Mycobacterium tuberculosis (472 aa), FASTA scores: opt:
527, E(): 8.1e-24, (29.1% identity in 485 aa overlap);
O53305|YU88_MYCTU|Rv3088|MT3173|MTV013.09 from
Mycobacterium tuberculosis (474 aa), FASTA scores: opt:
370, E(): 1.6e-14, (26.05% identity in 422 aa overlap);
etc. A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2484c"
/db_xref="EnsemblGenomes-Tr:CCP45278"
/db_xref="GOA:P9WKB3"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WKB3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45278.1"
/translation="MAESGESPRLSDELGPVDYLMHRGEANPRTRSGIMALELLDGTP
DWDRFRTRFENASRRVLRLRQKVVVPTLPTAAPRWVVDPDFNLDFHVRRVRVSGPATL
REVLDLAEVILQSPLDISRPLWTATLVEGMADGRAAMLLHVSHAVTDGVGGVEMFAQI
YDLERDPPPRSTPPQPIPEDLSPNDLMRRGINHLPIAVVGGVLDALSGAVSMAGRAVL
EPVSTVSGILGYARSGIRVLNRAAEPSPLLRRRSLTTRTEAIDIRLADLHKAAKAGGG
SINDAYLAGLCGALRRYHEALGVPISTLPMAVPVNLRAEGDAAGGNQFTGVNLAAPVG
TIDPVARMKKIRAQMTQRRDEPAMNIIGSIAPVLSVLPTAVLEGITGSVIGSDVQASN
VPVYPGDTYLAGAKILRQYGIGPLPGVAMMVVLISRGGWCTVTVRYDRASVRNDELFA
QCLQAGFDEILALAGGPAPRVLPASFDTQGAGSVPRSVSGS"
gene complement(2792723..2793988)
/gene="lipQ"
/locus_tag="Rv2485c"
CDS complement(2792723..2793988)
/codon_start=1
/transl_table=11
/gene="lipQ"
/locus_tag="Rv2485c"
/product="Probable carboxylesterase LipQ"
/note="Rv2485c, (MTV008.41c), len: 421 aa. Probable
lipQ,carboxylesterase protein (lipase). Similar (greater
at the C-terminal end) to AAK46626|MT2342 putative
carboxylesterase from Mycobacterium tuberculosis strain
CDC1551 (431 aa), FASTA scores: opt: 1134, E():
4.3e-60,(46.25% identity in 428 aa overlap); and
Q50681|Rv2284|MTCY339.26c hypothetical protein from M.
tuberculosis strain H37Rv (431 aa), FASTA scores: opt:
1134, E(): 4.3e-60, (46.25% identity in 428 aa overlap).
Also similar in part to other putative lipases/esterases
e.g. AAK44451|MT0230 from Mycobacterium tuberculosis
strain CDC1551 (403 aa), FASTA scores: opt: 763, E():
4.6e-38,(37.95% identity in 390 aa overlap); Q9RY19|DR0133
from Deinococcus radiodurans (296 aa), FASTA scores: opt:
392,E(): 4e-16, (33.7% identity in 276 aa overlap);
Q9Z545|SC9B2.14 from Streptomyces coelicolor (502 aa)
FASTA scores: opt: 279, E(): 3.2e-09, (31.15% identity in
292 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2485c"
/db_xref="EnsemblGenomes-Tr:CCP45279"
/db_xref="GOA:I6Y9F7"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6Y9F7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45279.1"
/translation="MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGSPC
AIGWVAGWLSAEFPARVVTGHALSRISPRSIGRFGTSWAAQRADQILHAALVDAFGPD
FRDLVWHPTGEQSEAARRSGLLNLPHIPGPHRRYAAQTSDIPYGPGGRENLLDIWRRP
DLAPGRRAPVLIQVPGGAWTINGKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAH
IVDVKRAIAWVRENIADYGGDPDFITITGGSAGAHLAALAALSANDPALQPGFESADT
AVQAAAPYYGVYDLTNAENMHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYVHSEAP
PFFVLHGEKDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHAFDLAATVRSRMVAE
AVSDFLGVIYGRRMGARKGSLALSSPPAS"
gene 2794176..2794249
/gene="argW"
tRNA 2794176..2794249
/gene="argW"
/product="tRNA-Arg"
/anticodon=(pos:2794210..2794212,aa:Arg,seq:tct)
/note="codon recognized: AGA; argW, tRNA-Arg; anticodon
tct, length = 74"
gene 2794350..2795120
/gene="echA14"
/locus_tag="Rv2486"
CDS 2794350..2795120
/codon_start=1
/transl_table=11
/gene="echA14"
/locus_tag="Rv2486"
/product="Probable enoyl-CoA hydratase EchA14 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv2486, (MTV008.42), len: 256 aa. Probable
echA14,enoyl-CoA hydratase, similar to others e.g.
P24162|ECHH_RHOCA2|FADB1 from Rhodobacter capsulatus
(Rhodopseudomonas capsulata) (257 aa), FASTA scores; opt:
453, E(): 3.8e-23, (39.4% identity in 259 aa overlap);
Q9ETY7|PACA|PAAG from Azoarcus evansii (273 aa), FASTA
scores: opt: 404, E(): 5.7e-17, (37.5% identity in 224 aa
overlap); P77467|PAAG_ECOLI from Escherichia coli (262
aa),FASTA scores: opt: 401, E(): 8.3e-17, (36.3% identity
in 259 aa overlap); etc. Contains PS00166 Enoyl-CoA
hydratase/isomerase signature. Belongs to the enoyl-CoA
hydratase/isomerase family."
/db_xref="EnsemblGenomes-Gn:Rv2486"
/db_xref="EnsemblGenomes-Tr:CCP45280"
/db_xref="GOA:P9WNN5"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/Swiss-Prot:P9WNN5"
/inference="protein motif:PROSITE:PS00166"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45280.1"
/translation="MAQYDPVLLSVDKHVALITVNDPDRRNAVTDEMSAQLRAAIQRA
EGDPDVHAVVVTGAGKAFCAGADLSALGAGVGDPAEPRLLRLYDGFMAVSSCNLPTIA
AVNGAAVGAGLNLALAADVRIAGPAALFDARFQKLGLHPGGGATWMLQRAVGPQVARA
ALLFGMCFDAESAVRHGLALMVADDPVTAALELAAGPAAAPREVVLASKATMRATASP
GSLDLEQHELAKRLELGPQAKSVQSPEFAARLAAAQHR"
gene complement(2795301..2797385)
/gene="PE_PGRS42"
/locus_tag="Rv2487c"
CDS complement(2795301..2797385)
/codon_start=1
/transl_table=11
/gene="PE_PGRS42"
/locus_tag="Rv2487c"
/product="PE-PGRS family protein PE_PGRS42"
/note="Rv2487c, (MTV008.43c), len: 694 aa.
PE_PGRS42,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of Gly-rich proteins (see citation
below),similar to many e.g. AAK47245|MT2919 PE_PGRS family
protein from Mycobacterium tuberculosis strain CDC1515
(663 aa),FASTA scores: opt: 2317, E(): 2.3e-84, (58.35%
identity in 622 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2487c"
/db_xref="EnsemblGenomes-Tr:CCP45281"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:I6XEF1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45281.1"
/translation="MSLVIATPQLLATAALDLASIGSQVSAANAAAAMPTTEVVAAAA
DEVSAAIAGLFGAHARQYQALSVQVAAFHEQFVQALTAAAGRYASTEAAVERSLLGAV
NAPTEALLGRPLIGNGADGTAPGQPGAAGGLLFGNGGNGAAGGFGQTGGSGGAAGLIG
NGGNGGAGGTGAAGGAGGNGGWLWGNGGNGGVGGTSVAAGIGGAGGNGGNAGLFGHGG
AGGTGGAGLAGANGVNPTPGPAASTGDSPADVSGIGDQTGGDGGTGGHGTAGTPTGGT
GGDGATATAGSGKATGGAGGDGGTAAAGGGGGNGGDGGVAQGDIASAFGGDGGNGSDG
VAAGSGGGSGGAGGGAFVHIATATSTGGSGGFGGNGAASAASGADGGAGGAGGNGGAG
GLLFGDGGNGGAGGAGGIGGDGATGGPGGSGGNAGIARFDSPDPEAEPDVVGGKGGDG
GKGGSGLGVGGAGGTGGAGGNGGAGGLLFGNGGNGGNAGAGGDGGAGVAGGVGGNGGG
GGTATFHEDPVAGVWAVGGVGGDGGSGGSSLGVGGVGGAGGVGGKGGASGMLIGNGGN
GGSGGVGGAGGVGGAGGDGGNGGSGGNASTFGDENSIGGAGGTGGNGGNGANGGNGGA
GGIAGGAGGSGGFLSGAAGVSGADGIGGAGGAGGAGGAGGSGGEAGAGGLTNGPGSPG
VSGTEGMAGAPG"
gene complement(2797467..2800880)
/locus_tag="Rv2488c"
CDS complement(2797467..2800880)
/codon_start=1
/transl_table=11
/locus_tag="Rv2488c"
/product="Probable transcriptional regulatory protein
(LuxR-family)"
/note="Rv2488c, (MTV008.44c), len: 1137 aa. Probable
transcriptional regulatory protein, belonging to luxR
family, similar to many in Mycobacterium tuberculosis e.g.
AAK44621|MT0399 from strain CDC1551 (1092 aa) FASTA
scores: opt: 3767, E(): 1.8e-211, (56.75% identity in 1093
aa overlap); O53720|Rv0386|MTV036.21 from strain H37Rv
(1085 aa), FASTA scores: opt: 3756, E(): 7.6e-211, (56.75%
identity in 1089 aa overlap); AAK45665|MT1402 from strain
CDC1551 (1159 aa), FASTA scores: opt: 3395, E():
8.2e-190,(52.0% identity in 1093 aa overlap); etc. Also
similar to transcriptional regulatory proteins luxR-family
from other organisms e.g. Q9CBP3|ML1753 from Mycobacterium
leprae (1106 aa), FASTA scores: opt: 2823, E(): 1.5e-156,
(50.35% identity in 1116 aa overlap); Q9KYF4|SCD72A.02
from Streptomyces coelicolor (1114 aa), FASTA scores: opt:
915,E(): 1.7e-45, (30.7% identity in 1143 aa overlap);
etc. Some similarity with Q9KXP6|SC9C5.28 hypothetical
81.8 KDA protein from Streptomyces coelicolor (750 aa),
FASTA scores: opt: 1085, E(): 1.6e-55, (35.45% identity in
722 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop), PS00622 Bacterial regulatory proteins,
luxR family signature, probable coiled-coil from aa 585 to
616 and probable helix-turn-helix motif at aa 1086 to 1107
(score 1206, +3.29 SD). Belongs to the LuxR/UhpA family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv2488c"
/db_xref="EnsemblGenomes-Tr:CCP45282"
/db_xref="GOA:O53213"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR002182"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:O53213"
/inference="protein motif:PROSITE:PS00622"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45282.1"
/translation="MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWS
ADGVSELVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGVCPVEQ
GEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSSPDEGNCVGPTIDRT
ARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRLDDLPRPERVVQLCHPDLH
NAFPPLRTRKVVGAHCLPAQLTRLVGRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLA
TQVASAVADGYPDGVWYVNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDR
RMLVVLDNCEHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEA
IELFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALALTEIVDSL
HDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFRRLAVFPSGFDLDGAQAA
AAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTRYRLLETVRQYALEKLRESGDADAV
RARHRDHYAAVAAGLDAPSVAGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLAS
CLQPLWRARGRLQEGLAWFAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRL
DDAQKALAIARDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLA
EVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAANLWQGNLE
AAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAAAAAQASIDTAVGLSPV
LSGSACSALVFATLAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLN
AAHRLADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAYLWV
PDILECLASVMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMG
DSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWGALTPTELEVALLVGEGLSNK
EIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGESERGPSRP"
repeat_region 2800671..2800918
/note="248 bp direct repeat 2"
gene complement(2800846..2801145)
/locus_tag="Rv2489c"
CDS complement(2800846..2801145)
/codon_start=1
/transl_table=11
/locus_tag="Rv2489c"
/product="Hypothetical alanine rich protein"
/note="Rv2489c, (MTV008.45c), len: 99 aa. Hypothetical
unknown ala-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv2489c"
/db_xref="EnsemblGenomes-Tr:CCP45283"
/db_xref="UniProtKB/TrEMBL:O53214"
/protein_id="CCP45283.1"
/translation="MGVTAKAAEAAAPSSSFPSLRKPHRAGDSADRSAGDFDGTAHDA
VVSVLAGDAASTGGLTIASGQHGHCRSAAMARRSPNASTKARRTHGPAAKRFRAI"
gene complement(2801254..2806236)
/gene="PE_PGRS43"
/locus_tag="Rv2490c"
CDS complement(2801254..2806236)
/codon_start=1
/transl_table=11
/gene="PE_PGRS43"
/locus_tag="Rv2490c"
/product="PE-PGRS family protein PE_PGRS43"
/note="Rv2490c, (MTV008.46c), len: 1660 aa.
PE_PGRS43,Member of the Mycobacterium tuberculosis PE
family,PGRS-subfamily of Gly-rich proteins (see Brennan
and Delogu, 2002), similar to many e.g. AAK47971|MT3612.1
PE_PGRS family protein from Mycobacterium tuberculosis
strain CDC1551 (1715 aa), FASTA scores: opt: 5161, E():
1.5e-187, (51.7% identity in 1752 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2490c"
/db_xref="EnsemblGenomes-Tr:CCP45284"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FD4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45284.1"
/translation="MSYVIATPEMMATAAFDLARIGSQVSAASAVAAMPTTEVVAAGA
DEVSAGIAALFSAHAQEYQALSAQAAAFHDQFVHTLTAAARWYTATEIANAAAMRVVL
GAVNAPTQTLLGRPLIGDGAHGTAPGQPGGAGGLLFGNGGNGAAGAVGQVGGAGGAAG
LFGIGGAGGAGGAGAPGGTGGTGGWLAGGGGVGGMGGAGGGAGGAGGNAGLFGNGGAG
GAGGAGGGAGGAGGNAGWFGHGGAGGVGGVGAAGANGATPGQDGAAGVAGSDDGAGGD
GLAGSDGGDGGAGGVGGNGGRGGWLLGNGGAGGVGGVGGAGGAGAAGGAGGAGATGIN
GPAGISAAGGDGGAGGNGGAGGNGGVGGAGGAGGSAGLLGYVGRAGDGGAGGGGGLGG
APGDGGAGGNGGSWLAAGDGGAGGHGGDPGLGGAGGAGGASGGAGARAGANGLAAGND
GPVSGGNGGKGGNGAHAPVAGGHGGNGGAGGNGGLVGDGGAGGHGGDGAAGAGYADMT
AIFLGSSGTPGEDGGNGGAGGAGGAGGAHAGDGGAGGAGGNGGAGGAGGNGAHGFNAV
LVSDGGNGGDGGAGGRGGDGGAGGAGGDAPAGRAGSQGVGGDGGAGGAGGAPGNGGSG
GRGDMAFKDGDGGAGGDGGDPGAGGKGGAGGAGATEGVTGATGATVHSGGNGGKGGNG
ADATVAGANGGKGGAGGNGGLVGDGGAGGDGGSGAAGANGANVGEDGADGTLSGQPGE
GSEANGGQGGVGGGGAGGAGGDGGAGSSALGSGGNGGRGDAGQAGGAGGAGGAGGAGG
SVSGDGGPGGKGGAGGAGGAGASGGGGGKGASGADSAEAVGGAGGKGGDGGVGGVGGD
GGPGGDGGAGGAAPAGQVGSHGVGGVGGDGGLGGAGGNGGDGGHGSDGGDGGDGGDPG
AGGLGGLGGDSGNGTRAASGVDASDHGPGSGGNGGNGGNGAQASVAGGAGGNGGDGGN
AGRVGDGGAGGNGGDGAAGANGANSGAPGSDALALGQPGGNGGQGDAGQAGGAGGAGG
AGGAGGSVSGDGGAGGNGGAGGNGGVGASGGAGARGANGIDSIGGTGGAGGGGGDGGA
GGVGGHGGDGGVGGAAPSGTVGSHGTGGVGGDGGLGGAGGVGGAGGNGGIGITVGGAG
GAGGNGGDPGAGGRGGLGGDSGNGTSAANGVDASKHGPLTGGDGGVGGNGAKAAAAGG
DGGQGGDGGNAGLFGDGGAGGDGADGTAAEALGGDGGAGGAGGKGGDAGDIGDGGDGG
KGGDGAHGALGGLTVAGGNGGAGGAGGAGGAGGAFLGDGGNGGAGGQGGAGRGGSPGG
GGGVGGHGGAGGDAGMNGGGGTGGQGGNGAAGGAGWSPDSDLKGFDGFDGGSGGAGGD
GGAGGAGGTQTGDGGDGGAGGLGGAGGVGGNGVDGFDINETTGRDGGDGGDGGYGGWG
GAGGNGGAGGSAPAGEVGNRGVGGDGGDGGSGGDAGNGGLGGDGFTYLADFDGEPGGD
GGDGGDGGWGRPGGQGGFGSTSGAHGKAGFGAPGGDGGDGGNGGHGGDGNGSFADAGD
GGPGGNGGNGGLGGAGRDGGAPGGDGGDGGTGGSGGFGAPPPRSIGGGDGGDGGRGGD
GGRGAGGLTSGGVGSSGESGGSGNGRGDPGSGGSGGEGGEGGPSISVNVT"
repeat_region 2806368..2806625
/note="258 bp direct repeat 2. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 2806665..2807288
/locus_tag="Rv2491"
CDS 2806665..2807288
/codon_start=1
/transl_table=11
/locus_tag="Rv2491"
/product="Conserved hypothetical protein"
/note="Rv2491, (MTV008.47), len: 207 aa. Conserved
hypothetical protein, similar in part to other
hypothetical proteins e.g. O29139|AF1126 from
Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 293,
E(): 2.8e-11, (42.85% identity in 126 aa overlap);
O66531|AQ_134 from Aquifex aeolicus (151 aa), FASTA
scores: opt: 261, E(): 2.6e-09,(37.75% identity in 106 aa
overlap); Q9HKU3|TA0501 from Thermoplasma acidophilum (161
aa), FASTA scores: opt: 260,E(): 3.2e-09, (35.9% identity
in 117 aa overlap); etc. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv2491"
/db_xref="EnsemblGenomes-Tr:CCP45285"
/db_xref="InterPro:IPR005268"
/db_xref="InterPro:IPR041164"
/db_xref="UniProtKB/TrEMBL:I6XEF6"
/protein_id="CCP45285.1"
/translation="MVDTSAPASRLDTDPRRAHVSLSKHPYQIGVFGSGTIGPRVYEL
AYQVGAEIAKQGHILISGGMTGTMEASSRGASDADGLVVGVLPGDKFTDGNAYSTIKI
LSGMQFARNYITGLSCHGAIVVGGSSGAYEEARRVWEGRGPVVVLANSGSPTGASAQM
LSMQEIFGVAFPEDKPKPWRVFSAATPAESVSLVIGLIRKGYAQHEP"
gene 2807278..2808030
/locus_tag="Rv2492"
CDS 2807278..2808030
/codon_start=1
/transl_table=11
/locus_tag="Rv2492"
/product="Hypothetical protein"
/note="Rv2492, (MTV008.48), len: 250 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2492"
/db_xref="EnsemblGenomes-Tr:CCP45286"
/db_xref="InterPro:IPR036926"
/db_xref="UniProtKB/TrEMBL:I6YDJ7"
/protein_id="CCP45286.1"
/translation="MSRRIINEFGVQIYGATIGDTWAGLVRAVLDLGSQCFDEDRERI
ALSNVRIKSSVQNYPDLTIEEHCNSAQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYH
RRIKEGRMIEFVIERLSLIPESKKAVVVFPTYEDYAAVMRNHRDDYLPCLVSIQFRLL
PDGKDYVFHTTFYSRSMDAWQKGHGNLLSIAKLSDWVRENVSARIGRKIMLGPLDGMI
CDVHIYKETYAEACKRLANLDLRRTQFDAVRN"
gene 2808083..2808304
/gene="vapB38"
/locus_tag="Rv2493"
CDS 2808083..2808304
/codon_start=1
/transl_table=11
/gene="vapB38"
/locus_tag="Rv2493"
/product="Possible antitoxin VapB38"
/note="Rv2493, (MTV008.49), len: 73 aa. Possible
vapB38,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2494,see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis strain e.g. Rv3321c|MTV016.21c
hypothetical 8.8 KDA protein from Mycobacterium
tuberculosis strain H37Rv (80 aa). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2493"
/db_xref="EnsemblGenomes-Tr:CCP45287"
/db_xref="UniProtKB/Swiss-Prot:P9WJ25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45287.1"
/translation="MRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVE
ADDGLPVIRVPAGTPPITPEMVRRALDED"
gene 2808310..2808735
/gene="vapC38"
/locus_tag="Rv2494"
CDS 2808310..2808735
/codon_start=1
/transl_table=11
/gene="vapC38"
/locus_tag="Rv2494"
/product="Possible toxin VapC38. Contains PIN domain."
/note="Rv2494, (MTV008.50), len: 141 aa. Possible
vapC38,toxin, part of toxin-antitoxin (TA) operon with
Rv2493,contains PIN domain, see Arcus et al. 2005. Similar
to others in Mycobacterium tuberculosis e.g.
P95023|EMBL:Z83863|MTCY159.26|Rv2530c (139 aa) FASTA
scores: opt: 380 E(): 6.6e-19, (48.0% identity in 125 aa
overlap); O53372|Rv3320c|MTV016.20c (142 aa), etc. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2494"
/db_xref="EnsemblGenomes-Tr:CCP45288"
/db_xref="GOA:O53219"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:O53219"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45288.1"
/translation="MALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAG
FVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFLADDVSLVDDDVPLIVGYRQVTD
AHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL"
gene complement(2808758..2809939)
/gene="bkdC"
/locus_tag="Rv2495c"
CDS complement(2808758..2809939)
/codon_start=1
/transl_table=11
/gene="bkdC"
/locus_tag="Rv2495c"
/product="Probable branched-chain keto acid dehydrogenase
E2 component BkdC"
/note="Rv2495c, (MTCY07A7.01c-MTV008.51c), len: 393 aa.
Probable bkdC, branched-chain keto acid dehydrogenase, E2
component, similar to others e.g. Q9XA49|SCGD3.30c from
Streptomyces coelicolor (491 aa) FASTA scores: opt:
615,E(): 1.2e-28, (36.45% identity in 491 aa overlap;
several gaps); P19262|ODO2_YEAST|KGD2|YDR148C|YD8358.05c
from Saccharomyces cerevisiae (Baker's yeast) (463 aa)
FASTA scores: opt: 533, E(): 7.1e-24, (28.55% identity in
396 aa overlap); Q9HN75|DSA|VNG2219G from Halobacterium
sp. strain NRC-1 (478 aa), FASTA scores: opt: 521, E():
E(): 3.7e-23,(30.25% identity in 486 aa overlap; in part);
etc. Belongs to the 2-oxoacid dehydrogenase family.
Alternative nucleotide at position 2809621 (T->C; T107A)
has been observed. LpdC|Rv0462 co-immunoprecipitates with
DlaT|Rv2215 (in lpdC|Rv0462 mutant) and with BkdC|Rv2495c
(in dlaT|Rv2215 mutant) (See Venugopal et al., 2011).
Previously known as pdhC."
/db_xref="EnsemblGenomes-Gn:Rv2495c"
/db_xref="EnsemblGenomes-Tr:CCP45289"
/db_xref="GOA:O06159"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR001078"
/db_xref="InterPro:IPR004167"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR036625"
/db_xref="PDB:3L60"
/db_xref="UniProtKB/Swiss-Prot:O06159"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45289.1"
/translation="MSGEDSIRSFPVPDLGEGLQEVTVTCWSVAVGDDVEINQTLCSV
ETAKAEVEIPSPYAGRIVELGGAEGDVLKVGAELVRIDTGPTAVAQPNGEGAVPTLVG
YGADTAIETSRRTSRPLAAPVVRKLAKELAVDLAALQRGSGAGGVITRADVLAAARGG
VGAGPDVRPVHGVHARMAEKMTLSHKEIPTAKASVEVICAELLRLRDRFVSAAPEITP
FALTLRLLVIALKHNVILNSTWVDSGEGPQVHVHRGVHLGFGAATERGLLVPVVTDAQ
DKNTRELASRVAELITGAREGTLTPAELRGSTFTVSNFGALGVDDGVPVINHPEAAIL
GLGAIKPRPVVVGGEVVARPTMTLTCVFDHRVVDGAQVAQFMCELRDLIESPETALLD
L"
gene complement(2809936..2810982)
/gene="bkdB"
/locus_tag="Rv2496c"
CDS complement(2809936..2810982)
/codon_start=1
/transl_table=11
/gene="bkdB"
/locus_tag="Rv2496c"
/product="Probable branched-chain keto acid dehydrogenase
E1 component, beta subunit BkdB"
/note="Rv2496c, (MTCY07A7.02c), len: 348 aa. Probable
bkdB,branched-chain keto acid dehydrogenase E1 component,
beta subunit, similar to others e.g. Q9Y8I6||PDHB from
Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA
scores: opt: 1050, E(): 6.4e-60, (49.7% identity in 324 aa
overlap); Q9KG98|BH0214 from Bacillus halodurans (328
aa),FASTA scores: opt: 987, E(): 6.9e-56, (45.7% identity
in 324 aa overlap); Q9HN76|PDHB|VNG2218G from
Halobacterium sp. strain NRC-1 (297 aa), FASTA scores:
opt: 968, E(): 1.1e-54, (51.2% identity in 297 aa
overlap); P21874|ODPB_BACST|PDHB pyruvate dehydrogenase E1
component from Bacillus stearothermophilus (324 aa), FASTA
scores: opt: 951, E(): 1.4e-53, (47.6% identity in 321 aa
overlap); etc. Also similar to Q9XA61|SCGD3.17c putative
branched-chain alpha keto acid dehydrogenase E1, beta
subunit (2-oxoisovalerate dehydrogenase) from Streptomyces
coelicolor, (326 aa), FASTA scores: opt: 1178, E():
4.1e-68, (55.0% identity in 322 aa overlap);
Q9XA48|SCGD3.31c putative branched-chain alpha keto acid
dehydrogenase E1 beta subunit from Streptomyces coelicolor
(334 aa), FASTA scores: opt: 1173, E(): 8.8e-68, (55.6%
identity in 320 aa overlap); Q53593|BKDB E1-beta
branched-chain alpha keto acid dehydrogenase from
Streptomyces avermitilis (334 aa), FASTA scores: opt:
1132,E(): 3.7e-65, (55.0% identity in 320 aa overlap);
etc. Previously known as pdhB."
/db_xref="EnsemblGenomes-Gn:Rv2496c"
/db_xref="EnsemblGenomes-Tr:CCP45290"
/db_xref="GOA:P9WIS1"
/db_xref="InterPro:IPR005475"
/db_xref="InterPro:IPR009014"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR033248"
/db_xref="UniProtKB/Swiss-Prot:P9WIS1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45290.1"
/translation="MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADE
RVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPE
IQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWV
HTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAM
VRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRT
GRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGP
DRLLDCVERVLRQP"
gene complement(2810993..2812096)
/gene="bkdA"
/locus_tag="Rv2497c"
CDS complement(2810993..2812096)
/codon_start=1
/transl_table=11
/gene="bkdA"
/locus_tag="Rv2497c"
/product="Probable branched-chain keto acid dehydrogenase
E1 component, alpha subunit BkdA"
/note="Rv2497c, (MTCY07A7.03c), len: 367 aa. Probable
bkdA,branched-chain keto acid dehydrogenase E1 component,
alpha subunit, similar to many e.g. Q9Y8I5|PDHA from
Halobacterium volcanii (Haloferax volcanii) (368 aa) FASTA
scores: opt: 961, E(): 1.3e-52, (45.6% identity in 351 aa
overlap); BAB40585 from Bacillus sp. UTB2301 (356 aa)
FASTA scores: opt: 947, E(): 9.1e-52, (43.1% identity in
355 aa overlap); Q9KG99|BH0213 from Bacillus halodurans
(367 aa),FASTA scores: opt: 896, E(): 1.4e-48, (42.65%
identity in 340 aa overlap); etc. Also similar to several
putative branched-chain alpha keto acid dehydrogenases E1,
beta subunit, alternate name : 2-oxoisovalerate
dehydrogenase,e.g. Q53592|BKDA from Streptomyces
avermitilis (381 aa),FASTA scores: opt: 980, E(): 8.5e-54,
(45.65% identity in 370 aa overlap); etc. Previously known
as pdhA."
/db_xref="EnsemblGenomes-Gn:Rv2497c"
/db_xref="EnsemblGenomes-Tr:CCP45291"
/db_xref="GOA:P9WIS3"
/db_xref="InterPro:IPR001017"
/db_xref="InterPro:IPR017596"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/Swiss-Prot:P9WIS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45291.1"
/translation="MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETL
RWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRE
LGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLD
EDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIA
HKAIGYGMPGIRVDGNDVLACYAVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPT
RYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPD
FDVDEVFTTVYAEITPGLQAQREQLRAELARTD"
gene complement(2812355..2813176)
/gene="citE"
/locus_tag="Rv2498c"
CDS complement(2812355..2813176)
/codon_start=1
/transl_table=11
/gene="citE"
/locus_tag="Rv2498c"
/product="Probable citrate (pro-3S)-lyase (beta subunit)
CitE (citrase) (citratase) (citritase) (citridesmolase)
(citrase aldolase)"
/note="Rv2498c, (MTCY07A7.04c), len: 273 aa. Probable
citE,citrate lyase, beta subunit, similar to others e.g.
Q9S3L3|cite from Corynebacterium glutamicum
(Brevibacterium flavum) (217 aa), FASTA scores: opt: 565,
E(): 1.5e-28,(41.85% identity in 215 aa overlap);
Q9HRM8|cite|VNG0627G from Halobacterium sp. strain NRC-1
(303 aa), FASTA scores: opt: 535, E(): 1.5e-26, (41.65%
identity in 276 aa overlap); Q9S2U9|SC4G6.02 from
Streptomyces coelicolor (274 aa), FASTA scores: opt: 426,
E(): 1e-19, (37.6% identity in 274 aa overlap);
P77770|CILB_ECOLI from Escherichia coli (307 aa), FASTA
scores: opt: 265, E(): 1.5e-10, (32.8% identity in 265 aa
overlap); etc. Also similar to Rv3075c|MTCY22D7.06 from
Mycobacterium tuberculosis, FASTA score: (35.2% identity
in 264 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2498c"
/db_xref="EnsemblGenomes-Tr:CCP45292"
/db_xref="GOA:P9WPE1"
/db_xref="InterPro:IPR005000"
/db_xref="InterPro:IPR011206"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR040442"
/db_xref="PDB:1U5H"
/db_xref="PDB:1U5V"
/db_xref="PDB:1Z6K"
/db_xref="PDB:6AQ4"
/db_xref="UniProtKB/Swiss-Prot:P9WPE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45292.1"
/translation="MNLRAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQK
PAARNALRDTPLDPERTVVRINAGGTADQARDLEALAGTAYTTVMLPKAESAAQVIEL
APRDVIALVETARGAVCAAEIAAADPTVGMMWGAEDLIATLGGSSSRRADGAYRDVAR
HVRSTILLAASAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVR
KAYRPSHEKLAWARRVLAASRSERGAFAFEGQMVDSPVLTHAETMLRRAGEATSE"
gene complement(2813173..2813730)
/locus_tag="Rv2499c"
CDS complement(2813173..2813730)
/codon_start=1
/transl_table=11
/locus_tag="Rv2499c"
/product="Possible oxidase regulatory-related protein"
/note="Rv2499c, (MTCY07A7.05c), len: 185 aa. Possible
oxidase regulatory-related protein, similar to many maoC
monoamine oxidase regulatory protein e.g. Q9RUZ1|DR1239
MAOC-related protein from Deinococcus radiodurans (160
aa),FASTA scores: opt: 519, E(): 7.6e-28, (58.1% identity
in 148 aa overlap); BAB48392|MLR0905 Probable monoamine
oxidase regulatory protein from Rhizobium loti
(Mesorhizobium loti) (150 aa), FASTA scores: opt: 480,
E(): 2.9e-25, (49.0% identity in 149 aa overlap);
Q9HN18|MAOC1|VNG2290G monoamine oxidase regulatory-like
from Halobacterium sp. strain NRC-1 (208 aa), FASTA
scores: opt: 419, E(): 4.6e-21, (45.6% identity in 158 aa
overlap); P77455|MAOC_ECOLI|PAAZ|B1387 MaoC protein
(Phenylacetic acid degradation protein paaZ) from
Escherichia coli strain K12 (681 aa), FASTA scores: opt:
252, E(): 1.9e-09, (36.0% identity in 172 aa overlap);
etc. But also similar to other proteins with different
putative functions e.g. Q9HRM9|MAOC2|VNG0626G molybdenum
cofactor biosynthesis protein from Halobacterium sp strain
NRC-1 (157 aa), FASTA scores: opt: 380, E(): 1.5e-18,
(45.75% identity in 153 aa overlap); Q9KIF1 FKBR2 from
Streptomyces hygroscopicus var. ascomyceticus (175 aa),
FASTA scores: opt: 355, E(): 7.6e-17, (42.0% identity in
150 aa overlap); CAC36828|Q99Q03|SAPE Spore associated
protein from Streptomyces coelicolor (174 aa), FASTA
scores: opt: 318,E(): 2.2e-14, (41.45% identity in 152 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2499c"
/db_xref="EnsemblGenomes-Tr:CCP45293"
/db_xref="InterPro:IPR002539"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:I6Y9H2"
/protein_id="CCP45293.1"
/translation="MTKHAGDRESDDAVSACRVAGSTVGRRILQRGLWFEEFQIGTTY
LHRPGRTVTEADNVLFTTLTMNTQSLHLDAAWAGQQPGFRGERLVNSMFTLSTMVGLS
VAQLTLGTIVANLGFSEVSFPKPVFHGDTLYAETVCTGKRESKSRPGEGIVTLEHIAR
NQHGEVVARAVRTTLVQKQSIKEAQ"
gene complement(2813727..2814911)
/gene="fadE19"
/gene_synonym="mmgC"
/locus_tag="Rv2500c"
CDS complement(2813727..2814911)
/codon_start=1
/transl_table=11
/gene="fadE19"
/gene_synonym="mmgC"
/locus_tag="Rv2500c"
/product="Possible acyl-CoA dehydrogenase FadE19 (MMGC)"
/note="Rv2500c, (MTCY07A7.06c), len: 394 aa. Possible
fadE19 (alternate gene name: mmgC), acyl-CoA
dehydrogenase,similar to many e.g. Q9XCG6|ACDH from
Streptomyces coelicolor (386 aa), FASTA scores: opt: 1714,
E(): 1.1e-98,(69.45% identity in 383 aa overlap);
Q9XCG5|ACDH from Streptomyces avermitilis (386 aa), FASTA
scores: opt: 1713,E(): 1.3e-98, (70.0% identity in 383 aa
overlap); Q9L7W5|FENK from Bacillus subtilis (370 aa),
FASTA scores: opt: 1094, E(): 2.3e-60, (48.4% identity in
372 aa overlap); etc. Contains PS00072 Acyl-CoA
dehydrogenases signature 1, PS00073 Acyl-CoA
dehydrogenases signature 2. Belongs to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv2500c"
/db_xref="EnsemblGenomes-Tr:CCP45294"
/db_xref="GOA:I6Y0W5"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:I6Y0W5"
/inference="protein motif:PROSITE:PS00073"
/inference="protein motif:PROSITE:PS00072"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45294.1"
/translation="MTTTTTTISGGILPKEYQDLRDTVADFARTVVAPVSAKHDAEHS
FPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEELGKVDQSVAITLEAAVGLG
AMPIYRFGTEEQKQKWLPDLTSGRALAGFGLTEPGAGSDAGSTRTTARLEGDEWIING
SKQFITNSGTDITSLVTVTAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGW
NASDTHPLTFADARVPRENLLGARGSGYANFLSILDEGRIAIAALATGAAQGCVDESV
KYANQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKPFKKEAAIAK
MISSEAAMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLEIGEGTTEVQLMLIARSLG
LQ"
gene complement(2814916..2816880)
/gene="accA1"
/gene_synonym="bccA"
/locus_tag="Rv2501c"
CDS complement(2814916..2816880)
/codon_start=1
/transl_table=11
/gene="accA1"
/gene_synonym="bccA"
/locus_tag="Rv2501c"
/product="Probable acetyl-/propionyl-coenzyme A
carboxylase alpha chain (alpha subunit) AccA1: biotin
carboxylase + biotin carboxyl carrier protein (BCCP)"
/note="Rv2501c, (MTCY07A7.07c, P46401), len: 654 aa.
Probable accA1 (alternate gene name:
bccA),acetyl-/propionyl-coenzyme A carboxylase (alpha
subunit) [includes: biotin carboxylase ; biotin carboxyl
carrier protein (BCCP)], similar to others eg Q9L076|FABG
from Streptomyces coelicolor (646 aa), FASTA scores: opt:
2071,E(): 1e-113, (57.8% identity in 659 aa overlap);
AAK24139|Q9A6C6|CC2168 from Caulobacter crescentus (654
aa), FASTA scores: opt: 1754, E(): 3.7e-95, (47.2%
identity in 661 aa overlap); etc. Contains PS00188
Biotin-requiring enzymes attachment site, PS00866
Carbamoyl-phosphate synthase subdomain signature 1, and
PS00867 Carbamoyl-phosphate synthase subdomain signature
2."
/db_xref="EnsemblGenomes-Gn:Rv2501c"
/db_xref="EnsemblGenomes-Tr:CCP45295"
/db_xref="GOA:P9WPQ3"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR001882"
/db_xref="InterPro:IPR005479"
/db_xref="InterPro:IPR005481"
/db_xref="InterPro:IPR005482"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR011764"
/db_xref="InterPro:IPR016185"
/db_xref="UniProtKB/Swiss-Prot:P9WPQ3"
/inference="protein motif:PROSITE:PS00188"
/inference="protein motif:PROSITE:PS00867"
/inference="protein motif:PROSITE:PS00866"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45295.1"
/translation="MFDTVLVANRGEIAVRVIRTLRRLGIRSVAVYSDPDVDARHVLE
ADAAVRLGPAPARESYLDIGKVLDAAARTGAQAIHPGYGFLAENADFAAACERARVVF
LGPPARAIEVMGDKIAAKNAVAAFDVPVVPGVARAGLTDDALVTAAAEVGYPVLIKPS
AGGGGKGMRLVQDPARLPEALVSARREAMSSFGDDTLFLERFVLRPRHIEVQVLADAH
GNVVHLGERECSLQRRHQKVIEEAPSPLLDPQTRERIGVAACNTARCVDYVGAGTVEF
IVSAQRPDEFFFMEMNTRLQVEHPVTEAITGLDLVEWQLRVGAGEKLGFAQNDIELRG
HAIEARVYAEDPAREFLPTGGRVLAVFEPAGPGVRVDSSLLGGTVVGSDYDPLLTKVI
AHGADREEALDRLDQALARTAVLGVQTNVEFLRFLLADERVRVGDLDTAVLDERSADF
TARPAPDDVLAAGGLYRQWALARRAQGDLWAAPSGWRGGGHMAPVRTAMRTPLRSETV
SVWGPPESAQVQVGDGEIDCASVQVTREQMSVTISGLRRDYRWAEADRHLWIADERGT
WHLREAEEHKIHRAVGARPAEVVSPMPGSVIAVQVESGSQISAGDVVVVVEAMKMEHS
LEAPVSGRVQVLVSVGDQVKVEQVLARIKD"
gene complement(2816885..2818474)
/gene="accD1"
/locus_tag="Rv2502c"
CDS complement(2816885..2818474)
/codon_start=1
/transl_table=11
/gene="accD1"
/locus_tag="Rv2502c"
/product="Probable acetyl-/propionyl-CoA carboxylase (beta
subunit) AccD1"
/note="Rv2502c, (MTCY07A7.08c), len: 529 aa. Probable
accD1, acetyl-/propionyl-CoA carboxylase (beta subunit)
,similar, but with N-terminus shorter, to Q9L077|ACCD1
from Streptomyces coelicolor (538 aa), FASTA scores: opt:
2747,E(): 1.9e-159, (77.9% identity in 516 aa overlap).
Also similar to others e.g. AAK24141|CC2170 from
Caulobacter crescentus (530 aa), FASTA scores: opt: 2413,
E(): 3.8e-139, (69.4% identity in 529 aa overlap);
BAB54131|MLL7731 from Rhizobium loti (537 aa), FASTA
scores: opt: 2399, E(): 2.7e-138, (67.4% identity in 527
aa overlap); etc. Could belong to the ACCD/PCCB family."
/db_xref="EnsemblGenomes-Gn:Rv2502c"
/db_xref="EnsemblGenomes-Tr:CCP45296"
/db_xref="GOA:I6YDK7"
/db_xref="InterPro:IPR011762"
/db_xref="InterPro:IPR011763"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR034733"
/db_xref="PDB:4Q0G"
/db_xref="UniProtKB/TrEMBL:I6YDK7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45296.1"
/translation="MTTPSIAIAPSFADEHRRLVAELNNKLAAAALGGNERARKRHVS
RGKLLPRERVDRLLDPGSPFLELAPLAAGGMYGDESPGAGIITGIGRVSGRQCVIVAN
DATVKGGTYYPMTVKKHLRAQEVALQNMLPCIYLVDSGGAFLPRQDEVFPDREHFGRI
FYNQATMSAKGIPQVAAVLGSCTAGGAYVPAMSDEAVIVREQGTIFLGGPPLVKAATG
EIVSAEELGGGDLHSRTSGVTDHLADDDEDALRIVRAIADTFGPCEPAQWDVRRSVEP
KYPQAELYDVVPPDPRVPYDVHEVVVRIVDGSEFSEFKAKYGKTLVTAFARVHGHPVG
IVANNGVLFSESALKGAHFIELCDKRKIPLLFLQNIAGFMVGRDYEAGGIAKHGAKMV
TAVACARVPKLTVVIGGSYGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLAT
VRGEQLSAAGTPWSPDEEEAFKAPIRAQYEDQGNPYYSTARLWDDGIIDPADTRTVVG
LALSLCAHAPLDQVGYGVFRM"
gene complement(2818471..2819127)
/gene="scoB"
/locus_tag="Rv2503c"
CDS complement(2818471..2819127)
/codon_start=1
/transl_table=11
/gene="scoB"
/locus_tag="Rv2503c"
/product="Probable succinyl-CoA:3-ketoacid-coenzyme A
transferase (beta subunit) ScoB (3-oxo-acid:CoA
transferase) (OXCT B) (succinyl CoA:3-oxoacid
CoA-transferase)"
/note="Rv2503c, (MTCY07A7.09c, MT2578), len: 218 aa.
Probable scoB, 3-oxo acid:CoA transferase, beta subunit
(succinyl-CoA:3-ketoacid-CoA transferase). Highly similar
to others e.g. Q9XAM8|SC4C6.12c from Streptomyces
coelicolor (217 aa), FASTA scores: opt: 1048, E():
2.6e-60,(73.9% identity in 207 aa overlap); Q9XD82|PCAJ
from Streptomyces sp. 2065 (214 aa), FASTA scores: opt:
1031,E(): 3.2e-59, (70.8% identity in 209 aa overlap);
AAK53493|LPSJ from Xanthomonas campestris (pv. campestris)
(212 aa), FASTA scores: opt: 886, E(): 6.6e-50, (62.5%
identity in 208 aa overlap); P42316|SCOB_BACSU from
Bacillus subtilis (216 aa), FASTA scores: opt: 820, E():
1.2e-45, (58.2% identity in 201 aa overlap); etc. Belongs
to the 3-oxoacid CoA-transferase subunit B family."
/db_xref="EnsemblGenomes-Gn:Rv2503c"
/db_xref="EnsemblGenomes-Tr:CCP45297"
/db_xref="GOA:P9WPW3"
/db_xref="InterPro:IPR004164"
/db_xref="InterPro:IPR004165"
/db_xref="InterPro:IPR012791"
/db_xref="InterPro:IPR037171"
/db_xref="UniProtKB/Swiss-Prot:P9WPW3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45297.1"
/translation="MSAPGWSRDEMAARVAAEFEDGQYVNLGIGMPTLIPNHIPDGVH
VVLHSENGILGVGPYPRREDVDADLINAGKETVTTLPGAAFFSSSTSFGIIRGGHLDV
AVLGAMQVSVTGDLANWMIPGKMVKGMGGAMDLVHGARKVIVMMEHTAKDGSPKILER
CTLPLTGVGCVDRIVTELAVIDVCADGLHLVQTAPGVSVDEVVAKTQPPLVLRDLATQ
"
gene complement(2819124..2819870)
/gene="scoA"
/locus_tag="Rv2504c"
CDS complement(2819124..2819870)
/codon_start=1
/transl_table=11
/gene="scoA"
/locus_tag="Rv2504c"
/product="Probable succinyl-CoA:3-ketoacid-coenzyme A
transferase (alpha subunit) ScoA (3-oxo acid:CoA
transferase) (OXCT A) (succinyl-CoA:3-oxoacid-coenzyme A
transferase)"
/note="Rv2504c, (MT2579, MTCY07A7.10c), len: 248 aa.
Probable scoA, succinyl-CoA:3-ketoacid-Coenzyme A
transferase, alpha subunit (3-oxo acid:CoA transferase).
Highly similar to others e.g. Q9XAM7|SC4C6.13c from
Streptomyces coelicolor (260 aa), FASTA scores: opt:
1130,E(): 2.2e-64, (69.9% identity in 249 aa overlap);
Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA
scores: opt: 1121, E(): 8.1e-64, (69.5% identity in 249 aa
overlap); etc. Belongs to the 3-oxoacid CoA-transferase
subunit A family."
/db_xref="EnsemblGenomes-Gn:Rv2504c"
/db_xref="EnsemblGenomes-Tr:CCP45298"
/db_xref="GOA:P9WPW5"
/db_xref="InterPro:IPR004163"
/db_xref="InterPro:IPR004165"
/db_xref="InterPro:IPR012792"
/db_xref="InterPro:IPR037171"
/db_xref="UniProtKB/Swiss-Prot:P9WPW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45298.1"
/translation="MDKVVATAAEAVADIANGSSLAVGGFGLCGIPEALIAALVDSGV
TDLETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENKEFARQFLAGELEVELTPQGT
LAERLRAGGMGIPAFYTPAGVGTQVADGGLPWRYDASGGVAVVSPAKETREFDGVTYV
LERGIRTDFALVHAWQGDRHGNLMYRHAAANFNPECASAGRITIAEVEHLVEPGEIDP
ATVHTPGVFVHRVVHVPNPAKKIERETVRQ"
gene complement(2819953..2821596)
/gene="fadD35"
/locus_tag="Rv2505c"
CDS complement(2819953..2821596)
/codon_start=1
/transl_table=11
/gene="fadD35"
/locus_tag="Rv2505c"
/product="Probable fatty-acid-CoA ligase FadD35
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv2505c, (MTCY07A7.11c), len: 547 aa. Probable
fadD35, fatty-acid-CoA synthetase, highly similar to many
e.g. Q9Z5A6|SC2G5.17 from Streptomyces coelicolor (541
aa),FASTA scores: opt: 2202, E(): 8e-131, (61.55% identity
in 528 aa overlap); Q9F9U4|FADD from Pseudomonas stutzeri
(Pseudomonas perfectomarina), FASTA scores: opt: 1551,
E(): 7.3e-90, (55.55% identity in 551 aa overlap);
Q987S7|MLR6932 from Rhizobium loti (Mesorhizobium loti)
(590 aa), FASTA scores: opt: 1453, E(): 1.1e-83, (50.7%
identity in 564 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2505c"
/db_xref="EnsemblGenomes-Tr:CCP45299"
/db_xref="GOA:I6Y0X0"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:I6Y0X0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45299.1"
/translation="MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
LVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQYATAEIG
AILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAEVGPRCPDLADVILL
ESDRWDALAGAEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGY
LVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQD
ERCTSLYGVPTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVS
ICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCT
RGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRGGENIS
PREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIA
RFKIPRYLWIVDEFPMTVTGKVRKVEMRQQALEYLRGQQ"
gene 2821712..2822359
/locus_tag="Rv2506"
CDS 2821712..2822359
/codon_start=1
/transl_table=11
/locus_tag="Rv2506"
/product="Probable transcriptional regulatory protein
(probably TetR-family)"
/note="Rv2506, (MTCY07A7.12), len: 215 aa. Probable
transcriptional regulator, TetR family, similar to many
others e.g. Q9L078|SCC105.06c putative TetR-family
regulatory protein from Streptomyces coelicolor (208
aa),FASTA scores: opt: 333, E(): 1.5e-14, (48.75% identity
in 197 aa overlap); Q9X7X6|SC6A5.30c putative regulatory
protein from Streptomyces coelicolor (404 aa), FASTA
scores: opt: 267, E(): 4.8e-10, (30.45% identity in 207 aa
overlap) (similarity only with C-terminus for this one);
Q9FBI8|SCP8.33c putative TetR-family transcriptional
regulator from Streptomyces coelicolor (213 aa), FASTA
scores: opt: 239, E(): 1.8e-08, (29.9% identity in 184 aa
overlap); etc. Also similar to transcriptional regulatory
proteins from Mycobacterium tuberculosis e.g.
O05858|Rv3208|MTCY07D11.18c (228 aa), FASTA scores: opt:
218, E(): 4.4e-07, (30.35% identity in 191 aa overlap);
C-terminus of P95251|Rv1963c|MTV051.01c|MTCY09F9.01 (406
aa), FASTA scores: opt: 238, E(): 3.6e-08, (28.25%
identity in 177 aa overlap); P96839|Rv3557c|MTCY06G11.04c
(200 aa),FASTA scores: opt: 215, E(): 6.2e-07, (38.25%
identity in 148 aa overlap); etc. Equivalent to AAK46885
from Mycobacterium tuberculosis strain CDC1551 (231 aa)
but shorter 16 aa. Contains probable helix-turn-helix
motif at aa 46-67, (Score 1660, +4.84 SD). Belongs to the
TetR/AcrR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv2506"
/db_xref="EnsemblGenomes-Tr:CCP45300"
/db_xref="GOA:O06169"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041490"
/db_xref="UniProtKB/TrEMBL:O06169"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45300.1"
/translation="MTASAPDGRPGQPEATNRRSQLKSDRRFQLLAAAERLFAERGFL
AVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVTTRSANLAAAL
DGLIEFHLDFALGEADLIRIQDRDLAHLPAVAERQVRKAQRQYVEVWVGVLRELNPGL
AEADARLMAHAVFGLLNSTPHSMKAADSKPARTVRARAVLRAMTVAALSAADRCL"
gene 2822438..2823259
/locus_tag="Rv2507"
CDS 2822438..2823259
/codon_start=1
/transl_table=11
/locus_tag="Rv2507"
/product="Possible conserved proline rich membrane
protein"
/note="Rv2507, (MTCY07A7.13), len: 273 aa. Possible
conserved pro-rich membrane protein (N-terminal half is
Proline-rich), highly similar to Q9CCU3|ML0431 putative
membrane protein from Mycobacterium leprae (259 aa) (alias
O07711|MLCL383.38c but longer 2 aa), FASTA scores: opt:
968, E(): 1.4e-31, (60.35% identity in 275 aa overlap).
Contains potential membrane spanning region. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2507"
/db_xref="EnsemblGenomes-Tr:CCP45301"
/db_xref="GOA:O06170"
/db_xref="InterPro:IPR008693"
/db_xref="InterPro:IPR038468"
/db_xref="UniProtKB/TrEMBL:O06170"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45301.1"
/translation="MNDPRRPQRFGPPLSGYGPTGPQVPPNPPTADPAYADQSPYAST
YGGYVSPPWSPGGPPPRPPQWPPGPHEASPTQQLPQYWQYDQPPPGGFPPDGLTPPPP
QGPRTPRWLWFAAGSAVLLVVALVIALVIANGSVKKQTAIEPLPPMPGPSPTRPTTTT
PTPPSPSAAPAPTTTTGTPSETVAGAMQTVVYDVTGEGRAISITYMDSGNVIQTEFNV
ALPWRKEVSLSKSSLHPASVTIVNIGHNVTCSVTVAGVQVRQRTGAGLTICDAPS"
gene complement(2823256..2824593)
/locus_tag="Rv2508c"
CDS complement(2823256..2824593)
/codon_start=1
/transl_table=11
/locus_tag="Rv2508c"
/product="Probable conserved integral membrane leucine and
alanine rich protein"
/note="Rv2508c, (MTCY07A7.14c), len: 445 aa. Probable
conserved integral membrane leu-, ala-rich
protein,equivalent to Q9CCU4|ML0430 putative membrane
protein from Mycobacterium leprae (454 aa) (alias
O07710|MLCL383.37 longer 10 aa), FASTA scores: opt: 2205,
E(): 2.5e-124,(75.75% identity in 441 aa overlap). Also
similar to hypothetical or membrane proteins e.g.
BAB50841|MLL4103 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (458 aa), FASTA scores: opt: 396,
E(): 2.4e-16,(27.75% identity in 447 aa overlap);
Q9RKX9|SC6D7.19c putative integral membrane protein from
Streptomyces coelicolor (486 aa), FASTA scores: opt: 323,
E(): 5.7e-12,(28.95% identity in 428 aa overlap);
P42306|YXIO_BACSU probable integral membrane protein from
Bacillus subtilis (428 aa), FASTA scores: opt: 220, E():
7.2e-06, (20.35% identity in 413 aa overlap); etc. Also
similar to proteins from Mycobacterium tuberculosis e.g.
Q10564|Y876_MYCTU|Rv0876c|MT0899|MTCY31.04c (548 aa),
FASTA scores: opt: 184, E(): 0.0012, (24.7% identity in
466 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2508c"
/db_xref="EnsemblGenomes-Tr:CCP45302"
/db_xref="GOA:O06171"
/db_xref="InterPro:IPR024671"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O06171"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45302.1"
/translation="MNNPGSRAGTLLHFRVVAWAMWDCGSTGLNAIVTTFVFSVYLTS
AVGQGLPGGTSPASWLGRAGAVAGLTIGVLAPVVGVWVESPHRRRVALSVLTGTAVAL
TCAMFLIRDDPRYLWAGLVLLAATAASSDLSSVPYNAMLRQLSTPSTAGRISGFGWAS
GYVGSVALLLVIYLGFMSGSGSQRGLLQLPVANGLNVRMAMLVAAAWLALLGLPLLLV
AHRLPDSGAASHPSTGLLGGYRKLWTEISAEWRRDRNLVYFLVASAIFRDGLAAIFAF
GAVLGVNAYGLTQADVLIFGAAASVVAAVGAVLGGFVDHRIGSKPVIVGSLAAIIAAA
LTLLTLSGPTAFWACGLLLCVFIGPAQSSARALLLHMAQHGKEGVAFGLYTMTGRAVS
FLGPWLFSVFVDVFHTVRAGLGGVCLVLTTGLLLMLRVQVSRHGGALTTAQSS"
gene 2824678..2825484
/locus_tag="Rv2509"
CDS 2824678..2825484
/codon_start=1
/transl_table=11
/locus_tag="Rv2509"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv2509, (MTCY07A7.15), len: 268 aa. Probable
ala-rich oxidoreductase, short-chain
dehydrogenase/reductase, equivalent to
O07709|MLCL383.36c|ML0429 dehydrogenase (putative
oxidoreductase) from Mycobacterium leprae (268 aa), FASTA
scores: opt: 1509, E(): 2.6e-84, (88.75% identity in 267
aa overlap). Also highly similar to others e.g.
O86553|SC1F2.16c putative dehydrogenase from Streptomyces
coelicolor (276 aa), FASTA scores: opt: 492, E():
9.5e-23,(38.15% identity in 262 aa overlap); Q9I5R3|PA0658
probable short-chain dehydrogenase from Pseudomonas
aeruginosa (266 aa), FASTA scores: opt: 472, E(): 1.5e-21,
(37.8% identity in 246 aa overlap); AAK22120|CC0133
oxidoreductase (short-chain dehydrogenase/reductase
family) from Caulobacter crescentus (266 aa), FASTA
scores: opt: 428,E(): 6.9e-19, (35.8% identity in 243 aa
overlap); etc. Also highly similar or similar to
oxidoreductases from Mycobacterium tuberculosis e.g.
Q10782|Rv1544|MTCY48.21 putative ketoacyl reductase (267
aa), FASTA scores: opt: 656, E(): 1.1e-32, (43.05%
identity in 267 aa overlap). Contains PS00061 Short-chain
alcohol dehydrogenase family signature. Belongs to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv2509"
/db_xref="EnsemblGenomes-Tr:CCP45303"
/db_xref="GOA:I6Y9I3"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6Y9I3"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45303.1"
/translation="MPIPAPSPDARAVVTGASQNIGAALATELAARGHHLIVTARRED
VLTELAARLADKYRVTVDVRPADLADPQERSKLADELAARPISILCANAGTATFGPIA
SLDLAGEKTQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGNSPIPYNATYAAT
KAFVNTFSESLRGELRGSGVHVTVLAPGPVRTELPDASEASLVEKLVPDFLWISTEHT
ARVSLNALERNKMRVVPGLTSKAMSVASQYAPRAIVAPIVGAFYKRLGGS"
gene complement(2825488..2827089)
/locus_tag="Rv2510c"
CDS complement(2825488..2827089)
/codon_start=1
/transl_table=11
/locus_tag="Rv2510c"
/product="Conserved protein"
/note="Rv2510c, (MTCY07A7.16c), len: 533 aa. Conserved
protein, highly similar, but longer approximately 20 aa,
to others e.g. Q9ABY0|CC0090 hypothetical protein from
Caulobacter crescentus (516 aa), FASTA scores: opt:
1282,E(): 8.4e-63, (45.1% identity in 490 aa overlap);
Q9A130|SPY0500 hypothetical protein from Streptococcus
pyogenes (500 aa), FASTA scores: opt: 1281, E():
9.3e-63,(43.8% identity in 491 aa overlap); Q985L5|MLR7622
hypothetical protein from Rhizobium loti (Mesorhizobium
loti) (515 aa), FASTA scores: opt: 1259, E():
1.5e-61,(44.1% identity in 510 aa overlap);
P39342|YJGR_ECOLI|B4263 hypothetical 54.3 KDA protein from
Escherichia coli strain K12 (500 aa), FASTA scores: opt:
1257, E(): 1.9e-61, (42.7% identity in 501 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2510c"
/db_xref="EnsemblGenomes-Tr:CCP45304"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR033186"
/db_xref="UniProtKB/TrEMBL:I6Y0X6"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45304.1"
/translation="MGTESAAGGPGGPAQRIAAGYTVEGQALQLGTVVVDGEPDPSAQ
IRIPLATVNRHGLVAGATGTGKTKTLQLIAEQLSAAGVAVLMADVKGDLSGLARPGEA
ADKTAARAKDTGDDWVPTAFPVEFLSLGASGVGVPVRATISSFGPILLAKVLGLNATQ
ESTLGLIFHWADQRGLPLLDLKDLRAVITHLTSDEGKVELKSLGAVSPTTAGVILRAL
VNLEAEGADTFFGEPELRPEDLLRVDSQGRGIISLLEFGSQALRPAMFSTFLMWVLAD
LFTFLPEVGDLDKPKLVFFFDEAHLLFTDASKAFLEQVEQTVKLIRSKGVGVFFCTQL
PTDLPNDVLSQLGARIQHALRAFTPDDHKALRKTVRTYPKTDVYDLESALTSLGTGEA
VVTVLSEKGAPTPVAWTRMRAPRSLMAAIGAEAIGAAAQASSLQAVYGQTIDRPSAHE
ILSAKLAPAQEAPAQEAPAPRGQYDPLPWPDDFEVPPMPAPVEPQGPAVWEEILKNPT
VKSVLNTTAREITRSIFGTGRRRRK"
gene 2827157..2827804
/gene="orn"
/locus_tag="Rv2511"
CDS 2827157..2827804
/codon_start=1
/transl_table=11
/gene="orn"
/locus_tag="Rv2511"
/product="Oligoribonuclease Orn"
/note="Rv2511, (MTCY07A7.17), len: 215 aa.
Orn,oligoribonuclease, equivalent to
O07708|ORN_MYCLE|ORN|ML0427|MLCL383.34c oligoribonuclease
from Mycobacterium leprae (215 aa), FASTA scores: opt:
1170, E(): 3.5e-65, (84.5% identity in 213 aa overlap).
Also highly similar to many e.g. P57667|ORN_STRGR|ORNA
from Streptomyces griseus (201 aa), FASTA scores: opt:
807, E(): 7.7e-43, (59.0% identity in 200 aa overlap);
ORN_STRCO|ORNA|2SC13.01 from Streptomyces coelicolor (200
aa), FASTA scores: opt: 799, E(): 2.4e-42, (59.7% identity
in 201 aa overlap); P39287|ORN_ECOLI|B4162 from
Escherichia coli strain K12 (180 aa), FASTA scores: opt:
519, E(): 3.9e-25, (47.4% identity in 173 aa overlap);
etc. Belongs to the oligoribonuclease family."
/db_xref="EnsemblGenomes-Gn:Rv2511"
/db_xref="EnsemblGenomes-Tr:CCP45305"
/db_xref="GOA:P9WIU1"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR013520"
/db_xref="InterPro:IPR022894"
/db_xref="InterPro:IPR036397"
/db_xref="UniProtKB/Swiss-Prot:P9WIU1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45305.1"
/translation="MQDELVWIDCEMTGLDLGSDKLIEIAALVTDADLNILGDGVDVV
MHADDAALSGMIDVVAEMHSRSGLIDEVKASTVDLATAEAMVLDYINEHVKQPKTAPL
AGNSIATDRAFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPPKGLTHRAL
ADIHESIRELRFYRRTAFVPQPGPSTSEIAAVVAELSDGAGAQEETDSAEAPQSG"
gene 2827854..2827926
/gene="hisT"
tRNA 2827854..2827926
/gene="hisT"
/product="tRNA-His"
/anticodon=(pos:2827887..2827889,aa:His,seq:gtg)
/note="codon recognized: CAC; hisT, tRNA-His, anticodon
gtg, length = 73"
mobile_element complement(2828489..2829938)
/mobile_element_type="insertion sequence:IS1081-3"
/note="IS1081-3, len: 1450 nt. Insertion sequence IS1081."
gene complement(2828556..2829803)
/locus_tag="Rv2512c"
CDS complement(2828556..2829803)
/codon_start=1
/transl_table=11
/locus_tag="Rv2512c"
/product="Transposase for insertion sequence element
IS1081"
/note="Rv2512c, (MTCY07A7.18c), len: 415 aa. Transposase
for IS1081, identical to P35882|TRA1_MYCBO transposase for
insertion sequence element IS1081 from Mycobacterium bovis
(415 aa), FASTA scores: opt: 2680, E(): 1.9e-162, (100.0%
identity in 415 aa overlap). Also highly similar to others
from Mycobacterium tuberculosis e.g.
P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV01
2.38c (415 aa), FASTA scores: opt: 2675, E(): 3.9e-162,
(99.75% identity in 415 aa overlap). Contains PS00435
Peroxidases proximal heme-ligand signature, PS01007
Transposases,Mutator family, signature. Belongs to the
mutator family of transposase."
/db_xref="EnsemblGenomes-Gn:Rv2512c"
/db_xref="EnsemblGenomes-Tr:CCP45306"
/db_xref="GOA:P60230"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/Swiss-Prot:P60230"
/inference="protein motif:PROSITE:PS01007"
/inference="protein motif:PROSITE:PS00435"
/protein_id="CCP45306.1"
/translation="MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADAL
CGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERA
LTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGP
YTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRD
LVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRT
LLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIW
SNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRA
RAALTSTEEPAKQQTTNTPALTT"
gene 2830161..2830583
/locus_tag="Rv2513"
CDS 2830161..2830583
/codon_start=1
/transl_table=11
/locus_tag="Rv2513"
/product="Hypothetical protein"
/note="Rv2513, (MTCY07A7.19), len: 140 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2513"
/db_xref="EnsemblGenomes-Tr:CCP45307"
/db_xref="UniProtKB/TrEMBL:O06175"
/protein_id="CCP45307.1"
/translation="MDDIAAFKLDSLPDITFTVTRAISSGGENPAGFLNFAARREQPE
ILGGGGRPGPVGPEAVDTPRIRGGKVPFVFRTLPGYTFYASQIEPRVGDPEGPTLLAG
FGNIPETSQRSPGWIRITCTGPDDDEELEFFGFAGPES"
gene complement(2830877..2831338)
/locus_tag="Rv2514c"
CDS complement(2830877..2831338)
/codon_start=1
/transl_table=11
/locus_tag="Rv2514c"
/product="Conserved hypothetical protein"
/note="Rv2514c, (MTCY07A7.20c), len: 153 aa. Conserved
hypothetical protein, showing some similarity to
Q9PG05|XF0497 hypothetical protein from Xylella fastidiosa
(155 aa), FASTA scores: opt: 215, E(): 1.4e-07, (30.6%
identity in 160 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2514c"
/db_xref="EnsemblGenomes-Tr:CCP45308"
/db_xref="InterPro:IPR016541"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/TrEMBL:I6Y0Y0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45308.1"
/translation="MLYSFDTSAILNGRRDLFRPAVFRSLWGRVEDAISAGQIRSVDE
VQRELARRDDDAKRWADGQTGLFCPLDEQIQQAARHILRLHPNMVRQGGRRSAADPFV
IALAMVNNATVVTQETASGNIEKPRIPDVCDALGVPWLTLMGYIEAQGWTF"
gene complement(2831344..2832591)
/locus_tag="Rv2515c"
CDS complement(2831344..2832591)
/codon_start=1
/transl_table=11
/locus_tag="Rv2515c"
/product="Conserved hypothetical protein"
/note="Rv2515c, (MTCY07A7.21c), len: 415 aa. Conserved
hypothetical protein, showing some similarity to
Q9PG06|XF0496 hypothetical protein from Xylella fastidiosa
(391 aa), FASTA scores: opt: 388, E(): 4.4e-18, (27.8%
identity in 399 aa overlap). Contains PS00142 Neutral zinc
metallopeptidases, zinc-binding region signature."
/db_xref="EnsemblGenomes-Gn:Rv2515c"
/db_xref="EnsemblGenomes-Tr:CCP45309"
/db_xref="GOA:I6XEH5"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010359"
/db_xref="InterPro:IPR010982"
/db_xref="UniProtKB/TrEMBL:I6XEH5"
/inference="protein motif:PROSITE:PS00142"
/protein_id="CCP45309.1"
/translation="MGIGHPMWVGWCIIIAMRSIPASVESSVLRWARESCGLTEVAAA
RKLGLPDDRVAAWEVGEVVPTIAQLRKAAEVYKRSLAVFFLSEPPEGFDTLRDFRRLD
GAASGQWTPGLHEEFRRAHTQRDFALELADAEDREIPGAWRLPLSGDEADADIAARIR
KALIEVSPLPIPVASVDPYEHLNAWVSAIETSGVLVLATRGGKVAIDEMRGMCLYFDE
LPVIVLNGSDHPRPRLFSLLHEFVHVVLHTEGLCDVIADAHPSTQDRSLEARCNAIAA
AVLMPADVVRARPEVIVRSETPSSWDYESLRPVAAHFGVSAEAFLRRLSTLGIVPVEV
YRQRRAEFIAAHEDEAERARSAGGGNWYRNTVRDLGKGYVRAVTDAHRRRVIDSNTAA
IYLDAKVSQIPKLAESAELRSVV"
gene complement(2832710..2833513)
/locus_tag="Rv2516c"
CDS complement(2832710..2833513)
/codon_start=1
/transl_table=11
/locus_tag="Rv2516c"
/product="Hypothetical protein"
/note="Rv2516c, (MTV009.01c), len: 267 aa. Hypothetical
unknown protein. Contains probable helix-turn-helix motif
at aa 98 to 119 (Score 1743, +5.12 SD). C-terminus
extended since first submission (+ 18 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2516c"
/db_xref="EnsemblGenomes-Tr:CCP45310"
/db_xref="UniProtKB/TrEMBL:I6YDM0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45310.1"
/translation="MTADWVVTFTFDADPSMETMDAWETQLEGFDALVSRVPGHGIDV
TVYAPGDWSVFDALAKMAGEVMPVVQAKSPIAVQIISEPEHRLRAEAFTTPELMSAAE
IADELGVSRQRVHQLRSTAGFPAPLADLRGGAVWDAAAVRRFAETWERKPGRPHTGTA
KFAYSWAVGPAVGRSGKAPNVRWRVENPDKIRFVLRNIGDDIAEDVEIDLSRIDAITR
NVPKKTVIRPGEGLNMVLIAAWGHPLPNQLYVRWAGQDEWAAVPLHPAH"
gene complement(2833510..2833761)
/locus_tag="Rv2517c"
CDS complement(2833510..2833761)
/codon_start=1
/transl_table=11
/locus_tag="Rv2517c"
/product="Unknown protein"
/note="Rv2517c, (MTV009.02c), len: 83 aa. Unknown protein.
Equivalent to AAK46899 from Mycobacterium tuberculosis
strain CDC1551 (97 aa) but shorter 14 aa."
/db_xref="EnsemblGenomes-Gn:Rv2517c"
/db_xref="EnsemblGenomes-Tr:CCP45311"
/db_xref="UniProtKB/TrEMBL:O53222"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45311.1"
/translation="MNSAIIKIAKWAQSQQWTVEDDASGYTRFYNPQGVYIARFPATP
SNEYRRMRDLLGALKKAGLTWPPPSKKERRAQHRKEGAQ"
gene complement(2834109..2835335)
/gene="ldtB"
/locus_tag="Rv2518c"
CDS complement(2834109..2835335)
/codon_start=1
/transl_table=11
/gene="ldtB"
/locus_tag="Rv2518c"
/product="Probable L,D-transpeptidase LdtB"
/note="Rv2518c, (MTV009.03c), len: 408 aa. Probable
ldtB,L,D-transpeptidase, highly similar to
O07707|MLCL383.3 hypothetical 43.6 KDA protein from
Mycobacterium leprae (407 aa), FASTA scores: opt: 2300,
E(): 1.2e-130, (82.5% identity in 406 aa overlap);
Q9CCU5|LPPS|ML0426 putative secreted protein from
Mycobacterium leprae (404 aa), FASTA scores: opt: 2279,
E(): 2.3e-129, (82.4% identity in 403 aa overlap); and
Q9CB49|ML2446 possible lipoprotein from Mycobacterium
leprae (441 aa), FASTA scores: opt: 736, E(): 8.4e-37,
(35.6% identity in 399 aa overlap). Also similar to other
proteins from several organisms e.g. Q9X811|SC6G10.26c
putative secreted protein from Streptomyces coelicolor
(424 aa), FASTA scores: opt: 867,E(): 1.1e-44, (32.25%
identity in 403 aa overlap); Q9L1E8|SC3D11.14 putative
lipoprotein from Streptomyces coelicolor (416 aa), FASTA
scores: opt: 737, E(): 7e-37,(32.95% identity in 413 aa
overlap); Q9KYV1|SCE22.11 putative lipoprotein from
Streptomyces coelicolor (407 aa),FASTA scores: opt: 721,
E(): 6.2e-36, (33.5% identity in 400 aa overlap). And
similar to several hypothetical mycobacterial proteins
e.g. Q11149|Y483_MYCTU|Rv0483|MT0501|MTCY20G9.09 (451 aa),
FASTA scores: opt: 763, E(): 2.1e-38, (34.85% identity in
402 aa overlap). Has very long signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site. Note that previously
known as lppS"
/db_xref="EnsemblGenomes-Gn:Rv2518c"
/db_xref="EnsemblGenomes-Tr:CCP45312"
/db_xref="GOA:I6Y9J2"
/db_xref="InterPro:IPR005490"
/db_xref="InterPro:IPR038063"
/db_xref="InterPro:IPR041280"
/db_xref="PDB:3VYN"
/db_xref="PDB:3VYO"
/db_xref="PDB:3VYP"
/db_xref="PDB:4GSQ"
/db_xref="PDB:4GSR"
/db_xref="PDB:4GSU"
/db_xref="PDB:4HU2"
/db_xref="PDB:4HUC"
/db_xref="PDB:4QR7"
/db_xref="PDB:4QRA"
/db_xref="PDB:4QRB"
/db_xref="PDB:4QTF"
/db_xref="PDB:5D7H"
/db_xref="PDB:5DC2"
/db_xref="PDB:5DCC"
/db_xref="PDB:5DU7"
/db_xref="PDB:5DUJ"
/db_xref="PDB:5DVP"
/db_xref="PDB:5DZJ"
/db_xref="PDB:5DZP"
/db_xref="PDB:5E1G"
/db_xref="PDB:5E1I"
/db_xref="PDB:5K69"
/db_xref="PDB:5LB1"
/db_xref="PDB:5LBG"
/db_xref="PDB:6IYV"
/db_xref="PDB:6IYW"
/db_xref="UniProtKB/Swiss-Prot:I6Y9J2"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45312.1"
/translation="MPKVGIAAQAGRTRVRRAWLTALMMTAVMIGAVACGSGRGPAPI
KVIADKGTPFADLLVPKLTASVTDGAVGVTVDAPVSVTAADGVLAAVTMVNDNGRPVA
GRLSPDGLRWSTTEQLGYNRRYTLNATALGLGGAATRQLTFQTSSPAHLTMPYVMPGD
GEVVGVGEPVAIRFDENIADRGAAEKAIKITTNPPVEGAFYWLNNREVRWRPEHFWKP
GTAVDVAVNTYGVDLGEGMFGEDNVQTHFTIGDEVIATADDNTKILTVRVNGEVVKSM
PTSMGKDSTPTANGIYIVGSRYKHIIMDSSTYGVPVNSPNGYRTDVDWATQISYSGVF
VHSAPWSVGAQGHTNTSHGCLNVSPSNAQWFYDHVKRGDIVEVVNTVGGTLPGIDGLG
DWNIPWDQWRAGNAKA"
gene 2835494..2835566
/gene="lysU"
tRNA 2835494..2835566
/gene="lysU"
/product="tRNA-Lys"
/anticodon=(pos:2835527..2835529,aa:Lys,seq:ctt)
/note="codon recognized: AAG; lysU, tRNA-Lys, anticodon
ctt, length = 73"
gene 2835785..2837263
/gene="PE26"
/locus_tag="Rv2519"
CDS 2835785..2837263
/codon_start=1
/transl_table=11
/gene="PE26"
/locus_tag="Rv2519"
/product="PE family protein PE26"
/note="Rv2519, (MTV009.04), len: 492 aa. PE26, Member of
the M. tuberculosis PE family (see citation below), highly
similar to many e.g.
Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543
aa),FASTA scores: opt: 848, E(): 3e-30, (39.55% identity
in 445 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2519"
/db_xref="EnsemblGenomes-Tr:CCP45313"
/db_xref="GOA:Q79FD3"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR001969"
/db_xref="InterPro:IPR021109"
/db_xref="UniProtKB/TrEMBL:Q79FD3"
/protein_id="CCP45313.1"
/translation="MSRLIVAPDWLASAAAEVQSIGSALSAANAAAAAPTTLLVAAAE
DEVSAAAAALFANYGREYQTLSVRFASLDQQFAQALNSAAASYQTAEATGASLVQTAT
QGVLGVINAPTEFMFGRSLIGDGADGTAASPIGEPGGILYGDGGNGYSQTTPGAVGGA
GGSAGFIGNGGAGGAGGPGAGGGTGGLGGWLWGNNGAAGTGDPVNVAVPLRVENNFPL
VNLLVNRGPTVPILLDTGSSSLVIPFWKIGWQNLGLPTGFDVVHYGNGVSIVYADVPT
TVDFGGGAATTPTSVHVGILPYPRNLDSLVLIASGGAFGPNGNGILGIGPNVGSYAVS
GPGNVVTTDLPGQLNEGTLIDIPGGYMQFGPNTGTPITSVTGAPITVLNVQIGGYDPN
GGYWSLPSIFDSGGNHGTLPAVILGTGQTTGYAPPGTVISISIHDNQTLLYQYTTTAS
NSPVVTADPRLNTGLTPFLLGPVYISNNPSGVGTVVFNYPPP"
gene complement(2837388..2837615)
/locus_tag="Rv2520c"
CDS complement(2837388..2837615)
/codon_start=1
/transl_table=11
/locus_tag="Rv2520c"
/product="Possible conserved membrane protein"
/note="Rv2520c, (MTV009.05c), len: 75 aa. Possible
conserved membrane protein, equivalent to
O07706|MLCL383.32 hypothetical 10.0 KDA protein from
Mycobacterium leprae (91 aa), FASTA scores: opt: 290, E():
4.1e-14, (58.65% identity in 75 aa overlap); and
Q9CCU6|ML0425 putative membrane protein from Mycobacterium
leprae (75 aa), FASTA scores: opt: 286, E(): 6.6e-14,
(57.35% identity in 75 aa overlap). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2520c"
/db_xref="EnsemblGenomes-Tr:CCP45314"
/db_xref="GOA:I6XEI0"
/db_xref="InterPro:IPR022062"
/db_xref="UniProtKB/TrEMBL:I6XEI0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45314.1"
/translation="MVDRDPNTIKQEIDQTRDQLAATIDSLAERANPRRLADDAKTRV
IAFLRKPIVTVSLVGIGSVVVVVVIHKIRNR"
gene 2837684..2838157
/gene="bcp"
/locus_tag="Rv2521"
CDS 2837684..2838157
/codon_start=1
/transl_table=11
/gene="bcp"
/locus_tag="Rv2521"
/product="Probable bacterioferritin comigratory protein
Bcp"
/note="Rv2521, (MTV009.06), len: 157 aa. Probable
bcp,bacterioferritin comigratory protein, equivalent to
O07705|BCP|ML0424 from Mycobacterium leprae (161 aa),
FASTA scores: opt: 829, E(): 6.8e-46, (79.6% identity in
157 aa overlap). Also highly similar to Q9KZQ2|SCE6.38
hypothetical 16.8 KDA protein Streptomyces coelicolor (155
aa), FASTA scores: opt: 727, E(): 2e-39, (69.5% identity
in 154 aa overlap);
P23480|AAG57590|BCP_ECOLI|B2480|BAB36765|Z3739|ECS3342
bacterioferritin comigratory protein from Escherichia coli
strain K12 (156 aa), FASTA scores: opt: 513, E():
8.3e-26,(48.3% identity in 149 aa overlap); Q9RW23|DR0846
bacterioferritin comigratory protein from Deinococcus
radiodurans (175 aa), FASTA scores: opt: 465, E():
1e-22,(46.5% identity in 157 aa overlap);
P44411|BCP_HAEIN|HI0254 bacterioferritin comigratory
protein from Haemophilus influenzae (155 aa), FASTA
scores: opt: 453, E(): 5.3e-22,(47.5% identity in 139 aa
overlap); etc. Also similar to Mycobacterium tuberculosis
Rv1608c|MTV046.06|bcpB and Rv2238c|MTCY427.19c|hpE."
/db_xref="EnsemblGenomes-Gn:Rv2521"
/db_xref="EnsemblGenomes-Tr:CCP45315"
/db_xref="GOA:P9WIE1"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR024706"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/Swiss-Prot:P9WIE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45315.1"
/translation="MTKTTRLTPGDKAPAFTLPDADGNNVSLADYRGRRVIVYFYPAA
STPGCTKQACDFRDNLGDFTTAGLNVVGISPDKPEKLATFRDAQGLTFPLLSDPDREV
LTAWGAYGEKQMYGKTVQGVIRSTFVVDEDGKIVVAQYNVKATGHVAKLRRDLSV"
gene complement(2838129..2839541)
/locus_tag="Rv2522c"
CDS complement(2838129..2839541)
/codon_start=1
/transl_table=11
/locus_tag="Rv2522c"
/product="Conserved hypothetical protein"
/note="Rv2522c, (MTV009.07c), len: 470 aa. Conserved
hypothetical protein, equivalent, but longer 20 aa, to
Q9X7E4|ML1193|MLCB458.08 from hypothetical 46.6 KDA
protein Mycobacterium leprae (442 aa), FASTA scores: opt:
2521,E(): 4.1e-142, (86.35% identity in 440 aa overlap).
Also similar to various proteins e.g. Q9K425|SCG22.20
putative peptidase from Streptomyces coelicolor (451 aa),
FASTA scores: opt: 1097, E(): 1.1e-57, (42.5% identity in
451 aa overlap); Q9FCK3|2SC3B6.09 putative peptidase from
Streptomyces coelicolor (470 aa), FASTA scores: opt:
669,E(): 2.8e-32, (34.2% identity in 462 aa overlap);
Q98AF9|MLL6018 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (486 aa), FASTA scores: opt: 622,
E(): 1.7e-29, (33.95% identity in 442 aa overlap);
Q9RSU7|DR2025 ARGE/DAPE/ACY1 family protein from
Deinococcus radiodurans (459 aa), FASTA scores: opt: 616,
E(): 3.7e-29, (34.15% identity in 442 aa overlap); etc
(include some similarity to hypothetical proteins from C.
elegans and yeast). Alternative start possible at 6687 but
then no RBS obvious."
/db_xref="EnsemblGenomes-Gn:Rv2522c"
/db_xref="EnsemblGenomes-Tr:CCP45316"
/db_xref="GOA:I6X4J0"
/db_xref="InterPro:IPR002933"
/db_xref="InterPro:IPR011650"
/db_xref="UniProtKB/TrEMBL:I6X4J0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45316.1"
/translation="MSASRRRIASKSGFSCDSASARELVERVREVLPSVRCDLEELVR
IESVWADPDRRDEVHRSARAVADLLSQAGFDDVRIVSERGAPAVIARYPAPPGAPTVL
LYAHHDVQPEGDRGQWVSPPFEPTERGGRLYGRGTADDKAGIATHVAAFWAHGGRPPV
GVTVFVEGEEESGSPSLGRLLAAHRDALAADVIVIADSDNWSTDIPALTVSLRGMADC
VVEVATLDHGLHSGLWGGVVPDALTVLVRLLASLHDDDGNVAVAGMHESTAARVDYPA
GRVRAESGLLDGVSEIGTGSVPQRLWAKPAITVIGIDTTSVAAASNTLIPRARAKISI
RVAPGGDATAHLDAVEAHLRRHAPWGAQVTVTRGEVGQPYAIEASGPVYDAARSAFRQ
AWGADPIDMGMGGSIPFIAEFAAAFPQATILVTGVEDPGTQAHSVNESLHLGVLERAA
TAEALLLAKLAAIPTGRAEA"
gene complement(2839538..2839930)
/gene="acpS"
/locus_tag="Rv2523c"
CDS complement(2839538..2839930)
/codon_start=1
/transl_table=11
/gene="acpS"
/locus_tag="Rv2523c"
/product="holo-[acyl-carrier protein] synthase AcpS
(holo-ACP synthase)
(CoA:APO-[ACP]pantetheinephosphotransferase)
(CoA:APO-[acyl-carrier
protein]pantetheinephosphotransferase)"
/note="Rv2523c, (MT2599, MTV009.08c), len: 130 aa.
AcpS,holo-[Acyl Carrier Protein] synthase (see citation
below),equivalent to Q9X7E3|ACPS_MYCLE|ML1192|MLCB458.07
holo-[acyl-carrier protein] synthase from Mycobacterium
leprae (130 aa), FASTA scores: opt: 732, E():
5.5e-42,(87.5% identity in 128 aa overlap). Also similar
to others e.g. O86785|ACPS_STRCO|SC6G4.22c from
Streptomyces coelicolor (123 aa), FASTA scores: opt: 204,
E(): 6.6e-07,(36.7% identity in 139 aa overlap);
Q9KPB6|VC2457 from Vibrio cholerae (126 aa), FASTA scores:
opt: 163, E(): 0.00036, (32.55% identity in 129 aa
overlap); P24224|ACPS_ECOLI|DPJ|B2563 from Escherichia
coli strain K12 (125 aa), FASTA scores: opt: 151, E():
0.0022, (30.55% identity in 131 aa overlap); etc. Belongs
to the ACPS family. Acts on fas-I enzymes in C. glutamicum
(See Chalut et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv2523c"
/db_xref="EnsemblGenomes-Tr:CCP45317"
/db_xref="GOA:P9WQD3"
/db_xref="InterPro:IPR002582"
/db_xref="InterPro:IPR004568"
/db_xref="InterPro:IPR008278"
/db_xref="InterPro:IPR037143"
/db_xref="PDB:3H7Q"
/db_xref="PDB:3HQJ"
/db_xref="PDB:3NE1"
/db_xref="PDB:3NE3"
/db_xref="PDB:4HC6"
/db_xref="UniProtKB/Swiss-Prot:P9WQD3"
/protein_id="CCP45317.1"
/translation="MGIVGVGIDLVSIPDFAEQVDQPGTVFAETFTPGERRDASDKSS
SAARHLAARWAAKEAVIKAWSGSRFAQRPVLPEDIHRDIEVVTDMWGRPRVRLTGAIA
EYLADVTIHVSLTHEGDTAAAVAILEAP"
gene complement(2840123..2849332)
/gene="fas"
/locus_tag="Rv2524c"
CDS complement(2840123..2849332)
/codon_start=1
/transl_table=11
/gene="fas"
/locus_tag="Rv2524c"
/product="Probable fatty acid synthase Fas (fatty acid
synthetase)"
/note="Rv2524c, (MTCY159.32, MTV009.09c), len: 3069 aa.
Probable fas, Fatty Acid Synthase, equivalent to
Q9X7E2|fas|ML1191 putative type I fatty acid synthase from
Mycobacterium leprae (3076 aa), FASTA scores: opt:
17484,E(): 0, (85.8% identity in 3081 aa overlap). Also
similar to others e.g. Q04846|fas|Q59497 from
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
(3104 aa), FASTA scores: opt: 3981, E(): 5.5e-203, (49.8%
identity in 3099 aa overlap); Q48926|fas from
Mycobacterium bovis (2796 aa),FASTA scores: opt: 2098,
E(): 3.9e-103, (59.7% identity in 2862 aa overlap) (see
Fernandes et al., 1996); P34731|FAS1_CANAL fatty acid
synthase subunit beta from Candida albicans (Yeast) (2037
aa), FASTA scores: opt: 955,E(): 1.3e-42, (27.4% identity
in 1926 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop), and PS00606 Beta-ketoacyl synthases
active site."
/db_xref="EnsemblGenomes-Gn:Rv2524c"
/db_xref="EnsemblGenomes-Tr:CCP45318"
/db_xref="GOA:P95029"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR002539"
/db_xref="InterPro:IPR003965"
/db_xref="InterPro:IPR013565"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P95029"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45318.1"
/translation="MTIHEHDRVSADRGGDSPHTTHALVDRLMAGEPYAVAFGGQGSA
WLETLEELVSATGIETELATLVGEAELLLDPVTDELIVVRPIGFEPLQWVRALAAEDP
VPSDKHLTSAAVSVPGVLLTQIAATRALARQGMDLVATPPVAMAGHSQGVLAVEALKA
GGARDVELFALAQLIGAAGTLVARRRGISVLGDRPPMVSVTNADPERIGRLLDEFAQD
VRTVLPPVLSIRNGRRAVVITGTPEQLSRFELYCRQISEKEEADRKNKVRGGDVFSPV
FEPVQVEVGFHTPRLSDGIDIVAGWAEKAGLDVALARELADAILIRKVDWVDEITRVH
AAGARWILDLGPGDILTRLTAPVIRGLGIGIVPAATRGGQRNLFTVGATPEVARAWSS
YAPTVVRLPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAAANAGHWAELAGG
GQVTEEIFGNRIEQMAGLLEPGRTYQFNALFLDPYLWKLQVGGKRLVQKARQSGAAID
GVVISAGIPDLDEAVELIDELGDIGISHVVFKPGTIEQIRSVIRIATEVPTKPVIMHV
EGGRAGGHHSWEDLDDLLLATYSELRSRANITVCVGGGIGTPRRAAEYLSGRWAQAYG
FPLMPIDGILVGTAAMATKESTTSPSVKRMLVDTQGTDQWISAGKAQGGMASSRSQLG
ADIHEIDNSASRCGRLLDEVAGDAEAVAERRDEIIAAMAKTAKPYFGDVADMTYLQWL
RRYVELAIGEGNSTADTASVGSPWLADTWRDRFEQMLQRAEARLHPQDFGPIQTLFTD
AGLLDNPQQAIAALLARYPDAETVQLHPADVPFFVTLCKTLGKPVNFVPVIDQDVRRW
WRSDSLWQAHDARYDADAVCIIPGTASVAGITRMDEPVGELLDRFEQAAIDEVLGAGV
EPKDVASRRLGRADVAGPLAVVLDAPDVRWAGRTVTNPVHRIADPAEWQVHDGPENPR
ATHSSTGARLQTHGDDVALSVPVSGTWVDIRFTLPANTVDGGTPVIATEDATSAMRTV
LAIAAGVDSPEFLPAVANGTATLTVDWHPERVADHTGVTATFGEPLAPSLTNVPDALV
GPCWPAVFAAIGSAVTDTGEPVVEGLLSLVHLDHAARVVGQLPTVPAQLTVTATAANA
TDTDMGRVVPVSVVVTGADGAVIATLEERFAILGRTGSAELADPARAGGAVSANATDT
PRRRRRDVTITAPVDMRPFAVVSGDHNPIHTDRAAALLAGLESPIVHGMWLSAAAQHA
VTATDGQARPPARLVGWTARFLGMVRPGDEVDFRVERVGIDQGAEIVDVAARVGSDLV
MSASARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDTADKFTRDTLGFSVLH
VVRDNPTSIIASGVHYHHPDGVLYLTQFTQVAMATVAAAQVAEMREQGAFVEGAIACG
HSVGEYTALACVTGIYQLEALLEMVFHRGSKMHDIVPRDELGRSNYRLAAIRPSQIDL
DDADVPAFVAGIAESTGEFLEIVNFNLRGSQYAIAGTVRGLEALEAEVERRRELTGGR
RSFILVPGIDVPFHSRVLRVGVAEFRRSLDRVMPRDADPDLIIGRYIPNLVPRLFTLD
RDFIQEIRDLVPAEPLDEILADYDTWLRERPREMARTVFIELLAWQFASPVRWIETQD
LLFIEEAAGGLGVERFVEIGVKSSPTVAGLATNTLKLPEYAHSTVEVLNAERDAAVLF
ATDTDPEPEPEEDEPVAESPAPDVVSEAAPVAPAASSAGPRPDDLVFDAADATLALIA
LSAKMRIDQIEELDSIESITDGASSRRNQLLVDLGSELNLGAIDGAAESDLAGLRSQV
TKLARTYKPYGPVLSDAINDQLRTVLGPSGKRPGAIAERVKKTWELGEGWAKHVTVEV
ALGTREGSSVRGGAMGHLHEGALADAASVDKVIDAAVASVAARQGVSVALPSAGSGGG
ATIDAAALSEFTDQITGREGVLASAARLVLGQLGLDDPVNALPAAPDSELIDLVTAEL
GADWPRLVAPVFDPKKAVVFDDRWASAREDLVKLWLTDEGDIDADWPRLAERFEGAGH
VVATQATWWQGKSLAAGRQIHASLYGRIAAGAENPEPGRYGGEVAVVTGASKGSIAAS
VVARLLDGGATVIATTSKLDEERLAFYRTLYRDHARYGAALWLVAANMASYSDVDALV
EWIGTEQTESLGPQSIHIKDAQTPTLLFPFAAPRVVGDLSEAGSRAEMEMKVLLWAVQ
RLIGGLSTIGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSW
AARVSLAHALIGWTRGTGLMGHNDAIVAAVEEAGVTTYSTDEMAALLLDLCDAESKVA
AARSPIKADLTGGLAEANLDMAELAAKAREQMSAAAAVDEDAEAPGAIAALPSPPRGF
TPAPPPQWDDLDVDPADLVVIVGGAEIGPYGSSRTRFEMEVENELSAAGVLELAWTTG
LIRWEDDPQPGWYDTESGEMVDESELVQRYHDAVVQRVGIREFVDDGAIDPDHASPLL
VSVFLEKDFAFVVSSEADARAFVEFDPEHTVIRPVPDSTDWQVIRKAGTEIRVPRKTK
LSRVVGGQIPTGFDPTVWGISADMAGSIDRLAVWNMVATVDAFLSSGFSPAEVMRYVH
PSLVANTQGTGMGGGTSMQTMYHGNLLGRNKPNDIFQEVLPNIIAAHVVQSYVGSYGA
MIHPVAACATAAVSVEEGVDKIRLGKAQLVVAGGLDDLTLEGIIGFGDMAATADTSMM
CGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLARGDLALRMGLPVLAVVAFAQSFGDG
VHTSIPAPGLGALGAGRGGKDSPLARALAKLGVAADDVAVISKHDTSTLANDPNETEL
HERLADALGRSEGAPLFVVSQKSLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCV
DDELAGSAHFVWVRDTLRLGGKFPLKAGMLTSLGFGHVSGLVALVHPQAFIASLDPAQ
RADYQRRADARLLAGQRRLASAIAGGAPMYQRPGDRRFDHHAPERPQEASMLLNPAAR
LGDGEAYIG"
gene complement(2849852..2850574)
/locus_tag="Rv2525c"
CDS complement(2849852..2850574)
/codon_start=1
/transl_table=11
/locus_tag="Rv2525c"
/product="Conserved hypothetical protein. Secreted;
predicted to be a substrate of the twin arginine
translocation (tat) export system."
/note="Rv2525c, (MTCY159.31), len: 240 aa. Conserved
hypothetical protein, equivalent to
Q9X7E1|ML1190|MLCB458.05 hypothetical 25.3 KDA protein
from Mycobacterium leprae (239 aa), FASTA scores: opt:
1358,E(): 1e-75, (82.15% identity in 241 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004). Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2525c"
/db_xref="EnsemblGenomes-Tr:CCP45319"
/db_xref="GOA:I6XEI5"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR015020"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR019546"
/db_xref="PDB:4PMN"
/db_xref="PDB:4PMO"
/db_xref="PDB:4PMQ"
/db_xref="PDB:4PMR"
/db_xref="UniProtKB/Swiss-Prot:I6XEI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45319.1"
/translation="MSVSRRDVLKFAAATPGVLGLGVVASSLRAAPASAGSLGTLLDY
AAGVIPASQIRAAGAVGAIRYVSDRRPGGAWMLGKPIQLSEARDLSGNGLKIVSCYQY
GKGSTADWLGGASAGVQHARRGSELHAAAGGPTSAPIYASIDDNPSYEQYKNQIVPYL
RSWESVIGHQRTGVYANSKTIDWAVNDGLGSYFWQHNWGSPKGYTHPAAHLHQVEIDK
RKVGGVGVDVNQILKPQFGQWA"
gene 2851091..2851318
/gene="vapB17"
/locus_tag="Rv2526"
CDS 2851091..2851318
/codon_start=1
/transl_table=11
/gene="vapB17"
/locus_tag="Rv2526"
/product="Possible antitoxin VapB17"
/note="Rv2526, (MTCY159.30c), len: 75 aa. Possible
vapB17,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2527 (See Arcus et al., 2005; Pandey and Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2526"
/db_xref="EnsemblGenomes-Tr:CCP45320"
/db_xref="InterPro:IPR019239"
/db_xref="UniProtKB/Swiss-Prot:P9WJ49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45320.1"
/translation="MTVKRTTIELDEDLVRAAQAVTGETLRATVERALQQLVAAAAEQ
AAARRRRIVDHLAHAGTHVDADVLLSEQAWR"
gene 2851315..2851716
/gene="vapC17"
/locus_tag="Rv2527"
CDS 2851315..2851716
/codon_start=1
/transl_table=11
/gene="vapC17"
/locus_tag="Rv2527"
/product="Possible toxin VapC17"
/note="Rv2527, (MTCY159.29c), len: 133 aa. Possible
vapC17,toxin, part of toxin-antitoxin (TA) operon with
Rv2526,contains PIN domain (See Arcus et al., 2005; Pandey
and Gerdes, 2005). Similar to others in Mycobacterium
tuberculosis e.g. P95007|MTCY159.10c|Rv2546 (137 aa),
FASTA scores: opt: 206, E(): 1.4e-07, (38.0% identity in
100 aa overlap); O33299|MTV002.22c|Rv2757c (138 aa), FASTA
scores: opt: 201, E(): 3.1e-07, (35.7% identity in 126 aa
overlap); and P96411|MTCY08D5.24c|Rv0229c (226 aa), FASTA
scores: opt: 153, E(): 0.0011, (32.8% identity in 128 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2527"
/db_xref="EnsemblGenomes-Tr:CCP45321"
/db_xref="GOA:P9WF95"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF95"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45321.1"
/translation="MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSAR
SATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALH
HRAGVLHHDRDYKRIAVVRPGFQACELSRGR"
gene complement(2851751..2852671)
/gene="mrr"
/locus_tag="Rv2528c"
CDS complement(2851751..2852671)
/codon_start=1
/transl_table=11
/gene="mrr"
/locus_tag="Rv2528c"
/product="Probable restriction system protein Mrr"
/note="Rv2528c, (MTCY159.28), len: 306 aa. Probable
mrr,restriction system protein, similar to other mrr
proteins e.g. Q9RWS8|DR0587|MRR from Deinococcus
radiodurans (306 aa), FASTA scores: opt: 776, E():
4.2e-40, (40.45% identity in 309 aa overlap);
P24202|MRR_ECOLI|B4351 from Escherichia coli strain K12
(304 aa), FASTA scores: opt: 647, E(): 2.9e-32, (35.25%
identity in 309 aa overlap); Q9RX07|DR0508 from
Deinococcus radiodurans (336 aa), FASTA scores: opt: 456,
E(): 1.3e-20, (37.3% identity in 319 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2528c"
/db_xref="EnsemblGenomes-Tr:CCP45322"
/db_xref="GOA:I6Y9K2"
/db_xref="InterPro:IPR007560"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR025745"
/db_xref="UniProtKB/TrEMBL:I6Y9K2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45322.1"
/translation="MTIPDAQTLMRPILAYLADGQAKSAKDVIAAMSDEFGLSDDERA
QMLPSGRQRTMYDRVHWSLTHMSQAGLLDRPTRGHVQVTDTGRQVLKAHPERVDMAVL
REFPSYIAFRERTKAKQPVDATAKRPSGDDVQVSPEDLIDAALAENRAAVEGEILKKA
LTLSPTGFEDLVIRLLEAMGYGRAGAVERTSASGDAGIDGIISQDPLGLDRIYVQAKR
YAVDQTIGRPKIHEFAGALLGKQGDRGVYITTSSFSRGAREEAERINARIELIDGARL
AELLVRYRVGVQAVQTVELLRLDEDFFDGL"
gene 2852875..2854266
/locus_tag="Rv2529"
CDS 2852875..2854266
/codon_start=1
/transl_table=11
/locus_tag="Rv2529"
/product="Hypothetical protein"
/note="Rv2529, (MTCY159.27c), len: 463 aa. Hypothetical
unknown protein. Note that C-terminal part is similar to
short region of Q53609|MTS1_STRAL|SALIM modification
methylase SALI from Streptomyces albus G (587 aa), FASTA
scores: opt: 170, E(): 0.016, (59.45% identity in 37 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2529"
/db_xref="EnsemblGenomes-Tr:CCP45323"
/db_xref="GOA:P95024"
/db_xref="InterPro:IPR006166"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR024412"
/db_xref="InterPro:IPR042254"
/db_xref="UniProtKB/TrEMBL:P95024"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45323.1"
/translation="MHLAHRVASSRDTPSSSATPNAVSGSASNAADRPCLVRPPTAPP
WAHGPRLRRDPTGGGSTPSIVLSRSTDRSKDGHRIVPAGARKSGVRASTGRLPSTRKT
TRSPDCRPSASRTAFGTVTCPFDVTMGSSECLLHRCRTPPVPSHSVELLVAANPAEDS
RLPYLIRLPVGAGLVFATSDVWPRTKALYCHRLDIADWPADPVVVDRVELRSCSRRGA
AIDVVAARARENRSQLVHTMARGRQVVFWQSPKTRKQSRPGVRTPTARAAGIPELHIV
VDAHERYPYTFADKPAKTTREALPCGDYGLKVAGQLVAAVERKALADLTSGVLNGNLK
YQLTELAALPRAAVVVEDRYSEIFAHSFARPTAIADGLAELQIGFPNVPIVFCQTRKL
AQEYTYRYLAAALTWFVDDADATTVFEPAAAEPEPSSAELRAWAKSVGLPVSDRGRLR
PQILQAWRAAHPR"
gene complement(2854267..2854686)
/gene="vapC39"
/locus_tag="Rv2530c"
CDS complement(2854267..2854686)
/codon_start=1
/transl_table=11
/gene="vapC39"
/locus_tag="Rv2530c"
/product="Possible toxin VapC39. Contains PIN domain."
/note="Rv2530c, (MTCY159.26), len: 139 aa. Possible
vapC39,toxin, part of toxin-antitoxin (TA) operon with
Rv2530A,contains PIN domain, see Arcus et al. 2005. Highly
similar to others in Mycobacterium tuberculosis e.g.
O53219|Rv2494|MTV008.50 (141 aa), FASTA scores: opt:
380,E(): 3.6e-19, (48.0% identity in 125 aa overlap); and
O53372|Rv3320c|MTV016.20c (142 aa), FASTA scores: opt:
286,E(): 9.3e-13, (41.35% identity in 133 aa overlap); and
similar to others e.g. O07760|Rv0617|MTCY19H5.04c (133
aa),FASTA scores: opt: 158, E(): 0.00048, (39.55% identity
in 129 aa overlap). Also some similarity with
CAC48798|SMB20412 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB
(54 aa), FASTA scores: opt: 184, E(): 3.7e-06, (53.85%
identity in 52 aa overlap); and CAC48797|SMB20411
conserved hypothetical protein from Rhizobium meliloti
(Sinorhizobium meliloti) plasmid pSymB (82 aa), FASTA
scores: opt: 170,E(): 4.8e-05, (44.45% identity in 63 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2530c"
/db_xref="EnsemblGenomes-Tr:CCP45324"
/db_xref="GOA:P9WF63"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF63"
/protein_id="CCP45324.1"
/translation="MTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEA
GYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTFWPDDVPLIVGSAGDRDAVSNHR
RVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL"
gene complement(2854683..2854907)
/gene="vapB39"
/locus_tag="Rv2530A"
CDS complement(2854683..2854907)
/codon_start=1
/transl_table=11
/gene="vapB39"
/locus_tag="Rv2530A"
/product="Possible antitoxin VapB39"
/note="Rv2530A, len: 74 aa. Possible vapB39,
antitoxin,part of toxin-antitoxin (TA) operon with
Rv2530c, see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis e.g. O53218|Rv2493 (73 aa),
FASTA scores: opt: 240, E(): 5.7e-11, (56.75% identity in
74 aa overlap); and Q92WE1|RB0399|SMB20413 hypothetical
protein from Rhizobium meliloti (Sinorhizobium meliloti)p
lasmid pSymB (megaplasmid 2) (75 aa), FASTA scores: opt:
226, E(): 6.5e-10, (56.00% identity in 75 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2530A"
/db_xref="EnsemblGenomes-Tr:CCP45325"
/db_xref="GOA:P9WJ23"
/db_xref="UniProtKB/Swiss-Prot:P9WJ23"
/protein_id="CCP45325.1"
/translation="MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIV
EVDGFPVFDVPPDAPTVTSEDVVRALEDDV"
gene complement(2854938..2857781)
/gene_synonym="adi"
/locus_tag="Rv2531c"
CDS complement(2854938..2857781)
/codon_start=1
/transl_table=11
/gene_synonym="adi"
/locus_tag="Rv2531c"
/product="Probable amino acid decarboxylase"
/note="Rv2531c, (MTCY159.25), len: 947 aa. Probable amino
acid decarboxylase, equivalent to Q9CCR8|adi|ML0524
putative amino acid decarboxylase from Mycobacterium
leprae (950 aa), FASTA scores: opt: 5426, E(): 0, (86.45%
identity in 951 aa overlap). Also similar to other amino
acid decarboxylases (but longer in N-terminus) e.g.
Q9I2S7|PA1818 probable ORN/ARG/LYS amino acid
decarboxylase from Pseudomonas aeruginosa (751 aa), FASTA
scores: opt: 434, E(): 2.5e-19, (29.15% identity in 738 aa
overlap); Q9CML3|SPEF|PM0806 ornithine decarboxylase from
Pasteurella multocida (720 aa), FASTA scores: opt: 402,
E(): 2.4e-17,(24.85% identity in 752 aa overlap);
P21169|DCOR_ECOLI|spec|B2965|BAB37264|ECS3841|AAG58096
ornithine decarboxylase isozyme (constitutive enzyme) from
Escherichia coli strain K12 (711 aa), FASTA scores: opt:
396, E(): 5.6e-17, (28.0% identity in 646 aa overlap);
P44317|DCOR_HAEIN|SPEF|HI0591 ornithine decarboxylase from
Haemophilus influenzae (720 aa), FASTA scores: opt:
393,E(): 8.8e-17, (25.05% identity in 743 aa overlap) ;
etc. Seems to belong to family 1 of ornithine, lysine, and
arginine decarboxylases. Note that previously known as
adi."
/db_xref="EnsemblGenomes-Gn:Rv2531c"
/db_xref="EnsemblGenomes-Tr:CCP45326"
/db_xref="GOA:I6X4K0"
/db_xref="InterPro:IPR000310"
/db_xref="InterPro:IPR008286"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR036633"
/db_xref="UniProtKB/TrEMBL:I6X4K0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45326.1"
/translation="MNPNSVRPRRLHVSALAAVANPSYTRLDTWNLLDDACRHLAEVD
LAGLDTTHDVARAKRLMDRIGAYERYWLYPGAQNLATFRAHLDSHSTVRLTEEVSLAV
RLLSEYGDRTALFDTSASLAEQELVAQAKQQQFYTVLLADDSPATAPDSLAECLRQLR
NPADEVQFELLVVASIEDAITAVALNGEIQAAIIRHDLPLRSRDRVPLMTTLLGTDGD
EAVANETHDWVECAEWIRELRPHIDLYLLTDESIAAETQDEPDVYDRTFYRLNDVTDL
HSTVLAGLRNRYATPFFDALRAYAAAPVGQFHALPVARGASIFNSKSLHDMGEFYGRN
IFMAETSTTSGGLDSLLDPHGNIKTAMDKAAVTWNANQTYFVTNGTSTANKIVVQALT
RPGDIVLIDRNCHKSHHYGLVLAGAYPMYLDAYPLPQYAIYGAVPLRTIKQALLDLEA
AGQLHRVRMLLLTNCTFDGVVYNPRRVMEEVLAIKPDICFLWDEAWYAFATAVPWARQ
RTAMIAAERLEQMLSTAEYAEEYRNWCASMDGVDRSEWVDHRLLPDPNRARVRVYATH
STHKSLSALRQASMIHVRDQDFKALTRDAFGEAFLTHTSTSPNQQLLASLDLARRQVD
IEGFELVRHVYNMALVFRHRVRKDRLISKWFRILDESDLVPDAFRSSTVSSYRQVRQG
ALADWNEAWRSDQFVLDPTRLTLFIGATGMNGYDFREKILMERFGIQINKTSINSVLL
IFTIGVTWSSVHYLLDVLRRVAIDLDRSQKAASGADLALHRRHVEEITQDLPHLPDFS
EFDLAFRPDDASSFGDMRSAFYAGYEEADREYVQIGLAGRRLAEGKTLVSTTFVVPYP
PGFPVLVPGQLVSKEIIYFLAQLDVKEIHGYNPDLGLSVFTQAALARMEAARNAVATV
GAALPAFEVPRDASALNGTVNGDSVLQGVAEDA"
gene complement(2857853..2858254)
/locus_tag="Rv2532c"
CDS complement(2857853..2858254)
/codon_start=1
/transl_table=11
/locus_tag="Rv2532c"
/product="Hypothetical protein"
/note="Rv2532c, (MTCY159.24), len: 133 aa. Hypothetical
unknown protein, equivalent to AAK46918 from Mycobacterium
tuberculosis strain CDC1551 but shorter 157 aa."
/db_xref="EnsemblGenomes-Gn:Rv2532c"
/db_xref="EnsemblGenomes-Tr:CCP45327"
/db_xref="GOA:P95021"
/db_xref="UniProtKB/TrEMBL:P95021"
/protein_id="CCP45327.1"
/translation="MTRLELRVVVAAVLAATVVLGAVVCAAYGLTIVASAMSIYALGV
GAWLYHAIERLILARRISTVRTAAKPLQPLLPVMAAIMGLTQAVVRSLGDVTDLPARR
RELSQLPVLRWVDNSGNRANRRIADSDDLAD"
gene complement(2858254..2858724)
/gene="nusB"
/locus_tag="Rv2533c"
CDS complement(2858254..2858724)
/codon_start=1
/transl_table=11
/gene="nusB"
/locus_tag="Rv2533c"
/product="N utilization substance protein NusB (NusB
protein)"
/note="Rv2533c, (MT2608, MTCY159.23), len: 156 aa. NusB, N
utilization substance protein (see citations
below),equivalent to Q9CCR9|NUSB_MYCLE|ML0523 N
utilization substance protein B from Mycobacterium leprae
(190 aa),FASTA scores: opt: 749, E(): 2.6e-41, (75.7%
identity in 148 aa overlap). Also highly similar to others
e.g. Q9KXR0|SC9C5.14 from Streptomyces coelicolor (142
aa),FASTA scores: opt: 358, E(): 2.7e-16, (45.0% identity
in 140 aa overlap); P54520|NUSB_BACSU from Bacillus
subtilis (131 aa), FASTA scores: opt: 315, E(): 1.5e-13,
(39.55% identity in 129 aa overlap);
O83979|NUSB_TREPA|TP1015 from Treponema pallidum (141 aa),
FASTA scores: opt: 268, E(): 1.6e-10, (36.95% identity in
138 aa overlap); etc. Belongs to the NusB family."
/db_xref="EnsemblGenomes-Gn:Rv2533c"
/db_xref="EnsemblGenomes-Tr:CCP45328"
/db_xref="GOA:P9WIV1"
/db_xref="InterPro:IPR006027"
/db_xref="InterPro:IPR011605"
/db_xref="InterPro:IPR035926"
/db_xref="PDB:1EYV"
/db_xref="UniProtKB/Swiss-Prot:P9WIV1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45328.1"
/translation="MSDRKPVRGRHQARKRAVALLFEAEVRGISAAEVVDTRAALAEA
KPDIARLHPYTAAVARGVSEHAAHIDDLITAHLRGWTLDRLPAVDRAILRVSVWELLH
AADVPEPVVVDEAVQLAKELSTDDSPGFVNGVLGQVMLVTPQLRAAAQAVRGGA"
gene complement(2858727..2859290)
/gene="efp"
/locus_tag="Rv2534c"
CDS complement(2858727..2859290)
/codon_start=1
/transl_table=11
/gene="efp"
/locus_tag="Rv2534c"
/product="Probable elongation factor P Efp"
/note="Rv2534c, (MTCY159.22), len: 187 aa. Probable
efp,elongation factor P, equivalent to Q9CCS0|EFP|ML0522
elongation factor P from Mycobacterium leprae (187
aa),FASTA scores: opt: 1158, E(): 2.1e-67, (94.1% identity
in 186 aa overlap). Also highly similar to many e.g.
Q45288|EFP_CORGL from Corynebacterium glutamicum
(Brevibacterium flavum) (187 aa), FASTA scores: opt:
843,E(): 3.4e-47, (69.5% identity in 187 aa overlap);
Q9KXQ9|EFP from Streptomyces coelicolor (188 aa), FASTA
scores: opt: 833, E(): 1.5e-46, (67.0% identity in 188 aa
overlap); P49778|EFP_BACSU from Bacillus subtilis (185
aa),FASTA scores: opt: 607, E(): 4.6e-32, (47.8% identity
in 182 aa overlap); P33398|EFP_ECOLI|B4147 from
Escherichia coli strain K12 (187 aa), FASTA scores: opt:
503, E(): 1.8e-27, (42.3% identity in 182 aa overlap);
etc. Belongs to the elongation factor P family."
/db_xref="EnsemblGenomes-Gn:Rv2534c"
/db_xref="EnsemblGenomes-Tr:CCP45329"
/db_xref="GOA:P9WNM3"
/db_xref="InterPro:IPR001059"
/db_xref="InterPro:IPR008991"
/db_xref="InterPro:IPR011768"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR013185"
/db_xref="InterPro:IPR013852"
/db_xref="InterPro:IPR014722"
/db_xref="InterPro:IPR015365"
/db_xref="InterPro:IPR020599"
/db_xref="UniProtKB/Swiss-Prot:P9WNM3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45329.1"
/translation="MATTADFKNGLVLVIDGQLWTITEFQHVKPGKGPAFVRTKLKNV
LSGKVVDKTFNAGVKVDTATVDRRDTTYLYRDGSDFVFMDSQDYEQHPLPEALVGDAA
RFLLEGMPVQVAFHNGVPLYIELPVTVELEVTHTEPGLQGDRSSAGTKPATLQTGAQI
NVPLFINTGDKLKVDSRDGSYLGRVNA"
gene complement(2859300..2860418)
/gene="pepQ"
/locus_tag="Rv2535c"
CDS complement(2859300..2860418)
/codon_start=1
/transl_table=11
/gene="pepQ"
/locus_tag="Rv2535c"
/product="Probable cytoplasmic peptidase PepQ"
/note="Rv2535c, (MTCY159.21), len: 372 aa. Probable
pepQ,cytoplasmic peptidase, equivalent to
Q9CCS1|PEPQ|ML0521 putative cytoplasmic peptidase from
Mycobacterium leprae (376 aa), FASTA scores: opt: 1954,
E(): 1.1e-105, (82.7% identity in 376 aa overlap). Also
similar to other peptidases e.g. P54518|YQHT_BACSU
putative peptidase (belongs to peptidase family M24B) from
Bacillus subtilis (353 aa), FASTA scores: opt: 808, E():
1.6e-39, (39.65% identity in 368 aa overlap);
Q9KXQ8|SC9C5.16c putative peptidase from Streptomyces
coelicolor (368 aa), FASTA scores: opt: 803, E(): 3.2e-39,
(43.15% identity in 380 aa overlap); Q9K950|BH2800 XAA-pro
dipeptidase from Bacillus halodurans (355 aa), FASTA
scores: opt: 801, E(): 4.1e-39,(39.45% identity in 365 aa
overlap); etc. Note that second part of protein is similar
to second part of MTCY49.29c|Rv2089c|MT2150|MTCY49.29c
probable dipeptidase; belongs to peptidase family M24B
from Mycobacterium tuberculosis (375 aa) (33.9% identity
in 354 aa overlap) blast results: Score: 142 bits (359),
E: 4e-33, Identities: 86/224 (38%), Positives: 119/224
(52%), Gaps: 4/224 (1%). Could be belong to peptidase
family M24B. Conserved in M. tuberculosis, M. leprae, M.
bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2535c"
/db_xref="EnsemblGenomes-Tr:CCP45330"
/db_xref="GOA:I6YDN6"
/db_xref="InterPro:IPR000587"
/db_xref="InterPro:IPR000994"
/db_xref="InterPro:IPR001131"
/db_xref="InterPro:IPR001714"
/db_xref="InterPro:IPR029149"
/db_xref="InterPro:IPR036005"
/db_xref="UniProtKB/TrEMBL:I6YDN6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45330.1"
/translation="MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALL
VFADERDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGRAGEAGVGKLGFESHVV
TVDGLDALAGALEGKNTELVRASGTVESLREVKDAGELALLRLACEAADAALTDLVAR
GGLRPGRTERQVSRELEALMLDHGADAVSFETIVAAGANSAIPHHRPTDAVLQVGDFV
KIDFGALVAGYHSDMTRTFVLGKAADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAA
ARQLIADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRG
GVRIEDTLVVAGGTPKMPETAGQTPELLTRFPKELAIL"
gene 2860452..2861144
/locus_tag="Rv2536"
CDS 2860452..2861144
/codon_start=1
/transl_table=11
/locus_tag="Rv2536"
/product="Probable conserved transmembrane protein"
/note="Rv2536, (MTCY159.20c), len: 230 aa. Probable
conserved transmembrane protein, equivalent to
Q9CCS2|ML0520 putative membrane protein from Mycobacterium
leprae (202 aa), FASTA scores: opt: 812, E(): 2e-41,
(63.2% identity in 201 aa overlap). Also similar in part
to Q9HMD5|VNG2594c from Halobacterium sp. strain NRC-1
(117 aa), FASTA scores: opt: 33.6, E(): 1.8, (33.6%
identity in 116 aa overlap); and perhaps AAK65752|SMA1996
putative ABC transporter permease protein from Rhizobium
meliloti (Sinorhizobium meliloti) plasmid pSymA (323 aa),
FASTA scores: opt: 117, E(): 6.1, (30.6% identity in 121
aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2536"
/db_xref="EnsemblGenomes-Tr:CCP45331"
/db_xref="GOA:P95017"
/db_xref="UniProtKB/TrEMBL:P95017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45331.1"
/translation="MTNWMLRGLAFAAAMVVLRLFQGALINAWQMLSGLISLVLLLLF
AIGGVVWGVMDGRADAKASPDPDRRQDLAMTWLLAGLVAGALSGAVAWLISLFYKAIY
TGGPINELTTFAAFTALIVFLVGIVGVAVGRWLVDRQLAKAPVRHHGLAAEHERAADT
DVFSAVRADDSPTGEMQVAQPEAQTAAVATVEREAPTEVIRTTESDTPTEVIRTDTEA
DQTKPGDEPKKD"
gene complement(2861148..2861591)
/gene="aroD"
/gene_synonym="aroQ"
/locus_tag="Rv2537c"
CDS complement(2861148..2861591)
/codon_start=1
/transl_table=11
/gene="aroD"
/gene_synonym="aroQ"
/locus_tag="Rv2537c"
/product="3-dehydroquinate dehydratase AroD (AROQ)
(3-dehydroquinase) (type II dhqase)"
/note="Rv2537c, (MTCY159.19), len: 147 aa. AroD (alternate
gene name: aroQ), 3-dehydroquinate dehydratase (see
citation below), equivalent to Q9CCS3|AROD|ML0519
3-dehydroquinate dehydratase from Mycobacterium leprae
(145 aa), FASTA scores: opt: 803, E(): 3.4e-46, (85.9%
identity in 142 aa overlap). Also highly similar to many
e.g. P96750|AROQ_CORPS from Corynebacterium
pseudotuberculosis (146 aa), FASTA scores: opt: 559, E():
4.1e-30, (61.05% identity in 136 aa overlap);
Q9K949|BH2801 from Bacillus halodurans (145 aa), FASTA
scores: opt: 453, E(): 4e-23,(52.15% identity in 138 aa
overlap); P54517|AROQ_BACSU|YQHS from Bacillus subtilis
(148 aa), FASTA scores: opt: 419,E(): 7.1e-21, (45.3%
identity in 139 aa overlap); etc. Contains PS01029
Dehydroquinase class II signature. Belongs to the type-II
3-dehydroquinase family."
/db_xref="EnsemblGenomes-Gn:Rv2537c"
/db_xref="EnsemblGenomes-Tr:CCP45332"
/db_xref="GOA:P9WPX7"
/db_xref="InterPro:IPR001874"
/db_xref="InterPro:IPR018509"
/db_xref="InterPro:IPR036441"
/db_xref="PDB:1H05"
/db_xref="PDB:1H0R"
/db_xref="PDB:1H0S"
/db_xref="PDB:2DHQ"
/db_xref="PDB:2XB8"
/db_xref="PDB:2Y71"
/db_xref="PDB:2Y76"
/db_xref="PDB:2Y77"
/db_xref="PDB:3N59"
/db_xref="PDB:3N76"
/db_xref="PDB:3N7A"
/db_xref="PDB:3N86"
/db_xref="PDB:3N87"
/db_xref="PDB:3N8K"
/db_xref="PDB:3N8N"
/db_xref="PDB:4B6O"
/db_xref="PDB:4B6P"
/db_xref="PDB:4B6Q"
/db_xref="PDB:4CIV"
/db_xref="PDB:4CIW"
/db_xref="PDB:4CIX"
/db_xref="PDB:4CIY"
/db_xref="PDB:4CKW"
/db_xref="PDB:4CKX"
/db_xref="PDB:4CKY"
/db_xref="PDB:4CKZ"
/db_xref="PDB:4CL0"
/db_xref="PDB:4KI7"
/db_xref="PDB:4KIJ"
/db_xref="PDB:4KIU"
/db_xref="PDB:4KIW"
/db_xref="PDB:4V0S"
/db_xref="UniProtKB/Swiss-Prot:P9WPX7"
/inference="protein motif:PROSITE:PS01029"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45332.1"
/translation="MSELIVNVINGPNLGRLGRREPAVYGGTTHDELVALIEREAAEL
GLKAVVRQSDSEAQLLDWIHQAADAAEPVILNAGGLTHTSVALRDACAELSAPLIEVH
ISNVHAREEFRRHSYLSPIATGVIVGLGIQGYLLALRYLAEHVGT"
gene complement(2861588..2862676)
/gene="aroB"
/locus_tag="Rv2538c"
CDS complement(2861588..2862676)
/codon_start=1
/transl_table=11
/gene="aroB"
/locus_tag="Rv2538c"
/product="3-dehydroquinate synthase AroB"
/note="Rv2538c, (MTCY159.18), len: 362 aa.
AroB,3-dehydroquinate synthase (see citations below),
equivalent to Q9CCS4|AROB_MYCLE|ML0518 3-dehydroquinate
synthase from Mycobacterium leprae (361 aa), FASTA scores:
opt: 2059,E(): 3.3e-117, (87.25% identity in 361 aa
overlap). Also highly similar to many e.g. Q9KXQ6|AROB
from Streptomyces coelicolor (363 aa), FASTA scores: opt:
1363, E(): 4e-75,(60.05% identity in 358 aa overlap);
Q9X5D2|AROB_CORGL from Corynebacterium glutamicum
(Brevibacterium flavum) (366 aa), FASTA scores: opt: 1154,
E(): 1.7e-62, (50.95% identity in 359 aa overlap);
P07639|AROB_ECOLI|B3389 from Escherichia coli strain K12
(362 aa), FASTA scores: opt: 771, E(): 2.4e-39, (40.6%
identity in 345 aa overlap); etc. Belongs to the
dehydroquinate synthase family."
/db_xref="EnsemblGenomes-Gn:Rv2538c"
/db_xref="EnsemblGenomes-Tr:CCP45333"
/db_xref="GOA:P9WPX9"
/db_xref="InterPro:IPR016037"
/db_xref="InterPro:IPR030960"
/db_xref="InterPro:IPR030963"
/db_xref="PDB:3QBD"
/db_xref="PDB:3QBE"
/db_xref="UniProtKB/Swiss-Prot:P9WPX9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45333.1"
/translation="MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVH
QPGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGRKDALV
SLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFH
QPLAVLVDLATLQTLPRDEMICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLP
ELIRRAITVKAEVVAADEKESELREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFA
AELARLAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMAGDKKTRAGVLRFVV
LDGLAKPGRMVGPDPGLLVTAYAGVCAP"
gene complement(2862673..2863203)
/gene="aroK"
/locus_tag="Rv2539c"
CDS complement(2862673..2863203)
/codon_start=1
/transl_table=11
/gene="aroK"
/locus_tag="Rv2539c"
/product="Shikimate kinase AroK (SK)"
/note="Rv2539c, (MTCY159.17), len: 176 aa. AroK, shikimate
kinase (see citations below), equivalent to
Q9CCS5|AROK|ML0517 putative shikimate kinase from
Mycobacterium leprae (199 aa), FASTA scores: opt: 852,
E(): 1.3e-42, (79.65% identity in 167 aa overlap). Also
highly similar to many e.g. Q9X5D1|AROK_CORG from
Corynebacterium glutamicum (Brevibacterium flavum) (169
aa), FASTA scores: opt: 478, E(): 5.4e-21, (47.0% identity
in 168 aa overlap); Q9KXQ5|AROK from Streptomyces
coelicolor (171 aa), FASTA scores: opt: 465, E(): 3.1e-20,
(49.1% identity in 167 aa overlap); P24167|AROK_ECOLI from
Escherichia coli strain K12 (172 aa), FASTA scores: opt:
316, E(): 1.3e-11, (38.4% identity in 164 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A, and
PS01128 Shikimate kinase signature. Belongs to the
shikimate kinase family."
/db_xref="EnsemblGenomes-Gn:Rv2539c"
/db_xref="EnsemblGenomes-Tr:CCP45334"
/db_xref="GOA:P9WPY3"
/db_xref="InterPro:IPR000623"
/db_xref="InterPro:IPR023000"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR031322"
/db_xref="PDB:1L4U"
/db_xref="PDB:1L4Y"
/db_xref="PDB:1U8A"
/db_xref="PDB:1WE2"
/db_xref="PDB:1ZYU"
/db_xref="PDB:2DFN"
/db_xref="PDB:2DFT"
/db_xref="PDB:2G1J"
/db_xref="PDB:2G1K"
/db_xref="PDB:2IYQ"
/db_xref="PDB:2IYR"
/db_xref="PDB:2IYS"
/db_xref="PDB:2IYT"
/db_xref="PDB:2IYU"
/db_xref="PDB:2IYV"
/db_xref="PDB:2IYW"
/db_xref="PDB:2IYX"
/db_xref="PDB:2IYY"
/db_xref="PDB:2IYZ"
/db_xref="PDB:3BAF"
/db_xref="PDB:4BQS"
/db_xref="UniProtKB/Swiss-Prot:P9WPY3"
/inference="protein motif:PROSITE:PS01128"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45334.1"
/translation="MAPKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRS
IADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEI
SAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVR
HILSRLQVPSPSEAAT"
gene complement(2863207..2864412)
/gene="aroF"
/gene_synonym="aroC"
/locus_tag="Rv2540c"
CDS complement(2863207..2864412)
/codon_start=1
/transl_table=11
/gene="aroF"
/gene_synonym="aroC"
/locus_tag="Rv2540c"
/product="Probable chorismate synthase AroF
(5-enolpyruvylshikimate-3-phosphate phospholyase)"
/note="Rv2540c, (MTCY159.16), len: 401 aa. Probable aroF
(alternate gene name: aroC), chorismate
synthase,equivalent to Q9CCS6|AROF|ML0516 putative
chorismate synthase from Mycobacterium leprae (407 aa),
FASTA scores: opt: 2278, E(): 6.2e-123, (88.05% identity
in 401 aa overlap). Also highly similar to many e.g.
Q9X5D0|AROC_CORGL from Corynebacterium glutamicum
(Brevibacterium flavum) (410 aa), FASTA scores: opt:
1811,E(): 3e-96, (70.3% identity in 397 aa overlap);
Q9KXQ4|AROC_STRCO|AROF|SC9C5.20c from Streptomyces
coelicolor (394 aa), FASTA scores: opt: 1710, E():
1.7e-90,(67.0% identity in 385 aa overlap);
Q9KCB7|AROC_BACHD|AROF|BH1656 from Bacillus halodurans
(390 aa), FASTA scores: opt: 1196, E(): 3.9e-61, (48.7%
identity in 386 aa overlap); etc. Contains PS00788
Chorismate synthase signature 2. Belongs to the chorismate
synthase family. Cofactor: reduced flavin, NADH"
/db_xref="EnsemblGenomes-Gn:Rv2540c"
/db_xref="EnsemblGenomes-Tr:CCP45335"
/db_xref="GOA:P9WPY1"
/db_xref="InterPro:IPR000453"
/db_xref="InterPro:IPR020541"
/db_xref="InterPro:IPR035904"
/db_xref="PDB:1ZTB"
/db_xref="PDB:2G85"
/db_xref="PDB:2O11"
/db_xref="PDB:2O12"
/db_xref="PDB:2QHF"
/db_xref="PDB:4BAI"
/db_xref="PDB:4BAJ"
/db_xref="UniProtKB/Swiss-Prot:P9WPY1"
/inference="protein motif:PROSITE:PS00788"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45335.1"
/translation="MLRWITAGESHGRALVAVVEGMVAGVHVTSADIADQLARRRLGY
GRGARMTFERDAVTVLSGIRHGSTLGGPIAIEIGNTEWPKWETVMAADPVDPAELADV
ARNAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTVARAFLRQALG
VEVLSHVISIGASAPYEGPPPRAEDLPAIDASPVRAYDKAAEADMIAQIEAAKKDGDT
LGGVVEAVALGLPVGLGSFTSGDHRLDSQLAAAVMGIQAIKGVEIGDGFQTARRRGSR
AHDEMYPGPDGVVRSTNRAGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDLATGDE
AVAIHQRSDVCAVPAAGVVVETMVALVLARAALEKFGGDSLAETQRNIAAYQRSVADR
EAPAARVSG"
gene 2864427..2864834
/locus_tag="Rv2541"
CDS 2864427..2864834
/codon_start=1
/transl_table=11
/locus_tag="Rv2541"
/product="Hypothetical alanine rich protein"
/note="Rv2541, (MTCY159.15c), len: 135 aa. Hypothetical
unknown ala-rich protein, equivalent to AAK46926|MT2615.1
hypothetical 38.9 KDA protein from Mycobacterium
tuberculosis strain CDC1551 but AAK46926|MT2615.1 longer
at C-terminus. Questionable ORF. Some similarity with
Rv2077A from Mycobacterium tuberculosis (99 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2541"
/db_xref="EnsemblGenomes-Tr:CCP45336"
/db_xref="UniProtKB/TrEMBL:P95012"
/protein_id="CCP45336.1"
/translation="MRRRRPPHVNAPTPCDRGDVRPPGCPASIPGVEVAGGTRARLRV
TADGLQALAGRCATLAGELSAAVAPSGAVLSWQANAVAVNAAHARAGAAAAAVSARMR
ATAAALGQAARRYAGQDTAAAAALGAVRPWGTH"
gene 2865130..2866341
/locus_tag="Rv2542"
CDS 2865130..2866341
/codon_start=1
/transl_table=11
/locus_tag="Rv2542"
/product="Conserved hypothetical protein"
/note="Rv2542, (MTCY159.14c), len: 403 aa. Conserved
hypothetical protein, highly similar to AAK46927|MT2616
hypothetical 28.0 KDA protein from Mycobacterium
tuberculosis strain CDC1551 (265 aa), FASTA scores: opt:
1776, E(): 2.3e-94, (99.25% identity in 265 aa overlap).
And similar to several hypothetical proteins from
Mycobacterium tuberculosis (strain H37Rv and CDC1551) e.g.
P71654|Rv2797c|MTCY16B7.46 (562 aa), FASTA scores: opt:
537, E(): 2.6e-23, (40.75% identity in 292 aa overlap);
P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 (266
aa),FASTA scores: opt: 357, E(): 2.6e-13, (34.6% identity
in 234 aa overlap);
Q10685|YK77_MYCTU|Rv2077c|MT2137|MTCY49.16c (323 aa),
FASTA scores: opt: 261, E(): 9.5e-08, (32.7% identity in
211 aa overlap); etc. Also similar to Q9RDQ9|SC4A7.03
putative secreted protein from Streptomyces coelicolor
(406 aa),FASTA scores: opt: 247, E(): 7.3e-07, (30.35%
identity in 303 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2542"
/db_xref="EnsemblGenomes-Tr:CCP45337"
/db_xref="GOA:P95011"
/db_xref="InterPro:IPR010427"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P95011"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45337.1"
/translation="MLDAVSDARRDGFAVGEDYTVTDRSTGGSRQQRAARLGQAQGHA
DFIRHRVGALLATDRDIATRVSAATQGLDELAFEDVPGVDTPAEDGVQAVDFRQAPPP
GAPGGMSSGDIDAIDAANRALLQDMLAEYSRLPDGQVKTDRLADIAAIQEALRVPDSH
LIYVARPDDPADMIPAVTAVGDPFTADHVSVTVPGVSGTTRQTIATMTQETRGLREEA
RVIAHSVGESENVATIAWVGYQPPPVLASWNTVDDDLAQAGAPKLEAFLRDLQAGSHN
PGHTTALFGHSYGSLLSGIALKDGASSLVDNAVLYGSPGFDATSPAKLGMNDHNFFVM
TTPDDPIRYPARLAPLHGWGSDGADTIGTVGRQGTPARVGIRPQRDHRRIPGPLPLHP
SADRRGIHSAG"
gene 2866468..2867127
/gene="lppA"
/locus_tag="Rv2543"
CDS 2866468..2867127
/codon_start=1
/transl_table=11
/gene="lppA"
/locus_tag="Rv2543"
/product="Probable conserved lipoprotein LppA"
/note="Rv2543, (MTCY159.13c), len: 219 aa. Probable
lppA,conserved lipoprotein, highly similar to upstream ORF
P95009|LPPB|Rv2544|MTCY159.12 putative lipoprotein LPPB
from Mycobacterium tuberculosis (220 aa), FASTA scores:
opt: 1240, E(): 1.1e-73, (87.15% identity in 218 aa
overlap). Contains PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2543"
/db_xref="EnsemblGenomes-Tr:CCP45338"
/db_xref="GOA:P9WK81"
/db_xref="InterPro:IPR032018"
/db_xref="PDB:2V7S"
/db_xref="UniProtKB/Swiss-Prot:P9WK81"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP45338.1"
/translation="MIAPQPISRTLPRWQRIVALTMIGISTALIGGCTMDHNPDTSRR
LTGEQKIQLIDSMRNKGSYEAARERLTATARIIADRVSAAIPGQTWKFDDDPNIQQSD
RNGALCDKLTADIARRPIANSVMFGATFSAEDFKIAANIVREEAAKYGATTESSLFNE
SAKRDYDVQGNGYEFRLLQIKFATLNITGDCFLLQKVLDLPAGQLPPEPPIWPTTSTP
H"
gene 2867124..2867786
/gene="lppB"
/locus_tag="Rv2544"
CDS 2867124..2867786
/codon_start=1
/transl_table=11
/gene="lppB"
/locus_tag="Rv2544"
/product="Probable conserved lipoprotein LppB"
/note="Rv2544, (MTCY159.12c), len: 220 aa. Probable
lppB,conserved lipoprotein, highly similar to downstream
ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 putative
lipoprotein LPPA from Mycobacterium tuberculosis (219
aa),FASTA scores: opt: 1242, E(): 4.8e-72, (87.15%
identity in 218 aa overlap). Contains PS00013 Prokaryotic
membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2544"
/db_xref="EnsemblGenomes-Tr:CCP45339"
/db_xref="GOA:P9WK79"
/db_xref="InterPro:IPR032018"
/db_xref="UniProtKB/Swiss-Prot:P9WK79"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45339.1"
/translation="MIAPQPIPRTLPRWQRIVALTMIGISTALIGGCTMGQNPDKSPH
LTGEQKIQLIDSMRHKGSYEAARERLTATAQIIADRVSAAIPGQTWKFNDDSYGQDFY
RNGSLCKELSADIARRPMAKPVDFGSTFSAEDFKIAANIVREEAAKYGVTTESSLFNE
SAKRDYDVQGNGYEFNLGQIKFATLNITGDCFLLQKVLDLPAGQLPPEPPIWPTTSTP
TP"
gene 2867783..2868061
/gene="vapB18"
/locus_tag="Rv2545"
CDS 2867783..2868061
/codon_start=1
/transl_table=11
/gene="vapB18"
/locus_tag="Rv2545"
/product="Possible antitoxin VapB18"
/note="Rv2545, (MTY159.11c), len: 92 aa. Possible
vapB18,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2546 (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Similar to others in Mycobacterium tuberculosis e.g.
O33300|Rv2758c|MTV002.23c (88 aa), FASTA scores: opt:
151,E(): 9.8e-05, (66.65% identity in 45 aa overlap); and
Q10771|Rv1560|MT1611|MTCY48.05 (72 aa), FASTA scores: opt:
84, E(): 8.2, (46.5% identity in 43 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2545"
/db_xref="EnsemblGenomes-Tr:CCP45340"
/db_xref="InterPro:IPR019239"
/db_xref="UniProtKB/Swiss-Prot:P9WJ47"
/protein_id="CCP45340.1"
/translation="MSTTIVAGVIQGHLPVILPTRRRARDLGHTTALFRAQTLQCIYL
SIEYLYVCSMSRRTTIDIDDILLARAQAALGTTGLKDRVDAALRAAVR"
gene 2868154..2868567
/gene="vapC18"
/locus_tag="Rv2546"
CDS 2868154..2868567
/codon_start=1
/transl_table=11
/gene="vapC18"
/locus_tag="Rv2546"
/product="Possible toxin VapC18"
/note="Rv2546, (MTCY159.10c), len: 137 aa. Possible
vapC18,toxin, part of toxin-antitoxin (TA) operon with
Rv2545,contains PIN domain (See Arcus et al., 2005; Pandey
and Gerdes, 2005). Similar to others in Mycobacterium
tuberculosis e.g. P96411|Rv0229c|MTCY08D5.24c (226
aa),FASTA scores: opt: 272, E(): 1.3e-11, (39.7% identity
in 136 aa overlap); O33299|Rv2757c|MTV002.22c (138 aa),
FASTA scores: opt: 265, E(): 2.5e-11, (38.5% identity in
135 aa overlap); P95026|Rv2527|MTCY159.29c (133 aa), FASTA
scores: opt: 206, E(): 2.6e-07, (38.0% identity in 100 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2546"
/db_xref="EnsemblGenomes-Tr:CCP45341"
/db_xref="GOA:P95007"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P95007"
/protein_id="CCP45341.1"
/translation="MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYS
ANSATDYDALADELDGLARIPVGAETFTRACQVQRELAHVAGLHHRSVKIADLVIAAA
AELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL"
gene 2868606..2868863
/gene="vapB19"
/locus_tag="Rv2547"
CDS 2868606..2868863
/codon_start=1
/transl_table=11
/gene="vapB19"
/locus_tag="Rv2547"
/product="Possible antitoxin VapB19"
/note="Rv2547, (MTCY159.09c), len: 85 aa. Possible
vapB19,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2548 (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Similar to others in Mycobacterium tuberculosis e.g.
P71666|YD98_MYCTU|Rv1398c|MT1442|MTCY21B4.15c hypothetical
9.4 KDA protein from (85 aa), FASTA scores: opt: 108, E():
0.33, (37.1% identity in 62 aa overlap); and to
CAC45864|SMC01933 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) (71 aa), FASTA
scores: opt: 105, E(): 0.46, (28.4% identity in 74 aa
overlap); Q97W38|SSO10342 hypothetical protein from
Sulfolobus solfataricus (58 aa), FASTA scores: opt:
94,E(): 2.3, (46.95% identity in 49 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2547"
/db_xref="EnsemblGenomes-Tr:CCP45342"
/db_xref="GOA:P95006"
/db_xref="InterPro:IPR002145"
/db_xref="InterPro:IPR010985"
/db_xref="UniProtKB/Swiss-Prot:P95006"
/protein_id="CCP45342.1"
/translation="MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQ
ERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLARLGLA"
gene 2868860..2869237
/gene="vapC19"
/locus_tag="Rv2548"
CDS 2868860..2869237
/codon_start=1
/transl_table=11
/gene="vapC19"
/locus_tag="Rv2548"
/product="Possible toxin VapC19"
/note="Rv2548, (MTCY159.08c), len: 125 aa. Possible
vapC19,toxin, part of toxin-antitoxin (TA) operon with
Rv2547,contains PIN domain (See Arcus et al., 2005; Pandey
and Gerdes, 2005). Similarity to others in Mycobacterium
tuberculosis e.g. P71665|Rv1397c|MTCY21B4.14c hypothetical
15.0 KDA protein (133 aa), FASTA scores: opt: 265, E():
7.1e-12, (42.3% identity in 123 aa overlap); and to
Q97WY5|SSO1975 hypothetical protein from Sulfolobus
solfataricus (125 aa), FASTA scores: opt: 131, E():
0.018,(30.0% identity in 110 aa overlap); O52285|YLE
hypothetical 14.9 KDA protein from Agrobacterium
radiobacter (133 aa),FASTA scores: opt: 128, E(): 0.03,
(32.8% identity in 125 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2548"
/db_xref="EnsemblGenomes-Tr:CCP45343"
/db_xref="GOA:P9WF93"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF93"
/protein_id="CCP45343.1"
/translation="MKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELL
AGVRESELAALEAFFSAVVWTLVTEDIARIGGRLARRYRSSHRGIDDVDYLIAATAIV
VDADLLTTNVRHFPMFPDLQPPY"
gene complement(2869253..2869627)
/locus_tag="Rv2548A"
CDS complement(2869253..2869627)
/codon_start=1
/transl_table=11
/locus_tag="Rv2548A"
/product="Conserved protein"
/note="Rv2548A, len: 124 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv2548A"
/db_xref="EnsemblGenomes-Tr:CCP45344"
/db_xref="UniProtKB/TrEMBL:I6XEK2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45344.1"
/translation="MLPENLEQRVTALESQVRELADRVRASEQDAAAARVLAGAADRD
VTEFVGEFRDFRRATIGSFNALREDFTALREEMTERFSHVEERFSRVDDGFTEMRGKL
DGAAAGQQRIVELIEQLIADQG"
gene complement(2869727..2870122)
/gene="vapC20"
/locus_tag="Rv2549c"
CDS complement(2869727..2870122)
/codon_start=1
/transl_table=11
/gene="vapC20"
/locus_tag="Rv2549c"
/product="Possible toxin VapC20"
/note="Rv2549c, (MTCY159.07), len: 131 aa. Possible
vapC20,toxin, part of toxin-antitoxin (TA) operon with
Rv2550c,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Conserved hypothetical protein,
showing some similarity to P73415|SLL1715 from
Synechocystis sp. strain PCC 6803 (157 aa), FASTA scores:
opt: 167, E(): 4.2e-05,(29.45% identity in 129 aa
overlap); Q9HHY6|VNG6166H from Halobacterium sp. plasmid
pNRC200 strain NRC-1 (144 aa),FASTA scores: opt: 133, E():
0.011, (29.6% identity in 125 aa overlap); and
Q9HSU3|VNG0072H from Halobacterium sp. strain NRC-1 (144
aa), FASTA scores: opt: 113, E(): 0.29,(25.75% identity in
136 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2549c"
/db_xref="EnsemblGenomes-Tr:CCP45345"
/db_xref="GOA:P95004"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="InterPro:IPR039018"
/db_xref="UniProtKB/Swiss-Prot:P95004"
/protein_id="CCP45345.1"
/translation="MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGET
WTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEEQAWEWLVRHDEREYSFVDATSF
AVMRKKGIQNAYAFDGDFSAAGFVEVRPE"
gene complement(2870119..2870364)
/gene="vapB20"
/locus_tag="Rv2550c"
CDS complement(2870119..2870364)
/codon_start=1
/transl_table=11
/gene="vapB20"
/locus_tag="Rv2550c"
/product="Possible antitoxin VapB20"
/note="Rv2550c, (MTCY159.06), len: 81 aa. Possible
vapB20,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2549c (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Some similarity to others in M. tuberculosis e.g. Rv0581"
/db_xref="EnsemblGenomes-Gn:Rv2550c"
/db_xref="EnsemblGenomes-Tr:CCP45346"
/db_xref="GOA:P9WJ45"
/db_xref="InterPro:IPR002145"
/db_xref="UniProtKB/Swiss-Prot:P9WJ45"
/protein_id="CCP45346.1"
/translation="MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVA
EHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKHE"
gene complement(2870775..2871194)
/locus_tag="Rv2551c"
CDS complement(2870775..2871194)
/codon_start=1
/transl_table=11
/locus_tag="Rv2551c"
/product="Conserved hypothetical protein"
/note="Rv2551c, (MTCY159.05), len: 139 aa. Conserved
hypothetical protein, similar to the second part of
Q9XAP1|SC10A7.34c putative type IV peptidase from
Streptomyces coelicolor (259 aa), FASTA scores: opt:
243,E(): 7.4e-08, (40.95% identity in 144 aa overlap).
Also some similarity with other proteins e.g.
AAK58497|GSPO GSPO protein from Acetobacter diazotrophicus
(261 aa), FASTA scores: opt: 152, E(): 0.025, (33.35%
identity in 135 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2551c"
/db_xref="EnsemblGenomes-Tr:CCP45347"
/db_xref="GOA:I6Y9M6"
/db_xref="InterPro:IPR000045"
/db_xref="UniProtKB/TrEMBL:I6Y9M6"
/protein_id="CCP45347.1"
/translation="MLAAAVLAWMGVLCVCDVRQRRLPNWLTLPGAGVILLFAGLAGR
GVPALAGAAALAGVYLLVHLALPAAMGAGDVKLAIGLGGLTGCFGVEVWFLAALAAPL
LTAVCGVMVTPWGVRTLPHGPSMCVASLGAVGLALLG"
gene complement(2871206..2872015)
/gene="aroE"
/locus_tag="Rv2552c"
CDS complement(2871206..2872015)
/codon_start=1
/transl_table=11
/gene="aroE"
/locus_tag="Rv2552c"
/product="Probable shikimate 5-dehydrogenase AroE
(5-dehydroshikimate reductase)"
/note="Rv2552c, (MTCY159.04), len: 269 aa. Probable
aroE,shikimate 5-dehydrogenase, equivalent to
Q9CCS7|AROE|ML0515 putative shikimate 5-dehydrogenase from
Mycobacterium leprae (278 aa), FASTA scores: opt: 1452,
E(): 1.8e-77,(81.5% identity in 270 aa overlap). Also
highly similar,but longer 101 aa, to Q9KH59|AROE putative
shikimate dehydrogenase (fragment) from Mycobacterium
marinum (148 aa), FASTA scores: opt: 729, E(): 1.3e-35,
(76.35% identity in 148 overlap); Q9F7W3|AROE from
Mycobacterium ulcerans (148 aa), FASTA scores: opt: 718,
E(): 5.9e-35, (75.7% identity in 148 aa overlap). And also
similar to to others e.g. Q9KXQ2|AROE from Streptomyces
coelicolor (255 aa),FASTA scores: opt: 572, E(): 2.8e-26,
(43.4% identity in 251 aa overlap); Q98DY3|MLR4492 from
Rhizobium loti (Mesorhizobium loti) (280 aa), FASTA
scores: opt: 385, E(): 2.2e-15, (34.85% identity in 284 aa
overlap); P74591|AROE_SYNY3|SLR1559 from Synechocystis sp.
strain PCC 6803 (290 aa), FASTA scores: opt: 347, E():
3.7e-13, (30.9% identity in 275 aa overlap);
P15770|AROE_ECOLI|B3281 from Escherichia coli strain K12
(272 aa), FASTA scores: opt: 230, E(): 7.7e-08, (29.5%
identity in 251 aa overlap); etc. Belongs to the shikimate
dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv2552c"
/db_xref="EnsemblGenomes-Tr:CCP45348"
/db_xref="GOA:I6Y120"
/db_xref="InterPro:IPR010110"
/db_xref="InterPro:IPR013708"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR041121"
/db_xref="PDB:4P4G"
/db_xref="PDB:4P4L"
/db_xref="PDB:4P4N"
/db_xref="UniProtKB/TrEMBL:I6Y120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45348.1"
/translation="MSEGPKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECG
AAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRAD
NTDIDGVAGALGAAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDL
GTRVGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPW
PTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD"
gene complement(2872012..2873265)
/locus_tag="Rv2553c"
CDS complement(2872012..2873265)
/codon_start=1
/transl_table=11
/locus_tag="Rv2553c"
/product="Probable conserved membrane protein"
/note="Rv2553c, (MTCY159.03), len: 417 aa. Probable
conserved membrane protein, equivalent to Q9CCS8|ML0514
putative membrane protein from Mycobacterium leprae (421
aa), FASTA scores: opt: 1955, E(): 1.1e-111, (72.7%
identity in 414 aa overlap). Also similar in part to
various proteins e.g. Q9L9G6|NOVB NOVB protein
(aminodesoxychorismate lyase) from Streptomyces
sphaeroides (284 aa), FASTA scores: opt: 451, E(): 2.9e-2,
(37.95% identity in 203 aa overlap); Q9EWY3|2SCG38.36
conserved hypothetical protein from Streptomyces
coelicolor (253 aa),FASTA scores: opt: 419, E(): 2.3e-18,
(39.2% identity in 171 aa overlap); Q9CHT3|YGCC
hypothetical protein from Lactococcus lactis (subsp.
lactis) (Streptococcus lactis) (550 aa), FASTA scores:
opt: 379, E(): 1.2e-15, (23.0% identity in 417 aa
overlap); O25309|HP0587 aminodeoxychorismate lyase (PABC)
from Helicobacter pylori (Campylobacter pylori) (329 aa),
FASTA scores: opt: 290,E(): 2e-10, (31.65% identity in 180
aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2553c"
/db_xref="EnsemblGenomes-Tr:CCP45349"
/db_xref="GOA:I6XEK6"
/db_xref="InterPro:IPR003770"
/db_xref="UniProtKB/TrEMBL:I6XEK6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45349.1"
/translation="MPDGGHRHRAQPVSVRPNRHRRTRVSRAQRRHAQQIRRRRRVAG
GFALSLLVVVVVVAVVVGAKLWQTMLGFGNDYTGPGKRDIVIQIRAGDSTTAVGETLL
KHGVVATVRAFVDAAHGNTAISSIQPGFYRMRTEISAASAVARLTDPHNRVGKLVIPE
GRQLDDTTDMKTNVVNPGIFALISRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVP
RWAVGPVMELGTDHRRIEGLIAPGTFNIDPSASAETILATLISAGAVEYMKSGLVDTA
KSLGLSPYDILVVASLVQQEANTQDFPKVARVIYNRLHEHRTLEFDSTVNYPLDRREV
ATSDTDRAQRTPWNTYMAQGLPATAICSPGVDALRAAEHPVPGDWLYFVTIDSQGTTL
FTRDYQQHLANIELAKHNGVLDSAR"
gene complement(2873258..2873770)
/locus_tag="Rv2554c"
CDS complement(2873258..2873770)
/codon_start=1
/transl_table=11
/locus_tag="Rv2554c"
/product="Conserved protein"
/note="Rv2554c, (MTCY159.02), len: 170 aa. Conserved
protein, equivalent to Q9CCS9|ML0513 hypothetical protein
from Mycobacterium leprae (184 aa), FASTA scores: opt:
701,E(): 2e-34, (72.05% identity in 161 aa overlap). Also
highly similar to Q9KXQ0|SC9C5.24c hypothetical 17.7 KDA
protein from Streptomyces coelicolor (167 aa), FASTA
scores: opt: 461, E(): 2.3e-20, (54.65% identity in 150 aa
overlap); and similar to other hypothetical proteins e.g.
Q9KDE4 from Bacillus halodurans (140 aa), FASTA scores:
opt: 291, E(): 1.9e-10, (38.7% identity in 137 aa
overlap); P74662|SLL1547 from Synechocystis sp. strain PCC
6803 (152 aa), FASTA scores: opt: 290, (36.55% identity in
145 aa overlap); Q52673|YQGF_RHOCA from Rhodobacter
capsulatus (Rhodopseudomonas capsulata) (159 aa), FASTA
scores: opt: 246, E(): 8.4e-08, (34.8% identity in 135 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2554c"
/db_xref="EnsemblGenomes-Tr:CCP45350"
/db_xref="GOA:P9WGV7"
/db_xref="InterPro:IPR005227"
/db_xref="InterPro:IPR006641"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR037027"
/db_xref="UniProtKB/Swiss-Prot:P9WGV7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45350.1"
/translation="MVPAQHRPPDRPGDPAHDPGRGRRLGIDVGAARIGVACSDPDAI
LATPVETVRRDRSGKHLRRLAALAAELEAVEVIVGLPRTLADRIGRSAQDAIELAEAL
ARRVSPTPVRLADERLTTVSAQRSLRQAGVRASEQRAVIDQAAAVAILQSWLDERLAA
MAGTQEGSDA"
gene complement(2873771..2876485)
/gene="alaS"
/locus_tag="Rv2555c"
CDS complement(2873771..2876485)
/codon_start=1
/transl_table=11
/gene="alaS"
/locus_tag="Rv2555c"
/product="Probable alanyl-tRNA synthetase AlaS
(alanine--tRNA ligase) (alanine translase) (ALARS)"
/note="Rv2555c, (MTCY318.01c-MTCY159.01), len: 904 aa.
Probable alaS, alanyl-tRNA synthetase, equivalent to
Q9CCT0|alas|ML0512 alanyl-tRNA synthetase from
Mycobacterium leprae (908 aa), FASTA scores: opt:
5013,E(): 0, (84.65% identity in 907 aa overlap). Also
highly similar to many e.g. Q9KXP9|alas from Streptomyces
coelicolor (890 aa), FASTA scores: opt: 2159, E():
3.8e-118, (53.45% identity in 907 aa overlap); Q9FFC7
Arabidopsis thaliana (Mouse-ear cress) (954 aa), FASTA
scores: opt: 1963, E(): 1.1e-106, (41.1% identity in 925
aa overlap); Q9RS27|DR2300 from Deinococcus radiodurans
(890 aa), FASTA scores: opt: 1352, E(): 4.1e-71, (38.05%
identity in 915 aa overlap); etc. Belongs to class-II
aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2555c"
/db_xref="EnsemblGenomes-Tr:CCP45351"
/db_xref="GOA:P9WFW7"
/db_xref="InterPro:IPR002318"
/db_xref="InterPro:IPR003156"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR012947"
/db_xref="InterPro:IPR018162"
/db_xref="InterPro:IPR018163"
/db_xref="InterPro:IPR018164"
/db_xref="InterPro:IPR018165"
/db_xref="InterPro:IPR023033"
/db_xref="UniProtKB/Swiss-Prot:P9WFW7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45351.1"
/translation="MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQF
VPFFLGQRTPPYPTATSIQKCIRTPDIDEVGITTRHNTFFQMAGNFSFGDYFKRGAIE
LAWALLTNSLAAGGYGLDPERIWTTVYFDDDEAVRLWQEVAGLPAERIQRRGMADNYW
SMGIPGPCGPSSEIYYDRGPEFGPAGGPIVSEDRYLEVWNLVFMQNERGEGTTKEDYQ
ILGPLPRKNIDTGMGVERIALVLQDVHNVYETDLLRPVIDTVARVAARAYDVGNHEDD
VRYRIIADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDAAIVGDLMA
TVRNAMGPSYPELVADFERISRIAVAEETAFNRTLASGSRLFEEVASSTKKSGATVLS
GSDAFTLHDTYGFPIELTLEMAAETGLQVDEIGFRELMAEQRRRAKADAAARKHAHAD
LSAYRELVDAGATEFTGFDELRSQARILGIFVDGKRVPVVAHGVAGGAGEGQRVELVL
DRTPLYAESGGQIADEGTISGTGSSEAARAAVTDVQKIAKTLWVHRVNVESGEFVEGD
TVIAAVDPGWRRGATQGHSGTHMVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGPL
TDDQRTQVEEVTNEAVQADFEVRTFTEQLDKAKAMGAIALFGESYPDEVRVVEMGGPF
SLELCGGTHVSNTAQIGPVTILGESSIGSGVRRVEAYVGLDSFRHLAKERALMAGLAS
SLKVPSEEVPARVANLVERLRAAEKELERVRMASARAAATNAAAGAQRIGNVRLVAQR
MSGGMTAADLRSLIGDIRGKLGSEPAVVALIAEGESQTVPYAVAANPAAQDLGIRAND
LVKQLAVAVEGRGGGKADLAQGSGKNPTGIDAALDAVRSEIAVIARVG"
gene complement(2876576..2876965)
/locus_tag="Rv2556c"
CDS complement(2876576..2876965)
/codon_start=1
/transl_table=11
/locus_tag="Rv2556c"
/product="Conserved hypothetical protein"
/note="Rv2556c, (MTCY09C4.12), len: 129 aa. Conserved
hypothetical protein, highly similar to others e.g.
Q9EWY5|2SCG38.34 conserved hypothetical protein from
Streptomyces coelicolor (140 aa), FASTA scores: opt:
488,E(): 8.2e-26, (58.8% identity in 131 aa overlap);
Q9L9G4|NOVD NOVD protein from Streptomyces sphaeroides
(143 aa), FASTA scores: opt: 474, E(): 7.2e-25, (60.85%
identity in 120 aa overlap); Q9X2I5|TM1872 from Thermotoga
maritima (132 aa), FASTA scores: opt: 270, E(): 2.7e-11,
(39.55% identity in 129 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2556c"
/db_xref="EnsemblGenomes-Tr:CCP45352"
/db_xref="GOA:P9WFP9"
/db_xref="InterPro:IPR001602"
/db_xref="InterPro:IPR035917"
/db_xref="UniProtKB/Swiss-Prot:P9WFP9"
/protein_id="CCP45352.1"
/translation="MLDVDTARRRIVDLTDAVRAFCTAHDDGLCNVFVPHATAGVAII
ETGAGSDEDLVDTLVRLLPRDDRYRHAHGSYGHGADHLLPAFVAPSVTVPVSGGQPLL
GTWQSIVLVDLNQDNPRRSVRLSFVEG"
gene 2877072..2877746
/locus_tag="Rv2557"
CDS 2877072..2877746
/codon_start=1
/transl_table=11
/locus_tag="Rv2557"
/product="Conserved protein"
/note="Rv2557, (MTCY9C4.11c), len: 224 aa. Conserved
protein, highly similar to upstream ORF
Q50740|MTCY9C4.10c|Rv2558|MT2635 conserved hypothetical
protein from Mycobacterium tuberculosis (236 aa), FASTA
scores: opt: 1007, E(): 6.9e-60, (69.2% identity in 224 aa
overlap); and Mb2587 in Mycobacterium bovis (224 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2557"
/db_xref="EnsemblGenomes-Tr:CCP45353"
/db_xref="GOA:P9WLA5"
/db_xref="InterPro:IPR007138"
/db_xref="InterPro:IPR011008"
/db_xref="UniProtKB/Swiss-Prot:P9WLA5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45353.1"
/translation="MTGGATGALPRTMKEGWIVYARSTTIQAQSECIDTGIAHVRDVV
MPALQGMDGCIGVSLLVDRQSGRCIATSAWETAEAMHASREQVTPIRDRCAEMFGGTP
AVEEWEIAAMHRDHRSAEGACVRATWVKVPADQVDQGIEYYKSSVLPQIEGLDGFCSA
SLLVDRTSGRAVSSATFDSFDAMERNRDQSNALKATSLREAGGEELDECEFELALAHL
RVPELV"
gene 2877831..2878541
/locus_tag="Rv2558"
CDS 2877831..2878541
/codon_start=1
/transl_table=11
/locus_tag="Rv2558"
/product="Conserved protein"
/note="Rv2558, (MTCY9C4.10c), len: 236 aa. Conserved
protein, highly similar to downstream ORF
Q50741|MTCY9C4.11c|Rv2557|MT2645 conserved hypothetical
protein from Mycobacterium tuberculosis (224 aa), FASTA
scores: opt: 1007, E(): 4.7e-59, (69.2% identity in 224 aa
overlap); and Mb2588 in Mycobacterium bovis (236 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2558"
/db_xref="EnsemblGenomes-Tr:CCP45354"
/db_xref="GOA:P9WLA3"
/db_xref="InterPro:IPR011008"
/db_xref="UniProtKB/Swiss-Prot:P9WLA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45354.1"
/translation="MPGSAGWRKVFGGTGGATGALPRHGRGSIVYARSTTIEAQPLSV
DIGIAHVRDVVMPALQEIDGCVGVSLLVDRQSGRCIATSAWETLEAMRASVERVAPIR
DRAALMFAGSARVEEWDIALLHRDHPSHEGACVRATWLKVVPDQLGRSLEFYRTSVLP
ELESLDGFCSASLMVDHPACRRAVSCSTFDSMDAMARNRDRASELRSRRVRELGAEVL
DVAEFELAIAHLRVPELV"
gene complement(2878571..2879929)
/locus_tag="Rv2559c"
CDS complement(2878571..2879929)
/codon_start=1
/transl_table=11
/locus_tag="Rv2559c"
/product="Conserved hypothetical alanine leucine valine
rich protein"
/note="Rv2559c, (MTCY9C4.09), len: 452 aa. Conserved
hypothetical ala-, leu-, val-rich protein, equivalent to
Q9CCT1|ML0510 hypothetical protein from Mycobacterium
leprae (473 aa), FASTA scores: opt: 2411, E():
3.9e-121,(83.4% identity in 452 aa overlap); O69490|O69490
hypothetical 47.1 KDA protein from Mycobacterium leprae
(447 aa), FASTA scores: opt: 2406, E(): 6.9e-121, (83.95%
identity in 448 aa overlap). Also highly similar to
Q9KXP4|SC9C5.30c conserved ATP/GTP binding protein from
Streptomyces coelicolor (451 aa), FASTA scores: opt:
1742,E(): 1.5e-85, (64.4% identity in 430 aa overlap);
Q9RT67|DR1898 conserved hypothetical protein from
Deinococcus radiodurans (434 aa), FASTA scores: opt:
1147,E(): 6.6e-54, (46.0% identity in 415 aa overlap);
P45262|YCAJ_HAEIN|HI1590 hypothetical protein from
Haemophilus influenzae (446 aa), FASTA scores: opt:
1140,E(): 1.6e-53, (42.5% identity in 428 aa overlap);
etc. Also similar to
Q50629|MTCY227.09|RUVB|Rv2592c|MT2669|MTCY227.09 holliday
junction DNA helicase from Mycobacterium tuberculosis (344
aa), (30.1% identity in 296 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2559c"
/db_xref="EnsemblGenomes-Tr:CCP45355"
/db_xref="GOA:P9WQN1"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR008921"
/db_xref="InterPro:IPR021886"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR032423"
/db_xref="UniProtKB/Swiss-Prot:P9WQN1"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45355.1"
/translation="MPEAVSDGLFDVPGVPMTSGHDLGASAGAPLAVRMRPASLDEVV
GQDHLLAPGSPLRRLVEGSGVASVILYGPPGSGKTTLAALISQATGRRFEALSALSAG
VKEVRAVIENSRKALLHGEQTVLFIDEVHRFSKTQQDALLSAVEHRVVLLVAATTENP
SFSVVAPLLSRSLILQLRPLTAEDTRAVVQRAIDDPRGLGRAVAVAPEAVDLLVQLAA
GDARRALTALEVAAEAAQAAGELVSVQTIERSVDKAAVRYDRDGDQHYDVVSAFIKSV
RGSDVDAALHYLARMLVAGEDPRFIARRLMILASEDIGMAGPSALQVAVAAAQTVALI
GMPEAQLTLAHATIHLATAPKSNAVTTALAAAMNDIKAGKAGLVPAHLRDGHYSGAAA
LGNAQGYKYSHDDPDGVVAQQYPPDELVDVDYYRPTGRGGEREIAGRLDRLRAIIRKK
RG"
gene 2880075..2881052
/locus_tag="Rv2560"
CDS 2880075..2881052
/codon_start=1
/transl_table=11
/locus_tag="Rv2560"
/product="Probable proline and glycine rich transmembrane
protein"
/note="Rv2560, (MTCY9C4.08c), len: 325 aa. Probable
transmembrane protein, pro-, gly-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv2560"
/db_xref="EnsemblGenomes-Tr:CCP45356"
/db_xref="GOA:P9WLA1"
/db_xref="UniProtKB/Swiss-Prot:P9WLA1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45356.1"
/translation="MSQPPEHPGNPADPQGGNQGAGSYPPPGYGAPPPPPGYGPPPGT
YLPPGYNAPPPPPGYGPPPGPPPPGYPTHLQSSGFSVGDAISWSWNRFTQNAVTLVVP
VLAYAVALAAVIGATAGLVVALSDRATTAYTNTSGVSSESVDITMTPAAGIVMFLGYI
ALFALVLYMHAGILTGCLDIADGKPVTIATFFRPRNLGLVLVTGLLIVAVTFIGGLLC
VIPGLIFGFVAQFAVAFAVDRSTSPIDSVKASIETVGSNIGGSVLSWLAQLTAVLVGE
LLCFVGMLIGIPVAALIHVYTYRKLSGGQVVEAVRPAPPVGWPPGPQLA"
gene 2881252..2881320
/gene="mpr11"
ncRNA 2881252..2881320
/gene="mpr11"
/product="Fragment of putative small regulatory RNA"
/note="mpr11, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), ends not mapped, 82-100 nt
band detected by Northern blot in M. bovis BCG Pasteur."
/ncRNA_class="other"
gene 2881409..2881702
/locus_tag="Rv2561"
CDS 2881409..2881702
/codon_start=1
/transl_table=11
/locus_tag="Rv2561"
/product="Conserved hypothetical protein"
/note="Rv2561, (MTCY9C4.07c), len: 97 aa. Conserved
hypothetical protein, highly similar in part (and longer
33 aa) to upstream ORF AAK46951|RV2562|MT2638|MTCY9C4.06c
conserved hypothetical protein from Mycobacterium
tuberculosis (212 aa), FASTA scores: opt: 205, E():
2e-06,(76.1% identity in 46 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2561"
/db_xref="EnsemblGenomes-Tr:CCP45357"
/db_xref="InterPro:IPR020503"
/db_xref="UniProtKB/Swiss-Prot:P9WL99"
/protein_id="CCP45357.1"
/translation="MGIQRAVLLIADIGGYTNYMHWNRKHLAHAQWTVAQLLESVIDA
AKGMKLAKLEGDAAFFWAPGGQHQCPGMRPAPADAPEVPHAARADQKRPSLRL"
gene 2881758..2882147
/locus_tag="Rv2562"
CDS 2881758..2882147
/codon_start=1
/transl_table=11
/locus_tag="Rv2562"
/product="Conserved hypothetical protein"
/note="Rv2562, (MTCY9C4.06c), len: 129 aa. Conserved
hypothetical protein, highly similar, but shorter 83 aa,
to downstream ORF AAK46951|RV2561|MT2638|MTCY9C4.07c
conserved hypothetical protein from Mycobacterium
tuberculosis (97 aa), FASTA scores: opt: 866, E():
2.2e-54, (100.0% identity in 129 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2562"
/db_xref="EnsemblGenomes-Tr:CCP45358"
/db_xref="InterPro:IPR020503"
/db_xref="UniProtKB/Swiss-Prot:P9WL99"
/protein_id="CCP45358.1"
/translation="MAEQKVKRNVELAGVDVILVHRMLKNEVPVSEYLFMTDVVAQCL
DESVRKLATPLTHDFEGIGETSTHYIDLATSDMPPAVPDHSFFGLLWADVKFEWHALP
YLLGFKKACAGFRSLGRGATEEPAEMG"
gene 2882185..2882276
/gene="mpr12"
ncRNA 2882185..2882276
/gene="mpr12"
/product="Fragment of putative small regulatory RNA"
/note="mpr12, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), ends not mapped, ~118 nt band
detected by Northern blot in M. bovis BCG Pasteur."
/ncRNA_class="other"
gene 2882290..2883339
/locus_tag="Rv2563"
CDS 2882290..2883339
/codon_start=1
/transl_table=11
/locus_tag="Rv2563"
/product="Probable glutamine-transport transmembrane
protein ABC transporter"
/note="Rv2563, (MTCY9C4.05c), len: 349 aa. Probable
glutamine-transport transmembrane protein ABC transporter
(see citation below), highly similar to
O53617|Rv0072|MTV030.16 putative ABC-transporter
transmembrane subunit from Mycobacterium tuberculosis (349
aa), FASTA scores: opt: 1772, E(): 1.1e-89, (76.2%
identity in 349 aa overlap). Also some similarity with
various hypothetical proteins e.g. Q9RYN1|DRA0279
hypothetical 37.1 KDA protein from Deinococcus radiodurans
(353 aa), FASTA scores: opt: 347, E(): 6.6e-12, (24.35%
identity in 357 aa overlap); BAB58522|SAV2360 conserved
hypothetical protein from Staphylococcus aureus subsp.
aureus Mu50 (351 aa),FASTA scores: opt: 262, E(): 2.9e-07,
(19.4% identity in 356 aa overlap); Q9AK94|SC10A9.10c
putative ABC transport system transmembrane protein from
Streptomyces coelicolor (379 aa), FASTA scores: opt: 172,
E(): 0.025, (26.85% identity in 387 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2563"
/db_xref="EnsemblGenomes-Tr:CCP45359"
/db_xref="GOA:P9WG15"
/db_xref="UniProtKB/Swiss-Prot:P9WG15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45359.1"
/translation="MLFAALRDVQWRKRRLVIAIVSTGLVFAMTLVLTGLVNGFRVEA
ERTVDSMGVDAFVVKAGAAGPFLGSTPFAQIDLPQVARAPGVLAAAPLATAPSTIRQG
TSARNVTAFGAPEHGPGMPRVSDGRAPSTPDEVAVSSTLGRNLGDDLQVGARTLRIVG
IVPESTALAKIPNIFLTTEGLQQLAYNGQPTISSIGIDGMPRQLPDGYQTVNRADAVS
DLMRPLKVAVDAITVVAVLLWIVAALIVGSVVYLSALERLRDFAVFKAIGVPTRSILA
GLALQAVVVALLAAVVGGILSLLLAPLFPMTVVVPLSAFVALPAIATVIGLLASVAGL
RRVVAIDPALAFGGP"
gene 2883342..2884334
/gene="glnQ"
/locus_tag="Rv2564"
CDS 2883342..2884334
/codon_start=1
/transl_table=11
/gene="glnQ"
/locus_tag="Rv2564"
/product="Probable glutamine-transport ATP-binding protein
ABC transporter GlnQ"
/note="Rv2564, (MTCY9C4.04c), len: 330 aa. Probable
glnQ,glutamine-transport ATP-binding protein ABC
transporter (see citation below), highly similar to many
e.g. Q9L0J9|SCD40A.12c putative ABC-transporter
ATP-binding protein from Streptomyces coelicolor (246 aa),
FASTA scores: opt: 598, E(): 2.5e-26, (46.35% identity in
218 aa overlap); O54136|SC2E9.11 from Streptomyces
coelicolor (230 aa), FASTA scores: opt: 592, E(): 5.1e-26,
(46.55% identity in 219 aa overlap); O29244|AF1018 from
Archaeoglobus fulgidus (228 aa), FASTA scores: opt: 580,
E(): 2.4e-25,(42.4% identity in 210 aa overlap);
P75831|YBJZ_ECOLI|B0879 from Escherichia coli strain K12
(648 aa), FASTA scores: opt: 555, E(): 1.3e-23, (39.65%
identity in 232 aa overlap); etc. Also highly similar to
O53618|Rv0073|MTV030.17 ABC-transporter ATP-binding
subunit from Mycobacterium tuberculosis (330 aa), FASTA
scores: opt: 1782, E(): 4.7e-92, (83.65% identity in 330
aa overlap); etc. Shows some similarity to
Q11040|YC81_MYCTU|MTCY50.01|Rv1281c|MT1318 hypothetical
ABC transporter ATP-binding protein from Mycobacterium
tuberculosis (612 aa) (32.9 % identity in 234 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A
(P-loop),PS00211 ABC transporters family signature, and
PS00889 Cyclic nucleotide-binding domain signature 2.
Belongs to the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv2564"
/db_xref="EnsemblGenomes-Tr:CCP45360"
/db_xref="GOA:P9WQI5"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR018488"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQI5"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00889"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45360.1"
/translation="MGGLTISDLVVEYSSGGYAVRPIDGLSLDVAPGSLVILLGPSGC
GKTTLLSCLGGILRPKSGSIKFDDVDITTLEGAALAKYRRDKVGIVFQAFNLVSSLTA
LENVMVPLRAAGVSRAAARKRAEDLLIRVNLGERMKHRPGDMSGGQQQRVAVARAIAL
DPQLILADEPTAHLDFIQVEEVLRLIRSLAQGDRVVVVATHDSRMLPLADRVLELMPA
QVSPNQPPETVHVKAGEVLFEQSTMGDLIYVVSEGEFEIVRELADGGEELVKTAAPGD
YFGEIGVLFHLPRSATVRARSDATAVGYTAQAFRERLGVTRVADLIEHRELASE"
gene 2884611..2886362
/locus_tag="Rv2565"
CDS 2884611..2886362
/codon_start=1
/transl_table=11
/locus_tag="Rv2565"
/product="Conserved protein"
/note="Rv2565, (MTCY9C4.03c), len: 583 aa. Conserved
protein, similar in part to Q9A6C3|CC2171 hypothetical
protein from Caulobacter crescentus (610 aa), FASTA
scores: opt: 765, E(): 2.8e-37, (32.15% identity in 575 aa
overlap). C-terminus also highly similar to various
bacterial proteins e.g. O34731|YLBK_BACSU hypothetical
28.3 KDA protein from Bacillus subtilis (260 aa), FASTA
scores: opt: 386, E(): 2.2e-15, (33.05% identity in 245 aa
overlap); CAC45997|SMC01003 conserved hypothetical protein
from Rhizobium meliloti (Sinorhizobium meliloti) (321
aa),FASTA scores: opt: 352, E(): 2.5e-13, (29.65% identity
in 280 aa overlap); Q9K9Q8|BH2587 hypothetical protein
from Bacillus halodurans (275 aa), FASTA scores: opt: 334,
E(): 2.5e-12, (33.7% identity in 175 aa overlap); etc. And
shows similarity to C-terminal half of some eukaryotic
proteins e.g. Q9R114|NTE neuropathy target esterase
homolog from Mus musculus (Mouse) (1327 aa), FASTA scores:
opt: 411, E(): 2.7e-16, (24.45% identity in 626 aa
overlap); O60859 neuropathy target esterase from Homo
sapiens (Human) (1327 aa), FASTA scores: opt: 410, E():
3.1e-16, (24.1% identity in 627 aa overlap);
Q9U969|SWS|CG2212 swiss cheese protein from Drosophila
melanogaster (Fruit fly) (1425 aa), FASTA scores: opt:
401, E(): 1.1e-15, (27.75% identity in 544 aa overlap);
etc. Also shows strong similarity to C-terminal half of
O05884|Z95121|Rv3239c|MTY20B11.14c hypothetical 110.2 KDA
protein from Mycobacterium tuberculosis (1048 aa), FASTA
scores: opt: 648, E(): 3e-30, (36.55% identity in 572 aa
overlap); and O69695|Rv3728|MTV025.076 putative two-domain
membrane protein from Mycobacterium tuberculosis (1065
aa), FASTA scores: opt: 643, E(): 6e-30, (34.3% identity
in 595 aa overlap). Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2565"
/db_xref="EnsemblGenomes-Tr:CCP45361"
/db_xref="GOA:P9WIY7"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR001423"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR018490"
/db_xref="UniProtKB/Swiss-Prot:P9WIY7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45361.1"
/translation="MTTARRRPKRRGTDARTALRNVPILADIDDEQLERLATTVERRH
VPANQWLFHAGEPADSIYIVDSGRFVAVAPEGHVFAEMASGDSIGDLGVIAGAARSAG
VRALRDGVVWRIAAETFTDMLEATPLLQSAMLRAMARMLRQSRPAKTARRPRVIGVVS
NGDTAAAPMVDAIATSLDSHGRTAVIAPPVETTSAVQEYDELVEAFSETLDRAERSND
WVLVVADRGAGDLWRHYVSAQSDRLVVLVDQRYPPDAVDSLATQRPVHLITCLAEPDP
SWWDRLAPVSHHPANSDGFGALARRIAGRSLGLVMAGGGARGLAHFGVYQELTEAGVV
IDRFGGTSSGAIASAAFALGMDAGDAIAAAREFIAGSDPLGDYTIPISALTRGGRVDR
LVQGFFGNTLIEHLPRGFFSVSADMITGDQIIHRRGSVSGAVRASISIPGLIPPVHNG
EQLLVDGGLLNNLPANVMCADTDGEVICVDLRRTFVPSKGFGLLPPIVTPPGLLRRLL
TGTDNALPPLQETLLRAFDLAASTANLRELPRVAAIIEPDVSKIGVLNFKQIDAALEA
GRMAARAALQAQPDLVR"
gene 2886373..2889795
/locus_tag="Rv2566"
CDS 2886373..2889795
/codon_start=1
/transl_table=11
/locus_tag="Rv2566"
/product="Long conserved protein"
/note="Rv2566, (MTCY9C4.02c), len: 1140 aa. Long conserved
protein, equivalent to O53120|ML2678 or MLCB1913.12
hypothetical protein from Mycobacterium leprae (1000
aa),FASTA scores: opt: 760, E(): 7.1e-38, (50.2% identity
in 1128 aa overlap); and middle part equivalent to Q9ZB40
72.2 KDA protein (fragment) from Mycobacterium leprae (644
aa),FASTA scores: opt: 1017, E(): 1.5e-65, (45.65%
identity in 655 aa overlap). Also highly similar to
Q98HG6|MLL2877 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413,
E(): 3.7e-77,(52.4% identity in 1148 aa overlap); and
N-terminus shows similarity with other proteins e.g.
Q9HUN8|PA4926 hypothetical protein from Pseudomonas
aeruginosa (311 aa),FASTA scores: opt: 278, E(): 3e-09,
(29.95% identity in 284 aa overlap); and upstream ORF
Q50652|YP69_MYCTU|Rv2569c|MT2645|MTCY227.32 conserved
hypothetical protein from Mycobacterium tuberculosis (314
aa), FASTA scores: opt: 252, E(): 1.1e-07, (28.9% identity
in 315 aa overlap). Equivalent to AAK46955 from
Mycobacterium tuberculosis strain CDC1551 (1156 aa) but
shorter 16 aa."
/db_xref="EnsemblGenomes-Gn:Rv2566"
/db_xref="EnsemblGenomes-Tr:CCP45362"
/db_xref="GOA:Q50732"
/db_xref="InterPro:IPR002931"
/db_xref="InterPro:IPR013589"
/db_xref="InterPro:IPR018667"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/TrEMBL:Q50732"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45362.1"
/translation="MPLRPTQVSGTGRTRCAGRSGVISSAAMSIKVALEHRTSYTFDR
LVRVYPHIVRLRPAPHSRTSIEAYSLRIEPADHFINWQQDALGNFLARLVFPNPMRQL
RITVGLIADLKVINPFDFFIEDWAEIWPCAGMAYPKALADDLRPYLRPVDEDGDGSGP
GELTQAWVRNFTVPDGTRTIDFLVALNRAINADVGYCVRMEPGVQTPDFTLRTGVGSC
RDSAWLLVSILRQFGLAARFVSGYLVQLASDIEALDGPSGPAADFTDLHAWAEAYIPG
AGWIGLDPTSGLLAGEGHIPLAATPHPASAAPISGGTDVCDTVLEFSNTVTRVHEDPR
VTLPYTDESWKTICEVGQRVDERLAAADVRLTVGGEPTFVSVDNQVAEEWRTAADGPH
KRERASDLAARLKAVWAPQGLIHRGQGRWYPGEPLPRWQIALYWRTDGRPLWTNDALL
ADPWGAPPADPVDDDAAYRVLAGIADGLGLPISQVRPAYEDPLSRLAAAVRMPAGDPV
ESGDDLGCDTNPDTPTGRAALLARLDEAITSPAAYVLPLHRRDDGQGWASANWRLRRG
RIVLLEGDSPAGLRLPLDSISWRPPRASFDADPVAVRSTLPAELHTDRAVVEDPETAP
TTALVAEVRGGLVHIFLPPTDALEHFIDLVARVEAAATTANCPVVIEGYGPPPDPRLT
STTITPDPGVIEVNIAPTASFAEQRQQLETLYQQARLARLTTEAFDVDGTHGGTGGGN
HITLGGVTPADSPLLRRPDLLVSLLTYWQRHPSLSYLFAGRFVGTTSQAPRVDEGRAE
ALYELEIAFAEILRLSPSSGGGRPQPWVTDRALRHLLTDITGNTHRAEFCIDKLYSPD
SARGRLGLLELRGFEMPPHLHMAMVQSLLVRSLVAWFWDQPLRAPLIRHGANLHGRYL
LPHFLIHDIADVAADLRAHGIAFETSWLDPFTEFRFPRIGTAVFDGIEIELRGAIEPW
HTLGEEATAAGTARYVDSSVERIQVRIIGADRHRYVVTCNGYPMPLLATDNPDIHVGG
VRFKAWQPPSALHPTITVDGPLRFELIDIATATSCGGCTYHVAHPGGRAYDEPPVNAV
EAEARRARRFEATGFTPGKLDLSDIREKQARISTDIGAPGILDLRRVRTVQQ"
gene 2889795..2892449
/locus_tag="Rv2567"
CDS 2889795..2892449
/codon_start=1
/transl_table=11
/locus_tag="Rv2567"
/product="Conserved hypothetical alanine and leucine rich
protein"
/note="Rv2567, (MTCY227.34c, MTCY9C4.01c), len: 884 aa.
Conserved hypothetical ala-, leu-rich protein, equivalent
to O53121|ML2679|MLCB1913.13 hypothetical protein from
Mycobacterium leprae (893 aa), FASTA scores: opt:
4326,E(): 0, (75.2% identity in 883 aa overlap); and
similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B19
37_F1_4 hypothetical 61.8 KDA protein from Mycobacterium
leprae (561 aa), FASTA scores: opt: 758, E(): 1.2e-38,
(32.2% identity in 537 aa overlap). Also similar to others
e.g. Q9HUN7|PA4927 hypothetical protein from Pseudomonas
aeruginosa (830 aa), FASTA scores: opt: 1247, E():
2.2e-68,(38.25% identity in 831 aa overlap);
Q98HG7|MLL2876 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (803 aa), FASTA scores: opt: 937,
E(): 1.9e-49,(32.15% identity in 828 aa overlap);
CAC47419|SMC04057 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) (802 aa),
FASTA scores: opt: 900,E(): 3.4e-47, (30.85% identity in
852 aa overlap); etc. And similar to
P71732|YO11_MYCTU|Rv2411c|MT2484|MTCY253.09 conserved
hypothetical protein from Mycobacterium tuberculosis (551
aa), FASTA scores: opt: 781, E(): 4.6e-40, (33.75%
identity in 495 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2567"
/db_xref="EnsemblGenomes-Tr:CCP45363"
/db_xref="GOA:P9WL97"
/db_xref="InterPro:IPR007296"
/db_xref="InterPro:IPR025841"
/db_xref="UniProtKB/Swiss-Prot:P9WL97"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45363.1"
/translation="MAPSASAATNGYDVDRLLAGYRTARAQETLFDLRDGPGAGYDEF
VDDDGNVRPTWTELADAVAERGKAGLDRLRSVVHSLIDHDGITYTAIDAHRDALTGDH
DLEPGPWRLDPLPLVISAADWEVLEAGLVQRSRLLDAILADLYGPRSMLTEGVLPPEM
LFAHPGYVRAANGIQMPGRHQLFMHACDLSRLPDGTFQVNADWTQAPSGSGYAMADRR
VVAHAVPDLYEELAPRPTTPFAQALRLALIDAAPDVAQDPVVVVLSPGIYSETAFDQA
YLATLLGFPLVESADLVVRDGKLWMRSLGTLKRVDVVLRRVDAHYADPLDLRADSRLG
VVGLVEAQHRGTVTVVNTLGSGILENPGLLRFLPQLSERLLDESPLLHTAPVYWGGIA
SERSHLLANVSSLLIKSTVSGETLVGPTLSSAQLADLAVRIEAMPWQWVGQELPQFSS
APTNHAGVLSSAGVGMRLFTVAQRSGYAPMIGGLGYVLAPGPAAYTLKTVAAKDIWVR
PTERAHAEVITVPVLAPPAKTGAGTWAVSSPRVLSDLFWMGRYGERAENMARLLIVTR
ERYHVFRHQQDTDESECVPVLMAALGKITGYDTATGAGSAYDRADMIAVAPSTLWSLT
VDPDRPGSLVQSVEGLALAAQAVRDQLSNDTWMVLANVERAVEHKSDPPQSLAEADAV
LASAQAETLAGMLTLSGVAGESMVHDVGWTMMDIGKRIERGLWLTALLQATLSTVRHP
AAEQAIIEATLVACESSVIYRRRTVGKFSVAAVTELMLFDAQNPRSLVYQLERLRADL
KDLPGSSGSSRPERMVDEMNTRLRRSHPEELEEVSADGLRAELAELLAGIHASLRDVA
DVLTATQLALPGGMQPLWGPDQRRVMPA"
gene complement(2892446..2893471)
/locus_tag="Rv2568c"
CDS complement(2892446..2893471)
/codon_start=1
/transl_table=11
/locus_tag="Rv2568c"
/product="Conserved hypothetical protein"
/note="Rv2568c, (MTCY227.33), len: 341 aa. Conserved
hypothetical protein, highly similar (but longer 60 aa) to
Q98E75|MLR4376 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (308 aa), FASTA scores: opt: 566,
E(): 4.1e-29, (40.2% identity in 291 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2568c"
/db_xref="EnsemblGenomes-Tr:CCP45364"
/db_xref="InterPro:IPR011201"
/db_xref="InterPro:IPR031321"
/db_xref="UniProtKB/Swiss-Prot:P9WL95"
/protein_id="CCP45364.1"
/translation="MRDFHCPNCGQRLAFENSACLSCGSALGFSLGRMALLVIADDAD
VQLCANLHLAQCNWLVPSDQLGGLCSSCVLTIERPSDTNTAGLAEFARAEGAKRRLIA
ELHELKLPIVGRDQDPDHGLAFRLLSSAHENVTTGHQNGVITLDLAEGDDVHREQLRV
EMDEPYRTLLGHFRHEIGHYYFYRLIASSSDYLSRFNELFGDPDADYSQALDRHYRGG
PPEGWQDSFVSSYATMHASEDWAETFAHYLHIRDALDTAAWCGLAPASATFDRPALGP
SAFNTIIDKWLPLSWSLNMVNRSMGHDDLYPFVLPAAVLEKMRFIHTVVDEVAPDFEP
AHSRRTV"
gene complement(2893464..2894408)
/locus_tag="Rv2569c"
CDS complement(2893464..2894408)
/codon_start=1
/transl_table=11
/locus_tag="Rv2569c"
/product="Conserved hypothetical protein"
/note="Rv2569c, (MTCY227.32), len: 314 aa. Conserved
hypothetical protein, equivalent to Q9CCT2|ML0508
hypothetical protein from Mycobacterium leprae (313
aa),FASTA scores: opt: 1723, E(): 1.9e-95, (84.4% identity
in 301 aa overlap); and some similarity with
Q49757|YP69_MYCLE|ML0607|MLCL536.03c|B1937_F2_39
hypothetical 31.1 KDA protein from Mycobacterium leprae
(279 aa), FASTA scores: opt: 305, E(): 4.5e-11, (33.0%
identity in 300 aa overlap). Also similar to to other
hypothetical proteins e.g. Q9HUN8|PA4926 from Pseudomonas
aeruginosa (311 aa), FASTA scores: opt: 704, E():
8.7e-35,(39.7% identity in 320 aa overlap); Q98HG8|MLL2875
from Rhizobium loti (Mesorhizobium loti) (294 aa), FASTA
scores: opt: 521, E(): 6.5e-24, (35.05% identity in 294 aa
overlap); Q9A7W9|CC1600 from Caulobacter crescentus (325
aa), FASTA scores: opt: 510, E(): 3.2e-23, (34.4% identity
in 2588 aa overlap); etc. Also some similarity with
proteins from Mycobacterium tuberculosis e.g.
P71734|Rv2409c|MTCY253.11 conserved hypothetical protein
(279 aa), FASTA scores: opt: 312, E(): 1.7e-11, (34.45%
identity in 296 aa overlap); and Q50732|Rv2566|MTCY9C4.02
long conserved hypothetical protein (1140 aa), FASTA
scores: opt: 252, E(): 2.2e-07, (28.9% identity in 315 aa
overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2569c"
/db_xref="EnsemblGenomes-Tr:CCP45365"
/db_xref="GOA:P9WL93"
/db_xref="InterPro:IPR002931"
/db_xref="InterPro:IPR013589"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/Swiss-Prot:P9WL93"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45365.1"
/translation="MSADSSLSLPLSGTHRYRVTHRTEYRYSDVVTSSYGRGFLTPRN
SLRQRCVAHRLTIDPAPADRSTSRDGYGNISSYFHVTEPHRTLTITSDSIVDVSPPPP
GLYTSGPALQPWEAARPAGLPGSLATEFTLDLNPPEITDAVREYAAPSFLPKRPLVEV
LRDLASRIYTDFTYRSGSTTISTGVNEVLLAREGVCQDFARLAIACLRANGLAACYVS
GYLATDPPPGKDRMIGIDATHAWASVWTPQQPGRFEWLGLDPTNDQLVDQRYIVVGRG
RDYADVPPLRGIIYTNSENSVIDVSVDVVPFEGDALHA"
gene 2894512..2894901
/locus_tag="Rv2570"
CDS 2894512..2894901
/codon_start=1
/transl_table=11
/locus_tag="Rv2570"
/product="Conserved hypothetical protein"
/note="Rv2570, (MTCY227.31c), len: 129 aa. Conserved
hypothetical protein, similar to Q98GQ7|MLR3218
hypothetical protein from Rhizobium loti (Mesorhizobium
loti) (133 aa), FASTA scores: opt: 174, E():
9.6e-05,(32.25% identity in 124 aa overlap); Q9A390|CC3314
hypothetical protein from Caulobacter crescentus (129
aa),FASTA scores: opt: 155, E(): 0.0017, (33.35% identity
in 108 aa overlap); and Q9A2Y0|CC3426 hypothetical protein
from Caulobacter crescentus (120 aa), FASTA scores: opt:
144, E(): 0.0083, (32.95% identity in 91 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2570"
/db_xref="EnsemblGenomes-Tr:CCP45366"
/db_xref="UniProtKB/Swiss-Prot:P9WL91"
/protein_id="CCP45366.1"
/translation="MATWDDVARIVGGLPLTAEQAPHDWRVGRKLLAWERPLRKSDRE
ALTRAGSEPPSGDIVGVRVSDEGVKFALIADEPGVYFTTPHFDGYPAVLVRLAEIEVR
DLEELITEAWLMQAPKQLVQAFLANSG"
gene complement(2894893..2895960)
/locus_tag="Rv2571c"
CDS complement(2894893..2895960)
/codon_start=1
/transl_table=11
/locus_tag="Rv2571c"
/product="Probable transmembrane alanine and valine and
leucine rich protein"
/note="Rv2571c, (MTCY227.30), len: 355 aa. Probable
transmembrane ala-, val-, leu-rich protein, showing some
similarity with other membrane proteins e.g.
Q99340|YFDA_CORGL hypothetical integral membrane protein
from Corynebacterium glutamicum (Brevibacterium flavum)
(359 aa), FASTA scores: opt: 338, E(): 2.5e-13, (29.4%
identity in 255 aa overlap); Q9RD86|SCF43.02 putative
integral membrane protein from Streptomyces coelicolor
(379 aa), FASTA scores: opt: 208, E(): 2.1e-05, (26.05%
identity in 303 aa overlap); Q9RD81|SCF43.07 putative
integral membrane protein from Streptomyces coelicolor
(419 aa),FASTA scores: opt: 205, E(): 3.5e-05, (25.15%
identity in 362 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2571c"
/db_xref="EnsemblGenomes-Tr:CCP45367"
/db_xref="GOA:P9WL89"
/db_xref="UniProtKB/Swiss-Prot:P9WL89"
/protein_id="CCP45367.1"
/translation="MSASLLVRTACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDV
FNHPQAFFAPISAVVCMSATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGV
VVFIALSVAVLCARGLVAQGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVGGGLA
IVFSILLFPPDPVVMLCSARADVLAAVRDILAELVNTVSDPTSAPPDWPMAAADRLHQ
QLNGLIEVRANAAMVARRAPRRWGVRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGG
DKLPTPVHAVLTDLAAGTGLADADPTAANEHAAAARATASTLQSAACGSNEVVRADIV
QACVTDLQRVIERPGPSGMSA"
gene complement(2896013..2897803)
/gene="aspS"
/locus_tag="Rv2572c"
CDS complement(2896013..2897803)
/codon_start=1
/transl_table=11
/gene="aspS"
/locus_tag="Rv2572c"
/product="Probable aspartyl-tRNA synthetase AspS
(aspartate--tRNA ligase) (ASPRS) (aspartic acid
translase)"
/note="Rv2572c, (MTCY227.29), len: 596 aa. Probable
aspS,aspartyl-tRNA synthetase, equivalent to
P36429|SYD_MYCLE|ML0501|MLCB1259.19 aspartyl-tRNA
synthetase from Mycobacterium leprae (589 aa), FASTA
scores: opt: 3534, E(): 1.8e-215, (87.85% identity in 592
aa overlap). Also highly similar to many e.g.
O67589|SYD_AQUAE|AQ_1677 from Aquifex aeolicus (603
aa),FASTA scores: opt: 1829, E(): 8.2e-108, (47.5%
identity in 598 aa overlap); O32038|SYD_BACSU from
Bacillus subtilis (592 aa), FASTA scores: opt: 1732, E():
1.1e-101, (46.25% identity in 597 aa overlap);
P21889|SYD_ECOLI|TLS|B1866 from Escherichia coli strain
K12 (590 aa), FASTA scores: opt: 1588, E(): 1.3e-92,
(47.35% identity in 581 aa overlap); etc. Contains PS00179
Aminoacyl-transfer RNA synthetases class-II signature 1.
Belongs to class-II aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2572c"
/db_xref="EnsemblGenomes-Tr:CCP45368"
/db_xref="GOA:P9WFW3"
/db_xref="InterPro:IPR002312"
/db_xref="InterPro:IPR004115"
/db_xref="InterPro:IPR004364"
/db_xref="InterPro:IPR004365"
/db_xref="InterPro:IPR004524"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR029351"
/db_xref="PDB:5W25"
/db_xref="UniProtKB/Swiss-Prot:P9WFW3"
/inference="protein motif:PROSITE:PS00179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45368.1"
/translation="MFVLRSHAAGLLREGDAGQQVTLAGWVARRRDHGGVIFIDLRDA
SGIAQVVFRDPQDTEVLAQAHRLRAEFCVSVAGVVEIRPEGNANPEIATGEIEVNATS
LTVLGECAPLPFQLDEPAGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHD
FVEIETPTITRSTPEGARDFLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIAR
CYRDEDFRADRQPEFTQLDMEMSFVDAEDIIAISEEVLTELWALIGYRIPTPIPRIGY
AEAMRRFGTDKPDLRFGLELVECTDFFSDTTFRVFQAPYVGAVVMPGGASQPRRTLDG
WQDWAKQRGHRGLAYVLVAEDGTLGGPVAKNLTEAERTGLADHVGAKPGDCIFFSAGP
VKSSRALLGAARVEIANRLGLIDPDAWAFVWVVDPPLFEPADEATAAGEVAVGSGAWT
AVHHAFTAPKPEWEDRIESDTGSVLADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVM
GLDKAEAEEKFGFLLEAFMFGAPPHGGIAFGWDRTTALLAGMDSIREVIAFPKTGGGV
DPLTDAPAPITAQQRKESGIDAQPKRVQQA"
gene 2898043..2898783
/locus_tag="Rv2573"
CDS 2898043..2898783
/codon_start=1
/transl_table=11
/locus_tag="Rv2573"
/product="Conserved hypothetical protein"
/note="Rv2573, (MTCY227.28c), len: 246 aa. Conserved
hypothetical protein, similar to various proteins e.g.
Q9ABG6|CC0261 hypothetical protein from Caulobacter
crescentus (290 aa), FASTA scores: opt: 516, E():
5.8e-26,(40.1% identity in 237 aa overlap); Q99R37|SA2393
hypothetical protein (similar to 2-dehydropantoate
2-reductase) from Staphylococcus aureus subsp. aureus N315
(286 aa), FASTA scores: opt: 368, E(): 1.8e-16, (31.75%
identity in 230 aa overlap); Q9KPQ9|VC2307
2-dehydropantoate 2-reductase from Vibrio cholerae (296
aa), FASTA scores: opt: 223, E(): 3.9e-07, (27.7% identity
in 224 aa overlap); etc. Equivalent to AAK46962 from
Mycobacterium tuberculosis strain CDC1551 (275 aa) but
shorter 29 aa."
/db_xref="EnsemblGenomes-Gn:Rv2573"
/db_xref="EnsemblGenomes-Tr:CCP45369"
/db_xref="GOA:P9WIL1"
/db_xref="InterPro:IPR003710"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR013332"
/db_xref="InterPro:IPR013752"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:4OL9"
/db_xref="UniProtKB/Swiss-Prot:P9WIL1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45369.1"
/translation="MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERT
VVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAE
QFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRY
VAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIV
RKARAHGLATPISDVLVPLLAAASDGPG"
gene 2898806..2899309
/locus_tag="Rv2574"
CDS 2898806..2899309
/codon_start=1
/transl_table=11
/locus_tag="Rv2574"
/product="Conserved protein"
/note="Rv2574, (MTCY227.27c), len: 167 aa. Conserved
protein, showing similarity with Q9K3N3|SCG20A.07
hypothetical 17.4 KDA protein from Streptomyces coelicolor
(157 aa), FASTA scores: opt: 218, E(): 2.8e-08, (30.65%
identity in 150 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2574"
/db_xref="EnsemblGenomes-Tr:CCP45370"
/db_xref="GOA:P9WL87"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/Swiss-Prot:P9WL87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45370.1"
/translation="MYPCERVGLSFTETAPYLFRNTVDLAITPEQLFEVLADPQAWPR
WATVITKVTWTSPEPFGAGTTRIVEMRGGIVGDEEFISWEPFTRMAFRFNECSTRAVG
AFAEDYRVQAIPGGCRLTWTMAQKLAGPARPALFVFRPLLNLALRRFLRNLRRYTDAR
FAAAQQS"
gene 2899339..2900220
/locus_tag="Rv2575"
CDS 2899339..2900220
/codon_start=1
/transl_table=11
/locus_tag="Rv2575"
/product="Possible conserved membrane glycine rich
protein"
/note="Rv2575, (MTCY227.26c), len: 293 aa. Possible
conserved membrane gly-rich protein, highly similar to
hypothetical proteins e.g. Q9RR98|DR2596 conserved
hypothetical protein from Deinococcus radiodurans (313
aa),FASTA scores: opt: 734, E(): 2.8e-38, (42.95% identity
in 291 aa overlap); Q9HV81|PA4717 from Pseudomonas
aeruginosa (297 aa), FASTA scores: opt: 641, E(): 1.5e-32,
(43.35% identity in 300 aa overlap); Q98IA4|MLL2493 from
Rhizobium loti (Mesorhizobium loti) (306 aa), FASTA
scores: opt: 628,E(): 1e-31, (38.45% identity in 307 aa
overlap); etc. Contains PS00142 Neutral zinc
metallopeptidases,zinc-binding region signature."
/db_xref="EnsemblGenomes-Gn:Rv2575"
/db_xref="EnsemblGenomes-Tr:CCP45371"
/db_xref="GOA:P9WL85"
/db_xref="InterPro:IPR007343"
/db_xref="UniProtKB/Swiss-Prot:P9WL85"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45371.1"
/translation="MTFNEGVQIDTSTTSTSGSGGGRRLAIGGGLGGLLVVVVAMLLG
VDPGGVLSQQPLDTRDHVAPGFDLSQCRTGADANRFVQCRVVATGNSVDAVWKPLLPG
YTRPHMRLFSGQVGTGCGPASSEVGPFYCPVDKTAYFDTDFFQVLVTQFGSSGGPFAE
EYVVAHEYGHHVQNLLGVLGRAQQGAQGAAGSGVRTELQADCYAGVWAYYASTVKQES
TGVPYLEPLSDKDIQDALAAAAAVGDDRIQQQTTGRTNPETWTHGSAAQRQKWFTVGY
QTGDPNICDTFSAADLG"
gene complement(2900226..2900690)
/locus_tag="Rv2576c"
CDS complement(2900226..2900690)
/codon_start=1
/transl_table=11
/locus_tag="Rv2576c"
/product="Possible conserved membrane protein"
/note="Rv2576c, (MTCY227.25), len: 154 aa. Possible
conserved membrane protein, showing similarity with Q9ZFC2
hypothetical 15.7 KDA protein from Mycobacterium sp. FM10
(146 aa), FASTA scores: opt: 235, E(): 4.1e-08, (31.35%
identity in 150 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2576c"
/db_xref="EnsemblGenomes-Tr:CCP45372"
/db_xref="GOA:P9WL83"
/db_xref="InterPro:IPR016793"
/db_xref="UniProtKB/Swiss-Prot:P9WL83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45372.1"
/translation="MPAGVGNASGSVLDMTSVRTVPSAVALVTFAGAALSGVIPAIAR
ADPVGHQVTYTVTTTSDLMANIRYMSADPPSMAAFNADSSKYMITLHTPIAGGQPLVY
TATLANPSQWAIVTASGGLRVNPEFHCEIVVDGQVVVSQDGGSGVQCSTRPW"
gene 2900918..2902507
/locus_tag="Rv2577"
CDS 2900918..2902507
/codon_start=1
/transl_table=11
/locus_tag="Rv2577"
/product="Conserved protein"
/note="Rv2577, (MTCY227.24c), len: 529 aa. Conserved
protein, showing similarity with various proteins from
eukaryotes, in particular phosphatases, e.g. Q9SE01|pap
purple acid phosphatase precursor from Glycine max
(Soybean) (464 aa), FASTA scores: opt: 190, E():
0.00026,(27.3% identity in 388 aa overlap);
Q9SVP2|F18A5.90|AT4G13700 hypothetical 53.4 KDA protein
from Arabidopsis thaliana (Mouse-ear cress) (474 aa),
FASTA scores: opt: 280, E(): 6.6e-10, (27.2% identity in
331 aa overlap); Q9FK32 similarity to unknown protein from
Arabidopsis thaliana (Mouse-ear cress) (529 aa), FASTA
scores: opt: 249, E(): 6.2e-08, (25.3% identity in 435 aa
overlap); Q12546|APHA acid phosphatase precursor from
Aspergillus ficuum (614 aa), FASTA scores: opt: 207, E():
2.9e-05, (22.95% identity in 458 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2577"
/db_xref="EnsemblGenomes-Tr:CCP45373"
/db_xref="GOA:P9WL81"
/db_xref="InterPro:IPR004843"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR008963"
/db_xref="InterPro:IPR015914"
/db_xref="InterPro:IPR029052"
/db_xref="InterPro:IPR039331"
/db_xref="UniProtKB/Swiss-Prot:P9WL81"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45373.1"
/translation="MGADLKQPQDADSPPKGVSRRRFLTTGAAAVVGTGVGAGGTALL
SSHPRGPAVWYQRGRSGAPPVGGLHLQFGRNASTEMVVSWHTTDTVGNPRVMLGTPTS
GFGSVVVAETRSYRDAKSNTEVRVNHAHLTNLTPDTDYVYAAVHDGTTPELGTARTAP
SGRKPLRFTSFGDQSTPALGRLADGRYVSDNIGSPFAGDITIAIERIAPLFNLINGDL
CYANLAQDRIRTWSDWFDNNTRSARYRPWMPAAGNHENEVGNGPIGYDAYQTYFAVPD
SGSSPQLRGLWYSFTAGSVRVISLHNDDVCYQDGGNSYVRGYSGGEQRRWLQAELANA
RRDSEIDWVVVCMHQTAISTADDNNGADLGIRQEWLPLFDQYQVDLVVCGHEHHYERS
HPLRGALGTDTRTPIPVDTRSDLIDSTRGTVHLVIGGGGTSKPTNALLFPQPRCQVIT
GVGDFDPAIRRKPSIFVLEDAPWSAFRDRDNPYGFVAFDVDPGQPGGTTSIKATYYAV
TGPFGGLTVIDQFTLTKPRGG"
gene complement(2902509..2903531)
/locus_tag="Rv2578c"
CDS complement(2902509..2903531)
/codon_start=1
/transl_table=11
/locus_tag="Rv2578c"
/product="Conserved hypothetical protein"
/note="Rv2578c, (MTCY227.23), len: 340 aa. Conserved
hypothetical protein, highly similar to hypothetical
proteins (conserved or not) e.g. Q9ZBJ3|SC9C7.17c from
Streptomyces coelicolor (348 aa), FASTA scores: opt:
998,E(): 1.6e-55, (47.6% identity in 355 aa overlap);
Q9I763|PA0069 from Pseudomonas aeruginosa (352 aa), FASTA
scores: opt: 560, E(): 6e-28, (36.6% identity in 284 aa
overlap); Q986C9|MLL7417 from Rhizobium loti
(Mesorhizobium loti) (356 aa), FASTA scores: opt: 550,
E(): 2.6e-27,(39.15% identity in 240 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2578c"
/db_xref="EnsemblGenomes-Tr:CCP45374"
/db_xref="GOA:P9WL79"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR040086"
/db_xref="UniProtKB/Swiss-Prot:P9WL79"
/protein_id="CCP45374.1"
/translation="MRWARQAVAVNGMPVDDGALPGLQRIGLVRSVRAPQFDGITFHE
VLCKSALNKVPNAAALPFRYTVNGYRGCSHACRYCFARPTHEYLDFNPGTDFDTQVVV
KTNVAAVLRHELRRPSWRRETVALGTNTDPYQRAEGRYALMPGIIGALAASGTPLSIL
TKGTLLRRDLPLIAEAAQQVPVSVAVSLAVGDPELHRDVESGTPTPQARLALITAIRA
AGLDCHVMVAPVLPQLTDSGEHLDQLLGQIAAAGATGVTVFGLHLRGSTRGWFMCWLA
RAHPELVSRYRELYRRGPYLPPSYREMLRERVAPLIAKYRLAGDHRPAPPETEAALVP
VQATLF"
gene 2903639..2904541
/gene="dhaA"
/gene_synonym="linB"
/locus_tag="Rv2579"
CDS 2903639..2904541
/codon_start=1
/transl_table=11
/gene="dhaA"
/gene_synonym="linB"
/locus_tag="Rv2579"
/product="Possible haloalkane dehalogenase DhaA
(1-chlorohexane halidohydrolase)"
/note="Rv2579, (MTCY227.22c), len: 300 aa. Possible
dhaA,haloalkane dehalogenase, strictly equivalent to
Q9XB14|ISO-RV2579 haloalkane dehalogenase (1-chlorohexane
halidohydrolase) from Mycobacterium bovis (300 aa), FASTA
scores: opt: 2075, E(): 7.1e-125, (99.35% identity in 300
aa overlap); note that only two residues, 120 and 293 are
different. Also highly similar to others e.g. Q9ZER0|DHAAF
haloalkane dehalogenase from Mycobacterium sp strain GP1
(307 aa), FASTA scores: opt: 842, E(): 2.3e-46, (44.95%
identity in 298 aa overlap); Q53042|DHAA haloalkane
dehalogenase from Rhodococcus rhodochrous, and Pseudomonas
pavonaceae (293 aa), FASTA scores: opt: 837, E():
4.5e-46,(44.6% identity in 298 aa overlap); etc. Note that
this protein may also be a
1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase, because
also highly similar to P51698|LINB_PSEPA
1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase from
Pseudomonas paucimobilis (Sphingomonas paucimobilis) (see
Nagata et al., 1993) (296 aa), FASTA scores: opt:
1494,E(): 6.8e-88, (69.5% identity in 295 aa overlap).
Also shows some similarity with proteins from
Mycobacterium tuberculosis e.g.
Q50670|YM96_MYCTU|Rv2296|MT2353|MTCY339.14c putative
haloalkane dehalogenase (300 aa), FASTA scores: opt:
302,E(): 5.3e-12, (30.85% identity in 295 aa overlap); and
Q50600|YJ33_MYCTU|Rv1833c|MT1881|MTCY1A11.10 hypothetical
32.2 KDA protein (286 aa), FASTA scores: opt: 286, E():
5.3e-11, (29.85% identity in 288 aa overlap). May belong
to alpha/beta hydrolase fold family. Note that previously
known as linB."
/db_xref="EnsemblGenomes-Gn:Rv2579"
/db_xref="EnsemblGenomes-Tr:CCP45375"
/db_xref="GOA:P9WMR9"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR023594"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:2O2H"
/db_xref="PDB:2O2I"
/db_xref="PDB:2QVB"
/db_xref="UniProtKB/Swiss-Prot:P9WMR9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45375.1"
/translation="MTAFGVEPYGQPKYLEIAGKRMAYIDEGKGDAIVFQHGNPTSSY
LWRNIMPHLEGLGRLVACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDALDLGDH
VVLVLHDWGSALGFDWANQHRDRVQGIAFMEAIVTPMTWADWPPAVRGVFQGFRSPQG
EPMALEHNIFVERVLPGAILRQLSDEEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEP
AEVVALVNEYRSWLEETDMPKLFINAEPGAIITGRIRDYVRSWPNQTEITVPGVHFVQ
EDSPEEIGAAIAQFVRRLRSAAGV"
gene complement(2904821..2906092)
/gene="hisS"
/locus_tag="Rv2580c"
CDS complement(2904821..2906092)
/codon_start=1
/transl_table=11
/gene="hisS"
/locus_tag="Rv2580c"
/product="Probable histidyl-tRNA synthetase HisS
(histidine--tRNA ligase) (HISRS) (histidine--translase)"
/note="Rv2580c, (MT2657, MTCY227.21), len: 423 aa.
Probable hisS, histidyl-tRNA synthetase, equivalent to
P46696|SYH_MYCLE|hiss|ML0494|MLCB1259.12|B1177_C3_248
histidyl-tRNA synthetase from Mycobacterium leprae (427
aa), FASTA scores: opt: 2380, E(): 2.1e-131, (85.85%
identity in 417 aa overlap). Also highly similar to many
e.g. Q9KXP2|hiss from Streptomyces coelicolor (425
aa),FASTA scores: opt: 1542, E(): 1.4e-82, (56.0% identity
in 418 aa overlap); O32422|SYH_STAAU|hiss from
Staphylococcus aureus (420 aa), FASTA scores: opt: 1135,
E(): 7.4e-59,(44.9% identity in 412 aa overlap);
P04804|SYH_ECOLI|hiss|B2514 from Escherichia coli strain
K12 (423 aa), FASTA scores: opt: 1099, E(): 9.4e-57,
(43.9% identity in 417 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to class-II
aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2580c"
/db_xref="EnsemblGenomes-Tr:CCP45376"
/db_xref="GOA:P9WFV5"
/db_xref="InterPro:IPR004154"
/db_xref="InterPro:IPR004516"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR015807"
/db_xref="InterPro:IPR033656"
/db_xref="InterPro:IPR036621"
/db_xref="InterPro:IPR041715"
/db_xref="UniProtKB/Swiss-Prot:P9WFV5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45376.1"
/translation="MTEFSSFSAPKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIE
LPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRG
ALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGL
DGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTRRRAGINPLRVLDDKRPELRAM
TASAPVLLDHLSDVAKQHFDTVLAHLDALGVPYVINPRMVRGLDYYTKTAFEFVHDGL
GAQSGIGGGGRYDGLMHQLGGQDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGV
PLGEAAKLRLAVLAGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEA
GTVAVKDLTTGEQVSVSMDSVVAEVISRLAG"
gene complement(2906089..2906763)
/locus_tag="Rv2581c"
CDS complement(2906089..2906763)
/codon_start=1
/transl_table=11
/locus_tag="Rv2581c"
/product="Possible glyoxalase II (hydroxyacylglutathione
hydrolase) (GLX II)"
/note="Rv2581c, (MTCY227.20), len: 224 aa. Possible
glyoxalase II, equivalent to
Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247
hypothetical 23.9 KDA protein from Mycobacterium leprae
(218 aa), FASTA scores: opt: 1264, E(): 7.8e-73, (82.0%
identity in 222 aa overlap). Also highly similar to
Q9KXP1|SC9C5.33c possible hydrolase from Streptomyces
coelicolor (235 aa), FASTA scores: opt: 654, E():
2.9e-34,(46.8% identity in 220 aa overlap); and similar to
Q9CI24|YFCI hypothetical protein from Lactococcus lactis
(subsp. lactis) (Streptococcus lactis) (210 aa), FASTA
scores: opt: 360, E(): 9.9e-16, (35.0% identity in 217 aa
overlap); AAK75726|SP1646 metallo-beta-lactamase
superfamily protein from Streptococcus pneumoniae (209
aa),FASTA scores: opt: 320, E(): 3.3e-13, (35.85% identity
in 198 aa overlap); AAK80229|CAC2272 predicted
Zn-dependent hydrolase of metallo-beta-lactamase
superfamily from Clostridium acetobutylicum (199 aa),
FASTA scores: opt: 282, E(): 8e-11, (32.7% identity in 217
aa overlap); etc. Equivalent to AAK46971 from
Mycobacterium tuberculosis strain CDC1551 (246 aa) but
shorter 22 aa. Belongs to the glyoxalase II family.
Cofactor: binds two zinc ions."
/db_xref="EnsemblGenomes-Gn:Rv2581c"
/db_xref="EnsemblGenomes-Tr:CCP45377"
/db_xref="GOA:P9WMW3"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/Swiss-Prot:P9WMW3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45377.1"
/translation="MLITGFPAGLLACNCYVLAERPGTDAVIVDPGQGAMGTLRRILD
KNRLTPAAVLLTHGHIDHIWSAQKVSDTFGCPTYVHPADRFMLTDPIYGLGPRIAQLV
AGAFFREPKQVVELDRDGDKIDLGGISVNIDHTPGHTRGSVVFRVLQATNNDKDIVFT
GDTLFERAIGRTDLAGGSGRDLLRSIVDKLLVLDDSTVVLPGHGNSTTIGAERRFNPF
LEGLSR"
gene 2906814..2907740
/gene="ppiB"
/gene_synonym="ppi"
/locus_tag="Rv2582"
CDS 2906814..2907740
/codon_start=1
/transl_table=11
/gene="ppiB"
/gene_synonym="ppi"
/locus_tag="Rv2582"
/product="Probable peptidyl-prolyl cis-trans isomerase B
PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl
isomerase)"
/note="Rv2582, (MTCY227.19c), len: 308 aa. Probable ppiB
(alternate gene name: ppi), cyclophilin (peptidyl-prolyl
cis-trans isomerase), equivalent to
P46697|PPIB_MYCLE|PPI|ML0492|MLCB1259.10c|B1177_F3_97
probable peptidyl-prolyl cis-trans isomerase B from
Mycobacterium leprae (295 aa), FASTA scores: opt:
1423,E(): 1.3e-66, (72.2% identity in 295 aa overlap).
Also similar to others e.g. Q9KJG8|PPIB peptidyl-prolyl
cis-trans isomerase from Streptomyces lividans (277
aa),FASTA scores: opt: 485, E(): 3.2e-18, (38.35% identity
in 292 aa overlap); Q9KXP0|SC9C5.34 peptidyl-prolyl
cis-trans isomerase from Streptomyces coelicolor (277 aa),
FASTA scores: opt: 483, E(): 4.1e-18, (38.35% identity in
292 aa overlap); Q9RT72|DR1893 peptidyl-prolyl cis-trans
isomerase from Deinococcus radiodurans (350 aa), FASTA
scores: opt: 296, E(): 2.2e-08, (29.0% identity in 276 aa
overlap); etc. Belongs to the cyclophilin-type PPIase
family."
/db_xref="EnsemblGenomes-Gn:Rv2582"
/db_xref="EnsemblGenomes-Tr:CCP45378"
/db_xref="GOA:P9WHW1"
/db_xref="InterPro:IPR002130"
/db_xref="InterPro:IPR029000"
/db_xref="UniProtKB/Swiss-Prot:P9WHW1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45378.1"
/translation="MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKR
RRILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPP
FKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNE
SPCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTD
QYSANDPKLNEPVIYPRGTLAMANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGL
TTLDKIAKAGVAGGGEDGKPATEVTITSVLLD"
gene complement(2907826..2910198)
/gene="relA"
/locus_tag="Rv2583c"
CDS complement(2907826..2910198)
/codon_start=1
/transl_table=11
/gene="relA"
/locus_tag="Rv2583c"
/product="Probable GTP pyrophosphokinase RelA (ATP:GTP
3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP
synthetase) (GTP diphosphokinase)"
/note="Rv2583c, (MTCY227.18), len: 790 aa. Probable
relA,GTP pyrophosphokinase, equivalent to
Q49640|RELA_MYCLE|ML0491|MLCB1259.09|B1177_C1_168 probable
GTP pyrophosphokinase from Mycobacterium leprae (787
aa),FASTA scores: opt: 4834, E(): 0, (93.4% identity in
790 aa overlap). Also highly similar to others e.g.
O87331|RELA_CORGL|RELA|rel from Corynebacterium glutamicum
(Brevibacterium flavum) (760 aa), FASTA scores: opt:
3375,E(): 1.6e-196, (67.0% identity in 758 aa overlap);
O85709|RELA_STRAT from Streptomyces antibioticus (841
aa),FASTA scores: opt: 3209, E(): 1.9e-186, (63.85%
identity in 786 aa overlap); Q9KDH1|RELA|BH1242 from
Bacillus halodurans (728 aa), FASTA scores: opt: 2195,E():
3.8e-125,(45.65% identity in 714 aa overlap); etc. Belongs
to the RELA / spot family."
/db_xref="EnsemblGenomes-Gn:Rv2583c"
/db_xref="EnsemblGenomes-Tr:CCP45379"
/db_xref="GOA:P9WHG9"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR003607"
/db_xref="InterPro:IPR004095"
/db_xref="InterPro:IPR004811"
/db_xref="InterPro:IPR007685"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR012676"
/db_xref="InterPro:IPR033655"
/db_xref="PDB:5XNX"
/db_xref="UniProtKB/Swiss-Prot:P9WHG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45379.1"
/translation="MAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRR
VRARLARRMTAQRSTTNPVLEPLVAVHREIYPKADLSILQRAYEVADQRHASQLRQSG
DPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGV
TKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKAR
ETLEVIAPLAHRLGMASVKWELEDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRA
EIVNTLTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAA
VGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYG
IAAHWRYKEAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQ
EIFVFTPKGDVITLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVE
VFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREVRRGGLP
LQRLVNGESMAAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELA
ERSTPATMPRRPRSTDDVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHR
TDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEALDRHRLLSDVTRALADEKVNI
LSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA"
gene complement(2910229..2910900)
/gene="apt"
/locus_tag="Rv2584c"
CDS complement(2910229..2910900)
/codon_start=1
/transl_table=11
/gene="apt"
/locus_tag="Rv2584c"
/product="Adenine phosphoribosyltransferase Apt (APRT)
(AMP diphosphorylase) (AMP pyrophosphorylase)
(transphosphoribosidase)"
/note="Rv2584c, (MTCY227.17), len: 223 aa. Probable
apt,adenine phosphoribosyltransferase, similar, but longer
in N-terminus, to others e.g. O87330|APT_CORGL from
Corynebacterium glutamicum (Brevibacterium flavum) (185
aa), FASTA scores: opt: 524, E(): 1.3e-24, (50.95%
identity in 159 aa overlap); P52561|APT_STRCO from
Streptomyces coelicolor (182 aa), FASTA scores: opt: 503,
E(): 2.3e-23,(51.85% identity in 164 aa overlap);
P47956|APT_MUSPA|APRT from Mus pahari (Shrew mouse) (180
aa), FASTA scores: opt: 419, E(): 2.5e-18, (44.7% identity
in 170 aa overlap); P07672|P09993|P77121|APT_ECOLI|B0469
from Escherichia coli strain K12 (183 aa), FASTA scores:
opt: 393, E(): 1.9e-18,(42.6% identity in 162 aa overlap);
etc. Contains PS00103 Purine/ pyrimidine phosphoribosyl
transferases signature,and PS00144 Asparaginase /
glutaminase active site signature 1. Belongs to the
purine/pyrimidine phosphoribosyltransferase family.
Nearest initiation codon indicated by homology is TTG at
17426 or GTG at 17465."
/db_xref="EnsemblGenomes-Gn:Rv2584c"
/db_xref="EnsemblGenomes-Tr:CCP45380"
/db_xref="GOA:P9WQ07"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR005764"
/db_xref="InterPro:IPR029057"
/db_xref="UniProtKB/Swiss-Prot:P9WQ07"
/inference="protein motif:PROSITE:PS00144"
/inference="protein motif:PROSITE:PS00103"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45380.1"
/translation="MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGE
SRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPLFADRRGLAAVTEALADRASGAD
LVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYRAYGAATLEILAEGI
EVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVH
SLSRL"
gene complement(2911004..2912677)
/locus_tag="Rv2585c"
CDS complement(2911004..2912677)
/codon_start=1
/transl_table=11
/locus_tag="Rv2585c"
/product="Possible conserved lipoprotein"
/note="Rv2585c, (MT2662, MTCY227.16), len: 557 aa.
Possible conserved lipoprotein precursor, possibly
attached to the membrane by a lipid anchor and
substrate-binding protein involved in transport,
equivalent to Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C
2_197 hypothetical lipoprotein precursor from
Mycobacterium leprae (555 aa), FASTA scores: opt: 2812,
E(): 9.8e-158,(78.95% identity in 546 aa overlap); and
C-terminus highly similar to C-terminus of
Q49638|DCIAE|B1177_C1_166 DCIAE protein from Mycobacterium
leprae (344 aa), FASTA scores: opt: 1177, E(): 7.4e-62,
(78.6% identity in 229 aa overlap). Also similar in part
to various proteins,principally substrate-binding
proteins, e.g. O87329|DCIAE dipeptide-binding protein from
Corynebacterium glutamicum (Brevibacterium flavum) (502
aa), FASTA scores: opt: 614,E(): 1.2e-28, (30.7% identity
in 427 aa overlap); Q9AKR0|OPPA|CAC49261 putative
oligopeptide uptake ABC transporter periplasmic
solute-binding protein precursor from Rhizobium meliloti
(Sinorhizobium meliloti) (532 aa),FASTA scores: opt: 209,
E(): 7.7e-05, (22.85% identity in 460 aa overlap);
P76128|YDDS_ECOLI|B1487|P77769|P76874 putative ABC
transporter periplasmic binding protein from Escherichia
coli strain K12 (516 aa), FASTA scores: opt: 182, E():
0.0029, (20.0% identity in 315 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2585c"
/db_xref="EnsemblGenomes-Tr:CCP45381"
/db_xref="GOA:P9WL77"
/db_xref="InterPro:IPR000914"
/db_xref="InterPro:IPR039424"
/db_xref="UniProtKB/Swiss-Prot:P9WL77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45381.1"
/translation="MAPRRRRHTRIAGLRVVGTATLVAATTLTACSGSAAAQIDYVVD
GALVTYNTNTVIGAASAGAQAFARTLTGFGYHGPDGQVVADRDFGTVSVVEGSPLILD
YQISDDAVYSDGRPVTCDDLVLAWAAQSGRFPGFDAATQAGYVDIANIECTAGQKKAR
VSFIPDRSVVDHSQLFTATSLMPSHVIADQLHIDVTAALLSNNVSAVEQIARLWNSTW
DLKPGRSHDEVRSRFPSSGPYKIESVLDDGAVVLVANDRWWGTKAITKRITVWPQGAD
IQDRVNNRSVDVVDVAAGSSGSLVTPDSYQRTDYPSAGIEQLIFAPQGSLAQSRTRRA
LALCVPRDAIARDAGVPIANSRLSPATDDALTDADGAAEARQFGRVDPAAARDALGGT
PLTVRIGYGRPNARLAATIGTIADACAPAGITVSDVTVDTPGPQALRDGKIDVLLAST
GGATGSGSSGSCAMDAYDLHSGNGNNLSGYANAQIDGIISALAVSADPAERARLLAEA
APVLWDEMPTLPLYRQQRTLLMSTKMYAVSRNPTRWGAGWNMDRWALAR"
gene complement(2912683..2914011)
/gene="secF"
/locus_tag="Rv2586c"
CDS complement(2912683..2914011)
/codon_start=1
/transl_table=11
/gene="secF"
/locus_tag="Rv2586c"
/product="Probable protein-export membrane protein SecF"
/note="Rv2586c, (MT2663, MTCY227.15), len: 442 aa.
Probable secF, protein-export membrane protein (integral
membrane protein) (see citation below), equivalent to
P38386|SECF_MYCLE|SECF|ML0488|MLCB1259.06|B1177_C3_239
protein-export membrane protein from Mycobacterium leprae
(471 aa), FASTA scores: opt: 1910, E(): 2.9e-104, (72.15%
identity in 456 aa overlap). Also similar to others e.g.
Q9AE06|SECF from Corynebacterium glutamicum
(Brevibacterium flavum) (403 aa), FASTA scores: opt: 1198,
E(): 9.8e-63,(47.1% identity in 399 aa overlap);
Q53956|SECF_STRCO|SCL2.05c from Streptomyces coelicolor
(373 aa), FASTA scores: opt: 670, E(): 6.4e-32, (39.25%
identity in 400 aa overlap); Q55611|SECF_SYNY3|SLR0775
from Synechocystis sp. strain PCC 6803 (315 aa), FASTA
scores: opt: 416, E(): 3.8e-17, (33.8% identity in 296 aa
overlap); etc. Belongs to the SECD/SECF family, SECF
family. Part of the prokaryotic protein translocation
apparatus which comprise SECA|Rv3240c, SECD|Rv2587c,
SECE|Rv0638, SECF,SECG|Rv1440 and SECY|Rv0732."
/db_xref="EnsemblGenomes-Gn:Rv2586c"
/db_xref="EnsemblGenomes-Tr:CCP45382"
/db_xref="GOA:P9WGN9"
/db_xref="InterPro:IPR005665"
/db_xref="InterPro:IPR022645"
/db_xref="InterPro:IPR022646"
/db_xref="InterPro:IPR022813"
/db_xref="UniProtKB/Swiss-Prot:P9WGN9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45382.1"
/translation="MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGH
HSFLSRLYTGTGAFEVVGRRRLWFGVSGAIVAVAIASIVFRGFTFGIDFKGGTTVSFP
RGSTQVAQVEDVYYRALGSEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAF
GPKGTDGQPSKQAISDSAVSETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISA
ITAMLFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHT
TRRTFAEQANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGI
IIGTYSSIFFATPLLVTLRERTELVRNHTRRVLKRRNSGSPAGSEDASTDGGEQPAAA
DEQSLVGITQASSQSAPRAAQGSSKPAPGARPVRPVGTRRPTGKRNAGRR"
gene complement(2914015..2915736)
/gene="secD"
/locus_tag="Rv2587c"
CDS complement(2914015..2915736)
/codon_start=1
/transl_table=11
/gene="secD"
/locus_tag="Rv2587c"
/product="Probable protein-export membrane protein SecD"
/note="Rv2587c, (MTCY227.14), len: 573 aa. Probable
secD,protein-export membrane protein (integral membrane
protein) (see citation below), equivalent to
P38387|SECD_MYCLE|ML0487|MLCB1259.05|B1177_C1_164
protein-export membrane protein from Mycobacterium leprae
(571 aa), FASTA scores: opt: 2948, E(): 2.6e-97, (80.6%
identity in 583 aa overlap). Also similar to others e.g.
Q9AE07|SECD from Corynebacterium glutamicum
(Brevibacterium flavum) (637 aa), FASTA scores: opt: 1023,
E(): 1.9e-29,(44.95% identity in 596 aa overlap);
Q53955|SECD_STRCO from Streptomyces coelicolor (570 aa),
FASTA scores: opt: 864,E(): 7.2e-24, (38.0% identity in
584 aa overlap); O33517|SECD_RHOCA from Rhodobacter
capsulatus (Rhodopseudomonas capsulata) (554 aa), FASTA
scores: opt: 551, E(): 7.6e-13, (32.25% identity in 304 aa
overlap); etc. Equivalent to AAK46977 from Mycobacterium
tuberculosis strain CDC1551 (554 aa) but longer 19 aa.
Belongs to the SecD/SecF family, SecD family. Part of the
prokaryotic protein translocation apparatus which comprise
SECA|Rv3240c, SECD, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440
and SECY|Rv0732."
/db_xref="EnsemblGenomes-Gn:Rv2587c"
/db_xref="EnsemblGenomes-Tr:CCP45383"
/db_xref="GOA:P9WGP1"
/db_xref="InterPro:IPR005791"
/db_xref="InterPro:IPR022645"
/db_xref="InterPro:IPR022646"
/db_xref="InterPro:IPR022813"
/db_xref="UniProtKB/Swiss-Prot:P9WGP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45383.1"
/translation="MASSSAPVHPARYLSVFLVMLIGIYLLVFFTGDKHTAPKLGIDL
QGGTRVTLTARTPDGSAPSREALAQAQQIISARVNGLGVSGSEVVVDGDNLVITVPGN
DGSEARNLGQTARLYIRPVLNSMPAQPAAEEPQPAPSAEPQPPGQPAAPPPAQSGAPA
SPQPGAQPRPYPQDPAPSPNPTSPASPPPAPPAEAPATDPRKDLAERIAQEKKLRQST
NQYMQMVALQFQATRCESDDILAGNDDPKLPLVTCSTDHKTAYLLAPSIISGDQIQNA
TSGMDQRGIGYVVDLQFKGPAANIWADYTAAHIGTQTAFTLDSQVVSAPQIQEAIPGG
RTQISGGDPPFTAATARQLANVLKYGSLPLSFEPSEAQTVSATLGLSSLRAGMIAGAI
GLLLVLVYSLLYYRVLGLLTALSLVASGSMVFAILVLLGRYINYTLDLAGIAGLIIGI
GTTADSFVVFFERIKDEIREGRSFRSAVPRGWARARKTIVSGNAVTFLAAAVLYFLAI
GQVKGFAFTLGLTTILDLVVVFLVTWPLVYLASKSSLLAKPAYNGLGAVQQVARERRA
MARTGRG"
gene complement(2915846..2916193)
/gene="yajC"
/locus_tag="Rv2588c"
CDS complement(2915846..2916193)
/codon_start=1
/transl_table=11
/gene="yajC"
/locus_tag="Rv2588c"
/product="Probable conserved membrane protein secretion
factor YajC"
/note="Rv2588c, (MTCY227.13), len: 115 aa. Probable
yajC,secretion factor, a conserved membrane protein (see
Braunstein & Belisle 2000), equivalent to
Q49647|YP88_MYCLE|ML0486|MLCB1259.04|B1177_C3_235
hypothetical 12.8 KDA protein from Mycobacterium leprae
(114 aa), FASTA scores: opt: 499, E(): 2.7e-26, (77.0%
identity in 100 aa overlap). Also similar to other
proteins e.g. Q9AE08 hypothetical 13.5 KDA protein from
Corynebacterium glutamicum (Brevibacterium flavum) (121
aa), FASTA scores: opt: 222, E(): 5e-08, (39.8% identity
in 103 aa overlap); Q9L292|SCL2.07c putative secreted
protein from Streptomyces coelicolor (169 aa), FASTA
scores: opt: 203, E(): 1.2e-06, (32.05% identity in 106 aa
overlap); Q9CDT0|YWAB unknown protein from Lactococcus
lactis (subsp. lactis) (Streptococcus lactis) (110 aa),
FASTA scores: opt: 150, E(): 0.0026, (30.85% identity in
94 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2588c"
/db_xref="EnsemblGenomes-Tr:CCP45384"
/db_xref="GOA:P9WL75"
/db_xref="InterPro:IPR003849"
/db_xref="UniProtKB/Swiss-Prot:P9WL75"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45384.1"
/translation="MESFVLFLPFLLIMGGFMYFASRRQRRAMQATIDLHDSLQPGER
VHTTSGLEATIVAIADDTIDLEIAPGVVTTWMKLAIRDRILPDDDIDEELNEDLDKDV
DDVAGERRVTNDS"
gene 2916360..2917709
/gene="gabT"
/locus_tag="Rv2589"
CDS 2916360..2917709
/codon_start=1
/transl_table=11
/gene="gabT"
/locus_tag="Rv2589"
/product="4-aminobutyrate aminotransferase GabT
(gamma-amino-N-butyrate transaminase) (GABA transaminase)
(glutamate:succinic semialdehyde transaminase) (GABA
aminotransferase) (GABA-at)"
/note="Rv2589, (MTCY227.12c), len: 449 aa. Probable
gabT,4-aminobutyrate aminotransferase, equivalent to
P40829|GABT_MYCLE|ML0485|MLCB1259.03c|B1177_F2_67
4-aminobutyrate aminotransferase (446 aa), FASTA scores:
opt: 2468, E(): 4.5e-141, (83.75% identity in 449 aa
overlap). Also highly similar to others e.g. O86823|GABT
from Streptomyces coelicolor (444 aa), FASTA scores: opt:
1832, E(): 8e-103, (63.9% identity in 443 aa overlap);
AAK79395|CAC1427 from Clostridium acetobutylicum (445
aa),FASTA scores: opt: 1283, E(): 8.4e-70, (45.75%
identity in 433 aa overlap); Q9KE66|BH0991 from Bacillus
halodurans (443 aa), FASTA scores: opt: 1224, E():
2.9e-66, (44.55% identity in 431 aa overlap); etc.
Contains PS00600 Aminotransferases class-III
pyridoxal-phosphate attachment site. Belongs to class-III
of pyridoxal-phosphate-dependent aminotransferases.
Cofactor: pyridoxal phosphate."
/db_xref="EnsemblGenomes-Gn:Rv2589"
/db_xref="EnsemblGenomes-Tr:CCP45385"
/db_xref="GOA:P9WQ79"
/db_xref="InterPro:IPR004632"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WQ79"
/inference="protein motif:PROSITE:PS00600"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45385.1"
/translation="MASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVAR
AGGGIVEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRTQVAEFTHTCFMVTPYEGYV
AVAEQLNRITPGSGPKRSVLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLT
MALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQV
GANNLAALVIEPIQGEGGFIVPAEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFA
CEHEGPDGLEPDLICTAKGIADGLPLSAVTGRAEIMNAPHVGGLGGTFGGNPVACAAA
LATIATIESDGLIERARQIERLVTDRLTTLQAVDDRIGDVRGRGAMIAVELVKSGTTE
PDAGLTERLATAAHAAGVIILTCGMFGNIIRLLPPLTIGDELLSEGLDIVCAILADL"
gene 2917871..2921377
/gene="fadD9"
/locus_tag="Rv2590"
CDS 2917871..2921377
/codon_start=1
/transl_table=11
/gene="fadD9"
/locus_tag="Rv2590"
/product="Probable fatty-acid-CoA ligase FadD9
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv2590, (MTCY227.11c), len: 1168 aa. Probable
fadD9,fatty-acid-CoA synthetase, highly similar to
O69484|FADD9 (alias Q9CCT4|FADD9|ML0484 but longer 14 aa)
putative acyl-CoA synthetase from Mycobacterium leprae
(1174 aa),FASTA scores: opt: 5247, E(): 0, (68.0% identity
in 1178 aa overlap). N-terminal (approximately 700
residues) similar to other long chain fatty acid ligases.
And C-terminus highly similar to C-terminus of Q9XCF2|PSTB
PSTB protein from Mycobacterium avium (2552 aa), FASTA
scores: opt: 2083, E(): 8.4e-116, (40.8% identity in 1150
aa overlap) (and weak similarity on N-terminus).
C-terminal part highly similar to polyketide synthases and
peptides synthases (weak similarity on N-terminus) e.g.
Q10896|Rv0101|MTCY251.20|NRP probable peptide synthetase
from Mycobacterium tuberculosis (2512 aa), FASTA scores:
opt: 1988, E(): 3.7e-110, (40.2% identity in 1181 aa
overlap); etc. Contains PS00455 putative AMP-binding
domain signature, and PS00061 Short-chain alcohol
dehydrogenase family signature. Seems to belong to the
ATP-dependent AMP-binding enzyme family, and to the
short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv2590"
/db_xref="EnsemblGenomes-Tr:CCP45386"
/db_xref="GOA:Q50631"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR010080"
/db_xref="InterPro:IPR013120"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:Q50631"
/inference="protein motif:PROSITE:PS00455"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45386.1"
/translation="MSINDQRLTRRVEDLYASDAQFAAASPNEAITQAIDQPGVALPQ
LIRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLPRFETITYRELWARAGTLATAL
SAEPAIRPGDRVCVLGFNSVDYTTIDIALIRLGAVSVPLQTSAPVTGLRPIVTETEPT
MIATSIDNLGDAVEVLAGHAPARLVVFDYHGKVDTHREAVEAARARLAGSVTIDTLAE
LIERGRALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRKSSGWFEPS
GYPSITLNFMPMSHVGGRQVLYGTLSNGGTAYFVAKSDLSTLFEDLALVRPTELCFVP
RIWDMVFAEFHSEVDRRLVDGADRAALEAQVKAELRENVLGGRFVMALTGSAPISAEM
TAWVESLLADVHLVEGYGSTEAGMVLNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPR
GELLVKTQTMFPGYYQRPDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLS
QGEFIAVSKLEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRHGIENLKPVIS
ESLQEVARAAGLQSYEIPRDFIIETTPFTLENGLLTGIRKLARPQLKKFYGERLERLY
TELADSQSNELRELRQSGPDAPVLPTLCRAAAALLGSTAADVRPDAHFADLGGDSLSA
LSLANLLHEIFGVDVPVGVIVSPASDLRALADHIEAARTGVRRPSFASIHGRSATEVH
ASDLTLDKFIDAATLAAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGK
LICLVRARSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEADLGLDRVT
WQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLALTGKRKPYIYTSTIAV
GEQIPPEAFTEDADIRAISPTRRIDDSYANGYANSKWAGEVLLREAHEQCGLPVTVFR
CDMILADTSYTGQLNLPDMFTRLMLSLAATGIAPGSFYELDAHGNRQRAHYDGLPVEF
VAEAICTLGTHSPDRFVTYHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEW
LQRFETSLRALPDRQRHASLLPLLHNYREPAKPICGSIAPTDQFRAAVQEAKIGPDKD
IPHLTAAIIAKYISNLRLLGLL"
gene 2921551..2923182
/gene="PE_PGRS44"
/locus_tag="Rv2591"
CDS 2921551..2923182
/codon_start=1
/transl_table=11
/gene="PE_PGRS44"
/locus_tag="Rv2591"
/product="PE-PGRS family protein PE_PGRS44"
/note="Rv2591, (MTCY227.10c), len: 543 aa.
PE_PGRS44,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to others e.g.
O53845|Rv0834c|MTV043.26c from Mycobacterium tuberculosis
(882 aa), FASTA scores: opt: 1813, E(): 5.8e-66, (55.3%
identity in 568 aa overlap). Equivalent to AAK46982 from
Mycobacterium tuberculosis strain CDC1551 (505 aa) but
longer 38 aa. Contains PS00583 pfkB family of carbohydrate
kinases signature 1."
/db_xref="EnsemblGenomes-Gn:Rv2591"
/db_xref="EnsemblGenomes-Tr:CCP45387"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIE9"
/inference="protein motif:PROSITE:PS00583"
/protein_id="CCP45387.1"
/translation="MSFVTAAPEMLATAAQNVANIGTSLSAANATAAASTTSVLAAGA
DEVSQAIARLFSDYATHYQSLNAQAAAFHHSFVQTLNAAGGAYSSAEAANASAQALEQ
NLLAVINAPAQALFGRPLIGNGANGTAASPNGGDGGILYGNGGNGFSQTTAGVAGGAG
GSAGLIGNGGNGGAGGAGAAGGAGGAGGWLLGNGGAGGPGGPTDVPAGTGGAGGAGGD
APLIGWGGNGGPGGFAAFGNGGAGGNGGASGSLFGVGGAGGVGGSSEDVGGTGGAGGA
GRGLFLGLGGDGGAGGTSNNNGGDGGAGGTAGGRLFSLGGDGGNGGAGTAIGSNAGDG
GAGGDSSALIGYAQGGSGGLGGFGESTGGDGGLGGAGAVLIGTGVGGFGGLGGGSNGT
GGAGGAGGTGATLIGLGAGGGGGIGGFAVNVGNGVGGLGGQGGQGAALIGLGAGGAGG
AGGATVVGLGGNGGDGGDGGGLFSIGVGGDGGNAGNGAMPANGGNGGNAGVIANGSFA
PSFVGFGGNGGNGVNGGTGGSGGILFGANGANGPS"
gene complement(2923199..2924233)
/gene="ruvB"
/locus_tag="Rv2592c"
CDS complement(2923199..2924233)
/codon_start=1
/transl_table=11
/gene="ruvB"
/locus_tag="Rv2592c"
/product="Probable holliday junction DNA helicase RuvB"
/note="Rv2592c, (MTCY227.09), len: 344 aa. Probable
ruvB,Holliday junction binding protein (see Mizrahi &
Andersen 1998), equivalent to
P40833|RUVB_MYCLE|ML0483|B1177_C3_227 holliday junction
DNA helicase from Mycobacterium leprae (349 aa), FASTA
scores: opt: 2059, E(): 2.1e-106, (94.45% identity in 342
aa overlap). Also highly similar to others e.g.
Q9AE09|RUVB from Corynebacterium glutamicum
(Brevibacterium flavum) (363 aa), FASTA scores: opt:
1651,E(): 6.5e-84, (75.6% identity in 332 aa overlap);
Q9L291|RUVB from Streptomyces coelicolor (357 aa), FASTA
scores: opt: 1530, E(): 3e-77, (68.2% identity in 343 aa
overlap); P08577|RUVB_ECOLI|B1860|Z2912|ECS2570 from
Escherichia coli strains K12 and O157:H7 (336 aa), FASTA
scores: opt: 1284, E(): 1e-63, (55.45% identity in 330 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Belongs to the RuvB family."
/db_xref="EnsemblGenomes-Gn:Rv2592c"
/db_xref="EnsemblGenomes-Tr:CCP45388"
/db_xref="GOA:P9WGW1"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004605"
/db_xref="InterPro:IPR008823"
/db_xref="InterPro:IPR008824"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR041445"
/db_xref="UniProtKB/Swiss-Prot:P9WGW1"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45388.1"
/translation="MTERSDRDVSPALTVGEGDIDVSLRPRSLREFIGQPRVREQLQL
VIEGAKNRGGTPDHILLSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAML
SNLVEHDVLFIDEIHRIARPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVG
ATTRSGALTGPLRDRFGFTAHMDFYEPAELERVLARSAGILGIELGADAGAEIARRSR
GTPRIANRLLRRVRDFAEVRADGVITRDVAKAALEVYDVDELGLDRLDRAVLSALTRS
FGGGPVGVSTLAVAVGEEAATVEEVCEPFLVRAGMVARTPRGRVATALAWTHLGMTPP
VGASQPGLFE"
gene complement(2924230..2924820)
/gene="ruvA"
/locus_tag="Rv2593c"
CDS complement(2924230..2924820)
/codon_start=1
/transl_table=11
/gene="ruvA"
/locus_tag="Rv2593c"
/product="Probable holliday junction DNA helicase RuvA"
/note="Rv2593c, (MTCY227.08), len: 196 aa. Probable
ruvA,Holliday junction binding protein (see citations
below),equivalent to P40832|RUVA_MYCLE|ML0482|B1177_C2_188
holliday junction DNA helicase from Mycobacterium leprae
(203 aa), FASTA scores: opt: 923, E(): 9.9e-50, (76.85%
identity in 203 aa overlap). Also highly similar to others
e.g. Q9L290|RUVA from Streptomyces coelicolor (201 aa)
(201 aa), FASTA scores: opt: 549, E(): 8.2e-27, (47.55%
identity in 204 aa overlap); Q9AE10|RUVA from
Corynebacterium glutamicum (Brevibacterium flavum) (206
aa), FASTA scores: opt: 440, E(): 4e-20, (47.1% identity
in 206 aa overlap); P08576|RUVA_ECOLI|B1861|Z2913|ECS2571
from Escherichia coli strains K12 and O157:H7 (203 aa),
FASTA scores: opt: 312,E(): 2.8e-12, (34.85% identity in
201 aa overlap); etc. Belongs to the RuvA family."
/db_xref="EnsemblGenomes-Gn:Rv2593c"
/db_xref="EnsemblGenomes-Tr:CCP45389"
/db_xref="GOA:P9WGW3"
/db_xref="InterPro:IPR000085"
/db_xref="InterPro:IPR003583"
/db_xref="InterPro:IPR010994"
/db_xref="InterPro:IPR011114"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR013849"
/db_xref="InterPro:IPR036267"
/db_xref="PDB:2H5X"
/db_xref="PDB:2ZTC"
/db_xref="PDB:2ZTD"
/db_xref="PDB:2ZTE"
/db_xref="UniProtKB/Swiss-Prot:P9WGW3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45389.1"
/translation="MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEA
RLITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLA
DGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGF
AAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR"
gene complement(2924817..2925383)
/gene="ruvC"
/locus_tag="Rv2594c"
CDS complement(2924817..2925383)
/codon_start=1
/transl_table=11
/gene="ruvC"
/locus_tag="Rv2594c"
/product="Probable crossover junction
endodeoxyribonuclease RuvC (holliday junction nuclease)
(holliday junction resolvase)"
/note="Rv2594c, (MTCY227.07), len: 188 aa. Probable
ruvC,Holliday junction resolvase (see citations
below),equivalent to P40834|RUVC_MYCLE|ML0481|B1177_C3_226
crossover junction endodeoxyribonuclease from
Mycobacterium leprae (188 aa), FASTA scores: opt: 984,
E(): 2.3e-55,(81.0% identity in 184 aa overlap). Also
highly similar to others e.g. Q9AE11|RUVC from
Corynebacterium glutamicum (Brevibacterium flavum) (221
aa), FASTA scores: opt: 713,E(): 3.6e-38, (56.9% identity
in 188 aa overlap); Q9L289|RUVC_STRCO|SCL2.10c from
Streptomyces coelicolor (188 aa), FASTA scores: opt: 704,
E(): 1.2e-37, (60.65% identity in 178 aa overlap);
P24239|RUVC_ECOLI|B1863 from Escherichia coli strain K12
(172 aa), FASTA scores: opt: 322, E(): 1.6e-13, (38.65%
identity in 163 aa overlap); etc. Belongs to the RUVC
family. Cofactor: magnesium."
/db_xref="EnsemblGenomes-Gn:Rv2594c"
/db_xref="EnsemblGenomes-Tr:CCP45390"
/db_xref="GOA:P9WGV9"
/db_xref="InterPro:IPR002176"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR020563"
/db_xref="InterPro:IPR036397"
/db_xref="UniProtKB/Swiss-Prot:P9WGV9"
/protein_id="CCP45390.1"
/translation="MRVMGVDPGLTRCGLSLIESGRGRQLTALDVDVVRTPSDAALAQ
RLLAISDAVEHWLDTHHPEVVAIERVFSQLNVTTVMGTAQAGGVIALAAAKRGVDVHF
HTPSEVKAAVTGNGSADKAQVTAMVTKILALQAKPTPADAADALALAICHCWRAPTIA
RMAEATSRAEARAAQQRHAYLAKLKAAR"
gene 2925492..2925737
/gene="vapB40"
/locus_tag="Rv2595"
CDS 2925492..2925737
/codon_start=1
/transl_table=11
/gene="vapB40"
/locus_tag="Rv2595"
/product="Possible antitoxin VapB40"
/note="Rv2595, (MTCY227.06c), len: 81 aa. Possible
vapB40,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2596,see Arcus et al. 2005. Similarity with various
bacterial proteins e.g. O28268|AF2011 conserved
hypothetical protein from Archaeoglobus fulgidus (86 aa),
FASTA scores: opt: 120, E(): 0.13, (34.35% identity in 67
aa overlap); CAC46196|SMC01176 conserved hypothetical
protein from Rhizobium meliloti (Sinorhizobium meliloti)
(79 aa), FASTA scores: opt: 119, E(): 0.14, (33.35%
identity in 63 aa overlap); P37554|SP5T_BACSU|SPOVT stage
V sporulation protein T from Bacillus subtilis (178 aa),
FASTA scores: opt: 104, E(): 2.9, (51.45% identity in 35
aa overlap); etc. Also similar to
O07779|Rv0599c|MTCY19H5.23 hypothetical protein from
Mycobacterium tuberculosis (78 aa), FASTA scores: opt:
160, E(): 0.00026, (35.8% identity in 81 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2595"
/db_xref="EnsemblGenomes-Tr:CCP45391"
/db_xref="GOA:P9WFC3"
/db_xref="InterPro:IPR007159"
/db_xref="InterPro:IPR037914"
/db_xref="UniProtKB/Swiss-Prot:P9WFC3"
/protein_id="CCP45391.1"
/translation="MRTTIDVAGRLVIPKRIRERLGLRGNDQVEITERDGRIEIEPAP
TGVELVREGSVLVARPERPLPPLTDEIVRETLDRTRR"
gene 2925734..2926138
/gene="vapC40"
/locus_tag="Rv2596"
CDS 2925734..2926138
/codon_start=1
/transl_table=11
/gene="vapC40"
/locus_tag="Rv2596"
/product="Possible toxin VapC40. Contains PIN domain."
/note="Rv2596, (MTCY227.05c), len: 134 aa. Possible
vapC40,toxin, part of toxin-antitoxin (TA) operon with
Rv2595,contains PIN domain, see Arcus et al. 2005. Similar
to others in Mycobacterium tuberculosis e.g.
O07780|Rv0598c|MTCY19H5.24 hypothetical 14.8 KDA protein
from (137 aa), FASTA scores: opt: 254, E():
8.8e-11,(41.55% identity in 130 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2596"
/db_xref="EnsemblGenomes-Tr:CCP45392"
/db_xref="GOA:P9WF61"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF61"
/protein_id="CCP45392.1"
/translation="MIAPDTSVLVAGFATWHEGHEAAVRALNRGVHLIAHAAVETYSV
LTRLPPPHRIAPVAVHAYLADITSSNYLALDACSYRGLTDHLAEHDVTGGATYDALVG
FTAKAAGAKLLTRDLRAVETYERLRVEVELVT"
gene 2926355..2926975
/locus_tag="Rv2597"
CDS 2926355..2926975
/codon_start=1
/transl_table=11
/locus_tag="Rv2597"
/product="Probable membrane protein"
/note="Rv2597, (MTCY227.04c), len: 206 aa. Probable
membrane protein. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2597"
/db_xref="EnsemblGenomes-Tr:CCP45393"
/db_xref="GOA:P9WL73"
/db_xref="InterPro:IPR025235"
/db_xref="UniProtKB/Swiss-Prot:P9WL73"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45393.1"
/translation="MGNLLVVIAVALFIAAIVVLVVAIRRPKTPATPGGRRDPLAFDA
MPQFGPRQLGPGAIVSHGGIDYVVRGSVTFREGPFVWWEHLLEGGDTPTWLSVQEDDG
RLELAMWVKRTDLGLQPGGQHVIDGVTFQETERGHAGYTTEGTTGLPAGGEMDYVDCA
SAGQGADESMLLSFERWAPDMGWEIATGKSVLAGELTVYPAPPVSA"
gene 2926986..2927480
/locus_tag="Rv2598"
CDS 2926986..2927480
/codon_start=1
/transl_table=11
/locus_tag="Rv2598"
/product="Conserved hypothetical protein"
/note="Rv2598, (MTCY227.03c), len: 164 aa. Conserved
hypothetical protein, showing similarity with hypothetical
proteins from Streptomyces coelicolor e.g.
Q9X8S3|SCH10.34c (185 aa), FASTA scores: opt: 197, E():
3.5e-06, (34.75% identity in 167 aa overlap); and
Q9L088|SCC24.29c (172 aa),FASTA scores: opt: 149, E():
0.0053, (37.65% identity in 146 aa overlap). Equivalent to
AAK46988 from Mycobacterium tuberculosis strain CDC1551
(154 aa) but longer 10 aa."
/db_xref="EnsemblGenomes-Gn:Rv2598"
/db_xref="EnsemblGenomes-Tr:CCP45394"
/db_xref="InterPro:IPR024486"
/db_xref="UniProtKB/Swiss-Prot:P9WL71"
/protein_id="CCP45394.1"
/translation="MPLHQLAIAPVDVSGALLGLVLNAPAPRPLATHRLAHTDGSALQ
LGVLGASHVVTVEGRFCEEVSCVARSRGGDLPESTHAPGYHLQSHTETHDEAAFRRLA
RHLRERCTRATGWLGGVFPGDDAALTALAAEPDGTGWRWRTWHLYPSASGGTVVHTTS
RWRP"
gene 2927477..2927908
/locus_tag="Rv2599"
CDS 2927477..2927908
/codon_start=1
/transl_table=11
/locus_tag="Rv2599"
/product="Probable conserved membrane protein"
/note="Rv2599, (MTCY227.02c), len: 143 aa. Probable
conserved membrane protein, equivalent to Q9K536|2599
hypothetical 15.0 KDA protein (fragment) from
Mycobacterium paratuberculosis (143 aa), FASTA scores:
opt: 691, E(): 1.7e-33, (68.55% identity in 143 aa
overlap). Shows weak similarity with Q9L089|SCC24.28c
putative lipoprotein from Streptomyces coelicolor (131
aa), FASTA scores: opt: 130,E(): 0.52, (26.45% identity in
136 aa overlap). Contains PS00626 Regulator of chromosome
condensation (RCC1) signature 2. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2599"
/db_xref="EnsemblGenomes-Tr:CCP45395"
/db_xref="GOA:P9WL69"
/db_xref="InterPro:IPR025341"
/db_xref="UniProtKB/Swiss-Prot:P9WL69"
/inference="protein motif:PROSITE:PS00626"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45395.1"
/translation="MSRNRLFLVAGSLAVAAAVSLISGITLLNRDVGSYIASHYRQES
RDVNGTRYLCTGSPKQVATTLVKYQTPAARASHTDTEYLRYRNNIVTVGPDGTYPCII
RVENLSAGYNHGAYVFLGPGFTPGSPSGGSGGSPGGPGGSK"
gene 2927990..2928391
/locus_tag="Rv2600"
CDS 2927990..2928391
/codon_start=1
/transl_table=11
/locus_tag="Rv2600"
/product="Probable conserved integral membrane protein"
/note="Rv2600, (MTCY277.01c, MTV001.01), len: 133 aa.
Probable conserved integral membrane protein, equivalent
(but shorter 18 aa) to Q9K537|YQ00_MYCPA hypothetical
protein RV2600 homolog from Mycobacterium paratuberculosis
(151 aa), FASTA scores: opt: 543, E(): 4.2e-28, (62.9%
identity in 132 aa overlap). Also some similarity with
other hypothetical or membrane proteins e.g.
Q9L090|SCC24.27c putative integral membrane protein from
Streptomyces coelicolor (146 aa), FASTA scores: opt:
241,E(): 8.7e-09, (34.8% identity in 135 aa overlap);
O58487|PH0773 hypothetical 15.0 KDA protein from
Pyrococcus horikoshii (138 aa), FASTA scores: opt: 116,
E(): 0.84,(34.35% identity in 96 aa overlap); etc.
Equivalent to AAK46990 from Mycobacterium tuberculosis
strain CDC1551 (152 aa) but shorter 19 aa."
/db_xref="EnsemblGenomes-Gn:Rv2600"
/db_xref="EnsemblGenomes-Tr:CCP45396"
/db_xref="GOA:P9WFG5"
/db_xref="InterPro:IPR007140"
/db_xref="UniProtKB/Swiss-Prot:P9WFG5"
/protein_id="CCP45396.1"
/translation="MVATVLYFLVGAAVLVAGFLMVNLLTPGDLRRLVFIDRRPNAVV
LAATMYVALAIVTIAAIYASSNQLAQGLIGVAVYGIVGVALQGVALVILEIAVPGRFR
EHIDAPALHPAVFATAVMLLAVAGVIAAALS"
gene 2928388..2929959
/gene="speE"
/locus_tag="Rv2601"
CDS 2928388..2929959
/codon_start=1
/transl_table=11
/gene="speE"
/locus_tag="Rv2601"
/product="Probable spermidine synthase SpeE (putrescine
aminopropyltransferase) (aminopropyltransferase) (SPDSY)"
/note="Rv2601, (MTCI270.04c-MTV001.02), len: 523 aa.
Probable speE, spermidine synthase, highly similar to many
e.g. Q9L091|SCC24.26c from Streptomyces coelicolor (531
aa), FASTA scores: opt: 1493, E(): 1.3e-79, (48.45%
identity in 514 aa overlap); Q9X8S2|SCH10.33c from
Streptomyces coelicolor (554 aa), FASTA scores: opt:
1045,E(): 1.7e-53, (40.55% identity in 525 aa overlap);
P09158|SPEE_ECOLI|B0121 from Escherichia coli strain K12
(287 aa), FASTA scores: opt: 368, E(): 2.9e-14, (30.5%
identity in 272 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2601"
/db_xref="EnsemblGenomes-Tr:CCP45397"
/db_xref="GOA:P9WGE5"
/db_xref="InterPro:IPR001045"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR030373"
/db_xref="InterPro:IPR030374"
/db_xref="UniProtKB/Swiss-Prot:P9WGE5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45397.1"
/translation="MTSTRQAGEATEASVRWRAVLLAAVAACAACGLVYELALLTLAA
SLNGGGIVATSLIVAGYIAALGAGALLIKPLLAHAAIAFIAVEAVLGIIGGLSAAALY
AAFAFLDELDGSTLVLAVGTALIGGLVGAEVPLLMTLLQRGRVAGAADAGRTLANLNA
ADYLGALVGGLAWPFLLLPQLGMIRGAAVTGIVNLAAAGVVSIFLLRHVVSGRQLVTA
LCALAAALGLIATLLVHSHDIETTGRQQLYADPIIAYRHSAYQEIVVTRRGDDLRLYL
DGGLQFCTRDEYRYTESLVYPAVSDGARSVLVLGGGDGLAARELLRQPGIEQIVQVEL
DPAVIELARTTLRDVNAGSLDNPRVHVVIDDAMSWLRGAAVPPAGFDAVIVDLRDPDT
PVLGRLYSTEFYALAARALAPGGLMVVQAGSPYSTPTAFWRIISTIRSAGYAVTPYHV
HVPTFGDWGFALARLTDIAPTPAVPSTAPALRFLDQQVLEAATVFSGDIRPRTLDPST
LDNPHIVEDMRHGWD"
gene 2930070..2930357
/gene="vapB41"
/locus_tag="Rv2601A"
CDS 2930070..2930357
/codon_start=1
/transl_table=11
/gene="vapB41"
/locus_tag="Rv2601A"
/product="Possible antitoxin VapB41"
/note="Rv2601A, len: 95 aa. Possible vapB41,
antitoxin,part of toxin-antitoxin (TA) operon with Rv2602,
see Arcus et al. 2005. Similar to others in Mycobacterium
tuberculosis e.g. O53811|Rv0748 conserved hypothetical
protein (88 aa), FASTA scores: opt: 132, E():
0.017,(29.25% identity in 82 aa overlap); O53218|Rv2493
(73 aa),FASTA scores: opt: 107, E(): 0.97, (33.75%
identity in 83 aa overlap); and Q10799|YS71_MYCTU|Rv2871
conserved hypothetical protein from Mycobacterium
tuberculosis (85 aa), FASTA scores: opt: 108, E(): 0.91,
(41.00% identity in 39 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2601A"
/db_xref="EnsemblGenomes-Tr:CCP45398"
/db_xref="GOA:P9WJ21"
/db_xref="InterPro:IPR010985"
/db_xref="InterPro:IPR013321"
/db_xref="UniProtKB/Swiss-Prot:P9WJ21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45398.1"
/translation="MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSG
APIPTPRRVQLPLVHCGGAATREQEMTPERVAAALLDQEAQWWSGHDDAAL"
gene 2930344..2930784
/gene="vapC41"
/locus_tag="Rv2602"
CDS 2930344..2930784
/codon_start=1
/transl_table=11
/gene="vapC41"
/locus_tag="Rv2602"
/product="Possible toxin VapC41. Contains PIN domain."
/note="Rv2602, (MTCI270A.03c), len: 146 aa. Possible
vapC41, toxin, part of toxin-antitoxin (TA) operon with
Rv2601A, contains PIN domain, see Arcus et al. 2005.
Similar to others in Mycobacterium tuberculosis (strains
H37Rv and CDC1551) e.g. O50457|Rv1242|MTV006.14 (143
aa),FASTA scores: opt: 147, E(): 0.0021, (26.25% identity
in 141 aa overlap); P95023|Rv2530c|MTCY159.26 (139 aa),
FASTA scores: opt: 131, E(): 0.027, (33.35% identity in
135 aa overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA
scores: opt: 125, E(): 0.072, (26.45% identity in 140 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2602"
/db_xref="EnsemblGenomes-Tr:CCP45399"
/db_xref="GOA:P9WF59"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF59"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45399.1"
/translation="MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQ
SLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDDRIVLAGAEPDGLEAQWRAFAVR
QSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK"
gene complement(2930805..2931560)
/locus_tag="Rv2603c"
CDS complement(2930805..2931560)
/codon_start=1
/transl_table=11
/locus_tag="Rv2603c"
/product="Highly conserved protein"
/note="Rv2603c, (MTCI270A.02), len: 251 aa. Highly
conserved protein, equivalent to
Q49645|YQ03_MYCLE|ML0475|U1177B|B1177_C2_181 hypothetical
26.6 KDA protein from Mycobacterium leprae (251 aa), FASTA
scores: opt: 1514, E(): 2.2e-84, (92.45% identity in 251
aa overlap). Also highly similar to Q9L288|SCL2.11c
hypothetical 26.8 KDA protein from Streptomyces coelicolor
(250 aa), FASTA scores: opt: 1268, E(): 1.5e-69, (76.7%
identity in 249 aa overlap); Q9AE12|YFCA hypothetical
structural protein from Corynebacterium glutamicum
(Brevibacterium flavum) (251 aa), FASTA scores: opt:
1231,E(): 2.6e-67, (72.9% identity in 251 aa overlap);
O83487|Y474_TREPA|TP0474 hypothetical protein from
Treponema pallidum (245 aa), FASTA scores: opt: 780, E():
4.4e-40, (47.75% identity in 245 aa overlap);
P24237|YEBC_ECOLI|B1864 protein YEBC from Escherichia coli
strain K12 (246 aa), FASTA scores: opt: 776, E():
7.6e-40,(47.8% identity in 249 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2603c"
/db_xref="EnsemblGenomes-Tr:CCP45400"
/db_xref="GOA:P9WGA5"
/db_xref="InterPro:IPR002876"
/db_xref="InterPro:IPR017856"
/db_xref="InterPro:IPR026564"
/db_xref="InterPro:IPR029072"
/db_xref="UniProtKB/Swiss-Prot:P9WGA5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45400.1"
/translation="MSGHSKWATTKHKKAVVDARRGKMFARLIKNIEVAARVGGGDPA
GNPTLYDAIQKAKKSSVPNENIERARKRGAGEEAGGADWQTIMYEGYAPNGVAVLIEC
LTDNRNRAASEVRVAMTRNGGTMADPGSVSYLFSRKGVVTLEKNGLTEDDVLAAVLEA
GAEDVNDLGDSFEVISEPAELVAVRSALQDAGIDYESAEASFQPSVSVPVDLDGARKV
FKLVDALEDSDDVQNVWTNVDVSDEVLAALDDE"
gene complement(2931693..2932289)
/gene="snoP"
/locus_tag="Rv2604c"
CDS complement(2931693..2932289)
/codon_start=1
/transl_table=11
/gene="snoP"
/locus_tag="Rv2604c"
/product="Probable glutamine amidotransferase SnoP"
/note="Rv2604c, (MTCY01A10.29, MTCI270A.01), len: 198 aa.
Probable snoP, glutamine amidotransferase, equivalent (but
shorter 21 aa) to Q49637|HISH|B1177_C1_149 HISH protein
(belongs to the YFL060C/YAAE/HI1648 family) (alias
Q9CCT5|ML0474 hypothetical protein 223 aa) from
Mycobacterium leprae (219 aa), FASTA scores: opt:
1069,E(): 1.7e-60, (83.35% identity in 198 aa overlap).
Also highly similar to hypothetical proteins or
amidotransferases e.g. Q9L287|SCL2.12c hypothetical 21.5
KDA protein from Streptomyces coelicolor (202 aa), FASTA
scores: opt: 702, E(): 2.3e-37, (56.75% identity in 192 aa
overlap); P37528|YAAE_BACSU hypothetical 21.4 KDA protein
from Bacillus subtilis (196 aa), FASTA scores: opt:
608,E(): 1.9e-31, (48.7% identity in 189 aa overlap);
Q9KGN5|BH0023 amidotransferase from Bacillus halodurans
(196 aa), FASTA scores: opt: 583, E(): 7.4e-30, (48.7%
identity in 195 aa overlap); etc. Also some similarity
with several proteins from Mycobacterium tuberculosis e.g.
O06589|HIS5_MYCTU|Rv1602|MT1638|MTCY336.02c
amidotransferase (206 aa), FASTA scores: opt: 154, E():
0.00036, (30.6% identity in 193 aa overlap). Contains a
Pfam match to entry PF01174 SNO glutamine amidotransferase
family. Note possibly co-regulated with snzP (Rv2606c)."
/db_xref="EnsemblGenomes-Gn:Rv2604c"
/db_xref="EnsemblGenomes-Tr:CCP45401"
/db_xref="GOA:P9WII7"
/db_xref="InterPro:IPR002161"
/db_xref="InterPro:IPR021196"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:P9WII7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45401.1"
/translation="MSVPRVGVLALQGDTREHLAALRECGAEPMTVRRRDELDAVDAL
VIPGGESTTMSHLLLDLDLLGPLRARLADGLPAYGSCAGMILLASEILDAGAAGRQAL
PLRAMNMTVRRNAFGSQVDSFEGDIEFAGLDDPVRAVFIRAPWVERVGDGVQVLARAA
GHIVAVRQGAVLATAFHPEMTGDRRIHQLFVDIVTSAA"
gene complement(2932297..2933142)
/gene="tesB2"
/locus_tag="Rv2605c"
CDS complement(2932297..2933142)
/codon_start=1
/transl_table=11
/gene="tesB2"
/locus_tag="Rv2605c"
/product="Probable acyl-CoA thioesterase II TesB2 (TEII)"
/note="Rv2605c, (MTCY01A10.28), len: 281 aa. Probable
tesB2, acyl-CoA thioesterase II, highly similar to others
e.g. Q98EG9|MLL4250 from Rhizobium loti (Mesorhizobium
loti) (286 aa), FASTA scores: opt: 563, E():
3.9e-29,(47.75% identity in 287 aa overlap); CAC47767 from
Rhizobium meliloti (Sinorhizobium meliloti) (294 aa),
FASTA scores: opt: 553, E(): 1.8e-28, (49.3% identity in
280 aa overlap); P23911|TESB_ECOLI|B0452 from Escherichia
coli strain K12 (285 aa), FASTA scores: opt: 487, E():
3.1e-24,(41.9% identity in 277 aa overlap); etc. Also
similar to O06135|TESB1|Rv1618|MTCY01B2.10 acyl-CoA
thioesterase II from Mycobacterium tuberculosis (300 aa),
FASTA scores: opt: 425, E(): 1.1e-21, (34.9% identity in
278 aa overlap). Belongs to the C/M/P thioester hydrolase
family."
/db_xref="EnsemblGenomes-Gn:Rv2605c"
/db_xref="EnsemblGenomes-Tr:CCP45402"
/db_xref="GOA:I6X4S7"
/db_xref="InterPro:IPR003703"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR042171"
/db_xref="UniProtKB/TrEMBL:I6X4S7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45402.1"
/translation="MSIEEILDLEQLEVNIYRGSVFSPESGFLQRTFGGHVAGQSLVS
AVRTVDPRYMVHSLHGYFLRPGDAKERTVFLVERIRDGGSFCTRRVNAVQHGETIFSM
AASFQTEQEGITHQDVMPAAPPPDGLPGLNSIKVFDDAGFRQFDEWDVCIVPRERLRL
LPGKASQQQVWLRHRDPLPDDPVLHICALAYMSDLTLLGSAQVNHLDVRDQLQVASLD
HAMWFMRPFRADEWLLYDQSSPSASGGRALTRGEIFTRSGEMVAAVMQEGLTRHRRGH
RSVGQ"
gene complement(2933171..2934070)
/gene="snzP"
/locus_tag="Rv2606c"
CDS complement(2933171..2934070)
/codon_start=1
/transl_table=11
/gene="snzP"
/locus_tag="Rv2606c"
/product="Possible pyridoxine biosynthesis protein SnzP"
/note="Rv2606c, (MTCY01A10.27), len: 299 aa. Probable
snzP,pyridoxine biosynthesis protein. Highly similar to
O07145|YQ06_MYCLE|ML0450|MLCL581.12c possible pyridoxine
biosynthesis protein from Mycobacterium leprae (307
aa),FASTA scores: opt: 1686, E(): 1.5e-95, (89.7% identity
in 291 aa overlap). Also highly similar to several
pyridoxine biosynthesis proteins and hypothetical proteins
e.g. Q9L286|SCL2.13c hypothetical 32.2 KDA protein from
Streptomyces coelicolor (303 aa), FASTA scores: opt:
1461,E(): 7.6e-82, (76.8% identity in 293 aa overlap);
O14027|YEM4_SCHPO|SPAC29B12.04 putative stress-induced
protein from Schizosaccharomyces pombe (Fission yeast)
(296 aa), FASTA scores: opt: 1318, E(): 3.8e-73, (70.35%
identity in 290 aa overlap); Q9UW83|PYROA protein involved
in pyridoxine biosynthesis from Emericella nidulans
(Aspergillus nidulans) (see citation below) (304 aa),
FASTA scores: opt: 1288, E(): 2.6e-71, (67.9% identity in
302 aa overlap); etc. Contains Pfam match to entry
PF01680,SOR_SNZ family. Contains PS01235 Uncharacterized
protein family UPF0019 signature. Belongs to the SOR_SNZ
family. Note possibly co-regulated with snoP (Rv2604c)."
/db_xref="EnsemblGenomes-Gn:Rv2606c"
/db_xref="EnsemblGenomes-Tr:CCP45403"
/db_xref="GOA:P9WII9"
/db_xref="InterPro:IPR001852"
/db_xref="InterPro:IPR011060"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR033755"
/db_xref="PDB:4JDY"
/db_xref="UniProtKB/Swiss-Prot:P9WII9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45403.1"
/translation="MDPAGNPATGTARVKRGMAEMLKGGVIMDVVTPEQARIAEGAGA
VAVMALERVPADIRAQGGVSRMSDPDMIEGIIAAVTIPVMAKVRIGHFVEAQILQTLG
VDYIDESEVLTPADYAHHIDKWNFTVPFVCGATNLGEALRRISEGAAMIRSKGEAGTG
DVSNATTHMRAIGGEIRRLTSMSEDELFVAAKELQAPYELVAEVARAGKLPVTLFTAG
GIATPADAAMMMQLGAEGVFVGSGIFKSGAPEHRAAAIVKATTFFDDPDVLAKVSRGL
GEAMVGINVDEIAVGHRLAQRGW"
gene 2934198..2934872
/gene="pdxH"
/locus_tag="Rv2607"
CDS 2934198..2934872
/codon_start=1
/transl_table=11
/gene="pdxH"
/locus_tag="Rv2607"
/product="Probable pyridoxamine 5'-phosphate oxidase PdxH
(PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX)
(pyridoxine 5'-phosphate oxidase)"
/note="Rv2607, (MTCY01A10.26c), len: 224 aa. Probable
pdxH,pyridoxinephosphate oxidase, equivalent to
O33065|PDXH_MYCLE|ML2131|MLCB57.46 pyridoxamine
5'-phosphate oxidase from Mycobacterium leprae (219
aa),FASTA scores: opt: 1038, E(): 8.3e-61, (67.1% identity
in 219 aa overlap). Also similar to others e.g.
Q9I4S5|PDXH|PA1049 from Pseudomonas aeruginosa (215
aa),FASTA scores: opt: 608, E(): 1.1e-32, (49.55% identity
in 218 aa overlap); Q9K3V7|SCD10.19c from Streptomyces
coelicolor (234 aa), FASTA scores: opt: 600, E():
3.9e-32,(42.3% identity in 234 aa overlap);
P28225|PDXH_ECOLI|B1638 from Escherichia coli strain K12
(217 aa), FASTA scores: opt: 533, E(): 8.9e-28, (40.3%
identity in 216 aa overlap); etc. Contains a match to Pfam
entry PF01243 Pyridoxamine 5'-phosphate oxidase. Belongs
to the pyridoxamine 5'-phosphate oxidase family. Cofactor:
FMN."
/db_xref="EnsemblGenomes-Gn:Rv2607"
/db_xref="EnsemblGenomes-Tr:CCP45404"
/db_xref="GOA:P9WIJ1"
/db_xref="InterPro:IPR000659"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR019576"
/db_xref="InterPro:IPR019740"
/db_xref="PDB:2A2J"
/db_xref="UniProtKB/Swiss-Prot:P9WIJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45404.1"
/translation="MDDDAQMVAIDKDQLARMRGEYGPEKDGCGDLDFDWLDDGWLTL
LRRWLNDAQRAGVSEPNAMVLATVADGKPVTRSVLCKILDESGVAFFTSYTSAKGEQL
AVTPYASATFPWYQLGRQAHVQGPVSKVSTEEIFTYWSMRPRGAQLGAWASQQSRPVG
SRAQLDNQLAEVTRRFADQDQIPVPPGWGGYRIAPEIVEFWQGRENRMHNRIRVANGR
LERLQP"
gene 2935046..2936788
/gene="PPE42"
/locus_tag="Rv2608"
CDS 2935046..2936788
/codon_start=1
/transl_table=11
/gene="PPE42"
/locus_tag="Rv2608"
/product="PPE family protein PPE42"
/note="Rv2608, (MTCY01A10.25c), len: 580 aa. PPE42, Member
of the Mycobacterium tuberculosis PPE family, highly
similar to many e.g. O06828|Rv1430|MTCY493.24c from
Mycobacterium tuberculosis (528 aa), FASTA scores: opt:
1004, E(): 5.9e-48, (56.05% identity in 307 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2608"
/db_xref="EnsemblGenomes-Tr:CCP45405"
/db_xref="GOA:P9WHZ5"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHZ5"
/protein_id="CCP45405.1"
/translation="MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGS
FASVTTGLAGDAWHGPASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEATLA
ATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASA
VATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANI
GIGNIGDRNLGIGNTGNWNIGIGITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGT
DSLLPLPNIPLLEYAARFITPVHPGYTATFLETPSQFFPFTGLNSLTYDVSVAQGVTN
LHTAIMAQLAAGNEVVVFGTSQSATIATFEMRYLQSLPAHLRPGLDELSFTLTGNPNR
PDGGILTRFGFSIPQLGFTLSGATPADAYPTVDYAFQYDGVNDFPKYPLNVFATANAI
AGILFLHSGLIALPPDLASGVVQPVSSPDVLTTYILLPSQDLPLLVPLRAIPLLGNPL
ADLIQPDLRVLVELGYDRTAHQDVPSPFGLFPDVDWAEVAADLQQGAVQGVNDALSGL
GLPPPWQPALPRLF"
gene complement(2936810..2937865)
/locus_tag="Rv2609c"
CDS complement(2936810..2937865)
/codon_start=1
/transl_table=11
/locus_tag="Rv2609c"
/product="Probable conserved membrane protein"
/note="Rv2609c, (MTCY01A10.24), len: 351 aa. Probable
conserved membrane protein, equivalent to
O07146|MLCL581.13c|ML0451 hypothetical 37.9 KDA protein
from Mycobacterium leprae (349 aa), FASTA scores: opt:
1675, E(): 1.4e-95, (77.85% identity in 334 aa overlap).
Also similar to hypothetical proteins:
O69888|SC2E1.17|mutt hypothetical 19.4 KDA protein from
Streptomyces coelicolor and Streptomyces lividans (172
aa), FASTA scores: opt: 345,E(): 3.5e-14, (44.7% identity
in 161 aa overlap); Q9L285|SCL2.14c hypothetical 19.8 KDA
protein from Streptomyces coelicolor (180 aa), FASTA
scores: opt: 179,E(): 0.00056, (43.25% identity in 171 aa
overlap); and Q9RYE5|DR0004 mutt/NUDIX family protein from
Deinococcus radiodurans (350 aa), FASTA scores: opt: 153,
E(): 0.037,(33.35% identity in 123 aa overlap). Contains
PS00893 mutT domain signature. Belongs to the mutt/NUDIX
family."
/db_xref="EnsemblGenomes-Gn:Rv2609c"
/db_xref="EnsemblGenomes-Tr:CCP45406"
/db_xref="GOA:I6YDV4"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR020084"
/db_xref="UniProtKB/TrEMBL:I6YDV4"
/inference="protein motif:PROSITE:PS00893"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45406.1"
/translation="MTWLVLAGAVLLVVLVAFGAWGYQTANRLNRLNVRYDLSWQSLD
SALARRAVVARAVAIDAYGGAPQGSRLAALADAAEGAPRHARENAENELSAALAMVNP
ASLPAALIAELADAEARVLLARRFHNDAVRDTLALGERRLVRLLRLGGTAVLPTYFEI
VERPHALVHGDQGASGRRTSARVVLLDDSGAVLLLCGSDPANPAFRDGAAPKWWFTVG
GQVRPGERLAQAAARELAEETGLRVAPADMIGPIWRRDEVFEFNGSLIDSEEFYLVHR
TRRFEPAVQGRTELERRYIRDARWCDANDIAQLVAAGERVYPLQLGELLPAANRLVDV
ALDNGAARDAGVPQPIR"
gene complement(2937865..2939001)
/gene="pimA"
/locus_tag="Rv2610c"
CDS complement(2937865..2939001)
/codon_start=1
/transl_table=11
/gene="pimA"
/locus_tag="Rv2610c"
/product="Alpha-mannosyltransferase PimA"
/note="Rv2610c, (MTCY01A10.23), len: 378 aa.
PimA,alpha-mannosyltransferase (see citations below),
equivalent to O07147|MLCL581.14c|ML0452 putative
glycosyltransferase from Mycobacterium leprae (374 aa),
FASTA scores: opt: 2044, E(): 8.8e-118, (82.25% identity
in 378 aa overlap). N-terminus (from aa 1 to 27)
equivalent to Q9FY7 putative alpha-mannosyl transferase
(fragment) from Mycobacterium smegmatis (27 aa), blastp
scores: 57.4 bits (137), E(): 3e-8, Identities = 25/27
(92%), Positives = 27/27 (99%) (see citation below). Also
highly similar to Q9L284|SCL2.15c putative sugar
transferase from Streptomyces coelicolor (387 aa), FASTA
scores: opt: 1222,E(): 1.8e-67, (52.95% identity in 376 aa
overlap); and similar in part to various proteins e.g.
Q9YA73|APE2066 long hypothetical
N-acetylglucosaminyl-phosphatidylinositol biosynthetic
protein from Aeropyrum pernix (392 aa), FASTA scores: opt:
434, E(): 3e-19, (31.5% identity in 378 aa overlap);
Q9UZA1|PAB0827 galactosyltransferase or LPS biosynthesis
RFBU related protein from Pyrococcus abyssi (371 aa),
FASTA scores: opt: 382, E(): 4.3e-16, (28.2% identity in
383 aa overlap); O26275|MTH173 LPS biosynthesis RFBU
related protein from Methanothermobacter
thermautotrophicus (382 aa), FASTA scores: opt: 372, E():
1.8e-15, (28.4% identity in 391 aa overlap); etc. Shows
also some similarity with O05313|Rv1212c|MTCI364.24c
hypothetical 41.5 KDA protein from Mycobacterium
tuberculosis (387 aa), FASTA scores: opt: 232, E(): 1.1e
-07, (28.4% identity in 402 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2610c"
/db_xref="EnsemblGenomes-Tr:CCP45407"
/db_xref="GOA:P9WMZ5"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/Swiss-Prot:P9WMZ5"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45407.1"
/translation="MRIGMICPYSFDVPGGVQSHVLQLAEVMRTRGHLVSVLAPASPH
AALPDYFVSGGRAVPIPYNGSVARLRFGPATHRKVKKWLAHGDFDVLHLHEPNAPSLS
MLALNIAEGPIVATFHTSTTKSLTLTVFQGILRPMHEKIVGRIAVSDLARRWQMEALG
SDAVEIPNGVDVDSFASAARLDGYPRQGKTVLFLGRYDEPRKGMAVLLDALPKVVQRF
PDVQLLIVGHGDADQLRGQAGRLAAHLRFLGQVDDAGKASAMRSADVYCAPNTGGESF
GIVLVEAMAAGTAVVASDLDAFRRVLRDGEVGHLVPVDPPDLQAAALADGLIAVLEND
VLRERYVAAGNAAVRRYDWSVVASQIMRVYETVAGSGAKVQVAS"
gene complement(2939012..2939962)
/locus_tag="Rv2611c"
CDS complement(2939012..2939962)
/codon_start=1
/transl_table=11
/locus_tag="Rv2611c"
/product="Probable acyltransferase"
/note="Rv2611c, (MTCY01A10.22), len: 316 aa. Probable
acyltransferase , equivalent to O07148|MLCL581.15c|ML0453
hypothetical 35.4 KDA protein from Mycobacterium leprae
(320 aa), FASTA scores: opt: 1529, E(): 5e-90, (71.45%
identity in 312 aa overlap); and equivalent to Q9F7Y8
putative acyltransferase from Mycobacterium smegmatis (303
aa), FASTA scores: opt: 1464, E(): 6.5e-86, (72.15%
identity in 291 aa overlap) (see citation below). Also
highly similar to Q9L283|SCL2.16c putative acyltransferase
from Streptomyces coelicolor (311 aa), FASTA scores: opt:
810, E(): 2.8e-44, (47.7% identity in 302 aa overlap); and
similar to other acyltransferases e.g. Q9F0N3
acyltransferase from Campylobacter jejuni (295 aa), FASTA
scores: opt: 207, E(): 6.4e-06, (20.45% identity in 220 aa
overlap); Q9K379 acyltransferase (lipid a biosynthesis
acyltransferase) from Campylobacter jejuni (295 aa), FASTA
scores: opt: 203, E(): 1.1e-05, (20.0% identity in 220 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2611c"
/db_xref="EnsemblGenomes-Tr:CCP45408"
/db_xref="GOA:P9WMB5"
/db_xref="InterPro:IPR004960"
/db_xref="UniProtKB/Swiss-Prot:P9WMB5"
/protein_id="CCP45408.1"
/translation="MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRN
AFDTGARYFARHGGPEQLRKNLARVLGVPPAAVPDPLMCASLESYGRYWREVFRLPTI
NHRKLARQLDRVIGGLDHLDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAE
RLKPESLYQRFIDYRESLGFEVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTG
VEVDFFGEPTRMPVGPAKLAVETGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAIT
QALADRFAQNIAAHPADWHMLQPQWLADLSESRRAQLRSR"
gene complement(2939959..2940612)
/gene="pgsA1"
/gene_synonym="pgsA"
/locus_tag="Rv2612c"
CDS complement(2939959..2940612)
/codon_start=1
/transl_table=11
/gene="pgsA1"
/gene_synonym="pgsA"
/locus_tag="Rv2612c"
/product="PI synthase PgsA1 (phosphatidylinositol
synthase) (CDP-diacylglycerol--inositol-3-
phosphatidyltransferase)"
/note="Rv2612c, (MTCY01A10.21), len: 217 aa. pgsA1
(previously known as pgsA), PI
synthase/CDP-diacylglyceride--inositol
phosphatidyltransferase, transmembrane protein, equivalent
to O07149|MLCL581.16c|PGSA|ML0454 putative
phosphatidyltransferase from Mycobacterium leprae (239
aa),FASTA scores: opt: 1141, E(): 4.1e-70, (79.35%
identity in 213 aa overlap); and Q9F7Y9|PGSA
phosphatidylinositol synthase from Mycobacterium smegmatis
(222 aa), FASTA scores: opt: 981, E(): 2.7e-59, (67.3%
identity in 217 aa overlap) (see citation below). Also
similar to other proteins e.g. Q9L282|SCL2.17c putative
membrane transferase from Streptomyces coelicolor (241
aa), FASTA scores: opt: 564, E(): 4.9e-31, (43.4% identity
in 212 aa overlap); Q9UYD0|PGSA-like|PAB1041
CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase from Pyrococcus abyssi (186
aa),FASTA scores: opt: 264, E(): 8.4e-11, (33.15% identity
in 190 aa overlap); Q9HQS2|PGSA|VNG1030G
CDP-diacylglycerol-glycerol-3-phosphate
3-phosphatidyltransferase from Halobacterium sp. strain
NRC-1 (199 aa), FASTA scores: opt: 249, E():
9.1e-10,(32.1% identity in 193 aa overlap); etc. Contains
PS00379 CDP-alcohol phosphatidyltransferases signature.
Belongs to the CDP-alcohol phosphatidyltransferase class-I
family. Note that in Mycobacterium smegmatis, the psgA
homologue is essential to the survival of the bacteria and
seems cannot be compensated by any other enzyme of
Mycobacterium smegmatis."
/db_xref="EnsemblGenomes-Gn:Rv2612c"
/db_xref="EnsemblGenomes-Tr:CCP45409"
/db_xref="GOA:P9WPG7"
/db_xref="InterPro:IPR000462"
/db_xref="PDB:6H59"
/db_xref="PDB:6H5A"
/db_xref="UniProtKB/Swiss-Prot:P9WPG7"
/inference="protein motif:PROSITE:PS00379"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45409.1"
/translation="MSKLPFLSRAAFARITTPIARGLLRVGLTPDVVTILGTTASVAG
ALTLFPMGKLFAGACVVWFFVLFDMLDGAMARERGGGTRFGAVLDATCDRISDGAVFC
GLLWWIAFHMRDRPLVIATLICLVTSQVISYIKARAEASGLRGDGGFIERPERLIIVL
TGAGVSDFPFVPWPPALSVGMWLLAVASVITCVQRLHTVWTSPGAIDRMAIPGKGDR"
gene complement(2940609..2941196)
/locus_tag="Rv2613c"
CDS complement(2940609..2941196)
/codon_start=1
/transl_table=11
/locus_tag="Rv2613c"
/product="Conserved protein"
/note="Rv2613c, (MTCY01A10.20A), len: 195 aa. Conserved
protein, equivalent to Q9CCU0|ML0455 hypothetical protein
from Mycobacterium leprae (206 aa), FASTA scores: opt:
1074, E(): 7.4e-62, (84.7% identity in 196 aa overlap);
and highly similar, but longer 18 aa, to
O07150|MLCL581.17c hypothetical 20.7 KDA protein from
Mycobacterium leprae (186 aa), FASTA scores: opt: 1038,
E(): 1.4e-59, (89.7% identity in 175 aa overlap). Also
highly similar to other hypothetical proteins (often Hit
family member) e.g. Q9F7Z0 from Mycobacterium smegmatis
(see citation below) (205 aa),FASTA scores: opt: 975, E():
1.6e-55, (79.35% identity in 184 aa overlap);
Q9L279|SCL2.20 from Streptomyces coelicolor (186 aa),
FASTA scores: opt: 638, E(): 5.8e-34,(52.85% identity in
176 aa overlap); Q9YFX8|APE0122 from Aeropyrum pernix (184
aa), FASTA scores: opt: 515, E(): 4.4e-26, (45.9% identity
in 159 aa overlap); etc. It seems the Rv2613c and
downstream ORF Rv2612c|psgA1 are expressed from the same
promoter (see citation below) and that Rv2613c should be
involved in lipid metabolism."
/db_xref="EnsemblGenomes-Gn:Rv2613c"
/db_xref="EnsemblGenomes-Tr:CCP45410"
/db_xref="GOA:P9WMK9"
/db_xref="InterPro:IPR001310"
/db_xref="InterPro:IPR011146"
/db_xref="InterPro:IPR036265"
/db_xref="InterPro:IPR039383"
/db_xref="PDB:3ANO"
/db_xref="PDB:3WO5"
/db_xref="UniProtKB/Swiss-Prot:P9WMK9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45410.1"
/translation="MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPV
KRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSE
LEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRW
GGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP"
gene complement(2941189..2943267)
/gene="thrS"
/locus_tag="Rv2614c"
CDS complement(2941189..2943267)
/codon_start=1
/transl_table=11
/gene="thrS"
/locus_tag="Rv2614c"
/product="Probable threonyl-tRNA synthetase ThrS
(threonine-tRNA synthetase)(ThrRS) (threonine-tRNA
ligase)"
/note="Rv2614c, (MT2689, MTCY01A10.20), len: 692 aa.
Probable thrS, threonyl-tRNA synthetase (Threonine--tRNA
ligase), equivalent to
O07151|SYT_MYCLE|THRS|ML0456|MLCL581.18c threonyl-tRNA
synthetase from Mycobacterium leprae (702 aa), FASTA
scores: opt: 3988, E(): 0, (84.05% identity in 702 aa
overlap). Also highly similar to others e.g. Q9L278|THRS
from Streptomyces coelicolor (658 aa), FASTA scores: opt:
1982, E(): 5.1e-114, (65.1% identity in 659 aa overlap);
P56881|SYT_THETH|THRS from Thermus aquaticus (subsp.
thermophilus) (659 aa), FASTA scores: opt: 1551, E():
1.5e-87, (46.5% identity in 650 aa overlap);
P00955|SYT_ECOLI from Escherichia coli (642 aa), FASTA
scores: opt: 946, E(): 0, (40.7% identity in 612 aa overl
ap); etc. Contains PS00339 Aminoacyl-transfer RNA
synthetases class-II signature 2. Belongs to class-II
aminoacyl-tRNA synthetase family. Cofactor: binds 1 zinc
ion (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv2614c"
/db_xref="EnsemblGenomes-Tr:CCP45411"
/db_xref="GOA:P9WFT5"
/db_xref="InterPro:IPR002314"
/db_xref="InterPro:IPR002320"
/db_xref="InterPro:IPR004154"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR012947"
/db_xref="InterPro:IPR018163"
/db_xref="InterPro:IPR033728"
/db_xref="InterPro:IPR036621"
/db_xref="UniProtKB/Swiss-Prot:P9WFT5"
/inference="protein motif:PROSITE:PS00339"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45411.1"
/translation="MSAPAQPAPGVDGGDPSQARIRVPAGTTAATAVGEAGLPRRGTP
DAIVVVRDADGNLRDLSWVPDVDTDITPVAANTDDGRSVIRHSTAHVLAQAVQELFPQ
AKLGIGPPITDGFYYDFDVPEPFTPEDLAALEKRMRQIVKEGQLFDRRVYESTEQARA
ELANEPYKLELVDDKSGDAEIMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTKH
IPAFKLTRSSAAYWRGDQKNASLQRIYGTAWESQEALDRHLEFIEEAQRRDHRKLGVE
LDLFSFPDEIGSGLAVFHPKGGIVRRELEDYSRRKHTEAGYQFVNSPHITKAQLFHTS
GHLDWYADGMFPPMHIDAEYNADGSLRKPGQDYYLKPMNCPMHCLIFRARGRSYRELP
LRLFEFGTVYRYEKSGVVHGLTRVRGLTMDDAHIFCTRDQMRDELRSLLRFVLDLLAD
YGLTDFYLELSTKDPEKFVGAEEVWEEATTVLAEVGAESGLELVPDPGGAAFYGPKIS
VQVKDALGRTWQMSTIQLDFNFPERFGLEYTAADGTRHRPVMIHRALFGSIERFFGIL
TEHYAGAFPAWLAPVQVVGIPVADEHVAYLEEVATQLKSHGVRAEVDASDDRMAKKIV
HHTNHKVPFMVLAGDRDVAAGAVSFRFGDRTQINGVARDDAVAAIVAWIADRENAVPT
AELVKVAGRE"
gene 2943376..2943603
/locus_tag="Rv2614A"
CDS 2943376..2943603
/codon_start=1
/transl_table=11
/locus_tag="Rv2614A"
/product="Conserved hypothetical protein"
/note="Rv2614A, len: 75 aa. Conserved hypothetical
protein. The region from aa 10-35 is similar to part of
C-terminal part of several triosephosphate isomerases e.g.
P46711|TPIS_MYCLE|TPIA|TPI|ML0572|B1496_C1_127 from
Mycobacterium leprae (261 aa), FASTA scores: opt: 112,
E(): 0.95, (60.0% identity in 25 aa overlap); and
O08408|TPIS_MYCTU|TPIA|TPI|Rv1438|MT1482|MTCY493.16c from
Mycobacterium tuberculosis (261 aa), FASTA scores: opt:
104, E(): 3.3, (60.0% identity in 25 aa overlap);
P19583|TPIS_CORGL|TPIA|TPI from Corynebacterium glutamicum
(Brevibacterium flavum) (259 aa), FASTA scores: opt:
100,E(): 6, (45.45% identity in 33 aa overlap); etc.
Triosephosphate isomerases play an important role in
several metabolic pathways (catalytic activity:
D-glyceraldehyde 3-phosphate = dihydroxy-acetone
phosphate). Nucleotide position 2943411 in the genome
sequence has been corrected, T:C resulting in L12L."
/db_xref="EnsemblGenomes-Gn:Rv2614A"
/db_xref="EnsemblGenomes-Tr:CCP45412"
/db_xref="UniProtKB/TrEMBL:Q79FC4"
/protein_id="CCP45412.1"
/translation="MGDRYRAGDRVLYGGSMSPKDVDDLATQQDVDDGQSIERRWTGS
GQRRWRRSPPTGRYRSNSQIQVWISGAGRLR"
gene complement(2943600..2944985)
/gene="PE_PGRS45"
/locus_tag="Rv2615c"
CDS complement(2943600..2944985)
/codon_start=1
/transl_table=11
/gene="PE_PGRS45"
/locus_tag="Rv2615c"
/product="PE-PGRS family protein PE_PGRS45"
/note="Rv2615c, (MTCY01A10.19), len: 461 aa.
PE_PGRS45,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to many e.g.
P71664|Rv1396c|MTCY21B4.13c from Mycobacterium
tuberculosis (576 aa), FASTA scores: opt: 1629, E():
4.8e-58, (56.65% identity in 482 aa overlap). Equivalent
to AAK47006 from Mycobacterium tuberculosis strain CDC1551
(476 aa) but shorter 15 aa."
/db_xref="EnsemblGenomes-Gn:Rv2615c"
/db_xref="EnsemblGenomes-Tr:CCP45413"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FC3"
/protein_id="CCP45413.1"
/translation="MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQD
EVSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLD
AINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAG
LIGNGGAGGAGGQGLPFEAGANGGAGGAGGWLFGNGGAGGNGGIGGAGTNLAIGGHGG
NGGNAGLIGAGGTGGAGGTGGGEPSAGASGGNGGNGGNGGLLIGNSGDGGAAGNGAGI
SQNGPASGFGGNGGHAGTTGLIGNGGNGGAGGAGGDVSADFGGVGFGGQGGNGGAGGL
LYGNGGAGGNGGAAGSPGSVTAFGGNGGSGGSGGNGGNALIGNAGAGGSAGAGGNGAS
AGTAGGSGGDGGKGGNGGSVGLIGNGGNGGNGGAGSLFNGAPGFGGPGGSGGASLLGP
PGLAGTNGADG"
gene 2945330..2945830
/locus_tag="Rv2616"
CDS 2945330..2945830
/codon_start=1
/transl_table=11
/locus_tag="Rv2616"
/product="Conserved protein"
/note="Rv2616, (MTCY01A10.18c), len: 166 aa. Conserved
protein, highly similar to bacterial proteins:
Q9L1G0|SC3D11.02c hypothetical 20.3 KDA protein from
Streptomyces coelicolor (188 aa), FASTA scores: opt:
407,E(): 2.3e-20, (44.0% identity in 159 aa overlap);
Q9X945 A3(2) glycogen metabolism cluster from Streptomyces
coelicolor (134 aa), FASTA scores: opt: 330, E():
2.5e-15,(46.65% identity in 120 aa overlap) (N-terminus
shorter); Q9RST8|DR2035 conserved hypothetical protein
from Deinococcus radiodurans (198 aa), FASTA scores: opt:
228,E(): 2.4e-08, (35.1% identity in 168 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2616"
/db_xref="EnsemblGenomes-Tr:CCP45414"
/db_xref="GOA:O06198"
/db_xref="InterPro:IPR014457"
/db_xref="InterPro:IPR018960"
/db_xref="UniProtKB/TrEMBL:O06198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45414.1"
/translation="MDLNALADLPLTYPEVGATATGRLPAGYNHLDVSTQIGTGRQRF
EQAADAVMHWGMQRNAGLRVRASSETAVVSAVVLVGIAFLRAPCRVVYVIDEPDVRGF
GYGTLPGHPVSGEERFAVRCDPMTSVVFAEVLSFSRPATWASKAAGPLGAVTQRFIAQ
RYLRAV"
gene complement(2945847..2946287)
/locus_tag="Rv2617c"
CDS complement(2945847..2946287)
/codon_start=1
/transl_table=11
/locus_tag="Rv2617c"
/product="Probable transmembrane protein"
/note="Rv2617c, (MTCY01A10.17), len: 146 aa. Probable
transmembrane protein, showing some similarity to
hypothetical or membrane proteins e.g. CAC47207|SMC00744
putative transport protein transmembrane from Rhizobium
meliloti (Sinorhizobium meliloti) (399 aa), FASTA scores:
opt: 108, E(): 5.5, (29.15% identity in 144 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2617c"
/db_xref="EnsemblGenomes-Tr:CCP45415"
/db_xref="GOA:I6XER9"
/db_xref="InterPro:IPR032808"
/db_xref="UniProtKB/TrEMBL:I6XER9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45415.1"
/translation="MSIRPTTSPALADQLKDPAYSAYVLLRTLFTVAPILFGLDKFFN
LLTHPQHWNMYLAGWINDLVPGTADQCMYLVGAIEIVAGVLVAVAPRIGAWVVAAWLA
GIILNLVTGPGFYDIALRDFGLLVGAIALARLAQGVHSGGIGRP"
gene 2946434..2947111
/locus_tag="Rv2618"
CDS 2946434..2947111
/codon_start=1
/transl_table=11
/locus_tag="Rv2618"
/product="Conserved hypothetical protein"
/note="Rv2618, (MTCY01A10.15c), len: 225 aa. Conserved
hypothetical protein, similar in part to Q9EWQ9|SC4C2.03
conserved hypothetical protein from Streptomyces
coelicolor (159 aa), FASTA scores: opt: 235, E(): 1.3e-07,
(43.7% identity in 103 aa overlap); Q9HLM6|TA0201
hypothetical protein from Thermoplasma acidophilum (215
aa), FASTA scores: opt: 164, E(): 0.0038, (23.4% identity
in 201 aa overlap); and to mycobacterial proteins e.g.
O06191|Rv2621c|MTCY01A10.11 hypothetical 24.2 KDA protein
from Mycobacterium tuberculosis (224 aa), FASTA scores:
opt: 149, E(): 0.033, (28.05% identity in 196 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2618"
/db_xref="EnsemblGenomes-Tr:CCP45416"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O06195"
/protein_id="CCP45416.1"
/translation="MDPVRRQLYQFVCSQSMPVSRDQAADAVGIPRHQAKFHLDRLTA
EGLLDTEYARLTGRSGPGAGRTAKLYRRAGRDIALSLPQREYELAGRLMAAAIVLSAT
TGEPTVEVLNRIAHDYGQAMGAAATTRPPADPAAALELTLDVLRKYGYEPRRPAGPGD
DEVELVNCPFHALAREQTELACNMNHALITGVADALAPHSPAVRLAPGPARCCVVLKR
CSAHDPE"
gene complement(2947096..2947449)
/locus_tag="Rv2619c"
CDS complement(2947096..2947449)
/codon_start=1
/transl_table=11
/locus_tag="Rv2619c"
/product="Conserved protein"
/note="Rv2619c, (MTCY01A10.14), len: 117 aa. Conserved
protein, highly similar to Q9L0F3|SCD31.14 hypothetical
11.6 KDA protein from Streptomyces coelicolor (110
aa),FASTA scores: opt: 407, E(): 2.3e-21, (55.95% identity
in 109 aa overlap). Also similarity with other short
bacterial hypothetical proteins e.g. Q9F8B9 hypothetical
12.4 KDA protein from Streptococcus agalactiae (112 aa),
FASTA scores: opt: 143, E(): 0.0032, (32.45% identity in
74 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2619c"
/db_xref="EnsemblGenomes-Tr:CCP45417"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR014710"
/db_xref="UniProtKB/TrEMBL:O06194"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45417.1"
/translation="MESISLTSLAAEKLAEAQQTHSGRAAHTIHGGHTHELRQTVLAL
LAGHDLSEHDSPGEATLQVLQGHVCLTAGEDAWNGRAGDYVAIPPTRHALHAVEDSVI
MLTVLKSLPDAHSGS"
gene complement(2947462..2947887)
/locus_tag="Rv2620c"
CDS complement(2947462..2947887)
/codon_start=1
/transl_table=11
/locus_tag="Rv2620c"
/product="Probable conserved transmembrane protein"
/note="Rv2620c, (MTCY01A10.13), len: 141 aa. Probable
conserved transmembrane protein, highly similar to
O54184|SC7H1.25 hypothetical 14.6 KDA protein from
Streptomyces coelicolor (144 aa), FASTA scores: opt:
459,E(): 1.4e-22, (56.45% identity in 140 aa overlap).
Predicted possible vaccine candidate (See Zvi et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv2620c"
/db_xref="EnsemblGenomes-Tr:CCP45418"
/db_xref="GOA:I6Y9U6"
/db_xref="UniProtKB/TrEMBL:I6Y9U6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45418.1"
/translation="MSAGPAIEVAVAFVWLGMVVAISFLEAPLKFRAAGVTLQIGLGI
GRLVFRALNTVEVGFALVILAIVVVGSTPARIAAAFSVALAALAVQLIAVRPRLTRRS
NQVLAGLQAPRSRGHHIYVGLEIVKVVALLVAGILLLNG"
gene complement(2947884..2948558)
/locus_tag="Rv2621c"
CDS complement(2947884..2948558)
/codon_start=1
/transl_table=11
/locus_tag="Rv2621c"
/product="Possible transcriptional regulatory protein"
/note="Rv2621c, (MTCY01A10.11), len: 224 aa. Possible
transcriptional regulator, similar in part to
Q49688|MLCL536.29c|ML0592 putative DNA-binding protein
from Mycobacterium leprae (254 aa), FASTA scores: opt:
168, E(): 0.0018, (29.75% identity in 222 aa overlap).
Shows similarity with Q9XAD0|SCC22.08c putative
DNA-binding protein from Streptomyces coelicolor (252 aa),
FASTA scores: opt: 148, E(): 0.032, (29.4% identity in 204
aa overlap); and Q9RVM8|DR0999 conserved hypothetical
protein from Deinococcus radiodurans (225 aa), FASTA
scores: opt: 195, E(): 3.3e-05, (29.6% identity in 213 aa
overlap). Also some similarity with
O06195|Rv2618|MTCY01A10.15c from Mycobacterium
tuberculosis (225 aa), FASTA scores: opt: 149, E(): 0.025,
(28.95% identity in 197 aa overlap). Contains
helix-turn-helix motif at aa 31-52 (Score 1662,+4.85 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2621c"
/db_xref="EnsemblGenomes-Tr:CCP45419"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:I6Y187"
/protein_id="CCP45419.1"
/translation="MGVSVIIRSLQEPVGRRRAVLRALCASRVPMSIAAIAGKLGVHP
NTVRFHLDNLVADGQVERVEPGRGRPGRPPLMFRAVRRTDSTGTRRYRLLAEILASGL
AAERDSRAMALSAGRAWGRQLEAPPAGADTEETIDHLVAVLDDLGFAPERRASNGRQQ
VGLRHCPFLELAETQAGVVCPVHLGIMRGALQTWGAPVTVDRLDAFVEPDLCLAHFTP
LEGAIR"
gene 2948636..2949457
/locus_tag="Rv2622"
CDS 2948636..2949457
/codon_start=1
/transl_table=11
/locus_tag="Rv2622"
/product="Possible methyltransferase (methylase)"
/note="Rv2622, (MTCY01A10.10c), len: 273 aa. Possible
methyltransferase, similar in part to others e.g.
AAK75664|SP1578 putative methyltransferase from
Streptococcus pneumoniae (252 aa), FASTA scores: opt:
406,E(): 6.6e-18, (32.65% identity in 251 aa overlap);
Q9F8B8 methyltransferase from Streptococcus agalactiae
(254 aa),FASTA scores: opt: 381, E(): 2.3e-16, (31.75%
identity in 252 aa overlap); Q9RJB6|SCF91.08 putative
methyltransferase from Streptomyces coelicolor (231 aa),
FASTA scores: opt: 159, E(): 0.0091, (33.1% identity in
151 aa overlap); etc. Also similar in part to several
hypothetical proteins e.g. Q99YR0|SPY1582 hypothetical
protein from Streptococcus pyogenes (251 aa), FASTA
scores: opt: 397, E(): 2.3e-17,(36.3% identity in 248 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2622"
/db_xref="EnsemblGenomes-Tr:CCP45420"
/db_xref="GOA:I6XES4"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:I6XES4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45420.1"
/translation="MANKRGNAGQPLPLSDRDDDHMQGHWLLARLGKRVLRPGGVELT
RTLLARAEVTDADVLELAPGLGRTAAEILARNPRSYVGAESDPNAANLVRHVLAGRGD
VRVTDAADTGLSDASADVVIGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALV
PDDVAEQVRTDLRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPRR
VIADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAHKPHVDS"
gene 2949593..2950486
/gene="TB31.7"
/locus_tag="Rv2623"
CDS 2949593..2950486
/codon_start=1
/transl_table=11
/gene="TB31.7"
/locus_tag="Rv2623"
/product="Universal stress protein family protein TB31.7"
/note="Rv2623, (MTCY01A10.09c), len: 297 aa.
TB31.7,universal stress protein family protein, highly
similar to hypothetical proteins from Mycobacterium
tuberculosis e.g. Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.
12 (295 aa), FASTA scores: opt: 1076, E(): 1.4e-60,
(55.25% identity in 295 aa overlap);
O53472|Rv2026c|MTV018.13c (294 aa), FASTA scores: opt:
988, E(): 4.8e-55, (51.5% identity in 295 aa overlap);
Q10862|YJ96_MYCTU|Rv1996|MT2052|MTCY39.23c (317 aa), FASTA
scores: opt: 688, E(): 4.1e-36, (45.1% identity in 315 aa
overlap); etc. Also similar to several Streptomyces
proteins e.g. Q9RIZ8|SCJ1.16c conserved hypothetical
protein from Streptomyces coelicolor (294 aa), FASTA
scores: opt: 407, E(): 2e-18, (32.65% identity in 303 aa
overlap); and other bacterial hypothetical proteins e.g.
Q9HPP5|VNG1536 from Halobacterium sp (147 aa), FASTA
scores: opt: 180, E(): 0.00022, (31.65% identity in 139 aa
overlap). Predicted possible vaccine candidate (See Zvi et
al., 2008). Binds ATP."
/db_xref="EnsemblGenomes-Gn:Rv2623"
/db_xref="EnsemblGenomes-Tr:CCP45421"
/db_xref="GOA:P9WFD7"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="PDB:2JAX"
/db_xref="PDB:3CIS"
/db_xref="UniProtKB/Swiss-Prot:P9WFD7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45421.1"
/translation="MSSGNSSLGIIVGIDDSPAAQVAVRWAARDAELRKIPLTLVHAV
SPEVATWLEVPLPPGVLRWQQDHGRHLIDDALKVVEQASLRAGPPTVHSEIVPAAAVP
TLVDMSKDAVLMVVGCLGSGRWPGRLLGSVSSGLLRHAHCPVVIIHDEDSVMPHPQQA
PVLVGVDGSSASELATAIAFDEASRRNVDLVALHAWSDVDVSEWPGIDWPATQSMAEQ
VLAERLAGWQERYPNVAITRVVVRDQPARQLVQRSEEAQLVVVGSRGRGGYAGMLVGS
VGETVAQLARTPVIVARESLT"
gene complement(2950489..2951307)
/locus_tag="Rv2624c"
CDS complement(2950489..2951307)
/codon_start=1
/transl_table=11
/locus_tag="Rv2624c"
/product="Universal stress protein family protein"
/note="Rv2624c, (MTCY01A10.08), len: 272 aa. Universal
stress protein family protein, similar to several
Streptomyces proteins e.g. Q9RIY5|SCJ1.29c hypothetical
30.1 KDA protein from Streptomyces coelicolor (283
aa),FASTA scores: opt: 260, E(): 5e-09, (32.05% identity
in 290 aa overlap). Also similar to Mycobacterium
tuberculosis proteins O53474|Rv2028c|MTV018.15c (279 aa),
FASTA scores: opt: 563, E(): 7e-28, (36.85% identity in
266 aa overlap); P95192|Rv3134c|MTCY03A2.240 (268 aa),
FASTA scores: opt: 458, E(): 2.3e-21, (36.55% identity in
271 aa overlap); Q10851|YK05_MYCTU|Rv2005c|MT2061|MTCY39.1
2 (295 aa), FASTA scores: opt: 199, E(): 3.2e-05, (29.35%
identity in 286 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2624c"
/db_xref="EnsemblGenomes-Tr:CCP45422"
/db_xref="GOA:P9WFD5"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="UniProtKB/Swiss-Prot:P9WFD5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45422.1"
/translation="MSGRGEPTMKTIIVGIDGSHAAITAALWGVDEAISRAVPLRLVS
VIKPTHPSPDDYDRDLAHAERSLREAQSAVEAAGKLVKIETDIPRGPAGPVLVEASRD
AEMICVGSVGIGRYASSILGSTATELAEKAHCPVAVMRSKVDQPASDINWIVVRMTDA
PDNEAVLEYAAREAKLRQAPILALGGRPEELREIPDGEFERRVQDWHHRHPDVRVYPI
TTHTGIARFLADHDERVQLAVIGGGEAGQLARLVGPSGHPVFRHAECSVLVVRR"
gene complement(2951322..2952503)
/locus_tag="Rv2625c"
CDS complement(2951322..2952503)
/codon_start=1
/transl_table=11
/locus_tag="Rv2625c"
/product="Probable conserved transmembrane alanine and
leucine rich protein"
/note="Rv2625c, (MTCY01A10.07), len: 393 aa. Probable
conserved transmembrane ala-, leu-rich protein, similar to
many hypothetical or membrane proteins e.g.
Q55518|Y528_SYNY3|SLL0528 potential integral membrane
protein from Synechocystis sp. strain PCC 6803 (379
aa),FASTA scores: opt: 552, E(): 5.6e-26, (30.75% identity
in 374 aa overlap); Q9RJ56|SCI41.35c hypothetical 39.8 KDA
protein from Streptomyces coelicolor (374 aa), FASTA
scores: opt: 419, E(): 5.7e-18, (31.6% identity in 383 aa
overlap); CAC49448|SMB20925 conserved hypothetical
membrane protein from Rhizobium meliloti (Sinorhizobium
meliloti) (372 aa), FASTA scores: opt: 401, E(): 6.9e-17,
(29.5% identity in 383 aa overlap); etc. Contains PS00142
Neutral zinc metallopeptidases, zinc-binding region
signature."
/db_xref="EnsemblGenomes-Gn:Rv2625c"
/db_xref="EnsemblGenomes-Tr:CCP45423"
/db_xref="GOA:P9WHR1"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR008915"
/db_xref="InterPro:IPR016483"
/db_xref="UniProtKB/Swiss-Prot:P9WHR1"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45423.1"
/translation="MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYP
AVVYWLLGAGGAVMLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTP
KAAFRIAFAGPATSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLP
GAPLDGGRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWL
AFIGWFIFAAAREEETRISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGER
HSAYPVADRDGSITGLVALRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALL
ERMAPLGPRSRALVTEGSAVVGIVTPSDVARLIDVYRLAQPEPTFTTSPQDADRFSDA
G"
gene complement(2952562..2952993)
/gene="hrp1"
/locus_tag="Rv2626c"
CDS complement(2952562..2952993)
/codon_start=1
/transl_table=11
/gene="hrp1"
/locus_tag="Rv2626c"
/product="Hypoxic response protein 1 Hrp1"
/note="Rv2626c, (MTCY01A10.06), len: 143 aa. Hrp1, hypoxic
response protein 1, similar to CAC49670|SMB21441 putative
inosine-5'-monophosphate dehydrogenase protein from
Rhizobium meliloti (Sinorhizobium meliloti) (120 aa),
FASTA scores: opt: 287, E(): 6.6e-12, (43.75% identity in
112 aa overlap) (has its N-terminus shorter 27 aa);
AAK78655|CAC0678 CBS domains from Clostridium
acetobutylicum (142 aa), FASTA scores: opt: 276, E():
3.9e-11, (35.65% identity in 115 aa overlap);
Q9K9P0|BH2605 BH2605 protein from Bacillus halodurans (142
aa), FASTA scores: opt: 276, E(): 3.9e-11, (35.65%
identity in 115 aa overlap); etc. Also some similarity to
P71737|Rv2406c|MTCY253.14 hypothetical 15.1 KDA protein
from Mycobacterium tuberculosis (142 aa), FASTA scores:
opt: 145, E(): 0.00012, (22.3% identity in 112 aa
overlap). Predicted possible vaccine candidate (See Zvi et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv2626c"
/db_xref="EnsemblGenomes-Tr:CCP45424"
/db_xref="GOA:P9WJA3"
/db_xref="InterPro:IPR000644"
/db_xref="PDB:1XKF"
/db_xref="PDB:1Y5H"
/db_xref="UniProtKB/Swiss-Prot:P9WJA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45424.1"
/translation="MTTARDIMNAGVTCVGEHETLTAAAQYMREHDIGALPICGDDDR
LHGMLTDRDIVIKGLAAGLDPNTATAGELARDSIYYVDANASIQEMLNVMEEHQVRRV
PVISEHRLVGIVTEADIARHLPEHAIVQFVKAICSPMALAS"
gene complement(2953507..2954748)
/locus_tag="Rv2627c"
CDS complement(2953507..2954748)
/codon_start=1
/transl_table=11
/locus_tag="Rv2627c"
/product="Conserved protein"
/note="Rv2627c, (MTCY01A10.05), len: 413 aa. Conserved
protein. Some similarity in C-terminal part of
O53697|Rv0293c|MTV035.21c hypothetical 44.0 KDA protein
from Mycobacterium tuberculosis (400 aa), FASTA scores:
opt: 392, E(): 1.9e-17, (31.1% identity in 299 aa
overlap). Alternative nucleotide at position 2954439
(T->C; R104G) has been observed. Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2627c"
/db_xref="EnsemblGenomes-Tr:CCP45425"
/db_xref="GOA:P9WL67"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WL67"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45425.1"
/translation="MASSASDGTHERSAFRLSPPVLSGAMGPFMHTGLYVAQSWRDYL
GQQPDKLPIARPTIALAAQAFRDEIVLLGLKARRPVSNHRVFERISQEVAAGLEFYGN
RRWLEKPSGFFAQPPPLTEVAVRKVKDRRRSFYRIFFDSGFTPHPGEPGSQRWLSYTA
NNREYALLLRHPEPRPWLVCVHGTEMGRAPLDLAVFRAWKLHDELGLNIVMPVLPMHG
PRGQGLPKGAVFPGEDVLDDVHGTAQAVWDIRRLLSWIRSQEEESLIGLNGLSLGGYI
ASLVASLEEGLACAILGVPVADLIELLGRHCGLRHKDPRRHTVKMAEPIGRMISPLSL
TPLVPMPGRFIYAGIADRLVHPREQVTRLWEHWGKPEIVWYPGGHTGFFQSRPVRRFV
QAALEQSGLLDAPRTQRDRSA"
gene 2955058..2955420
/locus_tag="Rv2628"
CDS 2955058..2955420
/codon_start=1
/transl_table=11
/locus_tag="Rv2628"
/product="Hypothetical protein"
/note="Rv2628, (MTCY01A10.04c), len: 120 aa. Hypothetical
unknown protein. Predicted possible vaccine candidate (See
Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2628"
/db_xref="EnsemblGenomes-Tr:CCP45426"
/db_xref="UniProtKB/Swiss-Prot:P9WL65"
/protein_id="CCP45426.1"
/translation="MSTQRPRHSGIRAVGPYAWAGRCGRIGRWGVHQEAMMNLAIWHP
RKVQSATIYQVTDRSHDGRTARVPGDEITSTVSGWLSELGTQSPLADELARAVRIGDW
PAAYAIGEHLSVEIAVAV"
gene 2955767..2956891
/locus_tag="Rv2629"
CDS 2955767..2956891
/codon_start=1
/transl_table=11
/locus_tag="Rv2629"
/product="Conserved protein"
/note="Rv2629, (MTCY01A10.03c), len: 374 aa. Conserved
protein, similar to Q9ZC00|SC1E6.22c hypothetical 40.7 KDA
protein from Streptomyces coelicolor (373 aa), FASTA
scores: opt: 425, E(): 2.5e-18, (30.2% identity in 371 aa
overlap). Predicted possible vaccine candidate (See Zvi et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2629"
/db_xref="EnsemblGenomes-Tr:CCP45427"
/db_xref="GOA:P9WL63"
/db_xref="InterPro:IPR029064"
/db_xref="InterPro:IPR040701"
/db_xref="UniProtKB/Swiss-Prot:P9WL63"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45427.1"
/translation="MRSERLRWLVAAEGPFASVYFDDSHDTLDAVERREATWRDVRKH
LESRDAKQELIDSLEEAVRDSRPAVGQRGRALIATGEQVLVNEHLIGPPPATVIRLSD
YPYVVPLIDLEMRRPTYVFAAVDHTGADVKLYQGATISSTKIDGVGYPVHKPVTAGWN
GYGDFQHTTEEAIRMNCRAVADHLTRLVDAADPEVVFVSGEVRSRTDLLSTLPQRVAV
RVSQLHAGPRKSALDEEEIWDLTSAEFTRRRYAEITNVAQQFEAEIGRGSGLAAQGLA
EVCAALRDGDVDTLIVGELGEATVVTGKARTTVARDADMLSELGEPVDRVARADEALP
FAAIAVGAALVRDDNRIAPLDGVGALLRYAATNRLGSHRS"
gene 2956893..2957432
/locus_tag="Rv2630"
CDS 2956893..2957432
/codon_start=1
/transl_table=11
/locus_tag="Rv2630"
/product="Hypothetical protein"
/note="Rv2630, (MTCY01A10.02c), len: 179 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2630"
/db_xref="EnsemblGenomes-Tr:CCP45428"
/db_xref="GOA:P9WQ03"
/db_xref="InterPro:IPR023572"
/db_xref="InterPro:IPR036820"
/db_xref="UniProtKB/Swiss-Prot:P9WQ03"
/protein_id="CCP45428.1"
/translation="MLHRDDHINPPRPRGLDVPCARLRATNPLRALARCVQAGKPGTS
SGHRSVPHTADLRIEAWAPTRDGCIRQAVLGTVESFLDLESAHAVHTRLRRLTADRDD
DLLVAVLEEVIYLLDTVGETPVDLRLRDVDGGVDVTFATTDASTLVQVGAVPKAVSLN
ELRFSQGRHGWRCAVTLDV"
gene 2957572..2958870
/locus_tag="Rv2631"
CDS 2957572..2958870
/codon_start=1
/transl_table=11
/locus_tag="Rv2631"
/product="Conserved hypothetical protein"
/note="Rv2631, (MTCY441.01, MTCY01A10.01c), len: 432 aa.
Conserved hypothetical protein, highly similar to several
conserved hypothetical proteins from various species e.g.
O29399|AF0862 conserved hypothetical protein from
Archaeoglobus fulgidus (482 aa), FASTA scores: opt:
1496,E(): 2.1e-80, (52.3% identity in 432 aa overlap) (has
its N-terminus longer 30 aa); O27634|MTH1597 conserved
protein from Methanothermobacter thermautotrophicus (488
aa), FASTA scores: opt: 1428, E(): 2.1e-76, (50.9%
identity in 432 aa overlap); Q9YB37|APE1758 hypothetical
53.7 KDA protein APE1758 from Aeropyrum pernix (483 aa),
FASTA scores: opt: 1422, E(): 4.6e-76, (49.3% identity in
432 aa overlap) (has its N-terminus longer 30 aa); etc.
Equivalent to AAK47022 from Mycobacterium tuberculosis
strain CDC1551 (432 aa). 3' part extended since first
submission (+175 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2631"
/db_xref="EnsemblGenomes-Tr:CCP45429"
/db_xref="GOA:P9WGW5"
/db_xref="InterPro:IPR001233"
/db_xref="InterPro:IPR036025"
/db_xref="UniProtKB/Swiss-Prot:P9WGW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45429.1"
/translation="MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVV
SPGGVGFDISCGVRLLVGEGLDREELQPRLPAVMDRLDRAIPRGVGTAGVWRLPDRNT
LQEVLTGGARFAVEQGHGVALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSG
NHFLEVQAVDRVYDPVAAAPMGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRY
GIAVPDRQLACVPVHSPDGQAYLAAMAAAANYGRANRQLLTEATRRVFADATGTPLDL
LYDVSHNLAKIETHPIDGQLRSVCVHRKGATRSLPPHHHELPAELAAVGQPVLIPGTM
GTASYVLAGVTGNPAFFSTAHGAGRVLSRHQAARHTSGEAIRASLAKRGIIVRGTSRR
GIAEEKPEAYKDVDEVIEASHQSGLARKVARLVPLGCVKG"
gene complement(2958909..2959190)
/locus_tag="Rv2632c"
CDS complement(2958909..2959190)
/codon_start=1
/transl_table=11
/locus_tag="Rv2632c"
/product="Conserved protein"
/note="Rv2632c, (MTCY441.02c), len: 93 aa. Conserved
protein, highly similar to conserved hypothetical proteins
from Mycobacterium tuberculosis:
P71996|YH38_MYCTU|Rv1738|MT1780|MTCY04C12.23 (94 aa),
FASTA scores: opt: 319, E(): 4.2e-15, (53.95% identity in
89 aa overlap); and Q9KK61 from Mycobacterium bovis BCG
(56 aa),FASTA scores: opt: 178, E(): 9.2e-06, (52.95%
identity in 51 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2632c"
/db_xref="EnsemblGenomes-Tr:CCP45430"
/db_xref="InterPro:IPR015057"
/db_xref="InterPro:IPR038070"
/db_xref="PDB:2FGG"
/db_xref="UniProtKB/Swiss-Prot:P9WL61"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45430.1"
/translation="MTDSEHVGKTCQIDVLIEEHDERTRAKARLSWAGRQMVGVGLAR
LDPADEPVAQIGDELAIARALSDLANQLFALTSSDIEASTHQPVTGLHH"
gene complement(2959335..2959820)
/locus_tag="Rv2633c"
CDS complement(2959335..2959820)
/codon_start=1
/transl_table=11
/locus_tag="Rv2633c"
/product="Hypothetical protein"
/note="Rv2633c, (MTCY441.03c), len: 161 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2633c"
/db_xref="EnsemblGenomes-Tr:CCP45431"
/db_xref="InterPro:IPR012312"
/db_xref="UniProtKB/Swiss-Prot:P9WL59"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45431.1"
/translation="MNAYDVLKRHHTVLKGLGRKVGEAPVNSEERHVLFDEMLIELDI
HFRIEDDLYYPALSAAGKPITGTHAEHRQVVDQLATLLRTPQRAPGYEEEWNVFRTVL
EAHADVEERDMIPAPTPVHITDAELEELGDKMAARIEQLRGSPLYTLRTKGKADLLKA
I"
gene complement(2960105..2962441)
/gene="PE_PGRS46"
/locus_tag="Rv2634c"
CDS complement(2960105..2962441)
/codon_start=1
/transl_table=11
/gene="PE_PGRS46"
/locus_tag="Rv2634c"
/product="PE-PGRS family protein PE_PGRS46"
/note="Rv2634c, (MTCY441.04c), len: 778 aa.
PE_PGRS46,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to many e.g.
O53553|YZ08_MYCTU|Rv3508|MTV023.15 from Mycobacterium
tuberculosis (1901 aa), FASTA scores: opt: 2553, E():
2.2e-93, (53.8% identity in 866 aa overlap). Equivalent to
AAK47026 from Mycobacterium tuberculosis strain CDC1551
(788 aa) but shorter 10 aa."
/db_xref="EnsemblGenomes-Gn:Rv2634c"
/db_xref="EnsemblGenomes-Tr:CCP45432"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIE7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45432.1"
/translation="MSFVIAVPEALTMAASDLANIGSTINAANAAAALPTTGVVAAAA
DEVSAAVAALFGSYAQSYQAFGAQLSAFHAQFVQSLTNGARSYVVAEATSAAPLQDLL
GVVNAPAQALLGRPLIGNGANGADGTGAPGGPGGLLLGNGGNGGSGAPGQPGGAGGDA
GLIGNGGTGGKGGDGLVGSGAAGGVGGRGGWLLGNGGTGGAGGAAGATLVGGTGGVGG
ATGLIGSGGFGGAGGAAAGVGTTGGVGGSGGVGGVFGNGGFGGAGGLGAAGGVGGAAS
YFGTGGGGGVGGDGAPGGDGGAGPLLIGNGGVGGLGGAGAAGGNGGAGGMLLGDGGAG
GQGGPAVAGVLGGMPGAGGNGGNANWFGSGGAGGQGGTGLAGTNGVNPGSIANPNTGA
NGTDNSGNGNQTGGNGGPGPAGGVGEAGGVGGQGGLGESLDGNDGTGGKGGAGGTAGT
DGGAGGAGGAGGIGETDGSAGGVATGGEGGDGATGGVDGGVGGAGGKGGQGHNTGVGD
AFGGDGGIGGDGNGALGAAGGNGGTGGAGGNGGRGGMLIGNGGAGGAGGTGGTGGGGA
AGFAGGVGGAGGEGLTDGAGTAEGGTGGLGGLGGVGGTGGMGGSGGVGGNGGAAGSLI
GLGGGGGAGGVGGTGGIGGIGGAGGNGGAGGAGTTTGGGATIGGGGGTGGVGGAGGTG
GTGGAGGTTGGSGGAGGLIGWAGAAGGTGAGGTGGQGGLGGQGGNGGNGGTGATGGQG
GDFALGGNGGAGGAGGSPGGSSGIQGNMGPPGTQGADG"
gene 2962470..2962712
/locus_tag="Rv2635"
CDS 2962470..2962712
/codon_start=1
/transl_table=11
/locus_tag="Rv2635"
/product="Hypothetical protein"
/note="Rv2635, (MTCY441.05), len: 80 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2635"
/db_xref="EnsemblGenomes-Tr:CCP45433"
/db_xref="UniProtKB/Swiss-Prot:P9WL57"
/protein_id="CCP45433.1"
/translation="MVAADHRALGSNKSYPASQTAEAIWPPARTLRYDRQSPWLATGF
DRRMSQTVTGVGVQNCAVSKRRCSAVDHSSRTPYRR"
gene 2962713..2963390
/locus_tag="Rv2636"
CDS 2962713..2963390
/codon_start=1
/transl_table=11
/locus_tag="Rv2636"
/product="Conserved hypothetical protein"
/note="Rv2636, (MTCY441.06), len: 225 aa. Conserved
hypothetical protein, showing some similarity with various
proteins: Q98FG2|MLL3789 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (239 aa), FASTA
scores: opt: 304, E(): 3.7e-13, (31.55% identity in 187 aa
overlap); CAC46568|SMC04451 putative chloramphenicol
phosphotransferase protein from Rhizobium meliloti
(Sinorhizobium meliloti) (220 aa), FASTA scores: opt:
175,E(): 0.00014, (28.0% identity in 225 aa overlap);
Q56148|CPT_STRVL chloramphenicol 3-O phosphotransferase
from Streptomyces violaceus (Streptomyces venezuelae) (178
aa), FASTA scores: opt: 131, E(): 0.1, (31.75% identity in
170 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop). Translational start site
uncertain,chosen by similarity."
/db_xref="EnsemblGenomes-Gn:Rv2636"
/db_xref="EnsemblGenomes-Tr:CCP45434"
/db_xref="GOA:P9WL55"
/db_xref="InterPro:IPR012853"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WL55"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45434.1"
/translation="MINPTRARRMRYRLAAMAGMPEGKLILLNGGSSAGKTSLALAFQ
DLAAECWMHIGIDLFWFALPPEQLDLARVRPEYYTWDSAVEADGLEWFTVHPGPILDL
AMHSRYRAIRAYLDNGMNVIADDVIWTREWLVDALRVFEGCRVWMVGVHVSDEEGARR
ELERGDRHPGWNRGSARAAHADAEYDFELDTTATPVHELARELHESYQACPYPMAFNR
LRKRFLS"
gene 2963586..2964242
/gene="dedA"
/locus_tag="Rv2637"
CDS 2963586..2964242
/codon_start=1
/transl_table=11
/gene="dedA"
/locus_tag="Rv2637"
/product="Possible transmembrane protein DedA"
/note="Rv2637, (MTCY441.07), len: 218 aa. Possible
dedA,transmembrane protein, equivalent to
Q49642|YQ37_MYCLE|ML0467|MLCL581.27|B1177_C2_172/B1177_C1_
140 hypothetical 23.1 KDA protein (potential integral
membrane protein, belongs to the DedA family) from
Mycobacterium leprae (214 aa), FASTA scores: opt: 1160,
E(): 4.4e-64,(82.75% identity in 209 aa overlap); and
O69601|Y364_MYCLE|ML0287|MLCB4.30 hypothetical protein
(potential integral membrane protein) (222 aa), FASTA
scores: opt: 292, E(): 6.6e-11, (32.25% identity in 189 aa
overlap). Also highly similar to other membrane proteins
e.g. CAC42863|SCBAC36F5.27c putative integral membrane
from Streptomyces coelicolor (211 aa), FASTA scores: opt:
837,E(): 2.6e-44, (59.2% identity in 201 aa overlap);
Q55705|Y232_SYNY3|SLR0232 potential integral membrane
protein from Synechocystis sp. strain PCC 6803 (218
aa),FASTA scores: opt: 415, E(): 1.9e-18, (37.85% identity
in 206 aa overlap); Q9RV63|DR1167 DEDA protein from
Deinococcus radiodurans (200 aa);
P09548|DEDA_ECOLI|B2317|Z3579|ECS3201 DEDA protein (DSG-1
protein) from Escherichia coli strains K12 and O157:H7
(219 aa), blast scores: 178, E(): 1.8e-13, Identities =
53/175 (30%); etc. Also similar to
O06314|Y364_MYCTU|Rv0364|MT0380|MTCY13E10.26 hypothetical
24.5 KDA protein (potential integral membrane protein)
from Mycobacterium tuberculosis (227 aa), FASTA scores:
opt: 293, E(): 5.8e-11, (35.85% identity in 184 aa
overlap). Belongs to the DedA family."
/db_xref="EnsemblGenomes-Gn:Rv2637"
/db_xref="EnsemblGenomes-Tr:CCP45435"
/db_xref="GOA:P9WP07"
/db_xref="InterPro:IPR032816"
/db_xref="InterPro:IPR032818"
/db_xref="UniProtKB/Swiss-Prot:P9WP07"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45435.1"
/translation="MDVEALLQSIPPLMVYLVVGAVVGIESLGIPLPGEIVLVSAAVL
SSHPELAVNPIGVGGAAVIGAVVGDSIGYSIGRRFGLPLFDRLGRRFPKHFGPGHVAL
AERLFNRWGVRAVFLGRFIALLRIFAGPLAGALKMPYPRFLAANVTGGICWAGGTTAL
VYFAGMAAQHWLERFSWIALVIAVIAGITAAILLRERTSRAIAELEAEHCRKAGTTAA
"
gene 2964405..2964851
/locus_tag="Rv2638"
CDS 2964405..2964851
/codon_start=1
/transl_table=11
/locus_tag="Rv2638"
/product="Conserved hypothetical protein"
/note="Rv2638, (MTCY441.08), len: 148 aa. Conserved
hypothetical protein, similar in part to
Q9WVX8|RSBV_STRCO|bldg|SCH5.12c anti-sigma B factor
antagonist from Streptomyces coelicolor (113 aa), FASTA
scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa
overlap); and showing weak similarity with various
proteins e.g. O69205 hypothetical 13.4 KDA protein from
Actinosynnema pretiosum (subsp. auranticum) (128 aa),
FASTA scores: opt: 157, E(): 0.0016, (29.8% identity in
114 aa overlap); Q9RJ93|SCF91.32 putative anti-sigma
factor antagonist from Streptomyces coelicolor (183 aa),
FASTA scores: opt: 148, E(): 0.0082, (30.85% identity in
107 aa overlap); etc. Also highly similar to hypothetical
proteins from Mycobacterium tuberculosis:
O07728|Rv1904|MTCY180.14c (143 aa), FASTA scores: opt:
456, E(): 3.9e-23, (52.8% identity in 125 aa overlap); and
Q11035|YD65_MYCTU|Rv1365c|MT1411|MTCY02B10.29c (128
aa),FASTA scores: opt: 435, E(): 8.6e-22, (53.6% identity
in 125 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2638"
/db_xref="EnsemblGenomes-Tr:CCP45436"
/db_xref="GOA:I6X4W0"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR003658"
/db_xref="InterPro:IPR036513"
/db_xref="UniProtKB/TrEMBL:I6X4W0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45436.1"
/translation="MGLITTEPRSSPHPLSPRLVHELGDPHSTLRATTDGSGAALLIH
AGGEIDGRNEHLWRQLVTEAAAGVTAPGPLIVDVTGLDFMGCCAFAALADEAQRCRCR
GIDLRLVSHQPIVARIAEAGGLSRVLPIYPTVDTALGKGTAGPARC"
gene complement(2965026..2965358)
/locus_tag="Rv2639c"
CDS complement(2965026..2965358)
/codon_start=1
/transl_table=11
/locus_tag="Rv2639c"
/product="Probable conserved integral membrane protein"
/note="Rv2639c, (MTCY441.09c), len: 110 aa. Probable
conserved integral membrane protein, highly similar to
many bacterial hypothetical or membrane proteins e.g.
Q9X889|YE14_STRCO|SCE15.14 potential integral membrane
protein from Streptomyces coelicolor (112 aa), FASTA
scores: opt: 597, E(): 3.1e-31, (73.15% identity in 108 aa
overlap); Q55939|Y793_SYNY3|SLL0793 potential integral
membrane protein from Synechocystis sp. strain PCC 6803
(108 aa), FASTA scores: opt: 341, E(): 4.9e-15, (51.4%
identity in 109 aa overlap); O31553|YFJF_BACSU potential
integral membrane protein from Bacillus subtilis (109
aa),FASTA scores: opt: 334, E(): 1.4e-14, (47.5% identity
in 109 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2639c"
/db_xref="EnsemblGenomes-Tr:CCP45437"
/db_xref="GOA:P9WFN9"
/db_xref="InterPro:IPR003844"
/db_xref="UniProtKB/Swiss-Prot:P9WFN9"
/protein_id="CCP45437.1"
/translation="MVVRSILLFVLAAVAEIGGAWLVWQGVREQRGWLWAGLGVIALG
VYGFFATLQPDAHFGRVLAAYGGVFVAGSLAWGMALDGFRPDRWDVIGALGCMAGVAV
IMYAPRGH"
gene complement(2965478..2965837)
/locus_tag="Rv2640c"
CDS complement(2965478..2965837)
/codon_start=1
/transl_table=11
/locus_tag="Rv2640c"
/product="Possible transcriptional regulatory protein
(probably ArsR-family)"
/note="Rv2640c, (MTCY441.10c), len: 119 aa. Possible
transcriptional regulator, arsR family, highly similar to
many e.g. Q9L1V5|SC4A9.07 putative ArsR-family
transcriptional regulator from Streptomyces coelicolor
(117 aa), FASTA scores: opt: 261, E(): 5.6e-10, (47.75%
identity in 103 aa overlap); Q9X8X8|SCH35.28c putative
transcriptional regulator from Streptomyces coelicolor
(122 aa), FASTA scores: opt: 252, E(): 2.2e-09, (37.05%
identity in 116 aa overlap); Q9L220|SC1A2.21 putative
ArsR-family transcriptional from Streptomyces coelicolor
(119 aa),FASTA scores: opt: 252, E(): 2.2e-09, (37.05%
identity in 116 aa overlap); P77295|YGAV_ECOLI|B2667
hypothetical transcriptional regulator from Escherichia
coli strain K12 (99 aa), FASTA scores: opt: 156, E():
0.0023, (34.1% identity in 88 aa overlap); etc. Also
similar to upstream ORF P71941|Rv2642|MTCY441.12 putative
transcriptional regulatory protein from Mycobacterium
tuberculosis (126 aa), FASTA scores: opt: 237, E(): 2e-08,
(38.55% identity in 109 aa overlap). Contains
helix-turn-helix motif at aa 59-80 (Score 1166, +3.16 SD).
Belongs to the ArsR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv2640c"
/db_xref="EnsemblGenomes-Tr:CCP45438"
/db_xref="GOA:I6Y1A7"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:I6Y1A7"
/protein_id="CCP45438.1"
/translation="MPKSLPVIDISAPVCCAPVAAGPMSDGDALAVALRLKALADPAR
VKIMSYLFSSPAGEQVSGQLAAALSLSDGTVSHHLAQLRKAGLVISDRRGMHVFHRVH
PEALQALCTVLNPNCCA"
gene 2965939..2966397
/gene="cadI"
/locus_tag="Rv2641"
CDS 2965939..2966397
/codon_start=1
/transl_table=11
/gene="cadI"
/locus_tag="Rv2641"
/product="Cadmium inducible protein CadI"
/note="Rv2641, (MTCY441.11), len: 152 aa. CadI, conserved
hypothetical protein. Gene induced by cadmium (see Hotter
et al., 2001), highly similar to hypothetical proteins
e.g. Q9L222|SC1A2.19c from Streptomyces coelicolor (152
aa),FASTA scores: opt: 509, E(): 2.3e-27, (55.05% identity
in 149 aa overlap); P45945|YQCK_BACSU from Bacillus
subtilis (146 aa), FASTA scores: opt: 295, E(): 5.4e-13,
(33.55% identity in 146 aa overlap); and Q98CF8|MLL5167
from Rhizobium loti (Mesorhizobium loti) (124 aa), FASTA
scores: opt: 110, E(): 1.3, (31.4% identity in 121 aa
overlap). Some similarity with
Q10548|Y887_MYCTU|Rv0887c|MT0910|MTCY31.15c from
Mycobacterium tuberculosis (152 aa), FASTA scores: opt:
108, E(): 2.1, (25.7% identity in 148 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2641"
/db_xref="EnsemblGenomes-Tr:CCP45439"
/db_xref="GOA:P9WIR5"
/db_xref="InterPro:IPR004360"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="UniProtKB/Swiss-Prot:P9WIR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45439.1"
/translation="MSRVQLALNVDDLEAAITFYSRLFNAEPAKRKPGYANFAIADPP
LKLVLLENPGTGGTLNHLGVEVGSSNTVHAEIARLTEAGLVTEKEIGTTCCFATQDKV
WVTGPGGERWEVYTVLADSETFGSGPRHNDTSDGEASMCCDGQVAVGASG"
gene 2966533..2966913
/locus_tag="Rv2642"
CDS 2966533..2966913
/codon_start=1
/transl_table=11
/locus_tag="Rv2642"
/product="Possible transcriptional regulatory protein
(probably ArsR-family)"
/note="Rv2642, (MTCY441.12), len: 126 aa. Possible
transcriptional regulator, arsR family, highly similar to
many e.g. Q9X8X8|SCH35.28c putative transcriptional
regulator from Streptomyces coelicolor (122 aa), FASTA
scores: opt: 390, E(): 3.7e-19, (56.55% identity in 122 aa
overlap); Q9L220|SC1A2.21 putative ArsR-family
transcriptional from Streptomyces coelicolor (119
aa),FASTA scores: opt: 378, E(): 2.3e-18, (59.8% identity
in 97 aa overlap); Q9L1V5|SC4A9.07 putative ArsR-family
transcriptional regulator from Streptomyces coelicolor
(117 aa), FASTA scores: opt: 359, E(): 4.1e-17, (56.9%
identity in 116 aa overlap); P52144|ARR2_ECOLI|ARSR from
Escherichia coli (117 aa), FASTA scores: opt: 202, E():
1e-06, (39.8% identity in 88 aa overlap); etc. Also
similar to downstream ORF P71939|Rv2640c|MTCY441.10c
putative transcriptional regulatory protein from
Mycobacterium tuberculosis (119 aa), FASTA scores: opt:
237, E(): 5e-09, (38.55% identity in 109 aa overlap); and
others from Mycobacterium tuberculosis e.g.
O05840|Rv2358|MTCY27.22c. Contains PS00846 Bacterial
regulatory proteins, arsR family signature. Contains
helix-turn-helix motif at aa 58-79 (Score 1112, +2.97 SD).
Belongs to the ArsR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv2642"
/db_xref="EnsemblGenomes-Tr:CCP45440"
/db_xref="GOA:P71941"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR018334"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P71941"
/inference="protein motif:PROSITE:PS00846"
/protein_id="CCP45440.1"
/translation="MSNLHPLPEVASCVVAPLVREPLNPPAAAEMAARFKALADPVRL
QLLSSVASRAGGEACVCDISAGVEVSQPTISHHLKVLRDAGLLTSRRRASWVYYAVVP
EALTVLSNLLSVHADAAPALGAPA"
gene 2966910..2968406
/gene="arsC"
/locus_tag="Rv2643"
CDS 2966910..2968406
/codon_start=1
/transl_table=11
/gene="arsC"
/locus_tag="Rv2643"
/product="Probable arsenic-transport integral membrane
protein ArsC"
/note="Rv2643, (MTCY441.13), len: 498 aa. Probable
arsC,arsenical resistance transport integral membrane
protein,highly similar or similar to others e.g.
Q9L1X4|SC3D9.05 possible arsenic resistance membrane
transport protein from Streptomyces coelicolor (368 aa),
FASTA scores: opt: 1729,E(): 2.2e-96, (74.3% identity in
358 aa overlap); Q9X8Y0|SCH35.26 putative heavy metal
resistance membrane protein from Streptomyces coelicolor
(369 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (73.8%
identity in 359 aa overlap);
Q06598|ACR3_YEAST|ACR3|YPR201W|P9677.2
arsenical-resistance protein from Saccharomyces cerevisiae
(Baker's yeast) (404 aa), FASTA scores: opt: 591, E():
4e-28, (36.6% identity in 380 aa overlap); etc. Belongs to
the ACR3 family."
/db_xref="EnsemblGenomes-Gn:Rv2643"
/db_xref="EnsemblGenomes-Tr:CCP45441"
/db_xref="GOA:I6X4W4"
/db_xref="InterPro:IPR002657"
/db_xref="InterPro:IPR004706"
/db_xref="InterPro:IPR023485"
/db_xref="InterPro:IPR036196"
/db_xref="InterPro:IPR038770"
/db_xref="UniProtKB/TrEMBL:I6X4W4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45441.1"
/translation="MTETVTRTAAPAVVGKLSTLDRFLPVWIGSAMAAGLLLGRWIPG
LHTALEGVQLDGISLPIALGLLIMMYPVLAKVRYDRLDTVTGDRKLLLSSLLLNWVLG
PALMFALAWLLLADLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIF
QVAMFAALGWFYLSVLPGWLGLEQTTIATSPWQIAKSVLIFLGIPLLAGYLSRRIGEK
TKGRNWYESRFLPKVGPWALYGLLFTIVILFALQGDQITGRPLDVARIALPLLAYFAI
MWVGGYLLGAALRLGYRRTTTLAFTAASNNFELAIAVAIATYGATSGQALAGVVGPLI
EVPVLVGLVYVSLALRNRLAGPNATHDADKPSVLFVCVHNAGRSQMAAGLLTHLAGDR
IEVRSAGTEPAGQVNPTAVAAMAEMGIDITANAPTLLTGGQVQSSDVVITMGCGDACP
YFPGVSYRNWKLPDPAGQPLDVVRMIRDDIADRVQALIAELLATAKTR"
gene complement(2968533..2968850)
/locus_tag="Rv2644c"
CDS complement(2968533..2968850)
/codon_start=1
/transl_table=11
/locus_tag="Rv2644c"
/product="Hypothetical protein"
/note="Rv2644c, (MTCY441.14c), len: 105 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2644c"
/db_xref="EnsemblGenomes-Tr:CCP45442"
/db_xref="GOA:P9WL53"
/db_xref="UniProtKB/Swiss-Prot:P9WL53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45442.1"
/translation="MSPRRTSGGVVPVDRYRIDEGLIVVLVFAGRDERRRTVCFADKF
GCVHIGNPDLYRPQTSLPQPLPISSHAISGSRFVETTNRADQQEPIGPNRAELFDQAL
HAG"
gene complement(2969497..2969568)
/gene="valT"
tRNA complement(2969497..2969568)
/gene="valT"
/product="tRNA-Val"
/anticodon=(pos:complement(2969534..2969536),aa:Val,
seq:cac)
/note="codon recognized: GUG; valT, tRNA-Val, anticodon
cac, length = 72"
gene 2969753..2969825
/gene="glyT"
tRNA 2969753..2969825
/gene="glyT"
/product="tRNA-Gly"
/anticodon=(pos:2969786..2969788,aa:Gly,seq:gcc)
/note="codon recognized: GGC; glyT, tRNA-Gly, anticodon
gcc, length = 73"
gene 2969855..2969925
/gene="cysU"
tRNA 2969855..2969925
/gene="cysU"
/product="tRNA-Cys"
/anticodon=(pos:2969887..2969889,aa:Cys,seq:gca)
/note="codon recognized: UGC; cysU, tRNA-Cys, anticodon
gca, length = 71"
gene 2969942..2970013
/gene="valU"
tRNA 2969942..2970013
/gene="valU"
/product="tRNA-Val"
/anticodon=(pos:2969974..2969976,aa:Val,seq:gac)
/note="codon recognized: GUC; valU, tRNA-Val, anticodon
gac, length = 72"
gene 2970123..2970554
/locus_tag="Rv2645"
CDS 2970123..2970554
/codon_start=1
/transl_table=11
/locus_tag="Rv2645"
/product="Hypothetical protein"
/note="Rv2645, (MTCY441.15), len: 143 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2645"
/db_xref="EnsemblGenomes-Tr:CCP45443"
/db_xref="UniProtKB/Swiss-Prot:P9WL51"
/protein_id="CCP45443.1"
/translation="MTTTPRQPLFCAHADTNGDPGRCACGQQLADVGPATPPPPWCEP
GTEPIWEQLTERYGGVTICQWTRYFPAGDPVAADVWIAADDRVVDGRVLRTQPAIHYT
EPPVLGIGPAAARRLAAELLNAADTLDDGRRQLDDLGEHRR"
gene 2970551..2971549
/locus_tag="Rv2646"
CDS 2970551..2971549
/codon_start=1
/transl_table=11
/locus_tag="Rv2646"
/product="Probable integrase"
/note="Rv2646, (MTCY441.16), len: 332 aa. Probable
integrase, similar to others e.g. P06723|VINT_BP186|int
integrase from Bacteriophage 186 (336 aa)s FASTA scores:
opt: 198, E(): 6.3e-05, (30.45% identity in 138 aa
overlap). Could be belong to the 'phage' integrase
family."
/db_xref="EnsemblGenomes-Gn:Rv2646"
/db_xref="EnsemblGenomes-Tr:CCP45444"
/db_xref="GOA:I6XEU5"
/db_xref="InterPro:IPR002104"
/db_xref="InterPro:IPR011010"
/db_xref="InterPro:IPR013762"
/db_xref="UniProtKB/TrEMBL:I6XEU5"
/protein_id="CCP45444.1"
/translation="MNTATRVRLARKRADRLNLKLIKNGHHFRLRDADEITLAVGHLG
VVEAFLAAAKSQNKPPGPPPSLHAPPSWRRDIDDYLLNLNAAGQRPATIRLRKTVLCA
AAHGLGRPPADVTAEHLLDWLGKQQHLSPEGRKTYRSTLRGFFVWAYEMDRVRDYVAD
SLPKVRCPKQPPRPAGDDVWQAALAKADRRIELMIRLAGEAGLRRAEAAQAHTGDLMD
GGLLLVHGKGGKRRIVPISDYLAALIRDTPHGYLFPNGTGGHLTAEHVGKLVSRALPG
DATMHTLRHRYATRAYRGSHNLRAVQQLLGHASIVTTERYTALCDDEVRAAAAAAW"
gene 2971659..2972027
/locus_tag="Rv2647"
CDS 2971659..2972027
/codon_start=1
/transl_table=11
/locus_tag="Rv2647"
/product="Hypothetical protein"
/note="Rv2647, (MTCY441.17), len: 122 aa (questionable
ORF). Hypothetical protein, probably corresponds to
conserved DNA sequence also found in MTCY336.29c and
Rv1574|MTCY336.30c|O06616 hypothetical 11.4 KDA protein
from Mycobacterium tuberculosis (103 aa), FASTA scores:
opt: 170, E(): 0.0002, (69.05% identity in 42 aa overlap).
Shows weak similarity with Q9EUM1|RESB resolvase protein
homolog from Corynebacterium glutamicum (Brevibacterium
flavum) (343 aa), FASTA scores: opt: 112, E(): 2.9,
(31.05% identity in 87 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2647"
/db_xref="EnsemblGenomes-Tr:CCP45445"
/db_xref="UniProtKB/TrEMBL:I6YDZ2"
/protein_id="CCP45445.1"
/translation="MHVCHTIADVVDRAKAERSENTLRKDFTPSELLAAGRRIAELER
PKAKQRQREGGDHGRQARYSGLGSMEPKPESERDAHKADTAISEALGISRGHYQRLKR
IDNATRSEAGYRDGLNGWSG"
repeat_region 2972106..2972108
/note="3 bp direct repeat: TCG at 5'-end of IS6110"
mobile_element 2972109..2973463
/mobile_element_type="insertion sequence:IS6110-10"
/note="IS6110-10, len: 1355 nt. Insertion sequence
IS6110."
repeat_region 2972109..2972136
/note="28 bp inverted repeat: TGAACCGCCCCGGCATGTCCGGAGACTC
at the left end of IS6110"
gene 2972160..2972486
/locus_tag="Rv2648"
CDS 2972160..2972486
/codon_start=1
/transl_table=11
/locus_tag="Rv2648"
/product="Probable transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv2648, (MTCY441.17A), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv2648 and
Rv2649,the sequence UUUUAAAG (directly upstream of Rv2649)
maybe responsible for such a frameshifting event (see
McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv2648"
/db_xref="EnsemblGenomes-Tr:CCP45446"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP45446.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <2972435..2973421
/locus_tag="Rv2649"
CDS <2972435..2973421
/codon_start=1
/transl_table=11
/locus_tag="Rv2649"
/product="Probable transposase for insertion sequence
element IS6110"
/note="Rv2649, (MTCY441.18), len: 328 aa. Probable
transposase for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv2648 and Rv2649, the
sequence UUUUAAAG (directly upstream of Rv2649) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv2649"
/db_xref="EnsemblGenomes-Tr:CCP45447"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP45447.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(2973436..2973463)
/note="28 bp inverted repeat,
TGAACCGCCCCGGTGAGTCCGGAGACTC,at the right end of IS6110."
repeat_region 2973464..2973466
/note="3 bp direct repeat: TCG at 3'-end of IS6110"
gene complement(2973795..2975234)
/locus_tag="Rv2650c"
CDS complement(2973795..2975234)
/codon_start=1
/transl_table=11
/locus_tag="Rv2650c"
/product="Possible PhiRv2 prophage protein"
/note="Rv2650c, (MTCY441.19), len: 479 aa. Possible phiRv2
prophage protein (capsid subunit) (see citation
below),highly similar to O06614|Rv1576c|MTCY336.28
probable phiRv1 phage protein from Mycobacterium
tuberculosis (473 aa),FASTA scores: opt: 2782, E():
2.8e-159, (89.1% identity in 468 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2650c"
/db_xref="EnsemblGenomes-Tr:CCP45448"
/db_xref="GOA:P71947"
/db_xref="InterPro:IPR024455"
/db_xref="UniProtKB/TrEMBL:P71947"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45448.1"
/translation="MTNEQHFADDGDIKQLSLDETRSAAKQLLDSVEGDLTGDVAQRF
QALTRHAEELRAEQRRRGREAEEALRRCRAGELRVVPGAPTGGDDGDAPPGNSLRDIA
FRTLDVCVRDGLMSSRAAEAAETLCRTGPPQSTSWAQRWLAATGNRDYLGAFVKRVSN
PVAGHTTWTDREAAAWREAAAVAAEQRAMGLVDTAGGFLIPAALDPAILLSGDGSTNP
IRQVARVVQTTSEVWRGVTSEGAEAHWYSEAQEVSDDSPTLAQPAVPSYRGSCWIPFS
LEIEGDAAGFVAEVGRVLADSVEQLQAAAFVSGSGNGEPTGFVSALTGTADYTVTGAG
TEAVVAADVYALQSALPPRFQSNSAFAANLSTINVLRQAETANGALKFPSLHASPPML
AGKHIWEVSNMDTVDAAVTATNYPLVLGDWKQFIITDRVGSTVELVPHVFGGNRRPTG
QRGFFCWFRVGSDVLVDNAFRVLKVQTTA"
gene complement(2975242..2975775)
/locus_tag="Rv2651c"
CDS complement(2975242..2975775)
/codon_start=1
/transl_table=11
/locus_tag="Rv2651c"
/product="Possible PhiRv2 prophage protease"
/note="Rv2651c, (MTCY441.20c), len: 177 aa. Possible
protease protein, phiRv2 phage protein (prohead protease)
(see citation below), showing some similarity with several
proteases e.g. Q9A4P4|CC2786 putative protease from
Caulobacter crescentus (138 aa), FASTA scores: opt:
206,E(): 2e-06, (36.35% identity in 132 aa overlap);
Q9RNH0 putative prohead protease from Rhodobacter
capsulatus (Rhodopseudomonas capsulata) (184 aa), FASTA
scores: opt: 196, E(): 1.1e-05, (35.05% identity in 137 aa
overlap); BAB35014|ECS1591 putative prohead protease from
Escherichia coli strain O157:H7 (185 aa), FASTA scores:
opt: 187, E(): 4.1e-05, (32.9% identity in 158 aa
overlap); etc. And highly similar to
O06613|Rv1577c|MTCY336.27 Probable phiRV1 phage protein
from Mycobacterium tuberculosis (170 aa),FASTA scores:
opt: 987, E(): 2.3e-56, (89.35% identity in 169 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2651c"
/db_xref="EnsemblGenomes-Tr:CCP45449"
/db_xref="GOA:I6XEX3"
/db_xref="InterPro:IPR006433"
/db_xref="UniProtKB/TrEMBL:I6XEX3"
/protein_id="CCP45449.1"
/translation="MSSILFRTAELRPGEGRTVYGVIVPYGEVTTVRDLDGEFREMFA
PGAFRRSIAERGHKVKLLVSHDARTRYPVGRAVELREEPHGLFGAFELANTPDGDEAL
ANVKAGVVDAFSVGFRPIRDRREGDVIVRVEAALLEVSLTGVPAYLGAQIAGVRAESL
AVVSRSLAEARLALMDW"
gene complement(2975928..2976554)
/locus_tag="Rv2652c"
CDS complement(2975928..2976554)
/codon_start=1
/transl_table=11
/locus_tag="Rv2652c"
/product="Probable PhiRv2 prophage protein"
/note="Rv2652c, (MTCY441.21c), len: 208 aa. Probable
phiRv2 phage protein (terminase) (see citation below),
showing some similarity with AAK79859|Q97HW1|CAC1896 phage
terminase-like protein (small subunit) from Clostridium
acetobutylicum (151 aa), FASTA scores: opt: 155, E():
0.012, (24.7% identity in 158 aa overlap); and Q9B019
hypothetical 17.8 KDA protein from Bacteriophage GMSE-1
(159 aa), FASTA scores: opt: 141, E(): 0.087, (27.65%
identity in 159 aa overlap). Also highly similar to
O06612|Rv1578c|MTCY336.26 Probable phiRV1 phage protein
from Mycobacterium tuberculosis (156 aa), FASTA scores:
opt: 448, E(): 1.2e-20, (48.1% identity in 156 aa
overlap). Equivalent to AAK47043 from Mycobacterium
tuberculosis strain CDC1551 but longer 45 aa."
/db_xref="EnsemblGenomes-Gn:Rv2652c"
/db_xref="EnsemblGenomes-Tr:CCP45450"
/db_xref="InterPro:IPR006448"
/db_xref="UniProtKB/TrEMBL:P71949"
/protein_id="CCP45450.1"
/translation="MPSPATARPDTATVGERVRAQVLWGVFWHHGIRDPKPGKRRVVL
KMGRRGPAPAPAQLKLLGGRSPGRDSGGRRVTPPAAFERVAPECPDWLPPGAKDMWGR
VVPELAALNLLKESDLGVLTSFCVAWDQLMQAVTAYREQGFIATNARSRRVTVHPAVA
AARAATRDVLVLARELGCTPSAEANLAAVLAAAGDPDDDEFNPFAPDR"
gene complement(2976586..2976909)
/locus_tag="Rv2653c"
CDS complement(2976586..2976909)
/codon_start=1
/transl_table=11
/locus_tag="Rv2653c"
/product="Possible PhiRv2 prophage protein"
/note="Rv2653c, (MTCY441.22c), len: 107 aa. Hypothetical
unknown protein, possibly phiRv2 phage protein (see
citation below)."
/db_xref="EnsemblGenomes-Gn:Rv2653c"
/db_xref="EnsemblGenomes-Tr:CCP45451"
/db_xref="GOA:P9WJ13"
/db_xref="UniProtKB/Swiss-Prot:P9WJ13"
/protein_id="CCP45451.1"
/translation="MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQR
QRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLDDEQRRLEAGMKLGWHPYHFPDE
PDSKQ"
gene complement(2976989..2977234)
/locus_tag="Rv2654c"
CDS complement(2976989..2977234)
/codon_start=1
/transl_table=11
/locus_tag="Rv2654c"
/product="Possible PhiRv2 prophage protein"
/note="Rv2654c, (MTCY441.23c), len: 81 aa. Hypothetical
ala-rich protein, possibly phiRv2 phage protein (see
citation below), similar to C-terminus of Q9HNI3|VNG2091H
hypothetical protein from Halobacterium sp. strain NRC-1
(212 aa), FASTA scores: opt: 122, E(): 0.46, (43.05%
identity in 79 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2654c"
/db_xref="EnsemblGenomes-Tr:CCP45452"
/db_xref="GOA:P9WJ11"
/db_xref="UniProtKB/Swiss-Prot:P9WJ11"
/protein_id="CCP45452.1"
/translation="MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAV
ELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDPP"
gene complement(2977231..2978658)
/locus_tag="Rv2655c"
CDS complement(2977231..2978658)
/codon_start=1
/transl_table=11
/locus_tag="Rv2655c"
/product="Possible PhiRv2 prophage protein"
/note="Rv2655c, (MTCY441.24c), len: 475 aa. Hypothetical
protein, possibly phiRv2 phage protein (putative
primase-like protein) (see citation below). C-terminus
similar to P22875|YXIS_SACER hypothetical 28.9 KDA protein
(probably does not play a direct role in plasmid
integration or excision) from Saccharopolyspora erythraea
(Streptomyces erythraeus) plasmid pSE211 (263 aa), FASTA
scores: opt: 389, E(): 2.7e-15, (33.45% identity in 269 aa
overlap). Weak similarity in N-terminus to
O06608|MTCY336.22|Rv1582c Probable phiRV1 phage protein
from Mycobacterium tuberculosis (471 aa), FASTA scores:
opt: 133, E(): 2.5, (36.0% identity in 75 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2655c"
/db_xref="EnsemblGenomes-Tr:CCP45453"
/db_xref="InterPro:IPR022081"
/db_xref="UniProtKB/TrEMBL:I6Y1F0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45453.1"
/translation="MADIPYGRDYPDPIWCDEDGQPMPPVGAELLDDIRAFLRRFVVY
PSDHELIAHTLWIAHCWFMEAWDSTPRIAFLSPEPGSGKSRALEVTEPLVPRPVHAIN
CTPAYLFRRVADPVGRPTVLYDECDTLFGPKAKEHEEIRGVINAGHRKGAVAGRCVIR
GKIVETEELPAYCAVALAGLDDLPDTIMSRSIVVRMRRRAPTEPVEPWRPRVNGPEAE
KLHDRLANWAAAINPLESGWPAMPDGVTDRRADVWESLVAVADTAGGHWPKTARATAE
TDATANRGAKPSIGVLLLRDIRRVFSDRDRMRTSDILTGLNRMEEGPWGSIRRGDPLD
ARGLATRLGRYGIGPKFQHSGGEPPYKGYSRTQFEDAWSRYLSADDETPEERDLSVSA
VSAVSPPVGDPGDATGATDATDLPEAGDLPYEPPAPNGHPNGDAPLCSGPGCPNKLLS
TEAKAAGKCRPCRGRAAASARDGAR"
gene complement(2978660..2979052)
/locus_tag="Rv2656c"
CDS complement(2978660..2979052)
/codon_start=1
/transl_table=11
/locus_tag="Rv2656c"
/product="Possible PhiRv2 prophage protein"
/note="Rv2656c, (MTCY441.25c), len: 130 aa. Probable
phiRv2 phage protein (see Hatfull 2000), highly similar to
O06607|YF83_MYCTU|Rv1583c|MT3573.2|MTCY336.21 Probable
phiRV1 phage protein from Mycobacterium tuberculosis (132
aa), FASTA scores: opt: 734, E(): 2.5e-39, (81.5% identity
in 131 aa overlap); and some similarity with
Q982T4|MLL8506 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (204 aa), FASTA scores: opt: 104,
E(): 9.7, (31.85% identity in 113 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2656c"
/db_xref="EnsemblGenomes-Tr:CCP45454"
/db_xref="InterPro:IPR024384"
/db_xref="UniProtKB/Swiss-Prot:P9WL49"
/protein_id="CCP45454.1"
/translation="MTAVGGSPPTRRCPATEDRAPATVATPSSTDPTASRAVSWWSVH
EYVAPTLAAAVEWPMAGTPAWCDLDDTDPVKWAAICDAARHWALRVETCQAASAEASR
DVSAAADWPAVSREIQRRRDAYIRRVVV"
gene complement(2979049..2979309)
/locus_tag="Rv2657c"
CDS complement(2979049..2979309)
/codon_start=1
/transl_table=11
/locus_tag="Rv2657c"
/product="Probable PhiRv2 prophage protein"
/note="Rv2657c, (MTCY441.26c), len: 86 aa. Probable phiRv2
phage protein (excisionase) (see citation below), similar
to O22001|VG36_BPMD2|36|G2 gene 36 protein (GP36) from
Mycobacteriophage D29 (56 aa), FASTA scores: opt: 171,
E(): 9.6e-06, (48.0% identity in 50 aa overlap); and
Q05246|VG36_BPML5|36 gene 36 protein (GP36) from
Mycobacteriophage L5 (56 aa), FASTA scores: opt: 169, E():
1.3e-05, (50% identity in 50 aa overlap). Similarity
suggests alternative start at 21737. Contains possible
helix-turn-helix motif from aa 33 to 54 (Score 1655, +4.82
SD)."
/db_xref="EnsemblGenomes-Gn:Rv2657c"
/db_xref="EnsemblGenomes-Tr:CCP45455"
/db_xref="GOA:I6YE30"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR010093"
/db_xref="InterPro:IPR041657"
/db_xref="UniProtKB/TrEMBL:I6YE30"
/protein_id="CCP45455.1"
/translation="MCAFPSPSLGWTVSHETERPGMADAPPLSRRYITISEAAEYLAV
TDRTVRQMIADGRLRGYRSGTRLVRLRRDEVDGAMHPFGGAA"
gene complement(2979326..2979688)
/locus_tag="Rv2658c"
CDS complement(2979326..2979688)
/codon_start=1
/transl_table=11
/locus_tag="Rv2658c"
/product="Possible prophage protein"
/note="Rv2658c, (MTCY441.27c), len: 120 aa. Hypothetical
unknown protein, probably phage protein."
/db_xref="EnsemblGenomes-Gn:Rv2658c"
/db_xref="EnsemblGenomes-Tr:CCP45456"
/db_xref="UniProtKB/Swiss-Prot:P9WL47"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45456.1"
/translation="MADAVKYVVMCNCDDEPGALIIAWIDDERPAGGHIQMRSNTRFT
ETQWGRHIEWKLECRACRKYAPISEMTAAAILDGFGAKLHELRTSTIPDADDPSIAEA
RHVIPFSALCLRLSQLGG"
gene complement(2979691..2980818)
/locus_tag="Rv2659c"
CDS complement(2979691..2980818)
/codon_start=1
/transl_table=11
/locus_tag="Rv2659c"
/product="Probable PhiRv2 prophage integrase"
/note="Rv2659c, (MTCY441.28c), len: 375 aa. Probable
integrase, phiRv2 phage protein: putative member of the
phage integrase family of tyrosine recombinases (see
Hatfull 2000), highly similar to others e.g.
P22884|VINT_BPML5|33|int from Mycobacteriophage L5 (371
aa), FASTA scores: opt: 836, E(): 1.2e-44, (39.0% identity
in 372 aa overlap); Q38361|VINT_BPMD2|33|int from
Mycobacteriophage D29 (333 aa), FASTA scores: opt:
786,E(): 1.4e-41, (40.55% identity in 338 aa overlap);
etc. Seems belongs to the 'phage' integrase family."
/db_xref="EnsemblGenomes-Gn:Rv2659c"
/db_xref="EnsemblGenomes-Tr:CCP45457"
/db_xref="GOA:P9WMB3"
/db_xref="InterPro:IPR002104"
/db_xref="InterPro:IPR004107"
/db_xref="InterPro:IPR010998"
/db_xref="InterPro:IPR011010"
/db_xref="InterPro:IPR013762"
/db_xref="UniProtKB/Swiss-Prot:P9WMB3"
/protein_id="CCP45457.1"
/translation="MTQTGKRQRRKFGRIRQFNSGRWQASYTGPDGRVYIAPKTFNAK
IDAEAWLTDRRREIDRQLWSPASGQEDRPGAPFGEYAEGWLKQRGIKDRTRAHYRKLL
DNHILATFADTDLRDITPAAVRRWYATTAVGTPTMRAHSYSLLRAIMQTALADDLIDS
NPCRISGASTARRVHKIRPATLDELETITKAMPDPYQAFVLMAAWLAMRYGELTELRR
KDIDLHGEVARVRRAVVRVGEGFKVTTPKSDAGVRDISIPPHLIPAIEDHLHKHVNPG
RESLLFPSVNDPNRHLAPSALYRMFYKARKAAGRPDLRVHDLRHSGAVLAASTGATLA
ELMQRLGHSTAGAALRYQHAAKGRDREIAALLSKLAENQEM"
gene complement(2980963..2981190)
/locus_tag="Rv2660c"
CDS complement(2980963..2981190)
/codon_start=1
/transl_table=11
/locus_tag="Rv2660c"
/product="Hypothetical protein"
/note="Rv2660c, (MTCY441.29c), len: 75 aa (questionable
orf). Hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2660c"
/db_xref="EnsemblGenomes-Tr:CCP45458"
/db_xref="UniProtKB/TrEMBL:I6Y1F5"
/protein_id="CCP45458.1"
/translation="MIAGVDQALAATGQASQRAAGASGGVTVGVGVGTEQRNLSVVAP
SQFTFSSRSPDFVDETAGQSWCAILGLNQFH"
gene complement(2981187..2981576)
/locus_tag="Rv2661c"
CDS complement(2981187..2981576)
/codon_start=1
/transl_table=11
/locus_tag="Rv2661c"
/product="Hypothetical protein"
/note="Rv2661c, (MTCY441.30c), len: 129 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2661c"
/db_xref="EnsemblGenomes-Tr:CCP45459"
/db_xref="UniProtKB/TrEMBL:P71958"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45459.1"
/translation="MRARSDAGGQSVKSRTSNRSRSSRRSRVRSSISALVDNPQARPR
ELPVLCGWPVVRVEPVCEFVPEPVCGQAEVLGEPAAAHRVTSARRSPSTTVCSRSQKA
SAVVISSVSSVARVRRASVSSVDATTA"
gene 2981482..2981754
/locus_tag="Rv2662"
CDS 2981482..2981754
/codon_start=1
/transl_table=11
/locus_tag="Rv2662"
/product="Hypothetical protein"
/note="Rv2662, (MTCY441.31), len: 90 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2662"
/db_xref="EnsemblGenomes-Tr:CCP45460"
/db_xref="UniProtKB/TrEMBL:P71959"
/protein_id="CCP45460.1"
/translation="MDDLTRLRRELLDRFDVRDFTDWPPASLRALIATYDPWIDMTAS
PPQPVSPGGPRLRLVRLTTNPSARAAPIGNGGDSSVCAGEKQCRPP"
gene 2981853..2982086
/locus_tag="Rv2663"
CDS 2981853..2982086
/codon_start=1
/transl_table=11
/locus_tag="Rv2663"
/product="Hypothetical protein"
/note="Rv2663, (MTCY441.32), len: 77 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2663"
/db_xref="EnsemblGenomes-Tr:CCP45461"
/db_xref="UniProtKB/TrEMBL:I6X520"
/protein_id="CCP45461.1"
/translation="MEVRASARKHGINDDAMLHAYRNALRYVELEYHGEVQLLVIGPD
QTGRLLELVIPADEPPRIIHANVLRPKFYDYLR"
gene 2982097..2982351
/locus_tag="Rv2664"
CDS 2982097..2982351
/codon_start=1
/transl_table=11
/locus_tag="Rv2664"
/product="Hypothetical protein"
/note="Rv2664, (MTCY441.33), len: 84 aa. Hypothetical
protein. Some weak similarity to nearby
P71964|Rv2667|clpX'|MT2741|MTCY441.36 possible
ATP-dependent protease ATP-binding subunit from
Mycobacterium tuberculosis (252 aa), FASTA scores: opt:
134, E(): 0.027, (31.15% identity in 77 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2664"
/db_xref="EnsemblGenomes-Tr:CCP45462"
/db_xref="UniProtKB/TrEMBL:I6Y9Z5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45462.1"
/translation="MKHKTDIDEWLDTIEPNPADAHDASHLRRIIAAKEAVQTAESEL
RAAVNAARAAGDTWAAIGVALGITRQAAFQRFGPHSTASP"
gene 2982699..2982980
/locus_tag="Rv2665"
CDS 2982699..2982980
/codon_start=1
/transl_table=11
/locus_tag="Rv2665"
/product="Hypothetical arginine rich protein"
/note="Rv2665, (MTCY441.34), len: 93 aa. Hypothetical
arg-rich protein, showing some similarity to N-terminus of
P71640|Rv2811|MTCY16B7.32c hypothetical 21.1 KDA protein
from Mycobacterium tuberculosis (202 aa), FASTA scores:
opt: 157, E(): 0.0011, (37.5% identity in 72 aa overlap);
and also to part of O35132|CP2B_RAT|CYP27B1|CYP27B
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
precursor from Rattus norvegicus (Rat) (501 aa), FASTA
scores: opt: 106, E(): 5.4, (34.5% identity in 87 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2665"
/db_xref="EnsemblGenomes-Tr:CCP45463"
/db_xref="UniProtKB/TrEMBL:I6Y1F9"
/protein_id="CCP45463.1"
/translation="MIVVRTAEAAEQALTEGQLVCPRRGCGDTLRRWRYGRRRHVRSL
GSQVIDVRPQRVRCRRCESTHVLLPAALQPRLGRGGGGQLRPGVWCTGR"
mobile_element 2982946..2983854
/mobile_element_type="insertion sequence:IS1081'-4"
/note="IS1081'-4, len: 909 nt. Defective Insertion
sequence IS1081 element; truncated at 3'-end."
repeat_region 2983019..2983033
/note="15 bp Inverted repeat at the left end of
IS1081:TCGCGTGATCCTTCG, right end copy is missing"
gene 2983071..2983874
/locus_tag="Rv2666"
CDS 2983071..2983874
/codon_start=1
/transl_table=11
/locus_tag="Rv2666"
/product="Probable transposase for insertion sequence
element IS1081 (fragment)"
/note="Rv2666, (MTCY441.35), len: 267 aa. Probable
transposase (fragment), identical in region of overlap to
P35882|TRA1_MYCBO|TRA1_MYCTU transposase for insertion
sequence element IS1081 from Mycobacterium tuberculosis or
bovis (415 aa). Last 4 codons not part of gene. Contains
PS01007 Transposases, Mutator family, signature."
/db_xref="EnsemblGenomes-Gn:Rv2666"
/db_xref="EnsemblGenomes-Tr:CCP45464"
/db_xref="GOA:P71963"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/TrEMBL:P71963"
/inference="protein motif:PROSITE:PS01007"
/protein_id="CCP45464.1"
/translation="MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADAL
CGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERA
LTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGP
YTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRD
LVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANHGRHNA"
gene 2983896..2984654
/gene="clpC2"
/gene_synonym="clpX'"
/locus_tag="Rv2667"
CDS 2983896..2984654
/codon_start=1
/transl_table=11
/gene="clpC2"
/gene_synonym="clpX'"
/locus_tag="Rv2667"
/product="Possible ATP-dependent protease ATP-binding
subunit ClpC2"
/note="Rv2667, (MTCY441.36), len: 252 aa. Possible
clpC2,ATP-dependent protease atp-binding subunit, highly
similar to Q9X8L2|SCE9.40 hypothetical 27.3 KDA protein
from Streptomyces coelicolor (258 aa), FASTA scores: opt:
877,E(): 2.2e-46, (57.25% identity in 255 aa overlap). The
second half of the protein is highly similar to N-terminal
of several CLP-family proteins e.g.
P24428|CLPC_MYCLE|ML0235 probable ATP-dependent CLP
protease ATP-binding subunit from Mycobacterium leprae
(848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6%
identity in 158 aa overlap);
O06286|CLPC_MYCTU|Rv3596c|MT3703|MTCY07H7B.26 probable
ATP-dependent CLP protease ATP-binding subunit from
Mycobacterium tuberculosis (848 aa), FASTA scores: opt:
307, E(): 3.2e-11, (38.6% identity in 158 aa overlap);
Q9S6T8|SCE94.24c putative CLP-family ATP-binding protease
from Streptomyces coelicolor (841 aa), FASTA scores: opt:
303, E(): 5.6e-11, (38.8% identity in 152 aa overlap);
etc. Some weak similarity to nearby
P71961|MTCY441.33|Rv2664 hypothetical protein from
Mycobacterium tuberculosis (83 aa). Contain Pfam match to
entry PF02861 Clp amino terminal domain. Belongs to the
CLPA/CLPB family. CLPC subfamily. Note that previously
known as clpX'"
/db_xref="EnsemblGenomes-Gn:Rv2667"
/db_xref="EnsemblGenomes-Tr:CCP45465"
/db_xref="GOA:P9WPC7"
/db_xref="InterPro:IPR004176"
/db_xref="InterPro:IPR036628"
/db_xref="UniProtKB/Swiss-Prot:P9WPC7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45465.1"
/translation="MPEPTPTAYPVRLDELINAIKRVHSDVLDQLSDAVLAAEHLGEI
ADHLIGHFVDQARRSGASWSDIGKSMGVTKQAAQKRFVPRAEATTLDSNQGFRRFTPR
ARNAVVAAQNAAHGAASSEITPDHLLLGVLTDPAALATALLQQQEIDIATLRTAVTLP
PAVTEPPQPIPFSGPARKVLELTFREALRLGHNYIGTEHLLLALLELEDGDGPLHRSG
VDKSRAEADLITTLASLTGANAAGATDAGATDAG"
gene 2984733..2985254
/locus_tag="Rv2668"
CDS 2984733..2985254
/codon_start=1
/transl_table=11
/locus_tag="Rv2668"
/product="Possible exported alanine and valine rich
protein"
/note="Rv2668, (MTCY441.37), len: 173 aa. Hypothetical
ala-, val-rich protein, possibly exported. Equivalent to
AAK47057 from Mycobacterium tuberculosis strain CDC1551
(208 aa) but N-terminal part shorter 35 aa and with few
differences. Has potential signal peptide sequence.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv2668"
/db_xref="EnsemblGenomes-Tr:CCP45466"
/db_xref="UniProtKB/TrEMBL:P71965"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45466.1"
/translation="MRHWLIVLATLLVAAAGVAAANDVPRAWAGDAPIGHIGDTLRVD
TGTYVADVTVSSVVPVDPPPGFGYTRSGVPVKSFPDSSVTRADVTVRAVRVPNSFILA
TNFSFTGVTPFADAYKPRPCDASDWLDAALGNAPQGSIVRGGVYWDAYRDPVSVVVLL
DEKTGQHLAQWNL"
gene 2985283..2985753
/locus_tag="Rv2669"
CDS 2985283..2985753
/codon_start=1
/transl_table=11
/locus_tag="Rv2669"
/product="GCN5-related N-acetyltransferase"
/note="Rv2669, (MTCY441.38), len: 156 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain. See Vetting et al. 2005.
Similarity to several proteins e.g. Q9A6M0|CC2073
acetyltransferase (GNAT family) from Caulobacter
crescentus (178 aa), FASTA scores: opt: 242, E(): 1.2e-09,
(30.9% identity in 165 aa overlap); Q99RQ8|SA2159
hypothetical protein similar to transcription repressor of
sporulation,septation and degradation paiA from
Staphylococcus aureus subsp. aureus N315 (171 aa), FASTA
scores: opt: 214, E(): 9.8e-08, (27.5% identity in 160 aa
overlap); BAB58531|SAV2369 hypothetical 20.1 KDA protein
from Staphylococcus aureus subsp. aureus Mu50 (171 aa),
FASTA scores: opt: 214, E(): 9.8e-08, (27.5% identity in
160 aa overlap); P21340|PAIA_BACSU|O32112 protease
synthase and sporulation from Bacillus subtilis (171 aa),
FASTA scores: opt: 209, E(): 2.1e-07, (22.85% identity in
162 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2669"
/db_xref="EnsemblGenomes-Tr:CCP45467"
/db_xref="GOA:P9WQG5"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/Swiss-Prot:P9WQG5"
/protein_id="CCP45467.1"
/translation="MTDADELAAVAARTFPLACPPAVAPEHIASFVDANLSSARFAEY
LTDPRRAILTARHDGRIVGYAMLIRGDDRDVELSKLYLLPGYHGTGAAAALMHKVLAT
AADWGALRVWLGVNQKNQRAQRFYAKTGFKINGTRTFRLGAHHENDYVMVRELV"
gene complement(2985731..2986840)
/locus_tag="Rv2670c"
CDS complement(2985731..2986840)
/codon_start=1
/transl_table=11
/locus_tag="Rv2670c"
/product="Conserved hypothetical protein"
/note="Rv2670c, (MTCY441.39c), len: 369 aa. Conserved
hypothetical protein, equivalent, but longer 164 aa, to
O05683|MLC1351.22c hypothetical 17.3 KDA protein from
Mycobacterium leprae (160 aa), FASTA scores: opt: 847,
E(): 1.2e-45, (82.4% identity in 159 aa overlap). And
highly similar to Q9X824|SC9B1.04c putative
ATP/GTP-binding integral membrane protein from
Streptomyces coelicolor (350 aa), FASTA scores: opt: 1169,
E(): 2e-65, (56.85% identity in 343 aa overlap); and
Q9RWB0|DR0759 conserved hypothetical protein from
Deinococcus radiodurans (351 aa),FASTA scores: opt: 859,
E(): 4e-46, (45.9% identity in 331 aa overlap). Also some
similarity with other proteins e.g.
P46442|YHCM_ECOLI|AAG58360|BAB37528 hypothetical protein
from Escherichia coli strains K12 and O157:H7 (375
aa),FASTA scores: opt: 237, E(): 2.1e-07, (28.0% identity
in 325 aa overlap); Q9JRK2|NMA1520|NMB1306 putative
nucleotide-binding protein from Neisseria meningitidis
(serogroup a and B) (383 aa), FASTA scores: opt: 221, E():
2.1e-06, (27.8% identity in 356 aa overlap); Q9HVX7|PA4438
hypothetical protein from Pseudomonas aeruginosa (364
aa),FASTA scores: opt: 211, E(): 8.5e-06, (28.9% identity
in 353 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2670c"
/db_xref="EnsemblGenomes-Tr:CCP45468"
/db_xref="GOA:I6Y1G3"
/db_xref="InterPro:IPR004435"
/db_xref="InterPro:IPR005654"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:I6Y1G3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45468.1"
/translation="MTLIAARRYSATMHGSASEACGSVDHLVDRHPTVSPVRLIAQLR
PPPTFAEVSFATYRPDPVEPTQAAAVVACQDFCRQAVERRAGRKKWFGKRDVLPGVGL
YLDGGFGVGKTHLLASAYYQLPGTGPDAPTCPKAFATFGELTQLAGVFGFADCIDLLA
NYTALCIDEFELDDPGNTTLISRLLSALVERGVSVAATSNTLPEQLGEGRFAAQDFLR
EINTLASIFTTVRIEGPDYRHRDLPPAPAPLSDEEVAARAARVEGATLDDFDALCAHL
ATMHPSRYLTLIEGVTAVFLTGVHGIDDQNVALRLVALVDRLYDAGIPVVASGAKLDT
IFSEEMLAGGYRKKYLRATSRLLALTAGVIQAREP"
gene 2986839..2987615
/gene="ribD"
/gene_synonym="ribG"
/locus_tag="Rv2671"
CDS 2986839..2987615
/codon_start=1
/transl_table=11
/gene="ribD"
/gene_synonym="ribG"
/locus_tag="Rv2671"
/product="Possible bifunctional enzyme riboflavin
biosynthesis protein RibD:
diaminohydroxyphosphoribosylaminopyrimidine deaminase
(riboflavin-specific deaminase) +
5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP
reductase)"
/note="Rv2671, (MTCY441.40), len: 258 aa. Possible ribD
(alternate gene name: ribG), bifunctional riboflavin
biosynthesis protein incuding
diaminohydroxyphosphoribosylaminopyrimidine deaminase and
5-amino-6-(5-phosphoribosylamino) uracil reductase, highly
similar to O05684|MLC1351.23|ML1340 possible reductase
from Mycobacterium leprae (268 aa), FASTA scores: opt:
1211,E(): 3e-68, (72.9% identity in 251 aa overlap). Also
weakly similar to others e.g. Q9HWX2|RIBD|PA4056
riboflavin-specific deaminase/reductase from Pseudomonas
aeruginosa (373 aa), FASTA scores: opt: 211, E():
6.3e-06,(30.1% identity in 216 aa overlap);
Q9HQA1|RIBG|VNG1256G riboflavin-specific deaminase from
Halobacterium sp. strain NRC-1 (220 aa), FASTA scores:
opt: 202, E(): 1.5e-05,(27.0% identity in 174 aa overlap);
O28272|RIB7_ARCFU|AF2007 putative
5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP
reductase) from Archaeoglobus fulgidus (219 aa), FASTA
scores: opt: 209, E(): 5.4e-06, (24.15% identity in 211 aa
overlap); P25539|RIBD_ECOLI|RIBG|B0414 from Escherichia
coli strain K12 (367 aa), FASTA scores: opt: 185, E():
0.00026, (26.7% identity in 221 aa overlap); etc. But also
similar to several hydrolases e.g. Q9X825|SC9B1.05
putative hydrolase from Streptomyces coelicolor (265 aa),
FASTA scores: opt: 536, E(): 2.9e-26, (44.25% identity in
235 aa overlap); Q9RKM1|SCD17.10 putative bifunctional
enzyme deaminase/reductase from Streptomyces coelicolor
(376 aa),FASTA scores: opt: 228, E(): 5.6e-07, (33.5%
identity in 188 aa overlap); etc. Equivalent to AAK47060
from Mycobacterium tuberculosis strain CDC1551 (239 aa)
but longer 19 aa. Supposed belong to the cytidine and
deoxycytidylate deaminases family in the N-terminal
section; and to the HTP reductase family in the C-terminal
section."
/db_xref="EnsemblGenomes-Gn:Rv2671"
/db_xref="EnsemblGenomes-Tr:CCP45469"
/db_xref="GOA:P71968"
/db_xref="InterPro:IPR002734"
/db_xref="InterPro:IPR024072"
/db_xref="PDB:4XRB"
/db_xref="PDB:4XT4"
/db_xref="PDB:4XT5"
/db_xref="PDB:4XT6"
/db_xref="PDB:4XT7"
/db_xref="PDB:4XT8"
/db_xref="PDB:6DE5"
/db_xref="UniProtKB/TrEMBL:P71968"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45469.1"
/translation="MPDSGQLGAADTPLRLLSSVHYLTDGELPQLYDYPDDGTWLRAN
FISSLDGGATVDGTSGAMAGPGDRFVFNLLRELADVIVVGVGTVRIEGYSGVRMGVVQ
RQHRQARGQSEVPQLAIVTRSGRLDRDMAVFTRTEMAPLVLTTTAVADDTRQRLAGLA
EVIACSGDDPGTVDEAVLVSQLAARGLRRILTEGGPTLLGTFVERDVLDELCLTIAPY
VVGGLARRIVTGPGQVLTRMRCAHVLTDDSGYLYTRYVKT"
gene 2987682..2989268
/locus_tag="Rv2672"
CDS 2987682..2989268
/codon_start=1
/transl_table=11
/locus_tag="Rv2672"
/product="Possible secreted protease"
/note="Rv2672, (MTCY441.41), len: 528 aa. Possible
secreted protease, equivalent to O05685|MLC1351.24|ML1339
putative secreted protease from Mycobacterium leprae (525
aa), FASTA scores: opt: 2722, E(): 9.4e-140, (74.45%
identity in 528 aa overlap). Also similar to several
exported proteinases from Streptomyces and Mycobacteria
e.g. Q54399|SLPE proteinase from Streptomyces lividans
(513 aa), FASTA scores: opt: 429, E(): 6.8e-16, (26.2%
identity in 538 aa overlap); Q9FCK9|2SC3B6.03c peptidase
from Streptomyces coelicolor (513 aa), FASTA scores: opt:
421, E(): 1.8e-15,(26.45% identity in 541 aa overlap);
Q10508|YM23_MYCTU from Mycobacterium tuberculosis (520
aa), FASTA scores: opt: 349, E(): 1.4e-11, (26.6% identity
in 523 aa overlap); etc. Equivalent to AAK47061 from
Mycobacterium tuberculosis strain CDC1551 (518 aa) but
longer 10 aa. Conserved in M. tuberculosis, M. leprae, M.
bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007). Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2672"
/db_xref="EnsemblGenomes-Tr:CCP45470"
/db_xref="GOA:P71969"
/db_xref="InterPro:IPR013595"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P71969"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45470.1"
/translation="MATVVGMSRPMTSTAMLVALTCSATVLAACVPAFGADPRFATYS
GAGPQGAATTTPPPAGPPPLAAPKNDLSWHDCTSRVYSNAGIPAAPGVKLECASYDTD
LDPLVGGSTAVSIGVVRARSNQTPSDAGPLVFTTGSDLPSSTQLPVWLAHAGIDVLRS
HPIVAVDRRGMGMSSPIDCRDHFDRDEMRDQAQFQAGDDPVANLSDISNTATTDCTDA
IAPGESAYDNTHAASDIERLRKLWDVPALAFVGIGNGTQVALAYAASRPDNVARLILD
SPIALGVSAEAAAEQQVQGQQAALDAFAAQCVAVNCALGSHPKGAVSALLSAARSGDG
PGGASVAAVANAVATALGFPDSGRVDSTTKLADALAAARSGDMNLLSALINRADTTRD
TDGQFISSCSDAVNRPTPDRVRELVVAWGKLYPQFGAVAALNLVKCVHWPSSSPPQPP
KDLKVDVLLLGVQNDPIVGNEGVAATAATAINANAASKRVMWQGIGHGASIYSSCAVP
PLVAYLDTGKLPDTDTYCPA"
gene 2989291..2990592
/gene="aftC"
/locus_tag="Rv2673"
CDS 2989291..2990592
/codon_start=1
/transl_table=11
/gene="aftC"
/locus_tag="Rv2673"
/product="Possible arabinofuranosyltransferase AftC"
/note="Rv2673, (MTCY441.42), len: 433 aa. Possible
aftC,arabinofuranosyltransferase (See Birch et al., 2008).
Predicted to be in the GT-C superfamily of
glycosyltransferases (See Liu and Mushegian, 2003).
Possible conserved integral membrane protein, equivalent
to MLC1351.25|ML1338 possible conserved integral membrane
protein from Mycobacterium leprae (440 aa), FASTA scores:
opt: 2410, E(): 5.3e-143, (82.05% identity in 434 aa
overlap); and showing some similarity with Q9CBX0|ML1504
probable conserved membrane protein from Mycobacterium
leprae (430 aa), FASTA scores: opt: 159, E(): 0.014,
(24.4% identity in 340 aa overlap). Also similar to
Q53873|SC6G4.11 putative integral membrane protein from
Streptomyces coelicolor (411 aa), FASTA scores: opt:
383,E(): 1.4e-16, (29.6% identity in 422 aa overlap); and
with weak similarity with P71061|YVFB hypothetical protein
from Bacillus subtilis (396 aa), FASTA scores: opt: 136,
E(): 0.36, (24.35% identity in 279 aa overlap); and
BAB60134|TVG1014811 hypothetical protein from Thermoplasma
volcanium (695 aa), FASTA scores: opt: 133, E():
0.85,(26.45% identity in 280 aa overlap). Shows also some
similarity with O06557|Rv1159|MTCI65.26 hypothetical 47.1
KDA protein from Mycobacterium tuberculosis (431 aa),
FASTA scores: opt: 149, E(): 0.059, (22.45% identity in
410 aa overlap); and O53515|Rv2181|MTV021.14 putative
membrane protein from Mycobacterium tuberculosis (427 aa),
FASTA scores: opt: 129, E(): 1, (24.8% identity in 367 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2673"
/db_xref="EnsemblGenomes-Tr:CCP45471"
/db_xref="GOA:P9WMZ7"
/db_xref="InterPro:IPR018584"
/db_xref="UniProtKB/Swiss-Prot:P9WMZ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45471.1"
/translation="MYGALVTAADSIRTGLGASLLAGFRPRTGAPSTATILRSALWPA
AVLSVLHRSIVLTTNGNITDDFKPVYRAVLNFRRGWDIYNEHFDYVDPHYLYPPGGTL
LMAPFGYLPFAPSRYLFISINTAAILVAAYLLLRMFNFTLTSVAAPALILAMFATETV
TNTLVFTNINGCILLLEVLFLRWLLDGRASRQWCGGLAIGLTLVLKPLLGPLLLLPLL
NRQWRALVAAVVVPVVVNVAALPLVSDPMSFFTRTLPYILGTRDYFNSSILGNGVYFG
LPTWLILFLRILFTAITFGALWLLYRYYRTGDPLFWFTTSSGVLLLWSWLVMSLAQGY
YSMMLFPFLMTVVLPNSVIRNWPAWLGVYGFMTLDRWLLFNWMRWGRALEYLKITYGW
SLLLIVTFTVLYFRYLDAKADNRLDGGIDPAWLTPEREGQR"
gene 2990706..2991116
/gene="msrB"
/locus_tag="Rv2674"
CDS 2990706..2991116
/codon_start=1
/transl_table=11
/gene="msrB"
/locus_tag="Rv2674"
/product="Probable peptide methionine sulfoxide reductase
MsrB (protein-methionine-R-oxide reductase) (peptide
met(O) reductase)"
/note="Rv2674, (MTCY441.43), len: 136 aa. Probable
msrB,peptide methionine sulfoxide reductase (See Lee et
al.,2008), highly similar to various proteins e.g.
Q9X828|SC9B1.08 putative oxidoreductase from Streptomyces
coelicolor (135 aa), FASTA scores: opt: 653, E():
1.8e-37,(71.1% identity in 128 aa overlap); O26807|MTH711
transcriptional regulator from Methanothermobacter
thermautotrophicus (151 aa), FASTA scores: opt: 533, E():
2.7e-29, (58.15% identity in 129 aa overlap);
Q9C5C8|AT4G21860 hypothetical 22.0 KDA protein from
Arabidopsis thaliana (Mouse-ear cress) (202 aa), FASTA
scores: opt: 490, E(): 2.8e-26, (54.05% identity in 124 aa
overlap); P39903|YEAA_ECOLI|B1778|Z2817|ECS2487
hypothetical protein from Escherichia coli strains K12 and
O157:H7 (137 aa), FASTA scores: opt: 426, E():
4.4e-22,(46.8% identity in 126 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2674"
/db_xref="EnsemblGenomes-Tr:CCP45472"
/db_xref="GOA:I6YA00"
/db_xref="InterPro:IPR002579"
/db_xref="InterPro:IPR011057"
/db_xref="InterPro:IPR028427"
/db_xref="UniProtKB/TrEMBL:I6YA00"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45472.1"
/translation="MTRPKLELSDDEWRQKLTPQEFHVLRRAGTERPFTGEYTDTTTA
GIYQCRACGAELFRSTEKFESHCGWPSFFDPKSSDAVTLRPDHSLGMTRTEVLCANCD
SHLGHVFAGEGYPTPTDKRYCINSISLRLVPGSV"
gene complement(2991184..2991936)
/locus_tag="Rv2675c"
CDS complement(2991184..2991936)
/codon_start=1
/transl_table=11
/locus_tag="Rv2675c"
/product="Conserved hypothetical protein"
/note="Rv2675c, (MTCY441.44c), len: 250 aa. Conserved
hypothetical protein. C-terminus highly similar to
Q50010|U1764Z from Mycobacterium leprae (69 aa), FASTA
scores: opt: 284, E(): 4.6e-11, (68.25% identity in 63 aa
overlap). Shows some similarity with Q9P3V6|SPAC1348.04
(alias Q9P3E7|Q9P7U5) hypothetical 16.6 KDA protein from
Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA
scores: opt: 203, E(): 9.5e-06, (33.05% identity in 118 aa
overlap); Q9ZSZ7|BMCT methyl chloride transferase from
Batis maritima (230 aa), FASTA scores: opt: 197, E():
3.3e-05, (28.85% identity in 156 aa overlap); P72459|STSG
methyltransferase from Streptomyces griseus (253 aa),
FASTA scores: opt: 194, E(): 5.5e-05, (24.45% identity in
229 aa overlap); etc. Also similar to various proteins
from Mycobacterium tuberculosis e.g.
P71805|Rv1377c|MTCY02B12.11c hypothetical 22.8 KDA protein
(212 aa), FASTA scores: opt: 431, E(): 8.3e-20, (39.1%
identity in 197 aa overlap); O06426|Rv0560c|MTCY25D10.39c
hypothetical 25.9 KDA protein (241 aa), FASTA scores: opt:
379, E(): 1.6e-16, (35.95% identity in 178 aa overlap);
O69667|Rv3699|MTV025.047 putative methyltransferase (233
aa), FASTA scores: opt: 297, E(): 2e-11, (30.55% identity
in 193 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2675c"
/db_xref="EnsemblGenomes-Tr:CCP45473"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:I6Y1G8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45473.1"
/translation="MTAQFDPADPTRFEEMYRDDRVAHGLPAATPWDIGGPQPVVQQL
VALGAIRGEVLDPGTGPGHHAIYYAAKGYAATGIDGSVAAIERARDNARKAGVSVNFQ
VGDATTLDGLDGRFDTVVDCAFYHTFSTAPELQRCYVRALRRASKPGARLYMFEFGEH
NVNGFSMPRSLSEDDFRQVLPVGGWEITYLGTTTYQVNLSVEALELMAARNPDMADQV
RCVLERFRAIKPWLVGGRVHAPFWEVHATRVD"
gene complement(2991933..2992628)
/locus_tag="Rv2676c"
CDS complement(2991933..2992628)
/codon_start=1
/transl_table=11
/locus_tag="Rv2676c"
/product="Conserved protein"
/note="Rv2676c, (MTCY441.45c), len: 231 aa. Conserved
protein, equivalent to Q9CCB2|ML1045 (alias Q50009|U1764Y
but longer 66 aa) hypothetical protein from Mycobacterium
leprae (231 aa), FASTA scores: opt: 1401, E():
8.7e-88,(87.45% identity in 231 aa overlap). Also highly
similar to O69830|SC1B5.02 hypothetical 28.1 KDA protein
from Streptomyces coelicolor (243 aa), FASTA scores: opt:
915,E(): 7.7e-55, (61.25% identity in 222 aa overlap); and
similar to others e.g. Q9RUB0|DR1481 conserved
hypothetical protein from Deinococcus radiodurans (289
aa), FASTA scores: opt: 327, E(): 6.1e-15, (31.8% identity
in 176 aa overlap); Q97WP2|SSO2169 hypothetical protein
from Sulfolobus solfataricus (223 aa), FASTA scores: opt:
285,E(): 3.4e-12, (31.3% identity in 163 aa overlap);
BAB59947|TVG0805714 hypothetical protein from Thermoplasma
volcanium (223 aa), FASTA scores: opt: 206, E():
7.7e-07,(25.0% identity in 176 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2676c"
/db_xref="EnsemblGenomes-Tr:CCP45474"
/db_xref="GOA:P9WL45"
/db_xref="InterPro:IPR010644"
/db_xref="InterPro:IPR011008"
/db_xref="UniProtKB/Swiss-Prot:P9WL45"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45474.1"
/translation="MARLDYDALNATLRYLMFSVFSVSPGALGDQRDAIIDDASTFFK
QQEERGVVVRGLYDVAGLRADADFMVWTHAERVEALQATYADFRRTTTLGRACTPVWS
GVGLHRPAEFNKSHIPAFLAGEEPGAYICVYPFVRSYEWYLLPDEERRRMLAEHGMAA
RGYKDVRANTVPAFALGDYEWILAFEAPELDRIVDLMRELRATDARRHTRAETPFFTG
PRVPVEQLVHSLP"
gene complement(2992634..2993992)
/gene="hemY"
/locus_tag="Rv2677c"
CDS complement(2992634..2993992)
/codon_start=1
/transl_table=11
/gene="hemY"
/locus_tag="Rv2677c"
/product="Probable protoporphyrinogen oxidase HemY
(protoporphyrinogen-IX oxidase) (protoporphyrinogenase)
(PPO)"
/note="Rv2677c, (MT2751, MTV010.01c), len: 452 aa.
Probable hemY, protoporphyrinogen oxidase, equivalent to
Q50008|PPOX_MYCLE|HEMY|ML1044 protoporphyrinogen oxidase
from Mycobacterium leprae (451 aa), FASTA scores: opt:
2211, E(): 8.8e-118, (75.4% identity in 455 aa overlap).
Also similar to others e.g. Q9RV99|DR1130 from Deinococcus
radiodurans (462 aa), FASTA scores: opt: 523, E():
2.7e-22,(29.8% identity in 453 aa overlap);
O32434|PPOX_PROFR|HEMY from Propionibacterium
freudenreichii shermanii (527 aa),FASTA scores: opt: 344,
E(): 4e-12, (32.1% identity in 495 aa overlap);
P32397|PPOX_BACSU|HEMY|HEMG from Bacillus subtilis (470
aa), FASTA scores: opt: 305, E(): 5.9e-10,(26.8% identity
in 463 aa overlap); etc. Belongs to the protoporphyrinogen
oxidase family. Cofactor: contains one FAD per homodimer."
/db_xref="EnsemblGenomes-Gn:Rv2677c"
/db_xref="EnsemblGenomes-Tr:CCP45475"
/db_xref="GOA:P9WMP1"
/db_xref="InterPro:IPR002937"
/db_xref="InterPro:IPR004572"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WMP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45475.1"
/translation="MTPRSYCVVGGGISGLTSAYRLRQAVGDDATITLFEPADRLGGV
LRTEHIGGQPMDLGAEAFVLRRPEMPALLAELGLSDRQLASTGARPLIYSQQRLHPLP
PQTVVGIPSSAGSMAGLVDDATLARIDAEAARPFTWQVGSDPAVADLVADRFGDQVVA
RSVDPLLSGVYAGSAATIGLRAAAPSVAAALDRGATSVTDAVRQALPPGSGGPVFGAL
DGGYQVLLDGLVRRSRVHWVRARVVQLERGWVLRDETGGRWQADAVILAVPAPRLARL
VDGIAPRTHAAARQIVSASSAVVALAVPGGTAFPHCSGVLVAGDESPHAKAITLSSRK
WGQRGDVALLRLSFGRFGDEPALTASDDQLLAWAADDLVTVFGVAVDPVDVRVRRWIE
AMPQYGPGHADVVAELRAGLPPTLAVAGSYLDGIGVPACVGAAGRAVTSVIEALDAQV
AR"
gene complement(2993989..2995062)
/gene="hemE"
/locus_tag="Rv2678c"
CDS complement(2993989..2995062)
/codon_start=1
/transl_table=11
/gene="hemE"
/locus_tag="Rv2678c"
/product="Probable uroporphyrinogen decarboxylase HemE
(uroporphyrinogen III decarboxylase) (URO-D) (UPD)"
/note="Rv2678c, (MTV010.02c), len: 357 aa. Probable
hemE,uroporphyrinogen decarboxylase, equivalent to
P46809|DCUP_MYCLE|heme|ML1043 uroporphyrinogen
decarboxylase from Mycobacterium leprae (357 aa), FASTA
scores: opt: 2017, E(): 8.2e-111, (83.75% identity in 357
aa overlap). Also highly similar to many e.g.
O69861|DCUP_STRCO|heme|SC1C3.19 from Streptomyces
coelicolor (355 aa), FASTA scores: opt: 1165, E():
5.6e-61,(58.15% identity in 349 aa overlap);
P32395|DCUP_BACSU|heme from Bacillus subtilis (353 aa),
FASTA scores: opt: 859,E(): 4.5e-43, (44.1% identity in
356 aa overlap); Q9RV96|DCUP_DEIRA|heme|DR1133 from
Deinococcus radiodurans (344 aa), FASTA scores: opt: 850,
E(): 1.5e-42, (43.0% identity in 349 aa overlap); etc.
Equivalent to AAK47067 from Mycobacterium tuberculosis
strain CDC1551 (372 aa) but shorter 15 aa. Contains
PS00907 Uroporphyrinogen decarboxylase signature 2.
Belongs to the uroporphyrinogen decarboxylase family."
/db_xref="EnsemblGenomes-Gn:Rv2678c"
/db_xref="EnsemblGenomes-Tr:CCP45476"
/db_xref="GOA:P9WFE1"
/db_xref="InterPro:IPR000257"
/db_xref="InterPro:IPR006361"
/db_xref="InterPro:IPR038071"
/db_xref="UniProtKB/Swiss-Prot:P9WFE1"
/inference="protein motif:PROSITE:PS00907"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45476.1"
/translation="MSTRRDLPQSPYLAAVTGRKPSRVPVWFMRQAGRSLPEYRALRE
RYSMLAACFEPDVACEITLQPIRRYDVDAAILFSDIVVPLRAAGVDLDIVADVGPVIA
DPVRTAADVAAMKPLDPQAIQPVLVAASLLVAELGDVPLIGFAGAPFTLASYLVEGGP
SRHHAHVKAMMLAEPASWHALMAKLTDLTIAFLVGQIDAGVDAIQVFDSWAGALSPID
YRQYVLPHSARVFAALGEHGVPMTHFGVGTAELLGAMSEAVTAGERPGRGAVVGVDWR
TPLTDAAARVVPGTALQGNLDPAVVLAGWPAVERAARAVVDDGRRAVDAGAAGHIFNL
GHGVLPESDPAVLADLVSLVHSL"
gene 2995115..2995945
/gene="echA15"
/locus_tag="Rv2679"
CDS 2995115..2995945
/codon_start=1
/transl_table=11
/gene="echA15"
/locus_tag="Rv2679"
/product="Probable enoyl-CoA hydratase EchA15 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv2679, (MTV010.03), len: 276 aa. Probable
echA15,enoyl-CoA hydratase, similar to
P53526|ECHC_MYCLE|ECHA12|ML1241|MLCB1610.01|B1170_C2_224
probable enoyl-CoA hydratase from Mycobacterium leprae
(294 aa), FASTA scores: opt: 368, E(): 2.5e-16, (32.15%
identity in 277 aa overlap). Also highly similar to
Q9RXX1|DR0184 from Deinococcus radiodurans (273 aa), FASTA
scores: opt: 993, E(): 2.2e-56, (58.15% identity in 263 aa
overlap); and similar to many e.g. Q9ETY7|PACA|PAAG from
Azoarcus evansii (273 aa), FASTA scores: opt: 396, E():
3.8e-18, (34.9% identity in 258 aa overlap);
O29299|AF0963|FAD-3 from Archaeoglobus fulgidus (259 aa),
FASTA scores: opt: 363,E(): 4.7e-16, (30.4% identity in
250 aa overlap); P77467|PAAG_ECOLI|B1394 from Escherichia
coli strain W (262 aa), FASTA scores: opt: 357, E():
1.1e-15, (31.75% identity in 252 aa overlap); etc. Also
similar to O53163|ECHC_MYCTU|ECHA12|FADB2|Rv1472|MT1518|MT
V007.19 enoyl-CoA hydratase from Mycobacterium
tuberculosis (285 aa), FASTA scores: opt: 355, E():
1.6e-15, (31.3% identity in 265 aa overlap); and
O06542|ECHA10|Rv1142c|MTCI65.09c|Z95584 enoyl-CoA
hydratase from Mycobacterium tuberculosis (268 aa).
Contains PS00166 Enoyl-CoA hydratase/isomerase signature.
Belongs to the enoyl-CoA hydratase/isomerase family."
/db_xref="EnsemblGenomes-Gn:Rv2679"
/db_xref="EnsemblGenomes-Tr:CCP45477"
/db_xref="GOA:I6YA03"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:I6YA03"
/inference="protein motif:PROSITE:PS00166"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45477.1"
/translation="MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRD
LADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAETIGDYQGRLRIMREARDLVLN
LVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWP
LLVGMAKAKYYLLTCEPLSGEEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIR
WTKRSLNHWYRMFGPAFETSLGLEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
"
repeat_region 2996003..2996053
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region 2996054..2996104
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 2996105..2996737
/locus_tag="Rv2680"
CDS 2996105..2996737
/codon_start=1
/transl_table=11
/locus_tag="Rv2680"
/product="Conserved protein"
/note="Rv2680, (MTV010.04), len: 210 aa. Conserved
protein,equivalent to Q50005|ML1041|U1764V hypothetical
protein from Mycobacterium leprae (196 aa), FASTA scores:
opt: 1136, E(): 9.7e-66, (83.95% identity in 193 aa
overlap). Also similar to O69860|SC1C3.18c hypothetical
24.7 KDA protein from Streptomyces coelicolor (238 aa),
FASTA scores: opt: 516, E(): 5.7e-26, (45.5% identity in
189 aa overlap); and similar in part to Q9I6V4|PA0178
probable two-component sensor from Pseudomonas aeruginosa
(639 aa),FASTA scores: opt: 120, E(): 3.1, (33.05%
identity in 115 aa overlap); and a few other proteins.
Equivalent to AAK47069 from Mycobacterium tuberculosis
strain CDC1551 (178 aa) but longer 32 aa; and N-terminus
highly similar to N-terminus of AAK48352|MT3984
hypothetical 4.2 KDA protein from Mycobacterium
tuberculosis strain CDC1551 (38 aa),FASTA scores: opt:
102, E(): 3.6, (62.05% identity in 29 aa overlap).
Nucleotide position 2996194 in the genome sequence has
been corrected, T:A resulting in V30V."
/db_xref="EnsemblGenomes-Gn:Rv2680"
/db_xref="EnsemblGenomes-Tr:CCP45478"
/db_xref="InterPro:IPR021555"
/db_xref="UniProtKB/TrEMBL:O86317"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45478.1"
/translation="MTSAGDDAERSDEEERRLTSAEPALFREAVAAMNAVTVRPEIEL
GPIRPPQRLAPYSYALGAEIKHPELDVIPERSEGDAFGRLIMLYDPDGSDAWDGTIRL
VAYVQADLDSSEAVDPLLPEVAWSWLVDALTARTDQVRALGGTVTATTSVRYGDISGP
PRAHQLELRASWTATTPDLGAHVQAFCDVLEHAAGLPPAGVTDLGSRSRA"
repeat_region 2996105..2996155
/locus_tag="Rv2680"
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 2996739..2998055
/locus_tag="Rv2681"
CDS 2996739..2998055
/codon_start=1
/transl_table=11
/locus_tag="Rv2681"
/product="Conserved hypothetical alanine rich protein"
/note="Rv2681, (MTCY05A6.02), len: 438 aa. Conserved
hypothetical ala-rich protein, equivalent to
Q50004|ML1040|U1764U hypothetical protein from
Mycobacterium leprae (429 aa), FASTA scores: opt:
2146,E(): 1.1e-119, (77.4% identity in 416 aa overlap).
Also highly similar to O69858|SC1C3.16c hypothetical 42.5
KDA protein from Streptomyces coelicolor (394 aa), FASTA
scores: opt: 1336, E(): 9e-72, (51.6% identity in 405 aa
overlap); and with some similarity to ribonucleases D e.g.
Q983F2|MLL8354 from Rhizobium loti (Mesorhizobium loti)
(383 aa), FASTA scores: opt: 379, E(): 3.9e-15, (31.6%
identity in 323 aa overlap); Q9A7L8|CC1704 from
Caulobacter crescentus (389 aa), FASTA scores: opt: 370,
E(): 1.3e-14,(31.45% identity in 318 aa overlap); CAC45770
from Rhizobium meliloti (Sinorhizobium meliloti) (383 aa),
FASTA scores: opt: 331, E(): 2.7e-12, (27.75% identity in
357 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2681"
/db_xref="EnsemblGenomes-Tr:CCP45479"
/db_xref="GOA:I6XF17"
/db_xref="InterPro:IPR002121"
/db_xref="InterPro:IPR002562"
/db_xref="InterPro:IPR010997"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR041605"
/db_xref="UniProtKB/TrEMBL:I6XF17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45479.1"
/translation="MCPEPSHAGAAESEGTESEPTPLLRPAGGIPDLCVTVGEIAAAA
ELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLIDPVSHGGDPLTVLAPVA
EVLSTNEWILHSADQDLPCLAEVGMRPPALYDTELAGRLAGFDRVNLAAMVERLLGLG
LTKGHGAADWSKRPLPSAWLNYAALDVELLIELRAAISRVLAEQGKTDWAAQEFEHLR
SFESRPPPAAARQDRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPD
SAIIDAAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPANGP
PPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRLCWEWEDISQSS
PDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAGAQGDDGS"
gene complement(2998052..2999968)
/gene="dxs1"
/gene_synonym="dxs"
/locus_tag="Rv2682c"
CDS complement(2998052..2999968)
/codon_start=1
/transl_table=11
/gene="dxs1"
/gene_synonym="dxs"
/locus_tag="Rv2682c"
/product="Probable 1-deoxy-D-xylulose 5-phosphate synthase
Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase)
(DXPS)"
/note="Rv2682c, (MTCY05A6.03c), len: 638 aa. Probable
dxs1,1-deoxy-D-xylulose 5-phosphate synthase, equivalent
to Q50000|DXS_MYCLE|TKTB|ML1038 1-deoxy-D-xylulose
5-phosphate synthase from Mycobacterium leprae (643 aa),
FASTA scores: opt: 3635, E(): 5.6e-209, (86.4% identity in
632 aa overlap). Also highly similar to other
Q9X7W3|DXS_STRCO|DXS|SC6A5.17 from Streptomyces coelicolor
(656 aa), FASTA scores: opt: 2501, E(): 2e-141, (61.3%
identity in 623 aa overlap); Q9K971|DXS_BACHD|DXS|BH2779
from Bacillus halodurans (629 aa), FASTA scores: opt:
1612,E(): 1.8e-88, (41.35% identity in 619 aa overlap);
P77488|DXS_ECOLI|DXS|B0420 from Escherichia coli strain
K12 (619 aa), FASTA scores: opt: 1511, E(): 1.8e-82,
(39.5% identity in 625 aa overlap); etc. Also similar to
O50408|Rv3379c|MTV004.37c from Mycobacterium tuberculosis
(536 aa). Belongs to the transketolase family. DXS
subfamily. Cofactor: thiamine pyrophosphate. Note that
previously known as dxs."
/db_xref="EnsemblGenomes-Gn:Rv2682c"
/db_xref="EnsemblGenomes-Tr:CCP45480"
/db_xref="GOA:P9WNS3"
/db_xref="InterPro:IPR005474"
/db_xref="InterPro:IPR005475"
/db_xref="InterPro:IPR005477"
/db_xref="InterPro:IPR009014"
/db_xref="InterPro:IPR020826"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR033248"
/db_xref="UniProtKB/Swiss-Prot:P9WNS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45480.1"
/translation="MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPN
LGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPSRA
ESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIA
ASRRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLW
FRFLHSVKAGIKDSLSPQLLFTDLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHV
VTRKGMGYPPAEADQAEQMHSTVPIDPATGQATKVAGPGWTATFSDALIGYAQKRRDI
VAITAAMPGPTGLTAFGQRFPDRLFDVGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLN
RAFDQIMMDVALHKLPVTMVLDRAGITGSDGASHNGMWDLSMLGIVPGIRVAAPRDAT
RLREELGEALDVDDGPTALRFPKGDVGEDISALERRGGVDVLAAPADGLNHDVLLVAI
GAFAPMALAVAKRLHNQGIGVTVIDPRWVLPVSDGVRELAVQHKLLVTLEDNGVNGGA
GSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSEVLADLGLTDQDVARRITGWVAALG
TGVCASDAIPEHLD"
gene 3000112..3000609
/locus_tag="Rv2683"
CDS 3000112..3000609
/codon_start=1
/transl_table=11
/locus_tag="Rv2683"
/product="Conserved protein"
/note="Rv2683, (MTCY05A6.04), len: 165 aa. Conserved
protein, equivalent, but shorter 19 aa, to
Q49999|ML1037|U1764Q hypothetical protein from
Mycobacterium leprae (184 aa), FASTA scores: opt: 750,
E(): 1.2e-41, (73.8% identity in 164 aa overlap). Shows
some similarity with other hypothetical proteins e.g.
Q988S9|MLL6611 from Rhizobium loti (Mesorhizobium loti)
(232 aa), FASTA scores: opt: 128, E(): 0.25, (25.5%
identity in 149 aa overlap); Q9YFL5|APE0233 from Aeropyrum
pernix (340 aa), FASTA scores: opt: 123, E(): 0.73, (29.1%
identity in 141 aa overlap); BAB60477|TVG1377730 from
Thermoplasma volcanium (174 aa), FASTA scores: opt:
118,E(): 0.86, (28.8% identity in 59 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2683"
/db_xref="EnsemblGenomes-Tr:CCP45481"
/db_xref="InterPro:IPR000644"
/db_xref="UniProtKB/TrEMBL:I6X540"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45481.1"
/translation="MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARML
AEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLS
GKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLA
AALKT"
gene 3000614..3001903
/gene="arsA"
/locus_tag="Rv2684"
CDS 3000614..3001903
/codon_start=1
/transl_table=11
/gene="arsA"
/locus_tag="Rv2684"
/product="Probable arsenic-transport integral membrane
protein ArsA"
/note="Rv2684, (MTCY05A6.05), len: 429 aa. Probable
arsA,arsenic-transport integral membrane protein,
equivalent to P46838|AG45_MYCLE|ML1036 46 KDA probable
integral membrane protein (antigen 45, a transmembrane
protein related to arsenical pumps) from Mycobacterium
leprae (429 aa), FASTA scores: opt: 2067, E(): 9.9e-118,
(74.05% identity in 428 aa overlap); and upstream orf
O07187|YQ85_MYCTU|ARSB|Rv2685|MT2759|MTCY05A6.06 probable
integral membrane 45.2 KDA protein ARSB from Mycobacterium
tuberculosis (428 aa), FASTA scores: opt: 2148, E():
1.3e-122, (76.58% identity in 427 aa overlap). Also highly
similar to other proteins e.g. Q9UY19|PAB1107 transport
protein from Pyrococcus abyssi (425 aa), FASTA scores:
opt: 1109, E(): 8.3e-60, (41.45% identity in 427 aa
overlap); O59575|PH1912 hypothetical 46.0 KDA protein from
Pyrococcus horikoshii (424 aa), FASTA scores: opt: 1101,
E(): 2.5e-59,(41.95% identity in 429 aa overlap);
Q9KDI2|BH1231 hypothetical 46.0 KDA protein from Bacillus
halodurans (428 aa), FASTA scores: opt: 1018, E():
2.7e-54, (38.9% identity in 427 aa overlap); etc. Belongs
to the NADC/P/PHO87 family of transporters, P subfamily
(ARS family)."
/db_xref="EnsemblGenomes-Gn:Rv2684"
/db_xref="EnsemblGenomes-Tr:CCP45482"
/db_xref="GOA:P9WPD9"
/db_xref="InterPro:IPR000802"
/db_xref="InterPro:IPR004680"
/db_xref="UniProtKB/Swiss-Prot:P9WPD9"
/protein_id="CCP45482.1"
/translation="MSVVAVTIFVAAYVLIASDRVNKTMVALTGAAAVVVLPVITSHD
IFYSHDTGIDWDVIFLLVGMMIIVGVLRQTGVFEYTAIWAAKRARGSPLRIMILLVLV
SALASALLDNVTTVLLIAPVTLLVCDRLNINTTSFLMAEVFASNIGGAATLVGDPPNI
IVASRAGLTFNDFMLHLTPLVVIVLIALIAVLPRLFGSITVEADRIADVMALDEGEAI
RDRGLLVKCGAVLVLVFAAFVAHPVLHIQPSLVALLGAGMLIVVSGLTRSEYLSSVEW
DTLLFFAGLFIMVGALVKTGVVNDLARAATQLTGGNIVATAFLILGVSAPISGIIDNI
PYVATMTPLVAELVAVMGGQPSTDTPWWALALGADFGGNLTAIGASANVVMLGIARRA
GAPISFWEFTRKGAVVTAVSIALAAIYLWLRYFVLLH"
gene 3001983..3003269
/gene="arsB1"
/gene_synonym="arsB"
/locus_tag="Rv2685"
CDS 3001983..3003269
/codon_start=1
/transl_table=11
/gene="arsB1"
/gene_synonym="arsB"
/locus_tag="Rv2685"
/product="Probable arsenic-transport integral membrane
protein ArsB1"
/note="Rv2685, (MTCY05A6.06), len: 428 aa. Probable
arsB1,arsenic-transport integral membrane protein,
equivalent to P46838|AG45_MYCLE|ML1036 46 KDA probable
integral membrane protein (antigen 45, a transmembrane
protein related to arsenical pumps) from Mycobacterium
leprae (429 aa), FASTA scores: opt: 2048, E(): 7.3e-120,
(74.25% identity in 427 aa overlap); and downstream ORF
O07186|YQ84_MYCTU|ARSA|Rv2684|MT2758|MTCY05A6.05 probable
integral membrane protein ARSA from Mycobacterium
tuberculosis (429 aa), FASTA scores: opt: 2154, E():
1.9e-126, (76.8% identity in 427 aa overlap). Also highly
similar to other proteins e.g. O59575|PH1912 hypothetical
46.0 KDA protein from Pyrococcus horikoshii (424 aa),
FASTA scores: opt: 1075, E(): 1.9e-59, (43.55% identity in
427 aa overlap); Q9UY19|PAB1107 transport protein from
Pyrococcus abyssi (425 aa), FASTA scores: opt: 1062, E():
1.3e-58,(41.8% identity in 428 aa overlap); Q9KDI2|BH1231
hypothetical 46.0 KDA protein from Bacillus halodurans
(428 aa), FASTA scores: opt: 993, E(): 2.4e-54, (39.55%
identity in 430 aa overlap); etc. Belongs to the
NADC/P/PHO87 family of transporters, P subfamily. Note
that previously known as arsB."
/db_xref="EnsemblGenomes-Gn:Rv2685"
/db_xref="EnsemblGenomes-Tr:CCP45483"
/db_xref="GOA:P9WPD7"
/db_xref="InterPro:IPR000802"
/db_xref="InterPro:IPR004680"
/db_xref="UniProtKB/Swiss-Prot:P9WPD7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45483.1"
/translation="MSIIAITVFVAGYALIASDRVSKTRVALTCAAIMVGAGIVGSDD
VFYSHEAGIDWDVIFLLLGMMIIVSVLRHTGVFEYVAIWAVKRANAAPLRIMILLVLV
TALGSALLDNVTTVLLIAPVTLLVCDRLGVNSTPFLVAEVFASNVGGAATLVGDPPNI
IIASRAGLTFNDFLIHMAPAVLVVMIALIGLLPWLLGSVTAEPDRVADVLSLNEREAI
HDRGLLIKCGVVLVLVFAAFIAHPVLHIQPSLVALLGAGVLVRFSGLERSDYLSSVEW
DTLLFFAGLFVMVGALVKTGVVEQLARAATELTGGNELLTVGLILGISAPVSGIIDNI
PYVATMTPIVTELVAAMPGHVHPDTFWWALALSADFGGNLTAVAASANVVMLGIARRS
GTPISFWKFTRKGAVVTAVSLVLSAVYLWLRYFVFG"
gene complement(3003280..3004038)
/locus_tag="Rv2686c"
CDS complement(3003280..3004038)
/codon_start=1
/transl_table=11
/locus_tag="Rv2686c"
/product="Antibiotic-transport integral membrane leucine
and alanine and valine rich protein ABC transporter"
/note="Rv2686c, (MTCY05A6.07c), len: 252 aa.
Antibiotic-transport integral membrane leu-, ala-,
val-rich protein ABC transporter (see citation below). The
region from aa ~115 to 160 is highly similar to N-terminus
of Q49998|U1764P hypothetical protein from Mycobacterium
leprae (53 aa), FASTA scores: opt: 151, E(): 0.011,
(58.15% identity in 43 aa overlap). Shows some similarity
with membrane proteins e.g. AAK75541|SP1447 membrane
protein from Streptococcus pneumoniae (298 aa), FASTA
scores: opt: 139, E(): 0.21, (29.65% identity in 135 aa
overlap); Q9K4C9|2SC6G5.26c putative ABC transporter
integral membrane subunit from Streptomyces coelicolor
(249 aa),FASTA scores: opt: 138, E(): 0.21, (26.9%
identity in 253 aa overlap); Q53627|MTRB membrane protein
involved in mithramycin resistance from Streptomyces
argillaceus (233 aa), FASTA scores: opt: 136, E(): 0.27,
(26.7% identity in 191 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2686c"
/db_xref="EnsemblGenomes-Tr:CCP45484"
/db_xref="GOA:P9WJB3"
/db_xref="UniProtKB/Swiss-Prot:P9WJB3"
/protein_id="CCP45484.1"
/translation="MRAISSLAGPRALAAFGRNDIRGTYRDPLLVMLVIAPVIWTTGV
ALLTPLFTEMLARRYGFDLVGYYPLILTAFLLLTSIIVAGALAAFLVLDDVDAGTMTA
LRVTPVPLSVFFGYRAATVMVVTTIYVVATMSCSGILEPGLVSSLIPIGLVAGLSAVV
TLLLILAVANNKIQGLAMVRALGMLIAGLPCLPWFISSNWNLAFGVLPPYWAAKAFWV
ASDHGTWWPYLVGGAVYNLAIVWVLFRRFRAKHA"
gene complement(3004035..3004748)
/locus_tag="Rv2687c"
CDS complement(3004035..3004748)
/codon_start=1
/transl_table=11
/locus_tag="Rv2687c"
/product="Antibiotic-transport integral membrane leucine
and valine rich protein ABC transporter"
/note="Rv2687c, (MTCY05A6.08c), len: 237 aa.
Antibiotic-transport integral membrane leu-, val-rich
protein ABC transporter (see citation below), showing some
similarity with two other hypothetical
proteins,BAB59668|TVG0517148 from Thermoplasma volcanium
(241 aa),FASTA scores: opt: 136, E(): 0.32, (23.1%
identity in 208 aa overlap); and Q97U55|SSO3168 from
Sulfolobus solfataricus (249 aa), FASTA scores: opt: 136,
E(): 0.33,(25.15% identity in 195 aa overlap). Has some
hydrophobic stretches and contains bacterial regulatory
proteins, araC family signature (PS00041)."
/db_xref="EnsemblGenomes-Gn:Rv2687c"
/db_xref="EnsemblGenomes-Tr:CCP45485"
/db_xref="GOA:P9WJB1"
/db_xref="UniProtKB/Swiss-Prot:P9WJB1"
/inference="protein motif:PROSITE:PS00041"
/protein_id="CCP45485.1"
/translation="MTRLVPALRLELTLQVRQKFLHAAVFSGLIWLAVLLPMPVSLRP
VAEPYVLVGDIAIIGFFFVGGTVFFEKQERTIGAIVSTPLRFWEYLAAKLTVLLAISL
FVAVVVATIVHGLGYHLLPLVAGIVLGTLLMLLVGFSSSLPFASVTDWFLAAVIPLAI
MLAPPVVHYSGLWPNPVLYLIPTQGPLLLLGAAFDQVSLAPWQVGYAVVYPIVCAAGL
CRAAKALFGRYVVQRSGVL"
gene complement(3004745..3005650)
/locus_tag="Rv2688c"
CDS complement(3004745..3005650)
/codon_start=1
/transl_table=11
/locus_tag="Rv2688c"
/product="Antibiotic-transport ATP-binding protein ABC
transporter"
/note="Rv2688c, (MTCY05A6.09c), len: 301 aa.
Antibiotic-transport ATP-binding protein ABC transporter
(see citation below), highly similar to AAK47077|MT2762
ABC transporter ATP-binding protein from Mycobacterium
tuberculosis strain CDC1551 (317 aa), FASTA scores: opt:
1714, E(): 5.1e-93, (95.6% identity in 274 aa overlap).
Also highly similar to other ATP-binding proteins ABC
transporter e.g. Q9K639|BH3893 from Bacillus halodurans
(282 aa), FASTA scores: opt: 644, E(): 1.4e-30, (38.%
identity in 285 aa overlap); O58550|PH0820 from Pyrococcus
horikoshii (312 aa), FASTA scores: opt: 574, E():
1.8e-26,(39.1% identity in 307 aa overlap); Q9WYM0|TM0389
from Thermotoga maritima (301 aa), FASTA scores: opt: 536,
E(): 2.9e-24, (36.1% identity in 291 aa overlap); etc. Has
ATP/GTP-binding site motif A (P-loop) at N-terminus
(PS00017). Belongs to the ATP-binding transport protein
family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv2688c"
/db_xref="EnsemblGenomes-Tr:CCP45486"
/db_xref="GOA:P9WQL7"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQL7"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45486.1"
/translation="MTALNRAVASARVGTEVIRVRGLTFRYPKAAEPAVRGMEFTVGR
GEIFGLLGPSGAGKSTTQKLLIGLLRDHGGQATVWDKEPAEWGPDYYERIGVSFELPN
HYQKLTGYENLRFFASLYAGATADPMQLLAAVGLADDAHTLVGKYSKGMQMRLPFARS
LINDPELLFLDEPTSGLDPVNARKIKDIIVDLKARGRTIFLTTHDMATADELCDRVAF
VVDGRIVALDSPTELKIARSRRRVRVEYRGDGGGLETAEFGMDGLADDPAFHSVLRNH
HVETIHSREASLDDVFVEVTGRQLT"
gene complement(3005845..3007062)
/locus_tag="Rv2689c"
CDS complement(3005845..3007062)
/codon_start=1
/transl_table=11
/locus_tag="Rv2689c"
/product="Conserved alanine and valine and glycine rich
protein"
/note="Rv2689c, (MTCY05A6.10c), len: 405 aa (other less
probable starts possible). Conserved ala-, val-, gly-rich
protein, similar to O54099|SC10A5.06 hypothetical 49.5 KDA
protein from Streptomyces coelicolor (458 aa), FASTA
scores: opt: 455, E(): 2.7e-20, (38.35% identity in 417 aa
overlap); and shows weak similarity in part with several
methyltransferases e.g. Q9X0H9|TM1094 putative RNA
methyltransferase from Thermotoga maritima (439 aa), FASTA
scores: opt: 306, E(): 3e-11, (25.9% identity in 436 aa
overlap); AK79403|CAC1435 S-adenosylmethionine-dependent
methyltransferases from Clostridium acetobutylicum (456
aa), FASTA scores: opt: 294, E(): 1.6e-10, (23.4% identity
in 449 aa overlap); Q9A8M7|CC1326 RNA methyltransferase
from Caulobacter crescentus (415 aa), FASTA scores: opt:
247, E(): 1.1e-07, (28.4% identity in 433 aa overlap);
etc. Equivalent to AAK47078 from Mycobacterium
tuberculosis strain CDC1551 (434 aa) but shorter 29 aa."
/db_xref="EnsemblGenomes-Gn:Rv2689c"
/db_xref="EnsemblGenomes-Tr:CCP45487"
/db_xref="GOA:O07191"
/db_xref="InterPro:IPR002792"
/db_xref="InterPro:IPR010280"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:O07191"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45487.1"
/translation="MTRAGDDAVNLTLVTGAPANGGSCVAHHEGRVVFVRYALPGERV
RARVTAQRGSYWHAEAFEVIDPSPDRIGSLCSIAGADGAGCCDLAFAAPEAARTLKAQ
VVANQLERLGRHSWQGEAQPLSDAGPTGWRIRVRLDVGADRRPGFHRYHSGELVTDLD
CGQLPVGMLDGLVAADWPPEAQLYVALDDDGERHVVCSVRQGPRNRTRTVTNVVEGAY
HAHQRVHRRSWRVPVTAFWQAHRDAAAVYSDLIADWAQPAPGMTAWDLYGGAGVFAAV
LGEAVGESGRVLTVDTSRLASGAARAALVDLPQVEVVTGSVRRVLAVQPAGADLAVLD
PPRSGAGREVVDLLAGAGVPRLIHIGCEAASFARDIGLYRGHGYAVEKIKVFDAFPLT
HYVECVALLTRKV"
repeat_region complement(3007063..3007115)
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(3007116..3007168)
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(3007169..3007221)
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene complement(3007236..3009209)
/locus_tag="Rv2690c"
CDS complement(3007236..3009209)
/codon_start=1
/transl_table=11
/locus_tag="Rv2690c"
/product="Probable conserved integral membrane alanine and
valine and leucine rich protein"
/note="Rv2690c, (MTCY05A6.11c), len: 657 aa. Probable
conserved integral membrane ala-, val-, leu-rich
protein,highly similar to others e.g. O54098|SC10A5.05
putative membrane protein from Streptomyces coelicolor
(691 aa),FASTA scores: opt: 2007, E(): 1.6e-116, (62.35%
identity in 669 aa overlap); O69917|SC3C8.04c putative
integral membrane protein from Streptomyces coelicolor
(644 aa),FASTA scores: opt: 923, E(): 1.7e-49, (35.3%
identity in 669 aa overlap); AAK78253|CAC0272 amino acid
transporter from Clostridium acetobutylicum (620 aa),
FASTA scores: opt: 674, E(): 4.1e-34, (36.55% identity in
640 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2690c"
/db_xref="EnsemblGenomes-Tr:CCP45488"
/db_xref="GOA:I6Y1H7"
/db_xref="InterPro:IPR002293"
/db_xref="UniProtKB/TrEMBL:I6Y1H7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45488.1"
/translation="MSKLSTAARRLLIGRPFRSDRLSHTLLPKRIALPVFASDAMSSI
AYAPEEIFLVLSVAGLAAYSMAPLIGLAVAAVLLVVVSSYRQNVHAYPSGGGDYEVVT
TNLGATGGLVVASALMVDYVLTVAVSISSAASNIGSVSPFVYEHKVLFAVGAIVLIMA
MNLRGVRESGLAFAIPTYAFIAGIGTMLVWGLFRIFVLGNPVRAESAAFEMHAEHGQI
VGFALVFLVARSFSSGCAALTGVEAISNGVPAFQKPKSRNAATTLLMLGIIAVSMFMG
MIVLAVETGVQVVDDPDTQLTGAPPGYQQKTLVAQLAQAVFGGFYLGFLLIAAVTALI
LVLAANTAFNGFPVLGSVLAQHSYLPRQLHTRGDRLAFSNGILFLAAAAIGAVVAFRA
ELTALIQLYIVGVFISFTMSQVGMVRHWTRLLSAETDPRARRAMLRSRAVNTVGFVST
GTVLLIVLVTKFLAGAWIAIVAMGGFFMMMKLIHRHYDAVNRELAEQAEEAEITLPSR
NHAVVLVSKLHLPTLRALTYARATRPDVLEAVTVNVDDAETRELVRQWQDSDVSVPLK
VIASPYREITRPVLDYVKRVSKESPRTVVTVFIPEYVVGRWWEQLLHNQSALRLKGRL
LFMPGVMVTSVPWQLTSSERIKTLQPHAAPGDT"
gene 3009344..3010027
/gene="ceoB"
/gene_synonym="trkA"
/locus_tag="Rv2691"
CDS 3009344..3010027
/codon_start=1
/transl_table=11
/gene="ceoB"
/gene_synonym="trkA"
/locus_tag="Rv2691"
/product="TRK system potassium uptake protein CeoB"
/note="Rv2691, (MTCY05A6.12), len: 227 aa. CeoB (alternate
gene name: trkA), TRK system potassium uptake protein (see
citation below), highly similar to others e.g.
Q53949|TRKA_STRCO|SC2E9.17c from Streptomyces coelicolor
(223 aa), FASTA scores: opt: 781, E(): 5.8e-42, (53.2%
identity in 220 aa overlap); O27333|TRKA_METTH|MTH1265
from Methanobacterium thermoautotrophicum (216 aa), FASTA
scores: opt: 287, E(): 5.3e-11, (27.0% identity in 211 aa
overlap); O54141|SC2E9.16c from Streptomyces coelicolor
(226 aa), FASTA scores: opt: 269, E(): 7.3e-10, (29.9%
identity in 214 aa overlap); etc. Also similar to upstream
orf O07194|CEOC|TRKA_MYCTU|TRKA|TRKB|Rv2692|MT2766|MTCY05A
6.13 TRK system potassium uptake protein from
Mycobacterium tuberculosis (220 aa), FASTA scores: opt:
259, E(): 3e-09,(26.55% identity in 226 aa overlap).
Contains a motif common to NAD+ binding pockets (see
citation below). Belongs to the TrkA family."
/db_xref="EnsemblGenomes-Gn:Rv2691"
/db_xref="EnsemblGenomes-Tr:CCP45489"
/db_xref="GOA:I6XF25"
/db_xref="InterPro:IPR003148"
/db_xref="InterPro:IPR006036"
/db_xref="InterPro:IPR006037"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036721"
/db_xref="UniProtKB/TrEMBL:I6XF25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45489.1"
/translation="MRVVVMGCGRVGASVADGLSRIGHEVAIIDRDSAAFNRLSPQFA
GERVLGQGFDRDVLLRAGIQGADAFAAVSSGDNSNIISARLARETFGVPRVVARIYDA
KRAEVYERLGIPTITTVPWTTDRLLNALMQDTETAKWRDPTGTVAVAEVVLHEDWVGH
RATDLEQATGARIAFLIRFGTGVLPEPKTVLQAGDKVYIAAISGRAAEAAAIAALPPS
EDFESGARR"
gene 3010024..3010686
/gene="ceoC"
/gene_synonym="trkA"
/gene_synonym="trkB"
/locus_tag="Rv2692"
CDS 3010024..3010686
/codon_start=1
/transl_table=11
/gene="ceoC"
/gene_synonym="trkA"
/gene_synonym="trkB"
/locus_tag="Rv2692"
/product="TRK system potassium uptake protein CeoC"
/note="Rv2692, (MTCY05A6.13), len: 220 aa. CeoC (alternate
gene names: trkA and trkB), TRK system potassium uptake
protein (see citation below), highly similar to others
e.g. O54141|SC2E9.16c from Streptomyces coelicolor (226
aa),FASTA scores: opt: 870, E(): 9.4e-48, (58.8% identity
in 216 aa overlap); Q58505|TRKA_METJA|MJ1105 from
Methanococcus jannaschii (218 aa), FASTA scores: opt:
361,E(): 9.7e-16, (29.8% identity in 218 aa overlap);
O27333|TRKA_METTH|MTH1265 from Methanobacterium
thermoautotrophicum (216 aa), FASTA scores: opt: 326, E():
1.5e-13, (30.1% identity in 216 aa overlap); etc. Also
similar to downstream orf
O07193|CEOB|TRKA|Rv2691|MTCY05A6.12 TRK system potassium
uptake protein from Mycobacterium tuberculosis (227
aa),FASTA scores: opt: 259, E(): 2.6e-09, (26.55% identity
in 226 aa overlap). Contains a motif common to NAD+
binding pockets (see citation below). Belongs to the TrkA
family."
/db_xref="EnsemblGenomes-Gn:Rv2692"
/db_xref="EnsemblGenomes-Tr:CCP45490"
/db_xref="GOA:P9WFZ3"
/db_xref="InterPro:IPR003148"
/db_xref="InterPro:IPR006036"
/db_xref="InterPro:IPR006037"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036721"
/db_xref="UniProtKB/Swiss-Prot:P9WFZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45490.1"
/translation="MKVAVAGAGAVGRSVTRELVENGHDITLIERNPDHLDAAAIPEA
HWRLGDACELSLLESIHLEEFDVVVAATGDDKVNVVLSLLAKTEFAVPRVVARVNDPR
NEWLFNDAWGVDVAVSTPRMLASLIEEAVTIGDLVRLMEFRTGQANLVEITLPDNTPW
GGKPVRKLQLPRDAALVTILRGPRVIVPEADEPLEGGDELLFVAVTEAEEELSRLLLP
SM"
gene complement(3010697..3011368)
/locus_tag="Rv2693c"
CDS complement(3010697..3011368)
/codon_start=1
/transl_table=11
/locus_tag="Rv2693c"
/product="Probable conserved integral membrane alanine and
leucine rich protein"
/note="Rv2693c, (MTCY05A6.14c), len: 223 aa. Probable
conserved integral membrane ala-, leu-rich protein,
showing some similarity to O54140|SC2E9.15 hypothetical
29.6 KDA protein from Streptomyces coelicolor (272 aa),
FASTA scores: opt: 212, E(): 4.3e-06, (23.5% identity in
247 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2693c"
/db_xref="EnsemblGenomes-Tr:CCP45491"
/db_xref="GOA:I6X548"
/db_xref="InterPro:IPR016566"
/db_xref="UniProtKB/TrEMBL:I6X548"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45491.1"
/translation="MNANRTSAQRLLAQAGGVSGLVYSSLPVVTFVVASSAAGLLPAI
GFALSMAGLILLWRLLRRESARPVVAGFCGVAVCALIAYLVGQSKGYFLLGIWMSLLW
AVVFTLSILIRRPIVGYLWSWLSGRDRAWRDVSRAVFAFDVATLGWTLVFAARFIVQR
HLYDADKTGWLGVARIGMGWPLTALAALATYAAIKAAQRAILASHDAAAVGGAAEFDA
DAGRE"
gene complement(3011399..3011767)
/locus_tag="Rv2694c"
CDS complement(3011399..3011767)
/codon_start=1
/transl_table=11
/locus_tag="Rv2694c"
/product="Conserved protein"
/note="Rv2694c, (MTCY05A6.15c), len: 122 aa. Conserved
protein, highly similar in part to SC2E9.14 hypothetical
16.9 KDA protein from Streptomyces coelicolor (154
aa),FASTA scores: opt: 299, E(): 1.9e-13, (41.05% identity
in 117 aa overlap. Equivalent to AAK47083 from
Mycobacterium tuberculosis strain CDC1551 (157 aa) but
shorter 35 aa."
/db_xref="EnsemblGenomes-Gn:Rv2694c"
/db_xref="EnsemblGenomes-Tr:CCP45492"
/db_xref="InterPro:IPR016499"
/db_xref="UniProtKB/TrEMBL:O07196"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45492.1"
/translation="MGAQGYLRRLTRRLTEDLEQRDVEELSDEVLNAGAQRAIDCQRG
QEVTVVGTLRSVETNGKGCSGGVRAELFDGSDTVTLVWLGQRRIPGIDTGRTLRVRGR
LGKLENGTKAIYNPHYEIQR"
gene 3011916..3012623
/locus_tag="Rv2695"
CDS 3011916..3012623
/codon_start=1
/transl_table=11
/locus_tag="Rv2695"
/product="Conserved hypothetical alanine rich protein"
/note="Rv2695, (MTCY05A6.16), len: 235 aa. Conserved
hypothetical ala-rich protein, equivalent to
Q49994|ML1030|U1764L hypothetical protein from
Mycobacterium leprae (232 aa), FASTA scores: opt:
1166,E(): 6.3e-63, (76.95% identity in 230 aa overlap).
Also shows some similarity with other hypothetical
proteins e.g. Q986S2|MLR7232 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (277 aa), FASTA
scores: opt: 150, E(): 0.059, (33.55% identity in 173 aa
overlap); CAC47772|SMC03810 hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) (269 aa),
FASTA scores: opt: 143, E(): 0.15, (28.05% identity in 228
aa overlap); Q9A5N6|CC2411 3-oxoadipate enol-lactone
hydrolase/4-carboxymuconolactone decarboxylase from
Caulobacter crescentus (393 aa), FASTA scores: opt:
138,E(): 0.41, (26.45% identity in 238 aa overlap); etc. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004). Nucleotide position
3012293 in the genome sequence has been corrected, A:G
resulting in T126T."
/db_xref="EnsemblGenomes-Gn:Rv2695"
/db_xref="EnsemblGenomes-Tr:CCP45493"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6Y1I1"
/inference="protein motif:PROSITE:PS00343"
/protein_id="CCP45493.1"
/translation="MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPH
PGRLIDGYRAALDDAARDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEP
ELAPAAQAARYTAARLRCDGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEA
AAYVAPSRAELARLVAPLAVAAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADA
AALGSACLAALAEVSGA"
gene complement(3012829..3013608)
/locus_tag="Rv2696c"
CDS complement(3012829..3013608)
/codon_start=1
/transl_table=11
/locus_tag="Rv2696c"
/product="Conserved alanine and glycine and valine rich
protein"
/note="Rv2696c, (MTCY05A6.17c), len: 259 aa. Conserved
ala-, gly-, val-rich protein, equivalent (but shorter 18
aa) to Q49993|ML1029|U1764K hypothetical protein from
Mycobacterium leprae (273 aa), FASTA scores: opt:
1174,E(): 2.1e-63, (70.6% identity in 262 aa overlap).
Also similar to O54135|SC2E9.10 from Streptomyces
coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06,
(28.25% identity in 255 aa overlap); and showing weak
similarity with other proteins."
/db_xref="EnsemblGenomes-Gn:Rv2696c"
/db_xref="EnsemblGenomes-Tr:CCP45494"
/db_xref="InterPro:IPR022183"
/db_xref="UniProtKB/TrEMBL:I6XF31"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45494.1"
/translation="MAFGRRTGKDGGKRKAGHAPVQPADEHVRPEDTVVASAAAASGV
EDQEELQGPFDIDDFDDPSVAVLARLDLGSVLIPMPAAGQVQVELTESGVPSAVWVIT
PNGRYSIAAYAAPKTGGLWREVAGELADSLRKDSAKVSIKDGPWGREVIGIAAGVVRF
IGVDGYRWMIRCVVNGPQETVDALTEEAREALADTVVRRGDTPLPVRTPLPVHLPEPM
AAQLREAAAAQADTQRQAAAGVARRGAQGSAMQQLRSTTGG"
repeat_region complement(3013612..3013687)
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class I"
gene complement(3013683..3014147)
/gene="dut"
/locus_tag="Rv2697c"
CDS complement(3013683..3014147)
/codon_start=1
/transl_table=11
/gene="dut"
/locus_tag="Rv2697c"
/product="Probable deoxyuridine 5'-triphosphate
nucleotidohydrolase Dut (dUTPase) (dUTP pyrophosphatase)
(deoxyuridine 5'-triphosphatase) (dUTP diphosphatase)
(deoxyuridine-triphosphatase)"
/note="Rv2697c, (MT2771, MTCY05A6.18c), len: 154 aa.
Probable dut, deoxyuridine 5'-triphosphate
nucleotidohydrolase (see citation below), equivalent to
Q49992|DUT_MYCLE|ML1028 deoxyuridine 5'-triphosphate
nucleotidohydrolase from Mycobacterium leprae (154
aa),FASTA scores: opt: 928, E(): 2.1e-51, (90.25% identity
in 154 aa overlap). Also highly similar to others e.g.
O54134|DUT_STRCO|SC2E9.09 from Streptomyces coelicolor
(183 aa), FASTA scores: opt: 534, E(): 1.2e-26, (56.1%
identity in 148 aa overlap); O66592|DUT_AQUAE|AQ_220 from
Aquifex aeolicus (150 aa), FASTA scores: opt: 398, E():
3.3e-18,(48.05% identity in 152 aa overlap);
Q9X3X5|DUT_ZYMMO from Zymomonas mobilis (146 aa), FASTA
scores: opt: 396, E(): 4.4e-18, (49.0% identity in 147 aa
overlap); etc. Belongs to the dUTPase family."
/db_xref="EnsemblGenomes-Gn:Rv2697c"
/db_xref="EnsemblGenomes-Tr:CCP45495"
/db_xref="GOA:P9WNS5"
/db_xref="InterPro:IPR008181"
/db_xref="InterPro:IPR029054"
/db_xref="InterPro:IPR033704"
/db_xref="InterPro:IPR036157"
/db_xref="PDB:1MQ7"
/db_xref="PDB:1SIX"
/db_xref="PDB:1SJN"
/db_xref="PDB:1SLH"
/db_xref="PDB:1SM8"
/db_xref="PDB:1SMC"
/db_xref="PDB:1SNF"
/db_xref="PDB:2PY4"
/db_xref="PDB:3H6D"
/db_xref="PDB:3HZA"
/db_xref="PDB:3I93"
/db_xref="PDB:3LOJ"
/db_xref="PDB:4GCY"
/db_xref="PDB:5ECT"
/db_xref="PDB:5EDD"
/db_xref="UniProtKB/Swiss-Prot:P9WNS5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45495.1"
/translation="MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRAL
VRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAP
IVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL"
gene 3014173..3014658
/locus_tag="Rv2698"
CDS 3014173..3014658
/codon_start=1
/transl_table=11
/locus_tag="Rv2698"
/product="Probable conserved alanine rich transmembrane
protein"
/note="Rv2698, (MTCY05A6.19), len: 161 aa. Probable
conserved ala-rich transmembrane protein, equivalent to
Q49991|ML1027|U1764I possible membrane protein from
Mycobacterium leprae (157 aa), FASTA scores: opt: 886,
E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also
similar to O54132|SC2E9.07c hypothetical 16.5 KDA protein
from Streptomyces coelicolor (154 aa), FASTA scores: opt:
230,E(): 7.1e-08, (35.7% identity in 154 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2698"
/db_xref="EnsemblGenomes-Tr:CCP45496"
/db_xref="GOA:I6X552"
/db_xref="InterPro:IPR021443"
/db_xref="UniProtKB/TrEMBL:I6X552"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45496.1"
/translation="MSGTRLAPHSVRYRERLWVPWWWWPLAFALAALIAFEVNLGVAA
LPDWVPFATLFTVAAGTLLWLGRVEIRVTAGSADGAGVKLWAGPAHLPVAVIARSAEI
PATAKSAALGRQLDPAAYVLHRAWVGPMVLVVLDDPNDPTPYWLVSCRHPERVLSALR
S"
gene complement(3014663..3014965)
/locus_tag="Rv2699c"
CDS complement(3014663..3014965)
/codon_start=1
/transl_table=11
/locus_tag="Rv2699c"
/product="Conserved hypothetical protein"
/note="Rv2699c, (MTCY05A6.20c), len: 100 aa. Conserved
hypothetical protein, very equivalent to
Q49990|ML1026|U1764J hypothetical protein from
Mycobacterium leprae (100 aa), FASTA scores: opt: 632,
E(): 7.7e-36, (96.0% identity in 100 aa overlap). Also
highly similar to O54130|SC2E9.05 hypothetical 11.0 KDA
protein from Streptomyces coelicolor (98 aa), FASTA
scores: opt: 465, E(): 1.1e-24, (71.45% identity in 98 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2699c"
/db_xref="EnsemblGenomes-Tr:CCP45497"
/db_xref="InterPro:IPR025242"
/db_xref="UniProtKB/TrEMBL:I6YA17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45497.1"
/translation="MPTDYDAPRRTETDDVSEDSLEELKARRNEAASAVVDVDESESA
ESFELPGADLSGEELSVRVVPKQADEFTCSSCFLVQHRSRLASEKNGVMICTDCAA"
gene 3015203..3015853
/locus_tag="Rv2700"
CDS 3015203..3015853
/codon_start=1
/transl_table=11
/locus_tag="Rv2700"
/product="Possible conserved secreted alanine rich
protein"
/note="Rv2700, (MTCY05A6.21), len: 216 aa. Possible
secreted ala-rich protein, equivalent to
Q4998|ML1025|U1764H possible secreted protein from
Mycobacterium leprae (216 aa), FASTA scores: opt:
1198,E(): 1.2e-65, (82.4% identity in 216 aa overlap).
Also showing some similarity with Q9AK75|2SCD60.08c
conserved hypothetical protein from Streptomyces
coelicolor (204 aa),FASTA scores: opt: 193, E(): 8.9e-05,
(31.25% identity in 192 aa overlap). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2700"
/db_xref="EnsemblGenomes-Tr:CCP45498"
/db_xref="GOA:I6Y1I5"
/db_xref="InterPro:IPR027381"
/db_xref="UniProtKB/TrEMBL:I6Y1I5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45498.1"
/translation="MVAQITEGTAFDKHGRPFRRRNPRPAIVVVAFLVVVTCVMWTLA
LTRPPDVREAAVCNPPPQPAGSAPTNLGEQVSRTDMTDVAPAKLSDTKVHVLNASGRG
GQAADIAGALQDLGFAQPTAANDPIYAGTRLDCQGQIRFGTAGQATAAALWLVAPCTE
LYHDSRADDSVDLALGTDFTTLAHNDDIDAVLANLRPGATEPSDPALLAKIHANSC"
gene complement(3015863..3016735)
/gene="suhB"
/locus_tag="Rv2701c"
CDS complement(3015863..3016735)
/codon_start=1
/transl_table=11
/gene="suhB"
/locus_tag="Rv2701c"
/product="Inositol-1-monophosphatase SuhB"
/note="Rv2701c, (MTCY05A6.22c), len: 290 aa.
SuhB,inositol-1-monophosphatase. Equivalent to AAK47090
from Mycobacterium tuberculosis strain CDC1551 (277 aa)
but longer 13 aa. Contains PS00630 Inositol
monophosphatase family signatures 1 and 2 (PS00629 and
PS00630). Belongs to the inositol monophosphatase family.
Cofactor: Mg2+. Activity is inhibited by Li+ but not when
Leu81 is mutated (See Nigou et al., 2002). Mg2+ promotes
dimerization; Li+ amplifies this effect but does not
promote dimerization on its own (See Brown et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2701c"
/db_xref="EnsemblGenomes-Tr:CCP45499"
/db_xref="GOA:P9WKI9"
/db_xref="InterPro:IPR000760"
/db_xref="InterPro:IPR020550"
/db_xref="InterPro:IPR020583"
/db_xref="InterPro:IPR033942"
/db_xref="PDB:2Q74"
/db_xref="UniProtKB/Swiss-Prot:P9WKI9"
/inference="protein motif:PROSITE:PS00630"
/inference="protein motif:PROSITE:PS00629"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45499.1"
/translation="MTRPDNEPARLRSVAENLAAEAAAFVRGRRAEVFGISRAGDGDG
AVRAKSSPTDPVTVVDTDTERLLRDRLAQLRPGDPILGEEGGGPADVTATPSDRVTWV
LDPIDGTVNFVYGIPAYAVSIGAQVGGITVAGAVADVAARTVYSAATGLGAHLTDERG
RHVLRCTGVDELSMALLGTGFGYSVRCREKQAELLAHVVPLVRDVRRIGSAALDLCMV
AAGRLDAYYEHGVQVWDCAAGALIAAEAGARVLLSTPRAGGAGLVVVAAAPGIADELL
AALQRFNGLEPIPD"
gene 3016858..3017655
/gene="ppgK"
/locus_tag="Rv2702"
CDS 3016858..3017655
/codon_start=1
/transl_table=11
/gene="ppgK"
/locus_tag="Rv2702"
/product="Polyphosphate glucokinase PpgK
(polyphosphate-glucose phosphotransferase)"
/note="Rv2702, (MTCY05A6.23), len: 265 aa.
PpgK,polyphosphate glucokinase (see citations
below),equivalent, but shorter 60 aa, to
Q49988|PPGK_MYCLE|ML1023|U1764FG polyphosphate glucokinase
from Mycobacterium leprae (324 aa), FASTA scores: opt:
1411, E(): 5.6e-80, (82.8% identity in 262 aa overlap).
Also highly similar (or just similar) to others e.g.
Q9ADE8|PPGK from Streptomyces coelicolor (246 aa), FASTA
scores: opt: 912, E(): 3e-49, (57.3% identity in 239 aa
overlap); Q9AGV8|PPGK from Corynebacterium ammoniagenes
(Brevibacterium ammoniagenes) (277 aa), FASTA scores: opt:
890, E(): 7.5e-48, (57.75% identity in 239 aa overlap);
P40184|GLK_STRCO|SC6E10.20c from Streptomyces coelicolor
(317 aa), FASTA scores: opt: 233, E(): 3.2e-07, (31.3%
identity in 163 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2702"
/db_xref="EnsemblGenomes-Tr:CCP45500"
/db_xref="GOA:P9WIN1"
/db_xref="InterPro:IPR000600"
/db_xref="UniProtKB/Swiss-Prot:P9WIN1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45500.1"
/translation="MTSTGPETSETPGATTQRHGFGIDVGGSGIKGGIVDLDTGQLIG
DRIKLLTPQPATPLAVAKTIAEVVNGFGWRGPLGVTYPGVVTHGVVRTAANVDKSWIG
TNARDTIGAELGGQQVTILNDADAAGLAETRYGAGKNNPGLVVLLTFGTGIGSAVIHN
GTLIPNTEFGHLEVGGKEAEERAASSVKEKNDWTYPKWAKQVIRVLIAIENAIWPDLF
IAGGGISRKADKWVPLLENRTPVVPAALQNTAGIVGAAMASVADTTH"
gene 3017835..3019421
/gene="sigA"
/gene_synonym="mysA"
/gene_synonym="rpoD"
/gene_synonym="rpoV"
/locus_tag="Rv2703"
CDS 3017835..3019421
/codon_start=1
/transl_table=11
/gene="sigA"
/gene_synonym="mysA"
/gene_synonym="rpoD"
/gene_synonym="rpoV"
/locus_tag="Rv2703"
/product="RNA polymerase sigma factor SigA (sigma-A)"
/note="Rv2703, (MTCY05A6.24), len: 528 aa. SigA (formerly
named mysA, and also known as rpoV or rpoD), RNA
polymerase sigma factor (see citations below), equivalent
(but shorter 55 aa) to Q9S5K3|RPOT (alias Q59532) RNA
polymerase sigma factor from Mycobacterium leprae (576
aa), FASTA scores: opt: 2638, E(): 8.6e-115, (80.35%
identity in 535 aa overlap). Also similar to others e.g.
Q59552|MYSA from Mycobacterium smegmatis (466 aa), FASTA
scores: opt: 2259,E(): 2.3e-97, (76.5% identity in 528 aa
overlap); Q45302|SIGA from Corynebacterium glutamicum
(Brevibacterium flavum) (497 aa), FASTA scores: opt: 1972,
E(): 4.3e-84,(67.35% identity in 505 aa overlap);
Q59813|HRDB from Streptomyces aureofaciens (525 aa), FASTA
scores: opt: 1654, E(): 2.1e-69, (67.5% identity in 468 aa
overlap); etc. Contains sigma-70 family signatures 1 and 2
(PS00715 and PS00716). Belongs to the sigma-70 factor
family."
/db_xref="EnsemblGenomes-Gn:Rv2703"
/db_xref="EnsemblGenomes-Tr:CCP45501"
/db_xref="GOA:P9WGI1"
/db_xref="InterPro:IPR000943"
/db_xref="InterPro:IPR007624"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR007630"
/db_xref="InterPro:IPR009042"
/db_xref="InterPro:IPR012760"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR028630"
/db_xref="InterPro:IPR036388"
/db_xref="PDB:4X8K"
/db_xref="PDB:5UH5"
/db_xref="PDB:5UH6"
/db_xref="PDB:5UH8"
/db_xref="PDB:5UH9"
/db_xref="PDB:5UHA"
/db_xref="PDB:5UHB"
/db_xref="PDB:5UHC"
/db_xref="PDB:5UHD"
/db_xref="PDB:5UHE"
/db_xref="PDB:5UHF"
/db_xref="PDB:5UHG"
/db_xref="PDB:6BZO"
/db_xref="PDB:6C04"
/db_xref="PDB:6C05"
/db_xref="PDB:6C06"
/db_xref="PDB:6EDT"
/db_xref="PDB:6EE8"
/db_xref="PDB:6EEC"
/db_xref="PDB:6FBV"
/db_xref="PDB:6M7J"
/db_xref="UniProtKB/Swiss-Prot:P9WGI1"
/inference="protein motif:PROSITE:PS00715"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45501.1"
/translation="MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGS
PPAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPK
DAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDL
DSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKD
AELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAA
QRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEK
FDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGR
EPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDA
VSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIES
KTMSKLRHPSRSQVLRDYLD"
gene 3019458..3019886
/locus_tag="Rv2704"
CDS 3019458..3019886
/codon_start=1
/transl_table=11
/locus_tag="Rv2704"
/product="Conserved protein"
/note="Rv2704, (MTCY05A6.25), len: 142 aa. Conserved
protein, highly similar (but shorter 25 aa) to
Q9RYB7|DR0033 conserved hypothetical protein from
Deinococcus radiodurans (157 aa), FASTA scores: opt:
381,E(): 1.5e-17, (54.85% identity in 124 aa overlap); and
highly similar to various proteins e.g. CAC47758|SMC03796
conserved hypothetical protein from Rhizobium meliloti
(Sinorhizobium meliloti) (126 aa), FASTA scores: opt:
302,E(): 1.4e-12, (46.6% identity in 126 aa overlap);
Q98E55|MLL4402 from Rhizobium loti (Mesorhizobium loti)
(130 aa), FASTA scores: opt: 252, E(): 2.1e-09, (40.15%
identity in 127 aa overlap); Q9K3V5|SCD10.21 putative
acetyltransferase from Streptomyces coelicolor (291
aa),FASTA scores: opt: 247, E(): 8.7e-09, (41.3% identity
in 138 aa overlap) (homology only in N-terminal region);
etc. Belongs to the YJGF/YER057C/UK114 protein family."
/db_xref="EnsemblGenomes-Gn:Rv2704"
/db_xref="EnsemblGenomes-Tr:CCP45502"
/db_xref="InterPro:IPR006175"
/db_xref="InterPro:IPR035959"
/db_xref="UniProtKB/TrEMBL:I6YA21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45502.1"
/translation="MSASRTMVSSGSEFESAVGYSRAVRIGPLVVVAGTTGSGDDIAA
QTRDALRRIEIALGQAGATLADVVRTRIYVTDISRWREVGEVHAQAFGKIRPVTSMVE
VTALIAPGLLVEIEADAYVGSAVADRNSGAGPKDPSPAGG"
gene complement(3019814..3020203)
/locus_tag="Rv2705c"
CDS complement(3019814..3020203)
/codon_start=1
/transl_table=11
/locus_tag="Rv2705c"
/product="Conserved hypothetical protein"
/note="Rv2705c, (MTCY05A6.26c), len: 129 aa (unlikely
ORF). Conserved hypothetical protein, similar to others
e.g. Q9RXR5|DR0242 conserved hypothetical protein from
Deinococcus radiodurans (112 aa), FASTA scores: opt:
259,E(): 9.4e-10, (40.5% identity in 116 aa overlap);
CAC45122|SMC02246 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) (115 aa),
FASTA scores: opt: 208, E(): 1.6e-06, (38.3% identity in
107 aa overlap); Q98B88|MLL5682 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (116 aa), FASTA
scores: opt: 173, E(): 0.00026, (34.95% identity in 103 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2705c"
/db_xref="EnsemblGenomes-Tr:CCP45503"
/db_xref="InterPro:IPR009297"
/db_xref="UniProtKB/TrEMBL:O07206"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45503.1"
/translation="MRMTPDPAMLVHLCGVQEWSHARERGGIYPESDKTGYIHLSTLE
QVHLPANRLYRGRADLVLLYIDPAALDSPVRWEPGVPTDPRSMLFPHLYGPLPVRAVI
GAAAYPPAGDGSFGPAPEFRSATADPT"
gene complement(3020200..3020457)
/locus_tag="Rv2706c"
CDS complement(3020200..3020457)
/codon_start=1
/transl_table=11
/locus_tag="Rv2706c"
/product="Hypothetical protein"
/note="Rv2706c, (MTCY05A6.27c), len: 85 aa (unlikely ORF).
Hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2706c"
/db_xref="EnsemblGenomes-Tr:CCP45504"
/db_xref="UniProtKB/TrEMBL:O07207"
/protein_id="CCP45504.1"
/translation="MLVGVMLAEKKLGSGGQLGAHPSCSATAVAAVCSSQLRTGQSCV
HGSPFSGIFTFSDVRGSRRVPRPLSGVSFLTTFAPANRAGW"
gene 3020573..3021547
/locus_tag="Rv2707"
CDS 3020573..3021547
/codon_start=1
/transl_table=11
/locus_tag="Rv2707"
/product="Probable conserved transmembrane alanine and
leucine rich protein"
/note="Rv2707, (MTCY05A6.28), len: 324 aa. Probable
conserved transmembrane ala-, leu-rich protein, equivalent
to Q49985|ML1017|U1764D possible conserved integral
membrane protein from Mycobacterium leprae (330 aa), FASTA
scores: opt: 1617, E(): 2.5e-91, (75.4% identity in 325 aa
overlap). Also similar to other membrane proteins e.g.
Q9ADF6|SCBAC1A6.31 putative integral membrane protein from
Streptomyces coelicolor (344 aa), FASTA scores: opt:
593,E(): 5.9e-29, (36.2% identity in 268 aa overlap);
Q99SZ8|SA1699 hypothetical protein (similar to
transporter) from Staphylococcus aureus subsp. aureus N315
(405 aa),FASTA scores: opt: 318, E(): 3.7e-12, (27.9%
identity in 265 aa overlap); O34437|YFKH hypothetical
protein (similar to transporter) from Bacillus subtilis
(275 aa), FASTA scores: opt: 309, E(): 9.7e-12, (29.3%
identity in 263 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2707"
/db_xref="EnsemblGenomes-Tr:CCP45505"
/db_xref="GOA:I6YE67"
/db_xref="InterPro:IPR017039"
/db_xref="UniProtKB/TrEMBL:I6YE67"
/protein_id="CCP45505.1"
/translation="MSDQVPKPHRHHIWRITRRTLSKSWDDSIFSESAQAAFWSALSL
PPLLLGMLGSLAYVAPLFGPDTLPAIEKSALSTAHSFFSPSVVNEIIEPTIGDITNNA
RGEVASLGFLISLWAGSSAISAFVDAVVEAHDQTPLRHPVRQRFFALFLYVVMLVFLV
ATAPVMVVGPRKVSEHIPESLANLLRYGYYPALILGLTVGVILLYRVALPVPLPTHRL
VLGAVLAIAVFLIATLGLRVYLAWITRTGYTYGALATPIAFLLFAFFGGFAIMLGAEL
NAAVQEEWPAPATHAHRLGNWLKARIGVGTTTYSSTAQHSAVAAEPPS"
gene complement(3021548..3021796)
/locus_tag="Rv2708c"
CDS complement(3021548..3021796)
/codon_start=1
/transl_table=11
/locus_tag="Rv2708c"
/product="Conserved hypothetical protein"
/note="Rv2708c, (MTCY05A6.29), len: 82 aa. Conserved
hypothetical protein, equivalent (but shorter 25 aa) to
Q49984|ML1016|U1764C hypothetical protein from
Mycobacterium leprae (107 aa), FASTA scores: opt: 492,
E(): 7.3e-27, (87.8% identity in 82 aa overlap). Also
highly similar to Q9L1U7|SCE59.06c hypothetical 10.4 KDA
protein from Streptomyces coelicolor (97 aa), FASTA
scores: opt: 200, E(): 4.4e-07, (51.6% identity in 62 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2708c"
/db_xref="EnsemblGenomes-Tr:CCP45506"
/db_xref="InterPro:IPR021400"
/db_xref="UniProtKB/TrEMBL:I6X562"
/protein_id="CCP45506.1"
/translation="MSGMQTQTIERTDADERVDDGTGSDTPKYFHYVKKDKIAESAVM
GSHVVALCGEVFPVTRAPKPGSPVCPDCKRIYDTLKKG"
gene 3021839..3022285
/locus_tag="Rv2709"
CDS 3021839..3022285
/codon_start=1
/transl_table=11
/locus_tag="Rv2709"
/product="Probable conserved transmembrane protein"
/note="Rv2709, (MTCY05A6.30), len: 148 aa. Probable
conserved transmembrane protein, equivalent to
Q9CCB4|ML1015 (alias Q49983|U1764B but extended in
N-terminus) possible conserved membrane protein from
Mycobacterium leprae (139 aa), FASTA scores: opt: 578,
E(): 5.5e-31, (70.75% identity in 123 aa overlap). Shows
also similarity with Q9RJ48|SCI8.05 putative integral
membrane protein from Streptomyces coelicolor (159 aa),
FASTA scores: opt: 119, E(): 0.57, (31.95% identity in 119
aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2709"
/db_xref="EnsemblGenomes-Tr:CCP45507"
/db_xref="GOA:I6YA25"
/db_xref="InterPro:IPR021449"
/db_xref="UniProtKB/TrEMBL:I6YA25"
/protein_id="CCP45507.1"
/translation="MWDSRVMKHGLRLGFNGQFDDFDDFDDKGRPVLITAAAPSYEVE
HRTRVRKYLTLMAFRVPALILAAIAYGAWHNGLISLLIVAASVPLPWMAVLIANDRPP
RRADEPRRFDVARRRIPLFPTAERPALEPRRQPAERSAPRGFADHG"
gene 3022461..3023432
/gene="sigB"
/gene_synonym="mysB"
/locus_tag="Rv2710"
CDS 3022461..3023432
/codon_start=1
/transl_table=11
/gene="sigB"
/gene_synonym="mysB"
/locus_tag="Rv2710"
/product="RNA polymerase sigma factor SigB"
/note="Rv2710, (MTCY05A6.31), len: 323 aa. SigB (formerly
known as mysB), RNA polymerase sigma factor (see citations
below), equivalent to Q59531|ML1014 RNA polymerase sigma
factor from Mycobacterium leprae (319 aa), FASTA scores:
opt: 1935, E(): 1.9e-109, (96.2% identity in 316 aa
overlap). Also highly similar to others e.g. Q59553|MYSB
from Mycobacterium smegmatis (319 aa), FASTA scores: opt:
1874, E(): 9.1e-106, (92.4% identity in 316 aa overlap);
Q9ANT6|SIGB from Brevibacterium flavum (331 aa), FASTA
scores: opt: 1525, E(): 9.9e-85, (78.9% identity in 303 aa
overlap); Q60158|RPOV from Mycobacterium bovis (528
aa),FASTA scores: opt: 1246, E(): 9.3e-68, (62.85%
identity in 315 aa overlap); etc. Contains sigma-70
factors family signatures 1 and 2 (PS00715 and PS00716).
And contains possible helix-turn-helix motif at aa 282-303
(Score 1887,+5.61 SD). Belongs to the sigma-70 factor
family."
/db_xref="EnsemblGenomes-Gn:Rv2710"
/db_xref="EnsemblGenomes-Tr:CCP45508"
/db_xref="GOA:P9WGI5"
/db_xref="InterPro:IPR000943"
/db_xref="InterPro:IPR007624"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR007630"
/db_xref="InterPro:IPR009042"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WGI5"
/inference="protein motif:PROSITE:PS00715"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45508.1"
/translation="MADAPTRATTSRVDSDLDAQSPAADLVRVYLNGIGKTALLNAAG
EVELAKRIEAGLYAEHLLETRKRLGENRKRDLAAVVRDGEAARRHLLEANLRLVVSLA
KRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRT
IRLPVHLVEQVNKLARIKREMHQHLGREATDEELAAESGIPIDKINDLLEHSRDPVSL
DMPVGSEEEAPLGDFIEDAEAMSAENAVIAELLHTDIRSVLATLDEREHQVIRLRFGL
DDGQPRTLDQIGKLFGLSRERVRQIERDVMSKLRHGERADRLRSYAS"
gene 3023565..3024257
/gene="ideR"
/gene_synonym="dtxR"
/locus_tag="Rv2711"
CDS 3023565..3024257
/codon_start=1
/transl_table=11
/gene="ideR"
/gene_synonym="dtxR"
/locus_tag="Rv2711"
/product="Iron-dependent repressor and activator IdeR"
/note="Rv2711, (MTCY05A6.32), len: 230 aa. IdeR (formerly
known as dtxR), iron dependent repressor and activator
(see citations below), equivalent to Q9CCB5|ML1013 iron
dependent repressor from Mycobacterium leprae (230
aa),FASTA scores: opt: 1365, E(): 3.8e-77, (90.0% identity
in 230 aa overlap). Also highly similar to others e.g.
Q50379|DTXR from Mycobacterium smegmatis (233 aa), FASTA
scores: opt: 1291, E(): 1.4e-72, (86.1% identity in 230 aa
overlap); Q9F7T3|IDER from Corynebacterium equii
(Rhodococcus equi) (230 aa), FASTA scores: opt: 1130, E():
1.2e-62, (74.8% identity in 230 aa overlap);
P33120|DTXR_CORDI from Corynebacterium diphtheriae (226
aa), FASTA scores: opt: 803, E(): 1.6e-42, (57.85%
identity in 230 aa overlap); etc. Belongs to the fur
family."
/db_xref="EnsemblGenomes-Gn:Rv2711"
/db_xref="EnsemblGenomes-Tr:CCP45509"
/db_xref="GOA:P9WMH1"
/db_xref="InterPro:IPR001367"
/db_xref="InterPro:IPR007167"
/db_xref="InterPro:IPR008988"
/db_xref="InterPro:IPR022687"
/db_xref="InterPro:IPR022689"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR036421"
/db_xref="InterPro:IPR038157"
/db_xref="PDB:1B1B"
/db_xref="PDB:1FX7"
/db_xref="PDB:1U8R"
/db_xref="PDB:2ISY"
/db_xref="PDB:2ISZ"
/db_xref="PDB:2IT0"
/db_xref="UniProtKB/Swiss-Prot:P9WMH1"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45509.1"
/translation="MNELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQT
VSRMERDGLLRVAGDRHLELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAEAC
RWEHVMSEDVERRLVKVLNNPTTSPFGNPIPGLVELGVGPEPGADDANLVRLTELPAG
SPVAVVVRQLTEHVQGDIDLITRLKDAGVVPNARVTVETTPGGGVTIVIPGHENVTLP
HEMAHAVKVEKV"
gene complement(3024270..3025328)
/locus_tag="Rv2712c"
CDS complement(3024270..3025328)
/codon_start=1
/transl_table=11
/locus_tag="Rv2712c"
/product="Hypothetical protein"
/note="Rv2712c, (MTCY05A6.33c), len: 352 aa. Hypothetical
unknown ala-, leu-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv2712c"
/db_xref="EnsemblGenomes-Tr:CCP45510"
/db_xref="InterPro:IPR025447"
/db_xref="UniProtKB/TrEMBL:I6YE70"
/protein_id="CCP45510.1"
/translation="MTKYRGQFELNRPATLIAALPAILGFVPEKSLVLVSLAAGELGS
VMRADLCDELADRVGHLAELVAAANPAAAIAVIVDANGAQCPRCNEEYRQLCAALAAA
LSQRDIVLWAAHVVDRVAAGGRWHCVDGCGCSGVIDDPSASPLAMAAVLDGRQLYPRR
SDLQAVIAVDDPVRSAELAVALGHQAADREIAHRADSVGCSRQDVENALAAAARVADG
QSLSDTELARLGCALGDARVRDMLYALAVGENAGAAESLWALLARVLPEPWRVEALVL
LAFSAYARGDGPLAGVSLQAALCCEPGHRMAGMLDTALQSGLRPEHIRDIAVTGYQRA
EQLGIRLPPRRAFGQRAG"
gene 3025441..3026847
/gene="sthA"
/locus_tag="Rv2713"
CDS 3025441..3026847
/codon_start=1
/transl_table=11
/gene="sthA"
/locus_tag="Rv2713"
/product="Probable soluble pyridine nucleotide
transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase
[B-specific]) (nicotinamide nucleotide transhydrogenase)"
/note="Rv2713, (MT2786, MTCY05A6.34), len: 468 aa.
Probable sthA, soluble pyridine nucleotide
transhydrogenase, highly similar to others e.g.
Q983E2|MLR8366 from Rhizobium loti (Mesorhizobium loti)
(481 aa), FASTA scores: opt: 1447,E(): 4.1e-78, (49.55%
identity in 460 aa overlap);
P27306|STHA_ECOLI|STH|UDHA|B3962 from Escherichia coli
strain K12 (465 aa), FASTA scores: opt: 1267, E():
1.7e-67,(43.05% identity in 462 aa overlap);
O05139|STHA_PSEFL|STH from Pseudomonas fluorescens (463
aa), FASTA scores: opt: 1257, E(): 6.6e-67, (43.8%
identity in 461 aa overlap); etc. Also highly similar to
CAC46308|SMC00300 putative oxidoreductase protein from
Rhizobium meliloti (Sinorhizobium meliloti) (467 aa),
FASTA scores: opt: 1466,E(): 3e-79, (49.55% identity in
462 aa overlap). Shows some similarity to MTCY359.04, E():
3.1e-08; MTCY210.05, E(): 3.4e-08. Contains
ATP/GTP-binding site motif A (P-loop; PS00017). Belongs to
the pyridine nucleotide-disulfide oxidoreductases class-I.
Cofactor: FAD (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv2713"
/db_xref="EnsemblGenomes-Tr:CCP45511"
/db_xref="GOA:P9WHH5"
/db_xref="InterPro:IPR001100"
/db_xref="InterPro:IPR004099"
/db_xref="InterPro:IPR016156"
/db_xref="InterPro:IPR022962"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WHH5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45511.1"
/translation="MREYDIVVIGSGPGGQKAAIASAKLGKSVAIVERGRMLGGVCVN
TGTIPSKTLREAVLYLTGMNQRELYGASYRVKDRITPADLLARTQHVIGKEVDVVRNQ
LMRNRVDLIVGHGRFIDPHTILVEDQARREKTTVTGDYIIIATGTRPARPSGVEFDEE
RVLDSDGILDLKSLPSSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDNMLDFCDPEV
VEALKFHLRDLAVTFRFGEEVTAVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDH
LDLHNAGLEVQGRGRIFVDDRFQTKVDHIYAVGDVIGFPALAATSMEQGRLAAYHAFG
EPTDGITELQPIGIYSIPEVSYVGATEVELTKSSIPYEVGVARYRELARGQIAGDSYG
MLKLLVSTEDLKLLGVHIFGTSATEMVHIGQAVMGCGGSVEYLVDAVFNYPTFSEAYK
NAALDVMNKMRALNQFRR"
gene 3027065..3028039
/locus_tag="Rv2714"
CDS 3027065..3028039
/codon_start=1
/transl_table=11
/locus_tag="Rv2714"
/product="Conserved alanine and leucine rich protein"
/note="Rv2714, (MTCY05A6.35), len: 324 aa. Conserved
ala-,leu-rich protein, equivalent to
Q49847|ML1009|B2235_F1_6 hypothetical protein from
Mycobacterium leprae (326 aa),FASTA scores: opt: 1881,
E(): 5.8e-107, (89.7% identity in 320 aa overlap); and
similar to Q49797|MLCB2533.03c|B2126_F1_36 hypothetical
protein from Mycobacterium leprae (317 aa), FASTA scores:
opt: 376, E(): 1.2e-15, (30.1% identity in 279 aa
overlap); and Q9CC38|ML1306 hypothetical protein from
Mycobacterium leprae (274 aa), FASTA scores: opt: 367,
E(): 3.6e-15,(29.8% identity in 275 aa overlap). Also
highly similar to Q9S2K6|SC7H2.11c hypothetical 34.2 KDA
protein from Streptomyces coelicolor (312 aa), FASTA
scores: opt: 770,E(): 1.4e-39, (40.9% identity in 286 aa
overlap); and similar to Q9ADA5|SCI52.04 conserved
hypothetical protein from Streptomyces coelicolor (333
aa), FASTA scores: opt: 386, E(): 3e-16, (29.05% identity
in 296 aa overlap). Also similar to
O33260|Rv2125|MTCY261.21 hypothetical protein from
Mycobacterium tuberculosis (292 aa), FASTA scores: opt:
387, E(): 2.3e-16, (29.45% identity in 292 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2714"
/db_xref="EnsemblGenomes-Tr:CCP45512"
/db_xref="InterPro:IPR008492"
/db_xref="InterPro:IPR019151"
/db_xref="InterPro:IPR038389"
/db_xref="UniProtKB/TrEMBL:I6YA29"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45512.1"
/translation="MARDQGADEAREYEPGQPGMYELEFPAPQLSSSDGRGPVLVHAL
EGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPE
LSLYALRDSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHT
RPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLT
QTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALER
QYDAFIDAQENRSLLTRDEDLPSGDELGAEFERFLAQQAEKKSDDDPT"
gene 3028098..3029123
/locus_tag="Rv2715"
CDS 3028098..3029123
/codon_start=1
/transl_table=11
/locus_tag="Rv2715"
/product="Possible hydrolase"
/note="Rv2715, (MTCY05A6.36), len: 341 aa. Possible
hydrolase, showing some similarity with other hydrolases
e.g. Q9I5B0|PA0829 probable hydrolase from Pseudomonas
aeruginosa (313 aa), FASTA scores: opt: 336, E():
9.9e-14,(28.05% identity in 289 aa overlap); BAB55888
hydrolase (fragment) from Terrabacter sp. DBF63 (319 aa),
FASTA scores: opt: 326, E(): 4.2e-13, (27.95% identity in
290 aa overlap); O52866|CEH|eh soluble epoxide hydrolase
from Corynebacterium SP (285 aa), FASTA scores: opt: 325,
E(): 4.4e-13, (29.95% identity in 284 aa overlap); etc.
Also shows some similarity to P96811|EPHF|Rv0134|MTCI5.08
hypothetical 33.8 KDA protein from Mycobacterium
tuberculosis (300 aa), FASTA scores: E(): 1.8e-10, (27.7%
identity in 271 aa overlap). Contains lipases, serine
active site motif (PS00120)."
/db_xref="EnsemblGenomes-Gn:Rv2715"
/db_xref="EnsemblGenomes-Tr:CCP45513"
/db_xref="GOA:P9WNH3"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WNH3"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45513.1"
/translation="MTERKRNLRPVRDVAPPTLQFRTVHGYRRAFRIAGSGPAILLIH
GIGDNSTTWNGVHAKLAQRFTVIAPDLLGHGQSDKPRADYSVAAYANGMRDLLSVLDI
ERVTIVGHSLGGGVAMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMA
LLRLPLVLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRTLRAVV
DWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGSQLEIFEGSGHF
PFHDDPARFIDIVERFMDTTEPAEYDQAALRALLRRGGGEATVTGSADTRVAVLNAIG
SNERSAT"
gene 3029172..3029858
/locus_tag="Rv2716"
CDS 3029172..3029858
/codon_start=1
/transl_table=11
/locus_tag="Rv2716"
/product="Conserved protein"
/note="Rv2716, (MTCY05A6.37), len: 228 aa. Conserved
protein, similar to other proteins e.g. Q9RKR0|SCC75A.14
hypothetical 23.3 KDA protein from Streptomyces coelicolor
(214 aa), FASTA scores: opt: 447, E(): 4e-22, (44.1%
identity in 220 aa overlap); Q9HHG6|PHZF|VNG6408G
phenazine biosynthetic protein from Halobacterium sp.
strain NRC-1 (299 aa), FASTA scores: opt: 201, E():
6.1e-06, (30.4% identity in 148 aa overlap) (similarity
only at N-terminus); P73125|SLR1019 hypothetical 34.1 KDA
protein from Synechocystis sp. strain PCC 6803 (314 aa),
FASTA scores: opt: 196, E(): 1.4e-05, (28.5% identity in
298 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2716"
/db_xref="EnsemblGenomes-Tr:CCP45514"
/db_xref="GOA:P9WL43"
/db_xref="InterPro:IPR003719"
/db_xref="UniProtKB/Swiss-Prot:P9WL43"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45514.1"
/translation="MAIEVSVLRVFTDSDGNFGNPLGVINASKVEHRDRQQLAAQSGY
SETIFVDLPSPGSTTAHATIHTPRTEIPFAGHPTVGASWWLRERGTPINTLQVPAGIV
QVSYHGDLTAISARSEWAPEFAIHDLDSLDALAAADPADFPDDIAHYLWTWTDRSAGS
LRARMFAANLGVTEDEATGAAAIRITDYLSRDLTITQGKGSLIHTTWSPEGWVRVAGR
VVSDGVAQLD"
gene complement(3029867..3030361)
/locus_tag="Rv2717c"
CDS complement(3029867..3030361)
/codon_start=1
/transl_table=11
/locus_tag="Rv2717c"
/product="Conserved protein"
/note="Rv2717c, (MTCY05A6.38c), len: 164 aa. Conserved
protein, equivalent to Q9CCB8|ML1006 (alias Q49838 but
shortened N-terminus) hypothetical protein from
Mycobacterium leprae (161 aa), FASTA scores: opt: 797,
E(): 2.3e-46, (73.8% identity in 164 aa overlap). Also
highly similar to other eukaryotic proteins e.g.
O64527|YUP8H12R.14 hypothetical protein from Arabidopsis
thaliana (Mouse-ear cress) (166 aa), FASTA scores: opt:
393, E(): 2.3e-19, (42.4% identity in 158 aa overlap);
Q9Y325 CGI-36 protein from Homo sapiens (Human) (165
aa),FASTA scores: opt: 294, E(): 9.5e-13, (33.95% identity
in 159 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2717c"
/db_xref="EnsemblGenomes-Tr:CCP45515"
/db_xref="GOA:P9WFG7"
/db_xref="InterPro:IPR012674"
/db_xref="InterPro:IPR014878"
/db_xref="InterPro:IPR022939"
/db_xref="PDB:2FR2"
/db_xref="UniProtKB/Swiss-Prot:P9WFG7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45515.1"
/translation="MTRDLAPALQALSPLLGSWAGRGAGKYPTIRPFEYLEEVVFAHV
GKPFLTYTQQTRAVADGKPLHSETGYLRVCRPGCVELVLAHPSGITEIEVGTYSVTGD
VIELELSTRADGSIGLAPTAKEVTALDRSYRIDGDELSYSLQMRAVGQPLQDHLAAVL
HRQR"
gene complement(3030413..3030877)
/gene="nrdR"
/locus_tag="Rv2718c"
CDS complement(3030413..3030877)
/codon_start=1
/transl_table=11
/gene="nrdR"
/locus_tag="Rv2718c"
/product="Probable transcriptional regulatory protein
NrdR"
/note="Rv2718c, (MTCY05A6.39c), len: 154 aa. Probable
nrdR,transcriptional regulatory protein, equivalent to
Q49844|ML1005|U2235A|B2235_C2_209 hypothetical 17.3 KDA
protein from Mycobacterium leprae (154 aa), FASTA scores:
opt: 937, E(): 1.5e-52, (92.7% identity in 151 aa
overlap). Highly similar to O86848|NRDR_STRCL putative
regulatory protein from Streptomyces clavuligerus (172
aa), FASTA scores: opt: 750, E(): 1.1e-40, (73.65%
identity in 148 aa overlap); O69980|SC4H2.25 hypothetical
protein from Streptomyces coelicolor (182 aa), FASTA
scores: opt: 725,E(): 4.6e-39, (73.1% identity in 145 aa
overlap); Q9KPU0|VC2272 hypothetical protein from Vibrio
cholerae (156 aa), FASTA scores: opt: 462, E(): 1.8e-22,
(47.3% identity in 148 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2718c"
/db_xref="EnsemblGenomes-Tr:CCP45516"
/db_xref="GOA:P9WIZ1"
/db_xref="InterPro:IPR003796"
/db_xref="InterPro:IPR005144"
/db_xref="UniProtKB/Swiss-Prot:P9WIZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45516.1"
/translation="MHCPFCRHPDSRVIDSRETDEGQAIRRRRSCPECGRRFTTVETA
VLAVVKRSGVTEPFSREKVISGVRRACQGRQVDDDALNLLAQQVEDSVRAAGSPEIPS
HDVGLAILGPLRELDEVAYLRFASVYRSFSSADDFAREIEALRAHRNLSAHS"
gene complement(3031040..3031537)
/locus_tag="Rv2719c"
CDS complement(3031040..3031537)
/codon_start=1
/transl_table=11
/locus_tag="Rv2719c"
/product="Possible conserved membrane protein"
/note="Rv2719c, (MTCY05A6.40c), len: 165 aa. Possible
conserved membrane protein, equivalent to
Q49846|ML1004|B2235_C3_243 possible conserved membrane
protein from Mycobacterium leprae (164 aa), FASTA scores:
opt: 486, E(): 4e-21, (55.2% identity in 163 aa overlap).
A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2719c"
/db_xref="EnsemblGenomes-Tr:CCP45517"
/db_xref="GOA:I6YA32"
/db_xref="InterPro:IPR018392"
/db_xref="UniProtKB/TrEMBL:I6YA32"
/protein_id="CCP45517.1"
/translation="MTPVRPPHTPDPLNLRGPLDGPRWRRAEPAQSRRPGRSRPGGAP
LRYHRTGVGMSRTGHGSRPVPPATTVGLALLAAAITLWLGLVAQFGQMITGGSADGSA
DSTGRVPDRLAVVRVETGESLYDVAVRVAPNAPTRQVADRIRELNGLQTPALAVGQTL
IAPVG"
gene 3031788..3032498
/gene="lexA"
/locus_tag="Rv2720"
CDS 3031788..3032498
/codon_start=1
/transl_table=11
/gene="lexA"
/locus_tag="Rv2720"
/product="Repressor LexA"
/note="Rv2720, (MTCY05A6.41), len: 236 aa. LexA repressor
(see citations below), equivalent to
Q49848|LEXA_MYCLE|ML1003|B2235_F2_55 LEXA repressor from
Mycobacterium leprae (217 aa), FASTA scores: opt:
1255,E(): 7.1e-70, (89.8% identity in 216 aa overlap).
Also highly similar to others e.g.
O69979|LEXA_STRCO|SC4H2.24c from Streptomyces coelicolor
(234 aa), FASTA scores: opt: 1034, E(): 2.6e-56, (70.5%
identity in 217 aa overlap); O86847|LEXA_STRCL from
Streptomyces clavuligerus (239 aa),FASTA scores: opt:
1021, E(): 1.6e-55, (69.1% identity in 217 aa overlap);
Q9KAD3|LEXA_BACHD from Bacillus halodurans (207 aa), FASTA
scores: opt: 645, E(): 1.5e-32, (47.9% identity in 213 aa
overlap); etc. Belongs to peptidase family S24; also known
as the UMUD/LEXA family. Start changed since first
submission (+19 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2720"
/db_xref="EnsemblGenomes-Tr:CCP45518"
/db_xref="GOA:P9WHR7"
/db_xref="InterPro:IPR006197"
/db_xref="InterPro:IPR006199"
/db_xref="InterPro:IPR006200"
/db_xref="InterPro:IPR015927"
/db_xref="InterPro:IPR036286"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR039418"
/db_xref="PDB:6A2Q"
/db_xref="PDB:6A2R"
/db_xref="PDB:6A2S"
/db_xref="PDB:6A2T"
/db_xref="UniProtKB/Swiss-Prot:P9WHR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45518.1"
/translation="MNDSNDTSVAGGAAGADSRVLSADSALTERQRTILDVIRASVTS
RGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVNVRGADDAALPPV
TEVAGSDALPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGTLFLLKVIGDS
MVEAAICDGDWVVVRQQNVADNGDIVAAMIDGEATVKTFKRAGGQVWLMPHNPAFDPI
PGNDATVLGKVVTVIRKV"
gene complement(3032520..3034619)
/locus_tag="Rv2721c"
CDS complement(3032520..3034619)
/codon_start=1
/transl_table=11
/locus_tag="Rv2721c"
/product="Possible conserved transmembrane alanine and
glycine rich protein"
/note="Rv2721c, (MTCY05A6.42c, MTCY154.01c), len: 699 aa.
Possible conserved transmembrane ala-, gly-rich
protein,equivalent to Q49837|ML1002|U2235I possible
conserved membrane protein from Mycobacterium leprae (687
aa), FASTA scores: opt: 2703, E(): 6.6e-135, (60.3%
identity in 713 aa overlap). Shows some similaity to
Q01377|CSP1 PS1 protein precursor (secreted protein) from
Corynebacterium glutamicum (Brevibacterium flavum) (657
aa), FASTA scores: opt: 276, E(): 3.8e-07, (29.4% identity
in 272 aa overlap); and Q9KIJ0 Rv2721c-like protein from
Mycobacterium paratuberculosis (246 aa), FASTA scores:
opt: 178, E(): 0.025, (37.5% identity in 120 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2721c"
/db_xref="EnsemblGenomes-Tr:CCP45519"
/db_xref="GOA:I6XF52"
/db_xref="InterPro:IPR013207"
/db_xref="UniProtKB/TrEMBL:I6XF52"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45519.1"
/translation="MNGQRGQLSTLIGRTLLGLAATAVTAVLLAPTVAASPMGDAEDA
MMAAWEKAGGDTSTLGVRKGDVYPIGDGFALDFAGGKMFFTPATGAKYLYGPLLDKYE
SLGGAADSDLGFPTINEVPGLAGPDSRVSTFSAADNPVIFWTPEHGAFVVRGALNAAW
DKLGSSGGVLGAPVGDETYDGEVTAQKFSGGEVSWNRATKEFTTVPAVLAEQLKGLQV
AIDPSAAINMAWRAAGGAAGPLGAKKGGQYPIGGDGIAQDFVGGKVFFSPATGANAVE
GEILAKYESLGGPVSSDLGFPIANETDGGFGPSSRIVRFSAADKPVIFWTPDHGAFVV
RGAMVAAWDKLRGPNGKLGAPVGDQTVDGDVVSQKFTGGMISWNRAKNTFTTDPANLA
PLLSGLQVSGQNQPSTSAMPPPGKKFTWHWWWLGAAALGVLLVVMVALVVFGLRRRRR
GYDAAAYDDDRAGDVEYGTAADGDWPPDEDFGSEHFGFGDQFPPEPVAPDAGSTPRVS
WPRGAGAAVGDAEHLPGEEGYGSDLLSGPSNVGVEEEDTDAVDTTPTPVVSQADLSEV
GPDLIVPERVVPETFVPQAFVPEAVAPEAVPPDVHAADLADTGLPAAAVSAAEDRGGR
HAAAEPPEPPSAGVRPAIHLPLEDPYQMPNGYPVKASVSFGLYYPPGSALYHDTLAEL
WFASEEVAQVNGFIRAD"
gene 3034635..3034883
/locus_tag="Rv2722"
CDS 3034635..3034883
/codon_start=1
/transl_table=11
/locus_tag="Rv2722"
/product="Conserved hypothetical protein"
/note="Rv2722, (MTCY154.02), len: 82 aa. Conserved
hypothetical protein, similar to Q9CCB9|ML1001
hypothetical protein from Mycobacterium leprae (91 aa),
FASTA scores: opt: 154, E(): 0.00053, (37.5% identity in
88 aa overlap). Equivalent to AAK47111 from Mycobacterium
tuberculosis strain CDC1551 (94 aa) but shorter 12 aa. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2722"
/db_xref="EnsemblGenomes-Tr:CCP45520"
/db_xref="UniProtKB/TrEMBL:O33227"
/protein_id="CCP45520.1"
/translation="MPCLARQPVDLPPWAGPRCGPYCPRARITLLQRTTIAKSNRKYY
ENGYPADVKLMPGHAAVVSNRAAARAGFALPCRKRQPD"
gene 3034909..3036102
/locus_tag="Rv2723"
CDS 3034909..3036102
/codon_start=1
/transl_table=11
/locus_tag="Rv2723"
/product="Probable conserved integral membrane protein"
/note="Rv2723, (MTCY154.03), len: 397 aa. Probable
conserved integral membrane protein, highly similar to
others e.g. Q9Z503|SCC54.23c putative integral membrane
export protein from Streptomyces coelicolor (333 aa),
FASTA scores: opt: 883, E(): 2.4e-48, (46.4% identity in
332 aa overlap); Q9RD18|SCM1.25c putative integral
membrane protein from Streptomyces coelicolor (316 aa),
FASTA scores: opt: 865, E(): 3.1e-47, (47.55% identity in
324 aa overlap); P96554|Y319_MYXXA integral membrane
protein (probable) from Myxococcus xanthus (319 aa), FASTA
scores: opt: 626, E(): 3.4e-32, (34.65% identity in 323 aa
overlap); P42601|YGJT_ECOLI|B3088 from Escherichia coli
strain K12 integral membrane protein (probable) (321
aa),FASTA scores: opt: 541, E(): 7.7e-27, (35.1% identity
in 279 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2723"
/db_xref="EnsemblGenomes-Tr:CCP45521"
/db_xref="GOA:P9WG93"
/db_xref="InterPro:IPR005496"
/db_xref="InterPro:IPR022369"
/db_xref="UniProtKB/Swiss-Prot:P9WG93"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45521.1"
/translation="MGASGLVWTLTIVLIAGLMLVDYVLHVRKTHVPTLRQAVIQSAT
FVGIAILFGIAVVVFGGSELAVEYFACYLTDEALSVDNLFVFLVIISSFGVPRLAQQK
VLLFGIAFALVTRTGFIFVGAALIENFNSAFYLFGLVLLVMAGNLARPTGLESRDAET
LKRSVIIRLADRFLRTSQDYNGDRLFTVSNNKRMMTPLLLVMIAVGGTDILFAFDSIP
ALFGLTQNVYLVFAATAFSLLGLRQLYFLIDGLLDRLVYLSYGLAVILGFIGVKLMLE
ALHDNKIPFINGGKPVPTVEVSTTQSLTVIIIVLLITTAASFWSARGRAQNAMARARR
YATAYLDLHYETESAERDKIFTALLAAERQINTLPTKYRMQPGQDDDLMTLLCRAHAA
RDAHM"
gene complement(3036131..3037291)
/gene="fadE20"
/locus_tag="Rv2724c"
CDS complement(3036131..3037291)
/codon_start=1
/transl_table=11
/gene="fadE20"
/locus_tag="Rv2724c"
/product="Probable acyl-CoA dehydrogenase FadE20"
/note="Rv2724c, (MTCY154.04c), len: 386 aa. Probable
fadE20, acyl-CoA dehydrogenase, highly similar to many
e.g. Q9X7Y2|SC6A5.36 from Streptomyces coelicolor (382
aa),FASTA scores: opt: 1583, E(): 6.9e-94, (62.7% identity
in 378 aa overlap); Q9HVY0|PA4435 from Pseudomonas
aeruginosa (381 aa), FASTA scores: opt: 1468, E():
1.6e-86, (57.65% identity in 380 aa overlap);
Q9ABZ1|CC0079 from Caulobacter crescentus (391 aa), FASTA
scores: opt: 1298, E(): 1.2e-75,(51.9% identity in 391 aa
overlap); etc. Also similar to many other Mycobacterium
tuberculosis proteins e.g.
O06164|FADE19|Rv2500c|MTCY07A7.06c acyl-CoA dehydrogenase
(394 aa) (34.3% identity in 382 aa overlap). Contains
acyl-CoA dehydrogenases signature 2 (PS00073). Belongs to
the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv2724c"
/db_xref="EnsemblGenomes-Tr:CCP45522"
/db_xref="GOA:O33229"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:O33229"
/inference="protein motif:PROSITE:PS00073"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45522.1"
/translation="MGSATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIV
DRGVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFGLHNDIVA
PYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDLQGITTRAVKHGDHYVLNGS
KTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVERGMAGFERGRQLDKIGLDAQDTAE
LSFTDVAVPAENLLGQEGMGFIYLMQNLPQERISIAIMAAAGMESVLEQTLQYAKERK
AFGRSIGSFQNSRFLLAELATEATVVRIMVDEFIKLHLAGKLTAEQAAMAKWYATEKQ
VYLNDRCLQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV"
gene complement(3037427..3038914)
/gene="hflX"
/locus_tag="Rv2725c"
CDS complement(3037427..3038914)
/codon_start=1
/transl_table=11
/gene="hflX"
/locus_tag="Rv2725c"
/product="Probable GTP-binding protein HflX"
/note="Rv2725c, (MTCY154.05c), len: 495 aa. Probable hflX
(hfl for high frequency of lysogenization), GTP-binding
protein ,equivalent to Q9CCC0|ML0997 (alias Q49843|HFLX
but longer) possible ATP/GTP-binding protein from
Mycobacterium leprae (488 aa), FASTA scores: opt: 2562,
E(): 1.1e-133,(84.55% identity in 485 aa overlap). Also
highly similar to many e.g. Q9XCC1 from Streptomyces
fradiae (425 aa), FASTA scores: opt: 1280, E(): 3.2e-63,
(57.7% identity in 423 aa overlap); P73965|HFLX|SLR1521
from Synechocystis sp. strain PCC 6803 (534 aa), FASTA
scores: opt: 1028, E(): 2.8e-49,(44.7% identity in 414 aa
overlap); P25519|HFLX_ECOLI|B4173 from Escherichia coli
strain K12 (426 aa), FASTA scores: opt: 916, E(): 3.4e-43,
(40.1% identity in 414 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2725c"
/db_xref="EnsemblGenomes-Tr:CCP45523"
/db_xref="GOA:O33230"
/db_xref="InterPro:IPR006073"
/db_xref="InterPro:IPR016496"
/db_xref="InterPro:IPR025121"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR030394"
/db_xref="InterPro:IPR032305"
/db_xref="InterPro:IPR042108"
/db_xref="UniProtKB/TrEMBL:O33230"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45523.1"
/translation="MPANSDARPAATCHHRVLAMTYPDPPQTGLSDFTPSLGELALED
RSALRRVAGLSTELADVSEVEYRQLRLERVVLVGVWTEGSAADNRASLAELAALAETA
GSQVLEGLIQRRDKPDPSTYIGSGKAAELREVIVATGADTVICDGELSPAQLTALEKA
VQVKVIDRTALILDIFAQHATSREGKAQVSLAQMEYMLPRLRGWGESMSRQAGGRAGG
SGGGVGLRGPGETKIETDRRRIRERMAKLRRDIRAMKQVRDTQRSRRRHSDVPSIAIV
GYTNAGKSSLLNALTGAGVLVQDALFATLEPTTRRAEFGDGRPVVLTDTVGFVRHLPT
QLVEAFRSTLEEVVHADLLVHVVDGSDGHPLAQIDAVRQVISEVIADHDGDPPPELLV
VNKVDVASDLMLAKLRHGLPGAVFVSARTGDGIDALRRRMAELVVPADTAVDVVIPYD
RGDLVARVHADGRIQQAEHKPEGTRIKARVPEALAATLREFAPRA"
gene complement(3038931..3039800)
/gene="dapF"
/locus_tag="Rv2726c"
CDS complement(3038931..3039800)
/codon_start=1
/transl_table=11
/gene="dapF"
/locus_tag="Rv2726c"
/product="Probable diaminopimelate epimerase DapF (DAP
epimerase)"
/note="Rv2726c, (MTCY154.06c), len: 289 aa. Probable
dapF,diaminopimelate epimerase, equivalent to
P46814|DAPF_MYCLE|ML0996|B2235_C3_233 diaminopimelate
epimerase from Mycobacterium leprae (296 aa), FASTA
scores: opt: 1488, E(): 2.1e-83, (76.05% identity in 292
aa overlap). Also highly similar to
O69969|DAPF_STRCO|SC4H2.14 from Streptomyces coelicolor
(289 aa), FASTA scores: opt: 439, E(): 1.4e-19, (45.6%
identity in 296 aa overlap); and similar to many e.g.
O29511|DAPF_ARCFU|AF0747 from Archaeoglobus fulgidus (280
aa), FASTA scores: opt: 310,E(): 9.7e-12, (33.8% identity
in 296 aa overlap); Q51564|DAPF_PSEAE|PA5278 from
Pseudomonas aeruginosa (276 aa), FASTA scores: opt: 272,
E(): 2e-09, (30.15% identity in 292 aa overlap);
P08885|DAPF_ECOLI|B3809 from Escherichia coli strain K12
(274 aa), FASTA scores: opt: 266, E(): 4.5e-09, (30.4%
identity in 296 aa overlap); etc. Belongs to the
diaminopimelate epimerase family."
/db_xref="EnsemblGenomes-Gn:Rv2726c"
/db_xref="EnsemblGenomes-Tr:CCP45524"
/db_xref="GOA:P9WP19"
/db_xref="InterPro:IPR001653"
/db_xref="InterPro:IPR018510"
/db_xref="PDB:3FVE"
/db_xref="UniProtKB/Swiss-Prot:P9WP19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45524.1"
/translation="MIFAKGHGTQNDFVLLPDVDAELVLTAARVAALCDRRKGLGADG
VLRVTTAGAAQAVGVLDSLPEGVRVTDWYMDYRNADGSAAQMCGNGVRVFAHYLRASG
LEVRDEFVVGSLAGPRPVTCHHVEAAYADVSVDMGKANRLGAGEAVVGGRRFHGLAVD
VGNPHLACVDSQLTVDGLAALDVGAPVSFDGAQFPDGVNVEVLTAPVDGAVWMRVHER
GVGETRSCGTGTVAAAVAALAAVGSPTGTLTVHVPGGEVVVTVTDATSFLRGPSVLVA
RGDLADDWWNAMG"
gene complement(3039825..3040769)
/gene="miaA"
/locus_tag="Rv2727c"
CDS complement(3039825..3040769)
/codon_start=1
/transl_table=11
/gene="miaA"
/locus_tag="Rv2727c"
/product="Probable tRNA delta(2)-isopentenylpyrophosphate
transferase MiaA (IPP transferase)
(isopentenyl-diphosphate:tRNA isopentenyltransferase)
(iptase) (IPPT)"
/note="Rv2727c, (MTCY154.07c), len: 314 aa. Probable
miaA,tRNA delta(2)-isopentenylpyrophosphate
transferase,equivalent to
P46811|MIAA_MYCLE|ML0995|B2235_C3_232 tRNA
delta(2)-isopentenylpyrophosphate transferase from
Mycobacterium leprae (311 aa), FASTA scores: opt:
1679,E(): 3.2e-89, (81.85% identity in 314 aa overlap).
Also highly similar to many e.g.
O69967|MIAA_STRCO|SC4H2.12 from Streptomyces coelicolor
(312 aa), FASTA scores: opt: 1006,E(): 1.2e-50, (55.5%
identity in 301 aa overlap); O31795|MIAA_BACSU from
Bacillus subtilis (314 aa), FASTA scores: opt: 671, E():
1.9e-31, (38.55% identity in 293 aa
overlap);P16384|MIAA_ECOLI|TRPX|B4171 from Escherichia
coli strain K12 and Shigella flexneri (316 aa), FASTA
scores: opt: 565, E(): 2.3e-25, (35.2% identity in 307 aa
overlap);etc. Contains PS00017 ATP/GTP-binding site motif
A (P -loop). Belongs to the IPP transferase family."
/db_xref="EnsemblGenomes-Gn:Rv2727c"
/db_xref="EnsemblGenomes-Tr:CCP45525"
/db_xref="GOA:P9WJW1"
/db_xref="InterPro:IPR018022"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR039657"
/db_xref="UniProtKB/Swiss-Prot:P9WJW1"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45525.1"
/translation="MRPLAIIGPTGAGKSQLALDVAARLGARVSVEIVNADAMQLYRG
MDIGTAKLPVSERRGIPHHQLDVLDVTETATVARYQRAAAADIEAIAARGAVPVVVGG
SMLYVQSLLDDWSFPATDPSVRARWERRLAEVGVDRLHAELARRDPAAAAAILPTDAR
RTVRALEVVELTGQPFAASAPRIGAPRWDTVIVGLDCQTTILDERLARRTDLMFDQGL
VEEVRTLLRNGLREGVTASRALGYAQVIAALDAGAGADMMRAAREQTYLGTRRYVRRQ
RSWFRRDHRVHWLDAGVASSPDRARLVDDAVRLWRHVT"
gene complement(3040766..3041461)
/locus_tag="Rv2728c"
CDS complement(3040766..3041461)
/codon_start=1
/transl_table=11
/locus_tag="Rv2728c"
/product="Conserved alanine rich protein"
/note="Rv2728c, (MTCY154.08c), len: 231 aa. Conserved
ala-rich protein, equivalent to Q49835|ML0994|B2235_C1_162
hypothetical protein from Mycobacterium leprae (232
aa),FASTA scores: opt: 1037, E(): 1.2e-54, (68.55%
identity in 232 aa overlap). Also similar to
O69964|SC4H2.09 from Streptomyces coelicolor (237 aa),
FASTA scores: opt: 300,E(): 7.7e-11, (32.8% identity in
241 aa overlap); and some similarity with other proteins
e.g. Q14234|ELN elastin from Homo sapiens (Human) (757
aa), FASTA scores: opt: 161, E(): 0.03, (30.6% identity in
242 aa overlap); P55488|Y4IE hypothetical 15.4 KDA protein
from Rhizobium sp. strain NGR234 (135 aa), FASTA scores:
opt: 147, E(): 0.061,(34.95% identity in 123 aa overlap).
Shows also some similarity with P71657|Rv1387|MTCY21B4.04
hypothetical protein from Mycobacterium tuberculosis (539
aa), FASTA scores: opt: 159, E(): 0.035, (34.8% identity
in 135 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2728c"
/db_xref="EnsemblGenomes-Tr:CCP45526"
/db_xref="UniProtKB/TrEMBL:I6X579"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45526.1"
/translation="MLSAIGIVPSAPVLVPELAGAAAAELADLGAAVIAAASLLPKSW
IAVGTGRADDVVRPTDVGTFAGFGADVRVGLAPQDGDGVAVPVELPLCALLTAWVRGQ
ARPEARAQVHVYASDHGSDAAVARGRQLRADIDREPDPIGVLVVADGLNTLTPRAPGG
YDPDGAGMQRALDDALASGDLAVLTRLPAQVLGRVAFQVLAGLAEPGPRSAKEFYRGA
PHGVGYFAGVWQP"
gene complement(3041570..3042475)
/locus_tag="Rv2729c"
CDS complement(3041570..3042475)
/codon_start=1
/transl_table=11
/locus_tag="Rv2729c"
/product="Probable conserved integral membrane alanine
valine and leucine rich protein"
/note="Rv2729c, (MTCY154.09c), len: 301 aa. Probable
conserved integral membrane ala-, val-, leu-rich
protein,similar to P42459|YLEU_CORGL hypothetical 29.6 KDA
protein from Corynebacterium glutamicum (Brevibacterium
flavum)(270 aa), FASTA scores: opt: 365, E(): 4.7e-15,
(30.75% identity in 221 aa overlap); and to other integral
membrane proteins (principally from Streptomyces sp.) e.g.
Q9EWZ8|2SCG38.21 from Streptomyces coelicolor (302 aa),
FASTA scores: opt: 365, E(): 5.2e-15, (32.0% identity in
278 aa overlap); Q9S267|SCI30A.06 from Streptomyces
coelicolor (297 aa),FASTA scores: opt: 356, E(): 1.8e-14,
(31.5% identity in 289 aa overlap); AAK81278|CAC3346 from
Clostridium acetobutylicum (472 aa), FASTA scores: opt:
154, E(): 0.038, (24.1% identity in 224 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2729c"
/db_xref="EnsemblGenomes-Tr:CCP45527"
/db_xref="GOA:O33234"
/db_xref="UniProtKB/TrEMBL:O33234"
/protein_id="CCP45527.1"
/translation="MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHFTLF
HLSLRHALWWLGSLAAVASFTLQAIALTMGSVVLVQSLQATALLFALLIDARLTHHRC
TPREWMWAVLLAGAVAVIVMSGNPAAGTTRAPFSTWAVVAVVVVPAVVLCVVGARIAS
GSLSAVLLAVASSATLAVFTVLTKGVVTELGEGFATLIRTPALYAWILVLPIGLMLQQ
SSLRVGALTASLPTITVARPVIASVLGITVLDEVLHTGRVALVALVAAVVVVVVATVA
LARDEVAMMTVSAGELGAAGQLAVR"
gene 3042542..3043018
/locus_tag="Rv2730"
CDS 3042542..3043018
/codon_start=1
/transl_table=11
/locus_tag="Rv2730"
/product="Hypothetical protein"
/note="Rv2730, (MTCY174.10), len: 158 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2730"
/db_xref="EnsemblGenomes-Tr:CCP45528"
/db_xref="UniProtKB/TrEMBL:I6Y1K4"
/protein_id="CCP45528.1"
/translation="MMMNWRQTNITTKRCAQTRASSSASEFCGIFAAPGLMRNCHHGG
SAPSAVGGSAVQLTVAYGPQRFHGRCASNSSVRPLTTGGSWTPTSISSTDGGKAQGHD
THDRQISRRTVCQAASILASILLETVAGPGEGIGPTTSVPLRAADARHTREGLQGR"
gene 3043026..3044378
/locus_tag="Rv2731"
CDS 3043026..3044378
/codon_start=1
/transl_table=11
/locus_tag="Rv2731"
/product="Conserved alanine and arginine rich protein"
/note="Rv2731, (MTCY174.11), len: 450 aa. Conserved
ala-,arg-rich protein, highly similar in part to
Q49849|B2235_F2_77 hypothetical protein from Mycobacterium
leprae (266 aa), FASTA scores: opt: 368, E(): 1e-10,
(73.5% identity in 83 aa overlap); and Q9KXN9|SC9C5.35
hypothetical 6.5 KDA protein (fragment) from Streptomyces
coelicolor (58 aa), FASTA scores: opt: 214, E():
0.00065,(51.7% identity in 58 aa overlap). Also similar to
Q9L296|SCL2.01 hypothetical 37.4 KDA protein (fragment)
from Streptomyces coelicolor (328 aa), FASTA scores: opt:
843, E(): 3.7e-33, (45.95% identity in 296 aa overlap)
(but N-terminus shorter); and shows some similarity with
other proteins e.g. Q26938 kinetoplast-associated protein
(KAP) from Trypanosoma cruzi (1052 aa), FASTA scores: opt:
223,E(): 0.0022, (30.3% identity in 297 aa overlap). Start
site chosen by RBS and to avoid overlap, although there
are several other possible start sites further upstream."
/db_xref="EnsemblGenomes-Gn:Rv2731"
/db_xref="EnsemblGenomes-Tr:CCP45529"
/db_xref="InterPro:IPR007139"
/db_xref="UniProtKB/TrEMBL:I6XF60"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45529.1"
/translation="MTADEPRSDDSSGSAPQPAATPVPRPGPRPGPRPVPRPTSYPVG
AHPPSDPHRFGRIDDDGTVWLVSASGERIVGSWQAGDPEAAFAHFGRRFDDLSTEIML
MDERLASGTGDARKIKAHAIALAETLPTACVLGDVDALADRLTSIRDRAEVIAAADRS
RREEHRAAQTARKEALAAEAEELAANATQWKVAGDRLRAILDEWKTISGVDRKVDDAL
WKRYSTARDTFNRRRGSHFAELDRERSGVRQSKERLCERAEELSESTDWTATSAEFRK
LLADWKAAGRASKDVDDALWRRFKAAQDSFFTARNAATAEKEAELRANADAKEALLAE
AERLDTTNHEAARAALRSIAEKWDAIGKVSRERAAELERRLRAVEKKVREAGEADWSD
PQARARAEQFRARAEQFEHQAEKAAAAGRTKEADEAKANAEQWRQWAEAAADALTRRP
"
gene complement(3044375..3044989)
/locus_tag="Rv2732c"
CDS complement(3044375..3044989)
/codon_start=1
/transl_table=11
/locus_tag="Rv2732c"
/product="Probable conserved transmembrane protein"
/note="Rv2732c, (MTCY174.12c), len: 204 aa. Probable
conserved transmembrane protein, similar to Q49834
hypothetical protein B2235_C1_155 from Mycobacterium
leprae (209 aa), FASTA scores: opt: 932, E(): 0, (70.6%
identity in 201 aa overlap). Contains PS00343
Gram-positive cocci surface proteins 'anchoring'
hexapeptide. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2732c"
/db_xref="EnsemblGenomes-Tr:CCP45530"
/db_xref="GOA:O33237"
/db_xref="UniProtKB/TrEMBL:O33237"
/inference="protein motif:PROSITE:PS00343"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45530.1"
/translation="MMSHEHDAGDLDALRAEIEAAERRVAREIEPGARALVVAILVFV
LLGSFILPHTGSVRGWDVLFSSHGAGRAAVALPSRVFAWLALVFGVGFSMLALLTRRW
ALAWVALAGSAMASGTGLLAVWSRQTVAAGHPGPGIGLIVAWITAIVLTFHWAQVVWS
RTIVQLAAEERRRRVVAQQQCKTLLDHVQTDSEAGTTPDRGTDR"
gene complement(3044986..3046524)
/locus_tag="Rv2733c"
CDS complement(3044986..3046524)
/codon_start=1
/transl_table=11
/locus_tag="Rv2733c"
/product="Conserved hypothetical alanine, arginine-rich
protein"
/note="Rv2733c, (MTCY154.13c), len: 512 aa. Conserved
hypothetical ala-, arg-rich protein. Similar to other
hypothetical proteins from a range of organisms e.g.
Y195_MYCLE|Q49842 hypothetical 56.0 kDa protein
b2235_c2_195 from Mycobacterium leprae (516 aa), FASTA
scores: opt: 2689, E(): 0, (80.4% identity in 509 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2733c"
/db_xref="EnsemblGenomes-Tr:CCP45531"
/db_xref="GOA:P9WK05"
/db_xref="InterPro:IPR002792"
/db_xref="InterPro:IPR005839"
/db_xref="InterPro:IPR006463"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013848"
/db_xref="InterPro:IPR020612"
/db_xref="InterPro:IPR023404"
/db_xref="InterPro:IPR038135"
/db_xref="UniProtKB/Swiss-Prot:P9WK05"
/protein_id="CCP45531.1"
/translation="MVAHDAAAGVTGEGAGPPVRRAPARTYQVRTYGCQMNVHDSERL
AGLLEAAGYRRATDGSEADVVVFNTCAVRENADNRLYGNLSHLAPRKRANPDMQIAVG
GCLAQKDRDAVLRRAPWVDVVFGTHNIGSLPTLLERARHNKVAQVEIAEALQQFPSSL
PSSRESAYAAWVSISVGCNNSCTFCIVPSLRGREVDRSPADILAEVRSLVNDGVLEVT
LLGQNVNAYGVSFADPALPRNRGAFAELLRACGDIDGLERVRFTSPHPAEFTDDVIEA
MAQTRNVCPALHMPLQSGSDRILRAMRRSYRAERYLGIIERVRAAIPHAAITTDLIVG
FPGETEEDFAATLDVVRRARFAAAFTFQYSKRPGTPAAQLDGQLPKAVVQERYERLIA
LQEQISLEANRALVGQAVEVLVATGEGRKDTVTARMSGRARDGRLVHFTAGQPRVRPG
DVITTKVTEAAPHHLIADAGVLTHRRTRAGDAHTAGQPGRAVGLGMPGVGLPVSAAKP
GGCR"
gene 3046821..3047675
/locus_tag="Rv2734"
CDS 3046821..3047675
/codon_start=1
/transl_table=11
/locus_tag="Rv2734"
/product="Conserved hypothetical protein"
/note="Rv2734, (MTCY154.14), len: 284 aa. Conserved
hypothetical protein, highly similar to various proteins
e.g. Q984J2|MLR7981 ABC transporter ATP-binding protein
from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA
scores: opt: 877, E(): 9e-50, (52.45% identity in 246 aa
overlap) (N-terminus longer); Q98DH1|MLL4707 hypothetical
protein from Rhizobium loti (Mesorhizobium loti) (249
aa),FASTA scores: opt: 829, E(): 1.1e-46, (50.4% identity
in 244 aa overlap); AAK65865|SMA2239 conserved
hypothetical protein from Rhizobium meliloti
(Sinorhizobium meliloti) (259 aa), FASTA scores: opt: 796,
E(): 1.5e-44, (50.0% identity in 252 aa overlap); etc.
This region is a possible MT-complex-specific genomic
island (See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2734"
/db_xref="EnsemblGenomes-Tr:CCP45532"
/db_xref="InterPro:IPR011101"
/db_xref="UniProtKB/TrEMBL:I6YA42"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45532.1"
/translation="MSDRSAIEWTGATWNPVTGCDRVSPGCDHCYAMTLAKRLKAMGS
DKYQTDGDPRTSGPGFGVTIHPRSLDEPFRWRSPRTVFVNSMADLFHARVALWFIREV
FEVMRATPQHTYQILTKRSLRLRRLAHKLEWPSNVWMGVSVENVDAFRRIEDLRQVPA
AVRFLSCEPLLGPLDGINLGSIDWVIAGGESGPNFRPIDPQWVRHIRDTCTAADVPFF
FKQWGGRTPKAFGRELDGRCWDEMPLIEIRNPDPRTTSRVHADPMLATAPTESAQRSN
PGQLVRQR"
gene complement(3047560..3048552)
/locus_tag="Rv2735c"
CDS complement(3047560..3048552)
/codon_start=1
/transl_table=11
/locus_tag="Rv2735c"
/product="Conserved hypothetical protein"
/note="Rv2735c, (MTCY154.15c), len: 330 aa. Conserved
hypothetical protein, showing some similarity with
Q98DH2|MLR4706 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (302 aa), FASTA scores: opt: 140,
E(): 0.062, (27.0% identity in 200 aa overlap); and
Q9PHA1|XF0043 hypothetical protein from Xylella fastidiosa
(293 aa), FASTA scores: opt: 120, E(): 1.2, (30.75%
identity in 117 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2735c"
/db_xref="EnsemblGenomes-Tr:CCP45533"
/db_xref="InterPro:IPR031009"
/db_xref="UniProtKB/TrEMBL:I6Y1K7"
/protein_id="CCP45533.1"
/translation="MAREWSYWTRNKLEILAGYLPAFNRASQTSRERIYLDLMAGQPE
NIDRDMGEKFDGSSLIAMKADPPFTRLRFCELNPLASELDVALRTRFPGDGRYRVVAG
DSNVTIDETLAELGPWRWAPTFAFIDQQAAEVHWETINKVAAFRQNPRNLKTELWMLM
SPTMIARGVKGTNAELFIEQVTRMYGDADWKRIQAARWRHHLTAPAYRAEMVNLMRVK
LEYELGYKYSHRIPMQMHNKVTIFDMVFATDHWAGDAIMCHLYNRAAQKEPEMMRQAK
SAKQQKESEDRGEMGLFSVGELAVQDSNAGQILWAPSPTWDPRARGWWSEDPGF"
gene complement(3048562..3049086)
/gene="recX"
/locus_tag="Rv2736c"
CDS complement(3048562..3049086)
/codon_start=1
/transl_table=11
/gene="recX"
/locus_tag="Rv2736c"
/product="Regulatory protein RecX"
/note="Rv2736c, (MTV002.01c), len: 174 aa. Probable
recX,regulatory protein (see citation below), equivalent
to P37859|RECX_MYCLE|ML0988|U2235B regulatory protein RECX
from Mycobacterium leprae (171 aa), FASTA scores: opt:
848,E(): 2e-46, (77.0% identity in 174 aa overlap); and
CAA67596|RECX|P94965|RECX_MYCSM regulatory protein RECX
from Mycobacterium smegmatis (188 aa), FASTA scores: opt:
679, E(): 8.8e-36, (66.45% identity in 164 aa overlap).
Also similar (or highly similar to) others e.g.
O50488|RECX_STRCO|SC4H8.09 from Streptomyces coelicolor
(188 aa), FASTA scores: opt: 371, E(): 1.9e-16, (42.7%
identity in 164 aa overlap); Q9LCZ3|RECX from Xanthomonas
campestris pv. citri (162 aa), FASTA scores: opt: 189,
E(): 4.4e-05, (32.45% identity in 151 aa overlap);
P37860|RECX_PSEAE|PA3616 from Pseudomonas aeruginosa (153
aa), FASTA scores: opt: 159, E(): 0.0032, (30.65% identity
in 137 aa overlap); etc. Belongs to the RecX family."
/db_xref="EnsemblGenomes-Gn:Rv2736c"
/db_xref="EnsemblGenomes-Tr:CCP45534"
/db_xref="GOA:P9WHI1"
/db_xref="InterPro:IPR003783"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WHI1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45534.1"
/translation="MTVSCPPPSTSEREEQARALCLRLLTARSRTRAELAGQLAKRGY
PEDIGNRVLDRLAAVGLVDDTDFAEQWVQSRRANAAKSKRALAAELHAKGVDDDVITT
VLGGIDAGAERGRAEKLVRARLRREVLIDDGTDEARVSRRLVAMLARRGYGQTLACEV
VIAELAAERERRRV"
gene complement(3049052..3051424)
/gene="recA"
/locus_tag="Rv2737c"
CDS complement(3049052..3051424)
/codon_start=1
/transl_table=11
/gene="recA"
/locus_tag="Rv2737c"
/product="RecA protein (recombinase A) [contains:
endonuclease PI-MTUI (MTU RecA intein)]."
/note="Rv2737c, (MTV002.02c), len: 790 aa.
RecA,recombinase a (see citations below), equivalent to
Q59560|RECA_MYCSM RECA protein from Mycobacterium
smegmatis (349 aa), FASTA scores: opt: 1495, E(): 1.9e-79,
(93.15% identity in 249 aa overlap); and
P35901|RECA_MYCLE|ML0987 RECA protein from Mycobacterium
leprae (711 aa), FASTA scores: opt: 1217, E(): 4.5e-63,
(46.7% identity in 814 aa overlap). Also highly similar to
many e.g. Q9REV6|RECA_AMYMD from Amycolatopsis
mediterranei (Nocardia mediterranei) (348 aa), FASTA
scores: opt: 1450, E(): 7.6e-77, (89.25% identity in 251
aa overlap); P42442|RECA_CORGL from Corynebacterium
glutamicum (Brevibacterium flavum) (376 aa), FASTA scores:
opt: 1355,E(): 2.6e-71, (76.55% identity in 273 aa
overlap); P41054|RECA_STRAM from Streptomyces ambofaciens
(372 aa),FASTA scores: opt: 1347, E(): 7.6e-71, (82.1%
identity in 246 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop), PS00321 recA
signature, and PS00881 Protein splicing signature. Belongs
to the RecA family. This protein undergoes a protein self
splicing that involves a post-translational excision of
the intervening region (intein) followed by peptide
ligation. Belongs to the homing endonuclease family in the
intein section."
/db_xref="EnsemblGenomes-Gn:Rv2737c"
/db_xref="EnsemblGenomes-Tr:CCP45535"
/db_xref="GOA:P9WHJ3"
/db_xref="InterPro:IPR003586"
/db_xref="InterPro:IPR003587"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004042"
/db_xref="InterPro:IPR004860"
/db_xref="InterPro:IPR006141"
/db_xref="InterPro:IPR006142"
/db_xref="InterPro:IPR013765"
/db_xref="InterPro:IPR020584"
/db_xref="InterPro:IPR020587"
/db_xref="InterPro:IPR020588"
/db_xref="InterPro:IPR023400"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR027434"
/db_xref="InterPro:IPR030934"
/db_xref="InterPro:IPR036844"
/db_xref="PDB:1G18"
/db_xref="PDB:1G19"
/db_xref="PDB:1MO3"
/db_xref="PDB:1MO4"
/db_xref="PDB:1MO5"
/db_xref="PDB:1MO6"
/db_xref="PDB:2IMZ"
/db_xref="PDB:2IN0"
/db_xref="PDB:2IN8"
/db_xref="PDB:2IN9"
/db_xref="PDB:2L8L"
/db_xref="PDB:3IFJ"
/db_xref="PDB:3IGD"
/db_xref="PDB:4OQF"
/db_xref="PDB:4PO1"
/db_xref="PDB:4PO8"
/db_xref="PDB:4PO9"
/db_xref="PDB:4POA"
/db_xref="PDB:4PPF"
/db_xref="PDB:4PPG"
/db_xref="PDB:4PPN"
/db_xref="PDB:4PPQ"
/db_xref="PDB:4PQF"
/db_xref="PDB:4PQR"
/db_xref="PDB:4PQY"
/db_xref="PDB:4PR0"
/db_xref="PDB:4PSA"
/db_xref="PDB:4PSK"
/db_xref="PDB:4PSV"
/db_xref="PDB:4PTL"
/db_xref="PDB:5I0A"
/db_xref="PDB:5K08"
/db_xref="UniProtKB/Swiss-Prot:P9WHJ3"
/inference="protein motif:PROSITE:PS00881"
/inference="protein motif:PROSITE:PS00321"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45535.1"
/translation="MTQTPDREKALELAVAQIEKSYGKGSVMRLGDEARQPISVIPTG
SIALDVALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHALDP
DYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAALVPRAELEGEM
GDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDKIGVMFGSPETTTGGKALKF
YASVRMDVRRVETLKDGTNAVGNRTRVKVVKNKCLAEGTRIFDPVTGTTHRIEDVVDG
RKPIHVVAAAKDGTLHARPVVSWFDQGTRDVIGLRIAGGAIVWATPDHKVLTEYGWRA
AGELRKGDRVAQPRRFDGFGDSAPIPADHARLLGYLIGDGRDGWVGGKTPINFINVQR
ALIDDVTRIAATLGCAAHPQGRISLAIAHRPGERNGVADLCQQAGIYGKLAWEKTIPN
WFFEPDIAADIVGNLLFGLFESDGWVSREQTGALRVGYTTTSEQLAHQIHWLLLRFGV
GSTVRDYDPTQKRPSIVNGRRIQSKRQVFEVRISGMDNVTAFAESVPMWGPRGAALIQ
AIPEATQGRRRGSQATYLAAEMTDAVLNYLDERGVTAQEAAAMIGVASGDPRGGMKQV
LGASRLRRDRVQALADALDDKFLHDMLAEELRYSVIREVLPTRRARTFDLEVEELHTL
VAEGVVVHNCSPPFKQAEFDILYGKGISREGSLIDMGVDQGLIRKSGAWFTYEGEQLG
QGKENARNFLVENADVADEIEKKIKEKLGIGAVVTDDPSNDGVLPAPVDF"
gene 3051619..3051792
/locus_tag="Rv2737A"
CDS 3051619..3051792
/codon_start=1
/transl_table=11
/locus_tag="Rv2737A"
/product="Conserved hypothetical cysteine rich protein
(fragment)"
/note="Rv2737A, len: 57 aa. Conserved hypothetical
cys-rich protein (possibly gene fragment), similar to
central part of AJ243803_1|glgA from Streptomyces
coelicolor glgA (181 aa), FASTA scores: opt: 210, E():
6.1e-09, (59.25% identity in 54 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2737A"
/db_xref="EnsemblGenomes-Tr:CCP45536"
/db_xref="GOA:Q79FB4"
/db_xref="InterPro:IPR024726"
/db_xref="UniProtKB/TrEMBL:Q79FB4"
/protein_id="CCP45536.1"
/translation="MRPDLRARLVRITDDLLNTASLAGSGVLTGPDLTFRRRSCCLFY
RVPAGGKCGDCPL"
gene complement(3051806..3052012)
/locus_tag="Rv2738c"
CDS complement(3051806..3052012)
/codon_start=1
/transl_table=11
/locus_tag="Rv2738c"
/product="Conserved hypothetical protein"
/note="Rv2738c, (MTV002.03c), len: 68 aa. Conserved
hypothetical protein, equivalent to Q9CCC1|ML0986
hypothetical protein from Mycobacterium leprae (67
aa),FASTA scores: opt: 397, E(): 3.7e-22, (83.6% identity
in 67 aa overlap). Also highly similar to O50484|SC4H8.05
hypothetical 7.5 KDA protein from Streptomyces coelicolor
(64 aa), FASTA scores: opt: 185, E(): 5.9e-07, (39.7%
identity in 63 aa overlap). Second part of the protein is
highly similar to C-terminus of upstream ORF
O33285|Rv2742c|MTV002.07c conserved hypothetical protein
from Mycobacterium tuberculosis (277 aa), FASTA scores:
opt: 200, E(): 1.7e-07, (78.4% identity in 37 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2738c"
/db_xref="EnsemblGenomes-Tr:CCP45537"
/db_xref="InterPro:IPR021408"
/db_xref="UniProtKB/TrEMBL:I6YA47"
/protein_id="CCP45537.1"
/translation="MLAGVRLTEFHERVALHFGAAYGSSVLLDHVLTGFDGRSAAQAI
EDGVEPRDVWRALCADFDVPHDRW"
gene complement(3052023..3053189)
/locus_tag="Rv2739c"
CDS complement(3052023..3053189)
/codon_start=1
/transl_table=11
/locus_tag="Rv2739c"
/product="Possible alanine rich transferase"
/note="Rv2739c, (MTV002.04c), len: 388 aa. Possible
ala-rich transferase, equivalent to
Q49841|ML0985|MLCB33.02c|U2235C possible
glycosyltransferase from Mycobacterium leprae (392
aa),FASTA scores: opt: 2112, E(): 5.1e-114, (80.95%
identity in 388 aa overlap). Shows some similarity with
other transferases e.g. Q9S1V2|SCJ4.21 putative glycosyl
transferase from Streptomyces coelicolor (407 aa), FASTA
scores: opt: 290, E(): 2e-09, (27.75% identity in 382 aa
overlap); Q9RYI3|DRA0329 putative glycosyltransferase from
Deinococcus radiodurans (418 aa), FASTA scores: opt:
267,E(): 4.3e-08, (29.05% identity in 396 aa overlap);
P96560|GTFC glycosyltransferase from Amycolatopsis
orientalis (409 aa), FASTA scores: opt: 253, E():
2.7e-07,(27.75% identity in 418 aa overlap); etc.
Equivalent to AAK47130 from Mycobacterium tuberculosis
strain CDC1551 (420 aa) but shorter 32 aa."
/db_xref="EnsemblGenomes-Gn:Rv2739c"
/db_xref="EnsemblGenomes-Tr:CCP45538"
/db_xref="GOA:O33282"
/db_xref="InterPro:IPR007235"
/db_xref="UniProtKB/TrEMBL:O33282"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45538.1"
/translation="MRVAVVAGPDPGHSFPAIALCQRFRAAADTPTLFTGVEWLEAAR
AAGIDAVELDGLAATDRDLDAGARIHRRAAQMAVLNVPRLRALEPELVVSDVITACGG
MAAELLGIPWVELNPHPLYLPSKGLPPIGSGLAAGTGIRGRLRDATMRALTGRSWRAG
LRQRAAVRVEIGLPARDPGPLRRLIATLPALEVPRPDWPAEAVVVGPLHFEPTDRVLA
IPAGTGPVVVVAPSTALTGTAGLTEVALQSLTPGETVPSGSRLVVSRLSGADLTVPPW
AVAGLGSQAELLTRADLVICGGGHGMVAKTLLAGVPMVVVPGGGDQWEIANRVVRQGS
AVLIRPLTADALVAAVNEVLSSPRFREAARRAAASVAGAADPVRVCHDALALAG"
gene 3053233..3053682
/gene="ephG"
/locus_tag="Rv2740"
CDS 3053233..3053682
/codon_start=1
/transl_table=11
/gene="ephG"
/locus_tag="Rv2740"
/product="Epoxide hydrolase"
/note="Rv2740, (MTV002.05), len: 149 aa. EphG, Epoxide
hydrolase, proven biochemically (see Unge et al.
2005),similar to limonene-1,2-epoxide hydrolase capable of
hydrolyzing long or bulky lipophilic epoxides.
Equivalent,but shorter 17 aa, to Q9CCC2|ML0984 (alias
Q49850 but longer) hypothetical protein from Mycobacterium
leprae (164 aa), FASTA scores: opt: 481, E(): 9.7e-26,
(52.0% identity in 150 aa overlap). A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2740"
/db_xref="EnsemblGenomes-Tr:CCP45539"
/db_xref="GOA:O33283"
/db_xref="InterPro:IPR013100"
/db_xref="InterPro:IPR032710"
/db_xref="PDB:2BNG"
/db_xref="UniProtKB/Swiss-Prot:O33283"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45539.1"
/translation="MAELTETSPETPETTEAIRAVEAFLNALQNEDFDTVDAALGDDL
VYENVGFSRIRGGRRTATLLRRMQGRVGFEVKIHRIGADGAAVLTERTDALIIGPLRV
QFWVCGVFEVDDGRITLWRDYFDVYDMFKGLLRGLVALVVPSLKATL"
gene 3053914..3055491
/gene="PE_PGRS47"
/locus_tag="Rv2741"
CDS 3053914..3055491
/codon_start=1
/transl_table=11
/gene="PE_PGRS47"
/locus_tag="Rv2741"
/product="PE-PGRS family protein PE_PGRS47"
/note="Rv2741, (MTV002.06), len: 525 aa. PE_PGRS47, Member
of the M. tuberculosis PE family, PGRS subfamily of
gly-rich proteins (see citation below), highly similar to
others e.g. Q10637|YD25_MYCTU|Rv1325c|MT1367|MTCY130.10c
hypothetical PE-PGRS family protein (603 aa), FASTA
scores: opt: 1936, E(): 1.1e-71, (56.95% identity in 611
aa overlap). Predicted to be an outer membrane protein
(See Song et al., 2008). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2741"
/db_xref="EnsemblGenomes-Tr:CCP45540"
/db_xref="GOA:Q79FB3"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:Q79FB3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45540.1"
/translation="MSFVIAAPEFLTAAAMDLASIGSTVSAASAAASAPTVAILAAGA
DEVSIAVAALFGMHGQAYQALSVQASAFHQQFVQALTAGAYSYASAEAAAVTPLQQLV
DVINAPFRSALGRPLIGNGANGKPGTGQDGGAGGLLYGSGGNGGSGLAGSGQKGGNGG
AAGLFGNGGAGGAGASNQAGNGGAGGNGGAGGLIWGTAGTGGNGGFTTFLDAAGGAGG
AGGAGGLFGAGGAGGVGGAALGGGAQAAGGNGGAGGVGGLFGAGGAGGAGGFSDTGGT
GGAGGAGGLFGPGGGSGGVGGFGDTGGTGGDGGSGGLFGVGGAGGHGGFGSAAGGDGG
AGGAGGTVFGSGGAGGAGGVATVAGHGGHGGNAGLLYGTGGAGGAGGFGGFGGDGGDG
GIGGLVGSGGAGGSGGTGTLSGGRGGAGGNAGTFYGSGGAGGAGGESDNGDGGNGGVG
GKAGLVGEGGNGGDGGATIAGKGGSGGNGGNAWLTGQGGNGGNAAFGKAGTGSVGVGG
AGGLLEGQNGENGLLPS"
gene complement(3055515..3056348)
/locus_tag="Rv2742c"
CDS complement(3055515..3056348)
/codon_start=1
/transl_table=11
/locus_tag="Rv2742c"
/product="Conserved hypothetical arginine rich protein"
/note="Rv2742c, (MTV002.07c), len: 277 aa (questionable
ORF). Conserved hypothetical arg-rich protein. Extreme
N-terminus is highly similar to the N-teminus of
Q9CCC1ML0986 hypothetical protein from Mycobacterium
leprae (67 aa), FASTA scores: opt: 183, E(): 0.00052,
(71.05% identity in 38 aa overlap); and to the downstream
ORF O33281|Rv2738c|MTV002.03c conserved hypothetical
protein from Mycobacterium tuberculosis (68 aa), FASTA
scores: opt: 200, E(): 5.5e-05, (78.4% identity in 37 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2742c"
/db_xref="EnsemblGenomes-Tr:CCP45541"
/db_xref="GOA:O33285"
/db_xref="InterPro:IPR021408"
/db_xref="UniProtKB/TrEMBL:O33285"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45541.1"
/translation="MLVDELGVKIVHAQHVPAPYLVQRMREIHERDENRQRHAQVDVQ
RRRDQPERGQHQHRRNRDADHHPDGRTLAGQIVAHPVSHRVRQPRPVAIADVLPRVGP
RADCVVAHSLQGSPRRRERRRGQTAHQRLGRRSGNAIACPLYLENAAGPEPDTKRAEG
RRFGAFGGGDLRWMADRVPRQGSGRRGLGSRSGAGVPQGADARGWRHTADGVPRVGQP
AIRRGVPGFWCWLDHVLTGFGGRNAICAIEDGVEPRVAWWALCTDFDVPRSMGRRTPG
G"
gene complement(3056420..3057232)
/locus_tag="Rv2743c"
CDS complement(3056420..3057232)
/codon_start=1
/transl_table=11
/locus_tag="Rv2743c"
/product="Possible conserved transmembrane alanine rich
protein"
/note="Rv2743c, (MTV002.08c), len: 270 aa. Possible
conserved transmembrane ala-rich protein, equivalent to
Q49833|MLCB33.04c|B2235_C1_148 unknown protein from
Mycobacterium leprae (123 aa), FASTA scores: opt: 639,
E(): 3.3e-31, (74.8% identity in 123 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2743c"
/db_xref="EnsemblGenomes-Tr:CCP45542"
/db_xref="GOA:I6YA50"
/db_xref="UniProtKB/TrEMBL:I6YA50"
/protein_id="CCP45542.1"
/translation="MAVKAGQRRPWRSLLQRGVDTAGDLADLVAQKISVAIDPRARLL
RRRRRALRWGLVFTAGCLLWGLVTALLAAWGWFTSLLVITGTIAVTQAIPATLLLLRY
RWLRSEPLPVRRPASVRRLPPPGSAARPAMSALGASERGFFSLLGVMERGAMLPADEI
RDLTAAANQTSAAMVATAAEVVSMERAVQCSAASRSYLVPTINAFTAQLSTGVRQYNE
MVTAAAQLVSSANGAGGAGPGQQRYREELAGATDRLVAWAQAFDELGGLPRR"
gene complement(3057251..3058063)
/gene="35kd_ag"
/locus_tag="Rv2744c"
CDS complement(3057251..3058063)
/codon_start=1
/transl_table=11
/gene="35kd_ag"
/locus_tag="Rv2744c"
/product="Conserved 35 kDa alanine rich protein"
/note="Rv2744c, (MTV002.09c), len: 270 aa.
35kd_ag,conserved ala-rich protein 35-kd antigen (see
O'Connor et al., 1990). N-terminal part is equivalent to
Q49840|MLCB33.06c|B2235_C2_187 hypothetical protein from
Mycobacterium leprae (167 aa), FASTA scores: opt: 789,
E(): 3.4e-35, (85.05% identity in 147 aa overlap); and
C-terminal part equivalent to
Q49845|MLCB33.05c|B2235_C3_214 hypothetical protein from
Mycobacterium leprae (114 aa), FASTA scores: opt: 465,
E(): 3.6e-18, (65.8% identity in 114 aa overlap); note
that these two proteins from Mycobacterium leprae are
adjacent. Shows some similarity with
Q55707||Y617_SYNY3|SLL0617 hypothetical 28.9 KDA protein
from Synechocystis sp. strain PCC 6803 (267 aa), FASTA
scores: opt: 155, E(): 0.19,(23.4% identity in 252 aa
overlap); and C-terminus of Q9L4N1|EMM M protein from
Streptococcus equisimilis (592 aa), FASTA scores: opt:
165, E(): 0.11, (23.45% identity in 260 aa overlap).
C-terminus also similar to AAK45945|MT1676 conserved
hypothetical protein from Mycobacterium tuberculosis
strain CDC1551 (85 aa), FASTA scores: opt: 159, E():
0.047, (50.9% identity in 55 aa overlap). Predicted
possible vaccine candidate (See Zvi et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv2744c"
/db_xref="EnsemblGenomes-Tr:CCP45543"
/db_xref="GOA:P9WHP5"
/db_xref="InterPro:IPR007157"
/db_xref="UniProtKB/Swiss-Prot:P9WHP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45543.1"
/translation="MANPFVKAWKYLMALFSSKIDEHADPKVQIQQAIEEAQRTHQAL
TQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAA
EAFAAQLVTAEQSVEDLKTLHDQALSAAAQAKKAVERNAMVLQQKIAERTKLLSQLEQ
AKMQEQVSASLRSMSELAAPGNTPSLDEVRDKIERRYANAIGSAELAESSVQGRMLEV
EQAGIQMAGHSRLEQIRASMRGEALPAGGTTATPRPATETSGGAIAEQPYGQ"
gene complement(3058193..3058531)
/gene="clgR"
/locus_tag="Rv2745c"
CDS complement(3058193..3058531)
/codon_start=1
/transl_table=11
/gene="clgR"
/locus_tag="Rv2745c"
/product="Transcriptional regulatory protein ClgR"
/note="Rv2745c, (MTV002.10c), len: 112 aa.
ClgR,transcriptional regulatory protein, controls protease
systems and chaperones."
/db_xref="EnsemblGenomes-Gn:Rv2745c"
/db_xref="EnsemblGenomes-Tr:CCP45544"
/db_xref="GOA:P9WMH7"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010982"
/db_xref="UniProtKB/Swiss-Prot:P9WMH7"
/protein_id="CCP45544.1"
/translation="MAALVREVVGDVLRGARMSQGRTLREVSDSARVSLGYLSEIERG
RKEPSSELLSAICTALQLPLSVVLIDAGERMARQERLARATPAGRATGATIDASTKVV
IAPVVSLAVA"
gene complement(3058602..3059231)
/gene="pgsA3"
/locus_tag="Rv2746c"
CDS complement(3058602..3059231)
/codon_start=1
/transl_table=11
/gene="pgsA3"
/locus_tag="Rv2746c"
/product="Probable PGP synthase PgsA3
(CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase) (phosphatidylglycerophosphate
synthase)"
/note="Rv2746c, (MTV002.11c), len: 209 aa. Probable
pgsA3,PGP synthase (see citation below), transmembrane
protein,equivalent, but longer 19 aa, to
Q49839|O08087|PGSA|ML0979 PGSA from Mycobacterium leprae
(193 aa), FASTA scores: opt: 925, E(): 3.7e-53, (77.15%
identity in 188 aa overlap). Also highly similar to
O86813|PGSA phosphatidylglycerophosphate synthase from
Streptomyces coelicolor (263 aa), FASTA scores: opt: 692,
E(): 6.6e-38,(57.85% identity in 185 aa overlap) (has its
N-terminus longer); and similar to others (generally with
N-terminus shorter) e.g. Q99XI0|PGSA|SPY2196
phosphatidylglycerophosphate synthase from Streptococcus
pyogenes (180 aa), FASTA scores: opt: 368, E():
5.4e-17,(39.9% identity in 168 aa overlap);
Q9ZE96|PGSA_RICPR|PGSA|RP049
CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase from Rickettsia prowazekii (181
aa), FASTA scores: opt: 343, E(): 2.3e-15, (40.1% identity
in 172 aa overlap);
P06978|PGSA_ECOLI|PGSA|B1912|Z3000|ECS2650
CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase from Escherichia coli strains
K12 and O157:H7 (181 aa), FASTA scores: opt: 322, E():
5.3e-14,(34.45% identity in 180 aa overlap); etc. Also
some similarity to PGSA2|Rv1822|MTCY1A11.21c probable
CDP-diacylglycerol--glycerol-3-phosphate
3-phosphatidyltransferase from Mycobacterium tuberculosis
(209 aa), FASTA score: (27.1% identity in 166 aa overlap).
Contains PS00379 CDP-alcohol phosphatidyltransferases
signature. Belongs to the CDP-alcohol
phosphatidyltransferase class-I family."
/db_xref="EnsemblGenomes-Gn:Rv2746c"
/db_xref="EnsemblGenomes-Tr:CCP45545"
/db_xref="GOA:P9WPG3"
/db_xref="InterPro:IPR000462"
/db_xref="InterPro:IPR004570"
/db_xref="UniProtKB/Swiss-Prot:P9WPG3"
/inference="protein motif:PROSITE:PS00379"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45545.1"
/translation="MSRSTRYSVAVSAQPETGQIAGRARIANLANILTLLRLVMVPVF
LLALFYGGGHHSAARVVAWAIFATACITDRFDGLLARNYGMATEFGAFVDPIADKTLI
GSALIGLSMLGDLPWWVTVLILTRELGVTVLRLAVIRRGVIPASWGGKLKTFVQAVAI
GLFVLPLSGPLHVAAVVVMAAAILLTVITGVDYVARALRDIGGIRQTAS"
gene 3059262..3059786
/gene="argA"
/locus_tag="Rv2747"
CDS 3059262..3059786
/codon_start=1
/transl_table=11
/gene="argA"
/locus_tag="Rv2747"
/product="Probable L-glutamate alpha-N-acetyltranferase
ArgA (alpha-N-acetylglutamate synthase)"
/note="Rv2747, (MTV002.12), len: 174 aa. Probable
argA,alpha-N-acetylglutamate synthase (See Errey et al.,
2005). Contains GNAT (Gcn5-related N-acetyltransferase)
domain. See Vetting et al. 2005. Equivalent to
O05559|ML0978|MLCB33.08 putative acetyltransferase from
Mycobacterium leprae (180 aa), FASTA scores: opt: 997,
E(): 1.2e-57, (86.8% identity in 174 aa overlap). Also
similar to various transferases e.g. Q9X8N2|SCE94.27c
putative acetyltransferase from Streptomyces coelicolor
(169 aa),FASTA scores: opt: 656, E(): 1.3e-35, (60.35%
identity in 164 aa overlap); C-terminus of Q9K3D6|ARGH(A)
argininosuccinase and N-acetylglutamate synthase from
Moritella sp. 2693 (629 aa), FASTA scores: opt: 243, E():
2e-08, (31.95% identity in 144 aa overlap); C-terminus of
Q9JW21|ARGA or NMA0580 putative acetylglutamate synthase
from Neisseria meningitidis serogroup a (436 aa), FASTA
scores: opt: 201, E(): 7.8e-06, (32.75% identity in 119 aa
overlap); etc. Also similar to hypothetical proteins e.g.
O67372|AQ_1359 hypothetical 21.1 KDA protein from Aquifex
aeolicus (181 aa), FASTA scores: opt: 348, E():
1.2e-15,(42.35% identity in 137 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2747"
/db_xref="EnsemblGenomes-Tr:CCP45546"
/db_xref="GOA:O33289"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR010167"
/db_xref="InterPro:IPR016181"
/db_xref="PDB:5YGE"
/db_xref="PDB:5YO2"
/db_xref="PDB:6ADD"
/db_xref="UniProtKB/Swiss-Prot:O33289"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45546.1"
/translation="MTERPRDCRPVVRRARTSDVPAIKQLVDTYAGKILLEKNLVTLY
EAVQEFWVAEHPDLYGKVVGCGALHVLWSDLGEIRTVAVDPAMTGHGIGHAIVDRLLQ
VARDLQLQRVFVLTFETEFFARHGFTEIEGTPVTAEVFDEMCRSYDIGVAEFLDLSYV
KPNILGNSRMLLVL"
gene complement(3059855..3062506)
/gene="ftsK"
/locus_tag="Rv2748c"
CDS complement(3059855..3062506)
/codon_start=1
/transl_table=11
/gene="ftsK"
/locus_tag="Rv2748c"
/product="Possible cell division transmembrane protein
FtsK"
/note="Rv2748c, (MTV002.13c), len: 883 aa. Possible
ftsK,cell division transmembrane protein, equivalent to
O05560|ML0977|FTSK|MLCB33.09c cell division protein from
Mycobacterium leprae (886 aa), FASTA scores: opt:
3147,E(): 7.9e-175, (78.1% identity in 885 aa overlap).
Also similar to other members of the spoIIIE/ftsK family
e.g. O86810|SC7C7.05 FTSK homolog from Streptomyces
coelicolor (929 aa), FASTA scores: opt: 2256, E():
3.8e-123, (49.05% identity in 924 aa overlap); Q9CF25|FTSK
cell division protein FTSK from Lactococcus lactis (subsp.
lactis) (Streptococcus lactis) (763 aa), FASTA scores:
opt: 1438,E(): 9.1e-76, (37.7% identity in 751 aa
overlap); AAK75005|Q97RE4|SP0878 SPOE family protein from
Streptococcus pneumoniae (767 aa), FASTA scores: opt:
1405,E(): 7.5e-74, (48.0% identity in 477 aa overlap);
P46889|FTSK_ECOLI|B0890 from Escherichia coli strain K12
(1329 aa), FASTA scores: opt: 759, E(): 0, (44.5% identity
in 537 aa overlap) (similarity in C-terminal half); etc.
Equivalent to AAK47139 from Mycobacterium tuberculosis
strain CDC1551 (968 aa) but shorter 85 aa. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the FTSK/SPOIIIE family."
/db_xref="EnsemblGenomes-Gn:Rv2748c"
/db_xref="EnsemblGenomes-Tr:CCP45547"
/db_xref="GOA:P9WNA3"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR018541"
/db_xref="InterPro:IPR025199"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR041027"
/db_xref="UniProtKB/Swiss-Prot:P9WNA3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45547.1"
/translation="MLGPPGTPRVGRRDAARSLVTLLRRPWQRGEQIAVTSVADGVDG
VIATRLAVMSSKTVARSGTRTSRSKATSRGASRSARSAVPRKRSRPVKGVGRPSRRHH
RSLLVSTGLACGRAMRAVWMMAAKGTGGAARSIGRARDIEPGHRRDGIALVLLGLAVV
VAASSWFDAARPLGAWVDALLRTFIGSAVVMLPLVAAAVAVVLMRTSPNPDSRPRLIL
GASLIGLSFLGLCHLWAGSPEAPESRLRAAGFIGFAIGGPLSDGLTAWIAAPLLFIGA
LFGLLLLAGITIREVPDAMRAMFGTRLLPREYADDFEDFADFDGDDADTVEVARQDFS
DGYYDEVPLCSDDGPPAWPSAEVPQDDTATIPEASAGRGSGRRGRRKDTQVLDRIVEG
PYTLPSLDLLISGDPPKKRSAANTHMAGAIGEVLTQFKVDAAVTGCTRGPTVTRYEVE
LGPGVKVEKITALQRNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREMVRLADVLTA
RETRRDHHPLVIGLGKDIEGDFISANLAKMPHLLVAGSTGSGKSSFVNSMLVSLLTRA
TPEEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVDEMEQRYQDMQAS
RVRHIDDFNDKVRSGAITAPLGSQREYRPYPYVVAIVDELADLMMTAPRDVEDAIVRI
TQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLI
GMGDGLFLPMGASKPLRLQGAYVSDEEIHAVVTACKEQAEPEYTEGVTTAKPTAERTD
VDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRGIVGPSE
GSKAREVLVKPDELAGTLAAIRGDGGE"
gene 3062505..3062819
/locus_tag="Rv2749"
CDS 3062505..3062819
/codon_start=1
/transl_table=11
/locus_tag="Rv2749"
/product="Conserved protein"
/note="Rv2749, (MTV002.14), len: 104 aa. Conserved
protein,showing some similarity with Q9I1R9|PA2198
hypothetical protein from Pseudomonas aeruginosa (114 aa),
FASTA scores: opt: 157, E(): 0.00081, (35.0% identity in
100 aa overlap); and O86332|Rv0793|MTV042.03 hypothetical
11.2 KDA protein from Mycobacterium tuberculosis (101 aa),
FASTA scores: opt: 143, E(): 0.0062, (26.9% identity in 93
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2749"
/db_xref="EnsemblGenomes-Tr:CCP45548"
/db_xref="InterPro:IPR007138"
/db_xref="InterPro:IPR011008"
/db_xref="UniProtKB/TrEMBL:O33291"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45548.1"
/translation="MPVVVVATLTAKPESVDTVRDILTRAVDDVHREPGCQLYALHET
GETFIFVEQWADAEALKAHSGAPAVATMFTAAGEHLVGAPDIKLLQPVPAGDPSKGQL
RR"
gene 3062816..3063634
/locus_tag="Rv2750"
CDS 3062816..3063634
/codon_start=1
/transl_table=11
/locus_tag="Rv2750"
/product="Probable dehydrogenase"
/note="Rv2750, (MTV002.15), len: 272 aa. Probable
dehydrogenase, highly similar to other
dehydrogenases/reductases e.g. Q9L5X5|cox cholesterol
oxidase from Nocardioides simplex (Arthrobacter simplex)
(270 aa), FASTA scores: opt: 836, E(): 1.8e-43, (55.7%
identity in 264 aa overlap); Q9RA05|LIMC carveol
dehydrogenase from Rhodococcus erythropolis (277 aa),
FASTA scores: opt: 792, E(): 8.6e-41, (48.55% identity in
274 aa overlap); Q9F5J1|SIM-NJ1|SIMD2 putative
3-keto-acyl-reductase from Streptomyces antibioticus (273
aa), FASTA scores: opt: 435, E(): 3.7e-19, (35.75%
identity in 263 aa overlap); etc. Also highly similar to
AAK44941MT0715 oxidoreductase (short-chain
dehydrogenase/reductase family) from Mycobacterium
tuberculosis strain CDC1551 (275 aa), FASTA scores: opt:
702, E(): 2.4e-35, (44.45% identity in 270 aa overlap);
and similar to many other Mycobacterium tuberculosis
dehydrogenases."
/db_xref="EnsemblGenomes-Gn:Rv2750"
/db_xref="EnsemblGenomes-Tr:CCP45549"
/db_xref="GOA:P9WGS5"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR023985"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGS5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45549.1"
/translation="MIDRPLEGKVAFITGAARGLGRAHAVRLAADGANIIAVDICEQI
ASVPYPLSTADDLAATVELVEDAGGGIVARQGDVRDRASLSVALQAGLDEFGRLDIVV
ANAGIAMMQAGDDGWRDVIDVNLTGVFHTVQVAIPTLIEQGTGGSIVLISSAAGLVGI
GSSDPGSLGYAAAKHGVVGLMRAYANHLAPQNIRVNSVHPCGVDTPMINNEFFQQWLT
TADMDAPHNLGNALPVELVQPTDIANAVAWLASEEARYVTGVTLPVDAGFVNKR"
gene 3063638..3064528
/locus_tag="Rv2751"
CDS 3063638..3064528
/codon_start=1
/transl_table=11
/locus_tag="Rv2751"
/product="Conserved protein"
/note="Rv2751, (MTV002.16), len: 296 aa. Conserved
protein,similar in part to others e.g. Q98LR1|MLR0915
hypothetical protein from Rhizobium loti (Mesorhizobium
loti) (299 aa),FASTA scores: opt: 279, E(): 1.6e-11,
(32.85% identity in 210 aa overlap); Q9FBX1|SC8E7.10
conserved hypothetical protein from Streptomyces
coelicolor (283 aa), FASTA scores: opt: 232, E(): 2.4e-08,
(27.9% identity in 269 aa overlap); Q9FMY9 hypothetical
protein (genomic DNA,chromosome 5, P1 clone:MJB21) from
Arabidopsis thaliana (Mouse-ear cress) (370 aa), FASTA
scores: opt: 205, E(): 2.1e-06, (28.9% identity in 211 aa
overlap); etc. Also similar in part to several proteins
from Mycobacterium tuberculosis:
P72053|Rv3787c|MTCY13D12.21 hypothetical 33.4 KDA protein
(308 aa), FASTA scores: opt: 266, E(): 1.3e-10,(29.6%
identity in 267 aa overlap);
O53795|MBE50c|Rv0731c|MTV041.05c hypothetical 34.9 KDA
protein (318 aa), FASTA scores: opt: 266, E():
1.3e-10,(32.05% identity in 281 aa overlap);
O53841|Rv0830|MTV043.22 hypothetical 33.4 KDA protein (301
aa), FASTA scores: opt: 263, E(): 2e-10, (31.3% identity
in 262 aa overlap); etc. Belongs to the MTCY13D12.21 /
MTCY210.45C / MTCY78.29C family."
/db_xref="EnsemblGenomes-Gn:Rv2751"
/db_xref="EnsemblGenomes-Tr:CCP45550"
/db_xref="GOA:I6YEA3"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:I6YEA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45550.1"
/translation="MARNPAAQTAFGPMVLAAVEQNEPPGRRLVDDDLADLFLPRPLR
WLAGATRSAVLRRLLISASEWSGRGLWANLACRKRFIGDKLDEALGDIDAVVILGAGL
DTRAYRLTRRVRMPVFEVDLPVNIARKAKTVRRVLGELPLSVRLVALDFEHDDLLTAL
AEHGYRTEYRVFFVCEGVTQYLTERAVRRTLEGLRAAAPGSRMVFTYVRRDFIDGTNR
YGTRTLYHTVRQRRQLWHFGLDPEEVAGFLADYGWRLTEQAGPEELVQRYVEPTGRNL
NASQIEWSAYAEKSEPVTPR"
gene complement(3064515..3066191)
/locus_tag="Rv2752c"
CDS complement(3064515..3066191)
/codon_start=1
/transl_table=11
/locus_tag="Rv2752c"
/product="Conserved hypothetical protein"
/note="Rv2752c, (MTV002.17c), len: 558 aa. Conserved
hypothetical protein, equivalent to Q9CBW5|ML1512
hypothetical protein from Mycobacterium leprae (558
aa),FASTA scores: opt: 3301, E(): 1.2e-195, (89.05%
identity in 558 aa overlap). Also highly similar to other
hypothetical proteins from a wide range of prokaryotes
e.g. CAC19480|P54122|YOR4_CORGL from Corynebacterium
glutamicum (Brevibacterium flavum) (718 aa), FASTA scores:
opt: 2142,E(): 3.5e-124, (57.2% identity in 554 aa
overlap) (N-terminus longer); O86842|SC9A10.09 from
Streptomyces coelicolor (561 aa), FASTA scores: opt: 2077,
E(): 2.9e-120, (55.95% identity in 556 aa overlap); Q9ZI80
from Streptomyces toyocaensis (528 aa), FASTA scores: opt:
1843,E(): 7.3e-106, (52.45% identity in 528 aa overlap)
(N-terminus shorter 30 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv2752c"
/db_xref="EnsemblGenomes-Tr:CCP45551"
/db_xref="GOA:P9WGZ9"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR004613"
/db_xref="InterPro:IPR011108"
/db_xref="InterPro:IPR030854"
/db_xref="InterPro:IPR036866"
/db_xref="InterPro:IPR041636"
/db_xref="InterPro:IPR042173"
/db_xref="UniProtKB/Swiss-Prot:P9WGZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45551.1"
/translation="MDVDLPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIID
CGVLFPGHDEPGVDLILPDMRHVEDRLDDIEALVLTHGHEDHIGAIPFLLKLRPDIPV
VGSKFTLALVAEKCREYRITPVFVEVREGQSTRHGVFECEYFAVNHSTPDALAIAVYT
GAGTILHTGDIKFDQLPPDGRPTDLPGMSRLGDTGVDLLLCDSTNAEIPGVGPSESEV
GPTLHRLIRGADGRVIVACFASNVDRVQQIIDAAVALGRRVSFVGRSMVRNMRVARQL
GFLRVADSDLIDIAAAETMAPDQVVLITTGTQGEPMSALSRMSRGEHRSITLTAGDLI
VLSSSLIPGNEEAVFGVIDALSKIGARVVTNAQARVHVSGHAYAGELLFLYNGVRPRN
VMPVHGTWRMLRANAKLAASTGVPQESILLAENGVSVDLVAGKASISGAVPVGKMFVD
GLIAGDVGDITLGERLILSSGFVAVTVVVRRGTGQPLAAPHLHSRGFSEDPKALEPAV
RKVEAELESLVAANVTDPIRIAQGVRRTVGKWVGETYRRQPMIVPTVIEV"
gene complement(3066222..3067124)
/gene="dapA"
/locus_tag="Rv2753c"
CDS complement(3066222..3067124)
/codon_start=1
/transl_table=11
/gene="dapA"
/locus_tag="Rv2753c"
/product="Probable dihydrodipicolinate synthase DapA
(DHDPS) (dihydrodipicolinate synthetase)"
/note="Rv2753c, (MT2823, MTV002.18c), len: 300 aa.
Probable dapA, dihydrodipicolinate synthase, equivalent to
Q9CBW4|DAPA_MYCLE|ML1513 dihydrodipicolinate synthase from
Mycobacterium leprae (300 aa), FASTA scores: opt:
1699,E(): 2.2e-98, (86.65% identity in 300 aa overlap).
Also highly similar to many e.g. P19808|DAPA_CORGL from
Corynebacterium glutamicum (Brevibacterium flavum) (301
aa), FASTA scores: opt: 1089, E(): 2e-60, (58.7% identity
in 288 aa overlap); O86841|DAPA_STRCO|SC9A10.08 from
Streptomyces coelicolor (299 aa), FASTA scores: opt:
1044,E(): 1.3e-57, (55.75% identity in 287 aa overlap);
P05640|DAPA_ECOLI (292 aa), FASTA scores: opt: 515, E():
0,(33.8% identity in 287 aa overlap); etc. Contains
PS00665 and PS00666 Dihydrodipicolinate synthetase
signatures 1 and 2. Belongs to the DHDPS family."
/db_xref="EnsemblGenomes-Gn:Rv2753c"
/db_xref="EnsemblGenomes-Tr:CCP45552"
/db_xref="GOA:P9WP25"
/db_xref="InterPro:IPR002220"
/db_xref="InterPro:IPR005263"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR020624"
/db_xref="InterPro:IPR020625"
/db_xref="PDB:1XXX"
/db_xref="PDB:3L21"
/db_xref="PDB:5J5D"
/db_xref="UniProtKB/Swiss-Prot:P9WP25"
/inference="protein motif:PROSITE:PS00666"
/inference="protein motif:PROSITE:PS00665"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45552.1"
/translation="MTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQ
GCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRLAKAC
AAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA
LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLA
AGQLRELLSAFGSGDIATARKINIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRL
PQVAATPEQIDALAADMRAASVLR"
gene complement(3067193..3067945)
/gene="thyX"
/locus_tag="Rv2754c"
CDS complement(3067193..3067945)
/codon_start=1
/transl_table=11
/gene="thyX"
/locus_tag="Rv2754c"
/product="Probable thymidylate synthase ThyX (ts) (TSase)"
/note="Rv2754c, (MTV002.19c), len: 250 aa. Probable
thyX,thymidylate synthase, highly similar to
Q9CBW3|YF14_MYCLE|ML1514 thymidylate synthase from
Mycobacterium leprae (254 aa), FASTA scores: opt:
1351,E(): 1e-84, (81.5% identity in 254 aa overlap). Also
highly similar to several others e.g P40111|THYX_CORGL
from Corynebacterium glutamicum (Brevibacterium flavum)
(250 aa), FASTA scores: opt: 1080, E(): 9.8e-67, (62.85%
identity in 245 aa overlap); Q05259|THYX_BPML5 Probable
thymidylate synthase from Mycobacteriophage L5 (243
aa),FASTA scores: opt: 610, E(): 3.2e-34, (49.55% identity
in 220 aa overlap); etc. Contains Pfam match to entry
PF02511 Thymidylate synthase complementing protein.
Belongs to the THY1 family."
/db_xref="EnsemblGenomes-Gn:Rv2754c"
/db_xref="EnsemblGenomes-Tr:CCP45553"
/db_xref="GOA:P9WG57"
/db_xref="InterPro:IPR003669"
/db_xref="InterPro:IPR036098"
/db_xref="PDB:2AF6"
/db_xref="PDB:2GQ2"
/db_xref="PDB:3GWC"
/db_xref="PDB:3HZG"
/db_xref="UniProtKB/Swiss-Prot:P9WG57"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45553.1"
/translation="MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACY
QSWSKPNPKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYS
QLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNA
ILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQ
LAAVAPAVFADFEVTTLADGTEVATSPLATEA"
gene complement(3068189..3068464)
/gene="hsdS.1"
/gene_synonym="hsdS'"
/locus_tag="Rv2755c"
CDS complement(3068189..3068464)
/codon_start=1
/transl_table=11
/gene="hsdS.1"
/gene_synonym="hsdS'"
/locus_tag="Rv2755c"
/product="Possible type I restriction/modification system
specificity determinant (fragment) HsdS.1 (S protein)"
/note="Rv2755c, (MTV002.20c), len: 91 aa. Possible
hsdS.1,fragment of type I restriction/modification system
specificity determinant (S protein), similar to the
N-terminus of other hsdS proteins e.g. O34140|HSDS from
Klebsiella pneumoniae (439 aa), FASTA scores: opt:
303,E(): 2.1e-13, (46.65% identity in 90 aa overlap);
P72419|sty|SBLI from Salmonella typhimurium (434 aa),
FASTA scores: opt: 278, E(): 1.1e-11, (47.65% identity in
86 aa overlap); and Q9P9X9|XF2741 from Xylella fastidiosa
(412 aa), FASTA scores: opt: 144, E(): 0.015, (31.7%
identity in 82 aa overlap). Also some similarity with
O33303|Rv2761c|MTV002.26c|HSDS possible type I
restriction/modification system specificity determinant
from Mycobacterium tuberculosis (364 aa), FASTA scores:
opt: 145, E(): 0.012, (29.9% identity in 87 aa overlap).
Note that previously known as hsdS'."
/db_xref="EnsemblGenomes-Gn:Rv2755c"
/db_xref="EnsemblGenomes-Tr:CCP45554"
/db_xref="UniProtKB/TrEMBL:I6XF84"
/protein_id="CCP45554.1"
/translation="MSDGWKTLRFGEVLELQRGHDLPAASRGSGTVPVIGSFGVTGMH
DTAAYDGPGVAIGRSGAAIGTATFVAGPIWPLDTCLFVRDFKGNDPR"
gene complement(3068461..3070083)
/gene="hsdM"
/locus_tag="Rv2756c"
CDS complement(3068461..3070083)
/codon_start=1
/transl_table=11
/gene="hsdM"
/locus_tag="Rv2756c"
/product="Possible type I restriction/modification system
DNA methylase HsdM (M protein) (DNA methyltransferase)"
/note="Rv2756c, (MTV002.21c), len: 540 aa. Possible
hsdM,type I restriction/modification system DNA methylase
(M protein), highly similar to others e.g. Q9P9X8|XF2742
from Xylella fastidiosa (519 aa), FASTA scores: opt: 1613,
E(): 1.9e-96, (52.3% identity in 543 aa overlap);
O34139|HSDM from Klebsiella pneumoniae (539 aa), FASTA
scores: opt: 1267, E(): 4.4e-74, (45.9% identity in 549 aa
overlap); P72418|sty|SBLI|HSDM from Salmonella typhimurium
(539 aa),FASTA scores: opt: 1263, E(): 8e-74, (45.7%
identity in 549 aa overlap); etc. Possible alternative
start site (GTG) overlapping with termination codon of
previous ORF 90 bp upstream. Note that the corresponding
endonuclease (M protein) does not appear to be present in
Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv2756c"
/db_xref="EnsemblGenomes-Tr:CCP45555"
/db_xref="GOA:O33298"
/db_xref="InterPro:IPR003356"
/db_xref="InterPro:IPR022749"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR038333"
/db_xref="UniProtKB/TrEMBL:O33298"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45555.1"
/translation="MPPRKKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILG
LVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVVPVSARWKF
LAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGGTLPRLYNKDNIDQRRLGEL
IDLFNSARFSRQGEHRARDLMGEVYEYFLGNFARAEGKRGGEFFTPPSVVKVIVEVLE
PSSGRVYDPCCGSGGMFVQTEKFIYEHDGDPKDVSIYGQESIEETWRMAKMNLAIHGI
DNKGLGARWSDTFARDQHPDVQMDYVMANLPFNIKDWARNEEDPRWRFGVPPANNANY
AWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRAQIVEADLVSCMVALPTQLFRS
TGIPVCLWFFAKDKAAGKQGSIDRCGQVLFIDARELGDLVDRAERALTNEEIVRIGDT
FHAWRGSKSAAVKGIMYEDVPGFCKSATLAEIKATDYALTPGRYVGTPAVEDDGEPID
EKMARLSKALLEAFDESARLERVVREQLGRLR"
gene complement(3070170..3070586)
/gene="vapC21"
/locus_tag="Rv2757c"
CDS complement(3070170..3070586)
/codon_start=1
/transl_table=11
/gene="vapC21"
/locus_tag="Rv2757c"
/product="Possible toxin VapC21"
/note="Rv2757c, (MTV002.22c), len: 138 aa. Possible
vapC21,toxin, part of toxin-antitoxin (TA) operon with
Rv2758c,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to several others in M.
tuberculosis e.g. P96411|Rv0229c| MTCY08D5.24c (226 aa),
FASTA scores: opt: 354, E(): 4.6e-18, (45.25% identity in
137 aa overlap) (N-terminus longer 89 aa);
P95007|RV2546|MTCY159.10c (137 aa), FASTA scores: opt:
265, E(): 7.5e-12, (38.5% identity in 135 aa overlap);
O07228|Rv0301|MTCY63.06 (141 aa), FASTA scores: opt: 259,
E(): 2.1e-11, (42.4% identity in 132 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2757c"
/db_xref="EnsemblGenomes-Tr:CCP45556"
/db_xref="GOA:P9WF91"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="PDB:5SV2"
/db_xref="UniProtKB/Swiss-Prot:P9WF91"
/protein_id="CCP45556.1"
/translation="MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFG
VSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEIQEALTDKGFHRSVKIPDLIIAA
VAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA"
gene complement(3070583..3070849)
/gene="vapB21"
/locus_tag="Rv2758c"
CDS complement(3070583..3070849)
/codon_start=1
/transl_table=11
/gene="vapB21"
/locus_tag="Rv2758c"
/product="Possible antitoxin VapB21"
/note="Rv2758c, (MTV002.23c), len: 88 aa. Possible
vapB21,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2757c (See Arcus et al., 2005; Pandey and Gerdes, 2005).
Similar to several others in M. tuberculosis e.g.
P95008|Rv2545 (92 aa), FASTA scores: opt: 151, E():
0.00028, (66.65% identity in 45 aa overlap);
Q10771|YF60_MYCTU|RV1560|MT1611|MTCY48.05c (72 aa), FASTA
scores: opt: 106, E(): 0.52, (39.15% identity in 46 aa
overlap); O06565|Rv1113|MTCY22G8.02 (65 aa), FASTA scores:
opt: 97, E(): 2.2, (33.35% identity in 69 aa overlap);
etc. Contains PS00402 Binding-protein-dependent transport
systems inner membrane comp signature."
/db_xref="EnsemblGenomes-Gn:Rv2758c"
/db_xref="EnsemblGenomes-Tr:CCP45557"
/db_xref="GOA:P9WJ43"
/db_xref="InterPro:IPR019239"
/db_xref="UniProtKB/Swiss-Prot:P9WJ43"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP45557.1"
/translation="MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHA
ALRAALRASAARSLMNRMAENATGTQDEALVNAMWRDGHPENTA"
gene complement(3070875..3071270)
/gene="vapC42"
/locus_tag="Rv2759c"
CDS complement(3070875..3071270)
/codon_start=1
/transl_table=11
/gene="vapC42"
/locus_tag="Rv2759c"
/product="Possible toxin VapC42. Contains PIN domain."
/note="Rv2759c, (MTV002.24c), len: 131 aa. Possible
vapC42,toxin, part of toxin-antitoxin (TA) operon with
Rv2760c,contains PIN domain, see Arcus et al. 2005.
Similar to others in M. tuberculosis e.g.
O07769|Y609_MYCTU|Rv0609|MT0638|MTCY19H5.13c (133
aa),FASTA scores: opt: 364, E(): 5.1e-18, (49.6% identity
in 131 aa overlap);
P96914|Y624_MYCTU|Rv0624|MT0652|MTCY20H10.05 (131
aa),FASTA scores: opt: 324, E(): 2.9e-15, (42.85% identity
in 126 aa overlap); and
Q10874|YJ82_MYCTU|Rv1982c|MT2034|MTCY39.37 (139 aa), FASTA
scores: opt: 271, E(): 1.4e-11, (38.6% identity in 127 aa
overlap). Also similar to other hypothetical proteins from
other bacteria e.g. CAC45376|SMC00900 conserved
hypothetical protein from Rhizobium meliloti
(Sinorhizobium meliloti) (128 aa), FASTA scores: opt: 286,
E(): 1.2e-12,(39.55% identity in 129 aa overlap);
Q981I7|MLL9357 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (131 aa), FASTA scores: opt: 257,
E(): 1.2e-10,(36.35% identity in 132 aa overlap);
Q9AAG1|CC0639 hypothetical protein from Caulobacter
crescentus (131 aa),FASTA scores: opt: 217, E(): 6.9e-08,
(33.35% identity in 132 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2759c"
/db_xref="EnsemblGenomes-Tr:CCP45558"
/db_xref="GOA:P9WF57"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF57"
/protein_id="CCP45558.1"
/translation="MIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAI
MQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAAQAYRDYGRGSGHPARLNLGDTY
SYALAQVTGEPLLFRGDDFTHTDIRPACT"
gene complement(3071267..3071536)
/gene="vapB42"
/locus_tag="Rv2760c"
CDS complement(3071267..3071536)
/codon_start=1
/transl_table=11
/gene="vapB42"
/locus_tag="Rv2760c"
/product="Possible antitoxin VapB42"
/note="Rv2760c, (MTV002.25c), len: 89 aa. Possible
vapB42,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2759c, see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis e.g. O07770|Rv0608|MTCY19H5.14c
(81 aa), FASTA scores: opt: 128, E(): 0.057, (37.5%
identity in 88 aa overlap); and P96913|Rv0623|MTCY20H10.04
(84 aa), FASTA scores: opt: 99, E(): 5.5, (37.1% identity
in 89 aa overlap). Also showing some similarity with
CAC45377|SMC00899 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) (84 aa), FASTA
scores: opt: 116, E(): 0.38, (36.25% identity in 91 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2760c"
/db_xref="EnsemblGenomes-Tr:CCP45559"
/db_xref="InterPro:IPR011660"
/db_xref="UniProtKB/Swiss-Prot:P9WJ19"
/protein_id="CCP45559.1"
/translation="MSLNIKSQRTVALVRELAARTGTNQTAAVEDAVARRLSELDRED
RARAEARRAAAEQTLRDLDKLLSDDDKRLIRRHEVDLYDDSGLPR"
gene complement(3071546..3072640)
/gene="hsdS"
/locus_tag="Rv2761c"
CDS complement(3071546..3072640)
/codon_start=1
/transl_table=11
/gene="hsdS"
/locus_tag="Rv2761c"
/product="Possible type I restriction/modification system
specificity determinant HsdS (S protein)"
/note="Rv2761c, (MTV002.26c), len: 364 aa. Possible
hsdS,type I restriction/modification system specificity
determinant (S protein), similar in part to other hsdS
protein (S proteins) e.g. Q9P9X9|XF2741 from Xylella
fastidiosa (412 aa), FASTA scores: opt: 252, E():
7.4e-09,(24.95% identity in 401 aa overlap); N-terminus of
Q9RC12 type I S-subunit from Lactobacillus delbrueckii
(subsp. lactis) (389 aa), FASTA scores: opt: 232, E():
1.4e-07,(28.1% identity in 185 aa overlap); N-terminus of
P72419|sty|SBLI from Salmonella typhimurium (434 aa),
FASTA scores: opt: 221, E(): 8e-07, (28.45% identity in
130 aa overlap); C-terminus of P17222|PRRB_ECOLI from
Escherichia coli strain CTR5X (401 aa), FASTA scores: opt:
197, E(): 2.8e-05, (27.05% identity in 148 aa overlap);
etc. Seems to belong to type-I restriction system S
methylase family."
/db_xref="EnsemblGenomes-Gn:Rv2761c"
/db_xref="EnsemblGenomes-Tr:CCP45560"
/db_xref="GOA:I6YEB1"
/db_xref="InterPro:IPR000055"
/db_xref="UniProtKB/TrEMBL:I6YEB1"
/protein_id="CCP45560.1"
/translation="MSRVEKVEKVRLGDHLDFSNGHTSGHTSPASEPGGRYPVYGANG
VIGYSAQHNARGPLIVVGRVGSYCGSLRYCDSDVWVTDNALACRAKKPEETRYWYYAL
LGFGLNRYRAGSGQPLLSQGVLRNVSVSAVAAPDRPRIGEILGAFDDKIAANDRVIEA
AEALMLAIVGRLSAYVPLSSLASRSTACLDAQHFDSTVAHYSFAAFDGGAQPSRVGGR
TIRSAKLVVSQPCVLFPKLNPRIPRIWNITSLPSEMALASTEFVVLRPVGVDTSALWA
ALRQPDVLAELRQLVGGMTGSRQRIQPTQLLRVWVRDVRRLTPGHAAAIANLGALCNE
RRIESARLASCRDALLPLLMSGIDGLPAGR"
gene complement(3072637..3073056)
/locus_tag="Rv2762c"
CDS complement(3072637..3073056)
/codon_start=1
/transl_table=11
/locus_tag="Rv2762c"
/product="Conserved hypothetical protein"
/note="Rv2762c, (MTV002.27c), len: 139 aa. Conserved
hypothetical protein, similar to C-terminus of
hypothetical proteins: Q9A380|CC3324 from Caulobacter
crescentus (409 aa), FASTA scores: opt: 181, E(): 9.8e-05,
(43.55% identity in 101 aa overlap); Q98KQ4|MLR1373 from
Rhizobium loti (Mesorhizobium loti) (399 aa), FASTA
scores: opt: 174, E(): 0.00028, (46.35% identity in 82 aa
overlap); and Q9HZZ9|PA2844 from Pseudomonas aeruginosa
(402 aa), FASTA scores: opt: 158, E(): 0.0033, (40.0%
identity in 80 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2762c"
/db_xref="EnsemblGenomes-Tr:CCP45561"
/db_xref="UniProtKB/TrEMBL:I6X5B0"
/protein_id="CCP45561.1"
/translation="MSAATAAWDRRAAVVVGGVAEPGSAGPIAGADRKRLISRIQVRQ
LDSAAVAAKRRHLYYVRPLDGHPVARVDRKTDRAADSLPVAGVLGELDIPPVTVAEGL
AGELASMASWLGLGGIAVSTRGDLAGELCAATKRTNG"
repeat_region 3073055..3073112
/note="51 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene complement(3073130..3073609)
/gene="dfrA"
/gene_synonym="folA"
/locus_tag="Rv2763c"
CDS complement(3073130..3073609)
/codon_start=1
/transl_table=11
/gene="dfrA"
/gene_synonym="folA"
/locus_tag="Rv2763c"
/product="Dihydrofolate reductase DfrA (DHFR)
(tetrahydrofolate dehydrogenase)"
/note="Rv2763c, (MTV002.28c), len: 159 aa. Probable dfrA
(alternate gene names: folA, dhfr), dihydrofolate
reductase, equivalent to O30463|FOLA dihydrofolate
reductase from Mycobacterium avium (see citation below)
(181 aa), FASTA scores: opt: 802, E(): 4.5e-48, (70.2%
identity in 161 aa overlap); and Q9CBW1|FOLA|ML1518
dihydrofolate reductase from Mycobacterium leprae (165
aa),FASTA scores: opt: 782, E(): 1e-46, (70.55% identity
in 163 aa overlap). Also highly similar to many e.g.
Q9K168|DYR_NEIMB|FOLA|NMB0308 from Neisseria meningitidis
(serogroup B) (162 aa), FASTA scores: opt: 469, E():
3.8e-25, (46.65% identity in 163 aa overlap);
P12833|DYR3_SALTY|DHFRIII from Salmonella typhimurium (162
aa), FASTA scores: opt: 367, E(): 4e-18, (45.4% identity
in 141 aa overlap); Q59408|DYRC_ECOLI|DHFRXIII from
Escherichia coli strain RA33.2 (165 aa), FASTA scores:
opt: 313, E(): 2.2e-14, (41.9% identity in 136 aa
overlap); etc. Contains PS00075 Dihydrofolate reductase
signature. Belongs to the dihydrofolate reductase family."
/db_xref="EnsemblGenomes-Gn:Rv2763c"
/db_xref="EnsemblGenomes-Tr:CCP45562"
/db_xref="GOA:P9WNX1"
/db_xref="InterPro:IPR001796"
/db_xref="InterPro:IPR012259"
/db_xref="InterPro:IPR017925"
/db_xref="InterPro:IPR024072"
/db_xref="PDB:1DF7"
/db_xref="PDB:1DG5"
/db_xref="PDB:1DG7"
/db_xref="PDB:1DG8"
/db_xref="PDB:2CIG"
/db_xref="PDB:4KL9"
/db_xref="PDB:4KLX"
/db_xref="PDB:4KM0"
/db_xref="PDB:4KM2"
/db_xref="PDB:4KNE"
/db_xref="PDB:4M2X"
/db_xref="PDB:5JA3"
/db_xref="PDB:5U26"
/db_xref="PDB:5U27"
/db_xref="PDB:5UJF"
/db_xref="PDB:6DDP"
/db_xref="PDB:6DDS"
/db_xref="PDB:6DDW"
/db_xref="PDB:6NNC"
/db_xref="PDB:6NND"
/db_xref="PDB:6NNH"
/db_xref="PDB:6NNI"
/db_xref="UniProtKB/Swiss-Prot:P9WNX1"
/inference="protein motif:PROSITE:PS00075"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45562.1"
/translation="MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGR
RTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYAL
ALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS"
gene complement(3073680..3074471)
/gene="thyA"
/locus_tag="Rv2764c"
CDS complement(3073680..3074471)
/codon_start=1
/transl_table=11
/gene="thyA"
/locus_tag="Rv2764c"
/product="Probable thymidylate synthase ThyA (ts) (TSASE)"
/note="Rv2764c, (MTV002.29c), len: 263 aa. Probable
thyA,thymidylate synthase, equivalent to
Q9CBW0|TYSY_MYCLE|THYA|ML1519 thymidylate synthase from
Mycobacterium leprae (266 aa), FASTA scores: opt:
1602,E(): 5.9e-102, (85.5% identity in 262 aa overlap).
Also highly similar to many e.g.
P00470|TYSY_ECOLI|B2827|Z4144|ECS3684|BAB37107|AAG57938
from Escherichia coli strains K12 and O157:H7 (264
aa),FASTA scores: opt: 1309, E(): 5.9e-82, (66.65%
identity in 261 aa overlap); P48464|TYSY_SHIFL|THYA from
Shigella flexneri (264 aa), FASTA scores: opt: 1303, E():
1.5e-81,(65.9% identity in 261 aa overlap);
P54081|TYSB_BACAM|THYB|THYBA from Bacillus
amyloliquefaciens (264 aa), FASTA scores: opt: 1235, E():
6.7e-77, (66.65% identity in 261 aa overlap); etc.
Contains PS00091 Thymidylate synthase active site. Belongs
to the thymidylate synthase family."
/db_xref="EnsemblGenomes-Gn:Rv2764c"
/db_xref="EnsemblGenomes-Tr:CCP45563"
/db_xref="GOA:P9WFR9"
/db_xref="InterPro:IPR000398"
/db_xref="InterPro:IPR020940"
/db_xref="InterPro:IPR023451"
/db_xref="InterPro:IPR036926"
/db_xref="PDB:3QJ7"
/db_xref="PDB:4FOA"
/db_xref="PDB:4FOG"
/db_xref="PDB:4FOX"
/db_xref="PDB:4FQS"
/db_xref="UniProtKB/Swiss-Prot:P9WFR9"
/inference="protein motif:PROSITE:PS00091"
/protein_id="CCP45563.1"
/translation="MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPL
LTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWP
APSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLS
CQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRL
QLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV"
gene 3074636..3075373
/locus_tag="Rv2765"
CDS 3074636..3075373
/codon_start=1
/transl_table=11
/locus_tag="Rv2765"
/product="Probable alanine rich hydrolase"
/note="Rv2765, (MTV002.30), len: 245 aa. Probable ala-rich
hydrolase, similar to various hydrolases or hypothetical
proteins e.g. Q9KYM6|SC9H11.13c putative hydrolase from
Streptomyces coelicolor (251 aa), FASTA scores: opt:
630,E(): 1.4e-33, (43.1% identity in 246 aa overlap);
Q9A5T9|CC2358 dienelactone hydrolase family protein from
Caulobacter crescentus (286 aa), FASTA scores: opt:
592,E(): 4.5e-31, (38.45% identity in 242 aa overlap);
Q9FCF1|2SCD46.33 putative hydrolase (dienelactone
hydrolase family) from Streptomyces coelicolor (254 aa),
FASTA scores: opt: 500, E(): 3.9e-25, (37.7% identity in
252 aa overlap); P73163|DLHH_SYNY3|SLL1298 putative
carboxymethylenebutenolidase (dienelactone hydrolase) from
Synechocystis sp. (strain PCC 6803) (246 aa), FASTA
scores: opt: 276, E(): 1.3e-10, (26.95% identity in 230 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2765"
/db_xref="EnsemblGenomes-Tr:CCP45564"
/db_xref="GOA:I6XF92"
/db_xref="InterPro:IPR002925"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6XF92"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45564.1"
/translation="MPKTTDTAATPDGTCAVRLFTPDGPGRWPGVVMFPDAGGVRDTF
DRMAAKLAGFGYVVLLPDVYYREGDWAPFDMKTAFGDPQERARIMFMIGTLTPDRVTR
DADALLNYLASRPEVIGDRFGVCGYCMGGRMSVVVAGRLPDRVAAAAAFHPGGLVANS
PDSPHLLADRISATVYIGGAENDPSFTADHAEKLDKAFSAAGVPHRIECYPAAHGFAV
PDNPSYDAAADERHWAAMTETFGAALN"
gene complement(3075588..3076370)
/gene_synonym="fabG5"
/locus_tag="Rv2766c"
CDS complement(3075588..3076370)
/codon_start=1
/transl_table=11
/gene_synonym="fabG5"
/locus_tag="Rv2766c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv2766c, (MTV002.31c), len: 260 aa. Probable
short-chain dehydrogenase/reductase , similar to others
(from bacteria and eukaryota) e.g. Q9K3Y8|2SCG61.27c
putative short chain oxidoreductase from Streptomyces
coelicolor (253 aa), FASTA scores: opt: 722, E():
7.4e-39,(44.75% identity in 248 aa overlap);
Q93790|F54F3.4 hypothetical SDR protein from
Caenorhabditis elegans (260 aa), FASTA scores: opt: 613,
E(): 6.9e-32, (41.7% identity in 247 aa overlap);
O95162|O95162|scad-SRL peroxisomal short-chain alcohol
dehydrogenase from Homo sapiens (Human) (260 aa), FASTA
scores: opt: 594, E(): 1.1e-30, (39.6% identity in 250 aa
overlap); P51831|FABG_BACSU 3-oxoacyl-[acyl-carrier
protein] from Bacillus subtilis (246 aa), FASTA scores:
opt: 504, E(): 4e-28, (37.2% identity in 247 aa overlap);
etc. Also similar to many other Mycobacterium tuberculosis
acyl-carrier proteins e.g. MTCY03C7.07 (38.5% identity in
244 aa overlap). Contains PS00061 Short-chain alcohol
dehydrogenase family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family. Note that
previously known as fabG5, a
3-oxoacyl-[acyl-carrier-protein]."
/db_xref="EnsemblGenomes-Gn:Rv2766c"
/db_xref="EnsemblGenomes-Tr:CCP45565"
/db_xref="GOA:I6YEB6"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6YEB6"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45565.1"
/translation="MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVLTARRQEA
ADEAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFGSVDILINNAGTNPAYGPLLEQ
DHARFAKIFDVNLWAPLMWTSLVVTAWMGEHGGAVVNTASIGGMHQSPAMGMYNATKA
ALIHVTKQLALELSPRIRVNAICPGVVRTRLAEALWKDHEDPLAATIALGRIGEPADI
ASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH"
gene complement(3076367..3076720)
/locus_tag="Rv2767c"
CDS complement(3076367..3076720)
/codon_start=1
/transl_table=11
/locus_tag="Rv2767c"
/product="Possible membrane protein"
/note="Rv2767c, (MTV002.32c), len: 117 aa (questionable
ORF). Possible membrane protein, showing very weak
similarity with Q9L2H7|SCC121.09 putative metal transport
ABC transporter from Streptomyces coelicolor (256
aa),FASTA scores: opt: 110, E(): 1, (33.05% identity in
112 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2767c"
/db_xref="EnsemblGenomes-Tr:CCP45566"
/db_xref="GOA:O33309"
/db_xref="UniProtKB/TrEMBL:O33309"
/protein_id="CCP45566.1"
/translation="MVGYEGARGRAGREMSESATAGARSSRIPFGIIRNHEAVRPRRS
RHLNHARDTPQMVAVAQVWREVVQATAIAIAPPLPVVSWGLISLAFLSHTVRGRYRRS
PPAESGHHSNRRQAK"
gene complement(3076894..3078078)
/gene="PPE43"
/locus_tag="Rv2768c"
CDS complement(3076894..3078078)
/codon_start=1
/transl_table=11
/gene="PPE43"
/locus_tag="Rv2768c"
/product="PPE family protein PPE43"
/note="Rv2768c, (MTV002.33c), len: 394 aa. PPE43, Member
of the Mycobacterium tuberculosis PPE family, highly
similar to many e.g. upstream ORF
O33312|Rv2770c|MTV002.35c (402 aa), FASTA scores: opt:
1135, E(): 6.1e-51, (62.15% identity in 391 aa overlap);
and P96362|Rv1039c|MTCY10G2.10 from M. tuberculosis (391
aa), FASTA scores: opt: 1721,E(): 6.8e-81, (70.35%
identity in 398 aa overlap). Equivalent to AAK47157 from
Mycobacterium tuberculosis strain CDC1551 (462 aa) but
shorter 68 aa."
/db_xref="EnsemblGenomes-Gn:Rv2768c"
/db_xref="EnsemblGenomes-Tr:CCP45567"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q79FA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45567.1"
/translation="MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVELSTTASS
VESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAAAQAMASAAAFEAAFA
MTVPPAEVAANRALLAALVATNVLGQNTPAIMATEAHYGEMWAQDALAMYGYAASSAA
AGRLNPLITPSQTANMAGLAGQAAAVSHAAAASTVQQVGLGSLISNLPNAVMGFASPL
TSAADAAGLGGIIQDIEELLGITFVQNAINGAVNTTAWFVMATIPNAVFLGHAFAALN
PATVTAAADAVPAAAAAAGLAHTVTPVGVGGASLTASLGEASSVGGLSVPAGWSTAAP
AMTSGTTALEGSGWAVPEEAGPVAAMPGMAGISGAAKGAGAYAGPRYGFKPIVMPKQV
VV"
gene complement(3078158..3078985)
/gene="PE27"
/locus_tag="Rv2769c"
CDS complement(3078158..3078985)
/codon_start=1
/transl_table=11
/gene="PE27"
/locus_tag="Rv2769c"
/product="PE family protein PE27"
/note="Rv2769c, (MTV002.34c), len: 275 aa. PE27, Member of
the Mycobacterium tuberculosis PE family (see citation
below), highly similar to many (notably in N-terminal
part) e.g. P96361|Rv1040c|MTCY10G2.09 from Mycobacterium
tuberculosis (275 aa), FASTA scores: opt: 1111, E():
5.9e-52, (68.55% identity in 283 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2769c"
/db_xref="EnsemblGenomes-Tr:CCP45568"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR022171"
/db_xref="UniProtKB/TrEMBL:Q79FA8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45568.1"
/translation="MSFLTTQPEELAAAAGKLETIGSAMVAQNAAAAAPTTTGVIPAA
ADEISVLQAPLFTAYGTLYQQVSAEAAAVYDLFVKTLGVSAGTYAATEAANSSAAASP
LSGIASILGSTPGKVPSWISDIANIFNIGAGNWASAASDLLGLASGGLLPAAEEAALE
EGLEGAGLSELGAAEAAVGEAPIAAGLGAAPLAAGLSRASSIGALSVPPSWAGQANLV
SSTSTLQGAGWTTAAPHGAAGTVIPGMPGLASATRSSAGFGAPRYGAKPIVVPKPAV"
gene complement(3079309..3080457)
/gene="PPE44"
/locus_tag="Rv2770c"
CDS complement(3079309..3080457)
/codon_start=1
/transl_table=11
/gene="PPE44"
/locus_tag="Rv2770c"
/product="PPE family protein PPE44"
/note="Rv2770c, (MTV002.35c), len: 382 aa. PPE44, Member
of the Mycobacterium tuberculosis PPE family, highly
similar to many e.g. downstream ORF
O33310|Rv2768c|MTV002.33c from M. tuberculosis (394 aa),
FASTA scores: opt: 1135, E(): 2.2e-53, (62.15% identity in
391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from
Mycobacterium tuberculosis (391 aa), FASTA scores: opt:
1010, E(): 1e-46, (55.95% identity in 395 aa overlap).
Equivalent to AAK47159 from Mycobacterium tuberculosis
strain CDC1551 (402 aa) but shorter 20 aa. Start changed
since first submission (-20 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2770c"
/db_xref="EnsemblGenomes-Tr:CCP45569"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45569.1"
/translation="MDFGALPPEVNSARMYGGAGAADLLAAAAAWNGIAVEVSTAASS
VGSVITRLSTEHWMGPASLSMAAAVQPYLVWLTCTAESSALAAAQAMASAAAFETAFA
LTVPPAEVVANRALLAELTATNILGQNVSAIAATEARYGEMWAQDASAMYGYAAASAV
AARLNPLTRPSHITNPAGLAHQAAAVGQAGASAFARQVGLSHLISDVADAVLSFASPV
MSAADTGLEAVRQFLNLDVPLFVESAFHGLGGVADFATAAIGNMTLLADAMGTVGGAA
PGGGAAAAVAHAVAPAGVGGTALTADLGNASVVGRLSVPASWSTAAPATAAGAALDGT
GWAVPEEDGPIAVMPPAPGMVVAANSVGADSGPRYGVKPIVMPKHGLF"
gene complement(3080581..3081033)
/locus_tag="Rv2771c"
CDS complement(3080581..3081033)
/codon_start=1
/transl_table=11
/locus_tag="Rv2771c"
/product="Conserved hypothetical protein"
/note="Rv2771c, (MTV002.36c), len: 150 aa. Conserved
hypothetical protein, equivalent to Q9CBV8|ML1525
hypothetical protein from Mycobacterium leprae (151
aa),FASTA scores: opt: 489, E(): 1.7e-27, (52.7% identity
in 148 aa overlap). Also highly similar to Q9RD46|SCF56.21
hypothetical 15.7 KDA protein from Streptomyces coelicolor
(151 aa), FASTA scores: opt: 671, E(): 2.2e-40, (67.8%
identity in 146 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2771c"
/db_xref="EnsemblGenomes-Tr:CCP45570"
/db_xref="GOA:O33313"
/db_xref="InterPro:IPR029039"
/db_xref="UniProtKB/TrEMBL:O33313"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45570.1"
/translation="MRRLLIVHHTPSPHMQEMFEAVVSGATDPEIEGVEVVRRPALTV
SPIEMLEADGYLLGTPANLGYISGALKHAFDVCYYLCLDTTRGRSFGAYIHGNEGTEG
AERAVDAITTGLGWVQAAETVVVMGKPSKADIEACWNLGATVAAQLMG"
gene complement(3081119..3081592)
/locus_tag="Rv2772c"
CDS complement(3081119..3081592)
/codon_start=1
/transl_table=11
/locus_tag="Rv2772c"
/product="Probable conserved transmembrane protein"
/note="Rv2772c, (MTV002.37c), len: 157 aa. Probable
conserved transmembrane protein, equivalent to
Q9CBV7|ML1526 conserved membrane protein from
Mycobacterium leprae (160 aa), FASTA scores: opt: 767,
E(): 1.5e-43,(76.6% identity in 154 aa overlap); and
similar to P46830|YDAB_MYCBO from Mycobacterium bovis (177
aa), FASTA scores: opt: 337, E(): 3.9e-15, (40.75%
identity in 135 aa overlap). Also similar to
O86837|SC9A10.04 putative membrane protein from
Streptomyces coelicolor (151 aa),FASTA scores: opt: 338,
E(): 3e-15, (43.75% identity in 144 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2772c"
/db_xref="EnsemblGenomes-Tr:CCP45571"
/db_xref="GOA:I6YA75"
/db_xref="UniProtKB/TrEMBL:I6YA75"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45571.1"
/translation="MTRRTLYVQLIIAFMCVAMVAYLVMLGRVAVAMIGSGRAAAAGL
GLALLILPVIGLWAMIATLRAGFAYQRLARLIAEDGLDIDASALPRRASGRIQRDAAD
ALFAAVRTELEDDADDWRRWYRLARAYDYAGDRRRAREAMKTALQLEGRARPGAR"
gene complement(3081604..3082341)
/gene="dapB"
/locus_tag="Rv2773c"
CDS complement(3081604..3082341)
/codon_start=1
/transl_table=11
/gene="dapB"
/locus_tag="Rv2773c"
/product="Dihydrodipicolinate reductase DapB (DHPR)"
/note="Rv2773c, (MTV002.38c), len: 245 aa.
DapB,dihydrodipicolinate reductase (see Pavelka et al.,
1997),highly similar to many e.g. P40110|DAPB_CORGL from
Corynebacterium glutamicum (Brevibacterium flavum) (248
aa), FASTA scores: opt: 1030, E(): 1.8e-58, (65.45%
identity in 246 aa overlap); O86836|DAPB_STRCO|SC9A10.03
from Streptomyces coelicolor (250 aa), FASTA scores: opt:
997, E(): 2.3e-56, (61.15% identity in 247 aa overlap);
P42976|DAPB_BACSU from Bacillus subtilis (267 aa), FASTA
scores: opt: 608, E(): 1.7e-31, (45.95% identity in 209 aa
overlap); P46829|DAPB_MYCBO from Mycobacterium bovis (see
Cirillo et al., 1994) (271 aa), FASTA scores: opt:
505,E(): 6.3e-25, (36.2% identity in 246 aa overlap); etc.
Belongs to the dihydrodipicolinate reductase family."
/db_xref="EnsemblGenomes-Gn:Rv2773c"
/db_xref="EnsemblGenomes-Tr:CCP45572"
/db_xref="GOA:P9WP23"
/db_xref="InterPro:IPR000846"
/db_xref="InterPro:IPR022663"
/db_xref="InterPro:IPR022664"
/db_xref="InterPro:IPR023940"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:1C3V"
/db_xref="PDB:1P9L"
/db_xref="PDB:1YL5"
/db_xref="PDB:1YL6"
/db_xref="PDB:1YL7"
/db_xref="PDB:5TEK"
/db_xref="PDB:5TJY"
/db_xref="PDB:5TJZ"
/db_xref="PDB:5UGV"
/db_xref="UniProtKB/Swiss-Prot:P9WP23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45572.1"
/translation="MRVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDG
NTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIA
PNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPP
NPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFV
PGVLLAVRRIAERPGLTVGLEPLLDLH"
gene complement(3082352..3082756)
/locus_tag="Rv2774c"
CDS complement(3082352..3082756)
/codon_start=1
/transl_table=11
/locus_tag="Rv2774c"
/product="Hypothetical protein"
/note="Rv2774c, (MTV002.39c), len: 134 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2774c"
/db_xref="EnsemblGenomes-Tr:CCP45573"
/db_xref="UniProtKB/TrEMBL:O33316"
/protein_id="CCP45573.1"
/translation="MGTAVEVGWRDPCGLAVGELRCAPAVSDQPVVGCAGCPLVDMVD
FAPVTGCVAVGSTMGAVPALLRVRFPWPPFEPDVRLSPYLALHGICRWGGSDSCDRTT
VQVFHLHSINKRLTAHAGFGAAAVVGLEDGPV"
gene 3082909..3083370
/locus_tag="Rv2775"
CDS 3082909..3083370
/codon_start=1
/transl_table=11
/locus_tag="Rv2775"
/product="GCN5-related N-acetyltransferase"
/note="Rv2775, (MTV002.40), len: 153 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain. See Vetting et al. 2005.
Showing weak similarity to other hypothetical proteins
e.g. Q9ZBJ7|SC9C7.13c from Streptomyces coelicolor (179
aa),FASTA scores: opt: 167, E(): 0.00024, (29.05% identity
in 148 aa overlap). Equivalent to AAK47164 from
Mycobacterium tuberculosis strain CDC1551 (185 aa) but
shorter 32 aa."
/db_xref="EnsemblGenomes-Gn:Rv2775"
/db_xref="EnsemblGenomes-Tr:CCP45574"
/db_xref="GOA:O33317"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:O33317"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45574.1"
/translation="MHYPVWRQSWTGILDPYLLDMIGSPKLWVEESYPQSLKRGGWSM
WIAESGGQPIGMTMFGPDIAHPDRIQIDALYVAENSQRHGIGGRLLNRALHSHPSADM
ILWCAEKNSKARGFYEKKDFHIDGRTFTWKPLSGVNVPHVGYRLYRSAPPG"
gene complement(3083374..3084303)
/locus_tag="Rv2776c"
CDS complement(3083374..3084303)
/codon_start=1
/transl_table=11
/locus_tag="Rv2776c"
/product="Probable oxidoreductase"
/note="Rv2776c, (MTV002.41c), len: 309 aa. Probable
oxidoreductase, similar to other oxidoreductases e.g.
Q9KZ15|SC10B7.17 putative iron-sulfur oxidoreductase from
Streptomyces coelicolor (364 aa), FASTA scores: opt:
846,E(): 1.2e-45, (46.75% identity in 308 aa overlap);
O88034|SC5A7.28c iron-sulfur oxidoreductase beta subunit
from Streptomyces coelicolor (313 aa), FASTA scores: opt:
745, E(): 2.3e-39, (41.45% identity in 316 aa overlap);
P33164|PDR_BURCE|OPHA1 phthalate dioxygenase reductase
from Burkholderia cepacia (Pseudomonas cepacia) (321 aa),
FASTA scores: opt: 616, E(): 2.9e-31, (33.65% identity in
309 aa overlap); etc. Equivalent to AAK47165 from
Mycobacterium tuberculosis strain CDC1551 (363 aa) but
shorter 54 aa. Contains PS00197 2Fe-2S ferredoxins,
iron-sulfur binding region signature and PS00063 Aldo/keto
reductase family putative active site signature. Seems to
belong to the 2FE2S plant-type ferredoxin family in the
C-terminal section."
/db_xref="EnsemblGenomes-Gn:Rv2776c"
/db_xref="EnsemblGenomes-Tr:CCP45575"
/db_xref="GOA:O86347"
/db_xref="InterPro:IPR000951"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR001433"
/db_xref="InterPro:IPR006058"
/db_xref="InterPro:IPR008333"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR036010"
/db_xref="InterPro:IPR039261"
/db_xref="UniProtKB/TrEMBL:O86347"
/inference="protein motif:PROSITE:PS00197"
/inference="protein motif:PROSITE:PS00063"
/protein_id="CCP45575.1"
/translation="MRRTNPAVVTKRELVAPDVVALTLADPGGGLLPAWSPGGHIDVQ
LPSGRRRQYSLCGVPGRRTDYRIAIRRIADGGGGSIEMHEAFDVGDTCEFEGPRNAFH
LGLAERDVLFVIGGIGVTPILPMIRAAEQRGIDWRAIYAGRGREYMPFLDEVVAVAPG
RVTVWADDEHGRFASVDELLAGAGPTTAVYVCGPPGMLEAVRVARNQHADAPLHYERF
SPPPVVDGVPFELELARSRRVLRVPANRSALDVMLDWDPTTAYSCQQGFCGTCKVRVL
AGQVDRRGRIIEGDNEMLVCVSRAVSGRVVIDA"
gene complement(3084485..3085555)
/locus_tag="Rv2777c"
CDS complement(3084485..3085555)
/codon_start=1
/transl_table=11
/locus_tag="Rv2777c"
/product="Conserved hypothetical protein"
/note="Rv2777c, (MTV002.42c), len: 356 aa. Conserved
hypothetical protein, highly similar (but longer in
N-terminus) to hypothetical proteins Q9KZ16|SC10B7.16 from
Streptomyces coelicolor (296 aa), FASTA scores: opt:
980,E(): 6.8e-57, (51.25% identity in 281 aa overlap); and
Q9HYS0|PA3325 from Pseudomonas aeruginosa (295 aa), FASTA
scores: opt: 816, E(): 4e-46, (43.75% identity in 288 aa
overlap); and similar (but longer in N-terminus) to other
hypothetical proteins e.g. Q9I3H1|PA1542 from Pseudomonas
aeruginosa (278 aa), FASTA scores: opt: 234, E():
6.3e-08,(31.8% identity in 258 aa overlap). Equivalent to
AAK47166 from Mycobacterium tuberculosis strain CDC1551
(393 aa) but shorter 37 aa."
/db_xref="EnsemblGenomes-Gn:Rv2777c"
/db_xref="EnsemblGenomes-Tr:CCP45576"
/db_xref="InterPro:IPR016516"
/db_xref="UniProtKB/TrEMBL:O33319"
/protein_id="CCP45576.1"
/translation="MNVEVHSAPGWRAGSSPLGYAQLYLPTRDVYWGDMSGIYVNAVA
TFSEGAAMVSVDDRATGPHSSESRAADHERLVLEPRDVEFDWTNLPFHYVPNEPMATH
VLNVLHMLLPAGEEFFVRVFKKTLPLIKDDQLRLDVQGFIGQEAMHSQAHSGVVDHFD
AQGVDVTAFTNQIRWLFEKLLGESPRRSPRRQYSWLLEQVSFIAAIEHYTAVMGEWIL
NSPQLDAVGADPVMLDMLRWHGAEEVEHKAVAFDTMKHLRAGYWRQVRAQLTVTPVML
LLWIRGVRFMYSVDPYLPPGTKPRWRDYFKAARRGLVPGLPRLLRVVGHYYKPGFHPS
QLGGLGAAVDYLAVSPAARASH"
gene complement(3085713..3086183)
/locus_tag="Rv2778c"
CDS complement(3085713..3086183)
/codon_start=1
/transl_table=11
/locus_tag="Rv2778c"
/product="Conserved protein"
/note="Rv2778c, (MTV002.43c), len: 156 aa. Conserved
protein, similar to Q9CBF7|ML2031 hypothetical protein
from Mycobacterium leprae (151 aa), FASTA scores: opt:
227, E(): 8.5e-09, (35.95% identity in 153 aa overlap).
Also similar to AAK46204|MT1931.1 hypothetical 17.8 KDA
protein from Mycobacterium tuberculosis strain CDC1551
(158 aa), FASTA scores: opt: 238, E(): 1.5e-09, (35.75%
identity in 151 aa overlap); or O07748|Rv1883c|MTCY180.35
hypothetical 17.3 KDA protein from Mycobacterium
tuberculosis strain H37Rv (158 aa), FASTA scores: opt:
212, E(): 9.7e-08, (34.45% identity in 151 aa overlap);
note that AAK46204|MT1931.1 and O07748|Rv1883c|MTCY180.35
are essentially the same protein except for a small (5 aa)
gap."
/db_xref="EnsemblGenomes-Gn:Rv2778c"
/db_xref="EnsemblGenomes-Tr:CCP45577"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:I6Y1P2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45577.1"
/translation="MPDPDGPSVTVTVEIDANPDLVYGLITDLPTLASLAEEVVAMQL
RKGDDVRKGAVFVGRNENGGRRWTTTCTVTDADPGRVFAFDVRSGIIPISRWQYGIVA
TEHGCRVTESTWDRRPSWFRAVARMATGVKDRASVNTEHIRRTLQRLKDRAEAG"
gene complement(3086215..3086754)
/locus_tag="Rv2779c"
CDS complement(3086215..3086754)
/codon_start=1
/transl_table=11
/locus_tag="Rv2779c"
/product="Possible transcriptional regulatory protein
(probably Lrp/AsnC-family)"
/note="Rv2779c, (MTV002.44c), len: 179 aa. Possible
transcriptional regulator, from the Lrp/AsnC
family,similar (but longer ~30 aa in N-terminus) to others
e.g. CAC42842|SCBAC36F5.06 putative AsnC-family
transcriptional regulatory protein from Streptomyces
coelicolor (163 aa),FASTA scores: opt: 333, E(): 4.4e-16,
(39.7% identity in 141 aa overlap); O07920|AZLB_BACSU
transcriptional regulator (AsnC family) from Bacillus
subtilis; Q9I233|PA2082 probable transcriptional regulator
(AsnC family) from Pseudomonas aeruginosa (158 aa), FASTA
scores: opt: 322, E(): 2.5e-15, (33.1% identity in 148 aa
overlap); etc. Also similar to P96896|Rv3291c|MTCY71.31c
from Mycobacterium tuberculosis (33.3% identity in 120 aa
overlap). Equivalent to AAK47168 from Mycobacterium
tuberculosis strain CDC1551 (181 aa). Seems to belong to
the AsnC family of transcriptional regulators. Start
changed since first submission (+8 aa)."
/db_xref="EnsemblGenomes-Gn:Rv2779c"
/db_xref="EnsemblGenomes-Tr:CCP45578"
/db_xref="GOA:O33321"
/db_xref="InterPro:IPR000485"
/db_xref="InterPro:IPR011008"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR019887"
/db_xref="InterPro:IPR019888"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:4PCQ"
/db_xref="UniProtKB/TrEMBL:O33321"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45578.1"
/translation="MIILFRGHMRDNSTEHKTRRAASSKDVRPAELDEVDRRILSLLH
GDARMPNNALADTVGIAPSTCHGRVRRLVDLGVIRGFYTDIDPVAVGLPLQAMISVNL
QSSARGKIRSFIQQIRRKRQVMDVYFLAGADDFILHVAARDTEDLRSFVVENLNADAD
VAGTQTSLIFEHLRGAAPI"
gene 3086820..3087935
/gene="ald"
/locus_tag="Rv2780"
CDS 3086820..3087935
/codon_start=1
/transl_table=11
/gene="ald"
/locus_tag="Rv2780"
/product="Secreted L-alanine dehydrogenase Ald (40 kDa
antigen) (TB43)"
/note="Rv2780, (MT2850, MTV002.45), len: 371 aa.
Ald,secreted L-alanine dehydrogenase (40 kd antigen);
equivalent to Q9CBV6|ALD|ML1532 L-alanine dehydrogenase
from Mycobacterium leprae (371 aa), FASTA scores: opt:
2081, E(): 4e-115, (85.45% identity in 371 aa overlap).
Also highly similar to others e.g. Q9S227|SCI51.13c from
Streptomyces coelicolor (371 aa), FASTA scores: opt:
1575,E(): 2.3e-85, (66.05% identity in 371 aa overlap);
Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA
scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372
aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans
(390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2%
identity in 371 aa overlap); etc. Contains PS00836 and
PS00837 Alanine dehydrogenase & pyridine nucleotide
transhydrogenase signature 1 and 2. Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2780"
/db_xref="EnsemblGenomes-Tr:CCP45579"
/db_xref="GOA:P9WQB1"
/db_xref="InterPro:IPR007698"
/db_xref="InterPro:IPR007886"
/db_xref="InterPro:IPR008141"
/db_xref="InterPro:IPR008142"
/db_xref="InterPro:IPR008143"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:2VHV"
/db_xref="PDB:2VHW"
/db_xref="PDB:2VHX"
/db_xref="PDB:2VHY"
/db_xref="PDB:2VHZ"
/db_xref="PDB:2VOE"
/db_xref="PDB:2VOJ"
/db_xref="UniProtKB/Swiss-Prot:P9WQB1"
/inference="protein motif:PROSITE:PS00836"
/inference="protein motif:PROSITE:PS00837"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45579.1"
/translation="MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSA
ITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAAEYGRLRHGQILFTFLHLAASRA
CTDALLDSGTTSIAYETVQTADGALPLLAPMSEVAGRLAAQVGAYHLMRTQGGRGVLM
GGVPGVEPADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTR
YSSAYELEGAVKRADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAIDQGGCFE
GSRPTTYDHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGWRAACR
SNPALAKGLSTHEGALLSERVATDLGVPFTEPASVLA"
gene complement(3087950..3088984)
/locus_tag="Rv2781c"
CDS complement(3087950..3088984)
/codon_start=1
/transl_table=11
/locus_tag="Rv2781c"
/product="Possible alanine rich oxidoreductase"
/note="Rv2781c, (MTV002.46c), len: 344 aa. Possible
ala-rich oxidoreductase, similar to various
oxidoreductases or hypothetical proteins e.g.
Q9RDD8|SCC77.20c putative oxidoreductase from Streptomyces
coelicolor (364 aa), FASTA scores: opt: 912, E(): 5.3e-47,
(45.55% identity in 336 aa overlap); Q9FDD4|2-NPDL
putative 2-nitropropane dioxygenase from Streptomyces
ansochromogenes (363 aa), FASTA scores: opt: 869, E():
1.9e-44, (44.2% identity in 337 aa overlap); O05413|YRPB
2-nitropropane dioxygenase from Bacillus subtilis (347
aa), FASTA scores: opt: 560, E(): 4.9e-26,(33.75% identity
in 317 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2781c"
/db_xref="EnsemblGenomes-Tr:CCP45580"
/db_xref="GOA:I6X5C5"
/db_xref="InterPro:IPR004136"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:I6X5C5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45580.1"
/translation="MVLGFWDIAVPIVGAPMAGGPSTPALAAAVSNAGGLGFVAGGYL
SADRLADDIAAARAATTGPIGANLFVPQPSVADWAQLEYYADELEEVAEYYHTEVGQP
VYGDDDDWVRKLEVVADVRPEVVSFTFGAPPPDVVQRLSALGLLVSITVTSVYEAGVA
IAAGADSLVVQGPAAGGHRGTFAPDMEPGTESLHQLLDRIGSAHDVPLVAAGGLGTAE
DVAAVLRRGAIAAQVGTALLLADEAGTNAAHRAALKNPEFDATLVTRAFSGRYARGLA
NNFTRLLDHVAPLGYPEVHQMTKPIRAAAVQADDPHGTNLWAGSAHRKTRPGPAADII
ASLTPDVCSA"
gene complement(3089045..3090361)
/gene="pepR"
/locus_tag="Rv2782c"
CDS complement(3089045..3090361)
/codon_start=1
/transl_table=11
/gene="pepR"
/locus_tag="Rv2782c"
/product="Probable zinc protease PepR"
/note="Rv2782c, (MTV002.47c), len: 438 aa. Probable
pepR,protease/peptidase, equivalent to
O32965|YR82_MYCLE|ML0855|MLCB22.26c hypothetical zinc
protease from Mycobacterium leprae (445 aa), FASTA scores:
opt: 2346, E(): 4.3e-146, (84.3% identity in 421 aa
overlap). Also highly similar to others e.g.
O86835|YA12_STRCO|SC9A10.02 from Streptomyces coelicolor
(459 aa), FASTA scores: opt: 1394, E(): 1.1e-83, (51.9%
identity in 416 aa overlap); Q04805|YMXG_BACSU|YMXG from
Bacillus subtilis (409 aa), FASTA scores: opt: 1014, E():
7.9e-59, (37.55% identity in 410 aa overlap);
Q9KA85|BH2405 from Bacillus halodurans (413 aa), FASTA
scores: opt: 967,E(): 9.6e-56, (38.6% identity in 417 aa
overlap); etc. Contains PS00143 Insulinase family,
zinc-binding region signature. Belongs to peptidase family
M16, also known as the insulinase family. Cofactor:
requires divalent cations for activity. Binds zinc.
Conserved in M. tuberculosis, M. leprae, M. bovis and M.
avium paratuberculosis; predicted to be essential for in
vivo survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2782c"
/db_xref="EnsemblGenomes-Tr:CCP45581"
/db_xref="GOA:P9WHT5"
/db_xref="InterPro:IPR001431"
/db_xref="InterPro:IPR007863"
/db_xref="InterPro:IPR011249"
/db_xref="InterPro:IPR011765"
/db_xref="UniProtKB/Swiss-Prot:P9WHT5"
/inference="protein motif:PROSITE:PS00143"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45581.1"
/translation="MPRRSPADPAAALAPRRTTLPGGLRVVTEFLPAVHSASVGVWVG
VGSRDEGATVAGAAHFLEHLLFKSTPTRSAVDIAQAMDAVGGELNAFTAKEHTCYYAH
VLGSDLPLAVDLVADVVLNGRCAADDVEVERDVVLEEIAMRDDDPEDALADMFLAALF
GDHPVGRPVIGSAQSVSVMTRAQLQSFHLRRYTPERMVVAAAGNVDHDGLVALVREHF
GSRLVRGRRPVAPRKGTGRVNGSPRLTLVSRDAEQTHVSLGIRTPGRGWEHRWALSVL
HTALGGGLSSRLFQEVRETRGLAYSVYSALDLFADSGALSVYAACLPERFADVMRVTA
DVLESVARDGITEAECGIAKGSLRGGLVLGLEDSSSRMSRLGRSELNYGKHRSIEHTL
RQIEQVTVEEVNAVARHLLSRRYGAAVLGPHGSKRSLPQQLRAMVG"
gene complement(3090339..3092597)
/gene="gpsI"
/locus_tag="Rv2783c"
CDS complement(3090339..3092597)
/codon_start=1
/transl_table=11
/gene="gpsI"
/locus_tag="Rv2783c"
/product="Bifunctional protein polyribonucleotide
nucleotidyltransferase GpsI: guanosine pentaphosphate
synthetase + polyribonucleotide nucleotidyltransferase
(polynucleotide phosphorylase) (pnpase)"
/note="Rv2783c, (MTV002.48c), len: 752 aa. Probable
gpsI,polyribonucleotide nucleotidyltransferase, equivalent
to Q9CCF8|GPSI|ML0854 (alias O32966) putative
polyribonucleotide phosphorylase / guanosine
pentaphosphate synthetase from Mycobacterium leprae (773
aa), FASTA scores: opt: 4304, E(): 0, (89.95% identity in
757 aa overlap). Also highly similar to others e.g.
O86656|GPSI guanosine pentaphosphate synthetase/
polyribonucleotide nucleotidyltransferase (fragment) from
Streptomyces coelicolor (716 aa), FASTA scores: opt: 3393,
E(): 5.8e-192, (72.77% identity in 718 aa overlap);
Q53597|GPSI guanosine pentaphosphate synthetase from
Streptomyces antibioticus (740 aa), FASTA scores: opt:
3314, E(): 2.6e-187, (70.55% identity in 733 aa overlap);
P72659|PNP|SLL1043 polyribonucleotide
nucleotidyltransferase from Synechocystis sp. strain PCC
6803 (718 aa), FASTA scores: opt: 1244, E():
1.7e-65,(45.05% identity in 750 aa overlap); etc. Note
that S. antibioticus guanosine pentaphosphate synthetase
is a multifunctional enzyme that also acts as a
polyribonucleotide nucleotidyltransferase. Start site
chosen by homology from several alternatives."
/db_xref="EnsemblGenomes-Gn:Rv2783c"
/db_xref="EnsemblGenomes-Tr:CCP45582"
/db_xref="GOA:P9WI57"
/db_xref="InterPro:IPR001247"
/db_xref="InterPro:IPR003029"
/db_xref="InterPro:IPR004087"
/db_xref="InterPro:IPR004088"
/db_xref="InterPro:IPR012162"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR014069"
/db_xref="InterPro:IPR015848"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR022967"
/db_xref="InterPro:IPR027408"
/db_xref="InterPro:IPR036345"
/db_xref="InterPro:IPR036456"
/db_xref="InterPro:IPR036612"
/db_xref="UniProtKB/Swiss-Prot:P9WI57"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45582.1"
/translation="MSAAEIDEGVFETTATIDNGSFGTRTIRFETGRLALQAAGAVVA
YLDDDNMLLSATTASKNPKEHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAIL
TCRLIDRPLRPSFVDGLRNEIQIVVTILSLDPGDLYDVLAINAASASTQLGGLPFSGP
IGGVRVALIDGTWVGFPTVDQIERAVFDMVVAGRIVEGDVAIMMVEAEATENVVELVE
GGAQAPTESVVAAGLEAAKPFIAALCTAQQELADAAGKSGKPTVDFPVFPDYGEDVYY
SVSSVATDELAAALTIGGKAERDQRIDEIKTQVVQRLADTYEGREKEVGAALRALTKK
LVRQRILTDHFRIDGRGITDIRALSAEVAVVPRAHGSALFERGETQILGVTTLDMIKM
AQQIDSLGPETSKRYMHHYNFPPFSTGETGRVGSPKRREIGHGALAERALVPVLPSVE
EFPYAIRQVSEALGSNGSTSMGSVCASTLALLNAGVPLKAPVAGIAMGLVSDDIQVEG
AVDGVVERRFVTLTDILGAEDAFGDMDFKVAGTKDFVTALQLDTKLDGIPSQVLAGAL
EQAKDARLTILEVMAEAIDRPDEMSPYAPRVTTIKVPVDKIGEVIGPKGKVINAITEE
TGAQISIEDDGTVFVGATDGPSAQAAIDKINAIANPQLPTVGERFLGTVVKTTDFGAF
VSLLPGRDGLVHISKLGKGKRIAKVEDVVNVGDKLRVEIADIDKRGKISLILVADEDS
TAAATDAATVTS"
gene complement(3092951..3093466)
/gene="lppU"
/locus_tag="Rv2784c"
CDS complement(3092951..3093466)
/codon_start=1
/transl_table=11
/gene="lppU"
/locus_tag="Rv2784c"
/product="Probable lipoprotein LppU"
/note="Rv2784c, (MTV002.49c), len: 171 aa. Probable
lppU,lipoprotein, sharing no homology with other proteins.
Contains signal sequence and appropriately positioned
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site."
/db_xref="EnsemblGenomes-Gn:Rv2784c"
/db_xref="EnsemblGenomes-Tr:CCP45583"
/db_xref="UniProtKB/TrEMBL:I6XFA6"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45583.1"
/translation="MRAWLAAATTALFVVATGCSSATNVAELKVGDCVKLAGTPDRPQ
ATKAECGSPASNFKVVAVVQEDHAECPADVDSTYSMRNAFNGSTNTICLDIDWVIGGC
MSVDPTHNTDPFRVDCDDASVPHRQRATQILKDLDSPVSVDQCASGVGYVYTQRRFAV
CVEDVTGGPRS"
gene complement(3093479..3093748)
/gene="rpsO"
/locus_tag="Rv2785c"
CDS complement(3093479..3093748)
/codon_start=1
/transl_table=11
/gene="rpsO"
/locus_tag="Rv2785c"
/product="30S ribosomal protein S15 RpsO"
/note="Rv2785c, (MTV002.50c), len: 89 aa. rpsO, 30s
ribosomal protein S15, equivalent to
O32967|RS15_MYCLE|RPSO|ML0853|MLCB22.28c 30S ribosomal
protein S15 from Mycobacterium leprae (89 aa), FASTA
scores: opt: 522, E(): 7.4e-34, (92.15% identity in 89 aa
overlap). Also highly similar to many e.g.
O86655|RS15_STRCO|RPSO|SC3C3.22 from Streptomyces
coelicolor (95 aa), FASTA scores: opt: 408, E():
6.7e-25,(62.9% identity in 89 aa overlap);
P05766|RS15_BACST|RPSO from Bacillus stearothermophilus
(88 aa), FASTA scores: opt: 385, E(): 4e-23, (62.5%
identity in 88 aa overlap); P21473|RS15_BACSU|RPSO from
Bacillus subtilis (88 aa),FASTA scores: opt: 351, E():
1.9e-20, (57.95% identity in 88 aa overlap);
P02371|RS15_ECOLI|RPSO|sec|B3165 from Escherichia coli
strain K12 (88 aa), FASTA scores: opt: 295, E(): 4.5e-22,
(52.3% identity in 88 aa overlap); etc. Contains PS00362
Ribosomal protein S15 signature. Belongs to the S15P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv2785c"
/db_xref="EnsemblGenomes-Tr:CCP45584"
/db_xref="GOA:P9WH55"
/db_xref="InterPro:IPR000589"
/db_xref="InterPro:IPR005290"
/db_xref="InterPro:IPR009068"
/db_xref="UniProtKB/Swiss-Prot:P9WH55"
/inference="protein motif:PROSITE:PS00362"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45584.1"
/translation="MALTAEQKKEILRSYGLHETDTGSPEAQIALLTKRIADLTEHLK
VHKHDHHSRRGLLLLVGRRRRLIKYISQIDVERYRSLIERLGLRR"
gene complement(3093905..3094900)
/gene="ribF"
/locus_tag="Rv2786c"
CDS complement(3093905..3094900)
/codon_start=1
/transl_table=11
/gene="ribF"
/locus_tag="Rv2786c"
/product="Probable bifunctional FAD synthetase/riboflavin
biosynthesis protein RibF: riboflavin kinase (flavokinase)
+ FMN adenylyltransferase (FAD pyrophosphorylase) (FAD
synthetase)(FAD diphosphorylase) (flavin adenine
dinucleotide synthetase)"
/note="Rv2786c, (MTV002.51c), len: 331 aa. Probable
ribF,FAD synthetase/riboflavin biosynthesis
protein,bifunctional enzyme, equivalent to
O32968|RIBF|ML0852 riboflavin kinase from Mycobacterium
leprae (331 aa), FASTA scores: opt: 1923, E(): 2.3e-115,
(87.45% identity in 327 aa overlap). Also highly similar
to many e.g. Q59263|RIBF_CORAM from Corynebacterium
ammoniagenes (Brevibacterium ammoniagenes) (338 aa), FASTA
scores: opt: 899, E(): 5.7e-50, (45.8% identity in 321 aa
overlap); Q9Z530|SC9F2.05c from Streptomyces coelicolor
(318 aa),FASTA scores: opt: 862, E(): 1.3e-47, (52.45%
identity in 324 aa overlap);
P08391|RIBF_ECOLI|B0025|Z0029\ECS0028 from Escherichia
coli strains K12 and O157:H7 (313 aa), FASTA scores: opt:
517, E(): 1.3e-25, (36.05% identity in 305 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2786c"
/db_xref="EnsemblGenomes-Tr:CCP45585"
/db_xref="GOA:I6X5C9"
/db_xref="InterPro:IPR002606"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR015864"
/db_xref="InterPro:IPR015865"
/db_xref="InterPro:IPR023465"
/db_xref="InterPro:IPR023468"
/db_xref="UniProtKB/TrEMBL:I6X5C9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45585.1"
/translation="MRRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHAELIAH
AVKAGRARGVPAVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELVQDLGIEVFLVMPFT
TDFMKLTPDRFIHELLVEHLHVVEVVVGENFTFGKKAAGNVDTLRRAGERFGFAVESM
SLVSEHHSNETVTFSSTYIRSCVDAGDMVAAMEALGRPHRVEGVVVRGEGRGAELGFP
TANVAPPMYSAIPADGVYAAWFTVLGHGPVTGTVVPGERYQAAVSVGTNPTFSGRTRT
VEAFVLDTTADLYGQHVALDFVGRIRGQKKFESVRQLVAAMGADTERARDLLSTG"
gene 3095111..3096874
/locus_tag="Rv2787"
CDS 3095111..3096874
/codon_start=1
/transl_table=11
/locus_tag="Rv2787"
/product="Conserved hypothetical alanine rich protein"
/note="Rv2787, (MTV002.52), len: 587 aa. Conserved
hypothetical ala-rich protein, equivalent to Q9CCI1|ML0798
hypothetical protein from Mycobacterium leprae (592
aa),FASTA scores: opt: 2994, E(): 6.9e-179, (76.5%
identity in 587 aa overlap); and similar in part to other
proteins from Mycobacterium leprae e.g. O33082|MLCB628.11
hypothetical 52.0 KDA protein (478 aa), FASTA scores: opt:
481, E(): 2.3e-22, (30.95% identity in 294 aa overlap).
Also similar in part to O86637|SC3C3.03c hypothetical
112.1 KDA protein from Streptomyces coelicolor (1083 aa),
FASTA scores: opt: 488, E(): 1.5e-22, (28.95% identity in
297 aa overlap). And similar to other hypothetical
proteins from Mycobacterium tuberculosis e.g.
O06396|Rv0530|MTCY25D10.09 (405 aa),FASTA scores: opt:
625, E(): 2.2e-31, (34.05% identity in 320 aa overlap);
O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt: 453,
E(): 1.6e-20, (29.2% identity in 370 aa overlap);
P96217|Rv3860|MTCY01A6.08c (390 aa), FASTA scores: opt:
443, E(): 4.7e-20, (29.95% identity in 354 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2787"
/db_xref="EnsemblGenomes-Tr:CCP45586"
/db_xref="GOA:O33329"
/db_xref="InterPro:IPR002586"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O33329"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45586.1"
/translation="MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGW
LGLLACGDHHLDTLAGAHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATI
GLAYASALIIADRHDEAAATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTE
ISPPSGATDVRDEVADAVAALASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRA
WCLRELGDDDAARVALSATTTGDAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRP
PAGDGWRKAVTKMTFGRVNPEPSAKREQTDELIQRICAPLADVHKLAFVSAKGGVGKT
TMTVLVGNAVARLRGDRVMAVDVDADLGDLSARFSERGGPQTNIEHFVSSQHTKRYAD
VRVHTVMNKDRLEMLGAQNDPRSTYKFGPEDYGAAMQILETHCNVILLDCGTPVNGPL
FSNILNDVTGLVVVASEDVRGVEGALVTLDWLGAHGFGRLLQHTVVVLNAIQKTRSLV
DCGAAENQFRKRVPDFFRIPYDPHLATGLAVDFSSLKRRTRNAVLDLAGGLAQHYPAS
RVRPRGEDSWKTWIETMRQVG"
gene 3096959..3097645
/gene="sirR"
/locus_tag="Rv2788"
CDS 3096959..3097645
/codon_start=1
/transl_table=11
/gene="sirR"
/locus_tag="Rv2788"
/product="Probable transcriptional repressor SirR"
/note="Rv2788, (MTV002.53), len: 228 aa. Probable
sirR,transcriptional repressor, highly similar to others
e.g. Q9RRF3|DR2539 putative iron dependent repressor from
Deinococcus radiodurans (232 aa), FASTA scores: opt:
518,E(): 4.5e-26, (41.2% identity in 221 aa overlap);
Q9HRU8|SIRR|VNG0536G from Halobacterium sp. strain NRC-1
(233 aa), FASTA scores: opt: 516, E(): 6.1e-26, (40.45%
identity in 220 aa overlap); Q9KIJ2|SLOR regulator SLOR
from Streptococcus mutans (217 aa), FASTA scores: opt:
418,E(): 1.2e-19, (36.15% identity in 213 aa overlap);
etc. Also some similarity to
Q50495|IDER_MYCTU|MTCY05A6.32|IDER|DTXR|Rv2711|MT2784|MTCY
05A6.32 iron-dependent repressor from Mycobacterium
tuberculosis (230 aa), FASTA scores: opt: 266, E():
7.1e-10, (27.6% identity in 221 aa overlap). Contains
helix-turn-helix motif at aa 32-53 (Score 1327, +3.71 SD).
Could belong to the Crp/Fnr family of transcriptional
regulators."
/db_xref="EnsemblGenomes-Gn:Rv2788"
/db_xref="EnsemblGenomes-Tr:CCP45587"
/db_xref="GOA:I6Y1Q2"
/db_xref="InterPro:IPR000485"
/db_xref="InterPro:IPR001367"
/db_xref="InterPro:IPR007167"
/db_xref="InterPro:IPR008988"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR022687"
/db_xref="InterPro:IPR022689"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="InterPro:IPR036421"
/db_xref="PDB:5ZR6"
/db_xref="UniProtKB/TrEMBL:I6Y1Q2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45587.1"
/translation="MRADEEPGDLSAVAQDYLKVIWTAQEWSQDKVSTKMLAERIGVS
ASTASESIRKLAEQGLVDHEKYGAVTLTDSGRRAALAMVRRHRLLETFLVNELGYRWD
EVHDEAEVLEHAVSDRLMARIDAKLGFPQRDPHGDPIPGADGQVPTPPARQLWACRDG
DTGTVARISDADPQMLRYFASIGISLDSRLRVLARREFAGMISVAIDSADGATVDLGS
PAAQAIWVVS"
gene complement(3097706..3098938)
/gene="fadE21"
/locus_tag="Rv2789c"
CDS complement(3097706..3098938)
/codon_start=1
/transl_table=11
/gene="fadE21"
/locus_tag="Rv2789c"
/product="Probable acyl-CoA dehydrogenase FadE21"
/note="Rv2789c, (MTV002.54c), len: 410 aa. Probable
fadE21,acyl-CoA dehydrogenase, similar to many e.g.
P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379
aa),FASTA scores: opt: 689, E(): 9.3e-37, (35.75% identity
in 400 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus
halodurans (380 aa), FASTA scores: opt: 679, E():
4.1e-36,(37.3% identity in 405 aa overlap);
Q06319|ACDS_MEGEL from Megasphaera elsdenii (383 aa),
FASTA scores: opt: 650, E(): 3e-34, (37.7% identity in 334
aa overlap); etc. Contains acyl-CoA dehydrogenases
signature 1 (PS00072). Belongs to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv2789c"
/db_xref="EnsemblGenomes-Tr:CCP45588"
/db_xref="GOA:I6XFA9"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:I6XFA9"
/inference="protein motif:PROSITE:PS00072"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45588.1"
/translation="MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKL
FSQFGLDVLLAESVNQMLDGERAKREKRDSSGSFGLADQASMVAVLVSELAGVSIGLL
STVAVSLGLGAATIMSRGTLAQQERWVPTLVTLEKIAAWAITEPDSGSDAFGGMKTHV
TRDGEDYILNGHKTFITNGPYADVLVVYAKLADGEPASDWRNRPVLVFVLDAGMPGLT
QGKPFKKMGMMSSPTGELFFDNVRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLG
IINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQNMVFQAIERLKAGK
QLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNE
VQVTHIAKGLLGEPASRA"
gene complement(3098964..3100169)
/gene="ltp1"
/locus_tag="Rv2790c"
CDS complement(3098964..3100169)
/codon_start=1
/transl_table=11
/gene="ltp1"
/locus_tag="Rv2790c"
/product="Probable lipid-transfer protein Ltp1"
/note="Rv2790c, (MTV002.55c), len: 401 aa. Probable
ltp1,lipid-transfer protein, highly similar to many
eukaryotic sterol-carrier proteins/lipid-transfer protein
precursors (see Ossendorp & Wirtz 1993) e.g. O62742|SCP2
sterol carrier protein X from Oryctolagus cuniculus
(Rabbit) (547 aa), FASTA scores: opt: 1710, E(): 6e-102,
(63.7% identity in 394 aa overlap); Q9QW19 3-oxoacyl-CoA
thiolase homolog (fragment) from Rattus sp. (405 aa),
FASTA scores: opt: 1696, E(): 3.8e-101, (63.2% identity in
394 aa overlap); P11915|NLTP_RAT|SCP2|SCP-2 nonspecific
lipid-transfer protein precursor from Rattus norvegicus
(Rat) (547 aa),FASTA scores: opt: 1696, E(): 4.8e-101,
(63.2% identity in 394 aa overlap);
P32020|NLTP_MOUSE|SCP2|SCP-2 nonspecific lipid-transfer
protein precursor from Mus musculus (Mouse) (547 aa),
FASTA scores: opt: 1681, E(): 4.3e-100, (62.7% identity in
394 aa overlap); etc. Contains PS00098 Thiolases
acyl-enzyme intermediate signature and PS00737 Thiolases
signature 2. Also similar to other M. tuberculosis
proteins e.g. O06144|Rv1627c|MTCY01B2.19c (402 aa) (35.8%
identity in 413 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2790c"
/db_xref="EnsemblGenomes-Tr:CCP45589"
/db_xref="GOA:O33332"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020613"
/db_xref="InterPro:IPR020615"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/TrEMBL:O33332"
/inference="protein motif:PROSITE:PS00737"
/inference="protein motif:PROSITE:PS00098"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45589.1"
/translation="MPNQGSSNKVYVIGVGMTKFEKPGRREGWDYPDMARESGTKALR
DAGIDYREVEQGYVGYVYGESTSGQRALYELGMTGIPIVNVNNNCSTGSTALYLGAQA
IRGGLADCVLALGFEKMQPGALGGGADDRESPLGRHVKALAEIDEFGFPVAPWMFGAA
GREHMKKYGTTAEHFAKIGYKNHKHSVNNPYAQFQDEYTLDDILASKMISDPLTKLQC
SPTSDGSAAVVLASEDYLANHNLAGRAVEIVGQAMTTDFASTFDGSARNIIGYDMTVQ
AAQRVYQQSGLGPKDFGVIELHDCFSANELLLYEALGLCGPGEAPELIDDNQTTYGGR
WVVNPSGGLISKGHPLGATGLAQCAELTWQLRGTAEARQVDNVTAALQHNIGLGGAAV
VTAYQRAER"
mobile_element 3100175..3102206
/mobile_element_type="insertion sequence:IS1602"
/note="IS1602, len: 2032 nt. Insertion sequence IS1602."
gene complement(3100202..3101581)
/locus_tag="Rv2791c"
CDS complement(3100202..3101581)
/codon_start=1
/transl_table=11
/locus_tag="Rv2791c"
/product="Probable transposase"
/note="Rv2791c, (MTV002.56c), len: 459 aa. Probable IS1602
transposase for IS1602 element, similar to many e.g.
P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis
(459 aa), FASTA scores: opt: 2718, E(): 6.3e-165, (86.05%
identity in 459 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2791c"
/db_xref="EnsemblGenomes-Tr:CCP45590"
/db_xref="GOA:O33333"
/db_xref="InterPro:IPR001959"
/db_xref="InterPro:IPR010095"
/db_xref="InterPro:IPR021027"
/db_xref="UniProtKB/TrEMBL:O33333"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45590.1"
/translation="MAKFEIPEGWMVQAFRFTLDPTAEQARALARHFGARRKAYNWTV
ATLKADIDAWQATGIQTAKPSLRVLRKRWNTVKNDVCVNIETGVVWWPECSKEAYADG
IDGAVDAYWNWQNSRSGKRDGKRMGFPRFKKKGRDPDRVTFTTGAMRVEPDRRHLTLP
VIGTVRTHENTRRVERLIAKGRSRVLAITVRRNGTRIDASVRVLVQRPQQPKVTDPGS
RVGVDVGVRRLATVATADGAVLERVPNPRPLDAALNELRHVCRARSRCTKGSRRYRER
TTEISRLHRRVNDVRTHHLHCLTTHLAKTHGRIVVEGLDAAGMLRQQGLSGARARRRG
LSDAALGTPRRHLSYKTGWYGSQLVVADRWFPSSKTCHVCGHVQEIGWAEHWQCDSCS
ASHQRDDCAAINLARYEDTSSVVGPVGAAVKRGADRKTRPGRAGGREARKGSSRKAAE
QPRDGVQVA"
gene complement(3101581..3102162)
/locus_tag="Rv2792c"
CDS complement(3101581..3102162)
/codon_start=1
/transl_table=11
/locus_tag="Rv2792c"
/product="Possible resolvase"
/note="Rv2792c, (MTV002.57c), len: 193 aa. Possible IS1602
resolvase, highly similar to many from Mycobacterium
tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c possible
resolvase (202 aa), FASTA scores: opt: 1040, E():
1.9e-62,(85.05% identity in 194 aa overlap). Contains
PS00397 Site-specific recombinases active site and
possible helix-turn-helix motif at aa 1-2 (Score 1687,
+4.93 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2792c"
/db_xref="EnsemblGenomes-Tr:CCP45591"
/db_xref="GOA:I6YA93"
/db_xref="InterPro:IPR006118"
/db_xref="InterPro:IPR006119"
/db_xref="InterPro:IPR036162"
/db_xref="InterPro:IPR041718"
/db_xref="UniProtKB/TrEMBL:I6YA93"
/inference="protein motif:PROSITE:PS00397"
/protein_id="CCP45591.1"
/translation="MNLAVWAERNGVARVTAYRWFHAGLLPVPARKAGRLILVDDQPA
DRSRRARTAVYARVSSADQKPDLDRQVARVTAWATTEQIAVDKVVTEVGSALNGHRRK
FLALLRDPSVKRIVVEHRDRFCRFGSEYVEAALAAQGRELVVVDSAEVDDDLVRDMTE
ILTSMCARLYGKRAAQNRAKRALAAAAEESEAA"
gene complement(3102364..3103260)
/gene="truB"
/locus_tag="Rv2793c"
CDS complement(3102364..3103260)
/codon_start=1
/transl_table=11
/gene="truB"
/locus_tag="Rv2793c"
/product="Probable tRNA pseudouridine synthase B TruB
(tRNA pseudouridine 55 synthase) (PSI55 synthase)
(pseudouridylate synthase) (uracil hydrolyase)"
/note="Rv2793c, (MTV002.58c), len: 298 aa. Probable
truB,tRNA pseudouridine synthase, equivalent to
Q9Z5I4|TRUB_MYCLE|ML1546 or MLCB596.24 tRNA pseudouridine
synthase B from Mycobacterium leprae (320 aa), FASTA
scores: opt: 1403, E(): 2.9e-83, (74.05% identity in 293
aa overlap). Also highly similar to many e.g.
Q9Z528|TRUB_STRCO|SC9F2.07c from Streptomyces coelicolor
(301 aa), FASTA scores: opt: 870, E(): 7.6e-49, (50.7%
identity in 296 aa overlap);
P09171|TRUB_ECOLI|P35|B3166|Z4527|ECS4047 from Escherichia
coli strains K12 and O157:H7 (314 aa), FASTA scores: opt:
574, E(): 1e-29, (42.5% identity in 214 aa overlap);
Q9PGR1|TRUB_XYLFA|XF0237 from Xylella fastidiosa (302
aa),FASTA scores: opt: 569, E(): 2.1e-29, (41.05% identity
in 285 aa overlap); etc. Belongs to the TruB family of
pseudouridine synthases."
/db_xref="EnsemblGenomes-Gn:Rv2793c"
/db_xref="EnsemblGenomes-Tr:CCP45592"
/db_xref="GOA:P9WHP7"
/db_xref="InterPro:IPR002501"
/db_xref="InterPro:IPR014780"
/db_xref="InterPro:IPR015225"
/db_xref="InterPro:IPR015947"
/db_xref="InterPro:IPR020103"
/db_xref="InterPro:IPR032819"
/db_xref="InterPro:IPR036974"
/db_xref="PDB:1SGV"
/db_xref="UniProtKB/Swiss-Prot:P9WHP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45592.1"
/translation="MSATGPGIVVIDKPAGMTSHDVVGRCRRIFATRRVGHAGTLDPM
ATGVLVIGIERATKILGLLTAAPKSYAATIRLGQTTSTEDAEGQVLQSVPAKHLTIEA
IDAAMERLRGEIRQVPSSVSAIKVGGRRAYRLARQGRSVQLEARPIRIDRFELLAARR
RDQLIDIDVEIDCSSGTYIRALARDLGDALGVGGHVTALRRTRVGRFELDQARSLDDL
AERPALSLSLDEACLLMFARRDLTAAEASAAANGRSLPAVGIDGVYAACDADGRVIAL
LRDEGSRTRSVAVLRPATMHPG"
gene complement(3103257..3103940)
/gene="pptT"
/locus_tag="Rv2794c"
CDS complement(3103257..3103940)
/codon_start=1
/transl_table=11
/gene="pptT"
/locus_tag="Rv2794c"
/product="Phosphopantetheinyl transferase PptT
(CoA:APO-[ACP]pantetheinephosphotransferase)
(CoA:APO-[acyl-carrier
protein]pantetheinephosphotransferase)"
/note="Rv2794c, (MTV002.59c), len: 227 aa.
PptT,phosphopantetheinyl transferase, equivalent to
Q9Z5I5|ML1547|MLCB596.23 putative iron-chelating complex
subunit from Mycobacterium leprae (227 aa), FASTA scores:
opt: 1248, E(): 9.1e-77, (79.75% identity in 227 aa
overlap). Also highly similar to various proteins e.g.
Q9F0Q6|PPTA phosphopantetheinyl transferase from
Streptomyces verticillus (246 aa), FASTA scores: opt:
692,E(): 2.8e-39, (46.65% identity in 225 aa overlap);
O88029|SC5A7.23 hypothetical 24.5 KDA protein from
Streptomyces coelicolor (226 aa), FASTA scores: opt:
679,E(): 2e-38, (46.9% identity in 226 aa overlap); O24813
DNA for L-proline 3-hydroxylase from Streptomyces sp. (208
aa),FASTA scores: opt: 631, E(): 3.2e-35, (48.1% identity
in 208 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2794c"
/db_xref="EnsemblGenomes-Tr:CCP45593"
/db_xref="GOA:O33336"
/db_xref="InterPro:IPR003542"
/db_xref="InterPro:IPR008278"
/db_xref="InterPro:IPR037143"
/db_xref="InterPro:IPR041354"
/db_xref="PDB:4QJK"
/db_xref="PDB:4QVH"
/db_xref="PDB:4U89"
/db_xref="UniProtKB/TrEMBL:O33336"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45593.1"
/translation="MTVGTLVASVLPATVFEDLAYAELYSDPPGLTPLPEEAPLIARS
VAKRRNEFITVRHCARIALDQLGVPPAPILKGDKGEPCWPDGMVGSLTHCAGYRGAVV
GRRDAVRSVGIDAEPHDVLPNGVLDAISLPAERADMPRTMPAALHWDRILFCAKEATY
KAWFPLTKRWLGFEDAHITFETDSTGWTGRFVSRILIDGSTLSGPPLTTLRGRWSVER
GLVLTAIVL"
gene complement(3103937..3104911)
/locus_tag="Rv2795c"
CDS complement(3103937..3104911)
/codon_start=1
/transl_table=11
/locus_tag="Rv2795c"
/product="Conserved hypothetical protein"
/note="Rv2795c, (MTV002.60c), len: 324 aa. Conserved
hypothetical protein, equivalent to
Q9Z5I6|ML1548|MLCB596.22 hypothetical 37.5 KDA protein
from Mycobacterium leprae (321 aa), FASTA scores: opt:
2018,E(): 6.3e-128, (87.4% identity in 318 aa overlap).
Also highly similar to O88028|SC5A7.22 hypothetical 33.5
KDA protein from Streptomyces coelicolor (295 aa), FASTA
scores: opt: 1202, E(): 3.4e-73, (57.2% identity in 285 aa
overlap); and Q9AMH7|SIMX4 SIMX4 protein from Streptomyces
antibioticus (293 aa), FASTA scores: opt: 1045, E():
1.2e-62, (51.4% identity in 286 aa overlap). C-terminus
highly similar to Q9F0Q7 hypothetical 9.6 KDA protein
(fragment) from Streptomyces verticillus (81 aa), FASTA
scores: opt: 395, E(): 1.8e-19, (68.35% identity in 79 aa
overlap). Also similar to other proteins e.g. Q9FWV7
hypothetical 45.3 KDA protein from Oryza sativa (Rice)
(402 aa), FASTA scores: opt: 294, E(): 3.6e-12, (26.45%
identity in 340 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2795c"
/db_xref="EnsemblGenomes-Tr:CCP45594"
/db_xref="GOA:I6YEE1"
/db_xref="InterPro:IPR004843"
/db_xref="UniProtKB/TrEMBL:I6YEE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45594.1"
/translation="MTWKGSGQETVGAEPTLWAISDLHTGHLGNKPVAESLYPSSPDD
WLIVAGDVAERTDEIRWSLDLLRRRFAKVIWVPGNHELWTTNRDPMQIFGRARYDYLV
NMCDEMGVVTPEHPFPVWTERGGPATIVPMFLLYDYSFLPEGANSKAEGVAIAKERNV
VATDEFLLSPEPYPTRDAWCHERVAATRARLEQLDWMQPTVLVNHFPLLRQPCDALFY
PEFSLWCGTTKTADWHTRYNAVCSVYGHLHIPRTTWYDGVRFEEVSVGYPREWRRRKP
YSWLRQVLPDPQYAPGYLNDFGGHFVITPEMRTQAAQFRERLRQRQSR"
gene complement(3105056..3105619)
/gene="lppV"
/locus_tag="Rv2796c"
CDS complement(3105056..3105619)
/codon_start=1
/transl_table=11
/gene="lppV"
/locus_tag="Rv2796c"
/product="Probable conserved lipoprotein LppV"
/note="Rv2796c, (MTV002.61c, MTCY16B7.47), len: 187 aa.
Probable lppV, conserved lipoprotein, similar to others
from Mycobacterium tuberculosis e.g.
P95009|LPPB|Rv2544|MTCY159.12c probable conserved
lipoprotein (220 aa), FASTA scores: opt: 168, E():
0.00066,(22.45% identity in 196 aa overlap); and
P95010|LPPA|RV2543|MTCY159.13c probable conserved
lipoprotein (219 aa), FASTA scores: opt: 165, E():
0.001,(23.1% identity in 199 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2796c"
/db_xref="EnsemblGenomes-Tr:CCP45595"
/db_xref="InterPro:IPR032018"
/db_xref="UniProtKB/TrEMBL:P71655"
/protein_id="CCP45595.1"
/translation="MRWPTAWLLALVCVMATGCGPSGHGTRAGEEGPLSPEKVAELEN
PLRAKPPLEDAKDQYRAAVTQLANAITALVPGLTWRTDMDTWTGCGGEYEWTRAKAAY
FMIVFSGPIPDDKWLQAVQIVKDGVEQFGATGFGVMKNKPADHDVYFAGHGGVEFKCS
TQKAAVLTAQSDCRISRTDTPKPSPTP"
gene complement(3105619..3107307)
/locus_tag="Rv2797c"
CDS complement(3105619..3107307)
/codon_start=1
/transl_table=11
/locus_tag="Rv2797c"
/product="Conserved hypothetical protein"
/note="Rv2797c, (MTCY16B7.46), len: 562 aa. Conserved
hypothetical ala-rich protein. C-terminus highly similar
to several mycobacterial proteins e.g. AAK46927|MT2616
hypothetical 28.0 KDA protein from Mycobacterium
tuberculosis strain CDC1551 (265 aa), FASTA scores: opt:
535, E(): 4.6e-22, (42.95% identity in 263 aa overlap);
P95011|Rv2542|MTCY159.14c hypothetical 42.4 KDA protein
from Mycobacterium tuberculosis (403 aa), FASTA scores:
opt: 537, E(): 5e-22, (40.75% identity in 292 aa overlap)
(similarity in the second half of protein);
P71547|Y963_MYCTU|Rv0963c|MT0992|MTCY10D7.11 hypothetical
28.1 KDA protein (266 aa), FASTA scores: opt: 314, E():
5.7e-10, (39.0% identity in 254 aa overlap); etc. Contains
PS00120 Lipases, serine active site."
/db_xref="EnsemblGenomes-Gn:Rv2797c"
/db_xref="EnsemblGenomes-Tr:CCP45596"
/db_xref="InterPro:IPR010427"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P71654"
/inference="protein motif:PROSITE:PS00120"
/protein_id="CCP45596.1"
/translation="MPLTVADIDRWNAQAVREVFHAASARAEVTFEASRQLAALSIFA
NSGGKTAEAAAHHNAGIRRDLDAHGNEALAVARAADRAADGIVKVQSELAALRHAAAA
AELTIDALINRVVPIPGLRSTEAQWARTLAKQTELQAELDAIMAEANAVDEELASAVN
MADGDAPIPADSGPPVGPEGLTPTQLASDANEERLREERARLQAHLERLQAEYDQLSV
RAARDYHNGILDGDAVGRLAALTDELSAARGRLGELDAVDEALSRAPETYLTQLQIPE
DPNQQVLAAVAVGNPDTAANVSVTVPGVGSTTRGALPGMVTEARDLRSEVIRQLNAAG
KPASVATIAWMGYHPPPNPLDTGSAGDLWQTMTDGQAHAGAADLSRYLQQVRANNPSG
HLTVLGHSYGSLTASLALQDLDAQSAHPVNDVVFYGSPGLELYSPAQLGLDHGHAYVM
QAPHDLITNLVAPLAPLHGWGLDPYLTPGFTELSSQAGFDPGGIWRDGVYAHGDYPRS
FLDAAGQPQLRMSGYNLAAIAAGLPDNTVGPPLLPPILGGGMPAAPGPALRGGR"
gene complement(3107311..3107637)
/locus_tag="Rv2798c"
CDS complement(3107311..3107637)
/codon_start=1
/transl_table=11
/locus_tag="Rv2798c"
/product="Conserved hypothetical protein"
/note="Rv2798c, (MTCY16B7.45), len: 108 aa. Conserved
hypothetical ala-rich protein, similar to
P71545|Y965_MYCTU|Rv0965c|MT0993|MTCY10D7.09 hypothetical
14.5 KDA protein from Mycobacterium tuberculosis (139
aa),FASTA scores: opt: 198, E(): 8e-07, (38.9% identity in
90 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2798c"
/db_xref="EnsemblGenomes-Tr:CCP45597"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/TrEMBL:P71653"
/protein_id="CCP45597.1"
/translation="MFQISPEQWMHSAAQVTTQGEGLAVGHLSSDYRMQAAQFGWQGA
SAMALNAKMDDWLDASRALLTRIGDHAFGLQEAAIQHAAAEAERAQALAQVGVSADVV
AGPRGV"
gene 3107768..3108397
/locus_tag="Rv2799"
CDS 3107768..3108397
/codon_start=1
/transl_table=11
/locus_tag="Rv2799"
/product="Probable membrane protein"
/note="Rv2799, (MTCY16B7.44c), len: 209 aa. Probable
membrane protein. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2799"
/db_xref="EnsemblGenomes-Tr:CCP45598"
/db_xref="GOA:I6XFB7"
/db_xref="InterPro:IPR024520"
/db_xref="UniProtKB/TrEMBL:I6XFB7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45598.1"
/translation="MYTPGKGPPRAGGVVFTRVRLIGGLGALTAAVVVVGTVGWQGIP
PAPTGGDAVQLRSTAAPMSTTMKSPIVATTDPSPFDPCRDIPFDVIQRLGLAYTPPEA
EEGLRCHFDAGNYQMAVEPIIWRTYAQTLPPDAIETTIAGHRAAQYWVRKPTYHNSFW
YSSCMVTFKTSYGVIQQSLFYSTVYSEPDVDCPSTNLQRANDLVPYYRF"
gene 3108416..3110065
/locus_tag="Rv2800"
CDS 3108416..3110065
/codon_start=1
/transl_table=11
/locus_tag="Rv2800"
/product="Possible hydrolase"
/note="Rv2800, (MTCY16B7.43c), len: 549 aa. Possible
hydrolase, an esterase or an acylase. Similar, but longer
in N-terminus, to esterases or acylases e.g. Q9L9D7|COCE
cocaine esterase from Rhodococcus sp. MB1 'Bresler 1999'
(574 aa), FASTA scores: opt: 510, E(): 3.1e-23, (33.6%
identity in 571 aa overlap); Q9L3U2|STTE putative acylase
from Streptomyces rochei (Streptomyces parvullus) (554
aa),FASTA scores: opt: 492, E(): 3.7e-22, (34.45% identity
in 569 aa overlap); CAC49652|SMB21424 putative esterase or
acylase protein from Rhizobium meliloti (Sinorhizobium
meliloti) plasmid pSymB (578 aa), FASTA scores: opt:
405,E(): 7.1e-17, (34.45% identity in 569 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2800"
/db_xref="EnsemblGenomes-Tr:CCP45599"
/db_xref="GOA:I6YEE6"
/db_xref="InterPro:IPR000383"
/db_xref="InterPro:IPR005674"
/db_xref="InterPro:IPR008979"
/db_xref="InterPro:IPR013736"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6YEE6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45599.1"
/translation="MSTTSARPERPKLRALTGRVGGQALGGLLGLPRATTRYTVGHVR
VPMRDGVQLVADHYAPATSQPVGTLLVRGPYGRRFPFSLVFARIYAARGYHVVLQSVR
GTFGSGGVFEPMVNEAADGADTVAWLREQPWFTGRFGTIGLPYLGFTQWALLHDPPPE
LAAAVITVGPHDFRASVWGTGSFTVNDFLGWSDLVSHQEDPGRIRAGIRQLTAPRRVA
RTAATLPLGESARTLLGTGAPWFESWVEHTDRDDPFWDRLRFPAALDRVQVPVLLVGG
WQDIFLRQTLQQYRHLRDRGVHVALTVGPWTHTQMLTKGLATGARESLDWLDAHLGRA
PALRPSPVRVFVTGQGWRHLPDWPPATTERAWYLQPGGRLGESAPASGTPPATFRYHP
ADPTPTTGGPLLSSNGGYRDDSRLATRADVLCFTGAPLTHDLCVHGNPVVELVHSSDN
PYVDVFVRVSEVDAKGRSRNVSDGYRRLGDAPELVRVELDAIAHRFRADSRIRVLIAG
SWFPRYARNLGTPEPILTGRQLKPATHAVHFGRSRLLLPVG"
gene complement(3110167..3110523)
/gene="mazF9"
/gene_synonym="mt1"
/locus_tag="Rv2801c"
CDS complement(3110167..3110523)
/codon_start=1
/transl_table=11
/gene="mazF9"
/gene_synonym="mt1"
/locus_tag="Rv2801c"
/product="Toxin MazF9"
/note="Rv2801c, (MTCY16B7.42), len: 118 aa. MazF9,
toxin,part of toxin-antitoxin (TA) operon with Rv2801A
(See Pandey and Gerdes, 2005; Zhu et al., 2006), highly
similar to Q9RWK4|DR0662 conserved hypothetical protein
from Deinococcus radiodurans (115 aa), FASTA scores: opt:
306,E(): 2e-15, (43.95% identity in 116 aa overlap); and
similar to AAK78474|CAC0494 PEMK family of DNA-binding
proteins from Clostridium acetobutylicum (122 aa), FASTA
scores: opt: 217, E(): 7.3e-09, (33.35% identity in 117 aa
overlap); P96622|YDCE YDCE protein from Bacillus subtilis
(116 aa), FASTA scores: opt: 194, E(): 3.5e-07, (33.35%
identity in 117 aa overlap); Q9PHH8|XFA0027 plasmid
maintenance protein from Xylella fastidiosa (108 aa),
FASTA scores: opt: 188, E(): 9.1e-07, (40.85% identity in
115 aa overlap); etc. Also similar to
Q10867|YJ91_MYCTU|Rv1991c|MT2046|MTCY39.28 hypothetical
12.3 KDA protein from Mycobacterium tuberculosis (114
aa),FASTA scores: opt: 190, E(): 6.8e-07, (36.75% identity
in 117 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2801c"
/db_xref="EnsemblGenomes-Tr:CCP45600"
/db_xref="GOA:P71650"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="PDB:5HJZ"
/db_xref="UniProtKB/Swiss-Prot:P71650"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45600.1"
/translation="MMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRG
VITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQAEQIRSIATERLLRPIGRVSAAE
LAQLDEALKLHLDLWS"
gene complement(3110507..3110737)
/gene="mazE9"
/locus_tag="Rv2801A"
CDS complement(3110507..3110737)
/codon_start=1
/transl_table=11
/gene="mazE9"
/locus_tag="Rv2801A"
/product="Possible antitoxin MazE9"
/note="Rv2801A, len: 76 aa. Possible mazE9, antitoxin,
part of toxin-antitoxin (TA) operon with Rv2801c (See
Pandey and Gerdes, 2005; Zhu et al., 2006). This region is
a possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2801A"
/db_xref="EnsemblGenomes-Tr:CCP45601"
/db_xref="GOA:P0CL61"
/db_xref="UniProtKB/Swiss-Prot:P0CL61"
/protein_id="CCP45601.1"
/translation="MKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLE
DDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR"
gene complement(3110780..3111823)
/locus_tag="Rv2802c"
CDS complement(3110780..3111823)
/codon_start=1
/transl_table=11
/locus_tag="Rv2802c"
/product="Hypothetical arginine and alanine rich protein"
/note="Rv2802c, (MTCY16B7.41), len: 347 aa. Hypothetical
unknown arg-, ala-rich protein. C-terminus shows some
similarity with N-terminal part of hypothetical proteins
Q98K84|MLR1592 from Rhizobium loti (Mesorhizobium loti)
(104 aa), FASTA scores: opt: 138, E(): 0.12, (37.35%
identity in 91 aa overlap); and CAC47718|SMC03294 from
Rhizobium meliloti (Sinorhizobium meliloti) (114 aa),
FASTA scores: opt: 128, E(): 0.53, (31.4% identity in 86
aa overlap). Equivalent to AAK47191 from Mycobacterium
tuberculosis strain CDC1551 (357 aa) but shorter 10 aa.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2802c"
/db_xref="EnsemblGenomes-Tr:CCP45602"
/db_xref="InterPro:IPR018744"
/db_xref="UniProtKB/TrEMBL:P71649"
/protein_id="CCP45602.1"
/translation="MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQW
RQGRVDSLEQVVQANLSKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTG
EDAIERAYRTHWVSPELSERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAG
PLCLDCADLGHLVFLPSGDAALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEAL
ERAENECLADAEVRARRRERDEARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARH
AATRGSGRIGRSAAGRALDPEAVRLAVAASVRHIDTSFDELLMSGVDRETARHRVGEH
VEEVLRDWRATSR"
gene 3111822..3112289
/locus_tag="Rv2803"
CDS 3111822..3112289
/codon_start=1
/transl_table=11
/locus_tag="Rv2803"
/product="Conserved hypothetical protein"
/note="Rv2803, len: 155 aa. Conserved hypothetical
protein,similar to hypothetical proteins from other
organisms, and with some similarity to C-terminal part of
Rv0918|Z95210_12 hypothetical protein from Mycobacterium
tuberculosis (158 aa), FASTA scores: opt: 204, E(): 9e-07,
(42.35% identity in 85 aa overlap). Replaces original
2803c on other strand. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv2803"
/db_xref="EnsemblGenomes-Tr:CCP45603"
/db_xref="GOA:I6XFC2"
/db_xref="InterPro:IPR010985"
/db_xref="InterPro:IPR014795"
/db_xref="InterPro:IPR016547"
/db_xref="UniProtKB/TrEMBL:I6XFC2"
/protein_id="CCP45603.1"
/translation="MTCPSLVGLRTEAAELSYSDQPDALGVAMRERREQQNLVRPPRR
NASRRINTDQTSTKYVYITYMPETLTGRLNFRLSPEQEQALRHAAALTGQSLSGFVLS
AAVDHAHDLLARANRIELSEAAFRRFVAALDEPDEAAPELVRLARRKSRIPPH"
gene complement(3112465..3113094)
/locus_tag="Rv2804c"
CDS complement(3112465..3113094)
/codon_start=1
/transl_table=11
/locus_tag="Rv2804c"
/product="Hypothetical protein"
/note="Rv2804c, (MTCY16B7.39), len: 209 aa. Hypothetical
unknown protein, overlaps neighbouring orf
Rv2805|MTCY16B7.38c. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2804c"
/db_xref="EnsemblGenomes-Tr:CCP45604"
/db_xref="UniProtKB/TrEMBL:I6YEE9"
/protein_id="CCP45604.1"
/translation="MHDHQVLAARHAHQGPHVLQQRPGFVAEAPRPKATPVDLLGRAR
QPRAGQHLPRRRAAHPRGGHHRIQNLAVAPPHHRRQQQRGHSRRSIGSTSPSDDSASY
SQRPRDVADPPVEASTLEGQEAVVTVELGGAVVDGVDDQGAGAVVPGTGHGSDEGIEE
KIATETGALLLPVERQASEDEHWDRVGSGWPRPGRDGTRIRSMLPMASA"
gene 3112867..3113271
/locus_tag="Rv2805"
CDS 3112867..3113271
/codon_start=1
/transl_table=11
/locus_tag="Rv2805"
/product="Conserved hypothetical protein"
/note="Rv2805, (MTCY16B7.38c), len: 134 aa. Conserved
hypothetical protein, highly similar to N-terminal region
of downstream ORF P71644|Rv2807|MTCY16B7.36c conserved
hypothetical protein from Mycobacterium tuberculosis (384
aa), FASTA scores: opt: 525, E(): 6.4e-29, (78.2% identity
in 101 aa overlap). Also highly similar to N-terminus of
other proteins: Q9KK74 hypothetical 47.4 KDA protein from
Brevibacterium linens (418 aa), FASTA scores: opt:
480,E(): 8.8e-26, (64.15% identity in 106 aa overlap);
AAK40065 Rv3128c-like protein from Mycobacterium celatum
(423 aa),FASTA scores: opt: 218, E(): 1.2e-07, (46.05%
identity in 89 aa overlap); Q981U5|MLR9230 from Rhizobium
loti (Mesorhizobium loti) (504 aa), FASTA scores: opt:
131, E(): 0.15, (29.4% identity in 126 aa overlap).
Overlaps neighbouring ORF Rv2804c|MTCY16B7.39. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2805"
/db_xref="EnsemblGenomes-Tr:CCP45605"
/db_xref="UniProtKB/TrEMBL:P71646"
/protein_id="CCP45605.1"
/translation="MGRGNGKILDPVVATTGMGRSTARQMLTGPRLPGPAEQVDGRSL
RPRGFSDEARALLEHVWALMGMPCGKYLVVMHDLWLPLLTAAGDLDKPLVTEASVAEL
KATALPGANRMPHWAAGTLPDGFPARAVRTRT"
gene 3113268..3113459
/locus_tag="Rv2806"
CDS 3113268..3113459
/codon_start=1
/transl_table=11
/locus_tag="Rv2806"
/product="Possible membrane protein"
/note="Rv2806, (MTCY16B7.37c), len: 63 aa. Possible
membrane protein, sharing no homology. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2806"
/db_xref="EnsemblGenomes-Tr:CCP45606"
/db_xref="GOA:I6YAA5"
/db_xref="UniProtKB/TrEMBL:I6YAA5"
/protein_id="CCP45606.1"
/translation="MKTNPRYGPAFYSVMTVLFLALFVLNVCTHGSTLGLISTGGLAV
LMGYIGYRGWSGKRHINRQ"
gene 3113658..3114812
/locus_tag="Rv2807"
CDS 3113658..3114812
/codon_start=1
/transl_table=11
/locus_tag="Rv2807"
/product="Conserved hypothetical protein"
/note="Rv2807, (MTCY16B7.36c), len: 384 aa. Conserved
hypothetical protein, highly similar, but shorter 35 aa,
to Q9KK74 hypothetical 47.4 KDA protein from
Brevibacterium linens (418 aa), FASTA scores: opt: 1865,
E(): 9.4e-116,(69.75% identity in 380 aa overlap); and
with similarity with other hypothetical proteins or
transposases e.g. Q981U5|MLR9230 protein from Rhizobium
loti (Mesorhizobium loti) (504 aa), FASTA scores: opt:
636,, (36.05% identity in 377 aa overlap); CAC47689
putative transposase for insertion sequence ISRM18 from
Rhizobium meliloti (Sinorhizobium meliloti) (507 aa),
FASTA scores: opt: 553,E(): 6.6e-29, (33.5% identity in
370 aa overlap); etc. Also similar to Rv3128c|MTCY164.38c
(336 aa) (47.2% identity in 339 aa overlap); and high
similarity at N-terminal region with Rv2805|MTCY16B7.38c
(79.2% identity in 101 aa overlap). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2807"
/db_xref="EnsemblGenomes-Tr:CCP45607"
/db_xref="GOA:P71644"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR036397"
/db_xref="UniProtKB/TrEMBL:P71644"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45607.1"
/translation="MVSTTGMGRSTARRMLTGPGLPEPAEQVDGRRLRARGFSDDARA
LLEHVWALMGMPCGKYLVVMLELWLPLEAAAGDLDKPFATEAAVAELKAMSAATVDRY
LKPARERMRIKGISTTKPSPLLRNSITIHTCSDEAPKVPGVIEADTVAHCGPSLIGEF
ARTLTMTDLVTGWTENASIRNNAAKWILEGIKECQQRFPFPMTVFDSDCGGEFINHDV
AGWLQARDIAQTRSRPYQKNDQAHVESKNNHVVRKHAFYWRYDTGEELELLNRLWPLV
SLRCNFFTPTKKPVGYTSTVNGRRKRIYDKPATPWQRLQASGVLDAQQLSTVAARIEG
FNPADLTRQINAIQMQLLDLAKTKTEALATARHIDLQSLQPSINRLAKAK"
gene 3115046..3115303
/locus_tag="Rv2808"
CDS 3115046..3115303
/codon_start=1
/transl_table=11
/locus_tag="Rv2808"
/product="Hypothetical protein"
/note="Rv2808, (MTCY16B7.35c), len: 85 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2808"
/db_xref="EnsemblGenomes-Tr:CCP45608"
/db_xref="UniProtKB/TrEMBL:P71643"
/protein_id="CCP45608.1"
/translation="MSNVLDAISTEHRPVIEQELENRNPALFDELRRTEKPTNEQSDA
VIDVLSDALMKTFGPDWVPNDYGLKIERAIDAYLETWPIYR"
gene 3115408..3115719
/locus_tag="Rv2809"
CDS 3115408..3115719
/codon_start=1
/transl_table=11
/locus_tag="Rv2809"
/product="Hypothetical protein"
/note="Rv2809, (MTCY16B7.34c), len: 103 aa (questionable
ORF). Hypothetical unknown protein. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2809"
/db_xref="EnsemblGenomes-Tr:CCP45609"
/db_xref="UniProtKB/TrEMBL:I6YEF3"
/protein_id="CCP45609.1"
/translation="MTYAARDDTTLPKLLAQMRWVVLVDKRQLAVLLLENEGPVASAT
DTLDTRGDSDYENQPVDAVERLCRRLADQAVRQWGFMQGLKQKLGPGVDVRMKLVEWN
R"
gene complement(3115741..>3116142)
/locus_tag="Rv2810c"
CDS complement(3115741..>3116142)
/codon_start=1
/transl_table=11
/locus_tag="Rv2810c"
/product="Probable transposase"
/note="Rv2810c, (MTCY16B7.33), len: 133 aa. Probable
transposase for IS1555, similar to C-terminal domain of
transposases for defective IS1555 e.g. Q9LCS0|TNPA
transposase from Arthrobacter sp. TM1 (435 aa), FASTA
scores: opt: 294, E(): 1.8e-13, (55.1% identity in 98 aa
overlap); Q50440|TNPA insertion element TNPR and TNPA gene
from Mycobacterium smegmatis (413 aa), FASTA scores: opt:
274, E(): 4.7e-12, (56.25% identity in 96 aa overlap);
etc. This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2810c"
/db_xref="EnsemblGenomes-Tr:CCP45610"
/db_xref="InterPro:IPR002560"
/db_xref="UniProtKB/TrEMBL:P71641"
/protein_id="CCP45610.1"
/translation="PLRLQAHTGGPPVALRQETTGGPSPTNDLITEPPRHYKQQTRVR
QAPALLTVSAGTGVPVVLEELAKLGRTLWRCRHDVLAYFDHHASNGPTEAINGRLEAL
CRNALGFRNLTHYRIRSLLHCGNLAQLIHAL"
mobile_element complement(3115744..3116142)
/mobile_element_type="insertion sequence:IS1555'"
/locus_tag="Rv2810c"
/note="IS1555', len: 399 nt. Probable defective Insertion
sequence element, IS1555. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 3116139..3116747
/locus_tag="Rv2811"
CDS 3116139..3116747
/codon_start=1
/transl_table=11
/locus_tag="Rv2811"
/product="Conserved hypothetical protein"
/note="Rv2811, (MTCY16B7.32c), len: 202 aa. Conserved
hypothetical protein. C-terminus equivalent to C-terminus
of AAK47198|MT2878 hypothetical 17.7 KDA protein
Mycobacterium tuberculosis strain CDC1551 (178 aa), FASTA
scores: opt: 609, E(): 1.5e-32, (61.0% identity in 182 aa
overlap); and C-terminus highly similar to
P72038|Rv3771c|MTCY13D12.05c hypothetical 11.3 KDA protein
from Mycobacterium tuberculosis (108 aa), FASTA scores:
opt: 465, E(): 2.8e-23, (73.6% identity in 106 aa
overlap). Also some similarity with
P71962|Rv2665|MTCY441.34 hypothetical 10.5 KDA protein
from Mycobacterium tuberculosis (93 aa), FASTA scores:
opt: 153, E(): 0.0057,(39.05% identity in 64 aa overlap);
and Q9A6W6|CC1966 hypothetical protein CC1966 from
Caulobacter crescentus (189 aa), FASTA scores: opt: 115,
E(): 2.6, (39.4% identity in 104 aa overlap). This region
is a possible MT-complex-specific genomic island (See Becq
et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2811"
/db_xref="EnsemblGenomes-Tr:CCP45611"
/db_xref="UniProtKB/TrEMBL:P71640"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45611.1"
/translation="MVTVEADVDQVERRLAAGELSCPSCGGVLAGWGRARSRQLRGPA
GPVELCPRRSRCTGCGVTHVLLPVSALLRRADTAAVIVSALAAKATSRVGFRRIATDV
ARPAETVRGWLRRFAERVEAVRSVFTVWLCAVDADPVMPDAGGGGFVDAVVAIGALAA
AIGRRFSLPTVSLAETAVAVSGGRLLAPGWPGEWVQHESTLP"
mobile_element 3116817..3118225
/mobile_element_type="insertion sequence:IS1604"
/note="IS1604, len: 1409 nt. Insertion sequence IS1604.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
gene 3116818..3118227
/locus_tag="Rv2812"
CDS 3116818..3118227
/codon_start=1
/transl_table=11
/locus_tag="Rv2812"
/product="Probable transposase"
/note="Rv2812, (MTCY16B7.31c), len: 469 aa. Probable
transposase for IS1604, similar to putative transposases
and hypothetical proteins e.g. Q9EZM2|putative transposase
from Mycobacterium paratuberculosis (395 aa), FASTA
scores: opt: 329, E(): 3e-13, (27.05% identity in 362 aa
overlap); CAC46499 putative transposase protein from
Rhizobium meliloti (Sinorhizobium meliloti) (390 aa),
FASTA scores: opt: 327, E(): 3.9e-13, (30.5% identity in
367 aa overlap); etc. Contains possible helix-turn-helix
motif at aa 50-71 (Score 1140, +3.07 SD). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2812"
/db_xref="EnsemblGenomes-Tr:CCP45612"
/db_xref="GOA:P71639"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR015378"
/db_xref="InterPro:IPR036397"
/db_xref="UniProtKB/TrEMBL:P71639"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45612.1"
/translation="MAVGDDEEKVRAERARAIGLFRYQLIWEAADAAHSTKQRGKMVR
ELASREHTDPFGRRVRISRQTIDRWIRGWRAGGFDALVPNPRQCTPRTPAEVLELAVA
LRRENPQRTAAAIRRILRTQLGWAPDERTLQRNFHRLGLTGATTGSAPAVFGRFEAEH
PNALWTGDVLHGIRIDLRKTYLFAFLDDHSRLVPGYRWGHAEDTVRLAAALRPALASR
GVPNAVYVDNGSPYVDAWLLRACAKLGVRLVHSTPGRPQGRGKIERFFRTVREQFLVE
ITGEPDVVGRHYVADLAELNRLFTAWVETVYHRSVHSETGQTPLARWSAGGPIPLPAP
ETLTEAFLWEEHRRVTKTATVSLHGNRYEIDPALVGRKVELVFDPFDLTRIEVRLAGA
PMRRAIPYHIGRHSHPKAKPETPTAPPKPSGIDYAQLIETAHAAELARGVNYTALTGA
ADQIPGQLDLLTGQEAQPK"
gene 3118224..3119036
/locus_tag="Rv2813"
CDS 3118224..3119036
/codon_start=1
/transl_table=11
/locus_tag="Rv2813"
/product="Conserved hypothetical protein"
/note="Rv2813, (MTCY16B7.30c), len: 270 aa. Conserved
hypothetical protein, similar to various proteins (notably
secreted proteins) e.g. Q9ZFL2 hypothetical 30.4 KDA
protein from Bacillus stearothermophilus (266 aa), FASTA
scores: opt: 518, E(): 1.4e-26, (33.85% identity in 266 aa
overlap); P45754|GSPA_AERHY|EXEA general secretion pathway
protein from Aeromonas hydrophila (547 aa), FASTA scores:
opt: 386, E(): 1.1e-17, (32.05% identity in 265 aa
overlap); Q9KPC7|VC2445 general secretion pathway protein
A from Vibrio cholerae (529 aa), FASTA scores: opt: 366,
E(): 2.2e-16, (31.1% identity in 270 aa overlap);
Q56674|VC0403 mannose-sensitive hemagglutinin D from
Vibrio cholerae (281 aa), FASTA scores: opt: 317, E():
2.1e-13, (27.85% identity in 262 aa overlap); etc. Also
highly similar to AAK40072 Rv2813-like protein from
Mycobacterium celatum (270 aa),FASTA scores: opt: 1628,
E(): 2.8e-99, (90.75% identity in 270 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A (P-loop).
This region is a possible MT-complex-specific genomic
island (See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2813"
/db_xref="EnsemblGenomes-Tr:CCP45613"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:I6XFD1"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45613.1"
/translation="MMHKLISYYGFSRMPFGRDLAPGMLHRHSAHNEAVARIGWCIAD
RRIGVITGEVGAGKTVAVRAALASLDRSRHTIIYLPDPTVGVQGIHHRIVASLGGQPL
THHATLAPQAADALAAEQAERGRTPVVVVEEAHLLGYDQLEALRLLTNHDLDSSSPFA
CLLIGQPTLRRRMKLGVLAALDQRIGLRYAMPPMTDTNTGSYLRHHLKLAGRDDALFS
DDAIGLIHQTSRGYPRAVNNLALQALVAAFAADKAIVDESTTRTAIAEVTAD"
repeat_region complement(3119185..3123576)
/note="4392 bp direct repeat region. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
repeat_region complement(3119185..3119220)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119259..3119294)
/note="36 bp direct repeat, 35 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119335..3119370)
/note="36 bp direct repeat, 35 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119411..3119446)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119484..3119519)
/note="36 bp direct repeat, 35 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119556..3119591)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119627..3119662)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119701..3119736)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119777..3119812)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119848..3119883)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119921..3119956)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3119995..3120030)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3120068..3120103)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3120141..3120176)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3120213..3120248)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3120285..3120320)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3120359..3120394)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3120433..3120468)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3120504..3120523)
/note="20 bp partial direct repeat,
CCCCGAGAGGGGACGGAAAC,of sequence
GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
mobile_element complement(3120523..3121897)
/mobile_element_type="insertion sequence:IS6110-11"
/note="IS6110-11, len: 1375 nt. Insertion sequence IS6110.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
gene complement(3120566..>3121552)
/locus_tag="Rv2814c"
CDS complement(3120566..>3121552)
/codon_start=1
/transl_table=11
/locus_tag="Rv2814c"
/product="Probable transposase"
/note="Rv2814c, (MTCY16B7.29), len: 328 aa. Probable
transposase subunit for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv2814c and Rv2815c, the
sequence UUUUAAAG (directly upstream of Rv2814c) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (+ 16
aa). This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2814c"
/db_xref="EnsemblGenomes-Tr:CCP45614"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP45614.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
gene complement(3121501..3121827)
/locus_tag="Rv2815c"
CDS complement(3121501..3121827)
/codon_start=1
/transl_table=11
/locus_tag="Rv2815c"
/product="Probable transposase"
/note="Rv2815c, (MTCY16B7.28), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv2814c and
Rv2815c, the sequence UUUUAAAG (directly upstream of
Rv2814c) maybe responsible for such a frameshifting event
(see McAdam et al., 1990). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2815c"
/db_xref="EnsemblGenomes-Tr:CCP45615"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP45615.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
repeat_region complement(3121882..3121897)
/note="16 bp partial direct repeat, GTCGTCAGACCCAAAA, of
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3121938..3121973)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122013..3122048)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122086..3122121)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122158..3122193)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122230..3122265)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122303..3122338)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122375..3122410)
/note="36 bp direct repeat, 32 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122436..3122471)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122513..3122548)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122585..3122620)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122661..3122696)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122738..3122773)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122811..3122846)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122882..3122917)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3122955..3122990)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123029..3123064)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123102..3123137)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123173..3123208)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123248..3123283)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123318..3123353)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123390..3123425)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123467..3123502)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
repeat_region complement(3123541..3123576)
/note="36 bp direct repeat, 36 out of 36 bp identical to
sequence GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC. This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
gene complement(3123625..3123966)
/locus_tag="Rv2816c"
CDS complement(3123625..3123966)
/codon_start=1
/transl_table=11
/locus_tag="Rv2816c"
/product="Conserved hypothetical protein"
/note="Rv2816c, (MTCY16B7.27), len: 113 aa. Conserved
hypothetical protein, highly similar in part to N-terminus
of several proteins e.g. O28403|AF1876 conserved
hypothetical protein from Archaeoglobus fulgidus (94
aa),FASTA scores: opt: 137, E(): 0.0022, (47.55% identity
in 61 aa overlap); Q97Y85|SSO8090 hypothetical protein
from Sulfolobus solfataricus (88 aa), FASTA scores: opt:
124,E(): 0.02, (37.3% identity in 59 aa overlap); etc.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2816c"
/db_xref="EnsemblGenomes-Tr:CCP45616"
/db_xref="GOA:P9WPJ3"
/db_xref="InterPro:IPR019199"
/db_xref="InterPro:IPR021127"
/db_xref="UniProtKB/Swiss-Prot:P9WPJ3"
/protein_id="CCP45616.1"
/translation="MPTRSREEYFNLPLKVDESSGTIGKMFVLVIYDISDNRRRASLA
KILAGFGYRVQESAFEAMLTKGQLAKLVARIDRFAIDCDNIRIYKIRGVAAVTFYGRG
RLVSAEEFVFF"
gene complement(3123967..3124983)
/locus_tag="Rv2817c"
CDS complement(3123967..3124983)
/codon_start=1
/transl_table=11
/locus_tag="Rv2817c"
/product="Conserved hypothetical protein"
/note="Rv2817c, (MTCY16B7.26), len: 338 aa. Conserved
hypothetical protein, showing similarity with
O30236|AF2435 conserved hypothetical protein from
Archaeoglobus fulgidus (322 aa), FASTA scores: opt: 397,
E(): 2.4e-19, (28.2% identity in 298 aa overlap);
Q9KFX9|BH0341 hypothetical protein from Bacillus
halodurans (343 aa), FASTA scores: opt: 337, E(): 2.8e-15,
(27.35% identity in 300 aa overlap); Q9X2B7|TM1797
conserved hypothetical protein from Thermotoga maritima
(319 aa), FASTA scores: opt: 321, E(): 3.3e-14, (26.5%
identity in 268 aa overlap); etc. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2817c"
/db_xref="EnsemblGenomes-Tr:CCP45617"
/db_xref="GOA:P9WPJ5"
/db_xref="InterPro:IPR002729"
/db_xref="InterPro:IPR042206"
/db_xref="InterPro:IPR042211"
/db_xref="UniProtKB/Swiss-Prot:P9WPJ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45617.1"
/translation="MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFG
RPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSYAPRLRQQVHRTDDPAFCLS
LSKRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAK
AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGF
LHQDSRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREAT
RSIARAFGNRIARTATYIKGDPHRYTFQYALDLQLQSLVRVIEAGHPSRLVDIDITSE
PSGA"
gene complement(3124996..3126144)
/locus_tag="Rv2818c"
CDS complement(3124996..3126144)
/codon_start=1
/transl_table=11
/locus_tag="Rv2818c"
/product="Hypothetical protein"
/note="Rv2818c, (MTCY16B7.25), len: 382 aa. Hypothetical
unknown protein, equivalent to AAK47210 from Mycobacterium
tuberculosis strain CDC1551 (430 aa) but shorter 48 aa.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2818c"
/db_xref="EnsemblGenomes-Tr:CCP45618"
/db_xref="GOA:P71635"
/db_xref="InterPro:IPR013489"
/db_xref="UniProtKB/Swiss-Prot:P71635"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45618.1"
/translation="MLFLSAEIAAFENADRRYSAAITRLAPETDVRIVTYTNPSVHRF
DLFVPVFRNHLVELSAEFPDRTILLNTSSGTPAMQAALVAINVFGIPRTTAVQVSTPA
RALSKPGDRESPDAYDLELMWDANDDNQPGAPNRCFEATSAALGALLERANLKQLIVS
YDYSAAVTIAADSRLPDQVSNLIRGAMHRSRLEHLVAPKFFKDTAFTYDPANKVAEYI
SALALLAKREQWAEFARSATPAITIVLRAAVAKHLPEDRYLDDMGRVDRRKLEREPEI
RCALKHPPKSPNAEWYLYTKDWLALLRQFAPDRVGALEVLGRFESRVRNTAAHEIVSI
SEDRITKDGGLLPEQLLKILARETGADLTLYDRLNDEIIRQIDMAPLG"
gene complement(3126240..3127367)
/locus_tag="Rv2819c"
CDS complement(3126240..3127367)
/codon_start=1
/transl_table=11
/locus_tag="Rv2819c"
/product="Hypothetical protein"
/note="Rv2819c, (MTCY16B7.23), len: 375 aa. Hypothetical
unknown protein (see citations below). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2819c"
/db_xref="EnsemblGenomes-Tr:CCP45619"
/db_xref="GOA:P9WJF5"
/db_xref="InterPro:IPR005537"
/db_xref="InterPro:IPR010173"
/db_xref="UniProtKB/Swiss-Prot:P9WJF5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45619.1"
/translation="MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDME
LLYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEP
RRASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQ
PVRVPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDL
LICQKMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAE
TAASVNQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGK
VVKHVDKTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE"
gene complement(3127364..3128272)
/locus_tag="Rv2820c"
CDS complement(3127364..3128272)
/codon_start=1
/transl_table=11
/locus_tag="Rv2820c"
/product="Hypothetical protein"
/note="Rv2820c, (MTCY16B7.22), len: 302 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2820c"
/db_xref="EnsemblGenomes-Tr:CCP45620"
/db_xref="GOA:P9WJF7"
/db_xref="InterPro:IPR005510"
/db_xref="InterPro:IPR040932"
/db_xref="UniProtKB/Swiss-Prot:P9WJF7"
/protein_id="CCP45620.1"
/translation="MNSRLFRFDFDRTHFGDHGLESSTISCPADTLYSALCVEALRMG
GQQLLGELVACSTLRLTDLLPYVGPDYLVPKPLHSVRSDGSSMQKKLAKKIGFLPAAQ
LGSFLDGTADLKELAARQTKIGVHAVSAKAAIHNGKKDADPYRVGYFRFELDAGLWLL
ATGSESELGLLTRLLKGISALGGERTSGFGAFNLTESEAPAALTPTVDAASLMTLTTS
LPTDDELEAALAGATYRLVKRSGFVASSTYADMPLRKRDIYKFAAGSVFSRPFQGGIL
DVSLGGNHPVYSYARPLFLALPESAA"
gene complement(3128253..3128963)
/locus_tag="Rv2821c"
CDS complement(3128253..3128963)
/codon_start=1
/transl_table=11
/locus_tag="Rv2821c"
/product="Conserved hypothetical protein"
/note="Rv2821c, (MTCY16B7.21), len: 236 aa. Conserved
hypothetical protein, similar to several hypothetical
proteins e.g. Q9X2C9|TM1809 conserved hypothetical protein
from Thermotoga maritima (247 aa), FASTA scores: opt:
318,E(): 8.2e-15, (39.45% identity in 213 aa overlap);
O27152|MTH1080 conserved hypothetical protein from
Methanothermobacter thermautotrophicus (245 aa), FASTA
scores: opt: 294, E(): 3.9e-13, (34.8% identity in 224 aa
overlap); BAB59251|TVG0114661 hypothetical protein from
Thermoplasma volcanium (229 aa), FASTA scores: opt:
252,E(): 3.3e-10, (33.8% identity in 225 aa overlap); etc.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2821c"
/db_xref="EnsemblGenomes-Tr:CCP45621"
/db_xref="GOA:P9WJF9"
/db_xref="InterPro:IPR005537"
/db_xref="InterPro:IPR013412"
/db_xref="UniProtKB/Swiss-Prot:P9WJF9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45621.1"
/translation="MTTSYAKIEITGTLTVLTGLQIGAGDGFSAIGAVDKPVVRDPLS
RLPMIPGTSLKGKVRTLLSRQYGADTETFYRKPNEDHAHIRRLFGDTEEYMTGRLVFR
DTKLTNKDDLEARGAKTLTEVKFENAINRVTAKANLRQMERVIPGSEFAFSLVYEVSF
GTPGEEQKASLPSSDEIIEDFNAIARGLKLLELDYLGGSGTRGYGQVKFSNLKARAAV
GALDGSLLEKLNHELAAV"
gene complement(3128973..3129347)
/locus_tag="Rv2822c"
CDS complement(3128973..3129347)
/codon_start=1
/transl_table=11
/locus_tag="Rv2822c"
/product="Hypothetical protein"
/note="Rv2822c, (MTCY16B7.20), len: 124 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2822c"
/db_xref="EnsemblGenomes-Tr:CCP45622"
/db_xref="GOA:P9WJG1"
/db_xref="InterPro:IPR010149"
/db_xref="UniProtKB/Swiss-Prot:P9WJG1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45622.1"
/translation="MSVIQDDYVKQAEVIRGLPKKKNGFELTTTQLRVLLSLTAQLFD
EAQQSANPTLPRQLKEKVQYLRVRFVYQSGREDAVKTFVRNAKLLEALEGIGDSRDGL
LRFCRYMEALAAYKKYLDPKDK"
gene complement(3129344..3131773)
/locus_tag="Rv2823c"
CDS complement(3129344..3131773)
/codon_start=1
/transl_table=11
/locus_tag="Rv2823c"
/product="Conserved protein"
/note="Rv2823c, (MTCY16B7.19), len: 809 aa. Conserved
protein, similar in part to others e.g.
Q9X2D1|TM1811Thermotoga maritima (717 aa), FASTA scores:
opt: 401, E(): 3.6e-18, (27.15% identity in 773 aa
overlap); O27154|MTH1082 conserved hypothetical protein
from Methanothermobacter thermautotrophicus (822 aa),
FASTA scores: opt: 306, E(): 6e-12, (25.55% identity in
872 aa overlap); Q59066|MJ1672 hypothetical protein from
Methanococcus jannaschii (800 aa), FASTA scores: opt:
302,E(): 1.1e-11, (24.9% identity in 812 aa overlap); etc.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2823c"
/db_xref="EnsemblGenomes-Tr:CCP45623"
/db_xref="GOA:P71629"
/db_xref="InterPro:IPR000160"
/db_xref="InterPro:IPR003607"
/db_xref="InterPro:IPR013408"
/db_xref="InterPro:IPR041062"
/db_xref="UniProtKB/Swiss-Prot:P71629"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45623.1"
/translation="MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVW
LRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYN
IAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPS
PRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDV
SLFDHLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDF
IYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTE
SARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYS
GLYRELSEQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKC
SLCQALTAASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRR
RYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHG
FMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYS
GGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDL
EDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLL
ELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHL
YIYRTRKEESE"
gene complement(3131770..3132714)
/locus_tag="Rv2824c"
CDS complement(3131770..3132714)
/codon_start=1
/transl_table=11
/locus_tag="Rv2824c"
/product="Hypothetical protein"
/note="Rv2824c, (MTCY16B7.18), len: 314 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2824c"
/db_xref="EnsemblGenomes-Tr:CCP45624"
/db_xref="GOA:P9WPJ1"
/db_xref="InterPro:IPR010156"
/db_xref="InterPro:IPR019267"
/db_xref="UniProtKB/Swiss-Prot:P9WPJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45624.1"
/translation="MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVG
FSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVP
VNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRS
LEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAI
VDGEEPDPGLIAEFGQSVRLSAFRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYI
AALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP"
gene complement(3132892..3133539)
/locus_tag="Rv2825c"
CDS complement(3132892..3133539)
/codon_start=1
/transl_table=11
/locus_tag="Rv2825c"
/product="Conserved hypothetical protein"
/note="Rv2825c, (MTCY16B7.17), len: 215 aa. Conserved
hypothetical protein, similar to Q9RY53|DR0097 conserved
hypothetical protein from Deinococcus radiodurans (189
aa),FASTA scores: opt: 261, E(): 8e-11, (33.5% identity in
176 aa overlap); and shows some similarity with N-terminus
of O27278|MTH1210 MRR restriction system related protein
from Methanothermobacter thermautotrophicus (340 aa),
FASTA scores: opt: 133, E(): 0.091, (28.55% identity in
112 aa overlap). Equivalent to AAK47217 from Mycobacterium
tuberculosis strain CDC1551 (246 aa) but shorter 31 aa;
and equivalent to upstream ORF P71624|Rv2828c|MTCY16B7.14
from Mycobacterium tuberculosis strain H37Rv (alias
AAK47221 from strain CDC1551) (181 aa), FASTA scores: opt:
1169,E(): 8.5e-74, (98.35% identity in 181 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2825c"
/db_xref="EnsemblGenomes-Tr:CCP45625"
/db_xref="InterPro:IPR008307"
/db_xref="InterPro:IPR014923"
/db_xref="UniProtKB/TrEMBL:P71627"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45625.1"
/translation="MKLPGAKRLGDDRRPLGTLRCWRHSDIGPARGIVVTPALKEWSA
AVHALLDGRQTVLLRKGGIGEKRFEVAAHEFLLFPTVAHSHAERVRPEHRDLLGPAAA
DSTDECVLLRAAAKVVAALPVNRPEGLDAIEDLHIWTAESVRADRLDFRPKHKLAVLV
VSAIPLAEPVRLARRPEYGGCTSWVQLPVTPTLAAPVHDEAALAEVAARVREAVG"
gene complement(3133709..3134593)
/locus_tag="Rv2826c"
CDS complement(3133709..3134593)
/codon_start=1
/transl_table=11
/locus_tag="Rv2826c"
/product="Hypothetical protein"
/note="Rv2826c, (MTCY16B7.16), len: 294 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2826c"
/db_xref="EnsemblGenomes-Tr:CCP45626"
/db_xref="GOA:P71626"
/db_xref="InterPro:IPR014942"
/db_xref="UniProtKB/TrEMBL:P71626"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45626.1"
/translation="MAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGD
NRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVVLEVCELIDGARVGGFEFGVQST
RGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRG
TRPLRVEDVLAARSEHDFQPDSIGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAA
CDERHRREVENALAVLRS"
gene complement(3134596..3135483)
/locus_tag="Rv2827c"
CDS complement(3134596..3135483)
/codon_start=1
/transl_table=11
/locus_tag="Rv2827c"
/product="Hypothetical protein"
/note="Rv2827c, (MTCY16B7.15), len: 295 aa. Hypothetical
unknown protein, equivalent to AAK47219 from Mycobacterium
tuberculosis strain CDC1551 (315 aa) but shorter 20 aa."
/db_xref="EnsemblGenomes-Gn:Rv2827c"
/db_xref="EnsemblGenomes-Tr:CCP45627"
/db_xref="InterPro:IPR018547"
/db_xref="InterPro:IPR025159"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P71625"
/protein_id="CCP45627.1"
/translation="MVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGC
GRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLA
GASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLER
LLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAP
EYQLVDELVVPLLRVIGKA"
gene complement(3135788..3136333)
/locus_tag="Rv2828c"
CDS complement(3135788..3136333)
/codon_start=1
/transl_table=11
/locus_tag="Rv2828c"
/product="Conserved hypothetical protein"
/note="Rv2828c, (MTCY16B7.14), len: 181 aa. Conserved
hypothetical protein, similar to Q9RY53|DR0097 conserved
hypothetical protein from Deinococcus radiodurans (189
aa),FASTA scores: opt: 267, E(): 1.9e-11, (34.1% identity
in 176 aa overlap); and shows some similarity with
N-terminus of O27278|MTH1210 MRR restriction system
related protein from Methanothermobacter
thermautotrophicus (340 aa), FASTA scores: opt: 133, E():
0.07, (28.55% identity in 112 aa overlap). Also equivalent
to downstream ORF P71627|Rv2825c|MTCY16B7.17 from
Mycobacterium tuberculosis strain H37Rv (alias AAK47217
from strain CDC1551, 246 aa) (215 aa), FASTA scores: opt:
1173, E(): 8.3e-75, (98.9% identity in 181 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2828c"
/db_xref="EnsemblGenomes-Tr:CCP45628"
/db_xref="InterPro:IPR008307"
/db_xref="InterPro:IPR014923"
/db_xref="UniProtKB/TrEMBL:I6X5G8"
/protein_id="CCP45628.1"
/translation="MTPALKEWSAAVHALLDGRQTVLLRKGGIGEKRFEVAAHEFLLF
PTVAHSHAERVRPEHRDLLGPAAADSTDECVLLRAAAKVVAALPVNRPEGLDAIEDLH
IWTAESVRADRLDFRPKHRLAVLVVSAIPLAEPVRLARTPEYGGCTSWVQLPVTPTLA
APVHDEAALAEVAARVREAVG"
gene complement(3136330..3136599)
/locus_tag="Rv2828A"
CDS complement(3136330..3136599)
/codon_start=1
/transl_table=11
/locus_tag="Rv2828A"
/product="Conserved hypothetical protein"
/note="Rv2828A, len: 89 aa. Conserved hypothetical
protein,present in many mycobacteria. Equivalent to
BCG2848c and Mb2852A (100% identity to both in 89 aa
overlap)"
/db_xref="EnsemblGenomes-Gn:Rv2828A"
/db_xref="EnsemblGenomes-Tr:CCP45629"
/db_xref="InterPro:IPR018735"
/db_xref="UniProtKB/TrEMBL:I6YAC9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45629.1"
/translation="MCRNITELRGLQPPATPVEIAAAARQYVRKVSGITHPSAATAEA
FEAAVAEVTATTTRLLDALPPRRQPPKTVPPLRRPDVAARLAGSR"
gene complement(3136620..3137012)
/gene="vapC22"
/locus_tag="Rv2829c"
CDS complement(3136620..3137012)
/codon_start=1
/transl_table=11
/gene="vapC22"
/locus_tag="Rv2829c"
/product="Possible toxin VapC22"
/note="Rv2829c, (MTCY16B7.13), len: 130 aa. Possible
vapC22, toxin, part of toxin-antitoxin (TA) operon with
Rv2830c, contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Conserved hypothetical protein
similar to AAK65872|SMA2253 conserved hypothetical protein
from Rhizobium meliloti (Sinorhizobium meliloti) (125
aa),FASTA scores: opt: 171, E(): 7.7e-05, (34.9% identity
in 129 aa overlap); and shows some similarity with other
proteins e.g. Q9AH69 hypothetical 14.7 KDA protein from
Neisseria meningitidis (128 aa), FASTA scores: opt:
148,E(): 0.0031, (28.1% identity in 121 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2829c"
/db_xref="EnsemblGenomes-Tr:CCP45630"
/db_xref="GOA:P71623"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="InterPro:IPR041705"
/db_xref="UniProtKB/Swiss-Prot:P71623"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45630.1"
/translation="MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFE
LAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSVAATAVALPSSFPGDPADRLIYA
TAIEHGWRLVTKDRRLRSHRHPRPVTVW"
gene complement(3137009..3137224)
/gene="vapB22"
/locus_tag="Rv2830c"
CDS complement(3137009..3137224)
/codon_start=1
/transl_table=11
/gene="vapB22"
/locus_tag="Rv2830c"
/product="Possible antitoxin VapB22"
/note="Rv2830c, (MTCY16B7.12), len: 71 aa. Possible
vapB22,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2829c, (See Arcus et al., 2005; Pandey and Gerdes,
2005). Similar to others in Mycobacterium tuberculosis
e.g. Z97182|MTCY19H5.26|Rv0596c Hypothetical protein (85
aa),FASTA scores: opt: 88, E(): 1.3, (41.7% identity in 36
aa overlap); and to PHD_BPP1|Q06253 bacteriophage P1 phd
gene (73 aa), FASTA scores: opt: 79, E(): 3.8, (35.9%
identity in 39 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2830c"
/db_xref="EnsemblGenomes-Tr:CCP45631"
/db_xref="GOA:P71622"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:P71622"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45631.1"
/translation="MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHAL
KGRFSGVAMAAADDDELFTTGVSWNVS"
gene 3137271..3138020
/gene="echA16"
/locus_tag="Rv2831"
CDS 3137271..3138020
/codon_start=1
/transl_table=11
/gene="echA16"
/locus_tag="Rv2831"
/product="Probable enoyl-CoA hydratase EchA16 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv2831, (MTCY16B7.11c), len: 249 aa. Probable
echA16, enoyl-CoA hydratase, similar to others e.g.
O23468|AT4G16210 from Arabidopsis thaliana (Mouse-ear
cress) (244 aa), FASTA scores: opt: 491, E():
7.3e-25,(42.1% identity in 190 aa overlap); Q98LI4|MLL1009
from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA
scores: opt: 491, E(): 7.6e-25, (40.75% identity in 248 aa
overlap); O07137|ECH8_MYCLE|ML2402|MLCB1306.05c from
Mycobacterium leprae (257 aa), FASTA scores: opt: 478,
E(): 5.3e-24, (38.05% identity in 226 aa overlap);
P76082|PAAF_ECOLI|B1393 from scherichia coli strain K12
(255 aa), FASTA scores: opt: 439, E(): 1.9e-21, (37.55%
identity in 221 aa overlap); etc. Also similar to
O53418|ECH8_MYCTU|ECHA8|Rv1070c|MT1100|MTV017.23c from
Mycobacterium tuberculosis (257 aa), FASTA scores: opt:
471, E(): 1.5e-23, (38.05% identity in 226 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2831"
/db_xref="EnsemblGenomes-Tr:CCP45632"
/db_xref="GOA:I6YEH6"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR029045"
/db_xref="PDB:4JJT"
/db_xref="UniProtKB/TrEMBL:I6YEH6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45632.1"
/translation="MTDDILLIDTDERVRTLTLNRPQSRNALSAALRDRFFAALADAE
ADDDIDVVILTGADPVFCAGLDLKELAGQTALPDISPRWPAMTKPVIGAINGAAVTGG
LELALYCDILIASEHARFADTHARVGLLPTWGLSVRLPQKVGIGLARRMSLTGDYLSA
TDALRAGLVTEVVAHDQLLPTARRVAASIVGNNQNAVRALLASYHRIDESQTAAGLWL
EACAAKQFRTSGDTIAANREAVLQRGRAQVR"
gene complement(3138099..3139181)
/gene="ugpC"
/locus_tag="Rv2832c"
CDS complement(3138099..3139181)
/codon_start=1
/transl_table=11
/gene="ugpC"
/locus_tag="Rv2832c"
/product="Probable Sn-glycerol-3-phosphate transport
ATP-binding protein ABC transporter UgpC"
/note="Rv2832c, (MTCY16B7.10), len: 360 aa. Probable
ugpC,Sn-glycerol-3-phosphate transport ATP-binding protein
ABC transporter (see Braibant et al., 2000), similar to
others: CAC48805 probable glycerol-3-phosphate ABC
transporter ATP-binding protein from Rhizobium meliloti
(Sinorhizobium meliloti) plasmid pSymB (349 aa), FASTA
scores: opt: 1018,E(): 4.1e-53, (48.6% identity in 356 aa
overlap); Q98G42|MLL3499|UGPC SN-glycerol-3-phosphate
transport ATP-binding protein from Rhizobium loti
(Mesorhizobium loti) (366 aa), FASTA scores: opt: 1016,
E(): 5.6e-53,(48.5% identity in 367 aa overlap). But also
highly similar to many msiK proteins, ABC transporter
ATP-binding proteins possibly involved in transport of
cellolbiose and maltose (see Schlosser et al., 1997) e.g.
P96483|MSIK MSIK protein from Streptomyces reticuli (377
aa), FASTA scores: opt: 1277, E(): 1.9e-68, (58.05%
identity in 379 aa overlap); Q9L0Q1|MSIK ABC transporter
ATP-binding protein from Streptomyces coelicolor (378 aa),
FASTA scores: opt: 1276,E(): 2.1e-68, (57.65% identity in
380 aa overlap); Q54333|MSIK from Streptomyces lividans
(314 aa), FASTA scores: opt: 1217, E(): 5.9e-65, (63.7%
identity in 292 aa overlap); and other ABC-type sugar
transport proteins. Also highly similar to
O53482|Rv2038c|MTV018.25c ABC-type sugar transport protein
from Mycobacterium tuberculosis (357 aa),FASTA scores:
opt: 1248, E(): 9.4e-67, (56.8% identity in 354 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-loop), and PS00211 ABC transporters family signature.
Belongs to the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv2832c"
/db_xref="EnsemblGenomes-Tr:CCP45633"
/db_xref="GOA:I6X5H3"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR008995"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR040582"
/db_xref="UniProtKB/TrEMBL:I6X5H3"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45633.1"
/translation="MANVQYSAVTQRYPGADAPTVDNLDLDIADGEFLVLVGPSGCGK
STTLRVLAGLEPIESGRISIGDVDVTHLPPRARDVAMVFQNYALYPNMTVAANMGFAL
RNAGMSRADTRRRVLEVADMLELTDLLDRKPAKLSGGQRQRVAMGRAIVRRPRVFCMD
EPLSNLDAKLRVSTRSQISGLQRRLGTTTVYVTHDQVEAMTMGDRVAVLKDGVLQQVD
TPRALYDDPVNTFVATFIGAPAMNLIDAAVAHGVVRAPDLAIPVPDPAAERVLVGVRP
ESWDVASIGTPGSLTVHVELVEELGFESFVYATPVDQRGWSSRAPRIVFRTDRRTAVR
VGESLAIVPHSQEVRLFNSRTETRLR"
gene complement(3139174..3140484)
/gene="ugpB"
/locus_tag="Rv2833c"
CDS complement(3139174..3140484)
/codon_start=1
/transl_table=11
/gene="ugpB"
/locus_tag="Rv2833c"
/product="Probable Sn-glycerol-3-phosphate-binding
lipoprotein UgpB"
/note="Rv2833c, (MTCY16B7.09), len: 436 aa. Probable
ugpB,Sn-glycerol-3-phosphate binding lipoprotein component
of Sn-glycerol-3-phosphate transport system (see citation
below), similar to various transporters substrate-binding
periplasmic proteins e.g. Q9KDY2|BH1079
glycerol-3-phosphate ABC transporter (glycerol-3-phosphate
binding protein) from Bacillus halodurans (459 aa), FASTA
scores: opt: 357, E(): 3.1e-14, (23.4% identity in 406 aa
overlap); P72397|male putative maltose-binding protein
from Streptomyces coelicolor (423 aa), FASTA scores: opt:
318,E(): 7e-12, (23.7% identity in 430 aa overlap);
AAK78409|CAC0429 glycerol-3-phosphate ABC-transporter
periplasmic component from Clostridium acetobutylicum (447
aa), FASTA scores: opt: 305, E(): 4.5e-11, (27.15%
identity in 438 aa overlap); P10904|UGPB_ECOLI|B3453
glycerol-3-phosphate-binding periplasmic protein precursor
from Escherichia coli strain K12 (438 aa); etc. Contains
signal sequence and appropriately positioned prokaryotic
lipoprotein attachment site (PS00013)."
/db_xref="EnsemblGenomes-Gn:Rv2833c"
/db_xref="EnsemblGenomes-Tr:CCP45634"
/db_xref="GOA:P71619"
/db_xref="InterPro:IPR006059"
/db_xref="InterPro:IPR006311"
/db_xref="UniProtKB/TrEMBL:P71619"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45634.1"
/translation="MDPLNRRQFLALAAAAAGVTAGCAGMGGGGSVKSGSGPIDFWSS
HPGQSSAAERELIGRFQDRFPTLSVKLIDAGKDYDEVAQKFNAALIGTDVPDVVLLDD
RWWFHFALSGVLTALDDLFGQVGVDTTDYVDSLLADYEFNGRHYAVPYARSTPLFYYN
KAAWQQAGLPDRGPQSWSEFDEWGPELQRVVGAGRSAHGWANADLISWTFQGPNWAFG
GAYSDKWTLTLTEPATIAAGNFYRNSIHGKGYAAVANDIANEFATGILASAVASTGSL
AGITASARFDFGAAPLPTGPDAAPACPTGGAGLAIPAKLSEERKVNALKFIAFVTNPT
NTAYFSQQTGYLPVRKSAVDDASERHYLADNPRARVALDQLPHTRTQDYARVFLPGGD
RIISAGLESIGLRGADVTKTFTNIQKRLQVILDRQIMRKLAGHG"
gene complement(3140487..3141314)
/gene="ugpE"
/locus_tag="Rv2834c"
CDS complement(3140487..3141314)
/codon_start=1
/transl_table=11
/gene="ugpE"
/locus_tag="Rv2834c"
/product="Probable Sn-glycerol-3-phosphate transport
integral membrane protein ABC transporter UgpE"
/note="Rv2834c, (MTCY16B7.08), len: 275 aa. Probable
ugpE,Sn-glycerol-3-phosphate transport integral membrane
protein ABC transporter (see citation below), similar to
various permeases e.g. Q9KDY3|BH1078 glycerol-3-phosphate
ABC transporter from Bacillus halodurans (270 aa), FASTA
scores: opt: 620, E(): 4.3e-32, (34.7% identity in 268 aa
overlap); Q9X0K6|TM1122 glycerol-3-phosphate ABC
transporter permease protein from Thermotoga maritima (276
aa), FASTA scores: opt: 605, E(): 3.9e-31, (32.5% identity
in 274 aa overlap); AAG58557|UGPE SN-glycerol 3-phosphate
transport system (integral membrane protein) from
Escherichia coli strain O157:H7 and EDL933 (281 aa), FASTA
scores: opt: 574, E(): 3.7e-29, (32.95% identity in 264 aa
overlap); P10906|UGPE_ECOLI|B3451 SN-glycerol-3-phosphate
transport system permease protein from Escherichia coli
strain K12 (281 aa), FASTA scores: opt: 569, E():
7.6e-29,(32.6% identity in 264 aa overlap); etc. Contains
PS00402 Binding-protein-dependent transport systems inner
membrane comp signature."
/db_xref="EnsemblGenomes-Gn:Rv2834c"
/db_xref="EnsemblGenomes-Tr:CCP45635"
/db_xref="GOA:I6Y1U3"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:I6Y1U3"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP45635.1"
/translation="MTPDRLRSSVGYAAMLLVVTLIAGPLLFVFFTSFKDQPDIYAQP
TSWWPLRWYPQNYRTATEQIPFWTFLRNSLIITSVLAVVKFTLGVLSAFGLVFVRFPG
RTAVFLVIIAALMVPNQITVISNYALISHLGLRNTFAGIILPLAGVAFGTFLMRNHFL
SLPAEIIEAARMDGARWWQLLLRVVLPMSRPTMVAVGVITVVNEWNEYLWPFLMSDDE
SVAPLPIGLTFLQQAEGVTNWGPVMAVTLLAMLPILLVFIALQRQMIKGLTSGAVKG"
gene complement(3141311..3142222)
/gene="ugpA"
/locus_tag="Rv2835c"
CDS complement(3141311..3142222)
/codon_start=1
/transl_table=11
/gene="ugpA"
/locus_tag="Rv2835c"
/product="Probable Sn-glycerol-3-phosphate transport
integral membrane protein ABC transporter UgpA"
/note="Rv2835c, (MTCY1B7.07), len: 303 aa. Probable
ugpA,Sn-glycerol-3-phosphate transport integral membrane
protein ABC transporter (see citation below), similar to
various permeases e.g. Q9RK71|SCF11.19 probable sugar
transporter inner membrane protein from Streptomyces
coelicolor (316 aa), FASTA scores: opt: 643, E(): 3.1e-35,
(38.85% identity in 291 aa overlap); Q9KDY4|BH1077
glycerol-3-phosphate ABC transporter (permease) from
Bacillus halodurans (315 aa),FASTA scores: opt: 548, E():
6.2e-29, (31.5% identity in 295 aa overlap);
AAK78407|CAC0427 glycerol-3-phosphate ABC-transporter,
permease component from Clostridium acetobutylicum (304
aa), FASTA scores: opt: 538, E(): 2.8e-28, (29.1% identity
in 292 aa overlap); etc. Contains PS00062 Aldo/keto
reductase family signature 2, and PS00402
Binding-protein-dependent transport systems inner membrane
comp signature."
/db_xref="EnsemblGenomes-Gn:Rv2835c"
/db_xref="EnsemblGenomes-Tr:CCP45636"
/db_xref="GOA:I6XFF3"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:I6XFF3"
/inference="protein motif:PROSITE:PS00402"
/inference="protein motif:PROSITE:PS00062"
/protein_id="CCP45636.1"
/translation="MAAPQRARLRSSKERVRDYALFVVLVGPNVALLLLFVYRPLADN
IRLSFFDWNVSDPSARFVGLSNYTEWFTRSDTRQIVFNTAVFTGAAVVGSMVLGLALA
MLLDRPLRGRNLVRSTVFAPFVISGAAVGLAAQFVFDPHFGLIQDLLRRIGVGVPDFY
QDARWALFMVTITYVWKNLGYTFVIYLAALQGVRRDLLEAAEIDGASRWAVFRRVLLP
QLRPTTFFLSITVLINSLQVFDVINVMTRGGPEGTGTTTMVYQVYVETFRNFRAGYGA
TVATIMFLVLLAVTYYQVRVMDRGQRQ"
gene complement(3142309..3143628)
/gene="dinF"
/locus_tag="Rv2836c"
CDS complement(3142309..3143628)
/codon_start=1
/transl_table=11
/gene="dinF"
/locus_tag="Rv2836c"
/product="Possible DNA-damage-inducible protein F DinF"
/note="Rv2836c, (MTCY16B7.06), len: 439 aa. Possible
dinF,DNA-damage-inducible protein F, integral membrane
protein,similar to others e.g. BAB38450|ECS5027|AAG59243
from Escherichia coli strain O157:H7 (459 aa), FASTA
scores: opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa
overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli
strain K12 (459 aa), FASTA scores: opt: 491, E():
1e-20,(29.35% identity in 443 aa overlap); Q98B90|MLR5680
from Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA
scores: opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa
overlap); etc. But also similar or highly similar to other
hypothetical proteins e.g. Q9X8U6|SCH24.32c hypothetical
46.3 KDA protein from Streptomyces coelicolor (448
aa),FASTA scores: opt: 981, E(): 1.1e-48, (42.35% identity
in 437 aa overlap). Contains PS00213 Lipocalin signature."
/db_xref="EnsemblGenomes-Gn:Rv2836c"
/db_xref="EnsemblGenomes-Tr:CCP45637"
/db_xref="GOA:P71616"
/db_xref="InterPro:IPR002528"
/db_xref="UniProtKB/TrEMBL:P71616"
/inference="protein motif:PROSITE:PS00213"
/protein_id="CCP45637.1"
/translation="MSQVGHRAGGRQIAQLALPALGVLAAEPLYLLFDIAVVGRLGAI
SLAGLAIGSLVLGLVGSQATFLSYGTTARAARRYGAGNRVAAVTEGVQATWLALGLGA
LVVVVVEATATPLVSAIASGDGITAAALPWLRIAILGTPAILVSLAGNGWLRGVQDTV
RPLRYVVAGFGSSALLCPLLVYGWLGLPRWGLTGSAVANLVGQWLAALLFAGALLAER
VSLRPDRAVLGAQLMMARDLIVRTLAFQVCYVSAAAVAARFGAAALAAHQVVLQLWGL
LALVLDSLAIAAQSLVGAALGAGDAGHAKAVAWRVTAFSLLAAGILAAALGLGSSVLP
GLFTDDRSVLAAIGVPWWFMVVQLPFAGIVFAVDGVLLGAGDAAFMRTATVASALVGF
LPLVWLSLAYGWGLAGIWSGLGTFIVLRLIFVGWRAYSGRWAVTGAA"
gene complement(3143635..3144645)
/locus_tag="Rv2837c"
CDS complement(3143635..3144645)
/codon_start=1
/transl_table=11
/locus_tag="Rv2837c"
/product="Conserved protein"
/note="Rv2837c, (MTCY16B7.05), len: 336 aa. Conserved
protein, showing some similarity with other proteins e.g.
O67552|AQ_1630 hypothetical 36.2 KDA protein from Aquifex
aeolicus (325 aa), FASTA scores: opt: 498, E():
3.6e-25,(32.8% identity in 314 aa overlap); Q9X1T1|TM1595
conserved hypothetical protein from Thermotoga maritima
(333 aa),FASTA scores: opt: 482, E(): 4.1e-24, (34.85%
identity in 304 aa overlap); Q9RW43|DR0826 conserved
hypothetical protein from Deinococcus radiodurans (338
aa), FASTA scores: opt: 444, E(): 1.3e-21, (33.85%
identity in 331 aa overlap); etc. Equivalent to AAK47229
from Mycobacterium tuberculosis strain CDC1551 (316 aa)
but longer 20 aa."
/db_xref="EnsemblGenomes-Gn:Rv2837c"
/db_xref="EnsemblGenomes-Tr:CCP45638"
/db_xref="GOA:P71615"
/db_xref="InterPro:IPR001667"
/db_xref="InterPro:IPR003156"
/db_xref="InterPro:IPR038763"
/db_xref="PDB:5CET"
/db_xref="PDB:5JJU"
/db_xref="UniProtKB/Swiss-Prot:P71615"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45638.1"
/translation="MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHP
DADTIGAGLALALVLDGCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLV
VTVDIPSVDRLGALGDLTDSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILD
AWGKPIDPRVAHCIYAGLATDTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHP
FTWLPLLSRVLGSAQLVSEAVGGRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAE
VAAVFKEVEPHRWSVSMRAKTVNLAAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAA
LG"
gene complement(3144620..3145171)
/gene="rbfA"
/locus_tag="Rv2838c"
CDS complement(3144620..3145171)
/codon_start=1
/transl_table=11
/gene="rbfA"
/locus_tag="Rv2838c"
/product="Probable ribosome-binding factor a RbfA (P15B
protein)"
/note="Rv2838c, (MTCY16B7.04), len: 183 aa. Probable
rbfA,ribosome-binding factor A, equivalent to
Q9Z5I8|RBFA_MYCLE|ML1555|MLCB596.15 probable
ribosome-binding factor a from Mycobacterium leprae (164
aa), FASTA scores: opt: 739, E(): 1.8e-40, (75.6% identity
in 160 aa overlap). Also highly similar or similar to
others e.g. Q9Z527|RBFA_STRCO|SC9F2.08c from Streptomyces
coelicolor (160 aa), FASTA scores: opt: 425, E():
2.8e-20,(50.35% identity in 141 aa overlap);
P32731|RBFA_BACSU from Bacillus subtilis (117 aa), FASTA
scores: opt: 199, E(): 7.8e-06, (32.4% identity in 108 aa
overlap); P09170|RBFA_ECOLI|P15B|B3167 from Escherichia
coli strain K12 (132 aa), FASTA scores: opt: 166, E():
0.0011, (29.65% identity in 118 aa overlap); etc. Belongs
to the RBFA family. Note that appears to be longer in
C-terminus than other RbfA proteins."
/db_xref="EnsemblGenomes-Gn:Rv2838c"
/db_xref="EnsemblGenomes-Tr:CCP45639"
/db_xref="GOA:P9WHJ7"
/db_xref="InterPro:IPR000238"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR020053"
/db_xref="InterPro:IPR023799"
/db_xref="UniProtKB/Swiss-Prot:P9WHJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45639.1"
/translation="MADAARARRLAKRIAAIVASAIEYEIKDPGLAGVTITDAKVTAD
LHDATVYYTVMGRTLHDEPNCAGAAAALERAKGVLRTKVGAGTGVRFTPTLTFTLDTI
SDSVHRMDELLARARAADADLARVRVGAKPAGEADPYRDNGSVAQSPAPGGLGIRTSD
GPEAVEAPLTCGGDTGDDDRPKE"
gene complement(3145171..3147873)
/gene="infB"
/locus_tag="Rv2839c"
CDS complement(3145171..3147873)
/codon_start=1
/transl_table=11
/gene="infB"
/locus_tag="Rv2839c"
/product="Probable translation initiation factor if-2
InfB"
/note="Rv2839c, (MTCY16B7.03), len: 900 aa. Probable
infB,translation initiation factor if-2, highly similar,
but in part, to Q9Z5I9|IF2_MYCLE|ML1556|MLCB596.14
translation initiation factor if-2 from Mycobacterium
leprae (924 aa),FASTA scores: opt: 4548, E(): 2.4e-132,
(83.6% identity in 933 aa overlap). Also similar in part
to others e.g. Q9K3E2|SC5H4.30 from Streptomyces
coelicolor (835 aa),FASTA scores: opt: 2559, E(): 1.3e-71,
(59.9% identity in 833 aa overlap); P17889|IF2_BACSU|INFB
from Bacillus subtilis (716 aa), FASTA scores: opt: 1782,
E(): 6.6e-48,(46.65% identity in 686 aa overlap);
P02995|IF2_ECOLI|INFB|SSYG|B3168|Z4529|ECS4049 from
Escherichia coli strains O157:H7 and K12 (890 aa), FASTA
scores: opt: 1708, E(): 1.3e-45, (46.2% identity in 662 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Belongs to the if-2 family."
/db_xref="EnsemblGenomes-Gn:Rv2839c"
/db_xref="EnsemblGenomes-Tr:CCP45640"
/db_xref="GOA:P9WKK1"
/db_xref="InterPro:IPR000178"
/db_xref="InterPro:IPR000795"
/db_xref="InterPro:IPR005225"
/db_xref="InterPro:IPR006847"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR015760"
/db_xref="InterPro:IPR023115"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036925"
/db_xref="UniProtKB/Swiss-Prot:P9WKK1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45640.1"
/translation="MAAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPV
ARRLRESFGGSKPAPAKGTAKSPGKGPDKSLDKALDAAIDMAAGNGKATAAPAKAADS
GGAAIVSPTTPAAPEPPTAVPPSPQAPHPGMAPGARPGPVPKPGIRTPRVGNNPFSSA
QPADRPIPRPPAPRPGTARPGVPRPGASPGSMPPRPGGAVGGARPPRPGAPRPGGRPG
APGAGRSDAGGGNYRGGGVGAAPGTGFRGRPGGGGGGRPGQRGGAAGAFGRPGGAPRR
GRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFADKIDANPAALVQA
LFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLSYGEDEGGEE
DLQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVAVDLDGSQRL
ITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAV
NKIDKEGADPAKIRGQLTEYGLVPEEFGGDTMFVDISAKQGTNIEALEEAVLLTADAA
LDLRANPDMEAQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSVVAGDAYGRVRRMVDE
HGEDVEVALPSRPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSR
KRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDDEVVLRVIDRGVGGI
TETNVNLASASDAVIIGFNVRAEGKATELASREGVEIRYYSVIYQAIDEIEQALRGLL
KPIYEENQLGRAEIRALFRSSKVGLIAGCLVTSGVMRRNAKARLLRDNIVVAENLSIA
SLRREKDDVTEVRDGFECGLTLGYADIKEGDVIESYELVQKERA"
gene complement(3147959..3148258)
/locus_tag="Rv2840c"
CDS complement(3147959..3148258)
/codon_start=1
/transl_table=11
/locus_tag="Rv2840c"
/product="Conserved hypothetical protein"
/note="Rv2840c, (MTCY16B7.02), len: 99 aa. Conserved
hypothetical protein, equivalent to
Q9Z5J0|ML1557|MLCB596.13 hypothetical 11.6 KDA protein
from Mycobacterium leprae (106 aa), FASTA scores: opt:
501, E(): 2.3e-29, (501% identity in 96 aa overlap). Also
highly similar to other hypothetical proteins e.g.
Q9KYR0|SC5H4.29 from Streptomyces coelicolor (101 aa),
FASTA scores: opt: 256, E(): 1.4e-11, (50.6% identity in
81 aa overlap); Q9APM9 from Myxococcus xanthus (111 aa),
FASTA scores: opt: 174, E(): 1.3e-05, (42.25% identity in
97 aa overlap); and similar to to others e.g. N-terminus
of CAC41675|SMC02913 from Rhizobium meliloti
(Sinorhizobium meliloti) (230 aa),FASTA scores: opt: 172,
E(): 3e-05, (42.4% identity in 66 aa overlap). Predicted
to be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2840c"
/db_xref="EnsemblGenomes-Tr:CCP45641"
/db_xref="InterPro:IPR007393"
/db_xref="InterPro:IPR035931"
/db_xref="InterPro:IPR037465"
/db_xref="UniProtKB/TrEMBL:I6XFF7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45641.1"
/translation="MRTCVGCRKRGLAVELLRVVAVSTGNGNYAVIVDTATSLPGRGA
WLHPLRQCAQQAIRRRAFARALRIAGSPDTSAVVEYLESLGELEPPGNRTGSNRT"
gene complement(3148385..3149428)
/gene="nusA"
/locus_tag="Rv2841c"
CDS complement(3148385..3149428)
/codon_start=1
/transl_table=11
/gene="nusA"
/locus_tag="Rv2841c"
/product="Probable N utilization substance protein A NusA"
/note="Rv2841c, (MTCY24A1.16, MTCY16B7.01), len: 347 aa.
Probable nusA, N-utilization substance protein
A,equivalent to Q9Z5J1|NUSA|ML1558 probable transcription
termination/antitermination factor from Mycobacterium
leprae (347 aa), FASTA scores: opt: 2054, E():
5.4e-120,(91.95% identity in 347 aa overlap). Also highly
similar to others e.g. Q9KYR1|SC5H4.28 putative
transcriptional termination/antitermination factor from
Streptomyces coelicolor (340 aa), FASTA scores: opt: 1346,
E(): 4.3e-76,(63.35% identity in 341 aa overlap);
P32727|NUSA_BACSU N utilization substance protein A (371
aa), FASTA scores: opt: 847, E(): 4.1e-45, (43.95%
identity in 346 aa overlap); Q9KA74|NUSA|BH2416
transcriptional terminator from Bacillus halodurans (382
aa), FASTA scores: opt: 846,E(): 4.8e-45, (43.15% identity
in 373 aa overlap); etc. Belongs to the NUSA family."
/db_xref="EnsemblGenomes-Gn:Rv2841c"
/db_xref="EnsemblGenomes-Tr:CCP45642"
/db_xref="GOA:P9WIV3"
/db_xref="InterPro:IPR003029"
/db_xref="InterPro:IPR009019"
/db_xref="InterPro:IPR010213"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR013735"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR022967"
/db_xref="InterPro:IPR025249"
/db_xref="InterPro:IPR030842"
/db_xref="InterPro:IPR036555"
/db_xref="PDB:1K0R"
/db_xref="PDB:2ASB"
/db_xref="PDB:2ATW"
/db_xref="UniProtKB/Swiss-Prot:P9WIV3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45642.1"
/translation="MNIDMAALHAIEVDRGISVNELLETIKSALLTAYRHTQGHQTDA
RIEIDRKTGVVRVIARETDEAGNLISEWDDTPEGFGRIAATTARQVMLQRFRDAENER
TYGEFSTREGEIVAGVIQRDSRANARGLVVVRIGTETKASEGVIPAAEQVPGESYEHG
NRLRCYVVGVTRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRS
KIAVRSNVAGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDDDPARFVANALSPAK
VVSVSVIDQTARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRGDAPPPPPGQ
PEPGVSRGMAHDR"
gene complement(3149425..3149976)
/locus_tag="Rv2842c"
CDS complement(3149425..3149976)
/codon_start=1
/transl_table=11
/locus_tag="Rv2842c"
/product="Conserved protein"
/note="Rv2842c, (MTCY24A1.15), len: 183 aa. Conserved
protein, similar to Q9Z5J2|MLCB596.11 hypothetical 13.7
KDA protein from Mycobacterium leprae (122 aa), FASTA
scores: opt: 192, E(): 2.1e-12, (50.0% identity in 128 aa
overlap) (N-terminus shorter). Also similar in part to
several hypothetical proteins e.g. Q9KYR2|SC5H4.27
hypothetical 19.8 KDA protein from Streptomyces coelicolor
(177 aa),FASTA scores: opt: 288, E(): 2.1e-12, (37.15%
identity in 148 aa overlap); O66619|Y260_AQUAE|AQ_260
hypothetical protein from Aquifex aeolicus (158 aa), FASTA
scores: opt: 230, E(): 1.7e-08, (31.35% identity in 153 aa
overlap); Q9KU82|VC0641 hypothetical protein from Vibrio
cholerae (151 aa), FASTA scores: opt: 198, E(): 2.5e-06,
(30.9% identity in 152 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2842c"
/db_xref="EnsemblGenomes-Tr:CCP45643"
/db_xref="GOA:P9WH17"
/db_xref="InterPro:IPR003728"
/db_xref="InterPro:IPR028989"
/db_xref="InterPro:IPR028998"
/db_xref="InterPro:IPR035956"
/db_xref="InterPro:IPR036847"
/db_xref="UniProtKB/Swiss-Prot:P9WH17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45643.1"
/translation="MTTGLPSQRQVIELLGADFACAGYEIEDVVIDARARPPRIAVIA
DGDAPLDLDTIAALSRRASALLDGLDGANKIRGRYLLEVSSPGVERPLTSEKHFRRAR
GRKVELVLSDGSRLTGRVGEMRAGTVALVIREDRGWAVREIPLAEIVKAVVQVEFSPP
APAELELAQSSEMGLARGTEAGA"
gene 3150171..3150716
/locus_tag="Rv2843"
CDS 3150171..3150716
/codon_start=1
/transl_table=11
/locus_tag="Rv2843"
/product="Probable conserved transmembrane alanine rich
protein"
/note="Rv2843, (MTCY24A1.14c), len: 181 aa. Probable
conserved transmembrane ala-rich protein, equivalent to
Q9Z5J3|ML1560|MLCB596.10c hypothetical 17.5 KDA protein
from Mycobacterium leprae (178 aa), FASTA scores: opt:
707,E(): 1.4e-32, (70.25% identity in 168 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2843"
/db_xref="EnsemblGenomes-Tr:CCP45644"
/db_xref="GOA:I6YAE2"
/db_xref="InterPro:IPR006311"
/db_xref="UniProtKB/TrEMBL:I6YAE2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45644.1"
/translation="MLRAAPVINRLTNRPISRRGVLAGGAALAALGVVSACGESAPKA
PAVEELRSPLDQARHDGALAAAAATAIGIPPQVAAALTVVATQRTSHARALATEIARA
AGKLVSATSETSSSSPSPTDPAAPPPAVSDVIDSLRTSAGEASRLVATTSGYRAGLLA
SIAASCTASYTVALVPSGPSI"
gene 3150713..3151201
/locus_tag="Rv2844"
CDS 3150713..3151201
/codon_start=1
/transl_table=11
/locus_tag="Rv2844"
/product="Conserved alanine rich protein"
/note="Rv2844, (MTCY24A1.13c), len: 162 aa. Conserved
ala-rich protein, equivalent to Q9Z5J4|ML1561|MLCB596.09c
hypothetical 17.5 KDA protein from Mycobacterium leprae
(165 aa), FASTA scores: opt: 771, E(): 4.9e-46, (71.5%
identity in 165 aa overlap). Also similar to
Q9KYR4|SC5H4.25c hypothetical 16.8 KDA protein from
Streptomyces coelicolor (167 aa), FASTA scores: opt:
242,E(): 1.6e-09, (38.9% identity in 144 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2844"
/db_xref="EnsemblGenomes-Tr:CCP45645"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012347"
/db_xref="InterPro:IPR029447"
/db_xref="UniProtKB/TrEMBL:I6Y1V1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45645.1"
/translation="MTSSEPAHGATPKRSPSEGSADNAALCDALAVEHATIYGYGIVS
ALSPPGVNFLVADALKQHRHRRDDVIVMLSARGVTAPIAAAGYQLPMQVSSAADAARL
AVRMENDGATAWRAVVEHAETADDRVFASTALTESAVMATRWNRVLGAWPITAAFPGG
DE"
gene complement(3151202..3152950)
/gene="proS"
/locus_tag="Rv2845c"
CDS complement(3151202..3152950)
/codon_start=1
/transl_table=11
/gene="proS"
/locus_tag="Rv2845c"
/product="Probable prolyl-tRNA synthetase ProS
(proline--tRNA ligase) (PRORS) (global RNA synthesis
factor) (proline translase)"
/note="Rv2845c, (MTCY24A1.12), len: 582 aa. Probable
proS,prolyl-tRNA synthetase, highly similar to others e.g.
Q9KYR6|SYP_STRCO|pros|SC5H4.23 from Streptomyces
coelicolor (567 aa), FASTA scores: opt: 1161, E(): 9e-64,
(57.15% identity in 574 aa overlap);
P56124|SYP_HELPY|pros|HP0238 from Helicobacter pylori
(Campylobacter pylori) (577 aa),FASTA scores: opt: 1082,
E(): 6.6e-59, (37.8% identity in 553 aa overlap);
P16659|SYP_ECOLI|pros|DRPA|B0194 from Escherichia coli
strain K12 (572 aa), FASTA scores: opt: 926, E(): 2.6e-49,
(39.85% identity in 587 aa overlap); etc. Contains PS00179
Aminoacyl-transfer RNA synthetases class-II signature 1.
Belongs to class-II aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2845c"
/db_xref="EnsemblGenomes-Tr:CCP45646"
/db_xref="GOA:P9WFT9"
/db_xref="InterPro:IPR002314"
/db_xref="InterPro:IPR002316"
/db_xref="InterPro:IPR004154"
/db_xref="InterPro:IPR004500"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR007214"
/db_xref="InterPro:IPR023717"
/db_xref="InterPro:IPR033730"
/db_xref="InterPro:IPR036621"
/db_xref="InterPro:IPR036754"
/db_xref="UniProtKB/Swiss-Prot:P9WFT9"
/inference="protein motif:PROSITE:PS00179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45646.1"
/translation="MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIRPVAPGLYSW
LPLGLRVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLKDRR
GNDYLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDEARPRAGILRAREFVMK
DSYSFDIDAAGLKAAYHAHREAYQRIFDRLQVRYVIVSAVSGAMGGSASEEFLAESPS
GEDAFVRCLESGYAANVEAVVTARPDTLPIDGLPEAVVHDTGDTPTIASLVAWANEAD
LGRTVTAADTLKNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDD
DFAKHPFLVKGYIGPKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLVAGRDFT
ADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDAFTADVLGEDGKPVR
LTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPFDVHLVIANKDAQARAGATALAA
DLDRLGVEVLLDDRQASPGVKFKDAELLGMPWIVVVGRGWADGVVELRDRFSGQTREL
VAGASLATDIAAAVTG"
gene complement(3153039..3154631)
/gene="efpA"
/locus_tag="Rv2846c"
CDS complement(3153039..3154631)
/codon_start=1
/transl_table=11
/gene="efpA"
/locus_tag="Rv2846c"
/product="Possible integral membrane efflux protein EfpA"
/note="Rv2846c, (MTCY24A1.11), len: 530 aa. Possible
efpA,integral membrane efflux protein, member of major
facilitator superfamily (MFS) possibly involved in
transport of drug (see citations below), equivalent to
Q9Z5J5|ML1562|MLCB596.08 putative transmembrane efflux
protein from Mycobacterium leprae (534 aa), FASTA scores:
opt: 2881, E(): 4.1e-160, (86.55% identity in 535 aa
overlap). Also highly similar to several membrane proteins
e.g. O69986|SC4H2.31c transmembrane efflux protein (515
aa), FASTA scores: opt: 1063, E(): 2.2e-54, (39.65%
identity in 406 aa overlap); Q9FBQ5|SCD86A.02c putative
transport integral membrane protein from Streptomyces
coelicolor (503 aa), FASTA scores: opt: 918, E():
5.8e-46,(33.7% identity in 469 aa overlap);
Q9KYU0|SCE22.23c putative transmembrane efflux protein
from Streptomyces coelicolor (514 aa), FASTA scores: opt:
888, E(): 3.3e-44,(32.85% identity in 469 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2846c"
/db_xref="EnsemblGenomes-Tr:CCP45647"
/db_xref="GOA:P9WJY5"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJY5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45647.1"
/translation="MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPT
WLPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFG
GLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASP
TGLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGL
VMIYLARTALRETNKERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLV
ALAAAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDI
LGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMH
RGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLV
LAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHAYTYGLLWVAGAAIIVGGMALFI
GYTPQQVAHAQEVKEAIDAGEL"
gene complement(3154654..3155871)
/gene="cysG"
/gene_synonym="cysG2"
/locus_tag="Rv2847c"
CDS complement(3154654..3155871)
/codon_start=1
/transl_table=11
/gene="cysG"
/gene_synonym="cysG2"
/locus_tag="Rv2847c"
/product="Possible multifunctional enzyme siroheme
synthase CysG: uroporphyrin-III C-methyltransferase
(urogen III methylase) (SUMT) (uroporphyrinogen III
methylase) (UROM) + precorrin-2 oxidase + ferrochelatase"
/note="Rv2847c, (MTCY24A1.10), len: 405 aa. Possible
cysG,multifunctional enzyme, siroheme synthase containing
uroporphyrin-III c-methyltransferase, precorrin-2 oxidase
and ferrochelatase. C-terminus highly similar to many
uroporphyrin-III c-methyltransferases e.g. Q51720|COBA
uroporphyrinogen III methyltransferase from
Propionibacterium freudenreichii (257 aa), FASTA scores:
opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa
overlap); Q9HMY4|UROM|VNG2331G
S-adenosyl-L-methionine:uroporphyrinogen III
methyltransferase from Halobacterium sp. strain NRC-1 (246
aa), FASTA scores: opt: 704, E(): 3.1e-35, (49.4% identity
in 245 aa overlap); P42437|NASF_BACSU|NASBE
uroporphyrin-III C-methyltransferase from Bacillus
subtilis (483 aa), FASTA scores: opt: 610, E(): 2.4e-29,
(42.1% identity in 240 aa overlap); etc. And highly
similar over entire length to other proteins e.g.
Q9L1C9|SCL11.09c uroporphyrinogen III methyltransferase
from Streptomyces coelicolor (410 aa), FASTA scores: opt:
1481, E(): 5.6e-82,(58.45% identity in 409 aa overlap);
Q9I0M7|CYSG|PA2611 siroheme synthase from Pseudomonas
aeruginosa (465 aa),FASTA scores: opt: 609, E(): 2.7e-29,
(34.7% identity in 444 aa overlap);
P11098|CYSG_ECOLI|B3368|Z4729|ECS4219 siroheme synthase
from Escherichia coli stains O157:H7 and K12 (457 aa),
FASTA scores: opt: 543, E(): 9.1e-27, (31.3% identity in
450 aa overlap); etc. Belongs to a family that groups
SUMT, CYSG, CBIF/COBM and CBIL/COBI. Note that previously
known as cysG2."
/db_xref="EnsemblGenomes-Gn:Rv2847c"
/db_xref="EnsemblGenomes-Tr:CCP45648"
/db_xref="GOA:I6X5I7"
/db_xref="InterPro:IPR000878"
/db_xref="InterPro:IPR006366"
/db_xref="InterPro:IPR012409"
/db_xref="InterPro:IPR014776"
/db_xref="InterPro:IPR014777"
/db_xref="InterPro:IPR035996"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6X5I7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45648.1"
/translation="MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIA
PSVTPAVEAMDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRA
DIAVEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSG
GVALVGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYG
RAMAQDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTS
AIAVPAMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERI
ELFVDVLLKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGA
VVGLSGVRGLNNS"
repeat_region complement(3155874..3155927)
/note="54 bp direct repeat
4,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTAGGCTTGGC"
repeat_region complement(3155928..3155981)
/note="54 bp direct repeat
3,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT"
repeat_region complement(3155982..3156035)
/note="54 bp direct repeat
2,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT"
repeat_region complement(3156036..3156089)
/note="54 bp direct repeat
1,GGTGGCGACCCGCGGCGCCCGGTCCCCGCGCTTGCGATCGCCACTGGCCCTGAT"
gene complement(3156148..3157521)
/gene="cobB"
/locus_tag="Rv2848c"
CDS complement(3156148..3157521)
/codon_start=1
/transl_table=11
/gene="cobB"
/locus_tag="Rv2848c"
/product="Probable cobyrinic acid A,C-diamide synthase
CobB"
/note="Rv2848c, (MTCY24A1.09), len: 457 aa. Probable
cobB,cobyrinic acid A,C-diamide synthase, highly similar
to others e.g. O27509|COBB_METTH|MTH1460 from
Methanobacterium thermoautotrophicum (447 aa), FASTA
scores: opt: 980, E(): 1.3e-49, (39.65% identity in 454 aa
overlap); Q9KBM8|BH1898 from Bacillus halodurans (465 aa),
FASTA scores: opt: 928,E(): 1.4e-46, (37.0% identity in
457 aa overlap); O68108|COBB_RHOCA from Rhodobacter
capsulatus (Rhodopseudomonas capsulata) (435 aa), FASTA
scores: opt: 921, E(): 3.3e-46, (39.35% identity in 437 aa
overlap); etc. Belongs to the COBB/COBQ family, COBB
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv2848c"
/db_xref="EnsemblGenomes-Tr:CCP45649"
/db_xref="GOA:P9WP97"
/db_xref="InterPro:IPR002586"
/db_xref="InterPro:IPR004484"
/db_xref="InterPro:IPR011698"
/db_xref="InterPro:IPR017929"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:P9WP97"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45649.1"
/translation="MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDF
IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAG
GAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGS
ARHEQVLRQACDQAGVAVLGAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVV
ARHVDLAAVIACAGSQAAHPPWDPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLR
AAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVH
AECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHE
FHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHASYLHTHPAATPGAVARFVAHA
ACNTPRA"
gene complement(3157521..3158144)
/gene="cobO"
/gene_synonym="cobA"
/locus_tag="Rv2849c"
CDS complement(3157521..3158144)
/codon_start=1
/transl_table=11
/gene="cobO"
/gene_synonym="cobA"
/locus_tag="Rv2849c"
/product="Probable cob(I)alamin adenosyltransferase CobO
(corrinoid adenosyltransferase) (corrinoid adotransferase
activity)"
/note="Rv2849c, (MTCY24A1.08), len: 207 aa. Probable
cobO,cob(I)alamin adenosyltransferase, highly similar to
Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA
scores: opt: 918, E(): 1.1e-55, (64.75% identity in 207 aa
overlap); and similar to others e.g. O30785|COBO from
Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212
aa), FASTA scores: opt: 329, E(): 2.8e-15, (44.3% identity
in 185 aa overlap); P29930|COBO_PSEDE from Pseudomonas
denitrificans (213 aa), FASTA scores: opt: 280, E():
6.5e-12, (38.9% identity in 185 aa overlap);
P31570|BTUR_SALTY|COBA from Salmonella typhimurium (196
aa), FASTA scores: opt: 278, E(): 8.4e-12, (39.8% identity
in 196 aa overlap); etc. Cofactor: manganese. Note that
previously known as cobA."
/db_xref="EnsemblGenomes-Gn:Rv2849c"
/db_xref="EnsemblGenomes-Tr:CCP45650"
/db_xref="GOA:I6Y1V6"
/db_xref="InterPro:IPR003724"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:I6Y1V6"
/protein_id="CCP45650.1"
/translation="MPQGNPLAVPNDGLTTRARRNMPILAVHTGEGKGKSTAAFGMAL
RAWNAGLDIAVFQFVKSAKWKVGEEAAFRQLGRLHDQHGIGGAVEWHKMGAGWSWTRT
SRKAGTDVDRAAAAADGWAEIALRLATQRHDFYLLDEFTYPLKWGWLDVDEVVDVLRA
RPGHQHVVITGRDAPQRLVAAADLVTEMTKVKHPMDAGRKGQKGIEW"
gene complement(3158165..3160054)
/locus_tag="Rv2850c"
CDS complement(3158165..3160054)
/codon_start=1
/transl_table=11
/locus_tag="Rv2850c"
/product="Possible magnesium chelatase"
/note="Rv2850c, (MTCY24A1.07), len: 629 aa. Possible
magnesium-chelatase, highly similar (but with gaps) to
magnesium-chelatases from notably photosynthetic organisms
involved in chlorophyll biosynthesis e.g. Q9RJ18|SCI8.35c
putative chelatase from Streptomyces coelicolor (672
aa),FASTA scores: opt: 1941, E(): 2.1e-85, (54.65%
identity in 675 aa overlap); Q9HZQ5|PA2942 probable
magnesium chelatase from Pseudomonas aeruginosa (338 aa),
FASTA scores: opt: 991, E(): 2.7e-40, (49.45% identity in
368 aa overlap); O33549|BCHI mg protoporphyrin IX
chelatase subunit from Rhodobacter sphaeroides
(Rhodopseudomonas sphaeroides) (334 aa), FASTA scores:
opt: 833, E(): 9.4e-33, (50.65% identity in 318 aa
overlap); O30819|BCHI_RHOSH magnesium-chelatase 38 KDA
subunit from Rhodobacter sphaeroides (Rhodopseudomonas
sphaeroides) (334 aa), FASTA scores: opt: 828, E():
1.6e-32, (50.3% identity in 318 aa overlap); etc.
Equivalent to AAK47242 from Mycobacterium tuberculosis
strain CDC1551 (610 aa) but longer 19 aa. COULB belong to
the mg-chelatase subunits D/I family."
/db_xref="EnsemblGenomes-Gn:Rv2850c"
/db_xref="EnsemblGenomes-Tr:CCP45651"
/db_xref="GOA:P9WPR3"
/db_xref="InterPro:IPR002035"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011704"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036465"
/db_xref="InterPro:IPR041628"
/db_xref="InterPro:IPR041702"
/db_xref="UniProtKB/Swiss-Prot:P9WPR3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45651.1"
/translation="MKPYPFSAIVGHDRLRLALLLCAVRPEIGGALIRGEKGTAKSTA
VRGLAALLSVATGSTETGLVELPLGATEDRVVGSLDLQRVMRDGEHAFSPGLLARAHG
GVLYVDEVNLLHDHLVDILLDAAAMGRVHVERDGISHSHEARFVLIGTMNPEEGELRP
QLLDRFGLTVDVQASRDIDVRVQVIRRRMAYEADPDAFVARYADADAELAHRIAAARA
TVDDVVLGDNELRRIAALCAAFDVDGMRADLVVARTAAAHAAWRGVRTVEEQDIRAAA
ELALPHRRRRDPFDDHGIDRDQLDEALALASVDPEPEPDPPGGGQSANEPASQPNSRS
KSTEPGAPSSMGDDPPRPASPRLRSSPRPSAPPSKIFRTRALRVPGVGTGAPGRRSRA
RNASGSVVAAAEVSDPDAHGLHLFATLLAAGERAFGAGPLRPWPDDVRRAIREGREGN
LVIFVVDASGSMAARDRMAAVSGATLSLLRDAYQRRDKVAVITFRQHEATLLLSPTSS
AHIAGRRLARFSTGGKTPLAEGLLAARALIIREKVRDRARRPLVVVLTDGRATAGPDP
LGRSRTAAAGLVAEGAAAVVVDCETSYVRLGLAAQLARQLGAPVVRLEQLHADYLVHA
VRGVA"
gene complement(3160051..3160521)
/locus_tag="Rv2851c"
CDS complement(3160051..3160521)
/codon_start=1
/transl_table=11
/locus_tag="Rv2851c"
/product="GCN5-related N-acetyltransferase"
/note="Rv2851c, (MTCY24A1.06), len: 156 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain. See Vetting et al. 2005.
Similar to others e.g. Q9KP14|VC2565 ELAA protein from
Vibrio cholerae (149 aa), FASTA scores: opt: 360, E():
1e-18, (46.05% identity in 139 aa overlap); Q9I717|PA0115
hypothetical protein from Pseudomonas aeruginosa (150
aa),FASTA scores: opt: 341, E(): 2.4e-17, (43.65% identity
in 142 aa overlap); Q9K8M4|BH2982 hypothetical protein
from Bacillus halodurans (155 aa), FASTA scores: opt: 320,
E(): 8e-16, (40.85% identity in 142 aa overlap);
P52077|ELAA_ECOLI|B2267 protein ELAA from Escherichia coli
strain K12 (153 aa), FASTA scores: opt: 269, E():
3.8e-12,(35.7% identity in 140 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2851c"
/db_xref="EnsemblGenomes-Tr:CCP45652"
/db_xref="GOA:P9WFQ5"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/Swiss-Prot:P9WFQ5"
/protein_id="CCP45652.1"
/translation="MTEALRRVWAKDLDARALYELLKLRVEVFVVEQACPYPELDGRD
LLAETRHFWLETPDGEVTCTLRLMEEHAGGEKVFRIGRLCTKRDARGQGHSNRLLCAA
LAEVGDYPCRIDAQAYLTAMYAQHGFVRDGDEFLDDGIPHVPMLRPGSGQVERP"
repeat_region complement(3160522..3160583)
/note="62 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene complement(3160580..3162061)
/gene="mqo"
/locus_tag="Rv2852c"
CDS complement(3160580..3162061)
/codon_start=1
/transl_table=11
/gene="mqo"
/locus_tag="Rv2852c"
/product="Probable malate:quinone oxidoreductase Mqo
(malate dehydrogenase [acceptor])"
/note="Rv2852c, (MT2918, MTCY24A1.05), len: 493 aa.
Probable mqo, malate:quinone oxidoreductase, highly
similar to others e.g. O69282|MQO_CORGL from
Corynebacterium glutamicum (Brevibacterium flavum) (499
aa), FASTA scores: opt: 1701, E(): 1.2e-101, (50.7%
identity in 495 aa overlap); Q9Z9Q7|BH3960 from Bacillus
halodurans (500 aa),FASTA scores: opt: 1632, E(): 3.3e-97,
(48.55% identity in 486 aa overlap); Q9HYF4|MQOA|PA3452
from Pseudomonas aeruginosa (523 aa), FASTA scores: opt:
1604, E(): 2.1e-95,(49.1% identity in 487 aa overlap)
(N-terminus longer); P33940|MQO_ECOLI|B2210 from
Escherichia coli strain K12 (548 aa), FASTA scores: opt:
1525, E(): 2.7e-90, (48.15% identity in 492 aa overlap);
etc. Belongs to the MQO family. Cofactors: FAD."
/db_xref="EnsemblGenomes-Gn:Rv2852c"
/db_xref="EnsemblGenomes-Tr:CCP45653"
/db_xref="GOA:P9WJP5"
/db_xref="InterPro:IPR006231"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WJP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45653.1"
/translation="MSDLARTDVVLIGAGIMSATLGVLLRRLEPNWSITLIERLDAVA
AESSGPWNNAGTGHSALCEMNYTPEMPDGSIDITKAVRVNEQFQVTRQFWAYAAENGI
LTDVRSFLNPVPHVSFVHGSRGVEYLRRRQKALAGNPLFAGTEFIESPDEFARRLPFM
AAKRAFSEPVALNWAADGTDVDFGALAKQLIGYCVQNGTTALFGHEVRNLSRQSDGSW
TVTMCNRRTGEKRKLNTKFVFVGAGGDTLPVLQKSGIKEVKGFAGFPIGGRFLRAGNP
ALTASHRAKVYGFPAPGAPPLGALHLDLRFVNGKSWLVFGPYAGWSPKFLKHGQISDL
PRSIRPDNLLSVLGVGLTERRLLNYLISQLRLSEPERVSALREFAPSAIDSDWELTIA
GQRVQVIRRDERNGGVLEFGTTVIGDADGSIAGLLGGSPGASTAVAIMLDVLQKCFAN
RYQSWLPTLKEMVPSLGVQLSNEPALFDEVWSWSTKALKLGAA"
gene 3162268..3164115
/gene="PE_PGRS48"
/locus_tag="Rv2853"
CDS 3162268..3164115
/codon_start=1
/transl_table=11
/gene="PE_PGRS48"
/locus_tag="Rv2853"
/product="PE-PGRS family protein PE_PGRS48"
/note="Rv2853, (MTCY24A1.04c), len: 615 aa.
PE_PGRS48,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to many e.g.
O53884|Rv0872c|MTV043.65c from Mycobacterium tuberculosis
(606 aa), FASTA scores: opt: 1405, E(): 1.4e-97, (64.6%
identity in 619 aa overlap). Equivalent to AAK47245 from
Mycobacterium tuberculosis strain CDC1551 (663 aa) but
shorter 48 aa."
/db_xref="EnsemblGenomes-Gn:Rv2853"
/db_xref="EnsemblGenomes-Tr:CCP45654"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MX26"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45654.1"
/translation="MLYVVASPDLMTAAATNLAEIGSAISTANGAAALPTVEVVAAAA
DEVSTQIAALFGAHARSYQTLSTQAAAFHSRFVQALTTAAASYASVEAANASPLQVAL
DVINAPAQTLLGRPLIGNGADGSTPGQAGGPGGLLYGNGGNGAAGGPNQAGGAGGNAG
LIGNGGAGGAGGVGAVGGKRGTGGLLFGNGGAGGQGGLGLAGINGGSGGQGGHGGNAI
LFGQGGAGGPGGTGAMGVAGTNPTPIGTAAPGSDGVNQIGNGGNTDLTGGAGGDGNAG
STTVNGGNGGTGGAARNSSGGTGNSFGGAGGAGGDGANGGDGGAGGEALTEGGATAVS
GAGGKGGNAEASGGAGGNGGKGGFAQATTSVTGGNGGNGGNGHDSNAPGGAGGSGGVG
GDGGRGGLLAGNGGTGGAGGNGGTGGAGAPGGAGGAGGKADIANSLGDNATVTGGNGG
TGGDGGSALGTGGAGGAGGLGGHGGAGGLLIGNGGAGGAGGLGGAGGAGGAGGEGGAG
GAGGEAIPGGASTNSAGGDGGAGGTGGNGGDGGAGGAPGLGGAGGAGGWLIGQSGSTG
GGGAGGAGGAGGAGGAGGSGGAGGHGDTTSGKNGSSGTAGFDGNPGQPG"
gene 3164152..3165192
/locus_tag="Rv2854"
CDS 3164152..3165192
/codon_start=1
/transl_table=11
/locus_tag="Rv2854"
/product="Unknown protein"
/note="Rv2854, (MTCY24A1.03c), len: 346 aa. Unknown
protein, showing similarity with Q9CD03|ML2603
hypothetical protein from Mycobacterium leprae (279 aa),
FASTA scores: opt: 154, E(): 0.0083, (33.35% identity in
87 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2854"
/db_xref="EnsemblGenomes-Tr:CCP45655"
/db_xref="GOA:O05805"
/db_xref="InterPro:IPR022742"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O05805"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45655.1"
/translation="MTGWVPDVLPGYWQCTIPLGPDPDDEGDIVATLVGRGPQTGKAR
GDTTGAHHTVLAVHGYTDYFFHTELADHFANRGFAFYALDLRKCGRSRAPGQTPHFIT
DLARYDTELEHSLSIINEQNRSAKVLVYGHSAGGLIVSLWLDRLRQRGEITRAGVTGL
VLNSPFLDLQGPAILRLPLTSAFFAAMARMRPKWVARPPKEGGYGCTLHRDYDGEFDY
NLQWKPVGGFPVTFGWIHASRRGHARLHRGIDVGVPNLILCSDHTVREKADPATLHRG
DAVLDVTHITRWAGCIGNRSTVIAVADAKHDVFLSLPQPRQMAYRRLDLWLDDYLGTH
NDTDASASSGKG"
gene 3165205..3166584
/gene="mtr"
/gene_synonym="gorA"
/locus_tag="Rv2855"
CDS 3165205..3166584
/codon_start=1
/transl_table=11
/gene="mtr"
/gene_synonym="gorA"
/locus_tag="Rv2855"
/product="NADPH-dependent mycothiol reductase Mtr"
/note="Rv2855, (MTCY24A1.02c), len: 459 aa.
Mtr,NADPH-dependent mycothiol reductase, proven
enzymatically but previously described as glutathione
reductase homolog (gene name: gorA) (see citation below).
Similar to others e.g. Q9L7K8|MERA mercuric reductase from
Streptomyces sp. CHR28 (474 aa), FASTA scores: opt: 719,
E(): 9e-38, (35.2% identity in 460 aa overlap);
P30341|MERA_STRLI mercuric reductase from Streptomyces
lividans (474 aa), FASTA scores: opt: 712, E(): 2.5e-37,
(34.95% identity in 455 aa overlap); Q98ED5|MLL4296 ferric
leghemoglobin reductase-2 precursor, dihydrolipoamide
dehydrogenase from Rhizobium loti (Mesorhizobium loti)
(468 aa), FASTA scores: opt: 670,E(): 1.1e-34, (30.8%
identity in 471 aa overlap); etc. Belongs to the pyridine
nucleotide-disulphide oxidoreductases class-I. Cofactor:
FAD."
/db_xref="EnsemblGenomes-Gn:Rv2855"
/db_xref="EnsemblGenomes-Tr:CCP45656"
/db_xref="GOA:P9WHH3"
/db_xref="InterPro:IPR001100"
/db_xref="InterPro:IPR004099"
/db_xref="InterPro:IPR012999"
/db_xref="InterPro:IPR016156"
/db_xref="InterPro:IPR017817"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WHH3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45656.1"
/translation="METYDIAIIGTGSGNSILDERYASKRAAICEQGTFGGTCLNVGC
IPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALSGEDYRRCA
PNIDVYRTHTRFGPVQADGRYLLRTDAGEEFTAEQVVIAAGSRPVIPPAILASGVDYH
TSDTVMRIAELPEHIVIVGSGFIAAEFAHVFSALGVRVTLVIRGSCLLRHCDDTICER
FTRIASTKWELRTHRNVVDGQQRGSGVALRLDDGCTINADLLLVATGRVSNADLLDAE
QAGVDVEDGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDT
QSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAYGWAMEDTS
GIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAAEMARGQYWIHPALPEV
VENALLGLR"
gene 3166684..3167802
/gene="nicT"
/locus_tag="Rv2856"
CDS 3166684..3167802
/codon_start=1
/transl_table=11
/gene="nicT"
/locus_tag="Rv2856"
/product="Possible nickel-transport integral membrane
protein NicT"
/note="Rv2856, (MTCY24A1.01c), len: 372 aa. Possible
nicT,nickel-transport integral membrane protein, similar
to transport proteins and hydrogenase cluster proteins
e.g. BAB58860|SAV2698 hypothetical 37.9 KDA protein from
Staphylococcus aureus subsp. aureus Mu50 (338 aa), FASTA
scores: opt: 1082, E(): 7.1e-60, (48.05% identity in 335
aa overlap); Q97ZB2|HOXN high-affinity nickel-transport
protein from Sulfolobus solfataricus (373 aa), FASTA
scores: opt: 922, E(): 6.6e-50, (42.2% identity in 372 aa
overlap); P23516|HOXN_ALCEU high-affinity nickel transport
protein (integral membrane protein) from Alcaligenes
eutrophus (Ralstonia eutropha) (351 aa), FASTA scores:
opt: 904, E(): 8.3e-49, (41.9% identity in 339 aa
overlap); Q45247|HUPN_BRAJA hydrogenase nickel
incorporation protein from Bradyrhizobium japonicum (381
aa), FASTA scores: opt: 853, E(): 1.3e-45, (41.65%
identity in 329 aa overlap); etc. Seems to belong to the
HOXN/HUPN/NIXA family of nickel transporters (NiCoT
family)."
/db_xref="EnsemblGenomes-Gn:Rv2856"
/db_xref="EnsemblGenomes-Tr:CCP45657"
/db_xref="GOA:I6YEJ7"
/db_xref="InterPro:IPR004688"
/db_xref="InterPro:IPR011541"
/db_xref="UniProtKB/TrEMBL:I6YEJ7"
/inference="protein motif:PROSITE:PS00190"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45657.1"
/translation="MASSQLDRQRSRSAKMNRALTAAEWWRLGLMFAVIVALHLVGWL
TVTLLVEPARLSLGGKAFGIGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMSDGHRPL
AVGFFFSLGHSTVVFGLAVMLVTGLKAIVGPVENDSSTLHHYTGLIGTSISGAFLYLI
GILNVIVLVGIVRVFAHLRRGDYDEAELEQQLDNRGLLIRFLGRFTKSLTKSWHMYPV
GFLFGLGFDTATEIALLVLAGTSAAAGLPWYAILCLPVLFAAGMCLLDTIDGSFMNFA
YGWAFSSPVRKIYYNITVTGLSVAVALLIGSVELLGLIANQLGWQGPFWDWLGGLDLN
TVGFVVVAMFALTWAIALLVWHYGRVEERWTPAPDRTT"
gene complement(3168583..3169359)
/locus_tag="Rv2857c"
CDS complement(3168583..3169359)
/codon_start=1
/transl_table=11
/locus_tag="Rv2857c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv2857c, (MTV003.03c), len: 258 aa. Probable
short-chain dehydrogenase/reductase, highly similar to
various dehydrogenases e.g. O88068|SCI35.33c probable
dehydrogenase (SDR family) from Streptomyces coelicolor
(260 aa), FASTA scores: opt: 1208, E(): 2e-68, (72.35%
identity in 253 aa overlap); Q9I376|PA1649 from
Pseudomonas aeruginosa probable short-chain dehydrogenase
(253 aa),FASTA scores: opt: 569, E(): 2.1e-28, (39.2%
identity in 255 aa overlap); Q9EX74|MLHA SDR-like enzyme
from Rhodococcus erythropolis (246 aa), FASTA scores: opt:
567,E(): 2.8e-28, (41.15% identity in 248 aa overlap);
etc. Also similar to many Mycobacterium tuberculosis
dehydrogenases e.g. FABG3|Rv2002|MT2058|MTCY39.16c
putative oxidoreductase (260 aa), FASTA score: (38.3%
identity in 248 aa overlap). Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv2857c"
/db_xref="EnsemblGenomes-Tr:CCP45658"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6Y1W3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45658.1"
/translation="MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDV
EAGGAAADELSGLFVPTDVCDEDAVNGLFDGAAETYGRIDIAFNNAGISPPEDNLIEN
TELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTAS
KGGVLAMSRELGVQFARQGIRVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRF
AEPDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL"
gene complement(3169356..3170723)
/gene="aldC"
/locus_tag="Rv2858c"
CDS complement(3169356..3170723)
/codon_start=1
/transl_table=11
/gene="aldC"
/locus_tag="Rv2858c"
/product="Probable aldehyde dehydrogenase AldC"
/note="Rv2858c, (MTV003.04c), len: 455 aa. Probable
aldC,aldehyde dehydrogenase, similar to many e.g.
O88069|SCI35.34c putative aldehyde dehydrogenase from
Streptomyces coelicolor (483 aa), FASTA scores: opt:
1872,E(): 6.4e-109, (64.5% identity in 448 aa overlap);
Q9FAB1|ALDH|BT-ALDH aldehyde dehydrogenase from Bacillus
thermoleovorans (497 aa), FASTA scores: opt: 1157, E():
2.1e-64, (44.3% identity in 458 aa overlap); O33455|CYMC
P-CUMIC aldehyde dehydrogenase from Pseudomonas putida
(494 aa), FASTA scores: opt: 1149, E(): 6.5e-64, (43.15%
identity in 452 aa overlap);
P40047|DHA5_YEAST|ALD5|ALDH5|ALD3|YER073W aldehyde
dehydrogenase from Saccharomyces cerevisiae (Baker's
yeast) (519 aa), FASTA scores: opt: 1091, E(): 2.7e-60,
(38.55% identity in 459 aa overlap);
P80668|FEAB_ECOLI|PADA|MAOB|B1385 phenylacetaldehyde
dehydrogenase from Escherichia coli strain K12 (499
aa),FASTA scores: opt: 1074, E(): 3e-59, (42.2% identity
in 462 aa overlap); etc. Also similar to many M.
tuberculosis dehydrogenases e.g. P71823|Rv0768|MTCY369.13
(489 aa),FASTA score: (38.1% identity in 467 aa overlap).
Contains PS00687 Aldehyde dehydrogenases glutamic acid
active site and PS00070 Aldehyde dehydrogenases cysteine
active site. Belongs to the aldehyde dehydrogenases
family."
/db_xref="EnsemblGenomes-Gn:Rv2858c"
/db_xref="EnsemblGenomes-Tr:CCP45659"
/db_xref="GOA:O33340"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016160"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/TrEMBL:O33340"
/inference="protein motif:PROSITE:PS00070"
/inference="protein motif:PROSITE:PS00687"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45659.1"
/translation="MSTTQLINPATEEVLASVDHTDANAVDDAVQRARAAQRRWARLA
PAQRAAGLRAFAAAVQAHLDELAALEVANSGHPIVSAEWEAGHVRDVLAFYAASPERL
SGRQIPVAGGVDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTP
LTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVMAG
AAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQDCCARSRILVQRSVY
DRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVAGYVPDDAPVAFRGTAPAGR
GFWFPPTVLTPKRGDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDL
SRALRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIA
VGEEM"
gene complement(3170720..3171646)
/locus_tag="Rv2859c"
CDS complement(3170720..3171646)
/codon_start=1
/transl_table=11
/locus_tag="Rv2859c"
/product="Possible amidotransferase"
/note="Rv2859c, (MTV003.05c), len: 308 aa. Possible
amidotransferase, equivalent (but longer 58 aa) to
Q9CBU9|ML1573 possible amidotransferase from Mycobacterium
leprae (249 aa), FASTA scores: opt: 1226, E():
3e-64,(71.55% identity in 239 aa overlap). Also similar to
other amidotransferases and hypothetical proteins, but
shorter in N-terminus e.g. O88072|SCI35.37 hypothetical
25.3 KDA protein from Streptomyces coelicolor (242 aa),
FASTA scores: opt: 683, E(): 1.2e-32, (47.65% identity in
235 aa overlap); AAK79730|Q97I88|CAC1764 predicted
glutamine amidotransferase from Clostridium acetobutylicum
(241 aa),FASTA scores: opt: 458, E(): 1.6e-19, (32.95%
identity in 246 aa overlap); AAK75201|Q97QV9|SP1089
glutamine amidotransferase class I from Streptococcus
pneumoniae (229 aa), FASTA scores: opt: 431, E(): 5.6e-18,
(34.75% identity in 236 aa overlap); etc. Contains three
17 aa repeats at the N-terminus very similar to those in
other Mycobacterium tuberculosis proteins e.g.
Q10699|YY30_MYCTU|Rv2090|MT2151|MTCY49.30 putative 5'-3'
exonuclease RV2090."
/db_xref="EnsemblGenomes-Gn:Rv2859c"
/db_xref="EnsemblGenomes-Tr:CCP45660"
/db_xref="GOA:O33341"
/db_xref="InterPro:IPR011697"
/db_xref="InterPro:IPR017926"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:O33341"
/protein_id="CCP45660.1"
/translation="MDLSASRSDGGDPLRPASPRLRSPVSDGGDPLRPASPRLRSPVS
DGGDPLRPASPRLRSPLGASRPVVGLTAYLEQVRTGVWDIPAGYLPADYFEGITMAGG
VAVLLPPQPVDPESVGCVLDSLHALVITGGYDLDPAAYGQEPHPATDHPRPGRDAWEF
ALLRGALQRGMPVLGICRGTQVLNVALGGTLHQHLPDILGHSGHRAGNGVFTRLPVHT
ASGTRLAELIGESADVPCYHHQAIDQVGEGLVVSAVDVDGVIEALELPGDTFVLAVQW
HPEKSLDDLRLFKALVDAASGYAGRQSQAEPR"
repeat_region complement(3171468..3171518)
/locus_tag="Rv2859c"
/note="51 bp direct repeat
1,GTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC"
repeat_region complement(3171522..3171572)
/locus_tag="Rv2859c"
/note="51 bp direct repeat
2,GTCCGATGGTGGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC"
repeat_region complement(3171576..3171616)
/locus_tag="Rv2859c"
/note="(41 bp) part of 51 bp direct repeat
3,GGCGACCCGCTGCGCCCGGCTTCGCCGCGCTTGCGATCGCC"
gene complement(3171627..3173000)
/gene="glnA4"
/locus_tag="Rv2860c"
CDS complement(3171627..3173000)
/codon_start=1
/transl_table=11
/gene="glnA4"
/locus_tag="Rv2860c"
/product="Probable glutamine synthetase GlnA4 (glutamine
synthase) (GS-II)"
/note="Rv2860c, (MTV003.06c), len: 457 aa. Probable
glnA4,glutamine synthetase class II, similar to many
glutamine synthases e.g. O88070|SCI35.35c from
Streptomyces coelicolor (462 aa), FASTA scores: opt: 1947,
E(): 8.2e-120, (64.15% identity in 452 aa overlap);
Q98H15|MLL3074 from Rhizobium loti (Mesorhizobium loti)
(465 aa), FASTA scores: opt: 1321, E(): 7.8e-79, (46.7%
identity in 452 aa overlap); Q98EM0|MLL4187 from Rhizobium
loti (Mesorhizobium loti) (456 aa), FASTA scores: opt:
698,E(): 4.6e-38, (33.5% identity in 454 aa overlap);
Q9CDL9|GLNA from Lactococcus lactis (subsp. lactis)
(Streptococcus lactis) (446 aa), FASTA scores: opt:
633,E(): 8.2e-34, (32.45% identity in 456 aa overlap);
etc. Also similar to three other potential glutamine
synthases in Mycobacterium tuberculosis:
Q10378|GLN2_MYCTU|GLNA2|Rv2222c|MT2280|MTCY190.33c|MTCY427
.03c probable glutamine synthetase (446 aa), FASTA score:
(31.1% identity in 453 aa overlap); Rv1878|glnA3 and
Rv2220|glnA1. Belongs to the glutamine synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2860c"
/db_xref="EnsemblGenomes-Tr:CCP45661"
/db_xref="GOA:I6X5K1"
/db_xref="InterPro:IPR008146"
/db_xref="InterPro:IPR014746"
/db_xref="InterPro:IPR036651"
/db_xref="UniProtKB/TrEMBL:I6X5K1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45661.1"
/translation="MTGPGSPPLAWTELERLVAAGDVDTVIVAFTDMQGRLAGKRISG
RHFVDDIATRGVECCSYLLAVDVDLNTVPGYAMASWDTGYGDMVMTPDLSTLRLIPWL
PGTALVIADLVWADGSEVAVSPRSILRRQLDRLKARGLVADVATELEFIVFDQPYRQA
WASGYRGLTPASDYNIDYAILASSRMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEI
GFRYDEALVTCDNHAIYKNGAKEIADQHGKSLTFMAKYDEREGNSCHIHVSLRGTDGS
AVFADSNGPHGMSSMFRSFVAGQLATLREFTLCYAPTINSYKRFADSSFAPTALAWGL
DNRTCALRVVGHGQNIRVECRVPGGDVNQYLAVAALIAGGLYGIERGLQLPEPCVGNA
YQGADVERLPVTLADAAVLFEDSALVREAFGEDVVAHYLNNARVELAAFNAAVTDWER
IRGFERL"
gene complement(3173160..3174017)
/gene="mapB"
/gene_synonym="map"
/locus_tag="Rv2861c"
CDS complement(3173160..3174017)
/codon_start=1
/transl_table=11
/gene="mapB"
/gene_synonym="map"
/locus_tag="Rv2861c"
/product="Methionine aminopeptidase MapB (map) (peptidase
M)"
/note="Rv2861c, (MT2929, MTV003.07c), len: 285 aa. mapB
(alternate gene name: map), methionine
aminopeptidase,equivalent to Q9CBU7|MAPB|ML1576 methionine
aminopeptidase from Mycobacterium leprae (285 aa), FASTA
scores: opt: 1729, E(): 1e-99, (89.75% identity in 283 aa
overlap). Also highly similar to many e.g. Q9RKR2|MAP3
from Streptomyces coelicolor (285 aa), FASTA scores: opt:
1385, E(): 2e-78,(70.65% identity in 283 aa overlap);
Q9SW64|C7A10.320|AT4G37040 from Arabidopsis thaliana
(Mouse-ear cress) (305 aa), FASTA scores: opt: 914, E():
3e-49, (50.35% identity in 286 aa overlap);
P07906|AMPM_ECOLI|map|B0168|Z0178|ECS0170 from Escherichia
coli strains K12 and O157:H7 (264 aa), FASTA scores: opt:
793, E(): 8.5e-42, (51.0% identity in 245 aa overlap);
etc. Belongs to peptidase family M24A; also known as the
map family 1. Cofactor: cobalt; binds 2 ions per subunit.
Note that this gene has an N-terminal extension present in
the human map, but not in the prokaryotic map's. An
alternative start, with RBS, will give a protein
equivalent to the shorter prokaryotic map's. Conserved in
M. tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2861c"
/db_xref="EnsemblGenomes-Tr:CCP45662"
/db_xref="GOA:P9WK19"
/db_xref="InterPro:IPR000994"
/db_xref="InterPro:IPR001714"
/db_xref="InterPro:IPR002467"
/db_xref="InterPro:IPR036005"
/db_xref="PDB:1Y1N"
/db_xref="PDB:1YJ3"
/db_xref="PDB:3IU7"
/db_xref="PDB:3IU8"
/db_xref="PDB:3IU9"
/db_xref="PDB:3PKA"
/db_xref="PDB:3PKB"
/db_xref="PDB:3PKC"
/db_xref="PDB:3PKD"
/db_xref="PDB:3PKE"
/db_xref="PDB:3ROR"
/db_xref="PDB:4IDY"
/db_xref="PDB:4IEC"
/db_xref="PDB:4IF7"
/db_xref="PDB:4OOK"
/db_xref="UniProtKB/Swiss-Prot:P9WK19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45662.1"
/translation="MPSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTP
EVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPK
SCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLV
DRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVL
HYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTD
TGVEILTCL"
gene complement(3174059..3174643)
/locus_tag="Rv2862c"
CDS complement(3174059..3174643)
/codon_start=1
/transl_table=11
/locus_tag="Rv2862c"
/product="Conserved hypothetical protein"
/note="Rv2862c, (MTV003.08), len: 194 aa. Conserved
hypothetical protein, showing some similarity with others
e.g. Q9X8X5|SCH35.31c hypothetical 19.6 KDA protein from
Streptomyces coelicolor (180 aa), FASTA scores: opt:
266,E(): 2.2e-11, (34.65% identity in 179 aa overlap);
Q9Z5H1|ML0169|MLCB373.19 hypothetical 22.1 KDA protein
from Mycobacterium leprae (200 aa), FASTA scores: opt:
195, E(): 2.3e-06, (30.15% identity in 189 aa overlap);
etc. Also some similarity to
P71544|Y966_MYCTU|Rv0966c|MT0994|MTCY10D7.08 conserved
hypothetical protein from Mycobacterium tuberculosis (230
aa), FASTA scores: opt: 209, E(): 2.6e-07, (31.5% identity
in 184 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2862c"
/db_xref="EnsemblGenomes-Tr:CCP45663"
/db_xref="InterPro:IPR012551"
/db_xref="UniProtKB/TrEMBL:I6Y1W7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45663.1"
/translation="MTETGGDMVALRVSDADRNGTMRRLHNAVALGLINIDEFEQRSS
RVSFACTRSELDGLVGDLPRPGAIVTSAADRVELRGWAGSLKRHGEWIVPTRLALVRR
LGSIELDLVKARFAGPVVVIELDMMFGSLEVRLPNGASASIDDVEVYVGSASDRRKDA
PAEGTPHVVLTGRMVCGSVVIKGPRRALLRRHRG"
gene 3174747..3174995
/gene="vapB23"
/locus_tag="Rv2862A"
CDS 3174747..3174995
/codon_start=1
/transl_table=11
/gene="vapB23"
/locus_tag="Rv2862A"
/product="Possible antitoxin VapB23"
/note="Rv2862A, len: 82 aa. Possible vapB23,
antitoxin,part of toxin-antitoxin (TA) operon with Rv2863
(See Pandey and Gerdes, 2005)."
/db_xref="EnsemblGenomes-Gn:Rv2862A"
/db_xref="EnsemblGenomes-Tr:CCP45664"
/db_xref="UniProtKB/Swiss-Prot:P0CW32"
/protein_id="CCP45664.1"
/translation="MLSDEEREAFRQQAAAQQMSLSNWLRQAGLRQLEAQRQRPLRTA
QELREFFASRPDETGAEPDWQAHLQVMAESRRRGLPAP"
gene 3174992..3175372
/gene="vapC23"
/locus_tag="Rv2863"
CDS 3174992..3175372
/codon_start=1
/transl_table=11
/gene="vapC23"
/locus_tag="Rv2863"
/product="Possible toxin VapC23"
/note="Rv2863, (MTV003.09), len: 126 aa. Possible
vapC23,toxin, part of toxin-antitoxin (TA) operon with
Rv2862A,contains PIN domain (See Arcus et al., 2005;
Pandey and Gerdes, 2005). Similar to others in
Mycobacterium tuberculosis e.g.
Q50595|YI38_MYCTU|Rv1838c|MT1886|MTCY1A11.05|MTCY359.35
conserved hypothetical protein (131 aa), FASTA scores:
opt: 299, E(): 6.5e-15, (39.0% identity in 123 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2863"
/db_xref="EnsemblGenomes-Tr:CCP45665"
/db_xref="GOA:P9WF89"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF89"
/protein_id="CCP45665.1"
/translation="MIFVDTNVFMYAVGRDHPLRMPAREFLEHSLEHQDRLVTSAEAM
QELLNAYVPVGRNSTLDSALTLVRALTEIWPVEAADVAHARTLHHRHPGLGARDLLHL
ACCQRRGVTRIKTFDHTLASAFRS"
gene complement(3175454..3177265)
/locus_tag="Rv2864c"
CDS complement(3175454..3177265)
/codon_start=1
/transl_table=11
/locus_tag="Rv2864c"
/product="Possible penicillin-binding lipoprotein"
/note="Rv2864c, (MTV003.10c), len: 603 aa. Possible
penicillin-binding lipoprotein, probably located in
periplasm, equivalent to Q9CBU6|ML1577 probable penicillin
binding protein from Mycobacterium leprae (608 aa), FASTA
scores: opt: 3352, E(): 2.1e-193, (81.5% identity in 606
aa overlap). Also shows some similarity to others e.g.
P72405|PCBR from Streptomyces clavuligerus (551 aa), FASTA
scores: opt: 543, E(): 6.1e-25, (28.4% identity in 567 aa
overlap); Q9F2L0|SCH63.18c from Streptomyces coelicolor
(546 aa), FASTA scores: opt: 519, E(): 1.7e-23, (29.3%
identity in 577 aa overlap); Q9RKD1|SCE87.07 from
Streptomyces coelicolor (541 aa), FASTA scores: opt:
472,E(): 1.1e-20, (34.3% identity in 318 aa overlap); etc.
Equivalent to AAK47258 from Mycobacterium tuberculosis
strain CDC1551 (618 aa) but shorter 15 aa. Contains signal
sequence and appropriately positioned PS00013 Prokaryotic
membrane lipoprotein lipid attachment site, and PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2864c"
/db_xref="EnsemblGenomes-Tr:CCP45666"
/db_xref="GOA:O33346"
/db_xref="InterPro:IPR001460"
/db_xref="InterPro:IPR007887"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:O33346"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP45666.1"
/translation="MVTKTTLASATSGLLLLAVVAMSGCTPRPQGPGPAAEKFFAALA
IGDTASAAQLSDNPNEAREALNAAWAGLQAAHLDAQVLSAKYAEDTGTVAYRFSWHLP
KDRIWTYDGQLKMARDEGRWHVRWTTSGLHPKLGEHQTFALRADPPRRASVNEVGGTD
VLVPGYLYHYSLDAGQAGRELFGTAHAVVGALHPFDDTLNDPQLLAEQASSSTQPLDL
VTLHADDSNRVAAAIGQLPGVVITPQAELLPTDKHFAPAVLNDVKKAVVDELDGKAGW
RVVSVNQNGVDVSVLHEVAPSPASSVSITLDRVVQNAAQHAVNTRGGKAMIVVIKPST
GEILAIAQNAGADADGPVATTGLYPPGSTFKMITAGAAVERDLATPETLLGCPGEIDI
GHRTIPNYGGFDLGVVPMSRAFASSCNTTFAELSSRLPPRGLTQAARRYGIGLDYQVD
GITTVTGSVPPTVDLAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIAGRPT
AVEGDATPISQKMIDALRPMMRLVVTNGTAKEIAGCGEVFGKTGEAEFPGGSHSWFAG
YRGDLAFASLIVGGGSSEYAVRMTKVMFESLPPGYLA"
gene 3177537..3177818
/gene="relF"
/gene_synonym="relB2"
/locus_tag="Rv2865"
CDS 3177537..3177818
/codon_start=1
/transl_table=11
/gene="relF"
/gene_synonym="relB2"
/locus_tag="Rv2865"
/product="Antitoxin RelF"
/note="Rv2865, (MTV003.11), len: 93 aa. RelF,
antitoxin,part of toxin-antitoxin (TA) operon with Rv2866
(See Pandey and Gerdes, 2005), showing weak similarity
with P58235|YR54_SYNY3|SSR2754 hypothetical 9.7 KDA
protein from Synechocystis sp. strain PCC 6803 (87 aa),
FASTA scores: opt: 134, E(): 0.007, (30.65% identity in 75
aa overlap); BAB58570|SAV2408 conserved hypothetical
protein from Staphylococcus aureus subsp. aureus Mu50 (83
aa), FASTA scores: opt: 124, E(): 0.037, (27.5% identity
in 80 aa overlap). Also similar to Rv1247|MTV006.19c
hypothetical 9.8 KDA protein from Mycobacterium
tuberculosis (89 aa),FASTA scores: opt: 249, E(): 2.6e-11,
(44.2% identity in 86 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2865"
/db_xref="EnsemblGenomes-Tr:CCP45667"
/db_xref="GOA:O33347"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="PDB:3G5O"
/db_xref="UniProtKB/Swiss-Prot:O33347"
/protein_id="CCP45667.1"
/translation="MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADE
WESLQETLYWLAQPGIRESIAEADADIASGRTYGEDEIRAEFGVPRRPH"
gene 3177822..3178085
/gene="relG"
/gene_synonym="relE2"
/locus_tag="Rv2866"
CDS 3177822..3178085
/codon_start=1
/transl_table=11
/gene="relG"
/gene_synonym="relE2"
/locus_tag="Rv2866"
/product="Toxin RelG"
/note="Rv2866, (MTV003.12), len: 87 aa. RelG, toxin, part
of toxin-antitoxin (TA) operon with Rv2865 (See Pandey and
Gerdes, 2005), similar to O50461|Rv1246c|MTV006.18c
conserved hypothetical protein from Mycobacterium
tuberculosis (97 aa), FASTA scores: opt: 290, E():
3.6e-16,(54.1% identity in 85 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2866"
/db_xref="EnsemblGenomes-Tr:CCP45668"
/db_xref="GOA:O33348"
/db_xref="InterPro:IPR007712"
/db_xref="InterPro:IPR035093"
/db_xref="PDB:3G5O"
/db_xref="UniProtKB/Swiss-Prot:O33348"
/protein_id="CCP45668.1"
/translation="MPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKP
LRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDHRADIYRR"
gene complement(3178458..3179312)
/locus_tag="Rv2867c"
CDS complement(3178458..3179312)
/codon_start=1
/transl_table=11
/locus_tag="Rv2867c"
/product="GCN5-related N-acetyltransferase"
/note="Rv2867c, (MTV003.13c), len: 284 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain in C-terminal part. See
Vetting et al. 2005. Similar to others e.g.
Q9KYR8|SC5H4.21 hypothetical 31.3 KDA protein from
Streptomyces coelicolor (287 aa), FASTA scores: opt: 798,
E(): 2.4e-45, (47.95% identity in 269 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2867c"
/db_xref="EnsemblGenomes-Tr:CCP45669"
/db_xref="GOA:I6XFI7"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR013653"
/db_xref="InterPro:IPR016181"
/db_xref="InterPro:IPR016794"
/db_xref="InterPro:IPR025289"
/db_xref="UniProtKB/TrEMBL:I6XFI7"
/protein_id="CCP45669.1"
/translation="MSAPPISRLVGERQVSVVRDAAAVWRVLDDDPIESCMVAARVAD
HGIDPNAIGGELWTRRGAHESLCFAGANLIPLRGGPIDLNAFADVAMSTPRRCSSLVG
RADLVLPMWQRLEPVWGPARDVRDNQPLMALATHPSCAIDTGVRQVRPEELDSYLVAA
VDMFIGEVGVDPRLGDGGRGYRRRVAGLIAAGRAWARFEHGQVIFKAEVGSQSPAVGQ
IQGVWVHPEWRGIGLGTAGTATLAAVIVGSGRIASLYVNSFNTVARAAYARVGFKEIG
TFATVLLD"
gene complement(3179368..3180531)
/gene="gcpE"
/locus_tag="Rv2868c"
CDS complement(3179368..3180531)
/codon_start=1
/transl_table=11
/gene="gcpE"
/locus_tag="Rv2868c"
/product="Probable GcpE protein"
/note="Rv2868c, (MTV003.14c), len: 387 aa. Probable gcpE
protein (protein e), equivalent to Q9CBU5|GCPE|ML1581
hypothetical protein GCPE from Mycobacterium leprae (392
aa), FASTA scores: opt: 2247, E(): 6.8e-134, (87.65%
identity in 388 aa overlap). Highly similar to essential
gene of unknown function from Escherichia coli and other
prokaryotes e.g. Q9X7W2|GCPE_STRCO|SC6A5.16 GCPE protein
homolog from Streptomyces coelicolor (384 aa), FASTA
scores: opt: 1965, E(): 3.8e-116, (78.2% identity in 385
aa overlap); P54482|GCPE_BACSU GCPE protein homolog from
Bacillus subtilis (377 aa), FASTA scores: opt: 1157, E():
2.6e-65, (49.55% identity in 351 aa overlap);
P27433|GCPE_ECOLI|B2515|Z3778|ECS3377 GCPE protein
(protein E) from Escherichia coli strains K12 and O157:H7
(372 aa),FASTA scores: opt: 984, E(): 2e-54, (44.15%
identity in 360 aa overlap); etc. Belongs to the GCPE
family."
/db_xref="EnsemblGenomes-Gn:Rv2868c"
/db_xref="EnsemblGenomes-Tr:CCP45670"
/db_xref="GOA:P9WKG3"
/db_xref="InterPro:IPR004588"
/db_xref="InterPro:IPR011005"
/db_xref="InterPro:IPR016425"
/db_xref="UniProtKB/Swiss-Prot:P9WKG3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45670.1"
/translation="MTVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCT
TKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPVVADIHFQPRY
IFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMEKYG
KATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVAAYELLAARCDYPLHLGVT
EAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLE
IVSCPSCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGN
GKGQIFVRGEVIKTVPEAQIVETLIEEAMRLAAEMGEQDPGATPSGSPIVTVS"
gene complement(3180548..3181762)
/gene="rip"
/locus_tag="Rv2869c"
CDS complement(3180548..3181762)
/codon_start=1
/transl_table=11
/gene="rip"
/locus_tag="Rv2869c"
/product="Membrane bound metalloprotease"
/note="Rv2869c, (MTV003.15c), len: 404 aa.
Rip,metalloprotease, regulates intramembrane proteolysis
and controls membrane composition (rip, see Makinoshima
and Glickman, 2005). Similar to site two protease (S2P) in
higher eukaryotes. Conserved transmembrane
protein,equivalent to Q9CBU4|ML1582 probable integral
membrane protein from Mycobacterium leprae (404 aa), FASTA
scores: opt: 2250, E(): 1.1e-128, (82.2% identity in 404
aa overlap). Also weakly similar to other membrane
proteins or hypothetical proteins e.g. Q9A710|CC1916
putative membrane-associated zinc metalloprotease from
Caulobacter crescentus (398 aa), FASTA scores: opt: 368,
E(): 7.8e-15,(28.1% identity in 427 aa overlap). Conserved
in M. tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007). Cleaves PbpB|Rv2163c in a Zn2+
-dependent manner (See Mukherjee et al., 2009). Cleaves
proteins RskA|Rv0444c, RslA|Rv0736, and Rv3912, in M.
tuberculosis Erdman (See Sklar et al., 2010)."
/db_xref="EnsemblGenomes-Gn:Rv2869c"
/db_xref="EnsemblGenomes-Tr:CCP45671"
/db_xref="GOA:P9WHS3"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR008915"
/db_xref="InterPro:IPR036034"
/db_xref="InterPro:IPR041489"
/db_xref="UniProtKB/Swiss-Prot:P9WHS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45671.1"
/translation="MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFG
PTLWSTRRGETEYGVKAVPLGGFCDIAGMTPVEELDPDERDRAMYKQATWKRVAVLFA
GPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAA
LAGIRSGDVVVKVGDTPVSSFDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRW
IPNGQGGELQPATVGAIGVGAARVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPT
KVGALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFFLAQLNLILAAINLL
PLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATYVVLVLVVGYMLLTV
TADLVNPIRLFQ"
gene complement(3181770..3183011)
/gene="dxr"
/gene_synonym="ispC"
/locus_tag="Rv2870c"
CDS complement(3181770..3183011)
/codon_start=1
/transl_table=11
/gene="dxr"
/gene_synonym="ispC"
/locus_tag="Rv2870c"
/product="Probable 1-deoxy-D-xylulose 5-phosphate
reductoisomerase Dxr (DXP reductoisomerase)
(1-deoxyxylulose-5-phosphate reductoisomerase)"
/note="Rv2870c, (MTCY274.01c, MTV003.16c), len: 413 aa.
Probable dxr, 1-deoxy-D-xylulose 5-phosphate
reductoisomerase, equivalent to Q9CBU3|DXR|ML1583
1-deoxy-D-xylulose 5-phosphate reductoisomerase from
Mycobacterium leprae (406 aa), FASTA scores: opt:
2145,E(): 1e-124, (84.05% identity in 395 aa overlap).
Also highly similar to others e.g. Q9AJD7|DXR from
Kitasatospora griseola (Streptomyces griseolosporeus) (386
aa), FASTA scores: opt: 1176, E(): 5.2e-65, (56.45%
identity in 388 aa overlap); Q9KYS1|DXR_STRCO|SC5H4.18
from Streptomyces coelicolor (401 aa), FASTA scores: opt:
1079, E(): 5.1e-59,(52.25% identity in 396 aa overlap);
P45568|DXR|B0173 from Escherichia coli strain K12 (398
aa), FASTA scores: opt: 120, E(): 0.032, (52.9% identity
in 34 aa overlap); etc. Contains PS00133 Zinc
carboxypeptidases, zinc-binding region 2 signature.
Belongs to the DXR family. N-terminus shortened since
first submission."
/db_xref="EnsemblGenomes-Gn:Rv2870c"
/db_xref="EnsemblGenomes-Tr:CCP45672"
/db_xref="GOA:P9WNS1"
/db_xref="InterPro:IPR003821"
/db_xref="InterPro:IPR013512"
/db_xref="InterPro:IPR013644"
/db_xref="InterPro:IPR026877"
/db_xref="InterPro:IPR036169"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:2C82"
/db_xref="PDB:2JCV"
/db_xref="PDB:2JCX"
/db_xref="PDB:2JCY"
/db_xref="PDB:2JD0"
/db_xref="PDB:2JD1"
/db_xref="PDB:2JD2"
/db_xref="PDB:2Y1C"
/db_xref="PDB:2Y1D"
/db_xref="PDB:2Y1E"
/db_xref="PDB:2Y1F"
/db_xref="PDB:2Y1G"
/db_xref="PDB:3RAS"
/db_xref="PDB:3ZHX"
/db_xref="PDB:3ZHY"
/db_xref="PDB:3ZHZ"
/db_xref="PDB:3ZI0"
/db_xref="PDB:4A03"
/db_xref="PDB:4AIC"
/db_xref="PDB:4OOE"
/db_xref="PDB:4OOF"
/db_xref="PDB:4RCV"
/db_xref="UniProtKB/Swiss-Prot:P9WNS1"
/inference="protein motif:PROSITE:PS00133"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45672.1"
/translation="MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGL
AAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLN
ALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVN
KGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALG
WPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAA
AAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASV
AIASTAKPGAAGRHASTLERS"
repeat_region 3181794..3181836
/note="(43 bp) part of 51 bp direct
repeat,GTGTCGACCCGCTGCGCCCGGCTTCGCCGTGCTTGCGATCGCC. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
gene 3183138..3183395
/gene="vapB43"
/locus_tag="Rv2871"
CDS 3183138..3183395
/codon_start=1
/transl_table=11
/gene="vapB43"
/locus_tag="Rv2871"
/product="Possible antitoxin VapB43"
/note="Rv2871, (MTCY274.02), len: 85 aa. Possible
vapB43,antitoxin, part of toxin-antitoxin (TA) operon with
Rv2872,see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g.
O50456|Rv1241|MTV006.13 (86 aa), FASTA scores: opt:
172,E(): 2.9e-05, (37.2% identity in 86 aa overlap);
O53811|Rv0748|MTV041.22 (85 aa), FASTA scores: opt:
170,E(): 4e-05, (35.3% identity in 85 aa overlap); etc.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2871"
/db_xref="EnsemblGenomes-Tr:CCP45673"
/db_xref="GOA:P9WL41"
/db_xref="InterPro:IPR002145"
/db_xref="InterPro:IPR010985"
/db_xref="UniProtKB/Swiss-Prot:P9WL41"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45673.1"
/translation="MRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQ
AAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVSVDAVR"
gene 3183382..3183825
/gene="vapC43"
/locus_tag="Rv2872"
CDS 3183382..3183825
/codon_start=1
/transl_table=11
/gene="vapC43"
/locus_tag="Rv2872"
/product="Possible toxin VapC43. Contains PIN domain."
/note="Rv2872, (MTCY274.03), len: 147 aa. Possible
vapC43,toxin, part of toxin-antitoxin (TA) operon with
Rv2871,contains PIN domain, see Arcus et al. 2005. Similar
to others in Mycobacterium tuberculosis strains H37Rv and
CDC1551 e.g. O53683|Rv0277c|MTV035.05c (142 aa), FASTA
scores: opt: 357, E(): 1.4e-17, (41.45% identity in 140 aa
overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores:
opt: 350, E(): 4.3e-17, (41.55% identity in 142 aa
overlap); etc. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2872"
/db_xref="EnsemblGenomes-Tr:CCP45674"
/db_xref="GOA:P9WF55"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF55"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45674.1"
/translation="MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVL
AGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAMRLRPGERHWMAFRQLASDVDAN
GNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL"
gene 3183905..3184567
/gene="mpt83"
/gene_synonym="mpb83"
/locus_tag="Rv2873"
CDS 3183905..3184567
/codon_start=1
/transl_table=11
/gene="mpt83"
/gene_synonym="mpb83"
/locus_tag="Rv2873"
/product="Cell surface lipoprotein Mpt83 (lipoprotein
P23)"
/note="Rv2873, (MTCY274.04), len: 220 aa. Mpt83 (alternate
gene name: mpb83), cell surface lipoprotein (see citations
below). Also similar to upstream ORF
Q50769|MP70_MYCTU|MPT70|MPB70|Rv2875|MT2943|MTCY274.06
which is also known as major secreted immunogenic protein
MPT70 precursor from Mycobacterium tuberculosis (193
aa),FASTA scores: opt: 806, E(): 2.7e-38, (70.25% identity
in 185 aa overlap). Belongs to the MPT70 / MPT83 family.
Attached to the membrane by a lipid anchor."
/db_xref="EnsemblGenomes-Gn:Rv2873"
/db_xref="EnsemblGenomes-Tr:CCP45675"
/db_xref="GOA:P9WNF3"
/db_xref="InterPro:IPR000782"
/db_xref="InterPro:IPR036378"
/db_xref="UniProtKB/Swiss-Prot:P9WNF3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45675.1"
/translation="MINVQAKPAAAASLAAIAIAFLAGCSSTKPVSQDTSPKPATSPA
APVTTAAMADPAADLIGRGCAQYAAQNPTGPGSVAGMAQDPVATAASNNPMLSTLTSA
LSGKLNPDVNLVDTLNGGEYTVFAPTNAAFDKLPAATIDQLKTDAKLLSSILTYHVIA
GQASPSRIDGTHQTLQGADLTVIGARDDLMVNNAGLVCGGVHTANATVYMIDTVLMPP
AQ"
gene 3184847..3186934
/gene="dipZ"
/locus_tag="Rv2874"
CDS 3184847..3186934
/codon_start=1
/transl_table=11
/gene="dipZ"
/locus_tag="Rv2874"
/product="Possible integral membrane C-type cytochrome
biogenesis protein DipZ"
/note="Rv2874, (MT2942, MTCY274.05), len: 695 aa. Possible
dipZ, cytochrome c-type biogenesis protein (see citation
below), probable integral membrane protein, similar in
part to others or hypothetical proteins e.g.
CAC48606|SMB20213 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) (627 aa),
FASTA scores: opt: 844,E(): 7.3e-43, (32.65% identity in
643 aa overlap); Q9ZMH0|CCDA or JHP0250 putative
cytochrome C-type biogenesis protein from Helicobacter
pylori J99 (Campylobacter pylori J99) (239 aa), FASTA
scores: opt: 250, E(): 1.4e-07, (27.3% identity in 227 aa
overlap); Q9LA04|CCDA C-type cytochrome biogenesis protein
from Rhodobacter capsulatus (Rhodopseudomonas capsulata)
(252 aa), FASTA scores: opt: 245, E(): 2.9e-07, (27.85%
identity in 244 aa overlap); etc. Also similar to
O06393|CCSA|Rv0527|MTCY25D10.06 cytochrome C-type
biogenesis protein from Mycobacterium tuberculosis (259
aa), FASTA scores: opt: 280, E(): 2.4e-09, (29.3% identity
in 239 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2874"
/db_xref="EnsemblGenomes-Tr:CCP45676"
/db_xref="GOA:P9WG63"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR003834"
/db_xref="InterPro:IPR008979"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR036249"
/db_xref="InterPro:IPR041017"
/db_xref="PDB:2HYX"
/db_xref="PDB:5CYY"
/db_xref="UniProtKB/Swiss-Prot:P9WG63"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45676.1"
/translation="MVESRRAAAAASAYASRCGIAPATSQRSLATPPTISVPSGEGRC
RCHVARGAGRDPRRRLRRRRWCGRCGYHSHLTGGEFDVNRLCQQRSRERSCQLVAVPA
DPRPKRQRITDVLTLALVGFLGGLITGISPCILPVLPVIFFSGAQSVDAAQVAKPEGA
VAVRRKRALSATLRPYRVIGGLVLSFGMVTLLGSALLSVLHLPQDAIRWAALVALVAI
GAGLIFPRFEQLLEKPFSRIPQKQIVTRSNGFGLGLALGVLYVPCAGPILAAIVVAGA
TATIGLGTVVLTATFALGAALPLLFFALAGQRIAERVGAFRRRQREIRIATGSVTILL
AVALVFDLPAALQRAIPDYTASLQQQISTGTEIREQLNLGGIVNAQNAQLSNCSDGAA
QLESCGTAPDLKGITGWLNTPGNKPIDLKSLRGKVVLIDFWAYSCINCQRAIPHVVGW
YQAYKDSGLAVIGVHTPEYAFEKVPGNVAKGAANLGISYPIALDNNYATWTNYRNRYW
PAEYLIDATGTVRHIKFGEGDYNVTETLVRQLLNDAKPGVKLPQPSSTTTPDLTPRAA
LTPETYFGVGKVVNYGGGGAYDEGSAVFDYPPSLAANSFALRGRWALDYQGATSDGND
AAIKLNYHAKDVYIVVGGTGTLTVVRDGKPATLPISGPPTTHQVVAGYRLASETLEVR
PSKGLQVFSFTYG"
gene 3187030..3187611
/gene="mpt70"
/gene_synonym="mpb70"
/locus_tag="Rv2875"
CDS 3187030..3187611
/codon_start=1
/transl_table=11
/gene="mpt70"
/gene_synonym="mpb70"
/locus_tag="Rv2875"
/product="Major secreted immunogenic protein Mpt70"
/note="Rv2875, (MTCY274.06), len: 193 aa. Mpt70 (alternate
gene name: mpb70), major secreted immunogenic protein
MPT70 precursor (see citations below). Also similar to
downstream ORF Q10790|MP83_MYCTU|MPT83|MPB83|Rv2873|MT2940
|MTCY274.04 cell surface lipoprotein MPT83 precursor
(lipoprotein P23) (220 aa), FASTA scores: opt: 806, E():
1.2e-40, (70.25% identity in 185 aa overlap). Belongs to
the MPT70 / MPT83 family. Generally found as a monomer;
homodimer in culture fluids."
/db_xref="EnsemblGenomes-Gn:Rv2875"
/db_xref="EnsemblGenomes-Tr:CCP45677"
/db_xref="GOA:P9WNF5"
/db_xref="InterPro:IPR000782"
/db_xref="InterPro:IPR036378"
/db_xref="PDB:1NYO"
/db_xref="UniProtKB/Swiss-Prot:P9WNF5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45677.1"
/translation="MKVKNTIAATSFAAAGLAALAVAVSPPAAAGDLVGPGCAEYAAA
NPTGPASVQGMSQDPVAVAASNNPELTTLTAALSGQLNPQVNLVDTLNSGQYTVFAPT
NAAFSKLPASTIDELKTNSSLLTSILTYHVVAGQTSPANVVGTRQTLQGASVTVTGQG
NSLKVGNADVVCGGVSTANATVYMIDSVLMPPA"
gene 3187663..3187977
/locus_tag="Rv2876"
CDS 3187663..3187977
/codon_start=1
/transl_table=11
/locus_tag="Rv2876"
/product="Possible conserved transmembrane protein"
/note="Rv2876, (MTCY274.07), len: 104 aa. Possible
conserved transmembrane protein, equivalent (but longer 16
aa) to Q9CBU2|ML1584 possible conserved membrane protein
from Mycobacterium leprae (84 aa), FASTA scores: opt:
444,E(): 8.3e-26, (73.85% identity in 88 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2876"
/db_xref="EnsemblGenomes-Tr:CCP45678"
/db_xref="GOA:P9WL39"
/db_xref="InterPro:IPR024341"
/db_xref="UniProtKB/Swiss-Prot:P9WL39"
/protein_id="CCP45678.1"
/translation="MFGQWEFDVSPTGGIAVASTEVEHFAGSQHEVDTAEVPSAAWGW
SRIDHRTWHIVGLCIFGFLLAMLRGNHVGHVEDWFLITFAAVVLFVLARDLWGRRRGW
IR"
gene complement(3188008..3188871)
/gene_synonym="merT"
/locus_tag="Rv2877c"
CDS complement(3188008..3188871)
/codon_start=1
/transl_table=11
/gene_synonym="merT"
/locus_tag="Rv2877c"
/product="Probable conserved integral membrane protein"
/note="Rv2877c, (MTCY274.08c), len: 287 aa. Probable
conserved integral membrane protein, Mer family possibly
involved in transport of mercury, similar to others, and
to the fourth protein of the mercury resistance operon of
Streptomyces sp (or other organisms), and to putative
cytochrome-c biogenesis proteins e.g. Q9XBD1|CZA382.20C
putative integral membrane transporter from Amycolatopsis
orientalis (298 aa), FASTA scores: opt: 913, E():
7.6e-46,(51.55% identity in 293 aa overlap);
P30344|MER4_STRLI mercury resistance probable HG transport
protein from Streptomyces lividans (319 aa), FASTA scores:
opt: 427,E(): 1.2e-17, (32.85% identity in 289 aa
overlap); Q9M5P3 putative cytochrome C biogenesis protein
precursor from Arabidopsis thaliana (Mouse-ear cress) (354
aa), FASTA scores: opt: 229, E(): 4e-06, (29.85% identity
in 221 aa overlap); etc. Contains PS00044 Bacterial
regulatory proteins, lysR family signature. Note that
previously known as merT."
/db_xref="EnsemblGenomes-Gn:Rv2877c"
/db_xref="EnsemblGenomes-Tr:CCP45679"
/db_xref="GOA:I6YEL8"
/db_xref="InterPro:IPR003834"
/db_xref="UniProtKB/TrEMBL:I6YEL8"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45679.1"
/translation="MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDSAGRTG
PLSAVGRAAAATVGMALGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALIALGGW
LLLGRGLTALTPRSLGVRWAPTVRLGSMYGYGISYAVASLSCTIGPFLAVTGAGLRGG
SVVGSVAIYLAYVAGLTLVVGVLAVAAATASSALADRLRRILPFVNRISGALLVVVGL
YVGYYGLYELRLIAGVGANPQDAVIAAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGA
FAGTWFRRVRR"
gene complement(3188876..3189397)
/gene="mpt53"
/gene_synonym="dsbE"
/locus_tag="Rv2878c"
CDS complement(3188876..3189397)
/codon_start=1
/transl_table=11
/gene="mpt53"
/gene_synonym="dsbE"
/locus_tag="Rv2878c"
/product="Soluble secreted antigen Mpt53 precursor"
/note="Rv2878c, (MT2946, MTCY274.09c), len: 173 aa.
Mpt53,secreted protein (contains N-terminal signal
sequence) (see citations below). Shows some similarity
with several disulfide bond interchange proteins e.g.
P43787|THIX_HAEIN thioredoxin-like protein HI1115 from
Haemophilus influenzae (167 aa), FASTA scores: opt: 200,
E(): 1.4e-06, (28.9% identity in 135 aa overlap);
P52237|TIPB_PSEFL thiol:disulfide interchange protein TIPB
precursor (cytochrome C biogenesis protein TIPB) (178 aa),
FASTA scores: opt: 184, E(): 1.8e-05, (26.3% identity in
171 aa overlap); etc. Also highly similar to
O53924|DSBF|Rv1677|MTV047.12 putative lipoprotein from
Mycobacterium tuberculosis (182 aa), FASTA scores: opt:
482, E(): 5.7e-26, (52.8% identity in 142 aa overlap).
Could be belong to the thioredoxin family. Note that also
previously known as dsbE."
/db_xref="EnsemblGenomes-Gn:Rv2878c"
/db_xref="EnsemblGenomes-Tr:CCP45680"
/db_xref="GOA:P9WG65"
/db_xref="InterPro:IPR000866"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:1LU4"
/db_xref="UniProtKB/Swiss-Prot:P9WG65"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45680.1"
/translation="MSLRLVSPIKAFADGIVAVAIAVVLMFGLANTPRAVAADERLQF
TATTLSGAPFDGASLQGKPAVLWFWTPWCPFCNAEAPSLSQVAAANPAVTFVGIATRA
DVGAMQSFVSKYNLNFTNLNDADGVIWARYNVPWQPAFVFYRADGTSTFVNNPTAAMS
QDELSGRVAALTS"
gene complement(3189583..>3190152)
/locus_tag="Rv2879c"
CDS complement(3189583..>3190152)
/codon_start=1
/transl_table=11
/locus_tag="Rv2879c"
/product="Conserved hypothetical protein"
/note="Rv2879c, (MTCY274.10c), len: 189 aa. Conserved
hypothetical protein, similar to others e.g. C-terminus of
Q9RVT6|DR0936 conserved hypothetical protein from
Deinococcus radiodurans (346 aa), FASTA scores: opt:
505,E(): 1e-26, (46.5% identity in 185 aa overlap);
O34617|YLON_BACSU hypothetical 41.6 KDA protein from
Bacillus subtilis (363 aa), FASTA scores: opt: 459, E():
1.2e-24, (40.5% identity in 185 aa overlap);
YFGB_ECOLI|P36979 hypothetical 43.1 kDa protein from
Escherichia coli (384 aa), FASTA scores, opt: 410, E():
2.8e-21, (41.7% identity in 187 aa overlap); etc. Appears
to be a frame shift with respect to following ORF but we
can detect no error in the cosmid sequence to account for
this."
/db_xref="EnsemblGenomes-Gn:Rv2879c"
/db_xref="EnsemblGenomes-Tr:CCP45681"
/db_xref="GOA:P9WH15"
/db_xref="InterPro:IPR004383"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR027492"
/db_xref="InterPro:IPR040072"
/db_xref="UniProtKB/Swiss-Prot:P9WH15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45681.1"
/translation="WGEPLANYARVLAAVQRITARPPSGFGISARAVTVSTVGLAPAI
RNLADARLGVTLALSLHAPDDGLRDTLVPVNNRWRISEALDAARYYANVTGRRVSIEY
ALIRDVNDQPWRADLLGKRLHRVLGPLAHVNLIPLNPTPGSDWDASPKPVEREFVKRV
RAKGVSCTVRDTRGREISAACGQLAAVGG"
gene complement(3189851..3190678)
/locus_tag="Rv2880c"
CDS complement(3189851..3190678)
/codon_start=1
/transl_table=11
/locus_tag="Rv2880c"
/product="Conserved hypothetical protein"
/note="Rv2880c, (MTCY274.11c), len: 275 aa. Conserved
hypothetical protein, highly similar in N-terminus to
others e.g. O86754|SC6A9.22c hypothetical 40.4 KDA protein
from Streptomyces coelicolor (368 aa), FASTA scores: opt:
663, E(): 2.6e-33, (52.6% identity in 213 aa overlap);
Q55880|Y098_SYNY3|SLL0098 hypothetical 38.9 KDA protein
from Synechocystis sp. strain PCC 6803 (350 aa), FASTA
scores: opt: 362, E(): 7.3e-15, (38.9% identity in 162 aa
overlap); O66732|AQ_416 hypothetical 40.2 KDA protein from
Aquifex aeolicus (348 aa), FASTA scores: opt: 321, E():
2.4e-12, (39.75% identity in 146 aa overlap); etc. Appears
to be a frame shift with respect to preceding ORF but we
can detect no error in the cosmid sequence to account for
this."
/db_xref="EnsemblGenomes-Gn:Rv2880c"
/db_xref="EnsemblGenomes-Tr:CCP45682"
/db_xref="GOA:P9WH15"
/db_xref="InterPro:IPR004383"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR027492"
/db_xref="InterPro:IPR040072"
/db_xref="UniProtKB/Swiss-Prot:P9WH15"
/protein_id="CCP45682.1"
/translation="MVPELMFDEPRPGRPPRHLADLDAAGRASAVAELGLPAFRAKQL
AHQYYGRLIADPRQMTDLPAAVRDRIAGAMFPNLLTASADITCDAGQTRKTLWRAVDG
TMFESVLMRYPRRNTVCISSQAGCGMACPFCATGQGGLTRNLSTAEILEQVRAGAAAL
RDDFGDRLSNVVFMGMGGAAGQLRQGVGRSSAHYRAAAVRFRDFGPRGDGVDGGSGPC
YPQPCRRAARRDPGAVAARPRRRVARYTSSGQQPVEDQRSARCGPVLRQCDRATGVY"
gene complement(3190701..3191621)
/gene="cdsA"
/locus_tag="Rv2881c"
CDS complement(3190701..3191621)
/codon_start=1
/transl_table=11
/gene="cdsA"
/locus_tag="Rv2881c"
/product="Probable integral membrane phosphatidate
cytidylyltransferase CdsA (CDP-diglyceride synthetase)
(CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol
synthase) (CDS) (CTP:phosphatidate cytidylyltransferase)
(CDP-DAG synthase) (CDP-DG synthetase)"
/note="Rv2881c, (MTCY274.12c), len: 306 aa. Probable
cdsA,phosphatidate cytidylyltransferase, integral membrane
protein, equivalent to Q9CBU1|CDSA_MYCLE|ML1589
phosphatidate cytidylyltransferase from Mycobacterium
leprae (312 aa), FASTA scores: opt: 1470, E():
1.1e-84,(70.3% identity in 313 aa overlap). Also similar
to others e.g. Q9KPV7|VC2255 from Vibrio cholerae (280
aa), FASTA scores: opt: 383, E(): 1.1e-16, (29.3% identity
in 280 aa overlap); Q9CDT2|CDSA from Lactococcus lactis
(subsp. lactis) (Streptococcus lactis) (267 aa), FASTA
scores: opt: 361, E(): 2.6e-15, (29.05% identity in 265 aa
overlap); P06466|CDSA_ECOLI|CDS|B0175|Z0186|ECS0177 from
Escherichia coli strains K12 and O157:H7 (249 aa), FASTA
scores: opt: 352, E(): 9.2e-15, (40.4% identity in 156 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Belongs to the CDS family."
/db_xref="EnsemblGenomes-Gn:Rv2881c"
/db_xref="EnsemblGenomes-Tr:CCP45683"
/db_xref="GOA:P9WPF7"
/db_xref="InterPro:IPR000374"
/db_xref="UniProtKB/Swiss-Prot:P9WPF7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45683.1"
/translation="MTTNDAGTGNPAEQPARGAKQQPATETSRAGRDLRAAIVVGLSI
GLVLIAVLVFVPRVWVAIVAVATLVATHEVVRRLREAGYLIPVIPLLIGGQAAVWLTW
PFGAVGALAGFGGMVVVCMIWRLFMQDSVTRPTTGGAPSPGNYLSDVSATVFLAVWVP
LFCSFGAMLVYPENGSGWVFCMMIAVIASDVGGYAVGVLFGKHPMVPTISPKKSWEGF
AGSLVCGITATIITATFLVGKTPWIGALLGVLFVLTTALGDLVESQVKRDLGIKDMGR
LLPGHGGLMDRLDGILPSAVAAWIVLTLLP"
gene complement(3191644..3192201)
/gene="frr"
/locus_tag="Rv2882c"
CDS complement(3191644..3192201)
/codon_start=1
/transl_table=11
/gene="frr"
/locus_tag="Rv2882c"
/product="Ribosome recycling factor Frr (ribosome
releasing factor) (RRF)"
/note="Rv2882c, (MTCY274.13c), len: 185 aa. Probable
frr,ribosome recycling factor, equivalent to
O33046|RRF_MYCLE|FRR|ML1590|MLCB250.76 ribosome recycling
factor from Mycobacterium leprae (185 aa), FASTA scores:
opt: 1063, E(): 2.6e-60, (90.8% identity in 185 aa
overlap). Also highly similar to others e.g.
O86770|RRF_STRCO|FRR|SC6A9.40c from Streptomyces
coelicolor (185 aa), FASTA scores: opt: 783, E(): 1.5e-42,
(63.25% identity in 185 aa overlap); P81101|RRF_BACSU|FRR
from Bacillus subtilis (184 aa), FASTA scores: opt: 640,
E(): 1.7e-33, (51.65% identity in 182 aa overlap);
P16174|RRF_ECOLI|FRR|B0172|Z0183|ECS0174 from Escherichia
coli strains K12 and O157:H7 (185 aa), FASTA scores: opt:
473, E(): 1.4e-23, (40.2% identity in 184 aa overlap);
etc. Belongs to the RRF family."
/db_xref="EnsemblGenomes-Gn:Rv2882c"
/db_xref="EnsemblGenomes-Tr:CCP45684"
/db_xref="GOA:P9WGY1"
/db_xref="InterPro:IPR002661"
/db_xref="InterPro:IPR023584"
/db_xref="InterPro:IPR036191"
/db_xref="PDB:1WQF"
/db_xref="PDB:1WQG"
/db_xref="PDB:1WQH"
/db_xref="PDB:4KAW"
/db_xref="PDB:4KB2"
/db_xref="PDB:4KB4"
/db_xref="PDB:4KC6"
/db_xref="PDB:4KDD"
/db_xref="UniProtKB/Swiss-Prot:P9WGY1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45684.1"
/translation="MIDEALFDAEEKMEKAVAVARDDLSTIRTGRANPGMFSRITIDY
YGAATPITQLASINVPEARLVVIKPYEANQLRAIETAIRNSDLGVNPTNDGALIRVAV
PQLTEERRRELVKQAKHKGEEAKVSVRNIRRKAMEELHRIRKEGEAGEDEVGRAEKDL
DKTTHQYVTQIDELVKHKEGELLEV"
repeat_region complement(3192202..3192254)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(3192255..3192307)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region complement(3192308..3192360)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene complement(3192373..3193158)
/gene="pyrH"
/locus_tag="Rv2883c"
CDS complement(3192373..3193158)
/codon_start=1
/transl_table=11
/gene="pyrH"
/locus_tag="Rv2883c"
/product="Probable uridylate kinase PyrH (UK) (uridine
monophosphate kinase) (UMP kinase)"
/note="Rv2883c, (MT2951, MTCY274.14c), len: 261 aa.
Probable pyrH, uridylate kinase, equivalent to
O33045|PYRH_MYCLE|ML1591|MLCB250.75 uridylate kinase from
Mycobacterium leprae (279 aa), FASTA scores: opt:
1437,E(): 3.8e-81, (85.05% identity in 274 aa overlap).
Also highly similar to others e.g. O69913|PYRH from
Streptomyces coelicolor (253 aa), FASTA scores: opt: 1086,
E(): 1.4e-59,(68.9% identity in 251 aa overlap);
P74457|PYRH_SYNY3|SLL0144 from Synechocystis sp. strain
PCC 6803 (260 aa), FASTA scores: opt: 851, E():
4.1e-45,(55.85% identity in 231 aa overlap);
P29464|PYRH_ECOLI|SMBA|B0171|Z0182|ECS0173 from strains
K12 and O157:H7 (240 aa), FASTA scores: opt: 666, E():
1.1e-35,(45.7% identity in 232 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2883c"
/db_xref="EnsemblGenomes-Tr:CCP45685"
/db_xref="GOA:P9WHK5"
/db_xref="InterPro:IPR001048"
/db_xref="InterPro:IPR011817"
/db_xref="InterPro:IPR015963"
/db_xref="InterPro:IPR036393"
/db_xref="PDB:3NWY"
/db_xref="UniProtKB/Swiss-Prot:P9WHK5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45685.1"
/translation="MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGG
GQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFFRGAQLQQLGMERTRSDYMGML
GTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGL
PYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLR
VADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT"
gene 3193393..3194151
/locus_tag="Rv2884"
CDS 3193393..3194151
/codon_start=1
/transl_table=11
/locus_tag="Rv2884"
/product="Probable transcriptional regulatory protein"
/note="Rv2884, (MTCY274.15), len: 252 aa. Probable
transcriptional regulatory protein, highly similar to
others e.g. Q05943|GLNR_STRCO|SCD84.26c transcriptional
regulatory protein from Streptomyces coelicolor (267
aa),FASTA scores: opt: 609, E(): 2.7e-34, (46.4% identity
in 224 aa overlap); Q55733|SLL0396 regulatory components
of sensory transduction system from Synechocystis sp.
strain PCC 6803 (224 aa), FASTA scores: opt: 330, E():
3e-15,(31.8% identity in 217 aa overlap); Q9A4S3|CC2757
DNA-binding response regulator from Caulobacter crescentus
(223 aa), FASTA scores: opt: 311, E(): 6e-14, (30.3%
identity in 221 aa overlap); etc. Also highly similar to
O53830|Rv0818|MTV043.10 putative regulatory protein from
Mycobacterium tuberculosis (255 aa), FASTA scores: opt:
665, E(): 3.8e-38, (47.6% identity in 227 aa overlap). The
N-terminal region is similar to that of other regulatory
components of sensory transduction systems."
/db_xref="EnsemblGenomes-Gn:Rv2884"
/db_xref="EnsemblGenomes-Tr:CCP45686"
/db_xref="GOA:I6X5M3"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="UniProtKB/TrEMBL:I6X5M3"
/protein_id="CCP45686.1"
/translation="MPTGPTTGKWHPHEVWRYLLEVLLLTDEADLESALPELESFAQS
VQRAPLDDPGAAKGADADVAIIDARADLAAARRVCRRLTTSAPALAVVAVVAPANFVA
VDGDWIFDDVLLNAAGGAELQARLRLAITRRRSTLAGTLQFGDLVLHPASYTASLGDR
DLGLTLTEFKLMNFLVQHAGRAFTRTRLMREVWGYECHGRIRTVDVHVRRLRAKLGAE
HESMIDTVRGVGYMAVTPPQPRWIISESILNRCK"
mobile_element complement(3194166..3196432)
/mobile_element_type="insertion sequence:IS1539"
/note="IS1539, len: 2267 nt. Insertion sequence IS1539."
gene complement(3194166..3195548)
/locus_tag="Rv2885c"
CDS complement(3194166..3195548)
/codon_start=1
/transl_table=11
/locus_tag="Rv2885c"
/product="Probable transposase"
/note="Rv2885c, (MTCY274.16c), len: 460 aa. Probable
transposase for IS1539. Contains PS00017 ATP/GTP-binding
site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2885c"
/db_xref="EnsemblGenomes-Tr:CCP45687"
/db_xref="GOA:P9WL37"
/db_xref="InterPro:IPR001959"
/db_xref="InterPro:IPR010095"
/db_xref="InterPro:IPR021027"
/db_xref="UniProtKB/Swiss-Prot:P9WL37"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45687.1"
/translation="MMARLKVPEGWCVQAFRFTLNPTQTQAASLARHFGARRKAFNWT
VTALKADIKAWRADGTESAKPSLRVLRKRWNTVKDQVCVNAQTGQVWWPECSKEAYAD
GIAGAVDAYWNWQSCRAGKRAGKTVGVPRFKKKGRDADRVCFTTGAMRVEPDRRHLTL
PVIGTIRTYENTRRVERLIAKGRARVLAITVRRNGTRLDASVRVLVQRPQQRRVALPD
SRVGVDVGVRRLATVADAEGTVLEQVPNPRPLDAALRGLRRVSRARSRCTKGSRRYCE
RTTELSRLHRRVNDVRTHHLHVLTTRLAKTHGRIVVEGLDAAGMLRQKGLPGARARRR
ALSDAALATPRRHLSYKTGWYGSSLVVADRWFPSSKTCHACRHVQDIGWDEKWQCDGC
SITHQRDDNAAINLARYEEPPSVVGPVGAAVKRGADRKTGPGPAGGREARKATGHPAG
EQPRDGVQVK"
gene complement(3195545..3196432)
/locus_tag="Rv2886c"
CDS complement(3195545..3196432)
/codon_start=1
/transl_table=11
/locus_tag="Rv2886c"
/product="Probable resolvase"
/note="Rv2886c, (MTCY274.17c), len: 295 aa. Probable
resolvase for IS1539. Contains PS00213 Lipocalin
signature."
/db_xref="EnsemblGenomes-Gn:Rv2886c"
/db_xref="EnsemblGenomes-Tr:CCP45688"
/db_xref="GOA:P9WL35"
/db_xref="InterPro:IPR006119"
/db_xref="InterPro:IPR036162"
/db_xref="UniProtKB/Swiss-Prot:P9WL35"
/inference="protein motif:PROSITE:PS00213"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45688.1"
/translation="MSRILTHVPGRTVNRSYALPALVGSAAGRLSGNHSHGREAYIAL
PQWACSRQPSTPPLQTPGRINALWSLRPVLPMPGRGCQLLRLGGRWLSVVCCRNGSMN
LVVWAEGNGVARVIAYRWLRVGRLPVPARRVGRVILVDEPAGQPGRWGRTAVCARLSS
ADQKVDLDRQVVGVTAWATAEQIPVGKVVTEVGSALYGRRRTFLTLLGDPTVRRIVMK
RRDRLGRFGFECVQAVLAADGRELVVVDSADVDDDVVGDITEILTSICARLYGKRAAG
NRAARAVAAAARAGGHEAR"
gene 3196431..3196850
/locus_tag="Rv2887"
CDS 3196431..3196850
/codon_start=1
/transl_table=11
/locus_tag="Rv2887"
/product="Probable transcriptional regulatory protein"
/note="Rv2887, (MTCY274.18), len: 139 aa. Probable
transcriptional regulatory protein, highly similar to
Q9EX59|SC1A4.04 putative MarR-family transcriptional
regulator from Streptomyces coelicolor (151 aa), FASTA
scores: opt: 354, E(): 6.6e-16, (42.95% identity in 135 aa
overlap); and similar to others e.g. AAF97817|SLYA
transcriptional regulator SLYA from Escherichia coli
strain EPEC 2348/69 (146 aa), FASTA scores: opt: 181, E():
0.0001,(27.25% identity in 132 aa overlap);
P55740|SLYA_ECOLI|AAG56631|B1642|Z2657|ECS2351
transcriptional regulator SLYA from Escherichia coli
strains K12 and O157:H7 (146 aa), FASTA scores: opt:
177,E(): 0.00018, (27.25% identity in 132 aa overlap) ;
etc. Contains probable helix-turn-helix motif at aa 50-71
(Score 1182, +3.21 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2887"
/db_xref="EnsemblGenomes-Tr:CCP45689"
/db_xref="GOA:P9WME9"
/db_xref="InterPro:IPR000835"
/db_xref="InterPro:IPR023187"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:5HSM"
/db_xref="PDB:5HSO"
/db_xref="PDB:5X7Z"
/db_xref="PDB:5X80"
/db_xref="UniProtKB/Swiss-Prot:P9WME9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45689.1"
/translation="MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRML
SQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRAL
AKRAEAVVRAADARVLARLTAPQQREFKRMLEKLGSD"
gene complement(3196864..3198285)
/gene="amiC"
/locus_tag="Rv2888c"
CDS complement(3196864..3198285)
/codon_start=1
/transl_table=11
/gene="amiC"
/locus_tag="Rv2888c"
/product="Probable amidase AmiC (aminohydrolase)"
/note="Rv2888c, (MTCY274.19c), len: 473 aa. Probable
amiC,amidase, equivalent to
O33040|AMI3_MYCLE|AMIC|ML1596|MLCB250.65 putative amidase
AMIC from Mycobacterium leprae (468 aa), FASTA scores:
opt: 2361, E(): 4.2e-139, (76.7% identity in 468 aa
overlap). Also similar to others e.g. Q9A8N0|CC1323
putative 6-aminohexanoate-cyclic-dimer hydrolase from
Caulobacter crescentus (521 aa), FASTA scores: opt: 925,
E(): 7.4e-50,(36.55% identity in 465 aa overlap);
O28325|YJ54_ARCFU|AF1954 putative amidase from
Archaeoglobus fulgidus (453 aa), FASTA scores: opt:
659,E(): 2.2e-33, (31.1% identity in 460 aa overlap);
Q55424|AMID_SYNY3|SLL0828 putative amidase from
Synechocystis sp. strain PCC 6803 (506 aa), FASTA scores:
opt: 643, E(): 2.4e-32, (30.7% identity in 466 aa
overlap); etc. Also similar to
O05835|AMI1_MYCTU|AMIA2|Rv2363|MT2432|MTCY27.17c putative
amidase AMIA2 (484 aa), FASTA scores: opt: 656, E():
3.6e-33, (35.9% identity in 465 aa overlap); and
Q11056|AMI2_MYCTU|AMIB2|Rv1263|MT1301|MTCY50.19c putative
amidase from Mycobacterium tuberculosis (462 aa), FASTA
scores: opt: 650, E(): 8.2e-33, (33.45% identity in 472 aa
overlap). Contains PS00017 ATP/GTP-binding site motif A
(P-poop). Belongs to the amidase family."
/db_xref="EnsemblGenomes-Gn:Rv2888c"
/db_xref="EnsemblGenomes-Tr:CCP45690"
/db_xref="GOA:P9WQ95"
/db_xref="InterPro:IPR000120"
/db_xref="InterPro:IPR020556"
/db_xref="InterPro:IPR023631"
/db_xref="InterPro:IPR036928"
/db_xref="UniProtKB/Swiss-Prot:P9WQ95"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45690.1"
/translation="MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEA
VNPALNALAYAAFDVARDAAAMGTGQEAFFSGVPTFIKDNVDVAGQPSMHGTDAWEPY
AAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNPWNTDYTAGASSSG
SGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPSRGRLPLEPEYRRLPVGIVANG
VLTRTVRDTAAFYREAERLWRNHQLPPVGDVTSPVKQRLRIAVVTRSVLREASPEVRQ
LTLKLAGLLEELGHRVEHVDHPPAPASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPT
RLDELTLGLARHTGRNLHRLPLAIMRLRMLRRRSVRFFGTYDVLLTPTVAEATPQVGY
LAPTDYQTVLDRLSSWVVFTPVQNVTGVPAISLPLAQSADGMPVGMMLSADTGREALL
LELAYELEEARPWARIHAPNIAE"
gene complement(3198292..3199107)
/gene="tsf"
/locus_tag="Rv2889c"
CDS complement(3198292..3199107)
/codon_start=1
/transl_table=11
/gene="tsf"
/locus_tag="Rv2889c"
/product="Probable elongation factor Tsf (EF-ts)"
/note="Rv2889c, (MTCY274.20c), len: 271 aa. Probable
tsf,elongation factor, equivalent to
O33039|EFTS_MYCLE|TSF|ML1597|MLCB250.64 elongation factor
from Mycobacterium leprae (276 aa), FASTA scores: opt:
1430, E(): 1.9e-80, (83.7% identity in 276 aa overlap).
Also highly similar to others e.g. Q9X5Z9|EFTS_STRRA|TSF
from Streptomyces ramocissimus (278 aa), FASTA scores:
opt: 928, E(): 1.1e-49, (57.05% identity in 277 aa
overlap); O31213|EFTS_STRCO|TSF|SC2E1.42 from Streptomyces
coelicolor (278 aa), FASTA scores: opt: 927, E(): 1.3e-49,
(56.3% identity in 277 aa overlap); P80700|EFTS_BACSU|TSF
from Bacillus subtilis (292 aa), FASTA scores: opt: 650,
E(): 1.3e-32, (43.85% identity in 276 aa overlap); etc.
Contains PS01127 Elongation factor Ts signature 2. Belongs
to the EF-ts family."
/db_xref="EnsemblGenomes-Gn:Rv2889c"
/db_xref="EnsemblGenomes-Tr:CCP45691"
/db_xref="GOA:P9WNM1"
/db_xref="InterPro:IPR001816"
/db_xref="InterPro:IPR009060"
/db_xref="InterPro:IPR014039"
/db_xref="InterPro:IPR018101"
/db_xref="InterPro:IPR036402"
/db_xref="UniProtKB/Swiss-Prot:P9WNM1"
/inference="protein motif:PROSITE:PS01127"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45691.1"
/translation="MANFTAADVKRLRELTGAGMLACKNALAETDGDFDKAVEALRIK
GAKDVGKRAERATAEGLVAAKDGALIELNCETDFVAKNAEFQTLADQVVAAAAAAKPA
DVDALKGASIGDKTVEQAIAELSAKIGEKLELRRVAIFDGTVEAYLHRRSADLPPAVG
VLVEYRGDDAAAAHAVALQIAALRARYLSRDDVPEDIVASERRIAEETARAEGKPEQA
LPKIVEGRLNGFFKDAVLLEQASVSDNKKTVKALLDVAGVTVTRFVRFEVGQA"
gene complement(3199119..3199982)
/gene="rpsB"
/locus_tag="Rv2890c"
CDS complement(3199119..3199982)
/codon_start=1
/transl_table=11
/gene="rpsB"
/locus_tag="Rv2890c"
/product="30S ribosomal protein S2 RpsB"
/note="Rv2890c, (MTCY274.21c), len: 287 aa. rpsB, 30s
ribosomal protein s2, equivalent to
O33038|RS2_MYCLE|RPSB|ML1598|MLCB250.63 30S ribosomal
protein S2 from Mycobacterium leprae (277 aa), FASTA
scores: opt: 1593, E(): 2.3e-93, (91.5% identity in 270 aa
overlap). Also highly similar to others e.g.
O31212|RS2_STRCO|RPSB|SC2E1.41 from Streptomyces
coelicolor (310 aa), FASTA scores: opt: 1302, E():
6.1e-75, (70.6% identity in 289 aa overlap);
Q9KA63|RPSB|BH2427 from Bacillus halodurans (244 aa),
FASTA scores: opt: 991, E(): 2.3e-55, (59.6% identity in
255 aa overlap); P21464|RS2_BACSU|RPSB from Bacillus
subtilis (245 aa),FASTA scores: opt: 959, E(): 2.4e-53,
(58.55% identity in 246 aa overlap); etc. Contains PS00962
Ribosomal protein S2 signature 1. Belongs to the S2P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv2890c"
/db_xref="EnsemblGenomes-Tr:CCP45692"
/db_xref="GOA:P9WH39"
/db_xref="InterPro:IPR001865"
/db_xref="InterPro:IPR005706"
/db_xref="InterPro:IPR018130"
/db_xref="InterPro:IPR023591"
/db_xref="UniProtKB/Swiss-Prot:P9WH39"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00962"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45692.1"
/translation="MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQ
QTLTFIDKAYEFVKETVAHGGSVLFVGTKKQAQESVAAEATRVGMPYVNQRWLGGMLT
NFSTVHKRLQRLKELEAMEQTGGFEGRTKKEILGLTREKNKLERSLGGIRDMAKVPSA
IWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDEVDYPIPGNDDAIRSAALLTRVIA
SAVAEGLQARAGLGRADGKPEAEAAEPLAEWEQELLASATASATPSATASTTALTDAP
AGATEPTTDAS"
gene 3200266..3201015
/locus_tag="Rv2891"
CDS 3200266..3201015
/codon_start=1
/transl_table=11
/locus_tag="Rv2891"
/product="Conserved hypothetical protein"
/note="Rv2891, (MTCY274.22), len: 249 aa (C-terminus
overlaps neigbouring ORF). Conserved hypothetical
protein,similar in N-terminus to O69910|SC2E1.40c
hypothetical 22.8 KDA protein from Streptomyces coelicolor
(226 aa), FASTA scores: opt: 315, E(): 3.4e-11, (40.7%
identity in 145 aa overlap). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2891"
/db_xref="EnsemblGenomes-Tr:CCP45693"
/db_xref="InterPro:IPR011055"
/db_xref="InterPro:IPR016047"
/db_xref="UniProtKB/Swiss-Prot:P9WL33"
/protein_id="CCP45693.1"
/translation="MAKSPARRCTAKVRRVLSRSVLILCWSLLGAAPAHADDSRLGWP
LRPPPAVVRQFDAASPNWNPGHRGVDLAGRPGQPVYAAGSATVVFAGLLAGRPVVSLA
HPGGLRTSYEPVVAQVRVGQPVSAPTVIGALAAGHPGCQAAACLHWGAMWGPASGANY
VDPLGLLKSTPIRLKPLSSEGRTLHYRQAEPVFVNEAAAGALAGAGHRKSPKQGVFRG
AAQGGDIVARQPPGRWVCPSSAGGPIGWHRQ"
gene complement(3200794..3202020)
/gene="PPE45"
/locus_tag="Rv2892c"
CDS complement(3200794..3202020)
/codon_start=1
/transl_table=11
/gene="PPE45"
/locus_tag="Rv2892c"
/product="PPE family protein PPE45"
/note="Rv2892c, (MTCY274.23c), len: 408 aa. PPE45, Member
of the Mycobacterium tuberculosis PPE family, highly
similar to many e.g.
O06386|Rv3621c|MTCY15C10.31|MTCY07H7B.01 from M.
tuberculosis (413 aa), FASTA scores: opt: 957, E():
6.2e-46, (44.7% identity in 423 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2892c"
/db_xref="EnsemblGenomes-Tr:CCP45694"
/db_xref="GOA:P9WHZ1"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45694.1"
/translation="MDFGVLPPEINSGRMYAGPGSGPMMAAAAAWDSLAAELGLAAGG
YRLAISELTGAYWAGPAAASMVAAVTPYVAWLSATAGQAEQAGMQARAAAAAYELAFA
MTVPPPVVVANRALLVALVATNFFGQNTPAIAATEAQYAEMWAQDAAAMYAYAGSAAI
ATELTPFTAAPVTTSPAALAGQAAATVSSTVPPLATTAAVPQLLQQLSSTSLIPWYSA
LQQWLAENLLGLTPDNRMTIVRLLGISYFDEGLLQFEASLAQQAIPGTPGGAGDSGSS
VLDSWGPTIFAGPRASPSVAGGGAVGGVQTPQPYWYWALDRESIGGSVSAALGKGSSA
GSLSVPPDWAARARWANPAAWRLPGDDVTALRGTAENALLRGFPMASAGQSTGGGFVH
KYGFRLAVMQRPPFAG"
gene 3202420..3203397
/locus_tag="Rv2893"
CDS 3202420..3203397
/codon_start=1
/transl_table=11
/locus_tag="Rv2893"
/product="Possible oxidoreductase"
/note="Rv2893, (MTCY274.24), len: 325 aa. Possible
oxidoreductase, showing similarity with various proteins
and/or oxidoreductases e.g. Q9AE05|RIF11 eleventh protein
in the rif biosynthetic gene cluster from Amycolatopsis
mediterranei (Nocardia mediterranei) (294 aa), FASTA
scores: opt: 270, E(): 4.8e-10, (34.5% identity in 313 aa
overlap); O52567 reductase from Amycolatopsis mediterranei
(Nocardia mediterranei) (153 aa), FASTA scores: opt:
251,E(): 5e-09, (42.4% identity in 125 aa overlap);
Q58929|mer|MJ1534 F420-dependent
methylenetetrahydromethanopterin reductase from
Methanococcus jannaschii (331 aa), FASTA scores: opt:
249,E(): 1.2e-08, (29.7% identity in 283 aa overlap); etc.
Also some similarity with others proteins from
Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g.
P71844|Rv0791c|MTCY369.35c putative oxidoreductase (347
aa), FASTA scores: opt: 264, E(): 1.3e-09, (29.05%
identity in 272 aa overlap); and P96809|Rv0132|MTCI5.06c
putative oxidoreductase (360 aa), FASTA scores: opt: 260,
E(): 2.4e-09, (33.05% identity in 239 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2893"
/db_xref="EnsemblGenomes-Tr:CCP45695"
/db_xref="GOA:I6YEN3"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019923"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:I6YEN3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45695.1"
/translation="MTVASTAHHTRRLRFGLAAPLPRAGTQMRAFAQAVEAAGFDVLA
FPDHLVPSVSPFAGATAAAMATQRLHTGTLVLNNDFRHPVDTAREAAGVATLAEGRFE
LGLGAGHRRSEYDAAGITFDSGATRVARLIESAHLIRALLDAEPVDFDGQHYRVHAEA
GSLVAPPKVRVPLLVGGNGTEVLRLGGRIADIVGLAGISHNRDATQVRFTHFDADGLA
DRIAVVRHAAGDRFEAIELNALIQAVVCTNDRNAAAAELAATLGGITPEQVLESPFLL
LGTHEQMAEALAARQRRFGVSYWTVFDEWAGRASAMRDIAEVIALLRYG"
gene complement(3203394..3204290)
/gene="xerC"
/locus_tag="Rv2894c"
CDS complement(3203394..3204290)
/codon_start=1
/transl_table=11
/gene="xerC"
/locus_tag="Rv2894c"
/product="Probable integrase/recombinase XerC"
/note="Rv2894c, (MTCY274.25c), len: 298 aa. Probable
xerC,integrase/recombinase, equivalent to
Q9CBU0|XERC|ML1600|MLCB250.62 integrase/recombinase from
Mycobacterium leprae (297 aa), FASTA scores: opt:
1624,E(): 2e-97, (85.15% identity in 296 aa overlap). Also
highly similar to others integrases/recombinases
(generally xerC and xerD) e.g. Q9HTS4|SSS|PA5280
site-specific recombinase from Pseudomonas aeruginosa (303
aa), FASTA scores: opt: 660, E(): 3.2e-35, (41.8% identity
in 299 aa overlap); Q9HXQ6|XERD|PA3738
integrase/recombinase from Pseudomonas aeruginosa (298
aa), FASTA scores: opt: 656,E(): 5.7e-35, (40.05% identity
in 297 aa overlap); Q9KCP0|BH1529 integrase/recombinase
from Bacillus halodurans (299 aa), FASTA scores: opt: 645,
E(): 2.9e-34,(37.35% identity in 300 aa overlap); etc.
Also similar to O33200|Rv1701|MTCI125.23
integrase/recombinase from Mycobacterium tuberculosis (311
aa), FASTA scores: opt: 646, E(): 2.6e-34, (43.1% identity
in 304 aa overlap). Belongs to the 'phage' integrase
family."
/db_xref="EnsemblGenomes-Gn:Rv2894c"
/db_xref="EnsemblGenomes-Tr:CCP45696"
/db_xref="GOA:P9WF35"
/db_xref="InterPro:IPR002104"
/db_xref="InterPro:IPR004107"
/db_xref="InterPro:IPR010998"
/db_xref="InterPro:IPR011010"
/db_xref="InterPro:IPR013762"
/db_xref="InterPro:IPR023009"
/db_xref="UniProtKB/Swiss-Prot:P9WF35"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45696.1"
/translation="MQAILDEFDEYLALQCGRSVHTRRAYLGDLRSLFAFLADRGSSL
DALTLSVLRSWLAATAGAGAARTTLARRTSAVKAFTAWAVRRGLLAGDPAARLQVPKA
RRTLPAVLRQDQALRAMAAAESGAEQGDPLALRDRLIVELLYATGIRVSELCGLDVDD
IDTGHRLVRVLGKGNKQRTVPFGQPAADALHAWLVDGRRALVTAESGHALLLGARGRR
LDVRQARTAVHQTVAAVDGAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATT
QLYTHVAVARLRAVHERAHPRA"
gene complement(3204381..3205232)
/gene="viuB"
/locus_tag="Rv2895c"
CDS complement(3204381..3205232)
/codon_start=1
/transl_table=11
/gene="viuB"
/locus_tag="Rv2895c"
/product="Possible mycobactin utilization protein ViuB"
/note="Rv2895c, (MT2963, MTCY274.26c), len: 283 aa.
Possible viuB, mycobactin utilization protein, highly
similar to Q9RJ78|SCI41.06 hypothetical 31.5 KDA protein
from Streptomyces coelicolor (280 aa), FASTA scores: opt:
639, E(): 5.1e-32, (46.3% identity in 285 aa overlap); and
similar to other proteins e.g. Q9F641|MXCB protein of the
biosynthetic gene cluster of the myxochelin-type iron
chelator from Stigmatella aurantiaca (270 aa), FASTA
scores: opt: 417, E(): 2.2e-18, (34.2% identity in 263 aa
overlap); Q56646|VIUB_VIBCH|VC2210 vibriobactin
utilization protein from Vibrio cholerae (271 aa), FASTA
scores: opt: 395, E(): 5.1e-17, (31.0% identity in 274 aa
overlap); Q56743|VIUB_VIBVU vulnibactin utilization
protein V from Vibrio vulnificus (271 aa), FASTA scores:
opt: 390, E(): 1e-16, (33.95% identity in 274 aa overlap);
etc. Equivalent to AAK47289 from Mycobacterium
tuberculosis strain CDC1551 (321 aa) but shorter 38 aa."
/db_xref="EnsemblGenomes-Gn:Rv2895c"
/db_xref="EnsemblGenomes-Tr:CCP45697"
/db_xref="GOA:P9WL31"
/db_xref="InterPro:IPR007037"
/db_xref="InterPro:IPR013113"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR039261"
/db_xref="InterPro:IPR039374"
/db_xref="UniProtKB/Swiss-Prot:P9WL31"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45697.1"
/translation="MAGRPLHAFEVVATRHLAPHMVRVVLGGSGFDTFVPSDFTDSYI
KLVFVDDDVDVGRLPRPLTLDSFADLPTAKRPPVRTMTVRHVDAAAREIAVDIVLHGE
HGVAGPWAAGAQRGQPIYLMGPGGAYAPDPAADWHLLAGDESAIPAIAAALEALPPDA
IGRAFIEVAGPDDEIGLTAPDAVEVNWVYRGGRADLVPEDRAGDHAPLIEAVTTTAWL
PGQVHVFIHGEAQAVMHNLRPYVRNERGVDAKWASSISGYWRRGRTEEMFRKWKKELA
EAEAGTH"
gene complement(3205265..3206434)
/locus_tag="Rv2896c"
CDS complement(3205265..3206434)
/codon_start=1
/transl_table=11
/locus_tag="Rv2896c"
/product="Conserved hypothetical protein"
/note="Rv2896c, (MTCY274.27c), len: 389 aa. Conserved
hypothetical protein, similar to others proteins e.g.
Q9ZJ08|FIR2 from Rhodococcus fascians (293 aa), FASTA
scores: opt: 663, E(): 3.3e-32, (43.7% identity in 286 aa
overlap); O69892|SC2E1.21 hypothetical 37.9 KDA protein
from Streptomyces coelicolor (382 aa), FASTA scores: opt:
600, E(): 2.2e-28, (46.45% identity in 267 aa overlap);
Q9JWZ4|DPRA|NMA0158 DPRA homolog from Neisseria
meningitidis (serogroup A) (395 aa), FASTA scores: opt:
495, E(): 4.1e-22, (34.6% identity in 347 aa overlap);
etc. Nucleotide position 3205978 in the genome sequence
has been corrected, A:C resulting in S153A."
/db_xref="EnsemblGenomes-Gn:Rv2896c"
/db_xref="EnsemblGenomes-Tr:CCP45698"
/db_xref="GOA:P9WL29"
/db_xref="InterPro:IPR003488"
/db_xref="InterPro:IPR041614"
/db_xref="UniProtKB/Swiss-Prot:P9WL29"
/protein_id="CCP45698.1"
/translation="MIDPTARAWAYLSRVAEPPCAQLAALVRCVGPVEAADRVRRGQV
GNELAQHTGARREIDRAADDLELLMRRGGRLITPDDDEWPVLAFAAFSGAGARARPCG
HSPLVLWALGPARLDEVAPRAAAVVGTRAATAYGEHVAADLAAGLAERDVAVVSGGAY
GIDGAAHRAALDSEGITVAVLAGGFDIPYPAGHSALLHRIAQHGVLFTEYPPGVRPAR
HRFLTRNRLVAAVARAAVVVEAGLRSGAANTAAWARALGRVVAAVPGPVTSSASAGCH
TLLRHGAELVTRADDIVEFVGHIGELAGDEPRPGAALDVLSEAERQVYEALPGRGAAT
IDEIAVGSGLLPAQVLGPLAILEVAGLAECRDGRWRILRAGAGQAAAKGAAARLV"
gene complement(3206431..3207942)
/locus_tag="Rv2897c"
CDS complement(3206431..3207942)
/codon_start=1
/transl_table=11
/locus_tag="Rv2897c"
/product="Conserved hypothetical protein"
/note="Rv2897c, (MTCY274.28c), len: 503 aa. Conserved
hypothetical protein, possibly Mg-chelatase, highly
similar to hypothetical proteins and chelatases e.g.
Q9RTV0|DR1656 mg(2+) chelatase family protein from
Deinococcus radiodurans (519 aa), FASTA scores: opt: 1333,
E(): 3.6e-68, (46.55% identity in 505 aa
overlap);Q55372|SLR0904 hypothetical 55.1 KDA protein from
Synechocystis sp. strain PCC 6803 (509 aa), FASTA scores:
opt: 1271, E(): 1.2e-64,(42.65% identity in 504 aa
overlap); Q9HTR4|PA5290 hypothetical protein from
Pseudomonas aeruginosa (497 aa),FASTA scores: opt: 1248,
E(): 2.3e-63, (45.9% identity in 503 aa overlap);
Q9K0Z6|comm|NMB0405 competence protein (mg-chelatase) from
Neisseria meningitidis (serogroup B),FASTA scores: opt:
1229, E(): 2.8e-62, (43.2% identity in 509 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2897c"
/db_xref="EnsemblGenomes-Tr:CCP45699"
/db_xref="GOA:P9WPR1"
/db_xref="InterPro:IPR000523"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004482"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR025158"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WPR1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45699.1"
/translation="MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQE
SRDRVRAAVTNCGNSWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLE
NTLLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRT
LGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTG
PPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSS
VAALVGGGSGMARPGAVSRAHRGVLFLDECAEISLSALEALRTPLEDGEIRLARRDGV
ACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLDRVDLRVQMHRLR
AGAFSAADGESTSQVRQRVALAREAAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAML
PLRTALDRGLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR"
gene complement(3207942..3208328)
/locus_tag="Rv2898c"
CDS complement(3207942..3208328)
/codon_start=1
/transl_table=11
/locus_tag="Rv2898c"
/product="Conserved hypothetical protein"
/note="Rv2898c, (MTCY274.29c), len: 128 aa. Conserved
hypothetical protein, highly similar to
O33024|YS98_MYCLE|ML1607|MLCB250.49 hypothetical 11.0 KDA
protein from Mycobacterium leprae (96 aa), FASTA scores:
opt: 318, E(): 2.3e-16, (58.35% identity in 96 aa
overlap). Also similar to other hypothetical proteins e.g.
O69890|YE19_STRCO|SC2E1.19 from Streptomyces coelicolor
(130 aa), FASTA scores: opt: 253, E(): 1.7e-11, (39.65%
identity in 121 aa overlap); Q9HVZ1|PA4424 from
Pseudomonas aeruginosa (125 aa), FASTA scores: opt: 234,
E(): 4.2e-10,(40.85% identity in 115 aa overlap); O86871
from Streptomyces lividans (85 aa), FASTA scores: opt:
224, E(): 1.8e-09, (46.45% identity in 84 aa overlap);
etc. Equivalent to AAK47292 from Mycobacterium
tuberculosis strain CDC1551 (141 aa) but shorter 13 aa. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2898c"
/db_xref="EnsemblGenomes-Tr:CCP45700"
/db_xref="GOA:P9WFM9"
/db_xref="InterPro:IPR003509"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR011856"
/db_xref="UniProtKB/Swiss-Prot:P9WFM9"
/protein_id="CCP45700.1"
/translation="MTTLKTMTRVQLGAMGEALAVDYLTSMGLRILNRNWRCRYGELD
VIACDAATRTVVFVEVKTRTGDGYGGLAHAVTERKVRRLRRLAGLWLADQEERWAAVR
IDVIGVRVGPKNSGRTPELTHLQGIG"
gene complement(3208576..3209406)
/gene="fdhD"
/locus_tag="Rv2899c"
CDS complement(3208576..3209406)
/codon_start=1
/transl_table=11
/gene="fdhD"
/locus_tag="Rv2899c"
/product="Possible FdhD protein homolog"
/note="Rv2899c, (MTCY274.30c), len: 276 aa. Possible fdhD
protein homolog, highly similar to other bacterial fdhd
protein homologs or formate dehydrogenase accessory
proteins e.g. Q9ZBW0|FDHD_STRCO|SC4B5.08c from
Streptomyces coelicolor (282 aa), FASTA scores: opt: 1032,
E(): 3.6e-59,(59.0% identity in 278 aa overlap);
BAB59387|TVG0258796 from Thermoplasma volcanium (279 aa),
FASTA scores: opt: 536, E(): 3.4e-27, (38.65% identity in
282 aa overlap); Q9HL17|FDHD_THEAC|TA0423 from
Thermoplasma acidophilum (282 aa), FASTA scores: opt: 529,
E(): 9.6e-27, (38.8% identity in 281 aa overlap);
P32177|FDHD_ECOLI FDHD protein from Escherichia coli
strain K12 (277 aa), FASTA scores: opt: 297, E(): 8.6e-12,
(33.35% identity in 261 aa overlap); etc. Contain a Pfam
match to entry PF02634 FdhD/NarQ family. Belongs to the
FdhD family."
/db_xref="EnsemblGenomes-Gn:Rv2899c"
/db_xref="EnsemblGenomes-Tr:CCP45701"
/db_xref="GOA:P9WNF1"
/db_xref="InterPro:IPR003786"
/db_xref="InterPro:IPR016193"
/db_xref="UniProtKB/Swiss-Prot:P9WNF1"
/protein_id="CCP45701.1"
/translation="MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTM
RTPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVK
PPDVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQ
KVFARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSG
RASFELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT
"
gene complement(3209406..3211745)
/gene="fdhF"
/locus_tag="Rv2900c"
CDS complement(3209406..3211745)
/codon_start=1
/transl_table=11
/gene="fdhF"
/locus_tag="Rv2900c"
/product="Possible formate dehydrogenase H FdhF
(formate-hydrogen-lyase-linked, selenocysteine-containing
polypeptide) (formate dehydrogenase-H alpha subunit)
(FDH-H)"
/note="Rv2900c, (MTCY274.31c), len: 779 aa. Possible
fdhF,formate dehydrogenase, highly similar to others
formate dehydrogenases and prokaryotic
molybdopterin-containing oxidoreductases e.g.
Q9S2J9|SC7H2.18 putative formate dehydrogenase from
Streptomyces coelicolor (759 aa), FASTA scores: opt: 3038,
E(): 2.7e-180, (59.7% identity in 767 aa overlap);
Q9HU08|PA5181 probable oxidoreductase from Pseudomonas
aeruginosa (773 aa), FASTA scores: opt: 2560,E():
1.1e-150, (53.2% identity in 761 aa overlap); P78160
formate dehydrogenase a chain (fragment) from Escherichia
coli strain K12 (740 aa), FASTA scores: opt: 2002, E():
3.7e-116, (43.1% identity in 733 aa overlap);
P07658|FDHF_ECOLI|P78137|B4079 formate dehydrogenase from
Escherichia coli strain K12 (715 aa), FASTA scores: opt:
305, E(): 5.6e-13, (25.5% identity in 748 aa overlap);
etc. Belongs to the prokaryotic molybdopterin-containing
oxidoreductase family."
/db_xref="EnsemblGenomes-Gn:Rv2900c"
/db_xref="EnsemblGenomes-Tr:CCP45702"
/db_xref="GOA:P9WJP9"
/db_xref="InterPro:IPR006656"
/db_xref="InterPro:IPR006657"
/db_xref="InterPro:IPR009010"
/db_xref="InterPro:IPR010046"
/db_xref="InterPro:IPR037951"
/db_xref="InterPro:IPR041953"
/db_xref="UniProtKB/Swiss-Prot:P9WJP9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45702.1"
/translation="MYVEAVRWQRSAASRDVLADYDEQAVTVAPRKREAAGVRAVMVS
LQRGMQQMGALRTAAALARLNQRNGFDCPGCAWPEEPGGRKLAEFCENGAKAVAEEAT
KRTVTAEFFARHSVAELSAKPEYWLSQQGRLAHPMVLRPGDDHYRPISWDAAYQLIAE
QLNGLDSPDRAVFYTSGRTSNEAAFCYQLLVRSFGTNNLPDCSNMCHESSGAALTDSI
GIGKGSVTIGDVEHADLIVIAGQNPGTNHPRMLSVLGKAKANGAKIIAVNPLPEAGLI
RFKDPQKVNGVVGHGIPIADEFVQIRLGGDMALFAGLGRLLLEAEERVPGSVVDRSFV
DNHCAGFDGYRRRTLQVGLDTVMDATGIELAQLQRVAAMLMASQRTVICWAMGLTQHA
HAVATIGEVTNVLLLRGMIGKPGAGVCPVRGHSNVQGDRTMGIWEKMPEQFLAALDRE
FGITSPRAHGFDTVAAIRAMRDGRVSVFMGMGGNFASATPDTAVTEAALRRCALTVQV
STKLNRSHLVHGATALILPTLGRTDRDTRNGRKQLVSVEDSMSMVHLSRGSLHPPSDQ
VRSEVQIICQLARALFGPGHPVPWERFADDYDTIRDAIAAVVPGCDDYNHKVRVPDGF
QLPHPPRDAREFRTSTGKANFAVNPLQWVPVPPGRLVLQTLRSHDQYNTTIYGLDDRY
RGVKGGRRVVFINPADIETFGLTAGDRVDLVSEWTDGQGGLQERRAKDFLVVAYSTPV
GNAAAYYPETNPLVPLDHTAAQSNTPVSKAIIVRLEPTA"
gene complement(3211803..3212108)
/locus_tag="Rv2901c"
CDS complement(3211803..3212108)
/codon_start=1
/transl_table=11
/locus_tag="Rv2901c"
/product="Conserved protein"
/note="Rv2901c, (MTCY274.32c), len: 101 aa. Conserved
protein, very equivalent to O33023|ML1610|MLCB250.41
hypothetical 12.3 KDA protein from Mycobacterium leprae
(101 aa), FASTA scores: opt: 658, E(): 2.6e-43, (99.0%
identity in 101 aa overlap). Also highly similar to
O69889|SC2E1.18 hypothetical protein from Streptomyces
coelicolor and Streptomyces lividans (102 aa), FASTA
scores: opt: 515, E(): 2.2e-32, (75.0% identity in 100 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2901c"
/db_xref="EnsemblGenomes-Tr:CCP45703"
/db_xref="GOA:P9WL27"
/db_xref="InterPro:IPR019592"
/db_xref="UniProtKB/Swiss-Prot:P9WL27"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45703.1"
/translation="MSAEDLEKYETEMELSLYREYKDIVGQFSYVVETERRFYLANSV
EMVPRNTDGEVYFELRLADAWVWDMYRPARFVKQVRVVTFKDVNIEEVEKPELRLPE"
gene complement(3212162..3212956)
/gene="rnhB"
/locus_tag="Rv2902c"
CDS complement(3212162..3212956)
/codon_start=1
/transl_table=11
/gene="rnhB"
/locus_tag="Rv2902c"
/product="Probable ribonuclease HII protein RnhB (RNase
HII)"
/note="Rv2902c, (MT2970, MTCY274.33c), len: 264 aa.
Probable rnhB, ribonuclease HII, equivalent to
O33022|RNH2_MYCLE|RNHB|ML1611|MLCB250.40 ribonuclease HII
from Mycobacterium leprae (240 aa), FASTA scores: opt:
1242, E(): 6.9e-72, (76.75% identity in 245 aa overlap).
Also similar (but longer ~20 aa) to others e.g.
Q9HXY9|RNHB|PA3642 ribonuclease HII from Pseudomonas
aeruginosa (201 aa), FASTA scores: opt: 572, E():
3.1e-29,(52.7% identity in 184 aa overlap);
Q9PEI7|RNH2_XYLFA|RNHB|XF1041 ribonuclease HII from
Xylella fastidiosa (234 aa), FASTA scores: opt: 556, E():
3.6e-28,(50.25% identity in 185 aa overlap);
P10442|RNH2_ECOLI|RNHB|B0183 ribonuclease HII from
Escherichia coli strain K-12 (213 aa), FASTA scores: opt:
519, E(): 7.4e-26, (48.65% identity in 183 aa overlap);
etc. Belongs to the RNASE HII family. Cofactor: manganese
(by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv2902c"
/db_xref="EnsemblGenomes-Tr:CCP45704"
/db_xref="GOA:P9WH01"
/db_xref="InterPro:IPR001352"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR022898"
/db_xref="InterPro:IPR024567"
/db_xref="InterPro:IPR036397"
/db_xref="UniProtKB/Swiss-Prot:P9WH01"
/protein_id="CCP45704.1"
/translation="MTKTWPPRTVIRKSGGLRGMRTLESALHRGGLGPVAGVDEVGRG
ACAGPLVVAACVLGPGRIASLAALDDSKKLSEQAREKLFPLICRYAVAYHVVFIPSAE
VDRRGVHVANIEGMRRAVAGLAVRPGYVLSDGFRVPGLPMPSLPVIGGDAAAACIAAA
SVLAKVSRDRVMVALDADHPGYGFAEHKGYSTPAHSRALARLGPCPQHRYSFINVRRV
ASGSNTAEVADGQPDPRDGTAQTGEGRWSKSSHPATMRATGRAQGT"
gene complement(3212970..3213854)
/gene="lepB"
/locus_tag="Rv2903c"
CDS complement(3212970..3213854)
/codon_start=1
/transl_table=11
/gene="lepB"
/locus_tag="Rv2903c"
/product="Probable signal peptidase I LepB (SPASE I)
(leader peptidase I)."
/note="Rv2903c, (MTCY274.34c), len: 294 aa. Probable
lepB,signal peptidase I (type II membrane protein) (see
Braunstein & Belisle 2000), equivalent to
O33021|LEP_MYCLE|ML1612|MLCB250.39 probable signal
peptidase I from Mycobacterium leprae (289 aa), FASTA
scores: opt: 1335, E(): 1.8e-77, (69.75% identity in 301
aa overlap). Also similar to many e.g. O86869|SIPX signal
peptidase I from Streptomyces lividans (320 aa), FASTA
scores: opt: 474, E(): 1e-22, (43.55% identity in 248 aa
overlap); O69884|SIP1|SIPW putative signal peptidase I
from Streptomyces coelicolor and Streptomyces lividans
(259 aa),FASTA scores: opt: 226, E(): 5e-07, (36.0%
identity in 214 aa overlap); P42668|LEP_BACLI|sip signal
peptidase I from Bacillus licheniformis (186 aa), FASTA
scores: opt: 218,E(): 1.3e-06, (34.5% identity in 194 aa
overlap); etc. Contains PS00501 Signal peptidases I serine
active site,and PS00761 Signal peptidases I signature 3.
Belongs to peptidase family S26; also known as type I
leader peptidase family. Conserved in M. tuberculosis, M.
leprae, M. bovis and M. avium paratuberculosis; predicted
to be essential for in vivo survival and pathogenicity
(See Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2903c"
/db_xref="EnsemblGenomes-Tr:CCP45705"
/db_xref="GOA:P9WKA1"
/db_xref="InterPro:IPR000223"
/db_xref="InterPro:IPR015927"
/db_xref="InterPro:IPR019533"
/db_xref="InterPro:IPR019756"
/db_xref="InterPro:IPR019758"
/db_xref="InterPro:IPR036286"
/db_xref="UniProtKB/Swiss-Prot:P9WKA1"
/inference="protein motif:PROSITE:PS00761"
/inference="protein motif:PROSITE:PS00501"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45705.1"
/translation="MTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDAD
SEGDSKAAKTDEPRPAKRSTLREFAVLAVIAVVLYYVMLTFVARPYLIPSESMEPTLH
GCSTCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALS
FIGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPC
LGSEFGPVTVPPGRVWVMGDNRTHSADSRAHCPLLCTDDPLPGTVPVANVIGKARLIV
WPPSRWGVVRSVNPQQGR"
gene complement(3213912..3214253)
/gene="rplS"
/locus_tag="Rv2904c"
CDS complement(3213912..3214253)
/codon_start=1
/transl_table=11
/gene="rplS"
/locus_tag="Rv2904c"
/product="50S ribosomal protein L19 RplS"
/note="Rv2904c, (MTCY274.35c), len: 113 aa. rplS, 50S
ribosomal protein L19, equivalent to O33020|RL19_MYCLE 50S
ribosomal protein L19 from Mycobacterium leprae (113
aa),FASTA scores: opt: 702, E(): 1.4e-45, (93.8% identity
in 113 aa overlap). Also highly similar to others e.g.
O69883|RL19_STRCO from Streptomyces coelicolor (116
aa),FASTA scores: opt: 571, E(): 9.5e-36, (77.25% identity
in 110 aa overlap); O31742|RL19_BACSU from Bacillus
subtilis (115 aa), FASTA scores: opt: 523, E(): 3.8e-32,
(72.9% identity in 107 aa overlap); RL19_BACST|P30529 from
Bacillus stearothermophilus (116 aa), FASTA scores: opt:
518, E(): 9.1e-32, (71.7% identity in 106 aa overlap);
etc. Belongs to the L19P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv2904c"
/db_xref="EnsemblGenomes-Tr:CCP45706"
/db_xref="GOA:P9WHC9"
/db_xref="InterPro:IPR001857"
/db_xref="InterPro:IPR008991"
/db_xref="InterPro:IPR018257"
/db_xref="InterPro:IPR038657"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHC9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45706.1"
/translation="MNRLDFVDKPSLRDDIPAFNPGDTINVHVKVIEGAKERLQVFKG
VVIRRQGGGIRETFTVRKESYGVGVERTFPVHSPNIDHIEVVTRGDVRRAKLYYLREL
RGKKAKIKEKR"
gene 3214628..3215572
/gene="lppW"
/locus_tag="Rv2905"
CDS 3214628..3215572
/codon_start=1
/transl_table=11
/gene="lppW"
/locus_tag="Rv2905"
/product="Probable conserved alanine rich lipoprotein
LppW"
/note="Rv2905, (MTCY274.36), len: 314 aa. Probable
lppW,conserved ala-rich lipoprotein, with slight
similarity to beta-lactamases and hypothetical proteins
e.g. Q9S1P7|SCJ9A.23 hypothetical 36.3 KDA protein from
Streptomyces coelicolor (336 aa), FASTA scores: opt:
222,E(): 2.8e-06, (25.5% identity in 298 aa overlap);
O69914|SC3C8.01 putative secreted protein from
Streptomyces coelicolor (302 aa), FASTA scores: opt: 201,
E(): 5.1e-05,(24.9% identity in 257 aa overlap);
P14559|BLAC_STRAL beta-lactamase precursor from
Streptomyces albus G (314 aa), FASTA scores: opt: 113,
E(): 3.3, (25.2% identity in 278 aa overlap); etc. Has
signal peptide and appropriately positioned prokaryotic
lipoprotein lipid attachment site: attached to the
membrane by a lipid anchor (potential)."
/db_xref="EnsemblGenomes-Gn:Rv2905"
/db_xref="EnsemblGenomes-Tr:CCP45707"
/db_xref="GOA:P9WK67"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/Swiss-Prot:P9WK67"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45707.1"
/translation="MRARPLTLLTALAAVTLVVVAGCEARVEAEAYSAADRISSRPQA
RPQPQPVELLLRAITPPRAPAASPNVGFGELPTRVRQATDEAAAMGATLSVAVLDRAT
GQLVSNGNTQIIATASVAKLFIADDLLLAEAEGKVTLSPEDHHALDVMLQSSDDGAAE
RFWSQDGGNAVVTQVARRYGLRSTAPPSDGRWWNTISSAPDLIRYYDMLLDGSGGLPL
DRAAVIIADLAQSTPTGIDGYPQRFGIPDGLYAEPVAVKQGWMCCIGSSWMHLSTGVI
GPERRYIMVIESLQPADDATARATITQAVRTMFPNGRI"
gene complement(3215665..3216357)
/gene="trmD"
/locus_tag="Rv2906c"
CDS complement(3215665..3216357)
/codon_start=1
/transl_table=11
/gene="trmD"
/locus_tag="Rv2906c"
/product="Probable tRNA (guanine-N1)-methyltransferase
TrmD (M1G-methyltransferase) (tRNA [GM37]
methyltransferase)"
/note="Rv2906c, (MTCY274.37c), len: 230 aa. Probable
trmD,tRNA m1G methyltransferase, equivalent to
O33017|TRMD_MYCLE from Mycobacterium leprae (238 aa),
FASTA scores: opt: 1363, E(): 8.1e-86, (87.2% identity in
227 aa overlap). Also highly similar to others e.g.
O69882|TRMD_STRCO from Streptomyces coelicolor and S.
lividans (277 aa), FASTA scores: opt: 841, E(): 4.5e-50,
(55.55% identity in 234 aa overlap); Q9A0B6 from
Streptococcus pyogenes (243 aa),FASTA scores: opt: 698,
E(): 2.5e-40, (47.6% identity in 227 aa overlap);
P07020|TRMD_ECOLI|TRMD|B2607|Z3901|ECS3470 from
Escherichia coli strain O157:H7 (255 aa), FASTA scores:
opt: 573, E(): 3.8e-33, (42.1% identity in 228 aa
overlap); etc. Belongs to the RNA methyltransferase TRMD
family."
/db_xref="EnsemblGenomes-Gn:Rv2906c"
/db_xref="EnsemblGenomes-Tr:CCP45708"
/db_xref="GOA:P9WFY7"
/db_xref="InterPro:IPR002649"
/db_xref="InterPro:IPR016009"
/db_xref="InterPro:IPR023148"
/db_xref="InterPro:IPR029026"
/db_xref="InterPro:IPR029028"
/db_xref="PDB:5ZHJ"
/db_xref="PDB:5ZHK"
/db_xref="PDB:5ZHL"
/db_xref="UniProtKB/Swiss-Prot:P9WFY7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45708.1"
/translation="MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDV
HHSVDDAPYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTTES
HLVFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAGVL
GNPASHQDDSHSTGLDGLLEGPSYTRPASWRGLDVPEVLLSGDHARIAAWRREVSLQR
TRERRPDLSHPD"
gene complement(3216361..3216891)
/gene="rimM"
/locus_tag="Rv2907c"
CDS complement(3216361..3216891)
/codon_start=1
/transl_table=11
/gene="rimM"
/locus_tag="Rv2907c"
/product="Probable 16S rRNA processing protein RimM"
/note="Rv2907c, (MTCY274.38c), len: 176 aa. Probable
rimM,16S rRNA processing protein, equivalent to
O33016|RIMM_MYCLE probable 16S rRNA processing protein
from Mycobacterium leprae (179 aa), FASTA scores: opt:
797, E(): 2.4e-46, (73.15% identity in 175 aa overlap).
Also highly similar to others e.g. O69881|RIMM_STRCO from
Streptomyces coelicolor (188 aa), FASTA scores: opt: 485,
E(): 2.3e-25,(48.85% identity in 176 aa overlap);
Q9KA14|RIMM_BACHD from Bacillus halodurans (173 aa), FASTA
scores: opt: 289, E(): 3.2e-12, (30.65% identity in 173 aa
overlap); P21504|RIMM_ECOLI|RIMM|B2608 from Escherichia
coli strain K12 (182 aa), FASTA scores: opt: 237, E():
1e-08, (29.4% identity in 177 aa overlap). Belongs to the
RimM family."
/db_xref="EnsemblGenomes-Gn:Rv2907c"
/db_xref="EnsemblGenomes-Tr:CCP45709"
/db_xref="GOA:P9WH19"
/db_xref="InterPro:IPR002676"
/db_xref="InterPro:IPR009000"
/db_xref="InterPro:IPR011033"
/db_xref="InterPro:IPR011961"
/db_xref="InterPro:IPR027275"
/db_xref="InterPro:IPR036976"
/db_xref="UniProtKB/Swiss-Prot:P9WH19"
/protein_id="CCP45709.1"
/translation="MELVVGRVVKSHGVTGEVVVEIRTDDPADRFAPGTRLRAKGPFD
GGAEGSAVSYVIESVRQHGGRLLVRLAGVADRDAADALRGSLFVIDADDLPPIDEPDT
YYDHQLVGLMVQTATGEGVGVVTEVVHTAAGELLAVKRDSDEVLVPFVRAIVTSVSLD
DGIVEIDPPHGLLNLE"
gene complement(3216905..3217147)
/locus_tag="Rv2908c"
CDS complement(3216905..3217147)
/codon_start=1
/transl_table=11
/locus_tag="Rv2908c"
/product="Conserved hypothetical protein"
/note="Rv2908c, (MTCY274.40c), len: 80 aa. Conserved
hypothetical protein, equivalent to O33015|YT08_MYCLE from
Mycobacterium leprae (80 aa), FASTA scores: opt: 492, E():
3.1e-29, (93.75% identity in 80 aa overlap). Also highly
similar to others e.g. O69880|YE09_STRCO from Streptomyces
coelicolor (79 aa), FASTA scores: opt: 356, E():
3e-19,(71.6% identity in 74 aa overlap); Q9KA12|BH2482
protein from Bacillus halodurans (76 aa), FASTA scores:
opt: 220,E(): 2.9e-09, (48.6% identity in 72 aa overlap);
O31738|YLQC_BACSU hypothetical 9.1 KDA protein from
Bacillus subtilis (81 aa), FASTA scores: opt: 172, E():
1e-05, (39.2% identity in 74 aa overlap); etc. Belongs to
the UPF0109 family."
/db_xref="EnsemblGenomes-Gn:Rv2908c"
/db_xref="EnsemblGenomes-Tr:CCP45710"
/db_xref="GOA:P9WFM7"
/db_xref="InterPro:IPR009019"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR020627"
/db_xref="UniProtKB/Swiss-Prot:P9WFM7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45710.1"
/translation="MSAVVVDAVEHLVRGIVDNPDDVRVDLITSRRGRTVEVHVHPDD
LGKVIGRGGRTATALRTLVAGIGGRGIRVDVVDTDQ"
gene complement(3217155..3217643)
/gene="rpsP"
/locus_tag="Rv2909c"
CDS complement(3217155..3217643)
/codon_start=1
/transl_table=11
/gene="rpsP"
/locus_tag="Rv2909c"
/product="30S ribosomal protein S16 RpsP"
/note="Rv2909c, (MTCY274.41c), len: 162 aa. rpsP, 30S
ribosomal protein S16, equivalent to O33014|RS16_MYCLE 30S
ribosomal protein S16 from Mycobacterium leprae (160
aa),FASTA scores: opt: 828, E(): 1.6e-39, (82.5% identity
in 160 aa overlap). Also highly similar to others e.g.
O69879|RS16_STRCO 30S ribosomal protein S16 from
Streptomyces coelicolor (139 aa), FASTA scores: opt:
486,E(): 1.9e-20, (56.95% identity in 144 aa overlap);
P80379|RS16_THETH 30S ribosomal protein S16 from Thermus
Thermophilus (88 aa), FASTA scores: opt: 280, E():
4.8e-09,(53.25% identity in 77 aa overlap) (C-terminus
shorter); P21474|RS16_BACSU|RPSP 30S ribosomal protein S16
(BS17) from Bacillus subtilis (89 aa,), FASTA scores: opt:
258,E(): 8.2e-08, (42.85% identity in 91 aa overlap)
(C-terminus shorter); etc. Belongs to the S16P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv2909c"
/db_xref="EnsemblGenomes-Tr:CCP45711"
/db_xref="GOA:P9WH53"
/db_xref="InterPro:IPR000307"
/db_xref="InterPro:IPR020592"
/db_xref="InterPro:IPR023803"
/db_xref="UniProtKB/Swiss-Prot:P9WH53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45711.1"
/translation="MAVKIKLTRLGKIRNPQYRVAVADARTRRDGRAIEVIGRYHPKE
EPSLIEINSERAQYWLSVGAQPTEPVLKLLKITGDWQKFKGLPGAQGRLKVAAPKPSK
LEVFNAALAAADGGPTTEATKPKKKSPAKKAAKAAEPAPQPEQPDTPALGGEQAELTA
ES"
gene complement(3217827..3218270)
/locus_tag="Rv2910c"
CDS complement(3217827..3218270)
/codon_start=1
/transl_table=11
/locus_tag="Rv2910c"
/product="Conserved hypothetical protein"
/note="Rv2910c, (MTCY274.42c), len: 147 aa. Conserved
hypothetical protein, showing some similarity with
hypothetical proteins from other organisms e.g.
Q9JN76|MMYY hypothetical 17.4 KDA protein from
Streptomyces coelicolor (153 aa), FASTA scores: opt: 164,
E(): 0.00026, (35.05% identity in 129 aa overlap); etc.
Also some similarity with protein from Mycobacterium
tuberculosis e.g. O07237|Rv0310c|MTCY63.15c (163 aa),
FASTA scores: opt: 165,E(): 0.00023, (26.3% identity in
137 aa overlap); P96815|Rv0138|MTCI5.12 (167 aa), FASTA
scores: opt: 132,E(): 0.048, (30.25% identity in 109 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2910c"
/db_xref="EnsemblGenomes-Tr:CCP45712"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/Swiss-Prot:P9WL25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45712.1"
/translation="MCAVLDRSMLSVAEISDRLEIQQLLVDYSSAIDQRRFDDLDRVF
TPDAYIDYRALGGIDGRYPKIKQWLSQVLGNFPVYAHMLGNFSVRVDGDTASSRVICF
NPMVFAGDRQQVLFCGLWYDDDFVRTPDGWRIIRRVETKCFQKMM"
gene 3218339..3219214
/gene="dacB2"
/gene_synonym="dacB"
/locus_tag="Rv2911"
CDS 3218339..3219214
/codon_start=1
/transl_table=11
/gene="dacB2"
/gene_synonym="dacB"
/locus_tag="Rv2911"
/product="Probable penicillin-binding protein DacB2
(D-alanyl-D-alanine carboxypeptidase) (DD-peptidase)
(DD-carboxypeptidase) (PBP) (DD-transpeptidase)
(serine-type D-ala-D-ala carboxypeptidase) (D-amino acid
hydrolase)"
/note="Rv2911, (MTCY274.43), len: 291 aa. Probable
dacB2,D-alanyl-D-alanine carboxypeptidase
(penicillin-binding protein), an ala-rich protein. Highly
similar (except in N-terminus) to Q9CCM2|ML0691 putative
D-alanyl-D-alanine carboxypeptidase from Mycobacterium
leprae (411 aa), FASTA scores: opt: 749, E(): 9.3e-39,
(46.75% identity in 276 aa overlap). Also similar to
penicillin binding proteins / D-alanyl-D-alanine
carboxypeptidases e.g. Q9KCJ8|SC4G1.16c D-alanyl-D-alanine
carboxypeptidase from Streptomyces coelicolor (382 aa),
FASTA scores: opt: 386, E(): 2.1e-16,(31.25% identity in
285 aa overlap); P35150|DACB_BACSU penicillin-binding
protein 5* precursor from Bacillus subtilis (382 aa),
FASTA scores: opt: 384, E(): 3.6e-17,(30.7% identity in
244 aa overlap); Q9K8X5|DACB|BH2877 D-alanyl-D-alanine
carboxypeptidase (penicillin-binding protein 5) from
Bacillus halodurans (395 aa), FASTA scores: opt: 359, E():
9.7e-15, (30.3% identity in 241 aa overlap);
P33364|PBP7_ECOLI|PBPG|B2134 penicillin-binding protein 7
precursor from Escherichia coli strain K12 (313 aa), FASTA
scores: opt: 273, E(): 7.5e-10, (27.8% identity in 263 aa
overlap); etc. Also similar to O53380|Rv3330|MTV016.30
penicillin-binding protein from Mycobacterium tuberculosis
(405 aa), FASTA scores: opt: 746, E(): 1.4e-38, (47.0%
identity in 266 aa overlap). Seems to contain PF00768
Peptidase_S11 domain PFAM. Belongs to peptidase family
S11; also known as the D-alanyl-D-alanine carboxypeptidase
1 family. Thought to be a membrane-bound protein. Note
that previously known as dacB."
/db_xref="EnsemblGenomes-Gn:Rv2911"
/db_xref="EnsemblGenomes-Tr:CCP45713"
/db_xref="GOA:I6Y204"
/db_xref="InterPro:IPR001967"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR018044"
/db_xref="PDB:4RYE"
/db_xref="UniProtKB/TrEMBL:I6Y204"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45713.1"
/translation="MRKLMTATAALCACAVTVSAGAAWADADVQPAGSVPIPDGPAQT
WIVADLDSGQVLAGRDQNVAHPPASTIKVLLALVALDELDLNSTVVADVADTQAECNC
VGVKPGRSYTARQLLDGLLLVSGNDAANTLAHMLGGQDVTVAKMNAKAATLGATSTHA
TTPSGLDGPGGSGASTAHDLVVIFRAAMANPVFAQITAEPSAMFPSDNGEQLIVNQDE
LLQRYPGAIGGKTGYTNAARKTFVGAAARGGRRLVIAMMYGLVKEGGPTYWDQAATLF
DWGFALNPQASVGSL"
gene complement(3219274..3219861)
/locus_tag="Rv2912c"
CDS complement(3219274..3219861)
/codon_start=1
/transl_table=11
/locus_tag="Rv2912c"
/product="Probable transcriptional regulatory protein
(probably TetR-family)"
/note="Rv2912c, (MTCY274.44c), len: 195 aa. Probable
transcription regulatory protein, TetR family, showing
similarity with others e.g. Q9K3V9|SCD10.17 putative
TetR-family transcriptional from Streptomyces coelicolor
(202 aa), FASTA scores: opt: 185, E(): 4.4e-05, (31.15%
identity in 167 aa overlap); Q9KFQ0 TetR-family from
Bacillus halodurans (185 aa), FASTA scores: opt: 164, E():
0.001, (35.6% identity in 73 aa overlap);
P17446|BETI_ECOLI|BETI|B0313 regulatory protein from
Escherichia coli strain K12 (195 aa), FASTA scores: opt:
126, E(): 0.024, (24.5% identity in 196 aa overlap); etc.
Contains possible helix-turn-helix motif at aa 33-54
(+2.71 SD). Possibly belongs to the TetR/AcrR family."
/db_xref="EnsemblGenomes-Gn:Rv2912c"
/db_xref="EnsemblGenomes-Tr:CCP45714"
/db_xref="GOA:P9WMC7"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="UniProtKB/Swiss-Prot:P9WMC7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45714.1"
/translation="MARTQQQRREETVARLLQASIDTIIEVGYARASAAVITKRAGVS
VGALFRHFETMGDFMAATAYEVLRRQLETFTKQVAEIPADRPALPAALTILRDITAGS
TNAVLYELMVAARTDEKLKETLQNVLGQYSAKIHDAARALPGAESFPEETFPVIVALM
TNVFDGAAIVRGVLPQPELEEQRIPMLTALLTAGL"
gene complement(3219863..3221698)
/locus_tag="Rv2913c"
CDS complement(3219863..3221698)
/codon_start=1
/transl_table=11
/locus_tag="Rv2913c"
/product="Possible D-amino acid aminohydrolase (D-amino
acid hydrolase)"
/note="Rv2913c, (MTCY338.01c, MTCY274.45c), len: 611 aa.
Possible D-amino acid aminohydrolase, similar (principally
in N-terminus) to D-amino acid aminohydrolases e.g.
Q9V2D3|NDAD|PAB0090 D-aminoacylase (aspartate, glutamate
etc) from Pyrococcus abyssi (526 aa), FASTA scores: opt:
336, E(): 2.2e-13, (27.55% identity in 581 aa overlap);
P94212|NDDD_ALCXX N-acyl-D-aspartate deacylase
(N-acyl-D-aspartate amidohydrolase) from Alcaligenes
xylosoxydans xylosoxydans (Achromobacter xylosoxidans)
(498 aa), FASTA scores: opt: 221, E(): 3.4e-06, (25.95%
identity in 532 aa overlap); Q9AGH8 D-aminoacylase from
Alcaligenes faecalis (484 aa), FASTA scores: opt: 218,
E(): 5.1e-06,(28.35% identity in 434 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2913c"
/db_xref="EnsemblGenomes-Tr:CCP45715"
/db_xref="GOA:P9WJH9"
/db_xref="InterPro:IPR011059"
/db_xref="InterPro:IPR013108"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/Swiss-Prot:P9WJH9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45715.1"
/translation="MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGV
VATVAAGALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTTVL
LGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQTWSTPAEYIEAIDALPLGP
NVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMAKLLDEALEAGMLGMSGMDAAI
DKLDGDRFRSRALPSTFATWRERRKLISVLRHRGRILQSAPDVDNPVSALLFFLASSR
IFNRRKGVRMSMLVSADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDG
IDLPVFEEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHDA
VIVECPDKSLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWTTIVANHRPNQLNK
LAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDADRAGQPFLSIERAVYRLTGEL
AEWFGIGAGTLRQGDRADFAVIDPTHLDESVDGYHEEAVPYYGGLRRMVNRNDATVVA
TGVGGTVVFRGGQFGGQFRDGYGQNVKSGRYLRAGELGAALSRSA"
gene complement(3221767..3223524)
/gene="pknI"
/locus_tag="Rv2914c"
CDS complement(3221767..3223524)
/codon_start=1
/transl_table=11
/gene="pknI"
/locus_tag="Rv2914c"
/product="Probable transmembrane serine/threonine-protein
kinase I PknI (protein kinase I) (STPK I) (phosphorylase B
kinase kinase) (hydroxyalkyl-protein kinase)"
/note="Rv2914c, (MTCY338.02c), len: 585 aa. Probable
pknI,transmembrane serine/threonine-protein kinase (see
citation below), ala-rich protein, highly similar to many
in Mycobacterium tuberculosis and other bacteria e.g.
Q9RLQ7|MBK putative serine/threonine protein kinase from
Mycobacterium bovis BCG (291 aa), FASTA scores: opt:
376,E(): 1.1e-10, (36.95% identity in 287 aa overlap);
P33973|PKN1_MYXXA serine/threonine-protein kinase from
Myxococcus xanthus (693 aa), FASTA scores: opt: 286, E():
5.4e-10, (29.9% identity in 374 aa overlap);
P72003|PKNF_MYCTU|Rv1746|MT1788|MTCY28.09 probable
serine/threonine-protein kinase from Mycobacterium
tuberculosis (476 aa), FASTA scores: opt: 675, E():
1.7e-24, (39.75% identity in 468 aa overlap);
Q10697|PKNJ_MYCTU|Rv2088|MT2149|MTCY49.28 probable
serine/threonine-protein kinase from Mycobacterium
tuberculosis (589 aa), FASTA scores: opt: 574, E():
1e-19,(34.85% identity in 479 aa overlap); etc. Equivalent
to AAK47308 from Mycobacterium tuberculosis strain CDC1551
(603 aa) but shorter 18 aa. Contains Hank's kinase
subdomain. Belongs to the Ser/Thr family of protein
kinases."
/db_xref="EnsemblGenomes-Gn:Rv2914c"
/db_xref="EnsemblGenomes-Tr:CCP45716"
/db_xref="GOA:P9WI69"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR011009"
/db_xref="PDB:5M06"
/db_xref="PDB:5M07"
/db_xref="PDB:5M08"
/db_xref="PDB:5M09"
/db_xref="PDB:5XKA"
/db_xref="PDB:5XLL"
/db_xref="PDB:5XLM"
/db_xref="UniProtKB/Swiss-Prot:P9WI69"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45716.1"
/translation="MALASGVTFAGYTVVRMLGCSAMGEVYLVQHPGFPGWQALKVLS
PAMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMA
DRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADF
GIASQPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAF
RPDLARLDGVLSRALATAPADRFGSCREFADAMNEQAGVAIADQSSGGVDASEVTAAA
GEEAYVVDYPAYGWPEAVDCKEPSARAPAPAAPTPQRRGSMLQSAAGVLARRLDNFST
ATKAPASPTRRRPRRILVGAVAVLLLAGLFAVGIVIGRKTNTTATEVARPPTSGSAVP
SAPTTTVAVTAPVPLDGTYRIEIQRSKQTYDYTPTPQPPDVNTWWAFRTSCTPTECLA
AATMLDDNDHTQAKTPPVRPFLMQFGEGQWKSRPETVQFPCVGPNGSPSTQATTQLLA
LRPQPQGDLVGEMVVTVHSNECGQQGAVIRIPAVASRSGDLPPAVTVPDPATIPDTPD
TTSTATLTPPTTTAPGPGR"
gene complement(3223568..3224680)
/locus_tag="Rv2915c"
CDS complement(3223568..3224680)
/codon_start=1
/transl_table=11
/locus_tag="Rv2915c"
/product="Conserved protein"
/note="Rv2915c, (MTCY338.03c), len: 370 aa. Conserved
protein, posssibly XAA-pro dipeptidase (prolidase), highly
similar to CAC38796|SCI39.08c conserved hypothetical
protein from Streptomyces coelicolor (363 aa), FASTA
scores: opt: 1341, E(): 5.5e-76, (56.65% identity in 362
aa overlap); and similar to prolidases (XAA-pro
dipeptidase) e.g. Q9ABC9|CC0300 putative XAA-pro
dipeptidase from Caulobacter crescentus (428 aa), FASTA
scores: opt: 327,E(): 7.4e-13, (30.2% identity in 374 aa
overlap); Q97XD4 prolidase from Sulfolobus solfataricus
(396 aa), FASTA scores: opt: 271, E(): 2.1e-09, (30.5%
identity in 354 aa overlap); Q9WX55 prolidase from
Microbacterium esteraromaticum (393 aa), FASTA scores:
opt: 256, E(): 1.8e-08, (27.95% identity in 365 aa
overlap); etc. Also similar to O53619|Rv0074|MTV030.18
conserved hypothetical protein from Mycobacterium
tuberculosis (411 aa), FASTA scores: opt: 243, E():
1.2e-07, (27.5% identity in 389 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2915c"
/db_xref="EnsemblGenomes-Tr:CCP45717"
/db_xref="GOA:P9WL23"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/Swiss-Prot:P9WL23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45717.1"
/translation="MKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVA
GADTVFDGGWILPGLVDAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTD
TRGLDDHEDLPRIIRAGRHLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLV
GDWIDRQIGDLAPLWSDDVLKAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHG
TGLTDDTIALMLEHGTALVPTLINLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAA
AREAGVPVYAGTDAGSTIEHGRIADEVAALQRIGMTAHEALGAACWDARRWLGRPGLD
DRASADLLCYAQDPRQGPGVLQHPDLVILRGRTFGP"
gene complement(3224708..3226285)
/gene="ffh"
/locus_tag="Rv2916c"
CDS complement(3224708..3226285)
/codon_start=1
/transl_table=11
/gene="ffh"
/locus_tag="Rv2916c"
/product="Probable signal recognition particle protein Ffh
(fifty-four homolog) (SRP protein)"
/note="Rv2916c, (MTCY338.04c), len: 525 aa. Probable
ffh,signal recognition particle (SRP) protein (ala-,
gly-,leu-rich protein) (see citation below), equivalent to
O33013|SR54_MYCLE signal recognition particle from
Mycobacterium leprae (521 aa), FASTA scores: opt:
2968,E(): 1.6e-145, (87.85% identity in 526 aa overlap).
Also highly similar to others e.g. O69874|FFH from
Streptomyces coelicolor (550 aa), FASTA scores: opt: 2025,
E(): 6e-97,(63.8% identity in 519 aa overlap) (N-terminus
longer 34 aa); P37105|SR54_BACSU from Bacillus subtilis
(446 aa),FASTA scores: opt: 1451, E(): 1.9e-67, (51.5%
identity in 435 aa overlap); BAB57399|FFH from
Staphylococcus aureus subsp. aureus Mu50 (455 aa), FASTA
scores: opt: 1418, E(): 9.4e-66, (48.65% identity in 448
aa overlap); etc. Contains PS00017 ATP/GTP-binding site
motif A (P-loop). Belongs to the SRP family of GTP-binding
proteins. Note that signal recognition particle consists
of a small cytoplasmic RNA (SC-RNA) molecule and protein
FFH. The protein has a two domain structure: the G-domain
binds GTP; the M-domain binds the RNA and also binds the
signal sequence."
/db_xref="EnsemblGenomes-Gn:Rv2916c"
/db_xref="EnsemblGenomes-Tr:CCP45718"
/db_xref="GOA:P9WGD7"
/db_xref="InterPro:IPR000897"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004125"
/db_xref="InterPro:IPR004780"
/db_xref="InterPro:IPR013822"
/db_xref="InterPro:IPR022941"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036891"
/db_xref="InterPro:IPR042101"
/db_xref="UniProtKB/Swiss-Prot:P9WGD7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45718.1"
/translation="MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVS
LPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTV
VMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFA
PHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAI
NPDEVLFVLDAMIGQDAVTTAAAFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPI
LFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGEL
TLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQER
ADPKIINASRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATR
KSKGAKGKSGKKSKKGTRGPTPPKVKSPFGVPGMPGLAGLPGGLPDLSQMPKGLDELP
PGLADFDLSKLKFPGKK"
gene 3226363..3228243
/locus_tag="Rv2917"
CDS 3226363..3228243
/codon_start=1
/transl_table=11
/locus_tag="Rv2917"
/product="Conserved hypothetical alanine and arginine rich
protein"
/note="Rv2917, (MTCY338.05), len: 626 aa. Conserved
hypothetical ala-, arg-rich protein, highly similar (but
longer 34 aa) to O33011|ML1624|MLCB250.18C hypothetical
65.2 KDA protein from Mycobacterium leprae (596 aa), FASTA
scores: opt: 3117, E(): 9e-183, (79.8% identity in 584 aa
overlap). Also highly similar to Q9S2E8|SCE19A.36C
hypothetical 66.2 KDA protein from Streptomyces coelicolor
(598 aa), FASTA scores: opt: 1921, E(): 1.1e-109, (56.08%
identity in 567 aa overlap); and Q9S3Y6|SDRA SDRA protein
from Streptomyces coelicolor (597 aa), FASTA scores: opt:
1896, E(): 3.6e-108, (55.75% identity in 567 aa overlap).
And shows some similarity with others proteins from other
organisms. Equivalent to AAK47311 putative RNA helicase
from Mycobacterium tuberculosis strain CDC1551 (602 aa)
but longer 24 aa. Contains PS00017 ATP/GTP-binding site
motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2917"
/db_xref="EnsemblGenomes-Tr:CCP45719"
/db_xref="GOA:P9WL21"
/db_xref="InterPro:IPR006935"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WL21"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45719.1"
/translation="MRVTRLVDAESTRCDVGPAPKSVAMLHFTAATSRFRLGRERANS
VRSDGGWGVLQPVSATFNPPLRGWQRRALVQYLGTQPRDFLAVATPGSGKTSFALRIA
AELLRYHTVEQVTVVVPTEHLKVQWAHAAAAHGLSLDPKFANSNPQTSPEYHGVMVTY
AQVASHPTLHRVRTEARKTLVVFDEIHHGGDAKTWGDAIREAFGDATRRLALTGTPFR
SDDSPIPFVSYQPDADGVLRSQADHTYGYAEALADGVVRPVVFLAYSGQARWRDSAGE
EYEARLGEPLSAEQTARAWRTALDPEGEWMPAVITAADRRLRQLRAHVPDAGGMIIAS
DRTTARAYARLLTTMTAEEPTVVLSDDPGSSARITEFAQGTSRWLVAVRMVSEGVDVP
RLSVGVYATNASTPLFFAQAIGRFVRSRRPGETASIFVPSVPNLLQLASALEVQRNHV
LGRPHRESAHDPLDGDPATRTQTERGGAERGFTALGADAELDQVIFDGSSFGTATPTG
SDEEADYLGIPGLLDAEQMRALLHRRQDEQLRKRAQLQKGATQPATSGASASVHGQLR
DLRRELHTLVSIAHHRTGKPHGWIHDERRRRCGGPPIAAATRAQIKARIDALRQLNSE
RS"
gene complement(3228254..3230680)
/gene="glnD"
/locus_tag="Rv2918c"
CDS complement(3228254..3230680)
/codon_start=1
/transl_table=11
/gene="glnD"
/locus_tag="Rv2918c"
/product="Probable [protein-PII] uridylyltransferase GlnD
(PII uridylyl-transferase) (uridylyl removing enzyme)
(UTASE)"
/note="Rv2918c, (MTCY338.07c), len: 808 aa. Probable
glnD,uridylyltransferase (ala-rich protein), similar to
other uridylyltransferases e.g. O69873||SC2E1.02 from
Streptomyces coelicolor (835 aa), FASTA scores: opt:
1473,E(): 2.8e-81, (41.03% identity in 858 aa overlap);
P43919|GLND_HAEIN from Haemophilus influenzae (863
aa),FASTA scores: opt: 333, E(): 2.5e-12, (25.4% identity
in 819 aa overlap); P27249|GLND_ECOLI|GLND|B0167 from
Escherichia coli strain K12 (890 aa), FASTA scores: opt:
306, E(): 1.1e-10, (27.75% identity in 858 aa overlap);
etc. Belongs to the GlnD family."
/db_xref="EnsemblGenomes-Gn:Rv2918c"
/db_xref="EnsemblGenomes-Tr:CCP45720"
/db_xref="GOA:P9WN29"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR003607"
/db_xref="InterPro:IPR006674"
/db_xref="InterPro:IPR010043"
/db_xref="InterPro:IPR013546"
/db_xref="UniProtKB/Swiss-Prot:P9WN29"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45720.1"
/translation="MEAESPCAASDLAVARRELLSGNHRELDPVGLRQTWLDLHESWL
IDKADEIGIADASGFAIVGVGGLGRRELLPYSDLDVLLLHDGKPADILRPVADRLWYP
LWDANIRLDHSVRTVSEALTIANSDLMAALGMLEARHIAGDQQLSFALIDGVRRQWRN
GIRSRMGELVEMTYARWRRCGRIAQRAEPDLKLGRGGLRDVQLLDALALAQLIDRHGI
GHTDLPAGSLDGAYRTLLDVRTELHRVSGRGRDHLLAQFADEISAALGFGDRFDLART
LSSAGRTIGYHAEAGLRTAANALPRRGISALVRRPKRRPLDEGVVEYAGEIVLARDAE
PEHDPGLVLRVAAASADTGLPIGAATLSRLAASVPDLPTPWPQEALDDLLVVLSAGPT
TVATIEALDRTGLWGRLLPEWEPIRDLPPRDVAHKWTVDRHVVETAVHAAPLATRVAR
PDLLALGALLHDIGKGRGTDHSVLGAELVIPVCTRLGLSPPDVRTLSKLVRHHLLLPI
TATRRDLNDPKTIEAVSEALGGDPQLLEVLHALSEADSKATGPGVWSDWKASLVDDLV
RRCRMVMAGESLPQAEPTAPHYLSLAADHGVHVEISPRDGERIDAVIVAPDERGLVSK
AAAVLALNSLRVHSASVNVHQGVAITEFVVSPLFGSPPAAELVRQQFVGALNGDVDVL
GMLQKRDSDAASLVSARAGDVQAGVPVTRTAAPPRILWLDTAAPAKLILEVRAMDRAG
LLALLAGALEGAGAGIVWAKVNTFGSTAADVFCVTVPAELDARAAVEQHLLEVLGASV
DVVVDEPVGD"
gene complement(3230738..3231076)
/gene="glnB"
/locus_tag="Rv2919c"
CDS complement(3230738..3231076)
/codon_start=1
/transl_table=11
/gene="glnB"
/locus_tag="Rv2919c"
/product="Probable nitrogen regulatory protein P-II GlnB"
/note="Rv2919c, (MTCY338.08c), len: 112 aa. Probable
glnB,nitrogen regulatory protein, highly similar to others
e.g. Q9X705|GLNB PII protein from Corynebacterium
glutamicum (Brevibacterium flavum) (112 aa), FASTA scores:
opt: 531,E(): 4.5e-30, (68.75% identity in 112 aa
overlap); P21193|GLNB_AZOBR nitrogen regulatory protein
P-II from Azospirillum brasilense (112 aa), FASTA scores:
opt: 496,E(): 1.2e-27, (60.7% identity in 112 aa overlap);
P05826|GLNB_ECOLI|B2553|Z3829|ECS3419|STY2808 nitrogen
regulatory protein P-II from Escherichia coli strains K12
and O157:H7 (112 aa), FASTA scores: opt: 487, E():
5.3e-27,(61.6% identity in 112 aa overlap); etc. Contains
PS00496 P-II protein urydylation site. Belongs to the
P(II) protein family."
/db_xref="EnsemblGenomes-Gn:Rv2919c"
/db_xref="EnsemblGenomes-Tr:CCP45721"
/db_xref="GOA:P9WN31"
/db_xref="InterPro:IPR002187"
/db_xref="InterPro:IPR002332"
/db_xref="InterPro:IPR011322"
/db_xref="InterPro:IPR015867"
/db_xref="InterPro:IPR017918"
/db_xref="PDB:3BZQ"
/db_xref="PDB:3LF0"
/db_xref="UniProtKB/Swiss-Prot:P9WN31"
/inference="protein motif:PROSITE:PS00496"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45721.1"
/translation="MKLITAIVKPFTLDDVKTSLEDAGVLGMTVSEIQGYGRQKGHTE
VYRGAEYSVDFVPKVRIEVVVDDSIVDKVVDSIVRAARTGKIGDGKVWVSPVDTIVRV
RTGERGHDAL"
gene complement(3231073..3232506)
/gene="amt"
/locus_tag="Rv2920c"
CDS complement(3231073..3232506)
/codon_start=1
/transl_table=11
/gene="amt"
/locus_tag="Rv2920c"
/product="Probable ammonium-transport integral membrane
protein Amt"
/note="Rv2920c, (MTCY338.09c), len: 477 aa. Probable
amt,ammonium-transport integral membrane protein (ala-,
gly-,leu-, val-rich protein), highly similar to others
e.g. Q9ZBP6|SC7A1.27 ammonium transporter from
Streptomyces coelicolor (448 aa), FASTA scores: opt: 1246,
E(): 7.3e-67,(54.1% identity in 462 aa overlap);
P54146|AMT_CORGL ammonium transport system from
Corynebacterium glutamicum (452 aa), FASTA scores: opt:
953, E(): 2.1e-49, (41.45% identity in 475 aa overlap);
Q07429|NRGA_BACSU probable ammonium transporter (membrane
protein NRGA) from Bacillus subtilis (404 aa), FASTA
scores: opt: 721, E(): 0, (44.4% identity in 430 aa
overlap); etc. Belongs to the AMT1/MEP/NRGA family of
ammonium transporters (TC 2.49)."
/db_xref="EnsemblGenomes-Gn:Rv2920c"
/db_xref="EnsemblGenomes-Tr:CCP45722"
/db_xref="GOA:P9WQ65"
/db_xref="InterPro:IPR001905"
/db_xref="InterPro:IPR018047"
/db_xref="InterPro:IPR024041"
/db_xref="InterPro:IPR029020"
/db_xref="UniProtKB/Swiss-Prot:P9WQ65"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45722.1"
/translation="MDQFPIMGVPDGGDTAWMLVSSALVLLMTPGLAFFYGGMVRSKS
VLNMIMMSISAMGVVTVLWALYGYSIAFGDDVGNIAGNPSQYWGLKGLIGVNAVAADP
STQTAAVNIPLAGTLPATVFVAFQLMFAIITVALISGAVADRLKFGAWLLFAGLWATF
VYFPVAHWVFAFDGFAAEHGGWIANKLHAIDFAGGTAVHINAGVAALMLAIVLGKRRG
WPATLFRPHNLPFVMLGAALLWFGWYGFNAGSATTANGVAGATFVTTTIATAAAMLGW
LLTERVRDGKATTLGAASGIVAGLVAITPSCSSVNVLGALAVGVSAGVLCALAVGLKF
KLGFDDSLDVVGVHLVGGLVGTLLVGLLAAPEAPAINGVAGVSKGLFYGGGFAQLERQ
ALGACSVLVYSGIITLILALILKFTIGLRLDAEQESTGIDEAEHAESGYDFAVASGSV
LPPRVTVEDSRNGIQERIGQKVEAEPK"
gene complement(3232871..3234139)
/gene="ftsY"
/locus_tag="Rv2921c"
CDS complement(3232871..3234139)
/codon_start=1
/transl_table=11
/gene="ftsY"
/locus_tag="Rv2921c"
/product="Probable cell division protein FtsY (SRP
receptor) (signal recognition particle receptor)"
/note="Rv2921c, (MTCY338.10c, MT2989), len: 422 aa.
Probable ftsY, signal recognition particle (SRP)
receptor,a membrane-associated cell division protein (see
citation below), equivalent to O33010|FTSY_MYCLE cell
division protein FTSY homolog from Mycobacterium leprae
(430 aa),FASTA scores: opt: 1760, E(): 1.1e-108, (81.35%
identity in 429 aa overlap). Also similar to others e.g.
Q9I6C1|FTSY|PA0373 signal recognition particle receptor
FTSY from Pseudomonas aeruginosa (455 aa), FASTA scores:
opt: 882, E(): 5.1e-40, (42.08% identity in 385 aa
overlap); Q9KVJ6|FTSY cell division protein from Vibrio
cholerae (391 aa), FASTA scores: opt: 837, E():
1.2e-37,(36.3% identity in 394 aa overlap);
P10121|FTSY_ECOLI|FTSY|B3464 cell division protein from
Escherichia coli strain K12 (497 aa), FASTA scores: opt:
800, E(): 1.3e-35, (39.75% identity in 327 aa overlap);
etc. Also similar to Q9ZBP9|SC7A1.24 putative prokaryotic
docking protein from Streptomyces coelicolor (412
aa),FASTA scores: opt: 1461, E(): 4.3e-71, (60.3% identity
in 423 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A (P-loop), and PS00300 SRP54-type proteins
GTP-binding domain signature. Belongs to the SRP family of
GTP-binding proteins."
/db_xref="EnsemblGenomes-Gn:Rv2921c"
/db_xref="EnsemblGenomes-Tr:CCP45723"
/db_xref="GOA:P9WGD9"
/db_xref="InterPro:IPR000897"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004390"
/db_xref="InterPro:IPR013822"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036225"
/db_xref="InterPro:IPR042101"
/db_xref="UniProtKB/Swiss-Prot:P9WGD9"
/inference="protein motif:PROSITE:PS00300"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45723.1"
/translation="MWEGLWIATAVIAALVVIAALTLGLVLYRRRRISLSPRPERGVV
DRSGGYTASSGITFSQTPTTQPAERIDTSGLPAVGDDATVPRDAPKRTIADVHLPEFE
PEPQAPEVPEADAIAPPEGRLERLRGRLARSQNALGRGLLGLIGGGDLDEDSWQDVED
TLLVADLGPAATASVVSQLRSRLASGNVRTEADARAVLRDVLINELQPGMDRSIRALP
HAGHPSVLLVVGVNGTGKTTTVGKLARVLVADGRRVVLGAADTFRAAAADQLQTWAAR
VGAAVVRGPEGADPASVAFDAVDKGIAAGADVVLIDTAGRLHTKVGLMDELDKVKRVV
TRRASVDEVLLVLDATIGQNGLAQARVFAEVVDISGAVLTKLDGTAKGGIVFRVQQEL
GVPVKLVGLGEGPDDLAPFEPAAFVDALLG"
gene complement(3234189..3237806)
/gene="smc"
/locus_tag="Rv2922c"
CDS complement(3234189..3237806)
/codon_start=1
/transl_table=11
/gene="smc"
/locus_tag="Rv2922c"
/product="Probable chromosome partition protein Smc"
/note="Rv2922c, (MT2990, MTCY338.11c), len: 1205 aa.
Probable smc, chromosome partition protein (ala-,
arg-,leu-, glu-rich protein, possibly coiled-coil protein)
(see * below), equivalent (but longer 84 aa) to
Q9CBT5|SMC|ML1629|MLCB250.01 possible cell division
protein from Mycobacterium leprae (1203 aa), FASTA scores:
opt: 5957, E(): 0, (79.15% identity in 1205 aa overlap).
Also highly similar to other chromosome segregation
proteins e.g. Q9ZBQ2|SC7A1.21 putative chromosome
associated protein from Streptomyces coelicolor (1186 aa),
FASTA scores: opt: 2633, E(): 4.1e-120, (53.03% identity
in 1205 aa overlap); P51834|SMC_BACSU chromosome partition
protein from Bacillus subtilis (1186 aa), FASTA scores:
opt: 1009, E(): 2.1e-41,(30.75% identity in 1205 aa
overlap); Q9CHC9|SMC chromosome segregation protein from
Lactococcus lactis (subsp. lactis) (Streptococcus lactis)
(924 aa), FASTA scores: opt: 996,E(): 7.5e-41, (29.75%
identity in 874 aa overlap); etc. Equivalent to AAK47317
from Mycobacterium tuberculosis strain CDC1551 (1205 aa)
but longer 84 aa. Contains PS00017 ATP/GTP-binding site
motif A (P-loop). Belongs to the SMC family. N-terminus
shortened since first submission. [* Note: Unpublished.
Cobbe N., Heck M.M.S.-Phylogenetic analysis of SMC
proteins (OCT-2001)]."
/db_xref="EnsemblGenomes-Gn:Rv2922c"
/db_xref="EnsemblGenomes-Tr:CCP45724"
/db_xref="GOA:P9WGF3"
/db_xref="InterPro:IPR003395"
/db_xref="InterPro:IPR010935"
/db_xref="InterPro:IPR011890"
/db_xref="InterPro:IPR024704"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036277"
/db_xref="UniProtKB/Swiss-Prot:P9WGF3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45724.1"
/translation="MYLKSLTLKGFKSFAAPTTLRFEPGITAVVGPNGSGKSNVVDAL
AWVMGEQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVSITR
RMFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGKLEEILQSRPEDRRAF
IEEAAGVLKHRKRKEKALRKLDTMAANLARLTDLTTELRRQLKPLGRQAEAAQRAAAI
QADLRDARLRLAADDLVSRRAEREAVFQAEAAMRREHDEAAARLAVASEELAAHESAV
AELSTRAESIQHTWFGLSALAERVDATVRIASERAHHLDIEPVAVSDTDPRKPEELEA
EAQQVAVAEQQLLAELDAARARLDAARAELADRERRAAEADRAHLAAVREEADRREGL
ARLAGQVETMRARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIGELDQGEVG
LDEHHERTVAALRLADERVAELQSAERAAERQVASLRARIDALAVGLQRKDGAAWLAH
NRSGAGLFGSIAQLVKVRSGYEAALAAALGPAADALAVDGLTAAGSAVSALKQADGGR
AVLVLSDWPAPQAPQSASGEMLPSGAQWALDLVESPPQLVGAMIAMLSGVAVVNDLTE
AMGLVEIRPELRAVTVDGDLVGAGWVSGGSDRKLSTLEVTSEIDKARSELAAAEALAA
QLNAALAGALTEQSARQDAAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRL
LQQRTEQEAVRTQTLDDVIQLETQLRKAQETQRVQVAQPIDRQAISAAADRARGVEVE
ARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARAARLHAAAVAAAVADCGR
LLAGRLHRAVDGASQLRDASAAQRQQRLAAMAAVRDEVNTLSARVGELTDSLHRDELA
NAQAALRIEQLEQMVLEQFGMAPADLITEYGPHVALPPTELEMAEFEQARERGEQVIA
PAPMPFDRVTQERRAKRAERALAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARK
DLLGVVADVDARILQVFNDAFVDVEREFRGVFTALFPGGEGRLRLTEPDDMLTTGIEV
EARPPGKKITRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALDDVNLRRLL
SLFEQLREQSQIIIITHQKPTMEVADALYGVTMQNDGITAVISQRMRGQQVDQLVTNS
S"
gene complement(3237818..3238099)
/gene="acyP"
/locus_tag="Rv2922A"
CDS complement(3237818..3238099)
/codon_start=1
/transl_table=11
/gene="acyP"
/locus_tag="Rv2922A"
/product="Probable acylphosphatase AcyP (acylphosphate
phosphohydrolase)"
/note="Rv2922A, len: 93 aa. Probable acyP, acylphosphatase
(acylphosphate phosphohydrolase), highly similar to others
e.g. Q9ZBQ3|SC7A1.20 putative acylphosphatase from
Streptomyces coelicolor (93 aa), FASTA scores: opt:
345,E(): 9.5e-19, (58.9% identity in 90 aa overlap);
P75877|ACYP_ECOLI|YCCX|B0968|Z1320|ECS1052 putative
acylphosphatase from Escherichia coli strains K12 and
O157:H7 (92 aa), FASTA scores: opt: 220, E():
2e-09,(44.95% identity in 89 aa overlap); Q9RVU3|DR0929
putative acylphosphatase from Deinococcus radiodurans (87
aa), FASTA scores: opt: 193, E(): 2.1e-07, (44.3% identity
in 79 aa overlap); etc. Belongs to the acylphosphatase
family."
/db_xref="EnsemblGenomes-Gn:Rv2922A"
/db_xref="EnsemblGenomes-Tr:CCP45725"
/db_xref="GOA:P9WQC9"
/db_xref="InterPro:IPR001792"
/db_xref="InterPro:IPR017968"
/db_xref="InterPro:IPR020456"
/db_xref="InterPro:IPR036046"
/db_xref="UniProtKB/Swiss-Prot:P9WQC9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45725.1"
/translation="MSAPDVRLTAWVHGWVQGVGFRWWTRCRALELGLTGYAANHADG
RVLVVAQGPRAACQKLLQLLQGDTTPGRVAKVVADWSQSTEQITGFSER"
gene complement(3238086..3238499)
/locus_tag="Rv2923c"
CDS complement(3238086..3238499)
/codon_start=1
/transl_table=11
/locus_tag="Rv2923c"
/product="Conserved protein"
/note="Rv2923c, (MTCY338.12c), len: 137 aa. Conserved
protein, showing similarity with other hypothetical
proteins e.g. P24246|YHFA_ECOLI|B3356|Z4717|ECS4207 from
Escherichia coli strains K12 and O157:H7 (134 aa), FASTA
scores: opt: 110, E(): 1.9, (25.9% identity in 135 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2923c"
/db_xref="EnsemblGenomes-Tr:CCP45726"
/db_xref="GOA:P9WL19"
/db_xref="InterPro:IPR003718"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR036102"
/db_xref="UniProtKB/Swiss-Prot:P9WL19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45726.1"
/translation="MTQLWVERTGTRRYIGRSTRGAQVLVGSEDVDGVFTPGELLKIA
LAACSGMASDQPLARRLGDDYQAVVKVSGAADRDQERYPLIEETMELDLSGLTEDEKE
RLLVVINRAVELACTVGRTLKSGTTVNLEVVDVGA"
gene complement(3238601..3239470)
/gene="fpg"
/gene_synonym="mutM"
/locus_tag="Rv2924c"
CDS complement(3238601..3239470)
/codon_start=1
/transl_table=11
/gene="fpg"
/gene_synonym="mutM"
/locus_tag="Rv2924c"
/product="Probable formamidopyrimidine-DNA glycosylase Fpg
(FAPY-DNA glycosylase)"
/note="Rv2924c, (MTCY338.13c), len: 289 aa. Probable fpg
(alternate gene name: mutM), formamidopyrimidine-DNA
glycosylase (see citation below), equivalent to
O69470|FPG_MYCLE formamidopyrimidine-DNA glycosylase from
Mycobacterium leprae (282 aa), FASTA scores: opt:
1563,E(): 1.3e-96, (80.6% identity in 289 aa overlap).
Also highly similar to other formamidopyrimidine-DNA
glycosylases e.g. Q9ZBQ6|FPG_STRCO from Streptomyces
coelicolor (286 aa), FASTA scores: opt: 1047, E():
2.9e-62,(57.55% identity in 292 aa overlap);
P95744|FPG_SYNEN from Synechococcus elongatus naegeli (284
aa), FASTA scores: opt: 569, E(): 1.9e-30, (37.95%
identity in 290 aa overlap);
P05523|FPG_ECOLI|MUTM|FPG|B3635 from Escherichia coli
strain K12 (269 aa), FASTA scores: opt: 424, E(): 8.2e-21,
(33.9% identity in 289 aa overlap); etc. Belongs to the
FPG family. Cofactor: binds 1 zinc ion."
/db_xref="EnsemblGenomes-Gn:Rv2924c"
/db_xref="EnsemblGenomes-Tr:CCP45727"
/db_xref="GOA:P9WNC3"
/db_xref="InterPro:IPR000214"
/db_xref="InterPro:IPR010663"
/db_xref="InterPro:IPR010979"
/db_xref="InterPro:IPR012319"
/db_xref="InterPro:IPR015886"
/db_xref="InterPro:IPR015887"
/db_xref="InterPro:IPR020629"
/db_xref="InterPro:IPR035937"
/db_xref="UniProtKB/Swiss-Prot:P9WNC3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45727.1"
/translation="MPELPEVEVVRRGLQAHVTGRTITEVRVHHPRAVRRHDAGPADL
TARLRGARINGTDRRGKYLWLTLNTAGVHRPTDTALVVHLGMSGQMLLGAVPCAAHVR
ISALLDDGTVLSFADQRTFGGWLLADLVTVDGSVVPVPVAHLARDPLDPRFDCDAVVK
VLRRKHSELKRQLLDQRVVSGIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHAAA
DVMREALAKGGTSFDSLYVNVNGESGYFERSLDAYGREGENCRRCGAVIRRERFMNRS
SFYCPRCQPRPRK"
gene complement(3239829..3240551)
/gene="rnc"
/locus_tag="Rv2925c"
CDS complement(3239829..3240551)
/codon_start=1
/transl_table=11
/gene="rnc"
/locus_tag="Rv2925c"
/product="Probable ribonuclease III Rnc (RNase III)"
/note="Rv2925c, (MTCY338.14c), len: 240 aa. Probable
rnc,ribonuclease III (RNase III), equivalent to
O69469|RNC_MYCLE ribonuclease III from Mycobacterium
leprae (238 aa). Also highly similar to other
ribonucleases III e.g. Q9ZBQ7|RNC_STRCO from Streptomyces
coelicolor (272 aa), FASTA scores: opt: 889, E(): 5.4e-51,
(62.2% identity in 225 aa overlap) (N-terminus longer 21
aa); P51833|RNC_BACSU from Bacillus subtilis (249 aa),
FASTA scores: opt: 493, E(): 5e-25, (43.25% identity in
215 aa overlap); P05797|RNC_ECOLI|RNC|B2567|Z3848|ECS3433
from Escherichia coli strain O157:H7 and K12 (226 aa),
FASTA scores: opt: 459, E(): 7.9e-23, (41.8% identity in
213 aa overlap); etc. Contains PS00517 Ribonuclease III
family signature."
/db_xref="EnsemblGenomes-Gn:Rv2925c"
/db_xref="EnsemblGenomes-Tr:CCP45728"
/db_xref="GOA:P9WH03"
/db_xref="InterPro:IPR000999"
/db_xref="InterPro:IPR011907"
/db_xref="InterPro:IPR014720"
/db_xref="InterPro:IPR036389"
/db_xref="PDB:2A11"
/db_xref="UniProtKB/Swiss-Prot:P9WH03"
/inference="protein motif:PROSITE:PS00517"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45728.1"
/translation="MIRSRQPLLDALGVDLPDELLSLALTHRSYAYENGGLPTNERLE
FLGDAVLGLTITDALFHRHPDRSEGDLAKLRASVVNTQALADVARRLCAEGLGVHVLL
GRGEANTGGADKSSILADGMESLLGAIYLQHGMEKAREVILRLFGPLLDAAPTLGAGL
DWKTSLQELTAARGLGAPSYLVTSTGPDHDKEFTAVVVVMDSEYGSGVGRSKKEAEQK
AAAAAWKALEVLDNAMPGKTSA"
gene complement(3240548..3241171)
/locus_tag="Rv2926c"
CDS complement(3240548..3241171)
/codon_start=1
/transl_table=11
/locus_tag="Rv2926c"
/product="Conserved protein"
/note="Rv2926c, (MTCY338.15c), len: 207 aa. Conserved
protein, equivalent to O69468|ML1660|MLCB1243.14
hypothetical 23.5 KDA protein from Mycobacterium leprae
(217 aa), FASTA scores: opt: 866, E(): 1.4e-48, (67.2%
identity in 192 aa overlap). Also similar in part to other
hypothetical proteins e.g. Q9WXZ8 conserved hypothetical
protein from Thermotoga maritima (182 aa), FASTA scores:
opt: 254, E(): 3.4e-09, (31.45% identity in 143 aa
overlap); Q9ZBQ9|SC7A1.14 hypothetical 23.5 KDA protein
from Streptomyces coelicolor (217 aa), FASTA scores: opt:
244, E(): 1.7e-08, (45.5% identity in 189 aa overlap);
O65982 hypothetical 26.2 KDA protein from Clostridium
thermosaccharolyticum (Thermoanaerobacterium
thermosaccharolyticum) (228 aa), FASTA scores: opt:
220,E(): 6.1e-07, (32.45% identity in 148 aa overlap);
etc. Equivalent to AAK47323 from Mycobacterium
tuberculosis strain CDC1551 (195 aa) but longer 12 aa."
/db_xref="EnsemblGenomes-Gn:Rv2926c"
/db_xref="EnsemblGenomes-Tr:CCP45729"
/db_xref="InterPro:IPR003772"
/db_xref="UniProtKB/Swiss-Prot:P9WL17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45729.1"
/translation="MDLGGVRRRISLMARQHGPTAQRHVASPMTVDIARLGRRPGAMF
ELHDTVHSPARIGLELIAIDQGALLDLDLRVESVSEGVLVTGTVAAPTVGECARCLSP
VRGRVQVALTELFAYPDSATDETTEEDEVGRVVDETIDLEQPIIDAVGLELPFSPVCR
PDCPGLCPQCGVPLASEPGHRHEQIDPRWAKLVEMLGPESDTLRGER"
gene complement(3241222..3241959)
/locus_tag="Rv2927c"
CDS complement(3241222..3241959)
/codon_start=1
/transl_table=11
/locus_tag="Rv2927c"
/product="Conserved hypothetical protein"
/note="Rv2927c, (MTCY338.16c), len: 245 aa. Conserved
hypothetical protein, equivalent to
Q9CBS6|ML1661|MLCB1243.13 (alias O69467) hypothetical
protein from Mycobacterium leprae (247 aa), FASTA scores:
opt: 1440, E(): 4.9e-76, (90.6% identity in 245 aa
overlap). Also similar to many hypothetical proteins from
other organisms e.g. Q9ZBR0|SC7A1.13 hypothetical 41.0 KDA
protein from Streptomyces coelicolor (379 aa), FASTA
scores: opt: 266, E(): 3.4e-08, (29.9% identity in 234 aa
overlap); etc. Also some similarity with
P46815|AG84_MYCLE|ML0922 antigen 84 from Mycobacterium
leprae (266 aa), FASTA scores: opt: 193, E():
0.00043,(28.7% identity in 136 aa overlap) (see citation
below); and P46816|AG84_MYCTU|WAG31|Rv2145c|MT2204|MTCY270
.23 antigen 84 from Mycobacterium tuberculosis (260 aa),
FASTA scores: opt: 178, E(): 0.0031, (34.35% identity in
131 aa overlap) (see citation below). Contains potential
coiled-coil region."
/db_xref="EnsemblGenomes-Gn:Rv2927c"
/db_xref="EnsemblGenomes-Tr:CCP45730"
/db_xref="UniProtKB/Swiss-Prot:P9WL15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45730.1"
/translation="MYRVFEALDELSAIVEEARGVPMTAGCVVPRGDVLELIDDIKDA
IPGELDDAQDVLDARDSMLQDAKTHADSMVSSATTEAESILNHARTEADRILSDAKAQ
ADRMVSEARQHSERMVADAREEAIRIATAAKREYEASVSRAQAECDRLIENGNISYEK
AVQEGIKEQQRLVSQNEVVAAANAESTRLVDTAHAEADRLRGECDIYVDNKLAEFEEF
LNGTLRSVGRGRHQLRTAAGTHDYAVR"
gene 3242198..3242983
/gene="tesA"
/locus_tag="Rv2928"
CDS 3242198..3242983
/codon_start=1
/transl_table=11
/gene="tesA"
/locus_tag="Rv2928"
/product="Probable thioesterase TesA"
/note="Rv2928, (MTCY338.17), len: 261 aa. Probable
tesA,thioesterase, similar to many e.g. Q9L4W2|NYSE
thioesterase involved in synthesis of the polyene
antifungal antibiotic nystatin from Streptomyces noursei
(see Brautaset et al.,2000) (251 aa). TesA|Rv2928
interacts with PpsE|Rv2935, by bacterial two-hybrid and
GST-pulldown assays (See Rao and Ranganathan, 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2928"
/db_xref="EnsemblGenomes-Tr:CCP45731"
/db_xref="GOA:P9WQD5"
/db_xref="InterPro:IPR001031"
/db_xref="InterPro:IPR012223"
/db_xref="InterPro:IPR020802"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:6FVJ"
/db_xref="UniProtKB/Swiss-Prot:P9WQD5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45731.1"
/translation="MLARHGPRYGGSVNGHSDDSSGDAKQAAPTLYIFPHAGGTAKDY
VAFSREFSADVKRIAVQYPGQHDRSGLPPLESIPTLADEIFAMMKPSARIDDPVAFFG
HSMGGMLAFEVALRYQSAGHRVLAFFVSACSAPGHIRYKQLQDLSDREMLDLFTRMTG
MNPDFFTDDEFFVGALPTLRAVRAIAGYSCPPETKLSCPIYAFIGDKDWIATQDDMDP
WRDRTTEEFSIRVFPGDHFYLNDNLPELVSDIEDKTLQWHDRA"
gene 3242970..3243281
/locus_tag="Rv2929"
CDS 3242970..3243281
/codon_start=1
/transl_table=11
/locus_tag="Rv2929"
/product="Hypothetical protein"
/note="Rv2929, (MTCY338.18), len: 103 aa. Hypothetical
unknown protein; some weak similarity to C-terminal half
of P18319|UREG_KLEAE urease accessory protein from
klebsiella aerogenes (205 aa), FASTA scores: opt: 99, E():
1.1, (38.6% identity in 57 aa overlap). This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv2929"
/db_xref="EnsemblGenomes-Tr:CCP45732"
/db_xref="GOA:P9WL13"
/db_xref="UniProtKB/Swiss-Prot:P9WL13"
/protein_id="CCP45732.1"
/translation="MIELSYAPDVAGRRSNWPKGSGVNTWTAIRWTFAEDSPYVGTGL
ERMASDTHGGGGGRPVTPPPPGMHHLGCSRGVLLISSQRDAGHKTCDPAAGGTLTSVL
T"
gene 3243697..3245448
/gene="fadD26"
/locus_tag="Rv2930"
CDS 3243697..3245448
/codon_start=1
/transl_table=11
/gene="fadD26"
/locus_tag="Rv2930"
/product="Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP
synthetase) (fatty-acid-AMP synthase)"
/note="Rv2930, (MT2999, MTCY338.19), len: 583 aa.
FadD26,fatty-acid-AMP synthetase, equivalent to
Q9Z5K5|FADD26|ML2358|MLCB12.03c probable acyl-CoA synthase
from Mycobacterium leprae (583 aa), FASTA scores: opt:
3026, E(): 9.2e-180, (76.85% identity in 583 aa overlap).
Also highly similar to many e.g. Q9CD84|ML0132 putative
acyl-CoA synthetase from Mycobacterium leprae (680
aa),FASTA scores: opt: 2324, E(): 3.2e-136, (61.35%
identity in 572 aa overlap); P71495 acyl-CoA synthase from
Mycobacterium bovis (582 aa), FASTA scores: opt: 2304,
E(): 5e-135, (59.85% identity in 583 aa overlap); etc.
Also highly similar to others from Mycobacterium
tuberculosis e.g. Q50586|FD25_MYCTU|RV1521|MTCY19G5.07
putative fatty-acid--CoA ligase (583 aa), FASTA scores:
opt: 2188,E(): 7.6e-128, (57.55% identity in 584 aa
overlap); etc. Belongs to the ATP-dependent AMP-binding
enzyme family. N-terminus shortened since first
submission. Note that Rv2930|fadD26 belongs to the
transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven
experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2930"
/db_xref="EnsemblGenomes-Tr:CCP45733"
/db_xref="GOA:P9WQ43"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ43"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45733.1"
/translation="MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWS
QVYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIH
DDRVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAF
SRQHTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLP
LYHDMGLILGICAPLVARRRAMLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELA
VRRTSDQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEA
TLYVAAPEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPE
TMVENPPGVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLG
VISDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAII
EFKRRGSTAEEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSA
CVERYRSDGFKRLDVAV"
gene 3245445..3251075
/gene="ppsA"
/locus_tag="Rv2931"
CDS 3245445..3251075
/codon_start=1
/transl_table=11
/gene="ppsA"
/locus_tag="Rv2931"
/product="Phenolpthiocerol synthesis type-I polyketide
synthase PpsA"
/note="Rv2931, (MTCY338.20), len: 1876 aa. PpsA, type-I
polyketide synthase (see citations below), highly similar
to others from Mycobacterium leprae e.g.
Q9Z5K6|ML2357|MLCB12.02c putative polyketide synthase from
Mycobacterium leprae (1871 aa), FASTA scores: opt:
7566,E(): 0, (76.1% identity in 1888 aa overlap);
Q9S384|ML2356|MLCB12.01c putative polyketide synthase from
Mycobacterium leprae (1540 aa), FASTA scores: opt:
4026,E(): 9.8e-212, (45.7% identity in 1811 aa overlap);
Q49932|PKSC|L518_F1_2 putative polyketide synthase (1446
aa), FASTA scores: opt: 4026, E(): 9.4e-212, (70.6%
identity in 885 aa overlap). Also similar to polyketide
synthases from other bacteria e.g. C-terminus of
Q9L8C7|EPOC polyketide synthase from Polyangium cellulosum
(7257 aa), FASTA scores: opt: 2592, E(): 5.2e-133, (32.55%
identity in 2245 aa overlap); P22367|MSAS_PENPA
6-methylsalicylic acid synthase from Penicillium patulum
(Penicillium griseofulvum) (1774 aa), FASTA scores: opt:
2391, E(): 0, (34.2% identity in 1815 aa overlap); etc.
And also highly similar to others from Mycobacterium
tuberculosis e.g. Q10978|PPSB_MYCTU|RV2932
phenolpthiocerol synthesis polyketide synthase (1538 aa),
FASTA scores: opt: 4227, E(): 0, (46.8% identity in 1810
aa overlap) (gap in middle); etc. Contains PS00606
Beta-ketoacyl synthases active site, and PS00012
Phosphopantetheine attachment site. Note that Rv2931|ppsA
belongs to the transcriptional unit
Rv2930|fadD26-Rv2939|papA5 (proven experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2931"
/db_xref="EnsemblGenomes-Tr:CCP45734"
/db_xref="GOA:P9WQE7"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:P9WQE7"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45734.1"
/translation="MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSR
DAVVLSGELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARNSLDE
PIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQRWQPFEGGPPEVAAALARTT
RWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWEALEHAGIPPGTLRRSATG
VFAGACLSEYGAMASADLSQVDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSS
LVAIHLACQSLRTQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGF
VRGEGAGVVVLKRLTDAQRDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVLRAAY
TNAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLLIGSVKTNLGHTE
AAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDLRMKVVDTQTEWPATGHPRRA
GVSSFGFGGTNAHVVIEQGQEVRPAPGQGLSPAVSTLVVAGKTMQRVSATAGMLADWM
EGPGADVALADVAHTLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVNPAD
GSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVLANG
EELVGIEQIQLGLIGMQLALTELWCSYGVRPDLVIGHSMGEVAAAVVAGALTPAEGLR
VTATRSRLMAPLSGQGGMALLELDAPTTEALIADFPQVTLGIYNSPRQTVIAGPTEQI
DELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELADLTPRTPTIGIISTTYAD
LHTQPVFDAEHWATNMRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLH
SAQPGARYTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTPHPPEPHPPIPTTPWQHTR
HWITTKYPAGSVGSAPRAGTLLGQHTTVATVSASPPSHLWQARLAPDAKPYQGGHRFH
QVEVVPASVVLHTILSAATELGYSALSEVRFEQPIFADRPRLIQVVADNRAISLASSP
AAGTPSDRWTRHVTAQLSSSPSDSASSLNEHHRANGQPPERAHRDLIPDLAELLAMRG
IDGLPFSWTVASWTQHSSNLTVAIDLPEALPEGSTGPLLDAAVHLAALSDVADSRLYV
PASIEQISLGDVVTGPRSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALD
FGLDVGRAQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIG
DDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAVRICTEITG
LVRTLAERDADKPAALWILTRGVHESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDL
AINDDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEPARKSLQCRPDAAYL
ITGGLGALGLLMADWLADRGAHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALE
MRGVTVEAVAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVR
QVMWPKIGGSQVLHDAFPPGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARR
QQGCHTMSLDWVAWRGLGLAADAQLVSEELARMGSRDITPSEAFTAWEFVDGYDVAQA
VVVPMPAPAGADGSGANAYLLPARNWSVMAATEVRSELEQGLRRIIAAELRVPEKELD
TDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLFNHPTVKSLASYLAKRVAPHDVS
QDNQISALSSSAGSVLDSLFDRIESAPPEAERSV"
gene 3251072..3255688
/gene="ppsB"
/locus_tag="Rv2932"
CDS 3251072..3255688
/codon_start=1
/transl_table=11
/gene="ppsB"
/locus_tag="Rv2932"
/product="Phenolpthiocerol synthesis type-I polyketide
synthase PpsB"
/note="Rv2932, (MTV011.01, MTCY338.21, MT3002), len: 1538
aa. PpsB, type-I polyketide synthase (see citations
below),highly similar to others from Mycobacterium leprae
e.g. Q9S384|ML2356|MLCB12.01c putative polyketide synthase
(1540 aa), FASTA scores: opt: 7284, E(): 0, (76.3%
identity in 1561 aa overlap); Q49932|PKSC|L518_F1_2
putative polyketide synthase (1446 aa), FASTA scores: opt:
6811, E(): 0, (76.2% identity in 1462 aa overlap); etc.
Also similar to polyketide synthases from other bacteria
e.g. Q9KIZ6|EPOE EPOE protein from Polyangium cellulosum
(3798 aa), FASTA scores: opt: 3052, E(): 3.3e-165, (38.35%
identity in 1538 aa overlap); etc. And also highly similar
to others from Mycobacterium tuberculosis e.g.
Q10977|PPSA_MYCTU|RV2931 phenolpthiocerol synthesis
polyketide synthase (1876 aa),FASTA scores: opt: 4227,
E(): 0, (46.9% identity in 1810 aa overlap);
P96203|PPSD|Rv2934|MTCY19H9.02 PKSE protein (1827 aa),
FASTA scores: opt: 3756, E(): 1.8e-205, (42.9% identity in
1808 aa overlap); etc. Overlaps and extends CDS from
neighbouring cosmid MTCY338.21. Contains PS00606
Beta-ketoacyl synthases active site. Note that Rv2932|ppsB
belongs to the transcriptional unit
Rv2930|fadD26-Rv2939|papA5 (proven experimentally).
Nucleotide position 3254365 in the genome sequence has
been corrected, T:C resulting in L1098L."
/db_xref="EnsemblGenomes-Gn:Rv2932"
/db_xref="EnsemblGenomes-Tr:CCP45735"
/db_xref="GOA:P9WQE5"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/Swiss-Prot:P9WQE5"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45735.1"
/translation="MMRTAFSRISGMTAQQRTSLADEFDRVSRIAVAEPVAVVGIGCR
FPGDVDGPESFWDFLVAGRNAISTVPADRWDAEAFYHPDPLTPGRMTTKWGGFVPDVA
GFDAEFFGITPREAAAMDPQQRMLLEVAWEALEHAGIPPDSLGGTRTAVMMGVYFNEY
QSMLAASPQNVDAYSGTGNAHSITVGRISYLLGLRGPAVAVDTACSSSLVAVHLACQS
LRLRETDLALAGGVSITLRPETQIAISAWGLLSPQGRCAAFDAAADGFVRGEGAGVVV
LKRLTDAVRDGDQVLAVVRGSAVNQDGRSNGVTAPNTAAQCDVIADALRSGDVAPDSV
NYVEAHGTGTVLGDPIEFEALAATYGHGGDACALGAVKTNIGHLEAAAGIAGFIKATL
AVQRATIPPNLHFSQWNPAIDAASTRFFVPTQNSPWPTAEGPRRAAVSSFGLGGTNAH
VIIEQGSELAPVSEGGEDTGVSTLVVTGKTAQRMAATAQVLADWMEGPGAEVAVADVA
HTVNHHRARQATFGTVVARDRAQAIAGLRALAAGQHAPGVVSHQDGSPGPGTVFVYSG
RGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLRDVIATGKELVGIEQIQLGL
IGMQLTLTELWRSYGVQPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRARLMAPLS
GQGGMALLGLDAAATEALIADYPQVTVGIYNSPRQTVIAGPTEQIDELIARVRAQNRF
ASRVNIEVAPHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQPIFDAEHWA
TNMRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIADTLEDAHRPTKSAAKYL
SIGTLQRDADDTVTFRTNLYTADIAHPPHTCHPPEPHPTIPTTPWQHTHHWIATTHPS
TAAPEDPGSNKVVVNGQSTSESRALEDWCHQLAWPIRPAVSADPPSTAAWLVVADNEL
CHELARAADSRVDSLSPPALAAGSDPAALLDALRGVDNVLYAPPVPGELLDIESAYQV
FHATRRLAAAMVASSATAISPPKLFIMTRNAQPISEGDRANPGHAVLWGLGRSLALEH
PEIWGGIIDLDDSMPAELAVRHVLTAAHGTDGEDQVVYRSGARHVPRLQRRTLPGKPV
TLNADASQLVIGATGNIGPHLIRQLARMGAKTIVAMARKPGALDELTQCLAATGTDLI
AVAADATDPAAMQTLFDRFGTELPPLEGIYLAAFAGRPALLSEMTDDDVTTMFRPKLD
ALALLHRRSLKSPVRHFVLFSSVSGLLGSRWLAHYTATSAFLDSFAGARRTMGLPATV
VDWGLWKSLADVQKDATQISAESGLQPMADEVAIGALPLVMNPDAAVATVVVAADWPL
LAAAYRTRGALRIVDDLLPAPEDVGKGESEFRTSLRSCPAEKRRDMLFDHVGALAATV
MGMPPTEPLDPSAGFFQLGMDSLMSVTLQRALSESLGEFLPASVVFDYPTVYSLTDYL
ATVLPELLEIGATAVATQQATDSYHELTEAELLEQLSERLRGTQ"
gene 3255685..3262251
/gene="ppsC"
/locus_tag="Rv2933"
CDS 3255685..3262251
/codon_start=1
/transl_table=11
/gene="ppsC"
/locus_tag="Rv2933"
/product="Phenolpthiocerol synthesis type-I polyketide
synthase PpsC"
/note="Rv2933, (MTCY19H9.01, MTV011.02), len: 2188 aa.
ppsC, type-I polyketide synthase (see citations
below),highly similar to others from Mycobacterium leprae
e.g. Q49933|PKSD|ML2355|L518_F1_3 putative polyketide
synthase (2201 aa), FASTA scores: opt: 6973, E(): 0,
(82.32% identity in 2217 aa overlap);
Q49624|PKS3|MASA|ML1229|B1170_C2_209 probable mycocerosic
acid synthase (2118 aa), FASTA scores: opt: 4015, E():
2.9e-208, (36.6% identity in 2184 aa overlap); etc. Also
similar to polyketide synthases from other bacteria e.g.
C-terminus of Q9L8C7 polyketide synthase from Polyangium
cellulosum (7257 aa), FASTA scores: opt: 3909, E():
3.6e-202, (40.15% identity in 2220 aa overlap);
Q9KIZ7|EPOD EPOD protein from Polyangium cellulosum (7257
aa), FASTA scores: opt: 3886, E(): 6.2e-201, (40.05%
identity in 2220 aa overlap); etc. And also highly similar
to others from Mycobacterium tuberculosis e.g.
P96291|Rv2940c (2111 aa),FASTA scores: opt: 4204, E(): 0,
(39.1% identity in 2176 aa overlap);
Q10977|PPSA_MYCTU|RV2931 phenolpthiocerol synthesis
polyketide synthase (1876 aa), FASTA scores: opt: 3793,
E(): 2.4e-196, (46.65% identity in 1612 aa overlap); etc.
Contains PS00606 Beta-ketoacyl synthases active site,and
PS00012 Phosphopantetheine attachment site. Note that
Rv2933|ppsC belongs to the transcriptional unit
Rv2930|fadD26-Rv2939|papA5 (proven experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2933"
/db_xref="EnsemblGenomes-Tr:CCP45736"
/db_xref="GOA:P96202"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="PDB:1PQW"
/db_xref="PDB:4OKI"
/db_xref="PDB:4OOC"
/db_xref="PDB:5I0K"
/db_xref="PDB:5L84"
/db_xref="PDB:5NJI"
/db_xref="UniProtKB/Swiss-Prot:P96202"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45736.1"
/translation="MTAATPDRRAIITEALHKIDDLTARLEIAEKSSSEPIAVIGMGC
RFPGGVNNPEQFWDLLCAGRSGIVRVPAQRWDADAYYCDDHTVPGTICSTEGGFLTSW
QPDEFDAEFFSISPREAAAMDPQQRLLIEVAWEALEDAGVPQHTIRGTQTSVFVGVTA
YDYMLTLAGRLRPVDLDAYIPTGNSANFAAGRLAYILGARGPAVVIDTACSSSLVAVH
LACQSLRGRESDMALVGGTNLLLSPGPSIACSRWGMLSPEGRCKTFDASADGYVRGEG
AAVVVLKRLDDAVRDGNRILAVVRGSAVNQDGASSGVTVPNGPAQQALLAKALTSSKL
TAADIDYVEAHGTGTPLGDPIELDSLSKVFSDRAGSDQLVIGSVKTNLGHLEAAAGVA
GLMKAVLAVHNGYIPRHLNFHQLTPHASEAASRLRIAADGIDWPTTGRPRRAGVSSFG
VSGTNAHVVIEQAPDPMAAAGTEPQRGPVPAVSTLVVFGKTAPRVAATASVLADWLDG
PGAAVPLADVAHTLNHHRARQTRFGTVAAVDRRQAVIGLRALAAGQSAPGVVAPREGS
IGGGTVFVYSGRGSQWAGMGRQLLADEPAFAAAIAELEPEFVAQGGFSLRDVIAGGKE
LVGIEQIQLGLIGMQLALTALWRSYGVTPDAVIGHSMGEVAAAVVAGALTPAQGLRVT
AVRSRLMAPLSGQGTMALLELDAEATEALIADYPEVSLGIYASPRQTVISGPPLLIDE
LIDKVRQQNGFATRVNIEVAPHNPAMDALQPAMRSELADLTPQPPTIPIISTTYADLG
ISLGSGPRFDAEHWATNMRNPVRFHQAIAHAGADHHTFIEISAHPLLTHSISDTLRAS
YDVDNYLSIGTLQRDAHDTLEFHTNLNTTHTTHPPQTPHPPEPHPVLPTTPWQHTQHW
ITATSAAYHRPDTHPLLGVGVTDPTNGTRVWESELDPDLLWLADHVIDDLVVLPGAAY
AEIALAAATDTFAVEQDQPWMISELDLRQMLHVTPGTVLVTTLTGDEQRCQVEIRTRS
GSSGWTTHATATVARAEPLAPLDHEGQRREVTTADLEDQLDPDDLYQRLRGAGQQHGP
AFQGIVGLAVTQAGVARAQVRLPASARTGSREFMLHPVMMDIALQTLGATRTATDLAG
GQDARQGPSSNSALVVPVRFAGVHVYGDITRGVRAVGSLAAAGDRLVGEVVLTDANGQ
PLLVVDEVEMAVLGSGSGATELTNRLFMLEWEPAPLEKTAEATGALLLIGDPAAGDPL
LPALQSSLRDRITDLELASAADEATLRAAISRTSWDGIVVVCPPRANDESMPDEAQLE
LARTRTLLVASVVETVTRMGARKSPRLWIVTRGAAQFDAGESVTLAQTGLRGIARVLT
FEHSELNTTLVDIEPDGTGSLAALAEELLAGSEADEVALRDGQRYVNRLVPAPTTTSG
DLAAEARHQVVNLDSSGASRAAVRLQIDQPGRLDALNVHEVKRGRPQGDQVEVRVVAA
GLNFSDVLKAMGVYPGLDGAAPVIGGECVGYVTAIGDEVDGVEVGQRVIAFGPGTFGT
HLGTIADLVVPIPDTLADNEAATFGVAYLTAWHSLCEVGRLSPGERVLIHSATGGVGM
AAVSIAKMIGARIYTTAGSDAKREMLSRLGVEYVGDSRSVDFADEILELTDGYGVDVV
LNSLAGEAIQRGVQILAPGGRFIELGKKDVYADASLGLAALAKSASFSVVDLDLNLKL
QPARYRQLLQHILQHVADGKLEVLPVTAFSLHDAADAFRLMASGKHTGKIVISIPQHG
SIEAIAAPPPLPLVSRDGGYLIVGGMGGLGFVVARWLAEQGAGLIVLNGRSAPSDEVA
AAIAELNASGSRIEVITGDITEPDTAERLVRAVEDAGFRLAGVVHSAMVLADEIVLNM
TDSAARRVFAPKVTGSWRLHVATAARDVDWWLTFSSAAALLGTPGQGAYAAANSWVDG
LVAHRRSAGLPAVGINWGPWADVGRAQFFKDLGVEMINAEQGLAAMQAVLTADRGRTG
VFSLDARQWFQSFPAVAGSSLFAKLHDSAARKSGQRRGGGAIRAQLDALDAAERPGHL
ASAIADEIRAVLRSGDPIDHHRPLETLGLDSLMGLELRNRLEASLGITLPVALVWAYP
TISDLATALCERMDYATPAAAQEISDTEPELSDEEMDLLADLVDASELEAATRGES"
gene 3262248..3267731
/gene="ppsD"
/locus_tag="Rv2934"
CDS 3262248..3267731
/codon_start=1
/transl_table=11
/gene="ppsD"
/locus_tag="Rv2934"
/product="Phenolpthiocerol synthesis type-I polyketide
synthase PpsD"
/note="Rv2934, (MTCY19H9.02), len: 1827 aa. PpsD, type-I
polyketide synthase (see citations below), highly similar
to others from Mycobacterium leprae e.g. Q9CB70|ML2354
polyketide synthase (1822 aa), FASTA scores: opt:
9779,E(): 0, (80.35% identity in 1836 aa overlap);
Q49940|L518_F3_67|PFSE (1815 aa), FASTA scores: opt:
9658,E(): 0, (79.85% identity in 1831 aa overlap); etc.
Also similar to polyketide synthases from other bacteria
e.g. C-terminus of Q9RNB2|MCYD|Q9FDU1 polyketide synthase
(MCYD protein) from Microcystis aeruginosa (3906 aa),
FASTA scores: opt: 2961, E(): 6e-159, (32.15% identity in
1827 aa overlap); etc. And also highly similar to others
from Mycobacterium tuberculosis e.g.
Q10978|PPSB_MYCTU|RV2932 phenolpthiocerol synthesis
polyketide synthase (1538 aa),FASTA scores: opt: 3756,
E(): 3.8e-204, (42.85% identity in 1808 aa overlap) (gaps
in middle); P96202|PPSC|RV2933 polyketide synthase (2188
aa), FASTA scores: opt: 3463,E(): 1.7e-187, (39.2%
identity in 2165 aa overlap); etc. Contains PS00606
Beta-ketoacyl synthases active site,PS00017
ATP/GTP-binding site motif A, PS00013 Prokaryotic membrane
lipoprotein lipid attachment site, and PS00012
Phosphopantetheine attachment site. Note that Rv2934|ppsD
belongs to the transcriptional unit
Rv2930|fadD26-Rv2939|papA5 (proven experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2934"
/db_xref="EnsemblGenomes-Tr:CCP45737"
/db_xref="GOA:P9WQE3"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:P9WQE3"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00013"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45737.1"
/translation="MTSLAERAAQLSPNARAALARELVRAGTTFPTDICEPVAVVGIG
CRFPGNVTGPESFWQLLADGVDTIEQVPPDRWDADAFYDPDPSASGRMTTKWGGFVSD
VDAFDADFFGITPREAVAMDPQHRMLLEVAWEALEHAGIPPDSLSGTRTGVMMGLSSW
DYTIVNIERRADIDAYLSTGTPHCAAVGRIAYLLGLRGPAVAVDTACSSSLVAIHLAC
QSLRLRETDVALAGGVQLTLSPFTAIALSKWSALSPTGRCNSFDANADGFVRGEGCGV
VVLKRLADAVRDQDRVLAVVRGSATNSDGRSNGMTAPNALAQRDVITSALKLADVTPD
SVNYVETHGTGTVLGDPIEFESLAATYGLGKGQGESPCALGSVKTNIGHLEAAAGVAG
FIKAVLAVQRGHIPRNLHFTRWNPAIDASATRLFVPTESAPWPAAAGPRRAAVSSFGL
SGTNAHVVVEQAPDTAVAAAGGMPYVSALNVSGKTAARVASAAAVLADWMSGPGAAAP
LADVAHTLNRHRARHAKFATVIARDRAEAIAGLRALAAGQPRVGVVDCDQHAGGPGRV
FVYSGQGSQWASMGQQLLANEPAFAKAVAELDPIFVDQVGFSLQQTLIDGDEVVGIDR
IQPVLVGMQLALTELWRSYGVIPDAVIGHSMGEVSAAVVAGALTPEQGLRVITTRSRL
MARLSGQGAMALLELDADAAEALIAGYPQVTLAVHASPRQTVIAGPPEQVDTVIAAVA
TQNRLARRVEVDVASHHPIIDPILPELRSALADLTPQPPSIPIISTTYESAQPVADAD
YWSANLRNPVRFHQAVTAAGVDHNTFIEISPHPVLTHALTDTLDPDGSHTVMSTMNRE
LDQTLYFHAQLAAVGVAASEHTTGRLVDLPPTPWHHQRFWVTDRSAMSELAATHPLLG
AHIEMPRNGDHVWQTDVGTEVCPWLADHKVFGQPIMPAAGFAEIALAAASEALGTAAD
AVAPNIVINQFEVEQMLPLDGHTPLTTQLIRGGDSQIRVEIYSRTRGGEFCRHATAKV
EQSPRECAHAHPEAQGPATGTTVSPADFYALLRQTGQHHGPAFAALSRIVRLADGSAE
TEISIPDEAPRHPGYRLHPVVLDAALQSVGAAIPDGEIAGSAEASYLPVSFETIRVYR
DIGRHVRCRAHLTNLDGGTGKMGRIVLINDAGHIAAEVDGIYLRRVERRAVPLPLEQK
IFDAEWTESPIAAVPAPEPAAETTRGSWLVLADATVDAPGKAQAKSMADDFVQQWRSP
MRRVHTADIHDESAVLAAFAETAGDPEHPPVGVVVFVGGASSRLDDELAAARDTVWSI
TTVVRAVVGTWHGRSPRLWLVTGGGLSVADDEPGTPAAASLKGLVRVLAFEHPDMRTT
LVDLDITQDPLTALSAELRNAGSGSRHDDVIAWRGERRFVERLSRATIDVSKGHPVVR
QGASYVVTGGLGGLGLVVARWLVDRGAGRVVLGGRSDPTDEQCNVLAELQTRAEIVVV
RGDVASPGVAEKLIETARQSGGQLRGVVHAAAVIEDSLVFSMSRDNLERVWAPKATGA
LRMHEATADCELDWWLGFSSAASLLGSPGQAAYACASAWLDALVGWRRASGLPAAVIN
WGPWSEVGVAQALVGSVLDTISVAEGIEALDSLLAADRIRTGVARLRADRALVAFPEI
RSISYFTQVVEELDSAGDLGDWGGPDALADLDPGEARRAVTERMCARIAAVMGYTDQS
TVEPAVPLDKPLTELGLDSLMAVRIRNGARADFGVEPPVALILQGASLHDLTADLMRQ
LGLNDPDPALNNADTIRDRARQRAAARHGAAMRRRPKPEVQGG"
gene 3267737..3272203
/gene="ppsE"
/locus_tag="Rv2935"
CDS 3267737..3272203
/codon_start=1
/transl_table=11
/gene="ppsE"
/locus_tag="Rv2935"
/product="Phenolpthiocerol synthesis type-I polyketide
synthase PpsE"
/note="Rv2935, (MTCY19H9.03), len: 1488 aa. PpsE, type-I
polyketide synthase (see citations below). Contains
PS00606 Beta-ketoacyl synthases active site. Note that
Rv2935|ppsE belongs to the transcriptional unit
Rv2930|fadD26-Rv2939|papA5 (proven experimentally).
TesA|Rv2928 interacts with PpsE|Rv2935, by bacterial
two-hybrid and GST-pulldown assays (See Rao and
Ranganathan, 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2935"
/db_xref="EnsemblGenomes-Tr:CCP45738"
/db_xref="GOA:P9WQE1"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036736"
/db_xref="UniProtKB/Swiss-Prot:P9WQE1"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45738.1"
/translation="MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQE
LRDAGVSDKTLADPAYVRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCAWHA
LEDAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDK
DFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHR
VGYFTSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGS
AINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQG
LRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSP
NPELRLDQSPFVVQSKYGPWECDGVRRAGVSSFGVGGTNAHVVLEEAPAEASEVSAHA
EPAGPQVILLSAQTAAALGESRTALAAALETQDGPRLSDVAYTLARRRKHNVTMAAVV
HDREHAATVLRAAEHDNVFVGEAAHDGEHGDRADAAPTSDRVVFLFPGQGAQHVGMAK
GLYDTEPVFAQHFDTCAAGFRDETGIDLHAEVFDGTATDLERIDRSQPALFTVEYALA
KLVDTFGVRAGAYIGYSTGEYIAATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVA
LGPDDVTQYLPPEVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFH
TSAMDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISSPIRFA
DELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRHPLQDVDDRDTFLR
ALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRHWVEPNHTVWAQAPGANNGSPA
GTADGSTAATVDAARNGESQTEVTLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISIA
MAAANEGLTITPQDLYEYPTLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLD
RGLRDTGRCRVPLILRLDPKIGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAP
AEFTGLSNRSVPNGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAHGGPHY
LCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGWREWSLRCAALATHP
AALDTRSYWIENSTKATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRR
RFRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVGWFTTYYPV
PLACATGLGALAQLDAVHNTLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYA
GVIPELPSGDAPVQFDSDMTLPVREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPA
ATAEALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMDAG"
gene 3272214..3273209
/gene="drrA"
/locus_tag="Rv2936"
CDS 3272214..3273209
/codon_start=1
/transl_table=11
/gene="drrA"
/locus_tag="Rv2936"
/product="Daunorubicin-dim-transport ATP-binding protein
ABC transporter DrrA"
/note="Rv2936, (MTCY19H9.04), len: 331 aa.
drrA,daunorubicin-dim-transport resistance ATP-binding
protein ABC transporter, probably involved in daunorubicin
resistance and phthiocerol dimycocerosate transport (see
citations below), equivalent to
Q49938|DRRA|ML2352|L518_F2_43|DRRA probable daunorubicin
resistance ATP-binding protein from Mycobacterium leprae
(331 aa), FASTA scores: opt: 1842, E(): 4.2e-103, (85.2%
identity in 331 aa overlap). Also highly similar to others
e.g. Q9XCF7 DRRA from Mycobacterium avium (315 aa), FASTA
scores: opt: 1040, E(): 4.7e-55, (54.35% identity in 309
aa overlap); Q9X5J8 daunorubicin resistance protein A from
Mycobacterium avium (315 aa), FASTA scores: opt: 1030,
E(): 1.9e-54, (53.7% identity in 309 aa overlap);
P32010|DRRA_STRPE daunorubicin resistance ATP-binding
protein from Streptomyces peucetius (330 aa), FASTA
scores: opt: 852, E(): 9e-44, (47.15% identity in 318 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop), and PS00211 ABC transporters family signature.
Belongs to the ATP-binding transport protein family (ABC
transporters). Note that Rv2936|drrA belongs to the
transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven
experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2936"
/db_xref="EnsemblGenomes-Tr:CCP45739"
/db_xref="GOA:P9WQL9"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005894"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQL9"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45739.1"
/translation="MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGPN
GAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQVAVDDALSGEQN
LVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTYSGGMRRRIDIACGLVVQPQ
VAFLDEPTTGLDPRSRQAIWDLVASFKKLGIATLLTTQYLEEADALSDRIILIDHGII
IAEGTANELKHRAGDTFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPA
PDGIRMLVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGSAR"
gene 3273206..3274075
/gene="drrB"
/locus_tag="Rv2937"
CDS 3273206..3274075
/codon_start=1
/transl_table=11
/gene="drrB"
/locus_tag="Rv2937"
/product="Daunorubicin-dim-transport integral membrane
protein ABC transporter DrrB"
/note="Rv2937, (MTCY19H9.05), len: 289 aa.
drrB,daunorubicin-dim-transport integral membrane protein
ABC transporter, probably involved in daunorubicin
resistance and phthiocerol dimycocerosate transport (see
citations below), equivalent to
Q49935|DRRB|ML2351|L518_F1_9 daunorubicin resistance
transmembrane protein from Mycobacterium leprae (288 aa),
FASTA scores: opt: 1252,E(): 5.3e-72, (64.0% identity in
289 aa overlap). Also similar to others e.g. Q9XCF8 DRRB
protein from Mycobacterium avium (246 aa), FASTA scores:
opt: 423, E(): 1.5e-19, (30.85% identity in 243 aa
overlap); Q9S6H4 daunorubicin resistance protein B from
Mycobacterium avium (246 aa), FASTA scores: opt: 420, E():
2.3e-19, (30.85% identity in 243 aa overlap);
P32011|DRRB_STRPE daunorubicin resistance transmembrane
protein from Streptomyces peucetius (283 aa), FASTA
scores: opt: 242, E(): 4.7e-08,(27.85% identity in 219 aa
overlap); etc. Note that Rv293|drrB belongs to the
transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven
experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2937"
/db_xref="EnsemblGenomes-Tr:CCP45740"
/db_xref="GOA:P9WG23"
/db_xref="InterPro:IPR000412"
/db_xref="InterPro:IPR004377"
/db_xref="UniProtKB/Swiss-Prot:P9WG23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45740.1"
/translation="MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSL
LNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFA
AIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGF
RFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGL
MPLKLFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVI
LALSSTIVLARRP"
gene 3274072..3274902
/gene="drrC"
/locus_tag="Rv2938"
CDS 3274072..3274902
/codon_start=1
/transl_table=11
/gene="drrC"
/locus_tag="Rv2938"
/product="Probable daunorubicin-dim-transport integral
membrane protein ABC transporter DrrC"
/note="Rv2938, (MTCY19H9.06), len: 276 aa. Probable
drrC,daunorubicin-dim-transport integral membrane protein
ABC transporter, probably involved in daunorubicin
resistance and phthiocerol dimycocerosate transport (see
citations below), equivalent to Q9CB71|ML2350 probable
antibiotic resistance membrane protein from Mycobacterium
leprae (276 aa), FASTA scores: opt: 1434, E(): 1.2e-81,
(79.0% identity in 276 aa overlap); and
Q49941|DRRC|L518_F3_76 putative daunorubicin resistance
transmembrane protein from Mycobacterium leprae (244 aa),
FASTA scores: opt: 1194,E(): 8.3e-67, (76.85% identity in
242 aa overlap). Also similar to others e.g. Q9XCF9 DRRC
protein from Mycobacterium avium (263 aa), FASTA scores:
opt: 538, E(): 3.7e-26, (32.65% identity in 251 aa
overlap); Q9S6H3 daunorubicin resistance protein C from
Mycobacterium avium (263 aa), FASTA scores: opt: 533, E():
7.6e-26, (32.25% identity in 251 aa overlap);
P32011|DRRB_STRPE daunorubicin resistance transmembrane
protein from Streptomyces peucetius (283 aa), FASTA
scores: opt: 276, E(): 6.6e-10,(21.07% identity in 261 aa
overlap); etc. Note that Rv2938|drrC belongs to the
transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven
experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2938"
/db_xref="EnsemblGenomes-Tr:CCP45741"
/db_xref="GOA:P9WG21"
/db_xref="InterPro:IPR000412"
/db_xref="InterPro:IPR004377"
/db_xref="InterPro:IPR005943"
/db_xref="InterPro:IPR013525"
/db_xref="UniProtKB/Swiss-Prot:P9WG21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45741.1"
/translation="MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARD
YITVIGAIVLPILFMVVLNIVLGNLAYVVTHDSGLYSIVPLIALGAAITGSTFVAIDL
MRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTTLVMLGTGVVLGFRFRQGLIP
SLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLVPLNSYPGW
IQPFVAHQPVSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH
"
gene 3274949..3276217
/gene="papA5"
/locus_tag="Rv2939"
CDS 3274949..3276217
/codon_start=1
/transl_table=11
/gene="papA5"
/locus_tag="Rv2939"
/product="Possible conserved polyketide synthase
associated protein PapA5"
/note="Rv2939, (MTCY19H9.07), len: 422 aa. Possible
papA5,conserved polyketide synthase (PKS) associated
protein (see Camacho et al., 2001), equivalent to Q49939
hypothetical 45.6 KDA protein from Mycobacterium leprae
(423 aa), FASTA scores: opt: 2398, E(): 4.5e-144, (84.05%
identity in 426 aa overlap); and Q02279|YMA3_MYCBO
hypothetical 38.1 KDA protein from Mycobacterium bovis
(354 aa), FASTA scores: opt: 2193, E(): 3.6e-131, (97.4%
identity in 343 aa overlap). And C-terminus highly similar
to to Q9S381 hypothetical 5.0 KDA protein (fragment) from
Mycobacterium leprae (44 aa), FASTA scores: opt: 275, E():
1.4e-10,(88.65% identity in 44 aa overlap). Also similar
in part to various synthetases e.g. Q9AE01|RIF20 RIF20
protein from Amycolatopsis mediterranei (Nocardia
mediterranei) (403 aa), FASTA scores: opt: 282, E():
2.7e-10, (30.3% identity in 393 aa overlap); middle part
of Q00869|ESYN1 enniatin sythetase (fragment) (N-methyl
peptide synthetase) from Fusarium equiseti (3131 aa),
FASTA scores: opt: 180, E(): 0.0036, (26.85% identity in
242 aa overlap); N-terminus of Q9FB18 peptide synthetase
NRPS2-1 from Streptomyces verticillus (2626 aa), FASTA
scores: opt: 159, E(): 0.068,(23.65% identity in 351 aa
overlap); etc. Note that Rv2939|papA5 belongs to the
transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven
experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2939"
/db_xref="EnsemblGenomes-Tr:CCP45742"
/db_xref="GOA:P9WIN5"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR031641"
/db_xref="PDB:1Q9J"
/db_xref="UniProtKB/Swiss-Prot:P9WIN5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45742.1"
/translation="MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFD
ALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSV
SLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPT
PLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWL
SKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPV
APTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGT
PPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEH
HGHIAEPGKSLEAIRSLLCTVPSEYGWIME"
gene complement(3276380..3282715)
/gene="mas"
/locus_tag="Rv2940c"
CDS complement(3276380..3282715)
/codon_start=1
/transl_table=11
/gene="mas"
/locus_tag="Rv2940c"
/product="Probable multifunctional mycocerosic acid
synthase membrane-associated Mas"
/note="Rv2940c, (MTCY24G1.09, MTCY19H9.08c), len: 2111 aa.
Probable mas, mycocerosic acid synthase membrane
associated, multifunctional enzyme (see citations
below),almost identical to Q02251|MCAS_MYCBO|mas
mycocerosic acid synthase from Mycobacterium bovis (2110
aa), FASTA scores: opt: 13226, E(): 0, (95.8% identity in
2115 aa overlap) (see Mathur & Kolattukudy 1992); and
equivalent to Q9CD78|mas|ML0139 putative mycocerosic
synthase from Mycobacterium leprae (2116 aa), FASTA
scores: opt: 12142,E(): 0, (87.95% identity in 2119 aa
overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209
probable mycocerosic acid synthase from Mycobacterium
leprae (2118 aa), FASTA scores: opt: 8421, E(): 0, (60.8%
identity in 2127 aa overlap). Also similar to other
synthases e.g. C-terminus of Q9L8C7|EPOC polyketide
synthase from Polyangium cellulosum (7257 aa), FASTA
scores: opt: 4332, E(): 0,(40.85% identity in 2149 aa
overlap); etc. Also similar to others from Mycobacterium
tuberculosis e.g. O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.
01 polyketide synthase (2108 aa), FASTA scores: opt: 5059,
E(): 0, (65.9% identity in 2121 aa overlap); etc. Contains
several domains, organized in the following order:
beta-ketoacyl synthase (PS00606), acyl transferase,
dehydratase-enoyl reductase, beta-ketoreductase, acyl
carrier protein. Contains PS00012 Phosphopantetheine
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2940c"
/db_xref="EnsemblGenomes-Tr:CCP45743"
/db_xref="GOA:I6Y231"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/TrEMBL:I6Y231"
/inference="protein motif:PROSITE:PS00012"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45743.1"
/translation="MESRVTPVAVIGMGCRLPGGINSPDKLWESLLRGDDLVTEIPPD
RWDADDYYDPEPGVPGRSVSRWGGFLDDVAGFDAEFFGISEREATSIDPQQRLLLETS
WEAIEHAGLDPASLAGSSTAVFTGLTHEDYLVLTTTAGGLASPYVVTGLNNSVASGRI
AHTLGLHGPAMTFDTACSSGLMAVHLACRSLHDGEADLALAGGCAVLLEPHASVAASA
QGMLSSTGRCHSFDADADGFVRSEGCAMVLLKRLPDALRDGNRIFAVVRGTATNQDGR
TETLTMPSEDAQVAVYRAALAAAGVQPETVGVVEAHGTGTPIGDPIEYRSLARVYGAG
TPCALGSAKSNMGHSTASAGTVGLIKAILSLRHGVVPPLLHFNRLPDELSDVETGLFV
PQAVTPWPNGNDHTPKRVAVSSFGMSGTNVHAIVEEAPAEASAPESSPGDAEVGPRLF
MLSSTSSDALRQTARQLATWVEEHQDCVAASDLAYTLARGRAHRPVRTAVVAANLPEL
VEGLREVADGDALYDAAVGHGDRGPVWVFSGQGSQWAAMGTQLLASEPVFAATIAKLE
PVIAAESGFSVTEAITAQQTVTGIDKVQPAVFAVQVALAATMEQTYGVRPGAVVGHSM
GESAAAVVAGALSLEDAARVICRRSKLMTRIAGAGAMGSVELPAKQVNSELMARGIDD
VVVSVVASPQSTVIGGTSDTVRDLIARWEQRDVMAREVAVDVASHSPQVDPILDDLAA
ALADIAPMTPKVPYYSATLFDPREQPVCDGAYWVDNLRNTVQFAAAVQAAMEDGYRVF
AELSPHPLLTHAVEQTGRSLDMSVAALAGMRREQPLPHGLRGLLTELHRAGAALDYSA
LYPAGRLVDAPLPAWTHARLFIDDDGQEQRAQGACTITVHPLLGSHVRLTEEPERHVW
QGDVGTSVLSWLSDHQVHNVAALPGAAYCEMALAAAAEVFGEAAEVRDITFEQMLLLD
EQTPIDAVASIDAPGVVNFTVETNRDGETTRHATAALRAAEDDCPPPGYDITALLQAH
PHAVNGTAMRESFAERGVTLGAAFGGLTTAHTAEAGAATVLAEVALPASIRFQQGAYR
IHPALLDACFQSVGAGVQAGTATGGLLLPLGVRSLRAYGPTRNARYCYTRLTKAFNDG
TRGGEADLDVLDEHGTVLLAVRGLRMGTGTSERDERDRLVSERLLTLGWQQRALPEVG
DGEAGSWLLIDTSNAVDTPDMLASTLTDALKSHGPQGTECASLSWSVQDTPPNDQAGL
EKLGSQLRGRDGVVIVYGPRVGDPDEHSLLAGREQVRHLVRITRELAEFEGELPRLFV
VTRQAQIVKPHDSGERANLEQAGLRGLLRVISSEHPMLRTTLIDVDEHTDVERVAQQL
LSGSEEDETAWRNGDWYVARLTPSPLGHEERRTAVLDPDHDGMRVQVRRPGDLQTLEF
VASDRVPPGPGQIEVAVSMSSINFADVLIAFGRFPIIDDREPQLGMDFVGVVTAVGEG
VTGHQVGDRVGGFSEGGCWRTFLTCDANLAVTLPPGLTDEQAITAATAHATAWYGLND
LAQIKAGDKVLIHSATGGVGQAAISIARAKGAEIFATAGNPAKRAMLRDMGVEHVYDS
RSVEFAEQIRRDTDGYGVDIVLNSLTGAAQRAGLELLAFGGRFVEIGKADVYGNTRLG
LFPFRRGLTFYYLDLALMSVTQPDRVRELLATVFKLTADGVLTAPQCTHYPLAEAADA
IRAMSNAEHTGKLVLDVPRSGRRSVAVTPEQAPLYRRDGSYIITGGLGGLGLFFASKL
AAAGCGRIVLTARSQPNPKARQTIEGLRAAGADIVVECGNIAEPDTADRLVSAATATG
LPLRGVLHSAAVVEDATLTNITDELIDRDWSPKVFGSWNLHRATLGQPLDWFCLFSSG
AALLGSPGQGAYAAANSWVDVFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEIMI
TPEEGAYAFETLVRHDRAYSGYIPILGAPWLADLVRRSPWGEMFASTGQRSRGPSKFR
MELLSLPQDEWAGRLRRLLVEQASVILRRTIDADRSFIEYGLDSLGMLEMRTHVETET
GIRLTPKVIATNNTARALAQYLADTLAEEQAAAPAAS"
gene 3283335..3285077
/gene="fadD28"
/gene_synonym="acoas"
/locus_tag="Rv2941"
CDS 3283335..3285077
/codon_start=1
/transl_table=11
/gene="fadD28"
/gene_synonym="acoas"
/locus_tag="Rv2941"
/product="Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP
synthetase) (fatty-acid-AMP synthase)"
/note="Rv2941, (MTCY24G1.08c), len: 580 aa. FadD28
(alternate gene name: acoas), fatty-acid-AMP synthetase
(see citations below), almost identical to P71495 acyl-CoA
synthase from Mycobacterium bovis (582 aa), FASTA scores:
opt: 3828, E(): 0, (99.15% identity in 580 aa overlap);
and equivalent to Q9CD79|FADD28|ML0138 acyl-CoA synthetase
from Mycobacterium leprae (579 aa), FASTA scores: opt:
3183,E(): 8.8e-186, (81.9% identity in 580 aa overlap).
And also highly similar to others Mycobacteria proteins
e.g. O07797|FADD23|Rv3826|MTCY409.04c putative
fatty-acid-CoA synthetase from Mycobacterium tuberculosis
(584 aa); etc. Contains PS00018 EF-hand calcium-binding
domain. Note that Rv2941|fadD28 and Rv2942|mmpL7 are
transcriptionally coupled (proven experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2941"
/db_xref="EnsemblGenomes-Tr:CCP45744"
/db_xref="GOA:P9WQ59"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="PDB:3E53"
/db_xref="PDB:3T5A"
/db_xref="UniProtKB/Swiss-Prot:P9WQ59"
/inference="protein motif:PROSITE:PS00018"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45744.1"
/translation="MSVRSLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQL
YRRTLNVAQELSRCGSTGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDE
RSDSVLSDSSPVAILTTSSAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKED
EYPSTAYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWLP
FYHDMGLVIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELA
ARRTTDDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEA
TVYVATSKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTC
IECPDGTVGEIWVHGDNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFV
TDGKMFIIGRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAISVPGDRSTEKLVAIIE
LKKRGDSDQDAMARLGAIKREVTSALSSSHGLSVADLVLVAPGSIPITTSGKVRRGAC
VEQYRQDQFARLDA"
gene 3285070..3287832
/gene="mmpL7"
/locus_tag="Rv2942"
CDS 3285070..3287832
/codon_start=1
/transl_table=11
/gene="mmpL7"
/locus_tag="Rv2942"
/product="Conserved transmembrane transport protein MmpL7"
/note="Rv2942, (MTCY24G1.07c), len: 920 aa.
MmpL7,conserved transmembrane transport protein (see
citations below), member of RND superfamily, highly
similar to Q9XB10 hypothetical 99.5 KDA protein from
Mycobacterium bovis BCG (945 aa), FASTA scores: opt: 488,
E(): 4.9e-20, (29.5% identity in 918 aa overlap); and to
others from Mycobacteria e.g. O53735|MML4_MYCTU from
Mycobacterium tuberculosis (945 aa), FASTA scores: opt:
481, E(): 1.2e-19, (25.9% identity in 922 aa overlap);
etc. Also similar to other membrane proteins e.g.
O54101|MMLB_STRCO|SC10A5.10c putative membrane protein
from Streptomyces coelicolor (847 aa), FASTA scores: opt:
256,E(): 7.2e-07, (25.15% identity in 545 aa overlap);
etc. Contains PS00639 Eukaryotic thiol (cysteine)
proteases histidine active site, PS00079 Multicopper
oxidases signature 1, and PS00044 Bacterial regulatory
proteins,lysR family signature. Belongs to the MmpL
family. Note that Rv2941|fadD28 and Rv2942|mmpL7 are
transcriptionally coupled (proven experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2942"
/db_xref="EnsemblGenomes-Tr:CCP45745"
/db_xref="GOA:P9WJU7"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJU7"
/inference="protein motif:PROSITE:PS00639"
/inference="protein motif:PROSITE:PS00044"
/inference="protein motif:PROSITE:PS00079"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45745.1"
/translation="MPSPAGRLHRIRYIRLKKSSPDCRATITSGSADGQRRSPRLTNL
LVVAAWVAAAVIANLLLTFTQAEPHDTSPALLPQDAKTAAATSRIAQAFPGTGSNAIA
YLVVEGGSTLEPQDQPYYDAAVGALRADTRHVGSVLDWWSDPVTAPLGTSPDGRSATA
MVWLRGEAGTTQAAESLDAVRSVLRQLPPSEGLRASIVVPAITNDMPMQITAWQSATI
VTVAAVIAVLLLLRARLSVRAAAIVLLTADLSLAVAWPLAAVVRGHDWGTDSVFSWTL
AAVLTIGTITAATMLAARLGSDAGHSAAPTYRDSLPAFALPGACVAIFTGPLLLARTP
ALHGVGTAGLGVFVALAASLTVLPALIALAGASRQLPAPTTGAGWTGRLSLPVSSASA
LGTAAVLAICMLPIIGMRWGVAENPTRQGGAQVLPGNALPDVVVIKSARDLRDPAALI
AINQVSHRLVEVPGVRKVESAAWPAGVPWTDASLSSAAGRLADQLGQQAGSFVPAVTA
IKSMKSIIEQMSGAVDQLDSTVNVTLAGARQAQQYLDPMLAAARNLKNKTTELSEYLE
TIHTWIVGFTNCPDDVLCTAMRKVIEPYDIVVTGMNELSTGADRISAISTQTMSALSS
APRMVAQMRSALAQVRSFVPKLETTIQDAMPQIAQASAMLKNLSADFADTGEGGFHLS
RKDLADPSYRHVRESMFSSDGTATRLFLYSDGQLDLAAAARAQQLEIAAGKAMKYGSL
VDSQVTVGGAAQIAAAVRDALIHDAVLLAVILLTVVALASMWRGAVHGAAVGVGVLAS
YLAALGVSIALWQHLLDRELNALVPLVSFAVLASCGVPYLVAGIKAGRIADEATGARS
KGAVSGRGAVAPLAALGGVFGAGLVLVSGGSFSVLSQIGTVVVLGLGVLITVQRAWLP
TTPGRR"
mobile_element 3288463..3290504
/mobile_element_type="insertion sequence:IS1533"
/note="IS1533, len: 2042 nt. Minimum region corresponding
to Insertion sequence IS1533."
gene 3288464..3289705
/locus_tag="Rv2943"
CDS 3288464..3289705
/codon_start=1
/transl_table=11
/locus_tag="Rv2943"
/product="Probable transposase for insertion sequence
element IS1533"
/note="Rv2943, (MTCY24G1.06c), len: 413 aa. Probable
transposase for insertion sequence IS1533, similar to
other transposases e.g. P15025|ISTA_ECOLI ista protein
(insertion sequence IS21) from Escherichia coli (390 aa),
FASTA scores: opt: 268, E(): 5.1e-11, (24.1% identity in
378 aa overlap). Contains potential helix-turn-helix motif
at aa 19-40 (Score 1611, +4.67 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2943"
/db_xref="EnsemblGenomes-Tr:CCP45746"
/db_xref="GOA:I6X5T4"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="UniProtKB/TrEMBL:I6X5T4"
/protein_id="CCP45746.1"
/translation="MLTVEDWAEIRRLHRAEGLPIKMIARVLGISKNTVKSALESNQQ
PKYERAPQGSIVDAVEPRIRELLQAYPTMPATVIAERIGWERSIRVLSARVAELRPVY
LPPDPASRTTYVAGEIAQCDFWFPPIELPVGFGQTRTAKQLPVLTMVCAYSRWLLAML
LPSRCAEDLFAGWWRLIEALGAVPRVLVWDGEGAIGRWRGGRSELTTECQAFRGTLAA
KVLICRPADPEAKGLIERAHDYLERSFLPGRVFASPADFNAQLGAWLALVNTRTRRAL
GCAPTDRIGADRAAMLSLPPVAPATGWCTSLRLPRDHYVRCDSNDYSVHPGVIGHRVL
VRADLERVHVFCDGELVADHERIWAVHQTVSDPAHVEAAKVLRRRHFSAASPVVEPQV
QVRSLSDYDDALGVDIDGGVA"
gene 3289705..3290235
/locus_tag="Rv2943A"
CDS 3289705..3290235
/codon_start=1
/transl_table=11
/locus_tag="Rv2943A"
/product="Possible transposase"
/note="Rv2943A, len: 176 aa. Possible transposase, similar
to many e.g. AJ238712|MBO238712_2 putative transposase
(IS21-l) from Mycobacterium bovis BCG (266 aa), FASTA
scores: opt: 762, E(): 0, (100.0% identity in 118 aa
overlap). Possible frameshift after codon 118 i.e. near
position 3290056, to fuse with Rv2944."
/db_xref="EnsemblGenomes-Gn:Rv2943A"
/db_xref="EnsemblGenomes-Tr:CCP45747"
/db_xref="GOA:Q6MX22"
/db_xref="InterPro:IPR002611"
/db_xref="UniProtKB/TrEMBL:Q6MX22"
/protein_id="CCP45747.1"
/translation="MPTTKATQRRDVSTEIAYLTRALKAPTLRESVSRLADRARAENW
SHEEYLAACLQREVSARESHGGEGRIRAARFPARKSLEEFDFEHARGLKRDTIAHLGT
LDFITARDNVVFLGPAWHREDSSCGRPGDTRVSGRSSGAVRHRRRMGSTARRGSPRRA
HLRRTHPALPLSAPGG"
gene 3289790..3290506
/locus_tag="Rv2944"
CDS 3289790..3290506
/codon_start=1
/transl_table=11
/locus_tag="Rv2944"
/product="Possible transposase for insertion sequence
element IS1533"
/note="Rv2944, (MTCY24G1.05c), len: 238 aa. Possible
transposase for IS1533, similar to is-element proteins
e.g. P15026|ISTB_ECOLI istb protein from Escherichia coli
(265 aa), FASTA scores: opt: 475, E (): 1.6e-21, (48.0%
identity in 148 aa overlap); Z95436|MTY15C10_14 from
Mycobacterium tuberculosis (248 aa), FASTA scores: opt:
784, E(): 0,(87.4% identity in 135 aa overlap). Contains
PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2944"
/db_xref="EnsemblGenomes-Tr:CCP45748"
/db_xref="GOA:P96287"
/db_xref="InterPro:IPR002611"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P96287"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45748.1"
/translation="MSQCPGWPIAPAPRTGATKNTWPPACSGKCQPGSPMVVRAASAP
PASRLGSRWKSSTLSMLVASNATPSHIWAPWISSPPAITSCFWAPPGTGKTHLAVGLA
IRACQAGHRVLFATAAEWVARLAEAHHAGRIYAELTRLCRYPLLVVDEVGYIPFEPEA
ANLFFQLVSSRYERASLIVTSNKAFGRWGEVFGGDDVVAAAMIDRLVHHAEVVALKGD
SYRLKDRDLGRVPPAGTTEE"
gene complement(3290624..3291325)
/gene="lppX"
/locus_tag="Rv2945c"
CDS complement(3290624..3291325)
/codon_start=1
/transl_table=11
/gene="lppX"
/locus_tag="Rv2945c"
/product="Probable conserved lipoprotein LppX"
/note="Rv2945c, (MTCY24G1.04), len: 233 aa. Probable
lppX,conserved lipoprotein, equivalent to Q9CD80 putative
lipoprotein from Mycobacterium leprae (233 aa), FASTA
scores: opt: 1165, E(): 2.1e-65, (76.4% identity in 233 aa
overlap); and similar to Q9CCP6|ML0557 from Mycobacterium
leprae (238 aa), FASTA scores: opt: 338, E():
7.4e-14,(30.75% identity in 231 aa overlap). Also similar
to others from Mycobacterium tuberculosis e.g.
P71679|LPRG_MYCTU lipoprotein (236 aa), FASTA scores: opt:
342, E(): 4.1e-14,(32.05% identity in 231 aa overlap);
etc. Contains PS00013 Prokaryotic membrane lipoprotein
lipid attachment site, and has in its N-terminal a signal
peptide. Belongs to the LPPX/lprafg family of
lipoproteins. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2945c"
/db_xref="EnsemblGenomes-Tr:CCP45749"
/db_xref="GOA:P9WK65"
/db_xref="InterPro:IPR009830"
/db_xref="InterPro:IPR029046"
/db_xref="PDB:2BYO"
/db_xref="UniProtKB/Swiss-Prot:P9WK65"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45749.1"
/translation="MNDGKRAVTSAVLVVLGACLALWLSGCSSPKPDAEEQGVPVSPT
ASDPALLAEIRQSLDATKGLTSVHVAVRTTGKVDSLLGITSADVDVRANPLAAKGVCT
YNDEQGVPFRVQGDNISVKLFDDWSNLGSISELSTSRVLDPAAGVTQLLSGVTNLQAQ
GTEVIDGISTTKITGTIPASSVKMLDPGAKSARPATVWIAQDGSHHLVRASIDLGSGS
IQLTQSKWNEPVNVD"
gene complement(3291503..3296353)
/gene="pks1"
/locus_tag="Rv2946c"
CDS complement(3291503..3296353)
/codon_start=1
/transl_table=11
/gene="pks1"
/locus_tag="Rv2946c"
/product="Probable polyketide synthase Pks1"
/note="Rv2946c, (MTCY24G1.03), len: 1616 aa. Probable
pks1,polyketide synthase, similar to many e.g.
ML035|AL583917|Q9CD81 putative polyketide synthase from
Mycobacterium leprae (2103 aa), Fasta scores: opt:
8761,E(): 0, (82.6% identity in 1620 aa overlap); etc.
Almost identical in part to G560507|Q50470 PKS002C protein
from Mycobacterium tuberculosis (fragment) (950 aa), Fasta
scores: opt: 5685, E(): 0, (95.3% identity in 927 aa
overlap). Also similar to Mycobacterium tuberculosis
polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6%
identity in 1632 aa); pks12|Rv2048c|O53490 (4151 aa)
(58.0% identity in 1606 aa); pks8|rv1662|O65933 (1602 aa)
(59.7% identity in 1144 aa). Contains a PS00012
Phosphopantetheine attachment site. Note pks1 has been
shown to be involved in the biosynthesis of phthiocerol.
pks15/pks1 has been shown to be involved in the
biosynthesis of phenolphthiocerol glycolipids."
/db_xref="EnsemblGenomes-Gn:Rv2946c"
/db_xref="EnsemblGenomes-Tr:CCP45750"
/db_xref="GOA:P96285"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:P96285"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45750.1"
/translation="MISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEH
RAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELY
GELPVFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVL
RDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAAS
EDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSP
LMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSA
RHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFT
TGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGA
VVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEE
LVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAE
TPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGE
AGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARF
ASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSP
ISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTA
LEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLID
TDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLED
LVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETG
PEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLAD
LAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGD
SRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEI
AANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFM
SQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRR
GDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL
DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYS
AANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAE
AVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDAT
SSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTA
VELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAA
EVSVHA"
gene complement(3296350..3297840)
/gene="pks15"
/locus_tag="Rv2947c"
CDS complement(3296350..3297840)
/codon_start=1
/transl_table=11
/gene="pks15"
/locus_tag="Rv2947c"
/product="Probable polyketide synthase Pks15"
/note="Rv2947c, (MTCY24G1.02), len: 496 aa. Probable
pks15,polyketide synthase. Almost identical to
G560508|Q50469 PKS002B protein from Mycobacterium
tuberculosis (495 aa),FASTA scores: opt: 3270, E(): 0,
(99.6% identity in 496 a a overlap). Similar to
Mycobacterium tuberculosis proteins
MTCY338.20|RV2931|PPSA_MYCTU ppsA phenolpthiocerol
synthesis (1876 aa) (49.9% identity in 465 aa overlap);
MTCY24G1.09|RV2940C|P96291 Putative mas, mycocerosic acid
synthase (2111 aa) (50.2% identity in 454 aa overlap); and
MTCY22H8.03|RV2382C|P71718 hypothetical protein (444 aa)
(47.6% identity in 437 aa overlap). Contains PS00606
Beta-ketoacyl synthases active site. Note pks15 has been
shown to be involved in the biosynthesis of phthiocerol.
pks15/pks1 has been shown to be involved in the
biosynthesis of phenolphthiocerol glycolipids."
/db_xref="EnsemblGenomes-Gn:Rv2947c"
/db_xref="EnsemblGenomes-Tr:CCP45751"
/db_xref="GOA:P96284"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR015083"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036299"
/db_xref="UniProtKB/Swiss-Prot:P96284"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45751.1"
/translation="MIEEQRTMSVEGADQQSEKLFHYLKKVAVELDETRARLREYEQR
ATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEG
KTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDPLSLRG
SATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYVLGLQGPAVSVDTACSS
SLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADG
TGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQVA
LANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWVGSIKSNMGHT
QAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSVDGRPRR
AAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGRGRRWCRG"
gene complement(3297837..3299954)
/gene="fadD22"
/locus_tag="Rv2948c"
CDS complement(3297837..3299954)
/codon_start=1
/transl_table=11
/gene="fadD22"
/locus_tag="Rv2948c"
/product="P-hydroxybenzoyl-AMP ligase FadD22"
/note="Rv2948c, (MTCY24G1.01), len: 705 aa.
FadD22,p-hydroxybenzoyl-AMP ligase. Highly similar to many
e.g. Q9CD82|ML0134 putative acyl-CoA synthetase from
Mycobacterium leprae (707 aa), fasta scores: opt:
3554,E(): 6.4e-209, (75.9% identity in 705 aa overlap).
Almost identical to G560509|Q50468 PKS002A protein from
Mycobacterium tuberculosis (705 aa), fasta scores: opt:
4647, E(): 0, (99.7% identity in 705 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2948c"
/db_xref="EnsemblGenomes-Tr:CCP45752"
/db_xref="GOA:P9WQ61"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ61"
/protein_id="CCP45752.1"
/translation="MRNGNLAGLLAEQASEAGWYDRPAFYAADVVTHGQIHDGAARLG
EVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTE
PALVVTSDALRDRFQPSRVAEAAELMSEAARVAPGGYEPMGGDALAYATYTSGTTGPP
KAAIHRHADPLTFVDAMCRKALRLTPEDTGLCSARMYFAYGLGNSVWFPLATGGSAVI
NSAPVTPEAAAILSARFGPSVLYGVPNFFARVIDSCSPDSFRSLRCVVSAGEALELGL
AERLMEFFGGIPILDGIGSTEVGQTFVSNRVDEWRLGTLGRVLPPYEIRVVAPDGTTA
GPGVEGDLWVRGPAIAKGYWNRPDSPVANEGWLDTRDRVCIDSDGWVTYRCRADDTEV
IGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATIDGSVMRDL
HRGLLNRLSAFKVPHRFAVVDRLPRTPNGKLVRGALRKQSPTKPIWELSLTEPGSGVR
AQRDDLSASNMTIAGGNDGGATLRERLVALRQERQRLVVDAVCAEAAKMLGEPDPWSV
DQDLAFSELGFDSQMTVTLCKRLAAVTGLRLPETVGWDYGSISGLAQYLEAELAGGHG
RLKSAGPVNSGATGLWAIEEQLNKVEELVAVIADGEKQRVADRLRALLGTIAGSEAGL
GKLIQAASTPDEIFQLIDSELGK"
gene complement(3299971..3300570)
/locus_tag="Rv2949c"
CDS complement(3299971..3300570)
/codon_start=1
/transl_table=11
/locus_tag="Rv2949c"
/product="Chorismate pyruvate lyase"
/note="Rv2949c, (MTCY349.41), len: 199 aa. Chorismate
pyruvate lyase, equivalent to Q9CD83|ML0133 hypothetical
protein from Mycobacterium leprae (210 aa), FASTA scores:
opt: 797, E(): 7.4e-47, (62.55% identity in 195 aa
overlap). Equivalent to AAK47348 from Mycobacterium
tuberculosis strain CDC1551 (212 aa) but shorter 13 aa. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv2949c"
/db_xref="EnsemblGenomes-Tr:CCP45753"
/db_xref="GOA:P9WIC5"
/db_xref="InterPro:IPR002800"
/db_xref="InterPro:IPR028978"
/db_xref="UniProtKB/Swiss-Prot:P9WIC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45753.1"
/translation="MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQI
VKQRIHDVSPKLSEFEQLGQVGVGRVLQRYIILKGRNSEHLFVAAESLIAIDRLPAAI
ITRLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVI
SGGQPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR"
gene complement(3300596..3302455)
/gene="fadD29"
/locus_tag="Rv2950c"
CDS complement(3300596..3302455)
/codon_start=1
/transl_table=11
/gene="fadD29"
/locus_tag="Rv2950c"
/product="Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP
synthetase) (fatty-acid-AMP synthase)"
/note="Rv2950c, (MTCY349.40), len: 619 aa.
fadD29,fatty-acid-AMP synthetase, similar to various
mycobacterial enzymes believed to be involved in
polyketide or fatty acid synthesis. Equivalent (but
shorter 61 aa) to Q9CD84 from Mycobacterium leprae (680
aa), FASTA scores: opt: 3280,E(): 2.2e-192, (80.15%
identity in 620 aa overlap); and highly similar to others
from Mycobacterium leprae e.g. Q9Z5K5 probable acyl-CoA
synthase (583 aa), FASTA scores: opt: 2358, E(): 3.4e-136,
(62.35% identity in 579 aa overlap). Also similar to
others from Mycobacterium tuberculosis e.g.
Q10976|FD26_MYCTU putative fatty-acid--CoA ligase (583
aa), FASTA scores: opt: 2416,E(): 1e-139, (63.15% identity
in 581 aa overlap) (N-terminus shorter); etc. Equivalent
to AAK47349 from Mycobacterium tuberculosis strain CDC1551
(582 aa) but longer 37 aa."
/db_xref="EnsemblGenomes-Gn:Rv2950c"
/db_xref="EnsemblGenomes-Tr:CCP45754"
/db_xref="GOA:P95141"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P95141"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45754.1"
/translation="MKTNSSFHAAGEVATQPAWGTGEQAAQPLNGSTSRFAMSESSLA
DLLQKAASQYPNRAAYKFIDYDTDPAGFTETVTWWQVHRRAMIVAEELWIYASSGDRV
AILAPQGLEYIIAFMGVLQAGLIAVPLPVPQFGIHDERISSALRDSAPSIILTTSSVI
DEVTTYAPHACAAQGQSAPIVVAVDALDLSSSRALDPTRFERPSTAYLQYTSGSTRAP
AGVVLSHKNVITNCVQLMSDYIGDSEKVPSTPVSWLPFYHDMGLMLGIILPMINQDTA
VLMSPMAFLQRPARWMQLLAKHRAQISSAPNFGFELAVRRTSDDDMAGLDLGHVRTIV
TGAERVNVATLRRFTERFAPFNLSETAIRPSYGLAEATVYVATAGPGRAPKSVCFDYQ
QLSVGQAKRAENGSEGANLVSYGAPRASTVRIVDPETRMENPAGTVGEIWVQGDNVGL
GYWRNPQQTEATFRARLVTPSPGTSEGPWLRTGDLGVIFEGELFITGRIKELLVVDGA
NHYPEDIEATIQEITGGRVVAIAVPDDRTEKLVTIIELMKRGRTDEEEKNRLRTVKRE
VASAISRSHRLRVADVVMVAPGSIPVTTSGKVRRSASVERYLHHEFSRLDAMA"
gene complement(3303103..3304248)
/locus_tag="Rv2951c"
CDS complement(3303103..3304248)
/codon_start=1
/transl_table=11
/locus_tag="Rv2951c"
/product="Possible oxidoreductase"
/note="Rv2951c, (MTCY349.39), len: 381 aa. Possible
oxidoreductase, equivalent to Q9CD85 putative
oxidoreductase from Mycobacterium leprae (382 aa), FASTA
scores: opt: 2225, E(): 7.6e-134, (84.8% identity in 382
aa overlap); and similar to O30260 conserved hypothetical
protein from Mycobacterium leprae (363 aa), FASTA scores:
opt: 652, E(): 6.1e-34, (32.55% identity in 344 aa
overlap). Also similar to various oxidoreductases e.g.
O29071|AF1196 N5,N10-methylenetetrahydromethanopterin
reductase from Archaeoglobus fulgidus (348 aa), FASTA
scores: opt: 381, E(): 9.7e-17, (27.7% identity in 354 aa
overlap); Q58929|mer|MJ1534 F420-dependent
methylenetetrahydromethanopterin reductase from
Methanococcus jannaschii (331 aa), FASTA scores: opt:
372,E(): 3.5e-16, (30.85% identity in 295 aa overlap);
Q9UXP0 putative F420-dependent
N5,N10-methylene-tetrahydromethanopterin reductase from
Methanolobus tindarius (326 aa), FASTA scores: opt:
343,E(): 2.4e-14, (27.4% identity in 314 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2951c"
/db_xref="EnsemblGenomes-Tr:CCP45755"
/db_xref="GOA:P9WIB7"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/Swiss-Prot:P9WIB7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45755.1"
/translation="MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHL
NALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRN
PAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNS
NGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVR
PSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGV
PGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEV
IDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL"
gene 3304441..3305253
/locus_tag="Rv2952"
CDS 3304441..3305253
/codon_start=1
/transl_table=11
/locus_tag="Rv2952"
/product="Possible methyltransferase (methylase)"
/note="Rv2952, (MTCY349.38), len: 270 aa. Probable
methyltransferase, equivalent to Q9CD86|ML0130
hypothetical protein from Mycobacterium leprae (270 aa),
FASTA scores: opt: 1584, E(): 6.1e-99, (83.7% identity in
270 aa overlap). Also highly similar to Q9RMN9|MTF2
putative methyltransferase from Mycobacterium smegmatis
(274 aa),FASTA scores: opt: 902, E(): 3.8e-53, (56.35%
identity in 252 aa overlap). Also similar to other
methyltransferases e.g. Q9ADL4|SORM O-methyltransferase
from Polyangium cellulosum (346 aa), FASTA scores: opt:
390, E(): 1.1e-18,(36.25% identity in 251 aa overlap);
Q54303|RAPM methyltransferase from Streptomyces
hygroscopicus (317 aa),FASTA scores: opt: 315, E():
1.1e-13, (40.75% identity in 135 aa overlap); etc. Very
similar to C-terminal part of Q50584|Rv1523|MTCY19G5.05c
hypothetical 37.9 KDA protein from Mycobacterium
tuberculosis (358 aa), FASTA score: opt: 965, E():
2.7e-57, (60.3% identity in 247 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2952"
/db_xref="EnsemblGenomes-Tr:CCP45756"
/db_xref="GOA:P9WIN3"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WIN3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45756.1"
/translation="MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDEIVFINW
AYEEDPPMDLPLEASDEPNRAHINLYHRTATQVDLGGKQVLEVSCGHGGGASYLTRTL
HPASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESFDVVLNVEASHCYPH
FRRFLAEVVRVLRPGGYFPYADLRPNNEIAAWEADLAATPLRQLSQRQINAEVLRGIG
NNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD"
gene 3305279..3306535
/locus_tag="Rv2953"
CDS 3305279..3306535
/codon_start=1
/transl_table=11
/locus_tag="Rv2953"
/product="Enoyl reductase"
/note="Rv2953, (MTCY349.37c), len: 418 aa. Enoyl
reductase,equivalent to Q9CD87|ML0129 hypothetical protein
from Mycobacterium leprae (418 aa), FASTA scores: opt:
2357,E(): 2.7e-143, (86.6% identity in 418 aa overlap).
Also highly similar to Q9X7N5|SC5F2A.12c conserved
hypothetical protein from Streptomyces coelicolor (396
aa), FASTA scores: opt: 491, E(): 7e-24, (38.35% identity
in 417 aa overlap); and similar to other hypothetical
proteins e.g. Q9VG81 CG5167 protein from Drosophila
melanogaster (Fruit fly) (431 aa), FASTA scores: opt: 393,
E(): 1.4e-17,(26.55% identity in 433 aa overlap);
Q9GZE9|F22F7.1 hypothetical protein from Caenorhabditis
elegans (426 aa),FASTA scores: opt: 338, E(): 4.6e-14,
(27.05% identity in 425 aa overlap); P73855|SLL1601
hypothetical 44.8 KDA protein from Synechocystis sp.
(strain PCC 6803) (414 aa),FASTA scores: opt: 565, E():
1.3e-28, (35.7% identity in 409 aa overlap); etc. Also
highly similar to other proteins from Mycobacterium
tuberculosis e.g. RV2449C|O53176|MTV008.05C hypothetical
44.4 KDA protein (419 aa), FASTA scores: opt: 1835, E():
7e-110, (67.55% identity in 419 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2953"
/db_xref="EnsemblGenomes-Tr:CCP45757"
/db_xref="GOA:P9WGV5"
/db_xref="InterPro:IPR005097"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGV5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45757.1"
/translation="MSPAEREFDIVLYGATGFSGKLTAEHLAHSGSTARIALAGRSSE
RLRGVRMMLGPNAADWPLILADASQPLTLEAMAARAQVVLTTVGPYTRYGLPLVAACA
KAGTDYADLTGELMFCRNSIDLYHKQAADTGARIILACGFDSIPSDLNVYQLYRRSVE
DGTGELCDTDLVLRSFSQRWVSGGSVATYSEAMRTASSDPEARRLVTDPYTLTTDRGA
EPELGAQPDFLRRPGRDLAPELAGFWTGGFVQAPFNTRIVRRSNALQEWAYGRRFRYS
ETMSLGKSMAAPILAAAVTGTVAGTIGLGNKYFDRLPRRLVERVTPKPGTGPSRKTQE
RGHYTFETYTTTTTGARYRATFAHNVDAYKSTAVLLAQSGLALALDRDRLAELRGVLT
PAAAMGDALLARLPGAGVVMGTTRLS"
gene complement(3306666..3307391)
/locus_tag="Rv2954c"
CDS complement(3306666..3307391)
/codon_start=1
/transl_table=11
/locus_tag="Rv2954c"
/product="Hypothetical protein"
/note="Rv2954c, (MTCY349.36), len: 241 aa. Hypothetical
unknown protein. Equivalent to AAK47354 from Mycobacterium
tuberculosis strain CDC1551 (199 aa) but longer 42 aa.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2954c"
/db_xref="EnsemblGenomes-Tr:CCP45758"
/db_xref="GOA:I6X5U4"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:I6X5U4"
/protein_id="CCP45758.1"
/translation="MRLPGMLRPTAERHFHSIFYLRHNARRQEHLATLGLDLGNKSVL
EVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEA
HQYDVVYCYGVLYHLSRPAEALAWMCDRAVDLLLLETCVSYSGEDEPFLVSERASSPS
QAITGTGCRPSRVWVMNRLREKMPHVYVTATQPRHRQFPLDWRANGPIASTGLARAVF
VASRAPLNLPTLVEELPMVQRRC"
gene complement(3307580..3308545)
/locus_tag="Rv2955c"
CDS complement(3307580..3308545)
/codon_start=1
/transl_table=11
/locus_tag="Rv2955c"
/product="Conserved protein"
/note="Rv2955c, (MTCY349.34), len: 321 aa. Conserved
protein, similar to others e.g. Q98NV5|MLL9724
hypothetical protein from Rhizobium loti (Mesorhizobium
loti) (284 aa),FASTA scores: opt: 231, E(): 6.5e-08,
(34.6% identity in 182 aa overlap); Q9AGG2|NLPE1 NLPE1
from Rhizobium etli (249 aa), FASTA scores: opt: 212, E():
1.1e-06, (27.85% identity in 255 aa overlap); Q9KXY2
hypothetical 31.3 KDA protein from Streptomyces
coelicolor(291 aa), FASTA scores: opt: 211, E(): 1.4e-06,
(30.9% identity in 249 aa overlap); etc. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2955c"
/db_xref="EnsemblGenomes-Tr:CCP45759"
/db_xref="GOA:P95137"
/db_xref="InterPro:IPR006342"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:P95137"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45759.1"
/translation="MQFQDVRLMRVVVCRRLGPAKGQRRWRPLDLGTTGCFENLGAQR
PTYRMRAIRMLECAMPNRLVRSLQRWRPFGLPPHRWRLAPWYWRGLQVTLEPGSAIAW
IVRLTGGFEETEIDIAAALYSALYPDRCILDVGANVGIHSLAWARLAPVVALEPAPGT
HSRLEANVAANGLQDRIRTLRTAAGDAVGEVDFFVAADSAFSSLNDTGRIRIRERTRV
PCTTLDALAAELPLPVGLLKIDVEGLERAVIAGAAELLRRDRPVLLVEIYGGAASNPD
PERTIADIRAYGYEPFVYADDAGLQPYQRHRDDRYCYFFIPSRKG"
gene 3308668..3309399
/locus_tag="Rv2956"
CDS 3308668..3309399
/codon_start=1
/transl_table=11
/locus_tag="Rv2956"
/product="Conserved protein"
/note="Rv2956, (MTCY349.33c), len: 243 aa. Conserved
protein, highly similar to O86299|GSC GSC protein from
Mycobacterium avium subsp. silvaticum Mycobacterium avium
(240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5%
identity in 240 aa overlap); and O86294|GSC GSC protein
from Mycobacterium paratuberculosis (240 aa), FASTA
scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa
overlap). Also some similarity with other proteins from
other organisms e.g. Q9L727 nodulation protein NOEI from
Rhizobium fredii (Sinorhizobium fredii) (241 aa), FASTA
scores: opt: 205, E(): 3.5e-06, (27.25% identity in 198 aa
overlap); Q9AGG1|LPEA LPEA protein from Rhizobium etli
(286 aa), FASTA scores: opt: 201, E(): 7.2e-06, (28.85%
identity in 208 aa overlap); P74191|SLL1173 hypothetical
28.0 KDA protein Synechocystis sp. (strain PCC 6803) (244
aa), FASTA scores: opt: 274, E(): 1e-10, (30.65% identity
in 225 aa overlap); etc. Also highly similar to others
from Mycobacterium tuberculosis e.g.
P71792|RV1513|MTCY277.35 hypothetical 26.7 KDA protein
(243 aa), FASTA scores: opt: 1105, E(): 1.7e-65, (70.05%
identity in 237 aa overlap); etc. Predicted to be an outer
membrane protein (See Song et al., 2008). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2956"
/db_xref="EnsemblGenomes-Tr:CCP45760"
/db_xref="GOA:I6Y242"
/db_xref="InterPro:IPR006342"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:I6Y242"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45760.1"
/translation="MKSLKLARFIARSAAFEVSRRYSERDLKHQFVKQLKSRRVDVVF
DVGANSGQYAAGLRRAAYKGRIVSFEPLSGPFTILESKASTDPLWDCRQHALGDSDGT
VTINIAGNAGQSSSVLPMLKSHQNAFPPANYVGTQEASIHRLDSVAPEFLGMNGVAFL
KVDVQGFEKQVLAGGKSTIDDHCVGMQLELSFLPLYEGGMLIPEALDLVYSLGFTLTG
LLPCFIDANNGRMLQADGIFFREDD"
gene 3309470..3310297
/locus_tag="Rv2957"
CDS 3309470..3310297
/codon_start=1
/transl_table=11
/locus_tag="Rv2957"
/product="Possible glycosyl transferase"
/note="Rv2957, (MTCY349.31c), len: 275 aa. Possible
glycosyl transferase ; possibly secreted protein. Highly
similar to O88109|GSD|GTFD GSD protein from Mycobacterium
avium subsp. silvaticum, Mycobacterium
paratuberculosis,and Mycobacterium avium (266 aa), FASTA
scores: opt: 1010,E(): 2.5e-62, (68.8% identity in 221 aa
overlap). Also some similarity with other proteins and
especially glycosyl transferases e.g. Q9AEE4 hypothetical
31.4 KDA protein from Leptospira interrogans (265 aa),
FASTA scores: opt: 371,E(): 3.3e-18, (34.43% identity in
212 aa overlap); Q9EXY4 putative glycosyl transferase from
Escherichia coli (248 aa), FASTA scores: opt: 339, E():
5e-16, (32.4% identity in 210 aa overlap); Q9RCC4
glycosyltransferase-like protein from Yersinia pestis (247
aa), FASTA scores: opt: 333, E(): 1.3e-15, (31.8% identity
in 217 aa overlap); Q9EXY1 putative glycosyl transferase
from Escherichia coli (248 aa), FASTA scores: opt: 328,
E(): 2.9e-15, (31.9% identity in 210 aa overlap); etc.
Equivalent to AAK47357 from Mycobacterium tuberculosis
strain CDC1551 (256 aa) but longer 19 aa. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2957"
/db_xref="EnsemblGenomes-Tr:CCP45761"
/db_xref="GOA:P9WMX7"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WMX7"
/protein_id="CCP45761.1"
/translation="MVQTKRYAGLTAANTKKVAMAAPMFSIIIPTLNVAAVLPACLDS
IARQTCGDFELVLVDGGSTDETLDIANIFAPNLGERLIIHRDTDQGVYDAMNRGVDLA
TGTWLLFLGADDSLYEADTLARVAAFIGEHEPSDLVYGDVIMRSTNFRWGGAFDLDRL
LFKRNICHQAIFYRRGLFGTIGPYNLRYRVLADWDFNIRCFSNPALVTRYMHVVVASY
NEFGGLSNTIVDKEFLKRLPMSTRLGIRLVIVLVRRWPKVISRAMVMRTVISWRRRR"
gene complement(3310714..3312000)
/locus_tag="Rv2958c"
CDS complement(3310714..3312000)
/codon_start=1
/transl_table=11
/locus_tag="Rv2958c"
/product="Possible glycosyl transferase"
/note="Rv2958c, (MTCY349.30), len: 428 aa. Possible
glycosyl transferase (see citation below), highly similar
to Q9CD88|ML0128 putative glycosyl transferase from
Mycobacterium leprae (435 aa), FASTA scores: opt:
2116,E(): 5.8e-126, (75.05% identity in 417 aa overlap);
and Q9CD91|ML0125 putative glycosyl transferase from
Mycobacterium leprae (438 aa), FASTA scores: opt:
2104,E(): 3.3e-125, (74.65% identity in 418 aa overlap).
Also shows some similarity to variety of glycosyl
transferases e.g. Q9RYI3 putative glycosyltransferase from
Deinococcus radiodurans (418 aa), FASTA scores: opt: 317,
E(): 1.9e-12,(31.0% identity in 297 aa overlap); Q9S1V2
putative glycosyl transferase from Streptomyces coelicolor
(407 aa),FASTA scores: opt: 264, E(): 4.1e-09, (27.2%
identity in 342 aa overlap); P72650|CRTX|SLR1125
zeaxanthin glucosyl transferase from Synechocystis sp.
strain PCC 6803 (419 aa), FASTA scores: opt: 251, E():
2.8e-08, (26.8% identity in 295 aa overlap); etc. Very
similar to P95130|MTCY349.25 from Mycobacterium
tuberculosis (449 aa), FASTA score: opt: 2215, E():
3.3e-132, (77.25% identity in 422 aa overlap). This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2958c"
/db_xref="EnsemblGenomes-Tr:CCP45762"
/db_xref="GOA:P9WFR1"
/db_xref="InterPro:IPR002213"
/db_xref="UniProtKB/Swiss-Prot:P9WFR1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45762.1"
/translation="MEETSVAGDPGPDAGTSTAPNAAPEPVARRQRILFVGEAATLAH
VVRPFVLARSLDPSRYEVHFACDPRFNKLLGPLPFPHHPIHTVPSEEVLLKIAQGRLF
YNTRTLRKYIAADRKILNEIAPDVVVGDNRLSLSVSARLAGIPYIAIANAYWSPQARR
RFPLPDVPWTRFFGVRPVSILYRLYRPLIFALYCLPLNWLRRKHGLSSLGWDLCRIFT
DGDYTLYADVPELVPTYNLPANHRYLGPVLWSPDVKPPTWWHSLPTDRPIIYATLGSS
GGKNLLQVVLNALADLPVTVIAATAGRNHLKNVPANAFVADYLPGEAAAARSAVVLCN
GGSPTTQQALAAGVPVIGLPSNMDQHLNMEALERAGAGVLLRTERLNTEGVAAAVKQV
LSGAEFRQAARRLAEAFGPDFAGFPQHIESALRLVC"
gene complement(3312101..3312838)
/locus_tag="Rv2959c"
CDS complement(3312101..3312838)
/codon_start=1
/transl_table=11
/locus_tag="Rv2959c"
/product="Possible methyltransferase (methylase)"
/note="Rv2959c, (MTCY349.29), len: 245 aa. Possible
methyltransferase, highly similar to Q9CD89|ML0127 from
Mycobacterium leprae (229 aa), FASTA scores: opt:
1183,E(): 3.9e-69, (76.1% identity in 226 aa overlap).
Also some similarity with other methyltransferases and
other proteins e.g. Q51079 putative methyl transferase
from Nocardia lactamdurans (236 aa), FASTA scores: opt:
156, E(): 0.0086,(23.25% identity in 159 aa overlap);
Q98ID5 cephalosporin hydroxylase from Rhizobium loti
(Mesorhizobium loti) (217 aa), FASTA scores: opt: 275,
E(): 1.7e-10, (29.65% identity in 199 aa overlap); etc.
And also similar to P72897 hypothetical 27.8 KDA protein
from Mycobacterium tuberculosis (249 aa), FASTA scores:
opt: 292, E(): 1.5e-11, (31.25% identity in 208 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2959c"
/db_xref="EnsemblGenomes-Tr:CCP45763"
/db_xref="GOA:P9WIM5"
/db_xref="InterPro:IPR007072"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WIM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45763.1"
/translation="MGLVWRSRTSLVGQLIGLVRLVASFAAQLFYRPSDAVAEEYHKW
YYGNLVWTKTTYMGINCWKSVSDMWNYQEILSELQPSLVIEFGTRYGGSAVYFANIMR
QIGQPFKVLTVDNSHKALDPRARREPDVLFVESSSTDPAIAEQIQRLKNEYPGKIFAI
LDSDHSMNHVLAEMKLLRPLLSAGDYLVVEDSNINGHPVLPGFGPGPYEAIEAYEDEF
PNDYKHDAERENKFGWTSAPNGFLIRN"
gene complement(3312953..3313201)
/locus_tag="Rv2960c"
CDS complement(3312953..3313201)
/codon_start=1
/transl_table=11
/locus_tag="Rv2960c"
/product="Hypothetical protein"
/note="Rv2960c, (MT3036, MTCY349.28), len: 82 aa.
Hypothetical unknown protein, equivalent to AAK47362 from
Mycobacterium tuberculosis strain CDC1551 (116 aa) but
shorter 34 aa. Shortened version of MTCY349.28 avoiding
overlap. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2960c"
/db_xref="EnsemblGenomes-Tr:CCP45764"
/db_xref="UniProtKB/TrEMBL:P95133"
/protein_id="CCP45764.1"
/translation="MGRNATAVVSLPVVALSPRAGQAGYLWQSITRGLRVTPICCYHP
PCGGGVQKMLSRKLGRVCPAPSPKDAARGAHNVGANAV"
gene 3313283..3313672
/locus_tag="Rv2961"
CDS 3313283..3313672
/codon_start=1
/transl_table=11
/locus_tag="Rv2961"
/product="Probable transposase"
/note="Rv2961, (MTCY349.26c), len: 129 aa. Probable
transposase, highly similar to C-terminus of
O50414|Rv3387|MTV004.45 putative transposase from
Mycobacterium tuberculosis (225 aa), FASTA scores: opt:
605, E(): 7.2e-34, (66.65% identity in 129 aa overlap);
and similar to others e.g. CAC47401 putative partial
transposase for ISRM17 protein from Rhizobium meliloti
(Sinorhizobium meliloti) (174 aa), FASTA scores: opt:
183,E(): 2.6e-05, (30.25% identity in 129 aa overlap);
etc. This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv2961"
/db_xref="EnsemblGenomes-Tr:CCP45765"
/db_xref="GOA:P95131"
/db_xref="InterPro:IPR002559"
/db_xref="UniProtKB/TrEMBL:P95131"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45765.1"
/translation="MEHGNPHDAPQLAPAVERITTRAGRPPGTVTADRGYGEKRVEDD
LHDLGVRTVAIPRKGRPSQARRAEEQRPSFRRTVKWRTGSEGRISTLKRNYGWNRSCI
DGTEGTRIWTRHGILTHNLIKISSLAA"
gene complement(3313773..3315122)
/locus_tag="Rv2962c"
CDS complement(3313773..3315122)
/codon_start=1
/transl_table=11
/locus_tag="Rv2962c"
/product="Possible glycosyl transferase"
/note="Rv2962c, (MTCY349.25), len: 449 aa. Possible
glycosyl transferase (see citation below), highly similar
or identical to Mycobacterium tuberculosis proteins
G560522 U0002JA, G560521 U0002H, G560522 U0002JA, G560519
U0002KA. Equivalent (but longer 21 aa) to Q9CD91 putative
glycosyl transferase from Mycobacterium leprae (438 aa),
FASTA scores: opt: 2229, E(): 1.3e-133, (77.45% identity
in 426 aa overlap); and highly similar to Q9CD88 putative
glycosyl transferase from Mycobacterium leprae (435 aa),
FASTA scores: opt: 2129, E(): 2.7e-127, (74.35% identity
in 425 aa overlap); and others from Mycobacterium leprae.
Also shows some similarity to variety of glycosyl
transferases e.g. Q9RYI3|DRA0329 putative glycosyl
transferase from Deinococcus radiodurans (418 aa), FASTA
scores: opt: 340,E(): 5.5e-14, (31.2% identity in 330 aa
overlap); P72650 zeaxanthin glucosyl transferase from
Synechocystis sp. (strain PCC 6803) (419 aa), FASTA
scores: opt: 244, E(): 6.6e-08, (26.2% identity in 294 aa
overlap); etc. Also highly similar to P95134 hypothetical
46.8 KDA protein from Mycobacterium tuberculosis (428 aa),
FASTA scores: opt: 2215, E(): 9.6e-133, (77.25% identity
in 422 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2962c"
/db_xref="EnsemblGenomes-Tr:CCP45766"
/db_xref="GOA:P9WN09"
/db_xref="InterPro:IPR002213"
/db_xref="UniProtKB/Swiss-Prot:P9WN09"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45766.1"
/translation="MRVSCVYATASRWGGPPVASEVRGDAAISTTPDAAPGLAARRRR
ILFVAEAVTLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLPFRHHAIHTIPSE
RFFGNLTQGRFYAMRTLRKYVEADLRVLDEIAPDLVVGDLRISLSVSARLAGIPYIAI
ANAYWSPYAQRRFPLPDVIWTRLFGVRLVKLLYRLERPLLFALQCMPLNWVRRRHGLS
SLGWNLCRIFTDGDHTLYADVPELMPTYDLPANHEYLGPVLWSPAGKPPTWWDSLPTD
RPIVYATLGTSGGRNLLQLVLNALAELPVTVIAATAGRSDLKTVPANAFVADYLPGEA
AAARSAVVVCNGGSLTTQQALVAGVPVIGVAGNLDQHLNMEAVERAGAGVLLRTERLK
SQRVAGAVMQVISRSEYRQAAARLADAFGRDRVGFPQHVENALRLMPENRPRTWLAS"
gene 3315236..3316456
/locus_tag="Rv2963"
CDS 3315236..3316456
/codon_start=1
/transl_table=11
/locus_tag="Rv2963"
/product="Probable integral membrane protein"
/note="Rv2963, (MTCY349.24c), len: 406 aa. Probable
integral membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv2963"
/db_xref="EnsemblGenomes-Tr:CCP45767"
/db_xref="GOA:I6YET7"
/db_xref="InterPro:IPR005524"
/db_xref="UniProtKB/Swiss-Prot:I6YET7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45767.1"
/translation="MTSTKVEDRVTAAVLGAIGHALALTASMTWEILWALILGFALSA
VVQAVVRRSTIVTLLGDDRPRTLVIATGLGAASSSCSYAAVALARSLFRKGANFTAAM
AFEIGSTNLVVELGIILALLMGWQFTAAEFVGGPIMILVLAVLFRLFVGARLIDAARE
QAERGLAGSMEGHAAMDMSIKREGSFWRRLLSPPGFTSIAHVFVMEWLAILRDLILGL
LIAGAIAAWVPESFWQSFFLANHPAWSAVWGPIIGPIVAIVSFVCSIGNVPLAAVLWN
GGISFGGVIAFIFADLLILPILNIYRKYYGARMMLVLLGTFYASMVVAGYLIELLFGT
TNLIPSQRSATVMTAEISWNYTTWLNVIFLVIAAALVVRFITSGGLPMLRMMGGSPDA
PHDHHDRHDDHLGH"
gene 3316529..3317461
/gene="purU"
/locus_tag="Rv2964"
CDS 3316529..3317461
/codon_start=1
/transl_table=11
/gene="purU"
/locus_tag="Rv2964"
/product="Probable formyltetrahydrofolate deformylase PurU
(formyl-FH(4) hydrolase)"
/note="Rv2964, (MTCY349.23c), len: 310 aa. Probable
purU,formyltetrahydrofolate deformylase, highly similar to
others e.g. Q9RWT1|DR0584 formyltetrahydrofolate
deformylase from Deinococcus radiodurans (298 aa), FASTA
scores: opt: 1005, E(): 4.9e-52, (52.25% identity in 297
aa overlap); Q9K7U4 formyltetrahydrofolate deformylase
from Bacillus halodurans (289 aa), FASTA scores: opt: 982,
E(): 1.1e-50, (51.8% identity in 280 aa overlap);
Q55135|PURU_SYNY3|SLL0070 formyltetrahydrofolate
deformylase from Synechocystis sp. strain PCC 6803 (284
aa), FASTA scores: opt: 839, E(): 2.9e-42, (48.2% identity
in 280 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2964"
/db_xref="EnsemblGenomes-Tr:CCP45768"
/db_xref="GOA:P9WHM3"
/db_xref="InterPro:IPR002376"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR004810"
/db_xref="InterPro:IPR036477"
/db_xref="InterPro:IPR041729"
/db_xref="UniProtKB/Swiss-Prot:P9WHM3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45768.1"
/translation="MGKGSMTAHATPNEPDYPPPPGGPPPPADIGRLLLRCHDRPGII
AAVSTFLARAGANIISLDQHSTAPEGGTFLQRAIFHLPGLTAAVDELQRDFGSTVADK
FGIDYRFAEAAKPKRVAIMASTEDHCLLDLLWRNRRGELEMSVVMVIANHPDLAAHVR
PFGVPFIHIPATRDTRTEAEQRQLQLLSGNVDLVVLARYMQILSPGFLEAIGCPLINI
HHSFLPAFTGAAPYQRARERGVKLIGATAHYVTEVLDEGPIIEQDVVRVDHTHTVDDL
VRVGADVERAVLSRAVLWHCQDRVIVHHNQTIVF"
gene complement(3318330..3318815)
/gene="kdtB"
/gene_synonym="coaD"
/locus_tag="Rv2965c"
CDS complement(3318330..3318815)
/codon_start=1
/transl_table=11
/gene="kdtB"
/gene_synonym="coaD"
/locus_tag="Rv2965c"
/product="Probable phosphopantetheine adenylyltransferase
KdtB (pantetheine-phosphate adenylyltransferase) (PPAT)
(dephospho-CoA pyrophosphorylase)"
/note="Rv2965c, (MTCY349.22), len: 161 aa. Probable kdtB
(alternate gene name: coaD), phosphopantetheine
adenylyltransferase, equivalent to O69466|COAD_MYCLE
phosphopantetheine adenylyltransferase from Mycobacterium
leprae (160 aa), FASTA scores: opt: 881, E():
2.5e-54,(84.1% identity in 157 aa overlap). Also highly
similar to others e.g. Q9ZBR1|COAD_STRCO from Streptomyces
coelicolor (159 aa), FASTA scores: opt: 575, E(): 5.8e-33,
(54.1% identity in 159 aa overlap); Q9WZK0|COAD_THEMA from
Thermotoga maritima (161 aa), FASTA scores: opt: 509, E():
2.4e-28, (50.0% identity in 154 aa overlap);
P23875|COAD_ECOLICOAD|KDTB|B3634|Z5058|ECS4509 from
Escherichia coli strain O157:H7 and K12 (159 aa), FASTA
scores: opt: 459, E(): 7.3e-25, (45.15% identity in 155 aa
overlap); etc. Belongs to the CoaD family."
/db_xref="EnsemblGenomes-Gn:Rv2965c"
/db_xref="EnsemblGenomes-Tr:CCP45769"
/db_xref="GOA:P9WPA5"
/db_xref="InterPro:IPR001980"
/db_xref="InterPro:IPR004821"
/db_xref="InterPro:IPR014729"
/db_xref="PDB:1TFU"
/db_xref="PDB:3LCJ"
/db_xref="PDB:3NBA"
/db_xref="PDB:3NBK"
/db_xref="PDB:3PNB"
/db_xref="PDB:3RBA"
/db_xref="PDB:3RFF"
/db_xref="PDB:3RHS"
/db_xref="PDB:3UC5"
/db_xref="PDB:4E1A"
/db_xref="PDB:4R0N"
/db_xref="PDB:6G6V"
/db_xref="PDB:6G7S"
/db_xref="PDB:6G7T"
/db_xref="PDB:6G7U"
/db_xref="PDB:6G7V"
/db_xref="UniProtKB/Swiss-Prot:P9WPA5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45769.1"
/translation="MTGAVCPGSFDPVTLGHVDIFERAAAQFDEVVVAILVNPAKTGM
FDLDERIAMVKESTTHLPNLRVQVGHGLVVDFVRSCGMTAIVKGLRTGTDFEYELQMA
QMNKHIAGVDTFFVATAPRYSFVSSSLAKEVAMLGGDVSELLPEPVNRRLRDRLNTER
T"
repeat_region complement(3318835..3318889)
/note="55 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene complement(3318901..3319467)
/locus_tag="Rv2966c"
CDS complement(3318901..3319467)
/codon_start=1
/transl_table=11
/locus_tag="Rv2966c"
/product="Possible methyltransferase (methylase)"
/note="Rv2966c, (MTCY349.21), len: 188 aa. Possible
methyltransferase, equivalent (but shorter 36 aa) to
O69465|MLCB1243.09 hypothetical 23.0 KDA protein from
Mycobacterium leprae (220 aa), FASTA scores: opt: 872,
E(): 9.1e-50, (74.2% identity in 182 aa overlap). Also
similar to others e.g. Q9ZBR2|SC7A1.11 putative methylase
from Streptomyces coelicolor (195 aa), FASTA scores: opt:
510,E(): 3.7e-26, (47.5% identity in 179 aa overlap);
Q9F842 hypothetical methyltransferase (fragment) from
Mycobacterium smegmatis (80 aa), FASTA scores: opt:
386,E(): 2.5e-18, (75.0% identity in 80 aa overlap);
P10120|YHHF_ECOLI|YHHFZ|B3465 putative methylase from
Escherichia colistrain K12 (198 aa), FASTA scores: opt:
319, E(): 1.1e-13, (35.5% identity in 183 aa overlap);
etc. Contains PS00092 N-6 Adenine-specific DNA methylases
signature."
/db_xref="EnsemblGenomes-Gn:Rv2966c"
/db_xref="EnsemblGenomes-Tr:CCP45770"
/db_xref="GOA:I6XFS7"
/db_xref="InterPro:IPR002052"
/db_xref="InterPro:IPR004398"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:6AIE"
/db_xref="UniProtKB/TrEMBL:I6XFS7"
/inference="protein motif:PROSITE:PS00092"
/protein_id="CCP45770.1"
/translation="MTRIIGGVAGGRRIAVPPRGTRPTTDRVRESLFNIVTARRDLTG
LAVLDLYAGSGALGLEALSRGAASVLFVESDQRSAAVIARNIEALGLSGATLRRGAVA
AVVAAGTTSPVDLVLADPPYNVDSADVDAILAALGTNGWTREGTVAVVERATTCAPLT
WPEGWRRWPQRVYGDTRLELAERLFANV"
repeat_region complement(3319468..3319568)
/note="101 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
repeat_region complement(3319569..3319666)
/note="98 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene complement(3319663..3323046)
/gene="pca"
/locus_tag="Rv2967c"
CDS complement(3319663..3323046)
/codon_start=1
/transl_table=11
/gene="pca"
/locus_tag="Rv2967c"
/product="Probable pyruvate carboxylase Pca (pyruvic
carboxylase)"
/note="Rv2967c, (MTCY349.20), len: 1127 aa. Probable
pca,pyruvate carboxylase (ala-rich protein), equivalent to
Q9F843|PYC pyruvate carboxylase from Mycobacterium
smegmatis (1127 aa), FASTA scores: opt: 6232, E():
0,(83.3% identity in 1127 aa overlap). Also highly similar
to others e.g. Q9RK64|SCF11.26c pyruvate carboxylase from
Streptomyces coelicolor (1124 aa), FASTA scores: opt:
5526,E(): 0, (74.65% identity in 1125 aa overlap);
O54587|PYC pyruvate carboxylase from Corynebacterium
glutamicum (Brevibacterium flavum) (1140 aa), FASTA
scores: opt: 4811,E(): 0, (64.5% identity in 1132 aa
overlap); Q9DDT1 pyruvate carboxylase from Brachydanio
rerio (Zebrafish) (1180 aa), FASTA scores: opt: 3133, E():
1.1e-171, (47.8% identity in 1142 aa overlap); etc.
Contains PS00867 Carbamoyl-phosphate synthase subdomain
signature 2, PS00165 Serine/threonine dehydratases
pyridoxal-phosphate attachment site, and PS00188
Biotin-requiring enzymes attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2967c"
/db_xref="EnsemblGenomes-Tr:CCP45771"
/db_xref="GOA:I6YEU0"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR000891"
/db_xref="InterPro:IPR001882"
/db_xref="InterPro:IPR003379"
/db_xref="InterPro:IPR005479"
/db_xref="InterPro:IPR005481"
/db_xref="InterPro:IPR005482"
/db_xref="InterPro:IPR005930"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR011764"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR016185"
/db_xref="UniProtKB/TrEMBL:I6YEU0"
/inference="protein motif:PROSITE:PS00188"
/inference="protein motif:PROSITE:PS00165"
/inference="protein motif:PROSITE:PS00867"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45771.1"
/translation="MFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRLK
ADESYQIGDIGHPVHAYLSVDEIVATARRAGADAIYPGYGFLSENPDLAAACAAAGIS
FVGPSAEVLELAGNKSRAIAAAREAGLPVLMSSAPSASVDELLSVAAGMPFPLFVKAV
AGGGGRGMRRVGDIAALPEAIEAASREAESAFGDPTVYLEQAVINPRHIEVQILADNL
GDVIHLYERDCSVQRRHQKVIELAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEF
LLDERGEYVFIEMNPRVQVEHTVTEEITDVDLVASQLRIAAGETLEQLGLRQEDIAPH
GAALQCRITTEDPANGFRPDTGRISALRTAGGAGVRLDGSTNLGAEISPYFDSMLVKL
TCRGRDLPTAVSRARRAIAEFRIRGVSTNIPFLQAVLDDPDFRAGRVTTSFIDERPQL
LTARASADRGTKILNFLADVTVNNPYGSRPSTIYPDDKLPDLDLRAAPPAGSKQRLVK
LGPEGFARWLRESAAVGVTDTTFRDAHQSLLATRVRTSGLSRVAPYLARTMPQLLSVE
CWGGATYDVALRFLKEDPWERLATLRAAMPNICLQMLLRGRNTVGYTPYPEIVTSAFV
QEATATGIDIFRIFDALNNIESMRPAIDAVRETGSAIAEVAMCYTGDLTDPGEQLYTL
DYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAQRLVSALRSRFDLPVHLHTHDTPGGQ
LASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVAAAAHTEYDTGLSLSAVCALEPY
WEALRKVYAPFESGLPGPTGRVYHHEIPGGQLSNLRQQAIALGLGDRFEEIEEAYAGA
DRVLGRLVKVTPTSKVVGDLALALVGAGVSADEFASDPARFGIPESVLGFLRGELGDP
PGGWPEPLRTAALAGRGAARPTAQLAADDEIALSSVGAKRQATLNRLLFPSPTKEFNE
HREAYGDTSQLSANQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCIL
NGQLRPVLVRDRSIASAVPAAEKADRGNPGHIAAPFAGVVTVGVCVGERVGAGQTIAT
IEAMKMEAPITAPVAGTVERVAVSDTAQVEGGDLLVVVS"
gene complement(3323071..3323703)
/locus_tag="Rv2968c"
CDS complement(3323071..3323703)
/codon_start=1
/transl_table=11
/locus_tag="Rv2968c"
/product="Probable conserved integral membrane protein"
/note="Rv2968c, (MTCY349.19), len: 210 aa. Probable
conserved integral membrane protein, equivalent to O69464
putative integral membrane protein from Mycobacterium
leprae (214 aa), FASTA scores: opt: 1060, E():
1.4e-58,(71.95% identity in 214 aa overlap). Also highly
similar to others e.g. Q9F844 hypothetical integral
membrane protein from Mycobacterium smegmatis (187 aa),
FASTA scores: opt: 883, E(): 1.2e-47, (62.8% identity in
190 aa overlap); Q9KXP3 putative integral membrane protein
from Streptomyces coelicolor (240 aa), FASTA scores: opt:
503, E(): 4.6e-24,(38.0% identity in 192 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv2968c"
/db_xref="EnsemblGenomes-Tr:CCP45772"
/db_xref="GOA:I6X5W1"
/db_xref="InterPro:IPR012932"
/db_xref="InterPro:IPR038354"
/db_xref="InterPro:IPR041714"
/db_xref="UniProtKB/TrEMBL:I6X5W1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45772.1"
/translation="MVAARPAERSGDPAAVRVPVPSAWWVLIGGVIGLFASMTLTVEK
VRILLDPIYVPSCNVNPIVSCGSVMTTPQASLLGFPNPLLGIAGFTVVVVTGVLAVAK
VPLPRWYWIGLAVGILVGVAFVHWLIFQSLYRIGALCPYCMVVWAVIATLLVVVASIV
FGPMRENRGSQERVGARLLYQWRWSLATLWFTTVFLLIMVRFWDYWSTLI"
gene complement(3323709..3324476)
/locus_tag="Rv2969c"
CDS complement(3323709..3324476)
/codon_start=1
/transl_table=11
/locus_tag="Rv2969c"
/product="Possible conserved membrane or secreted protein"
/note="Rv2969c, (MTCY349.18), len: 255 aa. Possible
conserved membrane or exported protein, equivalent to
Q9CBS4|ML1667 possible conserved membrane protein from
Mycobacterium leprae (264 aa), FASTA scores: opt:
1101,E(): 9.9e-68, (65.9% identity in 258 aa overlap); and
highly similar to O69463 putative transmembrane protein
from Mycobacterium leprae (258 aa), FASTA scores: opt:
1097, E(): 1.8e-67, (65.5% identity in 258 aa overlap).
C-terminus also highly similar to Q9KK65|996A160 exported
protein (fragment) from Mycobacterium avium (85 aa), FASTA
scores: opt: 418, E(): 2e-21, (72.95% identity in 85 aa
overlap). Also weakly similar to membrane or exported
proteins e.g. Q9S2U7|SC4G6.04c putative integral membrane
protein from Streptomyces coelicolor (275 aa), FASTA
scores: opt: 312, E(): 7.6e-14, (28.25% identity in 230 aa
overlap); Q9XAB6|SCC22.22C putative secreted protein from
Streptomyces coelicolor (255 aa), FASTA scores: opt:
181,E(): 6.4e-05, (27.0% identity in 226 aa overlap); etc.
Also some similarity with P72001|PKNE_MYCTU from
Mycobacterium tuberculosis (566 aa), FASTA scores: opt:
264, E(): 2.3e-10, (30.5% identity in 177 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2969c"
/db_xref="EnsemblGenomes-Tr:CCP45773"
/db_xref="GOA:O33272"
/db_xref="InterPro:IPR012336"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:4IHU"
/db_xref="PDB:4JR4"
/db_xref="PDB:4JR6"
/db_xref="PDB:4K6X"
/db_xref="UniProtKB/TrEMBL:O33272"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45773.1"
/translation="MADKSKRPPRFDLKSADGSFGRLVQIGGTTIVVVFAVVLVFYIV
TSRDDKKDGVAGPGDAVRVTSSKLVTQPGTSNPKAVVSFYEDFLCPACGIFERGFGPT
VSKLVDIGAVAADYTMVAILDSASNQHYSSRAAAAAYCVADESIEAFRRFHAALFSKD
IQPAELGKDFPDNARLIELAREAGVVGKVPDCINSGKYIEKVDGLAAAVNVHATPTVR
VNGTEYEWSTPAALVAKIKEIVGDVPGIDSAAATATS"
gene complement(3324573..3325703)
/gene="lipN"
/locus_tag="Rv2970c"
CDS complement(3324573..3325703)
/codon_start=1
/transl_table=11
/gene="lipN"
/locus_tag="Rv2970c"
/product="Probable lipase/esterase LipN"
/note="Rv2970c, (MTCY349.17), len: 376 aa. Probable
lipN,lipase/esterase, similar to others e.g. Q9AA37|CC0771
putative esterase from Caulobacter crescentus (380
aa),FASTA scores: opt: 822, E(): 8e-46, (42.15% identity
in 318 aa overlap); Q9XDR4 esterase HDE from
petroleum-degrading bacterium HD-1 (317 aa), FASTA scores:
opt: 738, E(): 2e-40, (48.85% identity in 262 aa overlap);
O52270 lipase from Pseudomonas sp. (strain B11-1) (308
aa), FASTA scores: opt: 683, E(): 7.3e-37, (41.3% identity
in 288 aa overlap); etc. Also similar to P71668
hypothetical 34.1 KDA protein from Mycobacterium
tuberculosis (320 aa), FASTA scores: opt: 715, E():
6.3e-39, (42.3% identity in 298 aa overlap). Equivalent to
AAK47374 from Mycobacterium tuberculosis strain CDC1551
(309 aa) but longer 67 aa."
/db_xref="EnsemblGenomes-Gn:Rv2970c"
/db_xref="EnsemblGenomes-Tr:CCP45774"
/db_xref="GOA:P95125"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P95125"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45774.1"
/translation="MTKSLPGVADLRLGANHPRMWTRRVQGTVVNVGVKVLPWIPTPA
KRILSAGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEAMPG
PQIHVDVTDLSIPGPAGEIPARHYRPSGGGATPLLVFYHGGGWTLGDLDTHDALCRLT
CRDADIQVLSIDYRLAPEHPAPAAVEDAYAAFVWAHEHASDEFGALPGRVAVGGDSAG
GNLSAVVCQLARDKARYEGGPTPVLQWLLYPRTDFTAQTRSMGLFGNGFLLTKRDIDW
FHTQYLRDSDVDPADPRLSPLLAESLSGLAPALIAVAGFDPLRDEGESYAKALRAAGT
AVDLRYLGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV"
gene 3325934..3326104
/locus_tag="Rv2970A"
CDS 3325934..3326104
/codon_start=1
/transl_table=11
/locus_tag="Rv2970A"
/product="Conserved hypothetical protein"
/note="Rv2970A, len: 56 aa. Conserved hypothetical
protein,similar to C-terminal part of several
oxidoreductases e.g. Rv2971|Z83018|MTCY349_22 from
Mycobacterium tuberculosis (282 aa), FASTA scores: opt:
158, E(): 3.6e-06, (45.0% identity in 60 aa overlap). May
represent a gene fragment."
/db_xref="EnsemblGenomes-Gn:Rv2970A"
/db_xref="EnsemblGenomes-Tr:CCP45775"
/db_xref="GOA:I6XFT2"
/db_xref="InterPro:IPR018170"
/db_xref="InterPro:IPR036812"
/db_xref="UniProtKB/TrEMBL:I6XFT2"
/protein_id="CCP45775.1"
/translation="MLIRWHIQLGNIVIPKSVNPMRIASNFDAFDFPRSMTEPGLVRI
RKPSISQAGEMT"
gene 3326101..3326949
/locus_tag="Rv2971"
CDS 3326101..3326949
/codon_start=1
/transl_table=11
/locus_tag="Rv2971"
/product="Probable oxidoreductase"
/note="Rv2971, (MTCY349.16c), len: 282 aa. Probable
oxidoreductase, possibly aldo/keto reductase, equivalent
to O69462 putative oxidoreductase from Mycobacterium
leprae (282 aa), FASTA scores: opt: 1495, E(): 4.9e-93,
(82.35% identity in 272 aa overlap). Also similar to
others e.g. Q9KYM9|SC9H11.10C oxidoreductase from
Streptomyces coelicolor (276 aa), FASTA scores: opt: 849,
E(): 1.2e-49,(51.7% identity in 267 aa overlap);
Q9ZBW7|SC4B5.01C putative oxidoreductase from Streptomyces
coelicolor (277 aa), FASTA scores: opt: 847, E(): 1.7e-49,
(49.1% identity in 271 aa overlap);
Q46857|YQHE_ECOLI|YQHE|B3012 hypothetical oxidoreductase
from Escherichia coli strain K12 (275 aa), FASTA scores:
opt: 827, E(): 3.7e-48, (47.45% identity in 276 aa
overlap); etc. Contains PS00063 Aldo/keto reductase family
putative active site signature; and PS00062 Aldo/keto
reductase family signature 2."
/db_xref="EnsemblGenomes-Gn:Rv2971"
/db_xref="EnsemblGenomes-Tr:CCP45776"
/db_xref="GOA:P9WQA5"
/db_xref="InterPro:IPR018170"
/db_xref="InterPro:IPR020471"
/db_xref="InterPro:IPR023210"
/db_xref="InterPro:IPR036812"
/db_xref="PDB:4OTK"
/db_xref="UniProtKB/Swiss-Prot:P9WQA5"
/inference="protein motif:PROSITE:PS00062"
/inference="protein motif:PROSITE:PS00063"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45776.1"
/translation="MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAAL
EIGCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRASLD
RLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLT
FVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGRLLDNPTVTSIASEYVKT
PAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTRVREDP
LTYAGT"
gene complement(3327023..3327736)
/locus_tag="Rv2972c"
CDS complement(3327023..3327736)
/codon_start=1
/transl_table=11
/locus_tag="Rv2972c"
/product="Possible conserved membrane or exported protein"
/note="Rv2972c, (MTCY349.15), len: 237 aa. Possible
conserved membrane or exported protein, equivalent (but
longer 52 aa) to O69461|MLCB1243.02 hypothetical 20.5 KDA
protein from Mycobacterium leprae (180 aa), FASTA scores:
opt: 581, E(): 8.2e-32, (55.75% identity in 174 aa
overlap). Also similar to membrane or exported proteins
e.g. Q9F2P3|SCE41.16C putative lipoprotein from
Streptomyces coelicolor (258 aa), FASTA scores: opt:
498,E(): 4.1e-26, (44.08% identity in 186 aa overlap);
Q99QB5|SCP1.323C putative secreted protein from
Streptomyces coelicolor (219 aa), FASTA scores: opt:
329,E(): 8.5e-15, (36.35% identity in 176 aa overlap);
Q9ACQ1|SCP1.267 putative secreted protein from
Streptomyces coelicolor (219 aa), FASTA scores: opt: 286,
E(): 6.6e-12,(32.03% identity in 231 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2972c"
/db_xref="EnsemblGenomes-Tr:CCP45777"
/db_xref="InterPro:IPR011089"
/db_xref="UniProtKB/TrEMBL:I6X5W6"
/protein_id="CCP45777.1"
/translation="MNRRTLLWLSAIAALALVVAYQTLGSSAGRHADEFAARAGVPTV
QPGADVLAGIAVLPKRIHRYDYRRSAFGHPWDDRNDAPGGHNGCDTRDDILDRDLVDK
TYVSIKRCPNAVATGTLRDPYTNTTVAFQRGASVGQSVQIDHIVPLSYAWDMGAYRWP
NSERMRFANDPANLLAVQGQANQDKGDSPPAQWMPPNKAFACQYAMQFIAVLRGYSLP
VDQPSSDVLRQAAATCPTG"
gene complement(3327733..3329946)
/gene="recG"
/locus_tag="Rv2973c"
CDS complement(3327733..3329946)
/codon_start=1
/transl_table=11
/gene="recG"
/locus_tag="Rv2973c"
/product="Probable ATP-dependent DNA helicase RecG"
/note="Rv2973c, (MTCY349.14), len: 737 aa. Probable
recG,ATP-dependent DNA helicase (see citation below),
equivalent to O69460|RECG_MYCLE ATP-dependent DNA helicase
from Mycobacterium leprae (743 aa), FASTA scores: opt:
3846,E(): 0, (79.3% identity in 744 aa overlap). Also
highly similar to others e.g. Q9ZBR3|SC7A1.10 putative
ATP-dependent DNA helicase from Streptomyces coelicolor
(742 aa), FASTA scores: opt: 1249, E(): 1.1e-67, (46.2%
identity in 758 aa overlap); Q9PGE8 ATP-dependent DNA
helicase from Xylella fastidiosa (718 aa), FASTA scores:
opt: 1174, E(): 3.5e-63, (42.1% identity in 539 aa
overlap); P24230|RECG_ECOLI|RECG|B3652 from Escherichia
coli strain K12 (693 aa), FASTA scores: opt: 457, E():
7.3e-22, (35.2% identity in 733 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the helicase family, RECG subfamily."
/db_xref="EnsemblGenomes-Gn:Rv2973c"
/db_xref="EnsemblGenomes-Tr:CCP45778"
/db_xref="GOA:P9WMQ7"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR004609"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR033454"
/db_xref="UniProtKB/Swiss-Prot:P9WMQ7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45778.1"
/translation="MASLSDRLDRVLGATAADALDEQFGMRTVDDLLRHYPRSYVEGA
ARVGIGDARPEAGEHITIVDVITDTYSFPMKKKPNRKCLRITVGGGRNKVTATFFNAD
YIMRDLTKHTKVMLSGEVGYYKGAMQLTHPAFLILDSPDGKNHGTRSLKSIADASKAI
SGELVVEEFERRFFPIYPASTKVQSWDIFKCVRQVLDVLDRVDDPLPAELRAKHGLIP
EDEALRAIHLAESQSLRERARERLTFDEAVGLQWALVARRHGELSESGPSAAWKSNGL
AAELLRRLPFELTAGQREVLDVLSDGLAANRPLNRLLQGEVGSGKTIVAVLAMLQMVD
AGYQCALLAPTEVLAAQHLRSIRDVLGPLAMGGQLGGAENATRVALLTGSMTAGQKKQ
VRAEIASGQVGIVIGTHALLQEAVDFHNLGMVVVDEQHRFGVEQRDQLRAKAPAGITP
HLLVMTATPIPRTVALTVYGDLETSTLRELPLGRQPIATNVIFVKDKPAWLDRAWRRI
IEEAAAGRQAYVVAPRIDESDDTDVQGGVRPSATAEGLFSRLRSAELAELRLALMHGR
LSADDKDAAMAAFRAGEVDVLVCTTVIEVGVDVPNATVMLVMDADRFGISQLHQLRGR
IGRGEHPSVCLLASWVPPDTPAGQRLRAVAGTMDGFALADLDLKERKEGDVLGRNQSG
KAITLRLLSLAEHEEYIVAARDFCIEAYKNPTDPALALMAARFTSTDRIEYLDKS"
gene complement(3329949..3331361)
/locus_tag="Rv2974c"
CDS complement(3329949..3331361)
/codon_start=1
/transl_table=11
/locus_tag="Rv2974c"
/product="Conserved hypothetical alanine rich protein"
/note="Rv2974c, (MTCY349.13), len: 470 aa. Conserved
hypothetical ala-rich protein, highly similar to others
e.g. C-terminus of Q9ZBR4|SC7A1.09 hypothetical 59.5 KDA
protein from Streptomyces coelicolor (589 aa), FASTA
scores: opt: 774, E(): 1.3e-36, (41.0% identity in 495 aa
overlap); Q9K9Z6|BH2498 hypothetical protein from Bacillus
halodurans (557 aa), FASTA scores: opt: 268, E():
8e-08,(27.7% identity in 502 aa overlap) (N-terminus
longer 76 aa); Q9X293 conserved hypothetical protein from
Thermotoga maritima (497 aa), FASTA scores: opt: 265, E():
1.1e-07,(24.9% identity in 470 aa overlap) (N-terminus
longer 43 aa); etc. Also some similarity with
P47609|Y369_MYCGE|MG369 hypothetical protein from
Mycoplasma genitalium (557 aa),FASTA scores: opt: 154,
E(): 0.25, (20.25% identity in 489 aa overlap); this, and
following ORF, are similar to Y369_MYCGE but no cosmid
sequence error was identified."
/db_xref="EnsemblGenomes-Gn:Rv2974c"
/db_xref="EnsemblGenomes-Tr:CCP45779"
/db_xref="GOA:I6Y259"
/db_xref="InterPro:IPR004007"
/db_xref="InterPro:IPR019986"
/db_xref="InterPro:IPR033470"
/db_xref="InterPro:IPR036117"
/db_xref="UniProtKB/TrEMBL:I6Y259"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45779.1"
/translation="MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGA
ALWRGVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAHEGLAGAVTAAGDAAVIALEK
TPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEPSPRALPTDTATQRP
APQFEVMYLLAVCDAAAADQLRDRLKELGESVAIAAAPPDSYSVHVHTDDAGAAVEAG
LAVGRVSRIVISALGSGTSGLPAGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPD
AVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTG
SMVQGLAALAVHDAARQAVDDGYSMARAAGASRHGSVRIATQKALTWAGTCKPGDGLG
IAGDEVLIVADDVAAAAIGLVDLLLASGGDLVTVLIGAGVTEDVAVVLERHVHDHHPG
TELVSYRTGHRGDALLIGVE"
gene complement(3331358..3331612)
/locus_tag="Rv2975c"
CDS complement(3331358..3331612)
/codon_start=1
/transl_table=11
/locus_tag="Rv2975c"
/product="Conserved hypothetical protein"
/note="Rv2975c, (MTCY349.12), len: 84 aa. Conserved
hypothetical protein, similar to N-terminus of others e.g.
Q9ZBR4|SC7A1.09 hypothetical 59.5 KDA protein from
Streptomyces coelicolor (589 aa), FASTA scores: opt:
141,E(): 0.0019, (41.25% identity in 80 aa overlap);
Q98R49|MYPU_1610 hypothetical protein from Mycoplasma
pulmonis (545 aa), FASTA scores: opt: 127, E():
0.023,(48.0% identity in 50 aa overlap); Q9K9Z6|BH2498
hypothetical protein from Bacillus halodurans (557
aa),FASTA scores: opt: 126, E(): 0.028, (34.55% identity
in 81 aa overlap); etc. Also some similarity with
N-terminus of P47609|Y369_MYCGE|MG369 hypothetical protein
from Mycoplasma genitalium (557 aa), FASTA scores: opt:
108,E(): 0.7, (36.75% identity in 49 aa overlap); this,
and preceding ORF, are similar to Y369_MYCGE and YLOV
protein but no cosmid sequence error was identified."
/db_xref="EnsemblGenomes-Gn:Rv2975c"
/db_xref="EnsemblGenomes-Tr:CCP45780"
/db_xref="GOA:P95120"
/db_xref="InterPro:IPR004007"
/db_xref="InterPro:IPR036117"
/db_xref="UniProtKB/TrEMBL:P95120"
/protein_id="CCP45780.1"
/translation="MGTADRPLDASALRDWAHAVVSDLILHIDEINRLNVFPVADSDT
GVNMLFTMRAAVVEADLHANSQADAEDVARVAAALAAGAR"
gene complement(3332071..3332754)
/gene="ung"
/locus_tag="Rv2976c"
CDS complement(3332071..3332754)
/codon_start=1
/transl_table=11
/gene="ung"
/locus_tag="Rv2976c"
/product="Probable uracil-DNA glycosylase Ung (UDG)"
/note="Rv2976c, (MTCY349.11), len: 227 aa. Probable
ung,uracil-DNA glycosylase (see citation below),
equivalent to Q9CBS3 uracil-DNA glycosylase from
Mycobacterium leprae (227 aa), FASTA scores: opt: 1394,
E(): 8.8e-85, (88.1% identity in 227 aa overlap). Also
highly similar to others e.g. Q9EX12 from Streptomyces
coelicolor (225 aa), FASTA scores: opt: 1134, E():
1.3e-67, (72.75% identity in 224 aa overlap);
Q9K682|UNG_BACHD from Bacillus halodurans (224 aa), FASTA
scores: opt: 652, E(): 8.9e-36, (45.5% identity in 222 aa
overlap); P39615|UNG_BACSU from Bacillus subtilis (225
aa), FASTA scores: opt: 625, E(): 5.4e-34, (45.5% identity
in 222 aa overlap); etc. Belongs to the uracil-DNA
glycosylase family."
/db_xref="EnsemblGenomes-Gn:Rv2976c"
/db_xref="EnsemblGenomes-Tr:CCP45781"
/db_xref="GOA:P9WFQ9"
/db_xref="InterPro:IPR002043"
/db_xref="InterPro:IPR005122"
/db_xref="InterPro:IPR018085"
/db_xref="InterPro:IPR036895"
/db_xref="PDB:2ZHX"
/db_xref="PDB:3A7N"
/db_xref="PDB:4WPK"
/db_xref="PDB:4WPL"
/db_xref="PDB:4WRU"
/db_xref="PDB:4WRV"
/db_xref="PDB:4WRW"
/db_xref="PDB:4WRX"
/db_xref="PDB:4WRY"
/db_xref="PDB:4WRZ"
/db_xref="PDB:4WS0"
/db_xref="PDB:4WS1"
/db_xref="PDB:4WS2"
/db_xref="PDB:4WS3"
/db_xref="PDB:4WS4"
/db_xref="PDB:4WS5"
/db_xref="PDB:4WS6"
/db_xref="PDB:4WS7"
/db_xref="PDB:4WS8"
/db_xref="UniProtKB/Swiss-Prot:P9WFQ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45781.1"
/translation="MTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLP
AGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIFDEYT
ADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARA
APLVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMG
AEPIDWRLP"
gene complement(3332787..3333788)
/gene="thiL"
/locus_tag="Rv2977c"
CDS complement(3332787..3333788)
/codon_start=1
/transl_table=11
/gene="thiL"
/locus_tag="Rv2977c"
/product="Probable thiamine-monophosphate kinase ThiL
(thiamine-phosphate kinase)"
/note="Rv2977c, (MTCY349.10), len: 333 aa. Possible
thiL,thiamin-monophosphate kinase, equivalent to Q9CBS2
probable thiamine-monophosphate kinase from Mycobacterium
leprae (325 aa), FASTA scores: opt: 1738, E(): 4.5e-98,
(80.9% identity in 314 aa overlap). Also highly similar to
others e.g. Q9ZBR7|SC7A1.06 putative thiamine monphosphate
kinase from Streptomyces coelicolor (322 aa), FASTA
scores: opt: 959, E(): 7.8e-51, (51.1% identity in 319 aa
overlap); O05514|THIL_BACSU thiamine-monophosphate kinase
from Bacillus subtilis (325 aa), FASTA scores: opt: 476,
E(): 1.5e-21, (35.15% identity in 273 aa overlap);
P77785|THIL_ECOLI|THIL|B0417 thiamine-monophosphate kinase
from Escherichia coli strain K12 (325 aa), FASTA scores:
opt: 418, E(): 5e-18, (36.9% identity in 282 aa overlap);
etc. Belongs to the thiamine-monophosphate kinase family.
Note that the start, as given, is in IS1538."
/db_xref="EnsemblGenomes-Gn:Rv2977c"
/db_xref="EnsemblGenomes-Tr:CCP45782"
/db_xref="GOA:P9WG71"
/db_xref="InterPro:IPR006283"
/db_xref="InterPro:IPR010918"
/db_xref="InterPro:IPR016188"
/db_xref="InterPro:IPR036676"
/db_xref="InterPro:IPR036921"
/db_xref="UniProtKB/Swiss-Prot:P9WG71"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45782.1"
/translation="MTTKDHSLATESPTLQQLGEFAVIDRLVRGRRQPATVLLGPGDD
AALVSAGDGRTVVSTDMLVQDSHFRLDWSTPQDVGRKAIAQNAADIEAMGARATAFVV
GFGAPAETPAAQASALVDGMWEEAGRIGAGIVGGDLVSCRQWVVSVTAIGDLDGRAPV
LRSGAKAGSVLAVVGELGRSAAGYALWCNGIEDFAELRRRHLVPQPPYGHGAAAAAVG
AQAMIDVSDGLLADLRHIAEASGVRIDLSAAALAADRDALTAAATALGTDPWPWVLSG
GEDHALVACFVGPVPAGWRTIGRVLDGPARVLVDGEEWTGYAGWQSFGEPDNQGSLG"
mobile_element complement(3333768..3335792)
/mobile_element_type="insertion sequence:IS1538"
/note="IS1538, len: 2025 nt. Similar to other Insertion
sequence elements in M. tuberculosis e.g. IS1535,
IS1536,IS1537, & IS1539 (EM_NEW:MTCY274 Z74024
Mycobacterium tuberculosis cosmid Y274)"
repeat_region 3333768..3333773
/note="6 bp inverted repeat at the left end of
IS1538,TGAGTG"
gene complement(3333785..3335164)
/locus_tag="Rv2978c"
CDS complement(3333785..3335164)
/codon_start=1
/transl_table=11
/locus_tag="Rv2978c"
/product="Probable transposase"
/note="Rv2978c, (MTCY349.09), len: 459 aa. Probable
transposase for IS1538, very similar to several other
putative transposases from Mycobacterium tuberculosis e.g.
YX16_MYCTU|Q10809 (460 aa), FASTA scores: opt: 2613, E():
0, (83.0% identity in 458 aa overlap); etc. Low level
matches to other tranposases."
/db_xref="EnsemblGenomes-Gn:Rv2978c"
/db_xref="EnsemblGenomes-Tr:CCP45783"
/db_xref="InterPro:IPR001959"
/db_xref="InterPro:IPR010095"
/db_xref="InterPro:IPR021027"
/db_xref="UniProtKB/TrEMBL:I6Y263"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45783.1"
/translation="MPKFEVPDGWTVQAFRFTLDPTEDQAKALARHFGARRKAYNWTV
ATLKADIQAWHASGTVTAKPSLRVLRKRWNTVKDDVCVNTETGVAWWPECSKEAYADG
IAGAVEAYWNWQTSRAGKRAGKRVGFPRFKRKGRDQDRVSFTTGAMRVEPDRRHLTLP
VIGTVRTHENTRRIERLIKAGRARVLAISVRRNGTRLDASVRVLVQRPQQPKVVHPGS
RVGVDVGVRRLATVATADGTAIEQVENPRPLGAALRELRHVCRARSRCTKGSRRYRER
TTQISRLHRRVNDVRTHHLHVLTTRLAQTHGRIVVEGLDATEMLRQKGLPGARARRRG
LSDAALGTPRRHLSYKTVWYGSALVVADRWFPSSKTCHACRHVQDIGWDEQWQCDRCS
VVHQRDDCAAINLARYEETSSIVGPVGAAVKRGADRKTGPRPAGGCEARKGSSPKAAE
QPRDGVQVA"
gene complement(3335164..3335748)
/locus_tag="Rv2979c"
CDS complement(3335164..3335748)
/codon_start=1
/transl_table=11
/locus_tag="Rv2979c"
/product="Probable resolvase"
/note="Rv2979c, (MTCY349.08), len: 194 aa. Probable
resolvase for IS1538, with low level matches to transposon
resolvases; highly similar from aa 101 to
YX1C_MYCTU|Q10831 from Mycobacterium tuberculosis (295
aa), FASTA scores: opt: 809, E(): 0, (69.1% identity in
194 aa overlap). Contains PS00397 Site-specific
recombinases active site,and possible helix-turn-helix
motiv at aa 2-23."
/db_xref="EnsemblGenomes-Gn:Rv2979c"
/db_xref="EnsemblGenomes-Tr:CCP45784"
/db_xref="GOA:I6XFU1"
/db_xref="InterPro:IPR006118"
/db_xref="InterPro:IPR006119"
/db_xref="InterPro:IPR036162"
/db_xref="InterPro:IPR041718"
/db_xref="UniProtKB/TrEMBL:I6XFU1"
/inference="protein motif:PROSITE:PS00397"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45784.1"
/translation="MNLATWAERNGVAPGTAYRWFRAGLLSVMARRVGRLILVDEPAG
DAGMRSPTAVYARVSSADQKADLDRQVARVTAWATAQQMPVDKVVTEVGSAFNEHRRK
FLSLLRDPSVHRIVVEHRDRFCRLGSKYVQAAFAAQGRELVVVDSAEVDDDLVRDMTE
ILTSMCARLYGKRAAENRTKRALAAAAGEDHEAA"
repeat_region complement(3335787..3335792)
/note="6 bp inverted repeat at the right end of
IS1538,TGAGTG."
gene 3335960..3336505
/locus_tag="Rv2980"
CDS 3335960..3336505
/codon_start=1
/transl_table=11
/locus_tag="Rv2980"
/product="Possible conserved secreted protein"
/note="Rv2980, (MTCY349.07c), len: 181 aa. Possible
conserved secreted protein, equivalent to Q9CBS1 possible
secreted protein from Mycobacterium leprae (191 aa), FASTA
scores: opt: 794, E(): 2.3e-40, (67.25% identity in 177 aa
overlap). Also some weak similarity with other
hypothetical proteins or secreted proteins e.g. C-terminus
of Q98F98|MLL3872 MLL3872 protein from Rhizobium loti
(Mesorhizobium loti) (575 aa), FASTA scores: opt: 148,
E(): 0.16, (28.35% identity in 194 aa overlap);
Q9L0W9|SCH22A.13C putative secreted protein from
Streptomyces coelicolor (167 aa), FASTA scores: opt:
114,E(): 7.5, (40.0% identity in 80 aa overlap); etc.
Equivalent to AAK47385 from Mycobacterium tuberculosis
strain CDC1551 (214 aa) but shorter 33 aa. Has hydrophobic
stretch near N-terminus. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004). Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2980"
/db_xref="EnsemblGenomes-Tr:CCP45785"
/db_xref="GOA:P95115"
/db_xref="InterPro:IPR021903"
/db_xref="UniProtKB/TrEMBL:P95115"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45785.1"
/translation="MTGESDGPPRAVLIAAAALAAAVIGVILVVAANRQPPERPVVIP
AVPAPQATGPGCKALLAALPQRLGEYRRAPVAEPTTAGATAWRTGPNSTPVILRCGLD
RPAEFVVGSAIQVVDRVQWFQVAAQNPDEPGRSTWYTVDRPVYVALTLPSGSGPTAIQ
ELSDVIDHTIPAVPIDPAPAR"
gene complement(3336796..3337917)
/gene="ddlA"
/gene_synonym="ddl"
/locus_tag="Rv2981c"
CDS complement(3336796..3337917)
/codon_start=1
/transl_table=11
/gene="ddlA"
/gene_synonym="ddl"
/locus_tag="Rv2981c"
/product="Probable D-alanine--D-alanine ligase DdlA
(D-alanylalanine synthetase) (D-ala-D-ala ligase)"
/note="Rv2981c, (MTCY349.06), len: 373 aa. Probable ddlA
(alternate gene name: ddl), D-alanine--D-alanine ligase a
(see citation below), equivalent to Q9CBS0|Q9CBS0
D-alanine-D-alanine ligase a from Mycobacterium leprae
(384 aa), FASTA scores: opt: 2001, E(): 2.4e-115, (81.75%
identity in 367 aa overlap); and Q9ZGN0|DDL_MYCSM
D-alanine--D-alanine ligase from Mycobacterium smegmatis
(373 aa), FASTA scores: opt: 1934, E(): 3.1e-111, (77.95%
identity in 372 aa overlap). Also highly similar to others
e.g. Q9ZBR9|DDL_STRCO from Streptomyces coelicolor (389
aa), FASTA scores: opt: 1187, E(): 2.2e-65, (52.0%
identity in 379 aa overlap); P15051|DDLA_SALTY from
Salmonella typhimurium and Salmonella typhi (363 aa),
FASTA scores: opt: 946, E(): 1.3e-50, (44.5% identity in
364 aa overlap); P23844|DDLA_ECOLI|DDLA|B0381|Z0477|ECS043
1 from Escherichia coli strain O157:H7 and K12 (364 aa),
FASTA scores: opt: 938, E(): 3.9e-50, (43.55% identity in
363 aa overlap); etc. Contains PS00843
D-alanine--D-alanine ligase signature 1. Belongs to the
D-alanine--D-alanine ligase family."
/db_xref="EnsemblGenomes-Gn:Rv2981c"
/db_xref="EnsemblGenomes-Tr:CCP45786"
/db_xref="GOA:P9WP31"
/db_xref="InterPro:IPR000291"
/db_xref="InterPro:IPR005905"
/db_xref="InterPro:IPR011095"
/db_xref="InterPro:IPR011127"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR013815"
/db_xref="InterPro:IPR016185"
/db_xref="PDB:3LWB"
/db_xref="UniProtKB/Swiss-Prot:P9WP31"
/inference="protein motif:PROSITE:PS00843"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45786.1"
/translation="MSANDRRDRRVRVAVVFGGRSNEHAISCVSAGSILRNLDSRRFD
VIAVGITPAGSWVLTDANPDALTITNRELPQVKSGSGTELALPADPRRGGQLVSLPPG
AGEVLESVDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVLASAVGMDKEFTKKLLA
ADGLPVGAYAVLRPPRSTLHRQECERLGLPVFVKPARGGSSIGVSRVSSWDQLPAAVA
RARRHDPKVIVEAAISGRELECGVLEMPDGTLEASTLGEIRVAGVRGREDSFYDFATK
YLDDAAELDVPAKVDDQVAEAIRQLAIRAFAAIDCRGLARVDFFLTDDGPVINEINTM
PGFTTISMYPRMWAASGVDYPTLLATMIETTLARGVGLH"
gene complement(3337995..3338999)
/gene="gpdA2"
/gene_synonym="gpsA"
/locus_tag="Rv2982c"
CDS complement(3337995..3338999)
/codon_start=1
/transl_table=11
/gene="gpdA2"
/gene_synonym="gpsA"
/locus_tag="Rv2982c"
/product="Probable glycerol-3-phosphate dehydrogenase
[NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate
dehydrogenase)"
/note="Rv2982c, (MTCY349.05), len: 334 aa. Probable gpdA2
(alternate gene name: gpsA), glycerol-3-phosphate
dehydrogenase [NAD(P)+], equivalent to Q9CBR9|GPDA_MYCLE
glycerol-3-phosphate dehydrogenase [NAD(P)+] from
Mycobacterium leprae (349 aa), FASTA scores: opt:
1686,E(): 1.7e-95, (77.95% identity in 349 aa overlap).
Also highly similar to others e.g. Q9ZBS0|GPDA_STRCO from
Streptomyces coelicolor (336 aa), FASTA scores: opt:
1165,E(): 9.8e-64, (56.25% identity in 327 aa overlap);
P46919|GPDA_BACSU from Bacillus subtilis (345 aa), FASTA
scores: opt: 872, E(): 7.5e-46, (44.9% identity in 325 aa
overlap); P37606|GPDA_ECOLI|GPSA|B3608|Z5035|ECS4486. from
Escherichia coli strain O157:H7 and K12 (339 aa), FASTA
scores: opt: 799, E(): 2.1e-41, (42.9% identity in 331 aa
overlap); etc. Also highly similar to O53761|GPD2_MYCTU
probable glycerol-3-phosphate dehydrogenase from
Mycobacterium tuberculosis (341 aa), FASTA scores: opt:
740, E(): 8.4e-38, (40.35% identity in 322 aa overlap).
Belongs to the NAD-dependent glycerol-3-phosphate
dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv2982c"
/db_xref="EnsemblGenomes-Tr:CCP45787"
/db_xref="GOA:P9WN77"
/db_xref="InterPro:IPR006109"
/db_xref="InterPro:IPR006168"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR011128"
/db_xref="InterPro:IPR013328"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45787.1"
/translation="MAGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQI
NTTRYNPDYLPGALLPPSIHATADAEEALGGASTVLLGVPAQTMRANLERWAPLLPEG
ATLVSLAKGIELGTLMRMSQVIISVTGAEPPQVAVISGPNLASEIAECQPAATVVACS
DSGRAVALQRALNSGYFRPYTNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAI
ITRGLAEIIRLGTALGANGATLAGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSA
GKACHVVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVDEAITLLLGRRTKPE
"
gene 3339118..3339762
/locus_tag="Rv2983"
CDS 3339118..3339762
/codon_start=1
/transl_table=11
/locus_tag="Rv2983"
/product="Conserved hypothetical alanine rich protein"
/note="Rv2983, (MTCY349.04c), len: 214 aa. Conserved
hypothetical ala-rich protein, equivalent to
O33128|ML1680|MLCB637.37c hypothetical 22.0 KDA protein
from Mycobacterium leprae (216 aa), FASTA scores: opt:
1080, E(): 9e-61, (79.05% identity in 215 aa overlap).
Also similar to other hypothetical proteins e.g.
Q9ZBS2|SC7A1.01C from Streptomyces coelicolor (212
aa),FASTA scores: opt: 420, E(): 2.9e-19, (43.5% identity
in 207 aa overlap); O26710|MTH613 from Methanothermobacter
thermautotrophicus (223 aa), FASTA scores: opt: 193, E():
5.8e-05, (30.0% identity in 190 aa overlap);
Q9RKG8|SCE46.21 from Streptomyces coelicolor (210
aa),FASTA scores: opt: 139, E(): 0.14, (27.65% identity in
206 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2983"
/db_xref="EnsemblGenomes-Tr:CCP45788"
/db_xref="GOA:P9WP83"
/db_xref="InterPro:IPR002835"
/db_xref="InterPro:IPR029044"
/db_xref="PDB:6BWG"
/db_xref="PDB:6BWH"
/db_xref="UniProtKB/Swiss-Prot:P9WP83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45788.1"
/translation="MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLV
DTLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVLADPTPEDDPDPLNTAITAAERV
VAEGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHP
RFGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR"
gene 3339854..3342082
/gene="ppk1"
/locus_tag="Rv2984"
CDS 3339854..3342082
/codon_start=1
/transl_table=11
/gene="ppk1"
/locus_tag="Rv2984"
/product="Polyphosphate kinase PPK (polyphosphoric acid
kinase) (ATP-polyphosphate phosphotransferase)"
/note="Rv2984, (MTCY349.03c), len: 742 aa.
Ppk1,polyphosphate kinase (See Sureka et al., 2007),
equivalent to O33127|PPK_MYCLE polyphosphate kinase from
Mycobacterium leprae (739 aa), FASTA scores: opt: 4264,
E(): 0, (87.85% identity in 742 aa overlap). Also highly
similar to others e.g. Q9KZV6|PPK_STRCO from Streptomyces
coelicolor (746 aa), FASTA scores: opt: 1979, E():
2.6e-117, (59.9% identity in 701 aa overlap);
Q9KD27|PPK_BACHD from Bacillus halodurans (705 aa), FASTA
scores: opt: 1319, E(): 1.4e-75,(45.55% identity in 674 aa
overlap); Q9PAC7|PPK_XYLFA from Xylella fastidiosa (698
aa), FASTA scores: opt: 1300, E(): 2.2e-74, (43.3%
identity in 693 aa overlap); etc. Belongs to the
polyphosphate kinase family."
/db_xref="EnsemblGenomes-Gn:Rv2984"
/db_xref="EnsemblGenomes-Tr:CCP45789"
/db_xref="GOA:P9WHV9"
/db_xref="InterPro:IPR003414"
/db_xref="InterPro:IPR024953"
/db_xref="InterPro:IPR025198"
/db_xref="InterPro:IPR025200"
/db_xref="InterPro:IPR036830"
/db_xref="InterPro:IPR036832"
/db_xref="InterPro:IPR041108"
/db_xref="UniProtKB/Swiss-Prot:P9WHV9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45789.1"
/translation="MMSNDRKVTEIENSPVTEVRPEEHAWYPDDSALAAPPAATPAAI
SDQLPSDRYLNRELSWLDFNARVLALAADKSMPLLERAKFLAIFASNLDEFYMVRVAG
LKRRDEMGLSVRSADGLTPREQLGRIGEQTQQLASRHARVFLDSVLPALGEEGIYIVT
WADLDQAERDRLSTYFNEQVFPVLTPLAVDPAHPFPFVSGLSLNLAVTVRQPEDGTQH
FARVKVPDNVDRFVELAAREASEEAAGTEGRTALRFLPMEELIAAFLPVLFPGMEIVE
HHAFRITRNADFEVEEDRDEDLLQALERELARRRFGSPVRLEIADDMTESMLELLLRE
LDVHPGDVIEVPGLLDLSSLWQIYAVDRPTLKDRTFVPATHPAFAERETPKSIFATLR
EGDVLVHHPYDSFSTSVQRFIEQAAADPNVLAIKQTLYRTSGDSPIVRALIDAAEAGK
QVVALVEIKARFDEQANIAWARALEQAGVHVAYGLVGLKTHCKTALVVRREGPTIRRY
CHVGTGNYNSKTARLYEDVGLLTAAPDIGADLTDLFNSLTGYSRKLSYRNLLVAPHGI
RAGIIDRVEREVAAHRAEGAHNGKGRIRLKMNALVDEQVIDALYRASRAGVRIEVVVR
GICALRPGAQGISENIIVRSILGRFLEHSRILHFRAIDEFWIGSADMMHRNLDRRVEV
MAQVKNPRLTAQLDELFESALDPCTRCWELGPDGQWTASPQEGHSVRDHQESLMERHR
SP"
gene 3342165..3343118
/gene="mutT1"
/locus_tag="Rv2985"
CDS 3342165..3343118
/codon_start=1
/transl_table=11
/gene="mutT1"
/locus_tag="Rv2985"
/product="Possible hydrolase MutT1"
/note="Rv2985, (MTCY349.02c), len: 317 aa. Possible
mutT1,long MutT protein (hydrolase) (see citation below),
highly similar to O33126|MLCB637.35 hypothetical 34.5 KDA
protein from Mycobacterium leprae (312 aa), FASTA scores:
opt: 1514, E(): 5.1e-91, (71.85% identity in 316 aa
overlap); and Q9CBR8|ML1682 hypothetical protein from
Mycobacterium leprae (311 aa), FASTA scores: opt: 1510,
E(): 9.2e-91,(71.5% identity in 316 aa overlap). Also
similar to Q50195|L222-ORF6|ML2698 hypothetical protein
from Mycobacterium leprae (251 aa), FASTA scores: opt:
231, E(): 1.1e-07, (36.7% identity in 128 aa overlap).
Also similar to shorter mutt proteins and related
hypothetical protein e.g. Q9EUS6 hypothetical 16.6 KDA
protein from Streptomyces griseus subsp. griseus (152 aa),
FASTA scores: opt: 380,E(): 1.7e-17, (50.75% identity in
130 aa overlap); Q9KZV8|SCD84.10C putative mutt-like
protein from Streptomyces coelicolor (142 aa), FASTA
scores: opt: 376,E(): 2.9e-17, (46.1% identity in 128 aa
overlap); P96590|mutt mutt protein from Bacillus subtilis
(149 aa),FASTA scores: opt: 180, E(): 0.00017, (35.25%
identity in 122 aa overlap); etc. Also similar to O05437
hypothetical 27.1 KDA protein from Mycobacterium
tuberculosis (248 aa),FASTA scores: opt: 224, E():
3.2e-07, (34.03% identity in 144 aa overlap). Contains
PS00893 mutT domain signature. Seems to belong to the
mutt/NUDIX family protein."
/db_xref="EnsemblGenomes-Gn:Rv2985"
/db_xref="EnsemblGenomes-Tr:CCP45790"
/db_xref="GOA:P9WIY3"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR020084"
/db_xref="InterPro:IPR020476"
/db_xref="InterPro:IPR029033"
/db_xref="UniProtKB/Swiss-Prot:P9WIY3"
/inference="protein motif:PROSITE:PS00893"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45790.1"
/translation="MSIQNSSARRRSAGRIVYAAGAVLWRPGSADSEGPVEIAVIHRP
RYDDWSLPKGKVDPGETAPVGAVREILEETGHRANLGRRLLTVTYPTDSPFRGVKKVH
YWAARSTGGEFTPGSEVDELIWLPVPDAMNKLDYAQDRKVLCRFAKHPADTQTVLVVR
HGTAGSKAHFSGDDSKRPLDKRGRAQAEALVPQLLAFGATDVYAADRVRCHQTMEPLA
AELNVTIHNEPTLTEESYANNPKRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCER
DGVHPDKSRNRKGSTWVLSLSAGRLVTADHIGGALAANVRA"
gene complement(3343176..3343820)
/gene="hupB"
/gene_synonym="hlp"
/gene_synonym="hup"
/gene_synonym="lbp21"
/locus_tag="Rv2986c"
CDS complement(3343176..3343820)
/codon_start=1
/transl_table=11
/gene="hupB"
/gene_synonym="hlp"
/gene_synonym="hup"
/gene_synonym="lbp21"
/locus_tag="Rv2986c"
/product="DNA-binding protein HU homolog HupB
(histone-like protein) (HLP) (21-kDa laminin-2-binding
protein)"
/note="Rv2986c, (MTCY349.01), len: 214 aa. hupB (alternate
gene names: hup, hlp, lbp21), DNA-binding protein HU
homolog (resembles fusion between HU and histone) (see
Pethe et al., 2002), equivalent to others from
Mycobacteria e.g. Q9XB18|DBH_MYCBO from Mycobacterium
bovis (205 aa),FASTA scores: opt: 1050, E(): 5.6e-45,
(95.35% identity in 214 aa overlap); Q9ZHC5|DBH_MYCSM from
Mycobacterium smegmatis (208 aa), FASTA scores: opt: 1035,
E(): 3.1e-44,(80.2% identity in 217 aa overlap); and
O33125|DBH_MYCLE from Mycobacterium leprae (200 aa), FASTA
scores: opt: 914,E(): 2.7e-38, (80.1% identity in 216 aa
overlap). Also highly similar to others from other
organisms e.g. O86537|DBH2_STRCO from Streptomyces
coelicolor (218 aa),FASTA scores: opt: 569, E(): 2.6e-21,
(51.35% identity in 220 aa overlap); P08821|DBH1_BACSU
from Bacillus subtilis (92 aa), FASTA scores: opt: 280,
E(): 2.5e-07, (45.05% identity in 91 aa overlap)
(C-terminus shorter); etc. Contains PS00045 Bacterial
histone-like DNA-binding proteins signature. Belongs to
the bacterial histone-like protein family. Note that its
C-terminal domain is very rich in lysine and alanine."
/db_xref="EnsemblGenomes-Gn:Rv2986c"
/db_xref="EnsemblGenomes-Tr:CCP45791"
/db_xref="GOA:P9WMK7"
/db_xref="InterPro:IPR000119"
/db_xref="InterPro:IPR010992"
/db_xref="InterPro:IPR020816"
/db_xref="PDB:4DKY"
/db_xref="PDB:4PT4"
/db_xref="UniProtKB/Swiss-Prot:P9WMK7"
/inference="protein motif:PROSITE:PS00045"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45791.1"
/translation="MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTI
TGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVVSGAQRLPAEGPAV
KRGVGASAAKKVAKKAPAKKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKA
TKSPAKKVTKAVKKTAVKASVRKAATKAPAKKAAAKRPATKAPAKKATARRGRK"
gene complement(3344033..3344629)
/gene="leuD"
/locus_tag="Rv2987c"
CDS complement(3344033..3344629)
/codon_start=1
/transl_table=11
/gene="leuD"
/locus_tag="Rv2987c"
/product="Probable 3-isopropylmalate dehydratase (small
subunit) LeuD (isopropylmalate isomerase) (alpha-IPM
isomerase) (IPMI)"
/note="Rv2987c, (MTV012.01c), len: 198 aa. Probable
leuD,3-isopropylmalate dehydratase, small subunit,
equivalent to O33124|LEUD_MYCLE 3-isopropylmalate
dehydratase small subunit from Mycobacterium leprae (198
aa), FASTA scores: opt: 1155, E(): 4.2e-72, (87.75%
identity in 196 aa overlap). Also highly similar to many
e.g. O86535|LEUD_STRCO from Streptomyces coelicolor (197
aa),FASTA scores: opt: 765, E(): 2.6e-45, (59.0% identity
in 195 aa overlap); P04787|LEUD_SALTY from Salmonella
typhimurium (201 aa), FASTA scores: opt: 528, E():
5.2e-29,(45.05% identity in 191 aa overlap);
P30126|LEUD_ECOLI|LEUD|B0071 from Escherichia coli strain
K12 (201 aa), FASTA scores: opt: 498, E(): 6e-27, (43.45%
identity in 191 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2987c"
/db_xref="EnsemblGenomes-Tr:CCP45792"
/db_xref="GOA:P9WK95"
/db_xref="InterPro:IPR000573"
/db_xref="InterPro:IPR004431"
/db_xref="InterPro:IPR015928"
/db_xref="InterPro:IPR033940"
/db_xref="PDB:3H5E"
/db_xref="PDB:3H5H"
/db_xref="PDB:3H5J"
/db_xref="UniProtKB/Swiss-Prot:P9WK95"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45792.1"
/translation="MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFA
GWRSDPAFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDIFR
GNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQDRIITAATVVLPFKIDDHSA
WRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP"
gene complement(3344654..3346075)
/gene="leuC"
/locus_tag="Rv2988c"
CDS complement(3344654..3346075)
/codon_start=1
/transl_table=11
/gene="leuC"
/locus_tag="Rv2988c"
/product="Probable 3-isopropylmalate dehydratase (large
subunit) LeuC (isopropylmalate isomerase) (alpha-IPM
isomerase) (IPMI)"
/note="Rv2988c, (MTV012.02c), len: 473 aa. Probable
leuC,3-isopropylmalate dehydratase, large subunit,
equivalent to O33123|LEU2_MYCLE 3-isopropylmalate
dehydratase small subunit from Mycobacterium leprae (476
aa), FASTA scores: opt: 2818, E(): 1.3e-171, (88.75%
identity in 471 aa overlap). Also highly similar to many
e.g. Q44427|LEU2_ACTTI from Actinoplanes teichomyceticus
(485 aa), FASTA scores: opt: 1958, E(): 6.5e-117, (71.0%
identity in 479 aa overlap); P55251|LEU2_RHIPU from
Rhizomucor pusillus (755 aa), FASTA scores: opt: 1937,
E(): 1.9e-115, (61.25% identity in 467 aa overlap)
(C-terminus longer); P30127|LEU2_ECOLI|LEUC|B0072 from
Escherichia coli strain K12 (465 aa), FASTA scores: opt:
1896, E(): 5.5e-113, (61.6% identity in 456 aa overlap);
etc. Contains PS00450 Aconitase family signature. Belongs
to the aconitase/IPM isomerase family."
/db_xref="EnsemblGenomes-Gn:Rv2988c"
/db_xref="EnsemblGenomes-Tr:CCP45793"
/db_xref="GOA:P9WQF5"
/db_xref="InterPro:IPR001030"
/db_xref="InterPro:IPR004430"
/db_xref="InterPro:IPR015931"
/db_xref="InterPro:IPR018136"
/db_xref="InterPro:IPR033941"
/db_xref="InterPro:IPR036008"
/db_xref="UniProtKB/Swiss-Prot:P9WQF5"
/inference="protein motif:PROSITE:PS00450"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45793.1"
/translation="MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTS
PQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGI
RLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVL
ATQTLPLRPFKTMAVNVDGRLPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESL
SMEGRMTICNMSIEAGARAGMVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDV
GAVFDTEVYLDAASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMD
LRPGTAMRDIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQ
AEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAATSNRNFEGRQGAGGRTH
LVSPAVAAATAVRGTLSSPADLN"
gene 3346147..3346848
/locus_tag="Rv2989"
CDS 3346147..3346848
/codon_start=1
/transl_table=11
/locus_tag="Rv2989"
/product="Probable transcriptional regulatory protein"
/note="Rv2989, (MTV012.03), len: 233 aa. Probable
transcriptional regulator (ala-rich protein), highly
similar to O86533|SC1C2.33c putative transcriptional
regulator from Streptomyces coelicolor (238 aa), FASTA
scores: opt: 711, E(): 2.3e-38, (53.05% identity in 230 aa
overlap); and similar to others e.g. Q9KND6 putative
transcriptional regulator from Vibrio cholerae (244
aa),FASTA scores: opt: 232, E(): 1.2e-07, (29.75% identity
in 232 aa overlap); Q9R9U0|SRPS efflux pump regulator from
Pseudomonas putida (259 aa), FASTA scores: opt: 224, E():
4.1e-07, (28.35% identity in 247 aa overlap); etc. Also
similar to proteins from Mycobacterium tuberculosis e.g.
O06806|Rv1773c|MTCY28.39 hypothetical 26.6 KDA protein
(248 aa), FASTA scores: opt: 239, E(): 4.4e-08, (29.85%
identity in 231 aa overlap); P71977|RV1719|MTCY04C12.04
hypothetical 27.9 KDA protein (259 aa), FASTA scores: opt:
215, E(): 1.6e-06, (31.85% identity in 223 aa overlap);
etc. Equivalent to AAK47396 from Mycobacterium
tuberculosis strain CDC1551 (267 aa) but shorter 34 aa.
Contains possible helix-turn-helix motif at aa 25-46
(Score 1005,+2.61 SD)."
/db_xref="EnsemblGenomes-Gn:Rv2989"
/db_xref="EnsemblGenomes-Tr:CCP45794"
/db_xref="GOA:O53238"
/db_xref="InterPro:IPR005471"
/db_xref="InterPro:IPR014757"
/db_xref="InterPro:IPR029016"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:O53238"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45794.1"
/translation="MRQHSGIGVLDKAVGVLHAVAESPCGLAELCDRTDLPRATAYRL
AAALEVHRLLGRGQDGHWRLGPAITELATHVDDPLLVACAAVLPQLRDATGESVQVYR
REGTSRVCVAALEPAAGLRDTVPVGARLPMTAGSGAKVLLAHTDAATQAAVLPKAVFS
ARALAEVCRRGWAQSVAEREPGVASVSAPVRDGRGVVIAAISVSGPIDRMGRRPGVRW
AADLLSAADALTRRL"
gene complement(3346859..3347719)
/locus_tag="Rv2990c"
CDS complement(3346859..3347719)
/codon_start=1
/transl_table=11
/locus_tag="Rv2990c"
/product="Hypothetical protein"
/note="Rv2990c, (MTV012.04c), len: 286 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv2990c"
/db_xref="EnsemblGenomes-Tr:CCP45795"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:I6YEW1"
/protein_id="CCP45795.1"
/translation="MCVTWAEMPKIAALIRHIEDLHARHGRSYILRAGISSLFRYIEG
VHGERPWGTVLDAGTGVKSLQWIQTLPTERWTAVTAARSLADKTRAALGSAMRPQDRL
LVGNWVDDSLLAGETFDTILVDYLVGAIEGFAPYWQDRVFERLRPHLADHGRLYLVGL
EPYVQFEPETESGKIIWEIGRVRDACLLLAGERPYREFPLDWMLGRLGLAGFRILEAR
RFPIRYRARYVNGQLNMCLARIERFSSNGLGMAMRAYVEELRARALQLNERQDGLWHG
NDYVIAVEPM"
gene 3347982..3348473
/locus_tag="Rv2991"
CDS 3347982..3348473
/codon_start=1
/transl_table=11
/locus_tag="Rv2991"
/product="Conserved protein"
/note="Rv2991, (MTV012.05), len: 163 aa. Conserved
protein,similar to others e.g. Q9K3X7|2SCG61.39.
hypothetical 17.6 KDA protein from Streptomyces coelicolor
(153 aa), FASTA scores: opt: 266, E(): 2.1e-11, (34.85%
identity in 155 aa overlap); Q9CNX3|PM0299 hypothetical
protein from Pasteurella multocida (171 aa), FASTA scores:
opt: 175,E(): 5.1e-05, (31.3% identity in 131 aa overlap);
Q9KZI9|SCG8A.10 conserved hypothetical protein from
Streptomyces coelicolor (142 aa), FASTA scores: opt:
163,E(): 0.00031, (32.4% identity in 108 aa overlap); etc.
Also some similarity to O06553|MTCI65.22|Rv1155
hypothetical protein from Mycobacterium tuberculosis (147
aa), FASTA scores: opt: 127, E(): 0.1, (32.9% identity in
73 aa overlap); and to several proteins of similar size
that confer resistance to 5-Nitroimidazole antibiotics in
Bacteroides."
/db_xref="EnsemblGenomes-Gn:Rv2991"
/db_xref="EnsemblGenomes-Tr:CCP45796"
/db_xref="GOA:O53240"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR014419"
/db_xref="InterPro:IPR019920"
/db_xref="PDB:1RFE"
/db_xref="UniProtKB/TrEMBL:O53240"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45796.1"
/translation="MGTKQRADIVMSEAEIADFVNSSRTGTLATIGPDGQPHLTAMWY
AVIDGEIWLETKAKSQKAVNLRRDPRVSFLLEDGDTYDTLRGVSFEGVAEIVEEPEAL
HRVGVSVWERYTGPYTDECKPMVDQMMNKRVGVRIVARRTRSWDHRKLGLPHMSVGGS
TAP"
gene complement(3348547..3348619)
/gene="gluU"
tRNA complement(3348547..3348619)
/gene="gluU"
/product="tRNA-Glu"
/anticodon=(pos:complement(3348583..3348585),aa:Glu,
seq:ctc)
/note="codon recognized: GAG; gluU, tRNA-Glu; anticodon
ctc, length = 73"
gene complement(3348659..3348730)
/gene="glnU"
tRNA complement(3348659..3348730)
/gene="glnU"
/product="tRNA-Gln"
/anticodon=(pos:complement(3348695..3348697),aa:Gln,
seq:ctg)
/note="codon recognized: CAG; glnU, tRNA-Gln; anticodon
ctg, length = 72"
gene complement(3348805..3350277)
/gene="gltS"
/gene_synonym="gltX"
/locus_tag="Rv2992c"
CDS complement(3348805..3350277)
/codon_start=1
/transl_table=11
/gene="gltS"
/gene_synonym="gltX"
/locus_tag="Rv2992c"
/product="Glutamyl-tRNA synthetase GltS (glutamate--tRNA
ligase) (glutamyl-tRNA synthase) (GLURS)"
/note="Rv2992c, (MTV012.06c), len: 490 aa. GltS (alternate
gene name: gltX), glutamyl-tRNA synthase, equivalent to
O33120|SYE_MYCLE glutamyl-tRNA synthetase from
Mycobacterium leprae (502 aa), FASTA scores: opt:
2660,E(): 2.3e-163, (81.35% identity in 488 aa overlap).
Also highly similar to others e.g. O86528|SYE_STRCO from
Streptomyces coelicolor (494 aa), FASTA scores: opt:
1777,E(): 1.4e-106, (57.45% identity in 484 aa overlap);
P22250|SYE_BACSU from Bacillus subtilis (483 aa), FASTA
scores: opt: 1099, E(): 5.4e-63, (38.45% identity in 489
aa overlap); O51345|SYE_BORBU|GLTX|BB0372 from Borrelia
burgdorferi (Lyme disease spirochete) (490 aa), FASTA
scores: opt: 1009, E(): 3.3e-57, (34.85% identity in 491
aa overlap); etc. Belongs to class-I aminoacyl-tRNA
synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv2992c"
/db_xref="EnsemblGenomes-Tr:CCP45797"
/db_xref="GOA:P9WFV9"
/db_xref="InterPro:IPR000924"
/db_xref="InterPro:IPR004527"
/db_xref="InterPro:IPR008925"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR020058"
/db_xref="InterPro:IPR020061"
/db_xref="InterPro:IPR020751"
/db_xref="InterPro:IPR020752"
/db_xref="InterPro:IPR033910"
/db_xref="PDB:2JA2"
/db_xref="PDB:3PNV"
/db_xref="PDB:3PNY"
/db_xref="UniProtKB/Swiss-Prot:P9WFV9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45797.1"
/translation="MTATETVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFR
IEDTDAQRDSEESYLALLDALRWLGLDWDEGPEVGGPYGPYRQSQRAEIYRDVLARLL
AAGEAYHAFSTPEEVEARHVAAGRNPKLGYDNFDRHLTDAQRAAYLAEGRQPVVRLRM
PDDDLAWNDLVRGPVTFAAGSVPDFALTRASGDPLYTLVNPCDDALMKITHVLRGEDL
LPSTPRQLALHQALIRIGVAERIPKFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFI
PEGLLNYLALLGWSIADDHDLFGLDEMVAAFDVADVNSSPARFDQKKADALNAEHIRM
LDVGDFTVRLRDHLDTHGHHIALDEAAFAAAAELVQTRIVVLGDAWELLKFFNDDQYV
IDPKAAAKELGPDGAAVLDAALAALTSVTDWTAPLIEAALKDALIEGLALKPRKAFSP
IRVAATGTTVSPPLFESLELLGRDRSMQRLRAARQLVGHA"
gene complement(3350274..3350993)
/locus_tag="Rv2993c"
CDS complement(3350274..3350993)
/codon_start=1
/transl_table=11
/locus_tag="Rv2993c"
/product="Possible 2-hydroxyhepta-2,4-diene-1,7-dioate
isomerase (HHDD isomerase)"
/note="Rv2993c, (MTV012.07c), len: 239 aa. Possible
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase, equivalent
to O33119|ML1689|MLCB637.28 possible
2-hydroxyhepta-2,4-diene- 1,7-dioate isomerase from
Mycobacterium leprae (242 aa), FASTA scores: opt:
1427,E(): 4.4e-86, (85.9% identity in 241 aa overlap).
Also similar to others e.g. Q9LBE3|DR1609 from Deinococcus
radiodurans (250 aa), FASTA scores: opt: 723, E():
5.5e-40,(49.05% identity in 216 aa overlap);
O27551|MTH1507 from Methanothermobacter thermautotrophicus
(260 aa), FASTA scores: opt: 708, E(): 5.4e-39, (52.1%
identity in 213 aa overlap); Q9HQR6|VNG1037G|HPCE from
Halobacterium sp. (strain NRC-1) (244 aa), FASTA scores:
opt: 590, E(): 2.7e-31, (43.65% identity in 220 aa
overlap); etc. Start chosen by homology, but ORF could
continue upstream."
/db_xref="EnsemblGenomes-Gn:Rv2993c"
/db_xref="EnsemblGenomes-Tr:CCP45798"
/db_xref="GOA:I6Y276"
/db_xref="InterPro:IPR011234"
/db_xref="InterPro:IPR018833"
/db_xref="InterPro:IPR036663"
/db_xref="UniProtKB/TrEMBL:I6Y276"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45798.1"
/translation="MTAREIAEHPFGTPTFTGRSWPLADVRLLAPILASKVVCVGKNY
ADHIAEMGGRPPADPVIFLKPNTAIIGPNTPIRLPANASPVHFEGELAIVIGRACKDV
PAAQAVDNILGYTIGNDVSARDQQQSDGQWTRAKGHDTFCPVGPWIVTDLAPFDPADL
ELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLLPGDLILTGTPAGVGPIEDGDT
VSITIEGIGTLTNPVVRKGKP"
gene 3351269..3352606
/locus_tag="Rv2994"
CDS 3351269..3352606
/codon_start=1
/transl_table=11
/locus_tag="Rv2994"
/product="Probable conserved integral membrane protein"
/note="Rv2994, (MTV012.08), len: 445 aa. Probable
conserved integral membrane protein, member of major
facilitator superfamily (MFS) possibly involved in
transport of drug. C-terminal part highly similar to
O33118|MLCB637.27c hypothetical 14.7 KDA protein (probable
pseudogene product) from Mycobacterium leprae (134 aa),
FASTA scores: opt: 483,E(): 2.7e-21, (60.9% identity in
138 aa overlap). Also similar to various transporters e.g.
Q9I5C8|PA0811 probable MFS transporter from Pseudomonas
aeruginosa (415 aa), FASTA scores: opt: 289, E(): 1.3e-09,
(26.05% identity in 399 aa overlap); O30210|AF0025 cyanate
transport protein from Archaeoglobus fulgidus (393 aa),
FASTA scores: opt: 281,E(): 3.7e-09, (24.05% identity in
399 aa overlap); Q9RI35|SCJ12.25C putative nitrate/nitrite
transporter from Streptomyces coelicolor (412 aa), FASTA
scores: opt: 264,E(): 3.8e-08, (24.95% identity in 409 aa
overlap); Q9A5N5|CC2412 major facilitator family
transporter from Caulobacter crescentus (405 aa), FASTA
scores: opt: 263,E(): 4.3e-08, (27.55% identity in 399 aa
overlap); etc. First start taken; similarity to
P21191|NORA_STAAU quinolone resistance protein from
Staphylococcus aureus (388 aa) suggests alternative start
at 7319 but then no positively charged aa before first
transmembrane segment."
/db_xref="EnsemblGenomes-Gn:Rv2994"
/db_xref="EnsemblGenomes-Tr:CCP45799"
/db_xref="GOA:P9WJW7"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/Swiss-Prot:P9WJW7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45799.1"
/translation="MSRDPTGVGARWAIMIVSLGVTASSFLFINGVAFLIPRLENARG
TPLSHAGLLASMPSWGLVVTMFAWGYLLDHVGERMVMAVGSALTAAAAYAAASVHSLL
WIGVFLFLGGMAAGGCNSAGGRLVSGWFPPQQRGLAMGIRQTAQPLGIASGALVIPEL
AERGVHAGLMFPAVVCTLAAVASVLGIVDPPRKSRTKASEQELASPYRGSSILWRIHA
ASALLMMPQTVTVTFMLVWLINHHGWSVAQAGVLVTISQLLGALGRVAVGRWSDHVGS
RMRPVRLIAAAAAATLFLLAAVDNEGSRYDVLLMIAISVIAVLDNGLEATAITEYAGP
YWSGRALGIQNTTQRLMAAAGPPLFGSLITTAAYPTAWALCGVFPLAAVPLVPVRLLP
PGLETRARRQSVRRHRWWQAVRCHAWPNGPRRPGPPGQPRRVRQGGTAITPPT"
gene complement(3352458..3353468)
/gene="leuB"
/locus_tag="Rv2995c"
CDS complement(3352458..3353468)
/codon_start=1
/transl_table=11
/gene="leuB"
/locus_tag="Rv2995c"
/product="Probable 3-isopropylmalate dehydrogenase LeuB
(beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)"
/note="Rv2995c, (MTV012.09), len: 336 aa. Probable
leuB,3-isopropylmalate dehydrogenase, identical except a
single bp to P94929|LEU3_MYCBO 3-isopropylmalate
dehydrogenase from Mycobacterium bovis (336 aa) (see
citation below),FASTA scores: opt: 2168, E(): 5.1e-132,
(99.7% identity in 336 aa overlap); and equivalent to
O33117|LEU3_MYCLE 3-isopropylmalate dehydrogenase from
Mycobacterium leprae (336 aa), FASTA scores: opt: 1864,
E(): 1.8e-112, (83.95% identity in 336 aa overlap). Also
highly similar to others e.g. P94631|LEU3_CORGL from
Corynebacterium glutamicum (340 aa), FASTA scores: opt:
1526, E(): 1e-90, (69.9% identity in 339 aa overlap);
O86504 from Streptomyces coelicolor (347 aa), FASTA
scores: opt: 1470, E(): 4.2e-87, (67.85% identity in 339
aa overlap); Q9UZ05|PAB2424 from Pyrococcus abyssi (354
aa), FASTA scores: opt: 998, E(): 1e-56, (50.0% identity
in 322 aa overlap); etc. Note that also shows high
similarity with many tartrate dehydrogenases. Belongs to
the isocitrate and isopropylmalate dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv2995c"
/db_xref="EnsemblGenomes-Tr:CCP45800"
/db_xref="GOA:P9WKK9"
/db_xref="InterPro:IPR019818"
/db_xref="InterPro:IPR023698"
/db_xref="InterPro:IPR024084"
/db_xref="PDB:1W0D"
/db_xref="PDB:2G4O"
/db_xref="UniProtKB/Swiss-Prot:P9WKK9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45800.1"
/translation="MKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHA
TGEVLPDSVVAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLY
PGVASPLSGNPGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVA
DAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMI
TDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDI
AGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRGSERLATSDVGERIAA
AL"
gene complement(3353483..3355069)
/gene="serA1"
/gene_synonym="serA"
/locus_tag="Rv2996c"
CDS complement(3353483..3355069)
/codon_start=1
/transl_table=11
/gene="serA1"
/gene_synonym="serA"
/locus_tag="Rv2996c"
/product="Probable D-3-phosphoglycerate dehydrogenase
SerA1 (PGDH)"
/note="Rv2996c, (MTV012.10), len: 528 aa. Probable
serA1,D-3-phosphoglycerate dehydrogenase, equivalent to
SERA_MYCLE D-3-phosphoglycerate dehydrogenase from
Mycobacterium leprae (528 aa), FASTA scores: opt:
2974,E(): 1.9e-166, (89.6% identity in 528 aa overlap).
Also highly similar to many e.g. Q9Z564 from Streptomyces
coelicolor (529 aa), FASTA scores: opt: 1879, E():
2.1e-102, (57.6% identity in 526 aa overlap);
O29445|SERA_ARCFU from Archaeoglobus fulgidus (527
aa),FASTA scores: opt: 1252, E(): 9.6e-66, (41.3% identity
in 530 aa overlap); P35136|SERA_BACSU from Bacillus
subtilis (525 aa), FASTA scores: opt: 1172, E(): 4.5e-61,
(37.9% identity in 528 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop), PS00065 D-isomer
specific 2-hydroxyacid dehydrogenases NAD-binding
signature, and PS00670 D-isomer specific 2-hydroxyacid
dehydrogenases signature 2. Belongs to the D-isomer
specific 2-hydroxyacid dehydrogenases family. Note that
previously known as serA."
/db_xref="EnsemblGenomes-Gn:Rv2996c"
/db_xref="EnsemblGenomes-Tr:CCP45801"
/db_xref="GOA:P9WNX3"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR006139"
/db_xref="InterPro:IPR006140"
/db_xref="InterPro:IPR006236"
/db_xref="InterPro:IPR029009"
/db_xref="InterPro:IPR029752"
/db_xref="InterPro:IPR029753"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:1YGY"
/db_xref="PDB:3DC2"
/db_xref="PDB:3DDN"
/db_xref="UniProtKB/Swiss-Prot:P9WNX3"
/inference="protein motif:PROSITE:PS00670"
/inference="protein motif:PROSITE:PS00065"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45801.1"
/translation="MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEA
DALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSA
AEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRI
AAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEAL
AKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVV
TPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLG
VLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAE
RGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLR
AQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDD
VRTAIAAAVDAYKLEVVDLS"
gene 3355099..3356541
/locus_tag="Rv2997"
CDS 3355099..3356541
/codon_start=1
/transl_table=11
/locus_tag="Rv2997"
/product="Possible alanine rich dehydrogenase"
/note="Rv2997, (MTV012.11), len: 480 aa. Possible ala-rich
dehydrogenase, similar to others dehydrogenases and
hypothetical proteins e.g. Q9EYI5 putative dehydrogenase
from Streptomyces nogalater (472 aa), FASTA scores: opt:
1131, E(): 1.7e-61, (41.0% identity in 471 aa overlap);
Q9ZBG4|SC9B5.16 putative dehydrogenase from Streptomyces
coelicolor (472 aa), FASTA scores: opt: 1064, E():
2e-57,(39.05% identity in 471 aa overlap); Q98BS8 probable
dehydrogenase from Rhizobium loti (Mesorhizobium loti)
(524 aa), FASTA scores: opt: 196, E(): 0.00021, (25.1%
identity in 526 aa overlap); etc. Shows strong similarity
throughout its length to O06826|MTCY493.22c|Rv1432
hypothetical 50.5 KDA protein from Mycobacterium
tuberculosis (473 aa), FASTA scores: opt: 1220, E():
6.1e-67, (42.35% identity in 465 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv2997"
/db_xref="EnsemblGenomes-Tr:CCP45802"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:I6YAU3"
/protein_id="CCP45802.1"
/translation="MDVTVVGSGPNGLATAVICARAGLNVQVVEAQATFGGGARSAAD
FEFPEVLHDVCSAVHPLALASPFFAEFDLPARGVTLTVPDIAYANPLPGRPAAIAYHD
LAHTCAKLDDGASWRRLLGPLVAHSETVVEFMLSDKRSLPTALGSVLRLGLRMLAQGT
PAWRSLAGEDARALFTGVAAHAISPLPSLVSAGAGLMLATLAHSVGWPIPVGGTQAIA
DALIADLRAHGGRLAAGVEITEPQRSVVVFDTAPTALLRVYRDKLPHRYAKALRRYRF
RAGIAKVDFVLSDEIPWSDPRLRRAATLHLGGTRDQMARAEADVAAGRHADWPMVLAA
CPHVADPGRIDETGRRPFWTYAHVPSGSTLDATETVTSVLERFAPGFRDIVVAARAVP
AARMADHNANYVGGDITVGANSTWRAIAGPTPRLNPWRTPIPKVYLCSAATPPGAGVH
GMCGWYAARTLLRTEFGITRMPPLGHELRP"
gene 3356815..3357276
/locus_tag="Rv2998"
CDS 3356815..3357276
/codon_start=1
/transl_table=11
/locus_tag="Rv2998"
/product="Hypothetical protein"
/note="Rv2998, (MTV012.12), len: 153 aa. Hypothetical
unknown protein. Note that equivalent to AAK47405
Hypothetical 19.4 kDa protein from Mycobacterium
tuberculosis strain CDC1551 (186 aa) but sequence differs
in N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv2998"
/db_xref="EnsemblGenomes-Tr:CCP45803"
/db_xref="GOA:O53245"
/db_xref="UniProtKB/TrEMBL:O53245"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45803.1"
/translation="MDVIWSATIATTVATGMRKPRMHGMPPITSGSMVTRVTRMSIRL
AGDSTLGRFSTSRLGLSSAKSKPEGDFGTACGAVSGGDAGVVALAEGVDDGQSKPGAA
GGARGVGGFRESRADCGEQFGVASWTPQGEFEFGGQEAKGVRSSWPASLTN"
gene complement(3357225..3357428)
/locus_tag="Rv2998A"
CDS complement(3357225..3357428)
/codon_start=1
/transl_table=11
/locus_tag="Rv2998A"
/product="Conserved hypothetical protein"
/note="Rv2998A, len: 67 aa. Probable conserved
hypothetical protein, (possibly gene fragment), highly
similar to central part of two-component sensor proteins
e.g. O07777|Rv0601c|MTCY19H5.21 two component sensor
(fragment) from Mycobacterium tuberculosis (156 aa), FASTA
scores: opt: 212, E(): 3.7e-09, (58.2% identity in 67 aa
overlap); Q9L2B6|SC8F4.08 probable two-component sensor
kinase from Streptomyces coelicolor (478 aa), FASTA
scores: opt: 193,E(): 2.6e-07, (47.05% identity in 68 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv2998A"
/db_xref="EnsemblGenomes-Tr:CCP45804"
/db_xref="GOA:Q6MX20"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR036097"
/db_xref="UniProtKB/TrEMBL:Q6MX20"
/protein_id="CCP45804.1"
/translation="MERMRIRAAGISATDPHARLPLPLARDEIRYLGTTFNDLLQRLQ
DALERERQFVSDAGHELRTPLAS"
gene 3357602..3358567
/gene="lppY"
/locus_tag="Rv2999"
CDS 3357602..3358567
/codon_start=1
/transl_table=11
/gene="lppY"
/locus_tag="Rv2999"
/product="Probable conserved lipoprotein LppY"
/note="Rv2999, (MTV012.13), len: 321 aa. Probable
lppY,conserved lipoprotein, highly similar to
O07774|LPQO|Rv0604|MTCY19H5.18c putative lipoprotein from
Mycobacterium tuberculosis (316 aa), FASTA scores: opt:
1153, E(): 5e-62, (53.2% identity in 312 aa overlap); and
showing similarity with AAK80743|CAC2799 uncharacterized
conserved protein similar to LPPY/LPQO of Mycobacterium
tuberculosis from Clostridium acetobutylicum (152
aa),FASTA scores: opt: 165, E(): 0.0077, (26.08% identity
in 138 aa overlap); and Q9F2T1|SCD65.01c putative
lipoprotein (fragment) from Streptomyces coelicolor (146
aa), FASTA scores: opt: 126, E(): 1.6, (% identity in aa
overlap). Equivalent to AAK47407 from Mycobacterium
tuberculosis strain CDC1551 (329 aa) but shorter 8 aa.
Contains probable N-terminal signal sequence and PS00013
Prokaryotic membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2999"
/db_xref="EnsemblGenomes-Tr:CCP45805"
/db_xref="GOA:O53246"
/db_xref="InterPro:IPR011094"
/db_xref="UniProtKB/TrEMBL:O53246"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45805.1"
/translation="MAGAKHAGRIVAITTAAAVILAACSSGSKGGAGSGHAGKARSAV
TTTDADWKPVADALGRSGKLGDNNTAYRINLPRNDLHITSYGVDIKPGLSLGGYAAFA
RYDNNETLLMGDLVITEEELPKVTDALQAHGIAQTALHKHLLQQDPPVWWTHIHGMGD
AARLAQGLKAALDATTIGPPTPPPARQPPVDIDVAGVDQALGRKGTQDGGLMKYSIPR
KDTIIEDGHVLPAVSLNLTTVINFQPVGRGRAAINGDFILIAPEVQEVIRAMRAGNIT
IVELHNHGLTEEPRLFYMHYWAVDDAVTLARALRPAMDATNLQSS"
gene 3358612..3359271
/locus_tag="Rv3000"
CDS 3358612..3359271
/codon_start=1
/transl_table=11
/locus_tag="Rv3000"
/product="Possible conserved transmembrane protein"
/note="Rv3000, (MTV012.14), len: 219 aa. Possible
conserved transmembrane protein, similar to various
membrane proteins e.g. P77307|YBBM_ECOLI|B0491
hypothetical 28.2 KDA protein (potential integral membrane
protein) from Escherichia coli strain K12 (259 aa), FASTA
scores: opt: 292, E(): 3.1e-11,(30.25% identity in 218 aa
overlap); N-terminus of Q9BJF3 putative ABC transporter
(fragment) from Sterkiella histriomuscorum (1319 aa),
FASTA scores: opt: 274, E(): 1.3e-09, (39.6% identity in
101 aa overlap); Q9C9W0|T23K23.21 putative ABC transporter
from Arabidopsis thaliana (Mouse-ear cress) (263 aa),
FASTA scores: opt: 258, E(): 4.4e-09, (30.1% identity in
196 aa overlap); P74369|YG47_SYNY3|SLR1647 hypothetical
28.1 KDA protein (potential integral membrane protein)
from Synechocystis sp. strain PCC 6803 (259 aa), FASTA
scores: opt: 257, E(): 5.1e-09, (37.75% identity in 98 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3000"
/db_xref="EnsemblGenomes-Tr:CCP45806"
/db_xref="GOA:I6X5Z8"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR005226"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:I6X5Z8"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45806.1"
/translation="MAVHGFLLERVSVVRDEATVLRQVSAHFPAGRCSAVRGASGSGK
TTLLRLLNRLIDPTSGKVWLDGVPLTDLDVLVLRRRVGLVAQAPVVLTDAVLNEVRVG
RPDLPEGRVTELLARLCLGQSAREAFLPHQRSALRTALIPAIDSTKVVGLISLPGAMS
GLILAGVDPLTAIRYQIVVMYLLLAATAVAALTCARLAERALFDRAHRLVSLPAATRR
A"
gene complement(3359585..3360586)
/gene="ilvC"
/locus_tag="Rv3001c"
CDS complement(3359585..3360586)
/codon_start=1
/transl_table=11
/gene="ilvC"
/locus_tag="Rv3001c"
/product="Probable KETOL-acid reductoisomerase IlvC
(acetohydroxy-acid isomeroreductase)
(alpha-keto-beta-hydroxylacil reductoisomerase)"
/note="Rv3001c, (MT3081, MTV012.15c), len: 333 aa.
Probable ilvC, ketol-acid reductoisomerase, equivalent or
highly similar to others e.g. Q59500|ILVC_MYCAV from
Mycobacterium avium (333 aa), FASTA scores: opt: 1977,
E(): 3.2e-113,(87.7% identity in 333 aa overlap);
O33114|ILVC_MYCLE from Mycobacterium leprae (333 aa),
FASTA scores: opt: 1924,E(): 5.3e-110, (86.5% identity in
333 aa overlap); Q9Z565|ILVC_STRCO|SC8D9.26 from
Streptomyces coelicolor (332 aa), FASTA scores: opt: 1494,
E(): 8.3e-84, (67.5% identity in 326 aa overlap);
Q59818|ILVC_STRAW from Streptomyces avermitilis (333 aa)
FASTA scores: opt: 1487,E(): 2.2e-83, (66.8% identity in
326 aa overlap); etc. Belongs to the KETOL-acid
reductoisomerases family."
/db_xref="EnsemblGenomes-Gn:Rv3001c"
/db_xref="EnsemblGenomes-Tr:CCP45807"
/db_xref="GOA:P9WKJ7"
/db_xref="InterPro:IPR000506"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR013023"
/db_xref="InterPro:IPR013116"
/db_xref="InterPro:IPR014359"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:4YPO"
/db_xref="UniProtKB/Swiss-Prot:P9WKJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45807.1"
/translation="MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGL
KQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDALF
FGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLA
LALSYAKAIGGTRAGVIKTTFKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPA
ELAYFEVLHELKLIVDLMYEGGLARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDIL
REIQDGSFVHKLVADVEGGNKQLEELRRQNAEHPIEVVGKKLRDLMSWVDRPITETA"
gene complement(3360624..3361130)
/gene="ilvN"
/gene_synonym="ilvH"
/locus_tag="Rv3002c"
CDS complement(3360624..3361130)
/codon_start=1
/transl_table=11
/gene="ilvN"
/gene_synonym="ilvH"
/locus_tag="Rv3002c"
/product="Probable acetolactate synthase (small subunit)
IlvN (acetohydroxy-acid synthase) (AHAS) (ALS)"
/note="Rv3002c, (MT3082, MTV012.16c), len: 168 aa.
Probable ilvN (alternate gene name: ilvH), acetolactate
synthase,small subunit, equivalent or highly similar to
others e.g. O33113|ILVH_MYCLE|MLCB637.21 from
Mycobacterium leprae (169 aa), FASTA scores: opt: 843,
E(): 5.1e-47, (83.5% identity in 164 aa overlap);
Q59499|ILVH_MYCAV|ILVN from Mycobacterium avium (167 aa),
FASTA scores: opt: 798, E(): 3.7e-44, (81.05% identity in
169 aa overlap); Q9Z566|ILVN from Streptomyces coelicolor
(174 aa), FASTA scores: opt: 678, E(): 1.7e-36, (64.8%
identity in 159 aa overlap); etc. Belongs to the
acetolactate synthase small subunit family."
/db_xref="EnsemblGenomes-Gn:Rv3002c"
/db_xref="EnsemblGenomes-Tr:CCP45808"
/db_xref="GOA:P9WKJ3"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR004789"
/db_xref="InterPro:IPR019455"
/db_xref="InterPro:IPR027271"
/db_xref="InterPro:IPR039557"
/db_xref="UniProtKB/Swiss-Prot:P9WKJ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45808.1"
/translation="MSPKTHTLSVLVEDKPGVLARVAALFSRRGFNIESLAVGATECK
DRSRMTIVVSAEDTPLEQITKQLNKLINVIKIVEQDDEHSVSRELALIKVQADAGSRS
QVIEAVNLFRANVIDVSPESLTVEATGNRGKLEALLRVLEPFGIREIAQSGMVSLSRG
PRGIGTAK"
gene complement(3361130..3362986)
/gene="ilvB1"
/gene_synonym="ilvB"
/locus_tag="Rv3003c"
CDS complement(3361130..3362986)
/codon_start=1
/transl_table=11
/gene="ilvB1"
/gene_synonym="ilvB"
/locus_tag="Rv3003c"
/product="Acetolactate synthase (large subunit) IlvB1
(acetohydroxy-acid synthase)"
/note="Rv3003c, (MT3083, MTV012.17c), len: 618 aa.
ilvB1,acetolactate synthase, large subunit, equivalent or
highly similar to others e.g.
O33112|ILVB_MYCLE|MLCB637.20|ML1696 from Mycobacterium
leprae (625 aa), FASTA scores: opt: 3653, E(): 5.4e-208,
(87.1% identity in 627 aa overlap); Q59498|ILVB_MYCAV from
Mycobacterium avium (621 aa), FASTA scores: opt: 3473,
E(): 2.3e-197, (84.7% identity in 614 aa overlap);
P42463|ILVB_CORGL from Corynebacterium glutamicum
(Brevibacterium flavum) (626 aa), FASTA scores: opt:
2754,E(): 5.9e-155, (65.8% identity in 589 aa overlap);
etc. Contains PS00187 Thiamine pyrophosphate enzymes
signature. Cofactor: thiamine pyrophosphate, and magnesium
(by similarity). Note that previously known as ilvB."
/db_xref="EnsemblGenomes-Gn:Rv3003c"
/db_xref="EnsemblGenomes-Tr:CCP45809"
/db_xref="GOA:P9WG41"
/db_xref="InterPro:IPR000399"
/db_xref="InterPro:IPR011766"
/db_xref="InterPro:IPR012000"
/db_xref="InterPro:IPR012001"
/db_xref="InterPro:IPR012846"
/db_xref="InterPro:IPR029035"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR039368"
/db_xref="UniProtKB/Swiss-Prot:P9WG41"
/inference="protein motif:PROSITE:PS00187"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45809.1"
/translation="MSAPTKPHSPTFKPEPHSAANEPKHPAARPKHVALQQLTGAQAV
IRSLEELGVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAHVTGRV
GVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITMPIT
KHNFLVRSGDDIPRVLAEAFHIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMELPGYK
PNTKPHSRQVREAAKLIAAARKPVLYVGGGVIRGEATEQLRELAELTGIPVVTTLMAR
GAFPDSHRQNLGMPGMHGTVAAVAALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIH
ADIDPAEIGKNRHADVPIVGDVKAVITELIAMLRHHHIPGTIEMADWWAYLNGVRKTY
PLSYGPQSDGSLSPEYVIEKLGEIAGPDAVFVAGVGQHQMWAAQFIRYEKPRSWLNSG
GLGTMGFAIPAAMGAKIALPGTEVWAIDGDGCFQMTNQELATCAVEGIPVKVALINNG
NLGMVRQWQSLFYAERYSQTDLATHSHRIPDFVKLAEALGCVGLRCEREEDVVDVINQ
ARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEIQAARGIRPLFDDITEGHA"
gene 3363348..3363686
/gene="cfp6"
/locus_tag="Rv3004"
CDS 3363348..3363686
/codon_start=1
/transl_table=11
/gene="cfp6"
/locus_tag="Rv3004"
/product="Low molecular weight protein antigen 6 (CFP-6)"
/note="Rv3004, (MT3084.1, MTV012.18), len: 112 aa.
Cfp6,low molecular weight protein antigen 6 (CFP-6) (See
Bhaskar et al., 2000). Weak homology with Q9RKZ5|SC6D7.02
putative membrane protein from Streptomyces coelicolor
(156 aa),FASTA scores: opt: 109, E(): 0.78, (39.4%
identity in 122 aa overlap). Caution: the initiator
methionine may be further upstream making the sequence a
precursor. Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3004"
/db_xref="EnsemblGenomes-Tr:CCP45810"
/db_xref="GOA:P9WIR1"
/db_xref="InterPro:IPR019692"
/db_xref="UniProtKB/Swiss-Prot:P9WIR1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45810.1"
/translation="MAHFAVGFLTLGLLVPVLTWPVSAPLLVIPVALSASIIRLRTLA
DERGVTVRTLVGSRAVRWDDIDGLRFHRGSWARATLKDGTELRLPAVTFATLPHLTEA
SSGRVPNPYR"
gene complement(3363693..3364532)
/locus_tag="Rv3005c"
CDS complement(3363693..3364532)
/codon_start=1
/transl_table=11
/locus_tag="Rv3005c"
/product="Conserved hypothetical protein"
/note="Rv3005c, (MTV012.19c), len: 279 aa. Conserved
hypothetical protein, equivalent to
O33110|MLCB637.18|ML1698 hypothetical 29.5 KDA protein
from Mycobacterium leprae (277 aa), FASTA scores: opt:
1245,E(): 1.2e-65, (70.5% identity in 278 aa overlap).
Also similar, but longer approximately 100 aa in
N-terminus, to other hypothetical proteins, few membrane
proteins, e.g. Q9RKN9|SCC75A.35 putative membrane protein
from Streptomyces coelicolor (180 aa), FASTA scores: opt:
326,E(): 3.9e-12, (44.2% identity in 138 aa overlap);
P96694|YDFP|AB001488 hypothetical protein from Bacillus
subtilis (129 aa), FASTA scores: opt:273, E():
3.7e-09,(33.1% identity in 130 aa overlap); Q9KKT1|VCA1019
hypothetical protein from Vibrio cholerae (148 aa), FASTA
scores: opt: 258, E(): 3.1e-08, (34.9% identity in 126 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3005c"
/db_xref="EnsemblGenomes-Tr:CCP45811"
/db_xref="GOA:I6YAV3"
/db_xref="InterPro:IPR032808"
/db_xref="UniProtKB/TrEMBL:I6YAV3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45811.1"
/translation="MTSSNDSHWQRPDDSPGPMPGRPVSASLVDPEDDLTPARYAGDF
GSGTTTVIPPYDAASSGVGNSGYSLIEAAEPLPYVQPQPGRQVPAGSAGIDMDDDERV
RAAGRRGTQNLGLLILRVGLGAVLIAHGLQKLFGWWDGQGLAGFQNSLSDIGYQHAEI
LAYVSAGGEIVAGVLLVLGLFTPLAAAGALAFLINGLLAGISAQHSRPVAYFLQDGHE
YQITLVVMAVAVILSGPGRYGLDAARGWAHRPFIGSFVALLGGIAAGIAVWVLLNGAN
PLA"
gene 3364709..3365830
/gene="lppZ"
/locus_tag="Rv3006"
CDS 3364709..3365830
/codon_start=1
/transl_table=11
/gene="lppZ"
/locus_tag="Rv3006"
/product="Probable conserved lipoprotein LppZ"
/note="Rv3006, (MTV012.20), len: 373 aa. Probable
lppZ,conserved lipoprotein, equivalent to
O33109|MLCB637.17C|ML1699 putative lipoprotein from M.
leprae (372 aa), FASTA scores: opt: 2211, E():
4.3e-100,(87.1% identity in 373 aa overlap). Shows also
similarity (in part) with Q9Z571|SC8D9.20c putative
oxidoreductase from Streptomyces coelicolor (447 aa),
FASTA scores: opt: 185, E(): 0.051, (31.6% identity in 300
aa overlap); Q9Z9R3|BH2090 glucose dehydrogenase-B from
Bacillus halodurans (371 aa), FASTA scores: opt: 206, E():
0.0043,(28.3% identity in 205 aa overlap); and other
glucose dehydrogenases B. Contains signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site, followed by a
proline-rich domain."
/db_xref="EnsemblGenomes-Gn:Rv3006"
/db_xref="EnsemblGenomes-Tr:CCP45812"
/db_xref="GOA:I6Y293"
/db_xref="InterPro:IPR011041"
/db_xref="InterPro:IPR011042"
/db_xref="InterPro:IPR012938"
/db_xref="UniProtKB/TrEMBL:I6Y293"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45812.1"
/translation="MWTTRLVRSGLAALCAAVLVSSGCARFNDAQSQPFTTEPELRPQ
PSSTPPPPPPLPPVPFPKECPAPGVMQGCLESTSGLIMGIDSKTALVAERITGAVEEI
SISAEPKVKTVIPVDPAGDGGLMDIVLSPTYSQDRLMYAYISTPTDNRVVRVADGDIP
KDILTGIPKGAAGNTGALIFTSPTTLVVMTGDAGDPALAADPQSLAGKVLRIEQPTTI
GQTPPTTALSGIGSGGGLCIDPVDGSLYVADRTPTADRLQRITKNSEVSTVWTWPDKP
GVAGCAAMDGTVLVNLINTKLTVAVRLAPSTGAVTGEPDVVRKDTHAHAWALRMSPDG
NVWGATVNKTAGDAEKLDDVVFPLFPQGGGFPRNNDDKT"
gene complement(3365836..3366450)
/locus_tag="Rv3007c"
CDS complement(3365836..3366450)
/codon_start=1
/transl_table=11
/locus_tag="Rv3007c"
/product="Possible oxidoreductase"
/note="Rv3007c, (MTV012.21c), len: 204 aa. Possible
oxidoreductase, similar to Q9EWU5|3SC5B7.04c putative
oxidoreductase from Streptomyces coelicolor (162 aa),
FASTA scores: opt: 376, E(): 1.5e-18, (41.35% identity in
150 aa overlap); Q9K416|SCG22.29c putative
flavin-dependent reductase protein from Streptomyces
coelicolor (169 aa),FASTA scores: opt: 246, E(): 1e-09,
(34.1% identity in 135 aa overlap); and some similarity to
coupling proteins of 4-hydroxyphenylacetic
hydroxylase/monooxygenase e.g. Q9HWT6|HPAC|PA4092
Pseudomonas aeruginosa (170 aa), FASTA score: opt: 214;
O68232|HPAC Photorhabdus luminescens (Xenorhabdus
luminescens) (172 aa), FASTA score: opt: 198; Q9RPU2|HPAC
Salmonella dublin (170 aa), FASTA score: opt: 197; etc.
Equivalent to AAK47416 from Mycobacterium tuberculosis
strain CDC1551 (236 aa) but shorter 32 aa. Start chosen by
similarity."
/db_xref="EnsemblGenomes-Gn:Rv3007c"
/db_xref="EnsemblGenomes-Tr:CCP45813"
/db_xref="GOA:O53254"
/db_xref="InterPro:IPR002563"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/TrEMBL:O53254"
/protein_id="CCP45813.1"
/translation="MSEDVARIHDGDVIDESFDELMGMLDHPVFVVTTQADGHPAGCL
VSFATQTSVQPPSFMVGLPRSTGTSEVASRSEHLAVHVLSQRQHVLAELFGSQTEEEV
NKFARCSWRAGPCGMPILDDAAAWFIGRTASRSDVGDYVAYLLEPVSVWAPECSEDLL
YLSDLDFDVDDIDPGKEASPRFYERERGDETRRYGVVRFTLDVP"
gene 3366644..3367267
/locus_tag="Rv3008"
CDS 3366644..3367267
/codon_start=1
/transl_table=11
/locus_tag="Rv3008"
/product="Hypothetical protein"
/note="Rv3008, (MTV012.22), len: 207 aa (start uncertain).
Hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3008"
/db_xref="EnsemblGenomes-Tr:CCP45814"
/db_xref="UniProtKB/TrEMBL:I6YEY1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45814.1"
/translation="MLTVVAVIGILECGLVLHMPDNDLWYCGPWTLWVMAGRGVASGA
GVWRGDRVATPLAVAITAAGLVSGARIGPGAAAKRDPQLAQWNEIRSHYQEIAEWIDH
DTATAHPAVAATQISAAGSFGRANMVDYLGLLDSRADETVRRDEFSRWLSAKPDYLVT
TEQSVDAATIALPEFRHAYDRAATIGTLNVYRRNSPDGDEPLPADGN"
gene complement(3367264..3368793)
/gene="gatB"
/locus_tag="Rv3009c"
CDS complement(3367264..3368793)
/codon_start=1
/transl_table=11
/gene="gatB"
/locus_tag="Rv3009c"
/product="Probable glutamyl-tRNA(GLN) amidotransferase
(subunit B) GatB (Glu-ADT subunit B)"
/note="Rv3009c, (MT3089, MTV012.23c), len: 509 aa.
Probable gatB, Glu- tRNA-Gln amidotransferase, subunit B
,equivalent to O33107|GATB_MYCLE|MLCB637_15
glutamyl-tRNA(GLN) amidotransferase from Mycobacterium
leprae (509 aa), FASTA scores: opt: 2973, E():
2.9e-173,(88.4% identity in 509 aa overlap). Also highly
similar to other Glu- tRNA-Gln amidotransferases e.g.
Q9Z578|GATB|SC8D9.13 from Streptomyces coelicolor (504
aa),FASTA scores: opt: 2264, E(): 3.6e-130, (66.0%
identity in 495 aa overlap); P74215|GATB_SYNY3|SLL1435
from Synechocystis sp. strain PCC 6803 (519 aa), FASTA
scores: opt: 1289, E(): 6.7e-71, (42.0% identity in 485 aa
overlap); Q9X100|GATB_THEMA|TM1273 glutamyl-tRNA(GLN)
amidotransferase from Thermotoga maritima (482 aa), FASTA
scores: opt: 1165, E(): 2.2e-63, (40.05% identity in 487
aa overlap); etc. For more information about function, see
citation below. Similar to many members of the pet112
family. Belongs to the GatB family."
/db_xref="EnsemblGenomes-Gn:Rv3009c"
/db_xref="EnsemblGenomes-Tr:CCP45815"
/db_xref="GOA:P9WN61"
/db_xref="InterPro:IPR003789"
/db_xref="InterPro:IPR004413"
/db_xref="InterPro:IPR006075"
/db_xref="InterPro:IPR014746"
/db_xref="InterPro:IPR017958"
/db_xref="InterPro:IPR017959"
/db_xref="InterPro:IPR018027"
/db_xref="InterPro:IPR023168"
/db_xref="InterPro:IPR042114"
/db_xref="UniProtKB/Swiss-Prot:P9WN61"
/inference="protein motif:PROSITE:PS00041"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45815.1"
/translation="MTVAAGAAKAAGAELLDYDEVVARFQPVLGLEVHVELSTATKMF
CGCTTTFGGEPNTQVCPVCLGLPGSLPVLNRAAVESAIRIGLALNCEIVPWCRFARKN
YFYPDMPKNYQISQYDEPIAINGYLDAPLEDGTTWRVEIERAHMEEDTGKLTHIGSET
GRIHGATGSLIDYNRAGVPLIEIVTKPIVGAGARAPQIARSYVTALRDLLRALDVSDV
RMDQGSMRCDANVSLKPAGTTEFGTRTETKNVNSLKSVEVAVRYEMQRQGAILASGGR
ITQETRHFHEAGYTSAGRTKETAEDYRYFPEPDLEPVAPSRELVERLRQTIPELPWLS
RRRIQQEWGVSDEVMRDLVNAGAVELVAATVEHGASSEAARAWWGNFLAQKANEAGIG
LDELAITPAQVAAVVALVDEGKLSNSLARQVVEGVLAGEGEPEQVMTARGLALVRDDS
LTQAAVDEALAANPDVADKIRGGKVAAAGAIVGAVMKATRGQADAARVRELVLEACGQ
G"
gene complement(3368823..3369854)
/gene="pfkA"
/locus_tag="Rv3010c"
CDS complement(3368823..3369854)
/codon_start=1
/transl_table=11
/gene="pfkA"
/locus_tag="Rv3010c"
/product="Probable 6-phosphofructokinase PfkA
(phosphohexokinase) (phosphofructokinase)"
/note="Rv3010c, (MTV012.24c), len: 343 aa. Probable
pfkA,phosphofructokinase, equivalent to
O33106|K6PF_MYCLE|MLCB637.14 6-phosphofructokinase from
Mycobacterium leprae (343 aa), FASTA scores: opt:
2099,E(): 4.1e-122, (90.4% identity in 343 aa overlap).
Also highly similar to others e.g. Q9FC99|K6P3_STRCO from
Streptomyces coelicolor (341 aa), FASTA scores: opt:
1329,E(): 1.1e-74, (58.9% identity in 338 aa overlap);
Q9L1L8|K6P2_STRCO|PFKA2|PFK2|SC6A11.02
6-phosphofructokinase 2 from Streptomyces coelicolor (341
aa), FASTA scores: opt: 1303, E(): 4.5e-73, (56.7%
identity in 342 aa overlap); Q9KH71|PFP PPI-dependent
phosphofructokinase from Dictyoglomus thermophilum (346
aa), FASTA scores: opt: 893, E(): 8.4e-48, (41.85%
identity in 344 aa overlap); etc. Contains PS00433
Phosphofructokinase signature. Belongs to the
phosphofructokinase family."
/db_xref="EnsemblGenomes-Gn:Rv3010c"
/db_xref="EnsemblGenomes-Tr:CCP45816"
/db_xref="GOA:P9WID7"
/db_xref="InterPro:IPR000023"
/db_xref="InterPro:IPR012003"
/db_xref="InterPro:IPR012829"
/db_xref="InterPro:IPR015912"
/db_xref="InterPro:IPR022953"
/db_xref="InterPro:IPR035966"
/db_xref="UniProtKB/Swiss-Prot:P9WID7"
/inference="protein motif:PROSITE:PS00433"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45816.1"
/translation="MRIGVLTGGGDCPGLNAVIRAVVRTCHARYGSSVVGFQNGFRGL
LENRRVQLHNDDRNDRLLAKGGTMLGTARVHPDKLRAGLPQIMQTLDDNGIDVLIPIG
GEGTLTAASWLSEENVPVVGVPKTIDNDIDCTDVTFGHDTALTVATEAIDRLHSTAES
HERVMLVEVMGRHAGWIALNAGLASGAHMTLIPEQPFDIEEVCRLVKGRFQRGDSHFI
CVVAEGAKPAPGTIMLREGGLDEFGHERFTGVAAQLAVEVEKRINKDVRVTVLGHIQR
GGTPTAYDRVLATRFGVNAADAAHAGEYGQMVTLRGQDIGRVPLADAVRKLKLVPQSR
YDDAAAFFG"
gene complement(3369950..3371434)
/gene="gatA"
/locus_tag="Rv3011c"
CDS complement(3369950..3371434)
/codon_start=1
/transl_table=11
/gene="gatA"
/locus_tag="Rv3011c"
/product="Probable glutamyl-tRNA(GLN) amidotransferase
(subunit A) GatA (Glu-ADT subunit A)"
/note="Rv3011c, (MT3091, MTV012.25c), len: 494 aa.
Probable gatA, Glu-tRNA-Gln amidotransferase, subunit A ,
equivalent to O33105|GATA|ML1702|MLCB637.13
glutamyl-tRNA(GLN) amidotransferase from Mycobacterium
leprae (497 aa), FASTA scores: opt: 2839, E(): 3.5e-161,
(88.8% identity in 492 aa overlap). Also highly similar to
other Glu-tRNA-Gln amidotransferases e.g.
Q9Z580|GATA_STRCO from Streptomyces coelicolor (497 aa),
FASTA scores: opt: 2231, E(): 4.5e-125, (70.3% identity in
486 aa overlap); P73558|GATA_SYNY3|SLR0877 from
Synechocystis sp. strain PCC 6803 (483 aa), FASTA scores:
opt: 1593, E(): 3.3e-87,(55.85% identity in 487 aa
overlap); O06491|GATA_BACSU glutamyl-tRNA(GLN)
amidotransferase from Bacillus subtilis (485 aa), FASTA
scores: opt: 1389, E(): 4.3e-75, (51.7% identity in 468 aa
overlap); etc. For more information about function, see
citation below. Contains PS00017 ATP/GTP-binding site
motif A (P-loop). Belongs to the amidase family.
Nucleotide position 3370177 in the genome sequence has
been corrected, T:G resulting in M420L."
/db_xref="EnsemblGenomes-Gn:Rv3011c"
/db_xref="EnsemblGenomes-Tr:CCP45817"
/db_xref="GOA:P9WQA1"
/db_xref="InterPro:IPR000120"
/db_xref="InterPro:IPR004412"
/db_xref="InterPro:IPR020556"
/db_xref="InterPro:IPR023631"
/db_xref="InterPro:IPR036928"
/db_xref="UniProtKB/Swiss-Prot:P9WQA1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45817.1"
/translation="MTDIIRSDAATLAAKIAIKEVSSAEITRACLDQIEATDETYHAF
LHVAADEALAAAAAIDKQVAAGEPLPSALAGVPLALKDVFTTSDMPTTCGSKILEGWR
SPYDATLTARLRAAGIPILGKTNMDEFAMGSSTENSAYGPTRNPWNLDRVPGGSGGGS
AAALAAFQAPLAIGSDTGGSIRQPAALTATVGVKPTYGTVSRYGLVACASSLDQGGPC
ARTVLDTALLHQVIAGHDPRDSTSVDAEVPDVVGAARAGAVGDLRGVRVGVVRQLHGG
EGYQPGVLASFEAAVEQLTALGAEVSEVDCPHFDHALAAYYLILPSEVSSNLARFDAM
RYGLRVGDDGTRSAEEVMAMTRAAGFGPEVKRRIMIGTYALSAGYYDAYYNQAQKVRT
LIARDLDAAYRSVDVLVSPTTPTTAFRLGEKVDDPLAMYLFDLCTLPLNLAGHCGMSV
PSGLSPDDGLPVGLQIMAPALADDRLYRVGAAYEAARGPLLSAI"
gene complement(3371431..3371730)
/gene="gatC"
/locus_tag="Rv3012c"
CDS complement(3371431..3371730)
/codon_start=1
/transl_table=11
/gene="gatC"
/locus_tag="Rv3012c"
/product="Probable glutamyl-tRNA(GLN) amidotransferase
(subunit C) GatC (Glu-ADT subunit C)"
/note="Rv3012c, (MT3092, MTV012.26c), len: 99 aa. Probable
gatC, Glu-tRNA-Gln amidotransferase, subunit C, equivalent
to O33104|GATC_MYCLE|MLCB637.12 glutamyl-tRNA(GLN)
amidotransferase from Mycobacterium leprae (99 aa), FASTA
scores: opt: 483, E(): 3.1e-25, (74.75% identity in 99 aa
overlap). Also highly similar to other Glu-tRNA-Gln
amidotransferases e.g. Q9Z581|GATC_STRCO|SC8D9.10 from
Streptomyces coelicolor (98 aa), FASTA scores: opt:
298,E(): 4e-13, (53.7% identity in 95 aa overlap);
O06492|GATC_BACSU from B. subtilis (96 aa), FASTA scores:
opt: 222, E(): 3.7e-08, (43.15% identity in 95 aa
overlap); Q9KF29|BH0665 from Bacillus halodurans (96 aa),
FASTA scores: opt: 211, E(): 1.9e-07, (41.05% identity in
95 aa overlap); etc. For more information about function,
see citation below. Belongs to the GatC family."
/db_xref="EnsemblGenomes-Gn:Rv3012c"
/db_xref="EnsemblGenomes-Tr:CCP45818"
/db_xref="GOA:P9WN59"
/db_xref="InterPro:IPR003837"
/db_xref="InterPro:IPR036113"
/db_xref="UniProtKB/Swiss-Prot:P9WN59"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45818.1"
/translation="MSQISRDEVAHLARLARLALTETELDSFAGQLDAILTHVSQIQA
VDVTGVQATDNPLKDVNVTRPDETVPCLTQRQVLDQAPDAVDGRFAVPQILGDEQ"
gene 3371815..3372471
/locus_tag="Rv3013"
CDS 3371815..3372471
/codon_start=1
/transl_table=11
/locus_tag="Rv3013"
/product="Conserved protein"
/note="Rv3013, (MTV012.27), len: 218 aa. Conserved
protein,equivalent to O33103|MLCB637_11c hypothetical 24.4
KDA protein from Mycobacterium leprae (230 aa), FASTA
scores: opt: 1188, E(): 2.6e-67, (83.95% identity in 218
aa overlap). Equivalent to AAK47422 from Mycobacterium
tuberculosis strain CDC1551 (240 aa) but shorter 22 aa. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3013"
/db_xref="EnsemblGenomes-Tr:CCP45819"
/db_xref="InterPro:IPR002912"
/db_xref="UniProtKB/TrEMBL:O53260"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45819.1"
/translation="MRSYLLRIELADRPGSLGSLAVALGSVGADILSLDVVERGNGYA
IDDLVVELPPGAMPDTLITAAEALNGVRVDSVRPHTGLLEAHRELELLDHVAAAEGAT
ARLQVLVNEAPRVLRVSWCTVLRSSGGELHRLAGSPGAPETRANSAPWLPIERAAALD
GGADWVPQAWRDMDTTMVAAPLGDTHTAVVLGRPGPEFRPSEVARLGYLAGIVATMLR
"
gene complement(3372545..3374620)
/gene="ligA"
/gene_synonym="lig"
/locus_tag="Rv3014c"
CDS complement(3372545..3374620)
/codon_start=1
/transl_table=11
/gene="ligA"
/gene_synonym="lig"
/locus_tag="Rv3014c"
/product="DNA ligase [NAD dependent] LigA
(polydeoxyribonucleotide synthase [NAD+])"
/note="Rv3014c, (MT3094, MTV012.28c), len: 691 aa. ligA
(alternate gene name: lig), DNA ligase NAD-dependent (see
citation below), equivalent to
O33102|DNLJ_MYCLE|LIGA|LIG|ML1705|MLCB637.10 DNA ligase
from Mycobacterium leprae (694 aa), FASTA scores: opt:
3844, E(): 0, (84.7% identity in 687 aa overlap). Also
highly similar to many prokaryotic and eukaryotic ligases
e.g. Q9Z585|LIGA|SC8D9.06 from Streptomyces coelicolor
(735 aa), FASTA scores: opt: 2002, E(): 4e-113, (59.4%
identity in 714 aa overlap); P49421|DNLJ_RHOMR|LIGA|LIG
from Rhodothermus marinus (712 aa), FASTA scores: opt:
1835,E(): 4.6e-103, (45.55% identity in 685 aa overlap);
P15042|DNLJ_ECOLI|LIGA|LIG|DNAL|PDEC|lop|B2411 from
Escherichia coli strain K12 (671 aa), FASTA scores: opt:
1696, E(): 1.1e-94, (43.8% identity in 680 aa overlap);
etc. Belongs to the NAD-dependent DNA ligase family."
/db_xref="EnsemblGenomes-Gn:Rv3014c"
/db_xref="EnsemblGenomes-Tr:CCP45820"
/db_xref="GOA:P9WNV1"
/db_xref="InterPro:IPR001357"
/db_xref="InterPro:IPR001679"
/db_xref="InterPro:IPR004149"
/db_xref="InterPro:IPR004150"
/db_xref="InterPro:IPR010994"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR013839"
/db_xref="InterPro:IPR013840"
/db_xref="InterPro:IPR018239"
/db_xref="InterPro:IPR033136"
/db_xref="InterPro:IPR036420"
/db_xref="InterPro:IPR041663"
/db_xref="PDB:1ZAU"
/db_xref="PDB:3SGI"
/db_xref="UniProtKB/Swiss-Prot:P9WNV1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45820.1"
/translation="MSSPDADQTAPEVLRQWQALAEEVREHQFRYYVRDAPIISDAEF
DELLRRLEALEEQHPELRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELA
AWAGRIHAEVGDAAHYLCELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNARTI
ADVPERLTPGDDYPVPEVLEVRGEVFFRLDDFQALNASLVEEGKAPFANPRNSAAGSL
RQKDPAVTARRRLRMICHGLGHVEGFRPATLHQAYLALRAWGLPVSEHTTLATDLAGV
RERIDYWGEHRHEVDHEIDGVVVKVDEVALQRRLGSTSRAPRWAIAYKYPPEEAQTKL
LDIRVNVGRTGRITPFAFMTPVKVAGSTVGQATLHNASEIKRKGVLIGDTVVIRKAGD
VIPEVLGPVVELRDGSEREFIMPTTCPECGSPLAPEKEGDADIRCPNARGCPGQLRER
VFHVASRNGLDIEVLGYEAGVALLQAKVIADEGELFALTERDLLRTDLFRTKAGELSA
NGKRLLVNLDKAKAAPLWRVLVALSIRHVGPTAARALATEFGSLDAIAAASTDQLAAV
EGVGPTIAAAVTEWFAVDWHREIVDKWRAAGVRMVDERDESVPRTLAGLTIVVTGSLT
GFSRDDAKEAIVARGGKAAGSVSKKTNYVVAGDSPGSKYDKAVELGVPILDEDGFRRL
LADGPASRT"
gene complement(3374651..3375664)
/locus_tag="Rv3015c"
CDS complement(3374651..3375664)
/codon_start=1
/transl_table=11
/locus_tag="Rv3015c"
/product="Conserved hypothetical protein"
/note="Rv3015c, (MTV012.29c), len: 337 aa. Conserved
hypothetical protein, equivalent to Q9CBR6|ML1706
hypothetical protein from Mycobacterium leprae (337
aa),FASTA scores: opt: 1703, E(): 3.1e-92, (78.05%
identity in 337 aa overlap); and (but longer 47 aa)
O33101|MLCB637.09 hypothetical 30.0 KDA protein from
Mycobacterium leprae (290 aa), FASTA scores: opt: 1564,
E(): 2.4e-78, (78.6% identity in 290 aa overlap). Also
similar to Q9Z586|SC8D9.05 hypothetical 35.0 KDA protein
from Streptomyces coelicolor (331 aa), FASTA scores: opt:
774,E(): 4.7e-38, (43.4% identity in 334 aa overlap); and
showing similarity with other proteins e.g.
Q39586|METE_CHLRE 5-methyltetrahydropteroyltriglutamate--
homocysteine methyltransferase from Chlamydomonas
reinhardtii (814 aa),FASTA scores: opt: 162, E(): 0.048,
(27.05% identity in 355 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3015c"
/db_xref="EnsemblGenomes-Tr:CCP45821"
/db_xref="GOA:I6YAW3"
/db_xref="InterPro:IPR002629"
/db_xref="InterPro:IPR038071"
/db_xref="UniProtKB/TrEMBL:I6YAW3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45821.1"
/translation="MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGV
GADMLGRAGGLLVDVAIDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLR
GCGRAVKVQAPGPVTLVAGLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLD
TPVVVQFDEPSLPAALGGRLTGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCS
PDLPWDLLQRSRISAVSVDASTLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSME
EVAAAAVAVTDRLGVPRSALRDRLGVSPACGLANATGQWARTAVGLARDVAEAFARDP
EAI"
gene 3375758..3376387
/gene="lpqA"
/locus_tag="Rv3016"
CDS 3375758..3376387
/codon_start=1
/transl_table=11
/gene="lpqA"
/locus_tag="Rv3016"
/product="Probable lipoprotein LpqA"
/note="Rv3016, (MTV012.30), len: 209 aa. Probable
lpqA,lipoprotein. Contains signal sequence and
appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3016"
/db_xref="EnsemblGenomes-Tr:CCP45822"
/db_xref="InterPro:IPR026954"
/db_xref="InterPro:IPR038232"
/db_xref="UniProtKB/TrEMBL:I6Y2A3"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45822.1"
/translation="MVGLTRPLLLCGATLLIAACTRVVGGTASATFGGDRQGMLDVAT
ILLDQSRMQAITGSGDDLTIIPTMDTTYPVDVDDFAQPIPRECRFIYAETAVFGSEIE
AFHKTTFQDRPDGSLISEAAAAYRDAGTARRAFDTLAVTVHDCAASPAGWLFVSRWTA
GGNSLHIRAGDCGRDYRVLSAALLEVTFCGFPESVSDIVMTNIAANVPG"
gene complement(3376490..3376852)
/gene="esxQ"
/gene_synonym="ES6_8"
/gene_synonym="TB12.9"
/locus_tag="Rv3017c"
CDS complement(3376490..3376852)
/codon_start=1
/transl_table=11
/gene="esxQ"
/gene_synonym="ES6_8"
/gene_synonym="TB12.9"
/locus_tag="Rv3017c"
/product="ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like
protein 8)"
/note="Rv3017c, (MT3097, MTV012.31c), len: 120 aa.
EsxQ,ESAT-6 like protein (see citation below), possibly
secreted protein, very similar to AAK47433|MT3104 putative
secreted ESAT-6 like protein 9 from Mycobacterium
tuberculosis strain CDC1551 (96 aa), FASTA scores: opt:
315, E(): 1.2e-14, (65.7% identity in 70 aa overlap);
Rv3019c|O53266|MTV012.33c putative secreted ESAT-6 like
protein 9 from Mycobacterium tuberculosis (96 aa), FASTA
scores: opt: 315, E(): 1.2e-14, (65.7% identity in 70 aa
overlap) and Rv0288|O53693|CFP7|MT0301|MTV035.16 10 KDA
antigen CFP7 (low molecular weight protein antigen 7)
(CFP-7) from Mycobacterium tuberculosis (95 aa), FASTA
scores: opt: 303, E(): 7.4e-14, (66.2% identity in 68 aa
overlap). An alternative start site exists at 3376801.
Belongs to the ESAT6 family. Note previously known as
TB12.9."
/db_xref="EnsemblGenomes-Gn:Rv3017c"
/db_xref="EnsemblGenomes-Tr:CCP45823"
/db_xref="GOA:P9WNJ1"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45823.1"
/translation="MSQSMYSYPAMTANVGDMAGYTGTTQSLGADIASERTAPSRACQ
GDLGMSHQDWQAQWNQAMEALARAYRRCRRALRQIGVLERPVGDSSDCGTIRVGSFRG
RWLDPRHAGPATAADAGD"
gene complement(3376939..3378243)
/gene="PPE46"
/locus_tag="Rv3018c"
CDS complement(3376939..3378243)
/codon_start=1
/transl_table=11
/gene="PPE46"
/locus_tag="Rv3018c"
/product="PPE family protein PPE46"
/note="Rv3018c, (MTV012.32c), len: 434 aa. PPE46, Member
of PPE family but lacks Gly, Ala rich repeats at
C-terminal domain, closest to MTCY261.19. See citation
below. Also very similar to following ORF MTV012.35c.
Nearly identical in parts to Mycobacterium tuberculosis
protein erroneously described as dihydrofolate reductase
(X59271|MTFOLA_1) P31500|DYR_MYCTU (214 aa), FASTA scores:
opt: 972, E(): 4.4e-42, (80.0% identity in 195 aa
overlap); and Z97559|MTCY261_19 from Mycobacterium
tuberculosis cosmid (473 aa), FASTA scores: opt: 806, E():
0; (38.8% identity in 479 aa overlap); and
O53268|MTV012.35c from Mycobacterium tuberculosis (358
aa), FASTA scores: opt: 1714, E(): 3.3e-79, (78.3%
identity in 355 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3018c"
/db_xref="EnsemblGenomes-Tr:CCP45824"
/db_xref="GOA:P9WHY9"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHY9"
/protein_id="CCP45824.1"
/translation="MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAV
AQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAAGEHEAAAAGYVC
ALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAV
VGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLS
ALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIA
GVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGA
PAALVGSVAPVSGGVVSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESV
GQPAGLTVLADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV"
gene complement(3378329..3378415)
/gene="PE27A"
/locus_tag="Rv3018A"
CDS complement(3378329..3378415)
/codon_start=1
/transl_table=11
/gene="PE27A"
/locus_tag="Rv3018A"
/product="PE family protein PE27A"
/note="Rv3018A, len: 28 aa. PE27A, Member of Mycobacterium
tuberculosis PE family (see Brennan and Delogu, 2002),
most similar to Rv0285 (102 aa), FASTA scores: opt: 147,
E(): 3.5e-05, (92.85% identity in 28 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3018A"
/db_xref="EnsemblGenomes-Tr:CCP45825"
/db_xref="UniProtKB/TrEMBL:Q6MX19"
/protein_id="CCP45825.1"
/translation="MTLSVVPEGLAAASAAVEALTARLAAAH"
gene complement(3378711..3379001)
/gene="esxR"
/gene_synonym="ES6_9"
/gene_synonym="TB10.3"
/locus_tag="Rv3019c"
CDS complement(3378711..3379001)
/codon_start=1
/transl_table=11
/gene="esxR"
/gene_synonym="ES6_9"
/gene_synonym="TB10.3"
/locus_tag="Rv3019c"
/product="Secreted ESAT-6 like protein EsxR (TB10.3)
(ESAT-6 like protein 9)"
/note="Rv3019c, (MT3104, MTV012.33c), len: 96 aa.
EsxR,secreted ESAT-6 like protein (see citations below),
most similar to O53693|AAK44525|Rv0288|CFP7|MT0301|MTV035.
16 10 KDA antigen CFP7 (low molecular weight protein
antigen 7) (CFP-7) from Mycobacterium tuberculosis (95
aa), FASTA scores: opt: 566, E(): 5.1e-31, (84.3% identity
in 95 aa overlap). Also similar to Q9CD33|ML2531 possible
cell surface protein from Mycobacterium leprae (96 aa),
FASTA scores: opt: 472, E(): 8.3e-25, (66.6% identity in
96 aa overlap); O53264|Rv3017c|MTV012.31c putative
secreted antigen from Mycobacterium tuberculosis (120 aa),
FASTA scores: opt: 321, E(): 9.6e-15, (67.15% identity in
70 aa overlap); Q57165|AAK48357|O84901|X79562|ESAT6|Rv3875
|MT3989|MTV027.1 0esat6 gene from Mycobacterium
tuberculosis strain Erdman (94 aa), FASTA scores: opt:
131, E(): 0.028, (26.1% identity in 88 aa overlap).
Belongs to the ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv3019c"
/db_xref="EnsemblGenomes-Tr:CCP45826"
/db_xref="GOA:P9WNI9"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:3H6P"
/db_xref="UniProtKB/Swiss-Prot:P9WNI9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45826.1"
/translation="MSQIMYNYPAMMAHAGDMAGYAGTLQSLGADIASEQAVLSSAWQ
GDTGITYQGWQTQWNQALEDLVRAYQSMSGTHESNTMAMLARDGAEAAKWGG"
gene complement(3379036..3379329)
/gene="esxS"
/gene_synonym="PE28"
/locus_tag="Rv3020c"
CDS complement(3379036..3379329)
/codon_start=1
/transl_table=11
/gene="esxS"
/gene_synonym="PE28"
/locus_tag="Rv3020c"
/product="ESAT-6 like protein EsxS"
/note="Rv3020c, (MTV012.34c), len: 97 aa. EsxS, ESAT-6
like protein. PE-family related protein; distant member of
the Mycobacterium tuberculosis PE family, similar to
AAK44524|MT0300 PE family protein from M. tuberculosis
strain CDC1551 (97 aa), FASTA scores: opt: 564, E():
5.9e-30, (91.75% identity in 97 aa overlap). Has potential
helix-turn-helix motif at positions 14-35. Seems to belong
to the ESAT6 family (see Betts et al., 2002). Note that
previously known as PE28. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv3020c"
/db_xref="EnsemblGenomes-Tr:CCP45827"
/db_xref="GOA:Q6MX18"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:3H6P"
/db_xref="UniProtKB/Swiss-Prot:Q6MX18"
/protein_id="CCP45827.1"
/translation="MSLLDAHIPQLIASHTAFAAKAGLMRHTIGQAEQQAMSAQAFHQ
GESAAAFQGAHARFVAAAAKVNTLLDIAQANLGEAAGTYVAADAAAASSYTGF"
gene complement(3379376..3380452)
/pseudo
/gene="PPE47"
/locus_tag="Rv3021c"
CDS complement(3379376..3380452)
/codon_start=1
/transl_table=11
/gene="PPE47"
/locus_tag="Rv3021c"
/product="PPE family protein PPE47"
/note="Rv3021c, (MTV012.35c), len: 358 aa. PPE47, Member
of Mycobacterium tuberculosis PPE family. Should be
continuation of upstream ORF MTV012.36c but is
frameshifted due to missing base at 36448 in v012.
Sequence has been checked but no error apparent. Very
similar to neighbouring ORF O53265|MTV012.32c|Rv3018c from
Mycobacterium tuberculosis (434 aa), FASTA scores: opt:
1714, E(): 6.6e-770, (78.3% identity in 355 aa overlap)
and AAK47430|MT3101 (strongly in the N-terminal part) (310
aa),FASTA scores: opt: 897, E(): 4.5e-37, (66.95% identity
in 227 aa overlap)."
/db_xref="PSEUDO:CCP45828.1"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHY7"
/pseudogene="unknown"
gene complement(3380440..3380682)
/pseudo
/gene="PPE48"
/locus_tag="Rv3022c"
CDS complement(3380440..3380682)
/codon_start=1
/transl_table=11
/gene="PPE48"
/locus_tag="Rv3022c"
/product="PPE family protein PPE48"
/note="Rv3022c, (MTV012.36c), len: 81 aa. PPE48, Member of
M. tuberculosis PPE family with frameshift due to missing
bp in codon 82. The ORF continues in downstream
MTV012.35c. The sequence has been checked and no errors
were detected. Identical to neigbouring ORF
O53265|Rv3018c|MTV012.32c (434 aa), FASTA scores: opt:
526, E(): 6.2e-26, (100.0% identity in 81 aa overlap); and
O69706|Rv739c|MTV025.087c (77 aa),FASTA scores: opt: 392,
E(): 3.4e-18, (72.7% identity in 77 aa overlap)."
/pseudogene="unknown"
gene complement(3380679..3380993)
/gene="PE29"
/locus_tag="Rv3022A"
CDS complement(3380679..3380993)
/codon_start=1
/transl_table=11
/gene="PE29"
/locus_tag="Rv3022A"
/product="PE family protein PE29"
/note="Rv3022A, len: 104 aa. PE29, Member of the
Mycobacterium tuberculosis PE family (see Brennan and
Delogu, 2002), similar to many others e.g.
Rv0285|AL021930_12 from Mycobacterium tuberculosis (102
aa), FASTA scores: opt: 497, E(): 3e-21, (80.39% identity
in 102 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3022A"
/db_xref="EnsemblGenomes-Tr:CCP45830"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MX17"
/protein_id="CCP45830.1"
/translation="MTLRVVPEGLAAASAAVEALTARLAAAHAGAAPAITAVVAPAAD
PVSLQSAVGFSALGSEHAAIAGEGVEELGRSGVAVGESGIGYAAGDAVAAATYLVSGG
SL"
mobile_element 3381351..3382674
/mobile_element_type="insertion sequence:IS1081-5"
/note="IS1081-5, len: 1324 nt. Insertion sequence IS1081."
repeat_region 3381351..3381365
/note="15 bp Inverted repeat at left end of
IS1081:TCGCGTGATCCTTCG"
gene complement(3381375..3382622)
/locus_tag="Rv3023c"
CDS complement(3381375..3382622)
/codon_start=1
/transl_table=11
/locus_tag="Rv3023c"
/product="Probable transposase"
/note="Rv3023c, (MTV012.38c), len: 415 aa. Probable IS1081
transposase. Contains PS01007 Transposases, Mutator
family,signature. Similars to
P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c and
Rv2512c|MTCY07A7.18c transposases for insertion sequence
element IS1081 (415 aa), FASTA scores: opt: 2675, E():
1.8e-162, (100.0% identity in 415 aa overlap). Belongs to
the mutator family of transposase."
/db_xref="EnsemblGenomes-Gn:Rv3023c"
/db_xref="EnsemblGenomes-Tr:CCP45831"
/db_xref="GOA:P96354"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/TrEMBL:P96354"
/inference="protein motif:PROSITE:PS01007"
/protein_id="CCP45831.1"
/translation="MTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADAL
CGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERA
LTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGP
YTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRD
LVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRT
LLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIW
SNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRA
RAALTSTEEPAKQQTTNTPALTT"
repeat_region complement(3382660..3382674)
/note="15 bp Inverted repeat at the right end of
IS1081:TCGCGTGATCCTTCG"
gene complement(3382785..3383888)
/gene="trmU"
/locus_tag="Rv3024c"
CDS complement(3382785..3383888)
/codon_start=1
/transl_table=11
/gene="trmU"
/locus_tag="Rv3024c"
/product="Probable tRNA
(5-methylaminomethyl-2-thiouridylate)-methyltransferase
TrmU"
/note="Rv3024c, (MT3108, MTV012.39c), len: 367 aa.
Probable trmU, tRNA
(5-methylaminomethyl-2-thiouridylate)-methyltransferase
,equivalent to O33099|TRMU_MYCLE|ML1707|MLCB637.07
probable tRNA (5-methylaminomethyl-2-thiouridylate)-
methyltransferase from Mycobacterium leprae (358 aa),
FASTA scores: opt: 2033, E(): 5.5e-116, (85.45% identity
in 357 aa overlap). Also highly similar to others e.g.
O86583|TRMU_STRCO|SC2A11.22 from Streptomyces coelicolor
(376 aa), FASTA scores: opt: 1336, E(): 1e-73, (56.9%
identity in 369 aa overlap); BAB49856|MLR2824 from
Rhizobium loti (378 aa), FASTA scores: opt: 826, E():
8.3e-43, (42.35% identity in 359 aa overlap);
Q9ZDM1|TRMU_RICPR|RP306 from Rickettsia prowazekii (358
aa), FASTA scores: opt: 800, E(): 3e-41, (40.1% identity
in 359 aa overlap); etc. Belongs to the TrmU family."
/db_xref="EnsemblGenomes-Gn:Rv3024c"
/db_xref="EnsemblGenomes-Tr:CCP45832"
/db_xref="GOA:P9WJS5"
/db_xref="InterPro:IPR004506"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR023382"
/db_xref="UniProtKB/Swiss-Prot:P9WJS5"
/protein_id="CCP45832.1"
/translation="MKVLAAMSGGVDSSVAAARMVDAGHEVVGVHMALSTAPGTLRTG
SRGCCSKEDAADARRVADVLGIPFYVWDFAEKFKEDVINDFVSSYARGETPNPCVRCN
QQIKFAALSARAVALGFDTVATGHYARLSGGRLRRAVDRDKDQSYVLAVLTAQQLRHA
AFPIGDTPKRQIRAEAARRGLAVANKPDSHDICFIPSGNTKAFLGERIGVRRGVVVDA
DGVVLASHDGVHGFTIGQRRGLGIAGPGPNGRPRYVTAIDADTATVHVGDVTDLDVQT
LTGRAPVFTAGAAPSGPVDCVVQVRAHGETVSAVAELIGDALFVQLHAPLRGVARGQT
LVLYRPDPAGDEVLGSATIAGASGLSTGGNPGA"
gene complement(3383885..3385066)
/gene="iscS"
/gene_synonym="nifS"
/locus_tag="Rv3025c"
CDS complement(3383885..3385066)
/codon_start=1
/transl_table=11
/gene="iscS"
/gene_synonym="nifS"
/locus_tag="Rv3025c"
/product="Cysteine desulfurase IscS (NIFS protein homolog)
(nitrogenase metalloclusters biosynthesis protein NIFS)"
/note="Rv3025c, (MTV012.40c), len: 393 aa. IscS (alternate
gene name: nifS), cysteine desulfurase (NifS-like protein)
, equivalent to MLCB637.06|O33098 NIFS-like protein from
Mycobacterium leprae (396 aa), FASTA scores: opt:
2186,E(): 2.7e-122, (84.9% identity in 391 aa overlap).
Also highly similar to many e.g. O86581|SC2A11.20 putative
pyridoxal-phosphate-dependent aminotransferase from
Streptomyces coelicolor (389 aa), FASTA scores: opt:
1568,E(): 1.1e-85, (61.7% identity in 389 aa overlap);
P57795|ISCS|NIFS cysteine desulfurase (NIFS protein
homolog) from Methanosarcina thermophila (404 aa), FASTA
scores: opt: 1059, E(): 1.6e-55, (46.2% identity in 381 aa
overlap); O54055|ISCS_RUMFL|ISCS|NIFS cysteine desulfurase
from Ruminococcus flavefaciens (396 aa), FASTA scores:
opt: 973, E(): 2e-50, (43.3% identity in 381 aa overlap);
P57794|NIFS_ACEDI cysteine desulfurase from Acetobacter
diazotrophicus (400 aa), FASTA scores: opt: 958, E():
1.6e-49, (41.1% identity in 392 aa overlap); etc. Also
similar to Rv1464|MTV007.11 from Mycobacterium
tuberculosis. Contains PS00595 Aminotransferases class-V
pyridoxal-phosphate attachment site. Belongs to class-V of
pyridoxal-phosphate-dependent aminotransferases, NIFS/ISCS
subfamily. Cofactor: pyridoxal phosphate (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3025c"
/db_xref="EnsemblGenomes-Tr:CCP45833"
/db_xref="GOA:P9WQ71"
/db_xref="InterPro:IPR000192"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR016454"
/db_xref="PDB:4ISY"
/db_xref="UniProtKB/Swiss-Prot:P9WQ71"
/inference="protein motif:PROSITE:PS00595"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45833.1"
/translation="MAYLDHAATTPMHPAAIEAMAAVQRTIGNASSLHTSGRSARRRI
EEARELIADKLGARPSEVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHA
VLDSVNWLVEHEGAHVTWLPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTIL
PIAEMSVVAMEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLR
RDVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVE
GVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDANGIECSTGSACTAGVA
QPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVLPGAVARARRAALAAAGAS
R"
gene complement(3385163..3386077)
/locus_tag="Rv3026c"
CDS complement(3385163..3386077)
/codon_start=1
/transl_table=11
/locus_tag="Rv3026c"
/product="Conserved hypothetical protein"
/note="Rv3026c, (MTV012.41c), len: 304 aa. Conserved
hypothetical protein, similar to Q9RCZ0|SCM10.08C putative
acyltransferase from Streptomyces coelicolor (275
aa),FASTA scores: opt: 393, E(): 2.2e-17, (41.4% identity
in 299 aa overlap). Similar in part to other hypothetical
proteins and acyltransferases e.g. BAB51968|MLR5533 from
Rhizobium loti (266 aa), FASTA scores: opt: 280, E():
2.4e-10, (29.45% identity in 258 aa overlap); Q9KIH9
putative acyltransferase (putative acyltransferase
transmembrane protein) from Rhizobium meliloti
(Sinorhizobium meliloti) (292 aa), FASTA scores: opt:
252,E(): 1.4e-08, (30.5% identity in 210 aa overlap);
O69114|PLSC putative 1-acyl-SN-glycerol-3-phosphate
acyltransferase from Burkholderia pseudomallei
(Pseudomonas pseudomallei) (289 aa), FASTA scores: opt:
216, E(): 2.4e-06, (30.85% identity in 269 aa overlap);
etc. So may be a member of acyltransferase family
protein."
/db_xref="EnsemblGenomes-Gn:Rv3026c"
/db_xref="EnsemblGenomes-Tr:CCP45834"
/db_xref="GOA:I6XFY8"
/db_xref="InterPro:IPR002123"
/db_xref="UniProtKB/TrEMBL:I6XFY8"
/protein_id="CCP45834.1"
/translation="MSAPAVTEHSWLPRATCGVSCVSVGDAAQVRRPLVVLRVALRVM
LALLLVPGVPLVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSPVRNLRGVLVVSGHV
SWLDVFCIGSVLPGSFVARADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARR
LRAGQTVVAFPEGTTWCGRPGDDAGRPAARAGAGCSHRGCGAFYPAMFQAAIDAGRPV
QPLRLTYHHVDGTVSTAPAFVGDDTLVRSVCRLLTVRRTLAWVRVESLQLPGTDRRNL
ARRCQSAVLAGALGQSGQRPGRRHVPAT"
gene complement(3386074..3386919)
/locus_tag="Rv3027c"
CDS complement(3386074..3386919)
/codon_start=1
/transl_table=11
/locus_tag="Rv3027c"
/product="GCN5-related N-acetyltransferase"
/note="Rv3027c, (MTV012.42c), len: 281 aa. Probable
acetyltransferase. Contains GNAT (Gcn5-related
N-acetyltransferase) domain in N-terminal part. See
Vetting et al. 2005. Similar, to others e.g.
Q9RCY9|SCM10.09c from Streptomyces coelicolor (256 aa),
FASTA scores: opt: 498,E(): 7.8e-24, (47.7% identity in
237 aa overlap); BAB50158|MLR3216 from Rhizobium loti (291
aa), FASTA scores: opt: 359, E(): 3.7e-15, (33.35%
identity in 246 aa overlap); etc. Start changed since
first submission,extended by 25 aa."
/db_xref="EnsemblGenomes-Gn:Rv3027c"
/db_xref="EnsemblGenomes-Tr:CCP45835"
/db_xref="GOA:I6YEZ8"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:I6YEZ8"
/protein_id="CCP45835.1"
/translation="MSIASVLIPSDKPHGVATGSSTGPRYSLLLSTDPSMVEAAQRLR
YDVFSTTPGFALPAAADTRRDGDRFDEYCDHLLVRDDDTGELVGCYRMLAPAGAIAAG
GLYTATEFDVCAFDPLRPSLVEMGRAVVREGHRNGGVVLLMWAGILAYLDRYGYDYVT
GCVSVPIGGDGETPGSRLRGVRDFILNRHAAPPQCQVYPYRPVRVDGRSLDDILPPPR
PAVPPLMRGYLRLGARACGEPAHDPDFGVGDFCLLLDKDHADTRYLRRLRSVAAASEM
VNDAR"
gene complement(3387075..3388031)
/gene="fixB"
/gene_synonym="etfA"
/locus_tag="Rv3028c"
CDS complement(3387075..3388031)
/codon_start=1
/transl_table=11
/gene="fixB"
/gene_synonym="etfA"
/locus_tag="Rv3028c"
/product="Probable electron transfer flavoprotein
(alpha-subunit) FixB (alpha-ETF) (electron transfer
flavoprotein large subunit) (ETFLS)"
/note="Rv3028c, (MTV012.43c), len: 318 aa. Probable fixB
(alternate gene name: etfA), electron transfer
flavoprotein (alpha subunit) for various dehydrogenases.
Equivalent to O33096|ETFA_MYCLE|FIXB|ML1711|MLCB637.04
electron transfer flavoprotein from Mycobacterium leprae
(318 aa), FASTA scores: opt: 1788, E(): 1.1e-87, (89.3%
identity in 318 aa overlap). Also highly similar to many
e.g. Q9K418|SCG22.27c from Streptomyces coelicolor (320
aa), FASTA scores: opt: 1161, E(): 1.6e-54, (59.45%
identity in 323 aa overlap); AAK08137|etfa from
Rhodobacter sphaeroides (308 aa), FASTA scores: opt: 792,
E(): 5.1e-35, (45.95% identity in 309 aa overlap);
P38974|ETFA_PARDE electron transfer flavoprotein from
Paracoccus denitrificans (307 aa), FASTA scores: opt: 789,
E(): 7.4e-35, (45.95% identity in 309 aa overlap); etc.
Belongs to the Etf alpha-subunit / FixB family."
/db_xref="EnsemblGenomes-Gn:Rv3028c"
/db_xref="EnsemblGenomes-Tr:CCP45836"
/db_xref="GOA:P9WNG9"
/db_xref="InterPro:IPR001308"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR014730"
/db_xref="InterPro:IPR014731"
/db_xref="InterPro:IPR018206"
/db_xref="InterPro:IPR029035"
/db_xref="InterPro:IPR033947"
/db_xref="UniProtKB/Swiss-Prot:P9WNG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45836.1"
/translation="MAEVLVLVEHAEGALKKVSAELITAARALGEPAAVVVGVPGTAA
PLVDGLKAAGAAKIYVAESDLVDKYLITPAVDVLAGLAESSAPAGVLIAATADGKEIA
GRLAARIGSGLLVDVVDVREGGVGVHSIFGGAFTVEAQANGDTPVITVRAGAVEAEPA
AGAGEQVSVEVPAAAENAARITAREPAVAGDRPELTEATIVVAGGRGVGSAENFSVVE
ALADSLGAAVGASRAAVDSGYYPGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTS
KTIVAVNKDEEAPIFEIADYGVVGDLFKVAPQLTEAIKARKG"
gene complement(3388070..3388870)
/gene="fixA"
/gene_synonym="etfB"
/locus_tag="Rv3029c"
CDS complement(3388070..3388870)
/codon_start=1
/transl_table=11
/gene="fixA"
/gene_synonym="etfB"
/locus_tag="Rv3029c"
/product="Probable electron transfer flavoprotein
(beta-subunit) FixA (beta-ETF) (electron transfer
flavoprotein small subunit) (ETFSS)"
/note="Rv3029c, (MTV012.44c), len: 266 aa. Probable fixA
(alternate gene name: etfB), electron transfer
flavoprotein (beta-subunit). Equivalent of
O33095|ETFB_MYCLE|FixA|MLCB637.03 electron transfer
flavoprotein from Mycobacterium leprae (266 aa), FASTA
scores: opt: 1603, E(): 7.6e-87, (95.1% identity in 266 aa
overlap). Also highly similar to others e.g.
Q9K417|SCG22.28c from Streptomyces coelicolor (262
aa),FASTA scores: opt: 860, E(): 2.3e-43, (52.4% identity
in 263 aa overlap); O85691|ETFB_MEGEL from Megasphaera
elsdenii (270 aa), FASTA scores: opt: 548, E():
4.2e-25,(35.15% identity in 273 aa overlap); etc. Also
highly similar in particular to Q9KHD0|NONH flavoprotein
reductase from Streptomyces griseus subsp. griseus (this
one is required for macrotetrolide biosynthesis in
Streptomyces griseus) (261 aa), FASTA scores: opt: 867,
E(): 8.8e-44,(54.0% identity in 263 aa overlap). Belongs
to the Etf beta-subunit / FixA family."
/db_xref="EnsemblGenomes-Gn:Rv3029c"
/db_xref="EnsemblGenomes-Tr:CCP45837"
/db_xref="GOA:P9WNG7"
/db_xref="InterPro:IPR000049"
/db_xref="InterPro:IPR012255"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR014730"
/db_xref="InterPro:IPR033948"
/db_xref="UniProtKB/Swiss-Prot:P9WNG7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45837.1"
/translation="MTNIVVLIKQVPDTWSERKLTDGDFTLDREAADAVLDEINERAV
EEALQIREKEAADGIEGSVTVLTAGPERATEAIRKALSMGADKAVHLKDDGMHGSDVI
QTGWALARALGTIEGTELVIAGNESTDGVGGAVPAIIAEYLGLPQLTHLRKVSIEGGK
ITGERETDEGVFTLEATLPAVISVNEKINEPRFPSFKGIMAAKKKEVTVLTLAEIGVE
SDEVGLANAGSTVLASTPKPAKTAGEKVTDEGEGGNQIVQYLVAQKII"
gene 3389101..3389925
/locus_tag="Rv3030"
CDS 3389101..3389925
/codon_start=1
/transl_table=11
/locus_tag="Rv3030"
/product="Conserved protein"
/note="Rv3030, (MTV012.45), len: 274 aa. Conserved
protein,equivalent to O33094|MLCB637.02c|ML1713
hypothetical 30.8 KDa protein from Mycobacterium leprae
(280 aa), FASTA scores: opt: 1388, E(): 5.5e-83, (78.2%
identity in 280 aa overlap). N-terminus has similarity to
hypothetical proteins from a number of organisms and to
Q54303|EMBL:X86780|RAPM methyltransferase from
Streptomyces hygroscopicus (317 aa), FASTA scores: opt:
191, E(): 3.6e-05, (35.65% identity in 101 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3030"
/db_xref="EnsemblGenomes-Tr:CCP45838"
/db_xref="GOA:P9WJZ1"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WJZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45838.1"
/translation="MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENY
WFRRHQVVYQRLAPRCTARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSR
YPRVEVMQANLAELPLPDASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTP
NRITFSPGRDTPINPFHTRELNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGG
SIIDAQIMRAVAGAPWPPELAADVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP"
gene 3389922..3391502
/locus_tag="Rv3031"
CDS 3389922..3391502
/codon_start=1
/transl_table=11
/locus_tag="Rv3031"
/product="Conserved protein"
/note="Rv3031, (MTV012.46), len: 526 aa. Conserved
protein,equivalent to Q9CBR4|ML1714 hypothetical protein
from Mycobacterium leprae (522 aa), FASTA scores: opt:
3167,E(): 4.4e-190, (86.15% identity in 526 aa overlap);
and highly similar to truncated O33093|MLCB637.01c
hypothetical 37.2 KDA protein (fragment) from
Mycobacterium leprae (338 aa), FASTA scores: opt: 2041,
E(): 5.7e-120, (84.8% identity in 342 aa overlap). Also
some similarity to hypothetical proteins Q9V0M7|PAB1857
from Pyrococcus abyssi (602 aa), FASTA scores: opt: 477,
E(): 3.5e-22, (31.2% identity in 556 aa overlap); and
Synechocystis P74630|D90916|SLL0735 from Synechocystis sp.
strain PCC 6803 (529 aa), FASTA scores: opt: 282, E():
4.7e-10, (28.6% identity in 560 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3031"
/db_xref="EnsemblGenomes-Tr:CCP45839"
/db_xref="GOA:P9WQ27"
/db_xref="InterPro:IPR004300"
/db_xref="InterPro:IPR011330"
/db_xref="InterPro:IPR015293"
/db_xref="InterPro:IPR027291"
/db_xref="InterPro:IPR028995"
/db_xref="InterPro:IPR037090"
/db_xref="InterPro:IPR040042"
/db_xref="UniProtKB/Swiss-Prot:P9WQ27"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45839.1"
/translation="MNTSASPVPGLFTLVLHTHLPWLAHHGRWPVGEEWLYQSWAAAY
LPLLQVLAALADENRHRLITLGMTPVVNAQLDDPYCLNGVHHWLANWQLRAEEAASVR
YARQSKSADYPSCTPEALRAFGIRECADAARALDNFATRWRHGGSPLLRGLIDAGTVE
LLGGPLAHPFQPLLAPRLREFALREGLADAQLRLAHRPKGIWAPECAYAPGMEVDYAT
AGVSHFMVDGPSLHGDTALGRPVGKTDVVAFGRDLQVSYRVWSPKSGYPGHAAYRDFH
TYDHLTGLKPARVTGRNVPSEQKAPYDPERADRAVDVHVADFVDVVRNRLLSESERIG
RPAHVIAAFDTELFGHWWYEGPTWLQRVLRALPAAGVRVGTLSDAIADGFVGDPVELP
PSSWGSGKDWQVWSGAKVADLVQLNSEVVDTALTTIDKALAQTASLDGPLPRDHVADQ
ILRETLLTVSSDWPFMVSKDSAADYARYRAHLHAHATREIAGALAAGRRDTARRLAEG
WNRADGLFGALDARRLPK"
gene 3391534..3392778
/locus_tag="Rv3032"
CDS 3391534..3392778
/codon_start=1
/transl_table=11
/locus_tag="Rv3032"
/product="Alpha (1->4) glucosyltransferase"
/note="Rv3032, (MTV012.47), len: 414 aa. Alpha (1->4)
glucosyltransferase (See Stadthagen et al., 2007).
Equivalent to Q9CBR3|ML1715 putative transferase from
Mycobacterium leprae (438 aa), FASTA scores: opt:
2456,E(): 7.3e-145, (87.9% identity in 414 aa overlap).
Also similar to hypothetical proteins and various
transferases e.g. P73369|SLL1971 hypothetical 46.2 KDA
protein from Synechocystis sp. strain PCC 6803 (404 aa),
FASTA scores: opt: 584, E(): 7.3e-29, (34.5% identity in
400 aa overlap); Q9Z5B7|SC2G5.06 putative transferase from
Streptomyces coelicolor (406 aa), FASTA scores: opt: 509,
E(): 3.3e-24,(35.9% identity in 413 aa overlap);
Q9UZA1|PAB0827 galactosyltransferase (LPS biosynthesis
RFBU related protein) from Pyrococcus abyssi (371 aa),
FASTA scores: opt: 381, E(): 2.6e-16, (26.75% identity in
404 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3032"
/db_xref="EnsemblGenomes-Tr:CCP45840"
/db_xref="GOA:P9WMY9"
/db_xref="InterPro:IPR001296"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/Swiss-Prot:P9WMY9"
/protein_id="CCP45840.1"
/translation="MRILMVSWEYPPVVIGGLGRHVHHLSTALAAAGHDVVVLSRCPS
GTDPSTHPSSDEVTEGVRVIAAAQDPHEFTFGNDMMAWTLAMGHAMIRAGLRLKKLGT
DRSWRPDVVHAHDWLVAHPAIALAQFYDVPMVSTIHATEAGRHSGWVSGALSRQVHAV
ESWLVRESDSLITCSASMNDEITELFGPGLAEITVIRNGIDAARWPFAARRPRTGPAE
LLYVGRLEYEKGVHDAIAALPRLRRTHPGTTLTIAGEGTQQDWLIDQARKHRVLRATR
FVGHLDHTELLALLHRADAAVLPSHYEPFGLVALEAAAAGTPLVTSNIGGLGEAVING
QTGVSCAPRDVAGLAAAVRSVLDDPAAAQRRARAARQRLTSDFDWQTVATATAQVYLA
AKRGERQPQPRLPIVEHALPDR"
gene 3392812..3393201
/locus_tag="Rv3032A"
CDS 3392812..3393201
/codon_start=1
/transl_table=11
/locus_tag="Rv3032A"
/product="Conserved protein"
/note="Rv3032A, len: 129 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv3032A"
/db_xref="EnsemblGenomes-Tr:CCP45841"
/db_xref="UniProtKB/TrEMBL:I6X630"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45841.1"
/translation="MKPQDQGLHFPYRYDLRLAPMWLPFRWPGSQGVTVTEDGRFVAR
YGPFRVEAPLSSVRDAHITGPYRWWTAVGPRLSMVDDGLTFGTNAAAGVCIHFEPRIH
RVIGLRDHSALTVTVADPEGLVAALSS"
gene 3393380..3393928
/locus_tag="Rv3033"
CDS 3393380..3393928
/codon_start=1
/transl_table=11
/locus_tag="Rv3033"
/product="Unknown protein"
/note="Rv3033, (MTV012.48), len: 182 aa. Unknown protein.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3033"
/db_xref="EnsemblGenomes-Tr:CCP45842"
/db_xref="InterPro:IPR025637"
/db_xref="UniProtKB/TrEMBL:I6YAY5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45842.1"
/translation="MAHSIVRTLLASGAATALIAIPTACSFSIGTSHSHSVSKAEVAR
QITAKMTDAAGNKPESVTCPSDLPAEVGAELNCEMKIKDRTFNVNVTVTSVDGSDVKF
DMVETVDKNQVANIISDKLFQRVGARPDSVTCPDNLKGVEGAKLRCRLTDGSKTYGIS
VIVTSVDAGDVNFDFKVDDHPE"
gene complement(3394019..3394921)
/locus_tag="Rv3034c"
CDS complement(3394019..3394921)
/codon_start=1
/transl_table=11
/locus_tag="Rv3034c"
/product="Possible transferase"
/note="Rv3034c, (MTV012.49c), len: 300 aa. Possible
transferase (2.-.-.-), equivalent to AAK47449|MT3119
Hexapeptide transferase family protein from M.
tuberculosis strain CDC1551 but N-terminus shorter 39
residues (262 aa),FASTA scores: opt: 1773, E(): 4.7e-105,
(100.0% identity in 262 aa overlap). Similar to
Q9CBR1|ML1719 from Mycobacterium leprae but also shorter
in N-terminus (245 aa), FASTA scores: opt: 1549, E():
6.6e-91, (90.6% identity in 244 aa overlap). Some weakly
similarity with other transferases (C-terminal part shows
some similarity to acetyltransferase from Methanococcus
jannaschii (214 aa)). Alternative start possible at
3395077 but codon usage not as good."
/db_xref="EnsemblGenomes-Gn:Rv3034c"
/db_xref="EnsemblGenomes-Tr:CCP45843"
/db_xref="GOA:O53281"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR011004"
/db_xref="UniProtKB/Swiss-Prot:O53281"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45843.1"
/translation="MNVLSLGSSSGVVWGRVPITAPAGAATGVTSRADAHSQMRRYAQ
TGPTAKLSSAPMTTMWGAPLHRRWRGSRLRDPRQAKFLTLASLKWVLANRAYTPWYLV
RYWRLLRFKLANPHIITRGMVFLGKGVEIHATPELAQLEIGRWVHIGDKNTIRAHEGS
LRFGDKVVLGRDNVINTYLDIEIGDSVLMADWCYICDFDHRMDDITLPIKDQGIIKSP
VRIGPDTWIGVKVSVLRGTTIGRGCVLGSHAVVRGAIPDYSIAVGAPAKVVKNRQLSW
EASAAQRAELAAALADIERKKAAR"
gene 3395379..3396461
/locus_tag="Rv3035"
CDS 3395379..3396461
/codon_start=1
/transl_table=11
/locus_tag="Rv3035"
/product="Conserved protein"
/note="Rv3035, (MTV012.50), len: 360 aa. Conserved
protein,equivalent to Q9CBR0|ML1720 hypothetical protein
from Mycobacterium leprae (364 aa), FASTA scores: opt:
1963,E(): 1.4e-108, (75.8% identity in 363 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3035"
/db_xref="EnsemblGenomes-Tr:CCP45844"
/db_xref="InterPro:IPR002372"
/db_xref="InterPro:IPR011047"
/db_xref="InterPro:IPR015943"
/db_xref="UniProtKB/Swiss-Prot:I6XFZ8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45844.1"
/translation="MAAGPALSARGYLALNGQTPAGCSLMEWQNDNNGRQRWCVRLVQ
GGGFAGPLFDGFDNLYVGQPGAIISFPPTQWTRWRQPVIGMPSTPRFLGHGRLLVSTH
LGQLLVFDTRRGMVVGSPVDLVDGIDPTDATRGLADCAPARPGCPVAAAPAFSSVNGT
VVVSVWQPGEPAAKLVGLKYHAEQLVREWTSDAVSAGVLASPVLSADGSTVYVNGRDH
RLWALNAADGKAKWSAPLGFLAQTPPALTPHGLIVSGGGPDTALAAFRDAGDHAEGAW
RRDDVTALSTASLAGTGVGYTVISGPNHDGTPGLSLLVFDPANGHTVNSYPLPGATGY
PVGVSVGNDRRVVTATSDGQVYSFAP"
gene complement(3396458..3397141)
/gene="TB22.2"
/locus_tag="Rv3036c"
CDS complement(3396458..3397141)
/codon_start=1
/transl_table=11
/gene="TB22.2"
/locus_tag="Rv3036c"
/product="Probable conserved secreted protein TB22.2"
/note="Rv3036c, (MTV012.51c), len: 227 aa. Probable
TB22.2,conserved secreted protein, with putative
N-terminal signal peptide, highly similar to secreted
immunogenic protein MPT64/MPB64 P19996|Rv1980c|MTCY39.39
from Mycobacterium tuberculosis and Mycobacterium bovis
(228 aa), FASTA scores: opt: 681, E(): 2.5e-35, (45.8%
identity in 227 aa overlap). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3036c"
/db_xref="EnsemblGenomes-Tr:CCP45845"
/db_xref="InterPro:IPR021729"
/db_xref="InterPro:IPR037126"
/db_xref="UniProtKB/TrEMBL:I6YF08"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45845.1"
/translation="MRYLIATAVLVAVVLVGWPAAGAPPSCAGLGGTVQAGQICHVHA
SGPKYMLDMTFPVDYPDQQALTDYITQNRDGFVNVAQGSPLRDQPYQMDATSEQHSSG
QPPQATRSVVLKFFQDLGGAHPSTWYKAFNYNLATSQPITFDTLFVPGTTPLDSIYPI
VQRELARQTGFGAAILPSTGLDPAHYQNFAITDDSLIFYFAQGELLPSFVGACQAQVP
RSAIPPLAI"
gene complement(3397214..3398290)
/locus_tag="Rv3037c"
CDS complement(3397214..3398290)
/codon_start=1
/transl_table=11
/locus_tag="Rv3037c"
/product="Conserved hypothetical protein"
/note="Rv3037c, (MTV012.52c), len: 358 aa. Conserved
hypothetical protein, similar in part to others e.g.
O86799|SC6G4.36c from Streptomyces coelicolor (426
aa),FASTA scores: opt: 545, E(): 5.5e-27, (36.15% identity
in 354 aa overlap); Q9UZW6|PAB0687 from Pyrococcus abyssi
(386 aa), FASTA scores: opt: 262, E(): 3.5e-09, (31.0%
identity in 200 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3037c"
/db_xref="EnsemblGenomes-Tr:CCP45846"
/db_xref="GOA:P9WJZ3"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041497"
/db_xref="UniProtKB/Swiss-Prot:P9WJZ3"
/protein_id="CCP45846.1"
/translation="MRARFGDRAPWLVETTLLRRRAAGKLGELCPNVGVSQWLFTDEA
LQQATAAPVARHRARRLAGRVVHDATCSIGTELAALRELAVRAVGSDIDPVRLAMARH
NLAALGMEADLCRADVLHPVTRDAVVVIDPARRSNGRRRFHLADYQPGLGPLLDRYRG
RDVVVKCAPGIDFEEVGRLGFEGEIEVISYRGGVREACLWSAGLAGSGIRRRASILDS
GEQIGDDEPDDCGVRPAGKWIVDPDGAVVRAGLVRNYGARHGLWQLDPQIAYLSGDRL
PPALRGFEVLEQLAFDERRLRQVLSALDCGAAEILVRGVAIDPDALRRRLRLRGSRPL
AVVITRIGAGSLSHVTAYVCRPSR"
gene complement(3398425..3399408)
/locus_tag="Rv3038c"
CDS complement(3398425..3399408)
/codon_start=1
/transl_table=11
/locus_tag="Rv3038c"
/product="Conserved protein"
/note="Rv3038c, (MTV012.53c), len: 327 aa. Conserved
protein, equivalent to Q9CBQ9|ML1723 hypothetical protein
from Mycobacterium leprae (327 aa), FASTA scores: opt:
1843, E(): 6.1e-108, (80.75% identity in 327 aa overlap).
Weak similarity with e.g. Q9KZI3|SCG8A.16 putative
methyltransferase from Streptomyces coelicolor (199
aa),FASTA scores: opt: 227, E(): 3.9e-07, (31.95% identity
in 191 aa overlap) and O52570 methyltransferase from
Amycolatopsis mediterranei (272 aa), FASTA scores: opt:
228, E(): 4.3e-07, (31.7% identity in 164 aa overlap).
Contains PS00044 Bacterial regulatory proteins, lysR
family signature but shows no similarity to known LysR
family members."
/db_xref="EnsemblGenomes-Gn:Rv3038c"
/db_xref="EnsemblGenomes-Tr:CCP45847"
/db_xref="GOA:I6YAZ1"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:I6YAZ1"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45847.1"
/translation="MTRSSNIPADATPNPHATAEQVAAARHDSKLAQVLYHDWEAENY
DEKWSISYDQRCVDYARGRFDAIVPDEVIAQLPYDRALELGCGTGFFLLNLIQAGVAR
RGSVTDLSPGMVKVATRNGQALGLDIDGRVADAEGIPYDDDAFDLVVGHAVLHHIPDV
ELSLREVVRVLKPGGRFVFAGEPTTVGDGYARTLSTLTWRVVTNATKLPGLRGWRRPQ
GELDESSRAAALEALVDLHTFTPQDLQRIAHNAGAVEVQTATEEFTAAMLGWPLRTFE
CTVPPGRLGWGWARFAFTSWKTLGWVDANVWRHVVPKGWFYNVMITGVKPS"
gene complement(3399419..3400183)
/gene="echA17"
/locus_tag="Rv3039c"
CDS complement(3399419..3400183)
/codon_start=1
/transl_table=11
/gene="echA17"
/locus_tag="Rv3039c"
/product="Probable enoyl-CoA hydratase EchA17 (crotonase)
(unsatured acyl-CoA hydratase) (enoyl hydrase)"
/note="Rv3039c, (MTV012.54c), len: 254 aa. Probable
echA17,Enoyl-CoA Hydratase/Isomerase Superfamily member
(crotonase). Similar to many e.g. Q9L1E6|SC3D11.16
putative enoyl-CoA hydratase from Streptomyces coelicolor
(255 aa),FASTA scores: opt: 625, E(): 1.5e-30, (45.55%
identity in 224 aa overlap);
O07137||ECH8_MYCLE|ML2402|MLCB1306.05c probable enoyl-CoA
hydratase ECHA8 from Mycobacterium leprae (257 aa), FASTA
scores: opt: 448, E(): 6.4e-20,(35.3% identity in 235 aa
overlap), P97087|CRT crotonase / enoyl-CoA hydratase from
Clostridium thermosaccharolyticum (Thermoanaerobacterium
thermosaccharolyticum) (259 aa),FASTA scores: opt: 420,
E(): 3.1e-18, (31.2% identity in 234 aa overlap). Also
similar to Mycobacterium tuberculosis
AAK45356|O53418|Rv1070c|ECHA8|MT1100|MTV017.23c probable
enoyl-CoA hydratase ECHA8 (257 aa), FASTA scores: opt:
450,E(): 4.9e-20, (36.4% identity in 226 aa overlap).
Belongs to the enoyl-CoA hydratase/isomerase family."
/db_xref="EnsemblGenomes-Gn:Rv3039c"
/db_xref="EnsemblGenomes-Tr:CCP45848"
/db_xref="GOA:P9WNN3"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/Swiss-Prot:P9WNN3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45848.1"
/translation="MPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAAN
ELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEADTAARIRQQAVDAVAAIPKPT
VAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRA
KELVFSGRFFDAEEALALGLIDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISD
VYELAPAERIAAERRRYVEVFAAGQGGGSKGDRGGR"
gene complement(3400192..3401058)
/locus_tag="Rv3040c"
CDS complement(3400192..3401058)
/codon_start=1
/transl_table=11
/locus_tag="Rv3040c"
/product="Conserved protein"
/note="Rv3040c, (MTV012.55c), len: 288 aa. Conserved
protein, highly similar to Q9XA40|SCH17.07c hypothetical
protein from Streptomyces coelicolor (312 aa), FASTA
scores: opt: 648, E(): 5.2e-34, (50.0% identity in 260 aa
overlap). Also similar to Q9F7R7 predicted mutt
superfamily hydrolase from uncultured proteobacterium
EBAC31A08 (264 aa), FASTA scores: opt: 295, E(): 1.3e-11,
(27.2% identity in 257 aa overlap); AAK24293|CC2322
hypothetical protein from Caulobacter crescentus (254 aa),
blast scores: 185 (32% identity) and 131 (37% identity),
etc."
/db_xref="EnsemblGenomes-Gn:Rv3040c"
/db_xref="EnsemblGenomes-Tr:CCP45849"
/db_xref="GOA:O53287"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR039121"
/db_xref="UniProtKB/TrEMBL:O53287"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45849.1"
/translation="MNSPREPLVPPPTPRPAATVMLVRDPDAGSASGLAVFLMRRHAA
MDFAAGVMVFPGGGVDDRDRDADLGRLGAWAGPPPQWWAQRFGIEPDLAEALVCAAAR
ETFEESGVLFAGPVDQDHSAPNSIVSDASVYGDARRALADRTLSFADFLQREKLVLRS
DLLRPWANWVTPEAELTRRYDTYFFVGALPEGQRADGENTESDRAGWVLPADAIADFA
AGRNFLLPPTWTQLDSLAGHTVADVLAVERQIVPVQPQLARNGDNWEIEFFDSDRYNQ
ARRSGGSTGWPL"
gene complement(3401055..3401918)
/locus_tag="Rv3041c"
CDS complement(3401055..3401918)
/codon_start=1
/transl_table=11
/locus_tag="Rv3041c"
/product="Probable conserved ATP-binding protein ABC
transporter"
/note="Rv3041c, (MTV012.56c), len: 287 aa. Probable
conserved ATP-binding protein ABC transporter (see
citation below), equivalent to Q9CBQ7|ML1726 putative ABC
transporter protein ATP-binding protein from Mycobacterium
leprae (305 aa), FASTA scores: opt: 1576, E():
8.6e-85,(83.4% identity in 289 aa overlap). Also similar
to other putative ATP-binding proteins ABC transporters
e.g. Q9X9Z4|SCI5.06C from Streptomyces coelicolor (265
aa),FASTA scores: opt: 893, E(): 4.8e-45, (53.3% identity
in 257 aa overlap); Q9L156|SC5C11.16c from Streptomyces
coelicolor (279 aa), FASTA scores: opt: 680, E():
1.3e-32,(45.4% identity in 271 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv3041c"
/db_xref="EnsemblGenomes-Tr:CCP45850"
/db_xref="GOA:I6YF11"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:I6YF11"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45850.1"
/translation="MRHDSRVLDNGGPDAADPDLLIDFRNVSLRRNGRTLVGPLDWAV
ELDERWVIVGPNGAGKTSLLRIAAAAEHPSSGVAFVLGERLGRVDVSELRARVGLSSS
ALAERVPGDERVRDLVVSAGYAVLGRWRERYEAVDYHRAIDMLESLGAEHLANRTYGT
LSEGERKRVLIARALMTDPELLLLDEPAAGLDLGGREELVARLADLAADPDAPALVLV
THHVEEIPPGFSHCLLLSEARVVAAGLLPDALTAENLSTAFGQEITLEVADGRYFARR
RRSRAAHRRQS"
gene complement(3401933..3403162)
/gene="serB2"
/locus_tag="Rv3042c"
CDS complement(3401933..3403162)
/codon_start=1
/transl_table=11
/gene="serB2"
/locus_tag="Rv3042c"
/product="Probable phosphoserine phosphatase SerB2 (PSP)
(O-phosphoserine phosphohydrolase) (pspase)"
/note="Rv3042c, (MTV012.57c), len: 409 aa. Probable
serB2,Phosphoserine phosphatase, equivalent to
Q9CBQ6|ML1727 putative phosphoserine phosphatase from
Mycobacterium leprae (411 aa), FASTA scores: opt: 2173,
E(): 1.3e-117,(86.3% identity in 408 aa overlap). Also
similar to other e.g. Q9S281|SCI28.02 from Streptomyces
coelicolor (410 aa),FASTA scores: opt: 1209, E(): 3e-62,
(51.75% identity in 400 aa overlap); Q9HUK|PA4960 from
Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 704,
E(): 3.1e-33, (40.95% identity in 393 aa overlap);
O28142|SERB_ARCTU|AF2138 from Archaeoglobus fulgidus (344
aa), FASTA scores: opt: 671,E(): 2e-31, (37.25% identity
in 325 aa overlap); and P06862|SERB_ECOLI (322 aa), FASTA
scores: opt: 628, E(): 5.7e-29, (46.8% identity in 235 aa
overlap). Belongs to the SerB family."
/db_xref="EnsemblGenomes-Gn:Rv3042c"
/db_xref="EnsemblGenomes-Tr:CCP45851"
/db_xref="GOA:O53289"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR023190"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:O53289"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45851.1"
/translation="MPAKVSVLITVTGMDQPGVTSALFEVLAQHGVELLNVEQVVIRG
RLTLGVLVSCPLDVADGTALRDDVAAAIHGVGLDVAIERSDDLPIIRQPSTHTIFVLG
RPITAGAFSAVARGVAALGVNIDFIRGISDYPVTGLELRVSVPPGCVGPLQIALTKVA
AEEHVDVAVEDYGLAWRTKRLIVFDVDSTLVQGEVIEMLAARAGAQGQVAAITEAAMR
GELDFAESLQRRVATLAGLPATVIDDVAEQLELMPGARTTIRTLRRLGFRCGVVSGGF
RRIIEPLARELMLDFVASNELEIVDGILTGRVVGPIVDRPGKAKALRDFASQYGVPME
QTVAVGDGANDIDMLGAAGLGIAFNAKPALREVADASLSHPYLDTVLFLLGVTRGEIE
AADAGDCGVRRVEIPAD"
gene complement(3403200..3404921)
/gene="ctaD"
/locus_tag="Rv3043c"
CDS complement(3403200..3404921)
/codon_start=1
/transl_table=11
/gene="ctaD"
/locus_tag="Rv3043c"
/product="Probable cytochrome C oxidase polypeptide I CtaD
(cytochrome AA3 subunit 1)"
/note="Rv3043c, (MTV012.58c), len: 573 aa. Probable
ctaD,integral membrane cytochrome C oxidase polypeptide
I,equivalent to Q9CBQ5|ML1728 from Mycobacterium leprae
(574 aa), FASTA scores: opt: 3738, E(): 3.8e-216, (95.4%
identity in 566 aa overlap). Also similar to other
cytochrome C oxidases polypeptide I e.g. Q9AEL9|CTAD from
Corynebacterium glutamicum (Brevibacterium flavum) (584
aa), FASTA scores: opt: 3065, E(): 6.8e-176, (72.65%
identity in 567 aa overlap); Q9X813|SC6G10.28c from
Streptomyces coelicolor (578 aa), FASTA scores: opt:
2888,E(): 2.6e-165, (71.7% identity in 544 aa overlap);
Q9K451|CTAD from Streptomyces coelicolor (573 aa), FASTA
scores: opt: 2757, E(): 1.8e-157, (70.2% identity in 537
aa overlap). Contains PS00077 Cytochrome c oxidase subunit
I,copper B binding region signature. Belongs to the
heme-copper respiratory oxidase family."
/db_xref="EnsemblGenomes-Gn:Rv3043c"
/db_xref="EnsemblGenomes-Tr:CCP45852"
/db_xref="GOA:P9WP71"
/db_xref="InterPro:IPR000883"
/db_xref="InterPro:IPR014241"
/db_xref="InterPro:IPR023615"
/db_xref="InterPro:IPR023616"
/db_xref="InterPro:IPR036927"
/db_xref="UniProtKB/Swiss-Prot:P9WP71"
/inference="protein motif:PROSITE:PS00077"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45852.1"
/translation="MTAEAPPLGELEAIRPYPARTGPKGSLVYKLITTTDHKMIGIMY
CVACISFFFIGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVFGF
ANLVLPLQIGAPDVAFPRLNAFSFWLFVFGATIGAAGFITPGGAADFGWTAYTPLTDA
IHSPGAGGDLWIMGLIVAGLGTILGAVNMITTVVCMRAPGMTMFRMPIFTWNIMVTSI
LILIAFPLLTAALFGLAADRHLGAHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFG
IVSEIFPVFSRKPIFGYTTLVYATLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIA
VPTGIKFFNWIGTMWKGQLTFETPMLFSVGFMVTFLLGGLTGVLLASPPLDFHVTDSY
FVVAHFHYVLFGTIVFATFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQH
WLGDEGMPRRYADYLPTDGFQGLNVVSTIGAFILGASMFPFVWNVFKSWRYGEVVTVD
DPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRAEAHVGRHHDE
PAMVTSS"
gene 3405136..3406215
/gene="fecB"
/locus_tag="Rv3044"
CDS 3405136..3406215
/codon_start=1
/transl_table=11
/gene="fecB"
/locus_tag="Rv3044"
/product="Probable FEIII-dicitrate-binding periplasmic
lipoprotein FecB"
/note="Rv3044, (MTV012.59), len: 359 aa. Probable
fecB,FeIII dicitrate-binding periplasmic lipoprotein (see
citation below), equivalent to Q9CBQ4|FECB|ML1729 putative
FEIII-dicitrate transporter lipoprotein from Mycobacterium
leprae (364 aa), FASTA scores: opt: 1816, E():
1.1e-96,(75.65% identity in 357 aa overlap); and
Q9LA57|FECB from Mycobacterium avium (364 aa), FASTA
scores: opt: 1769, E(): 5.1e-94. Similar to many
periplasmic FeIII-dicitrate transporters e.g.
P72593|FECB|SLR1319 from Synechocystis sp. strain PCC 6803
(315 aa), FASTA scores: opt: 459, E(): 3.6e-19, (31.35%
identity in 303 aa overlap); and P72611|FECB|SLR1492 from
Synechocystis sp. strain PCC 6803. N-terminus longer
(approximately 30 aa) to AAK47459 from Mycobacterium
tuberculosis strain CDC1551 (327 aa). Has signal peptide
and appropriately positioned PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3044"
/db_xref="EnsemblGenomes-Tr:CCP45853"
/db_xref="GOA:O53291"
/db_xref="InterPro:IPR002491"
/db_xref="UniProtKB/TrEMBL:O53291"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45853.1"
/translation="MRSTVAVAVAAAVIAASSGCGSDQPAHKASQSMITPTTQIAGAG
VLGNDRKPDESCARAAAAADPGPPTRPAHNAAGVSPEMVQVPAEAQRIVVLSGDQLDA
LCALGLQSRIVAAALPNSSSSQPSYLGTTVHDLPGVGTRSAPDLRAIAAAHPDLILGS
QGLTPQLYPQLAAIAPTVFTAAPGADWENNLRGVGAATARIAAVDALITGFAEHATQV
GTKHDATHFQASIVQLTANTMRVYGANNFPASVLSAVGVDRPPSQRFTDKAYIEIGTT
AADLAKSPDFSAADADIVYLSCASEAAAERAAVILDSDPWRKLSANRDNRVFVVNDQV
WQTGEGMVAARGIVDDLRWVDAPIN"
gene 3406285..3407325
/gene="adhC"
/locus_tag="Rv3045"
CDS 3406285..3407325
/codon_start=1
/transl_table=11
/gene="adhC"
/locus_tag="Rv3045"
/product="Probable NADP-dependent alcohol dehydrogenase
AdhC"
/note="Rv3045, (MTV012.60), len: 346 aa. Probable
adhC,NADP-dependent alcohol dehydrogenase, equivalent to
Q9CBQ3|ADHA|ML1730 alcohol dehydrogenases from
Mycobacterium leprae (362 aa), FASTA scores: opt:
1982,E(): 1.3e-111, (85.85% identity in 346 aa overlap);
Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA
scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347
aa overlap); Q9EWF1|SCK13.33c putative dehydrogenase from
Streptomyces coelicolor (346 aa), FASTA scores: opt:
1508,E(): 3.3e-83, (64.45% identity in 346 aa overlap);
O06007|ADHA from Bacillus subtilis (349 aa), FASTA scores:
opt: 1412, E(): 1.9e-77, (61.8% identity in 335 aa
overlap); etc. Contains PS00059 Zinc-containing alcohol
dehydrogenases signature. Belongs to the zinc-containing
alcohol dehydrogenase family. High similarity with other
bacterial ADH'S."
/db_xref="EnsemblGenomes-Gn:Rv3045"
/db_xref="EnsemblGenomes-Tr:CCP45854"
/db_xref="GOA:P9WQC5"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WQC5"
/inference="protein motif:PROSITE:PS00059"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45854.1"
/translation="MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSD
IHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYRQGDRVGVGCFVDSCRECNSCTR
GIEQYCKPGANFTYNSIGKDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAG
ITLYSPLRHWNAGANTRVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLG
AKSYYATADPDTFRKLRGGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAV
PAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDYINDAYERVLASD
VRYRFVIDISAL"
gene complement(3407314..3407688)
/locus_tag="Rv3046c"
CDS complement(3407314..3407688)
/codon_start=1
/transl_table=11
/locus_tag="Rv3046c"
/product="Conserved protein"
/note="Rv3046c, (MTV012.61c), len: 124 aa. Conserved
protein, similar to several hypothetical mycobacterial
proteins e.g. Q50171|ML2258 U296W hypothetical protein
from Mycobacterium leprae (100 aa), FASTA scores: opt:
194, E(): 7.6e-06, (35.9% identity in 103 aa overlap); and
O06409|Rv0543c|MTCY25D10.22c from Mycobacterium
tuberculosis (100 aa), FASTA scores: opt: 192, E():
1e-05,(34.7% identity in 98 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3046c"
/db_xref="EnsemblGenomes-Tr:CCP45855"
/db_xref="InterPro:IPR021784"
/db_xref="UniProtKB/TrEMBL:I6YF16"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45855.1"
/translation="MTKTFSHPHFFRSVLRWLQVGYPEGVPGPDRVALLSLLRSTPLT
EEQIGEVVRHFTENGSPAVADRVIDRDEIAEFISEVTHHDAGPENIQRVAGILAAAGW
PLAGVDVGESESGSDRAPASQG"
gene complement(3408022..3408306)
/locus_tag="Rv3047c"
CDS complement(3408022..3408306)
/codon_start=1
/transl_table=11
/locus_tag="Rv3047c"
/product="Hypothetical protein"
/note="Rv3047c, (MTV012.62c), len: 94 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3047c"
/db_xref="EnsemblGenomes-Tr:CCP45856"
/db_xref="UniProtKB/TrEMBL:I6X642"
/protein_id="CCP45856.1"
/translation="MGGPFDADAEAHFDEVAEAFAKLTNVDRDVGVDLEKELCMTVEA
DDRSDALVTRRLLPRVPRCIPLAARLAPGTIGCPSFWNPIATGGASRQAL"
gene complement(3408404..3409378)
/gene="nrdF2"
/gene_synonym="nrdG"
/locus_tag="Rv3048c"
CDS complement(3408404..3409378)
/codon_start=1
/transl_table=11
/gene="nrdF2"
/gene_synonym="nrdG"
/locus_tag="Rv3048c"
/product="Ribonucleoside-diphosphate reductase (beta
chain) NrdF2 (ribonucleotide reductase small subunit) (R2F
protein)"
/note="Rv3048c, (MTV012.63c), len: 324 aa.
NrdF2,ribonucleoside-diphosphate reductase, beta chain
(see citation below), equivalent to
Q9CBQ2|RIR2_MYCL|NRDF|ML1731 ribonucleoside-diphosphate
reductase beta chain from Mycobacterium leprae (325 aa),
FASTA scores: opt: 2009,E(): 1.3e-123, (93.5% identity in
324 aa overlap). Also similar to other
ribonucleoside-diphosphate reductases e.g. Q9XD62|NRDF
from Corynebacterium glutamicum (Brevibacterium flavum)
(334 aa), FASTA scores: opt: 1648, E(): 4.2e-100,(78.35%
identity in 314 aa overlap); O69274|NRDF from
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
(329 aa), FASTA scores: opt: 1626, E(): 1.1e-98, (75.3%
identity in 320 aa overlap); P37146|NRDF|B2676 from
Escherichia coli (319 aa), FASTA scores: opt: 1569, E():
5.7e-95, (71.3% identity in 317 aa overlap). Contains
PS00368 Ribonucleotide reductase small subunit signature.
Belongs to the ribonucleoside diphosphate reductase small
chain family. Cofactor: binds 2 iron ions (by similarity).
Note that previously known as nrdG."
/db_xref="EnsemblGenomes-Gn:Rv3048c"
/db_xref="EnsemblGenomes-Tr:CCP45857"
/db_xref="GOA:P9WH71"
/db_xref="InterPro:IPR000358"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012348"
/db_xref="InterPro:IPR026494"
/db_xref="InterPro:IPR030475"
/db_xref="InterPro:IPR033909"
/db_xref="PDB:1UZR"
/db_xref="UniProtKB/Swiss-Prot:P9WH71"
/inference="protein motif:PROSITE:PS00368"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45857.1"
/translation="MTGNAKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVS
NDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFM
ESVHAKSYSQIFSTLCSTAEIDDAFRWSEENRNLQRKAEIVLQYYRGDEPLKRKVAST
LLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLALVDDV
TRAELKDYTYELLFELYDNEVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALF
PRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTEDDDWDF"
gene complement(3409509..3411083)
/locus_tag="Rv3049c"
CDS complement(3409509..3411083)
/codon_start=1
/transl_table=11
/locus_tag="Rv3049c"
/product="Probable monooxygenase"
/note="Rv3049c, (MTV012.64c), len: 524 aa. Probable
monooxygenase, similar to several monooxygenases e.g.
Q9I3H5|PA1538 probable flavin-containing monooxygenase
from Pseudomonas aeruginosa (527 aa), FASTA scores: opt:
1577,E(): 3.9e-90, (47.3% identity in 501 aa overlap);
Q9RKB5|SCE87.23c monooxygenase from Streptomyces
coelicolor (519 aa), FASTA scores: opt: 1522, E():
9.8e-87, (47.4% identity in 485 aa overlap); Q9I218|PA2097
probable flavin-binding monooxygenase from Pseudomonas
aeruginosa (491 aa), FASTA scores: opt: 1366, E():
4.2e-77, (43.75% identity in 489 aa overlap); etc. Also
similar to Q10532|Rv0892|Y892_MYCTU|MT0916|MTCY31.20
probable monooxygenase from Mycobacterium tuberculosis
strain H37Rv (495 aa), FASTA scores: opt: 1147, E():
1.5e-63, (38.0% identity in 479 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3049c"
/db_xref="EnsemblGenomes-Tr:CCP45858"
/db_xref="GOA:I6Y2E2"
/db_xref="InterPro:IPR020946"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:I6Y2E2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45858.1"
/translation="MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQ
GVDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWDEILGYL
KGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGREYVAQFLISGAGALHIPSF
PEIAGRDEFAGPAFHSAQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQR
TPPWVVPRTNEELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEA
YAKYNIRRSVKDRELRRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRIDRITHD
GIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNREGIGAHRG
ITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGVQALAPTREAQD
RFNQELQRRLAGSVWNSGGCRSWYLDEHGKNTVLWCGYTWQYWLTTRSVNPAEYRFFG
IGNGLSSDRATVAAAN"
gene complement(3411217..3411957)
/locus_tag="Rv3050c"
CDS complement(3411217..3411957)
/codon_start=1
/transl_table=11
/locus_tag="Rv3050c"
/product="Probable transcriptional regulatory protein
(probably AsnC-family)"
/note="Rv3050c, (MTV012.65c), len: 246 aa. Probable
transcriptional regulatory protein TetR-family, equivalent
but shorter to Q9CBQ1|ML1733 from Mycobacterium leprae
(275 aa), FASTA scores: opt: 1381,(E): 2.7e-79, (86.25%
identity in 240 aa overlap); AAK44712|MT0489 from
Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA
scores: opt: 328,(E): 1.8e-13, (30.75% identity in 234 aa
overlap); etc. Also some similarity to
O53757|Rv0472c|MTV038.16c. Alternative starts possible at
68052 or 67923. Has potential helix-turn-helix motif at
positons 51-72."
/db_xref="EnsemblGenomes-Gn:Rv3050c"
/db_xref="EnsemblGenomes-Tr:CCP45859"
/db_xref="GOA:I6XG13"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:I6XG13"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45859.1"
/translation="MVRIPRPHPSAKPGVKVDARSERWREHRKKVRNEIVDAAFRAID
RLGPELSVRQIAEEAGTAKPKIYRHFTDKSDLLEAIGMRLRDMLWAAIFPSLDLATDS
AREVIRRSVEEYVNLVDQHPNVLRVFIQGRSAKQSEATVRTLNEGREITLAMAEMFNN
ELREMELNRAALELAAFAAFGSAASATEWWLGPEPDSPRRMPREQFVAHLTTIMMGVI
VGTAEALGIAVDPDQPIHDAVPNNPAVR"
gene complement(3412085..3414166)
/gene="nrdE"
/locus_tag="Rv3051c"
CDS complement(3412085..3414166)
/codon_start=1
/transl_table=11
/gene="nrdE"
/locus_tag="Rv3051c"
/product="Ribonucleoside-diphosphate reductase (alpha
chain) NrdE (ribonucleotide reductase small subunit) (R1F
protein)"
/note="Rv3051c, (MTV012.66c), len: 693 aa.
NrdE,ribonucleotide-diphosphate reductase, alpha chain
(see citations below), equivalent to Q9CBQ0|NRDE|ML1734
from Mycobacterium leprae (693 aa), FASTA scores: opt:
4259,E(): 0, (93.2% identity in 693 aa overlap). Similar
to other Ribonucleoside-diphosphate reductases e.g.
Q9XD63|NRDE from Corynebacterium glutamicum
(Brevibacterium flavum) (707 aa), FASTA scores: opt:
3683,E(): 0, (79.35% identity in 693 aa overlap);
O69273|NRDE from Corynebacterium ammoniagenes
(Brevibacterium ammoniagenes) (720 aa), FASTA scores: opt:
3555, E(): 1.7e-214, (76.1% identity in 694 aa overlap);
P39452|NRDE|B2675 from Escherichia coli (713 aa),FASTA
scores: opt: 3430, E(): 1.1e-206, (73.6% identity in 693
aa overlap); etc. Equivalent to AAK47468|MT3137 from
Mycobacterium tuberculosis strain CDC1551 (725 aa) but
shorter in N-terminus. Contains PS00089 Ribonucleotide
reductase large subunit signature. Belongs to the
ribonucleoside diphosphate reductase large chain family."
/db_xref="EnsemblGenomes-Gn:Rv3051c"
/db_xref="EnsemblGenomes-Tr:CCP45860"
/db_xref="GOA:P9WH75"
/db_xref="InterPro:IPR000788"
/db_xref="InterPro:IPR008926"
/db_xref="InterPro:IPR013346"
/db_xref="InterPro:IPR013509"
/db_xref="InterPro:IPR013554"
/db_xref="InterPro:IPR026459"
/db_xref="InterPro:IPR039718"
/db_xref="UniProtKB/Swiss-Prot:P9WH75"
/inference="protein motif:PROSITE:PS00089"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45860.1"
/translation="MLNLYDADGKIQFDKDREAAHQYFLQHVNQNTVFFHNQDEKLDY
LIRENYYEREVLDQYSRNFVKTLLDRAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYL
ERFEDRVVMVALTLAAGDTALAELLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLL
RVEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSSGVIPIMKLLE
DAFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITF
ELAKRNDDMYLFSPYDVERVYGVPFADISVTEKYYEMVDDARIRKTKIKAREFFQTLA
ELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNEDLSYAKVGKDI
SCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQ
MNLHGYLARERIFYGSDEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYA
SGEFFDKYTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQNLQAVP
PTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYEDAYEIGYEK
IIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEG
TEVEGCVSCML"
gene complement(3414232..3414684)
/gene="nrdI"
/locus_tag="Rv3052c"
CDS complement(3414232..3414684)
/codon_start=1
/transl_table=11
/gene="nrdI"
/locus_tag="Rv3052c"
/product="Probable NrdI protein"
/note="Rv3052c, (MTCY22D7.30), len: 150 aa. Probable
nrdI,equivalent to Q9CBP9|NRDI|ML1735 from Mycobacterium
leprae (138 aa), FASTA scores: opt: 765, E(): 3.8e-44,
(79.7% identity in 138 aa overlap), and similar to many
NRDI proteins e.g. Q47415|NRDI_ECOLI|B2674 from
Escherichia coli (136 aa), FASTA scores: opt: 574, E():
1.9e-31, (62.2% identity in 135 aa overlap). Belongs to
the NRDI family."
/db_xref="EnsemblGenomes-Gn:Rv3052c"
/db_xref="EnsemblGenomes-Tr:CCP45861"
/db_xref="GOA:P9WIZ3"
/db_xref="InterPro:IPR004465"
/db_xref="InterPro:IPR020852"
/db_xref="InterPro:IPR029039"
/db_xref="UniProtKB/Swiss-Prot:P9WIZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45861.1"
/translation="MDIAGRSLVYFSSVSENTHRFVQKLGIPATRIPLHGRIEVDEPY
VLILPTYGGGRANPGLDAGGYVPKQVIAFLNNDHNRAQLRGVIAAGNTNFGAEFCYAG
DVVSRKCSVPYLYRFELMGTEDDVAAVRTGLAEFWKEQTCHQPSLQSL"
gene complement(3414719..3414958)
/gene="nrdH"
/locus_tag="Rv3053c"
CDS complement(3414719..3414958)
/codon_start=1
/transl_table=11
/gene="nrdH"
/locus_tag="Rv3053c"
/product="Probable glutaredoxin electron transport
component of NRDEF (glutaredoxin-like protein) NrdH"
/note="Rv3053c, (MTCY22D7.29), len: 79 aa. Probable
nrdH,glutaredoxin-like protein, equivalent to
Q9CBP8|NRDH|ML1736 from Mycobacterium leprae (80 aa),
FASTA scores: opt: 478,E(): 2.7e-27, (91.15% identity in
79 aa overlap), and similar to many glutaredoxin-like
proteins e.g. Q9XD65|NRDH from Corynebacterium glutamicum
(Brevibacterium flavum) (77 aa), FASTA scores: opt: 382,
E(): 1.5e-20, (72.35% identity in 76 aa overlap); and
Q56108|NRDH_SALTY from Salmonella typhimurium (81 aa),
FASTA scores: opt: 243, E(): 9.9e-11,(45.85% identity in
72 aa overlap). Belongs to the glutaredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv3053c"
/db_xref="EnsemblGenomes-Tr:CCP45862"
/db_xref="GOA:I6YB06"
/db_xref="InterPro:IPR002109"
/db_xref="InterPro:IPR011909"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:4F2I"
/db_xref="PDB:4K8M"
/db_xref="UniProtKB/TrEMBL:I6YB06"
/protein_id="CCP45862.1"
/translation="MTVTVYTKPACVQCSATSKALDKQGIAYQKVDISLDSEARDYVM
ALGYLQAPVVVAGNDHWSGFRPDRIKALAGAALTA"
gene complement(3415435..3415989)
/locus_tag="Rv3054c"
CDS complement(3415435..3415989)
/codon_start=1
/transl_table=11
/locus_tag="Rv3054c"
/product="Conserved hypothetical protein"
/note="Rv3054c, (MTCY22D7.28), len: 184 aa. Conserved
hypothetical protein, similar to Q9RD22|SCM1.21 putative
secreted protein from Streptomyces coelicolor (187
aa),FASTA scores: opt: 651, E(): 1.5e-33, (56.8% identity
in 175 aa overlap). Also shares similarity with other
hypothetical proteins and Chromate reductases e.g.
AAK56853|CHRR from Pseudomonas putida (186 aa), FASTA
scores: opt: 339, E(): 3.3e-14, (38.75% identity in 160 aa
overlap). Contains aminotransferases class-II
pyridoxal-phosphate attachment site (PS00599) near
C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv3054c"
/db_xref="EnsemblGenomes-Tr:CCP45863"
/db_xref="GOA:P95105"
/db_xref="InterPro:IPR005025"
/db_xref="InterPro:IPR029039"
/db_xref="UniProtKB/TrEMBL:P95105"
/inference="protein motif:PROSITE:PS00599"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45863.1"
/translation="MSDTKSDIKILALVGSLRAASFNRQIAELAAKVAPDGVTVTMFE
GLGDLPFYNEDIDTATEVPAPVSALREAASDAHAALVVTPEYNGSIPAVIKNAIDWLS
RPFGDGALKDKPLAVIGGSMGRYGGVWAHDETRKSFSIAGTRVVDAIKLSVPFQTLGK
SVADDAGLAANVRDAVGNLAAEVG"
gene 3416081..3416695
/locus_tag="Rv3055"
CDS 3416081..3416695
/codon_start=1
/transl_table=11
/locus_tag="Rv3055"
/product="Possible transcriptional regulatory protein
(probably TetR-family)"
/note="Rv3055, (MTCY22D7.26c), len: 204 aa. Possible
transcriptional regulatory protein, similar to
Q9RD23|SCM1.20c putative TetR-family transcriptional
regulator from Streptomyces coelicolor (234 aa), FASTA
scores: opt: 471, E(): 4.6e-23, (44.9% identity in 187 aa
overlap); and with low similarity to other e.g.
Q9ADK8|2SCK31.12 putative TetR-family transcriptional
regulator from Streptomyces coelicolor (198 aa), FASTA
scores: opt: 208, 2.5e-06, (32.9% identity in 155 aa
overlap); Q9ADD9|SCBAC20F6.11c putative TetR-family
transcriptional from Streptomyces coelicolor (199
aa),FASTA scores: opt: 182, E(): 0.00012, (31.0% identity
in 184 aa overlap). Contains potential helix-turn-helix
motif from aa 48 to 69 (+3.42 SD). so may belong to the
TetR/AcrR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3055"
/db_xref="EnsemblGenomes-Tr:CCP45864"
/db_xref="GOA:P95103"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:P95103"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45864.1"
/translation="MSGAERLGDLPVFARQEPVPERGDAARNRALLLEAARRLIARSG
ADAITMDDVAAAAGVGKGTLFRRFGSRAGLMMVLLDEDERASQQAFLFGPPPLGPDAP
PLDRLIAFGRERMRFVHAHHQLLSEANRDPQTRHSAALSVLRTHLRVLLASAPTTGDL
DAQTDALLALLDVDYVEHQLNAGGHTLQTLGDAWESLARKLCGR"
gene 3416705..3417745
/gene="dinP"
/gene_synonym="dinB2"
/locus_tag="Rv3056"
CDS 3416705..3417745
/codon_start=1
/transl_table=11
/gene="dinP"
/gene_synonym="dinB2"
/locus_tag="Rv3056"
/product="Possible DNA-damage-inducible protein P DinP
(DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase
(DNA-directed))"
/note="Rv3056, (MTCY22D7.25c, MT3142), len: 346 aa.
Possible dinP (alternate gene name:
dinB2),DNA-damage-inducible protein (DNA polymerase V)
(see citations below), similar to others e.g.
AAK45855|MT1589 from Mycobacterium tuberculosis strain
CDC1551 (485 aa),FASTA scores: opt: 620, E(): 6.1e-32,
(37.2% identity in 344 aa overlap); BAB49140|MLR1877 from
Rhizobium loti (Mesorhizobium loti) (415 aa), FASTA
scores: opt: 533, E(): 1.8e-26, (34.35% identity in 358 aa
overlap); and BAB54888|MLL9709 from Rhizobium loti
(Mesorhizobium loti) (361 aa), FASTA scores: opt: 532,
E(): 1.8e-26, (35.35% identity in 348 aa overlap).
Extensive similarity to proteins induced by DNA damage
such as dinP, mucB, umuC. Belongs to the DNA polymerase
type-Y family."
/db_xref="EnsemblGenomes-Gn:Rv3056"
/db_xref="EnsemblGenomes-Tr:CCP45865"
/db_xref="GOA:P9WNT1"
/db_xref="InterPro:IPR001126"
/db_xref="InterPro:IPR017961"
/db_xref="InterPro:IPR022880"
/db_xref="InterPro:IPR036775"
/db_xref="UniProtKB/Swiss-Prot:P9WNT1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45865.1"
/translation="MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTE
PRKVVTCASYEARAYGVRAGMPLRTAARRCPEATFLPSNPAAYNAASEEVVALLRDLG
YPVEVWGWDEAYLAVAPGTPDDPIEVAEEIRKVILSQTGLSCSIGISDNKQRAKIATG
LAKPAGIYQLTDANWMAIMGDRTVEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLM
STFGPRTALWLLLAKGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQR
TLNEVVASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFELDR
PVRLLGVRLELA"
gene complement(3417799..3418662)
/locus_tag="Rv3057c"
CDS complement(3417799..3418662)
/codon_start=1
/transl_table=11
/locus_tag="Rv3057c"
/product="Probable short chain alcohol
dehydrogenase/reductase"
/note="Rv3057c, (MTCY22D7.24), len: 287 aa. Probable
oxidoreductase, probably short-chain alcohol
dehydrogenase/reductase. Equivalent to Q9CBP7|ML1740
possible short chain dehydrogenases/reductase from
Mycobacterium leprae (312 aa), FASTA scores: opt:
1563,E(): 6e-89, (81.8% identity in 280 aa overlap). Also
similar to many oxidoreductases e.g. Q9ZBX8|SCD78.21c
putative oxidoreductase from Streptomyces coelicolor (585
aa), FASTA scores: opt: 541, E(): 6.7e-26, (37.25%
identity in 263 aa overlap); AAK47506|MT3170
oxidoreductase,short-chain dehydrogenase/reductase family
from Mycobacterium tuberculosis strain CDC1551 (276 aa),
FASTA scores: opt: 521, E(): 6.1e-25, (36.25% identity in
276 aa overlap); AAK45541|MT1283 oxidoreductase,
short-chain dehydrogenase/reductase family from
Mycobacterium tuberculosis strain CDC1551 (276 aa), FASTA
scores: opt: 471, E(): 7.2e-22, (32.4% identity in 281 aa
overlap). Also similar to O50460|Rv1245c|MTV006.17C
dehydrogenase (276 aa). Contains short-chain alcohol
dehydrogenase family signature (PS00061). May belong to
the short-chain dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv3057c"
/db_xref="EnsemblGenomes-Tr:CCP45866"
/db_xref="GOA:I6YB11"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6YB11"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45866.1"
/translation="MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDR
DRDGLAQTVCDARALGAQVPEHRVLDVSDYQDVAAFAADIHARHPSMDVVLNIAGVSA
WGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRGGHLVNVSSAAGLVGLPWH
AAYSASKYGLRGLSEVLRFDLARHGIGVSVVVPGAVKTPLVNTVEIAGVDRDDPRVNR
WVERFSGHAVTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVN
VFFTRALRPGP"
gene complement(3418726..3419376)
/locus_tag="Rv3058c"
CDS complement(3418726..3419376)
/codon_start=1
/transl_table=11
/locus_tag="Rv3058c"
/product="Possible transcriptional regulatory protein
(probably TetR-family)"
/note="Rv3058c, (MTCY22D7.23), len: 216 aa. Possible
transcriptional regulatory protein, TetR-family, showing
reasonable similarity to others e.g. AAK48337|MT3970 from
Mycobacterium tuberculosis strain CDC1551 (216 aa), FASTA
scores: opt: 261, E(): 2.8e-10, (31.7% identity in 221 aa
overlap); Q49962|ML1070|U1756B from Mycobacterium leprae
(217 aa), FASTA scores: opt: 234, E(): 1.8e-08, (27.2%
identity in 195 aa overlap); Q9CDD3|ML0064 from
Mycobacterium leprae (214 aa), FASTA scores: opt: 199,
E(): 3.6e-06, (25.65% identity in 195 aa overlap);
O66121|CPRS from Streptomyces coelicolor (215 aa), FASTA
scores: opt: 183, E(): 4.2e-05, (26.0% identity in 196 aa
overlap). Equivalent to AAK47476|MT3144 from Mycobacterium
tuberculosis strain CDC1551 (237 aa) but N-terminus
shorter 21 residues. Start was predicted by TBParse but
alternatives (ATG) are possible. Could belong to the
TetR/AcrR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3058c"
/db_xref="EnsemblGenomes-Tr:CCP45867"
/db_xref="GOA:P95100"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:P95100"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45867.1"
/translation="MTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSV
RAISLRAGVARSGFYFYFDSKYSVLAQILAEATEELEEASQHFSARQPGESPEQFVNR
MIGSVAAVYANNDPVLRACNAARQSDMEIRDILERQFQVLLRETIGVFEAEVKAGTAH
PISEDLPTLVRTLAATTALMLTGDALLVGPDSDAARRVRVLEQMWLNALWGGGKAP"
gene 3419492..3420970
/gene="cyp136"
/locus_tag="Rv3059"
CDS 3419492..3420970
/codon_start=1
/transl_table=11
/gene="cyp136"
/locus_tag="Rv3059"
/product="Probable cytochrome P450 136 Cyp136"
/note="Rv3059, (MTCY22D7.22c), len: 492 aa. Probable
cyp136, cytochrome P450 136, similar to other cytochrome
P450-dependent oxidases e.g. Q59990|CYP120|CYP|SLR0574
putative cytochrome P450 120 from Synechocystis sp. strain
PCC 6803 (444 aa), FASTA scores: opt: 579, E():
1.5e-29,(27.3% identity in 443 aa overlap);
Q64654|CYP51|CP51_RAT cytochrome P450 51 (lanosterol
14-alpha demethylase) from Rattus norvegicus (Rat) (503
aa), FASTA scores: opt: 549,E(): 1.4e-27, (26.2% identity
in 458 aa overlap); Q9JIY3|CYP51 lanosterol
14-alpha-demethylase from Mus musculus (Mouse) (486 aa),
FASTA scores: opt: 546, E(): 2.1e-27, (25.75% identity in
458 aa overlap). Contains cytochrome P450 cysteine
heme-iron ligand signature (PS00086). Belongs to the
cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv3059"
/db_xref="EnsemblGenomes-Tr:CCP45868"
/db_xref="GOA:P9WPM7"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002403"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPM7"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45868.1"
/translation="MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKK
LAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVA
ALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSR
LAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVT
KVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTV
LCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESD
RHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIA
YPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLEIK
TILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR"
gene complement(3421741..3423213)
/locus_tag="Rv3060c"
CDS complement(3421741..3423213)
/codon_start=1
/transl_table=11
/locus_tag="Rv3060c"
/product="Probable transcriptional regulatory protein
(probably GntR-family)"
/note="Rv3060c, (MTCY22D7.21), len: 490 aa. Probable
transcriptional regulatory protein, showing reasonable
similarity to several members of the GntR family e.g.
BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti)
(247 aa), FASTA scores: opt: 274, E(): 3.5e-10, (30.35%
identity in 224 aa overlap); P96570|ESMR from Burkholderia
cepacia (Pseudomonas cepacia) (277 aa), FASTA scores: opt:
229, E(): 2.8e-07, (25.85% identity in 240 aa overlap);
Q9S276|SCI28.07 from Streptomyces coelicolor (230
aa),FASTA scores: opt: 211, E(): 3.4e-06, (27.25% identity
in 220 aa overlap); etc. Seems to have two domains:
residues 1-260 resemble UxuR, and 260-490 resemble PdhR,
ExuR, etc. Contains bacterial regulatory proteins, GntR
family signature (PS00043). Helix-turn-helix motif (+3.13
SD) at aa 38-59. Seems to belong to the GntR family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3060c"
/db_xref="EnsemblGenomes-Tr:CCP45869"
/db_xref="GOA:P95098"
/db_xref="InterPro:IPR000524"
/db_xref="InterPro:IPR008920"
/db_xref="InterPro:IPR011711"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:P95098"
/inference="protein motif:PROSITE:PS00043"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45869.1"
/translation="MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASLGSESALQQ
RFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPATRAVVIYLEYLGTTIG
DLLGARLVLEPLAASLAAEHIDEPGIERLRAVLRAEERWRPGLPPPPEQFYRVLAEQS
KNPVLQLFIDILMRLTKRYVQKSGTQSAGEAVEAAGQVHNEHSDIVAAVTAGDSAWAK
TLSERHVEAVAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIG
DDIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPGGGLVVTT
PQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRRSEPEVASFLDTLGRP
RLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLFLLILVELFRRHLSSTEQALPTWS
DVVAVGHAHVRILEAIGSGDDSLARCRTRRHLDAAASWWL"
gene complement(3423262..3425427)
/gene="fadE22"
/locus_tag="Rv3061c"
CDS complement(3423262..3425427)
/codon_start=1
/transl_table=11
/gene="fadE22"
/locus_tag="Rv3061c"
/product="Probable acyl-CoA dehydrogenase FadE22"
/note="Rv3061c, (MTCY22D7.20), len: 721 aa. Probable
fadE22, Acyl-CoA Dehydrogenase, similar to many e.g.
AAK44503|MT0284 from Mycobacterium tuberculosis strain
CDC1551 (731 aa), FASTA scores: opt: 1804, E():
1.1e-101,(43.45% identity in 743 aa overlap);
AAK48037|MT3678 from Mycobacterium tuberculosis strain
CDC1551 (711 aa), FASTA scores: opt: 1630, E(): 3.9e-91,
(42.55% identity in 733 aa overlap); and extensive
similarity in C-terminal part to many acyl-CoA
dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter
crescentus (407 aa), FASTA scores: opt: 767,E(): 4.8e-39,
(36.7% identity in 376 aa overlap). Also similar to many
hypothetical proteins. Could belong to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3061c"
/db_xref="EnsemblGenomes-Tr:CCP45870"
/db_xref="GOA:I6X654"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:I6X654"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45870.1"
/translation="MGIALTDDHRELSGVARAFLTSQKVRWAARASLDAAGDARPPFW
QNLAELGWLGLHIDERHGGSGYGLSELVVVIEELGRAVAPGLFVPTVIASAVVAKEGT
DDQRARLLPALIDGTLTAGVGLDSQVQVTDGVADGEAGIVLGAGLAELLLVAAGDDVL
VLERGRKGVSVDVPENFDPTRRSGRVRLDNVRVTTDDILLGAYESALARARTLLAAEA
VGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHHCANMLVAAESAIAAVWDAARAAAE
DEEQFRLAAAVAAALAFPAYARNAELNIQVHGGIGFTWEHDAHLHLRRALVTVGLFGG
DAPVRDVFERTAAGVTRAISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGY
VMPHWPRPWGRAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFV
EKALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQYCARGLAT
VRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEVFFNDVFVPDEDVVGAP
NSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQLVQRRSDAFAGAPIRVGAFLAEDH
ALRLLNLRRAARSVEGAGPGPEGNITKLKVAEHMIEGAAIAAALWGPEIALLDGPGRV
IGRTVMGARGMAIAGGTSEVTRNQIAERILGMPRDPLIS"
gene 3425584..3427107
/gene="ligB"
/locus_tag="Rv3062"
CDS 3425584..3427107
/codon_start=1
/transl_table=11
/gene="ligB"
/locus_tag="Rv3062"
/product="Probable ATP-dependent DNA ligase LigB
(polydeoxyribonucleotide synthase [ATP]) (polynucleotide
ligase [ATP]) (sealase) (DNA repair protein) (DNA
joinase)"
/note="Rv3062, (MTCY22D7.19c), len: 507 aa. Probable
ligB,DNA ligase ATP-dependent (see citation below), highly
similar to numerous archaebacterial and eukaryotic
polynucleotide DNA ligases, e.g.
Q9FCB1|DNLI_STRCO|LIG|2SCG58.02 from Streptomyces
coelicolor (512 aa), FASTA scores: opt: 1677, E():
2.5e-90,(55.65% identity in 512 aa overlap);
Q9HR35|DNLI_HALN1|LIG|VNG0881G from Halobacterium sp.
strain NRC-1 (561 aa), FASTA scores: opt: 985, E():
5.6e-50, (42.25% identity in 440 aa overlap);
Q9V185|DNLI_PYRAB|LIG|PAB2002 from Pyrococcus abyssi (559
aa), FASTA scores: opt: 978, E(): 1.4e-49, (39.05%
identity in 443 aa overlap); etc. Also similar to
Rv3731|MTV025.079|LIGC possible DNA ligase from M.
tuberculosis (358 aa). Similarity at N-terminus is poor so
first start codon was taken. Contains (PS00697)
ATP-dependent DNA ligase AMP-binding site signature, and
(PS00017) ATP/GTP-binding site motif A (P-loop). Belongs
to the ATP-dependent DNA ligase family."
/db_xref="EnsemblGenomes-Gn:Rv3062"
/db_xref="EnsemblGenomes-Tr:CCP45871"
/db_xref="GOA:P9WNV5"
/db_xref="InterPro:IPR000977"
/db_xref="InterPro:IPR012308"
/db_xref="InterPro:IPR012309"
/db_xref="InterPro:IPR012310"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR016059"
/db_xref="InterPro:IPR022865"
/db_xref="InterPro:IPR036599"
/db_xref="UniProtKB/Swiss-Prot:P9WNV5"
/inference="protein motif:PROSITE:PS00697"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45871.1"
/translation="MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIV
SWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLPGKGSQAQRAAL
VAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQRAAMLGGDL
AAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQ
IHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVT
ASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDR
LITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAV
EWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFHEIAVGPTDG
YVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY"
gene 3427243..3429519
/gene="cstA"
/locus_tag="Rv3063"
CDS 3427243..3429519
/codon_start=1
/transl_table=11
/gene="cstA"
/locus_tag="Rv3063"
/product="Probable carbon starvation protein A homolog
CstA"
/note="Rv3063, (MTCY22D7.18c), len: 758 aa. Probable
cstA,integral membrane starvation-induced stress response
protein, similar to other e.g. P15078|CSTA_ECOLI|B0598
from Escherichia coli strain K12 (701 aa), FASTA scores:
opt: 2357, E(): 9.5e-137, (51.25% identity in 712 aa
overlap); AAG54933|CSTA from Escherichia coli strain
O157:H7 EDL933 (701 aa), FASTA scores: opt: 2356, E():
1.1e-136, (51.1% identity in 712 aa overlap); etc.
Predicted to be membrane associated. Similarity suggests
start at GTG at 16801 in Y22D7 but no RBS obvious so
TBParse-predicted start at 16881 taken. Belongs to the
CstA family."
/db_xref="EnsemblGenomes-Gn:Rv3063"
/db_xref="EnsemblGenomes-Tr:CCP45872"
/db_xref="GOA:P9WP47"
/db_xref="InterPro:IPR003706"
/db_xref="InterPro:IPR025299"
/db_xref="UniProtKB/Swiss-Prot:P9WP47"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45872.1"
/translation="MAAPTPSNRIEERSGHASCVRADADLPPVAILGRSPITLRHKIF
FVAVAVIGALAWTVVAFFRNEPVNAVWIVVAAGCTYIIGFRFYARLIEMKVVRPRDDH
ATPAEILDDGTDYVPTDRRVVFGHHFAAIAGAGPLVGPVLATQMGYLPSSIWIVVGAV
LAGCVQDYLVLWISVRRRGRSLGQMVRDELGATAGVAALVGIPVIITIVIAVLALVVV
RALAKSPWGVFSIAMTIPIAIFMGCYLRFLRPGRVSEVSLIGIGLLLLAVVSGDWVAH
TSWGAAWFSLSPVTLCWLLISYGFAASVLPVWLLLAPRDYLSTFMKVGTIALLAIGVC
AAHPIIEAPAVSKFAGSGNGPVFAGSLFPFLFITIACGALSGFHALICSGTTPKMLEK
EGQMRVIGYGGMMTESFVAVIALLTAAILDQHLYFTLNAPSLHTHDSAATAAKYVNGL
GLTGSPVTPDHISQAAASVGEQTIVSRTGGAPTLAFGMAEMLHRVVGGVGLKAFWYHF
AIMFEALFILTTVDAGTRAARFMISDALGNFGGVLRKLQNPSWRPGAWACRLVVVAAW
GSILLLGVTDPLGGINTLFPLFGIANQLLAGIALTVITVVVIKKGRLKWAWIPGIPLL
WDLAVTLTASWQKIFSADPSVGYWTQHAHYAAAQHAGETAFGSATNADEINDVVRNTF
VQGTLSIVFVVVVVLVVVAGVIVALKTIRGRGIPLAEDDPAPSTLFAPAGLIPTAAER
KLQRRLGAPASASVAAPD"
gene complement(3429825..3430250)
/locus_tag="Rv3064c"
CDS complement(3429825..3430250)
/codon_start=1
/transl_table=11
/locus_tag="Rv3064c"
/product="Probable conserved integral membrane protein"
/note="Rv3064c, (MTCY22D7.17), len: 141 aa. Probable
conserved integral membrane protein, similar to many e.g.
Q9KY40|SCC8A.08 putative integral membrane protein from
Streptomyces coelicolor (153 aa), FASTA scores: opt:
391,E(): 2.4e-18, (48.45% identity in 130 aa overlap);
Q9K461|SC2H12.23c putative integral membrane protein from
Streptomyces coelicolor (151 aa), FASTA scores: opt:
339,E(): 5.1e-15, (46.7% identity in 124 aa overlap);
BAB48975|MLR1652 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (130 aa), FASTA scores: opt: 319,
E(): 8.7e-14, (41.45% identity in 123 aa overlap);
Q9JR31|NMA2196|NMB0291 conserved hypothetical inner
membrane protein from Neisseria meningitidis serogroup a
and B (132 aa), FASTA scores: opt: 303, E():
9.4e-13,(43.65% identity in 126 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3064c"
/db_xref="EnsemblGenomes-Tr:CCP45873"
/db_xref="GOA:I6XG31"
/db_xref="InterPro:IPR032808"
/db_xref="UniProtKB/TrEMBL:I6XG31"
/protein_id="CCP45873.1"
/translation="MVKDLDRRLAGCLPAVLSLFRLVYGLLFAGYGSMILFGWPVTSA
QPVEFGSWPGWYAGVIELVAGLLIATGLFTRAVAFVASGEMAVAYFWMHQPYALWPIG
GPPDGNGGTPAILFCFGFFLLVFTGGGIYSIDARRTVTA"
gene 3430387..3430710
/gene="mmr"
/gene_synonym="emrE"
/locus_tag="Rv3065"
CDS 3430387..3430710
/codon_start=1
/transl_table=11
/gene="mmr"
/gene_synonym="emrE"
/locus_tag="Rv3065"
/product="Multidrugs-transport integral membrane protein
Mmr"
/note="Rv3065, (MT3150.1, MTCY22D7.17c), len: 107 aa.
Mmr,integral membrane multidrugs resistance transporter
(see citation below), equivalent to Q9CBP1|ML1756 probable
multidrug resistance protein from Mycobacterium leprae
(107 aa), FASTA scores: opt: 534, E(): 3.3e-28, (77.55%
identity in 107 aa overlap). Also highly similar to
bacterial proteins involved in resistance to ethidium
bromide or methyl viologen e.g. O87866|QACG_STASP
quaternary ammonium compound-resistance protein QACG
(quarternary ammonium determinant G) from Staphylococcus
sp. strain ST94 (107 aa), FASTA scores: opt: 307, E():
1.8e-13, (39.8% identity in 103 aa overlap); P96460|QAC
quaternary ammonium compounds resistance protein QAC from
Staphylococcus aureus (107 aa), FASTA scores: opt: 304,
E(): 2.8e-13, (40.4% identity in 104 aa overlap);
Q57225|QACE_ECOLI quaternary ammonium compound-resistance
protein QACE (quarternary ammonium determinant E) from
Escherichia coli (110 aa),FASTA scores: opt: 300, E():
5.2e-13, (48.15% identity in 108 aa overlap);
AAG55967|Z1870 methylviologen resistance protein encoded
within prophage CP-933X from Escherichia coli strain
O157:H7 EDL933 (110 aa); P23895|EMRE|MVRC|EB|B0543 EMRE
protein from Escherichia coli (110 aa), FASTA scores: opt:
290, E(): 2.3e-12,(43.55% identity in 101 aa overlap);
etc. Also similar to the SugE protein of enteric bacteria.
Belongs to the small multidrug resistance (SMR) protein
family. Note that previously known as emrE."
/db_xref="EnsemblGenomes-Gn:Rv3065"
/db_xref="EnsemblGenomes-Tr:CCP45874"
/db_xref="GOA:P9WGF1"
/db_xref="InterPro:IPR000390"
/db_xref="PDB:2IQ4"
/db_xref="UniProtKB/Swiss-Prot:P9WGF1"
/protein_id="CCP45874.1"
/translation="MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFA
LLALSISHGMQTDVAYALWSAIGTAAIVLVAVLFLGSPISVMKVVGVGLIVVGVVTLN
LAGAH"
gene 3430707..3431315
/locus_tag="Rv3066"
CDS 3430707..3431315
/codon_start=1
/transl_table=11
/locus_tag="Rv3066"
/product="Probable transcriptional regulatory protein
(probably DeoR-family)"
/note="Rv3066, (MTCY22D7.15c), len: 202 aa. Probable
transcriptional regulatory protein deoR-family, with some
similarity to transcriptional regulators and hypothetical
proteins, e.g. Q9X9V5|SCI7.35c hypothetical 21.1 KDA
protein from Streptomyces coelicolor (197 aa), FASTA
scores: opt: 398, E(): 5.7e-19, (40.3% identity in 191 aa
overlap); AAG55222|Z1073 putative DeoR-type
transcriptional regulator from Escherichia coli strain
O157:H7 EDL933 (178 aa), FASTA scores: opt: 257, E():
7.9e-10, (28.4% identity in 176 aa overlap); Q9HXU1|PA3699
probable transcriptional regulator (TetR/AcrR family) from
Pseudomonas aeruginosa (237 aa), FASTA scores: opt: 229,
E(): 6.7e-08, (32.1% identity in 187 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3066"
/db_xref="EnsemblGenomes-Tr:CCP45875"
/db_xref="GOA:I6X658"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="PDB:3T6N"
/db_xref="UniProtKB/TrEMBL:I6X658"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45875.1"
/translation="MTAGSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEA
NVPVGSTTYYFNDLDALREAALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYL
ADQDRYRTLNELYMAAAHRPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATL
HALITGTPLSTDELTDAIARLVADGPEQREVGQSAHAGRTPD"
gene 3431428..3431838
/locus_tag="Rv3067"
CDS 3431428..3431838
/codon_start=1
/transl_table=11
/locus_tag="Rv3067"
/product="Conserved hypothetical protein"
/note="Rv3067, (MTCY22D7.14c), len: 136 aa. Conserved
hypothetical protein, weakly similar to other
mycobacterium proteins e.g. O53953|Rv1804c|MTV049.26c (108
aa), FASTA scores: opt: 183, E(): 0.00053, (36.6% identity
in 82 aa overlap); O07222|Rv1810|MTCY16F9.04c (118 aa),
FASTA scores: opt: 149, E(): 0.05, (30.95% identity in 84
aa overlap). Has hydrophobic stretch at N-terminus. Start
chosen on basis of codon usage but upstream ATG also
possible."
/db_xref="EnsemblGenomes-Gn:Rv3067"
/db_xref="EnsemblGenomes-Tr:CCP45876"
/db_xref="GOA:I6YB21"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/Swiss-Prot:I6YB21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45876.1"
/translation="MLTVGVGIGAAILLGWFTLAHRHPDQPGAAATPPPAGLTTRSAP
TAAPPSTLQSPDLDSVFLGNLHDRGISFTNPDAAVYNGKMVCTNLGGGMTVQQVVEAL
QSSSPALGDRTTAYVAVSIRTYCPKYDAVLPPGS"
gene complement(3431840..3431912)
/gene="alaU"
tRNA complement(3431840..3431912)
/gene="alaU"
/product="tRNA-Ala"
/anticodon=(pos:complement(3431877..3431879),aa:Ala,
seq:ggc)
/note="codon recognized: GCC; alaU, tRNA-Ala, anticodon
ggc, length = 73"
gene complement(3431979..3433622)
/gene="pgmA"
/locus_tag="Rv3068c"
CDS complement(3431979..3433622)
/codon_start=1
/transl_table=11
/gene="pgmA"
/locus_tag="Rv3068c"
/product="Probable phosphoglucomutase PgmA (glucose
phosphomutase) (PGM)"
/note="Rv3068c, (MTCY22D7.13), len: 547 aa. Probable
pgmA,phosphoglucomutase, highly similar to other
phosphoglucomutases e.g. Q9L117|PGM from Streptomyces
coelicolor (546 aa), FASTA scores: opt: 2569, E():
2.8e-149, (71.4% identity in 545 aa overlap);
Q9ABY5|CC0085 from Caulobacter crescentus (545 aa), FASTA
scores: opt: 2465, E(): 6.2e-143, (70.4% identity in 541
aa overlap); P38569|PGMU_ACEXY|CELB from Acetobacter
xylinum (555 aa),FASTA scores: opt: 2206, E(): 4e-127,
(62.25% identity in 543 aa overlap); P74643|PGM|SLL0726
from Synechocystis sp. strain PCC 6803 (567 aa), FASTA
scores: opt: 2168, E(): 8.5e-125, (60.0% identity in 550
aa overlap); P36938|PGMU_ECOLI|PGM|B0688 from Escherichia
coli (546 aa),FASTA scores: opt: 2111, E(): 2.5e-121,
(58.2% identity in 550 aa overlap). Also similar to other
phosphomannomutases. Has phosphoglucomutase and
phosphomannomutase signature (PS00710) and ATP/GTP-binding
site motif A (P-loop) (PS00017). Belongs to the
phosphohexose mutases family."
/db_xref="EnsemblGenomes-Gn:Rv3068c"
/db_xref="EnsemblGenomes-Tr:CCP45877"
/db_xref="GOA:I6Y2G3"
/db_xref="InterPro:IPR005843"
/db_xref="InterPro:IPR005844"
/db_xref="InterPro:IPR005845"
/db_xref="InterPro:IPR005846"
/db_xref="InterPro:IPR005852"
/db_xref="InterPro:IPR016055"
/db_xref="InterPro:IPR016066"
/db_xref="InterPro:IPR036900"
/db_xref="UniProtKB/TrEMBL:I6Y2G3"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00710"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45877.1"
/translation="MVANPRAGQPAQPEDLVDLPHLVTAYYSIEPDPDDLAQQVAFGT
SGHRGSALTGTFNELHILAITQAIVEYRAAQGTTGPLFIGRDTHGLSEPAWVSALEVL
AANQVVAVVDSRDRYTPTPAISHAILTYNRGRTEALADGIVVTPSHNPPSDGGIKYNP
PNGGPADTAATTAIAKRANEILLARSMVKRLPLARALRTAQRHDYLGHYVDDLPNVVD
IAAIREAGVRIGADPLGGASVDYWGEIAHRHGLDLTVVNPLVDATWRFMTLDTDGKIR
MDCSSPDAMAGLIRTMFGNRERYQIATGNDADADRHGIVTPDEGLLNPNHYLAVAIEY
LYTHRPSWPAGIAVGKTVVSSSIIDRVVAGIGRQLVEVPVGFKWFVDGLIGATLGFGG
EESAGASFLRRDGSVWTTDKDGIIMALLAAEILAVTGATPSQRYHALAGEYGGPCYAR
IDAPADREQKARLARLSADQVSATELAGEPITAKLTTAPGNGAALGGLKVTTANAWFA
ARPSGTEDVYKIYAESFRGPQHLVEVQQTAREVVDRVIG"
gene 3433692..3434090
/locus_tag="Rv3069"
CDS 3433692..3434090
/codon_start=1
/transl_table=11
/locus_tag="Rv3069"
/product="Probable conserved transmembrane protein"
/note="Rv3069, (MTCY22D7.12c), len: 132 aa. Probable
conserved transmembrane protein, similar to several
hypothetical and CRCB bacterial proteins e.g.
Q9A6V2|CC1981 CRCB protein (see citation below; seems to
be involved in camphor resistance and chromosome
condensation, promoting or protecting chromosome folding)
from Caulobacter crescentus (127 aa), FASTA scores: opt:
275, E(): 1.6e-11,(41.1% identity in 124 aa overlap);
Q9FC39|SC4G1.10 putative integral membrane protein from
Streptomyces coelicolor (154 aa), FASTA scores: opt: 258,
E(): 2.5e-10,(42.15% identity in 121 aa overlap);
Q9V0X2|PAB1925 CRCB protein (see citation below) from
Pyrococcus abyssi (123 aa), FASTA scores: opt: 256, E():
2.8e-10, (39.8% identity in 113 aa overlap); O59171|PH1502
hypothetical 13.6 KDA protein from Pyrococcus horikoshii
(123 aa), FASTA scores: opt: 249, E(): 8.2e-10, (38.65%
identity in 119 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3069"
/db_xref="EnsemblGenomes-Tr:CCP45878"
/db_xref="GOA:P9WP63"
/db_xref="InterPro:IPR003691"
/db_xref="UniProtKB/Swiss-Prot:P9WP63"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45878.1"
/translation="MPNHDYRELAAVFAGGALGALARAALSALAIPDPARWPWPTFTV
NVVGAFLVGYFTTRLLERLPLSSYRRPLLGTGLCGGLTTFSTMQVETISMIEHGHWGL
AAAYSVVSITLGLLAVHLATVLVRRVRIRR"
gene 3434087..3434467
/locus_tag="Rv3070"
CDS 3434087..3434467
/codon_start=1
/transl_table=11
/locus_tag="Rv3070"
/product="Probable conserved integral membrane protein"
/note="Rv3070, (MTCY22D7.11c), len: 126 aa. Probable
conserved integral membrane protein, similar to several
hypothetical and CRCB bacterial proteins e.g.
Q9FC37|SC4G1.12 putative integral membrane protein from
Streptomyces coelicolor (124 aa), FASTA scores: opt:
280,E(): 3.1e-11, (45.3% identity in 117 aa overlap);
O25823|HP1225 conserved hypothetical integral membrane
protein from Helicobacter pylori (Campylobacter pylori)
(130 aa), FASTA scores: opt: 225, E(): 1e-07, (33.35%
identity in 123 aa overlap); O07590|YHDU hypothetical 12.4
KDA protein from Bacillus subtilis (118 aa), FASTA scores:
opt: 224, E(): 1.1e-07, (37.85% identity in 111 aa
overlap); Q9KVS9|VC0060 CRCB protein (see Hu et al., 1996;
seems involved in camphor resistance and chromosome
condensation, promoting or protecting chromosome folding)
from Vibrio cholera (126 aa), FASTA scores: opt: 221, E():
1.8e-07, (33.35% identity in 126 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3070"
/db_xref="EnsemblGenomes-Tr:CCP45879"
/db_xref="GOA:P9WP61"
/db_xref="InterPro:IPR003691"
/db_xref="UniProtKB/Swiss-Prot:P9WP61"
/protein_id="CCP45879.1"
/translation="MTASTALTVAIWIGVMLIGGIGSVLRFLVDRSVARRLARTFPYG
TLTVNITGAALLGFLAGLALPKDAALLAGTGFVGAYTTFSTWMLETQRLGEDRQMVSA
LANIVVSVVLGLAAALLGQWIAQI"
gene 3434464..3435573
/locus_tag="Rv3071"
CDS 3434464..3435573
/codon_start=1
/transl_table=11
/locus_tag="Rv3071"
/product="Conserved hypothetical protein"
/note="Rv3071, (MTCY22D7.10c), len: 369 aa. Conserved
hypothetical protein, weakly similar in N-terminus of
Q9A4V0|CC2725 hypothetical protein CC2725 from Caulobacter
crescentus (113 aa), FASTA scores: opt: 141, E():
0.031,(27.6% identity in 105 aa overlap). C-terminal
region also weakly similar to other hypothetical proteins
e.g. Q9FC38|YG11_STRCO from Streptomyces coelicolor (114
aa),FASTA scores: opt: 151, E(): 0.007, (31.65% identity
in 98 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3071"
/db_xref="EnsemblGenomes-Tr:CCP45880"
/db_xref="GOA:P95087"
/db_xref="InterPro:IPR003793"
/db_xref="InterPro:IPR011322"
/db_xref="InterPro:IPR015867"
/db_xref="UniProtKB/TrEMBL:P95087"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45880.1"
/translation="MNEQCLKLTAYFGERQRAVGGAGRFLADAMLDLFGSHNVATSVM
LRGTTSFGPKHEFRCDQSLSLSEDPPVTVAAVDIESKIRSLVDDVTAMTDRGLVTLER
ARLVTRHSGAEEFGDIDSRNGDAAKLTIYAGRQVRVAGAPAYYTICELLHRHGFAGAT
VLLGVDGTAHGRRRRARFFGRNVNVPLMIIAVGTPAQVAVAAMELTAALPNPLLTIER
VRLCKRDGELFARPQQLPQTDDQGRTLWQKLMVHTAEATHHEGLPIHRALVHRLMQSE
TARGATALRGIWGFYGDHKPHGDKLFQLVRRVPVTTIIVDTPQAIARSFDIVDELTNW
HGLVTSEMVPAAVSLTGSRDGTQKTGETPLARYDY"
gene complement(3435798..3436322)
/locus_tag="Rv3072c"
CDS complement(3435798..3436322)
/codon_start=1
/transl_table=11
/locus_tag="Rv3072c"
/product="Conserved hypothetical protein"
/note="Rv3072c, (MTCY22D7.09), len: 174 aa. Hypothetical
protein, similar in part to O87779 hypothetical 18.1 KDA
protein (fragment) from Mycobacterium paratuberculosis
(166 aa), FASTA scores: opt: 238, E(): 2.5e-08, (42.6%
identity in 108 aa overlap); Q9AH10 putative
F420-dependent dehydrogenase from Rhodococcus erythropolis
(295 aa), FASTA scores: opt: 228, E(): 1.7e-07, (34.25%
identity in 111 aa overlap);
P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 possible
oxidoreductase from Mycobacterium tuberculosis strain
H37Rv (304 aa), FASTA scores: opt: 208, E(): 3.2e-06,
(38.9% identity in 108 aa overlap); etc. N-terminal region
similar to several proteins from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv3072c"
/db_xref="EnsemblGenomes-Tr:CCP45881"
/db_xref="GOA:P95086"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:P95086"
/protein_id="CCP45881.1"
/translation="MACVRRSCDVTGTARAGIGAGADPAVVDAVAVAADDCGFATLWV
GEHVVMVDRPASRYPYSRDGVIAVPAQADWLDPMIALSFAAAASSRVDVATGVLLLPE
HNPVIVAKEAASLDRLSGRRLTLGVASDGPRRSSTRSECHSSGAQSAPPNTSLQCAHY
GATTSHRSTATVGS"
gene complement(3436329..3436685)
/locus_tag="Rv3073c"
CDS complement(3436329..3436685)
/codon_start=1
/transl_table=11
/locus_tag="Rv3073c"
/product="Conserved hypothetical protein"
/note="Rv3073c, (MTCY22D7.08), len: 118 aa. Conserved
hypothetical protein, highly similar to other e.g.
Q9F3D7|SC2H2.18 from Streptomyces coelicolor (119
aa),FASTA scores: opt: 399, E(): 2.5e-20, (53.05% identity
in 115 aa overlap); Q9K4K9|SC5F8.15c from Streptomyces
coelicolor (117 aa), FASTA scores: opt: 334, E():
6e-16,(49.1% identity in 112 aa overlap); Q9HKD5|TA0666
from Thermoplasma acidophilum (134 aa), FASTA scores: opt:
334,E(): 6.7e-16, (42.35% identity in 111 aa overlap);
BAB53507|MLL7394 from Rhizobium loti (Mesorhizobium loti)
(120 aa), FASTA scores: opt: 309, E(): 3e-14, (43.65%
identity in 110 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3073c"
/db_xref="EnsemblGenomes-Tr:CCP45882"
/db_xref="InterPro:IPR007438"
/db_xref="UniProtKB/Swiss-Prot:P9WL11"
/protein_id="CCP45882.1"
/translation="MVRETRVRVARVYEDIDPDDGQRVLVDRIWPHGIRKDDQRVGIW
CKDVAPSKELREWYHHQPERFDEFASRYQEELHDSAALAELRKLTGRSVVTPVTATRH
VARSHAAVLAQLLNGR"
gene 3436779..3438053
/locus_tag="Rv3074"
CDS 3436779..3438053
/codon_start=1
/transl_table=11
/locus_tag="Rv3074"
/product="Conserved hypothetical protein"
/note="Rv3074, (MTCY22D7.07c), len: 424 aa. Conserved
hypothetical protein, highly similar but shorter (46 aa)
to P71806|Rv1378c|MTCY02B12.12c hypothetical 51.3 KDA
protein from Mycobacterium tuberculosis (475 aa), FASTA
scores: opt: 2009, E(): 5.8e-113, (72.95% identity in 429
aa overlap); and also similar to other hypothetical
mycobacterium proteins e.g. O33266|Rv0336|MTCY279.03 (503
aa), FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity
in 381 aa overlap); O33360|Rv0515|MTCY20G10.05 (503
aa),FASTA scores: opt: 337, E(): 7.5e-13, (28.6% identity
in 381 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3074"
/db_xref="EnsemblGenomes-Tr:CCP45883"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:I6XG38"
/protein_id="CCP45883.1"
/translation="MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAAAVDA
ARRAAEGAAGVPAARRGRGLASEIALARRDSPARGSRHLGFAKALVYEMPHTLAALDC
GALSEWRATLIVRESACLDVADRRALDAELCGDPGDLEGMGDARVVAAARAIAYRLDP
QAVVDRAANAENDRTVTIRPAPDTMTYLTALLPVAQGVSVYAALTRAADTRCDGRSRG
QVMADTLVERVTGRDAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMV
ASAVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRTPYCDAP
IRHRDHAHPWADGGPTSAHNGLGTCERCNYAKQAPGWRVSTSVDENHTHTAEFITPTG
SRHRSGAPPHLPAVTVSELEVRIGIALARYAA"
gene complement(3438050..3438973)
/locus_tag="Rv3075c"
CDS complement(3438050..3438973)
/codon_start=1
/transl_table=11
/locus_tag="Rv3075c"
/product="Conserved protein"
/note="Rv3075c, (MTCY22D7.06), len: 307 aa. Conserved
protein, with some similarity to Q9I562|PA0883 probable
acyl-CoA lyase beta chain from Pseudomonas aeruginosa (275
aa), FASTA scores: opt: 408, E(): 9.2e-19, (35.15%
identity in 273 aa overlap); Q9S2U9|SC4G6.02 putative
citrate lyase beta chain from Streptomyces coelicolor (274
aa), FASTA scores: opt: 384, E(): 3.1e-17, (34.7% identity
in 265 aa overlap); O06162|cite|Rv2498c|MTCY07A7.04c from
Mycobacterium tuberculosis (273 aa), FASTA scores: opt:
349, E(): 5.1e-15, (35.2% identity in 264 aa overlap);
etc. Several initiation codons possible, first one
chosen."
/db_xref="EnsemblGenomes-Gn:Rv3075c"
/db_xref="EnsemblGenomes-Tr:CCP45884"
/db_xref="GOA:I6YF40"
/db_xref="InterPro:IPR005000"
/db_xref="InterPro:IPR011206"
/db_xref="InterPro:IPR015813"
/db_xref="InterPro:IPR040442"
/db_xref="UniProtKB/TrEMBL:I6YF40"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45884.1"
/translation="MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAA
HSRADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWADDLAMLAD
SPVGGVMLAMVESVDHVTETAKRLPNVPIVALVETARGLERINEIAAAKGTFRLAFGI
GDFRRDTGFGEDPATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVSAEF
GMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLPRIARATK
ILDLARAYGIEVSDFEDEPVHMPAPTDTYHY"
gene 3439072..3439548
/locus_tag="Rv3076"
CDS 3439072..3439548
/codon_start=1
/transl_table=11
/locus_tag="Rv3076"
/product="Conserved hypothetical protein"
/note="Rv3076, (MTCY22D7.05c), len: 158 aa. Conserved
hypothetical protein, weakly similar to Q9AK12|SC8D11.07
hypothetical 17.0 KDA protein from Streptomyces coelicolor
(151 aa), FASTA scores: opt: 110, E(): 1.5, (25.5%
identity in 145 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3076"
/db_xref="EnsemblGenomes-Tr:CCP45885"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:I6X666"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45885.1"
/translation="MVLDGVVSDTRRSRTIAARQQTIWDVLADFGSLSSWVEGVDHSC
VLNHGPDGGALGSTRRVQVGRNTLVERVIEFDPPTTLAYRIEGLPARLRKVTNRWTLR
PADPVGAVTVVTLTSTIEIGGNPLARLAELVVGRAMAKRSNTMLAGLAQRLEDKHG"
gene 3439541..3441352
/gene_synonym="atsF"
/locus_tag="Rv3077"
CDS 3439541..3441352
/codon_start=1
/transl_table=11
/gene_synonym="atsF"
/locus_tag="Rv3077"
/product="Possible hydrolase"
/note="Rv3077, (MTCY22D7.04c), len: 603 aa. Possible
hydrolase, with some similarity to variety of hydrolases
(aryl- and steryl sulfatases principaly) e.g. Q45087|PEHA
phosphonate monoester hydrolase from Burkholderia
caryophylli (514 aa), FASTA scores: opt: 239, E():
7.2e-07,(23.95% identity in 413 aa overlap); Q9I1E5|PA2333
probable sulfatase from Pseudomonas aeruginosa (538 aa),
FASTA scores: opt: 231, E(): 2.3e-06, (28.1% identity in
516 aa overlap); P31447|YIDJ_ECOLI|B3678 putative
sulfatase from Escherichia coli (497 aa), FASTA scores:
opt: 222, E(): 7.4e-06, (27.7% identity in 390 aa
overlap); etc. Note that previously known as atsF."
/db_xref="EnsemblGenomes-Gn:Rv3077"
/db_xref="EnsemblGenomes-Tr:CCP45886"
/db_xref="GOA:Q6MX15"
/db_xref="InterPro:IPR000917"
/db_xref="InterPro:IPR017850"
/db_xref="UniProtKB/TrEMBL:Q6MX15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45886.1"
/translation="MANRPDIIIVMTDEERAVPPYESAEVLAWRQRSLTGRRWFDEHG
ISFTRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKRFDDSRLRWLRAGEVPTLG
NWFRAAGYDTHYDGKWHISHADLEDPATGAPLATNDNEGVVDSAAVRRYLDADPLGPY
GFSGWVGPEPHGAGLANSGFRRDPLVADRVVAWLTERYARRRAGDTAAMRPFLLVASF
VNPHDIVLFPAWVWRSPLKPSPLDPPHVPAAPTADEDLSTKPAAQVAYREAYYSGYGL
TRMVSRNYARNAQRYRDLYYRLHAEVDGPIDRVGRAVTEGGSEDAMLVRTSDHGDLLG
AHGGLHQKWFNLYDEATRVPFVIARIGEKATQPRTVSAPTSHVDLVPTLLSAAGVDVD
VVAAALAESFSEVHPLPGRDLMPVVDGASADEGRAIYLMTRDNVLEGDTGASLLSRQL
GRIVNPPAPLRIKVPAHVAANFEGLVVRVDDTDAAGGAGHLWKLVRTFDDPATWTEPG
VRHLATNGMGGDAYRTDPLDDQWELYDLTADPIEAYNRWTDPQLHELRQHLRMLLKQQ
RAVSVPERNQPWPYAHRLPPSGASNGLVRRVLGRFVR"
gene 3441353..3441754
/gene="hab"
/locus_tag="Rv3078"
CDS 3441353..3441754
/codon_start=1
/transl_table=11
/gene="hab"
/locus_tag="Rv3078"
/product="Probable hydroxylaminobenzene mutase Hab"
/note="Rv3078, (MTCY22D7.03c), len: 133 aa. Probable
hab,hydroxylaminobenzene mutase (5.-.-.-) (see Davis et
al.,2000), highly similar to two hydroxylaminobenzene
mutases from Pseudomonas pseudoalcaligenes O52214|HABA
(135 aa),FASTA scores: opt: 495, E(): 6.8e-25, (51.1%
identity in 133 aa overlap); and O52216|HABB (164 aa),
FASTA scores: opt: 479, E(): 8.2e-24, (51.9% identity in
133 aa overlap) (see Davis et al., 2000); and to
Q9AH35|NBZB hydroxylaminobenzene mutase from Pseudomonas
putida (164 aa), FASTA scores: opt: 476, E(): 1.3e-23,
(51.8% identity in 133 aa overlap) (see Park & Kim 2000).
Gene name according to Pseudomonas pseudoalcaligenes
nomenclature. Also similarity with putative different
membrane proteins involved in transport (protein predicted
to be a transmembrane protein)."
/db_xref="EnsemblGenomes-Gn:Rv3078"
/db_xref="EnsemblGenomes-Tr:CCP45887"
/db_xref="GOA:I6Y2H3"
/db_xref="UniProtKB/TrEMBL:I6Y2H3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45887.1"
/translation="MQKLLFTIGLALFLIGLLTGLVIPALKNPRMALSSHLEGVLNGM
FLVVLGLLWPHIDLPEAWQVIAVALIVYSAYANWLATLLAAAWGAGRKFAPIATGDHK
APAAKEGFVSFLLLSLSVAIVIGVVIVIIGL"
gene complement(3441770..3442597)
/locus_tag="Rv3079c"
CDS complement(3441770..3442597)
/codon_start=1
/transl_table=11
/locus_tag="Rv3079c"
/product="Conserved protein"
/note="Rv3079c, (MTCY22D7.02), len: 275 aa. Conserved
protein, similar to other hypothetical mycobacterium
proteins e.g. P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21
possible oxidoreductase from Mycobacterium tuberculosis
strain H37Rv (282 aa), FASTA scores: opt: 668, E():
2.4e-34, (40.55% identity in 281 aa overlap);
O06216|Rv2161c|MTCY270.07 from Mycobacterium tuberculosis
strain H37Rv (288 aa), FASTA scores: opt: 595, E():
8.5e-30, (40.9% identity in 274 aa overlap); O87779 from
Mycobacterium paratuberculosis (166 aa), FASTA scores:
opt: 464, E(): 7.2e-22, (41.55% identity in 166 aa
overlap); etc. Also some similarity to other proteins e.g.
Q9AH10 putative F420-dependent dehydrogenase from
Rhodococcus erythropolis (295 aa), FASTA scores: opt: 401,
E(): 9.6e-18, (30.2% identity in 288 aa overlap);
Q9AE04|RIF17 RIF17 protein from Amycolatopsis mediterranei
(356 aa),FASTA scores: opt: 298, E(): 2.8e-11, (35.0%
identity in 203 aa overlap); AAK48081|MT3720
luciferase-related protein from Mycobacterium tuberculosis
strain CDC1551 (395 aa),FASTA scores: opt: 223, E():
1.4e-06, (29.4% identity in 211 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3079c"
/db_xref="EnsemblGenomes-Tr:CCP45888"
/db_xref="GOA:I6XG43"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019921"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:I6XG43"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45888.1"
/translation="MQFGVLTFVTDEGIGPAELGAALEHRGFESLFLAEHTHIPVNTQ
SPYPGGGPIPEKYYRTLDPFVALAAAAATTQSLVLGTGIALIPERDPIVTAKEVASLD
LVSQGRFRFGVGVGWLREEVANHGVDPAVRGRVIDERLRAIIEIWTQEQAEFHGTYVD
FDPIYCWPKPVTKPYPPLYVGGGPANFPRIARLNAGWIAISPSPQRLSGPLQRLRAMA
GGDVPVTVCQWGEAAAKDLEGYRHLGVERVLLELPTEPRDPTLRYLDKLQAELARLA"
gene complement(3442656..3445988)
/gene="pknK"
/locus_tag="Rv3080c"
CDS complement(3442656..3445988)
/codon_start=1
/transl_table=11
/gene="pknK"
/locus_tag="Rv3080c"
/product="Serine/threonine-protein kinase transcriptional
regulatory protein PknK (protein kinase K) (STPK K)"
/note="Rv3080c, (MTV013.01c-MTCY22D7.01), len: 1110 aa.
pknK, serine/threonine protein kinase involved in
transcriptional regulatory function (see citation below).
Similar but shorter in N-terminus (approximately 300
residues) to others e.g. Q48411|ACOK transcriptional
regulatory protein of aco ABCD operon from Klebsiella
pneumoniae (921 aa), FASTA scores: opt: 886, E():
7.6e-37,(27.75% identity in 829 aa overlap); Q9HX92|PA3921
probable transcriptional regulator from Pseudomonas
aeruginosa (belongs to the LuxR/UhpA family of
transcriptional regulators) (906 aa), FASTA scores: opt:
760, E(): 1.5e-30,(29.55% identity in 822 aa overlap);
Q9I2X9|PA1760 probable transcriptional regulator from
Pseudomonas aeruginosa (belongs to the LuxR/UhpA family of
transcriptional regulators) (907 aa), FASTA scores: opt:
696, E(): 2.3e-27,(25.85% identity in 685 aa overlap);
P06993|malt (alias BAB37683|ECS4260 and AAG58520|malt)
positive regulator of MAL regulon from Escherichia coli
strain O157:H7 (901 aa),FASTA scores: opt: 660, E():
1.4e-25, (29.25% identity in 530 aa overlap);
Q9KNF3|VCA0011 malt regulatory protein from Vibrio
cholerae (belongs to the LuxR/UhpA family of
transcriptional regulators) (921 aa), FASTA scores: opt:
626, E(): 7.2e-24, (25.8% identity in 659 aa overlap);
etc. N-terminal region similar to N-terminus of
serine/threonine kinases e.g. Q9KK90|PKMA serine/threonine
kinase (similar to the Ser/Thr family of protein kinases)
from Amycolatopsis mediterranei (589 aa), FASTA scores:
opt: 545, E(): 5.7e-20, (34.45% identity in 334 aa
overlap); Q9RPT5|AMK serine/threonine protein kinase
homolog (similar to the Ser/Thr family of protein kinases)
from Amycolatopsis mediterranei (606 aa), FASTA scores:
opt: 537, E(): 1.5e-19, (35.55% identity in 346 aa
overlap); Q9L0I0|PKAD protein serine/threonine kinase from
Streptomyces coelicolor (599 aa), FASTA scores: opt:
520,E(): 1e-18, (36.1% identity in 324 aa overlap); etc.
N-terminal part also similar to
O53510|PKNL_MYCTU|Rv2176|MT2232|MTV021.09 probable
serine/threonine-protein kinase from Mycobacterium
tuberculosis strain H37Rv (399 aa), FASTA scores: opt:
511,E(): 2.1e-18, (35.15% identity in 313 aa overlap).
Contains PS00107 Protein kinases ATP-binding region
signature and PS00017 ATP/GTP-binding site motif A
(P-loop). Contains Hank's kinase subdomain. First part of
the protein seems belong to the Ser/Thr family of protein
kinases, and second parts seems belongs to the LuxR/UhpA
family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3080c"
/db_xref="EnsemblGenomes-Tr:CCP45889"
/db_xref="GOA:P9WI65"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016236"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041664"
/db_xref="UniProtKB/Swiss-Prot:P9WI65"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00107"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45889.1"
/translation="MTDVDPHATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCV
QPSLDRAVAVKVLSTDLDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLAGGRPFIV
MPYHAKNSLETLIRRHGPLDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDY
GEPQLTDFGIARIAGGFETATGVIAGSPAFTAPEVLEGASPTPASDVYSLGATLFCAL
TGHAAYERRSGERVIAQFLRITSQPIPDLRKQGLPADVAAAIERAMARHPADRPATAA
DVGEELRDVQRRNGVSVDEMPLPVELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPAT
KYRPSVPTGSLVTRSRLTDILRAGGRRRLILIHAPSGFGKSTLAAQWREELSRDGAAV
AWLTIDNDDNNEVWFLSHLLESIRRVRPTLAESLGHVLEEHGDDAGRYVLTSLIDEIH
ENDDRIAVVIDDWHRVSDSRTQAALGFLLDNGCHHLQLIVTSWSRAGLPVGRLRIGDE
LAEIDSAALRFDTDEAAALLNDAGGLRLPRADVQALTTSTDGWAAALRLAALSLRGGG
DATQLLRGLSGASDVIHEFLSENVLDTLEPELREFLLVASVTERTCGGLASALAGITN
GRAMLEEAEHRGLFLQRTEDDPNWFRFHQMFADFLHRRLERGGSHRVAELHRRASAWF
AENGYLHEAVDHALAAGDPARAVDLVEQDETNLPEQSKMTTLLAIVQKLPTSMVVSRA
RLQLAIAWANILLQRPAPATGALNRFETALGRAELPEATQADLRAEADVLRAVAEVFA
DRVERVDDLLAEAMSRPDTLPPRVPGTAGNTAALAAICRFEFAEVYPLLDWAAPYQEM
MGPFGTVYAQCLRGMAARNRLDIVAALQNFRTAFEVGTAVGAHSHAARLAGSLLAELL
YETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDHEGAADRLSTGGD
TAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTIPRDNGIATMTAELDEDSAV
RLLSAGDSADRDQACQRAGALAAAIDGTRRPLAALQAQILHIETLAATGRESDARNEL
APVATKCAELGLSRLLVDAGLA"
gene 3446040..3447278
/locus_tag="Rv3081"
CDS 3446040..3447278
/codon_start=1
/transl_table=11
/locus_tag="Rv3081"
/product="Conserved hypothetical protein"
/note="Rv3081, (MTV013.02), len: 412 aa. Conserved
hypothetical protein. Second part of the protein
(approximately residues 250-412) shares weak similarity
with other hypothetical proteins e.g. Q9YEU3|APE0488 from
Aeropyrum pernix (188 aa), FASTA scores: opt: 149, E():
0.019, E(): 0.019, (29.5% identity in 173 aa overlap); and
first part shares weak similarity with C-terminal part of
Q9RVT9|DR0933 alpha-amlyase from Deinococcus radiodurans
(644 aa), FASTA scores: opt: 127, E(): 1.4, (27.25%
identity in 198 aa overlap). Equivalent to AAK47502|MT3166
hypothetical 48.3 KDA protein from Mycobacterium
tuberculosis strain CDC1551 (436 aa) but shorter 24 aa in
N-terminus. Contains PS00850 Glycine radical signature and
possible helix-turn-helix motif at aa 53-74."
/db_xref="EnsemblGenomes-Gn:Rv3081"
/db_xref="EnsemblGenomes-Tr:CCP45890"
/db_xref="GOA:O53298"
/db_xref="InterPro:IPR018700"
/db_xref="UniProtKB/TrEMBL:O53298"
/inference="protein motif:PROSITE:PS00850"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45890.1"
/translation="MTPHYRQAAASRLDTHRTQKLRSQTNGGKDRHQLTYEQFARMLT
LMGPSDLWTVERAARHWGVSASRARAILSSRHIHRVSGYPAQAIKAVTLRQGARTDLK
TANHLVPAAQAFTMAETGAAIGETEDERARLRIFFEFLRGADETGTSALDLIVDEPAL
IGEHRFDALLAAAAEYISARWGRPGPLWSVSIERFLDTAWWVSDLPSARAFAAVWTPA
PFRRRGIYLDRHDLTSDGVCVMPEPVFNRTELQRAFTALAAKLERRGVVGQVHVVGGA
AMLLAYNSRVTTRDIDALFSTDGPMLEAIREVADEMGWPRTWLNNQASGYVSRTPGEG
APVFDHPFLHVVATPAQHLLAMKVVAARGVRDGEDIRLLLDRLRITSAAGVWEIVARY
FPAETITDRSRLLVEDLLNQ"
gene complement(3447404..3448426)
/gene="virS"
/locus_tag="Rv3082c"
CDS complement(3447404..3448426)
/codon_start=1
/transl_table=11
/gene="virS"
/locus_tag="Rv3082c"
/product="Virulence-regulating transcriptional regulator
VirS (AraC/XylS family)"
/note="Rv3082c, (MT3167, MTV013.03c), len: 340 aa.
VirS,transcriptional regulatory protein araC/xylS
family,probably involved in virulence (see citations
below). Similar to many transcriptional regulators
araC/xylS family e.g. Q9HZ25|PA3215 probable
transcriptional regulator (AraC/XylS family) from
Pseudomonas aeruginosa (337 aa),FASTA scores: opt: 379,
E(): 3e-17, (30.4% identity in 306 aa overlap);
Q9Z3Y6|PHBR polyhydroxybutyrate transcriptional activator
from Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt:
336, E(): 2e-14, (26.35% identity in 334 aa overlap);
P72171|ORUR|PA0831 ornithine utilization transcriptional
regulator oruR from Pseudomonas aeruginosa (339 aa), FASTA
scores: opt: 274, E(): 1.9e-10,(23.7% identity in 321 aa
overlap); Q9ZFW7 virulence regulating homolog from
Pseudomonas alcaligenes (346 aa),FASTA scores: opt: 262,
E(): 1.2e-09, (24.5% identity in 339 aa overlap); etc.
Also similar to O69703|Rv3736|MTV025.084 putative
regulatory protein (AraC/XylS family) from Mycobacterium
tuberculosis strain H37Rv (353 aa), FASTA scores: opt:
656, E(): 3.5e-35,(36.95% identity in 333 aa overlap). Has
potential helix-turn-helix motif at positions 252-273.
Belongs to the AraC/XylS family of transcriptional
regulators. Substrate of PknK."
/db_xref="EnsemblGenomes-Gn:Rv3082c"
/db_xref="EnsemblGenomes-Tr:CCP45891"
/db_xref="GOA:P9WMJ3"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR018060"
/db_xref="InterPro:IPR032687"
/db_xref="UniProtKB/Swiss-Prot:P9WMJ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45891.1"
/translation="MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQED
AFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIG
RYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGP
QARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRI
ATKYLESQYLPSDATLSERVVGLARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGL
RCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSALNRSCRRWFGMTPRQYRAY
GGVSGR"
gene 3448504..3449991
/locus_tag="Rv3083"
CDS 3448504..3449991
/codon_start=1
/transl_table=11
/locus_tag="Rv3083"
/product="Probable monooxygenase (hydroxylase)"
/note="Rv3083, (MTV013.04), len: 495 aa. Probable
monooxygenase, highly similar to other putative
monooxygenases flavin-binding family e.g. AAK48336|MT3969
from Mycobacterium tuberculosis strain CDC1551 (489
aa),FASTA scores: opt: 1692, E(): 4.9e-98, (49.7% identity
in 489 aa overlap); Q9A588|CC2569 from Caulobacter
crescentus (498 aa), FASTA scores: opt: 1684, E():
1.6e-97, (52.25% identity in 484 aa overlap); Q9APW3 from
Pseudomonas aeruginosa (508 aa), FASTA scores: opt: 1603,
E(): 1.8e-92,(49.8% identity in 484 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3083"
/db_xref="EnsemblGenomes-Tr:CCP45892"
/db_xref="GOA:P9WNF7"
/db_xref="InterPro:IPR020946"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WNF7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45892.1"
/translation="MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGT
WDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGL
KVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFG
GRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIF
SLPAVDKISEVLGRFLPDRWVYEFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRR
LGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQIETFTEKGILCKSG
REIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTN
ASWTLKSDIAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDI
MPRQGSKHPWRVLMHYEKDAKILLEDPIDDGVLHFAAAAQDHAAA"
gene 3449997..3450923
/gene="lipR"
/locus_tag="Rv3084"
CDS 3449997..3450923
/codon_start=1
/transl_table=11
/gene="lipR"
/locus_tag="Rv3084"
/product="Probable acetyl-hydrolase/esterase LipR"
/note="Rv3084, (MTV013.05), len: 308 aa. Probable
lipR,N-Acetyl-hydrolase/esterase, similar to other e.g.
Q01109|BAH_STRH from Streptomyces hygroscopicus (299
aa),FASTA scores: opt: 558, E(): 4.1e-26, (40.25% identity
in 246 aa overlap); Q9X8J4|SCE9.22 from Streptomyces
coelicolor (266 aa), FASTA scores: opt: 544, E():
2.5e-25,(36.95% identity in 257 aa overlap); Q56171|DEA
from Streptomyces viridochromogenes (299 aa), FASTA
scores: opt: 532, E(): 1.4e-24, (38.6% identity in 254 aa
overlap); etc. Also similar to
O06350|LIPF|Rv3487c|MTCY13E12.41c (277 aa),FASTA score:
opt: 291, E(): 8.5e-10, (28.5% identity in 239 aa
overlap). May belong to the 'GDXG' family of lipolytic
enzymes."
/db_xref="EnsemblGenomes-Gn:Rv3084"
/db_xref="EnsemblGenomes-Tr:CCP45893"
/db_xref="GOA:P9WK85"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WK85"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45893.1"
/translation="MNLRKNVIRSVLRGARPLFASRRLGIAGRRVLLATLTAGARAPK
GTRFQRVSIAGVPVQRVQPPHAATSGTLIYLHGGAYALGSARGYRGLAAQLAAAAGMT
ALVPDYTRAPHAHYPVALEEMAAVYTRLLDDGLDPKTTVIAGDSAGGGLTLALAMALR
DRGIQAPAALGLICPWADLAVDIEATRPALRDPLILPSMCTEWAPRYVGSSDPRLPGI
SPVYGDMSGLPPIVMQTAGDDPICVDADKIETACAASKTSIEHRRFAGMWHDFHLQVS
LLPEARDAIADLGARLRGHLHQSQGQPRGVVK"
gene 3450920..3451750
/locus_tag="Rv3085"
CDS 3450920..3451750
/codon_start=1
/transl_table=11
/locus_tag="Rv3085"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv3085, (MTV013.06), len: 276 aa. Probable
short-chain dehydrogenase/reductase, similar to various
oxidoreductases in the short chain
dehydrogenases/reductases family e.g. Q9CC98|ML1094 short
chain alcohol dehydrogenase from Mycobacterium leprae (277
aa), FASTA scores: opt: 1059, E(): 4.8e-56, (61.65%
identity in 266 aa overlap); Q9I3H6|PA1537 probable
short-chain dehydrogenase from Pseudomonas aeruginos (295
aa), FASTA scores: opt: 858, E(): 4.7e-44, (48.4% identity
in 285 aa overlap); Q9CBP7|ML1740 possible short chain
reductase from Mycobacterium leprae (312 aa), FASTA
scores: opt: 500, E(): 1e-22, (36.6% identity in 257 aa
overlap); etc. Also similar to mycobacterium proteins
O50460|Rv1245c|MTV006.17c dehydrogenase similar to the
short-chain dehydrogenases/reductases family (276
aa),FASTA scores: opt: 1200, E(): 1.9e-64, (65.2% identity
in 273 aa overlap); and P95101|Rv3057c|MTCY22D7.24
hypothetical dehydrogenase (287 aa). Contains PS00061
Short-chain alcohol dehydrogenase family signature.
Belongs to the short-chain dehydrogenases/reductases (SDR)
family."
/db_xref="EnsemblGenomes-Gn:Rv3085"
/db_xref="EnsemblGenomes-Tr:CCP45894"
/db_xref="GOA:P9WGP9"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGP9"
/inference="protein motif:PROSITE:PS00061"
/protein_id="CCP45894.1"
/translation="MSSFEGKVAVITGAGSGIGRALALNLSEKRAKLALSDVDTDGLA
KTVRLAQALGAQVKSDRLDVAEREAVLAHADAVVAHFGTVHQVYNNAGIAYNGNVDKS
EFKDIERIIDVDFWGVVNGTKAFLPHVIASGDGHIVNISSLFGLIAVPGQSAYNAAKF
AVRGFTEALRQEMLVARHPVKVTCVHPGGIKTAVARNATVADGEDQQTFAEFFDRRLA
LHSPEMAAKTIVNGVAKGQARVVVGLEAKAVDVLARIMGSSYQRLVAAGVAKFFPWAK
"
gene 3451781..3452887
/gene="adhD"
/locus_tag="Rv3086"
CDS 3451781..3452887
/codon_start=1
/transl_table=11
/gene="adhD"
/locus_tag="Rv3086"
/product="Probable zinc-type alcohol dehydrogenase AdhD
(aldehyde reductase)"
/note="Rv3086, (MTV013.07), len: 368 aa. Probable
adhD,zinc-type alcohol dehydrogenase, highly similar to
many e.g. O69045 hypothetical alcohol dehydrogenase from
Rhodococcus rhodochrous (370 aa), FASTA scores: opt:
1255,E(): 8.7e-68, (50.4% identity in 367 aa overlap);
P25406|ADHB_UROHA alcohol dehydrogenase I-B from Uromastyx
hardwickii (Indian spiny-tailed lizard) (375 aa), FASTA
scores: opt: 787, E(): 8.2e-40, (35.9% identity in 373 aa
overlap); P72324||ADHI_RHOSH alcohol dehydrogenase class
III from Rhodobacter sphaeroides (Rhodopseudomonas
sphaeroides) (376 aa), FASTA scores: opt: 787, E():
8.3e-40, (35.1% identity in 379 aa overlap). Also highly
similar to P71818|Rv0761c|MTCY369.06c hypothetical
zinc-type alcohol dehydrogenase-like protein from
Mycobacterium tuberculosis strain H37Rv (375 aa), FASTA
scores: opt: 1186, E(): 1.2e-63, (47.3% identity in 368 aa
overlap). Contains PS00059 Zinc-containing alcohol
dehydrogenases signature. Belongs to the zinc-containing
alcohol dehydrogenase. Possibly requires zinc for its
activity."
/db_xref="EnsemblGenomes-Gn:Rv3086"
/db_xref="EnsemblGenomes-Tr:CCP45895"
/db_xref="GOA:P9WQB9"
/db_xref="InterPro:IPR002328"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR023921"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WQB9"
/inference="protein motif:PROSITE:PS00059"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45895.1"
/translation="MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDL
HLTDGDLPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQ
NLCDMGATILEGCMPDGSFRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLE
TAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPV
AFKRETALKFGATHAFADAASAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIG
KGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQL
MLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH"
gene 3452925..3454343
/locus_tag="Rv3087"
CDS 3452925..3454343
/codon_start=1
/transl_table=11
/locus_tag="Rv3087"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv3087, (MTV013.08), len: 472 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004),
similar to several Mycobacterium tuberculosis proteins
e.g. MTCY08D5.16, MTCY28.26, MTCY493.29c. Also similar to
Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from
Mycobacterium leprae (491 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3087"
/db_xref="EnsemblGenomes-Tr:CCP45896"
/db_xref="GOA:P9WKB1"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WKB1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45896.1"
/translation="MRRLNGVDALMLYLDGGSAYNHTLKISVLDPSTDPDGWSWPKAR
QMFEERAHLLPVFRLRYLPTPLGLHHPIWVEDPEFDLDAHVRRVVCPAPGGMAEFCAL
VEQIYAHPLDRDRPLWQTWVVEGLDGGRVALVTLLHHAYSDGVGVLDMLAAFYNDTPD
EAPVVAPPWEPPPLPSTRQRLGWALRDLPSRLGKIAPTVRAVRDRVRIEREFAKDGDR
RVPPTFDRSAPPGPFQRGLSRSRRFSCESFPLAEVREVSKTLGVTINDVFLACVAGAV
RRYLERCGSPPTDAMVATMPLAVTPAAERAHPGNYSSVDYVWLRADIADPLERLHATH
LAAEATKQHFAQTKDADVGAVVELLPERLISGLARANARTKGRFDTFKNVVVSNVPGP
REPRYLGRWRVDQWFSTGQISHGATLNMTVWSYCDQFNLCVMADAVAVRNTWELLGGF
RASHEELLAAARAQATPKEMAT"
gene 3454340..3455764
/gene="tgs4"
/locus_tag="Rv3088"
CDS 3454340..3455764
/codon_start=1
/transl_table=11
/gene="tgs4"
/locus_tag="Rv3088"
/product="Putative triacylglycerol synthase
(diacylglycerol acyltransferase) Tgs4"
/note="Rv3088, (MTV013.09), len: 474 aa. Putative
tgs4,triacylglycerol synthase (See Daniel et al., 2004),
similar to several Mycobacterium tuberculosis proteins
e.g. MTCY31.23 (505 aa), MTCY13E12.34c (497 aa) and
MTCY493.29c (459 aa). Also similar to
Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from
Mycobacterium leprae (491 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3088"
/db_xref="EnsemblGenomes-Tr:CCP45897"
/db_xref="GOA:P9WKC3"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKC3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45897.1"
/translation="MTRINPIDLSFLLLERANRPNHMAAYTIFEKPKGQKSSFGPRLF
DAYRHSQAAKPFNHKLKWLGTDVAAWETVEPDMGYHIRHLALPAPGSMQQFHETVSFL
NTGLLDRGHPMWECYIIDGIERGRIAILLKVHHALIDGEGGLRAMRNFLSDSPDDTTL
AGPWMSAQGADRPRRTPATVSRRAQLQGQLQGMIKGLTKLPSGLFGVSADAADLGAQA
LSLKARKASLPFTARRTLFNNTAKSAARAYGNVELPLADVKALAKATGTSVNDVVMTV
IDDALHHYLAEHQASTDRPLVAFMPMSLREKSGEGGGNRVSAELVPMGAPKASPVERL
KEINAATTRAKDKGRGMQTTSRQAYALLLLGSLTVADALPLLGKLPSANVVISNMKGP
TEQLYLAGAPLVAFSGLPIVPPGAGLNVTFASINTALCIAIGAAPEAVHEPSRLAELM
QRAFTELQTEAGTTSPTTSKSRTP"
gene 3455761..3457272
/gene="fadD13"
/locus_tag="Rv3089"
CDS 3455761..3457272
/codon_start=1
/transl_table=11
/gene="fadD13"
/locus_tag="Rv3089"
/product="Probable chain-fatty-acid-CoA ligase FadD13
(fatty-acyl-CoA synthetase)"
/note="Rv3089, (MTV013.10), len: 503 aa. Probable
fadD13,Acyl-CoA Synthetase, similar to many e.g.
MTCI28.06,MTCY08D5.09, MTCY06G11.08 from Mycobacterium
tuberculosis strain H37Rv; and to Q9F7P5 predicted
acid--CoA ligase FADD13 from uncultured proteobacterium
EBAC31A08 (504 aa),FASTA scores: opt: 1126, E(): 2.4e-62,
(38.85% identity in 502 aa overlap); Q9EY88|FCS
feruloyl-CoA synthetase from Amycolatopsis sp. strain
HR167 (491 aa), FASTA scores: opt: 1073, E(): 4.5e-59,
(38.5% identity in 504 aa overlap); BAB49118|MLR1843
probable acid-CoA ligase from Rhizobium loti
(Mesorhizobium loti) (495 aa), FASTA scores: opt: 937,E():
1.2e-50, (36.2% identity in 503 aa overlap);
Q9KZC1|SC6F7.21 probable long-chain-fatty-acid-CoA ligase
from Streptomyces coelicolor (511 aa), FASTA scores: opt:
899, E(): 2.8e-48, (36.1% identity in 510 aa overlap);
Q9A5P7|CC2400 putative acid-CoA ligase from Caulobacter
crescentus (496 aa), FASTA scores: opt: 874, E():
9.8e-47,(35.1% identity in 507 aa overlap); etc. Contains
PS00455 Putative AMP-binding domain signature and PS00061
Short-chain alcohol dehydrogenase family signature."
/db_xref="EnsemblGenomes-Gn:Rv3089"
/db_xref="EnsemblGenomes-Tr:CCP45898"
/db_xref="GOA:P9WQ37"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="PDB:3R44"
/db_xref="PDB:3T5B"
/db_xref="PDB:3T5C"
/db_xref="UniProtKB/Swiss-Prot:P9WQ37"
/inference="protein motif:PROSITE:PS00061"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45898.1"
/translation="MKNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCAD
VLTALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGS
KVVIYGAPSAPVIDAIRAQADPPGTVTDWIGADSLAERLRSAAADEPAVECGGDDNLF
IMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFS
AMRGVTLISMPQFDATKVWSLIVEERVCIGGAVPAILNFMRQVPEFAELDAPDFRYFI
TGGAPMPEALIKIYAAKNIEVVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDV
AVRGDDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRTGDIGEIDDEGYL
YIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWGEIAAAIVVADQN
EVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLREQYSATVPK"
gene 3458211..3459098
/locus_tag="Rv3090"
CDS 3458211..3459098
/codon_start=1
/transl_table=11
/locus_tag="Rv3090"
/product="Unknown alanine and valine rich protein"
/note="Rv3090, (MTCY164.01), len: 295 aa. Unknown
Ala-,Val-rich protein. Hydrophobic stretch at N-terminus."
/db_xref="EnsemblGenomes-Gn:Rv3090"
/db_xref="EnsemblGenomes-Tr:CCP45899"
/db_xref="GOA:O05769"
/db_xref="InterPro:IPR001107"
/db_xref="UniProtKB/TrEMBL:O05769"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45899.1"
/translation="MTWQIVFVVICVIVAGVAALFWRLPSDDTTRSRAKTVTIAAVAA
AAVFFFLGCFTIVGTRQFAIMTTFGRPTGVSLNNGFHGKWPWQMTHPMDGAVQIDKYV
KEGNTDQRITVRLGNQSTALADVSIRWQLKQAAAPELFQQYKTFDNVRVNLIERNLSV
ALNEVFAGFNPLDPRNLDVSPLPSLAKRAADILRQDVGGQVDIFDVNVPTIQYDQSTE
DKINQLNQQRAQTSIALEAQRTAEAQAKANEILSRSISDDPNVVVQNCITAAINKGIS
PLGCWPGSSALPTIAVPGR"
gene 3459116..3460807
/locus_tag="Rv3091"
CDS 3459116..3460807
/codon_start=1
/transl_table=11
/locus_tag="Rv3091"
/product="Conserved protein"
/note="Rv3091, (MTCY164.02), len: 563 aa. Conserved
protein, similar in part to O60859 neuropathy target
esterase from Homo sapiens (Human) (1327 aa), FASTA
scores: opt: 177, E(): 0.0062, (30.65% identity in 173 aa
overlap); and Q9I385|PA1640 hypothetical protein from
Pseudomonas aeruginosa (345 aa), FASTA scores: opt: 152,
E(): 0.069,(27.8% identity in 180 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3091"
/db_xref="EnsemblGenomes-Tr:CCP45900"
/db_xref="GOA:I6YB49"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR016035"
/db_xref="UniProtKB/TrEMBL:I6YB49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45900.1"
/translation="MPIPFADGMLSRLGRRGAALDLIEEFEDESGEPPASLSPADLLA
AEPALLLQKMENRLVRHHLANPDVLSGEQLRKLRYILNFARLADFEPGAAGPGGSRGR
GDISVGGQVAPWRSRVVDALYAPLREEPDPVTALEGAKDVLATLVDDQDDQRRVLIER
HGSDFSATELDAEVGYKKLVTVLGGGGGAGFVYIGGMQRLLAAGQVPDYMIGSSFGSI
IGSLVARELPVPIDEYAEWAKTVSYRAILGPERRRSRHGLAGMFTLRFDQFAHTLLSR
ADGERMRMSDLAIPFDVVVAGVRRQPYAALPSRFRHRERSTLTLRSLPFLPIGIGPWV
AARMWQVAAFIDLRVVKPIVISADGATRDVNVVDAASFSSAIPGVLHHETSDPRMLPI
LDELCADQDVAAMVDGGAASNVPVELAWERVRDGRLGTRNACYLAFDCFHPHWDPRHL
WLVPITQAVQLQMVRNLPYADHLVRFEPTLSPVNLAPSAAAIDRACRWGRDSVEPAIA
VTSALLEPTWWEGDRPPAAEPKERTKSAASSMSAVMAAIQAPTGRFRRWRSRHLT"
gene complement(3460814..3461734)
/locus_tag="Rv3092c"
CDS complement(3460814..3461734)
/codon_start=1
/transl_table=11
/locus_tag="Rv3092c"
/product="Probable conserved integral membrane protein"
/note="Rv3092c, (MTCY164.03c), len: 306 aa. Probable
conserved integral membrane protein, highly similar to
Q9RUT5|DR1297 conserved hypothetical protein from
Deinococcus radiodurans (311 aa), FASTA scores: opt:
941,E(): 9.8e-51, (55.65% identity in 309 aa overlap);
Q9A8B8|CC1436 hypothetical protein from Caulobacter
crescentus (314 aa), FASTA scores: opt: 791, E():
1.6e-41,(46.9% identity in 305 aa overlap); and also
highly similar to Q9I2N8|PA1857 hypothetical protein from
Pseudomonas aeruginosa (307 aa), FASTA scores: opt: 373,
E(): 8.1e-16,(40.8% identity in 321 aa overlap);
BAB36119|ECS2696 putative methyl-independent mismatch
repair protein from Escherichia coli strain O157:H7 (305
aa), FASTA scores: opt: 335, E(): 1.7e-13, (39.75%
identity in 307 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3092c"
/db_xref="EnsemblGenomes-Tr:CCP45901"
/db_xref="GOA:I6Y2I9"
/db_xref="InterPro:IPR008526"
/db_xref="UniProtKB/TrEMBL:I6Y2I9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45901.1"
/translation="MSGGLFGLLDHVAVLARLAAASIDDIGAAAGRATAKAAGVVIDD
TAVTPQYVHRITAERELPIIKRIAIGSVRNKLLLILPGALLLSQLVPWLLTPLLMLGA
TYLCYEGAEKVCGVIGGRGHDAAPQVAERELVAGAIRTDFILSAEIMVIALNEVADQP
FVPRLIVLVIVALVITAAVYGVVAVIVQMDDVGLRLTQTASRFGQRIGGGLVAGMPKL
LSALSAVGMGAMLWVGGHIVLVGSDHLGWHAPYRLVHHLDDHLVGSAGGALTWLVSTA
ACAATGLVIGIVVVALVHLVCFRPPRSRSL"
gene complement(3461760..3462764)
/locus_tag="Rv3093c"
CDS complement(3461760..3462764)
/codon_start=1
/transl_table=11
/locus_tag="Rv3093c"
/product="Hypothetical oxidoreductase"
/note="Rv3093c, (MTCY164.04c), len: 334 aa. Hypothetical
oxidoreductase, with some similarity with various
oxidoreductases e.g. Q58929|mer|MJ1534 N5,N10-methylene
tetrahydromethanopterin reductase from Methanococcus
jannaschii (331 aa), FASTA scores: opt: 300, E():
1.1e-10,(24.1% identity in 324 aa overlap); and
Q9ZA30|GRA-ORF29 putative FMN-dependent monooxygenase from
Streptomyces violaceoruber (343 aa), FASTA scores: opt:
264, E(): 1.5e-08, (30.45% identity in 335 aa overlap);
Q9CCV8|ML0348 possible coenzyme F420-dependent
oxidoreductase from Mycobacterium leprae (350 aa), FASTA
scores: opt: 220, E(): 6.4e-06, (26.5% identity in 328 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3093c"
/db_xref="EnsemblGenomes-Tr:CCP45902"
/db_xref="GOA:O05772"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR022526"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:O05772"
/protein_id="CCP45902.1"
/translation="MTDIEVALPFWLDRPDHEATDVALAAADTGFAALWIGEMATYDA
FALATSIGLRTPNMTLKVGPLAVGVRGPVGLALGVSSVASLTGCRVDLALGASSPAIV
AGWHGRPWAHHVPVMRETIECLRSIFTGARVEYSGRHVNSRGFRLRGAAPDTRIALGA
FGPGMIRLAAQHADEVVLNLASPFRVGRVRAAIDSAAAAAGRAAPRLTVCVPVAVNPG
AAAHSQLAAQLAVYLAPPGYGEMFSALGFDGLVRSARSRATRRELAVAVPSELLDRVC
ALGSPDRVAARLRAYADAGADCVAVVPATAEDPGGRVALRALRPGGLYGTAGDNDGRR
"
gene complement(3462761..3463891)
/locus_tag="Rv3094c"
CDS complement(3462761..3463891)
/codon_start=1
/transl_table=11
/locus_tag="Rv3094c"
/product="Conserved hypothetical protein"
/note="Rv3094c, (MTCY164.05c), len: 376 aa. Conserved
hypothetical protein, some similarity with various
proteins e.g. Q9RMR9|NRGC NRGC protein (corresponding gene
seems regulated by NifA) from Bradyrhizobium japonicum
(388 aa),FASTA scores: opt: 677, E(): 5.8e-35, (34.55%
identity in 353 aa overlap); P26698|PIGM_RHOSO pigment
protein from Rhodococcus sp. strain ATCC 21145 (387 aa),
FASTA scores: opt: 480, E(): 1.2e-22, (28.7% identity in
376 aa overlap); Q9F0J3|NCNH hydroxylase from Streptomyces
arenae (405 aa),FASTA scores: opt: 441, E(): 3.3e-20,
(29.25% identity in 352 aa overlap); etc. Equivalent to
AAK47516 from Mycobacterium tuberculosis strain CDC1551
(395 aa) but N-terminus shorter 19 aa."
/db_xref="EnsemblGenomes-Gn:Rv3094c"
/db_xref="EnsemblGenomes-Tr:CCP45903"
/db_xref="GOA:O05773"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013107"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:O05773"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45903.1"
/translation="MNQSETEIEILAEKIARWARARSAEIERDRRLPDELVTRLREAG
LLRATMPREVAAPELAPGRALRCAEAVARGDASAGWCVSIAITSALLVAYLPARSREE
MFGGGRGVAAGVWAPRGTARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVPSV
VALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDGPIVDRPLYRFPVF
GFFALSIGAAALGNARAAIDDLVELAGGKKGLGSTRTLAERSATQAAAATAESALGAA
RALFYEVIEAAWQVSHDAEAVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYD
NAPLQRRFRDAFTATAHFQVNEASRELPGRVLLDQPADVSML"
gene 3463973..3464449
/locus_tag="Rv3095"
CDS 3463973..3464449
/codon_start=1
/transl_table=11
/locus_tag="Rv3095"
/product="Hypothetical transcriptional regulatory protein"
/note="Rv3095, (MTCY164.06), len: 158 aa. Possible
regulatory protein, because contains possible
helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to
hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas
aeruginosa (159 aa), FASTA scores: opt: 486, E():
1.6e-25,(45.95% identity in 148 aa overlap); Q9AAF6|CC0645
from Caulobacter crescentus (188 aa), FASTA scores: opt:
479,E(): 5.3e-25, (45.75% identity in 153 aa overlap);
Q9K408|2SCG61.07 from Streptomyces coelicolor (157
aa),FASTA scores: opt: 407, E(): 2.8e-20, (43.9% identity
in 139 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3095"
/db_xref="EnsemblGenomes-Tr:CCP45904"
/db_xref="GOA:P9WMG3"
/db_xref="InterPro:IPR002577"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:P9WMG3"
/protein_id="CCP45904.1"
/translation="MAVSDLSHRFEGESVGRALELVGERWTLLILREAFFGVRRFGQL
ARNLGIPRPTLSSRLRMLVEVGLFDRVPYSSDPERHEYRLTEAGRDLFAAIVVLMQWG
DEYLPRPEGPPIKLRHHTCGEHADPRLICTHCGEEITARNVTPEPGPGFKAKLASS"
gene 3464547..3465686
/locus_tag="Rv3096"
CDS 3464547..3465686
/codon_start=1
/transl_table=11
/locus_tag="Rv3096"
/product="Conserved hypothetical protein"
/note="Rv3096, (MTCY164.07), len: 379 aa. Hypothetical
protein, with slight similarity to several proteins e.g.
Q09671|OYEB_SCHPO|SPAC5H10.10 putative NADPH dehydrogenase
C5H10.10 (old yellow enzyme homolog) from
Schizosaccharomyces pombe (Fission yeast) (392 aa), FASTA
scores: opt: 125, E(): 1.1, (25.45% identity in 165 aa
overlap); and Q12603|XYNA_DICTH beta-1,4-xylanase
(endo-1,4-beta-xylanase) from Dictyoglomus thermophilum
(352 aa), FASTA scores: opt: 124, E(): 1.2, (25.65%
identity in 195 aa overlap); etc. Contains glycosyl
hydrolases family 5 signature (PS00659). Predicted to be
an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3096"
/db_xref="EnsemblGenomes-Tr:CCP45905"
/db_xref="InterPro:IPR017853"
/db_xref="UniProtKB/TrEMBL:I6YB54"
/inference="protein motif:PROSITE:PS00659"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45905.1"
/translation="MHRRTALKLPLLLAAGTVLGQAPRAAAEEPGRWSADRAHRWYQA
HGWLVGANYITSNAINQLEMFQPGTYDPRRIDNELGLARFHGFNTVRVFLHDLLWAQD
APGFQTRLAQFVAIAARYHIKPLFVLFDSCWDPLPRPGRQRAPRAGVHNSGWVQSPGA
ERLDDRRYASTLYNYVTGVLGQFRNDDRVLGWDLWNEPDNPARVYRKVERKDKLERVA
ELLPQVFRWARTVDPVQPLTSGVWQGNWGDPGRRSTISAIQLDNADVITFHSYAAPAE
FEGRIAELAPLQRPILCTEYLARSQGSTVEGILPIAKRHNVGAFNWGLVAGKTQTYLP
WDSWDHPYRAPPKVWFHDLLHPNGRPYRDGEVQTIRKLNGMPSQD"
gene complement(3465778..3467091)
/gene="lipY"
/gene_synonym="PE_PGRS63"
/locus_tag="Rv3097c"
CDS complement(3465778..3467091)
/codon_start=1
/transl_table=11
/gene="lipY"
/gene_synonym="PE_PGRS63"
/locus_tag="Rv3097c"
/product="PE-PGRS family protein, triacylglycerol lipase
LipY (esterase/lipase) (triglyceride lipase)
(tributyrase)"
/note="Rv3097c, (MTCY164.08c), len: 437 aa.
LipY,triacylglycerol lipase. Belongs to the
hormone-sensitive lipase family (See Deb et al., 2006) and
member of the M. tuberculosis PE-family PGRS subfamily of
gly-rich proteins (see citation below); N-terminal part
similar to N-terminus of M. tuberculosis PE-PGRS family
members e.g. Q10637|Y03A_MYCTU hypothetical glycine-rich
49.6 kDa protein (603 aa). Other relatives include
MTCY1A11.25c; MTCY21B4.13c; MTCY270.06; MTCY359.33;
MTC1A11.04. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3097c"
/db_xref="EnsemblGenomes-Tr:CCP45906"
/db_xref="GOA:I6Y2J4"
/db_xref="InterPro:IPR000084"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:I6Y2J4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45906.1"
/translation="MVSYVVALPEVMSAAATDVASIGSVVATASQGVAGATTTVLAAA
EDEVSAAIAALFSGHGQDYQALSAQLAVFHERFVQALTGAAKGYAAAELANASLLQSE
FASGIGNGFATIHQEIQRAPTALAAGFTQVPPFAAAQAGIFTGTPSGAAGFDIASLWP
VKPLLSLSALETHFAIPNNPLLALIASDIPPLSWFLGNSPPPLLNSLLGQTVQYTTYD
GMSVVQITPAHPTGEYVVAIHGGAFILPPSIFHWLNYSVTAYQTGATVQVPIYPLVQE
GGTAGTVVPAMAGLISTQIAQHGVSNVSVVGDSAGGNLALAAAQYMVSQGNPVPSSMV
LLSPWLDVGTWQISQAWAGNLAVNDPLVSPLYGSLNGLPPTYVYSGSLDPLAQQAVVL
EHTAVVQGAPFSFVLAPWQIHDWILLTPWGLLSWPQINQQLGIAA"
gene complement(3467210..3467662)
/locus_tag="Rv3098c"
CDS complement(3467210..3467662)
/codon_start=1
/transl_table=11
/locus_tag="Rv3098c"
/product="Hypothetical protein"
/note="Rv3098c, (MTCY164.09c), len: 150 aa. Hypothetical
unknown protein (shorter version of MTCY164.09c). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3098c"
/db_xref="EnsemblGenomes-Tr:CCP45907"
/db_xref="UniProtKB/TrEMBL:O05776"
/protein_id="CCP45907.1"
/translation="MASLRIAEVDPVDRSPNHHASGSVETSSSRSRSASVRACLIHTS
RSSSCSARRMTSLLRSPLRIAALMICSSFSVGRKPMVAVMSTTIADVAQSYSNCSTHS
GTPTPAFAASFLLDAINAPRVIAGRFASESVRFPAAAPHGSVPSRLPV"
gene 3467606..3467926
/locus_tag="Rv3098A"
CDS 3467606..3467926
/codon_start=1
/transl_table=11
/locus_tag="Rv3098A"
/product="PemK-like protein"
/note="Rv3098A, len: 106 aa. PemK-like protein."
/db_xref="EnsemblGenomes-Gn:Rv3098A"
/db_xref="EnsemblGenomes-Tr:CCP45908"
/db_xref="GOA:V5QRX7"
/db_xref="InterPro:IPR003477"
/db_xref="InterPro:IPR011067"
/db_xref="UniProtKB/Swiss-Prot:V5QRX7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45908.1"
/translation="MVIRGAVYRVDFGDAKRGHEQRGRRYAVVISPGSMPWSVVTVVP
TSTSAQPAVFRPELEVMGTKTRFLVDQIRTIGIVYVHGDPVDYLDRDQMAKVEHAVAR
YLGL"
gene complement(3467967..3468334)
/gene="ssr"
misc_RNA complement(3467967..3468334)
/gene="ssr"
/product="10Sa RNA"
/note="ssr, match to EM_BA:MT10SARNA X60301 M.tuberculosis
gene for 10Sa RNA. Ends changed since first submission
(-239 nt)."
gene complement(3468413..3469264)
/locus_tag="Rv3099c"
CDS complement(3468413..3469264)
/codon_start=1
/transl_table=11
/locus_tag="Rv3099c"
/product="Conserved protein"
/note="Rv3099c, (MTCY164.10c), len: 283 aa. Conserved
protein, some similarity with hypothetical proteins e.g.
Q9XA69|SCGD3.09 from Streptomyces coelicolor (274
aa),FASTA scores: opt: 384, E(): 1.8e-17, (32.7% identity
in 269 aa overlap); and P71606|Y036_MYCTU|Rv0036c from
Mycobacterium tuberculosis strain H37Rv (257 aa), FASTA
scores: opt: 179, E(): 0.00024, (25.85% identity in 205 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3099c"
/db_xref="EnsemblGenomes-Tr:CCP45909"
/db_xref="GOA:O05777"
/db_xref="InterPro:IPR010872"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR024344"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/TrEMBL:O05777"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45909.1"
/translation="MTTPGRPLTTLDKSDVLAGLFAVWHSLDALLDGLLETDWQATSP
LPGWDVKAVVSHIIGTESFLLGIAAPEPDTDVSALAHVRNPIGVMNECWVRHLGTESG
VGLLERFRAVTSQRRKVLASLSDDEWNAPTTTPSGPDSYGRFMRIRIFDCWMHEQDIR
AAVQRPSSDDELGGPASPLVLDEIAATMGFVVGKLAKAPDGSRVLLELTGPLSRSIRV
SVDGRARVVDDFGGPAPTATIRLDGLQFTRLAGGRPMSPARSQDVELGGDKELAGHIL
ERLNFVI"
gene complement(3469301..3469783)
/gene="smpB"
/locus_tag="Rv3100c"
CDS complement(3469301..3469783)
/codon_start=1
/transl_table=11
/gene="smpB"
/locus_tag="Rv3100c"
/product="Probable SSRA-binding protein SmpB"
/note="Rv3100c, (MTCY164.11c), len: 160 aa. Probable
smpB,small protein b related to several bacterial small
protein b homologs e.g.
O32881|SSRP_MYCLE|ML0671|MLCB1779.19c from Mycobacterium
leprae (160 aa), FASTA scores: opt: 914, E(): 1.1e-52,
(84.9% identity in 159 aa overlap); Q9L1S9|SMPB from
Streptomyces coelicolor (159 aa), FASTA scores: opt: 568,
E(): 3.3e-30, (55.15% identity in 145 aa overlap);
O32230|SSRP_BACSU from Bacillus subtilis (156 aa), FASTA
scores: opt: 511, E(): 1.7e-26, (47.05% identity in 153 aa
overlap); etc. Belongs to the SSRP family. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3100c"
/db_xref="EnsemblGenomes-Tr:CCP45910"
/db_xref="GOA:P9WGD3"
/db_xref="InterPro:IPR000037"
/db_xref="InterPro:IPR020081"
/db_xref="InterPro:IPR023620"
/db_xref="UniProtKB/Swiss-Prot:P9WGD3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45910.1"
/translation="MSKSSRGGRQIVASNRKARHNYSIIEVFEAGVALQGTEVKSLRE
GQASLADSFATIDDGEVWLRNAHIPEYRHGSWTNHEPRRNRKLLLHRRQIDTLVGKIR
EGNFALVPLSLYFAEGKVKVELALARGKQARDKRQDMARRDAQREVLRELGRRAKGMT
"
gene complement(3469786..3470679)
/gene="ftsX"
/locus_tag="Rv3101c"
CDS complement(3469786..3470679)
/codon_start=1
/transl_table=11
/gene="ftsX"
/locus_tag="Rv3101c"
/product="Putative cell division protein FtsX (septation
component-transport integral membrane protein ABC
transporter)"
/note="Rv3101c, (MTCY164.12c), len: 297 aa. Putative
ftsX,cell division protein, septation component transport
integral membrane protein ABC transporter (see citations
below), equivalent to
O32882|FTSX_MYCLE|ML0670|MLCB1779.20c cell division
protein from Mycobacterium leprae (297 aa),FASTA scores:
opt: 1597, E(): 9.2e-93, (80.8% identity in 297 aa
overlap); and similar to others e.g. Q9L1S7|SCE59.27c from
Streptomyces coelicolor (305 aa),FASTA scores: opt: 585,
E(): 1.9e-29, (34.55% identity in 304 aa overlap);
O34876|FTSX_BACSU from Bacillus subtilis (296 aa), FASTA
scores: opt: 318, E(): 9.1e-13, (24.65% identity in 300 aa
overlap); Q9K6X3|FTSX|BH3601 from Bacillus halodurans (298
aa), FASTA scores: opt: 290, E(): 5.2e-11, (22.75%
identity in 299 aa overlap); etc. Belongs to the FTSX
family."
/db_xref="EnsemblGenomes-Gn:Rv3101c"
/db_xref="EnsemblGenomes-Tr:CCP45911"
/db_xref="GOA:P9WG19"
/db_xref="InterPro:IPR003838"
/db_xref="InterPro:IPR004513"
/db_xref="InterPro:IPR040690"
/db_xref="PDB:4N8N"
/db_xref="PDB:4N8O"
/db_xref="UniProtKB/Swiss-Prot:P9WG19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45911.1"
/translation="MRFGFLLNEVLTGFRRNVTMTIAMILTTAISVGLFGGGMLVVRL
ADSSRAIYLDRVESQVFLTEDVSANDSSCDTTACKALREKIETRSDVKAVRFLNRQQA
YDDAIRKFPQFKDVAGKDSFPASFIVKLENPEQHKDFDTAMKGQPGVLDVLNQKELID
RLFAVLDGLSNAAFAVALVQAIGAILLIANMVQVAAYTRRTEIGIMRLVGASRWYTQL
PFLVEAMLAATMGVGIAVAGLMVVRALFLENALNQFYQANLIAKVDYADILFITPWLL
LLGVAMSGLTAYLTLRLYVRR"
gene complement(3470680..3471369)
/gene="ftsE"
/locus_tag="Rv3102c"
CDS complement(3470680..3471369)
/codon_start=1
/transl_table=11
/gene="ftsE"
/locus_tag="Rv3102c"
/product="Putative cell division ATP-binding protein FtsE
(septation component-transport ATP-binding protein ABC
transporter)"
/note="Rv3102c, (MTCY164.13_2c), len: 229 aa. Putative
ftsE, cell division protein, septation component transport
ATP-binding protein ABC transporter (see citations
below),equivalent to O32883|FTSE|ML0669 cell division
ATP-binding protein from Mycobacterium leprae (229 aa),
FASTA scores: opt: 1384, E(): 2.4e-74, (91.7% identity in
229 aa overlap); and similar to Q9L1S6|FTSE from
Streptomyces coelicolor (229 aa), FASTA scores: opt: 914,
E(): 8.7e-47,(62.85% identity in 226 aa overlap);
Q9A0S4|FTSE|SPY0644 from Streptococcus pyogenes (230 aa),
FASTA scores: opt: 866, E(): 5.7e-44, (57.9% identity in
228 aa overlap); Q9CGX0|FTSE from Lactococcus lactis
(subsp. lactis) (Streptococcus lactis) (230 aa), FASTA
scores: opt: 792,E(): 1.3e-39, (52.2% identity in 228 aa
overlap); etc. Other relatives from Mycobacterium
tuberculosis include: MTCY253.24; MTCY16B7.10;
MTCY9C4.04c; MTCY50.01; MTCY05A6.09c; MTCY04C12.31.
Contains PS00017 ATP/GTP-binding site motif A (P-loop) and
ABC transporters family signature (PS00211). Belongs to
the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv3102c"
/db_xref="EnsemblGenomes-Tr:CCP45912"
/db_xref="GOA:O05779"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005286"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:O05779"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45912.1"
/translation="MITLDHVTKQYKSSARPALDDINVKIDKGEFVFLIGPSGSGKST
FMRLLLAAETPTSGDVRVSKFHVNKLRGRHVPKLRQVIGCVFQDFRLLQQKTVYDNVA
FALEVIGKRTDAINRVVPEVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVL
LADEPTGNLDPETSRDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELSLGRLVR
DEQRGVYGMDR"
gene complement(3471413..3471850)
/locus_tag="Rv3103c"
CDS complement(3471413..3471850)
/codon_start=1
/transl_table=11
/locus_tag="Rv3103c"
/product="Hypothetical proline-rich protein"
/note="Rv3103c, (MTCY164.13c), len: 145 aa. Hypothetical
unknown pro-rich protein, with some similarity to
Proline-rich proteins e.g. Q39789 proline-rich cell wall
protein from Gossypium hirsutum (Upland cotton) (214
aa),FASTA scores: opt: 267, E(): 0.00014, (40% identity in
110 aa overlap). Equivalent to AAK47525 from M.
tuberculosis strain CDC1551 (158 aa) but shorter 13 aa."
/db_xref="EnsemblGenomes-Gn:Rv3103c"
/db_xref="EnsemblGenomes-Tr:CCP45913"
/db_xref="GOA:O05780"
/db_xref="UniProtKB/TrEMBL:O05780"
/protein_id="CCP45913.1"
/translation="MKLSNQKRHWPGYLFGRIRTSTLVLIAAFLAVWWIYETYRPQAP
GPGDSPPTQVVPPGFVPDPDYTWVPRTRVQPPTVKATPTTTSSTPPVSPPETTTDSAV
PPPFELPPPFGPGTTTPTPPAPLPQPGPGPTAGTYPKSEPPTR"
gene complement(3471852..3472778)
/locus_tag="Rv3104c"
CDS complement(3471852..3472778)
/codon_start=1
/transl_table=11
/locus_tag="Rv3104c"
/product="Possible conserved transmembrane protein"
/note="Rv3104c, (MTCY164.14c), len: 308 aa. Possible
conserved transmembrane protein, with some similarity to
hypthetical proteins e.g. Q9L1X9|SC8E4A.26 putative
membrane protein from Streptomyces coelicolor (408
aa),FASTA scores: opt: 514, E(): 4.3e-25, (35.2% identity
in 287 aa overlap); Q9XA89|CF43A.26c hypothetical 36.1 KDA
protein from Streptomyces coelicolor (333 aa), FASTA
scores: opt: 482, E(): 3.7e-23, (34.9% identity in 301 aa
overlap); Q55987|SLR0765 hypothetical 68.9 KDA protein
from Synechocystis sp. strain PCC 6803 (617 aa), FASTA
scores: opt: 429, E(): 1.3e-19, (30.6% identity in 278 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3104c"
/db_xref="EnsemblGenomes-Tr:CCP45914"
/db_xref="GOA:O05781"
/db_xref="InterPro:IPR006685"
/db_xref="InterPro:IPR010920"
/db_xref="InterPro:IPR011014"
/db_xref="InterPro:IPR011066"
/db_xref="InterPro:IPR023408"
/db_xref="UniProtKB/TrEMBL:O05781"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45914.1"
/translation="MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVL
AARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEV
IDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGS
PENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADL
GRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAG
RQLRVLVIRALTRAGIVTAADARAAVAESPEQ"
gene complement(3472768..3473904)
/gene="prfB"
/locus_tag="Rv3105c"
CDS complement(3472768..3473904)
/codon_start=1
/transl_table=11
/gene="prfB"
/locus_tag="Rv3105c"
/product="Probable peptide chain release factor 2 PrfB
(RF-2)"
/note="Rv3105c, (MTCY164.15c), len: 378 aa. Probable
prfB,peptide chain release factor 2, equivalent to
O32885|RF2_MYCLE|ML0667|MLCB1779.24c from Mycobacterium
leprae, FASTA scores: opt: 2197, E(): 1.8e-126, (90.05%
identity in 372 aa overlap); and also similar to other
peptide chain release factors e.g. Q9L1S3|PRFB from
Streptomyces coelicolor (368 aa), FASTA scores: opt:
1674,E(): 1.2e-94, (69.3% identity in 365 aa overlap);
O67695|RF2_AQUAE|PRFB|AQ_1840 from Aquifex aeolicus (373
aa), FASTA scores: opt: 1082, E(): 1.3e-58, (44.45%
identity in 369 aa overlap); P28367|RF2_BACSU from B.
subtilis (366 aa), FASTA scores: opt: 1030, E():
1.9e-55,(44.0% identity in 359 aa overlap); etc. Also
related to Q10605|MTCY373.19|RF1_MYCTU|Rv1299|MT1338
peptide chain release factor 1 (rf-1) (357 aa), FASTA
scores: opt: 646,E(): 1.1e-34, (38.6% identity in 350 aa
overlap). Contains prokaryotic-type class I peptide chain
release factors signature (PS00745). Belongs to the
prokaryotic and mitochondrial release factors family."
/db_xref="EnsemblGenomes-Gn:Rv3105c"
/db_xref="EnsemblGenomes-Tr:CCP45915"
/db_xref="GOA:P9WHG1"
/db_xref="InterPro:IPR000352"
/db_xref="InterPro:IPR004374"
/db_xref="InterPro:IPR005139"
/db_xref="UniProtKB/Swiss-Prot:P9WHG1"
/inference="protein motif:PROSITE:PS00745"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45915.1"
/translation="MPVTLAAVDPDRQADIAALDCTLTTVERVLDVEGLRSRIEKLEH
EASDPHLWDDQTRAQRVTSELSHTQGELRRVEELRRRLDDLPVLYELAAEEAGAAAAD
AVAEADAELKSLRADIEATEVRTLLSGEYDEREALVTIRSGAGGVDAADWAEMLMRMY
IRWAEQHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQ
SRRQTSFAEVEVLPVVETTDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPS
GIVVTCQNEKSQLQNKIAAMRVLQAKLLERKRLEERAELDALKADGGSSWGNQMRSYV
LHPYQMVKDLRTEYEVGNPAAVLDGDLDGFLEAGIRWRNRRNDD"
gene 3474007..3475377
/gene="fprA"
/locus_tag="Rv3106"
CDS 3474007..3475377
/codon_start=1
/transl_table=11
/gene="fprA"
/locus_tag="Rv3106"
/product="NADPH:adrenodoxin oxidoreductase FprA
(NADPH-ferredoxin reductase)"
/note="Rv3106, (MTCY164.16), len: 456 aa.
FprA,NADPH:adrenodoxin oxidoreductase (NADPH-ferredoxin
reductase) (see citations below), equivalent to
O32886|MLCB1779.25|FPRA|ML0666 from Mycobacterium leprae
(456 aa), FASTA scores: opt: 2505, E(): 1.2e-142, (81,05%
identity in 459 aa overlap); also similar to other
NADPH:adrenodoxin oxidoreductases e.g. Q9RX19|DR0496 from
Deinococcus radiodurans (479 aa), FASTA scores: opt:
1331,E(): 2.6e-72, (48.9% identity in 454 aa overlap);
Q9RK35|SCF15.02 from Streptomyces coelicolor (454
aa),FASTA scores: opt: 1102, E(): 1.3e-58, (41.35%
identity in 462 aa overlap); P82861 from Salvelinus
fontinalis (Brook trout) (498 aa), FASTA scores: opt: 827,
E(): 4e-42, (41.3% identity in 460 aa overlap);
Q9V3T9|ADRO_DROME from Drosophila melanogaster (Fruit fly)
(466 aa), FASTA scores: opt: 790, E(): 6.3e-40, (39.45%
identity in 459 aa overlap); etc. Also similar to
Q10547|FPRB|Rv0886|MT0909|MTCY31.14 from Mycobacterium
tuberculosis strain H37Rv (575 aa), FASTA scores: opt:
894,E(): 4.4e-46, (42.05% identity in 459 aa overlap).
Cofactor: FAD"
/db_xref="EnsemblGenomes-Gn:Rv3106"
/db_xref="EnsemblGenomes-Tr:CCP45916"
/db_xref="GOA:P9WIQ3"
/db_xref="InterPro:IPR021163"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="PDB:1LQT"
/db_xref="PDB:1LQU"
/db_xref="PDB:2C7G"
/db_xref="UniProtKB/Swiss-Prot:P9WIQ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45916.1"
/translation="MRPYYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPT
PWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELSERYDAVIY
AVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPDLSGARAVVIGNGNVAL
DVARILLTDPDVLARTDIADHALESLRPRGIQEVVIVGRRGPLQAAFTTLELRELADL
DGVDVVIDPAELDGITDEDAAAVGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPI
EIKGKRKVERIVLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPF
DDQSGTIPNVGGRINGSPNEYVVGWIKRGPTGVIGTNKKDAQDTVDTLIKNLGNAKEG
AECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFERAAGEPHGRPRVKLASLAEL
LRIGLG"
gene complement(3475378..3476961)
/gene="agpS"
/locus_tag="Rv3107c"
CDS complement(3475378..3476961)
/codon_start=1
/transl_table=11
/gene="agpS"
/locus_tag="Rv3107c"
/product="Possible alkyldihydroxyacetonephosphate synthase
AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate
synthase)"
/note="Rv3107c, (MTCY164.17c), len: 527 aa. Possible
agpS,alkyl-dihydroxyacetonephosphate synthase, similar to
others and some various enzymes e.g. AAK46595|MT2311
putative alkyl-dihydroxyacetonephosphate synthase from
Mycobacterium tuberculosis strain CDC1551 (529 aa), FASTA
scores: opt: 1052, E(): 2.1e-58, (37.1% identity in 542 aa
overlap); Q9RJ97|SCF91.28c putative flavoprotein from
Streptomyces coelicolor (530 aa), FASTA scores: opt: 972,
E(): 2.2e-53,(36.2% identity in 544 aa overlap);
O96759|ADAS_DICDI alkyldihydroxyacetonephosphate synthase
from Dictyostelium discoideum (Slime mold) (611 aa), FASTA
scores: opt: 617,E(): 4.5e-31, (33.95% identity in 480 aa
overlap); O97157|ADAS_TRYBB alkyldihydroxyacetonephosphate
synthase from Trypanosoma brucei (613 aa), FASTA scores:
opt: 567,E(): 6.2e-28, (29.15% identity in 521 aa
overlap); etc. Also similar to O53525|Rv2251|MTV022.01
hypothetical 49.8 KDA protein from Mycobacterium
tuberculosis strain H37Rv (475 aa), FASTA scores: opt:
1019, E(): 2.3e-56, (38.6% identity in 487 aa overlap).
Belongs to the FAD-binding oxidoreductase/transferase
family 4. Cofactor: FAD (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3107c"
/db_xref="EnsemblGenomes-Tr:CCP45917"
/db_xref="GOA:O05784"
/db_xref="InterPro:IPR004113"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016164"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:O05784"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45917.1"
/translation="MRSWWGWGTVEDALSDQETQALQSRVAALVSGHDLSDHPPPDLT
ALGLAAPRVSPPASLAALCSSDLVDRAGHARGKAYRDIARNLQGQLDHLPDLIARPRS
EQDVIDVLDWCAREGIAVIPYGGGSSVVGGVEPRFDEPVVTVDVTAMSAVLEIDRVSR
AARIQAGAFGPSIEHQLRPHDLTLRHFPQSFGFSTLGGWLATRSGGHFATLYTHIDDL
TESLRIVTPVGISESRRLPGSGAGPSPDRLFLGSEGTLGIITEAWMRLQHRPRWQVTV
SVVFDDWAAAVAATRTIAQAGLYPANCRLLDPAEALLNAGTSVGGGLLVLAFESADHP
IDPWLHRAVAITAEHGGTVTAQRSRGTTSDATEHNAAANWRSAFLRMPYQRDALVRRG
VIAETFETACTWDGFDTLHAAVTDAARTAIWKVCGTGVVTCRFTHVYPDGPAPYYGIY
AGGRWGSLDAQWDEIKAAVSEAISASGGTITHHHAVGRDHRAWYDRQRPDPFAAALRA
AKSALDPAGILNPGVLLGR"
gene 3477060..3477500
/locus_tag="Rv3108"
CDS 3477060..3477500
/codon_start=1
/transl_table=11
/locus_tag="Rv3108"
/product="Hypothetical protein"
/note="Rv3108, (MTCY164.18), len: 146 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3108"
/db_xref="EnsemblGenomes-Tr:CCP45918"
/db_xref="UniProtKB/TrEMBL:O05785"
/protein_id="CCP45918.1"
/translation="MTPNAASTGDSAKNTITGCCLITARALVARTRSISLPGMPFRMP
ADYHNASSDEPTNRHPWPAPARCCRHEWRTMRRTNACDRRRFGLSLTIHEDACRIISV
VPVVLEVRRAEPAHPATPYPEPLARCSRSPGLNESSHMSGRIPP"
gene 3477649..3478728
/gene="moaA1"
/gene_synonym="moaA"
/locus_tag="Rv3109"
CDS 3477649..3478728
/codon_start=1
/transl_table=11
/gene="moaA1"
/gene_synonym="moaA"
/locus_tag="Rv3109"
/product="Probable molybdenum cofactor biosynthesis
protein A MoaA1"
/note="Rv3109, (MTCY164.19), len: 359 aa. Probable
moaA1,molybdenum cofactor biosynthesis protein, highly
similar to others e.g. P39757|MOAA_BACSU|NARA|NARAB from
Bacillus subtilis (341 aa), FASTA scores: opt: 810, E():
6.2e-44,(39.75% identity in 327 aa overlap);
O67929|MOAA_AQUAE|AQ_2183 from Aquifex aeolicus (320
aa),FASTA scores: opt: 794, E(): 6e-43, (40.55% identity
in 323 aa overlap); Q9ZIM6|MOAA_STACA from Staphylococcus
carnosus (340 aa), FASTA scores: opt: 783, E(): 3.2e-42,
(38.65% identity in 326 aa overlap); etc. Also highly
similar to O53143|MOAA3|MOA3_MYCTU|MT3427 molybdenum
cofactor biosynthesis protein A 3 from Mycobacterium
tuberculosis strain F4 (378 aa), FASTA scores: opt: 1762,
E(): 4.7e-104,(74.3% identity in 350 aa overlap); and
similar to O53881|MOA2_MYCTU|MOAA2|Rv0869c|MT0892|MTV043.6
2 molybdenum cofactor biosynthesis protein A 2 from
Mycobacterium tuberculosis strain H37Rv (360 aa), FASTA
scores: opt: 657,E(): 3e-34, (36.55% identity in 309 aa
overlap). Belongs to the MoaA / NifB / PqqE family. Note
that previously known as moaA. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3109"
/db_xref="EnsemblGenomes-Tr:CCP45919"
/db_xref="GOA:P9WJS3"
/db_xref="InterPro:IPR000385"
/db_xref="InterPro:IPR006638"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR010505"
/db_xref="InterPro:IPR013483"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/Swiss-Prot:P9WJS3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45919.1"
/translation="MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYC
MPEEHYTWLPRQDLLSVKEISAIVDVFLSVGVSKVRITGGEPLIRPDLPEIVRTLSAK
VGEDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVSLDTLQPERFKAISQRNSHDKV
IAGIKAVAAAGFTDTKIDTTVMRGANHDELADLIEFARTVNAEVRFIEYMDVGGATHW
AWEKVFTKANMLESLEKRYGRIEPLPKHDTAPANRYALPDGTTFGIIASTTEPFCATC
DRSRLTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQ
RERGVFLPLSTLKADPHLEMHTRGG"
gene 3478779..3479174
/gene="moaB1"
/gene_synonym="moaB"
/locus_tag="Rv3110"
CDS 3478779..3479174
/codon_start=1
/transl_table=11
/gene="moaB1"
/gene_synonym="moaB"
/locus_tag="Rv3110"
/product="Probable pterin-4-alpha-carbinolamine
dehydratase MoaB1 (PHS) (4-alpha-hydroxy-tetrahydropterin
dehydratase) (pterin-4-a-carbinolamine dehydratase)
(phenylalanine hydroxylase-stimulating protein) (PHS)
(pterin carbinolamine dehydratase) (PCD)"
/note="Rv3110, (MTCY164.20), len: 131 aa. Probable
moaB1,pterin-4-alpha-carbinolamine dehydratase, similar to
others e.g. P73790|SSL2296 from Synechocystis sp. strain
PCC 6803 (96 aa), FASTA scores: opt: 195, E(): 6.2e-07,
(35.4% identity in 96 aa overlap); Q9PAB4|PHS_XYLFA|XF2604
from Xylella fastidiosa (116 aa), FASTA scores: opt: 187,
E(): 2.6e-06, (36.25% identity in 102 aa overlap);
AAK42360|Q97WM6|PHS_SULSO|SSO2187 from Sulfolobus
solfataricus (114 aa), FASTA scores: opt: 177, E():
1.3e-05, (34.6% identity in 78 aa overlap); etc. Also
highly similar to AAK47768|MT3426
pterin-4-alpha-carbinolamine dehydratase from
Mycobacterium tuberculosis CDC1551 (124 aa), FASTA scores:
opt: 383, E(): 7.7e-20, (50.0% identity in 110 aa
overlap). Belongs to the pterin-4-alpha-carbinolamine
dehydratase family. Note that previously known as moaB.
This region is a possible MT-complex-specific genomic
island (See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3110"
/db_xref="EnsemblGenomes-Tr:CCP45920"
/db_xref="GOA:Q6MX13"
/db_xref="InterPro:IPR001533"
/db_xref="InterPro:IPR036428"
/db_xref="UniProtKB/TrEMBL:Q6MX13"
/protein_id="CCP45920.1"
/translation="MTVSTPEQHEQRASHDASEGKHNVCQGRLAALADAAVSEKLGAL
PGWQLLDMRLSRAFQCTNFDQSIDFMNRVASIANDINHHPDIAVLDKRSVRVTAWTRK
LGYLTDIDFDLAASVEAMYATEFADRPAR"
gene 3479171..3479683
/gene="moaC1"
/gene_synonym="moaC"
/locus_tag="Rv3111"
CDS 3479171..3479683
/codon_start=1
/transl_table=11
/gene="moaC1"
/gene_synonym="moaC"
/locus_tag="Rv3111"
/product="Probable molybdenum cofactor biosynthesis
protein C MoaC1"
/note="Rv3111, (MTCY164.21), len: 170 aa. Probable
moaC1,molybdopterin cofactor biosynthesis protein, highly
similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas
aeruginosa (160 aa), FASTA scores: opt: 576, E():
2.2e-29,(62.1% identity in 153 aa overlap); Q9ZFA6|MOAC
from Rhodobacter sphaeroides (Rhodopseudomonas
sphaeroides) (159 aa), FASTA scores: opt: 541, E():
3.4e-27, (59.85% identity in 157 aa overlap);
BAB48171|MLR0616 from Rhizobium loti (Mesorhizobium loti)
(160 aa), FASTA scores: opt: 531, E(): 1.5e-26, (58.75%
identity in 160 aa overlap); P30747|MOAC_ECOLI|CHLA3|B0783
from Escherichia coli strain K12 (160 aa), FASTA scores:
opt: 527, E(): 2.6e-26, (58.5% identity in 159 aa
overlap); etc. Also highly similar to
O53376|MOAC3|Rv3324c|MTV016.24c putative molybdenum
cofactor biosynthesis protein C 3 from Mycobacterium
tuberculosis (177 aa), FASTA scores: opt: 738, E():
1.7e-39, (71.5% identity in 165 aa overlap);
AAK47767|MT3425 molybdopterin cofactor biosynthesis
protein C from Mycobacterium tuberculosis strain CDC1551
(184 aa),FASTA scores: opt: 734, E(): 3.1e-39, (71.8%
identity in 163 aa overlap); and Rv0864|MOAC2|MTV043.57
putative molybdenum cofactor biosynthesis protein C 2 (167
aa). Note that previously known as moaC. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3111"
/db_xref="EnsemblGenomes-Tr:CCP45921"
/db_xref="GOA:P9WJR9"
/db_xref="InterPro:IPR002820"
/db_xref="InterPro:IPR023045"
/db_xref="InterPro:IPR036522"
/db_xref="UniProtKB/Swiss-Prot:P9WJR9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45921.1"
/translation="MIDHALALTHIDERGAARMVDVSEKPVTLRVAKASGLVIMKPST
LRMISDGAAAKGDVMAAARIAGIAAAKRTGDLIPLCHPLGLDAVSVTITPCEPDRVKI
LATTTTLGRTGVEMEALTAVSVAALTIYDMCKAVDRAMEISQIVLQEKSGGRSGVYRR
SASDLACQSR"
gene 3479700..3479951
/gene="moaD1"
/gene_synonym="moaD"
/locus_tag="Rv3112"
CDS 3479700..3479951
/codon_start=1
/transl_table=11
/gene="moaD1"
/gene_synonym="moaD"
/locus_tag="Rv3112"
/product="Probable molybdenum cofactor biosynthesis
protein D MoaD1 (molybdopterin converting factor small
subunit) (molybdopterin [MPT] converting factor, subunit
1)"
/note="Rv3112, (MTCY164.22), len: 83 aa. Probable
moaD1,molybdenum cofactor biosynthesis protein
(molybdopterin converting factor (subunit 1)), similar to
others e.g. Q9HJF0|TA1019 from Thermoplasma acidophilum
(85 aa), FASTA scores: opt: 144, E(): 0.0012, (31.7%
identity in 82 aa overlap); BAB59710|TVG0556526 from
Thermoplasma volcanium (90 aa), FASTA scores: opt: 144,
E(): 0.0012, (31.7% identity in 82 aa overlap);
P30748|MOAD_ECOLI|CHLA4|CHLM|B0784 from Escherichia coli
strain K12 (81 aa), FASTA scores: opt: 116, E():
0.11,(36.9% identity in 84 aa overlap); etc. N-terminus
also highly similar to to O53375|GPHA|Rv3323c|MTV016.23c
MOAD-MOAE fusion protein from Mycobacterium tuberculosis
(221 aa), FASTA scores: opt: 333, E(): 2e-16, (65.05%
identity in 83 aa overlap); and some similarity with
Rv0868c|MTV043.61c|MOAD2 putative molybdenum cofactor
biosynthesis protein D 2 (92 aa). Note that previously
known as moaD. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3112"
/db_xref="EnsemblGenomes-Tr:CCP45922"
/db_xref="GOA:L7N6B4"
/db_xref="InterPro:IPR003749"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR016155"
/db_xref="UniProtKB/Swiss-Prot:L7N6B4"
/protein_id="CCP45922.1"
/translation="MIKVNVLYFGAVREACDETPREEVEVQNGTDVGNLVDQLQQKYP
RLRDHCQRVQMAVNQFIAPLSTVLGDGDEVAFIPQVAGG"
gene 3480074..3480742
/locus_tag="Rv3113"
CDS 3480074..3480742
/codon_start=1
/transl_table=11
/locus_tag="Rv3113"
/product="Possible phosphatase"
/note="Rv3113, (MTCY164.23), len: 222 aa. Possible
phosphatase, with weak similarity to other phosphatases
e.g. Q9KYY0|SCE33.02c from Streptomyces coelicolor (223
aa), FASTA scores: opt: 368, E(): 1.2e-16, (32.9% identity
in 222 aa overlap); and Q55039|GPH_SYNP7|CBBZ
phosphoglycolate phosphatase from Synechococcus sp. strain
PCC 7942 (Anacystis nidulans R2) (212 aa), FASTA scores:
opt: 176, E(): 0.00025, (24.7% identity in 182 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3113"
/db_xref="EnsemblGenomes-Tr:CCP45923"
/db_xref="GOA:O05790"
/db_xref="InterPro:IPR006439"
/db_xref="InterPro:IPR023198"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="InterPro:IPR041492"
/db_xref="UniProtKB/TrEMBL:O05790"
/protein_id="CCP45923.1"
/translation="MTSRDGFTIVWDWNGTLCDDRTILLDAVGQTLVNEGFEPLSQQQ
LIQRFARPLRTFFENACGRDLLTSEWERVQSTFRRIYRSREAEVTLVEDAYDVLAQGN
RSAAGQFLLSLAPHDELMHFVQKYGIAKWFNGIRGRTRPDQEKPMMLAELIMQRSLNP
TRVVHIGDSLEDAAAASAVGAISVLVTGASLQPPDRVMLKQLQPFVASSLKQALQYAG
GDGD"
gene 3480759..3481289
/locus_tag="Rv3114"
CDS 3480759..3481289
/codon_start=1
/transl_table=11
/locus_tag="Rv3114"
/product="Conserved hypothetical protein"
/note="Rv3114, (MTCY164.24), len: 176 aa. Conserved
hypothetical protein, with some similarity to Q9F9W7
cytosine deaminase from Bifidobacterium longum (143
aa),FASTA scores: opt: 207, E(): 2.2e-07, (37.05% identity
in 108 aa overlap); and Q9RV23|DR1207 cell cycle protein
MESJ,putative/cytosine deaminase-related protein from
Deinococcus radiodurans (600 aa), FASTA scores: opt:
212,E(): 3.5e-07, (33.35% identity in 177 aa overlap).
Equivalent to AAK47536|MT3196 cytidine and deoxycytidylate
deaminase family protein from Mycobacterium tuberculosis
strain CDC1551 (187 aa) but shorter 11 aa. This region is
a possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3114"
/db_xref="EnsemblGenomes-Tr:CCP45924"
/db_xref="GOA:O05791"
/db_xref="InterPro:IPR002125"
/db_xref="InterPro:IPR016193"
/db_xref="UniProtKB/TrEMBL:O05791"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45924.1"
/translation="MVAARLPFGWSADSGVTADIIEAAMELAIDTARHATAPFGAALL
DVTTLRAFSGGNTYFESGDRFAHAETNVLRAAMSTLPELSNHVLISTAEPCPMCAAAS
VLSGVRAIIFGTSIETLIQCGWFQIRISASDVVAASTRPTRPSVYSGFLSHKTDLLYR
NSENRRAMNPWTDPSH"
mobile_element 3481399..3482722
/mobile_element_type="insertion sequence:IS1081-6"
/note="IS1081-6, len: 1324 nt. Insertion sequence IS1081.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
repeat_region 3481399..3481413
/note="15 bp inverted repeat at left end of IS1081:
TCGCGTGATCCTTCG. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 3481451..3482698
/locus_tag="Rv3115"
CDS 3481451..3482698
/codon_start=1
/transl_table=11
/locus_tag="Rv3115"
/product="Probable transposase"
/note="Rv3115, (MTCY164.25), len: 415 aa. Probable IS1081
transposase, similar to others. Has transposases, mutator
family, signature (PS01007). Other copies are
MTCY10G2.02c,MTCY441.35, MTCY77.03c. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3115"
/db_xref="EnsemblGenomes-Tr:CCP45925"
/db_xref="GOA:P96354"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/TrEMBL:P96354"
/inference="protein motif:PROSITE:PS01007"
/protein_id="CCP45925.1"
/translation="MTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADAL
CGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERA
LTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGP
YTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRD
LVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRT
LLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIW
SNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRA
RAALTSTEEPAKQQTTNTPALTT"
repeat_region complement(3482708..3482722)
/note="15 bp inverted repeat at right end of IS1081:
TCGCGTGATCCTTCG. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 3482776..3483945
/gene="moeB2"
/gene_synonym="moeB"
/locus_tag="Rv3116"
CDS 3482776..3483945
/codon_start=1
/transl_table=11
/gene="moeB2"
/gene_synonym="moeB"
/locus_tag="Rv3116"
/product="Probable molybdenum cofactor biosynthesis
protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin
synthase sulphurylase)"
/note="Rv3116, (MTCY164.26), len: 389 aa. Probable
moeB2,molybdopterin cofactor biosynthesis protein,
equivalent to Q9CCG8|MOEZ|ML0817 protein probably involved
in molybdopterin biosynthesis from Mycobacterium leprae
(395 aa), FASTA scores: opt: 1433, E(): 8e-80, (57.8%
identity in 384 aa overlap). Very similar to members of
the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 putative
sulfurylase from Streptomyces coelicolor (392 aa), FASTA
scores: opt: 1562, E(): 1.1e-87, (58.15% identity in 380
aa overlap); Q9XC37|PDTORFF MOEB-like protein (putative
sulfurylase) from Pseudomonas stutzeri (Pseudomonas
perfectomarina) (391 aa), FASTA scores: opt: 1311, E():
2.1e-72, (52.4% identity in 395 aa overlap);
O54307|MPT|MOEB MPT-synthase sulfurylase from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(391 aa), FASTA scores: opt: 1238, E(): 5.7e-68, (51.4%
identity in 393 aa overlap); P74344|MOEB|SLL1536
molybdopterin biosynthesis MOEB protein from Synechocystis
sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1212,
E(): 2.2e-66, (46.5% identity in 398 aa overlap); etc.
Also highly similar to O05860|MTCY07D11.20|MOEB1|Rv3206c
putative molybdenum cofactor biosynthesis protein from
Mycobacterium tuberculosis strain H37Rv (392 aa), FASTA
scores: opt: 1445, E(): 1.5e-80, (56.25% identity in 400
aa overlap). Belongs to the HesA /MoeB/ThiF family. Note
that previously known as moeB. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3116"
/db_xref="EnsemblGenomes-Tr:CCP45926"
/db_xref="GOA:L7N674"
/db_xref="InterPro:IPR000594"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR035985"
/db_xref="InterPro:IPR036873"
/db_xref="UniProtKB/TrEMBL:L7N674"
/protein_id="CCP45926.1"
/translation="MTEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARV
LCIGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPKVESAAE
AVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYV
WGSIYRFNGQTSVFWPGRGPCYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTE
VLKLLTGVGTPLVGRLLMYEALDATYHQIRIAKNPDCAICGDAPTITELVDDSVSCAS
TQSVDPELVISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGL
AQLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSSLLVY"
gene 3483974..3484807
/gene="cysA3"
/gene_synonym="sseC3"
/locus_tag="Rv3117"
CDS 3483974..3484807
/codon_start=1
/transl_table=11
/gene="cysA3"
/gene_synonym="sseC3"
/locus_tag="Rv3117"
/product="Probable thiosulfate sulfurtransferase CysA3
(rhodanese-like protein) (thiosulfate cyanide
transsulfurase) (thiosulfate thiotransferase)"
/note="Rv3117, (MTCY164.27, MT3199, O05793), len: 277 aa.
Probable cysA3 (alternate gene name: sseC3), thiosulfate
sulfurtransferase (see Wooff et al., 2002), equivalent to
Q50036|CYSA|CYSA3|ML2198|THTR_MYCLE putative
sulfurtransferase thiosulfate from Mycobacterium leprae
(277 aa). Also highly similar to other putative
thiosulfate sulfurtransferases e.g. P16385|THTR_SACER|CYSA
from Saccharopolyspora erythraea (Streptomyces erythraeus)
(281 aa), FASTA scores: opt: 1442, E(): 1.7e-84, (75.55%
identity in 274 aa overlap); Q9RXT9DR0217|DR0217 from
Deinococcus radiodurans (286 aa), FASTA scores: opt:
1046,E(): 2.6e-59, (53.8% identity in 275 aa overlap);
Q9HMT7|TSSA|VNG2393G from Halobacterium sp. strain NRC-1
(293 aa), FASTA scores: opt: 1030, E(): 2.7e-58, (56.1%
identity in 278 aa overlap); Q9Y8N8|APE2595 from Aeropyrum
pernix (218 aa), FASTA scores: opt: 808, E():
2.7e-44,(53.5% identity in 215 aa overlap); etc. Identical
second copy present as
Rv0815c|AL022004|MTV043.07c|MT0837|O05793|cysA2 (277 aa)
(100.0% identity in 277 aa overlap). Also shows some
similarity to P96888|THT2_MYCTU|SSEA|Rv3283|MT3382|MTCY71.
23 putative thiosulfate sulfurtransferase from
Mycobacterium tuberculosis (297 aa), FASTA scores: opt:
955, E(): 1.6e-53, (50.2% identity in 271 aa overlap); and
Q59570|THT3_MYCTU|SSEB|Rv2291|MT2348|MTCY339.19c putative
thiosulfate sulfurtransferase from Mycobacterium
tuberculosis (284 aa), FASTA scores: E(): 1.4e-14, (26.7%
identity in 292 aa overlap). Contains rhodanese active
site and C-terminal signatures (PS00380, PS00683). Belongs
to the rhodanese family. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3117"
/db_xref="EnsemblGenomes-Tr:CCP45927"
/db_xref="GOA:P9WHF9"
/db_xref="InterPro:IPR001307"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR036873"
/db_xref="PDB:3AAX"
/db_xref="PDB:3AAY"
/db_xref="PDB:3HWI"
/db_xref="UniProtKB/Swiss-Prot:P9WHF9"
/inference="protein motif:PROSITE:PS00380"
/inference="protein motif:PROSITE:PS00683"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45927.1"
/translation="MARCDVLVSADWAESNLHAPKVVFVEVDEDTSAYDRDHIAGAIK
LDWRTDLQDPVKRDFVDAQQFSKLLSERGIANEDTVILYGGNNNWFAAYAYWYFKLYG
HEKVKLLDGGRKKWELDGRPLSSDPVSRPVTSYTASPPDNTIRAFRDEVLAAINVKNL
IDVRSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSRAANEDGTFKSDEELAKLY
ADAGLDNSKETIAYCRIGERSSHTWFVLRELLGHQNVKNYDGSWTEYGSLVGAPIELG
S"
gene 3484809..3485111
/gene="sseC1"
/gene_synonym="sseC"
/locus_tag="Rv3118"
CDS 3484809..3485111
/codon_start=1
/transl_table=11
/gene="sseC1"
/gene_synonym="sseC"
/locus_tag="Rv3118"
/product="Conserved hypothetical protein SseC1"
/note="Rv3118, (MTCY164.28, O05794), len: 100 aa.
SseC1,conserved hypothetical protein, equivalent to
Q9CBC7|ML2199 hypothetical protein from Mycobacterium
leprae (100 aa),FASTA scores: opt: 545, E(): 3.1e-30,
(84.0% identity in 10 aa overlap). Also similar to
hypothetical proteins e.g. Q50035 from Saccharopolyspora
erythraea (Streptomyces erythraeus) (101 aa), FASTA
scores: opt: 345, E(): 9.7e-17,(57.15% identity in 98 aa
overlap); and Q9K4H3|SCD66.02 from Streptomyces coelicolor
(95 aa), FASTA scores: opt: 249, E(): 2.8e-10, (48.5%
identity in 99 aa overlap). Some weak similarity with
Q9ZB84|PCAG protocatechuate 3,4-dioxygenase alpha-subunit
from Pseudomonas marginata (196 aa), FASTA scores: opt:
109, E(): 1.4, (31.3% identity in 83 aa overlap); and
other bacterial proteins. Identical second copy present as
Rv0814c|AL022004|MTV043.06c|SSEC2 from Mycobacterium
tuberculosis (100 aa) (100.0% identity in 100 aa overlap).
Note that previously known as sseC. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3118"
/db_xref="EnsemblGenomes-Tr:CCP45928"
/db_xref="InterPro:IPR008969"
/db_xref="InterPro:IPR010814"
/db_xref="UniProtKB/Swiss-Prot:P0CG96"
/protein_id="CCP45928.1"
/translation="MCSGPKQGLTLPASVDLEKETVITGRVVDGDGQAVGGAFVRLLD
SSDEFTAEVVASATGDFRFFAAPGSWTLRALSAAGNGDAVVQPSGAGIHEVDVKIT"
gene 3485132..3485575
/gene="moaE1"
/gene_synonym="moaE"
/locus_tag="Rv3119"
CDS 3485132..3485575
/codon_start=1
/transl_table=11
/gene="moaE1"
/gene_synonym="moaE"
/locus_tag="Rv3119"
/product="Probable molybdenum cofactor biosynthesis
protein E MoaE1 (molybdopterin converting factor large
subunit) (molybdopterin [MPT] converting factor, subunit
2)"
/note="Rv3119, (MTCY164.29), len: 147 aa. Probable
moaE1,molybdopterin converting factor E (molybdopterin
converting factor (subunit 2)), highly similar to others
e.g. O31705|MOAE from Bacillus subtilis (157 aa), FASTA
scores: opt: 390, E(): 8.6e-19, (43.95% identity in 132 aa
overlap); Q9K8I7|MOAE|BH3019 from Bacillus halodurans (156
aa), FASTA scores: opt: 369, E(): 2e-17, (42.4% identity
in 132 aa overlap); P30749|MOAE_ECOLI|CHLA5|B0785 from
Escherichia coli strain K12 (149 aa), FASTA scores: opt:
312, E(): 1.1e-13, (38.45% identity in 130 aa overlap);
etc. Also highly similar (but shorter 74 aa) to
O53375|GPHA|Rv3323c|MTV016.23c MOAD-MOAE fusion protein
from Mycobacterium tuberculosis (221 aa), FASTA scores:
opt: 733, E(): 3.9e-41, (76.2% identity in 143 aa
overlap); and highly similar to
O53878|MOAE2|Rv0866|MTV043.59 putative molybdopterin
synthase large subunit from Mycobacterium tuberculosis
(141 aa), FASTA scores: opt: 321, E(): 2.6e-14, (40.9%
identity in 132 aa overlap). Note that previously known as
moaE. This region is a possible MT-complex-specific
genomic island (See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3119"
/db_xref="EnsemblGenomes-Tr:CCP45929"
/db_xref="GOA:P9WJR3"
/db_xref="InterPro:IPR003448"
/db_xref="InterPro:IPR036563"
/db_xref="PDB:2WP4"
/db_xref="UniProtKB/Swiss-Prot:P9WJR3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45929.1"
/translation="MANVVAEGAYPYCRLTDQPLSVDEVLAAVSGPEQGGIVIFVGNV
RDHNAGHDVTRLFYEAYPPMVIRTLMSIIGRCEDKAEGVRVAVAHRTGELQIGDAAVV
IGASAPHRAEAFDAARMCIELLKQEVPIWKKEFSSTGAEWVGDRP"
gene 3485572..3486174
/locus_tag="Rv3120"
CDS 3485572..3486174
/codon_start=1
/transl_table=11
/locus_tag="Rv3120"
/product="Conserved hypothetical protein"
/note="Rv3120, (MTCY164.30), len: 200 aa. Conserved
hypothetical protein, with weak similarity to several
hypothetical proteins and many N-methyl transferases e.g.
Q9X9V1|ORF8 putative methyltransferase from Streptomyces
coelicolor A3(2) (208 aa), FASTA scores: opt: 177, E():
0.00011, (34.6% identity in 130 aa overlap);
Q9XA90|SCF43A.25c putative methyltransferase from
Streptomyces coelicolor (215 aa), FASTA scores: opt:
147,E(): 0.011, (31.3% identity in 166 aa overlap);
BAB52127|MLL5735 probable methyltransferase from Rhizobium
loti (Mesorhizobium loti) (247 aa), FASTA scores: opt:
133,E(): 0.11, (29.75% identity in 158 aa overlap). Highly
similar to O53374|Rv3322c|MTV016.22c possible
methyltransferase from Mycobacterium tuberculosis strain
H37Rv (204 aa), FASTA scores: opt: 691, E():
1.1e-38,(57.0% identity in 200 aa overlap). This region is
a possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3120"
/db_xref="EnsemblGenomes-Tr:CCP45930"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:O05796"
/protein_id="CCP45930.1"
/translation="MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQF
GVPEGPVLELACGRSGTALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVH
ADLCSWQSGDGRFALVLCRLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRA
EWCLKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL"
gene 3486509..3487711
/gene="cyp141"
/locus_tag="Rv3121"
CDS 3486509..3487711
/codon_start=1
/transl_table=11
/gene="cyp141"
/locus_tag="Rv3121"
/product="Probable cytochrome P450 141 Cyp141"
/note="Rv3121, (MTCY164.31), len: 400 aa. Probable
cyp141,cytochrome P-450 integral membrane protein, similar
to other cytochrome P450-dependent oxidases e.g.
Q9X5P9|CYP107N1 from Streptomyces lavendulae (410
aa),FASTA scores: opt: 825, E(): 3.1e-42, (33.35% identity
in 393 aa overlap); Q59819|OLEP|CYP107D1 from Streptomyces
antibioticus (407 aa), FASTA scores: opt: 812, E():
1.9e-41, (34.85% identity in 396 aa overlap);
O32460|CYP107M1 from Actinomadura hibisca (411 aa), FASTA
scores: opt: 713, E(): 1.6e-35, (31.05% identity in 396 aa
overlap); P55544|CPXP_RHISN|CYP112A|Y4LD from Rhizobium
sp. strain NGR234 (400 aa), FASTA scores: opt: 688, E():
5.1e-34, (33.0% identity in 406 aa overlap); etc. Also
similar to MTCY339.44c, MTCY369.22, MTCY50.26,
MTCY03C7.11,MTCY339.34c, MTCY339.42, MTCY369.11c. Contains
cytochrome P450 cysteine heme-iron ligand signature
(PS00086). Belongs to the cytochrome P450 family. This
region is a possible MT-complex-specific genomic island
(See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3121"
/db_xref="EnsemblGenomes-Tr:CCP45931"
/db_xref="GOA:P9WPL7"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPL7"
/inference="protein motif:PROSITE:PS00086"
/protein_id="CCP45931.1"
/translation="MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAW
LVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQG
LNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVH
ELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQS
TMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIV
RFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPN
EHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIK
ELLVTWPT"
gene 3488089..3488559
/locus_tag="Rv3122"
CDS 3488089..3488559
/codon_start=1
/transl_table=11
/locus_tag="Rv3122"
/product="Hypothetical protein"
/note="Rv3122, (MTCY164.32), len: 156 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3122"
/db_xref="EnsemblGenomes-Tr:CCP45932"
/db_xref="UniProtKB/TrEMBL:O07033"
/protein_id="CCP45932.1"
/translation="MYSGCWINNQNGETRVGEDSLEDLEQRRARLYDQLAATGDFRRG
SISENYRRCGKPNCVCAQEGHPGHGPRYLWTRTVAGRGTKGRQLSVEEVDKVRAELAN
YHRFAQVSEQIVAVNEAICEARPPNPAATAPPAGTTGHKKGGSATRSRRSSPPR"
gene 3488569..3489063
/locus_tag="Rv3123"
CDS 3488569..3489063
/codon_start=1
/transl_table=11
/locus_tag="Rv3123"
/product="Hypothetical protein"
/note="Rv3123, (MTCY164.33), len: 164 aa. Hypothetical
unknown protein, but N-terminus shares weak similarity
with N-terminal part of O93439|CMESO-1 BHLH transcription
factor from Gallus gallus (Chicken) (287 aa), FASTA
scores: opt: 129, E(): 0.81, (38.75% identity in 80 aa
overlap). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3123"
/db_xref="EnsemblGenomes-Tr:CCP45933"
/db_xref="UniProtKB/TrEMBL:O07034"
/protein_id="CCP45933.1"
/translation="MRSRSVRWDPRCRPGRSGVGDPHCDDPAGLLAAGAAAGRRHRAP
GPAHRLRARALRVVRRLPRQEPRYRAGPGPVAPRLLPLPHLRAWDGAPWIWNLATAIL
PEATPIVDLYHARQHVHDLAGQLAPALGEHHSDWLTARLVDLDSGDIETLVQQPIGQH
TGHT"
gene 3489506..3490375
/gene="moaR1"
/locus_tag="Rv3124"
CDS 3489506..3490375
/codon_start=1
/transl_table=11
/gene="moaR1"
/locus_tag="Rv3124"
/product="Transcriptional regulatory protein MoaR1"
/note="Rv3124, (MTCY164.34), len: 289 aa.
MoaR1,transcriptional regulatory protein, similar to many
Streptomyces and Mycobacterium tuberculosis regulatory
proteins e.g. Q11052|YC67_MYCTU|Rv1267c|MT1305|MTCY50.15
from Mycobacterium tuberculosis strain H37Rv (388
aa),FASTA scores: opt: 963, E(): 2e-56, (55.15% identity
in 252 aa overlap); O53145 from Mycobacterium tuberculosis
(381 aa); P71484|EMBR from Mycobacterium avium (384 aa),
FASTA scores: opt: 859, E(): 1.5e-49, (52.2% identity in
249 aa overlap); Q9XCC3|TYLT from Streptomyces fradiae
(404 aa),FASTA scores: opt: 462, E(): 3.1e-23, (35.05%
identity in 254 aa overlap); Q9XCC4|TYLS from Streptomyces
fradiae (277 aa), FASTA scores: opt: 456, E(): 5.6e-23,
(33.45% identity in 269 aa overlap); etc. Start chosen by
similarity,alternative possible (see AAK47548 from
Mycobacterium tuberculosis strain CDC1551, longer
N-terminus (311 aa)). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3124"
/db_xref="EnsemblGenomes-Tr:CCP45934"
/db_xref="GOA:O05797"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR005158"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR016032"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:O05797"
/protein_id="CCP45934.1"
/translation="MQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQVVAADA
LVQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDRQQCD
LDRFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALTED
ELLVHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDA
YHRLKSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEEL
TESDKDLLPIGLA"
gene complement(3490476..3491651)
/gene="PPE49"
/locus_tag="Rv3125c"
CDS complement(3490476..3491651)
/codon_start=1
/transl_table=11
/gene="PPE49"
/locus_tag="Rv3125c"
/product="PPE family protein PPE49"
/note="Rv3125c, (MTCY164.35c), len: 391 aa. PPE49, Member
of the Mycobacterium tuberculosis PPE family, similar to
other e.g. P95247|Rv2352c|MTCY98.21c (391 aa), FASTA
scores: opt: 1576, E(): 3.8e-72, (62.55% identity in 398
aa overlap), MTCY98.0029c, MTCY03A2.22c,
MTCY10G2.10,MTCY02B10.25c, MTCI364.08, M TCY21C12.09c,
MTCY48.17. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3125c"
/db_xref="EnsemblGenomes-Tr:CCP45935"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHY5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45935.1"
/translation="MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWASA
SSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQARAAATAFEAA
LAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDYLEMWAQDVAAMVGYHAGA
KSVAATLAPFSLPPVSLAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQ
SLVSQLPLQHASMLFLPVRILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAA
IPAFKPLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPV
ALTQAAGAAGGGMPMMLMPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG"
gene complement(3491808..3492122)
/locus_tag="Rv3126c"
CDS complement(3491808..3492122)
/codon_start=1
/transl_table=11
/locus_tag="Rv3126c"
/product="Hypothetical protein"
/note="Rv3126c, (MTCY164.36c), unknown, len: 104 aa.
Hypothetical unknown protein. Shortened version of
MTCY164.36c, avoiding overlap. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3126c"
/db_xref="EnsemblGenomes-Tr:CCP45936"
/db_xref="UniProtKB/Swiss-Prot:P9WL09"
/protein_id="CCP45936.1"
/translation="MVIRFDQIGSLVLSMKSLASLSFQRCLRENSSLVAALDRLDAAV
DELSALSFDALTTPERDRARRDRDHHPWSRSRSQLSPRMAHGAVHQCQWPKAVWAVID
NP"
gene 3492147..3493181
/locus_tag="Rv3127"
CDS 3492147..3493181
/codon_start=1
/transl_table=11
/locus_tag="Rv3127"
/product="Conserved protein"
/note="Rv3127, (MTCY164.37), len: 344 aa. Conserved
protein, highly similar to Mycobacterium tuberculosis
protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores:
opt: 1212, E(): 6e-69, (56.7% identity in 321 aa
overlap),and also similar to P95195|MTCY03A2.27c (332 aa),
FASTA scores: opt: 521, E(): 1.6e-25; (35.0% identity in
326 aa overlap). Some similarity to C-terminal half of
hypothetical Mycobacterium tuberculosis proteins.
Predicted possible vaccine candidate (See Zvi et al.,
2008)."
/db_xref="EnsemblGenomes-Gn:Rv3127"
/db_xref="EnsemblGenomes-Tr:CCP45937"
/db_xref="GOA:P9WL07"
/db_xref="InterPro:IPR000415"
/db_xref="UniProtKB/Swiss-Prot:P9WL07"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45937.1"
/translation="MLKNAVLLACRAPSVHNSQPWRWVAESGSEHTTVHLFVNRHRTV
PATDHSGRQAIISCGAVLDHLRIAMTAAHWQANITRFPQPNQPDQLATVEFSPIDHVT
AGQRNRAQAILQRRTDRLPFDSPMYWHLFEPALRDAVDKDVAMLDVVSDDQRTRLVVA
SQLSEVLRRDDPYYHAELEWWTSPFVLAHGVPPDTLASDAERLRVDLGRDFPVRSYQN
RRAELADDRSKVLVLSTPSDTRADALRCGEVLSTILLECTMAGMATCTLTHLIESSDS
RDIVRGLTRQRGEPQALIRVGIAPPLAAVPAPTPRRPLDSVLQIRQTPEKGRNASDRN
ARETGWFSPP"
gene complement(3493168..3494181)
/pseudo
/locus_tag="Rv3128c"
CDS complement(3493168..3494181)
/codon_start=1
/transl_table=11
/locus_tag="Rv3128c"
/product="Conserved hypothetical protein"
/note="Rv3128c, (MTCY164.38c), len: 337 aa. Conserved
hypothetical protein, similar to other conserved
hypothetical proteins. This ORF corresponds to a fusion of
MTCY164.38 and MTCY164.39c. Has in-frame amber stop codon
but is similar throughout its length to
Rv2807|MTCY16B7.36c|Z81331 conserved hypothetical protein
from Mycobacterium tuberculosis (384 aa), FASTA scores:
opt: 954, E(): 0, (47.2% identity in 339 aa overlap)."
/experiment="EXISTENCE: identified in proteomics study"
/pseudogene="unknown"
gene 3494660..3494992
/locus_tag="Rv3129"
CDS 3494660..3494992
/codon_start=1
/transl_table=11
/locus_tag="Rv3129"
/product="Conserved hypothetical protein"
/note="Rv3129, (MTCY164.40), len: 110 aa. Conserved
hypothetical protein, with some similarity to various
hypothetical proteins from Streptomyces coelicolor e.g.
Q9RI34|SCJ12.26 hypothetical 14.5 KDA protein (137
aa),FASTA scores: opt: 141, E(): 0.0016, (39.3% identity
in 84 aa overlap); Q9RI49|SCJ12.09c hypothetical 15.8 KDA
protein (146 aa), FASTA scores: opt: 141, E(): 0.0017,
(38.05% identity in 92 aa overlap); Q9RJ05|SCJ1.09C
possible DNA-binding protein (233 aa), FASTA scores: opt:
140, E(): 0.0029, (34.85% identity in 89 aa overlap);
Q9XA48|SCGD3.31c putative branched-chain alpha keto acid
dehydrogenase E1 beta subunit (334 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv3129"
/db_xref="EnsemblGenomes-Tr:CCP45939"
/db_xref="GOA:P9WL05"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR024747"
/db_xref="UniProtKB/Swiss-Prot:P9WL05"
/protein_id="CCP45939.1"
/translation="MVQGRTVLFRTAEGAKLFSAVAKCAVAFEADDHNVAEGWSVIVK
VRAQVLTTDAGVREAERAQLLPWTATLKRHCVRVIPWEITGRHFRFGPEPDRSQTFAC
EASSHNQR"
gene complement(3494975..3496366)
/gene="tgs1"
/locus_tag="Rv3130c"
CDS complement(3494975..3496366)
/codon_start=1
/transl_table=11
/gene="tgs1"
/locus_tag="Rv3130c"
/product="Triacylglycerol synthase (diacylglycerol
acyltransferase) Tgs1"
/note="Rv3130c, (MTCY03A2.28, MTCY164.41c), len: 463 aa.
tgs1, triacylglycerol synthase (See Daniel et al., 2004;
Sirakova et al., 2006), similar to several hypothetical
Mycobacterium tuberculosis strain H37Rv proteins e.g.
O06795|YH60_MYCTU|Rv1760|MTCY28.26 hypothetical 54.1 KDA
protein (502 aa), FASTA scores: opt: 586, E():
9.8e-29,(28.95% identity in 463 aa overlap). Predicted
possible vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3130c"
/db_xref="EnsemblGenomes-Tr:CCP45940"
/db_xref="GOA:P9WKC9"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKC9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45940.1"
/translation="MNHLTTLDAGFLKAEDVDRHVSLAIGALAVIEGPAPDQEAFLSS
LAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWRIALPRPGNEDQLFELIA
DLMARRLDRGRPLWEVWVIEGLADSKWAILTKLHHCMADGIAATHLLAGLSDESMSDS
FASNIHTTMQSQSASVRRGGFRVNPSEALTASTAVMAGIVRAAKGASEIAAGVLSPAA
SSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNVLIQRGERPR
FDSLRTLVPVSTRSNSALSKTDNRVSLMLPNLPVDQENPLQRLRIVHSRLTRAKAGGQ
RQFGNTLMAIANRLPFPMTAWAVGLLMRLPQRGVVTVATNVPGPRRPLQIMGRRVLDL
YPVSPIAMQLRTSVAMLSYADDLYFGILADYDVVADAGQLARGIEDAVARLVAISKRR
KVTRRRGALSLVV"
gene 3496551..3497549
/locus_tag="Rv3131"
CDS 3496551..3497549
/codon_start=1
/transl_table=11
/locus_tag="Rv3131"
/product="Conserved protein"
/note="Rv3131, (MTCY03A2.27c), len: 332 aa. Conserved
protein, similar to other hypothetical bacterial proteins
e.g. O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt:
568, E(): 2.5e-27, (36.7% identity in 321 aa overlap);
O05800|Rv3127|MTCY164.37 (344 aa), FASTA scores: opt:
521,E(): 1.9e-24, (34.95% identity in 326 aa overlap);
Q9RI33|SCJ12.27c from Streptomyces coelicolor (335
aa),FASTA scores: opt: 441, E(): 1.3e-19, (35.75% identity
in 319 aa overlap); Q9RI44|SCJ12.14 from Streptomyces
coelicolor (309 aa), FASTA scores: opt: 328, E():
9.3e-13,(27.9% identity in 308 aa overlap); Q9CBP5|ML1751
from Mycobacterium leprae (721 aa), FASTA scores: opt:
137, E(): 0.78, (26.15% identity in 298 aa overlap); etc.
Equivalent to AAK47555 from Mycobacterium tuberculosis
strain CDC1551 but shorter 12 aa. Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3131"
/db_xref="EnsemblGenomes-Tr:CCP45941"
/db_xref="GOA:P9WIZ7"
/db_xref="InterPro:IPR000415"
/db_xref="UniProtKB/Swiss-Prot:P9WIZ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45941.1"
/translation="MNTHFPDAETVRTVLTLAVRAPSIHNTQPWRWRVCPTSLELFSR
PDMQLRSTDPDGRELILSCGVALHHCVVALASLGWQAKVNRFPDPKDRCHLATIGVQP
LVPDQADVALAAAIPRRRTDRRAYSCWPVPGGDIALMAARAARGGVMLRQVSALDRMK
AIVAQAVLDHVTDEEYLRELTIWSGRYGSVAGVPARNEPPSDPSAPIPGRLFAGPGLS
QPSDVLPADDGAAILALGTETDDRLARLRAGEAASIVLLTATAMGLACCPITEPLEIA
KTRDAVRAEVFGAGGYPQMLLRVGWAPINADPLPPTPRRELSQVVEWPEELLRQRC"
gene complement(3497529..3499265)
/gene="devS"
/gene_synonym="dosS"
/locus_tag="Rv3132c"
CDS complement(3497529..3499265)
/codon_start=1
/transl_table=11
/gene="devS"
/gene_synonym="dosS"
/locus_tag="Rv3132c"
/product="Two component sensor histidine kinase DevS"
/note="Rv3132c, (MTCY03A2.26), len: 578 aa. DevS
(alternate gene name: dosS), membrane-bound two component
sensor histidine kinase (see citations below; dev for
Differentially Expressed in Virulent strain), similar to
others two component sensors e.g. Q9RI43|SCJ12.15c
putative two-component sensor from Streptomyces coelicolor
(585 aa),FASTA scores: opt: 1305, E(): 2.5e-69, (41.35%
identity in 573 aa overlap); Q9ZBY4|SCD78.15 putative two
component sensor from Streptomyces coelicolor (560 aa),
FASTA scores: opt: 1194, E(): 8.1e-63, (41.05% identity in
558 aa overlap); O85371|CPRS two component regulator from
Rhodococcus sp (563 aa), FASTA scores: opt: 803, E():
8.3e-40, (38.4% identity in 552 aa overlap);
Q9L094|SCC24.23 putative two-component sensor histidine
kinase from Streptomyces coelicolor (similarity only in
C-terminus for this one); etc. Also highly similar to
mycobacterium O53473|Rv2027c|MTV018.14c putative membrane
protein (573 aa), FASTA scores: opt: 2333, E():
7.6e-130,(61.45% identity in 576 aa overlap). Predicted
possible vaccine candidate (See Zvi et al., 2008).
Contains GAF domain that binds heme."
/db_xref="EnsemblGenomes-Gn:Rv3132c"
/db_xref="EnsemblGenomes-Tr:CCP45942"
/db_xref="GOA:P9WGK3"
/db_xref="InterPro:IPR003018"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR011712"
/db_xref="InterPro:IPR029016"
/db_xref="InterPro:IPR036890"
/db_xref="PDB:2W3D"
/db_xref="PDB:2W3E"
/db_xref="PDB:2W3F"
/db_xref="PDB:2W3G"
/db_xref="PDB:2W3H"
/db_xref="PDB:2Y79"
/db_xref="PDB:2Y8H"
/db_xref="PDB:3ZXO"
/db_xref="PDB:4YNR"
/db_xref="PDB:4YOF"
/db_xref="UniProtKB/Swiss-Prot:P9WGK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45942.1"
/translation="MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEG
RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEG
IDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPV
RVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEA
TRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETV
GSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGT
VAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIAR
DLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGAS
QGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVVREAVSNAVRHA
KASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLASVPGAS
GTVLRWSAPLSQ"
gene complement(3499262..3499915)
/gene="devR"
/gene_synonym="dosR"
/locus_tag="Rv3133c"
CDS complement(3499262..3499915)
/codon_start=1
/transl_table=11
/gene="devR"
/gene_synonym="dosR"
/locus_tag="Rv3133c"
/product="Two component transcriptional regulatory protein
DevR (probably LuxR/UhpA-family)"
/note="Rv3133c, (MTCY03A2.25), len: 217 aa. DevR
(alternate gene name: dosR), two component transcriptional
regulator (see Dasgupta et al., 2000; dev for
Differentially Expressed in Virulent strain), highly
similar to several e.g. O85372|CPRR two component
regulator from Rhodococcus sp. (212 aa), FASTA scores:
opt: 868, E(): 6.2e-46, (65.05% identity in 206 aa
overlap); Q9RI42|SCJ12.16c putative LuxR family
two-component response regulator from Streptomyces
coelicolor (233 aa), FASTA scores: opt: 849, E():
9.7e-45,(60.55% identity in 218 aa overlap);
Q9XA59|SCGD3.19 putative two-component system response
transcriptional regulator from Streptomyces coelicolor
(218 aa), FASTA scores: opt: 835, E(): 6.5e-44, (61.55%
identity in 208 aa overlap); and similar to others.
Contains bacterial regulatory proteins, LuxR family
signature (PS00622) near C-terminus as seen in bvgA, comA,
dctR, degU, evgA, fimZ,fixJ, gacA, glpR, narL, narP, nodW,
rcsB and uhpA. Helix-turn-helix motif at 166-187 (+3.15
SD). Belongs to the LuxR/UhpA family of transcriptional
regulators. The N-terminal region is similar to that of
other regulatory components of sensory transduction
systems."
/db_xref="EnsemblGenomes-Gn:Rv3133c"
/db_xref="EnsemblGenomes-Tr:CCP45943"
/db_xref="GOA:P9WMF9"
/db_xref="InterPro:IPR000792"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR016032"
/db_xref="PDB:1ZLJ"
/db_xref="PDB:1ZLK"
/db_xref="PDB:3C3W"
/db_xref="PDB:3C57"
/db_xref="UniProtKB/Swiss-Prot:P9WMF9"
/inference="protein motif:PROSITE:PS00622"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45943.1"
/translation="MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVP
AARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYV
VKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGL
LSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP"
gene complement(3499943..3500749)
/locus_tag="Rv3134c"
CDS complement(3499943..3500749)
/codon_start=1
/transl_table=11
/locus_tag="Rv3134c"
/product="Universal stress protein family protein"
/note="Rv3134c, (MTCY03A2.240, len: 268 aa. Universal
stress protein family protein. Ala-, Val- rich (see
citations below), related to other hypothetical
Mycobacterium tuberculosis proteins e.g.
O53474|Rv2028c|MTV018.15c (279 aa), FASTA scores: opt:
562,E(): 3.2e-28, (40.65% identity in 273 aa overlap);
O06188|Rv2624c|MTCY01A10.08 (272 aa), FASTA scores: opt:
458, E(): 1.1e-21, (36.55% identity in 271 aa overlap);
O53472|R2026c|MTV018.13c (294 aa), FASTA scores: opt:
232,E(): 1.9e-07, (30.45% identity in 276 aa overlap);
etc. Shares some similarity with other hypothetical
proteins from Streptomyces coelicolor e.g. Q9RIZ8|SCJ1.16c
(294 aa),FASTA scores: opt: 207, E(): 6.9e-06, (28.9%
identity in 263 aa overlap); Q9K4L5|SC5F8.09 putative
stress-inducible protein (312 aa), FASTA scores: opt: 204,
E(): 1.1e-05,(28.4% identity in 271 aa overlap); etc.
Equivalent to AAK47558|MT3220 Universal stress protein
family from Mycobacterium tuberculosis strain CDC1551 (268
aa). Rv3134c seems cotranscribed with devR-devS (see
Sherman et al.,2001)."
/db_xref="EnsemblGenomes-Gn:Rv3134c"
/db_xref="EnsemblGenomes-Tr:CCP45944"
/db_xref="GOA:P9WFD3"
/db_xref="InterPro:IPR006015"
/db_xref="InterPro:IPR006016"
/db_xref="UniProtKB/Swiss-Prot:P9WFD3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45944.1"
/translation="MSDPRPARAVVVGIDGSRAATHAALWAVDEAVNRDIPLRLVYVI
DPSQLSAAGEGGGQSAARAALHDASRKVEATGQPVKIETEVLCGRPLTKLMQESRSAA
MLCVGSVGLDHVRGRRGSVAATLAGSALCPVAVIHPSPAEPATTSQVSAVVAEVDNGV
VLRHAFEEARLRGVPLRAVAVHAAETPDDVEQGSRLAHVHLSRRLAHWTRLYPEVRVD
RAIAGGSACRHLAANAKPGQLFVADSHSAHELCGAYQPGCAVLTVRSANL"
gene 3501334..3501732
/gene="PPE50"
/locus_tag="Rv3135"
CDS 3501334..3501732
/codon_start=1
/transl_table=11
/gene="PPE50"
/locus_tag="Rv3135"
/product="PPE family protein PPE50"
/note="Rv3135, (MTCY03A2.23c), len: 132 aa. PPE50, Member
of the Mycobacterium tuberculosis Ala-, Gly-rich PPE
family, similar to P95190|Rv3136|MTCY03A2.22c (380
aa),FASTA scores: opt: 494, E(): 6.7e-25, (57.25% identity
in 131 aa overlap) (next ORF downstream),
MTY21C12_9,MTCY3C7_24, MTCI125_27, MTV049_12, MTV049_9,
MTV049_11,MTCY274_24 etc."
/db_xref="EnsemblGenomes-Gn:Rv3135"
/db_xref="EnsemblGenomes-Tr:CCP45945"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:Q6MX07"
/protein_id="CCP45945.1"
/translation="MDYAFLPPEINSARMYSGPGPNSMLVAAASWDALAAELASAAEN
YGSVIARLTGMHWWGPASTSMLAMSAPYVEWLERTAAQTKQTATQARAAAAAFEQAHA
MTVPPALVTGIRGAIVVETASASNTAGTPP"
gene 3501794..3502936
/gene="PPE51"
/locus_tag="Rv3136"
CDS 3501794..3502936
/codon_start=1
/transl_table=11
/gene="PPE51"
/locus_tag="Rv3136"
/product="PPE family protein PPE51"
/note="Rv3136, (MTCY03A2.22c), len: 380 aa. PPE51, Member
of the Mycobacterium tuberculosis Ala-, Gly-rich PPE
family, similar to Q9AGF0|Ov2770c Rv2770c-like protein
from M. microti (397 aa), FASTA scores: opt: 917, E():
9e-41,(46.15% identity in 388 aa overlap);
O33312|Rv2770c|MTV002.35c, MTV002_36,
MTCI125_26,MTCY10G2_10, MTCI364_8, MTV049_28, MTV049_29,
etc."
/db_xref="EnsemblGenomes-Gn:Rv3136"
/db_xref="EnsemblGenomes-Tr:CCP45946"
/db_xref="GOA:P9WHY3"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHY3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45946.1"
/translation="MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAELATTAEA
YGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTAIQARAAALAFEQAYA
MTLPPPVVAANRIQLLALIATNFFGQNTAAIAATEAQYAEMWAQDAAAMYGYATASAA
AALLTPFSPPRQTTNPAGLTAQAAAVSQATDPLSLLIETVTQALQALTIPSFIPEDFT
FLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEVTPGDFGIGELVSA
TSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLT
TLPGTDVAEHGMPGVPGVPVAAGRASGVLPRYGVRLTVMAHPPAAG"
gene complement(3502945..3503277)
/locus_tag="Rv3136A"
CDS complement(3502945..3503277)
/codon_start=1
/transl_table=11
/locus_tag="Rv3136A"
/product="Conserved protein"
/note="Rv3136A, len: 110 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv3136A"
/db_xref="EnsemblGenomes-Tr:CCP45947"
/db_xref="GOA:I6Y2Q7"
/db_xref="UniProtKB/TrEMBL:I6Y2Q7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45947.1"
/translation="MGWEFGVLLILIAVLAVFLAPRLIPRGPRGDLASGTLLVTGVSP
RPDAGGQQYVTIAGIITGPTVNEYAVYQRMAVDVDQWPTVGQILPVVYSPKNPDNWTF
TPNGPPVG"
gene 3503393..3504175
/locus_tag="Rv3137"
CDS 3503393..3504175
/codon_start=1
/transl_table=11
/locus_tag="Rv3137"
/product="Probable monophosphatase"
/note="Rv3137, (MTCY03A2.21c), len: 260 aa. Probable
monophosphatase, equivalent to O32889|MLCB1779_19|ML0662
putative monophosphatase from Mycobacterium leprae (255
aa), FASTA scores: opt: 1403, E(): 1.2e-81, (81.8%
identity in 253 aa overlap). Also similar to
Q9K4B1|SC7E4.05c from Streptomyces coelicolor (266 aa),
FASTA scores: opt: 969,E(): 3.5e-54, (57.9% identity in
259 aa overlap); Q53743|PUR3 mono-phosphatase from
Streptomyces lipmanii (Streptomyces alboniger) (273 aa),
FASTA scores: opt: 862,E(): 2.1e-47, (55.25% identity in
257 aa overlap); BAB50023|MLL3039 mono-phosphatase from
Rhizobium loti (Mesorhizobium loti) (262 aa), FASTA
scores: opt: 448, E(): 3.2e-21, (31.37% identity in 255 aa
overlap); etc. Contains inositol monophosphatase family
signature 1 (PS00629)."
/db_xref="EnsemblGenomes-Gn:Rv3137"
/db_xref="EnsemblGenomes-Tr:CCP45948"
/db_xref="GOA:P95189"
/db_xref="InterPro:IPR000760"
/db_xref="InterPro:IPR011809"
/db_xref="InterPro:IPR020583"
/db_xref="PDB:5YHT"
/db_xref="PDB:5ZON"
/db_xref="UniProtKB/Swiss-Prot:P95189"
/inference="protein motif:PROSITE:PS00629"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45948.1"
/translation="MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDAD
RAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLI
ALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFS
SLSGWARPGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALD
IVVREAGGRLTSLDGVAGPHGGSAVATNGLLHDEVLTRLNAG"
gene 3504195..3505283
/gene="pflA"
/locus_tag="Rv3138"
CDS 3504195..3505283
/codon_start=1
/transl_table=11
/gene="pflA"
/locus_tag="Rv3138"
/product="Probable pyruvate formate lyase activating
protein PflA (formate acetyltransferase activating enzyme)
([pyruvate formate-lyase] activating enzyme)"
/note="Rv3138, (MTCY03A2.20c), len: 362 aa. Probable
pflA,pyruvate formate lyase activating protein, similar to
other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa),
FASTA scores: opt: 926, E(): 1.1e-52, (39.95% identity in
343 aa overlap); O27446|MTH1395 from Methanobacterium
thermoautotrophicum (335 aa), FASTA scores: opt: 909, E():
1.3e-51, (42.2% identity in 327 aa overlap); O28939|AF1330
from Archaeoglobus fulgidus (336 aa), FASTA scores: opt:
884, E(): 5.6e-50, (42.0% identity in 319 aa overlap);
etc. Also similar to O50099|PH1391 hypothetical 40.2 KDA
protein from Pyrococcus horikoshii (348 aa), FASTA scores:
opt: 934, E(): 3.3e-53, (40.5% identity in 343 aa
overlap); and other hypothetical proteins."
/db_xref="EnsemblGenomes-Gn:Rv3138"
/db_xref="EnsemblGenomes-Tr:CCP45949"
/db_xref="GOA:P95188"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR016431"
/db_xref="InterPro:IPR027596"
/db_xref="InterPro:IPR034457"
/db_xref="UniProtKB/TrEMBL:P95188"
/protein_id="CCP45949.1"
/translation="MSDPFTIATKHWHRLHDSRIQCDVCPRACKLHEGQRGLCFVRGR
FDDQVKLTSYGRSSGFCVDPIEKKPLNHFLPGSATLSFGTAGCNLACKFCQNWDISKS
REIDVLASRAAPADIARTAHELGCRSVAFTYNDPTIFWEYAADVADACHDQGIKAVAV
TAGYMCPEPRAEFYRRVDAANVDLKAFTEDFYRKVCVSHLRNVLDTLAYLRHQTNVWL
EITTLLIPGRNDSDAEVAAECRWIRENLGVDVPVHFTAFHPDYKMMDTPATPTATLTR
AREIGIGEGLRFVYTGNVHDAVGGSTSCPGCRATVIVRDWYSIRHYALTEDGRCQACG
YQMPGVYDGPAGHWGQRRLPLLTSLSRM"
gene 3505363..3506769
/gene="fadE24"
/locus_tag="Rv3139"
CDS 3505363..3506769
/codon_start=1
/transl_table=11
/gene="fadE24"
/locus_tag="Rv3139"
/product="Probable acyl-CoA dehydrogenase FadE24"
/note="Rv3139, (MTCY03A2.19c), len: 468 aa. Probable
fadE24, acyl-CoA dehydrogenase (1.3.99.-), equivalent to
O32890|MLCB1779.30|FADE24|ML0661 putative acyl-CoA
dehydrogenase from Mycobacterium leprae (465 aa), FASTA
scores: opt: 2587, E(): 4e-153, (83.6% identity in 464 aa
overlap). Similar to other e.g. Q9HUH0|PA4995 from
Pseudomonas aeruginosa (429 aa), FASTA scores: opt:
1139,E(): 2.8e-63, (45.3% identity in 426 aa overlap);
Q9K6D0|MMGC|BH3799 from Bacillus halodurans (379 aa),
FASTA scores: opt: 603, E(): 4.7e-30, (30.3% identity in
366 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus
halodurans (380 aa), FASTA scores: opt: 601, E(): 6.3e-30,
(32.25% identity in 363 aa overlap); etc. Contains
acyl-CoA dehydrogenases signature 2 (PS00073) near
C-terminus. Belongs to the acyl-CoA dehydrogenases
family."
/db_xref="EnsemblGenomes-Gn:Rv3139"
/db_xref="EnsemblGenomes-Tr:CCP45950"
/db_xref="GOA:P95187"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P95187"
/inference="protein motif:PROSITE:PS00073"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45950.1"
/translation="MTNTTSAANAAKPSGARTDRRGRTTGVGLAPHKRTGIDVALALL
TPIVGQEFLDKYRLRDPLNRSLRYGVKTMFATAGAATRQFQRVQGLRGGPTRLKSSGR
DYFDLTPDDDQKLIIETVDEFAEEVLRPAAHDADDAATYPSDLTAKAAELGITAINIP
EDFDGIAEHRSSVTNVLVAEALAYGDMGLALPILAPGGVASALTHWGSADQQATYLKE
FAGENVPQACVAITEPQPLFDPTRLKTTAVRTPSGYRLDGVKSLIPAAADAELFIVGA
QLGGKPALFIVESAASGLTVKADPSMGIRGAALGQVELCGVSVPLNARLGEDEASDND
YSEALALARLGWAALAVGTSHAVLDYVVPYVKQRQAFGEPIAHRQAVAFMCANIAIEL
DGLRLITWRGASRAEQGLPFAREAALAKRLGSDKGMQIGLDGVQLLGGHGYTKEHPVE
RWYRDLRAIGVAEGVVVI"
gene 3506790..3507995
/gene="fadE23"
/locus_tag="Rv3140"
CDS 3506790..3507995
/codon_start=1
/transl_table=11
/gene="fadE23"
/locus_tag="Rv3140"
/product="Probable acyl-CoA dehydrogenase FadE23"
/note="Rv3140, (MTCY03A2.18c), len: 401 aa. Probable
fadE23, acyl-CoA dehydrogenase (1.3.99.-) (see citation
below), equivalent to O32891|MLCB1779.31|FADE23|ML0660
putative acyl-CoA dehydrogenase from Mycobacterium leprae
(400 aa), FASTA scores: opt: 2307, E(): 3e-136, (89.5%
identity in 401 aa overlap). Also similar to others e.g.
Q9HUH1|PA4994 from Pseudomonas aeruginosa (402 aa), FASTA
scores: opt: 1558, E(): 1.2e-89, (61.0% identity in 400 aa
overlap); O31251 from Acinetobacter sp. ADP1 (401
aa),FASTA scores: opt: 1509, E(): 1.3e-86, (58.2% identity
in 402 aa overlap); Q9K6D1|ACDA or BH3798 from Bacillus
halodurans (380 aa), FASTA scores: opt: 612, E():
8.4e-31,(38.2% identity in 293 aa overlap); Q9AHX9|FADFX
from Pseudomonas putida (375 aa), FASTA scores: opt: 584,
E(): 4.6e-29, (32.7% identity in 379 aa overlap); etc.
Could belong to the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3140"
/db_xref="EnsemblGenomes-Tr:CCP45951"
/db_xref="GOA:P95186"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR036250"
/db_xref="UniProtKB/TrEMBL:P95186"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45951.1"
/translation="MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVEL
DTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSL
PYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVING
EKIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTA
VIRFDNARIPKGNLLGNPEIEVGKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSV
LTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMS
KAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRL
LGLSSSELK"
gene 3508095..3509066
/gene="fadB4"
/locus_tag="Rv3141"
CDS 3508095..3509066
/codon_start=1
/transl_table=11
/gene="fadB4"
/locus_tag="Rv3141"
/product="Probable NADPH quinone oxidoreductase FadB4
(NADPH:quinone reductase) (zeta-crystallin)"
/note="Rv3141, (MTCY03A2.17c), len: 323 aa. Probable
fadB4,quinone oxidoreductase, showing strong similarity to
variety of quinone oxidoreductases and domains in
polyketide and fatty acid synthases e.g. Q9HTV6|PA5234
probable oxidoreductase from Pseudomonas aeruginosa (325
aa), FASTA scores: opt: 737, E(): 1.4e-35, (39.65%
identity in 328 aa overlap); Q9RYQ7|DRA0251 putative NADPH
quinone oxidoreductase from Deinococcus radiodurans (336
aa), FASTA scores: opt: 688, E(): 1e-32, (40.6% identity
in 325 aa overlap); Q9RVG8|DR1061 putative NADPH quinone
oxidoreductase from Deinococcus radiodurans (388 aa),
FASTA scores: opt: 559, E(): 3.3e-25, (36.3% identity in
325 aa overlap); BAB49685|MLL2594 probable quinone
oxidoreductase from Rhizobium loti (Mesorhizobium loti)
(326 aa), FASTA scores: opt: 519, E(): 5.9e-23, (34.25%
identity in 330 aa overlap); Q9LXZ4|T5P19_110 quinone
reductase-like protein from Arabidopsis thaliana (348 aa),
FASTA scores: opt: 517,E(): 8.1e-23, (33.55% identity in
322 aa overlap); etc. Also similar to Q9AA38|CC0770
zinc-containing alcohol dehydrogenase from Caulobacter
crescentus (325 aa), FASTA scores: opt: 673, E(): 7.2e-32,
(40.2% identity in 326 aa overlap); and Q9ABX4|CC0096
zinc-containing alcohol dehydrogenase from Caulobacter
crescentus (332 aa), FASTA scores: opt: 623, E(): 5.7e-29,
(40.7% identity in 334 aa overlap). Also resembles
Mycobacterium tuberculosis proteins
P96826|Rv0149|MTCI5_23, MTCY13D12.11,
MTCY24G1.03,MTCY19H9.01. Belongs to the zinc-containing
alcohol dehydrogenase family, quinone oxidoreductase
subfamily. Thought to be differentially expressed within
host cells (see Triccas et al., 1999)."
/db_xref="EnsemblGenomes-Gn:Rv3141"
/db_xref="EnsemblGenomes-Tr:CCP45952"
/db_xref="GOA:P95185"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P95185"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45952.1"
/translation="MRAVRVTRLEGPDAVEVAEVEEPTSAGVVIEVHAAGVAFPDALL
TRGRYQYRPEPPFVLGAEIAGVVRSAPDNSQVRSGDRVVGLTMLTGGMAEVAVLSPER
VFKLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAGGIGTSTLRLAPA
LGASRTVAVVSTQEKAELATVAGATDVVLAEGFKDAVQELTNGRGVDIVVDPVGGDRF
TDSLRSLAAGGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWSLTHPDALAQQW
SQLERLLRSGKLPPPEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD"
gene complement(3509118..3509546)
/locus_tag="Rv3142c"
CDS complement(3509118..3509546)
/codon_start=1
/transl_table=11
/locus_tag="Rv3142c"
/product="Hypothetical protein"
/note="Rv3142c, (MTCY03A2.16), len: 142 aa. Hypothetical
unknown protein. Equivalent to AAK47569 from Mycobacterium
tuberculosis strain CDC1551 but shorter 33 aa."
/db_xref="EnsemblGenomes-Gn:Rv3142c"
/db_xref="EnsemblGenomes-Tr:CCP45953"
/db_xref="UniProtKB/TrEMBL:P95184"
/protein_id="CCP45953.1"
/translation="MTEQEMTEQWLEGCAVQRIMFRDGLVLNFDDYNELVISVPLQLT
LPAIETSPAEVVAIDPNDPADHERPLFDFAGATCTAFVWYDTGDLHLEFSDGHQIDVH
PDDRVTAWELYGKYHGYAACLAPGKLRVVRHDVADANGDQ"
gene 3509654..3510055
/locus_tag="Rv3143"
CDS 3509654..3510055
/codon_start=1
/transl_table=11
/locus_tag="Rv3143"
/product="Probable response regulator"
/note="Rv3143, (MTCY03A2.15c), len: 133 aa. Probable
response regulator, similar to other sensory transduction
regulatory proteins e.g. Q9X810|SC6G10.25 from
Streptomyces coelicolor (133 aa), FASTA scores: opt: 474,
E(): 2.8e-24,(54.15% identity in 120 aa overlap);
Q9KZ82|SCE25.04c from Streptomyces coelicolor (225 aa),
FASTA scores: opt: 144,E(): 0.016, (32.3% identity in 127
aa overlap); Q9RZT4|DRB0029 from Deinococcus radiodurans
(416 aa), FASTA scores: opt: 145, E(): 0.024, (30.65%
identity in 124 aa overlap). Similar to other regulatory
components of sensory transduction systems."
/db_xref="EnsemblGenomes-Gn:Rv3143"
/db_xref="EnsemblGenomes-Tr:CCP45954"
/db_xref="GOA:P9WGL7"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR011006"
/db_xref="UniProtKB/Swiss-Prot:P9WGL7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45954.1"
/translation="MPDSSTALRILVYSDNVQTRERVMRALGKRLHPDLPDLTYVEVA
TGPMVIRQMDRGGIDLAILDGEATPTGGMGIAKQLKDELASCPPILVLTGRPDDTWLA
SWSRAEAAVPHPVDPIVLGRTVLSLLRAPAH"
gene complement(3510088..3511317)
/gene="PPE52"
/locus_tag="Rv3144c"
CDS complement(3510088..3511317)
/codon_start=1
/transl_table=11
/gene="PPE52"
/locus_tag="Rv3144c"
/product="PPE family protein PPE52"
/note="Rv3144c, (MTCY03A2.14), len: 409 aa. PPE52, Member
of the Mycobacterium tuberculosis PPE family,
Gly-,Ala-rich, similar to others e.g.
P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt:
1007, E(): 5.2e-35, (56.2% identity in 306 aa overlap);
and MTV014_3, MTCY6G11_5,MTCY98.0034c, MTCY31.06c,
MTCY48.17, MTCY98.0029c,MTCY03C7.17c, etc. Nucleotide
position 3510642 in the genome sequence has been
corrected, T:C resulting in S226G."
/db_xref="EnsemblGenomes-Gn:Rv3144c"
/db_xref="EnsemblGenomes-Tr:CCP45955"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:I6X6H8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45955.1"
/translation="MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQS
FASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQA
ATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASA
IAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASG
GGVGYVGGGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFI
GAPLALAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPT
VDPKVAAKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAG
QLRPRVRKDPKIQMRGG"
gene 3511682..3512068
/gene="nuoA"
/locus_tag="Rv3145"
CDS 3511682..3512068
/codon_start=1
/transl_table=11
/gene="nuoA"
/locus_tag="Rv3145"
/product="Probable NADH dehydrogenase I (chain A) NuoA
(NADH-ubiquinone oxidoreductase chain A)"
/note="Rv3145, (MTCY03A2.13c), len: 128 aa. Probable
nuoA,integral membrane NADH dehydrogenase, chain A,
similar to others e.g. Q9XAQ4|NUOA from Streptomyces
coelicolor (119 aa), FASTA scores: opt: 405, E(): 5.4e-20,
(68.75% identity in 128 aa overlap); Q9RU86|DR1506 from
Deinococcus radiodurans (160 aa), FASTA scores: opt: 327,
E(): 9e-15,(40.3% identity in 124 aa overlap);
BAB47039|NDHC from Triticum aestivum (Wheat), FASTA
scores: opt: 273, E(): 2.6e-11, (38.1% identity in 126 aa
overlap); etc. Also similar to a NADH-plastoquinone
oxidoreductases e.g. P26303|NU3C_WHEAT|NDHC from Triticum
aestivum (Wheat) (120 aa), FASTA scores: opt: 273, E():
2.6e-1, (38.1% identity in 126 aa overlap). Belongs to the
complex I subunit 3 family."
/db_xref="EnsemblGenomes-Gn:Rv3145"
/db_xref="EnsemblGenomes-Tr:CCP45956"
/db_xref="GOA:P9WIW7"
/db_xref="InterPro:IPR000440"
/db_xref="InterPro:IPR023043"
/db_xref="InterPro:IPR038430"
/db_xref="UniProtKB/Swiss-Prot:P9WIW7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45956.1"
/translation="MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECG
IEPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFAL
VEMAIFMLTVFVAYAYVWRRGGLTWD"
gene 3512077..3512631
/gene="nuoB"
/locus_tag="Rv3146"
CDS 3512077..3512631
/codon_start=1
/transl_table=11
/gene="nuoB"
/locus_tag="Rv3146"
/product="Probable NADH dehydrogenase I (chain B) NuoB
(NADH-ubiquinone oxidoreductase chain B)"
/note="Rv3146, (MTCY03A2.12c), len: 184 aa. Probable
nuoB,NADH dehydrogenase, chain B, similar to others e.g.
Q9XAQ5|NUOB from Streptomyces coelicolor (184 aa), FASTA
scores: opt: 989, E(): 1.4e-56, (78.25% identity in 184 aa
overlap); Q56218|NQO6_THETH|NQO6 from Thermus aquaticus
(subsp. thermophilus) (181 aa), FASTA scores: opt:
720,E(): 2.6e-39, (64.45% identity in 152 aa overlap);
Q9RU87|DR1505 from Deinococcus radiodurans (181 aa), FASTA
scores: opt: 719, E(): 3e-39, (62.6% identity in 155 aa
overlap); etc. Belongs to the complex I 20 KDA subunit
family. May contain an iron-sulfur 4FE-4S cluster."
/db_xref="EnsemblGenomes-Gn:Rv3146"
/db_xref="EnsemblGenomes-Tr:CCP45957"
/db_xref="GOA:P9WJH1"
/db_xref="InterPro:IPR006137"
/db_xref="InterPro:IPR006138"
/db_xref="UniProtKB/Swiss-Prot:P9WJH1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45957.1"
/translation="MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMA
TAGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGV
CASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQQMPLGINRE
RAIAEAEEAALLARPTIEMRGLLR"
gene 3512628..3513338
/gene="nuoC"
/locus_tag="Rv3147"
CDS 3512628..3513338
/codon_start=1
/transl_table=11
/gene="nuoC"
/locus_tag="Rv3147"
/product="Probable NADH dehydrogenase I (chain C) NuoC
(NADH-ubiquinone oxidoreductase chain C)"
/note="Rv3147, (MTCY03A2.11c), len: 236 aa. Probable
nuoC,NADH dehydrogenase, chain C, similar to others e.g.
Q9XAQ6|NUOC from Streptomyces coelicolor (251 aa), FASTA
scores: opt: 1113, E(): 2.6e-64, (67.35% identity in 236
aa overlap); Q9A6X2|CC1954 from Caulobacter crescentus
(197 aa), FASTA scores: opt: 351, E(): 1.6e-15, (41.65%
identity in 132 aa overlap); BAB48757|MLL1369 from
Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA
scores: opt: 347, E(): 3e-15, (42.4% identity in 132 aa
overlap); etc. Also similar to Q9UUU0|NUGM NUGM protein
precursor from Yarrowia lipolytica (Candida lipolytica)
(281 aa), FASTA scores: opt: 356, E(): 1.1e-15, (34.55%
identity in 162 aa overlap). Also similar to MTCY251.05,
FASTA score: E():4.9e-05. Equivalent to AAK47574 from
Mycobacterium tuberculosis strain CDC1551 but longer 26
aa. Belongs to the complex I 30 KDA subunit family."
/db_xref="EnsemblGenomes-Gn:Rv3147"
/db_xref="EnsemblGenomes-Tr:CCP45958"
/db_xref="GOA:P9WJH3"
/db_xref="InterPro:IPR001268"
/db_xref="InterPro:IPR010218"
/db_xref="InterPro:IPR037232"
/db_xref="UniProtKB/Swiss-Prot:P9WJH3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45958.1"
/translation="MSPPNQDAQEGRPDSPTAEVVDVRRGMFGVSGTGDTSGYGRLVR
QVVLPGSSPRPYGGYFDDIVDRLAEALRHERVEFEDAVEKVVVYRDELTLHVRRDLLP
RVAQRLRDEPELRFELCLGVSGVHYPHETGRELHAVYPLQSITHNRRLRLEVSAPDSD
PHIPSLFAIYPTNDWHERETYDFFGIIFDGHPALTRIEMPDDWQGHPQRKDYPLGGIP
VEYKGAQIPPPDERRGYN"
gene 3513338..3514660
/gene="nuoD"
/locus_tag="Rv3148"
CDS 3513338..3514660
/codon_start=1
/transl_table=11
/gene="nuoD"
/locus_tag="Rv3148"
/product="Probable NADH dehydrogenase I (chain D) NuoD
(NADH-ubiquinone oxidoreductase chain D)"
/note="Rv3148, (MTCY03A2.10c), len: 440 aa. Probable
nuoD,NADH dehydrogenase, chain B, similar to others e.g.
Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa), FASTA
scores: opt: 2198, E(): 1e-131, (73.9% identity in 429 aa
overlap); P15689|NUCM_PARTE from Paramecium tetraurelia
(400 aa), FASTA scores: opt: 922, E(): 5.8e-51, (38.5%
identity in 408 aa overlap); Q9RU89|NUOD_DEIRA|DR1503 from
Deinococcus radiodurans (401 aa), FASTA scores: opt:
922,E(): 5.8e-51, (47.75% identity in 404 aa overlap);
etc. Equivalent to AAK47575 from Mycobacterium
tuberculosis strain CDC1551 but longer 42 aa. Contains
helix-turn-helix motif at aa 340-361. Belongs to the
complex I 49 KDA subunit family."
/db_xref="EnsemblGenomes-Gn:Rv3148"
/db_xref="EnsemblGenomes-Tr:CCP45959"
/db_xref="GOA:P9WJH5"
/db_xref="InterPro:IPR001135"
/db_xref="InterPro:IPR014029"
/db_xref="InterPro:IPR022885"
/db_xref="InterPro:IPR029014"
/db_xref="InterPro:IPR038290"
/db_xref="UniProtKB/Swiss-Prot:P9WJH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45959.1"
/translation="MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMG
PQHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLS
PFFNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTP
MFVGFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLRE
MGELLNENAIWKARTQGVGYLDLTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYE
FDVITDDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGP
DGLGNSPKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDG
GTRPYRVHYRDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR"
gene 3514657..3515415
/gene="nuoE"
/locus_tag="Rv3149"
CDS 3514657..3515415
/codon_start=1
/transl_table=11
/gene="nuoE"
/locus_tag="Rv3149"
/product="Probable NADH dehydrogenase I (chain E) NuoE
(NADH-ubiquinone oxidoreductase chain E)"
/note="Rv3149, (MTCY03A2.09c), len: 252 aa. Probable
nuoE,NADH dehydrogenase, chain E, similar to others e.g.
Q9XAQ8|NUOE from Streptomyces coelicolor (290 aa), FASTA
scores: opt: 1002, E(): 5.7e-55, (69.5% identity in 213 aa
overlap); P40915|NUHM_NEUCR|NUO-24 from Neurospora crassa
(263 aa), FASTA scores: opt: 412, E(): 1.9e-18, (38055%
identity in 192 aa overlap); P19234|NUHM_RAT from Rattus
norvegicus (Rat) (241 aa), FASTA scores: opt: 410, E():
2.4e-18, (23.9% identity in 237 aa overlap); etc. Belongs
to the complex I 24 KDA subunit family. Binds a 2FE-2S
cluster (potential)."
/db_xref="EnsemblGenomes-Gn:Rv3149"
/db_xref="EnsemblGenomes-Tr:CCP45960"
/db_xref="GOA:P9WIV5"
/db_xref="InterPro:IPR002023"
/db_xref="InterPro:IPR036249"
/db_xref="InterPro:IPR041921"
/db_xref="InterPro:IPR042128"
/db_xref="UniProtKB/Swiss-Prot:P9WIV5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45960.1"
/translation="MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDA
KEIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYR
RRPTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACD
YAPVVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQR
PDEGQGGPGAPTLAGLQVARKNDMQAPPTPGADE"
gene 3515412..3516749
/gene="nuoF"
/locus_tag="Rv3150"
CDS 3515412..3516749
/codon_start=1
/transl_table=11
/gene="nuoF"
/locus_tag="Rv3150"
/product="Probable NADH dehydrogenase I (chain F) NuoF
(NADH-ubiquinone oxidoreductase chain F)"
/note="Rv3150, (MTCY03A2.08c), len: 445 aa. Probable
nuoF,NADH dehydrogenase, chain F, similar to others e.g.
Q9XAQ9|NUOF_STRCO from Streptomyces coelicolor (449
aa),FASTA scores: opt: 2314, E(): 3.5e-139, (76.25%
identity in 434 aa overlap); NUF2_RHIME from Rhizobium
meliloti (421 aa), FASTA scores: opt: 1545, E(): 1.8e-90,
(53.1% identity in 424 aa overlap); Q9RU92|DR1500 from
Deinococcus radiodurans (444 aa), FASTA scores: opt: 1445,
E(): 4.1e-84, (52.9% identity in 427 aa overlap); etc.
Contains respiratory-chain NADH dehydrogenase 51 Kd
subunit signature 2 (PS00645). Belongs to the complex I 51
KDA subunit family. Cofactor: FMN and one 4FE-4S cluster
(probable)."
/db_xref="EnsemblGenomes-Gn:Rv3150"
/db_xref="EnsemblGenomes-Tr:CCP45961"
/db_xref="GOA:P9WIV7"
/db_xref="InterPro:IPR001949"
/db_xref="InterPro:IPR011537"
/db_xref="InterPro:IPR011538"
/db_xref="InterPro:IPR019554"
/db_xref="InterPro:IPR019575"
/db_xref="InterPro:IPR037207"
/db_xref="InterPro:IPR037225"
/db_xref="UniProtKB/Swiss-Prot:P9WIV7"
/inference="protein motif:PROSITE:PS00645"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45961.1"
/translation="MTTQATPLTPVISRHWDDPESWTLATYQRHDRYRGYQALQKALT
MPPDDVISIVKDSGLRGRGGAGFATGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTC
KDIPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVVPVLRRLHNAVAEAYAAGFLG
RNIGGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTV
INNVETIASVPSIILGGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLREL
LDYAGGVRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDET
TCVVRAVRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDISDS
ILGKSFCALGDGAASPVMSSIKHFRDEYLAHVEGGGCPFDPRDSMLVANGVDA"
gene 3516746..3519166
/gene="nuoG"
/locus_tag="Rv3151"
CDS 3516746..3519166
/codon_start=1
/transl_table=11
/gene="nuoG"
/locus_tag="Rv3151"
/product="Probable NADH dehydrogenase I (chain G) NuoG
(NADH-ubiquinone oxidoreductase chain G)"
/note="Rv3151, (MTCY03A2.07c), len: 806 aa. Probable
nuoG,NADH dehydrogenase I, chain G, similar to others e.g.
Q9XAR0|NUOG_STRCO from Streptomyces coelicolor (843
aa),FASTA scores: opt: 1968 ,E(): 5.2e-107, (62.45%
identity in 818 aa overlap); P56914|NUG2_RHIME from
Rhizobium meliloti (853 aa), FASTA scores: opt: 964, E():
1.6e-48, (30.6% identity in 840 aa overlap); etc. But also
similarity with other proteins e.g. P77908|FDHA formate
dehydrogenase,alpha subunit (formate dehydrogenase
[NADP+]) from Moorella thermoacetica (Clostridium
thermoaceticum) (893 aa), FASTA scores: opt: 928, E():
2e-46, (28.65% identity in 865 aa overlap); and
Q9UUU3|NUAM NUAM protein precursor from Yarrowia
lipolytica (Candida lipolytica) (728 aa), FASTA scores:
opt: 894, E(): 1.7e-44, (31.95% identity in 676 aa
overlap). Equivalent to AAK47578 from Mycobacterium
tuberculosis strain CDC1551 but longer 15 aa. Contains
respiratory-chain NADH dehydrogenase 75 kDa subunit
signature 2 (PS00642). Belongs to the complex I 75 KDA
subunit family. Cofactor: may bind two 4FE-4S cluster and
one 2FE-2S cluster."
/db_xref="EnsemblGenomes-Gn:Rv3151"
/db_xref="EnsemblGenomes-Tr:CCP45962"
/db_xref="GOA:P9WIV9"
/db_xref="InterPro:IPR000283"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR006656"
/db_xref="InterPro:IPR006657"
/db_xref="InterPro:IPR006963"
/db_xref="InterPro:IPR009010"
/db_xref="InterPro:IPR010228"
/db_xref="InterPro:IPR019574"
/db_xref="InterPro:IPR036010"
/db_xref="UniProtKB/Swiss-Prot:P9WIV9"
/inference="protein motif:PROSITE:PS00642"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45962.1"
/translation="MTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQ
IPRFCDHPLLEPVGACRQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHG
VMELLLINHPLDCPMCDKGGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLD
RERCILCARCTRFSDQIAGDPFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGA
LTGTAYRFRARPFDLVSSPSVCEHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCD
KGRWAFTYATQPDVITTPLIRDGGDPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVG
GRVTWEDAYAYAKFARITLGTNDIDFRARPHSAEEADFLAARIAGRHMAVSYADLESA
PVVLLVGFEPEDESPIVFLRLRKAARRHRVPVYTIAPFATGGLHKMSGRLIKTVPGGE
PAALDDLATGAVGDLLATPGAVIIVGERLATVPGGLSAAARLADTTGARLAWVPRRAG
ERGALEAGALPTLLPGGRPLADEVARAQVCAAWHIAELPAAAGRDADGILAAAADETL
AALLVGGIEPADFADPDAVLAALDATGFVVSLELRHSTVTERADVVFPVAPTTQKAGA
FVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGI
WDGKHAAGPHIAATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSP
DTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGS
IVKIGAGS"
gene 3519282..3520514
/gene="nuoH"
/locus_tag="Rv3152"
CDS 3519282..3520514
/codon_start=1
/transl_table=11
/gene="nuoH"
/locus_tag="Rv3152"
/product="Probable NADH dehydrogenase I (chain H) NuoH
(NADH-ubiquinone oxidoreductase chain H)"
/note="Rv3152, (MTCY03A2.06c), len: 410 aa. Probable
nuoH,integral membrane NADH dehydrogenase I, chain H,
similar to others e.g. Q9XAR1 Q9XAR1|NUOH from
Streptomyces coelicolor (467 aa), FASTA scores: opt: 1630,
E(): 3.4e-90, (58.35% identity in 413 aa overlap);
Q9RU94|DR1498 from Deinococcus radiodurans (397 aa), FASTA
scores: opt: 1081, E(): 2e-57,(45.5% identity in 391 aa
overlap); Q9ZCF7|NUOH_RICPR|RP796 from Rickettsia
prowazekii (339 aa), FASTA scores: opt: 976, E(): 3.4e-51,
(46.2% identity in 329 aa overlap); etc. Contains
respiratory-chain NADH dehydrogenase subunit 1 signature 2
(PS00668). Some similarity to MTCY251.02 (FASTA score:
E(): 1.2e-07). Belongs to the complex I subunit 1 family."
/db_xref="EnsemblGenomes-Gn:Rv3152"
/db_xref="EnsemblGenomes-Tr:CCP45963"
/db_xref="GOA:P9WIX1"
/db_xref="InterPro:IPR001694"
/db_xref="InterPro:IPR018086"
/db_xref="UniProtKB/Swiss-Prot:P9WIX1"
/inference="protein motif:PROSITE:PS00668"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45963.1"
/translation="MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLR
PGPNRVGPKGALQSLADGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFG
PEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQV
ISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAP
FDLPEAEGELVAGFHTEYSSLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMW
ASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVA
AIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEP
AFPTPPLLAGATKENAGG"
gene 3520507..3521142
/gene="nuoI"
/locus_tag="Rv3153"
CDS 3520507..3521142
/codon_start=1
/transl_table=11
/gene="nuoI"
/locus_tag="Rv3153"
/product="Probable NADH dehydrogenase I (chain I) NuoI
(NADH-ubiquinone oxidoreductase chain I)"
/note="Rv3153, (MTCY03A2.05c), len: 211 aa. Probable
nuoI,NADH dehydrogenase I, chain I, similar to others e.g.
Q9XAR2|NUOI from Streptomyces coelicolor (211 aa), FASTA
scores: opt: 825, E(): 9.3e-44, (70.1% identity in 164 aa
overlap); Q56224|NQO9_THETH from Thermus aquaticus (subsp.
thermophilus) (182 aa), FASTA scores: opt: 543, E():
1.8e-26, (50.9% identity in 163 aa overlap); Q9RU95|DR1497
from Deinococcus radiodurans (178 aa), FASTA scores: opt:
527, E(): 1.7e-25, (48.75% identity in 162 aa overlap);
etc. Contains two 4Fe-4S ferredoxins, iron-sulfur binding
region signatures (PS00198). Belongs to the complex I 23
KDA subunit family. The iron-sulfur centers are similar to
those of 'bacterial-type' 4FE-4S ferredoxins. Cofactor:
binds two 4FE-4S clusters."
/db_xref="EnsemblGenomes-Gn:Rv3153"
/db_xref="EnsemblGenomes-Tr:CCP45964"
/db_xref="GOA:P9WJG9"
/db_xref="InterPro:IPR010226"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR017900"
/db_xref="UniProtKB/Swiss-Prot:P9WJG9"
/inference="protein motif:PROSITE:PS00198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45964.1"
/translation="MANTDRPALPHKRAVPPSRADSGPRRRRTKLLDAVAGFGVTLGS
MFKKTVTEEYPERPGPVAARYHGRHQLNRYPDGLEKCIGCELCAWACPADAIYVEGAD
NTEEERFSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTYDYELADDNRADLIYE
KDRLLAPLLPEMAAPPHPRTPGATDKDYYLGNVTAEGLRGVRESQTTGDSR"
gene 3521139..3521927
/gene="nuoJ"
/locus_tag="Rv3154"
CDS 3521139..3521927
/codon_start=1
/transl_table=11
/gene="nuoJ"
/locus_tag="Rv3154"
/product="Probable NADH dehydrogenase I (chain J) NuoJ
(NADH-ubiquinone oxidoreductase chain J)"
/note="Rv3154, (MTCY03A2.04c), len: 262 aa. Probable
nuoJ,transmembrane NADH dehydrogenase I, chain J, similar
to others e.g. Q9XAR3|NUOJ from Streptomyces coelicolor
(285 aa), FASTA scores: opt: 991, E(): 3.2e-52, (63.7%
identity in 243 aa overlap); Q9JX90|NUOJ|NMA0006 from
Neisseria meningitidis (serogroup A) (223 aa), FASTA
scores: opt: 329, E(): 9.6e-13, (34.85% identity in 175 aa
overlap); Q9K1B2|NMB0253 from Neisseria meningitidis
(serogroup B) (223 aa), FASTA scores: opt: 326, E():
1.5e-12, (34.85% identity in 175 aa overlap); etc. But
also similarity with Q00243|NU6C_PLEBO|NDH6
NADH-plastoquinone oxidoreductase chain 6 homolog
(catalytic activity: NADH + plastoquinone = NAD(+) +
plastoquinol) from Plectonema boryanum (199 aa),FASTA
scores: opt: 287, E(): 2.8e-10, (34.35% identity in 195 aa
overlap). Similar to polypeptide 6 of the NADH-ubiquinol
oxidoreductase of chloroplasts or mitochondria."
/db_xref="EnsemblGenomes-Gn:Rv3154"
/db_xref="EnsemblGenomes-Tr:CCP45965"
/db_xref="GOA:P95172"
/db_xref="InterPro:IPR001457"
/db_xref="InterPro:IPR042106"
/db_xref="UniProtKB/TrEMBL:P95172"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45965.1"
/translation="MTAVLASDVIVRTSTGEAVMFWVLSALALLGAVGVVLAVNAVYS
AMFLAMTMIILAVFYMAQDALFLGVVQVVVYTGAVMMLFLFVLMLIGVDSAESLKETL
RGQRVAAVLTGVGFGVLLISTIGQVATRGFAGLTVANANGNVEGLAALIFSRYLWAFE
LTSALLITAAVGAMVLAHRERFERRKTQRELSQERFRPGGHPTPLPNPGVYARHNAVD
VAALLPDGSYSELSVPRMLRTRGADGLQTPSPGAVSGSLEGGAS"
gene 3521924..3522223
/gene="nuoK"
/locus_tag="Rv3155"
CDS 3521924..3522223
/codon_start=1
/transl_table=11
/gene="nuoK"
/locus_tag="Rv3155"
/product="Probable NADH dehydrogenase I (chain K) NuoK
(NADH-ubiquinone oxidoreductase chain K)"
/note="Rv3155, (MTCY03A2.03c), len: 99 aa. Probable
nuoK,integral membrane NADH dehydrogenase I, chain K,
similar to others e.g. Q9XAR4|NUOK from Streptomyces
coelicolor (99 aa), FASTA scores: opt: 509, E(): 2.7e-31,
(78.55% identity in 98 aa overlap);
Q56226|NQOB_THETH|NQO11 from Thermus aquaticus (subsp.
thermophilus) (95 aa), blast scores: initn: 298, init1:
180, bits: 85.7, FASTA scores: opt: 313,E(): 9.4e-17,
(53.7% identity in 95 aa overlap); Q9RU97|DR1495 from
Deinococcus radiodurans (103 aa), FASTA scores: opt: 309,
E(): 2e-16, (52.0% identity in 100 aa overlap); etc. But
also similarity with NADH-plastoquinone oxidoreductases
chain 4L e.g. Q9MUL4|NULC_MESVI|NDHE from Mesostigma
viride (catalytic activity: NADH + plastoquinone = NAD(+)
+ plastoquinol) (101 aa), FASTA scores: opt: 280,E():
2.8e-14, (40.6% identity in 101 aa overlap); and
P06261|NULC_TOBAC|NDHE|NDH4L from Nicotiana tabacum
(Common tobacco) (101 aa), FASTA scores: opt: 259, E():
1e-12,(43.0% identity in 93 aa overlap). Similar to
polypeptide 4L of the NADH-ubiquinol oxidoreductase of
chloroplasts or mitochondria."
/db_xref="EnsemblGenomes-Gn:Rv3155"
/db_xref="EnsemblGenomes-Tr:CCP45966"
/db_xref="GOA:P9WIX3"
/db_xref="InterPro:IPR001133"
/db_xref="InterPro:IPR039428"
/db_xref="UniProtKB/Swiss-Prot:P9WIX3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45966.1"
/translation="MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLA
FVTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG"
gene 3522234..3524135
/gene="nuoL"
/locus_tag="Rv3156"
CDS 3522234..3524135
/codon_start=1
/transl_table=11
/gene="nuoL"
/locus_tag="Rv3156"
/product="Probable NADH dehydrogenase I (chain L) NuoL
(NADH-ubiquinone oxidoreductase chain L)"
/note="Rv3156, (MTCY03A2.02c), len: 633 aa. Probable
nuoL,integral membrane NADH dehydrogenase I, chain L,
similar to others e.g. Q9XAR5|NUOL_STRCO from Streptomyces
coelicolor (654 aa), FASTA scores: opt: 2074, E():
1.1e-111, (61.1% identity in 648 aa overlap);
Q56227|NQOC_THETH|NQO12 from Thermus aquaticus (subsp.
thermophilus) (606 aa), FASTA scores: opt: 1420, E():
3.8e-74, (43.35% identity in 630 aa overlap);
Q9ZJV6|NUOL|JHP1192 from Helicobacter pylori J99
(Campylobacter pylori J99) (612 aa), FASTA scores: opt:
1279, E(): 4.7e-66, (41.65% identity in 516 aa overlap);
etc. Also similar to MTCY251.04 (FASTA score: E():
1.3e-11) and MTCY03A2.01c (FASTA score: E(): 2.3e-10).
Similar to polypeptide 5 of the NADH-ubiquinol
oxidoreductase of chloroplasts or mitochondrial."
/db_xref="EnsemblGenomes-Gn:Rv3156"
/db_xref="EnsemblGenomes-Tr:CCP45967"
/db_xref="GOA:P9WIW1"
/db_xref="InterPro:IPR001516"
/db_xref="InterPro:IPR001750"
/db_xref="InterPro:IPR003945"
/db_xref="InterPro:IPR018393"
/db_xref="UniProtKB/Swiss-Prot:P9WIW1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45967.1"
/translation="MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAAL
AAFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGV
GSLIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLL
IGFWYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAV
LTAIGLLMLLGACAKSAQVPLQAWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPL
YNLAPTAQLAVVIVGAVTLLFGAIIGCAKDDIKRALAASTISQIGYMVLAAGLGPAGY
AFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAI
IGVPPFAGFFSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKR
WTPGAHPHEAPAVMTWPMILLAVGSVFSGGLLAVGGTLRHWLQPVVGSHEEATHALPT
WVATTLALGVVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFNEEVFMR
PGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVA
AALLVVQLW"
gene 3524132..3525793
/gene="nuoM"
/locus_tag="Rv3157"
CDS 3524132..3525793
/codon_start=1
/transl_table=11
/gene="nuoM"
/locus_tag="Rv3157"
/product="Probable NADH dehydrogenase I (chain M) NUOK
(NADH-ubiquinone oxidoreductase chain M)"
/note="Rv3157, (MTCY03A2.01c-MTV014.01c), len: 553 aa.
Probable nuoM, integral membrane NADH dehydrogenase
I,chain M, similar to others e.g. Q9XAR6|NUOM from
Streptomyces coelicolor (523 aa), FASTA scores: opt:
1621,E(): 4.2e-89, (56.55% identity in 541 aa overlap);
P50974|NUOM_RHOCA|NUOM from Rhodobacter capsulatus
(Rhodopseudomonas capsulata) (512 aa), FASTA scores: opt:
996, E(): 6.5e-52, (38.2% identity in 521 aa overlap);
P29925|NQOD_PARDE|NQO13 from Paracoccus denitrificans (513
aa), FASTA scores: opt: 987, E(): 2.2e-51, (37.05%
identity in 540 aa overlap); etc. Also similar to
MTCY251.04 (FASTA score: E(): 3.3e-16) and MTCY03A2.02c
(FASTA score: E(): 9.6e-13). Similar to polypeptide 4 of
the NADH-ubiquinol oxidoreductase of chloroplasts or
mitochondrial."
/db_xref="EnsemblGenomes-Gn:Rv3157"
/db_xref="EnsemblGenomes-Tr:CCP45968"
/db_xref="GOA:P9WIW5"
/db_xref="InterPro:IPR001750"
/db_xref="InterPro:IPR003918"
/db_xref="InterPro:IPR010227"
/db_xref="UniProtKB/Swiss-Prot:P9WIW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45968.1"
/translation="MNNVPWLSVLWLVPLAGAVLIILLPPGRRRLAKWAGMVVSVLTL
AVSIVVAAEFKPSAEPYQFVEKHSWIPAFGAGYTLGVDGIAVVLVLLTTVLIPLLLVA
GWNDATDADDLSPASGRYPQRPAPPRLRSSGGERTRGVHAYVALTLAIESMVLMSVIA
LDVLLFYVFFEAMLIPMYFLIGGFGQGAGRSRAAVKFLLYNLFGGLIMLAAVIGLYVV
TAQYDSGTFDFREIVAGVAAGRYGADPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAA
VESTPATAVLMMAVMDKVGTFGMLRYCLQLFPDPSTYFRPLIVTLAIIGVIYGAIVAI
GQTDMMRLIAYTSISHFGFIIAGIFVMTTQGQSGSTLYMLNHGLSTAAVFLIAGFLIA
RRGSRSIADYGGVQKVAPILAGTFMVSAMATVSLPGLAPFISEFLVLLGTFSRYWLAA
AFGVTALVLSAVYMLWLYQRVMTGPVAEGNERIGDLVGREMIVVAPLIALLLVLGVYP
KPVLDIINPAVENTMTTIGQHDPAPSVAHPVPAVGASRTAEGPHP"
gene 3525790..3527385
/gene="nuoN"
/locus_tag="Rv3158"
CDS 3525790..3527385
/codon_start=1
/transl_table=11
/gene="nuoN"
/locus_tag="Rv3158"
/product="Probable NADH dehydrogenase I (chain N) NuoN
(NADH-ubiquinone oxidoreductase chain N)"
/note="Rv3158, (MTV014.02c), len: 531 aa. Probable
nuoN,integral membrane NADH dehydrogenase I, chain N,
similar to others e.g. Q9XAR7|SC10A7.08c from Streptomyces
coelicolor (552 aa), FASTA scores: opt: 1493, E():
1.1e-81, (56.7% identity in 543 aa overlap); Q9PGI2|XF0318
from Xylella fastidiosa (485 aa), FASTA scores: opt: 942,
E(): 7.4e-49,(39.6% identity in 379 aa overlap);
CAB51628|NUON2 from Rhizobium meliloti (Sinorhizobium
meliloti) (479 aa), FASTA scores: opt: 934, E(): 2.2e-48,
(35.5% identity in 479 aa overlap); etc. But also
similarity with NADH-plastoquinone oxidoreductases chain
4L (catalytic activity: NADH + plastoquinone = NAD(+) +
plastoquinol) e.g. P29801|NU2C_SYNP7|NDHB from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(521 aa), FASTA scores: opt: 921, E(): 1.4e-47, (40.25%
identity in 395 aa overlap). Belongs to the complex I
subunit 2 family."
/db_xref="EnsemblGenomes-Gn:Rv3158"
/db_xref="EnsemblGenomes-Tr:CCP45969"
/db_xref="GOA:P9WIW9"
/db_xref="InterPro:IPR001750"
/db_xref="InterPro:IPR010096"
/db_xref="UniProtKB/Swiss-Prot:P9WIW9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45969.1"
/translation="MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVT
LALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAE
RSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSV
GGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFF
LYGVALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPD
VYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVT
AVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLV
RGADGSAGSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAA
SAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEESGDTPHVAAPGVLSKAAIAVCTVV
TVVLGIAPQPVLDLADQAAQLLR"
gene complement(3527391..3529163)
/gene="PPE53"
/locus_tag="Rv3159c"
CDS complement(3527391..3529163)
/codon_start=1
/transl_table=11
/gene="PPE53"
/locus_tag="Rv3159c"
/product="PPE family protein PPE53"
/note="Rv3159c, (MTV014.03c), len: 590 aa. PPE53, Member
of the Mycobacterium tuberculosis PPE_family of Gly-,
Asn-rich proteins. Highly similar to
P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt:
2289, E(): 3.2e-98, (63.5% identity in 600 aa overlap);
and also similar to MTCY48_17,MTV041_29, MTCY6G11_5,
MTCY98_24, etc. Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3159c"
/db_xref="EnsemblGenomes-Tr:CCP45970"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q6MX04"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45970.1"
/translation="MNYSVLPPEINSLRMFTGAGSAPMLAASVAWDRLAAELAVAASS
FGSVTSGLAGQSWQGAAAAAMAAAAAPYAGWLAAAAARAAGASAQAKAVASAFEAARA
ATVHPMLVAANRNAFVQLVLSNLFGQNAPAIAAAEAMYEQMWAADVAAMVGYHGGASA
AAAQLSSWSIGLQQALPAAPSALAAAIGLGNIGVGNLGGGNTGDYNLGSGNSGNANVG
SGNSGNANVGSGNDGATNLGSGNIGNTNLGSGNVGNVNLGSGNRGFGNLGNGNFGSGN
LGSGNTGSTNFGGGNLGSFNLGSGNIGSSNIGFGNNGDNNLGLGNNGNNNIGFGLTGD
NLVGIGALNSGIGNLGFGNSGNNNIGFFNSGNNNVGFFNSGNNNFGFGNAGDINTGFG
NAGDTNTGFGNAGFFNMGIGNAGNEDMGVGNGGSFNVGVGNAGNQSVGFGNAGTLNVG
FANAGSINTGFANSGSINTGGFDSGDRNTGFGSSVDQSVSSSGFGNTGMNSSGFFNTG
NVSAGYGNNGDVQSGINNTNSGGFNVGFYNSGAGTVGIANSGLQTTGIANSGTLNTGV
ANTGDHSSGGFNQGSDQSGFFGQP"
gene complement(3529338..3529979)
/locus_tag="Rv3160c"
CDS complement(3529338..3529979)
/codon_start=1
/transl_table=11
/locus_tag="Rv3160c"
/product="Possible transcriptional regulatory protein
(probably TetR-family)"
/note="Rv3160c, (MTV014.04c), len: 213 aa. Possible
transcriptional regulator, with some similarity to others
e.g. Q9S3L4|AMTR AMTR protein (global repressor in the
nitrogen regulation system; see Jakoby et al., 2000) (222
aa), FASTA scores: opt: 182, E(): 7.3e-05, (27.9% identity
in 208 aa overlap); Q9X7X9|SC6A5.33c putative regulatory
protein from Streptomyces coelicolor (223 aa), FASTA
scores: opt: 176, E(): 0.00018, (26.5% identity in 185 aa
overlap); Q9XA31|SCH69.03c putative transcriptional
regulator from Streptomyces coelicolor (209 aa), FASTA
scores: opt: 173, E(): 0.00027, (27.25% identity in 176 aa
overlap); BAB54133|MLL7734 transcriptional regulator from
Rhizobium loti (Mesorhizobium loti) (213 aa), FASTA
scores: opt: 172, E(): 0.00031, (23.55% identity in 204 aa
overlap); etc. Also similar to hypothetical proteins from
Mycobacterium tuberculosis strain H37Rv e.g.
P96839|Rv3557v|MTCY06G11.04c (200 aa), FASTA scores: opt:
169, E(): 0.00046, (26.75% identity in 157 aa overlap).
Contains probable helix-turn-helix motif from aa 31 to 52
(Score 1857, +5.51 SD). Similar to the TetR/AcrR family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3160c"
/db_xref="EnsemblGenomes-Tr:CCP45971"
/db_xref="GOA:O53310"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O53310"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45971.1"
/translation="MPRQAGRWSPTALRILGAAAELIALRGYSSTSTRDIAAAVGVEQ
PAIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVPAVVKLHRWLTESLDHLHASP
YVLVSILITPDLHQESFVAERELVAEMERALVGLIETGQGEGDVRAMHPLSAARLVQA
LFDALALPEFAVSPDEIVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL"
gene complement(3529990..3531138)
/locus_tag="Rv3161c"
CDS complement(3529990..3531138)
/codon_start=1
/transl_table=11
/locus_tag="Rv3161c"
/product="Possible dioxygenase"
/note="Rv3161c, (MTV014.05c), len: 382 aa. Possible
dioxygenase, similar to subunit of several dioxygenases
and related proteins e.g. BAB50510|MLR3662 dioxygenase,
alpha subunit from Rhizobium loti (Mesorhizobium loti)
(400 aa),FASTA scores: opt: 413, E(): 6.2e-20, (28.4%
identity in 331 aa overlap); Q9A3T0|CC3122 rieske 2FE-2S
family protein from Caulobacter crescentus (404 aa), FASTA
scores: opt: 405, E(): 2.1e-19, (27.95% identity in 372 aa
overlap); Q9HTF4|PA5410 probable ring hydroxylating
dioxygenase,alpha-subunit from Pseudomonas aeruginosa (429
aa), FASTA scores: opt: 392, E(): 1.6e-18, (25.8% identity
in 399 aa overlap); Q9AGK6|PHTAA phthalate dioxygenase
large subunit from Arthrobacter keyseri (473 aa), FASTA
scores: opt: 385,E(): 5.2e-18, (34.0% identity in 206 aa
overlap); P76253|YEAW_ECOLI putative dioxygenase, alpha
subunit from Escherichia coli (374 aa), FASTA scores: opt:
376, E(): 1.7e-17, (27.05% identity in 344 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3161c"
/db_xref="EnsemblGenomes-Tr:CCP45972"
/db_xref="GOA:O53311"
/db_xref="InterPro:IPR001663"
/db_xref="InterPro:IPR015879"
/db_xref="InterPro:IPR017941"
/db_xref="InterPro:IPR036922"
/db_xref="UniProtKB/TrEMBL:O53311"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45972.1"
/translation="MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQLE
RERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHALSPICRHRLMLM
VEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDFNRRECRLPQFAVATWNGLVW
INLDADAEPIAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLG
LHRQTLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKSNLVVLWTFP
NSALAIAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDED
RLGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS"
gene complement(3531208..3531645)
/locus_tag="Rv3162c"
CDS complement(3531208..3531645)
/codon_start=1
/transl_table=11
/locus_tag="Rv3162c"
/product="Possible integral membrane protein"
/note="Rv3162c, (MTV014.06c), len: 145 aa. Possible
integral membrane protein, with some similarity to
C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical
protein from Mycobacterium tuberculosis (287 aa), FASTA
scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa
overlap); and other hypothetical proteins from other
organisms."
/db_xref="EnsemblGenomes-Gn:Rv3162c"
/db_xref="EnsemblGenomes-Tr:CCP45973"
/db_xref="GOA:O53312"
/db_xref="UniProtKB/TrEMBL:O53312"
/protein_id="CCP45973.1"
/translation="MTSFAHPGTRGLSTVFGLMMVGSAAVGSHGLAVVVGLAAVIAVG
VAAVFRLAATLAVVLSVVMIVVSGPTHVLAALSGFCAAVYLVCRYGAGVVAGSWPTTV
AAVGFTFAGLAATSFPLQVPWLPLAAPLAVLATYVLATRPFSR"
gene complement(3531642..3532913)
/locus_tag="Rv3163c"
CDS complement(3531642..3532913)
/codon_start=1
/transl_table=11
/locus_tag="Rv3163c"
/product="Possible conserved secreted protein"
/note="Rv3163c, (MTV014.07c), len: 423 aa. Possible
conserved secreted protein, with some similarity to other
hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from
Streptomyces coelicolor (460 aa), FASTA scores: opt:
666,E(): 1.5e-33, (33.55% identity in 417 aa overlap);
O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA
scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa
overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410
aa),FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity
in 389 aa overlap); etc. Also some similarity with
P71761|Rv1480|MTV007.27|MTCY277.01 from Mycobacterium
tuberculosis (317 aa), FASTA scores: opt: 198, E():
6.3e-05, (26.75% identity in 269 aa overlap). Contains
PS00402 Binding-protein-dependent transport systems inner
membrane comp signature."
/db_xref="EnsemblGenomes-Gn:Rv3163c"
/db_xref="EnsemblGenomes-Tr:CCP45974"
/db_xref="InterPro:IPR002881"
/db_xref="UniProtKB/TrEMBL:O53313"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP45974.1"
/translation="MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAA
PLLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALA
GMQFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPL
TPPQSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLH
VTRRLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGG
NRPRWLGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTE
FALALIDLRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLS
WPADHSLQQSMGALPNRRRRGRGRASRARLP"
gene complement(3532943..3533905)
/gene="moxR3"
/locus_tag="Rv3164c"
CDS complement(3532943..3533905)
/codon_start=1
/transl_table=11
/gene="moxR3"
/locus_tag="Rv3164c"
/product="Probable methanol dehydrogenase transcriptional
regulatory protein MoxR3"
/note="Rv3164c, (MTV014.08c), len: 320 aa. Probable
moxR3,methanol dehydrogenase regulatory protein, highly
similar to Q9Z538|SC9B2.21c putative regulatory protein
from Streptomyces coelicolor (332 aa), FASTA scores: opt:
1227,E(): 1.7e-67, (60.25% identity in 302 aa overlap);
Q9UZ67|MOXR-3|PAB0848 methanol dehydrogenase regulatory
protein from Pyrococcus abyssi (314 aa), FASTA scores:
opt: 1126, E(): 2.3e-61, (54.1% identity in 305 aa
overlap); Q9HSH7|MOXR|VNG0223G methanol dehydrogenase
regulatory protein from Halobacterium sp. strain NRC-1
(318 aa), FASTA scores: opt: 1072, E(): 4.5e-58, (51.45%
identity in 315 aa overlap); Q9RVV4|DR0918 MOXR-related
protein from Deinococcus radiodurans (354 aa), FASTA
scores: opt: 1000,E(): 1.2e-53, (50.95% identity in 318 aa
overlap); etc. Also high similarity with several
hypothetical bacterial proteins."
/db_xref="EnsemblGenomes-Gn:Rv3164c"
/db_xref="EnsemblGenomes-Tr:CCP45975"
/db_xref="GOA:O53314"
/db_xref="InterPro:IPR011703"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041628"
/db_xref="UniProtKB/TrEMBL:O53314"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45975.1"
/translation="MIMPAATTTAHCEAVLDEIERVVVGKRSALTLILTAVLARGHVL
IEDLPGLGKTLIARSFAAALGLDFTRVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPI
FTNLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTY
PLPEAQLDRFAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVE
QVTVHEDVLHYVVSLANATRHHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDV
KELATAAVAHRITLRPEMWVRKIAGADVVSELLRRLPVPRISGT"
gene complement(3533913..3534395)
/locus_tag="Rv3165c"
CDS complement(3533913..3534395)
/codon_start=1
/transl_table=11
/locus_tag="Rv3165c"
/product="Unknown protein"
/note="Rv3165c, (MTV014.09)c, len: 160 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv3165c"
/db_xref="EnsemblGenomes-Tr:CCP45976"
/db_xref="GOA:O53315"
/db_xref="UniProtKB/TrEMBL:O53315"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45976.1"
/translation="MKRLIALGIFLIVGIELLALILHDRRLVLAGSGLALALVLLNVR
RMLGNRDELTAAPDSDDLGEGLRRWLSNTETTIRWSESTRADWDRHLRPMLARRFEIA
TGHRQAKDPVAFAATGRMLFGDELWEWVNPNNVTHTGDRQPGPGRAALEEILQKLEQV
"
gene complement(3534392..3535351)
/locus_tag="Rv3166c"
CDS complement(3534392..3535351)
/codon_start=1
/transl_table=11
/locus_tag="Rv3166c"
/product="Conserved hypothetical protein"
/note="Rv3166c, (MTV014.10c), len: 319 aa. Probable
transmembrane protein, similar but longer (52 aa) to
O32895|MLCB1779.35c hypothetical protein from
Mycobacterium leprae (119 aa), FASTA scores: opt: 289,
E(): 3.7e-10,(44.25% identity in 122 aa overlap). Also
some similarity to Q9Z536|SC9B2.23c putative transmembrane
protein from Streptomyces coelicolor (339 aa), FASTA
scores: opt: 247,E(): 2.5e-07, (28.2% identity in 326 aa
overlap); and in N-terminus to Q9RS20|DR2307 putative
multidrug-efflux transporter from Deinococcus radiodurans
(410 aa), FASTA scores: opt: 135,E(): 1, (32.35% identity
in 136 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3166c"
/db_xref="EnsemblGenomes-Tr:CCP45977"
/db_xref="GOA:O53316"
/db_xref="InterPro:IPR025403"
/db_xref="UniProtKB/TrEMBL:O53316"
/protein_id="CCP45977.1"
/translation="MPGTKPGSDKPTGRVVVVIVLLMLAGAALRGHLPADDGAPLAAA
GGSRAALMFIVAALAATLALIALAIITRLRHPLPVAPSAGELSAMLGGAAGRPNWRVL
LLGLGTILAWLLIAILLARLFVPDDVGPAAPIPDSTATPDASSTTPSRPQPPQDNNDD
VLGILFASTIGLFLMVVAGSLITSRRQRKSAPARISGDRIESPAPSARSESLARAAEI
GLAEMADLRREPREAIIACYVAMERELSHVPGVAPQDFDTPTEVLARAVEHRALHGAS
AAALVSLFAEARFSPHVMNEEHREVAMRLLRLVLDELSTRTAI"
gene complement(3535431..3536057)
/locus_tag="Rv3167c"
CDS complement(3535431..3536057)
/codon_start=1
/transl_table=11
/locus_tag="Rv3167c"
/product="Probable transcriptional regulatory protein
(probably TetR-family)"
/note="Rv3167c, (MTV014.11c), len: 208 aa. Probable
transcriptional regulator, TetR family, similar to several
transcriptional regulators e.g. Q9L2A4|SC8F4.22c
(TetR/AcrR family) from Streptomyces coelicolor (234 aa),
FASTA scores: opt: 317, E(): 7.5e-13, (33.35% identity in
210 aa overlap); Q9RK47|SCF12.11 (TetR/AcrR family) from
Streptomyces coelicolor (206 aa), FASTA scores: opt:
293,E(): 2.1e-11, (32.65% identity in 199 aa overlap);
Q54288 regulator of antibiotic transport complexes
(TetR/AcrR family) (204 aa), FASTA scores: opt: 260, E():
2.4e-09,(30.75% identity in 205 aa overlap); etc.
Equivalent to AAK47595 from Mycobacterium tuberculosis
strain CDC1551 but shorter 21 aa. Contains probable
helix-turn-helix motif from aa 42 to 63 (Score 1727, +5.07
SD). May belong to the TetR/AcrR family of transcriptional
regulators."
/db_xref="EnsemblGenomes-Gn:Rv3167c"
/db_xref="EnsemblGenomes-Tr:CCP45978"
/db_xref="GOA:O53317"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR011075"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O53317"
/protein_id="CCP45978.1"
/translation="MKADLPSLDKAPGAGRPRDPRIDSAILSATAELLVQIGYSNLSL
AAVAERAGTTKSALYRRWSSKAELVHEAAFPAAPTALQAAAGDIAADIRMMIAATRDV
FTTPVVRAALPGLVADMTADAELNARVLARFADLFAAVRMRLREAVDRGEAHPDVDPD
RLIELIGGATMLRMLLYPDDMLDDAWVDQTTAIVVRGVHRAAPGGSVV"
gene 3536102..3537238
/locus_tag="Rv3168"
CDS 3536102..3537238
/codon_start=1
/transl_table=11
/locus_tag="Rv3168"
/product="Putative aminoglycoside phosphotransferase"
/note="Rv3168, (MTV014.12), len: 378 aa. Putative
aminoglycoside phosphotransferase, similar to hypothetical
proteins e.g. Q9M7Y6|F3E22.6 from Arabidopsis thaliana
(Mouse-ear cress) (314 aa), FASTA scores: opt: 236, E():
1.1e-07, (27.35% identity in 234 aa overlap);
Q9RYW2|DRA0194 from Deinococcus radiodurans (386 aa),
FASTA scores: opt: 207, E(): 9.1e-06, (23.45% identity in
320 aa overlap); etc. Also some similarity with
O69727|Rc3761c|MTV025.109c hypothetical protein from
Mycobacterium tuberculosis (351 aa), FASTA scores: opt:
193, E(): 6.4e-05, (29.4% identity in 242 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3168"
/db_xref="EnsemblGenomes-Tr:CCP45979"
/db_xref="GOA:P9WI99"
/db_xref="InterPro:IPR002575"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR041726"
/db_xref="PDB:3ATS"
/db_xref="PDB:3ATT"
/db_xref="UniProtKB/Swiss-Prot:P9WI99"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45979.1"
/translation="MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVT
VESGVDSTGMSSETIILTARWQQDGRSIQQKLVARVAPAAEDVPVFPTYRLDHQFEVI
RLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAE
RQRQLQDATVAALATLHSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIG
RSPLLERTFEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWEMVALGPR
ELDVAWMIFAHRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSG
VMWACVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH"
gene 3537238..3538362
/locus_tag="Rv3169"
CDS 3537238..3538362
/codon_start=1
/transl_table=11
/locus_tag="Rv3169"
/product="Conserved protein"
/note="Rv3169, (MTV014.13), len: 374 aa. Conserved
protein,with similarity to other hypothetical proteins:
Q9A8W6|CC1232 from Caulobacter crescentus (368 aa), FASTA
scores: opt: 669, E(): 3.3e-34, (34.05% identity in 376 aa
overlap); and O32901|MLCB1779.41 from Mycobacterium leprae
(127 aa), FASTA scores: opt: 179, E(): 0.00034, (29.0%
identity in 131 aa overlap). Also weak similarity with
P95149|Rv1866|MTCY359.07c (804 aa), FASTA scores: opt:
121,E(): 6.4, (37.0% identity in 119 aa overlap).
Equivalent to AAK47597 from Mycobacterium tuberculosis
strain CDC1551 but shorter 43 aa."
/db_xref="EnsemblGenomes-Gn:Rv3169"
/db_xref="EnsemblGenomes-Tr:CCP45980"
/db_xref="GOA:O53319"
/db_xref="UniProtKB/TrEMBL:O53319"
/inference="protein motif:PROSITE:PS00092"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45980.1"
/translation="MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGN
IFLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLR
KLRIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVD
GERIAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLI
IQEEPDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVH
FDVESKLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHV
GRALCRDGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP"
gene 3538505..3539851
/gene="aofH"
/locus_tag="Rv3170"
CDS 3538505..3539851
/codon_start=1
/transl_table=11
/gene="aofH"
/locus_tag="Rv3170"
/product="Probable flavin-containing monoamine oxidase
AofH (amine oxidase) (MAO)"
/note="Rv3170, (MT3259, MTV014.14), len: 448 aa. Probable
aofH, flavin-containing (mono)amine oxidase, equivalent to
a predicted homologous protein from Mycobacterium
smegmatis (see citation below), and similar to many
eukaryotic monoamine oxidases e.g. P49253|AOF_ONCMY from
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) (522
aa), FASTA scores: opt: 869, E(): 5.3e-44, (37.7% identity
in 448 aa overlap); P21396|AOFA_RAT|MAOA from Rattus
norvegicus (Rat) (526 aa), FASTA scores: opt: 839, E():
3.2e-42, (37.45% identity in 446 aa overlap); Q99NA8|MAO-a
from Cavia porcellus (Guinea pig) (506 aa), FASTA scores:
opt: 836,E(): 4.6e-42, (37.0% identity in 446 aa overlap);
P21398|AOFA_BOVIN from Bos taurus (Bovine) (527 aa), FASTA
scores: opt: 806, E(): 2.8e-40, (37.0% identity in 446 aa
overlap); P21397|AOFA_HUMAN (527 aa), FASTA scores: opt:
801, E(): 5.6e-40, (37.2% identity in 446 aa overlap);
etc. Alternative start possible at position 3538487.
Belongs to the flavin monoamine oxidase family. Cofactor:
FAD (potential)."
/db_xref="EnsemblGenomes-Gn:Rv3170"
/db_xref="EnsemblGenomes-Tr:CCP45981"
/db_xref="GOA:P9WQ15"
/db_xref="InterPro:IPR001613"
/db_xref="InterPro:IPR002937"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WQ15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45981.1"
/translation="MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYR
GTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATS
SSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQDRVPGGTQQI
AQAAAAQLGARVLLNAAVRRIDRHGAGVTVTSDQGQAEAGFVIVAIPPAHRVAIEFDP
PLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADG
PGILMGFVDARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGP
TAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVAALL"
gene complement(3539846..3540745)
/gene="hpx"
/locus_tag="Rv3171c"
CDS complement(3539846..3540745)
/codon_start=1
/transl_table=11
/gene="hpx"
/locus_tag="Rv3171c"
/product="Possible non-heme haloperoxidase Hpx"
/note="Rv3171c, (MTV014.15c), len: 299 aa. Possible
hpx,non-heme haloperoxidase, similar to other hydrolases
(principaly epoxide hydrolases) and non-heme
chloroperoxidases e.g. Q9RKB6|SCE87.22c putative hydrolase
from Streptomyces coelicolor (314 aa), FASTA scores: opt:
431, E(): 6e-20, (38.05% identity in 297 aa overlap);
Q9HZ14|PA3226 probable hydrolase (similar to alpha/beta
hydrolase fold) from Pseudomonas aeruginosa (275 aa),
FASTA scores: opt: 236, E(): 1e-07, (29.6% identity in 277
aa overlap); Q9DBL9|1300003 D03RIK protein similar to
alpha/beta hydrolase fold from Mus musculus (Mouse) (351
aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35%
identity in 304 aa overlap); AAK46260|MT1988 epoxide
hydrolase from Mycobacterium tuberculosis strain CDC1551
(356 aa), FASTA scores: opt: 223, E(): 8.4e-07, (40.7%
identity in 113 aa overlap); P49323|PRXC_STRLI|CPO|CPOL
non-heme chloroperoxidase (chloride peroxidase) from
Streptomyces lividans (275 aa), FASTA scores: opt: 220,
E(): 1e-06,(29.5% identity in 305 aa overlap); etc.
Equivalent to AAK47599 Hydrolase, alpha/beta hydrolase
family from Mycobacterium tuberculosis strain CDC1551 but
shorter 24 aa. Start chosen by similarity, alternative
with good RBS possible."
/db_xref="EnsemblGenomes-Gn:Rv3171c"
/db_xref="EnsemblGenomes-Tr:CCP45982"
/db_xref="GOA:O53321"
/db_xref="InterPro:IPR022742"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53321"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45982.1"
/translation="MTVRAADGTPLHTQVFGPPHGYPIVLTHGFVCAIRAWAYQIADL
AGDYRVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAGHSMGGI
TIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELSPVRVLAGRSLVNTF
GGFPLPGAARALSRHVISTLAVAADADPSATRLVYELFTQTSAAGRGGCAKMLVEEVG
SAHLNLDGLTVPTLVIGGVRDRLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQE
VNSHLRALAESVTRHVRDRRISS"
gene complement(3540882..3541364)
/locus_tag="Rv3172c"
CDS complement(3540882..3541364)
/codon_start=1
/transl_table=11
/locus_tag="Rv3172c"
/product="Hypothetical protein"
/note="Rv3172c, (MTV014.16c), len: 160 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3172c"
/db_xref="EnsemblGenomes-Tr:CCP45983"
/db_xref="UniProtKB/TrEMBL:O53322"
/protein_id="CCP45983.1"
/translation="MSVALLREMFDRMVVAKNAELIEHYYDPDFLMYSDGLSQSFAKF
RDSHRKLYATAISYAVEYDEHAWVEAQTRLPGGCGSPRRDLARSRPASRWYSLPPTAT
AEFTGSGRRRGRVGATWPPSTITETTTDRLAMRNQLRAGAATLLFCDPMLQRFPATRK
"
gene complement(3541443..3542045)
/locus_tag="Rv3173c"
CDS complement(3541443..3542045)
/codon_start=1
/transl_table=11
/locus_tag="Rv3173c"
/product="Probable transcriptional regulatory protein
(probably TetR/AcrR-family)"
/note="Rv3173c, (MTV014.17c), len: 200 aa. Probable
transcriptional regulatory protein TetR family, similar to
several bacterial putative regulatory proteins e.g.
Q9EWI2|SC7H9.14 from Streptomyces coelicolor (195
aa),FASTA scores: opt: 319, E(): 1.7e-13, (34.55% identity
in 195 aa overlap); O85695|3SCF60.04 from Streptomyces
lividans and Streptomyces coelicolor (192 aa), FASTA
scores: opt: 297, E(): 4.3e-12, (37.45% identity in 187 aa
overlap); BAB50853|MLR4117 from Rhizobium loti
(Mesorhizobium loti) (205 aa), FASTA scores: opt: 280,
E(): 5.5e-11, (31.45% identity in 194 aa overlap);
BAB53760|MLL8133 from Rhizobium loti (Mesorhizobium loti)
(194 aa), FASTA scores: opt: 270, E(): 2.3e-10, (34.05%
identity in 185 aa overlap); etc. Also similar to other
regulators from Mycobacterium tuberculosis e.g.
P96839|Rv3557c|MTCY06G11.04c (200 aa), FASTA scores: opt:
154, E(): 0.0013, (38.8% identity in 80 aa overlap).
Contains probable helix-turn-helix motif from aa 39 to 60
(Score 1251, +3.45 SD). Similar to the TetR/AcrR family of
transcriptional regulators. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3173c"
/db_xref="EnsemblGenomes-Tr:CCP45984"
/db_xref="GOA:O53323"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O53323"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45984.1"
/translation="MPPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATGVELIA
NKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGEADKMPKASNATPRERLLALFDRPN
RGDGRMRGCPFHNAAVEAAGEMPGVERIVHSHKRDYIKGLARLAREAGAAHPRSLGNQ
LAVLFEGAAALSTSLDDAGPWAHARAAAEVLIDQATARPV"
gene 3542138..3542845
/locus_tag="Rv3174"
CDS 3542138..3542845
/codon_start=1
/transl_table=11
/locus_tag="Rv3174"
/product="Probable short-chain dehydrogenase/reductase"
/note="Rv3174, (MTV014.18), len: 235 aa. Probable
oxidoreductase short-chain dehyrogenase/reductase, similar
to others e.g. Q9RPT7|sits from Streptomyces albus (223
aa), FASTA scores: opt: 654, E(): 6.1e-32, (49.3% identity
in 215 aa overlap); Q9RI61|SCJ11.46 from Streptomyces
coelicolor (230 aa), FASTA scores: opt: 626, E():
2.9e-30,(50.9% identity in 224 aa overlap); Q9A5Z1|CC2306
from Caulobacter crescentus (252 aa), FASTA scores: opt:
430,E(): 1.3e-18, (39.45% identity in 228 aa overlap);
Q51641 insect-type dehydrogenase (249 aa), FASTA scores:
opt: 301,E(): 5.7e-11, (38.3% identity in 188 aa overlap);
Q9HXC9|PA3883 from Pseudomonas aeruginosa (276 aa), FASTA
scores: opt: 296, E(): 1.2e-10, (29.55% identity in 247 aa
overlap); etc. May belong to the short-chain
dehydrogenases/reductases (SDR) family. This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3174"
/db_xref="EnsemblGenomes-Tr:CCP45985"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53324"
/protein_id="CCP45985.1"
/translation="MTSLAERTVLVTGANRGMGREYVAQLLGRKVAKVYAATRNPLAI
DVSDPRVIPLQLDVTDAVSVAEAADLATDVGILINNAGISRASSVLDKDTSALRGELE
TNLFGPLALASAFADRIAERSGAIVNVSSVLAWLPLGMSYGVSKAAMWSATESMRIEL
APRGVQVVGVYVGLVDTDMGRFADAPKSDPADVVRQVLDGIEAGKEDVLADEMSRQVR
ASLNVPARERIARLMGN"
gene 3542860..3544347
/locus_tag="Rv3175"
CDS 3542860..3544347
/codon_start=1
/transl_table=11
/locus_tag="Rv3175"
/product="Possible amidase (aminohydrolase)"
/note="Rv3175, (MTV014.19), len: 495 aa. Possible amidase
,similar to others e.g. Q9F6D0|ZHUL enantiomer selective
amidase from Streptomyces sp. R1128 (507 aa), FASTA
scores: opt: 1328 ,E(): 7.5e-69, (44.5% identity in 492 aa
overlap); BAB51815|MLR5350 probable amidase from Rhizobium
loti (Mesorhizobium loti) (457 aa), FASTA scores: opt:
7487, E(): 1.3e-35, (35.9% identity in 482 aa overlap);
O28325|YJ54_ARCFU|AF1954 putative amidase from
Archaeoglobus fulgidus (453 aa), FASTA scores: opt:
532,E(): 3.2e-23, (32.05% identity in 471 aa overlap);
etc. But also similar to glutamyl-tRNA amidotransferases
who belong to amidase family e.g. Q9RTA9|DR1856
glutamyl-tRNA(GLN) amidotransferase, subunit A from
Deinococcus radiodurans (482 aa), FASTA scores: opt: 560,
E(): 8.2e-25, (30.6% identity in 513 aa overlap);
Q9LCX3|GATA GLU/asp-tRNA amidotransferase subunit A from
Thermus aquaticus (subsp. thermophilus) (471 aa), FASTA
scores: opt: 558, E(): 1.1e-24, (30.85% identity in 486 aa
overlap); Q49091|GATA_MORCA glutamyl-tRNA(GLN)
amidotransferase subunit A from Moraxella catarrhalis (492
aa), FASTA scores: opt: 526, E(): 7.5e-23, (30.45%
identity in 473 aa overlap); etc. Seems to belong to the
amidase family. Contains PS00017 ATP/GTP-binding site
motif A (P-loop). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3175"
/db_xref="EnsemblGenomes-Tr:CCP45986"
/db_xref="GOA:O53325"
/db_xref="InterPro:IPR023631"
/db_xref="InterPro:IPR036928"
/db_xref="UniProtKB/TrEMBL:O53325"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP45986.1"
/translation="MAMSAKASDDIAWLPATAQLAVLAAKKVSSAELVELYLSRIDTY
NASLNAIVTVDPDAARRVAKRSDAARARGDELGPLHGLPITVKDSYETAGMRTTCGRR
DLADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSG
GSAGGGAAATAAGLTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGN
PGRWGQADMACAGVQVRGARDIIPALEATVGPMRADGGFSYALAPPRAGALKDFRVAV
WAEDPHCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFA
VDRSTLSPASAAALGLRAVRHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFF
NEFDVLLLPVTPTPAPLHHNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATT
MPITTTATGLPIGIQAMGPAGGDRTTVEFAALLTEVLGGFRVPPL"
gene complement(3544344..3545300)
/gene="mesT"
/gene_synonym="lipS"
/locus_tag="Rv3176c"
CDS complement(3544344..3545300)
/codon_start=1
/transl_table=11
/gene="mesT"
/gene_synonym="lipS"
/locus_tag="Rv3176c"
/product="Probable epoxide hydrolase MesT (epoxide
hydratase) (arene-oxide hydratase)"
/note="Rv3176c, (MTV014.20c), len: 318 aa. Probable
mesT,epoxide hydrolase, similar to others e.g.
O15007|PEG1|MEST|Q92571|O14973 MEST protein (mesoderm
specific transcript (mouse) homolog) (similar to
alpha/beta hydrolase fold) from Homo sapiens (Human) (335
aa), FASTA scores: opt: 348, E(): 6e-15, (32.15% identity
in 280 aa overlap); AAH06639|Q07646 MEST protein from Mus
musculus (Mouse) (335 aa), FASTA scores: opt: 342, E():
1.4e-14,(31.45% identity in 280 aa overlap); Q9I8E7|MEST
epoxide hydrolase from Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes) (326 aa), FASTA scores: opt: 322, E():
2.7e-13, (29.55% identity in 301 aa overlap);
Q9PUC9|PEG1|MEST epoxide hydrolase from Brachydanio rerio
(Zebrafish) (Zebra danio) (344 aa), FASTA scores: opt:
322,E(): 2.8e-13, (32.35% identity in 207 aa overlap);
Q9HYH6|PA3429 probable epoxide hydrolase from Pseudomonas
aeruginosa (298 aa), FASTA scores: opt: 258, E():
3e-09,(29.85% identity in 288 aa overlap); O31243|ECHA
epoxide hydrolase from Agrobacterium radiobacter (294 aa),
FASTA scores: opt: 202, E(): 1.1e-05, (27.0% identity in
278 aa overlap); etc. Also similar to
Q50599|Rv1834|MT1882|MTCY1A11.09c hypothetical 31.7 KDA
protein from Mycobacterium tuberculosis (288 aa), FASTA
scores: opt: 294, E(): 1.5e-11, (29.95% identity in 287 aa
overlap). Equivalent to AAK47604 from Mycobacterium
tuberculosis strain CDC1551 (339 aa) but shorter 21 aa.
Similar to alpha/beta hydrolase fold. May belong to
peptidase family S33. Note that previously known as lipS.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3176c"
/db_xref="EnsemblGenomes-Tr:CCP45987"
/db_xref="GOA:Q6MX03"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:Q6MX03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45987.1"
/translation="MTHRASALISAQEWFSAGERVGYDAERPGINPRSPLRAFIRRAA
GTGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIYLDYIGHGDSDKPRDYPYSTFER
ADLVEALWHAEGIAQTVVVAFDYSCIVSLELLARRIDRERAGNDQRTRITACLLANGG
IFADGHTHAWYTTPLLTSPLGAAITPIGQRSWRMFAPFLRPVFSRGYPLSAAEMKELH
DAISRRDGVRVLPATAGFVDEHREHAARWDLARIISALGDEVAFGVVGSAEDPFEGEQ
LRLARERLADSVEITELAGGHLTTAEQPDRLAEVIAALPERS"
gene 3545447..3546307
/locus_tag="Rv3177"
CDS 3545447..3546307
/codon_start=1
/transl_table=11
/locus_tag="Rv3177"
/product="Possible peroxidase (non-haem peroxidase)"
/note="Rv3177, (MTV014.21), len: 286 aa. Possible
peroxidase (non-haem peroxidase), highly similar to
Q9KJF9|W78 cultivar specificity protein (similar to
alpha/beta hydrolase fold) W78 from Rhizobium
leguminosarum (287 aa), FASTA scores: opt: 1059, E():
2.3e-59, (61.4% identity in 272 aa overlap);
BAB48728|MLL1328 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (286 aa),FASTA scores: opt: 746, E():
1.1e-39, (43.25% identity in 282 aa overlap). Similar to
nonheme chloroperoxidases and related esterases e.g.
O73957|SAL lipolytic enzyme from Sulfolobus acidocaldarius
(314 aa), FASTA scores: opt: 408,E(): 1.9e-18, (32.4%
identity in 287 aa overlap); Q9AJM9|BIOH protein involved
in biotin synthesis from Kurthia sp. 538-KA26 (267 aa),
FASTA scores: opt: 324 ,E(): 3.2e-13, (30.0% identity in
250 aa overlap); Q9CBB1|ML2269 putative hydrolase (similar
to alpha/beta hydrolase fold) from Mycobacterium leprae
(265 aa); O05691|THCF_RHOER non-heme haloperoxidase from
Rhodococcus erythropolis (similar to other bacterial
non-heme BROMO- and chloro-peroxidases) (274 aa), FASTA
scores: opt: 279, E(): 2.2e-10, (29.0% identity in 276 aa
overlap); Q53540|est esterase (similar to alpha/beta
hydrolase fold) from Pseudomonas putida (276 aa), FASTA
scores: opt: 271, E(): 7.1e-10, (29.65% identity in 280 aa
overlap); etc. Also similar to
O06420|BPOC|Rv0554|MTCY25D10.33 hypothetical 28.3 KDA
protein (similar to alpha/beta hydrolase fold) from M.
tuberculosis (262 aa), FASTA scores: opt: 280 ,E():
1.8e-10, (28.0% identity in 257 aa overlap). Equivalent to
AAK47605 from Mycobacterium tuberculosis strain CDC1551
(300 aa) but shorter 14 aa. Similar to alpha/beta
hydrolase fold. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3177"
/db_xref="EnsemblGenomes-Tr:CCP45988"
/db_xref="GOA:O53327"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53327"
/protein_id="CCP45988.1"
/translation="MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLGADAGVPVIFL
HHLGAVLDNWDPRVVDGIAAKHPVVTFDNRGVGASEGQTPDTVTTMADDAIAFVRALG
FDQVDLLGFSLGGFVAQVIAQQEPQLVRKIILAGTGPAGGVGIGKVTFGTIRESIKAT
LTFRDPKELRFFTRTDSGKSAARQFVKRLKERKDNRDKSITVRAFRSQLKAIHAWGTQ
KPSDLTSIGHPVLIANGDDDTMVPTSNSLDLADRLPDATLRIYPDAGHGGIFQHHAQF
VDDALQFLES"
gene 3546438..3546797
/locus_tag="Rv3178"
CDS 3546438..3546797
/codon_start=1
/transl_table=11
/locus_tag="Rv3178"
/product="Conserved hypothetical protein"
/note="Rv3178, (MTV014.22), len: 119 aa. Hypothetical
protein, with some similarity to other hypothetical
bacterial proteins (principally mycobacterium and
streptomyces proteins) e.g. P71854|Rv3547|MTCY03C7.09c
from Mycobacterium tuberculosis strain H37Rv (151 aa),
FASTA scores: opt: 310, E(): 2e-14, (40.5% identity in 116
aa overlap); Q9ZH81 from M. paratuberculosis (144 aa),
FASTA scores: opt: 274, E(): 5.6e-12, (38.9% identity in
108 aa overlap); O85698|3SCF60.07 from Streptomyces
lividans and Streptomyces coelicolor (149 aa), FASTA
scores: opt: 235,E(): 2.7e-09, (35.2% identity in 108 aa
overlap); Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c (148
aa); Q9WX21|SCE68.11 from Streptomyces coelicolor (305
aa); etc. Equivalent to AAK47606 from Mycobacterium
tuberculosis strain CDC1551 (171 aa) but shorter 52 aa.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3178"
/db_xref="EnsemblGenomes-Tr:CCP45989"
/db_xref="GOA:O53328"
/db_xref="InterPro:IPR004378"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/Swiss-Prot:O53328"
/protein_id="CCP45989.1"
/translation="MRLGAGFRKPVPTLLLEHRSRKSGKNFVAPLLYITDRNNVIVVA
SALGQAENPQWYRNLPPNPDTHIQIGSDRRPVRAVVASSDERARLWPRPVDAYADFDS
CQSWTERGIPVIILRPR"
gene 3547618..3548907
/locus_tag="Rv3179"
CDS 3547618..3548907
/codon_start=1
/transl_table=11
/locus_tag="Rv3179"
/product="Conserved protein"
/note="Rv3179, (MTV014.23), len: 429 aa. Conserved
protein,highly similar to Q9KH61 putative ATP/GTP binding
protein from Mycobacterium smegmatis (428 aa), FASTA
scores: opt: 2466, E(): 1.5e-148, (89.7% identity in 428
aa overlap) (no article found on the NCBI web site (July
2001)); and to other hypothetical bacterial proteins e.g.
O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411
aa),FASTA scores: opt: 1031, E(): 8e-58, (41.5% identity
in 417 aa overlap); BAB54715|MLR9349 from Rhizobium loti
(Mesorhizobium loti) (435 aa), FASTA scores: opt: 365,
E(): 1.1e-15, (31.75% identity in 416 aa overlap); etc.
Equivalent to AAK47609 from Mycobacterium tuberculosis
strain CDC1551 (454 aa) but shorter 25 aa. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). This region
is a possible MT-complex-specific genomic island (See Becq
et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3179"
/db_xref="EnsemblGenomes-Tr:CCP45990"
/db_xref="InterPro:IPR025420"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041682"
/db_xref="UniProtKB/TrEMBL:O53329"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45990.1"
/translation="MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQ
QLHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATD
RDRRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEP
QVVLGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKR
IEQTDRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWS
RNLTAKIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAA
TELEVDLYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDE
FITGVLFYTGARALPFGDRLMALPINLLWNGQSVSSL"
gene complement(3549254..3549688)
/locus_tag="Rv3180c"
CDS complement(3549254..3549688)
/codon_start=1
/transl_table=11
/locus_tag="Rv3180c"
/product="Hypothetical alanine rich protein"
/note="Rv3180c, (MTV014.24c), len: 144 aa. Hypothetical
unknown ala-rich protein. Contains probable coiled-coil
domain from aa 40 to 70. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3180c"
/db_xref="EnsemblGenomes-Tr:CCP45991"
/db_xref="GOA:P9WF51"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF51"
/protein_id="CCP45991.1"
/translation="MPLVYFDASAFVKLLTTETGSSLASALWDGCDAALSSRLAYPEV
RAALAAAARNHDLTESELADAERDWEDFWAATRPVELTATVEQHAGHLARAHALRGAD
AVHLASALAVGDPGLVVAVWDRRLHTGAHAAGCRVAPAQLDP"
gene complement(3549691..3550143)
/locus_tag="Rv3181c"
CDS complement(3549691..3550143)
/codon_start=1
/transl_table=11
/locus_tag="Rv3181c"
/product="Conserved protein"
/note="Rv3181c, (MTV014.25c), len: 150 aa. Conserved
protein, with some similarity to other mycobacterium
proteins e.g. Q50718|YY07_MYCTU|Rv3407|MT3515|MTCY78.21c
(99 aa), FASTA scores: opt: 123, E(): 0.25, (33.7%
identity in 89 aa overlap); and O50412|Rv3385c|MTV004.43c
(102 aa),FASTA scores: opt: 123, E(): 0.26, (39.7%
identity in 68 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3181c"
/db_xref="EnsemblGenomes-Tr:CCP45992"
/db_xref="GOA:P9WF15"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:P9WF15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45992.1"
/translation="MQLGRKVTSHHDIDRFGVASTADESVYRPLPPRLRLAQVNLSRR
RCRTQSDMYKSRFSECTVQSVDVSVTELRAHLSDWLDRARAGGEVVITERGIPIARLA
ALDSTDTLERLTAEGVIGKATAQRPVAAGRPRPRPQRPVSDRVSDQRR"
gene 3550374..3550718
/locus_tag="Rv3182"
CDS 3550374..3550718
/codon_start=1
/transl_table=11
/locus_tag="Rv3182"
/product="Conserved hypothetical protein"
/note="Rv3182, (MTV014.26), len: 114 aa. Hypothetical
protein, with some similarity to other hypothetical
bacterial proteins e.g. O53468|Rv2022c|MTV018.09c from M.
tuberculosis (201 aa), FASTA scores: opt: 335, E():
3.6e-16, (51.9% identity in 104 aa overlap); and
Q9L3R6|ORF119 from Anabaena sp. strain PCC 7120 (119
aa),FASTA scores: opt: 250, E(): 1.6e-10, (42.1% identity
in 95 aa overlap). Equivalent to AAK47614 from
Mycobacterium tuberculosis strain CDC1551 (94 aa) but
longer 20 aa. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3182"
/db_xref="EnsemblGenomes-Tr:CCP45993"
/db_xref="InterPro:IPR009241"
/db_xref="UniProtKB/Swiss-Prot:O53332"
/protein_id="CCP45993.1"
/translation="MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVD
KVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLLGGDKAGNWKRWYDNNIPIADQR
SENWLASEHGGG"
gene 3550715..3551044
/locus_tag="Rv3183"
CDS 3550715..3551044
/codon_start=1
/transl_table=11
/locus_tag="Rv3183"
/product="Possible transcriptional regulatory protein"
/note="Rv3183, (MTV014.27), len: 109 aa. Possible
transcriptional regulator, similar to others e.g.
Q9S1D9|YPPCP1.08c from Yersinia pestis (99 aa), FASTA
scores: opt: 119, E(): 0.47, (40.55% identity in 74 aa
overlap); Q9X153|TM1330 from Thermotoga maritima (111
aa),FASTA scores: opt: 115, E(): 0.91, (40.35% identity in
57 aa overlap); P95258|Rv1956|MTCY09F9.08c (alias AAK46277
putative DNA-binding protein from strain CDC1551) (149
aa),FASTA scores: opt: 116, E(): 1, (42.25% identity in 71
aa overlap). Also similar to O53467|Rv2021c|MTV018.08c
from Mycobacterium tuberculosis (101 aa), FASTA scores:
opt: 214, E(): 5.8e-07, (43.0% identity in 107 aa
overlap). Contains probable helix-turn-helix motif from aa
51 to 72 (Score 1803, +5.33 SD). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3183"
/db_xref="EnsemblGenomes-Tr:CCP45994"
/db_xref="GOA:O53333"
/db_xref="InterPro:IPR001387"
/db_xref="InterPro:IPR010982"
/db_xref="InterPro:IPR039554"
/db_xref="UniProtKB/Swiss-Prot:O53333"
/protein_id="CCP45994.1"
/translation="MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEI
RKALGHARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAEFGE
NTVELTA"
repeat_region 3551227..3551229
/note="3 bp direct repeat, cga, at 5'-end of IS6110. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
mobile_element 3551230..3552584
/mobile_element_type="insertion sequence:IS6110-12"
/note="IS6110-12, len: 1355 nt. Insertion sequence IS6110.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
repeat_region 3551230..3551257
/note="28 bp inverted repeat at left end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 3551281..3551607
/locus_tag="Rv3184"
CDS 3551281..3551607
/codon_start=1
/transl_table=11
/locus_tag="Rv3184"
/product="Probable transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv3184, (MTV014.28), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv3184 and
Rv3185,the sequence UUUUAAAG (directly upstream of Rv3185)
maybe responsible for such a frameshifting event (see
McAdam et al., 1990). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3184"
/db_xref="EnsemblGenomes-Tr:CCP45995"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP45995.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <3551556..3552542
/locus_tag="Rv3185"
CDS <3551556..3552542
/codon_start=1
/transl_table=11
/locus_tag="Rv3185"
/product="Probable transposase"
/note="Rv3185, (MTV014.29), len: 328 aa. Probable IS6110
transposase. Identical to many other M. tuberculosis
IS6110 transposase subunits. The transposase described
here may be made by a frame shifting mechanism during
translation that fuses Rv3184 and Rv3185, the sequence
UUUUAAAG (directly upstream of Rv3185) maybe responsible
for such a frameshifting event (see McAdam et al., 1990).
Start changed since first submission (+ 16 aa). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3185"
/db_xref="EnsemblGenomes-Tr:CCP45996"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP45996.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(3552557..3552584)
/note="28 bp inverted repeat at right end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
repeat_region 3552585..3552587
/note="3 bp direct repeat, cga, at 3'-end of IS6110. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
repeat_region 3552710..3552712
/note="3 bp direct repeat, att, at 5'-end of IS6110. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
mobile_element 3552713..3554067
/mobile_element_type="insertion sequence:IS6110-13"
/note="IS6110-13, len: 1355 nt. Insertion sequence IS6110.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
repeat_region 3552713..3552740
/note="28 bp inverted repeat at left end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 3552764..3553090
/locus_tag="Rv3186"
CDS 3552764..3553090
/codon_start=1
/transl_table=11
/locus_tag="Rv3186"
/product="Probable transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv3186, (MTV014.30), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv3186 and
Rv3187,the sequence UUUUAAAG (directly upstream of Rv3187)
maybe responsible for such a frameshifting event (see
McAdam et al., 1990). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3186"
/db_xref="EnsemblGenomes-Tr:CCP45997"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP45997.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <3553039..3554025
/locus_tag="Rv3187"
CDS <3553039..3554025
/codon_start=1
/transl_table=11
/locus_tag="Rv3187"
/product="Probable transposase"
/note="Rv3187, (MTV014.31), len: 328 aa. Probable IS6110
transposase. Identical to many other M. tuberculosis
IS6110 transposase subunits. The transposase described
here may be made by a frame shifting mechanism during
translation that fuses Rv3186 and Rv3187, the sequence
UUUUAAAG (directly upstream of Rv3187) maybe responsible
for such a frameshifting event (see McAdam et al., 1990).
Start changed since first submission (+ 16 aa). This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3187"
/db_xref="EnsemblGenomes-Tr:CCP45998"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP45998.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(3554040..3554067)
/note="28 bp inverted repeat at right end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
repeat_region 3554068..3554070
/note="3 bp direct repeat, att, at 5'-end of IS6110. This
region is a possible MT-complex-specific genomic island
(See Becq et al., 2007)."
gene 3554298..3554645
/locus_tag="Rv3188"
CDS 3554298..3554645
/codon_start=1
/transl_table=11
/locus_tag="Rv3188"
/product="Conserved hypothetical protein"
/note="Rv3188, (MTV014.32), len: 115 aa. Conserved
hypothetical protein, with similarity to other proteins
from Mycobacterium tuberculosis:
Q10868|YJ90_MYCTU|Rv1990c|MT2044|MTCY39.29 hypothetical
protein (113 aa), FASTA scores: opt: 184, E():
8.1e-06,(28.45% identity in 109 aa overlap); and
O06299|Rv0348|MTCY13E10.08 hypothetical protein (217
aa),FASTA scores: opt: 129, E(): 0.074, (30.0% identity in
100 aa overlap). Also some similarity with C-terminus of
Q9XA59|SCGD3.19 putative two-component system response
transcriptional regulator from Streptomyces coelicolor
(218 aa), FASTA scores: opt: 114, E(): 0.76, (30.0%
identity in 110 aa overlap) (for this one, no similarity
exists in the N-terminal region with the N-terminus of
other regulatory components of sensory transduction
systems). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3188"
/db_xref="EnsemblGenomes-Tr:CCP45999"
/db_xref="InterPro:IPR024467"
/db_xref="UniProtKB/TrEMBL:O53334"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP45999.1"
/translation="MAVTLDRAVEASEIVDALKPFGVTQVDVAAVIQVSDRAVRGWRT
GDIRPERYDRLAQLRDLVLLLSDSLTPRGVGQWLHAKNRLLDGQRPVDLLAKDRYEDV
RSAAESFIDGAYV"
gene 3554642..3555262
/locus_tag="Rv3189"
CDS 3554642..3555262
/codon_start=1
/transl_table=11
/locus_tag="Rv3189"
/product="Conserved hypothetical protein"
/note="Rv3189, (MTV014.33), len: 206 aa. Conserved
hypothetical protein, weakly similar to other proteins
from Mycobacterium tuberculosis e.g.
O86329|MBTE|Rv2380c|MTCY22H8.05 (1682 aa), FASTA scores:
opt: 135, E(): 0.79, (27.8% identity in 187 aa overlap);
and Q10869|YJ89_MYCTU|Rv1989c|MT2043MTCY39.30 (186
aa),FASTA scores: opt: 122, E(): 0.85, (32.25% identity in
93 aa overlap). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3189"
/db_xref="EnsemblGenomes-Tr:CCP46000"
/db_xref="InterPro:IPR014914"
/db_xref="UniProtKB/TrEMBL:O53335"
/protein_id="CCP46000.1"
/translation="MKLADAIATAPRRTLKGTYWHQGPTRHPVTSCADPARGPGRYHR
TGEPGVWYASNKEQGAWAELFRHFVDDGVDPFEVRRRVGRVAVTLQVLDLTDERTRSH
LGVDETDLLSDDYTTTQAIAAARDANFDAVLAPAAALPGCQTLAVFVHALPNIEPERS
EVRQPPPRLANLLPLIRPHEHMPDSVRRLLATLTRAGAEAIRRRRR"
gene complement(3555422..3556687)
/locus_tag="Rv3190c"
CDS complement(3555422..3556687)
/codon_start=1
/transl_table=11
/locus_tag="Rv3190c"
/product="Hypothetical protein"
/note="Rv3190c, (MTV014.34c), len: 421 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3190c"
/db_xref="EnsemblGenomes-Tr:CCP46001"
/db_xref="GOA:O53336"
/db_xref="UniProtKB/TrEMBL:O53336"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46001.1"
/translation="MEYVQLFSKGRLNDLAGSLAGFLGKASQATAQRLQSWDADDLLN
TPVDDVVEQLVELGSVECPDLRVDDAFMLPATEVDQQYRDWGEQRTRRVTRLVLVVPF
EGHKDIFNLRPDQFTTMPPQVLRLQGHEIHLAIDNLSNDAAAINAAFHKQIANIEKYL
GWSRRQIDLHNQGLRNELPGMVARRREQLLATRNLQAEIGFPVRRRKDADTYAAPISR
KSVRPRPHRPAGARAAFKPEPAMQDEDYQSALRVLRNQRNALERTPSVAAKLDGEEIR
DMLLVGLNAQFEGDAGGELFNGAGKTDILIRVDDRNIFIGECKVWSGPRTMDDVLKQL
FGYLVWRDTKAAILLFIRNKDVTAVIDNAIAKIKEHPNHKRCPAHRAGADQYEFTMHA
DGDPEREIHLTLIPFALRPTAEVPTTTIP"
gene 3556855..3557064
/locus_tag="Rv3190A"
CDS 3556855..3557064
/codon_start=1
/transl_table=11
/locus_tag="Rv3190A"
/product="Conserved protein"
/note="Rv3190A, len: 69 aa. Conserved protein."
/db_xref="EnsemblGenomes-Gn:Rv3190A"
/db_xref="EnsemblGenomes-Tr:CCP46002"
/db_xref="UniProtKB/TrEMBL:I6XGJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46002.1"
/translation="MITVLDMNGFKDARPDRLPLSASVWDIAQRYNKGGPTVTEALYE
ALKELEAQVIALQRSEGKGLLSRLS"
gene complement(3557311..3558345)
/locus_tag="Rv3191c"
CDS complement(3557311..3558345)
/codon_start=1
/transl_table=11
/locus_tag="Rv3191c"
/product="Probable transposase"
/note="Rv3191c, (MTV014.35c), len: 344 aa. Probable
transposase, similar to many especially Q9K2N8 putative
transposase from Pseudomonas aeruginosa (338 aa), FASTA
scores: opt: 837, E(): 1.3e-43, (42.55% identity in 336 aa
overlap); Q9RBF4 insertion sequence IS1088 from
Alcaligenes eutrophus (Ralstonia eutropha) (342 aa), FASTA
scores: opt: 823, E(): 9.2e-43, (43.05% identity in 337 aa
overlap); and Q51379 putative transposase from Pseudomonas
alcaligenes (338 aa), FASTA scores: opt: 818, E():
1.8e-42, (42.35% identity in 333 aa overlap). Contains
probable helix-turn-helix motif from aa 25 to 46 (Score
1968, +5.89 SD). This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
/db_xref="EnsemblGenomes-Gn:Rv3191c"
/db_xref="EnsemblGenomes-Tr:CCP46003"
/db_xref="GOA:O53337"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025246"
/db_xref="UniProtKB/TrEMBL:O53337"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46003.1"
/translation="MRQISSRYLSEEERINIADLRRSGLSIRKIADQLGRAPSTVSRE
LRRNSRRDGQYRPFEAHRWAVQRRVRRHRRRIDKNPDLCELIAELLAQRWSPQQIARH
LRRKYPDDRSMWLCHESIYQAVYQPQSRLIRPPQVKSPHRGPLRTGRTHRRAHLRPGR
RRPRFAQPMLSIHQRPFDPADRSEPGHWEGDLIVGKNQGSAIGTLVERQTRLIRLLHL
PTHDAYCLRIAITETMSDLPVTLVRSITWDQGIEMARHIDITADLGAPVYFCDSRSPW
QRASNENSNGLLRQYFPKGTSLSTYTPDHLRAVEYEINNRPRQVLGHRSPAELFTALL
TSPDHQLLRR"
mobile_element complement(3557314..3558345)
/mobile_element_type="insertion sequence:IS1603"
/locus_tag="Rv3191c"
/note="IS1603, len: 1032 nt. Insertion sequence IS1603.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
gene complement(3559370..3559443)
/gene="metU"
tRNA complement(3559370..3559443)
/gene="metU"
/product="tRNA-Met"
/anticodon=(pos:complement(3559407..3559409),aa:Met,
seq:cat)
/note="codon recognized: AUG; metU, tRNA-fMet, anticodon
cat, length = 74. Described in EM_BA: MTMETA Y08623
M.tuberculosis as metA gene. Name changed to metU as metA
encodes homoserine transsuccinylase. This region is a
possible MT-complex-specific genomic island (See Becq et
al.,2007)."
gene 3559563..3560024
/locus_tag="Rv3192"
CDS 3559563..3560024
/codon_start=1
/transl_table=11
/locus_tag="Rv3192"
/product="Conserved hypothetical alanine and proline-rich
protein"
/note="Rv3192, (MTV014.36), len: 153 aa. Conserved
hypothetical ala- and pro-rich protein, with weak
similarity to N-terminal half of several proteins e.g.
Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 hypothetical
37.3 KDA protein from Mycobacterium tuberculosis (340
aa),FASTA scores: opt: 245, E(): 3.7e-08, (33.1% identity
in 157 aa overlap); O30260|AF2411 conserved hypothetical
protein from Archaeoglobus fulgidus (363 aa), FASTA
scores: opt: 144, E(): 0.072, (32.6% identity in 92 aa
overlap); Q9ZA30|GRA-ORF29 putative FMN-dependent
monooxygenase from Streptomyces violaceoruber (343 aa),
FASTA scores: opt: 133, E(): 0.33, (25.15% identity in 159
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3192"
/db_xref="EnsemblGenomes-Tr:CCP46004"
/db_xref="GOA:O53338"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:O53338"
/protein_id="CCP46004.1"
/translation="MIPQPLSQLGDLARRPGRRVLCSPKTAAPSISNATVASPAAPGL
ELSTGIALAFPRGPFVPAAAAWELQEATSGKFQLGLGTQVRKNVVHRYGMAFHRPGPR
LRYLLAVKACFAVFQTGTPDHHGEFDNPDFITAQWSPARIDPPGPSPAGPR"
gene complement(3560194..3563172)
/locus_tag="Rv3193c"
CDS complement(3560194..3563172)
/codon_start=1
/transl_table=11
/locus_tag="Rv3193c"
/product="Probable conserved transmembrane protein"
/note="Rv3193c, (MTV014.37c), len: 992 aa. Probable
conserved transmembrane protein, with hydrophobic
N-terminal domain (~1-340 aa), highly similar to
Q9CCM6|ML0644 putative integral membrane protein from
Mycobacterium leprae (983 aa), FASTA scores: opt:
5421,E(): 0, (86.15% identity in 989 aa overlap); and
O53609|Rv0064|MTV030.07 putative membrane protein from
Mycobacterium tuberculosis strain H37Rv (979 aa), FASTA
scores: opt: 3204, E(): 2.1e-142, (50.25% identity in 985
aa overlap). C-terminal part (709-990 aa) highly similar
to O32904|MLCB1779.46 hypothetical 29.1 KDA protein from
Mycobacterium leprae (277 aa), FASTA scores: opt:
1521,E(): 3.4e-64, (82.6% identity in 282 aa overlap).
Also some similarity to hypothetical proteins generally
transmembrane e.g. Q9FCI4|2SC3B6.28 from Streptomyces
coelicolor (815 aa), FASTA scores: opt: 951, E(): 3.4e-37,
(39.2% identity in 826 aa overlap); P72637|SLL1060 from
Synechocystis sp. strain PCC 6803 (1032 aa), FASTA scores:
opt: 938, E(): 1.6e-36, (29.95% identity in 855 aa
overlap); O28851|AF1421 from Archaeoglobus fulgidus (880
aa), FASTA scores: opt: 526, E(): 2.6e-17, (28.05%
identity in 970 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3193c"
/db_xref="EnsemblGenomes-Tr:CCP46005"
/db_xref="GOA:P9WFL3"
/db_xref="InterPro:IPR005372"
/db_xref="UniProtKB/Swiss-Prot:P9WFL3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46005.1"
/translation="MGMRSAARMPKLTRRSRILIMIALGVIVLLLAGPRLIDAYVDWL
WFGELGYRSVFTTMLATRIVVCLVAGVVVGGIVFGGLALAYRTRPVFVPDADNDPVAR
YRAVVLARLRLVGIGIPAAIGLLAGIVAQSYWARIQLFLHGGDFGVRDPQFGRDLGFY
AFELPFYRLMLSYMLVSVFLAFVANLVAHYIFGGIRLSGRTGALSRSARVQLVSLVGV
LVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAAAVFSA
IALRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSITATRQA
YGLTSDVVTYRNYSGDSPATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYF
PDQLSIDRYLDRNGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANT
VRGIANDPNQNGGYPEFLVNVVGANGTVVSDGPAPLDQPRIYFGPVISNTSADYAIVG
RNGDDREYDYETNIDTKRYTYTGSGGVPLGGWLARSVFAAKFAERNFLFSNVIGSNSK
ILFNRDPAQRVEAVAPWLTTDSAVYPAIVNKRLVWIVDGYTTLDNYPYSELTSLSSAT
ADSNEVAFNRLVPDKKVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMQVFPGTV
KPKSDIAPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASS
YQPPYYIVAKNIAKDDNSASYQLISAMNRFKRDYLAAYISASSDPATYGNLTVLTIPG
QVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVARGGLLYVEPVYASP
GASDAASSYPRLIRVAMMYNDKVGYGPTVRDALTGLFGPGAGATATGIAPTEAAVPPS
PAANPPPPASGPQPPPVTAAPPVPVGAVTLSPAKVAALQEIQAAIGAARDAQKKGDFA
AYGSALQRLDEAITKFNDAG"
gene complement(3563264..3564286)
/locus_tag="Rv3194c"
CDS complement(3563264..3564286)
/codon_start=1
/transl_table=11
/locus_tag="Rv3194c"
/product="Possible conserved secreted protein"
/note="Rv3194c, (MTV014.38c), len: 340 aa. Possible
conserved secreted protein (N-terminal stretch
hydrophobic), equivalent to Q9CCM7|ML0643 putative
secreted protein from Mycobacterium leprae (340 aa), FASTA
scores: opt: 1822, E(): 1.6e-102, (80.3% identity in 340
aa overlap). Also similar to other proteins e.g.
Q9FCI6|2SC3B6.26 putative secreted protein from
Streptomyces coelicolor (364 aa), FASTA scores: opt:
430,E(): 1.1e-18, (40.95% identity in 359 aa overlap);
Q9S3Y5|SDRC SDRC protein from Streptomyces coelicolor (241
aa), FASTA scores: opt: 396, E(): 8.9e-17, (35.2% identity
in 318 aa overlap) (similarity in part for this one);
O34470|YLBL YLBL protein from Bacillus subtilis (350
aa),FASTA scores: opt: 385, E(): 5.6e-16, (27.7% identity
in 350 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3194c"
/db_xref="EnsemblGenomes-Tr:CCP46006"
/db_xref="GOA:O53340"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR008269"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR027065"
/db_xref="InterPro:IPR036034"
/db_xref="UniProtKB/TrEMBL:O53340"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46006.1"
/translation="MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEI
DGKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGK
SREEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAV
DGTPVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVV
DAPWAPFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQ
IGGITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSG
SPTPSC"
gene 3564364..3565782
/locus_tag="Rv3195"
CDS 3564364..3565782
/codon_start=1
/transl_table=11
/locus_tag="Rv3195"
/product="Conserved hypothetical protein"
/note="Rv3195, (MTV014.39), len: 472 aa. Hypothetical
protein, equivalent to Q49746|ML0642|B1937_C3_231
hypothetical 50.3 KDA protein from Mycobacterium leprae
(479 aa), FASTA scores: opt: 2503, E(): 1e-138, (79.35%
identity in 475 aa overlap). Similar in part to
Q9FCI9|2SC3B6.23c conserved hypothetical protein from
Streptomyces coelicolor (487 aa), FASTA scores: opt:
1382,E(): 2.7e-73, (46.4% identity in 489 aa overlap);
Q9X8I7|SCE9.14 hypothetical 41.2 KDA protein from
Streptomyces coelicolor (375 aa), FASTA scores: opt:
319,E(): 2.4e-11, (25.6% identity in 383 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3195"
/db_xref="EnsemblGenomes-Tr:CCP46007"
/db_xref="InterPro:IPR018766"
/db_xref="UniProtKB/TrEMBL:O53341"
/protein_id="CCP46007.1"
/translation="MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPL
GAFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIA
PIPAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMA
QQISTVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLP
LGPKGVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVE
AYAMGMKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETL
LALIEGWVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLR
EAGALWERLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAE
LERDQQARGADDSGHDGGPVDN"
gene 3565788..3566687
/locus_tag="Rv3196"
CDS 3565788..3566687
/codon_start=1
/transl_table=11
/locus_tag="Rv3196"
/product="Conserved hypothetical protein"
/note="Rv3196, (MTV014.40), len: 299 aa. Hypothetical
protein, with some similarity to other hypothetical
proteins e.g. Q9FCJ5|2SC3B6.17c putative secreted protein
from Streptomyces coelicolor (442 aa), FASTA scores: opt:
233, E(): 3.5e-07, (29.9% identity in 261 aa overlap).
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3196"
/db_xref="EnsemblGenomes-Tr:CCP46008"
/db_xref="UniProtKB/TrEMBL:O53342"
/protein_id="CCP46008.1"
/translation="MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRR
AVLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGV
ATPLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVD
LVVLSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSD
RDAAWPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTT
LEFDLNAGSIVARQWTRHPRCFC"
gene complement(3566696..3566896)
/locus_tag="Rv3196A"
CDS complement(3566696..3566896)
/codon_start=1
/transl_table=11
/locus_tag="Rv3196A"
/product="Unknown protein"
/note="Rv3196A, len: 66 aa. Unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3196A"
/db_xref="EnsemblGenomes-Tr:CCP46009"
/db_xref="UniProtKB/TrEMBL:L7N668"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46009.1"
/translation="MQEGGPQETMSARSTQHDAADALFRAIIETLDKHRNERTLTEDV
LDTLARAYASISTNVPEQGRLG"
gene 3567024..3568367
/locus_tag="Rv3197"
CDS 3567024..3568367
/codon_start=1
/transl_table=11
/locus_tag="Rv3197"
/product="Probable conserved ATP-binding protein ABC
transporter"
/note="Rv3197, (MTV014.41), len: 447 aa. Probable
conserved ATP-binding protein ABC transporter, highly
similar to Mycobacterium leprae proteins: Q9CCM8|ML0640
hypothetical protein (473 aa), FASTA scores: opt: 2512,
E(): 2.1e-140,(83.0% identity in 447 aa overlap).
Interestingly, the N-terminal half (1-219 aa) corresponds
to Q49747|ABC1|B1937_C3_233 ABC1 protein from
Mycobacterium leprae (267 aa), FASTA scores: opt: 1276,
E(): 6.3e-68,(88.6% identity in 219 aa overlap); and the
C-terminal half (239-447 aa) corresponds to
Q49745|B1937_C2_179 hypothetical 23.1 KDA protein (206
aa), FASTA scores: opt: 1138, E(): 6.5e-60, (77.05%
identity in 209 aa overlap); two adjacent orfs from
Mycobacterium leprae. Also highly similar to other
proteins (generally ABC transporters) e.g.
Q9FCJ6|2SC3B6.16c hypothetical 51.3 KDA protein from
Streptomyces coelicolor (469 aa), FASTA scores: opt:
1340,E(): 1.8e-71, (45.9% identity in 449 aa overlap);
O65576|ABC1AT ABC1 protein (alias
Q9SBB2|T15B16.14|AT4G01660 putative ABC transporter) from
Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA
scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa
overlap); O27682|MTH1645 ABC transporter from
Methanobacterium thermoautotrophicum (623 aa), FASTA
scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Belongs to the ATP-binding transport protein
family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv3197"
/db_xref="EnsemblGenomes-Tr:CCP46010"
/db_xref="GOA:O53343"
/db_xref="InterPro:IPR002575"
/db_xref="InterPro:IPR004147"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR034646"
/db_xref="PDB:5YJZ"
/db_xref="PDB:5YK0"
/db_xref="PDB:5YK1"
/db_xref="PDB:5YK2"
/db_xref="UniProtKB/TrEMBL:O53343"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46010.1"
/translation="MDDGSVSDIKRGRAARNAKLASIPVGFAGRAALGLGKRLTGKSK
DEVTAELMEKAANQLFTVLGELKGGAMKVGQALSVMEAAIPDEFGEPYREALTKLQKD
APPLPASKVHRVLDGQLGTKWRERFSSFNDTPVASASIGQVHKAIWSDGREVAVKIQY
PGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEMELDYRLEAANQRAFA
KAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDA
PRRLGLMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGGFPIELGMTIRLAREKNYDLL
LPTMEKAGLIQRGRQVSVREIDEMLRQYVEPIQVEVFHYTRKWLQKMTVSQIDRSVAQ
IRTARQMDLPAKLAIPMRVIASVGAILCQLDAHVPIKALSEELIPGFAEPDAIVV"
gene complement(3568401..3568679)
/gene="whiB7"
/gene_synonym="whmC"
/locus_tag="Rv3197A"
CDS complement(3568401..3568679)
/codon_start=1
/transl_table=11
/gene="whiB7"
/gene_synonym="whmC"
/locus_tag="Rv3197A"
/product="Probable transcriptional regulatory protein
WhiB-like WhiB7"
/note="Rv3197A, len: 92 aa. Probable whiB7 (alternate gene
name: whmC), WhiB-like regulatory protein (see citation
below), similar to WhiB paralogue of Streptomyces
coelicolor, wblE gene product (85 aa). Equivalent to
Q49765|WHIB7|ML0639|B1937_F2_68 putative transcriptional
regulator WHIB7 from Mycobacterium leprae (89 aa), FASTA
scores: opt: 441, E(): 6.3e-24, (69.3% identity in 88 aa
overlap). Similar to Q9FCJ8|2SC3B6.14 putative DNA-binding
protein from Streptomyces coelicolor (122 aa), FASTA
scores: opt: 348, E(): 2.2e-17, (57.7% identity in 78 aa
overlap); Q9AD55|SCP1.95 putative regulatory protein from
Streptomyces coelicolor (102 aa), FASTA scores: opt:
166,E(): 7.1e-05, (39.4% identity in 76 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3197A"
/db_xref="EnsemblGenomes-Tr:CCP46011"
/db_xref="GOA:Q6MX01"
/db_xref="InterPro:IPR003482"
/db_xref="InterPro:IPR017956"
/db_xref="InterPro:IPR034768"
/db_xref="UniProtKB/Swiss-Prot:Q6MX01"
/protein_id="CCP46011.1"
/translation="MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCV
SCPIRRQCLAAALQRAEPWGVWGGEIFDQGSIVSHKRPRGRPRKDAVA"
gene complement(3569109..3571211)
/gene="uvrD2"
/locus_tag="Rv3198c"
CDS complement(3569109..3571211)
/codon_start=1
/transl_table=11
/gene="uvrD2"
/locus_tag="Rv3198c"
/product="Probable ATP-dependent DNA helicase II UvrD2"
/note="Rv3198c, (MTV014.42c), len: 700 aa. Probable
UvrD2,ATP dependent DNA helicase II (see citation
below),equivalent to
P53528|UVRD_MYCLE|VRD|UVRD2|ML0637|B1937_F1_27 probable
DNA helicase II homolog from Mycobacterium leprae (717
aa),FASTA scores: opt: 3749, E(): 0, (82.85% identity in
706 aa overlap); and C-terminal half (466-700 aa)
corresponds to Q49764|RECQ|B1937_F2_66 putative DNA
helicase RECQ (242 aa), FASTA scores: opt: 1267, E():
1.4e-69, (82.5% identity in 234 aa overlap); products of
two adjacent ORFS in Mycobacterium leprae. Also similar to
other DNA helicases e.g. Q9FCK0|2SC3B6.12 from
Streptomyces coelicolor (785 aa), FASTA scores: opt: 1687,
E(): 1.2e-94, (52.05% identity in 728 aa overlap);
P71561|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c ATP-dependent
DNA helicase PCRA from Mycobacterium tuberculosis (771
aa),FASTA scores: opt: 715, E(): 1e-35, (34.1% identity in
710 aa overlap); Q9CD72|PCRA_MYCLE|UVRD|ML0153
ATP-dependent DNA helicase PCRA from Mycobacterium leprae
(778 aa), FASTA scores: opt: 687, E(): 5.1e-34, (32.0%
identity in 719 aa overlap); O83991|TP1028 DNA helicase II
(UVRD) from Treponema pallidum (670 aa), FASTA scores:
opt: 652, E(): 6e-32, (30.25% identity in 671 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop). Belongs to the UVRD subfamily of helicases."
/db_xref="EnsemblGenomes-Gn:Rv3198c"
/db_xref="EnsemblGenomes-Tr:CCP46012"
/db_xref="GOA:P9WMP9"
/db_xref="InterPro:IPR000212"
/db_xref="InterPro:IPR002121"
/db_xref="InterPro:IPR010997"
/db_xref="InterPro:IPR013986"
/db_xref="InterPro:IPR014016"
/db_xref="InterPro:IPR014017"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR034739"
/db_xref="UniProtKB/Swiss-Prot:P9WMP9"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP46012.1"
/translation="MSIASDPLIAGLDDQQREAVLAPRGPVCVLAGAGTGKTRTITHR
IASLVASGHVAAGQVLAVTFTQRAAGEMRSRLRALDAAARTGSGVGAVQALTFHAAAY
RQLRYFWSRVIADTGWQLLDSKFAVVARAASRTRLHASTDDVRDLAGEIEWAKASLIG
PEEYVTAVAAARRDPPLDAAQIAAVYSEYEALKARGDGVTLLDFDDLLLHTAAAIEND
AAVAEEFQDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGASP
RFLLDFSRRFPDAAVVRLERDYRSTPQVVSLANRVIAAARGRVAGSKLRLSGQREPGP
VPSFHEHSDEPAEAATVAASIARLIASGTPPSEVAILYRVNAQSEVYEEALTQAGIAY
QVRGGEGFFNRQEIKQALLALQRVSERDTDAALSDVVRAVLAPLGLTAQPPVGTRARE
RWEALTALAELVDDELAQRPALQLPGLLAELRRRAEARHPPVVQGVTLASLHAAKGLE
WDAVFLVGLADGTLPISHALAHGPNSEPVEEERRLLYVGITRARVHLALSWALSRSPG
GRQSRKPSRFLNGIAPQTRADPVPGTSRRNRGAAARCRICNNELNTSAAVMLRRCETC
AADVDEELLLQLKSWRLSTAKEQNVPAYVVFTDNTLIAIAELLPTDDAALIAIPGIGA
RKLEQYGSDVLQLVRGRT"
gene 3571335..3571589
/locus_tag="Rv3198A"
CDS 3571335..3571589
/codon_start=1
/transl_table=11
/locus_tag="Rv3198A"
/product="Possible glutaredoxin protein"
/note="Rv3198A, len: 84 aa. Possible glutaredoxin protein
,highly similar to Q9FCK1|2SC3B6.11c putative
glutaredoxin-like protein from Streptomyces coelicolor (80
aa), FASTA scores: opt: 293, E(): 2.2e-14, (55.15%
identity in 78 aa overlap); and Q9RSN9|DR2085 putative
glutaredoxin from Deinococcus radiodurans (81 aa), FASTA
scores: opt: 198, E(): 1.2e-07, (53.55% identity in 56 aa
overlap). Also similar to several hypothetical bacterial
proteins e.g. Q9X8C2|SCE36.09 hypothetical 13.0 KDA
protein from Streptomyces coelicolor (114 aa), FASTA
scores: opt: 181,E(): 2.6e-06, (44.45% identity in 72 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3198A"
/db_xref="EnsemblGenomes-Tr:CCP46013"
/db_xref="GOA:P9WN17"
/db_xref="InterPro:IPR002109"
/db_xref="InterPro:IPR011915"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:2LQO"
/db_xref="PDB:2LQQ"
/db_xref="UniProtKB/Swiss-Prot:P9WN17"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46013.1"
/translation="MITAALTIYTTSWCGYCLRLKTALTANRIAYDEVDIEHNRAAAE
FVGSVNGGNRTVPTVKFADGSTLTNPSADEVKAKLVKIAG"
gene complement(3571602..3572543)
/gene="nudC"
/locus_tag="Rv3199c"
CDS complement(3571602..3572543)
/codon_start=1
/transl_table=11
/gene="nudC"
/locus_tag="Rv3199c"
/product="Probable NADH pyrophosphatase NudC (NAD+
diphosphatase) (NAD+ pyrophosphatase) (NADP
pyrophosphatase)"
/note="Rv3199c, (MTV014.43)c, len: 313 aa. Probable
nudC,NADH pyrophosphatase, similar in particular to
Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356
aa),FASTA scores: opt: 493, E(): 7.4e-24, (39.65% identity
in 232 aa overlap); Q9ABG1|CC0266 mutt/NUDIX family
protein from Caulobacter crescentus (313 aa), FASTA
scores: opt: 479, E(): 5.1e-23, (38.3% identity in 222 aa
overlap); O86062|NUDC_PSEAE|NUDC|PA1823 NADH
pyrophosphatase from Pseudomonas aeruginosa (278 aa),
FASTA scores: opt: 371,2 E(): 3e-16, (43.15% identity in
153 aa overlap); Q9RV62|NUDC_DEIRA|NUDC|DR1168 NADH
pyrophosphatase from Deinococcus radiodurans (280 aa),
FASTA scores: opt: 363,E(): 9.6e-16, (34.45% identity in
270 aa overlap); etc. Caution: equivalent to AAK47636 from
Mycobacterium tuberculosis strain CDC1551 (386 aa) but
shorter 72 aa. Contains PS00893 mutT domain signature.
Belongs to the NUDIX hydrolase family, NUDC subfamily.
Cofactor: requires divalent ions: manganese or magnesium."
/db_xref="EnsemblGenomes-Gn:Rv3199c"
/db_xref="EnsemblGenomes-Tr:CCP46014"
/db_xref="GOA:P9WIX5"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015375"
/db_xref="InterPro:IPR015376"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR020084"
/db_xref="InterPro:IPR022925"
/db_xref="UniProtKB/Swiss-Prot:P9WIX5"
/inference="protein motif:PROSITE:PS00893"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46014.1"
/translation="MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAAL
LRVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPD
IPAEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNP
ITGHEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVARE
IREEIGLTVRDVRYLGSQQWPFPRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEV
RAALAAGDWSSASESKLLLPGSISIARVIIESWAACE"
gene complement(3572602..3573669)
/locus_tag="Rv3200c"
CDS complement(3572602..3573669)
/codon_start=1
/transl_table=11
/locus_tag="Rv3200c"
/product="Possible transmembrane cation transporter"
/note="Rv3200c, (MTV014.44c), len: 355 aa. Possible
transmembrane cation transporter, similar to many
transmembrane proteins and putative potassium channels
e.g. Q9XA52|SCGD3.27C putative membrane protein from
Streptomyces coelicolor (365 aa), FASTA scores: opt:
1022,E(): 2.6e-53, (49.85% identity in 325 aa overlap);
Q9RRZ3|DR2336 putative potassium channel from Deinococcus
radiodurans (320 aa), FASTA scores: opt: 436, E():
1e-18,(30.9% identity in 304 aa overlap); O28600|AF1673
putative potassium channel from Archaeoglobus fulgidus
(314 aa),FASTA scores: opt: 363, E(): 2.1e-14, (27.2%
identity in 309 aa overlap);
Q57604|Y13B_METJAMJ0138.1|MJ0138.1 putative potassium
channel from Methanococcus jannaschii (333 aa), FASTA
scores: opt: 356, E(): 5.7e-14, (26.0% identity in 281 aa
overlap); P73132|SLL0993 potassium channel from
Synechocystis sp. strain PCC 6803 (365 aa),FASTA scores:
opt: 330, E(): 2.1e-12, (27.8% identity in 324 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3200c"
/db_xref="EnsemblGenomes-Tr:CCP46015"
/db_xref="GOA:O53346"
/db_xref="InterPro:IPR003148"
/db_xref="InterPro:IPR013099"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53346"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46015.1"
/translation="MAGSWRRLRGLNEKLTAQPGYALVGVLRIPQRRASPARVISRRV
VVAVVALLLTAGIVYVDRDGYLDAQGDRLTFLDCLYYAAVTLSTTGYGDITPISEFAR
AINIFVITPLRIAFLILLVGTTLEVLTETSRQAYKIQRWRSRVRNHTVVIGYGTKGKT
AVAAMVSDELVPGEIVVVDTDSGVLERAAAAGLVTVHGDATKSDVLRLAGTQHASSII
VATSRDDTAVLVTLTAREIAPKAKIVASIREAENQHLLRQSGADTVVVSSETAGRLLG
IATTTPSVVEMIEDLLTPEAGLAVAEREVEQAEVGGSPRHLRDIVLGVVRDGQLLRIG
APEVDAIEASDRLLYIRQVGR"
gene complement(3573731..3577036)
/locus_tag="Rv3201c"
CDS complement(3573731..3577036)
/codon_start=1
/transl_table=11
/locus_tag="Rv3201c"
/product="Probable ATP-dependent DNA helicase"
/note="Rv3201c, (MTV014.45c), len: 1101 aa. Probable
ATP-dependent DNA helicase, similar to others e.g.
Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222
aa),FASTA scores: opt: 1209, E(): 5.4e-63, (38.45%
identity in 1199 aa overlap);
P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from
Mycobacterium tuberculosis (771 aa), FASTA scores: opt:
403, E(): 6.5e-16, (28.15% identity in 717 aa overlap);
Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159
aa),FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity
in 1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp.
(512 aa; fragment), FASTA scores: opt: 290, E(): 2e-09,
(27.95% identity in 479 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3201c"
/db_xref="EnsemblGenomes-Tr:CCP46016"
/db_xref="GOA:O53347"
/db_xref="InterPro:IPR000212"
/db_xref="InterPro:IPR011335"
/db_xref="InterPro:IPR014016"
/db_xref="InterPro:IPR014017"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR034739"
/db_xref="InterPro:IPR038726"
/db_xref="UniProtKB/TrEMBL:O53347"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46016.1"
/translation="MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAG
AGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGIGLGC
GDPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDTRLLSETELWQLAFDVVSGYDGVLC
TDKSPAAVTSIVVRLWGQLGEHLVDTRALRDTHVELERLVHALPAGRYQRDRGPSQWL
LRMLATQTQRAELVPLLDALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYR
VVLLDEYQDTGHAQRVVLSSLFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTT
DFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRALRPRPDAPPGAVR
CALLPDVQAEREWIADHLRMRYQRAEADGVKPPTAAVLVRRNADAAAIADTLRARGIP
AEVVGLAGLLSIPEVAEVVAMLRLVADPTAGAAAMRVLTGPRWRLGARDLAALWRRAL
TLSGESPSTASPESIAMAASADADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSA
LRGRLGHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAERASA
RSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVHAAKGLEWQVVAVAHLS
RGVFPSTVSRSSWLTDPAELPPLLRGDRASAGAHGIPVLDTSAVADRKQLSDKISEHR
RLLDRRRVDEERRLLYVAVTRAEDTLLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSA
AAGDPCGVVEQWASAPAGDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSA
DLPGSTTDIDHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGD
PVGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADREVGDPEE
LAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAVFVDPDGGATVVDWKTGK
PPHGPAAMRQAAVQLAVYRLAWAALRGCPTSSVRTAFYYVRSGITVVPDELPAPGELA
MLLTDCAGRRSDT"
gene complement(3577033..3580200)
/locus_tag="Rv3202c"
CDS complement(3577033..3580200)
/codon_start=1
/transl_table=11
/locus_tag="Rv3202c"
/product="Possible ATP-dependent DNA helicase"
/note="Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa.
Possible ATP-dependent DNA helicase, showing some
similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 putative
ATP-dependent DNA helicase from Streptomyces coelicolor
(1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5%
identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 mismatch
repair protein MUTU (DNA helicase II) from Pseudomonas
aeruginosa (728 aa), FASTA scores: opt: 239, E():
7.3e-06,(23.8% identity in 677 aa overlap) (no similarity
in C-terminal part for this one); etc. C-terminal region
similar to Q9FDU2|ORF3 ORF3 protein (fragment) from
Streptomyces griseus (551 aa), FASTA scores: opt: 800,
E(): 1.7e-37, (36.2% identity in 525 aa overlap); and
Q9ZG15 hypothetical 35.5 KDA protein from Rhodococcus
erythropolis (323 aa), FASTA scores: opt: 232, E():
9.7e-06, (28.55% identity in 266 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3202c"
/db_xref="EnsemblGenomes-Tr:CCP46017"
/db_xref="GOA:O53348"
/db_xref="InterPro:IPR000212"
/db_xref="InterPro:IPR013986"
/db_xref="InterPro:IPR014016"
/db_xref="InterPro:IPR014017"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR034739"
/db_xref="InterPro:IPR038726"
/db_xref="UniProtKB/TrEMBL:O53348"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46017.1"
/translation="MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLVEAAVAHIG
AGTDPESVLLLTGSGRMGMRARSALTTALLRSRTNGPCRAAIREPVVRTVHSYAYAVL
RKAAQRAGDALPRLLTSAEQDAIIRELLAGDAEDGPAATTTWPAHLRPALTTAGFATE
LRNLLARCAERGLDPLELQQLGRRRGRPEWIAAGQFAQRYEQVMLLRGAVGLAAPQAT
APALSAAELVGAALEAFAVDPELLAAERARVRTLLVDDAQQLDPQAARLVRMLAAGTE
LALIAGDPNQAVFGFRGGEPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGI
ARRLPGRSVGRRIEGTGTEVGSVTVRLAGSAHAEAAMIADALRRAHLIDGVPWSQMAV
IVRSVPRAVRLPRALAAAGVPVAPPAVGGPLSAEPAVRALLTVLEATADGLDGDQALL
LLTGPIGGVDPVSLRQLRRTLQRARPGQTSRKFGDLLVEVLGGDAPPSGPGSRALRRV
RAVLTAAARCHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAAVQATRDLET
VTALFDITDHYVSRTSGASLRGLVEHVTALQLPVVRPEPAAPTEQVMVLSAHAALGHE
WDLVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTKDASMRAPLLAEERRLLVTAM
GRARRRLLVTAVDSDAGGGGHEAVLPSAFFFEIAQWADGDGEPVAMQPVSAPRVLSAA
AVVGRLRVVVCAPACAVDDADRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLC
DSDDLVTLTPSTLQALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRSESQL
LAELDRVWGHLPFGAQWYSANELARHRAMIQAFVQWRAQSRSELTEVGVEVDIDGALE
DGSGQARKIRLRGRADRLERDPAGRLVIVDIKTGKTPVSKDDAQQHAQLAMYQLAVAE
GLVRAGDEPGGARLVYVGKSGAAGVAERKQDPLTPAARDEWRNLVRQLAAATAGPQFI
ARRNDGCTHCPLRPGCPAHVRGSAP"
gene 3580638..3581312
/gene="lipV"
/locus_tag="Rv3203"
CDS 3580638..3581312
/codon_start=1
/transl_table=11
/gene="lipV"
/locus_tag="Rv3203"
/product="Possible lipase LipV"
/note="Rv3203, (MTCY07D11.23c), len: 224 aa. Possible
lipV,hydrolase lipase, showing some similarity to other
lipases e.g. Q9JSN0|NMA2216 putative hydrolase from
Neisseria meningitidis (serogroup A) (312 aa), FASTA
scores: opt: 192, E(): 0.00016, (45.2% identity in 73 aa
overlap); Q9RK95|SCF1.09 putative hydrolase from
Streptomyces coelicolor (258 aa), FASTA scores: opt: 188,
E(): 0.00024,(30.1% identity in 226 aa overlap);
Q9KZC3|SC6F7.19c putative lipase from Streptomyces
coelicolor (269 aa),FASTA scores: opt: 179, E(): 0.00086,
(36.35% identity in 121 aa overlap); etc. Equivalent to
AAK47641 Hydrolase,alpha/beta hydrolase family from
Mycobacterium tuberculosis strain CDC1551 (261 aa) but
shorter 37 aa. Contains serine active site signature of
lipases (PS00120)."
/db_xref="EnsemblGenomes-Gn:Rv3203"
/db_xref="EnsemblGenomes-Tr:CCP46018"
/db_xref="GOA:L0TC47"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:L0TC47"
/inference="protein motif:PROSITE:PS00120"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46018.1"
/translation="MPEIPIAAPDLLGHGRSPWAAPWTIDANVSALAALLDNQGDGPV
VVVGHSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDAMLASPDYLDPAE
ARAEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRISLPAMVCYWSELARDIVLPP
VGTATTLVRAVRASPAYVSDQLLAALDKRLGADFELLDFDCGHMVPQAKPTEVAAVIR
SRLGPR"
gene 3581315..3581620
/locus_tag="Rv3204"
CDS 3581315..3581620
/codon_start=1
/transl_table=11
/locus_tag="Rv3204"
/product="Possible DNA-methyltransferase (modification
methylase)"
/note="Rv3204, (MTCY07D11.22c), len: 101 aa. Possible DNA
methyltransferase, similar to many hypothetical bacteriel
proteins and methyltransferases e.g. Q9KT40|VC1065
methylated-DNA--protein-cysteine methyltransferase-related
protein from Vibrio cholerae (100 aa), FASTA scores: opt:
170, E(): 2.8e-05, (34.35% identity in 99 aa overlap);
Q9UTN9|SPAC1250.04c putative methyltransferase from
Schizosaccharomyces pombe (Fission yeast) (108 aa), FASTA
scores: opt: 161, E(): 0.00013, (36.65% identity in 101 aa
overlap); Q9YDF4|APE0959 175 AA long hypothetical
methylated-DNA--protein-cysteine methyltransferase from
Aeropyrum pernix (175 aa), FASTA scores: opt: 144, E():
0.003, (37.95% identity in 87 aa overlap); Q50855 putative
methylguanine-DNA methyltransferase from Myxococcus
xanthus (147 aa), FASTA scores: opt: 141, E(): 0.0041,
(37.65% identity in 93 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3204"
/db_xref="EnsemblGenomes-Tr:CCP46019"
/db_xref="GOA:O05862"
/db_xref="InterPro:IPR014048"
/db_xref="InterPro:IPR036217"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:O05862"
/protein_id="CCP46019.1"
/translation="MAPVTDEQVELVRSLVAAIPLGRVSTYGDIAALTGLSSPRIVGW
IMRTDSSDLPWHRVIRASGRPAQHLATRQLELLRAEGVLSVDGRVALSEIRYEFPPG"
gene complement(3581627..3582505)
/locus_tag="Rv3205c"
CDS complement(3581627..3582505)
/codon_start=1
/transl_table=11
/locus_tag="Rv3205c"
/product="Conserved protein"
/note="Rv3205c, (MTCY07D11.21), len: 292 aa. Conserved
protein, highly similar to Q9CCG7|ML0818 hypothetical
protein from Mycobacterium leprae (297 aa), FASTA scores:
opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3205c"
/db_xref="EnsemblGenomes-Tr:CCP46020"
/db_xref="GOA:O05861"
/db_xref="InterPro:IPR013402"
/db_xref="UniProtKB/TrEMBL:O05861"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46020.1"
/translation="MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGE
VVLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPR
HDEVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGV
PTAPPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYW
RPASWAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAE
AFPGLAHTAALVRLVL"
gene complement(3582532..3583710)
/gene="moeB1"
/gene_synonym="moeZ"
/locus_tag="Rv3206c"
CDS complement(3582532..3583710)
/codon_start=1
/transl_table=11
/gene="moeB1"
/gene_synonym="moeZ"
/locus_tag="Rv3206c"
/product="Probable molybdenum cofactor biosynthesis
protein MoeB1 (MPT-synthase sulfurylase) (molybdopterin
synthase sulphurylase)"
/note="Rv3206c, (MTCY07D11.20), len: 392 aa. Probable
moeB1, molybdopterin cofactor biosynthesis
protein,equivalent to Q9CCG8|MOEZ|ML0817 protein probably
involved in molybdopterin biosynthesis from Mycobacterium
leprae (395 aa), FASTA scores: opt: 2285, E(): 3.3e-130,
(86.45% identity in 391 aa overlap.) Very similar to
members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02
putative sulfurylase from Streptomyces coelicolor (392
aa), FASTA scores: opt: 1776, E(): 1.4e-99, (65.3%
identity in 395 aa overlap); Q9XC37|PDTORFF MOEB-like
protein (putative sulfurylase) from Pseudomonas stutzeri
(Pseudomonas perfectomarina) (391 aa), FASTA scores: opt:
1526, E(): 1.5e-84, (59.1% identity in 391 aa overlap);
O54307|MPT|MOEB MPT-synthase sulfurylase from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(391 aa), FASTA scores: opt: 1309, E(): 1.8e-71, (52.95%
identity in 387 aa overlap); P74344|MOEB|SLL1536
molybdopterin biosynthesis MOEB protein from Synechocystis
sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1308,
E(): 2e-71, (50.65% identity in 397 aa overlap); etc. Also
highly similar to O05792|MOEB2|Rv3116|MTCY164.26 putative
molybdenum cofactor biosynthesis protein from
Mycobacterium tuberculosis (389 aa), FASTA scores: opt:
1440, E(): 2.3e-79, (57.25% identity in 386 aa overlap).
Has hydrophobic segment from ~45-71. Belongs to the
HesA/MoeB/ThiF FAMILY. Note that previously known as moeZ.
Thought to be differentially expressed within host cells
(see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv3206c"
/db_xref="EnsemblGenomes-Tr:CCP46021"
/db_xref="GOA:P9WMN7"
/db_xref="InterPro:IPR000594"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR035985"
/db_xref="InterPro:IPR036873"
/db_xref="UniProtKB/Swiss-Prot:P9WMN7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46021.1"
/translation="MSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNAR
VLVIGAGGLGAPTLLYLAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSAR
DSIVAINPLIRVRLHELRLAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPY
VWGSIYRFEGQASVFWEDAPDGLGVNYRDLYPEPPPPGMVPSCAEGGVLGIICASVAS
VMGTEAIKLITGIGETLLGRLLVYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVV
ADDAAQAAKGSTITPRELRDWLDSGRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSG
EGLAKLPQDRTAVLYCKTGVRSAEALAAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY
"
gene complement(3583801..3584658)
/locus_tag="Rv3207c"
CDS complement(3583801..3584658)
/codon_start=1
/transl_table=11
/locus_tag="Rv3207c"
/product="Conserved protein"
/note="Rv3207c, (MTCY07D11.19), len: 285 aa. Conserved
protein, highly similar but shorter (57 aa) to
Q9CCG9|ML0816 hypothetical protein from Mycobacterium
leprae (341 aa), FASTA scores: opt: 1676, E():
9.7e-96,(81.0% identity in 284 aa overlap). Also similar
to C-terminus of Q9FBI6|SCP8.36 hypothetical protein from
Streptomyces coelicolor (559 aa), FASTA scores: opt:
426,E(): 8.4e-19, (37.35% identity in 281 aa overlap); and
similar to other hypothetical proteins (generally membrane
proteins) e.g. Q9K456|SC2H12.28C putative membrane protein
from Streptomyces coelicolor (314 aa), FASTA scores: opt:
341, E(): 8.8e-14, (29.75% identity in 296 aa overlap).
Contains neutral zinc metallopeptidases, zinc-binding
region signature (PS00142)."
/db_xref="EnsemblGenomes-Gn:Rv3207c"
/db_xref="EnsemblGenomes-Tr:CCP46022"
/db_xref="GOA:O05859"
/db_xref="InterPro:IPR006026"
/db_xref="InterPro:IPR022603"
/db_xref="InterPro:IPR024079"
/db_xref="UniProtKB/TrEMBL:O05859"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46022.1"
/translation="MSTYGWRAYALPVLMVLTTVVVYQTVTGTSTPRPAAAQTVRDSP
AIGVVGTAILDAPPRGLAVFDANLPAGTLPDGGPFTEAGDKTWRVVPGTTPQVGQGTV
KVFRYTVEIENGLDPTMYGGDNAFAQMVDQTLTNPKGWTHNPQFAFVRIDSGKPDFRI
SLVSPTTVRGGCGYEFRLETSCYNPSFGGMDRQSRVFINEARWVRGAVPFEGDVGSYR
QYVINHEVGHAIGYLRHEPCDQQGGLAPVMMQQTFSTSNDDAAKFDPDFVKADGKTCR
FNPWPYPIP"
gene 3585004..3585690
/locus_tag="Rv3208"
CDS 3585004..3585690
/codon_start=1
/transl_table=11
/locus_tag="Rv3208"
/product="Probable transcriptional regulatory protein
(probably TetR-family)"
/note="Rv3208, (MTCY07D11.18c), len: 228 aa. Probable
transcriptional regulator, TetR family, equivalent to
Q9CCH0|ML0815 putative TetR-family transcriptional
regulator from Mycobacterium leprae (228 aa), FASTA
scores: opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa
overlap). Also highly similar to Q9FBI8|SCP8.33c putative
TetR-family transcriptional regulator from Streptomyces
coelicolor (213 aa), FASTA scores: opt: 629, E():
4e-34,(45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R
(fragment) from Streptomyces coelicolor A3(2) (149
aa),FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity
in 147 aa overlap); Q9K3T5|SCE66.08 putative TetR-family
transcriptional regulator from Streptomyces coelicolor
(225 aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15%
identity in 212 aa overlap); Q9RYK4|DRA0308
transcriptional regulator, TetR family from Deinococcus
radiodurans (239 aa), FASTA scores: opt: 290, E():
6.5e-12, (30.5% identity in 223 aa overlap); etc. And also
similar to Mycobacterium tuberculosis proteins
P96381|Rv1019|MTCY10G2.30c hypothetical 21.7 KDA protein
(197 aa), FASTA scores: opt: 356, E(): 2.7e-16, (34.4%
identity in 189 aa overlap); MTV034_4; MTY07A7A_3;
MTV032_1; MTCY07A7_12; etc. Contains probable
helix-turn-helix motif at aa 60-81 (Score 1517,+4.35 SD).
Similar to the TetR/AcrR family of transcriptional
regulators."
/db_xref="EnsemblGenomes-Gn:Rv3208"
/db_xref="EnsemblGenomes-Tr:CCP46023"
/db_xref="GOA:O05858"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:O05858"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46023.1"
/translation="MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQL
LVVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGV
HQALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCI
DAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWG
GLSHVPLTRS"
gene complement(3585677..3585949)
/gene="TB9.4"
/locus_tag="Rv3208A"
CDS complement(3585677..3585949)
/codon_start=1
/transl_table=11
/gene="TB9.4"
/locus_tag="Rv3208A"
/product="Conserved protein TB9.4"
/note="Rv3208A, len: 90 aa. TB9.4, conserved protein (see
citations below), equivalent to Q9CCH1|ML0814 hypothetical
protein from Mycobacterium leprae (82 aa), FASTA scores:
opt: 411, E(): 1.8e-22, (81.0% identity in 79 aa overlap).
Also similar, but shorter in N-terminus, to
Q9FBI9|SCP8.32c putative ATP-binding protein from
Streptomyces coelicolor (94 aa), FASTA scores: opt: 246,
E(): 8.1e-11, (53.4% identity in 73 aa overlap); Q9DGP6
(alias Q9DGP4) glutamate decarboxylase 67 KDA isoform
(fragment) from Alepocephalus bairdii (182 aa), FASTA
scores: opt: 100, E(): 2.6, (35.3% identity in 85 aa
overlap). Corresponds to Statens Serum Institute antigen,
CYP10 TB9.4. Has N-terminal sequence,vevkigitdsprelv."
/db_xref="EnsemblGenomes-Gn:Rv3208A"
/db_xref="EnsemblGenomes-Tr:CCP46024"
/db_xref="InterPro:IPR021456"
/db_xref="UniProtKB/TrEMBL:Q6MWZ8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46024.1"
/translation="MEVKIGITDSPRELVFSSAQTPSEVEELVSNALRDDSGLLTLTD
ERGRRFLIHTARIAYVEIGVADARRVGFGVGVDAAAGSAGKVATSG"
gene 3586274..3586834
/locus_tag="Rv3209"
CDS 3586274..3586834
/codon_start=1
/transl_table=11
/locus_tag="Rv3209"
/product="Conserved hypothetical threonine and proline
rich protein"
/note="Rv3209, (MTCY07D11.17c), len: 186 aa. Conserved
hypothetical thr-, pro-rich protein, equivalent (but
shorter 36 aa in N-terminus) to Q9CCH2|ML0813 putative
membrane protein from Mycobacterium leprae (195 aa), FASTA
scores: opt: 508, E(): 1.4e-15, (58.4% identity in 185 aa
overlap). Also some similarity with
Q10390|MMS3_MYCTU|MMPS3|Rv2198c|MT2254|MTCY190.09c
probable conserved transmembrane transport protein from M.
tuberculosis (299 aa), FASTA scores: opt: 339, E():
3.7e-08, (35.0% identity in 180 aa overlap); and
Q9CCE9|MMPS3|ML0877 putative membrane protein from
Mycobacterium leprae (293 aa), FASTA scores: opt: 272,
E(): 2.8e-05, (36.4% identity in 173 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3209"
/db_xref="EnsemblGenomes-Tr:CCP46025"
/db_xref="GOA:O05857"
/db_xref="InterPro:IPR008693"
/db_xref="InterPro:IPR038468"
/db_xref="UniProtKB/TrEMBL:O05857"
/protein_id="CCP46025.1"
/translation="MALGAVATAVIINSGDSTSTKAIVGAPAPRTVISTSPRPTAPTS
TSPHPSPSTLRPQLPPETVTTVAPPGTGPTTVPTRTPTAAPPQTAVPPPAPLNPRTVV
YRVTGTKQLFDLVNVVYTDARGFPVTDFNVSLPWTKMVVLNPGVQTESVVATSLYSRL
NCSIVNTGAQTVVASTNNAIIATCTR"
gene complement(3586844..3587539)
/locus_tag="Rv3210c"
CDS complement(3586844..3587539)
/codon_start=1
/transl_table=11
/locus_tag="Rv3210c"
/product="Conserved protein"
/note="Rv3210c, (MTCY07D11.16), len: 231 aa. Conserved
protein, similar (but N-terminus shorter) to
Q9FBJ1|SCP8.30 conserved hypothetical protein from
Streptomyces coelicolor (260 aa), FASTA scores: opt: 599,
E(): 1.1e-30, (42.5% identity in 233 aa overlap); and some
similarity to Q9RRV1|DR2384 phenylacetic acid degradation
protein PAAC from Deinococcus radiodurans (263 aa), FASTA
scores: opt: 129, E(): 0.43, (27.9% identity in 172 aa
overlap); and Q9F621 FLGK protein from Rhizobium meliloti
(Sinorhizobium meliloti) (472 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3210c"
/db_xref="EnsemblGenomes-Tr:CCP46026"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012347"
/db_xref="UniProtKB/TrEMBL:O05856"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46026.1"
/translation="MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLT
DEARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLT
TPSTWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAA
VTASGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQ
QTHDQRMRELGLS"
gene 3587798..3589381
/gene="rhlE"
/locus_tag="Rv3211"
CDS 3587798..3589381
/codon_start=1
/transl_table=11
/gene="rhlE"
/locus_tag="Rv3211"
/product="Probable ATP-dependent RNA helicase RhlE"
/note="Rv3211, (MTCY07D11.15c), len: 527 aa. Probable
rhlE,ATP-dependent RNA helicase, equivalent (but shorter
22 aa) to Q9CCH3|RHLE|ML0811 putative ATP-dependent RNA
helicase from Mycobacterium leprae (544 aa), FASTA scores:
opt: 2497, E(): 8.7e-131, (74.75% identity in 531 aa
overlap). Also highly similar to other RNA helicases e.g.
Q9FBJ2|SCP8.29c from Streptomyces coelicolor (879
aa),FASTA scores: opt: 1458, E(): 3.6e-73, (52.5% identity
in 522 aa overlap); Q9DF36 from Xenopus laevis (African
clawed frog) (800 aa), FASTA scores: opt: 792, E():
2.3e-36,(37.15% identity in 385 aa overlap);
Q99Z38|dead|SPY1415 from Streptococcus pyogenes (759 aa),
FASTA scores: opt: 779, E(): 1.1e-35, (37.1% identity in
380 aa overlap); P33906|dead|CSDA from Klebsiella
pneumoniae (642 aa), FASTA scores: opt: 768, E(): 4e-35,
(43.4% identity in 387 aa overlap); etc. Contains
ATP/GTP-binding site motif A (PS00017) and dead-box
subfamily ATP-dependent helicases signature (PS00039).
Similar to dead/DEAH box helicase family and similar to
helicase C-terminal domain."
/db_xref="EnsemblGenomes-Gn:Rv3211"
/db_xref="EnsemblGenomes-Tr:CCP46027"
/db_xref="GOA:O05855"
/db_xref="InterPro:IPR000629"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR014014"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O05855"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00039"
/protein_id="CCP46027.1"
/translation="MTAVKHTTESTFAKLGVRDEIVRALGEEGIKRPFAIQELTLPLA
LDGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGAPRALVVVPTRELCLQVTD
DLATAGKYLTAGPDTDDAAAVRRRLSVVSIYGGRPYEPQIEALRAGADVVVGTPGRLL
DLCQQGHLQLGGLSVLVLDEADEMLDLGFLPDIERILRQIPADRQSMLFSATMPDPII
TLARTFMVRPTHIRAEAPHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIF
TRTKRTAQKVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGI
DIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSMIDQALGLG
SPDPAETYSNSPHLYAELAIPATAGGTVGPARKSQGRRRDTDCDGQKTAQHARNTPRR
RRTRGGKPVTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVVSGSRSGNGEAARRR
RRRRRRPTHAQDGFAARAN"
gene 3589394..3590617
/locus_tag="Rv3212"
CDS 3589394..3590617
/codon_start=1
/transl_table=11
/locus_tag="Rv3212"
/product="Conserved alanine valine rich protein"
/note="Rv3212, (MTCY07D11.14c), len: 407 aa. Conserved
ala-, val-rich protein, equivalent to Q9CCH4|ML0810
putative membrane protein from Mycobacterium leprae (407
aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85%
identity in 407 aa overlap). Weak similarity to several
eukaryotic transcription factors e.g.
P08393|ICP0_HSV11|ICP0|IE110 trans-acting transcriptional
protein from Herpes simplex virus (type 1 / strain 17)
(775 aa), FASTA scores: opt: 115, E(): 2, (26.9% identity
in 334 aa overlap). A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004).
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3212"
/db_xref="EnsemblGenomes-Tr:CCP46028"
/db_xref="GOA:O05854"
/db_xref="InterPro:IPR011047"
/db_xref="UniProtKB/TrEMBL:O05854"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46028.1"
/translation="MVKPERRTKTDIAAAATIAVVVAVAASLIWWTSDARATISRPAA
VAVPTPAPAREVPTSLKQLWTAASPATRVPVVVGGTVATGDGRQVDGRDPATGESLWS
YARDTDLCGVTWVYHYAVAVYRYDRGCGQVSTIDGSTGRRGAARSGYADPRVRLFSDG
TTVLSAGDTRLELWRSDMVRMLAYGEIDARVKPSNRGLQSGCTLESAAASSAAVSVLE
ACTNQADLRLVLLRPGKEDDEPIQRIVPEPGVRPGSGARVLVVSQNNTAVYLPARSGA
QPRVDVIDETGATVSSTLLAKPPSTSAVASRTGNLVTWWTGDALLVFDAGNLTQRYTI
AAGETTAPVGPGVMMAGQLLVPVTGGIGVYDPVSGANNRYIPVTRPPSTSAVIPAVSG
SRVIEQRGDTLVALG"
gene complement(3590692..3591492)
/locus_tag="Rv3213c"
CDS complement(3590692..3591492)
/codon_start=1
/transl_table=11
/locus_tag="Rv3213c"
/product="Possible SOJ/para-related protein"
/note="Rv3213c, (MTCY07D11.13), len: 266 aa. Possible
soj/parA-related protein, very similar in particular to
Soj/ParA proteins (and relatives) from Bacillus subtilis
that inhibit the initiation of sporulation by preventing
phosphorylation of Spo0A (see Quisel & Grossman 2000) e.g.
Q9S228|SCI51.12c from Streptomyces coelicolor (340
aa),FASTA scores: opt: 746, E(): 1.6e-40, (48.2% identity
in 249 aa overlap); Q9HT11|SOJ|PA5563 from Pseudomonas
aeruginosa (262 aa), FASTA scores: opt: 649, E():
2.1e-34,(42.2% identity in 256 aa overlap); Q9PB62|XF2282
from Xylella fastidiosa (264 aa), FASTA scores: opt: 624,
E(): 8.3e-33, (42.25% identity in 251 aa overlap);
Q9K5N0|SOJ_BACHD|SOJ|BH4058 from Bacillus halodurans (253
aa), FASTA scores: opt: 621, E(): 1.2e-32, (41.55%
identity in 248 aa overlap); P37522|SOJ_BACSU (253 aa),
FASTA scores: opt: 620, E(): 1.4e-32, (41.65% identity in
245; etc. Also similar to various mycobacterial proteins:
U00021_10 from Mycobacterium leprae, MTCI125_29 from
Mycobacterium tuberculosis, MLCB1351_6 from Mycobacterium
leprae, MTV028_9c|Rv3918c|para probable chromosome
partitioning protein from Mycobacterium
tuberculosis,MSGDNAB_18 from Mycobacterium leprae. Seems
to belong to the para family."
/db_xref="EnsemblGenomes-Gn:Rv3213c"
/db_xref="EnsemblGenomes-Tr:CCP46029"
/db_xref="GOA:O05853"
/db_xref="InterPro:IPR025669"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O05853"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46029.1"
/translation="MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQ
GCLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMR
AGREYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADKAIVPLQCEMLAHRGVG
QFLRTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTV
RFAEASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL"
repeat_region complement(3591493..3591569)
/note="77 bp Mycobacterial Interspersed Repetitive
Unit,Class I"
gene 3591646..3592257
/gene="gpm2"
/gene_synonym="entD"
/locus_tag="Rv3214"
CDS 3591646..3592257
/codon_start=1
/transl_table=11
/gene="gpm2"
/gene_synonym="entD"
/locus_tag="Rv3214"
/product="Possible phosphoglycerate mutase Gpm2
(phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)"
/note="Rv3214, (MTCY07D11.12c), len: 203 aa. Possible
gpm2,phosphoglycerate mutase, similar to many mutases
especially phosphoglycerate mutases e.g. Q9F3H5|2SCC13.14c
putative mutase from Streptomyces coelicolor (198 aa),
FASTA scores: opt: 487, E(): 4.4e-25, (42.25% identity in
194 aa overlap); BAB49378|MLL2186 probable
phosphoglycerate mutase from Rhizobium loti (Mesorhizobium
loti) (193 aa), FASTA scores: opt: 423, E(): 7e-21, (41.2%
identity in 182 aa overlap); Q9RKV8|SC9G1.08c putative
phosphatase from Streptomyces coelicolor (199 aa), FASTA
scores: opt: 419,E(): 1.3e-20, (41.1% identity in 185 aa
overlap); Q9RDL0|SCC123.14c putative phosphoglycerate
mutase from Streptomyces coelicolor (223 aa), FASTA
scores: opt: 240,E(): 8.8e-09, (36.9% identity in 168 aa
overlap); Q9X194|TM1374 phosphoglycerate mutase from
Thermotoga maritima (201 aa), FASTA scores: opt: 218, E():
2.3e-07,(33.15% identity in 202 aa overlap); etc. But
N-terminus also similar to Q9CCH5|ENTC|ML0808 putative
isochorismate synthase from Mycobacterium leprae (577 aa),
FASTA scores: opt: 346, E(): 2.1e-15, (55.05% identity in
109 aa overlap). N-terminus shows also some similarity
with other M. tuberculosis proteins e.g. MTCY427.09c;
MTCY20G9.15; MTCY428.28. Equivalent to AAK47652 from
Mycobacterium tuberculosis strain CDC1551 (228 aa) but
shorter 25 aa. Note that previously known as entD."
/db_xref="EnsemblGenomes-Gn:Rv3214"
/db_xref="EnsemblGenomes-Tr:CCP46030"
/db_xref="GOA:Q6MWZ7"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="PDB:2A6P"
/db_xref="UniProtKB/Swiss-Prot:Q6MWZ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46030.1"
/translation="MGVRNHRLLLLRHGETAWSTLGRHTGGTEVELTDTGRTQAELAG
QLLGELELDDPIVICSPRRRTLDTAKLAGLTVNEVTGLLAEWDYGSYEGLTTPQIRES
EPDWLVWTHGCPAGESVAQVNDRADSAVALALEHMSSRDVLFVSHGHFSRAVITRWVQ
LPLAEGSRFAMPTASIGICGFEHGVRQLAVLGLTGHPQPIAAG"
gene 3592254..3593372
/gene="entC"
/locus_tag="Rv3215"
CDS 3592254..3593372
/codon_start=1
/transl_table=11
/gene="entC"
/locus_tag="Rv3215"
/product="Probable isochorismate synthase EntC
(isochorismate hydroxymutase) (enterochelin biosynthesis)"
/note="Rv3215, (MTCY07D11.11c), len: 372 aa. Probable
entC,isochorismate synthase, equivalent to
Q9CCH5|ENTC|ML0808 putative isochorismate synthase from
Mycobacterium leprae (577 aa), FASTA scores: opt: 1817,
E(): 5.5e-105, (73.5% identity in 366 aa overlap). Also
similar to others e.g. Q9F639|MXCD protein involved in
myxochelin-type iron chelator biosynthesis (see citation
below) from Stigmatella aurantiaca (408 aa), FASTA scores:
opt: 893, E(): 6.2e-48,(41.6% identity in 382 aa overlap);
P45744|DHBC_BACSU isochorismate synthase from Bacillus
subtilis (398 aa),FASTA scores: opt: 883, E(): 2.5e-47,
(40.45% identity in 393 aa overlap); Q9KI93|CSBC
isochorismate synthase (fragment) from Azotobacter
vinelandii (361 aa), FASTA scores: opt: 794, E(): 7.6e-42,
(45.65% identity in 298 aa overlap); and the two
Escherichia coli proteins AAG54928|ENTC (alias
BAB34055|ECS0632) isochorismate hydroxymutase 2 from
Escherichia coli strain O157:H7 (391 aa), FASTA scores:
opt: 744, E(): 1e-38, (38.8% identity in 340 aa overlap);
P10377|ENTC|B0593 isochorismate synthase from Escherichia
coli strain K12 (391 aa), FASTA scores: opt: 744, E():
1e-38, (38.8% identity in 340 aa overlap); etc. Stronger
similarity to Escherichia coli entC. Also similar to
MTCY253.35."
/db_xref="EnsemblGenomes-Gn:Rv3215"
/db_xref="EnsemblGenomes-Tr:CCP46031"
/db_xref="GOA:P9WFW9"
/db_xref="InterPro:IPR004561"
/db_xref="InterPro:IPR005801"
/db_xref="InterPro:IPR015890"
/db_xref="UniProtKB/Swiss-Prot:P9WFW9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46031.1"
/translation="MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRS
GTAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTR
IGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSA
GNDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRH
EHQLVVDTMRVALEPLCEDLTIPAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALA
LHPTPAVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRR
AALAHAGGGIVAESDPDDELEETTTKFATILTALGVEQ"
gene order(3593369..3593437,3593439..3593852)
/pseudo
/locus_tag="Rv3216"
CDS join(3593369..3593437,3593439..3593852)
/codon_start=1
/transl_table=11
/locus_tag="Rv3216"
/product="GCN5-related N-acetyltransferase, pseudogene"
/note="Rv3216, (MTCY07D11.10c), len: 160 aa.
Acetyltransferase (2.3.1.-), contains GNAT domain
(Gcn5-related N-acetyltransferase. See Vetting et al.
2005), probably pseudogene as appears frameshifted due to
1bp insertion at position 3593438. Frameshift present in
all sequenced tubercle bacilli. Start changed since first
submission, extended by 50aa. Similar to many
acetyltransferases e.g. Q9AB32|CC0402 acetyltransferase
(GNAT family) from Caulobacter crescentus (159 aa), FASTA
scores: opt: 325, E(): 3.8e-17, (45.65% identity in 103 aa
overlap); P79081|ATS1 putative acetyltransferase ATS1 from
Schizosaccharomyces pombe (Fission yeast) (168 aa), FASTA
scores: opt: 313, E(): 3.1e-16, (47.6% identity in 105 aa
overlap)."
/db_xref="PSEUDO:CCP46032.1"
/pseudogene="unknown"
gene complement(3593804..3594235)
/locus_tag="Rv3217c"
CDS complement(3593804..3594235)
/codon_start=1
/transl_table=11
/locus_tag="Rv3217c"
/product="Probable conserved integral membrane protein"
/note="Rv3217c, (MTCY07D11.09), len: 143 aa. Probable
conserved integral membrane protein, equivalent (highly
similar but shorter 30 aa) to Q9CCH6|ML0806 putative
membrane protein from Mycobacterium leprae (173 aa). Also
similar to others e.g. Q9F3L9|2SC7G11.04 putative integral
membrane protein from Streptomyces coelicolor (152
aa),FASTA scores: opt: 177, E(): 0.00024, (33.8% identity
in 136 aa overlap). And shows similarity to
O34238|MVIN|VC0680 virulence factor MVIN homolog from
Vibrio (525 aa), FASTA scores: opt: 126, E(): 0.97, (30.9%
identity in 68 aa overlap). First GTG taken. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv3217c"
/db_xref="EnsemblGenomes-Tr:CCP46033"
/db_xref="GOA:O05849"
/db_xref="UniProtKB/TrEMBL:O05849"
/protein_id="CCP46033.1"
/translation="MPVRAPAAVRGAGLIVAVQGGAALVVAAALLVRGLAGADQHIVN
GLGTAGWFVLVGGAVLAAGCRLAVGKLWGRGLAVFAQLLLLPVAWYLIVGSHQPAIGI
PVGIIALGVLVLLFSPPSIRWAAGRDQRGAASAANRGPDSR"
gene 3594468..3595433
/locus_tag="Rv3218"
CDS 3594468..3595433
/codon_start=1
/transl_table=11
/locus_tag="Rv3218"
/product="Conserved protein"
/note="Rv3218, (MTCY07D11.08c), len: 321 aa. Conserved
protein, similar to several hypothetical bacterial
proteins e.g. Q9F3M0|2SC7G11.03c from Streptomyces
coelicolor (322 aa), FASTA scores: opt: 694, E(): 4.2e-35,
(39.95% identity in 328 aa overlap); Q9A0J4|SPY0752 from
Streptomyces pyogenes (340 aa), FASTA scores: opt: 187,
E(): 0.00033,(30.5% identity in 141 aa overlap);
O31502|YERQ from Bacillus subtilis (303 aa), FASTA scores:
opt: 184, E(): 0.00045, (34.15% identity in 126 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3218"
/db_xref="EnsemblGenomes-Tr:CCP46034"
/db_xref="GOA:O05848"
/db_xref="InterPro:IPR001206"
/db_xref="InterPro:IPR016064"
/db_xref="InterPro:IPR017438"
/db_xref="UniProtKB/TrEMBL:O05848"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46034.1"
/translation="MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGT
ELGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLAR
ALGISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVE
AERDKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTY
ANNRPVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVAC
LRVTSMGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI"
gene 3595713..3595967
/gene="whiB1"
/gene_synonym="whmE"
/locus_tag="Rv3219"
CDS 3595713..3595967
/codon_start=1
/transl_table=11
/gene="whiB1"
/gene_synonym="whmE"
/locus_tag="Rv3219"
/product="Transcriptional regulatory protein WhiB-like
WhiB1. Contains [4FE-4S]2+ cluster."
/note="Rv3219, (MTCY07D11.07c), len: 84 aa. WhiB1
(alternate gene name: whmE), WhiB-like regulatory protein
(see Hutter and Dick, 1999), similar to WhiB paralogue of
Streptomyces coelicolor. Equivalent to Q9CCH7|WHIB1|ML0804
putative transcriptional regulator from Mycobacterium
leprae (84 aa), FASTA scores: opt: 580, E():
3.5e-35,(95.25% identity in 84 aa overlap). Highly similar
to several e.g. Q9X952|WBLE developmental regulatory
protein WhiB-paralog from Streptomyces coelicolor (85 aa),
FASTA scores: opt: 477, E(): 9.2e-28, (75.3% identity in
81 aa overlap); Q9AD55|SCP1.95 putative regulatory protein
from Streptomyces coelicolor (102 aa), FASTA scores: opt:
383,E(): 6.1e-21, (60.75% identity in 79 aa overlap);
Q9K4K8|SC5F8.16c from Streptomyces coelicolor (83
aa),FASTA scores: opt: 346, E(): 2.5e-18, (54.75% identity
in 84 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3219"
/db_xref="EnsemblGenomes-Tr:CCP46035"
/db_xref="GOA:P9WF43"
/db_xref="InterPro:IPR003482"
/db_xref="InterPro:IPR034768"
/db_xref="PDB:5OAY"
/db_xref="UniProtKB/Swiss-Prot:P9WF43"
/protein_id="CCP46035.1"
/translation="MDWRHKAVCRDEDPELFFPVGNSGPALAQIADAKLVCNRCPVTT
ECLSWALNTGQDSGVWGGMSEDERRALKRRNARTKARTGV"
gene complement(3596029..3597534)
/locus_tag="Rv3220c"
CDS complement(3596029..3597534)
/codon_start=1
/transl_table=11
/locus_tag="Rv3220c"
/product="Probable two component sensor kinase"
/note="Rv3220c, (MTCY07D11.06), len: 501 aa. Probable
sensor (probably histidine kinase), equivalent to
Q9CCH8|ML0803 putative two-component system sensor kinase
from Mycobacterium leprae (500 aa). Similar to others e.g.
Q9F3M1|2SC7G11.01 putative histidine kinase (fragment)
from Streptomyces coelicolor (372 aa), FASTA scores: opt:
1038,E(): 7.4e-56, (48.95% identity in 380 aa overlap);
Q9A3K5|CC3198 sensor histidine kinase from Caulobacter
crescentus (327 aa), FASTA scores: opt: 311, E():
1.2e-11,(33.35% identity in 201 aa overlap) (similarity
only in C-terminal part for this one); Q9A2T2|CC3474
putative sensor histidine kinase from Caulobacter
crescentus (547 aa); etc. C-terminal half shows similarity
to many sensor proteins, that respond to various stimuli
from Methanobacterium thermoautotrophicum e.g.
O26568|MTH468 sensory transduction histidine kinase (554
aa), FASTA scores: opt: 425, E(): 2.1e-18, (34.0% identity
in 244 aa overlap); O26546|MTH446 sensory transduction
regulatory protein (583 aa), FASTA scores: opt: 380, E():
1.2e-15,(37.15% identity in 202 aa overlap); O26913|MTH823
sensory transduction regulatory protein (677 aa), FASTA
scores: opt: 375, E(): 2.7e-15, (35.4% identity in 195 aa
overlap); etc. Seems similar to other prokaryotic sensory
transduction histidine kinases."
/db_xref="EnsemblGenomes-Gn:Rv3220c"
/db_xref="EnsemblGenomes-Tr:CCP46036"
/db_xref="GOA:P9WGL5"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR011495"
/db_xref="InterPro:IPR022066"
/db_xref="InterPro:IPR035965"
/db_xref="InterPro:IPR036890"
/db_xref="InterPro:IPR038424"
/db_xref="PDB:2YKF"
/db_xref="PDB:2YKH"
/db_xref="UniProtKB/Swiss-Prot:P9WGL5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46036.1"
/translation="MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWV
RRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQN
SCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEG
TFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDA
TRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAI
LIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIE
SVRRVSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLD
SDRATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGF
SLEKSDSLGLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML"
gene complement(3597551..3597766)
/gene="TB7.3"
/locus_tag="Rv3221c"
CDS complement(3597551..3597766)
/codon_start=1
/transl_table=11
/gene="TB7.3"
/locus_tag="Rv3221c"
/product="Biotinylated protein TB7.3"
/note="Rv3221c, (MTCY07D11.05), len: 71 aa.
TB7.3,Biotinylated protein (see citations below),
equivalent (appears to have one additional residue) to
Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3
homolog from Mycobacterium leprae (70 aa), FASTA scores:
opt: 367,E(): 4e-18, (90.0% identity in 70 aa overlap);
Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from
Mycobacterium smegmatis (70 aa), FASTA scores: opt:
341,E(): 2.1e-16, (84.05% identity in 69 aa overlap).
Similar to C-terminal part of various proteins e.g.
Q9HPP8|ACC|VNG1532G biotin carboxylase from Halobacterium
sp. strain NRC-1 (610 aa), FASTA scores: opt: 212, E():
4e-07, (50.0% identity in 68 aa overlap);
Q58628|PYCB_METJA|MJ1231 pyruvate carboxylase subunit B
from Methanococcus jannaschii (567 aa), FASTA scores: opt:
192, E(): 7.8e-06, (44.8% identity in 58 aa overlap);
Q9ZAA7|GCDC glutaconyl-CoA decarboxylase gamma subunit
from Acidaminococcus fermentans (145 aa), FASTA scores:
opt: 184, E(): 8.9e-06, (39.4% identity in 66 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3221c"
/db_xref="EnsemblGenomes-Tr:CCP46037"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR011053"
/db_xref="UniProtKB/Swiss-Prot:P9WPQ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46037.1"
/translation="MAEDVRAEIVASVLEVVVNEGDQIDKGDVVVLLESMKMEIPVLA
EAAGTVSKVAVSVGDVIQAGDLIAVIS"
gene complement(3598051..3598356)
/gene="rshA"
/locus_tag="Rv3221A"
CDS complement(3598051..3598356)
/codon_start=1
/transl_table=11
/gene="rshA"
/locus_tag="Rv3221A"
/product="Anti-sigma factor RshA"
/note="Rv3221A, len: 101 aa. RshA, anti-sigma
factor,similar to Q9XCD7|AAD41811.1 unknown protein from
Mycobacterium smegmatis, linked to sigma factor sigH (see
Fernandes et al., 1999) (101 aa), FASTA scores: opt:
422,E(): 3.4e-22, (64.9% identity in 94 aa overlap); and
to Q9RL96|RsrA anti-sigma factor from Streptomyces
coelicolor (see Kang et al., 1999) (105 aa), FASTA scores:
opt: 163,E(): 0.00016, (32.05% identity in 78 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3221A"
/db_xref="EnsemblGenomes-Tr:CCP46038"
/db_xref="GOA:P9WJ69"
/db_xref="InterPro:IPR014295"
/db_xref="InterPro:IPR024020"
/db_xref="InterPro:IPR027383"
/db_xref="UniProtKB/Swiss-Prot:P9WJ69"
/protein_id="CCP46038.1"
/translation="MSENCGPTDAHADHDDSHGGMGCAEVIAEVWTLLDGECTPETRE
RLRRHLEACPGCLRHYGLEERIKALIGTKCRGDRAPEGLRERLRLEIRRTTIIRGGP"
gene complement(3598353..3598904)
/locus_tag="Rv3222c"
CDS complement(3598353..3598904)
/codon_start=1
/transl_table=11
/locus_tag="Rv3222c"
/product="Conserved hypothetical protein"
/note="Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical
protein, with some similarity to
Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from
Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA
scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa
overlap); Q9S222|SCI51.18 putative transcriptional
regulator from Streptomyces coelicolor (548 aa), FASTA
scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa
overlap); etc. Also some similarity to other hypothetical
Mycobacterium tuberculosis proteins e.g.
O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt:
141, E(): 0.5, (31.2% identity in 170 aa overlap);
AAK45760|MT1497.1 PE_PGRS family protein from strain
CDC1551 (1408 aa), FASTA scores: opt: 137, E(): 2,(31.75%
identity in 148 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3222c"
/db_xref="EnsemblGenomes-Tr:CCP46039"
/db_xref="UniProtKB/TrEMBL:O05844"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46039.1"
/translation="MSSPVSSRRLANLVKESLQGSVLGGVVSDAVLPAVSDDVKPGAG
EDAYRVPVVVAAGSGAVVQVGGLEVGSAAVAGEVADTVAELFVCRPTEPDVGDFVGLA
GGAGDAGQAGQQFGLGVGVRGESFGARRRLALSTVGASGATAGLRKTHDGHHGCQARG
ALTQRRLYIGNPSEITDTRMVHQ"
gene complement(3598901..3599551)
/gene="sigH"
/gene_synonym="rpoE"
/locus_tag="Rv3223c"
CDS complement(3598901..3599551)
/codon_start=1
/transl_table=11
/gene="sigH"
/gene_synonym="rpoE"
/locus_tag="Rv3223c"
/product="Alternative RNA polymerase sigma-E factor
(sigma-24) SigH (RPOE)"
/note="Rv3223c, (MTCY07D11.03), len: 216 aa. SigH
(alternate gene name: rpoE), alternative RNA polymerase
sigma factor (see citations below), similar to many e.g.
Q9XCD8|sigh from Mycobacterium smegmatis (215 aa), FASTA
scores: opt: 1187, E(): 8.1e-69, (87.75% identity in 212
aa overlap); O87834|SIGR from Streptomyces coelicolor (227
aa), FASTA scores: opt: 913, E(): 2.6e-51, (68.8% identity
in 202 aa overlap); O68520|RPOE1 from Myxococcus xanthus
(213 aa), FASTA scores: opt: 452, E(): 6.7e-22, (42.8%
identity in 187 aa overlap);
Q06198|RPSH_PSEAE|ALGU|ALGT|PA0762 from Pseudomonas
aeruginosa (193 aa), FASTA scores: opt: 301, E():
2.7e-12,(29.9% identity in 194 aa overlap); etc.
Equivalent to AAK47662 RNA polymerase sigma-70 factor from
Mycobacterium tuberculosis strain CDC1551 (284 aa), but
shorter 68 aa. Has sigma-70 factors ECF subfamily
signature (PS01063). So belongs to the sigma-70 factor
family, ECF subfamily. Start chosen on basis of
similarity, other potential starts upstream."
/db_xref="EnsemblGenomes-Gn:Rv3223c"
/db_xref="EnsemblGenomes-Tr:CCP46040"
/db_xref="GOA:P9WGH9"
/db_xref="InterPro:IPR000838"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR014293"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039425"
/db_xref="PDB:5ZX2"
/db_xref="PDB:5ZX3"
/db_xref="PDB:6JCX"
/db_xref="PDB:6JCY"
/db_xref="UniProtKB/Swiss-Prot:P9WGH9"
/inference="protein motif:PROSITE:PS01063"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46040.1"
/translation="MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGA
LRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPA
EYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYAD
VEGFPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS"
gene 3599851..3600699
/locus_tag="Rv3224"
CDS 3599851..3600699
/codon_start=1
/transl_table=11
/locus_tag="Rv3224"
/product="Possible iron-regulated short-chain
dehydrogenase/reductase"
/note="Rv3224, (MTCY07D11.02c), len: 282 aa. Probable
iron-regulated oxidoreductase, possible short-chain
dehydrogenase/reductase, highly similar to
BAB49551|MLL2413 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053,
E(): 6.4e-59,(57.95% identity in 276 aa overlap);
Q9AB34|CC0400 short chain dehydrogenase family protein
from Caulobacter crescentus (285 aa), FASTA scores: opt:
1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and
Q9VB10|CG5590 hypothetical protein (similar to the
short-chain dehydrogenases/reductases (SDR) family) from
Drosophila melanogaster (Fruit fly) (412 aa), FASTA
scores: opt: 966,E(): 2.5e-53, (52.15% identity in 278 aa
overlap). Similar to various proteins (principaly
oxidoreductases) e.g. Q18639|C45B11.3 hypothetical protein
(similar to the SDR family) from Caenorhabditis elegans
(293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3%
identity in 271 aa overlap); Q9HZV5|PA2892 probable
short-chain dehydrogenase from Pseudomonas aeruginosa (274
aa), FASTA scores: opt: 847,E(): 5.1e-46, (49.25% identity
in 274 aa overlap); Q9I6V0|PA0182 probable short-chain
dehydrogenase (similar to the SDR family) from Pseudomonas
aeruginosa (250 aa),FASTA scores: opt: 333, E(): 8.3e-14,
(29.8% identity in 245 aa overlap); Q9HY98|PA3511 probable
short-chain dehydrogenase from Pseudomonas aeruginosa (253
aa), FASTA scores: opt: 330, E(): 1.3e-13, (31.2% identity
in 250 aa overlap); etc. Related proteins in Mycobacterium
tuberculosis include MTCY02B10.14, MTCY369.14, and
MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017)
near C-terminus. May be belong to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv3224"
/db_xref="EnsemblGenomes-Tr:CCP46041"
/db_xref="GOA:O05842"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O05842"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46041.1"
/translation="MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPK
LPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINL
GSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPT
AYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPE
VYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANP
PGYLPA"
gene 3600635..3600823
/locus_tag="Rv3224A"
CDS 3600635..3600823
/codon_start=1
/transl_table=11
/locus_tag="Rv3224A"
/product="Conserved hypothetical protein"
/note="Rv3224A, len: 62 aa. Conserved hypothetical protein
(possibly gene fragment), overlaps Rv3224. Similar to
N-terminus of ML0799|AL583919_131 conserved hypothetical
protein from Mycobacterium leprae (135 aa), FASTA scores:
opt: 104, E(): 0.78, (59.37% identity in 32 aa overlap).
Note that upstream ORF Rv3224B is similar to C-terminus of
ML0799. There appears to be no frameshift as sequence is
identical in strain CDC1551 and in Mycobacterium bovis.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3224A"
/db_xref="EnsemblGenomes-Tr:CCP46042"
/db_xref="UniProtKB/TrEMBL:Q6MWZ5"
/protein_id="CCP46042.1"
/translation="MRRSASTCGWKTPTRRGTSRPSDSKTLILELPDERAVAIVPVPS
KLSLKAAGGPRGAQSGHG"
gene 3600801..3601019
/locus_tag="Rv3224B"
CDS 3600801..3601019
/codon_start=1
/transl_table=11
/locus_tag="Rv3224B"
/product="Conserved hypothetical protein"
/note="Rv3224B, len: 72 aa. Conserved hypothetical protein
(possibly gene fragment), similar to C-terminal part of
ML0799|AL583919_131 conserved hypothetical protein from
Mycobacterium leprae (135 aa), FASTA scores: opt: 229,
E(): 2e-09, (60.00% identity in 70 aa overlap). Note that
downstream ORF Rv3224A is similar to N-terminus of ML0799.
There appears to be no frameshift as sequence is identical
in strain CDC1551 and in Mycobacterium bovis. Predicted to
be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3224B"
/db_xref="EnsemblGenomes-Tr:CCP46043"
/db_xref="GOA:Q6MWZ4"
/db_xref="InterPro:IPR007214"
/db_xref="InterPro:IPR036754"
/db_xref="UniProtKB/TrEMBL:Q6MWZ4"
/protein_id="CCP46043.1"
/translation="MPKAAMAKPAAAEQATGYVVGGISPFGQRKRLRTVVDVSALSWD
RVLRCRQTALGRHGGPAGPDHLDQRDHR"
gene complement(3601016..3602440)
/locus_tag="Rv3225c"
CDS complement(3601016..3602440)
/codon_start=1
/transl_table=11
/locus_tag="Rv3225c"
/product="GCN5-related N-acetyltransferase, phosphorylase"
/note="Rv3225c, (MTCY07D11.01), len: 474 aa. Conserved
hypothetical protein has GNAT (Gcn5-related
N-acetyltransferase) domain in N-terminal part (see
Vetting et al. 2005) and phosphotransferase domain in
C-terminal part. C-terminal part shows similarity to
various bacterial phosphotransferases e.g.
BAB49093|MLL1809 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (298 aa),FASTA scores: opt: 557, E():
2.8e-26, (34.55% identity in 295 aa overlap);
P14509|KKA8_ECOLI|APHA aminoglycoside
3'-phosphotransferase from Escherichia coli (271 aa),
FASTA scores: opt: 194, E(): 0.00018, (27.75% identity in
227 aa overlap); Q53826|CPH capreomycin phosphotransferase
from Streptomyces capreolus (281 aa), FASTA scores: opt:
178,E(): 0.0017, (30.5% identity in 269 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3225c"
/db_xref="EnsemblGenomes-Tr:CCP46044"
/db_xref="GOA:O05841"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR002575"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/TrEMBL:O05841"
/protein_id="CCP46044.1"
/translation="MRFAKLSDGLSDGIVTLSPLCLDDVDAHLAGGDERLVRWLSGMP
STRASVEAYIRHCREQWVTGGPLRSFGIRTVAETIVGTIDLRFDGEGLASGQVNVAYG
LYPSWRGRGLATRAVDLVCQYAAEHGATEAVIKVEPENSASARVALRAGFAFVRRICE
QDGTVFDRYERVLRAKMHADEVDIDEDLVRRLLRAQFPQWADLPIAPVRSAGTDNAMY
RLGEDLAVRIPRIGWAIESLRTEQQWLPRIAAHLGVASPVPVGLGSPAEGFGWPWSVC
RWVAGENPSAAEFVEPNRAVEDLADFITALRATDPMGGPPAKRGAPLGEQDAEVRAAL
AALDGIIDVHAATAAWESALRVPPYAGPPMWFHGDLSRFNILTAQGRLTGVIDFGLMG
VGDPSVDLIIAWNLLSAPARAQFRVAVGAADDDWMRGRGRALAIALIALPYYQDTNPP
LAASARYAIGEVLADFRYGARPGC"
gene complement(3602564..3603322)
/locus_tag="Rv3226c"
CDS complement(3602564..3603322)
/codon_start=1
/transl_table=11
/locus_tag="Rv3226c"
/product="Conserved hypothetical protein"
/note="Rv3226c, (MTCY20B11.01c), len: 252 aa. Conserved
hypothetical protein, similar to various hypothetical
bacterial proteins e.g. Q9CCI2|ML0793 putative
bacteriophage protein from Mycobacterium leprae (252
aa),FASTA scores: opt: 1183, E(): 3.8e-68, (70.65%
identity in 252 aa overlap); BAB54183|MLR7795 hypothetical
protein from Rhizobium loti (Mesorhizobium loti) (369 aa),
FASTA scores: opt: 417, E(): 2.9e-19, (33.75% identity in
252 aa overlap); O64131 YOQW protein from Bacteriophage
SPBc2 (224 aa), FASTA scores: opt: 413, E(): 3.4e-19,
(38.5% identity in 244 aa overlap); O31916 YOQW protein
from Bacillus subtilis (224 aa), FASTA scores: opt: 413,
E(): 3.4e-19,(38.5% identity in 244 aa overlap); O34906
YOAM protein from Bacillus subtilis (227 aa), FASTA
scores: opt: 401,E(): 2e-18, (37.7% identity in 244 aa
overlap); Q9K4A5|SC7E4.11 hypothetical 30.8 KDA protein
from Streptomyces coelicolor (271 aa), FASTA scores: opt:
383,E(): 3.3e-17, (39.6% identity in 283 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3226c"
/db_xref="EnsemblGenomes-Tr:CCP46045"
/db_xref="GOA:O05872"
/db_xref="InterPro:IPR003738"
/db_xref="InterPro:IPR036590"
/db_xref="UniProtKB/TrEMBL:O05872"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46045.1"
/translation="MCGRFAVTTDPAQLAEKITAIDEATGCGGGKTSYNVAPTDTIAT
VVSRHSEPDDEPTRRVRLMRWGLIPSWIKAGPGGAPDAKGPPLINARADKVATSPAFR
SAVRSKRCLVPMDGWYEWRVDPDATPGRPNAKTPFFLHRHDGALLFTAGLWSVWKSYR
SAPPLLSCTVITTDAVGELAEIHDRMPLLLAEEDWDDWLNPDAPPDPELLARPPDVRD
IALRQVSTLVNNVRNNGPELLEPARSQPEQIQLL"
gene 3603377..3604729
/gene="aroA"
/locus_tag="Rv3227"
CDS 3603377..3604729
/codon_start=1
/transl_table=11
/gene="aroA"
/locus_tag="Rv3227"
/product="3-phosphoshikimate 1-carboxyvinyltransferase
AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP
synthase) (EPSPS)"
/note="Rv3227, (MTCY20B11.02), len: 450 aa.
AroA,3-phosphoshikimate 1-carboxyvinyl transferase (see
citation below), equivalent (but C-terminus longer) to
Q9CCI3|AROA|ML0792 putative 3-phosphoshikimate
1-carboxyvinyl transferase from Mycobacterium leprae (430
aa), FASTA scores: opt: 1466, E(): 1.4e-78, (55.05%
identity in 427 aa overlap). Contains PS00885 EPSP
synthase signature 2. Belongs to the EPSP synthase
family."
/db_xref="EnsemblGenomes-Gn:Rv3227"
/db_xref="EnsemblGenomes-Tr:CCP46046"
/db_xref="GOA:P9WPY5"
/db_xref="InterPro:IPR001986"
/db_xref="InterPro:IPR006264"
/db_xref="InterPro:IPR013792"
/db_xref="InterPro:IPR023193"
/db_xref="InterPro:IPR036968"
/db_xref="PDB:2BJB"
/db_xref="PDB:2O0B"
/db_xref="PDB:2O0D"
/db_xref="PDB:2O0E"
/db_xref="PDB:2O0X"
/db_xref="PDB:2O0Z"
/db_xref="PDB:2O15"
/db_xref="UniProtKB/Swiss-Prot:P9WPY5"
/inference="protein motif:PROSITE:PS00885"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46046.1"
/translation="MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGRGAS
TISGALRSRDTELMLDALQTLGLRVDGVGSELTVSGRIEPGPGARVDCGLAGTVLRFV
PPLAALGSVPVTFDGDQQARGRPIAPLLDALRELGVAVDGTGLPFRVRGNGSLAGGTV
AIDASASSQFVSGLLLSAASFTDGLTVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDST
PNRWQVRPGPVAARRWDIEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAI
LRQLNAVVIHADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGI
AHLRGHETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHRMAMAGAI
IGLRVAGVEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPRSGQRARRATGQGSGG
"
gene 3604726..3605718
/locus_tag="Rv3228"
CDS 3604726..3605718
/codon_start=1
/transl_table=11
/locus_tag="Rv3228"
/product="Conserved hypothetical protein"
/note="Rv3228, (MTCY20B11.03), len: 330 aa. Conserved
hypothetical protein, equivalent to Q9CCI4|ML0791
hypothetical protein from Mycobacterium leprae (327
aa),FASTA scores: opt: 1828, E(): 1e-98, (84.0% identity
in 331 aa overlap). Also similar to several hypothetical
bacterial proteins e.g. Q9K4A8|SC7E4.08c from Streptomyces
coelicolor (337 aa), FASTA scores: opt: 1051, E(): 1e-53,
(52.65% identity in 338 aa overlap); Q9HUL3|PA4952 from
Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 392
,E(): 1.4e-15,(34.85% identity in 281 aa overlap);
Q9PFV1|XF0556 from Xylella fastidiosa (341 aa), FASTA
scores: opt: 367, E(): 4e-14, (36.85% identity in 247 aa
overlap); P45339|YJEQ_HAEIN|HI1714 from Haemophilus
influenzae (346 aa), FASTA scores: opt: 355, E(): 2e-13,
(31.65% identity in 281 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A."
/db_xref="EnsemblGenomes-Gn:Rv3228"
/db_xref="EnsemblGenomes-Tr:CCP46047"
/db_xref="GOA:O05873"
/db_xref="InterPro:IPR004881"
/db_xref="InterPro:IPR010914"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR030378"
/db_xref="UniProtKB/TrEMBL:O05873"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46047.1"
/translation="MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGR
WGCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVL
RRTADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKT
DLAPAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLV
PEADRAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVL
LAFSDLAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT"
gene complement(3605751..3607034)
/gene="desA3"
/locus_tag="Rv3229c"
CDS complement(3605751..3607034)
/codon_start=1
/transl_table=11
/gene="desA3"
/locus_tag="Rv3229c"
/product="Possible linoleoyl-CoA desaturase
(delta(6)-desaturase)"
/note="Rv3229c, (MTCY20B11.04c), len: 427 aa.
DesA3,linoleoyl-CoA desaturase, showing similarity with
desaturases and other proteins e.g. Q08871|DES6|SLL0262
linoleoyl-CoA desaturase from Synechocystis sp. strain PCC
6803 (359 aa), FASTA scores: opt: 319, E(): 4e-13, (25.1%
identity in 295 aa overlap); Q54795|DESD delta 6
desaturase from Spirulina platensis (368 aa), FASTA
scores: opt: 268,E(): 7.7e-10, (25.0% identity in 300 aa
overlap); Q9ZTU8|S276 protein with similarity to
cytochrome B5 domain from Triticum aestivum (Wheat) (469
aa), FASTA scores: opt: 240, E(): 5.9e-08, (27.05%
identity in 266 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3229c"
/db_xref="EnsemblGenomes-Tr:CCP46048"
/db_xref="GOA:P9WNZ3"
/db_xref="InterPro:IPR005804"
/db_xref="UniProtKB/Swiss-Prot:P9WNZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46048.1"
/translation="MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIR
RTIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWMND
PEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVTRDQRWKRYNI
FNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVA
FPALTSLSPGATYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKG
QWYLRQMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYD
LPYTTGSFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPV
TGRRRGLKTAIAAVRGRRRSKRMAKSVTEPDDLAA"
gene complement(3607112..3608254)
/locus_tag="Rv3230c"
CDS complement(3607112..3608254)
/codon_start=1
/transl_table=11
/locus_tag="Rv3230c"
/product="Hypothetical oxidoreductase"
/note="Rv3230c, (MTCY20B11.05c), len: 380 aa. Putative
oxidoreductase, with some similarity to various
proteins,especially reductases e.g. Q9HUS4|PA4889 probable
oxidoreductase from Pseudomonas aeruginosa (366 aa), FASTA
scores: opt: 516, E(): 1.8e-24, (33.8% identity in 367 aa
overlap); P95533|TDNB electron transfer protein from
Pseudomonas putida (337 aa), FASTA scores: opt: 380, E():
4e-16, (30.7% identity in 277 aa overlap);
BAB34381|ECS0958 NADH oxidoreductase for the HCP from
Escherichia coli strain O157:H7 (322 aa), FASTA scores:
opt: 369, E(): 1.8e-15, (28.65% identity in 328 aa
overlap); Q44253|ATDA5 aniline dioxygenase reductase
component from Acinetobacter sp. (336 aa), FASTA scores:
opt: 305, E(): 1.6e-11, (27.4% identity in 303 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3230c"
/db_xref="EnsemblGenomes-Tr:CCP46049"
/db_xref="GOA:P9WNE9"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR001433"
/db_xref="InterPro:IPR001709"
/db_xref="InterPro:IPR008333"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR036010"
/db_xref="InterPro:IPR039261"
/db_xref="UniProtKB/Swiss-Prot:P9WNE9"
/protein_id="CCP46049.1"
/translation="MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLL
PDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLV
DGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGN
FVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELA
ALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSA
GASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCR
MGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI"
gene complement(3608364..3608873)
/locus_tag="Rv3231c"
CDS complement(3608364..3608873)
/codon_start=1
/transl_table=11
/locus_tag="Rv3231c"
/product="Conserved protein"
/note="Rv3231c, (MTCY20B11.06c), len: 169 aa. Conserved
protein, similar to Q9KYX9|SCE33.03c hypothetical 17.4 KDA
protein from Streptomyces coelicolor (167 aa), FASTA
scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3231c"
/db_xref="EnsemblGenomes-Tr:CCP46050"
/db_xref="UniProtKB/TrEMBL:O05876"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46050.1"
/translation="MTQVYIPATLAMLQRLVADGALWPVNGTAFAVTPTLRESYAEGD
DEELAEVALREAALASLRLLAADIGATADALPPRRAVLAAEVDDATYRPDLDDAVVRL
AGPITIDQVVAAYVDNAGAEPAVMAAIAVIDAADLGDEDAELVVGDAQDHDLAWYANQ
ELPFLLDLL"
gene complement(3608870..3609757)
/gene="ppk2"
/locus_tag="Rv3232c"
CDS complement(3608870..3609757)
/codon_start=1
/transl_table=11
/gene="ppk2"
/locus_tag="Rv3232c"
/product="Polyphosphate kinase Ppk2 (polyphosphoric acid
kinase)"
/note="Rv3232c, (MTCY20B11.07c), len: 295 aa (start
uncertain). Ppk2, polyphosphate kinase 2, highly similar
to Q9I154|PA2428 hypothetical protein from Pseudomonas
aeruginosa (304 aa), FASTA scores: opt: 1057, E():
6.8e-62,(60.7% identity in 252 aa overlap); Q9I6Z1|PA0141
hypothetical protein from Pseudomonas aeruginosa (298
aa),FASTA scores: opt: 990, E(): 1.6e-57, (54.6% identity
in 249 aa overlap); and other hypothetical bacterial
proteins. Note that previously known as pvdS. Ppk2|Rv3232c
and NdkA|Rv2445c interact (See Sureka et al., 2009)."
/db_xref="EnsemblGenomes-Gn:Rv3232c"
/db_xref="EnsemblGenomes-Tr:CCP46051"
/db_xref="GOA:O05877"
/db_xref="InterPro:IPR016898"
/db_xref="InterPro:IPR022486"
/db_xref="InterPro:IPR022488"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:O05877"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46051.1"
/translation="MDIPSVDVSTATNDGASSRAKGHRSAAPGRRKISDAVYQAELFR
LQTEFVKLQEWARHSGARLVVIFEGRDGAGKGGAIKRITEYLNPRVARIAALPAPTDR
ERGQWYYQRYIAHLPAKGEIVLFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQM
LIDDGILLRKYWFSVSDAEQLRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEM
MVHTDTPVSPWYVVESDIKKHARLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGNYRR
PPRELSTYVDDYVATLIAR"
gene complement(3609781..3610371)
/locus_tag="Rv3233c"
CDS complement(3609781..3610371)
/codon_start=1
/transl_table=11
/locus_tag="Rv3233c"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv3233c, (MTCY20B11.08c), len: 196 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004),
similar to C-terminus of Q9RIU8|SCM11.13c hypothetical
47.1 KDA protein from Streptomyces coelicolor (446 aa),
FASTA scores: opt: 308, E(): 1.2e-12, (32.0% identity in
200 aa overlap); and several hypothetical M. tuberculosis
proteins e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497
aa),FASTA scores: opt: 248, E(): 9.8e-09, (27.5% identity
in 200 aa overlap); MTCY28_26; MTCY493_29; MTCY31_25;
MTCY31_25."
/db_xref="EnsemblGenomes-Gn:Rv3233c"
/db_xref="EnsemblGenomes-Tr:CCP46052"
/db_xref="GOA:O05878"
/db_xref="InterPro:IPR009721"
/db_xref="UniProtKB/TrEMBL:O05878"
/protein_id="CCP46052.1"
/translation="MIAGALGNWLMSRGEAVAPTATVRAMAPLSVYADDQLDSTGPGQ
AISQVTPFLVDLPVGEGNAVVRLSQIAHATESNPTAASLVDARTIVTLSGLAPATLHA
MGVRVATSFSARLFNLLITNAPGTQSQMYIAGTKLLETYSVPPLLHNQALAISVTSYN
GMLYFGINADRDAMSDVDLLPGLLSQALDELLEASR"
gene complement(3610374..3611189)
/gene="tgs3"
/locus_tag="Rv3234c"
CDS complement(3610374..3611189)
/codon_start=1
/transl_table=11
/gene="tgs3"
/locus_tag="Rv3234c"
/product="Putative triacylglycerol synthase
(diacylglycerol acyltransferase) Tgs3"
/note="Rv3234c, (MTCY20B11.09c), len: 271 aa. Putative
tgs3, triacylglycerol synthase (See Daniel et al.,
2004),similar to C-terminus of Mycobacterium tuberculosis
hypothetical proteins e.g.
P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA
scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa
overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26;
MTV013_8; MTY13E12_33; etc. Also similar to
Q9X7A8|MLCB1610.05|ML1244 conserved membrane protein from
Mycobacterium leprae (491 aa), FASTA scores: opt: 309,
E(): 4.3e-12, (33.35% identity in 189 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3234c"
/db_xref="EnsemblGenomes-Tr:CCP46053"
/db_xref="GOA:P9WKC5"
/db_xref="InterPro:IPR004255"
/db_xref="UniProtKB/Swiss-Prot:P9WKC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46053.1"
/translation="MVTRLSASDASFYQLENTATPMYVGLLLILRRPRAGLSYEALLE
TVEQRLPQIPRYRQKVQEVKLGLARPVWIDDRDFDITYHVRRSALPSPGSDEQLHELI
ARLAARPLDKSRPLWEMYLVEGLEKNRIALYTKSHQALINGVTALAIGHVIADRTRRP
PAFPEDIWVPERDPGTTRLLLRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRK
VLDIARTVARGTAPSSPLNATVSRNRRFTVARASLDDYRTVRARYDCDSTTWC"
gene 3611300..3611941
/locus_tag="Rv3235"
CDS 3611300..3611941
/codon_start=1
/transl_table=11
/locus_tag="Rv3235"
/product="Hypothetical alanine arginine proline rich
protein"
/note="Rv3235, (MTCY20B11.10), len: 213 aa. Hypothetical
unknown ala-, arg-, pro-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv3235"
/db_xref="EnsemblGenomes-Tr:CCP46054"
/db_xref="GOA:O05880"
/db_xref="UniProtKB/TrEMBL:O05880"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46054.1"
/translation="MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTF
AVTPVVEYEPPPRNIPPCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRL
RQAGTFADAALRRVLEVIDRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRR
IRLTPAGPDTADTAAEVFGTYSRGDRIHAIACRVEQRPAGNETRWLMVALHIG"
gene complement(3611959..3613116)
/gene_synonym="kefB"
/locus_tag="Rv3236c"
CDS complement(3611959..3613116)
/codon_start=1
/transl_table=11
/gene_synonym="kefB"
/locus_tag="Rv3236c"
/product="Probable conserved integral membrane transport
protein"
/note="Rv3236c, (MTCY20B11.11c), len: 385 aa. Probable
conserved integral membrane transport protein, possibly
cation (Na/H) transporter, equivalent to Q9CCI5|ML0782
putative transmembrane transport protein from
Mycobacterium leprae (385 aa), FASTA scores: opt: 1975,
E(): 2.4e-108,(81.55% identity in 385 aa overlap). Highly
similar to others e.g. O69958|SC4H2.03c putative
transmembrane transport protein from Streptomyces
coelicolor (411 aa),FASTA scores: opt: 1226, E(): 1.6e-64,
(53.5% identity in 372 aa overlap); Q9XAKO|SC66T3.13c
putative transmembrane transport protein from Streptomyces
coelicolor (403 aa),FASTA scores: opt: 1198, E(): 6.8e-63,
(53.25% identity in 370 aa overlap); Q9RV80|DR1149
putative Na+/H+ antiporter from Deinococcus radiodurans
(383 aa), FASTA scores: opt: 1069, E(): 2.3e-55, (47.35%
identity in 376 aa overlap); Q9L191|SC10G8.11 putative
transmembrane transport protein from Streptomyces
coelicolor (446 aa), FASTA scores: opt: 695, E(): 1.9e-33,
(38.05% identity in 384 aa overlap); Q9RRW8|DR2367
putative glutathione-regulated potassium-efflux system
protein KEFB from Deinococcus radiodurans (575 aa), FASTA
scores: opt: 414, E(): 6.2e-17,(30.25% identity in 380 aa
overlap); etc. Seems to belong to the CPA2 family. Note
that previously known as kefB."
/db_xref="EnsemblGenomes-Gn:Rv3236c"
/db_xref="EnsemblGenomes-Tr:CCP46055"
/db_xref="GOA:L7N665"
/db_xref="InterPro:IPR006153"
/db_xref="InterPro:IPR038770"
/db_xref="UniProtKB/TrEMBL:L7N665"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46055.1"
/translation="MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLG
NGGILGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLRHHLPSAGVDIVLNAT
PGAVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDF
AMAAYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPDSEQL
LLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRARMVLTPLRDLFATIFFL
GIGLSVDPGKLVSMLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARG
EFSLIIIGLAGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN"
gene complement(3613121..3613603)
/locus_tag="Rv3237c"
CDS complement(3613121..3613603)
/codon_start=1
/transl_table=11
/locus_tag="Rv3237c"
/product="Conserved protein"
/note="Rv3237c, (MTCY20B11.12c), len: 160 aa. Conserved
protein, equivalent to Q9CCI6|ML0781 hypothetical protein
from Mycobacterium leprae (160 aa), FASTA scores: opt:
828,E(): 1.5e-45, (80.6% identity in 160 aa overlap); and
similar to other hypothetical bacterial proteins and more
weakly to putative potassium channels e.g. Q9RV81|DR1148
conserved hypothetical protein from Deinococcus
radiodurans (175 aa), FASTA scores: opt: 420, E():
9.5e-20, (37.95% identity in 158 aa overlap);
O69959|SC4H2.04c hypothetical 17.1 KDA protein from
Streptomyces coelicolor (161 aa),FASTA scores: opt: 315,
E(): 3.8e-13, (40.0% identity in 150 aa overlap);
Q9HNH3|PCHB|VNG2104G potassium channel homolog from
Halobacterium sp. strain NRC-1 (418 aa), FASTA scores:
opt: 158, E(): 0.007, (31.45% identity in 124 aa overlap);
Q58752|YD57_METJA|MJ1357 putative potassium channel
protein from Methanococcus jannaschii (343 aa),FASTA
scores: opt: 143, E(): 0.053, (33.8% identity in 68 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3237c"
/db_xref="EnsemblGenomes-Tr:CCP46056"
/db_xref="GOA:O05882"
/db_xref="InterPro:IPR006037"
/db_xref="InterPro:IPR026278"
/db_xref="InterPro:IPR036721"
/db_xref="UniProtKB/TrEMBL:O05882"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46056.1"
/translation="MDVKEVLLPGVGLRYEFTSYRGDRIGIVARRSGGFDVVLYGRDD
PDEARPVLRLTDEEAEAVAQILGAPRIAERFTELTREVPGLKAGQIHIRAGSLFVDRP
LGDTRARTRTGASIVAIVRDEDVLASPGPTDVLRAGDVLIVIGTEDGIAGVEQIVEKG
"
gene complement(3613664..3614398)
/locus_tag="Rv3238c"
CDS complement(3613664..3614398)
/codon_start=1
/transl_table=11
/locus_tag="Rv3238c"
/product="Probable conserved integral membrane protein"
/note="Rv3238c, (MTCY20B11.13c), len: 244 aa. Probable
conserved integral membrane protein, similar to several
hypothetical proteins and transmembrane proteins e.g.
Q9UN92|NRM29 multispanning nuclear envelope membrane
protein NURIM (fragment) from Homo sapiens (Human) (261
aa), FASTA scores: opt: 281, E(): 3.3e-11, (30.7% identity
in 189 aa overlap); Q9VEG9|CG7655 hypothetical protein
from Drosophila melanogaster (Fruit fly) (253 aa), FASTA
scores: opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa
overlap); BAB48937|MLR1600 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (222 aa), FASTA
scores: opt: 137, E(): 0.066, (28.1% identity in 185 aa
overlap); BAB57936|SAV1774 aesenical pump membrane protein
homolog from Staphylococcus aureus subsp. aureus Mu50 (430
aa), FASTA scores: opt: 125,E(): 0.68, (25.7% identity in
144 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3238c"
/db_xref="EnsemblGenomes-Tr:CCP46057"
/db_xref="GOA:O05883"
/db_xref="InterPro:IPR009915"
/db_xref="InterPro:IPR033580"
/db_xref="UniProtKB/Swiss-Prot:O05883"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46057.1"
/translation="MKRYLTIIYGAASYLVFLVAFGYAIGFVGDVVVPRTVDHAIAAP
IGQAVVVNLVLLGVFAVQHSVMARQGFKRWWTRFVPPSIERSTYVLLASVALLLLYWQ
WRTMPAVIWDVRQPAGRVALWALFWLGWATVLTSTFMINHFELFGLRQVYLAWRGKPY
TEIGFQAHLLYRWVRHPIMLGFVVAFWATPMMTAGHLLFAIGATGYILVALQFEERDL
LAALGDQYRDYRREVSMLLPWPHRHT"
gene complement(3614457..3617603)
/locus_tag="Rv3239c"
CDS complement(3614457..3617603)
/codon_start=1
/transl_table=11
/locus_tag="Rv3239c"
/product="Probable conserved transmembrane transport
protein"
/note="Rv3239c, (MTCY20B11.14c), len: 1048 aa. Probable
conserved transmembrane protein, organised in two domains.
Domain comprising first ~500 aa residues is similar to
various antibiotic resistance and efflux proteins and
contains sugar transport proteins signature 1 (PS00216);
e.g. Q9RL22|SC5G9.04c putative transmembrane efflux
protein from Streptomyces coelicolor (489 aa), FASTA
scores: opt: 905, E(): 3.1e-41, (36.95% identity in 482 aa
overlap); and O68912|FRNF putative antibiotic antiporter
from Streptomyces roseofulvus (517 aa), FASTA scores: opt:
866,E(): 4.1e-39, (37.1% identity in 512 aa overlap).
Second part, corresponding to last 550 aa residues, is
very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical
62.1 kDa protein from Mycobacterium tuberculosis (583 aa),
FASTA scores: E(): 2.1e-28, (36.5% identity in 572 aa
overlap). Also equivalent to Rv3728|MTV025.076 putative
two-domain membrane protein (similar to sugar transporter
family) from Mycobacterium tuberculosis (1065 aa), FASTA
scores: opt: 4328, E(): 0, (64.15% identity in 1046 aa
overlap); and similar to other Mycobacterium tuberculosis
proteins: MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E():
6.3e-32; MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E():
2.5e-26. Equivalent to AAK47679 Drug transporter from
Mycobacterium tuberculosis strain CDC1551 (1065 aa) but
shorter 20 aa. Contains cyclic nucleotide-binding domain
signature 2 (PS00889). Probably member of major
facilitator superfamily (MFS)."
/db_xref="EnsemblGenomes-Gn:Rv3239c"
/db_xref="EnsemblGenomes-Tr:CCP46058"
/db_xref="GOA:O05884"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR001423"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR004638"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR018488"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O05884"
/inference="protein motif:PROSITE:PS00889"
/inference="protein motif:PROSITE:PS00216"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46058.1"
/translation="MHISLHGGKGFANLTRRRRPSSASVLLVAGFGAFLAFLDSTIVN
IAFPDIQRSFPSYDIGSLSWILNGYNIVFAAFMVAAGRLADLLGRRRTFLSGVLVFTI
ASGLCAVAGSVEQLVAFRVLQGIGAAILVPASLALVVEGFDAARRAHAIGLWGAAAAI
AAGLGPPIGGLLVEWAGWRWVLLVNVPLGIVAAIATKRMLVESRASGRRRMPDLRGAL
LLAVTLGLVTLGLVKGPDWGWLSVATVGSFLASVLTSVGFVHSSRSHPAPLVEPALLR
SRSFVAGNLLTLVAAAGFYCYGLTHVLYLNYVWHYSLLKAGFAIAPAAVVAAVVAAAL
GRVAGRHGHRVIVLVGALVWAGSLVWYLQRVGSEPDFLRVWLPGQLLQGIGVGATLPV
LSSAALAEVAKGGSYATSSAVVSTTRQLGAVLGVAVMVILIGKPEHGTAEEALRRGWA
MAAICFIAVAVAAAVLGRTNRNPVQMPAPEPAIAPRLEPPIPQPAAAPIEHWAAGDAD
PLGNLPLFAGLDAATLAQLGEHVEDVELEAGCYLFHEGDPSDSLYVIRTGRVQVLQDS
IVLKELGRGEVLGELGLLIDAPRSATVRALRDTKLVRLTKAQFDEIADHGALAALVKV
LATRLREAPPPATDSTSPEVVVSVIGVSGDAPVPAVAAGLLTALSARLRAVDPGRVDR
DGLDRAERVADKVVLHAAVEDAGWRDFCLRVADRIVLVAGDPNPQAARLPARARGADL
VLAGPAASREHRRQWEELITPRSVHVVHYRRILENVRPLAARIAGRSIGLVLGGGGAR
GFAHLGVLDELERVGVTIDRFAGTSMGAVIAVFGACGMDAATADAYAYEYFIRHNPLS
DYAFPVRGLVRGRRTLTLLEAAFGDRLVEELPKEFRCVSVDLLARRPVVHRRGRLVDV
IGCSLRLPGIYPPQVYNGRLHVDGGVLDNLPVSTRASPDGPLIAVSIGLGGGGPGSAR
QDGSPKVPGIGDTLMRTMTIGSQRGADAALSLAQVVIRPDTGAVGLLEFHQIDAAREA
GRVAAREAMPHIMALLNR"
gene complement(3617682..3620531)
/gene="secA1"
/gene_synonym="secA"
/locus_tag="Rv3240c"
CDS complement(3617682..3620531)
/codon_start=1
/transl_table=11
/gene="secA1"
/gene_synonym="secA"
/locus_tag="Rv3240c"
/product="Probable preprotein translocase SecA1 1 subunit"
/note="Rv3240c, (MTCY20B11.15c), len: 949 aa. Probable
secA1, preprotein translocase subunit, component of
secretion apparatus (see citations below), highly similar
to many e.g. P57996|SEA1_MYCLE from Mycobacterium leprae
(940 aa), FASTA scores: opt: 5044, E(): 0, (87.5% identity
in 849 aa overlap); P95759|SECA_STRGR from Streptomyces
griseus (940 aa), FASTA scores: opt: 2612, E():
1.9e-134,(61.35% identity in 960 aa overlap);
P28366|SECA_BACSU|div+ from Bacillus subtilis (841 aa),
FASTA scores: opt: 1776,E(): 4.9e-89, (48.05% identity in
837 aa overlap); etc. Belongs to the SecA family. Part of
the prokaryotic protein translocation apparatus which
comprise SECA, SECD|Rv2587c,SECE|Rv0638, SECF|Rv2586c,
SECG|Rv1440 and SECY|Rv0732. Note that previously known as
secA. Binds ATP."
/db_xref="EnsemblGenomes-Gn:Rv3240c"
/db_xref="EnsemblGenomes-Tr:CCP46059"
/db_xref="GOA:P9WGP5"
/db_xref="InterPro:IPR000185"
/db_xref="InterPro:IPR011115"
/db_xref="InterPro:IPR011116"
/db_xref="InterPro:IPR011130"
/db_xref="InterPro:IPR014018"
/db_xref="InterPro:IPR020937"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036266"
/db_xref="InterPro:IPR036670"
/db_xref="PDB:1NKT"
/db_xref="PDB:1NL3"
/db_xref="UniProtKB/Swiss-Prot:P9WGP5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46059.1"
/translation="MLSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTD
EFKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLGNVAEMK
TGEGKTLTCVLPAYLNALAGNGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILATM
TPDERRVAYNADITYGTNNEFGFDYLRDNMAHSLDDLVQRGHHYAIVDEVDSILIDEA
RTPLIISGPADGASNWYTEFARLAPLMEKDVHYEVDLRKRTVGVHEKGVEFVEDQLGI
DNLYEAANSPLVSYLNNALKAKELFSRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGM
HQAIEAKEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVS
IPTNMPMIREDQSDLIYKTEEAKYIAVVDDVAERYAKGQPVLIGTTSVERSEYLSRQF
TKRRIPHNVLNAKYHEQEATIIAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRL
RERGLDPVETPEEYEAAWHSELPIVKEEASKEAKEVIEAGGLYVLGTERHESRRIDNQ
LRGRSGRQGDPGESRFYLSLGDELMRRFNGAALETLLTRLNLPDDVPIEAKMVTRAIK
SAQTQVEQQNFEVRKNVLKYDEVMNQQRKVIYAERRRILEGENLKDQALDMVRDVITA
YVDGATGEGYAEDWDLDALWTALKTLYPVGITADSLTRKDHEFERDDLTREELLEALL
KDAERAYAAREAELEEIAGEGAMRQLERNVLLNVIDRKWREHLYEMDYLKEGIGLRAM
AQRDPLVEYQREGYDMFMAMLDGMKEESVGFLFNVTVEAVPAPPVAPAAEPAELAEFA
AAAAAAAQQRSAVDGGARERAPSALRAKGVASESPALTYSGPAEDGSAQVQRNGGGAH
KTPAGVPAGASRRERREAARRQGRGAKPPKSVKKR"
gene complement(3620610..3621254)
/locus_tag="Rv3241c"
CDS complement(3620610..3621254)
/codon_start=1
/transl_table=11
/locus_tag="Rv3241c"
/product="Conserved protein"
/note="Rv3241c, (MTCY20B11.16c), len: 214 aa. Conserved
protein, similar to many hypothetical proteins and to some
putative ribosomal proteins e.g. Q9CCI7|ML0778
hypothetical protein from Mycobacterium leprae (229 aa),
FASTA scores: opt: 1234, E(): 1.3e-72, (89.3% identity in
206 aa overlap); Q9KYX2|SCE33.11c hypothetical 27.9 KDA
protein from Streptomyces coelicolor (254 aa), FASTA
scores: opt: 487, E(): 2.2e-24, (47.6% identity in 210 aa
overlap); Q9FLV3 protein similar to ribosomal protein 30S
subunit from Arabidopsis thaliana (Mouse-ear cress) (365
aa), FASTA scores: opt: 264, E(): 7e-10, (26.4% identity
in 212 aa overlap); P19954|RR30_SPIOL|RPS22
plastid-specific 30S ribosomal protein 1, chloroplast,
from Spinacia oleracea (Spinach) (302 aa), FASTA scores:
opt: 261, E(): 9.3e-10,(26.15% identity in 214 aa
overlap); P47995|YSEA_STACA hypothetical protein in SECA
5'region (ORF1) (fragment) (belongs to the S30AE family of
ribosomal proteins) from Staphylococcus carnosus (165 aa),
FASTA scores: opt: 201,E(): 4.2e-06, (33.35% identity in
147 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3241c"
/db_xref="EnsemblGenomes-Tr:CCP46060"
/db_xref="GOA:O05886"
/db_xref="InterPro:IPR003489"
/db_xref="InterPro:IPR032528"
/db_xref="InterPro:IPR034694"
/db_xref="InterPro:IPR036567"
/db_xref="InterPro:IPR038416"
/db_xref="UniProtKB/Swiss-Prot:O05886"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46060.1"
/translation="MDSGQVLAEPKSNAEIVFKGRNVEIPDHFRIYVSQKLARLERFD
RTIYLFDVELDHERNRRQRKSCQRVEITARGRGPVVRGEACADSFYAALESAVVKLES
RLRRGKDRRKVHYGDKTPVSLAEATAVVPAPENGFNTRPAEAHDHDGAVVEREPGRIV
RTKEHPAKPMSVDDALYQMELVGHDFFLFYDKDTERPSVVYRRHAYDYGLIRLA"
gene complement(3621570..3622211)
/locus_tag="Rv3242c"
CDS complement(3621570..3622211)
/codon_start=1
/transl_table=11
/locus_tag="Rv3242c"
/product="Conserved hypothetical protein"
/note="Rv3242c, (MTCY20B11.17c), len: 213 aa. Conserved
hypothetical protein, highly similar in N-terminus to
Q9CCI9|ML0776 hypothetical protein from Mycobacterium
leprae (85 aa), FASTA scores: opt: 324, E():
1.7e-13,(78.1% identity in 64 aa overlap). Also similar to
Q9RUJ7|DR1389 putative competence protein COMF from
Deinococcus radiodurans (219 aa), FASTA scores: opt:
223,E(): 6.3e-07, (35.8% identity in 215 aa overlap);
BAB50338|MLL3453 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (240 aa), FASTA scores: opt: 218,
E(): 1.4e-06, (28.5% identity in 224 aa overlap);
Q9A9Y1|CC0830 competence protein F from Caulobacter
crescentus (265 aa),FASTA scores: opt: 182, E(): 0.00026,
(30.15% identity in 219 aa overlap); etc. Equivalent to
AAK47682 from Mycobacterium tuberculosis strain CDC1551
(241 aa) but shorter 29 aa. Contains purine/pyrimidine
phosphoribosyl transferases signature (PS00103). Seems to
belong to purine/pyrimidine phosphoribosyl transferase
family."
/db_xref="EnsemblGenomes-Gn:Rv3242c"
/db_xref="EnsemblGenomes-Tr:CCP46061"
/db_xref="GOA:O05887"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR029057"
/db_xref="UniProtKB/TrEMBL:O05887"
/inference="protein motif:PROSITE:PS00103"
/protein_id="CCP46061.1"
/translation="MLDLVLPLECGGCGAPATRWCAACAAELSVAAGEPHVVSPRVDP
QVPVFALGRYAGVRRQAILAMKEHGRRDLVAPLACALIVGVDHLLSWGMLENPLTMVP
APTRRWAARRRGGDPVSRMARIAGATLGRHHDVTVVPALRMRALARDSVGLGASARER
NITGRVLLRGQRPRNEVVLVDDIITTGATARESVRVLQAAGVRVGAVLAVAAA"
gene complement(3622249..3623091)
/locus_tag="Rv3243c"
CDS complement(3622249..3623091)
/codon_start=1
/transl_table=11
/locus_tag="Rv3243c"
/product="Unknown protein"
/note="Rv3243c, (MTCY20B11.18c), len: 280 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv3243c"
/db_xref="EnsemblGenomes-Tr:CCP46062"
/db_xref="GOA:O05888"
/db_xref="UniProtKB/TrEMBL:O05888"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46062.1"
/translation="MSPRVPRLRWDDPFRALDMLASLWSSTGMSLVSAGAAQAVAAPY
RTLFTTLQQLLIGKEVTVRIGDHDVVLTVTELDSALEPQGLAVGQLGEVRVAARGISW
DQHHLHSAVAVLRNVHIRPGVPPLVIAAPVELSSALPTEIFDDVLRQATPQLRGELSE
SGAARLRWARRPDWGGLEVDVDVAGTTSQTTLWLRPRTVITGQRRWTLPARTPAYRVP
LPELPHGLRITDVSLAADCLQLSALLPEWRTELPLRYLESVITQLSQGALSFVWPPLR
SGAD"
gene complement(3623159..3624910)
/gene="lpqB"
/locus_tag="Rv3244c"
CDS complement(3623159..3624910)
/codon_start=1
/transl_table=11
/gene="lpqB"
/locus_tag="Rv3244c"
/product="Probable conserved lipoprotein LpqB"
/note="Rv3244c, (MTCY20B11.19c), len: 583 aa. Probable
lpqB, conserved lipoprotein; contains appropriately placed
lipoprotein signature (PS00013). Equivalent to
Q9CCJ0|LPQB|ML0775 putative lipoprotein from Mycobacterium
leprae (589 aa), FASTA scores: opt: 3375, E():
1.4e-186,(87.9% identity in 579 aa overlap). Also similar
to various proteins (in particular transferases) e.g.
Q9KYX0|SCE33.13c putative lipoprotein from Streptomyces
coelicolor (615 aa),FASTA scores: opt: 228, E(): 1.3e-05,
(25.5% identity in 624 aa overlap); O87992|BBLPS1.19c
putative glutamine amidotransferase from Bordetella
bronchiseptica (Alcaligenes bronchisepticus) (628 aa),
FASTA scores: opt: 162, E(): 0.079, (28.05% identity in
171 aa overlap); Q9L2F4|SC7A8.01 putative sugar kinase
(fragment) from Streptomyces coelicolor (434 aa), FASTA
scores: opt: 143,E(): 0.72, (27.65% identity in 293 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3244c"
/db_xref="EnsemblGenomes-Tr:CCP46063"
/db_xref="GOA:P9WK37"
/db_xref="InterPro:IPR018910"
/db_xref="InterPro:IPR019606"
/db_xref="InterPro:IPR023959"
/db_xref="UniProtKB/Swiss-Prot:P9WK37"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46063.1"
/translation="MRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSP
GMDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAE
KVSVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSDGWRIDRLPNGVFLDWQQF
QETYKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLL
APPLRLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADI
RGPYVINADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVT
PVPGAFGRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHS
LSRPSWSLDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSR
DGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRT
DAAHPVSYVNLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGW
ADVPGLMVPGAAPVLPG"
gene complement(3624910..3626613)
/gene="mtrB"
/locus_tag="Rv3245c"
CDS complement(3624910..3626613)
/codon_start=1
/transl_table=11
/gene="mtrB"
/locus_tag="Rv3245c"
/product="Two component sensory transduction histidine
kinase MtrB"
/note="Rv3245c, (MTCY20B11.20c), len: 567 aa.
MtrB,sensor-like histidine kinase (see citations
below),equivalent to Q9CCJ1|MTRB or ML0774 putative
two-component system sensor kinase from Mycobacterium
leprae (562 aa),FASTA scores: opt: 3208, E(): 7.4e-173,
(88.7% identity in 566 aa overlap). Also similar to others
e.g. Q9KYW9|SCE33.14c putative two-component system
histidine kinase from Streptomyces coelicolor (688 aa),
FASTA scores: opt: 1355, E(): 1.1e-68, (48.95% identity in
515 aa overlap); etc. Relatives in Mycobacterium
tuberculosis are: MTCY369.03, E(): 1.5e-22; MTCY20G9.16,
E(): 1.9e-17. Similar to other prokaryotic sensory
transduction histidine kinases."
/db_xref="EnsemblGenomes-Gn:Rv3245c"
/db_xref="EnsemblGenomes-Tr:CCP46064"
/db_xref="GOA:P9WGK9"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:P9WGK9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46064.1"
/translation="MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVA
LTLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDS
SLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKA
GQAAYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATG
GLVLLVLLAGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFN
DMAESLSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSADLDPTLRR
STELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAG
IELLVDLPAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRD
YGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWGEPGEG
ACFRLTLPMVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPREHAEWS
G"
repeat_region complement(3626614..3626666)
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene complement(3626663..3627349)
/gene="mtrA"
/locus_tag="Rv3246c"
CDS complement(3626663..3627349)
/codon_start=1
/transl_table=11
/gene="mtrA"
/locus_tag="Rv3246c"
/product="Two component sensory transduction
transcriptional regulatory protein MtrA"
/note="Rv3246c, (MTCY20B11.21c), len: 228 aa.
MtrA,transcriptional activator, response regulator (see
citations below), equivalent to Q9CCJ2|MTRA|ML0773
putative two-component response regulator from
Mycobacterium leprae (228 aa), FASTA scores: opt: 1458,
E(): 1.4e-85, (98.7% identity in 228 aa overlap). Also
highly similar to others e.g. Q9F9J5|SCRA putative
response regulator from Streptomyces coelicolor (228 aa),
FASTA scores: opt: 1141,E(): 1.9e-65, (74.9% identity in
227 aa overlap); Q9KYW8|SCE33.15c putative two-component
system response regulator from Streptomyces coelicolor
(229 aa), FASTA scores: opt: 1141, E(): 1.9e-65, (74.9%
identity in 227 aa overlap); Q9F868|REGX3 response
regulator REGX3 from Mycobacterium smegmatis (228 aa),
FASTA scores: opt: 730,E(): 2.3e-39, (50.90% identity in
222 aa overlap); etc. Relatives in Mycobacterium
tuberculosis are: U01971|MTU01971_1; Q11156|RGX3_MYCTU;
MTCY20G9.17, E(): 0; MTCY31.31c, E(): 3.4e-29; MTCY369.02,
E(): 5.7e-28. Similar to bacterial regulatory proteins
involved in signal transduction. The N-terminal region is
similar to that of other regulatory components of sensory
transduction systems. Experiments showed mtrA is
differentially expressed in virulent and avirulent strains
during growth in macrophages."
/db_xref="EnsemblGenomes-Gn:Rv3246c"
/db_xref="EnsemblGenomes-Tr:CCP46065"
/db_xref="GOA:P9WGM7"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="PDB:2GWR"
/db_xref="PDB:3NHZ"
/db_xref="UniProtKB/Swiss-Prot:P9WGM7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46065.1"
/translation="MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTA
VRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDY
IMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFD
LLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTV
RGVGYKAGPP"
gene complement(3627419..3628063)
/gene="tmk"
/locus_tag="Rv3247c"
CDS complement(3627419..3628063)
/codon_start=1
/transl_table=11
/gene="tmk"
/locus_tag="Rv3247c"
/product="Thymidylate kinase Tmk (dTMP kinase) (thymidylic
acid kinase) (TMPK)"
/note="Rv3247c, (MTCY20B11.22c), len: 214 aa.
tmk,thymidylate kinase, equivalent to Q9CCJ3|TMK|ML0772
putative thymidylate kinase from Mycobacterium leprae (210
aa), FASTA scores: opt: 1023, E(): 4.8e-57, (77.3%
identity in 207 aa overlap). Also similar to other
thymidylate kinases e.g. Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from
Caulobacter crescentus (208 aa), FASTA scores: opt: 179,
E(): 0.0003,(31.3% identity in 214 aa overlap);
Q9V1E9|KTHY_PYRAB|TMK|PAB0319 from Pyrococcus abyssi (205
aa), FASTA scores: opt: 176, E(): 0.00045, (29.1% identity
in 189 aa overlap); etc. Belongs to the thymidylate kinase
family."
/db_xref="EnsemblGenomes-Gn:Rv3247c"
/db_xref="EnsemblGenomes-Tr:CCP46066"
/db_xref="GOA:P9WKE1"
/db_xref="InterPro:IPR018094"
/db_xref="InterPro:IPR018095"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR039430"
/db_xref="PDB:1G3U"
/db_xref="PDB:1GSI"
/db_xref="PDB:1GTV"
/db_xref="PDB:1MRN"
/db_xref="PDB:1MRS"
/db_xref="PDB:1N5I"
/db_xref="PDB:1N5J"
/db_xref="PDB:1N5K"
/db_xref="PDB:1N5L"
/db_xref="PDB:1W2G"
/db_xref="PDB:1W2H"
/db_xref="PDB:4UNN"
/db_xref="PDB:4UNP"
/db_xref="PDB:4UNQ"
/db_xref="PDB:4UNR"
/db_xref="PDB:4UNS"
/db_xref="PDB:5NQ5"
/db_xref="PDB:5NR7"
/db_xref="PDB:5NRN"
/db_xref="PDB:5NRQ"
/db_xref="UniProtKB/Swiss-Prot:P9WKE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46066.1"
/translation="MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVA
ADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAA
YSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGR
ARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS"
gene complement(3628160..3629647)
/gene="sahH"
/locus_tag="Rv3248c"
CDS complement(3628160..3629647)
/codon_start=1
/transl_table=11
/gene="sahH"
/locus_tag="Rv3248c"
/product="Probable adenosylhomocysteinase SahH
(S-adenosyl-L-homocysteine hydrolase) (adohcyase)"
/note="Rv3248c, (MTCY20B11.23c), len: 495 aa. Probable
sahH, adenosylhomocysteinase, equivalent to
Q9CCJ4|SAHH|ML0771 putative S-adenosyl-L-homocysteine
hydrolase from Mycobacterium leprae (492 aa), FASTA
scores: opt: 3019, E(): 1.3e-177, (91.4% identity in 489
aa overlap). Also highly similar to other
adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces
coelicolor (485 aa), FASTA scores: opt: 2258, E():
5.7e-131, (70.0% identity in 483 aa overlap);
P51540|SAHH_TRIVA from Trichomonas vaginalis (486
aa),FASTA scores: opt: 2005, E(): 1.8e-115, (62.05%
identity in 477 aa overlap); P35007|SAHH_CATRO from
Catharanthus roseus (Rosy periwinkle) (Madagascar
periwinkle) (485 aa), FASTA scores: opt: 1941, E():
1.5e-111, (60.15% identity in 492 aa overlap); etc. Has
S-adenosyl-L-homocysteine hydrolase signature (PS00739).
Belongs to the adenosylhomocysteinase family."
/db_xref="EnsemblGenomes-Gn:Rv3248c"
/db_xref="EnsemblGenomes-Tr:CCP46067"
/db_xref="GOA:P9WGV3"
/db_xref="InterPro:IPR000043"
/db_xref="InterPro:IPR015878"
/db_xref="InterPro:IPR020082"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR042172"
/db_xref="PDB:2ZIZ"
/db_xref="PDB:2ZJ0"
/db_xref="PDB:2ZJ1"
/db_xref="PDB:3CE6"
/db_xref="PDB:3DHY"
/db_xref="UniProtKB/Swiss-Prot:P9WGV3"
/inference="protein motif:PROSITE:PS00739"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46067.1"
/translation="MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMP
GLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHA
AAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDA
TMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEE
TTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGK
KVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIV
VTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTF
GDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLP
KHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY"
gene complement(3629752..3630387)
/locus_tag="Rv3249c"
CDS complement(3629752..3630387)
/codon_start=1
/transl_table=11
/locus_tag="Rv3249c"
/product="Possible transcriptional regulatory protein
(probably TetR-family)"
/note="Rv3249c, (MTCY20B11.24c), len: 211 aa. Possible
transcriptional regulatory protein, TetR family, with
similarity to several e.g. Q9AE61|ALKB1 putative
TetR-regulatory from Rhodococcus erythropolis (208
aa),FASTA scores: opt: 503, E(): 7.7e-26, (40.6% identity
in 192 aa overlap); CAC37620 putative TetR-regulatory
protein from Prauserella rugosa (212 aa), FASTA scores:
opt: 246,E(): 4.4e-09, (27.95% identity in 186 aa
overlap); Q9K4B0|SC7E4.06 putative TetR-family
transcriptional from Streptomyces coelicolor (203 aa),
FASTA scores: opt: 224,E(): 1.1e-07, (34.5% identity in
197 aa overlap); Q11063|YC55_MYCTU|Rv1255c|MT1294|MTCY50.2
7 hypothetical transcriptional regulator from
Mycobacterium tuberculosis (202 aa), FASTA scores: opt:
191, E(): 1.6e-05, (28.35% identity in 180 aa overlap);
etc. Equivalent to AAK47689 from Mycobacterium
tuberculosis strain CDC1551 (230 aa) but shorter 19 aa.
Could belong to the TetR/AcrR family of transcriptional
regulators. Possible helix-turn helix motif at aa 44-65
(+6.66 SD)."
/db_xref="EnsemblGenomes-Gn:Rv3249c"
/db_xref="EnsemblGenomes-Tr:CCP46068"
/db_xref="GOA:O05892"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR040611"
/db_xref="PDB:5D1W"
/db_xref="UniProtKB/TrEMBL:O05892"
/protein_id="CCP46068.1"
/translation="MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAI
TLSDVARAAGISRQTIYNEFGSRQGLAQGYALRLADRLVDNVHASLDANVGNFYEAFL
QGFRSFFAESAADPLVISLLTGVAKPDLLQLITTDSAPIITRASARLAPAFTDTWVAT
TDNDANVLSRAIVRLCLSYVSMPPEADHDVAADLARLITPFAERHGVINVP"
gene complement(3630384..3630566)
/gene="rubB"
/locus_tag="Rv3250c"
CDS complement(3630384..3630566)
/codon_start=1
/transl_table=11
/gene="rubB"
/locus_tag="Rv3250c"
/product="Probable rubredoxin RubB"
/note="Rv3250c, (MTCY20B11.25c), len: 60 aa. Probable
rubB,rubredoxin, highly similar to other rubredoxins e.g.
Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA
scores: opt: 391, E(): 2.2e-21, (83.05% identity in 59 aa
overlap); Q9AE63|RUBA2 from Rhodococcus erythropolis (63
aa), FASTA scores: opt: 380, E(): 1.4e-20, (83.9% identity
in 56 aa overlap); P42453|RUBR_ACICA|RUBA from
Acinetobacter calcoaceticus (54 aa), FASTA scores: opt:
315, E(): 4.9e-16, (69.8% identity in 53 aa overlap);
Q9HTK7|PA5351 from Pseudomonas aeruginosa (55 aa), FASTA
scores: opt: 298, E(): 8e-15, (64.15% identity in 53 aa
overlap); Q9PGC3|XF0379 from Xylella fastidiosa (57
aa),FASTA scores: opt: 263, E(): 2.5e-12, (59.25% identity
in 54 aa overlap); etc. Also similar to neighbouring ORF
M. tuberculosis RubA (MTCY20B11.26c). Contains rubredoxin
signature (PS00202). Belongs to the rubredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv3250c"
/db_xref="EnsemblGenomes-Tr:CCP46069"
/db_xref="GOA:I6YFL7"
/db_xref="InterPro:IPR018527"
/db_xref="InterPro:IPR024934"
/db_xref="InterPro:IPR024935"
/db_xref="UniProtKB/TrEMBL:I6YFL7"
/inference="protein motif:PROSITE:PS00202"
/protein_id="CCP46069.1"
/translation="MNDYKLFRCIQCGFEYDEALGWPEDGIAAGTRWDDIPDDWSCPD
CGAAKSDFEMVEVARS"
gene complement(3630571..3630738)
/gene="rubA"
/locus_tag="Rv3251c"
CDS complement(3630571..3630738)
/codon_start=1
/transl_table=11
/gene="rubA"
/locus_tag="Rv3251c"
/product="Probable rubredoxin RubA"
/note="Rv3251c, (MTCY20B11.26c), len: 55 aa. Probable
rubA,rubredoxin, highly similar to other rubredoxins (but
sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus
erythropolis (61 aa), FASTA scores: opt: 335, E():
1e-17,(73.6% identity in 53 aa overlap);
P00272|RUB2_PSEOL|ALKG from Pseudomonas oleovorans (172
aa), FASTA scores: opt: 278, E(): 2.7e-13, (65.3% identity
in 49 aa overlap); CAC38028|ALKG from Alcanivorax
borkumensis (174 aa), FASTA scores: opt: 271, E():
8.6e-13, (62.0% identity in 50 aa overlap); Q9WWW4|ALKG
from Pseudomonas putida (175 aa),FASTA scores: opt: 270,
E(): 1e-12, (61.8% identity in 55 aa overlap); etc. Also
highly similar to C-terminus of Q9XBM1|ALKB alkane
1-monooxygenase from Prauserella rugosa (490 aa), FASTA
scores: opt: 296, E(): 2.9e-14, (75.5% identity in 49 aa
overlap). Also similar to neighbouring ORF Mycobacterium
tuberculosis rubB (MTCY20B11.25c). Contains rubredoxin
signature (PS00202). Belongs to the rubredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv3251c"
/db_xref="EnsemblGenomes-Tr:CCP46070"
/db_xref="GOA:O05894"
/db_xref="InterPro:IPR018527"
/db_xref="InterPro:IPR024934"
/db_xref="InterPro:IPR024935"
/db_xref="UniProtKB/TrEMBL:O05894"
/inference="protein motif:PROSITE:PS00202"
/protein_id="CCP46070.1"
/translation="MAAYRCPVCDYVYDEANGDAREGFPAGTGWDQIPDDWCCPDCAV
REKVDFEKIGG"
gene complement(3630738..3631988)
/gene="alkB"
/locus_tag="Rv3252c"
CDS complement(3630738..3631988)
/codon_start=1
/transl_table=11
/gene="alkB"
/locus_tag="Rv3252c"
/product="Probable transmembrane alkane 1-monooxygenase
AlkB (alkane 1-hydroxylase) (lauric acid
omega-hydroxylase) (omega-hydroxylase) (fatty acid
omega-hydroxylase) (alkane hydroxylase-rubredoxin)"
/note="Rv3252c, (MTCY20B11.27c), len: 416 aa. Probable
alkB, transmembrane alkane-1-monooxygenase, highly similar
to many (see Marin et al., 2001) e.g. Q9AE68|ALKB2 from
Rhodococcus erythropolis (408 aa), FASTA scores: opt:
2018,E(): 9.6e-122, (68.6% identity in 415 aa overlap);
Q9AFD5|ALKB from Nocardioides sp. CF8 (483 aa), FASTA
scores: opt: 1485, E(): 1.4e-87, (56.55% identity in 405
aa overlap); Q9XAU0|ALKB1 from Rhodococcus erythropolis
(391 aa), FASTA scores: opt: 1400, E(): 3.3e-82, (62.6%
identity in 396 aa overlap); Q9XBM1|ALKB from Prauserella
rugosa (490 aa), FASTA scores: opt: 1266, E(): 1.5e-73,
(57.55% identity in 410 aa overlap); CAC40954|ALKB4 from
Rhodococcus erythropolis (386 aa), FASTA scores: opt:
1190,E(): 9.1e-69, (54.3% identity in 383 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3252c"
/db_xref="EnsemblGenomes-Tr:CCP46071"
/db_xref="GOA:O05895"
/db_xref="InterPro:IPR005804"
/db_xref="InterPro:IPR033885"
/db_xref="UniProtKB/TrEMBL:O05895"
/protein_id="CCP46071.1"
/translation="MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLP
LIWGMNQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDKYYR
YCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSVGVLGGVGINTA
HEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRVSTPEDPASARFGETLWEFL
PRSVIGGLRSAVHLEAQRLRRLGVSPWNPMTYLRNDVLNAWLMSVVLWGGLIAVFGPA
LIPFVIIQAVFGFSLLEAVNYLEHYGLLRQKSANGRYERCAPVHSWNSDHIVTNLFLY
HLQRHSDHHANPTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYG
GDITRVNLHPRVREKALARYGASA"
gene complement(3632097..3633584)
/locus_tag="Rv3253c"
CDS complement(3632097..3633584)
/codon_start=1
/transl_table=11
/locus_tag="Rv3253c"
/product="Possible cationic amino acid transport integral
membrane protein"
/note="Rv3253c, (MTCY20B11.28c), len: 495 aa. Possible
cationic amino acid transporter, integral membrane
protein,similar to many e.g. O69844|SC1C3.02 putative
cationic amino acid transporter from Streptomyces
coelicolor (503 aa), FASTA scores: opt: 1649, E():
5.8e-92, (52.6% identity in 485 aa overlap); Q9AE69
putative transporter (fragment) from Rhodococcus
erythropolis (385 aa), FASTA scores: opt: 1594, E():
9.7e-89, (62.0% identity in 387 aa overlap); Q9PBD7|XF2207
cationic amino acid transporter from Xylella fastidiosa
(483 aa), FASTA scores: opt: 1079, E(): 1.2e-57,(40.55%
identity in 493 aa overlap); Q9SRU9|F20H23.25 putative
cationic amino acid transporter from Arabidopsis thaliana
(Mouse-ear cress) (614 aa), FASTA scores: opt: 802, E():
6.7e-41, (36.4% identity in 445 aa overlap);
P30823|CTR1_RAT|SLC7A1|ATRC1 high-affinity cationic amino
acid transporter-1 from Rattus norvegicus (Rat) (624
aa),FASTA scores: opt: 782, E(): 1.1e-39, (36.1% identity
in 432 aa overlap); etc. Relatives in Mycobacterium
tuberculosis include: MTCY3G12.14, E(): 5.6e-31;
MTCY39.19,E(): 1.6e-14. Seems to belong to the APC
family."
/db_xref="EnsemblGenomes-Gn:Rv3253c"
/db_xref="EnsemblGenomes-Tr:CCP46072"
/db_xref="GOA:O05896"
/db_xref="InterPro:IPR002293"
/db_xref="UniProtKB/TrEMBL:O05896"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46072.1"
/translation="MAGRRRMKSVEQSIADTDEPTTRLRKDLTWWDLVVFGVSVVIGA
GIFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVAGSAYTFSYATFG
EFLAWVIGWNLVLELAMGAAVVAKGWSSYLGTVFGFGNGTGHLGSLQLDWGALVIVTL
VATLIALGTKLSSRFSAVVTAIKVSVVVLVVVVGAFYIRAANYSPFIPEPEVQHHGGG
LDQSVFSLLTGAQGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGIL
ASLGVVTLLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGAL
AGLTTVVMVLMLGQCRVLFAMARDGLVPRQLAKTGSRGTPVRVTVLVAVLVATTASVF
PITKLEEMVNVGTLFAFILVSAGVVVLRRTRPDLQRGFTAPWVPLLPIAAVCACLWLM
LNLTALTWIRFGIWLVAGTAIYVGYGRRHSAQGLRQARESATRRC"
gene 3633675..3635063
/locus_tag="Rv3254"
CDS 3633675..3635063
/codon_start=1
/transl_table=11
/locus_tag="Rv3254"
/product="Conserved hypothetical protein"
/note="Rv3254, (MTCY20B11.29), len: 462 aa. Conserved
hypothetical protein, similar to CAC37877|SC1G7.02
putative secreted protein from Streptomyces coelicolor
(440 aa),FASTA scores: opt: 606, E(): 6.2e-31, (31.7%
identity in 445 aa overlap); O86550|SC1F2.13c hypothetical
50.7 KDA protein from Streptomyces coelicolor (476 aa),
FASTA scores: opt: 577, E(): 4.5e-29, (32.5% identity in
400 aa overlap); Q9L0A8|SCC24.09 putative secreted protein
from Streptomyces coelicolor (468 aa), FASTA scores: opt:
380,E(): 1.3e-16, (30.7% identity in 391 aa overlap);
BAB48792|MLL1411 probable FAD-dependent monooxygenase from
Rhizobium loti (Mesorhizobium loti) (421 aa), FASTA
scores: opt: 128, E(): 1.1, (25.2% identity in 397 aa
overlap); Q9L7X9|BENF benzoate-specific porin-like protein
from Pseudomonas putida (397 aa), FASTA scores: opt: 119,
E(): 4, (24.85% identity in 157 aa overlap); etc. Also
similar to N-terminus of AAK46259|MT1987 putative
ferredoxin reductase, electron transfer component from
Mycobacterium tuberculosis strain CDC1551 (839 aa), FASTA
scores: opt: 493, E(): 1.5e-23, (30.65% identity in 382 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3254"
/db_xref="EnsemblGenomes-Tr:CCP46073"
/db_xref="GOA:O05897"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:O05897"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46073.1"
/translation="MVIGASIAGLCAARVLSDFYSTVTVFERDELPEAPANRATVPQD
RHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENRPDCIYLGAAGHVLGTGHTLRKE
FTAYVPSRPHLEWQLRRRVLQLSNVQIVRRLVTEPQFERRQQRVVGVLLDSPGSGQDR
EREEFIAADLVVDAAGRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAE
KVVVAGASHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFTA
ALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGMTMTSLQ
AGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDISFHHATAEPLPRWWR
PAGSLFDQFLGAAETDPVLAEWFLRRFSLLDSLYMVPSVPIIGRAIAHNLRLWLKEQR
ERRQPVTTRRSP"
gene complement(3635041..3636267)
/gene="manA"
/locus_tag="Rv3255c"
CDS complement(3635041..3636267)
/codon_start=1
/transl_table=11
/gene="manA"
/locus_tag="Rv3255c"
/product="Probable mannose-6-phosphate isomerase ManA
(phosphomannose isomerase) (phosphomannoisomerase) (PMI)
(phosphohexoisomerase) (phosphohexomutase)"
/note="Rv3255c, (MTCY20B11.30c), len: 408 aa. Probable
manA, mannose-6-phosphate isomerase, equivalent to
Q9CCJ5|MANA|ML0765 putative mannose-6-phosphate isomerase
from Mycobacterium leprae (410 aa), FASTA scores: opt:
2271, E(): 1.6e-133, (84.45% identity in 411 aa overlap).
Also similar to many others e.g. Q9KZL9|MANA from
Streptomyces coelicolor (383 aa), FASTA scores: opt:
946,E(): 2.4e-51, (44.4% identity in 403 aa overlap);
Q9KV87|VC0269 from Vibrio cholerae (399 aa), FASTA scores:
opt: 726, E(): 1.1e-37, (34.15% identity in 404 aa
overlap); Q9CMJ5|PMI|PM0829 from Pasteurella multocida
(400 aa), FASTA scores: opt: 640, E(): 2.4e-32, (32.5%
identity in 391 aa overlap); etc. Similar to family 1 of
mannose-6-phosphate isomerases."
/db_xref="EnsemblGenomes-Gn:Rv3255c"
/db_xref="EnsemblGenomes-Tr:CCP46074"
/db_xref="GOA:O05898"
/db_xref="InterPro:IPR001250"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016305"
/db_xref="UniProtKB/TrEMBL:O05898"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46074.1"
/translation="MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGD
PAWLQTPHGQTSLLEALVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSA
EQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRA
LAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATE
FGAEAKTVLELGERYPGDAGVLAALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMA
NSDNVLRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLGLVFETPTDEFAATL
LVLDGDHLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIR
LTAGQPAKLFRATVGL"
gene complement(3636275..3637315)
/locus_tag="Rv3256c"
CDS complement(3636275..3637315)
/codon_start=1
/transl_table=11
/locus_tag="Rv3256c"
/product="Conserved protein"
/note="Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa.
Conserved protein, equivalent to Q9CCJ6|ML0764
hypothetical protein from Mycobacterium leprae (365 aa),
FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in
365 aa overlap). Also similar to other hypothetical
bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces
coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012,
(31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from
Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt:
140, E(): 0.84, (28.75% identity in 233 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3256c"
/db_xref="EnsemblGenomes-Tr:CCP46075"
/db_xref="GOA:O05899"
/db_xref="UniProtKB/TrEMBL:O05899"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46075.1"
/translation="MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEG
ELDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVL
IVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFG
LSRYLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGC
QLALAGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEID
GPAPQRLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRL
EMAAVYLRLVRG"
gene complement(3637312..3638709)
/gene="pmmA"
/locus_tag="Rv3257c"
CDS complement(3637312..3638709)
/codon_start=1
/transl_table=11
/gene="pmmA"
/locus_tag="Rv3257c"
/product="Probable phosphomannomutase PmmA (PMM)
(phosphomannose mutase)"
/note="Rv3257c, (MTV015.02c), len: 465 aa. Probable
pmmA,phosphomannomutase, equivalent to Q9CCJ7|PMMA|ML0763
phosphomannomutase from Mycobacterium leprae (468
aa),FASTA scores: opt: 2533, E(): 2e-145, (83.1% identity
in 468 aa overlap). Also similar to many e.g. Q9KZL6|MANB
from Streptomyces coelicolor (454 aa), FASTA scores: opt:
1820,E(): 2e-102, (63.2% identity in 459 aa overlap);
Q9PGN8|XF0260 from Xylella fastidiosa (500 aa), FASTA
scores: opt: 1085, E(): 4.7e-58, (40.7% identity in 462 aa
overlap); Q9EY19|MANB from Salmonella enterica subsp.
arizonae (456 aa), FASTA scores: opt: 988, E():
3.1e-52,(38.65% identity in 445 aa overlap); etc. Belongs
to the phosphohexose mutases family."
/db_xref="EnsemblGenomes-Gn:Rv3257c"
/db_xref="EnsemblGenomes-Tr:CCP46076"
/db_xref="GOA:O86374"
/db_xref="InterPro:IPR005841"
/db_xref="InterPro:IPR005843"
/db_xref="InterPro:IPR005844"
/db_xref="InterPro:IPR005845"
/db_xref="InterPro:IPR005846"
/db_xref="InterPro:IPR016055"
/db_xref="InterPro:IPR036900"
/db_xref="UniProtKB/TrEMBL:O86374"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46076.1"
/translation="MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRTE
DARPVVIGHDMRDSSPSLADAFAAGVTGQGLDVVRVGLASTDQLYFASGLLDCPGAMF
TASHNPAAYNGIKMCRAAAKPVGADTGLTAIRDDLIAGVARYDGTPGTIADQDVLVDY
GAFLRSLVDTSGLRPLRVAVDAGNGMAGHTAPAVLGVIDSITLLPSYFELDGSFPNHE
ANPLDPANLVDLQAYVRDTGADIGLAFDGDADRCFVVDERGQPVSPSTVTALVAAREL
NREIGATIIHNVITSRAVPELVAERGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHY
YFRDFWGADSGMLAALHVLAALGEQSRPLSELTADYQRYESSGEINFTVVDSSACVEA
VLKSFGNRIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVEGRSVGDVDAVVRQV
SAEIAAQSAHAKAGP"
gene complement(3638811..3639302)
/locus_tag="Rv3258c"
CDS complement(3638811..3639302)
/codon_start=1
/transl_table=11
/locus_tag="Rv3258c"
/product="Conserved hypothetical protein"
/note="Rv3258c, (MTV015.03c), len: 163 aa. Conserved
hypothetical protein, equivalent to Q9CCJ8|ML0762
hypothetical protein from Mycobacterium leprae (165
aa),FASTA scores: opt: 840, E(): 9.9e-42, (76.9% identity
in 169 aa overlap). Also similar to Q9KZL4|SCE34.11c
hypothetical 15.0 KDA protein from Streptomyces coelicolor
(140 aa), FASTA scores: opt: 353, E(): 1.1e-13, (48.3%
identity in 147 aa overlap); and shows really weak
similarity to other bacterial proteins."
/db_xref="EnsemblGenomes-Gn:Rv3258c"
/db_xref="EnsemblGenomes-Tr:CCP46077"
/db_xref="InterPro:IPR021888"
/db_xref="UniProtKB/TrEMBL:O53351"
/protein_id="CCP46077.1"
/translation="MRVSGASAALVHDSLSVVNVPRRCCRPGCPHYAVATLTFVYSDS
TAVIGPLATAREPHSWDLCVGHAGRITAPRGWELVRHAGPLPSHPDEDDLVALADAVR
EGGPSAGRRHHPGGNGAPLHGFDDFPAAATGAPTGGGVLAPPEPGAGRRRGHLRVLPD
PAD"
gene 3639425..3639844
/locus_tag="Rv3259"
CDS 3639425..3639844
/codon_start=1
/transl_table=11
/locus_tag="Rv3259"
/product="Conserved hypothetical protein"
/note="Rv3259, (MTV015.04), len: 139 aa. Conserved
hypothetical protein, equivalent, but shorter 29 aa, to
Q9CCJ9|ML0761 hypothetical protein from Mycobacterium
leprae (167 aa), FASTA scores: opt: 846, E():
2.2e-47,(89.2% identity in 139 aa overlap). C-terminus
highly similar to Q9S425 hypothetical 6.0 KDA protein
(fragment) from Mycobacterium smegmatis (54 aa), FASTA
scores: opt: 275, E(): 2.7e-11, (81.15% identity in 53 aa
overlap). Also similar to Q9KZL3|SCE34.12 from
Streptomyces coelicolor (117 aa), FASTA scores: opt: 152,
E(): 0.004, (34.15% identity in 126 aa overlap).
Equivalent to AAK47699 from Mycobacterium tuberculosis
strain CDC1551 (175 aa) but shorter 36 aa. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3259"
/db_xref="EnsemblGenomes-Tr:CCP46078"
/db_xref="InterPro:IPR010428"
/db_xref="InterPro:IPR038555"
/db_xref="UniProtKB/TrEMBL:O53352"
/protein_id="CCP46078.1"
/translation="MRGPLLPPTVPGWRSRAERFDMAVLEAYEPIERRWQERVSQLDI
AVDEIPRIAAKDPESVQWPPEVIADGPIALARLIPAGVDVRGNATRARIVLFRKPIER
RAKDTEELGELLHEILVAQVAIYLDVDPSVIDPTIDD"
gene complement(3639872..3640141)
/gene="whiB2"
/gene_synonym="whmD"
/locus_tag="Rv3260c"
CDS complement(3639872..3640141)
/codon_start=1
/transl_table=11
/gene="whiB2"
/gene_synonym="whmD"
/locus_tag="Rv3260c"
/product="Probable transcriptional regulatory protein
WhiB-like WhiB2"
/note="Rv3260c, (MTV015.05c), len: 89 aa. Probable whiB2
(alternate gene name: whmD), WhiB-like regulatory protein
(see Hutter & Dick 1999), similar to WhiB paralogue of
Streptomyces coelicolor, wblE gene product (85 aa).
Equivalent to Q9CCK0|WHIB2|ML0760 putative transcriptional
regulator from Mycobacterium leprae (89 aa), FASTA scores:
opt: 550, E(): 6.1e-31, (85.4% identity in 89 aa overlap).
Also similar to others e.g. Q9S426 WHMD regulatory protein
(see Gomez & Bishai 2000) from Mycobacterium smegmatis
(129 aa), FASTA scores: opt: 488, E(): 1.4e-26, (83.55%
identity in 85 aa overlap); Q06387|WHIB-STV WHIB-STV
protein from Streptomyces griseocarneus (87 aa), FASTA
scores: opt: 443,E(): 1.2e-23, (74.7% identity in 83 aa
overlap); Q05429|WHIB|WHIB1 transcription-like factor WhiB
from Streptomyces aureofaciens (87 aa), FASTA scores: opt:
442,E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc.
Equivalent to AAK47700 WhiB-related protein from
Mycobacterium tuberculosis strain CDC1551 (123 aa) but
shorter 34 aa. Also similar to other Mycobacterium
tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71
aa overlap) and MTCY78.13c (37.4% identity in 91 aa
overlap). Start chosen by homology but ORF continues to
ATG upstream at 3754."
/db_xref="EnsemblGenomes-Gn:Rv3260c"
/db_xref="EnsemblGenomes-Tr:CCP46079"
/db_xref="GOA:O53353"
/db_xref="InterPro:IPR003482"
/db_xref="InterPro:IPR034768"
/db_xref="UniProtKB/Swiss-Prot:O53353"
/protein_id="CCP46079.1"
/translation="MVPEAPAPFEEPLPPEATDQWQDRALCAQTDPEAFFPEKGGSTR
EAKKICMGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGII"
gene 3640543..3641538
/gene="fbiA"
/locus_tag="Rv3261"
CDS 3640543..3641538
/codon_start=1
/transl_table=11
/gene="fbiA"
/locus_tag="Rv3261"
/product="Probable F420 biosynthesis protein FbiA"
/note="Rv3261, (MTCY71.01), len: 331 aa. Probable
fbiA,F420 biosynthesis protein, equivalent to FBIA F420
biosynthesis protein fbiA from Mycobacterium bovis BCG
(see citations below). Also equivalent, but shorter 46 aa,
to Q9CCK1|ML0759 hypothetical protein from Mycobacterium
leprae (379 aa), FASTA scores: opt: 1855, E():
3.9e-110,(79.3% identity in 333 aa overlap). Also similar
to others e.g. Q9KZK9|SCE34.17 hypothetical 33.6 KDA
protein from Streptomyces coelicolor (319 aa), FASTA
scores: opt: 1151,E(): 1.2e-65, (55.1% identity in 332 aa
overlap); O29345|AF0917 conserved hypothetical protein
from Archaeoglobus fulgidus (296 aa), FASTA scores: opt:
469,E(): 1.7e-22, (31.15% identity in 302 aa overlap);
Q58653|MJ1256 hypothetical protein from Methanococcus
jannaschii (311 aa), FASTA scores: opt: 436, E():
2.2e-20,(27.35% identity in 274 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3261"
/db_xref="EnsemblGenomes-Tr:CCP46080"
/db_xref="GOA:P9WP81"
/db_xref="InterPro:IPR002882"
/db_xref="InterPro:IPR010115"
/db_xref="UniProtKB/Swiss-Prot:P9WP81"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46080.1"
/translation="MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAV
VNVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWF
ELGDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPV
DESRKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVV
SIGAILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHY
GARCATGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA"
gene 3641535..3642881
/gene="fbiB"
/locus_tag="Rv3262"
CDS 3641535..3642881
/codon_start=1
/transl_table=11
/gene="fbiB"
/locus_tag="Rv3262"
/product="Probable F420 biosynthesis protein FbiB"
/note="Rv3262, (MTCY71.02), len: 448 aa. Probable
fbiB,F420 biosynthesis protein, equivalent to FBIB F420
biosynthesis protein fbiB from Mycobacterium bovis BCG
(see citations below). Also equivalent to Q9CCK2|ML0758
putative oxidoreductase from Mycobacterium leprae (457
aa), FASTA scores: opt: 2411, E(): 3.5e-137, (82.25%
identity in 445 aa overlap). Also similar to
Q9KZK8|SCE34.18 putative oxidoreductase from Streptomyces
coelicolor (443 aa), FASTA scores: opt: 1180, E():
2.2e-63, (51.75% identity in 433 aa overlap); other
oxidoreductases in C-terminus; and several hypothetical
bacterial proteins."
/db_xref="EnsemblGenomes-Gn:Rv3262"
/db_xref="EnsemblGenomes-Tr:CCP46081"
/db_xref="GOA:P9WP79"
/db_xref="InterPro:IPR000415"
/db_xref="InterPro:IPR002847"
/db_xref="InterPro:IPR008225"
/db_xref="InterPro:IPR019943"
/db_xref="InterPro:IPR023661"
/db_xref="InterPro:IPR029479"
/db_xref="PDB:4XOM"
/db_xref="PDB:4XOO"
/db_xref="PDB:4XOQ"
/db_xref="UniProtKB/Swiss-Prot:P9WP79"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46081.1"
/translation="MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGD
VVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLGLV
QAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITDTMGRAWRNGQ
TDAAVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAAAADLVKGKLTATPVAVVR
GFGVSDDGSTARQLLRPGANDLFWLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLV
EAAVAEALTAPAPHHTRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERR
VARGQILYDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRG
LGSCWIGSTIFAADLVRDELDLPVDWEPLGAIAIGYADEPSGLRDPVPAADLLILK"
gene 3643177..3644838
/locus_tag="Rv3263"
CDS 3643177..3644838
/codon_start=1
/transl_table=11
/locus_tag="Rv3263"
/product="Probable DNA methylase (modification methylase)
(methyltransferase)"
/note="Rv3263, (MTCY71.03), len: 553 aa. Probable DNA
methylase, equivalent to Q9CCK4|ML0756 probable DNA
methylase from Mycobacterium leprae (555 aa), FASTA
scores: opt: 2980, E(): 2.1e-184, (81.9% identity in 541
aa overlap). Also similar to others e.g.
P25240|MT57_ECOLI|ECO57IM modification methylase from
Escherichia coli (544 aa), FASTA scores: opt: 595, E():
1e-30, (30.35% identity in 507 aa overlap);
P25201|MTA1_ACICA|ACCIM modification methylase ACCI from
Acinetobacter calcoaceticus (540 aa), FASTA scores: opt:
366, E(): 5.7e-16, (23.35% identity in 467 aa overlap);
Q56752|M-ACCI ACCI methylase from Bergeyella zoohelcum
(541 aa), FASTA scores: opt: 365, E(): 6.6e-16, (22.95%
identity in 466 aa overlap); etc. Contains PS00092 N-6
Adenine-specific DNA methylases signature. Alternative
start site at aa 25."
/db_xref="EnsemblGenomes-Gn:Rv3263"
/db_xref="EnsemblGenomes-Tr:CCP46082"
/db_xref="GOA:P96868"
/db_xref="InterPro:IPR002052"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:P96868"
/inference="protein motif:PROSITE:PS00092"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46082.1"
/translation="MQPSHPTRPGAVIRYVGSSLDTCPMTTFAGKTAASADKVRGGYY
TPPAVARFLAHWVHQAGPKILEPSCGDGRILRELSAITDHAHGVELVAREAKKSRDFA
SVDTENLFTWLHKTQLGSWDGVAGNPPYIRFGNWASEQRDPALELMRRVGLRPTKLTN
AWVPFVVASTTLARDGGRVGLVVPAELLQVTYAAQLREFLLSRYREITLVTFERLVFD
GILQEVVLFCGVVGPGPAHIRTVRLGDANDLNALGDKDFTNESAPALLHEKEKWTKYF
LDPAQIRLLRGLKQSATMIRLGELADVDVGIVTGRNSFFTFTDAKAQALGLRAHCVPL
VSRSAQLSGLIYDEDCRACDVAGNHRTWLLDAADYPTDPALVAHITAGEAAGVHLGYK
CSIRKPWWSTPSLWMPDLFMLRQIHFAPRLTVNAAAATSTDTVHRVRLDPNVDPATLA
AVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPMPPPAYGSAELAQDVDLLLKANE
IDKALDVVDRHVLIDGLGLSPRLVAGCRAAWLTLRDRRTKRGSRR"
gene complement(3644898..3645977)
/gene="manB"
/gene_synonym="hddC"
/locus_tag="Rv3264c"
CDS complement(3644898..3645977)
/codon_start=1
/transl_table=11
/gene="manB"
/gene_synonym="hddC"
/locus_tag="Rv3264c"
/product="D-alpha-D-mannose-1-phosphate
guanylyltransferase ManB (D-alpha-D-heptose-1-phosphate
guanylyltransferase)"
/note="Rv3264c, (MTCY71.04c), len: 359 aa. ManB (alternate
gene name: hddC), D-alpha-D-mannose-1-phosphate
guanylyltransferase (see citations below), equivalent to
Q9CCK6|RMLA2|ML0753 putative sugar-phosphate nucleotidyl
transferase from Mycobacterium leprae (358 aa), FASTA
scores: opt: 2075, E(): 2.7e-115, (86.9% identity in 359
aa overlap). Also similar to others e.g. Q9KZK6|SCE34.20c
putative nucleotide phosphorylase from Streptomyces
coelicolor (360 aa), FASTA scores: opt: 1314, E():
2.2e-70,(57.0% identity in 358 aa overlap);
Q9KZP4|SC1A8A.08 putative mannose-1-phosphate
guanyltransferase from Streptomyces coelicolor (831 aa),
FASTA scores: opt: 699,E(): 8.6e-34, (34.45% identity in
354 aa overlap) (only similarity in N-terminus for this
one); P74589|SLL1496 mannose-1-phosphate guanyltransferase
from Synechocystis sp. strain PCC 6803 (843 aa), FASTA
scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa
overlap) (only similarity in N-terminus for this one too);
BAB59222|TVG0079558 mannose-1-phosphate guanyltransferase
from Thermoplasma volcanium (359 aa), FASTA scores: opt:
664, E(): 5.2e-32, (34.6% identity in 338 aa overlap);
Q9ZTW5|GMP GDP-mannose pyrophosphorylase from Solanum
tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E():
2.3e-30, (34.65% identity in 361 aa overlap); etc. Belongs
to family 2 of mannose-6-phosphate isomerases. Note that
previously known as rmlA2."
/db_xref="EnsemblGenomes-Gn:Rv3264c"
/db_xref="EnsemblGenomes-Tr:CCP46083"
/db_xref="GOA:L7N6A5"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR005835"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:L7N6A5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46083.1"
/translation="MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLS
RIAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLR
NDTAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAF
LEKTEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDAS
YWRDMGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRG
AEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVIGDGADIGARC
ELLSGARVWPGVFLPDGGIRYSSDV"
gene complement(3645979..3646884)
/gene="wbbL1"
/gene_synonym="wbbL"
/locus_tag="Rv3265c"
CDS complement(3645979..3646884)
/codon_start=1
/transl_table=11
/gene="wbbL1"
/gene_synonym="wbbL"
/locus_tag="Rv3265c"
/product="dTDP-RHA:a-D-GlcNAc-diphosphoryl
polyprenol,a-3-L-rhamnosyl transferase WbbL1
(alpha-L-rhamnose-(1->3)-alpha-D-GlcNAc(1->P)-P-
decaprenyl)"
/note="Rv3265c, (MTCY71.05c), len: 301 aa.
wbbL1,dTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol
a-3-L-rhamnosyl transferase (see citations below),
equivalent to Q9CCK7|WBBL|ML0752 putative dTDP-rhamnosyl
transferase from Mycobacterium leprae (308 aa), FASTA
scores: opt: 1788,E(): 3e-104, (85.05% identity in 301 aa
overlap); and Q9RN50|WBBL|Q9RN49 (see note * below)
dTDP-RHA:a-D-GlcNAc-diphosphoryl
polyprenol,a-3-L-rhamnosyl transferase from Mycobacterium
smegmatis (296 aa), FASTA scores: opt: 1494, E(): 6.1e-86,
(72.35% identity in 293 aa overlap). Note that previously
known as wbbL. [* Note: unpublished (experimental study on
Mycobacterium smegmatis). Submitted (SEP-1999) to the
EMBL/GenBank/DDBJ databases - The cell wall
arabinogalactan linker formation enzyme,
dTDP-Rha:a-D-GlcNAc-diphosphoryl polyprenol,
a-3-L-rhamnosyl transferase is essential for mycobacterial
viability - Mills J.A., Motichka K., Jucker M., Wu H.P.,
Uhlic B.C., Stern R.J., Scherman M.S., Vissa V.D., Yan W.,
Pan F., Kimbrel S., Kundu M., McNeil M.]."
/db_xref="EnsemblGenomes-Gn:Rv3265c"
/db_xref="EnsemblGenomes-Tr:CCP46084"
/db_xref="GOA:P9WMY3"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WMY3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46084.1"
/translation="MVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAA
VQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGS
IDALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTT
AYRQERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWL
SVYVPSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLAL
RSHLMVRSSLRRSRRRKLKLVEGRH"
gene complement(3646895..3647809)
/gene="rmlD"
/locus_tag="Rv3266c"
CDS complement(3646895..3647809)
/codon_start=1
/transl_table=11
/gene="rmlD"
/locus_tag="Rv3266c"
/product="dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD
(dTDP-rhamnose modification protein) (dTDP-rhamnose
biosynthesis protein) (dTDP-rhamnose synthase)"
/note="Rv3266c, (MTCY71.06c), len: 304 aa.
RmlD,dTDP-6-deoxy-L-lyxo-4-hexulose reductase
(dTDP-rhamnose modification protein) (see citations
below), highly similar to Q9CCK8 putative dTDP-rhamnose
modification protein from Mycobacterium leprae (311 aa),
FASTA scores, opt: 1440,E(): 1.1e-78, (74.7% identity in
312 aa overlap); and similar to several
dTDP-4-dehydrorhamnose reductase e.g. STRL_STRGR|P29781
from Streptomyces griseus (304 aa), FASTA scores, opt:
788, E(): 0, (47.4% identity in 304 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3266c"
/db_xref="EnsemblGenomes-Tr:CCP46085"
/db_xref="GOA:P9WH09"
/db_xref="InterPro:IPR005913"
/db_xref="InterPro:IPR029903"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WH09"
/protein_id="CCP46085.1"
/translation="MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITD
PAAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHV
STDYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYT
GGTGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAAN
EGVVSRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLR
HWRSALATALAAPANSTSIDRRLPSTRD"
gene 3647885..3649381
/locus_tag="Rv3267"
CDS 3647885..3649381
/codon_start=1
/transl_table=11
/locus_tag="Rv3267"
/product="Conserved protein (CPSA-related protein)"
/note="Rv3267, (MTCY71.07), len: 498 aa. Conserved
protein,CPSA-related protein, equivalent to Q9CCK9|ML0750
hypothetical protein from Mycobacterium leprae (489
aa),FASTA scores: opt: 2523, E(): 5e-138, (78.9% identity
in 498 aa overlap); and Q50160|CPSA (hypothetical protein
CPSA) from Mycobacterium leprae (516 aa), FASTA scores:
opt: 868, E(): 1.2e-42, (34.7% identity in 507 aa
overlap). Also similar to O06347|CPSA|Rv3484|MTCY13E12.37
CPSA from Mycobacterium tuberculosis (512 aa), FASTA
scores: opt: 928, E(): 4.2e-46, (37.35% identity in 498 aa
overlap); and O53834|Rv0822c|MTV043.14c hypothetical 72.9
KDA protein from Mycobacterium tuberculosis (684 aa),
FASTA scores: opt: 434, E(): 1.5e-17, (30.9% identity in
541 aa overlap). Also similar to Q9KZK0|SCE34.26 conserved
hypothetical protein from Streptomyces coelicolor (507
aa), FASTA scores: opt: 437, E(): 8.1e-18, (28.55%
identity in 469 aa overlap); O68907 FRNA protein from
Streptomyces roseofulvus (770 aa), FASTA scores: opt: 388,
E(): 7.6e-15, (32.6% identity in 267 aa overlap); etc.
Contains PS00017 ATP/GTP-binding site motif A. Predicted
to be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3267"
/db_xref="EnsemblGenomes-Tr:CCP46086"
/db_xref="GOA:P96872"
/db_xref="InterPro:IPR004474"
/db_xref="InterPro:IPR027381"
/db_xref="UniProtKB/TrEMBL:P96872"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46086.1"
/translation="MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIF
HMSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILI
RVPNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAA
GTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGAD
FPAGRQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLK
RLEQAVQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVD
PRQVQDWVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTT
GSVGNNDGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYS
GPGSGLGGSDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN"
gene 3649420..3650109
/locus_tag="Rv3268"
CDS 3649420..3650109
/codon_start=1
/transl_table=11
/locus_tag="Rv3268"
/product="Conserved hypothetical protein"
/note="Rv3268, (MTCY71.08), len: 229 aa. Conserved
hypothetical protein, similar to Q9KZK4|SCE34.22
hypothetical 27.1 KDA protein from Streptomyces coelicolor
(263 aa), FASTA scores: opt: 442, E(): 5.9e-20, (40.1%
identity in 242 aa overlap). Also weak similarity to
N-terminal part (approximately 1530 to 1740 residues) of
O07944|SNBDE pristinamycin I synthase 3 and 4 from
Streptomyces pristinaespiralis (4848 aa), FASTA scores:
opt: 159, E(): 0.11, (30.35% identity in 224 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3268"
/db_xref="EnsemblGenomes-Tr:CCP46087"
/db_xref="InterPro:IPR017523"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/TrEMBL:P96873"
/protein_id="CCP46087.1"
/translation="MLRADPVGPRITYYDDATGERIELSAVTLANWAAKTGNLLRDEL
AAGPASRVAILLPAHWQTAAVLFGVWWIGAQAILDDSPADVALCTADRLAEADAVVNS
AAVAGEVAVLSLDPFGRPATGLPVGVTDYATAVRVHGDQIVPEHNPGPVLAGRSVEQI
LRDCAASAAARGLTAADRVLSTASWAGPDELVDGLLAILAAGASLVQVANPDPAMLQR
RIATEKVTRVL"
gene 3650234..3650515
/locus_tag="Rv3269"
CDS 3650234..3650515
/codon_start=1
/transl_table=11
/locus_tag="Rv3269"
/product="Conserved protein"
/note="Rv3269, (MTCY71.09), len: 93 aa. Conserved
protein,similar to many Mycobacterium proteins and
chaperonins/heat shock proteins e.g. Q9CCL0|ML0748
hypothetical protein from Mycobacterium leprae (92 aa),
FASTA scores: opt: 427, E(): 6.8e-21, (73.65% identity in
91 aa overlap); Q10865|Rv1993c|MT2049|MTCY39.26c
hypothetical protein from Mycobacterium tuberculosis (90
aa), FASTA scores: opt: 313,E(): 1.2e-13, (60.7% identity
in 84 aa overlap); P71542|Y968_MYCTU|Rv0968|MTCY10D7.06c
(98 aa), FASTA scores: opt: 294, E(): 2.2e-12, (55.1%
identity in 98 aa overlap); Q50827|MOPA|GROEL|CH60_MYCVA
chaperonin (protein CPN60) from Mycobacterium vaccae (120
aa), FASTA scores: opt: 107, E(): 2.1, (39.5% identity in
81 aa overlap); Q9AEB3|HSP65 heat shock protein (fragment)
from Mycobacterium gadium (122 aa), FASTA scores: opt:
102, E(): 4.4, (38.25% identity in 81 aa overlap);
Q49374|CH60_MYCGN|MOPA|GROEL chaperonin (protein CPN60)
from Mycobacterium genavense (120 aa), FASTA scores: opt:
99, E(): 6.8, (40.25% identity in 82 aa overlap); etc. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3269"
/db_xref="EnsemblGenomes-Tr:CCP46088"
/db_xref="GOA:P96874"
/db_xref="InterPro:IPR009963"
/db_xref="UniProtKB/TrEMBL:P96874"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46088.1"
/translation="MAIQVFLAKATTTVITGLAGVTAYEILKKAAAKAPLRQTAVSAA
ALGLRGTRKAEEAAESARLKVADVMAEARERIGEESPTPAISDLHDHDH"
gene 3650526..3652682
/gene="ctpC"
/locus_tag="Rv3270"
CDS 3650526..3652682
/codon_start=1
/transl_table=11
/gene="ctpC"
/locus_tag="Rv3270"
/product="Probable metal cation-transporting P-type ATPase
C CtpC"
/note="Rv3270, (MT3370, MTCY71.10), len: 718 aa. Probable
ctpC, metal cation-transport ATPase P-type, integral
membrane protein, equivalent to Q9CCL1|CTPC|ML0747
putative cation transport ATPase from Mycobacterium leprae
(725 aa),FASTA scores: opt: 3908, E(): 0, (85.95% identity
in 713 aa overlap). Also similar to O66027|MTAA metal
transporting ATPase MTA72 from Mycobacterium tuberculosis
(680 aa),FASTA scores: opt: 3756, E(): 5.5e-213, (91.45%
identity in 679 aa overlap); and to other ATPases e.g.
Q9ZHC7|SILP_SALTY putative cation transporting P-type
ATPase from Salmonella typhimurium (824 aa), FASTA scores:
opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa
overlap); Q9HX93|PA3920 probable metal transporting P-type
ATPase from Pseudomonas aeruginosa (792 aa), FASTA scores:
opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa
overlap); etc. Contains PS00154 E1-E2 ATPases
phosphorylation site. Belongs to the cation transport
ATPases family (E1-E2 ATPases), subfamily IB."
/db_xref="EnsemblGenomes-Gn:Rv3270"
/db_xref="EnsemblGenomes-Tr:CCP46089"
/db_xref="GOA:P9WPT5"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR027256"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPT5"
/inference="protein motif:PROSITE:PS00154"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46089.1"
/translation="MTLEVVSDAAGRMRVKVDWVRCDSRRAVAVEEAVAKQNGVRVVH
AYPRTGSVVVWYSPRRADRAAVLAAIKGAAHVAAELIPARAPHSAEIRNTDVLRMVIG
GVALALLGVRRYVFARPPLLGTTGRTVATGVTIFTGYPFLRGALRSLRSGKAGTDALV
SAATVASLILRENVVALTVLWLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWVRLTD
PSAGSDAATEIQVPIDTVQIGDEVVVHEHVAIPVDGEVVDGEAIVNQSAITGENLPVS
VVVGTRVHAGSVVVRGRVVVRAHAVGNQTTIGRIISRVEEAQLDRAPIQTVGENFSRR
FVPTSFIVSAIALLITGDVRRAMTMLLIACPCAVGLSTPTAISAAIGNGARRGILIKG
GSHLEQAGRVDAIVFDKTGTLTVGRPVVTNIVAMHKDWEPEQVLAYAASSEIHSRHPL
AEAVIRSTEERRISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLRAEKVRVSKKAS
EWVDKLRRQAETPLLLAVDGTLVGLISLRDEVRPEAAQVLTKLRANGIRRIVMLTGDH
PEIAQVVADELGIDEWRAEVMPEDKLAAVRELQDDGYVVGMVGDGINDAPALAAADIG
IAMGLAGTDVAVETADVALANDDLHRLLDVGDLGERAVDVIRQNYGMSIAVNAAGLLI
GAGGALSPVLAAILHNASSVAVVANSSRLIRYRLDR"
gene complement(3652679..3653347)
/locus_tag="Rv3271c"
CDS complement(3652679..3653347)
/codon_start=1
/transl_table=11
/locus_tag="Rv3271c"
/product="Probable conserved integral membrane protein"
/note="Rv3271c, (MTCY71.11c), len: 222 aa. Probable
conserved integral membrane protein, similar to others
e.g. Q9RD35|SCM1.07c from Streptomyces coelicolor (230
aa),FASTA scores: opt: 360, E(): 4.7e-16, (33.85% identity
in 195 aa overlap); Q9X897|SCE2.02c from Streptomyces
coelicolor (234 aa), FASTA scores: opt: 357, E():
7.3e-16,(33.85% identity in 195 aa overlap); Q9D0E0
2610024A01RIK protein from Mus musculus (Mouse) (288 aa),
FASTA scores: opt: 191, E(): 3.7e-05, (23.65% identity in
207 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3271c"
/db_xref="EnsemblGenomes-Tr:CCP46090"
/db_xref="GOA:P96876"
/db_xref="InterPro:IPR002524"
/db_xref="InterPro:IPR026765"
/db_xref="InterPro:IPR027469"
/db_xref="UniProtKB/TrEMBL:P96876"
/protein_id="CCP46090.1"
/translation="METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLL
TEGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVA
VSFWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSG
ATAGEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGH
GCGC"
gene 3653448..3654632
/locus_tag="Rv3272"
CDS 3653448..3654632
/codon_start=1
/transl_table=11
/locus_tag="Rv3272"
/product="Conserved hypothetical protein"
/note="Rv3272, (MTCY71.12), len: 394 aa. Conserved
hypothetical protein, similar to various proteins e.g.
Q9I672|PA0446 hypothetical protein from Pseudomonas
aeruginosa (407 aa), FASTA scores: opt: 643, E():
6.8e-32,(33.15% identity in 389 aa overlap);
Q9RJU8|SCF41.21 putative racemase from Streptomyces
coelicolor (403 aa),FASTA scores: opt: 541, E(): 1.1e-25,
(31.95% identity in 385 aa overlap); O87838|SC8A6.04c
putative transferase from Streptomyces coelicolor (410
aa), FASTA scores: opt: 539,E(): 1.5e-25, (29.95% identity
in 395 aa overlap); Q9I563|PA0882 from Pseudomonas
aeruginosa (400 aa), FASTA scores: opt: 530, E(): 5.2e-25,
(28.8% identity in 396 aa overlap); BAB60328|TVG1215416
L-carnitine dehydratase from Thermoplasma volcanium (399
aa), FASTA scores: opt: 529,E(): 6e-25, (32.9% identity in
383 aa overlap); etc. C-terminus is similar to
Q49678|U00012_27|B1308_C3_195 from Mycobacterium leprae
(130 aa) (60.0% identity in 115 aa overlap). Also
partially similar to MTCY359_7 from M. tuberculosis (778
aa) (29.9% identity in 388 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3272"
/db_xref="EnsemblGenomes-Tr:CCP46091"
/db_xref="GOA:P96877"
/db_xref="InterPro:IPR003673"
/db_xref="InterPro:IPR023606"
/db_xref="PDB:5YIT"
/db_xref="PDB:5YIY"
/db_xref="PDB:5YX6"
/db_xref="UniProtKB/Swiss-Prot:P96877"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46091.1"
/translation="MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP
GGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEA
FRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEAGMTTGMP
TPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQANQL
MMHLNRAASDQPKPEPAPKAKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCY
LIGRPDLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHT
WKQVVDTPLFAENDLTLEVGRGADTITVIRTPARYASFRAVVTDPPPTAGEHNAVFLA
RP"
gene 3654637..3656931
/locus_tag="Rv3273"
CDS 3654637..3656931
/codon_start=1
/transl_table=11
/locus_tag="Rv3273"
/product="Probable transmembrane carbonic anhydrase
(carbonate dehydratase) (carbonic dehydratase)"
/note="Rv3273, (MTCY71.13), len: 764 aa. Probable
transmembrane protein (N-terminal part is hydrophobic)
with probable carbonic anhydrase activity (in C-terminal
part). Possibly involved in transport of sulfate.
Equivalent to Q9CBA3|ML2279 putative transmembrane
transport protein from Mycobacterium leprae (496 aa),
FASTA scores: opt: 1637,E(): 1.8e-89, (59.15% identity in
487 aa overlap). Similar to various proteins (principally
sulfate transporters) e.g. Q9X927|SCH5.25 putative
integral membrane protein from Streptomyces coelicolor
(830 aa), FASTA scores: opt: 1325,E(): 8e-71, (40.85%
identity in 788 aa overlap); Q9I729|PA0103 probable
sulfate transporter from Pseudomonas aeruginosa (523 aa),
FASTA scores: opt: 1015, E(): 1.3e-52,(39.95% identity in
488 aa overlap); Q9KN88|VCA0077 sulfate permease family
protein from Vibrio cholerae (553 aa),FASTA scores: opt:
629, E(): 9.6e-30, (30.95% identity in 423 aa overlap);
etc. C-terminal part (aa 550-764) shows similarity to
carbonic anhydrase e.g. P27134|CYNT_SYNP7 carbonic
anhydrase (272 aa), FASTA scores: opt: 350, E(): 8.1e-15,
(33.8% identity in 201 aa overlap). Contains PS00704
Prokaryotic-type carbonic anhydrases signature 1. Seems to
belong to the SulP family."
/db_xref="EnsemblGenomes-Gn:Rv3273"
/db_xref="EnsemblGenomes-Tr:CCP46092"
/db_xref="GOA:P96878"
/db_xref="InterPro:IPR001765"
/db_xref="InterPro:IPR001902"
/db_xref="InterPro:IPR011547"
/db_xref="InterPro:IPR015892"
/db_xref="InterPro:IPR036874"
/db_xref="UniProtKB/TrEMBL:P96878"
/inference="protein motif:PROSITE:PS00704"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46092.1"
/translation="MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLV
ALPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDEL
GWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGG
TSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGA
TVLALLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIAS
VESLLSAVGVDKLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIVRSSANVAAGA
RTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNF
VIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDG
TLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVE
TSPAKLHHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHP
HIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAA
LDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHP
ARRSAESAGYPEADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVY
EVGPNGIICPDEPADRPVDHESAQ"
gene complement(3656920..3658089)
/gene="fadE25"
/locus_tag="Rv3274c"
CDS complement(3656920..3658089)
/codon_start=1
/transl_table=11
/gene="fadE25"
/locus_tag="Rv3274c"
/product="Probable acyl-CoA dehydrogenase FadE25"
/note="Rv3274c, (MTCY71.14c), len: 389 aa. Probable
fadE25,Acyl-CoA Dehydrogenase, equivalent to
P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 probable
acyl-CoA dehydrogenase FADE25 from Mycobacterium leprae
(389 aa), FASTA scores: opt: 2394, E(): 3.8e-143, (92.05%
identity in 389 aa overlap). Also similar to many e.g.
Q9RIQ5|fade fatty acid acyl-CoA dehydrogenase from
Streptomyces lividans (385 aa), FASTA scores: opt:
1692,E(): 4.9e-99, (67.35% identity in 383 aa overlap);
P45867|ACDA_BACSU|ACD from Bacillus subtilis (379
aa),FASTA scores: opt: 1212, E(): 7.2e-69, (51.85%
identity in 376 aa overlap); Q9K6D1|ACDA|BH3798 from
Bacillus halodurans (380 aa), FASTA scores: opt: 1209,
E(): 1.1e-68,(51.7% identity in 377 aa overlap);
P52042|ACDS_CLOAB|BCD from Clostridium acetobutylicum (379
aa), FASTA scores: opt: 1056, E(): 4.6e-59, (44.6%
identity in 379 aa overlap); etc. Contains PS00072
Acyl-CoA dehydrogenases signature 1, PS00073 Acyl-CoA
dehydrogenases signature 2. Belongs to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3274c"
/db_xref="EnsemblGenomes-Tr:CCP46093"
/db_xref="GOA:P9WQG1"
/db_xref="InterPro:IPR006089"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/Swiss-Prot:P9WQG1"
/inference="protein motif:PROSITE:PS00073"
/inference="protein motif:PROSITE:PS00072"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46093.1"
/translation="MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEK
ARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVNKL
GTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILN
GAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPT
TELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKD
RKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFAS
DVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR"
gene complement(3658114..3658638)
/gene="purE"
/locus_tag="Rv3275c"
CDS complement(3658114..3658638)
/codon_start=1
/transl_table=11
/gene="purE"
/locus_tag="Rv3275c"
/product="Probable phosphoribosylaminoimidazole
carboxylase catalytic subunit PurE (air carboxylase)
(AIRC)"
/note="Rv3275c, (MTCY71.15c, PUR6), len: 174 aa. Probable
purE, phosphoribosylaminoimidazole carboxylase catalytic
subunit, equivalent to
P46702|PUR6_MYCLE|pure|ML0736|B1308_F3_98 from
Mycobacterium leprae (171 aa), FASTA scores: opt: 878,
E(): 1.5e-43, (81.55% identity in 168 aa overlap). Also
similar to others e.g. Q9AXD0|AIRC from Nicotiana tabacum
(Common tobacco) (623 aa), FASTA scores: opt: 712, E():
1.4e-33,(69.35% identity in 160 aa overlap) (similarity in
C-terminal part for this one); Q44679|PUR6_CORAM from
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
(177 aa), FASTA scores: opt: 651, E(): 1.5e-30, (68.25%
identity in 148 aa overlap);
Q55498|PUR6_SYNY3|pure|SLL0901 from Synechocystis sp.
strain PCC 6803 (176 aa), FASTA scores: opt: 639, E():
7.1e-30, (60.5% identity in 167 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3275c"
/db_xref="EnsemblGenomes-Tr:CCP46094"
/db_xref="GOA:P9WHM1"
/db_xref="InterPro:IPR000031"
/db_xref="InterPro:IPR024694"
/db_xref="InterPro:IPR033747"
/db_xref="InterPro:IPR035893"
/db_xref="PDB:3LP6"
/db_xref="UniProtKB/Swiss-Prot:P9WHM1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46094.1"
/translation="MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSA
HRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLD
SLLSIVQMPAGVPVATVSIGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAK
DAELQRLAGKLTRD"
gene complement(3658635..3659924)
/gene="purK"
/locus_tag="Rv3276c"
CDS complement(3658635..3659924)
/codon_start=1
/transl_table=11
/gene="purK"
/locus_tag="Rv3276c"
/product="Probable phosphoribosylaminoimidazole
carboxylase ATPase subunit PurK (air carboxylase) (AIRC)"
/note="Rv3276c, (MTCY71.16c), len: 429 aa. Probable
purK,phosphoribosylaminoimidazole carboxylase ATPase
subunit ,equivalent to
P46701|PURK_MYCLE|ML0735|B1308_F1_32
phosphoribosylaminoimidazole carboxylase ATPase subunit
from Mycobacterium leprae (439 aa), FASTA scores: opt:
2168, E(): 2.3e-123, (76.15% identity in 444 aa overlap).
Also similar to others e.g. Q44678|PURK_CORAM from
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
(413 aa), FASTA scores: opt: 1179, E(): 9.1e-64, (48.35%
identity in 389 aa overlap); Q9KZ85|PURK from Streptomyces
coelicolor (368 aa), FASTA scores: opt: 1150, E():
4.7e-62,(55.35% identity in 345 aa overlap);
Q54975|PURK_SYNP7 from Synechococcus sp. strain PCC 7942
(Anacystis nidulans R2) (395 aa), FASTA scores: opt: 772,
E(): 3e-39, (38.1% identity in 383 aa overlap); etc.
Belongs to the PurK / PurT family."
/db_xref="EnsemblGenomes-Gn:Rv3276c"
/db_xref="EnsemblGenomes-Tr:CCP46095"
/db_xref="GOA:P9WHL9"
/db_xref="InterPro:IPR003135"
/db_xref="InterPro:IPR005875"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR013815"
/db_xref="InterPro:IPR016185"
/db_xref="InterPro:IPR040686"
/db_xref="UniProtKB/Swiss-Prot:P9WHL9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46095.1"
/translation="MMAVASSRTPAVTSFIAPLVAMVGGGQLARMTHQAAIALGQNLR
VLVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGADVLTFDHEHVPNELLEKLVADGV
NVAPSPQALVHAQDKLVMRQRLAAAGVAVPRYAGIKDPDEIDVFAARVDAPIVVKAVR
GGYDGRGVRMARDVADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAW
PVVQTVQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETTDGA
LLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPVTVMANVLGAAQ
PPAMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGSDVAQLCERAELAAHW
LSHGRWTDGWDPHRASDDAVGVPPACGGRSDEEERRL"
repeat_region complement(3658658..3658715)
/gene="purK"
/locus_tag="Rv3276c"
/note="58 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene 3659878..3660696
/locus_tag="Rv3277"
CDS 3659878..3660696
/codon_start=1
/transl_table=11
/locus_tag="Rv3277"
/product="Probable conserved transmembrane protein"
/note="Rv3277, (MTCY71.17), len: 272 aa. Probable
conserved transmembrane protein, equivalent, but longer 49
aa, to Q49673|B1308_C1_121|ML0734 putative membrane
protein from Mycobacterium leprae (228 aa), FASTA scores:
opt: 1266,E(): 6.1e-78, (84.2% identity in 228 aa
overlap). Also similar to various proteins (principally
unknowns) e.g. Q9KZ84|SCE25.02 putative integral membrane
protein from Streptomyces coelicolor (190 aa), FASTA
scores: opt: 197,E(): 3.6e-06, (32.0% identity in 150 aa
overlap); BAB50058|MLL3086 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (136 aa), FASTA
scores: opt: 176, E(): 6.9e-05, (34.7% identity in 147 aa
overlap); O29640|AF0615 hypothetical protein from
Archaeoglobus fulgidus (129 aa),FASTA scores: opt: 120,
E(): 0.38, (23.35% identity in 120 aa overlap);
Q9KJU8|GTCA teichoic acid glycosylation protein from
Listeria innocua (145 aa), FASTA scores: opt: 117, E():
0.67, (23.85% identity in 151 aa overlap); etc. Equivalent
to AAK47718 from Mycobacterium tuberculosis strain CDC1551
(256 aa) but longer 16 aa. Contains PS00044 Bacterial
regulatory proteins, lysR family signature. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3277"
/db_xref="EnsemblGenomes-Tr:CCP46096"
/db_xref="GOA:P96882"
/db_xref="InterPro:IPR007267"
/db_xref="UniProtKB/TrEMBL:P96882"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46096.1"
/translation="MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSS
VHSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEP
KPVTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWF
SSYILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKAL
ESALTAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS"
gene complement(3660651..3661169)
/locus_tag="Rv3278c"
CDS complement(3660651..3661169)
/codon_start=1
/transl_table=11
/locus_tag="Rv3278c"
/product="Probable conserved transmembrane protein"
/note="Rv3278c, (MTCY71.18c), len: 172 aa. Probable
conserved transmembrane protein, equivalent to
Q9CCL2|ML0733 putative membrane protein from Mycobacterium
leprae (172 aa), FASTA scores: opt: 1024, E():
6e-61,(83.15% identity in 172 aa overlap); and
Q49672|B1308_F2_67 hypothetical protein from Mycobacterium
leprae (181 aa),FASTA scores: opt: 1024, E(): 6.3e-61,
(83.15% identity in 172 aa overlap) (this is certainly the
same putative protein but with N-terminus longer). Also
some similarity to other hypothetical proteins (generally
membrane proteins) e.g. O26822|MTH726 hypothetical protein
from Methanobacterium thermoautotrophicum (204 aa), FASTA
scores: opt: 147, E(): 0.0079, (24.6% identity in 187 aa
overlap); Q9X8H4|SCE9.01 hypothetical 47.7 KDA protein
(fragment) from Streptomyces coelicolor (436 aa), FASTA
scores: opt: 151, E(): 0.0079, (28.1% identity in 153 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3278c"
/db_xref="EnsemblGenomes-Tr:CCP46097"
/db_xref="GOA:P96883"
/db_xref="InterPro:IPR005182"
/db_xref="UniProtKB/TrEMBL:P96883"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46097.1"
/translation="MSYPENVLAAGEQVVLHRHPHWNRLIWPVVVLVLLTGLAAFGSG
FVNSTPWQQIAKNVIHAVIWGIWLVIVGWLTLWPFLSWLTTHFVVTNRRVMFRHGVLT
RSGIDIPLARINSVEFRDRIFERIFRTGTLIIESASQDPLEFYNIPRLREVHALLYHE
VFDTLGSDESPS"
gene complement(3661212..3662012)
/gene="birA"
/locus_tag="Rv3279c"
CDS complement(3661212..3662012)
/codon_start=1
/transl_table=11
/gene="birA"
/locus_tag="Rv3279c"
/product="Possible bifunctional protein BirA: biotin
operon repressor + biotin--[acetyl-CoA-carboxylase]
synthetase (biotin--protein ligase)"
/note="Rv3279c, (MTCY71.19c), len: 266 aa. Possible
birA,bifunctional protein: biotin operon repressor and
biotin--[acetyl-CoA-carboxylase] synthetase, equivalent to
Q9CCL3|BIRA|ML0732 biotin APO-protein ligase from
Mycobacterium leprae (274 aa), FASTA scores: opt:
1189,E(): 2.3e-66, (71.2% identity in 271 aa overlap). But
as it lacks a BirA h-t-h domain at N-terminus, may simply
be biotin apo-protein ligase. Also similar to others e.g.
Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312
aa),FASTA scores: opt: 347, E(): 2.7e-14, (32.95% identity
in 270 aa overlap); Q9HWC0|BIRA|PA4280 from Pseudomonas
aeruginosa (312 aa), FASTA scores: opt: 335, E():
1.5e-13,(34.2% identity in 272 aa overlap); Q9A6Z0|CC1936
from Caulobacter crescentus (250 aa), FASTA scores: opt:
332,E(): 1.9e-13, (33.6% identity in 238 aa overlap);
P06709|BIRA_ECOLI (321 aa), FASTA scores: opt: 314, E():
3.1e-12, (34.15% identity in 249 aa overlap); etc. Similar
with other bacterial BIRA and with eukaryotic biotin
APO-protein ligase."
/db_xref="EnsemblGenomes-Gn:Rv3279c"
/db_xref="EnsemblGenomes-Tr:CCP46098"
/db_xref="GOA:I6YFP0"
/db_xref="InterPro:IPR003142"
/db_xref="InterPro:IPR004143"
/db_xref="InterPro:IPR004408"
/db_xref="PDB:4OP0"
/db_xref="PDB:4XTU"
/db_xref="PDB:4XTV"
/db_xref="PDB:4XTW"
/db_xref="PDB:4XTX"
/db_xref="PDB:4XTY"
/db_xref="PDB:4XTZ"
/db_xref="PDB:4XU0"
/db_xref="PDB:4XU1"
/db_xref="PDB:4XU2"
/db_xref="PDB:4XU3"
/db_xref="UniProtKB/TrEMBL:I6YFP0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46098.1"
/translation="MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLL
ARAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLS
LAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVT
QAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLT
IGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR"
gene 3662062..3663708
/gene="accD5"
/locus_tag="Rv3280"
CDS 3662062..3663708
/codon_start=1
/transl_table=11
/gene="accD5"
/locus_tag="Rv3280"
/product="Probable propionyl-CoA carboxylase beta chain 5
AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)"
/note="Rv3280, (MTCY71.20, pccB), len: 548 aa. Probable
accD5, propionyl-CoA carboxylase beta chain 5, equivalent
to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 probable
propionyl-CoA carboxylase beta chain 5 from Mycobacterium
leprae (549 aa), FASTA scores: opt: 3241, E():
4e-192,(88.7% identity in 549 aa overlap). Also similar to
many e.g. O87201|DTSR2 DTSR2 protein involved in glutamate
production from Corynebacterium glutamicum (Brevibacterium
flavum) (537 aa), FASTA scores: opt: 2604, E():
6.9e-153,(74.1% identity in 529 aa overlap) (see Kimura et
al.,1996); P53003|PCCB_SACER from Saccharopolyspora
erythraea (Streptomyces erythraeus) (546 aa), FASTA
scores: opt: 2466, E(): 2.2e-144, (70.2% identity in 530
aa overlap); O88155|DTSR1 DTSR1 protein from
Corynebacterium glutamicum (Brevibacterium flavum) (543
aa), FASTA scores: opt: 2375,E(): 8.8e-139, (67.1%
identity in 529 aa overlap; Q9X4K7|PCCB from Streptomyces
coelicolor (530 aa), FASTA scores: opt: 2360, E():
7.3e-138, (67.9% identity in 533 aa overlap);
O24789|mxpccb from Myxococcus xanthus (524 aa),FASTA
scores: opt: 1868, E(): 1.5e-107, (56.85% identity in 524
aa overlap); etc. Also similar with methylmalonyl-CoA
decarboxylases e.g. O59018|PH1287 from Pyrococcus
horikoshii (522 aa), FASTA scores: opt: 1841, E():
6.7e-106, (54.15% identity in 528 aa overlap). Also
similarity with MTCY427.28 (43.8% identity in 434 aa
overlap). Belongs to the ACCD/PCCB family. AccA3
(Rv3285),AccD5 (Rv3280), AccD4 (Rv3799), and AccE5
(Rv3281) form a biotin-dependent acyl-CoA carboxylase in
M. tuberculosis H37Rv (See Oh et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv3280"
/db_xref="EnsemblGenomes-Tr:CCP46099"
/db_xref="GOA:P9WQH7"
/db_xref="InterPro:IPR011762"
/db_xref="InterPro:IPR011763"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR034733"
/db_xref="PDB:2A7S"
/db_xref="PDB:2BZR"
/db_xref="UniProtKB/Swiss-Prot:P9WQH7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46099.1"
/translation="MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVG
EDAVEKVHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVTGY
GTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEG
VVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITG
PDVIKTVTGEEVTMEELGGAHTHMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTD
APRYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYA
QNIVVGFGRIDGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVP
GFLPGTDQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNL
AWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDTLVNPYVAAER
GYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL"
gene 3663689..3664222
/gene="accE5"
/locus_tag="Rv3281"
CDS 3663689..3664222
/codon_start=1
/transl_table=11
/gene="accE5"
/locus_tag="Rv3281"
/product="Probable bifunctional protein
acetyl-/propionyl-coenzyme A carboxylase (epsilon chain)
AccE5"
/note="Rv3281, (MTCY71.21), len: 177 aa. Probable
accE5,bifunctional acetyl-/propionyl-coenzyme A
carboxylase,epsilon chain, equivalent (but longer 14 aa
and with a gap between aa 82-102) to AAK47723|MT3380 from
Mycobacterium tuberculosis strain CDC1551 (142 aa), FASTA
scores: opt: 830, E(): 3.1e-40, (86.5% identity in 163 aa
overlap). C-terminus highly similar to
Q49671|B1308_C3_211|ML0730 from Mycobacterium leprae (84
aa), FASTA scores: opt: 393,E(): 7.6e-16, (68.95% identity
in 87 aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004). AccA3
(Rv3285), AccD5 (Rv3280),AccD4 (Rv3799), and AccE5
(Rv3281) form a biotin-dependent acyl-CoA carboxylase in
M. tuberculosis H37Rv (See Oh et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv3281"
/db_xref="EnsemblGenomes-Tr:CCP46100"
/db_xref="GOA:P96886"
/db_xref="InterPro:IPR032716"
/db_xref="UniProtKB/TrEMBL:P96886"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46100.1"
/translation="MGTCPCESSERNEPVSRVSGTNEVSDGNETNNPAEVSDGNETNN
PAEVSDGNETNNPAPVSRVSGTNEVSDGNETNNPAPVSRVSGTNEVSDGNETNNPAPV
TEKPLHPHEPHIEILRGQPTDQELAALIAVLGSISGSTPPAQPEPTRWGLPVDQLRYP
VFSWQRITLQEMTHMRR"
gene 3664219..3664887
/locus_tag="Rv3282"
CDS 3664219..3664887
/codon_start=1
/transl_table=11
/locus_tag="Rv3282"
/product="Conserved hypothetical protein"
/note="Rv3282, (MTCY71.22), len: 222 aa. Conserved
hypothetical protein, equivalent to Q49670|ML0729 1308R
(hypothetical protein ML0729) from Mycobacterium leprae
(213 aa), FASTA scores: opt: 945, E(): 5.5e-54, (68.55%
identity in 213 aa overlap). Also similar to
Q9EWV6|2SCK31.18 conserved hypothetical protein from
Streptomyces coelicolor (206 aa), FASTA scores: opt:
459,E(): 1.3e-22, (47.35% identity in 209 aa overlap);
P74331|MAF or SLL0905 MAF protein from Synechocystis sp.
strain PCC 6803 (195 aa), FASTA scores: opt: 401, E():
6.9e-19, (43.0% identity in 207 aa overlap); and shows
weak similarity with various proteins e.g. Q9BUL6
acetylserotonin O-methyltransferase-like from Homo sapiens
(Human) (621 aa), FASTA scores: opt: 282, E():
8.9e-11,(31.6% identity in 193 aa overlap); O95671|ASMTL
ASMTL protein from Homo sapiens (Human) (629 aa), FASTA
scores: opt: 282, E(): 9e-11, (31.6% identity in 193 aa
overlap); BAB51136|MLR4491 MAF protein from Rhizobium loti
(Mesorhizobium loti) (199 aa), FASTA scores: opt: 269,
E(): 2.3e-10, (29.3% identity in 198 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3282"
/db_xref="EnsemblGenomes-Tr:CCP46101"
/db_xref="GOA:P9WK27"
/db_xref="InterPro:IPR003697"
/db_xref="InterPro:IPR029001"
/db_xref="UniProtKB/Swiss-Prot:P9WK27"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46101.1"
/translation="MTRLVLGSASPGRLKVLRDAGIEPLVIASHVDEDVVIAALGPDA
VPSDVVCVLAAAKAAQVATTLTGTQRIVAADCVVVACDSMLYIEGRLLGKPASIDEAR
EQWRSMAGRAGQLYTGHGVIRLQDNKTVYRAAETAITTVYFGTPSASDLEAYLASGES
LRVAGGFTLDGLGGWFIDGVQGNPSNVIGLSLPLLRSLVQRCGLSVAALWAGNAGGPA
HKQQ"
gene 3664928..3665821
/gene="sseA"
/locus_tag="Rv3283"
CDS 3664928..3665821
/codon_start=1
/transl_table=11
/gene="sseA"
/locus_tag="Rv3283"
/product="Probable thiosulfate sulfurtransferase SseA
(rhodanese) (thiosulfate cyanide transsulfurase)
(thiosulfate thiotransferase)"
/note="Rv3283, (MTCY71.23), len: 297 aa. Probable
sseA,thiosulfate sulfurtransferase, equivalent
P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 putative
thiosulfate sulfurtransferase SSEA from Mycobacterium
leprae (296 aa), FASTA scores: opt: 1742, E():
5.5e-108,(83.45% identity in 296 aa overlap). Also highly
similar to others e.g. Q9RXT9|DR0217 from Deinococcus
radiodurans (286 aa), FASTA scores: opt: 1057, E():
1.2e-62, (53.86% identity in 273 aa overlap);
P16385|THTR_SACER|CYSA from Saccharopolyspora erythraea
(Streptomyces erythraeus) (281 aa), FASTA scores: opt:
1006, E(): 2.7e-59, (51.25% identity in 277 aa overlap);
P71121|THTR_CORGL from Corynebacterium glutamicum
(Brevibacterium flavum) (225 aa), FASTA scores: opt: 897,
E(): 3.6e-52, (59.05% identity in 215 aa overlap); etc.
Also highly similar to
O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c|M
T0837|MTV043.07c|THTR_MYCTU putative thiosulfate
sulfurtransferase from Mycobacterium tuberculosis (277
aa), FASTA scores: opt: 955, E(): 6.3e-56, (50.2% identity
in 271 aa overlap); and
Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 putative thiosulfate
sulfurtransferase from Mycobacterium leprae (277 aa),
FASTA scores: opt: 931, E(): 2.5e-54, (48.9% identity in
276 aa overlap). Shows some similarity to MTCY339.19c
(30.3% identity in 254 aa overlap). Contains PS00683
Rhodanese C-terminal signature. Belongs to the rhodanese
family. Thought to be differentially expressed within host
cells (see Triccas et al., 1999)."
/db_xref="EnsemblGenomes-Gn:Rv3283"
/db_xref="EnsemblGenomes-Tr:CCP46102"
/db_xref="GOA:P9WHF7"
/db_xref="InterPro:IPR001307"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR036873"
/db_xref="PDB:3HZU"
/db_xref="UniProtKB/Swiss-Prot:P9WHF7"
/inference="protein motif:PROSITE:PS00683"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46102.1"
/translation="MPLPADPSPTLSAYAHPERLVTADWLSAHMGAPGLAIVESDEDV
LLYDVGHIPGAVKIDWHTDLNDPRVRDYINGEQFAELMDRKGIARDDTVVIYGDKSNW
WAAYALWVFTLFGHADVRLLNGGRDLWLAERRETTLDVPTKTCTGYPVVQRNDAPIRA
FRDDVLAILGAQPLIDVRSPEEYTGKRTHMPDYPEEGALRAGHIPTAVHIPWGKAADE
SGRFRSREELERLYDFINPDDQTVVYCRIGERSSHTWFVLTHLLGKADVRNYDGSWTE
WGNAVRVPIVAGEEPGVVPVV"
gene 3665818..3666249
/locus_tag="Rv3284"
CDS 3665818..3666249
/codon_start=1
/transl_table=11
/locus_tag="Rv3284"
/product="Conserved hypothetical protein"
/note="Rv3284, (MTCY71.24, unknown), len: 143 aa.
Conserved hypothetical protein, with similarity to other
bacterial hypothetical proteins e.g. Q9RXU0|DR0216 from
Deinococcus radiodurans (147 aa), FASTA scores: opt: 425,
E(): 9.1e-21,(46.55% identity in 146 aa overlap);
BAB37094|ECS3671 from Escherichia coli strain O157:H7 (147
aa), FASTA scores: opt: 187, E(): 2.2e-05, (29.5% identity
in 139 aa overlap); AAG57925|YGDK from Escherichia coli
strain O157:H7 EDL933 (147 aa), FASTA scores: opt: 187,
E(): 2.2e-05, (32.05% identity in 139 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3284"
/db_xref="EnsemblGenomes-Tr:CCP46103"
/db_xref="InterPro:IPR003808"
/db_xref="UniProtKB/Swiss-Prot:P9WGC3"
/protein_id="CCP46103.1"
/translation="MTAPASLPAPLAEVVSDFAEVQGQDKLRLLLEFANELPALPSHL
AESAMEPVPECQSPLFLHVDASDPNRVRLHFSAPAEAPTTRGFASILAAGLDEQPAAD
ILAVPEDFYTELGLAALISPLRLRGMSAMLARIKRRLREAD"
gene 3666357..3668159
/gene="accA3"
/locus_tag="Rv3285"
CDS 3666357..3668159
/codon_start=1
/transl_table=11
/gene="accA3"
/locus_tag="Rv3285"
/product="Probable bifunctional protein
acetyl-/propionyl-coenzyme A carboxylase (alpha chain)
AccA3: biotin carboxylase + biotin carboxyl carrier
protein (BCCP)"
/note="Rv3285, (MTCY71.25), len: 600 aa. Probable
accA3,bifunctional protein acetyl-/propionyl-coenzyme A
carboxylase, alpha chain (see citations below) equivalent
to P46392|BCCA_MYCLE|BCCA|ML0726|B1308_C1_129
acetyl-/propionyl-coenzyme A carboxylase alpha chain from
Mycobacterium leprae (598 aa), FASTA scores: opt:
3510,E(): 1.1e-196, (89.3% identity in 601 aa overlap).
Also highly similar to other proteins e.g. P71122|ACCBC
acyl coenzyme A carboxylase from Corynebacterium
glutamicum (Brevibacterium flavum) (591 aa), FASTA scores:
opt: 2776,E(): 5.6e-154, (71.95% identity in 592 aa
overlap); Q54119|BCPA2 biotin carboxylase and biotin
carboxyl carrier protein from Saccharopolyspora erythraea
(Streptomyces erythraeus) (591 aa), FASTA scores: opt:
2723, E(): 6.7e-151, (70.5% identity in 590 aa overlap);
Q54105|BCPA biotin carboxylase and biotin carboxyl carrier
protein from Saccharopolyspora erythraea (Streptomyces
erythraeus) (597 aa), FASTA scores: opt: 2721, E():
8.9e-151, (70.05% identity in 594 aa overlap);
Q9EWV4|2SCK31.20 putative acyl-CoA carboxylase complex a
subunit from Streptomyces coelicolor (590 aa), FASTA
scores: opt: 2626, E(): 2.9e-145, (68.25% identity in 595
aa overlap); etc. Contains PS00867 Carbamoyl-phosphate
synthase subdomain signature 2, PS00188 Biotin-requiring
enzymes attachment site. Similar to other biotin-dependent
enzymes and carbamoyl-phosphate synthetases. AccA3
(Rv3285), AccD5 (Rv3280), AccD4 (Rv3799), and AccE5
(Rv3281) form a biotin-dependent acyl-CoA carboxylase in
M. tuberculosis H37Rv (See Oh et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv3285"
/db_xref="EnsemblGenomes-Tr:CCP46104"
/db_xref="GOA:P96890"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR001882"
/db_xref="InterPro:IPR005479"
/db_xref="InterPro:IPR005481"
/db_xref="InterPro:IPR005482"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR011764"
/db_xref="InterPro:IPR016185"
/db_xref="PDB:5MLK"
/db_xref="UniProtKB/TrEMBL:P96890"
/inference="protein motif:PROSITE:PS00867"
/inference="protein motif:PROSITE:PS00188"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46104.1"
/translation="MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAE
PDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFA
QAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEE
YGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRH
VEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEA
HYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDIT
EDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFD
SMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVH
TRWIETEWNNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDP
VGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMK
MENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK"
gene complement(3668169..3668954)
/gene="sigF"
/locus_tag="Rv3286c"
CDS complement(3668169..3668954)
/codon_start=1
/transl_table=11
/gene="sigF"
/locus_tag="Rv3286c"
/product="Alternative RNA polymerase sigma factor SigF"
/note="Rv3286c, (MTCY71.26), len: 261 aa. SigF, stress
response/stationary phase RNA polymerase sigma factor (see
citations below), similar to several Streptomyces RNA
polymerase sigma factors e.g. Q9RPC8|sigh from
Streptomyces coelicolor A3(2) (354 aa), FASTA scores: opt:
869, E(): 1.1e-45, (51.15% identity in 258 aa overlap);
Q9RIT0|SIG1 from Streptomyces coelicolor (361 aa), FASTA
scores: opt: 869, E(): 1.1e-45, (51.15% identity in 258 aa
overlap); Q9ADM4|2SC10A7.38c from Streptomyces coelicolor
(318 aa),FASTA scores: opt: 776, E(): 4.6e-40, (48.75%
identity in 240 aa overlap);
P37971|RPOF_STRCO|SIGF|RPOX|2SCD60.01c from Streptomyces
coelicolor (287 aa), FASTA scores: opt: 717, E(): 1.6e-36,
(44.5% identity in 245 aa overlap);
P37970|RPOF_STRAU|SIGF|RPOX from Streptomyces aureofaciens
(297 aa); etc. Contains possible helix-turn-helix motif at
aa 229-250 (+7.38 SD). Similar to the sigma-70 factor
family. Seems expressed in stationary phase and under
stress conditions in vitro (see citations below)."
/db_xref="EnsemblGenomes-Gn:Rv3286c"
/db_xref="EnsemblGenomes-Tr:CCP46105"
/db_xref="GOA:P9WGI3"
/db_xref="InterPro:IPR000943"
/db_xref="InterPro:IPR007624"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR007630"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR014322"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WGI3"
/protein_id="CCP46105.1"
/translation="MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIV
QRCLPLADHIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGE
VRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELGMDRAEVIE
GLLAGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLLEALPERER
TVLVLRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE"
gene complement(3668951..3669388)
/gene="rsbW"
/gene_synonym="usfX"
/locus_tag="Rv3287c"
CDS complement(3668951..3669388)
/codon_start=1
/transl_table=11
/gene="rsbW"
/gene_synonym="usfX"
/locus_tag="Rv3287c"
/product="Anti-sigma factor RsbW (sigma negative
effector)"
/note="Rv3287c, (MTCY71.27c), len: 145 aa. RsbW (alternate
gene name: usfX), anti-sigma factor (see citations
below),similar to Q49667|B1308_F3_89 from Mycobacterium
leprae (75 aa), FASTA scores: opt: 308, E(): 2.5e-15,
(72.2% identity in 72 aa overlap); Q9R3X8|PRS1|USHX|PRS
PRS1 protein (anti-sigma factor) from Streptomyces
coelicolor (137 aa),FASTA scores: opt: 184, E(): 3.7e-06,
(36.8% identity in 106 aa overlap); O50231 putative
sigma-B regulator from Bacillus licheniformis (160 aa),
FASTA scores: opt: 122,E(): 0.13, (23.9% identity in 92 aa
overlap); and P17904|RSBW_BACSU anti-sigma B factor
(sigma-B negative effector RSBW) from Bacillus subtilis
(160 aa), FASTA scores: opt: 108, E(): 1.3, (21.25%
identity in 127 aa overlap). Equivalent to AAK47729 from
Mycobacterium tuberculosis strain CDC1551 (145 aa) but
longer 99 aa. Induction by heat shock, salt stress,
oxidative stress,glucose limitation and oxygen limitation.
N-terminus shortened since first submission (previously
242 aa). Binds ATP, GTP."
/db_xref="EnsemblGenomes-Gn:Rv3287c"
/db_xref="EnsemblGenomes-Tr:CCP46106"
/db_xref="GOA:P9WGX7"
/db_xref="UniProtKB/Swiss-Prot:P9WGX7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46106.1"
/translation="MADSDLPTKGRQRGVRAVELNVAARLENLALLRTLVGAIGTFED
LDFDAVADLRLAVDEVCTRLIRSALPDATLRLVVDPRKDEVVVEASAACDTHDVVAPG
SFSWHVLTALADDVQTFHDGRQPDVAGSVFGITLTARRAASSR"
gene complement(3669586..3669999)
/gene="usfY"
/locus_tag="Rv3288c"
CDS complement(3669586..3669999)
/codon_start=1
/transl_table=11
/gene="usfY"
/locus_tag="Rv3288c"
/product="Putative protein UsfY"
/note="Rv3288c, (MTCY71.28c), len: 137 aa. UsfY, putative
protein (see citation below). Has no significant
homologues. May not be contranscribed with the usfX and
sigF proteins."
/db_xref="EnsemblGenomes-Gn:Rv3288c"
/db_xref="EnsemblGenomes-Tr:CCP46107"
/db_xref="GOA:L7N685"
/db_xref="UniProtKB/TrEMBL:L7N685"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46107.1"
/translation="MGQIPPQPVRRVLPLMVVPGNGQKWRNRTETEEAMGDTYRDPVD
HLRTTRPLAGESLIDVVHWPGYLLIVAGVVGGVGALAAFGTGHHAEGMTFGVVAIVVT
VVGLAWLAFEHRRIRKIADRWYTEHPEVRRQRLAG"
gene complement(3670034..3670411)
/locus_tag="Rv3289c"
CDS complement(3670034..3670411)
/codon_start=1
/transl_table=11
/locus_tag="Rv3289c"
/product="Possible transmembrane protein"
/note="Rv3289c, (MTCY71.29c), len: 125 aa. Possible
transmembrane protein, showing slight similarity to other
membrane proteins or glycoproteins."
/db_xref="EnsemblGenomes-Gn:Rv3289c"
/db_xref="EnsemblGenomes-Tr:CCP46108"
/db_xref="GOA:P96894"
/db_xref="UniProtKB/TrEMBL:P96894"
/protein_id="CCP46108.1"
/translation="MHEVGGPSRGDRLGRDDSEVHSAIRFAVVAAVVGVGFLIMGALL
VSTCSGVDTAACGPPQRILLALGGPLILCAAGLWAFLRTYRVWRAEGTWWGWHGAGWF
LLTLMVLTLCIGVPPIAGPVMAP"
gene complement(3670445..3671794)
/gene="lat"
/locus_tag="Rv3290c"
CDS complement(3670445..3671794)
/codon_start=1
/transl_table=11
/gene="lat"
/locus_tag="Rv3290c"
/product="Probable L-lysine-epsilon aminotransferase Lat
(L-lysine aminotransferase) (lysine 6-aminotransferase)"
/note="Rv3290c, (MTCY71.30), len: 449 aa. Probable
lat,lysine-epsilon aminotransferase, similar to
Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa),
FASTA scores: opt: 1702, E(): 1.1e-99, (60.35% identity in
439 aa overlap); and Q01767|Q53823|LAT_STRCL from
Streptomyces clavuligerus (457 aa), FASTA scores: opt:
1676, E(): 4.9e-98, (60.15% identity in 434 aa overlap).
Also some similarity to 4-aminobutyrate aminotransferase
proteins (gamma-amino-N-butyrate transaminases). Belongs
to class-III of pyridoxal-phosphate-dependent
aminotransferases. Cofactor: pyridoxal phosphate."
/db_xref="EnsemblGenomes-Gn:Rv3290c"
/db_xref="EnsemblGenomes-Tr:CCP46109"
/db_xref="GOA:P9WQ77"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR017657"
/db_xref="PDB:2CIN"
/db_xref="PDB:2CJD"
/db_xref="PDB:2CJG"
/db_xref="PDB:2CJH"
/db_xref="PDB:2JJE"
/db_xref="PDB:2JJF"
/db_xref="PDB:2JJG"
/db_xref="PDB:2JJH"
/db_xref="UniProtKB/Swiss-Prot:P9WQ77"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46109.1"
/translation="MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGG
SYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVA
MARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQV
LHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEAL
RQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTG
CGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGN
LTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFS
LPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT"
gene complement(3671845..3672297)
/gene="lrpA"
/locus_tag="Rv3291c"
CDS complement(3671845..3672297)
/codon_start=1
/transl_table=11
/gene="lrpA"
/locus_tag="Rv3291c"
/product="Probable transcriptional regulatory protein LrpA
(Lrp/AsnC-family)"
/note="Rv3291c, (MTCY71.31c), len: 150 aa. Probable
lrpA,transcriptional regulator Lrp/AsnC-family, similar to
other regulatory proteins e.g. Q9RKY4|SC6D7.14 from
Streptomyces coelicolor (165 aa), FASTA scores: opt: 503,
E(): 9.1e-26,(50.35% identity in 143 aa overlap);
Q9KYP0|SCD69.13 from Streptomyces coelicolor (167 aa),
FASTA scores: opt: 310,E(): 2.7e-13, (37.2% identity in
129 aa overlap); BAB50701|MLL3910 from Rhizobium loti
(Mesorhizobium loti) (152 aa), FASTA scores: opt: 282,
E(): 1.6e-11, (39.55% identity in 129 aa overlap);
O87635|LRP_KLEAE from Klebsiella aerogenes (163 aa), FASTA
scores: opt: 279, E(): 2.5e-11, (38.1% identity in 147 aa
overlap); etc. Contains helix-turn-helix motif at aa 22-43
(+3.94 SD). Could belong to the Lrp/AsnC family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3291c"
/db_xref="EnsemblGenomes-Tr:CCP46110"
/db_xref="GOA:I6YBQ3"
/db_xref="InterPro:IPR000485"
/db_xref="InterPro:IPR011008"
/db_xref="InterPro:IPR019887"
/db_xref="InterPro:IPR019888"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/TrEMBL:I6YBQ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46110.1"
/translation="MNEALDDIDRILVRELAADGRATLSELATRAGLSVSAVQSRVRR
LESRGVVQGYSARINPEAVGHLLSAFVAITPLDPSQPDDAPARLEHIEEVESCYSVAG
EESYVLLVRVASARALEDLLQRIRTTANVRTRSTIILNTFYSDRQHIP"
gene 3672328..3673575
/locus_tag="Rv3292"
CDS 3672328..3673575
/codon_start=1
/transl_table=11
/locus_tag="Rv3292"
/product="Conserved hypothetical protein"
/note="Rv3292, (MTCY71.32), len: 415 aa. Conserved
hypothetical protein, similar to P76097|YDCJ_ECOLI|B1423
hypothetical 51.0 KDA protein from Escherichia coli strain
K12 (447 aa), FASTA scores: opt: 747, E(): 5.6e-39,
(38.55% identity in 449 aa overlap); BAB35451|ECS2028
hypothetical 51.0 KDA protein from Escherichia coli strain
O157:H7 (447 aa), FASTA scores: opt: 744, E(): 8.6e-39,
(38.3% identity in 449 aa overlap); AAG56352|Z2297 protein
from Escherichia coli O157:H7 EDL933 (212 aa), FASTA
scores: opt: 454, E(): 4.6e-21, (41.75% identity in 206 aa
overlap); and similar in part with Q49664|B1308_C1_136
from Mycobacterium leprae (71 aa), FASTA scores: opt: 305,
E(): 3.2e-12, (70.0% identity in 70 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3292"
/db_xref="EnsemblGenomes-Tr:CCP46111"
/db_xref="InterPro:IPR009770"
/db_xref="UniProtKB/Swiss-Prot:P9WL01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46111.1"
/translation="MSRSKRLQTGQLRARFAAGLSAMYAAEVPAYGTLVEVCAQVNSD
YLTRHRRAERLGSLQRVTAERHGAIRVGNPAELAAVADLFAAFGMLPVGYYDLRTAES
PIPVVSTAFRPIDANELAHNPFRVFTSMLAIEDRRYFDADLRTRVQTFLARRQLFDPA
LLAQARAIAADGGCDADDAPAFVAAAVAAFALSREPVEKSWYDELSRVSAVAADIAGV
GSTHINHLTPRVLDIDDLYRRMTERGITMIDTIQGPPRTDGPDVLLRQTSFRALAEPR
MFRDEDGTVTPGILRVRFGEVEARGVALTPRGRERYEAAMAAADPAAVWATHFPSTDA
EMAAQGLAYYRGGDPSAPIVYEDFLPASAAGIFRSNLDRDSQTGDGPDDAGYNVDWLA
GAIGRHIHDPYALYDALAQEERR"
gene 3673602..3675086
/gene="pcd"
/gene_synonym="aldB"
/locus_tag="Rv3293"
CDS 3673602..3675086
/codon_start=1
/transl_table=11
/gene="pcd"
/gene_synonym="aldB"
/locus_tag="Rv3293"
/product="Probable piperideine-6-carboxilic acid
dehydrogenase Pcd (piperideine-6-carboxylate
dehydrogenase)"
/note="Rv3293, (MTCY71.33), len: 494 aa. Probable
pcd,piperideine-6-carboxylic acid dehydrogenase, highly
similar to others e.g. O85725|PCD semialdehyde
dehydrogenase from Streptomyces clavuligerus (512 aa),
FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity
in 496 aa overlap) (see Alexander & Jensen 1998);
Q9I4U7|PA1027 probable aldehyde dehydrogenase from
Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984,
E(): 1.4e-107, (64.5% identity in 493 aa overlap);
BAB49892|MLL2867 aldehyde dehydrogenase from Rhizobium
loti (Mesorhizobium loti) (504 aa), FASTA scores: opt:
1964, E(): 2e-106, (62.8% identity in 476 aa overlap);
Q9A8Y1|CC1216 aldehyde dehydrogenase from Caulobacter
crescentus (507 aa), FASTA scores: opt: 1909, E():
3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD
piperideine-6-carboxilic acid dehydrogenase from
Streptomyces clavuligerus (496 aa), FASTA scores: opt:
1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap);
and Q9F1U8|PCD piperideine-6-carboxylate dehydrogenase
from 'Flavobacterium' lutescens (510 aa), FASTA scores:
opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa
overlap) (see Fujii et al., 2000); etc. Contains PS00687
Aldehyde dehydrogenases glutamic acid active site. Note
that ORF Rv3290c seems to encoded the putative lat enzyme.
Note that previously known as aldB."
/db_xref="EnsemblGenomes-Gn:Rv3293"
/db_xref="EnsemblGenomes-Tr:CCP46112"
/db_xref="GOA:L7N650"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/TrEMBL:L7N650"
/inference="protein motif:PROSITE:PS00687"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46112.1"
/translation="MLEACQAIGVTAALGEPGEHSLPASTPITGDVLFSIAPTTPEQA
DHAIAAAAATFTAWRSTPAPVRGALVARLGELLTAHQQDLATLVTVEVGKITAEARGE
VQEMIDVCQFSVGLSRQLYGRTIASERAGHRLLETWHPLGVVGVITAFNFPVAVWAWN
TAVALVCGDTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLV
DDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLELAVRGIVF
AAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDPSAPDTLVGPLIHEAAY
RDMVAALERARTDGGEVIGGDRREVGSPGAYYVAPAVVRMPSQTAIVATETFAPILYV
LTYDDLDEAIALNNAVPQGLSSSIFTTDLREAEHFLDQSDCGIANVNIGTSGAEIGGA
FGGEKQTGGGRESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG"
gene complement(3675186..3675995)
/locus_tag="Rv3294c"
CDS complement(3675186..3675995)
/codon_start=1
/transl_table=11
/locus_tag="Rv3294c"
/product="Conserved hypothetical protein"
/note="Rv3294c, len: 269 aa. Conserved hypothetical
protein, similar to several conserved hypothetical
proteins from Mycobacterium tuberculosis: O07781|Rv0597c
(411 aa),FASTA scores: opt: 682, E(): 3.6e-37, (44.85%
identity in 243 aa overlap); O53329|Rv3179 (454 aa), FASTA
scores: opt: 561, E(): 3.3e-29, (42.20% identity in 218 aa
overlap); Q10849|YK08_MYCTU|Rv2008c (441 aa), FASTA
scores: opt: 194,E(): 3.9e-05, (30.10% identity in 239 aa
overlap). Also some similarity with proteins from other
organisms. Replace previous Rv3294 on opposite strand."
/db_xref="EnsemblGenomes-Gn:Rv3294c"
/db_xref="EnsemblGenomes-Tr:CCP46113"
/db_xref="InterPro:IPR025420"
/db_xref="UniProtKB/TrEMBL:L7N658"
/protein_id="CCP46113.1"
/translation="MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAK
ARNVDRVVKRDAADVSNLQRIADLPRLIRLLAARSASELNLSSLATDAEIPVRTLPPY
LDLLETLYLIDRIPAWSTNLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAA
GAIIETFVIAELRRQLGWSQQAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATL
RGRDTRSISRLRDKVGARFAGGVILHTGPQAQPFGDRLAAVPIDILWSPSG"
gene 3676066..3676731
/locus_tag="Rv3295"
CDS 3676066..3676731
/codon_start=1
/transl_table=11
/locus_tag="Rv3295"
/product="Probable transcriptional regulatory protein
(probably TetR-family)"
/note="Rv3295, (MTCY71.35), len: 221 aa. Probable
transcriptional regulator TetR-family, equivalent to
Q9CCL4|ML0717 putative TetR-family transcriptional
regulator from Mycobacterium leprae (223 aa), FASTA
scores: opt: 1260, E(): 7.2e-75, (85.45% identity in 220
aa overlap). Also highly similar to other streptomyces
regulators e.g. Q9RD77|SCF43.11 from Streptomyces
coelicolor (205 aa), FASTA scores: opt: 442, E():
9.8e-22,(38.6% identity in 202 aa overlap);
Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa),
FASTA scores: opt: 215,E(): 5.9e-07, (31.85% identity in
135 aa overlap); Q9L0U5|SCD35.06 from Streptomyces
coelicolor (240 aa),FASTA scores: opt: 214, E(): 7.4e-07,
(28.2% identity in 156 aa overlap); etc. Similar to the
TetR/AcrR family of transcriptional regulators. Contains
potential helix-turn-helix motif at aa 33-54 (+4.42 SD)."
/db_xref="EnsemblGenomes-Gn:Rv3295"
/db_xref="EnsemblGenomes-Tr:CCP46114"
/db_xref="GOA:P96900"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="UniProtKB/TrEMBL:P96900"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46114.1"
/translation="MATARRRLSPQDRRAELLALGAEVFGKRPYDEVRIDEIAERAGV
SRALMYHYFPDKRAFFAAVVKDEADRLYAATNKAPAPGMTMFEEIRTGVLAYMAYHQQ
NPEAAWAAYVGLGRSDPVLLGIDDEAKNRQMEHIMSRIAEVVSGIDRDNTLDPEVERD
LRVIIHGWLAFTFELCRQRIMDPSTDAERLADACAHALLDAISRLPQIPAELADAMAT
ARM"
gene 3676775..3681316
/gene="lhr"
/locus_tag="Rv3296"
CDS 3676775..3681316
/codon_start=1
/transl_table=11
/gene="lhr"
/locus_tag="Rv3296"
/product="Probable ATP-dependent helicase Lhr (large
helicase-related protein)"
/note="Rv3296, (MTCY71.36), len: 1513 aa. Probable
lhr,ATP-dependent helicase, similar to others e.g.
P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain
K12 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159,
(47.55% identity in 1569 aa overlap); AAG56642|LHR from
Escherichia coli stain O157:H7 EDL933 (1538 aa), FASTA
scores: opt: 2930, E(): 1.5e-159, (47.6% identity in 1561
aa overlap); O86821|SC7C7.16c from Streptomyces coelicolor
(1690 aa),FASTA scores: opt: 2919, E(): 7e-159, (53.55%
identity in 1703 aa overlap); Q9HYW9|PA3272 from
Pseudomonas aeruginosa (1448 aa), FASTA scores: opt: 907,
E(): 6.2e-44, (35.85% identity in 1512 aa overlap); etc.
Similar to dead/DEAH box helicase family and to helicase
C-terminal domain. Contains PS00017 ATP/GTP-binding site
motif A and possible helix-turn-helix motif."
/db_xref="EnsemblGenomes-Gn:Rv3296"
/db_xref="EnsemblGenomes-Tr:CCP46115"
/db_xref="GOA:P96901"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR013701"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P96901"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46115.1"
/translation="MRFAQPSALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNT
LVIAPTGSGKTLAAFLWALDSLAGSEPMSERPAATRVLYVSPLKALAVDVERNLRTPL
AGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQPPDVLITTPESLFLMLTSAAR
QTLTGVQTVIIDEIHAIAATKRGAHLALSLERLDDLSSRRRAQRIGLSATVRPPEELA
RFLSGQSPTTIVAPPAAKTVELSVQVPVPDMANLTDNTIWPDVEARLVDLIESHNSTI
VFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAPAHIMGSGQTFGAPPVLA
RAHHGSISKEQRAVVEEDLKRGQLKAVVATSSLELGIDMGAVDLVIQVQAPPSVASGL
QRIGRAGHQVGEISRGVLFPKHRTDLLGCAVSVQRMLAGEIETMRVPANPLDILAQHT
VAAAALEPLDADAWFDTVRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYD
RDTGTLTARPGAQRLAVTSGGAIPDRGLFAVYLATERPSRVGELDEEMVYESRPGDVI
SLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAALGALTGELAALD
RTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDSTLLVERFRDELGDWRVILH
SPYGLRVHGPLALAVGRRLRDRYGIDEKPTASDNGIVVRLPDTVSAGEDSPPGAELFV
FDADEIDPIVTTEVAGSALFASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEV
ARKYPDFPIVLETVRECLQDVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLF
GYVGAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQLQHLA
ADRVARDAEGVADLLRLLGPLTEDEIAARAGAPEVSGWLDGLRAAKRALVVSFAGRSW
WVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPLGELLGRYARTHTPFTTAAAAARFG
LGLRVTADVLGRLASDGRLVRGEFVAAAKGSAGGEQWCDAEVLRILRRRSLAALRAQA
EPVSTAAYGRFLPAWQHVSAGNSGIDGLAAVIDQLAGVRIPASAIEPLVLAPRIRDYS
PAMLDELLASGDVTWSGAGSISGSDGWIALHPADSAPMTLAEPAEIDFTDAHRAILAS
LGTGGAYFFRQLTHDGLTEAELKAALWELIWAGRVTGDTFAPVRAVLGGAGTRKRAAP
AHGGHRPPRLSRYRLTHAQARNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGV
LTKDAVAAEGVAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDRLRSYL
DGVDPEQPDYHAVVLAAADPANPYGAALPWPASSADGTARPGRKAGALVVLVDGELAW
FLERGGRSLLTFTDDPEANHAAAIGLADLVTAGRVASILVERADGMPVLQPGGRASAA
LTALLAAGFVRTPRGLRRR"
gene 3681320..3682087
/gene="nei"
/locus_tag="Rv3297"
CDS 3681320..3682087
/codon_start=1
/transl_table=11
/gene="nei"
/locus_tag="Rv3297"
/product="Probable endonuclease VIII Nei"
/note="Rv3297, (MTCY71.37, MT3396), len: 255 aa. Probable
nei, endonuclease VIII (see citation below), similar to
others e.g. O86820|END8_STRCO|NEI|SC7C7.15c from
Streptomyces coelicolor (276 aa), FASTA scores: opt:
770,E(): 1.2e-42, (50.35% identity in 268 aa overlap);
P50465|END8_ECOLI|NEI|B0714 from Escherichia coli strain
K12 (262 aa), FASTA scores: opt: 310, E(): 6.3e-13, (28.1%
identity in 267 aa overlap); AAG55037|NEI from Escherichia
coli strain O157:H7 EDL933 (263 aa), FASTA scores: opt:
301, E(): 2.4e-12, (27.7% identity in 267 aa overlap);
etc. Belongs to the FPG family."
/db_xref="EnsemblGenomes-Gn:Rv3297"
/db_xref="EnsemblGenomes-Tr:CCP46116"
/db_xref="GOA:P9WNC1"
/db_xref="InterPro:IPR000214"
/db_xref="InterPro:IPR010979"
/db_xref="InterPro:IPR012319"
/db_xref="InterPro:IPR015886"
/db_xref="InterPro:IPR015887"
/db_xref="InterPro:IPR035937"
/db_xref="UniProtKB/Swiss-Prot:P9WNC1"
/protein_id="CCP46116.1"
/translation="MPEGDTVWHTAATLRRHLAGRTLTRCDIRVPRFAAVDLTGEVVD
EVISRGKHLFIRTGTASIHSHLQMDGSWRVGNRPVRVDHRARIILEANQQEQAIRVVG
VDLGLLEVIDRHNDGAVVAHLGPDLLADDWDPQRAAANLIVAPDRPIAEALLDQRVLA
GIGNVYCNELCFVSGVLPTAPVSAVADPRRLVTRARDMLWVNRFRWNRCTTGDTRAGR
RLWVYGRAGQGCRRCGTLIAYDTTDERVRYWCPACQR"
gene complement(3682110..3683024)
/gene="lpqC"
/locus_tag="Rv3298c"
CDS complement(3682110..3683024)
/codon_start=1
/transl_table=11
/gene="lpqC"
/locus_tag="Rv3298c"
/product="Possible esterase lipoprotein LpqC"
/note="Rv3298c, (MTCY71.38c), len: 304 aa. Possible
lpqC,esterase lipoprotein, equivalent to
Q9CCL5|LPQC|ML0715 putative secreted hydrolase from
Mycobacterium leprae (304 aa), FASTA scores: opt: 1543,
E(): 1.3e-87, (71.6% identity in 303 aa overlap); and
Q49658|B1308_F2_43 tubulin family protein from
Mycobacterium leprae (302 aa), FASTA scores: opt: 1541,
E(): 1.7e-87, (72.0% identity in 300 aa overlap). Also
similar to Q9I5Z3|PA0543 hypothetical protein from
Pseudomonas aeruginosa (322 aa), FASTA scores: opt: 439,
E(): 8.9e-20, (32.3% identity in 319 aa overlap);
Q9F2K9|SCH63.19c putative secreted protein from
Streptomyces coelicolor (348 aa), FASTA scores: opt:
394,E(): 5.5e-17, (30.25% identity in 334 aa overlap);
etc. And similar to O86367|LPQP|Rv0671|MTCI376.03c from
Mycobacterium tuberculosis strain H37Rv (280 aa), FASTA
scores: opt: 519, E(): 9.8e-25, (39.25% identity in 275 aa
overlap). Probably lipoprotein, esterase
membrane-bound,with 18 aa signal sequence as it contains
appropriately positioned (PS00013) Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3298c"
/db_xref="EnsemblGenomes-Tr:CCP46117"
/db_xref="GOA:P96903"
/db_xref="InterPro:IPR010126"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:P96903"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46117.1"
/translation="MPWARMLSLIVLMVCLAGCGGDQLLARHASSVATFQFGGLTRSY
RLHVPPAEPSGLVISLHGGGGTGAGQEALTDFDAVADAADLLVVYPDGYDKSWADGRG
ASPADRRHLDDVGFLVALAAKLVHDFDIAPGHVFATGMSNGGFMSNRLACDRADIFAA
VAPVAGTLGVGVTCNPSRPVSVLEAHGTADPLVPFNGGAVRGRGGLSHSISVASLVDR
WRAVDGCQGDPSAAELPDVGDGTMVHLFDSSSCAAGTEVISYQIDNGGHTWPGGRQYL
PKAVIGATTRAFDGSQVIAQFFATHGRD"
gene complement(3683051..3685963)
/gene="atsB"
/locus_tag="Rv3299c"
CDS complement(3683051..3685963)
/codon_start=1
/transl_table=11
/gene="atsB"
/locus_tag="Rv3299c"
/product="Probable arylsulfatase AtsB (aryl-sulfate
sulphohydrolase) (sulfatase)"
/note="Rv3299c, (MTCI418A.01c, MTCY71.39c), len: 970 aa.
Probable atsB, arylsulfatase, similar to
P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from
Pseudomonas aeruginosa (535 aa), FASTA scores: opt:
645,E(): 5.8e-31, (32.0% identity in 550 aa overlap);
Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa), FASTA
scores: opt: 504, E(): 1.7e-22, (26.3% identity in 566 aa
overlap); and P20713|ATSA|ARS_KLEAE (precursor) from
Klebsiella pneumoniae (464 aa), FASTA scores: opt:
502,E(): 1.8e-22, (26.85% identity in 451 aa overlap).
Also similar to Mycobacterium tuberculosis proteins
O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6% identity in
796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa)
(38.4% identity in 797 aa overlap). Equivalent to AAK47741
from Mycobacterium tuberculosis strain CDC1551 (992 aa)
but shorter 22 aa. Contains PS00523 Sulfatases signature 1
and PS01095 Chitinases family 18 active site signature.
Belongs to the sulfatase family."
/db_xref="EnsemblGenomes-Gn:Rv3299c"
/db_xref="EnsemblGenomes-Tr:CCP46118"
/db_xref="GOA:O65931"
/db_xref="InterPro:IPR000917"
/db_xref="InterPro:IPR009200"
/db_xref="InterPro:IPR017850"
/db_xref="InterPro:IPR024607"
/db_xref="UniProtKB/TrEMBL:O65931"
/inference="protein motif:PROSITE:PS01095"
/inference="protein motif:PROSITE:PS00523"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46118.1"
/translation="MMSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLI
GKDAEGSPVLVDTGNRLGRRGAAWGAGVGLAIGLFSPALLASAALGAATGALAGTFAH
HRIKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALASSPMKSVAELSRSTLRSLG
AALREAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWSIVPGPFPPDDAPNVLIVL
IDDAGFGGPDTFGGAIRTPTLSRLAQNGLIYNRFHVTAVCSPTRAALLTGRNHHRVGF
GSVCEFPGPYPGYSAVRPRSCAALPRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNW
PLGWGFDHFWGFPSGAAGQYDPIISQDNSVIGIPEGSGEDGRPYYFPDDLTDKAIEWL
HTVRAQNATKPWMLYYATGATHAPHHVFKEWADKYRGEFDDGWDVYRQKTFERQKRLG
IIPPDAELTERPDLFPAWDSMSEAQKRLFARQMEVFAGFSENADWNVGRLLDAIEDLG
ESDNTLVFYIWGDNGASMEGTNTGSFNEMTFLNGLDLDAERQLELIEQYGGIAALGDE
FTAPHFASAWAHASNTPLQWGKQMASHLGGTRDPLVVAWPARIRPDGRVRSQFTHCID
IAPTVLAAIGLPEPTHVDGFEQEPMDGTSFVRTFDDAEAEDRHTVQYFENFGSRAIYK
DGWWACARLDKAPWDLSPETMRRFAPGTYDPDQDVWELYYLPDDFSQAKNLAAEHPDK
VAELTQLWWQEAERNRVLPLLGGLAVMFGDLPPLPTTARFSFKGDVQNIQRGMVPRIC
GRSYAIEARLHIPDGGAQGVIVANADFMGGFALWVDEQRHLHHTYSFLGVETYRQVSS
EPLPTGDVTVRMLFDSHQPVAASGGRVTLWADDRLIGEGELPQTVPLAFTSYAGMDIG
RDNGLVVDRGYEDKAPYAFTGTVTEVIFDLKPVHPEAARALHEHASVQAVGQGAAG"
gene complement(3685983..3686900)
/locus_tag="Rv3300c"
CDS complement(3685983..3686900)
/codon_start=1
/transl_table=11
/locus_tag="Rv3300c"
/product="Conserved hypothetical protein"
/note="Rv3300c, (MTCI418A.02c), len: 305 aa. Conserved
hypothetical protein, similar to various proteins (notably
pseudoridine synthase family proteins) e.g.
Q9RJ76|SCI41.08 putative ribosomal pseudouridine synthase
from Streptomyces coelicolor (324 aa), FASTA scores: opt:
876, E(): 4.5e-48,(52.1% identity in 313 aa overlap);
Q9I272|PA2043 hypothetical protein from Pseudomonas
aeruginosa (300 aa),FASTA scores: opt: 676, E(): 1.8e-35,
(42.55% identity in 268 aa overlap); Q9JZW8|NMB0867
YABO/YCEC/SFHB family protein from Neisseria meningitidis
(serogroup B) (307 aa),FASTA scores: opt: 597, E():
1.8e-30, (42.9% identity in 282 aa overlap);
Q9JUY2|NMA1085 hypothetical protein from Neisseria
meningitidis (serogroup A) (307 aa), FASTA scores: opt:
597, E(): 1.8e-30, (42.9% identity in 282 aa overlap);
Q12362|RIB2_YEAST|RIB2|YOL066C DRAP deaminase
(pseudouridine synthase family protein) from Saccharomyces
cerevisiae (Baker's yeast) (591 aa), FASTA scores: opt:
338, E(): 6.9e-14, (32.95% identity in 246 aa overlap);
Q9RTS2|DR1684 putative pseudouridine synthase from
Deinococcus radiodurans (321 aa), FASTA scores: opt:
319,E(): 6.5e-13, (32.75% identity in 235 aa overlap);
etc. Also similar to Mycobacterium tuberculosis
hypothetical protein
Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308 aa) (28.8%
identity in 299 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3300c"
/db_xref="EnsemblGenomes-Tr:CCP46119"
/db_xref="GOA:O07166"
/db_xref="InterPro:IPR006145"
/db_xref="InterPro:IPR006224"
/db_xref="InterPro:IPR020103"
/db_xref="UniProtKB/TrEMBL:O07166"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46119.1"
/translation="MALRPEDRLLSVHDVLGPVRVRLLGGSVLAELTARFGVAARAKV
LAGEVVDDDGAVVDSGTVLPPGSVVHLYRDLPDEVPVPFDVPVLHQDADIVVVDKPHF
LATMPRGRHVAQTALVRLRRELGLPELSPAHRLDRLTAGVLLFTTRREVRGSYQTMFA
RGLVRKTYLARAPVAPGLALPRLVRSRIVKRRGHLQAVCEPGVPNAETLVERIARDGL
YRLTPTTGRTHQLRVHMAALGIPIMGDPLYPNVISVAAHDFSTPLQLLAQRIEFDDPL
TGSHREFASTRTLTGATLPTWSAAADCRP"
gene complement(3686912..3687577)
/gene="phoY1"
/locus_tag="Rv3301c"
CDS complement(3686912..3687577)
/codon_start=1
/transl_table=11
/gene="phoY1"
/locus_tag="Rv3301c"
/product="Probable phosphate-transport system
transcriptional regulatory protein PhoU homolog 1 PhoY1"
/note="Rv3301c, (MTCI418A.03c), len: 221 aa. Probable
phoY1, phosphate-transport system regulatory
protein,highly similar to Q50047|phoY|PHOU1|PHOY1|ML2188
phosphate transport system protein PHOU homolog 1 from
Mycobacterium leprae (222 aa), FASTA scores: opt: 929,
E(): 7.8e-51,(61.45% identity in 218 aa overlap). Also
highly similar to Q9FCE2|2SCD46.42c putative regulatory
protein (fragment) from Streptomyces coelicolor (123 aa),
FASTA scores: opt: 324, E(): 1.8e-13, (43.65% identity in
103 aa overlap); Q9L0R3|SCD8A.01c putative phosphate
transport system regulatory protein (fragment) from
Streptomyces coelicolor (139 aa), FASTA scores: opt: 309,
E(): 1.7e-12, (36.7% identity in 139 aa overlap);
Q52989|PHOU_RHIME phosphate transport system protein from
Rhizobium meliloti (Sinorhizobium meliloti) (237 aa),
FASTA scores: opt: 292,E(): 3.1e-11, (26.3% identity in
213 aa overlap); etc. And highly similar to Mycobacterium
tuberculosis O53833|PHU2_MYCTU|MTV043_13c|PHOU2|PHOY2|Rv08
21c|MT0843 phosphate transport system protein PHOU homolog
2 (213 aa) (63.4% identity in 213 aa overlap). Belongs to
the PHOU family."
/db_xref="EnsemblGenomes-Gn:Rv3301c"
/db_xref="EnsemblGenomes-Tr:CCP46120"
/db_xref="GOA:P9WI97"
/db_xref="InterPro:IPR026022"
/db_xref="InterPro:IPR028366"
/db_xref="InterPro:IPR038078"
/db_xref="UniProtKB/Swiss-Prot:P9WI97"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46120.1"
/translation="MRTVYHQRLTELAGRLGEMCSLAGIAMKRATQALLEADIGAAEQ
VIRDHERIVAMRAQVEKEAFALLALQHPVAGELREIFSAVQIIADTERMGALAVHIAK
ITRREYPNQVLPEEVRNCFADMAKVAIALGDSARQVLVNRDPQEAAQLHDRDDAMDDL
HRHLLSVLIDREWRHGVRVGVETALLGRFFERFADHAVEVGRRVIFMVTGVLPTEDEI
STY"
gene complement(3687685..3689442)
/gene="glpD2"
/locus_tag="Rv3302c"
CDS complement(3687685..3689442)
/codon_start=1
/transl_table=11
/gene="glpD2"
/locus_tag="Rv3302c"
/product="Probable glycerol-3-phosphate dehydrogenase
GlpD2"
/note="Rv3302c, (MTCI418A.04c, MTV016.01c), len: 585 aa.
Probable glpd2, glycerol-3-phosphate
dehydrogenase,equivalent to
P53435|GLPD_MYCLE|ML0713|L308_C1_179 glycerol-3-phosphate
dehydrogenase from Mycobacterium leprae (585 aa), FASTA
scores: opt: 3489, E(): 2.2e-198,(90.75% identity in 584
aa overlap). Also highly similar to many e.g.
Q9L0I3|SCD63.06 from Streptomyces coelicolor (568 aa),
FASTA scores: opt: 2203, E(): 1.6e-122, (59.95% identity
in 564 aa overlap); Q9RVK8|DR1019 from Deinococcus
radiodurans (522 aa), FASTA scores: opt: 949, E():
1.4e-48,(37.0% identity in 538 aa overlap);
BAB53412|MLR7270 from Rhizobium loti (Mesorhizobium loti)
(505 aa), FASTA scores: opt: 861, E(): 2.2e-43, (37.3%
identity in 488 aa overlap); P18158|GLPD_BACSU from B.
subtilis (555 aa), FASTA scores: opt: 768, E(): 7.2e-38,
(32.85% identity in 484 aa overlap); etc. Also similar to
Mycobacterium tuberculosis protein
Q10502|GLPD_MYCTU|MTCY427_31c|Rv2249c glycerol-3-phosphate
dehydrogenase (516 aa), FASTA scores: opt: 843, E():
2.6e-42, (36.5% identity in 515 aa overlap). Contains
PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase
signature 2. Cofactor: FAD (by similarity). Belongs to the
FAD-dependent glycerol-3-phosphate dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv3302c"
/db_xref="EnsemblGenomes-Tr:CCP46121"
/db_xref="GOA:P9WN79"
/db_xref="InterPro:IPR000447"
/db_xref="InterPro:IPR006076"
/db_xref="InterPro:IPR031656"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR038299"
/db_xref="UniProtKB/Swiss-Prot:P9WN79"
/inference="protein motif:PROSITE:PS00978"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46121.1"
/translation="MSNPIQAPDGGQGWPAAALGPAQRAVAWKRLGTEQFDVVVIGGG
VVGSGCALDAATRGLKVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALYE
RELSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLGGAKSVPAQRHFTRAG
ALRLSPGLKRSSLIGGIRYYDTVVDDARHTMTVARTAAHYGAVVRCSTQVVALLREGD
RVIGVGVRDSENGAVAEVRGHVVVNATGVWTDEIQALSKQRGRFQVRASKGVHVVVPR
DRIVSDVAMILRTEKSVMFVIPWGSHWIIGTTDTDWNLDLAHPAATKADIDYILGTVN
AVLATPLTHADIDGVYAGLRPLLAGESDDTSKLSREHAVAVPAAGLVAIAGGKYTTYR
VMAADAIDAAVQFIPARVAPSITEKVSLLGADGYFALVNQAEHVGALQGLHPYRVRHL
LDRYGSLISDVLAMAASDPSLLSPITEAPGYLKVEAAYAAAAEGALHLEDILARRMRI
SIEYPHRGVDCAREVAEVVAPVLGWTAADIDREVANYMARVEAEVLSQAQPDDVSADM
LRASAPEARAEILEPVPLD"
gene complement(3689457..3690938)
/gene="lpdA"
/locus_tag="Rv3303c"
CDS complement(3689457..3690938)
/codon_start=1
/transl_table=11
/gene="lpdA"
/locus_tag="Rv3303c"
/product="NAD(P)H quinone reductase LpdA"
/note="Rv3303c, (MTV016.02c), len: 493 aa. Probable
lpdA,quinone reductase, similar to e.g. Q9EWV3|2SCK31.22c
putative oxidoreductase from Streptomyces coelicolor (475
aa), FASTA scores: opt: 1420, E(): 2.4e-77, (54.9%
identity in 471 aa overlap); Q9A7J2|CC1731 lipoamide
dehydrogenase (E3 component,pyruvate dehydrogenase
complex) from Caulobacter crescentus (466 aa), FASTA
scores: opt: 696,E(): 3.6e-34, (29.6% identity in 463 aa
overlap); Q04829|LPD|DLDH_HALVO dihydrolipoamide
dehydrogenase from Halobacterium volcanii (Haloferax
volcanii) (474 aa), FASTA scores: opt: 675, E(): 6.5e-33,
(29.3% identity in 471 aa overlap); P50970|DLDH_ZYMMO|LPD
dihydrolipoamide dehydrogenase from Zymomonas mobilis,
FASTA scores: opt: 658, E(): 6.6e-32, (30.4% identity in
464 aa overlap); etc. Belongs to the pyridine
nucleotide-disulfide oxidoreductases class-I. Cofactor:
FAD."
/db_xref="EnsemblGenomes-Gn:Rv3303c"
/db_xref="EnsemblGenomes-Tr:CCP46122"
/db_xref="GOA:P9WHH7"
/db_xref="InterPro:IPR001100"
/db_xref="InterPro:IPR004099"
/db_xref="InterPro:IPR016156"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="PDB:1XDI"
/db_xref="UniProtKB/Swiss-Prot:P9WHH7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46122.1"
/translation="MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAV
LDDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADIT
AQLLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILP
SAQPDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVL
PYEDADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIG
SVPNTSGLGLERVGIQLGRGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRI
AMYHALGEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARA
KMSEMRHGFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVY
PSLSGSITEAARRLMAHDDLDCTAAQDAAEQLALVPHHLPTSN"
gene 3691141..3691620
/locus_tag="Rv3304"
CDS 3691141..3691620
/codon_start=1
/transl_table=11
/locus_tag="Rv3304"
/product="Conserved protein"
/note="Rv3304, (MTV016.03), len: 159 aa. Conserved
protein,very similar to Q9CCL6|ML0711 hypothetical protein
from Mycobacterium leprae (159 aa), FASTA scores: opt:
1041,E(): 6.1e-62, (91.8% identity in 159 aa overlap); and
Q49927|L308_F3_97 from M. leprae (174 aa), FASTA scores:
opt: 974, E(): 1.8e-57, (91.2% identity in 149 aa
overlap). Also highly similar to Q9AD81|SCK13.10c
conserved hypothetical protein from Streptomyces
coelicolor (145 aa),FASTA scores: opt: 615, E(): 7.8e-34,
(60.55% identity in 147 aa overlap); and shows some
similarity to other various hypotheticals proteins. ORF
continues upstream with possible start at 2198 (equivalent
to AAK47746 from Mycobacterium tuberculosis strain CDC1551
(212 aa) but shorter 53 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3304"
/db_xref="EnsemblGenomes-Tr:CCP46123"
/db_xref="GOA:O53356"
/db_xref="InterPro:IPR013024"
/db_xref="InterPro:IPR017939"
/db_xref="InterPro:IPR036568"
/db_xref="UniProtKB/TrEMBL:O53356"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46123.1"
/translation="MPLYAAYGSNMHPEQMLERAPHSPMAGTGWLPGWRLTFGGEDIG
WEGALATVVEDPDSKVFVVLYDMTPADEKNLDRWEGSEFGIHQKIRCRVERISSDTTT
DPVLAWLYVLDAWEGGLPSARYLGVMADAAEIAGAPSDYVHDLRTRPARNIGPGTIA"
gene complement(3691639..3692808)
/gene="amiA1"
/gene_synonym="amiA"
/locus_tag="Rv3305c"
CDS complement(3691639..3692808)
/codon_start=1
/transl_table=11
/gene="amiA1"
/gene_synonym="amiA"
/locus_tag="Rv3305c"
/product="Possible N-acyl-L-amino acid amidohydrolase
AmiA1 (N-acyl-L-amino acid aminohydrolase)"
/note="Rv3305c, (MTV016.04c), len: 389 aa. Possible
amiA1,N-acyl-L-amino acid amidohydrolase (or peptidase),
similar to many proteins e.g. Q9AK43|2SCK8.09 putative
peptidase from Streptomyces coelicolor (410 aa), FASTA
scores: opt: 1015, E(): 3.9e-54, (50.8% identity in 374 aa
overlap); Q9UZ30|PAB0873 amino acid amidohydrolase from
Pyrococcus abyssi (383 aa), FASTA scores: opt: 823, E():
1.6e-42,(38.2% identity in 369 aa overlap); O58453|PH0722
long hypothetical amino acid amidohydrolase from
Pyrococcus horikoshii (388 aa), FASTA scores: opt: 815,
E(): 4.8e-42,(38.75% identity in 369 aa overlap);
O34980|YTNL_BACSU hypothetical 45.2 KDA protein from B.
subtilis (416 aa),FASTA scores: opt: 805, E(): 2.1e-41,
(37.85% identity in 367 aa overlap); Q9KCF8|BH1613
N-acyl-L-amino acid amidohydrolase from Bacillus
halodurans (404 aa), FASTA scores: opt: 795, E(): 8.1e-41,
(37.7% identity in 382 aa overlap); BAB50445|MLR3583
hypothetical hippurate hydrolase from Rhizobium loti
(Mesorhizobium loti) (387 aa), FASTA scores: opt: 761,
E(): 8.9e-39, (37.65% identity in 385 aa overlap);
Q9RXH4|DR0339 putative N-acyl-L-amino acid amidohydrolase
from Deinococcus radiodurans (392 aa), FASTA scores: opt:
745, E(): 8.4e-38, (36.15% identity in 379 aa overlap);
etc. Contains PS00639 Eukaryotic thiol (cysteine)
proteases histidine active site. Note that previously
known as amiA."
/db_xref="EnsemblGenomes-Gn:Rv3305c"
/db_xref="EnsemblGenomes-Tr:CCP46124"
/db_xref="GOA:L7N663"
/db_xref="InterPro:IPR002933"
/db_xref="InterPro:IPR017439"
/db_xref="InterPro:IPR036264"
/db_xref="UniProtKB/TrEMBL:L7N663"
/inference="protein motif:PROSITE:PS00639"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46124.1"
/translation="MSLADAAESWLAAHHDDLVGWRRHIHRYPELGRQEYATTQFVAE
RLADAGLNPKVLPGGTGLTCDFGPQHQPRIALRADMDALPMAERTGAPYASTMPNVAH
ACGHDAHTAILLGAALALASVPELPVGVRLIFQAAEELMPGGAIDAIAAGALAGVSRI
FALHCDPRLEVGKVAVRQGPITSAADSIEITLYSPGGHTSRPHLTADLVYGLGTLVTG
LPGVLSRRIDPRNSTVLVWGAVNAGMAANAIPQTGVLSGTVRTASRQTWVDLEELVRQ
AISALLLPLAIEHTLQYRRGVPPVVNEEISTRILAHAIEAIGPGVLADTRQSGGGEDF
SWYLEEVPGAMARLGVWSGDGLQLDLHQPTFDIDERALAIGLRVMVNIIEQAAAH"
gene complement(3692805..3693989)
/gene="amiB1"
/gene_synonym="amiB"
/locus_tag="Rv3306c"
CDS complement(3692805..3693989)
/codon_start=1
/transl_table=11
/gene="amiB1"
/gene_synonym="amiB"
/locus_tag="Rv3306c"
/product="Probable amidohydrolase AmiB1 (aminohydrolase)"
/note="Rv3306c, (MTV016.05c), len: 394 aa. Probable
amiB1,aminohydrolase, similar to several belonging to
peptidase family M40 (and to hypothetical proteins) e.g.
P54983|AMHX_BACSU amidohydrolase AMHX from Bacillus
subtilis (389 aa), FASTA scores: opt: 286, E():
9.9e-10,(26.6% identity in 351 aa overlap);
P76052|ABGB_ECOLI Aminobenzoyl-glutamate utilizatio from
Escherichia coli (481 aa), FASTA scores: opt: 383, E():
2.1e-15, (30.5% identity in 328 aa overlap);
P44765|YDAJ_HAEIN hypothetical protein HI0584 from
Haemophilus influenzae (423 aa), FASTA scores: opt: 297,
E(): 2.4e-10, (29.6% identity in 274 aa overlap). Note
that previously known as amiB."
/db_xref="EnsemblGenomes-Gn:Rv3306c"
/db_xref="EnsemblGenomes-Tr:CCP46125"
/db_xref="GOA:L7N690"
/db_xref="InterPro:IPR002933"
/db_xref="InterPro:IPR011650"
/db_xref="InterPro:IPR017144"
/db_xref="InterPro:IPR017439"
/db_xref="InterPro:IPR036264"
/db_xref="UniProtKB/TrEMBL:L7N690"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46125.1"
/translation="MPAASASDRVEELVRRRGGELVELSHAIHAEPELAFAEHRSCAK
AQALVAERGFEITTAAGGLDTAFRADYGSGPLVVGVCAEYDALPGIGHACGHNIIAAS
AVGTALALAEVADDLGLTVALLGTPAEESGGGKALMLQAGTFDDVAVAVMVHPGPTDI
AGARSLALSEVTVRYRGKESHAAVAPHLGVNAADAVTVAQVAIGVLRQQLAPGQMVHG
IVTDGGQAVNVIPGQARLQYAMRAVESDSLRELQTRMFACFAAGALAAGCEYEIDEAA
PAYAELKPDPWLADVCREEMQRLGREPLLPALEAELPLGSTDMGNVTQVLPGIHPVIG
LDAGAATVHQRAFTVASAGASADRAVVDGAIMLARTVVRLAQTPDERDRVLAAQQRRA
AR"
gene 3694054..3694860
/gene="deoD"
/gene_synonym="punA"
/locus_tag="Rv3307"
CDS 3694054..3694860
/codon_start=1
/transl_table=11
/gene="deoD"
/gene_synonym="punA"
/locus_tag="Rv3307"
/product="Probable purine nucleoside phosphorylase DeoD
(inosine phosphorylase) (PNP)"
/note="Rv3307, (MTV016.06), len: 268 aa. Probable deoD
(alternate gene name: punA), purine nucleoside
phosphorylase, similar to others especially
P46862|PUNA_MYCLE|DEOD_MYCLE|ML0707|L308_F2_56 from M.
leprae (268 aa), FASTA scores: opt: 1373, E():
1.5e-74,(82.05% identity in 262 aa overlap);
Q9EWV2|2SCK31.24 from Streptomyces coelicolor (274 aa),
FASTA scores: opt: 1026,E(): 6.4e-54, (60.5% identity in
266 aa overlap); P81989|PUNA_CELSP from Cellulomonas sp
(282 aa), FASTA scores: opt: 963, E(): 3.6e-50, (58.9%
identity in 270 aa overlap); Q9X1T2|TM1596 from Thermotoga
maritima (265 aa),FASTA scores: opt: 584, E(): 1.1e-27,
(39.55% identity in 263 aa overlap); etc. Belongs to the
PNP/MTAP family 2 of phosphorylases."
/db_xref="EnsemblGenomes-Gn:Rv3307"
/db_xref="EnsemblGenomes-Tr:CCP46126"
/db_xref="GOA:P9WP01"
/db_xref="InterPro:IPR000845"
/db_xref="InterPro:IPR011268"
/db_xref="InterPro:IPR011269"
/db_xref="InterPro:IPR018099"
/db_xref="InterPro:IPR035994"
/db_xref="PDB:1G2O"
/db_xref="PDB:1I80"
/db_xref="PDB:1N3I"
/db_xref="PDB:3IOM"
/db_xref="PDB:3SCZ"
/db_xref="UniProtKB/Swiss-Prot:P9WP01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46126.1"
/translation="MADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAA
LGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVH
PVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAY
SPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARA
AGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF"
gene 3694864..3696468
/gene="pmmB"
/locus_tag="Rv3308"
CDS 3694864..3696468
/codon_start=1
/transl_table=11
/gene="pmmB"
/locus_tag="Rv3308"
/product="Probable phosphomannomutase PmmB (phosphomannose
mutase)"
/note="Rv3308, (MTV016.07), len: 534 aa. Probable
pmmB,phosphomannomutase, equivalent to Q9CCL7|PMMB|ML0706
putative phospho-sugar mutase from Mycobacterium leprae
(538 aa), FASTA scores: opt: 2681, E(): 1.4e-150, (76.95%
identity in 538 aa overlap). Also similar to others e.g.
Q9AD82|SCK13.08c from Streptomyces coelicolor (549
aa),FASTA scores: opt: 1378, E(): 8.9e-74, (46.7% identity
in 529 aa overlap); Q9ZHL4|PMM (fragment so no homology at
N-terminus for this one) from Haemophilus ducreyi (443
aa),FASTA scores: opt: 935, E(): 9.6e-48, (39.4% identity
in 449 aa overlap); P18159|YHXB_BACSU from Bacillus
subtilis (565 aa), FASTA scores: opt: 776, E(): 2.7e-38,
(31.7% identity in 574 aa overlap); etc. Contains PS00710
Phosphoglucomutase and phosphomannomutase phosphoserine
signature. Belongs to the phosphohexose mutases family."
/db_xref="EnsemblGenomes-Gn:Rv3308"
/db_xref="EnsemblGenomes-Tr:CCP46127"
/db_xref="GOA:O53360"
/db_xref="InterPro:IPR005841"
/db_xref="InterPro:IPR005843"
/db_xref="InterPro:IPR005844"
/db_xref="InterPro:IPR005845"
/db_xref="InterPro:IPR005846"
/db_xref="InterPro:IPR016055"
/db_xref="InterPro:IPR016066"
/db_xref="InterPro:IPR036900"
/db_xref="UniProtKB/TrEMBL:O53360"
/inference="protein motif:PROSITE:PS00710"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46127.1"
/translation="MTPENWIAHDPDPQTAAELAACGPDELKARFSRPLAFGTAGLRG
HLRGGPDAMNLAVVLRATWAVARVLTDRGLAGSPVIVGRDARHGSPAFAAAAAEVLAA
AGFSVLLLPDPAPTPVVAFAVRHTGAAAGIQITASHNPATDNGYKVYVDGGLQLLAPT
DRQIEAAMATAPPADQIARKTVNPSENRASDLIDRYIQRAAGVRRCAGSVRVALTPLH
GVGGAMAVETLRRAGFTEVHTVATQFAPNPDFPTVTLPNPEEPGATDALLTLATDVDA
DVAIALDPDADRCAVGIPTVSGWRMLSGDETGWLLGDYILSQTDDRASPPETRVVAST
VVSSRMLAAIAAHHAAVHVETLTGFKWLARADANLPGTLVYAYEEAIGHCVDPTAVRD
KDGISAAVLVCDLVAALKGQGRSVTDALDELARCYGVHEVAALSRPVSGAVETTDLMR
RLREDPPRRLAGFPATVTDIGDTLILTGGDDNMLVRVAVRPSGTEPKLKCYLEIRCAV
TGDLPAARQLVRARIDELSASVRRWW"
gene complement(3696470..3697093)
/gene="upp"
/locus_tag="Rv3309c"
CDS complement(3696470..3697093)
/codon_start=1
/transl_table=11
/gene="upp"
/locus_tag="Rv3309c"
/product="Probable uracil phosphoribosyltransferase Upp
(UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)"
/note="Rv3309c, (MTV016.08c), len: 207 aa. Probable
upp,uracil phosphoribosyltransferase, identical to
P94928|UPP uracil phosphoribosyltransferase from
Mycobacterium bovis (207 aa). Also similar to others e.g.
P36399|UPP_STRSL from Streptococcus salivarius (209 aa),
FASTA scores: opt: 658,E(): 4.7e-35, (48.3% identity in
207 aa overlap); Q9A194|UPP|SPY0392 from Streptococcus
pyogenes (209 aa),FASTA scores: opt:650, E(): 1.5e-34,
(47.35% identity in 207 aa overlap); Q9RE01|UPP from
Lactobacillus plantarum (209 aa), FASTA scores: opt: 644,
E(): 3.7e-34, (46.4% identity in 207 aa overlap); etc.
Belongs to the uprtase family."
/db_xref="EnsemblGenomes-Gn:Rv3309c"
/db_xref="EnsemblGenomes-Tr:CCP46128"
/db_xref="GOA:P9WFF3"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR005765"
/db_xref="InterPro:IPR029057"
/db_xref="InterPro:IPR034332"
/db_xref="PDB:5E38"
/db_xref="UniProtKB/Swiss-Prot:P9WFF3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46128.1"
/translation="MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEAT
RDAPCEPVPIRTPLAETVGSRLTKPPLLVPVLRAGLGMVDEAHAALPEAHVGFVGVAR
DEQTHQPVPYLDSLPDDLTDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVA
APEGIAALQKAAPNVRLFTAAIDEGLNEVAYIVPGLGDAGDRQFGPR"
gene 3697198..3698097
/gene="sapM"
/locus_tag="Rv3310"
CDS 3697198..3698097
/codon_start=1
/transl_table=11
/gene="sapM"
/locus_tag="Rv3310"
/product="Acid phosphatase (acid phosphomonoesterase)
(phosphomonoesterase) (glycerophosphatase)"
/note="Rv3310, (MTV016.09), sapM, len: 299 aa. Secreted
acid phosphatase, with N-terminal sequence beginning with
ASAL..., (see Saleh and Belisle, 2000). Similar to several
fungal or bacterial acid phosphatases e.g.
BAB50846|MLR4110 from Rhizobium loti (Mesorhizobium loti)
(292 aa), FASTA scores: opt: 460, E(): 4.8e-22, (38.65%
identity in 295 aa overlap); P34724|PHOA_ASPNG from
Aspergillus niger (417 aa), FASTA scores: opt: 172, E():
0.0013, (29.1% identity in 306 aa overlap);
P08540|PHOX_KLULA from Kluyveromyces lactis (Yeast) (421
aa), FASTA scores: opt: 170, E(): 0.0018, (27.8% identity
in 266 aa overlap); P37274|PHOA_PENCH from Penicillium
chrysogenum (412 aa),FASTA scores: opt: 163, E(): 0.0049,
(29.05% identity in 303 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3310"
/db_xref="EnsemblGenomes-Tr:CCP46129"
/db_xref="GOA:O53361"
/db_xref="InterPro:IPR007312"
/db_xref="InterPro:IPR017850"
/db_xref="UniProtKB/Swiss-Prot:O53361"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46129.1"
/translation="MLRGIQALSRPLTRVYRALAVIGVLAASLLASWVGAVPQVGLAA
SALPTFAHVVIVVEENRSQAAIIGNKSAPFINSLAANGAMMAQAFAETHPSEPNYLAL
FAGNTFGLTKNTCPVNGGALPNLGSELLSAGYTFMGFAEDLPAVGSTVCSAGKYARKH
VPWVNFSNVPTTLSVPFSAFPKPQNYPGLPTVSFVIPNADNDMHDGSIAQGDAWLNRH
LSAYANWAKTNNSLLVVTWDEDDGSSRNQIPTVFYGAHVRPGTYNETISHYNVLSTLE
QIYGLPKTGYATNAPPITDIWGD"
gene 3698121..3699383
/locus_tag="Rv3311"
CDS 3698121..3699383
/codon_start=1
/transl_table=11
/locus_tag="Rv3311"
/product="Conserved protein"
/note="Rv3311, (MTV016.10), len: 420 aa. Conserved
protein,equivalent to Mycobacterium leprae hypothetical
proteins Q9CCL8|ML0703 (423 aa), FASTA scores: opt: 2185,
E(): 5.5e-120, (77.55% identity in 423 aa overlap);
Q49918|L308_F2_61 (167 aa), FASTA scores: opt: 929, E():
3.5e-47, (84.4% identity in 167 aa overlap) (similarity at
C-terminus for this one); and Q49914|L308_F1_17 (166
aa),FASTA scores: opt: 900, E(): 1.7e-45, (79.0% identity
in 162 aa overlap) (similarity at N-terminus for this
one); Q49923|U0308N (86 aa) FASTA scores: opt: 149, E():
0.052,(48.35% identity in 60 aa overlap); etc. Note that
the Rv3311 corresponding protein in Mycobacterium leprae
is similar to products of two adjacent ORFs. Also some
similarity to Q9XI61|F9L1.1 hypothetical protein from
Arabidopsis thaliana (Mouse-ear cress) (523 aa), FASTA
scores: opt: 134, E(): 1.8, (25.1% identity in 203 aa
overlap). Equivalent to AAK47753 from Mycobacterium
tuberculosis strain CDC1551 (431 aa) but shorter 12 aa. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3311"
/db_xref="EnsemblGenomes-Tr:CCP46130"
/db_xref="UniProtKB/TrEMBL:O53362"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46130.1"
/translation="MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYG
FESVSDLVAFVRTDTENDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPT
AESVAALAASLAIVSAIGSVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSI
AEVIGRSWDDVLAAIDEIISTPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQE
AAESDDEEADAPGDSVVLGGDRDFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGR
NGRISVFGSERALARYLADEHDHDLSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGL
VDDFADGPDAVDREQLDLAVELLRDIGDYSEDSAVDKALETTRPLGQLVAYVLDPHSV
GKPTAPYAAAVREWEKLERFVESRLRRE"
gene complement(3699404..3700330)
/locus_tag="Rv3312c"
CDS complement(3699404..3700330)
/codon_start=1
/transl_table=11
/locus_tag="Rv3312c"
/product="Conserved hypothetical protein"
/note="Rv3312c, (MTV016.11), len: 308 aa. Hypothetical
protein, similar to various proteins (principally
hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7
hypothetical protein from Arabidopsis thaliana (Mouse-ear
cress) (326 aa), FASTA scores: opt: 261, E():
2.6e-09,(27.55% identity in 323 aa overlap); Q9FWB6
putative alpha/beta hydrolase from Oryza sativa (Rice)
(354 aa),FASTA scores: opt: 241, E(): 4.9e-08, (28.9%
identity in 301 aa overlap) (note that Q9FWB6 correspond
to Q9FWB5 putative alpha/beta hydrolase (353 aa) but
longer 1 aa; and to Q9AUW9 hypothetical protein (332 aa)
but longer 22 aa); Q9M382|F24B22.200 hypothetical protein
from Arabidopsis thaliana (Mouse-ear cress) (342 aa),
FASTA scores: opt: 222, E(): 8e-07, (27.6% identity in 319
aa overlap); Q9HWM9|PA4152 probable hydrolase from
Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 176,
E(): 0.00071,(29.2% identity in 209 aa overlap); Q9L3R2
hydrolase from Rhizobium leguminosarum (261 aa), FASTA
scores: opt: 174,E(): 0.00071, (28.9% identity in 173 aa
overlap); P49323|PRXC_STRLI|CPO|CPOL non-heme
chloroperoxidase from Streptomyces lividans (275 aa),
FASTA scores: opt: 172,E(): 0.001, (30.9% identity in 194
aa overlap) (similarity only at N-terminus for this one);
etc. Some similarity in N-terminal part to non-heme
chloroperoxidases. Also similar to
O05293|Rv1191|MTCI364.03 hypothetical protein from M.
tuberculosis (304 aa), FASTA scores: opt: 417, E():
3.1e-19, (32.6% identity in 279 aa overlap) (note that
Rv1191 is equivalent to AAK45485 from Mycobacterium
tuberculosis strain CDC1551 but shorter 14 aa, and that
AAK45485 is annoted Hydrolase, alpha/beta hydrolase
family)."
/db_xref="EnsemblGenomes-Gn:Rv3312c"
/db_xref="EnsemblGenomes-Tr:CCP46131"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53363"
/protein_id="CCP46131.1"
/translation="MTGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFYF
HGTPSSRLEGAFADGAARRTGFRLIAIDRPGYGRSTFQAGRNFRDWPADVCALADAFE
LEEFGVVGHSGAGPHLFACGAVIPRTRLAFVGALGPWGPLATPDIMRSLNAADRCYAR
LARSGPRLFGALFAPLGWCAKYTPGLFSTLLAAAVPAADKHLLSDERFGRHLRAIQLE
AFRQGSRGAAYESFLQFRPWGFDLAEVAVPTHIWLGDRDSFVPRAMGEYLQRAIPHVD
LHWAHGKGHFNIEDWDAILAACALDIGKRRGG"
gene complement(3700705..3701016)
/locus_tag="Rv3312A"
CDS complement(3700705..3701016)
/codon_start=1
/transl_table=11
/locus_tag="Rv3312A"
/product="Secreted protein antigen"
/note="Rv3312A, len: 103 aa. Secreted protein
antigen,described in Corixa patent as having N-terminal
sequence YYWCPGQPFDPAWGP. Equivalent to AAK47756 from
Mycobacterium tuberculosis strain CDC1551 (114 aa) but
shorter 11 aa."
/db_xref="EnsemblGenomes-Gn:Rv3312A"
/db_xref="EnsemblGenomes-Tr:CCP46132"
/db_xref="GOA:P9WI87"
/db_xref="UniProtKB/Swiss-Prot:P9WI87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46132.1"
/translation="MYRFACRTLMLAACILATGVAGLGVGAQSAAQTAPVPDYYWCPG
QPFDPAWGPNWDPYTCHDDFHRDSDGPDHSRDYPGPILEGPVLDDPGAAPPPPAAGGG
A"
gene complement(3701087..3702184)
/gene="add"
/locus_tag="Rv3313c"
CDS complement(3701087..3702184)
/codon_start=1
/transl_table=11
/gene="add"
/locus_tag="Rv3313c"
/product="Probable adenosine deaminase Add (adenosine
aminohydrolase)"
/note="Rv3313c, (MTV016.13), len: 365 aa. Probable
add,adenosine deaminase, equivalent to Q9CCL9|add|ML0700
putative adenosine deaminase from Mycobacterium leprae
(362 aa), FASTA scores: opt: 2097, E(): 1.4e-127, (88.2%
identity in 356 aa overlap). Also similar to many e.g.
Q9AK25|2SCK8.27 from Streptomyces coelicolor (396
aa),FASTA scores: opt: 1578, E(): 3.7e-94, (66.65%
identity in 360 aa overlap); Q17747|C06G3.5 from
Caenorhabditis elegans (349 aa), FASTA scores: opt: 435,
E(): 1.1e-20, (29.6% identity in 348 aa overlap);
P22333|ADD_ECOLI|B1623 from Escherichia coli strain K12
(333 aa), FASTA scores: opt: 380, E(): 3.7e-17, (29.4%
identity in 340 aa overlap); etc. Belongs to the adenosine
and AMP deaminases family."
/db_xref="EnsemblGenomes-Gn:Rv3313c"
/db_xref="EnsemblGenomes-Tr:CCP46133"
/db_xref="GOA:P63907"
/db_xref="InterPro:IPR001365"
/db_xref="InterPro:IPR006330"
/db_xref="InterPro:IPR028893"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/Swiss-Prot:P63907"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46133.1"
/translation="MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLP
ATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVY
AEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSR
EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSI
HEAIAFCGADRLGHGVRIVDDIDVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGA
VASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNA
MKSAFIPFDQRLAIIDEVIKPRFAALMGHSE"
gene complement(3702184..3703467)
/gene="deoA"
/locus_tag="Rv3314c"
CDS complement(3702184..3703467)
/codon_start=1
/transl_table=11
/gene="deoA"
/locus_tag="Rv3314c"
/product="Probable thymidine phosphorylase DeoA (tdrpase)
(pyrimidine phosphorylase)"
/note="Rv3314c, (MTV016.14), len: 427 aa. Probable
deoA,thymidine phosporylase, highly similar to many e.g.
Q9AK36|DEOA from Streptomyces coelicolor (427 aa), FASTA
scores: opt: 1668, E(): 3.2e-90, (62.35% identity in 425
aa overlap); Q9CFM5|PDP from Lactococcus lactis (subsp.
lactis) (Streptococcus lactis) (430 aa), FASTA scores:
opt: 1031, E(): 5.5e-53, (46.45% identity in 392 aa
overlap); P19971|TYPH_HUMAN|ECGF1 from Homo sapiens
(Human) (482 aa),FASTA scores: opt: 957, E(): 1.3e-48,
(44.45% identity in 441 aa overlap);
P07650|TYPH_ECOLI|DEOA|TPP|TTG|B4382 from Escherichia coli
strain K12 (440 aa), FASTA scores: opt: 847, E(): 3.2e-42,
(41.55% identity in 438 aa overlap); etc. Contains PS00647
Thymidine and pyrimidine-nucleoside phosphorylases
signature. Belongs to the thymidine/pyrimidine-nucleoside
phosphorylases family."
/db_xref="EnsemblGenomes-Gn:Rv3314c"
/db_xref="EnsemblGenomes-Tr:CCP46134"
/db_xref="GOA:P9WFS1"
/db_xref="InterPro:IPR000053"
/db_xref="InterPro:IPR000312"
/db_xref="InterPro:IPR013102"
/db_xref="InterPro:IPR017459"
/db_xref="InterPro:IPR017872"
/db_xref="InterPro:IPR018090"
/db_xref="InterPro:IPR035902"
/db_xref="InterPro:IPR036320"
/db_xref="InterPro:IPR036566"
/db_xref="UniProtKB/Swiss-Prot:P9WFS1"
/inference="protein motif:PROSITE:PS00647"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46134.1"
/translation="MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMS
ALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVP
VVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQ
LAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQA
RELAHTMVELGAAHGVPTRALLTEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELT
LRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLSKPLPIGSHSETVTAG
ASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYT
NAPERFGAARAELAGGWSIRDSPPQVRPLIVDRIV"
gene complement(3703464..3703865)
/gene="cdd"
/locus_tag="Rv3315c"
CDS complement(3703464..3703865)
/codon_start=1
/transl_table=11
/gene="cdd"
/locus_tag="Rv3315c"
/product="Probable cytidine deaminase Cdd (cytidine
aminohydrolase) (cytidine nucleoside deaminase)"
/note="Rv3315c, (MTV016.15c), len: 133 aa. Probable
cdd,cytidine deaminase, equivalent to Q9CBD3|CDD|ML2174
cytidine deaminase from Mycobacterium leprae (134
aa),FASTA scores: opt: 516, E(): 5.8e-28, (56.8% identity
in 132 aa overlap). Also highly similar to many e.g.
Q9AK37|2SCK8.15 from Streptomyces coelicolor (130
aa),FASTA scores: opt: 523, E(): 1.9e-28, (60.0% identity
in 130 aa overlap); Q9KD53|CDD|BH1366 from Bacillus
halodurans (132 aa), FASTA scores: opt: 305, E(): 9.2e-14,
(41.55% identity in 130 aa overlap);
P56389|CDD_MOUSE|CDA|CDD from Mus musculus (Mouse) (146
aa), FASTA scores: opt: 287, E(): 1.6e-12, (40.3% identity
in 124 aa overlap); P19079|CDD_BACSU (136 aa), FASTA
scores: opt: 270, E(): 2.1e-11, (28.6% identity in 127 aa
overlap); etc. Contains PS00903 Cytidine and
deoxycytidylate deaminases zinc-binding region signature.
Belongs to the cytidine and deoxycytidylate deaminases
family. Cofactor: zinc (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3315c"
/db_xref="EnsemblGenomes-Tr:CCP46135"
/db_xref="GOA:P9WPH3"
/db_xref="InterPro:IPR002125"
/db_xref="InterPro:IPR016193"
/db_xref="PDB:3IJF"
/db_xref="PDB:4WIF"
/db_xref="PDB:4WIG"
/db_xref="UniProtKB/Swiss-Prot:P9WPH3"
/inference="protein motif:PROSITE:PS00903"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46135.1"
/translation="MPDVDWNMLRGNATQAAAGAYVPYSRFAVGAAALVDDGRVVTGC
NVENVSYGLTLCAECAVVCALHSTGGGRLLALACVDGHGSVLMPCGRCRQVLLEHGGS
ELLIDHPVRPRRLGDLLPDAFGLDDLPRERR"
gene 3704102..3704440
/gene="sdhC"
/locus_tag="Rv3316"
CDS 3704102..3704440
/codon_start=1
/transl_table=11
/gene="sdhC"
/locus_tag="Rv3316"
/product="Probable succinate dehydrogenase (cytochrome
B-556 subunit) SdhC (succinic dehydrogenase) (fumarate
reductase) (fumarate dehydrogenase) (fumaric hydrogenase)"
/note="Rv3316, (MTV016.16), len: 112 aa. Probable
sdhC,cytochrome B-556 of succinate dehydrogenase SdhC
subunit ,transmembrane protein, equivalent (but shorter 35
aa) to Q9CCM0|SDHC|ML0699 putative succinate dehydrogenase
cytochrome B-556 subunit from Mycobacterium leprae (153
aa), FASTA scores: opt: 692, E(): 1.2e-39, (88.4% identity
in 112 aa overlap). Also similar to others e.g.
Q9KZ88|SC5G8.26c from Streptomyces coelicolor (126
aa),FASTA scores: opt: 484, E(): 8.3e-26, (65.65% identity
in 99 aa overlap); Q9RVR8|DR0954 from Deinococcus
radiodurans (118 aa), FASTA scores: opt: 195, E():
1.7e-06, (36.8% identity in 87 aa overlap);
Q9HQ63|DHSD_HALN1|SDHD|SDHC|VNG1310G from Halobacterium
sp. strain NRC-1 (130 aa), FASTA scores: opt: 192, E():
2.9e-06, (37.85% identity in 74 aa overlap);
P72109|DHSD_NATPH|SDHD|SDHC from Natronomonas pharaonis
(Natronobacterium pharaonis) (130 aa), FASTA scores: opt:
183, E(): 1.1e-05, (35.15% identity in 74 aa overlap);
etc. Part of an enzyme complex containing four subunits: a
flavoprotein, an iron-sulfur, cytochrome B-556, and an
hydrophobic anchor protein. Belongs to the cytochrome B560
family."
/db_xref="EnsemblGenomes-Gn:Rv3316"
/db_xref="EnsemblGenomes-Tr:CCP46136"
/db_xref="GOA:O53368"
/db_xref="InterPro:IPR000701"
/db_xref="InterPro:IPR014314"
/db_xref="InterPro:IPR034804"
/db_xref="InterPro:IPR039023"
/db_xref="UniProtKB/Swiss-Prot:O53368"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46136.1"
/translation="MWSWVCHRISGATIFFFLFVHVLDAAMLRVSPQTYNAVLATYKT
PIVGLMEYGLVAAVLFHALNGIRVILIDFWSEGPRYQRLMLWIIGSVFLLLMVPAGVV
VGIHMWEHFR"
gene 3704437..3704871
/gene="sdhD"
/locus_tag="Rv3317"
CDS 3704437..3704871
/codon_start=1
/transl_table=11
/gene="sdhD"
/locus_tag="Rv3317"
/product="Probable succinate dehydrogenase (hydrophobic
membrane anchor subunit) SdhD (succinic dehydrogenase)
(fumarate reductase) (fumarate dehydrogenase) (fumaric
hydrogenase)"
/note="Rv3317, (MTV016.17), len: 144 aa. Probable
sdhD,membrane anchor of succinate dehydrogenase SdhD
subunit ,equivalent (but shorter 19 aa) to
Q49915|SDHD|ML0698|L308_F1_25 putative succinate
dehydrogenase hydrophobic membrane anchor protein from
Mycobacterium leprae (163 aa), FASTA scores: opt: 878,
E(): 1.9e-51, (85.2% identity in 142 aa overlap). Also
similar to others e.g. Q9KZ89|SC5G8.25c from Streptomyces
coelicolor (160 aa), FASTA scores: opt: 553, E():
6.6e-30,(58.85% identity in 141 aa overlap); Q9RVR9|DR0953
from Deinococcus radiodurans (125 aa), FASTA scores: opt:
251,E(): 5.5e-10, (37.15% identity in 113 aa overlap);
O29573|DHSD_ARCFU|SDHD|AF0684 from Archaeoglobus fulgidus
(117 aa), FASTA scores: opt: 160, E(): 0.00056, (25.95%
identity in 108 aa overlap); etc. Part of an enzyme
complex containing four subunits: a flavoprotein, an
iron-sulfur,cytochrome B-556, and an hydrophobic anchor
protein."
/db_xref="EnsemblGenomes-Gn:Rv3317"
/db_xref="EnsemblGenomes-Tr:CCP46137"
/db_xref="GOA:O53369"
/db_xref="InterPro:IPR000701"
/db_xref="InterPro:IPR034804"
/db_xref="UniProtKB/TrEMBL:O53369"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46137.1"
/translation="MSAPVRQRSHDRPASLDNPRSPRRRAGMPNFEKFAWLFMRFSGV
VLVFLAIGHVFIMLMWDNGVYRLDFNFVAQRWASPFWQTWDLLLLWLAQLHGGNGLRT
IIDDYSRKDTTRFWLNSLLVLSMLFTLMLGTYVIVTFDPNIS"
repeat_region complement(3704895..3705004)
/note="110 bp Mycobacterial Interspersed Repetitive
Unit,Class III"
gene 3705000..3706772
/gene="sdhA"
/locus_tag="Rv3318"
CDS 3705000..3706772
/codon_start=1
/transl_table=11
/gene="sdhA"
/locus_tag="Rv3318"
/product="Probable succinate dehydrogenase (flavoprotein
subunit) SdhA (succinic dehydrogenase) (fumarate
reductase) (fumarate dehydrogenase) (fumaric hydrogenase)"
/note="Rv3318, (MTV016.18), len: 590 aa. Probable
sdhA,flavoprotein of succinate dehydrogenase SdhA
subunit,equivalent to Q9CCM1|SDHA|ML0697 succinate
dehydrogenase flavoprotein subunit from Mycobacterium
leprae (584 aa),FASTA scores: opt: 3657, E(): 1.2e-217,
(92.55% identity in 590 aa overlap). Also highly similar
to others e.g. Q9KZ90|DHSA from Streptomyces coelicolor
(584 aa), FASTA scores: opt: 2813, E(): 1.1e-165, (70.5%
identity in 586 aa overlap); Q9RVS0|DR0952 from
Deinococcus radiodurans (583 aa), FASTA scores: opt: 2203,
E(): 4.1e-128, (57.35% identity in 593 aa overlap);
P31038|DHSA_RICPR|SDHA|RP128 from Rickettsia prowazekii
(596 aa), FASTA scores: opt: 1892, E(): 5.8e-109, (50.0%
identity in 588 aa overlap);
P10444|DHSA_ECOLI|SDHA|B0723|Z0877|ECS0748 from
Escherichia coli strains K12 and O157:H7 (588 aa), FASTA
scores: opt: 1844, E(): 5.2e-106, (48.75% identity in 591
aa overlap); etc. Contains PS00504 Fumarate reductase /
succinate dehydrogenase FAD-binding site. Cofactor: FAD.
Similar to the flavoprotein subunits of other species
succinate dehydrogenase and of fumarate reductase. Part of
an enzyme complex containing four subunits: a
flavoprotein, an iron-sulfur, cytochrome B-556, and an
hydrophobic anchor protein."
/db_xref="EnsemblGenomes-Gn:Rv3318"
/db_xref="EnsemblGenomes-Tr:CCP46138"
/db_xref="GOA:O53370"
/db_xref="InterPro:IPR003952"
/db_xref="InterPro:IPR003953"
/db_xref="InterPro:IPR011281"
/db_xref="InterPro:IPR014006"
/db_xref="InterPro:IPR015939"
/db_xref="InterPro:IPR027477"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR037099"
/db_xref="UniProtKB/TrEMBL:O53370"
/inference="protein motif:PROSITE:PS00504"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46138.1"
/translation="MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHT
GAAQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGM
PFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFN
EFYALDLALTQTPSGPVATGVIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHT
LTGDGIGIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMER
YAPTIVDLAPRDIVARSMVLEVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFA
RTYLGVDPVTELVPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHG
ANRLGTNSLLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEHGNER
VADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHDKGKRFNTDLLEA
IELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKEIGADKEGPE
LRSDVRLDFKPVVQTRYEPKERKY"
gene 3706772..3707563
/gene="sdhB"
/locus_tag="Rv3319"
CDS 3706772..3707563
/codon_start=1
/transl_table=11
/gene="sdhB"
/locus_tag="Rv3319"
/product="Probable succinate dehydrogenase (iron-sulphur
protein subunit) SdhB (succinic dehydrogenase) (fumarate
reductase) (fumarate dehydrogenase) (fumaric hydrogenase)"
/note="Rv3319, (MTV016.19), len: 263 aa. Probable
sdhB,iron-sulphur protein succinate dehydrogenase SdhB
subunit ,equivalent to Q49916|SDHB|ML0696|L308_F1_28
succinate dehydrogenase iron-sulfur protein from
Mycobacterium leprae (264 aa), FASTA scores: opt: 1678,
E(): 4.7e-99, (89.8% identity in 264 aa overlap). Also
highly similar to other e.g. Q9KZ91|DHSB from Streptomyces
coelicolor (257 aa),FASTA scores: opt: 1125, E(): 4.6e-64,
(64.1% identity in 262 aa overlap); Q9RVS1|DR0951 from
Deinococcus radiodurans (264 aa), FASTA scores: opt: 1014,
E(): 5e-57, (57.25% identity in 255 aa overlap);
Q9PEF5|XF1073 from Xylella fastidiosa (261 aa), FASTA
scores: opt: 681, E(): 5.8e-36,(45.1% identity in 244 aa
overlap); P07014|DHSB_ECOLI|SDHB|B0724 from Escherichia
coli strain K12 (238 aa), FASTA scores: opt: 657, E():
1.8e-34, (43.75% identity in 240 aa overlap); etc.
Contains PS00198 4Fe-4S ferredoxins, iron-sulfur binding
region signature. Cofactor: binds three different
iron-sulfur clusters: a 2FE-2S, a 3FE-4S and a 4FE-4S. The
iron-sulfur centers are similar to those of 'plant-type'
2FE-2S and 'bacterial-type' 4FE-4S ferredoxins. Part of an
enzyme complex containing four subunits: a flavoprotein,
an iron-sulfur, cytochrome B-556, and an hydrophobic
anchor protein."
/db_xref="EnsemblGenomes-Gn:Rv3319"
/db_xref="EnsemblGenomes-Tr:CCP46139"
/db_xref="GOA:O53371"
/db_xref="InterPro:IPR004489"
/db_xref="InterPro:IPR009051"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017896"
/db_xref="InterPro:IPR017900"
/db_xref="InterPro:IPR025192"
/db_xref="InterPro:IPR036010"
/db_xref="UniProtKB/TrEMBL:O53371"
/inference="protein motif:PROSITE:PS00198"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46139.1"
/translation="MSVEPDVETLDPPLPPVPDGAVMVTVKIARFNPDDPDAFAATGG
WQSFRVPCLPSDRLLNLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVL
MRDLLPKKKGKSLTVTVEPIRGLPVEKDLVVDMEPFFDAYRAIKPYLITSGNPPTRER
IQSPTDRARYDDTTKCILCACCTTSCPVFWHEGSYFGPAAIVNAHRFIFDSRDEAAAE
RLDILNEVDGVWRCRTTFNCTESCPRGIEVTKAIQEVKRALMFTR"
gene complement(3707642..3708070)
/gene="vapC44"
/locus_tag="Rv3320c"
CDS complement(3707642..3708070)
/codon_start=1
/transl_table=11
/gene="vapC44"
/locus_tag="Rv3320c"
/product="Possible toxin VapC44. Contains PIN domain."
/note="Rv3320c, (MTV016.20c), len: 142 aa. Possible
vapC44,toxin, part of toxin-antitoxin (TA) operon with
Rv0300,contains PIN domain, see Arcus et al. 2005. Similar
to several others in Mycobacterium tuberculosis (strains
H37Rv and CDC1551) e.g. P95023|Rv2530c|MTCY159.26 (139
aa), FASTA scores: opt: 292, E(): 4.8e-14, (41.5% identity
in 135 aa overlap); O53219|Rv2494|MTV008.50 (141 aa),
FASTA scores: opt: 287, E(): 1.1e-13, (41.6% identity in
125 aa overlap); O07760|Rv0617|MTCY19H5.04c (133 aa),
FASTA scores: opt: 252, E(): 3.3e-11, (37.8% identity in
127 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3320c"
/db_xref="EnsemblGenomes-Tr:CCP46140"
/db_xref="GOA:P9WF53"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46140.1"
/translation="MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQN
GFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFWSCTVSILDSKVIDRSRLHSPKQ
VTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL"
gene complement(3708074..3708316)
/gene="vapB44"
/locus_tag="Rv3321c"
CDS complement(3708074..3708316)
/codon_start=1
/transl_table=11
/gene="vapB44"
/locus_tag="Rv3321c"
/product="Possible antitoxin VapB44"
/note="Rv3321c, (MTV016.21c), len: 80 aa. Possible
vapB44,antitoxin, part of toxin-antitoxin (TA) operon with
Rv0299,see Arcus et al. 2005. Similar to several others in
Mycobacterium tuberculosis (strains H37Rv and CDC1551)
e.g. AAK48167|MT3800 DNA-binding protein (COPG family)
from strain CDC1551 (74 aa), FASTA scores: opt: 142, E():
0.0016, (48.85% identity in 43 aa overlap);
AAK46916|MT2606 hypothetical 8.0 KDA protein from strain
CDC1551 (74 aa),FASTA scores: opt: 139, E(): 0.0026,
(37.2% identity in 78 aa overlap); O50456|Rv1241|MTV006.13
hypothetical 9.9 KDA protein from strain H37Rv (86 aa),
FASTA scores: opt: 134,E(): 0.0066, (39.0% identity in 82
aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3321c"
/db_xref="EnsemblGenomes-Tr:CCP46141"
/db_xref="GOA:P9WJ17"
/db_xref="UniProtKB/Swiss-Prot:P9WJ17"
/protein_id="CCP46141.1"
/translation="MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQ
PAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV"
gene complement(3708438..3709052)
/locus_tag="Rv3322c"
CDS complement(3708438..3709052)
/codon_start=1
/transl_table=11
/locus_tag="Rv3322c"
/product="Possible methyltransferase"
/note="Rv3322c, (MTV016.22c), len: 204 aa. Conserved
hypothetical protein, showing weak similarity to proteins
including several methyltransferases e.g. Q9X9V1|ORF8
putative methyltransferase from Streptomyces coelicolor
(208 aa), FASTA scores: opt: 193, E(): 1e-05, (36.35%
identity in 132 aa overlap); and Q9XA90|SCF43A.25c
putative methyltransferase from Streptomyces coelicolor
(215 aa),FASTA scores: opt: 161, E(): 0.0014, (32.05%
identity in 131 aa overlap); P74712|SLR1183 hypothetical
21.3 KDA protein from Synechocystis sp. strain PCC 6803
(194 aa),FASTA scores: opt: 155, E(): 0.0032, (27.35%
identity in 150 aa overlap); Q9ABW8|CC0102 rRNA
methyltransferase RSMB from Caulobacter crescentus (429
aa), FASTA scores: opt: 148, E(): 0.018, (31.5% identity
in 162 aa overlap); etc. Also highly similar to
O05796|Rv3120|MTCY164.30 hypothetical 21.8 KDA protein
from Mycobacterium tuberculosis (200 aa), FASTA scores:
opt: 691, E(): 1.2e-38, (56.5% identity in 200 aa
overlap); and shows weak similarity to
O69667|Rv3699|MTV025.047 putative methyltransferase from
Mycobacterium tuberculosis (233 aa),FASTA scores: opt:
155, E(): 0.0037, (29.15% identity in 168 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3322c"
/db_xref="EnsemblGenomes-Tr:CCP46142"
/db_xref="GOA:L7N687"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:L7N687"
/protein_id="CCP46142.1"
/translation="MSVQTDPALREHPNRVDWNARYERAGSAHAPFAPVPWLADVLRA
GVPDGPVLELASGRSGTALALAAHGRQVTAIDVSDVALLQLDSEAVRRGVADRLNLVQ
ADLGCWEPGETRFALVLSRLFWDAAIFHRACEAVMPGGVLAWESLALSGAEAGTASAK
RRVKPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSPLPGA"
gene complement(3709049..3709714)
/gene="moaX"
/locus_tag="Rv3323c"
CDS complement(3709049..3709714)
/codon_start=1
/transl_table=11
/gene="moaX"
/locus_tag="Rv3323c"
/product="Probable MoaD-MoaE fusion protein MoaX"
/note="Rv3323c, (MTV016.23c), len: 221 aa. Probable
moaX,MoaD-MoaE fusion protein, similar (whole or partial)
to several MoaD and MoaE proteins e.g. Q9RR88|DR2607
molybdenum cofactor biosynthesis protein D/E from
Deinococcus radiodurans (229 aa), FASTA scores: opt:
407,E(): 1.8e-18, (32.75% identity in 223 aa overlap);
Q9K8I7|MOAE|BH3019 molybdopterin converting factor
(subunit 2) from Bacillus halodurans (156 aa), FASTA
scores: opt: 375, E(): 1.3e-16, (41.65% identity in 132 aa
overlap); O31705|MOAE molybdopterin converting factor
(subunit 2) from Bacillus subtilis (157 aa), FASTA scores:
opt: 368,E(): 3.6e-16, (41.65% identity in 132 aa
overlap); etc. C-terminus highly similar to
O05795|MOAE_MYCTU|Rv3119|MT3201|MTCY164.29|MOAE1 putative
molybdenum cofactor biosynthesis protein E from
Mycobacterium tuberculosis (147 aa), FASTA scores: opt:
733, E(): 5.4e-39, (76.2% identity in 143 aa overlap); and
N-terminus highly similar to
O05789|MOAD1|Rv3112|MTCY164.22 putative molybdenum
cofactor biosynthesis protein D from Mycobacterium
tuberculosis (83 aa), FASTA scores: opt: 333,E(): 3.2e-14,
(65.05% identity in 83 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3323c"
/db_xref="EnsemblGenomes-Tr:CCP46143"
/db_xref="GOA:Q6MWY3"
/db_xref="InterPro:IPR003448"
/db_xref="InterPro:IPR003749"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR016155"
/db_xref="InterPro:IPR036563"
/db_xref="UniProtKB/TrEMBL:Q6MWY3"
/protein_id="CCP46143.1"
/translation="MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPP
LADFRKRVRMAVNESIAPASTILDDGDTVAFIPQVAGGSDVYCRLTDEPLSVDEVLNA
ISGPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVA
VAHRTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVA
NRP"
gene complement(3709715..3710248)
/gene="moaC3"
/locus_tag="Rv3324c"
CDS complement(3709715..3710248)
/codon_start=1
/transl_table=11
/gene="moaC3"
/locus_tag="Rv3324c"
/product="Probable molybdenum cofactor biosynthesis
protein C 3 MoaC3"
/note="Rv3324c, (MTV016.24c), len: 177 aa. Probable
moaC3,molybdopterin cofactor biosynthesis protein, highly
similar to others e.g. Q9HX95|MOAC|PA3918 from Pseudomonas
aeruginosa (160 aa), FASTA scores: opt: 567, E():
7.5e-30,(58.35% identity in 156 aa overlap); Q9RKA8|MOAC
from Streptomyces coelicolor (170 aa), FASTA scores: opt:
553,E(): 6.3e-29, (58.25% identity in 158 aa overlap);
P30747|MOAC_ECOLI|CHLA3|B0783 from Escherichia coli strain
K12 (160 aa), FASTA scores: opt: 516, E(): 1.5e-26,
(55.95% identity in 159 aa overlap); etc. Also highly
similar to O05788|MOAC1|Rv3111|MTCY164.21 putative
molybdenum cofactor biosynthesis protein C from
Mycobacterium tuberculosis (170 aa), FASTA scores: opt:
734, E(): 1.3e-40, (71.8% identity in 163 aa overlap); and
Rv0864|MOAC2|MTV043.57 putative molybdenum cofactor
biosynthesis protein (167 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3324c"
/db_xref="EnsemblGenomes-Tr:CCP46144"
/db_xref="GOA:P9WJR5"
/db_xref="InterPro:IPR002820"
/db_xref="InterPro:IPR023045"
/db_xref="InterPro:IPR036522"
/db_xref="UniProtKB/Swiss-Prot:P9WJR5"
/protein_id="CCP46144.1"
/translation="MNDHDGVLTHLDEQGAARMVDVSAKAVTLRRARASGAVLMKPST
LDMICHGTAAKGDVIATARIAGIMAAKRTGELIPLCHPLGIEAVTVTLEPQGADRLSI
AATVTTVARTGVEMEALTAVTVTALTVYDMCKAVDRAMTITDIRLDEKSGGRSGHYRR
HDADVKPSDGGSTEDGC"
gene complement(3710245..3710379)
/pseudo
/locus_tag="Rv3324A"
CDS complement(3710245..3710379)
/codon_start=1
/transl_table=11
/locus_tag="Rv3324A"
/product="Probable fragment of
pterin-4-alpha-carbinolamine dehydratase MOAB3 (PHS)
(4-alpha-hydroxy-tetrahydropterin dehydratase)
(pterin-4-a-carbinolamine dehydratase) (phenylalanine
hydroxylase-stimulating protein) (PHS) (pterin
carbinolamine dehydratase) (PCD)"
/note="Rv3324A, len: 44 aa. Probable pseudogene
moaB3,fragment of pterin-4-alpha-carbinolamine
dehydratase,equivalent to C-terminus of MT3426|Q8VJ32
pterin-4-alpha-carbinolamine dehydratase from
Mycobacterium tuberculosis strain CDC1551 (124 aa), FASTA
scores: opt: 309, E(): 1.1e-20, (100.000% identity in 44
aa overlap),and C-terminus of Mb3354c|moaB3 probable
pterin-4-alpha-carbinolamine dehydratase from
Mycobacterium bovis (124 aa). Note that a deletion of DNA
(RvD5 region) in Mycobacterium tuberculosis strain H37Rv
resulted in a truncated CDS comparatively to Mycobacterium
bovis or Mycobacterium tuberculosis strain CDC1551 genomes
(see citations below)."
/pseudogene="unknown"
mobile_element 3710382..3711736
/mobile_element_type="insertion sequence:IS6110-14"
/note="IS6110-14, len: 1355 nt. Insertion sequence
IS6110."
repeat_region 3710382..3710409
/note="28 bp inverted repeat at left end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene 3710433..3710759
/locus_tag="Rv3325"
CDS 3710433..3710759
/codon_start=1
/transl_table=11
/locus_tag="Rv3325"
/product="Probable transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv3325, (MTV016.25), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv3325 and
Rv3326,the sequence UUUUAAAG (directly upstream of Rv3326)
maybe responsible for such a frameshifting event (see
McAdam et al., 1990). Belongs to the transposase family
8."
/db_xref="EnsemblGenomes-Gn:Rv3325"
/db_xref="EnsemblGenomes-Tr:CCP46146"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP46146.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <3710708..3711694
/locus_tag="Rv3326"
CDS <3710708..3711694
/codon_start=1
/transl_table=11
/locus_tag="Rv3326"
/product="Probable transposase"
/note="Rv3326, (MTV016.26), len: 328 aa. Probable
transposase for insertion element IS6110. Identical to
many other M. tuberculosis IS6110 transposase subunits.
The transposase described here may be made by a frame
shifting mechanism during translation that fuses Rv3325
and Rv3326,the sequence UUUUAAAG (directly upstream of
Rv3326) maybe responsible for such a frameshifting event
(see McAdam et al., 1990). Start changed since first
submission (+ 16 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3326"
/db_xref="EnsemblGenomes-Tr:CCP46147"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP46147.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(3711709..3711736)
/note="28 bp inverted repeat at right end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC"
mobile_element 3711737..3712822
/mobile_element_type="insertion sequence:IS1547-2"
/note="IS1547-2, len: 1086 nt. Region corresponding to
Insertion sequence IS1547, positions 1982 3067 in
EM_NEW:MTY13470."
gene 3711749..3713461
/locus_tag="Rv3327"
CDS 3711749..3713461
/codon_start=1
/transl_table=11
/locus_tag="Rv3327"
/product="Probable transposase fusion protein"
/note="Rv3327, (MTV016.27), len: 570 aa. Probable fusion
protein. Indeed, N-terminal part corresponds to entire
O07269 transposase of IS1547 (383 aa), and C-terminal part
identical to MTCI249B.03c (210 aa). N-terminal part is
identical to MTV042_7 (188 aa); C-terminal part (aa
378-570) is similar to hypothetical 20.5 kDa protein from
Escherichia coli P76222|YNJA_ECOLI (182 aa), FASTA scores:
opt: 292, E(): 5.3e-11, (32.6% identity in 181 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3327"
/db_xref="EnsemblGenomes-Tr:CCP46148"
/db_xref="GOA:O53377"
/db_xref="InterPro:IPR002525"
/db_xref="InterPro:IPR003346"
/db_xref="InterPro:IPR029032"
/db_xref="UniProtKB/TrEMBL:O53377"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46148.1"
/translation="MVVVGTDAHKYSHTFVATDEVGRQLGEKTVKATTAGHATAIMWA
REQFGLELIWGIEDCRNMSARLERDLLAAGQQVVRVPTKLMAQTRKSARSRGKSDPID
ALAVARAVLRETDLPLATHDETSRELKLLTDRRDVLVAQRTSAINRLRWLVHELDPER
APAARSLDAAKHQQALRTWLDTQPGLVAELARAELTDIIRLTGEINTLAQRISARVHQ
VAPALLEIPGCAELTAAKIVGEAAGVTRFKSEAAFACHAAVAPIPVWSGNTAGQMRLS
RSGNRQLNAALHRIALTQIRMTDSRGQAYYQRLQDAGKTKRAALRCLKRRLARTVFQA
LRTVHQPSSEHTQPAAACHRSYCSSHLGEPPRLTDMTQKTRIQPLPPKRAGLLIRALY
RIAKRRFGEVPEPFTVTAHHRRLLIANVVHEALLQRASRKLPPSVRELAVFWTARSIG
CSWCVDFGAMLQRLDGLDVDRLTDIDNYATSSKFSDDERAAIAYAEAMTADPHSVTDE
QVADLRARFGEAGVIELTYQIGVENMRARMNSALGITEQGFNSGDACRVPWAAPDVPS
AESR"
gene complement(3713394..3714332)
/gene="sigJ"
/locus_tag="Rv3328c"
CDS complement(3713394..3714332)
/codon_start=1
/transl_table=11
/gene="sigJ"
/locus_tag="Rv3328c"
/product="Probable alternative RNA polymerase sigma factor
(fragment) SigJ"
/note="Rv3328c, (MTV016.28c), len: 312 aa. Probable
sigJ,alternative RNA polymerase sigma factor (see
citations below), highly similar to many e.g.
Q9K3H7|2SCG18.10c from Streptomyces coelicolor (295 aa),
FASTA scores: opt: 642,E(): 7.3e-31, (42.8% identity in
292 aa overlap); Q9A3D8|CC3266 from Caulobacter crescentus
(291 aa), FASTA scores: opt: 607, E(): 8.4e-29, (39.8%
identity in 294 aa overlap); Q9RD74|SCF43.14c from
Streptomyces coelicolor (324 aa), FASTA scores: opt: 555,
E(): 1.1e-25, (41.1% identity in 297 aa overlap); etc.
Similar also to U00022_20 from Mycobacterium leprae; and
MTCI28_22 and MSU87307_1. Also similar to
O50445|SIGI|Rv1189|MTV005.25|MTCI364.01 putative RNA
polymerase sigma factor from Mycobacterium tuberculosis
(290 aa), FASTA scores: opt: 426, E(): 4.2e-18, (32.65%
identity in 294 aa overlap). Equivalent to AAK47774 from
Mycobacterium tuberculosis strain CDC1551 (282 aa) but
longer 30 aa. Contains probable helix-turn-helix motif at
aa 129-150 (Score 1126, +3.02 SD). Belongs to the sigma-70
factor family, ECF subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3328c"
/db_xref="EnsemblGenomes-Tr:CCP46149"
/db_xref="GOA:L0TCG5"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR037401"
/db_xref="PDB:5XE7"
/db_xref="UniProtKB/Swiss-Prot:L0TCG5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46149.1"
/translation="MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRWDSPDTV
IADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWLPEPVVTGLDATDPLAAVVAAEDA
RFAAMVVLERLRPDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQP
ALISGDPDPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGS
DKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRD
GKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN"
gene 3714392..3715708
/locus_tag="Rv3329"
CDS 3714392..3715708
/codon_start=1
/transl_table=11
/locus_tag="Rv3329"
/product="Probable aminotransferase"
/note="Rv3329, (MTV016.29), len: 438 aa (start uncertain).
Probable aminotransferase, similar to many e.g.
O86744|SC6A9.12 from Streptomyces coelicolor (457
aa),FASTA scores: opt: 2120, E(): 5.1e-125, (70.1%
identity in 438 aa overlap); Q9I6J2|PA0299 from
Pseudomonas aeruginosa (456 aa), FASTA scores: opt: 983,
E(): 5.7e-54, (38.1% identity in 425 aa overlap);
Q53196|Y4UB_RHISN from Rhizobium sp. strain NGR234 plasmid
sym pNGR234a (467 aa),FASTA scores: opt: 971, E():
3.3e-53, (39.25% identity in 438 aa overlap);
P33189|YHXA_BACSU from Bacillus subtilis (450 aa), FASTA
scores: opt: 933, E(): 7.5e-51, (40.25% identity in 435 aa
overlap); etc. Equivalent to AAK47775 from Mycobacterium
tuberculosis strain CDC1551 (466 aa) but shorter 28 aa.
Cofactor: pyridoxal phosphate. Could belong to class-III
of pyridoxal-phosphate-dependent aminotransferases."
/db_xref="EnsemblGenomes-Gn:Rv3329"
/db_xref="EnsemblGenomes-Tr:CCP46150"
/db_xref="GOA:O53379"
/db_xref="InterPro:IPR005814"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:O53379"
/protein_id="CCP46150.1"
/translation="MHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVG
YGRAELAEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPGDLNRVFFTSGGTEAV
ETAWKVAKQYFKLTGKPGKQKVISRSIAYHGTTQGALAITGLPLFKAPFEPLTPGGFR
VPNTNFYRAPLHTDLKEFGRWAADRIAEAIEFEGPDTVAAVFLEPVQNAGGCIPAPPG
YFERVREICDRYDVLLVSDEVICAFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLG
AMIASDRLFEPFNDGETMFAHGYTFGGHPVSAAVGLANLDIFEREGLSDHVKRNSPAL
RATLEKLYDLPIVGDIRGEGYFFGIELVKDQATKQTFTDDERARLLGQVSAALFEAGL
YCRTDDRGDPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL"
gene 3715777..3716994
/gene="dacB1"
/locus_tag="Rv3330"
CDS 3715777..3716994
/codon_start=1
/transl_table=11
/gene="dacB1"
/locus_tag="Rv3330"
/product="Probable penicillin-binding protein DacB1
(D-alanyl-D-alanine carboxypeptidase) (DD-peptidase)
(DD-carboxypeptidase) (PBP) (DD-transpeptidase)
(serine-type D-ala-D-ala carboxypeptidase) (D-amino acid
hydrolase)"
/note="Rv3330, (MTV016.30), len: 405 aa. Probable
dacB1,D-alanyl-D-alanine carboxypeptidase
(penicillin-binding protein), equivalent to Mycobacterium
leprae proteins Q9CCM2|ML0691 putative D-alanyl-D-alanine
carboxypeptidase (411 aa), FASTA scores: opt: 2066, E():
2.5e-102, (77.15% identity in 416 aa overlap);
Q49917|L308_F1_36 (228 aa),FASTA scores: opt: 1241, E():
7.9e-59, (78.9% identity in 232 aa overlap) (note that
this protein corresponds to C-terminal part of the
putative protein encoded by Rv3330,aa 174-405); and
Q49921|PBPC (182 aa), FASTA scores: opt: 736, E():
3.7e-32, (73.95% identity in 169 aa overlap) (note that
this protein corresponds to N-terminal part of the
putative protein encoded by Rv3330, aa 1-158); note
L308_F1_36 (228 aa) and PBPC (182 aa) are two consecutive
Mycobacterium leprae ORFs. Also similar to others e.g.
Q9FC34|SC4G1.16c putative D-alanyl-D-alanine
carboxypeptidase from Streptomyces coelicolor (413
aa),FASTA scores: opt: 572, E(): 3.4e-23, (33.75% identity
in 382 aa overlap); P35150|DACB_BACSU penicillin-binding
protein 5* precursor (D-alanyl-D-alanine carboxypeptidase)
from Bacillus subtilis (382 aa), FASTA scores: opt:
422,E(): 2.8e-15, (31.3% identity in 249 aa overlap);
Q9K8X5|DACB|BH2877 D-alanyl-D-alanine carboxypeptidase
(penicillin-binding protein) from Bacillus halodurans (395
aa), FASTA scores: opt: 421, E(): 3.2e-15, (31.95%
identity in 241 aa overlap); etc. Also similar to
Mycobacterium tuberculosis Q10828|Rv2911|MTCY274.43
probable penicillin-binding protein (belongs to peptidase
family S11; also known as the D-alanyl-D-alanine
carboxypeptidase 1 family) (291 aa), FASTA scores: opt:
746, E(): 1.6e-32,(47.0% identity in 266 aa overlap). Has
hydrophobic stretches at both N- and C-termini. Certainly
membrane-bound protein. Belongs to peptidase family S11;
also known as the D-alanyl-D-alanine carboxypeptidase 1
family. Conserved in M. tuberculosis, M. leprae, M. bovis
and M. avium paratuberculosis; predicted to be essential
for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3330"
/db_xref="EnsemblGenomes-Tr:CCP46151"
/db_xref="GOA:O53380"
/db_xref="InterPro:IPR001967"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR018044"
/db_xref="PDB:4PPR"
/db_xref="UniProtKB/TrEMBL:O53380"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46151.1"
/translation="MAFLRSVSCLAAAVFAVGTGIGLPTAAGEPNAAPAACPYKVSTP
PAVDSSEVPAAGEPPLPLVVPPTPVGGNALGGCGIITAPGSAPAPGDVSAEAWLVADL
DSGAVIAARDPHGRHRPASVIKVLVAMASINTLTLNKSVAGTADDAAVEGTKVGVNTG
GTYTVNQLLHGLLMHSGNDAAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGL
DGPGMSTSAYDIGLFYRYAWQNPVFADIVATRTFDFPGHGDHPGYELENDNQLLYNYP
GALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQAAHLLDYGFNTPA
GTQIGTLIEPDPSLMSTDRNPADRQRVDPQAAARISAADALPVRVGVAVIGALIVFGL
IMVARAMNRRPQH"
gene 3717090..3718598
/gene="sugI"
/locus_tag="Rv3331"
CDS 3717090..3718598
/codon_start=1
/transl_table=11
/gene="sugI"
/locus_tag="Rv3331"
/product="Probable sugar-transport integral membrane
protein SugI"
/note="Rv3331, (MTV016.31), len: 502 aa (start uncertain).
Probable sugI, sugar-transport integral membrane
protein,possibly member of major facilitator superfamily
(MFS),similar to several transporters e.g.
P37021|GALP_ECOLI|B2943 galactose-proton symporter
(galactose transporter) from Escherichia coli strain K12
(464 aa), FASTA scores: opt: 818, E(): 1.8e-39, (31.85%
identity in 446 aa overlap); P96742|YWTG
metabolite-transport-related protein from Bacillus
subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39,
(33.2% identity in 428 aa overlap); AAG58074|GALP (alias
BAB37242|ECS3819) galactose-proton symport of transport
system from Escherichia coli strain O157:H7 EDL933 (464
aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity
in 432 aa overlap); P46333|CSBC_BACSU|SS92BR probable
metabolite transport protein from Bacillus subtilis (461
aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity
in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from
Mycobacterium tuberculosis strain CDC1551 (500 aa) but
with some divergence between residues 229 and 254.
Contains PS00216 Sugar transport proteins signature 1 and
PS00217 Sugar transport proteins signature 2. Belongs to
the sugar transporter family."
/db_xref="EnsemblGenomes-Gn:Rv3331"
/db_xref="EnsemblGenomes-Tr:CCP46152"
/db_xref="GOA:L0TDU1"
/db_xref="InterPro:IPR003663"
/db_xref="InterPro:IPR005828"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:L0TDU1"
/inference="protein motif:PROSITE:PS00217"
/inference="protein motif:PROSITE:PS00216"
/protein_id="CCP46152.1"
/translation="MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQL
TRSGRRALLVGLTAASVGVLYGYDLSAIAGALLSLSEEFELTTREQELLTTTAVLGQI
AGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVPMLVVARLLLGVTIGLSVV
VVPVYVAESAPAAVRGSLVTAYQLATLSGIVVGYLVGYLLAGSHGWRAMFGLAAAPAT
LLLPLLWRMPDTARWYLLKGRIADARSALRRIQPEADIDAELADMAAAVDERGGGIGE
MVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGFAGYFAMLALPAMVQVAG
LAAVCASLFLVDRLGRRPILLSGIATMITADAVLITVFANDSDGGTGLVLGFAGVLLF
IIGFNFGFGSLVWVYAAESFPSRLRSMGSSPMLTSTLTANAIVAAFSLTMLRVLGGAG
VFAVFGTFAVVAFVVVYRFAPETKGRKLEEIRHFWENGGRWPAERSPAADEP"
gene 3718595..3719746
/gene="nagA"
/locus_tag="Rv3332"
CDS 3718595..3719746
/codon_start=1
/transl_table=11
/gene="nagA"
/locus_tag="Rv3332"
/product="Probable N-acetylglucosamine-6-phosphate
deacetylase NagA (GlcNAc 6-P deacetylase)"
/note="Rv3332, (MTV016.32), len: 383 aa. Probable
nagA,N-acetylglucosamine-6-phosphate deacetylase, similar
to many e.g. Q9KXV7|SCD95A.17c putative deacetylase from
Streptomyces coelicolor (381 aa), FASTA scores: opt:
1090,E(): 1.6e-55, (47.8% identity in 385 aa overlap);
Q9PDB4|XF1465 N-acetylglucosamine-6-phosphate deacetylase
from Xylella fastidiosa (386 aa), FASTA scores: opt:
667,E(): 3.5e-31, (38.3% identity in 394 aa overlap);
Q9AAZ9|CC0443 N-acetylglucosamine-6-phosphate deacetylase
from Caulobacter crescentus (378 aa), FASTA scores: opt:
661, E(): 7.5e-31, (38.9% identity in 383 aa overlap);
O34450||NAGA_BACSU N-acetylglucosamine-6-phosphate
deacetylase from Bacillus subtilis (396 aa), FASTA scores:
opt: 571, E(): 1.2e-25, (32.45% identity in 376 aa
overlap); etc. Equivalent to AAK47778 from Mycobacterium
tuberculosis strain CDC1551 (346 aa) but longer 37 aa.
Belongs to the NagA family."
/db_xref="EnsemblGenomes-Gn:Rv3332"
/db_xref="EnsemblGenomes-Tr:CCP46153"
/db_xref="GOA:O53382"
/db_xref="InterPro:IPR003764"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR011059"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/TrEMBL:O53382"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46153.1"
/translation="MTVLGADAVVIDGRICRPGWVHTADGRILSGGAGAPPMPADAEF
PDAIVVPGFVDMHVHGGGGASFADGNAADIARAAEFHLRHGTTTTLASLVTAGPAELL
SAVGALAEATRDGVVAGIHLEGPWLSPARCGAHDHTRMRAPDPAEIESVLAAADGAVR
MVTLAPELPGSDAAIRRFRDAEVVVAVGHTDATYTQTRHAIDLGATVGTHLFNAMPPL
DHRAPGPVLALLCDPRVTVEIIADGVHVHPAVVHAVIEAVGPDRVAVVTDAIAAAGCG
DGAFRLGTMPIEVESSVARVAGASTLAGSTTTMDQLFRTVAGLGSKSDSAGDVALAAA
VQVTSATPARALGLTGVGRLAAGYAANLVVLDRDLRVTAVMVNDDWRVG"
gene complement(3719937..3720782)
/locus_tag="Rv3333c"
CDS complement(3719937..3720782)
/codon_start=1
/transl_table=11
/locus_tag="Rv3333c"
/product="Hypothetical proline rich protein"
/note="Rv3333c, (MTV016.33c), len: 281 aa. Hypothetical
unknown pro-rich protein. Equivalent to AAK47780
hypothetical protein from Mycobacterium tuberculosis
strain CDC1551 (265 aa) but longer 16 aa. Predicted to be
an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3333c"
/db_xref="EnsemblGenomes-Tr:CCP46154"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/TrEMBL:O53383"
/protein_id="CCP46154.1"
/translation="MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALL
EKKEIPAVANVPRVIDAAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTT
TMTRFISAAVEIYCPNHHSKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVS
DMTIMSPGWREPTGAMLASVLGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPP
PRPAPPQQPPPPPPEVEPPAGVPQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGF
IRLAP"
gene 3721257..3721697
/locus_tag="Rv3334"
CDS 3721257..3721697
/codon_start=1
/transl_table=11
/locus_tag="Rv3334"
/product="Probable transcriptional regulatory protein
(probably MerR-family)"
/note="Rv3334, (MTV016.34), len: 146 aa. Probable
transcriptional regulator, similar to many regulatory
proteins (notably mercury resistance operon regulators)
e.g. Q9HXV1|PA3689 probable transcriptional regulator MerR
family from Pseudomonas aeruginosa (156 aa), FASTA scores:
opt: 275, E(): 1.6e-11, (35.95% identity in 139 aa
overlap); Q9AKR6|PBRR lead resistance operon regulator
from Ralstonia metallidurans strain CH34 (plasmid pMOL30)
(145 aa), FASTA scores: opt: 267, E(): 5.2e-11, (35.8%
identity in 134 aa overlap); P95838|MERR mercuric
resistance operon regulator from Synechococcus sp. strain
PCC 7942 (Anacystis nidulans R2) (144 aa), FASTA scores:
opt: 266, E(): 6e-11,(31.35% identity in 118 aa overlap);
P22853|MERR_BACSR mercuric resistance operon regulator
from Bacillus sp. strain RC607 (132 aa), FASTA scores:
opt: 262, E(): 1e-10,(34.6% identity in 130 aa overlap);
etc. Contains probable helix-turn-helix motif at aa 1-22
(Score 1478, +4.22 SD). Seems to belong to the MerR family
of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3334"
/db_xref="EnsemblGenomes-Tr:CCP46155"
/db_xref="GOA:O53384"
/db_xref="InterPro:IPR000551"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR015358"
/db_xref="UniProtKB/TrEMBL:O53384"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46155.1"
/translation="MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIV
DRLRFIHRGQAAGLALQEVRQILAIHDRGEAPCAHVRQLLSTRIDEVRAQIAELIALE
GHLQTLLDHASYGPPTEHDHSTVCWILESDLDEPTAIEVSDIHA"
gene complement(3721731..3722600)
/locus_tag="Rv3335c"
CDS complement(3721731..3722600)
/codon_start=1
/transl_table=11
/locus_tag="Rv3335c"
/product="Probable conserved integral membrane protein"
/note="Rv3335c, (MTV016.35c), len: 289 aa. Probable
conserved integral membrane protein, equivalent to
Q49909|ML0687 putative membrane protein U0308AA from
Mycobacterium leprae (313 aa), FASTA scores: opt:
1299,E(): 8.9e-75, (68.75% identity in 288 aa overlap).
Also similar to other hypothetical bacterial proteins e.g.
BAB37825|ECS4402 from Escherichia coli strain O157:H7
(alias P37642|YHJD_ECOLI|B3522 strain K12) (337 aa), FASTA
scores: opt: 591, E(): 4.2e-30, (35.15% identity in 273 aa
overlap); P45417|YHJD_ERWCH from Erwinia chrysanthemi (328
aa), FASTA scores: opt: 500, E(): 2.2e-24, (34.9% identity
in 275 aa overlap); Q9KZA0|SC5G8.14 putative integral
membrane protein from Streptomyces coelicolor (321
aa),FASTA scores: opt: 321, E(): 4.3e-13, (27.3% identity
in 271 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3335c"
/db_xref="EnsemblGenomes-Tr:CCP46156"
/db_xref="GOA:O53385"
/db_xref="InterPro:IPR005274"
/db_xref="InterPro:IPR017039"
/db_xref="UniProtKB/TrEMBL:O53385"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46156.1"
/translation="MGELAEPGVLDRLRARFGWLDHVVRAFTRFNDRNGSLFAAGLTY
YTIFAIFPLLMVGFGVGGFALSRRPELLTTLEERIRTSVSGAVGQQLVDLMNSAIDAR
ASVGVIGLATAAWVGLGWMWHLREALSQMWAHPVAPAGYLRTKLSDLAAMVGTFVVIV
ATIALTVLGHARPMAAVLRWLEIPQFSVFDEIFRGISVLVSVLVSWVLFTWMIGRLPR
EPVGLVTAARAGLMAAVGFELFKQVGAIYLQIVLRSPAGAVFGPVLGLMVFAFVTAWL
ILFATAWAATASA"
gene complement(3722621..3723631)
/gene="trpS"
/locus_tag="Rv3336c"
CDS complement(3722621..3723631)
/codon_start=1
/transl_table=11
/gene="trpS"
/locus_tag="Rv3336c"
/product="Probable tryptophanyl-tRNA synthetase TrpS
(tryptophan--tRNA ligase) (TRPRS) (tryptophan translase)"
/note="Rv3336c, (MTV016.36c), len: 336 aa. Probable
trpS,tryptophanyl-tRNA synthetase, equivalent to
Q49901|SYW_MYCLE|TRPS|ML0686|L308_C1_147 tryptophanyl-tRNA
synthetase from Mycobacterium leprae (343 aa), FASTA
scores: opt: 1859, E(): 4.8e-107, (83.75% identity in 339
aa overlap). Also similar to many e.g. Q9KZA7|TRPS2 from
Streptomyces coelicolor (339 aa), FASTA scores: opt:
1359,E(): 2.6e-76, (60.3% identity in 335 aa overlap);
Q9EYY6|TRPS from Klebsiella aerogenes (334 aa), FASTA
scores: opt: 1077, E(): 5.5e-59, (52.15% identity in 328
aa overlap); P00954|SYW_ECOLI|TRPS|B3384 from Escherichia
coli strain K12 (334 aa), FASTA scores: opt: 1074, E():
8.3e-59,(51.85% identity in 328 aa overlap); etc. Contains
PS00178 Aminoacyl-transfer RNA synthetases class-I
signature. Belongs to class-I aminoacyl-tRNA synthetase
family."
/db_xref="EnsemblGenomes-Gn:Rv3336c"
/db_xref="EnsemblGenomes-Tr:CCP46157"
/db_xref="GOA:P9WFT3"
/db_xref="InterPro:IPR001412"
/db_xref="InterPro:IPR002305"
/db_xref="InterPro:IPR002306"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR024109"
/db_xref="UniProtKB/Swiss-Prot:P9WFT3"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46157.1"
/translation="MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFF
CVVDLHAITIPQDPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGC
FTGFGQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHL
ELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDD
PALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGD
LKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRAHDVASKTVQRVYDRLGF
LL"
gene 3723656..3724042
/locus_tag="Rv3337"
CDS 3723656..3724042
/codon_start=1
/transl_table=11
/locus_tag="Rv3337"
/product="Conserved hypothetical protein"
/note="Rv3337, (MTV016.37), len: 128 aa. Conserved
hypothetical protein, equivalent to N-terminus of
Q49926|ML0685 TPEA (putative hydrolase) from Mycobacterium
leprae (303 aa), FASTA scores: opt: 362, E():
5.7e-17,(74.3% identity in 70 aa overlap). Also weak
similarity in N-terminus to Q98JT7|BAB49078|MLR1789
probable epoxide hydrolase from Rhizobium loti
(Mesorhizobium loti) (300 aa), FASTA scores: opt: 122,
E(): 0.74, (31.95% identity in 97 aa overlap). Homology
suggests this ORF should be in frame with the following
ORF MTV016.38 but no sequence error could be found. Short
distance to start of trpS suggests region may not be
protein-coding. C-terminus extended since first submission
(+47 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3337"
/db_xref="EnsemblGenomes-Tr:CCP46158"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53387"
/protein_id="CCP46158.1"
/translation="MPSPSTTGHHAACGTGGTGFSVGSMRSPIRVGSGEPVLLLHPFL
MSQTVWEKVAQQLADTGRFEVFAPTMAGHNGGPASGTRFCPRRCWPTTSNASSTNWAG
KPAISSATRWAAGSRSNSNDVAGHAA"
gene 3723904..3724548
/locus_tag="Rv3338"
CDS 3723904..3724548
/codon_start=1
/transl_table=11
/locus_tag="Rv3338"
/product="Conserved hypothetical protein"
/note="Rv3338, (MTV016.38), len: 214 aa. Hypothetical
protein, equivalent to C-termini of Q49926|ML0685 TPEA
(putative hydrolase) from Mycobacterium leprae (303
aa),FASTA scores: opt: 984, E(): 2.6e-56, (65.4% identity
in 214 aa overlap); and O32873|MLCB1779.02 hypothetical
31.8 KDA protein (similar to alpha/beta hydrolase fold)
from Mycobacterium leprae (292 aa), FASTA scores: opt:
984, E(): 2.5e-56, (65.4% identity in 214 aa overlap).
Also similar to C-termini of several hypothetical proteins
(generally hydrolases) e.g. Q9K3H6|2SCG18.11 putative
hydrolase from Streptomyces coelicolor (316 aa), FASTA
scores: opt: 213,E(): 1.4e-06, (29.75% identity in 185 aa
overlap). Homology suggests that this ORF should be in
frame with the previous ORF MTV016.37 but no sequence
error could be found."
/db_xref="EnsemblGenomes-Gn:Rv3338"
/db_xref="EnsemblGenomes-Tr:CCP46159"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O53388"
/protein_id="CCP46159.1"
/translation="MSSAVLADHVERQLDELGWETSHIVGNSLGGWVAFELERRGRAR
SVTGIAPAGGWTRWSPVKFEVIAKFIAGAPILAVAHILGQRALRLPFSRLLATLPISA
TPDGVSERELSGIIDDAAHCPAYFQLLVKALVLPGLQELEHTAVPSHVVLCEQDRVVP
PSRFSRHFTDSLPAGHRLTVLDGVGHVPMFEAPGRITELITSFIEECCPHVRAS"
gene complement(3724615..3725844)
/gene="icd1"
/locus_tag="Rv3339c"
CDS complement(3724615..3725844)
/codon_start=1
/transl_table=11
/gene="icd1"
/locus_tag="Rv3339c"
/product="Probable isocitrate dehydrogenase [NADP] Icd1
(oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH)
(IDP)"
/note="Rv3339c, (MTV016.39c), len: 409 aa. Probable
icd1,isocitrate dehydrogenase NADP-dependent, highly
similar to many e.g. Q9A5C8|CC2522 from Caulobacter
crescentus (403 aa), FASTA scores: opt: 1972, E():
4.6e-115, (72.45% identity in 403 aa overlap);
AAF73472|ICD from Rhizobium meliloti (404 aa), FASTA
scores: opt: 1968, E(): 8.1e-115,(73.2% identity in 403 aa
overlap); P50215|IDH_SPHYA from Sphingomonas yanoikuyae
(406 aa), FASTA scores: opt: 1964,E(): 1.4e-114, (71.45%
identity in 403 aa overlap); etc. Contains PS00470
Isocitrate and isopropylmalate dehydrogenases signature.
Belongs to the isocitrate and isopropylmalate
dehydrogenases family. Note that in H37Rv,Rv0066c is named
icd2 and Rv3339c is icd1 while in CDC1551 and Erdman
strains, Rv0066c is icd1 and Rv3339c is icd2."
/db_xref="EnsemblGenomes-Gn:Rv3339c"
/db_xref="EnsemblGenomes-Tr:CCP46160"
/db_xref="GOA:P9WKL1"
/db_xref="InterPro:IPR004790"
/db_xref="InterPro:IPR019818"
/db_xref="InterPro:IPR024084"
/db_xref="PDB:4HCX"
/db_xref="UniProtKB/Swiss-Prot:P9WKL1"
/inference="protein motif:PROSITE:PS00470"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46160.1"
/translation="MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDY
YDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTI
RNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFT
PADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTI
LKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYD
GDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIA
SIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNS
EEFLDAIADNLEKELAN"
gene 3726127..3727476
/gene="metC"
/locus_tag="Rv3340"
CDS 3726127..3727476
/codon_start=1
/transl_table=11
/gene="metC"
/locus_tag="Rv3340"
/product="Probable O-acetylhomoserine sulfhydrylase MetC
(homocysteine synthase) (O-acetylhomoserine (thiol)-lyase)
(OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase)"
/note="Rv3340, (MTV016.40), len: 449 aa. Probable
metC,O-acetyl-L-homoserine sulfhydrylase, highly similar
to many e.g. Q9K9P2|BH2603 O-acetylhomoserine
sulfhydrylase from Bacillus halodurans (430 aa), FASTA
scores: opt: 1716, E(): 3.3e-97, (60.45% identity in 425
aa overlap); Q9HUE4|METY|PA5025 homocysteine synthase from
Pseudomonas aeruginosa (425 aa), FASTA scores: opt: 1517,
E(): 4.4e-85,(56.95% identity in 425 aa overlap);
Q9WZY4|TM0882 O-acetylhomoserine sulfhydrylase from
Thermotoga maritima (430 aa), FASTA scores: opt: 1488,
E(): 2.6e-83, (55.75% identity in 418 aa overlap);
BAB54344|MLR8465 O-acetylhomoserine sulfhydrylase from
Rhizobium loti (Mesorhizobium loti) (426 aa), FASTA
scores: opt: 1445,E(): 1.1e-80, (53.2% identity in 419 aa
overlap); P50125|CYSD_EMENI O-acetylhomoserine
(thiol)-lyase from Emericella nidulans (Aspergillus
nidulans) (437 aa), FASTA scores: opt: 1442, E(): 1.7e-80,
(53.7% identity in 430 aa overlap); etc. Contains PS00868
Cys/Met metabolism enzymes pyridoxal-phosphate attachment
site. Cofactor: pyridoxal phosphate. Belongs to the
trans-sulfuration enzymes family."
/db_xref="EnsemblGenomes-Gn:Rv3340"
/db_xref="EnsemblGenomes-Tr:CCP46161"
/db_xref="GOA:O53390"
/db_xref="InterPro:IPR000277"
/db_xref="InterPro:IPR006235"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/TrEMBL:O53390"
/inference="protein motif:PROSITE:PS00868"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46161.1"
/translation="MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATT
SYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAET
FAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNT
KAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSA
TKYLGGHGAAIAGVIVDGGNFDWTQGRFPGFTTPDPSYHGVVFAELGPPAFALKARVQ
LLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPS
SPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPAS
TTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFSADPQSVAAF"
gene 3727488..3728627
/gene="metA"
/locus_tag="Rv3341"
CDS 3727488..3728627
/codon_start=1
/transl_table=11
/gene="metA"
/locus_tag="Rv3341"
/product="Probable homoserine O-acetyltransferase MetA
(homoserine O-trans-acetylase) (homoserine transacetylase)
(HTA)"
/note="Rv3341, (MTV016.41), len: 379 aa. Probable
metA,homoserine o-acetyltransferase (see citation
below),equivalent to
O32874|METX_MYCLE|meta|ML0682|MLCB1779.11 homoserine
O-acetyltransferase from Mycobacterium leprae (382 aa),
FASTA scores: opt: 2263, E(): 9.2e-129, (85.0% identity in
380 aa overlap). Also highly similar to many e.g.
O68640|METX_CORGL|meta from Corynebacterium glutamicum
(Brevibacterium flavum) (379 aa), FASTA scores: opt:
1135,E(): 5.9e-61, (48.5% identity in 371 aa overlap);
Q9AAS1|CC0525 from Caulobacter crescentus (382 aa), FASTA
scores: opt: 860, E(): 2e-44, (40.5% identity in 363 aa
overlap); P94891|METX_LEPME from Leptospira meyeri (379
aa), FASTA scores: opt: 787, E(): 4.9e-40, (38.2% identity
in 385 aa overlap); etc. Belongs to the ab hydrolase
family, HTA subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3341"
/db_xref="EnsemblGenomes-Tr:CCP46162"
/db_xref="GOA:P9WJY9"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR008220"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WJY9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46162.1"
/translation="MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWG
KLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNV
LGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGG
ARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRA
PDAGLRLARRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSR
FDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADL
LPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR"
gene 3728624..3729355
/locus_tag="Rv3342"
CDS 3728624..3729355
/codon_start=1
/transl_table=11
/locus_tag="Rv3342"
/product="Possible methyltransferase (methylase)"
/note="Rv3342, (MTV016.42), len: 243 aa. Possible
methyltransferase, similar to various proteins e.g.
Q9I5X8|PA0558 hypothetical protein from Pseudomonas
aeruginosa (255 aa), FASTA scores: opt: 496, E():
4.4e-24,(39.85% identity in 236 aa overlap);
Q9XBC9|CZA382.22c putative rRNA methylase from
Amycolatopsis orientalis (259 aa), FASTA scores: opt: 473,
E(): 1.2e-22, (42.45% identity in 245 aa overlap);
Q9UTA8|SPAC25B8.10 putative methyltransferase from
Schizosaccharomyces pombe (Fission yeast) (256 aa), FASTA
scores: opt: 470, E(): 1.9e-22,(35.7% identity in 238 aa
overlap); and Q9UTA9|SPAC25B8.09 putative
methyltransferase from Schizosaccharomyces pombe (Fission
yeast) (251 aa), FASTA scores: opt: 418, E(): 3.4e-19,
(31.2% identity in 237 aa overlap); etc. Start uncertain.
Belongs to the methyltransferase superfamily."
/db_xref="EnsemblGenomes-Gn:Rv3342"
/db_xref="EnsemblGenomes-Tr:CCP46163"
/db_xref="GOA:P9WK01"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WK01"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46163.1"
/translation="MTCSRRDMSLSFGSAVGAYERGRPSYPPEAIDWLLPAAARRVLD
LGAGTGKLTTRLVERGLDVVAVDPIPEMLDVLRAALPQTVALLGTAEEIPLDDNSVDA
VLVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRDERLGWVRELGEIIGRDGDPVR
DRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASRSYCITSPAQVRTKTLDRVRQLLA
THPALANSNGLALPYVTVCVRATLA"
gene complement(3729364..3736935)
/gene="PPE54"
/locus_tag="Rv3343c"
CDS complement(3729364..3736935)
/codon_start=1
/transl_table=11
/gene="PPE54"
/locus_tag="Rv3343c"
/product="PPE family protein PPE54"
/note="Rv3343c, (MTV016.43c), len: 2523 aa. PPE54, Member
of the Mycobacterium tuberculosis PPE family, MPTR
subgroup of Gly-, Asn-rich proteins. Most similar to
O50379|Rv3350c|MTV004.07c|MTV004_5 from Mycobacterium
tuberculosis strain H37Rv (3716 aa), FASTA scores: opt:
4672, E(): 4e-211, (44.2% identity in 3174 aa overlap);
and also similar to MTV004_3, MTCY63_9,
MTY13E10_17,MTY13E10_16, MTCY180_1, MTV050_1, MTCY3C7_23,
MTV014_3,MTCY63_10; etc."
/db_xref="EnsemblGenomes-Gn:Rv3343c"
/db_xref="EnsemblGenomes-Tr:CCP46164"
/db_xref="GOA:Q6MWY2"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:Q6MWY2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46164.1"
/translation="MSFVVMPPEINSLLIYTGAGPGPLLAAAAAWDELAAELGSAAAA
FGSVTSGLVGGIWQGPSSVAMAAAAAPYAGWLSAAAASAESAAGQARAVVGVFEAALA
ETVDPFVIAANRSRLVSLALSNLFGQNTPAIAAAEFDYELMWAQDVAAMLGYHTGASA
AAEALAPFGSPLASLAAAAEPAKSLAVNLGLANVGLFNAGSGNVGSYNVGAGNVGSYN
VGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNI
GFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSG
SYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSFNAGEANTGGFNPGSVNTGWLN
TGDINTGVANSGDVNTGAFISGNYSNGVLWRGDYQGLLGFSSGANVLPVIPLSLDING
GVGAITIEPIHILPDIPININETLYLGPLVVPPINVPAISLGVGIPNISIGPIKINPI
TLWPAQNFNQTITLAWPVSSITIPQIQQVALSPSPIPTTLIGPIHINTGFSIPVTFSY
STPALTLFPVGLSIPTGGPLTLTLGVTAGTEAFTIPGFSIPEQPLPLAINVIGHINAL
STPAITIDNIPLNLHAIGGVGPVDIVGGNVPASPGFGNSTTAPSSGFFNTGAGGVSGF
GNVGAHTSGWFNQSTQAMQVLPGTVSGYFNSGTLMSGIGNVGTQLSGMLSGGALGGNN
FGLGNIGFDNVGFGNAGSSNFGLANMGIGNIGLANTGNGNIGIGLSGDNLTGFGGFNS
GSENVGLFNSGTGNVGFFNSGTGNLGVFNSGSHNTGFFLTGNNINVLAPFTPGTLFTI
SEIPIDLQVIGGIGPIHVQPIDIPAFDIQITGGFIGIREFTLPEITIPAIPIHVTGTV
GLEGFHVNPAFVLFGQTAMAEITADPVVLPDPFITIDHYGPPLGPPGAKFPSGSFYLS
ISDLQINGPIIGSYGGPGTIPGPFGATFNLSTSSLALFPAGLTVPDQTPVTVNLTGGL
DSITLFPGGLAFPENPVVSLTNFSVGTGGFTVFPQGFTVDRIPVDLHTTLSIGPFPFR
WDYIPPTPANGPIPAVPGGFGLTSGLFPFHFTLNGGIGPISIPTTTVVDALNPLLTVT
GNLEVGPFTVPDIPIPAINFGLDGNVNVSFNAPATTLLSGLGITGSIDISGIQITNIQ
TQPAQLFMSVGQTLFLFDFRDGIELNPIVIPGSSIPITMAGLSIPLPTVSESIPLNFS
FGSPASTVKSMILHEILPIDVSINLEDAVFIPATVLPAIPLNVDVTIPVGPINIPIIT
EPGSGNSTTTTSDPFSGLAVPGLGVGLLGLFDGSIANNLISGFNSAVGIVGPNVGLSN
LGGGNVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGFGNVGLANSGLTPGLM
GLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVG
LFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYN
TGSFNAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGD
YQGLLGFSYRPAVLPQTPFLDLTLTGGLGSVVIPAIDIPAIRPEFSANVAIDSFTVPS
IPIPQIDLAATTVSVGLGPITVPHLDIPRVPVTLNYLFGSQPGGPLKIGPITGLFNTP
IGLTPLALSQIVIGASSSQGTITAFLANLPFSTPVVTIDEIPLLASITGHSEPVDIFP
GGLTIPAMNPLSINLSGGTGAVTIPAITIGEIPFDLVAHSTLGPVHILIDLPAVPGFG
NTTGAPSSGFFNSGAGGVSGFGNVGAMVSGGWNQAPSALLGGGSGVFNAGTLHSGVLN
FGSGMSGLFNTSVLGLGAPALVSGLGSVGQQLSGLLASGTALHQGLVLNFGLADVGLG
NVGLGNVGDFNLGAGNVGGFNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGN
IGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNS
GTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIASTGLFNAGGFNTGVVNAGSYNTGSF
NAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGAFWRGDYQGL
LGFSYTSTIIPEFTVANIHASGGAGPIIVPSIQFPAIPLDLSATGHIGGFTIPPVSIS
PITVRIDPVFDLGPITVQDITIPALGLDPATGVTVGPIFSSGSIIDPFSLTLLGFINV
NVPAIQTAPSEILPFTVLLSSLGVTHLTPEITIPGFHIPVDPIHVELPLSVTIGPFVS
PEITIPQLPLGLALSGATPAFAFPLEITIDRIPVVLDVNALLGPINAGLVIPPVPGFG
NTTAVPSSGFFNIGGGGGLSGFHNLGAGMSGVLNAISDPLLGSASGFANFGTQLSGIL
NRGADISGVYNTGALGLITSALVSGFGNVGQQLAGLIYTGTGP"
gene complement(3736984..>3738438)
/gene="PE_PGRS49"
/locus_tag="Rv3344c"
CDS complement(3736984..>3738438)
/codon_start=1
/transl_table=11
/gene="PE_PGRS49"
/locus_tag="Rv3344c"
/product="PE-PGRS family protein PE_PGRS49"
/note="Rv3344c, (MTV016.44c), len: 484 aa.
PE_PGRS49,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-, ala-rich proteins (see
Brennan and Delogu, 2002). Appears to be a gene fragment,
should be in-frame with following ORF, MTV016.45c,
frameshift required around 49595 but could not be found on
checking BAC and cosmid clones. Similar to many from
Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g.
O53557|Rv3512|MTV023.19 (1079 aa), FASTA scores: opt:
1595,E(): 1.8e-54, (52.0% identity in 544 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3344c"
/db_xref="EnsemblGenomes-Tr:CCP46165"
/db_xref="UniProtKB/TrEMBL:L0TFC2"
/protein_id="CCP46165.1"
/translation="AQASPAAHGGSGGAGGNGGAGSAGNGGAGGAGGNGGAGGNGGGG
DAGNAGSGGNGGKGGDGVGPGSTGGAGGKGGAGANGGSSNGNARGGNAGNGGHGGAGG
SGDTGGAGGAGGQGGFGGTGGSGSGIGGGAGGNGGNGGAGGTGVVLGGKGGDGGNGDH
GGPATNPGSGSRGGAGGSGGNGGAGGNATGSGGKGGAGGNGGDGSFGATSGPASIGVT
GAPGGNGGKGGAGGSNPNGSGGDGGKGGNGGAGGNGGSIGANSGIVGGSGGAGGAGGA
GGNGSLSSGEGGKGGDGGHGGDGVGGNSSVTQGGSGGGGGAGGAGGSGFFGGKGGFGG
DGGQGGPNGGGTVGTVAGGGGNGGVGGRGGDGVFAGAGGQGGLGGQGGNGGGSTGGNG
GLGGAGGGGGNAPDGGFGGNGGKGGQGGIGGGTQSATGLGGDGGDGGDGGNGGNSGAK
AGGAGGKGQAGQPNSGTEPGFGGDGGLGGAGATP"
gene complement(3738158..3742774)
/gene="PE_PGRS50"
/locus_tag="Rv3345c"
CDS complement(3738158..3742774)
/codon_start=1
/transl_table=11
/gene="PE_PGRS50"
/locus_tag="Rv3345c"
/product="PE-PGRS family protein PE_PGRS50"
/note="Rv3345c, (MTV004.01c-MTV016.45c), len: 1538 aa.
PE_PGRS50, Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan
and Delogu, 2002). Similar to AAK47791 from strain CDC1551
but with some big gaps (after residues 501 and 1419; and
for AAK47791 after residue 991). Similar to many from
Mycobacterium tuberculosis strains H37Rv and CDC1551."
/db_xref="EnsemblGenomes-Gn:Rv3345c"
/db_xref="EnsemblGenomes-Tr:CCP46166"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MWY0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46166.1"
/translation="MVMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAA
GDEVSAAIAALFGTHAQEYQALSARVATFHEQFVRSLTAAGSAYATAEAANASPLQAL
EQQVLGAINAPTQLWLGRPLIGDGVHGAPGTGQPGGAGGLLWGNGGNGGSGAAGQVGG
PGGAAGLFGNGGSGGSGGAGAAGGVGGSGGWLNGNGGAGGAGGTGANGGAGGNAWLFG
AGGSGGAGTNGGVGGSGGFVYGNGGAGGIGGIGGIGGNGGDAGLFGNGGAGGAGAAGL
PGAAGLNGGDGSDGGNGGTGGNGGRGGLLVGNGGAGGAGGVGGDGGKGGAGDPSFAVN
NGAGGNGGHGGNPGVGGAGGAGGLLAGAHGAAGATPTSGGNGGDGGIGATANSPLQAG
GAGGNGGHGGLVGNGGTGGAGGAGHAGSTGATGTALQPTGGNGTNGGAGGHGGNGGNG
GAQHGDGGVGGKGGAGGSGGAGGNGFDAATLGSPGADGGMGGNGGKGGDGGKAGDGGA
GAAGDVTLAVNQGAGGDGGNGGEVGVGGKGGAGGVSANPALNGSAGANGTAPTSGGNG
GNGGAGATPTVAGENGGAGGNGGHGGSVGNGGAGGAGGNGVAGTGLALNGGNGGNGGI
GGNGGSAAGTGGDGGKGGNGGAGANGQDFSASANGANGGQGGNGGNGGIGGKGGDAFA
TFAKAGNGGAGGNGGNVGVAGQGGAGGKGAIPAMKGATGADGTAPTSGGDGGNGGNGA
SPTVAGGNGGDGGKGGSGGNVGNGGNGGAGGNGAAGQAGTPGPTSGDSGTSGTDGGAG
GNGGAGGAGGTLAGHGGNGGKGGNGGQGGIGGAGERGADGAGPNANGANGENGGSGGN
GGDGGAGGNGGAGGKAQAAGYTDGATGTGGDGGNGGDGGKAGDGGAGENGLNSGAMLP
GGGTVGNPGTGGNGGNGGNAGVGGTGGKAGTGSLTGLDGTDGITPNGGNGGNGGNGGK
GGTAGNGSGAAGGNGGNGGSGLNGGDAGNGGNGGGALNQAGFFGTGGKGGNGGNGGAG
MINGGLGGFGGAGGGGAVDVAATTGGAGGNGGAGGFASTGLGGPGGAGGPGGAGDFAS
GVGGVGGAGGDGGAGGVGGFGGQGGIGGEGRTGGNGGSGGDGGGGISLGGNGGLGGNG
GVSETGFGGAGGNGGYGGPGGPEGNGGLGGNGGAGGNGGVSTTGGDGGAGGKGGNGGD
GGNVGLGGDAGSGGAGGNGGIGTDAGGAGGAGGAGGNGGSSKSTTTGNAGSGGAGGNG
GTGLNGAGGAGGAGGNAGVAGVSFGNAVGGDGGNGGNGGHGGDGTTGGAGGKGGNGSS
GAASGSGVVNVTAGHGGNGGNGGNGGNGSAGAGGQGGAGGSAGNGGHGGGATGGDGGN
GGNGGNSGNSTGVAGLAGGAAGAGGNGGGTSSAAGHGGSGGSGGSGTTGGAGAAGGNG
GAGAGGGSLSTGQSGGPRRQRWCRWQRRRWLGRQRRRRWCRWQRRCRRQRWRWRCRQR
RLRRQWRQGRRRCRPWLHRRRGRQGRRWRQRRFQQRQRSRWQRR"
gene complement(3743198..3743455)
/locus_tag="Rv3346c"
CDS complement(3743198..3743455)
/codon_start=1
/transl_table=11
/locus_tag="Rv3346c"
/product="Conserved transmembrane protein"
/note="Rv3346c, (MTV004.02c), len: 85 aa. Conserved
transmembrane protein, highly similar to mycobacterium
hypothetical proteins O50384|Rv3355c|MTV004.12c from
strain H37Rv (97 aa), FASTA scores: opt: 413, E():
4.6e-23,(85.55% identity in 97 aa overlap);
O32878|MLCB1779.16c|ML0675 from Mycobacterium leprae (91
aa), FASTA scores: opt: 349, E(): 1.7e-18, (67.35%
identity in 95 aa overlap). Contains possible membrane
spanning regions."
/db_xref="EnsemblGenomes-Gn:Rv3346c"
/db_xref="EnsemblGenomes-Tr:CCP46167"
/db_xref="GOA:O50377"
/db_xref="InterPro:IPR021385"
/db_xref="UniProtKB/TrEMBL:O50377"
/protein_id="CCP46167.1"
/translation="MTVRAVLRRTVGAQWPILAGVNFWRRGALLIGIGVGVAAVLRLV
LSEERAGLLVVRSKGIDFVTTVTVAAAMVYIASTIDPLGTG"
repeat_region 3743198..3743404
/note="207 bp imperfect direct repeat 1, 199/207 bp
identical to second copy at 3769514..3769720"
repeat_region 3743402..3743510
/note="109 bp imperfect direct repeat 1, 95/109 bp
identical to second copy at 3769754..3769862"
repeat_region 3743508..3743605
/note="98 bp imperfect direct repeat 1, 82/98 bp identical
to the second copy at 3770994..3771091"
gene complement(3743711..3753184)
/gene="PPE55"
/locus_tag="Rv3347c"
CDS complement(3743711..3753184)
/codon_start=1
/transl_table=11
/gene="PPE55"
/locus_tag="Rv3347c"
/product="PPE family protein PPE55"
/note="Rv3347c, (MTV004.03c), len: 3157 aa. PPE55, Member
of the Mycobacterium tuberculosis PPE family, Gly-,
Ala-,Asn-rich protein. Similar to many from Mycobacterium
tuberculosis strains H37Rv and CDC1551, e.g.
O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt:
6497, E(): 0, (61.65% identity in 3756 aa overlap); and
other upstream ORFs MTV004_5, MTY13E10_15,
MTCY28_16,MTCY63_9, MTY13E10_17, MTCY180_1; etc. Predicted
possible vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3347c"
/db_xref="EnsemblGenomes-Tr:CCP46168"
/db_xref="GOA:Q6MWX9"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q6MWX9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46168.1"
/translation="MNFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVS
FGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAQAVAVAGQARAAVAAFEAALA
ATVDPAAVAVNRMAMRALAMSNLLGQNAAAIAAVEAEYELMWAADVAAMAGYHSGASA
AAAALPAFSPPAQALGGGVGAFLNALFAGPAKMLRLNAGLGNVGNYNVGLGNVGIFNL
GAANVGAQNLGAANAGSGNFGFGNIGNANFGFGNSGLGLPPGMGNIGLGNAGSSNYGL
ANLGVGNIGFANTGSNNIGIGLTGDNLTGIGGLNSGTGNLGLFNSGTGNIGFFNSGTG
NFGVFNSGSYNTGVGNAGTASTGLFNVGGFNTGVANVGSYNTGSFNAGNTNTGGFNPG
NVNTGWLNTGNTNTGIANSGNVNTGAFISGNFSNGVLWRGDYEGLWGLSGGSTIPAIP
IGLELNGGVGPITVLPIQILPTIPLNIHQTFSLGPLVVPDIVIPAFGGGTAIPISVGP
ITISPITLFPAQNFNTTFPVGPFFGLGVVNISGIEIKDLAGNVTLQLGNLNIDTRINQ
SFPVTVNWSTPAVTIFPNGISIPNNPLALLASASIGTLGFTIPGFTIPAAPLPLTIDI
DGQIDGFSTPPITIDRIPLNLGASVTVGPILINGVNIPATPGFGNTTTAPSSGFFNSG
DGGVSGFGNFGAGSSGWWNQAQTEVAGAGSGFANFGSLGSGVLNFGSGVSGLYNTGGL
PPGTPAVVSGIGNVGEQLSGLSSAGTALNQSLIINLGLADVGSVNVGFGNVGDFNLGA
ANIGDLNVGLGNVGGGNVGFGNIGDANFGLGNAGLAAGLAGVGNIGLGNAGSGNVGFG
NMGVGNIGFGNTGTNNLGIGLTGDNQTGIGGLNSGAGNIGLFNSGTGNVGLFNSGTGN
FGLFNSGSFNTGIGNGGTGSTGLFNAGNFNTGVANPGSYNTGSFNVGDTNTGGFNPGS
INTGWFNTGNANTGVANSGNVDTGALMSGNFSNGILWRGNFEGLFGLNVGITIPEFPI
HWTSTGGIGPIIIPDTTILPPIHLGLTGQANYGFAVPDIPIPAIHIDFDGAADAGFTA
PATTLLSALGITGQFRFGPITVSNVQLNPFNVNLKLQFLHDAFPNEFPDPTISVQIQV
AIPLTSATLGGLALPLQQTIDAIELPAISFSQSIPIDIPPIDIPASTINGISMSEVVP
IDVSVDIPAVTITGTRIDPIPLNFDVLSSAGPINISIIDIPALPGFGNSTELPSSGFF
NTGGGGGSGIANFGAGVSGLLNQASSPMVGTLSGLGNAGSLASGVLNSGVDISGMFNV
STLGSAPAVISGFGNLGNHVSGVSIDGLLAMLTSGGSGGSGQPSIIDAAIAELRHLNP
LNIVNLGNVGSYNLGFANVGDVNLGAGNLGNLNLGGGNLGGQNLGLGNLGDGNVGFGN
LGHGNVGFGNSGLGALPGIGNIGLGNAGSNNVGFGNMGLGNIGFGNTGTNNLGIGLTG
DNQTGFGGLNSGAGNLGLFNSGTGNIGFFNTGTGNWGLFNSGSYNTGIGNSGTGSTGL
FNAGSFNTGLANAGSYNTGSLNAGNTNTGGFNPGNVNTGWFNAGHTNTGGFNTGNVNT
GAFNSGSFNNGALWTGDHHGLVGFSYSIEITGSTLVDINETLNLGPVHIDQIDIPGMS
LFDIHELVNIGPFRIEPIDVPAVVLDIHETMVIPPIVFLPSMTIGGQTYTIPLDTPPA
PAPPPFRLPLLFVNALGDNWIVGASNSTGMSGGFVTAPTQGILIHTGPSSATTGSLAL
TLPTVTIPTITTSPIPLKIDVSGGLPAFTLFPGGLNIPQNAIPLTIDASGVLDPITIF
PGGFTIDPLPLSLALNISVPDSSVPIIIVPPTPGFGNATATPSSGFFNSGAGGVSGFG
NFGAGSSGWWNQAHAALAGAGSGVLNVGTLNSGVLNVGSGISGLYNTAIVGLGTPALV
SGAGNVGQQLSGVLAAGTALTQSPIINLGLADVGNYNLGLGNVGDFNLGAANLGDLNL
GLGNIGNANVGFGNIGHGNVGFGNSGLGAALGIGNIGLGNAGSTNVGLANMGVGNIGF
ANTGTNNLGIGLTGDNQTGIGGLNSGAGNIGLFNSGTGNIGFFNSGTGNWGLFNSGSF
NTGIGNSGTGSTGLFNAGGFTTGLANAGSYNTGSFNVGDTNTGGFNPGSINTGWFNTG
NANTGIANSGNVDTGALMSGNFSNGILWRGNYEGLFSYSYSLDVPRITILDAHFTGAF
GPVVVPPIPVLAINAHLTGNAAMGAFTIPQIDIPALNPNVTGSVGFGPIAVPSVTIPA
LTAARAVLDMAASVGATSEIEPFIVWTSSGAIGPTWYSVGRIYNAGDLFVGGNIISGI
PTLSTTGPVHAVFNAASQAFNTPALNIHQIPLGFQVPGSIDAITLFPGGLTFPANSLL
NLDVFVGTPGATIPAITFPEIPANADGELYVIAGDIPLINIPPTPGIGNTTTVPSSGF
FNTGAGGGSGFGNFGANMSGWWNQAHTALAGAGSGIANVGTLHSGVLNLGSGLSGIYN
TSTLPLGTPALVSGLGNVGDHLSGLLASNVGQNPITIVNIGLANVGNGNVGLGNIGNL
NLGAANIGDVNLGFGNIGDVNLGFGNIGGGNVGFGNIGDANFGFGNSGLAAGLAGMGN
IGLGNAGSGNVGWANMGLGNIGFGNTGTNNLGIGLTGDNQSGIGGLNSGTGNIGLFNS
GTGNIGFFNSGTANFGLFNSGSYNTGIGNSGVASTGLVNAGGFNTGVANAGSYNTGSF
NAGDTNTGGFNPGSTNTGWFNTGNANTGVANAGNVNTGALITGNFSNGILWRGNYEGL
AGFSFGYPIPLFPAVGADVTGDIGPATIIPPIHIPSIPLGFAAIGHIGPISIPNIAIP
SIHLGIDPTFDVGPITVDPITLTIPGLSLDAAVSEIRMTSGSSSGFKVRPSFSFFAVG
PDGMPGGEVSILQPFTVAPINLNPTTLHFPGFTIPTGPIHIGLPLSLTIPGFTIPGGT
LIPQLPLGLGLSGGTPPFDLPTVVIDRIPVELHASTTIGPVSLPIFGFGGAPGFGNDT
TAPSSGFFNTGGGGGSGFSNSGSGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGA
GISGVYNTGTLGLVTSAFVSGFMNVGQQLSGLLFAGTGP"
gene 3753765..3754256
/locus_tag="Rv3348"
CDS 3753765..3754256
/codon_start=1
/transl_table=11
/locus_tag="Rv3348"
/product="Probable transposase"
/note="Rv3348, (MTV004.04), len: 163 aa. Probable
transposase, partially similar to several insertion
elements e.g. P19834|YI11_STRCL insertion element IS116
hypothetical 44.8 KDA protein (similar to IS900 of
Mycobacterium paratuberculosis) from Streptomyces
clavuligerus (399 aa), FASTA scores: opt: 146, E():
0.016,(29.1% identity in 158 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3348"
/db_xref="EnsemblGenomes-Tr:CCP46169"
/db_xref="GOA:P96234"
/db_xref="InterPro:IPR002525"
/db_xref="UniProtKB/TrEMBL:P96234"
/protein_id="CCP46169.1"
/translation="MTAENPGRSRRTLVGIDAAITACHHIAIRDDVGARSIRFSVEPT
LAGLRTLTDKLSGYDDIDATVEPTSMTWLPLTIAVENAGDTMHMAGARHCARLRGAIV
GKSKSDVIDAEVLTRASEVFDLTPLTLPTPAQLALRRSVIRRAGAVIDANRSWRRLMS
LAR"
mobile_element 3753765..3754253
/mobile_element_type="insertion sequence:IS1608'"
/locus_tag="Rv3348"
/note="IS1608', len: 489 nt. Insertion sequence IS1608'."
gene complement(3754293..3755033)
/locus_tag="Rv3349c"
CDS complement(3754293..3755033)
/codon_start=1
/transl_table=11
/locus_tag="Rv3349c"
/product="Probable transposase"
/note="Rv3349c, (MTV004.05c), len: 246 aa. Probable
transposase pseudogene fragment, similar to part of
Q50911|U10634 IS204 putative transposase from nocardia
asteroides (377 aa), FASTA scores: opt: 288, E():
8.3e-11,(48.5% identity in 97 aa overlap); and others."
/db_xref="EnsemblGenomes-Gn:Rv3349c"
/db_xref="EnsemblGenomes-Tr:CCP46170"
/db_xref="InterPro:IPR002560"
/db_xref="UniProtKB/TrEMBL:V5QQS8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46170.1"
/translation="MAIDPAAAYASAIRTPGLLPNAKLVVDHFHVTTLANDALTAVRR
RVTWAFHDRRGRKIDPQWANRRRLLTARERLSDKSFAKMRNRINAVDPRAQILSAWIA
KEELRTLLSTVRTGGDPHLARHHLHRFLPGASTRRSPNCSPWPPPLTSHPRSTPSWSP
ASPTRASVVGEVAEMLGDIDGQCVQVEVPVPERGPAGCGGLDGLGRAGVSATPRVCAA
MTAVNVAGRCAGQQADVGPTPQHRCRGR"
mobile_element complement(3754296..3755033)
/mobile_element_type="insertion sequence:IS1561'"
/locus_tag="Rv3349c"
/note="IS1561', len: 738 nt. Insertion sequence IS1561'."
gene complement(3755952..3767102)
/gene="PPE56"
/locus_tag="Rv3350c"
CDS complement(3755952..3767102)
/codon_start=1
/transl_table=11
/gene="PPE56"
/locus_tag="Rv3350c"
/product="PPE family protein PPE56"
/note="Rv3350c, (MTV004.07c), len: 3716 aa. PPE56, Member
of the Mycobacterium tuberculosis PPE family of Gly-,
Ala-,Asn-rich proteins, similar to many Mycobacterium
tuberculosis proteins from strains H37Rv and CDC1551, e.g.
O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt:
6497, E(): 0, (61.65% identity in 3756 aa overlap);
MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10,
MTCY180_1,MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc."
/db_xref="EnsemblGenomes-Gn:Rv3350c"
/db_xref="EnsemblGenomes-Tr:CCP46171"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q6MWX8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46171.1"
/translation="MEFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVS
FGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAAAEAVAGQARVVVGVFEAALA
ATVDPALVAANRARLVALAVSNLLGQNTPAIAAAEAEYELMWAADVAAMAGYHSGASA
AAAALPAFSPPAQALGGGVGAFLTALFASPAKALSLNAGLGNVGNYNVGLGNVGVFNL
GAGNVGGQNLGFGNAGGTNVGFGNLGNGNVGFGNSGLGAGLAGLGNIGLGNAGSSNYG
FANLGVGNIGFGNTGTNNVGVGLTGNHLTGIGGLNSGTGNIGLFNSGTGNVGFFNSGT
GNFGVFNSGNYNTGVGNAGTASTGLFNAGNFNTGVVNVGSYNTGSFNAGDTNTGGFNP
GGVNTGWLNTGNTNTGIANSGNVNTGAFISGNFNNGVLWVGDYQGLFGVSAGSSIPAI
PIGLVLNGDIGPITIQPIPILPTIPLSIHQTVNLGPLVVPDIVIPAFGGGIGIPINIG
PLTITPITLFAQQTFVNQLPFPTFSLGKITIPQIQTFDSNGQLVSFIGPIVIDTTIPG
PTNPQIDLTIRWDTPPITLFPNGISAPDNPLGLLVSVSISNPGFTIPGFSVPAQPLPL
SIDIEGQIDGFSTPPITIDRIPLTVGGGVTIGPITIQGLHIPAAPGVGNTTTAPSSGF
FNSGAGGVSGFGNVGAGSSGWWNQAPSALLGAGSGVGNVGTLGSGVLNLGSGISGFYN
TSVLPFGTPAAVSGIGNLGQQLSGVSAAGTTLRSMLAGNLGLANVGNFNTGFGNVGDV
NLGAANIGGHNLGLGNVGDGNLGLGNIGHGNLGFANLGLTAGAAGVGNVGFGNAGINN
YGLANMGVGNIGFANTGTGNIGIGLVGDHRTGIGGLNSGIGNIGLFNSGTGNVGFFNS
GTGNFGIGNSGRFNTGIGNSGTASTGLFNAGSFSTGIANTGDYNTGSFNAGDTNTGGF
NPGGINTGWFNTGHANTGLANAGTFGTGAFMTGDYSNGLLWRGGYEGLVGVRVGPTIS
QFPVTVHAIGGVGPLHVAPVPVPAVHVEITDATVGLGPFTVPPISIPSLPIASITGSV
DLAANTISPIRALDPLAGSIGLFLEPFRLSDPFITIDAFQVVAGVLFLENIIVPGLTV
SGQILVTPTPIPLTLNLDTTPWTLFPNGFTIPAQTPVTVGMEVANDGFTFFPGGLTFP
RASAGVTGLSVGLDAFTLLPDGFTLDTVPATFDGTILIGDIPIPIIDVPAVPGFGNTT
TAPSSGFFNTGGGGGSGFANVGAGTSGWWNQGHDVLAGAGSGVANAGTLSSGVLNVGS
GISGWYNTSTLGAGTPAVVSGIGNLGQQLSGFLANGTVLNRSPIVNIGWADVGAFNTG
LGNVGDLNWGAANIGAQNLGLGNLGSGNVGFGNIGAGNVGFANSGPAVGLAGLGNVGL
SNAGSNNWGLANLGVGNIGLANTGTGNIGIGLVGDYQTGIGGLNSGSGNIGLFNSGTG
NVGFFNTGTGNFGLFNSGSFNTGIGNSGTGSTGLFNAGNFNTGIANPGSYNTGSFNVG
DTNTGGFNPGDINTGWFNTGIMNTGTRNTGALMSGTDSNGMLWRGDHEGLFGLSYGIT
IPQFPIRITTTGGIGPIVIPDTTILPPLHLQITGDADYSFTVPDIPIPAIHIGINGVV
TVGFTAPEATLLSALKNNGSFISFGPITLSNIDIPPMDFTLGLPVLGPITGQLGPIHL
EPIVVAGIGVPLEIEPIPLDAISLSESIPIRIPVDIPASVIDGISMSEVVPIDASVDI
PAVTITGTTISAIPLGFDIRTSAGPLNIPIIDIPAAPGFGNSTQMPSSGFFNTGAGGG
SGIGNLGAGVSGLLNQAGAGSLVGTLSGLGNAGTLASGVLNSGTAISGLFNVSTLDAT
TPAVISGFSNLGDHMSGVSIDGLIAILTFPPAESVFDQIIDAAIAELQHLDIGNALAL
GNVGGVNLGLANVGEFNLGAGNVGNINVGAGNLGGSNLGLGNVGTGNLGFGNIGAGNF
GFGNAGLTAGAGGLGNVGLGNAGSGSWGLANVGVGNIGLANTGTGNIGIGLTGDYRTG
IGGLNSGTGNLGLFNSGTGNIGFFNTGTGNFGLFNSGSYSTGVGNAGTASTGLFNAGN
FNTGLANAGSYNTGSLNVGSFNTGGVNPGTVNTGWFNTGHTNTGLFNTGNVNTGAFNS
GSFNNGALWTGDYHGLVGFSFSIDIAGSTLLDLNETLNLGPIHIEQIDIPGMSLFDVH
EIVEIGPFTIPQVDVPAIPLEIHESIHMDPIVLVPATTIPAQTRTIPLDIPASPGSTM
TLPLISMRFEGEDWILGSTAAIPNFGDPFPAPTQGITIHTGPGPGTTGELKISIPGFE
IPQIATTRFLLDVNISGGLPAFTLFAGGLTIPTNAIPLTIDASGALDPITIFPGGYTI
DPLPLHLALNLTVPDSSIPIIDVPPTPGFGNTTATPSSGFFNSGAGGVSGFGNVGSNL
SGWWNQAASALAGSGSGVLNVGTLGSGVLNVGSGVSGIYNTSVLPLGTPAVLSGLGNV
GHQLSGVSAAGTALNQIPILNIGLADVGNFNVGFGNVGDVNLGAANLGAQNLGLGNVG
TGNLGFANVGHGNIGFGNSGLTAGAAGLGNTGFGNAGSANYGFANQGVRNIGLANTGT
GNIGIGLVGDNLTGIGGLNSGAGNIGLFNSGTGNIGFFNSGTGNFGIGNSGSFNTGIG
NSGTGSTGLFNAGSFNTGVANAGSYNTGSFNAGDTNTGGFNPGTINTGWFNTGHTNTG
IANSGNVGTGAFMSGNFSNGLLWRGDHEGLFSLFYSLDVPRITIVDAHLDGGFGPVVL
PPIPVPAVNAHLTGNVAMGAFTIPQIDIPALTPNITGSAAFRIVVGSVRIPPVSVIVE
QIINASVGAEMRIDPFEMWTQGTNGLGITFYSFGSADGSPYATGPLVFGAGTSDGSHL
TISASSGAFTTPQLETGPITLGFQVPGSVNAITLFPGGLTFPATSLLNLDVTAGAGGV
DIPAITWPEIAASADGSVYVLASSIPLINIPPTPGIGNSTITPSSGFFNAGAGGGSGF
GNFGAGTSGWWNQAHTALAGAGSGFANVGTLHSGVLNLGSGVSGIYNTSTLGVGTPAL
VSGLGNVGHQLSGLLSGGSAVNPVTVLNIGLANVGSHNAGFGNVGEVNLGAANLGAHN
LGFGNIGAGNLGFGNIGHGNVGVGNSGLTAGVPGLGNVGLGNAGGNNWGLANVGVGNI
GLANTGTGNIGIGLTGDYQTGIGGLNSGAGNLGLFNSGAGNVGFFNTGTGNFGLFNSG
SFNTGVGNSGTGSTGLFNAGSFNTGVANAGSYNTGSFNVGDTNTGGFNPGSINTGWLN
AGNANTGVANAGNVNTGAFVTGNFSNGILWRGDYQGLAGFAVGYTLPLFPAVGADVSG
GIGPITVLPPIHIPPIPVGFAAVGGIGPIAIPDISVPSIHLGLDPAVHVGSITVNPIT
VRTPPVLVSYSQGAVTSTSGPTSEIWVKPSFFPGIRIAPSSGGGATSTQGAYFVGPIS
IPSGTVTFPGFTIPLDPIDIGLPVSLTIPGFTIPGGTLIPTLPLGLALSNGIPPVDIP
AIVLDRILLDLHADTTIGPINVPIAGFGGAPGFGNSTTLPSSGFFNTGAGGGSGFSNT
GAGMSGLLNAMSDPLLGSASGFANFGTQLSGILNRGAGISGVYNTGALGVVTAAVVSG
FGNVGQQLSGLLFTGVGP"
gene complement(3767346..3768140)
/locus_tag="Rv3351c"
CDS complement(3767346..3768140)
/codon_start=1
/transl_table=11
/locus_tag="Rv3351c"
/product="Conserved hypothetical protein"
/note="Rv3351c, (MTV004.08c), len: 264 aa. Hypothetical
protein, highly similar to C-terminal region (aa 292-479)
of O53608|Rv0063|MTV030.06 oxidoreductase from
Mycobacterium tuberculosis (479 aa), FASTA scores: opt:
699, E(): 1.7e-36, (54.75% identity in 190 aa overlap).
Shows some similarity to Q9KYD6|SCD72A.20 putative
lipoprotein (fragment) from Streptomyces coelicolor (403
aa), FASTA scores: opt: 192, E(): 9.1e-05, (27.9% identity
in 154 aa overlap); and P71091|YGAK hypothetical 54.4 KDA
protein from Bacillus subtilis (480 aa), FASTA scores:
opt: 174, E(): 0.0014, (26.5% identity in 166 aa overlap).
Note that the two upstream ORFs Rv3352c and Rv3353c also
show similarity to Rv0063 (MTV030_7). Sequence was checked
but no errors found. Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3351c"
/db_xref="EnsemblGenomes-Tr:CCP46172"
/db_xref="GOA:O50380"
/db_xref="InterPro:IPR012951"
/db_xref="UniProtKB/TrEMBL:O50380"
/protein_id="CCP46172.1"
/translation="MLASCPARSGAAVADAIKSAVGVQPSGVEHKTLRRMDLVRYLAG
GHTTYPPEGFVAGSDVIGTTNPAAAQAIVAAIGTWPPAAGRASALIDSLGGAVGDMDP
EGSAFPWCRQSAVVQWYVNTPSDGQVATANKWLSDAHHAVQHFSVGGYVNYLEANAAA
SQYFGANLSRLTTVRRKYDPDRIMYSGLDFSTRQVAERLLPALGFRVRFGVLVIRCAL
CTDTVKRLGTLPNLTWSRLKVNVAVTQEQAGVMDLPALPVRRTPRR"
gene complement(3768222..3768593)
/locus_tag="Rv3352c"
CDS complement(3768222..3768593)
/codon_start=1
/transl_table=11
/locus_tag="Rv3352c"
/product="Possible oxidoreductase"
/note="Rv3352c, (MTV004.09c), len: 123 aa. Possible
oxidoreductase, similar to part of several oxidoreductases
(and hypothetical proteins) from diverse organisms e.g.
Q9KYD6|SCD72A.20 putative lipoprotein (fragment) from
Streptomyces coelicolor (403 aa), FASTA scores: opt:
348,E(): 7.9e-15, (51.0% identity in 102 aa overlap);
BAB53081|MLR6875 probable oxidoreductase from Rhizobium
loti (Mesorhizobium loti) (479 aa), FASTA scores: opt:
262,E(): 2.3e-09, (53.85% identity in 78 aa overlap);
O94206|OX1 oxidoreductase from Claviceps purpurea (Ergot
fungus) (483 aa), FASTA scores: opt: 245, E():
2.7e-08,(42.6% identity in 115 aa overlap); Q9KHK2|ENCM
putative FAD-dependent oxygenase ENCM from Streptomyces
maritimus (464 aa), FASTA scores: opt: 238, E(): 7.2e-08,
(43.95% identity in 91 aa overlap); etc. Also highly
similar to part of O53608|Rv0063|MTV030.06 oxidoreductase
(479 aa),FASTA scores: opt: 599, E(): 1.6e-30, (71.55%
identity in 123 aa overlap); and to other Mycobacterium
tuberculosis proteins e.g. Rv3353c and Rv3351c. All show
similarity to a family of oxidoreductases in Mycobacterium
tuberculosis,suggesting that frameshift mutations may have
occurred. Sequence has been checked but no errors were
found."
/db_xref="EnsemblGenomes-Gn:Rv3352c"
/db_xref="EnsemblGenomes-Tr:CCP46173"
/db_xref="GOA:O50381"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR036318"
/db_xref="UniProtKB/TrEMBL:O50381"
/protein_id="CCP46173.1"
/translation="MSAATDLYAVHQALAGESRAIPTGSCPTVGVAGLTLGGGLGADS
RHAGLTCDALKSATVVLPGGDAVSASADDHAELFWALRGGGGGNFGVTTSMTFARFPT
ADCDVVRVDFAPSAAAQVLVG"
gene complement(3768736..3768996)
/locus_tag="Rv3353c"
CDS complement(3768736..3768996)
/codon_start=1
/transl_table=11
/locus_tag="Rv3353c"
/product="Conserved hypothetical protein"
/note="Rv3353c, (MTV004.10c), len: 86 aa. Hypothetical
protein, showing some similarity to Q9X5Q4|MITR MITR
protein from Streptomyces lavendulae (514 aa), FASTA
scores: opt: 134, E(): 0.09, (29.5% identity in 78 aa
overlap); and weak to Q49720|B1549_C3_218 from
Mycobacterium leprae (222 aa), FASTA scores: opt: 99, E():
8.8, (32.9% identity in 76 aa overlap). But highly similar
to N-terminal part of O53608|Rv0063|MTV030.06
oxidoreductase from Mycobacterium tuberculosis (479
aa),FASTA scores: opt: 305, E(): 4.9e-13, (52.9% identity
in 87 aa overlap); and some similarity can be found with
Rv3352c and Rv3351c. All show similarity to a family of
oxidoreductases in Mycobacterium tuberculosis, suggesting
that frameshift mutations may have occurred. Sequence has
been checked but no errors were found. Start changed since
original submission."
/db_xref="EnsemblGenomes-Gn:Rv3353c"
/db_xref="EnsemblGenomes-Tr:CCP46174"
/db_xref="UniProtKB/TrEMBL:O50382"
/protein_id="CCP46174.1"
/translation="MSRQTFLRGAVGAPATSAVFPTILARATPGDGWASLASSIGGQV
LLPANGRAFTSGKQIFNSNYSGLNPAAVVTVASQADVRKAVS"
gene 3769111..3769500
/locus_tag="Rv3354"
CDS 3769111..3769500
/codon_start=1
/transl_table=11
/locus_tag="Rv3354"
/product="Conserved hypothetical protein"
/note="Rv3354, (MTV004.11), len: 129 aa. Conserved
hypothetical protein, equivalent (but shorter 29 aa) to
Q9CCM4|ML0676 hypothetical protein from Mycobacterium
leprae (158 aa), FASTA scores: opt: 467, E():
3.3e-21,(55.9% identity in 127 aa overlaps). Highly
similar to O33192|LPRJ|Rv1690|MTCI125.12 hypothetical
protein from Mycobacterium tuberculosis (127 aa), FASTA
scores: opt: 329, E(): 4.7e-13, (46.95% identity in 115 aa
overlap); and also similar to other Mycobacterium
tuberculosis hypothetical proteins e.g.
O07222|Rv1810|MTCY16F9.04c (118 aa), FASTA scores: opt:
195, E(): 4.2e-05, (37.15% identity in 113 aa overlap);
MTCI125_11, MTCY16F9_4, MTV049_25. A core mycobacterial
gene; conserved in mycobacterial strains (See Marmiesse et
al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3354"
/db_xref="EnsemblGenomes-Tr:CCP46175"
/db_xref="GOA:O50383"
/db_xref="InterPro:IPR007969"
/db_xref="UniProtKB/TrEMBL:O50383"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46175.1"
/translation="MNLRRHQTLTLRLLAASAGILSAAAFAAPAQANPVDDAFIAALN
NAGVNYGDPVDAKALGQSVCPILAEPGGSFNTAVASVVARAQGMSQDMAQTFTSIAIS
MYCPSVMADVASGNLPALPDMPGLPGS"
gene complement(3769514..3769807)
/locus_tag="Rv3355c"
CDS complement(3769514..3769807)
/codon_start=1
/transl_table=11
/locus_tag="Rv3355c"
/product="Probable integral membrane protein"
/note="Rv3355c, (MTV004.12c), len: 97 aa. Probable
integral membrane protein, equivalent to
O32878|MLCB1779.16c|ML0675 hypothetical 9.6 KDA protein
from Mycobacterium leprae (91 aa), FASTA scores: opt: 439,
E(): 3.9e-23, (78.9% identity in 90 aa overlap).
Identical, but with a gap, to O50377|Rv3346c|MTV004.02c
hypothetical 8.9 KDA protein from Mycobacterium
tuberculosis (85 aa), FASTA scores: opt: 413,E(): 2.1e-21,
(85.55% identity in 97 aa overlap). Also some similarity
to other proteins e.g. Q9K3J5|SC2A6.10 putative integral
membrane protein from Streptomyces coelicolor (178 aa),
FASTA scores: opt: 147, E(): 0.003, (31.25% identity in 80
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3355c"
/db_xref="EnsemblGenomes-Tr:CCP46176"
/db_xref="GOA:O50384"
/db_xref="InterPro:IPR021385"
/db_xref="UniProtKB/TrEMBL:O50384"
/protein_id="CCP46176.1"
/translation="MTVRAVFRRTVGAQWPILLVGSIFAVGFVLAGANFWRRGALLIG
IGVGVAAVLRLVLSEERAGLLVVRSKGIDFVTTVTVAAAMVYIASTIDPLGTG"
repeat_region 3769514..3769720
/note="207 bp imperfect direct repeat 2, 199/207 bp
identical to first copy at 3743198..3743404"
repeat_region 3769754..3769862
/note="109 bp imperfect direct repeat 2, 95/109 bp
identical to first copy at 3743402..3743510"
gene complement(3769804..3770649)
/gene="folD"
/locus_tag="Rv3356c"
CDS complement(3769804..3770649)
/codon_start=1
/transl_table=11
/gene="folD"
/locus_tag="Rv3356c"
/product="Probable bifunctional protein FolD:
methylenetetrahydrofolate dehydrogenase +
methenyltetrahydrofolate cyclohydrolase"
/note="Rv3356c, (MTV004.13c), len: 281 aa. Probable
folD,bifunctional enzyme include methylenetetrahydrofolate
dehydrogenase and methenyltetrahydrofolate cyclohydrolase
,equivalent to O32879|fold|ML0674
methylenetetrahydrofolate dehydrogenase (putative
methylenetetrahydrofolate
dehydrogenase/methenyltetrahydrofolate cyclohydrolase)
from Mycobacterium leprae (282 aa), FASTA scores: opt:
1624,E(): 1.2e-93, (86.45% identity in 281 aa overlap).
Also similar to many others e.g. Q9K3J6|fold from
Streptomyces coelicolor (284 aa), FASTA scores: opt: 1223,
E(): 9.5e-69,(66.65% identity in 279 aa overlap);
Q9K966|fold from Bacillus halodurans (279 aa), FASTA
scores: opt: 886, E(): 7.7e-48, (47.15% identity in 280 aa
overlap); P54382|FOLD_BACSU from Bacillus subtilis (283
aa), FASTA scores: opt: 820, E(): 9.7e-44, (45.7% identity
in 280 aa overlap); P51696|FOLD_PHOPO from Photobacterium
phosphoreum (285 aa), FASTA scores: opt: 778, E(): 4e-41,
(44.9% identity in 283 aa overlap);
P24186|FOLD_ECOLI|ads|B0529 from Escherichia coli (287
aa), FASTA scores: opt: 741,E(): 0,44.4, (44.4% identity
in 277 aa overlap); etc. Also highly similar to MLCB1779_9
from Mycobacterium leprae cosmid B1779 (282 aa) (86.5%
identity in 281 aa overlap). Similar to other
dehydrogenase/cyclohydrolase enzymes or domains."
/db_xref="EnsemblGenomes-Gn:Rv3356c"
/db_xref="EnsemblGenomes-Tr:CCP46177"
/db_xref="GOA:P9WG81"
/db_xref="InterPro:IPR000672"
/db_xref="InterPro:IPR020630"
/db_xref="InterPro:IPR020631"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:2C2X"
/db_xref="PDB:2C2Y"
/db_xref="UniProtKB/Swiss-Prot:P9WG81"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46177.1"
/translation="MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDP
GSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPK
HLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAH
VVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLT
ADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVE
LAERR"
gene 3770773..3771048
/gene="relJ"
/gene_synonym="relB3"
/gene_synonym="yefM"
/locus_tag="Rv3357"
CDS 3770773..3771048
/codon_start=1
/transl_table=11
/gene="relJ"
/gene_synonym="relB3"
/gene_synonym="yefM"
/locus_tag="Rv3357"
/product="Antitoxin RelJ"
/note="Rv3357, (MTV004.14), len: 91 aa. RelJ,
antitoxin,part of toxin-antitoxin (TA) operon with Rv3358
(See Cherny et al., 2004; Pandey and Gerdes, 2005), highly
similar to other hypothetical proteins e.g.
Q9Z4V7|YU1E_STRCO (alias CAC37261|SCBAC17D6.02) ORFU1E
(belongs to the PHD/YEFM family) from Streptomyces
coelicolor (87 aa), FASTA scores: opt: 344, E(): 1.9e-17,
(62.05% identity in 87 aa overlap);
P46147|YEFM_ECOLI|B2017 from Escherichia coli strain K12
(83 aa), FASTA scores: opt: 215, E(): 1.6e-08, (50.0%
identity in 72 aa overlap); BAB58570|SAV2408 from
Staphylococcus aureus subsp. aureus Mu50 (83 aa), FASTA
scores: opt: 161, E(): 8.8e-05, (39.95% identity in 77 aa
overlap); Q9Z5W8 putative PHD protein from Francisella
novicid (85 aa), FASTA scores: opt: 143, E():
0.0016,(28.9% identity in 83 aa overlap); etc. Also
similar to Rv1247c|MTV006.19c (89 aa) (36.9% identity in
84 aa overlap). Seems to belong to the PHD/YEFM family."
/db_xref="EnsemblGenomes-Gn:Rv3357"
/db_xref="EnsemblGenomes-Tr:CCP46178"
/db_xref="GOA:P9WF25"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="PDB:3CTO"
/db_xref="PDB:3D55"
/db_xref="PDB:3OEI"
/db_xref="UniProtKB/Swiss-Prot:P9WF25"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46178.1"
/translation="MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYD
AWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSVDELREMAGGEE"
repeat_region 3770994..3771091
/note="98 bp imperfect direct repeat 2, 82/98 bp identical
to the first copy at 3743508..3743605"
gene 3771045..3771302
/gene="relK"
/gene_synonym="relE3"
/gene_synonym="yoeB"
/locus_tag="Rv3358"
CDS 3771045..3771302
/codon_start=1
/transl_table=11
/gene="relK"
/gene_synonym="relE3"
/gene_synonym="yoeB"
/locus_tag="Rv3358"
/product="Toxin RelK"
/note="Rv3358, (MTV004.15), len: 85 aa. RelK, toxin, part
of toxin-antitoxin (TA) operon with Rv3357 (See Cherny et
al., 2004; Pandey and Gerdes, 2005), highly similar to
other hypohetical proteins e.g. Q9Z4V8|SCBAC17D6.03 from
Streptomyces coelicolor (84 aa), FASTA scores: opt:
393,E(): 1.1e-21, (59.75% identity in 82 aa overlap);
P56605|YOEB_ECOLI from Escherichia coli (84 aa), FASTA
scores: opt: 305, E(): 2.2e-15, (49.35% identity in 77 aa
overlap); Q9Z5W7 putative doc protein from Francisella
novicida (68 aa), FASTA scores: opt: 253, E():
9.6e-12,(51.6% identity in 62 aa overlap);
BAB58569|SAV2407 from Staphylococcus aureus subsp. aureus
Mu50 (88 aa), FASTA scores: opt: 250, E(): 2e-11, (40.5%
identity in 84 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3358"
/db_xref="EnsemblGenomes-Tr:CCP46179"
/db_xref="GOA:P9WF09"
/db_xref="InterPro:IPR009614"
/db_xref="InterPro:IPR035093"
/db_xref="PDB:3OEI"
/db_xref="UniProtKB/Swiss-Prot:P9WF09"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46179.1"
/translation="MRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIG
KPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLKARYHY"
gene 3771344..3772534
/locus_tag="Rv3359"
CDS 3771344..3772534
/codon_start=1
/transl_table=11
/locus_tag="Rv3359"
/product="Possible oxidoreductase"
/note="Rv3359, (MTV004.16), len: 396 aa. Possible
oxidoreductase, similar to N-terminal part of various
proteins (hypothetical unknowns or oxidoreductases) e.g.
Q9ZB94 hypothetical 69.3 KDA protein from Rhodococcus
erythropolis (649 aa), FASTA scores: opt: 509, E():
3e-24,(30.0% identity in 380 aa overlap); O29991|AF0248
NADH-dependent flavin oxidoreductase from Archaeoglobus
fulgidus (378 aa), FASTA scores: opt: 478, E():
1.6e-22,(32.45% identity in 379 aa overlap); Q9HUH9|PA4986
probable oxidoreductase from Pseudomonas aeruginosa (648
aa), FASTA scores: opt: 412, E(): 3.3e-18, (30.45%
identity in 384 aa overlap); Q9KCT8|BH1481 NADH oxidase
from Bacillus halodurans (338 aa), FASTA scores: opt: 404,
E(): 6.1e-18,(30.2% identity in 275 aa overlap); etc. Some
weak similarity to Mycobacterium leprae MLCB1779_10."
/db_xref="EnsemblGenomes-Gn:Rv3359"
/db_xref="EnsemblGenomes-Tr:CCP46180"
/db_xref="GOA:O50388"
/db_xref="InterPro:IPR001155"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:O50388"
/protein_id="CCP46180.1"
/translation="MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVTDD
LIEYHRLPAAGGVAMTTVAYCAVSPGGRTGGNQIWMRPHAVPGLRRLTEAIHAEGAAI
SAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKATREDIDDVLAAHAHAARLAV
DAGFDAVEIHLGHNYLASAFLSPLLNRRDDEFGGSLQNRAKVARGLVMAVRRAVRQQV
AVTAKLNMTDGIRGGITVDEALTTARWLQDDGGLDAIELTAGSSLVNPMYLFRGDAPV
KEFAAAFKPPLRWGIRMTGHRFFREYPYRDAYLLREARLFRAELTIPLILLGGITNRT
TMDLAMAEGFEFVAMARALLAEPDLVNRIAAEGSQVRSACTHCNQCMATIYRRTHCVV
TGAP"
gene 3772651..3773019
/locus_tag="Rv3360"
CDS 3772651..3773019
/codon_start=1
/transl_table=11
/locus_tag="Rv3360"
/product="Conserved hypothetical protein"
/note="Rv3360, (MTV004.17), len: 122 aa. Hypothetical
protein, highly similar to the N-terminus of
O65934|Rv1747|MTCY28.10|MTCY04C12.31 probable
ABC-transporter ATP-binding protein from Mycobacterium
tuberculosis (865 aa), FASTA scores: opt: 480, E():
4.7e-25, (61.0% identity in 118 aa overlap); and some
similarity with the N-terminus of
P96214|Rv3863|MTCY01A6.05c hypothetical 41.1 KDA protein
from Mycobacterium tuberculosis (392 aa), FASTA scores:
opt: 138, E(): 0.033, (31.95% identity in 97 aa overlap).
Some weak similarity with the N-terminus of other
hypothetical proteins e.g. P73823|CYAA|SLR1991 adenylate
cyclase from Synechocystis sp. strain PCC 6803 (337
aa),FASTA scores: opt: 127, E(): 0.16, (28.55% identity in
112 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3360"
/db_xref="EnsemblGenomes-Tr:CCP46181"
/db_xref="InterPro:IPR000253"
/db_xref="InterPro:IPR008984"
/db_xref="UniProtKB/TrEMBL:O50389"
/protein_id="CCP46181.1"
/translation="MSRPHPPVLTVRSDRSQQCFAAGRDVVVGSDLRADMRVAHPLIA
RAHLLLRFDRGNWIAIDNDSQSGMFVDGQRVSEVDIYDGLTINIGKPTGPWITFEVGH
HQGIIGRLSRTPSSRPGSPI"
gene complement(3773016..3773567)
/locus_tag="Rv3361c"
CDS complement(3773016..3773567)
/codon_start=1
/transl_table=11
/locus_tag="Rv3361c"
/product="Conserved protein"
/note="Rv3361c, (MTV004.18c), len: 183 aa. Conserved
protein, with some similarity to various proteins e.g.
P74221|YB52_SYNY3|SLR1152 hypothetical 36.2 KDA protein
SLR (contains 5 pentapeptide repeat domains) from
Synechocystis sp. strain PCC 6803 (331 aa), FASTA scores:
opt: 252, E(): 3.9e-10, (30.55% identity in 167 aa
overlap); Q9SE95 FH protein interacting protein FIP2 from
Arabidopsis thaliana (Mouse-ear cress) (298 aa), FASTA
scores: opt: 207, E(): 4.4e-07, (30.35% identity in 168 aa
overlap); Q9A735|CC1891 pentapeptide repeat family protein
from Caulobacter crescentus (250 aa), FASTA scores: opt:
181, E(): 2.3e-05,(24.05% identity in 187 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3361c"
/db_xref="EnsemblGenomes-Tr:CCP46182"
/db_xref="InterPro:IPR001646"
/db_xref="PDB:2BM4"
/db_xref="PDB:2BM5"
/db_xref="PDB:2BM6"
/db_xref="PDB:2BM7"
/db_xref="UniProtKB/Swiss-Prot:I6YBX3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46182.1"
/translation="MQQWVDCEFTGRDFRDEDLSRLHTERAMFSECDFSGVNLAESQH
RGSAFRNCTFERTTLWHSTFAQCSMLGSVFVACRLRPLTLDDVDFTLAVLGGNDLRGL
NLTGCRLRETSLVDTDLRKCVLRGADLSGARTTGARLDDADLRGATVDPVLWRTASLV
GARVDVDQAVAFAAAHGLCLAGG"
gene complement(3773574..3774155)
/locus_tag="Rv3362c"
CDS complement(3773574..3774155)
/codon_start=1
/transl_table=11
/locus_tag="Rv3362c"
/product="Probable ATP/GTP-binding protein"
/note="Rv3362c, (MTV004.19c), len: 193 aa. Probable
ATP/GTP-binding protein, similar to others from
Streptomyces coelicolor e.g. O86519|SC1C2.18c (174
aa),FASTA scores: opt: 731, E(): 9.8e-41, (66.85% identity
in 169 aa overlap); Q9XAE1|SC6G9.41c (191 aa), FASTA
scores: opt: 730, E(): 1.2e-40, (63.55% identity in 173 aa
overlap); Q9L235|SC1A2.06 (184 aa), FASTA scores: opt:
650,E(): 1.9e-35, (55.95% identity in 177 aa overlap);
Q9RJ74|SCI41.10c (176 aa), FASTA scores: opt: 618, E():
2.3e-33, (55.9% identity in 161 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3362c"
/db_xref="EnsemblGenomes-Tr:CCP46183"
/db_xref="InterPro:IPR004130"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O50391"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46183.1"
/translation="MALKHSEASGTASTKIVIAGGFGSGKTTFVGAVSEIMPLRTEAM
VTDASAGVDMLEATPDKRSTTVAMDFGRITLGEDLVLYLFGTPGQRRFWFMWDDLVRG
AIGAIVLVDCRRLQDSFAAVDFFEHRNLPFLIAINEFDSAPRYPVSAVRDALTLPAHI
PVINVDARNRRSATDALIAVSEYALATLSPAGG"
gene complement(3774136..3774504)
/locus_tag="Rv3363c"
CDS complement(3774136..3774504)
/codon_start=1
/transl_table=11
/locus_tag="Rv3363c"
/product="Conserved hypothetical protein"
/note="Rv3363c, (MTV004.20c), len: 122 aa. Conserved
hypothetical protein, similar to others from Streptomyces
coelicolor e.g. O86523|SC1C2.23c (132 aa), FASTA scores:
opt: 236, E(): 9e-09, (38.5% identity in 122 aa overlap);
O86520|SC1C2.19c (190 aa), FASTA scores: opt: 231, E():
2.7e-08, (41.0% identity in 122 aa overlap);
Q9X834|SC9B1.14c (119 aa), FASTA scores: opt: 188, E():
1.1e-05, (37.5% identity in 120 aa overlap);
Q9ADJ4|SCBAC14E8.05 (113 aa), FASTA scores: opt: 167, E():
0.00025, (33.05% identity in 109 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3363c"
/db_xref="EnsemblGenomes-Tr:CCP46184"
/db_xref="GOA:O50392"
/db_xref="InterPro:IPR007995"
/db_xref="UniProtKB/TrEMBL:O50392"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46184.1"
/translation="MFNPAGDRPKAGLVRPYTLTAGRTGTDVDLPLQAPVQTLPAGPA
GRWPAYDMRRRILQLCIGSPSVAEISARLDLPVGVARVLVGDLVTSGYLRVHATLTDR
STRDERHELIGRTLRGLKAL"
gene complement(3774482..3774874)
/locus_tag="Rv3364c"
CDS complement(3774482..3774874)
/codon_start=1
/transl_table=11
/locus_tag="Rv3364c"
/product="Conserved protein"
/note="Rv3364c, (MTV004.21c), len: 130 aa. Conserved
protein, highly similar to others from Streptomyces
coelicolor e.g. O86524|SC1C2.24c (137 aa), FASTA scores:
opt: 466, E(): 1.3e-22, (58.6% identity in 116 aa
overlap); O86521|SC1C2.20c (140 aa), FASTA scores: opt:
445, E(): 2.7e-21, (56.9% identity in 116 aa overlap);
Q9KZI6|SCG8A.13c (145 aa), FASTA scores: opt: 341, E():
9.5e-15, (51.3% identity in 113 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3364c"
/db_xref="EnsemblGenomes-Tr:CCP46185"
/db_xref="GOA:O50393"
/db_xref="InterPro:IPR004942"
/db_xref="UniProtKB/Swiss-Prot:O50393"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46185.1"
/translation="MKARLPDSPLDWLVSKFAREVPGVAHALLVSVDGLPVAASEHLP
RERADQLAAVTSGLASLAGGAAQLFDGGQVLQSVVEMQNGYLLLMQVGDGSALAALAA
TGCDIGQIGYEMAILVERVGGVVQSCRR"
gene complement(3774871..3777501)
/locus_tag="Rv3365c"
CDS complement(3774871..3777501)
/codon_start=1
/transl_table=11
/locus_tag="Rv3365c"
/product="Conserved protein"
/note="Rv3365c, (MTV004.22c), len: 876 aa. Conserved
protein, similar to various proteins from Streptomyces
coelicolor e.g. O86525|SC1C2.25c hypothetical 139.7 KDA
protein (similar to other prokaryotic sensory transduction
histidine kinases) (1329 aa), FASTA scores: opt: 879, E():
5.4e-32, (29.9% identity in 924 aa overlap) (similarity in
N-terminal part for this one); O86522|SC1C2.21c
hypothetical 119.9 KDA protein (similar to other
prokaryotic sensory transduction histidine kinases) (1111
aa), FASTA scores: opt: 855, E(): 5.6e-31, (28.9% identity
in 892 aa overlap) (similarity in N-terminal part for this
one); Q9KZI5|SCG8A.14c putative membrane protein (862
aa),FASTA scores: opt: 791, E(): 3.3e-28, (30.8% identity
in 828 aa overlap); Q9KZN0|SC1A8A.22c (943 aa), FASTA
scores: opt: 660, E(): 2.5e-22, (27.65% identity in 893 aa
overlap); etc. Similar in part to two consecutive
Mycobacterium leprae hypothetical ORFs, probably
representing a pseudogene: O07701|MLCL383.27 (118
aa),FASTA scores: opt: 430, E(): 1e-12, (58.25% identity
in 115 aa overlap); and O07700|MLCL383.26 (111 aa), FASTA
scores: opt: 271, E(): 1.3e-05, (50.4% identity in 121 aa
overlap). Contains PS00142 Neutral zinc
metallopeptidases,zinc-binding region signature."
/db_xref="EnsemblGenomes-Gn:Rv3365c"
/db_xref="EnsemblGenomes-Tr:CCP46186"
/db_xref="GOA:Q93IG6"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/TrEMBL:Q93IG6"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46186.1"
/translation="MTMFARPTIPVAAAASDISAPAQPARGKPQQRPPSWSPRNWPVR
WKVFTIALLPLVVAMVLAGLRVEAAMASTSGLRLVAARAEMIPAITKYMSALDVAVLA
SSTGHDVEGAQKNFTARKYELQTRLADTDVIADVRSGVNTLLNGGQALLDKVLADSIG
LRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQEILVTRGA
DLAEPQLRSAMVTLAGTEPSTLFGMSAALGAGSPDTKNLQQQMVTRMAIMSDPAVALV
NNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIV
VVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVA
HAVDELHTRALLLAGEETRLRLLVNEMFETMSRRSRSLVDQQLSVIDQLERNEEDPAR
LDSLFRLDHLAARLRRNSANLLVLAGAQITRDHREPVPLSTVISAAVSEVEDYRRVDI
ARVPDCAVVGAAAGGVIHLLAELIDNALRYSSPTTPVRVAAAIGSEGSVLLRISDSGL
GMTDADRRMANMRLRAGGEVTPDSARHMGLFVVGRLAGRHGIRVGLRGPVTGEQGTGT
TAEVYLPLAVLEGTAPAQPPKPRVFAIKPPCPEPAAADPTDVPAAIGPLPPVTLLPRR
TPGSSGIADVPAQPMQQRRRELKTPWWEDRFQQEPKQPPAPEPRPAPPPAKPAPPAGP
VDDDVIYRRMLSEMVGDPHELAHSPDLDWKSVWDHGWSAAAEAADKPVQSRTDYGLPV
REPGARLVPGAAVPEGPDREHPGAALASNGGLHPGRAPRHAAAVRDPDAVRASISSHF
GGVRTGRSHARESSQGPNQQ"
gene 3777737..3778201
/gene="spoU"
/locus_tag="Rv3366"
CDS 3777737..3778201
/codon_start=1
/transl_table=11
/gene="spoU"
/locus_tag="Rv3366"
/product="Probable tRNA/rRNA methylase SpoU (tRNA/rRNA
methyltransferase)"
/note="Rv3366, (MTV004.23), len: 154 aa. Probable
spoU,tRNA/rRNA methylase, equivalent to Q9CCU7|ML0419
putative tRNA/rRNA methyltransferase from Mycobacterium
leprae (158 aa), FASTA scores: opt: 861, E(): 1.2e-50,
(83.75% identity in 154 aa overlap); and
O07698|MLCL383.24c rRNA methylase from Mycobacterium
leprae (169 aa), FASTA scores: opt: 861,E(): 1.3e-50,
(83.75% identity in 154 aa overlap). Also highly similar
to many members of the spoU family of rRNA methylases e.g.
Q9K199|NMB0268 RNA methyltransferase (TRMH family) from
Neisseria meningitidis (serogroup B) (154 aa),FASTA
scores: opt: 534, E(): 7.6e-29, (50.0% identity in 154 aa
overlap); and Q9JSM8|NMA2218 from Neisseria meningitidis
(serogroup A) (154 aa), FASTA scores: opt: 526, E():
2.6e-28, (49.35% identity in 154 aa overlap);
Q9HU57|PA5127 from Pseudomonas aeruginosa (153 aa), FASTA
scores: opt: 531, E(): 1.2e-28, (52.95% identity in 151 aa
overlap); P33899|YIBK_ECOLI|B3606 from Escherichia coli
strain K12 (157 aa), FASTA scores: opt: 511, E():
2.6e-27,(49.35% identity in 154 aa overlap); etc. Belongs
to the RNA methyltransferase TrmH family."
/db_xref="EnsemblGenomes-Gn:Rv3366"
/db_xref="EnsemblGenomes-Tr:CCP46187"
/db_xref="GOA:O50394"
/db_xref="InterPro:IPR001537"
/db_xref="InterPro:IPR016914"
/db_xref="InterPro:IPR029026"
/db_xref="InterPro:IPR029028"
/db_xref="UniProtKB/TrEMBL:O50394"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46187.1"
/translation="MFRLLFVSPRIAPNTGNAIRTCAATGCELHLVEPLGFDLSEPKL
RRAGLDYHDLASVTVHASLAHAWEALSPARVFAFTAQATTLFTNVGYRAGDVLMFGPE
PTGLDEATLADTHITGQVRIPMLAGRRSLNLSNAAAVAVYEAWRQHGFAGAV"
gene 3778568..3780334
/gene="PE_PGRS51"
/locus_tag="Rv3367"
CDS 3778568..3780334
/codon_start=1
/transl_table=11
/gene="PE_PGRS51"
/locus_tag="Rv3367"
/product="PE-PGRS family protein PE_PGRS51"
/note="Rv3367, (MTV004.25), len: 588 aa. PE_PGRS51, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan & Delogu
2002). Similar to many from Mycobacterium tuberculosis
strains H37Rv and CDC1551 e.g. O50415|Rv3388|MTV004.46
(731 aa), FASTA scores: opt: 1999, E(): 7.2e-72, (55.0%
identity in 620 aa overlap); and MTV004_44, MTV043_65,
MTV006_15, MTCY63_2,MTCY21B4_13, MTV023_21, MTV008_43,
MTCY24A1_4, MTV023_15; etc. Equivalent to AAK47814 from
Mycobacterium tuberculosis strain CDC1551 (628 aa) but
shorter 37 aa."
/db_xref="EnsemblGenomes-Gn:Rv3367"
/db_xref="EnsemblGenomes-Tr:CCP46188"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L0TCB8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46188.1"
/translation="MSFVVAVPEALAAAASDVANIGSALSAANAAAAAGTTGLLAAGA
DEVSAALASLFSGHAVSYQQVAAQATALHDQFVQALTGAGGSYALTEAANVQQNLLNA
INAPTQALLGRPLIGDGAVGTASSPDGQDGGLLFGNGGAGYNSAATPGMAGGNGGNAG
LIGNGGTGGSGGAGAAGGAGGSGGWLYGNGGNGGIGGNAIVAGGAGGNGGAGGAAGLW
GSGGSGGQGGNGLTGNDGVNPAPVTNPALNGAAGDSNIEPQTSVLIGTQGGDGTPGGA
GVNGGNGGAGGDANGNPANTSIANAGAGGNGAAGGDGGANGGAGGAGGQAASAGSSVG
GDGGNGGAGGTGTNGHAGGAGGAGGAGGRGGWLVGNGGNGGNGAAGGNGAIGGTGGAG
GVPANQGGNSALGTQPVGGDGGDGGNGGTGGTGGRGGDGGSGGAGGASGWLMGNGGNG
GNGGTGGSGGVGGNGGIGGDGAGGGNATSTSSIPFDAHGGNGGAGGDAGHGGTGGDGG
DGGHAGTGGRGGLLAGQHANSGNGGGGGTGGAGGTHGTPGSGNAGGTGTGNADSTNGG
PGSDGLGGDAFNGSRGTDGNPG"
gene complement(3780335..3780979)
/locus_tag="Rv3368c"
CDS complement(3780335..3780979)
/codon_start=1
/transl_table=11
/locus_tag="Rv3368c"
/product="Possible oxidoreductase"
/note="Rv3368c, (MTV004.26c), len: 214 aa. Possible
oxidoreductase, equivalent to O07697|MLCL383.23|ML0418
hypothetical 23.6 KDA protein (putative oxidoreductase)
from Mycobacterium leprae (210 aa), FASTA scores: opt:
1215, E(): 1.5e-74, (81.4% identity in 210 aa overlap).
Also similar to O30106|AF0131 putative NAD(P)H-flavin
oxidoreductase from Archaeoglobus fulgidus (194 aa), FASTA
scores: opt: 139, E(): 0.028, (29.0% identity in 207 aa
overlap); Q60049|NOX_THETH NADH dehydrogenase from Thermus
aquaticus (subsp. thermophilus) (205 aa), FASTA scores:
opt: 169, E(): 0.00028, (28.3% identity in 212 aa
overlap); and shows some similarity to other hypothetical
proteins (unknowns or oxidoreductases)."
/db_xref="EnsemblGenomes-Gn:Rv3368c"
/db_xref="EnsemblGenomes-Tr:CCP46189"
/db_xref="GOA:O50397"
/db_xref="InterPro:IPR000415"
/db_xref="InterPro:IPR029479"
/db_xref="UniProtKB/TrEMBL:O50397"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46189.1"
/translation="MTLNLSVDEVLTTTRSVRKRLDFDKPVPRDVLMECLELALQAPT
GSNSQGWQWVFVEDAAKKKAIADVYLANARGYLSGPAPEYPDGDTRGERMGRVRDSAT
YLAEHMHRAPVLLIPCLKGREDESAVGGVSFWASLFPAVWSFCLALRSRGLGSCWTTL
HLLDNGEHKVADVLGIPYDEYSQGGLLPIAYTQGIDFRPAKRLPAESVTHWNGW"
gene 3780978..3781412
/locus_tag="Rv3369"
CDS 3780978..3781412
/codon_start=1
/transl_table=11
/locus_tag="Rv3369"
/product="Conserved protein"
/note="Rv3369, (MTV004.27), len: 144 aa. Conserved
protein. C-terminus is similar to N-terminus of
O07696|MLCL383.22c hypothetical 14.7 KDA protein from
Mycobacterium leprae (131 aa), FASTA scores: opt: 174,
E(): 6e-05, (67.55% identity in 37 aa overlap). Also some
slight similarity to Q9EWU1|3SC5B7.08c from Streptomyces
coelicolor (153 aa),FASTA scores: opt: 125, E(): 0.13,
(31.05% identity in 116 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3369"
/db_xref="EnsemblGenomes-Tr:CCP46190"
/db_xref="GOA:O50398"
/db_xref="InterPro:IPR011576"
/db_xref="InterPro:IPR012349"
/db_xref="InterPro:IPR019966"
/db_xref="UniProtKB/TrEMBL:O50398"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46190.1"
/translation="MWAGYRWAMSVELTQEVSARLTSDLYGWLTTVARSGQPVPRLVW
FYFDGTDLTVYSMPQAAKVAHITAHPQVSLNLDSDGNGAGIIVVGGTAAVVATDVDCR
DDAPYWAKYREDAAKFGLTEAIAAYSTRLKITPTRVWTTPTG"
gene complement(3781501..3784740)
/gene="dnaE2"
/locus_tag="Rv3370c"
CDS complement(3781501..3784740)
/codon_start=1
/transl_table=11
/gene="dnaE2"
/locus_tag="Rv3370c"
/product="Probable DNA polymerase III (alpha chain) DnaE2
(DNA nucleotidyltransferase)"
/note="Rv3370c, (MTV004.28c), len: 1079 aa. Probable
dnaE2,DNA polymerase III, alpha chain (see citations
below),similar to many e.g. BAB51086|MLR4428 from
Rhizobium loti (Mesorhizobium loti) (1118 aa), FASTA
scores: opt: 1103,E(): 8.9e-59, (37.65% identity in 1075
aa overlap); Q9S291|SCI11.28c from Streptomyces coelicolor
(1185 aa),FASTA scores: opt: 937, E(): 1e-48, (33.4%
identity in 1090 aa overlap);
O67125|DP3A_AQUAE|DNAE|AQ_1008 from Aquifex aeolicus (1161
aa), FASTA scores: opt: 895, E(): 3.4e-46,(29.9% identity
in 1071 aa overlap); O51526|DP3A_BORBU from Borrelia
burgdorferi (Lyme disease spirochete) (1147 aa),FASTA
scores: opt: 835, E(): 1.4e-42, (30.05% identity in 888 aa
overlap); etc. Equivalent to AAK47817 from Mycobacterium
tuberculosis strain CDC1551 (1098 aa) but shorter 19 aa.
Also similar to Mycobacterium tuberculosis
DP3A_MYCTU|MTCY48.18c|dnaE1 (29.6% identity in 1110 aa
overlap). Belongs to DNA polymerase type-C family, DNAE
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3370c"
/db_xref="EnsemblGenomes-Tr:CCP46191"
/db_xref="GOA:P9WNT5"
/db_xref="InterPro:IPR003141"
/db_xref="InterPro:IPR004013"
/db_xref="InterPro:IPR004805"
/db_xref="InterPro:IPR011708"
/db_xref="InterPro:IPR016195"
/db_xref="InterPro:IPR023073"
/db_xref="InterPro:IPR029460"
/db_xref="InterPro:IPR040982"
/db_xref="UniProtKB/Swiss-Prot:P9WNT5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46191.1"
/translation="MERVLNGKPRHAGVPAFDADGDVPRSRKRGAYQPPGRERVGSSV
AYAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDV
RTVFGAELSLGATARTERPDPPGPHLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRY
DFDALTEAAGGHWHILTGCRKGHVRQALSQGGPAAAQRALADLVDRFTPSRVSIELTH
HGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAG
WLAPLGGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHT
EDSWLRSLVMAGARERYGPPKSAPRAYSQIEHELKVIAQLRFPGYFLVVHDITRFCRD
NDILCQGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDIDIDIESDQRE
KVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQVSHWTGQA
DDVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWARMANRSVLQWD
KDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARAD
SVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVHPYIRRRNGVDPVI
YEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGSKRSTERMRRLR
GRFYDGMRALHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAA
FCAALLRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHATCENAGTEVRLGLGAV
RYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSVPQVEALATAGALGCFGMSRREAL
WAAGAAATGRPDRLPGVGSSSHIPALPGMSELELAAADVWATGVSPDSYPTQFLRADL
DAMGVLPAERLGSVSDGDRVLIAGAVTHRQRPATAQGVTFINLEDETGMVNVLCTPGV
WARHRKLAHTAPALLIRGQVQNASGAITVVAERMGRLTLAVGARSRDFR"
gene 3784932..3786272
/locus_tag="Rv3371"
CDS 3784932..3786272
/codon_start=1
/transl_table=11
/locus_tag="Rv3371"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv3371, (MTV004.29), len: 446 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004),
similar to many Mycobacterium tuberculosis (strains H37Rv
and CDC1551) hypothetical proteins e.g.
O07035|YV30_MYCTU|Rv3130c|MTCY03A2.28|MTCY164.41c (463
aa),FASTA scores: opt: 556, E(): 7.7e-28, (44.95% identity
in 447 aa overlap); MTY20B11_9, MTCY28_26,
MTV013_8,MTCY21B4_43, MTCY493_29; etc. Also similar to
O07692|MLCL383_9|MLCL383.18c hypothetical 14.1 KDA protein
from Mycobacterium leprae (129 aa), FASTA scores: opt:
293,E(): 1.3e-11, (47.85% identity in 117 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3371"
/db_xref="EnsemblGenomes-Tr:CCP46192"
/db_xref="GOA:P9WKA9"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46192.1"
/translation="MAQLTALDAGFLKSRDPERHPGLAIGAVAVVNGAAPSYDQLKTV
LTERIKSIPRCTQVLATEWIDYPGFDLTQHVRRVALPRPGDEAELFRAIALALERPLD
PDRPLWECWIIEGLNGNRWAILIKIHHCMAGAMSAAHLLARLCDDADGSAFANNVDIK
QIPPYGDARSWAETLWRMSVSIAGAVCTAAARAVSWPAVTSPAGPVTTRRRYQAVRVP
RDAVDAVCHKFGVTANDVALAAITEGFRTVLLHRGQQPRADSLRTLEKTDGSSAMLPY
LPVEYDDPVRRLRTVHNRSQQSGRRQPDSLSDYTPLMLCAKMIHALARLPQQGIVTLA
TSAPRPRHQLRLMGQKMDQVLPIPPTALQLSTGIAVLSYGDELVFGITADYDAASEMQ
QLVNGIELGVARLVALSDDSVLLFTKDRRKRSSRALPSAARRGRPSVPTARARH"
gene 3786314..3787489
/gene="otsB2"
/locus_tag="Rv3372"
CDS 3786314..3787489
/codon_start=1
/transl_table=11
/gene="otsB2"
/locus_tag="Rv3372"
/product="Trehalose 6-phosphate phosphatase OtsB2
(trehalose-phosphatase) (TPP)"
/note="Rv3372, (MTV004.30), len: 391 aa.
otsB2,trehalose-6-phosphate phosphatase, equivalent to
Q49734|OTSB2|OTSP|B1620_F1_1|MLCL383.17c putative
trehalose-phosphatase from Mycobacterium leprae (429
aa),FASTA scores: opt: 1675, E(): 2.4e-91, (67.05%
identity in 425 aa overlap). Also weakly similar to
several trehalose phosphatases e.g. Q9C8B3|F10O5.8 from
Arabidopsis thaliana (Mouse-ear cress) (366 aa), FASTA
scores: opt: 432, E(): 3.1e-18, (36.65% identity in 281 aa
overlap); O27788|MTH1760 from Methanobacterium
thermoautotrophicum (264 aa), FASTA scores: opt: 347, E():
2.5e-13, (30.75% identity in 221 aa overlap); Q9FWQ2 from
Oryza sativa (Rice) (382 aa), FASTA scores: opt: 338, E():
1.1e-12,(32.5% identity in 320 aa overlap); etc. Also
similar to part of Mycobacterium tuberculosis
Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),
FASTA scores: opt: 1192, E(): 1.6e-62, (56.65% identity in
339 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3372"
/db_xref="EnsemblGenomes-Tr:CCP46193"
/db_xref="GOA:P9WFZ5"
/db_xref="InterPro:IPR003337"
/db_xref="InterPro:IPR006379"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="PDB:5GVX"
/db_xref="UniProtKB/Swiss-Prot:P9WFZ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46193.1"
/translation="MRKLGPVTIDPRRHDAVLFDTTLDATQELVRQLQEVGVGTGVFG
SGLDVPIVAAGRLAVRPGRCVVVSAHSAGVTAARESGFALIIGVDRTGCRDALRRDGA
DTVVTDLSEVSVRTGDRRMSQLPDALQALGLADGLVARQPAVFFDFDGTLSDIVEDPD
AAWLAPGALEALQKLAARCPIAVLSGRDLADVTQRVGLPGIWYAGSHGFELTAPDGTH
HQNDAAAAAIPVLKQAAAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDRVGEVAAAV
RTAEQRHALRVTTGREVIELRPDVDWDKGKTLLWVLDHLPHSGSAPLVPIYLGDDITD
EDAFDVVGPHGVPIVVRHTDDGDRATAALFALDSPARVAEFTDRLARQLREAPLRAT"
gene 3787726..3788367
/gene="echA18"
/locus_tag="Rv3373"
CDS 3787726..3788367
/codon_start=1
/transl_table=11
/gene="echA18"
/locus_tag="Rv3373"
/product="Probable enoyl-CoA hydratase EchA18 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv3373, (MTV004.31), len: 213 aa. Probable
echA18,enoyl-CoA hydratase, similar to others e.g.
P97087|CRT from Clostridium thermosaccharolyticum
(Thermoanaerobacterium thermosaccharolyticum) (259 aa),
FASTA scores: opt: 423,E(): 3.4e-20, (37.95% identity in
174 aa overlap); Q9X7Q4|SC5F2A.31c from Streptomyces
coelicolor (257 aa),FASTA scores: opt: 399, E(): 1.2e-18,
(45.05% identity in 171 aa overlap); BAB52005|MLL5584 from
Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA
scores: opt: 385, E(): 9.6e-18, (41.95% identity in 174 aa
overlap); etc. Also some similarity to
3-hydroxybutyryl-CoA dehydratases e.g. P52046|CRT_CLOAB
from Clostridium acetobutylicum (261 aa),FASTA scores:
opt: 414, E(): 1.3e-19, (38.3% identity in 175 aa
overlap). And similar to other hydratases from
Mycobacterium tuberculosis e.g.
O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c probable
enoyl-CoA hydratase (257 aa), FASTA scores: opt: 365, E():
1.9e-16, (39.1% identity in 174 aa overlap). Belongs to
the enoyl-CoA hydratase/isomerase family. Note that this
homology extends across the stop codon and directly into
the next ORF MTV004.29, suggesting a possible readthrough
of the TGA stop codon."
/db_xref="EnsemblGenomes-Gn:Rv3373"
/db_xref="EnsemblGenomes-Tr:CCP46194"
/db_xref="GOA:O50402"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR018376"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:O50402"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46194.1"
/translation="MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQ
RHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGAD
IKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCI
ATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARW"
gene 3788368..3788616
/gene="echA18.1"
/gene_synonym="echA18'"
/locus_tag="Rv3374"
CDS 3788368..3788616
/codon_start=1
/transl_table=11
/gene="echA18.1"
/gene_synonym="echA18'"
/locus_tag="Rv3374"
/product="Probable enoyl-CoA hydratase (fragment) EchA18.1
(enoyl hydrase) (unsaturated acyl-CoA hydratase)
(crotonase)"
/note="Rv3374, (MTV004.32), len: 82 aa. Probable
echA18.1,enoyl-CoA hydratase C-terminus, similar to the
C-terminus of several enoyl-CoA hydratases e.g.
Q9I5I4|PA0745 from Pseudomonas aeruginosa (272 aa), FASTA
scores: opt: 123,E(): 0.13, (34.55% identity in 81 aa
overlap); P97087|CRT from Clostridium
thermosaccharolyticum (Thermoanaerobacterium
thermosaccharolyticum) (259 aa),FASTA scores: opt: 115,
E(): 0.45, (32.95% identity in 82 aa overlap);
Q9I002|PA2841 from Pseudomonas aeruginosa (263 aa), FASTA
scores: opt: 108, E(): 1.4, (30.95% identity in 84 aa
overlap); etc. Also some similarity to C-terminus of
O29956|AF0285 3-hydroxyacyl-CoA dehydrogenase from
Archaeoglobus fulgidus (658 aa), FASTA scores: opt:
116,E(): 0.81, (34.15% identity in 82 aa overlap); and
other enzymes. And similar to other hydratases from
Mycobacterium tuberculosis e.g.
O53418|ECH8_MYCTU|Rv1070c|MT1100|MTV017.23c probable
enoyl-CoA hydratase (257 aa), FASTA scores: opt: 111, E():
0.83, (36.05% identity in 86 aa overlap). This homology
extends across the upstream TGA stop codon into the
upstream ORF MTV004.28, suggesting possible readthrough of
the previous stop codon. Note that previously known as
echA18'."
/db_xref="EnsemblGenomes-Gn:Rv3374"
/db_xref="EnsemblGenomes-Tr:CCP46195"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:Q6MWX6"
/protein_id="CCP46195.1"
/translation="MVQKVVAPQDLAAATAKLVGQVCRQSAVTMRAAKVVANMHGRAL
TGADTDALIRFGVEAYEGADLREGVAAFSQGRPPKFDD"
gene 3788621..3790048
/gene="amiD"
/locus_tag="Rv3375"
CDS 3788621..3790048
/codon_start=1
/transl_table=11
/gene="amiD"
/locus_tag="Rv3375"
/product="Probable amidase AmiD (acylamidase) (acylase)"
/note="Rv3375, (MTV004.33), len: 475 aa. Probable
amiD,amidase, similar to various amidases e.g. Q53116|AMDA
enantiomerase-selective amidase from Rhodococcus sp. (462
aa), FASTA scores: opt: 1036, E(): 1.6e-54, (38.6%
identity in 464 aa overlap); Q9ZHK8|PZAA
nicotinamidase/pyrazinamidase from Mycobacterium smegmatis
(468 aa), FASTA scores: opt: 930, E(): 3.4e-48, (36.3%
identity in 463 aa overlap); Q9A551|CC2613
pyrazinamidase/nicotinamidase from Caulobacter crescentus
(464 aa), FASTA scores: opt: 841, E(): 7.1e-43, (39.45%
identity in 469 aa overlap); O69768|AMID_PSEPU amidase
from Pseudomonas putida (466 aa), FASTA scores: opt: 800,
E(): 2e-40, (33.6% identity in 467 aa overlap);
O28325|YJ54_ARCFU|AF1954 putative amidase from
Archaeoglobus fulgidu (453 aa), FASTA scores: opt:
669,E(): 1.3e-32, (30.4% identity in 467 aa overlap); etc.
Also some similarity to AMIB2|Rv1263|MT1301|MTCY50.19c
putative amidase from Mycobacterium tuberculosis (462 aa),
(31.5% identity in 466 aa overlap). Seems belong to the
amidase family."
/db_xref="EnsemblGenomes-Gn:Rv3375"
/db_xref="EnsemblGenomes-Tr:CCP46196"
/db_xref="GOA:P9WQ93"
/db_xref="InterPro:IPR000120"
/db_xref="InterPro:IPR020556"
/db_xref="InterPro:IPR023631"
/db_xref="InterPro:IPR036928"
/db_xref="UniProtKB/Swiss-Prot:P9WQ93"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46196.1"
/translation="MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTL
RRIERLDPQLKSYAFVMPETALAAARAADADIARGHYEGVLHGVPIGVKDLCYTVDAP
TAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYHPSLPTPVNPWDPT
AWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPTSMCGVTGIKPTWGRVSRHGVVEL
AASYDHVGPITRSAHDAAVLLSVIAGSDIHDPSCSAEPVPDYAADLALTRIPRVGVDW
SQTTSFDEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETAIAHADT
YPARADEYGPIMRAMIDAGHRLAAVEYQTLTERRLEFTRSLRRVFHDVDILLMPSAGI
ASPTLETMRGLGQDPELTARLAMPTAPFNVSGNPAICLPAGTTARGTPLGVQFIGREF
DEHLLVRAGHAFQQVTGYHRRRPPV"
gene 3790156..3790809
/locus_tag="Rv3376"
CDS 3790156..3790809
/codon_start=1
/transl_table=11
/locus_tag="Rv3376"
/product="Conserved hypothetical protein"
/note="Rv3376, (MTV004.34), len: 217 aa. Hypothetical
protein, similar to various bacterial proteins (notably
hydrolases) e.g. Q9RUP0|DR1344 hydrolase from Deinococcus
radiodurans (222 aa), FASTA scores: opt: 348, E():
1.8e-15,(36.75% identity in 215 aa overlap); Q9RXA1|DR0414
hydrolase (CBBY/CBBZ/GPH/YIEH family) from Deinococcus
radiodurans (155 aa), FASTA scores: opt: 233, E():
3.5e-08,(36.4% identity in 151 aa overlap); Q9X0Q9|TM1177
conserved hypothetical protein from Thermotoga maritima
(225 aa),FASTA scores: opt: 231, E(): 6.6e-08, (27.6%
identity in 221 aa overlap); Q9ABI3|CC0244 hydrolase,
haloacid dehalogenase-like from Caulobacter crescentus
(213 aa),FASTA scores: opt: 213, E(): 9.1e-07, (28.95%
identity in 221 aa overlap); BAB38231|ECS4808 putative
phosphatase from Escherichia coli strain O157:H7 (206 aa),
FASTA scores: opt: 210, E(): 1.4e-06, (26.95% identity in
193 aa overlap); etc. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3376"
/db_xref="EnsemblGenomes-Tr:CCP46197"
/db_xref="GOA:P9WMS5"
/db_xref="InterPro:IPR006439"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WMS5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46197.1"
/translation="MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGW
LNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEE
ARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEA
LGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP"
gene complement(3790848..3792353)
/locus_tag="Rv3377c"
CDS complement(3790848..3792353)
/codon_start=1
/transl_table=11
/locus_tag="Rv3377c"
/product="Halimadienyl diphosphate synthase"
/note="Rv3377c, (MTV004.35c), len: 501 aa. Halimadienyl
diphosphate synthase; similarity with various
proteins,notably cyclases involved in steroid biosynthesis
in plants and bacteria e.g. BAB52679|MLR6369 from
Rhizobium loti (Mesorhizobium loti) (516 aa), FASTA
scores: opt: 533, E(): 5.6e-27, (30.45% identity in 522 aa
overlap); Q9ZTN8 copalyl diphosphate synthase 1 from
Cucurbita maxima (Pumpkin) (Winter squash) (823 aa), FASTA
scores: opt: 484,E(): 1.2e-23, (28.35% identity in 388 aa
overlap); Q38710|AC22 abietadiene cyclase from Abies
grandis (868 aa), FASTA scores: opt: 382, E(): 5.2e-17,
(25.55% identity in 462 aa overlap); Q41771|AN1 kaurene
synthase a from Zea mays (Maize) (823 aa), FASTA scores:
opt: 377, E(): 1.1e-16, (29.75% identity in 390 aa
overlap); Q9AJE4 diterpene cyclase-1 from Kitasatospora
griseola (Streptomyces griseolosporeus) (499 aa), FASTA
scores: opt: 336, E(): 3.2e-14, (27.5% identity in 513 aa
overlap); Q9SAU6 E-alpha-bisabolene synthase (fragment)
from Abies grandis (782 aa), FASTA scores: opt: 317, E():
7.8e-13,(25.25% identity in 479 aa overlap); etc. Note
that this and the upstream ORF MTV004.36c have a
significantly lower GC bias than the rest of the genome.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007). Cofactor: Mg2+."
/db_xref="EnsemblGenomes-Gn:Rv3377c"
/db_xref="EnsemblGenomes-Tr:CCP46198"
/db_xref="GOA:O50406"
/db_xref="InterPro:IPR001330"
/db_xref="InterPro:IPR008930"
/db_xref="InterPro:IPR032696"
/db_xref="UniProtKB/Swiss-Prot:O50406"
/protein_id="CCP46198.1"
/translation="METFRTLLAKAALGNGISSTAYDTAWVAKLGQLDDELSDLALNW
LCERQLPDGSWGAEFPFCYEDRLLSTLAAMISLTSNKHRRRRAAQVEKGLLALKNLTS
GAFEGPQLDIKDATVGFELIAPTLMAEAARLGLAICHEESILGELVGVREQKLRKLGG
SKINKHITAAFSVELAGQDGVGMLDVDNLQETNGSVKYSPSASAYFALHVKPGDKRAL
AYISSIIQAGDGGAPAFYQAEIFEIVWSLWNLSRTDIDLSDPEIVRTYLPYLDHVEQH
WVRGRGVGWTGNSTLEDCDTTSVAYDVLSKFGRSPDIGAVLQFEDADWFRTYFHEVGP
SISTNVHVLGALKQAGYDKCHPRVRKVLEFIRSSKEPGRFCWRDKWHRSAYYTTAHLI
CAASNYDDALCSDAIGWILNTQRPDGSWGFFDGQATAEETAYCIQALAHWQRHSGTSL
SAQISRAGGWLSQHCEPPYAPLWIAKTLYCSATVVKAAILSALRLVDESNQ"
gene complement(3792358..3793248)
/locus_tag="Rv3378c"
CDS complement(3792358..3793248)
/codon_start=1
/transl_table=11
/locus_tag="Rv3378c"
/product="Diterpene synthase"
/note="Rv3378c, (MTV004.36c), len: 296 aa. Diterpene
synthase. Note that this ORF and the downstream ORF
MTV004.35c have a significantly lower GC bias than the
rest of the genome. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007). Cofactor: Mg2+."
/db_xref="EnsemblGenomes-Gn:Rv3378c"
/db_xref="EnsemblGenomes-Tr:CCP46199"
/db_xref="GOA:P9WJ61"
/db_xref="InterPro:IPR036424"
/db_xref="PDB:3WQK"
/db_xref="PDB:3WQL"
/db_xref="PDB:3WQM"
/db_xref="PDB:3WQN"
/db_xref="PDB:4CMV"
/db_xref="PDB:4CMW"
/db_xref="PDB:4CMX"
/db_xref="PDB:4KT8"
/db_xref="UniProtKB/Swiss-Prot:P9WJ61"
/protein_id="CCP46199.1"
/translation="MNLVSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLEC
NPQYDDYQQAALRQSIRILKMLFEHGIETVISPIFSDDLLDRGDRYIVQALEGMALLA
NDEEILSFYKEHEVHVLFYGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTEHRLCFGV
FGNDAAESVAQFSISWNETHGKPPTRREIIEGYYGEYVDKADMFIGFGRFSTFDFPLL
SSGKTSLYFTVAPSYYMTETTLRRILYDHIYLRHFRPKPDYSAMSADQLNVLRNRYRA
QPDRVFGVGCVHDGIWFAEG"
gene complement(3793257..3794867)
/gene="dxs2"
/locus_tag="Rv3379c"
CDS complement(3793257..3794867)
/codon_start=1
/transl_table=11
/gene="dxs2"
/locus_tag="Rv3379c"
/product="Probable 1-deoxy-D-xylulose 5-phosphate synthase
Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase)
(DXPS)"
/note="Rv3379c, (MTV004.37c), len: 536 aa. Probable
dxs2,1-deoxy-D-xylulose 5-phosphate synthase, similar to
many e.g. Q9F1V2|DXS from Kitasatospora griseola
(Streptomyces griseolosporeus) (649 aa), FASTA scores:
opt: 1274, E(): 5.4e-71, (50.9% identity in 570 aa
overlap); Q9X7W3|DXS_STRCO|SC6A5.17 from Streptomyces
coelicolor (656 aa), FASTA scores: opt: 1248, E():
2.2e-69, (50.55% identity in 568 aa overlap);
Q9RBN6|DXS_STRC1 from Streptomyces sp. strain CL190 (631
aa), FASTA scores: opt: 1237, E(): 1e-68, (49.1% identity
in 570 aa overlap); Q50000|DXS_MYCLE|TKTB|ML1038 from
Mycobacterium leprae (643 aa), FASTA scores: opt: 1215,
E(): 2.4e-67, (46.75% identity in 571 aa overlap);
Q9R6S7|DXS_SYNLE from Synechococcus leopoliensis (636 aa),
FASTA scores: opt: 849, E(): 8.9e-45, (38.55% identity in
550 aa overlap); etc. Also similar to
O07184|DXS_MYCTU|Rv2682c|MT2756|MTCY05A6.03c from
Mycobacterium tuberculosis (638 aa), FASTA scores: opt:
1226, E(): 4.9e-68, (48.9% identity in 558 aa overlap).
Belongs to the transketolase family, DXS subfamily.
Cofactor: thiamine pyrophosphate (by similarity). Note
that the N-terminus of this putative protein appears to
have been interrupted by the adjacent IS6110 element."
/db_xref="EnsemblGenomes-Gn:Rv3379c"
/db_xref="EnsemblGenomes-Tr:CCP46200"
/db_xref="GOA:O50408"
/db_xref="InterPro:IPR005475"
/db_xref="InterPro:IPR005477"
/db_xref="InterPro:IPR009014"
/db_xref="InterPro:IPR020826"
/db_xref="InterPro:IPR029061"
/db_xref="InterPro:IPR033248"
/db_xref="UniProtKB/TrEMBL:O50408"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46200.1"
/translation="MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWV
ENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVI
VVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVL
RKAAAAARPVVVHAVTSKGRGYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVF
EDEIARIADDRSDVVGLTAAMRLPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAA
GTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLA
CVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTP
PPHWRPDVLLVAVGAMSRPCMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRI
TVCVEDAIADVGIGAHLSHHIGRTHPRTRTYTLGLPPAYIPHASRDHILSSHGLTGPA
IRIRCKSLLNALHEVPGPEDHPDSGDSY"
mobile_element 3795058..3796412
/mobile_element_type="insertion sequence:IS6110-15"
/note="IS6110-15, len: 1355 nt. Insertion sequence
IS6110."
repeat_region 3795058..3795085
/note="28 bp inverted repeat at the left end of
IS6110,TGAACCGCCCCGGTGAGTCCGGAGACTC"
gene complement(3795100..>3796086)
/locus_tag="Rv3380c"
CDS complement(3795100..>3796086)
/codon_start=1
/transl_table=11
/locus_tag="Rv3380c"
/product="Probable transposase"
/note="Rv3380c, (MTV004.38c), len: 328 aa. Probable
transposase subunit for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv3380c and Rv3381c, the
sequence UUUUAAAG (directly upstream of Rv3380c) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (+ 34
aa)."
/db_xref="EnsemblGenomes-Gn:Rv3380c"
/db_xref="EnsemblGenomes-Tr:CCP46201"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP46201.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
gene complement(3796035..3796361)
/locus_tag="Rv3381c"
CDS complement(3796035..3796361)
/codon_start=1
/transl_table=11
/locus_tag="Rv3381c"
/product="Probable transposase for insertion sequence
element IS6110 (fragment)"
/note="Rv3381c, (MTV004.39c), len: 108 aa. Putative
Transposase for IS6110 (fragment). Identical to many other
M. tuberculosis IS6110 transposase subunits. The
transposase described here may be made by a frame shifting
mechanism during translation that fuses Rv3380c and
Rv3381c, the sequence UUUUAAAG (directly upstream of
Rv3380c) maybe responsible for such a frameshifting event
(see McAdam et al., 1990)."
/db_xref="EnsemblGenomes-Gn:Rv3381c"
/db_xref="EnsemblGenomes-Tr:CCP46202"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP46202.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
repeat_region complement(3796385..3796412)
/note="28 bp inverted repeat at the right end of
IS6110,TGAACCGCCCCGGCATGTCCGGAGACTC"
gene complement(3796448..3797437)
/gene="lytB1"
/locus_tag="Rv3382c"
CDS complement(3796448..3797437)
/codon_start=1
/transl_table=11
/gene="lytB1"
/locus_tag="Rv3382c"
/product="Probable LYTB-related protein LytB1"
/note="Rv3382c, (MTV004.40c), len: 329 aa. Probable
lytB1,lytB-related protein, highly similar to many e.g.
Q9HVM7|LYTB_PSEAE|PA4557 from Pseudomonas aeruginosa (314
aa), FASTA scores: opt: 1048, E(): 2e-55, (53.2% identity
in 314 aa overlap); Q9JR39|LYTB|NMA0624|NMB1831 from
Neisseria meningitidis (serogroup a and B) (322 aa), FASTA
scores: opt: 1041, E(): 5.4e-55, (52.25% identity in 312
aa overlap); P22565|LYTB_ECOLI|B0029 from Escherichia coli
strain K12 (316 aa), FASTA scores: opt: 1013, E():
2.5e-53,(51.45% identity in 311 aa overlap) (for more
information about lytB protein, see citation below);
Q9X781|LYTB_MYCLE|LYTB2|ML1938|MLCB1222.06c from
Mycobacterium leprae (332 aa), FASTA scores: opt: 979,
E(): 2.8e-51, (51.3% identity in 312 aa overlap); etc.
Also similar to Q9PAS9|XF2416 drug tolerance protein from
Xylella fastidiosa (316 aa), FASTA scores: opt: 1043, E():
4.1e-55, (53.65% identity in 315 aa overlap). And similar
to O53458|Rv1110|LYTB2|MTV017.63 from Mycobacterium
tuberculosis (335 aa), FASTA scores: opt: 975, E():
4.9e-51, (51.3% identity in 312 aa overlap). Belongs to
the LytB family."
/db_xref="EnsemblGenomes-Gn:Rv3382c"
/db_xref="EnsemblGenomes-Tr:CCP46203"
/db_xref="GOA:P9WKF9"
/db_xref="InterPro:IPR003451"
/db_xref="UniProtKB/Swiss-Prot:P9WKF9"
/protein_id="CCP46203.1"
/translation="MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLD
VAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVR
AGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTL
LVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDALRARFPTLGQPPSEDICYAT
TNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSS
VSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ"
gene complement(3797437..3798489)
/gene="idsB"
/locus_tag="Rv3383c"
CDS complement(3797437..3798489)
/codon_start=1
/transl_table=11
/gene="idsB"
/locus_tag="Rv3383c"
/product="Possible polyprenyl synthetase IdsB (polyprenyl
transferase) (polyprenyl diphosphate synthase)"
/note="Rv3383c, (MTV004.41c), len: 350 aa. Possible
idsB,polyprenyl transferase (polyprenyl diphosphate
synthase) ,similar to many prenyltransferases involved in
lipid biosynthesis e.g. Q9RGW1|GTR geranyl transferase
from Streptomyces coelicolor (386 aa), FASTA scores: opt:
908,E(): 3.7e-50, (48.8/% identity in 334 aa overlap);
Q9KWG0|GGDPS geranyl geranyl diphosphate synthase from
Kitasatospora griseola (Streptomyces griseolosporeus) (348
aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity
in 347 aa overlap); Q9X7V8|SC6A5.12 putative polyprenyl
synthetase from Streptomyces coelicolor (378 aa), FASTA
scores: opt: 779, E(): 5.3e-42, (44.45% identity in 324 aa
overlap); Q9S5E9 farnesyl, geranylgeranyl,
geranylfarnesyl,hexaprenyl, heptaprenyl diphosphate
synthase (self-HEPPS) from Synechococcus elongatus (324
aa), FASTA scores: opt: 563, E(): 2.3e-28, (39.85%
identity in 241 aa overlap) (see citation below);
O26156|IDSA_METTH|MTH50 bifunctional short chain isoprenyl
diphosphate synthase [includes: farnesyl pyrophosphate
synthetase (FPP synthetase) (dimethylallyltransferase) and
geranyltranstransferase] from Methanobacterium
thermoautotrophicum (325 aa), FASTA scores: opt: 540, E():
6.5e-27, (35.75% identity in 319 aa overlap);
P95999|GGPP_SULSO|GDS|GDS-1|SSO0061|C05010|C05_049
geranylgeranyl pyrophosphate synthetase (GGPP synthetase)
(GGPS) [includes: dimethylallyltransferase and
geranyltranstransferase and farnesyltranstransferase] from
Sulfolobus solfataricus (332 aa), FASTA scores: opt:
511,E(): 4.5e-25 (36.9% identity in 244 aa overlap); etc.
Also similar to Q50727|GGPP_MYCTU|Rv3398c|MT3506|MTCY78.30
probable multifunctional geranylgeranyl pyrophosphate
synthetase [includes: dimethylallyltransferase;
geranyltranstransferase; farnesyltranstransferase] from
Mycobacterium tuberculosis (359 aa), FASTA scores: opt:
687, E(): 3.4e-36, (39.1% identity in 325 aa overlap).
Contains PS00723 Polyprenyl synthetases signature 1.
Belongs to the FPP/GGPP synthetases family."
/db_xref="EnsemblGenomes-Gn:Rv3383c"
/db_xref="EnsemblGenomes-Tr:CCP46204"
/db_xref="GOA:O50410"
/db_xref="InterPro:IPR000092"
/db_xref="InterPro:IPR008949"
/db_xref="InterPro:IPR033749"
/db_xref="UniProtKB/TrEMBL:O50410"
/inference="protein motif:PROSITE:PS00723"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46204.1"
/translation="MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMRE
PLATMAGYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSAAVELVH
NFTLLHDDVMDGDATRRGRPTVWSVWGVGVAILLGDALHATAVRILTGLTDECVAVRA
IRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKTAALTGCCCALGALVANAD
DATIAALERFGHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSR
SEAATELAALYQAPAAMTASDVERATALVKVAGGGHVAQRCADERIQAAIAALPDAVR
SPDLIALSQLICRREC"
gene complement(3799243..3799635)
/gene="vapC46"
/locus_tag="Rv3384c"
CDS complement(3799243..3799635)
/codon_start=1
/transl_table=11
/gene="vapC46"
/locus_tag="Rv3384c"
/product="Possible toxin VapC46. Contains PIN domain."
/note="Rv3384c, (MTV004.42c), len: 130 aa. Possible
vapC46,toxin, part of toxin-antitoxin (TA) operon with
Rv3385c,contains PIN domain, see Arcus et al. 2005.
Similar to others in Mycobacterium tuberculosis e.g.
P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA scores: opt:
266, E(): 1.6e-10, (43.1% identity in 130 aa overlap); and
Q50717|YY08_MYCTU|Rv3408|MTCY78.20c (136 aa), FASTA
scores: opt: 243, E(): 4.8e-09, (35.1% identity in 131 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3384c"
/db_xref="EnsemblGenomes-Tr:CCP46205"
/db_xref="GOA:O50411"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:O50411"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46205.1"
/translation="MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEV
MRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAGGLLPFELRTLDAIHLATAQRLG
VDLGRLCTYDDRMRDAAKTLGMAVIAPS"
gene complement(3799635..3799943)
/gene="vapB46"
/locus_tag="Rv3385c"
CDS complement(3799635..3799943)
/codon_start=1
/transl_table=11
/gene="vapB46"
/locus_tag="Rv3385c"
/product="Possible antitoxin VapB46"
/note="Rv3385c, (MTV004.43c), len: 102 aa. Possible
vapB46,antitoxin, part of toxin-antitoxin (TA) operon with
Rv3386c, see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis hypothetical proteins e.g.
Q50718|Y09M_MYCTU|MTCY78.21c|Rv3407|MT3515 (99 aa), FASTA
scores: opt: 155, E(): 0.001, (41.05% identity in 78 aa
overlap); O07782|Rv0596c|MTCY19H5.26 (85 aa), FASTA
scores: opt: 136, E(): 0.016, (39.45% identity in 71 aa
overlap); P96916|Rv0626|MTCY20H10.07 (86 aa), FASTA
scores: opt: 130,E(): 0.04, (51.2% identity in 41 aa
overlap); etc. Also similar to prevent host death (PHD)
proteins e.g. CAA66834|PHD from Escherichia coli (73 aa),
FASTA scores: opt: 113, E(): 0.45, (39.4% identity in 66
aa overlap); and Q06253|PHD_BPP1 from Bacteriophage P1 (73
aa), FASTA scores: opt: 113, E(): 0.45, (39.4% identity in
66 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3385c"
/db_xref="EnsemblGenomes-Tr:CCP46206"
/db_xref="GOA:P9WF13"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:P9WF13"
/protein_id="CCP46206.1"
/translation="MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGR
PVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPSVTLARLREHER
"
mobile_element 3799987..3801554
/mobile_element_type="insertion sequence:IS1560-2"
/note="IS1560-2, len: 1568 nt. Possible Insertion sequence
element IS_1560. Second copy in MTCY10G2 from 11273 to
12919."
repeat_region 3799987..3800011
/note="25 bp inverted repeat at the right end of putative
IS1560, TAATTACTAGGACCTGAAAAAGTCG"
gene 3800092..3800796
/locus_tag="Rv3386"
CDS 3800092..3800796
/codon_start=1
/transl_table=11
/locus_tag="Rv3386"
/product="Possible transposase"
/note="Rv3386, (MTV004.44), len: 234 aa. Possible
transposase, showing very weak similarity to several is
element transposases. Highly similar (but shorter) to
P963659|MTCY10G2_13|Rv1036c from Mycobacterium
tuberculosis (112 aa), FASTA scores: opt: 507, E():
8.3e-25, (83.9% identity in 87 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3386"
/db_xref="EnsemblGenomes-Tr:CCP46207"
/db_xref="GOA:O50413"
/db_xref="InterPro:IPR008490"
/db_xref="UniProtKB/TrEMBL:O50413"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46207.1"
/translation="MFRTVGDQASLWESVLPEELRRLPEELARVDALLDDSAFFCPFV
PFFDPRMGRPSIPMETYLRLMFLKFRYRLGYESLCREVTDSITWRRFCRIPLEGSVPH
PTTLMKLTTRCGEDAVAGLNEALLAKAASEKLLRTNKVRADTTVVEGDVGYPTDTGLL
AKAVGSMARTVARIKAADAGSAPLGGSSGPRDRLQAAVTRRAATRSGAGLRAPDHRGA
SRDRRAGADRGCRGGT"
gene 3800786..3801463
/locus_tag="Rv3387"
CDS 3800786..3801463
/codon_start=1
/transl_table=11
/locus_tag="Rv3387"
/product="Possible transposase"
/note="Rv3387, (MTV004.45), len: 225 aa. Possible
transposase, showing very weak similarity to other is
element proteins, and similar to various hypothetical
proteins."
/db_xref="EnsemblGenomes-Gn:Rv3387"
/db_xref="EnsemblGenomes-Tr:CCP46208"
/db_xref="GOA:O50414"
/db_xref="InterPro:IPR002559"
/db_xref="UniProtKB/TrEMBL:O50414"
/protein_id="CCP46208.1"
/translation="MVRNAQRAVRRASGRRKAWLRQAINHLEKLIGRTERVVDQARSR
LAGVMPDSSSRLVSLHDADARPIRKGRLGKPVEFGYKAQVVDNADGVILDHSVELGNP
ADAPQLAPAIERISRRTGRPPRAVTADRGCGDASVEDDLHQLGVRNVAIPRKSKPSAT
RRAFEHRRAFRDKIKWRTGSEGRINHLKRSYGWNRTELTGITGARTWCGHGVFAHNLV
KISTLAA"
repeat_region complement(3801530..3801554)
/note="25 bp inverted repeat at the right end of putative
IS1560, TAATTACTAAGACCTGAAAAAGTCG"
gene 3801653..3803848
/gene="PE_PGRS52"
/locus_tag="Rv3388"
CDS 3801653..3803848
/codon_start=1
/transl_table=11
/gene="PE_PGRS52"
/locus_tag="Rv3388"
/product="PE-PGRS family protein PE_PGRS52"
/note="Rv3388, (MTV004.46), len: 731 aa. PE_PGRS52, Member
of the M. tuberculosis PE family, PGRS subfamily of
gly-rich proteins (see citation below), similar to many
PE-family proteins from Mycobacterium tuberculosis strains
H37Rv and CDC1551 e.g. O53553|YZ08_MYCTU|RV3508|MTV023.15
(1901 aa), FASTA scores: opt: 2380, E(): 3.6e-87, (53.8%
identity in 773 aa overlap); and MTV023_21,
MTV023_18,MTV023_14, MTV039_16, MTCY441_4. Predicted to be
an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3388"
/db_xref="EnsemblGenomes-Tr:CCP46209"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MWX5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46209.1"
/translation="MSFVIANPEMLAAAATDLAGIRSAISAATAAAAAPTIQVAAAGA
DEVSLAISALFGQHAQAYQALSAQATIFHDQFVQALTSGGNLYAAAESHTVEQMVLNA
INAPTQTLFGRPLIGDGANGTAENPDGQNGGLLFGNGGNGFTQTTAGVAGGNGGSAGL
IGNGGAGGGGGAGAAGGLGGNGGWLYGNGGAGGIGGAGTGTGGHGGAGGAGGRAWLWG
TGGAGGAGGDGGWLFGDGGAGGTGGNGGSGFNSLTSSVGGAGGAGGHAGLFGAGGTGG
TGGIGGQNTETGPAASNGGAGGAGGGGGYLVGDGGAGGTGGAGGKNSSGGATLTGGTG
GTGGAGGAAGWLYGSGGAGGAGGAGGLNNAGGATGGTGGTGGAGGSGAWLYGNGGAAG
AGGNGGNNTSAGTGGVGASGGTGGNAGLIGAGGHGGAGGAGGNQTGGVGNGGAGGNGG
AGGAGGQLYGNGGDGGNGGAGGANIAGGNGSDGGAAGHGGAGGSARLIGAGGHGGDGG
AGGNTAGRRADAIAGTGGDGGNGGNGGLLSGNAGAGGHGGAGGSSTATTTTGTPPTGA
TGGNGGNGGAGGTAGFTGSGGIGGNGGAGGTGGNAGVALSVGSTGGLGGNGGSGGLGG
GGGSLFGNGGAGGVGATGGNGGSGIGPASVGGNGGKGGVGAAGGLAGQIGNGGSGGSG
GAGGNGGTGDTAGNGGNGGAGAVGGNAQLIGNGGNGGGGGNGGTGADGT"
gene complement(3803919..3804791)
/gene="htdY"
/locus_tag="Rv3389c"
CDS complement(3803919..3804791)
/codon_start=1
/transl_table=11
/gene="htdY"
/locus_tag="Rv3389c"
/product="Probable 3-hydroxyacyl-thioester dehydratase
HtdY"
/note="Rv3389c, (MTV004.47c), len: 290 aa. Probable
htdY,3-hydroxyacyl-thioester dehydratase (See Gurvitz et
al.,2009), shows structural similarity to six others in
Mycobacterium tuberculosis (see Castell et al., 2005)
especially Rv3538. Also shows similarity to members of
short-chain dehydrogenases/reductases (SDR) family e.g.
Q9L009|SCC30.12c putative dehydrogenase from Streptomyces
coelicolor (333 aa), FASTA scores: opt: 602, E():
2.7e-30,(40.35% identity in 305 aa overlap);
Q19058|E04F6.3 hydratase-dehydrogenase-epimerase from
Caenorhabditis elegans (298 aa), FASTA scores: opt: 573,
E(): 1.6e-28,(41.0% identity in 266 aa overlap);
Q9LBK1|PHAJ2|PA1018 (R)-specific enoyl-CoA hydratase from
Pseudomonas aeruginosa (288 aa), FASTA scores: opt: 601,
E(): 2.7e-30,(40.5% identity in 294 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3389c"
/db_xref="EnsemblGenomes-Tr:CCP46210"
/db_xref="InterPro:IPR002539"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR039569"
/db_xref="PDB:3KHP"
/db_xref="UniProtKB/TrEMBL:I6YBZ8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46210.1"
/translation="MAIDPNSIGAVTEPMLFEWTDRDTLLYAIGVGAGTGDLAFTTEN
SHGIDQQVLPTYAVICCPAFGAAAKVGTFNPAALLHGSQGIRLHAPLPAAGKLSVVTE
VADIQDKGEGKNAIVVLRGRGCDPESGSLVAETLTTLVLRGQGGFGGARGERPAAPEF
PDRHPDARIDMPTREDQALIYRLSGDRNPLHSDPWFATQLAGFPKPILHGLCTYGVAG
RALVAELGGGVAANITSIAARFTKPVFPGETLSTVIWRTEPGRAVFRTEVAGSDGAEA
RVVLDDGAVEYVAG"
gene 3804865..3805575
/gene="lpqD"
/locus_tag="Rv3390"
CDS 3804865..3805575
/codon_start=1
/transl_table=11
/gene="lpqD"
/locus_tag="Rv3390"
/product="Probable conserved lipoprotein LpqD"
/note="Rv3390, (MTV004.48), len: 236 aa. Probable lpqD, a
conserved lipoprotein with some similarity to various
bacterial proteins e.g. Q9F3Q7|SC10F4.03 putative
isomerase from Streptomyces coelicolor (224 aa), FASTA
scores: opt: 416, E(): 2.5e-18, (33.0% identity in 197 aa
overlap); Q9ZAX0|PGM 2,3-PDG dependent phosphoglycerate
mutase from Amycolatopsis methanolica (205 aa), FASTA
scores: opt: 314,E(): 3.7e-12, (28.55% identity in 203 aa
overlap); P73454|SLR1748 hypothetical 24.2 KDA protein
from Synechocystis sp. strain PCC 6803 (214 aa), FASTA
scores: opt: 201, E(): 2.8e-05, (23.8% identity in 189 aa
overlap); etc. Also similar to Mycobacterium tuberculosis
hypothetical proteins e.g. O53817|Rv0754|MTV041.28
PGRS-family protein (584 aa), FASTA scores: opt: 219, E():
5.1e-06, (39.8% identity in 226 aa overlap). Contains
signal sequence and appropriately positioned PS00013
Prokaryotic membrane lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3390"
/db_xref="EnsemblGenomes-Tr:CCP46211"
/db_xref="GOA:O50416"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="UniProtKB/TrEMBL:O50416"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46211.1"
/translation="MAKRTPVRKACTVLAVLAATLLLGACGGPTQPRSITLTFIRNAQ
SQANADGIIDTDMPGSGLSADGKAEAQQVAHQVSRRDVDSIYSSPMAADQQTAGPLAG
ELGKQVEILPGLQAINAGWFNGKPESMANSTYMLAPADWLAGDVHNTIPGSISGTEFN
SQFSAAVRKIYDSGHNTPVVFSQGVAIMIWTLMNARNSRDSLLTTHPLPNIGRVVITG
NPVTGWRLVEWDGIRNFT"
gene 3805621..3807573
/gene="acrA1"
/locus_tag="Rv3391"
CDS 3805621..3807573
/codon_start=1
/transl_table=11
/gene="acrA1"
/locus_tag="Rv3391"
/product="Possible multi-functional enzyme with
acyl-CoA-reductase activity AcrA1"
/note="Rv3391, (MTV004.49), len: 650 aa. Possible
acrA1,multi functional protein with fatty acyl-CoA
reductase activity in C-terminal part. Indeed C-terminal
part highly similar to P94129|ACR1 fatty acyl-CoA
reductase from Acinetobacter calcoaceticus (295 aa), FASTA
scores: opt: 767, E(): 1.4e-36, (45.4% identity in 260 aa
overlap); and similar to other oxidoreductases
dehydrogenases/reductases e.g. Q9Y3A1 CGI-93 protein
(similarity with SDR family) from Homo sapiens (Human)
(291 aa), FASTA scores: opt: 363,E(): 1.5e-13, (38.65%
identity in 194 aa overlap); Q9L146|SC6D11.09 putative
oxidoreductase (similarity with SDR family) from
Streptomyces coelicolor (343 aa), FASTA scores: opt: 346,
E(): 1.6e-12, (30.4% identity in 283 aa overlap);
Q9HSR4|YUSZ1|VNG0115G oxidoreductase from Halobacterium
sp. strain NRC-1 (260 aa), FASTA scores: opt: 338, E():
3.7e-12, (33.85% identity in 248 aa overlap); etc.
C-terminus also similar to Mycobacterium tuberculosis
proteins Q10783|YF43_MYCTU|Rv1543|MTCY48.22c putative
oxidoreductase (341 aa), FASTA scores: opt: 787, E():
1.2e-37, (39.8% identity in 319 aa overlap);
O06413|Rv0547c|MTCY25D10.26c hypothetical 31.8 KDA protein
(294 aa), FASTA scores: opt: 565, E(): 4.7e-25, (36.8%
identity in 242 aa overlap); O53398|Rv1050|MTV017.03
oxidoreductase (SDR family) (301 aa), FASTA scores: opt:
436, E(): 1.1e-17, (32.2% identity in 292 aa overlap).
N-terminus (aa 1-320) is similar to P37693|HETM_ANASP
polyketide synthase hetM from Anabaena sp. (506 aa), FASTA
scores: opt: 188, E(): 1.3e-07, (27.7% identity in 361 aa
overlap); so certainly a multi-domain enzyme. Seems to
belong to the short-chain dehydrogenases/reductases (SDR)
family. Note that this ORF corresponds to the gene
ORF2|Q11197 (see Yuan et al., 1995), but longer 266 aa,
due to use of a more upstream start site."
/db_xref="EnsemblGenomes-Gn:Rv3391"
/db_xref="EnsemblGenomes-Tr:CCP46212"
/db_xref="GOA:O50417"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR013120"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O50417"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46212.1"
/translation="MRYVVTGGTGFIGRHVVSRLLDGRPEARLWALVRRQSLSRFERL
AGQWGDRVRPLVGDLTELELSERTIAELGDIDHVLHCAAVHDTTWADATRAVIELAAR
LDATFHHVSSIAVAGDFAGHYTEADFDVGQRLPTPYHRMTFEAERLVRSTPGLRYRIY
RPAVVVGDSRTGEMDTIDGPYYLFGVLAKLAVLPSFTPMLLPDIGRTNIVPVDYVADA
LVALMHADGRDGQTFHLTAPTAIGLRGIYRGIAGAAGLPPLLGTLPGFVAAPVLNARG
RAKVLRNMAATQLGIPAEIFDVVGCAPTFTSDTTREALRGTGIHVPEFATYAPGLWRY
WAEHLDPDRARRNDPLLGRHVIITGASSGIGRASAIAVAKRGATVFALARNGNALDEL
VTEIRAHGGQAHAFTCDVTDSASVEHTVKDILGRFDHVDYLVNNAGRSIRRSVVNSTD
RLHDYERVMAVNYFGAVRMVLALLPHWRERRFGHVVNVSSAGVQARNPKYSSYLPTKA
ALDAFADVVASETLSDHITFTNIHMPLVATPMIVPSRRLNPVRAISAERAAAMVIRGL
VEKPARIDTPLGTLAEAGNYVAPRLSRRILHQLYLGYPDSAAAQGISRPDADRPPAPR
RPRRSARAGVPRPLRRLGRLVPGVHW"
gene complement(3807574..3808437)
/gene="cmaA1"
/locus_tag="Rv3392c"
CDS complement(3807574..3808437)
/codon_start=1
/transl_table=11
/gene="cmaA1"
/locus_tag="Rv3392c"
/product="Cyclopropane-fatty-acyl-phospholipid synthase 1
CmaA1 (cyclopropane fatty acid synthase) (CFA synthase)
(cyclopropane mycolic acid synthase 1)"
/note="Rv3392c, (MTV004.50), len: 287 aa.
CmaA1,cyclopropane mycolic acid synthase 1, characterized
in 1995 as CFA1_MYCTU|Q11195|CMAA1|CMA1
cyclopropane-fatty-acyl-phospholipid synthase 1 (see
citations below). Highly similar to Mycobacterium
tuberculosis proteins MTCY20H10.23c (58.7% identity in 286
aa overlap); MTCY20H10.24c (68.6% identity); MTCY20H10.25c
(73.5% identity); MTCY20H10.26c (57.0% identity); and
MTCY20G9.30c (55.7% identity). Also highly similar to
Q9CBK3|MMAA4|ML1903 methyl mycolic acid synthases from
Mycobacterium leprae (298 aa), FASTA scores: opt:
1098,E(): 1e-63, (57.0% identity in 286 aa overlap).
Equivalent to AAK44898|MT0672 from Mycobacterium
tuberculosis strain CDC1551 (317 aa) but shorter 30 aa and
with some differences in residues between the proteins."
/db_xref="EnsemblGenomes-Gn:Rv3392c"
/db_xref="EnsemblGenomes-Tr:CCP46213"
/db_xref="GOA:P9WPB7"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="PDB:1KP9"
/db_xref="PDB:1KPG"
/db_xref="PDB:1KPH"
/db_xref="UniProtKB/Swiss-Prot:P9WPB7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46213.1"
/translation="MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMT
LQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANH
VQQLVANSENLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPA
DGVMLLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASAN
GFTVTRVQSLQPHYAKTLDLWSAALQANKGQAIALQSEEVYERYMKYLTGCAEMFRIG
YIDVNQFTCQK"
gene 3808461..3809387
/gene="iunH"
/locus_tag="Rv3393"
CDS 3808461..3809387
/codon_start=1
/transl_table=11
/gene="iunH"
/locus_tag="Rv3393"
/product="Probable nucleoside hydrolase IunH (purine
nucleosidase)"
/note="Rv3393, (MTV004.51), len: 308 aa. Probable
iunH,nucleoside hydrolase, similar to others e.g.
Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA
scores: opt: 497, E(): 6e-24, (34.3% identity in 312 aa
overlap); Q27546|IUNH_CRIFA from Crithidia fasciculata
(314 aa),FASTA scores: opt: 475, E(): 1.4e-22, (31.45%
identity in 318 aa overlap); Q9CK67|IUNH from Pasteurella
multocida (310 aa), FASTA scores: opt: 464, E(): 6.9e-22,
(30.9% identity in 314 aa overlap); Q9A549|CC2615 from
Caulobacter crescentus (323 aa), FASTA scores: opt: 464,
E(): 7.2e-22,(37.85% identity in 280 aa overlap); etc.
Note that also similar to BAB34113|ECS0690 (alias
AAG54985|YBEK) putative tRNA synthetase from Escherichia
coli strain O157:H7 (311 aa), FASTA scores: opt: 483, E():
4.5e-23, (33.0% identity in 315 aa overlap). The active
site histidine is conserved."
/db_xref="EnsemblGenomes-Gn:Rv3393"
/db_xref="EnsemblGenomes-Tr:CCP46214"
/db_xref="GOA:O50418"
/db_xref="InterPro:IPR001910"
/db_xref="InterPro:IPR023186"
/db_xref="InterPro:IPR036452"
/db_xref="UniProtKB/TrEMBL:O50418"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46214.1"
/translation="MSVVFADVDTGIDDALAVIYLLASPDADLVGIASTGGNIAVGQV
CANNLSLLELCGAADIPVSKGADEPLGGRWPDHPKFHGPKGIGYAELPASNRRLTDYD
ATTAWIAAAHSHAGDLIGLVTGPLTNLALALRAEPALPRLLRRLVIMGGMFDGQPITE
WNIRVDPEAASEVFTAWAGQRQLPIVCGLDLTRRVAMTPDILARLASVCGSSPVMRVI
EDALRFYFESHEARGHGYLAYMHDPLAAAVAMDPELLTTRTATVDVDPTGATVTDWSG
KRNPNARIGMSVDPAVFFDRFVERIGRFARRT"
gene complement(3809442..3811025)
/locus_tag="Rv3394c"
CDS complement(3809442..3811025)
/codon_start=1
/transl_table=11
/locus_tag="Rv3394c"
/product="Conserved hypothetical protein"
/note="Rv3394c, (MTV004.52c), len: 527 aa. Hypothetical
protein, with some similarity to various bacterial
proteins e.g. BAB51085|MLR4427 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (545 aa), FASTA
scores: opt: 267,E(): 2.8e-08, (26.5% identity in 509 aa
overlap); BAB48362|MLR0866 DNA damage inducible protein P
from Rhizobium loti (Mesorhizobium loti) (438 aa), FASTA
scores: opt: 245, E(): 4.6e-07, (25.5% identity in 290 aa
overlap); Q9S292|SCI11.27c hypothetical protein from
Streptomyces coelicolor (322 aa), FASTA scores: opt: 202,
E(): 0.00012,(28.5% identity in 323 aa overlap); etc. Also
similarity with P95102|DINP|RV3056|MTCY22D7.25c
hypothetical protein from Mycobacterium tuberculosis (346
aa), FASTA scores: opt: 211, E(): 3.9e-05, (26.45%
identity in 306 aa overlap). Equivalent to AAK47838 from
Mycobacterium tuberculosis strain CDC1551 (492 aa) but
longer 35 aa."
/db_xref="EnsemblGenomes-Gn:Rv3394c"
/db_xref="EnsemblGenomes-Tr:CCP46215"
/db_xref="GOA:O50419"
/db_xref="InterPro:IPR001126"
/db_xref="UniProtKB/TrEMBL:O50419"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46215.1"
/translation="MMASARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACS
ATARAAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAELLRPG
LLVLPVRGPARFFGSEQMAAERLIDAVAAAGAECQVGIADRLSTAVFAARAGRIVEPG
GDARFLSLLSIRQLATEPSLSGPGRDDLTDLLWRMGIRTIGQFAALSRTDVASRFGAD
AVAAHRFARGEPERAPCGREPPPDLAAELACDPPIDRVDAAAFAGRSLAAELHRALMA
AGVGCTRLAIHAVTANGEERSRVWRCAEPLTEDATADRVRWQLDGWLNNRNARDRPTA
AVTLLRLQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPEAVRVPVLSG
GHGPAERITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAVLFDDPVDLLDAQGNPIR
VTSRGMFSADPARLRVRGRDDRLRWWAGPWPDDERWWDPDRASGRTARAQVLLDGDPG
TALLLCYRQRRWYLEGSYE"
gene complement(3811022..3811636)
/locus_tag="Rv3395c"
CDS complement(3811022..3811636)
/codon_start=1
/transl_table=11
/locus_tag="Rv3395c"
/product="Conserved hypothetical protein"
/note="Rv3395c, (MTCY78.33), len: 204 aa. Conserved
hypothetical protein, with some similarity with RECA
proteins (recombinases A) e.g. P16238|RECA_THIFE from
Thiobacillus ferrooxidans (346 aa), FASTA scores: opt:
131,E(): 1.1, (31.45% identity in 140 aa overlap);
Q59560|RECA_MYCSM from Mycobacterium smegmatis (349
aa),FASTA scores: opt: 121, E(): 4.4, (30.25% identity in
129 aa overlap); etc. Note that shortened since first
submission to avoid overlap with Rv3395A. Equivalent to
AAK47839 from Mycobacterium tuberculosis strain CDC1551
(227 aa) but shorter 23 aa."
/db_xref="EnsemblGenomes-Gn:Rv3395c"
/db_xref="EnsemblGenomes-Tr:CCP46216"
/db_xref="GOA:P9WKZ9"
/db_xref="UniProtKB/Swiss-Prot:P9WKZ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46216.1"
/translation="MTAAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVP
AGPVSLPPGTVGVLSGARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRL
AVIPDPGTDPVEVAAVLIDGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGD
WQGVSTRLAARVCGYEITPALRGVPTPGLGRISGVRLQINGRGR"
gene 3811719..3812345
/locus_tag="Rv3395A"
CDS 3811719..3812345
/codon_start=1
/transl_table=11
/locus_tag="Rv3395A"
/product="Probable membrane protein"
/note="Rv3395A, len: 208 aa. Probable membrane
protein,with potential transmembrane stretches from aa
7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C
putative lipoprotein from Streptomyces coelicolor (258
aa), FASTA scores: opt: 107, E(): 7.4, (34.05% identity in
94 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3395A"
/db_xref="EnsemblGenomes-Tr:CCP46217"
/db_xref="UniProtKB/TrEMBL:Q6MWX4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46217.1"
/translation="MQSRKTTSVLAAALLFCGLLGPGTAPPATGGGPACRPAELFATD
NTTDGFELPAVATIALTGTVVTGSTLVDGVFWSNERQQIGYERSREFHLCVVDAPTLH
NAAEALHRQFNQEAVLTFDYLPQNAPEADAILITVPDIGIARFRDAFASDLAAHHRLR
GGSVTTADHTLILVAGNGDLDVARRLVEEAGGDWNATTIAHGRREFVN"
gene complement(3812501..3814078)
/gene="guaA"
/locus_tag="Rv3396c"
CDS complement(3812501..3814078)
/codon_start=1
/transl_table=11
/gene="guaA"
/locus_tag="Rv3396c"
/product="Probable GMP synthase [glutamine-hydrolyzing]
GuaA (glutamine amidotransferase) (GMP synthetase)"
/note="Rv3396c, (MTCY78.32), len: 525 aa. Probable
guaA,gmp synthase (see citation below), equivalent to
P46810|GUAA_MYCLE|ML0395|B1620_C2_205 GMP synthase
[glutamine-hydrolyzing] from Mycobacterium leprae (529
aa),FASTA scores: opt: 2992, E(): 8.5e-168, (86.85%
identity in 525 aa overlap). Also highly similar to others
e.g. O52831|GUAA_CORAM from Corynebacterium ammoniagenes
(Brevibacterium ammoniagenes) (524 aa), FASTA scores: opt:
2636, E(): 5.9e-147, (76.2% identity in 521 aa overlap);
Q9L0H2|GUAA_STRCO from Streptomyces coelicolor (526
aa),FASTA scores: opt: 2451, E(): 4.1e-136, (71.55%
identity in 513 aa overlap); Q9KF78|GUAA_BACHD from
Bacillus Halodurans (513 aa), FASTA scores: opt: 1819,
E(): 4.1e-99, (52.55% identity in 510 aa overlap); etc.
Contains PS00442 Glutamine amidotransferases class-I
active site. Belongs to the type-1 glutamine
amidotransferase family in the N-terminal section. And
belongs to the GMP synthase family in the C-terminal
section."
/db_xref="EnsemblGenomes-Gn:Rv3396c"
/db_xref="EnsemblGenomes-Tr:CCP46218"
/db_xref="GOA:P9WMS7"
/db_xref="InterPro:IPR001674"
/db_xref="InterPro:IPR004739"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR017926"
/db_xref="InterPro:IPR022310"
/db_xref="InterPro:IPR022955"
/db_xref="InterPro:IPR025777"
/db_xref="InterPro:IPR029062"
/db_xref="UniProtKB/Swiss-Prot:P9WMS7"
/inference="protein motif:PROSITE:PS00442"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46218.1"
/translation="MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVI
PHTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQA
LGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAG
APVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQ
VRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFV
AATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLV
QGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGL
PEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVL
LADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVN
RVVLDITSKPPATIEWE"
gene complement(3814090..3814998)
/gene="phyA"
/gene_synonym="crtB"
/locus_tag="Rv3397c"
CDS complement(3814090..3814998)
/codon_start=1
/transl_table=11
/gene="phyA"
/gene_synonym="crtB"
/locus_tag="Rv3397c"
/product="Probable phytoene synthase PhyA"
/note="Rv3397c, (MTCY78.31), len: 302 aa. Probable phyA
(alternate gene name: crtB), phytoene synthase, similar to
many others e.g. Q9X7V5|SC6A5.09 from Streptomyces
coelicolor (312 aa), FASTA scores: opt: 791, E():
2.8e-43,(48.25% identity in 286 aa overlap); Q9RW07|DR0862
from Deinococcus radiodurans (325 aa), FASTA scores: opt:
482,E(): 1.5e-23, (35.25% identity in 292 aa overlap);
Q9JRU9|NMB1168|NMB1130 from Neisseria meningitidis
(serogroup B) (290 aa), FASTA scores: opt: 446, E():
2.8e-21, (34.25% identity in 260 aa overlap);
P37272|PSY_CAPAN from Capsicum annuum (Bell pepper) (419
aa), FASTA scores: opt: 431, E(): 3.4e-20, (33.0% identity
in 288 aa overlap); etc. Also similar to Q9JUF5|NMA1339
putative poly-isoprenyl transferase from Neisseria
meningitidis (serogroup A) (290 aa), FASTA scores: opt:
450, E(): 1.6e-21, (34.6% identity in 260 aa overlap). And
similar to crtB|O05424 phytoene synthase from
Mycobacterium marinum (319 aa), blastp scores: 113, E=
6e-24, Identities = 89/283 (31%) (see citation below).
Contains PS01045 Squalene and phytoene synthases signature
2. Belongs to the phytoene/squalene synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv3397c"
/db_xref="EnsemblGenomes-Tr:CCP46219"
/db_xref="GOA:P9WHP3"
/db_xref="InterPro:IPR008949"
/db_xref="InterPro:IPR017828"
/db_xref="InterPro:IPR019845"
/db_xref="InterPro:IPR033904"
/db_xref="UniProtKB/Swiss-Prot:P9WHP3"
/inference="protein motif:PROSITE:PS01045"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46219.1"
/translation="MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALG
RRIDDVADGELAPETKITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAEL
IDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQ
TNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAAD
WYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAA
AALASSVTCGPAHGPLPADLGSHPSH"
gene complement(3815027..3816106)
/gene="idsA1"
/gene_synonym="idsA"
/locus_tag="Rv3398c"
CDS complement(3815027..3816106)
/codon_start=1
/transl_table=11
/gene="idsA1"
/gene_synonym="idsA"
/locus_tag="Rv3398c"
/product="Probable multifunctional geranylgeranyl
pyrophosphate synthetase IdsA1 (GGPP synthetase)
(ggppsase) (geranylgeranyl diphosphate synthase):
dimethylallyltransferase (prenyltransferase)
(geranyl-diphosphate synthase) + geranyltranstransferase
(farnesyl-diphosphate synthase) (farnesyl-pyrophosphate
synthetase) (farnesyl diphosphate synthetase) (FPP
synthetase) + farnesyltranstransferase
(geranylgeranyl-diphosphate synthase)"
/note="Rv3398c, (MTCY78.30), len: 359 aa. Probable
idsA1,geranylgeranyl pyrophosphate synthetase (GGPP
synthetase) including: dimethylallyltransferase
,geranyltranstransferase, and farnesyltranstransferase.
Most similar to AE000797_3|O26156|Q53479 bifunctional
short chain isoprenyl diphosphate synthase from
Methanobacterium thermoautotrop (325 aa), FASTA scores:
opt: 605, E(): 0,(37.1% identity in 329 aa overlap);
homology suggests ATG at 30121 or TTG at 30145 to be the
initiation codon. Contains PS00444 Polyprenyl synthetases
signature 2. Belongs to the FPP/GGPP synthetases family;
belongs to a family that groups together FPP synthetase,
GGPP synthetase and hexaprenyl pyrophosphate synthetase.
Note that previously known as idsA."
/db_xref="EnsemblGenomes-Gn:Rv3398c"
/db_xref="EnsemblGenomes-Tr:CCP46220"
/db_xref="GOA:P9WKH1"
/db_xref="InterPro:IPR000092"
/db_xref="InterPro:IPR008949"
/db_xref="InterPro:IPR033749"
/db_xref="UniProtKB/Swiss-Prot:P9WKH1"
/inference="protein motif:PROSITE:PS00444"
/protein_id="CCP46220.1"
/translation="MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADR
LDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVE
LVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVG
AALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAG
APRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVA
HGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMV
ARIGIPDRPAAELQDLAHYIVDRQA"
gene 3816129..3817175
/locus_tag="Rv3399"
CDS 3816129..3817175
/codon_start=1
/transl_table=11
/locus_tag="Rv3399"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv3399, (MTCY78.29c), len: 348 aa. Possible
S-adenosylmethionine-dependent methyltransferase (see
Grana et al., 2007), similar to other Mycobacterium
tuberculosis (strains H37Rv and CDC1551) hypothetical
proteins e.g. P95074|Rv0726c|MTCY210.45c (367 aa), FASTA
scores: opt: 1188, E(): 7.7e-69, (60.05% identity in 308
aa overlap); MTCY31.21c (38.0% identity in 308 aa
overlap), MTV041_5,MTCY4C12_14, MTY13D12_21, MTV043_22,
MTCY210_44, MTCI5_19,MTCI5_20, MTV035_9, MTCY180_22,
MTCY31_23, MTY13D12_1,MTCY180_29; etc."
/db_xref="EnsemblGenomes-Gn:Rv3399"
/db_xref="EnsemblGenomes-Tr:CCP46221"
/db_xref="GOA:P9WFH1"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFH1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46221.1"
/translation="MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMT
RTDNDTWDLASSVGATATMIATARALASRAENPLINDPFAEPLVRAVGIDLFTRLASG
ELRLEDIGDHATGGRWMIDNIAIRTKFYDDFFGDATTAGIRQVVILAAGLDTRAYRLP
WPPGTVVYEIDQPAVIKFKTRALANLNAEPNAERHAVAVDLRNDWPTALKNAGFDPAR
PTAFSAEGLLSYLPPQGQDRLLDAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSA
AEAWRERGFDLDLTELIYFDQRNDVADYLAGSGWQVTTSTGKELFAAQGLPPFADDHI
TRFADRRYISAVLK"
gene 3817239..3818027
/locus_tag="Rv3400"
CDS 3817239..3818027
/codon_start=1
/transl_table=11
/locus_tag="Rv3400"
/product="Probable hydrolase"
/note="Rv3400, (MTCY78.28c), len: 262 aa. Probable
hydrolase, strongly equivalent to
Q49741|YY00_MYCLE|ML0393|B1620_F3_119 hypothetical 28.6
KDA protein from Mycobacterium leprae (261 aa), FASTA
scores: opt: 1293, E(): 2.2e-71, (74.45% identity in 262
aa overlap). Similar to several various proteins (notably
hydrolases) e.g. Q9L2I7|SCF42.32 putative hydrolase from
Streptomyces coelicolor (246 aa), FASTA scores: opt:
888,E(): 7.7e-47, (56.35% identity in 245 aa overlap);
Q9EX06|2SCG38.13 putative hydrolase from Streptomyces
coelicolor (238 aa), FASTA scores: opt: 195, E():
8.1e-05,(29.5% identity in 234 aa overlap); Q9I5X4|PA0562
probable hydrolase from Pseudomonas aeruginosa (224 aa),
FASTA scores: opt: 190, E(): 0.00015, (27.8% identity in
248 aa overlap); O06995|PGMB_BACSU|YVDM putative
beta-phosphoglucomutase from Bacillus subtilis (226
aa),FASTA scores: opt: 190, E(): 0.00016, (33.9% identity
in 245 aa overlap); etc. Also similar to Mycobacterium
tuberculosis hypothetical protein
Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),
FASTA scores: opt: 413, E(): 2e-17, (34.9% identity in 238
aa overlap). Interestingly, note that Rv3400 and Rv3401
are similar to beginning and end of
Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx.
270 aa missing from the middle."
/db_xref="EnsemblGenomes-Gn:Rv3400"
/db_xref="EnsemblGenomes-Tr:CCP46222"
/db_xref="GOA:P9WKZ7"
/db_xref="InterPro:IPR006439"
/db_xref="InterPro:IPR010976"
/db_xref="InterPro:IPR023198"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="InterPro:IPR041492"
/db_xref="UniProtKB/Swiss-Prot:P9WKZ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46222.1"
/translation="MANWYRPNYPEVRSRVLGLPEKVRACLFDLDGVLTDTASLHTKA
WKAMFDAYLAERAERTGEKFVPFDPAADYHTYVDGKKREDGVRSFLSSRAIEIPDGSP
DDPGAAETVYGLGNRKNDMLHKLLRDDGAQVFDGSRRYLEAVTAAGLGVAVVSSSANT
RDVLATTGLDRFVQQRVDGVTLREEHIAGKPAPDSFLRAAELLGVTPDAAAVFEDALS
GVAAGRAGNFAVVVGINRTGRAAQAAQLRRHGADVVVTDLAELL"
gene 3818042..3820402
/locus_tag="Rv3401"
CDS 3818042..3820402
/codon_start=1
/transl_table=11
/locus_tag="Rv3401"
/product="Conserved protein"
/note="Rv3401, (MTCY78.27c), len: 786 aa. Conserved
protein, may be an hydrolase or a transferase, equivalent
to Q49736|ML0392|B1620_F1_30 hypothetical 88.1 KDA protein
from Mycobacterium leprae (792 aa), FASTA scores: opt:
4820, E(): 0, (91.45% identity in 782 aa overlap). Also
highly similar to Q9L2I8|SCF42.31c putative glycosyl
transferase from Streptomyces coelicolor (792 aa), FASTA
scores: opt: 3060, E(): 2.9e-179, (59.25% identity in 785
aa overlap); and similar to others e.g. Q9K109|NMB0390
maltose phosphorylase from Neisseria meningitidis
(serogroup B) (752 aa), FASTA scores: opt: 980, E():
3.5e-52, (29.2% identity in 774 aa overlap);
Q9JSW8|MAPA|NMA2098 putative maltose phosphorylase from
Neisseria meningitidis (serogroup A) (752 aa), FASTA
scores: opt: 956, E(): 1e-50, (28.4% identity in 764 aa
overlap); O06993|YVDK_BACSU hypothetical 88.3 KDA protein
(belongs to family 65 of glycosyl hydrolases) from
Bacillus subtilis (757 aa), FASTA scores: opt: 926, E():
6.9e-49,(28.5% identity in 754 aa overlap); Q9CF04|MAPA
maltosephosphorylase from Lactococcus lactis (subsp.
lactis) (Streptococcus lactis) (751 aa), FASTA scores:
opt: 907, E(): 1e-47, (26.95% identity in 753 aa overlap);
P77154|YCJT_ECOLI|B1316 hypothetical 84.9 KDA protein
(belongs to family 65 of glycosyl hydrolases) from
Escherichia coli strain K12 (755 aa), FASTA scores: opt:
392, E(): 2.9e-16, (27.5% identity in 774 aa overlap);
etc. Also similar to Mycobacterium tuberculosis
hypothetical protein
Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c (1327 aa),
(27.2% identity in 802 aa overlap); note that Rv3400 and
Rv3401 are similar to beginning and end of
Q10850|YK06_MYCTU|Rv2006|MT2062|MTCY39.11c with approx.
270 aa missing from the middle."
/db_xref="EnsemblGenomes-Gn:Rv3401"
/db_xref="EnsemblGenomes-Tr:CCP46223"
/db_xref="GOA:P9WN13"
/db_xref="InterPro:IPR005194"
/db_xref="InterPro:IPR005195"
/db_xref="InterPro:IPR005196"
/db_xref="InterPro:IPR008928"
/db_xref="InterPro:IPR011013"
/db_xref="InterPro:IPR012341"
/db_xref="InterPro:IPR017045"
/db_xref="InterPro:IPR037018"
/db_xref="UniProtKB/Swiss-Prot:P9WN13"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46223.1"
/translation="MITEDAFPVEPWQVRETKLNLNLLAQSESLFALSNGHIGLRGNL
DEGEPFGLPGTYLNSFYEIRPLPYAEAGYGYPEAGQTVVDVTNGKIFRLLVGDEPFDV
RYGELISHERILDLRAGTLTRRAHWRSPAGKQVKVTSTRLVSLAHRSVAAIEYVVEAI
EEFVRVTVQSELVTNEDVPETSADPRVSAILDRPLQAVEHERTERGALLMHRTRASAL
MMAAGMEHEVEVPGRVEITTDARPDLARTTVICGLRPGQKLRIVKYLAYGWSSLRSRP
ALRDQAAGALHGARYSGWQGLLDAQRAYLDDFWDSADVEVEGDPECQQAVRFGLFHLL
QASARAERRAIPSKGLTGTGYDGHAFWDTEGFVLPVLTYTAPHAVADALRWRASTLDL
AKERAAELGLEGAAFPWRTIRGQESSAYWPAGTAAWHINADIAMAFERYRIVTGDGSL
EEECGLAVLIETARLWLSLGHHDRHGVWHLDGVTGPDEYTAVVRDNVFTNLMAAHNLH
TAADACLRHPEAAEAMGVTTEEMAAWRDAADAANIPYDEELGVHQQCEGFTTLAEWDF
EANTTYPLLLHEAYVRLYPAQVIKQADLVLAMQWQSHAFTPEQKARNVDYYERRMVRD
SSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHRNTRDGLHMASLAGAWTALVV
GFGGLRDDEGILSIDPQLPDGISRLRFRLRWRGFRLIVDANHTDVTFILGDGPGTQLT
MRHAGQDLTLHTDTPSTIAVRTRKPLLPPPPQPPGREPVHRRALAR"
gene complement(3820653..3821891)
/locus_tag="Rv3402c"
CDS complement(3820653..3821891)
/codon_start=1
/transl_table=11
/locus_tag="Rv3402c"
/product="Conserved hypothetical protein"
/note="Rv3402c, (MTCY78.26), len: 412 aa. Conserved
hypothetical protein, probably involved in cell
process,similar to various proteins generally involved in
extracellular compounds (lipopolysaccharide O-antigen)
biosynthesis e.g. O68392|RFBE perosamine synthetase from
Brucella melitensis (367 aa), FASTA scores: opt: 420, E():
1.2e-19, (26.15% identity in 375 aa overlap); Q9L6C1
3,4-dehydratase-like protein from Streptomyces
antibioticus (393 aa), FASTA scores: opt: 419, E():
1.5e-19, (30.65% identity in 385 aa overlap); Q9RR26|OLENI
dehydratase from Streptomyces antibioticus (393 aa), FASTA
scores: opt: 416,E(): 2.3e-19, (30.65% identity in 385 aa
overlap); O33942 eryciv protein from Saccharopolyspora
erythraea (Streptomyces erythraeus) (401 aa), FASTA
scores: opt: 410,E(): 5.6e-19, (31.75% identity in 362 aa
overlap); Q9UZI4|ASPB-LIKE1|PAB0774 aspartate
aminotransferase (ASPB-LIKE1) from Pyrococcus abyssi (366
aa), FASTA scores: opt: 402, E(): 1.7e-18, (27.05%
identity in 377 aa overlap); O88001|WLBC putative
amino-sugar biosynthesis protein from Bordetella
bronchiseptica (Alcaligenes bronchisepticus) (366 aa),
FASTA scores: opt: 394, E(): 5.6e-18, (26.8% identity in
347 aa overlap); Q45378|BPLC DNA for lipopolysaccharide
biosynthesis from Bordetella pertussis (366 aa), FASTA
scores: opt: 393, E(): 6.5e-18,(26.8% identity in 347 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3402c"
/db_xref="EnsemblGenomes-Tr:CCP46224"
/db_xref="GOA:P9WGJ7"
/db_xref="InterPro:IPR000653"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/Swiss-Prot:P9WGJ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46224.1"
/translation="MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPS
FPGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAAL
HVSFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERF
RDRIAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGAC
EIFSFHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISA
AIGLRQLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKA
AVLGSLRRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHM
APDDVARVVAAVQEAEVRGE"
gene complement(3822262..3823863)
/locus_tag="Rv3403c"
CDS complement(3822262..3823863)
/codon_start=1
/transl_table=11
/locus_tag="Rv3403c"
/product="Hypothetical protein"
/note="Rv3403c, (MTCY78.25), len: 533 aa. Hypothetical
unknown protein, but some weak similarity to Q9KJP2
hypothetical 54.9 KDA protein from Myxococcus xanthus (504
aa), FASTA scores: opt: 157, E(): 0.011, (24.1% identity
in 548 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3403c"
/db_xref="EnsemblGenomes-Tr:CCP46225"
/db_xref="GOA:P9WKZ5"
/db_xref="InterPro:IPR036188"
/db_xref="InterPro:IPR038732"
/db_xref="UniProtKB/Swiss-Prot:P9WKZ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46225.1"
/translation="MLAFPYLMTMITPPTFDVAFIGSGAACSMTLLEMADALLSSPSA
SPKLRIAVVERDEQFWCGIPYGQRSSIGSLAIQKLDDFADEPEKAAYRIWLEQNKQRW
LAFFQAEGGAAAARWICDNRDALDGNQWGELYLPRFLFGVFLSEQMIAAIAALGERDL
AEIVTIRAEAMSAHSADGHYRIGLRPSGNGPTAIAAGKVVVAIGSPPTKAILASDSEP
AFTYINDFYSPGGESNVARLRDSLDRVESWEKRNVLVVGSNATSLEALYLMRHDARIR
ARVRSITVISRSGVLPYMICNQPPEFDFPRLRTLLCTEAIAAADLMSAIRDDLATAEE
RSLNLADLYDAVAALFGQALHKMDLVQQEEFFCVHGMNFTKLVRRAGRDCRQASEELA
ADGTLSLLAGEVLRVDACASGQPFATMTYRAAGAEHTHPVPFAAVVNCGGFEELDTCS
SPFLVSAMQNGLCRPNRTNRGLLVNDDFEASPGFCVIGPLVGGNFTPKIRFWHVESAP
RVRSLAKSLAASLLASLQPVALAPC"
gene complement(3823880..3824584)
/locus_tag="Rv3404c"
CDS complement(3823880..3824584)
/codon_start=1
/transl_table=11
/locus_tag="Rv3404c"
/product="Conserved hypothetical protein"
/note="Rv3404c, (MTCY78.24), len: 234 aa. Conserved
hypothetical protein, some similarity to several
methionyl-tRNA formyltransferases e.g. BAB51418|MLL4854
from Rhizobium loti (Mesorhizobium loti) (317 aa), FASTA
scores: opt: 210, E(): 1.7e-06, (27.55% identity in 178 aa
overlap); P94463|FMT_BACSU from Bacillus subtilis (317
aa),FASTA scores: opt: 199 ,E(): 8.8e-06, (28.25% identity
in 177 aa overlap); O51091||FMT_BORBU|BB0064 from Borrelia
burgdorferi (Lyme disease spirochete) (312 aa), FASTA
scores: opt: 187, E(): 5.2e-05, (30.2% identity in 192 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3404c"
/db_xref="EnsemblGenomes-Tr:CCP46226"
/db_xref="GOA:P9WKZ3"
/db_xref="InterPro:IPR002376"
/db_xref="InterPro:IPR036477"
/db_xref="InterPro:IPR040660"
/db_xref="PDB:4PZU"
/db_xref="PDB:4Q12"
/db_xref="PDB:5VYQ"
/db_xref="UniProtKB/Swiss-Prot:P9WKZ3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46226.1"
/translation="MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDV
AERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQ
KVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGS
YTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGR
KVFVRVVLEPEKPAEA"
gene complement(3824702..3825268)
/locus_tag="Rv3405c"
CDS complement(3824702..3825268)
/codon_start=1
/transl_table=11
/locus_tag="Rv3405c"
/product="Possible transcriptional regulatory protein"
/note="Rv3405c, (MTCY78.23), len: 188 aa. Possible
transcriptional regulator, showing weak similarity to
other bacterial regulatory proteins e.g. Q9KE70|BH0987
from Bacillus halodurans (203 aa), FASTA scores: opt: 168,
E(): 0.0016, (34.8% identity in 92 aa overlap);
Q9A5F7|CC2493 Caulobacter crescentus (204 aa), FASTA
scores: opt: 160,E(): 0.0051, (32.6% identity in 89 aa
overlap); Q9RDR0|SC4A7.02 from Streptomyces coelicolor
(227 aa),FASTA scores: opt: 159, E(): 0.0064, (37.0%
identity in 189 aa overlap); etc. Also some similarity to
hypothetical Mycobacterium tuberculosis regulatory
proteins e.g. O05858|Rv3208|MTCY07D11.18c, MTCI125_6,
MTCY7D11_18,MTCY10G2_30; etc. Contains potential
helix-turn-helix motif from aa 39-60 (+2.97 SD)."
/db_xref="EnsemblGenomes-Gn:Rv3405c"
/db_xref="EnsemblGenomes-Tr:CCP46227"
/db_xref="GOA:P9WMC3"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="UniProtKB/Swiss-Prot:P9WMC3"
/protein_id="CCP46227.1"
/translation="MTTRPATDRRKMPTGREEVAAAILQAATDLFAERGPAATSIRDI
AARSKVNHGLVFRHFGTKDQLVGAVLDHLGTKLTRLLHSEAPADIIERALDRHGRVLA
RALLDGYPVGQLQQRFPNVAELLDAVRPRYDSDLGARLAVAHALALQFGWRLFAPMLR
SATGIDELTGDELRLSVNDAVARILEPH"
gene 3825330..3826217
/locus_tag="Rv3406"
CDS 3825330..3826217
/codon_start=1
/transl_table=11
/locus_tag="Rv3406"
/product="Probable dioxygenase"
/note="Rv3406, (MTCY78.22c), len: 295 aa. Probable
dioxygenase, highly similar to Q9WWU|ATSK putative
alpha-ketoglutarate dependent dioxygenase from Pseudomonas
putida (301 aa), FASTA scores: opt: 994, E():
3.9e-57,(53.7% identity in 283 aa overlap); Q9I6U1|PA0193
hypothetical protein from Pseudomonas aeruginosa (300
aa),FASTA scores: opt: 1024, E(): 4.4e-59, (53.65%
identity in 287 aa overlap); Q9HX81|TAUD|PA3935 taurine
dioxygenase from Pseudomonas aeruginosa (277 aa), FASTA
scores: opt: 599, E(): 1.4e-31, (39.35% identity in 277 aa
overlap); and similar to other dioxygenases e.g.
AAG54718|TAUD (alias BAB33845|ECS0422) taurine dioxygenase
2-oxoglutarate-dependent from Escherichia coli strain
O157:H7 (283 aa), FASTA scores: opt: 595, E():
2.5e-31,(38.1% identity in 281 aa overlap); etc. Belongs
to the TfdA family of dioxygenases."
/db_xref="EnsemblGenomes-Gn:Rv3406"
/db_xref="EnsemblGenomes-Tr:CCP46228"
/db_xref="GOA:P9WKZ1"
/db_xref="InterPro:IPR003819"
/db_xref="InterPro:IPR042098"
/db_xref="PDB:4CVY"
/db_xref="PDB:4FFA"
/db_xref="UniProtKB/Swiss-Prot:P9WKZ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46228.1"
/translation="MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKV
VFFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVT
FAANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVT
TKPLTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVL
FEVLQRRITMPENTIRWNWAPGDVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPV
DVYGQASRVISGAPMEIAG"
gene 3826252..3826551
/gene="vapB47"
/locus_tag="Rv3407"
CDS 3826252..3826551
/codon_start=1
/transl_table=11
/gene="vapB47"
/locus_tag="Rv3407"
/product="Possible antitoxin VapB47"
/note="Rv3407, (MTCY78.21c), len: 99 aa. Possible
vapB47,antitoxin, part of toxin-antitoxin (TA) operon with
Rv3408,see Arcus et al. 2005. Similar to others in
Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g.
AAK46285|MT2013 (90 aa), FASTA scores: opt: 160, E():
0.00021, (37.1% identity in 89 aa overlap);
O50412|Rv3385c|MTV004.43c (102 aa), FASTA scores: opt:
155, E(): 0.00051, (41.05% identity in 78 aa overlap),
MTCY19H5.26, MTCY20H10.07, MTI376.09c,MTCY427.21, etc."
/db_xref="EnsemblGenomes-Gn:Rv3407"
/db_xref="EnsemblGenomes-Tr:CCP46229"
/db_xref="GOA:P9WF23"
/db_xref="InterPro:IPR006442"
/db_xref="InterPro:IPR036165"
/db_xref="UniProtKB/Swiss-Prot:P9WF23"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46229.1"
/translation="MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVAR
LIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRTLSDVLNEMRDEQ"
gene 3826548..3826958
/gene="vapC47"
/locus_tag="Rv3408"
CDS 3826548..3826958
/codon_start=1
/transl_table=11
/gene="vapC47"
/locus_tag="Rv3408"
/product="Possible toxin VapC47. Contains PIN domain."
/note="Rv3408, (MTCY78.20c), len: 136 aa. Possible
vapC47,toxin, part of toxin-antitoxin (TA) operon with
Rv3407,contains PIN domain, see Arcus et al. 2005. Similar
to others in Mycobacterium tuberculosis strains H37Rv and
CDC1551 e.g. O50411|Rv3384c|MTV004.42c (130 aa), FASTA
scores: opt: 243, E(): 1.7e-09, (35.1% identity in 131 aa
overlap); P95252|Rv1962c|MTCY09F9.02 (135 aa), FASTA
scores: opt: 191, E(): 5e-06, (35.5% identity in 138 aa
overlap), etc."
/db_xref="EnsemblGenomes-Gn:Rv3408"
/db_xref="EnsemblGenomes-Tr:CCP46230"
/db_xref="GOA:P9WF49"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46230.1"
/translation="MIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRV
ESMRVVARYGQPGQTERARYLLDGLDILPLTEPVIGLAETIGPATLRSLDAIHLAAAA
QIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR"
gene complement(3826991..3828727)
/gene="choD"
/locus_tag="Rv3409c"
CDS complement(3826991..3828727)
/codon_start=1
/transl_table=11
/gene="choD"
/locus_tag="Rv3409c"
/product="Cholesterol oxidase ChoD (cholesterol-O2
oxidoreductase)"
/note="Rv3409c, (MTCY78.19), len: 578 aa. ChoD,
cholesterol oxidase, equivalent to Q9CCV1|CHOD|ML0389
(alias Q59530|CHOD|B1620_C3_240) putative cholesterol
oxidase from Mycobacterium leprae (569 aa), FASTA scores:
opt: 3510,E(): 3.8e-198, (88.6% identity in 569 aa
overlap). Belongs to the GMC oxidoreductases family.
Cofactor: FAD flavoprotein. Contains PS00017
ATP/GTP-binding site motif A."
/db_xref="EnsemblGenomes-Gn:Rv3409c"
/db_xref="EnsemblGenomes-Tr:CCP46231"
/db_xref="GOA:P9WMV9"
/db_xref="InterPro:IPR007867"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WMV9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46231.1"
/translation="MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEF
AKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFA
DQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPV
GVFFGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAE
SAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHL
LFKMRDRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADT
HIEPVRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQW
SERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAK
IDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISA
NLGVNPSLSIAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGAL
RWLPIDPVSNAG"
gene complement(3828783..3829910)
/gene="guaB3"
/locus_tag="Rv3410c"
CDS complement(3828783..3829910)
/codon_start=1
/transl_table=11
/gene="guaB3"
/locus_tag="Rv3410c"
/product="Probable inosine-5'-monophosphate dehydrogenase
GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase)
(inosinate dehydrogenase) (imp oxidoreductase)
(inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD)"
/note="Rv3410c, (MTCY78.18), len: 375 aa. Probable
guaB3,inosine-5'-monophosphate (imp) dehydrogenase,
equivalent to Q49721|YY10_MYCLE|ML0388|B1620_C2_193
hypothetical 38.9 KDA protein from Mycobacterium leprae
(375 aa), FASTA scores: opt: 2182, E(): 9.5e-122, (90.6%
identity in 373 aa overlap). Highly similar to Q9RHY9 GUAB
ORF genes for imp dehydrogenase, hypothetical protein from
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
(376 aa), FASTA scores: opt: 1490, E(): 7.6e-81, (61.0%
identity in 382 aa overlap); Q9L0I6|SCD63.03 putative
inosine-5'-monophosphate dehydrogenase from Streptomyces
coelicolor (374 aa), FASTA scores: opt: 1275, E():
3.8e-68, (52.95% identity in 372 aa overlap);
P73853|GUAB|SLR1722 imp dehydrogenase subunit from
Synechocystis sp. strain PCC 6803 (387 aa), FASTA scores:
opt: 882, E(): 6.7e-45, (41.3% identity in 373 aa
overlap); and similar to other inosine-5'-monophosphate
dehydrogenases e.g. P44334|IMDH_HAEIN|GUAB|HI0221 from
Haemophilus influenzae (488 aa), FASTA scores: opt:
267,E(): 1.8e-08, (34.25% identity in 216 aa overlap);
etc. Also highly similar to the C-terminus of
Q50753|GUAA/B homology to Mycobacterium leprae GUAA
(fragment) from Mycobacterium tuberculosis (130 aa), FASTA
scores: opt: 506, E(): 4.6e-23, (85.05% identity in 87 aa
overlap). Similar to other eukaryotic and prokaryotic
IMPDH and to GMP reductase."
/db_xref="EnsemblGenomes-Gn:Rv3410c"
/db_xref="EnsemblGenomes-Tr:CCP46232"
/db_xref="GOA:P9WKI5"
/db_xref="InterPro:IPR001093"
/db_xref="InterPro:IPR005992"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/Swiss-Prot:P9WKI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46232.1"
/translation="MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRF
EIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPE
PSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDL
LVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVG
YGSTQGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDIHTSGELA
KAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALLQIAVGERPPLARVL
GGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG"
gene complement(3829930..3831519)
/gene="guaB2"
/locus_tag="Rv3411c"
CDS complement(3829930..3831519)
/codon_start=1
/transl_table=11
/gene="guaB2"
/locus_tag="Rv3411c"
/product="Probable inosine-5'-monophosphate dehydrogenase
GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase)
(inosinate dehydrogenase) (imp oxidoreductase)
(inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD)"
/note="Rv3411c, (MTCY78.17), len: 529 aa. Probable
guaB2,inosine-5'-monophosphate (imp) dehydrogenase,
equivalent to Q49729|IMDH_MYCLE|GUAB|ML0387|B1620_C3_238
inosine-5'-monophosphate dehydrogenase from Mycobacterium
leprae (529 aa), FASTA scores: opt: 3154, E():
4.4e-165,(92.45% identity in 529 aa overlap). Highly
similar to other inosine-5'-monophosphate dehydrogenases
e.g. Q9RHZ0|GUAB from Corynebacterium ammoniagenes
(Brevibacterium ammoniagenes) (506 aa), FASTA scores: opt:
2284, E(): 1.5e-117, (67.9% identity in 505 aa overlap);
Q9L0I7|SCD63.02 from Streptomyces coelicolor (501
aa),FASTA scores: opt: 2178, E(): 9e-112, (67.2% identity
in 491 aa overlap); O67820|IMDH_AQUAE|GUAB|AQ_2023 from
Aquifex aeolicus (490 aa), FASTA scores: opt: 1820, E():
3.2e-92, (58.1% identity in 487 aa overlap); etc. Also
similar to Q50716|YY10_MYCTU|Rv3410c|MT3518|MTCY78.18
hypothetical 38.9 KDA protein from Mycobacterium
tuberculosis (38.6% identity in 158 aa overlap). Contains
PS00487 imp dehydrogenase / GMP reductase signature.
Similar to other eukaryotic and prokaryotic IMPDH and to
GMP reductase."
/db_xref="EnsemblGenomes-Gn:Rv3411c"
/db_xref="EnsemblGenomes-Tr:CCP46233"
/db_xref="GOA:P9WKI7"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR001093"
/db_xref="InterPro:IPR005990"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR015875"
/db_xref="PDB:4ZQM"
/db_xref="PDB:4ZQN"
/db_xref="PDB:4ZQO"
/db_xref="PDB:4ZQP"
/db_xref="PDB:4ZQR"
/db_xref="PDB:5UPU"
/db_xref="PDB:5UPV"
/db_xref="UniProtKB/Swiss-Prot:P9WKI7"
/inference="protein motif:PROSITE:PS00487"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46233.1"
/translation="MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLG
LTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGG
MGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVV
DDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKL
PVVDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAG
VDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVG
VGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGAS
TAMLGSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDAL
SEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAG
LKESHPHDVAMTVEAPNYYAR"
gene 3831726..3832136
/locus_tag="Rv3412"
CDS 3831726..3832136
/codon_start=1
/transl_table=11
/locus_tag="Rv3412"
/product="Conserved hypothetical protein"
/note="Rv3412, (MTCY78.16c), len: 136 aa. Hypothetical
protein, strongly similar to
Q49742|YY12_MYCLE|ML0386|B1620_F3_131 hypothetical 15.3
KDA protein from Mycobacterium leprae (137 aa), FASTA
scores: opt: 933, E(): 6.3e-52, (93.4% identity in 136 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3412"
/db_xref="EnsemblGenomes-Tr:CCP46234"
/db_xref="InterPro:IPR035165"
/db_xref="UniProtKB/Swiss-Prot:P9WKY9"
/protein_id="CCP46234.1"
/translation="MRDHLPPGLPPDPFADDPCDPSAALEAVEPGQPLDQQERMAVEA
DLADLAVYEALLAHKGIRGLVVCCDECQQDHYHDWDMLRSNLLQLLIDGTVRPHEPAY
DPEPDSYVTWDYCRGYADASLNEAAPDADRFRRR"
gene complement(3832146..3833045)
/locus_tag="Rv3413c"
CDS complement(3832146..3833045)
/codon_start=1
/transl_table=11
/locus_tag="Rv3413c"
/product="Unknown alanine and proline rich protein"
/note="Rv3413c, (MTCY78.16), len: 299 aa. Unknown
ala-,pro-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv3413c"
/db_xref="EnsemblGenomes-Tr:CCP46235"
/db_xref="GOA:P9WJ71"
/db_xref="InterPro:IPR031928"
/db_xref="PDB:3VEP"
/db_xref="UniProtKB/Swiss-Prot:P9WJ71"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46235.1"
/translation="MREFGNPLGDRPPLDELARTDLLLDALAEREEVDFADPRDDALA
ALLGQWRDDLRWPPASALVSQDEAVAALRAGVAQRRRARRSLAAVGSVAAALLVLSGF
GAVVADARPGDLLYGLHAMMFNRSRVSDDQIVLSAKANLAKVEQMIAQGQWAEAQDEL
AEVSSTVQAVTDGSRRQDLINEVNLLNTKVETRDPNATLRPGSPSNPAAPGSVGNSWT
PLAPVVEPPTPPTPASAAEPSMSAGVSESPMPNSTSTVAASPSTPSSKPEPGSIDPSL
EPADEATNPAGQPAPETPVSPTH"
gene complement(3833038..3833676)
/gene="sigD"
/locus_tag="Rv3414c"
CDS complement(3833038..3833676)
/codon_start=1
/transl_table=11
/gene="sigD"
/locus_tag="Rv3414c"
/product="Probable alternative RNA polymerase sigma-D
factor SigD"
/note="Rv3414c, (MTCY78.15), len: 212 aa. Probable
sigD,alternative RNA polymerase sigma-D factor (see
citations below), similar to others (notably from
Streptomyces coelicolor) e.g. Q9L0I8|SCD63.01 from
Streptomyces coelicolor (195 aa), FASTA scores: opt: 533,
E(): 9.6e-28,(47.25% identity in 182 aa overlap);
Q9FDS3|ADSA from Streptomyces griseus (258 aa), FASTA
scores: opt: 223, E(): 1.8e-07, (28.95% identity in 183 aa
overlap); BAB48649|MLL1224 from Rhizobium loti
(Mesorhizobium loti) (187 aa), FASTA scores: opt: 202,
E(): 3.2e-06, (30.4% identity in 194 aa overlap);
P38133|RPOE_STRCO|SIGE|SCE94.07 from Streptomyces
coelicolor (176 aa), FASTA scores: opt: 200, E():
4.1e-06,(35.25% identity in 156 aa overlap);
P37978|CNRH_ALCEU from Alcaligenes eutrophus (Ralstonia
eutropha), FASTA scores: opt: 197, E(): 6.9e-06, (30.35%
identity in 191 aa overlap); etc. C-terminus strongly
similar to N-terminal part of Q49727|S1620B|B1620_C3_233
hypothetical 6.2 KDA protein from Mycobacterium leprae (59
aa), FASTA scores: opt: 217, E(): 1.3e-07, (90.25%
identity in 41 aa overlap). Belongs to the sigma-70 factor
family."
/db_xref="EnsemblGenomes-Gn:Rv3414c"
/db_xref="EnsemblGenomes-Tr:CCP46236"
/db_xref="GOA:P9WGG9"
/db_xref="InterPro:IPR000838"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039425"
/db_xref="PDB:3VEP"
/db_xref="PDB:3VFZ"
/db_xref="UniProtKB/Swiss-Prot:P9WGG9"
/protein_id="CCP46236.1"
/translation="MVDPGVSPGCVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNAL
REVLETIRPIVVRYCRARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFL
YGIAAHKVADAHRAAGRDRAYPAETLPERWSADAGPEQMAIEADSVTRMNELLEILPA
KQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAAGDYA"
gene complement(3833694..3834521)
/locus_tag="Rv3415c"
CDS complement(3833694..3834521)
/codon_start=1
/transl_table=11
/locus_tag="Rv3415c"
/product="Conserved hypothetical protein"
/note="Rv3415c, (MTCY78.14), len: 275 aa. Conserved
hypothetical protein, equivalent to Q9CCV3|ML0383
hypothetical protein from Mycobacterium leprae (281
aa),FASTA scores: opt: 1278, E(): 4.2e-71, (73.5% identity
in 279 aa overlap). Also some similarity with
P71677|RIBD_MYCTU|RIBG|Rv1409|MT1453|MTCY21B4.26
riboflavin biosynthesis protein R (339 aa), FASTA scores:
opt: 143,E(): 0.13, (28.25% identity in 184 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3415c"
/db_xref="EnsemblGenomes-Tr:CCP46237"
/db_xref="InterPro:IPR011990"
/db_xref="UniProtKB/TrEMBL:I6YG27"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46237.1"
/translation="MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAA
GGQGRYAHAYGDLSVLRRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAG
ADREAGADALIGLAADALGVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELA
MATGDGATAVRHAEEAVELTQAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEA
LDATARFGLLPLRWALACLLIDIGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA"
gene 3834892..3835200
/gene="whiB3"
/gene_synonym="whmB"
/locus_tag="Rv3416"
CDS 3834892..3835200
/codon_start=1
/transl_table=11
/gene="whiB3"
/gene_synonym="whmB"
/locus_tag="Rv3416"
/product="Transcriptional regulatory protein WhiB-like
WhiB3. Contains [4FE-4S] cluster."
/note="Rv3416, (MTCY78.13c), len: 102 aa. WhiB3 (alternate
gene name: whmB), WhiB-like regulatory protein (see
citations below), similar to WhiB paralogue of
Streptomyces coelicolor, wblE gene product (85 aa).
Equivalent to Q49871|WHIB3|WHIB|ML0382|B229_F1_2|B1620_F3_
137 probable transcription factor WHIB3 from Mycobacterium
leprae (102 aa), FASTA scores: opt: 657, E(): 7.9e-39,
(86.25% identity in 102 aa overlap). Also highly similar
to Q9Z6E9|WHIB3 from Mycobacterium smegmatis (96 aa),
FASTA scores: opt: 604, E(): 3.5e-35, (80.4% identity in
102 aa overlap); and O88103|WHID|SC6G4.45c|WBLB from
Streptomyces coelicolor (112 aa), FASTA scores: opt: 437,
E(): 1.4e-23, (62.5% identity in 96 aa overlap). Also
similar to O05847|WHIB1|Rv3219|MTCY07D11.07c from
Mycobacterium tuberculosis (84 aa), FASTA scores: opt:
215, E(): 2.5e-08,(44.45% identity in 81 aa overlap). Note
that primer extension analysis revealed three
transcriptional start sites and that expression from the
three potential promoters is growth phase-dependent (see
Mulder et al.,1999). Moreover, the transcription of this
CDS seems to be activated in macrophages (see Ramakrishnan
et al., 2000). [4Fe-4S] cluster is degraded by oxygen and
reacts with no (See Singh et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3416"
/db_xref="EnsemblGenomes-Tr:CCP46238"
/db_xref="GOA:P9WF41"
/db_xref="InterPro:IPR003482"
/db_xref="InterPro:IPR034768"
/db_xref="UniProtKB/Swiss-Prot:P9WF41"
/protein_id="CCP46238.1"
/translation="MPQPEQLPGPNADIWNWQLQGLCRGMDSSMFFHPDGERGRARTQ
REQRAKEMCRRCPVIEACRSHALEVGEPYGVWGGLSESERDLLLKGTMGRTRGIRRTA
"
gene complement(3835272..3836891)
/gene="groEL1"
/gene_synonym="cpn60_1"
/locus_tag="Rv3417c"
CDS complement(3835272..3836891)
/codon_start=1
/transl_table=11
/gene="groEL1"
/gene_synonym="cpn60_1"
/locus_tag="Rv3417c"
/product="60 kDa chaperonin 1 GroEL1 (protein CPN60-1)
(GroEL protein 1)"
/note="Rv3417c, (MTCY78.12), len: 539 aa. GroEL1
(alternate genbe name: cpn60_1), 60 kDa chaperonin 1
(protein cpn60 1) (see citations below), equivalent to
P37578|CH61_MYCLE|B1620_C3_228|GROL1|GROEL1|GROEL-
1|GROE1|ML0381|B229_ 60 KDA chaperonin 1 from
Mycobacterium leprae (537 aa),FASTA scores: opt: 2846,
E(): 1.5e-154, (82.95% identity in 539 aa overlap). Also
highly similar to others e.g.
Q00767|CH61_STRAL|GROL1|GROEL1 from Streptomyces albus G
(539 aa), FASTA scores: opt: 2130, E(): 8.1e-114, (61.9%
identity in 541 aa overlap);
P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces
coelicolor (540 aa), FASTA scores: opt: 2119, E():
3.4e-113, (61.8% identity in 542 aa overlap); etc. Also
similar to P06806|CH62_MYCTU|Q48931|Rv0440|MTV037.04|GROL2
|GROEL2|GRO EL-2|HSP65 (62.2% identity in 527 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A, PS00296
Chaperonins cpn60 signature. Belongs to the chaperonin
(HSP60) family."
/db_xref="EnsemblGenomes-Gn:Rv3417c"
/db_xref="EnsemblGenomes-Tr:CCP46239"
/db_xref="GOA:P9WPE9"
/db_xref="InterPro:IPR001844"
/db_xref="InterPro:IPR002423"
/db_xref="InterPro:IPR018370"
/db_xref="InterPro:IPR027409"
/db_xref="InterPro:IPR027410"
/db_xref="InterPro:IPR027413"
/db_xref="PDB:3M6C"
/db_xref="UniProtKB/Swiss-Prot:P9WPE9"
/inference="protein motif:PROSITE:PS00296"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46239.1"
/translation="MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFG
GPTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGG
LRLVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLV
GEAMSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALI
LLHQDKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKG
PYFGDRRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGG
GTAEAVANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKE
SVEDAVAAAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAP
LFWIAANAGLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNAS
SVARMVLTTETVVVDKPAKAEDHDHHHGHAH"
gene complement(3836986..3837288)
/gene="groES"
/gene_synonym="cpn10"
/gene_synonym="mpt57"
/locus_tag="Rv3418c"
CDS complement(3836986..3837288)
/codon_start=1
/transl_table=11
/gene="groES"
/gene_synonym="cpn10"
/gene_synonym="mpt57"
/locus_tag="Rv3418c"
/product="10 kDa chaperonin GroES (protein CPN10) (protein
GroES) (BCG-a heat shock protein) (10 kDa antigen)"
/note="Rv3418c, (MTCY78.11), len: 100 aa. GroES (alternate
gene names: cpn10, mpt57), 10 kDa chaperonin (protein
cpn10) (see citations below), equivalent to
P24301|CH10_MYCLE|MOPB|GROES|CHPA|ML0380|B1620_C3_227|B229
_C3_247 from Mycobacterium leprae (99 aa), FASTA scores:
opt: 568,E(): 2.1e-31, (89.9% identity in 99 aa overlap).
And also strongly identical to others e.g.
O86017|CH10_MYCAV|MOPB|GROES from Mycobacterium avium and
Mycobacterium paratuberculosis (99 aa), FASTA scores: opt:
611, E(): 2.9e-34, (96.95% identity in 99 aa overlap);
P15020|CH10_MYCBO|MOPB|GROES from Mycobacterium bovis (99
aa), FASTA scores: opt: 596, E(): 2.9e-33, (98.95%
identity in 94 aa overlap);
P40172|CH10_STRCO|GROES|SC6G4.39 from Streptomyces
coelicolor and Streptomyces lividans (102 aa),FASTA
scores: opt: 480, E(): 1.6e-25, (76.75% identity in 99 aa
overlap); etc. Also identical to MSG10KAG_1,MT10KAG_1,
MTBCGA_1. Contains PS00681 Chaperonins cpn10 signature.
Belongs to the GROES chaperonin family."
/db_xref="EnsemblGenomes-Gn:Rv3418c"
/db_xref="EnsemblGenomes-Tr:CCP46240"
/db_xref="GOA:P9WPE5"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR018369"
/db_xref="InterPro:IPR020818"
/db_xref="InterPro:IPR037124"
/db_xref="PDB:1HX5"
/db_xref="PDB:1P3H"
/db_xref="PDB:1P82"
/db_xref="PDB:1P83"
/db_xref="UniProtKB/Swiss-Prot:P9WPE5"
/inference="protein motif:PROSITE:PS00681"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46240.1"
/translation="MAKVNIKPLEDKILVQANEAETTTASGLVIPDTAKEKPQEGTVV
AVGPGRWDEDGEKRIPLDVAEGDTVIYSKYGGTEIKYNGEEYLILSARDVLAVVSK"
gene complement(3837555..3838589)
/gene="gcp"
/locus_tag="Rv3419c"
CDS complement(3837555..3838589)
/codon_start=1
/transl_table=11
/gene="gcp"
/locus_tag="Rv3419c"
/product="Probable O-sialoglycoprotein endopeptidase Gcp
(glycoprotease)"
/note="Rv3419c, (MTCY78.10), len: 344 aa. Probable
gcp,glycoprotease, equivalent to
P37969|GCP_MYCLE|GCP|ML0379|U229E|U1620c|B229_C3_246|B1620
_C3_226 probable glycoprotease from Mycobacterium leprae
(351 aa),FASTA scores: opt: 1898, E(): 2.4e-101, (86.1%
identity in 345 aa overlap). Highly similar to others e.g.
O86793|GCP_STRCO|GCP|SC6G4.30 from Streptomyces coelicolor
(374 aa), FASTA scores: opt: 1282, E(): 4.1e-66, (60.45%
identity in 344 aa overlap); Q9WXZ2|TM0145 from Thermotoga
maritima (327 aa), FASTA scores: opt: 867, E():
1.9e-42,(45.4% identity in 337 aa overlap);
P05852|GCP_ECOLI|B3064 from Escherichia coli strain K12
(337 aa), FASTA scores: opt: 838, E(): 9e-41, (46.55%
identity in 346 aa overlap); etc. Shows some similarity to
Q50707|YY21_MYCTU|Rv3421c|MTCY78.08 (33.9% identity in 127
aa overlap). Contains PS01016 Glycoprotease family
signature. Belongs to peptidase family M22; also known as
the glycoprotease family. Conserved in M. tuberculosis, M.
leprae, M. bovis and M. avium paratuberculosis; predicted
to be essential for in vivo survival and pathogenicity
(See Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3419c"
/db_xref="EnsemblGenomes-Tr:CCP46241"
/db_xref="GOA:P9WHT7"
/db_xref="InterPro:IPR000905"
/db_xref="InterPro:IPR017860"
/db_xref="InterPro:IPR017861"
/db_xref="InterPro:IPR022450"
/db_xref="UniProtKB/Swiss-Prot:P9WHT7"
/inference="protein motif:PROSITE:PS01016"
/protein_id="CCP46241.1"
/translation="MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRF
GGVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYS
AAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGST
VDDAAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSG
LKTAVARYVESHAADPGFRTADIAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVA
ANSRLRELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDP
GLPVMQGQVR"
gene complement(3838586..3839062)
/gene="rimI"
/locus_tag="Rv3420c"
CDS complement(3838586..3839062)
/codon_start=1
/transl_table=11
/gene="rimI"
/locus_tag="Rv3420c"
/product="Ribosomal-protein-alanine acetyltransferase RimI
(acetylating enzyme for N-terminal of ribosomal protein
S18)"
/note="Rv3420c, (MTCY78.09), len: 158 aa. Probable
rimI,ribosomal-protein-alanine acetyltransferase, contains
GNAT (Gcn5-related N-acetyltransferase) domain. See
Vetting et al. 2005. Equivalent to C-terminal part of
Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA
protein from Mycobacterium leprae (359 aa), FASTA scores:
opt: 772, E(): 2.7e-44, (72.1% identity in 154 aa
overlap). Similar notably to ribosomal-protein-alanine
acetyltransferases e.g. Q9AC11|CC0058 from Caulobacter
crescentus (150 aa), FASTA scores: opt: 223, E():
4.9e-08,(37.5% identity in 136 aa overlap); Q9KFD4|BH0547
from Bacillus halodurans (151 aa), FASTA scores: opt: 222,
E(): 5.8e-08, (35.2% identity in 142 aa overlap);
Q9PG61|XF0441 from Xylella fastidiosa (156 aa), FASTA
scores: opt: 207,E(): 5.9e-07, (32.2% identity in 149 aa
overlap); Q9HVB7|RIMI|PA4678 from Pseudomonas aeruginosa
(150 aa),FASTA scores: opt: 203, E(): 1.1e-06, (32.45%
identity in 151 aa overlap); P09453|RIMI_ECOLI|B4373 from
Escherichia coli strain K12 (148 aa), FASTA scores: opt:
196, E(): 3.1e-06, (33.55% identity in 149 aa overlap);
etc. Belongs to the acetyltransferase family, RIMI
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3420c"
/db_xref="EnsemblGenomes-Tr:CCP46242"
/db_xref="GOA:I6YG32"
/db_xref="InterPro:IPR000182"
/db_xref="InterPro:IPR006464"
/db_xref="InterPro:IPR016181"
/db_xref="UniProtKB/Swiss-Prot:I6YG32"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46242.1"
/translation="MTADTEPVTIGALTRADAQRCAELEAQLFVGDDPWPPAAFNREL
ASPHNHYVGARSGGTLVGYAGISRLGRTPPFEYEVHTIGVDPAYQGRGIGRRLLRELL
DFARGGVVYLEVRTDNDAALALYRSVGFQRVGLRRRYYRVSGADAYTMRRDSGDPS"
gene complement(3839059..3839694)
/locus_tag="Rv3421c"
CDS complement(3839059..3839694)
/codon_start=1
/transl_table=11
/locus_tag="Rv3421c"
/product="Conserved hypothetical protein"
/note="Rv3421c, (MTCY78.08), len: 211 aa. Conserved
hypothetical protein, equivalent to
Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA
protein from Mycobacterium leprae (359 aa), FASTA scores:
opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa
overlap). Also similar to other hypothetical bacterial
proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor
(217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1%
identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease
family protein) from Caulobacter crescentus (211 aa),
FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210
aa overlap); Q9KQK9|VC1989 from Vibrio cholerae (237
aa),FASTA scores: opt: 238, E(): 8.2e-07, (28.85% identity
in 208 aa overlap); BAB51966|Mlr5530 from Rhizobium loti
(Mesorhizobium loti) (225 aa), FASTA scores: opt: 237,
E(): 9e-07, (35.0% identity in 220 aa overlap); etc. Some
similarity to upstream
Q50709|GCP_MYCTU|Rv3419c|MT3528|MTCY78.10 from
Mycobacterium tuberculosis (344 aa), (33.9% identity in
127 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3421c"
/db_xref="EnsemblGenomes-Tr:CCP46243"
/db_xref="GOA:P9WKY7"
/db_xref="InterPro:IPR000905"
/db_xref="InterPro:IPR022496"
/db_xref="UniProtKB/Swiss-Prot:P9WKY7"
/protein_id="CCP46243.1"
/translation="MSRVQISTVLAIDTATPAVTAGIVRRHDLVVLGERVTVDARAHA
ERLTPNVLAALADAALTMADLDAVVVGCGPGPFTGLRAGMASAAAYGHALGIPVYGVC
SLDAIGGQTIGDTLVVTDARRREVYWARYCDGIRTVGPAVNAAADVDPGPALAVAGAP
EHAALFALPCVEPSRPSPAGLVAAVNWADKPAPLVPLYLRRPDAKPLAVCT"
gene complement(3839691..3840197)
/locus_tag="Rv3422c"
CDS complement(3839691..3840197)
/codon_start=1
/transl_table=11
/locus_tag="Rv3422c"
/product="Conserved hypothetical protein"
/note="Rv3422c, (MTCY78.07), len: 168 aa. Conserved
hypothetical protein, equivalent to
Q49864|YY22_MYCLE|ML0377|U229F|B229_C2_205 hypothetical
17.6 KDA protein from Mycobacterium leprae (161 aa), FASTA
scores: opt: 752, E(): 8.3e-38, (77.4% identity in 146 aa
overlap). Also similar to other hypothetical bacterial
proteins e.g. O86788|YJEE_STRCO|SC6G4.25 from Streptomyces
coelicolor (148 aa), FASTA scores: opt: 377, E():
1.2e-15,(50.85% identity in 120 aa overlap); Q9X1W7|TM1632
from Thermotoga maritima (161 aa), FASTA scores: opt: 247,
E(): 6.2e-08, (39.4% identity in 137 aa overlap);
Q9RRY1|DR2351 from Deinococcus radiodurans (148 aa), FASTA
scores: opt: 236, E(): 2.6e-07, (38.6% identity in 127 aa
overlap); etc. Contains PS00017 ATP /GTP-binding site
motif A."
/db_xref="EnsemblGenomes-Gn:Rv3422c"
/db_xref="EnsemblGenomes-Tr:CCP46244"
/db_xref="GOA:P9WFS7"
/db_xref="InterPro:IPR003442"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WFS7"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP46244.1"
/translation="MSREGIRRRPKARAGLTGGGTATLPRVEDTLTLGSRLGEQLCAG
DVVVLSGPLGAGKTVLAKGIAMAMDVEGPITSPTFVLARMHRPRRPGTPAMVHVDVYR
LLDHNSADLLSELDSLDLDTDLEDAVVVVEWGEGLAERLSQRHLDVRLERVSHSDTRI
ATWSWGRS"
gene complement(3840194..3841420)
/gene="alr"
/locus_tag="Rv3423c"
CDS complement(3840194..3841420)
/codon_start=1
/transl_table=11
/gene="alr"
/locus_tag="Rv3423c"
/product="Alanine racemase Alr"
/note="Rv3423c, (MTCY78.06), len: 408 aa. Alr, alanine
racemase, equivalent to
P38056|ALR_MYCLE|ML0375|B229_C3_243 alanine racemase from
Mycobacterium leprae (388 aa), FASTA scores: opt: 2160,
E(): 2.3e-124, (84.35% identity in 384 aa overlap). Also
highly similar to other alanine racemases e.g.
Q9L888|ALR_MYCAV from Mycobacterium avium (391 aa),FASTA
scores: opt: 2103, E(): 6.8e-121, (83.6% identity in 384
aa overlap); P94967|ALR_MYCSM from Mycobacterium smegmatis
(389 aa), FASTA scores: opt: 1721, E(): 1.3e-97,(67.25%
identity in 385 aa overlap); O86786|ALR_STRCO|SC6G4.23
from Streptomyces coelicolor (391 aa), FASTA scores: opt:
1041, E(): 3.7e-56, (47.65% identity in 380 aa overlap);
etc. Contains Pfam entry PF00842 Alanine racemase. Belongs
to the alanine racemase family."
/db_xref="EnsemblGenomes-Gn:Rv3423c"
/db_xref="EnsemblGenomes-Tr:CCP46245"
/db_xref="GOA:P9WQA9"
/db_xref="InterPro:IPR000821"
/db_xref="InterPro:IPR001608"
/db_xref="InterPro:IPR009006"
/db_xref="InterPro:IPR011079"
/db_xref="InterPro:IPR020622"
/db_xref="InterPro:IPR029066"
/db_xref="PDB:1XFC"
/db_xref="UniProtKB/Swiss-Prot:P9WQA9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46245.1"
/translation="MKRFWENVGKPNDTTDGRGTTSLAMTPISQTPGLLAEAMVDLGA
IEHNVRVLREHAGHAQLMAVVKADGYGHGATRVAQTALGAGAAELGVATVDEALALRA
DGITAPVLAWLHPPGIDFGPALLADVQVAVSSLRQLDELLHAVRRTGRTATVTVKVDT
GLNRNGVGPAQFPAMLTALRQAMAEDAVRLRGLMSHMVYADKPDDSINDVQAQRFTAF
LAQAREQGVRFEVAHLSNSSATMARPDLTFDLVRPGIAVYGLSPVPALGDMGLVPAMT
VKCAVALVKSIRAGEGVSYGHTWIAPRDTNLALLPIGYADGVFRSLGGRLEVLINGRR
CPGVGRICMDQFMVDLGPGPLDVAEGDEAILFGPGIRGEPTAQDWADLVGTIHYEVVT
SPRGRITRTYREAENR"
gene complement(3841714..3842076)
/locus_tag="Rv3424c"
CDS complement(3841714..3842076)
/codon_start=1
/transl_table=11
/locus_tag="Rv3424c"
/product="Hypothetical protein"
/note="Rv3424c, (MTCY78.05), len: 120 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3424c"
/db_xref="EnsemblGenomes-Tr:CCP46246"
/db_xref="UniProtKB/Swiss-Prot:P9WKY3"
/protein_id="CCP46246.1"
/translation="MPNPVTMLYGRKADLVILPHVLAEERPHPYSTPGRKRGAQIALT
TGIDALASFAPQIVNPRHGLSRVVQCLGGCENKRHAYFRSISKTPHIRARGVPSVCAV
RTVGVDGAKRPPKPIPVQ"
gene 3842239..3842769
/gene="PPE57"
/locus_tag="Rv3425"
CDS 3842239..3842769
/codon_start=1
/transl_table=11
/gene="PPE57"
/locus_tag="Rv3425"
/product="PPE family protein PPE57"
/note="Rv3425, (MTCY78.04c), len: 176 aa. PPE57, Member of
the M. tuberculosis PPE family, similar to many e.g.
O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt:
781,E(): 7e-44, (69.9% identity in 176 aa overlap); and
downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232
aa),FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity
in 125 aa overlap); MTV049_11, MTCY428_16,
MTV049_22,MTV049_30, MTCY261_4; etc."
/db_xref="EnsemblGenomes-Gn:Rv3425"
/db_xref="EnsemblGenomes-Tr:CCP46247"
/db_xref="GOA:Q50703"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:Q50703"
/protein_id="CCP46247.1"
/translation="MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESL
EDELDELDENWKGSSSDLLADAVERYLQWLSKHSSQLKHAAWVINGLANAYNDTRRKV
VPPEEIAANREERRRLIASNVAGVNTPAIADLDAQYDQYRARNVAVMNAYVSWTRSAL
SDLPRWREPPQIYRGG"
gene 3843036..3843734
/gene="PPE58"
/locus_tag="Rv3426"
CDS 3843036..3843734
/codon_start=1
/transl_table=11
/gene="PPE58"
/locus_tag="Rv3426"
/product="PPE family protein PPE58"
/note="Rv3426, (MTCY78.03c), len: 232 aa. PPE58, Member of
the M. tuberculosis PPE family, similar to many e.g. the
downstream O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores:
opt: 555, E(): 6.5e-26, (72.0% identity in 125 aa
overlap); and upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c
(176 aa),FASTA scores: opt: 517, E(): 1.1e-23, (68.0%
identity in 125 aa overlap); MTV049_30, MTCY3C7_24,
MTCY428_16,MTCY3A2_22; etc."
/db_xref="EnsemblGenomes-Gn:Rv3426"
/db_xref="EnsemblGenomes-Tr:CCP46248"
/db_xref="GOA:Q50702"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:Q50702"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46248.1"
/translation="MHLMIPAEYISNVIYEGPRADSLYAADQRLRQLADSVRTTAESL
NTTLDELHENWKGSSSEWMADAALRYLDWLSKHSRQILRTARVIESLVMAYEETLLRV
VPPATIANNREEVRRLIASNVAGGKHSSNRRPRGTIRAVPGRKYPSNGPLSKLDPICA
IEAAPMAGAAADPQERVGPRGRRGLAGQQQCRGRPGPSLRCSHDTPRFQMNQAFHTMV
NMLLTCFACQEKPR"
gene complement(3843885..3844640)
/locus_tag="Rv3427c"
CDS complement(3843885..3844640)
/codon_start=1
/transl_table=11
/locus_tag="Rv3427c"
/product="Possible transposase"
/note="Rv3427c, (MTCY78.02), len: 251 aa. Possible
transposase, similar to other e.g. Q9APG8|ORF2 putative
transposase subunit 2 from Pseudomonas putida (251
aa),FASTA scores: opt: 479, E(): 1.8e-21, (34.85% identity
in 238 aa overlap). Contains PS00017 ATP/GTP-binding site
motif A."
/db_xref="EnsemblGenomes-Gn:Rv3427c"
/db_xref="EnsemblGenomes-Tr:CCP46249"
/db_xref="GOA:Q50701"
/db_xref="InterPro:IPR002611"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR028350"
/db_xref="UniProtKB/Swiss-Prot:Q50701"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46249.1"
/translation="MSICDPALRNALRTLKLSGMLDTLDARLAQTRNGDLGHLEFLQA
LREDEIARRESAALTRRLRRAKFEAQATFEDFDFTANPKLPGAMLRDLAALRWLDAGE
SVILHGPVGVGKTHVAQALVHAVARRGGDVRFAKTSRMLSDLAGGHADRSWGQRIREY
TKPLVLILDDFAMREHTAMHADDLYELISDRAITGKPLILTSNRAPNNWYGLFPNPVV
AESLLDRLINTSHQILMDGPSYRPRKRPGRTTS"
mobile_element complement(3843888..3845970)
/mobile_element_type="insertion sequence:IS1532"
/note="IS1532, len: 2083 nt. Insertion sequence IS1532."
gene complement(3844738..3845970)
/locus_tag="Rv3428c"
CDS complement(3844738..3845970)
/codon_start=1
/transl_table=11
/locus_tag="Rv3428c"
/product="Possible transposase"
/note="Rv3428c, (MTCY78.01, len: 410 aa. Possible
transposase insertion sequence, similar to others e.g.
Q9APG9|ORF1 from Pseudomonas putida (509 aa), FASTA
scores: opt: 578, E(): 1.1e-29, (32.45% identity in 376 aa
overlap); P55379|Y4BL_RHISN from Rhizobium sp. strain
NGR234 (516 aa), FASTA scores: opt: 665, E():
2.7e-35,(35.3% identity in 391 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3428c"
/db_xref="EnsemblGenomes-Tr:CCP46250"
/db_xref="GOA:Q50700"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="UniProtKB/Swiss-Prot:Q50700"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46250.1"
/translation="MATIAQRLRDDHGVAASESSVRRWIATHFAEEVARERVTVPRGP
VDAGSEAQIDYGRLGMWFDPATARRVAVWAFVMVLAFSRHLFVRPVIRMDQTAWCACH
VAAFEFFDGVPARLVCDNLRTGVDKPDLYDPQINRSYAELASHYATLVDPARARKPKD
KPRVERPMTYVRDSFWKGREFDSLAQMQQAAVTWSTEVAGLRYLRALEGAQPLRMFEA
VEQQALIALPPRAFELTSWSIGTVGVDTHLKVGKALYSVPWRLIGQRLHARTAGDVVQ
IFAGNDVVATHVRRPSGRSTDFSHYPPEKIAFHMRTPTWCRHTAELVGPASQQVIAEF
MRDNAIHHLRSAQGVLGLRDKHGCDRLEAACARAIEVGDPSYRTIKGILVAGTEHAAN
EPTTSSPASTAGGVPARP"
gene 3847165..3847701
/gene="PPE59"
/locus_tag="Rv3429"
CDS 3847165..3847701
/codon_start=1
/transl_table=11
/gene="PPE59"
/locus_tag="Rv3429"
/product="PPE family protein PPE59"
/note="Rv3429, (MTCY77.01), len: 178 aa. PPE59, Member of
the M. tuberculosis PPE family, similar to many e.g. the
upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176
aa),FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity
in 176 aa overlap); and
Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA
scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa
overlap) (but diverges at 3' end); etc."
/db_xref="EnsemblGenomes-Gn:Rv3429"
/db_xref="EnsemblGenomes-Tr:CCP46251"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHY1"
/protein_id="CCP46251.1"
/translation="MHPMIPAEYISNIIYEGPGADSLSAAAEQLRLMYNSANMTAKSL
TDRLGELQENWKGSSSDLMADAAGRYLDWLTKHSRQILETAYVIDFLAYVYEETRHKV
VPPATIANNREEVHRLIASNVAGVNTPAIAGLDAQYQQYRAQNIAVMNDYQSTARFIL
AYLPRWQEPPQIYGGGGG"
gene complement(3847642..3848805)
/locus_tag="Rv3430c"
CDS complement(3847642..3848805)
/codon_start=1
/transl_table=11
/locus_tag="Rv3430c"
/product="Possible transposase"
/note="Rv3430c, (MTCY77.02c), len: 387 aa. Possible IS1540
transposase, similar to several e.g. Q49592 transposase
from Mycobacterium intracellulare (340 aa), FASTA scores:
opt: 1377, E(): 1.6e-81, (64.2% identity in 338 aa
overlap); similarity is lost at C-terminus due to possible
frameshift after aa 297."
/db_xref="EnsemblGenomes-Gn:Rv3430c"
/db_xref="EnsemblGenomes-Tr:CCP46252"
/db_xref="GOA:I6YC39"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/TrEMBL:I6YC39"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46252.1"
/translation="MIDTAIEEMIPLIGVRAACAATGRAPASYYRAHSKRLSAQSDTF
TSTAVTDPSGPRESAQPRALSAAEREHVLAVLNSQRFADMAPAVVYATLLDEGIYLCS
ESTMYRLLRERGQTGDRRRQATHPAAVKPELVAHQPNSVWSWDITKLRGPAKWSYYYL
YVILDIFSRYVVGWMVASRESKVLAERLIAQTLAAQHISADQLTLHADRGSSMSSKPV
ALLLADLGVTKSHSRPHTSNDNPLSEAQFKTLKYRPDFPKRFESIEAARVHCDRFFGW
YNHEHKHSGIGLHTPADVHYGRADQIRRHRATVLDTAYRDHLERIRSQTTRATRATGL
QRDQPTTEGGPADSINPRKSCLRNVDRFRPGLLDLPAPAPVDLRRLLPSGQIR"
mobile_element complement(3847644..3848806)
/mobile_element_type="insertion sequence:IS1540"
/note="IS1540, len: 1163 nt. Insertion sequence IS1540."
gene complement(3849294..3850139)
/locus_tag="Rv3431c"
CDS complement(3849294..3850139)
/codon_start=1
/transl_table=11
/locus_tag="Rv3431c"
/product="Possible transposase (fragment)"
/note="Rv3431c, (MTCY77.03c), len: 281 aa. Possible
truncated transposase for IS1552, similar to, but shorter
than other transposases e.g. P72303 from Rhodococcus
opacus (418 aa), FASTA scores: opt: 1509, E(): 1.2e-91,
(80.95% identity in 278 aa overlap); Q9AKV5 from
Mycobacterium paratuberculosis (395 aa), FASTA scores:
opt: 1115, E(): 7.8e-66, (63.45% identity in 268 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3431c"
/db_xref="EnsemblGenomes-Tr:CCP46253"
/db_xref="GOA:I6XH73"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/TrEMBL:I6XH73"
/protein_id="CCP46253.1"
/translation="MFAELIRAGLQALIEAEATEAIGAGRYERSDGRIVHRNGHRPKT
VSTTAGDIEVQIPKLRAGSFFPSLLERRRRIDKALHAVIMEAYVHGVSTRSVDDLVAA
MGVQAGVSKSEVSRICAGLDTEIEAFRTRSLTHTEFPYVFCDATFCKVRVGAHVVSQA
LVVATGVSIDGTREVLGTAVGDSESYEFWREFLASLKARGLTGVHLVISDAHAGLKAA
VAQQFSGASWQRCRVHFMRNLYTAVAAKHAPAVTVAVKTIFAHTDPEEVGAQWDRVAD
PLCQP"
mobile_element complement(3849296..3850140)
/mobile_element_type="insertion sequence:IS1552"
/note="IS1552, len: 845 nt. Insertion sequence IS1552."
gene complement(3850372..3851754)
/gene="gadB"
/locus_tag="Rv3432c"
CDS complement(3850372..3851754)
/codon_start=1
/transl_table=11
/gene="gadB"
/locus_tag="Rv3432c"
/product="Probable glutamate decarboxylase GadB"
/note="Rv3432c, (MTCY77.04c), len: 460 aa. Probable
gadB,glutamate decarboxylase, similar to many e.g.
P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803
(467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35%
identity in 457 aa overlap); Q9X8J5|SCE9.23 from
Streptomyces coelicolor (475 aa), FASTA scores: opt:
1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap);
Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA
scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa
overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia)
(500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15%
identity in 437 aa overlap); etc. Belongs to group II
decarboxylases (DDC, gad, HDC and TYRDC)."
/db_xref="EnsemblGenomes-Gn:Rv3432c"
/db_xref="EnsemblGenomes-Tr:CCP46254"
/db_xref="GOA:I6YG46"
/db_xref="InterPro:IPR002129"
/db_xref="InterPro:IPR010107"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015424"
/db_xref="UniProtKB/TrEMBL:I6YG46"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46254.1"
/translation="MSRSHPSVPAHSIAPAYTGRMFTAPVPALRMPDESMDPEAAYRF
IHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPATAAIEARCVSM
VADLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKWRWRQRVGSWKGRMPNLVMG
SNVQVVWEKFCRYFDVEPRYLPMERGRYVITPEQVLAAVDENTIGVVAILGTTYTGEL
EPIAEICAALDKLAAGGGVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGH
KYGLTYPGVGFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLR
LGRDGYTKVMQALSHTARWLGDQLREVDHCEVISDGSAIPVVSFRLAGDRGYTEFDVS
HELRTFGWQVPAYTMPDNATDVAVLRIVVREGLSADLARALHDDAVTALAALDKVKPG
GHFDAQHFAH"
gene complement(3851792..3853213)
/locus_tag="Rv3433c"
CDS complement(3851792..3853213)
/codon_start=1
/transl_table=11
/locus_tag="Rv3433c"
/product="Conserved protein"
/note="Rv3433c, (MTCY77.05), len: 473 aa. Conserved
protein, member of YKL151c/yjeF family, equivalent to
P37391|YY33_MYCLE|ML0373|U229G|B229_C2_201 hypothetical
47.2 KDA protein from Mycobacterium leprae (473 aa), FASTA
scores: opt: 2650, E(): 5e-136, (84.55% identity in 473 aa
overlap). Also similar to other hypothetical bacterial
proteins e.g. Q9X3W3 from Zymomonas mobilis (484 aa),
FASTA scores: opt: 700, E(): 1.2e-30, (33.7% identity in
484 aa overlap); O86783|SC6G4.20c from Streptomyces
coelicolor (485 aa), FASTA scores: opt: 563, E(): 3.2e-23,
(48.45% identity in 489 aa overlap); Q9LC81 from
Arthrobacter sp. Q36 (313 aa), FASTA scores: opt: 553,
E(): 7.9e-23, (44.2% identity in 303 aa overlap); etc.
Contains Pfam match to entry PF01256 hypothetical UPFOO31
family signature and PF03853 YjeF-related protein
N-terminus. Belongs to the UPF0031 family."
/db_xref="EnsemblGenomes-Gn:Rv3433c"
/db_xref="EnsemblGenomes-Tr:CCP46255"
/db_xref="GOA:P9WF11"
/db_xref="InterPro:IPR000631"
/db_xref="InterPro:IPR004443"
/db_xref="InterPro:IPR017953"
/db_xref="InterPro:IPR029056"
/db_xref="InterPro:IPR030677"
/db_xref="InterPro:IPR036652"
/db_xref="UniProtKB/Swiss-Prot:P9WF11"
/inference="protein motif:PROSITE:PS01050"
/inference="protein motif:PROSITE:PS01049"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46255.1"
/translation="MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTA
RTGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKS
GGRLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVA
TGAITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARW
PVPGPRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWP
EVIASPTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPD
LVAGRNAPTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPG
GPVYLNPAGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARASAAAAADP
GPGDAPTSASRISGHIRAALAAL"
gene complement(3853215..3853928)
/locus_tag="Rv3434c"
CDS complement(3853215..3853928)
/codon_start=1
/transl_table=11
/locus_tag="Rv3434c"
/product="Possible conserved transmembrane protein"
/note="Rv3434c, (MTCY77.06c), len: 237 aa. Possible
conserved transmembrane protein, showing some similarity
with Q9CGH7|YLDB hypothetical protein from Lactococcus
lactis (subsp. lactis) (Streptococcus lactis) (258
aa),FASTA scores: opt: 248, E(): 1.6e-09, (28.8% identity
in 198 aa overlap); and P94983|Rv1648|MTCY06H11.13 from
Mycobacterium tuberculosis (268 aa), FASTA scores: opt:
205, E(): 1.2e-06, (31.45% identity in 194 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3434c"
/db_xref="EnsemblGenomes-Tr:CCP46256"
/db_xref="GOA:I6YC44"
/db_xref="UniProtKB/TrEMBL:I6YC44"
/protein_id="CCP46256.1"
/translation="MADASVVARLRSWALAVWHFVSNAPLTYAWLVVLVITTIIQNNL
TGSQLHFVLLHRSTNIAELGRDPLEVLFSSLLWIDGRNLEPYLLLFTLFLAPAEHWLG
HLRWLTVGLTAHIGATYLSEGLLYLAIQHRDASERMVHARDIGVSYFLVGVMAVLTYH
IAKPWRWGYLGVLLVIFGFPLIAMDKAELDFTAVGHFASILIGLLFYPMARERDGRLW
NPARIKSLLHRRGTRGRRA"
gene complement(3853939..3854793)
/locus_tag="Rv3435c"
CDS complement(3853939..3854793)
/codon_start=1
/transl_table=11
/locus_tag="Rv3435c"
/product="Probable conserved transmembrane protein"
/note="Rv3435c, (MTCY77.07c), len: 284 aa. Probable
conserved transmembrane protein, showing some similarity
with P95061|Rv0713|MTCY210.32 hypothetical 33.9 KDA
protein from Mycobacterium tuberculosis (313 aa), FASTA
scores: opt: 557, E(): 1.3e-26, (35.8% identity in 282 aa
overlap); and O32991|MLCB2492.12 from Mycobacterium leprae
(95 aa),FASTA scores: opt: 150, E(): 0.022, (35.3%
identity in 85 aa overlap). Equivalent to AAK47881 from
Mycobacterium tuberculosis strain CDC1551 (312 aa) but
shorter 28 aa."
/db_xref="EnsemblGenomes-Gn:Rv3435c"
/db_xref="EnsemblGenomes-Tr:CCP46257"
/db_xref="GOA:O06252"
/db_xref="InterPro:IPR027948"
/db_xref="UniProtKB/TrEMBL:O06252"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46257.1"
/translation="MGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTAD
GTTVTLHVEQLQTIKGVLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWS
SGSLPGVFPVPLTISGDPANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWN
VDISGVGDANVPAPYRVGLHRSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQ
PPMTTWYAAMLFAVIPLRNALPDAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHL
KPDVDETM"
gene complement(3855015..3856889)
/gene="glmS"
/locus_tag="Rv3436c"
CDS complement(3855015..3856889)
/codon_start=1
/transl_table=11
/gene="glmS"
/locus_tag="Rv3436c"
/product="Probable glucosamine--fructose-6-phosphate
aminotransferase [isomerizing] GlmS (hexosephosphate
aminotransferase) (D-fructose-6-phosphate
amidotransferase) (GFAT)
(L-glutamine-D-fructose-6-phosphate amidotransferase)
(glucosamine-6-phosphate synthase)"
/note="Rv3436c, (MTCY77.08c), len: 624 aa. Probable
glmS,glucosamine--fructose-6-phosphate
aminotransferase,equivalent to
P40831|GLMS_MYCLE|ML0371|B229_C3_238
glucosamine--fructose-6-phosphate aminotransferase
[isomerizing] from Mycobacterium leprae (623 aa), FASTA
scores: opt: 3584, E(): 4.7e-214, (89.3% identity in 627
aa overlap). Also highly similar to others e.g.
O68956|GLMS_MYCSM from Mycobacterium smegmatis (627
aa),FASTA scores: opt: 3517, E(): 6.5e-210, (87.25%
identity in 627 aa overlap); O86781|GLMS_STRCO|SC6G4.18
from Streptomyces coelicolor (614 aa), FASTA scores: opt:
2364,E(): 1.3e-138, (64.95% identity in 625 aa overlap);
Q9K1P9|NMB0031 from Neisseria meningitidis (serogroup B)
and Q9JWN9|GLMS|NMA0276 from Neisseria meningitidis
(serogroup A) (612 aa), FASTA scores: opt: 1445, E():
8.4e-82, (43.55% identity in 627 aa overlap); etc. Belongs
to the type-2 gatase domain in the N-terminal section.
Belongs to the sis family, GLMS subfamily, in the
C-terminal section."
/db_xref="EnsemblGenomes-Gn:Rv3436c"
/db_xref="EnsemblGenomes-Tr:CCP46258"
/db_xref="GOA:P9WN49"
/db_xref="InterPro:IPR001347"
/db_xref="InterPro:IPR005855"
/db_xref="InterPro:IPR017932"
/db_xref="InterPro:IPR029055"
/db_xref="InterPro:IPR035466"
/db_xref="InterPro:IPR035490"
/db_xref="UniProtKB/Swiss-Prot:P9WN49"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46258.1"
/translation="MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTV
RRRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVH
NGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRL
EGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQ
AVVITADGYRISDFDGNDGLQAGRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAV
ADTLLGHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPV
EVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQI
PRECDAVLYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELE
AMPDLVARVIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGALKLKELAYMHAEG
FAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTIVIAEEG
DETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE
"
gene 3856911..3857387
/locus_tag="Rv3437"
CDS 3856911..3857387
/codon_start=1
/transl_table=11
/locus_tag="Rv3437"
/product="Possible conserved transmembrane protein"
/note="Rv3437, (MTCY77.09), len: 158 aa. Questionable ORF.
Possible conserved transmenbrane protein, C-terminus
similar to N-terminal part of O06345|Rv3482c|MTCY13E12.35c
hypothetical 28.5 KDA protein from Mycobacterium
tuberculosis (260 aa), FASTA scores: opt: 140, E():
0.1,(58.8% identity in 34 aa overlap); and
Q9XAN5|SC4C6.05c putative membrane protein from
Streptomyces (347 aa),coelicolor FASTA scores: opt: 112,
E(): 6.8, (50.0% identity in 32 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3437"
/db_xref="EnsemblGenomes-Tr:CCP46259"
/db_xref="GOA:I6YG51"
/db_xref="InterPro:IPR018929"
/db_xref="UniProtKB/TrEMBL:I6YG51"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46259.1"
/translation="MVGRAVPSPNRRYRRVWPPRTKGQHLSNPYAQHQLKLIRHTGAL
ILWQQRTYVVSGTREQCEAAYKSAQTYNLLVGWWSLVSLLAMNWIALISNFNAIRRVR
AAADGASVPHGPHAIAHPAVPRGPIPAGWYPDPSGAGLRYWDGATWTHWTHPPRHR"
gene 3857397..3858239
/locus_tag="Rv3438"
CDS 3857397..3858239
/codon_start=1
/transl_table=11
/locus_tag="Rv3438"
/product="Conserved protein"
/note="Rv3438, (MTCY77.10), len: 280 aa. Conserved
protein,equivalent to Q9CCV6|ML0370 hypothetical protein
from Mycobacterium leprae (289 aa), FASTA scores: opt:
1491,E(): 9.2e-81, (79.85% identity in 283 aa overlap);
and highly similar (but shorter 41 aa) to
Q49872|B229_F1_20 hypothetical 34.0 KDA protein from
Mycobacterium leprae (324 aa), FASTA scores: opt: 1491,
E(): 1e-80, (79.85% identity in 283 aa overlap). Shows
some similarity to Q9KIU3|LIPA lipase from plasmid pAH114
uncultured bacterium (281 aa), FASTA scores: opt: 168,
E(): 0.0081, (29.3% identity in 140 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv3438"
/db_xref="EnsemblGenomes-Tr:CCP46260"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6X7B3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46260.1"
/translation="MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPG
VAFGHDWLTGTSRYSGLLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGV
RLGPGKISVHPAKLGLVGHGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAA
TLDVPGLILTAPGDPKTLTSNALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLP
GPHRRTQRSVRALLTGYLLYTLGGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIV
TLLK"
gene complement(3858259..3859662)
/locus_tag="Rv3439c"
CDS complement(3858259..3859662)
/codon_start=1
/transl_table=11
/locus_tag="Rv3439c"
/product="Conserved hypothetical alanine and proline rich
protein"
/note="Rv3439c, (MTCY77.11c), len: 467 aa. Conserved
hypothetical ala-, pro-rich protein, similar in part to
N-terminal part of Q49853|B229_C1_154 hypothetical 11.2
KDA protein from Mycobacterium leprae (103 aa), FASTA
scores: opt: 265, E(): 0.0013, (51.1% identity in 90 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3439c"
/db_xref="EnsemblGenomes-Tr:CCP46261"
/db_xref="UniProtKB/TrEMBL:I6YC49"
/protein_id="CCP46261.1"
/translation="MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPAQ
IHDWYGSEDGLDLHALDADCAQLRAAASVLMEALRMERSQVAVLAAAWTGSGADAAVH
FVQRHCETGNSVVTEVRAAAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAA
AEALTTEGADRPTAVEVVRQQIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLAS
APRAHFEIPDDLGPGRQPSPASVPAQPSATAAITPAAALPPPDPVPAVTSRPVTPSDF
GSAPGDGSATPAGVGSAGGFGDAGGTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLG
DPLAADNPPGAVDPFAEDAADNADDGDDAHPEEADEAAEPKEATEPDEADEVDDADES
VPAERAQDVAEEATLPPVAEPPPPAAPPVAEPPPPVAAPAPPGAPEPANGPSPEALSE
GATPCEIAADELPQAGP"
gene complement(3859665..3859976)
/locus_tag="Rv3440c"
CDS complement(3859665..3859976)
/codon_start=1
/transl_table=11
/locus_tag="Rv3440c"
/product="Hypothetical protein"
/note="Rv3440c, (MTCY77.12c), len: 103 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3440c"
/db_xref="EnsemblGenomes-Tr:CCP46262"
/db_xref="UniProtKB/TrEMBL:O06257"
/protein_id="CCP46262.1"
/translation="MRPDSVNSAGIDIAAVYAVADRFSAAAELIDDAIGNHLTRLAFG
GACAGRGHASRGDALRCRLDRLAGELSVWSRAAVQIAFALRAGANRYAEADLCAAARI
G"
gene complement(3860024..3861370)
/gene="mrsA"
/locus_tag="Rv3441c"
CDS complement(3860024..3861370)
/codon_start=1
/transl_table=11
/gene="mrsA"
/locus_tag="Rv3441c"
/product="Probable phospho-sugar mutase / MrsA protein
homolog"
/note="Rv3441c, (MTCY77.13c), len: 448 aa. Probable
mrsA,phosphoglucomutase or phosphomannomutase, equivalent
to Q49869|URED|B229_C3_234 MRSA protein homolog from
Mycobacterium leprae (463 aa), FASTA scores: opt:
2449,E(): 6.3e-135, (87.65% identity in 445 aa overlap);
and highly similar (but longer 178 aa) to
Q49862|UREC|B229_C2_192 putative urease operon UREC
protein from Mycobacterium leprae (288 aa), FASTA scores:
opt: 1442, E(): 1.3e-76, (86.5% identity in 267 aa
overlap). Highly similar to phospho-sugar mutases e.g.
Q53876|SC6G4.14 putative phospho-sugar mutase (similar to
phosphomannomutases) from Streptomyces coelicolor (452
aa),FASTA scores: opt: 1710, E(): 5e-92, (60.45% identity
in 450 aa overlap); Q9KG46|BH0267 phosphoglucosamine
mutase from Bacillus halodurans (447 aa), FASTA scores:
opt: 1351,E(): 3.5e-71, (48.4% identity in 444 aa
overlap); BAB58323|GLMM phosphoglucosamine-mutase from
Staphylococcus aureus subsp. aureus Mu50 (451 aa) and
Q99QR5|GLMM(FEMD)|SA1965 phosphoglucosamine-mutase from
Staphylococcus aureus subsp. aureus N315. (451 aa), FASTA
scores: opt: 1315, E(): 4.3e-69, (48.45% identity in 446
aa overlap); P95685|FEMD|GLMM phosphoglucosamine-mutase
(451 aa), FASTA scores: opt: 1310, E(): 8.5e-69, (48.2%
identity in 446 aa overlap); P95575|MRSA_PSESY MRSA
protein homolog from Pseudomonas syringae (pv. syringae)
(447 aa), FASTA scores: opt: 1143, E(): 4.2e-59, (42.75%
identity in 447 aa overlap); etc. Contains PS00710
Phosphoglucomutase and phosphomannomutase phosphoserine
signature. Belongs to the phosphohexose mutases family."
/db_xref="EnsemblGenomes-Gn:Rv3441c"
/db_xref="EnsemblGenomes-Tr:CCP46263"
/db_xref="GOA:P9WN41"
/db_xref="InterPro:IPR005841"
/db_xref="InterPro:IPR005843"
/db_xref="InterPro:IPR005844"
/db_xref="InterPro:IPR005845"
/db_xref="InterPro:IPR005846"
/db_xref="InterPro:IPR006352"
/db_xref="InterPro:IPR016055"
/db_xref="InterPro:IPR016066"
/db_xref="InterPro:IPR036900"
/db_xref="UniProtKB/Swiss-Prot:P9WN41"
/inference="protein motif:PROSITE:PS00710"
/protein_id="CCP46263.1"
/translation="MGRLFGTDGVRGVANRELTAELALALGAAAARRLSRSGAPGRRV
AVLGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTGAYDADFGVMISAS
HNPMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPGLRPAGAGIGRVIDAEDATE
RYLRHVAKAATARLDDLAVVVDCAHGAASSAAPRAYRAAGARVIAINAEPNGRNINDG
CGSTHLDPLRAAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMKEAG
ELACNTLVATVMSNLGLHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIV
MPALGSTGDGIVTGLRLMTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPS
VRTAVEQAAAELGDTGRILLRPSGTEPMIRVMVEAADEGVAQRLAATVADAVSTAR"
gene complement(3861495..3861950)
/gene="rpsI"
/locus_tag="Rv3442c"
CDS complement(3861495..3861950)
/codon_start=1
/transl_table=11
/gene="rpsI"
/locus_tag="Rv3442c"
/product="30S ribosomal protein S9 RpsI"
/note="Rv3442c, (MTCY77.14c), len: 151 aa. rpsI, 30S
ribosomal protein S9, equivalent to
P40828|RS9_MYCLE|ML0365|B229_C2_191 30S ribosomal protein
S9 (153 aa), FASTA scores: opt: 800, E(): 2.1e-42, (83.85%
identity in 155 aa overlap). Also highly similar to others
e.g. Q53875|RS9_STRCO|SC6G4.13 from Streptomyces
coelicolor (170 aa), FASTA scores: opt: 533, E(): 5.7e-26,
(60.75% identity in 135 aa overlap); Q9KGD4|RPSI|BH0169
(BS10) from Bacillus halodurans (130 aa), FASTA scores:
opt: 469, E(): 3.8e-22, (58.65% identity in 121 aa
overlap); Q9CDG7|RPSI from Lactococcus lactis (subsp.
lactis) (Streptococcus lactis) (130 aa), FASTA scores:
opt: 451, E(): 4.9e-21,(58.65% identity in 121 aa
overlap); P07842|RS9_BACST|RPSI from Bacillus
stearothermophilus (129 aa), FASTA scores: opt: 448, E():
7.4e-21, (54.55% identity in 121 aa overlap); etc.
Contains PS00360 Ribosomal protein S9 signature. Belongs
to the S9P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv3442c"
/db_xref="EnsemblGenomes-Tr:CCP46264"
/db_xref="GOA:P9WH25"
/db_xref="InterPro:IPR000754"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR020574"
/db_xref="InterPro:IPR023035"
/db_xref="UniProtKB/Swiss-Prot:P9WH25"
/inference="protein motif:PROSITE:PS00360"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46264.1"
/translation="MTETTPAPQTPAAPAGPAQSFVLERPIQTVGRRKEAVVRVRLVP
GTGKFDLNGRSLEDYFPNKVHQQLIKAPLVTVDRVESFDIFAHLGGGGPSGQAGALRL
GIARALILVSPEDRPALKKAGFLTRDPRATERKKYGLKKARKAPQYSKR"
gene complement(3861947..3862390)
/gene="rplM"
/locus_tag="Rv3443c"
CDS complement(3861947..3862390)
/codon_start=1
/transl_table=11
/gene="rplM"
/locus_tag="Rv3443c"
/product="50S ribosomal protein L13 RplM"
/note="Rv3443c, (MTCY77.15c), len: 147 aa. rplM, 50S
ribosomal protein L13, equivalent to
P38014|RL13_MYCLE|RPLM|ML0364|B229_C3_232 from
Mycobacterium leprae (147 aa), FASTA scores: opt: 917,
E(): 7.5e-53, (91.15% identity in 147 aa overlap). Also
highly similar to others e.g.
Q53874|RL13_STRCO|RPLM|SC6G4.12 from Streptomyces
coelicolor (147 aa), FASTA scores: opt: 668,E(): 1.1e-36,
(65.5% identity in 145 aa overlap);
Q9X1G5|RL13_THEMA|RPLM|TM1454 from Thermotoga maritima
(149 aa), FASTA scores: opt: 536, E(): 4.4e-28, (53.65%
identity in 136 aa overlap);
O67722|RL13_AQUAE|RPLM|AQ_1877 from Aquifex aeolicus (144
aa), FASTA scores: opt: 529, E(): 1.2e-27, (53.2% identity
in 141 aa overlap); etc. Belongs to the L13P family of
ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv3443c"
/db_xref="EnsemblGenomes-Tr:CCP46265"
/db_xref="GOA:P9WHE1"
/db_xref="InterPro:IPR005822"
/db_xref="InterPro:IPR005823"
/db_xref="InterPro:IPR023563"
/db_xref="InterPro:IPR036899"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46265.1"
/translation="MPTYAPKAGDTTRSWYVIDATDVVLGRLAVAAANLLRGKHKPTF
APNVDGGDFVIVINADKVAISGDKLQHKMVYRHSGYPGGLHKRTIGELMQRHPDRVVE
KAILGMLPKNRLSRQIQRKLRVYAGPEHPHSAQQPVPYELKQVAQ"
gene complement(3862624..3862926)
/gene="esxT"
/locus_tag="Rv3444c"
CDS complement(3862624..3862926)
/codon_start=1
/transl_table=11
/gene="esxT"
/locus_tag="Rv3444c"
/product="Putative ESAT-6 like protein EsxT"
/note="Rv3444c, (MTCY77.16c), len: 100 aa. EsxT, ESAT-6
like protein (see citation below), equivalent to
Q9CCV7|ML0363 possible secreted protein from Mycobacterium
leprae (104 aa), FASTA scores: opt: 362, E():
1.1e-18,(71.25% identity in 73 aa overlap). C-terminal
part highly similar to Q49852|B229_C1_150 hypothetical 5.3
KDA protein from Mycobacterium leprae (49 aa), FASTA
scores: opt: 227,E(): 1.4e-09, (68.9% identity in 45 aa
overlap). Seems to belong to the ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv3444c"
/db_xref="EnsemblGenomes-Tr:CCP46266"
/db_xref="GOA:I6YC53"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:I6YC53"
/protein_id="CCP46266.1"
/translation="MNADPVLSYNFDAIEYSVRQEIHTTAARFNAALQELRSQIAPLQ
QLWTREAAAAYHAEQLKWHQAASALNEILIDLGNAVRHGADDVAHADRRAAGAWAR"
gene complement(3862947..3863264)
/gene="esxU"
/locus_tag="Rv3445c"
CDS complement(3862947..3863264)
/codon_start=1
/transl_table=11
/gene="esxU"
/locus_tag="Rv3445c"
/product="ESAT-6 like protein EsxU"
/note="Rv3445c, (MTCY77.17c), len: 105 aa. EsxU, ESAT-6
like protein (see citations below), showing weak
similarity to O30373|VCD|PA2257 pyoverdine biosynthesis
protein from Pseudomonas aeruginosa (215 aa), FASTA
scores: opt: 103,E(): 5.6, (32.35% identity in 133 aa
overlap). Seems to belong to the ESAT6 family. Start
changed since first submission (-20 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3445c"
/db_xref="EnsemblGenomes-Tr:CCP46267"
/db_xref="GOA:I6Y3I6"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:I6Y3I6"
/protein_id="CCP46267.1"
/translation="MSTPNTLNADFDLMRSVAGITDARNEEIRAMLQAFIGRMSGVPP
SVWGGLAAARFQDVVDRWNAESTRLYHVLHAIADTIRHNEAALREAGQIHARHIAAAG
GDL"
gene complement(3863317..3864531)
/locus_tag="Rv3446c"
CDS complement(3863317..3864531)
/codon_start=1
/transl_table=11
/locus_tag="Rv3446c"
/product="Hypothetical alanine and valine rich protein"
/note="Rv3446c, (MTCY77.18c), len: 404 aa. Hypothetical
unknown ala-, val-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv3446c"
/db_xref="EnsemblGenomes-Tr:CCP46268"
/db_xref="InterPro:IPR023840"
/db_xref="UniProtKB/TrEMBL:O06263"
/protein_id="CCP46268.1"
/translation="MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVAL
LDERPVAVDSLWFDALRSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHP
RSWLLRQASSGVSAATVVVEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTR
GITAVVLIDVPSTVAGAAALAAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPA
DPAARPATRSRVPTLARVAAAGVALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTI
PADWSTQRVVSGPGSARVQVTSPADPEVALHVTQSPVPGETLPGTAQRLKRAIDASPA
GVFVDFNPSDIRAGRPAVTYREVRAGHQVRWTILLDGAVRISVGCQSGPGHEDLLREV
CAQAVRSVHAVG"
gene complement(3864528..3868238)
/gene="eccC4"
/locus_tag="Rv3447c"
CDS complement(3864528..3868238)
/codon_start=1
/transl_table=11
/gene="eccC4"
/locus_tag="Rv3447c"
/product="ESX conserved component EccC4. ESX-4 type VII
secretion system protein. Probable membrane protein."
/note="Rv3447c, (MTCY77.19c), len: 1236 aa. EccC4, esx
conserved component, ESX-4 type VII secretion system
protein, probable membrane protein, similar to various
bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP binding
protein from Streptomyces coelicolor (1321 aa), FASTA
scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312
aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor
(1525 aa), FASTA scores: opt: 932, E(): 9.2e-46, (27.2%
identity in 1374 aa overlap); Q9CD30|ML2535 hypothetical
protein from Mycobacterium leprae (1329 aa), FASTA scores:
opt: 910, E(): 1.5e-44, (34.4% identity in 1319 aa
overlap); Q9KE81|BH0975 hypothetical protein from Bacillus
halodurans (1489 aa), FASTA scores: opt: 805, E():
1.9e-38,(25.85% identity in 1292 aa overlap); etc. The
C-terminal region is similar to Q9CDD7|ML0052 (alias
O33086|MLCB628.15c) hypothetical protein from
Mycobacterium leprae (597 aa), FASTA scores: opt: 850,
E(): 2.3e-41,(35.2% identity in 588 aa overlap); and
O6973|Rv3871|MTV027.06 hypothetical protein from
Mycobacterium tuberculosis (591 aa), FASTA scores: opt:
845, E(): 4.3e-41, (35.3% identity in 586 aa overlap).
N-terminal part shows similarity with hypothetical
proteins from Mycobacterium tuberculosis e.g.
O69735|Rv3870|MTV027.05 (747 aa), FASTA scores: opt:
761,E(): 3.6e-36, (38.2% identity in 746 aa overlap).
Equivalent to AAK47893 from Mycobacterium tuberculosis
strain CDC1551 (1200 aa) but longer 36 aa. Contains three
of PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3447c"
/db_xref="EnsemblGenomes-Tr:CCP46269"
/db_xref="GOA:P9WNA7"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR023836"
/db_xref="InterPro:IPR023837"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNA7"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46269.1"
/translation="MNSGPACATADILVAPPPELRRSEPSSLLIRLLPVVMSVATVGV
MVTVFLPGSPATRHPTFLAFPMMMLVSLVVTAVTGRGRRHVSGIHNDRVDYLGYLSVL
RTSVTQTAAAQHVSLNWTHPDPATLWTLIGGPRMWERRPGAADFCRIRVGVGSAPLAT
RLVVGQLPPAQRADPVTRAALRCFLAAHATIADAPIAIPLRVGGPIAIDGDPTKVRGL
LRAMICQLAVWHSPEELLIAGVVSDRNRAHWDWLKWLPHNQHPNACDALGPAPMVYST
LAEMQNALAATVLAHVVAIVDTAERGNGAITGVITIEVGARRDGAPPVVRCAGEVTAL
ACPDQLEPQDALVCARRLAAHRVGHSGRTFIRGSGWAELVGIGDVAAFDPSTLWRNVN
QHDRLRVPIGVTPDGTAVQLDIKEAAEQGMGPHGLCVGATGSGKSELLRTIALGMMAR
NSPEVLNLLLVDFKGGATFLDLAGAPHVAAVITNLAEEAPLVARMQDALAGEMSRRQQ
LLRMAGHLVSVTAYQRARQTGAQLPCLPILFIVVDEFSELLSQHPEFVDVFLAIGRVG
RSLGMHLLLASQRLDEGRLRGLETHLSYRMCLKTWSASESRNVLGTQDAYQLPNTPGA
GLLQTGTGELIRFQTAFVSGPLRRASPSAVHPVAPPSVRPFTTHAAAPVTAGPVGGTA
EVPTPTVLHAVLDRLVGHGPAAHQVWLPPLDEPPMLGALLRDAEPAQAELAVPIGIVD
RPFEQSRVPLTIDLSGAAGNVAVVGAPQTGKSTALRTLIMALAATHDAGRVQFYCLDF
GGGALAQVDELPHVGAVAGRAQPQLASRMLAELESAVRFREAFFRDHGIDSVARYRQL
RAKSAAESFADIFLVIDGWASLRQEFAALEESIVALAAQGLSFGVHVALSAARWAEIR
PSLRDQIGSRIELRLADPADSELDRRQAQRVPVDRPGRGLSRDGMHMVIALPDLDGVA
LRRRSGDPVAPPIPLLPARVDYDSVVARAGDELGAHILLGLEERRGQPVAVDFGRHPH
LLVLGDNECGKTAALRTLCREIVRTHTAARAQLLIVDFRHTLLDVIESEHMSGYVSSP
AALGAKLSSLVDLLQARMPAPDVSQAQLRARSWWSGPDIYVVVDDYDLVAVSSGNPLM
VLLEYLPHARDLGLHLVVARRSGGAARALFEPVLASLRDLGCRALLMSGRPDEGALFG
SSRPMPLPPGRGILVTGAGDEQLVQVAWSPPP"
gene 3868352..3869755
/gene="eccD4"
/locus_tag="Rv3448"
CDS 3868352..3869755
/codon_start=1
/transl_table=11
/gene="eccD4"
/locus_tag="Rv3448"
/product="ESX conserved component EccD4. ESX-4 type VII
secretion system protein. Probable integral membrane
protein."
/note="Rv3448, (MTCY77.20), len: 467 aa. EccD4, esx
conserved component, ESX-4 type VII secretion system
protein, probable integral membrane protein, showing some
similarity with Q9CD35|ML2529 from Mycobacterium leprae
(485 aa), FASTA scores: opt: 371, E(): 3.6e-14, (27.25%
identity in 481 aa overlap); and two proteins from
Mycobacterium tuberculosis O86362|Rv0290|MTV035.18 (472
aa), FASTA scores: opt: 429, E(): 1.6e-17, (28.6% identity
in 479 aa overlap); and O05457|Rv3887c|MTCY15F10.25 (509
aa), FASTA scores: opt: 203, E(): 0.00019, (25.6% identity
in 492 aa overlap). Contains PS00402
Binding-protein-dependent transport systems inner membrane
comp signature."
/db_xref="EnsemblGenomes-Gn:Rv3448"
/db_xref="EnsemblGenomes-Tr:CCP46270"
/db_xref="GOA:P9WNQ1"
/db_xref="InterPro:IPR006707"
/db_xref="InterPro:IPR024962"
/db_xref="UniProtKB/Swiss-Prot:P9WNQ1"
/inference="protein motif:PROSITE:PS00402"
/protein_id="CCP46270.1"
/translation="MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDR
GASPATAARYQLSALGAPALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAV
AAALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAA
GLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAA
TSVLAMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVS
ARMAVLLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGA
IGTAVATHGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVA
ADRALEHGPWIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTA
WLCGAYSAVRHLDLTWT"
gene 3869752..3871119
/gene="mycP4"
/locus_tag="Rv3449"
CDS 3869752..3871119
/codon_start=1
/transl_table=11
/gene="mycP4"
/locus_tag="Rv3449"
/product="Probable membrane-anchored mycosin MycP4 (serine
protease) (subtilisin-like protease) (subtilase-like)
(mycosin-4)"
/note="Rv3449, (MTCY13E12.02), len: 455 aa. Probable
mycP4,membrane-anchored serine protease (mycosin) (see
citation below), similar to hypothetical unknowns or
proteases from Mycobacterium tuberculosis strains H37Rv
and CDC1551 e.g. AAK48366|MT3998 subtilase family protein
from Mycobacterium tuberculosis strain CDC1551 (411 aa),
FASTA scores: opt: 747, E(): 3.5e-33, (45.65% identity in
416 aa overlap); O05461|Rv3883c|MTCY15F10.29
membrane-anchored mycosin MYCP1 (446 aa), FASTA scores:
opt: 747, E(): 3.8e-33, (45.45% identity in 451 aa
overlap); O53695|Rv0291|MTV035.19 probable
membrane-anchored mycosin MYCP2 (461 aa), FASTA scores:
opt: 660, E(): 1.9e-28, (44.0% identity in 457 aa
overlap); etc. And similar to hypothetical proteases from
Mycobacterium leprae e.g. O33076|MLCB628.04|ML0041
hypothetical 45.7 KDA protein (probable secreted protease)
(446 aa), FASTA scores: opt: 683, E(): 1.1e-29, (43.8%
identity in 450 aa overlap); Q9CD36|ML2528 putative
protease (475 aa), FASTA scores: opt: 608, E():
1.3e-25,(43.0% identity in 451 aa overlap); Q9CBV3|ML1538
possible protease (567 aa), FASTA scores: opt: 389, E():
9.7e-14,(33.8% identity in 562 aa overlap); etc. Also some
similarity to other proteases from several organisms e.g.
O31788|APRX alkaline serine protease from Bacillus
subtilis (442 aa), FASTA scores: opt: 296, E(): 8.3e-09,
(29.4% identity in 313 aa overlap); O86650|SC3C3.17c
putative secreted serine protease from Streptomyces
coelicolor (450 aa), FASTA scores: opt: 279, E(): 7e-08,
(33.55% identity in 343 aa overlap); Q9KBJ7|APRX|BH193
intracellular alkaline serine protease from Bacillus
halodurans (444 aa),FASTA scores: opt: 257, E(): 1.1e-06,
(28.65% identity in 335 aa overlap); O86642|SC3C3.08
serine protease from Streptomyces coelicolor (413 aa),
FASTA scores: opt: 243,E(): 5.7e-06, (38.25% identity in
387 aa overlap); etc. Has putative signal peptide at
N-terminus and hydrophobic stretch at C-terminus. Contains
three signatures typical of subtilase family: aspartic
acid active site (PS00136),histidine active site
(PS00137), and serine active site (PS00138). Belongs to
peptidase family S8 (also known as the subtilase family),
pyrolysin subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3449"
/db_xref="EnsemblGenomes-Tr:CCP46271"
/db_xref="GOA:I6YC58"
/db_xref="InterPro:IPR000209"
/db_xref="InterPro:IPR015500"
/db_xref="InterPro:IPR022398"
/db_xref="InterPro:IPR023827"
/db_xref="InterPro:IPR023828"
/db_xref="InterPro:IPR023834"
/db_xref="InterPro:IPR036852"
/db_xref="UniProtKB/Swiss-Prot:I6YC58"
/inference="protein motif:PROSITE:PS00136"
/inference="protein motif:PROSITE:PS00137"
/inference="protein motif:PROSITE:PS00138"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46271.1"
/translation="MTTSRTLRLLVVSALATLSGLGTPVAHAVSPPPIDERWLPESAL
PAPPRPTVQREVCTEVTAESGRAFGRAERSAQLADLDQVWRLTRGAGQRVAVIDTGVA
RHRRLPKVVAGGDYVFTGDGTADCDAHGTLVAGIIAAAPDAQSDNFSGVAPDVTLISI
RQSSSKFAPVGDPSSTGVGDVDTMAKAVRTAADLGASVINISSIACVPAAAAPDDRAL
GAALAYAVDVKNAVIVAAAGNTGGAAQCPPQAPGVTRDSVTVAVSPAWYDDYVLTVGS
VNAQGEPSAFTLAGPWVDVAATGEAVTSLSPFGDGTVNRLGGQHGSIPISGTSYAAPV
VSGLAALIRARFPTLTARQVMQRIESTAHHPPAGWDPLVGNGTVDALAAVSSDSIPQA
GTATSDPAPVAVPVPRRSTPGPSDRRALHTAFAGAAICLLALMATLATASRRLRPGRN
GIAGD"
gene complement(3871084..3872496)
/gene="eccB4"
/locus_tag="Rv3450c"
CDS complement(3871084..3872496)
/codon_start=1
/transl_table=11
/gene="eccB4"
/locus_tag="Rv3450c"
/product="ESX conserved component EccB4. ESX-4 type VII
secretion system protein. Probable membrane protein."
/note="Rv3450c, (MTCY13E12.03c), len: 470 aa. EccB4, esx
conserved component, ESX-4 type VII secretion system
protein, probable membrane protein (possible membrane
spanning region near N-terminus). Similar to hypothetical
unknowns proteins from Mycobacterium leprae e.g.
O33088|MLCB628.17C|ML0054 hypothetical 51.9 KDA protein
(putative membrane protein)(481 aa), FASTA scores: opt:
708, E(): 6.4e-32, (32.9% identity in 480 aa overlap);
Q9CD29|ML2536 (552 aa), FASTA scores: opt: 394, E():
1.7e-14, (33.6% identity in 503 aa overlap); etc. Also
similar to other proteins from Mycobacterium tuberculosis
(strains H37Rv and CDC1551) e.g. O69734|Rv3869|MTV027.04
(480 aa), FASTA scores: opt: 717, E(): 2e-32, (32.55%
identity in 479 aa overlap); O05449|Rv3895c|MTCY15F10.17
(495 aa), FASTA scores: opt: 670, E(): 8.3e-30, (36.4%
identity in 475 aa overlap); O5368|Rv0283|MTV035.11 (538
aa), FASTA scores: opt: 467, E(): 1.5e-18, (36.3% identity
in 493 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3450c"
/db_xref="EnsemblGenomes-Tr:CCP46272"
/db_xref="GOA:P9WNR1"
/db_xref="InterPro:IPR007795"
/db_xref="InterPro:IPR042485"
/db_xref="UniProtKB/Swiss-Prot:P9WNR1"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP46272.1"
/translation="MPSPATTWLHVSGYRFLLRRIECALLFGDVCAATGALRARTTSL
ALGCVLAIVAAMGCAFVALLRPQSALGQAPIVMGRESGALYVRVDDVWHPVLNLASAR
LIAATNANPQPVSESELGHTKRGPLLGIPGAPQLLDQPLAGAESAWAICDSDNGGSTT
VVVGPAEDSSAQVLTAEQMILVATESGSPTYLLYGGRRAVVDLADPAVVWALRLQGRV
PHVVAQSLLNAVPEAPRITAPRIRGGGRASVGLPGFLVGGVVRITRASGDEYYVVLED
GVQRIGQVAADLLRFGDSQGSVNVPTVAPDVIRVAPIVNTLPVSAFPDRPPTPVDGSP
GRAVTTLCVTWTPAQPGAARVAFLAGSGPPVPLGGVPVTLAQADGRGPALDAVYLPPG
RSAYVAARSLSGGGTGTRYLVTDTGVRFAIHDDDVAHDLGLPTAAIPAPWPVLATLPS
GPELSRANASVARDTVAPGP"
gene 3872617..3873405
/gene="cut3"
/gene_synonym="clp3"
/gene_synonym="culp3"
/locus_tag="Rv3451"
CDS 3872617..3873405
/codon_start=1
/transl_table=11
/gene="cut3"
/gene_synonym="clp3"
/gene_synonym="culp3"
/locus_tag="Rv3451"
/product="Probable cutinase precursor Cut3"
/note="Rv3451, (MTCY13E12.04), len: 262 aa. Probable
cut3,cutinase precursor, similar to others e.g. Q9KK87
from Mycobacterium avium (220 aa), FASTA scores: opt: 540,
E(): 3.5e-24, (43.4% identity in 219 aa overlap);
Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia
fuckeliana) (202 aa), FASTA scores: opt: 214, E():
2e-05,(31.45% identity in 210 aa overlap); Q9Y7G8 from
Pyrenopeziza brassicae (203 aa), FASTA scores: opt:
203,E(): 8.5e-05, (31.05% identity in 190 aa overlap);
P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA
scores: opt: 155, E(): 0.054, (31.65% identity in 120 aa
overlap). Similar to other proteins from Mycobacterium
tuberculosis e.g. the downstream ORF
O06319|Rv3452|MTCY13E12.05 hypothetical 23.1 KDA protein
(226 aa), FASTA scores: opt: 775, E(): 1e-37, (58.65%
identity in 220 aa overlap);
Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c probable
cutinase precursor (219 aa), FASTA scores: opt: 565, E():
1.3e-25, (44.85% identity in 223 aa overlap);
Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 probable
cutinase precursor (217 aa), FASTA scores: opt: 489, E():
3e-21, (47.05% identity in 221 aa overlap); etc.
Equivalent to AAK47897 from Mycobacterium tuberculosis
strain CDC1551 (247 aa) but longer 15 aa. Contains
cutinase, serine active site motif (PS00155). Belongs to
the cutinase family. Alternative start possible at 3733.
Start changed since first submission (+15 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3451"
/db_xref="EnsemblGenomes-Tr:CCP46273"
/db_xref="GOA:P9WP39"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR011150"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P9WP39"
/inference="protein motif:PROSITE:PS00155"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46273.1"
/translation="MNNRPIRLLTSGRAGLGAGALITAVVLLIALGAVWTPVAFADGC
PDAEVTFARGTGEPPGIGRVGQAFVDSLRQQTGMEIGVYPVNYAASRLQLHGGDGAND
AISHIKSMASSCPNTKLVLGGYSQGATVIDIVAGVPLGSISFGSPLPAAYADNVAAVA
VFGNPSNRAGGSLSSLSPLFGSKAIDLCNPTDPICHVGPGNEFSGHIDGYIPTYTTQA
ASFVVQRLRAGSVPHLPGSVPQLPGSVLQMPGTAAPAPESLHGR"
gene 3873452..3874132
/gene="cut4"
/gene_synonym="clp4"
/gene_synonym="culp4"
/locus_tag="Rv3452"
CDS 3873452..3874132
/codon_start=1
/transl_table=11
/gene="cut4"
/gene_synonym="clp4"
/gene_synonym="culp4"
/locus_tag="Rv3452"
/product="Probable cutinase precursor Cut4"
/note="Rv3452, (MTCY13E12.05), len: 226 aa. Probable
cut4,cutinase precursor, similar to other e.g. Q9KK87 from
Mycobacterium avium (220 aa), FASTA scores: opt: 522, E():
7.3e-24, (46.6% identity in 221 aa overlap);
P30272|CUTI_MAGGR|CUT1 from Magnaporthe grisea (Rice blast
fungus) (Pyricularia grisea) (228 aa), FASTA scores: opt:
205, E(): 3.8e-05, (29.25% identity in 164 aa overlap);
Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia
fuckeliana) (202 aa), FASTA scores: opt: 204, E():
3.9e-05,(33.5% identity in 209 aa overlap); etc. Similar
to other proteins from Mycobacterium tuberculosis e.g.
upstream ORF O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04
probable cutinase precursor (247 aa), FASTA scores: opt:
773, E(): 1.3e-38, (59.35% identity in 209 aa overlap);
Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c probable
cutinase precursor (219 aa), FASTA scores: opt: 704, E():
1.3e-34, (53.4% identity in 219 aa overlap); etc. Contains
PS00155 Cutinase, serine active site. Belongs to the
cutinase family. Alternative start possible at 4553 in
cSCY13E12 but no RBS."
/db_xref="EnsemblGenomes-Gn:Rv3452"
/db_xref="EnsemblGenomes-Tr:CCP46274"
/db_xref="GOA:O06319"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O06319"
/inference="protein motif:PROSITE:PS00155"
/protein_id="CCP46274.1"
/translation="MIPRPQPHSGRWRAGAARRLTSLVAAAFAAATLLLTPALAPPAS
AGCPDAEVVFARGTGEPPGLGRVGQAFVSSLRQQTNKSIGTYGVNYPANGDFLAAADG
ANDASDHIQQMASACRATRLVLGGYSQGAAVIDIVTAAPLPGLGFTQPLPPAADDHIA
AIALFGNPSGRAGGLMSALTPQFGSKTINLCNNGDPICSDGNRWRAHLGYVPGMTNQA
ARFVASRI"
gene 3874404..3874736
/locus_tag="Rv3453"
CDS 3874404..3874736
/codon_start=1
/transl_table=11
/locus_tag="Rv3453"
/product="Possible conserved transmembrane protein"
/note="Rv3453, (MTCY13E12.06), len: 110 aa. Possible
conserved transmembrane protein, showing weak similarity
with other proteins e.g. Q9F6C3 putative ABC transporter
from Propionibacterium thoenii (424 aa), FASTA scores:
opt: 104, E(): 6.8, (40.6% identity in 69 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3453"
/db_xref="EnsemblGenomes-Tr:CCP46275"
/db_xref="GOA:O06320"
/db_xref="UniProtKB/TrEMBL:O06320"
/protein_id="CCP46275.1"
/translation="MPGVITNSESPTAADHDRITATRETLEDYTLRLAPRSYRRWPPA
VVGISALGGIAYLADFAIGANVGITWGTANALCGIAIFALVVFVTGLPLAYYAARYNI
DLDLIYPR"
gene 3874822..3876090
/locus_tag="Rv3454"
CDS 3874822..3876090
/codon_start=1
/transl_table=11
/locus_tag="Rv3454"
/product="Probable conserved integral membrane protein"
/note="Rv3454, (MTCY13E12.07), len: 422 aa. Probable
conserved integral membrane protein, showing some
similarity to various proteins (generally transporters)
e.g. Q9I5C8|PA0811 probable MFS transporter from
Pseudomonas aeruginosa (415 aa), FASTA scores: opt:
145,E(): 0.13, (28.2% identity in 188 aa overlap);
Q01266|YHYC_PSESN hypothetical protein in HYUC 3'region
(ORF 5) (fragment) from Pseudomonas sp. strain NS671 (245
aa), FASTA scores: opt: 130, E(): 0.75, (24.65% identity
in 134 aa overlap); Q9I242|PA2073 probable transporter
(membrane subunit) from Pseudomonas aeruginosa (476
aa),FASTA scores: opt: 125, E(): 2.5, (24.6% identity in
252 aa overlap); etc. Equivalent to AAK47900 from
Mycobacterium tuberculosis strain CDC1551 (562 aa) but
shorter 140 aa. Contains PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3454"
/db_xref="EnsemblGenomes-Tr:CCP46276"
/db_xref="GOA:O06321"
/db_xref="InterPro:IPR030191"
/db_xref="UniProtKB/TrEMBL:O06321"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP46276.1"
/translation="MAQGLKLGLHIPLWAGYACSTLIIFPLVVYGMKVLSQLQLWTTP
LWLILMAAPFGYLVVSHPDSIGQFFSYAGKDGHGGLSFGSVLLAAGVCLSLIAQIAEQ
IDYLRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQIIGLFLAVYLMANIPGSSTIA
NQPVHQFMQIYRTFVPGWLALTLAVILVVLSQIKINVTNAYSGSLAWTNSFTRLTKHY
PGRVVFLGVNLAIALILMEANMFDFLNTILGCYANCGMAWVVAVASDIGFNKYLLGLS
PKTPEFRRGMLYAINPVGFGSLLLAAGLSIVTFFGGLGAALQPYSPLVAIVTALVMPP
ILAAATKGKYYLRRTHDGIDLPMYDEHGNPSAAVLTCHVCHQDFERPDMLACQTHGAH
VCSLCLSTDKQAEHVLPGLARAHIPGDQVP"
gene complement(3876052..3876822)
/gene="truA"
/locus_tag="Rv3455c"
CDS complement(3876052..3876822)
/codon_start=1
/transl_table=11
/gene="truA"
/locus_tag="Rv3455c"
/product="Probable tRNA pseudouridine synthase a TruA
(pseudouridylate synthase I) (pseudouridine synthase I)
(uracil hydrolyase)"
/note="Rv3455c, (MTCY13E12.08c), len: 256 aa. Probable
truA, pseudouridine synthase A, equivalent to
Q9X796|TRUA_MYCLE|ML1955|MLCB1222.25c tRNA pseudouridine
synthase a from Mycobacterium leprae (249 aa), FASTA
scores: opt: 1345, E(): 3.2e-80, (77.25% identity in 246
aa overlap). Also highly similar to others e.g.
O86776|TRUA_STRCO|SC6G4.09 from Streptomyces coelicolor
(284 aa), FASTA scores: opt: 595, E(): 1.7e-31, (49.8%
identity in 259 aa overlap); Q9RS37|DR2290 from
Deinococcus radiodurans (280 aa), FASTA scores: opt: 383,
E(): 1e-17,(41.2% identity in 216 aa overlap);
Q9PJT0|TRUA_CHLMU|TC0748 from Chlamydia muridarum (267
aa),FASTA scores: opt: 334, E(): 1.5e-14, (37.65% identity
in 231 aa overlap); P07649|TRUA_ECOLI|hist|ASUC|LEUK|B2318
from Escherichia coli strain K12 (270 aa), FASTA scores:
opt: 315, E(): 2.5e-13, (33.35% identity in 240 aa
overlap); etc. Belongs to the TruA family of pseudouridine
synthases."
/db_xref="EnsemblGenomes-Gn:Rv3455c"
/db_xref="EnsemblGenomes-Tr:CCP46277"
/db_xref="GOA:P9WHP9"
/db_xref="InterPro:IPR001406"
/db_xref="InterPro:IPR020095"
/db_xref="InterPro:IPR020097"
/db_xref="InterPro:IPR020103"
/db_xref="UniProtKB/Swiss-Prot:P9WHP9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46277.1"
/translation="MGQRTVAGDLDAALTTIFRTPVRLRAAGRTDAGVHASGQVAHVD
VPADALPNAYPRAGHVGDPEFLPLLRRLGRFLPADVRILDITRAPAGFDARFSALRRH
YVYRLSTAPYGVEPQQARYITAWPRELDLDAMTAASRDLMGLHDFAAFCRHREGATTI
RDLQRLDWSRAGTLVTAHVTADAFCWSMVRSLVGALLAVGEHRRATTWCRELLTATGR
SSDFAVAPAHGLTLIQVDYPPDDQLASRNLVTRDVRSG"
gene complement(3876890..3877432)
/gene="rplQ"
/locus_tag="Rv3456c"
CDS complement(3876890..3877432)
/codon_start=1
/transl_table=11
/gene="rplQ"
/locus_tag="Rv3456c"
/product="50S ribosomal protein L17 RplQ"
/note="Rv3456c, (MTCY13E12.09c), len: 180 aa. rplQ, 50S
ribosomal protein L17, equivalent to
Q9X797|RL17_MYCLE|ML1956|MLCB1222.26c 50S ribosomal
protein L17 from Mycobacterium leprae (170 aa), FASTA
scores: opt: 874, E(): 9.5e-45, (81.85% identity in 171 aa
overlap). Also highly similar to other e.g.
O86775|RL17_STRCO|SC6G4.08 from Streptomyces coelicolor
(168 aa), FASTA scores: opt: 609, E(): 3.7e-29, (60.0%
identity in 170 aa overlap); BAB47931|MLR0326 from
Rhizobium loti (Mesorhizobium loti) (143 aa), FASTA
scores: opt: 404, E(): 3.7e-17, (49.65% identity in 139 aa
overlap); Q9Z9H5|RL17_THETH|RPLQ from Thermus aquaticus
(subsp. thermophilus) (118 aa), FASTA scores: opt:
366,E(): 5.5e-15, (53.15% identity in 111 aa overlap);
P02416|RL17_ECOLI|RPLQ|B3294 from Escherichia coli strain
K12 (127 aa), FASTA scores: opt: 347, E(): 7.6e-14, (50.4%
identity in 119 aa overlap); etc. Belongs to the L17P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv3456c"
/db_xref="EnsemblGenomes-Tr:CCP46278"
/db_xref="GOA:P9WHD3"
/db_xref="InterPro:IPR000456"
/db_xref="InterPro:IPR036373"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WHD3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46278.1"
/translation="MPKPTKGPRLGGSSSHQKAILANLATSLFEHGRITTTEPKARAL
RPYAEKLITHAKKGALHNRREVLKKLRDKDVVHTLFAEIGPFFADRDGGYTRIIKIEA
RKGDNAPMAVIELVREKTVTSEANRARRVAAAQAKAKKAAAMPTEESEAKPAEEGDVV
GASEPDAKAPEEPPAEAPEN"
gene complement(3877464..3878507)
/gene="rpoA"
/locus_tag="Rv3457c"
CDS complement(3877464..3878507)
/codon_start=1
/transl_table=11
/gene="rpoA"
/locus_tag="Rv3457c"
/product="Probable DNA-directed RNA polymerase (alpha
chain) RpoA (transcriptase alpha chain) (RNA polymerase
alpha subunit) (DNA-directed RNA nucleotidyltransferase)"
/note="Rv3457c, (MTCY13E12.10c), len: 347 aa. Probable
rpoA, alpha chain of RNA polymerase, equivalent to
Q9X798|RPOA_MYCLE|ML1957|MLCB1222.27c DNA-directed RNA
polymerase alpha from Mycobacterium leprae (347 aa), FASTA
scores: opt: 2139, E(): 1.3e-123, (95.65% identity in 347
aa overlap). Also highly similar to others e.g.
P72404|RPOA_STRCO|C6G4.07 from Streptomyces coelicolor
(340 aa), FASTA scores: opt: 1672, E(): 4.7e-95, (75.55%
identity in 348 aa overlap); Q9X4V6|RPOA_STRGT from
Streptomyces granaticolor (340 aa), FASTA scores: opt:
1671, E(): 5.4e-95, (75.55% identity in 348 aa overlap);
P20429|RPOA_BACSU from Bacillus subtilis (314 aa), FASTA
scores: opt: 939, E(): 3e-50, (48.9% identity in 311 aa
overlap); etc. Contains (PS00017) ATP/GTP-binding site
motif A (P-loop). Belongs to the RNA polymerase alpha
chain family."
/db_xref="EnsemblGenomes-Gn:Rv3457c"
/db_xref="EnsemblGenomes-Tr:CCP46279"
/db_xref="GOA:P9WGZ1"
/db_xref="InterPro:IPR011260"
/db_xref="InterPro:IPR011262"
/db_xref="InterPro:IPR011263"
/db_xref="InterPro:IPR011773"
/db_xref="InterPro:IPR036603"
/db_xref="InterPro:IPR036643"
/db_xref="PDB:5UH5"
/db_xref="PDB:5UH6"
/db_xref="PDB:5UH8"
/db_xref="PDB:5UH9"
/db_xref="PDB:5UHA"
/db_xref="PDB:5UHB"
/db_xref="PDB:5UHC"
/db_xref="PDB:5UHD"
/db_xref="PDB:5UHE"
/db_xref="PDB:5UHF"
/db_xref="PDB:5UHG"
/db_xref="PDB:5ZX2"
/db_xref="PDB:5ZX3"
/db_xref="PDB:6BZO"
/db_xref="PDB:6C04"
/db_xref="PDB:6C05"
/db_xref="PDB:6C06"
/db_xref="PDB:6DV9"
/db_xref="PDB:6DVB"
/db_xref="PDB:6DVC"
/db_xref="PDB:6DVD"
/db_xref="PDB:6DVE"
/db_xref="PDB:6EDT"
/db_xref="PDB:6EE8"
/db_xref="PDB:6EEC"
/db_xref="PDB:6FBV"
/db_xref="PDB:6JCX"
/db_xref="PDB:6JCY"
/db_xref="UniProtKB/Swiss-Prot:P9WGZ1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46279.1"
/translation="MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLS
SIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGP
GEVTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIG
RIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVEL
FGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELV
ARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEG
AYDEQDYAETEQL"
gene complement(3878659..3879264)
/gene="rpsD"
/locus_tag="Rv3458c"
CDS complement(3878659..3879264)
/codon_start=1
/transl_table=11
/gene="rpsD"
/locus_tag="Rv3458c"
/product="30S ribosomal protein S4 RpsD"
/note="Rv3458c, (MTCY13E12.11c), len: 201 aa. rpsD, 30S
ribosomal protein S4, equivalent to
Q9X799|RS4_MYCLE|RPSD|ML1958|MLCB1222.28c 30S ribosomal
protein S4 from Mycobacterium leprae (201 aa), FASTA
scores: opt: 1271, E(): 2.2e-73, (93.5% identity in 201 aa
overlap); and P45811|RS4_MYCBO|RPSD from Mycobacterium
bovis (131 aa), FASTA scores: opt: 867, E():
4.9e-48,(100.0% identity in 130 aa overlap). Also highly
similar to others e.g. P81288|RS4_BACST|RPSD from Bacillus
stearothermophilus (198 aa), FASTA scores: opt: 665, E():
4e-35, (52.25% identity in 201 aa overlap);
Q9K7Z8|RPSD|BH3209 from Bacillus halodurans (200 aa),
FASTA scores: opt: 626, E(): 1.2e-32, (48.75% identity in
203 aa overlap); Q9X1I3|RS4_THEMA|RPSD|TM1473 from
Thermotoga maritima (209 aa), FASTA scores: opt: 591, E():
2e-30,(45.0% identity in 209 aa overlap); etc. Contains
ribosomal protein S4 signature (PS00632) and ATP/GTP
binding site motif A (PS00017). Belongs to the S4P family
of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv3458c"
/db_xref="EnsemblGenomes-Tr:CCP46280"
/db_xref="GOA:P9WH35"
/db_xref="InterPro:IPR001912"
/db_xref="InterPro:IPR002942"
/db_xref="InterPro:IPR005709"
/db_xref="InterPro:IPR018079"
/db_xref="InterPro:IPR022801"
/db_xref="InterPro:IPR036986"
/db_xref="UniProtKB/Swiss-Prot:P9WH35"
/inference="protein motif:PROSITE:PS00632"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46280.1"
/translation="MARYTGPVTRKSRRLRTDLVGGDQAFEKRPYPPGQHGRARIKES
EYLLQLQEKQKARFTYGVMEKQFRRYYEEAVRQPGKTGEELLKILESRLDNVIYRAGL
ARTRRMARQLVSHGHFNVNGVHVNVPSYRVSQYDIVDVRDKSLNTVPFQIARETAGER
PIPSWLQVVGERQRVLIHQLPERAQIDVPLTEQLIVEYYSK"
gene complement(3879273..3879692)
/gene="rpsK"
/locus_tag="Rv3459c"
CDS complement(3879273..3879692)
/codon_start=1
/transl_table=11
/gene="rpsK"
/locus_tag="Rv3459c"
/product="30S ribosomal protein S11 RpsK"
/note="Rv3459c, (MTCY13E12.12c), len: 139 aa. rpsK, 30S
ribosomal protein S11, equivalent to
Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S ribosomal
protein S11 from Mycobacterium leprae (138 aa), FASTA
scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa
overlap); and P45812|RS11_MYCBO 30S ribosomal protein S11
from Mycobacterium bovis (139 aa), FASTA scores: opt:
867,E(): 8.4e-47, (94.25% identity in 139 aa overlap).
Also highly similar to others e.g.
P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor
(134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85%
identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161
from Bacillus halodurans (129 aa), FASTA scores: opt: 618,
E(): 1.7e-31, (70.3% identity in 128 aa overlap);
P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa),
FASTA scores: opt: 601, E(): 2e-30,(69.0% identity in 129
aa overlap); etc. Contains ribosomal protein S11 signature
(PS00054). Belongs to the S11P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv3459c"
/db_xref="EnsemblGenomes-Tr:CCP46281"
/db_xref="GOA:P9WH65"
/db_xref="InterPro:IPR001971"
/db_xref="InterPro:IPR018102"
/db_xref="InterPro:IPR019981"
/db_xref="InterPro:IPR036967"
/db_xref="UniProtKB/Swiss-Prot:P9WH65"
/inference="protein motif:PROSITE:PS00054"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46281.1"
/translation="MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTI
TDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQDHGVRKVDVFVKGPGSG
RETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV"
gene complement(3879696..3880070)
/gene="rpsM"
/locus_tag="Rv3460c"
CDS complement(3879696..3880070)
/codon_start=1
/transl_table=11
/gene="rpsM"
/locus_tag="Rv3460c"
/product="30S ribosomal protein S13 RpsM"
/note="Rv3460c, (MTCY13E12.13c), len: 124 aa. rpsM, 30S
ribosomal protein S13, equivalent to
Q9X7A1|RS13_MYCLE|RPSM|ML1960|MLCB1222.30c 30S ribosomal
protein S13 from Mycobacterium leprae (124 aa), FASTA
scores: opt: 762, E(): 1.5e-43, (92.75% identity in 124 aa
overlap); and P45813|RS13_MYCBO|RPSM from Mycobacterium
bovis (123 aa), FASTA scores: opt: 727, E(): 3e-41,
(98.25% identity in 114 aa overlap). Also highly similar
to others e.g. O86773|RS13_STRCO|SC6G4.05 from
Streptomyces coelicolor (126 aa), FASTA scores: opt: 631,
E(): 6.2e-35,(73.75% identity in 122 aa overlap);
Q9RA65|RPS13 from Thermus aquaticus (subsp. thermophilus)
(126 aa), FASTA scores: opt: 552, E(): 9.8e-30, (62.6%
identity in 123 aa overlap); P20282|RS13_BACSU|RPSM from
Bacillus subtilis (120 aa), FASTA scores: opt: 533, E():
1.7e-28, (64245% identity in 121 aa overlap); etc.
Contains ribosomal protein S13 signature (PS00646).
Belongs to the S13P family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv3460c"
/db_xref="EnsemblGenomes-Tr:CCP46282"
/db_xref="GOA:P9WH61"
/db_xref="InterPro:IPR001892"
/db_xref="InterPro:IPR010979"
/db_xref="InterPro:IPR018269"
/db_xref="InterPro:IPR019980"
/db_xref="InterPro:IPR027437"
/db_xref="UniProtKB/Swiss-Prot:P9WH61"
/inference="protein motif:PROSITE:PS00646"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46282.1"
/translation="MARLVGVDLPRDKRMEVALTYIFGIGRTRSNEILAATGIDRDLR
TRDLTEEQLIHLRDYIEANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGMPVRGQR
TKTNARTRKGPKRTIAGKKKAR"
gene complement(3880286..3880399)
/gene="rpmJ"
/locus_tag="Rv3461c"
CDS complement(3880286..3880399)
/codon_start=1
/transl_table=11
/gene="rpmJ"
/locus_tag="Rv3461c"
/product="50S ribosomal protein L36 RpmJ"
/note="Rv3461c, (MTCY13E12.14c), len: 37 aa. rpmJ, 50S
ribosomal protein L36, equivalent to
P45810|RL36_MYCBO|RPMJ from Mycobacterium bovis (37 aa);
and Q9X7A2|RL36_MYCLE|RPMJ|ML1961|MLCB1222.31c 50S
ribosomal protein L36 from Mycobacterium leprae (37 aa),
FASTA scores: opt: 241, E(): 9.7e-14, (86.5% identity in
37 aa overlap). Also highly similar to others e.g.
O86772|RL36_STRCO|SC6G4.04 from Streptomyces coelicolor
(37 aa), FASTA scores: opt: 233, E(): 4.5e-13, (83.8%
identity in 37 aa overlap); P07841|RL36_BACST|RPMJ from
Bacillus stearothermophilus (37 aa), FASTA scores: opt:
214, E(): 1.6e-11, (72.95% identity in 37 aa overlap);
P12230|RK36_SPIOL|RPL36 from Spinacia oleracea (Spinach)
(37 aa), FASTA scores: opt: 211, E(): 2.9e-11, (70.25%
identity in 37 aa overlap); etc. Contains PS00828
Ribosomal protein L36 signature. Belongs to the L36P
family of ribosomal proteins."
/db_xref="EnsemblGenomes-Gn:Rv3461c"
/db_xref="EnsemblGenomes-Tr:CCP46283"
/db_xref="GOA:P9WH89"
/db_xref="InterPro:IPR000473"
/db_xref="InterPro:IPR035977"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH89"
/inference="protein motif:PROSITE:PS00828"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46283.1"
/translation="MKVNPSVKPICDKCRLIRRHGRVMVICSDPRHKQRQG"
gene complement(3880432..3880653)
/gene="infA"
/locus_tag="Rv3462c"
CDS complement(3880432..3880653)
/codon_start=1
/transl_table=11
/gene="infA"
/locus_tag="Rv3462c"
/product="Probable translation initiation factor if-1
InfA"
/note="Rv3462c, (MTCY13E12.15c), len: 73 aa. Probable
infA,initiation factor if-1, equivalent to
P45957|ML1962|INFA translation initiation factor if-1 from
Mycobacterium bovis (72 aa) and Mycobacterium leprae (72
aa), FASTA scores: opt: 472, E(): 6.6e-28, (100.0%
identity in 72 aa overlap). Also highly similar to others
e.g. O54209|IF1_STRCO|INFA|SC6G4.03 from Streptomyces
coelicolor (73 aa), FASTA scores: opt: 424, E(): 2e-24,
(84.95% identity in 73 aa overlap);
O50630|IF1_BACHD|INFA|BH0158 from Bacillus halodurans (71
aa), FASTA scores: opt: 388,E(): 8.1e-22, (77.8% identity
in 72 aa overlap); Q9XD14|IF1_LEPIN|INFA from Leptospira
interrogans (71 aa),FASTA scores: opt: 376, E(): 6e-21,
(80.0% identity in 70 aa overlap); etc. Contains 1 'S1
motif' domain. Belongs to the if-1 family."
/db_xref="EnsemblGenomes-Gn:Rv3462c"
/db_xref="EnsemblGenomes-Tr:CCP46284"
/db_xref="GOA:P9WKK3"
/db_xref="InterPro:IPR004368"
/db_xref="InterPro:IPR006196"
/db_xref="InterPro:IPR012340"
/db_xref="PDB:3I4O"
/db_xref="UniProtKB/Swiss-Prot:P9WKK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46284.1"
/translation="MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQH
YIRILPEDRVVVELSPYDLSRGRIVYRYK"
gene 3880907..3881764
/locus_tag="Rv3463"
CDS 3880907..3881764
/codon_start=1
/transl_table=11
/locus_tag="Rv3463"
/product="Conserved protein"
/note="Rv3463, (MTCY13E12.16), len: 285 aa. Conserved
protein, similar to Q9RDA2|SCE20.23 hypothetical 31.4 KDA
protein from Streptomyces coelicolor (290 aa), FASTA
scores: opt: 770, E(): 2.2e-41, (48.6% identity in 247 aa
overlap); and Q9X7Y1|SC6A5.35 putative oxidoreductase from
Streptomyces coelicolor (341 aa), (see blastp
results),FASTA scores: opt: 119, E(): 2.9, (24.1% identity
in 274 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3463"
/db_xref="EnsemblGenomes-Tr:CCP46285"
/db_xref="GOA:I6X7D4"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019922"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:I6X7D4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46285.1"
/translation="MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVG
GSPPAALSWVEPILQATTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGV
GHAEMISEYRKPYNALVEYLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLT
TPEHTARARELIGPSAFLAPEHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLG
FTDDEVSRPGSDRLVDAVVAYGTPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALT
ELAKPLRLT"
gene 3881837..3882832
/gene="rmlB"
/gene_synonym="rfbB"
/locus_tag="Rv3464"
CDS 3881837..3882832
/codon_start=1
/transl_table=11
/gene="rmlB"
/gene_synonym="rfbB"
/locus_tag="Rv3464"
/product="dTDP-glucose 4,6-dehydratase RmlB"
/note="Rv3464, (MTCY13E12.17), len: 331 aa. RmlB
(alternate gene name: rfbB), dTDP-glucose-4,6-dehydratase
(see citations below), nearly identical to Q50556|RMLB
rhamnose biosynthesis protein from Mycobacterium
tuberculosis (329 aa) (previously rfbB, now known as
rmlB). Equivalent to Q9CBH7|RMLB|ML1964 dTDP-glucose
4,6-dehydratase (alias Q9X7A3|RMLB putative dTDP-(glucose
or rhamnose)-4,6-dehydratase (331 aa)) from Mycobacterium
leprae (333 aa), FASTA scores: opt: 1925, E():
1.9e-112,(84.0% identity in 331 aa overlap). Also highly
similar to others e.g. Q9UZH2|RFBB|PAB0785 from Pyrococcus
abyssi (333 aa), FASTA scores: opt: 1115, E(): 4.2e-62,
(51.55% identity in 322 aa overlap); O27817|MTH1789 from
Methanobacterium thermoautotrophicum (336 aa), FASTA
scores: opt: 1104, E(): 2.1e-61, (51.65% identity in 331
aa overlap); BAB60064|TVG0950610 from Thermoplasma
volcanium (318 aa), FASTA scores: opt: 1102, E(): 2.6e-61,
(49.65% identity in 310 aa overlap); etc. Also related to
P72050|MTCY13D12.18|RV3784 hypothetical 36.3 KDA protein
(similar to galactowaldenases from eukaryotic and
prokaryotic origin) from Mycobacterium tuberculosis (326
aa), FASTA scores: E(): 1.4e-26, (33.8% identity in 320 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3464"
/db_xref="EnsemblGenomes-Tr:CCP46286"
/db_xref="GOA:P9WN65"
/db_xref="InterPro:IPR005888"
/db_xref="InterPro:IPR016040"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN65"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46286.1"
/translation="MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESL
ADVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTF
TILEAVRRHGVRLHHISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRA
WVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDD
HNSAVRRILDRGRIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLR
YAIDPSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ"
gene 3882834..3883442
/gene="rmlC"
/gene_synonym="rfbC"
/locus_tag="Rv3465"
CDS 3882834..3883442
/codon_start=1
/transl_table=11
/gene="rmlC"
/gene_synonym="rfbC"
/locus_tag="Rv3465"
/product="dTDP-4-dehydrorhamnose 3,5-epimerase RmlC
(dTDP-4-keto-6-deoxyglucose 3,5-epimerase)
(dTDP-L-rhamnose synthetase) (thymidine
diphospho-4-keto-rhamnose 3,5-epimerase)"
/note="Rv3465, (MTCY13E12.18), len: 202 aa. RmlC
(alternate gene name: rfbC), dTDP-4-dehydrorhamnose
3,5-epimerase (see citations below), nearly identical to
O33170|RMLC RMLC protein from Mycobacterium tuberculosis
(203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5%
identity in 200 aa overlap) (previously known as rfbC).
Equivalent to Q9X7A4|RMLC|ML1965 putative
dTDP-4-dehydrorhamnose 3,5-epimerase from Mycobacterium
leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64,
(75.4% identity in 199 aa overlap). Also highly similar to
others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis
(198 aa), FASTA scores: opt: 671, E(): 7e-38, (51.3%
identity in 193 aa overlap); Q9L6C5 from Streptomyces
antibioticus (202 aa), FASTA scores: opt: 665, E():
1.8e-37, (49.25% identity in 197 aa overlap);
P29783|STRM_STRGR from Streptomyces griseus (200 aa),
FASTA scores: opt: 608, E(): 1.2e-33, (49.25% identity in
201 aa overlap); Q54265|STRM from Streptomyces glaucescens
(200 aa), FASTA scores: opt: 603, E(): 2.5e-33, (46.7%
identity in 197 aa overlap); etc. Also highly similar to
Q9S4D4|TYLJ putative NDP-hexose 3-epimerase from
Streptomyces fradiae (205 aa), FASTA scores: opt: 625,
E(): 8.6e-35, (45.9% identity in 194 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3465"
/db_xref="EnsemblGenomes-Tr:CCP46287"
/db_xref="GOA:P9WH11"
/db_xref="InterPro:IPR000888"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR014710"
/db_xref="PDB:1PM7"
/db_xref="PDB:1UPI"
/db_xref="PDB:2IXC"
/db_xref="UniProtKB/Swiss-Prot:P9WH11"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46287.1"
/translation="MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLD
VRQVNCSVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVL
LDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLV
DGAAPSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT"
gene 3883525..3884193
/locus_tag="Rv3466"
CDS 3883525..3884193
/codon_start=1
/transl_table=11
/locus_tag="Rv3466"
/product="Conserved hypothetical protein"
/note="Rv3466, (MTCY13E12.19), len: 222 aa. Conserved
hypothetical ORF in REP13E12 repeat, but extending 5' of
repeat. Has segment of identity to other REP13E12 ORF's
e.g. MTCY336.16, MTCI65.15c, MTCY09F9.19, cMTCY251.14c.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3466"
/db_xref="EnsemblGenomes-Tr:CCP46288"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P9WKY1"
/protein_id="CCP46288.1"
/translation="MGSGSRERIVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLE
CLVRRLPAVGHALINQLDAQASEEELGGTLCCALANRLRITKPDAARRIADAADLGPR
RALTGEPLAPQLTATATAQRQGLIGEAHVKVIRALFRPPARRGGCVHPPGRRSRPGRQ
SRSISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPS
AGHL"
repeat_region 3883550..3884921
/note="REP-8, len: 1372 nt. REP13E12, copies in
Mycobacterium tuberculosis cosmids: cY336 from 14471 to
15821 (approx. 100% identity); cY251 from 11693 to 13109
(approx. 100% identity); cI65 from 14515 to 15905 (approx
75% identity); cI125 from 27240 to 28597 (approx. 65%
Identity); cY22G8 from 13352 to 14689 (approx. 65%
identity); and cY9F9 from 9019 to 10451 (approx. 65%
identity); also nearly identical to EM_BA :MB35021 U35021
Mycobacterium bovis BCG DNA flanking deletion region 3
from 56 to 1466. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene 3883964..3884917
/locus_tag="Rv3467"
CDS 3883964..3884917
/codon_start=1
/transl_table=11
/locus_tag="Rv3467"
/product="Conserved hypothetical protein"
/note="Rv3467, (MTCY13E12.20), len: 317 aa. Conserved
hypothetical ORF in REP13E12 repeat, identical to ORF's
from other REP13E12 copies e.g. MTCY251.13c,
MTCI65.15c,MTCY09F9.19, cMTCY336.17. Also identical to
Mycobacterium bovis Q50655 hypothetical 34.6 kDa protein
(317 aa) in identical repeat."
/db_xref="EnsemblGenomes-Gn:Rv3467"
/db_xref="EnsemblGenomes-Tr:CCP46289"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/TrEMBL:Q50655"
/protein_id="CCP46289.1"
/translation="MSTRQAAEADLAGKAAQYRPDELARYAQRVMDWLHPDGDLTDTE
RARKRGITLSNQQYDGMSRLSGYLTPQARATFEAVLAKLAAPGATNPDDHTPVIDTTP
DAAAIDRDTRSQAQRNHDGLLAGLRALIASGKLGQHNGLPVSIVVTTTLTDLQTGAGK
GFTGGGTLLPMADVIRMTSHAHHYSPASGRYPQAIFDHGTPLALYHTKRLASPAQRIM
LFANDRGCTKPGCDAPAYHSQAHHVTAWTSTGRTDITELTLACGPDNRLAEKGWTTHN
NTHGHTEWLPPPHLDHGQPRTNTFHHPERFLHNQDDDDKPD"
gene complement(3884975..3886069)
/gene_synonym="rmlB3"
/locus_tag="Rv3468c"
CDS complement(3884975..3886069)
/codon_start=1
/transl_table=11
/gene_synonym="rmlB3"
/locus_tag="Rv3468c"
/product="Possible dTDP-glucose 4,6-dehydratase"
/note="Rv3468c, (MTCY13E12.21c), len: 364 aa. Possible
dTDP-glucose-4,6-dehydratase, but experimental study shown
that the purified protein didn't have dTDP-glucose
dehydratase (rmlB) activity (see Ma et al., 2001). Similar
to others e.g. O08246|MTME from Streptomyces argillaceus
(331 aa), FASTA scores: opt: 238, E(): 1.2e-07, (29.65%
identity in 344 aa overlap); Q9LFG7|F4P12_220 from
Arabidopsis thaliana (Mouse-ear cress) (433 aa), FASTA
scores: opt: 237, E(): 1.8e-07, (27.25% identity in 308 aa
overlap); Q9LZI2|F26K9_260 from Arabidopsis thaliana
(Mouse-ear cress) (445 aa), FASTA scores: opt: 225, E():
1e-06, (25.95% identity in 335 aa overlap); etc. Also
similar to various enzymes and hypothetical unknowns
proteins e.g. BAB48655|MLL1234 UDP-glucose 4-epimerase
from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA
scores: opt: 757, E(): 4.6e-40, (43.4% identity in 302 aa
overlap). First start taken, alternative at 17080 in
cSCYY13E12 suggested by similarity. Note that previously
known as rmlB3 (see Ma et al., 2001)."
/db_xref="EnsemblGenomes-Gn:Rv3468c"
/db_xref="EnsemblGenomes-Tr:CCP46290"
/db_xref="GOA:Q6MWX3"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:Q6MWX3"
/protein_id="CCP46290.1"
/translation="MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSS
GHLGEALVRTLRARGADIVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHH
KPQLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAW
IDESVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRS
QDNIKANEYACRRVALEDAVDAHLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDA
ASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQ
SVHTPLSQLVGSKAYAHSSYHRGVFAPARP"
gene complement(3886073..3887083)
/gene="mhpE"
/locus_tag="Rv3469c"
CDS complement(3886073..3887083)
/codon_start=1
/transl_table=11
/gene="mhpE"
/locus_tag="Rv3469c"
/product="Probable 4-hydroxy-2-oxovalerate aldolase MhpE
(HOA)"
/note="Rv3469c, (MTCY13E12.22c), len: 336 aa. Probable
mhpE, 4-hydroxy-2-oxovalerate aldolase, similar to others
(principally from Pseudomonas species) e.g.
Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338
aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65%
identity in 332 aa overlap); Q9X9Q0|NIKB NIKB protein (see
Bruntner et al., 1999) from Streptomyces tendae (357 aa),
FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in
339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp.
strain KKS102 (352 aa), FASTA scores: opt: 549, E():
9.9e-27,(31.2% identity in 314 aa overlap);
Q51983|CMTG_PSEPU from Pseudomonas putida (350 aa), FASTA
scores: opt: 543, E(): 2.3e-26, (30.7% identity in 319 aa
overlap); P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia
coli strain K12 (337 aa), FASTA scores: opt: 517, E():
9.1e-25, (31.75% identity in 312 aa overlap); etc. Also
similar to P71867|MTCY03C7.22|Rv3534c hypothetical 36.4
KDA protein from Mycobacterium tuberculosis (346 aa),
FASTA scores: E(): 7.5e-24, (31.9% identity in 310 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3469c"
/db_xref="EnsemblGenomes-Tr:CCP46291"
/db_xref="GOA:O06334"
/db_xref="InterPro:IPR000891"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:O06334"
/protein_id="CCP46291.1"
/translation="MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAG
IPYIEIGHGVTIGAAAAQGPAAHTDEEYFRAARSVVRNARLGAVIVPALARIETVDLA
GDYLDFLRICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDV
GVRIVYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGAD
FLDGTLMGFGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGID
PWEISFGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGM
RA"
gene complement(3887144..3888802)
/gene="ilvB2"
/locus_tag="Rv3470c"
CDS complement(3887144..3888802)
/codon_start=1
/transl_table=11
/gene="ilvB2"
/locus_tag="Rv3470c"
/product="Probable acetolactate synthase (large subunit)
IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit)
(ALS)"
/note="Rv3470c, (MTCY13E12.23c), len: 552 aa. Probable
ilvB2, acetolactate synthase large subunit, similar to
others e.g. P73913|ILVG|SLR2088 from Synechocystis sp.
strain PCC 6803 (621 aa), FASTA scores: opt: 779, E():
4.5e-39, (30.7% identity in 567 aa overlap);
O78518|ILVB_GUITH from Guillardia theta (Cryptomonas phi)
(575 aa), FASTA scores: opt: 742, E(): 6.9e-37, (28.8%
identity in 566 aa overlap); Q59950|ILVX from Spirulina
platensis (612 aa), FASTA scores: opt: 715, E():
3e-35,(28.45% identity in 569 aa overlap); etc. Contains
thiamine pyrophosphate enzymes signature (PS00187)."
/db_xref="EnsemblGenomes-Gn:Rv3470c"
/db_xref="EnsemblGenomes-Tr:CCP46292"
/db_xref="GOA:O06335"
/db_xref="InterPro:IPR000399"
/db_xref="InterPro:IPR011766"
/db_xref="InterPro:IPR012000"
/db_xref="InterPro:IPR012001"
/db_xref="InterPro:IPR029035"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/Swiss-Prot:O06335"
/inference="protein motif:PROSITE:PS00187"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46292.1"
/translation="MTVGDHLVARMRAAGISVVCGLPTSRLDSLLVRLSRDAGFQIVL
ARHEGGAGYLADGFARASGKSAAVFVAGPGATNVISAVANASVNQVPMLILTGEVAVG
EFGLHSQQDTSDDGLGLGATFRRFCRCSVSIESIANARSKIDSAFRALASIPRGPVHI
ALPRDLVDERLPAHQLGTAAAGLGGLRTLAPCGPDVADEVIGRLDRSRAPMLVLGNGC
RLDGIGEQIVAFCEKAGLPFATTPNGRGIVAETHPLSLGVLGIFGDGRADEYLFDTPC
DLLIAVGVSFGGLVTRSFSPRWRGLKADVVHVDPDPSAVGRFVATSLGITTSGRAFVN
ALNCGRPPRFCRRVGVRPPAPAALPGTPQARGESIHPLELMHELDRELAPNATICADV
GTCISWTFRGIPVRRPGRFFATVDFSPMGCGIAGAIGVALARPEEHVICIAGDGAFLM
HGTEISTAVAHGIRVTWAVLNDGQMSASAGPVSGRMDPSPVARIGANDLAAMARALGA
EGIRVDTRCELRAGVQKALAATGPCVLDIAIDPEINKPDIGLGR"
gene complement(3888808..3889341)
/locus_tag="Rv3471c"
CDS complement(3888808..3889341)
/codon_start=1
/transl_table=11
/locus_tag="Rv3471c"
/product="Conserved hypothetical protein"
/note="Rv3471c, (MTCY13E12.24c), len: 177 aa. Conserved
hypothetical protein, similar to Q59013|MJ1618
hypothetical protein from Methanococcus jannaschii (125
aa), FASTA scores: opt: 262, E(): 1.2e-09, (39.05%
identity in 105 aa overlap); and O26452|MTH352 conserved
protein from Methanobacterium thermoautotrophicum (131
aa), FASTA scores: opt: 222, E(): 3.8e-07, (35.05%
identity in 117 aa overlap). Equivalent to AAK47934 from
Mycobacterium tuberculosis strain CDC1551 (184 aa) but
shorter 7 aa."
/db_xref="EnsemblGenomes-Gn:Rv3471c"
/db_xref="EnsemblGenomes-Tr:CCP46293"
/db_xref="GOA:O06336"
/db_xref="InterPro:IPR006045"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR013096"
/db_xref="InterPro:IPR014710"
/db_xref="UniProtKB/TrEMBL:O06336"
/protein_id="CCP46293.1"
/translation="MSTRPERERASTSTDAVLQATVALSAGHKPAFRGFVKDPPRARA
HAAAMFVSNAREAEPFVAPDLSEIRVLVDRATVGVASVSLAHATVAAGAETVWHRLQA
TDEIYFVLSGRGLVSVGDESGEVGPGDAVWIPAGVPQKIRALGSVPLTFLCACGPAYL
PERDQRMGEAAVIGAWP"
gene 3889362..3889868
/locus_tag="Rv3472"
CDS 3889362..3889868
/codon_start=1
/transl_table=11
/locus_tag="Rv3472"
/product="Conserved protein"
/note="Rv3472, (MTCY13E12.25), len: 168 aa. Conserved
protein, showing some similarity to other proteins e.g.
Q9ZAT9|DPSH daunorubicin biosynthesis enzyme from
Streptomyces peucetius (194 aa), FASTA scores: opt:
181,E(): 6.8e-05, (30.7% identity in 127 aa overlap);
Q53879 DAUH/E from Streptomyces sp. C5 (151 aa), FASTA
scores: opt: 168, E(): 0.00038, (29.25% identity in 127 aa
overlap); and Q9L4U3|AKNV from Streptomyces galilaeus (144
aa), FASTA scores: opt: 122, E(): 0.36, (31.25% identity
in 129 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3472"
/db_xref="EnsemblGenomes-Tr:CCP46294"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/TrEMBL:I6YG83"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46294.1"
/translation="MRPVDEQWIEILRIQALCARYCLTIDTQDGEGWAGCFTEDGAFE
FDGWVIRGRPALREYADAHARVVRGRHLTTDLLYEVDGDVATGRSASVVTLATAAGYK
ILGSGEYQDRLIKQDGQWRIAYRRLRNDRLVSDPSVAVNVADADVAAVVGHLLAAARR
LGTQMSDT"
gene complement(3889948..3890733)
/gene="bpoA"
/locus_tag="Rv3473c"
CDS complement(3889948..3890733)
/codon_start=1
/transl_table=11
/gene="bpoA"
/locus_tag="Rv3473c"
/product="Possible peroxidase BpoA (non-haem peroxidase)"
/note="Rv3473c, (MTCY13E12.26c), len: 261 aa. Possible
bpoA, peroxidase (non-haem peroxidase), similar to various
enzymes or hypothetical unknown proteins e.g. O85849
hypothetical 26.2 KDA protein from Sphingomonas
aromaticivorans (247 aa), FASTA scores: opt: 684, E():
4.9e-34, (43.8% identity in 242 aa overlap);
AAK45412|MT1155 hydrolase, alpha/beta hydrolase fold
family from Mycobacterium tuberculosis strain CDC1551 (311
aa),FASTA scores: opt: 675, E(): 2e-33, (39.45% identity
in 256 aa overlap); Q9K3V0|SCD10.27 putative hydrolase
from Streptomyces coelicolor (352 aa), FASTA scores: opt:
248,E(): 9.7e-08, (26.05% identity in 261 aa overlap);
P29715|BPA2_STRAU|BPOA2 non-haem bromoperoxidase (bromide
peroxidase) (277 aa), FASTA scores: opt: 237, E():
3.6e-07,(29.45% identity in 265 aa overlap);
O31168|PRXC_STRAU|CPO|CPOT non-heme chloroperoxidase (278
aa), FASTA scores: opt: 236, E(): 4.2e-07, (29.45%
identity in 265 aa overlap); AAK62388|T5L19.180
lipase-like protein from Arabidopsis thaliana (Mouse-ear
cress) (350 aa), FASTA scores: opt: 236, E(): 5.1e-07,
(26.65% identity in 274 aa overlap); etc. Also similar to
O06575|BPOB|Rv1123c|MTCY22G8.12c hypothetical 32.5 KDA
protein from Mycobacterium tuberculosis (302 aa), FASTA
scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa
overlap). Equivalent to AAK47936 from Mycobacterium
tuberculosis strain CDC1551 (294 aa) but shorter 33 aa.
May have been inactivated or truncated by neighbouring
IS6110."
/db_xref="EnsemblGenomes-Gn:Rv3473c"
/db_xref="EnsemblGenomes-Tr:CCP46295"
/db_xref="GOA:O06338"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:O06338"
/protein_id="CCP46295.1"
/translation="MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSE
GDYRLVSFAGDIQEVLRNLPGQPALVGASLGGFAAMLLAGELSPGIASAVVLVDIVPN
MDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRRGDRW
YWHWDPQFIGGIAAFPPVEVTDVDRMNAAVATILRDEVPVLLVRGQVSDIVRQESADQ
FLSRFPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR"
mobile_element 3890779..3892133
/mobile_element_type="insertion sequence:IS6110-16"
/note="IS6110-16, len: 1355 nt. Insertion sequence
IS6110."
repeat_region 3890779..3890806
/note="28 bp inverted repeat at left end of IS6110
:TGAACCGCCCCGGCATGTCCGGAGACTC"
gene 3890830..3891156
/locus_tag="Rv3474"
CDS 3890830..3891156
/codon_start=1
/transl_table=11
/locus_tag="Rv3474"
/product="Possible transposase for insertion element
IS6110 (fragment)"
/note="Rv3474, (MTCY13E12.27), len: 108 aa. Probable
transposase subunit for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv3474 and Rv3475, the
sequence UUUUAAAG (directly upstream of Rv3475) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Belongs to the transposase family 8."
/db_xref="EnsemblGenomes-Gn:Rv3474"
/db_xref="EnsemblGenomes-Tr:CCP46296"
/db_xref="GOA:P9WKH5"
/db_xref="InterPro:IPR002514"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/Swiss-Prot:P9WKH5"
/protein_id="CCP46296.1"
/translation="MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGV
GCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAE
LDRPAR"
gene <3891105..3892091
/locus_tag="Rv3475"
CDS <3891105..3892091
/codon_start=1
/transl_table=11
/locus_tag="Rv3475"
/product="Possible transposase for insertion element
IS6110 [second part]"
/note="Rv3475, (MTCY13E12.28), len: 328 aa. Probable
transposase subunit for IS6110. Identical to many other M.
tuberculosis IS6110 transposase subunits. The transposase
described here may be made by a frame shifting mechanism
during translation that fuses Rv3474 and Rv3475, the
sequence UUUUAAAG (directly upstream of Rv3475) maybe
responsible for such a frameshifting event (see McAdam et
al., 1990). Start changed since first submission (- 18
aa)."
/db_xref="EnsemblGenomes-Gn:Rv3475"
/db_xref="EnsemblGenomes-Tr:CCP46297"
/db_xref="GOA:P9WKH9"
/db_xref="InterPro:IPR001584"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR025948"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR038965"
/db_xref="UniProtKB/Swiss-Prot:P9WKH9"
/protein_id="CCP46297.1"
/translation="KDRVGFLRGRARPASTLITRFIADHQGHREGPDGLRWGVESICT
QLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNR
EGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWV
ADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLD
LKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKP
GKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG"
repeat_region complement(3892106..3892133)
/note="28 bp inverted repeat at right end of IS6110
:TGAACCGCCCCGGTGAGTCCGGAGACTC"
gene complement(3892371..3893720)
/gene="kgtP"
/locus_tag="Rv3476c"
CDS complement(3892371..3893720)
/codon_start=1
/transl_table=11
/gene="kgtP"
/locus_tag="Rv3476c"
/product="Probable dicarboxylic acid transport integral
membrane protein KgtP (dicarboxylate transporter)"
/note="Rv3476c, (MTCY13E12.29c), len: 449 aa. Probable
kgtP, dicarboxylate-transport integral membrane
protein,possibly member of major facilitator superfamily
(MFS),highly similar to others e.g. Q9HT43|PA5530 from
Pseudomonas aeruginosa (435 aa), FASTA scores: opt:
1209,E(): 2.3e-68, (47.05% identity in 425 aa overlap);
Q9I6Q9|PCAT|PA0229 from Pseudomonas aeruginosa (432
aa),FASTA scores: opt: 1131, E(): 1.8e-63, (40.4% identity
in 438 aa overlap); Q9WWZ2 from Pseudomonas putida (429
aa),FASTA scores: opt: 1090, E(): 6.5e-61, (41.2% identity
in 425 aa overlap); P17448|KGTP_ECOLI|WITA|B2587 from
Escherichia coli strain K12 (432 aa), FASTA scores: opt:
1083, E(): 1.8e-60, (40.05% identity in 422 aa overlap);
etc. Also similar to O05301|MTCI364.12|Rv1200 hypothetical
44.6 KDA protein from Mycobacterium tuberculosis (425
aa),FASTA scores: E(): 5.2e-25, (28.5% identity in 382 aa
overlap). Contains sugar transport protein signatures 1
and 2 (PS00216, PS00217). Belongs to the sugar transporter
family."
/db_xref="EnsemblGenomes-Gn:Rv3476c"
/db_xref="EnsemblGenomes-Tr:CCP46298"
/db_xref="GOA:I6XHB8"
/db_xref="InterPro:IPR005828"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:I6XHB8"
/inference="protein motif:PROSITE:PS00216"
/inference="protein motif:PROSITE:PS00217"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46298.1"
/translation="MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFA
TYFEDQFFDRADRNSTVYVYAIFAVTFVTRPVGSWFLGRFADRRGRRAALTFSVSLMA
ACSLIVALVPSRSSIGVAAPILLILCRLVQGFATGGEYGTSATYMSEAATRERRGYFS
SFQYVTLVGGHVLAQFTLLVILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDE
SLSQERLTAIKAGRDHDSGSLRELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVK
SVYGSQAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWFGVGGLIYTYVLVTY
LPETRSPTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVGVGYALANSVFGG
TAPLIYQALKERDQVPMFIAYVTACIAVSLIVYVFFIKNKADTYLDREQGFAFYGHA"
gene 3894093..3894389
/gene="PE31"
/locus_tag="Rv3477"
CDS 3894093..3894389
/codon_start=1
/transl_table=11
/gene="PE31"
/locus_tag="Rv3477"
/product="PE family protein PE31"
/note="Rv3477, (MTCY13E12.30), len: 98 aa. PE31, Member of
the Mycobacterium tuberculosis PE family (see Brennan &
Delogu 2002), similar to O53941|Rv1791|MTV049.13 (99
aa),FASTA scores: opt: 373, E(): 4.3e-18, (64.65% identity
in 99 aa overlap); MTCI364.07; MTCY21C12.10c;
MTCY1A11.25c; MTC1A11.04; MTCY359.33; etc."
/db_xref="EnsemblGenomes-Gn:Rv3477"
/db_xref="EnsemblGenomes-Tr:CCP46299"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:I6YG87"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46299.1"
/translation="MSFTAQPEMLAAAAGELRSLGATLKASNAAAAVPTTGVVPPAAD
EVSLLLATQFRTHAATYQTASAKAAVIHEQFVTTLATSASSYADTEAANAVVTG"
gene 3894426..3895607
/gene="PPE60"
/gene_synonym="mtb39c"
/locus_tag="Rv3478"
CDS 3894426..3895607
/codon_start=1
/transl_table=11
/gene="PPE60"
/gene_synonym="mtb39c"
/locus_tag="Rv3478"
/product="PE family protein PPE60"
/note="Rv3478, (MTCY13E12.31), len: 393 aa. PPE60
(alternate gene name: mtb39c). Member of the M.
tuberculosis PPE family, highly similar to others e.g.
Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396
aa),FASTA scores: opt: 2165, E(): 1.1e-109, (85.35%
identity in 396 aa overlap); MTCI364.08; MTCY10G2.10;
MTCY03A2.22c; MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc.
Note that expression of Rv3478 was demonstrated in lysates
by immunodetection (see Dillon et al., 1999)."
/db_xref="EnsemblGenomes-Gn:Rv3478"
/db_xref="EnsemblGenomes-Tr:CCP46300"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q6MWX1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46300.1"
/translation="MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAAS
AFQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAY
RLTVPPPVIAENRTELMTLTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAA
TATEALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGV
VPSSKLGGLWTAVSPHLSPLSNVSSIANNHMSMMGTGVSMTNTLHSMLKGLAPAAAQA
VETAAENGVWAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAV
TPAARALPLTSLTSAAQTAPGHMLGGLPLGHSVNAGSGINNALRVPARAYAIPRTPAA
G"
gene 3895820..3898885
/locus_tag="Rv3479"
CDS 3895820..3898885
/codon_start=1
/transl_table=11
/locus_tag="Rv3479"
/product="Possible transmembrane protein"
/note="Rv3479, (MTCY13E12.32), len: 1021 aa. Possible
transmembrane protein, with hydrophobic stretches at
C-terminus. Start changed since first submission (-54 aa).
Alternative nucleotide at position 3896340 (T->G; L174R)
has been observed."
/db_xref="EnsemblGenomes-Gn:Rv3479"
/db_xref="EnsemblGenomes-Tr:CCP46301"
/db_xref="GOA:O06342"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR019894"
/db_xref="InterPro:IPR024282"
/db_xref="UniProtKB/Swiss-Prot:O06342"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46301.1"
/translation="MAGVTREINLLAQASQWRRLGGTFPTNSQLTNESAASLRLYAQL
IDLLDMVVDVDILSGTSAGGINAALLASSRVTGSDLGGIRDLWLDLGALTELLRDPRD
KKTPSLLYGDERIFAALAKRLPKLATGPFPPTTFPEAARTPSTTLYITTTLLAGETSR
FTDSFGTLVQDVDLRGLFTFTETDLARPDTAPALALAARSSASFPLAFEPSFLPFTKG
TAKKGEVPARPAMAPFTSLTRPHWVSDGGLLDNRPIGVLFKRIFDRPARRPVRRVLLF
VVPSSGPAPDPMHEPPPDNVDEPLGLIDGLLKGLAAVTTQSIAADLRAIRAHQDCMEA
RTDAKLRLAELAATLRNGTRLLTPSLLTDYRTREATKQAQTLTSALLRRLSTCPPESG
PATESLPKSWSAELTVGGDADKVCRQQITATILLSWSQPTAQPLPQSPAELARFGQPA
YDLAKGCALTVIRAAFQLARSDADIAALAEVTEAIHRAWRPTASSDLSVLVRTMCSRP
AIRQGSLENAADQLAADYLQQSTVPGDAWERLGAALVNAYPTLTQLAASASADSGAPT
DSLLARDHVAAGQLETYLSYLGTYPGRADDSRDAPTMAWKLFDLATTQRAMLPADAEI
EQGLELVQVSADTRSLLAPDWQTAQQKLTGMRLHHFGAFYKRSWRANDWMWGRLDGAG
WLVHVLLDPRRVRWIVGERADTNGPQSGAQWFLGKLKELGAPDFPSPGYPLPAVGGGP
AQHLTEDMLLDELGFLDDPAKPLPASIPWTALWLSQAWQQRVLEEELDGLANTVLDPQ
PGKLPDWSPTSSRTWATKVLAAHPGDAKYALLNENPIAGETFASDKGSPLMAHTVAKA
AATAAGAAGSVRQLPSVLKPPLITLRTLTLSGYRVVSLTKGIARSTIIAGALLLVLGV
AAAIQSVTVFGVTGLIAAGTGGLLVVLGTWQVSGRLLFALLSFSVVGAVLALATPVVR
EWLFGTQQQPGWVGTHAYWLGAQWWHPLVVVGLIALVAIMIAAATPGRR"
gene complement(3898909..3900402)
/locus_tag="Rv3480c"
CDS complement(3898909..3900402)
/codon_start=1
/transl_table=11
/locus_tag="Rv3480c"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv3480c, (MTCY13E12.33c), len: 497 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004),
similar to many from Mycobacterium tuberculosis strains
H37Rv and CDC1551 e.g.
O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa),
FASTA scores: opt: 520, E(): 2e-23, (39.95% identity in
488 aa overlap); Q10554|Y895_MYCTU|Rv0895|MTCY31.23 (505
aa), FASTA scores: opt: 434, E(): 2.7e-18, (34.2% identity
in 497 aa overlap); AAK45165|MT0919 (520 aa), FASTA
scores: opt: 434, E(): 2.7e-18, (34.2% identity in 497 aa
overlap); etc. Also similar to Q9X7A8|MLCB1610.05|ML1244
conserved membrane protein from Mycobacterium leprae (491
aa), FASTA scores: opt: 272, E(): 1e-08, (28.85% identity
in 485 aa overlap); and Q9RIU8|CM11.13c hypothetical 47.1
KDA protein from Streptomyces coelicolor (446 aa), FASTA
scores: opt: 254,E(): 1.1e-07, (30.4% identity in 497 aa
overlap). Seems to belong to the UPF0089 family."
/db_xref="EnsemblGenomes-Gn:Rv3480c"
/db_xref="EnsemblGenomes-Tr:CCP46302"
/db_xref="GOA:P9WKA7"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="UniProtKB/Swiss-Prot:P9WKA7"
/protein_id="CCP46302.1"
/translation="MSQTARRLGPQDMFFLYSESSTTMMHVGALMPFTPPSGAPPDLL
RQLVDESKASEVVEPWSLRLSHPELLYHPTQSWVVDDNFDLDYHVRRSALASPGDERE
LGIPVSRLHSHALDLRRPPWEVHFIEGLEGGRFAIYIKMHHSLIDGYTGQKMLARSLS
TDPHDTTHPLFFNIPTPGRSPADTQDSVGGGLIAGAGNVLDGLGDVVRGLGGLVSGVG
SVLGSVAGAGRSTFELTKALVNAQLRSDHEYRNLVGSVQAPHCILNTRISRNRRFATQ
QYPLDRLKAIGAQYDATINDVALAIIGGGLRRFLDELGELPNKSLIVVLPVNVRPKDD
EGGGNAVATILATLGTDVADPVQRLAAVTASTRAAKAQLRSMDKDAILAYSAALMAPY
GVQLASTLSGVKPPWPYTFNLCVSNVPGPEDVLYLRGSRMEASYPVSLVAHSQALNVT
LQSYAGTLNFGFIGCRDTLPHLQRLAVYTGEALDQLAAADGAAGLGS"
gene complement(3900493..3901182)
/locus_tag="Rv3481c"
CDS complement(3900493..3901182)
/codon_start=1
/transl_table=11
/locus_tag="Rv3481c"
/product="Probable integral membrane protein"
/note="Rv3481c, (MTCY13E12.34c), len: 229 aa. Probable
integral membrane protein. No real similarity with
others."
/db_xref="EnsemblGenomes-Gn:Rv3481c"
/db_xref="EnsemblGenomes-Tr:CCP46303"
/db_xref="GOA:I6XHC3"
/db_xref="InterPro:IPR021315"
/db_xref="UniProtKB/TrEMBL:I6XHC3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46303.1"
/translation="MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQP
RPSSLAFLGGWLLGLAVVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLR
WLTRHRHTEMPGWMRAFASFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAA
GSWIYTAFFAMLAASTVAIPILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIG
LLLLYNGVHAM"
gene complement(3901324..3902106)
/locus_tag="Rv3482c"
CDS complement(3901324..3902106)
/codon_start=1
/transl_table=11
/locus_tag="Rv3482c"
/product="Probable conserved membrane protein"
/note="Rv3482c, (MTCY13E12.35c), len: 260 aa. Probable
conserved membrane protein. N-terminal region shares some
similarity with N-terminus of O88067|SCI35.32c putative
membrane protein from Streptomyces coelicolor (319
aa),FASTA scores: opt: 155, E(): 0.023, (54.55% identity
in 33 aa overlap); and with C-terminus of
O06254|Rv3437|MTCY77.09 hypothetical 17.9 KDA protein from
Mycobacterium tuberculosis strain H37Rv (alias
AAK47883|MT3542.1 from strain CDC1551) (158 aa), FASTA
scores: opt: 140, E(): 0.11, (58.8% identity in 34 aa
overlap). Some similarity to others e.g. Q9XAN5|SC4C6.05c
putative membrane protein from Streptomyces coelicolor
(347 aa), FASTA scores: opt: 131,E(): 0.75, (29.4%
identity in 221 aa overlap). First start taken."
/db_xref="EnsemblGenomes-Gn:Rv3482c"
/db_xref="EnsemblGenomes-Tr:CCP46304"
/db_xref="GOA:I6YG92"
/db_xref="InterPro:IPR018929"
/db_xref="UniProtKB/TrEMBL:I6YG92"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46304.1"
/translation="MEHDVATSPPAGWYTDPDGSAGQRYWDGDRWTRHRRPNPSAPRS
PLALRVDGLRSRWLGMPAGLRLTVPVAAVLTMVGVAVYAWIRPLPDDWSQLPKRLSCQ
LRPGPTPPATITVASVDVSHPRGAVLRLVVRFAEPLPPSPSGSFASGFAGYLLTYTIA
NNGKEFAELGPQQDTDELAIRKPGESRGTEPNMRPDRNTNARRTAPDTVEINLETKRL
GLDQAPVDPQLTFAAQFRTPSTVTVDFGSQFCQGERLAGQRR"
gene complement(3902150..3902812)
/locus_tag="Rv3483c"
CDS complement(3902150..3902812)
/codon_start=1
/transl_table=11
/locus_tag="Rv3483c"
/product="Possible exported protein"
/note="Rv3483c, (MTCY13E12.36c), len: 220 aa. Possible
exported protein, similar to Q9CC94|ML1099 putative
lipoprotein from Mycobacterium leprae (202 aa), FASTA
scores: opt: 276, E(): 1.4e-08, (33.1% identity in 148 aa
overlap). Also showing similarity with Mycobacterium
tuberculosis proteins
Q11065|LPRE_MYCTU|LPRE|Rv1252c|MT1291|MTCY50.30. putative
lipoprotein precursor (202 aa), FASTA scores: opt:
276,E(): 1.4e-08, (29.5% identity in 200 aa overlap);
O53445|Rv1097c|MTV017.50c hypothetical 29.9 KDA protein
(293 aa), FASTA scores: opt: 161, E(): 0.047, (25.4%
identity in 118 aa overlap);
P71882|LPPP_MYCTU|Rv2330c|MT2392|MTCY3G12.04 putative
lipoprotein precursor (175 aa), FASTA scores: opt:
146,E(): 0.21, (28.25% identity in 184 aa overlap); and
O06170|Rv2507|MTCY07A7.13 hypothetical 28.5 KDA protein
(273 aa), FASTA scores: opt: 148, E(): 0.23, (25.15%
identity in 191 aa overlap). Contains possible N-terminal
signal sequence"
/db_xref="EnsemblGenomes-Gn:Rv3483c"
/db_xref="EnsemblGenomes-Tr:CCP46305"
/db_xref="GOA:I6X7F2"
/db_xref="InterPro:IPR025971"
/db_xref="UniProtKB/TrEMBL:I6X7F2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46305.1"
/translation="MSDEIDPDWPAPAYQPSDDVDTTPPAPGGSWPTAWLVALVVLAC
VAAAVVAYAGMHRVRPGANQAAPATTSAPARPTSPASQVGPCGPDEATAVRAALAQLA
PDSKTGRPWNSTPEDSNYDPCADLSAVLVTVQDATNSSPDQALMFHRGTFVGTATPRA
YPFTNLIGPASTNDIVVLSYRTRQSCDGCQDGILTIVGFAWRGDHVQILDSLPELFDA
PP"
gene 3903078..3904616
/gene="cpsA"
/locus_tag="Rv3484"
CDS 3903078..3904616
/codon_start=1
/transl_table=11
/gene="cpsA"
/locus_tag="Rv3484"
/product="Possible conserved protein CpsA"
/note="Rv3484, (MTCY13E12.37), len: 512 aa. Possible
cpsA,hypothetical protein, equivalent to
Q50160|CPSA|ML2247 hypothetical protein CPSA from
Mycobacterium leprae (516 aa), FASTA scores: opt: 2557,
E(): 1.6e-143, (74.9% identity in 518 aa overlap); and
with good similarity to Q9CCK9|ML0750 hypothetical protein
from Mycobacterium leprae (489 aa), FASTA scores: opt:
855, E(): 4.6e-43,(34.45% identity in 502 aa overlap).
Also similar (or with similarity) to hypothetical proteins
from Mycobacterium tuberculosis: P96872|Rv3267|MTCY71.07
(498 aa), FASTA scores: opt: 928, E(): 2.3e-47, (37.35%
identity in 498 aa overlap); and O53834|Rv0822c|MTV043.14c
(684 aa), FASTA scores: opt: 425, E(): 1.5e-17, (26.15%
identity in 524 aa overlap). Shows also similarity with
various bacterial proteins e.g. Q9KZK0|SCE34.26 conserved
hypothetical protein from Streptomyces coelicolor (507
aa), FASTA scores: opt: 329, E(): 5.3e-12, (28.85%
identity in 478 aa overlap); Q9K4E6|2SC6G5.02 conserved
hypothetical protein,possible membrane protein, from
Streptomyces coelicolor (382 aa), FASTA scores: opt: 305,
E(): 1.1e-10, (29.8% identity in 386 aa overlap);
O69850|SC1C3.08c putative transcriptional regulator from
Streptomyces coelicolor (366 aa), FASTA scores: opt: 304,
E(): 1.2e-10, (29.6% identity in 395 aa overlap);
Q9KZK3|SCE34.23 putative transcriptional regulator from
Streptomyces coelicolor (396 aa), FASTA scores: opt: 296,
E(): 3.8e-10, (31.25% identity in 349 aa overlap);
AAK43602|CPSA CPSA protein from Streptococcus agalactiae
(485 aa), FASTA scores: opt: 250,E(): 2.4e-07, (30.25%
identity in 162 aa overlap); etc. Predicted to be an outer
membrane protein (See Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3484"
/db_xref="EnsemblGenomes-Tr:CCP46306"
/db_xref="GOA:O06347"
/db_xref="InterPro:IPR004474"
/db_xref="InterPro:IPR027381"
/db_xref="UniProtKB/TrEMBL:O06347"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46306.1"
/translation="MARSEGNRPRHRAVPQPSRIRKRLSRGVMTLVSVVALLMTGAGY
WVAHGALGGITISQALTPEDPRSSGNNMNILLIGLDSRKDQEGNDLPWSVLKQLHAGD
SDDGGYNTNTLILVHVGADGKVVAFSIPRDDWVPFTGVPGYNHIKIKEAYGLTKQYVA
EQLANQGVSDRKELETRGREAARAATLRAVRSLTGVPIDYFAEINLAGFYDLAQTLGG
VDVCLNHAVYDSYSGADFPAGRQRLNAAQALAFVRQRHGLDNGDLDRTHRQQAFLSSV
MRELQDSGTFTNLDRLDNLMAVARKDVVLSAGWDEDLFRRMGDLAGGNVEFRTLPVVR
YDNIDGQDVNIIDPTAIRAEVAAAFGSAPPTSQTAAAAKPNPSTVVDVVNAGSISGLA
SQVSGALLKRGYTAGQVRDRESGDPFTTAIEYGAGAETDAQNVADLLGIDAPNHPDPA
VAPGHIRVTVDTNFSLPAPDEATAAATSTETSTYPLYGGGTTTDPTPDQGAPIDGGGV
PCVN"
gene complement(3904622..3905566)
/locus_tag="Rv3485c"
CDS complement(3904622..3905566)
/codon_start=1
/transl_table=11
/locus_tag="Rv3485c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv3485c, (MTCY13E12.38c), len: 314 aa. Probable
short-chain dehydrogenase/reductase, similar, but longer
41 aa, to P71824|Rv0769|MTCY369.14 putative short-chain
type dehydrogenase/reductase CY369.14 from Mycobacterium
tuberculosis (248 aa), FASTA scores: opt: 462, E():
1.8e-19, (34.0% identity in 253 aa overlap). Also similar
to various dehydrogenases e.g.
P25529|HDHA_ECOLI|HSDH|B1619 NAD-dependent 7
alpha-hydroxysteroid dehydrogenase (SDR family) from
Escherichia coli strain K12 (alias BAB35750|ECS2327 or
AAG56608|HDHA for strain O157:H7) (255 aa), FASTA scores:
opt: 462, E(): 1.8e-19, (34.7% identity in 248 aa
overlap); Q9FD15|RUBG putative reductase (SDR family) from
Streptomyces collinus (249 aa), FASTA scores: opt: 446,
E(): 1.5e-18, (36.1% identity in 255 aa overlap);
BAB51974|MLL5540 putative dehydrogenase from Rhizobium
loti (Mesorhizobium loti) (253 aa), FASTA scores: opt:
442, E(): 2.5e-18, (36.25% identity in 251 aa overlap);
Q08632|SDR1_PICAB short-chain type dehydrogenase/reductase
(SDR family) from Picea abies (Norway spruce) (Picea
excelsa) (271 aa), FASTA scores: opt: 441, E():
3.1e-18,(32.3% identity in 260 aa overlap); Q9A326|CC3380
2-deoxy-D-gluconate 3-dehydrogenase from Caulobacter
crescentus (260 aa), FASTA scores: opt: 436, E():
5.7e-18,(32.8% identity in 253 aa overlap);
Q16698|DECR_HUMAN 2,4-dienoyl-CoA reductase, mitochondrial
precursor from Homo sapiens (Human) (335 aa), FASTA
scores: opt: 430, E(): 1.5e-17, (30.4% identity in 306 aa
overlap); etc. Contains short-chain alcohol dehydrogenase
family signature (PS00061). Belongs to the short-chain
dehydrogenases/reductases family (SDR)."
/db_xref="EnsemblGenomes-Gn:Rv3485c"
/db_xref="EnsemblGenomes-Tr:CCP46307"
/db_xref="GOA:O06348"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O06348"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46307.1"
/translation="MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQ
DRTYLVTGGGSGIGKGVAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKTGAIGYEPA
DITDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTM
YVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSW
VRVNSIRPGLIRTDLVVPVTESPELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASW
ITGQVINVDGGHMLRRGPDFSPMLEPVFGADGLRGVVG"
gene 3905772..3906221
/locus_tag="Rv3486"
CDS 3905772..3906221
/codon_start=1
/transl_table=11
/locus_tag="Rv3486"
/product="Conserved protein"
/note="Rv3486, (MTCY13E12.39), len: 149 aa. Conserved
protein, similar to Q9RC47|YFID|BH3304 hypothetical
protein from Bacillus halodurans (129 aa), FASTA scores:
opt: 186,E(): 2.1e-05, (40.0% identity in 95 aa overlap);
and Q9KKT1|VCA1019 hypothetical protein from Vibrio
cholerae (148 aa), FASTA scores: opt: 128, E(): 0.15,
(35.25% identity in 139 aa overlap). Some similarity to
other proteins e.g. P54720|YFID_BACSU hypothetical protein
from Bacillus subtilis (134 aa), FASTA scores: opt: 165,
E(): 0.00052, (31.75% identity in 126 aa overlap).
Equivalent to AAK47949 from Mycobacterium tuberculosis
strain CDC1551 (163 aa) but shorter 14 aa."
/db_xref="EnsemblGenomes-Gn:Rv3486"
/db_xref="EnsemblGenomes-Tr:CCP46308"
/db_xref="GOA:O06349"
/db_xref="InterPro:IPR032808"
/db_xref="UniProtKB/Swiss-Prot:O06349"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46308.1"
/translation="MHAEGPPSVICIRLLVGLVFLSEGIQKFMYPDQLGPGRFERIGI
PAATFFADLDGVVEIVCGTLVLLGLLTRVAAVPLLIDMVGAIVLTKLRALQPGGFLGV
EGFWGMAHAARTDLSMLLGLIFLLWSGPGRWSLDRRLSKRATACGAR"
gene complement(3906174..3907007)
/gene="lipF"
/locus_tag="Rv3487c"
CDS complement(3906174..3907007)
/codon_start=1
/transl_table=11
/gene="lipF"
/locus_tag="Rv3487c"
/product="Probable esterase/lipase LipF"
/note="Rv3487c, (MTCY13E12.41c), len: 277 aa. Probable
lipF, esterase/lipase (see citation below), highly
similar,but shorter 50 aa, to O53424|LIPU|Rv1076|MTV017.29
putative esterase/lipase from Mycobacterium tuberculosis
(297 aa),FASTA scores: opt: 1229, E(): 3.3e-71, (76.4%
identity in 246 aa overlap); and similar to other putative
lipases from Mycobacterium tuberculosis e.g.
P71759|LIPK|RV2385|MTCY253.36c (306 aa), FASTA scores:
opt: 468, E(): 1.2e-22, (36.2% identity in 254 aa
overlap). Equivalent, but shorter 79 aa, to
Q9ZBM4|MLCB1450.08|ML0314 putative hydrolase (putative
esterase) from Mycobacterium leprae (335 aa), FASTA
scores: opt: 1225, E(): 6.6e-71,(73.6% identity in 250 aa
overlap). Also similar to esterases and lipases of around
300 aa e.g. Q44087|est esterase precursor from
Acinetobacter lwoffii (303 aa),FASTA scores: opt: 428,
E(): 4.3e-20, (31.85% identity in 251 aa overlap);
P18773|EST_ACICA esterase from Acinetobacter calcoaceticus
(303 aa), FASTA scores: opt: 420, E(): 1.4e-19, (31.5%
identity in 251 aa overlap); Q9KIU1 esterase from
uncultured bacterium Plasmid pAH116 (308 aa), FASTA
scores: opt: 405, E(): 1.3e-18, (35.1% identity in 242 aa
overlap); Q9X8J4|SCE9.22 putative esterase from
Streptomyces coelicolor (266 aa), FASTA scores: opt: 390,
E(): 1e-17, (35.85% identity in 237 aa overlap); etc.
Equivalent to AAK47950 from Mycobacterium tuberculosis
strain CDC1551 (327 aa) but shorter 50 aa."
/db_xref="EnsemblGenomes-Gn:Rv3487c"
/db_xref="EnsemblGenomes-Tr:CCP46309"
/db_xref="GOA:O06350"
/db_xref="InterPro:IPR013094"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR033140"
/db_xref="UniProtKB/Swiss-Prot:O06350"
/protein_id="CCP46309.1"
/translation="MRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNALSGFAE
SPVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGDSAGGYLALALAQR
LQCDDEKPAAIVAISPLLQLAKGPKQDHPNIGTDAMFPARAFDALAAWVRAAAAKNMV
DGRPEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQA
HLFQLATPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSP
I"
gene 3907667..3907990
/locus_tag="Rv3488"
CDS 3907667..3907990
/codon_start=1
/transl_table=11
/locus_tag="Rv3488"
/product="Conserved hypothetical protein"
/note="Rv3488, (MTCY13E12.41), len: 107 aa. Hypothetical
protein, similar to various bacterial proteins e.g.
O28730|AF1542 conserved hypothetical protein from
Archaeoglobus fulgidus (101 aa), FASTA scores: opt:
321,E(): 6.4e-15, (50.55% identity in 87 aa overlap);
O50207 SQ1_IV (fragment) from Rhodococcus erythropolis (59
aa),FASTA scores: opt: 298, E(): 1.4e-13, (71.2% identity
in 59 aa overlap); Q9KFB0|BH0575 BH0575 protein from
Bacillus halodurans (102 aa), FASTA scores: opt: 294, E():
4.1e-13,(43.15% identity in 95 aa overlap); etc. Also
similar to Mycobacterium tuberculosis
P71704|Rv0047c|MTCY21D4.10c (180 aa) (37.8% identity in 82
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3488"
/db_xref="EnsemblGenomes-Tr:CCP46310"
/db_xref="GOA:I6X7F9"
/db_xref="InterPro:IPR005149"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:5ZHC"
/db_xref="PDB:5ZHV"
/db_xref="PDB:5ZI8"
/db_xref="UniProtKB/Swiss-Prot:I6X7F9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46310.1"
/translation="MREFQRAAVRLHILHHAADNEVHGAWLTQELSRHGYRVSPGTLY
PTLHRLEADGLLVSEQRVVDGRARRVYRATPAGRAALTEDRRALEELAREVLGGQSHT
AGNGT"
gene 3908072..3908236
/locus_tag="Rv3489"
CDS 3908072..3908236
/codon_start=1
/transl_table=11
/locus_tag="Rv3489"
/product="Unknown protein"
/note="Rv3489, (MTCY13E12.42), len: 54 aa. Unknown
protein. No similarity with other proteins."
/db_xref="EnsemblGenomes-Gn:Rv3489"
/db_xref="EnsemblGenomes-Tr:CCP46311"
/db_xref="UniProtKB/TrEMBL:I6YC91"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46311.1"
/translation="MSTKSDHGEIGDVEPLADSTASQARRVVAAYANDADECRIFLSM
LGIGPAKLES"
gene 3908236..3909738
/gene="otsA"
/locus_tag="Rv3490"
CDS 3908236..3909738
/codon_start=1
/transl_table=11
/gene="otsA"
/locus_tag="Rv3490"
/product="Alpha, alpha-trehalose-phosphate synthase
[UDP-forming] OtsA (trehalose-6-phosphate synthase)
(UDP-glucose-glucosephosphate glucosyltransferase)
(trehalosephosphate-UDP glucosyltransferase)
(trehalose-6-phosphate synthetase) (trehalose-phosphate
synthase) (trehalose-phosphate synthetase)
(transglucosylase) (trehalosephosphate-UDP glucosyl
transferase)"
/note="Rv3490, (MTCY13E12.43), len: 500 aa. otsA,
alpha,alpha-trehalose-phosphate synthase (see citations
below),equivalent to Q50167|OTSA|ML2254 probable
trehalose-phosphate synthase from Mycobacterium leprae
(498 aa), FASTA scores: opt: 2706, E(): 1.6e-166, (80.3%
identity in 497 aa overlap). Also similar to others e.g.
Q92410|TPS1_CANAL from Candida albicans (Yeast) (478
aa),FASTA scores: opt: 895, E(): 4.9e-50, (37.15% identity
in 479 aa overlap);
Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YBR
0922 from Saccharomyces cerevisiae (Baker's yeast) (495
aa),FASTA scores: opt: 847, E(): 6.2e-47, (36.1% identity
in 490 aa overlap); BAB48232|MLL0691 from Rhizobium loti
(Mesorhizobium loti) (520 aa), FASTA scores: opt: 884,
E(): 2.7e-49, (36.2% identity in 478 aa overlap); etc.
Equivalent to AAK47953 from Mycobacterium tuberculosis
strain CDC1551 (478 aa) but longer 22 aa."
/db_xref="EnsemblGenomes-Gn:Rv3490"
/db_xref="EnsemblGenomes-Tr:CCP46312"
/db_xref="GOA:P9WN11"
/db_xref="InterPro:IPR001830"
/db_xref="UniProtKB/Swiss-Prot:P9WN11"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46312.1"
/translation="MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWK
RSPGGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTT
DIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWV
QDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHL
PGGAQNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAA
RDRNIRRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVV
VQLATPSRERVESYQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVA
SDVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVK
DGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGAHPRGQG"
gene 3909890..3910468
/locus_tag="Rv3491"
CDS 3909890..3910468
/codon_start=1
/transl_table=11
/locus_tag="Rv3491"
/product="Unknown protein"
/note="Rv3491, (MTCY13E12.44), len: 192 aa. Unknown
protein. No significant homology with other proteins."
/db_xref="EnsemblGenomes-Gn:Rv3491"
/db_xref="EnsemblGenomes-Tr:CCP46313"
/db_xref="UniProtKB/TrEMBL:I6XHD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46313.1"
/translation="MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQ
AGVSGVTWTITALCDQPSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFS
GRARMSSMLWTFQVNQADGVACPDGSTAPSSETYAFSDETLTGTHTTVHGAVCGLQPK
LSKQPFSLQLIGPPPSPVQRYPLYCNNIAMCY"
gene complement(3910465..3910947)
/locus_tag="Rv3492c"
CDS complement(3910465..3910947)
/codon_start=1
/transl_table=11
/locus_tag="Rv3492c"
/product="Conserved hypothetical Mce associated protein"
/note="Rv3492c, (MTCY13E12.45c), len: 160 aa. Conserved
hypothetical Mce-associated protein, showing some
similarity to hypothetical Mycobacterium tuberculosis
proteins e.g. O53974|Rv1973|MTV051.11 (near Mce operon 3)
(160 aa), FASTA scores: opt: 214, E(): 2.6e-07, (25.3%
identity in 154 aa overlap); and
Q11032|YD62_MYCTU|Rv1362c|MT1407|MTCY02B10.26c (220
aa),FASTA scores: opt: 187, E(): 2e-05, (23.4% identity in
154 aa overlap). Contains lipocalin signature at
C-terminus (PS00213). Predicted to be an outer membrane
protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3492c"
/db_xref="EnsemblGenomes-Tr:CCP46314"
/db_xref="GOA:I6YGA5"
/db_xref="UniProtKB/TrEMBL:I6YGA5"
/inference="protein motif:PROSITE:PS00213"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46314.1"
/translation="MRRLISVAYALMVATIVGLSAAGGWFYWDRVQTGGEASARALLP
KLAMQEIPQVFGYDYQTVERSLTAVYPLLTPDYRQEFQKSANAQIIPEAKKREVVVQA
NVVGVGVMDAKRDCASVMVYLNRTVTDKTRQPLYDGSRLRVDFQRIDGKWLIAYITPI
"
gene complement(3910947..3911675)
/locus_tag="Rv3493c"
CDS complement(3910947..3911675)
/codon_start=1
/transl_table=11
/locus_tag="Rv3493c"
/product="Conserved hypothetical Mce associated alanine
and valine rich protein"
/note="Rv3493c, (MTCY13E12.46c), len: 242 aa. Conserved
hypothetical Mce-associated ala-, val-rich protein,
showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18
hypothetical 25.9 KDA protein (near Mce operon1) from
Mycobacterium tuberculosis (244 aa), FASTA scores: opt:
163, E(): 0.046, (24.65% identity in 211 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3493c"
/db_xref="EnsemblGenomes-Tr:CCP46315"
/db_xref="GOA:I6X7G4"
/db_xref="UniProtKB/TrEMBL:I6X7G4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46315.1"
/translation="MAADTGVAGGQQSTTRRARRKASRPAGPAEGESSRPAQGAATVR
AAARTESKPAKAAKPALRPVKPPPRRPAHRVLVGWLSLAAGLLAIAALAWGVTALVMQ
NRDADARQARNQRFVDAATQTVVNMFSYTPDTIDESVNRFVNGTSGPLRGMLNANNNV
DNLKGLFRATNATSEAVVNGAALEGIDEISDNASVLVSVRVTVADIDGVNKPSMPYRL
RVIVHEDENGRMTGYDLKYPDGGN"
gene complement(3911675..3913369)
/gene="mce4F"
/locus_tag="Rv3494c"
CDS complement(3911675..3913369)
/codon_start=1
/transl_table=11
/gene="mce4F"
/locus_tag="Rv3494c"
/product="Mce-family protein Mce4F"
/note="Rv3494c, (MTV023.01c), len: 564 aa. Mce4F; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), similar to Mycobacterium
tuberculosis proteins O07418|Rv0174|MTCI28.14|mce1F (515
aa); O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa); and
O53972|Rv1971|MTV051.09|mce3F (437 aa). Also similar to
others e.g. Q9CD09|MCE1F|ML2594 putative secreted protein
from Mycobacterium leprae (516 aa), FASTA scores: opt:
1040, E(): 3.6e-31, (35.9% identity in 529 aa overlap);
Q9F361|SC8A2.02c putative secreted protein from
Streptomyces coelicolor (433 aa), FASTA scores: opt:
570,E(): 3.7e-14, (30.8% identity in 458 aa overlap); etc.
Has hydrophobic stretch, possibly a signal peptide at the
N-terminus. Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3494c"
/db_xref="EnsemblGenomes-Tr:CCP46316"
/db_xref="GOA:I6YC95"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:I6YC95"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46316.1"
/translation="MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSA
DFVAGGGLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRSVS
AIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLLGSLGDTRLRE
LLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDI
KSLADGLARFTWQLRAADPRLRDTLADAPDAIDEANTAFSGIRPSFPALAASLANLGR
VGVIYHKSIEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPP
LVRSPADESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQLCRDPRGYV
PVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPPGQVAGPG
PAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEPPQVPYPATIPPPPPPEGTGPPPGP
APGPQPQASGPAYTIYDQLSGAFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL"
gene complement(3913380..3914534)
/gene="lprN"
/gene_synonym="mce4E"
/locus_tag="Rv3495c"
CDS complement(3913380..3914534)
/codon_start=1
/transl_table=11
/gene="lprN"
/gene_synonym="mce4E"
/locus_tag="Rv3495c"
/product="Possible Mce-family lipoprotein LprN (Mce-family
lipoprotein Mce4E)"
/note="Rv3495c, (MTV023.02c), len: 384 aa. Possible lprN
(alternate gene name: mce4E), lipoprotein which belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E
(390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa);
and O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also
similar to others e.g. Q9F360|SC8A2.03c putative secreted
protein from Streptomyces coelicolor (413 aa), FASTA
scores: opt: 656, E(): 2.2e-32, (37.55% identity in 317 aa
overlap); Q9CD10|LPRK|ML2593 putative lipoprotein from
Mycobacterium leprae (392 aa), FASTA scores: opt: 616,
E(): 5.5e-30, (28.95% identity in 373 aa overlap); etc.
Contains possible signal sequence and appropriately
positioned PS00013 Prokaryotic membrane lipoprotein lipid
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3495c"
/db_xref="EnsemblGenomes-Tr:CCP46317"
/db_xref="GOA:I6Y3P1"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/Swiss-Prot:I6Y3P1"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46317.1"
/translation="MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHGEGAYSV
TVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVKLDLDKNVLLPANAV
AKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITEANTDRFPTTEEVFSALGVVVNK
GNVGALEEIIDETHQAVAGRQAQFVNLVPRLAELTAGLNRQVHDIIDALDGLNRVSAI
LARDKDNLGRALDTLPDAVRVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDL
KDLYSIVKALNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGE
TFFTTAYFDPNMAHMDEILNPPDFLIGELANLSGQAADPFKIPPGTASGQ"
gene complement(3914531..3915886)
/gene="mce4D"
/locus_tag="Rv3496c"
CDS complement(3914531..3915886)
/codon_start=1
/transl_table=11
/gene="mce4D"
/locus_tag="Rv3496c"
/product="Mce-family protein Mce4D"
/note="Rv3496c, (MTV023.03c), len: 451 aa. Mce4D; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07416|Rv0172|MTCI28.12|mce1D (530 aa);
O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and
O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to
others e.g. Q9CD11|MCE1D|ML2592 putative secreted protein
from Mycobacterium leprae (531 aa), FASTA scores: opt:
837,E(): 2.6e-34, (34.55% identity in 446 aa overlap);
Q9F359|SC8A2.04c putative secreted protein from
Streptomyces coelicolor (337 aa), FASTA scores: opt:
606,E(): 4.9e-23, (32.35% identity in 300 aa overlap);
etc. Hydrophobic region at N-terminus. Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3496c"
/db_xref="EnsemblGenomes-Tr:CCP46318"
/db_xref="GOA:I6XHD6"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="InterPro:IPR024516"
/db_xref="UniProtKB/TrEMBL:I6XHD6"
/protein_id="CCP46318.1"
/translation="MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNKRTIVG
YFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVDVQAVIMSPN
LVAARFIQLTPVYTGGAVLPDNGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQ
GPLGAAINQAADTLDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSE
SDEQIVQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQL
NDFAQTLSDQSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGG
SFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKGQIIYDTP
ATEAKSETPVPELTWVPAGGGAPVGNPADLQSLLVPPAPGPAPAPPAPGAGPGEHGGG
G"
gene complement(3915883..3916956)
/gene="mce4C"
/locus_tag="Rv3497c"
CDS complement(3915883..3916956)
/codon_start=1
/transl_table=11
/gene="mce4C"
/locus_tag="Rv3497c"
/product="Mce-family protein Mce4C"
/note="Rv3497c, (MTV023.04c), len: 357 aa. Mce4C; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07415|R0171|MTCI28.11|mce1C (515 aa);
O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); and
O53969|Rv1968|MTV051.06|mce3C (410 aa). Also similar to
others e.g. Q9F358|SC8A2.05c putative secreted protein
from Streptomyces coelicolor (351 aa), FASTA scores: opt:
658,E(): 1.1e-30, (33.95% identity in 318 aa overlap);
Q9CD12|MCE1C|ML2591 putative secreted protein from
Mycobacterium leprae (519 aa), FASTA scores: opt: 555,
E(): 1.2e-24, (28.35% identity in 328 aa overlap); etc.
Hydrophobic region at N-terminus. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3497c"
/db_xref="EnsemblGenomes-Tr:CCP46319"
/db_xref="GOA:I6YGB1"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:I6YGB1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46319.1"
/translation="MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQG
KTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSLAA
IRTDTILGERSIAVSPAGSGKSTTIPLSRTTTPYTLNGVLQDLGRNANDLNRPQFEQA
LNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQGLLAHAKSVTSVLSERAEQVN
KLVEDGNQLFAALDARRAALSALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLAN
LNERRDYITEALKRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPGKL
PDSLADYLRGFIQERWIIRPKSP"
gene complement(3916946..3917998)
/gene="mce4B"
/locus_tag="Rv3498c"
CDS complement(3916946..3917998)
/codon_start=1
/transl_table=11
/gene="mce4B"
/locus_tag="Rv3498c"
/product="Mce-family protein Mce4B"
/note="Rv3498c, (MTV023.05c), len: 350 aa. Mce4B; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
O07414|Rv0170|MTCI28.10|mce1B (346 aa);
O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); and
O53968|Rv1967|MTV051.05|mce3B (342 aa). Also similar to
others e.g. Q9CD13|MCE1B|ML2590 putative secreted protein
from Mycobacterium leprae (346 aa), FASTA scores: opt:
803,E(): 6.1e-41, (41.05% identity in 346 aa overlap);
Q9F357|SC8A2.06c putative secreted protein from
Streptomyces coelicolor (354 aa), FASTA scores: opt:
624,E(): 3.4e-30, (32.55% identity in 338 aa overlap);
etc. Hydrophobic region at N-terminus. Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3498c"
/db_xref="EnsemblGenomes-Tr:CCP46320"
/db_xref="GOA:I6X7G8"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/TrEMBL:I6X7G8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46320.1"
/translation="MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTV
YHATFTDASRLKAGQKVRIAGVPVGSVKAVKLNPDHSIDVAFAIDRSYTLYSSTRAVI
RYENLVGDRFLEITSGPGELRKLPPGGTINVAHTQPALDLDALLGGLRPVLKGFDADK
INTITSAVIELLQGQGGPLANVLADTGAFSAALGARDQLIGEVITNLNAVLATVDAKS
AQFSASVDQLQQLVSGLAKNRDPIAGAISPLASTTTDLTELLRNSRRPLQGILENARP
LATELDNRKAEVNNDIEQLGEDYLRLSALGSYGAFFNIYFCSVTIKINGPAGSDILLP
IGGQPDPSKGRCAFAK"
gene complement(3917998..3919200)
/gene="mce4A"
/gene_synonym="mce4"
/locus_tag="Rv3499c"
CDS complement(3917998..3919200)
/codon_start=1
/transl_table=11
/gene="mce4A"
/gene_synonym="mce4"
/locus_tag="Rv3499c"
/product="Mce-family protein Mce4A"
/note="Rv3499c, (MTV023.06c), len: 400 aa. Mce4A; belongs
to 24-membered Mycobacterium tuberculosis Mce protein
family (see citations below), highly similar to
Mycobacterium tuberculosis proteins
P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa);
O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and
O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar
to others e.g. Q9F356|SC8A2.07c putative secreted protein
from Streptomyces coelicolor (418 aa), FASTA scores: opt:
619, E(): 7.8e-30, (32.4% identity in 352 aa overlap);
Q9S4U5|MCE1 mycobacterial cell entry protein from
Mycobacterium bovis BCG (454 aa), FASTA scores: opt:
529,E(): 2.1e-24, (30.35% identity in 448 aa overlap);
Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441
aa),FASTA scores: opt: 515, E(): 1.4e-23, (28.35% identity
in 430 aa overlap); etc. Contains a possible N-terminal
signal sequence. Note that previously known as mce4.
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3499c"
/db_xref="EnsemblGenomes-Tr:CCP46321"
/db_xref="GOA:I6YC99"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="InterPro:IPR024516"
/db_xref="UniProtKB/TrEMBL:I6YC99"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46321.1"
/translation="MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVT
VSSPRAGLVMEKGAKVKYRGIQVGKVTDISYSGNQARLKLAIDSGEMGFIPSNATVRI
AGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLET
NATLSALSEGLRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAG
DLNTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAINRLRAP
LKVTSDYSPVFGCLFKGIARGVKEFAPLIGVRKAGLFTSSSFVLGAPSYTYPESLPIV
NASGGPNCRGLPDIPTKQTGGSFYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNG
AFAERDDF"
gene complement(3919220..3920062)
/gene="yrbE4B"
/gene_synonym="supB"
/locus_tag="Rv3500c"
CDS complement(3919220..3920062)
/codon_start=1
/transl_table=11
/gene="yrbE4B"
/gene_synonym="supB"
/locus_tag="Rv3500c"
/product="Conserved integral membrane protein YrbE4B.
Possible ABC transporter."
/note="Rv3500c, (MTV023.07c), len: 280 aa.
YrbE4B,conserved integral membrane protein, part of mce4
operon and member of YrbE family (see citations below),
highly similar to Mycobacterium tuberculosis proteins
O07413|Rv0168|MTCI28.08|yrbE1B (289 aa);
O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); and
O53966|Rv1965|MTV051.03|yrbE3B (271 aa). Also highly
similar to conserved hypothetical integral membrane
proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g.
Q9CD15|YRBE1B|ML2588 from Mycobacterium leprae (289
aa),FASTA scores: opt: 973, E(): 1.5e-50, (50.2% identity
in 269 aa overlap); P45030|YRBE_HAEIN|HI1086 from
Haemophilus influenzae (261 aa), FASTA scores: opt: 270,
E(): 6e-11,(25.4% identity in 264 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3500c"
/db_xref="EnsemblGenomes-Tr:CCP46322"
/db_xref="GOA:I6Y3P5"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:I6Y3P5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46322.1"
/translation="MSYDVTIRFRRFFSRLQRPVDNFGEQALFYGETMRYVPNAITRY
RKETVRLVAEMTLGAGALVMIGGTVGVAAFLTLASGGVIAVQGYSSLGDIGIEALTGF
LSAFLNVRVVAPVIAGIALAATIGAGATAQLGAMRVSEEIDAVECMAVHSVSYLVSTR
LIAGLVAIIPLYSLSVLAAFFAARFTTVFVNGQSAGLYDHYFNTFLIPSDLLWSFMQA
IAMSIAVMLVHTYYGYNASGGSVGVGVAVGQAVRTSLIVVVVITLFISLAVYGASGNF
NLSG"
gene complement(3920097..3920861)
/gene="yrbE4A"
/gene_synonym="supA"
/locus_tag="Rv3501c"
CDS complement(3920097..3920861)
/codon_start=1
/transl_table=11
/gene="yrbE4A"
/gene_synonym="supA"
/locus_tag="Rv3501c"
/product="Conserved integral membrane protein YrbE4A.
Possible ABC transporter."
/note="Rv3501c, (MTV023.08c), len: 254 aa.
YrbE4A,conserved integral membrane protein, part of mce4
operon and member of YrbE family (see citations below),
highly similar to Mycobacterium tuberculosis proteins
O07412|Rv0167|MTCI28.07|yrbE1A (265 aa);
O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); and
O53965|Rv1964|MTV051.02|yrbE3A (265 aa). Also highly
similar to conserved hypothetical integral membrane
proteins of the P45030|YRBE_HAEIN (261 aa) type, e.g.
Q9CD16|YRBE1A|ML2587 from Mycobacterium leprae (267
aa),FASTA scores: opt: 1059, E(): 1e-57, (64.75% identity
in 247 aa overlap); P45030|YRBE_HAEIN|HI1086 from
Haemophilus influenzae (261 aa), FASTA scores: opt: 313,
E(): 3e-14,(25.7% identity in 241 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3501c"
/db_xref="EnsemblGenomes-Tr:CCP46323"
/db_xref="GOA:O53546"
/db_xref="InterPro:IPR030802"
/db_xref="UniProtKB/TrEMBL:O53546"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46323.1"
/translation="MIQQLAVPARAVGGFFEMSMDTARAAFRRPFQFREFLDQTWMVA
RVSLVPTLLVSIPFTVLVAFTLNILLREIGAADLSGAGTAFGTITQLGPVVTVLVVAG
AGATAICADLGARTIREEIDAMRVLGIDPIQRLVVPRVLASTLVALLLNGLVCAIGLS
GGYAFSVFLQGVNPGAFINGLTVLTGLRELILAEIKALLFGVMAGLVGCYRGLTVKGG
PKGVGNAVNETVVYAFICLFVINVVMTAIGVRISAQ"
gene complement(3921087..3922040)
/gene_synonym="hsd4A"
/locus_tag="Rv3502c"
CDS complement(3921087..3922040)
/codon_start=1
/transl_table=11
/gene_synonym="hsd4A"
/locus_tag="Rv3502c"
/product="Probable short-chain type
dehydrogenase/reductase. Possible 17-beta-hydroxysteroid
dehydrogenase."
/note="Rv3502c, (MTV023.09c), len: 317 aa (start
uncertain). Probable short-chain dehydrogenase/reductase
,similar to Mycobacterium tuberculosis proteins
P71853|Rv3548c|MTCY03C7.08 hypothetical 31.1 KDA protein
(304 aa), FASTA scores: opt: 739, E(): 6.2e-35, (45.15%
identity in 310 aa overlap); and
Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14
putative oxidoreductase (247 aa), FASTA scores: opt: 475,
E(): 5.1e-20, (40.15% identity in 254 aa overlap). Also
similar to various dehydrogenases e.g. Q9I4V1|PA1023
probable short-chain dehydrogenase from Pseudomonas
aeruginosa (305 aa), FASTA scores: opt: 535, E(): 2.3e-23,
(37.1% identity in 302 aa overlap); Q9UVH9|FOX2 FOX2
protein (SDR family) (1015 aa), FASTA scores: opt: 487,
E(): 3.2e-20, (38.4% identity in 276 aa overlap);
P22414|FOX2_CANTR peroxisomal hydratase-dehydrogenase,
D-3-hydroxyacyl CoA dehydrogenase (SDR family) from
Candida tropicalis (Yeast) (906 aa) FASTA scores: opt:
481, E(): 6.4e-20, (38.0% identity in 250 aa overlap);
P50171|DHB8_MOUSE|HSD17B8|HKE6|H2-KE6 estradiol 17
beta-dehydrogenase 8 from Mus musculus (Mouse) (260 aa)
FASTA scores: opt: 459, E(): 4.3e-19, (39.75% identity in
259 aa overlap); CAC41362|BKR1 3-oxyacyl-[acyl-carrier
protein] reductase (fragment) from Brassica napus (Rape)
(317 aa), FASTA scores: opt: 447, E(): 2.4e-18, (39.2%
identity in 255 aa overlap); etc. Contains PS00061
Short-chain dehydrogenases/reductases family signature.
Belongs to the short-chain dehydrogenases/reductases (SDR)
family."
/db_xref="EnsemblGenomes-Gn:Rv3502c"
/db_xref="EnsemblGenomes-Tr:CCP46324"
/db_xref="GOA:O53547"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O53547"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46324.1"
/translation="MKLTESNRSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLG
ATVVVNDVASALDASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGGL
DIVVNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAEGGSVF
GRLVNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGRYGVCANVICPRARTAMT
ADVFGAAPDVEAGQIDPLSPQHVVSLVQFLASPAAAEVNGQVFIVYGPQVTLVSPPHM
ERRFSADGTSWDPTELTATLRDYFAGRDPEQSFSATDLMRQ"
gene complement(3922065..3922256)
/gene="fdxD"
/locus_tag="Rv3503c"
CDS complement(3922065..3922256)
/codon_start=1
/transl_table=11
/gene="fdxD"
/locus_tag="Rv3503c"
/product="Probable ferredoxin FdxD"
/note="Rv3503c, (MTV023.10c), len: 63 aa. Probable
fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226
hypothetical 9.3 KDA protein from Mycobacterium leprae (83
aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity
in 54 aa overlap). Also similar to several e.g.
Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa),
FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in
60 aa overlap); Q9X4X8|DITA3 dioxygenase DITA ferredoxin
component from Pseudomonas abietaniphila (78 aa), FASTA
scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa
overlap); P00203|FER_MOOTH from Moorella thermoacetica
(Clostridium thermoaceticum) (63 aa), FASTA scores: opt:
157, E(): 5.4e-05, (36.65% identity in 60 aa overlap);
P18325|FER2_STRGO|SUBB from Streptomyces griseolus (64 aa)
FASTA scores: opt: 157, E(): 5.5e-05, (39.35% identity in
61 aa overlap); etc. Belongs to the bacterial type
ferredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv3503c"
/db_xref="EnsemblGenomes-Tr:CCP46325"
/db_xref="GOA:I6X7H4"
/db_xref="InterPro:IPR001080"
/db_xref="UniProtKB/TrEMBL:I6X7H4"
/protein_id="CCP46325.1"
/translation="MRVIVDRDRCEGNAVCLGIAPDIFDLDDEDYAVVKTDPIPVDQE
DLAEQAIAECPRAALSRGE"
gene 3922471..3923673
/gene="fadE26"
/locus_tag="Rv3504"
CDS 3922471..3923673
/codon_start=1
/transl_table=11
/gene="fadE26"
/locus_tag="Rv3504"
/product="Probable acyl-CoA dehydrogenase FadE26"
/note="Rv3504, (MTV023.11), len: 400 aa. Probable
fadE26,acyl-CoA dehydrogenase, similar to other acyl-CoA
dehydrogenases from Mycobacterium tuberculosis e.g.
P71858|FADE29|Rv3543c|MTCY03C7.13 (387 aa) FASTA scores:
opt: 1031, E(): 7.5e-59, (46.25% identity in 402 aa
overlap); and P95280|FADE17|Rv1934c|MTCY09F9.30 (409
aa),FASTA scores: opt: 617, E(): 3.1e-32, (32.6% identity
in 423 aa overlap); etc. Also similar to others e.g.
Q9A6G3|CC2131 from Caulobacter crescentus (403 aa) FASTA
scores: opt: 710, E(): 3.2e-38, (33.4% identity in 413 aa
overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381
aa), FASTA scores: opt: 522, E(): 3.7e-26, (34.1% identity
in 358 aa overlap); Q9RJX2|SCF37.29c from Streptomyces
coelicolor (393 aa), FASTA scores: opt: 509, E():
2.6e-25,(34.45% identity in 363 aa overlap); etc. Could
belong to the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3504"
/db_xref="EnsemblGenomes-Tr:CCP46326"
/db_xref="GOA:I6YCA3"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="PDB:4X28"
/db_xref="UniProtKB/Swiss-Prot:I6YCA3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46326.1"
/translation="MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNV
YRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTI
MAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMW
TSLIQYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATY
YSDVRVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGG
TRLIDSEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELA
TEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVA
LGLPRANR"
gene 3923698..3924819
/gene="fadE27"
/locus_tag="Rv3505"
CDS 3923698..3924819
/codon_start=1
/transl_table=11
/gene="fadE27"
/locus_tag="Rv3505"
/product="Probable acyl-CoA dehydrogenase FadE27"
/note="Rv3505, (MTV023.12), len: 373 aa. Probable
fadE27,acyl-CoA dehydrogenase, similar to other acyl-CoA
dehydrogenases from Mycobacterium tuberculosis e.g.
P71857|FADE28|Rv3544c|MTCY03C7.12 (339 aa) FASTA scores:
opt: 497, E(): 1.8e-22, (30.3% identity in 343 aa
overlap); and P95281|FADE18|Rv1933c|MTCY09F9.31 (363 aa)
FASTA scores: opt: 421, E(): 6.4e-18, (32.35% identity in
334 aa overlap). Also similar to other e.g. Q9A5G8|CC2479
from Caulobacter crescentus (344 aa), FASTA scores: opt:
425,E(): 3.5e-18, (30.75% identity in 351 aa overlap);
Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa)
FASTA scores: opt: 317, E(): 1e-11, (32.8% identity in 372
aa overlap); Q9L8Q3|PDTORFO from Pseudomonas stutzeri
(Pseudomonas perfectomarina) (513 aa), FASTA scores: opt:
301, E(): 1.2e-10, (25.9% identity in 394 aa overlap);
etc. Could belong to the acyl-CoA dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3505"
/db_xref="EnsemblGenomes-Tr:CCP46327"
/db_xref="GOA:I6Y3Q0"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="PDB:4X28"
/db_xref="UniProtKB/Swiss-Prot:I6Y3Q0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46327.1"
/translation="MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELW
RKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLAAGALARFG
SPELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGTGHGYRLTGTRTQVGYGPVADA
FLVPAETDSGAAVFLVAAGDPGVAVTALATTGLGSVGHLELNGAKVDAARRVGGTDVA
VWLGTLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVK
GLRLTLTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGV
DTDHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA"
gene 3924890..3926398
/gene="fadD17"
/locus_tag="Rv3506"
CDS 3924890..3926398
/codon_start=1
/transl_table=11
/gene="fadD17"
/locus_tag="Rv3506"
/product="Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA
synthase) (fatty-acid-CoA ligase)"
/note="Rv3506, (MTV023.13), len: 502 aa.
fadD17,fatty-acid-CoA synthetase (ligase), similar to
P72007|FADD1|RV1750c|MTCY28.13c|MTCY04C12.34 from
Mycobacterium tuberculosis (532 aa), FASTA scores: opt:
666, E(): 9.8e-32, (52.05% identity in 488 aa overlap).
Also similar to various ligases/synthetases e.g.
Q9EY88|FCS feruloyl-CoA synthetase from Amycolatopsis sp.
HR167 (491 aa), FASTA scores: opt: 490, E(): 2.1e-21,
(30.3% identity in 462 aa overlap); BAB33463|ECS0040
(alias AAG54340|CAIC) probable
crotonobetaine/carnitine-CoA ligase from Escherichia coli
strain O157:H7 (522 aa), FASTA scores: opt: 478, E():
1.1e-20, (28.5% identity in 347 aa overlap); Q9KHL1|ENCH
putative acyl-CoA ligase from Streptomyces maritimus (535
aa), FASTA scores: opt: 477, E(): 1.3e-20,(28.7% identity
in 453 aa overlap); Q50017|XCLC|ML1051 acyl-CoA synthase
from Mycobacterium leprae (476 aa), FASTA scores: opt:
472, E(): 2.3e-20, (31.35% identity in 469 aa overlap);
P31552|CAIC_ECOLI|B0037 from Escherichia coli strain K12
(522 aa), FASTA scores: opt: 467, E(): 4.8e-20,(28.75%
identity in 348 aa overlap); Q9KBC2|BH2006 from Bacillus
halodurans long-chain acyl-CoA synthetase (ligase) (513
aa), FASTA scores: opt: 462, E(): 9.4e-20, (27.65%
identity in 463 aa overlap); etc. Contains PS00455
Putative AMP-binding domain signature."
/db_xref="EnsemblGenomes-Gn:Rv3506"
/db_xref="EnsemblGenomes-Tr:CCP46328"
/db_xref="GOA:O53551"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR030310"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:O53551"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46328.1"
/translation="MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAA
ALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKAD
CQLVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGT
SGDPKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGS
MALRRKFSASQFLADVRRYGATYANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVP
GDIDRFGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPLPGGIQIVDPDTGEPCPT
GVVGELVNTAGPGGFEGYYNDEAAEAERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWM
RVDGENLGTAPIERVLMRYPDATEVAVYPVPDPVVGDQVMAALVLAPGTKFDADKFRA
FLTEQPDLGHKQWPSYVRVSAGLPRTMTFKVIKRQLSAEGVACADPVWPIRR"
gene 3926569..3930714
/gene="PE_PGRS53"
/locus_tag="Rv3507"
CDS 3926569..3930714
/codon_start=1
/transl_table=11
/gene="PE_PGRS53"
/locus_tag="Rv3507"
/product="PE-PGRS family protein PE_PGRS53"
/note="Rv3507, (MTV023.14), len: 1381 aa. PE_PGRS53,
Member of the Mycobacterium tuberculosis PE protein
family, PGRS subfamily of gly-rich proteins (see citation
below),similar to others from Mycobacterium tuberculosis
strains H37Rv and CDC1551 e.g. O06810|Rv1450c|MTCY493.04
(1329 aa),FASTA scores: opt: 2173, E(): 1.4e-135, (51.15%
identity in 1412 aa overlap). Equivalent to AAK47970 from
Mycobacterium tuberculosis strain CDC1551 (1384 aa) but
with some minor differences between the proteins. Contains
two PS00583 pfkB family of carbohydrate kinases signatures
1."
/db_xref="EnsemblGenomes-Gn:Rv3507"
/db_xref="EnsemblGenomes-Tr:CCP46329"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MWW9"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46329.1"
/translation="MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVVSAAA
DEVSTAVAALFSQHAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFAEAANASPLQSAM
GAVSASAQTLLSRPLIGNGANATTPGGNGGDGGWLFGSGGNGAPGAAGQSGGNGGSAG
LWGNGGAGGAGGSGGAAGGNGGNGGWLFGAGGTGGIGGTGAPGAMGGTGGNGGNGALL
IGGGGLGGAGGMGGTGGGTGGTGGNGGNGALLIGAGGVGGAGGIGGQGTGAGGAAGAG
GTGGNGGAGGLFMNGGDGGAGGQGGDGAAGDAAASAGGTGGKGGQGGDGGTGGAGGAG
PVLFGHGGAGGMGGQGGTGGMGGAGGDGTTVIAAGTGGEGGTGGAAGAGGAAGARGAL
TSGGLAGGVGAGGTGGTGGTGGNGADAAAVVGFGANGDPGFAGGKGGNGGIGGAAVTG
GVAGDGGTGGKGGTGGAGGAGNDAGSTGNPGGKGGDGGIGGAGGAGGAAGTGNGGHAG
NTGDGGDGGTGGNGGNGTGGVNGADNTLNPDTPGGAGEPGGAGGAGGAGGAAGGPGGT
GGTGGNGGNGGNGGNGGNGGNGGNGGNAGNNSTNAPVGGEGGAGGDGGAGGAGGAANG
GTAGSQGTGGVGGDGGAGGNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVGGAAGA
NGGTGGSGGNGGDGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAG
GAGGQGGNAGQGGAGGAGGNAVIPGDGVGKAPHGDAGGSGGDGGKGGQGGSGGTGGSG
APIGGGAGGTGGSGGHAGKGGAGGIGAQGTTITVPGNGGNAGDGGNGGNAGAGGNGGS
GDFGGNTTSGASGSGGNGGNAGTAGSGGAGGTGGTGLSGGNGGNGGNGGNGGDGGNGA
HGTVGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAGAPGPTTGGNAGSQGIGGDGG
NGGDGGKGGDGADAVNVVFMPTEPQAATGTAGSAGDPTGGNGGPGTPGSPMVAPPPPT
PITQVQQGGDGGAGGTGSTNANDGTATGGKGGEGGVGSILGGPGGNGGTGGNASATGT
NGVANAGNGGKGGDGGQFGAGGNGGAGGSVTDGSAGSTAGNGGNGGNATNGTIAGQPA
GGNGSAGGKGGDGGNIAAGATGTAGNGGNGGNGNDGAVNAGTGGSGGNGGNAGGGGAN
GGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNGGNGGTGGVGSVGAAG
GDGGNGGTGGFAGFGGTAGNGGSGGTGGAGGDGGTGGDGGNGVIAGGGGTGGNGGASG
AGGAGGTGGFAGNGNAGGNGGTGGASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLG
GVA"
gene 3931005..3936710
/gene="PE_PGRS54"
/locus_tag="Rv3508"
CDS 3931005..3936710
/codon_start=1
/transl_table=11
/gene="PE_PGRS54"
/locus_tag="Rv3508"
/product="PE-PGRS family protein PE_PGRS54"
/note="Rv3508, (MTV023.15), len: 1901 aa. PE_PGRS54,
Member of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan & Delogu
2002), similar to others from Mycobacterium tuberculosis
strains H37Rv and CDC1551 e.g. downstream
O53559|Rv3514|MTV023.21 (1489 aa),FASTA scores: opt: 6598,
E(): 0, (71.05% identity in 1533 aa overlap). Equivalent
to AAK47971 from Mycobacterium tuberculosis strain CDC1551
(1384 aa) but shorter 13 aa and with some minor
differences between the proteins. Contains five PS00583
pfkB family of carbohydrate kinases signatures 1."
/db_xref="EnsemblGenomes-Gn:Rv3508"
/db_xref="EnsemblGenomes-Tr:CCP46330"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:O53553"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46330.1"
/translation="MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGA
DEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAAAAEQIVLGV
INAPTQALLGRPLIGDGANATTPGGAGGAGGLLFGNGGAGAAGAPGQAGGPGGPAGLW
GNGGPGGAGGSGGGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAG
GVGGAGGGTGGAGGRAELLFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGA
GGAGGQGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGG
TGGAGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSAGGAAGAVGVGGTGGQGG
AGGAGAAGADAPASTGLTGGTGFAGGAGGVGGQGGNAIAGGINGSGGAGGTGGQGGAG
GMGGSGADNASGIGADGGAGGTGGNAGAGGAGGAAGTGGTGGVVGAAGKAGIGGTGGQ
GGAGGAGSAGTDATATGATGGTGFSGGAGGAGGAGGNTGVGGTNGSGGQGGTGGAGGA
GGAGGVGADNPTGIGGTGGTGGKGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQGGAGG
AGGAGADNPTGIGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNAGIGGTGGTG
GVGGAGGAGAAAAAGSSATGGAGFAGGAGGEGGAGGNSGVGGTNGSGGAGGAGGKGGT
GGAGGSGADNPTGAGFAGGAGGTGGAAGAGGAGGATGTGGTGGVVGATGSAGIGGAGG
RGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAGGAGGNGGDGGDGATGA
AGLGDNGGVGGDGGAGGAAGNGGNAGVGLTAKAGDGGAAGNGGNGGAGGAGGAGDNNF
NGGQGGAGGQGGQGGLGGASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGG
DGGDAGSGGGGGFGGAAGKAGGGGNGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGG
SAGAGGINGAGGAGGNGGDGGDGATGAAGLGDNGGVGGDGGAGGAAGNGGNAGVGLTA
KAGDGGAAGNGGNGGAGGAGGAGDNNFNGGQGGAGGQGGQGGLGGASTTSINANGGAG
GNGGTGGKGGAGGAGTLGVGGSGGTGGDGGDAGSGGGGGFGGAAGKAGGGGNGGVGGD
GGEGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAGGAGGTGGAGGDGAPATLIGG
PDGGDGGQGGIGGDGGNAGFGAGVPGDGGDGGNAGFGAGVPGDGGIGGTGGAGGAGGA
GADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGDGDGF
IGGSGGTGGTGGDAGVGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQDGNGFAG
GQGGQGGVGGNAGAGGINGAGGTGGTGGAGGDGQNGTTGVASEGGAGGQGGDGGQGGI
GGAGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPSIDGGQGGAGGHGGQGGKGGL
NSTGLASAASGDGGNGGAGGAGGNGGDGDGFIGGSGGTGGTGGDAGVGGLANTGGTAG
NAGIGGAGGRGGDGGAGDSGALSQDGNGFAGGQGGQGGVGGNAGAGGINGAGGTGGTG
GAGGDGQNGTTGVASEGGAGGQGGDGGQGGIGGAGGNAGFGAGVPGDGGIGGTGGAGG
AGGAGADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGA
GGLGGGGGTGGTNGNGGLGGGGGNGGAGGAGGTPTGSGTEGTGGDGGDAGAGGNGGSA
TGVGNGGNGGDGGNGGDGGNGAPGGFGGGAGAGGLGGSGAGGGTDGDDGNGGSPGTDG
S"
gene complement(3936877..3938424)
/gene="ilvX"
/locus_tag="Rv3509c"
CDS complement(3936877..3938424)
/codon_start=1
/transl_table=11
/gene="ilvX"
/locus_tag="Rv3509c"
/product="Probable acetohydroxyacid synthase IlvX
(acetolactate synthase)"
/note="Rv3509c, (MTV023.16), len: 515 aa. Probable
ilvX,acetohydroxyacid synthase, equivalent to
Mycobacterium leprae protein described as Acetolactate
synthase I, valine sensitive, large subunit
Q49865|ILVX|ILVI1|B229_C3_222 (515 aa), FASTA scores: opt:
2762, E(): 8.8e-145, (82.9% identity in 515 aa overlap).
Also similar to various enzymes (principally
acetohydroxyacid/acetolactate synthases) e.g.
Q9AB41|CC0393 thiamine-pyrophosphate-requiring enzyme from
Caulobacter crescentus (512 aa), FASTA scores: opt: 1572,
E(): 2.8e-79,(50.95% identity in 514 aa overlap);
BAB50432|MLL3567 acetolactate synthase I from Rhizobium
loti (Mesorhizobium loti) (517 aa), FASTA scores: opt:
1440, E(): 5.2e-72,(47.9% identity in 548 aa overlap);
P20906|MDLC_PSEPU benzoylformate decarboxylase from
Pseudomonas putida (528 aa), FASTA scores: opt: 356, E():
2.5e-12, (28.1% identity in 530 aa overlap);
Q9L123|SC6D11.33c putative decarboxylase from Streptomyces
coelicolor (526 aa), FASTA scores: opt: 325, E(): 1.3e-10,
(33.2% identity in 530 aa overlap); Q9RDF9|SCC57A.40c
putative acetolactate synthase from Streptomyces
coelicolor (564 aa), FASTA scores: opt: 304, E(): 1.9e-09,
(28.55% identity in 550 aa overlap); P94783
valine-sensitive acetohydroxy acid synthase from
Citrobacter freundii (561 aa), FASTA scores: opt: 278,
E(): 5.1e-08, (25.8% identity in 550 aa overlap);
Q42767|AHAS acetohydroxyacid synthase from Gossypium
hirsutum (Upland cotton) (659 aa), FASTA scores: opt: 278,
E(): 5.8e-08,(26.15% identity in 558 aa overlap); etc.
Note that other Mycobacterium tuberculosis proteins, e.g.
O53250|MTV012.17c|ILVB_MYCTU|Rv3003c|MT3083|MTV012.17c,
showbetter similarity to Acetolactate synthase I. Similar
to other enzymes which require TPP. Cofactor: thiamin
pyrophosphate (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3509c"
/db_xref="EnsemblGenomes-Tr:CCP46331"
/db_xref="GOA:O53554"
/db_xref="InterPro:IPR011766"
/db_xref="InterPro:IPR012001"
/db_xref="InterPro:IPR029061"
/db_xref="UniProtKB/Swiss-Prot:O53554"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46331.1"
/translation="MNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGML
TLFEGVATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHAT
YHKKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGSQIATLILPAD
VCWSDGAHAAAGVPAQAAAAPVDVGPVAGVLRSGEPAMMLIGGDATRGPGLTAAARIV
QATGARWLCETFPTCLERGAGIPAVERLAYFAEGAAAQLDGVKHLVLAGARSPVSFFA
YPGMPSDLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVAGASRPQLPTGDLTS
VSAADVVGALLPERAIVVDESNTCGVLLPQATAGAPAHDWLTLTGGAIGYGIPAAVGA
AVAAPDRPVLCLESDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAG
SDPGPKALDLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPGPHLIDV
VVPSLVG"
gene complement(3938421..3939257)
/locus_tag="Rv3510c"
CDS complement(3938421..3939257)
/codon_start=1
/transl_table=11
/locus_tag="Rv3510c"
/product="Conserved protein"
/note="Rv3510c, (MTV023.17), len: 278 aa. Conserved
protein, similar to Q50662|Rv2303c|MTCY339.06 hypothetical
34.6 KDA protein from Mycobacterium tuberculosis (307
aa),FASTA scores: opt: 416, E(): 1.2e-19, (35.7% identity
in 255 aa overlap). Middle of the putative protein highly
similar to N-terminal end of Q49860|B229_C2_182
hypothetical 11.0 KDA protein from Mycobacterium leprae
(95 aa), FASTA scores: opt: 304, E(): 7.9e-13, (83.65%
identity in 55 aa overlap). Also some similarity with
other bacterial proteins e.g. P95886 ORF C02006 from
Sulfolobus solfataricus (269 aa), FASTA scores: opt: 293,
E(): 9.6e-12, (31.3% identity in 198 aa overlap);
Q9XDF3|NONC NONC protein from Streptomyces griseus subsp.
griseus (317 aa), FASTA scores: opt: 270, E(): 3.4e-10,
(29.95% identity in 227 aa overlap); Q54229|NONR
macrotetrolide antibiotic-resistance protein from
Streptomyces griseus (347 aa), FASTA scores: opt: 270,
E(): 3.6e-10, (29.95% identity in 227 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3510c"
/db_xref="EnsemblGenomes-Tr:CCP46332"
/db_xref="GOA:I6Y3Q7"
/db_xref="InterPro:IPR006680"
/db_xref="InterPro:IPR032465"
/db_xref="InterPro:IPR032466"
/db_xref="UniProtKB/TrEMBL:I6Y3Q7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46332.1"
/translation="MTIDVWMQHPTQRFLHGDMFASLRRWTGGSIPETDIPIEATVSS
MDAGGVTLGLLSAWRGPNGQDLISNDAVAEWVRLYPNRFAGLAAVDLDRPMAAVRELR
RRVGEGFVGLRVVPWLWGAPPTDRRYYPLFAECVQSAVPFCTQVGHTGPLRPSETGRP
IPYIDQVALDFPELVIVCGHVGYPWTEEMVAVARKHENVYIDTSAYTIKRLPGKLVRF
MKTDTGQRKVLFGTNYPMIAHTHALTGLDELGLSDEARRDFLHGNAVRVFKLDPRGKV
QT"
gene 3939617..3941761
/gene="PE_PGRS55"
/locus_tag="Rv3511"
CDS 3939617..3941761
/codon_start=1
/transl_table=11
/gene="PE_PGRS55"
/locus_tag="Rv3511"
/product="PE-PGRS family protein PE_PGRS55"
/note="Rv3511, (MTV023.18), len: 714 aa. PE_PGRS55, Member
of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see Brennan and Delogu,
2002),similar to others from Mycobacterium tuberculosis
strains H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa)
FASTA scores: opt: 2563, E(): 1.5e-94, (59.65% identity in
773 aa overlap); and upstream O53553|Rv3508|MTV023.15
(1901 aa),FASTA scores: opt: 2455, E(): 3.9e-90, (60.4%
identity in 737 aa overlap); etc. Contains PS00583 pfkB
family of carbohydrate kinases signature 1."
/db_xref="EnsemblGenomes-Gn:Rv3511"
/db_xref="EnsemblGenomes-Tr:CCP46333"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MWW8"
/inference="protein motif:PROSITE:PS00583"
/protein_id="CCP46333.1"
/translation="MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQVLAAGA
DEVSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYMLAEATNVEQNLLNL
INAPTQTLLGRPLIGDGANATTPGGAGGDGGLLFGSGGNGAPGAPGQAGGAGGSAGLL
GNGGSGGAGGTGAPGGNGGNAGWLYGRGGVGGAGGIGGGTGGAGGHAWLFGHGGTGGI
GGGPGGNGGWLLGNGGHGGAGGIGGGSGGAGGNGGWLLGNGGIGGAGGTGGGAGGTGG
NAAWLLGGGGTGGAGGIGGGNGGHGGNGGWLLGNGGNGGLGGDGDGGTGGGHGGNGGN
PGWLLGTAGGGGNGGAGSTGTAGGGSGGTGGDGGTGGRGGLLMGAGAGGHGGTGGAGG
AGVNGGGAGGAGGAGGNGGAGGQAALLFGRGGTGGAGGYGGDGGGGGDGFDGTMAGLG
GTGGSGGTGGDGGAPGNGGAGGAGQLLSHSGVAGASGKGGAGGTGGNGGAGSAGADAP
AGSGAMGSTGFAGGAGGDGGNGGGSGASQGNGGNGGNGGTGGKGGTGGAGMNSLDPLL
AAQDGGQGGTGGTGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGT
TGGAGGAGGAGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQD
GGQGGTGGTGGNAGAGGTGFTPRRRRQRRQRR"
gene <3941724..3944963
/gene="PE_PGRS56"
/locus_tag="Rv3512"
CDS <3941724..3944963
/codon_start=1
/transl_table=11
/gene="PE_PGRS56"
/locus_tag="Rv3512"
/product="PE-PGRS family protein PE_PGRS56"
/note="Rv3512, (MTV023.19), len: 1079 aa. PE_PGRS56,
Member of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
similar to others from Mycobacterium tuberculosis strains
H37Rv and CDC1551 e.g. AAK47974|MT3615.3 (1217 aa) FASTA
scores: opt: 3688, E(): 4.5e-130, (53.95% identity in 1136
aa overlap); and downstream O53559|Rv3514|MTV023.21 (1489
aa), FASTA scores: opt: 3611, E(): 3.6e-127, (53.15%
identity in 1195 aa overlap); etc. Frameshifted PGRS
protein, could be continuation of upstream MTV023.18, but
no error could be found."
/db_xref="EnsemblGenomes-Gn:Rv3512"
/db_xref="EnsemblGenomes-Tr:CCP46334"
/db_xref="GOA:Q6MWW7"
/db_xref="UniProtKB/TrEMBL:Q6MWW7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46334.1"
/translation="PQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGA
GGTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGDA
GKAGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGTGGSGGAGGTGGDGGA
ANGGTAGAGGAGGNGGKGGDGGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGAN
GIAGNGGDGGDGAAGAVGISGATGAGDGGHGGTGAAGGNGGTGGAGGSGIDGVGGGTG
GTGGNGGNGAIGGAGGDAGGSGNSGGNGGIGGKGGNAGAGGAAGSNGGTVGANGTGGD
GGNGGAAGAATAGSNGGAGTGSAGGNGGTGGRGGSGGAGGDGIGGVGGGKGGNGADGE
VGGAGGAGGSGPNTSPGGNGGQGGQGGSGGAGGAAGAGGAGGGANGTAGNGGQGGAGG
TGGAGAASSATNGGSGGAGGTGGDGGSGGAGGTGGAGGTGGAAGDGGQGGQGGAGGGA
GGQGGAGGAGGTGGNGGNITGGTAGTAGAAGNGGAAGKGGAGGQGGTGGGTGGQGGAG
GDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQGGADGGSGGDGGDAGTGGNG
GNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGGGTGGNGGAGGDAGDAGNGGNGNG
TGNGGNGGNGGIAGMGGNGGAGTGSGNGGNGGSGGNGGNAGMGGNSGTGSGDGGAGGN
GGAAGTGGTGGDGGLTGTGGTGGSGGTGGDGGNGGNGADNTANMTAQAGGDGGNGGDG
GFGGGAGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTG
GTGGAGIGSLGGGTGGDGGNGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGD
GGAGGTGGTGGTGGLGDPRVGGSGGDGGTGGSGGAAGNGGNGGNAGAGGNGNGGTGGA
GGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGG
GNGGTGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV"
gene complement(3945092..3945748)
/gene="fadD18"
/locus_tag="Rv3513c"
CDS complement(3945092..3945748)
/codon_start=1
/transl_table=11
/gene="fadD18"
/locus_tag="Rv3513c"
/product="Probable fatty-acid-CoA ligase FadD18 (fragment)
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv3513c, (MTV023.20c), len: 218 aa (Start
uncertain). Probable fadD18, fatty-acid-CoA synthetase
(C-terminal fragment), almost identical to C-terminal end
of downstream O53560|FADD19|Rv3515c|MTV023.22c, probably
result of partial gene duplication. Also similar at the
C-terminus to other fatty-acid-CoA synthetases e.g.
Q9EXL2|FADD from Streptomyces griseus (540 aa), FASTA
scores: opt: 586, E(): 1.2e-28, (52.45% identity in 185 aa
overlap); AAB87139|MIG medium chain acyl-CoA synthetase
precursor from Mycobacterium avium (550 aa), FASTA scores:
opt: 506, E(): 9.5e-24, (50.0% identity in 150 aa
overlap); Q9A7C3|CC1801 putative 4-coumarate--CoA ligase
from Caulobacter crescentus (561 aa), FASTA scores: opt:
430,E(): 4.4e-19, (45.75% identity in 153 aa overlap);
Q9KDT0|BH1131 acid-CoA ligase from Bacillus halodurans
(546 aa), FASTA scores: opt: 338, E(): 1.9e-13, (38.05%
identity in 142 aa overlap); Q9RTR4|DR1692 long-chain
fatty acid--CoA ligase from Deinococcus radiodurans (584
aa),FASTA scores: opt: 331, E(): 5.3e-13, (35.15% identity
in 145 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3513c"
/db_xref="EnsemblGenomes-Tr:CCP46335"
/db_xref="GOA:I6YGC8"
/db_xref="InterPro:IPR025110"
/db_xref="UniProtKB/TrEMBL:I6YGC8"
/protein_id="CCP46335.1"
/translation="MAASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQA
VRPARTLAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGS
VSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS
"
repeat_region complement(3945098..3945597)
/gene="fadD18"
/locus_tag="Rv3513c"
/note="500 bp perfect direct repeat 2; second copy at
3950830..3951329."
gene 3945794..3950263
/gene="PE_PGRS57"
/locus_tag="Rv3514"
CDS 3945794..3950263
/codon_start=1
/transl_table=11
/gene="PE_PGRS57"
/locus_tag="Rv3514"
/product="PE-PGRS family protein PE_PGRS57"
/note="Rv3514, (MTV023.21), len: 1489 aa. PE_PGRS57,
Member of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins (see citation below),
similar to others from Mycobacterium tuberculosis strains
H37Rv and CDC1551 e.g. AAK47971 (1715 aa) FASTA scores:
opt: 6940,E(): 0, (67.0% identity in 1713 aa overlap); and
upstream O53553|YZ08_MYCTU|Rv3508|MTV023.15 (1901 aa),
FASTA scores: opt: 6598,E(): 0, (71.05% identity in 1533
aa overlap). Contains two PS00583 pfkB family of
carbohydrate kinases signatures 1."
/db_xref="EnsemblGenomes-Gn:Rv3514"
/db_xref="EnsemblGenomes-Tr:CCP46336"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MWW6"
/inference="protein motif:PROSITE:PS00583"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46336.1"
/translation="MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQVLAAGA
DEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYASAEAAAAEQIVLGV
INAPTQALLGRPLIGDGANATTPGGAGGAGGLLFGNGGAGAAGAPGQAGGPGGPAGLW
GNGGPGGAGGSGGGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAG
GVGGAGGGTGGAGGRAELLFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLAPGGA
GGAGGQGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQGG
TGGAGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQLFSASGAAGNAGVGGAGGQGG
DGGAGGAGADADQPGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGQGGAGGAGG
AGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGQGGDG
GAGGAGADADQPGATGGTGFAGGAGGAGGAGGSSGAGGTNGSGGAGGTGGQGGAGGAG
GAGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGQGGD
GGAGGAGADADQPGATGGTGFAGGAGGAGKAGGSSSAGGTNSSGSAGGTGRQSGTGGA
GGAGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTGGTGGMIGTTGNAGVGGAGGSSG
AGGTNGSGGAGGTDGQGGAGGAGGAGADNPTGIGGTGGDGGTGGAAGAGGAGGAAGTG
GTGGMIGTTGNAGVGGAGGQGGDGGAGGAGADADQPGATGGTGFAGGAGGAGGSGGSS
CAGGTNGSGGAGGTCGQVVAGGAGISFSNGSNGGTGGTGGVGGTGGDGGNAGTGAGDP
GKGGTGGTGGTGGSGGAGGSGGANFNGGTGGTGGTGGKGGLNTDGLSSATSGTGGTGG
TGGKGGTGGAGDDSAGGTGGTGGAGGNAGAGGLANTGGTAGNAGIGGDGGQGGNGGQG
DSGSGLGGQPGFAGGAGGKGGAGGSSGAGGTNGSGGAGGAGGQGGAGGAGISFSNGSN
GGTGGTGGVGGTGGDGGNAGTGAGDPGKGGTGGTGGTGGSGGAGGSGGANFNGGTGGT
GGTGGTGGKGGMGGIAGDGGPGGDGGNAGVGGKGGTNGNGGSGGTGGTGGAGGNAGAG
GLANTGGTAGNAGIGGDGGQGGNGGQGDSGSGLGGQPGFAGGPGGKGGAGGNAGTGGT
NGSGAGGAGGQGGAGGAGISFSNGSNGGTGGTGGVGGTGGDGGNAGTGAGDPGKGGTG
GTGGTGGSGGAGGSGGANFNGGTGGTGGTGGTGGKGGMGGIAGDGGPGGDGGNAGVGG
KGGTNGNGGSGGTGGTGGPGGSGGAPTGSGTGGKGGAGGDGGDGADGGAATGVGDGGD
GGNGGNGGNGGTGVGSPGGLGGAGGTGGLGGAGAGGGADGDDGDDGQPGNNGS"
gene complement(3950824..3952470)
/gene="fadD19"
/locus_tag="Rv3515c"
CDS complement(3950824..3952470)
/codon_start=1
/transl_table=11
/gene="fadD19"
/locus_tag="Rv3515c"
/product="Fatty-acid-CoA ligase FadD19 (fatty-acid-CoA
synthetase) (fatty-acid-CoA synthase)"
/note="Rv3515c, (MTV023.22c), len: 548 aa.
fadD19,fatty-acid-CoA synthetase, similar (or with
similarity) to many e.g. Q9EXL2|FADD FADD protein from
Streptomyces griseus (540 aa), FASTA scores: opt: 1449,
E(): 1.5e-81,(46.0% identity in 535 aa overlap);
AAB87139|MIG medium chain acyl-CoA synthetase precursor
from Mycobacterium avium (550 aa), FASTA scores: opt:
1226, E(): 7.6e-68,(40.7% identity in 543 aa overlap);
Q9A7C3|CC1801 putative 4-coumarate--CoA ligase from
Caulobacter crescentus (561 aa), FASTA scores: opt: 979,
E(): 1.2e-52, (34.05% identity in 531 aa overlap);
O28502|AF1772 long-chain-fatty-acid--CoA ligase (FADD-7)
from Archaeoglobus fulgidus (569 aa), FASTA scores: opt:
560,E(): 6.9e-27, (29.3% identity in 543 aa overlap);
Q9A8N2|CC1321 long-chain-fatty-acid--CoA ligase from
Caulobacter crescentus (583 aa), FASTA scores: opt:
544,E(): 6.7e-26, (27.2% identity in 518 aa overlap);
P29212|LCFA_ECOLI|FADD|OLDD|B1805
long-chain-fatty-acid--CoA ligase from Escherichia coli
strain K12 (561 aa), FASTA scores: opt: 460, E():
4e-22,(26.3% identity in 567 aa overlap); etc. Contains
PS00455 Putative AMP-binding domain signature. Note that
upstream MTV023.20c|Rv3513c|fadD18 is identical to
C-terminal part of FADD19|Rv3515c|MTV023.22c (probably
result of partial gene duplication)."
/db_xref="EnsemblGenomes-Gn:Rv3515c"
/db_xref="EnsemblGenomes-Tr:CCP46337"
/db_xref="GOA:P9WQ51"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ51"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46337.1"
/translation="MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLA
HHLIDQGVQKDDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSD
MVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPERD
FGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAA
ANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAPEFNADEVWRTIHKHKVNLLFFT
GDAMARPLVDALVKGNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSE
TGFGGTSVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYY
KDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAA
LKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSL
WFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG"
repeat_region complement(3950830..3951329)
/gene="fadD19"
/locus_tag="Rv3515c"
/note="500 bp perfect direct repeat 1; second copy at
3945098..3945597."
gene 3952544..3953335
/gene="echA19"
/locus_tag="Rv3516"
CDS 3952544..3953335
/codon_start=1
/transl_table=11
/gene="echA19"
/locus_tag="Rv3516"
/product="Possible enoyl-CoA hydratase EchA19 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv3516, (MTV023.23), len: 263 aa. Possible
echA19,enoyl-CoA hydratase, similar to other e.g.
Q9ZHG2|ECHA1 from Rhodococcus fascians (275 aa) FASTA
scores: opt: 613,E(): 6.4e-32, (45.15% identity in 259 aa
overlap); P76082|PAAF_ECOLI|B1393 from Escherichia coli
strain K12 (255 aa), FASTA scores: opt: 523, E(): 3.3e-26,
(33.6% identity in 256 aa overlap); Q9I393|PA1629 from
Pseudomonas aeruginosa (261 aa), FASTA scores: opt: 475,
E(): 3.8e-23,(36.85% identity in 247 aa overlap); etc.
Also similar to many carnitine racemases eg
BAB52369|MLL6015 from Rhizobium loti (Mesorhizobium loti)
(257 aa), FASTA scores: opt: 546,E(): 1.1e-27, (36.65%
identity in 251 aa overlap). Similar to several putative
enoyl-CoA hydratases from Mycobacterium tuberculosis, e.g.
P96404|ECHA1|Rv0222|MTCY08D5.17 (262 aa), FASTA scores:
opt: 630, E(): 5.1e-33, (44.5% identity in 254 aa
overlap); and O53783|ECHA5|Rv0675|MTV040.03 (263 aa) FASTA
scores: opt: 499, E(): 1.1e-24, (40.5% identity in 252 aa
overlap). Could belong to the enoyl-CoA
hydratase/isomerase family."
/db_xref="EnsemblGenomes-Gn:Rv3516"
/db_xref="EnsemblGenomes-Tr:CCP46338"
/db_xref="GOA:O53561"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:O53561"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46338.1"
/translation="MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRV
DNDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYGPSRIDALLKGRRLTKP
LIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTL
ACDLLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIR
ETECMPENEAFKIDTQIGIKVFLSDDAKEGPRAFAEKRAPNFQNR"
gene 3953431..3954270
/locus_tag="Rv3517"
CDS 3953431..3954270
/codon_start=1
/transl_table=11
/locus_tag="Rv3517"
/product="Conserved hypothetical protein"
/note="Rv3517, (MTV023.24), len: 279 aa. Hypothetical
protein, similar to several hypothetical mycobacterial
proteins e.g. P71763|Rv1482c|MTCY277.03c from
Mycobacterium tuberculosis strain H37Rv (339 aa) (alias
AAK45794|MT1529 from Mycobacterium tuberculosis strain
CDC1551 (292 aa) but longer) FASTA scores: opt: 1040, E():
3.7e-60, (59.0% identity in 273 aa overlap); O07396|MAV346
from Mycobacterium avium (346 aa) FASTA scores: opt: 1018,
E(): 1e-58, (57.2% identity in 278 aa overlap);
O53421|Rv1073|MTV017.26 from Mycobacterium tuberculosis
strain H37Rv (283 aa), FASTA scores: opt: 903, E():
2.4e-51, (48.0% identity in 277 aa overlap);
Q50134|U650AG|MLCB57.67c from Mycobacterium leprae (75 aa)
FASTA scores: opt: 158, E(): 0.0015, (41.8% identity in 55
aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3517"
/db_xref="EnsemblGenomes-Tr:CCP46339"
/db_xref="GOA:O53562"
/db_xref="UniProtKB/TrEMBL:O53562"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46339.1"
/translation="MIEPFLGSEAIASGALTRHRLRSAYATIHPDVYVSPGADLTAWS
RAQAAWLWSRRRGVIAGQSAAAMHGAKWVDARQAAELLYDHRRPPAGIHTWSDRVADD
EIQPISGMNTTTPARTALDLARRYPVGKAVAAIDALARATDLKLADVEMLAERYRGSR
GIRNARIALDLVDPGAESPRETWLRLLLIRAGFPRPQTQIPVYDEYGQLVAVIDMGWA
GIKVGVDYEGDHHRTDRRTFNKDIKRAEALTELGWTDVRVTVEDTEGGIIWRVSAAWQ
RRT"
gene complement(3954325..3955521)
/gene="cyp142"
/locus_tag="Rv3518c"
CDS complement(3954325..3955521)
/codon_start=1
/transl_table=11
/gene="cyp142"
/locus_tag="Rv3518c"
/product="Probable cytochrome P450 monooxygenase 142
Cyp142"
/note="Rv3518c, (MTV023.25c), len: 398 aa. Probable
cyp142,cytochrome P450 monoxygenase, member of Cytochrome
P450 family and similar to many e.g. Q9L465|CYP162A1|NIKQ
from Streptomyces tendae (396 aa) FASTA scores: opt: 798,
E(): 2e-43, (36.7% identity in 403 aa overlap);
P33271|CPXK_SACER|CYP107B1 from Saccharopolyspora
erythraea (Streptomyces erythraeus) (405 aa), FASTA
scores: opt: 725,E(): 9.1e-39, (37.1% identity in 407 aa
overlap); Q9X8Q3|CYP107P1|SCH10.14c from Streptomyces
coelicolor (411 aa), FASTA scores: opt: 691, E(): 1.3e-36,
(37.2% identity in 317 aa overlap); etc. Also similar to
Q50696|C124_MYCTU|CYP124|Rv2266|MT2328|MTCY339.44c from
Mycobacterium tuberculosis strain H37Rv (428 aa) FASTA
scores: opt: 692, E(): 1.2e-36, (36.8% identity in 402 aa
overlap). Equivalent to AAK47979 from Mycobacterium
tuberculosis strain CDC1551 (372 aa) but longer 26 aa.
Contains PS00086 Cytochrome P450 cysteine heme-iron ligand
signature. Belongs to the cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv3518c"
/db_xref="EnsemblGenomes-Tr:CCP46340"
/db_xref="GOA:P9WPL5"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:2XKR"
/db_xref="UniProtKB/Swiss-Prot:P9WPL5"
/inference="protein motif:PROSITE:PS00086"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46340.1"
/translation="MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAAS
TYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
EASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLV
TFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDD
ELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAP
VKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFG
FGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFT
PSPPLG"
gene 3955550..3956260
/locus_tag="Rv3519"
CDS 3955550..3956260
/codon_start=1
/transl_table=11
/locus_tag="Rv3519"
/product="Unknown protein"
/note="Rv3519, (MTV023.26), len: 236 aa (start uncertain).
Unknown protein. The C-terminal end is highly similar to
N-terminal end of AAK47980|MT3620 hypothetical 7.8 KDA
protein from Mycobacterium tuberculosis strain CDC1551 (73
aa), FASTA scores: opt: 279, E(): 9.4e-12, (95.65%
identity in 46 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3519"
/db_xref="EnsemblGenomes-Tr:CCP46341"
/db_xref="GOA:O53564"
/db_xref="InterPro:IPR010451"
/db_xref="InterPro:IPR023375"
/db_xref="UniProtKB/TrEMBL:O53564"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46341.1"
/translation="MPVSQHTIAGTVLTMPVRIRTANLHSAMFSVPADPAQRLIDYSG
LRVCEYLPGKAIVMQMLVRYVDGDLGRYHEYGTAIMVNPPGTQRRGPRALTRAAAFIH
HLPVDQVFTLEAGRTIWGFPKIMADFNVTDGRRFGFDVSADGRLIAGIEFSTGLPVPT
LGWQMLKTYSHHDGVTREIPWEMKVSGLRARLGGARLRLGDHPYAKELASLGLPKRAL
LSQSAANVEMTFGDGHPI"
gene complement(3956325..3957368)
/locus_tag="Rv3520c"
CDS complement(3956325..3957368)
/codon_start=1
/transl_table=11
/locus_tag="Rv3520c"
/product="Possible coenzyme F420-dependent oxidoreductase"
/note="Rv3520c, (MTV023.27c), len: 347 aa. Possible
coenzyme F420-dependent oxidoreductase, equivalent to
Q9CCV8|ML0348 possible coenzyme F420-dependent
oxidoreductase from Mycobacterium leprae (350 aa), FASTA
scores: opt: 2029, E(): 9.1e-120, (86.85% identity in 342
aa overlap). Similar to many coenzyme F420-dependent
enzymes (and other proteins) e.g. Q9AD98|SCI52.11c
putative ATP/GTP-binding protein from Streptomyces
coelicolor (351 aa), FASTA scores: opt: 859, E(): 1.6e-46,
(41.9% identity in 346 aa overlap); Q9X7Y1|SC6A5.35
putative oxidoreductase from Streptomyces coelicolor (341
aa), FASTA scores: opt: 800, E(): 7.9e-43, (38.95%
identity in 339 aa overlap); Q9ZA30|GRA-ORF29 putative
FMN-dependent monooxygenase from Streptomyces
violaceoruber (343 aa), FASTA scores: opt: 354, E():
6.7e-15, (34.2% identity in 336 aa overlap); Q49598|mer
coenzyme F420-dependent
N5,N10-methylenetetrahydromethanopterin reductase from
Methanopyrus kandleri (349 aa), FASTA scores: opt:
283,E(): 1.9e-10, (26.75% identity in 329 aa overlap);
Q58929|mer|MJ1534 F420-dependent
methylenetetrahydromethanopterin reductase from
Methanococcus jannaschii (331 aa), FASTA scores: opt:
227,E(): 5.8e-07, (26.35% identity in 334 aa overlap);
O27784|MTH1752 coenzyme F420-dependent N5,N10-methylene
tetrahydromethanopterin reductase from Methanobacterium
thermoautotrophicum (321 aa), FASTA scores: opt: 207, E():
1e-05, (27.4% identity in 336 aa overlap); etc. Also
similar to Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24
hypothetical 37.3 KDA protein from Mycobacterium
tuberculosis (340 aa), FASTA scores: opt: 313, E():
2.5e-12, (28.0% identity in 311 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3520c"
/db_xref="EnsemblGenomes-Tr:CCP46342"
/db_xref="GOA:O53565"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR019951"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/Swiss-Prot:O53565"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46342.1"
/translation="MEAGMKLGLQLGYWGAQPPQNHAELVAAAEDAGFDTVFTAEAWG
SDAYTPLAWWGSSTQRVRLGTSVIQLSARTPTACAMAALTLDHLSGGRHILGLGVSGP
QVVEGWYGQRFPKPLARTREYIDIVRQVWARESPVTSAGPHYRLPLTGEGTTGLGKAL
KPITHPLRADIPIMLGAEGPKNVALAAEICDGWLPIFYSPRMAGMYNEWLDEGFARPG
ARRSREDFEICATAQVVITDDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMGYT
QVVDEVTKLFRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQMAVWEAAGVTMMVVTA
GSAEQVRDLAALV"
gene 3957521..3958432
/locus_tag="Rv3521"
CDS 3957521..3958432
/codon_start=1
/transl_table=11
/locus_tag="Rv3521"
/product="Conserved hypothetical protein"
/note="Rv3521, (MTV023.28), len: 303 aa. Conserved
hypothetical protein, similar to (although longer than)
other conserved hypothetical proteins e.g. O29296|AF0966
from Archaeoglobus fulgidus (176 aa), FASTA scores: opt:
286, E(): 5.4e-11, (31.15% identity in 170 aa overlap);
O30036|AF0203 from Archaeoglobus fulgidus (149 aa) FASTA
scores: opt: 259, E(): 2.3e-09, (33.8% identity in 142 aa
overlap); O29297|AF0965 from Archaeoglobus fulgidus (154
aa), FASTA scores: opt: 241, E(): 3.2e-08, (31.4% identity
in 137 aa overlap); Q9Y995|APE2390 from Aeropyrum pernix
(157 aa), FASTA scores: opt: 204, E(): 6.8e-06, (27.45%
identity in 153 aa overlap); BAB60424|TVG1322512 from
Thermoplasma volcanium (164 aa), FASTA scores: opt:
183,E(): 0.00015, (29.75% identity in 148 aa overlap);
etc. Equivalent to AAK47982 from Mycobacterium
tuberculosis strain CDC1551 (334 aa) but shorter 31 aa."
/db_xref="EnsemblGenomes-Gn:Rv3521"
/db_xref="EnsemblGenomes-Tr:CCP46343"
/db_xref="InterPro:IPR002878"
/db_xref="InterPro:IPR012340"
/db_xref="UniProtKB/TrEMBL:O53566"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46343.1"
/translation="MGPTLSRFFTALRARRIVGVRGSDGRVHVPPVEYDPVTYEPLSE
MVPVSSVGTVASWTWQPEPLAGQPLDRPFAWALIKLDGADTLLMHAVDVGTAGPSAIH
TGARVHAHWADQPVGAITDIACFALGETAEPVAAHKTEDARDPVTMIVTPIQLEIQHT
ASHEESAYLRAIAQGKLVGARTGKTGKVYFPPHGADPATGKPTSEFVELPDKGTVTTF
AIVNIPFLGQRIKPPYVAAYVLLDGADIPFLHLVSDVDAHQVRMGMRVEAVWKPRERW
GLGIDNIEYFRPTGEPDANYDTYKHHL"
gene 3958448..3959512
/gene="ltp4"
/locus_tag="Rv3522"
CDS 3958448..3959512
/codon_start=1
/transl_table=11
/gene="ltp4"
/locus_tag="Rv3522"
/product="Possible lipid transfer protein or keto acyl-CoA
thiolase Ltp4"
/note="Rv3522, (MTV023.29), len: 354 aa. Possible
ltp4,lipid carrier protein or keto acyl-CoA thiolase,
similar to several e.g. O30103|AF0134 3-ketoacyl-CoA
thiolase (ACAB-4) from Archaeoglobus fulgidus (398 aa)
FASTA scores: opt: 352, E(): 5.3e-15, (30.45% identity in
381 aa overlap); O29295|AF0967 3-ketoacyl-CoA thiolase
(ACAB-9) from Archaeoglobus fulgidus (400 aa) FASTA
scores: opt: 312,E(): 1.8e-12, (28.05% identity in 367 aa
overlap); O29294|AF0968 3-ketoacyl-CoA thiolase (ACAB-10)
from Archaeoglobus fulgidus (388 aa), FASTA scores: opt:
293,E(): 2.9e-11, (25.9% identity in 309 aa overlap);
O58409|PH0676 long hypothetical nonspecific lipid-transfer
protein (acethyl CoA synthetase) from Pyrococcus
horikoshii (389 aa), FASTA scores: opt: 292, E(): 3.3e-11,
(25.8% identity in 368 aa overlap); Q9Y9A3|APE2382 long
hypothetical non specific lipid-transfer protein from
Aeropyrum pernix (360 aa) FASTA scores: opt: 270, E():
7.8e-10, (27.25% identity in 363 aa overlap);
Q9YDI4|APE0929 long hypothetical nonspecific
lipid-transfer protein from Aeropyrum pernix (400 aa),
FASTA scores: opt: 258, E(): 4.9e-09, (26.45% identity in
306 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3522"
/db_xref="EnsemblGenomes-Tr:CCP46344"
/db_xref="GOA:O53567"
/db_xref="InterPro:IPR016039"
/db_xref="UniProtKB/TrEMBL:O53567"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP46344.1"
/translation="MSVRDIAVVGFAHAPHVRRTDGTTNGVEMLMPCFAQLYDELGIT
KADIGFWCSGSSDYLAGRAFSFISAIDSIGAVPPINESHVEMDAAWALYEAYIKLLTG
EVDTALVYGFGKSSAGTLRRVLSRQTDPYTVAPLWPDSVSMAGLQARLGLDSGKWTHE
QMARVAFDSFTNARRVDSVEPPITVGELLARPFFADPLRRHDIAPITDGAAAVVLAAD
NRARELRENPAWITGIEHRIESPALGARDITESPSTKLAAKIATGGHTGDIDVAEIHG
PFTHQHLIVAEAIRIPGKTKVNPSGGPLAANPMFAAGLERIGFAAQHTWDGSARRVLA
HATSGPALQQNLVAVMEGRG"
gene 3959529..3960713
/gene="ltp3"
/locus_tag="Rv3523"
CDS 3959529..3960713
/codon_start=1
/transl_table=11
/gene="ltp3"
/locus_tag="Rv3523"
/product="Probable lipid carrier protein or keto acyl-CoA
thiolase Ltp3"
/note="Rv3523, (MTCY03C7.33c), len: 394 aa. Probable
ltp3,lipid carrier protein or keto acyl-CoA thiolase,
similar to several e.g. O30037|AF0202 3-ketoacyl-CoA
thiolase (ACAB-6) from Archaeoglobus fulgidus (380 aa)
FASTA scores: opt: 782, E(): 1.7e-40, (38.35% identity in
386 aa overlap); Q9Y9A1|APE2384 long hypothetical non
specific lipid-transfer protein (acethyl CoA synthetase)
from Aeropyrum pernix (394 aa), FASTA scores: opt: 626,
E(): 5.9e-31, (35.75% identity in 386 aa overlap);
BAB59210|TVG0067506 lipid transfer protein from
Thermoplasma volcanium (390 aa), FASTA scores: opt:
591,E(): 8.1e-29, (34.35% identity in 384 aa overlap);
Q9YDI4|APE0929 long hypothetical nonspecific
lipid-transfer protein from Aeropyrum pernix (400 aa)
FASTA scores: opt: 588, E(): 1.3e-28, (31.6% identity in
408 aa overlap); O30104|AF0133 3-ketoacyl-CoA thiolase
(ACAB-3) from Archaeoglobus fulgidus (411 aa) FASTA
scores: opt: 583,E(): 2.6e-28, (39.8% identity in 412 aa
overlap); O29811|AF0438 3-ketoacyl-CoA thiolase (ACAB-8)
from Archaeoglobus fulgidus (387 aa), FASTA scores: opt:
574,E(): 8.8e-28, (30.95% identity in 388 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3523"
/db_xref="EnsemblGenomes-Tr:CCP46345"
/db_xref="GOA:I6YGD8"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="UniProtKB/TrEMBL:I6YGD8"
/protein_id="CCP46345.1"
/translation="MAGKLAAVLGTGQTKYVAKRQDVSMNGLVREAIDRALADSGSTF
DDIDAVVVGKAPDFFEGVMMPELFMADAMGATGKPLIRVHTAGSVGGSTGVVAASLVQ
SGKYRRVLALAWEKQSESNAMWALSIPVPFTKPVGAGAGGYFAPHVRAYIRRSGAPAH
IGAMVAVKDRLNGSRNPLAHLQQPDITLEKVMASQMLWDPIRFDETCPSSDGACAVVV
GDEEIADARLAQGHPVAWIHGTALRTEPLAFAGRDQVNPQAGRDAAAALWKAAGITSP
IDEIDAAEIYVPFSWFEPMWLENLGFAREGEGWKLTEAGETAIGGRLPVNPSGGVLSA
NPIGASGLIRFAEAAIQVMGKAEARQVPGARKALGHAYGGGSQYFSMWVVGCEKPKQA
AA"
gene 3960755..3961786
/locus_tag="Rv3524"
CDS 3960755..3961786
/codon_start=1
/transl_table=11
/locus_tag="Rv3524"
/product="Probable conserved membrane protein"
/note="Rv3524, (MTCY03C7.32c), len: 343 aa. Probable
conserved membrane protein, showing some similarity to
C-terminal part of putative Mycobacterium tuberculosis
proteins O05871|P95308|PKND_MYCTU|Rv0931c|MT0958|MTCY08C9.
08 serine-threonine protein kinase PknD (664 aa) FASTA
scores: opt: 727, E(): 8.3e-36, (45.3% identity in 298 aa
overlap); O53893|Rv0980c|MTV044.08c PGRS-family protein
(457 aa),FASTA scores: opt: 208, E(): 4.4e-05, (33.75%
identity in 166 aa overlap); and O53891|Rv0978c|MTV044.06c
PGRS-family protein (331 aa) FASTA scores: opt: 153, E():
0.062,(30.75% identity in 117 aa overlap). Contains
PS00237 G-protein coupled receptors signature."
/db_xref="EnsemblGenomes-Gn:Rv3524"
/db_xref="EnsemblGenomes-Tr:CCP46346"
/db_xref="InterPro:IPR001258"
/db_xref="InterPro:IPR013017"
/db_xref="InterPro:IPR035016"
/db_xref="UniProtKB/TrEMBL:I6X7J6"
/inference="protein motif:PROSITE:PS00237"
/protein_id="CCP46346.1"
/translation="MVKFTPDSQTSVLRAGKCSGTLSPSRSRLQRGSWPVDSERRRYG
WPRNRRTLAITGAAVVVVVTLAAIGYLIFEPKISGSSTSRQAASPTTPSPPSQVVVPI
DLWNPDGVTVDLADAVYVADSGHKRLLKLPAGSNTPTTLPFTDTIGPGGVAVNSNRDV
YVIDEDSHHVLKLAAGIEPPVELPFGSLGDAHGLAVDRSDSVYVVDYDNAKVLKLPPG
ADTPTELPFVGLDHPYDVAVDGAGTVYVTDSGHNRVVALTAGSATPVHLPFADLSFPA
GVTVDRDDSVYVADLNNNRVLKLAAGSNAQSQLPFTGLFSPTDVAVDNDGAVYVIDFY
NRMLKLPTA"
gene complement(3961800..3962324)
/locus_tag="Rv3525c"
CDS complement(3961800..3962324)
/codon_start=1
/transl_table=11
/locus_tag="Rv3525c"
/product="Possible siderophore-binding protein"
/note="Rv3525c, (MTCY3C7.31), len: 174 aa. Possible
siderophore-binding protein, similar to ferripyochelin
binding proteins (and related) e.g. Q9RSN5|DR2089
ferripyochelin-binding protein from Deinococcus
radiodurans (240 aa), FASTA scores: opt: 472, E():
3.3e-21, (46.9% identity in 162 aa overlap); O59257|PH1591
long hypothetical ferripyochelin binding protein from
Pyrococcus horikoshii (173 aa), FASTA scores: opt: 431,
E(): 6.7e-19,(40.0% identity in 170 aa overlap);
Q9V158|FBP|PAB0393 ferripyochelin binding protein from
Pyrococcus abyssi (173 aa), FASTA scores: opt: 429, E():
8.9e-19, (39.4% identity in 170 aa overlap);
BAB47820|MLR0180 ferripyochelin binding protein-like from
Rhizobium loti (Mesorhizobium loti) (175 aa), FASTA
scores: opt: 415, E(): 6.1e-18, (42.55% identity in 141 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3525c"
/db_xref="EnsemblGenomes-Tr:CCP46347"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR011004"
/db_xref="UniProtKB/TrEMBL:I6YCB9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46347.1"
/translation="MPLFSFEGRSPRIDPTAFVAPTATLIGDVTIEAGASVWFNAVLR
GDYAPVVVREGANVQDGAVLHAPPGIPVDIGPGATVAHLCVIHGVHVGSEALIANHAT
VLDGAVIGARCMIAAGALVVAGTQIPAGMLVTGAPAKVKGPIEGTGAEMWVNVNPQAY
RDLAARHLAGLEPM"
gene 3962439..3963599
/gene="kshA"
/locus_tag="Rv3526"
CDS 3962439..3963599
/codon_start=1
/transl_table=11
/gene="kshA"
/locus_tag="Rv3526"
/product="Oxygenase component of
3-ketosteroid-9-alpha-hydroxylase KshA"
/note="Rv3526, (MTCY03C7.30c), len: 386 aa. kshA,
oxygenase component of 3-ketosteroid-9-alpha-hydroxylase,
highly similar, except in C-terminus (also longer 69 aa),
to O69348|ORF12 protein (function unknown) from
Rhodococcus erythropolis (316 aa) FASTA scores: opt: 1137,
E(): 6.9e-65, (59.6% identity in 250 aa overlap). Also
some similarity with several aminopyrrolnitrin oxidases
(PRND proteins, involved in the pathway for pyrrolnitrin
biosynthesis, a secondary metabolite derived from
tryptophan which has strong anti-fungal activity) e.g.
Q9RPG0|PRND from Myxococcus fulvus (379 aa), FASTA scores:
opt: 322, E(): 4.4e-13, (25.85% identity in 352 aa
overlap); Q9RPG4|PRND from Burkholderia cepacia
(Pseudomonas cepacia) (373 aa) FASTA scores: opt: 306,
E(): 4.5e-12, (25.2% identity in 373 aa overlap);
P95483|PRND from Pseudomonas fluorescens (363 aa), FASTA
scores: opt: 305, E(): 5.1e-12, (25.0% identity in 372 aa
overlap); etc. And also some similarity to other putative
enzymes like dioxygenases, oxidases, vanillate O-demethyl
oxygenase,etc."
/db_xref="EnsemblGenomes-Gn:Rv3526"
/db_xref="EnsemblGenomes-Tr:CCP46348"
/db_xref="GOA:P71875"
/db_xref="InterPro:IPR017941"
/db_xref="InterPro:IPR036922"
/db_xref="PDB:2ZYL"
/db_xref="PDB:4QCK"
/db_xref="UniProtKB/Swiss-Prot:P71875"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46348.1"
/translation="MSTDTSGVGVREIDAGALPTRYARGWHCLGVAKDYLEGKPHGVE
AFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRWGGDGRCKLV
PYARRTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDPAVRIPEIPEAASDEWTDWRWN
RILIEGSNCRDIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDDLG
TSYGEAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGVIVE
KPKGMSEEMTDKLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYE
QFYVDVADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSREVSDDVPAEQH"
gene 3963605..3964054
/locus_tag="Rv3527"
CDS 3963605..3964054
/codon_start=1
/transl_table=11
/locus_tag="Rv3527"
/product="Hypothetical protein"
/note="Rv3527, (MTCY03C7.29c), len: 149 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3527"
/db_xref="EnsemblGenomes-Tr:CCP46349"
/db_xref="UniProtKB/TrEMBL:I6XHG6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46349.1"
/translation="MPDDQPAVPDVDRLARSMLLLHGDHHDHNDSPEQHRTCGSWSKS
RDFADDPQRAAAVREASRAERDRYLTSGLQPVDCRFCHVTVTVKRLGPGHTAVQWNTE
ASRRCAYFTELRARGGDSARTRSCPRLTDSIEHAVAEGYLEHHDPNR"
gene complement(3964479..3965192)
/locus_tag="Rv3528c"
CDS complement(3964479..3965192)
/codon_start=1
/transl_table=11
/locus_tag="Rv3528c"
/product="Unknown protein"
/note="Rv3528c, (MTCY03C7.28), len: 237 aa. Unknown
protein. This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3528c"
/db_xref="EnsemblGenomes-Tr:CCP46350"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:I6YGE4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46350.1"
/translation="MMLDRLRQGGYWLVRGKINLIDRAFTSCRIESFADLGAVWGVEG
AYTFRALDKYPVKEAVLVDGRITPTVAARANSYPQLRVIEGNFGDQEIADKVGNVDAL
FLFDVLLHQVSPDWDTILDMYAKNVRCLLIYNQQWIGSTTTVRLLDLGEKHYFRNVPH
SKLNKAYRDLFQKLDKKHPDHDKPWRDIPDIWQWGITDADLESKASELGFKLLYKEDC
RGFGWLPNIQNRAFLFARQ"
gene complement(3965884..3967038)
/locus_tag="Rv3529c"
CDS complement(3965884..3967038)
/codon_start=1
/transl_table=11
/locus_tag="Rv3529c"
/product="Conserved hypothetical protein"
/note="Rv3529c, (MTCY03C7.27), len: 384 aa. Conserved
hypothetical protein, showing some similarity to
Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 hypothetical
46.1 KDA protein from Mycobacterium tuberculosis (388 aa)
FASTA scores: opt: 261, E(): 1.6e-09, (27.25% identity in
253 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3529c"
/db_xref="EnsemblGenomes-Tr:CCP46351"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:I6YCC4"
/protein_id="CCP46351.1"
/translation="MTRRPDRKDVATVDELHASATKLVGLDDFGTDDDNYREALGVLL
DAYQGEAGLTVLGSKMNRFFLRGALVARLLSQSAWKQYPEHVDVAIKRPIFVTGLVRT
GTTALHRLLGADPAHQGLHMWLAEYPQPRPPRETWESNPLYRQLDAQFTQHHAENPGY
TGLHFMAAYELEECWQLLRQSLHSVSYEALAHVPSYADWLSRQDWTPSYCRHRRNLQL
IGLNDAEKRWVLKNPSHLFALDALMATYPDALVVQTHRPVETIMASMCSLAQHTTEGW
STKFVGAQIGADAMDTWSRGLERFNAARAKYDSAQFYDVDYHDLIADPLGTVADIYRH
FGLTLSDEARQAMTTVHAESQSGARAPKHSYSLADYGLTVEMVKERFAGL"
gene complement(3967038..3967820)
/locus_tag="Rv3530c"
CDS complement(3967038..3967820)
/codon_start=1
/transl_table=11
/locus_tag="Rv3530c"
/product="Possible oxidoreductase"
/note="Rv3530c, (MTCY03C7.26), len: 260 aa. Possible
oxidoreductase, similar to various oxidoreductases and
hypothetical proteins e.g. BAB53258|Q987E5|MLL7083
probable oxidoreductase from Rhizobium loti (Mesorhizobium
loti) (258 aa), FASTA scores: opt: 405, E(): 5.3e-18,
(33.45% identity in 263 aa overlap); Q9VNF3|CG12171
hypothetical protein from Drosophila melanogaster (Fruit
fly) (257 aa),FASTA scores: opt: 404, E(): 6.1e-18, (32.8%
identity in 256 aa overlap); Q9A3X5|CC3076 oxidoreductase
(short-chain dehydrogenase/reductase family) from
Caulobacter crescentus (254 aa), FASTA scores: opt: 400,
E(): 1.1e-17, (31.0% identity in 255 aa overlap);
BAB50080|MLR3115 dehydrogenase from Rhizobium loti
(Mesorhizobium loti) (259 aa), FASTA scores: opt: 393,
E(): 3e-17, (31.9% identity in 254 aa overlap);
Q9F5J1|SIM-NJ1|SIMD2 putative 3-keto-acyl-reductase from
Streptomyces antibioticus (273 aa), FASTA scores: opt:
388, E(): 6.3e-17, (31.6% identity in 250 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3530c"
/db_xref="EnsemblGenomes-Tr:CCP46352"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6Y3S9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46352.1"
/translation="MTGMLKRKVIVVSGVGPGLGTTLAHRCARDGADLVLAARSAERL
DDVAKQIIDTGRRAVAVRTDITDDDDVSNLVQATLAAYGKADVLINNAFRVPSMKPLA
GTTFEHIRDAIELSALGTLRLIQAFTPALAQSHGAIVNVNSMVIRHSQPKYGTYKMAK
SVLLAMSHSLATELGEQGIRVNSVAPGYIWGDTLKSYFDHQAGKYGTTVDQIYQATAA
NSDLKRLPTEDEVASAILFLASDLASGITGQTLDVNCGEYHT"
gene complement(3967817..3968944)
/locus_tag="Rv3531c"
CDS complement(3967817..3968944)
/codon_start=1
/transl_table=11
/locus_tag="Rv3531c"
/product="Hypothetical protein"
/note="Rv3531c, (MTCY03C7.25), len: 375 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3531c"
/db_xref="EnsemblGenomes-Tr:CCP46353"
/db_xref="UniProtKB/TrEMBL:I6XHH2"
/protein_id="CCP46353.1"
/translation="MYSDPLREAIAEAEQLVAAAPHIETEADLLEGLQYLAGCIAGCM
HLAFDYERDHPFLQSGTGPFTKMGLDNPDTLYFGTRLQANRDYVVSGRRGTTTDLSFQ
LLGGEYTDYNVPASQAAFDDRELDIAADGSFEWRLRPSAPGQLVIREVYGDWSQQRGT
LAIARLDTVGTAPPPLTRELMEKRYATAGSQLVNRVKTWLQFPQWFYLNIPVNTMVAP
RLTPGGLATQYSSAGHFELRPGQALVITVPVSDAPYLGFQLGSMWYISLDYINHQTSL
NASQAQADPDGKVRIVVAEQNPGVTNWVETLGHRRGFLQFRWQRVSRELTEADGPTVE
LVDFDAIPAALPHYQHNKISEDDWRARIALRQRQIATRMLG"
gene 3969343..3970563
/gene="PPE61"
/locus_tag="Rv3532"
CDS 3969343..3970563
/codon_start=1
/transl_table=11
/gene="PPE61"
/locus_tag="Rv3532"
/product="PPE family protein PPE61"
/note="Rv3532, (MTCY03C7.24c), len: 406 aa. PPE61, Member
of the Mycobacterium tuberculosis PPE protein
family,similar to many, e.g. O53956|Rv1807|MTV049.29 (403
aa),FASTA scores: opt: 954, E(): 1.1e-43, (44.1% identity
in 417 aa overlap)"
/db_xref="EnsemblGenomes-Gn:Rv3532"
/db_xref="EnsemblGenomes-Tr:CCP46354"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHX9"
/protein_id="CCP46354.1"
/translation="MFMDFAMLPPEVNSTRMYSGPGAGSLWAAAAAWDQVSAELQSAA
ETYRSVIASLTGWQWLGPSSVRMGAAVTPYVEWLTTTAAQARQTATQITAAATGFEQA
FAMTVPPPAIMANRAQVLSLIATNFFGQNTAAIAALETQYAEMWEQDATAMYDYAATS
AAARTLTPFTSPQQDTNSAGLPAQSAEVSRATANAGAADGNWLGNLLEEIGILLLPIA
PELTPFFLEAGEIVNAIPFPSIVGDEFCLLDGLLAWYATIGSINNINSMGTGIIGAEK
NLGILPELGSAAAAAAPPPADIAPAFLAPLTSMAKSLSDGALRGPGEVSAAMRGAGTI
GQMSVPPAWKAPAVTTVRAFDATPMTTLPGGDAPAAGVPGLPGMPASGAGRAGVVPRY
GVRLTVMTRPLSGG"
gene complement(3970705..3972453)
/gene="PPE62"
/locus_tag="Rv3533c"
CDS complement(3970705..3972453)
/codon_start=1
/transl_table=11
/gene="PPE62"
/locus_tag="Rv3533c"
/product="PPE family protein PPE62"
/note="Rv3533c, (MTCY03C7.23), len: 582 aa. PPE62, Member
of the Mycobacterium tuberculosis PPE protein
family,similar to many, e.g. O53309|Rv3159c|MTV014.03c
(590 aa) FASTA scores: opt: 2289, E(): 2.3e-95, (63.5%
identity in 600 aa overlap). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3533c"
/db_xref="EnsemblGenomes-Tr:CCP46355"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHX7"
/protein_id="CCP46355.1"
/translation="MNYAVLPPELNSLRMFTGAGSAPMLAAAVAWDGLAAELGSAASS
FGSVTSDLASQAWQGPAAAAMAAAAAPYAGWLSAAAARAAGAAAQAKAVASAFEAARA
ATVHPLLVAANRNAFAQLVMSNWFGLNAPLIAAVEGAYEQMWAADVAAMVGYHSGASA
AAEQLVPFQQALQQLPNLGIGNIGNANLGGGNTGDLNTGNGNIGNTNLGSGNRGDANL
GSGNIGNSNVGGGNVGNGNFGSGNGRAGLPGSGNVGNGNLGNSNLGSGNTGNSNVGFG
NTGNNNVGTGNAGSGNIGAGNTGSSNWGFGNNGIGNIGFGNTGNGNIGFGLTGNNQVG
IGGLNSGSGNIGLFNSGTNNVGFFNSGNGNLGIGNSSDANVGIGNSGATVGPFVAGHN
TGFGNSGSLNTGMGNAGGVNTGFGNGGAINLGFGNSGQLNAGSFNAGSINTGNFNSGQ
GNTGDFNAGVRNTGWSNSGLTNTGAFNAGSLNTGFGAVGTGSGPNSGFGNAGTNNSGF
FNTGVGSSGFQNGGSNNSGLQNAVGTVIAAGFGNTGAQTVGIANSGVLNSGFFNSGVH
NSGGFNSENQRSGFGN"
gene complement(3972552..3973592)
/gene="hsaF"
/locus_tag="Rv3534c"
CDS complement(3972552..3973592)
/codon_start=1
/transl_table=11
/gene="hsaF"
/locus_tag="Rv3534c"
/product="Probable 4-hydroxy-2-oxovalerate aldolase (HOA)"
/note="Rv3534c, (MTCY03C7.22), len: 346 aa. Probable
hsaF,4-hydroxy-2-oxovalerate aldolase, highly similar to
others e.g. P51015|BPHI_PSESP from Pseudomonas sp. strain
LB400 (346 aa), FASTA scores: opt: 1150, E(): 2.3e-61,
(51.35% identity in 331 aa overlap); Q52040|BPHX3 from
Pseudomonas pseudoalcaligenes (346 aa), FASTA scores: opt:
1147, E(): 3.5e-61, (51.35% identity in 331 aa overlap);
P51017|NAHM_PSEPU from Pseudomonas putida (346 aa), FASTA
scores: opt: 1145, E(): 4.7e-61, (50.9% identity in 330 aa
overlap) (see citation below);
P51020|MHPE_ECOLI|MHPF|B0352 from Escherichia coli strain
K12 (337 aa), FASTA scores: opt: 1133, E(): 2.4e-60,
(52.0% identity in 327 aa overlap); O24833|ATDG from
Acinetobacter sp (340 aa), FASTA scores: opt: 1132, E():
2.7e-60, (50.45% identity in 331 aa overlap); etc. Note
that also highly similar to Q9ZI56|NAHM
2-oxo-4-hydroxypentanoate aldolase from Pseudomonas
stutzeri (Pseudomonas perfectomarina) (346 aa) FASTA
scores: opt: 1168, E(): 2e-62, (51.05% identity in 331 aa
overlap) (see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv3534c"
/db_xref="EnsemblGenomes-Tr:CCP46356"
/db_xref="GOA:P9WMK5"
/db_xref="InterPro:IPR000891"
/db_xref="InterPro:IPR012425"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR017629"
/db_xref="InterPro:IPR035685"
/db_xref="PDB:4JN6"
/db_xref="UniProtKB/Swiss-Prot:P9WMK5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46356.1"
/translation="MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPV
IEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARD
NGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAG
CQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGA
KQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLL
DRNALIMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEI
KRELDSGAAVTH"
gene complement(3973589..3974500)
/gene="hsaG"
/locus_tag="Rv3535c"
CDS complement(3973589..3974500)
/codon_start=1
/transl_table=11
/gene="hsaG"
/locus_tag="Rv3535c"
/product="Probable acetaldehyde dehydrogenase
(acetaldehyde dehydrogenase [acetylating])"
/note="Rv3535c, (MTCY03C7.21), len: 303 aa. Probable
hsaG,acetaldehyde dehydrogenase, highly similar to many
e.g. BAB62056|TDNI from Pseudomonas putida (302 aa), FASTA
scores: opt: 1159, E(): 1.5e-62, (60.45% identity in 301
aa overlap); Q9ZI57|NAHO from Pseudomonas stutzeri
(Pseudomonas perfectomarina) (307 aa) FASTA scores: opt:
1151, E(): 4.6e-62, (59.55% identity in 299 aa overlap);
Q9F9I4|CDOI from Comamonas sp. JS765 (302 aa) FASTA
scores: opt: 1136, E(): 3.6e-61, (60.15% identity in 301
aa overlap); Q51962|NAHO from Pseudomonas putida (307
aa),FASTA scores: opt: 1133, E(): 5.6e-61, (58.55%
identity in 299 aa overlap) (see citation below);
P77580|MHPF_ECOLI|MHPF|MHPE|B0351 from Escherichia coli
strain K12 (316 aa), FASTA scores: opt: 1040, E():
2.2e-55,(56.85% identity in 306 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3535c"
/db_xref="EnsemblGenomes-Tr:CCP46357"
/db_xref="GOA:P9WQH3"
/db_xref="InterPro:IPR000534"
/db_xref="InterPro:IPR003361"
/db_xref="InterPro:IPR015426"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:4JN6"
/db_xref="UniProtKB/Swiss-Prot:P9WQH3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46357.1"
/translation="MPSKAKVAIVGSGNISTDLLYKLLRSEWLEPRWMVGIDPESDGL
ARAAKLGLETTHEGVDWLLAQPDKPDLVFEATSAYVHRDAAPKYAEAGIRAIDLTPAA
VGPAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVSRIVEVPYAEIVASVASVSAG
PGTRANIDEFTKTTARGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPTDADREA
IAASIHDVVKEVQTYVPGYRLLNEPQFDEPSINSGGQALVTTFVEVEGAGDYLPPYAG
NLDIMTAAATKVGEEIAKETLVVGGAR"
gene complement(3974511..3975296)
/gene="hsaE"
/locus_tag="Rv3536c"
CDS complement(3974511..3975296)
/codon_start=1
/transl_table=11
/gene="hsaE"
/locus_tag="Rv3536c"
/product="Probable hydratase"
/note="Rv3536c, (MTCY03C7.20), len: 261 aa. Probable
hsaE,hydratase, 2-oxo-hepta-3-ene-1,7-dioate hydratase or
2-keto-4-pentenoate hydratase. Indeed, highly similar to
many 2-oxo-hepta-3-ene-1,7-dioate hydratases e.g.
Q9CKS2|HPAH|PM1534 from Pasteurella multocida (267 aa)
FASTA scores: opt: 743, E(): 1.5e-39, (45.5% identity in
266 aa overlap) Q9RZ31|DRA0122 from Deinococcus
radiodurans (268 aa), FASTA scores: opt: 709, E(): 2e-37,
(45.5% identity in 266 aa overlap); Q9HWQ4|HPCG|PA4127
from Pseudomonas aeruginosa (267 aa), FASTA scores: opt:
703,E(): 4.8e-37, (45.1% identity in 266 aa overlap);
Q46982|HPAH|HPCG from Escherichia colis strain ATCC 11105
(267 aa), FASTA scores: opt: 679, E(): 1.6e-35, (41.35%
identity in 266 aa overlap); etc. But also highly similar
to many 2-keto-4-pentenoate hydratases
(2-hydroxypentadienoic acidhydratases) e.g. Q9LAF7|PHED
from Bacillus thermoglucosidasius (258 aa), FASTA scores:
opt: 698, E(): 9.7e-37, (42.45% identity in 252 aa
overlap); Q52442|BPHH from Pseudomonas sp (260 aa) FASTA
scores: opt: 675, E(): 2.7e-35, (41.4% identity in 251 aa
overlap); P77608|MHPD_ECOLI|B0350 from Escherichia coli
strain K12 (269 aa), FASTA scores: opt: 674, E():
3.2e-35,(42.75% identity in 255 aa overlap); Q52038|BPHX1
from Pseudomonas pseudoalcaligenes (260 aa), FASTA scores:
opt: 663, E(): 1.5e-34, (40.6% identity in 251 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3536c"
/db_xref="EnsemblGenomes-Tr:CCP46358"
/db_xref="GOA:I6XHH5"
/db_xref="InterPro:IPR011234"
/db_xref="InterPro:IPR036663"
/db_xref="UniProtKB/TrEMBL:I6XHH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46358.1"
/translation="MLRDATRDELAADLAQAERSRDPIGQLTAAHPEIDVVDAYEIQL
INIRQRVAEGARVVGHKVGLSSPIMQQMMGVDEPDYGHLLDDMQVFEDTPVQASRYLS
PRVEVEVGFILAADLPGAGCTEDDVLAATEALVPAIELIDTRIKDWQIKICDTIADNA
SAAGFVLGAARVPPADLDVRAIDAKLTRNGEVVAEGRSDAVLGNPATAVAWLAGKVES
FGVRLRKGDIVLPGSCTFAVEARAGDEFVADFTGLGLVRLSFE"
gene 3975369..3977060
/gene="kstD"
/locus_tag="Rv3537"
CDS 3975369..3977060
/codon_start=1
/transl_table=11
/gene="kstD"
/locus_tag="Rv3537"
/product="Probable dehydrogenase"
/note="Rv3537, (MTCY03C7.19c), len: 563 aa. Probable
kstD,dehydrogenase, similar to many dehydrogenases or
hypothetical proteins e.g. Q9I1M6|PA2243 hypothetical
protein from Pseudomonas aeruginosa (577 aa), FASTA
scores: opt: 984, E(): 1.2e-48, (34.75% identity in 573 aa
overlap); Q06401|3O1D_COMTE 3-oxosteroid 1-dehydrogenase
from Comamonas testosteroni (Pseudomonas testosteroni)
(573 aa), FASTA scores: opt: 955, E(): 5.5e-47, (33.05%
identity in 590 aa overlap); Q9RA02|KSTD1 3-ketosteroid
dehydrogenase from Rhodococcus erythropolis (510 aa),
FASTA scores: opt: 631, E(): 1.4e-28, (39.15% identity in
557 aa overlap); P77815|KSDD 3-ketosteroid-1-dehydrogenase
from Nocardioides simplex (Arthrobacter simplex) (515 aa),
FASTA scores: opt: 469, E(): 2.4e-19, (35.45% identity in
564 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3537"
/db_xref="EnsemblGenomes-Tr:CCP46359"
/db_xref="GOA:P71864"
/db_xref="InterPro:IPR003953"
/db_xref="InterPro:IPR027477"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P71864"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46359.1"
/translation="MTVQEFDVVVVGSGAAGMVAALVAAHRGLSTVVVEKAPHYGGST
ARSGGGVWIPNNEVLKRRGVRDTPEAARTYLHGIVGEIVEPERIDAYLDRGPEMLSFV
LKHTPLKMCWVPGYSDYYPEAPGGRPGGRSIEPKPFNARKLGADMAGLEPAYGKVPLN
VVVMQQDYVRLNQLKRHPRGVLRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQR
AGVPVELNTAFTDLFVENGVVSGVYVRDSHEAESAEPQLIRARRGVILACGGFEHNEQ
MRIKYQRAPITTEWTVGASANTGDGILAAEKLGAALDLMDDAWWGPTVPLVGKPWFAL
SERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEHGQGPGPGENIPAWLVFDQRYR
DRYIFAGLQPGQRIPSRWLDSGVIVQADTLAELAGKAGLPADELTATVQRFNAFARSG
VDEDYHRGESAYDRYYGDPSNKPNPNLGEVGHPPYYGAKMVPGDLGTKGGIRTDVNGR
ALRDDGSIIDGLYAAGNVSAPVMGHTYPGPGGTIGPAMTFGYLAALHIADQAGKR"
gene 3977062..3977922
/gene_synonym="hsd4B"
/locus_tag="Rv3538"
CDS 3977062..3977922
/codon_start=1
/transl_table=11
/gene_synonym="hsd4B"
/locus_tag="Rv3538"
/product="Probable dehydrogenase. Possible 2-enoyl
acyl-CoA hydratase."
/note="Rv3538, (MTCY03C7.18c), len: 286 aa. Probable
double hotdog R-specific hydratase, substrate unknown,
shows structural similarity to six others in Mycobacterium
tuberculosis (see Castell et al (2005) below) especially
Rv3389. Probable dehydrogenase, similar to
Q9L009|SCC30.12c putative dehydrogenase from Streptomyces
coelicolor (333 aa), FASTA scores: opt: 842, E(): 3.6e-44,
(48.4% identity in 285 aa overlap); and similar to
C-terminal part of other (principally estradiol 17
beta-dehydrogenases/17-beta-hydroxysteroid dehydrogenases)
e.g. P70540 peroxisomal multifunctional enzyme type II
(SDR family) from Rattus norvegicus (Rat) (735 aa) FASTA
scores: opt: 622, E(): 1.9e-30, (37.45% identity in 283 aa
overlap); or P70523|MPF-2 multifunctional protein 2 (SDR
family) (beta-oxidation protein displaying 2-enoyl-CoA
hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity)
from Rattus norvegicus (Rat) (734 aa), FASTA scores: opt:
616, E(): 4.3e-30, (37.1% identity in 283 aa overlap);
P51659|DHB4_HUMAN|HSD17B4|EDH17B4 estradiol 17
beta-dehydrogenase from Homo sapiens (Human) (736
aa),FASTA scores: opt: 614, E(): 5.7e-30, (35.9% identity
in 284 aa overlap); P97852|DHB4_RAT|HSD17B4|EDH17B4
estradiol 17 beta-dehydrogenase from Rattus norvegicus
(Rat) (735 aa) FASTA scores: opt: 613, E(): 6.6e-30,
(37.1% identity in 283 aa overlap); Q9DBM3|HSD17B4
estradiol 17 beta-dehydrogenase from Mus musculus (Mouse)
(735 aa) FASTA scores: opt: 611, E(): 8.7e-30, (36.5%
identity in 285 aa overlap); etc. Also similar to
Q11198|Rv3389c|MTV004.47c hypothetical 30.3 KDA protein
from Mycobacterium tuberculosis (290 aa), FASTA scores:
opt: 609, E(): 5.3e-30, (39.65% identity in 285 aa
overlap). Note that previously known as ufaA2."
/db_xref="EnsemblGenomes-Gn:Rv3538"
/db_xref="EnsemblGenomes-Tr:CCP46360"
/db_xref="GOA:Q6MWW2"
/db_xref="InterPro:IPR002539"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR039569"
/db_xref="UniProtKB/TrEMBL:Q6MWW2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46360.1"
/translation="MPIDLDVALGAQLPPVEFSWTSTDVQLYQLGLGAGSDPMNPREL
SYLADDTPQVLPTFGNVAATFHLTTPPTVQFPGIDIELSKVLHASERVEVPAPLPPSG
SARAVTRFTDIWDKGKAAVICSETTATTPDGLLLWTQKRSIYARGEGGFGGKRGPSGS
DVAPERAPDLQVAMPILPQQALLYRLCGDRNPLHSDPEFAAAAGFPRPILHGLCTYGM
TCKAIVDALLDSDATAVAGYGARFAGVAYPGETLTVNVWKDGRRLVASVVAPTRDNAV
VLSGVELVPA"
gene 3978059..3979498
/gene="PPE63"
/locus_tag="Rv3539"
CDS 3978059..3979498
/codon_start=1
/transl_table=11
/gene="PPE63"
/locus_tag="Rv3539"
/product="PPE family protein PPE63"
/note="Rv3539, (MTCY03C7.17c), len: 479 aa. PPE63, Member
of the Mycobacterium tuberculosis PPE protein
family,similar to many e.g. O53949|Rv1800|MTV049.22 (655
aa),FASTA scores: opt: 914, E(): 7.3e-47, (37.55% identity
in 490 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3539"
/db_xref="EnsemblGenomes-Tr:CCP46361"
/db_xref="GOA:P9WHX5"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHX5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46361.1"
/translation="MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAA
SFESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEAAF
AATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVAS
AVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPF
IGRLLAARYAELNTAIGTNWFPGTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQML
HNEILAATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSALTFVELAGPERGLA
QTYLPVGTTIPIAGYTVGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAA
YFHDLTAYAAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLLPLKQIGVPDWIVGGLN
NVLKPLVDAGYSQYAPTAGPYFSHGNLVW"
gene complement(3979499..3980659)
/gene="ltp2"
/locus_tag="Rv3540c"
CDS complement(3979499..3980659)
/codon_start=1
/transl_table=11
/gene="ltp2"
/locus_tag="Rv3540c"
/product="Probable lipid transfer protein or keto acyl-CoA
thiolase Ltp2"
/note="Rv3540c, (MTCY03C7.16), len: 386 aa. Probable
ltp2,lipid-transfer protein or keto acyl-CoA thiolase,
similar to several e.g. Q9X4X2|DITF DITF protein
(hypothetical protein, similar to non-specific
lipid-transfer protein and 3-ketoacyl-CoA thiolase) from
Pseudomonas abietaniphila (397 aa), FASTA scores: opt:
665, E(): 5.3e-34, (33.4% identity in 392 aa overlap);
O30255|AF2416 3-ketoacyl-CoA thiolase (ACAB-12) from
Archaeoglobus fulgidus (384 aa),FASTA scores: opt: 496,
E(): 1.6e-23, (30.35% identity in 389 aa overlap);
O28978|AF1291 3-ketoacyl-CoA thiolase (ACAB-11) from
Archaeoglobus fulgidus (392 aa), FASTA scores: opt: 494,
E(): 2.2e-23, (30.6% identity in 379 aa overlap);
O26884|MTH793 lipid-transfer protein (sterol or
nonspecific) from Methanobacterium thermoautotrophicum
(383 aa), FASTA scores: opt: 487, E(): 5.9e-23, (30.4%
identity in 388 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3540c"
/db_xref="EnsemblGenomes-Tr:CCP46362"
/db_xref="GOA:I6Y3T7"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="UniProtKB/TrEMBL:I6Y3T7"
/protein_id="CCP46362.1"
/translation="MLSGQAAIVGIGATDFSKNSGRSELRLAAEAVLDALADAGLSPT
DVDGLTTFTMDTNTEIAVARAAGIGELTFFSKIHYGGGAACATVQHAAMAVATGVADV
VVAYRAFNERSGMRFGQVQTRLTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHL
SGATSRDFGAVSVADRKHAANNPKAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDG
AVAIVVTSAARARDLKQRPVVIEAAAQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLW
AQSGLTPADVQTAVLYDHFTPFTLIQLEELGFCGKGEAKDFIADGAIEVGGRLPINTH
GGQLGEAYIHGMNGIAEGVRQLRGTSVNPVAGVEHVLVTAGTGVPTSGLILG"
gene complement(3980659..3981048)
/locus_tag="Rv3541c"
CDS complement(3980659..3981048)
/codon_start=1
/transl_table=11
/locus_tag="Rv3541c"
/product="Conserved protein"
/note="Rv3541c, (MTCY03C7.15), len: 129 aa. Conserved
protein, showing some similarity to Q9CBJ7|ML1909
hypothetical protein from Mycobacterium leprae (142 aa)
FASTA scores: opt: 110, E(): 1.2, (27.95% identity in 118
aa overlap); and other (see also blastp results) e.g.
Q9L0M3|SCD82.08 hypothetical 15.2 KDA protein from
Streptomyces coelicolor (142 aa), FASTA scores: opt:
127,E(): 0.086, (27.65% identity in 123 aa overlap).
Contains PS00075 Dihydrofolate reductase signature."
/db_xref="EnsemblGenomes-Gn:Rv3541c"
/db_xref="EnsemblGenomes-Tr:CCP46363"
/db_xref="InterPro:IPR029069"
/db_xref="UniProtKB/TrEMBL:I6XHI0"
/inference="protein motif:PROSITE:PS00075"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46363.1"
/translation="MTVVGAVLPELKLYGDPTFIVSTALATRDFQDVHHDRDKAVAQG
SKDIFVNILTDTGLVQRYVTDWAGPSALIKSIGLRLGVPWYAYDTVTFSGEVTAVNDG
LITVKVVGRNTLGDHVTATVELSMRDS"
gene complement(3981045..3981980)
/locus_tag="Rv3542c"
CDS complement(3981045..3981980)
/codon_start=1
/transl_table=11
/locus_tag="Rv3542c"
/product="Conserved hypothetical protein"
/note="Rv3542c, (MTCY03C7.14), len: 311 aa. Hypothetical
protein, showing some similarity to other e.g.
Q58947|MJ1552 from Methanococcus jannaschii (141 aa) FASTA
scores: opt: 177, E(): 0.00065, (46.65% identity in 60 aa
overlap); BAB59276|TVG0142586 from Thermoplasma volcanium
(135 aa), FASTA scores: opt: 175, E(): 0.00083, (35.65%
identity in 87 aa overlap); Q9HI85|TA1457 from
Thermoplasma acidophilum (135 aa), FASTA scores: opt: 162,
E(): 0.0052,(31.8% identity in 107 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3542c"
/db_xref="EnsemblGenomes-Tr:CCP46364"
/db_xref="InterPro:IPR002878"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR029069"
/db_xref="InterPro:IPR039375"
/db_xref="InterPro:IPR039569"
/db_xref="UniProtKB/TrEMBL:I6YGF8"
/protein_id="CCP46364.1"
/translation="MTGVSDIQEAVAQIKAAGPSKPRLARDPVNQPMINNWVEAIGDR
NPIYVDDAAARAAGHPGIVAPPAMIQVWTMMGLGGVRPKDDPLGPIIKLFDDAGYIGV
VATNCEQTYHRYLLPGEQVSISAELGDVVGPKQTALGEGWFINQHIVWQVGDEDVAEM
NWRILKFKPAGSPSSVPDDLDPDAMMRPSSSRDTAFFWDGVKAHELRIQRLADGSLRH
PPVPAVWQDKSVPINYVVSSGRGTVFSFVVHHAPKVPGRTVPFVIALVELEEGVRMLG
ELRGADPARVAIGMPVRATYIDFPDWSLYAWEPDE"
gene complement(3981977..3983140)
/gene="fadE29"
/locus_tag="Rv3543c"
CDS complement(3981977..3983140)
/codon_start=1
/transl_table=11
/gene="fadE29"
/locus_tag="Rv3543c"
/product="Probable acyl-CoA dehydrogenase FadE29"
/note="Rv3543c, (MTCY03C7.13), len: 387 aa. Probable
fadE29, acyl-CoA dehydrogenase, similar to many e.g.
Q9A8P3|CC1310 from Caulobacter crescentus (404 aa), FASTA
scores: opt: 624, E(): 9.4e-32, (32.75% identity in 400 aa
overlap); Q9I4V2|PA1022 from Pseudomonas aeruginosa (381
aa), FASTA scores: opt: 550, E(): 3.9e-27, (33.7% identity
in 350 aa overlap); O28976|AF1293 from Archaeoglobus
fulgidus (384 aa), FASTA scores: opt: 529, E():
8.1e-26,(30.0% identity in 393 aa overlap); etc. Also
similar to other from Mycobacterium tuberculosis e.g.
O53549|FADE26|Rv3504|MTV023.11 (400 aa), FASTA scores:
opt: 1031, E(): 2.8e-57, (46.0% identity in 402 aa
overlap). Could belong to the acyl-CoA dehydrogenases
family."
/db_xref="EnsemblGenomes-Gn:Rv3543c"
/db_xref="EnsemblGenomes-Tr:CCP46365"
/db_xref="GOA:P71858"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/Swiss-Prot:P71858"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46365.1"
/translation="MFIDLTPEQRQLQAEIRQYFSNLISPDERTEMEKDRHGPAYRAV
IRRMGRDGRLGVGWPKEFGGLGFGPIEQQIFVNEAHRADVPLPAVTLQTVGPTLQAHG
SELQKKKFLPAILAGEAHFAIGYTEPEAGTDLASLRTTAVRDGDHYIVNGQKVFTTGA
HDADYIWLACRTDPNAAKHKGISILIVDTKDPGYSWTPIILADGAHHTNATYYNDVRV
PVDMLVGKENDGWRLITTQLNNERVMLGPAGRFASIYDRVHAWASVPGGNGVTPIDHD
DVKRALGEIRAIWRINELLNWQVASAGEDINMADAAATKVFGTERVQRAGRLAEEIVG
KYGNPAEPDTAELLRWLDAQTKRNLVITFGGGVNEVMREMIAASGLKVPRVPR"
gene complement(3983125..3984144)
/gene="fadE28"
/locus_tag="Rv3544c"
CDS complement(3983125..3984144)
/codon_start=1
/transl_table=11
/gene="fadE28"
/locus_tag="Rv3544c"
/product="Probable acyl-CoA dehydrogenase FadE28"
/note="Rv3544c, (MTCY03C7.12), len: 339 aa. Probable
fadE28, acyl-CoA dehydrogenase, similar to many e.g.
Q9RJX3|SCF37.28c from Streptomyces coelicolor (362
aa),FASTA scores: opt: 334, E(): 5.1e-13, (27.65% identity
in 329 aa overlap); Q9A5G8|CC2479 from Caulobacter
crescentus (344 aa), FASTA scores: opt: 278, E(): 1.2e-09,
(26.95% identity in 319 aa overlap); O29813|AF0436 from
Archaeoglobus fulgidus (382 aa) FASTA scores: opt:
205,E(): 3.5e-05, (24.75% identity in 384 aa overlap);
etc. Also similar to other from Mycobacterium tuberculosis
e.g. O53550|FADE27|Rv3505|MTV023.12 (373 aa) FASTA scores:
opt: 497, E(): 7e-23, (30.3% identity in 343 aa overlap);
and to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34
probable acyl-CoA dehydrogenase from Mycobacterium leprae
(389 aa) FASTA scores: opt: 165, E(): 0.0012, (25.2%
identity in 345 aa overlap). Could belong to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3544c"
/db_xref="EnsemblGenomes-Tr:CCP46366"
/db_xref="GOA:P71857"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/Swiss-Prot:P71857"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46366.1"
/translation="MDFDPTAEQQAVADVVTSVLERDISWEALVCGGVTALPVPERLG
GDGVGLFEVGALLTEVGRHGAVTPALATLGLGVVPLLELASAEQQDRFLAGVAKGGVL
TAALNEPGAALPDRPATSFVGGRLSGTKVGVGYAEQADWMLVTADNAVVVVSPTADGV
RMVRTPTSNGSDEYVMTMDGVAVADCDILADVAAHRVNQLALAVMGAYADGLVAGALR
LTADYVANRKQFGKPLSTFQTVAAQLAEVYIASRTIDLVAKSVIWRLAEDLDAGDDLG
VLGYWVTSQAPPAMQICHHLHGGMGMDVTYPMHRYYSTIKDLTRLLGGPSHRLELLGA
RCSLT"
gene complement(3984144..3985445)
/gene="cyp125"
/locus_tag="Rv3545c"
CDS complement(3984144..3985445)
/codon_start=1
/transl_table=11
/gene="cyp125"
/locus_tag="Rv3545c"
/product="Probable cytochrome P450 125 Cyp125"
/note="Rv3545c, (MT3649, MTCY03C7.11), len: 433 aa.
Probable cyp125, cytochrome P-450, similar to others e.g.
Q59723|LINC|CYP111 from Pseudomonas incognita (406
aa),FASTA scores: opt: 831, E(): 8e-45, (34.75% identity
in 406 aa overlap); Q9X8Q3|CYP107P1|SCH10.14c from
Streptomyces coelicolor (411 aa), FASTA scores: opt: 694,
E(): 3.3e-36,(32.35% identity in 417 aa overlap);
Q9L465|CYP162A1|NIKQ from Streptomyces tendae (396 aa)
FASTA scores: opt: 664,E(): 2.5e-34, (34.15% identity in
413 aa overlap); O08469|CPXY_BACSU|CYPA|CYP107J1 from
Bacillus subtilis (410 aa), FASTA scores: opt: 579, E():
5.6e-29, (30.05% identity in 366 aa overlap); etc. Also
similar to other from Mycobacterium tuberculosis e.g.
Q50696|CYP124|Rv2266|MT2328|MTCY339.44c (428 aa) FASTA
scores: opt: 1040, E(): 6.1e-58, (40.75% identity in 432
aa overlap). Belongs to the cytochrome P450 family."
/db_xref="EnsemblGenomes-Gn:Rv3545c"
/db_xref="EnsemblGenomes-Tr:CCP46367"
/db_xref="GOA:P9WPP1"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002397"
/db_xref="InterPro:IPR036396"
/db_xref="PDB:2X5L"
/db_xref="PDB:2X5W"
/db_xref="PDB:2XC3"
/db_xref="PDB:2XN8"
/db_xref="PDB:3IVY"
/db_xref="PDB:3IW0"
/db_xref="PDB:3IW1"
/db_xref="PDB:3IW2"
/db_xref="UniProtKB/Swiss-Prot:P9WPP1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46367.1"
/translation="MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFA
ELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKN
DIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAA
AGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSA
ELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNS
ITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKG
QRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFN
AVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH"
gene 3985557..3986732
/gene="fadA5"
/locus_tag="Rv3546"
CDS 3985557..3986732
/codon_start=1
/transl_table=11
/gene="fadA5"
/locus_tag="Rv3546"
/product="Probable acetyl-CoA acetyltransferase FadA5
(acetoacetyl-CoA thiolase)"
/note="Rv3546, (MTCY03C7.10c), len: 391 aa. Probable
fadA5,acetyl-CoA acetyltransferase, similar to many e.g.
Q9AA29|CC0779 from Caulobacter crescentus (390 aa), FASTA
scores: opt: 999, E(): 7.1e-54, (43.5% identity in 400 aa
overlap); Q9K783|BH3487 from Bacillus halodurans (393
aa),FASTA scores: opt: 843, E(): 2.6e-44, (37.45% identity
in 398 aa overlap); Q9RRK9|DR2480 from Deinococcus
radiodurans (399 aa), FASTA scores: opt: 826, E():
2.8e-43, (38.15% identity in 396 aa overlap);
P45369|THIL_CHRVI|PHBA from Chromatium vinosum (394 aa)
FASTA scores: opt: 790, E(): 4.5e-41, (39.4% identity in
401 aa overlap); etc. Contains PS00737 Thiolases signature
2. Belongs to the thiolase family."
/db_xref="EnsemblGenomes-Gn:Rv3546"
/db_xref="EnsemblGenomes-Tr:CCP46368"
/db_xref="GOA:I6XHI4"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020613"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="PDB:4UBT"
/db_xref="PDB:4UBU"
/db_xref="PDB:4UBV"
/db_xref="PDB:4UBW"
/db_xref="PDB:5ONC"
/db_xref="UniProtKB/Swiss-Prot:I6XHI4"
/inference="protein motif:PROSITE:PS00737"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46368.1"
/translation="MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQ
SGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGLPEHVGATTVDCQCGSGQQANHL
IAGLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAK
RRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQ
GLRETTMAGLGELKPVLEGGIHTAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVA
QALVGAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFASVVLSWARVHEPDMD
RVNVNGGAIALGHPVGCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI"
gene 3986844..3987299
/gene="ddn"
/locus_tag="Rv3547"
CDS 3986844..3987299
/codon_start=1
/transl_table=11
/gene="ddn"
/locus_tag="Rv3547"
/product="Deazaflavin-dependent nitroreductase Ddn"
/note="Rv3547, (MTCY03C7.09c), len: 151 aa.
Ddn,deazaflavin-dependent nitroreducatse (See Singh et
al.,2008). Similar to hypothetical proteins e.g.
O85698|3SCF60.07 from Streptomyces lividans and
Streptomyces coelicolor (149 aa), FASTA scores: opt:
353,E(): 6.3e-17, (42.55% identity in 134 aa overlap);
Q9WX21|SCE68.11 from Streptomyces coelicolor (305 aa)
FASTA scores: opt: 290, E(): 2.1e-12, (38.5% identity in
122 aa overlap) (similarity in N-terminus for this
protein); BAB52932|Q988L5|MLL6688 from Rhizobium loti
(Mesorhizobium loti) (148 aa), FASTA scores: opt: 105,
E(): 3, (26.75% identity in 86 aa overlap). Also similar
to mycobacterial hypothetical proteins e.g. Q9ZH81 from
Mycobacterium paratuberculosis (144 aa), FASTA scores:
opt: 366, E(): 8.2e-18, (43.9% identity in 123 aa
overlap); and Q10772|YF58_MYCTU|Rv1558|MT1609|MTCY48.07c
from Mycobacterium tuberculosis (148 aa), FASTA scores:
opt: 330, E(): 2.2e-15, (39.75% identity in 151 aa
overlap); etc. Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3547"
/db_xref="EnsemblGenomes-Tr:CCP46369"
/db_xref="GOA:P9WP15"
/db_xref="InterPro:IPR004378"
/db_xref="InterPro:IPR012349"
/db_xref="PDB:3R5L"
/db_xref="PDB:3R5P"
/db_xref="PDB:3R5R"
/db_xref="PDB:3R5W"
/db_xref="UniProtKB/Swiss-Prot:P9WP15"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46369.1"
/translation="MPKSPPRFLNSPLSDFFIKWMSRINTWMYRRNDGEGLGGTFQKI
PVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQI
KKEVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCEP"
gene complement(3987382..3988296)
/locus_tag="Rv3548c"
CDS complement(3987382..3988296)
/codon_start=1
/transl_table=11
/locus_tag="Rv3548c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv3548c, (MTCY03C7.08), len: 304 aa. Probable
short-chain dehydrogenase/reductase, highly similar to
various dehydrogenases/reductases (generally belonging to
the SDR family) e.g. Q9I4V1|PA1023 from Pseudomonas
aeruginosa (305 aa), FASTA scores: opt: 446, E():
1.7e-17,(43.75% identity in 256 aa overlap); Q9A6K0|CC2093
from Caulobacter crescentus (301 aa) FASTA scores: opt:
437,E(): 5.3e-17, (42.8% identity in 257 aa overlap);
Q9HYH8|PA3427 from Pseudomonas aeruginosa (303 aa), FASTA
scores: opt: 399, E(): 6.5e-15, (45.5% identity in 257 aa
overlap); Q9VXJ0|CG3415 from Drosophila melanogaster
(Fruit fly) (598 aa), FASTA scores: opt: 402, E():
7.5e-15, (40.7% identity in 285 aa overlap); etc. Also
highly similar to O53547|Rv3502c|MTV023.09c putative
short-chain type dehydrogenase/reductase from (317 aa)
FASTA scores: opt: 739, E(): 1.6e-33, (45.15% identity in
310 aa overlap); and other proteins from Mycobacterium
tuberculosis. Contains PS00061 Short-chain alcohol
dehydrogenase family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv3548c"
/db_xref="EnsemblGenomes-Tr:CCP46370"
/db_xref="GOA:P71853"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P71853"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46370.1"
/translation="MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDG
SPASGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYGGVDVLVNNAG
IVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLSKAGKAPKDIDARIINTS
SGAGLQGSVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAARTRMTETVFAEM
MAKPQEGFDAMAPENVSPLVVWLGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKG
VKWDPAELGPVVSDLLAKSRPPVPVYGA"
gene complement(3988319..3989098)
/locus_tag="Rv3549c"
CDS complement(3988319..3989098)
/codon_start=1
/transl_table=11
/locus_tag="Rv3549c"
/product="Probable short-chain type
dehydrogenase/reductase"
/note="Rv3549c, (MTCY03C7.07), len: 259 aa. Probable
short-chain dehydrogenase/reductase, similar to various
dehydrogenases/reductases (generally belong to the SDR
family) e.g. Q9UKU3 from Homo sapiens (Human) (270
aa),FASTA scores: opt: 451, E(): 4.8e-21, (38.05% identity
in 247 aa overlap); Q9S274|SCI28.09c from Streptomyces
coelicolor (234 aa), FASTA scores: opt: 439, E():
2.4e-20,(36.8% identity in 231 aa overlap); Q9PFI6|XF0671
from Xylella fastidiosa (247 aa), FASTA scores: opt: 437,
E(): 3.4e-20, (37.7% identity in 252 aa overlap); etc.
Also highly similar to O33308|FABG5|Rv2766c|MTV002.31c
alcohol dehydrogenase (SDR family) from Mycobacterium
tuberculosis (260 aa), FASTA scores: opt: 504, E():
2.3e-24, (38.5% identity in 244 aa overlap). Contains
PS00061 Short-chain alcohol dehydrogenase family
signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv3549c"
/db_xref="EnsemblGenomes-Tr:CCP46371"
/db_xref="GOA:I6YCE1"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6YCE1"
/inference="protein motif:PROSITE:PS00061"
/protein_id="CCP46371.1"
/translation="MTLAEAADAINFGLAGRVVLVTGGVRGVGAGISSVFAEQGATVI
TCARRAVDGQPYEFHRCDIRDEDSVKRLVGEIGERHGRLDMLVNNAGGSPYALAAEAT
HNFHRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNICSVSGRRPTPGTAAYGAAKA
GLENLTTTLAVEWAPKVRVNAVVVGMVETERSELFYGDAESIARVAATVPLGRLARPA
DIGWAAAFLASDAASYISGATLEVHGGGEPPPYLGASSANK"
gene 3989153..3989896
/gene="echA20"
/locus_tag="Rv3550"
CDS 3989153..3989896
/codon_start=1
/transl_table=11
/gene="echA20"
/locus_tag="Rv3550"
/product="Probable enoyl-CoA hydratase EchA20 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv3550, (MTCY03C7.06c), len: 247 aa. Probable
echA20, enoyl-CoA hydratase, similar to others e.g.
Q9A7B0|CC1814 from Caulobacter crescentus (275 aa), FASTA
scores: opt: 488, E(): 3.5e-24, (36.4% identity in 239 aa
overlap); O84978|PHAA from Pseudomonas putida (293
aa),FASTA scores: opt: 383, E(): 2e-17, (33.85% identity
in 254 aa overlap); BAB48479|Q98LI4|MLL1009 from Rhizobium
loti (Mesorhizobium loti) (258 aa), FASTA scores: opt:
378, E(): 3.8e-17, (21.45% identity in 231 aa overlap);
etc. Could belong to the enoyl-CoA hydratase/isomerase
family."
/db_xref="EnsemblGenomes-Gn:Rv3550"
/db_xref="EnsemblGenomes-Tr:CCP46372"
/db_xref="GOA:I6Y3U6"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:I6Y3U6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46372.1"
/translation="MPITSTTPEPGIVAVTVDYPPVNAIPSKAWFDLADAVTAAGANS
DTRAVILRAEGRGFNAGVDIKEMQRTEGFTALIDANRGCFAAFRAVYECAVPVIAAVN
GFCVGGGIGLVGNSDVIVASEDATFGLPEVERGALGAATHLSRLVPQHLMRRLFFTAA
TVDAATLQHFGSVHEVVSRDQLDEAALRVARDIAAKDTRVIRAAKEALNFIDVQRVNA
SYRMEQGFTFELNLAGVADEHRDAFVKKS"
gene 3989896..3990774
/locus_tag="Rv3551"
CDS 3989896..3990774
/codon_start=1
/transl_table=11
/locus_tag="Rv3551"
/product="Possible CoA-transferase (alpha subunit)"
/note="Rv3551, (MTCY03C7.05c), len: 292 aa. Possible
CoA-transferase, alpha subunit, similar in part to other
CoA-transferases e.g. Q59111|GCTA_ACIFE|GCTA glutaconate
CoA-transferase subunit A (GCT large subunit) from
Acidaminococcus fermentans (319 aa) FASTA scores: opt:
247,E(): 6.3e-09, (27.35% identity in 307 aa overlap);
Q9XD83|PCAI from Streptomyces sp. 2065 (251 aa), FASTA
scores: opt: 222, E(): 2.3e-07, (27.55% identity in 243 aa
overlap); BAB50895|MLL4183 from Rhizobium loti
(Mesorhizobium loti) (285 aa), FASTA scores: opt: 206,
E(): 2.8e-06, (27.4% identity in 281 aa overlap); etc.
Also some similarity with
O06167|SCOA_MYCTU|RVv504c|MT2579|MTCY07A7.10c probable
succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A
from Mycobacterium tuberculosis (248 aa), FASTA scores:
opt: 210, E(): 1.4e-06, (25.5% identity in 247 aa
overlap). Belongs to the glutaconate CoA-transferase
subunit A family. Note that this putative protein may
combine with the putative protein encoded by the
downstream ORF Rv3552 to form a CoA-transferase that
comprises two subunits."
/db_xref="EnsemblGenomes-Gn:Rv3551"
/db_xref="EnsemblGenomes-Tr:CCP46373"
/db_xref="GOA:P9WPW1"
/db_xref="InterPro:IPR004165"
/db_xref="InterPro:IPR037171"
/db_xref="PDB:6CON"
/db_xref="UniProtKB/Swiss-Prot:P9WPW1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46373.1"
/translation="MPDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDV
TDLTVVTYGGPDLGLLCSAGKVKRVYYGFVSLDSPPFYDPWFAHARTSGAIEAREMDE
GMLRCGLQAAAQRLPFLPIRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPAL
RLDAAFAHLNLGDSHGNAAYTGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQ
ALLVNRMMVDAIVEAPGGAHFTTAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSG
TEADYQAAVHNFGASR"
gene 3990771..3991523
/locus_tag="Rv3552"
CDS 3990771..3991523
/codon_start=1
/transl_table=11
/locus_tag="Rv3552"
/product="Possible CoA-transferase (beta subunit)"
/note="Rv3552, (MTCY03C7.03c), len: 250 aa. Possible
CoA-transferase, beta subunit, similar in part to other
CoA-transferases e.g. Q9I6R1|PA0227 from Pseudomonas
aeruginosa (260 aa), FASTA scores: opt: 233, E():
8.6e-08,(24.8% identity in 238 aa overlap);
BAB50894|MLL4181 from Rhizobium loti (Mesorhizobium loti)
(264 aa), FASTA scores: opt: 210, E(): 2.6e-06, (24.15%
identity in 203 aa overlap); and AAK41345|Q97Z51|GCTB from
Sulfolobus solfataricus (245 aa), FASTA scores: opt: 122,
E(): 1.1,(25.5% identity in 243 aa overlap). Possibly
belongs to the glutaconate CoA-transferase subunit B
family. Note that this putative protein may combine with
the putative protein encoded by the upstream ORF Rv3551 to
form a CoA-transferase that comprises two subunits."
/db_xref="EnsemblGenomes-Gn:Rv3552"
/db_xref="EnsemblGenomes-Tr:CCP46374"
/db_xref="GOA:P9WPV9"
/db_xref="InterPro:IPR004165"
/db_xref="InterPro:IPR037171"
/db_xref="PDB:6CON"
/db_xref="UniProtKB/Swiss-Prot:P9WPV9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46374.1"
/translation="MSTRAEVCAVACAELFRDAGEIMISPMTNMASVGARLARLTFAP
DILLTDGEAQLLADTPALGKTGAPNRIEGWMPFGRVFETLAWGRRHVVMGANQVDRYG
NQNISAFGPLQRPTRQMFGVRGSPGNTINHATSYWVGNHCKRVFVEAVDVVSGIGYDK
VDPDNPAFRFVNVYRVVSNLGVFDFGGPDHSMRAVSLHPGVTPGDVRDATSFEVHDLD
AAEQTRLPTDDELHLIRAVIDPKSLRDREIRS"
repeat_region complement(3991568..3991625)
/note="58 bp Mycobacterial Interspersed Repetitive
Unit,Class III."
gene 3991621..3992688
/locus_tag="Rv3553"
CDS 3991621..3992688
/codon_start=1
/transl_table=11
/locus_tag="Rv3553"
/product="Possible oxidoreductase"
/note="Rv3553, (MTCY03C7.02c), len: 355 aa. Possible
oxidoreductase, highly similar (except in C-terminus) to
Q9A327|CC3379 hypothetical protein from Caulobacter
crescentus (321 aa), FASTA scores: opt: 639, E():
4.6e-29,(46.35% identity in 248 aa overlap); and
Q9WZQ7|TM0800 conserved hypothetical protein from
Thermotoga maritima (314 aa), FASTA scores: opt: 622, E():
4.1e-28, (37.95% identity in 340 aa overlap). Also similar
to two trans-2-enoyl-ACP reductases; Q99YD4|FABK|SPY1751
from Streptococcus pyogenes (323 aa), FASTA scores: opt:
604,E(): 4.4e-27, (33.25% identity in 346 aa overlap); and
Q9FBC5|FABK from Streptococcus pneumoniae (324 aa), FASTA
scores: opt: 553, E(): 3.3e-24, (32.1% identity in 346 aa
overlap); and similar with several 2-nitropropane
dioxygenases, e.g. Q9F7P8 from uncultured proteobacterium
EBAC31A08 (322 aa), FASTA scores: opt: 505, E():
1.7e-21,(33.6% identity in 348 aa overlap); Q9FMG0 (alias
AAK44141) from Arabidopsis thaliana (Mouse-ear cress) (333
aa), FASTA scores: opt: 489, E(): 1.4e-20, (33.15%
identity in 341 aa overlap); O28109|AF2173 (NCD2) from
Archaeoglobus fulgidus (274 aa), FASTA scores: opt: 456,
E(): 8.9e-19, (36.3% identity in 237 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3553"
/db_xref="EnsemblGenomes-Tr:CCP46375"
/db_xref="GOA:P71847"
/db_xref="InterPro:IPR004136"
/db_xref="InterPro:IPR013785"
/db_xref="UniProtKB/TrEMBL:P71847"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46375.1"
/translation="MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILA
SATMTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFALAPKQ
QLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHTGPVATTLLLPSVL
DAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQA
GLDGTVVTTRVDGMPHRVLRTELVEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMI
RDGLTMRHGKELTWSQVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKE
LIESIVLDAITHLQTASALVE"
gene 3992685..3994742
/gene="fdxB"
/locus_tag="Rv3554"
CDS 3992685..3994742
/codon_start=1
/transl_table=11
/gene="fdxB"
/locus_tag="Rv3554"
/product="Possible electron transfer protein FdxB"
/note="Rv3554, (MTCY06G11.01, MTCY03C7.01c), len: 685 aa.
Possible fdxB, two-domain protein, with ferredoxin
reductase electron transfer component in C-terminal part
and unknown function in N-terminal part. Indeed,
N-terminal end is similar to O85832 hypothetical 36.1 KDA
protein from Sphingomonas aromaticivorans strain F199
(catabolic plasmid pNL1) (309 aa), FASTA scores: opt: 615,
E(): 2.5e-30,(33.1% identity in 311 aa overlap); and
P73428|SLL1468 hypothetical 36.2 KDA protein from
Synechocystis sp. strain PCC 6803 (312 aa), FASTA scores:
opt: 317, E(): 4.5e-12,(30.2% identity in 268 aa overlap).
And C-terminal end is similar to Q9F9U6|PAAE protein
involved in aerobic phenylacetate metabolism from Azoarcus
evansii (360 aa),FASTA scores: opt: 935, E(): 7e-50,
(43.85% identity in 351 aa overlap);
CAC44653|PAAE|SCBAC17A6.08 putative phenylacetic acid
degradation NADH oxidoreductase from Streptomyces
coelicolor (368 aa), FASTA scores: opt: 93,E(): 9.5e-50,
(41.95% identity in 372 aa overlap); Q9FA57|PACI
ferredoxin from Azoarcus evansii (360 aa),FASTA scores:
opt: 925, E(): 2.9e-49, (43.3% identity in 351 aa
overlap); P76081|PAAE_ECOLI|B1392 probable phenylacetic
acid degradation NADH oxidoreductase from Escherichia coli
strains K12 and W (356 aa), FASTA scores: opt: 910, E():
2.4e-48, (43.05% identity in 353 aa overlap); Q9APJ6|PAAE
electron transfer protein (fragment) from Hyphomicrobium
chloromethanicum (241 aa), FASTA scores: opt: 404, E():
1.7e-17, (35.45% identity in 234 aa overlap);
BAB51608|MLL5100 ferredoxin from Rhizobium loti
(Mesorhizobium loti) (365 aa), FASTA scores: opt: 316,
E(): 5.8e-12, (28.95% identity in 349 aa overlap); etc.
C-terminus also similar to P96853|Rv3571|MTCY06G11.18
putative electron transfer protein from Mycobacterium
tuberculosis (358 aa), FASTA scores: opt: 450, E():
3.6e-20, (32.95% identity in 358 aa overlap). Contains
PS00197 2Fe-2S ferredoxins, iron-sulfur binding region
signature. Belongs to the 2FE2S plant-type ferredoxin
family. Cofactor: binds a 2FE-2S cluster (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3554"
/db_xref="EnsemblGenomes-Tr:CCP46376"
/db_xref="GOA:P71846"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR001433"
/db_xref="InterPro:IPR005804"
/db_xref="InterPro:IPR006058"
/db_xref="InterPro:IPR008333"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR036010"
/db_xref="InterPro:IPR039261"
/db_xref="UniProtKB/TrEMBL:P71846"
/inference="protein motif:PROSITE:PS00197"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46376.1"
/translation="MTDACQAEYAIAAMSTVEMDQAAPESAAHHPLPDPGESVPRLAL
PTIGIFLATLTAFVGSTTAYISGWIPFWVTIPVNAAVTFVMFTVVHDASHYAISSIRW
VNGLFGRLAWLFVGPVVAFPAFGYIHIQHHRHSNDDEQDPDTFASHGSLWVLPLRWSM
VEYFYIKYYLPRGRSRPVIEVAETLVMMTLFLTGLIVAIVTGNFWTLAIVFLIPQRIG
LTVLAWWFDWLPHHGLEDTQRSNRYRATRNRVGAEWLFTPVLLSQNYHLVHHLHPSVP
FYRYLRTWRRNEEAYLERNAAISTVFGQQLNPDEYRQWKELNGRLARLLPVRMPARSS
SPHAVLHRIPVASVDPITADATLVTFAVPEALRDAFRFEPGQHVTVRTDLGGQGIRRN
YSICAPATRAQLRIAVKHIPGGAFSTFVANELKAGDVLELMTPTGRFGTPLDPLHRKH
YVGLVAGSGITPVLSILATTLEIETESRFTLIYGNRTKESTMFRAELDRLESRYADRL
EILHVLSSEPLHTPELRGRIDRDKLTRWLTSTLRPAGVDEWFICGPLAMATAVRETLI
EHGVDSERIHLELFYGFDTPPATRPSYAGATVTFTLSGQRAIFDLVPGDSILEGALGL
RSDAPYACMGGACGTCRAKLIEGNVEMDHNFALRKAELDAGYILTCQSHPTTPFVAVD
YDA"
gene complement(3994830..3995699)
/locus_tag="Rv3555c"
CDS complement(3994830..3995699)
/codon_start=1
/transl_table=11
/locus_tag="Rv3555c"
/product="Conserved protein"
/note="Rv3555c, (MTCY06G11.02c), len: 289 aa. Conserved
protein, highly similar to others from Mycobacterium
tuberculosis e.g. O53562|AL022022|Rv3517|MTV023.24 (279
aa), FASTA scores: opt: 874, E(): 8.3e-48, (49.45%
identity in 275 aa overlap); P71763|Rv1482c|MTCY277.03c
(339 aa),FASTA scores: opt: 755, E(): 3e-40, (45.75%
identity in 260 aa overlap); O69681|Rv3714c|MTV025.062c
(296 aa), FASTA scores: opt: 733, E(): 6.4e-39, (44.1%
identity in 281 aa overlap); etc. Also highly similar to
other mycobacterial hypothetical proteins e.g.
O07396|MAV346 from Mycobacterium avium (346 aa), FASTA
scores: opt: 714, E(): 1.1e-37,(44.6% identity in 260 aa
overlap); and Q50134|U650AG|MLCB57.67c from Mycobacterium
leprae (75 aa),FASTA scores: opt: 130, E(): 0.17, (35.1%
identity in 57 aa overlap) (only partial homology with
this protein). Shows some similarity to P52392|NHSR_STRAS
putative nosiheptide resistance regulatory protein
(ORF699) from Streptomyces actuosus (233 aa), FASTA
scores: opt: 120, E(): 1.9,(25.25% identity in 194 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3555c"
/db_xref="EnsemblGenomes-Tr:CCP46377"
/db_xref="GOA:P96837"
/db_xref="InterPro:IPR011335"
/db_xref="UniProtKB/TrEMBL:P96837"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46377.1"
/translation="MDELPWPVLGSEVLAAKAIPERAMRQLYEPVYPGVYAPAGVELT
ARQRAHAAWLWSRRRAVVAGNSAAALLGAKWVNPALDAELVHANRKPPPRIVVHTDRL
APHETVAVDGVAVTTPARTAFDIGRRTPSRLQAVQRLDALANSTDVKVADVQAVIAEH
TGARGLVRLRAVLPLIDGGAESPQETWTRLVLIDAGLPKPQTQIRVFDDYGDFVARID
LGYEQLRVGVEYDGPQHWTDPAQRARDIERSTALLDLGWTIIRVTSELLWYRRGTFVG
RVDAAMRAAGWRP"
gene complement(3995804..3996964)
/gene="fadA6"
/locus_tag="Rv3556c"
CDS complement(3995804..3996964)
/codon_start=1
/transl_table=11
/gene="fadA6"
/locus_tag="Rv3556c"
/product="Probable acetyl-CoA acetyltransferase FadA6
(acetoacetyl-CoA thiolase)"
/note="Rv3556c, (MTCY06G11.03), len: 386 aa. Probable
fadA6, acetyl-CoA acetyltransferase, similar to many e.g.
Q9K409|2SCG61.06c from Streptomyces coelicolor (389
aa),FASTA scores: opt: 1091, E(): 2.9e-58, (48.1% identity
in 399 aa overlap); Q9AAT4|CC0510 from Caulobacter
crescentus (391 aa), FASTA scores: opt: 902, E(): 6.6e-47,
(40.25% identity in 395 aa overlap); P45359|THL_CLOAB from
Clostridium acetobutylicum (392 aa), FASTA scores: opt:
872, E(): 4.2e-45, (37.9% identity in 396 aa overlap);
Q9I2A8|ATOB|PA2001 from Pseudomonas aeruginosa (393
aa),FASTA scores: opt: 872, E(): 4.2e-45, (41.3% identity
in 397 aa overlap); etc. Contains PS00737 Thiolases
signature 2. Belongs to the thiolase family."
/db_xref="EnsemblGenomes-Gn:Rv3556c"
/db_xref="EnsemblGenomes-Tr:CCP46378"
/db_xref="GOA:I6XHJ3"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020613"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/TrEMBL:I6XHJ3"
/inference="protein motif:PROSITE:PS00737"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46378.1"
/translation="MTEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDID
PAAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQA
IMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRG
SELIAEKWNLSREEMERYSLTSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRES
SLEKMAGLQPLVEGGRLTAAMASQISDGASAVLLASERAVKDHGLRPRARIHHISARA
ADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAWLKEIKADPAKVNPN
GGAIALGHPLGATGAKLFTTMLGELERIGGRYGLQTMCEGGGTANVTIIERL"
gene complement(3997029..3997631)
/locus_tag="Rv3557c"
CDS complement(3997029..3997631)
/codon_start=1
/transl_table=11
/locus_tag="Rv3557c"
/product="Transcriptional regulatory protein (probably
TetR-family)"
/note="Rv3557c, (MTCY06G11.04c), len: 200 aa.
Transcriptional regulator, TetR family, similar to other
e.g. Q9RRV9|DR2376 from Deinococcus radiodurans (197 aa)
FASTA scores: opt: 326, E(): 2.3e-14, (31.2% identity in
189 aa overlap); Q9HZW2|PA2885 from Pseudomonas aeruginosa
(198 aa), FASTA scores: opt: 308, E(): 3.5e-13, (31.55%
identity in 187 aa overlap); Q9RFR4 from Pseudomonas
fluorescens (207 aa), FASTA scores: opt: 291, E():
4.7e-12,(29.75% identity in 195 aa overlap); Q9K8P5|BH2958
from Bacillus halodurans (215 aa), FASTA scores: opt: 271,
E(): 9.9e-11, (23.95% identity in 192 aa overlap); etc.
Also similar to proteins from Mycobacterium tuberculosis
e.g. O53641|Rv0158|MTV032.01 (214 aa), FASTA scores: opt:
232,E(): 3.5e-08, (25.5% identity in 192 aa overlap); and
O06169|Rv2506|MTCY07A7.12 (215 aa), FASTA scores: opt:
215,E(): 4.5e-07, (35.15% identity in 148 aa overlap);
etc. Seems to belong to the TetR/AcrR family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3557c"
/db_xref="EnsemblGenomes-Tr:CCP46379"
/db_xref="GOA:P9WMB9"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="InterPro:IPR041490"
/db_xref="PDB:4W1U"
/db_xref="PDB:4W97"
/db_xref="UniProtKB/Swiss-Prot:P9WMB9"
/protein_id="CCP46379.1"
/translation="MDRVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILS
GSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTANPLERLQGLFMASFEAIEHHH
AQVVIYQDEAQRLASQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRF
IRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKEGV"
gene 3997980..3999638
/gene="PPE64"
/locus_tag="Rv3558"
CDS 3997980..3999638
/codon_start=1
/transl_table=11
/gene="PPE64"
/locus_tag="Rv3558"
/product="PPE family protein PPE64"
/note="Rv3558, (MTCY06G11.05), len: 552 aa. PPE64, Member
of the Mycobacterium tuberculosis PPE family of
glycine-rich proteins, similar to many e.g.
P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt:
1908, E(): 1.7e-83, (58.5% identity in 583 aa overlap).
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3558"
/db_xref="EnsemblGenomes-Tr:CCP46380"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR002989"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q6MWW0"
/protein_id="CCP46380.1"
/translation="MAHFSVLPPEINSLRMYLGAGSAPMLQAAAAWDGLAAELGTAAS
SFSSVTTGLTGQAWQGPASAAMAAAAAPYAGFLTTASAQAQLAAGQAKAVASVFEAAK
AAIVPPAAVAANREAFLALIRSNWLGLNAPWIAAVESLYEEYWAADVAAMTGYHAGAS
QAAAQLPLPAGLQQFLNTLPNLGIGNQGNANLGGGNTGSGNIGNGNKGSSNLGGGNIG
NNNIGSGNRGSDNFGAGNVGTGNIGFGNQGPIDVNLLATPGQNNVGLGNIGNNNMGFG
NTGDANTGGGNTGNGNIGGGNTGNNNFGFGNTGNNNIGIGLTGNNQMGINLAGLLNSG
SGNIGIGNSGTNNIGLFNSGSGNIGVFNTGANTLVPGDLNNLGVGNSGNANIGFGNAG
VLNTGFGNASILNTGLGNAGELNTGFGNAGFVNTGFDNSGNVNTGNGNSGNINTGSWN
AGNVNTGFGIITDSGLTNSGFGNTGTDVSGFFNTPTGPLAVDVSGFFNTASGGTVING
QTSGIGNIGVPGTLFGSVRSGLNTGLFNMGTAISGLFNLRQLLG"
gene complement(3999647..4000435)
/locus_tag="Rv3559c"
CDS complement(3999647..4000435)
/codon_start=1
/transl_table=11
/locus_tag="Rv3559c"
/product="Probable oxidoreductase"
/note="Rv3559c, (MTCY06G11.06c), len: 262 aa. Probable
oxidoreductase, similar to various oxidoreductases e.g.
Q9F5J1|SIM-NJ1|SIMD2 putative 3-keto-acyl-reductase (SDR
family) from Streptomyces antibioticus (273 aa), FASTA
scores: opt: 510, E(): 2.8e-24, (40.15% identity in 249 aa
overlap);Q9L2C9|SC7A8.29 putative dehydrogenase from
Streptomyces coelicolor (255 aa), FASTA scores: opt:
500,E(): 1.1e-23, (41.4% identity in 239 aa overlap);
Q9HQ41|FABG|VNG1341G 3-oxoacyl-[acyl-carrier-protein]
reductase from Halobacterium sp. strain NRC-1 (255 aa)
FASTA scores: opt: 500, E(): 1.1e-23, (40.0% identity in
250 aa overlap); etc. Also similar to oxidoreductases from
Mycobacterium tuberculosis eg
Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14
putative oxidoreductase (247 aa), FASTA scores: opt: 497,
E(): 1.6e-23, (39.2% identity in 245 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3559c"
/db_xref="EnsemblGenomes-Tr:CCP46381"
/db_xref="GOA:I6YCF0"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:I6YCF0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46381.1"
/translation="MNLSVAPKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGA
DVVISDHHERRLGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMGRLDVLV
NNAGLGGQTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPHGGVIVNNASVLG
WRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSIARHKFLDKTASAELLD
RLAAGEAFGRAAEPWEVAATIAFLASDYSSYLTGEVISVSCQHP"
gene complement(4000432..4001589)
/gene="fadE30"
/locus_tag="Rv3560c"
CDS complement(4000432..4001589)
/codon_start=1
/transl_table=11
/gene="fadE30"
/locus_tag="Rv3560c"
/product="Probable acyl-CoA dehydrogenase FadE30"
/note="Rv3560c, (MTCY06G11.07c), len: 385 aa. Probable
fadE30, acyl-CoA dehydrogenase, similar to many e.g.
Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA
scores: opt: 845, E(): 1.6e-47, (39.2% identity in 388 aa
overlap); Q9A5G9|CC2478 from Caulobacter crescentus (407
aa), FASTA scores: opt: 734, E(): 2.8e-40, (35.5% identity
in 386 aa overlap); Q9RJX2|SCF37.29c from Streptomyces
coelicolor (393 aa), FASTA scores: opt: 656, E():
3.2e-35,(37.9% identity in 351 aa overlap); etc. Also
similar to acyl-CoA dehydrogenases from Mycobacterium
tuberculosis e.g. P95280|FADE17|Rv1934c|MTCY09F9.30 (409
aa), FASTA scores: opt: 939, E(): 1.4e-53, (43.8% identity
in 404 aa overlap). Could belong to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3560c"
/db_xref="EnsemblGenomes-Tr:CCP46382"
/db_xref="GOA:I6Y3V5"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:I6Y3V5"
/protein_id="CCP46382.1"
/translation="MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGREHEAFEERRA
WNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLI
AFGTPQQQRRFLPRIRDVTELWCQGYSEPGAGSDLASVATTAELDGDQWVINGQKVWT
SLAHLSQWCFVLARTEKGSQRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDD
ARTDADLVVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADDP
LIRERLTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWANWHRNLGELAMDVIG
KPGMTMPDGEFDEWQRLYLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG"
gene 4001637..4003160
/gene="fadD3"
/locus_tag="Rv3561"
CDS 4001637..4003160
/codon_start=1
/transl_table=11
/gene="fadD3"
/locus_tag="Rv3561"
/product="Probable fatty-acid-CoA ligase FadD3
(fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)"
/note="Rv3561, (MTCY06G11.08), len: 507 aa. Probable
fadD3,fatty-acid-CoA synthetase, similar to many
substrate-CoA symthetases/ligases e.g. Q9KBC2|BH2006
long-chain acyl-CoA synthetase from Bacillus halodurans
(513 aa), FASTA scores: opt: 821, E(): 1.6e-43, (32.9%
identity in 517 aa overlap); Q9EY88|FCS feruloyl-CoA
synthetase from Amycolatopsis sp. HR167 (491 aa) FASTA
scores: opt: 767, E(): 3.5e-40,(37.65% identity in 502 aa
overlap); Q9ZIP5|MATB malonyl CoA synthetase from
Rhizobium leguminosarum (504 aa), FASTA scores: opt: 758,
E(): 1.3e-39, (33.7% identity in 472 aa overlap);
Q9CD27|FADD2|ML2546 acyl-CoA synthase from Mycobacterium
leprae (548 aa), FASTA scores: opt: 700, E(): 5.6e-36,
(31.85% identity in 515 aa overlap);
P29212|LCFA_ECOLI|FADD|OLDD|B1805
long-chain-fatty-acid--CoA ligase from Escherichia coli
strain K12 (561 aa), FASTA scores: opt: 532, E():
6.3e-28,(30.0% identity in 533 aa overlap); etc. Also
similar to other from Mycobacterium tuberculosis eg
O53306|FADD13|Rv3089|MTV013.10 (503 aa), FASTA scores:
opt: 819, E(): 2.1e-43, (35.1% identity in 490 aa
overlap). Contains PS00455 Putative AMP-binding domain
signature."
/db_xref="EnsemblGenomes-Gn:Rv3561"
/db_xref="EnsemblGenomes-Tr:CCP46383"
/db_xref="GOA:P96843"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P96843"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46383.1"
/translation="MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGA
AAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRA
GAPVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVA
ARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINP
FFHNFGYKAGILACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHP
ARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDD
AVTVATTCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDI
GAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVG
RAFVVARPGTGLDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKPQLRELG"
gene 4003161..4004294
/gene="fadE31"
/locus_tag="Rv3562"
CDS 4003161..4004294
/codon_start=1
/transl_table=11
/gene="fadE31"
/locus_tag="Rv3562"
/product="Probable acyl-CoA dehydrogenase FadE31"
/note="Rv3562, (MTCY06G11.09), len: 377 aa. Probable
fadE31, acyl-CoA dehydrogenase, similar to many e.g.
Q9RJX2|SCF37.29c from Streptomyces coelicolor (393
aa),FASTA scores: opt: 657, E(): 1.7e-34, (36.45% identity
in 351 aa overlap); Q9A5G9|CC2478 from Caulobacter
crescentus (407 aa), FASTA scores: opt: 653, E(): 3.2e-34,
(33.95% identity in 392 aa overlap); Q9EX72|MLHC from
Rhodococcus erythropolis (324 aa) FASTA scores: opt: 631,
E(): 6.5e-33,(36.95% identity in 330 aa overlap);
P45867|ACDA_BACSU|ACD from Bacillus subtilis (379 aa),
FASTA scores: opt: 347,E(): 1e-15, (28.6% identity in 385
aa overlap); etc. Also similar to other from Mycobacterium
tuberculosis e.g. P96842|FADE30|Rv3560c|MTCY06G11.07c (385
aa), FASTA scores: opt: 843, E(): 2.3e-46, (38.95%
identity in 380 aa overlap). Could belong to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3562"
/db_xref="EnsemblGenomes-Tr:CCP46384"
/db_xref="GOA:I6YGH7"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:I6YGH7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46384.1"
/translation="MDLNFDDETLAFQAEVREFLAANAASIPTKSYDNAEGFAQHRYW
DRVLFDAGLSVITWPAKYGGRDAPLLHWIVFEEEYFRAGAPGRASANGTSMLAPTLFA
HGTAEQLDRILPKMASGEQIWAQAWSEPESGSDLASLRSTASKVDGGWLLNGQKIWSS
RAPFADMGFGLFRSDPAVERHRGLTYFMFDLKAKGVTVRPIAQLGGDTGFGEIFLDDV
FVPDRDVIGAPNDGWRAAMSTSSNERGMSLRSPARFLASAERLVQLWKDRGSPPEFAD
RVADAWIKAQAYRLQTFGTVTRLAAGGELGAESSVTKVFWSELDVHLHQTALDLRGAD
GELAGPWTEGLLFALGGPIYAGTNEIQRNIIAERLLGLPREKT"
gene 4004291..4005250
/gene="fadE32"
/locus_tag="Rv3563"
CDS 4004291..4005250
/codon_start=1
/transl_table=11
/gene="fadE32"
/locus_tag="Rv3563"
/product="Probable acyl-CoA dehydrogenase FadE32"
/note="Rv3563, (MTCY06G11.10), len: 319 aa. Probable
fadE32, acyl-CoA dehydrogenase, similar to many e.g.
Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA
scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa
overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor
(362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4%
identity in 349 aa overlap); Q9A5G8|CC2479 from
Caulobacter crescentus (344 aa), FASTA scores: opt: 285,
E(): 4.1e-10,(30.4% identity in 329 aa overlap);
P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),
FASTA scores: opt: 230,E(): 1.1e-07, (25.5% identity in
357 aa overlap); etc. Also similar to other from
Mycobacterium tuberculosis eg
P96846|FADE33|Rv3564|MTCY06G11.11 (318 aa), FASTA scores:
opt: 478, E(): 7.6e-22, (32.9% identity in 292 aa
overlap). Could belong to the acyl-CoA dehydrogenases
family."
/db_xref="EnsemblGenomes-Gn:Rv3563"
/db_xref="EnsemblGenomes-Tr:CCP46385"
/db_xref="GOA:P96845"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:P96845"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46385.1"
/translation="MTMEFALNEQQRDFAASIDAALGAADLPGVVRAWAAGDVAPGRK
VWQQLANLGVTALGVAEKFDGLGASPVDLVVALERLGRWCVPGPVTESIAVAPILLAH
DDQAERSHGLASGELIATVAMPPRVPRAVDADTAGLVLLAGDGSVTEGTPGDCHRSVD
PSRRLYEVAASGQAWRAPKDVVARAYEFGALATAAQLVGAGQALLEAAVNYAKQRTQF
GRAIGSYQAIKHKLADVHIAIELACPLVYGAAVSLEPRDVSAAKAAASEAALLAARWA
LQTHGAIGFTCEHDLSLWLLRVQALHSAWGTPQEHRRRVLEAL"
gene 4005247..4006203
/gene="fadE33"
/locus_tag="Rv3564"
CDS 4005247..4006203
/codon_start=1
/transl_table=11
/gene="fadE33"
/locus_tag="Rv3564"
/product="Probable acyl-CoA dehydrogenase FadE33"
/note="Rv3564, (MTCY06G11.11), len: 318 aa. Probable
fadE33, acyl-CoA dehydrogenase, similar to others e.g.
Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA
scores: opt: 373, E(): 1.9e-15, (34.3% identity in 338 aa
overlap); Q9I4V4|PA1020 from Pseudomonas aeruginosa (370
aa), FASTA scores: opt: 277, E(): 1.4e-09, (31.95%
identity in 335 aa overlap); Q9X7Y6|SC6A5.40c from
Streptomyces coelicolor (395 aa), FASTA scores: opt: 273,
E(): 2.5e-09,(30.1% identity in 352 aa overlap);
P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),
FASTA scores: opt: 478,E(): 7.9e-22, (32.9% identity in
292 aa overlap); etc. Also similar to others from
Mycobacterium tuberculosis e.g.
P96845|FADE32|Rv3563|MTCY06G11.10 (319 aa), FASTA scores:
opt: 478, E(): 7.9e-22, (32.9% identity in 292 aa
overlap). Could belong to the acyl-CoA dehydrogenases
family."
/db_xref="EnsemblGenomes-Gn:Rv3564"
/db_xref="EnsemblGenomes-Tr:CCP46386"
/db_xref="GOA:I6YCF5"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/TrEMBL:I6YCF5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46386.1"
/translation="MTPPEERQMLRETVASLVAKHAGPAAVRAAMASDRGYDESLWRL
LCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLGTTLAELALLAAAKP
DAQALTELAQGSAIGALVLDPDYVVNGDIADIVVAATSGQLTRWTRFSAQPVATMDPT
RRLARLQSEETEPLCPDPGIADTAAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIG
SFQALKHRMADLYVTIAAARAVVADACHAPTPTNAATARLAASEALSTAAAEGIQLHG
GIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP"
gene 4006200..4007366
/gene="aspB"
/locus_tag="Rv3565"
CDS 4006200..4007366
/codon_start=1
/transl_table=11
/gene="aspB"
/locus_tag="Rv3565"
/product="Possible aspartate aminotransferase AspB
(transaminase A) (ASPAT) (glutamic--oxaloacetic
transaminase) (glutamic--aspartic transaminase)"
/note="Rv3565, (MTCY06G11.12), len: 388 aa. Possible
aspB,aspartate aminotransferase, similar to many e.g.
Q9A5J2|CC2455 aminotransferase class I from Caulobacter
crescentus (381 aa), FASTA scores: opt: 1112, E():
1e-61,(45.85% identity in 384 aa overlap); Q9HV76|PA4722
probable aminotransferase from Pseudomonas aeruginosa (390
aa),FASTA scores: opt: 863, E(): 3.1e-46, (37.2% identity
in 390 aa overlap); Q9RWP3|DR0623 aspartate
aminotransferase from Deinococcus radiodurans (388 aa),
FASTA scores: opt: 713, E(): 6.3e-37, (35.5% identity in
383 aa overlap); Q9HQK2|ASPC2|VNG1121G aspartate
aminotransferase from Halobacterium sp. strain NRC-1 (391
aa), FASTA scores: opt: 710, E(): 9.8e-37, (34.45%
identity in 380 aa overlap); O33822|AAT_THEAQ|ASPC
aspartate aminotransferase from Thermus aquaticus (383
aa), FASTA scores: opt: 695, E(): 8.2e-36, (35.1% identity
in 376 aa overlap); etc. Contains PS00105
Aminotransferases class-I pyridoxal-phosphate attachment
site. Belongs to class-I of pyridoxal-phosphate-dependent
aminotransferases. Cofactor: pyridoxal phosphate (by
similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3565"
/db_xref="EnsemblGenomes-Tr:CCP46387"
/db_xref="GOA:P96847"
/db_xref="InterPro:IPR004838"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015424"
/db_xref="PDB:5YHV"
/db_xref="UniProtKB/TrEMBL:P96847"
/inference="protein motif:PROSITE:PS00105"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46387.1"
/translation="MTDRVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAG
APEPVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRHGITVEPDAVVITTGSSG
GFLLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQMLAEI
DPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSC
AWQTSRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAV
SAFTPEATAEADGNLASYAINRSLLLDGLRRIGIDRLAPTDGAFYVYADVSDFTSDSL
AFCSKLLADTGVAIAPGIDFDTARGGSFVRISFAGPSGDIEEALRRIGSWLPSQ"
gene complement(4007331..4008182)
/gene="nat"
/gene_synonym="nhoA"
/locus_tag="Rv3566c"
CDS complement(4007331..4008182)
/codon_start=1
/transl_table=11
/gene="nat"
/gene_synonym="nhoA"
/locus_tag="Rv3566c"
/product="Arylamine N-acetyltransferase Nat (arylamine
acetylase)"
/note="Rv3566c, (MT3671, MTCY06G11.13c), len: 283 aa. Nat
(alternate gene name: nhoA), arylamine N-acetyltransferase
(see citations below), highly similar to O86309|NAT_MYCSM
arylamine N-acetyltransferase from Mycobacterium smegmatis
(see citation below) (275 aa), FASTA scores: opt:
1114,E(): 3e-66, (60.95% identity in 274 aa overlap). Also
highly similar to others e.g. Q98D42|BAB51429|MLR4870 from
Rhizobium loti (Mesorhizobium loti) (278 aa), FASTA
scores: opt: 697, E(): 1.1e-38, (44.1% identity in 272 aa
overlap); P77567|NHOA_ECOLI|B1463 from Escherichia coli
strain K12 (281 aa), FASTA scores: opt: 537, E(): 4.4e-28,
(38.85% identity in 273 aa overlap); Q00267|NHOA_SALTY
from Salmonella typhimurium (281 aa), FASTA scores: opt:
507,E(): 4.3e-26, (34.8% identity in 273 aa overlap); etc.
Belongs to the arylamine N-acetyltransferase family. Note
that previously known as nhoA (332 aa) and that nucleotide
4007874 has been changed since first submission (G
deleted)."
/db_xref="EnsemblGenomes-Gn:Rv3566c"
/db_xref="EnsemblGenomes-Tr:CCP46388"
/db_xref="GOA:P9WJI5"
/db_xref="InterPro:IPR001447"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/Swiss-Prot:P9WJI5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46388.1"
/translation="MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPL
LGVPVDDLSPQALADKLVLRRRGGYCFEHNGLMGYVLAELGYRVRRFAARVVWKLAPD
APLPPQTHTLLGVTFPGSGGCYLVDVGFGGQTPTSPLRLETGAVQPTTHEPYRLEDRV
DGFVLQAMVRDTWQTLYEFTTQTRPQIDLKVASWYASTHPASKFVTGLTAAVITDDAR
WNLSGRDLAVHRAGGTEKIRLADAAAVVDTLSERFGINVADIGERGALETRIDELLAR
QPGADAP"
gene complement(4008167..4008433)
/locus_tag="Rv3566A"
CDS complement(4008167..4008433)
/codon_start=1
/transl_table=11
/locus_tag="Rv3566A"
/product="Hypothetical protein"
/note="Rv3566A, len: 88 aa. Hypothetical unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3566A"
/db_xref="EnsemblGenomes-Tr:CCP46389"
/db_xref="UniProtKB/TrEMBL:I6YGI1"
/protein_id="CCP46389.1"
/translation="MSGADPPTRRAFGQMARAATGWVSVSGQFAVAADTCRCEGTLFA
VDPETHVANHNRCDIVGRLRDERPNTLRSVRRGDEVRMATWHWI"
gene complement(4008719..4009282)
/gene="hsaB"
/locus_tag="Rv3567c"
CDS complement(4008719..4009282)
/codon_start=1
/transl_table=11
/gene="hsaB"
/locus_tag="Rv3567c"
/product="Possible oxidoreductase. Possible
3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione
hydroxylase."
/note="Rv3567c, (MTCY06G11.14c), len: 187 aa. Possible
hsaB, oxidoreductase, similar to various oxidoreductases
and hypothetical proteins e.g. O69360 ORF61 protein from
Rhodococcus erythropolis (194 aa) FASTA scores: opt:
974,E(): 3e-59, (77.05% identity in 183 aa overlap);
Q9JN75|MMYF putative oxidoreductase from Streptomyces
coelicolor (174 aa), FASTA scores: opt: 451, E():
1e-23,(43.65% identity in 158 aa overlap);
P54990|NTAB_CHEHE|NMOB nitrilotriacetate monooxygenase
component B from Chelatobacter heintzii (322 aa), FASTA
scores: opt: 409,E(): 1.3e-20, (38.3% identity in 167 aa
overlap)Chelatobacter heintzii; AAK62356 putative NADH:FMN
oxidoreductase from Burkholderia sp. DBT1 (177 aa), FASTA
scores: opt: 360, E(): 1.6e-17, (36.15% identity in 155 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3567c"
/db_xref="EnsemblGenomes-Tr:CCP46390"
/db_xref="GOA:P9WND9"
/db_xref="InterPro:IPR002563"
/db_xref="InterPro:IPR012349"
/db_xref="UniProtKB/Swiss-Prot:P9WND9"
/protein_id="CCP46390.1"
/translation="MSAQIDPRTFRSVLGQFCTGITVITTVHDDVPVGFACQSFAALS
LEPPLVLFCPTKVSRSWQAIEASGRFCVNVLTEKQKDVSARFGSKEPDKFAGIDWRPS
ELGSPIIEGSLAYIDCTVASVHDGGDHFVVFGAVESLSEVPAVKPRPLLFYRGDYTGI
EPEKTTPAHWRDDLEAFLITTTQDTWL"
gene complement(4009297..4010199)
/gene="hsaC"
/gene_synonym="bphC"
/locus_tag="Rv3568c"
CDS complement(4009297..4010199)
/codon_start=1
/transl_table=11
/gene="hsaC"
/gene_synonym="bphC"
/locus_tag="Rv3568c"
/product="3,4-DHSA dioxygenase"
/note="Rv3568c, (MTCY06G11.15c), len: 300 aa. HsaC, highly
similar to e.g. Q9KWQ5|BPHC5 from Rhodococcus sp. RHA1
(300 aa), FASTA scores: opt: 1715, E(): 3.8e-103, (82.15%
identity in 297 aa overlap); O50479|EDOB from Rhodococcus
rhodochrous (300 aa) FASTA scores: opt: 1714, E():
4.4e-103, (82.5% identity in 297 aa overlap); O69359|BPHC6
from Rhodococcus erythropolis (300 aa), FASTA scores: opt:
1647, E(): 9.1e-99, (78.25% identity in 299 aa overlap);
Q9RBT2|BPHC1 from Pseudomonas sp. SY5 (301 aa) Pseudomonas
sp. SY5 (298 aa) FASTA scores: opt: 767, E():
3.9e-42,(42.8% identity in 299 aa overlap);
P47228|BPHC_BURCE from Burkholderia cepacia (Pseudomonas
cepacia) (297 aa), FASTA scores: opt: 670, E(): 6.8e-36,
(40.55% identity in 296 aa overlap); etc. Contains PS00082
Extradiol ring-cleavage dioxygenases signature. Belongs to
the extradiol ring-cleavage dioxygenase family."
/db_xref="EnsemblGenomes-Gn:Rv3568c"
/db_xref="EnsemblGenomes-Tr:CCP46391"
/db_xref="GOA:P9WNW7"
/db_xref="InterPro:IPR000486"
/db_xref="InterPro:IPR004360"
/db_xref="InterPro:IPR029068"
/db_xref="InterPro:IPR037523"
/db_xref="PDB:2ZI8"
/db_xref="PDB:2ZYQ"
/db_xref="UniProtKB/Swiss-Prot:P9WNW7"
/inference="protein motif:PROSITE:PS00082"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46391.1"
/translation="MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRM
DDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRVD
EMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFY
RDVLGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMV
EVEQADDVGLCLDRALRRKVPMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDD
RDWIARESTAVSLWGHDFTVGARG"
gene complement(4010196..4011071)
/gene="hsaD"
/gene_synonym="bphD"
/locus_tag="Rv3569c"
CDS complement(4010196..4011071)
/codon_start=1
/transl_table=11
/gene="hsaD"
/gene_synonym="bphD"
/locus_tag="Rv3569c"
/product="4,9-DHSA hydrolase"
/note="Rv3569c, (MTCY06G11.16c), len: 291 aa. HsaD, highly
similar to e.g. Q9KWQ6|BPHD2 from Rhodococcus sp. RHA1
(292 aa), FASTA scores: opt: 1468, E(): 1.3e-85, (75.5%
identity in 294 aa overlap); Q52036 from Pseudomonas
putida (286 aa), FASTA scores: opt: 785, E(): 1.9e-42,
(45.1% identity in 295 aa overlap); Q52011|BPHD from
Pseudomonas pseudoalcaligenes (286 aa), FASTA scores: opt:
774, E(): 9.3e-42, (44.05% identity in 295 aa overlap);
P47229|BPHD_BURCE from Burkholderia cepacia (Pseudomonas
cepacia) (286 aa) FASTA scores: opt: 772, E():
1.2e-41,(44.5% identity in 295 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A. Similar to
alpha/beta hydrolase fold."
/db_xref="EnsemblGenomes-Gn:Rv3569c"
/db_xref="EnsemblGenomes-Tr:CCP46392"
/db_xref="GOA:P9WNH5"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:2VF2"
/db_xref="PDB:2WUD"
/db_xref="PDB:2WUE"
/db_xref="PDB:2WUF"
/db_xref="PDB:2WUG"
/db_xref="PDB:5JZB"
/db_xref="PDB:5JZS"
/db_xref="UniProtKB/Swiss-Prot:P9WNH5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46392.1"
/translation="MTATEELTFESTSRFAEVDVDGPLKLHYHEAGVGNDQTVVLLHG
GGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRYAAMALKGLFDQ
LGLGRVPLVGNSLGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSK
FSVAPTRENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAGADFE
AGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKF
DEFNKLTIEFLGGGR"
gene complement(4011086..4012270)
/gene="hsaA"
/locus_tag="Rv3570c"
CDS complement(4011086..4012270)
/codon_start=1
/transl_table=11
/gene="hsaA"
/locus_tag="Rv3570c"
/product="Possible oxidoreductase. Possible
3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione
hydroxylase."
/note="Rv3570c, (MTCY06G11.17c), len: 394 aa. Possible
hsaA, oxidoreductase, most similar to hydroxylases and
oxygenases (and also some similarity to acyl-CoA
dehydrogenases) e.g. O69349 hydroxylase from Rhodococcus
erythropolis (393 aa), FASTA scores: opt: 958, E():
1.1e-53, (39.95% identity in 383 aa overlap);
P26698|PIGM_RHOSO pigment protein from Rhodococcus sp.
strain ATCC 21145 (387 aa), FASTA scores: opt: 665, E():
5.4e-35, (32.2% identity in 382 aa overlap); Q9ZGA9|LANZ5
oxygenase homolog from Streptomyces cyanogenus (397 aa)
FASTA scores: opt: 588, E(): 4.5e-30, (30.55% identity in
386 aa overlap); Q9F0J3|NCNH hydroxylase from Streptomyces
arenae (405 aa), FASTA scores: opt: 580, E():
1.5e-29,(31.25% identity in 336 aa overlap); O69789|BPFA
indole dioxygenase from Rhodococcus opacus (399 aa), FASTA
scores: opt: 558, E(): 3.7e-28, (31.8% identity in 387 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3570c"
/db_xref="EnsemblGenomes-Tr:CCP46393"
/db_xref="GOA:P9WJA1"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013107"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="PDB:3AFE"
/db_xref="PDB:3AFF"
/db_xref="UniProtKB/Swiss-Prot:P9WJA1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46393.1"
/translation="MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKAL
DDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQR
AQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKD
GRPVDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTA
GGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDD
PFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSI
ASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDT
MV"
gene 4012417..4013493
/gene="kshB"
/gene_synonym="hmp"
/locus_tag="Rv3571"
CDS 4012417..4013493
/codon_start=1
/transl_table=11
/gene="kshB"
/gene_synonym="hmp"
/locus_tag="Rv3571"
/product="Reductase component of
3-ketosteroid-9-alpha-hydroxylase KshB"
/note="Rv3571, (MTCY06G11.18), len: 358 aa. kshB,
reductase component of 3-ketosteroid-9-alpha-hydroxylase,
similar to several e.g. Q44253|ATDA5 aniline dioxygenase
reductase component from Acinetobacter sp (336 aa) FASTA
scores: opt: 748, E(): 1.5e-38, (34.95% identity in 346 aa
overlap); P95533|TDNB electron transfer protein from
Pseudomonas putida (337 aa), FASTA scores: opt: 723, E():
5.2e-37,(36.35% identity in 341 aa overlap);
AAK65059|SMA0752 possible dioxygenase reductase subunit
from Rhizobium meliloti (Sinorhizobium meliloti) (353 aa)
FASTA scores: opt: 495, E(): 4.9e-23, (31.9% identity in
345 aa overlap); P76081|PAAE_ECOLI|B1392 probable
phenylacetic acid degradation NADH oxidoreductase (356
aa), FASTA scores: opt: 364, E(): 5.1e-15, (34.45%
identity in 357 aa overlap); Q9L131|HMPA flavohemoprotein
from Streptomyces coelicolor (398 aa), FASTA scores: opt:
352, E(): 3e-14,(32.8% identity in 247 aa overlap); etc.
Contains PS00197 2Fe-2S ferredoxins, iron-sulfur binding
region signature. Note that it has been shown hmp
transcription increased at early stationary phase and is
lower at late stationary phase and during exponential
growth. Note that previously known as hmp."
/db_xref="EnsemblGenomes-Gn:Rv3571"
/db_xref="EnsemblGenomes-Tr:CCP46394"
/db_xref="GOA:P9WJ93"
/db_xref="InterPro:IPR001041"
/db_xref="InterPro:IPR001433"
/db_xref="InterPro:IPR001709"
/db_xref="InterPro:IPR006058"
/db_xref="InterPro:IPR008333"
/db_xref="InterPro:IPR012675"
/db_xref="InterPro:IPR017927"
/db_xref="InterPro:IPR017938"
/db_xref="InterPro:IPR036010"
/db_xref="InterPro:IPR039261"
/db_xref="UniProtKB/Swiss-Prot:P9WJ93"
/inference="protein motif:PROSITE:PS00197"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46394.1"
/translation="MTEAIGDEPLGDHVLELQIAEVVDETDEARSLVFAVPDGSDDPE
IPPRRLRYAPGQFLTLRVPSERTGSVARCYSLCSSPYTDDALAVTVKRTADGYASNWL
CDHAQVGMRIHVLAPSGNFVPTTLDADFLLLAAGSGITPIMSICKSALAEGGGQVTLL
YANRDDRSVIFGDALRELAAKYPDRLTVLHWLESLQGLPSASALAKLVAPYTDRPVFI
CGPGPFMQAARDALAALKVPAQQVHIEVFKSLESDPFAAVKVDDSGDEAPATAVVELD
GQTHTVSWPRTAKLLDVLLAAGLDAPFSCREGHCGACACTLRAGKVNMGVNDVLEQQD
LDEGLILACQSRPESDSVEVTYDE"
gene 4013511..4014041
/locus_tag="Rv3572"
CDS 4013511..4014041
/codon_start=1
/transl_table=11
/locus_tag="Rv3572"
/product="Unknown protein"
/note="Rv3572, (MTCY06G11.19), len: 176 aa. Unknown
protein. Predicted to be an outer membrane protein (See
Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3572"
/db_xref="EnsemblGenomes-Tr:CCP46395"
/db_xref="UniProtKB/TrEMBL:I6X7P2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46395.1"
/translation="MTRLIPGCTLVGLMLTLLPAPTSAAGSNTATTLFPVDEVTQLET
HTFLDCHPNGSCDFVAGANLRTPDGPTGFPPGLWARQTTEIRSTNRLAYLDAHATSQF
ERVMKAGGSDVITTVYFGEGPPDKYQTTGVIDSTNWSTGQPMTDVNVIVCTHMQVVYP
GVNLTSPSTCAQANFS"
gene complement(4014077..4016212)
/gene="fadE34"
/locus_tag="Rv3573c"
CDS complement(4014077..4016212)
/codon_start=1
/transl_table=11
/gene="fadE34"
/locus_tag="Rv3573c"
/product="Probable acyl-CoA dehydrogenase FadE34"
/note="Rv3573c, (MTCY06G11.20c), len: 711 aa. Probable
fadE34, acyl-CoA dehydrogenase, similar to
others,especially in C-terminal half, e.g.
Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa)
FASTA scores: opt: 780,E(): 2.8e-39, (44.1% identity in
347 aa overlap); Q9A6N8|CC2049 from Caulobacter crescentus
(401 aa), FASTA scores: opt: 705, E(): 8.7e-35, (41.5%
identity in 342 aa overlap); Q9EX72|MLHC from Rhodococcus
erythropolis (324 aa), FASTA scores: opt: 673, E():
6.1e-33, (42.05% identity in 283 aa overlap);
P41367|ACDM_PIG|ACADM from Sus scrofa (Pig)(421 aa) FASTA
scores: opt: 325, E(): 4.9e- 13, (28.5% identity in 368 aa
overlap); etc. Also similar to others from Mycobacterium
tuberculosis e.g. P95097|FADE22|Rv3061c|MTCY22D7.20 (721
aa), FASTA scores: opt: 1635, E(): 2.7e-90, (42.65%
identity in 729 aa overlap). Could belong to the acyl-CoA
dehydrogenases family."
/db_xref="EnsemblGenomes-Gn:Rv3573c"
/db_xref="EnsemblGenomes-Tr:CCP46396"
/db_xref="GOA:P96855"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR013786"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR037069"
/db_xref="UniProtKB/Swiss-Prot:P96855"
/inference="protein motif:PROSITE:PS01156"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46396.1"
/translation="MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGN
ADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAVAT
LVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAPGGVVLLPADG
NWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLEVSGERVEDLAATVLAAEA
AGVARWTLDTAVAYAKVREQFGKPIGSFQAVKHLCAQMLCRAEQADVAAADAARAAAD
SDGTQLSIAAAVAASIGIDAAKANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLG
GSGRWLRRVTALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTG
LLAPHWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTPEQIERF
VPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTSAAHKARWGVC
LARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITGDSLFNEVFLDNVFVPDEMVVGA
VNDGWRLARTTLANERVAMATGTALGNPMEELLKVLGDMELDVAQQDRLGRLILLAQA
GALLDRRIAELAVGGQDPGAQSSVRKLIGVRYRQALAEYLMEVSDGGGLVENRAVYDF
LNTRCLTIAGGTEQILLTVAAERLLGLPR"
gene 4016484..4017083
/gene="kstR"
/locus_tag="Rv3574"
CDS 4016484..4017083
/codon_start=1
/transl_table=11
/gene="kstR"
/locus_tag="Rv3574"
/product="Transcriptional regulatory protein KstR
(probably TetR-family)"
/note="Rv3574, (MTCY06G11.21), len: 199 aa. Probable
kstR,transcriptional regulator TetR family, similar to
others e.g. Q9KXK1|SCC53.10 from Streptomyces coelicolor
(250 aa) FASTA scores: opt: 492, E(): 4.8e-25, (44.8%
identity in 183 aa overlap); Q9RA03|KSTR from Rhodococcus
erythropolis (208 aa), FASTA scores: opt: 294, E():
3.1e-12, (28.9% identity in 187 aa overlap);
BAB54261|MLR7895 from Rhizobium loti (Mesorhizobium loti)
(193 aa), FASTA scores: opt: 166, E(): 0.00062, (32.05%
identity in 78 aa overlap); P17446|BETI_ECOLI|B0313 from
Escherichia coli strain K12 (195 aa), FASTA scores: opt:
142, E(): 0.0034, (25. 6% identity in 168 aa overlap);
etc. Equivalent to AAK48038 from Mycobacterium
tuberculosis strain CDC1551 (243 aa) but shorter 44 aa.
Contains possible helix-turn-helix motif from aa 37-58
(+3.70 SD). Possibly belongs to the TetR/AcrR family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3574"
/db_xref="EnsemblGenomes-Tr:CCP46397"
/db_xref="GOA:P96856"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR041642"
/db_xref="PDB:3MNL"
/db_xref="PDB:5AQC"
/db_xref="PDB:5CW8"
/db_xref="PDB:5CXG"
/db_xref="PDB:5CXI"
/db_xref="PDB:5FMP"
/db_xref="PDB:5UA1"
/db_xref="PDB:5UA2"
/db_xref="UniProtKB/Swiss-Prot:P96856"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46397.1"
/translation="MAVLAESELGSEAQRERRKRILDATMAIASKGGYEAVQMRAVAD
RADVAVGTLYRYFPSKVHLLVSALGREFSRIDAKTDRSAVAGATPFQRLNFMVGKLNR
AMQRNPLLTEAMTRAYVFADASAASEVDQVEKLIDSMFARAMANGEPTEDQYHIARVI
SDVWLSNLLAWLTRRASATDVSKRLDLAVRLLIGDQDSA"
gene complement(4017089..4018168)
/locus_tag="Rv3575c"
CDS complement(4017089..4018168)
/codon_start=1
/transl_table=11
/locus_tag="Rv3575c"
/product="Transcriptional regulatory protein (probably
LacI-family)"
/note="Rv3575c, (MTCY06G11.22c), len: 359 aa. Probable
transcriptional regulator belonging to lacI family,
similar to others e.g. BAB53947|MLL8376 from Rhizobium
loti (Mesorhizobium loti) (358 aa), FASTA scores: opt:
707, E(): 2.6e-35, (35.5% identity in 355 aa overlap);
Q9RRI9|DR2501 from Deinococcus radiodurans (359 aa) FASTA
scores: opt: 544, E(): 1.6e-25, (40.35% identity in 347 aa
overlap); Q9RL31|SCF51A.34 from Streptomyces coelicolor
(347 aa),FASTA scores: opt: 307, E(): 2.9e-11, (30.0%
identity in 330 aa overlap); O87590|CELR_THEFU from
Thermomonospora fusca (340 aa), FASTA scores: opt: 280,
E(): 1.2e-09,(32.3% identity in 353 aa overlap);
P21867|RAFR_ECOLI from Escherichia coli (335 aa) FASTA
scores: opt: 241, E(): 2.6e-07, (27.15% identity in 269 aa
overlap); etc. Equivalent to AAK48039 from Mycobacterium
tuberculosis strain CDC1551 (404 aa) but shorter 45 aa.
Contains possible helix-turn-helix motif, at aa 9-30
(+5.86 SD). Could belong to the LacI family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3575c"
/db_xref="EnsemblGenomes-Tr:CCP46398"
/db_xref="GOA:P96857"
/db_xref="InterPro:IPR000843"
/db_xref="InterPro:IPR010982"
/db_xref="InterPro:IPR028082"
/db_xref="UniProtKB/TrEMBL:P96857"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46398.1"
/translation="MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQLSADLRERVL
ATAKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQSCEELG
QGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVVLQRRLPVVVVDQPK
DLSGVSRVGIDDRAAMRELAGYVLGLGHRELGLLTMRLGRDRRQDLVDAERLRSPTFD
VQRERIVGVWEAMTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTAD
ILALSAMDYLRAHGIYVPGQMTVTGFDGVPEALSRGLTTVAQPSLHKGHRAGELLLKP
PRSGLPVIEVLDTELVRGRTAGPPA"
gene 4018358..4019071
/gene="lppH"
/gene_synonym="pknM"
/locus_tag="Rv3576"
CDS 4018358..4019071
/codon_start=1
/transl_table=11
/gene="lppH"
/gene_synonym="pknM"
/locus_tag="Rv3576"
/product="Possible conserved lipoprotein LppH"
/note="Rv3576, (MTCY06G11.23), len: 237 aa. Possible
lppH,conserved lipoprotein, similar in part with proteins
from Mycobacterium tuberculosis; C-terminus of
Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50.16 probable
serine/threonine-protein kinase (626 aa) FASTA scores:
opt: 396, E(): 6.5e-19, (36.0% identity in 200 aa
overlap); and with P71740|LPPR|Rv2403c|MTCY253.17 probable
lipoprotein protein (251 aa), FASTA scores: opt: 134, E():
0.087,(22.7% identity in 207 aa overlap). Contains PS00013
Prokaryotic membrane lipoprotein lipid attachment site.
Note that previously known as pknM."
/db_xref="EnsemblGenomes-Gn:Rv3576"
/db_xref="EnsemblGenomes-Tr:CCP46399"
/db_xref="InterPro:IPR026954"
/db_xref="InterPro:IPR038232"
/db_xref="UniProtKB/TrEMBL:I6YGJ4"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46399.1"
/translation="MGKQLAALAALVGACMLAAGCTNVVDGTAVAADKSGPLHQDPIP
VSALEGLLLDLSQINAALGATSMKVWFNAKAMWDWSKSVADKNCLAIDGPAQEKVYAG
TGWTAMRGQRLDDSIDDSKKRDHYAIQAVVGFPTAHDAEEFYSSSVQSWSSCSNRRFV
EVTPGQDDAAWTVADVVNDNGMLSSSQVQEGGDGWTCQRALTARNNVTIDIVTCAYSQ
PDLVAIGIANQIAAKVAKQ"
gene 4019262..4020128
/locus_tag="Rv3577"
CDS 4019262..4020128
/codon_start=1
/transl_table=11
/locus_tag="Rv3577"
/product="Conserved hypothetical protein"
/note="Rv3577, (MTCY06G11.24), len: 288 aa (other start
sites possible upstream; equivalent to AAK48041 from
Mycobacterium tuberculosis strain CDC1551 (379 aa) but
shorter 91 aa). Hypothetical protein, showing some
similarity to Q9RI88|SCJ11.16c hypothetical 37.9 KDA
protein from Streptomyces coelicolor (349 aa) FASTA
scores: opt: 285, E(): 1.5e-10, (27.45% identity in 266 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3577"
/db_xref="EnsemblGenomes-Tr:CCP46400"
/db_xref="GOA:P96859"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:P96859"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46400.1"
/translation="MPTARSDAPLSVTWMGVATLLVDDGSSALMTDGYFSRPGLARVA
AGKVSPSAERVDGCLARANVSRLTAVIPVHTHIDHAMDSALVADRTGAQLVGGESAAN
VGRGYGLPEESLVVAVPGEPIQLGAFDVTLVESHHCPPDRFPGVISAPLTPPVKASAY
RCGEAWSTLVHHRPSGRRLLIQDSAGFVSGALAGYRADAAYLSVGQLGLQPPSYLLEY
WTETVRTVGVRRVILIHWDDFFRPLSKPLRALPYAADDLDLSIRILDELAAQDGVALQ
MPTVWRREDPWM"
gene 4020142..4021383
/gene="arsB2"
/locus_tag="Rv3578"
CDS 4020142..4021383
/codon_start=1
/transl_table=11
/gene="arsB2"
/locus_tag="Rv3578"
/product="Possible arsenical pump integral membrane
protein ArsB2"
/note="Rv3578, (MTCY06G11.25), len: 413 aa. Possible
arsB2,arsenical pump integral membrane protein, similar to
many e.g. Q9I1J6|ARSB|PA2278 from Pseudomonas aeruginosa
(427 aa), FASTA scores: opt: 375, E(): 3.1e-15, (32.15%
identity in 429 aa overlap); Q9K8K7|ARSB|BH2999 from
Bacillus halodurans (436 aa), FASTA scores: opt: 360, E():
2.5e-14,(28.7% identity in 432 aa overlap);
P52146|ARB2_ECOLI from Escherichia coli (plasmid R46) (429
aa), FASTA scores: opt: 345, E(): 2e-13, (29.8% identity
in 426 aa overlap); etc. Also highly similar to
Q9KYM0|SC9H11.21c probable membrane efflux protein from
Streptomyces coelicolor (446 aa), FASTA scores: opt: 730,
E(): 1.7e-36, (53.95% identity in 443 aa overlap). Seems
to belong to the ARS family."
/db_xref="EnsemblGenomes-Gn:Rv3578"
/db_xref="EnsemblGenomes-Tr:CCP46401"
/db_xref="GOA:I6YCG9"
/db_xref="InterPro:IPR000802"
/db_xref="UniProtKB/TrEMBL:I6YCG9"
/protein_id="CCP46401.1"
/translation="MTLAVALILLAVVLGFAVARPRGWPEAAAAVPAAVILLAIGAIS
PQQAMAQVSGLARVVAFLGAVLVLAKLCDDEGLFEAAGAAMARASAESHRLLRQVFAV
SAAITAALCLDATVVLLTPVVLATVRRLRTPVRPYAYATAHLANAASLLLPVSNLTNL
LAYHGAGISFTKFTLLMALPWLSAVAAVYVVFRWFFARDLRVVPDRQQLKPAPRLPMF
VLVVVALTLGGFAVAESVGLAPTWAALAGAAVLALRSLRRGHTSVLRIARAVNVSFLV
FVLALGVVVHAVMLNGMAARMSAVLPTGSGLPALLGIAALAAVLANVVNNLPATLVLV
PLVAAGGPAAVLAVLLGVNIGPNLTYAGSLSNLLWRGVLRRHNVDASVGEYTRLGLCT
VPAALAMAVLALWASAQVLGI"
gene complement(4021425..4022393)
/locus_tag="Rv3579c"
CDS complement(4021425..4022393)
/codon_start=1
/transl_table=11
/locus_tag="Rv3579c"
/product="Possible tRNA/rRNA methyltransferase"
/note="Rv3579c, (MTCY06G11.26c), len: 322 aa. Possible
tRNA/rRNA methyltransferase, equivalent, but longer 31
aa,to Q9CCW4|ML0324 putative methyltransferase from
Mycobacterium leprae (278 aa), FASTA scores: opt:
1517,E(): 3.4e-79, (83.75% identity in 277 aa overlap).
Also highly similar to Q9L0Q5|SCD8A.09 from Streptomyces
coelicolor (314 aa), FASTA scores: opt: 937, E():
3.4e-46,(56.75% identity in 319 aa overlap); and similar
to others e.g. Q06753|YACO_BACSU from Bacillus subtilis
(249 aa),FASTA scores: opt: 616, E(): 4.9e-28, (41.05%
identity in 246 aa overlap); Q9KGF2|BH0113 from Bacillus
halodurans (249 aa), FASTA scores: opt: 596, E(): 6.7e-27,
(38.5% identity in 244 aa overlap);
P74328|Y955_SYNY3|SLR0955 from Synechocystis sp. strain
PCC 6803 (384 aa), FASTA scores: opt: 585, E(): 4e-26,
(35.85% identity in 304 aa overlap);
P39290|YJFH_ECOLI|B4180 from Escherichia coli strain K12
(243 aa), FASTA scores: opt: 521, E(): 1.2e-22, (38.1%
identity in 244 aa overlap); etc. Equivalent to AAK48043
from Mycobacterium tuberculosis strain CDC1551 (253 aa)
but longer 69 aa. Possibly belongs to the RNA
methyltransferase TrmH family."
/db_xref="EnsemblGenomes-Gn:Rv3579c"
/db_xref="EnsemblGenomes-Tr:CCP46402"
/db_xref="GOA:P9WFY5"
/db_xref="InterPro:IPR001537"
/db_xref="InterPro:IPR004441"
/db_xref="InterPro:IPR013123"
/db_xref="InterPro:IPR029026"
/db_xref="InterPro:IPR029028"
/db_xref="InterPro:IPR029064"
/db_xref="UniProtKB/Swiss-Prot:P9WFY5"
/protein_id="CCP46402.1"
/translation="MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLR
PHHPAAKRARAQPRRPVKRADETETVLGRNPVLECLRAGVPATALYVALGTEADERLT
ECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPPYNYAHPDDLLAAALDQPPA
LLVALDNLSDPRNLGAIVRSVAAFGGHGVLIPQRRSASVTAVAWRTSAGAAARIPVAR
ATNLTRTLKGWADRGVRVIGLDAGGGTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCD
EVVSIPMAAQAESLNASVAAGVVLAEIARQRRRPREPREQTQNRMI"
gene complement(4022394..4023803)
/gene="cysS1"
/locus_tag="Rv3580c"
CDS complement(4022394..4023803)
/codon_start=1
/transl_table=11
/gene="cysS1"
/locus_tag="Rv3580c"
/product="Cysteinyl-tRNA synthetase 1 CysS1
(cysteine--tRNA ligase 1) (CYSRS 1) (cysteine translase)"
/note="Rv3580c, (MTCY06G11.27c), len: 469 aa. Probable
cysS1, cysteinyl-tRNA synthetase, equivalent to
P57990|SYC1_MYCLE|CYSS1|CYSS|ML0323 cysteinyl-tRNA
synthetase 1 from Mycobacterium leprae (473 aa) FASTA
scores: opt: 2825, E(): 3.4e-172, (86.5% identity in 467
aa overlap). Also similar to many e.g. Q9L0Q6|SCD8A.08
from Streptomyces coelicolor (613 aa), FASTA scores: opt:
1834,E(): 4.7e-109, (57.5% identity in 461 aa overlap);
Q9I2U7|CYSS|PA1795 from Pseudomonas aeruginosa (460 aa)
FASTA scores: opt: 1197, E(): 1.2e-68, (41.65% identity in
468 aa overlap); P21888|SYC_ECOLI P21888|CYSS|B0526 from
Escherichia coli strain K12 (461 aa), FASTA scores: opt:
1189, E(): 4e-68, (43.0% identity in 463 aa overlap); etc.
Belongs to class-I aminoacyl-tRNA synthetase family.
Strongly similar to methionyl-tRNA synthetase."
/db_xref="EnsemblGenomes-Gn:Rv3580c"
/db_xref="EnsemblGenomes-Tr:CCP46403"
/db_xref="GOA:P9WFW1"
/db_xref="InterPro:IPR009080"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR015273"
/db_xref="InterPro:IPR015803"
/db_xref="InterPro:IPR024909"
/db_xref="InterPro:IPR032678"
/db_xref="UniProtKB/Swiss-Prot:P9WFW1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46403.1"
/translation="MTDRARLRLHDTAAGVVRDFVPLRPGHVSIYLCGATVQGLPHIG
HVRSGVAFDILRRWLLARGYDVAFIRNVTDIEDKILAKAAAAGRPWWEWAATHERAFT
AAYDALDVLPPSAEPRATGHITQMIEMIERLIQAGHAYTGGGDVYFDVLSYPEYGQLS
GHKIDDVHQGEGVAAGKRDQRDFTLWKGEKPGEPSWPTPWGRGRPGWHLECSAMARSY
LGPEFDIHCGGMDLVFPHHENEIAQSRAAGDGFARYWLHNGWVTMGGEKMSKSLGNVL
SMPAMLQRVRPAELRYYLGSAHYRSMLEFSETAMQDAVKAYVGLEDFLHRVRTRVGAV
CPGDPTPRFAEALDDDLSVPIALAEIHHVRAEGNRALDAGDHDGALRSASAIRAMMGI
LGCDPLDQRWESRDETSAALAAVDVLVQAELQNREKAREQRNWALADEIRGRLKRAGI
EVTDTADGPQWSLLGGDTK"
gene complement(4023868..4024347)
/gene="ispF"
/locus_tag="Rv3581c"
CDS complement(4023868..4024347)
/codon_start=1
/transl_table=11
/gene="ispF"
/locus_tag="Rv3581c"
/product="Probable 2C-methyl-D-erythritol
2,4-cyclodiphosphate synthase IspF (MECPS)"
/note="Rv3581c, (MT3687, MTCY06G11.28c), len: 159 aa.
Probable ispF, 2-C-methyl-D-erythritol
2,4-cyclodiphosphate synthase, equivalent to Q9CCW5|ML0322
putative 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
synthase from Mycobacterium leprae (158 aa), FASTA scores:
opt: 830, E(): 2.9e-47, (79.1% identity in 158 aa
overlap). Also highly similar to others e.g.
Q9L0Q7|ISPF_STRCO|SCD8A.07 from Streptomyces coelicolor
(170 aa), FASTA scores: opt: 585,E(): 2.9e-31, (56.5%
identity in 154 aa overlap); Q9PDT5|ISPF_XYLFA|XF1294 from
Xylella fastidiosa (176 aa),FASTA scores: opt: 398, E():
4.6e-19, (44.9% identity in 156 aa overlap);
Q08113|ISDF_RHOCA|ISPDF from Rhodobacter capsulatus
(Rhodopseudomonas capsulata) (379 aa), FASTA scores: opt:
387, E(): 4.5e-18, (42.85% identity in 154 aa overlap)
(only similar with C-terminal end of this bifunctional
protein ISPD and ISPF); Q06756|ISPF_BACSU from Bacillus
subtilis (158 aa), FASTA scores: opt: 367, E(): 4.5e-17,
(41.2% identity in 153 aa overlap); etc. Belongs to the
IspF family."
/db_xref="EnsemblGenomes-Gn:Rv3581c"
/db_xref="EnsemblGenomes-Tr:CCP46404"
/db_xref="GOA:P9WKG5"
/db_xref="InterPro:IPR003526"
/db_xref="InterPro:IPR020555"
/db_xref="InterPro:IPR036571"
/db_xref="UniProtKB/Swiss-Prot:P9WKG5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46404.1"
/translation="MNQLPRVGLGTDVHPIEPGRPCWLVGLLFPSADGCAGHSDGDVA
VHALCDAVLSAAGLGDIGEVFGVDDPRWQGVSGADMLRHVVVLITQHGYRVGNAVVQV
IGNRPKIGWRRLEAQAVLSRLLNAPVSVSATTTDGLGLTGRGEGLAAIATALVVSLR"
gene complement(4024344..4025039)
/gene="ispD"
/locus_tag="Rv3582c"
CDS complement(4024344..4025039)
/codon_start=1
/transl_table=11
/gene="ispD"
/locus_tag="Rv3582c"
/product="4-diphosphocytidyl-2C-methyl-D-erythritol
synthase IspD (MEP cytidylyltransferase) (MCT)"
/note="Rv3582c, (MT3688, MTCY06G11.29c), len: 231 aa.
ispD,4-diphosphocytidyl-2C-methyl-D-erythritol synthase
,equivalent to Q9CCW6|ML0321 putative
4-diphosphocytidyl-2C-methyl-D-erythritol synthase from
Mycobacterium leprae (241 aa), FASTA scores: opt: 694,
E(): 1.7e-35, (66.95% identity in 236 aa overlap). Also
highly similar to others e.g. Q9L0Q8|ISPD_STRCO|SCD8A.06
from Streptomyces coelicolor (270 aa), FASTA scores: opt:
537,E(): 7.5e-26, (43.4% identity in 242 aa overlap);
P74323|ISPD_SYNY3|SLR0951 from Synechocystis sp. strain
PCC 6803 (230 aa), FASTA scores: opt: 410, E():
3.8e-18,(36.15% identity in 224 aa overlap);
Q9KGF8|ISPD_BACHD|BH0107 from Bacillus halodurans (228 aa)
FASTA scores: opt: 367, E(): 1.6e-15, (34.65% identity in
228 aa overlap); Q08113|ISDF_RHOCA|ISPDF from Rhodobacter
capsulatus (Rhodopseudomonas capsulata) (379 aa)FASTA
scores: opt: 359, E(): 7.8e-15, (34.1% identity in 223 aa
overlap) (only similar with N-terminus of this
bifunctional protein ISPD and ISPF);
Q46893|ISPD_ECOLI|B2747 from Escherichia coli strain K12
(235 aa), FASTA scores: opt: 336, E(): 1.3e-13, (33.65%
identity in 223 aa overlap); etc. Belongs to the ISPD
family."
/db_xref="EnsemblGenomes-Gn:Rv3582c"
/db_xref="EnsemblGenomes-Tr:CCP46405"
/db_xref="GOA:P9WKG9"
/db_xref="InterPro:IPR001228"
/db_xref="InterPro:IPR018294"
/db_xref="InterPro:IPR029044"
/db_xref="InterPro:IPR034683"
/db_xref="PDB:2XWN"
/db_xref="PDB:3OKR"
/db_xref="PDB:3Q7U"
/db_xref="PDB:3Q80"
/db_xref="UniProtKB/Swiss-Prot:P9WKG9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46405.1"
/translation="MVREAGEVVAIVPAAGSGERLAVGVPKAFYQLDGQTLIERAVDG
LLDSGVVDTVVVAVPADRTDEARQILGHRAMIVAGGSNRTDTVNLALTVLSGTAEPEF
VLVHDAARALTPPALVARVVEALRDGYAAVVPVLPLSDTIKAVDANGVVLGTPERAGL
RAVQTPQGFTTDLLLRSYQRGSLDLPAAEYTDDASLVEHIGGQVQVVDGDPLAFKITT
KLDLLLAQAIVRG"
gene complement(4025056..4025544)
/locus_tag="Rv3583c"
CDS complement(4025056..4025544)
/codon_start=1
/transl_table=11
/locus_tag="Rv3583c"
/product="Possible transcription factor"
/note="Rv3583c, (MTV024.01c, MTCY06G11.30c), len: 162 aa.
Possible transcriptional factor, identical to
Q9CCW7|ML0320 putative transcription factor from
Mycobacterium leprae (165 aa), FASTA scores: opt: 1004,
E(): 6.1e-56, (97.55% identity in 162 aa overlap); and
Q9ZBM8|MLCB1450.01c putative transcriptional regulator
from Mycobacterium leprae (94 aa), FASTA scores: opt: 600,
E(): 6e-31, (97.85% identity in 94 aa overlap). Also
highly similar to others e.g. Q9L0Q9|SCD8A.05 from
Streptomyces coelicolor (160 aa),FASTA scores: opt: 878,
E(): 4.3e-48, (85.0% identity in 160 aa overlap);
Q9K600|BH3935 from Bacillus halodurans (153 aa) FASTA
scores: opt: 383, E(): 3.1e-17, (36.4% identity in 151 aa
overlap); Q9KD36|BH1383 from Bacillus halodurans (164 aa)
FASTA scores: opt: 305, E(): 2.4e-12,(33.55% identity in
164 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3583c"
/db_xref="EnsemblGenomes-Tr:CCP46406"
/db_xref="GOA:P9WJG3"
/db_xref="InterPro:IPR003711"
/db_xref="InterPro:IPR036101"
/db_xref="InterPro:IPR042215"
/db_xref="PDB:4ILU"
/db_xref="PDB:4KBM"
/db_xref="PDB:4KMC"
/db_xref="PDB:4MFR"
/db_xref="PDB:6EDT"
/db_xref="PDB:6EE8"
/db_xref="PDB:6EEC"
/db_xref="UniProtKB/Swiss-Prot:P9WJG3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46406.1"
/translation="MIFKVGDTVVYPHHGAALVEAIETRTIKGEQKEYLVLKVAQGDL
TVRVPAENAEYVGVRDVVGQEGLDKVFQVLRAPHTEEPTNWSRRYKANLEKLASGDVN
KVAEVVRDLWRRDQERGLSAGEKRMLAKARQILVGELALAESTDDAKAETILDEVLAA
AS"
gene 4025830..4026378
/gene="lpqE"
/locus_tag="Rv3584"
CDS 4025830..4026378
/codon_start=1
/transl_table=11
/gene="lpqE"
/locus_tag="Rv3584"
/product="Possible conserved lipoprotein LpqE"
/note="Rv3584, (MTV024.02), len: 182 aa. Possible
lpqE,conserved lipoprotein, equivalent to
Q9ZBM7|MLCB1450.02|LPQE|ML0319 putative lipoprotein from
Mycobacterium leprae (183 aa), FASTA scores: opt: 722,
E(): 6.2e-37, (63.45% identity in 175 aa overlap). Also
similar in part to Q9KK69 exported protein 996A010
(fragment) from Mycobacterium avium (41 aa), FASTA scores:
opt: 180, E(): 0.00012, (69.25% identity in 39 aa
overlap); and Q9L0R0|SCD8A.04c putative lipoprotein from
Streptomyces coelicolor (241 aa), FASTA scores: opt: 127,
E(): 0.86,(27.15% identity in 173 aa overlap). Equivalent
to AAK48048 from Mycobacterium tuberculosis strain CDC1551
(238 aa) but shorter 56 aa. Contains probable N-terminal
signal sequence and appropriately positioned PS00013
Prokaryotic membrane lipoprotein lipid attachment site. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3584"
/db_xref="EnsemblGenomes-Tr:CCP46407"
/db_xref="GOA:P9WK63"
/db_xref="UniProtKB/Swiss-Prot:P9WK63"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46407.1"
/translation="MNRCNIRLRLAGMTTWVASIALLAAALSGCGAGQISQTANQKPA
VNGNRLTINNVLLRDIRIQAVQTSDFIQPGKAVDLVLVAVNQSPDVSDRLVGITSDIG
SVTVAGDARLPASGMLFVGTPDGQIVAPGPLPSNQAAKATVNLTKPIANGLTYNFTFK
FEKAGQGSVMVPISAGLATPHE"
gene 4026444..4027886
/gene="radA"
/locus_tag="Rv3585"
CDS 4026444..4027886
/codon_start=1
/transl_table=11
/gene="radA"
/locus_tag="Rv3585"
/product="DNA repair protein RadA (DNA repair protein
SMS)"
/note="Rv3585, (MTV024.03), len: 480 aa. Probable radA,
DNA repair protein (see citation below), similar to many
e.g. Q9X8L5|SCE94.02 from Streptomyces coelicolor (469
aa),FASTA scores: opt: 1607, E(): 3.1e-84, (56.15%
identity in 454 aa overlap); Q9JV51|RADA|NMA0992 from
Neisseria meningitidis (serogroup A) (459 aa), FASTA
scores: opt: 1275, E(): 2.5e-65, (45.0% identity in 458 aa
overlap); and Q9K040|RADA|NMB0782 from Neisseria
meningitidis (serogroup B) (459 aa), FASTA scores: opt:
1269, E(): 5.4e-65, (44.5% identity in 456 aa overlap);
P37572|RADA_BACSU|SMS from Bacillus subtilis (458 aa),
FASTA scores: opt: 1204, E(): 2.7e-61, (39.55% identity in
455 aa overlap); etc. Contains PS00017 ATP/GTP-binding
site motif A (P-loop). Belongs to the RadA family."
/db_xref="EnsemblGenomes-Gn:Rv3585"
/db_xref="EnsemblGenomes-Tr:CCP46408"
/db_xref="GOA:P9WHJ9"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004504"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR020588"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041166"
/db_xref="UniProtKB/Swiss-Prot:P9WHJ9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46408.1"
/translation="MANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGG
TRRRSVAPASGAVPISAVDAHRTRPCPTGIDELDRVLGGGIVPGSVTLLAGDPGVGKS
TLLLEVAHRWAQSGRRALYVSGEESAGQIRLRADRIGCGTEVEEIYLAAQSDVHTVLD
QIETVQPALVIVDSVQTMSTSEADGVTGGVTQVRAVTAALTAAAKANEVALILVGHVT
KDGAIAGPRSLEHLVDVVLHFEGDRNGALRMVRGVKNRFGAADEVGCFLLHDNGIDGI
VDPSNLFLDQRPTPVAGTAITVTLDGKRPLVGEVQALLATPCGGSPRRAVSGIHQARA
AMIAAVLEKHARLAIAVNDIYLSTVGGMRLTEPSADLAVAIALASAYANLPLPTTAVM
IGEVGLAGDIRRVNGMARRLSEAARQGFTIALVPPSDDPVPPGMHALRASTIVAALQY
MVDIADHRGTTLATPPSHSGTGHVPLGRGT"
gene 4027891..4028967
/locus_tag="Rv3586"
CDS 4027891..4028967
/codon_start=1
/transl_table=11
/locus_tag="Rv3586"
/product="Conserved hypothetical protein"
/note="Rv3586, (MTV024.04), len: 358 aa. Conserved
hypothetical protein, highly similar to Q9X8L6|SCE94.03
putative DNA-binding protein from Streptomyces coelicolor
(374 aa), FASTA scores: opt: 1338, E(): 5e-75, (59.95%
identity in 347 aa overlap); P37573|YACK_BACSU
hypothetical 40.7 KDA protein from Bacillus subtilis (360
aa), FASTA scores: opt: 875, E(): 1.4e-46, (42.15%
identity in 344 aa overlap); Q9KGG0|BH0105 hypothetical
protein from Bacillus halodurans (357 aa), FASTA scores:
opt: 844, E(): 1.1e-44,(40.3% identity in 350 aa overlap);
Q9WY43|TM0200 conserved hypothetical protein from
Thermotoga maritima (357 aa),FASTA scores: opt: 735, E():
5.7e-38, (39.4% identity in 353 aa overlap). Also some
similarity with other proteins. Contains probable
coiled-coil from 144 to 179."
/db_xref="EnsemblGenomes-Gn:Rv3586"
/db_xref="EnsemblGenomes-Tr:CCP46409"
/db_xref="GOA:P9WNW5"
/db_xref="InterPro:IPR003390"
/db_xref="InterPro:IPR010994"
/db_xref="InterPro:IPR018906"
/db_xref="InterPro:IPR023763"
/db_xref="InterPro:IPR036888"
/db_xref="InterPro:IPR038331"
/db_xref="InterPro:IPR041663"
/db_xref="UniProtKB/Swiss-Prot:P9WNW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46409.1"
/translation="MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDE
NVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDES
GTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLER
YKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLR
LQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVF
GYPTTTEAQDSTLSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDG
IGAMWARHVREGLSQLAESTISDQ"
gene complement(4028968..4029762)
/locus_tag="Rv3587c"
CDS complement(4028968..4029762)
/codon_start=1
/transl_table=11
/locus_tag="Rv3587c"
/product="Probable conserved membrane protein"
/note="Rv3587c, (MTV024.05c), len: 264 aa. Probable
conserved membrane protein, equivalent to Q9CBJ2|ML1918
hypothetical membrane protein from Mycobacterium leprae
(263 aa), FASTA scores: opt: 1438, E(): 2.4e-57, (77.55%
identity in 267 aa overlap). Contains hydrophobic stretch
in N-terminus; possible signal sequence. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3587c"
/db_xref="EnsemblGenomes-Tr:CCP46410"
/db_xref="GOA:O53572"
/db_xref="UniProtKB/TrEMBL:O53572"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46410.1"
/translation="MLDLEPRGPLPTEIYWRRRGLALGIAVVVVGIAVAIVIAFVDSS
AGAKPVSADKPASAQSHPGSPAPQAPQPAGQTEGNAAAAPPQGQNPETPTPTAAVQPP
PVLKEGDDCPDSTLAVKGLTNAPQYYVGDQPKFTMVVTNIGLVSCKRDVGAAVLAAYV
YSLDNKRLWSNLDCAPSNETLVKTFSPGEQVTTAVTWTGMGSAPRCPLPRPAIGPGTY
NLVVQLGNLRSLPVPFILNQPPPPPGPVPAPGPAQAPPPESPAQGG"
gene complement(4029871..4030494)
/gene="canB"
/locus_tag="Rv3588c"
CDS complement(4029871..4030494)
/codon_start=1
/transl_table=11
/gene="canB"
/locus_tag="Rv3588c"
/product="Beta-carbonic anhydrase CanB"
/note="Rv3588c, (MTV024.06c), len: 207 aa.
CanB,Beta-carbonic anhydrase, proven biochemically (See
Suarez Covarrubias et al. 2005) similar to others e.g.
Q9CBJ1|ML1919 putative carbonic anhydrase from
Mycobacterium leprae (213 aa), FASTA scores: opt:
1160,E(): 3.1e-66, (84.55% identity in 207 aa overlap).
Also similar to many e.g. Q9X903|SCH35.03 from
Streptomyces coelicolor (207 aa), FASTA scores: opt: 689,
E(): 1.6e-36,(53.85% identity in 195 aa overlap);
Q9RS89|DR2238 from Deinococcus radiodurans (264 aa), FASTA
scores: opt: 451,E(): 2e-21, (39.7% identity in 189 aa
overlap); Q39589|beta-CA1 from Chlamydomonas reinhardtii
(267 aa) FASTA scores: opt: 419, E(): 2.1e-19, (36.55%
identity in 197 aa overlap); etc. Contains PS00704 and
PS00705 Prokaryotic-type carbonic anhydrases signature 1
and 2. Belongs to the plant and prokaryotic carbonic
anhydrase family."
/db_xref="EnsemblGenomes-Gn:Rv3588c"
/db_xref="EnsemblGenomes-Tr:CCP46411"
/db_xref="GOA:P9WPJ9"
/db_xref="InterPro:IPR001765"
/db_xref="InterPro:IPR015892"
/db_xref="InterPro:IPR036874"
/db_xref="PDB:1YM3"
/db_xref="PDB:2A5V"
/db_xref="UniProtKB/Swiss-Prot:P9WPJ9"
/inference="protein motif:PROSITE:PS00705"
/inference="protein motif:PROSITE:PS00704"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46411.1"
/translation="MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKP
TAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVL
GHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHET
VAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV"
gene 4030493..4031407
/gene="mutY"
/locus_tag="Rv3589"
CDS 4030493..4031407
/codon_start=1
/transl_table=11
/gene="mutY"
/locus_tag="Rv3589"
/product="Probable adenine glycosylase MutY"
/note="Rv3589, (MTV024.07), len: 304 aa. Probable
mutY,adenine glycosylase (see citation below), equivalent
to Q9CBJ0|MUTY|ML1920 probable DNA glycosylase from
Mycobacterium leprae (297 aa), FASTA scores: opt:
1592,E(): 2.6e-94, (74.9% identity in 303 aa overlap).
Also similar to many DNA glycosylases (generally adenine
glycosylases) e.g. Q9S6T7|SCE94.06 from Streptomyces
coelicolor (308 aa), FASTA scores: opt: 965, E():
2.6e-54,(50.5% identity in 297 aa overlap); Q9S6G1|MUTY
from Streptomyces antibioticus (307 aa), FASTA scores:
opt: 901,E(): 3.1e-50, (48.5% identity in 303 aa overlap);
Q9HPQ6|MUTY|VNG1520G from Halobacterium sp. strain NRC-1
(312 aa), FASTA scores: opt: 566, E(): 7.2e-29, (39.85%
identity in 296 aa overlap); BAB53965|MLL7523 from
Rhizobium loti (Mesorhizobium loti) (396 aa), FASTA
scores: opt: 511, E(): 2.8e-25, (39.65% identity in 237 aa
overlap); Q05869|MUTY_SALTY|MUTB from Salmonella
typhimurium (350 aa), FASTA scores: opt: 421, E():
3.8e-20,(35.2% identity in 227 aa overlap); etc. Could
belong to the nth/MUTY family."
/db_xref="EnsemblGenomes-Gn:Rv3589"
/db_xref="EnsemblGenomes-Tr:CCP46412"
/db_xref="GOA:P9WQ09"
/db_xref="InterPro:IPR000445"
/db_xref="InterPro:IPR003265"
/db_xref="InterPro:IPR003651"
/db_xref="InterPro:IPR011257"
/db_xref="InterPro:IPR023170"
/db_xref="UniProtKB/Swiss-Prot:P9WQ09"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46412.1"
/translation="MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQI
LVSEFMLQQTPAARVLAIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRLHE
CATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAV
HGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWC
AWRHAGYPPSDGPPRRGQAYTGTDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQR
DRALESLLADALVTRTVDGRFALPGEGF"
gene complement(4031404..4033158)
/gene="PE_PGRS58"
/locus_tag="Rv3590c"
CDS complement(4031404..4033158)
/codon_start=1
/transl_table=11
/gene="PE_PGRS58"
/locus_tag="Rv3590c"
/product="PE-PGRS family protein PE_PGRS58"
/note="Rv3590c, (MTV024.08c, MTCY6F7.04), len: 584 aa.
PE_PGRS58, Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below), highly similar to e.g. O53439|Rv1091|MTV017.44
(853 aa), FASTA scores: opt: 2005, E(): 1.4e-70, (54.95%
identity in 646 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3590c"
/db_xref="EnsemblGenomes-Tr:CCP46413"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:I6XHM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46413.1"
/translation="MSFVIVAPEALMSVASEVAGIGSALNAANAAAAAPTTGVLAAAA
DEVSAAMAALFGAHAQEYQRLSAQAAGFHAQFVQALNAGVNSYASAEAANASPLQAVE
QQVLGLINGPAQTLLGRPLIGNGADGAPGTGQPGGPGGLLWGNGGNGGSGVAGVGGPG
GSGGAAGLFGHGGNGGAGGSNAAGAGGVGGAGGAGWLVGNGGAGGFGGVGTTVSGNGG
AGGAAGAFGNGGVGGAGGAAVIGGLPGNGGAGGNAGLIGAGGDGGVGGVGAPGTNGMN
PPPNQTSQAANGSPGANNGAGSGGAGLPGNPGAVPGRAGGAGGLGGSGSDTSEGPVTG
GNGGNGGDGGPGAPGGNGAPGGIGVNTGTGWAYGGNGGNGGDGGAGARGGDGGNGGNG
LALNGGNGIGGNGGAGGRGGTGAAGGNGGIGGGATGTLTFFGSGGDGGPGGAGANTAG
TGGVGGVGGAGGQGGLLFGDGGNGGAGGAGGIGGTGASGGAGGKGGSGLVGGDGGNGG
AGGAGGNGGKGGAGGAGGGAGMFSQPGVHGAGGTGGQGGAGGAGGAGGAAGAGTVVAG
NPGDPGGFGAAGADGLPG"
gene complement(4033269..4034042)
/locus_tag="Rv3591c"
CDS complement(4033269..4034042)
/codon_start=1
/transl_table=11
/locus_tag="Rv3591c"
/product="Possible hydrolase"
/note="Rv3591c, (MTCY6F7.03), len: 257 aa. Possible
hydrolase, equivalent to Q9CBI9|ML1921 hypothetical
protein from Mycobacterium leprae (256 aa) FASTA scores:
opt: 1421,E(): 5.6e-83, (78.5% identity in 251 aa
overlap). Also similar to others e.g. Q9K3V0|SCD10.27
putative hydrolase from Streptomyces coelicolor (352 aa),
FASTA scores: opt: 193, E(): 5.2e-05, (33.35% identity in
270 aa overlap); O33745|STTC thioesterase from
Streptomyces sp (308 aa) FASTA scores: opt: 242, E():
3.6e-08, (30.35% identity in 270 aa overlap);
Q9RK95|SCF1.09 putative hydrolase from Streptomyces
coelicolor (258 aa), FASTA scores: opt: 239,E(): 4.9e-08,
(30.75% identity in 247 aa overlap); Q9HZ14|PA3226
probable hydrolase from Pseudomonas aeruginosa (275 aa),
FASTA scores: opt: 226, E(): 3.4e-07,(26.6% identity in
252 aa overlap); Q9HPT9|est|VNG1474G carboxylesterase from
Halobacterium sp. strain NRC-1 (274 aa), FASTA scores:
opt: 215, E(): 1.7e-06, (26.95% identity in 256 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3591c"
/db_xref="EnsemblGenomes-Tr:CCP46414"
/db_xref="GOA:I6YGL1"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6YGL1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46414.1"
/translation="MPRMPANLLTHRGGRGEPLVLVHGLMGRGSTWARQLPWLTLLGA
VYTYDAPWHRGRDVADPHPISTERFVADLGDAVSALGAPTRMVGHSMGALHSWCLAAE
RPELVSALVVEDMAPDFRGRTTGPWEPWLRALPVEFDSAEQVFAEFGPVAGRYFLDAF
DRTATGWRLHGRTARWIEIAAEWGTRDYWAQWRAVRSPALLIEAGDGVTPPGQMRAMA
ERDYPTAYLRVPDAGHLVHDEAPQVYRRAVESFLAGLTP"
gene 4034057..4034374
/gene="mhuD"
/gene_synonym="TB11.2"
/locus_tag="Rv3592"
CDS 4034057..4034374
/codon_start=1
/transl_table=11
/gene="mhuD"
/gene_synonym="TB11.2"
/locus_tag="Rv3592"
/product="Possible heme degrading protein MhuD"
/note="Rv3592, (MTCY6F7.02c), len: 105 aa. Possible
mhuD,heme-degrading protein, equivalent to Q9CBI8|ML1922
hypothetical protein from Mycobacterium leprae (105 aa)
FASTA scores: opt: 591, E(): 2.5e-34, (84.6% identity in
104 aa overlap). Shows some similarity with other
bacterial hypothetical proteins e.g. Q9RXN8|DR0272 from
Deinococcus radiodurans (109 aa), FASTA scores: opt: 178,
E(): 1e-05,(34.3% identity in 102 aa overlap);
P38049|YHGC_BACSU from Bacillus subtilis (166 aa) FASTA
scores: opt: 175, E(): 2.4e-05, (40.85% identity in 71 aa
overlap); Q9K649|BH3883 from Bacillus halodurans (102 aa)
FASTA scores: opt: 162,E(): 0.00012, (33.75% identity in
80 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3592"
/db_xref="EnsemblGenomes-Tr:CCP46415"
/db_xref="GOA:P9WKH3"
/db_xref="InterPro:IPR007138"
/db_xref="InterPro:IPR011008"
/db_xref="PDB:3HX9"
/db_xref="PDB:4NL5"
/db_xref="PDB:5UQ4"
/db_xref="PDB:6DS7"
/db_xref="PDB:6DS8"
/db_xref="UniProtKB/Swiss-Prot:P9WKH3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46415.1"
/translation="MPVVKINAIEVPAGAGPELEKRFAHRAHAVENSPGFLGFQLLRP
VKGEERYFVVTHWESDEAFQAWANGPAIAAHAGHRANPVATGASLLEFEVVLDVGGTG
KTA"
gene 4034352..4035710
/gene="lpqF"
/locus_tag="Rv3593"
CDS 4034352..4035710
/codon_start=1
/transl_table=11
/gene="lpqF"
/locus_tag="Rv3593"
/product="Probable conserved lipoprotein LpqF"
/note="Rv3593, (MTCY6F7.01c), len: 452 aa. Probable
lpqF,conserved lipoprotein, equivalent to
Q9CBI7|MPQF|ML1923 probale secreted protein from
Mycobacterium leprae (454 aa), FASTA scores: opt: 2465,
E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also
similar to Q9KJ91 hypothetical 47.1 KDA protein from
Streptomyces clavuligerus (430 aa), FASTA scores: opt:
609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and
some similarity with putative beta-lactamases e.g.
Q9RYR7|DRA0241 beta lactamase-related protein from
Deinococcus radiodurans (499 aa), FASTA scores: opt:
322,E(): 2.5e-12, (28.25% identity in 322 aa overlap).
Equivalent to AAK48057 from Mycobacterium tuberculosis
strain CDC1551 (438 aa) but longer 14 aa. Contains
N-terminal signal sequence and appropriately positioned
PS00013 Prokaryotic membrane lipoprotein lipid attachment
site."
/db_xref="EnsemblGenomes-Gn:Rv3593"
/db_xref="EnsemblGenomes-Tr:CCP46416"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR040846"
/db_xref="UniProtKB/TrEMBL:O06155"
/inference="protein motif:PROSITE:PS00013"
/protein_id="CCP46416.1"
/translation="MGPARLHNRRAGRRMLALSAAAALIVALASGCSSAPTPSANAAN
HGHRIDTRTPPGLRAQQTMDMLNSDWPIGEIGVGTLAAPGQVDTVKTTMEALWWDRPF
ALAGVDIGASVAALHLISSYGAQQDIRIHTDDDGWVDRFDVETQAPSIASWRDVDAAL
SKTGARYSFQVAKVDNGRCDPVAGTNTGESLPLASIFKLYVLHALAGAVQHNTVSWDD
LLTVTAKSKAVGSSGLELPVGARVSVRTAAEKMIATSDNMATDLLIERLGTRAIEEAL
ASAGHHDPASMTPFPTMYELFSVGWGKPDLRDQWKHATQQVRAQILRQTNSTPYQPDP
TRAHTPASNYGAEWYGSAEDICRVHAALRADAVGPASPVRQIMSAVPGIQLDRSVWPY
IGAKAGGLPGDLTFSWYAVDKTGQPWVVSFQLNWPRDHGPTVTGWMLQVARQVFALIA
PQ"
gene 4035857..4036684
/locus_tag="Rv3594"
CDS 4035857..4036684
/codon_start=1
/transl_table=11
/locus_tag="Rv3594"
/product="Conserved hypothetical protein"
/note="Rv3594, (MTCY07H7B.28c), len: 275 aa. Hypothetical
protein, highly similar in part with Q9ZX49|GP29 from
Mycobacteriophage TM4 (547 aa), FASTA scores: opt:
526,E(): 1.3e-25, (46.25% identity in 186 aa overlap); and
Q9FZS0|LYSA|GP2 from Mycobacterium phage Ms6 (384 aa)
FASTA scores: opt: 147, E(): 0.064, (33.35% identity in 84
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3594"
/db_xref="EnsemblGenomes-Tr:CCP46417"
/db_xref="GOA:I6Y3Z2"
/db_xref="InterPro:IPR002502"
/db_xref="InterPro:IPR036505"
/db_xref="UniProtKB/TrEMBL:I6Y3Z2"
/protein_id="CCP46417.1"
/translation="MGWIGDPIWLEEVLRPALGERLRVLDGWRERGHGDFRDIRGVMW
HHTGNSRETAKSIARGRPDLPGPLANLHIAHSGVVTIVAVGVCWHAGRGSYPWLPTDN
ANWHMIGVECAWPTIRRDGSYDAGERWPDAQIVSMRDVAAALTLKLGYGPERNIGHKE
YAGAAQGKWDPGNLSMDWFRAEVAKDTRGEFDHPLTPPPAVIARPPILPKPRNPRDDR
ILLEEVWDQLRGIEGRGWPVLGDKTIVDYLAELGNKVDALAAKLDAREGLDRPSDTR"
gene complement(4036731..4038050)
/gene="PE_PGRS59"
/locus_tag="Rv3595c"
CDS complement(4036731..4038050)
/codon_start=1
/transl_table=11
/gene="PE_PGRS59"
/locus_tag="Rv3595c"
/product="PE-PGRS family protein PE_PGRS59"
/note="Rv3595c, (MTCY07H7B.27), len: 439 aa.
PE_PGRS59,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citation
below),similar to many e.g. O53439|Rv1091|MTV017.44 (853
aa),FASTA scores: opt: 1644, E(): 1.2e-57, (58.75%
identity in 492 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3595c"
/db_xref="EnsemblGenomes-Tr:CCP46418"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q6MWV6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46418.1"
/translation="MSFVIAVPEFLSAAATDLANLGSTISAANAAASIPTTGVLAAGA
DDVSAAIAALFGAHAQAYQTISAQAATFHAQFVQTLSAGAGAYANAEAANVQQSLLNA
INAPTQALLGRPLIGDGADGTAPGQNGGAGGLLYGNGGNGAAGVNAGIAGGSGGAAGL
IGNGGSGGAGGAGAAGGSGGQGGLLYGNGGAGGNGGAATIPGGNGGAGGAGGNAWLFG
NGGAGGLGAAGAAGAAGVNPLTVPAGQGSMGNNGEPGGPGQPGTEFGQTGGTGGTGGT
GLSVGGTGGTGGTGGTGGAGGSGGRGGLLVGDGGAGGIGGTGGEGGIGARGGTGGQGG
MGGAGQPGVGGDAGDGGNGGIGGDGGAGGDGGAGGAGGAGGLFGVSGSSGLGGAAGSG
GNGGGGGEPGVAGSPGVGPAGRGGDGNLGQFGPEGAPGQPGQPGQPG"
gene complement(4038158..4040704)
/gene="clpC1"
/gene_synonym="clpC"
/locus_tag="Rv3596c"
CDS complement(4038158..4040704)
/codon_start=1
/transl_table=11
/gene="clpC1"
/gene_synonym="clpC"
/locus_tag="Rv3596c"
/product="Probable ATP-dependent protease ATP-binding
subunit ClpC1"
/note="Rv3596c, (MTCY07H7B.26), len: 848 aa. Probable
clpC1, ATP-dependent protease ATP-binding
subunit,equivalent to P24428|CLPC_MYCLE probable
ATP-dependent CLP protease ATP-binding subunit from
Mycobacterium leprae (848 aa) (see Misra et al., 1996),
FASTA scores: opt: 5286, E(): 0, (97.15% identity in 845
aa overlap). Also highly similar to members of the
clpA/clpB family e.g. Q9S6T8|SCE94.24c from Streptomyces
coelicolor (841 aa) FASTA scores: opt: 4399, E(): 0,
(81.0% identity in 848 aa overlap); Q9KGG2|CLPC|BH0103
from Bacillus halodurans (813 aa), FASTA scores: opt:
3279, E(): 3.8e-173, (61.9% identity in 808 aa overlap);
Q55662|CLPC|SLL0020 from Synechocystis sp. strain PCC 6803
(821 aa), FASTA scores: opt: 3201, E(): 7.6e-169,(60.5%
identity in 820 aa overlap); P51332|CLPC_PORPU from
Porphyra purpurea (821 aa), FASTA scores: opt: 3045, E():
3e-160, (57.65% identity in 817 aa overlap);
P37571|CLPC_BACSU|MECB from Bacillus subtilis (810
aa),FASTA scores: opt: 2969, E(): 4.6e-156, (61.15%
identity in 811 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop). Note that
previously known as clpC. Belongs to the CLPA/CLPB family,
CLPC subfamily. Conserved in M. tuberculosis, M. leprae,
M. bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3596c"
/db_xref="EnsemblGenomes-Tr:CCP46419"
/db_xref="GOA:P9WPC9"
/db_xref="InterPro:IPR001270"
/db_xref="InterPro:IPR001943"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR004176"
/db_xref="InterPro:IPR018368"
/db_xref="InterPro:IPR019489"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036628"
/db_xref="InterPro:IPR041546"
/db_xref="PDB:3WDB"
/db_xref="PDB:3WDC"
/db_xref="PDB:3WDD"
/db_xref="PDB:3WDE"
/db_xref="PDB:6CN8"
/db_xref="UniProtKB/Swiss-Prot:P9WPC9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46419.1"
/translation="MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGV
AAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNY
IGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGG
ESGSPSTSLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEP
GVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEI
NTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEK
DAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDAAMVAAATLADRYIND
RFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASL
RDREKTLVAQRAEREKQWRSGDLDVVAEVDDEQIAEVLGNWTGIPVFKLTEAETTRLL
RMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKAL
ANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLF
DEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFS
KGGGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFHQLTREEIIRMVDLMISRVAG
QLKSKDMALVLTDAAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQ
VVTVDVDNWDGEGPGEDAVFTFTGTRKPPAEPDLAKAGAHSAGGPEPAAR"
gene 4040879..4040938
/gene="mpr17"
ncRNA 4040879..4040938
/gene="mpr17"
/product="Fragment of putative small regulatory RNA"
/note="mpr17, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), ends not mapped, 82-118 nt
bands detected by Northern blot in M. bovis BCG Pasteur."
/ncRNA_class="other"
gene complement(4040981..4041319)
/gene="lsr2"
/locus_tag="Rv3597c"
CDS complement(4040981..4041319)
/codon_start=1
/transl_table=11
/gene="lsr2"
/locus_tag="Rv3597c"
/product="Iron-regulated H-NS-like protein Lsr2"
/note="Rv3597c, (MTCY07H7B.25), len: 112 aa.
Lsr2,H-NS-like protein, identical to
P24094|LSR2_MYCLE|ML0234 LSR2 protein precursor (15 KDA
antigen) (A15) from Mycobacterium leprae (112 aa), FASTA
scores: opt: 698, E(): 6.7e-37, (92.85% identity in 112 aa
overlap). Also highly similar to others e.g.
Q9X8N1|SCE94.26c from Streptomyces coelicolor (111 aa),
FASTA scores: opt: 379, E(): 4.4e-17,(58.05% identity in
112 aa overlap); Q9ETI2|LSR2 from Corynebacterium equii
(Rhodococcus equi) (119 aa), FASTA scores: opt: 328, E():
6.9e-14, (47.5% identity in 120 aa overlap); and
Q9RKK8|SCD25.12c from Streptomyces coelicolor (105 aa),
FASTA scores: opt: 293, E(): 9.4e-12, (47.75% identity in
111 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3597c"
/db_xref="EnsemblGenomes-Tr:CCP46420"
/db_xref="GOA:P9WIP7"
/db_xref="InterPro:IPR024412"
/db_xref="InterPro:IPR042254"
/db_xref="InterPro:IPR042261"
/db_xref="PDB:2KNG"
/db_xref="PDB:4E1P"
/db_xref="PDB:4E1R"
/db_xref="PDB:6QKP"
/db_xref="PDB:6QKQ"
/db_xref="UniProtKB/Swiss-Prot:P9WIP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46420.1"
/translation="MAKKVTVTLVDDFDGSGAADETVEFGLDGVTYEIDLSTKNATKL
RGDLKQWVAAGRRVGGRRRGRSGSGRGRGAIDREQSAAIREWARRNGHNVSTRGRIPA
DVIDAYHAAT"
gene complement(4041423..4042940)
/gene="lysS"
/locus_tag="Rv3598c"
CDS complement(4041423..4042940)
/codon_start=1
/transl_table=11
/gene="lysS"
/locus_tag="Rv3598c"
/product="Lysyl-tRNA synthetase 1 LysS (lysine--tRNA
ligase 1) (LysRS 1) (lysine translase)"
/note="Rv3598c, (MTCY07H7B.24), len: 505 aa. Probable
lysS,lysyl-tRNA synthetase 1, equivalent to
P46861|SYK_MYCLE|LYSS|ML0233 lysyl-tRNA synthetase from
Mycobacterium leprae (507 aa), FASTA scores: opt:
2835,E(): 4.5e-172, (85.45% identity in 501 aa overlap);
and similar with C-terminal part of Q9CC23|LYSX|ML1393
C-term lysyl-tRNA synthase from Mycobacterium leprae (1039
aa) FASTA scores: opt: 1257, E(): 7.6e-72, (44.55%
identity in 505 aa overlap). Also similar to others e.g.
P37477|SYK_BACSU|LYSS from Bacillus subtilis (499 aa)
FASTA scores: opt: 1294, E(): 1.9e-74, (42.35% identity in
498 aa overlap); Q9RHV9|SYK_BACST|LYSS from Bacillus
stearothermophilus (494 aa), FASTA scores: opt: 1258, E():
3.5e-72, (41.15% identity in 498 aa overlap);
Q9PEB6|SYK_XYLFA|LYSS|XF1112 from Xylella fastidiosa (506
aa), FASTA scores: opt: 1228, E(): 2.9e-70, (43.05%
identity in 495 aa overlap); etc. Also similar to
P94974|SYK2_MYCTU|LYSS2|LYSX|Rv1640c|MTCY06H11.04c
lysyl-tRNA synthetase 2 from Mycobacterium tuberculosis
(1172 aa), FASTA scores: opt: 1295, E(): 3.3e-74, (45.65%
identity in 506 aa overlap). Contains PS00179
Aminoacyl-transfer RNA synthetases class-II signature 1.
Belongs to class-II aminoacyl-tRNA synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv3598c"
/db_xref="EnsemblGenomes-Tr:CCP46421"
/db_xref="GOA:P9WFU9"
/db_xref="InterPro:IPR002313"
/db_xref="InterPro:IPR004364"
/db_xref="InterPro:IPR004365"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR018149"
/db_xref="UniProtKB/Swiss-Prot:P9WFU9"
/inference="protein motif:PROSITE:PS00179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46421.1"
/translation="MSAADTAEDLPEQFRIRRDKRARLLAQGRDPYPVAVPRTHTLAE
VRAAHPDLPIDTATEDIVGVAGRVIFARNSGKLCFATLQDGDGTQLQVMISLDKVGQA
ALDAWKADVDLGDIVYVHGAVISSRRGELSVLADCWRIAAKSLRPLPVAHKEMSEESR
VRQRYVDLIVRPEARAVARLRIAVVRAIRTALQRRGFLEVETPVLQTLAGGAAARPFA
THSNALDIDLYLRIAPELFLKRCIVGGFDKVFELNRVFRNEGADSTHSPEFSMLETYQ
TYGTYDDSAVVTRELIQEVADEAIGTRQLPLPDGSVYDIDGEWATIQMYPSLSVALGE
EITPQTTVDRLRGIADSLGLEKDPAIHDNRGFGHGKLIEELWERTVGKSLSAPTFVKD
FPVQTTPLTRQHRSIPGVTEKWDLYLRGIELATGYSELSDPVVQRERFADQARAAAAG
DDEAMVLDEDFLAALEYGMPPCTGTGMGIDRLLMSLTGLSIRETVLFPIVRPHSN"
gene complement(4042952..4043035)
/locus_tag="Rv3599c"
CDS complement(4042952..4043035)
/codon_start=1
/transl_table=11
/locus_tag="Rv3599c"
/product="Hypothetical short protein"
/note="Rv3599c, (MTCY07H7B.23), len: 27 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3599c"
/db_xref="EnsemblGenomes-Tr:CCP46422"
/db_xref="UniProtKB/TrEMBL:O06283"
/protein_id="CCP46422.1"
/translation="MPASSLGTGSPAADRLDATHERRREVI"
gene complement(4043041..4043859)
/locus_tag="Rv3600c"
CDS complement(4043041..4043859)
/codon_start=1
/transl_table=11
/locus_tag="Rv3600c"
/product="Conserved protein"
/note="Rv3600c, (MTCY07H7B.22), len: 272 aa. Conserved
protein, identical to Q9CD56|ML0232 hypothetical protein
from Mycobacterium leprae (274 aa), FASTA scores: opt:
1585, E(): 1.3e-92, (90.5% identity in 274 aa overlap).
Also highly similar to others e.g. Q9X8N6|SCE94.31c from
Streptomyces coelicolor (265 aa) FASTA scores: opt:
878,E(): 3.9e-48, (51.5% identity in 268 aa overlap); and
Q9KGH5|BH0086 from Bacillus halodurans (254 aa), FASTA
scores: opt: 611, E(): 2.4e-31, (37.5% identity in 264 aa
overlap). And similar to various bacterial proteins e.g.
Q9F985 putative 32 KDA replication protein from Bacillus
stearothermophilus (258 aa), FASTA scores: opt: 594, E():
2.8e-30, (37.45% identity in 267 aa overlap);
P37564|YACB_BACSU from Bacillus subtilis (233 aa), FASTA
scores: opt: 522, E(): 8.8e-26, (38.95% identity in 213 aa
overlap); Q9RX54|DR0461 conserved hypothetical protein
from Deinococcus radiodurans (262 aa), FASTA scores: opt:
503,E(): 1.5e-24, (38.45% identity in 268 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3600c"
/db_xref="EnsemblGenomes-Tr:CCP46423"
/db_xref="GOA:P9WPA1"
/db_xref="InterPro:IPR004619"
/db_xref="UniProtKB/Swiss-Prot:P9WPA1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46423.1"
/translation="MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELA
LTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLV
DNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSS
DAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSV
DHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR"
gene complement(4043862..4044281)
/gene="panD"
/locus_tag="Rv3601c"
CDS complement(4043862..4044281)
/codon_start=1
/transl_table=11
/gene="panD"
/locus_tag="Rv3601c"
/product="Probable aspartate 1-decarboxylase precursor
PanD (aspartate alpha-decarboxylase)"
/note="Rv3601c, (MTCY07H7B.21), len: 139 aa. Probable
panD,aspartate 1-decarboxylase, identical to
Q9CD57|PAND|ML0231 putative aspartate-1-decarboxylase from
Mycobacterium leprae (142 aa), FASTA scores: opt: 733,
E(): 5.5e-41,(82.85% identity in 140 aa overlap). Also
highly similar to many e.g. CAC44328|PAND from
Streptomyces coelicolor (139 aa), FASTA scores: opt: 578,
E(): 6.4e-31, (75.0% identity in 120 aa overlap);
Q9X4N0|PAND from Corynebacterium glutamicum
(Brevibacterium flavum) (136 aa), FASTA scores: opt: 506,
E(): 3e-26, (62.2% identity in 135 aa overlap);
P52999|PAND_BACSU from Bacillus subtilis (127 aa) FASTA
scores: opt: 421, E(): 9.6e-21, (54.75% identity in 123 aa
overlap); P31664|PAND_ECOLI|B0131 from Escherichia coli
strain K12 (126 aa), FASTA scores: opt: 388, E():
1.3e-18,(50.45% identity in 113 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3601c"
/db_xref="EnsemblGenomes-Tr:CCP46424"
/db_xref="GOA:P9WIL3"
/db_xref="InterPro:IPR003190"
/db_xref="InterPro:IPR009010"
/db_xref="PDB:2C45"
/db_xref="UniProtKB/Swiss-Prot:P9WIL3"
/protein_id="CCP46424.1"
/translation="MLRTMLKSKIHRATVTCADLHYVGSVTIDADLMDAADLLEGEQV
TIVDIDNGARLVTYAITGERGSGVIGINGAAAHLVHPGDLVILIAYATMDDARARTYQ
PRIVFVDAYNKPIDMGHDPAFVPENAGELLDPRLGVG"
gene complement(4044281..4045210)
/gene="panC"
/locus_tag="Rv3602c"
CDS complement(4044281..4045210)
/codon_start=1
/transl_table=11
/gene="panC"
/locus_tag="Rv3602c"
/product="Pantoate--beta-alanine ligase PanC (pantothenate
synthetase) (pantoate activating enzyme)"
/note="Rv3602c, (MTCY07H7B.20), len: 309 aa.
panC,pantoate--beta-alanine ligase, equivalent to
O69524|PANC_MYCLE|ML0230|MLCB2548.01c
pantoate--beta-alanine ligase from Mycobacterium leprae
(313 aa), FASTA scores: opt: 1541, E(): 3.4e-84, (82.15%
identity in 297 aa overlap). Also similar to others e.g.
O67891|PANC_AQUAE|AQ_2132 from Aquifex aeolicus (282 aa)
FASTA scores: opt: 774, E(): 8.6e-39, (46.9% identity in
273 aa overlap); Q9HV69|PANC_PSEAE|PA4730 from Pseudomonas
aeruginosa (283 aa), FASTA scores: opt: 770, E():
1.5e-38,(51.45% identity in 276 aa overlap); Q9A6C8|CC2166
from Caulobacter crescentus (285 aa), FASTA scores: opt:
744,E(): 5.2e-37, (47.75% identity in 268 aa overlap);
P31663|PANC_ECOLI|B0133 from Escherichia coli strain K12
(283 aa), FASTA scores: opt: 695, E(): 4.1e-34, (46.1%
identity in 271 aa overlap); etc. Belongs to the
pantothenate synthetase family."
/db_xref="EnsemblGenomes-Gn:Rv3602c"
/db_xref="EnsemblGenomes-Tr:CCP46425"
/db_xref="GOA:P9WIL5"
/db_xref="InterPro:IPR003721"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR042176"
/db_xref="PDB:1MOP"
/db_xref="PDB:1N2B"
/db_xref="PDB:1N2E"
/db_xref="PDB:1N2G"
/db_xref="PDB:1N2H"
/db_xref="PDB:1N2I"
/db_xref="PDB:1N2J"
/db_xref="PDB:1N2O"
/db_xref="PDB:2A7X"
/db_xref="PDB:2A84"
/db_xref="PDB:2A86"
/db_xref="PDB:2A88"
/db_xref="PDB:3COV"
/db_xref="PDB:3COW"
/db_xref="PDB:3COY"
/db_xref="PDB:3COZ"
/db_xref="PDB:3IMC"
/db_xref="PDB:3IME"
/db_xref="PDB:3IMG"
/db_xref="PDB:3IOB"
/db_xref="PDB:3IOC"
/db_xref="PDB:3IOD"
/db_xref="PDB:3IOE"
/db_xref="PDB:3ISJ"
/db_xref="PDB:3IUB"
/db_xref="PDB:3IUE"
/db_xref="PDB:3IVC"
/db_xref="PDB:3IVG"
/db_xref="PDB:3IVX"
/db_xref="PDB:3LE8"
/db_xref="PDB:4DDH"
/db_xref="PDB:4DDK"
/db_xref="PDB:4DDM"
/db_xref="PDB:4DE5"
/db_xref="PDB:4EF6"
/db_xref="PDB:4EFK"
/db_xref="PDB:4FZJ"
/db_xref="PDB:4G5F"
/db_xref="PDB:4G5Y"
/db_xref="UniProtKB/Swiss-Prot:P9WIL5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46425.1"
/translation="MTIPAFHPGELNVYSAPGDVADVSRALRLTGRRVMLVPTMGALH
EGHLALVRAAKRVPGSVVVVSIFVNPMQFGAGEDLDAYPRTPDDDLAQLRAEGVEIAF
TPTTAAMYPDGLRTTVQPGPLAAELEGGPRPTHFAGVLTVVLKLLQIVRPDRVFFGEK
DYQQLVLIRQLVADFNLDVAVVGVPTVREADGLAMSSRNRYLDPAQRAAAVALSAALT
AAAHAATAGAQAALDAARAVLDAAPGVAVDYLELRDIGLGPMPLNGSGRLLVAARLGT
TRLLDNIAIEIGTFAGTDRPDGYRAILESHWRN"
gene complement(4045207..4046118)
/locus_tag="Rv3603c"
CDS complement(4045207..4046118)
/codon_start=1
/transl_table=11
/locus_tag="Rv3603c"
/product="Conserved hypothetical alanine and leucine rich
protein"
/note="Rv3603c, (MTCY07H7B.19), len: 303 aa. Conserved
hypothetical ala-, leu-rich protein, identical except at
N-terminus (really different) to AAK48066|MT3708
chalcone/stilbene synthase family protein from
Mycobacterium tuberculosis strain CDC1551 (361 aa) FASTA
scores: opt: 1742, E(): 8.3e-95, (100.0% identity in 275
aa overlap). Equivalent to O69525|MLCB2548.02c|ML0229
hypothetical 32.7 KDA protein from Mycobacterium leprae
(309 aa), FASTA scores: opt: 947, E(): 2.4e-48, (67.85%
identity in 311 aa overlap). Also highly similar to
Q9X845|SCE126.02c hypothetical 42.2 KDA protein from
Streptomyces coelicolor (420 aa), FASTA scores: opt:
683,E(): 8.5e-33, (49.3% identity in 284 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3603c"
/db_xref="EnsemblGenomes-Tr:CCP46426"
/db_xref="GOA:O06279"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR018931"
/db_xref="InterPro:IPR019665"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR037108"
/db_xref="UniProtKB/TrEMBL:O06279"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46426.1"
/translation="MERFDGLRPARLKVGIISAGRVGTALGVALQRADHVVVACSAIS
HASRRRAQRRLPDTPVLPPLDVAASAELLLLAVTDSELAGLVSGLAATSAVRPQTIVA
HTSGANGIGILAPLAQQGCIPLAIHPAMTFTGSDEDISRLPDTCFGITAADDVGYAIG
QSLVLEMGGEPFCVREDARILYHAALAHASNHIVTVLADALEALRAALSGGELLGQQT
VDDQPGGIVERIVGPLARAALENTLQRGQAALTGPVARGDAAAVADHLAALADVDAAL
AQAYRINALRTAQRAHAPADVVEVLTA"
gene complement(4046303..4047496)
/locus_tag="Rv3604c"
CDS complement(4046303..4047496)
/codon_start=1
/transl_table=11
/locus_tag="Rv3604c"
/product="Probable conserved transmembrane protein rich in
alanine and arginine and proline"
/note="Rv3604c, (MTCY07H7B.18), len: 397 aa. Probable
conserved ala-, arg-, pro-rich transmembrane
protein,equivalent to O69526|MLCB2548.03c|ML0228 putative
membrane protein from Mycobacterium leprae (432 aa), FASTA
scores: opt: 869, E(): 2.9e-31, (59.7% identity in 432 aa
overlap). Contains two possible membrane-spanning domains.
N-terminus shortened since first submission (previously
462 aa). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3604c"
/db_xref="EnsemblGenomes-Tr:CCP46427"
/db_xref="GOA:O06278"
/db_xref="UniProtKB/TrEMBL:O06278"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46427.1"
/translation="MTVLSRGARVRRGGRRPGWVLLTALLVLAIGASSALVFTDRVEL
LKLAVLLALWAAVAGAFVSVLYRRQSDVDQARVRDLKLVYDLQLDREISARREYELTL
ESQLRRELASELRAPAADEVAALRAELAALRTSLEILFDADLEHRPALGTVEKEARAA
RALDGESPPADWVSSDRVMAVRGGDGASRTDEASIIDVPEVGVPPVSGGPRHYEAPPP
PQPEPLFEPRHRPPPLPPQQERPVWQPVTSHGQWLPAETPGSQWASVEPETTPAAPPP
GRRRRARHASPADQAYNPPAYVELAAQYGESGRRSRHSAEHRDHDIGGSGAGTGERPP
SPPMAPPPPAEPTRRHRTADTPPDDSGGLHARDPLTGGQSVADLMARLQVESTGGGRR
RRRGE"
gene complement(4047705..4048181)
/locus_tag="Rv3605c"
CDS complement(4047705..4048181)
/codon_start=1
/transl_table=11
/locus_tag="Rv3605c"
/product="Probable conserved secreted protein"
/note="Rv3605c, (MTCY07H7B.17), len: 158 aa. Probable
conserved secreted or membrane protein, identical to
O69527|MLCB2548.04c|ML0227 putative membrane protein from
Mycobacterium leprae (158 aa), FASTA scores: opt: 944,
E(): 2.6e-56, (85.45% identity in 158 aa overlap). Also
similar to other proteins e.g. Q9X8I2|SCE9.09 possible
secreted protein from Streptomyces coelicolor (162 aa),
FASTA scores: opt: 174, E(): 9.2e-05, (31.25% identity in
128 aa overlap); etc. Contains possible N-terminal signal
sequence. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3605c"
/db_xref="EnsemblGenomes-Tr:CCP46428"
/db_xref="GOA:O06277"
/db_xref="InterPro:IPR021517"
/db_xref="UniProtKB/TrEMBL:O06277"
/protein_id="CCP46428.1"
/translation="MGPTRKRDLTAAVVGAAAVGYLLVAVLYRWFPPITVWTGLSLLA
VAVAEALWARYVRVKISDGEIGDGPGWLHPLVVARSLMVAKASAWVGALVTGWWIGVL
AYFLPRRSWLRAAAEDTTGTVVAAGSALALVVAALWLQHCCKSPQDPTEHADGAES"
gene complement(4048181..4048747)
/gene="folK"
/locus_tag="Rv3606c"
CDS complement(4048181..4048747)
/codon_start=1
/transl_table=11
/gene="folK"
/locus_tag="Rv3606c"
/product="2-amino-4-hydroxy-6-
hydroxymethyldihydropteridinepyrophosphokinase FolK
(7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase)
(HPPK) (6-hydroxymethyl-7,8-dihydropterin
pyrophosphokinase) (PPPK)
(2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-
diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin
diphosphokinase)"
/note="Rv3606c, (MTCY07H7B.16), len: 188 aa. Probable
folK,2-amino-4-hydroxy-6-hydroxymethyldihydropterine
pyrophosphokinase, equivalent to
O69528|HPPK_MYCLE|folk|ML0226\MLCB2548.05c
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
pyrophosphokinase from Mycobacterium leprae (191 aa) FASTA
scores: opt: 772, E(): 1.2e-44, (63.15% identity in 190 aa
overlap). Also similar to many e.g.
P71512|HPPK_METEX|folk|FOLA from Methylobacterium
extorquens (158 aa), FASTA scores: opt: 292, E():
1.4e-12,(36.85% identity in 171 aa overlap);
O33726|HPPK_STRPY|folk|SPY1100 from Streptococcus pyogenes
(166 aa), FASTA scores: opt: 234, E(): 1.1e-08, (34.3%
identity in 175 aa overlap); Q9X8I1|SCE9.08 from
Streptomyces coelicolor (203 aa), FASTA scores: opt:
232,E(): 1.7e-08, (43.25% identity in 185 aa overlap);
P26281|HPPK_ECOLI|folk|B0142 from Escherichia coli strain
K12 (158 aa), FASTA scores: opt: 198, E(): 2.6e-06,
(32.85% identity in 143 aa overlap); etc. Belongs to the
HppK family."
/db_xref="EnsemblGenomes-Gn:Rv3606c"
/db_xref="EnsemblGenomes-Tr:CCP46429"
/db_xref="GOA:P9WNC7"
/db_xref="InterPro:IPR000550"
/db_xref="InterPro:IPR035907"
/db_xref="UniProtKB/Swiss-Prot:P9WNC7"
/protein_id="CCP46429.1"
/translation="MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGG
VEQGQFLNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTS
ATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELE
PADRDSVRLFRPSFDLNSRHPVSRAPES"
gene complement(4048744..4049145)
/gene="folB"
/gene_synonym="folX"
/locus_tag="Rv3607c"
CDS complement(4048744..4049145)
/codon_start=1
/transl_table=11
/gene="folB"
/gene_synonym="folX"
/locus_tag="Rv3607c"
/product="Probable dihydroneopterin aldolase FolB (DHNA)"
/note="Rv3607c, (MTCY07H7B.15), len: 133 aa. Probable
folB,dihydroneopterin aldolase, equivalent to
O69529|FOLB_MYCLE|ML0225|MLCB2548.06c probable
dihydroneopterin aldolase from Mycobacterium leprae (132
aa), FASTA scores: opt: 673, E(): 5.1e-37, (74.8% identity
in 131 aa overlap). Also similar to many e.g.
Q9X8I0|FOLB_STRCO|SCE9.07 from Streptomyces coelicolor
(119 aa), FASTA scores: opt: 334, E(): 4.5e-15, (46.15%
identity in 117 aa overlap); P74342|FOLB_SYNY3|SLR1626
from Synechocystis sp. strain PCC 6803 (118 aa) FASTA
scores: opt: 287, E(): 5e-12, (38.45% identity in 117 aa
overlap); P28823|FOLB_BACSU|FOLA from Bacillus subtilis
(120 aa),FASTA scores: opt: 283, E(): 9.2e-12, (39.0%
identity in 118 aa overlap); etc. Belongs to the DHNA
family. Note that previously known as folX."
/db_xref="EnsemblGenomes-Gn:Rv3607c"
/db_xref="EnsemblGenomes-Tr:CCP46430"
/db_xref="GOA:P9WNC5"
/db_xref="InterPro:IPR006156"
/db_xref="InterPro:IPR006157"
/db_xref="PDB:1NBU"
/db_xref="PDB:1Z9W"
/db_xref="UniProtKB/Swiss-Prot:P9WNC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46430.1"
/translation="MADRIELRGLTVHGRHGVYDHERVAGQRFVIDVTVWIDLAEAAN
SDDLADTYDYVRLASRAAEIVAGPPRKLIETVGAEIADHVMDDQRVHAVEVAVHKPQA
PIPQTFDDVAVVIRRSRRGGRGWVVPAGGAV"
gene complement(4049138..4049980)
/gene="folP1"
/locus_tag="Rv3608c"
CDS complement(4049138..4049980)
/codon_start=1
/transl_table=11
/gene="folP1"
/locus_tag="Rv3608c"
/product="Dihydropteroate synthase 1 FolP (DHPS 1)
(dihydropteroate pyrophosphorylase 1) (dihydropteroate
diphosphorylase 1)"
/note="Rv3608c, (MTCY07H7B.14), len: 280 aa. Probable
folP1, dihydropteroate synthase 1, equivalent to
O69530|FOLP (alias Q9S0T0|FOLP and Q9R2U9|FOLP)
dihydroneopterin aldolase from Mycobacterium leprae (284
aa), FASTA scores: opt: 1418, E(): 7.2e-77, (76.75%
identity in 284 aa overlap). Also highly similar to many
e.g. Q9X8H8|SCE9.05 from Streptomyces coelicolor (288
aa),FASTA scores: opt: 953, E(): 2.4e-49, (56.0% identity
in 266 aa overlap); Q9A3I0|CC3224 from Caulobacter
crescentus (274 aa), FASTA scores: opt: 682, E(): 2.6e-33,
(45.5% identity in 268 aa overlap);
P73248|DHPS_SYNY3|FOLP|SLR2026 from Synechocystis sp.
strain PCC 6803 (289 aa), FASTA scores: opt: 665, E():
2.7e-32, (44.55% identity in 265 aa overlap);
P26282|DHPS_ECOLI|FOLP|B3177 from Escherichia coli strain
K12 (282 aa), FASTA scores: opt: 642, E(): 6.1e-31,
(41.95% identity in 274 aa overlap); etc. Contains PS00792
Dihydropteroate synthase signature 1, PS00793
Dihydropteroate synthase signature 2. Similar to other
species DHPS."
/db_xref="EnsemblGenomes-Gn:Rv3608c"
/db_xref="EnsemblGenomes-Tr:CCP46431"
/db_xref="GOA:P9WND1"
/db_xref="InterPro:IPR000489"
/db_xref="InterPro:IPR006390"
/db_xref="InterPro:IPR011005"
/db_xref="PDB:1EYE"
/db_xref="UniProtKB/Swiss-Prot:P9WND1"
/inference="protein motif:PROSITE:PS00793"
/inference="protein motif:PROSITE:PS00792"
/protein_id="CCP46431.1"
/translation="MSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAG
IVDVGGESSRPGATRVDPAVETSRVIPVVKELAAQGITVSIDTMRADVARAALQNGAQ
MVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTPHVPVRYGNVVAEVRADLLAS
VADAVAAGVDPARLVLDPGLGFAKTAQHNWAILHALPELVATGIPVLVGASRKRFLGA
LLAGPDGVMRPTDGRDTATAVISALAALHGAWGVRVHDVRASVDAIKVVEAWMGAERI
ERDG"
gene complement(4049977..4050585)
/gene="folE"
/gene_synonym="gchA"
/locus_tag="Rv3609c"
CDS complement(4049977..4050585)
/codon_start=1
/transl_table=11
/gene="folE"
/gene_synonym="gchA"
/locus_tag="Rv3609c"
/product="GTP cyclohydrolase I FolE (GTP-ch-I)"
/note="Rv3609c, (MTCY07H7B.13), len: 202 aa. Probable folE
(alternate gene name: gchA), GTP cyclohydrolase
I,equivalent to O69531|GCH1_MYCLE|FOLE|ML0223|MLCB2548.08c
GTP cyclohydrolase I from Mycobacterium leprae (205 aa)
FASTA scores: opt: 1112, E(): 3.8e-63, (81.95% identity in
205 aa overlap). Also highly similar to many e.g.
Q9X8I3|GCH1_STRCO|FOLE|SCE9.10c from Streptomyces
coelicolor (201 aa), FASTA scores: opt: 873, E():
4.2e-48,(67.4% identity in 187 aa overlap);
Q9KCC7|MTRA|BH1646 from Bacillus halodurans (188 aa),
FASTA scores: opt: 757, E(): 8.1e-41, (62.3% identity in
183 aa overlap); P19465|GCH1_BACSU|FOLE|MTRA from Bacillus
subtilis (190 aa), FASTA scores: opt: 750, E(): 2.3e-40,
(58.95% identity in 190 aa overlap); etc. Contains PS00860
GTP cyclohydrolase I signature 2. Belongs to the GTP
cyclohydrolase I family."
/db_xref="EnsemblGenomes-Gn:Rv3609c"
/db_xref="EnsemblGenomes-Tr:CCP46432"
/db_xref="GOA:P9WN57"
/db_xref="InterPro:IPR001474"
/db_xref="InterPro:IPR018234"
/db_xref="InterPro:IPR020602"
/db_xref="UniProtKB/Swiss-Prot:P9WN57"
/inference="protein motif:PROSITE:PS00860"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46432.1"
/translation="MSQLDSRSASARIRVFDQQRAEAAVRELLYAIGEDPDRDGLVAT
PSRVARSYREMFAGLYTDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGVAH
VGYIPGDDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALMKKLDPRGVIVVIEAE
HLCMAMRGVRKPGSVTTTSAVRGLFKTNAASRAEALDLILRK"
gene complement(4050601..4052883)
/gene="ftsH"
/locus_tag="Rv3610c"
CDS complement(4050601..4052883)
/codon_start=1
/transl_table=11
/gene="ftsH"
/locus_tag="Rv3610c"
/product="Membrane-bound protease FtsH (cell division
protein)"
/note="Rv3610c, (MT3714, MTCY07H7B.12), len: 760 aa.
FtsH,membrane-bound protease (cell division protein) (see
citations below), equivalent to Q9CD58|FTSH_MYCLE|ML0222
(alias O69532|FTSH) cell division protein FTSH homolog
from Mycobacterium leprae (787 aa), FASTA scores: opt:
4388,E(): 9.6e-205, (87.2% identity in 790 aa overlap).
Also highly similar to many FTSH proteins e.g. O52395|FTSH
from Mycobacterium smegmatis (769 aa), FASTA scores: opt:
3976,E(): 7.6e-185, (82.4% identity in 761 aa overlap);
Q9X8I4|SCE9.11c from Streptomyces coelicolor (668
aa),FASTA scores: opt: 2417, E(): 1.4e-109, (57.2%
identity in 668 aa overlap); P72991|FTH4_SYNY3|SLR1604
from Synechocystis sp. strain PCC 6803 (616 aa), FASTA
scores: opt: 1926, E(): 7.2e-86, (49.35% identity in 612
aa overlap); P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from
Escherichia coli strain K12 (644 aa), FASTA scores: opt:
1859, E(): 1.3e-82, (48.95% identity in 605 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop), and PS00674 AAA-protein family signature.
Belongs to the AAA family of ATPases and peptidase family
M41 (zinc metalloprotease). Cofactor: binds one zinc ion
(potential). Conserved in M. tuberculosis, M. leprae, M.
bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3610c"
/db_xref="EnsemblGenomes-Tr:CCP46433"
/db_xref="GOA:P9WQN3"
/db_xref="InterPro:IPR000642"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR003960"
/db_xref="InterPro:IPR005936"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR037219"
/db_xref="InterPro:IPR041569"
/db_xref="UniProtKB/Swiss-Prot:P9WQN3"
/inference="protein motif:PROSITE:PS00674"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46433.1"
/translation="MNRKNVTRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAITQ
INGDNVKSAQIDDREQQLRLILKKGNNETDGSEKVITKYPTGYAVDLFNALSAKNAKV
STVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKT
TFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIPKGVLLYGPPGTGKTLLARAVAG
EAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKQNSPCIIFVDEIDAVGRQRGAGLG
GGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPD
LAGRRAVLRVHSKGKPMAADADLDGLAKRTVGMTGADLANVINEAALLTARENGTVIT
GPALEEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILAR
GRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEQATKI
ARSMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQPDYSHEVAREIDEEVRKLIEAAH
TEAWEILTEYRDVLDTLAGELLEKETLHRPELESIFADVEKRPRLTMFDDFGGRIPSD
KPPIKTPGELAIERGEPWPQPVPEPAFKAAIAQATQAAEAARSDAGQTGHGANGSPAG
THRSGDRQYGSTQPDYGAPAGWHAPGWPPRSSHRPSYSGEPAPTYPGQPYPTGQADPG
SDESSAEQDDEVSRTKPAHG"
repeat_region complement(4052949..4052966)
/note="18 bp direct repeat 2, GGGTTTGCGATCGCCACG"
gene 4052950..4053603
/locus_tag="Rv3611"
CDS 4052950..4053603
/codon_start=1
/transl_table=11
/locus_tag="Rv3611"
/product="Hypothetical arginine and proline rich protein"
/note="Rv3611, (MTCY07H7B.11c), len: 217 aa. Hypothetical
unknown arg-, pro-rich protein. Possible ORF containing
several direct repeats."
/db_xref="EnsemblGenomes-Gn:Rv3611"
/db_xref="EnsemblGenomes-Tr:CCP46434"
/db_xref="UniProtKB/TrEMBL:O06272"
/protein_id="CCP46434.1"
/translation="MAIANPAEPGAAGRHHQPRGDRKPRAWRQCGPQNGPRRSQAITP
EPGAAGRHHQPRGDRKPRAWRQCGPQNGPRRSQAITPEPGAAGRHHQPRGDRKPRAWR
QCGPQNGPRRSQAITPEPGAAGRHHQPRGDRKPRAWRQCGPQNGPRRSQAITPEPGAA
GRHHQPRGDRKPRAWRQCGPQNGPRRSQAITPEPGAAGRHWLDQRPVVPDGVGKSDS"
repeat_region complement(4052971..4052994)
/note="(24 bp) part of 111 bp direct repeat unit
6,GTGGCGACCCGCTGCACCCGGCTC"
repeat_region complement(4052995..4053105)
/note="111 bp direct repeat unit 5,
GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT
TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG"
repeat_region complement(4053004..4053021)
/note="18 bp direct repeat 1, GGGTTTGCGATCGCCACG"
repeat_region complement(4053106..4053216)
/note="111 bp direct repeat unit 4,
GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT
TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG"
repeat_region complement(4053217..4053327)
/note="111 bp direct repeat unit 3,
GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT
TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG"
repeat_region complement(4053328..4053438)
/note="111 bp direct repeat unit 2,
GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT
TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG"
repeat_region complement(4053439..4053549)
/note="111 bp direct repeat unit 1,
GTGGCGACCCGCTGCACCCGGCTCTGGGGTGATTGCCTGGCTCCTCCTCGGCCCGTTT
TGCGGGCCGCATTGTCGCCAGGCGCGGGGTTTGCGATCGCCACGGGGCTGATG"
gene complement(4053518..4053847)
/locus_tag="Rv3612c"
CDS complement(4053518..4053847)
/codon_start=1
/transl_table=11
/locus_tag="Rv3612c"
/product="Conserved hypothetical protein"
/note="Rv3612c, (MTCY07H7B.10), len: 109 aa. Conserved
hypothetical protein. Residues 58 to 81 highly similar to
N-terminal part of AAK46718|MT2424 hypothetical 3.9 KDA
protein from Mycobacterium tuberculosis strain CDC1551 (36
aa), FASTA scores: opt: 108, E(): 0.38, (69.25% identity
in 26 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3612c"
/db_xref="EnsemblGenomes-Tr:CCP46435"
/db_xref="UniProtKB/TrEMBL:I6YGR2"
/protein_id="CCP46435.1"
/translation="MVAVLTYARQLGFCRSTPPTIPHSRNQLVNKTAGQAAVAESWAD
RVSPGAVTHATGAMCPTLGAHQFEPNQVRCTACLTRTLSCRIFRRRRELPVVGLASGD
PLHPALG"
gene complement(4053881..4054042)
/locus_tag="Rv3613c"
CDS complement(4053881..4054042)
/codon_start=1
/transl_table=11
/locus_tag="Rv3613c"
/product="Hypothetical protein"
/note="Rv3613c, (MTCY07H7B.09), len: 53 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3613c"
/db_xref="EnsemblGenomes-Tr:CCP46436"
/db_xref="UniProtKB/TrEMBL:O06270"
/protein_id="CCP46436.1"
/translation="MCTMPKLWRAFMAGRPLGSTFTPRQPTGAAPNHVRALDDSIDPS
SAPAARAAL"
gene complement(4054142..4054696)
/gene="espD"
/gene_synonym="snm10"
/locus_tag="Rv3614c"
CDS complement(4054142..4054696)
/codon_start=1
/transl_table=11
/gene="espD"
/gene_synonym="snm10"
/locus_tag="Rv3614c"
/product="ESX-1 secretion-associated protein EspD"
/note="Rv3614c, (MTCY07H7B.08), len: 184 aa. EspD, ESX-1
secretion-associated protein, equivalent to
Q49730|ML0407|B1620_C3_264|MLCL383.03 hypothetical 24.2
KDA protein from Mycobacterium leprae (216 aa) FASTA
scores: opt: 899, E(): 1.7e-51, (71.3% identity in 188 aa
overlap); and similar to two hypothetical proteins from
Mycobacterium leprae: Q9CDD6|ML0056 (169 aa), FASTA
scores: opt: 285,E(): 1.2e-11, (38.35% identity in 172 aa
overlap); and O33090|MLCB628.19c (338 aa), FASTA scores:
opt: 289, E(): 1.2e-11, (38.95% identity in 172 aa
overlap). Also highly similar to O69732|Rv3867|MTV027.02
hypothetical 19.9 KDA protein from Mycobacterium
tuberculosis (183 aa), FASTA scores: opt: 563, E(): 1e-29,
(54.9% identity in 173 aa overlap). Rv3614c and Rv3882c
interact, by yeast two-hybrid analysis (See MacGurn et
al., 2005). EspD|Rv3614c is still secreted by M.
tuberculosis H37Rv and Erdman ESX-1 secretion system
mutants, but at levels lower than in wild-type (See Chen
et al., 2012)."
/db_xref="EnsemblGenomes-Gn:Rv3614c"
/db_xref="EnsemblGenomes-Tr:CCP46437"
/db_xref="GOA:P9WJD5"
/db_xref="UniProtKB/Swiss-Prot:P9WJD5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46437.1"
/translation="MDLPGNDFDSNDFDAVDLWGADGAEGWTADPIIGVGSAATPDTG
PDLDNAHGQAETDTEQEIALFTVTNPPRTVSVSTLMDGRIDHVELSARVAWMSESQLA
SEILVIADLARQKAQSAQYAFILDRMSQQVDADEHRVALLRKTVGETWGLPSPEEAAA
AEAEVFATRYSDDCPAPDDESDPW"
gene complement(4054812..4055123)
/gene="espC"
/gene_synonym="snm9"
/locus_tag="Rv3615c"
CDS complement(4054812..4055123)
/codon_start=1
/transl_table=11
/gene="espC"
/gene_synonym="snm9"
/locus_tag="Rv3615c"
/product="ESX-1 secretion-associated protein EspC"
/note="Rv3615c, (MTCY07H7B.07), len: 103 aa. EspC, ESX-1
secretion-associated protein, equivalent to
Q49723|ML0406|B1620_C2_214|MLCL383 hypothetical 11.1 KDA
protein from Mycobacterium leprae (106 aa), FASTA scores:
opt: 364, E(): 4.1e-18, (60.85% identity in 92 aa
overlap). Also shows similarity to
P96212|Rv3865|MTCY01A6.03 hypothetical 10.6 KDA protein
from Mycobacterium tuberculosis (103 aa), FASTA scores:
opt: 198, E(): 6.8e-07, (36.25% identity in 102 aa
overlap). Has been shown to interact with itself, by yeast
two-hybrid analysis (See MacGurn et al., 2005)."
/db_xref="EnsemblGenomes-Gn:Rv3615c"
/db_xref="EnsemblGenomes-Tr:CCP46438"
/db_xref="GOA:P9WJD7"
/db_xref="InterPro:IPR022536"
/db_xref="UniProtKB/Swiss-Prot:P9WJD7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46438.1"
/translation="MTENLTVQPERLGVLASHHDNAAVDASSGVEAAAGLGESVAITH
GPYCSQFNDTLNVYLTAHNALGSSLHTAGVDLAKSLRIAAKIYSEADEAWRKAIDGLF
T"
gene complement(4055197..4056375)
/gene="espA"
/locus_tag="Rv3616c"
CDS complement(4055197..4056375)
/codon_start=1
/transl_table=11
/gene="espA"
/locus_tag="Rv3616c"
/product="ESX-1 secretion-associated protein A, EspA"
/note="Rv3616c, (MTCY07H7B.06), len: 392 aa. EspA, ESX-1
secretion-associated protein A. Ala-, gly-rich
protein,equivalent to
Q49722|ML0405|B1620_C2_213|MLCL383.01 hypothetical 40.8
KDA protein from Mycobacterium leprae (394 aa) FASTA
scores: opt: 1620, E(): 5.3e-75, (62.7% identity in 394 aa
overlap). Also similar to P96213|Rv3864|MTCY01A6.04c
hypothetical 42.1 KDA protein from Mycobacterium
tuberculosis (402 aa), FASTA scores: opt: 389, E():
1.1e-12, (31.75% identity in 400 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3616c"
/db_xref="EnsemblGenomes-Tr:CCP46439"
/db_xref="GOA:P9WJE1"
/db_xref="UniProtKB/Swiss-Prot:P9WJE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46439.1"
/translation="MSRAFIIDPTISAIDGLYDLLGIGIPNQGGILYSSLEYFEKALE
ELAAAFPGDGWLGSAADKYAGKNRNHVNFFQELADLDRQLISLIHDQANAVQTTRDIL
EGAKKGLEFVRPVAVDLTYIPVVGHALSAAFQAPFCAGAMAVVGGALAYLVVKTLINA
TQLLKLLAKLAELVAAAIADIISDVADIIKGTLGEVWEFITNALNGLKELWDKLTGWV
TGLFSRGWSNLESFFAGVPGLTGATSGLSQVTGLFGAAGLSASSGLAHADSLASSASL
PALAGIGGGSGFGGLPSLAQVHAASTRQALRPRADGPVGAAAEQVGGQSQLVSAQGSQ
GMGGPVGMGGMHPSSGASKGTTTKKYSEGAAAGTEDAERAPVEADAGGGQKVLVRNVV
"
gene 4057733..4058701
/gene="ephA"
/locus_tag="Rv3617"
CDS 4057733..4058701
/codon_start=1
/transl_table=11
/gene="ephA"
/locus_tag="Rv3617"
/product="Probable epoxide hydrolase EphA (epoxide
hydratase) (arene-oxide hydratase)"
/note="Rv3617, (MTCY07H7B.05c, MTCY15C10.35c), len: 322
aa. Probable ephA, epoxide hydrolase (see citation
below),similar to many e.g. Q9A8W9|CC1229 from Caulobacter
crescentus (330 aa), FASTA scores: opt: 965, E():
1.8e-51,(46.15% identity in 323 aa overlap);
Q9M9W5|F18C1.13 from Arabidopsis thaliana (Mouse-ear
cress) (331 aa), FASTA scores: opt: 778, E(): 4.3e-40,
(40.35% identity in 332 aa overlap); Q9S7P1 from Oryza
sativa (Rice) (322 aa), FASTA scores: opt: 774, E():
7.4e-40, (41.1% identity in 321 aa overlap);
P80299|HYES_RAT|EPHX2 from Rattus norvegicus (Rat) (554
aa), FASTA scores: opt: 759, E(): 9.5e-39,(40.5% identity
in 306 aa overlap) (similarity only with the C-terminal
part for this one); etc. Similar to alpha/beta hydrolase
fold. Contains PS00888 Cyclic nucleotide-binding domain
signature 1."
/db_xref="EnsemblGenomes-Gn:Rv3617"
/db_xref="EnsemblGenomes-Tr:CCP46440"
/db_xref="GOA:I6YGS0"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:I6YGS0"
/inference="protein motif:PROSITE:PS00888"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46440.1"
/translation="MGAPTERLVDTNGVRLRVVEAGEPGAPVVILAHGFPELAYSWRH
QIPALADAGYHVLAPDQRGYGGSSRPEAIEAYDIHRLTADLVGLLDDVGAERAVWVGH
DWGAVVVWNAPLLHADRVAAVAALSVPALPRAQVPPTQAFRSRFGENFFYILYFQEPG
IADAELNGDPARTMRRMIGGLRPPGDQSAAMRMLAPGPDGFIDRLPEPAGLPAWISQE
ELDHYIGEFTRTGFTGGLNWYRNFDRNWETTADLAGKTISVPSLFIAGTADPVLTFTR
TDRAAEVISGPYREVLIDGAGHWLQQERPGEVTAALLEFLTGLELR"
gene 4058698..4059885
/locus_tag="Rv3618"
CDS 4058698..4059885
/codon_start=1
/transl_table=11
/locus_tag="Rv3618"
/product="Possible monooxygenase"
/note="Rv3618, (MTCY15C10.34c, MTCY07H7B.04c), len: 395
aa. Possible monooxygenase, similar to others (principally
bacterial luciferases alpha chain) e.g. Q9JN87|MMYO
putative alkanal monooxygenase from Streptomyces
coelicolor (373 aa), FASTA scores: opt: 949, E(): 8.9e-54,
(41.7% identity in 374 aa overlap); Q9EUT9|limb limonene
monooxygenase from Rhodococcus erythropolis (387 aa),
FASTA scores: opt: 856, E(): 9.1e-48, (42.0% identity in
388 aa overlap); AAK72698 LUXA-like protein from
Bradyrhizobium japonicum (458 aa) FASTA scores: opt: 350,
E(): 4.4e-15,(29.7% identity in 347 aa overlap);
Q9K4C1|2SC6G5.34c putative alkanal monooxygenase
(luciferase) from Streptomyces coelicolor (342 aa), FASTA
scores: opt: 291,E(): 2.2e-11, (26.5% identity in 362 aa
overlap); etc. Also similar to P95278|Rv1936|MTCY09F9.28c
hypothetical 41.8 KDA protein from Mycobacterium
tuberculosis (369 aa), FASTA scores: opt: 473, E():
4.3e-23, (32.55% identity in 378 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3618"
/db_xref="EnsemblGenomes-Tr:CCP46441"
/db_xref="GOA:I6X7W8"
/db_xref="InterPro:IPR011251"
/db_xref="InterPro:IPR036661"
/db_xref="UniProtKB/TrEMBL:I6X7W8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46441.1"
/translation="MKAPLRFGVFITPFHPTGQSPTVALQYDMERVVALDRLGYDEAW
FGEHHSGGYELIACPEVFIAAAAERTTHIRLGTGVVSLPYHHPLMVADRWVLLDHLTR
GRVMFGTGPGALPSDAYMMGIDPVEQRRMMQESLEAILALFRAAPDERIDRHSDWFTL
REAQLHIRPYTWPYPEIATAAMISPSGPRLAGALGTSLLSLSMSVPGGYAALETAWGV
VREQAAKAGRGEPDRADWRVLSIMHLSDSRDQAIDDCTYGLPDFSRYFGAAGFVPLAN
TVEGTQSSREFVEQYAAKGNCCIGTPDDAIAHIEDLLHRSGGFGTLLLLGHDWAPPPA
TFHSYELFARAVIPYFKGQLAAPRASHEWARGKRDQLIGRAGEAVVKAITEHVAEQGE
AGS"
gene complement(4059984..4060268)
/gene="esxV"
/gene_synonym="ES6_1"
/gene_synonym="Mtb9.9D"
/locus_tag="Rv3619c"
CDS complement(4059984..4060268)
/codon_start=1
/transl_table=11
/gene="esxV"
/gene_synonym="ES6_1"
/gene_synonym="Mtb9.9D"
/locus_tag="Rv3619c"
/product="Putative ESAT-6 like protein EsxV (ESAT-6 like
protein 1)"
/note="Rv3619c, (MTCY15C10.33, MTCY07H7B.03, MT3721), len:
94 aa. EsxV, ESAT-6 like protein (see citations
below),highly similar to many Mycobacterial ESAT-6 like
proteins e.g. O53942|ES65_MYCTU putative ESAT-6 like
protein 5 from Mycobacterium tuberculosis (94 aa), FASTA
scores: opt: 582,E(): 4.4e-33, (92.55% identity in 94 aa
overlap); Q49946|ES6X_MYCLE|U1756D putative ESAT-6 like
protein X from Mycobacterium leprae (95 aa), FASTA scores:
opt: 409,E(): 2.5e-21, (64.15% identity in 92 aa overlap);
etc. Strictly identical to
P96364|ES61_MYCTU|Rv1037c|MT1066|MTCY10G2.12 putative
ESAT-6 like protein 1 (94 aa). Belongs to the ESAT6
family. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3619c"
/db_xref="EnsemblGenomes-Tr:CCP46442"
/db_xref="GOA:P0DOA7"
/db_xref="InterPro:IPR009416"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P0DOA7"
/protein_id="CCP46442.1"
/translation="MTINYQFGDVDAHGAMIRAQAGSLEAEHQAIISDVLTASDFWGG
AGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA"
gene complement(4060295..4060591)
/gene="esxW"
/gene_synonym="ES6_10"
/gene_synonym="QILSS"
/locus_tag="Rv3620c"
CDS complement(4060295..4060591)
/codon_start=1
/transl_table=11
/gene="esxW"
/gene_synonym="ES6_10"
/gene_synonym="QILSS"
/locus_tag="Rv3620c"
/product="Putative ESAT-6 like protein EsxW (ESAT-6 like
protein 10)"
/note="Rv3620c, (MTCY15C10.32, MTCY07H7B.02, MT3722), len:
98 aa. EsxW, ESAT-6 like protein (see citation below).
Member of the M. tuberculosis hypothetical QILSS protein
family with Rv1038c, Rv1792, Rv2347c and
Rv1197|O05299|ES63_MYCTU|MT1235|MTCI364.09 putative ESAT-6
like protein 3 from Mycobacterium tuberculosis (98
aa),FASTA scores: opt: 638, E(): 2.3e-36, (97.95% identity
in 98 aa overlap). Also similar to Q49945|ES6Y_MYCLE
putative ESAT-6 like protein Y from Mycobacterium leprae
(100 aa),FASTA scores: opt: 370, E(): 2.1e-18, (57.9%
identity in 95 aa overlap); etc. Belongs to the ESAT6
family."
/db_xref="EnsemblGenomes-Gn:Rv3620c"
/db_xref="EnsemblGenomes-Tr:CCP46443"
/db_xref="GOA:P9WNI3"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNI3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46443.1"
/translation="MTSRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAG
WSGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS"
gene complement(4060648..4061889)
/gene="PPE65"
/locus_tag="Rv3621c"
CDS complement(4060648..4061889)
/codon_start=1
/transl_table=11
/gene="PPE65"
/locus_tag="Rv3621c"
/product="PPE family protein PPE65"
/note="Rv3621c, (MTCY15C10.31, MTCY07H7B.01), len: 413 aa.
PPE65, Member of the Mycobacterium tuberculosis PPE
family,ala-, gly-rich proteins, similar to many e.g.
Q10813|YS92_MYCTU|Rv2892c|MT2959|MTCY274.23c (408 aa)
FASTA scores: opt: 955, E(): 1.8e-42, (44.45% identity in
423 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3621c"
/db_xref="EnsemblGenomes-Tr:CCP46444"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR022171"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHX3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46444.1"
/translation="MLDFAQLPPEVNSALMYAGPGSGPMLAAAAAWEALAAELQTTAS
TYDALITGLADGPWQGSSAASMVAAATPQVAWLRSTAGQAEQAGSQAVAAASAYEAAF
FATVPPPEIAANRALLMALLATNFLGQNTAAIAATEAQYAEMWAQDAAAMYGYAGASA
AATQLSPFNPAAQTINPAGLASQAASVGQAVSGAANAQALTDIPKALFGLSGIFTNEP
PWLTDLGKALGLTGHTWSSDGSGLIVGGVLGDFVQGVTGSAELDASVAMDTFGKWVSP
ARLMVTQFKDYFGLAHDLPKWASEGAKAAGEAAKALPAAVPAIPSAGLSGVAGAVGQA
ASVGGLKVPAVWTATTPAASPAVLAASNGLGAAAAAEGSTHAFGGMPLMGSGAGRAFN
NFAAPRYGFKPTVIAQPPAGG"
gene complement(4061899..4062198)
/gene="PE32"
/locus_tag="Rv3622c"
CDS complement(4061899..4062198)
/codon_start=1
/transl_table=11
/gene="PE32"
/locus_tag="Rv3622c"
/product="PE family protein PE32"
/note="Rv3622c, (MTCY15C10.30), len: 99 aa. PE32, Member
of the Mycobacterium tuberculosis PE family (see Brennan
and Delogu, 2002), but no glycine rich C-terminus present.
Similar to others e.g. O53938|Rv1788|MTV049.10 (99
aa),FASTA scores: opt: 376, E(): 7.1e-17, (65.6% identity
in 96 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3622c"
/db_xref="EnsemblGenomes-Tr:CCP46445"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:I6YGS7"
/protein_id="CCP46445.1"
/translation="MSIMHAEPEMLAATAGELQSINAVARAGNAAVAGPTTGVVPAAA
DLVSLLTASQFAAHAQLYQAISAEAMAVQEQLATTLGISAGSYAATEAANAATIA"
gene 4062527..4063249
/gene="lpqG"
/locus_tag="Rv3623"
CDS 4062527..4063249
/codon_start=1
/transl_table=11
/gene="lpqG"
/locus_tag="Rv3623"
/product="Probable conserved lipoprotein LpqG"
/note="Rv3623, (MTCY15C10.29c), len: 240 aa. Probable
lpqG,conserved lipoprotein, showing some similarity with
hypothetical proteins e.g. Q57432 from Methanosarcina
barkeri (251 aa), FASTA scores: opt: 319, E():
6.8e-12,(31.2% identity in 218 aa overlap); Q9PEA5|XF1123
outer membrane protein from Xylella fastidiosa (242 aa)
FASTA scores: opt: 312, E(): 1.7e-11, (28.25% identity in
237 aa overlap); BAB49547|MLR2408 hypothetical protein
from Rhizobium loti (Mesorhizobium loti) (236 aa), FASTA
scores: opt: 304, E(): 5e-11, (27.05% identity in 244 aa
overlap); etc. Has suitable signal peptide and prokaryotic
membrane lipoprotein lipid attachment site (PS00013)."
/db_xref="EnsemblGenomes-Gn:Rv3623"
/db_xref="EnsemblGenomes-Tr:CCP46446"
/db_xref="InterPro:IPR007497"
/db_xref="UniProtKB/TrEMBL:I6X7X3"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46446.1"
/translation="MIRLVRHSIALVAAGLAAALSGCDSHNSGSLGADPRQVTVFGSG
QVQGVPDTLIADVGIQVTAADVTSAMNQTNDRQQAVIDALVGAGLDRKDIRTTRVTVA
PQYSNPEPAGTATITGYRADNDIEVKIHPTDAASRLLALVVSTGGDATRISSVSYSIG
DDSQLVKDARARAFQDAKNRADQYAQLSGLRLGKVISISEASGAAPTHEAPAPPRGLS
AVPLEPGQQTVGFSVTVVWELT"
gene complement(4063254..4063904)
/gene="hpt"
/gene_synonym="hprT"
/locus_tag="Rv3624c"
CDS complement(4063254..4063904)
/codon_start=1
/transl_table=11
/gene="hpt"
/gene_synonym="hprT"
/locus_tag="Rv3624c"
/product="Hypoxanthine-guanine phosphoribosyltransferase
Hpt (HGPRT) (HGPRTase) (hypoxanthine
phosphoribosyltransferase) (imp pyrophosphorylase) (imp
diphosphorylase) (transphosphoribosyltransferase) (guanine
phosphoribosyltransferase)"
/note="Rv3624c, (MTCY15C10.28), len: 216 aa. Hpt
(alternate gene name: hprT), hypoxanthine-guanine
phosphoribosyltransferase (but seems to have a 35 aa
extension at N-terminus), equivalent to other
mycobacterial hypoxanthine-guanine
phosphoribosyltransferases e.g. P96794 from Mycobacterium
avium (203 aa), FASTA scores: opt: 1136,E(): 1.2e-65,
(88.5% identity in 200 aa overlap); and O69537|HPT|ML0214
from Mycobacterium leprae (213 aa), FASTA scores: opt:
1115, E(): 2.8e-64, (81.6% identity in 212 aa overlap).
Also similar to others e.g. Q9X8I5|SCE9.12c from
Streptomyces coelicolor (187 aa), FASTA scores: opt:
724,E(): 2.4e-39, (60.55% identity in 180 aa overlap);
P37472|HPRT_BACSU|HPT from Bacillus subtilis (180 aa)
FASTA scores: opt: 574, E(): 9.1e-30, (48.6% identity in
181 aa overlap); etc. Equivalent to AAK48087 from
Mycobacterium tuberculosis strain CDC1551 (202 aa) but
longer 14 aa. Contains PS00103 Purine/pyrimidine
phosphoribosyltransferases signature. Belongs to the
purine/pyrimidine phosphoribosyltransferase family."
/db_xref="EnsemblGenomes-Gn:Rv3624c"
/db_xref="EnsemblGenomes-Tr:CCP46447"
/db_xref="GOA:P9WHQ9"
/db_xref="InterPro:IPR000836"
/db_xref="InterPro:IPR005904"
/db_xref="InterPro:IPR029057"
/db_xref="PDB:4RHT"
/db_xref="PDB:4RHU"
/db_xref="PDB:4RHX"
/db_xref="PDB:4RHY"
/db_xref="PDB:5KNP"
/db_xref="PDB:5KNQ"
/db_xref="PDB:5KNY"
/db_xref="UniProtKB/Swiss-Prot:P9WHQ9"
/inference="protein motif:PROSITE:PS00103"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46447.1"
/translation="MTPALVVGPAAWHAVHVTQSSSAITPGQTAELYPGDIKSVLLTA
EQIQARIAELGEQIGNDYRELSATTGQDLLLITVLKGAVLFVTDLARAIPVPTQFEFM
AVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSL
RVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ"
gene complement(4063901..4064872)
/gene="mesJ"
/locus_tag="Rv3625c"
CDS complement(4063901..4064872)
/codon_start=1
/transl_table=11
/gene="mesJ"
/locus_tag="Rv3625c"
/product="Possible cell cycle protein MesJ"
/note="Rv3625c, (MT3727, MTCY15C10.27), len: 323 aa.
Possible mesJ, cell cycle protein, equivalent to
O69538|Y0C5_MYCLE|ML0213|MLCB2548.18c hypothetical 34.1
KDA protein from Mycobacterium leprae (323 aa) FASTA
scores: opt: 1592, E(): 9e-92, (78.0% identity in 327 aa
overlap). Similar to bacterial hypothetical proteins
Q9X8I6|SCE9.13c from Streptomyces coelicolor (352 aa)
FASTA scores: opt: 705, E(): 1.4e-36, (47.85% identity in
305 aa overlap); and Q9HXZ3|PA3638 from Pseudomonas
aeruginosa (442 aa), FASTA scores: opt: 382, E(): 2e-16,
(40.6% identity in 271 aa overlap). But also similar (or
with similarity) to bacterial cell cycle proteins (MESJ)
e.g. Q9KPX0|VC2242 MESJ protein from Vibrio cholerae (440
aa), FASTA scores: opt: 363, E(): 3e-15, (34.8% identity
in 253 aa overlap); Q9RV23|DR1207 (600 aa) cell cycle
protein MESJ (putative/cytosine deaminase-related protein)
from Deinococcus radiodurans (600 aa), FASTA scores: opt:
310,E(): 7.6e-12, (36.6% identity in 265 aa overlap)
(similar only at the N-terminal end); Q9PFJ8|XF0659 cell
cycle protein from Xylella fastidiosa (437 aa), FASTA
scores: opt: 301, E(): 2.1e-11, (35.05% identity in 271 aa
overlap); P52097|MESJ_ECOLI|B0188 putative cell cycle
protein MESJ from Escherichia coli strain K12(432 aa)
FASTA scores: opt: 299, E(): 2.8e-11, (34.65% identity in
277 aa overlap); etc. Belongs to the UPF0072 (MESJ/YCF62)
family."
/db_xref="EnsemblGenomes-Gn:Rv3625c"
/db_xref="EnsemblGenomes-Tr:CCP46448"
/db_xref="GOA:P9WG53"
/db_xref="InterPro:IPR011063"
/db_xref="InterPro:IPR012094"
/db_xref="InterPro:IPR012795"
/db_xref="InterPro:IPR014729"
/db_xref="InterPro:IPR015262"
/db_xref="UniProtKB/Swiss-Prot:P9WG53"
/protein_id="CCP46448.1"
/translation="MDRQSAVAQLRAAAEQFARVHLDACDRWSVGLSGGPDSLALTAV
AARLWPTTALIVDHGLQPGSATVAETARIQAISLGCVDARVLCVQVGAAGGREAAARS
ARYSALEEHRDGPVLLAHTLDDQAETVLLGLGRGSGARSIAGMRPYDPPWCRPLLGVR
RSVTHAACRELGLTAWQDPHNTDRRFTRTRLRTEVLPLLEDVLGGGVAEALARTATAL
REDTDLIDTIAAQALPGAAVAGSRGQELSTSALTALPDAVRRRVIRGWLLAGGATGLT
DRQIRGVDRLVTAWRGQGGVAVGSTLRGQRLVAGRRDGVLVLRREPV"
gene complement(4064851..4065903)
/locus_tag="Rv3626c"
CDS complement(4064851..4065903)
/codon_start=1
/transl_table=11
/locus_tag="Rv3626c"
/product="Conserved hypothetical protein"
/note="Rv3626c, (MTCY15C10.26), len: 350 aa. Conserved
hypothetical protein, similar to Q9X8I7|SCE9.14c
hypothetical protein from Streptomyces coelicolor (375 aa)
FASTA scores: opt: 720, E(): 2.2e-38, (41.55% identity in
361 aa overlap); and shows some similarity to
Q9HPS0|VNG1497C hypothetical protein (317 aa) FASTA
scores: opt: 226, E(): 4.5e-07, (29.7% identity in 347 aa
overlap). Contains neutral zinc metallopeptidases,
zinc-binding region signature (PS00142)."
/db_xref="EnsemblGenomes-Gn:Rv3626c"
/db_xref="EnsemblGenomes-Tr:CCP46449"
/db_xref="GOA:O06381"
/db_xref="InterPro:IPR018766"
/db_xref="InterPro:IPR022454"
/db_xref="InterPro:IPR042271"
/db_xref="UniProtKB/TrEMBL:O06381"
/inference="protein motif:PROSITE:PS00142"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46449.1"
/translation="MTGASELTLGNTVDWEFAASVGERLARPAPPSTEYTRRQVIDEL
TVAAEKAEPPVRDVTGLIADGVVPPARVVDRPAWIRSAAESMRAMTHGSAKPRGFLTG
RITGAQTGAVLAFVASGILGQYDPFGAAGEGCLLLVYPNVIAVERQLRVEPSDFRLWV
CLHEVTHRVQFTANPWLSGYMSQALNLLTFEPVDDIGRVVSRLADFIRSRGHGTDDSE
VNPSGILGLVRAVQSEPQRKALDQLLVLGTLLEGHAEHVMDAVGPMVVPSVATIRRRF
DDRRHHKQPPLQRLVRALLGFDAKLSQYTRGKAFVDHVVDRAGMKLFNTIWSGPETLP
LPAEIENPQRWIDRVL"
gene complement(4065900..4067285)
/locus_tag="Rv3627c"
CDS complement(4065900..4067285)
/codon_start=1
/transl_table=11
/locus_tag="Rv3627c"
/product="Conserved protein"
/note="Rv3627c, (MTCY15C10.25), len: 461 aa. Conserved
ala-rich protein which may have cleavable signal peptide
at N-terminal end. Equivalent to
O69539|MLCB2548.20c|ML0211 hypothetical 47.2 KDA protein
from Mycobacterium leprae (461 aa), FASTA scores: opt:
2295, E(): 3.5e-116, (76.2% identity in 462 aa overlap);
and C-terminal end shows similarity with O05758|MLCB5.28c
hypothetical 24.1 KDA protein from Mycobacterium leprae
(225 aa), FASTA scores: opt: 268, E(): 1.8e-07, (32.25%
identity in 220 aa overlap). Also similar (or with
similarity) to various proteins (notably penicillin
binding proteins) e.g. Q9X8I8|SCE9.15c hypothetical 45.9
KDA protein from Streptomyces coelicolor (459 aa) FASTA
scores: opt: 707,E(): 8.3e-31, (35.75% identity in 439 aa
overlap); Q9Z541|SC9B2.18c putative carboxypeptidase from
Streptomyces coelicolor (451 aa), FASTA scores: opt:
450,E(): 5.3e-17, (31.75% identity in 469 aa overlap);
Q9JVV4|NMA0665 putative peptidase from Neisseria
meningitidis (serogroup A) (or Q9JY10|NMB1797 from
serogroup B) (469 aa), FASTA scores: opt: 269, E():
3e-07,(26.15% identity in 463 aa overlap); O85665|PBP3
penicillin binding protein 3 from Neisseria gonorrhoeae
(469 aa),FASTA scores: opt: 265, E(): 4.9e-07, (31.85%
identity in 201 aa overlap); P45161|PBP4_HAEIN|DACB|HI1330
penicillin-binding protein 4 precursor/peptidase (479 aa)
FASTA scores: opt: 230, E(): 3.8e-05, (27.9% identity in
394 aa overlap); P24228|PBP4_ECOLI|DACB|B3182
penicillin-binding protein 4 precursor from Escherichia
coli strain K12 (477 aa), FASTA scores: opt: 166, E():
0.1,(28.2% identity in 408 aa overlap); etc. Predicted to
be an outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3627c"
/db_xref="EnsemblGenomes-Tr:CCP46450"
/db_xref="GOA:O06380"
/db_xref="InterPro:IPR000667"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/Swiss-Prot:O06380"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46450.1"
/translation="MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAP
APPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELW
QRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLS
AAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGD
IAPIEAAMIDAGRIQPTTVNSRRSRTPALDAGRELAKALGLDPAAVTIASAPAGARQL
AVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGAVDAVTSRLNTAHID
TAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERF
LDAATDQGPAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDAL
ATKLWFCGCTT"
gene 4067423..4067911
/gene="ppa"
/locus_tag="Rv3628"
CDS 4067423..4067911
/codon_start=1
/transl_table=11
/gene="ppa"
/locus_tag="Rv3628"
/product="Inorganic pyrophosphatase Ppa (pyrophosphate
phospho-hydrolase) (PPASE) (inorganic diphosphatase)
(diphosphate phospho-hydrolase)"
/note="Rv3628, (MTCY15C10.24), len: 162 aa. Ppa, inorganic
pyrophosphatase (see Triccas & Gicquel 2001), identical to
O69540|IPYR_MYCLEPPA|ML0210|MLCB2548.21 inorganic
pyrophosphatase from Mycobacterium leprae (162 aa) FASTA
scores: opt: 1018, E(): 1.3e-59, (89.5% identity in 162 aa
overlap). Also highly similar to many bacterial
pyrophosphatases e.g. Q9X8I9|IPYR_STRCO|PPA|SCE9.16 from
Streptomyces coelicolor (163 aa), FASTA scores: opt:
773,E(): 1.3e-43, (67.5% identity in 163 aa overlap);
O05545|IPYR_GLUOX|PPA from Gluconobacter oxydans
(Gluconobacter suboxydans) (176 aa), FASTA scores: opt:
553, E(): 3.2e-29, (53.8% identity in 145 aa overlap);
P77992|IPYR_THELI|PPA from Thermococcus litoralis (176 aa)
FASTA scores: opt: 537, E(): 3.5e-28, (49.35% identity in
152 aa overlap); P50308|IPYR_SULAC|PPA from Sulfolobus
acidocaldarius (173 aa), FASTA scores: opt: 518, E():
6e-27, (45.3% identity in 159 aa overlap); etc. Belongs to
the PPASE family. Cofactor: requires the presence of
divalent metal cation. Magnesium confers the highest
activity. Binds 4 divalent cations per subunit (by
similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3628"
/db_xref="EnsemblGenomes-Tr:CCP46451"
/db_xref="GOA:P9WI55"
/db_xref="InterPro:IPR008162"
/db_xref="InterPro:IPR036649"
/db_xref="PDB:1SXV"
/db_xref="PDB:1WCF"
/db_xref="PDB:2UXS"
/db_xref="PDB:4Z70"
/db_xref="PDB:4Z71"
/db_xref="PDB:4Z72"
/db_xref="PDB:4Z73"
/db_xref="PDB:4Z74"
/db_xref="PDB:5KDE"
/db_xref="PDB:5KDF"
/db_xref="UniProtKB/Swiss-Prot:P9WI55"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46451.1"
/translation="MQFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMAYPTDYGF
IEDTLGDDGDPLDALVLLPQPVFPGVLVAARPVGMFRMVDEHGGDDKVLCVPAGDPRW
DHVQDIGDVPAFELDAIKHFFVHYKDLEPGKFVKAADWVDRAEAEAEVQRSVERFKAG
TH"
gene complement(4067957..4069054)
/locus_tag="Rv3629c"
CDS complement(4067957..4069054)
/codon_start=1
/transl_table=11
/locus_tag="Rv3629c"
/product="Probable conserved integral membrane protein"
/note="Rv3629c, (MTCY15C10.23), len: 365 aa. Probable
conserved integral membrane protein, equivalent to
O69543|MLCB2548.26|ML0205 putative membrane protein from
Mycobacterium leprae (356 aa), FASTA scores: opt:
1547,E(): 3e-89, (66.2% identity in 361 aa overlap). Also
similar to other membrane and hypothetical proteins e.g.
CAC37534|SCIF3.15c putative integral membrane protein from
Streptomyces coelicolor (363 aa), FASTA scores: opt:
819,E(): 7.7e-44, (51.55% identity in 351 aa overlap);
Q9CGK3|YKJK hypothetical protein from Lactococcus lactis
(subsp. lactis) (Streptococcus lactis) (339 aa) FASTA
scores: opt: 683, E(): 2.2e-35, (48.3% identity in 350 aa
overlap); Q9KY24|SCC8A.24c putative integral membrane
protein from Streptomyces coelicolor (380 aa) FASTA
scores: opt: 528, E(): 1.1e-25, (50.25% identity in 372 aa
overlap); Q9RJH8|SCF73.09 putative integral membrane
protein from Streptomyces coelicolor (370 aa) FASTA
scores: opt: 439, E(): 3.9e-20, (50.2% identity in 384 aa
overlap); Q9PE36|XF1192 integral membrane protein from
Xylella fastidiosa (341 aa), FASTA scores: opt: 337, E():
8.3e-14,(47.65% identity in 361 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3629c"
/db_xref="EnsemblGenomes-Tr:CCP46452"
/db_xref="InterPro:IPR007427"
/db_xref="UniProtKB/TrEMBL:O06378"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46452.1"
/translation="MSTFRIFGFSLLMTVVALVTGYLHGGPTALFLLAVLALLEVSLS
FDNAIINAAILQRMSPFWQRMFLTIGILIAVFGMRLVFPLAIIWTTAGLDPVRAMELA
LRPPAHGALEFADGSPSYEKLITAAHPQIAAFGGMFLLMLFLDFVVHDRDIKWLKWIE
VPFARIGRLGQVPVIVASVGLVLAGALLTHSSDQRGTVLIAGLLGMVTYLVVNGISRA
FRPAGLGEATPGVQARQAAGKAGCALFLYLEVLDAAFSFDGVTGAFAITTDPIIIALG
LGVVGAMFVRSITIYLVRQDTLDRYVYLEHGAHWAIGALAIILLLSIDHRFAVPEWVT
ASVGVVFIGAAFTESVRRNRLTVRSPTKFGS"
gene 4069175..4070470
/locus_tag="Rv3630"
CDS 4069175..4070470
/codon_start=1
/transl_table=11
/locus_tag="Rv3630"
/product="Probable conserved integral membrane protein"
/note="Rv3630, (MTCY15C10.22c), len: 431 aa. Probable
conserved integral membrane, highly similar to
P71789|YF10_MYCTU|Rv1510|MTCY277.32 hypothetical 44.3 KDA
protein from Mycobacterium tuberculosis (432 aa) FASTA
scores: opt: 1940, E(): 2.3e-103, (70.75% identity in 424
aa overlap). Note that N-terminal end is highly similar to
AAK45825|MT1558 hypothetical 18.1 KDA protein from
Mycobacterium tuberculosis strain CDC1551 (172 aa) FASTA
scores: opt: 649, E(): 4.2e-30, (61.65% identity in 167 aa
overlap); and C-terminal end is highly similar to
AAK45826|MT1560 hypothetical 25.8 KDA protein from
Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA
scores: opt: 1269, E(): 2.6e-65, (76.7% identity in 253 aa
overlap). Contains PS00639 Eukaryotic thiol (cysteine)
proteases histidine active site, so could be a protease."
/db_xref="EnsemblGenomes-Gn:Rv3630"
/db_xref="EnsemblGenomes-Tr:CCP46453"
/db_xref="GOA:P9WKX9"
/db_xref="UniProtKB/Swiss-Prot:P9WKX9"
/inference="protein motif:PROSITE:PS00639"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46453.1"
/translation="MAVGAAAVTEVGDTASPVGSSGASGGAIASGSVARVGTAAAVTA
LCGYAVIYLAARNLAPNGFSVFGVFWGAFGLVTGAANGLLQETTREVRSLGYLDVSAD
GRRTHPLRVSGMVGLGSLVVIAGSSPLWSGRVFAEARWLSVALLSIGLAGFCLHATLL
GMLAGTNRWTQYGALMVADAVIRVVVAAATFVIGWQLVGFIWATVAGSVAWLIMLMTS
PPTRAAARLMTPGATATFLRGAAHSIIAAGASAILVMGFPVLLKLTSNELGAQGGVVI
LAVTLTRAPLLVPLTAMQGNLIAHFVDERTERIRALIAPAALIGGVGAVGMLAAGVVG
PWIMRVAFGSEYQSSSALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYSLGWVGATVG
SGLLLLLPLSLETRTVVALLCGPLVGIGVHLVALARTDE"
gene 4070514..4071239
/locus_tag="Rv3631"
CDS 4070514..4071239
/codon_start=1
/transl_table=11
/locus_tag="Rv3631"
/product="Possible transferase (possibly
glycosyltransferase)"
/note="Rv3631, (MTCY15C10.21c), len: 241 aa. Possible
transferase, more specifically a glycosyltransferase
,equivalent to O69542|MLCB2548.24c|ML0207 putative
transferase (putative glycosyltransferase) from
Mycobacterium leprae (239 aa) FASTA scores: opt: 1303,
E(): 2.8e-72, (81.2% identity in 239 aa overlap). Also
similar to many dolichyl-phosphate mannose synthases and
hypothetical proteins e.g. O59263|PH1585 hypothetical 34.6
KDA protein from Pyrococcus horikoshii (313 aa), FASTA
scores: opt: 472, E(): 1.2e-21, (36.65% identity in 232 aa
overlap); Q9V152|PAB1971 dolichyl-phosphate mannose
synthase from Pyrococcus abyssi (287 aa), FASTA scores:
opt: 467, E(): 2.3e-21, (35.85% identity in 223 aa
overlap); Q58619|YC22_METJA|MJ1222 hypothetical protein
from Methanococcus jannaschii (243 aa), FASTA scores: opt:
400, E(): 2.4e-17, (33.35% identity in 228 aa overlap);
O26474|MTH374 dolichyl-phosphate mannose synthase related
protein from Methanobacterium thermoautotrophicum (291 aa)
FASTA scores: opt: 354, E(): 1.7e-14, (33.5% identity in
218 aa overlap); O26239|MTH136 dolichyl-phosphate mannose
synthase from Methanobacterium thermoautotrophicum (220
aa), FASTA scores: opt: 345, E(): 4.8e-14, (33.5% identity
in 221 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3631"
/db_xref="EnsemblGenomes-Tr:CCP46454"
/db_xref="GOA:O06376"
/db_xref="InterPro:IPR001173"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:O06376"
/protein_id="CCP46454.1"
/translation="MASKMDTETHYSDVWVVIPAFNEAAVIGKVVTDVRSVFDHVVCV
DDGSTDGTGDIARRSGAHLVRHPINLGQGAAIQTGIEYARKQPGAQVFATFDGDGQHR
VKDVAAMVDRLGAGDVDVVIGTRFGRPVGKASASRPPLMKRIVLQTGARLSRRGRRLG
LTDTNNGLRVFNKTVADGLNITMSGMSHATEFIMLIAENHWRVAEEPVEVLYTEYSKS
KGQPLLNGVNIIFDGFLRGRMPR"
gene 4071236..4071580
/locus_tag="Rv3632"
CDS 4071236..4071580
/codon_start=1
/transl_table=11
/locus_tag="Rv3632"
/product="Possible conserved membrane protein"
/note="Rv3632, (MTCY15C10.20c), len: 114 aa. Possible
conserved membrane protein, equivalent to
O69541|MLCB2548.23c|ML0208 hypothetical 12.9 KDA protein
(putative membrane protein) from Mycobacterium leprae (113
aa), FASTA scores: opt: 594, E(): 7.1e-35, (82.0% identity
in 111 aa overlap). A core mycobacterial gene; conserved
in mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3632"
/db_xref="EnsemblGenomes-Tr:CCP46455"
/db_xref="GOA:I6YGT7"
/db_xref="InterPro:IPR019277"
/db_xref="UniProtKB/TrEMBL:I6YGT7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46455.1"
/translation="MNWIQVLLIASIIGLLFYLLRSRRSARSRAWVKVGYVLFVLAGI
YAVLRPDDTTVVANWFGVRRGTDLMLYALVMAFSFTTLSTYMRFKDLELRYARIARAL
ALEGAQAPEQCR"
gene 4071791..4072666
/locus_tag="Rv3633"
CDS 4071791..4072666
/codon_start=1
/transl_table=11
/locus_tag="Rv3633"
/product="Conserved protein"
/note="Rv3633, (MTCY15C10.19c), len: 291 aa. Conserved
protein, similar to Q9X5S6|MMCH from Streptomyces
lavendulae (254 aa), FASTA scores: opt: 368, E():
3.2e-16,(35.05% identity in 194 aa overlap); Q9APW1
hypothetical 32.7 KDA protein from Pseudomonas aeruginosa
(295 aa),FASTA scores: opt: 359, E(): 1.3e-15, (37.65%
identity in 170 aa overlap); Q9APV4 hypothetical 34.1 KDA
protein from Pseudomonas aeruginosa (309 aa), FASTA
scores: opt: 316,E(): 7.6e-13, (28.65% identity in 262 aa
overlap). And some similarity to Q9HGD7|FUM9 FUM9P from
Gibberella moniliformis (300 aa), FASTA scores: opt: 254,
E(): 6.5e-09, (29.95% identity in 157 aa overlap); and
P47181|YJ9S_YEAST|YJR154W|J2240 hypothetical 39.0 KDA
protein from Saccharomyces cerevisiae (Baker's yeast) (346
aa), FASTA scores: opt: 190, E(): 8.5e-05, (26.75%
identity in 127 aa overlap). Also similar to
P71782|YF01_MYCTU|Rv1501|MT1550|MTCY277.23 from
Mycobacterium tuberculosis (273 aa), FASTA scores: opt:
286, E(): 5.5e-11, (27.5% identity in 280 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3633"
/db_xref="EnsemblGenomes-Tr:CCP46456"
/db_xref="GOA:P9WI89"
/db_xref="InterPro:IPR008775"
/db_xref="UniProtKB/Swiss-Prot:P9WI89"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46456.1"
/translation="MTQSSSVERLVGEIDEFGYTVVEDVLDADSVAAYLADTRRLERE
LPTVIANSTTVVKGLARPGHVPVDRVDHDWVRIDNLLLHGTRYEALPVHPKLLPVIEG
VLGRDCLLSWCMTSNQLPGAVAQRLHCDDEMYPLPRPHQPLLCNALIALCDFTADNGA
TQVVPGSHRWPERPSPPYPEGKPVEINAGDALIWNGSLWHTAAANRTDAPRPALTINF
CVGFVRQQVNQQLSIPRELVRCFEPRLQELIGYGLYAGKMGRIDWRPPADYLDADRHP
FLDAVADRLQTSVRL"
gene complement(4072667..4073611)
/gene="galE1"
/gene_synonym="rmlB2"
/locus_tag="Rv3634c"
CDS complement(4072667..4073611)
/codon_start=1
/transl_table=11
/gene="galE1"
/gene_synonym="rmlB2"
/locus_tag="Rv3634c"
/product="UDP-glucose 4-epimerase GalE1 (galactowaldenase)
(UDP-galactose 4-epimerase) (uridine diphosphate galactose
4-epimerase) (uridine diphospho-galactose 4-epimerase)"
/note="Rv3634c, (MTCY15C10.18), len: 314 aa.
GalE1,UDP-glucose 4-epimerase (see citations below),
equivalent to O69544|ML0204|RMLB2|MLCB2548.27c putative
sugar dehydratase (putative sugar-nucleotide dehydratase)
from Mycobacterium leprae (319 aa), FASTA scores: opt:
1798,E(): 8.2e-100, (86.4% identity in 309 aa overlap).
Also similar to other UDP-glucose 4-epimerases e.g.
Q9WYX9|TM0509 from Thermotoga maritima (309 aa) FASTA
scores: opt: 877, E(): 4.8e-45, (45.8% identity in 308 aa
overlap); Q57664|GALE_METJA|MJ0211 from Methanococcus
jannaschii (305 aa), FASTA scores: opt: 792, E():
5.4e-40,(42.05% identity in 309 aa overlap); Q9K6S7|BH3649
from Bacillus halodurans (311 aa), FASTA scores: opt: 723,
E(): 7e-36, (40.5% identity in 316 aa overlap);
Q9HSV1|GALE2|VNG0063G from Halobacterium sp. strain NRC-1
(328 aa), FASTA scores: opt: 597, E(): 2.3e-28, (36.35%
identity in 322 aa overlap); etc. Contains short-chain
alcohol dehydrogenase family signature (PS00061) but this
maynot be significant. Belongs to the sugar epimerase
family. Note that previously known as rmlB2, a
dTDP-glucose 4,6-dehydratase (see Ma et al., 2001)."
/db_xref="EnsemblGenomes-Gn:Rv3634c"
/db_xref="EnsemblGenomes-Tr:CCP46457"
/db_xref="GOA:P9WN67"
/db_xref="InterPro:IPR016040"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN67"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46457.1"
/translation="MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHL
ADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTV
RLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAGKVAGEIYLNTF
RHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFV
DDVVDAFVRVSADVGGGLRFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLK
RSCLDIGLAERVLGWRPQIELADGVRRTVEYFRHKHTD"
gene 4073634..4075409
/locus_tag="Rv3635"
CDS 4073634..4075409
/codon_start=1
/transl_table=11
/locus_tag="Rv3635"
/product="Probable conserved transmembrane protein"
/note="Rv3635, (MTCY15C10.17c), len: 591 aa (start
unclear). Probable conserved transmembrane
protein,equivalent, but longer 25 aa, to
O69545|ML0203|MLCB2548.28 putative membrane protein from
Mycobacterium leprae (569 aa), FASTA scores: opt: 2933,
E(): 4.6e-173, (77.0% identity in 569 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3635"
/db_xref="EnsemblGenomes-Tr:CCP46458"
/db_xref="GOA:I6Y460"
/db_xref="UniProtKB/TrEMBL:I6Y460"
/protein_id="CCP46458.1"
/translation="MPAPRMPRVALVAVLLITVQLVVRVVLAFGGYFYWDDLILVGRA
GTGGLLSPSYLFDDHDGHVMPGAFLVAGAIIRVAPLVWTGPAISLVVLQLLESLALLR
ALYVISSWRPVLLIPLTFALFTPLAVPGFAWWAAALNSLPMLAALAWVCADAILLVRT
GNHRYAVTGVLVYLGGLLFFEKAAVIPFVSFAVAALQCHVRGDRSALATVWRAGVRLW
TPSLALTVGWVALYLAVVDQRRWSSDLSMTWDLLCRSVTHGIVPALAGGPWDWARWAP
ASPWATPPAVVMVLGWLVLIAVLALSLVRKRRIGPVWLTAAGYAVACQVPIFLMRSSP
FTALELAQTLRYFPDLVVVLALLAAVALQAPNRAGTRWLDASPARAVATVASAVLFLT
SSLYSTATFLASWRDNPTEGYLKNAQASLAAAASGAPLLDQEVDPLVLQRVAWPENLA
SHMFALLRVRPEFATTTTQLRMFTSTGRLVDAKVTWVRTIIAGPVPQCGYFVQPDRPE
RLILDGPLLPGDWTVELNYLANSDGSMALALSDGPERKVPVHPGLNRVYARLPGAGDA
ITVRANTTALSLCIGAAPVGFLAPA"
mobile_element 4075615..4077750
/mobile_element_type="insertion sequence:IS1534"
/note="IS1534, len: 2136 nt. Putative Insertion sequence
element, IS1534 (IS15C10.2), that resembles IS21; possibly
defective."
repeat_region 4075615..4075630
/note="16 bp inverted repeat at the left end of putative
IS element IS1534; GAAAATTGACCAGCTT."
gene 4075752..4076099
/locus_tag="Rv3636"
CDS 4075752..4076099
/codon_start=1
/transl_table=11
/locus_tag="Rv3636"
/product="Possible transposase"
/note="Rv3636, (MTCY15C10.16c), len: 115 aa. Possible
transposase, weakly similar to others e.g. O69924|SC3C8.12
putative transposase from Streptomyces coelicolor (487 aa)
FASTA scores: opt: 132, E(): 0.12, (33.05% identity in 112
aa overlap); O96916 TC1-like transposase from Anopheles
gambiae (African malaria mosquito) (332 aa), FASTA scores:
opt: 117, E(): 0.84, (30.75% identity in 91 aa overlap);
Q9R2U5|IS466A|IS466A-ORF|TNPA|IS469|SCP1.276 transposase
(insertion element IS466S transposase) from Streptomyces
coelicolor (513 aa), FASTA scores: opt: 114, E(): 2,
(30.5% identity in 82 aa overlap); etc. Similar in part to
P96288|Rv2943|MTCY24G1.06c hypothetical 45.8 KDA protein
from Mycobacterium tuberculosis (413 aa), FASTA scores:
opt: 533, E(): 1.4e-28, (74.55% identity in 110 aa
overlap). Contains possible helix-turn-helix motif from aa
19-40 (+4.98 SD)."
/db_xref="EnsemblGenomes-Gn:Rv3636"
/db_xref="EnsemblGenomes-Tr:CCP46459"
/db_xref="InterPro:IPR036388"
/db_xref="UniProtKB/TrEMBL:O06371"
/protein_id="CCP46459.1"
/translation="MLSVEDWAEIRRLRRSERLPISEIARVLKISRNTVKSALASDGP
PKYQRAAKGSVADEAEPRIRELLAAYPRMPATVIAERIGWWYSIRTLSGRVRELRPLY
LPPDPASRDICGR"
gene 4076484..4076984
/locus_tag="Rv3637"
CDS 4076484..4076984
/codon_start=1
/transl_table=11
/locus_tag="Rv3637"
/product="Possible transposase"
/note="Rv3637, (MTCY15C10.15c), len: 166 aa. Possible
transposase. C-terminal end highly similar to Q9RLQ9|ISTA
putative transposase a (fragment) from Mycobacterium bovis
(102 aa), FASTA scores: opt: 397, E(): 1.4e-19, (58.8%
identity in 102 aa overlap). Weakly similar to others e.g.
Q9KJ02 putative transposase (fragment) from Polyangium
cellulosum (329 aa), FASTA scores: opt: 191, E():
1.6e-05,(32.1% identity in 134 aa overlap); Q9LCU2|ISTA
cointegrase from Pseudomonas aeruginosa (382 aa) FASTA
scores: opt: 144, E(): 0.024, (26.8% identity in 123 aa
overlap); P15025|ISTA_PSEAE transposase for insertion
sequence element IS21 from Pseudomonas aeruginosa (390
aa), FASTA scores: opt: 144, E(): 0.025, (26.85% identity
in 123 aa overlap); etc. Also highly similar to C-terminal
end of P96288|Rv2943|MTCY24G1.06c hypothetical 45.8 KDA
protein from Mycobacterium tuberculosis (413 aa) FASTA
scores: opt: 722, E(): 1.5e-40, (63.7% identity in 168 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3637"
/db_xref="EnsemblGenomes-Tr:CCP46460"
/db_xref="UniProtKB/TrEMBL:O06370"
/protein_id="CCP46460.1"
/translation="MPGRVFASPADFNTQLQAWLVRANHRQHRVLGCRPADRIEADTA
AMLTLPPVGPSIGWRTSTRLPRDHYVRLDGNDYSVHPVAIGRRIEITADLSRVRVWCG
GTLVADHDRIWAKHQTISDPEHVVAAKLLRRKRFDIVGPPHHVEVEQRLLTTYDTVLG
LDGPVA"
gene 4076984..4077730
/locus_tag="Rv3638"
CDS 4076984..4077730
/codon_start=1
/transl_table=11
/locus_tag="Rv3638"
/product="Possible transposase"
/note="Rv3638, (MTCY15C10.14c), len: 248 aa. Possible
transposase, highly similar to Q9RLQ8|ISTB ISTB protein
from Mycobacterium bovis (266 aa), FASTA scores: opt:
784,E(): 4e-46, (78.0% identity in 259 aa overlap); and
similar to others e.g. P15026|ISTB_PSEAE insertion
sequence IS21 putative ATP-binding protein from
Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 420,
E(): 2.2e-21, (38.8% identity in 255 aa overlap);
Q45619|ISTB_BACST insertion sequence IS5376 putative
ATP-binding protein from Bacillus stearothermophilus (251
aa), FASTA scores: opt: 402, E(): 3.6e-20, (34.5% identity
in 232 aa overlap); P15026|ISTB_ECOLI ISTB protein from
Escherichia coli (265 aa), FASTA scores: opt: 419, E():
8e-23, (38.8% identity in 255 aa overlap); etc. C-terminus
highly similar to C-terminus of P96287|Rv2944|MTCY24G1.05
hypothetical 25.5 KDA protein from Mycobacterium
tuberculosis strain H37Rv (alias AAK47343|MT3016 IS1533,
ORFB from Mycobacterium tuberculosis strain CDC1551) (238
aa), FASTA scores: opt: 784, E(): 3.6e-46, (87.4% identity
in 135 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3638"
/db_xref="EnsemblGenomes-Tr:CCP46461"
/db_xref="GOA:I6XHU7"
/db_xref="InterPro:IPR002611"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR028350"
/db_xref="UniProtKB/TrEMBL:I6XHU7"
/protein_id="CCP46461.1"
/translation="MAAKTATNSRDVAAELAYLTRALKAPTLRGAIEQLADRARTKTW
SYEEFLAACLQREVSARESHGGEGRIRAARFPSRKSLEEFDFDHARGLKRDTIAHLGT
LDFVTLAIGIAIRACQAGHRVLFATASQWVDRLAAAHHSGTLQSELIRLARYPLLVVD
EVGYIPFEPEAANLFFQLVSSRYERASLIVTSNKPFGRWGEVFGDDVVAAAMIDRLVH
HAEVIALKGDSYRIKDRDLGRVPTVTADDQ"
repeat_region complement(4077735..4077750)
/note="16 bp inverted repeat at the right end of putative
IS element IS1534; GAAAATTGACCAGCTT."
gene complement(4077884..4078450)
/locus_tag="Rv3639c"
CDS complement(4077884..4078450)
/codon_start=1
/transl_table=11
/locus_tag="Rv3639c"
/product="Conserved hypothetical protein"
/note="Rv3639c, (MTCY15C10.13), len: 188 aa. Hypothetical
protein, with C-terminus highly similar to N-terminus of
P95044|Rv0698|MTCY210.15 hypothetical 22.3 KDA protein
from Mycobacterium tuberculosis (203 aa), FASTA scores:
opt: 224, E(): 4.5e-07, (54.8% identity in 73 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3639c"
/db_xref="EnsemblGenomes-Tr:CCP46462"
/db_xref="UniProtKB/TrEMBL:I6YGU1"
/protein_id="CCP46462.1"
/translation="MAGLFTPPASGAATLQRAARDAAPDARWLLAVSDRNGIVSTSAT
TCNYPPAAKDSAQDGFRHALAAAIAADIDEALRHGYGDLLELAYPLMSWPRRGVFGGP
TPAPRGLATRQCPPRTVHVDRVRPNGAERALRARFRPILRPQFTLGDGANGLPLAACT
KTGAYVPHLPYSPIAVDPQPSAGQQGPS"
mobile_element complement(4078506..4079798)
/mobile_element_type="insertion sequence:IS1553"
/note="IS1553, len: 1293 nt. Putative Insertion sequence
element, IS1553."
repeat_region 4078506..4078518
/note="13 bp inverted repeat at the right end of putative
IS element IS1553; GAGTTCGTCGGTG."
gene complement(4078520..4079749)
/locus_tag="Rv3640c"
CDS complement(4078520..4079749)
/codon_start=1
/transl_table=11
/locus_tag="Rv3640c"
/product="Probable transposase"
/note="Rv3640c, (MTCY15C10.12), len: 409 aa. Probable
transposase, highly similar to others e.g. Q48882
transposase from Mycobacterium avium (411 aa) FASTA
scores: opt: 1574, E(): 6.2e-93, (59.75% identity in 400
aa overlap); Q9AKV5 putative transposase (fragment) from
Mycobacterium paratuberculosis (395 aa), FASTA scores:
opt: 1566, E(): 1.9e-92, (60.0% identity in 395 aa
overlap); Q48368 transposase from Mycobacterium avium (410
aa), FASTA scores: opt: 1561, E(): 4.1e-92, (59.4%
identity in 404 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3640c"
/db_xref="EnsemblGenomes-Tr:CCP46463"
/db_xref="GOA:O06367"
/db_xref="InterPro:IPR001207"
/db_xref="UniProtKB/TrEMBL:O06367"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46463.1"
/translation="MALPQSALSELLDAFRTGDGVDLIRDAVRLVLQELSELEATERI
GAARYERSDTRVTDRNGARSRVLSTQAGDVELRIPKLRKGSFFPAILEPRRRIDQALY
AVVMEAYVHGISTRAVDDLVEAMGVETGISKSEVSRICAGLDEIVGAFRTRTLGHIEF
PYVYLDATYLNVRNGTGQVVSMAVIVASGIAADGSREILGLDVGDSEDETFWRGFLTS
LKGRGLGGVRLVISDQHAGLVKALKRCFQGAGHQRCRVHFARNLLAHVPKDKADMVAS
MFRMIFSAPDAEAVHATWEGVRDRLAASFPKIGPLMDDARAEVLAFTAFPKAHWQKIW
STNPLERINKEIKRRSRVVGIFPNPAAVIRLVGAVLADMHDEWQASERRYLSEASMAL
LYPDSDNAVVAAISGGQ"
repeat_region complement(4079786..4079798)
/note="13 bp inverted repeat at the left end of putative
IS element IS1553; GAGATCGTCGGTG."
gene complement(4079925..4080560)
/gene="fic"
/locus_tag="Rv3641c"
CDS complement(4079925..4080560)
/codon_start=1
/transl_table=11
/gene="fic"
/locus_tag="Rv3641c"
/product="Possible cell filamentation protein Fic"
/note="Rv3641c, (MTCY15C10.11), len: 211 aa. Possible
fic,cell filamentation protein, similar to others e.g.
Q9PCU8|XF1657 cell filamentation protein from Xylella
fastidiosa (203 aa), FASTA scores: opt: 324, E():
2.2e-14,(32.8% identity in 189 aa overlap);
P20605|FIC_ECOLI|B3361 from Escherichia coli strain K12
(200 aa), FASTA scores: opt: 323, E(): 2.5e-14, (31.0%
identity in 187 aa overlap); P20751|FIC_SALTY from
Salmonella typhimurium (200 aa),FASTA scores: opt: 322,
E(): 2.9e-14, (32.65% identity in 193 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3641c"
/db_xref="EnsemblGenomes-Tr:CCP46464"
/db_xref="GOA:I6YCN3"
/db_xref="InterPro:IPR003812"
/db_xref="InterPro:IPR036597"
/db_xref="UniProtKB/TrEMBL:I6YCN3"
/protein_id="CCP46464.1"
/translation="MPHPWDTGDHERNWQGYFIPAMSVLRNRVGARTHAELRDAENDL
VEARVIELREDPNLLGDRTDLAYLRAIHRQLFQDIYVWAGDLRTVGIEKEDESFCAPG
GISRPMEHVAAEIYQLDRLRAVGEGDLAGQVAYRYDYVNYAHPFREGNGRSTREFFDL
LLSERGSGLDWGKTDLEELHGACHVARANSDLTGLVAMFKGILDAEPTYDF"
gene complement(4080571..4080765)
/locus_tag="Rv3642c"
CDS complement(4080571..4080765)
/codon_start=1
/transl_table=11
/locus_tag="Rv3642c"
/product="Hypothetical protein"
/note="Rv3642c, (MTCY15C10.10), len: 64 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3642c"
/db_xref="EnsemblGenomes-Tr:CCP46465"
/db_xref="InterPro:IPR041535"
/db_xref="UniProtKB/TrEMBL:I6Y464"
/protein_id="CCP46465.1"
/translation="MFVQATELQKVKRRFRNVRATRRNTELEGTRSTAATRADQNDYA
RGKITAAELGERVRRRYNIQ"
gene 4081160..4081351
/locus_tag="Rv3643"
CDS 4081160..4081351
/codon_start=1
/transl_table=11
/locus_tag="Rv3643"
/product="Hypothetical protein"
/note="Rv3643, (MTCY15C10.09c), len: 63 aa (questionable
ORF). Identical to AAK48106 from Mycobacterium
tuberculosis strain CDC1551 (33 aa) but longer 30 aa."
/db_xref="EnsemblGenomes-Gn:Rv3643"
/db_xref="EnsemblGenomes-Tr:CCP46466"
/db_xref="UniProtKB/TrEMBL:O06364"
/protein_id="CCP46466.1"
/translation="MERSIGLEAAAQQAGHSGSEITRRHYVERSVTVPDYTAALDEYS
RPIRAFRPLKSNRPGDIPT"
gene complement(4081365..4081437)
/gene="thrU"
tRNA complement(4081365..4081437)
/gene="thrU"
/product="tRNA-Thr"
/anticodon=(pos:complement(4081402..4081404),aa:Thr,
seq:cgt)
/note="codon recognized: ACG; thrU, tRNA-Thr, anticodon
cgt, length = 73"
gene complement(4081516..4082721)
/locus_tag="Rv3644c"
CDS complement(4081516..4082721)
/codon_start=1
/transl_table=11
/locus_tag="Rv3644c"
/product="Possible DNA polymerase"
/note="Rv3644c, (MTCY15C10.08), len: 401 aa. Possible DNA
polymerase, equivalent to O69546|MLCB2548.29c|ML0202
hypothetical 42.7 KDA protein from Mycobacterium leprae
(405 aa), FASTA scores: opt: 2180, E(): 6.1e-116, (84.4%
identity in 404 aa overlap). Similar (in totality or in
first 200 aa) to DNA polymerases III, delta' or gamma
subunit, e.g. Q9X906|SCH5.03c putative DNA polymerase from
Streptomyces coelicolor (401 aa), FASTA scores: opt:
1022,E(): 1.5e-50, (47.05% identity in 404 aa overlap);
Q9RRS5|DR2410 DNA polymerase III, tau/gamma subunit from
Deinococcus radiodurans (615 aa), FASTA scores: opt:
370,E(): 1.3e-13, (29.95% identity in 394 aa overlap);
P28631|HOLB_ECOLI|B1099 DNA polymerase III, delta' subunit
from Escherichia coli strain K12 (334 aa), FASTA scores:
opt: 345, E(): 2.2e-12, (33.45% identity in 239 aa
overlap); Q9JTS1|DNAZX|NMA1656 DNA polymerase III tau and
gamma chains from Neisseria meningitidis (serogroup A)
(709 aa), FASTA scores: opt: 346, E(): 3.3e-12, (28.55%
identity in 364 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3644c"
/db_xref="EnsemblGenomes-Tr:CCP46467"
/db_xref="GOA:O06363"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR004622"
/db_xref="InterPro:IPR008921"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O06363"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46467.1"
/translation="MSGVFTRLVGQQAVEAELLATAKAARRDSAHSAGGGGTMTHAWL
LTGPPGSGRSVAALCFAAALQCTSGGEPGCGRCRACTTTLAGTHADVRRVIPEGLSIG
VDEMRAIVQIAARRPTTGHWQIVVIEDADRLTEGAANALLKVVEEPPPSTVFLLCAPS
VDPEDIAVTLRSRCRHVALVTPSTHAIAQVLSDGDGLDPDTANWAASVSGGHVGRARR
LATDPQARQRRERALGLARDAATPSRAYAAAEELVAGAEAEALALTAQRIEAETEELR
TALGAGGTGKGTGAALRGATGAMKDLERRQKSRQTRASRDALDRALIDLATYFRDALL
VAAHAGGVRANHPDMADRVAALAAHAPPERLLRCIEAVLACREALAVNVKPKFAVDAM
VATIGQELR"
gene 4082807..4084456
/locus_tag="Rv3645"
CDS 4082807..4084456
/codon_start=1
/transl_table=11
/locus_tag="Rv3645"
/product="Probable conserved transmembrane protein"
/note="Rv3645, (MTCY15C10.07c), len: 549 aa. Probable
conserved transmembrane protein, equivalent, but longer 20
aa, to O69547|ML0201|MLCB2548.30 putative membrane protein
from Mycobacterium leprae (530 aa), FASTA scores: opt:
2958, E(): 1.5e-168, (85.5% identity in 530 aa overlap).
Also closely related to several other hypothetical M.
tuberculosis proteins, e.g.
Q10631|YD18_MYCTU|Rv1318c|MT1359|MTCY130.03c (541 aa)
FASTA scores: opt: 1105, E(): 2.7e-58, (39.35% identity in
506 aa overlap); Q10633|YD20_MYCTU|Rv1320c|MT1362|MTCY130.
05c (567 aa) FASTA scores: opt: 1031, E(): 7.1e-54, (38.1%
identity in 509 aa overlap);
Q10632|YD19_MYCTU|Rv1319c|MTCY130.04c (535 aa), FASTA
scores: opt: 1016, E(): 5.3e-53, (37.1% identity in 531 aa
overlap); etc. Also similar at C-terminal end to many
adenylate cyclases e.g. O83498|TP0485 from Treponema
pallidum (614 aa) FASTA scores: opt: 365, E(): 3.2e-14,
(31.55% identity in 317 aa overlap); P94180|CYAA from
Anabaena sp. strain PCC 7120 (735 aa), FASTA scores: opt:
364, E(): 4.2e-14, (32.75% identity in 229 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3645"
/db_xref="EnsemblGenomes-Tr:CCP46468"
/db_xref="GOA:I6X7Z3"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/TrEMBL:I6X7Z3"
/protein_id="CCP46468.1"
/translation="MDAEAFVGFRQVPAARYGGLMATTAALPRRIHAFVRWVVRTPWP
LFSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIILFLAGAVV
NLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLISLAVWATGGGVFILA
SWSVAKHAAPVVAVATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVNAPGVIL
RLMLAWIPSTGVPLLAIVLAVAADKIALLHATPEALFNPILMMALAALGIGSVSTLLV
AMSIADPLRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDL
FGRYVGEDVARRALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFR
VVVETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVLGSAEF
GIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDGHVLASAIAVSGALD
AEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVSSEVRG"
gene complement(4084453..4087257)
/gene="topA"
/locus_tag="Rv3646c"
CDS complement(4084453..4087257)
/codon_start=1
/transl_table=11
/gene="topA"
/locus_tag="Rv3646c"
/product="DNA topoisomerase I TopA (omega-protein)
(relaxing enzyme) (untwisting enzyme) (swivelase) (type I
DNA topoisomerase) (nicking-closing enzyme) (TOPO I)"
/note="Rv3646c, (MTCY15C10.06), len: 934 aa. TopA, DNA
topoisomerase I (see citations below), equivalent to
O69548|TOP1_MYCLE|TOPA|ML0200|MLCB2548.31c DNA
topoisomerase I from Mycobacterium leprae (947 aa) FASTA
scores: opt: 5150, E(): 0, (84.6% identity in 936 aa
overlap). Also highly similar to many e.g.
Q9X909|TOP1_STRCO|TOPA|SCH5.06c from Streptomyces
coelicolor (952 aa), FASTA scores: opt: 2754, E():
1.3e-153, (61.3% identity in 928 aa overlap);
P73810|TOP1_SYNY3|TOPA|SLR2058 from Synechocystis sp.
strain PCC 6803 (898 aa), FASTA scores: opt: 1442, E():
9.1e-77, (47.15% identity in 927 aa overlap);
P47368|TOP1_MYCGE|TOPA|MG122 from Mycoplasma genitalium
(709 aa), FASTA scores: opt: 865, E(): 4.8e-43, (30.3%
identity in 736 aa overlap);
P06612|TOP1_ECOLI|TOPA|SUPX|B1274 from Escherichia coli
strain K12 (865 aa), FASTA scores: opt: 397, E(): 0,
(39.6% identity in 704 aa overlap); etc. Belongs to
prokaryotic type I/III topoisomerase family."
/db_xref="EnsemblGenomes-Gn:Rv3646c"
/db_xref="EnsemblGenomes-Tr:CCP46469"
/db_xref="GOA:P9WG49"
/db_xref="InterPro:IPR000380"
/db_xref="InterPro:IPR003601"
/db_xref="InterPro:IPR003602"
/db_xref="InterPro:IPR005733"
/db_xref="InterPro:IPR006171"
/db_xref="InterPro:IPR013497"
/db_xref="InterPro:IPR013824"
/db_xref="InterPro:IPR013825"
/db_xref="InterPro:IPR013826"
/db_xref="InterPro:IPR023405"
/db_xref="InterPro:IPR023406"
/db_xref="InterPro:IPR025589"
/db_xref="InterPro:IPR028612"
/db_xref="InterPro:IPR034149"
/db_xref="PDB:5D5H"
/db_xref="PDB:5UJ1"
/db_xref="PDB:5UJY"
/db_xref="PDB:6CQ2"
/db_xref="PDB:6CQI"
/db_xref="UniProtKB/Swiss-Prot:P9WG49"
/inference="protein motif:PROSITE:PS00396"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46469.1"
/translation="MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVES
SRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKD
VDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDL
VDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAY
WDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGS
ATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRL
YENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAI
RPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGH
QEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDG
HATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAV
TGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGG
LKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRA
NLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPA
ADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGE
EITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRE
LGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPA
KRPARKAARKVPAKKAAKRD"
gene complement(4087610..4088188)
/locus_tag="Rv3647c"
CDS complement(4087610..4088188)
/codon_start=1
/transl_table=11
/locus_tag="Rv3647c"
/product="Conserved hypothetical protein"
/note="Rv3647c, (MTCY15C10.05), len: 192 aa. Conserved
hpothetical protein, equivalent to
O69549|MLCB2548.32c|ML0199 conserved hypothetical protein
from Mycobacterium leprae (200 aa), FASTA scores: opt:
1029, E(): 9e-58, (80.4% identity in 199 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3647c"
/db_xref="EnsemblGenomes-Tr:CCP46470"
/db_xref="UniProtKB/TrEMBL:I6Y469"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46470.1"
/translation="MSQLSFFAAESVPPAVADLSGVLAGPGQIVLVGCGARLSVVVAE
SWRASALAEMIQEAGLVPEVARTDENTPLVRTAVDPLLCGIAAEWTRGAVKTVPPRWL
PGPRELRAWTLAAGSPEADRYLLGLDPHAPDTHSPLASALMRVGIAPTLIGTRGTRPA
LRISGRRRLSRLVENVGEPPDGAEAWVQWPRT"
gene complement(4088328..4088531)
/gene="cspA"
/locus_tag="Rv3648c"
CDS complement(4088328..4088531)
/codon_start=1
/transl_table=11
/gene="cspA"
/locus_tag="Rv3648c"
/product="Probable cold shock protein A CspA"
/note="Rv3648c, (MTCY15C10.04), len: 67 aa. Probable
cspA,cold shock protein A, identical to
O69550|CSPB|CSPA|ML0198 small cold-shock protein from
Mycobacterium leprae (67 aa) FASTA scores: opt: 451, E():
3.7e-27, (97.0% identity in 67 aa overlap). Also highly
similar to many e.g. Q9KGW0|CSPA from Mycobacterium
smegmatis (67 aa) FASTA scores: opt: 439, E(): 2.9e-26,
(92.55% identity in 67 aa overlap); P54584|CSP_ARTGO from
Arthrobacter globiformis (67 aa),FASTA scores: opt: 335,
E(): 1.5e-18, (73.45% identity in 64 aa overlap);
O30875|CSPA_MICLU from Micrococcus luteus (Micrococcus
lysodeikticus); Q9Z5R4|CSPA_BORPE from Bordetella
pertussis (67 aa) FASTA scores: opt: 294, E(): 1.7e-15,
(59.7% identity in 67 aa overlap); etc. Contains
'cold-shock' DNA-binding domain signature (PS00352) at
N-terminal end. Belongs to the cold-shock domain (CSD)
family."
/db_xref="EnsemblGenomes-Gn:Rv3648c"
/db_xref="EnsemblGenomes-Tr:CCP46471"
/db_xref="GOA:P9WP75"
/db_xref="InterPro:IPR002059"
/db_xref="InterPro:IPR011129"
/db_xref="InterPro:IPR012156"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR019844"
/db_xref="UniProtKB/Swiss-Prot:P9WP75"
/inference="protein motif:PROSITE:PS00352"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46471.1"
/translation="MPQGTVKWFNAEKGFGFIAPEDGSADVFVHYTEIQGTGFRTLEE
NQKVEFEIGHSPKGPQATGVRSL"
gene 4088781..4091096
/locus_tag="Rv3649"
CDS 4088781..4091096
/codon_start=1
/transl_table=11
/locus_tag="Rv3649"
/product="Probable helicase"
/note="Rv3649, (MTCY15C10.03c), len: 771 aa. Probable
helicase, similar to many (known or hypothetical)
ATP-dependent helicases e.g. Q9X915|SCH5.13 putative
helicase from Streptomyces coelicolor (815 aa) FASTA
scores: opt: 2550, E(): 9.6e-139, (52.45% identity in 774
aa overlap); Q05549|YDR291W|D9819.1 protein similar to
several DNA helicases from Saccharomyces cerevisiae
(Baker's yeast) (1077 aa), FASTA scores: opt: 1161, E():
5.9e-59, (31.05% identity in 780 aa overlap);
P50830|YPRA_BACSU hypothetical helicase from Bacillus
subtilis (749 aa), FASTA scores: opt: 1154, E():
1.1e-58,(34.05% identity in 734 aa overlap); Q9KC10|BH1764
ATP-dependent RNA helicase from Bacillus halodurans (764
aa), FASTA scores: opt: 1122, E(): 8e-57, (32.3% identity
in 759 aa overlap); etc. Seems similar to dead/DEAH box
helicase family, and to helicase C-terminal domain."
/db_xref="EnsemblGenomes-Gn:Rv3649"
/db_xref="EnsemblGenomes-Tr:CCP46472"
/db_xref="GOA:O06359"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR018973"
/db_xref="InterPro:IPR022307"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O06359"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46472.1"
/translation="MASFGSHLLAAAVAGTPPGERPLRHVAELPPQAGRPRGWPEWAE
PDVVDAFADRGISSPWSHQAEAAELAYAGRHVVIGTGPASGKSLAYQLLVLNALATDS
RARALYLSPTKALGHDQLRAAHALAAAVPRLADVAPTAYDGDSPDEVRRFARERSRWL
FSNPEMTHLSVLRNHARWAVLLRNLRFVIVDECHYYRGVFGSNVAMVLRRLLRLCARY
SAHPTVIFASATTASPGATAADLIGQPVVEVTEDGSPRGARTVALWEPALRSDVIGEH
GAPVRRSAGAEAARVMADLIVEGAQTLTFVRSRRAAELTALGARARLVDIAPELSDTV
ASYRAGYLAEDRSALHQALAEGQLRGLATTNALELGVDIAGLDAVVLAGFPGTVASFW
QQAGRSGRRGQGALVVLIARDDPLDTYLVHHPAALLDKPVERVVIDPVNPHLLGPQLL
CAATELPLDDAEVRSWGAVEVAESLVDDGLLRRRNGRYFPAPGVKPHAAVDVRGAIGG
QIVIVEAGTGRLLGSVGVGQAPAAAHPGAVYLHQGETYVVDSLDFQDGIAFVHAEDPG
YATFAREVTDIAVTGTGERLVFGPVALGLVPVTVTNHVVGYLRRQLSGEVLDFVELDM
PEHTLPTTAVMYTITSDALVRSGIEATRIPGSLHAAEHAAIGLLPLVASCDRGDIGGM
STATGPEGLPSVFVYDGYPGGAGFAERGFRRARTWLGATAEAIEACECPSGCPSCVQS
PKCGNGNDPLDKAGAVRVLRLVLAELSEESP"
gene 4091233..4091517
/gene="PE33"
/locus_tag="Rv3650"
CDS 4091233..4091517
/codon_start=1
/transl_table=11
/gene="PE33"
/locus_tag="Rv3650"
/product="PE family protein PE33"
/note="Rv3650, (MTCY15C10.02c), len: 94 aa. PE33, Short
protein, member of the Mycobacterium tuberculosis PE
family (see Brennan and Delogu, 2002), but without the
repetitive gly-rich region, similar to the N-terminal part
of many e.g. O53809|Rv0746|MTV041.20 PGRS-family protein
(783 aa),FASTA scores: opt: 363, E(): 2.1e-15, (76.55%
identity in 81 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3650"
/db_xref="EnsemblGenomes-Tr:CCP46473"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:I6X7Z8"
/protein_id="CCP46473.1"
/translation="MSFVIAAPEALDSAATDLVVLGSTLGAATAAAAAQTTGIVAAAH
DEVSAAIAALFSAHGQAYQAASAQAAAFHTRFIRARSRHPQQETTCRRVR"
gene 4091841..4092878
/locus_tag="Rv3651"
CDS 4091841..4092878
/codon_start=1
/transl_table=11
/locus_tag="Rv3651"
/product="Conserved hypothetical protein"
/note="Rv3651, (MTCY15C10.01c), len: 345 aa. Hypothetical
protein, with some similarity to Q9ZHK1 hypothetical 36.5
KDA protein from Rhodococcus sp. X309 (329 aa) FASTA
scores: opt: 332, E(): 3.4e-13, (27.4% identity in 321 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3651"
/db_xref="EnsemblGenomes-Tr:CCP46474"
/db_xref="InterPro:IPR041439"
/db_xref="InterPro:IPR041458"
/db_xref="PDB:4Q6U"
/db_xref="UniProtKB/TrEMBL:I6YCP0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46474.1"
/translation="MTHDWLLVETLGDEPAVVARGRELKKLVPITTFLRRSPYLAAVR
TAIAETLQTGQSLTSITPKHDRVIRTEPVIMTDGRMHGVQVWSGPTDAEPPDRPIPGP
LKWDLTRGVATDTPESLTNSGKNPEVEITYGRAFAEDLPARELNPNETQVLAMAVKAK
PGKTLCSIWDLTDWQGTPIRIGFVARSALEPGPNGRDHLVARAMNWRAETKAPAVPVD
DLAQRILIGLAQAGVHRALVDLKTWTLLKWLDQPCSFYDWRRSAADGPRLHPDDQHVI
DAMTRDLANGSASHVLRLPGHDVDWVPVHVTVNRIELEPDTFAGLVALRLPTDEELAD
AGLPKATDVTT"
gene 4093468..4093522
/gene="mpr18"
ncRNA 4093468..4093522
/gene="mpr18"
/product="Fragment of putative small regulatory RNA"
/note="mpr18, fragment of putative small regulatory RNA
(See DiChiara et al., 2010), ends not mapped, 82 and 100
nt bands detected by Northern blot in M. bovis BCG
Pasteur."
/ncRNA_class="other"
gene 4093632..4093946
/gene="PE_PGRS60"
/locus_tag="Rv3652"
CDS 4093632..4093946
/codon_start=1
/transl_table=11
/gene="PE_PGRS60"
/locus_tag="Rv3652"
/product="PE-PGRS family-related protein PE_PGRS60"
/note="Rv3652, (MTV025.001A), len: 104 aa.
PE_PGRS60,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan
and Delogu,2002), similar at N-terminal end with many e.g.
P56877|Y278_MYCTU|Rv0278c|MTV035.06c (957 aa) FASTA
scores: opt: 242, E(): 3e-09, (77.35% identity in 53 aa
overlap). Originally annotated as the first part of a
PE-PGRS family protein (Rv3653/PE_PGRS61 being the second
part) but more similar to a PE family protein. Length
extended since first submission (+50 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3652"
/db_xref="EnsemblGenomes-Tr:CCP46475"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:Q6MWV1"
/protein_id="CCP46475.1"
/translation="MSYVIAAPEALVAAATDLATLGSTIGAANAAAAGSTTALLTAGA
DEVSAAIAAYSECTARPIRHSVRGRRRSMSGSCRPWPQVGAPMRPPRPPASRRCRARS
IC"
gene 4093940..4094527
/gene="PE_PGRS61"
/locus_tag="Rv3653"
CDS 4093940..4094527
/codon_start=1
/transl_table=11
/gene="PE_PGRS61"
/locus_tag="Rv3653"
/product="PE-PGRS family-related protein PE_PGRS61"
/note="Rv3653, (MTV025.001B), len: 195 aa.
PE_PGRS61,Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see Brennan
and Delogu,2002), highly similar to the C-termini of
members of the Mycobacterium tuberculosis PE family, PGRS
subfamily of gly-rich proteins, e.g. MTCY1A11_25,
MTCY28_25, MTCY130_10,MTCY1A10_19, MTCY21B4_13,
MTCI418B_6,MTCY28_34, MTV004_1,MTCY441_4; etc. Originally
annotated as the second part of a PE-PGRS family protein
(Rv3652/PE_PGRS60 being the first part). Start shortened
since first submission (-50 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3653"
/db_xref="EnsemblGenomes-Tr:CCP46476"
/db_xref="GOA:Q6MWV0"
/db_xref="UniProtKB/Swiss-Prot:Q6MWV0"
/protein_id="CCP46476.1"
/translation="MLNAPTQALLGRPLVGNGANGAPGTGANGGDGGILFGSGGAGGS
GAAGMAGGNGGAAGLFGNGGAGGAGGSATAGAAGAGGNGGAGGLLFGTAGAGGNGGLS
LGLGVAGGAGGAGGSGGSDTAGHGGTGGAGGLLFGAGEDGTTPGGNGGAGGVAGLFGD
GGNGGNAGVGTPAGNVGAGGTGGLLLGQDGMTGLT"
gene complement(4094660..4094914)
/locus_tag="Rv3654c"
CDS complement(4094660..4094914)
/codon_start=1
/transl_table=11
/locus_tag="Rv3654c"
/product="Conserved hypothetical protein"
/note="Rv3654c, (MTV025.002c), len: 84 aa. Hypothetical
protein, similar to C-terminus of Q9X916|SCH5.14c membrane
spanning protein from Streptomyces coelicolor (230 aa)
FASTA scores: opt: 176, E(): 2.4e-05, (47.0% identity in
83 aa overlap). Equivalent to AAK48118 from Mycobacterium
tuberculosis strain CDC1551 but shorter 18 aa."
/db_xref="EnsemblGenomes-Gn:Rv3654c"
/db_xref="EnsemblGenomes-Tr:CCP46477"
/db_xref="GOA:O69622"
/db_xref="InterPro:IPR021202"
/db_xref="UniProtKB/Swiss-Prot:O69622"
/protein_id="CCP46477.1"
/translation="MVARHRAQAAADLASLAAAARLPSGLAAACARATLVARAMRVEH
AQCRVVDLDVVVTVEVAVAFAGVATATARAGPAKVPTTPG"
gene complement(4094923..4095300)
/locus_tag="Rv3655c"
CDS complement(4094923..4095300)
/codon_start=1
/transl_table=11
/locus_tag="Rv3655c"
/product="Conserved hypothetical protein"
/note="Rv3655c, (MTV025.003c), len: 125 aa. Hypothetical
protein, with similarity to Q9X917|SCH5.15c hypothetical
15.2 KDA protein from Streptomyces coelicolor (150 aa)
FASTA scores: opt: 211, E(): 7.7e-07, (39.65% identity in
111 aa overlap). Equivalent to AAK48119 from Mycobacterium
tuberculosis strain CDC1551 (99 aa) but longer 26 aa at
the C-terminus."
/db_xref="EnsemblGenomes-Gn:Rv3655c"
/db_xref="EnsemblGenomes-Tr:CCP46478"
/db_xref="GOA:O69623"
/db_xref="UniProtKB/Swiss-Prot:O69623"
/protein_id="CCP46478.1"
/translation="MEAALAIATLVLVLVLCLAGVTAVSMQVRCIDAAREAARLAARG
DVRSATDVARSIAPRAALVQVHRDGEFVVATVTAHSNLLPTLDIAARAISVAEPGSTA
ARPPCLPSRWSRCCCASPVRVHI"
gene complement(4095324..4095530)
/locus_tag="Rv3656c"
CDS complement(4095324..4095530)
/codon_start=1
/transl_table=11
/locus_tag="Rv3656c"
/product="Conserved hypothetical protein"
/note="Rv3656c, (MTV025.004c), len: 68 aa. Conserved
hypothetical protein, similar to Q9X918|SCH5.16c small
hypothetical protein from Streptomyces coelicolor (75
aa),FASTA scores: opt: 129, E(): 0.0039, (40.0% identity
in 60 aa overlap). Equivalent to AAK48120 from
Mycobacterium tuberculosis strain CDC1551 (42 aa) but
longer 26 aa."
/db_xref="EnsemblGenomes-Gn:Rv3656c"
/db_xref="EnsemblGenomes-Tr:CCP46479"
/db_xref="GOA:O69624"
/db_xref="InterPro:IPR025338"
/db_xref="UniProtKB/TrEMBL:O69624"
/protein_id="CCP46479.1"
/translation="MLVITMFRVLVARMTALAVDESGMSTVEYAIGTIAAAAFGAILY
TVVTGDSIVSALNRIIGRALSTKV"
gene complement(4095540..4096115)
/locus_tag="Rv3657c"
CDS complement(4095540..4096115)
/codon_start=1
/transl_table=11
/locus_tag="Rv3657c"
/product="Possible conserved alanine rich membrane
protein"
/note="Rv3657c, (MTV025.005c), len: 191 aa. Possible
conserved membrane protein, rich in ala residues, similar
to Q9X919|SCH5.17c putative integral membrane protein from
Streptomyces coelicolor (267 aa), FASTA scores: opt:
324,E(): 4.7e-12, (40.9% identity in 154 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3657c"
/db_xref="EnsemblGenomes-Tr:CCP46480"
/db_xref="GOA:O69625"
/db_xref="InterPro:IPR018076"
/db_xref="UniProtKB/TrEMBL:O69625"
/protein_id="CCP46480.1"
/translation="MALWLGAGPSVVRARAGRPPRAHRPHQGLLLGRTDVADPLAVAA
SLDVLAVCLAAGMAVSTAAAATAAVAPPRLARVLRRAADLLALGADPNIAWSRPPDLP
PGTHDAQTDAVLRLARRSAASGAALADGIVELAVQVRHDAAQAAAAAAERAGVLIAGP
LGLCFLPAFLCVGIVPLVVGLAGDVLQFGLV"
gene complement(4096139..4096939)
/locus_tag="Rv3658c"
CDS complement(4096139..4096939)
/codon_start=1
/transl_table=11
/locus_tag="Rv3658c"
/product="Probable conserved transmembrane protein"
/note="Rv3658c, (MTV025.006c), len: 266 aa. Probable
conserved transmembrane protein, similar to
Q9X920|SCH5.18c putative integral membrane protein from
Streptomyces coelicolor (321 aa), FASTA scores: opt: 335,
E(): 4.1e-13,(38.05% identity in 247 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3658c"
/db_xref="EnsemblGenomes-Tr:CCP46481"
/db_xref="GOA:I6Y479"
/db_xref="InterPro:IPR018076"
/db_xref="UniProtKB/TrEMBL:I6Y479"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46481.1"
/translation="MSGIASAALILSLALVVLPGSPRCRLTPDDTGRRVLLVGARRVA
WGVGCVAVGVAALLPLPTVVAVAVLGATLGLRYRRRRRYLRRSREGQALEAALELVVG
ELRAGAHPVRAFSIAADETGGPVAVALRAVAARARLGADVTAGLLAAARSSALPAYWE
RLAVCWQLGSDHGLAIASLMRAAQRDVAERQRFSARVSAGMAGARASAAILAILPLLG
VLLGQLIGARPLSFLLTGRVGGWLLVVGLTLACAGLLWSDRITDRPVL"
gene complement(4096936..4097994)
/gene_synonym="trbB"
/locus_tag="Rv3659c"
CDS complement(4096936..4097994)
/codon_start=1
/transl_table=11
/gene_synonym="trbB"
/locus_tag="Rv3659c"
/product="Conserved hypothetical protein"
/note="Rv3659c, (MTV025.007c), len: 352 aa. Conserved
hypothetical protein, highly similar, but always shorter
(various lengths) at N-terminus, to Q9X921|SCH5.19c
putative secretory protein from Streptomyces coelicolor
(523 aa), FASTA scores: opt: 1287, E(): 5.3e-66, (59.85%
identity in 351 aa overlap); Q9HW98|PA4302 probable type
II secretion system protein from Pseudomonas aeruginosa
(421 aa), FASTA scores: opt: 776, E(): 5.4e-37, (42.8%
identity in 320 aa overlap); AAK65510|CPAF2 probable CPAF2
PILUS assembly protein from Rhizobium meliloti
(Sinorhizobium meliloti) plasmid pSymA (497 aa) FASTA
scores: opt: 769,E(): 1.5e-36, (40.45% identity in 309 aa
overlap); Q9KY93|SCK15.11 putative secretory protein from
Streptomyces coelicolor (445 aa), FASTA scores: opt:
751,E(): 1.5e-35, (38.15% identity in 333 aa overlap);
etc. Contains PS00017 ATP/GTP binding site motif A
(P-loop). Note that previously known as trbB."
/db_xref="EnsemblGenomes-Gn:Rv3659c"
/db_xref="EnsemblGenomes-Tr:CCP46482"
/db_xref="GOA:P9WMT3"
/db_xref="InterPro:IPR001482"
/db_xref="InterPro:IPR022399"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WMT3"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP46482.1"
/translation="MLGDTEVLANLRVLQTELTGAGILEPLLSADGTTDVLVTAPDSV
WVDDGNGLRRSQIRFADESAVRRLAQRLALAAGRRLDDAQPWVDGQLTGIGVGGFAVR
LHAVLPPVATQGTCLSLRVLRPATQDLAALAAAGAIDPAAAALVADIVTARLAFLVCG
GTGAGKTTLLAAMLGAVSPDERIVCVEDAAELAPRHPHLVKLVARRANVEGIGEVTVR
QLVRQALRMRPDRIVVGEVRGAEVVDLLAALNTGHEGGAGTVHANNPGEVPARMEALG
ALGGLDRAALHSQLAAAVQVLLHVARDRAGRRRLAEIAVLRQAEGRVQAVTVWHADRG
MSDDAAALHDLLRSRASA"
gene complement(4098096..4099148)
/locus_tag="Rv3660c"
CDS complement(4098096..4099148)
/codon_start=1
/transl_table=11
/locus_tag="Rv3660c"
/product="Conserved hypothetical protein"
/note="Rv3660c, (MTV025.008c), len: 350 aa. Conserved
hypothetical protein, similar to O33612 protein concerned
in inhibition of morphological differentiation in
Streptomyces azureus from Streptomyces cyaneus
(Streptomyces curacoi) (370 aa), FASTA scores: opt:
655,E(): 5.9e-31, (42.2% identity in 315 aa overlap);
Q9X922|SCH5.20c putative septum site determining protein
from Streptomyces coelicolor (396 aa), FASTA scores: opt:
592, E(): 2.9e-27, (43.25% identity in 275 aa overlap).
And shows some similarity to AAK65513|CPAE2 probable CPAE2
PILUS assembly protein from Rhizobium meliloti
(Sinorhizobium meliloti) plasmid pSymA (586 aa) FASTA
scores: opt: 212, E(): 5.1e-05, (25.75% identity in 295 aa
overlap); and several cell division inhibitors or septum
site-determining proteins. Equivalent to AAK48124 from
Mycobacterium tuberculosis strain CDC1551 (261 aa) but
longer 89 aa."
/db_xref="EnsemblGenomes-Gn:Rv3660c"
/db_xref="EnsemblGenomes-Tr:CCP46483"
/db_xref="GOA:P9WKX7"
/db_xref="InterPro:IPR022521"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WKX7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46483.1"
/translation="MLTDPGLRDELDRVAAAVGVRVVHLGGRHPVSRKTWSAAAAVVL
DHAAADRCGRLALPRRTHVSVLTGTEAATATWAAAITVGAQHVLRMPEQEGELVRELA
EAAESARDDGICGAVVAVIGGRGGAGASLFAVALAQAAADALLVDLDPWAGGIDLLVG
GETAPGLRWPDLALQGGRLNWSAVRAALPRPRGISVLSGTRRGYELDAGPVDAVIDAG
RRGGVTVVCDLPRRLTDATQAALDAADLVVLVSPCDVRACAAAATMAPVLTAINPNLG
LVVRGPSPGGLRAAEVADVAGVPLLASMRAQPRLAEQLEHGGLRLRRRSVLASAARRV
LGVLPRAGSGRHGRAA"
gene complement(4099386..4099478)
/gene="B11"
/gene_synonym="mpr19"
ncRNA complement(4099386..4099478)
/gene="B11"
/gene_synonym="mpr19"
/product="Putative small regulatory RNA"
/note="B11, putative small regulatory RNA (See Arnvig and
Young, 2009; DiChiara et al., 2010)."
/ncRNA_class="other"
gene 4099647..4100510
/locus_tag="Rv3661"
CDS 4099647..4100510
/codon_start=1
/transl_table=11
/locus_tag="Rv3661"
/product="Conserved hypothetical protein"
/note="Rv3661, (MTV025.009), len: 287 aa. Conserved
hypothetical protein, highly similar to O33611|IMD_STRCN
from Streptomyces cyaneus (Streptomyces curacoi) protein
involved in inhibition of morphological differentiation in
Streptomyces azureus (belongs to the SerB family) (277 aa)
FASTA scores: opt: 1073, E(): 3.5e-61, (61.45% identity in
262 aa overlap); and Q9X923|SCH5.21 putative morphological
differentiation-associated protein from Streptomyces
coelicolor (268 aa), FASTA scores: opt: 1057, E():
3.6e-60,(61.45% identity in 262 aa overlap). Also similar
to various bacterial proteins (principally serB-related
proteins) e.g. Q49823|ML2424 hypothetical SERB protein
from Mycobacterium leprae (300 aa), FASTA scores: opt:
452, E(): 1.4e-21, (35.8% identity in 257 aa overlap);
Q9WX12|SCE68.20 hypothetical 32.0 KDA protein from
Streptomyces coelicolor (298 aa), FASTA scores: opt:
415,E(): 3.1e-19, (33.55% identity in 280 aa overlap);
Q9RIT2|SERB phosphoserine phosphatase (fragment) from
Streptomyces coelicolor (266 aa), FASTA scores: opt:
405,E(): 1.2e-18, (34.1% identity in 261 aa overlap); etc.
Also similar to Q11169|Y505_MYCTU|Rv0505c|MTCY20G9.32c
hypothetical 39.5 KDA protein from Mycobacterium
tuberculosis (373 aa), FASTA scores: opt: 454, E():
1.2e-21, (35.15% identity in 276 aa overlap). Belongs to
the SerB family."
/db_xref="EnsemblGenomes-Gn:Rv3661"
/db_xref="EnsemblGenomes-Tr:CCP46484"
/db_xref="GOA:P9WGJ1"
/db_xref="InterPro:IPR006385"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WGJ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46484.1"
/translation="MTVSDSPAQRQTPPQTPGGTAPRARTAAFFDLDKTIIAKSSTLA
FSKPFFAQGLLNRRAVLKSSYAQFIFLLSGADHDQMDRMRTHLTNMCAGWDVAQVRSI
VNETLHDIVTPLVFAEAADLIAAHKLCGRDVVVVSASGEEIVGPIARALGATHAMATR
MIVEDGKYTGEVAFYCYGEGKAQAIRELAASEGYPLEHCYAYSDSITDLPMLEAVGHA
SVVNPDRGLRKEASVRGWPVLSFSRPVSLRDRIPAPSAAAIATTAAVGISALAAGAVT
YALLRRFAFQP"
gene 4100669..4100968
/gene="MTS2823"
ncRNA 4100669..4100968
/gene="MTS2823"
/product="Putative small regulatory RNA"
/note="MTS2823, putative small regulatory RNA (See Arnvig
et al., 2011), 5'-end mapped by RLM-RACE, 3'-end not
mapped, ~300 bp and ~250 bp bands detected by Northern
blot."
/ncRNA_class="other"
gene complement(4101265..4102035)
/locus_tag="Rv3662c"
CDS complement(4101265..4102035)
/codon_start=1
/transl_table=11
/locus_tag="Rv3662c"
/product="Conserved hypothetical protein"
/note="Rv3662c, (MTV025.010c), len: 256 aa. Conserved
hypothetical protein, equivalent to Q9CB99|ML2289
hypothetical protein from Mycobacterium leprae (256 aa)
FASTA scores: opt: 1255, E(): 3.3e-69, (78.05% identity in
255 aa overlap). Also similar to Q9X924|SCH5.22c putative
oxidoreductase from Streptomyces coelicolor (274 aa),
FASTA scores: opt: 289, E(): 1.8e-10, (39.25% identity in
270 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3662c"
/db_xref="EnsemblGenomes-Tr:CCP46485"
/db_xref="InterPro:IPR003812"
/db_xref="UniProtKB/TrEMBL:I6YCP7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46485.1"
/translation="MTVDPLAPLMELPGVAAASDRVRDALSRVHRHRANLRGWPVAAA
EASLRAARASSVLDGGPARLHDAGAPTSGKPALSDPVFAGALRVGQALEGGAGPVVGV
WRRAPLQALARLHMLAAADQVDDDRLGRPRSDADVGPRLELLADVVTHPTLASAPVVA
AVAHGELLTLRPFGCADGVVARAVSRLVTIATGLDPHGLGVPEVIWMRQPAEYHDAAR
RFAGGTPDGVAGWLLLCCGAMLDGAREALSIAESLSPG"
gene complement(4102032..4103678)
/gene="dppD"
/locus_tag="Rv3663c"
CDS complement(4102032..4103678)
/codon_start=1
/transl_table=11
/gene="dppD"
/locus_tag="Rv3663c"
/product="Probable dipeptide-transport ATP-binding protein
ABC transporter DppD"
/note="Rv3663c, (MTV025.011c), len: 548 aa. Probable
dppD,dipeptide-transport ATP-binding protein
ABC-transporter (see citation below), similar to many
ATP-binding proteins e.g. AAK65441|SMA1434 probable ABC
transporter ATP-binding protein from Rhizobium meliloti
(Sinorhizobium meliloti) plasmid pSymA (550 aa), FASTA
scores: opt: 1528, E(): 1e-78, (46.25% identity in 545 aa
overlap); O50270|MOAD MOAD protein from Agrobacterium
radiobacter (588 aa), FASTA scores: opt: 1354, E():
6.7e-69, (42.9% identity in 541 aa overlap);
Q9KM01|VCA0588 putative peptide ABC transporter
ATP-binding protein from Vibrio cholerae (530 aa), FASTA
scores: opt: 951, E(): 3.1e-46, (44.0% identity in 534 aa
overlap); BAB49448|MLR2279 ATP-binding protein of peptide
ABC transporter from Rhizobium loti (Mesorhizobium loti)
(604 aa), FASTA scores: opt: 949, E(): 4.4e-46, (41.55%
identity in 544 aa overlap); etc. Contains 2 PS00211 ABC
transporters family signature, and 2 PS00017
ATP/GTP-binding site motif A (P-loop). Belongs to the
ATP-binding transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv3663c"
/db_xref="EnsemblGenomes-Tr:CCP46486"
/db_xref="GOA:I6Y482"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR013563"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:I6Y482"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46486.1"
/translation="MSVPAAPLLSVEGLEVTFGTDAPAVCGVDLAVRSGQTVAVVGES
GSGKSTTAAAILGLLPAGGRITAGRVVFDGRDITGADAKRLRSIRGREIGYVPQDPMT
NLNPVWKVGFQVTEALRANTDGRAARRRAVELLAEAGLPDPAKQAGRYPHQLSGGMCQ
RALIAIGLAGRPRLLIADEPTSALDVTVQRQVLDHLQGLTDELGTALLLITHDLALAA
QRAEAVVVVRRGVVVESGAAQSILQSPQHEYTRRLVAAAPSLTARSRRPPESRSRATT
QAGDILVVSELTKIYRESRGAPWRRVESRAVDGVSFRLPRASTLAIVGESGSGKSTLA
RMVLGLLQPTSGTVVFDGTYDVGALARDQVLAFRRRVQPVFQNPYSSLDPMYSVFRAI
EEPLRVHHVGDRRQRQRAVRELVDQVALPSSILGRRPRELSGGQRQRVAIARALALRP
EVLVCDEAVSALDVLVQAQILDLLADLQADLGLTYLFISHDLAVIRQIADDVLVMRAG
RVVEHASTEEVFSRPRHEYTRQLLQAIPGAPSAPRKVGNL"
gene complement(4103675..4104475)
/gene="dppC"
/locus_tag="Rv3664c"
CDS complement(4103675..4104475)
/codon_start=1
/transl_table=11
/gene="dppC"
/locus_tag="Rv3664c"
/product="Probable dipeptide-transport integral membrane
protein ABC transporter DppC"
/note="Rv3664c, (MTV025.012c), len: 266 aa. Probable
dppC,dipeptide-transport integral membrane protein
ABC-transporter (see Braibant et al., 2000), similar to
many peptide permeases e.g. Q9F351|SC9E12.04 putative
peptide transport system integral membrane from
Streptomyces coelicolor (305 aa), FASTA scores: opt:
901,E(): 1.1e-47, (51.15% identity in 262 aa overlap);
Q9KFX1|APPC|BH0349 oligopeptide ABC transporter (permease)
from Bacillus halodurans (305 aa), FASTA scores: opt:
652,E(): 1.5e-32, (35.55% identity in 270 aa overlap);
P94312|DPPC_BACFI dipeptide transport system permease
protein from Bacillus firmus (304 aa), FASTA scores: opt:
642, E(): 5.9e-32, (35.75% identity in 263 aa overlap);
P24139|OPPC_BACSU|SPO0KC oligopeptide transport system
permease protein from Bacillus subtilis (305 aa), FASTA
scores: opt: 637, E(): 1.2e-31, (37.4% identity in 262 aa
overlap); P26904|DPPC_BACSU|DCIAC dipeptide transport
system permease protein from Bacillus subtilis (320
aa),FASTA scores: opt: 621, E(): 1.2e-30, (39.9% identity
in 263 aa overlap); etc. Has similarity with integral
membrane components of other binding-protein-dependent
transport systems. Belongs to the OPPBC subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3664c"
/db_xref="EnsemblGenomes-Tr:CCP46487"
/db_xref="GOA:L0TEV4"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:L0TEV4"
/protein_id="CCP46487.1"
/translation="MIAAALILLILVVAAFPSLFTAADPTYADPSQSMLAPSAAHWFG
TDLQGHDIYSRTVYGARASVTVGLGATLAVFVVGGALGALAGFYGSWIDAVVSRVTDV
FLGLPLLLAAIVLMQVMHHRTVWTVIAILALFGWPQVARIARGAVLEVRASDYVLAAK
ALGLNRFQILLRHALPNAVGPVIAVATVALGIFIVTEATLSYLGVGLPTSVVSWGGDI
NVAQTRLRSGSPILFYPAGALAITVLAFMMMGDALRDALDPASRAWRA"
gene complement(4104531..4105457)
/gene="dppB"
/locus_tag="Rv3665c"
CDS complement(4104531..4105457)
/codon_start=1
/transl_table=11
/gene="dppB"
/locus_tag="Rv3665c"
/product="Probable dipeptide-transport integral membrane
protein ABC transporter DppB"
/note="Rv3665c, (MTV025.013c), len: 308 aa. Probable
dppB,dipeptide-transport integral membrane protein
ABC-transporter (see citation below), similar to many
peptide permeases e.g. Q9F352|SC9E12.03 putative peptide
transport system integral membrane protein from
Streptomyces coelicolor (307 aa), FASTA scores: opt:
1145,E(): 1.8e-61, (57.65% identity in 307 aa overlap);
Q53191|Y4TP_RHISN probable peptide ABC transporter
permease protein Rhizobium sp. strain NGR234 (313 aa),
FASTA scores: opt: 653, E(): 5.2e-32, (31.2% identity in
314 aa overlap); P24138|OPPB_BACSU oligopeptide transport
system permease from Bacillus subtilis (311 aa), FASTA
scores: opt: 643,E(): 2.1e-31, (33.45% identity in 305 aa
overlap); etc. Belongs to the OPPBC subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3665c"
/db_xref="EnsemblGenomes-Tr:CCP46488"
/db_xref="GOA:I6YGV9"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:I6YGV9"
/protein_id="CCP46488.1"
/translation="MGWYVARRVAVMVPVFLGATLLIYGMVFLLPGDPVAALAGDRPL
TPAVAAQLRSHYHLDDPFLVQYLRYLGGILHGDLGRAYSGLPVSAVLAHAFPVTIRLA
LIALAVEAVLGIGFGVIAGLRQGGIFDSAVLVTGLVIIAIPIFVLGFLAQFLFGVQLE
IAPVTVGERASVGRLLLPGIVLGAMSFAYVVRLTRSAVAANAHADYVRTATAKGLSRP
RVVTVHILRNSLIPVVTFLGADLGALMGGAIVTEGIFNIHGVGGVLYQAVTRQETPTV
VSIVTVLVLIYLITNLLVDLLYAALDPRIRYG"
gene complement(4105459..4107084)
/gene="dppA"
/locus_tag="Rv3666c"
CDS complement(4105459..4107084)
/codon_start=1
/transl_table=11
/gene="dppA"
/locus_tag="Rv3666c"
/product="Probable periplasmic dipeptide-binding
lipoprotein DppA"
/note="Rv3666c, (MTV025.014c), len: 541 aa. Probable
dppA,dipeptide-binding lipoprotein component of dipeptide
transport system (see citation below), similar to many
substrate-binding proteins e.g. Q9F353|SC9E12.02 putative
peptide transport system secreted peptide-binding protein
from Streptomyces coelicolor (544 aa), FASTA scores: opt:
1200, E(): 9e-67, (39.2% identity in 538 aa overlap);
P24141|OPPA_BACSU oligopeptide-binding protein from
Bacillus subtilis (545 aa), FASTA scores: opt: 523, E():
7.9e-25, (26.15% identity in 516 aa overlap);
P23843|OPPA_ECOLI periplasmic oligopeptide-binding protein
from Escherichia coli (543 aa), FASTA scores: opt:
452,E(): 2e-20, (25.9% identity in 529 aa overlap); etc.
Contains probable N-terminal signal sequence."
/db_xref="EnsemblGenomes-Gn:Rv3666c"
/db_xref="EnsemblGenomes-Tr:CCP46489"
/db_xref="GOA:I6X811"
/db_xref="InterPro:IPR000914"
/db_xref="InterPro:IPR030678"
/db_xref="InterPro:IPR039424"
/db_xref="UniProtKB/TrEMBL:I6X811"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46489.1"
/translation="MVRQMRAALAALATGLLVLAPVAGCGGGVLSPDVVLVNGGEPPN
PLIPTGTNDSNGGRIIDRLFAGLMSYDAVGKPSLEVAQSIESADNVNYRITVKPGWKF
TDGSPVTAHSFVDAWNYGALSTNAQLQQHFFSPIEGFDDVAGAPGDKSRTTMSGLRVV
NDLEFTVRLKAPTIDFTLRLGHSSFYPLPDSAFRDMAAFGRNPIGNGPYKLADGPAGP
AWEHNVRIDLVPNPDYHGNRKPRNKGLRFEFYANLDTAYADLLSGNLDVLDTIPPSAL
TVYQRDLGDHATSGPAAINQTLDTPLRLPHFGGEEGRLRRLALSAAINRPQICQQIFA
GTRSPARDFTARSLPGFDPNLPGNEVLDYDPQRARRLWAQADAISPWSGRYAIAYNAD
AGHRDWVDAVANSIKNVLGIDAVAAPQPTFAGFRTQITNRAIDSAFRAGWRGDYPSMI
EFLAPLFTAGAGSNDVGYINPEFDAALAAAEAAPTLTESHELVNDAQRILFHDMPVVP
LWDYISVVGWSSQVSNVTVTWNGLPDYENIVKA"
gene 4107792..4109747
/gene="acs"
/locus_tag="Rv3667"
CDS 4107792..4109747
/codon_start=1
/transl_table=11
/gene="acs"
/locus_tag="Rv3667"
/product="Acetyl-coenzyme A synthetase Acs (acetate--CoA
ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase)
(acyl-activating enzyme) (acetate thiokinase)
(acetyl-activating enzyme) (acetate--coenzyme A ligase)
(acetyl-coenzyme A synthase)"
/note="Rv3667, (MTV025.015), len: 651 aa. Probable
acs,acetyl-coenzyme-a synthetase, similar to many e.g.
Q9X928|SCH5.26 from Streptomyces coelicolor (651 aa) FASTA
scores: opt: 2850, E(): 1.9e-164, (66.05% identity in 639
aa overlap); Q55404|ACSA_SYNY3|ACS|SLL0542 from
Synechocystis sp. strain PCC 6803 (653 aa), FASTA scores:
opt: 2342, E(): 8.8e-134, (55.15% identity in 649 aa
overlap); P31638|ACSA_ALCEU|ACOE from Alcaligenes
eutrophus (Ralstonia eutropha) (660 aa), FASTA scores:
opt: 2181,E(): 4.6e-124, (52.05% identity in 665 aa
overlap); P27550|ACSA_ECOLI|ACS|B4069 from Escherichia
coli strain K12 (652 aa), FASTA scores: opt: 1625, E(): 0,
(48.3% identity in 646 aa overlap); etc. Contains PS00455
Putative AMP-binding domain signature. Belongs to the
ATP-dependent AMP-binding enzyme family."
/db_xref="EnsemblGenomes-Gn:Rv3667"
/db_xref="EnsemblGenomes-Tr:CCP46490"
/db_xref="GOA:P9WQD1"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR011904"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR032387"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQD1"
/inference="protein motif:PROSITE:PS00455"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46490.1"
/translation="MSESTPEVSSSYPPPAHFAEHANARAELYREAEEDRLAFWAKQA
NRLSWTTPFTEVLDWSGAPFAKWFVGGELNVAYNCVDRHVEAGHGDRVAIHWEGEPVG
DRRTLTYSDLLAEVSKAANALTDLGLVAGDRVAIYLPLIPEAVIAMLACARLGIMHSV
VFGGFTAAALQARIVDAQAKLLITADGQFRRGKPSPLKAAADEALAAIPDCSVEHVLV
VRRTGIEMAWSEGRDLWWHHVVGSASPAHTPEPFDSEHPLFLLYTSGTTGKPKGIMHT
SGGYLTQCCYTMRTIFDVKPDSDVFWCTADIGWVTGHTYGVYGPLCNGVTEVLYEGTP
DTPDRHRHFQIIEKYGVTIYYTAPTLIRMFMKWGREIPDSHDLSSLRLLGSVGEPINP
EAWRWYRDVIGGGRTPLVDTWWQTETGSAMISPLPGIAAAKPGSAMTPLPGISAKIVD
DHGDPLPPHTEGAQHVTGYLVLDQPWPSMLRGIWGDPARYWHSYWSKFSDKGYYFAGD
GARIDPDGAIWVLGRIDDVMNVSGHRISTAEVESALVAHSGVAEAAVVGVTDETTTQA
ICAFVVLRANYAPHDRTAEELRTEVARVISPIARPRDVHVVPELPKTRSGKIMRRLLR
DVAENRELGDTSTLLDPTVFDAIRAAK"
gene complement(4109783..4110481)
/locus_tag="Rv3668c"
CDS complement(4109783..4110481)
/codon_start=1
/transl_table=11
/locus_tag="Rv3668c"
/product="Possible protease"
/note="Rv3668c, (MTV025.016c), len: 232 aa. Possible
protease (and more specifically a putative alkaline serine
protease, equivalent to Q9CB98|ML2295 hypothetical protein
from Mycobacterium leprae (234 aa), FASTA scores: opt:
1249, E(): 7.4e-66, (77.5% identity in 231 aa overlap).
Also similar at C-terminal end with many proteases e.g.
O86984 alkaline serine protease precursor from
Thermomonospora fusca (368 aa), FASTA scores: opt:
190,E(): 0.00056, (28.9% identity in 173 aa overlap);
Q55353|SAPII alkaline serine protease II from Streptomyces
sp (382 aa), FASTA scores: opt: 160, E(): 0.032, (27.15%
identity in 199 aa overlap); O54109|SC10A5.18 putative
secreted protease from Streptomyces coelicolor (411
aa),FASTA scores: opt: 155, E(): 0.066, (26.4% identity in
163 aa overlap); Q54392|SAL|SCI11.35C serine protease SAL
precursor (300 aa), FASTA scores: opt: 153, E():
0.068,(28.1% identity in 185 aa overlap);
P00778|PRLA_LYSEN|alpha-LP alpha-LYTIC protease precursor
(397 aa), FASTA scores: opt: 154, E(): 0.074, (26.75%
identity in 172 aa overlap); etc. Also similar with
Q50618|YI15_MYCTU|Rv1815|MT1863|MTCY1A11.28c hypothetical
22.8 KDA protein from Mycobacterium tuberculosis (221
aa),FASTA scores: opt: 134, E(): 0.69, (30.95% identity in
181 aa overlap). Conserved in M. tuberculosis, M. leprae,
M. bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3668c"
/db_xref="EnsemblGenomes-Tr:CCP46491"
/db_xref="GOA:I6YGW2"
/db_xref="InterPro:IPR009003"
/db_xref="UniProtKB/TrEMBL:I6YGW2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46491.1"
/translation="MQTAHRRFAAAFAAVLLAVVCLPANTAAADDKLPLGGGAGIVVN
GDTMCTLTTIGHDKNGDLIGFTSAHCGGPGAQIAAEGAENAGPVGIMVAGNDGLDYAV
IKFDPAKVTPVAVFNGFAINGIGPDPSFGQIACKQGRTTGNSCGVTWGPGESPGTLVM
QVCGGPGDSGAPVTVDNLLVGMIHGAFSDNLPSCITKYIPLHTPAVVMSINADLADIN
AKNRPGAGFVPVPA"
gene 4110827..4111345
/locus_tag="Rv3669"
CDS 4110827..4111345
/codon_start=1
/transl_table=11
/locus_tag="Rv3669"
/product="Probable conserved transmembrane protein"
/note="Rv3669, (MTV025.017), len: 172 aa. Probable
conserved transmembrane protein, equivalent to
Q9CB97|ML2296 putative membrane protein from Mycobacterium
leprae (181 aa), FASTA scores: opt: 863, E():
1.4e-47,(77.35% identity in 181 aa overlap). Also similar
to two putative integral membrane transport proteins from
Streptomyces coelicolor; Q9X930|SCH5.28 (162 aa) FASTA
scores: opt: 265, E(): 6.3e-10, (37.4% identity in 155 aa
overlap); and Q9X9W1|SCI7.29c (165 aa), FASTA scores: opt:
194, E(): 1.9e-05, (30.6% identity in 134 aa overlap).
Contains two hydrophobic stretches in centre."
/db_xref="EnsemblGenomes-Gn:Rv3669"
/db_xref="EnsemblGenomes-Tr:CCP46492"
/db_xref="GOA:O69637"
/db_xref="InterPro:IPR009937"
/db_xref="UniProtKB/TrEMBL:O69637"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46492.1"
/translation="MSKIDRKNGVPSTLTTIPLADPHAGPAEPSIGDLIKDATTQMST
LVRAEVELARAEITRDVKKGLTGSVFFISSLVVGFYSTFFFFFFVAELLDTWIWRWVA
FLLVFAIMVVVTAVLALLGFLKVRRIRGPRQTIASVKETRTALTPGHDKTPVTPKPVT
SDRATPVDPSGW"
gene 4111346..4112329
/gene="ephE"
/locus_tag="Rv3670"
CDS 4111346..4112329
/codon_start=1
/transl_table=11
/gene="ephE"
/locus_tag="Rv3670"
/product="Possible epoxide hydrolase EphE (epoxide
hydratase) (arene-oxide hydratase)"
/note="Rv3670, (MTV025.018), len: 327 aa. Possible
ephE,epoxide hydrolase (see citation below), equivalent to
Q9CB96|ML2297 putative hydrolase from Mycobacterium leprae
(324 aa), FASTA scores: opt: 1799, E(): 7.2e-105, (80.55%
identity in 324 aa overlap). Also similar to many
hydrolases (epoxide hydrolases) and hypothetical proteins
e.g. Q9X931|SCH5.29 putative hydrolase from Streptomyces
coelicolor (324 aa), FASTA scores: opt: 687, E():
1.4e-35,(40.65% identity in 327 aa overlap); Q9RRE3|DR2549
epoxide hydrolase-related protein from Deinococcus
radiodurans (278 aa), FASTA scores: opt: 321, E():
8.2e-13, (32.15% identity in 311 aa overlap);
Q9K3Q1|2SCG4.13 putative hydrolase from Streptomyces
coelicolor (292 aa), FASTA scores: opt: 295,E(): 3.5e-11,
(30.18% identity in 275 aa overlap); Q9S7P1 epoxide
hydrolase from Oryza sativa (Rice) (322 aa), FASTA scores:
opt: 289, E(): 9.1e-11, (28.7% identity in 338 aa
overlap); O23227|C7A10.830|AT4G36530 epoxide hydrolase
from Arabidopsis thaliana (Mouse-ear cress) (378 aa) FASTA
scores: opt: 287, E(): 1.4e-10, (26.1% identity in 272 aa
overlap); Q21147|K02F3.6 epoxide hydrolase from
Caenorhabditis elegans (386 aa), FASTA scores: opt:
283,E(): 2.5e-10, (33.35% identity in 156 aa overlap);
etc. Also similar to P95276|EPHB|Rv1938|MTCY09F9.26c from
Mycobacterium tuberculosis (356 aa), FASTA scores: opt:
296, E(): 3.6e-11, (29.7% identity in 340 aa overlap).
Contains PS00213 Lipocalin signature. Similar to
alpha/beta hydrolase fold."
/db_xref="EnsemblGenomes-Gn:Rv3670"
/db_xref="EnsemblGenomes-Tr:CCP46493"
/db_xref="GOA:I6YCQ4"
/db_xref="InterPro:IPR000073"
/db_xref="InterPro:IPR000639"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:I6YCQ4"
/inference="protein motif:PROSITE:PS00213"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46493.1"
/translation="MAAPDPSMTRIAGPWRHLDVHANGIRFHVVEAVPSGQPEGPDAA
TPPMQPALARPLVILLHGFGSFWWSWRHQLCGLTGARVVAVDLRGYGGSDKPPRGYDG
WTLAGDTAGLIRALGHPSATLVGHADGGLACWTTALLHSRLVRAIALISSPHPAALRR
STLTRRDQRHALLPTLLRYQLPIWPERLLTRNNAAEIERLVRARGCAKWLASEDFSQA
IDHLRQAIQIPAAAHCALEYQRWAVRSQLRSEGRRFIRAMTQQLGMPLLHLRGDADPY
VLADPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLEQVHQLS"
gene complement(4112322..4113515)
/locus_tag="Rv3671c"
CDS complement(4112322..4113515)
/codon_start=1
/transl_table=11
/locus_tag="Rv3671c"
/product="Membrane-associated serine protease"
/note="Rv3671c, (MTV025.019c), len: 397 aa. Serine
protease membrane protein, equivalent to Q9CB95|ML2298
putative membrane-associated serine protease from
Mycobacterium leprae (401 aa), FASTA scores: opt: 2061,
E(): 2.3e-108,(80.9% identity in 398 aa overlap). Also
similar to many serine proteases, but generally with
extended N-terminus,e.g. Q9X932|SCH5.30c putative serine
protease (fragment) from Streptomyces coelicolor (385 aa),
FASTA scores: opt: 835, E(): 1.2e-39, (39.9% identity in
386 aa overlap); Q9Z6T0|DEGP_CHLPN|HTRA|CPN0979|CP0877
probable serine protease do-like precursor from Chlamydia
pneumoniae (Chlamydophila pneumoniae) (488 aa), FASTA
scores: opt: 285, E(): 1e-08, (29.05% identity in 296 aa
overlap); P73354|HTRA|SLR1204 serine protease from
Synechocystis sp. strain PCC 6803 (452 aa), FASTA scores:
opt: 284, E(): 1.1e-08, (29.55% identity in 308 aa
overlap); Q9RWC4|DR0745 periplasmic serine protease,
HTRA/DEGQ/DEGS family from Deinococcus radiodurans (366
aa), FASTA scores: opt: 271,E(): 4.9e-08, (35.45% identity
in 206 aa overlap); etc. Also similar, but longer 114 aa
at the N-terminus, to Q9S2P8|SC5F7.13 putative peptidase
from Streptomyces coelicolor (282 aa), FASTA scores: opt:
594, E(): 3.1e-26,(38.95% identity in 285 aa overlap). And
similar, but longer 146 aa at the N-terminus, to
O07175|PEPA|Rv0125|MTCI418B.07 from Mycobacterium
tuberculosis (355 aa), FASTA scores: opt: 295, E():
2.2e-09, (29.55% identity in 254 aa overlap); and
Q9CCY9|ML2659 probable secreted serine protease from
Mycobacterium leprae FASTA scores: opt: 286, E():
6.9e-09,(30.6% identity in 255 aa overlap). Contains
PS00135 Serine proteases, trypsin family, serine active
site. Conserved in M. tuberculosis, M. leprae, M. bovis
and M. avium paratuberculosis; predicted to be essential
for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3671c"
/db_xref="EnsemblGenomes-Tr:CCP46494"
/db_xref="GOA:P9WHR9"
/db_xref="InterPro:IPR001940"
/db_xref="InterPro:IPR003825"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR033116"
/db_xref="PDB:3K6Y"
/db_xref="PDB:3K6Z"
/db_xref="PDB:3LT3"
/db_xref="UniProtKB/Swiss-Prot:P9WHR9"
/inference="protein motif:PROSITE:PS00135"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46494.1"
/translation="MTPSQWLDIAVLAVAFIAAISGWRAGALGSMLSFGGVLLGATAG
VLLAPHIVSQISAPRAKLFAALFLILALVVVGEVAGVVLGRAVRGAIRNRPIRLIDSV
IGVGVQLVVVLTAAWLLAMPLTQSKEQPELAAAVKGSRVLARVNEAAPTWLKTVPKRL
SALLNTSGLPAVLEPFSRTPVIPVASPDPALVNNPVVAATEPSVVKIRSLAPRCQKVL
EGTGFVISPDRVMTNAHVVAGSNNVTVYAGDKPFEATVVSYDPSVDVAILAVPHLPPP
PLVFAAEPAKTGADVVVLGYPGGGNFTATPARIREAIRLSGPDIYGDPEPVTRDVYTI
RADVEQGDSGGPLIDLNGQVLGVVFGAAIDDAETGFVLTAGEVAGQLAKIGATQPVGT
GACVS"
gene complement(4113521..4114342)
/locus_tag="Rv3672c"
CDS complement(4113521..4114342)
/codon_start=1
/transl_table=11
/locus_tag="Rv3672c"
/product="Conserved hypothetical protein"
/note="Rv3672c, (MTV025.020c), len: 273 aa. Conserved
hypothetical protein, equivalent to Q9CB94|ML2299
hypothetical protein from Mycobacterium leprae (266 aa)
FASTA scores: opt: 1358, E(): 5.2e-75, (76.4% identity in
267 aa overlap). Also similar to others (generally in
C-terminal end) e.g. Q9XA45|SCH17.02c hypothetical 26.5
KDA protein from Streptomyces coelicolor (247 aa) FASTA
scores: opt: 524, E(): 1.3e-24, (42.65% identity in 251 aa
overlap); Q9AB27|CC0407 mutt/NUDIX family protein from
Caulobacter crescentus (216 aa), FASTA scores: opt:
285,E(): 3.2e-10, (36.2% identity in 174 aa overlap);
BAB49788|MLL2727|Q98HS8 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (204 aa), FASTA
scores: opt: 278,E(): 8.1e-10, (31.45% identity in 151 aa
overlap); P43337|YEAB_ECOLI|B1813 hypothetical 21.4 KDA
protein from Escherichia coli strain K12 (192 aa) FASTA
scores: opt: 252, E(): 2.9e-08, (35.9% identity in 170 aa
overlap); etc. Contains PS01293 Uncharacterized protein
family UPF0036 signature, LLT."
/db_xref="EnsemblGenomes-Gn:Rv3672c"
/db_xref="EnsemblGenomes-Tr:CCP46495"
/db_xref="GOA:I6XHX8"
/db_xref="InterPro:IPR000059"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="UniProtKB/TrEMBL:I6XHX8"
/inference="protein motif:PROSITE:PS01293"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46495.1"
/translation="MSAGGTPLQAGATPTGSRGTVALRPDAGPSWLRPLVDNVGQIPD
AYRRRLPADVLAMVTAAGAVSAMTSSRRDHREAAVLVLFSGPEAGPGDGGVPDDADLL
LTVRASTLRHHAGQAAFPGGVVDPADDGPVATALREANEETGIDPSRLHPLATMERTF
IAPSRFHVVPVLAYSPDPGPVAVVNEAETAIVARVPVRAFINPANRLMVYRRPHTRRW
AGPAFLLNQMLVWGFTGQVISAVLDVAGWAQPWDTGDIRELDAAMVLIDDESDPR"
gene complement(4114474..4115157)
/locus_tag="Rv3673c"
CDS complement(4114474..4115157)
/codon_start=1
/transl_table=11
/locus_tag="Rv3673c"
/product="Possible membrane-anchored thioredoxin-like
protein (thiol-disulfide interchange related protein)"
/note="Rv3673c, (MTV025.021c), len: 227 aa. Possible
membrane protein, thioredoxin-like protein
(thiol-disulfide interchange protein), equivalent to
Q9CB93|ML2300 putative membrane protein from Mycobacterium
leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52,
(71.15% identity in 215 aa overlap). Some similarity with
thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA
protein from Bacillus subtilis (181 aa), FASTA scores:
opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa
overlap); Q9RXW6|DR0189 thiol:disulfide interchange
protein from Deinococcus radiodurans (185 aa) FASTA
scores: opt: 206, E(): 1.3e-05, (33.8% identity in 139 aa
overlap); Q9I505|PA0953 probable thioredoxin from
Pseudomonas aeruginosa (154 aa), FASTA scores: opt:
180,E(): 0.00044, (34.85% identity in 109 aa overlap);
Q9KCP7|BH1522 thioredoxin (thiol:disulfide interchange
protein) from Bacillus halodurans (177 aa), FASTA scores:
opt: 178, E(): 0.00064, (31.75% identity in 107 aa
overlap); P43221|TLPA_BRAJA thiol:disulfide interchange
protein (cytochrome C biogenesis protein) from
Bradyrhizobium japonicum (221 aa), FASTA scores: opt:
189,E(): 0.00017, (26.85% identity in 227 aa overlap);
etc. Also similar to O06392|Rv0526|MTCY25D10.05
hypothetical 23.2 KDA protein from Mycobacterium
tuberculosis (216 aa) FASTA scores: opt: 160, E(): 0.0093,
(27.45% identity in 142 aa overlap). Contains PS00194
Thioredoxin family active site. Possibly belongs to the
thioredoxin family."
/db_xref="EnsemblGenomes-Gn:Rv3673c"
/db_xref="EnsemblGenomes-Tr:CCP46496"
/db_xref="GOA:I6YGW6"
/db_xref="InterPro:IPR013740"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR017937"
/db_xref="InterPro:IPR036249"
/db_xref="UniProtKB/TrEMBL:I6YGW6"
/inference="protein motif:PROSITE:PS00194"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46496.1"
/translation="MPSLPTTPAETAMTTLTGKTRWTIAILAVVAALMAALVAQLHDY
SASSTISQRPAPREHRDGDTPEALAWSRQRANLPPCPAAGNGPGAAALRGVVVVCAGD
GSAVDVARALAGRRVVINLWAHWCAPCMTELPVMAEYQRRVGPAVLVVTVHQGQNEAA
ALSRLADLGVRLPTLQDDRRRVAAALRVANVMPATVVLRPDGSVAQTLPRAFGSADEI
VAAVGNDAG"
gene complement(4115157..4115894)
/gene="nth"
/locus_tag="Rv3674c"
CDS complement(4115157..4115894)
/codon_start=1
/transl_table=11
/gene="nth"
/locus_tag="Rv3674c"
/product="Probable endonuclease III Nth (DNA-(apurinic or
apyrimidinic site)lyase) (AP lyase) (AP endonuclease class
I) (endodeoxyribonuclease (apurinic or apyrimidinic))
(deoxyribonuclease (apurinic or apyrimidinic))"
/note="Rv3674c, (MT3775, MTV025.022c), len: 245 aa.
Probable nth, endonuclease III (see citation
below),equivalent to Q9CB92|nth|ML2301 putative
endonuclease III from Mycobacterium leprae (272 aa), FASTA
scores: opt: 1363, E(): 3.6e-81, (89.4% identity in 226 aa
overlap). Also similar to many e.g. Q9XA44|SCH17.03c from
Streptomyces coelicolor (250 aa), FASTA scores: opt:
937,E(): 2.2e-55, (61.65% identity in 219 aa overlap);
P46303|UVEN_MICLU from Micrococcus luteus (Micrococcus
lysodeikticus) (279 aa), FASTA scores: opt: 899, E():
8.1e-53, (58.45% identity in 248 aa overlap);
P73715|END3_SYNY3|nth|SLR1822 from Synechocystis sp.
strain PCC 6803 (219 aa), FASTA scores: opt: 684, E():
1.7e-38,(52.2% identity in 203 aa overlap);
P39788|END3_BACSU|nth|JOOB from Bacillus subtilis (219
aa),FASTA scores: opt: 552, E(): 1.2e-29, (43.3% identity
in 194 aa overlap); etc. Equivalent to AAK48142 from
Mycobacterium tuberculosis strain CDC1551 (262 aa) but
shorter 17 aa. Contains PS00764 Endonuclease III
iron-sulfur binding region signature, and PS01155
Endonuclease III family signature. Belongs to the nth/MUTY
family. Cofactor: binds a 4FE-4S cluster which is not
important for the catalytic activity, but which is
probably involved in the proper positioning of the enzyme
along the DNA strand (by similarity). N-terminus extended
since first submission (previously 226 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3674c"
/db_xref="EnsemblGenomes-Tr:CCP46497"
/db_xref="GOA:P9WQ11"
/db_xref="InterPro:IPR000445"
/db_xref="InterPro:IPR003265"
/db_xref="InterPro:IPR003651"
/db_xref="InterPro:IPR004035"
/db_xref="InterPro:IPR004036"
/db_xref="InterPro:IPR005759"
/db_xref="InterPro:IPR011257"
/db_xref="InterPro:IPR023170"
/db_xref="UniProtKB/Swiss-Prot:P9WQ11"
/inference="protein motif:PROSITE:PS00764"
/inference="protein motif:PROSITE:PS01155"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46497.1"
/translation="MPGRWSAETRLALVRRARRMNRALAQAFPHVYCELDFTTPLELA
VATILSAQSTDKRVNLTTPALFARYRTARDYAQADRTELESLIRPTGFYRNKAASLIG
LGQALVERFGGEVPATMDKLVTLPGVGRKTANVILGNAFGIPGITVDTHFGRLVRRWR
WTTAEDPVKVEQAVGELIERKEWTLLSHRVIFHGRRVCHARRPACGVCVLAKDCPSFG
LGPTEPLLAAPLVQGPETDHLLALAGL"
gene 4116002..4116379
/locus_tag="Rv3675"
CDS 4116002..4116379
/codon_start=1
/transl_table=11
/locus_tag="Rv3675"
/product="Possible membrane protein"
/note="Rv3675, (MTV025.023), len: 125 aa. Possible
membrane protein, with some similarity to Q9YCZ2|APE1120
hypothetical 11.7 KDA protein from Aeropyrum pernix (103
aa), FASTA scores: opt: 100, E(): 9, (40.0% identity in 55
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3675"
/db_xref="EnsemblGenomes-Tr:CCP46498"
/db_xref="UniProtKB/TrEMBL:I6YCQ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46498.1"
/translation="MFTLLVSWLLVACVPGLLMLATLGLGRLERFLARDTVTATDVAE
FLEQAEAVDVHTLARNGMPEALDYLHRRQARRITDSPPLGSGAGPRYAGPLFVTDLDS
PVEPPRHGQPNPQFRTARHANHV"
gene 4116478..4117152
/gene="crp"
/locus_tag="Rv3676"
CDS 4116478..4117152
/codon_start=1
/transl_table=11
/gene="crp"
/locus_tag="Rv3676"
/product="Transcriptional regulatory protein Crp
(Crp/Fnr-family)"
/note="Rv3676, (MTV025.024), len: 224 aa.
Crp,transcriptional regulator belonging to crp/fnr
family,identical to Q9CB91|ML2302 putative Crp/Fnr-family
transcriptional regulator from Mycobacterium leprae (224
aa), FASTA scores: opt: 1408, E(): 8.8e-81, (95.95%
identity in 224 aa overlap). Also highly similar to
transcriptional regulators AAK58838 from Corynebacterium
glutamicum (Brevibacterium flavum) (227 aa), FASTA scores:
opt: 1178, E(): 1.9e-66, (79.9% identity in 224 aa
overlap); and Q9XA42|SCH17.05 from Streptomyces coelicolor
(224 aa), FASTA scores: opt: 869, E(): 3.4e-47, (54.45%
identity in 224 aa overlap); and similar to others e.g.
Q9RRX0|DR2362 from Deinococcus radiodurans (231 aa) FASTA
scores: opt: 344, E(): 1.8e-14, (30.8% identity in 211 aa
overlap); P29281|CRP_HAEIN from Haemophilus influenzae
(224 aa), FASTA scores: opt: 330, E(): 1.3e-13, (32.25%
identity in 189 aa overlap);
P03020|CRP_ECOLI|cap|CSM|B3357 from Escherichia coli
strain K12 and Shigella flexneri (210 aa),FASTA scores:
opt: 323, E(): 3.5e-13, (32.25% identity in 189 aa
overlap); etc. Contains helix-turn-helix motif at aa
175-196 (Score 1990, +5.96 SD). Belongs to the Crp/Fnr
family of transcriptional regulators. Binds cAMP."
/db_xref="EnsemblGenomes-Gn:Rv3676"
/db_xref="EnsemblGenomes-Tr:CCP46499"
/db_xref="GOA:P9WMH3"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR012318"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:3D0S"
/db_xref="PDB:3H3U"
/db_xref="PDB:3I54"
/db_xref="PDB:3I59"
/db_xref="PDB:3MZH"
/db_xref="PDB:4A2U"
/db_xref="UniProtKB/Swiss-Prot:P9WMH3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46499.1"
/translation="MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPG
DRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAV
SMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQR
FGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSER
LARRAR"
gene complement(4117258..4118052)
/locus_tag="Rv3677c"
CDS complement(4117258..4118052)
/codon_start=1
/transl_table=11
/locus_tag="Rv3677c"
/product="Possible hydrolase"
/note="Rv3677c, (MTV025.025c), len: 264 aa. Possible
hydrolase, equivalent to Q9CB90|ML2303 putative hydrolase
from Mycobacterium leprae (262 aa) FASTA scores: opt:
1400,E(): 8.5e-81, (82.05% identity in 262 aa overlap).
Also similar to other hydrolases and hypothetical proteins
e.g. Q9XA41|SCH17.06c putative hydrolase from Streptomyces
coelicolor (256 aa) FASTA scores: opt: 609, E():
3.9e-31,(54.65% identity in 247 aa overlap); Q9A9Q1|CC0923
metallo-beta-lactamase family protein from Caulobacter
crescentus (297 aa), FASTA scores: opt: 306, E():
4.7e-12,(35.45% identity in 268 aa overlap); Q9Y392 CGI-83
protein from Homo sapiens (Human) (288 aa), FASTA scores:
opt: 281,E(): 1.7e-10, (33.2% identity in 259 aa overlap);
Q9F7R6 predicted metallobeta lactamase fold protein from
uncultured proteobacterium EBAC31A08 (265 aa), FASTA
scores: opt: 257, E(): 5.1e-09, (32.55% identity in 252 aa
overlap); Q9PBI4|XF2160 hydroxyacylglutathione hydrolase
from Xylella fastidiosa (258 aa), FASTA scores: opt:
232,E(): 1.9e-07, (30.3% identity in 165 aa overlap); etc.
Recombinant protein has beta lactamase activity (See
Nampoothiri et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3677c"
/db_xref="EnsemblGenomes-Tr:CCP46500"
/db_xref="GOA:I6XHY3"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036866"
/db_xref="InterPro:IPR041516"
/db_xref="UniProtKB/TrEMBL:I6XHY3"
/protein_id="CCP46500.1"
/translation="MSKTAESLTHPAYGQLRAVTDTASVLLADNPGLLTLDGTNTWVL
RGPLSDELVVVDPGPDDDEHLARVAALGRIALVLISHRHGDHTSGIDKLVALTGAPVR
AADPQFLRRDGETLTDGEVIDVAGLTITVLATPGHTADSLSFVLDDAVLTADTVLGCG
TTVIDKEDGSLADYLESLHRLRGLGRRTVLPGHGPDLLDLEAIASGYLLHRHERLEQI
RAALRDLGDDATVREVVEHVYLDVDEKLWNAAEWSVQAQLDYLRTR"
gene complement(4118059..4118514)
/locus_tag="Rv3678c"
CDS complement(4118059..4118514)
/codon_start=1
/transl_table=11
/locus_tag="Rv3678c"
/product="Conserved protein"
/note="Rv3678c, (MTV025.026c), len: 151 aa. Conserved
protein, equivalent, but shorter 23 aa, to Q9CB89|ML2304
hypothetical protein from Mycobacterium leprae (174
aa),FASTA scores: opt: 746, E(): 2.1e-40, (78.15% identity
in 151 aa overlap). Also highly similar to many
hypothetical proteins or transcription regulators e.g.
Q9XA38|SCH17.09c from Streptomyces coelicolor (155 aa),
FASTA scores: opt: 637, E(): 1.5e-33, (69.1% identity in
152 aa overlap); BAB48205|MLR0658 from Rhizobium loti
(Mesorhizobium loti) (154 aa), FASTA scores: opt: 500,
E(): 6.8e-25, (55.35% identity in 150 aa overlap);
BAB50615|MLR3802 transcription regulator from Rhizobium
loti (Mesorhizobium loti) (153 aa), FASTA scores: opt:
425,E(): 3.8e-20, (44.35% identity in 151 aa overlap);
Q9U0W7|L7276.02 from Leishmania major (163 aa) FASTA
scores: opt: 404, E(): 8.5e-19, (47.7% identity in 151 aa
overlap); Q9UZA3|PAB0825 putative translation initiation
inhibitor from Pyrococcus abyssi (127 aa), FASTA scores:
opt: 108, E(): 3.7, (30.75% identity in 130 aa overlap);
etc. Contains PS00044 Bacterial regulatory proteins, lysR
family signature."
/db_xref="EnsemblGenomes-Gn:Rv3678c"
/db_xref="EnsemblGenomes-Tr:CCP46501"
/db_xref="InterPro:IPR013813"
/db_xref="InterPro:IPR035959"
/db_xref="UniProtKB/TrEMBL:I6YGW9"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46501.1"
/translation="MSAKARLGQLGVTLPQVAAPLAAYVPAVRTGNLVYTAGQLPLEA
GKLVRTGKLGADVNPEEGKTLARICALNALAAVDSLVDLDAVTRVVKVVGFVASAPGF
HGQPSVINGASDLLAEVFGDSGAHARSAVGVSELPLDAPVEVELIVEVG"
gene complement(4118530..4118691)
/locus_tag="Rv3678A"
CDS complement(4118530..4118691)
/codon_start=1
/transl_table=11
/locus_tag="Rv3678A"
/product="Conserved hypothetical protein"
/note="Rv3678A, len: 53 aa. Conserved hypothetical
protein,similar to SCH17.10|AL079353_10 conserved
hypothetical protein from Streptomyces coelicolor (53 aa),
FASTA scores: opt: 259, E(): 1.5e-13, (78.0% identity in
50 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3678A"
/db_xref="EnsemblGenomes-Tr:CCP46502"
/db_xref="InterPro:IPR025234"
/db_xref="UniProtKB/TrEMBL:I6X824"
/protein_id="CCP46502.1"
/translation="MTQPTAWEYATVPLLTHATKQILDQWGADGWELVAVLPGPTGEQ
HVAYLKRPK"
gene 4118776..4119798
/locus_tag="Rv3679"
CDS 4118776..4119798
/codon_start=1
/transl_table=11
/locus_tag="Rv3679"
/product="Probable anion transporter ATPase"
/note="Rv3679, (MTV025.027), len: 340 aa. Probable anion
transporting ATPase, equivalent to Q9CB88|ML2305 probable
anion transporter protein from Mycobacterium leprae (341
aa), FASTA scores: opt: 1810, E(): 2.1e-98, (84.15%
identity in 341 aa overlap). Also highly similar to
Q9XA36|SCH17.11 putative ion-transporting ATPase from
Streptomyces coelicolor (325 aa), FASTA scores: opt:
989,E(): 1.4e-50, (52.15% identity in 328 aa overlap); and
similar to many anion transporting ATPases (principally
arsenite transporters) e.g. O50593|ARSA_ACIMU arsenical
pump-driving ATPase (arsenite-translocating ATPase) from
Acidiphilium multivorum (583 aa), FASTA scores: opt:
225,E(): 8.1e-06, (25.1% identity in 319 aa overlap);
AAG43231|ARSA arsenite activated ATPase from Salmonella
typhimurium plasmid R46 FASTA scores: opt: 211, E():
5.3e-05, (26.95% identity in 267 aa overlap);
P52145|ARA2_ECOLI|ARSA arsenical pump-driving ATPase from
Escherichia coli plasmid IncN R46 (583 aa), FASTA scores:
opt: 211, E(): 5.3e-05, (26.95% identity in 267 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Some similarity to the ARSA ATPase family."
/db_xref="EnsemblGenomes-Gn:Rv3679"
/db_xref="EnsemblGenomes-Tr:CCP46503"
/db_xref="GOA:P9WKX5"
/db_xref="InterPro:IPR016300"
/db_xref="InterPro:IPR025723"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:6BS3"
/db_xref="PDB:6BS4"
/db_xref="PDB:6BS5"
/db_xref="UniProtKB/Swiss-Prot:P9WKX5"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46503.1"
/translation="MVATTSSGGSSVGWPSRLSGVRLHLVTGKGGTGKSTIAAALALT
LAAGGRKVLLVEVEGRQGIAQLFDVPPLPYQELKIATAERGGQVNALAIDIEAAFLEY
LDMFYNLGIAGRAMRRIGAVEFATTIAPGLRDVLLTGKIKETVVRLDKNKLPVYDAIV
VDAPPTGRIARFLDVTKAVSDLAKGGPVHAQSEGVVKLLHSNQTAIHLVTLLEALPVQ
ETLEAIEELAQMELPIGSVIVNRNIPAHLEPQDLAKAAEGEVDADSVRAGLLTAGVKL
PDADFAGLLTETIQHATRITARAEIAQQLDALQVPRLELPTVSDGVDLGSLYELSESL
AQQGVR"
gene 4119795..4120955
/locus_tag="Rv3680"
CDS 4119795..4120955
/codon_start=1
/transl_table=11
/locus_tag="Rv3680"
/product="Probable anion transporter ATPase"
/note="Rv3680, (MTV025.028), len: 386 aa. Probable anion
transporting ATPase, equivalent to Q9CB87|ML2306 probable
anion transporter protein from Mycobacterium leprae (381
aa), FASTA scores: opt: 2131, E(): 6.5e-120, (88.1%
identity in 370 aa overlap). Also highly similar, but
shorter 29 aa, to Q9XA35|SCH17.12 putative
ion-transporting ATPase from Streptomyces coelicolor (481
aa), FASTA scores: opt: 1190, E(): 1.1e-63, (51.25%
identity in 441 aa overlap); and similar to many anion
transporting ATPases e.g. Q9UZA6|PAB1555 anion
transporting ATPase from Pyrococcus abyssi (330 aa) FASTA
scores: opt: 242, E(): 3e-07, (24.6% identity in 297 aa
overlap); Q9P7F8|SPAC1142.06 putative
arsenite-translocating from Schizosaccharomyces pombe
(Fission yeast) (329 aa), FASTA scores: opt: 239, E():
4.5e-07, (27.9% identity in 197 aa overlap);
Q9HS79|ARSA1|VNG0365G arsenical pump-driving ATPase from
Halobacterium sp. strain NRC-1 (347 aa), FASTA scores:
opt: 238, E(): 5.4e-07, (29.35% identity in 358 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3680"
/db_xref="EnsemblGenomes-Tr:CCP46504"
/db_xref="GOA:I6Y498"
/db_xref="InterPro:IPR016300"
/db_xref="InterPro:IPR025723"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:6BS5"
/db_xref="UniProtKB/TrEMBL:I6Y498"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46504.1"
/translation="MSVTPKTLDMGAILADTSNRVVVCCGAGGVGKTTTAAALALRAA
EYGRTVVVLTIDPAKRLAQALGINDLGNTPQRVPLAPEVPGELHAMMLDMRRTFDEMV
MQYSGPERAQSILDNQFYQTVATSLAGTQEYMAMEKLGQLLSQDRWDLIVVDTPPSRN
ALDFLDAPKRLGSFMDSRLWRLLLAPGRGIGRLITGVMGLAMKALSTVLGSQMLADAA
AFVQSLDATFGGFREKADRTYALLKRRGTQFVVVSAAEPDALREASFFVDRLSQESMP
LAGLVFNRTHPMLCALPIERAIDAAETLDAETTDSDATSLAAAVLRIHAERGQTAKRE
IRLLSRFTGANPTVPVVGVPSLPFDVSDLEALRALADQLTTVGNDAGRAAGR"
gene complement(4121198..4121554)
/gene="whiB4"
/gene_synonym="whmA"
/locus_tag="Rv3681c"
CDS complement(4121198..4121554)
/codon_start=1
/transl_table=11
/gene="whiB4"
/gene_synonym="whmA"
/locus_tag="Rv3681c"
/product="Probable transcriptional regulatory protein
WhiB-like WhiB4"
/note="Rv3681c, (MTV025.029c), len: 118 aa. Probable whiB4
(alternate gene name: whmA), WhiB-like regulatory protein
(see Hutter & Dick 1999), similar to WhiB paralogue of
Streptomyces coelicolor, wblE gene product (85 aa).
Equivalent to ML2307 hypothetical protein from
Mycobacterium leprae (116 aa). Also highly similar to
Q9S2B9|SCH17.13c putative regulatory protein from
Streptomyces coelicolor (112 aa), FASTA scores: opt:
392,E(): 1e-20, (67.95% identity in 78 aa overlap);
Q9X951|WBLA hypothetical 14.3 KDA protein from
Streptomyces coelicolor (129 aa), FASTA scores: opt: 392,
E(): 1.1e-20, (67.95% identity in 78 aa overlap);
Q9ACZ0|SCP1.161c putative regulatory protein from
Streptomyces coelicolor (268 aa),FASTA scores: opt: 273,
E(): 4.4e-12, (50.0% identity in 78 aa overlap);
Q06387|WHIB-STV from Streptomyces griseocarneus (87 aa)
FASTA scores: opt: 231, E(): 1.5e-09,(43.85% identity in
73 aa overlap); etc. Also similar to several putative
regulator proteins from Mycobacterium tuberculosis e.g.
MTCY7D11_7; MTCY78_13; MTCY10H4_23; MTCY1A6_6; and
U00016_29 from Mycobacterium leprae. N-terminus shortened
since first submission."
/db_xref="EnsemblGenomes-Gn:Rv3681c"
/db_xref="EnsemblGenomes-Tr:CCP46505"
/db_xref="GOA:P9WF39"
/db_xref="InterPro:IPR003482"
/db_xref="InterPro:IPR034768"
/db_xref="UniProtKB/Swiss-Prot:P9WF39"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46505.1"
/translation="MSGTRPAARRTNLTAAQNVVRSVDAEERIAWVSKALCRTTDPDE
LFVRGAAQRKAAVICRHCPVMQECAADALDNKVEFGVWGGMTERQRRALLKQHPEVVS
WSDYLEKRKRRTGTAG"
gene 4121916..4124348
/gene="ponA2"
/locus_tag="Rv3682"
CDS 4121916..4124348
/codon_start=1
/transl_table=11
/gene="ponA2"
/locus_tag="Rv3682"
/product="Probable bifunctional membrane-associated
penicillin-binding protein 1A/1B PonA2 (murein polymerase)
[includes: penicillin-insensitive transglycosylase
(peptidoglycan TGASE) + penicillin-sensitive
transpeptidase (DD-transpeptidase)]"
/note="Rv3682, (MTV025.030), len: 810 aa. Probable
ponA2,penicillin-binding protein (class A), bienzymatic
membrane-associated protein with transglycosylase and
transpeptidase activities. Almost identical to
Q9CB85|PON1|ML2308 penicillin binding protein (class A)
from Mycobacterium leprae (803 aa) FASTA scores: opt:
4743,E(): 3.3e-217, (87.7% identity in 806 aa overlap); or
P72351|PON1|PBP1 high-molecular-mass class a penicillin
binding protein from Mycobacterium leprae Cosmid B577 (821
aa), FASTA scores: opt: 4547, E(): 6.3e-208, (88.05%
identity in 769 aa overlap) (see Basu et al., 1996). Also
equivalent to a predicted homologous protein from
Mycobacterium smegmatis. Also similar to others e.g.
Q9XA34|SCH17.14 from Streptomyces coelicolor (428 aa;
fragment), FASTA scores: opt: 727, E(): 2.3e-27, (36.55%
identity in 413 aa overlap); Q9F9V7|PONA from
Mycobacterium smegmatis (715 aa), FASTA scores: opt: 446,
E(): 6.6e-14,(27.65% identity in 771 aa overlap) (see
Billman-Jacobe et al., 1999); Q9CCY4|PONA|ML2688 from
Mycobacterium leprae (708 aa), FASTA scores: opt: 413,
E(): 2.4e-12, (26.8% identity in 660 aa overlap);
Q9X6W0|PONB|MRCB|PA4700 from Pseudomonas aeruginosa (774
aa), FASTA scores: opt: 398,E(): 1.3e-11, (27.2% identity
in 666 aa overlap); P45345|PBPB_HAEIN|MRCB|PONB|HI1725
(781 aa), FASTA scores: opt: 380, E(): 9.4e-11, (28.6%
identity in 601 aa overlap); etc. Also similar to
P71707|PONA1|Rv0050|MTCY21.13 probable bifunctional
penicillin-binding protein 1A/1B (PBP1) from Mycobacterium
tuberculosis (678 aa) FASTA scores: opt: 372,E(): 2e-10,
(28.35% identity in 769 aa overlap). Seems to belong to
the transglycosylase family in the N-terminal section, and
to the transpeptidase family in the C-terminal section."
/db_xref="EnsemblGenomes-Gn:Rv3682"
/db_xref="EnsemblGenomes-Tr:CCP46506"
/db_xref="GOA:I6YGX2"
/db_xref="InterPro:IPR001264"
/db_xref="InterPro:IPR001460"
/db_xref="InterPro:IPR005543"
/db_xref="InterPro:IPR012338"
/db_xref="InterPro:IPR023346"
/db_xref="InterPro:IPR036950"
/db_xref="PDB:2MGV"
/db_xref="UniProtKB/TrEMBL:I6YGX2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46506.1"
/translation="MPERLPAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRAS
EVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTMKLAIVSIED
KRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKNYQLLVTAQTDAEKRAAV
ETTPARKLREIRMALTLDKTFTKSEILTRYLNLVSFGNNSFGVQDAAQTYFGINASDL
NWQQAALLAGMVQSTSTLNPYTNPDGALARRNVVLDTMIENLPGEAEALRAAKAEPLG
VLPQPNELPRGCIAAGDRAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPV
KAAIDKYASPNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLV
GDGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSGGAKGCPKETWCVVNAGN
YRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRSYANPGTARDYNPDSNE
SLADFVKRQNLGSFTLGPIELNALELSNVAATLASGGVWCPPNPIDQLIDRNGNEVAV
TTETCDQVVPAGLANTLANAMSKDAVGSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAG
FVGFTNRYAAANYIYDDSSSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNF
GEVQLPPTDPRYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGE
VVGTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPPVGSQVVEIPGLPPITI
PLLAPPPPAPPP"
gene 4124417..4125376
/locus_tag="Rv3683"
CDS 4124417..4125376
/codon_start=1
/transl_table=11
/locus_tag="Rv3683"
/product="Conserved protein"
/note="Rv3683, (MTV025.031), len: 319 aa. Conserved
protein, equivalent to Q9CB84|ML2309 hypothetical protein
from Mycobacterium leprae (330 aa) FASTA scores: opt:
1791,E(): 9e-107, (85.45% identity in 296 aa overlap).
Also similar to Q9X935|SCH66.03 conserved hypothetical
protein from Streptomyces coelicolor (309 aa) FASTA
scores: opt: 610, E(): 1.4e-31, (51.45% identity in 307 aa
overlap); and Q9RRY7|YN45_DEIRA|DR2345 hypothetical
protein from Deinococcus radiodurans (305 aa) FASTA
scores: opt: 243,E(): 3.2e-08, (31.1% identity in 315 aa
overlap) and some similarity to other hypothetical
bacterial proteins e.g. Q9CF81|YQED from Lactococcus
lactis (subsp. lactis) (Streptococcus lactis) (278 aa)
FASTA scores: opt: 200,E(): 1.6e-05, (26.85% identity in
287 aa overlap). Predicted to be an outer membrane protein
(See Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3683"
/db_xref="EnsemblGenomes-Tr:CCP46507"
/db_xref="GOA:I6X827"
/db_xref="InterPro:IPR024654"
/db_xref="InterPro:IPR029052"
/db_xref="UniProtKB/TrEMBL:I6X827"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46507.1"
/translation="MAAVLPTLIRTGAVALGSAIAGIGYAALVERNAFVLREVTMPVL
TPGSTPLRVLHISDLHMLPNQHRKQAWLRELASWEPDLVVNTGDNLAHPKAVPAVVQT
LSDLLSRPGVFVFGSNDYFGPRLKNPMNYLTSPDHRVRGAALPWQDLRAAFTERGWLD
LTHTRREFEVAGLHIAAAGVDDPHIDRDRYDTIAGPASPAANLRLGLTHSPEPRVLDR
FAADGYQLVLAGHTHGGQLCLPLYGALVTNCGLDRSRAKGASHWGANMRLHVSAGIGT
SPFAPVRFCCRPEATLLTLIATPMGGRDSSSNLGRSQPTVSVR"
gene 4125439..4126479
/locus_tag="Rv3684"
CDS 4125439..4126479
/codon_start=1
/transl_table=11
/locus_tag="Rv3684"
/product="Probable lyase"
/note="Rv3684, (MTV025.032), len: 346 aa. Probable lyase
,and more specifically a cysteine synthase, highly similar
to many lyases e.g. Q9K3N2|SCG20A.08c putative lyase from
Streptomyces coelicolor (374 aa), FASTA scores: opt:
1469,E(): 3.7e-85, (63.35% identity in 341 aa overlap)
(shorter 31 aa at N-terminus); Q9KT44|VC1061 cysteine
synthase/ cystathionine beta-synthase family protein from
Vibrio cholerae (355 aa), FASTA scores: opt: 1366, E():
1.1e-78,(63.25% identity in 321 aa overlap); Q9I4R3|PA1061
hypothetical protein from Pseudomonas aeruginosa (365
aa),FASTA scores: opt: 1311, E(): 3.2e-75, (59.8% identity
in 341 aa overlap); Q9PH18|XF0128 cysteine synthase from
Xylella fastidiosa (390 aa), FASTA scores: opt: 1288, E():
9.5e-74, (58.55% identity in 333 aa overlap) (shorter 34
aa at N-terminus); P55708|Y4XP_RHISN putative cysteine
synthase from Rhizobium sp. strain NGR234 plasmid sym
pNGR234a (336 aa), FASTA scores: opt: 376, E():
2.1e-16,(29.2% identity in 315 aa overlap); etc.
Equivalent to AAK48153 from Mycobacterium tuberculosis
strain CDC1551 (368 aa) but shorter 22 aa."
/db_xref="EnsemblGenomes-Gn:Rv3684"
/db_xref="EnsemblGenomes-Tr:CCP46508"
/db_xref="GOA:O69652"
/db_xref="InterPro:IPR001926"
/db_xref="InterPro:IPR036052"
/db_xref="UniProtKB/TrEMBL:O69652"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46508.1"
/translation="MIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSL
KHRLARSLFLYALCNGWINENTTVVEASSGSTAVSEAYFAALLGLPFIAVMPAATSAS
KIALIESQGGRCHFVQNSSQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAES
IYVQMREEKHPTPEWIVVGAGTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSE
GRYDIVMPTSSRIEGIGRPRVEPSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGP
STGTNLWGAFGLLAEMVKQGRSGSVVTLLADSGDRYADTYFSDEWVSAQGLDPAGPAA
ALVEFERSCRWT"
gene 4126541..4126614
/gene="proY"
tRNA 4126541..4126614
/gene="proY"
/product="tRNA-Pro"
/anticodon=(pos:4126575..4126577,aa:Pro,seq:cgg)
/note="codon recognized: CCG; proY, tRNA-Pro, anticodon
cgg, length = 74"
gene complement(4127295..4128725)
/gene="cyp137"
/locus_tag="Rv3685c"
CDS complement(4127295..4128725)
/codon_start=1
/transl_table=11
/gene="cyp137"
/locus_tag="Rv3685c"
/product="Probable cytochrome P450 137 Cyp137"
/note="Rv3685c, (MTV025.033c), len: 476 aa. Probable
cyp137, cytochrome P-450, similar to many e.g.
Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila
melanogaster (Fruit fly) (495 aa), FASTA scores: opt:
376,E(): 1.2e-15, (28.35% identity in 413 aa overlap);
Q59163|CYP110A2 from Anabaena variabilis (459 aa) FASTA
scores: opt: 320, E(): 3.1e-12, (31.4% identity in 411 aa
overlap); O23051|C883_ARATH from Arabidopsis thaliana
(Mouse-ear cress) (490 aa), FASTA scores: opt: 313, E():
8.8e-12, (28.25% identity in 425 aa overlap); etc. Also
similar to many from Mycobacterium tuberculosis e.g.
O53765|C13B_MYCTU|CYP135B1|Rv0568|MT0594|MTV039.06 (472
aa), FASTA scores: opt: 920, E(): 4.6e-49, (36.25%
identity in 447 aa overlap);
P96813|C138_MYCTU|CYP138|Rv0136|MT0144|MTCI5.10 (441 aa)
FASTA scores: opt: 886, E(): 5.3e-47, (35.5% identity in
445 aa overlap); etc. Belongs to the cytochrome P450
family."
/db_xref="EnsemblGenomes-Gn:Rv3685c"
/db_xref="EnsemblGenomes-Tr:CCP46509"
/db_xref="GOA:P9WPM5"
/db_xref="InterPro:IPR001128"
/db_xref="InterPro:IPR002401"
/db_xref="InterPro:IPR017972"
/db_xref="InterPro:IPR036396"
/db_xref="UniProtKB/Swiss-Prot:P9WPM5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46509.1"
/translation="MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGL
PAPRGFRAAFAAAYAVAYLAGGERRMLRLIRRYGPIMTMPILSLGDVAIVSDSALAKE
VFTAPTDVLLGGEGVGPAAAIYGSGSMFVQEEPEHLRRRKLLTPPLHGAALDRYVPII
ENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLG
VSEQLTVRYALRRLGALRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLV
SARGESGEQLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGG
GEAFTTAVINETLRVRPPAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVYE
HPHEFRPERFLGTRPQTYAWVPFGGGVKRCLGANFSMRELITVLHVLLREGEFTAVDD
EPERIVRRSIMLVPRRGTRVRFRPAR"
gene complement(4128751..4129083)
/locus_tag="Rv3686c"
CDS complement(4128751..4129083)
/codon_start=1
/transl_table=11
/locus_tag="Rv3686c"
/product="Conserved hypothetical protein"
/note="Rv3686c, (MTV025.034c), len: 110 aa. Hypothetical
protein, similar to P96893|Rv3288c|MTCY71.28c hypothetical
15.2 KDA protein from Mycobacterium tuberculosis (and
Mycobacterium bovis) (137 aa) FASTA scores: opt: 106, E():
5.6, (29.1% identity in 79 aa overlap); and a few
hypothetical proteins e.g. Q9GUV6|L2259.2 from Leishmania
major (360 aa) FASTA scores: opt: 118, E(): 2.1, (28.7%
identity in 101 aa overlap). Equivalent to AAK48155 from
Mycobacterium tuberculosis strain CDC1551 (166 aa) but
shorter 56 aa."
/db_xref="EnsemblGenomes-Gn:Rv3686c"
/db_xref="EnsemblGenomes-Tr:CCP46510"
/db_xref="UniProtKB/TrEMBL:O69654"
/protein_id="CCP46510.1"
/translation="MVYTGSDAGDHASAPQPSGSGSVPASVNVPGLVVAAVWAVGLVA
GLVALTIGHLAVAAAALVVAVMAPWCRVAYIAHGQHRVCGETLRGTPAGETASFPTGW
RGLRFSTR"
gene complement(4129323..4129691)
/gene="rsfB"
/locus_tag="Rv3687c"
CDS complement(4129323..4129691)
/codon_start=1
/transl_table=11
/gene="rsfB"
/locus_tag="Rv3687c"
/product="Anti-anti-sigma factor RsfB (anti-sigma factor
antagonist) (regulator of sigma F B)"
/note="Rv3687c, (MTV025.035c), len: 122 aa.
RsfB,anti-anti-sigma factor (see citation below), showing
some similarity to sporulation proteins and sigma-factor
genes e.g. Q9WVX8|RSBV_STRCO|bldg|SCH5.12c anti-sigma B
factor antagonist from Streptomyces coelicolor (113 aa)
FASTA scores: opt: 163, E(): 0.0007, (31.15% identity in
106 aa overlap); Q9F3A2|SC5F1.27c putative anti-sigma
factor antagonist from Streptomyces coelicolor (114 aa)
FASTA scores: opt: 159, E(): 0.0013, (29.8% identity in
104 aa overlap); P73609|SLR1859 hypothetical 12.0 KDA
protein from Synechocystis sp. strain PCC 6803 (108 aa)
FASTA scores: opt: 152, E(): 0.0034, (32.2% identity in 90
aa overlap); L47358|BACSPOI_1 spoIIA a from Paenibacillus
polymyxa (117 aa), FASTA scores: opt: 107, E(): 0.23,
(24.8% identity in 113 aa overlap); SQSIGB_4 rsbU, rsbV,
rsbW & sigB genes from Steptomyces aureus (108 aa) (28.3%
identity in 60 aa overlap); etc. Also similar to
hypothetical proteins from Mycobacterium tuberculosis e.g.
MTCY180_14 and MTCY441 _8."
/db_xref="EnsemblGenomes-Gn:Rv3687c"
/db_xref="EnsemblGenomes-Tr:CCP46511"
/db_xref="GOA:P9WGE1"
/db_xref="InterPro:IPR002645"
/db_xref="InterPro:IPR003658"
/db_xref="InterPro:IPR036513"
/db_xref="UniProtKB/Swiss-Prot:P9WGE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46511.1"
/translation="MSAPDSITVTVADHNGVAVLSIGGEIDLITAAALEEAIGEVVAD
NPTALVIDLSAVEFLGSVGLKILAATSEKIGQSVKFGVVARGSVTRRPIHLMGLDKTF
RLFSTLHDALTGVRGGRIDR"
gene complement(4129893..4130357)
/locus_tag="Rv3688c"
CDS complement(4129893..4130357)
/codon_start=1
/transl_table=11
/locus_tag="Rv3688c"
/product="Conserved protein"
/note="Rv3688c, (MTV025.036c), len: 154 aa. Conserved
protein, similar to other bacterial hypothetical proteins
e.g. Q9X934|SCH66.02c from Streptomyces coelicolor (154
aa), FASTA scores: opt: 425, E(): 3.4e-19, (46.1% identity
in 154 aa overlap); Q9WZF4|TM0690 from Thermotoga maritima
(149 aa), FASTA scores: opt: 326, E(): 3.4e-13, (40.4%
identity in 151 aa overlap); Q9PHU3|CJ0573 from
Campylobacter jejuni (147 aa), FASTA scores: opt:290 ,
E(): 5.1e-11, (36.4% identity in 151 aa overlap); etc.
Also some similarity to upstream
O69654|Rv3686c|MTV025.034c conserved hypothetical protein
from Mycobacterium tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv3688c"
/db_xref="EnsemblGenomes-Tr:CCP46512"
/db_xref="GOA:I6X831"
/db_xref="InterPro:IPR003789"
/db_xref="InterPro:IPR019004"
/db_xref="InterPro:IPR023168"
/db_xref="InterPro:IPR042184"
/db_xref="UniProtKB/TrEMBL:I6X831"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46512.1"
/translation="MAELKSQLRSDLTQAMKTQDKLRTATIRMLLAAIQTEEVSGKQA
RELSDDEVIKVLARESRKRGEAAEIYTQNGRGELAATEHAEARIIDEYLPTPLTEGEL
ADVADTAIAEVAEELGHRPSMKQMGLVMKAATVIAAGKADGARLSAAVKERL"
gene 4130357..4131712
/locus_tag="Rv3689"
CDS 4130357..4131712
/codon_start=1
/transl_table=11
/locus_tag="Rv3689"
/product="Probable conserved transmembrane protein"
/note="Rv3689, (MTV025.037), len: 451 aa. Probable
conserved transmembrane protein, with Proline rich
N-terminus, similar to Q9KYW6|SCE33.17 putative integral
membrane protein from Streptomyces coelicolor (462 aa)
FASTA scores: opt: 730, E(): 2.7e-21, (38.1% identity in
412 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3689"
/db_xref="EnsemblGenomes-Tr:CCP46513"
/db_xref="GOA:I6YCR8"
/db_xref="UniProtKB/TrEMBL:I6YCR8"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46513.1"
/translation="MHKRYAPQRPKPDTETYIEKCTDRRQDGGHDERRQLLRPVSMLP
PGYPVEPPPVAPGYAPAGYPPYPATPPGYGPPGYGAPPSYGPPPGYGPPLGYPAAPPG
CGPPPGYGPPLGYGPPVAPGAVKPGIIPLRPLTLSDIFNGAVGYIRANPKATLGLTAM
VVVTLQIISLVALFGPMTAFGDIVTGEPDELTGAVVGGWSASFGASLLVSWLAGVLLS
GMLTVIVGRAVFGSPITVGEAWAKVRGRLLALFGLALLEAAGVVAVLGLAVVILSGVA
AAANEAAAALLGFPLLLVVGVSLAYLYVVLLFAPVLIVLERLPIVEAITRSFALVRHG
FWRVLGIRLLTVLVVGVVGNAIAAPFMIVGEIVTAVTASDGSVTMRLVGATLSAIGVT
IGQIVTAPFSAGVVVLLYTDRRIRAEAFDLVLQTGLEAGPAGGPAPVESTDNLWLTRP
F"
gene 4131739..4132392
/locus_tag="Rv3690"
CDS 4131739..4132392
/codon_start=1
/transl_table=11
/locus_tag="Rv3690"
/product="Probable conserved membrane protein"
/note="Rv3690, (MTV025.038), len: 217 aa. Probable
conserved membrane protein, similar to Q9KYW5|SCE33.18
putative integral membrane protein from Streptomyces
coelicolor (231 aa), FASTA scores: opt: 419, E():
1.5e-19,(36.0% identity in 211 aa overlap). Equivalent to
AAK48159 from Mycobacterium tuberculosis strain CDC1551
(233 aa) but shorter 16 aa."
/db_xref="EnsemblGenomes-Gn:Rv3690"
/db_xref="EnsemblGenomes-Tr:CCP46514"
/db_xref="GOA:O69658"
/db_xref="InterPro:IPR025403"
/db_xref="UniProtKB/TrEMBL:O69658"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46514.1"
/translation="MPSIDIDREAAHQAAQRELDKPIYPKDSLTKELTDWIDEQLYRI
LEKGSSIPGGWFTITVLLILLMIAVTAAVQIARRTMRTNRGGDYQLFDAGQLTAAQHR
STAESYAAEGNWAAAIRHRLQAVARELEETGMLNPAAGRTANELASDAGEVLPHLAGE
LTQAATAFNDVTYGERPGTQGAYQMIADLDDHLRSRSPAVVSAVQHPAVFDSWAQVR"
gene 4132518..4133519
/locus_tag="Rv3691"
CDS 4132518..4133519
/codon_start=1
/transl_table=11
/locus_tag="Rv3691"
/product="Conserved protein"
/note="Rv3691, (MTV025.039), len: 333 aa. Conserved
protein, similar to Q9KYW4|SCE33.19 putative secreted
protein from Streptomyces coelicolor (387 aa) FASTA
scores: opt: 481, E(): 6e-23, (36.6% identity in 358 aa
overlap). Equivalent to AAK48160 from Mycobacterium
tuberculosis strain CDC1551 (381 aa) but shorter 48 aa."
/db_xref="EnsemblGenomes-Gn:Rv3691"
/db_xref="EnsemblGenomes-Tr:CCP46515"
/db_xref="GOA:O69659"
/db_xref="InterPro:IPR025646"
/db_xref="UniProtKB/Swiss-Prot:O69659"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46515.1"
/translation="MAPASTSSTGGHALATLLGNHGVEVVVADSIADVEAAARPDSLL
LVAQTQYLVDNALLDRLAKAPGDLLLVAPTSRTRTALTPQLRIAAASPFNSQPNCTLR
EANRAGSVQWGPSDTYQATGDLVLTSCYGGALVRFRAEGRTITVVGSSNFMTNGGLLP
AGNAALAMNLAGNRPRLVWYAPDHIEGEMSSPSSLSDLIPENVHWTIWQLWLVVLLVA
LWKGRRIGPLVAEELPVVIRASETVEGRGRLYRSRRARDRAADALRTATLQRLRPRLG
VGAGAPAPAVVTTIAQRSKADPPFVAYHLFGPAPATDNDLLQLARALDDIERQVTHS"
gene 4133516..4134592
/gene="moxR2"
/locus_tag="Rv3692"
CDS 4133516..4134592
/codon_start=1
/transl_table=11
/gene="moxR2"
/locus_tag="Rv3692"
/product="Probable methanol dehydrogenase transcriptional
regulatory protein MoxR2"
/note="Rv3692, (MTV025.040), len: 358 aa. Probable
moxR2,methanol dehydrogenase regulatory protein, highly
similar (generally longer at N-terminus) to
Q9KYW3|SCE33.20 putative regulatory protein from
Streptomyces coelicolor (329 aa), FASTA scores: opt: 1523,
E(): 4.2e-74, (70.9% identity in 330 aa overlap);
Q9Z538|SC9B2.21c putative regulatory protein from
Streptomyces coelicolor (332 aa) FASTA scores: opt: 1008,
E(): 1.1e-46, (50.8% identity in 313 aa overlap);
Q9UZ67|MOXR-3|PAB0848 methanol dehydrogenase regulatory
protein from Pyrococcus abyssi (314 aa), FASTA scores:
opt: 989, E(): 1.1e-45, (50.65% identity in 302 aa
overlap); Q9AAN1|CC0566 MOXR protein from Caulobacter
crescentus (323 aa), FASTA scores: opt: 988, E(): 1.3e-45,
(52.3% identity in 306 aa overlap); etc. Also similar to
O53170|MTV007.26|MOXR|Rv1479 from Mycobacterium
tuberculosis (377 aa); and O07392|AF002133_6|MOXR from
Mycobacterium avium (309 aa). Also high similarity with
several hypothetical bacterial proteins."
/db_xref="EnsemblGenomes-Gn:Rv3692"
/db_xref="EnsemblGenomes-Tr:CCP46516"
/db_xref="GOA:I6YGX9"
/db_xref="InterPro:IPR011703"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041628"
/db_xref="UniProtKB/TrEMBL:I6YGX9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46516.1"
/translation="MTQSASNPQAPPTQTPGAELPGYPPQAGGAPTAAPSGPHPHRAE
AESARDALLALRAEVAKAVVGQDGVISGLVIALLCRGHVLLEGVPGVAKTLIVRAMSA
ALQLEFKRVQFTPDLMPGDVTGSLVYDARTAEFVFRPGPVFTNLLLADEINRTPPKTQ
AALLEAMEERQVSVEGEPKPLPNPFIVAATQNPIEYEGTYQLPEAQLDRFLLKLNVTL
PARDSEIAILDRHAHGFDPRDLSAINPVAGPAELAAGREAVRHVLVANEVLGYIVDIV
GATRSSPALQLGVSPRGATALLGTARSWAWLSGRDYVTPDDVKAMARPTLRHRVMLRP
EAELEGATPDGVLDGILASVPVPR"
repeat_region 4134601..4134725
/note="125 bp Mycobacterial Interspersed Repetitive
Unit,Class III."
gene 4134726..4136048
/locus_tag="Rv3693"
CDS 4134726..4136048
/codon_start=1
/transl_table=11
/locus_tag="Rv3693"
/product="Possible conserved membrane protein"
/note="Rv3693, (MTV025.041), len: 440 aa (alternative
start at 41910). Possible conserved membrane protein,
similar to Q9KYW2|SCE33.21 putative lipoprotein from
Streptomyces coelicolor (436 aa), FASTA scores: opt: 875,
E(): 3.3e-46,(56.25% identity in 448 aa overlap);
Q9AAN0|CC0567 hypothetical protein from Caulobacter
crescentus (437 aa),FASTA scores: opt: 355, E(): 2.3e-14,
(30.9% identity in 450 aa overlap); P73233|SLR2013
hypothetical 48.5 KDA protein from Synechocystis sp.
strain PCC 6803 (435 aa),FASTA scores: opt: 340, E():
1.9e-13, (29.7% identity in 438 aa overlap); etc.
Equivalent to AAK48162 from Mycobacterium tuberculosis
strain CDC1551 (475 aa) but shorter 35 aa. Also similar to
other hypothetical proteins from Mycobacterium
tuberculosis; MTV014_7; MTV007_27; and MTCY71_36 M.
Predicted to be an outer membrane protein (See Song et
al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3693"
/db_xref="EnsemblGenomes-Tr:CCP46517"
/db_xref="GOA:O69661"
/db_xref="InterPro:IPR002881"
/db_xref="UniProtKB/TrEMBL:O69661"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46517.1"
/translation="MILTGRTGLLALICVLPIALSPWPARAFVMLLVALAVAVTVDTL
LAASTRKLRFTRSPYTSARLGQPVDASLLLCNGGRRRFRGQVRDAWPPSARAQPHTHD
VDVAAGQRQQVHTALRPVRRGDQRAAMVTARSIGPLGLAGRQSSQSVPGLVRVLPPFL
SRKHLPSRLAKLREIDGLLPTLIRGQGTEFDSLREYVVGDDVRSIDWRASARRADVMV
RTWRPERDRRVVIVLDTGRMAAGRVGVDPTAADPAGWPRLDWSMDAALLLAALASRAG
DHVDFLAHDRISRAGVFGASRSELLAQLVDAMAPLRPALIESDWHAMIATILRRTRRR
SLVVLLTDLNATALDEGLLPVLPQLSARHHVLVAAVADPRVDQLAAGRSDAAAVYDAA
AAERARNDRRAIASQLRRGGVDVIDAPPAEIAPGLADRYLAMKATGRL"
gene complement(4136122..4137114)
/locus_tag="Rv3694c"
CDS complement(4136122..4137114)
/codon_start=1
/transl_table=11
/locus_tag="Rv3694c"
/product="Possible conserved transmembrane protein"
/note="Rv3694c, (MTV025.042c), len: 330 aa. Possible
conserved transmembrane protein, highly similar to
Q9KZM4|SCE34.01c putative integral membrane protein from
Streptomyces coelicolor (335 aa), FASTA scores: opt:
1113,E(): 2.5e-60, (51.5% identity in 334 aa overlap); and
similar to Q9KEW6|BH0733 hypothetical protein from
Bacillus halodurans (355 aa), FASTA scores: opt: 381, E():
6.1e-16,(24.15% identity in 331 aa overlap); Q9AAM9|CC0568
hypothetical protein from Caulobacter crescentus (332
aa),FASTA scores: opt: 352, E(): 3.3e-14, (30.3% identity
in 310 aa overlap); P74166|SLR1478 hypothetical 35.4 KDA
protein from Synechocystis sp. strain PCC 6803 (317
aa),FASTA scores: opt: 330, E(): 6.8e-13, (25.65% identity
in 308 aa overlap); etc. C-terminal end shows similarity
to O29631|AF0624|AE001061_10 conserved hypothetical
protein (putative nifU protein) from Archaeoglobus
fulgidus (185 aa), FASTA scores: opt: 154, E(): 0.021,
(29.0% identity in 131 aa overlap). Equivalent to AAK48163
from Mycobacterium tuberculosis strain CDC1551 (395 aa)
but shorter 65 aa. Also some similarity to MTCY428_20
hypothetical 43.7 KDA protein from Mycobacterium
tuberculosis."
/db_xref="EnsemblGenomes-Gn:Rv3694c"
/db_xref="EnsemblGenomes-Tr:CCP46518"
/db_xref="GOA:O69662"
/db_xref="InterPro:IPR002798"
/db_xref="UniProtKB/TrEMBL:O69662"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46518.1"
/translation="MDVDAFLLTNRGTWDRLDHLIKKRHSLSGAEIDELVELYQRVST
HLSMLRSASSDQLMTGRLSSLVARARSAVTGAHAPLTRTFIRFWTVSFPVVAYRTWRW
WLATAVAFFAVVVLIGFWVAGSHEVQSAIGTPTEIDELVSHDVQSYYSEHPAASFALQ
VWVNNSWVATTCIAMSVVLGLPIPLVLFDNAANVGLIAGLMFQAGKGDFLLGLLLPHG
LLELTAVFLAAAIGMRLGWSVISAGNRPRGQVLAEQGRGVVSVAVGLVGVFLVAGLIE
AVVTPSPLPTFVRIAVGIIAEAVFLSYIGYFGRRAAQAGETGDMEDAPDVVPTG"
gene 4137206..4138138
/locus_tag="Rv3695"
CDS 4137206..4138138
/codon_start=1
/transl_table=11
/locus_tag="Rv3695"
/product="Possible conserved membrane protein"
/note="Rv3695, (MTV025.043), len: 310 aa. Possible
conserved membrane protein, equivalent, but longer 88
aa,to Q9CB83|ML2312 possible membrane protein from
Mycobacterium leprae (196 aa), FASTA scores: opt: 898,
E(): 5.2e-36, (71.05% identity in 190 aa overlap). Also
highly similar to Q9KZM3|SCE34.02 putative integral
membrane protein from Streptomyces coelicolor (318 aa),
FASTA scores: opt: 740,E(): 2.4e-28, (43.25% identity in
319 aa overlap); and similar to P72718|SLR0254
hypothetical 30.4 KDA protein from Synechocystis sp.
strain PCC 6803 (266 aa), FASTA scores: opt: 287, E():
6.1e-07, (29.6% identity in 260 aa overlap); Q9HW83|PA4318
hypothetical protein from Pseudomonas aeruginosa (265 aa),
FASTA scores: opt: 250,E(): 3.5e-05, (32.0% identity in
203 aa overlap); Q9KEW5|BH0734 hypothetical protein from
Bacillus halodurans (266 aa), FASTA scores: opt: 168, E():
0.0047, (25.95% identity in 231 aa overlap); etc.
C-terminal end shows some similarity to proline-rich
proteins e.g. Q62106 proline-rich salivary protein
(fragment) from Mus musculus (Mouse) (188 aa) (36.1%
identity in 97 aa overlap). Equivalent to AAK48164 from
Mycobacterium tuberculosis strain CDC1551 (269 aa) but
longer 41 aa."
/db_xref="EnsemblGenomes-Gn:Rv3695"
/db_xref="EnsemblGenomes-Tr:CCP46519"
/db_xref="GOA:O69663"
/db_xref="InterPro:IPR010432"
/db_xref="UniProtKB/TrEMBL:O69663"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46519.1"
/translation="MSEVVTGDAVVLDVQIAQLPVRAVSAVIDITIIFIGYILGLMLW
ATALTQFDEALTTAFLIIFTVLALVGYPLVWETATRGRSVGKIVMGLRVVSDDGGPER
FRQALFRALASVVEIWMLLGSPAVICSMLSPKAKRVGDVFAGTVVVSERGPRLGPPPV
MPPSLAWWASSLQLSGLTAGQAEVARQFLVRAPQLDPALREQMAYRIAGDVVARIAPP
PPPGVPPQLVLAAVLAERHRRELLRLRPTLPPAGQAPWAQMAPHRGWPPGLSGATPWS
PQQPVIPWPEPDPPPQAAPWPQQAPDGPGFSPPG"
gene complement(4138202..4139755)
/gene="glpK"
/locus_tag="Rv3696c"
CDS complement(4138202..4139755)
/codon_start=1
/transl_table=11
/gene="glpK"
/locus_tag="Rv3696c"
/product="Probable glycerol kinase GlpK (ATP:glycerol
3-phosphotransferase) (glycerokinase) (GK)"
/note="Rv3696c, (MTV025.044c), len: 517 aa. Probable
glpK,glycerol kinase, equivalent to
Q9CB81|GLPK_MYCLE|ML2314 glycerol kinase from
Mycobacterium leprae (508 aa), FASTA scores: opt: 3120,
E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also
highly similar to others e.g. Q9RJM2|GLPK from
Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606,
E(): 1.1e-156, (75.35% identity in 503 aa overlap);
Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA
scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503
aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga
maritima (496 aa), FASTA scores: opt: 1838, E():
2.7e-108,(54.8% identity in 498 aa overlap);
P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12
(501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3%
identity in 499 aa overlap); etc. Contains PS00933 FGGY
family of carbohydrate kinases signature 1, PS00070
Aldehyde dehydrogenases cysteine active site, PS00445 FGGY
family of carbohydrate kinases signature 2. Belongs to the
fucokinase / gluconokinase / glycerokinase / xylulokinase
family."
/db_xref="EnsemblGenomes-Gn:Rv3696c"
/db_xref="EnsemblGenomes-Tr:CCP46520"
/db_xref="GOA:P9WPK1"
/db_xref="InterPro:IPR000577"
/db_xref="InterPro:IPR005999"
/db_xref="InterPro:IPR018483"
/db_xref="InterPro:IPR018484"
/db_xref="InterPro:IPR018485"
/db_xref="UniProtKB/Swiss-Prot:P9WPK1"
/inference="protein motif:PROSITE:PS00445"
/inference="protein motif:PROSITE:PS00070"
/inference="protein motif:PROSITE:PS00933"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46520.1"
/translation="MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQL
EHEQILPRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVWNR
HTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYFSGGKLQWILENVD
GVRAAAENGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNASRTMLMDLETLDWDDELL
SLFSIPRAMLPEIASSAPSEPYGVTLATGPVGGEVPITGVLGDQHAAMVGQVCLAPGE
AKNTYGTGNFLLLNTGETIVRSNNGLLTTVCYQFGNAKPVYALEGSIAVTGSAVQWLR
DQLGIISGAAQSEALARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAH
LARATLEAICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQADVLGVDVVRP
VVAETTALGVAYAAGLAVGFWAAPSDLRANWREDKRWTPTWDDDERAAGYAGWRKAVQ
RTLDWVDVS"
gene complement(4139805..4140242)
/gene="vapC48"
/locus_tag="Rv3697c"
CDS complement(4139805..4140242)
/codon_start=1
/transl_table=11
/gene="vapC48"
/locus_tag="Rv3697c"
/product="Possible toxin VapC48. Contains PIN domain."
/note="Rv3697c, (MTV025.045c), len: 145 aa. Possible
vapC48, toxin, part of toxin-antitoxin (TA) operon with
Rv3697A, contains PIN domain, see Arcus et al. 2005.
Similar to many others in Mycobacterium tuberculosis e.g.
Q10800|YS72_MYCTU|Rv2872|MT2939|MTCY274.03 (147 aa) FASTA
scores: opt: 223, E(): 7.3e-08, (32.6% identity in 141 aa
overlap); O53501|Rv2103c|MTV020.03 (144 aa), FASTA scores:
opt: 215, E(): 2.4e-07, (31.4% identity in 137 aa
overlap); O53812|Rv0749|MTV041.23 (142 aa), FASTA scores:
opt: 192,E(): 7.6e-06, (31.25% identity in 144 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3697c"
/db_xref="EnsemblGenomes-Tr:CCP46521"
/db_xref="GOA:P9WF47"
/db_xref="InterPro:IPR002716"
/db_xref="InterPro:IPR006226"
/db_xref="InterPro:IPR022907"
/db_xref="InterPro:IPR029060"
/db_xref="UniProtKB/Swiss-Prot:P9WF47"
/protein_id="CCP46521.1"
/translation="MSETFDVDVLVHATHRASPFHDKAKTLVERFLAGPGLVYLLWPV
ALGYLRVVTHPTLLGAPLAPEVAVENIEQFTSRPHVRQVGEANGFWPVYRRVADPVKP
RGNLVPDAHLVALMRHHGIATIWSHDRDFRKFEGIRIRDPFSG"
gene complement(4140239..4140463)
/gene="vapB48"
/locus_tag="Rv3697A"
CDS complement(4140239..4140463)
/codon_start=1
/transl_table=11
/gene="vapB48"
/locus_tag="Rv3697A"
/product="Possible antitoxin VapB48"
/note="Rv3697A, len: 74 aa. Possible vapB48,
antitoxin,part of toxin-antitoxin (TA) operon with
Rv3697c, see Arcus et al. 2005. Similar to others in M.
tuberculosis e.g. Rv3321c, Rv0748"
/db_xref="EnsemblGenomes-Gn:Rv3697A"
/db_xref="EnsemblGenomes-Tr:CCP46522"
/db_xref="UniProtKB/Swiss-Prot:P9WJ15"
/protein_id="CCP46522.1"
/translation="MRTTIDLDDDILRALKRRQREERKTLGQLASELLAQALAAEPPP
NVDIRWSTADLRPRVDLDDKDAVWAILDRG"
gene 4140493..4142022
/locus_tag="Rv3698"
CDS 4140493..4142022
/codon_start=1
/transl_table=11
/locus_tag="Rv3698"
/product="Conserved protein"
/note="Rv3698, (MTV025.046), len: 509 aa. Conserved
protein, highly similar to Q9AK89|SC10A9.15c conserved
hypothetical protein from Streptomyces coelicolor (505
aa),FASTA scores: opt: 1720, E(): 9e-103, (53.65% identity
in 494 aa overlap). N-terminal end highly similar to
CAC42136|SCBAC25F8.01 conserved hypothetical protein
(fragment) from Streptomyces coelicolor (291 aa), FASTA
scores: opt: 1078, E(): 8.7e-62, (52.6% identity in 291 aa
overlap); and C-terminus highly similar to
CAC44687|SCBAC17A6.42c (235 aa), FASTA scores: opt:
911,E(): 3.8e-51, (57.25% identity in 234 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3698"
/db_xref="EnsemblGenomes-Tr:CCP46523"
/db_xref="GOA:I6YCS6"
/db_xref="InterPro:IPR014746"
/db_xref="InterPro:IPR016602"
/db_xref="UniProtKB/TrEMBL:I6YCS6"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46523.1"
/translation="MRTISPFLRCRHETCCISNVGEEVTRTTYSREHQREYRRKVRLC
LDVFETMLAQTRFEADRPLTGMEIECNLVDADYQPAMSNRYVLDAIADPAYQTELGAY
NIEFNVPPRPLPGRTCLELEDEVRASLNDAETKASCSGAHIVMIGILPTLMPEHLTDG
WMSASARYAALNESIFKARGEDIPINIAGPEPLSCHAGSIAPESACTSVQLHLQLAPA
DFPANWNAAQVLAGPQLALGANSPYFFGHQLWSETRIELFTQSTDARPEELKSRGVRP
RVWFGERWITSVLDLFQENIRYFPTLLPEVSDEDPLAELSAGRIPHLSELRLHNGTVY
RWNRPVYDVVDGRPHLRLENRVLPAGPTVVDMLANHAFYYGALRGLSEADPPLWTQMN
FAAAQANFLAAARYGMDAQLDWPGLGEVTTRELVLGTLLPMAHEGLRRWGVDAEVRDR
FLGVIGGRAQTGRNGARWQVATVAALQDGGLTRPAALAEMLRRYCEHMHSNEPVHTWD
T"
gene 4142044..4142745
/locus_tag="Rv3699"
CDS 4142044..4142745
/codon_start=1
/transl_table=11
/locus_tag="Rv3699"
/product="Conserved protein"
/note="Rv3699, (MTV025.047), len: 233 aa. Conserved
protein, showing similarity with hypothetical proteins
e.g. Q9P3V6|SPAC1348.04 (alias Q9P3E7|SPAC750.03c or
Q9P7U5|SPAC977.03) from Schizosaccharomyces pombe (Fission
yeast) (145 aa), FASTA scores: opt: 188, E():
7.5e-05,(31.65% identity in 120 aa overlap); and
Q9KB70|BH2058 from Bacillus halodurans (241 aa) FASTA
scores: opt: 185, E(): 0.00018, (27.8% identity in 162 aa
overlap); Q9XA90|SCF43A.25c putative methyltransferase
from Streptomyces coelicolor (215 aa), FASTA scores: opt:
166,E(): 0.0025, (29.95% identity in 147 aa overlap); etc.
Also highly similar to O06426|Rv0560c|MTCY25D10.39c
hypothetical 25.9 KDA protein from Mycobacterium
tuberculosis (241 aa),FASTA scores: opt: 690, E():
6.5e-36, (53.4% identity in 234 aa overlap); and similar
to other hypothetical proteins from Mycobacterium
tuberculosis e.g. P71805|Rv1377c|MTCY02B12.11c (212 aa)
FASTA scores: opt: 378, E(): 1.5e-16, (35.4% identity in
192 aa overlap); P71972|Rv2675c|MTCY441.44c (250 aa) FASTA
scores: opt: 297,E(): 2e-11, (31.1% identity in 193 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3699"
/db_xref="EnsemblGenomes-Tr:CCP46524"
/db_xref="GOA:O69667"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR041698"
/db_xref="UniProtKB/TrEMBL:O69667"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46524.1"
/translation="MTDEVMDWDSAYREQGAFEGPPPWNIGEPQPELATLIAAGKVRS
DVLDAGCGYAELSLALAADGYTVVGIDLTPTAVAAATKAAEERGLTTASFVQADITEF
AAYPAGSAGRFSTVIDSTLFHSLPVDSRDRYLSSVHRAAAPGASYYVLVFAKGAFPAE
LEVKPNEVDEDELRAAVSKYWKIDEIRPAFIHVNPVTIPPQLAGAPVEFPPYDHDEKG
RVKFPAYLLTAHKAG"
gene complement(4142748..4143920)
/locus_tag="Rv3700c"
CDS complement(4142748..4143920)
/codon_start=1
/transl_table=11
/locus_tag="Rv3700c"
/product="Conserved hypothetical protein"
/note="Rv3700c, (MTV025.048c), len: 390 aa. Conserved
hypothetical protein; could be a transferase or a lyase.
Indeed, similar to various enzymes e.g. Q53824|CAC
capreomycin acetyltransferase from Streptomyces capreolus
(359 aa), FASTA scores: opt: 338, E(): 1.1e-12, (33.35%
identity in 363 aa overlap); Q9HXX3|CSD_PSEAE|PA3667
probable cysteine desulfurase from Pseudomonas aeruginosa
(401 aa) FASTA scores: opt: 260, E(): 4.8e-08, (30.2%
identity in 404 aa overlap); Q9X815|SC6G10.30 putative
aminotransferase from Streptomyces coelicolor (460
aa),FASTA scores: opt: 243, E(): 5.4e-07, (29.15% identity
in 374 aa overlap); Q9A761|CC1865 aminotransferase class V
from Caulobacter crescentus (379 aa), FASTA scores: opt:
234, E(): 1.6e-06, (27.95% identity in 383 aa overlap);
O74351|NFS1_SCHPO|SPBC21D10.11c probable cysteine
desulfurase from Schizosaccharomyces pombe (Fission yeast)
(498 aa), FASTA scores: opt: 232, E(): 2.5e-06, (29.1%
identity in 285 aa overlap); Q9RME8|NIFS NIFS protein
(cysteine desulfurase, tRNA splicing protein) from
Zymomonas mobilis (370 aa), FASTA scores: opt: 230, E():
2.6e-06, (32.85% identity in 201 aa overlap); etc.
Contains PS00626 Regulator of chromosome condensation
(RCC1) signature 2."
/db_xref="EnsemblGenomes-Gn:Rv3700c"
/db_xref="EnsemblGenomes-Tr:CCP46525"
/db_xref="GOA:O69668"
/db_xref="InterPro:IPR000192"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR027563"
/db_xref="UniProtKB/Swiss-Prot:O69668"
/inference="protein motif:PROSITE:PS00626"
/protein_id="CCP46525.1"
/translation="MRRSGANSPAGDSLADRWRAARPPVAGLHLDSAACSRQSFAALD
AAAQHARHEAEVGGYVAAEAAAAVLDAGRAAVAALSGLPDAEVVFTTGSLHALDLLLG
SWPGENRTLACLPGEYGPNLAVMAAHGFDVRPLPTLQDGRVALDDAAFMLADDPPDLV
HLTVVASHRGVAQPLAMVAQLCTELKLPLVVDAAQGLGHVDCAVGADVTYASSRKWIA
GPRGVGVLAVRPELMERLRARLPAPDWMPPLTVAQQLGFGEANVAARVGFSVALGEHL
ACGPQAIRARLAELGDIARTVLADVSGWRVVEAVDEPSAITTLAPIDGADPAAVRAWL
LSQRRIVTTYAGVERAPLELPAPVLRISPHVDNTADDLDAFAEALVAATAATSGER"
gene complement(4143951..4144916)
/locus_tag="Rv3701c"
CDS complement(4143951..4144916)
/codon_start=1
/transl_table=11
/locus_tag="Rv3701c"
/product="Conserved hypothetical protein"
/note="Rv3701c, (MTV025.049c), len: 321 aa. Conserved
hypothetical protein, highly similar to other hypothetical
proteins e.g. Q9RCZ8|SCM1.46 from Streptomyces coelicolor
(251 aa), FASTA scores: opt: 897, E(): 1.1e-50, (59.9%
identity in 242 aa overlap); P73759|SLR0865 from
Synechocystis sp. strain PCC 6803 (337 aa), FASTA scores:
opt: 779, E(): 5.7e-43, (40.35% identity in 327 aa
overlap); Q9GWA1|LM12.997 from Leishmania major (383 aa)
FASTA scores: opt: 616, E(): 2.1e-32, (39.05% identity in
297 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3701c"
/db_xref="EnsemblGenomes-Tr:CCP46526"
/db_xref="GOA:P9WN47"
/db_xref="InterPro:IPR017804"
/db_xref="InterPro:IPR019257"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR032888"
/db_xref="InterPro:IPR035094"
/db_xref="UniProtKB/Swiss-Prot:P9WN47"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46526.1"
/translation="MRVSVANHLGEDAGHLALRRDVYSGLQKTPKSLPPKWFYDTVGS
ELFDQITRLPEYYPTRAEAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDALRH
RGSLRRFVPFDVDASVLSATATAIQREYSGVEINAVCGDFEEHLTEIPRGGRRLFVFL
GSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRAYDDPGGVTAQFNR
NVLAVINRELEADFDVDAFQHVARWNSAEERIEMWLRADGRQRVRVGALDLTVDFDAG
EEMLTEVSCKFRPQAVGAELAAAGLHRIRWWTDEAGDFGLSLAAK"
gene complement(4144913..4145614)
/locus_tag="Rv3702c"
CDS complement(4144913..4145614)
/codon_start=1
/transl_table=11
/locus_tag="Rv3702c"
/product="Conserved hypothetical protein"
/note="Rv3702c, (MTV025.050c), len: 233 aa. Conserved
hypothetical protein, highly similar to other hypothetical
proteins Q9RCZ9|SCM1.45 from Streptomyces coelicolor (271
aa), FASTA scores: opt: 383, E(): 2.3e-17, (44.85%
identity in 252 aa overlap); and P54004|Y199_SYNY3|SLR0199
from Synechocystis sp. strain PCC 6803 (304 aa), FASTA
scores: opt: 292, E(): 1.7e-11, (30.05% identity in 263 aa
overlap); and similar to others e.g. Q9KMU4|VCA0225 from
Vibrio cholerae (254 aa), FASTA scores: opt: 260, E():
1.6e-09, (29.8% identity in 245 aa overlap). Equivalent to
AAK48172 from Mycobacterium tuberculosis strain CDC1551
(194 aa) but longer 39 aa."
/db_xref="EnsemblGenomes-Gn:Rv3702c"
/db_xref="EnsemblGenomes-Tr:CCP46527"
/db_xref="GOA:O69670"
/db_xref="InterPro:IPR017808"
/db_xref="InterPro:IPR017932"
/db_xref="InterPro:IPR029055"
/db_xref="InterPro:IPR032889"
/db_xref="UniProtKB/Swiss-Prot:O69670"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46527.1"
/translation="MCRHLGWLGAQVAVSSLVLDPPQGLRVQSYAPRRQKHGLMNADG
WGVGFFDGAIPRRWRSPAPLWGDTSFHSVAPALRSHCILAAVRSATVGMPIEVSATPP
FTDGHWLLAHNGVVDRAVLPAGPAAESVCDSAILAATIFAHGLDALGDTIVKVGAADP
NARLNILAANGSRLIATTWGDTLSILRRADGVVLASEPYDDDSGWGDVPDRHLVEVTQ
KGVTLTALDRAKGPR"
gene complement(4145614..4146891)
/locus_tag="Rv3703c"
CDS complement(4145614..4146891)
/codon_start=1
/transl_table=11
/locus_tag="Rv3703c"
/product="Conserved hypothetical protein"
/note="Rv3703c, (MTV025.051c), len: 425 aa. Conserved
hypothetical protein, similar to other hypothetical
proteins e.g. Q9RD00|SCM1.44 from Streptomyces coelicolor
(446 aa), FASTA scores: opt: 1480, E(): 1.4e-85, (53.9%
identity in 421 aa overlap); P72841|SLR1303 from
Synechocystis sp. strain PCC 6803 (410 aa), FASTA scores:
opt: 533, E(): 4.5e-26, (36.6% identity in 429 aa
overlap); Q9KYH7|SCC61A.16 from Streptomyces coelicolor
(256 aa),FASTA scores: opt: 266, E(): 1.9e-09, (32.25%
identity in 248 aa overlap); etc. Also similar to
P95060|Rv0712|MTCY210.31 hypothetical 32.7 KDA protein
from Mycobacterium tuberculosis (299 aa), FASTA scores:
opt: 243, E(): 5.9e-08, (30.6% identity in 304 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3703c"
/db_xref="EnsemblGenomes-Tr:CCP46528"
/db_xref="GOA:O69671"
/db_xref="InterPro:IPR005532"
/db_xref="InterPro:IPR016187"
/db_xref="InterPro:IPR017806"
/db_xref="InterPro:IPR024775"
/db_xref="InterPro:IPR032890"
/db_xref="InterPro:IPR034660"
/db_xref="InterPro:IPR042095"
/db_xref="UniProtKB/Swiss-Prot:O69671"
/protein_id="CCP46528.1"
/translation="MTSPEQLACHLARARARTLRLVDFDDAELCCQYDPLMSPLVWDL
AHIGQQEELWLLRGGDPGQPGLLPPAVEGLYDAFEHSRASRVELPLLSPARARSYCAT
VRSAALDALAALPEDGDSFVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAGR
PRMAGTSVLVAGGPFVLGVDAADEPCSLDNERPAHVVDVPAFRIGRVPVTNGEWQDFI
DDGGYTQSRWWSERGWQHRQRAGLTAPQFWRSGGRTRTRFGHVEDIPADEPVQHVSYF
EAEAYAAWAGARLPTEVEWEKACAWDPATGSRRRYPWGTEEPTDTYANLGGQTLRPAP
VGAYPAGASACGAEQMLGDVWEWTTSPLRPWPGFVPMVYERYSQPFFGGDYRVLRGGS
WAVEPAILRPSFRNWDHPYRRQIFAGVRLAWDI"
gene complement(4146888..4148186)
/gene="gshA"
/locus_tag="Rv3704c"
CDS complement(4146888..4148186)
/codon_start=1
/transl_table=11
/gene="gshA"
/locus_tag="Rv3704c"
/product="Glutamate--cysteine ligase GshA
(gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS)
(gamma-glutamyl-L-cysteine synthetase)"
/note="Rv3704c, (MTV025.052c), len: 432 aa. Possible
gshA,glutamate--cysteine ligase, similar to many e.g.
Q9A2Z2|CC3414 glutamate--cysteine ligase from Caulobacter
crescentus (453 aa), FASTA scores: opt: 404, E():
5.9e-17,(30.45% identity in 312 aa overlap); Q9SEH0|GSH1
gamma-glutamylcysteinyl synthetase precursor from Pisum
sativum (Garden pea) (499 aa), FASTA scores: opt: 400,
E(): 1.1e-16, (26.4% identity in 439 aa overlap);
Q9RH09|GSH gamma-glutamylcysteine synthetase from
Zymomonas mobilis (462 aa), FASTA scores: opt: 397, E():
1.6e-16, (28.95% identity in 304 aa overlap);
P46309|GSH1_ARATH|GSH1|AT4G23100|F7H19.290
glutamate--cysteine ligase from Arabidopsis thaliana
(Mouse-ear cress) (522 aa), FASTA scores: opt: 395, E():
2.3e-16, (27.25% identity in 385 aa overlap); etc. But
note that this putative protein is also similar to
Q9JMV4|GSHA putative glutathione synthetase (fragment)
from Bradyrhizobium japonicum (460 aa), FASTA scores: opt:
498,E(): 1.3e-22, (33.35% identity in 333 aa overlap) (no
significant publications found (August 2001)). Nucleotide
position 4147070 in the genome sequence has been
corrected,A:G resulting in L373L."
/db_xref="EnsemblGenomes-Gn:Rv3704c"
/db_xref="EnsemblGenomes-Tr:CCP46529"
/db_xref="GOA:P9WPK7"
/db_xref="InterPro:IPR006336"
/db_xref="InterPro:IPR014746"
/db_xref="InterPro:IPR017809"
/db_xref="InterPro:IPR035434"
/db_xref="UniProtKB/Swiss-Prot:P9WPK7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46529.1"
/translation="MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLG
RVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADG
VLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHS
GVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQ
STRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVP
FTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTL
VTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTELIG
AMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS"
gene complement(4148318..4148962)
/locus_tag="Rv3705c"
CDS complement(4148318..4148962)
/codon_start=1
/transl_table=11
/locus_tag="Rv3705c"
/product="Conserved protein"
/note="Rv3705c, (MTV025.053c), len: 214 aa. Conserved
protein, equivalent to Q9CB80|ML2320 hypothetical protein
from Mycobacterium leprae (215 aa) FASTA scores: opt:
1145,E(): 5.9e-68, (79.45% identity in 214 aa overlap).
Some similarity to the C-terminal end of
Q11053|PKNH_MYCTU|Rv1266c|MT1304|MTCY50.16 probable
serine/threonine-protein from Mycobacterium tuberculosis
(626 aa), FASTA scores: opt: 175, E(): 0.0005, (24.9%
identity in 201 aa overlap); and to the N-terminal end of
P23903|E13B_BACCI|GLCA glucan endo-1,3-beta-glucosidase A1
precursor from Bacillus circulans (682 aa), FASTA scores:
opt: 122, E(): 1.6, (25.6% identity in 164 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004). Predicted to be an
outer membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3705c"
/db_xref="EnsemblGenomes-Tr:CCP46530"
/db_xref="InterPro:IPR026954"
/db_xref="InterPro:IPR038232"
/db_xref="UniProtKB/TrEMBL:I6XI06"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46530.1"
/translation="MRIAAAVVSIGLAVIAGFAVPVADAHPSEPGVVSYAVLGKGSVG
NIVGAPMGWEAVFTRPFQAFWVELPACNNWVDIGLPEVYDDPDLASFNGATTQTSATD
QTHLVKQAVGVFASNDAADRAFHRVVDRTVGCSGQTTAIHLDDGTTQVWSFAGGPSTG
TDEAWTKQEAGTDRRCFVQTRLRENVLLQAKVCQSGNAGPAVNVLAGAMQNTLG"
gene complement(4149091..4149480)
/locus_tag="Rv3705A"
CDS complement(4149091..4149480)
/codon_start=1
/transl_table=11
/locus_tag="Rv3705A"
/product="Conserved hypothetical proline rich protein"
/note="Rv3705A, len: 129 aa. Conserved hypothetical
protein, similar to downstream ORF
O69674|Rv3706c|MTV025.054c conserved hypothetical proline
rich protein from Mycobacterium tuberculosis (106
aa),FASTA scores: opt: 245, E(): 0.00013, (40.7% identity
in 113 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3705A"
/db_xref="EnsemblGenomes-Tr:CCP46531"
/db_xref="GOA:I6YGY9"
/db_xref="UniProtKB/TrEMBL:I6YGY9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46531.1"
/translation="MTETPQPAAPPPSAATTSPPPSPQQEKPPRLYRAAAWVVIVAGI
VFTVAVIFFSGALVLGQGKCPYHRYYHHGMFRPVGPVAPGPGMGWVFGFPGGPPPPGM
GPGFPGGPGGPAVGPTGPGPTTAPARP"
gene complement(4149591..4149911)
/locus_tag="Rv3706c"
CDS complement(4149591..4149911)
/codon_start=1
/transl_table=11
/locus_tag="Rv3706c"
/product="Conserved hypothetical proline rich protein"
/note="Rv3706c, (MTV025.054c), len: 106 aa. Conserved
ypothetical pro-rich protein, similar to upstream ORF
Rv3705A (129 aa), and AAK48176|MT3808.1 hypothetical 13.0
KDA protein from Mycobacterium tuberculosis strain CDC1551
(129 aa), FASTA scores: opt: 245, E(): 4.4e-06, (40.7%
identity in 113 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3706c"
/db_xref="EnsemblGenomes-Tr:CCP46532"
/db_xref="GOA:I6X849"
/db_xref="UniProtKB/TrEMBL:I6X849"
/protein_id="CCP46532.1"
/translation="MRHMSETSETPTPPPHQTPKVFKAAAWVAIAAGTVFIVAVIFFT
GYILGKHAGHGGFHHRQHHQHPAMMLRPGSPHGGPAAVRPGPGPGGPGQVPSSVSPPA
TPAP"
gene complement(4150030..4151040)
/locus_tag="Rv3707c"
CDS complement(4150030..4151040)
/codon_start=1
/transl_table=11
/locus_tag="Rv3707c"
/product="Conserved hypothetical protein"
/note="Rv3707c, (MTV025.055c), len: 336 aa. Equivalent to
Q9CB79|ML2321 hypothetical protein from Mycobacterium
leprae (336 aa), FASTA scores: opt: 1948, E():
6.7e-110,(81.95% identity in 332 aa overlap); and
P41402|YASD_MYCSM hypothetical 35.9 KDA protein in the
aspartokinase gene cluster from Mycobacterium smegmatis
(333 aa), FASTA scores: opt: 1731, E(): 7.4e-97, (70.85%
identity in 333 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3707c"
/db_xref="EnsemblGenomes-Tr:CCP46533"
/db_xref="InterPro:IPR025442"
/db_xref="UniProtKB/TrEMBL:I6Y4C4"
/protein_id="CCP46533.1"
/translation="MLRIGPTAGTGTPTGDYGIGATDLCEFVEFPSQLLQVCGDSFAG
QGVGFGGWYAPVALHVDTESIDDPAGVRYTGVTGVGTPLLADPTPPGDSQLPAGVVQI
NRRNYLMVTTTKDLQPQNSRLVRAEAARGGWQTVSGSRRNAAYQDGRQTQISGYYDPV
PTPDSPTGWVYIVADSFTRGEPAVLYRATPESFTDRSRWQGWAGGPDGGWNKPPTPLW
PDQLGEMSIRQIDGQTVLSYFNASTGNMEVRVAHHPTSLGAAPVTTVVRHDEWPEPAE
SLPPPYDNRLAQPYGGYISPGSTIDELRIFVSQWDTRARQNGPYRVIQFAVNPFKPWS
DP"
gene complement(4151180..4152217)
/gene="asd"
/locus_tag="Rv3708c"
CDS complement(4151180..4152217)
/codon_start=1
/transl_table=11
/gene="asd"
/locus_tag="Rv3708c"
/product="Aspartate-semialdehyde dehydrogenase Asd (ASA
dehydrogenase) (ASADH) (aspartic semialdehyde
dehydrogenase) (L-aspartate-beta-semialdehyde
dehydrogenase)"
/note="Rv3708c, (MTV025.056c), len: 345 aa.
Asd,aspartate-semialdehyde dehydrogenase (see citation
below),equivalent to many e.g. P47730|DHAS_MYCBO|ASD from
Mycobacterium bovis (345 aa) FASTA scores: opt: 2150, E():
1.6e-124, (97.7% identity in 345 aa overlap); or
Q9JN40|ASD from Mycobacterium bovis (323 aa), FASTA
scores: opt: 2021,E(): 1.2e-116, (97.5% identity in 323 aa
overlap); Q9CB78|ASD|ML2322 from Mycobacterium leprae (351
aa), FASTA scores: opt: 1889, E(): 1.6e-108, (84.45%
identity in 347 aa overlap); P41404|DHAS_MYCSM|ASD from
Mycobacterium smegmatis (346 aa), FASTA scores: opt: 1801,
E(): 3.9e-103,(80.3% identity in 345 aa overlap); etc.
Contains PS01103 Aspartate-semialdehyde dehydrogenase
signature. Belongs to the aspartate-semialdehyde
dehydrogenase family."
/db_xref="EnsemblGenomes-Gn:Rv3708c"
/db_xref="EnsemblGenomes-Tr:CCP46534"
/db_xref="GOA:P9WNX5"
/db_xref="InterPro:IPR000319"
/db_xref="InterPro:IPR000534"
/db_xref="InterPro:IPR005986"
/db_xref="InterPro:IPR012080"
/db_xref="InterPro:IPR012280"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:2GUL"
/db_xref="PDB:3TZ6"
/db_xref="PDB:3VOS"
/db_xref="UniProtKB/Swiss-Prot:P9WNX5"
/inference="protein motif:PROSITE:PS01103"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46534.1"
/translation="MGLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRK
LAFRGQEIEVEDAETADPSGLDIALFSAGSAMSKVQAPRFAAAGVTVIDNSSAWRKDP
DVPLVVSEVNFERDAHRRPKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVS
GSGLAGVAELAEQARAVIGGAEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDG
SGETDEDQKLRFESRKILGIPDLLVSGTCVRVPVFTGHSLSINAEFAQPLSPERAREL
LDGATGVQLVDVPTPLAAAGVDESLVGRIRRDPGVPDGRGLALFVSGDNLRKGAALNT
IQIAELLTADL"
gene complement(4152218..4153483)
/gene="ask"
/locus_tag="Rv3709c"
CDS complement(4152218..4153483)
/codon_start=1
/transl_table=11
/gene="ask"
/locus_tag="Rv3709c"
/product="Aspartokinase Ask (aspartate kinase) [contains:
aspartokinase alpha subunit (Ask-alpha); and aspartokinase
beta subunit (Ask-beta)]"
/note="Rv3709c, (MTV025.057c), len: 421 aa.
Ask,aspartokinase (see citation below), equivalent to
Q9CB77|ask|ML2323 from Mycobacterium leprae (421 aa),
FASTA scores: opt: 2531, E(): 2e-140, (92.65% identity in
421 aa overlap); and P41403|AK_MYCSM|ask from
Mycobacterium smegmatis (421 aa), FASTA scores: opt: 2423,
E(): 4e-134,(88.1% identity in 421 aa overlap); and to
several other organisms e.g. Q9RQ25|ASKA from
Amycolatopsis mediterranei (421 aa), FASTA scores: opt:
2026, E(): 5.8e-111, (72.2% identity in 421 aa overlap).
Contains PS00324 Aspartokinase signature. Belongs to the
aspartokinase family. Alternative products: the alpha and
beta subunits of aspartokinase are produced by the use of
alternative initiation sites (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3709c"
/db_xref="EnsemblGenomes-Tr:CCP46535"
/db_xref="GOA:P9WPX3"
/db_xref="InterPro:IPR001048"
/db_xref="InterPro:IPR001341"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR005260"
/db_xref="InterPro:IPR018042"
/db_xref="InterPro:IPR027795"
/db_xref="InterPro:IPR036393"
/db_xref="InterPro:IPR041740"
/db_xref="PDB:3S1T"
/db_xref="PDB:4GO5"
/db_xref="PDB:4GO7"
/db_xref="UniProtKB/Swiss-Prot:P9WPX3"
/inference="protein motif:PROSITE:PS00324"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46535.1"
/translation="MALVVQKYGGSSVADAERIRRVAERIVATKKQGNDVVVVVSAMG
DTTDDLLDLAQQVCPAPPPRELDMLLTAGERISNALVAMAIESLGAHARSFTGSQAGV
ITTGTHGNAKIIDVTPGRLQTALEEGRVVLVAGFQGVSQDTKDVTTLGRGGSDTTAVA
MAAALGADVCEIYTDVDGIFSADPRIVRNARKLDTVTFEEMLEMAACGAKVLMLRCVE
YARRHNIPVHVRSSYSDRPGTVVVGSIKDVPMEDPILTGVAHDRSEAKVTIVGLPDIP
GYAAKVFRAVADADVNIDMVLQNVSKVEDGKTDITFTCSRDVGPAAVEKLDSLRNEIG
FSQLLYDDHIGKVSLIGAGMRSHPGVTATFCEALAAVGVNIELISTSEIRISVLCRDT
ELDKAVVALHEAFGLGGDEEATVYAGTGR"
gene 4153740..4155674
/gene="leuA"
/locus_tag="Rv3710"
CDS 4153740..4155674
/codon_start=1
/transl_table=11
/gene="leuA"
/locus_tag="Rv3710"
/product="2-isopropylmalate synthase LeuA
(alpha-isopropylmalate synthase) (alpha-IPM synthetase)
(IPMS)"
/note="Rv3710, (MTV025.058), len: 644 aa.
LeuA,alpha-isopropylmalate synthase (see citations
below),equivalent to Q9CB76|LEUA|ML2324 2-isopropylmalate
synthase from Mycobacterium leprae (607 aa), FASTA scores:
opt: 3291, E(): 3.7e-192, (80.7% identity in 642 aa
overlap). Also highly similar to many e.g.
P42455|LEU1_CORGL|LEUA from Corynebacterium glutamicum
(Brevibacterium flavum) (616 aa), FASTA scores: opt: 2547,
E(): 5.3e-147, (63.25% identity in 645 aa overlap);
O31046|LEU1_STRCO|LEUA from Streptomyces coelicolor (573
aa), FASTA scores: opt: 2226,E(): 1.5e-127, (57.8%
identity in 616 aa overlap); BAB49833|Q98HN3|MLR2792 from
Rhizobium loti (Mesorhizobium loti) (588 aa), FASTA
scores: opt: 1849, E(): 1.1e-104,(58.0% identity in 536 aa
overlap); etc. Equivalent to AAK48181 from Mycobacterium
tuberculosis strain CDC1551 (659 aa) but shorter 15 aa.
Contains PS00815 and PS00816 Alpha-isopropylmalate and
homocitrate synthases signatures 1 and 2. Belongs to the
alpha-IPM synthetase / homocitrate synthase family. K+ is
likely the physiological activator; Zn2+ and Cd2+ are
inhibitors."
/db_xref="EnsemblGenomes-Gn:Rv3710"
/db_xref="EnsemblGenomes-Tr:CCP46536"
/db_xref="GOA:P9WQB3"
/db_xref="InterPro:IPR000891"
/db_xref="InterPro:IPR002034"
/db_xref="InterPro:IPR005668"
/db_xref="InterPro:IPR013709"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR036230"
/db_xref="InterPro:IPR039371"
/db_xref="PDB:1SR9"
/db_xref="PDB:3FIG"
/db_xref="PDB:3HPS"
/db_xref="PDB:3HPX"
/db_xref="PDB:3HPZ"
/db_xref="PDB:3HQ1"
/db_xref="PDB:3U6W"
/db_xref="UniProtKB/Swiss-Prot:P9WQB3"
/inference="protein motif:PROSITE:PS00815"
/inference="protein motif:PROSITE:PS00816"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46536.1"
/translation="MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVN
RYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLL
VRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG
APRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPE
SYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLAN
RESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSR
GVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKL
DADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLP
RRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDD
GGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQ
AAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIA
PSITTASLRAVVSAVNRAAR"
gene complement(4155740..4156729)
/gene="dnaQ"
/locus_tag="Rv3711c"
CDS complement(4155740..4156729)
/codon_start=1
/transl_table=11
/gene="dnaQ"
/locus_tag="Rv3711c"
/product="Probable DNA polymerase III (epsilon subunit)
DnaQ"
/note="Rv3711c, (MTV025.059c), len: 329 aa. Probable
dnaQ,DNA polymerase III, epsilon subunit, similar to many
e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328 aa),
FASTA scores: opt: 509, E(): 4.2e-25, (41.6% identity in
315 aa overlap); Q9JYS6|NMB1451 from Neisseria
meningitidis (serogroup B) (and Q9JTR5|MA1665 from
serogroup A) (470 aa), FASTA scores: opt: 247, E():
2.6e-08, (33.15% identity in 172 aa overlap);
O83649|DP3E_TREPA|DNAQ|TP0643 from Treponema pallidum (215
aa), FASTA scores: opt: 240, E(): 3.7e-08, (29.65%
identity in 162 aa overlap); P03007|DP3E_ECOLI|MUTD|B0215
from Escherichia coli strain K12 (243 aa), FASTA scores:
opt: 208, E(): 4.5e-06, (28.4% identity in 169 aa
overlap); etc. Also similar to
Q10384|YL91_MYCTU|Rv2191|MTCY190.02 from Mycobacterium
tuberculosis (645 aa), FASTA scores: opt: 260, E():
5e-09,(28.55% identity in 301 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3711c"
/db_xref="EnsemblGenomes-Tr:CCP46537"
/db_xref="GOA:O69678"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR013520"
/db_xref="InterPro:IPR036397"
/db_xref="InterPro:IPR036420"
/db_xref="UniProtKB/TrEMBL:O69678"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46537.1"
/translation="MSHTWGRPASHQDRGWAVIDVETSGFRPGQARIISLAVLGLDAA
GRLEQSVVSLLNPKVDPGPTHVHGLTAAMLDGQPQFADIAGEVVDVLRGRTLVAHNVA
FDYAFLAAEAEIAEAELPVDFVMCTVELARRLQLGVDNLRLETLAAHWGVPQQRPHDA
FDDVRVLTGILAAALESARELDVWLPVHPVTRRRWPNGRVTHDELRPLKAVAARMACP
YLNPGRYVQGRPLVQGMRVGLAAEVKRTHEELVERILHAGLAYSDVVDRDTSLVVCNA
TAPEHGKGYHALQLGVPVMPEARFMECIGAVVGGASVEDFTDVAPVEKQLALF"
gene 4156981..4158222
/locus_tag="Rv3712"
CDS 4156981..4158222
/codon_start=1
/transl_table=11
/locus_tag="Rv3712"
/product="Possible ligase"
/note="Rv3712, (MTV025.060), len: 413 aa. Possible ligase
,equivalent to O69522|ML2326|MLCB2407.24c hypothetical
43.8 KDA protein (possible ligase) from Mycobacterium
leprae (411 aa), FASTA scores: opt: 2265, E(): 8e-129,
(84.25% identity in 413 aa overlap). Also similar to
ligases or hypothetical proteins e.g. Q9FCA1|2SCG58.12
putative ligase from Streptomyces coelicolor (412 aa),
FASTA scores: opt: 1168, E(): 6.7e-63, (45.8% identity in
406 aa overlap); P74303|SLR0938 hypothetical 50.2 KDA
protein from Synechocystis sp. strain PCC 6803 (459 aa),
FASTA scores: opt: 392, E(): 3.1e-16, (28.45% identity in
397 aa overlap); Q99ZX1|SPY1035 putative
UDP-N-acetylmuramyl tripeptide synthetase from
Streptococcus pyogenes (445 aa),FASTA scores: opt: 335,
E(): 8.1e-13, (29.2% identity in 438 aa overlap);
Q9CGJ0|YLBD hypothetical protein from Lactococcus lactis
(subsp. lactis) (Streptococcus lactis) (449 aa), FASTA
scores: opt: 324, E(): 3.8e-12, (28.75% identity in 445 aa
overlap); Q9ZGG7|MURC UDP-N-acetylmuramyl tripeptide
synthetase from Heliobacillus mobilis (455 aa), FASTA
scores: opt: 292,E(): 3.2e-10, (30.75% identity in 449 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3712"
/db_xref="EnsemblGenomes-Tr:CCP46538"
/db_xref="GOA:I6Y4C7"
/db_xref="InterPro:IPR013221"
/db_xref="InterPro:IPR013564"
/db_xref="InterPro:IPR036565"
/db_xref="UniProtKB/TrEMBL:I6Y4C7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46538.1"
/translation="MVTTRARLALAAGAGARWASRVTGRGAGAMIGGLVAMTLDRSIL
RQLGMGRRTVVVTGTNGKSTTTRMTAAALGTLGAVATNAEGANMDAGLVAALAAHRDA
ELAVLEVDEMHVPHISDAVDPAVVVLLNLSRDQLDRVGEINVIERTLRAGLARHPDAV
VVANCDDVLMTSAAYDSPNVVWVAAGGAWSNDSVSCPRSGEVIVRKAPSQEDHWYSTG
ADFKRPAPHWWFDDATLYGPDGLALPMRLALPGSVNRGNAAQAVAAAVALGADPAVAV
AAVCQVDEVAGRYRTVRIGAHQARILLAKNPAGWQEALAMVDKHADGVVIAVNGRVPD
GEDLSWLWDVRFEHFEKTRVVAAGERGTDLAVRLGYAGVEHTLVHDTVAAIASCPPGR
VEVVANYTAFLQLQRALARRG"
gene 4158227..4158922
/gene="cobQ2"
/locus_tag="Rv3713"
CDS 4158227..4158922
/codon_start=1
/transl_table=11
/gene="cobQ2"
/locus_tag="Rv3713"
/product="Possible cobyric acid synthase CobQ2"
/note="Rv3713, (MTV025.061), len: 231 aa. Possible
cobQ2,cobyric acid synthase, equivalent to
O69521|ML2327|MLCB2407.23c hypothetical 24.5 KDA protein
from Mycobacterium leprae (230 aa), FASTA scores: opt:
1313, E(): 4.7e-73, (86.1% identity in 230 aa overlap).
Also partially similar to several cobyric acid synthases
and hypothetical proteins e.g. Q9FCA0|2SCG58.13
hypothetical 26.2 KDA protein from Streptomyces coelicolor
(242 aa), FASTA scores: opt: 639, E(): 6.2e-32, (46.6%
identity in 234 aa overlap); Q9ZGG8|COBQ cobyric acid
synthase from Heliobacillus mobilis (252 aa), FASTA
scores: opt: 501, E(): 1.7e-23, (40.75% identity in 206 aa
overlap); BAB58053|SAV1891 hypothetical 27.4 KDA protein
from Staphylococcus aureus subsp. aureus Mu50 (243
aa),FASTA scores: opt: 400, E(): 2.3e-17, (35.95% identity
in 217 aa overlap); Q9CGJ1|COBQ cobyric acid synthase from
Lactococcus lactis (subsp. lactis) (Streptococcus lactis)
(261 aa), FASTA scores: opt: 353, E(): 1.8e-14, (35.3%
identity in 201 aa overlap); O26880|COBQ_METTH|MTH787
probable cobyric acid synthase from Methanobacterium
thermoautotrophicum (504 aa), FASTA scores: opt: 201, E():
5.6e-05, (33.35% identity in 171 aa overlap); etc. Also
similar to hypothetical mycobacterial proteins
O05811|COBB_MYCTU|Rv2848c|MT2914|MTCY24A1.09 (457 aa) and
P71842|Rv0789c|MTCY369.33c (199 aa). Seems to belong to
the COBB/COBQ family, COBQ subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3713"
/db_xref="EnsemblGenomes-Tr:CCP46539"
/db_xref="GOA:I6XI14"
/db_xref="InterPro:IPR011698"
/db_xref="InterPro:IPR017929"
/db_xref="InterPro:IPR029062"
/db_xref="InterPro:IPR033949"
/db_xref="UniProtKB/TrEMBL:I6XI14"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46539.1"
/translation="MVRIGLVLPDVMGTYGDGGNAVVLRQRLLLRGIAAEIVEITLAD
PVPDSLDLYTLGGAEDYAQRLATRHLRRYPGLQRAAGRGAPVLAICAAIQVLGHWYET
SSGDRVDGVGLLDVTTSPQDARTIGELVSKPLLAGLTQPLTGFENHRGGTVLGPGTSP
LGAVVKGAGNRAGDGFDGAVAGSVVATYMHGPCLARNPELADLLLSKVVGELAPLDLP
EVDLLRRERLSAR"
gene complement(4158931..4159821)
/locus_tag="Rv3714c"
CDS complement(4158931..4159821)
/codon_start=1
/transl_table=11
/locus_tag="Rv3714c"
/product="Conserved hypothetical protein"
/note="Rv3714c, (MTV025.062c), len: 296 aa. Conserved
hypothetical protein, highly similar to O07396|MAV346
MAV346 protein from Mycobacterium avium (346 aa) FASTA
scores: opt: 834, E(): 2.2e-46, (50.0% identity in 286 aa
overlap); and also highly similar to several proteins from
Mycobacterium tuberculosis e.g. O53421|Rv1073|MTV017.26
(283 aa), FASTA scores: opt: 869, E(): 1e-48, (51.1%
identity in 270 aa overlap); P71763|Rv1482c|MTCY277.03c
(339 aa), FASTA scores: opt: 775, E(): 1.3e-42, (46.35%
identity in 289 aa overlap); P96837|Rv3555c|MTCY06G11.02c
(289 aa), FASTA scores: opt: 733, E(): 5.9e-40, (44.15%
identity in 281 aa overlap); etc. Partially similar to
Q9Z512|UVRC_STRCO|SCC54.13c excinuclease ABC subunit C
from Streptomyces coelicolor (728 aa), FASTA scores: opt:
122,E(): 2.5, (27.0% identity in 174 aa overlap).
Equivalent to AAK48186 from Mycobacterium tuberculosis
strain CDC1551 (341 aa) but shorter 45 aa."
/db_xref="EnsemblGenomes-Gn:Rv3714c"
/db_xref="EnsemblGenomes-Tr:CCP46540"
/db_xref="GOA:O69681"
/db_xref="InterPro:IPR011335"
/db_xref="UniProtKB/TrEMBL:O69681"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46540.1"
/translation="MLISRMSVRSASMSVMGDVFIGSEAITAGRLTRHELQRWYQPMF
RGVYVSRRSVPTLWDRTVGAWLATRRHGVIAGNAASALHGAQWVDVDVAIELISPTTR
PQHGLVIRRETLCDDEITRVVGLPVTTLARTAYDLGRHLSRGEAVARLDALMRATPFS
RDDVLLLAKRHAGARGVRRLRDVLPLVDGGAASPKETWLRLLLIDAGLPVPTTQIPVV
HRWRNVGVLDMGWEKYMVAAEYDGDQHRSDRGRYVKDQRRLRKLAELGWIVIRVIAED
NPDDVVNRVRAALLARGWRP"
gene complement(4159889..4160500)
/gene="recR"
/locus_tag="Rv3715c"
CDS complement(4159889..4160500)
/codon_start=1
/transl_table=11
/gene="recR"
/locus_tag="Rv3715c"
/product="Probable recombination protein RecR"
/note="Rv3715c, (MTV025.063c), len: 203 aa. Probable
recR,recombination protein (see citation below),
equivalent to O69520|RECR_MYCLE|ML2329|MLCB2407.21
recombination protein from Mycobacterium leprae (203 aa),
FASTA scores: opt: 1246, E(): 9.2e-71, (91.6% identity in
202 aa overlap). Also highly similar to many e.g.
Q9XAI4|RECR_STRCO|SC66T3.29c from Streptomyces coelicolor
(199 aa), FASTA scores: opt: 952, E(): 1.9e-52, (68.3%
identity in 202 aa overlap); P24277|RECR_BACSU|RECM|recd
from Bacillus subtilis (198 aa), FASTA scores: opt:
696,E(): 1.8e-36, (50.5% identity in 198 aa overlap);
Q9ZNA2|RECR_DEIRA|DR0198 from Deinococcus radiodurans (220
aa), FASTA scores: opt: 673, E(): 5.2e-35, (49.75%
identity in 195 aa overlap); etc. Belongs to the RECR
family."
/db_xref="EnsemblGenomes-Gn:Rv3715c"
/db_xref="EnsemblGenomes-Tr:CCP46541"
/db_xref="GOA:P9WHI3"
/db_xref="InterPro:IPR000093"
/db_xref="InterPro:IPR003583"
/db_xref="InterPro:IPR006171"
/db_xref="InterPro:IPR015967"
/db_xref="InterPro:IPR023627"
/db_xref="InterPro:IPR023628"
/db_xref="InterPro:IPR034137"
/db_xref="UniProtKB/Swiss-Prot:P9WHI3"
/protein_id="CCP46541.1"
/translation="MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPSDIDRLTG
VLAKVRDGVRFCAVCGNVSDNERCRICSDIRRDASVVCIVEEPKDIQAVERTREFRGR
YHVLGGALDPLSGIGPDQLRIRELLSRIGERVDDVDVTEVIIATDPNTEGEATATYLV
RMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRVLA"
gene complement(4160512..4160913)
/locus_tag="Rv3716c"
CDS complement(4160512..4160913)
/codon_start=1
/transl_table=11
/locus_tag="Rv3716c"
/product="Conserved protein"
/note="Rv3716c, (MTV025.064c), len: 133 aa. Conserved
protein, equivalent to
O69519|Y1B6_MYCLE|ML2330|MLCB2407.20 hypothetical 11.9 KDA
protein from Mycobacterium leprae (116 aa), FASTA scores:
opt: 616, E(): 2.6e-21, (84.55% identity in 110 aa
overlap). Also highly similar to hypothetical ~12 kDa
proteins in the vicinity of recR from other bacteria e.g.
Q9XAI3|YT3D_STRCO|SC66T3.30c hypothetical 11.7 KDA protein
from Streptomyces coelicolor (115 aa), FASTA scores: opt:
379, E(): 9.5e-11, (50.8% identity in 122 aa overlap);
BAB56641|SAV0479 conserved hypothetical protein from
Staphylococcus aureus subsp. aureus Mu50 (105 aa) FASTA
scores: opt: 295, E(): 4.9e-07,(41.75% identity in 103 aa
overlap); Q99WC4P24281|YAAK_BACSU hypothetical 11.8 KDA
protein in DNAZ-RECR intergenic region from Bacillus
subtilis (107 aa), FASTA scores: opt: 272, E(): 5.3e-06,
(39.4% identity in 104 aa overlap);
P17577|YBAB_ECOLI|B0471|Z0588|ECS0524 from Escherichia
coli strain K and O157:H7 (109 aa), FASTA scores: opt:
256, E(): 2.8e-05, (38.0% identity in 100 aa overlap);
etc. Contains probable coiled-coil domain from aa 1-40.
Seems to belong to the UPF0133 family."
/db_xref="EnsemblGenomes-Gn:Rv3716c"
/db_xref="EnsemblGenomes-Tr:CCP46542"
/db_xref="GOA:P9WNR9"
/db_xref="InterPro:IPR004401"
/db_xref="InterPro:IPR036894"
/db_xref="PDB:5YRX"
/db_xref="UniProtKB/Swiss-Prot:P9WNR9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46542.1"
/translation="MQPGGDMSALLAQAQQMQQKLLEAQQQLANSEVHGQAGGGLVKV
VVKGSGEVIGVTIDPKVVDPDDIETLQDLIVGAMRDASQQVTKMAQERLGALAGAMRP
PAPPAAPPGAPGMPGMPGMPGAPGAPPVPGI"
gene 4161048..4161773
/locus_tag="Rv3717"
CDS 4161048..4161773
/codon_start=1
/transl_table=11
/locus_tag="Rv3717"
/product="Conserved hypothetical protein"
/note="Rv3717, (MTV025.065), len: 241 aa. Conserved
hypothetical protein, equivalent to O69518|MLCB2407.19c
(alias Q9CB75|ML2331 256 aa) hypothetical 25.1 KDA protein
from Mycobacterium leprae (244 aa), FASTA scores: opt:
1325, E(): 5.7e-74, (81.95% identity in 244 aa overlap).
Also similar to Q9KXK7|SCC53.04 putative secreted protein
from Streptomyces coelicolor (336 aa), FASTA scores: opt:
536, E(): 1.2e-25, (41.2% identity in 233 aa overlap); and
shows similarity with C-terminal end of other proteins
e.g. Q9RMZ0|PXO2-42 PXO2-42 protein from Bacillus
anthracis (531 aa), FASTA scores: opt: 191, E(): 0.00022,
(26.6% identity in 222 aa overlap); Q9RTX0 putative
N-acetylmuramoyl-L-alanine amidase (603 aa); Q9LCR4|CWLU
CWLU protein from Paenibacillus polymyxa (Bacillus
polymyxa) (524 aa), FASTA scores: opt: 141, E():
0.24,(29.2% identity in 219 aa overlap); etc. Shows
similarity with C-terminal end of
O53593|CWLM|Rv3915|MTV028.06 putative hydrolase from
Mycobacterium tuberculosis (406 aa), FASTA scores: opt:
176, E(): 0.0014, (25.7% identity in 218 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3717"
/db_xref="EnsemblGenomes-Tr:CCP46543"
/db_xref="GOA:I6Y4D2"
/db_xref="InterPro:IPR002508"
/db_xref="PDB:4LQ6"
/db_xref="PDB:4M6G"
/db_xref="PDB:4M6H"
/db_xref="PDB:4M6I"
/db_xref="UniProtKB/Swiss-Prot:I6Y4D2"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46543.1"
/translation="MIVGVLVAAATPIISSASATPANIAGMVVFIDPGHNGANDASIG
RQVPTGRGGTKNCQASGTSTNSGYPEHTFTWETGLRLRAALNALGVRTALSRGNDNAL
GPCVDERANMANALRPNAIVSLHADGGPASGRGFHVNYSAPPLNAIQAGPSVQFARIM
RDQLQASGIPKANYIGQDGLYGRSDLAGLNLAQYPSILVELGNMKNPADSALMESAEG
RQKYANALVRGVAGFLATQGQAR"
gene complement(4161815..4162258)
/locus_tag="Rv3718c"
CDS complement(4161815..4162258)
/codon_start=1
/transl_table=11
/locus_tag="Rv3718c"
/product="Conserved protein"
/note="Rv3718c, (MTV025.066c), len: 147 aa. Conserved
protein, equivalent to O69517|ML2332|MLCB2407.18
hypothetical 15.5 KDA protein from Mycobacterium leprae
(145 aa), FASTA scores: opt: 780, E(): 1.4e-44, (81.95%
identity in 144 aa overlap). Also highly similar to
Q9ZBJ2|SC9C7.18 conserved hypothetical protein from
Streptomyces coelicolor (147 aa) FASTA scores: opt:
475,E(): 1.7e-24, (52.05% identity in 146 aa overlap); and
showing some similarity to various proteins e.g.
P27538|PR2_PETCR pathogenesis-related protein 2 from
Petroselinum crispum (Parsley) (Petroselinum hortense)
(158 aa); P92918|ALL2_APIGR major allergen API G 2 from
Apium graveolens (Celery) (159 aa); etc. Thought to be
differentially expressed within host cells (see citation
below)."
/db_xref="EnsemblGenomes-Gn:Rv3718c"
/db_xref="EnsemblGenomes-Tr:CCP46544"
/db_xref="InterPro:IPR014488"
/db_xref="InterPro:IPR019587"
/db_xref="InterPro:IPR023393"
/db_xref="UniProtKB/TrEMBL:I6XI16"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46544.1"
/translation="MGQVSAASTILINAEPTATLDALADYETVRPKILSPHYSEYQVL
EGGKGRGTVAKWRLQATQSRVRDVQVNVDVAGHTVIEKDMNSSMVTNWTVAPAGPGSS
VTVKTTWTGAGGVKGFFEKTFAPLGLKKIQAEVLSNLKTELEGDA"
gene 4162306..4163718
/locus_tag="Rv3719"
CDS 4162306..4163718
/codon_start=1
/transl_table=11
/locus_tag="Rv3719"
/product="Conserved protein"
/note="Rv3719, (MTV025.067), len: 470 aa. Conserved
protein, equivalent to O69516|ML2333|MLCB2407.17c
hypothetical 51.8 KDA protein from Mycobacterium leprae
(459 aa), FASTA scores: opt: 2593, E(): 7.8e-161, (82.75%
identity in 458 aa overlap). Also some similarity to
Q9CU63|5830417J06RIK hypothetical protein (fragment) from
Mus musculus (Mouse) (479 aa) FASTA scores: opt: 454, E():
6.1e-22, (27.1% identity in 413 aa overlap); Q9HBA8
seladin-1 (unknown) from Homo sapiens (Human) (516
aa),FASTA scores: opt: 444, E(): 2.9e-21, (26.7% identity
in 412 aa overlap); O17397|DIMH_CAEEL|F52H2.6
diminuto-like protein from Caenorhabditis elegans (525
aa), FASTA scores: opt: 419, E(): 1.2e-19, (24.4% identity
in 434 aa overlap); Q39085|DIM_ARATH|DWF1 cell elongation
protein diminuto from Arabidopsis thaliana (Mouse-ear
cress) (561 aa) FASTA scores: opt: 318, E(): 4.8e-13,
(24.6% identity in 455 aa overlap); etc. Also some
similarity to Mycobacterium tuberculosis hypothetical
proteins P72056|Rv3790|MTCY13D12.24 (461 aa) FASTA scores:
opt: 174,E(): 0.00016; (25.1% identity in 426 aa overlap);
and Q50685|Rv2280|MTCY339_30c (459 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3719"
/db_xref="EnsemblGenomes-Tr:CCP46545"
/db_xref="GOA:O69686"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR016164"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="InterPro:IPR040165"
/db_xref="UniProtKB/TrEMBL:O69686"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46545.1"
/translation="MQGQLSRTRVYTVPVPGSAQSAYACGVERLLASYRSIPATASIR
LAKPTSNLFRARVKHDARGLDASGLTGVIGIDPEARTADVAGMCTYEDLIAATLHYGL
SPLVVPQLRTITLGGAVTGLGIESASFRNGLPHESVLEMDILTGAGELLTVSPGQHSD
LYRAFPNSYGTLGYSTRLRIQLEPVRPFVALRHIRFSSLTAMVAAMERIIDTGGLDGE
SVDYLDGVVFSADESYLCIGMQTSVPGPVSDYTGQDIYYRSIQHEAGIKEDRLTIHDY
FWRWDTDWFWCSRSFGAQNPRLRRWWPRRYRRSSVYWRLMALDQRFGIADRFENSRGR
PARERVVQDIEVPIERTCEFLEWFGENVPISPIWLCPLRLRDHAGWPLYPIRPDRSYV
NIGFWSSVPVGATEGATNRKIENKVSALDGHKSLYSDSFYTREEFDELYGGETYNTVK
KAYDPDSRLLDLYAKAVQRR"
gene 4163736..4164998
/locus_tag="Rv3720"
CDS 4163736..4164998
/codon_start=1
/transl_table=11
/locus_tag="Rv3720"
/product="Possible fatty acid synthase"
/note="Rv3720, (MTV025.068), len: 420 aa. Possible
fatty-acyl-phospholipid synthase, equivalent to
Q9CB74|ML2334 (alias O69515|MLCB2407.16c, 439 aa)
hypothetical protein from Mycobacterium leprae (420 aa)
FASTA scores: opt: 2508, E(): 4.7e-153, (86.45% identity
in 420 aa overlap). Also similar (especially at the
C-terminus) to various fatty-acid synthases (principally
cyclopropane-fatty-acyl-phospholipid synthases) and
hypothetical proteins e.g. Q9KZ58|SCE25.32c putative fatty
acid synthase from Streptomyces coelicolor (438 aa), FASTA
scores: opt: 1101, E(): 5.5e-63, (46.1% identity in 425 aa
overlap); P31049|YLP3_PSEPU hypothetical 44.7 KDA protein
from Pseudomonas putida (394 aa), FASTA scores: opt:
810,E(): 2.1e-44, (46.4% identity in 293 aa overlap);
Q9HT28|PA5546 hypothetical protein from Pseudomonas
aeruginosa (394 aa), FASTA scores: opt: 804, E():
5.2e-44,(40.7% identity in 371 aa overlap); Q9RSD7|DR2187
putative cyclopropane-fatty-acyl-phospholipid synthase
from Deinococcus radiodurans (462 aa), FASTA scores: opt:
747,E(): 2.6e-40, (35.95% identity in 409 aa overlap);
BAB50831|Q98ET6|MLL4091
cyclopropane-fatty-acyl-phospholipid synthase from
Rhizobium loti (Mesorhizobium loti) (422 aa), FASTA
scores: opt: 674, E(): 1.1e-35, (39.1% identity in 284 aa
overlap); P30010|CFA_ECOLI|CDFA|B1661
cyclopropane-fatty-acyl-phospholip synthase from
Escherichia coli strain K12 (381 aa), FASTA scores: opt:
530, E(): 1.7e-26, (33.65% identity in 312 aa overlap);
etc. Also similar to other proteins from Mycobacterium
tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa);
P96911|Rv0621|MTCY20H10 (354 aa);
O50416|LPQD|Rv3390|MTV004.48 (236 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv3720"
/db_xref="EnsemblGenomes-Tr:CCP46546"
/db_xref="GOA:O69687"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:O69687"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46546.1"
/translation="MAEILEIFTATGQHPLKFTAYDGSTAGQDDATLGLDLRTPRGAT
YLATAPGELGLARAYVSGDLQAHGVHPGDPYELLKTLTERVDFKRPSARVLANVVRSI
GVEHILPIAPPPQEARPRWRRMANGLLHSKTRDAEAIHHHYDVSNNFYEWVLGPSMTY
TCAVFPNAEASLEQAQENKYRLIFEKLRLEPGDRLLDVGCGWGGMVRYAARRGVRVIG
ATLSAEQAKWGQKAVEDEGLSDLAQVRHSDYRDVAETGFDAVSSIGLTEHIGVKNYPF
YFGFLKSKLRTGGLLLNHCITRHDNRSTSFAGGFTDRYVFPDGELTGSGRITTEIQQV
GLEVLHEENFRHHYAMTLRDWCGNLVEHWDDAVAEVGLPTAKVWGLYMAASRVAFERN
NLQLHHVLATKVDPRGDDSLPLRPWWQP"
gene complement(4164995..4166731)
/gene="dnaZX"
/locus_tag="Rv3721c"
CDS complement(4164995..4166731)
/codon_start=1
/transl_table=11
/gene="dnaZX"
/locus_tag="Rv3721c"
/product="DNA polymerase III (subunit gamma/tau) DnaZ/X"
/note="Rv3721c, (MTV025.069c), len: 578 aa. Probable
dnaZX,DNA polymerase III gamma (dnaZ) and tau (dnaX),
equivalent to O69514|DNAZX|ML2335 DNA polymerase III
subunit gamma/tau from Mycobacterium leprae (611 aa) FASTA
scores: opt: 2344,E(): 4.7e-118, (78.75% identity in 602
aa overlap). Also highly similar to many e.g. Q9RKL5|DNAZ
from Streptomyces coelicolor (784 aa) FASTA scores: opt:
1755, E(): 1.8e-86,(59.55% identity in 435 aa overlap);
Q9KGM4|DNAX|BH0034 from Bacillus halodurans (564 aa),
FASTA scores: opt: 946,E(): 2.5e-43, (37.4% identity in
460 aa overlap); P09122|DP3X_BACSU|DNAX|DNAH from Bacillus
subtilis (563 aa), FASTA scores: opt: 841, E(): 1e-37,
(30.8% identity in 510 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3721c"
/db_xref="EnsemblGenomes-Tr:CCP46547"
/db_xref="GOA:P9WNT9"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR008921"
/db_xref="InterPro:IPR012763"
/db_xref="InterPro:IPR022754"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNT9"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP46547.1"
/translation="MALYRKYRPASFAEVVGQEHVTAPLSVALDAGRINHAYLFSGPR
GCGKTSSARILARSLNCAQGPTANPCGVCESCVSLAPNAPGSIDVVELDAASHGGVDD
TRELRDRAFYAPVQSRYRVFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEK
VLPTIRSRTHHYPFRLLPPRTMRALLARICEQEGVVVDDAVYPLVIRAGGGSPRDTLS
VLDQLLAGAADTHVTYTRALGLLGVTDVALIDDAVDALAACDAAALFGAIESVIDGGH
DPRRFATDLLERFRDLIVLQSVPDAASRGVVDAPEDALDRMREQAARIGRATLTRYAE
VVQAGLGEMRGATAPRLLLEVVCARLLLPSASDAESALLQRVERIETRLDMSIPAPQA
VPRPSAAAAEPKHQPAREPRPVLAPTPASSEPTVAAVRSMWPTVRDKVRLRSRTTEVM
LAGATVRALEDNTLVLTHESAPLARRLSEQRNADVLAEALKDALGVNWRVRCETGEPA
AAASPVGGGANVATAKAVNPAPTANSTQRDEEEHMLAEAGRGDPSPRRDPEEVALELL
QNELGARRIDNA"
gene complement(4166821..4168128)
/locus_tag="Rv3722c"
CDS complement(4166821..4168128)
/codon_start=1
/transl_table=11
/locus_tag="Rv3722c"
/product="Conserved protein"
/note="Rv3722c, (MTV025.070c), len: 435 aa. Conserved
protein, equivalent to O69513|MLCB2407.14 (alias
Q9CB73|ML2336, 463 aa) hypothetical 46.8 KDA protein from
Mycobacterium leprae (426 aa), FASTA scores: opt:
2505,E(): 8.3e-154, (87.25% identity in 424 aa overlap).
Also highly similar to Q9RU17|DR1579 conserved
hypothetical protein from Deinococcus radiodurans (452
aa), FASTA scores: opt: 1162, E(): 3.1e-67, (44.8%
identity in 422 aa overlap); and partially similar to
Q9I371|PA1654 probable aminotransferase from Pseudomonas
aeruginosa (388 aa) FASTA scores: opt: 162, E(): 0.0078,
(25.85% identity in 348 aa overlap) and other
aminotransferases. N-terminus extended since first
submission (previously 408 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3722c"
/db_xref="EnsemblGenomes-Tr:CCP46548"
/db_xref="GOA:O69689"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR024551"
/db_xref="PDB:5C6U"
/db_xref="UniProtKB/TrEMBL:O69689"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46548.1"
/translation="MSFDSLSPQELAALHARHQQDYAALQGMKLALDLTRGKPSAEQL
DLSNQLLSLPGDDYRDPEGTDTRNYGGQHGLPGLRAIFAELLGIAVPNLIAGNNSSLE
LMHDIVAFSMLYGGVDSPRPWIQEQDGIKFLCPVPGYDRHFAITETMGIEMIPIPMLQ
DGPDVDLIEELVAVDPAIKGMWTVPVFGNPSGVTYSWETVRRLVQMRTAAPDFRLFWD
NAYAVHTLTLDFPRQVDVLGLAAKAGNPNRPYVFASTSKITFAGGGVSFFGGSLGNIA
WYLQYAGKKSIGPDKVNQLRHLRFFGDADGVRLHMLRHQQILAPKFALVAEVLDQRLS
ESKIASWTEPKGGYFISLDVLPGTARRTVALAKDVGIAVTEAGASFPYRKDPDDKNIR
IAPSFPSVPDLRNAVDGLATCALLAATETLLNQGLASSAPNVR"
gene complement(4168154..4168281)
/gene="C8"
/gene_synonym="mcr6"
ncRNA complement(4168154..4168281)
/gene="C8"
/gene_synonym="mcr6"
/product="Possible 4.5S RNA in signal recognition particle
(small cytoplasmic RNA) (SC-RNA)"
/note="C8, possible 4.5S RNA (See Arnvig and Young, 2009;
DiChiara et al., 2010), part of signal recognition
particle with protein Ffh. Alternate 3'-ends at positions
4168212 and 4168224."
/ncRNA_class="other"
gene 4168345..4168430
/gene="serV"
tRNA 4168345..4168430
/gene="serV"
/product="tRNA-Ser"
/anticodon=(pos:4168379..4168381,aa:Ser,seq:gga)
/note="codon recognized: UCC; serV, tRNA-Ser, anticodon
gga, length = 86"
gene 4168536..4169300
/locus_tag="Rv3723"
CDS 4168536..4169300
/codon_start=1
/transl_table=11
/locus_tag="Rv3723"
/product="Probable conserved transmembrane protein"
/note="Rv3723, (MTV025.071), len: 254 aa. Probable
conserved transmembrane protein, with hydrophobic
stretches at the N-terminus, and equivalent to
O69512|ML2337|MLCB2407.13c putative membrane protein from
Mycobacterium leprae (250 aa), FASTA scores: opt:
1029,E(): 1.2e-44, (64.45% identity in 253 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3723"
/db_xref="EnsemblGenomes-Tr:CCP46549"
/db_xref="GOA:O69690"
/db_xref="UniProtKB/Swiss-Prot:O69690"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46549.1"
/translation="MGRKVAVLWHASFSIGAGVLYFYFVLPRWPELMGDTGHSLGTGL
RIATGALVGLAALPVVFTLLRTRKPELGTPQLALSMRIWSIMAHVLAGALIVGTAISE
VWLSLDAAGQWLFGIYGAAAAIAVLGFFGFYLSFVAELPPPPPKPLKPKKPKQRRLRR
KKTAKGDEAEPEAAEEAENTELAAQEDEEAVEAPPESIESPGGEPESATREAPAAETA
TAEEPRGGLRNRRPTGKTSHRRRRTRSGVQVAKVDE"
gene 4169467..4169709
/gene="cut5a"
/locus_tag="Rv3724A"
CDS 4169467..4169709
/codon_start=1
/transl_table=11
/gene="cut5a"
/locus_tag="Rv3724A"
/product="Probable cutinase precursor [first part] Cut5a"
/note="Rv3724A, (MTV025.072), len: 80 aa. Probable
cut5a,truncated cutinase precursor, similar to N-terminal
end of others e.g. Q9KK87 serine esterase cutinase from
Mycobacterium avium (220 aa), FASTA scores: opt: 202, E():
1.5e-06, (56.45% identity in 62 aa overlap);
Q9XB09|RVD2-RV1758 protein (fragment) from Mycobacterium
bovis BCG (143 aa), FASTA scores: opt: 200, E():
1.5e-06,(61.4% identity in 57 aa overlap); and
Q00298|CUTI_BOTCI|CUTA cutinase precursor from Botrytis
cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores:
opt: 108, E(): 2.2, (40.4% identity in 52 aa overlap).
Also highly similar to others from Mycobacterium
tuberculosis e.g. O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E1
2.04 probable cutinase precursor (247 aa), FASTA scores:
opt: 189, E(): 1.2e-05, (58.0% identity in 50 aa overlap);
Q50664|CUT2_MYCTU|Rv2301|MT2358|MTCY339.08c probable
cutinase precursor (219 aa), FASTA scores: opt: 172, E():
0.00015, (59.2% identity in 49 aa overlap);
O06793|Rv1758|MTCY28.24|Z95890 hypothetical 17.9 KDA
protein (174 aa), FASTA scores: opt: 641, E():
2.7e-29,(57.2% identity in 166 aa overlap);
O06319|Rv3452|MTY13E12.05; and U00015_11 from
Mycobacterium leprae. Belongs to the cutinase family. Rest
of cutinase ORF continues as Rv3724B|CUT5B, frameshifting
could occur near position 4169668. Sequence has been
checked but no errors found."
/db_xref="EnsemblGenomes-Gn:Rv3724A"
/db_xref="EnsemblGenomes-Tr:CCP46550"
/db_xref="GOA:Q79FA5"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:Q79FA5"
/protein_id="CCP46550.1"
/translation="MDVIRWARRLAVVAGTAAAVTTPGLLSAHVPMVSAEPCPDVEVV
FARGTGEPPGIGSVGGLFVDALRFPGWRQVTRGLRR"
gene 4169606..4170169
/gene="cut5b"
/gene_synonym="clp7"
/gene_synonym="culp7"
/locus_tag="Rv3724B"
CDS 4169606..4170169
/codon_start=1
/transl_table=11
/gene="cut5b"
/gene_synonym="clp7"
/gene_synonym="culp7"
/locus_tag="Rv3724B"
/product="Probable cutinase [second part] Cut5b"
/note="Rv3724B, (MTV025.072), len: 187 aa. Probable
cut5b,truncated cutinase, similar to C-terminal end of
others e.g. Q9XB09|RVD2-RV1758 protein (fragment) from
Mycobacterium bovis BCG (143 aa) FASTA scores: opt:
335,E(): 3.4e-12, (53.25% identity in 92 aa overlap);
Q9KK87 serine esterase cutinase from Mycobacterium avium
(220 aa),FASTA scores: opt: 251, E(): 2.5e-07, (44.05%
identity in 168 aa overlap). Also similar to proteins from
Mycobacterium tuberculosis e.g. O06793|Rv1758|MTCY28.24
hypothetical 17.9 KDA protein (174 aa), FASTA scores: opt:
641, E(): 2.5e-29, (57.25% identity in 166 aa overlap);
O06319|Rv3452|MTCY13E12.05 hypothetical 23.1 KDA protein
(226 aa), FASTA scores: opt: 385, E(): 7.5e-15, (46.65%
identity in 165 aa overlap);
O06318|CUT3_MYCTU|Rv3451|MT3557|MTCY13E12.04 probable
cutinase precursor (247 aa), FASTA scores: opt: 307, E():
1.9e-10, (40.7% identity in 167 aa overlap);
Q10837|CUT1_MYCTU|Rv1984c|MT2037|MTCY39.35 probable
cutinase precursor (217 aa), FASTA scores: opt: 261, E():
6.7e-08, (50.9% identity in 169 aa overlap); etc; and
U00015_11 from Mycobacterium lepra. 5'-end of gene is
Rv3724A|CUT5A; frameshifting may occur near position
4169668."
/db_xref="EnsemblGenomes-Gn:Rv3724B"
/db_xref="EnsemblGenomes-Tr:CCP46551"
/db_xref="GOA:Q79FA4"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/TrEMBL:Q79FA4"
/protein_id="CCP46551.1"
/translation="MAPGSHLVLAASEDCSSTHCVSQVGAKSLGVYAVNYPASNDFAS
SDFPKTVIDGIRDAGSHIQSMAMSCPQTRQVLGGYSQGAAVAGYVTSAVVPPAVPVQA
VPAPMAPEVANHVAAVTLFGAPSAQFLGQYGAPPIAIGPLYQPKTLQLCADGDSICGD
GNSPVAHGLYAVNGMVGQGANFAASRL"
gene 4170214..4171143
/locus_tag="Rv3725"
CDS 4170214..4171143
/codon_start=1
/transl_table=11
/locus_tag="Rv3725"
/product="Possible oxidoreductase"
/note="Rv3725, (MTV025.073), len: 309 aa. Possible
reductase, similar to various oxidoreductases and
hypothetical proteins e.g. O34285|HPNA HPNA protein from
Zymomonas mobilis (337 aa), FASTA scores: opt: 317, E():
6.1e-11, (30.5% identity in 272 aa overlap);
Q9SZB3|F17M5.120|AT4G33360|AAK49584 hypothetical 37.9 KDA
protein from Arabidopsis thaliana (Mouse-ear cress) (344
aa), FASTA scores: opt: 314, E(): 9.1e-11, (30.35%
identity in 267 aa overlap); AAK59445|AT4G33360 putative
dihydrokaempferol 4-reductase from Arabidopsis thaliana
(Mouse-ear cress) (332 aa), FASTA scores: opt: 313, E():
1e-10, (30.8% identity in 263 aa overlap); Q9FSC6|CCR
cinnamoyl-CoA reductase from Populus trichocarpa (Western
balsam poplar) (338 aa), FASTA scores: opt: 305, E():
2.9e-10, (30.3% identity in 274 aa overlap); Q9M631
cinnamoyl CoA reductase from Populus tremuloides (Quaking
aspen) (337 aa), FASTA scores: opt: 291, E():
1.8e-09,(30.15% identity in 272 aa overlap);
P73212|DFRA_SYNY3|LR1706 putative
dihydroflavonol-4-reductase (dihydrokaempferol
4-reductase) from Synechocystis sp. strain PCC 6803 (343
aa), FASTA scores: opt: 278, E(): 1e-08, (29.35% identity
in 259 aa overlap); etc. Also some similarity to proteins
from Mycobacterium tuberculosis e.g.
P96816|Rv0139|MTCI5.13 hypothetical protein (340 aa) FASTA
scores: opt: 234, E(): 3.2e-06, (28.25% identity in 269 aa
overlap); and O06373|galE1|Rv3634c|MTCY15C10.18 probable
UDP-glucose 4-epimerase (314 aa) (27.3% identity in 194 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3725"
/db_xref="EnsemblGenomes-Tr:CCP46552"
/db_xref="GOA:O69692"
/db_xref="InterPro:IPR001509"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O69692"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46552.1"
/translation="MQNATMRVLVTGGTGFVGGWTAKAIADAGHSVRFLVRNPARLKT
SVAKLGVDVSDFAVADISDRDSVREALNGCDAVVHSAALVATDPRETSRMLSTNMAGA
QNVLGQAVELGMDPIVHVSSFTALFRPNLATLSADLPVAGGTDGYGQSKAQIEIYARG
LQDAGAPVNITYPGMVLGPPVGDQFGEAGEGVRSALWMHVIPGRGAAWLIVDVRDVAA
LHAALLESGRGPRRYTAGGHRIPVPELAKILGGSPAPRCWPSRCPIPRCVSRDRCWIK
PGPICLSILRSPRQVCSTTHRCRSPTIRRAKKN"
gene 4171421..4172614
/locus_tag="Rv3726"
CDS 4171421..4172614
/codon_start=1
/transl_table=11
/locus_tag="Rv3726"
/product="Possible dehydrogenase"
/note="Rv3726, (MTV025.074), len: 397 aa. Possible
dehydrogenase, similar to many e.g. O34788|YDJL
dehydrogenase from Bacillus subtilis (346 aa) FASTA
scores: opt: 401, E(): 3.4e-17, (29.6% identity in 395 aa
overlap); Q59696|ADH 2,3-butanediol dehydrogenase from
seudomonas putida (362 aa), FASTA scores: opt: 326, E():
1.3e-12,(29.45% identity in 387 aa overlap); AAG59541|YJJN
putative oxidoreductase from Escherichia coli strain
EDL933 (345 aa), FASTA scores: opt: 325, E(): 1.5e-12,
(30.85% identity in 256 aa overlap); Q9HWM8|PA4153
2,3-butanediol dehydrogenase from Pseudomonas aeruginosa
(363 aa), FASTA scores: opt: 324, E(): 1.8e-12, (30.5%
identity in 387 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3726"
/db_xref="EnsemblGenomes-Tr:CCP46553"
/db_xref="GOA:O69693"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O69693"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46553.1"
/translation="MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
HCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTPVVAMPLLR
RGNKEVHGIGLSTMAPGAYAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRG
EVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQ
DSPYAVAAGLGQGNRHLQSILDAFDLAVGTVERLQRLRLPWWHLWRAAEAAGAATPKR
PVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSDHIRPAMAINKEINLRFVLGYTP
LEFRDTLHMLADGKVNAAPLITGTVGLPGVAAAFDALGDPEAHAKIMIDPKSNAASPQ
PFRVE"
gene 4172955..4174763
/locus_tag="Rv3727"
CDS 4172955..4174763
/codon_start=1
/transl_table=11
/locus_tag="Rv3727"
/product="Possible oxidoreductase"
/note="Rv3727, (MTV025.075), len: 602 aa. Possible
oxidoreductase, similar to several plants phytoene
dehydrogenases/desaturases e.g. Q9HSE1|CRTI3|VNG0277G
phytoene dehydrogenase from Halobacterium sp. strain NRC-1
(541 aa), FASTA scores: opt: 299, E(): 1.1e-10, (29.85%
identity in 576 aa overlap); Q9FZL6|CITPDS1 phytoene
desaturase from Citrus unshiu (Satsuma orange) (553
aa),FASTA scores: opt: 164, E(): 0.018, (24.2% identity in
434 aa overlap); Q07356|CRTI_ARATH|PDS|AT4G14210|DL3145c
phytoene dehydrogenase precursor from Arabidopsis thaliana
(Mouse-ear cress) (566 aa), FASTA scores: opt: 163, E():
0.021, (23.95% identity in 434 aa overlap); etc.
N-terminal end similar to O69871|SC1C3.29 putative
protoporphyrinogen oxidase (fragment) from Streptomyces
coelicolor (61 aa),FASTA scores: opt: 154, E(): 0.012,
(60.45% identity in 43 aa overlap). The region between aa
155-310 is highly similar to Q49778|B2126_C1_169 from
Mycobacterium leprae (159 aa), FASTA scores: opt: 437,
E(): 1.5e-19, (46.6% identity in 161 aa overlap). And the
region between aa 462-546 is highly similar to the
N-terminal end of Q50003|U1764T from Mycobacterium leprae
(155 aa), FASTA scores: opt: 277, E(): 8.3e-10, (57.65%
identity in 85 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3727"
/db_xref="EnsemblGenomes-Tr:CCP46554"
/db_xref="GOA:O69694"
/db_xref="InterPro:IPR002937"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O69694"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46554.1"
/translation="MKPSPADTHVVIAGAGIAGLAAAMILAEAGVRVTLCEAASEAGG
KAKSLRLADGHPTEHSLRVYTDTYQTLLTLFSRIPTEHDRTVLDNLVGVSMVSATAQG
VIGRIAAPVALQRRRPTFARIIGKVVEPPRQLVRILLRGPMVIVGLAQRGVPATDVLH
YLYAHLRLLWMCRERLLAELGDISYADYLQLGCKSAQAQEFFSAVPRIYVAARTSAEA
AAIAPIVLKGLFRLKSNCPSALNDAKLPAIMMMDGPTSERMVDPWIRHLTRLGVDIHF
NTRVGDLEFDDGRVTALISSDGRRFACDYALLAVPYLTLRELAKSAHVKRYLPQLTQQ
HALALEASNGIQCFLRDLPATWPPFIRPGVVTTHLQSQWSLVCVLQGEGFWKNVRLPE
GTRYVLSITWSDVETPGPVFDRPLSECTPDEILTECLTQCGLDKSNVLGWRIDHELKH
LDEAEYEKVASELPPHLVSAPARGQRMVNFSPLTVLMPGARHRSPGICTSVPNLLLAG
EVIYSPDLTLFVPTMEKAACSGYLAARQIMNMVASHAAPLRIDFRDPAPFAVLRRVDR
WFWSRRRRPPDRSTFATPPTAMPAPSHLTDVDRSAS"
gene 4174873..4178070
/locus_tag="Rv3728"
CDS 4174873..4178070
/codon_start=1
/transl_table=11
/locus_tag="Rv3728"
/product="Probable conserved two-domain membrane protein"
/note="Rv3728, (MTV025.076), len: 1065 aa. Probable
conserved transmembrane protein organised into two
domains. Domain comprising the first ~510 aa residues is
similar to various multidrug resistance and efflux
proteins and contains sugar transport protein signature 1
(PS00216). Domain corresponding to the last 550 aa
residues contains cyclic nucleotide-binding domain
signature 2 (PS00889) and is very similar to
Q50733|YP65_MYCTU|Rv2565|MT2641|MTCY9C4.03c hypothetical
62.1 kDa protein from Mycobacterium tuberculosis (31.0%
identity in 546 aa overlap). Highly similar to
O05884|Rv3239c|MTCY20B11.14c probable transmembrane
transport protein from Mycobacterium tuberculosis (1048
aa) FASTA scores: opt: 4328, E(): 5e-201, (64.15% identity
in 1046 aa overlap). N-terminal end similar to
P71879|Rv2333c|MTCY3G12.01|MTCY98.02c (537 aa);
P71836|Rv0783c|MTCY369.27c (540 aa); and
O07753|Rv1877|MTCY180.41c (687 aa). Seems belong to the
sugar transporter family. Possibly member of major
facilitator superfamily (MFS)."
/db_xref="EnsemblGenomes-Gn:Rv3728"
/db_xref="EnsemblGenomes-Tr:CCP46555"
/db_xref="GOA:O69695"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR004638"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR018488"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O69695"
/inference="protein motif:PROSITE:PS00216"
/inference="protein motif:PROSITE:PS00889"
/protein_id="CCP46555.1"
/translation="MHTVATNNAAPVIAAGPVGPSRRRRRVHAPLTRRRQPSSSAVLL
VAAFGAFLAFLDSTIVNVAFPDIQRHFHSDISDLSWMLNAYNIVFAAFLVAAGRLADL
MGRKRVFILGVALFTVASGLCAIAESVGELVAFRVLQGIGAAVLVPASLGLVVEAFPA
ERRAHGVNLWGAAGAIAAGLGPPIGGALIEADGWRWVFLVNLPLGVFAVLAARRALVE
NRAAGRRRVPDVRGAVLLAFALGLLTLGLIKGPDWGWASLPTSGSLLAAAVAMVGFVM
SSRHHPAPMVEPTLLRIQSFVAGTGLTAVASAGFYAYLLTHVLFLNYVWGYTLLEAGM
AVAPAALVAAVVAAVLGRVADRHGYRFIVGIGALIWAASLLWYLKVVGSQPDFLGEWL
PGQILQGIGVGATFPLLGSAALARLAKGGSYATASAVTGTIRQVGAVIGVAVLVILVG
TPAPGAAEEALRHGWALAAICFVAVGIGALSLGRIRPVPAAVEPPPGPPVAPLGARRP
PRPAPVASPAAAVAPTPKTSREVNLLEALRFARPDTQQIELQAGSYLFHAGDVSDALY
VVRSGRLQVLAGDGAKDEVVAELGRGQVVGELGVLLDAPRSASVRAVRDSSLMRVTKA
EFAKIADAGVLGALAGVLAKRQHQTRVASQRTTPEVVVAVVGVDANAPVAMVATELCR
ALSTRLRAVAPGRVDCDGLERAEQTADRVVLHAAVGDARWREFCLRVADRVVLVASNP
AVPVAPLPTRATGADLVLAGRPAGREHRRAWEQLITPRSMHVVRREFVADDLRVLATR
IAGRSVGLVLSGGAARACAHLGVLEELEAAGVTVDRFAGTSMGAIIAALAASGLDAAG
VDAQIYEHFVRKSHGDYTLPSKGLIRGKRTQSTLRTIFGDHLVEELPKHFRCVSVDLL
ARRPVVHRQGPLADVVGCSMRLPFLYAPLPYGGTLHVDGGVLDNVPVTTLVGKDGPLI
AVNVASGGNPSPASGGHRRGKPRVPGLTDTLLRTMTISSAMASEKVLAQADLVIKPNP
IGVGLMEYHQIDRAREAGRIAAREALPQIMELVHG"
gene 4178285..4180615
/locus_tag="Rv3729"
CDS 4178285..4180615
/codon_start=1
/transl_table=11
/locus_tag="Rv3729"
/product="Possible transferase"
/note="Rv3729, (MTV025.077), len: 776 aa. Conserved
hypothetical protein, possible transferase, similar to
several hypothetical proteins and various transferases
e.g. O26919|MTH831 molybdenum cofactor biosynthesis MOAA
homolog from Methanobacterium thermoautotrophicum (497
aa), FASTA scores: opt: 697, E(): 4.8e-34, (30.7% identity
in 492 aa overlap); Q58036|Y619_METJA|MJ0619 hypothetical
protein from Methanococcus jannaschii (506 aa), FASTA
scores: opt: 670, E(): 2e-32, (30.6% identity in 497 aa
overlap); O27968|AF2316 conserved hypothetical protein
from Archaeoglobus fulgidus (518 aa), FASTA scores: opt:
477,E(): 6.4e-21, (29.4% identity in 500 aa overlap);
BAB60102|TVG0985801 molybdenum cofactor biosynthesis
protein from Thermoplasma volcanium (606 aa), FASTA
scores: opt: 402, E(): 2.1e-16, (28.1% identity in 509 aa
overlap); etc. C-terminus similar to methyltransferases
e.g. Q9S0N6|AVED C5-O-methyltransferase from Streptomyces
avermitilis (283 aa), FASTA scores: opt: 298, E():
1.9e-10,(31.5% identity in 292 aa overlap). Also similar
to the Mycobacterium tuberculosis proteins
P71673|YE05_MYCTU|Rv1405c|MT1449|MTCY21B4.22c (274 aa);
and Q50584|Rv1523|MTCY19G5.05c."
/db_xref="EnsemblGenomes-Gn:Rv3729"
/db_xref="EnsemblGenomes-Tr:CCP46556"
/db_xref="GOA:O69696"
/db_xref="InterPro:IPR007197"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR034474"
/db_xref="UniProtKB/TrEMBL:O69696"
/protein_id="CCP46556.1"
/translation="MFVEYTKSICPVCKVVVDAQVNIRHDKVYLRKRCREHGSFEALV
YGDAQMYLESARFNKPGTFPLRFQTEVRDGCPSDCGLCPDHKQHACLGLIEVNTHCNL
DCPICFADSGHQPDGYAITAAQCERMLDTLVAAEGEPEVVMFSGGEPTIHKQLLEFVD
AAQARPVKTVIINTNGIRLASDRRFVDQLATRNRPGHPVHIYLQFDGLDEATHRRIRG
HDLRDVKQRALDNCAAAGLTVSLVAAVERGLNEHELGAVIRHGMAQPGVQPVVFQPVT
HAGRHVQFDPLTRLTNSDIIACITAQLPEWFRPGDFFPVPCCFPSCRSITYLLTDGEH
VVPIPRLLNVEDYLDYVSNRVIPDLAIREALENLWSASAVPGTDTMTAQLQRATAALN
CAEGCGINLPEALTHLTDRVFAIVIQDFQDPYTLNVKQLMKCCVQQITPDGRLIPFCA
YNSVGYREQVREQLTGVPVPDIVPNAIPLAGLLADAPHGSKQANTGGSIARLAGPTRG
APMALPPQQIKACCADAYSRDIVALLLGDSFHPGGATLTRRLADQLGLRSTGDPRRVA
DIAAGPGASARLLASDYGVAVDGVDISEINVKRAQAAVAQTGLTERVRFHLGDAESVP
LPDDTFDALVCECAFCTFPDKNAAAQQFARILRPGGLAGITDVTVGDGGLPAELTPLA
AWVACIADARTVTDYTDILEGAGLRTRHIESHDESLLDMIDRIDARITALHVAAPEIL
ADNGIRHDSVRDFTALARAAVQTGRIGYTLMIAEKP"
gene complement(4180680..4181720)
/locus_tag="Rv3730c"
CDS complement(4180680..4181720)
/codon_start=1
/transl_table=11
/locus_tag="Rv3730c"
/product="Conserved hypothetical protein"
/note="Rv3730c, (MTV025.078c), len: 346 aa. Conserved
hypothetical protein, highly similar to Q9XAM1|SC4C6.19
hypothetical 38.5 KDA protein from Streptomyces coelicolor
(341 aa), FASTA scores: opt: 1313, E(): 2.2e-75, (59.25%
identity in 336 aa overlap); and similar to C-terminal end
of putative ATP-dependent DNA ligases e.g.
BAB49297|MLL2077 from Rhizobium loti (Mesorhizobium loti)
(833 aa), FASTA scores: opt: 550, E(): 5.3e-27, (31.3%
identity in 294 aa overlap); and BAB54816|MLL9625 from
Rhizobium loti (Mesorhizobium loti) plasmid pMLb (883 aa)
FASTA scores: opt: 492, E(): 2.5e-23, (33.7% identity in
291 aa overlap); etc. Also similar to the hypothetical
proteins e.g. Q9ZC15|SC1E6.07 hypothetical 34.9 KDA
protein from Streptomyces coelicolor (319 aa) FASTA
scores: opt: 537,E(): 1.5e-26, (34.95% identity in 292 aa
overlap); Q9XAF7|SC6G9.25 hypothetical 32.1 KDA protein
from Streptomyces coelicolor (293 aa), FASTA scores: opt:
474,E(): 1.3e-22, (33.75% identity in 302 aa overlap);
etc. Also highly similar to P95226|Rv0269c|MTCY06A4.13c
hypothetical 44.0 KDA protein from Mycobacterium
tuberculosis (397 aa), FASTA scores: opt: 940, E():
7.7e-52, (50.3% identity in 312 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3730c"
/db_xref="EnsemblGenomes-Tr:CCP46557"
/db_xref="InterPro:IPR014145"
/db_xref="UniProtKB/TrEMBL:O69697"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46557.1"
/translation="MAAAAEELDVDGIAVRLTSPDRMYFPKLGSHGTKRRLVEYYFAV
AGGPMLTALRDRPTHLQRFPDGVDGEQIYQKRIPRHRPDYLQTCRVTFPSGRMADALK
VTHPAAIVWAAQMGTITLHPWQVRCPDTEHPDELRIDLDPQPGTGFVEARTVAVDVLR
SVLDDLGLVGYPKTSGGRGIHVFLRIATDWDFVEVRRAGIALAREVERRAPDAVTTSW
WKEERGARIFIDFNQNARDRTMASAYSVRPTPIATVSMPLTWEELAGADPDDYTMTTV
PELVKIRDDPWAGMDDVAQSIAPLLDLAAADEERGLGDMPYPPNYPKMPGEPKRVQPS
RDTDLKGGNTSK"
gene 4181758..4182834
/gene="ligC"
/locus_tag="Rv3731"
CDS 4181758..4182834
/codon_start=1
/transl_table=11
/gene="ligC"
/locus_tag="Rv3731"
/product="Possible ATP-dependent DNA ligase LigC
(polydeoxyribonucleotide synthase [ATP]) (polynucleotide
ligase [ATP]) (sealase) (DNA repair protein) (DNA
joinase)"
/note="Rv3731, (MTV025.079), len: 358 aa. Possible
ligC,DNA ligase ATP-dependent (see citation below),
similar to numerous archaebacterial and eukaryotic
polynucleotide DNA ligases e.g. Q9XAM3|SC4C6.17c from
Streptomyces coelicolor (355 aa), FASTA scores: opt: 1429,
E(): 1.7e-82, (60.4% identity in 361 aa overlap);
BAB54870|MLL9685 from Rhizobium loti (Mesorhizobium loti)
plasmid pMLb (337 aa),FASTA scores: opt: 667, E():
1.2e-34, (40.35% identity in 347 aa overlap);
Q9HH07|DNLI_THEFM|LIG from Thermococcus fumicolans (559
aa), FASTA scores: opt: 335, E(): 1.4e-13,(27.25% identity
in 330 aa overlap); O59288|DNLI_PYRHO from Pyrococcus
horikoshii (559 aa), FASTA scores: opt: 307,E(): 8e-12,
(26.85% identity in 272 aa overlap); etc. Also similar to
Rv3062|MTCY22D7_19c|LIGB probable DNA ligase from
Mycobacterium tuberculosis (507 aa), FASTA score: (30.3%
identity in 356 aa overlap). Seems to belong to the
ATP-dependent DNA ligase family."
/db_xref="EnsemblGenomes-Gn:Rv3731"
/db_xref="EnsemblGenomes-Tr:CCP46558"
/db_xref="GOA:L0TDE1"
/db_xref="InterPro:IPR012309"
/db_xref="InterPro:IPR012310"
/db_xref="InterPro:IPR012340"
/db_xref="UniProtKB/Swiss-Prot:L0TDE1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46558.1"
/translation="MQLPVMPPVSPMLAKSVTAIPPDASYEPKWDGFRSICFRDGDQV
ELGSRNERPMTRYFPELVAAIRAELPHRCVIDGEIIIATDHGLDFEALQQRIHPAESR
VRMLADRTPASFIAFDLLALGDDDYTGRPFSERRAALVDAVTGSGADADLSIHVTPAT
TDMATAQRWFSEFEGAGLDGVIAKPPHITYQPDKRVMFKIKHLRTADCVVAGYRVHKS
GSDAIGSLLLGLYQEDGQLASVGVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAHV
AGQRTPRKNEFSRWNVGKDLSFVPLRPERVVEVRYDRMEGARFRHTAQFNRWRPDRDP
RSCSYAQLERPLTVSLSDIVPGLR"
gene 4182934..4183992
/locus_tag="Rv3732"
CDS 4182934..4183992
/codon_start=1
/transl_table=11
/locus_tag="Rv3732"
/product="Conserved protein"
/note="Rv3732, (MTV025.080), len: 352 aa. Conserved
protein. The region between aa 175-352 is highly similar
to the region between aa 72-257 of Q9KH39 hypothetical
55.5 KDA protein from Mycobacterium smegmatis (511 aa),
FASTA scores: opt: 1122, E(): 7.3e-63, (98.85% identity in
176 aa overlap). Also shows some similarity with Q55304
hypotheticalk protein from Synechocystis sp. strain PCC
6803 (387 aa), FASTA scores: opt: 201, E(): 2.7e-05,
(27.1% identity in 251 aa overlap); and P74254|SLR1173
hypothetical 52.5 KDA protein from Synechocystis sp.
strain PCC 6803 (463 aa), FASTA scores: opt: 201, E():
3.1e-05,(27.1% identity in 251 aa overlap). Also slightly
similar to MTCY01B2_21 and DPO1_MYCTU DNA polymerase I."
/db_xref="EnsemblGenomes-Gn:Rv3732"
/db_xref="EnsemblGenomes-Tr:CCP46559"
/db_xref="GOA:O69699"
/db_xref="InterPro:IPR019283"
/db_xref="UniProtKB/TrEMBL:O69699"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46559.1"
/translation="MAVLPACRLGLVVCVATAVITATMVLATPSYACACGAAVTAHGS
QATLNHEVALLHWDGTTETIVMQLAMNADTDNVALVVPTPTPAIVTTADQSTFGELDT
LSAPLIEHQRHWSLRRGVGASGPQEAAARAPHVLNQVRLGPLEATTLTGGDLSGLQTW
LSDNGYAIRPAVSAALDPYVRDGWAFVAIRLTSTDLIVGGLDPVRMTFRSSRLVYPMR
LSVAAQEPQHVTIFTLSDHRQQRTDADAATQTTHVRFAGDMSTAVRDPLLRELIGNHG
SYLTKVEVDIYQTSRISSDFTFGNAPNDDPYRQVVTVYDDVALPPLLLVVVSAIAVGA
AGGAVVVVLRRRRRAHTG"
gene complement(4184012..4184512)
/locus_tag="Rv3733c"
CDS complement(4184012..4184512)
/codon_start=1
/transl_table=11
/locus_tag="Rv3733c"
/product="Conserved hypothetical protein"
/note="Rv3733c, (MTV025.081c), len: 166 aa. Conserved
hypothetical protein, highly similar to Q9FCB0|2SCG58.03
putative mutt-like protein from Streptomyces coelicolor
(153 aa), FASTA scores: opt: 541, E(): 7.2e-29, (52.7%
identity in 148 aa overlap); and BAB49143|MLR1881
hypothetical protein from Rhizobium loti (Mesorhizobium
loti) (156 aa), FASTA scores: opt: 526, E():
7.2e-28,(52.65% identity in 150 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3733c"
/db_xref="EnsemblGenomes-Tr:CCP46560"
/db_xref="GOA:O69700"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR020084"
/db_xref="UniProtKB/TrEMBL:O69700"
/protein_id="CCP46560.1"
/translation="MPKLSAGVLLYRARAGVVDVLLAHPGGPFWAGKDDGAWSIPKGE
YTGGEDPWLAARREFSEEIGLCVPDGPRIDFGSLKQSGGKVVTVFGVRADLDITDARS
STFELDWPKGSGKMRKFPEVDRVSWFPVARARTKLLKGQRGFLDRLMAHPAVAGLSEG
PESLPR"
gene complement(4184526..4185890)
/gene="tgs2"
/locus_tag="Rv3734c"
CDS complement(4184526..4185890)
/codon_start=1
/transl_table=11
/gene="tgs2"
/locus_tag="Rv3734c"
/product="Putative triacylglycerol synthase
(diacylglycerol acyltransferase) Tgs2"
/note="Rv3734c, (MTV025.082c), len: 454 aa. Putative
tgs2,triacylglycerol synthase (See Daniel et al., 2004),
highly similar to O69707|Y1E0_MYCTU|Rv3740c|MT3848|MTV025.
088c hypothetical protein from Mycobacterium tuberculosis
(448 aa), FASTA scores: opt: 1917, E(): 1.3e-111, (61.4%
identity in 451 aa overlap); and similar to many other
proteins from Mycobacterium tuberculosis (strains H37Rv
and CDC1551) e.g. P71694|YE43_MYCTU|Rv1425|MT1468|MTCY21B4
.43|MTCY493.29c (459 aa), FASTA scores: opt: 824, E():
1.1e-43, (36.5% identity in 460 aa overlap);
Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.25c (445 aa) FASTA
scores: opt: 766, E(): 4.1e-40, (36.4% identity in 453 aa
overlap); etc. Also similar to Q9RIU8|SCM11.13c
hypothetical 47.1 KDA protein from Streptomyces coelicolor
(446 aa), FASTA scores: opt: 331, E(): 4.3e-13, (32.9%
identity in 468 aa overlap); and Q9X7A8|ML1244|MLCB1610.05
conserved membrane protein from Mycobacterium leprae (491
aa), FASTA scores: opt: 296, E(): 7e-11, (28.35% identity
in 413 aa overlap). Contains PS00339 Aminoacyl-transfer
RNA synthetases class-II signature 2. Start site chosen by
homology, but may extend further upstream to 93257."
/db_xref="EnsemblGenomes-Gn:Rv3734c"
/db_xref="EnsemblGenomes-Tr:CCP46561"
/db_xref="GOA:P9WKC7"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WKC7"
/inference="protein motif:PROSITE:PS00339"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46561.1"
/translation="MDLMMPNDSMFLFIESREHPMHVGGLSLFEPPQGAGPEFVREFT
ERLVANDEFQPMFRKHPATIGGGIARVAWAYDDDIDIDYHVRRSALPSPGRVRDLLEL
TSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHALIDGVSAMKLAQRTLSADPD
DAEVRAIWNLPPRPRTRPPSDGSSLLDALFKMAGSVVGLAPSTLKLARAALLEQQLTL
PFAAPHSMFNVKVGGARRCAAQSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIE
RNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCNLATHVDDPAQRIQTISASMDGN
KKVLSELPQLQVLALSALNMAPLTLAGVPGFLSAVPPPFNIVISNVPGPVDPLYYGTA
RLDGSYPLSNIPDGQALNITLVNNAGNLDFGLVGCRRSVPHLQRLLAHLESSLKDLEQ
AVGI"
gene 4186089..4186577
/locus_tag="Rv3735"
CDS 4186089..4186577
/codon_start=1
/transl_table=11
/locus_tag="Rv3735"
/product="Conserved hypothetical protein"
/note="Rv3735, (MTV025.083), len: 162 aa. Conserved
hypothetical protein, highly similar to several bacterial
hypothetical proteins e.g.
Q9UX41|ORF-C09_016|SSO0651|AAK40956 from Sulfolobus
solfataricus (163 aa), FASTA scores: opt: 627, E():
1.2e-34, (55.9% identity in 161 aa overlap); O26795|MTH699
from Methanobacterium thermoautotrophicum (168 aa), FASTA
scores: opt: 616, E(): 6.7e-34, (56.1% identity in 155 aa
overlap); |Q9Y9J9|APE2289 from Aeropyrum pernix (191
aa),FASTA scores: opt: 591, E(): 3.4e-32, (54.65% identity
in 161 aa overlap) ; etc. Contains PS00435 Peroxidases
proximal heme-ligand signature."
/db_xref="EnsemblGenomes-Gn:Rv3735"
/db_xref="EnsemblGenomes-Tr:CCP46562"
/db_xref="InterPro:IPR007153"
/db_xref="InterPro:IPR036902"
/db_xref="UniProtKB/TrEMBL:O69702"
/inference="protein motif:PROSITE:PS00435"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46562.1"
/translation="MSLAWDVVSVDKPDDVNVVIGQAHFIKAVEDLHEAMVGVSPSLR
FGLAFCEASGPRLVRHTGNDGDLVELATRTALAIAAGHSFVIFLREGFPINILNPVQA
VPEVCTIYCATANPVDVVVAVTPHGRGIVGVVDGQTPLGVETDRDIAQRRDLLRAIGY
KL"
gene 4186634..4187695
/locus_tag="Rv3736"
CDS 4186634..4187695
/codon_start=1
/transl_table=11
/locus_tag="Rv3736"
/product="Transcriptional regulatory protein (probably
AraC/XylS-family)"
/note="Rv3736, (MTV025.084), len: 353 aa. Probable
transcriptional regulator, araC/xylS family, similar to
many transcriptional regulators and hypothetical proteins
e.g. CAC38740 hypothetical 35.4 KDA protein from
Bradyrhizobium japonicum (318 aa), FASTA scores: opt:
438,E(): 2e-20, (29.4% identity in 306 aa overlap);
Q9HZ25|PA3215 probable transcriptional regulator from
Pseudomonas aeruginosa (337 aa), FASTA scores: opt:
395,E(): 1.1e-17, (30.3% identity in 320 aa overlap);
Q9HTN1|PA5324 probable transcriptional regulator from
Pseudomonas aeruginosa (356 aa), FASTA scores: opt:
313,E(): 1.8e-12, (25.85% identity in 329 aa overlap);
Q9Z3Y6|PHBR transcriptional regulator PHBR from
Pseudomonas sp. 61-3 (379 aa), FASTA scores: opt: 271,
E(): 8.3e-10,(22.95% identity in 357 aa overlap); etc.
Also highly similar to
Q06861|VIRS_MYCTU|Rv3082c|MTV013.03c possible
virulence-regulating protein from Mycobacterium
tuberculosis (340 aa), FASTA scores: opt: 656, E():
3.7e-34, (36.95% identity in 333 aa overlap); and similar
to other hypothetical mycobacterial proteins e.g.
P71663|YD95_MYCTU|Rv1395|MT1440|MTCY21B4.12 (344 aa).
Contains helix-turn-helix motif at aa 245-266 (Score
1140,+3.07 SD). Seems belong to the AraC/XylS family of
transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3736"
/db_xref="EnsemblGenomes-Tr:CCP46563"
/db_xref="GOA:O69703"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR018060"
/db_xref="InterPro:IPR032687"
/db_xref="UniProtKB/TrEMBL:O69703"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46563.1"
/translation="MSVVRGTALANYPSLVAGLGGDPATLLRAAGVRDQDVGNYDAFI
SIRAAIRAIESAAAVTATMDFGRRLAQRQGIEILGPVGVAARTAATVGDALAIFNTFM
AAYSPVIAIRITPLAGQRSFIALEFLLDEPASYPQTMELALGVALGVIRLLLGADYAP
LAVHLPHDPLTPEAFYLQYFGCRPYFAERVGGFTMRTADLSRPLNRDDVAHRVVVDYL
SSITPLGEGIVESVRTIVRQLLPTGAATLNVVAEQFHLHPKTLQRRLAEENTTFVILV
DRVRKDVADRYLRTTGIGLTHLARELGYAEQSVLTRSCKRWFGTGPAAYRNQARLQTT
VSAPGSGRGPNPGNVSVSC"
gene 4187699..4189288
/locus_tag="Rv3737"
CDS 4187699..4189288
/codon_start=1
/transl_table=11
/locus_tag="Rv3737"
/product="Probable conserved transmembrane protein"
/note="Rv3737, (MTV025.085), len: 529 aa. Probable
conserved transmembrane protein, similar to others and
also some hypothetical proteins e.g. AAK61331|THRE
threonine export carrier from Corynebacterium glutamicum
(Brevibacterium flavum) (489 aa), FASTA scores: opt:
773,E(): 1.8e-36, (37.25% identity in 424 aa overlap);
Q9X8J0|SCE9.17 putative membrane protein from Streptomyces
coelicolor (578 aa), FASTA scores: opt: 642, E():
5.4e-29,(31.6% identity in 481 aa overlap) (shorter 119 aa
at N-terminus); Q9CJU6|PM1895 hypothetical protein from
Pasteurella multocida (262 aa), FASTA scores: opt:
233,E(): 4.1e-06, (25.0% identity in 256 aa overlap);
Q9S267|SCI30A.06 putative integral membrane protein from
Streptomyces coelicolor (297 aa), FASTA scores: opt:
163,E(): 0.042, (29.65% identity in 263 aa overlap); etc.
Also partially similar to
O05435|Rv3910|MTCY15F10.01c|MTV028.01 hypothetical 123.6
KDA protein from Mycobacterium tuberculosis (1184 aa)
(34.4% identity in 125 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3737"
/db_xref="EnsemblGenomes-Tr:CCP46564"
/db_xref="GOA:O69704"
/db_xref="InterPro:IPR010619"
/db_xref="InterPro:IPR024528"
/db_xref="UniProtKB/TrEMBL:O69704"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46564.1"
/translation="MDQDRSDNTALRRGLRIALRGRRDPLPVAGRRSRTSGGIDDLHT
RKVLDLTIRLAEVMLSSGSGTADVVATAQDVAQAYQLTDCVVDITVTTIIVSALATTD
TPPVTIMRSVRTRSTDYSRLAELDRLVQRITSGGVAVDQAHEAMDELTERPHPYPRWL
ATAGAAGFALGVAMLLGGTWLTCVLAAVTSGVIDRLGRLLNRIGTPLFFQRVFGAGIA
TLVAVAAYLIAGQDPTALVATGIVVLLSGMTLVGSMQDAVTGYMLTALARLGDALFLT
AGIVVGILISLRGVTNAGIQIELHVDATTTLATPGMPLPILVAVSGAALSGVCLTIAS
YAPLRSVATAGLSAGLAELVLIGLGAAGFGRVVATWTAAIGVGFLATLISIRRQAPAL
VTATAGIMPMLPGLAVFRAVFAFAVNDTPDGGLTQLLEAAATALALGSGVVLGEFLAS
PLRYGAGRIGDLFRIEGPPGLRRAVGRVVRLQPAKSQQPTGTGGQRWRSVALEPTTAD
DVDAGYRGDWPATCTSATEVR"
gene complement(4189285..4190232)
/gene="PPE66"
/locus_tag="Rv3738c"
CDS complement(4189285..4190232)
/codon_start=1
/transl_table=11
/gene="PPE66"
/locus_tag="Rv3738c"
/product="PPE family protein PPE66"
/note="Rv3738c, (MTV025.086c), len: 315 aa. PPE66, Member
of the Mycobacterium tuberculosis PPE family, highly
similar to many e.g. O53265|Rv3018c|MTV012.32c (434
aa),FASTA scores: opt: 464, E(): 2.2e-17, (47.05% identity
in 338 aa overlap). Probably a continuation of the
upstream ORF MTV025.87c|Rv3739c|PPE67. At position
97470-72 a stop codon is present which interrupts a
possibly longer ORF,observed in related ORFs MTV012_32 or
MTCY21B4_4. The sequence has been checked and no errors
were detected. A similar situation, but with a frameshift
separating the ORFs is found in MTV012_36/MTV012_35.
Sequence similarity is also seen with MTCY251_15;
MTCY261_19; MLCB2492_30 from Mycobacterium leprae;
MTCY10G2_10; MTY21C12_9; MTCI125_26; MTCY164_36;
MTCY6A4_1."
/db_xref="EnsemblGenomes-Gn:Rv3738c"
/db_xref="EnsemblGenomes-Tr:CCP46565"
/db_xref="GOA:P9WHX1"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHX1"
/protein_id="CCP46565.1"
/translation="MTTAYASALAAMPTLTELAANHTSHAVLLGTNFFGINTIPIALN
EADYARMWIQAATTMSIYEGTSDAALASAPQTTPAPVLFNGGAGVASALPAISAATLD
PASIIGIIIEILIQLFLISLEILFAIVAYTIIIVLILPLVIFAYAIVFAVLAIIFGPP
LLVIASPFVLTGSVIAVPTSLSTSLSTAVPIGVGQYLADLASADAQAIEVGLKTADVA
PVAVRPAAAPPLRESAAVRPEARLVSAVAPAPAGTSASVLASDRGAGVLGFAGTAGKE
SVGRPAGLTTLAGGEFGGSPSVPMVPASWEQLVGAGEAG"
gene complement(4190284..4190517)
/gene="PPE67"
/locus_tag="Rv3739c"
CDS complement(4190284..4190517)
/codon_start=1
/transl_table=11
/gene="PPE67"
/locus_tag="Rv3739c"
/product="PPE family protein PPE67"
/note="Rv3739c, (MTV025.087c), len: 77 aa. PPE67, Member
of the Mycobacterium tuberculosis PE family, showing high
homology with O53269|Rv3022c|MTV012.36c (82 aa) FASTA
scores: opt: 398, E(): 1.2e-19, (74.0% identity in 77 aa
overlap); and similar to the N-termini of other PPE
proteins e.g. O53265|Rv3018c|MTV012.32c (434 aa) FASTA
scores: opt: 398, E(): 4.8e-19, (74.0% identity in 77 aa
overlap). ORF ends at the stop codon at position
97470,which is not present in similar ORFs: MTV012_32, or
MTCY21B4_4. Sequence homology with MTV012_32, and
MTCY21B4_4 continues in the downstream ORF
MTV025.086c|Rv3738c|PPE66. Sequence was checked, but no
errors were detected. A similar situation, but with a
frameshift separating the ORFs, is found in
MTV012_36/MTV012_35. Also ORF MTV025.87c shows similarity
to MTV03 _14; MTCY6A4_1; MTV035_8; MTV037_17; MLCB2492_30;
MTCY261_19; MTCY251_15; MTCY3A2_23; MTCY28_16; etc."
/db_xref="EnsemblGenomes-Gn:Rv3739c"
/db_xref="EnsemblGenomes-Tr:CCP46566"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/TrEMBL:Q79FA2"
/protein_id="CCP46566.1"
/translation="MTAPIWFASPPEVHSALLSAGPGPASLQAAAAEWTSLSAEYASA
AQELTAVLAAVQGGAWEGPSAEAYVAAHLPYLA"
gene complement(4190833..4192179)
/locus_tag="Rv3740c"
CDS complement(4190833..4192179)
/codon_start=1
/transl_table=11
/locus_tag="Rv3740c"
/product="Possible triacylglycerol synthase
(diacylglycerol acyltransferase)"
/note="Rv3740c, (MTV025.088c), len: 448 aa. Possible
triacylglycerol synthase (See Daniel et al., 2004), highly
similar to several other Mycobacterium tuberculosis
hypothetical proteins e.g.
O69701|Y1D4_MYCTU|Rv3734c|MT3839|MTV025.082c (454 aa)
FASTA scores: opt: 1917, E(): 2.3e-112, (61.4% identity in
451 aa overlap); Q50680|YM85_MYCTU|Rv2285|MT2343|MTCY339.2
5c (445 aa) FASTA scores: opt: 858, E(): 3.4e-46, (37.4%
identity in 460 aa overlap);
Q10554|Y895_MYCTU|Rv0895|MT0919|MTCY31.23 (505 aa), FASTA
scores: opt: 767, E(): 1.9e-40, (44.3% identity in 467 aa
overlap); MTCY31_25; MTCY28_26; MTCY493_29; MTCY21B4_43;
MTCY8D5_16; MTCY3A2_28; MTV013_8; MTY13E12_33; MTV013_9;
MTY20B11_9; etc. Also similar to Q9RIU8|SCM11.13c
hypothetical 47.1 KDA protein from Streptomyces coelicolor
(446 aa), FASTA scores: opt: 319, E(): 1.7e-12, (30.9%
identity in 453 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3740c"
/db_xref="EnsemblGenomes-Tr:CCP46567"
/db_xref="GOA:P9WKA5"
/db_xref="InterPro:IPR004255"
/db_xref="InterPro:IPR009721"
/db_xref="InterPro:IPR014292"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WKA5"
/protein_id="CCP46567.1"
/translation="MSPIDALFLSAESREHPLHVGALQLFEPPAGAGRGFVRETYQAM
LQCREIAPLFRKRPTSLHGALINLGWSTDADVDLGYHARRSALPAPGRVRELLELTSR
LHSNLLDRHRPLWETHVIEGLRDGRFAIYSKMHHALVDGVSGLTLMRQPMTTDPIEGK
LRTAWSPATQHTAIKRRRGRLQQLGGMLGSVAGLAPSTLRLARSALIEQQLTLPFGAP
HTMLNVAVGGARRCAAQSWPLDRVKAVKDAAGVSLNDVVLAMCAGALREYLDDNDALP
DTPLVAMVPVSLRTDRDSVGGNMVGAVLCNLATHLDDPADRLNAIHASMRGNKNVLSQ
LPRAQALAVSLLLLSPAALNTLPGLAKATPPPFNVCISNVPGAREPLYFNGARMVGNY
PMSLVLDGQALNITLTSTADSLDFGVVGCRRSVPHVQRVLSHLETSLKELERAVGL"
gene complement(4192179..4192853)
/locus_tag="Rv3741c"
CDS complement(4192179..4192853)
/codon_start=1
/transl_table=11
/locus_tag="Rv3741c"
/product="Possible oxidoreductase"
/note="Rv3741c, (MTV025.089c), len: 224 aa. Possible
oxidoreductase, probably combines with product of upstream
ORF MTV025.090c to form a functional monooxygenase, highly
similar to C-terminal end of various oxidoreductases e.g.
Q9APW3 aromatic-ring hyroxylase from Pseudomonas
aeruginosa (508 aa), FASTA scores: opt: 549, E(): 5.9e-28,
(56.1% identity in 155 aa overlap); Q9A588|CC2569
monooxygenase (flavin-binding family) from Caulobacter
crescentus (498 aa), FASTA scores: opt: 487, E(): 5.6e-24,
(39.55% identity in 225 aa overlap); Q9RZT0|DRB0033
arylesterase/monoxygenase from Deinococcus radiodurans
(833 aa), FASTA scores: opt: 460, E(): 4.7e-22, (38.5%
identity in 226 aa overlap); etc. Also similar to
C-terminal end of Mycobacterium tuberculosis proteins
(generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14
hypothetical 55.3 KDA protein (489 aa), FASTA scores: opt:
542, E(): 1.6e-27, (50.0% identity in 162 aa overlap);
O53762|Rv0565c|MTV039.03c putative monoxygenase (486
aa),FASTA scores: opt: 462, E(): 2.2e-22, (37.15% identity
in 226 aa overlap); O53300|Rv3083|MTV013.04 monoxygenase
(495 aa), FASTA scores: opt: 462, E(): 2.2e-22, (45.65%
identity in 173 aa overlap); etc. Note similarity to
MTCY01A6.14 and MTV013.04 continue in upstream ORF
(MTV025.090c) after a gap of ~100 aa."
/db_xref="EnsemblGenomes-Gn:Rv3741c"
/db_xref="EnsemblGenomes-Tr:CCP46568"
/db_xref="GOA:O69708"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O69708"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46568.1"
/translation="MIGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQ
LAAGYPADEHFKPVYNPWDQRLCAVPDADMFKAIRDGRASVVTEAIDTFTENGIRLQS
GRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVAFKGFLLSDVSNFAGPHGRT
RAHHLLSAAARSHADPAAAGRRSPLADLKVLREGPVDDDHLRFTTSASASRLTVKRIT
RSTPWN"
gene complement(4192850..4193245)
/locus_tag="Rv3742c"
CDS complement(4192850..4193245)
/codon_start=1
/transl_table=11
/locus_tag="Rv3742c"
/product="Possible oxidoreductase"
/note="Rv3742c, (MTV025.090c), len: 131 aa. Possible
oxidoreductase, probably combines with product of
downstream ORF MTV025.090c to form a functional
monooxygenase, highly similar to N-terminal end of various
oxidoreductases e.g. Q9A588|CC2569 monooxygenase
(flavin-binding family) from Caulobacter crescentus (498
aa), FASTA scores: opt: 170, E(): 0.00048, (47.55%
identity in 103 aa overlap); Q9APW3 aromatic-ring
hyroxylase from Pseudomonas aeruginosa (508 aa) FASTA
scores: opt: 160,E(): 0.0022, (50.55% identity in 87 aa
overlap); Q9RZT0|DRB0033 arylesterase/monoxygenase from
Deinococcus radiodurans (833 aa), FASTA scores: opt: 153,
E(): 0.0097,(45.45% identity in 88 aa overlap); etc. Also
similar to C-terminal end of Mycobacterium tuberculosis
proteins (generally monooxygenases) e.g.
P96223|Rv3854c|MTCY01A6.14 hypothetical 55.3 KDA protein
(489 aa), FASTA scores: opt: 140, E(): 0.044, (37.1%
identity in 132 aa overlap); O53300|Rv3083|MTV013.04
monoxygenase (495 aa) FASTA scores: opt: 133, E(): 0.13,
(43.05% identity in 79 aa overlap);
O53762|Rv0565c|MTV039.03c putative monoxygenase (486
aa),FASTA scores: opt: 110, E(): 4.1, (42.85% identity in
77 aa overlap); etc. Note similarity to MTCY01A6.14 and
MTV013.04 continue in downstream ORF (MTV025.089c) after a
gap of ~100 aa."
/db_xref="EnsemblGenomes-Gn:Rv3742c"
/db_xref="EnsemblGenomes-Tr:CCP46569"
/db_xref="GOA:O69709"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O69709"
/protein_id="CCP46569.1"
/translation="MHSEQSASIEHVDVLIVGAGISGTGAAYYLKTMQPAKTFAIVEA
RYPAIRSDSDLHTFSYEFKPWQHEKATASADAIMVHRGRSLAGGDRTLRHRRTRHHEL
RMVIIGSGATAVTLVPAMAQTAGAVTMPK"
gene complement(4193391..4195373)
/gene="ctpJ"
/gene_synonym="nmtA"
/locus_tag="Rv3743c"
CDS complement(4193391..4195373)
/codon_start=1
/transl_table=11
/gene="ctpJ"
/gene_synonym="nmtA"
/locus_tag="Rv3743c"
/product="Probable cation transporter P-type ATPase CtpJ"
/note="Rv3743c, (MTV025.091c), len: 660 aa. Probable
ctpJ,cation-transporting P-type ATPase, transmembrane
protein highly similar to others e.g. Q9ZBF3|SC9B5.27
putative cation-transporting ATPase from Streptomyces
coelicolor (638 aa), FASTA scores: opt: 1635, E():
2.5e-86, (62.25% identity in 63.95 aa overlap);
Q59997|CADA|SLR0797 cadmium-transporting ATPase from
Synechocystis sp. strain PCC 6803 (642 aa), FASTA scores:
opt: 1474, E(): 4.3e-77,(42.4% identity in 604 aa
overlap); P30336|CADA_BACFI probable cadmium-transporting
ATPase from Bacillus firmus (723 aa), FASTA scores: opt:
1327, E(): 1.3e-68, (36.6% identity in 626 aa overlap);
etc. Also highly similar to
O53160|CTPD_MYCTU|Rv1469|MT1515|MTV007.16 probable
cation-transporting P-type ATPase D from Mycobacterium
tuberculosis (657 aa), FASTA scores: opt: 1845, E():
2.3e-98, (55.85% identity in 650 aa overlap). Contains
PS00154 E1-E2 ATPases phosphorylation site and PS01229
Hypothetical family signature 2. Belongs to the cation
transport ATPases family (E1-E2 ATPases). Transcription is
repressed by NmtR (See Cavet et al., 2002)."
/db_xref="EnsemblGenomes-Gn:Rv3743c"
/db_xref="EnsemblGenomes-Tr:CCP46570"
/db_xref="GOA:P9WPT7"
/db_xref="InterPro:IPR001757"
/db_xref="InterPro:IPR008250"
/db_xref="InterPro:IPR018303"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR023298"
/db_xref="InterPro:IPR023299"
/db_xref="InterPro:IPR027256"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/Swiss-Prot:P9WPT7"
/inference="protein motif:PROSITE:PS01229"
/inference="protein motif:PROSITE:PS00154"
/protein_id="CCP46570.1"
/translation="MAVRELSPARCTSASPLVLARRTKLFALSEMRWAALALGLFSAG
LLTQLCGAPQWVRWALFLACYATGGWEPGLAGLQALQRRTLDVDLLMVVAAIGAAAIG
QIAEGALLIVIFATSGALEALVTARTADSVRGLMGLAPGTATRVGAGGGEETVNAADL
RIGDIVLVRPGERISADATVLAGGSEVDQATVTGEPLPVDKSIGDQVFAGTVNGTGAL
RIRVDRLARDSVVARIATLVEQASQTKARTQLFIEKVEQRYSIGMVAVTLAVFAVPPL
WGETLQRALLRAMTFMIVASPCAVVLATMPPLLAAIANAGRHGVLAKSAIVMEQLGTT
TRIAFDKTGTLTRGTPELAGIWVYERRFTDDELLRLAAAAEYPSEHPLGAAIVKAAQS
RRIRLPTVGEFTAHPGCRVTARVDGHVIAVGSATALLGTAGAAALEASMITAVDFLQG
EGYTVVVVVCDSHPVGLLAITDQLRPEAAAAISAATKLTGAKPVLLTGDNRATADRLG
VQVGIDDVRAGLLPDDKVAAVRQLQAGGARLTVVGDGINDAPALAAAHVGIAMGSARS
ELTLQTADAVVVRDDLTTIPTVIAMSRRARRIVVANLIVAVTFIAGLVVWDLAFTLPL
PLGVARHEGSTIIVGLNGLRLLRHTAWRRAAGTAHR"
gene 4195440..4195802
/gene="nmtR"
/locus_tag="Rv3744"
CDS 4195440..4195802
/codon_start=1
/transl_table=11
/gene="nmtR"
/locus_tag="Rv3744"
/product="Metal sensor transcriptional regulator
(ArsR-SmtB family)"
/note="Rv3744, (MTV025.092), len: 120 aa. Transcriptional
regulator nmtR (See Cavet et al., 2002). Highly similar to
many e.g. Q9ZBF4|SC9B5.26c from Streptomyces coelicolor
(120 aa), FASTA scores: opt: 480, E(): 2.4e-24, (63.25%
identity in 117 aa overlap); O31844|YOZA YOZA regulator
from Bacillus subtilis (107 aa), FASTA scores: opt:
249,E(): 1.6e-09, (44.8% identity in 96 aa overlap);
P30340|SMTB_SYNP7|SMTB from Synechococcus sp. strain PCC
7942 (Anacystis nidulans R2) (122 aa), FASTA scores: opt:
230, E(): 2.9e-08, (46.0% identity in 87 aa overlap); etc.
Equivalent to AAK48216 from Mycobacterium tuberculosis
strain CDC1551 (135 aa) but shorter 15 aa. Also similar to
MTCY27_22; MTCY39_25; and MTCY441_12. Contains
helix-turn-helix motif at aa 47-68 (Score 1815, +5.37 SD).
Belongs to the ArsR-SmtB family of transcriptional
regulators."
/db_xref="EnsemblGenomes-Gn:Rv3744"
/db_xref="EnsemblGenomes-Tr:CCP46571"
/db_xref="GOA:O69711"
/db_xref="InterPro:IPR001845"
/db_xref="InterPro:IPR011991"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="UniProtKB/Swiss-Prot:O69711"
/protein_id="CCP46571.1"
/translation="MGHGVEGRNRPSAPLDSQAAAQVASTLQALATPSRLMILTQLRN
GPLPVTDLAEAIGMEQSAVSHQLRVLRNLGLVVGDRAGRSIVYSLYDTHVAQLLDEAI
YHSEHLHLGLSDRHPSAG"
gene complement(4195886..4196098)
/locus_tag="Rv3745c"
CDS complement(4195886..4196098)
/codon_start=1
/transl_table=11
/locus_tag="Rv3745c"
/product="Conserved hypothetical protein"
/note="Rv3745c, (MTV025.093c), len: 70 aa. Conserved
hypothetical protein, highly similar to others e.g.
N-terminus of Q9X4E6 hypothetical 13.4 KDA protein from
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
(124 aa), FASTA scores: opt: 279, E(): 4.4e-14, (59.4%
identity in 69 aa overlap); N-terminus of Q9A2A6|CC3660
hypothetical protein from Caulobacter crescentus (172 aa)
FASTA scores: opt: 272, E(): 1.9e-13, (63.35% identity in
60 aa overlap); N-terminus of P74345|SLR1628 hypothetical
14.5 KDA protein from Synechocystis sp. strain PCC 6803
(134 aa), FASTA scores: opt: 233, E(): 1.3e-10, (54.85%
identity in 62 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3745c"
/db_xref="EnsemblGenomes-Tr:CCP46572"
/db_xref="InterPro:IPR018714"
/db_xref="UniProtKB/TrEMBL:O69712"
/protein_id="CCP46572.1"
/translation="MSDCNVLGGALEQGGTDPLTGFYRDGCCATGPEDLGWHTICAVM
TTEFLAHQRSVGNDLSIARPPRWLRP"
gene complement(4196171..4196506)
/gene="PE34"
/locus_tag="Rv3746c"
CDS complement(4196171..4196506)
/codon_start=1
/transl_table=11
/gene="PE34"
/locus_tag="Rv3746c"
/product="Probable PE family protein PE34 (PE
family-related protein)"
/note="Rv3746c, (MTV025.094c), len: 111 aa. PE34, Probable
member of the Mycobacterium tuberculosis PE family (see
citation below), but without the glycine-rich C-terminal
part, similar to N-termini of many e.g.
O69737|Rv3872|MTV027.07 (99 aa) FASTA scores: opt:
306,E(): 1e-13, (50.5% identity in 99 aa overlap);
O53215|Rv2490c|MTV008.46 (1660 aa) FASTA scores: opt:
125,E(): 0.99, (34.25% identity in 111 aa overlap). Also
weakly similar to MTV008_46; MTCI418B_6; MTCY130_1;
MTY25D10_11; MTCY1A11_25; MTCY21B4_13; MTCY21B4_27;
MTCY493_2; MTCY28_25; etc."
/db_xref="EnsemblGenomes-Gn:Rv3746c"
/db_xref="EnsemblGenomes-Tr:CCP46573"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:Q79FA1"
/protein_id="CCP46573.1"
/translation="MQSMSFDPAVADIGSQVVNNAFQGLQAGAVAWVSLSSLLPAGAE
EVSAWAVTAFTTAATGLLALNQAAQEELRKAGEVFTAIARMYSDADVRAAACLLEAIP
RPGQTLARE"
gene 4196724..4197107
/locus_tag="Rv3747"
CDS 4196724..4197107
/codon_start=1
/transl_table=11
/locus_tag="Rv3747"
/product="Conserved protein"
/note="Rv3747, (MTV025.095), len: 127 aa. Conserved
protein, highly similar to downstream ORF
O69715|Rv3748|MTV025.096 conserved hypothetical protein
(119 aa), FASTA scores: opt: 494, E(): 6e-27, (64.4%
identity in 118 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3747"
/db_xref="EnsemblGenomes-Tr:CCP46574"
/db_xref="UniProtKB/TrEMBL:O69714"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46574.1"
/translation="MILTGAFLADAAAAVDNKLNVQGGVLSRFAVGPDRLARFVLVVL
TQAEPDSSDRDITVEMRPPTDDEPIRLNFEAPEAAVAEFPGFAFFEIQLRLPVNGRWV
LVVTGGTGAISLPVLVSDMPATIGF"
gene 4197236..4197595
/locus_tag="Rv3748"
CDS 4197236..4197595
/codon_start=1
/transl_table=11
/locus_tag="Rv3748"
/product="Conserved hypothetical protein"
/note="Rv3748, (MTV025.096), len: 119 aa. Hypothetical
protein, highly similar to upstream ORF
O69714|Rv3747|MTV025.095 conserved hypothetical protein
(127 aa), FASTA scores: opt: 496, E(): 2.5e-28, (64.4%
identity in 118 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3748"
/db_xref="EnsemblGenomes-Tr:CCP46575"
/db_xref="UniProtKB/TrEMBL:O69715"
/protein_id="CCP46575.1"
/translation="MIVGAFLAEAASVVDNKLNVSGGVLYRFAVDPDRSAQFLLVVLT
QAETDDPDRRVDVEVWPPTGDDAHHIEFELPEAAVAAEVGFAIFRIEVNLPVDGRWVL
VVTGGAGTISLPLIVTG"
gene complement(4197628..4198137)
/locus_tag="Rv3749c"
CDS complement(4197628..4198137)
/codon_start=1
/transl_table=11
/locus_tag="Rv3749c"
/product="Conserved hypothetical protein"
/note="Rv3749c, (MTV025.097c), len: 169 aa. Hypothetical
protein, showing some similarity with O85864 hypothetical
21.4 KDA protein from Sphingomonas aromaticivorans plasmid
pNL1 (196 aa), FASTA scores: opt: 148, E(): 0.011, (32.7%
identity in 104 aa overlap); Q9LCU6 hypothetical 21.2 KDA
protein from Arthrobacter sp. TM1 (192 aa), FASTA scores:
opt: 125, E(): 0.35, (31.5% identity in 92 aa overlap);
Q9L631|SPCB myo-inositol-2-dehydrogenase from Streptomyces
spectabilis (374 aa); Q9WJP8|PRE-S1 PRE-S1 protein
(fragment) from Hepatitis B virus (88 aa); etc. Contains
PS00092 N-6 Adenine-specific DNA methylases signature.
Predicted to be an outer membrane protein (See Song et
al.,2008). This region is a possible MT-complex-specific
genomic island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3749c"
/db_xref="EnsemblGenomes-Tr:CCP46576"
/db_xref="GOA:L0TGF0"
/db_xref="UniProtKB/Swiss-Prot:L0TGF0"
/inference="protein motif:PROSITE:PS00092"
/protein_id="CCP46576.1"
/translation="MPCCGSLTRAPIGLCGRRTSWPRLGEPWSTASTSAPNGLTTAFA
FGYNDLIAAMNNHYKDRHVLAAAVRERAEVIVTTNLKHFPDDALKPYQIKALHPDDFL
LDQLDLYEEATKAVILGMVDAYIDPPFTPHSLLDALGEQVPQFAAKARRLFPSGSPFG
LGVLLPFDQ"
gene complement(4198205..4198597)
/locus_tag="Rv3750c"
CDS complement(4198205..4198597)
/codon_start=1
/transl_table=11
/locus_tag="Rv3750c"
/product="Possible excisionase"
/note="Rv3750c, (MTV025.098c), len: 130 aa. Possible
excisionase, similar to others e.g. Q9LCU5 putative
excisionase from Arthrobacter sp. TM1 (174 aa) FASTA
scores: opt: 297, E(): 1.2e-12, (40.35% identity in 114 aa
overlap); O85865 putative excisionase from Sphingomonas
aromaticivorans plasmid pNL1 (152 aa), FASTA scores: opt:
223, E(): 7.3e-08, (39.15% identity in 97 aa overlap);
Q9XBH1|xis excisionase from Bacteroides fragilis (124 aa)
FASTA scores: opt: 128, E(): 0.1, (30.7% identity in 88 aa
overlap); etc. Also some similarity to transcriptional
regulators. Also similar to Mycobacterium tuberculosis
hypothetical proteins e.g.
P71902|YN10_MYCTU|Rv2310|MT2372|MTCY3G12.24c (114 aa)
FASTA scores: opt: 224, E(): 4.9e-08, (42.7% identity in
82 aa overlap). Contains helix-turn-helix motif at aa
55-76 (Score 1925,+5.74 SD). This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3750c"
/db_xref="EnsemblGenomes-Tr:CCP46577"
/db_xref="GOA:O69717"
/db_xref="InterPro:IPR009061"
/db_xref="InterPro:IPR010093"
/db_xref="InterPro:IPR041657"
/db_xref="UniProtKB/Swiss-Prot:O69717"
/protein_id="CCP46577.1"
/translation="MTSLLEVLGAPEVSVCGNAGQPMTLPEPVRDALYNVVLALSQGK
GISLVPRHLKLTTQEAADLLNISRPTLVRLLEDGRIPFEKPGRHRRVSLDALLEYQQE
TRSNRRAALGELSRDALGELQAALAEKK"
gene 4198874..4199089
/locus_tag="Rv3751"
CDS 4198874..4199089
/codon_start=1
/transl_table=11
/locus_tag="Rv3751"
/product="Probable integrase (fragment)"
/note="Rv3751, (MTV025.099), len: 71 aa. Probable
integrase (fragment), similar to part of many e.g. Q48908
integrase (fragment) from Mycobacterium paratuberculosis
(191 aa),FASTA scores: opt: 206, E(): 5.5e-08, (57.65%
identity in 59 aa overlap); Q9ZWV7|int integrase from
Corynephage 304L (395 aa), FASTA scores: opt: 156, E():
0.00036, (45.75% identity in 59 aa overlap); Q9K722|BH3551
integrase (phage-related protein) from Bacillus halodurans
(378 aa),FASTA scores: opt: 151, E(): 0.00079, (46.15%
identity in 52 aa overlap); etc. Also similarity with
various conjugative transposons. Also similar to
Mycobacterium tuberculosis hypothetical proteins e.g.
P71903|Rv2309c|MTCY3G12.25 (151 aa), FASTA scores: opt:
193, E(): 3.8e-07, (50.85% identity in 59 aa overlap);
O53403|Rv1055|MTV017.08 (78 aa), FASTA scores: opt:
171,E(): 7.8e-06, (54.15% identity in 48 aa overlap); etc.
This region is a possible MT-complex-specific genomic
island (See Becq et al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3751"
/db_xref="EnsemblGenomes-Tr:CCP46578"
/db_xref="GOA:O69718"
/db_xref="InterPro:IPR002104"
/db_xref="InterPro:IPR011010"
/db_xref="InterPro:IPR013762"
/db_xref="UniProtKB/TrEMBL:O69718"
/protein_id="CCP46578.1"
/translation="MKRAKVQQITPHDLRHTAASLAVSAGVNVLALQRILGHKSAKVT
LDTYADLFDADLDAVAVTLGKDADQQT"
gene complement(4199131..4199217)
/gene="serX"
tRNA complement(4199131..4199217)
/gene="serX"
/product="tRNA-Ser"
/anticodon=(pos:complement(4199181..4199183),aa:Ser,
seq:cga)
/note="codon recognized: UCG; serX, tRNA-Ser, anticodon
cga, length = 87. This region is a possible
MT-complex-specific genomic island (See Becq et al.,
2007)."
gene complement(4199247..4199705)
/locus_tag="Rv3752c"
CDS complement(4199247..4199705)
/codon_start=1
/transl_table=11
/locus_tag="Rv3752c"
/product="Possible cytidine/deoxycytidylate deaminase"
/note="Rv3752c, (MTV025.100c), len: 152 aa. Probable
cytidine/deoxycytidylate deaminase, equivalent to
Q9CB32|ML2474 possible cytidine/deoxycytidylate deaminase
from Mycobacterium leprae (171 aa), FASTA scores: opt:
890,E(): 1.6e-50, (88.1% identity in 151 aa overlap). Also
highly similar to other deaminases and hypothetical
proteins e.g. Q9AK79|2SCD60.04c putative deaminase from
Streptomyces coelicolor (143 aa), FASTA scores: opt:
559,E(): 2.9e-29, (66.45% identity in 146 aa overlap);
Q9F9W7 cytosine deaminase from Bifidobacterium longum (143
aa) FASTA scores: opt: 512, E(): 3.1e-26, (54.85% identity
in 144 aa overlap); P21335|YAAJ_BACSU hypothetical 17.8
KDA protein from Bacillus subtilis (161 aa), FASTA scores:
opt: 425, E(): 1.4e-20, (47.7% identity in 151 aa
overlap); AAK74212|SP0020 cytidine/deoxycytidylate
deaminase family protein from Streptococcus pneumoniae
(155 aa), FASTA scores: opt: 401, E(): 4.7e-19, (46.25%
identity in 147 aa overlap); P30134|YFHC_ECOLI|B2559
hypothetical 20.0 KDA protein from Escherichia coli strain
K12 (178 aa), FASTA scores: opt: 397, E(): 9.5e-19, (47.0%
identity in 149 aa overlap); etc. Contains PS00903
Cytidine and deoxycytidylate deaminases zinc-binding
region signature. Belongs to the cytidine and
deoxycytidylate deaminases family."
/db_xref="EnsemblGenomes-Gn:Rv3752c"
/db_xref="EnsemblGenomes-Tr:CCP46579"
/db_xref="GOA:O69719"
/db_xref="InterPro:IPR002125"
/db_xref="InterPro:IPR016192"
/db_xref="InterPro:IPR016193"
/db_xref="InterPro:IPR028883"
/db_xref="UniProtKB/TrEMBL:O69719"
/inference="protein motif:PROSITE:PS00903"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46579.1"
/translation="MTTDEDLIRAALAVAATAGPRDVPVGAVVVGADGTELARAVNAR
EALGDPTAHAEILAMRLAAGVLGDGWRLEGTTLAVTVEPCTMCAGALVLARVARLVFG
AWEPKTGAVGSLWDVVRDRRLNHRPEVRGGVLARECAAPLEAFFARQRLG"
gene complement(4199721..4200221)
/locus_tag="Rv3753c"
CDS complement(4199721..4200221)
/codon_start=1
/transl_table=11
/locus_tag="Rv3753c"
/product="Conserved protein"
/note="Rv3753c, (MTV025.101c), len: 166 aa. Conserved
protein, only equivalent to Q9CB33|ML2473 hypothetical
protein from Mycobacterium leprae (159 aa) FASTA scores:
opt: 920 E(): 1.4e-52,, (88.6% identity in 158 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3753c"
/db_xref="EnsemblGenomes-Tr:CCP46580"
/db_xref="InterPro:IPR023869"
/db_xref="UniProtKB/TrEMBL:O69720"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46580.1"
/translation="MQRPAADTPDGFGVAVVREEGRWRCSPMGPKALTSLRAAETELR
ELRSAGAVFGLLDVDDEFFVIVRPAPSGTRLLLSDATAALDYDIAAEVLDNLDAEIDP
EDLEDADPFEEGDLGLLSDIGLPEAVLGVILDETDLYADEQLGRIAREMGFADQLSAV
IDRLGR"
gene 4200421..4201326
/gene="tyrA"
/locus_tag="Rv3754"
CDS 4200421..4201326
/codon_start=1
/transl_table=11
/gene="tyrA"
/locus_tag="Rv3754"
/product="Prephenate dehydrogenase TyrA (PDH)
(hydroxyphenylpyruvate synthase)"
/note="Rv3754, (MTV025.102), len: 301 aa. Probable
tyrA,prephenate dehydrogenase, equivalent, but shorter 27
aa, to Q9CB34|ML2472 possible prephenate dehydrogenase
from Mycobacterium leprae (327 aa) FASTA scores: opt:
1600, E(): 1.6e-89, (80.0% identity in 300 aa overlap).
Also similar to many pephenate dehydrogenases e.g.
Q9RND8|TYRA from Bordetella bronchiseptica (Alcaligenes
bronchisepticus) (299 aa), FASTA scores: opt: 345, E():
9.7e-14, (32.85% identity in 271 aa overlap);
Q9RVA7|DR1122 from Deinococcus radiodurans (372 aa) FASTA
scores: opt: 341, E(): 2e-13,(35.65% identity in 216 aa
overlap); P20692|TYRA_BACSU from Bacillus subtilis (372
aa), FASTA scores: opt: 314, E(): 8.6e-12, (27.75%
identity in 263 aa overlap); etc. Also similar to
Q04983|TYRC_ZYMMO TYRC protein [includes: cyclohexadienyl
dehydrogenase and prephenate dehydrogenase activities]
from Zymomonas mobilis (293 aa), FASTA scores: opt: 290,
E(): 2e-10, (30.15% identity in 239 aa overlap).
Equivalent to AAK48225 from Mycobacterium tuberculosis
strain CDC1551 (323 aa) but shorter 22 aa."
/db_xref="EnsemblGenomes-Gn:Rv3754"
/db_xref="EnsemblGenomes-Tr:CCP46581"
/db_xref="GOA:O69721"
/db_xref="InterPro:IPR003099"
/db_xref="InterPro:IPR008927"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:O69721"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46581.1"
/translation="MRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAA
TEALIVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHP
MTGTAHSGWTAGHGGLFNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHD
AAAAAVSHLPHLLAEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTG
QLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGADKW
REQLAAAGRAGGVITSALPSLDSPQ"
gene complement(4201289..4201888)
/locus_tag="Rv3755c"
CDS complement(4201289..4201888)
/codon_start=1
/transl_table=11
/locus_tag="Rv3755c"
/product="Conserved protein"
/note="Rv3755c, (MTV025.103c), len: 199 aa. Conserved
protein showing similarity to CAC47343|SMC03980 conserved
hypothetical protein from Rhizobium meliloti
(Sinorhizobium meliloti) (196 aa) FASTA scores: opt: 244,
E(): 4.1e-09,(30.9% identity in 191 aa overlap);
Q9I2B5|PA1994 from Pseudomonas aeruginosa (187 aa), FASTA
scores: opt: 226,E(): 6e-08, (29.9% identity in 194 aa
overlap); and Q98N73|MLR0268 hypothetical protein (183
aa), FASTA scores: opt: 234, E(): 1.8e-08, (27.05%
identity in 185 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3755c"
/db_xref="EnsemblGenomes-Tr:CCP46582"
/db_xref="InterPro:IPR009467"
/db_xref="UniProtKB/TrEMBL:O86358"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46582.1"
/translation="MNAVPSDLTPRVWPAMLTWRAQDISRMESVRVQLSGKRIRANGR
IVAAATANNPAFGAHYDLQTDETGATKRFGLTVTLAERERQLAIARDEENMWLVTDHQ
GERRAAYNGALDIDLVFSPFFNALPIRRLGLHERAESIALPVVYVNVPEMSVDAATVS
YTSEGRLDGIKLRSPVADTTVTVDSDGFIVDYPGLAERM"
gene complement(4201894..4202613)
/gene="proZ"
/locus_tag="Rv3756c"
CDS complement(4201894..4202613)
/codon_start=1
/transl_table=11
/gene="proZ"
/locus_tag="Rv3756c"
/product="Possible osmoprotectant (glycine
betaine/carnitine/choline/L-proline) transport integral
membrane protein ABC transporter ProZ"
/note="Rv3756c, (MTV025.104c), len: 239 aa. Possible
proZ,osmoprotectant transport integral membrane protein
ABC transporter (see citation below), similar to
osmoprotection proteins (proW, proZ) involved in glycine
betaine/L-proline/choline transport, e.g.
BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB protein
(probable glycine betaine/carnitine/choline ABC
transporter) from Staphylococcus aureus (211 aa) FASTA
scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa
overlap); Q45461|OPBB_BACSU|OPUBB|prow choline transport
system permease protein (mediate the uptake of choline for
synthesis of the osmoprotectant glycine betaine) from
Bacillus subtilis (217 aa), FASTA scores: opt: 402, E():
1.9e-16, (32.0% identity in 203 aa overlap);
O34878|OPCB_BACSU|OPUCB glycine betaine/carnitine/choline
transport system permease protein from Bacillus subtilis
(217 aa), FASTA scores: opt: 385, E(): 1.8e-15, (30.2%
identity in 222 aa overlap);
P39775|O34657|OPUBD|PROZ|OPBD_BACSU choline transport
system permease protein from Bacillus subtilis (226 aa)
FASTA scores: opt: 350, E(): 2e-13, (31.75% identity in
208 aa overlap); etc. Could belong to the CYSTW
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3756c"
/db_xref="EnsemblGenomes-Tr:CCP46583"
/db_xref="GOA:O69722"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:O69722"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46583.1"
/translation="MNFLQQALSYLLTASNWTGPVGLAVRTCEHLEYTAVAVAASALI
AVPVGLLIGHTGRGTLLVVGAVNGLRALPTLGVLLLGVLLFGLGLGPPLVALMLLGIP
SLLASTYAGIASVDPLVVDAARAMGMTESQVLLRVEVPNALPLMLGGLRSATLQVVAT
ATVAAYASLGGLGGYLIDGIKERRFHIALVGAMMVAALALTLDGLLALAGWVSVPGTG
RMRKLAAVVDKPAAGGGHALR"
gene complement(4202610..4203299)
/gene="proW"
/locus_tag="Rv3757c"
CDS complement(4202610..4203299)
/codon_start=1
/transl_table=11
/gene="proW"
/locus_tag="Rv3757c"
/product="Possible osmoprotectant (glycine
betaine/carnitine/choline/L-proline) transport integral
membrane protein ABC transporter ProW"
/note="Rv3757c, (MTV025.105c), len: 229 aa. Possible
proW,osmoprotectant transport integral membrane protein
ABC transporter (see citation below), similar to
osmoprotection proteins (proW, proZ) involved in glycine
betaine/L-proline/choline transport, e.g.
BAB58607|Q99RI6|OPUCD|SA2234|SAV2445 OPUCD protein
(probable glycine betaine/carnitine/choline ABC
transporter) from Staphylococcus aureus (231 aa) FASTA
scores: opt: 364, E(): 7.1e-15, (30.0% identity in 220 aa
overlap); Q45461|OPBB_BACSU|OPUBB|prow choline transport
system permease protein (mediate the uptake of choline for
synthesis of the osmoprotectant glycine betaine) from
Bacillus subtilis (217 aa), FASTA scores: opt: 348, E():
6.2e-14, (31.05% identity in 206 aa overlap);
O34878|OPCB_BACSU|OPUCB glycine betaine/carnitine/choline
transport system permease protein from Bacillus subtilis
(217 aa), FASTA scores: opt: 343, E(): 1.2e-13, (30.1%
identity in 206 aa overlap); O34742|OPCD_BACSU|OPUCD
glycine betaine/carnitine/choline transport system
permease protein from Bacillus subtilis (229 aa) FASTA
scores: opt: 337, E(): 2.9e-13, (31.1% identity in 193 aa
overlap); etc. Could belong to the CYSTW subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3757c"
/db_xref="EnsemblGenomes-Tr:CCP46584"
/db_xref="GOA:O69723"
/db_xref="InterPro:IPR000515"
/db_xref="InterPro:IPR035906"
/db_xref="UniProtKB/TrEMBL:O69723"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46584.1"
/translation="MHYLMTHPGAAWALTVVHLRLSLLPVLIGLMSAVPLGLLVQRAP
LLRRLTTATASVIFTIPSLALFVVLPLIIGTRILDEANVIVALAAYTTALLVRAVLEA
LDAVPAQVHDAATAIGYSRIAQMLKVELPLSIPVLVAGLRVVAVTNIAMVSVGSVIGI
GGLGTWFTAGYQTNKSDQIVAGVVAMFLLAIVVDVVINLAGRLATPWERAPRAARRRR
QVAAPITGGAR"
gene complement(4203287..4204417)
/gene="proV"
/locus_tag="Rv3758c"
CDS complement(4203287..4204417)
/codon_start=1
/transl_table=11
/gene="proV"
/locus_tag="Rv3758c"
/product="Possible osmoprotectant (glycine
betaine/carnitine/choline/L-proline) transport ATP-binding
protein ABC transporter ProV"
/note="Rv3758c, (MTV025.106c), len: 376 aa. Possible
proV,osmoprotectant transport ATP-binding protein ABC
transporter (see citation below), highly similar to
osmoprotection proteins (proV) involved in glycine
betaine/L-proline/choline transport, e.g.
BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 glycine
betaine/carnitine/choline ABC transporter (ATP-binding)
from Staphylococcus aureus (410 aa), FASTA scores: opt:
816, E(): 8.4e-39, (39.5% identity in 362 aa overlap);
O34992|OPCA_BACSU|OPUCA glycine betaine/carnitine/choline
transport ATP-binding protein from Bacillus subtilis (380
aa), FASTA scores: opt: 807, E(): 2.5e-38, (40.55%
identity in 333 aa overlap); Q45460|OPBA_BACSU|OPUBA|prov
choline transport ATP-binding protein from Bacillus
subtilis (381 aa), FASTA scores: opt: 801, E(): 5.6e-38,
(40.65% identity in 337 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop) and PS00211 ABC
transporter family signature. Belongs to the ATP-binding
transport protein family (ABC transporters)."
/db_xref="EnsemblGenomes-Gn:Rv3758c"
/db_xref="EnsemblGenomes-Tr:CCP46585"
/db_xref="GOA:O69724"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O69724"
/inference="protein motif:PROSITE:PS00211"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46585.1"
/translation="MICFDDVSKVYAHGATAVDRLTLEVPNGMLTVFVGPSGCGKTTA
LRMINRMVDPTSGTITVDGTDVSTVNAVKLRLGIGYVIQNAGLMPHQRVIDNVATVPV
LKGQPRRAARKAGYEVLERVGLDPKVATRYPAQLSGGEQQRVGVARALAADPPILLMD
EPFSAVDPVVRHELQNEILRLQAELHKTIVFVTHDIDEALKLADLVAVFAPGGALAQY
DETARLLSSPANDFVSKFIGLGRGYRWLQLFDAAGLPVRDIEQVSVNGLSDARDRQVR
DGWVLVVDGAGAPLGWIDADGRRRHRGGAALSDAMTVGGSVFRPNGNLSQALDAALSS
PSGVGVAVDGGGKVIGGILAADVLAEFQKGKKAGGGAKPCTT"
gene complement(4204426..4205373)
/gene="proX"
/locus_tag="Rv3759c"
CDS complement(4204426..4205373)
/codon_start=1
/transl_table=11
/gene="proX"
/locus_tag="Rv3759c"
/product="Possible osmoprotectant (glycine
betaine/carnitine/choline/L-proline) binding lipoprotein
ProX"
/note="Rv3759c, (MTV025.107c), len: 315 aa. Possible
proX,osmoprotectant-binding lipoprotein component of
osmoprotectant transport system (see citation
below),similar to osmoprotection proteins (proX) involved
in glycine betaine/L-proline/choline transport, e.g.
AAK79442|CAC1474 proline/glycine betaine ABC transport
system periplasmic component from Clostridium
acetobutylicum (303 aa), FASTA scores: opt: 308, E():
1.2e-11, (27.4% identity in 314 aa overlap);
Q9X4J2|PROXL|SCE19A.33 PROXL protein from Streptomyces
coelicolor (322 aa), FASTA scores: opt: 302, E():
3e-11,(27.2% identity in 327 aa overlap); O29280|AF0982
osmoprotection protein (PROX) from Archaeoglobus fulgidus
(292 aa), FASTA scores: opt: 235, E(): 3.4e-07, (23.15%
identity in 285 aa overlap); etc. Also similar to
MTV006_16 hypothetical protein from Mycobacterium
tuberculosis, and MLU15180_43 hypothetical protein from
Mycobacterium leprae. Equivalent to AAK48230 from
Mycobacterium tuberculosis strain CDC1551 (343 aa) but
shorter 28 aa. Contains probable N-terminal signal
sequence."
/db_xref="EnsemblGenomes-Gn:Rv3759c"
/db_xref="EnsemblGenomes-Tr:CCP46586"
/db_xref="GOA:O69725"
/db_xref="InterPro:IPR007210"
/db_xref="UniProtKB/TrEMBL:O69725"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46586.1"
/translation="MRMLRRLRRATVAAAVWLATVCLVASCANADPLGSATGSVKSIV
VGSGDFPESQVIAEIYAQVLQANGFDVGRRLGIGSRETYILALKDHSIDLVPEYIGNL
LLYFQPDATVTMLDAVELELYKRLPGDLSILTPSPASDTDTVTVTAATAARWNLKTIA
DLAPHSADVKFAAPSAFQTRPSGLPGLRHKYSLDIAPGNFVTINDGGGAVTVRALVEG
TATAANLFSTSAAIPQNHLVVLEDPEHNFLAGNIVPLVNSRKKSDHLKDVLDAVSAKL
TTAGLAELNAAVSGNSGVDPDQAARKWVRDNGFDHPVRQ"
gene 4205538..4205840
/locus_tag="Rv3760"
CDS 4205538..4205840
/codon_start=1
/transl_table=11
/locus_tag="Rv3760"
/product="Possible conserved membrane protein"
/note="Rv3760, (MTV025.108), len: 100 aa. Possible
conserved membrane protein, equivalent to
Q50094|ML2366|MLCB12.11c putative membrane protein from
Mycobacterium leprae (113 aa), FASTA scores: opt: 423,
E(): 1.2e-20, (67.7% identity in 99 aa overlap). Also
similar with Q9JST1|NMA2149 putative inner membrane
hypothetical protein from Neisseria meningitidis
(serogroup A) (104 aa),FASTA scores: opt: 113, E(): 0.95,
(33.85% identity in 62 aa overlap); and showing similarity
with Q9ZAX7 ABC transporter membrane protein subunit from
Streptococcus mutans (498 aa), FASTA scores: opt: 108,
E(): 6.7, (42.35% identity in 85 aa overlap) (similarity
at C-terminus); and P33108|SECY_MICLU preprotein
translocase SECY subunit from Micrococcus luteus
(Micrococcus lysodeikticus) (436 aa),FASTA scores: opt:
106, E(): 8.2, (29.05% identity in 86 aa overlap).
Equivalent to AAK48231 from Mycobacterium tuberculosis
strain CDC1551 (117 aa) but shorter 17 aa."
/db_xref="EnsemblGenomes-Gn:Rv3760"
/db_xref="EnsemblGenomes-Tr:CCP46587"
/db_xref="GOA:O69726"
/db_xref="InterPro:IPR010445"
/db_xref="UniProtKB/Swiss-Prot:O69726"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46587.1"
/translation="MPGSVPGKAPEEPPVKFTRAAAVWSALIVGFLILILLLIFIAQN
TASAQFAFFGWRWSLPLGVAILLAAVGGGLITVFAGTARILQLRRAAKKTHAAALR"
gene complement(4205862..4206917)
/gene="fadE36"
/locus_tag="Rv3761c"
CDS complement(4205862..4206917)
/codon_start=1
/transl_table=11
/gene="fadE36"
/locus_tag="Rv3761c"
/product="Possible acyl-CoA dehydrogenase FadE36"
/note="Rv3761c, (MTV025.109c), len: 351 aa. Possible
fadE36, acyl-CoA dehydrogenase, similar to many conserved
hypothetical proteins and showing some similarity with few
acyl-CoA dehydrogenases, e.g. Q9APX7|FADE36 FADE36 protein
from Pseudomonas aeruginosa (360 aa), FASTA scores: opt:
147, E(): 0.046, (26.15% identity in 214 aa overlap); part
of AAB52261.2|U97002 protein similar to acyl-CoA
dehydrogenases and epoxide hydrolases from Caenorhabditis
elegans (985 aa), FASTA score: (31.2% identity in 324 aa
overlap). C-terminal part is highly similar to
Q50095|U1740AK|MLU15183_45 hypothetical protein from
Mycobacterium leprae cosmid B174 (122 aa), FASTA scores:
opt: 341, E(): 7.3e-15, (57.6% identity in 99 aa overlap).
Contains PS00339 Aminoacyl-transfer RNA synthetases
class-II signature 2."
/db_xref="EnsemblGenomes-Gn:Rv3761c"
/db_xref="EnsemblGenomes-Tr:CCP46588"
/db_xref="GOA:O69727"
/db_xref="InterPro:IPR002575"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR041726"
/db_xref="UniProtKB/TrEMBL:O69727"
/inference="protein motif:PROSITE:PS00339"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46588.1"
/translation="MTSVDRLDGLDLGALDRYLRSLGIGRDGELRGELISGGRSNLTF
RVYDDASSWLVRRPPLHGLTPSAHDMAREYRVVAALGDTPVPVARTISLCQDDSVLGA
PFQVVEFVAGQVVRRRAELEALGSRSVIEGCVDALIRVLVDLHSIDPKAVGLSDFGKP
DGYLERQVRRWGSQWELVRLPDDHRDADISRLHLALQQAIPQQSRTSIVHGDYRIDNT
ILDTDDPCHVRAVVDWELSTLGDPLSDAALMCVYRDPALDLIVHAQAAWTSPLLPAAD
ELADRYSLVSGQPLGHWEFYMALAYFKLAIIAAGIDYRRRMSEQAEGKDTAAESVPDV
VAPLIARGLAEIAKKSG"
gene complement(4206996..4208876)
/locus_tag="Rv3762c"
CDS complement(4206996..4208876)
/codon_start=1
/transl_table=11
/locus_tag="Rv3762c"
/product="Possible hydrolase"
/note="Rv3762c, (MTV025.110c), len: 626 aa. Possible
hydrolase, highly similar to hypothetical proteins and
beta-lactamases e.g. Q9RL04|SC5G9.23 hypothetical 70.3 KDA
protein from Streptomyces coelicolor (648 aa), FASTA
scores: opt: 2088, E(): 3.7e-124, (52.9% identity in 624
aa overlap); P32717|YJCS_ECOLI|B4083 hypothetical 73.2 KDA
protein from Escherichia coli strain K12 (661 aa), FASTA
scores: opt: 1911, E(): 5.7e-113, (46.9% identity in 631
aa overlap); Q9A824|CC1540 metallo-beta-lactamase family
protein from Caulobacter crescentus (647 aa), FASTA
scores: opt: 1891, E(): 1e-111, (48.55% identity in 628 aa
overlap); Q08347|YOL164W chromosome xv reading frame ORF
from Saccharomyces cerevisiae (Baker's yeast) (646 aa)
FASTA scores: opt: 1829, E(): 8.4e-108, (45.7% identity in
615 aa overlap); Q9I5I9|PA0740 probable beta-lactamase
from Pseudomonas aeruginosa (658 aa), FASTA scores: opt:
1699,E(): 1.4e-99, (43.15% identity in 630 aa overlap);
Q52556|SDSA alkyl sulfatase (protein involved in the
degradation of sulfate esters of long-chain primaryal
cohols e.g. SDS sodium dodecyl sulfate) from Pseudomonas
sp (528 aa), FASTA scores: opt: 841, E(): 1.7e-45, (33.7%
identity in 534 aa overlap); etc. N-terminual end also
highly similar to Q48790|SEPA SEPA protein (protein
implicated in cell separation) from Listeria monocytogenes
(391 aa), FASTA scores: opt: 1256, E(): 8.3e-72, (49.6%
identity in 363 aa overlap). Also slight similarity to
P96253|Rv0407|MTCY22G10.03 hypothetical 37.0 KDA protein
from Mycobacterium tuberculosis (336 aa)."
/db_xref="EnsemblGenomes-Gn:Rv3762c"
/db_xref="EnsemblGenomes-Tr:CCP46589"
/db_xref="GOA:O69728"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR029228"
/db_xref="InterPro:IPR029229"
/db_xref="InterPro:IPR036527"
/db_xref="InterPro:IPR036866"
/db_xref="InterPro:IPR038536"
/db_xref="UniProtKB/TrEMBL:O69728"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46589.1"
/translation="MPMEHKPPTAVIQAAHGEHSLPLHDTTDFDDADRGFIAALSPCV
IKAADGRVVWDNDAYSFLDGAAPTSVHPSLWRQSQLTAKQGLYQVVPGIYQVRGFDIS
NISFVEGDTGLIVIDPLVSTEVAAAALDLYRAHRGADRPVVAVIYTHSHVDHFGGVLG
VTTQADVDAGKVAVLAPEGFTAHAVQENIYAGSAMMRRAGYMYGTVLARGLRGHVGCG
LGQTLSTGEVSLVVPTVDITETGETHTIDGVEIEFQMAPGTEAPAEMHFYFPRFRALC
MAENATHNLHNLLTLRGALVRDPRAWSGYLTEAIDTFADRTDVVFASHHWPTWGREKI
VEFLSQQRDMYSYLHDQTLRLLNQGYTGVEIAEMFQLPPALQRAWHTHGYYGSVSHNV
KAIYQRYMGWFDGNPGWLWPHPPEALAPRYVDALGGIDRVLELAREAFDAGDFRWAAT
LLDHAVFADSEHAAARGLYADTLEQLAYGAECATWRNFFLTGAAELRDGNPGSSGQVP
APTFFAQLTPDQIFDVLAISINGPRAWDLDLAIDFTFTEPDVNYRLTLRNGVLIHRKL
PADPATANATVTVGDKVRLVAAALGDISSPGFEVFGDRTVLQTFLSVLDRPDSAFNIV
TP"
gene 4209047..4209526
/gene="lpqH"
/locus_tag="Rv3763"
CDS 4209047..4209526
/codon_start=1
/transl_table=11
/gene="lpqH"
/locus_tag="Rv3763"
/product="19 kDa lipoprotein antigen precursor LpqH"
/note="Rv3763, (MTV025.111), len: 159 aa. LpqH, conserved
19 KDa lipoprotein antigen precursor (see citations
below),equivalent to P31502|19KD_MYCIT|MI22 19 KDA
lipoprotein antigen precursor (MI22 antigen) from
Mycobacterium intracellulare (162 aa), FASTA scores: opt:
773, E(): 6.2e-35, 75.95(% identity in 162 aa overlap);
P46733|19KD_MYCAV 19 KDA lipoprotein antigen precursor
from Mycobacterium avium (161 aa), FASTA scores: opt: 743,
E(): 2.5e-33, (72.5% identity in 160 aa overlap); and
Q9X7A5|LPQH|ML1966 possible lipoprotein from Mycobacterium
leprae FASTA scores: opt: 371, E(): 2.2e-13, (42.6%
identity in 162 aa overlap). Possibly attached to the
membrane by a lipid anchor. Similar to other mycobacterium
19 KDA antigen. Contains PS00013 Prokaryotic membrane
lipoprotein lipid attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3763"
/db_xref="EnsemblGenomes-Tr:CCP46590"
/db_xref="GOA:P9WK61"
/db_xref="InterPro:IPR008691"
/db_xref="PDB:4ZJM"
/db_xref="UniProtKB/Swiss-Prot:P9WK61"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46590.1"
/translation="MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASP
GAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGL
GNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS"
gene complement(4209582..4211009)
/gene="tcrY"
/locus_tag="Rv3764c"
CDS complement(4209582..4211009)
/codon_start=1
/transl_table=11
/gene="tcrY"
/locus_tag="Rv3764c"
/product="Possible two component sensor kinase TcrY"
/note="Rv3764c, (MTV025.112c), len: 475 aa. Possible
tcrY,histidine protein kinase, part of a two-component
regulatory system, similar to others e.g.
Q9ADN6|2SC10A7.25 putative two component system histidine
kinase from Streptomyces coelicolor (524 aa), FASTA
scores: opt: 1332,E(): 5.4e-70, (49.9% identity in 477 aa
overlap); Q9L3C1|KB|CAC42479 putative histidine kinase
from Amycolatopsis mediterranei (469 aa), FASTA scores:
opt: 515, E(): 1.4e-22, (36.1% identity in 313 aa
overlap); P72560 histidine protein kinase from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(438 aa), FASTA scores: opt: 480, E(): 1.4e-20, (40.1%
identity in 232 aa overlap);
P30847|P76401|BAES_ECOLI|B2078 sensor protein from
Escherichia coli strain K12 (467 aa); etc. Also similar to
others from Mycobacterium tuberculosis e.g.
P96368|Rv1032c|MTCY10G2.17 (509 aa), FASTA scores: opt:
1007, E(): 4e-51, (43.5% identity in 416 aa overlap); and
P71815|Rv0758|MTCY369.03 (485 aa), FASTA scores: opt:
738,E(): 1.6e-35, (28.6% identity in 438 aa overlap).
Equivalent to AAK48235 from Mycobacterium tuberculosis
strain CDC1551 (506 aa) but shorter 31 aa."
/db_xref="EnsemblGenomes-Gn:Rv3764c"
/db_xref="EnsemblGenomes-Tr:CCP46591"
/db_xref="GOA:O69729"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:O69729"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46591.1"
/translation="MGITAATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWR
HETHNYIRSGPGPRFLDAPGQPAGMVAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQL
ERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVT
VIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPSTE
VGQLGSALNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTELTQRIG
DDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGPVDMSRLAVDAVSDAH
VAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHV
VLQVIDNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTITVS
SSPGYTEFAVRLPLDGWQPLESSPR"
gene complement(4211080..4211784)
/gene="tcrX"
/locus_tag="Rv3765c"
CDS complement(4211080..4211784)
/codon_start=1
/transl_table=11
/gene="tcrX"
/locus_tag="Rv3765c"
/product="Probable two component transcriptional
regulatory protein TcrX"
/note="Rv3765c, (MTV025.113c), len: 234 aa. Probable
tcrX,response regulator of a two-component regulatory
system,highly similar to others e.g. Q9ADN7|2SC10A7.24
putative two component system response regulator from
Streptomyces coelicolor (271 aa), FASTA scores: opt: 1111,
E(): 4.8e-63,(72.3% identity in 231 aa overlap); Q9F161
response regulator from Corynebacterium glutamicum
(Brevibacterium flavum) (232 aa), FASTA scores: opt: 692,
E(): 1.2e-36,(46.0% identity in 226 aa overlap);
Q9KZU5|SCD84.23c putative two-component systen response
regulator from Streptomyces coelicolor (248 aa), FASTA
scores: opt: 674,E(): 1.7e-35, (44.05% identity in 236 aa
overlap); etc. Also highly similar to others from
Mycobacterium tuberculosis e.g. Q50806|Rv1033c|MTCY10G2.16
response regulator homolog (257 aa), FASTA scores: opt:
947, E(): 1e-52, (59.5% identity in 232 aa overlap);
P71814|Rv0757|MTCY369.02 PHOP-like protein (247 aa) FASTA
scores: opt: 829, E(): 2.8e-45, (54.65% identity in 225 aa
overlap); O53894|Rv0981|MTV044.09 (230 aa), FASTA scores:
opt: 662, E(): 9e-35, (44.65% identity in 224 aa overlap);
and also similar to MTCY31_34; MTCY19H5_20; MTY13628_5;
MTCY20G9_17; and to MLCB57_27 from Mycobacterium leprae;
and MBY13627_3 from Mycobacterium bovis BCG. Equivalent to
AAK48236 from Mycobacterium tuberculosis strain CDC1551
(286 aa) but shorter 52 aa. The N-terminal region is
similar to that of other regulatory components of sensory
transduction systems. Similar to bacterial regulatory
proteins involved in signal transduction."
/db_xref="EnsemblGenomes-Gn:Rv3765c"
/db_xref="EnsemblGenomes-Tr:CCP46592"
/db_xref="GOA:O69730"
/db_xref="InterPro:IPR001789"
/db_xref="InterPro:IPR001867"
/db_xref="InterPro:IPR011006"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039420"
/db_xref="UniProtKB/Swiss-Prot:O69730"
/protein_id="CCP46592.1"
/translation="MRRADGQPVTVLVVDDEPVLAEMVSMALRYEGWNITTAGDGSSA
IAAARRQRPDVVVLDVMLPDMSGLDVLHKLRSENPGLPVLLLTAKDAVEDRIAGLTAG
GDDYVTKPFSIEEVVLRLRALLRRTGVTTVDSGAQLVVGDLVLDEDSHEVMRAGEPVS
LTSTEFELLRFMMHNSKRVLSKAQILDRVWSYDFGGRSNIVELYISYLRKKIDNGREP
MIHTLRGAGYVLKPAR"
gene 4212293..4212982
/locus_tag="Rv3766"
CDS 4212293..4212982
/codon_start=1
/transl_table=11
/locus_tag="Rv3766"
/product="Hypothetical protein"
/note="Rv3766, (MTV025.114), len: 229 aa. Hypothetical
unknown protein. Segment 183 to 229 highly similar to
C-terminal part of O06288|Rv3594|MTCY07H7B.28c conserved
hypothetical protein from Mycobacterium tuberculosis (275
aa), FASTA scores: opt: 128, E(): 0.92, (46.8% identity in
47 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3766"
/db_xref="EnsemblGenomes-Tr:CCP46593"
/db_xref="InterPro:IPR017853"
/db_xref="UniProtKB/Swiss-Prot:O69731"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46593.1"
/translation="MRSAFDSGRLTFGIVYTYARPNWWANANTVRSMIDAAGGLHPRV
ALMLDVESGGNPPGDGSSWINRLYWNLADYAGSPVRIIGYANAYDFFNMWRVRPAGLR
VIGAGYGSNPNLPGQVAHQYTDGSGYSPNLPQGAPPFGRCDMNSANGLTPQQFAAACG
VTTTGGPLMALTDEEQTELLTKVREIWDQLRGPNGAGWPQLGQNEQGQDLTPVDAIAV
IKNDVAAMLAE"
gene complement(4212996..4213940)
/locus_tag="Rv3767c"
CDS complement(4212996..4213940)
/codon_start=1
/transl_table=11
/locus_tag="Rv3767c"
/product="Possible S-adenosylmethionine-dependent
methyltransferase"
/note="Rv3767c, (MTV025.115c, MTCY13D12.01), len: 314 aa.
Possible S-adenosylmethionine-dependent methyltransferase
(see Grana et al., 2007), similar to other Mycobacterium
tuberculosis hypothetical proteins e.g.
P96823|Rv0146|MTCI5.20 34.0 KDA protein (310 aa), FASTA
scores: opt: 909, E(): 5.3e-50, (48.1% identity in 316 aa
overlap); O53686|Rv0281|MTV035.09 (302 aa), FASTA scores:
opt: 802, E(): 2.8e-43, (45.2% identity in 314 aa
overlap); Q50726|YX99_MYCTU|Rv3399|MT3507|MTCY78.29c (348
aa), FASTA scores: opt: 796, E(): 7.6e-43, (45.35%
identity in 302 aa overlap); MTCY78_30; MTCY31_23;
MTCY210_45; MTCY4C12_14; MTY13D12_21, MTCI5_19;
MTCY180_22; etc. Contains probable N-terminal signal
sequence"
/db_xref="EnsemblGenomes-Gn:Rv3767c"
/db_xref="EnsemblGenomes-Tr:CCP46594"
/db_xref="GOA:P9WFH5"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFH5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46594.1"
/translation="MPRTDNDSWAITESVGATALGVAAARAAETESDNPLINDPFARI
FVDAAGDGIWSMYTNRTLLAGATDLDPDLRAPIQQMIDFMAARTAFFDEYFLATADAG
VRQVVILASGLDSRAWRLPWPDGTVVYELDQPKVLEFKSATLRQHGAQPASQLVNVPI
DLRQDWPKALQKAGFDPSKPCAWLAEGLVRYLPARAQDLLFERIDALSRPGSWLASNV
PGAGFLDPERMRRQRADMRRMRAAAAKLVETEISDVDDLWYAEQRTAVAEWLRERGWD
VSTATLPELLARYGRSIPHSGEDSIPPNLFVSAQRATS"
gene 4214070..4214429
/locus_tag="Rv3768"
CDS 4214070..4214429
/codon_start=1
/transl_table=11
/locus_tag="Rv3768"
/product="Unknown protein"
/note="Rv3768, (MTCY13D12.02), len: 119 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv3768"
/db_xref="EnsemblGenomes-Tr:CCP46595"
/db_xref="InterPro:IPR032710"
/db_xref="InterPro:IPR037401"
/db_xref="UniProtKB/TrEMBL:P72035"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46595.1"
/translation="MGSTPPRTPQEVFAHHGQALAAGDLDEIVADYADDSFVITPAGI
ARGKEGIRQLFVKLLDDIPNALWDLKTQIFEGDILFLEWTANSAVSRVDDGVDTFVFR
DGTIWAHTVRYTPHPKT"
gene 4214615..4214887
/locus_tag="Rv3769"
CDS 4214615..4214887
/codon_start=1
/transl_table=11
/locus_tag="Rv3769"
/product="Hypothetical protein"
/note="Rv3769, (MTCY13D12.03), len: 90 aa. Hypothetical
unknown protein, possible coiled-coil protein."
/db_xref="EnsemblGenomes-Gn:Rv3769"
/db_xref="EnsemblGenomes-Tr:CCP46596"
/db_xref="UniProtKB/TrEMBL:P72036"
/protein_id="CCP46596.1"
/translation="MTTLKELGARVAALEANQADYRAVLAAVNPPGANQREIATTVRE
HTGRLDRVTTKVGQLAAKSDDTNARVRSLEEGQAEIKDLLLRALDK"
gene complement(4215200..4215775)
/locus_tag="Rv3770c"
CDS complement(4215200..4215775)
/codon_start=1
/transl_table=11
/locus_tag="Rv3770c"
/product="Hypothetical leucine rich protein"
/note="Rv3770c, (MTCY13D12.04c), len: 191 aa. Hypothetical
unknown leu-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv3770c"
/db_xref="EnsemblGenomes-Tr:CCP46597"
/db_xref="GOA:P72037"
/db_xref="UniProtKB/TrEMBL:P72037"
/protein_id="CCP46597.1"
/translation="MLSGIQQNTLMDNDPLAHGYYVADLLVALAVVVLMLRARRTRPE
LARMLLLGTLIGLVWELPVFGLSAWTNTPIIEWATPLPLPTVVFLLAHSVWDGPLLTM
GWLLARALTGEPAGALGLTVQVLWGQLTALAVELSAILAGTWSYVDDLWFNPVMFWFR
GHPVTAAMQLTWLLAPLCFAALVRRLALTAR"
gene complement(4215881..4216063)
/locus_tag="Rv3770A"
CDS complement(4215881..4216063)
/codon_start=1
/transl_table=11
/locus_tag="Rv3770A"
/product="Probable remnant of a transposase"
/note="Rv3770A, len: 60 aa. Probable remnant of a
transposase, similar to many e.g.
Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase
from Mycobacterium tuberculosis (469 aa), FASTA scores:
opt: 204, E(): 1e-07, (80.5% identity in 41 aa overlap).
Continuation of Rv3770B."
/db_xref="EnsemblGenomes-Gn:Rv3770A"
/db_xref="EnsemblGenomes-Tr:CCP46598"
/db_xref="UniProtKB/TrEMBL:L7N6A0"
/protein_id="CCP46598.1"
/translation="MGSTPWCPNPCQCTLRTPVEVLELAVALRPENPDRTAGAIQRIL
RAQLAGDRIALRGRGS"
gene complement(4216078..4216269)
/locus_tag="Rv3770B"
CDS complement(4216078..4216269)
/codon_start=1
/transl_table=11
/locus_tag="Rv3770B"
/product="Probable remnant of a transposase"
/note="Rv3770B, len: 63 aa. Probable remnant of a
transposase, similar to many e.g.
Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase
from Mycobacterium tuberculosis (469 aa), FASTA scores:
opt: 379, E(): 1.6e-21, (93.55% identity in 62 aa
overlap). Continues as Rv3770A."
/db_xref="EnsemblGenomes-Gn:Rv3770B"
/db_xref="EnsemblGenomes-Tr:CCP46599"
/db_xref="UniProtKB/TrEMBL:L7N679"
/protein_id="CCP46599.1"
/translation="MRAERARAIGLFRYQLIREAADAAHSTKERGKMVRELASREHTD
PFGRKVRISRHTIDRWIRN"
gene complement(4216404..4216730)
/locus_tag="Rv3771c"
CDS complement(4216404..4216730)
/codon_start=1
/transl_table=11
/locus_tag="Rv3771c"
/product="Conserved hypothetical protein"
/note="Rv3771c, (MTCY13D12.05c), len: 108 aa. Hypothetical
protein, highly similar, but shorter 81 aa, to
P71640|Rv2811|MTCY16B7.32c hypothetical 21.1 KDA protein
from Mycobacterium tuberculosis (202 aa), FASTA scores:
opt: 469, E(): 2.7e-25, (73.15% identity in 108 aa
overlap)"
/db_xref="EnsemblGenomes-Gn:Rv3771c"
/db_xref="EnsemblGenomes-Tr:CCP46600"
/db_xref="GOA:P72038"
/db_xref="UniProtKB/TrEMBL:P72038"
/protein_id="CCP46600.1"
/translation="MPAPAEKALSQVGFRRIAADLARPAETVRGWLRRFAERAEAVRS
VFTVMLRAVDPDPVMPDAAVGVFAYAVTVIAAVVTVIECQFALSTVSLAETAVAVSGG
RLVAPG"
gene complement(4216865..4216937)
/gene="argU"
tRNA complement(4216865..4216937)
/gene="argU"
/product="tRNA-Arg"
/anticodon=(pos:complement(4216902..4216904),aa:Arg,
seq:acg)
/note="codon recognized: CGU; argU, tRNA-Arg, anticodon
acg, length = 73"
gene complement(4216968..4217056)
/gene="serT"
tRNA complement(4216968..4217056)
/gene="serT"
/product="tRNA-Ser"
/anticodon=(pos:complement(4217020..4217022),aa:Ser,
seq:gct)
/note="codon recognized: AGC; serT, tRNA-Ser, anticodon
gct, length = 89"
gene 4217134..4218195
/gene="hisC2"
/locus_tag="Rv3772"
CDS 4217134..4218195
/codon_start=1
/transl_table=11
/gene="hisC2"
/locus_tag="Rv3772"
/product="Probable histidinol-phosphate aminotransferase
HisC2 (imidazole acetol-phosphate transaminase)
(imidazolylacetolphosphate aminotransferase)"
/note="Rv3772, (MTCY13D12.06), len: 353 aa. Probable
hisC2,histidinol-phosphate aminotransferase, highly
similar to Q9ZBY8|SCD78.11 putative histidinol-phophate
aminotransferase from Streptomyces coelicolor (359
aa),FASTA scores: opt: 1165, E(): 7.1e-64, (52.55%
identity in 356 aa overlap); and similar to many e.g.
Q9EYX2 from Gardnerella vaginalis (317 aa) FASTA scores:
opt: 814, E(): 1.7e-42, (45.15% identity in 308 aa
overlap); Q9CMI7|HISH_1PM0838|HISH from Pasteurella
multocida (365 aa), FASTA scores: opt: 701, E(): 1.5e-35,
(35.05% identity in 351 aa overlap);
O07131|HIS8_METFL|HISC|HISH from Methylobacillus
flagellatum (368 aa), FASTA scores: opt: 645, E(): 4e-32,
(34.5% identity in 345 aa overlap); etc. Contains PS00599
Aminotransferases class-II pyridoxal-phosphate attachment
site. Belongs to class-II of pyridoxal-phosphate-dependent
aminotransferases. Cofactor: pyridoxal phosphate."
/db_xref="EnsemblGenomes-Gn:Rv3772"
/db_xref="EnsemblGenomes-Tr:CCP46601"
/db_xref="GOA:P9WML5"
/db_xref="InterPro:IPR001917"
/db_xref="InterPro:IPR004839"
/db_xref="InterPro:IPR005861"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="InterPro:IPR024892"
/db_xref="PDB:4R2N"
/db_xref="PDB:4R5Z"
/db_xref="UniProtKB/Swiss-Prot:P9WML5"
/inference="protein motif:PROSITE:PS00599"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46601.1"
/translation="MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAI
DRATDTVNRYPDNGCVQLKAALARHLGPDFAPEHVAVGCGSVSLCQQLVQVTASVGDE
VVFGWRSFELYPPQVRVAGAIPIQVPLTDHTFDLYAMLATVTDRTRLIFVCNPNNPTS
TVVGPDALARFVEAVPAHILIAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKA
YGLAGLRIGYAIGHPDVITALDKVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAE
RARVSAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIVVRPYGTDGVRVTVA
APEENDAFLRFARRWRSDQ"
gene complement(4218241..4218825)
/locus_tag="Rv3773c"
CDS complement(4218241..4218825)
/codon_start=1
/transl_table=11
/locus_tag="Rv3773c"
/product="Conserved protein"
/note="Rv3773c, (MTCY13D12.07c), len: 194 aa. Conserved
protein, highly similar to C-terminal end of
O53773|Rv0576|MTV039.14 possible transcriptional regulator
from Mycobacterium tuberculosis (434 aa), FASTA scores:
opt: 575, E(): 8.3e-30, (47.4% identity in 192 aa
overlap); and some similarity with other proteins from
Mycobacterium tuberculosis e.g. P71985|Rv1727|MTCY04C12.12
(189 aa) FASTA scores: opt: 176, E(): 0.00022, (31.1%
identity in 180 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3773c"
/db_xref="EnsemblGenomes-Tr:CCP46602"
/db_xref="GOA:P72040"
/db_xref="InterPro:IPR017517"
/db_xref="InterPro:IPR017520"
/db_xref="InterPro:IPR034660"
/db_xref="UniProtKB/TrEMBL:P72040"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46602.1"
/translation="MPPESRPGPDSPPTDELACAEAALQVLQQVLHTIGRQDKAKQTP
CPGYDVKKLTEHLLNSIMVLGGMVGAEFSLRADIDSVERLVSGAARSALDAWHRHGLE
GDVSLGPGSMSAKVAVSVFSVEFLVHAWDYAVAVGSELKAADSLAEYVLELARKLIKP
EERSVAGFNEPVDVPEDGGALERLIAFTGRNPAR"
gene 4218849..4219673
/gene="echA21"
/locus_tag="Rv3774"
CDS 4218849..4219673
/codon_start=1
/transl_table=11
/gene="echA21"
/locus_tag="Rv3774"
/product="Possible enoyl-CoA hydratase EchA21 (enoyl
hydrase) (unsaturated acyl-CoA hydratase) (crotonase)"
/note="Rv3774, (MTCY13D12.08), len: 274 aa. Possible
echA21, enoyl-CoA hydratase, equivalent to
Q9CD94|ECHA1|ML0120 putative enoyl-CoA hydratase from
Mycobacterium leprae (278 aa), FASTA scores: opt:
1593,E(): 2.2e-92, (88.3% identity in 274 aa overlap).
Also similar to others e.g. Q9I2S4|PA1821 from Pseudomonas
aeruginosa (270 aa), FASTA scores: opt: 761, E():
2e-40,(42.3% identity in 267 aa overlap); Q9FHR8 from
Arabidopsis thaliana (Mouse-ear cress) (278 aa) FASTA
scores: opt: 638,E(): 9.9e-33, (39.4% identity in 269 aa
overlap); Q9AB78|CC0353 from Caulobacter crescentus (286
aa), FASTA scores: opt: 601, E(): 2.1e-31, (39.25%
identity in 266 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3774"
/db_xref="EnsemblGenomes-Tr:CCP46603"
/db_xref="GOA:P75019"
/db_xref="InterPro:IPR001753"
/db_xref="InterPro:IPR014748"
/db_xref="InterPro:IPR029045"
/db_xref="UniProtKB/TrEMBL:P75019"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46603.1"
/translation="MGETYESVTVETKDQVAQVTLIGPGKGNAMGPAFWSEMPEVFHA
LDADREVRAIVITGSGKNFSYGLDVPAMGGMFAPLIADGALARPRTDFHTEILRMQKA
INAVADCRTPTIAAVQGWCIGGAVDLISAVDIRYASADAKFSVREVKLAIVADMGSLA
RLPLILSDGHLRELALTGKNIDAARAEKIGLVNDVYDDADQTLAAAHATAAEIAANPP
LAVYGIKDVLDQQRTSAVSENLRYVAAWNAAFLPSKDLTEGISATFAKRPPQFTGE"
gene 4219685..4220932
/gene="lipE"
/locus_tag="Rv3775"
CDS 4219685..4220932
/codon_start=1
/transl_table=11
/gene="lipE"
/locus_tag="Rv3775"
/product="Probable lipase LipE"
/note="Rv3775, (MTCY13D12.09), len: 415 aa. Probable
lipE,hydrolase lipase, equivalent to Q9CD95|LIPE|ML0119
probable hydrolase from Mycobacterium leprae (411 aa),
FASTA scores: opt: 2418, E(): 6.4e-144, (84.75% identity
in 406 aa overlap). Also similar to other esterases e.g.
Q9ABH2|CC0255 esterase a from Caulobacter crescentus (374
aa), FASTA scores: opt: 427, E(): 2.4e-19, (28.9% identity
in 391 aa overlap); O87861|ESTA esterase a from
Streptomyces chrysomallus (389 aa), FASTA scores: opt:
417,E(): 1e-18, (31.0% identity in 361 aa overlap);
Q9RK50|SCF12.08 putative esterase from Streptomyces
coelicolor (376 aa), FASTA scores: opt: 385, E():
1e-16,(31.35% identity in 373 aa overlap); etc. Also
similar to proteins from Mycobacterium tuberculosis e.g.
P71778|Rv1497|MTCY277.19 hypothetical 45.8 KDA protein
(429 aa), FASTA scores: opt: 457, E(): 3.5e-21, (30.4%
identity in 395 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3775"
/db_xref="EnsemblGenomes-Tr:CCP46604"
/db_xref="GOA:P72041"
/db_xref="InterPro:IPR001466"
/db_xref="InterPro:IPR012338"
/db_xref="UniProtKB/TrEMBL:P72041"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46604.1"
/translation="MRAGDGKIRVPADLDAVTATGEEDHSEIDGAAVDRIWRAARHWY
RAGMHPAIQLCIRHHGRVVLNRAIGHGWGNAPTDEADAEKIPVTTDTPFCVYSAAKAI
TATVVHMLVERGHFALDDRVCEYLPSYTSHGKHRTTIRHVLTHSAGVPFPTGPRPDVR
RADDHEYAVERLGELRPLYRPGLVHIYHALTWGPLMREIVYAATGKEIREILATEILD
PLGFRWTNFGVAERDVPLVAPSHATGRQLPPVIAAVFRKAIGGTVHEIIPYTNTPFFL
STILPSSNTVSTANELSRFMEILRRGGELDGVRVLSPETLRGAVTECRRLRPDFATGL
MPLRWGTGFMLGSAKYGPFGRNAPAAFGHLGLVNIAVWADPERALSGGLISSGKPGRD
PEAGRYGALLNAITAEIPRASSG"
gene 4221089..4222648
/locus_tag="Rv3776"
CDS 4221089..4222648
/codon_start=1
/transl_table=11
/locus_tag="Rv3776"
/product="Conserved hypothetical protein"
/note="Rv3776, (MTCY13D12.10), len: 519 aa. Conserved
hypothetical protein, highly similar to
Q10709|YL00_MYCTU|Rv2100|MTCY49.40 hypothetical 58.9 KDA
protein from Mycobacterium tuberculosis (550 aa) FASTA
scores: opt: 1646, E(): 1.2e-83, (77.85% identity in 510
aa overlap) (homology from potential start at 7744); and
similar to other proteins from Mycobacterium tuberculosis
(strains H37Rv and CDC1551) e.g. O33266|Rv0336|MTCY279.03
(503 aa) FASTA scores: opt: 682, E(): 2.2e-30, (41.65%
identity in 497 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3776"
/db_xref="EnsemblGenomes-Tr:CCP46605"
/db_xref="GOA:P72042"
/db_xref="InterPro:IPR003615"
/db_xref="InterPro:IPR003870"
/db_xref="UniProtKB/Swiss-Prot:P72042"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46605.1"
/translation="MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGARRLSAIAE
LTSRRTGNDQRADWACDGWDCAAAEVAAALTVSHRKASGQMHLSLTLNRLPQVAALFL
AGQLSARLVSIIAWRTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRY
DPAALRRTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDD
PRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAA
PDPRLSGPEPALAPEAPATPAVKPPAALISGGGVVPAPLLAELIRGGAALSRMRHPGD
LRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYPLGPTHPSNLKCLC
RKHHLLKTFWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPS
PPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDTAVAEGFEPPDG
VSRLSLSRRVH"
gene complement(4222581..4222667)
/gene="serU"
tRNA complement(4222581..4222667)
/gene="serU"
/product="tRNA-Ser"
/anticodon=(pos:complement(4222631..4222633),aa:Ser,
seq:tga)
/note="codon recognized: UCA; serU, tRNA-Ser, anticodon
tga, length = 87"
gene 4222694..4223680
/locus_tag="Rv3777"
CDS 4222694..4223680
/codon_start=1
/transl_table=11
/locus_tag="Rv3777"
/product="Probable oxidoreductase"
/note="Rv3777, (MTCY13D12.11), len: 328 aa. Probable
oxidoreductase, equivalent to Q9CD96|ML0118 putative
oxidoreductase from Mycobacterium leprae (336 aa) FASTA
scores: opt: 1661, E(): 1.1e-87, (76.0% identity in 325 aa
overlap). Also highly similar to many e.g.
Q9XA55|SCGD3.24c putative quinone oxidoreductase from
Streptomyces coelicolor (326 aa) FASTA scores: opt: 1118,
E(): 1.3e-64,(59.6% identity in 312 aa overlap);
O65423|F18E5.200|F17L22.40|AT4G21580 putative NADPH
quinone oxidoreductase from Arabidopsis thaliana
(Mouse-ear cress) (325 aa), FASTA scores: opt: 1110, E():
3e-56, (52.15% identity in 326 aa overlap); Q98FI0|MLL3767
NADPH quinone oxidoreductase from Rhizobium loti
(Mesorhizobium loti) (326 aa), FASTA scores: opt: 980,
E(): 7.9e-49, (47.85% identity in 324 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3777"
/db_xref="EnsemblGenomes-Tr:CCP46606"
/db_xref="GOA:P72043"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR014189"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P72043"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46606.1"
/translation="MTIMRAVVAESSDRLVWQEVPDVSAGPGEVLIKVAASGVNRADV
LQAAGKYPPPPGVSDIIGLEVSGIVAAVGPGVTEWSAGQEVCALLAGGGYAEYVAVPA
DQVLPIPPSVNLVDSAALPEVACTVWSNLVMTAHLRPGQLVLIHGGASGIGSHAIQVV
RALAARVAITAGSPEKLELCRDLGAQITINYRDEDFVARLKQETDGSGADIILDIMGA
SYLDRNIDALATDGQLIVIGMQGGVKAELNLGKLLTKRARVIGTTLRARPVSGPHGKA
AIAQAVAASVWPMIAANRVRPVIGTRLPIQQAAQAHELMLSGKTFGKILLTV"
gene complement(4223699..4224895)
/locus_tag="Rv3778c"
CDS complement(4223699..4224895)
/codon_start=1
/transl_table=11
/locus_tag="Rv3778c"
/product="Possible aminotransferase"
/note="Rv3778c, (MTCY13D12.12c), len: 398 aa. Possible
aminotransferase, equivalent to Q9CD97|ML0117 hypothetical
protein from Mycobacterium leprae (398 aa) FASTA scores:
opt: 2141, E(): 1.2e-123, (83.4% identity in 398 aa
overlap). Also similar to other aminotransferases and
cysteine desulfurases e.g. Q9K3K6|SCG20A.34 putative
aminotransferase from Streptomyces coelicolor (400
aa),FASTA scores: opt: 723, E(): 6.5e-37, (36.3% identity
in 402 aa overlap); Q9KSS2|VC1184 NIFS-related protein
(aminotransferase-related) from Vibrio cholerae (416 aa)
FASTA scores: opt: 595, E(): 4.5e-29, (31.35% identity in
405 aa overlap); Q98NK4|MLR0102 aminotransferase from
Rhizobium loti (Mesorhizobium loti) (425 aa), FASTA
scores: opt: 563, E(): 4.2e-27, (29.4% identity in 408 aa
overlap); Q9RY03|DR0151 NIFS-related protein from
Deinococcus radiodurans (401 aa), FASTA scores: opt: 484,
E(): 2.7e-22,(32.35% identity in 399 aa overlap);
Q9A766|CC1860 aminotransferase class V from Caulobacter
crescentus (408 aa), FASTA scores: opt: 390, E(): 1.5e-16,
(27.85% identity in 413 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3778c"
/db_xref="EnsemblGenomes-Tr:CCP46607"
/db_xref="GOA:P9WQ67"
/db_xref="InterPro:IPR000192"
/db_xref="InterPro:IPR011340"
/db_xref="InterPro:IPR015421"
/db_xref="InterPro:IPR015422"
/db_xref="InterPro:IPR015424"
/db_xref="PDB:3CAI"
/db_xref="UniProtKB/Swiss-Prot:P9WQ67"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46607.1"
/translation="MAYDVARVRGLHPSLGDGWVHFDAPAGMLIPDSVATTVSTAFRR
SGASTVGAHPSARRSAAVLDAAREAVADLVNADPGGVVLGADRAVLLSLLAEASSSRA
GLGYEVIVSRLDDEANIAPWLRAAHRYGAKVKWAEVDIETGELPTWQWESLISKSTRL
VAVNSASGTLGGVTDLRAMTKLVHDVGALVVVDHSAAAPYRLLDIRETDADVVTVNAH
AWGGPPIGAMVFRDPSVMNSFGSVSTNPYATGPARLEIGVHQFGLLAGVVASIEYLAA
LDESARGSRRERLAVSMQSADAYLNRVFDYLMVSLRSLPLVMLIGRPEAQIPVVSFAV
HKVPADRVVQRLADNGILAIANTGSRVLDVLGVNDVGGAVTVGLAHYSTMAEVDQLVR
ALASLG"
gene 4224985..4226985
/locus_tag="Rv3779"
CDS 4224985..4226985
/codon_start=1
/transl_table=11
/locus_tag="Rv3779"
/product="Probable conserved transmembrane protein alanine
and leucine rich"
/note="Rv3779, (MTCY13D12.13), len: 666 aa. Predicted to
be in the GT-C superfamily of glycosyltransferases (See
Liu and Mushegian, 2003). Probable conserved transmembrane
ala-, leu-rich protein, equivalent to Q9CD98|ML0116
putative membrane protein from Mycobacterium leprae (654
aa), FASTA scores: opt: 1991, E(): 2e-112, (66.5% identity
in 666 aa overlap). Shows some similarity with
Q9RRU0|DR2395 putative NA+/H+ antiporter from Deinococcus
radiodurans (458 aa), FASTA scores: opt: 138, E():
0.69,(31.9% identity in 138 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3779"
/db_xref="EnsemblGenomes-Tr:CCP46608"
/db_xref="GOA:P72045"
/db_xref="UniProtKB/TrEMBL:P72045"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46608.1"
/translation="MGLWFGTLIALILLIAPGAMVARIAQLRWPVAIAVGPALTYGVV
ALAIIPYGALGIPWNGWTALAALAVTCAVATGLQLLLARFRDLDAEALAVSRWPAVTV
AAGVLLGALLIGWAAYRGIPHWQSIPSTWDAVWHANTVRFILDTGQASSTHMGELRNV
ETHAPLYYPSVFHGLVAVFCQLTGAAPTTGYTLSSLAASVWLFPVSAAVLTWRAVRSH
PGALWSASCASAEWRAAGAAGTAAALSASFTAVPYVEFDTAAMPNLAAYGIAVPTMVL
ITSTLRHRDRIPVAVLALVGVFSLHITGGIVVALLVSAWWLFEALRHPVRSRLADLLT
LAGVAAMAGLVMLPQFLSVRQQEDIIAGHAFPTYLSKKRGLFDAVFQHSRHLNDFPVQ
YALIVLAAIGGLILLVKKIWWPLAVWLLLIVMNVDAGTPLGGPIGGVAGALGEFFYHD
PRRIAAATTLLLMLMAGVALFATVMLLVAAAKRLTDRFRPQPVSVWASATATLLIGAT
LVSAWHYFPRHRFLFGDKYDSVMIDQKDLDAMAYLASLPGARDTLIGNANTDGTAWMY
AVAGLHPLWTHYDYPLQQGPGYHRFIFWAYGRNGESDPRVLEAIQVLRIRYILTSTPT
VRGFAVPDGLVSLETSRSWAKIYDNGEARIYEWRGTAAATHS"
gene 4226989..4227525
/locus_tag="Rv3780"
CDS 4226989..4227525
/codon_start=1
/transl_table=11
/locus_tag="Rv3780"
/product="Conserved protein"
/note="Rv3780, (MTCY13D12.14), len: 178 aa. Conserved
protein, equivalent to Q9CD99|ML0115 hypothetical 19.1 KDA
protein from Mycobacterium leprae (174 aa), FASTA scores:
opt: 903, E(): 2.3e-48, (82.95% identity in 170 aa
overlap). Also highly similar to Q9XA56|SCGD3.23c
hypothetical 19.5 KDA protein from Streptomyces coelicolor
(179 aa), FASTA scores: opt: 692, E(): 1.8e-35, (65.9%
identity in 170 aa overlap). Note that this putative
protein is 4 aa longer at the N-terminus compared to
previous annotation (in Nature 393: 537-544 (1998))."
/db_xref="EnsemblGenomes-Gn:Rv3780"
/db_xref="EnsemblGenomes-Tr:CCP46609"
/db_xref="GOA:P9WKX3"
/db_xref="InterPro:IPR019695"
/db_xref="PDB:5IET"
/db_xref="PDB:5IEU"
/db_xref="PDB:5LFJ"
/db_xref="PDB:5LFP"
/db_xref="PDB:5LFQ"
/db_xref="PDB:5LZP"
/db_xref="PDB:6BGL"
/db_xref="PDB:6BGO"
/db_xref="UniProtKB/Swiss-Prot:P9WKX3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46609.1"
/translation="MRKRMVIGLSTGSDDDDVEVIGGVDPRLIAVQENDSDESSLTDL
VEQPAKVMRIGTMIKQLLEEVRAAPLDEASRNRLRDIHATSIRELEDGLAPELREELD
RLTLPFNEDAVPSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLQQMRQGAL
PPGVGKSGQHGHGTGQYL"
gene 4227529..4228350
/gene="rfbE"
/locus_tag="Rv3781"
CDS 4227529..4228350
/codon_start=1
/transl_table=11
/gene="rfbE"
/locus_tag="Rv3781"
/product="Probable O-antigen/lipopolysaccharide transport
ATP-binding protein ABC transporter RfbE"
/note="Rv3781, (MTCY13D12.15), len: 273 aa. Probable
rfbE,polysaccharide-transport ATP-binding protein ABC
transporter, involved in O-antigen/lipopolysaccharides
(LPS) transport (see Braibant et al., 2000), equivalent to
Q9CDA0|ML0114 putative ABC transporter ATP-binding
component from Mycobacterium leprae (272 aa), FASTA
scores: opt: 1581, E(): 3e-83, (91.4% identity in 267 aa
overlap). Also highly similar to AAK71283 LPS/O-antigen
export permease from Coxiella burnetii (258 aa), FASTA
scores: opt: 793, E(): 2.5e-38, (45.45% identity in 253 aa
overlap); Q9PAF0|XF2568 ABC transporter ATP-binding
protein from Xylella fastidiosa (246 aa), FASTA scores:
opt: 758,E(): 2.4e-36, (47.75% identity in 243 aa
overlap); Q56903|RFBE_YEREN O-antigen export system
ATP-binding protein from Yersinia enterocolitica (239 aa)
(see Zhang et al., 1993), FASTA scores: opt: 697, E():
7e-33, (48.65% identity in 224 aa overlap);
Q50863|RFBB_MYXXA O-antigen export system ATP-binding from
Myxococcus xanthus (437 aa),FASTA scores: opt: 605, E():
2e-27, (42.05% identity in 207 aa overlap); etc. Contains
PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to
the ATP-binding transport protein family (ABC
transporters)."
/db_xref="EnsemblGenomes-Gn:Rv3781"
/db_xref="EnsemblGenomes-Tr:CCP46610"
/db_xref="GOA:P72047"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P72047"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46610.1"
/translation="MSDPHHPHIQTHNAWVEFPIFDAKSRSLKKAVLGKAGGTIGRNN
SNVVVIEALRDITMELNLGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGWAKVTGRVAP
VFDLGIGMDPEISGYENIIIRGLFLGQTRKQMQAKVDEIAEFTELGEYLSMPLRTYST
GMRVRLAMGVVTSIDPEILLLDEGIGAVDADFLRKAQSRLQNLVERSGILVFASHSNE
FLARLCKTAIWIDHGVIRLAGGIEEVVRAYEGEDAARHVREVLAETQADRQNVQG"
gene 4228347..4229261
/gene="glfT1"
/gene_synonym="rfbE"
/locus_tag="Rv3782"
CDS 4228347..4229261
/codon_start=1
/transl_table=11
/gene="glfT1"
/gene_synonym="rfbE"
/locus_tag="Rv3782"
/product="UDP-galactofuranosyl transferase GlfT1"
/note="Rv3782, (MTCY13D12.16), len: 304 aa.
GlfT1,UDP-galactofuranosyl transferase (See Mikusova et
al.,2006; Belanova et al., 2008), equivalent to
Q9CDA1|RFBE|ML0113 putative glycosyl transferase from
Mycobacterium leprae (283 aa), FASTA scores: opt:
1583,E(): 9.3e-96, (81.6% identity in 277 aa overlap).
Also some similarity with AAK68916|WCFN putative
glycosyltransferase from Bacteroides fragilis (291 aa)
FASTA scores: opt: 241,E(): 2.1e-08, (30.75% identity in
195 aa overlap); O58161|PH0424 hypothetical 40.5 KDA
protein from Pyrococcus horikoshii (348 aa), FASTA scores:
opt: 194, E(): 2.8e-05,(23.85% identity in 302 aa
overlap); O26448|MTH348 rhamnosyl transferase from
Methanothermobacter thermautotrophicus (313 aa), FASTA
scores: opt: 177, E(): 0.00033, (28.2% identity in 333 aa
overlap); O07868|CPS19BQ putative rhamnosyl transferase
FASTA from Streptococcus pneumoniae (300 aa), FASTA
scores: opt: 156, E(): 0.0074,(25.45% identity in 232 aa
overlap); and other putative transferases. Note that
C-terminal end shows some similarity with part of
Q05161|RFB O-antigen biosynthesis protein B from
Escherichia coli strain 0101. Note that previously known
as rfbE."
/db_xref="EnsemblGenomes-Gn:Rv3782"
/db_xref="EnsemblGenomes-Tr:CCP46611"
/db_xref="GOA:P9WMX3"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WMX3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46611.1"
/translation="MTESVFAVVVTHRRPDELAKSLDVLTAQTRLPDHLIVVDNDGCG
DSPVRELVAGQPIATTYLGSRRNLGGAGGFALGMLHALAQGADWVWLADDDGHAQDAR
VLATLLACAEKYSLAEVSPMVCNIDDPTRLAFPLRRGLVWRRRASELRTEAGQELLPG
IASLFNGALFRASTLAAIGVPDLRLFIRGDEVEMHRRLIRSGLPFGTCLDAAYLHPCG
SDEFKPILCGRMHAQYPDDPGKRFFTYRNRGYVLSQPGLRKLLAQEWLRFGWFFLVTR
RDPKGLWEWIRLRRLGRREKFGKPGGSA"
gene 4229258..4230100
/gene="rfbD"
/locus_tag="Rv3783"
CDS 4229258..4230100
/codon_start=1
/transl_table=11
/gene="rfbD"
/locus_tag="Rv3783"
/product="Probable O-antigen/lipopolysaccharide transport
integral membrane protein ABC transporter RfbD"
/note="Rv3783, (MTCY13D12.17), len: 280 aa. Probable
rfbD,polysaccharide-transport integral membrane protein
ABC transporter (see Braibant et al., 2000), involved in
O-antigen/lipopolysaccharides (LPS) transport, equivalent
to Q9CDA2|ML0112 putative ABC transporter component from
Mycobacterium leprae (276 aa), FASTA scores: opt:
1646,E(): 4e-102, (84.3% identity in 280 aa overlap). Also
highly similar to Q9PAF1|XF2567 ABC transporter permease
protein from Xylella fastidiosa (267 aa), FASTA scores:
opt: 723, E(): 7.6e-41, (41.3% identity in 259 aa
overlap); and similar to others e.g. Q56902|RFBD_YEREN
O-antigen export system permease protein from Yersinia
enterocolitica (259 aa) (see Zhang et al., 1993), FASTA
scores: opt: 566,E(): 2e-30, (28.05% identity in 264 aa
overlap); Q06955|RFBH RFBH protein (involved in the export
of lipopolysaccharide) (alias Q9KVA3|VC0246)
lipopolysaccharide/O-antigen transport protein from Vibrio
cholerae (257 aa), FASTA scores: opt: 358, E():
1.3e-16,(24.4% identity in 258 aa overlap);
Q9HTB8|WZM|PA5451 membrane subunit of a-band LPS efflux
transporter from Pseudomonas aeruginosa (265 aa), FASTA
scores: opt: 263,E(): 2.7e-10, (25.45% identity in 263 aa
overlap); etc. Belongs to the ABC-2 subfamily of integral
membrane proteins."
/db_xref="EnsemblGenomes-Gn:Rv3783"
/db_xref="EnsemblGenomes-Tr:CCP46612"
/db_xref="GOA:P72049"
/db_xref="InterPro:IPR013525"
/db_xref="UniProtKB/TrEMBL:P72049"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46612.1"
/translation="MTFMDAQASFQTQSRTLARVRGDLVDGFRRHELWLHLGWQDIKQ
RYRRSVLGPFWITIATGTTAVAMGGLYSKLFRLELSEHLPYVTLGLIVWNLINAAILD
GAEVFVANEGLIKQLPAPLSVHVYRLVWRQMIFFAHNIVIYFVIAIIFPKPWSWADLS
FLPALALIFLNCVWVSLCFGILATRYRDIGPLLFSVVQLLFFMTPIIWNDETLRRQGA
GRWSSIVELNPLLHYLDIVRAPLLGAHQELRHWLVVLVLTVVGWMLAAFAMRQYRARV
PYWV"
gene 4230256..4231236
/gene_synonym="epiB"
/locus_tag="Rv3784"
CDS 4230256..4231236
/codon_start=1
/transl_table=11
/gene_synonym="epiB"
/locus_tag="Rv3784"
/product="Possible dTDP-glucose 4,6-dehydratase"
/note="Rv3784, (MTCY13D12.18), len: 326 aa. Possible
dTDP-glucose 4,6-dehydratase, but experimental study shown
that the purified protein didn't have dTDP-glucose
dehydratase (rmlB) activity (see citation below). Similar
to others e.g. Q9YCT1|APE1180 long hypothetical
dTDP-glucose 4,6-dehydratase from Aeropyrum pernix (330
aa) FASTA scores: opt: 598, E(): 3.7e-30, (34.9% identity
in 315 aa overlap); O27817|MTH1789 dTDP-glucose
4,6-dehydratase from Methanothermobacter
thermautotrophicus (336 aa) FASTA scores: opt: 587, E():
1.8e-29, (34.9% identity in 315 aa overlap); Q9X5W0|GRSE
TDP-glucose-4,6-dehydratase homolog from Streptomyces
griseus (324 aa), FASTA scores: opt: 583, E():
3.2e-29,(35.7% identity in 325 aa overlap);
Q9K7J7|SPSJ|BH3364 spore coat polysaccharide synthesis
(dTDP glucose 4,6-dehydratase) from Bacillus halodurans
(321 aa), FASTA scores: opt: 562, E(): 6.5e-28, (33.0%
identity in 318 aa overlap); Q9UZH2|RFBB|PAB0785
dTDP-glucose 4,6-dehydratase from Pyrococcus abyssi (333
aa), FASTA scores: opt: 552,E(): 2.8e-27, (33.95% identity
in 318 aa overlap); P27830|RFFG_ECOLI|B3788 dTDP-glucose
4,6-dehydratase from Escherichia coli strain K12 (355 aa),
FASTA scores: opt: 401, E(): 7.5e-28, (31.3% identity in
348 aa overlap); etc. But also similar to several
UDP-glucose 4-epimerases and other proteins e.g.
O59375|PH1742 long hypothetical UDP-glucose 4-epimerase
from Pyrococcus horikoshii (306 aa) FASTA scores: opt:
600, E(): 2.6e-30, (34.5% identity in 313 aa overlap);
Q9ZGC7|LANH14 NDP-hexose 4,6-dehydratase HOMOLOGfrom
Streptomyces cyanogenus (326 aa), FASTA scores: opt: 593,
E(): 7.6e-30, (36.45% identity in 321 aa overlap);
Q57664|GALE_METJA|MJ0211 putative UDP-glucose 4-epimerase
from Methanococcus jannaschii (305 aa) FASTA scores: opt:
575, E(): 9.6e-29, (32.6% identity in 313 aa overlap);
etc. Seems to belong to the sugar epimerase family,
dTDP-glucose dehydratase subfamily. Note that previously
known as epiB."
/db_xref="EnsemblGenomes-Gn:Rv3784"
/db_xref="EnsemblGenomes-Tr:CCP46613"
/db_xref="InterPro:IPR016040"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:P72050"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46613.1"
/translation="MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGF
RSHDRAAFISGSVTDGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYR
VLEAVRRYRNRLIYVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYS
YFRSYGLDVTIVRPFNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLY
VSDIVGAYNLVLRTPTLRGQAINFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQ
RFPADISLAKSIGFQPQVEIWDGIDRYINWAKDQPQYPYEQDGFSGSSVL"
gene 4231320..4232393
/locus_tag="Rv3785"
CDS 4231320..4232393
/codon_start=1
/transl_table=11
/locus_tag="Rv3785"
/product="Hypothetical protein"
/note="Rv3785, (MTCY13D12.19), len: 357 aa. Hypothetical
unknown protein. Note that this putative protein is
equivalent to AAK48258|MT3893 NAD-dependent
epimerase/dehydratase family protein from Mycobacterium
tuberculosis strain CDC1551 (712 aa), but shorter 355 aa."
/db_xref="EnsemblGenomes-Gn:Rv3785"
/db_xref="EnsemblGenomes-Tr:CCP46614"
/db_xref="GOA:P9WKX1"
/db_xref="UniProtKB/Swiss-Prot:P9WKX1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46614.1"
/translation="MVTVARRPVCPVTLTPGDPALASVRDLVDAWSAHDALAELVTMF
GGAFPQTDHLEARLASLDKFSTAWDYRARARAARALHGEPVRCQDSGGGARWLIPRLD
LPAKKRDAIVGLAQQLGLTLESTPQGTTFDHVLVIGTGRHSNLIRARWARELAKGRQV
GHIVLAAASRRLLPSEDDAVAVCAPGARTEFELLAAAARDAFGLDVHPAVRYVRQRDD
NPHRDSMVWRFAADTNDLGVPITLLEAPSPEPDSSRATSADTFTFTAHTLGMQDSTCL
LVTGQPFVPYQNFDALRTLALPFGIQVETVGFGIDRYDGLGELDQQHPAKLLQEVRST
IRAARALLERIEAGERMATDPRR"
gene complement(4232374..4233597)
/locus_tag="Rv3786c"
CDS complement(4232374..4233597)
/codon_start=1
/transl_table=11
/locus_tag="Rv3786c"
/product="Unknown protein"
/note="Rv3786c, (MTCY13D12.20), len: 407 aa. Unknown
protein. Segment between aa 265-300 (approximately) is
highly similar to part of O03937|RORF1608 minor capsid
protein from Bacteriophage phig1e (1608 aa), FASTA scores:
opt: 242, E(): 8.4e-07, (26.85% identity in 272 aa
overlap); Q9ETT9|ORF36 putative peptidase from
Corynebacterium equii (Rhodococcus equi) plasmid pREAT701
(p33701) and Plasmid virulence (546 aa), FASTA scores:
opt: 231, E(): 1.6e-06, (34.15% identity in 167 aa
overlap); O69910|SC2E1.40c hypothetical 22.8 KDA protein.
from Streptomyces coelicolor (226 aa) FASTA scores: opt:
218,E(): 4.6e-06, (34.15% identity in 164 aa overlap); and
others."
/db_xref="EnsemblGenomes-Gn:Rv3786c"
/db_xref="EnsemblGenomes-Tr:CCP46615"
/db_xref="GOA:P9WKW9"
/db_xref="InterPro:IPR011055"
/db_xref="InterPro:IPR016047"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/Swiss-Prot:P9WKW9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46615.1"
/translation="MRILAMTRAHNAGRTLAATLDSLAVFSDDIYVIDDRSTDDTAEI
LANHPAVTNVVRARPDLPPTPWLIPESAGLELLYRMADFCRPDWVMMVDADWLVETDI
DLRAVLARTPDDIVALMCPMVSRWDDPEYPDLIPVMGTAEALRGPLWRWYPGLRAGGK
LMHNPHWPANITDHGRIGQLPGVRLVHSGWSTLAERILRVEHYLRLDPDYRFNFGVAY
DRSLLFGYALDEVDLLKADYRRRIRGDFDPLEPGGRLPIDREPRAIGRGYGPHAGGFH
PGVDFATDPGTPVYAVASGAVSAIDEVDGLVSLTIARCELDVVYVFRPGDEGRLVLGD
RIAAGAQLGTIGAQGESADGYLHFEVRTQDGHVNPVRYLANMGLRPWPPPGRLRAVSG
SYPPATPCTITAEDR"
gene complement(4233610..4234536)
/locus_tag="Rv3787c"
CDS complement(4233610..4234536)
/codon_start=1
/transl_table=11
/locus_tag="Rv3787c"
/product="Conserved hypothetical protein"
/note="Rv3787c, (MTCY13D12.21), len: 308 aa. Conserved
hypothetical protein, highly similar to several
mycobacterial hypothetical proteins e.g.
P95074|Rv0726c|MTCY210.45c from Mycobacterium tuberculosis
(367 aa), FASTA scores: opt: 1038, E(): 1.6e-58, (55.85%
identity in 283 aa overlap);
O53795|MBE50c|Rv0731c|MTV041.05c from Mycobacterium
tuberculosis (318 aa), FASTA scores: opt: 1030, E():
4.5e-58, (56.15% identity in 292 aa overlap);
Q9CCZ4|ML2640 from Mycobacterium leprae (310 aa) FASTA
scores: opt: 709,E(): 9.9e-38, (43.75% identity in 279 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3787c"
/db_xref="EnsemblGenomes-Tr:CCP46616"
/db_xref="GOA:P9WFH3"
/db_xref="InterPro:IPR007213"
/db_xref="InterPro:IPR011610"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WFH3"
/protein_id="CCP46616.1"
/translation="MARTDDDSWDLATGVGATATLVAAGRARAARAAQPLIDDPFAEP
LVRAVGVEFLTRWATGELDAADVDDPDAAWGLQRMTTELVVRTRYFDQFFLDAAAAGV
RQAVILASGLDARGYRLPWPADTTVFEVDQPRVLEFKAQTLAGLGAQPTADLRMVPAD
LRHDWPDALRRGGFDAAEPAAWIAEGLFGYLPPDAQNRLLDHVTDLSAPGSRLALEAF
LGSADRDSARVEEMIRTATRGWREHGFHLDIWALNYAGPRHEVSGYLDNHGWRSVGTT
TAQLLAAHDLPAAPALPAGLADRPNYWTCVLG"
gene 4234780..4235265
/locus_tag="Rv3788"
CDS 4234780..4235265
/codon_start=1
/transl_table=11
/locus_tag="Rv3788"
/product="Hypothetical protein"
/note="Rv3788, (MTCY13D12.22), len: 161 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3788"
/db_xref="EnsemblGenomes-Tr:CCP46617"
/db_xref="GOA:P9WKW7"
/db_xref="InterPro:IPR001437"
/db_xref="InterPro:IPR023459"
/db_xref="InterPro:IPR036953"
/db_xref="UniProtKB/Swiss-Prot:P9WKW7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46617.1"
/translation="MSEKVESKGLADAARDHLAAELARLRQRRDRLEVEVKNDRGMIG
DHGDAAEAIQRADELAILGDRINELDRRLRTGPTPWSGSETLPGGTEVTLRFPDGEVV
TMHVISVVEETPVGREAETLTARSPLGQALAGHQPGDTVTYSTPQGPNQVQLLAVKLP
S"
gene 4235374..4235739
/locus_tag="Rv3789"
CDS 4235374..4235739
/codon_start=1
/transl_table=11
/locus_tag="Rv3789"
/product="GTRA family protein"
/note="Rv3789, (MTCY13D12.23), len: 121 aa. GtrA family
protein; possible integral membrane protein, equivalent to
Q9CDA3|ML0110 hypothetical 13.9 KDA protein from
Mycobacterium leprae (123 aa) FASTA scores: opt: 587, E():
7.3e-34, (72.95% identity in 122 aa overlap). Also
equivalent to AAK48262 from Mycobacterium tuberculosis
strain CDC1551 (142 aa) but shorter 21 aa."
/db_xref="EnsemblGenomes-Gn:Rv3789"
/db_xref="EnsemblGenomes-Tr:CCP46618"
/db_xref="GOA:P9WMS9"
/db_xref="InterPro:IPR007267"
/db_xref="UniProtKB/Swiss-Prot:P9WMS9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46618.1"
/translation="MRFVVTGGLAGIVDFGLYVVLYKVAGLQVDLSKAISFIVGTITA
YLINRRWTFQAEPSTARFVAVMLLYGITFAVQVGLNHLCLALLHYRAWAIPVAFVIAQ
GTATVINFIVQRAVIFRIR"
gene 4235779..4237164
/gene="dprE1"
/locus_tag="Rv3790"
CDS 4235779..4237164
/codon_start=1
/transl_table=11
/gene="dprE1"
/locus_tag="Rv3790"
/product="Decaprenylphosphoryl-beta-D-ribose 2'-oxidase"
/note="Rv3790, (MTCY13D12.24), len: 461 aa.
DprE1,decaprenylphosphoryl-beta-D-ribose 2'-oxidase,
equivalent to Q9CDA4|ML0109 putative FAD-linked
oxidoreductase from Mycobacterium leprae (460 aa), FASTA
scores: opt: 2722,E(): 1.4e-161, (86.55% identity in 461
aa overlap). Also highly similar to others e.g.
Q9KZA4|SC5G8.10c putative oxidoreductase from Streptomyces
coelicolor (457 aa), FASTA scores: opt: 1336, E():
1.7e-75, (47.1% identity in 452 aa overlap);
Q98KY4|MLL1265 probable oxidoreductase from Rhizobium loti
(Mesorhizobium loti) (449 aa), FASTA scores: opt: 636,
E(): 4.9e-32, (36.0% identity in 439 aa overlap);
Q9HDX8|SPAPB1A10.12c putative D-arabinono-1,4-lactone
oxidase from Schizosaccharomyces pombe (Fission yeast)
(461 aa), FASTA scores: opt: 297, E(): 5.6e-11, (23.55%
identity in 467 aa overlap); etc. C-terminal end has a
high similarity to Q9AQD0 putative oxidoreductase
(fragment) from Mycobacterium smegmatis (149 aa) FASTA
scores: opt: 901, E(): 6.5e-49, (86.6% identity in 149 aa
overlap). Identified as the target of antimicrobial agent
1,3-benzothiazin-4-ones (BTZs) (See Makarov et al.,
2009)."
/db_xref="EnsemblGenomes-Gn:Rv3790"
/db_xref="EnsemblGenomes-Tr:CCP46619"
/db_xref="GOA:P9WJF1"
/db_xref="InterPro:IPR006094"
/db_xref="InterPro:IPR007173"
/db_xref="InterPro:IPR016166"
/db_xref="InterPro:IPR016169"
/db_xref="InterPro:IPR036318"
/db_xref="PDB:4FDN"
/db_xref="PDB:4FDO"
/db_xref="PDB:4FDP"
/db_xref="PDB:4FEH"
/db_xref="PDB:4FF6"
/db_xref="PDB:4KW5"
/db_xref="PDB:4NCR"
/db_xref="PDB:4P8C"
/db_xref="PDB:4P8H"
/db_xref="PDB:4P8K"
/db_xref="PDB:4P8L"
/db_xref="PDB:4P8M"
/db_xref="PDB:4P8N"
/db_xref="PDB:4P8P"
/db_xref="PDB:4P8T"
/db_xref="PDB:4P8Y"
/db_xref="PDB:4PFA"
/db_xref="PDB:4PFD"
/db_xref="PDB:5OEP"
/db_xref="PDB:5OEQ"
/db_xref="PDB:6HEZ"
/db_xref="PDB:6HF0"
/db_xref="PDB:6HF3"
/db_xref="PDB:6HFV"
/db_xref="PDB:6HFW"
/db_xref="UniProtKB/Swiss-Prot:P9WJF1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46619.1"
/translation="MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAE
SGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLM
KAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRH
LTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSD
GSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLP
DVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQ
YQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPI
KDGLGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVF
ASDMARRLELL"
gene 4237165..4237929
/gene="dprE2"
/locus_tag="Rv3791"
CDS 4237165..4237929
/codon_start=1
/transl_table=11
/gene="dprE2"
/locus_tag="Rv3791"
/product="Decaprenylphosphoryl-D-2-keto erythro pentose
reductase"
/note="Rv3791, (MTCY13D12.25), len: 254 aa.
DprE2,decaprenylphosphoryl-D-2-keto erythro pentose
reductase,equivalent to Q9CDA5|ML0108 putative
oxidoreductase from Mycobacterium leprae (254 aa), FASTA
scores: opt: 1458,E(): 1.6e-83, (89.0% identity in 254 aa
overlap); and O05764 putative protein belonging to the
short-chain alcohol dehydrogenase from Mycobacterium
smegmatis (254 aa), FASTA scores: opt: 1412, E(): 1.2e-80,
(85.05% identity in 254 aa overlap). Also highly similar
to Q9KZA5|SC5G8.09c putative short-chain dehydrogenase
from Streptomyces coelicolor (256 aa), FASTA scores: opt:
733,E(): 1.8e-38, (45.3% identity in 254 aa overlap); and
P43168|YMP3_STRCO hypothetical oxidoreductase from
Streptomyces coelicolor (251 aa), FASTA scores: opt:
623,E(): 1.2e-31, (42.15% identity in 254 aa overlap); and
similar to various oxidoreductases (principally
acetoacetyl-CoA reductases) e.g. P14697|PHBB_ALCEU
acetoacetyl-CoA reductase (246 aa) from Alcaligenes
eutrophus (Ralstonia eutropha) (246 aa) FASTA scores: opt:
264, E(): 2.3e-09, (29.9% identity in 204 aa overlap);
P45375|PHBB_CHRVI acetoacetyl-CoA reductase from
Chromatium vinosum (246 aa), FASTA scores: opt: 261, E():
3.5e-09,(27.45% identity in 226 aa overlap); Q9RT30|DR1938
oxidoreductase (short-chain dehydrogenase/reductase
family) from Deinococcus radiodurans (283 aa), FASTA
scores: opt: 251, E(): 1.7e-08, (27.55% identity in 236 aa
overlap); etc. Also similar to
Q10681|YK73_MYCTU|Rv2073c|MT2133|MTCY49.12 putative
short-chain type dehydrogenase/reductase from
Mycobacterium tuberculosis (249 aa), FASTA scores: opt:
589, E(): 1.5e-29, (41.25% identity in 252 aa overlap).
Contains PS00061 Short-chain dehydrogenases/reductases
family signature. Belongs to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv3791"
/db_xref="EnsemblGenomes-Tr:CCP46620"
/db_xref="GOA:P9WGS9"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR020904"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WGS9"
/inference="protein motif:PROSITE:PS00061"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46620.1"
/translation="MVLDAVGNPQTVLLLGGTSEIGLAICERYLHNSAARIVLACLPD
DPRREDAAAAMKQAGARSVELIDFDALDTDSHPKMIEAAFSGGDVDVAIVAFGLLGDA
EELWQNQRKAVQIAEINYTAAVSVGVLLAEKMRAQGFGQIIAMSSAAGERVRRANFVY
GSTKAGLDGFYLGLSEALREYGVRVLVIRPGQVRTRMSAHLKEAPLTVDKEYVANLAV
TASAKGKELVWAPAAFRYVMMVLRHIPRSIFRKLPI"
gene 4237932..4239863
/gene="aftA"
/locus_tag="Rv3792"
CDS 4237932..4239863
/codon_start=1
/transl_table=11
/gene="aftA"
/locus_tag="Rv3792"
/product="Arabinofuranosyltransferase AftA"
/note="Rv3792, (MTCY13D12.26), len: 643 aa.
aftA,arabinofuranosyltransferase (See Alderwick et al.,
2006). Predicted to be in the GT-C superfamily of
glycosyltransferases (See Liu and Mushegian, 2003).
Probable conserved transmembrane protein, equivalent, but
longer 21 aa, to Q9CDA6|ML0107 putative membrane protein
from Mycobacterium leprae (632 aa), FASTA scores: opt:
1981, E(): 2.1e-110, (77.5% identity in 631 aa overlap).
C-terminal end highly similar to C-terminus of O05765
putative product ORF 3 from Mycobacterium smegmatis (603
aa), FASTA scores: opt: 1261, E(): 1.4e-67, (70.7%
identity in 266 aa overlap). A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004)."
/db_xref="EnsemblGenomes-Gn:Rv3792"
/db_xref="EnsemblGenomes-Tr:CCP46621"
/db_xref="GOA:P9WN03"
/db_xref="InterPro:IPR020959"
/db_xref="InterPro:IPR020963"
/db_xref="UniProtKB/Swiss-Prot:P9WN03"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46621.1"
/translation="MPSRRKSPQFGHEMGAFTSARAREVLVALGQLAAAVVVAVGVAV
VSLLAIARVEWPAFPSSNQLHALTTVGQVGCLAGLVGIGWLWRHGRFRRLARLGGLVL
VSAFTVVTLGMPLGATKLYLFGISVDQQFRTEYLTRLTDTAALRDMTYIGLPPFYPPG
WFWIGGRAAALTGTPAWEMFKPWAITSMAIAVAVALVLWWRMIRFEYALLVTVATAAV
MLAYSSPEPYAAMITVLLPPMLVLTWSGLGARDRQGWAAVVGAGVFLGFAATWYTLLV
AYGAFTVVLMALLLAGSRLQSGIKAAVDPLCRLAVVGAIAAAIGSTTWLPYLLRAARD
PVSDTGSAQHYLPADGAALTFPMLQFSLLGAICLLGTLWLVMRARSSAPAGALAIGVL
AVYLWSLLSMLATLARTTLLSFRLQPTLSVLLVAAGAFGFVEAVQALGKRGRGVIPMA
AAIGLAGAIAFSQDIPDVLRPDLTIAYTDTDGYGQRGDRRPPGSEKYYPAIDAAIRRV
TGKRRDRTVVLTADYSFLSYYPYWGFQGLTPHYANPLAQFDKRATQIDSWSGLSTADE
FIAALDKLPWQPPTVFLMRHGAHNSYTLRLAQDVYPNQPNVRRYTVDLRTALFADPRF
VVEDIGPFVLAIRKPQESA"
gene 4239863..4243147
/gene="embC"
/locus_tag="Rv3793"
CDS 4239863..4243147
/codon_start=1
/transl_table=11
/gene="embC"
/locus_tag="Rv3793"
/product="Integral membrane indolylacetylinositol
arabinosyltransferase EmbC
(arabinosylindolylacetylinositol synthase)"
/note="Rv3793, (MTCY13D12.27), len: 1094 aa. EmbC,
integral membrane protein, indolylacetylinositol
arabinosyltransferase (see citations below), equivalent to
Q9CDA7|EMBC|ML0106 putative arabinosyl transferase from
Mycobacterium leprae (1070 aa) FASTA scores: opt:
6078,E(): 0, (82.95% identity in 1072 aa overlap);
Q50393|EMBC putative arabinosyl transferase from
Mycobacterium smegmatis (1074 aa), FASTA scores: opt:
5523, E(): 0,(75.35% identity in 1072 aa overlap). Also
similar to Q9CDA9|EMBB| ML0104 putative arabinosyl
transferase from Mycobacterium leprae (1083 aa), FASTA
scores: opt: 2789,E(): 1.9e-156, (44.0% identity in 1095
aa overlap); O30406|EMBB putative arabinosyl transferase
from Mycobacterium smegmatis (1082 aa), FASTA scores: opt:
2746,E(): 6.4e-154, (44.6% identity in 1096 aa overlap);
etc. Also similar to to P72030|EMBB|Rv3795|MTCY13D12.29
indolylacetylinositol arabinosyltransferase from
Mycobacterium tuberculosis (1098 aa), FASTA scores: opt:
2276, E(): 3.1e-126, (44.45% identity in 1118 aa overlap);
and P72060|EMBA|Rv3794|MTCY13D12.28 indolylacetylinositol
arabinosyltransferase from Mycobacterium tuberculosis
(1094 aa), FASTA scores: opt: 1974, E(): 1.9e-108, (41.0%
identity in 1110 aa overlap). Contains PS00044 Bacterial
regulatory proteins, lysR family signature; and PS00017
ATP/GTP-binding site motif A (P-loop). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3793"
/db_xref="EnsemblGenomes-Tr:CCP46622"
/db_xref="GOA:P9WNL5"
/db_xref="InterPro:IPR007680"
/db_xref="InterPro:IPR027451"
/db_xref="InterPro:IPR032731"
/db_xref="InterPro:IPR040920"
/db_xref="InterPro:IPR042486"
/db_xref="PDB:3PTY"
/db_xref="UniProtKB/Swiss-Prot:P9WNL5"
/inference="protein motif:PROSITE:PS00044"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46622.1"
/translation="MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLA
IATPLLPVNQTTAQLNWPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGK
TVLLSTVPKQAPKAVDRGLLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAH
ADRVAAEFVGLVQGPNAEHPGAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASV
DTRYSSSPTPLKMAAMILGVALTGAALVALHILDTADGMRHRRFLPARWWSTGGLDTL
VIAVLVWWHFVGANTSDDGYILTMARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALW
AHVSTASIWMRLPTLAMALTCWWVISREVIPRLGHAVKTSRAAAWTAAGMFLAVWLPL
DNGLRPEPIIALGILLTWCSVERAVATSRLLPVAIACIIGALTLFSGPTGIASIGALL
VAIGPLRTILHRRSRRFGVLPLVAPILAAATVTAIPIFRDQTFAGEIQANLLKRAVGP
SLKWFDEHIRYERLFMASPDGSIARRFAVLALVLALAVSVAMSLRKGRIPGTAAGPSR
RIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSLGALAAVAVTGAAMRSRRNRTVFAA
VVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWSLTTALLELTVLVLLLAAWFHFV
ANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEVVSLTQAMISQYPAWSVGRSN
LQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAGLSEAFTPNGIPADVTADP
VMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLPYNLDPARTPVLGSWRA
GVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQWATDEQAAAGHHGGS
MEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIALTPPRIPRVRTLQ
NVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEANSPVMDHNGG
GPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTVTRSGLWSP
APLRRG"
gene 4243233..4246517
/gene="embA"
/locus_tag="Rv3794"
CDS 4243233..4246517
/codon_start=1
/transl_table=11
/gene="embA"
/locus_tag="Rv3794"
/product="Integral membrane indolylacetylinositol
arabinosyltransferase EmbA
(arabinosylindolylacetylinositol synthase)"
/note="Rv3794, (MTCY13D12.28), len: 1094 aa. EmbA,
integral membrane protein, indolylacetylinositol
arabinosyltransferase (see citations below), equivalent to
P71485|EMBA arabinosyl transferase from Mycobacterium
avium (1108 aa), FASTA scores: opt: 5024, E(): 0, (81.9%
identity in 1109 aa overlap); Q9CDA8|EMBA|ML0105 putative
arabinosyl transferase from Mycobacterium leprae (1111
aa), FASTA scores: opt: 4782, E(): 0, (78.6% identity in
1111 aa overlap); Q50394|EMBA putative arabinosyl
transferase from Mycobacterium smegmatis (1092 aa), FASTA
scores: opt: 4100,E(): 0, (67.4% identity in 1092 aa
overlap). Also similar to Q9CDA7|EMBC|ML0106 putative
arabinosyl transferase from Mycobacterium leprae (1070
aa), FASTA scores: opt: 1933,E(): 1.5e-100, (40.6%
identity in 1108 aa overlap); Q50393|EMBC putative
arabinosyl transferase from Mycobacterium smegmatis (1074
aa), FASTA scores: opt: 1870,E(): 5.1e-97, (41.4% identity
in 1113 aa overlap); etc. Also similar to
P72059|EMBC|Rv3793|MTCY13D12.27 indolylacetylinositol
arabinosyltransferase from Mycobacterium tuberculosis
(1094 aa), FASTA scores: opt: 1974, E(): 7.7e-103, (40.9%
identity in 1110 aa overlap); and
P72030|EMBB|Rv3795|MTCY13D12.29 indolylacetylinositol
arabinosyltransferase from Mycobacterium tuberculosis
(1098 aa), FASTA scores: opt: 1288, E(): 2.1e-64, (42.5%
identity in 1114 aa overlap). Supposedly regulated by
embR|Rv1267c. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3794"
/db_xref="EnsemblGenomes-Tr:CCP46623"
/db_xref="GOA:P9WNL9"
/db_xref="InterPro:IPR007680"
/db_xref="InterPro:IPR027451"
/db_xref="InterPro:IPR032731"
/db_xref="InterPro:IPR040920"
/db_xref="InterPro:IPR042486"
/db_xref="UniProtKB/Swiss-Prot:P9WNL9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46623.1"
/translation="MPHDGNERSHRIARLAAVVSGIAGLLLCGIVPLLPVNQTTATIF
WPQGSTADGNITQITAPLVSGAPRALDISIPCSAIATLPANGGLVLSTLPAGGVDTGK
AGLFVRANQDTVVVAFRDSVAAVAARSTIAAGGCSALHIWADTGGAGADFMGIPGGAG
TLPPEKKPQVGGIFTDLKVGAQPGLSARVDIDTRFITTPGALKKAVMLLGVLAVLVAM
VGLAALDRLSRGRTLRDWLTRYRPRVRVGFASRLADAAVIATLLLWHVIGATSSDDGY
LLTVARVAPKAGYVANYYRYFGTTEAPFDWYTSVLAQLAAVSTAGVWMRLPATLAGIA
CWLIVSRFVLRRLGPGPGGLASNRVAVFTAGAVFLSAWLPFNNGLRPEPLIALGVLVT
WVLVERSIALGRLAPAAVAIIVATLTATLAPQGLIALAPLLTGARAIAQRIRRRRATD
GLLAPLAVLAAALSLITVVVFRDQTLATVAESARIKYKVGPTIAWYQDFLRYYFLTVE
SNVEGSMSRRFAVLVLLFCLFGVLFVLLRRGRVAGLASGPAWRLIGTTAVGLLLLTFT
PTKWAVQFGAFAGLAGVLGAVTAFTFARIGLHSRRNLTLYVTALLFVLAWATSGINGW
FYVGNYGVPWYDIQPVIASHPVTSMFLTLSILTGLLAAWYHFRMDYAGHTEVKDNRRN
RILASTPLLVVAVIMVAGEVGSMAKAAVFRYPLYTTAKANLTALSTGLSSCAMADDVL
AEPDPNAGMLQPVPGQAFGPDGPLGGISPVGFKPEGVGEDLKSDPVVSKPGLVNSDAS
PNKPNAAITDSAGTAGGKGPVGINGSHAALPFGLDPARTPVMGSYGENNLAATATSAW
YQLPPRSPDRPLVVVSAAGAIWSYKEDGDFIYGQSLKLQWGVTGPDGRIQPLGQVFPI
DIGPQPAWRNLRFPLAWAPPEADVARIVAYDPNLSPEQWFAFTPPRVPVLESLQRLIG
SATPVLMDIATAANFPCQRPFSEHLGIAELPQYRILPDHKQTAASSNLWQSSSTGGPF
LFTQALLRTSTIATYLRGDWYRDWGSVEQYHRLVPADQAPDAVVEEGVITVPGWGRPG
PIRALP"
gene 4246514..4249810
/gene="embB"
/locus_tag="Rv3795"
CDS 4246514..4249810
/codon_start=1
/transl_table=11
/gene="embB"
/locus_tag="Rv3795"
/product="Integral membrane indolylacetylinositol
arabinosyltransferase EmbB
(arabinosylindolylacetylinositol synthase)"
/note="Rv3795, (MTCY13D12.29), len: 1098 aa. EmbB,
integral membrane protein, indolylacetylinositol
arabinosyltransferase (see citations below), equivalent to
P71486|EMBB arabinosyl transferase from Mycobacterium
avium (1065 aa), FASTA scores: opt: 4998, E(): 0, (83.25%
identity in 1076 aa overlap); Q9CDA9|EMBB|ML0104 putative
arabinosyl transferase from Mycobacterium leprae (1083
aa),FASTA scores: opt: 4706, E(): 0, (78.0% identity in
1101 aa overlap); O30406|EMBB (alias Q50395) putative
arabinosyl transferase from Mycobacterium smegmatis (1082
aa), FASTA scores: opt: 4163, E(): 0, (68.4% identity in
1091 aa overlap); etc. Also similar to Q50393|EMBC
putative arabinosyl transferase from Mycobacterium
smegmatis (1074 aa), FASTA scores: opt: 2482, E(): 5e-135,
(44.7% identity in 1101 aa overlap); Q9CDA7|EMBC|ML0106
putative arabinosyl transferase from Mycobacterium leprae
(1070 aa), FASTA scores: opt: 2259, E(): 3.4e-122, (43.4%
identity in 1104 aa overlap); etc. Also similar to
P72059|EMBC|Rv3793|MTCY13D12.27 indolylacetylinositol
arabinosyltransferase from Mycobacterium tuberculosis
(1094 aa), FASTA scores: opt: 2276, E(): 3.6e-123, (44.45%
identity in 1118 aa overlap); and
P72060|EMBA|Rv3794|MTCY13D12.28 indolylacetylinositol
arabinosyltransferase from Mycobacterium tuberculosis
(1094 aa), FASTA scores: opt: 1288, E(): 2.5e-66, (42.35%
identity in 1114 aa overlap). Supposedly regulated by
embR|Rv1267c. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3795"
/db_xref="EnsemblGenomes-Tr:CCP46624"
/db_xref="GOA:P9WNL7"
/db_xref="InterPro:IPR007680"
/db_xref="InterPro:IPR027451"
/db_xref="InterPro:IPR032731"
/db_xref="InterPro:IPR040920"
/db_xref="InterPro:IPR042486"
/db_xref="UniProtKB/Swiss-Prot:P9WNL7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46624.1"
/translation="MTQCASRRKSTPNRAILGAFASARGTRWVATIAGLIGFVLSVAT
PLLPVVQTTAMLDWPQRGQLGSVTAPLISLTPVDFTATVPCDVVRAMPPAGGVVLGTA
PKQGKDANLQALFVVVSAQRVDVTDRNVVILSVPREQVTSPQCQRIEVTSTHAGTFAN
FVGLKDPSGAPLRSGFPDPNLRPQIVGVFTDLTGPAPPGLAVSATIDTRFSTRPTTLK
LLAIIGAIVATVVALIALWRLDQLDGRGSIAQLLLRPFRPASSPGGMRRLIPASWRTF
TLTDAVVIFGFLLWHVIGANSSDDGYILGMARVADHAGYMSNYFRWFGSPEDPFGWYY
NLLALMTHVSDASLWMRLPDLAAGLVCWLLLSREVLPRLGPAVEASKPAYWAAAMVLL
TAWMPFNNGLRPEGIIALGSLVTYVLIERSMRYSRLTPAALAVVTAAFTLGVQPTGLI
AVAALVAGGRPMLRILVRRHRLVGTLPLVSPMLAAGTVILTVVFADQTLSTVLEATRV
RAKIGPSQAWYTENLRYYYLILPTVDGSLSRRFGFLITALCLFTAVFIMLRRKRIPSV
ARGPAWRLMGVIFGTMFFLMFTPTKWVHHFGLFAAVGAAMAALTTVLVSPSVLRWSRN
RMAFLAALFFLLALCWATTNGWWYVSSYGVPFNSAMPKIDGITVSTIFFALFAIAAGY
AAWLHFAPRGAGEGRLIRALTTAPVPIVAGFMAAVFVASMVAGIVRQYPTYSNGWSNV
RAFVGGCGLADDVLVEPDTNAGFMKPLDGDSGSWGPLGPLGGVNPVGFTPNGVPEHTV
AEAIVMKPNQPGTDYDWDAPTKLTSPGINGSTVPLPYGLDPARVPLAGTYTTGAQQQS
TLVSAWYLLPKPDDGHPLVVVTAAGKIAGNSVLHGYTPGQTVVLEYAMPGPGALVPAG
RMVPDDLYGEQPKAWRNLRFARAKMPADAVAVRVVAEDLSLTPEDWIAVTPPRVPDLR
SLQEYVGSTQPVLLDWAVGLAFPCQQPMLHANGIAEIPKFRITPDYSAKKLDTDTWED
GTNGGLLGITDLLLRAHVMATYLSRDWARDWGSLRKFDTLVDAPPAQLELGTATRSGL
WSPGKIRIGP"
gene 4249878..4251005
/gene_synonym="atsH"
/locus_tag="Rv3796"
CDS 4249878..4251005
/codon_start=1
/transl_table=11
/gene_synonym="atsH"
/locus_tag="Rv3796"
/product="Conserved protein"
/note="Rv3796, (MTV026.01-MTCY13D12.30), len: 375 aa.
Conserved protein. C-terminal end similar in part to
Q983J3|MLR8305 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (227 aa), FASTA scores: opt: 288,
E(): 4e-09, (38.95% identity in 154 aa overlap). Similar
to P54548|YQJK_BACSU hypothetical protein (belongs to the
ATSA/ELAC family) from Bacillus subtilis (307 aa) FASTA
scores: opt: 263, E(): 1.3e-07, (26.1% identity in 295 aa
overlap); and some similarity to other proteins e.g.
AAK46775|MT2479 putative arylsulfatase from Mycobacterium
tuberculosis strain CDC1551 (224 aa), FASTA scores: opt:
194, E(): 0.00072, (25.85% identity in 259 aa overlap).
Equivalent to AAK48269 from Mycobacterium tuberculosis
strain CDC1551 (338 aa) but longer 37 aa. Some similarity
to the A. carrageenovora AtsA / E. coli ElaC family. Note
that previously known as atsH. Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3796"
/db_xref="EnsemblGenomes-Tr:CCP46625"
/db_xref="GOA:P72062"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/TrEMBL:P72062"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46625.1"
/translation="MLLGMHQAGHVGTHERRAAATRRSALTAAGLAVVGAGVLGASAC
SPQKSPQPSSPRLPDNALITLGVAAGPPPTPSRVGISSVLKIGRDLYVIDCGLGSLNA
FTNAGLQFDDLKAMFITHLHTDHIVDYYNFFLSGGFLAPPGRAPVLVYGPGPAGGLPP
SEVGNPNPATVNPANPTPGLAAATEALHRAFAYTSNIFIRDYGIDNVADLVKVTEIGL
PPGSDYRNRAPKMSPFSVASDDNVSVTATLVSHYDVYPAFGFRFDLKKSGVSVTFSGD
TTKSDNLITLAQGTDILVHEAVFSLDTAYFGNAFPPNYLVNSHTSAEQVGEVAAAAKP
KQLILSHYAPDDLPDSQWLDKIKKNYSGMTTIARDGQVFAL"
gene 4251085..4252866
/gene="fadE35"
/locus_tag="Rv3797"
CDS 4251085..4252866
/codon_start=1
/transl_table=11
/gene="fadE35"
/locus_tag="Rv3797"
/product="Probable acyl-CoA dehydrogenase FadE35"
/note="Rv3797, (MTV026.02), len: 593 aa. Probable
fadE35,acyl-CoA dehydrogenase, similar to many e.g.
Q9HY33|PA3593 from Pseudomonas aeruginosa (575 aa) FASTA
scores: opt: 838, E(): 2.1e-46, (35.3% identity in 569 aa
overlap); Q9ANZ8|AIDB from Burkholderia pseudomallei
(Pseudomonas pseudomallei) (554 aa), FASTA scores: opt:
633, E(): 3.4e-33, (33.1% identity in 480 aa overlap);
Q9HX44|PA3972 from Pseudomonas aeruginosa (549 aa) FASTA
scores: opt: 560, E(): 1.7e-28, (29.9% identity in 569 aa
overlap); P33224|AIDB_ECOLI|B4187 from Escherichia coli
strain K12 (541 aa), FASTA scores: opt: 455, E(): 1e-21,
(31.15% identity in 514 aa overlap); etc. Also similar to
O86368|FADE8|Rv0672|MTCI376.02c acyl-CoA dehydrogenase
from Mycobacterium tuberculosis (542 aa), FASTA scores:
opt: 479, E(): 2.9e-23, (32.2% identity in 460 aa
overlap). Could belong to the acyl-CoA dehydrogenases
family."
/db_xref="EnsemblGenomes-Gn:Rv3797"
/db_xref="EnsemblGenomes-Tr:CCP46626"
/db_xref="GOA:O53577"
/db_xref="InterPro:IPR006091"
/db_xref="InterPro:IPR009075"
/db_xref="InterPro:IPR009100"
/db_xref="InterPro:IPR034184"
/db_xref="InterPro:IPR036250"
/db_xref="InterPro:IPR041504"
/db_xref="UniProtKB/TrEMBL:O53577"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46626.1"
/translation="MPEYDLEAVDKLPFSTPEKAQRYQTENYRGAMGLNWYLTDPTLQ
FIMAYYLRPDELAFAEPHLTRIGELTGGPVTRWAEETDRNPPRLERYDRWGHDISRVV
LPESFIQSKRAVIEARQAVRDDAARAGVKPSLALFAADYLLNQADIGMACALATGGNM
VRSLVTAYAPPDVREFVLGKLNSGEWDGEAAQLLTERAGGSDLGALETTATRSGDVWL
LNGFKWFASNCAGEAFVVLAKPEGAPDSTRGVATFLVLRTRRDGSRNGVRIRRLKDKL
GTRSVASGEIEFVDAEAFLLSGEPSADAGPSDGKGLTRMMELTNRLRLGTASFALGNA
RRALVESLCYAGQRRAFGGALIDKPLMRRKLAEMVVDVEAALAMVFDGFGAANHRQPR
CLPQRIAVPVTKLKTCRLGITVASDAIEIHGGNGYIETWPVARLLRDAQVNTIWEGPD
NILCLDVRRGIEQTRAHETLLARLRDAVSVSDDDDTTRLVSRRIEDLDAAITAWTKLD
RQLAEARLFPLAQFMGDVYAGALLTEQAAWERATRGTDRKALVARLYARRYLADQGPL
RGIDADCDEALQRFDELVAGAFTAEQT"
gene 4252993..4254327
/locus_tag="Rv3798"
CDS 4252993..4254327
/codon_start=1
/transl_table=11
/locus_tag="Rv3798"
/product="Probable transposase"
/note="Rv3798, (MTV026.03), len: 444 aa. Probable
transposase for insertion sequence element IS1557, highly
similar to Q60255 similar to transposase of ISAE1 from
alcaligenes eutrophus H1-4 (fragment) from
dibenzofuran-degrading bacterium DPO360 (163 aa) FASTA
scores: opt: 767, E(): 3.2e-42, (67.25% identity in 168 aa
overlap); and similar to P74920 transposase from
Thiobacillus ferrooxidans (404 aa), FASTA scores: opt:
375,E(): 1.1e-16, (27.55% identity in 439 aa overlap);
Q48349 transposase from Alcaligenes eutrophus (Ralstonia
eutropha) (408 aa), FASTA scores: opt: 324, E(): 2e-13,
(3.9% identity in 369 aa overlap); Q9FDC1|TNP transposase
from Burkholderia mallei (Pseudomonas mallei) (386 aa)
FASTA scores: opt: 282, E(): 9.8e-11, (25.85% identity in
391 aa overlap); etc. C-terminal end identical to
O53804|Rv0741|MTV041.15 transposase from Mycobacterium
tuberculosis (104 aa), FASTA scores: opt: 582, E():
1.8e-30, (85.6% identity in 104 aa overlap). Belongs to
the transposase family 12."
/db_xref="EnsemblGenomes-Gn:Rv3798"
/db_xref="EnsemblGenomes-Tr:CCP46627"
/db_xref="GOA:P9WKH7"
/db_xref="InterPro:IPR002560"
/db_xref="InterPro:IPR029261"
/db_xref="InterPro:IPR032877"
/db_xref="UniProtKB/Swiss-Prot:P9WKH7"
/protein_id="CCP46627.1"
/translation="MRNVRLFRALLGVDKRTVIEDIEFEEDDAGDGARVIARVRPRSA
VLRRCGRCGRKASWYDRGAGLRQWRSLDWGTVEVFLEAEAPRVNCPTHGPTVVAVPWA
RHHAGHTYAFDDTVAWLAVACSKTAVCELMRIAWRTVGAIVARVWADTEKRIDRFANL
RRIGIDEISYKRHHRYLTVVVDHDSGRLVWAAPGHDKATLGLFFDALGAERAAQITHV
SADAADWIADVVTERCPDAIQCADPFHVVAWATEALDVERRRAWNDARAIARTEPKWG
RGRPGKNAAPRPGRERARRLKGARYALWKNPEDLTERQSAKLAWIAKTDPRLYRAYLL
KESLRHVFSVKGEEGKQALDRWISWAQRCRIPVFVELAARIKRHRVAIDAALDHGLSQ
GLIESTNTKIRLLTRIAFGFRSPQALIALAMLTLAGHRPTLPGRHNHPQISQ"
mobile_element 4252993..4254324
/mobile_element_type="insertion sequence:IS1557-3"
/locus_tag="Rv3798"
/note="IS1557-3, len: 1332 nt. Insertion sequence IS1557."
gene complement(4254380..4255948)
/gene="accD4"
/locus_tag="Rv3799c"
CDS complement(4254380..4255948)
/codon_start=1
/transl_table=11
/gene="accD4"
/locus_tag="Rv3799c"
/product="Probable propionyl-CoA carboxylase beta chain 4
AccD4 (pccase) (propanoyl-CoA:carbon dioxide ligase)"
/note="Rv3799c, (MTV026.04c), len: 522 aa. Probable
accD4,propionyl-CoA carboxylase beta chain 4, equivalent
to Q9CDB0|ACCD4|ML0102 putative acyl CoA carboxylase from
Mycobacterium leprae (517 aa) FASTA scores: opt: 3154,
E(): 8e-187, (91.2% identity in 511 aa overlap). Also
similar to many e.g. Q9X4K7|PCCB from Streptomyces
coelicolor (530 aa), FASTA scores: opt: 1714, E():
4.4e-98, (50.0% identity in 510 aa overlap);
P53003|PCCB_SACER from Saccharopolyspora erythraea
(Streptomyces erythraeus) (546 aa), FASTA scores: opt:
1549, E(): 6.6e-88, (50.65% identity in 519 aa overlap);
Q9WZH5|TM0716 from Thermotoga maritima (515 aa) FASTA
scores: opt: 1529, E(): 1.1e-86,(46.7% identity in 512 aa
overlap); etc. Also similar to
P53002|PCCB_MYCLE|ACCD5|PCCB|ML0731|B1308_C1_125 probable
propionyl-CoA carboxylase beta chain 5 from Mycobacterium
leprae (549 aa), FASTA scores: opt: 1493, E():
1.9e-84,(49.8% identity in 514 aa overlap); and
P96885|PCC5_MYCTU|ACCD5|PCCB|Rv3280|MT3379.1|MTCY71.20
probable propionyl-CoA carboxylase beta chain 5 from
Mycobacterium tuberculosis (548 aa), FASTA scores: opt:
1471, E(): 4.2e-83, (49.15% identity in 515 aa overlap).
Belongs to the ACCD/PCCB family. Length extended since
first submission (+5 aa). AccA3 (Rv3285), AccD5
(Rv3280),AccD4 (Rv3799), and AccE5 (Rv3281) form a
biotin-dependent acyl-CoA carboxylase in M. tuberculosis
H37Rv (See Oh et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv3799c"
/db_xref="EnsemblGenomes-Tr:CCP46628"
/db_xref="GOA:O53578"
/db_xref="InterPro:IPR011762"
/db_xref="InterPro:IPR011763"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR034733"
/db_xref="UniProtKB/TrEMBL:O53578"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46628.1"
/translation="MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPS
ARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSHDQTVFG
GTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSG
LVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGG
ADHQASYGNIHQVVESEAAAYQYVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELD
SIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMH
MSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAV
VEADVPKVTITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLMKRFP
DPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDAVIDPHETRLLLRKSMHLLRDKQ
LWWRVGRKHGLIPV"
gene complement(4255945..4261146)
/gene="pks13"
/locus_tag="Rv3800c"
CDS complement(4255945..4261146)
/codon_start=1
/transl_table=11
/gene="pks13"
/locus_tag="Rv3800c"
/product="Polyketide synthase Pks13"
/note="Rv3800c, (MTV026.05c), len: 1733 aa. Probable
pks13,polyketide synthase, equivalent to
Q9CDB1|PKS13|ML0101 polyketide synthase from Mycobacterium
leprae (1784 aa),FASTA scores: opt: 7454, E(): 0, (83.6%
identity in 1748 aa overlap); and similar to
Q9Z5K6|ML2357|MLCB12.02c putative polyketide synthase from
Mycobacterium leprae (1871 aa),FASTA scores: opt: 1682,
E(): 1.2e-85, (38.3% identity in 1096 aa overlap). Also
similar in part to many e.g. Q9ADL6|SORA soraphen
polyketide synthase a from Polyangium cellulosum (6315 aa)
FASTA scores: opt: 1422, E(): 1e-70,(31.45% identity in
1616 aa overlap); AAK73501|AMPHI AMPHI protein (involved
in amphotericin biosynthesis) from Streptomyces nodosus
(9510 aa), FASTA scores: opt: 1441,E(): 1.2e-71, (30.45%
identity in 1662 aa overlap); Q9RFL0|MTAB MTAB protein
(involved in myxothiazol biosynthesis) from Stigmatella
aurantiaca (4003 aa), FASTA scores: opt: 1429, E():
2.8e-71, (33.8% identity in 1089 aa overlap); Q9L4X2|NYSJ
from Streptomyces noursei (5435 aa),FASTA scores: opt:
1407, E(): 6.1e-70, (30.5% identity in 1764 aa overlap);
CAC37876|SC1G7.01c from Streptomyces coelicolor (3489 aa)
FASTA scores: opt: 1382, E(): 1e-68,(31.05% identity in
1489 aa overlap); etc. Also highly similar to
Q10977|PPSA_MYCTU|Rv2931|MT3000|MTCY338.20
phenolpthiocerol synthesis polyketide synthase from
Mycobacterium tuberculosis (1876 aa), FASTA scores: opt:
1728, E(): 3.4e-88, (36.95% identity in 1269 aa overlap);
and P96203|PPSD|Rv2934|MTCY19H9.02. Contains PS00606
Beta-ketoacyl synthases active site."
/db_xref="EnsemblGenomes-Gn:Rv3800c"
/db_xref="EnsemblGenomes-Tr:CCP46629"
/db_xref="GOA:I6X8D2"
/db_xref="InterPro:IPR001031"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036736"
/db_xref="PDB:5V3W"
/db_xref="PDB:5V3X"
/db_xref="PDB:5V3Y"
/db_xref="PDB:5V3Z"
/db_xref="PDB:5V40"
/db_xref="PDB:5V41"
/db_xref="PDB:5V42"
/db_xref="PDB:5XUO"
/db_xref="PDB:6C4Q"
/db_xref="PDB:6C4V"
/db_xref="PDB:6D8I"
/db_xref="PDB:6D8J"
/db_xref="UniProtKB/TrEMBL:I6X8D2"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46629.1"
/translation="MADVAESQENAPAERAELTVPEMRQWLRNWVGKAVGKAPDSIDE
SVPMVELGLSSRDAVAMAADIEDLTGVTLSVAVAFAHPTIESLATRIIEGEPETDLAG
DDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQALLEGRDGITDLPDGRWSEF
LEEPRLAARVAGARTRGGYLKDIKGFDSEFFAVAKTEADNIDPQQRMALELTWEALEH
ARIPASSLRGQAVGVYIGSSTNDYSFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDF
HGPSVTIDTACSSSLVAIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLA
PDGRIKSFSADADGYTRSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLI
APNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTILGDPIEAEALGRVVGRGRPADR
PALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSINFAGPSPYIDFDAMRLKMI
TTPTDWPRYGGYALAGVSSFGFGGANAHVVVREVLPRDVVEKEPEPEPEPKAAAEPAE
APTLAGHALRFDEFGNIITDSAVAEEPEPELPGVTEEALRLKEAALEELAAQEVTAPL
VPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDH
DEAIKGLRAVAAGKQAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAW
IEKVDALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKPAAVI
GQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIR
EVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFATKGASHTSQMD
PLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPIHDVEYWKKGLRHSVYFTHG
IRNAVDSGHTTFLELAPNPVALMQVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMA
QLYVYGHDLDIRTLFSRASGPQDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVAL
PDGRHVWEYAPRDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVTTMTRHP
GGASVQVHARIDESFTLVYDALVSRAGSESVLPTAVGAATAIAVADGAPVAPETPAED
ADAETLSDSLTTRYMPSGMTRWSPDSGETIAERLGLIVGSAMGYEPEDLPWEVPLIEL
GLDSLMAVRIKNRVEYDFDLPPIQLTAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQK
TQTAEEIARAQAELLHGKVGKTEPVDSEAGVALPSPQNGEQPNPTGPALNVDVPPRDA
AERVTFATWAIVTGKSPGGIFNELPRLDDEAAAKIAQRLSERAEGPITAEDVLTSSNI
EALADKVRTYLEAGQIDGFVRTLRARPEAGGKVPVFVFHPAGGSTVVYEPLLGRLPAD
TPMYGFERVEGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLGKD
VRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVTIPAIPYEQLEELDDEGQ
VRFVLDAVSQSGVQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGHVTLYMADRYHDDAI
MFEPRYAVRQPDGGWGEYVSDLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADR
TSEVGKQ"
gene complement(4261153..4263066)
/gene="fadD32"
/locus_tag="Rv3801c"
CDS complement(4261153..4263066)
/codon_start=1
/transl_table=11
/gene="fadD32"
/locus_tag="Rv3801c"
/product="Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP
synthetase) (fatty-acid-AMP synthase). Also shown to have
acyl-ACP ligase activity."
/note="Rv3801c, (MTV026.06c), len: 637 aa.
FadD32,fatty-acid-AMP synthetase, equivalent to
Q9CDB2|FADD32|ML0100 putative acyl-CoA synthetase from
Mycobacterium leprae (635 aa), FASTA scores: opt:
3892,E(): 0, (93.05% identity in 632 aa overlap); and
highly similar to others from Mycobacterium leprae. Also
similar to others from Mycobacterium tuberculosis e.g.
P95288|FADD31|Rv1925|MTCY09F9.39c (620 aa), FASTA scores:
opt: 1567, E(): 1.7e-88, (47.05% identity in 612 aa
overlap); MTCY338_18, MTCY349_40, MTV005_21,
MTCY24G1_8,MTCY19G5_7, MTCY4D9_17; and MBU75685_1 acyl-CoA
ligase from Mycobacterium bovis."
/db_xref="EnsemblGenomes-Gn:Rv3801c"
/db_xref="EnsemblGenomes-Tr:CCP46630"
/db_xref="GOA:O53580"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="PDB:5HM3"
/db_xref="UniProtKB/Swiss-Prot:O53580"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46630.1"
/translation="MFVTGESGMAYHNPFIVNGKIRFPANTNLVRHVEKWAKVRGDKL
AYRFLDFSTERDGVARDILWSDFSARNRAVGARLQQVTQPGDRVAILCPQNLDYLISF
FGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCAPSTILTTTDSAEGVRKFIRARSAKE
RPRVIAVDAVPTEVAATWQQPEANEETVAYLQYTSGSTRIPSGVQITHLNLPTNVVQV
LNALEGQEGDRGVSWLPFFHDMGLITVLLASVLGHSFTFMTPAAFVRRPGRWIRELAR
KPGETGGTFSAAPNFAFEHAAVRGVPRDDEPPLDLSNVKGILNGSEPVSPASMRKFFE
AFAPYGLKQTAVKPSYGLAEATLFVSTTPMDEVPTVIHVDRDELNNQRFVEVAADAPN
AVAQVSAGKVGVSEWAVIVDADTASELPDGQIGEIWLHGNNLGTGYWGKEEESAQTFK
NILKSRISESRAEGAPDDALWVRTGDYGTYFKDHLYIAGRIKDLVIIDGRNHYPQDLE
CTAQESTKALRVGYAAAFSVPANQLPQTVFDDSHAGLKFDPEDTSEQLVIVGERAAGT
HKLDHQPIVDDIRAAIAVGHGVTVRDVLLVSAGTIPRTSSGKIGRRACRAAYLDGSLR
SGVGSPTVFATSD"
gene complement(4263355..4264365)
/gene_synonym="clp6"
/gene_synonym="culp6"
/locus_tag="Rv3802c"
CDS complement(4263355..4264365)
/codon_start=1
/transl_table=11
/gene_synonym="clp6"
/gene_synonym="culp6"
/locus_tag="Rv3802c"
/product="Probable conserved membrane protein"
/note="Rv3802c, (MTV026.07c), len: 336 aa. Probable
conserved membrane protein, with a N-terminal signal
sequence followed by Pro-rich region. Equivalent to
Q9CDB3|ML0099 hypothetical protein from Mycobacterium
leprae (336 aa) FASTA scores: opt: 1759, E():
1.1e-85,(75.5% identity in 335 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004). Predicted to be an outer
membrane protein (See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3802c"
/db_xref="EnsemblGenomes-Tr:CCP46631"
/db_xref="GOA:O53581"
/db_xref="InterPro:IPR000675"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:5W95"
/db_xref="UniProtKB/TrEMBL:O53581"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46631.1"
/translation="MAKNSRRKRHRILAWIAAGAMASVVALVIVAVVIMLRGAESPPS
AVPPGVLPPGPTPAHPHKPRPAFQDASCPDVQMISVPGTWESSPQQNPLNPVQFPKAL
LLKVTGPIAQQFAPARVQTYTVAYTAQFHNPLTTDNQMSYNDSRAEGTRAMVAAMTDM
NNRCPLTSYVLIGFSQGAVIAGDVASDIGNGRGPVDEDLVLGVTLIADGRRQQGVGNQ
VPPSPRGEGAEITLHEVPVLSGLGLTMTGPRPGGFGALDGRTNEICAQGDLICAAPAQ
AFSPANLPTTLNTLAGGAGQPVHAMYATPEFWNSDGEPATEWTLNWAHQLIENAPHPK
HR"
gene complement(4264563..4265462)
/gene="fbpD"
/gene_synonym="fbpC1"
/gene_synonym="mpb51"
/gene_synonym="mpt51"
/locus_tag="Rv3803c"
CDS complement(4264563..4265462)
/codon_start=1
/transl_table=11
/gene="fbpD"
/gene_synonym="fbpC1"
/gene_synonym="mpb51"
/gene_synonym="mpt51"
/locus_tag="Rv3803c"
/product="Secreted MPT51/MPB51 antigen protein FbpD
(MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl
transferase 85C) (fibronectin-binding protein C) (85C)"
/note="Rv3803c, (MT3910, MTV026.08c), len: 299 aa. FbpD
(alternate gene names: mpt51, mpb51, fbpC1), secreted
MPB51/MPT51 antigen protein (fibronectin-binding protein
C) (mycolyl transferase 85C) (see citations below),
identical to Q48923|MPT51|MPB51 antigen precursor from
Mycobacterium bovis (299 aa), FASTA scores: opt: 2093,
E(): 1.5e-112,(100.0% identity in 299 aa overlap) (see
Ohara et al.,1995); and highly similar to other
Mycobacterial antigen precursors e.g.
Q05868|MPT5_MYCLE|MPT51|ML0098 MPT51 antigen precursor
from Mycobacterium leprae (301 aa), FASTA scores: opt:
1624, E(): 9.8e-86, (77.8% identity in 302 aa overlap);
O52972|A85C_MYCAV|FBPC antigen 85-C precursor
(fibronectin-binding protein C) from Mycobacterium avium
(352 aa), FASTA scores: opt: 753, E(): 6.6e-36, (41.5%
identity in 315 aa overlap); P21160|A85B_MYCKA antigen
85-B precursor (fibronectin-binding protein B) from
Mycobacterium kansasii (325 aa), FASTA scores: opt:
574,E(): 1.1e-25, (37.55% identity in 309 aa overlap);
P12942|A85B_MYCBO antigen 85-B precursor from
Mycobacterium bovis (323 aa), FASTA scores: opt: 572, E():
1.4e-25,(39.85% identity in 291 aa overlap); etc. Also
similar to P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|
FBPC2 secreted antigen 85-C (mycolyl transferase 85C)
(fibronectin-binding protein C) from Mycobacterium
tuberculosis (340 aa), FASTA scores: opt: 751, E():
8.4e-36, (40.65% identity in 310 aa overlap);
P17944|A85A_MYCTU|FBPA|MPT44|Rv3804c|MT3911|MTV026.09c
secreted antigen 85-a (mycolyl transferase 85A)
(fibronectin-binding protein A) from Mycobacterium
tuberculosis (338 aa), FASTA scores: opt: 592, E():
1e-26,(39.05% identity in 302 aa overlap); etc. Contains
PS00178 Aminoacyl-transfer RNA synthetases class-I
signature. Note that the secreted protein MPB51 is one of
the major proteins in the culture filtrate of
Mycobacterium bovis BCG. Note that overexpression in an
FbpC-deficient M. tuberculosis clinical isolate has no
effect on the amount of cell wall-linked mycolates (See
Puech et al., 2002)."
/db_xref="EnsemblGenomes-Gn:Rv3803c"
/db_xref="EnsemblGenomes-Tr:CCP46632"
/db_xref="GOA:P9WQN7"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:1R88"
/db_xref="UniProtKB/Swiss-Prot:P9WQN7"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46632.1"
/translation="MKGRSALLRALWIAALSFGLGGVAVAAEPTAKAAPYENLMVPSP
SMGRDIPVAFLAGGPHAVYLLDAFNAGPDVSNWVTAGNAMNTLAGKGISVVAPAGGAY
SMYTNWEQDGSKQWDTFLSAELPDWLAANRGLAPGGHAAVGAAQGGYGAMALAAFHPD
RFGFAGSMSGFLYPSNTTTNGAIAAGMQQFGGVDTNGMWGAPQLGRWKWHDPWVHASL
LAQNNTRVWVWSPTNPGASDPAAMIGQAAEAMGNSRMFYNQYRSVGGHNGHFDFPASG
DNGWGSWAPQLGAMSGDIVGAIR"
gene complement(4265642..4266658)
/gene="fbpA"
/gene_synonym="85A"
/gene_synonym="mpt44"
/locus_tag="Rv3804c"
CDS complement(4265642..4266658)
/codon_start=1
/transl_table=11
/gene="fbpA"
/gene_synonym="85A"
/gene_synonym="mpt44"
/locus_tag="Rv3804c"
/product="Secreted antigen 85-a FbpA (mycolyl transferase
85A) (fibronectin-binding protein A) (antigen 85 complex
A)"
/note="Rv3804c, (MT3911, MTV026.09c), len: 338 aa. FbpA
(alternate gene names: mpt44, 85A), precursor of the 85-a
antigen (fibronectin-binding protein A) (mycolyl
transferase 85A) (see citations below), identical to
P17944|P17996|FBPA|MPT44 antigen 85-a precursor from
Mycobacterium bovis (338 aa), FASTA scores: opt: 2341,
E(): 1.2e-132, (100.0% identity in 338 aa overlap); and
highly similar to other Mycobacterial antigen precursors
e.g. O52956|A85A_MYCAV|FBPA antigen 85-a precursor (85A)
from Mycobacterium avium (347 aa), FASTA scores: opt:
1987, E(): 1.7e-111, (82.55% identity in 338 aa overlap);
Q05861|A85A_MYCLE|FBPA|ML0097 antigen 85-a precursor (85A)
from Mycobacterium leprae (330 aa), FASTA scores: opt:
1936, E(): 1.9e-108, (83.0% identity in 329 aa overlap);
O06052|A85A_MYCGO|FBPA antigen 85-a precursor (85A) from
Mycobacterium gordonae (339 aa), FASTA scores: opt:
1932,E(): 3.3e-108, (80.45% identity in 338 aa overlap);
etc. Also highly similar to
P31952|A85B_MYCTU|FBPB|Rv1886c|MT1934|MTCY180.32 secreted
antigen 85-B from Mycobacterium tuberculosis (325
aa),FASTA scores: opt: 1830, E(): 3.9e-102, (78.85%
identity in 317 aa overlap);
P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|FBPC2
secreted antigen 85-C from Mycobacterium tuberculosis (340
aa), FASTA scores: opt: 1597, E(): 3.4e-88, (67.25%
identity in 336 aa overlap). Predicted possible vaccine
candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3804c"
/db_xref="EnsemblGenomes-Tr:CCP46633"
/db_xref="GOA:P9WQP3"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:1SFR"
/db_xref="UniProtKB/Swiss-Prot:P9WQP3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46633.1"
/translation="MQLVDRVRGAVTGMSRRLVVGAVGAALVSGLVGAVGGTATAGAF
SRPGLPVEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDINTPAFE
WYDQSGLSVVMPVGGQSSFYSDWYQPACGKAGCQTYKWETFLTSELPGWLQANRHVKP
TGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSGLLDPSQAMGPTLIGLAMGDAGGYK
ASDMWGPKEDPAWQRNDPLLNVGKLIANNTRVWVYCGNGKPSDLGGNNLPAKFLEGFV
RTSNIKFQDAYNAGGGHNGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATPNTGPA
PQGA"
gene complement(4266953..4268836)
/gene="aftB"
/locus_tag="Rv3805c"
CDS complement(4266953..4268836)
/codon_start=1
/transl_table=11
/gene="aftB"
/locus_tag="Rv3805c"
/product="Possible arabinofuranosyltransferase AftB"
/note="Rv3805c, (MTV026.10c), len: 627 aa. Possible
aftB,arabinofuranosyltransferase (See Seidel et al.,
2007). Probable conserved transmembrane protein,
equivalent, but shorter 19 aa, to Q9CDB4|ML0096 putative
membrane protein from Mycobacterium leprae (649 aa), FASTA
scores: opt: 3511, E(): 1.1e-204, (80.9% identity in 629
aa overlap). Equivalent to AAK48278 from Mycobacterium
tuberculosis strain CDC1551 (641 aa) but shorter 14 aa. A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3805c"
/db_xref="EnsemblGenomes-Tr:CCP46634"
/db_xref="GOA:O53582"
/db_xref="UniProtKB/Swiss-Prot:O53582"
/protein_id="CCP46634.1"
/translation="MVRVSLWLSVTAVAVLFGWGSWQRRWIADDGLIVLRTVRNLLAG
NGPVFNQGERVEANTSTAWTYLLYVGGWVGGPMRLEYVALALAMVLSLLGMVLLMLGT
GRLYAPSLRGRRAIMLPAGALVYIAVPPARDFATSGLESGLVLAYLGLLWWMMVCWSQ
PLRARPDSQMFLGALAFVAGCSVLVRPEFALIGGLALIMMLIAARTWRRRVLIVLAGG
FLPVAYQIFRMGYYGLLVPSTALAKDAAGDKWSQGMIYVSNFNRPYALWVPLVLSVPL
GLLLMTARRRPSFLRPVLAPDYGRVARAVQSPPAVVAFIVGSGVLQALYWIRQGGDFM
HGRVLLAPLFCLLAPVGVIPILLPDGKDFSRETGRWLVGALSGLWLGIAGWSLWAANS
PGMGDDATRVTYSGIVDERRFYAQATGHAHPLTAADYLDYPRMAAVLTALNNTPEGAL
LLPSGNYNQWDLVPMIRPSSGTAPGGKPAPKPQHAVFFTNMGMLGMNVGLDVRVIDQI
GLVNPLAAHTERLKHARIGHDKNLFPDWVIADGPWVKWYPGIPGYIDQQWVTQAEAAL
QCPATRAVLNSVRAPITLHRFLSNVLHSYEFTRYRIDRVPRYELVRCGLDVPDGPGPP
PRE"
gene complement(4268925..4269833)
/gene="ubiA"
/locus_tag="Rv3806c"
CDS complement(4268925..4269833)
/codon_start=1
/transl_table=11
/gene="ubiA"
/locus_tag="Rv3806c"
/product="Decaprenylphosphoryl-5-phosphoribose (DPPR)
synthase (decaprenyl-phosphate
5-phosphoribosyltransferase)"
/note="Rv3806c, (MTV026.11c), len: 302 aa.
UbiA,decaprenylphosphoryl-5-phosphoribose (DPPR) synthase
(See Huang et al., 2005), equivalent to Q9CDB5|ML0095
putative integral membrane protein from Mycobacterium
leprae (302 aa), FASTA scores: opt: 1677, E(): 3.9e-103,
(83.75% identity in 302 aa overlap). Also highly similar
to others e.g. Q9KZA2|SC5G8.12 putative integral membrane
protein from Streptomyces coelicolor (322 aa), FASTA
scores: opt: 937, E(): 2e-54, (51.4% identity in 292 aa
overlap); AAK79783|CAC1818 conserved membrane protein,
possible 4-hydroxybenzoate from Clostridium acetobutylicum
(290 aa),FASTA scores: opt: 467, E(): 1.5e-23, (26.9%
identity in 290 aa overlap); Q98KY3|MLL1266 nodulation
protein NOEC (potential integral membrane protein) from
Rhizobium loti (Mesorhizobium loti) (297 aa), FASTA
scores: opt: 331, E(): 1.4e-14, (27.4% identity in 299 aa
overlap); etc. And highly similar to C-terminal part of
Q981F8|MLR9393 nodulation protein NOEC (potential integral
membrane protein) from Rhizobium loti (Mesorhizobium loti)
plasmid pMLa (541 aa), FASTA scores: opt: 388, E(): 4e-18,
(30.9% identity in 301 aa overlap); and P55585|Y4NM_RHISN
integral membrane protein (possible permease/transporter)
from Rhizobium sp. strain NGR234 plasmid sym pNGR234a (516
aa),FASTA scores: opt: 380, E(): 1.3e-17, (31.85% identity
in 295 aa overlap). Contains PS00225 Crystallins beta and
gamma 'Greek key' motif signature."
/db_xref="EnsemblGenomes-Gn:Rv3806c"
/db_xref="EnsemblGenomes-Tr:CCP46635"
/db_xref="GOA:P9WFR5"
/db_xref="InterPro:IPR000537"
/db_xref="InterPro:IPR039653"
/db_xref="UniProtKB/Swiss-Prot:P9WFR5"
/inference="protein motif:PROSITE:PS00225"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46635.1"
/translation="MSEDVVTQPPANLVAGVVKAIRPRQWVKNVLVLAAPLAALGGGV
RYDYVEVLSKVSMAFVVFSLAASAVYLVNDVRDVEADREHPTKRFRPIAAGVVPEWLA
YTVAVVLGVTSLAGAWMLTPNLALVMVVYLAMQLAYCFGLKHQAVVEICVVSSAYLIR
AIAGGVATKIPLSKWFLLIMAFGSLFMVAGKRYAELHLAERTGAAIRKSLESYTSTYL
RFVWTLSATAVVLCYGLWAFERDGYSGSWFAVSMIPFTIAILRYAVDVDGGLAGEPED
IALRDRVLQLLALAWIATVGAAVAFG"
gene complement(4269840..4270337)
/locus_tag="Rv3807c"
CDS complement(4269840..4270337)
/codon_start=1
/transl_table=11
/locus_tag="Rv3807c"
/product="Possible conserved transmembrane protein"
/note="Rv3807c, (MTV026.12), len: 165 aa. Possible
conserved transmembrane protein, equivalent to
Q9CDB6|ML0094 putative membrane protein from Mycobacterium
leprae (192 aa), FASTA scores: opt: 714, E():
2.4e-38,(72.85% identity in 151 aa overlap). Also highly
similar to Q9KZA3|SC5G8.11 putative integral membrane
protein from Streptomyces coelicolor (169 aa), FASTA
scores: opt: 324,E(): 1.1e-13, (41.5% identity in 159 aa
overlap); and similar in part to others e.g.
Q9K3L3|SCG20A.27 putative integral membrane protein from
Streptomyces coelicolor (230 aa), FASTA scores: opt: 277,
E(): 1.3e-10, (41.65% identity in 168 aa overlap);
P72269|ORF8 hypothetical protein from Rhodococcus
erythropolis (487 aa) FASTA scores: opt: 229,E(): 2.7e-07,
(36.25% identity in 149 aa overlap); O86625|SC3A7.24c
putative integral membrane protein from Streptomyces
coelicolor (201 aa) FASTA scores: opt: 200,E(): 9.1e-06,
(34.95% identity in 146 aa overlap); Q9KYD7|SCD72A.19
putative integral membrane protein from Streptomyces
coelicolor (238 aa) FASTA scores: opt: 178,E(): 0.00026,
(35.7% identity in 112 aa overlap); etc. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3807c"
/db_xref="EnsemblGenomes-Tr:CCP46636"
/db_xref="GOA:P9WI53"
/db_xref="InterPro:IPR000326"
/db_xref="InterPro:IPR036938"
/db_xref="UniProtKB/Swiss-Prot:P9WI53"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46636.1"
/translation="MVAVQSALVDRPGMLATARGLSHFGEHCIGWLILALLGAIALPR
RRREWLVAGAGAFVAHAIAVLIKRLVRRQRPDHPAIAVNVDTPSQLSFPSAHATSTTA
AALLMGRATGLPLPVVLVPPMALSRILLGVHYPSDVAVGVALGATVGAIVDSVGGGRQ
RARKR"
gene complement(4270366..4272279)
/gene="glfT2"
/locus_tag="Rv3808c"
CDS complement(4270366..4272279)
/codon_start=1
/transl_table=11
/gene="glfT2"
/locus_tag="Rv3808c"
/product="Bifunctional UDP-galactofuranosyl transferase
GlfT2"
/note="Rv3808c, (MTV026.13c), len: 637 aa.
GlfT2,bifunctional UDP-galactofuranosyl transferase (see
citations below). Equivalent to Q9CDB7|ML0093 hypothetical
protein from Mycobacterium leprae (643 aa), FASTA scores:
opt: 3751, E(): 0, (85.4% identity in 643 aa overlap).
Contains a beta-glycosyltransferase domain A. Note that
previously known as glfT. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et
al.,2004)."
/db_xref="EnsemblGenomes-Gn:Rv3808c"
/db_xref="EnsemblGenomes-Tr:CCP46637"
/db_xref="GOA:O53585"
/db_xref="InterPro:IPR029044"
/db_xref="InterPro:IPR040492"
/db_xref="PDB:4FIX"
/db_xref="PDB:4FIY"
/db_xref="UniProtKB/Swiss-Prot:O53585"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46637.1"
/translation="MSELAASLLSRVILPRPGEPLDVRKLYLEESTTNARRAHAPTRT
SLQIGAESEVSFATYFNAFPASYWRRWTTCKSVVLRVQVTGAGRVDVYRTKATGARIF
VEGHDFTGTEDQPAAVETEVVLQPFEDGGWVWFDITTDTAVTLHSGGWYATSPAPGTA
NIAVGIPTFNRPADCVNALRELTADPLVDQVIGAVIVPDQGERKVRDHPDFPAAAARL
GSRLSIHDQPNLGGSGGYSRVMYEALKNTDCQQILFMDDDIRLEPDSILRVLAMHRFA
KAPMLVGGQMLNLQEPSHLHIMGEVVDRSIFMWTAAPHAEYDHDFAEYPLNDNNSRSK
LLHRRIDVDYNGWWTCMIPRQVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTLPGA
AIWHMAWSDKDDAIDWQAYFHLRNRLVVAAMHWDGPKAQVIGLVRSHLKATLKHLACL
EYSTVAIQNKAIDDFLAGPEHIFSILESALPQVHRIRKSYPDAVVLPAASELPPPLHK
NKAMKPPVNPLVIGYRLARGIMHNLTAANPQHHRRPEFNVPTQDARWFLLCTVDGATV
TTADGCGVVYRQRDRAKMFALLWQSLRRQRQLLKRFEEMRRIYRDALPTLSSKQKWET
ALLPAANQEPEHG"
gene complement(4272276..4273475)
/gene="glf"
/gene_synonym="ceoA"
/locus_tag="Rv3809c"
CDS complement(4272276..4273475)
/codon_start=1
/transl_table=11
/gene="glf"
/gene_synonym="ceoA"
/locus_tag="Rv3809c"
/product="UDP-galactopyranose mutase Glf (UDP-GALP mutase)
(NAD+-flavin adenine dinucleotide-requiring enzyme)"
/note="Rv3809c, (MTV026.14), len: 399 aa. Glf (alternate
gene name: ceoA), UDP-galactopyranose mutase (see
citations below), identical to previously sequenced gene,
and equivalent to Q9CDB8|GLF|ML0092 putative
UDP-galactopyranose mutase from Mycobacterium leprae (413
aa), FASTA scores: opt: 2347, E(): 1.3e-140, (86.6%
identity in 396 aa overlap). Also highly similar to others
e.g. AAK61905|EPSJ UDP-galactopyranose mutase (protein
involved in exopolysaccharides biosynthesis) from
Streptococcus thermophilus (365 aa), FASTA scores: opt:
972, E(): 5.9e-54, (45.85% identity in 375 aa overlap);
P37747|GLF_ECOLI|B2036 UDP-galactopyranose mutase from
Escherichia coli strain K12 (367 aa), FASTA scores: opt:
958, E(): 4.5e-53, (43.55% identity in 379 aa overlap);
O86897|CAP33FN from Streptococcus pneumoniae (369 aa)
FASTA scores: opt: 954, E(): 8.1e-53, (44.8% identity in
375 aa overlap); etc. Cofactor: FAD (by similarity).
N-terminal SHOWS similarity to FAD or NAD containing
proteins."
/db_xref="EnsemblGenomes-Gn:Rv3809c"
/db_xref="EnsemblGenomes-Tr:CCP46638"
/db_xref="GOA:P9WIQ1"
/db_xref="InterPro:IPR004379"
/db_xref="InterPro:IPR015899"
/db_xref="PDB:1V0J"
/db_xref="PDB:4RPG"
/db_xref="PDB:4RPH"
/db_xref="PDB:4RPJ"
/db_xref="PDB:4RPK"
/db_xref="PDB:4RPL"
/db_xref="UniProtKB/Swiss-Prot:P9WIQ1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46638.1"
/translation="MQPMTARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIG
GNAYSEAEPQTGIEVHKYGAHLFHTSNKRVWDYVRQFTDFTDYRHRVFAMHNGQAYQF
PMGLGLVSQFFGKYFTPEQARQLIAEQAAEIDTADAQNLEEKAISLIGRPLYEAFVKG
YTAKQWQTDPKELPAANITRLPVRYTFDNRYFSDTYEGLPTDGYTAWLQNMAADHRIE
VRLNTDWFDVRGQLRPGSPAAPVVYTGPLDRYFDYAEGRLGWRTLDFEVEVLPIGDFQ
GTAVMNYNDLDVPYTRIHEFRHFHPERDYPTDKTVIMREYSRFAEDDDEPYYPINTEA
DRALLATYRARAKSETASSKVLFGGRLGTYQYLDMHMAIASALNMYDNVLAPHLRDGV
PLLQDGA"
gene 4273739..4274593
/gene="pirG"
/gene_synonym="erp"
/gene_synonym="P36"
/locus_tag="Rv3810"
CDS 4273739..4274593
/codon_start=1
/transl_table=11
/gene="pirG"
/gene_synonym="erp"
/gene_synonym="P36"
/locus_tag="Rv3810"
/product="Exported repetitive protein precursor PirG (cell
surface protein) (EXP53)"
/note="Rv3810, (MTV026.15), len: 284 aa. PirG (alternate
gene names: P36 or erp for Exported Repeated Protein),
cell surface protein precursor (see citations below),
equivalent to P19361|28KD_MYCLE|ML0091 28 KDA antigen
precursor from Mycobacterium leprae (236 aa), FASTA
scores: opt: 555, E(): 9.8e-18, (52.65% identity in 281 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3810"
/db_xref="EnsemblGenomes-Tr:CCP46639"
/db_xref="GOA:P9WIQ7"
/db_xref="InterPro:IPR008164"
/db_xref="UniProtKB/Swiss-Prot:P9WIQ7"
/protein_id="CCP46639.1"
/translation="MPNRRRRKLSTAMSAVAALAVASPCAYFLVYESTETTERPEHHE
FKQAAVLTDLPGELMSALSQGLSQFGINIPPVPSLTGSGDASTGLTGPGLTSPGLTSP
GLTSPGLTDPALTSPGLTPTLPGSLAAPGTTLAPTPGVGANPALTNPALTSPTGATPG
LTSPTGLDPALGGANEIPITTPVGLDPGADGTYPILGDPTLGTIPSSPATTSTGGGGL
VNDVMQVANELGASQAIDLLKGVLMPSIMQAVQNGGAAAPAASPPVPPIPAAAAVPPT
DPITVPVA"
gene 4274798..4276417
/gene_synonym="csp"
/locus_tag="Rv3811"
CDS 4274798..4276417
/codon_start=1
/transl_table=11
/gene_synonym="csp"
/locus_tag="Rv3811"
/product="Conserved hypothetical protein"
/note="Rv3811, (MTV026.16), len: 539 aa. Conserved
hypothetical protein, showing some similarity to
Q9KZK5|SCE34.21c putative secreted protein from
Streptomyces coelicolor (416 aa), FASTA scores: opt:
603,E(): 8.1e-26, (34.4% identity in 404 aa overlap);
Q9S2P9|SC5F7.14c hypothetical 31.9 KDA protein from
Streptomyces coelicolor (308 aa), FASTA scores: opt:
472,E(): 9.5e-19, (37.5% identity in 208 aa overlap).
Middle section (approximately aa 185-350/390) shows some
similarity with Q9GK12 peptidoglycan recognition protein
precursor from Camelus dromedarius (Dromedary) (Arabian
camel) (193 aa) FASTA scores: opt: 274, E():
4.6e-08,(32.2% identity in 177 aa overlap);
O75594|PGLYRP|PGRP from Homo sapiens (Human) (196 aa),
FASTA scores: opt: 272, E(): 6e-08, (30.9% identity in 220
aa overlap); Q9JLN4|PGRP peptidoglycan recognition protein
from Rattus norvegicus (Rat) (182 aa), FASTA scores: opt:
253, E(): 6.2e-07,(32.15% identity in 171 aa overlap);
etc. C-terminal end shows similarity with
Q01377|CSP1_CORGL PS1 protein precursor (one of the two
major secreted proteins) from Corynebacterium glutamicum
(Brevibacterium flavum) (657 aa), FASTA scores: opt: 250,
E(): 2.7e-06, (39.45% identity in 109 aa overlap).
Contains PS00687 Aldehydedehydrogenases glutamic acid
active site. Note that previously known as csp."
/db_xref="EnsemblGenomes-Gn:Rv3811"
/db_xref="EnsemblGenomes-Tr:CCP46640"
/db_xref="GOA:Q79F96"
/db_xref="InterPro:IPR002502"
/db_xref="InterPro:IPR006619"
/db_xref="InterPro:IPR013207"
/db_xref="InterPro:IPR015510"
/db_xref="InterPro:IPR036505"
/db_xref="UniProtKB/TrEMBL:Q79F96"
/inference="protein motif:PROSITE:PS00687"
/protein_id="CCP46640.1"
/translation="MAATVVIVAWIANRPPASSHEPSPTPNTQLAEQPLIGLGGGVTV
RELTQDTPFSLVALTGDLAGTSARVRAKRPDGDWGPWYQTEYETEPRDPAGTDGSVEL
GGLNPGPRSTDPVFVGTTTTVQVAVTRPIDAPITQPPAGRPPNDLLDSGLGYRPATKE
QPFGQNISAILISPPQAPPGTQWTPPTAVTMAGQPPAIISRAEWGADESLRCETPEYD
RGVRAAVVHHTAGSNDYSPLESAGIVKAIYTYHSKTLGWCDIAYNALVDKYGQVFEGS
AGGLTKPVEGFHTGGFNRNTWGVAMIGNFDDVAPTPIQIRTVGRLLGWRLGMDDVDPR
SMVDLQSAGSSYTTFPGGAIARLPAIFTHRDVGNTDCPGNAAYAVMDEIRDIAAHFND
PPEELIKALEGGAIYQRWQALGGMNSALGAPTSPEADAADGARYATFAKGAMYWSPVT
DAQPITGAIYEAWASQSYERGPLGLPTSAEIQEPLQITQNFQHGTLNFERLTGNVTEV
VDGITTPLATRPPSGPTVPPEHFTLPTHPIT"
gene 4276571..4278085
/gene="PE_PGRS62"
/locus_tag="Rv3812"
CDS 4276571..4278085
/codon_start=1
/transl_table=11
/gene="PE_PGRS62"
/locus_tag="Rv3812"
/product="PE-PGRS family protein PE_PGRS62"
/note="Rv3812, (MTV026.17, MTCY409.18c), len: 504 aa.
PE_PGRS62, Member of the Mycobacterium tuberculosis PE
family, PGRS subfamily of gly-rich proteins (see citations
below), similar to many e.g. P96828|Rv0151c|MTCI5.25c (588
aa), FASTA scores: opt: 389, E(): 6.2e-14, (29.2% identity
in 473 aa overlap); MTCY7H7B_27; MTCY493_24; MTCY441_4;
MTCY39_36; MTCY1A11_4; MTCY359_33; MTCY130_10; MTCY98_9;
etc. The transcription of this CDS seems to be activated
in macrophages (see Ramakrishnan et al., 2000)."
/db_xref="EnsemblGenomes-Gn:Rv3812"
/db_xref="EnsemblGenomes-Tr:CCP46641"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N680"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46641.1"
/translation="MSFVVTVPEAVAAAAGDLAAIGSTLREATAAAAGPTTGLAAAAA
DDVSIAVSQLFGRYGQEFQTVSNQLAAFHTEFVRTLNRGAAAYLNTESANGGQLFGQI
EAGQRAVSAAAAAAPGGAYGQLVANTATNLESLYGAWSANPFPFLRQIIANQQVYWQQ
IAAALANAVQNFPALVANLPAAIDAAVQQFLAFNAAYYIQQIISSQIGFAQLFATTVG
QGVTSVIAGWPNLAAELQLAFQQLLVGDYNAAVANLGKAMTNLLVTGFDTSDVTIGTM
GTTISVTAKPKLLGPLGDLFTIMTIPAQEAQYFTNLMPPSILRDMSQNFTNVLTTLSN
PNIQAVASFDIATTAGTLSTFFGVPLVLTYATLGAPFASLNAIATSAETIEQALLAGN
YLGAVGALIDAPAHALDGFLNSATVLDTPILVPTGLPSPLPPTVGITLHLPFDGILVP
PHPVTATISFPGAPVPIPGFPTTVTVFGTPFMGMAPLLINYIPQQLALAIKPAA"
gene complement(4278394..4279215)
/locus_tag="Rv3813c"
CDS complement(4278394..4279215)
/codon_start=1
/transl_table=11
/locus_tag="Rv3813c"
/product="Conserved protein"
/note="Rv3813c, (MTCY409.17), len: 273 aa. Conserved
protein, equivalent to Q9CDB9|ML0089 hypothetical protein
from Mycobacterium leprae (281 aa) FASTA scores: opt:
1479,E(): 9.6e-81, (80.45% identity in 271 aa overlap);
and similar to Q98LI0|MLL1014 from (280 aa). Also similar
to many hypothetical proteins from several organisms e.g.
Q9ZBX2|SCD78.27c from Streptomyces coelicolor (280
aa),FASTA scores: opt: 597, E(): 2.2e-28, (43.25% identity
in 266 aa overlap); Q9RXR7|DR0240 from Deinococcus
radiodurans (284 aa), FASTA scores: opt: 543, E():
3.5e-25, (38.65% identity in 264 aa overlap);
Q99YH5|SPY1700 from Streptococcus pyogenes (274 aa) FASTA
scores: opt: 373,E(): 4.3e-15, (30.75% identity in 270 aa
overlap); P70947|YITU from Bacillus subtilis (270 aa)
FASTA scores: opt: 353, E(): 6.5e-14, (30.0% identity in
280 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3813c"
/db_xref="EnsemblGenomes-Tr:CCP46642"
/db_xref="GOA:O07810"
/db_xref="InterPro:IPR000150"
/db_xref="InterPro:IPR006379"
/db_xref="InterPro:IPR023214"
/db_xref="InterPro:IPR036412"
/db_xref="UniProtKB/TrEMBL:O07810"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46642.1"
/translation="MKPTVPALVACDVDGTLLDDGETVTKRTRDAVHAAVDAGTHFIL
ATGRPPRWVRPIVDALGFAPMAVCANGAVIYDPGTDRVMSVRTLPVDALATLAEVATR
VIPGAGLAVERIGERAHDTATPQFVSSPGYEHAWLNPDNTEVSIDHLLSAPAIKLLIR
KAGAASADMAAELAKHVGFEGDITYSTNNGLVEIVPLGISKATGVDEIARPLGISDAE
VVAFGDMPNDVPMLLRAGLGVAMGNAHPDALAVADEVTAPNSEDGVARVLERWWS"
gene complement(4279230..4280015)
/locus_tag="Rv3814c"
CDS complement(4279230..4280015)
/codon_start=1
/transl_table=11
/locus_tag="Rv3814c"
/product="Possible acyltransferase"
/note="Rv3814c, (MTCY409.16), len: 261 aa. Possible
acyltransferase, highly similar to Q9CDC0|ML0087 putative
acyltransferase from Mycobacterium leprae (257 aa), FASTA
scores: opt: 753, E(): 7.7e-42, (46.75% identity in 246 aa
overlap). Also highly similar to many acyltransferases and
hypothetical proteins e.g. Q9K3R3|2SCG4.01 putative
acyltransferase from Streptomyces coelicolor (242
aa),FASTA scores: opt: 587, E(): 4.6e-31, (41.95% identity
in 243 aa overlap); Q9ZBS1|SC7A1.02 putative
acyltransferase from Streptomyces coelicolor (264 aa),
FASTA scores: opt: 293, E(): 6.6e-12, (29.2% identity in
267 aa overlap); Q9PNZ5|AAS|CJ0938 putative
2-acylglycerophosphoethanolamine acyltransferase /
acyl-acyl carrier protein synthetase from Campylobacter
jejuni (1170 aa), FASTA scores: opt: 274,E(): 3.9e-10,
(29.1% identity in 219 aa overlap) (similarity only with
middle section); Q9EY25 putative acetyl transferase from
Xanthomonas oryzae pv. oryzae (249 aa), FASTA scores: opt:
238, E(): 2.4e-08, (29.2% identity in 209 aa overlap);
etc. Also highly similar to downstream ORFs
O07808|Rv3815c|MTCY409.15 putative acyltransferase from
Mycobacterium tuberculosis (251 aa), FASTA scores: opt:
1069, E(): 2.1e-62, (60.4% identity in 245 aa overlap);
and O07807|Rv3816c|MTCY409.14 putative acyltransferase
from Mycobacterium tuberculosis (259 aa),FASTA scores:
opt: 776, E(): 2.5e-43, (50.9% identity in 228 aa
overlap). And similar to O53516|Rv2182c|MTV021.15c
hypothetical 27.0 KDA protein from Mycobacterium
tuberculosis (247 aa), FASTA scores: opt: 239, E():
2e-08,(30.6% identity in 232 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3814c"
/db_xref="EnsemblGenomes-Tr:CCP46643"
/db_xref="GOA:O07809"
/db_xref="InterPro:IPR002123"
/db_xref="UniProtKB/TrEMBL:O07809"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46643.1"
/translation="MAEPFFRMMEILVPSIVAANGNKITFEGLENIPERGGALIALNH
TSYVDWVPASIAAHHRRRRLRFMIKAEMQDVRAVNYVIKHAQLIPVDRSVGADAYAVA
VQRLRAGELVGLHPEATISRSLELREFKTGAARMALEAQVPIIPMIVWGAHRIWPKDH
PKNLFRNKIPIVAAIGSPVRPEGNAEQLNAVLRQAMNAILYRVQEEYPHPKGEHWVPR
RLGGGAPTVEESRQLRIAELAKRRQKRGYDGVTSSRRSQVGPH"
gene complement(4280033..4280788)
/locus_tag="Rv3815c"
CDS complement(4280033..4280788)
/codon_start=1
/transl_table=11
/locus_tag="Rv3815c"
/product="Possible acyltransferase"
/note="Rv3815c, (MTCY409.15), len: 251 aa. Possible
acyltransferase, highly similar to Q9CDC0|ML0087 putative
acyltransferase from Mycobacterium leprae (257 aa), FASTA
scores: opt: 845, E(): 2.7e-47, (53.25% identity in 246 aa
overlap). Also highly similar to Q9K3R3|2SCG4.01 putative
acyltransferase from Streptomyces coelicolor (242
aa),FASTA scores: opt: 656, E(): 3.7e-35, (47.85% identity
in 234 aa overlap); and similar to many putative
acyltransferases and hypothetical proteins e.g.
P74498|SLL1848 hypothetical 24.3 KDA protein from
Synechocystis sp. strain PCC 6803 (225 aa) FASTA scores:
opt: 275, E(): 1.2e-10, (34.8% identity in 181 aa
overlap); Q9ZBS1|SC7A1.02 putative acyltransferase from
Streptomyces coelicolor (264 aa), FASTA scores: opt: 266,
E(): 5.2e-10,(29.7% identity in 229 aa overlap);
Q9PNZ5|AAS|CJ0938 putative
2-acylglycerophosphoethanolamine acyltransferase/
acyl-acyl carrier protein synthetase from Campylobacter
jejuni (1170 aa), FASTA scores: opt: 264, E():
2.3e-09,(23.55% identity in 221 aa overlap) (similarity
only with middle section); etc. Also highly similar to
upstream ORF O07809|Rv3814c|MTCY409.16 putative
acyltransferase from Mycobacterium tuberculosis (261 aa),
FASTA scores: opt: 1069, E(): 1e-61, (60.4% identity in
245 aa overlap) ; and downstream ORF
O07807|Rv3816c|MTCY409.14 putative acyltransferase from
Mycobacterium tuberculosis (259 aa) FASTA scores: opt:
847, E(): 2e-47, (55.7% identity in 246 aa overlap). And
similar to O53516|Rv2182c|MTV021.15c hypothetical 27.0 KDA
protein from Mycobacterium tuberculosis (247 aa), FASTA
scores: opt: 237, E(): 3.6e-08, (30.9% identity in 233 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3815c"
/db_xref="EnsemblGenomes-Tr:CCP46644"
/db_xref="GOA:O07808"
/db_xref="InterPro:IPR002123"
/db_xref="UniProtKB/TrEMBL:O07808"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46644.1"
/translation="MAEPTYRVLEILAQLLVLATGTRITYVGEENVPDQGGAVVAINH
TSYVDWLPAALAMHRRRRRMRFMIKAEMQRVRLVNFLIRHTRTIPVDRGAGGSAYAVA
VQRLREGELVGVYPEATISRSFELKGFKTGAARMAAEADVPIVPVVVWGAQRIWTKDH
PRQIGRAKVPVTVQVGRPLRAAAGIEQTNAALRESMTALLWQAQERYPHPAGAYWVPR
RLGGGAPTLAEAARMEADEAAARAASRTPHESR"
gene complement(4280792..4281571)
/locus_tag="Rv3816c"
CDS complement(4280792..4281571)
/codon_start=1
/transl_table=11
/locus_tag="Rv3816c"
/product="Possible acyltransferase"
/note="Rv3816c, (MTCY409.14), len: 259 aa. Possible
acyltransferase, equivalent to Q9CDC0|ML0087 putative
acyltransferase from Mycobacterium leprae (257 aa) FASTA
scores: opt: 1401, E(): 1.5e-80, (81.9% identity in 254 aa
overlap). Also highly similar to many putative
acyltransferases and hypothetical proteins e.g.
Q9K3R3|2SCG4.01 putative acyltransferase from Streptomyces
coelicolor (242 aa), FASTA scores: opt: 758, E():
2.4e-40,(51.7% identity in 234 aa overlap);
Q9ZBS1|SC7A1.02 putative acyltransferase from Streptomyces
coelicolor (264 aa), FASTA scores: opt: 312, E(): 2e-12,
(29.55% identity in 237 aa overlap); O67841|AAS|AQ_2058
2-acylglycerophosphoethanolamine acyltransferase from
Aquifex aeolicus (211 aa), FASTA scores: opt: 281, E():
1.5e-10, (32.7% identity in 162 aa overlap); etc. Also
highly similar to upstream ORFs O07808|Rv3815c|MTCY409.15
putative acyltransferase from Mycobacterium tuberculosis
(251 aa), FASTA scores: opt: 847, E(): 6.7e-46, (55.7%
identity in 246 aa overlap); and O07809|Rv3814c|MTCY409.16
putative acyltransferase from Mycobacterium tuberculosis
(261 aa), FASTA scores: opt: 776, E(): 1.9e-41, (50.9%
identity in 228 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3816c"
/db_xref="EnsemblGenomes-Tr:CCP46645"
/db_xref="GOA:O07807"
/db_xref="InterPro:IPR002123"
/db_xref="UniProtKB/TrEMBL:O07807"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46645.1"
/translation="MEPVYGTVIRLARLSWRIQGLKITVTGVDNLPTSGGAVVAINHT
SYLDFTFAGLPAYQQGLGRKVRFMAKQEVFDHKITGPIMRSLRHIPVDRQDGSASYDA
AVRMLKAGELVGVYPEATISRSFEIKEFKTGAARMAIEAGVPIVPHIVWGAQRIWTKD
RPKKLFRPKVPVTIVVGERIEPTLPTAELNGLLHSRMQHLLERAQELYGPHPAGEFWV
PHRLGGGAPSLAEAARLDAQEAAVRAARRAQRAHPAGAPEQ"
gene 4281647..4282402
/locus_tag="Rv3817"
CDS 4281647..4282402
/codon_start=1
/transl_table=11
/locus_tag="Rv3817"
/product="Possible phosphotransferase"
/note="Rv3817, (MTCY409.13c), len: 251 aa. Possible
phosphotransferase, similar to many phosphotransferases
e.g. O53023 kanamycin marker from Escherichia coli (264
aa), FASTA scores: opt: 232, E(): 7.5e-08, (32.4% identity
in 247 aa overlap); BAA78209|NEO neomycine
phosphotransferase from Drosophila melanogaster (Fruit
fly) (264 aa), FASTA scores: opt: 227, E(): 1.6e-07,
(32.0% identity in 247 aa overlap); AAG09774
aminoglycoside 3'-phosphotransferase from Vibrio cholerae
(264 aa), FASTA scores: opt: 227, E(): 1.6e-07, (32.0%
identity in 247 aa overlap); P00552|KKA2_KLEPN|NEO|KAN
aminoglycoside 3'-phosphotransferase from Klebsiella
pneumoniae (264 aa),FASTA scores: opt: 227, E(): 1.6e-07,
(32.0% identity in 247 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3817"
/db_xref="EnsemblGenomes-Tr:CCP46646"
/db_xref="GOA:O07806"
/db_xref="InterPro:IPR002575"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR024165"
/db_xref="UniProtKB/TrEMBL:O07806"
/protein_id="CCP46646.1"
/translation="MSFPSSPPALPAIVARFAVGRPVRAVWVNELGGVTFRVDSGMGA
GCEFIKVARRGTADFANEARRLRWAAPYLAVPRVLGVGVDGDWAWLHTDALPGLSAVH
PRWRASPQVAVPALGAGLRTLHDSLPVHSCPFDWSTASRLAKLAPARRAELGDSPPVD
RLVVCHGDACSPNTILDDTGRCCGHVDFGNLGVADRWADLAVATLSLQWNFPDYPGQV
RDDEFFAAYGVAPDPARIDYYRRLWQAEDDSSR"
gene 4282449..4283999
/locus_tag="Rv3818"
CDS 4282449..4283999
/codon_start=1
/transl_table=11
/locus_tag="Rv3818"
/product="Unknown protein"
/note="Rv3818, (MTCY409.12c), len: 516 aa. Unknown
protein."
/db_xref="EnsemblGenomes-Gn:Rv3818"
/db_xref="EnsemblGenomes-Tr:CCP46647"
/db_xref="GOA:P9WH21"
/db_xref="InterPro:IPR017941"
/db_xref="InterPro:IPR036866"
/db_xref="InterPro:IPR036922"
/db_xref="UniProtKB/Swiss-Prot:P9WH21"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46647.1"
/translation="MQVTSVGHAGFLIQTQAGSILCDPWVNPAYFASWFPFPDNSGLD
WGALGECDYLYVSHLHKDHFDAENLRAHVNKDAVVLLPDFPVPDLRNELQKLGFHRFF
ETTDSVKHRLRGPNGDLDVMIIALRAPADGPIGDSALVVADGETTAFNMNDARPVDLD
VLASEFGHIDVHMLQYSGAIWYPMVYDMPARAKDAFGAQKRQRQMDRARQYIAQVGAT
WVVPSAGPPCFLAPELRHLNDDGSDPANIFPDQMVFLDQMRAHGQDGGLLMIPGSTAD
FTGTTLNSLRHPLPAEQVEAIFTTDKAAYIADYADRMAPVLAAQKAGWAAAAGEPLLQ
PLRTLFEPIMLQSNEICDGIGYPVELAIGPETIVLDFPKRAVREPIPDERFRYGFAIA
PELVRTVLRDNEPDWVNTIFLSTRFRAWRVGGYNEYLYTFFKCLTDERIAYADGWFAE
AHDDSSSITLNGWEIQRRCPHLKADLSKFGVVEGNTLTCNLHGWQWRLDDGRCLTARG
HQLRSSRP"
gene 4283996..4284331
/locus_tag="Rv3819"
CDS 4283996..4284331
/codon_start=1
/transl_table=11
/locus_tag="Rv3819"
/product="Unknown protein"
/note="Rv3819, (MTCY409.11c), len: 111 aa. Unknown
protein. Contains PS00012 Phosphopantetheine attachment
site."
/db_xref="EnsemblGenomes-Gn:Rv3819"
/db_xref="EnsemblGenomes-Tr:CCP46648"
/db_xref="UniProtKB/TrEMBL:O07804"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46648.1"
/translation="MMQFYDDGVVQLDRAALTLRRYHFPSGTAKVIPLDQIRGYQAES
LGFLMARFNIWGRPDLRRWLPLDVYRPLKSTLVTLDVPGMRPKPACTPTRPKEFIALL
DELLALHRT"
gene complement(4284419..4285825)
/gene="papA2"
/locus_tag="Rv3820c"
CDS complement(4284419..4285825)
/codon_start=1
/transl_table=11
/gene="papA2"
/locus_tag="Rv3820c"
/product="Possible conserved polyketide synthase
associated protein PapA2"
/note="Rv3820c, (MTCY409.10), len: 468 aa. Possible
papA2,conserved polyketide synthase (PKS) associated
protein,highly similar to Q49618|PAPA3|ML1230|B1170_C1_180
PKS-associated protein A3 from Mycobacterium leprae (471
aa), FASTA scores: opt: 1660, E(): 2.7e-102, (53.95%
identity in 456 aa overlap). Also similar to
Q9F2R3|SCD65.19c hypothetical 52.8 KDA protein from
Streptomyces coelicolor (473 aa), FASTA scores: opt:
575,E(): 1.8e-30, (27.8% identity in 464 aa overlap); and
weakly similar to part of other proteins. Also high
similarity with other PKS-associated proteins from
Mycobacterium tuberculosis; O50438|PAPA3|Rv1182|MTV005.18
(472 aa), FASTA scores: opt: 1694, E(): 1.5e-104, (53.8%
identity in 461 aa overlap); and
O07799|PAPA1|Rv3824c|MTCY409.06 (511 aa), FASTA scores:
opt: 1664, E(): 1.6e-102, (53.9% identity in 462 aa
overlap); and similar to C-terminal end of
O53902|PAPA4|Rv1528c|MTV045.02 (165 aa), FASTA scores:
opt: 186, E(): 4.1e-05, (37.9% identity in 66 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3820c"
/db_xref="EnsemblGenomes-Tr:CCP46649"
/db_xref="GOA:P9WIK7"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WIK7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46649.1"
/translation="MFSITTLRDWTPDPGSIICWHASPTAKAKARQAPISEVPPSYQQ
AQHLRRYRDHVARGLDMSRLMIFTWDLPGRCNIRAMNYAINAHLRRHDTYHSWFEFDN
AEHIVRHTIADPADIEVVQAEHQNMTSAELRHHIATPQPLQWDCFLFGIIQSDDHFTF
YASIAHLCVDPMIVGVLFIEIHMMYSALVGGDPPIELPPAGRYDDHCVRQYADTAALT
LDSARVRRWVEFAANNDGTLPHFPLPLGDLSVPHTGKLLTETLMDEQQGERFEAACVA
AGARFSGGVFACAALAERELTNCETFDVVTTTDTRRTPTELRTTGWFTGLVPITVPVA
SGLFDSAARVAQISFDSGKDLATVPFDRVLELARPETGLRPPRPGNFVMSFLDASIAP
LSTVANSDLNFRIYDEGRVSHQVSMWVNRYQHQTTVTVLFPDNPIASESVANYIAAMK
SIYIRTADGTLATLKPGT"
gene 4285973..4286686
/locus_tag="Rv3821"
CDS 4285973..4286686
/codon_start=1
/transl_table=11
/locus_tag="Rv3821"
/product="Probable conserved integral membrane protein"
/note="Rv3821, (MTCY409.09c), len: 237 aa. Probable
conserved integral membrane protein, equivalent to
Q49630|ML1233|B1170_F2_64 hypothetical 24.4 KDA
protein/INTEGRAL MEMBRANE PROTEIN (POTENTIAL) from
Mycobacterium leprae (230 aa), FASTA scores: opt: 619,
E(): 2.4e-32, (46.65% identity in 240 aa overlap). Shows
some similarity to P29466|I1BC_HUMAN|CASP1|IL1BC|IL1BCE
(404 aa), FASTA scores: opt: 126, E(): 0.88, (29.05%
identity in 155 aa overlap). Also highly similar to
P71796|Rv1517|MTCY277.39 HYPOTHETICAL 26.9 KDA PROTEIN
from Mycobacterium tuberculosis (254 aa), FASTA scores:
opt: 284, E(): 5.4e-11, (36.35% identity in 256 aa
overlap). Start site chosen on basis of similarity to
LEPB1170_F2_64 and MTCY277.39, but may extend further
upstream. A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3821"
/db_xref="EnsemblGenomes-Tr:CCP46650"
/db_xref="GOA:O07802"
/db_xref="InterPro:IPR021315"
/db_xref="UniProtKB/Swiss-Prot:O07802"
/protein_id="CCP46650.1"
/translation="MWSTVLVLALSVICEPVRIGLVVLMLNRRRPLLHLLTFLCGGYT
MAGGVAMVTLVVLGATPLAGHFSVAEVQIGTGLIALLIAFALTTNVIGKHVRRATHAR
VGDDGGRVLRESVPPSGAHKLAVRARCFLQGDSLYVAGVSGLGAALPSANYMGAMAAI
LASGATPATQALAVVTFNVVAFTVAEVPLVSYLAAPRKTRAFMAALQSWLRSRSRRDA
ALLVAAGGCLMLTLGLSNL"
gene 4286721..4287935
/locus_tag="Rv3822"
CDS 4286721..4287935
/codon_start=1
/transl_table=11
/locus_tag="Rv3822"
/product="Conserved hypothetical protein"
/note="Rv3822, (MTCY409.08c), len: 404 aa. Conserved
hypothetical protein, similar in part to hypothetical
proteins from Mycobacterium leprae: Q9CC62|ML1232 (358 aa)
FASTA scores: opt: 601, E(): 1.1e-25, (36.7% identity in
335 aa overlap); and Q49633|B1170_F3_112 (391 aa) FASTA
scores: opt: 601, E(): 1.2e-25, (36.25% identity in 347 aa
overlap). Also similar to P71862|Rv3539|MTCY03C7.17c PPE
family protein from Mycobacterium tuberculosis (479
aa),FASTA scores: opt: 547, E(): 1.3e-22, (38.1% identity
in 281 aa overlap); O50440|Rv1184c|MTV005.20c (359 aa);
O06828|Rv1430|MTCY493.24c (528 aa);
O53642|Rv0159c|MTV032.02c (468 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv3822"
/db_xref="EnsemblGenomes-Tr:CCP46651"
/db_xref="GOA:O07801"
/db_xref="InterPro:IPR013228"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:O07801"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46651.1"
/translation="MKCPGVSDCVATVRHDNVFAIAAGLRWSAAVPPLHKGDAVTKLL
VGAIAGGMLACAAILGDGIASADTALIVPGTAPSPYGPLRSLYHFNPAMQPQIGANYY
NPTATRHVVSYPGSFWPVTGLNSPTVGSSVSAGTNNLDAAIRSTDGPIFVAGLSQGTL
VLDREQARLANDPTAPPPGQLTFIKAGDPNNLLWRAFRPGTHVPIIDYTVPAPAESQY
DTINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSATAFSDPARVAPRDITTTTN
SLGATTTTYFIRTDQLPLVRALVDMAGLPPQAAGTVDAALRPIIDRAYQPGPAPAVNP
RDLVQGIRGIPAIAPAIAIPIGSTTGASAATSTAAATAAATNALRGANVGPGANKALS
MVRGLLPKGKKH"
gene complement(4288260..4291529)
/gene="mmpL8"
/locus_tag="Rv3823c"
CDS complement(4288260..4291529)
/codon_start=1
/transl_table=11
/gene="mmpL8"
/locus_tag="Rv3823c"
/product="Conserved integral membrane transport protein
MmpL8"
/note="Rv3823c, (MTCY409.07), len: 1089 aa.
mmpL8,conserved integral membrane transport protein (see
Tekaia et al., 1999), member of RND superfamily,
equivalent to Q49619|MMLA_MYCLE|MMPL10|TP1|ML1231|B1170_C1
_181 putative membrane protein from Mycobacterium leprae
(1008 aa), FASTA scores: opt: 2718, E(): 7.3e-149, (56.25%
identity in 1028 aa overlap). Also similar to others e.g.
Q9XCF6|TMTPC from Mycobacterium avium (974 aa), FASTA
scores: opt: 660, E(): 2.7e-30, (28.2% identity in 1050 aa
overlap); Q9XCF5|TMTPB from Mycobacterium avium (963 aa),
FASTA scores: opt: 653,E(): 6.7e-30, (27.0% identity in
1014 aa overlap); Q9KH53|TMTPC from Mycobacterium
smegmatis (994 aa), FASTA scores: opt: 648, E(): 1.3e-29,
(28.45% identity in 1013 aa overlap); etc. Also highly
similar to other mmpL proteins from Mycobacterium
tuberculosis; O50439|MMLA_MYCTU|MMPL10|RV1183|MT1220|MTV00
5.19 (1002 aa),FASTA scores: opt: 2777, E(): 2.9e-152,
(58.25% identity in 996 aa overlap);
Q50585|MMLC_MYCTU|MMPL12|Rv1522c|MT1573|MTCY19G5.06 (1146
aa), FASTA scores: opt: 2433, E(): 2.1e-132, (49.9%
identity in 1050 aa overlap); and similar to others e.g.
P95235|MML9_MYCTU|MMPL9|Rv2339|MT2402|MTCY98.08 (962
aa),FASTA scores: opt: 651, E(): 8.8e-30, (28.6% identity
in 1038 aa overlap); etc. Belongs to the MmpL family."
/db_xref="EnsemblGenomes-Gn:Rv3823c"
/db_xref="EnsemblGenomes-Tr:CCP46652"
/db_xref="GOA:P9WJU5"
/db_xref="InterPro:IPR000731"
/db_xref="InterPro:IPR004869"
/db_xref="UniProtKB/Swiss-Prot:P9WJU5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46652.1"
/translation="MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPW
VVIAFWVALAGLLAPTVPSLDAISQRHPVAILPSDAPVLVSTRQMTAAFREAGLQSVA
VVVLSDAKGLGAADERSYKELVDALRRDTRDVVMLQDFVTTPPLRELMTSKDNQAWIL
PVGLPGDLGSTQSKQAYARVADIVEHQVAGSTLTANLTGPAATVADLNLTGQRDRSRI
EFAITILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVAIAGLAGLGIANQSIIFM
SGMMVGAGTDYAVFLISRYHDYLRQGADSDQAVKKALTSIGKVIAASAATVAITFLGM
VFTQLGILKTVGPMLGISVAVVFFAAVTLLPALMVLTGRRGWIAPRRDLTRRFWRSSG
VHIVRRPKTHLLASALVLVILAGCAGLARYNYDDRKTLPASVESSIGYAALDKHFPSN
LIIPEYLFIQSSTDLRTPKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSW
QAGEVGSKLDEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDAL
AYLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVLGALDSSP
MCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAVQTLAATVSGLRGALA
TVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGSRQLAEGVQLLVDQVKKMGFGLGE
ASAFLLAMKDTATTPAMAGFYIPPELLSYATGESVKAETMPSEYRDLLGGLNVDQLKK
VAAAFISPDGHSIRYLIQTDLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGL
PVVLKDTRDYSDHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIG
VIVFQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIRTVAST
GGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVRTVTVPAIAVLVGQ
ANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEEEEQSPPDDDDLIGLWLHDGLR
L"
gene complement(4291639..4293174)
/gene="papA1"
/locus_tag="Rv3824c"
CDS complement(4291639..4293174)
/codon_start=1
/transl_table=11
/gene="papA1"
/locus_tag="Rv3824c"
/product="Conserved polyketide synthase associated protein
PapA1"
/note="Rv3824c, (MTCY409.06), len: 511 aa. papA1,
conserved polyketide synthase (PKS) associated protein,
highly similar to Q49618|PAPA3|ML1230|B1170_C1_180
PKS-associated protein A3 from Mycobacterium leprae (471
aa), FASTA scores: opt: 1879, E(): 7.1e-111, (55.5%
identity in 465 aa overlap). Also similar to
Q9F2R3|SCD65.19c hypothetical 52.8 KDA protein from
Streptomyces coelicolor (473 aa),FASTA scores: opt: 476,
E(): 1.7e-22, (26.7% identity in 464 aa overlap); and
similar in part to Q09164|SIMA|CYSYN cyclosporin
synthetase from Tolypocladium inflatum (15281 aa) FASTA
scores: opt: 238, E(): 2.8e-06, (22.35% identity in 371 aa
overlap). Also highly similar to other PKS-associated
proteins from Mycobacterium tuberculosis;
O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt:
1862, E(): 8.4e-110, (55.95% identity in 470 aa overlap);
and upstream ORF O07803|PAPA2|Rv3820c|MTCY409.10 (468 aa)
FASTA scores: opt: 1664, E(): 2.5e-97, (53.9% identity in
462 aa overlap). Contains PS00453 FKBP-type
peptidyl-prolyl cis-trans isomerase signature 1."
/db_xref="EnsemblGenomes-Gn:Rv3824c"
/db_xref="EnsemblGenomes-Tr:CCP46653"
/db_xref="GOA:P9WIK9"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WIK9"
/inference="protein motif:PROSITE:PS00453"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46653.1"
/translation="MRIGPVELSAVKDWDPAPGVLVSWHPTPASCAKALAAPVSAVPP
SYVQARQIRSFSEQAARGLDHSRLLIASVEVFGHCDLRAMTYVINAHLRRHDTYRSWF
ELRDTDHIVRHSIADPADIEFVPTTHGEMTSADLRQHIVATPDSLHWDCFSFGVIQRA
DSFTFYASIDHLHADGQFVGVGLMEFQSMYTALIMGEPPIGLSEAGSYVDFCVRQHEY
TSALTVDSPEVRAWIDFAEINNGTFPEFPLPLGDPSVRCGGDLLSMMLMDEQQTQRFE
SACMAANARFIGGMLACIAIAIHELTGADTYFGITPKDIRTPADLMTQGWFTGQIPVT
VPVAGLSFNEIARIAQTSFDTGADLAKVPFERVVELSPSLRRPQPLFSLVNFFDAQVG
PLSAVTKLFEGLNVGTYSDGRVTYPLSTMVGRFDETAASVLFPDNPVARESVTAYLRA
IRSVCMRIANGGTAERVGNVVALSPGRRNNIERMTWRSCRAGDFIDICNLKVANVTVD
REA"
gene complement(4293225..4299605)
/gene="pks2"
/locus_tag="Rv3825c"
CDS complement(4293225..4299605)
/codon_start=1
/transl_table=11
/gene="pks2"
/locus_tag="Rv3825c"
/product="Polyketide synthase Pks2"
/note="Rv3825c, (MTCY409.05), len: 2126 aa.
pks2,polyketide synthase (see citation below), equivalent
to Q9CD78|mas|ML0139 putative mycocerosic synthase from
Mycobacterium leprae (2116 aa), FASTA scores: opt:
6828,E(): 0, (63.3% identity in 2128 aa overlap); and
Q49624|PKS3|MASA|ML1229|B1170_C2_209 probable mycocerosic
acid synthase from Mycobacterium leprae (2118 aa) FASTA
scores: opt: 5220, E(): 0, (62.4% identity in 2130 aa
overlap); or similar in part to others from Mycobacterium
leprae e.g. Q9CB70|ML2354 polyketide synthase (1822 aa)
FASTA scores: opt: 2787, E(): 2.1e-145, (34.7% identity in
2135 aa overlap). Also highly similar to
Q02251|MCAS_MYCBO|mas mycocerosic acid synthase from
Mycobacterium bovis (2110 aa), FASTA scores: opt:
3495,E(): 2.6e-184, (61.65% identity in 2130 aa overlap).
Also highly similar to other polyketide synthases from
Mycobacterium tuberculosis e.g.
O53901|PKS5|Rv1527c|MTV045.01c|MTCY19G5.01 (2108 aa) FASTA
scores: opt: 9576, E(): 0, (69.8% identity in 2124 aa
overlap); P96291|mas|Rv2940c|MTCY24G1.09|MTCY19H9.08c
(2111 aa), FASTA scores: opt: 3518, E(): 1.4e-185, (64.05%
identity in 2126 aa overlap); O50437|PKS4|Rv1181|MTV005.17
(1582 aa), FASTA scores: opt: 3461, E(): 1.6e-182, (64.55%
identity in 1609 aa overlap); etc. Contains PS00606
Beta-ketoacyl synthases active site and PS00012
Phosphopantetheine attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3825c"
/db_xref="EnsemblGenomes-Tr:CCP46654"
/db_xref="GOA:P9WQE9"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:P9WQE9"
/inference="protein motif:PROSITE:PS00012"
/inference="protein motif:PROSITE:PS00606"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46654.1"
/translation="MGLGSAASGTGADRGAWTLAEPRVTPVAVIGMACRLPGGIDSPE
LLWKALLRGDDLITEVPPDRWDCDEFYDPQPGVPGRTVCKWGGFLDNPADFDCEFFGI
GEREAIAIDPQQRLLLETSWEAMEHAGLTQQTLAGSATGVFAGVTHGDYTMVAADAKQ
LEEPYGYLGNSFSMASGRVAYAMRLHGPAITVDTACSSGLTAVHMACRSLHEGESDVA
LAGGVALMLEPRKAAAGSALGMLSPTGRCRAFDVAADGFVSGEGCAVVVLKRLPDALA
DGDRILAVIRGTSANQDGHTVNIATPSQPAQVAAYRAALAAGGVDAATVGMVEAHGPG
TPIGDPIEYASVSEVYGVDGPCALASVKTNFGHTQSTAGVLGLIKVVLALKHGVVPRN
LHFTRLPDEIAGITTNLFVPEVTTPWPTNGRQVPRRAAVSSYGFSGTNVHAVVEQAPQ
TEAQPHAASTPPTGTPALFTLSASSADALRQTAQRLTDWIQQHADSLVLSDLAYTLAR
RRTHRSVRTAVIASSVDELIAGLGEVADGDTVYQPAVGQDDRGPVWLFSGQGSQWAAM
GADLLTNESVFAATVAELEPLIAAESGFSVTEAMTAPETVTGIDRVQPTIFAMQVALA
ATMAAYGVRPGAVIGHSMGESAAAVVAGVLSAEDGVRVICRRSKLMATIAGSAAMASV
ELPALAVQSELTALGIDDVVVAVVTAPQSTVIAGGTESVRKLVDIWERRDVLARAVAV
DVASHSPQVDPILDELIAALADLNPKAPEIPYYSATLFDPREAPACDARYWADNLRHT
VRFSAAVRSALDDGYRVFAELSPHPLLTHAVDQIAGSVGMPVAALAGMRREQPLPLGL
RRLLTDLHNAGAAVDFSVLCPQGRLVDAPLPAWSHRFLFYDREGVDNRSPGGSTVAVH
PLLGAHVRLPEEPERHAWQADVGTATLPWLGDHRIHNVAALPGAAYCEMALSAARAVL
GEQSEVRDMRFEAMLLLDDQTPVSTVATVTSPGVVDFAVEALQEGVGHHLRRASAVLQ
QVSGECEPPAYDMASLLEAHPCRVDGEDLRRQFDKHGVQYGPAFTGLAVAYVAEDATA
TMLAEVALPGSIRSQQGLYAIHPALLDACFQSVGAHPDSQSVGSGLLVPLGVRRVRAY
APVRTARYCYTRVTKVELVGVEADIDVLDAHGTVLLAVCGLRIGTGVSERDKHNRVLN
ERLLTIEWHQRELPEMDPSGAGKWLLISDCAASDVTATRLADAFREHSAACTTMRWPL
HDDQLAAADQLRDQVGSDEFSGVVVLTGSNTGTPHQGSADRGAEYVRRLVGIARELSD
LPGAVPRMYVVTRGAQRVLADDCVNLEQGGLRGLLRTIGAEHPHLRATQIDVDEQTGV
EQLARQLLATSEEDETAWRDNEWYVARLCPTPLRPQERRTIVADHQQSGMRLQIRTPG
DMQTIELAAFHRVPPGPGQIEVAVRASSVNFADVLIAFGRYPSFEGHLPQLGTDFAGV
VTAVGPGVTDHKVGDHVGGMSPNGCWGTFVTCDARLAATLPPGLGDAQAAAVTTAHAT
AWYGLHELARIRAGDTVLIHSGTGGVGQAAIAIARAAGAEIFATAGTPQRRELLRNMG
IEHVYDSRSIEFAEQIRRDTNGRGVDVVLNSVTGAAQLAGLKLLAFRGRFVEIGKRDI
YGDTKLGLFPFRRNLSFYAVDLGLLSATHPEELRDLLGTVYRLTAAGELPMPQSTHYP
LVEAATAIRVMGNAEHTGKLVLHIPQTGKSLVTLPPEQAQVFRPDGSYIITGGLGGLG
LFLAEKMAAAGCGRIVLNSRTQPTQKMRETIEAIAAMGSEVVVECGDIAQPGTAERLV
ATAVATGLPVRGVLHAAAVVEDATLANITDELLARDWAPKVHGAWELHEATSGQPLDW
FCLFSSAAALTGSPGQSAYSAANSWLDAFAHWRQAQGLPATAIAWGAWSDIGQLGWWS
ASPARASALEESNYTAITPDEGAYAFEALLRHNRVYTGYAPVIGAPWLVAFAERSRFF
EVFSSSNGSGTSKFRVELNELPRDEWPARLRQLVAEQVSLILRRTVDPDRPLPEYGLD
SLGALELRTRIETETGIRLAPKNVSATVRGLADHLYEQLAPDDAPAAALSSQ"
gene 4299812..4301566
/gene="fadD23"
/locus_tag="Rv3826"
CDS 4299812..4301566
/codon_start=1
/transl_table=11
/gene="fadD23"
/locus_tag="Rv3826"
/product="Probable fatty-acid-AMP ligase FadD23
(fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)"
/note="Rv3826, (MTCY409.04c), len: 584 aa. Probable
fadD23,fatty-acid-AMP synthetase, highly similar to P71495
acyl-CoA synthase from Mycobacterium bovis (582 aa), FASTA
scores: opt: 2571, E(): 4.4e-146, (66.15% identity in 576
aa overlap); Q9CD79|FADD28|ML0138 acyl-CoA synthetase from
Mycobacterium leprae (579 aa) FASTA scores: opt: 2520,
E(): 4.9e-143, (65.2% identity in 575 aa overlap);
P54200|FD21_MYCLE putative fatty-acid--CoA ligase
(acyl-CoA synthetase) from Mycobacterium leprae (579 aa),
FASTA scores: opt: 2330, E(): 1.1e-131, (60.2% identity in
578 aa overlap); etc. Also highly similar to others from
Mycobacterium tuberculosis e.g.
P96290|FADD28|Rv2941|MTCY24G1.08c (580 aa), FASTA scores:
opt: 2587, E(): 4.9e-147, (66.5% identity in 576 aa
overlap); O53903|FADD24|Rv1529|MTV045.03 (584 aa), FASTA
scores: opt: 2457, E(): 2.9e-139, (63.35% identity in 584
aa overlap); Q50586|FADD25|Rv1521|MT1572|MTCY19G5.07 (583
aa) FASTA scores: opt: 2389, E(): 3.3e-135, (61.45%
identity in 581 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3826"
/db_xref="EnsemblGenomes-Tr:CCP46655"
/db_xref="GOA:P9WQ47"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR040097"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:P9WQ47"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46655.1"
/translation="MVSLSIPSMLRQCVNLHPDGTAFTYIDYERDSEGISESLTWSQV
YRRTLNVAAEVRRHAAIGDRAVILAPQGLDYIVAFLGALQAGLIAVPLSAPLGGASDE
RVDAVVRDAKPNVVLTTSAIMGDVVPRVTPPPGIASPPTVAVDQLDLDSPIRSNIVDD
SLQTTAYLQYTSGSTRTPAGVMITYKNILANFQQMISAYFADTGAVPPLDLFIMSWLP
FYHDMGLVLGVCAPIIVGCGAVLTSPVAFLQRPARWLQLMAREGQAFSAAPNFAFELT
AAKAIDDDLAGLDLGRIKTILCGSERVHPATLKRFVDRFSRFNLREFAIRPAYGLAEA
TVYVATSQAGQPPEIRYFEPHELSAGQAKPCATGAGTALVSYPLPQSPIVRIVDPNTN
TECPPGTIGEIWVHGDNVAGGYWEKPDETERTFGGALVAPSAGTPVGPWLRTGDSGFV
SEDKFFIIGRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAIAVPSNGVEKLVAIVEL
NNRGNLDTERLSFVTREVTSAISTSHGLSVSDLVLVAPGSIPITTSGKVRRAECVKLY
RHNEFTRLDAKPLQASDL"
mobile_element complement(4301543..4303415)
/mobile_element_type="insertion sequence:IS1537"
/note="IS1537, len: 1873 nt. Insertion sequence IS1537."
gene complement(4301563..4302789)
/locus_tag="Rv3827c"
CDS complement(4301563..4302789)
/codon_start=1
/transl_table=11
/locus_tag="Rv3827c"
/product="Possible transposase"
/note="Rv3827c, (MTCY409.03), len: 408 aa. Possible
transposase within IS1537 element, similar to several
transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|
DR1651|DR1933 transposase from Deinococcus radiodurans(408
aa) FASTA scores: opt: 302, E(): 3.9e-12, (30.75% identity
in 358 aa overlap); Q9RXX7|DR0178 putative transposase
from Deinococcus radiodurans (409 aa), FASTA scores: opt:
297,E(): 8.2e-12, (31.1% identity in 360 aa overlap);
P73816|SLR2062 transposase from Synechocystis sp. strain
PCC 6803 (400 aa), FASTA scores: opt: 296, E():
9.3e-12,(30.05% identity in 353 aa overlap); etc. Highly
similar to proteins from Mycobacterium tuberculosis e.g.
O33333|Rv2791c|MTV002.56c transposase (459 aa) FASTA
scores: opt: 2211, E(): 9.4e-136, (87.75% identity in 367
aa overlap); P95117|Rv2978c|MTCY349.09 hypothetical 51.4
KDA protein (459 aa), FASTA scores: opt: 2165, E():
9e-133,(85.85% identity in 367 aa overlap);
Q10809|YS85_MYCTU|Rv2885c|MT2953|MTCY274.16c hypothetical
51.3 KDA protein (460 aa), FASTA scores: opt: 2127, E():
2.6e-130, (83.95% identity in 368 aa overlap);
O0777|Rv0606|MTCY19H5.16c probable transposase (fragment)
(247 aa), FASTA scores: opt: 1405, E(): 9.3e-84, (85.3%
identity in 238 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3827c"
/db_xref="EnsemblGenomes-Tr:CCP46656"
/db_xref="GOA:O07796"
/db_xref="InterPro:IPR001959"
/db_xref="InterPro:IPR021027"
/db_xref="UniProtKB/TrEMBL:O07796"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46656.1"
/translation="MMARFEVPEGWCVQAFRFTLDPTEDQARALARHFGARRKAYNWA
VATLKADIEAWRVTGIGTVKPSLRVLRKRWNTVKDEVCVNAETGAVWWPECSKEAYAD
GIGGAVDAYWNWQNSRSGKREGKTMGFPRFKKKGRDQDRVTFTTGAMRVEPDRRHLTL
PVVGTVRTHENTRRIERLIATGRARVLAISVRRNGTRLDASVRVLVQRPQQPNVAQPG
SRVGVDVGVRRLATVANEAGAVLEEVPNPRPLDTALKELRYASRARSRCTKGSRRYRE
RTTEISRLHRRVNDVRTHHLHVLTTRLAQTHGHIVVEGLDAAGMLRQKGLPGARARRR
GLSDSALGTPRRHLSYKTGWYGSALVVADRWFPSLSVEPTVRPGLARLVAVKRGREAA
AWLPNNPETGCKSRDH"
gene complement(4302786..4303397)
/locus_tag="Rv3828c"
CDS complement(4302786..4303397)
/codon_start=1
/transl_table=11
/locus_tag="Rv3828c"
/product="Possible resolvase"
/note="Rv3828c, (MTCY409.02), len: 203 aa. Possible
resolvase within IS1537 element, similar to others e.g.
Q97X40|SSO1915 first ORF in transposon ISC1913 from
Sulfolobus solfataricus (213 aa), FASTA scores: opt:
275,E(): 1.6e-11, (30.6% identity in 196 aa overlap);
Q9V1M0|PAB2076 resolvase related protein from Pyrococcus
abyssi (212 aa), FASTA scores: opt: 254, E():
4.2e-10,(29.95% identity in 197 aa overlap); Q9RMU7|ORFA
putative transposase (belongs to the MerR family of
transcriptional regulators) from Helicobacter pylori
(Campylobacter pylori) (217 aa), FASTA scores: opt: 243,
E(): 2.3e-09, (31.8% identity in 154 aa overlap); etc.
Also highly similar to proteins from Mycobacterium
tuberculosis e.g. O33334|Rv2792c|MTV002.57c resolvase (193
aa), FASTA scores: opt: 970, E(): 1.5e-58, (79.25%
identity in 193 aa overlap); O07773|Rv0605|MTCY19H5.17c
putative resolvase (202 aa), FASTA scores: opt: 964, E():
4e-58, (76.25% identity in 202 aa overlap);
P95116|Rv2979c|MTCY349.08 hypothetical 21.4 KDA protein
(194 aa), FASTA scores: opt: 895, E(): 1.8e-53, (74.75%
identity in 194 aa overlap);
Q10831|YS86_MYCTU|Rv2886c|MT2954|MTCY274.17c hypothetical
31.9 KDA protein (295 aa), FASTA scores: opt: 826, E():
1.1e-48, (66.2% identity in 204 aa overlap) (similarity
only at C-terminus); etc. Contains PS00397 Site-specific
recombinases active site. Possible helix-turn-helix motif
from aa 11-32, Score 1305 (+3.63 SD)."
/db_xref="EnsemblGenomes-Gn:Rv3828c"
/db_xref="EnsemblGenomes-Tr:CCP46657"
/db_xref="GOA:O07795"
/db_xref="InterPro:IPR006118"
/db_xref="InterPro:IPR006119"
/db_xref="InterPro:IPR036162"
/db_xref="UniProtKB/TrEMBL:O07795"
/inference="protein motif:PROSITE:PS00397"
/protein_id="CCP46657.1"
/translation="MSVVCCRNRWMNLAVWAERNGVAWVIAYRWFRAGLLPVPAQRVG
RLILVNDPAVEESGRGRTLVYARVSSADQRSDLDRRVARVTAWATSQHLSVDKVVAEG
GWALNGHRRKFFALLGDPVVTRIVVEHRDRFCWFGSEYVEAALVAQGRELVVVDLAEV
DDDLVGDMTEILTSMCARLYGERAAQNGAKRALAAAVGDAEAA"
gene complement(4303398..4305008)
/locus_tag="Rv3829c"
CDS complement(4303398..4305008)
/codon_start=1
/transl_table=11
/locus_tag="Rv3829c"
/product="Probable dehydrogenase"
/note="Rv3829c, (MTCY409.01, MTCY01A6.40), len: 536 aa.
Probable oxidoreductase dehydrogenase, similar to others
e.g. Q9A3T1|CC3121 phytoene dehydrogenase-related protein
from Caulobacter crescentus (543 aa), FASTA scores: opt:
607, E(): 9.2e-28, (28.25% identity in 552 aa overlap);
Q98FP6|MLR3676 phytoene dehydrogenase from Rhizobium loti
(Mesorhizobium loti) (521 aa), FASTA scores: opt: 605,
E(): 1.2e-27, (28.2% identity in 546 aa overlap);
Q97W24|SSO2422 phytoene dehydrogenase related protein from
Sulfolobus solfataricus (518 aa), FASTA scores: opt: 388,
E(): 4.4e-15, (27.35% identity in 530 aa overlap);
Q98BS8|MLL5443 probable dehydrogenase from Rhizobium loti
(Mesorhizobium loti) (524 aa), FASTA scores: opt: 374,
E(): 2.9e-14, (24.35% identity in aa overlap); etc. Also
similar to MTCY493.22c|Rv1432|MTCY493.22c hypothetical
50.5 KDA protein (probable dehydrogenase) from
Mycobacterium tuberculosis (25.1% identity in 295 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3829c"
/db_xref="EnsemblGenomes-Tr:CCP46658"
/db_xref="GOA:O07794"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:O07794"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46658.1"
/translation="MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMAST
VELFDGYRFEIAGSVQFPTSSAVSSELGLDSLPTVDLEVMSVALRGVGDDPVVQFTDP
TKMLTHLHRVHGADAVTGMAGLLAWSQAPTRALGRFEAGTLPKSFDEMYACATNEFER
SAIDDMLFGSVTDVLDRHFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGLG
VPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVR
TAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHFALAQP
PAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADPTVVLQIPSLHDPSL
APAGKQAASAFAMWFPIEGGSKYGGYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTF
TPKHMGVMFGAPGGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAGLYLGSAGCHGGPG
ITFIPGYNAARQALADRRAANCCVLSGR"
gene complement(4305056..4305685)
/locus_tag="Rv3830c"
CDS complement(4305056..4305685)
/codon_start=1
/transl_table=11
/locus_tag="Rv3830c"
/product="Transcriptional regulatory protein (probably
TetR-family)"
/note="Rv3830c, (MTCY01A6.39), len: 209 aa. Probable
transcriptional regulator TetR family, similar to others
e.g. P39885|TCMR_STRGA tetracenomycin C transcriptional
repressor from Streptomyces glaucescens (226 aa) FASTA
scores: opt: 255, E(): 6.1e-10, (33.65% identity in 202 aa
overlap); Q9RDR0|SC4A7.02 putative transcriptional
regulator from Streptomyces coelicolor (227 aa) FASTA
scores: opt: 230, E(): 2.8e-08, (30.05% identity in 213 aa
overlap); Q9EWU3|3SC5B7.06 putative regulatory protein
from Streptomyces coelicolor (244 aa), FASTA scores: opt:
221,E(): 1.2e-07, (32.05% identity in 181 aa overlap);
Q9AJ68|BUTR putative transcriptional repressor from
Streptomyces cinnamonensis (268 aa), FASTA scores: opt:
216, E(): 2.7e-07, (37.8% identity in 119 aa overlap);
etc. Contains possible helix-turn-helix motif from aa
33-54,Score 1699 (+4.97 SD). Seems to belong to the
TetR/AcrR family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3830c"
/db_xref="EnsemblGenomes-Tr:CCP46659"
/db_xref="GOA:P96248"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR023772"
/db_xref="UniProtKB/TrEMBL:P96248"
/protein_id="CCP46659.1"
/translation="MVRPPQTARSERTREALRQAALVRFLAQGVEATSAEQIAEDAGV
SLRTFYRHFRSKHDLLFADYDAGLHWFRAALDARPADESIIDSVQAAIFSFPYDVDAV
TKIASLRRGELEPSRIVRHMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARC
VAAAVFGAMEAWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS"
gene 4305757..4306239
/locus_tag="Rv3831"
CDS 4305757..4306239
/codon_start=1
/transl_table=11
/locus_tag="Rv3831"
/product="Hypothetical protein"
/note="Rv3831, (MTCY01A6.38c), len: 160 aa. Hypothetical
unknown protein."
/db_xref="EnsemblGenomes-Gn:Rv3831"
/db_xref="EnsemblGenomes-Tr:CCP46660"
/db_xref="GOA:P96247"
/db_xref="InterPro:IPR021362"
/db_xref="UniProtKB/TrEMBL:P96247"
/protein_id="CCP46660.1"
/translation="MVSLLVHAALGVVVIGWIVSSNPKVFTRPAGGSWFSLPECVYYV
VGIASIALGWYFNIRFVQQYAHGAANPLWGPGSWAEYVRLMFTNPAASSAGQDYTIAN
VILLPLFSTTDGYRRGLRRPWLYFVSSLFTSFAFAFAFYFATIERQHRHERSRATVGA
"
gene complement(4306236..4306811)
/locus_tag="Rv3832c"
CDS complement(4306236..4306811)
/codon_start=1
/transl_table=11
/locus_tag="Rv3832c"
/product="Conserved protein"
/note="Rv3832c, (MTCY01A6.37), len: 191 aa. Conserved
protein, similar in part to various proteins e.g.
Q9XBC9|CZA382.22c putative rRNA methylase from
Amycolatopsis orientalis (259 aa), FASTA scores: opt:
196,E(): 1.3e-05, (38.2% identity in 110 aa overlap);
CAC48459|SMB20059 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymB
(259 aa), FASTA scores: opt: 188, E(): 4.3e-05, (33.8%
identity in 136 aa overlap); Q98FP8|MLL3672 methyl
transferase-like protein from Rhizobium loti
(Mesorhizobium loti) (264 aa), FASTA scores: opt: 180,
E(): 0.00014,(32.05% identity in 156 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3832c"
/db_xref="EnsemblGenomes-Tr:CCP46661"
/db_xref="GOA:P96246"
/db_xref="InterPro:IPR013216"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/TrEMBL:P96246"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46661.1"
/translation="MAMNLLHRRHCSSAGWEKAVANQLLPWALQHVELGPRTLEIGPG
YGATLQALLGLTASLTAVEVDNSMVERLNRRYGQRARIIRGDGTQTGLPDDHFTSVVC
FTMLHHVASAQLQDQLFAEAYRVLQPGGVFAGSDGVPSLPFRLIHIADTYTPIAPADL
PGRLRAVGFTDIHVDVAGARLRWRATKPVAA"
gene 4306867..4307658
/locus_tag="Rv3833"
CDS 4306867..4307658
/codon_start=1
/transl_table=11
/locus_tag="Rv3833"
/product="Transcriptional regulatory protein (probably
AraC-family)"
/note="Rv3833, (MTCY01A6.36c), len: 263 aa. Probable
transcriptional regulator belonging to araC family,
similar to others e.g. Q9KYN4|SC9H11.05 putative
AraC-family transcriptional regulator from Streptomyces
coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42,
(50.45% identity in 232 aa overlap); Q9HXH2|PA3830
probable transcriptional regulator from Pseudomonas
aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26,
(34.85% identity in 238 aa overlap); Q9HX87|PA3927
probable transcriptional regulator from Pseudomonas
aeruginosa (262 aa), FASTA scores: opt: 496, E(): 1.3e-25,
(36.45% identity in 266 aa overlap);
P76241|YEAM_ECOLI|B1790 hypothetical transcriptional
regulator from Escherichia coli strain K12 (273 aa) FASTA
scores: opt: 388, E(): 1.9e-18, (30.5% identity in 223 aa
overlap); etc. Contains probable helix-turn-helix motif
from aa 164-185, Score 2014 (+6.05 SD). Seems to belong to
the AraC/XylS family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3833"
/db_xref="EnsemblGenomes-Tr:CCP46662"
/db_xref="GOA:P96245"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR011051"
/db_xref="InterPro:IPR013096"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR018060"
/db_xref="UniProtKB/TrEMBL:P96245"
/protein_id="CCP46662.1"
/translation="MSENSHHRLATTSLTLPPGARIERHRHPSHQIVYPSAGAVSVTT
HAGTWITPVNRAIWIPAGCWHQHKFHGHTQFHGVALDPQRYRGGPATPTVLAVNPLMR
ELVIACSQADRTDTDEHHRMLAVLQDQLPTTSIREPLWVPSPTDRRLRHACALIADNL
TQPLTLQQIGGRIGVSQRTLSRLFSDELGMTFPQWRTQLRLQHALVLLAERHDVTSVA
SECGWATPSAFIDTYRQAFGHTPGQAAKPMAATRLTRLRRARDRR"
gene complement(4307655..4308914)
/gene="serS"
/locus_tag="Rv3834c"
CDS complement(4307655..4308914)
/codon_start=1
/transl_table=11
/gene="serS"
/locus_tag="Rv3834c"
/product="SERYL-tRNA synthetase SerS (serine--tRNA ligase)
(SERRS) (serine translase)"
/note="Rv3834c, (MTCY01A6.35), len: 419 aa. Probable
serS,seryl-tRNA synthetase, equivalent to
Q9CDC1|SERS|ML0082 putative SERYL-tRNA synthase from
Mycobacterium leprae (417 aa), FASTA scores: opt: 2361,
E(): 8.5e-138, (85.8% identity in 416 aa overlap). Also
highly similar many e.g. Q9ZBX1|SYS_STRCO|SERS|SCD78.28c
from Streptomyces coelicolor (425 aa), FASTA scores: opt:
1594, E(): 1.2e-90,(59.75% identity in 425 aa overlap);
Q9X199|SYS_THEMA|SERS|TM1379 from Thermotoga maritima (425
aa), FASTA scores: opt: 1083, E(): 3.3e-59, (43.3%
identity in 425 aa overlap); P37464|SYS_BACSU|SERS from
Bacillus subtilis (425 aa), FASTA scores: opt: 1015, E():
5e-55,(39.3% identity in 425 aa overlap); etc. Contains
PS00179 Aminoacyl-transfer RNA synthetases class-II
signature 1. Belongs to class-II aminoacyl-tRNA synthetase
family."
/db_xref="EnsemblGenomes-Gn:Rv3834c"
/db_xref="EnsemblGenomes-Tr:CCP46663"
/db_xref="GOA:P9WFT7"
/db_xref="InterPro:IPR002314"
/db_xref="InterPro:IPR002317"
/db_xref="InterPro:IPR006195"
/db_xref="InterPro:IPR010978"
/db_xref="InterPro:IPR015866"
/db_xref="InterPro:IPR033729"
/db_xref="InterPro:IPR042103"
/db_xref="UniProtKB/Swiss-Prot:P9WFT7"
/inference="protein motif:PROSITE:PS00179"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46663.1"
/translation="MIDLKLLRENPDAVRRSQLSRGEDPALVDALLTADAARRAVIST
ADSLRAEQKAASKSVGGASPEERPPLLRRAKELAEQVKAAEADEVEAEAAFTAAHLAI
SNVIVDGVPAGGEDDYAVLDVVGEPSYLENPKDHLELGESLGLIDMQRGAKVSGSRFY
FLTGRGALLQLGLLQLALKLAVDNGFVPTIPPVLVRPEVMVGTGFLGAHAEEVYRVEG
DGLYLVGTSEVPLAGYHSGEILDLSRGPLRYAGWSSCFRREAGSHGKDTRGIIRVHQF
DKVEGFVYCTPADAEHEHERLLGWQRQMLARIEVPYRVIDVAAGDLGSSAARKFDCEA
WIPTQGAYRELTSTSNCTTFQARRLATRYRDASGKPQIAATLNGTLATTRWLVAILEN
HQRPDGSVRVPDALVPFVGVEVLEPVA"
gene 4309047..4310396
/locus_tag="Rv3835"
CDS 4309047..4310396
/codon_start=1
/transl_table=11
/locus_tag="Rv3835"
/product="Conserved membrane protein"
/note="Rv3835, (MTCY01A6.34c), len: 449 aa. Conserved
membrane protein, equivalent to Q9CDC2|ML0081 putative
membrane protein from Mycobacterium leprae (450 aa), FASTA
scores: opt: 2079, E(): 1.8e-74, (69.35% identity in 457
aa overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3835"
/db_xref="EnsemblGenomes-Tr:CCP46664"
/db_xref="GOA:P9WKW5"
/db_xref="InterPro:IPR026004"
/db_xref="UniProtKB/Swiss-Prot:P9WKW5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46664.1"
/translation="MLDAPEQDPVDPGDPASPPHGEAEQPLPGPRWPRALRASATRRA
LLLTALGGLLIAGLVTAIPAVGRAPERLAGYIASNPVPSTGAKINASFNRVASGDCLM
WPDGTPESAAIVSCADEHRFEVAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEA
AVRRYLGTKFDPNSKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVAD
IDQSKVWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEPEQD
GFIKDACTRMTDAYLAPLKLRTTTLTLIYPTLTLPSWSAGSRVVACSIGATLGNGGWA
TLVNSAKGALLINGQPPVPPPDIPEERLNLPPIPLQLPTPRPAPPAQQLPSTPPGTQH
LPAQQPVVTPTRPPESHAPASAAPAETQPPPPDAGAPPATQSPEATPPGPAEPAPAG"
gene 4310401..4310814
/locus_tag="Rv3836"
CDS 4310401..4310814
/codon_start=1
/transl_table=11
/locus_tag="Rv3836"
/product="Conserved hypothetical protein"
/note="Rv3836, (MTCY01A6.33c), len: 137 aa. Conserved
hypothetical protein, highly similar to Q9RKJ2|SCD25.30
hypothetical 13.1 KDA protein from Streptomyces coelicolor
(116 aa), FASTA scores: opt: 395, E(): 3.3e-19, (54.4%
identity in 114 aa overlap); and similar to
CAC47753|SMC0379 conserved hypothetical protein from
Rhizobium meliloti (Sinorhizobium meliloti) (144 aa) FASTA
scores: opt: 194, E(): 6e-06, (33.05% identity in 109 aa
overlap); and Q98E37|MLL4425 hypothetical protein from
Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA
scores: opt: 184, E(): 3.7e-05, (29.75% identity in 121 aa
overlap). Contains PS00142 Neutral zinc
metallopeptidases,zinc-binding region signature."
/db_xref="EnsemblGenomes-Gn:Rv3836"
/db_xref="EnsemblGenomes-Tr:CCP46665"
/db_xref="InterPro:IPR010428"
/db_xref="InterPro:IPR038555"
/db_xref="UniProtKB/TrEMBL:P96242"
/inference="protein motif:PROSITE:PS00142"
/protein_id="CCP46665.1"
/translation="MTVRMDPQRFDELVSDALDLIPPELADAMDNVVVLVANRHPQHE
NLLGQYEGVALTERGSDYAGSLPDAITIYREALLDACDSEDEVVDQVAITVIHEVAHH
FGIDDERLDQLGWRDEPAPGRGNPDLSAPDAMNGP"
gene complement(4311009..4311707)
/locus_tag="Rv3837c"
CDS complement(4311009..4311707)
/codon_start=1
/transl_table=11
/locus_tag="Rv3837c"
/product="Probable phosphoglycerate mutase
(phosphoglyceromutase) (phosphoglycerate phosphomutase)"
/note="Rv3837c, (MTCY01A6.32), len: 232 aa. Probable
phosphoglycerate mutase, equivalent to Q9CDC3|ML0079
putative phosphoglycerate mutase from Mycobacterium leprae
(231 aa), FASTA scores: opt: 1116, E(): 7.3e-66, (71.55%
identity in 232 aa overlap). Also similar to others e.g.
Q9ZAX0|PGM 2,3-PDG dependent phosphoglycerate mutase from
Amycolatopsis methanolica (205 aa), FASTA scores: opt:
474,E(): 6.4e-24, (41.85% identity in 203 aa overlap);
Q9F3Q7|SC10F4.03 putative isomerase from Streptomyces
coelicolor (224 aa) FASTA scores: opt: 349, E():
1e-15,(33.2% identity in 223 aa overlap);
Q9RDL0|SCC123.14c putative phosphoglycerate mutase from
Streptomyces coelicolor (223 aa), FASTA scores: opt: 256,
E(): 1.2e-09,(34.0% identity in 203 aa overlap);
Q9RVD2|DR1097 putative phosphoglycerate mutase from
Deinococcus radiodurans (232 aa), FASTA scores: opt: 201,
E(): 5.1e-06, (31.45% identity in 175 aa overlap); etc.
Also similar to P71724|Rv2419c|MTCY428.28|MTCY253.01
hypothetical 24.2 KDA protein from Mycobacterium
tuberculosis (223 aa), FASTA scores: opt: 210, E():
1.3e-06, (32.0% identity in 172 aa overlap). Contains
PS00175 Phosphoglycerate mutase family phosphohistidine
signature."
/db_xref="EnsemblGenomes-Gn:Rv3837c"
/db_xref="EnsemblGenomes-Tr:CCP46666"
/db_xref="InterPro:IPR013078"
/db_xref="InterPro:IPR029033"
/db_xref="UniProtKB/TrEMBL:P96241"
/inference="protein motif:PROSITE:PS00175"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46666.1"
/translation="MSGRLVLLRHGQSYGNVERRLDTLPPGTALTPLGRDQARAFARS
GCRRPALLAHSVAIRAYQTAAVVAAELDMVAHEVAGIHEVQVGELENRNDDEAVAEFN
ATYSRWHRGELDVPLPGGETANDVLDRYLPVLADLRMRYLDDGDWDGDIVVVSHSAAI
RLAAAVLAGVDGNFVLDNHLENVESVVLAPITDGRWSCVQWGLRKPPFCPDPAEAAAS
PVTHAVTSSTDPMG"
gene complement(4311704..4312669)
/gene="pheA"
/locus_tag="Rv3838c"
CDS complement(4311704..4312669)
/codon_start=1
/transl_table=11
/gene="pheA"
/locus_tag="Rv3838c"
/product="Prephenate dehydratase PheA"
/note="Rv3838c, (MTCY01A6.31), len: 321 aa.
PheA,prephenate dehydratase (see citation below),
equivalent to Q9CDC4|PHEA|ML0078 putative prephenate
dehydratase from Mycobacterium leprae (322 aa), FASTA
scores: opt: 1690,E(): 1.3e-93, (84.25% identity in 311 aa
overlap). Also highly similar to others e.g.
P10341|PHEA_CORGL from Corynebacterium glutamicum
(Brevibacterium flavum) (315 aa), FASTA scores: opt: 843,
E(): 4e-43, (45.8% identity in 308 aa overlap);
Q9ZBX0|SCD78.29c from Streptomyces coelicolor (310 aa),
FASTA scores: opt: 820, E(): 9.2e-42,(46.45% identity in
312 aa overlap); Q44104|PHEA_AMYME|PDT from Amycolatopsis
methanolica (304 aa), FASTA scores: opt: 707, E():
4.9e-35, (45.7% identity in 313 aa overlap); etc. Contains
PS00858 Prephenate dehydratase signature 2."
/db_xref="EnsemblGenomes-Gn:Rv3838c"
/db_xref="EnsemblGenomes-Tr:CCP46667"
/db_xref="GOA:P9WIC3"
/db_xref="InterPro:IPR001086"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR008242"
/db_xref="InterPro:IPR018528"
/db_xref="UniProtKB/Swiss-Prot:P9WIC3"
/inference="protein motif:PROSITE:PS00858"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46667.1"
/translation="MVRIAYLGPEGTFTEAALVRMVAAGLVPETGPDALQRMPVESAP
AALAAVRDGGADYACVPIENSIDGSVLPTLDSLAIGVRLQVFAETTLDVTFSIVVKPG
RNAADVRTLAAFPVAAAQVRQWLAAHLPAADLRPAYSNADAARQVADGLVDAAVTSPL
AAARWGLAALADGVVDESNARTRFVLVGRPGPPPARTGADRTSAVLRIDNQPGALVAA
LAEFGIRGIDLTRIESRPTRTELGTYLFFVDCVGHIDDEAVAEALKAVHRRCADVRYL
GSWPTGPAAGAQPPLVDEASRWLARLRAGKPEQTLVRPDDQGAQA"
gene 4312765..4313541
/locus_tag="Rv3839"
CDS 4312765..4313541
/codon_start=1
/transl_table=11
/locus_tag="Rv3839"
/product="Conserved hypothetical protein"
/note="Rv3839, (MTCY01A6.30c), len: 258 aa. Conserved
hypothetical protein, similar in part to
Q9RD78|SCF43.10cfrom hypothetical 25.8 KDA protein
Streptomyces coelicolor (241 aa), FASTA scores: opt:
270,E(): 3.2e-10, (33.45% identity in 272 aa overlap); and
O00320|F25451_2 hypothetical protein from Homo sapiens
(Human) (339 aa), FASTA scores: opt: 126, E():
0.77,(28.75% identity in 240 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3839"
/db_xref="EnsemblGenomes-Tr:CCP46668"
/db_xref="InterPro:IPR037119"
/db_xref="UniProtKB/TrEMBL:P96239"
/protein_id="CCP46668.1"
/translation="MPPLTSLAPTTAERIRSACARAGGALLVVEREDPVPVPIHHLLY
DGSFAVAVPVDRGEVSGSQALLELTDYAPLPVREPVRSLVWIRGCLHQIPPAELVETL
DLIATDNPNPALLQVETPRPGPADAAETRYTMQRLEIESVVVTDATGAEPVTVADLLA
ARPDPFCEIESTLLWHLATAHDDVVARLVSRLPAPLRRGQIRPLGLDRYGVRFRIEAR
DGDRDIRLPFHKPVDDMTGLSQAIRVLMGCPFRNGLRARR"
gene 4313567..4313980
/locus_tag="Rv3840"
CDS 4313567..4313980
/codon_start=1
/transl_table=11
/locus_tag="Rv3840"
/product="Possible transcriptional regulatory protein"
/note="Rv3840, (MTCY01A6.29c), len: 137 aa. Possible
transcriptional regulator, highly similar in part to PSR
proteins (penicillin binding protein repressors) e.g.
Q47828|PSR PSR protein from Enterococcus hirae (293 aa)
FASTA scores: opt: 221, E(): 2.2e-07, (41.65% identity in
108 aa overlap); O86213|PSRFM PSRFM protein (fragment)
from Enterococcus hirae (171 aa), FASTA scores: opt: 202,
E(): 2.4e-06, (40.75% identity in 108 aa overlap);
Q47865|PSR penicillin binding protein repressor from
Enterococcus hirae (148 aa), FASTA scores: opt: 201, E():
2.5e-06,(51.65% identity in 60 aa overlap); etc. Also
highly similar in part to other transcriptional regulators
e.g. BAB57524|MSRR peptide methionine sulfoxide reductase
regulator from Staphylococcus aureus subsp. aureus Mu50
(327 aa), FASTA scores: opt: 195, E(): 1.2e-05, (36.7%
identity in 109 aa overlap); Q99Q02|MSRR|SA1195 peptide
methionine sulfoxide reductase regulator from
Staphylococcus aureus subsp. aureus N315, and
Staphylococcus aureus (327 aa), FASTA scores: opt:
192,E(): 1.9e-05, (36.7% identity in 109 aa overlap);
Q9K6Q8|LYTR|BH3670 attenuator for lytabc and LYTR
expression from Bacillus halodurans (304 aa), FASTA
scores: opt: 171, E(): 0.00041, (34.5% identity in 113 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3840"
/db_xref="EnsemblGenomes-Tr:CCP46669"
/db_xref="InterPro:IPR004474"
/db_xref="UniProtKB/TrEMBL:P96238"
/protein_id="CCP46669.1"
/translation="MAGCIQRFSHVRCLGPGLASDNPTTLISIPRDSYVPIPGHGRDK
INAAFALGGGRLLTQTVELATGLHLDHYAEVGFSEFADLVDAFDPLAGVDLPAGCQTL
DGRAALGYVRTRATPRADLEGSDVPVPAAAFETQP"
gene 4314178..4314723
/gene="bfrB"
/locus_tag="Rv3841"
CDS 4314178..4314723
/codon_start=1
/transl_table=11
/gene="bfrB"
/locus_tag="Rv3841"
/product="Bacterioferritin BfrB"
/note="Rv3841, (MTCY01A6.28c), len: 181 aa.
bfrB,bacterioferritin, similar to other ferritin or
hypothetical proteins e.g. O26261|MTH158|RSGA ferritin
like protein from Methanothermobacter thermautotrophicus
(171 aa), FASTA scores: opt: 277, E(): 6.6e-11, (30.1%
identity in 166 aa overlap); Q99SZ3|SA1709 hypothetical
protein from Staphylococcus aureus subsp. aureus N315 (166
aa), FASTA scores: opt: 275, E(): 8.7e-11, (33.35%
identity in 156 aa overlap); Q9X0L2|TM1128 ferritin from
Thermotoga maritima (164 aa), FASTA scores: opt: 247, E():
5.3e-09, (25.65% identity in 156 aa overlap);
Q9KDT7|BH1124 ferritin from Bacillus halodurans (169 aa),
FASTA scores: opt: 246, E(): 6.3e-09, (28.95% identity in
152 aa overlap); O29424|AF0834 putative ferritin from
Archaeoglobus fulgidu (169 aa),FASTA scores: opt: 246,
E(): 6.3e-09, (28.95% identity in 152 aa overlap); etc.
Also shows similarity with Rv1876|MTCY180.42|BFRA probable
bacterioferritin from Mycobacterium tuberculosis (159 aa).
Seems belong to the bacterioferritin family."
/db_xref="EnsemblGenomes-Gn:Rv3841"
/db_xref="EnsemblGenomes-Tr:CCP46670"
/db_xref="GOA:P9WNE5"
/db_xref="InterPro:IPR001519"
/db_xref="InterPro:IPR008331"
/db_xref="InterPro:IPR009040"
/db_xref="InterPro:IPR009078"
/db_xref="InterPro:IPR012347"
/db_xref="InterPro:IPR041719"
/db_xref="PDB:3QD8"
/db_xref="PDB:3UNO"
/db_xref="UniProtKB/Swiss-Prot:P9WNE5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46670.1"
/translation="MTEYEGPKTKFHALMQEQIHNEFTAAQQYVAIAVYFDSEDLPQL
AKHFYSQAVEERNHAMMLVQHLLDRDLRVEIPGVDTVRNQFDRPREALALALDQERTV
TDQVGRLTAVARDEGDFLGEQFMQWFLQEQIEEVALMATLVRVADRAGANLFELENFV
AREVDVAPAASGAPHAAGGRL"
gene complement(4314738..4315562)
/gene="glpQ1"
/locus_tag="Rv3842c"
CDS complement(4314738..4315562)
/codon_start=1
/transl_table=11
/gene="glpQ1"
/locus_tag="Rv3842c"
/product="Probable glycerophosphoryl diester
phosphodiesterase GlpQ1 (glycerophosphodiester
phosphodiesterase)"
/note="Rv3842c, (MTCY01A6.27), len: 274 aa. Probable
glpQ1,glycerophosphoryl diester phosphodiesterase,
equivalent to Q9CDC5|GLPQ|ML0074 putative
glycerophosphoryl diester phosphodiesterase from
Mycobacterium leprae (271 aa), FASTA scores: opt: 1635,
E(): 1.9e-100, (88.85% identity in 269 aa overlap). Also
highly similar to others e.g. CAC44700|SCBAC25E3.13c
putative phosphodiesterase from Streptomyces coelicolor
(275 aa), FASTA scores: opt: 413,E(): 5.7e-20, (48.05%
identity in 258 aa overlap); P37965|GLPQ_BACSU
glycerophosphoryl diester phosphodiesterase from Bacillus
subtilis (293 aa), FASTA scores: opt: 405, E(): 2e-19,
(31.3% identity in 249 aa overlap); Q99VC9|GLPQ|SA0820
glycerophosphoryl diester phosphodiesterase from
Staphylococcus aureus subsp. aureus N315 (309 aa) FASTA
scores: opt: 341, E(): 3.5e-15, (29.3% identity in 273 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3842c"
/db_xref="EnsemblGenomes-Tr:CCP46671"
/db_xref="GOA:P9WMU3"
/db_xref="InterPro:IPR017946"
/db_xref="InterPro:IPR030395"
/db_xref="UniProtKB/Swiss-Prot:P9WMU3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46671.1"
/translation="MTWADEVLAGHPFVVAHRGASAARPEHTLAAYDLALKEGADGVE
CDVRLTRDGHLVCVHDRRLDRTSTGAGLVSTMTLAQLRELEYGAWHDSWRPDGSHGDT
SLLTLDALVSLVLDWHRPVKIFVETKHPVRYGSLVENKLLALLHRFGIAAPASADRSR
AVVMSFSAAAVWRIRRAAPLLPTVLLGKTPRYLTSSAATAVGATAVGPSLPALKEYPQ
LVDRSAAQGRAVYCWNVDEYEDIDFCREVGVAWIGTHHPGRTKAWLEDGRANGTTR"
gene 4314798..4314891
/gene="ncrMT3949"
ncRNA 4314798..4314891
/gene="ncrMT3949"
/product="Fragment of putative small regulatory RNA"
/note="ncrMT3949, fragment of putative small regulatory
RNA (See Pelly et al., 2012), cloned from M. tuberculosis
CDC1551; supported by RNA-seq in H37Rv (unpublished
data)."
/ncRNA_class="other"
gene complement(4315568..4316596)
/locus_tag="Rv3843c"
CDS complement(4315568..4316596)
/codon_start=1
/transl_table=11
/locus_tag="Rv3843c"
/product="Probable conserved transmembrane protein"
/note="Rv3843c, (MTCY01A6.26), len: 342 aa. Probable
conserved transmembrane protein, equivalent to
Q9CDC6|ML0073 putative membrane protein from Mycobacterium
leprae (344 aa), FASTA scores: opt: 1420, E():
2.6e-68,(63.05% identity in 349 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3843c"
/db_xref="EnsemblGenomes-Tr:CCP46672"
/db_xref="GOA:P96235"
/db_xref="InterPro:IPR025565"
/db_xref="UniProtKB/TrEMBL:P96235"
/protein_id="CCP46672.1"
/translation="MIQVCSQCGTGWNVRERQRVWCPRCRGMLLAPLADMPAEARWRT
PARPQVPTASDTRRTPPRLPPGFRWIAVRPGAAPPPRHGPRLRGPTPRYAGIPRWGLT
DHVDQAPVPASAKAGPSPAAVRTTLLVSLLVFSIAVVVFVVRYVLLVINRNTLLNSVV
ASASVWLGVLVSLAAIAAAGTTIVLLVRWLVARRAAAFMHQGLPERRSARELWAGCLL
PMVNLLWAPLYVIELALVEDRYTRLRRPIVVWWIVWIVSNAISMFAFATSWVTDAQGI
ANNTTMMVLAYLCAAAAVAAAARVFEGFEQKPVERPAHRWVVVNTDGRSAPASSVAVE
LDGQEPAA"
gene 4317073..4317165
/gene="MTS2975"
ncRNA 4317073..4317165
/gene="MTS2975"
/product="Putative small regulatory RNA"
/note="MTS2975, putative small regulatory RNA (See Arnvig
et al., 2011), ends not mapped, ~100 bp band detected by
Northern blot."
/ncRNA_class="other"
gene 4318775..4319266
/locus_tag="Rv3844"
CDS 4318775..4319266
/codon_start=1
/transl_table=11
/locus_tag="Rv3844"
/product="Possible transposase"
/note="Rv3844, (MTCY01A6.25), len: 163 aa. Possible
transposase, identical to P96234|Rv3348|MTV004.04 putative
transposase from Mycobacterium tuberculosis. Also some
similarity with others e.g. N-terminal part of
P19834|YI11_STRCL insertion element IS116 hypothetical
44.8 KDA protein from Streptomyces clavuligerus (399 aa)
FASTA scores: opt: 146, E(): 0.017, (29.1% identity in 158
aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3844"
/db_xref="EnsemblGenomes-Tr:CCP46673"
/db_xref="GOA:P96234"
/db_xref="InterPro:IPR002525"
/db_xref="UniProtKB/TrEMBL:P96234"
/protein_id="CCP46673.1"
/translation="MTAENPGRSRRTLVGIDAAITACHHIAIRDDVGARSIRFSVEPT
LAGLRTLTDKLSGYDDIDATVEPTSMTWLPLTIAVENAGDTMHMAGARHCARLRGAIV
GKSKSDVIDAEVLTRASEVFDLTPLTLPTPAQLALRRSVIRRAGAVIDANRSWRRLMS
LAR"
gene 4319281..4319640
/locus_tag="Rv3845"
CDS 4319281..4319640
/codon_start=1
/transl_table=11
/locus_tag="Rv3845"
/product="Hypothetical protein"
/note="Rv3845, (MTCY01A6.24c), len: 119 aa. Hypothetical
unknown protein. Contains PS01137 Hypothetical
YBL055c/yjjV family signature 1."
/db_xref="EnsemblGenomes-Gn:Rv3845"
/db_xref="EnsemblGenomes-Tr:CCP46674"
/db_xref="GOA:P96233"
/db_xref="UniProtKB/TrEMBL:P96233"
/inference="protein motif:PROSITE:PS01137"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46674.1"
/translation="MDRVRRVVTDRDSGAGALARHPLAGRRTDPQLAAFYHRLMTTQR
HCHTQATIAVARKLAERTRVTITTGRPYQLRDTNGDPVTARGAKELIDAHYHVDTRTH
PHNRAHTDTMQNSKPAR"
gene 4320704..4321327
/gene="sodA"
/gene_synonym="sod"
/gene_synonym="sodB"
/locus_tag="Rv3846"
CDS 4320704..4321327
/codon_start=1
/transl_table=11
/gene="sodA"
/gene_synonym="sod"
/gene_synonym="sodB"
/locus_tag="Rv3846"
/product="Superoxide dismutase [FE] SodA"
/note="Rv3846, (MTCY01A6.22c), len: 207 aa. SodA
(alternate gene names: sodB, sod), superoxide dismutase
(see citations below), equivalent to many e.g.
P47201|SODM_MYCAV|soda|sod from Mycobacterium avium (206
aa), FASTA scores: opt: 1210,E(): 1.8e-73, (82.5% identity
in 206 aa overlap); Q9F9R1|sod from Mycobacterium
paratuberculosis (207 aa),FASTA scores: opt: 1207, E():
2.9e-73, (81.65% identity in 207 aa overlap);
O86165|SODM_MYCLP|soda|sod from Mycobacterium lepraemurium
(206 aa), FASTA scores: opt: 1204, E(): 4.5e-73, (82.05%
identity in 206 aa overlap); P13367|SODM_MYCLE|soda|ML0072
from Mycobacterium leprae (206 aa), FASTA scores: opt:
1169, E(): 9.6e-71, (80.5% identity in 205 aa overlap);
etc. Contains PS00088 Manganese and iron superoxide
dismutases signature. Belongs to the iron/manganese
superoxide dismutase family. Although found
extracellularly, no signal sequence is present. An
alternative secretory pathway may be used."
/db_xref="EnsemblGenomes-Gn:Rv3846"
/db_xref="EnsemblGenomes-Tr:CCP46675"
/db_xref="GOA:P9WGE7"
/db_xref="InterPro:IPR001189"
/db_xref="InterPro:IPR019831"
/db_xref="InterPro:IPR019832"
/db_xref="InterPro:IPR019833"
/db_xref="InterPro:IPR036314"
/db_xref="InterPro:IPR036324"
/db_xref="PDB:1GN2"
/db_xref="PDB:1GN3"
/db_xref="PDB:1GN4"
/db_xref="PDB:1GN6"
/db_xref="PDB:1IDS"
/db_xref="UniProtKB/Swiss-Prot:P9WGE7"
/inference="protein motif:PROSITE:PS00088"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46675.1"
/translation="MAEYTLPDLDWDYGALEPHISGQINELHHSKHHATYVKGANDAV
AKLEEARAKEDHSAILLNEKNLAFNLAGHVNHTIWWKNLSPNGGDKPTGELAAAIADA
FGSFDKFRAQFHAAATTVQGSGWAALGWDTLGNKLLIFQVYDHQTNFPLGIVPLLLLD
MWEHAFYLQYKNVKVDFAKAFWNVVNWADVQSRYAAATSQTKGLIFG"
gene 4321538..4322071
/locus_tag="Rv3847"
CDS 4321538..4322071
/codon_start=1
/transl_table=11
/locus_tag="Rv3847"
/product="Hypothetical protein"
/note="Rv3847, (MTCY01A6.21c), len: 177 aa. Conserved
hypothetical protein, equivalent to Q9CDC7|ML0071
hypothetical protein from Mycobacterium leprae (177 aa)
FASTA scores: opt: 1149, E(): 1.6e-64, (96.6% identity in
177 aa overlap); and Q9F9R0 hypothetical 18.5 KDA protein
from Mycobacterium paratuberculosis (177 aa), FASTA
scores: opt: 1139, E(): 6.8e-64, (96.6% identity in 177 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3847"
/db_xref="EnsemblGenomes-Tr:CCP46676"
/db_xref="UniProtKB/TrEMBL:P96230"
/protein_id="CCP46676.1"
/translation="MGTGSGGPIGVSPFHSRGALKGFVISGRWPDSTKEWAQLLMVAV
RVASLPGLLSTTTVFGAREELPDEPEPGTVGLVLAEGTVFGESAIQPGYFADHQPPAL
LMLHPPSETTPSLPECTGAASGCVLLPGLPYLGLEHRAAWVEAEADGTITSMVSRVGV
DPISHPDTAILAMLLAA"
gene 4322326..4323234
/locus_tag="Rv3848"
CDS 4322326..4323234
/codon_start=1
/transl_table=11
/locus_tag="Rv3848"
/product="Probable conserved transmembrane protein"
/note="Rv3848, (MTCY01A6.20c), len: 302 aa. Probable
conserved transmembrane protein, similar to hypothetical
(transmembrane) proteins e.g. Q9HVG2|PA4629 hypothetical
protein from Pseudomonas aeruginosa (192 aa), FASTA
scores: opt: 304, E(): 5.3e-11, (35.05% identity in 174 aa
overlap); Q9A5S7|CC2370 hypothetical protein from
Caulobacter crescentus (207 aa), FASTA scores: opt:
285,E(): 7.4e-10, (29.9% identity in 184 aa overlap);
Q9KY43|SCC8A.05c putative integral membrane protein from
Streptomyces coelicolor (193 aa), FASTA scores: opt:
245,E(): 1.6e-07, (32.8% identity in 195 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3848"
/db_xref="EnsemblGenomes-Tr:CCP46677"
/db_xref="GOA:P96229"
/db_xref="InterPro:IPR001727"
/db_xref="UniProtKB/TrEMBL:P96229"
/protein_id="CCP46677.1"
/translation="MLAATLLSLGAVFLAELGDRSQLITMTYTLRYRWWVVLTGVAIA
AFTVHGVAVAIGHFLGSTVPARPAACVSAIAFLIFAVWVWREDTASDSETSPTAAEPR
LALFTVVSSFALAELGDKTTLATVTLASDHHWAGVWIGTTLGMILADGLAIGAGLLLH
RRLPERLLQVLTGLLFLLFGLWLLFDDALGFRSVAIAVTAAVVLAAATTAVSVRVAQT
RRRRPTAAATPEDDSTRPERSSVAPGHPGSILLPLPEVSLRGRRPPSGSPDERCADPG
SKGGSRRISVGCWLPGVGRIRPTRSS"
gene 4323499..4323897
/gene="espR"
/locus_tag="Rv3849"
CDS 4323499..4323897
/codon_start=1
/transl_table=11
/gene="espR"
/locus_tag="Rv3849"
/product="ESX-1 transcriptional regulatory protein EspR"
/note="Rv3849, (MTCY01A6.19c), len: 132 aa. EspR, ESX-1
secreted protein regulator (See Raghavan et al.,
2008),equivalent to Q9CDC9|ML0069 hypothetical protein
from Mycobacterium leprae (132 aa) FASTA scores: opt: 724,
E(): 8.7e-41, (83.95% identity in 131 aa overlap). A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3849"
/db_xref="EnsemblGenomes-Tr:CCP46678"
/db_xref="GOA:P9WJB7"
/db_xref="PDB:3QF3"
/db_xref="PDB:3QWG"
/db_xref="PDB:3QYX"
/db_xref="PDB:3R1F"
/db_xref="PDB:4NDW"
/db_xref="UniProtKB/Swiss-Prot:P9WJB7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46678.1"
/translation="MSTTFAARLNRLFDTVYPPGRGPHTSAEVIAALKAEGITMSAPY
LSQLRSGNRTNPSGATMAALANFFRIKAAYFTDDEYYEKLDKELQWLCTMRDDGVRRI
AQRAHGLPSAAQQKVLDRIDELRRAEGIDA"
gene 4324015..4324671
/locus_tag="Rv3850"
CDS 4324015..4324671
/codon_start=1
/transl_table=11
/locus_tag="Rv3850"
/product="Conserved protein"
/note="Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved
protein, equivalent to Q9CDD0|ML0068 hypothetical protein
from Mycobacterium leprae (238 aa) FASTA scores: opt:
1071,E(): 7.2e-55, (78.35% identity in 217 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3850"
/db_xref="EnsemblGenomes-Tr:CCP46679"
/db_xref="GOA:P96227"
/db_xref="UniProtKB/TrEMBL:P96227"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46679.1"
/translation="MGLFGKRKSRATRRAEARAIKARAKLEAKLSAKNEARRIKAAQR
AESKALKAQLKARRDSDRAALKVAEAELKVAREGKLLSPTRIRRLLTVSRLLAPILTP
VIYRAAMAARGLIDQRRADQLGVPLAQIGRFSGHGARLSARVGGAERSLRMVQEKKPK
DVETKQFVSAVTNRLTDLSAAVAAAEHMPAKRRRTAHSAISSQLDGIEADLMARLGLT
"
gene 4324683..4324967
/locus_tag="Rv3851"
CDS 4324683..4324967
/codon_start=1
/transl_table=11
/locus_tag="Rv3851"
/product="Possible membrane protein"
/note="Rv3851, (MTCY01A6.17c), len: 94 aa. Possible
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv3851"
/db_xref="EnsemblGenomes-Tr:CCP46680"
/db_xref="GOA:P96226"
/db_xref="UniProtKB/TrEMBL:P96226"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46680.1"
/translation="MTAIGMSHPPRVHRRVGGQRTALTAGIGLLLAALVLTTIANPPA
AFAHTAQLSTATPAPAVAATDANDVPTWPFVVGTVAAVAVAALWAVRRGR"
gene 4325074..4325478
/gene="hns"
/locus_tag="Rv3852"
CDS 4325074..4325478
/codon_start=1
/transl_table=11
/gene="hns"
/locus_tag="Rv3852"
/product="Possible histone-like protein Hns"
/note="Rv3852, (MTCY01A6.16c), len: 134 aa. Possible
hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067
histone-like protein from Mycobacterium leprae (121
aa),FASTA scores: opt: 341, E(): 4.3e-09, (51.5% identity
in 134 aa overlap). Shows some similarity with other
histone-like proteins e.g. O65795|HIS1 histone H1 from
Triticum aestivum (Wheat) (288 aa), FASTA scores: opt:
183,E(): 0.091, (34.85% identity in 109 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3852"
/db_xref="EnsemblGenomes-Tr:CCP46681"
/db_xref="GOA:I6YHB0"
/db_xref="UniProtKB/TrEMBL:I6YHB0"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46681.1"
/translation="MPDPQDRPDSEPSDASTPPAKKLPAKKAAKKAPARKTPAKKAPA
KKTPAKGAKSAPPKPAEAPVSLQQRIETNGQLAAAAKDAAAQAKSTVEGANDALARNA
SVPAPSHSPVPLIVAVTLSLLALLLIRQLRRR"
gene 4325495..4325968
/gene="rraA"
/gene_synonym="menG"
/locus_tag="Rv3853"
CDS 4325495..4325968
/codon_start=1
/transl_table=11
/gene="rraA"
/gene_synonym="menG"
/locus_tag="Rv3853"
/product="Regulator of RNase E activity a RraA"
/note="Rv3853, (MTCY01A6.15c), len: 157 aa. RraA,
regulator of RNase E activity A, equivalent to
Q9CDD2|RRAA|ML0066 rraA, regulator of RNase E activity a
from Mycobacterium leprae (157 aa) FASTA scores: opt: 896,
E(): 1.3e-49,(87.1% identity in 155 aa overlap). Also
similar to others e.g.
P32165|RRAA_ECOLI|B3929|Z5476|ECS4856 from Escherichia
coli strain K12 (161 aa), FASTA scores: opt: 428, E():
3.7e-20, (45.65% identity in 149 aa overlap); etc.
Previously known as menG."
/db_xref="EnsemblGenomes-Gn:Rv3853"
/db_xref="EnsemblGenomes-Tr:CCP46682"
/db_xref="GOA:P9WGY3"
/db_xref="InterPro:IPR005493"
/db_xref="InterPro:IPR010203"
/db_xref="InterPro:IPR036704"
/db_xref="PDB:1NXJ"
/db_xref="UniProtKB/Swiss-Prot:P9WGY3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46682.1"
/translation="MAISFRPTADLVDDIGPDVRSCDLQFRQFGGRSQFAGPISTVRC
FQDNALLKSVLSQPSAGGVLVIDGAGSLHTALVGDVIAELARSTGWTGLIVHGAVRDA
AALRGIDIGIKALGTNPRKSTKTGAGERDVEITLGGVTFVPGDIAYSDDDGIIVV"
gene complement(4326004..4327473)
/gene="ethA"
/gene_synonym="aka"
/gene_synonym="etaA"
/locus_tag="Rv3854c"
CDS complement(4326004..4327473)
/codon_start=1
/transl_table=11
/gene="ethA"
/gene_synonym="aka"
/gene_synonym="etaA"
/locus_tag="Rv3854c"
/product="Monooxygenase EthA"
/note="Rv3854c, (MTCY01A6.14), len: 489 aa. EthA
(alternate gene names: aka, etaA), monooxygenase required
for activation of the pro-drug ethionamide (see citations
below), highly similar to other monooxygenases e.g.
Q9A588|CC2569 monooxygenase (flavin-binding family) from
Caulobacter crescentus (498 aa), FASTA scores: opt:
1959,E(): 2.9e-114, (57.6% identity in 481 aa overlap);
Q9RZT0|DRB0033 arylesterase/monoxygenase from Deinococcus
radiodurans (833 aa), FASTA scores: opt: 1771, E():
2.2e-102, (53.75% identity in 480 aa overlap);
Q9A8K5|CC1348 monooxygenase (flavin-binding family) from
Caulobacter crescentus (499 aa), FASTA scores: opt:
1385,E(): 1.4e-78, (43.2% identity in 486 aa overlap);
etc. Also highly similar to others from Mycobacterium
tuberculosis e.g. O53300|Rv3083|MTV013.04 monoxygenase
(495 aa) FASTA scores: opt: 1692, E(): 1.1e-97, (49.7%
identity in 489 aa overlap); O53762|Rv0565c|MTV039.03c
putative monoxygenase (486 aa), FASTA scores: opt: 1571,
E(): 3.7e-90, (49.05% identity in 471 aa overlap);
O69708|Rv3741c|MTV025.089c possible oxidoreductase
(probably second part of a two component monooxygenase)
(224 aa), FASTA scores: opt: 542,E(): 1.7e-26, (50.0%
identity in 162 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3854c"
/db_xref="EnsemblGenomes-Tr:CCP46683"
/db_xref="GOA:P9WNF9"
/db_xref="InterPro:IPR020946"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WNF9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46683.1"
/translation="MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGT
WDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHH
KVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGP
IIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDR
DGIAEKLNRWLPETMAYTAVRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGY
DVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELP
ADIIITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWT
LKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDELPKQG
SRTPWRLNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV"
gene 4327549..4328199
/gene="ethR"
/gene_synonym="aka"
/gene_synonym="etaR"
/locus_tag="Rv3855"
CDS 4327549..4328199
/codon_start=1
/transl_table=11
/gene="ethR"
/gene_synonym="aka"
/gene_synonym="etaR"
/locus_tag="Rv3855"
/product="Transcriptional regulatory repressor protein
(TetR-family) EthR"
/note="Rv3855, (MTCY01A6.13c), len: 216 aa. EthR
(alternate gene names: aka, etaR), regulatory protein TetR
family,involved in ethionamide sensitivity/resistance,
negatively controls neighbouring ethA (Rv3854c,
MTCY01A6.14; alternate gene names: aka etaA) (see
citations below). Equivalent to Q9CDD3|ML0064 putative
transcriptional regulator from Mycobacterium leprae (214
aa), FASTA scores: opt: 1017,E(): 7e-62, (77.0% identity
in 213 aa overlap). Also similar to other transcriptional
regulator e.g. Q9S1R1|SCJ9A.09 putative TetR-family
transcriptional regulator from Streptomyces coelicolor
(204 aa), FASTA scores: opt: 305, E(): 1.2e-13, (34.5%
identity in 200 aa overlap); Q9KYT9|SCE22.24 putative
TetR-family transcriptional regulator (fragment) from
Streptomyces coelicolor (244 aa), FASTA scores: opt: 179,
E(): 4.9e-05,(35.5% identity in 93 aa overlap);
Q9RUK2|DR1384 transcriptional regulator (TetR family) from
Deinococcus radiodurans (196 aa), FASTA scores: opt: 167,
E(): 0.00026,(41.75% identity in 79 aa overlap); etc. Also
similar to P95100|Rv3058c|MTCY22D7.23 hypothetical 23.8
KDA protein from Mycobacterium tuberculosis (216 aa) FASTA
scores: opt: 261, E(): 1.2e-10, (31.65% identity in 221 aa
overlap); and O08377|Rv1534|MTCY07A7A.03 hypothetical 24.5
KDA protein from Mycobacterium tuberculosis (225 aa),
FASTA scores: opt: 164, E(): 0.00047, (25.5% identity in
248 aa overlap). Contains helix-turn-helix motif at aa
45-66, Score 1320 (+3.68 SD). Belongs to the TetR/AcrR
family of transcriptional regulators."
/db_xref="EnsemblGenomes-Gn:Rv3855"
/db_xref="EnsemblGenomes-Tr:CCP46684"
/db_xref="GOA:P9WMC1"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="PDB:1T56"
/db_xref="PDB:1U9N"
/db_xref="PDB:1U9O"
/db_xref="PDB:3G1L"
/db_xref="PDB:3G1M"
/db_xref="PDB:3G1O"
/db_xref="PDB:3O8G"
/db_xref="PDB:3O8H"
/db_xref="PDB:3Q0U"
/db_xref="PDB:3Q0V"
/db_xref="PDB:3Q0W"
/db_xref="PDB:3Q3S"
/db_xref="PDB:3QPL"
/db_xref="PDB:3SDG"
/db_xref="PDB:3SFI"
/db_xref="PDB:3TP0"
/db_xref="PDB:3TP3"
/db_xref="PDB:4DW6"
/db_xref="PDB:4M3B"
/db_xref="PDB:4M3D"
/db_xref="PDB:4M3E"
/db_xref="PDB:4M3G"
/db_xref="PDB:5EYR"
/db_xref="PDB:5EZG"
/db_xref="PDB:5EZH"
/db_xref="PDB:5F04"
/db_xref="PDB:5F08"
/db_xref="PDB:5F0C"
/db_xref="PDB:5F0F"
/db_xref="PDB:5F0H"
/db_xref="PDB:5F1J"
/db_xref="PDB:5F27"
/db_xref="PDB:5J1R"
/db_xref="PDB:5J1U"
/db_xref="PDB:5J1Y"
/db_xref="PDB:5J3L"
/db_xref="PDB:5MWO"
/db_xref="PDB:5MXK"
/db_xref="PDB:5MXV"
/db_xref="PDB:5MYL"
/db_xref="PDB:5MYM"
/db_xref="PDB:5MYN"
/db_xref="PDB:5MYR"
/db_xref="PDB:5MYS"
/db_xref="PDB:5MYT"
/db_xref="PDB:5MYW"
/db_xref="PDB:5NIM"
/db_xref="PDB:5NIO"
/db_xref="PDB:5NIZ"
/db_xref="PDB:5NJ0"
/db_xref="PDB:5NZ0"
/db_xref="PDB:5NZ1"
/db_xref="PDB:6HO0"
/db_xref="PDB:6HO4"
/db_xref="UniProtKB/Swiss-Prot:P9WMC1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46684.1"
/translation="MTTSAASQASLPRGRRTARPSGDDRELAILATAENLLEDRPLAD
ISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENM
WRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRG
AAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR"
gene complement(4328401..4329408)
/locus_tag="Rv3856c"
CDS complement(4328401..4329408)
/codon_start=1
/transl_table=11
/locus_tag="Rv3856c"
/product="Conserved hypothetical protein"
/note="Rv3856c, (MTCY01A6.12), len: 335 aa. Conserved
hypothetical protein, highly similar to various proteins
from diverse organisms e.g. Q9EWR3|3SCF60.21 conserved
hypothetical protein from Streptomyces coelicolor (372 aa)
FASTA scores: opt: 1286, E(): 2.4e-73, (64.0% identity in
336 aa overlap); P72464|ORF1 from Streptomyces lividans
(343 aa), FASTA scores: opt: 1275, E(): 1.1e-72, (60.1%
identity in 336 aa overlap); Q9K899|BH3107 DNA-dependent
DNA polymerase beta chain from Bacillus halodurans (571
aa), FASTA scores: opt: 592, E(): 1.2e-29, (39.15%
identity in 240 aa overlap); etc. May be a DNA polymerase
beta (gene name: yshC) (see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv3856c"
/db_xref="EnsemblGenomes-Tr:CCP46685"
/db_xref="GOA:P96221"
/db_xref="InterPro:IPR003141"
/db_xref="InterPro:IPR004013"
/db_xref="InterPro:IPR010996"
/db_xref="InterPro:IPR016195"
/db_xref="InterPro:IPR017078"
/db_xref="InterPro:IPR027421"
/db_xref="UniProtKB/TrEMBL:P96221"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46685.1"
/translation="MDPVTALRQIAYYKDRNRHDPRRVMAYRNAADIIEGLDDAARQR
HGQANSWQSLAGIGPKTAKVIAQAWSGREPDLLAELRADAEDLGGGAIRAALRGDLHL
HSNWSDGSAPIEEMMATAAALGHQYCALTDHSPRLTIANGLSPDRLRKQLDVIDELRE
KFAPLRILTGIEVDILEDGSLDQEPEMLDRLDIVVASVHSKLSMDSAAMTRRMVRAVA
NGHTDVLGHCTGRLIAGNRGIRPESKFDAEAVFTACREHGTAVEINSRPERRDPPTRL
LHLARDIGCVFSIDTDAHAPGQLDFLGYGAQRALDAEVPADRIVNTWPADTLLAWTGS
H"
gene complement(4329417..4329614)
/locus_tag="Rv3857c"
CDS complement(4329417..4329614)
/codon_start=1
/transl_table=11
/locus_tag="Rv3857c"
/product="Possible membrane protein"
/note="Rv3857c, (MTCY01A6.11), len: 65 aa. Possible
membrane protein."
/db_xref="EnsemblGenomes-Gn:Rv3857c"
/db_xref="EnsemblGenomes-Tr:CCP46686"
/db_xref="GOA:P96220"
/db_xref="UniProtKB/TrEMBL:P96220"
/protein_id="CCP46686.1"
/translation="MNCALGFDTKPILLASYVTHGARRATANQFERPAKGAGVLMALL
ILGEMAGFAVVVTGVVFGQLV"
gene complement(4330039..4331505)
/gene="gltD"
/locus_tag="Rv3858c"
CDS complement(4330039..4331505)
/codon_start=1
/transl_table=11
/gene="gltD"
/locus_tag="Rv3858c"
/product="Probable NADH-dependent glutamate synthase
(small subunit) GltD (L-glutamate synthase) (L-glutamate
synthetase) (NADH-glutamate synthase) (glutamate synthase
(NADH)) (GLTS beta chain) (NADPH-GOGAT)"
/note="Rv3858c, (MTCY01A6.10), len: 488 aa. Probable
gltD,small subunit of NADH-dependent glutamate
synthase,equivalent to Q9CDD4|GLTD|ML0062 NADH-dependent
glutamate synthase small subunit from Mycobacterium leprae
(488 aa),FASTA scores: opt: 2997, E(): 1e-166, (87.7%
identity in 488 aa overlap). Also highly similar to many
e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487
aa),FASTA scores: opt: 2152, E(): 1.2e-117, (63.85%
identity in 487 aa overlap); Q9KPJ3|VC2374 from Vibrio
cholerae (489 aa), FASTA scores: opt: 1699, E(): 2.5e-91,
(51.75% identity in 487 aa overlap); Q03460|GLSN_MEDSA
from Medicago sativa (Alfalfa) (2194 aa), FASTA scores:
opt: 1322, E(): 6.2e-69, (54.45% identity in 485 aa
overlap); P09832|GLTD_ECOLI from strain (471 aa) FASTA
scores: opt: 889, E() : 0, (37.4% identity in 473 aa
overlap); etc. Similar to other glutamate synthases.
Cofactor: FAD (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3858c"
/db_xref="EnsemblGenomes-Tr:CCP46687"
/db_xref="GOA:P9WN19"
/db_xref="InterPro:IPR006005"
/db_xref="InterPro:IPR009051"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR028261"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/Swiss-Prot:P9WN19"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46687.1"
/translation="MADPGGFLKYTHRKLPKRRPVPLRLRDWREVYEEFDNESLRQQA
TRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWRDAIERLHATNNFPDFTGRLCPAPC
EPACVLGINQDPVTIKQIELEIIDKAFDEGWVQPRPPRKLTGQTVAVVGSGPAGLAAA
QQLTRAGHTVTVFEREDRIGGLLRYGIPEFKMEKRHLDRRLDQMRSEGTEFRPGVNVG
VDISAEKLRADFDAVVLAGGATAWRELPIPGRELEGVHQAMEFLPWANRVQEGDDVLD
EDGQPPITAKGKKVVIIGGGDTGADCLGTVHRQGAIAVHQFEIMPRPPDARAESTPWP
TYPLMYRVSAAHEEGGERVFSVNTEAFVGTDGRVSALRAHEVTMLDGKFVKVEGSDFE
LEADLVLLAMGFVGPERAGLLTDLGVKFTERGNVARGDDFDTSVPGVFVAGDMGRGQS
LIVWAIAEGRAAAAAVDRYLMGSSALPAPVKPTAAPLQ"
gene complement(4331498..4336081)
/gene="gltB"
/locus_tag="Rv3859c"
CDS complement(4331498..4336081)
/codon_start=1
/transl_table=11
/gene="gltB"
/locus_tag="Rv3859c"
/product="Probable ferredoxin-dependent glutamate synthase
[NADPH] (large subunit) GltB (L-glutamate synthase)
(L-glutamate synthetase) (NADH-glutamate synthase)
(glutamate synthase (NADH))(NADPH-GOGAT)"
/note="Rv3859c, (MTCY01A6.09), len: 1527 aa. Probable
gltB,ferredoxin-dependent glutamate synthase large
subunit,equivalent to Q9CDD5|GLTB|ML0061 putative
ferredoxin-dependent glutamate synthase from Mycobacterium
leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25%
identity in 1527 aa overlap). Also highly similar to many
e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514
aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in
1544 aa overlap); Q9Z465|GLTB from Corynebacterium
glutamicum (Brevibacterium flavum) (1510 aa), FASTA
scores: opt: 5790, E(): 0, (63.25% identity in 1534 aa
overlap); P39812|GLTB_BACSU|GLTA from Bacillus subtilis
(1520 aa),FASTA scores: opt: 3445, E(): 2.8e-196, (52.25%
identity in 1531 aa overlap); etc. Similar to other
glutamate synthases."
/db_xref="EnsemblGenomes-Gn:Rv3859c"
/db_xref="EnsemblGenomes-Tr:CCP46688"
/db_xref="GOA:P96218"
/db_xref="InterPro:IPR002489"
/db_xref="InterPro:IPR002932"
/db_xref="InterPro:IPR006982"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR017932"
/db_xref="InterPro:IPR029055"
/db_xref="InterPro:IPR036485"
/db_xref="UniProtKB/Swiss-Prot:P96218"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46688.1"
/translation="MTPKRVGLYNPAFEHDSCGVAMVVDMHGRRSRDIVDKAITALLN
LEHRGAQGAEPRSGDGAGILIQVPDEFLREAVDFELPAPGSYATGIAFLPQSSKDAAA
ACAAVQKIAEAEGLQVLGWRSVPTDDSSLGALSRDAMPTFRQVFLAGASGMALERRCY
VVRKRAEHELGTKGPGQDGPGRETVYFPSLSGQTLVYKGMLTTPQLKAFYLDLQDERL
TSALGIVHSRFSTNTFPSWPLAHPFRRIAHNGEINTVTGNENWMRAREALIKTDIFGS
AADVEKLFPICTPGASDTARFDEVLELLHLGGRSLAHAVLMMIPEAWERHESMDPARR
AFYQYHASLMEPWDGPASMTFTDGTVVGAVLDRNGLRPSRIWVTDDGLVVMASEAGVL
DLHPSTVVRRMRLQPGRMFLVDTAQGRIVSDEEIKADLAAEHPYQEWLDNGLVPLDEL
PEGKDVRMPHHRIVMRQLAFGYTYEELNLLVAPMARLGAEPIGSMGTDTPVAVLSQRP
RMLYDYFHQLFAQVTNPPLDAIREEVVTSLQGTTGGERDLLNPDQNSCHQIVLPQPIL
RNHELAKLVSLDPNDKVNGRPHGLRSKVIRCLYRVSEGGAGLAAALEEVRGAAAAAIA
DGARIIILSDRESDEEMAPIPSLLAVAGVHHHLVRERTRTQVGLVVESGDAREVHHMA
ALVGFGAAAINPYLVFESIEDMLDRGVIEGIDRTAALNNYIKAAGKGVLKVMSKMGIS
TLASYTGAQLFQAVGISEQVLDEYFTGLTCPTGGITLDDIAADVAARHRLAYLDRPDE
RAHRELEVGGEYQWRREGEYHLFNPETVFKLQHSTRTGQYKIFKEYTRLVDDQSERMA
SLRGLLKFRTGVRPPVPLDEVEPASEIVKRFSTGAMSYGSISAEAHETLAIAMNRLGA
RSNCGEGGEDVKRFDRDPNGDWRRSAIKQVASARFGVTSHYLTNCTDLQIKMAQGAKP
GEGGQLPGHKVYPWVAEVRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANPSARV
HVKLVSENGVGTVAAGVSKAHADVVLISGHDGGTGATPLTSMKHAGAPWELGLAETQQ
TLLLNGLRDRIVVQVDGQLKTGRDVMIATLLGAEEFGFATAPLVVAGCIMMRVCHLDT
CPVGVATQNPLLRERFTGKPEFVENFFMFIAEEVREYLAQLGFRTVNEAVGQAGALDT
TLARAHWKAHKLDLAPVLHEPESAFMNQDLYCSSRQDHGLDKALDQQLIVMSREALDS
GKPVRFSTTIGNVNRTVGTMLGHELTKAYGGQGLPDGTIDITFDGSAGNSFGAFVPKG
ITLRVYGDANDYVGKGLSGGRIVVRPSDDAPQDYVAEDNIIGGNVILFGATSGEVYLR
GVVGERFAVRNSGAHAVVEGVGDHGCEYMTGGRVVILGRTGRNFAAGMSGGVAYVYDP
DGELPANLNSEMVELETLDEDDADWLHGTIQVHVDATDSAVGQRILSDWSGQQRHFVK
VMPRDYKRVLQAIALAERDGVDVDKAIMAAAHG"
gene 4336777..4337949
/locus_tag="Rv3860"
CDS 4336777..4337949
/codon_start=1
/transl_table=11
/locus_tag="Rv3860"
/product="Conserved protein"
/note="Rv3860, (MTCY01A6.08c), len: 390 aa. Conserved
protein, showing similarity with hypothetical proteins
from Mycobacterium leprae e.g. Q9CDD8|ML0048 (586 aa),
FASTA scores: opt: 484, E(): 5.5e-14, (29.95% identity in
407 aa overlap); O33082|MLCB628.11c (478 aa) FASTA scores:
opt: 484, E(): 4.8e-14, (29.95% identity in 407 aa
overlap); etc. Also some similarity with O86637|SC3C3.03c
hypothetical 112.1 KDA protein from Streptomyces
coelicolor(1083 aa), FASTA scores: opt: 483, E():
9.6e-14,(30.45% identity in 404 aa overlap). And some
similarity with other proteins from Mycobacterium
tuberculosis (strains H37Rv and CDC1551) e.g.
O05456|Rv3888c|MTCY15F10.24 hypothetical 37.7 KDA protein
(341 aa), FASTA scores: opt: 603, E(): 2.8e-19, (35.2%
identity in 284 aa overlap); O06396|Rv0530|MTCY25D10.09
hypothetical 43.0 KDA protein (405 aa), FASTA scores: opt:
538, E(): 2e-16, (31.0% identity in 371 aa overlap);
O69740|Rv3876|MTV027.11 (666 aa), FASTA scores: opt:
475,E(): 1.5e-13, (30.2% identity in 391 aa overlap); etc.
Contains PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3860"
/db_xref="EnsemblGenomes-Tr:CCP46689"
/db_xref="GOA:P96217"
/db_xref="InterPro:IPR002586"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P96217"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46689.1"
/translation="MYERDEFLRDRIRPHQPGTPRGYSPRPPSGDRCPAPPPGRHAAA
ATPPGPPRLPSAPLRPLPDPAWPRQPEAPPPSTWADPALAPIRSRTRPGERGWRRMVR
LVTFGLVGLGRSGMQRQEAQFEATIRTVLHGNHKVAVLGKGGVGKTSVAACVGSILAE
LRQQDRIVGIDADTAFGRLSSRIDPRAAGSFWELTTDTNLRSFTDITARLGRNSAGLY
VLAGQPASGPRRVLDPAIYREAALRLDHHFAISVIDCGSSMEAAVTQEVLRDVDALIV
VSSPWADGASAAANTIEWLSDYGLTGLLRRSIVVLNDSDGHADKRTKSLLAQEFIDHG
QPVVEVPFDPHLRPGGVIDMSHEMAPTTRLKILQVAATVTAYFASRPADAHGSPPR"
gene 4337946..4338272
/locus_tag="Rv3861"
CDS 4337946..4338272
/codon_start=1
/transl_table=11
/locus_tag="Rv3861"
/product="Hypothetical protein"
/note="Rv3861, (MTCY01A6.07c), len: 108 aa. Hypothetical
unknown protein. Overlaps in part next ORF Rv3862c|whiB6."
/db_xref="EnsemblGenomes-Gn:Rv3861"
/db_xref="EnsemblGenomes-Tr:CCP46690"
/db_xref="UniProtKB/TrEMBL:P96216"
/protein_id="CCP46690.1"
/translation="MTWLADPVGNSRIARAQACKTSISAPIVESWRAQRGAQCGQREK
SCRCSRAVHIQGISPPLFRRPLEPAVQAAVASCRLGRHPVVAHRVTVALGQGSQLAQR
ECPRPA"
gene complement(4338171..4338521)
/gene="whiB6"
/gene_synonym="whmF"
/locus_tag="Rv3862c"
CDS complement(4338171..4338521)
/codon_start=1
/transl_table=11
/gene="whiB6"
/gene_synonym="whmF"
/locus_tag="Rv3862c"
/product="Possible transcriptional regulatory protein
WhiB-like WhiB6"
/note="Rv3862c, (MTCY01A6.06), len: 116 aa. Possible whiB6
(alternate gene name: whmF), WhiB-like regulatory protein
(see citation below), similar to WhiB paralogue of
Streptomyces coelicolor, wblE gene product (85 aa). Shows
similarity with Q49765|WHIB7|ML0639|B1937_F2_68 putative
transcriptional regulator WHIB7 from Mycobacterium leprae
(89 aa) FASTA scores: opt: 112, E(): 0.49, (41.2% identity
in 51 aa overlap). Some similarity to Q9AD55|SCP1.95
putative regulatory protein from Streptomyces coelicolor
(102 aa) FASTA scores: opt: 129, E(): 0.038, (32.95%
identity in 85 aa overlap); AAK47632|MT3290.1 conserved
hypothetical protein from Mycobacterium tuberculosis
strain CDC1551 (96 aa), FASTA scores: opt: 126, E():
0.058,(33.35% identity in 84 aa overlap); Q9FC80|SC4B10.07
conserved hypothetical protein from Streptomyces
coelicolor (88 aa), FASTA scores: opt: 119, E(): 0.16,
(44.65% identity in 70 aa overlap); Q9K4K8|SC5F8.16c
regulatory protein from Streptomyces coelicolor (83 aa),
FASTA scores: opt: 114, E(): 0.34, (37.05% identity in 54
aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3862c"
/db_xref="EnsemblGenomes-Tr:CCP46691"
/db_xref="GOA:P9WF37"
/db_xref="InterPro:IPR003482"
/db_xref="InterPro:IPR034768"
/db_xref="UniProtKB/Swiss-Prot:P9WF37"
/protein_id="CCP46691.1"
/translation="MRYAFAAEATTCNAFWRNVDMTVTALYEVPLGVCTQDPDRWTTT
PDDEAKTLCRACPRRWLCARDAVESAGAEGLWAGVVIPESGRARAFALGQLRSLAERN
GYPVRDHRVSAQSA"
gene 4338849..4340027
/locus_tag="Rv3863"
CDS 4338849..4340027
/codon_start=1
/transl_table=11
/locus_tag="Rv3863"
/product="Unknown alanine rich protein"
/note="Rv3863, (MTCY01A6.05c), len: 392 aa. Unknown
ala-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv3863"
/db_xref="EnsemblGenomes-Tr:CCP46692"
/db_xref="GOA:P96214"
/db_xref="InterPro:IPR008984"
/db_xref="UniProtKB/TrEMBL:P96214"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46692.1"
/translation="MAGERKVCPPSRLVPANKGSTQMSKAGSTVGPAPLVACSGGTSD
VIEPRRGVAIIGHSCRVGTQIDDSRISQTHLRAVSDDGRWRIVGNIPRGMFVGGRRGS
SVTVSDKTLIRFGDPPGGKALTFEVVRPSDSAAQHGRVQPSADLSDDPAHNAAPVAPD
PGVVRAGAAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRERTRAKLEEVLQ
WPAGTIARIRRGEPTEPATNPDASPGLRPADGPASLIAQAVTAAVDGCSLAIAALPAT
EDPEFTERAAPILADLRQLEAIAVQATRISRITPELIKALGAVRRHHDELMRLGATAP
GATLAQRLYAARRRANLSTLETAQAAGVAEEMIVGAEAEEELPAEATEAIEALIRQIN
"
gene 4340270..4341478
/gene="espE"
/locus_tag="Rv3864"
CDS 4340270..4341478
/codon_start=1
/transl_table=11
/gene="espE"
/locus_tag="Rv3864"
/product="ESX-1 secretion-associated protein EspE"
/note="Rv3864, (MTCY01A6.04c), len: 402 aa. EspE, ESX-1
secretion-associated protein, similar to
Q49722|ML0405|B1620_C2_213|MLCL383.01 hypothetical 40.8
KDA protein from Mycobacterium leprae (394 aa) FASTA
scores: opt: 397, E(): 1.2e-12, (31.0% identity in 410 aa
overlap). Also similar to various proteins from several
organisms e.g. Q9VYF9|CG12723 hypothetical protein from
Drosophila melanogaster (Fruit fly) (450 aa), FASTA
scores: opt: 291,E(): 2.3e-07, (34.6% identity in 130 aa
overlap); Q98UE3 procollagen ALPHA1(III) (fragment) from
Xenopus laevis (African clawed frog) (117 aa) FASTA
scores: opt: 257, E(): 3.6e-06, (41.75% identity in 103 aa
overlap); P27393|CA24_ASCSU collagen alpha 2(IV) chain
precursor from Ascaris suum (Pig roundworm) (Ascaris
lumbricoides) (1763 aa), FASTA scores: opt: 273, E():
5.7e-06, (32.1% identity in 240 aa overlap); etc. Also
similar to O06267|Rv3616c|MTCY07H7B.06 (392 aa) FASTA
scores: opt: 389, E(): 3e-12, (31.6% identity in 399 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3864"
/db_xref="EnsemblGenomes-Tr:CCP46693"
/db_xref="GOA:P9WJD3"
/db_xref="UniProtKB/Swiss-Prot:P9WJD3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46693.1"
/translation="MASGSGLCKTTSNFIWGQLLLLGEGIPDPGDIFNTGSSLFKQIS
DKMGLAIPGTNWIGQAAEAYLNQNIAQQLRAQVMGDLDKLTGNMISNQAKYVSDTRDV
LRAMKKMIDGVYKVCKGLEKIPLLGHLWSWELAIPMSGIAMAVVGGALLYLTIMTLMN
ATNLRGILGRLIEMLTTLPKFPGLPGLPSLPDIIDGLWPPKLPDIPIPGLPDIPGLPD
FKWPPTPGSPLFPDLPSFPGFPGFPEFPAIPGFPALPGLPSIPNLFPGLPGLGDLLPG
VGDLGKLPTWTELAALPDFLGGFAGLPSLGFGNLLSFASLPTVGQVTATMGQLQQLVA
AGGGPSQLASMGSQQAQLISSQAQQGGQQHATLVSDKKEDEEGVAEAERAPIDAGTAA
SQRGQEGTVL"
gene 4341566..4341877
/gene="espF"
/locus_tag="Rv3865"
CDS 4341566..4341877
/codon_start=1
/transl_table=11
/gene="espF"
/locus_tag="Rv3865"
/product="ESX-1 secretion-associated protein EspF"
/note="Rv3865, (MTCY01A6.03c), len: 103 aa. EspF, ESX-1
secretion-associated protein, showing some similarity to
O06268|Rv3615c|MTCY07H7B.07 hypothetical 10.8 KDA protein
from Mycobacterium tuberculosis (103 aa), FASTA scores:
opt: 198, E(): 7.5e-07, (36.25% identity in 102 aa
overlap); Q49723|ML0406|B1620_C2_214|MLCL383.02
hypothetical 11.1 KDA protein from Mycobacterium leprae
(106 aa), FASTA scores: opt: 154, E(): 0.00071, (31.05%
identity in 103 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3865"
/db_xref="EnsemblGenomes-Tr:CCP46694"
/db_xref="GOA:P9WJD1"
/db_xref="InterPro:IPR022536"
/db_xref="UniProtKB/Swiss-Prot:P9WJD1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46694.1"
/translation="MTGFLGVVPSFLKVLAGMHNEIVGDIKRATDTVAGISGRVQLTH
GSFTSKFNDTLQEFETTRSSTGTGLQGVTSGLANNLLAAAGAYLKADDGLAGVIDKIF
G"
gene 4341880..4342731
/gene="espG1"
/gene_synonym="snm5"
/locus_tag="Rv3866"
CDS 4341880..4342731
/codon_start=1
/transl_table=11
/gene="espG1"
/gene_synonym="snm5"
/locus_tag="Rv3866"
/product="ESX-1 secretion-associated protein EspG1"
/note="Rv3866, (MTCY01A6.01c, MTV027.01), len: 283 aa.
espG1, ESX-1 secretion-associated protein. N-terminal end
highly similar to O33091|MLCB628.20c hypothetical 13.1 KDA
protein from Mycobacterium leprae (122 aa), FASTA scores:
opt: 260, E(): 2.1e-09, (43.6% identity in 117 aa
overlap); and C-terminal end highly similar to
O33090|MLCB628.19c hypothetical 36.7 KDA protein from
Mycobacterium leprae (338 aa), FASTA scores: opt: 540,
E(): 1.4e-26, (54.5% identity in 156 aa overlap). Also
similar to Q9CD34|ML2530 possible DNA-binding protein from
Mycobacterium leprae (289 aa), FASTA scores: opt: 146,
E(): 0.058, (28.25% identity in 269 aa overlap) and
O53694|Rv0289|MTV035.17 hypothetical 31.6 KDA protein from
Mycobacterium tuberculosis (295 aa),FASTA scores: opt:
133, E(): 0.39, (28.15% identity in 277 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3866"
/db_xref="EnsemblGenomes-Tr:CCP46695"
/db_xref="GOA:P96210"
/db_xref="InterPro:IPR025734"
/db_xref="UniProtKB/Swiss-Prot:P96210"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46695.1"
/translation="MTGPSAAGRAGTADNVVGVEVTIDGMLVIADRLHLVDFPVTLGI
RPNIPQEDLRDIVWEQVQRDLTAQGVLDLHGEPQPTVAEMVETLGRPDRTLEGRWWRR
DIGGVMVRFVVCRRGDRHVIAARDGDMLVLQLVAPQVGLAGMVTAVLGPAEPANVEPL
TGVATELAECTTASQLTQYGIAPASARVYAEIVGNPTGWVEIVASQRHPGGTTTQTDA
AAGVLDSKLGRLVSLPRRVGGDLYGSFLPGTQQNLERALDGLLELLPAGAWLDHTSDH
AQASSRG"
gene 4342770..4343321
/gene="espH"
/locus_tag="Rv3867"
CDS 4342770..4343321
/codon_start=1
/transl_table=11
/gene="espH"
/locus_tag="Rv3867"
/product="ESX-1 secretion-associated protein EspH"
/note="Rv3867, (MTV027.02), len: 183 aa. EspH, ESX-1
secretion-associated protein, highly similar to the
hypothetical proteins from Mycobacterium leprae:
Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403, E():
1.8e-18, (48.2% identity in 166 aa overlap);
Q49730|ML0407|B1620_C3_264|MLCL383.03 (216 aa), FASTA
scores: opt: 517, E(): 1.7e-25, (51.45% identity in 175 aa
overlap); and O33090|MLCB628.19c (338 aa), FASTA scores:
opt: 403, E(): 3.4e-18, (48.2% identity in 166 aa
overlap). Also highly similar to
O06269|Rv3614c|MTCY07H7B.08 hypothetical 19.8 KDA protein
from Mycobacterium tuberculosis (184 aa), FASTA scores:
opt: 559, E(): 3.4e-28, (54.35% identity in 173 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3867"
/db_xref="EnsemblGenomes-Tr:CCP46696"
/db_xref="GOA:O69732"
/db_xref="UniProtKB/Swiss-Prot:O69732"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46696.1"
/translation="MVDPPGNDDDHGDLDALDFSAAHTNEASPLDALDDYAPVQTDDA
EGDLDALHALTERDEEPELELFTVTNPQGSVSVSTLMDGRIQHVELTDKATSMSEAQL
ADEIFVIADLARQKARASQYTFMVENIGELTDEDAEGSALLREFVGMTLNLPTPEEAA
AAEAEVFATRYDVDYTSRYKADD"
gene 4343314..4345035
/gene="eccA1"
/locus_tag="Rv3868"
CDS 4343314..4345035
/codon_start=1
/transl_table=11
/gene="eccA1"
/locus_tag="Rv3868"
/product="ESX conserved component EccA1. ESX-1 type VII
secretion system protein."
/note="Rv3868, (MTV027.03), len: 573 aa. EccA1, esx
conserved component, ESX-1 type VII secretion system
protein. Member of the CbxX/CfqX family of hypothetical
proteins; C-terminal end is highly similar to many e.g.
P40118|CBXC_ALCEU|CBXXC|CFXXC CbxX protein (317 aa) FASTA
scores: opt: 572, E(): 3e-24, (42.7% identity in 294 aa
overlap); CAC48589 probable CBBX protein from Rhizobium
meliloti (Sinorhizobium meliloti) plasmid pSymB (311 aa)
FASTA scores: opt: 569, E(): 4.3e-24, (40.05% identity in
292 aa overlap); P95648|CBBX_RHOSH CBBX protein from
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
(309 aa), FASTA scores: opt: 559, E(): 1.5e-23, (41.4%
identity in 290 aa overlap); etc. Equivalent to
O33089|Y2G8_MYCLE|ML0055|MLCB628.18c hypothetical 62.3 KDA
protein from Mycobacterium leprae (573 aa), FASTA scores:
opt: 3330, E(): 3.9e-175, (89.2% identity in 573 aa
overlap); and similar to Q9CD28|Y282_MYCLE|ML2537
hypothetical 69.1 KDA protein from Mycobacterium leprae
(640 aa), FASTA scores: opt: 943, E(): 2.4e-44, (37.5%
identity in 571 aa overlap). Also similar to many proteins
from Mycobacterium tuberculosis (strains H37Rv and
CDC1551) e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10
hypothetical 68.1 KDA protein (631 aa), FASTA scores: opt:
936, E(): 5.8e-44, (39.05% identity in 568 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv3868"
/db_xref="EnsemblGenomes-Tr:CCP46697"
/db_xref="GOA:P9WPH9"
/db_xref="InterPro:IPR000641"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR023835"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041627"
/db_xref="PDB:4F3V"
/db_xref="UniProtKB/Swiss-Prot:P9WPH9"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46697.1"
/translation="MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGR
IRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAI
TMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAG
KWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRS
QGNESAAVALLEWLQTTHPEPKVAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDN
SGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGMKVAQPSKHMIFTG
PPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGG
VLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETN
EGLRSRFATRIEFDTYSPEELLEIANVIAAADDSALTAEAAENFLQAAKQLEQRMLRG
RRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEAIAAVH
AHLNMRE"
gene 4345039..4346481
/gene="eccB1"
/gene_synonym="snm6"
/locus_tag="Rv3869"
CDS 4345039..4346481
/codon_start=1
/transl_table=11
/gene="eccB1"
/gene_synonym="snm6"
/locus_tag="Rv3869"
/product="ESX conserved component EccB1. ESX-1 type VII
secretion system protein. Possible membrane protein."
/note="Rv3869, (MTV027.04), len: 480 aa. EccB1, esx
conserved component, ESX-1 type VII secretion system
protein, possible membrane protein (has hydrophobic
stretch near N-terminus), equivalent to
O33088|ML0054|MLCB628.17c putative membrane protein from
Mycobacterium leprae (481 aa), FASTA scores: opt: 2489,
E(): 8.3e-136, (75.75% identity in 478 aa overlap); and
similar to others e.g. Q9Z5I3|ML1544|MLCB596.27 conserved
membrane protein from Mycobacterium leprae (506 aa), FASTA
scores: opt: 739, E(): 3.9e-35, (33.65% identity in 490 aa
overlap). Also similar to hypothetical proteins from
Mycobacterium tuberculosis e.g.
O05449|Rv3895c|MTCY15F10.17 (495 aa), FASTA scores: opt:
795, E(): 2.3e-38, (35.8% identity in 486 aa overlap);
O53933|Rv1782|MTV049.04 (506 aa), FASTA scores: opt:
763,E(): 1.6e-36, (34.7% identity in 490 aa overlap);
O06317|Rv3450c|MTCY13E12.03c (470 aa) FASTA scores: opt:
717, E(): 6.7e-34, (32.55% identity in 479 aa overlap);
etc. A core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3869"
/db_xref="EnsemblGenomes-Tr:CCP46698"
/db_xref="GOA:P9WNR7"
/db_xref="InterPro:IPR007795"
/db_xref="InterPro:IPR042485"
/db_xref="PDB:3X3M"
/db_xref="PDB:3X3N"
/db_xref="PDB:4KK7"
/db_xref="PDB:5EBC"
/db_xref="PDB:5EBD"
/db_xref="UniProtKB/Swiss-Prot:P9WNR7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46698.1"
/translation="MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSI
ALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSAR
LVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTS
PVVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMG
IPVTARPTPISEGMFNALPDMGPWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGP
QYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLK
IVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGG
KFVALQSPDPRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPV
LSKDAALLEHDTLPADPSPRKVPAGASGAP"
gene 4346481..4348724
/gene="eccCa1"
/gene_synonym="snm1"
/locus_tag="Rv3870"
CDS 4346481..4348724
/codon_start=1
/transl_table=11
/gene="eccCa1"
/gene_synonym="snm1"
/locus_tag="Rv3870"
/product="ESX conserved component EccCa1. ESX-1 type VII
secretion system protein. Possible transmembrane protein."
/note="Rv3870, (MTV027.05), len: 747 aa. EccCa1, esx
conserved component, ESX-1 type VII secretion system
protein, possible transmembrane protein, equivalent to
O33087|ML0053|MLCB628.16c putative membrane protein from
Mycobacterium leprae (744 aa), FASTA scores: opt:
4333,E(): 0, (85.4% identity in 746 aa overlap); and
similar to N-terminal end of others e.g. Q9CD30|ML2535
hypothetical protein from Mycobacterium leprae (1329 aa),
FASTA scores: opt: 1003, E(): 1e-52, (33.65% identity in
725 aa overlap); O86653|SC3C3.20c ATP/GTP binding protein
from Streptomyces coelicolor (1321 aa), FASTA scores: opt:
1078, E(): 3e-57,(35.4% identity in 774 aa overlap);
P71068|YUKA YUKA protein from Bacillus subtilis (1207 aa)
FASTA scores: opt: 529, E(): 4.3e-24, (26.1% identity in
636 aa overlap); Q9KE81|BH0975 hypothetical protein from
Bacillus halodurans (1489 aa), FASTA scores: opt: 455,
E(): 1.5e-19, (27.1% identity in 734 aa overlap); etc.
Also similar to N-terminal end of hypothetical proteins
from Mycobacterium tuberculosis e.g.
O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 982,
E(): 1.9e-51, (33.8% identity in 719 aa overlap);
O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt:
761, E(): 4.1e-38, (38.2% identity in 746 aa overlap);
O53935|Rv1784|MTV049.06 (932 aa), FASTA scores: opt: 547,
E(): 2.8e-25, (36.25% identity in 276 aa overlap).
Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Note some similarity (with hypothetical proteins from
Mycobacterium tuberculosis and P71068|YUKA) continues in
downstream ORF MTV027.06."
/db_xref="EnsemblGenomes-Gn:Rv3870"
/db_xref="EnsemblGenomes-Tr:CCP46699"
/db_xref="GOA:P9WNB3"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR023836"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNB3"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46699.1"
/translation="MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPY
VMGGAMLGMIAIMVAGGTRQLSPYMLMMPLMMIVMMVGGLAGSTGGGGKKVPEINADR
KEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATR
IGIGDQPAVDRLLKPAVGGELAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQ
LRTFPTIAIGGDLAGAAGLMTAMICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPH
VQHQTETDAAGSTRLIFTRQEGLSDLAARGPHAPDSLPGGPYVVVVDLTGGKAGFPPD
GRAGVTVITLGNHRGSAYRIRVHEDGTADDRLPNQSFRQVTSVTDRMSPQQASRIARK
LAGWSITGTILDKTSRVQKKVATDWHQLVGAQSVEEITPSRWRMYTDTDRDRLKIPFG
HELKTGNVMYLDIKEGAEFGAGPHGMLIGTTGSGKSEFLRTLILSLVAMTHPDQVNLL
LTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQSILRQAGMKV
GAAGALSGVAEYEKYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRS
LRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNKESG
VGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGGPGQQTTRQAARIHRFTAAPV
LEEAPTP"
repeat_region 4348721..4348773
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
repeat_region 4348774..4348826
/note="53 bp Mycobacterial Interspersed Repetitive
Unit,Class II"
gene 4348827..4350602
/gene="eccCb1"
/gene_synonym="snm2"
/locus_tag="Rv3871"
CDS 4348827..4350602
/codon_start=1
/transl_table=11
/gene="eccCb1"
/gene_synonym="snm2"
/locus_tag="Rv3871"
/product="ESX conserved component EccCb1. ESX-1 type VII
secretion system protein."
/note="Rv3871, (MTV027.06), len: 591 aa. EccCb1, esx
conserved component, ESX-1 type VII secretion system
protein, equivalent to Q9CDD7|ML0052 hypothetical protein
from Mycobacterium leprae (597 aa) FASTA scores: opt:
3341,E(): 9.8e-192, (80.85% identity in 596 aa overlap);
and O33086|MLCB628.15c hypothetical protein from
Mycobacterium leprae (597 aa), FASTA scores: opt: 3329,
E(): 5.1e-191,(80.55% identity in 596 aa overlap). And
similar to C-terminal end of others e.g.
Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane
protein from Mycobacterium leprae (1345 aa), FASTA scores:
opt: 601, E(): 5.6e-28,(32.3% identity in 613 aa overlap);
O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces
coelicolor (1321 aa), FASTA scores: opt: 977, E():
2.1e-50, (35.15% identity in 583 aa overlap);
Q9L0T6|SCD35.15c putative cell division-related protein
from Streptomyces coelicolor (1525 aa), FASTA scores: opt:
414, E(): 9e-17, (27.6% identity in 424 aa
overlap);P71068|YUKA YUKA protein from Bacillus subtilis
(1207 aa), FASTA scores: opt: 343, E(): 1.3e-12,(25.8%
identity in 395 aa overlap); etc. And similar to to
C-terminal end of hypothetical proteins from Mycobacterium
tuberculosis e.g. O06264|Rv3447c|MTCY77.19c (1236 aa)
FASTA scores: opt: 845, E(): 1.5e-42, (35.3% identity in
586 aa overlap); O53689|Rv0284|MTV035.12 (1330 aa) FASTA
scores: opt: 646, E(): 1.2e-30, (33.35% identity in 606 aa
overlap); O53935|Rv1784|MTV049.06 (932 aa) FASTA scores:
opt: 589, E(): 2.1e-27, (33.1% identity in 619 aa
overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site
motif A (P-loop). Note some similarity (with hypothetical
proteins from Mycobacterium tuberculosis and P71068|YUKA)
continues in upstream ORF MTV027.05."
/db_xref="EnsemblGenomes-Gn:Rv3871"
/db_xref="EnsemblGenomes-Tr:CCP46700"
/db_xref="GOA:P9WNB1"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR023837"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNB1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46700.1"
/translation="MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIA
RDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNIGIGGAPQTGKSTLLQTMVMSAA
ATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETT
FKEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQ
GLAFGVHVIISTPRWTELKSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAV
SMEKHHLMIGVPRFDGVHSADNLVEAITAGVTQIASQHTEQAPPVRVLPERIHLHELD
PNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARA
ICARNSPQQVRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRL
PPTDLTTAQLRSRSWWSGFDVVLLVDDWHMIVGAAGGMPPMAPLAPLLPAAADIGLHI
IVTCQMSQAYKATMDKFVGAAFGSGAPTMFLSGEKQEFPSSEFKVKRRPPGQAFLVSP
DGKEVIQAPYIEPPEEVFAAPPSAG"
gene 4350745..4351044
/gene="PE35"
/locus_tag="Rv3872"
CDS 4350745..4351044
/codon_start=1
/transl_table=11
/gene="PE35"
/locus_tag="Rv3872"
/product="PE family-related protein PE35"
/note="Rv3872, (MTV027.07), len: 99 aa. PE35, Some
similarity to Mycobacterium tuberculosis conserved PE
family proteins (see Brennan & Delogu 2002), e.g.
O69713|Rv3746c|MTV025.094c (111 aa), FASTA scores: opt:
306, E(): 5.5e-13, (50.5% identity in 99 aa overlap).
Equivalent to AAK48354 from Mycobacterium tuberculosis
strain CDC1551 (112 aa) but shorter 14 aa."
/db_xref="EnsemblGenomes-Gn:Rv3872"
/db_xref="EnsemblGenomes-Tr:CCP46701"
/db_xref="GOA:P9WIG7"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/Swiss-Prot:P9WIG7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46701.1"
/translation="MEKMSHDPIAADIGTQVSDNALHGVTAGSTALTSVTGLVPAGAD
EVSAQAATAFTSEGIQLLASNASAQDQLHRAGEAVQDVARTYSQIDDGAAGVFAE"
gene 4351075..4352181
/gene="PPE68"
/locus_tag="Rv3873"
CDS 4351075..4352181
/codon_start=1
/transl_table=11
/gene="PPE68"
/locus_tag="Rv3873"
/product="PPE family protein PPE68"
/note="Rv3873, (MTV027.08), len: 368 aa. PPE68, Member of
the Mycobacterium tuberculosis PPE family, highly similar
to many e.g. O33085|ML0051|MLCB628.14c from Mycobacterium
leprae (302 aa), FASTA scores: opt: 656, E():
2.8e-24,(46.2% identity in 288 aa overlap); and
O53691|Rv0286|MTV035.14 (513 aa), FASTA scores: opt:
566,E(): 7.8e-20, (35.25% identity in 363 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004). Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3873"
/db_xref="EnsemblGenomes-Tr:CCP46702"
/db_xref="GOA:P9WHW9"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHW9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46702.1"
/translation="MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVE
LTARLNSLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMAT
TPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAV
NTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGP
MQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAG
LLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGA
QSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW"
gene 4352274..4352576
/gene="esxB"
/gene_synonym="cfp10"
/gene_synonym="lhp"
/locus_tag="Rv3874"
CDS 4352274..4352576
/codon_start=1
/transl_table=11
/gene="esxB"
/gene_synonym="cfp10"
/gene_synonym="lhp"
/locus_tag="Rv3874"
/product="10 kDa culture filtrate antigen EsxB (LHP)
(CFP10)"
/note="Rv3874, (MT3988, MTV027.09), len: 100 aa. EsxB, 10
KDA culture filtrate antigen (see citations
below,especially first), highly similar to
O33084|CF10_MYCLE|ML0050|MLCB628.13c 10 KDA culture
filtrate antigen CFP10 homolog from Mycobacterium leprae
(99 aa), FASTA scores: opt: 237, E(): 2.4e-08, (39.4%
identity in 99 aa overlap). Also similar to
O05440|ES6D_MYCTU|Rv3905c|MT4024|MTCY15F10.06 putative
ESAT-6 like protein 13 from Mycobacterium tuberculosis
(103 aa) FASTA scores: opt: 126, E(): 0.18, (23.1%
identity in 91 aa overlap); and shows some similarity with
other proteins from Mycobacterium tuberculosis. Contains
probable coiled-coil from aa 49-93. Belongs to the ESAT6
family. Note that previously known as lhp (alternate gene
name: cfp10). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3874"
/db_xref="EnsemblGenomes-Tr:CCP46703"
/db_xref="GOA:P9WNK5"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:1WA8"
/db_xref="PDB:3FAV"
/db_xref="UniProtKB/Swiss-Prot:P9WNK5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46703.1"
/translation="MAEMKTDAATLAQEAGNFERISGDLKTQIDQVESTAGSLQGQWR
GAAGTAAQAAVVRFQEAANKQKQELDEISTNIRQAGVQYSRADEEQQQALSSQMGF"
gene 4352609..4352896
/gene="esxA"
/gene_synonym="esat-6"
/locus_tag="Rv3875"
CDS 4352609..4352896
/codon_start=1
/transl_table=11
/gene="esxA"
/gene_synonym="esat-6"
/locus_tag="Rv3875"
/product="6 kDa early secretory antigenic target EsxA
(ESAT-6)"
/note="Rv3875, (MT3989, MTV027.10), len: 95 aa. EsxA,
early secretory antigenic target (see citations below),
identical to Q57165|O84901|ESAT6 early secretory antigenic
target from Mycobacterium bovis (94 aa), FASTA scores:
opt: 596,E(): 4.6e-33, (100.0% identity in 94 aa overlap).
Also similar to Q50206|ESA6_MYCLE|ESAT6|ESX|L45|ML0049|MLC
B628.12c 6 KDA early secretory antigenic target homolog
(ESAT-6-like protein) (L-ESAT) from Mycobacterium leprae
(95 aa), FASTA scores: opt: 236, E(): 3.3e-09, (36.25%
identity in 91 aa overlap); and weak similarity with
others proteins ESAT-like from Mycobacterium leprae. Also
some similarity with
O53266|ES69_MYCTU|Rv3019c|MT3104|MTV012.33c putative
secreted ESAT-6 like protein 9 from Mycobacterium
tuberculosis (96 aa), FASTA scores: opt: 131, E():
0.03,(26.15% identity in 88 aa overlap); and other
ESAT-like protein. Contains probable coiled-coil from 56
to 92 aa. Belongs to the ESAT6 family. Note that
previously known as esat-6. A core mycobacterial gene;
conserved in mycobacterial strains (See Marmiesse et al.,
2004). Predicted possible vaccine candidate (See Zvi et
al.,2008). EspD|Rv3614c expression but not secretion is
required for EsxA|Rv3875 secretion (See Chen et
al.,2012)."
/db_xref="EnsemblGenomes-Gn:Rv3875"
/db_xref="EnsemblGenomes-Tr:CCP46704"
/db_xref="GOA:P9WNK7"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="PDB:1WA8"
/db_xref="PDB:3FAV"
/db_xref="UniProtKB/Swiss-Prot:P9WNK7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46704.1"
/translation="MTEQQWNFAGIEAAASAIQGNVTSIHSLLDEGKQSLTKLAAAWG
GSGSEAYQGVQQKWDATATELNNALQNLARTISEAGQAMASTEGNVTGMFA"
gene 4353010..4355010
/gene="espI"
/gene_synonym="snm3"
/locus_tag="Rv3876"
CDS 4353010..4355010
/codon_start=1
/transl_table=11
/gene="espI"
/gene_synonym="snm3"
/locus_tag="Rv3876"
/product="ESX-1 secretion-associated protein EspI.
Conserved proline and alanine rich protein."
/note="Rv3876, (MTV027.11), len: 666 aa. EspI, ESX-1
secretion-associated protein, conserved pro-, ala-rich
protein, similar to several proteins from Mycobacterium
leprae e.g. Q9CDD8|ML0048 hypothetical protein (586
aa),FASTA scores: opt: 1682, E(): 2.1e-45, (50.75%
identity in 672 aa overlap); O33082|MLCB628.11c
hypothetical 52.0 KDA protein (478 aa), FASTA scores: opt:
1588, E(): 1.5e-42,(53.5% identity in 542 aa overlap)
(also has a proline rich N-terminus); etc. Also similar to
other proteins from Mycobacterium tuberculosis, especially
in C-terminus, e.g. O06396|Rv0530|MTCY25D10.09 (405 aa),
FASTA scores: opt: 670, E(): 2.5e-14, (34.85% identity in
396 aa overlap) (also has Pro-rich N-terminus); etc. Note
that N-terminus is repetitive and highly Proline rich."
/db_xref="EnsemblGenomes-Gn:Rv3876"
/db_xref="EnsemblGenomes-Tr:CCP46705"
/db_xref="GOA:P9WJC5"
/db_xref="InterPro:IPR002586"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WJC5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46705.1"
/translation="MAADYDKLFRPHEGMEAPDDMAAQPFFDPSASFPPAPASANLPK
PNGQTPPPTSDDLSERFVSAPPPPPPPPPPPPPTPMPIAAGEPPSPEPAASKPPTPPM
PIAGPEPAPPKPPTPPMPIAGPEPAPPKPPTPPMPIAGPAPTPTESQLAPPRPPTPQT
PTGAPQQPESPAPHVPSHGPHQPRRTAPAPPWAKMPIGEPPPAPSRPSASPAEPPTRP
APQHSRRARRGHRYRTDTERNVGKVATGPSIQARLRAEEASGAQLAPGTEPSPAPLGQ
PRSYLAPPTRPAPTEPPPSPSPQRNSGRRAERRVHPDLAAQHAAAQPDSITAATTGGR
RRKRAAPDLDATQKSLRPAAKGPKVKKVKPQKPKATKPPKVVSQRGWRHWVHALTRIN
LGLSPDEKYELDLHARVRRNPRGSYQIAVVGLKGGAGKTTLTAALGSTLAQVRADRIL
ALDADPGAGNLADRVGRQSGATIADVLAEKELSHYNDIRAHTSVNAVNLEVLPAPEYS
SAQRALSDADWHFIADPASRFYNLVLADCGAGFFDPLTRGVLSTVSGVVVVASVSIDG
AQQASVALDWLRNNGYQDLASRACVVINHIMPGEPNVAVKDLVRHFEQQVQPGRVVVM
PWDRHIAAGTEISLDLLDPIYKRKVLELAAALSDDFERAGRR"
repeat_region 4353280..4353330
/gene="espI"
/gene_synonym="snm3"
/locus_tag="Rv3876"
/note="51 bp imperfect direct repeat
1,GAACCGGCCGCATCTAAACCACCCACACCCCCCATGCCCATCGCCGGACCC"
repeat_region 4353331..4353381
/gene="espI"
/gene_synonym="snm3"
/locus_tag="Rv3876"
/note="51 bp imperfect direct repeat
2,GAACCGGCCCCACCCAAACCACCCACACCCCCCATGCCCATCGCCGGACCC"
repeat_region 4353382..4353432
/gene="espI"
/gene_synonym="snm3"
/locus_tag="Rv3876"
/note="51 bp imperfect direct repeat
3,GAACCGGCCCCACCCAAACCACCCACACCTCCGATGCCCATCGCCGGACCT"
gene 4355007..4356542
/gene="eccD1"
/gene_synonym="snm4"
/locus_tag="Rv3877"
CDS 4355007..4356542
/codon_start=1
/transl_table=11
/gene="eccD1"
/gene_synonym="snm4"
/locus_tag="Rv3877"
/product="ESX conserved component EccD1. ESX-1 type VII
secretion system protein. Probable transmembrane protein."
/note="Rv3877, (MTV027.12), len: 511 aa. EccD1, esx
conserved component, ESX-1 type VII secretion system
protein, probable transmembrane protein, equivalent to
Q9CDD9|ML0047 putative membrane protein from Mycobacterium
leprae (512 aa), FASTA scores: opt: 2496, E():
2.8e-140,(74.0% identity in 512 aa overlap); and highly
similar, but longer 32 aa, to O33081|MLCB628.10c
hypothetical 51.4 KDA protein from Mycobacterium leprae
(480 aa), FASTA scores: opt: 2346, E(): 2e-131, (74.15%
identity in 480 aa overlap). Shows also similarity with
other membrane proteins from Mycobacterium leprae e.g.
Q9CBV2|ML1539 probable membrane protein (503 aa), FASTA
scores: opt: 318,E(): 2e-11, (22.7% identity in 520 aa
overlap). Also similar to various proteins from
Mycobacterium tuberculosis e.g. O53944|Rv1795|MTV049.17
putative membrane protein (503 aa), FASTA scores: opt:
391, E(): 9.4e-16, (24.45% identity in 523 aa overlap);
O86362|Rv0290|MTV035.18 hypothetical 47.9 KDA protein (472
aa), FASTA scores: opt: 332, E(): 2.8e-12, (28.1% identity
in 509 aa overlap); O05457|Rv3887c|MTCY15F10.25
hypothetical 53.2 KDA protein (509 aa), FASTA scores: opt:
167, E(): 0.017, (24.0% identity in 517 aa overlap); etc.
Equivalent to AAK48359 from Mycobacterium tuberculosis
strain CDC1551 (479 aa) but longer 32 aa. A core
mycobacterial gene; conserved in mycobacterial strains
(See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3877"
/db_xref="EnsemblGenomes-Tr:CCP46706"
/db_xref="GOA:P9WNQ7"
/db_xref="InterPro:IPR006707"
/db_xref="InterPro:IPR024962"
/db_xref="PDB:4KV2"
/db_xref="PDB:4KV3"
/db_xref="UniProtKB/Swiss-Prot:P9WNQ7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46706.1"
/translation="MSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPM
ETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDG
SLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMA
MRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAAL
AVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAF
GYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPE
ATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHF
FVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLL
SVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRN
IRF"
gene 4356693..4357535
/gene="espJ"
/gene_synonym="TB27.4"
/locus_tag="Rv3878"
CDS 4356693..4357535
/codon_start=1
/transl_table=11
/gene="espJ"
/gene_synonym="TB27.4"
/locus_tag="Rv3878"
/product="ESX-1 secretion-associated protein EspJ.
Conserved alanine rich protein."
/note="Rv3878, (MTV027.13), len: 280 aa. EspJ, ESX-1
secretion-associated protein, conserved ala-rich protein.
Predicted to be an outer membrane protein (See Song et
al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3878"
/db_xref="EnsemblGenomes-Tr:CCP46707"
/db_xref="GOA:P9WJC3"
/db_xref="UniProtKB/Swiss-Prot:P9WJC3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46707.1"
/translation="MAEPLAVDPTGLSAAAAKLAGLVFPQPPAPIAVSGTDSVVAAIN
ETMPSIESLVSDGLPGVKAALTRTASNMNAAADVYAKTDQSLGTSLSQYAFGSSGEGL
AGVASVGGQPSQATQLLSTPVSQVTTQLGETAAELAPRVVATVPQLVQLAPHAVQMSQ
NASPIAQTISQTAQQAAQSAQGGSGPMPAQLASAEKPATEQAEPVHEVTNDDQGDQGD
VQPAEVVAAARDEGAGASPGQQPGGGVPAQAMDTGAGARPAASPLAAPVDPSTPAPST
TTTL"
gene complement(4357593..4359782)
/gene="espK"
/locus_tag="Rv3879c"
CDS complement(4357593..4359782)
/codon_start=1
/transl_table=11
/gene="espK"
/locus_tag="Rv3879c"
/product="ESX-1 secretion-associated protein EspK. Alanine
and proline rich protein."
/note="Rv3879c, (MTV027.14c), len: 729 aa. EspK, ESX-1
secretion-associated protein, ala- and pro-rich protein
(N-terminal end is repetitive and highly Proline-rich).
There may be an unknown protein Orf14 encoded in the
opposite orientation, within rv3879c (See Ahmad et
al.,1999; Daugelat et al., 2003)."
/db_xref="EnsemblGenomes-Gn:Rv3879c"
/db_xref="EnsemblGenomes-Tr:CCP46708"
/db_xref="GOA:P9WJC1"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WJC1"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46708.1"
/translation="MSITRPTGSYARQMLDPGGWVEADEDTFYDRAQEYSQVLQRVTD
VLDTCRQQKGHVFEGGLWSGGAANAANGALGANINQLMTLQDYLATVITWHRHIAGLI
EQAKSDIGNNVDGAQREIDILENDPSLDADERHTAINSLVTATHGANVSLVAETAERV
LESKNWKPPKNALEDLLQQKSPPPPDVPTLVVPSPGTPGTPGTPITPGTPITPGTPIT
PIPGAPVTPITPTPGTPVTPVTPGKPVTPVTPVKPGTPGEPTPITPVTPPVAPATPAT
PATPVTPAPAPHPQPAPAPAPSPGPQPVTPATPGPSGPATPGTPGGEPAPHVKPAALA
EQPGVPGQHAGGGTQSGPAHADESAASVTPAAASGVPGARAAAAAPSGTAVGAGARSS
VGTAAASGAGSHAATGRAPVATSDKAAAPSTRAASARTAPPARPPSTDHIDKPDRSES
ADDGTPVSMIPVSAARAARDAATAAASARQRGRGDALRLARRIAAALNASDNNAGDYG
FFWITAVTTDGSIVVANSYGLAYIPDGMELPNKVYLASADHAIPVDEIARCATYPVLA
VQAWAAFHDMTLRAVIGTAEQLASSDPGVAKIVLEPDDIPESGKMTGRSRLEVVDPSA
AAQLADTTDQRLLDLLPPAPVDVNPPGDERHMLWFELMKPMTSTATGREAAHLRAFRA
YAAHSQEIALHQAHTATDAAVQRVAVADWLYWQYVTGLLDRALAAAC"
gene complement(4360199..4360546)
/gene="espL"
/locus_tag="Rv3880c"
CDS complement(4360199..4360546)
/codon_start=1
/transl_table=11
/gene="espL"
/locus_tag="Rv3880c"
/product="ESX-1 secretion-associated protein EspL"
/note="Rv3880c, (MTV027.15c), len: 115 aa. EspL, ESX-1
secretion-associated protein, equivalent to
O33080|ML0044|MLCB628.09 hypothetical 12.2 KDA protein
from Mycobacterium leprae (113 aa), FASTA scores: opt:
397, E(): 2e-19, (56.35% identity in 110 aa overlap). A
core mycobacterial gene; conserved in mycobacterial
strains (See Marmiesse et al., 2004)."
/db_xref="EnsemblGenomes-Gn:Rv3880c"
/db_xref="EnsemblGenomes-Tr:CCP46709"
/db_xref="GOA:P9WJB9"
/db_xref="InterPro:IPR004401"
/db_xref="InterPro:IPR036894"
/db_xref="UniProtKB/Swiss-Prot:P9WJB9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46709.1"
/translation="MSMDELDPHVARALTLAARFQSALDGTLNQMNNGSFRATDEAET
VEVTINGHQWLTGLRIEDGLLKKLGAEAVAQRVNEALHNAQAAASAYNDAAGEQLTAA
LSAMSRAMNEGMA"
gene complement(4360543..4361925)
/gene="espB"
/locus_tag="Rv3881c"
CDS complement(4360543..4361925)
/codon_start=1
/transl_table=11
/gene="espB"
/locus_tag="Rv3881c"
/product="Secreted ESX-1 substrate protein B, EspB.
Conserved alanine and glycine rich protein"
/note="Rv3881c, (MTV027.16c), len: 460 aa. EspB, ESX-1
substrate protein B (See McLaughlin et al., 2007).
Conserved ala-, gly-rich protein. C-terminal end highly
similar to O06126 hypothetical 9.5 KDA protein (fragment)
from Mycobacterium tuberculosis strain NTI 64719 (90 aa)
FASTA scores: opt: 333, E(): 6.3e-07, (69.75% identity in
86 aa overlap) but sequence difference causes frameshift
in NTI 64719. Also similar to part of small Mycobacterium
leprae ORF O33078|MLCB628.06 (EMBL:Y14967) (101 aa), FASTA
scores: opt: 194, E(): 0.04, (59.3% identity in 54 aa
overlap), suggesting this is represented by a pseudogene
in Mycobacterium leprae."
/db_xref="EnsemblGenomes-Gn:Rv3881c"
/db_xref="EnsemblGenomes-Tr:CCP46710"
/db_xref="GOA:P9WJD9"
/db_xref="InterPro:IPR041275"
/db_xref="PDB:3J83"
/db_xref="PDB:4XWP"
/db_xref="PDB:4XXN"
/db_xref="PDB:4XXX"
/db_xref="PDB:4XY3"
/db_xref="UniProtKB/Swiss-Prot:P9WJD9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46710.1"
/translation="MTQSQTVTVDQQEILNRANEVEAPMADPPTDVPITPCELTAAKN
AAQQLVLSADNMREYLAAGAKERQRLATSLRNAAKAYGEVDEEAATALDNDGEGTVQA
ESAGAVGGDSSAELTDTPRVATAGEPNFMDLKEAARKLETGDQGASLAHFADGWNTFN
LTLQGDVKRFRGFDNWEGDAATACEASLDQQRQWILHMAKLSAAMAKQAQYVAQLHVW
ARREHPTYEDIVGLERLYAENPSARDQILPVYAEYQQRSEKVLTEYNNKAALEPVNPP
KPPPAIKIDPPPPPQEQGLIPGFLMPPSDGSGVTPGTGMPAAPMVPPTGSPGGGLPAD
TAAQLTSAGREAAALSGDVAVKAASLGGGGGGGVPSAPLGSAIGGAESVRPAGAGDIA
GLGQGRAGGGAALGGGGMGMPMGAAHQGQGGAKSKGSQQEDEALYTEDRAWTEAVIGN
RRRQDSKESK"
gene complement(4362032..4363420)
/gene="eccE1"
/gene_synonym="snm7"
/locus_tag="Rv3882c"
CDS complement(4362032..4363420)
/codon_start=1
/transl_table=11
/gene="eccE1"
/gene_synonym="snm7"
/locus_tag="Rv3882c"
/product="ESX conserved component EccE1. ESX-1 type VII
secretion system protein. Possible membrane protein."
/note="Rv3882c, (MTV027.17c, MTCY15F10.30), len: 462 aa.
eccE1, esx conserved component, ESX-1 type VII secretion
system protein, possible membrane protein, equivalent to
O33077|ML0042|MLCB628.05 putative membrane protein from
Mycobacterium leprae (467 aa), FASTA scores: opt:
2346,E(): 1.1e-140, (72.1% identity in 462 aa overlap).
Also similar to O05459|Rv3885c|MTCY15F10.27 possible
membrane protein from Mycobacterium tuberculosis (537 aa)
FASTA scores: opt: 283, E(): 2.5e-10, (26.8% identity in
414 aa overlap); and C-terminal end shows similarity with
AAK48368|MT4000 hypothetical 45.6 KDA protein from
Mycobacterium tuberculosis strain CDC1551 (422 aa) FASTA
scores: opt: 215, E(): 4.1e-06, (26.85% identity in 320 aa
overlap). A core mycobacterial gene; conserved in
mycobacterial strains (See Marmiesse et al., 2004).
Rv3614c and Rv3882c interact, by yeast two-hybrid analysis
(See MacGurn et al., 2005)."
/db_xref="EnsemblGenomes-Gn:Rv3882c"
/db_xref="EnsemblGenomes-Tr:CCP46711"
/db_xref="GOA:P9WJE9"
/db_xref="InterPro:IPR021368"
/db_xref="UniProtKB/Swiss-Prot:P9WJE9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46711.1"
/translation="MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLG
VIVATVTFYGRRITGWVAAVYAWLRRRRRPPDSSSEPVVGATVKPGDHVAVRWQGEFL
VAVIELIPRPFTPTVIVDGQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTA
APDVVSLYQQVIGTDPAPANRRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATR
IADRLASHGVDAVCGRSFDDYDHATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWS
ARADHTITRVRVAPGMAPQSTVLLTTADKPKTPRGFARLFGGQRPALQGQHLVANRHC
QLPIGSAGVLVGETVNRCPVYMPFDDVDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQ
FEEFARLIGAHIGQEVKVAWPNATTYLGPHPGIDRVILRHNVIGTPRHRQLPIRRVSP
PEESRYQMALPK"
gene complement(4363417..4364757)
/gene="mycP1"
/gene_synonym="snm8"
/locus_tag="Rv3883c"
CDS complement(4363417..4364757)
/codon_start=1
/transl_table=11
/gene="mycP1"
/gene_synonym="snm8"
/locus_tag="Rv3883c"
/product="Membrane-anchored mycosin MycP1 (serine
protease) (subtilisin-like protease) (subtilase-like)
(mycosin-1)"
/note="Rv3883c, (MTCY15F10.29), len: 446 aa.
MycP1,membrane-anchored serine protease (mycosin) (see
citations below), equivalent to O33076|ML0041|MLCB628.04
probable secreted protease from Mycobacterium leprae (446
aa), FASTA scores: opt: 2448, E(): 1.5e-124, (79.15%
identity in 446 aa overlap); and highly similar, but in
part, to several putative proteases from Mycobacterium
leprae; Q9CBV3|ML1538 (567 aa) FASTA scores: opt: 902,
E(): 3e-41, (37.25% identity in 556 aa overlap); and
Q9CD36|ML2528 (475 aa),FASTA scores: opt: 873, E():
9.4e-40, (42.7% identity in 459 aa overlap). Shows also
similarity with several proteases from other organisms
e.g. Q9PCD0|XF1851 serine protease from Xylella fastidiosa
(1000 aa), FASTA scores: opt: 281, E(): 1.3e-07, (27.95%
identity in 422 aa overlap); P42780|BPRX_BACNO
extracellular subtilisin-like protease precursor from
Bacteroides nodosus (Dichelobacter nodosus) (595 aa),
FASTA scores: opt: 270, E(): 3.2e-07,(28.9% identity in
384 aa overlap); Q46541|APRV5 acidic protease V5 from
Bacteroides nodosus (Dichelobacter nodosus) (595 aa),
FASTA scores: opt: 264, E(): 6.8e-07,(28.65% identity in
384 aa overlap); etc. Also highly similar to various
proteins from Mycobacterium tuberculosis e.g.
O53695|Rv0291|MTV035.19 probable membrane-anchored mycosin
MYCP3 (461 aa), FASTA scores: opt: 1168, E(): 1.2e-55,
(44.6% identity in 453 aa overlap);
O53945|Rv1796|MTV049.18 probable membrane-anchored mycosin
MYCP5 (585 aa), FASTA scores: opt: 928, E():
1.2e-42,(37.85% identity in 555 aa overlap) (note gap from
aa 155-264); and downstream ORF
O05458|Rv3886c|MTCY15F10.26 probable membrane-anchored
mycosin MYCP2 (550 aa), FASTA scores: opt: 910, E():
1.1e-41, (40.15% identity in 533 aa overlap) (note partial
gap from aa 146-234); etc. Equivalent to AAK48366 from
Mycobacterium tuberculosis strain CDC1551 (411 aa) but
longer 35 aa. Has signal sequence with possible signal
peptidase I cleavage site in residues 19-21 (ASA) and
hydrophobic stretch at C-terminus,followed by short
positively charged segment, that seems to act as a
membrane anchor. Activated by Ca2+ (see Dave et al.,
2002). Contains three serine protease, subtilase family
active site motifs: a aspartic acid active site motif
(PS00136); a histidine active site motif (PS00137); and a
serine active site motif (PS00138). Belongs to peptidase
family S8 (also known as the subtilase family),pyrolysin
subfamily. Conserved in M. tuberculosis, M. leprae, M.
bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3883c"
/db_xref="EnsemblGenomes-Tr:CCP46712"
/db_xref="GOA:O05461"
/db_xref="InterPro:IPR000209"
/db_xref="InterPro:IPR015500"
/db_xref="InterPro:IPR023834"
/db_xref="InterPro:IPR036852"
/db_xref="UniProtKB/Swiss-Prot:O05461"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46712.1"
/translation="MHRIFLITVALALLTASPASAITPPPIDPGALPPDVTGPDQPTE
QRVLCASPTTLPGSGFHDPPWSNTYLGVADAHKFATGAGVTVAVIDTGVDASPRVPAE
PGGDFVDQAGNGLSDCDAHGTLTASIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEP
VGSQANPNDPNATPAAGSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGA
SIDYAVNVKGVVVVVAAGNTGGDCVQNPAPDPSTPGDPRGWNNVQTVVTPAWYAPLVL
SVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDTGEPVNALQGREGPVPIAGTSFA
AAYVSGLAALLRQRFPDLTPAQIIHRITATARHPGGGVDDLVGAGVIDAVAALTWDIP
PGPASAPYNVRRLPPPVVEPGPDRRPITAVALVAVGLTLALGLGALARRALSRR"
gene complement(4364979..4366838)
/gene="eccA2"
/locus_tag="Rv3884c"
CDS complement(4364979..4366838)
/codon_start=1
/transl_table=11
/gene="eccA2"
/locus_tag="Rv3884c"
/product="ESX conserved component EccA2. ESX-2 type VII
secretion system protein. Probable CbxX/CfqX family
protein."
/note="Rv3884c, (MTCY15F10.28), len: 619 aa. eccA2, esx
conserved component, ESX-2 type VII secretion system
protein. Probable CbxX/CfqX protein family, similar to
hypothetical proteins from Mycobacterium leprae e.g.
Q9CD28|Y282_MYCLE|ML2537 (640 aa), FASTA scores: opt:
725,E(): 2.9e-34, (28.95% identity in 587 aa overlap);
O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (belongs to the
CbxX/CfqX family) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA
scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa
overlap). Also similar to proteins belonging to the
CbxX/CfqX family e.g. Q9RKZ2|SC6D7.05c putative CbxX/CfqX
family protein from Streptomyces coelicolor (618 aa) FASTA
scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa
overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ stage V
sporulation protein K from Bacillus subtilis (322 aa)
FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in
280 aa overlap) (similarity only at C-terminus);
Q9KAC6|BH2363 stage V sporulation protein K from Bacillus
halodurans (315 aa),FASTA scores: opt: 462, E(): 2.2e-19,
(36.05% identity in 244 aa overlap) (similarity only at
C-terminus); etc. And similar to hypothetical proteins
from Mycobacterium tuberculosis belonging to the CbxX/CfqX
family e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10
hypothetical 68.1 KDA protein (631 aa), FASTA scores: opt:
743, E(): 2.6e-35,(29.9% identity in 612 aa overlap);
O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 hypothetical
62.4 KDA protein (573 aa), FASTA scores: opt: 678, E():
1.3e-31,(31.25% identity in 589 aa overlap);
O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA
scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Seems to belong to the CbxX/CfqX family."
/db_xref="EnsemblGenomes-Gn:Rv3884c"
/db_xref="EnsemblGenomes-Tr:CCP46713"
/db_xref="GOA:P9WPH7"
/db_xref="InterPro:IPR000641"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR023835"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041627"
/db_xref="UniProtKB/Swiss-Prot:P9WPH7"
/inference="protein motif:PROSITE:PS00017"
/protein_id="CCP46713.1"
/translation="MSRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEAD
PSMADAWLGRIACGDRDLASLKQLNAHSEWLHRETTRIGRTLAAEVQLGPSIGITVTD
ASQVGLALSSALTIAGEYAKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVL
STAAEDLPPQAIVMPAVTASICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFG
ADVLTAAIGPADIPLLVADLAYVRGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEAL
ADPNLRLIVTDERTIASRSDRWDASTAKSRDQLDDDNAAQRRGELLAEGRELLAKQVG
LAAVKQAVSALEDQLEVRMMRLEHGLPVEGQTNHMLLVGPPGTGKTTTAEALGKIYAG
MGIVRHPEIREVRRSDFCGHYIGESGPKTNELIEKSLGRIIFMDEFYSLIERHQDGTP
DMIGMEAVNQLLVQLETHRFDFCFIGAGYEDQVDEFLTVNPGLAGRFNRKLRFESYSP
VEIVEIGHRYATPRASQLDDAAREVFLDAVTTIRNYTTPSGQHGIDAMQNGRFARNVI
ERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDIDAAIRSVCSDNRDMAAIVW"
gene complement(4366908..4368521)
/gene="eccE2"
/locus_tag="Rv3885c"
CDS complement(4366908..4368521)
/codon_start=1
/transl_table=11
/gene="eccE2"
/locus_tag="Rv3885c"
/product="ESX conserved component EccE2. ESX-2 type VII
secretion system protein. Possible membrane protein."
/note="Rv3885c, (MTCY15F10.27), len: 537 aa. eccE2, esx
conserved component, ESX-2 type VII secretion system
protein. possible membrane protein (has hydrophobic
stretch near N-terminus), showing some similarity with
O05462|Rv3882c|MTV027.17c|MTCY15F10.30 possible membrane
protein from Mycobacterium tuberculosis (462 aa) FASTA
scores: opt: 283, E(): 8.3e-10, (26.55% identity in 414 aa
overlap); and O33077|ML0042|MLCB628.05 putative membrane
protein from Mycobacterium leprae (467 aa), FASTA scores:
opt: 260, E(): 2.1e-08, (28.0% identity in 382 aa
overlap). Equivalent to AAK48368 from Mycobacterium
tuberculosis strain CDC1551 (422 aa) but longer 115 aa."
/db_xref="EnsemblGenomes-Gn:Rv3885c"
/db_xref="EnsemblGenomes-Tr:CCP46714"
/db_xref="GOA:P9WJE7"
/db_xref="InterPro:IPR021368"
/db_xref="UniProtKB/Swiss-Prot:P9WJE7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46714.1"
/translation="MTSKLTGFSPRSARRVAGVWTVFVLASAGWALGGQLGAVMAVVV
GVALVFVQWWGQPAWSWAVLGLRGRRPVKWNDPITLANNRSGGGVRVQDGVAVVAVQL
LGRAHRATTVTGSVTVESDNVIDVVELAPLLRHPLDLELDSISVVTFGSRTGTVGDYP
RVYDAEIGTPPYAGRRETWLIMRLPVIGNTQALRWRTSVGAAAISVAQRVASSLRCQG
LRAKLATATDLAELDRRLGSDAVAGSAQRWKAIRGEAGWMTTYAYPAEAISSRVLSQA
WTLRADEVIQNVTVYPDATCTATITVRTPTPAPTPPSVILRRLNGEQAAAAAANMCGP
RPHLRGQRRCPLPAQLVTEIGPSGVLIGKLSNGDRLMIPVTDAGELSRVFVAADDTIA
KRIVIRVVGAGERVCVHTRDQERWASVRMPQLSIVGTPRPAPRTTVGVVEYVRRRKNG
DDGKSEGSGVDVAISPTPRPASVITIARPGTSLSESDRHGFEVTIEQIDRATVKVGAA
GQNWLVEMEMFRAENRYVSLEPVTMSIGR"
gene complement(4368518..4370170)
/gene="mycP2"
/locus_tag="Rv3886c"
CDS complement(4368518..4370170)
/codon_start=1
/transl_table=11
/gene="mycP2"
/locus_tag="Rv3886c"
/product="Probable alanine and proline rich
membrane-anchored mycosin MycP2 (serine protease)
(subtilisin-like protease) (subtilase-like) (mycosin-2)"
/note="Rv3886c, (MTCY15F10.26), len: 550 aa. Probable
mycP2, ala-, pro-rich membrane-anchored serine protease
(mycosin) (see citation below), highly similar to
Q9CBV3|ML1538 possible protease from Mycobacterium leprae
(567 aa), FASTA scores: opt: 1034, E(): 3.9e-32, (43.5%
identity in 575 aa overlap); and highly similar, but with
gaps, to several putative proteases from Mycobacterium
leprae; O33076|ML0041|MLCB628.04 (446 aa), FASTA scores:
opt: 860, E(): 1.1e-25, (38.65% identity in 538 aa
overlap); Q9CD36|ML2528 (475 aa) (475 aa), FASTA scores:
opt: 413, E(): 7.1e-09, (37.7% identity in 562 aa
overlap). Also similarity with Q99405|PRTM_BACSP
M-protease from Bacillus sp. strain KSM-K16 (269 aa),
FASTA scores: E(): 7.6e-06, (27.1% identity in 277 aa
overlap). And highly similar, but also with gaps, to other
mycosins from Mycobacterium tuberculosis e.g.
O53945|Rv1796|MTV049.18 (585 aa), FASTA scores: opt: 1173,
E(): 2.4e-37, (47.9% identity in 578 aa overlap); the
upstream ORF O05461|Rv3883c|MTCY15F10.29 (446 aa) FASTA
scores: opt: 910, E(): 1.5e-27, (40.15% identity in 533 aa
overlap); O06316|Rv3449|MTCY13E12.02 (455 aa) FASTA
scores: opt: 477,E(): 2.7e-11, (38.75% identity in 550 aa
overlap); etc. Contains Pro rich protein with two serine
protease,subtilase family active site motifs: aspartic
acid active site motif (PS00136); and histidine active
site motif (PS00137). Belongs to peptidase family S8 (also
known as the subtilase family), pyrolysin subfamily.
Thought to be cleaved into smaller molecular weight
proteins, 36 and 29 KDA (see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv3886c"
/db_xref="EnsemblGenomes-Tr:CCP46715"
/db_xref="GOA:O05458"
/db_xref="InterPro:IPR000209"
/db_xref="InterPro:IPR015500"
/db_xref="InterPro:IPR023827"
/db_xref="InterPro:IPR023834"
/db_xref="InterPro:IPR036852"
/db_xref="UniProtKB/Swiss-Prot:O05458"
/inference="protein motif:PROSITE:PS00137"
/inference="protein motif:PROSITE:PS00136"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46715.1"
/translation="MASPLNRPGLRAAAASAALTLVALSANVPAAQAIPPPSVDPAMV
PADARPGPDQPMRRSNSCSTPITVRNPDVAQLAPGFNLVNISKAWQYSTGNGVPVAVI
DTGVSPNPRLPVVPGGDYIMGEDGLSDCDAHGTVVSSIIAAAPLGILPMPRAMPATAA
FPPPAGPPPVTAAPAPPVEVPPPMPPPPPVTITQTVAPPPPPPEDAGAMAPSNGPPDP
QTEDEPAVPPPPPGAPDGVVGVAPHATIISIRQSSRAFEPVNPSSAGPNSDEKVKAGT
LDSVARAVVHAANMGAKVINISVTACLPAAAPGDQRVLGAALWYAATVKDAVIVAAAG
NDGEAGCGNNPMYDPLDPSDPRDWHQVTVVSSPSWFSDYVLSVGAVDAYGAALDKSMS
GPWVGVAAPGTHIMGLSPQGGGPVNAYPPSRPGEKNMPFWGTSFSAAYVSGVAALVRA
KFPELTAYQVINRIVQSAHNPPAGVDNKLGYGLVDPVAALTFNIPSGDRMAPGAQSRV
ITPAAPPPPPDHRARNIAIGFVGAVATGVLAMAIGARLRRAR"
gene complement(4370155..4371684)
/gene="eccD2"
/locus_tag="Rv3887c"
CDS complement(4370155..4371684)
/codon_start=1
/transl_table=11
/gene="eccD2"
/locus_tag="Rv3887c"
/product="ESX conserved component EccD2. ESX-2 type VII
secretion system protein. Probable transmembrane protein."
/note="Rv3887c, (MTCY15F10.25), len: 509 aa. eccD2, esx
conserved component, ESX-2 type VII secretion system
protein, probable transmembrane protein (has hydrophilic
stretch from ~1-130 then very hydrophobic domain), similar
to other membrane proteins and with weak similarity to
known transporters, e.g. Q9CBV2|ML1539 probable membrane
protein from Mycobacterium leprae (503 aa), FASTA scores:
opt: 395, E(): 2.3e-16, (28.0% identity in 496 aa
overlap); Q9CD35|ML2529 conserved membrane protein from
Mycobacterium leprae (485 aa), FASTA scores: opt: 221,
E(): 6.6e-06,(24.6% identity in 423 aa overlap);
Q9ADP8|2SC10A7.11 putative integral membrane protein from
Streptomyces coelicolor (430 aa), FASTA scores: opt: 171,
E(): 0.0062,(26.55% identity in 358 aa overlap);
CAC44275|SCBAC17F8.03 putative drug efflux protein from
Streptomyces coelicolor (416 aa), FASTA scores: opt: 160,
E(): 0.028, (27.85% identity in 323 aa overlap); etc. Also
similar to others from Mycobacterium tuberculosis e.g.
O53944|Rv1795|MTV049.17 putative membrane protein (503
aa),FASTA scores: opt: 360, E(): 2.9e-14, (26.65% identity
in 514 aa overlap); etc. Equivalent to AAK48369 from
Mycobacterium tuberculosis strain CDC1551 (469 aa) but
longer 40 aa."
/db_xref="EnsemblGenomes-Gn:Rv3887c"
/db_xref="EnsemblGenomes-Tr:CCP46716"
/db_xref="GOA:P9WNQ5"
/db_xref="InterPro:IPR006707"
/db_xref="InterPro:IPR024962"
/db_xref="UniProtKB/Swiss-Prot:P9WNQ5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46716.1"
/translation="MTAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVEL
FDADLKRKGFDGVALPAGSYELHKINGVRLDINKSLDELGVQDGDTLVLVPRVAGESF
EPQYESLSTGLAAMGKWLGRDGGDRMFAPVTSLTAAHTAMAIIAMAVGVVLALTLRTR
TITDSPVPAAMAGGIGVLLVIGALVVWWGWRERRDLFSGFGWLAVVLLAVAAACAPPG
ALGAAHALIGLVVVVLGAITIGVATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSM
QVLAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARRAGMPVDTVAPVSE
ADADDEDNELTDITARGTAIAASARLVNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAW
LALLVAGLTVGLFITQGRGFAAKYQAVALVCGASAAVCAGVLKYALDTPKGVQTGLLW
PAIFVAAFAALGLAVALVVPATRFRPIIRLTVEWLEVLAMIALLPAAAALGGLFAWLR
H"
gene complement(4371681..4372706)
/locus_tag="Rv3888c"
CDS complement(4371681..4372706)
/codon_start=1
/transl_table=11
/locus_tag="Rv3888c"
/product="Probable conserved membrane protein"
/note="Rv3888c, (MTCY15F10.24), len: 341 aa. Probable
conserved membrane protein, showing similarity with
hypothetical proteins from Mycobacterium leprae:
O33082|MLCB628.11c (478 aa), FASTA scores: opt: 530, E():
7.7e-26, (32.45% identity in 336 aa overlap);
Q9CDD8|ML0048 (586 aa), FASTA scores: opt: 530, E():
9.1e-26, (32.45% identity in 336 aa overlap);
Q9CCI1|ML0798 (592 aa), FASTA scores: opt: 426, E():
3e-19, (27.5% identity in 342 aa overlap) (similarity only
at C-terminus). Also similar to proteins from
Mycobacterium tuberculosis e.g. P96217|Rv3860|MTCY01A6.08c
(390 aa), FASTA scores: opt: 603, E(): 1.7e-30, (35.2%
identity in 284 aa overlap); O06396|Rv0530|MTCY25D10.09
(405 aa), FASTA scores: opt: 573, E(): 1.3e-28, (32.0%
identity in 328 aa overlap); C-terminus of
O69740|Rv3876|MTV027.1 (666 aa), FASTA scores: opt: 509,
E(): 2.1e-24, (31.0% identity in 303 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3888c"
/db_xref="EnsemblGenomes-Tr:CCP46717"
/db_xref="GOA:O05456"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O05456"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46717.1"
/translation="MTNPWNDPNMLDDGAIGRGDPSVRHHFRDSVSDTMRITDLAAPR
KIPPGTGWRKFVYSVSFHKINPGESPRERHYRNLQGRIRRHIRRQYVITVVSGKGGVG
VTTMAACIGGVFRECRPENVIAIDAVPSFGTLADRIDESPPGDYAAIINDTDVQGYAD
IREHLGQNTVGLDVLAGNRTSDQPRPLVPAMFSAVLSRLRRTHTVIVIDTSPDLEHDV
MKAVLQSTDTLVFVSGITADRSRPVLRAVDYLRAQGYHELVSRSTVILNHTDSITDKD
ALAYLTERFTKVGAIVEAMPFDPHLAKGGIIDTVHELNKKSRLRLFEITAGLADKYVP
DAERAAQ"
gene complement(4372800..4373630)
/gene="espG2"
/locus_tag="Rv3889c"
CDS complement(4372800..4373630)
/codon_start=1
/transl_table=11
/gene="espG2"
/locus_tag="Rv3889c"
/product="ESX-2 secretion-associated protein EspG2"
/note="Rv3889c, (MTCY15F10.23), len: 276 aa. EspG2, ESX-2
secretion-associated protein."
/db_xref="EnsemblGenomes-Gn:Rv3889c"
/db_xref="EnsemblGenomes-Tr:CCP46718"
/db_xref="GOA:P9WJC9"
/db_xref="InterPro:IPR025734"
/db_xref="UniProtKB/Swiss-Prot:P9WJC9"
/protein_id="CCP46718.1"
/translation="MLTTTVDGLWVLQAVTGVEQTCPELGLRPLLPRLDTAERALRHP
VAAELMAVGALDQAGNADPMVREWLTVLLRRDLGLLVTIGVPGGEPTRAAICRFATWW
VVLERHGNLVRLYPAGTASDEAGAGELVVGQVERLCGVAEAAPLRPVTVDADELLHAV
RDAGTLRSYLLSQRLDVDQLQMVTMAADPTRSAHATLVALQAGVGPEKSARILVGDST
VAIVDTAAGRICVESVTSGQRRYQVLSPGSRSDIGGAVQRLIRRLPAGDEWYSYRRVV
"
gene complement(4373726..4374013)
/gene="esxC"
/gene_synonym="ES6_11"
/locus_tag="Rv3890c"
CDS complement(4373726..4374013)
/codon_start=1
/transl_table=11
/gene="esxC"
/gene_synonym="ES6_11"
/locus_tag="Rv3890c"
/product="ESAT-6 like protein EsxC (ESAT-6 like protein
11)"
/note="Rv3890c, (MT4005, MTCY15F10.22), len: 95 aa.
EsxC,ESAT-6 like protein (see Gey Van Pittius et al.,
2001),equivalent to Q9K548|ES6B_MYCPA putative ESAT-6 like
protein 11 (ORF3890C) from Mycobacterium paratuberculosis
(95 aa), FASTA scores: opt: 490, E(): 3.3e-26, (76.85%
identity in 95 aa overlap). Belongs to the ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv3890c"
/db_xref="EnsemblGenomes-Tr:CCP46719"
/db_xref="GOA:P9WNI1"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNI1"
/protein_id="CCP46719.1"
/translation="MSDQITYNPGAVSDFASDVGSRAGQLHMIYEDTASKTNALQEFF
AGHGAQGFFDAQAQMLSGLQGLIETVGQHGTTTGHVLDNAIGTDQAIAGLF"
gene complement(4374049..4374372)
/gene="esxD"
/locus_tag="Rv3891c"
CDS complement(4374049..4374372)
/codon_start=1
/transl_table=11
/gene="esxD"
/locus_tag="Rv3891c"
/product="Possible ESAT-6 like protein EsxD"
/note="Rv3891c, (MTCY15F10.21), len: 107 aa (first GTG
taken). EsxD, ESAT-6 like protein, equivalent to Q9K547
hypothetical 10.3 KDA protein (fragment) from
Mycobacterium paratuberculosis (100 aa), FASTA scores:
opt: 498, E(): 1.7e-26, (77.25% identity in 101 aa
overlap). Seems to belong to the ESAT6 family (see Gey Van
Pittius et al.,2001)."
/db_xref="EnsemblGenomes-Gn:Rv3891c"
/db_xref="EnsemblGenomes-Tr:CCP46720"
/db_xref="GOA:O05453"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:O05453"
/protein_id="CCP46720.1"
/translation="MADTIQVTPQMLRSTANDIQANMEQAMGIAKGYLANQENVMNPA
TWSGTGVVASHMTATEITNELNKVLTGGTRLAEGLVQAAALMEGHEADSQTAFQALFG
ASHGS"
gene complement(4374484..4375683)
/gene="PPE69"
/locus_tag="Rv3892c"
CDS complement(4374484..4375683)
/codon_start=1
/transl_table=11
/gene="PPE69"
/locus_tag="Rv3892c"
/product="PPE family protein PPE69"
/note="Rv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member
of the Mycobacterium tuberculosis PPE family of conserved
proteins, similar to many e.g. O05298|Rv1196|MTCI364.08
from Mycobacterium leprae (391 aa), FASTA scores: opt:
348,E(): 2.2e-08, (26.6% identity in 380 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3892c"
/db_xref="EnsemblGenomes-Tr:CCP46721"
/db_xref="InterPro:IPR000030"
/db_xref="InterPro:IPR038332"
/db_xref="UniProtKB/Swiss-Prot:P9WHW7"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46721.1"
/translation="MPDPGWAARTPEANDLLLTAGTGVGTHLANQTAWTTLGASHHAS
GVASAINTAATAASWLGVGSAASALNVTMLNATLHGLAGWVDVKPAVVSTAIAAFETA
NAAMRPAPECMENRDEWGVDNAINPSVLWTLTPRIVSLDVEYFGVMWPNNAAVGATYG
GVLAALAESLAIPPPVATMGASPAAPAQAAAAVGQAAAEAAAGDGMRSAYQGVQAGST
GAGQSTSAGENFGNQLSTFMQPMQAVMQAAPQALQAPSGLMQAPMSAMQPLQSMVGMF
ANPGALGMGGAAPGASAASAAGGISAAATEVGAGGGGAALGGGGMPATSFTRPVSAFE
SGTSGRPVGLRPSGALGADVVRAPTTTVGGTPIGGMPVGHAAGGHRGSHGKSEQAATV
RVVDDRR"
gene complement(4375762..4375995)
/gene="PE36"
/locus_tag="Rv3893c"
CDS complement(4375762..4375995)
/codon_start=1
/transl_table=11
/gene="PE36"
/locus_tag="Rv3893c"
/product="PE family protein PE36"
/note="Rv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member
of the Mycobacterium tuberculosis PE family of conserved
proteins (see citation below), similar to others e.g.
O53690|Rv0285|MTV035.13 from Mycobacterium tuberculosis
(102 aa), FASTA scores: opt: 136, E(): 0.042, (35.6%
identity in 73 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3893c"
/db_xref="EnsemblGenomes-Tr:CCP46722"
/db_xref="InterPro:IPR000084"
/db_xref="UniProtKB/TrEMBL:L7N660"
/protein_id="CCP46722.1"
/translation="MVWSVQPEAVLASAAAESAISAETEAAAAGAAPALLSTTPMGGD
PDSAMFSAALNACGASYLGVVAEHASQRGLFAG"
gene complement(4376262..4380452)
/gene="eccC2"
/locus_tag="Rv3894c"
CDS complement(4376262..4380452)
/codon_start=1
/transl_table=11
/gene="eccC2"
/locus_tag="Rv3894c"
/product="ESX conserved component EccC2. ESX-2 type VII
secretion system protein. Possible membrane protein."
/note="Rv3894c, (MTCY15F10.18), len: 1396 aa. EccC2, esx
conserved component, ESX-2 type VII secretion system
protein, possible membrane protein (possible transmembrane
segments from aa ~37-85), similar to Q9CD30|ML2535
hypothetical protein from Mycobacterium leprae (1329
aa),FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity
in 1425 aa overlap); Q9CDD7|ML0052 hypothetical protein
from Mycobacterium leprae (597 aa), FASTA scores: opt:
537, E(): 6.6e-24, (27.5% identity in 585 aa overlap)
(similarity only with C-terminal end);
Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane
protein from Mycobacterium leprae (1345 aa), FASTA scores:
opt: 523, E(): 8.6e-23,(31.65% identity in 1412 aa
overlap). Also similar to various proteins e.g.
O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces
coelicolor (1321 aa), FASTA scores: opt: 973, E():
2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c
putative cell division-related protein from Streptomyces
coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23,
(24.95% identity in 1450 aa overlap); Q9KE81|BH0975
hypothetical protein from Bacillus halodurans (1489 aa),
FASTA scores: opt: 444, E(): 4.1e-18,(22.5% identity in
1346 aa overlap); etc. Also similar to AAK46103|MT1833
FTSK/SPOIIIE family protein from Mycobacterium
tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt:
769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap);
and other hypothetical proteins from Mycobacterium
tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA
scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa
overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA
scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391
aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA
scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa
overlap) (similarity only with C-terminal end); etc.
Contains two possible (PS00017) ATP/GTP-binding sites
(P-loop) in central portion."
/db_xref="EnsemblGenomes-Gn:Rv3894c"
/db_xref="EnsemblGenomes-Tr:CCP46723"
/db_xref="GOA:O05450"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR023836"
/db_xref="InterPro:IPR023837"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:O05450"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46723.1"
/translation="MSKKAFPINRVNIDPPKPVRVAPNPPIALPEREPRNIWVMIGVP
ALIVALIGTIVMLYVSGVRSLATGFFPLMGIGAFSMLAFSGRFGRARKITWGELEKGR
RRYLRDLDTNRDEIQTAVCAQREWQNAVHSDPPGLGAIIGGPRMWERGRGDVDFLEVR
VGTGVQHAPDSVLSVTWPDISSDEELEPVTGQALRDFILEQRKIRDIAKVVNLRSAPG
FSFVSEDLDRVRSLMRSVLCSLAVFHNPRDVKLMVVTRNREVWAWMVWLPHNLHDELF
DACGWRRLIFATPEELEAALGAELHMKGKRGAWTPPTVASPTAMGSALETGQVGVDLG
PHLVIVDDNTGSPDAWESVVGQVGKAGLTVLRIASRVGTGVGFAEDQVFEMAQRHGAA
TAVKAGRDGADADDDQRPAPLLRARGTFFAHADQLSIHRAYRYARAMARWSPTSRSEV
TDSTSGAAELLRSLGISDPRELDVDRLWAERRGRGDDRWCEIPVGAKPNGELQNIILR
AKDFGGFGFHSVVIGTSGSGKSELFLSLVYGIALTHSPETFNVIFVDMKFESAAQDIL
GIPHVVAALSNLGKDERHLAERMRRVIDGEIKQRYELFKSVGARDANDYEEIRLAGRD
LPPVPVLLVIVDEYLELFANHKKWIDLIIHIGQEGRGANVFFMLGGQRLDLSSLQKVK
SNIAFRIALRAESGDDSREVIGSDAAYHLPSKENGFALLKVGPRDLEPFRCFYLSAPF
VVPKKKEVARTIDMTLTQPRLYDWQYQPLDAADAEALATAAAADAEPDEFLYYDDGFK
KKKIVDVLRESLYNVPHRSPRRPWLAPLEDPEPVDRLVAAYRGKPWHVDYGQNPGLMF
PVGVMDIPEESQQVVHAVDALRSNIIVVGAKQRGKTTTLMALMCSAATMYTPERVTFF
CIGGATMAQIGSLPHVTDIVSPKDAEGIERILSTMDALIDAREEAFRRAKIDMDGFRE
RRFGIGGDGVGGTDPTDAFGDVFVVLDDYDDLYAKDTLLGDRIISLSSRGPEYGVHLM
CSAGGWIHGQRQSLLQNVTARIQLRLADPGESQMGHLSIESREAARRTLNRPGFGLTE
SLHELRIGVPALADPGTGELVGITDVGARIADVAGVTKHASLQRLPQRVELSAIVEHE
AVHQGGDDLSIAFAIGERHELGPVPIKLRESPGLMILGRQGCGKTTALVAIGEAVMNR
FSPQQAQLTLIDPKTAPHGLRDLHAPGYVRAYAYDQDEIDEVITELAQQILLPRLPPK
GLSQEELRALKPWEGPRHFVLIDDVQDLRPAQSYPQKPPVGAALWKLMERARQVGLHV
FSTRNSANWATMPMDPWVKSQTSAKVAQLYMDNDPQNRINRSVRAQTLPPGRGLLVGA
DGDVEGILVGYPSVPGEQ"
gene complement(4380453..4381940)
/gene="eccB2"
/locus_tag="Rv3895c"
CDS complement(4380453..4381940)
/codon_start=1
/transl_table=11
/gene="eccB2"
/locus_tag="Rv3895c"
/product="ESX conserved component EccB2. ESX-2 type VII
secretion system protein. Probable membrane protein."
/note="Rv3895c, (MTCY15F10.17), len: 495 aa. EccB2, esx
conserved component, ESX-2 type VII secretion system
protein, probable membrane protein, highly similar to two
conserved membrane protein from Mycobacterium leprae:
Q9Z5I3|ML1544|MLCB596.27 (506 aa), FASTA scores: opt:
1070,E(): 1.4e-53, (39.8% identity in 485 aa overlap); and
Q9CD29|ML2536 (552 aa), FASTA scores: opt: 483, E():
4e-20,(36.85% identity in 499 aa overlap). Also highly
similar to various proteins from Mycobacterium
tuberculosis e.g. O53933|Rv1782|MTV049.04 hypothetical
protein (506 aa),FASTA scores: opt: 1106, E(): 1.2e-55,
(41.25% identity in 485 aa overlap);
O69734|Rv3869|MTV027.04 hypothetical protein (480 aa),
FASTA scores: opt: 795, E(): 6.1e-38,(36.0% identity in
486 aa overlap); O33088|ML0054|MLCB628.17c putative
membrane protein (481 aa), FASTA scores: opt: 740, E():
8.3e-35, (35.65% identity in 485 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3895c"
/db_xref="EnsemblGenomes-Tr:CCP46724"
/db_xref="GOA:P9WNR5"
/db_xref="InterPro:IPR007795"
/db_xref="InterPro:IPR042485"
/db_xref="UniProtKB/Swiss-Prot:P9WNR5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46724.1"
/translation="MPLSLSNRDQNSGHLFYNRRLRAATTRFSVRMKHDDRKQTAALA
LSMVLVAIAAGWMMLLNVLKPTGIVGDSAIIGDRDSGALYARIDGRLYPALNLTSARL
ATGTAGQPTWVKPAEIAKYPTGPLVGIPGAPAAMPVNRGAVSAWAVCDTAGRPRSADK
PVVTSIAGPITGGGRATHLRDDAGLLVTFDGSTYVIWGGKRSQIDPTNRAVTLSLGLD
PGVTSPIQISRALFDGLPATEPLRVPAVPEAGTPSTWVPGARVGSVLQAQTAGGGSQF
YVLLPDGVQKISSFVADLLRSANSYGAAAPRVVTPDVLVHTPQVTSLPVEYYPAGRLN
FVDTAADPTTCVSWEKASTDPQARVAVYNGRGLPVPPSMDSRIVRLVRDDRAPASVVA
TQVLVLPGAANFVTSTSGVITAESRESLFWVSGNGVRFGIANDEATLRALGLDPGAAV
QAPWPLLRTFAAGPALSRDAALLARDTVPTLGQVAIVTTTAKAGA"
gene complement(4381943..4382851)
/locus_tag="Rv3896c"
CDS complement(4381943..4382851)
/codon_start=1
/transl_table=11
/locus_tag="Rv3896c"
/product="Conserved hypothetical protein"
/note="Rv3896c, (MTCY15F10.16), len: 302 aa (first GTG
taken, although TBParse suggests TTG at 16079). Putative
conserved ala-rich protein. C-terminus highly similar to
C-terminal end of other proteins e.g. Q9XAS4|SC10A7.01
hypothetical 17.2 KDA protein from Streptomyces coelicolor
(244 aa), FASTA scores: opt: 255, E(): 1.4e-08, (32.0%
identity in 222 aa overlap); CAC44611|STBAC16H6.32
putative secreted protein from Streptomyces coelicolor
(172 aa),FASTA scores: opt: 214, E(): 3.4e-06, (42.55%
identity in 94 aa overlap); Q38352|ORF360 from Lactococcus
delbrueckii bacteriophage ll-H (360 aa), FASTA scores:
opt: 211, E(): 9.5e-06, (40.0% identity in 115 aa
overlap); P54334|XKDO_BACSU|XKDO phage-like element PBSX
protein from Bacillus subtilis (1332 aa), FASTA scores:
opt: 209, E(): 3.6e-05, (38.35% identity in 86 aa
overlap); etc. Also similar to
P71594|P71594|Rv0024|MTCY10H4.24 hypothetical 30.3 KDA
protein from Mycobacterium tuberculosis (281 aa),FASTA
scores: opt: 265, E(): 3.9e-09, (29.25% identity in 287 aa
overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3896c"
/db_xref="EnsemblGenomes-Tr:CCP46725"
/db_xref="InterPro:IPR023346"
/db_xref="UniProtKB/TrEMBL:O05448"
/protein_id="CCP46725.1"
/translation="MSTWHRIGTEGEPLTDPLTTQAIAALSRGHGLFAGGVSGADIDA
PQIQQYANAISWVANAVPTAAAYRWRGAARALRRLANTDEALAQIMAAAQIDHAHART
ATRALLEAAKTDAMALTDTPLGRREAMARMAARLRAQHRHIARCRSRARLLGLRLRRL
RYLRTAAARRPQVTTPGGRAQVLAAIQKALDIQGVHDPAARARWTRGMDLVARRESNY
NANAINHWDSNAARGTPSRGVWQFIAPTFAAYHEPGTSTNIHDLVAQACAFINYARGH
YGVAADASNLADLIQQADPRRSPRGY"
gene complement(4383008..4383640)
/locus_tag="Rv3897c"
CDS complement(4383008..4383640)
/codon_start=1
/transl_table=11
/locus_tag="Rv3897c"
/product="Conserved hypothetical protein"
/note="Rv3897c, (MTCY15F10.15), len: 210 aa. Conserved
hypothetical protein, highly similar in part to
Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 hypothetical
30.8 KDA protein from Mycobacterium tuberculosis (314 aa)
FASTA scores: opt: 815, E(): 4.7e-26, (73.05% identity in
167 aa overlap). Similarity to MTCY49.22 suggests that
this is a continuation of MTCY15F10.14. There is a
frameshift mutation near 3'-end with respect to this
sequence as well,similarity to MTCY49.22 continues in an
overlapping ORF. Sequence appears to be correct."
/db_xref="EnsemblGenomes-Gn:Rv3897c"
/db_xref="EnsemblGenomes-Tr:CCP46726"
/db_xref="UniProtKB/TrEMBL:O07036"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46726.1"
/translation="MMQQAVSGITGALGGAVGGVMGPLTQLPQQAMQAGQGAMQPLMS
ALQQTYGAEGLDVADGARLVDSIEGEPGLGGEPGAGDVGAGGGGGGTTPTGYLGPPPV
PTSSPPTTPAGAPAKSVTPDPVSGTPRASGPAGMTGMPMVPPGALGAGAEGANKDKPV
EKRVTGCAEWSTGQGPLNSTAECSGEICRRQAGGHQVDATDPCCAERRQG"
gene complement(4383653..4383985)
/locus_tag="Rv3898c"
CDS complement(4383653..4383985)
/codon_start=1
/transl_table=11
/locus_tag="Rv3898c"
/product="Conserved hypothetical protein"
/note="Rv3898c, (MTCY15F10.14), len: 110 aa. Conserved
hypothetical protein. Highly similar, but in part, to
Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 hypothetical
30.8 KDA protein from Mycobacterium tuberculosis (314 aa)
FASTA scores: opt: 204, E(): 0.00042, (50.6% identity in
81 aa overlap). Similarity suggests it should be in frame
with next ORF and that the stop codon could be read
through, the sequence appears to be correct. Homology lost
upstream at 15138 gatc sequence may suggest discontinuity
due to chimerism in cY15F10 or cY49."
/db_xref="EnsemblGenomes-Gn:Rv3898c"
/db_xref="EnsemblGenomes-Tr:CCP46727"
/db_xref="UniProtKB/TrEMBL:O05447"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46727.1"
/translation="MTGDQNPAPGPAPGVPIKVTPEILLQVLTTPPASGPAPFPAVPV
DLPAPADIANGALFAAGNSGVPGDVESSGLEDLDRRAHAADAVQKFSANEADAAQQFQ
GVGAQAEA"
gene complement(4384147..4385379)
/locus_tag="Rv3899c"
CDS complement(4384147..4385379)
/codon_start=1
/transl_table=11
/locus_tag="Rv3899c"
/product="Conserved hypothetical protein"
/note="Rv3899c, (MTCY15F10.13), len: 410 aa. Conserved
hypothetical protein, similar in part to proteins from
Mycobacterium tuberculosis strains H37Rv and CDC1551.
Region between aa 29-80 is strictly identical to P96909
hypothetical 15.1 KDA protein (fragment) (143 aa) FASTA
scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa
overlap); and the N-terminal end is highly similar, but
longer 65 aa, to O07266 hypothetical 13.7 KDA protein
(fragment) (143 aa), FASTA scores: opt: 562, E():
4e-16,(69.0% identity in 142 aa overlap). Highly similar
to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21
hypothetical 73.6 KDA protein (721 aa), FASTA scores: opt:
1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap).
And similar to P71599|Rv0029|MTCY10H4.29 hypothetical 39.6
KDA protein (365 aa), FASTA scores: opt: 403, E():
1.7e-09,(33.75% identity in 252 aa overlap). Note that
MTCY15F10.12 and MTCY15F10.13 appear frameshifted with
respect to MTCY49.21 although the sequence appears to be
correct."
/db_xref="EnsemblGenomes-Gn:Rv3899c"
/db_xref="EnsemblGenomes-Tr:CCP46728"
/db_xref="GOA:O05446"
/db_xref="InterPro:IPR040604"
/db_xref="InterPro:IPR040833"
/db_xref="PDB:5IMU"
/db_xref="UniProtKB/TrEMBL:O05446"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46728.1"
/translation="MVTGQPAAAGAHSLSEGAMTAMQSGSVPPPQATPPITTPPVVSA
PTMAAGIEATHGPVDTPANTSGAPPASTGTTGPVAPTVVTAGPVAAPAAPVVGGSAVP
AGPLPAYGSDLRPPVVAAPAVPSVPTAPVSGAPVAPSASSAPSAGGALVSPVERAASK
AVAGQAGASSSTMAGASALSATAGATAGAVSARAAEQQRLQRIVDAVARQEPRISWAA
GLRDDGTTTLLVTDLAGGWIPPHVRLPANVTLLEPTARRRDADVIDLLGAVVAVAAHE
SNTYVAEPGPDAPALTGDRSARSAIPKVDEFGPTLVEAVRRRDSLPRIAQAIALPAVR
KTGVLENEAELLHGCITAVKESVLKAYPSHELTAVGDWMLLAAIEALIDEQDYLANYH
LAWYAVTTRRGGSRGFAA"
gene complement(4385373..4386308)
/locus_tag="Rv3900c"
CDS complement(4385373..4386308)
/codon_start=1
/transl_table=11
/locus_tag="Rv3900c"
/product="Conserved hypothetical alanine rich protein"
/note="Rv3900c, (MTCY15F10.12), len: 311 aa. Conserved
hypothetical ala-rich protein, highly similar to
N-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21
hypothetical 73.6 KDA protein from Mycobacterium
tuberculosis (721 aa), FASTA scores: opt: 592, E():
2.7e-22, (37.15% identity in 280 aa overlap). Note that
MTCY15F10.12 and MTCY15F10.13 appear frameshifted with
respect to MTCY49.21 although the sequence appears to be
correct. This region is a possible MT-complex-specific
genomic island (See Becq et al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3900c"
/db_xref="EnsemblGenomes-Tr:CCP46729"
/db_xref="GOA:O05445"
/db_xref="UniProtKB/TrEMBL:O05445"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46729.1"
/translation="MVAADLPPGRWSAVLVGPWWPAPSAALRAAAQHWATWAMQKQEL
ARNLISQHDLLLRNQGRTAEDLIGRYLRGAKSEVTKAEKYEIKKGAFNTAADAIDYLR
SRLTGIAGEGNKEIDDVLASKKPLPEQLAEIQAIQTRCNADAANASRDAVDKVMTAMQ
EILEAEDIGDDPRTWARANGFNVDDAPPPRLIRENDLAALTGPGARGGSFGSVEGAGD
LASPQSVGAGGFSGSGVQAACSQPAPRAIGASSRHASAGPVPPAPVVTTPAAATPPVI
ATGPRWRCPAGRCRRRPSDRAYRLRRLGNRLRPGW"
gene complement(4386365..4386814)
/locus_tag="Rv3901c"
CDS complement(4386365..4386814)
/codon_start=1
/transl_table=11
/locus_tag="Rv3901c"
/product="Possible membrane protein"
/note="Rv3901c, (MTCY15F10.11), len: 149 aa. Possible
membrane protein (hydrophobic stretch from ~30-52),
showing some similarity with O53200|Rv2473|MTV008.29
hypothetical 25.1 KDA protein from Mycobacterium
tuberculosis (238 aa),FASTA scores: opt: 147, E(): 0.036,
(31.35% identity in 134 aa overlap). This region is a
possible MT-complex-specific genomic island (See Becq et
al., 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3901c"
/db_xref="EnsemblGenomes-Tr:CCP46730"
/db_xref="GOA:O05444"
/db_xref="UniProtKB/TrEMBL:O05444"
/protein_id="CCP46730.1"
/translation="MQAANRRSADTICGVTAPAPLPIPRTRSWPAIVVAAIAAVVAVA
ALIVALTNARPAATPATTSVPTYTAAQTAAAQRQLCDTYKLVAHAVPVDTNGSDKALA
RITLTNAAAILDNAAADPALDAKHRDAARASDRLPHNDRNGEWWHSS"
gene complement(4387365..4387895)
/locus_tag="Rv3902c"
CDS complement(4387365..4387895)
/codon_start=1
/transl_table=11
/locus_tag="Rv3902c"
/product="Hypothetical protein"
/note="Rv3902c, (MTCY15F10.10), len: 176 aa. Hypothetical
unknown protein. This region is a possible
MT-complex-specific genomic island (See Becq et
al.,2007)."
/db_xref="EnsemblGenomes-Gn:Rv3902c"
/db_xref="EnsemblGenomes-Tr:CCP46731"
/db_xref="GOA:O05443"
/db_xref="InterPro:IPR028953"
/db_xref="PDB:4QLP"
/db_xref="UniProtKB/Swiss-Prot:O05443"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46731.1"
/translation="MTIGVDLSTDLQDWIRLSGMNMIQGSETNDGRTILWNKGGEVRY
FIDRLAGWYVITSSDRMSREGYEFAAASMSVIEKYLYGYFGGSVRSERELPAIRAPFQ
PEELMPEYSIGTMTFAGRQRDTLIDSSGTVVAITAADRLVELSHYLDVSVNVIKDSFL
DSEGKPLFTLWKDYKG"
gene complement(4387892..4390432)
/locus_tag="Rv3903c"
CDS complement(4387892..4390432)
/codon_start=1
/transl_table=11
/locus_tag="Rv3903c"
/product="Hypothetical alanine and proline rich protein"
/note="Rv3903c, (MTCY15F10.08), len: 846 aa. Hypothetical
unknown ala-, pro-rich protein."
/db_xref="EnsemblGenomes-Gn:Rv3903c"
/db_xref="EnsemblGenomes-Tr:CCP46732"
/db_xref="GOA:O05442"
/db_xref="InterPro:IPR025331"
/db_xref="PDB:4QLP"
/db_xref="UniProtKB/Swiss-Prot:O05442"
/protein_id="CCP46732.1"
/translation="MAPLAVDPAALDSAGGAVVAAGAGLGAVISSLTAALAGCAGMAG
DDPAGAVFGRSYDGSAAALVQAMSVARNGLCNLGDGVRMSAHNYSLAEAMSDVAGRAA
PLPAPPPSGCVGVGAPPSAVGGGGGAPKGWGWVAPYIGMIWPNGDSTKLRAAAVAWRS
AGTQFALTEIQSTAGPMGVIRAQQLPEAGLIESAFADAYASTTAVVGQCHQLAAQLDA
YAARIDAVHAAVLDLLARICDPLTGIKEVWEFLTDQDEDEIQRIAHDIAVVVDQFSGE
VDALAAEITAVVSHAEAVITAMADHAGKQWDRFLHSNPVGVVIDGTGQQLKGFGEEAF
GMAKDSWDLGPLRASIDPFGWYRSWEEMLTGMAPLAGLGGENAPGVVESWKQFGKSLI
HWDEWTTNPNEALGKTVFDAATLALPGGPLSKLGSKGRDILAGVRGLKERLEPTTPHL
EPPATPPRPGPQPPRIEPPESGHPAPAPAAKPAPVPANGPLPHSPTESKPPPVDRPAE
PVAPSSASAGQPRVSAATTPGTHVPHGLPQPGEHVPAQAPPATTLLGGPPVESAPATA
HQPQWATTPAAPAAAPHSTPGGVHSTESGPHGRSLSAHGSEPTHDGASHGSGHGSGSE
PPGLHAPHREQQLAMHSNEPAGEGWHRLSDEAVDPQYGEPLSRHWDFTDNPADRSRIN
PVVAQLMEDPNAPFGRDPQGQPYTQERYQERFNSVGPWGQQYSNFPPNNGAVPGTRIA
YTNLEKFLSDYGPQLDRIGGDQGKYLAIMEHGRPASWEQRALHVTSLRDPYHAYTIDW
LPEGWFIEVSEVAPGCGQPGGSIQVRIFDHQNEMRKVEELIRRGVLRQ"
gene complement(4390437..4390709)
/gene="esxE"
/gene_synonym="ES6_12"
/locus_tag="Rv3904c"
CDS complement(4390437..4390709)
/codon_start=1
/transl_table=11
/gene="esxE"
/gene_synonym="ES6_12"
/locus_tag="Rv3904c"
/product="Putative ESAT-6 like protein EsxE (hypothetical
alanine rich protein) (ESAT-6 like protein 12)"
/note="Rv3904c, (MT4023, MTCY15F10.07), len: 90 aa.
EsxE,ESAT-6 like protein, hypothetical unknown ala-rich
protein. Belongs to the ESAT6 family (see citation
below)."
/db_xref="EnsemblGenomes-Gn:Rv3904c"
/db_xref="EnsemblGenomes-Tr:CCP46733"
/db_xref="GOA:P9WNH9"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNH9"
/protein_id="CCP46733.1"
/translation="MDPTVLADAVARMAEFGRHVEELVAEIESLVTRLHVTWTGEGAA
AHAEAQRHWAAGEAMMRQALAQLTAAGQSAHANYTGAMATNLGMWS"
gene complement(4390720..4391031)
/gene="esxF"
/gene_synonym="ES6_13"
/locus_tag="Rv3905c"
CDS complement(4390720..4391031)
/codon_start=1
/transl_table=11
/gene="esxF"
/gene_synonym="ES6_13"
/locus_tag="Rv3905c"
/product="Putative ESAT-6 like protein EsxF (hypothetical
alanine and glycine rich protein) (ESAT-6 like protein
13)"
/note="Rv3905c, (MT4024, MTCY15F10.06), len: 103 aa.
EsxF,ESAT-6 like protein (see citation below),
hypothetical unknown ala-, gly-rich protein, ESAT-6 like
protein. Belongs to the ESAT6 family."
/db_xref="EnsemblGenomes-Gn:Rv3905c"
/db_xref="EnsemblGenomes-Tr:CCP46734"
/db_xref="GOA:P9WNH7"
/db_xref="InterPro:IPR010310"
/db_xref="InterPro:IPR036689"
/db_xref="UniProtKB/Swiss-Prot:P9WNH7"
/protein_id="CCP46734.1"
/translation="MGADDTLRVEPAVMQGFAASLDGAAEHLAVQLAELDAQVGQMLG
GWRGASGSAYGSAWELWHRGAGEVQLGLSMLAAAIAHAGAGYQHNETASAQVLREVGG
G"
gene complement(4391097..4391606)
/locus_tag="Rv3906c"
CDS complement(4391097..4391606)
/codon_start=1
/transl_table=11
/locus_tag="Rv3906c"
/product="Conserved hypothetical protein"
/note="Rv3906c, (MTCY15F10.05), len: 169 aa. Conserved
hypothetical protein, strongly related to Q50578|AT9S (sod
related in Escherichia coli) from Mycobacterium
tuberculosis strain aoyama B (155 aa), but apparently
different as flanking sequences differ and shorter 43
aa,FASTA scores: opt: 548, E(): 1.3e-26, (79.4% identity
in 102 aa overlap). Selfmarch results suggest that Rv3906c
is not related to any other hypothetical protein from
Mycobacterium tuberculosis strain H37Rv except itself.
Shows also similarity with Q9VFR2|CG9297 hypothetical
protein from Drosophila melanogaster (Fruit fly) (930
aa),FASTA scores: opt: 221, E(): 4.9e-06, (36.95% identity
in 157 aa overlap); Q9HQ55|CBP|VNG1320G calcium-binding
protein homology from Halobacterium sp. strain NRC-1 (385
aa) FASTA scores: opt: 143, E(): 0.13, (35.65% identity in
160 aa overlap); Q24795 calcium-binding protein (fragment)
from Echinococcus granulosus (338 aa), FASTA scores: opt:
140, E(): 0.17, (33.95% identity in 156 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3906c"
/db_xref="EnsemblGenomes-Tr:CCP46735"
/db_xref="GOA:O05439"
/db_xref="InterPro:IPR028974"
/db_xref="UniProtKB/TrEMBL:O05439"
/protein_id="CCP46735.1"
/translation="MEYCIAGDDGSAGIWNRPFDVDLDGDGRLDAIGLDLDGDGLRDD
ALADFDGDDVADHAVFDVDNDGTPESYFIDDGSGTWAVAVDRGGQLRWYGLDGVEHTG
GPLVDFDGFGGLDDRLLDTDGDGLADRVLCAGEQRVTGYVDTDGDGRWDVRLTDTDGD
GTADGASSL"
gene complement(4391631..4393073)
/gene="pcnA"
/locus_tag="Rv3907c"
CDS complement(4391631..4393073)
/codon_start=1
/transl_table=11
/gene="pcnA"
/locus_tag="Rv3907c"
/product="Probable poly(A) polymerase PcnA (polynucleotide
adenylyltransferase) (NTP polymerase) (RNA adenylating
enzyme) (poly(A) polymerase)"
/note="Rv3907c, (MTCY15F10.04), len: 480 aa. Probable
pcnA,polynucleotide polymerase, equivalent to
Q9CCY1|PCNA|ML2697 PCNA protein from Mycobacterium leprae
(486 aa), FASTA scores: opt: 2713, E(): 4.3e-160, (84.1%
identity in 478 aa overlap); and Q59534|PCNB POLYA
polymerase from Mycobacterium leprae (411 aa) FASTA
scores: opt: 2077, E(): 7.1e-121, (82.55% identity in 373
aa overlap). Also highly similar to many e.g.
Q9X8T2|SCH24.18 putative RNA nucleotidyltransferase from
Streptomyces coelicolor (483 aa), FASTA scores: opt: 1856,
E(): 3.7e-107, (61.55% identity in 455 aa overlap); Q9ZN65
POLYA polymerase from Prevotella ruminicola (Bacteroides
ruminicola) (479 aa),FASTA scores: opt: 830, E(): 8.5e-44,
(34.85% identity in 445 aa overlap); P42977|PAPS_BACSU
poly(A) polymerase from Bacillus subtilis (397 aa), FASTA
scores: opt: 479, E(): 3.5e-22, (29.35% identity in 450 aa
overlap); etc. Contains: PS00017 ATP/GTP-binding site
motif A (P-loop),PS00018 EF-hand calcium-binding domain,
and probably less significant a PS00237 G-protein coupled
receptor signature,and PS00639 Eukaryotic thiol (cysteine)
proteases histidine active site. Belongs to the tRNA
nucleotidyltransferase / poly(A) polymerase family."
/db_xref="EnsemblGenomes-Gn:Rv3907c"
/db_xref="EnsemblGenomes-Tr:CCP46736"
/db_xref="GOA:L7N672"
/db_xref="InterPro:IPR002646"
/db_xref="InterPro:IPR003607"
/db_xref="InterPro:IPR006674"
/db_xref="InterPro:IPR006675"
/db_xref="InterPro:IPR014065"
/db_xref="InterPro:IPR032828"
/db_xref="UniProtKB/TrEMBL:L7N672"
/inference="protein motif:PROSITE:PS00018"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00639"
/inference="protein motif:PROSITE:PS00237"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46736.1"
/translation="MPEAVQEADLLTAAAVALNRHAALLRELGSVFAAAGHELYLVGG
SVRDALLGRLSPDLDFTTDARPERVQEIVRPWADAVWDTGIEFGTVGVGKSDHRMEIT
TFRADSYDRVSRHPEVRFGDCLEGDLVRRDFTTNAMAVRVTATGPGEFLDPLGGLAAL
RAKVLDTPAAPSGSFGDDPLRMLRAARFVSQLGFAVAPRVRAAIEEMAPQLARISAER
VAAELDKLLVGEDPAAGIDLMVQSGMGAVVLPEIGGMRMAIDEHHQHKDVYQHSLTVL
RQAIALEDDGPDLVLRWAALLHDIGKPATRRHEPDGGVSFHHHEVVGAKMVRKRMRAL
KYSKQMIDDISQLVYLHLRFHGYGDGKWTDSAVRRYVTDAGALLPRLHKLVRADCTTR
NKRRAARLQASYDRLEERIAELAAQEDLDRVRPDLDGNQIMAVLDIPAGPQVGEAWRY
LKELRLERGPLSTEEATTELLSWWKSRGNR"
gene 4393449..4394195
/gene="mutT4"
/locus_tag="Rv3908"
CDS 4393449..4394195
/codon_start=1
/transl_table=11
/gene="mutT4"
/locus_tag="Rv3908"
/product="Possible mutator protein MutT4"
/note="Rv3908, (MTCY15F10.03c), len: 248 aa. Possible
mutT4, mutator protein, equivalent to
Q50195|ML2698|L222-ORF6 hypothetical protein from
Mycobacterium leprae (251 aa), FASTA scores: opt:
1270,E(): 3.4e-62, (79.05% identity in 248 aa overlap).
Also similar to O66548|APFA|AQ_158 hydrolase from Aquifex
aeolicus (134 aa), FASTA scores: opt: 300, E():
1.1e-09,(37.3% identity in 142 aa overlap); and similarity
with other various proteins e.g. O93721 diadenosine
5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase from
Pyrobaculum aerophilum (143 aa), FASTA scores: opt:
205,E(): 0.00017, (34.85% identity in 109 aa overlap);
Q9HS29|APA|VNG0431G diadenosine tetraphosphate
pyrophosphohydrolase from Halobacterium sp. strain NRC-1
(142 aa), FASTA scores: opt: 199, E(): 0.00036, (34.0%
identity in 147 aa overlap); Q9YA58|APE2080 hypothetical
19.2 KDA protein from Aeropyrum pernix (175 aa) FASTA
scores: opt: 191, E(): 0.0012, (36.9% identity in 141 aa
overlap); etc. Also similar to
P95110|MUTT1|Rv2985|MTCY349.02 hypothetical 34.7 KDA
protein from Mycobacterium tuberculosis (317 aa) FASTA
scores: opt: 224, E(): 3e-05, (34.05% identity in 144 aa
overlap). Predicted to be an outer membrane protein (See
Song et al., 2008). Seems to belong to the NUDIX hydrolase
family."
/db_xref="EnsemblGenomes-Gn:Rv3908"
/db_xref="EnsemblGenomes-Tr:CCP46737"
/db_xref="GOA:P9WIX7"
/db_xref="InterPro:IPR000086"
/db_xref="InterPro:IPR015797"
/db_xref="InterPro:IPR020084"
/db_xref="InterPro:IPR020476"
/db_xref="UniProtKB/Swiss-Prot:P9WIX7"
/inference="protein motif:PROSITE:PS00893"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46737.1"
/translation="MSDGEQAKSRRRRGRRRGRRAAATAENHMDAQPAGDATPTPATA
KRSRSRSPRRGSTRMRTVHETSAGGLVIDGIDGPRDAQVAALIGRVDRRGRLLWSLPK
GHIELGETAEQTAIREVAEETGIRGSVLAALGRIDYWFVTDGRRVHKTVHHYLMRFLG
GELSDEDLEVAEVAWVPIRELPSRLAYADERRLAEVADELIDKLQSDGPAALPPLPPS
SPRRRPQTHSRARHADDSAPGQHNGPGPGP"
gene 4394192..4396600
/locus_tag="Rv3909"
CDS 4394192..4396600
/codon_start=1
/transl_table=11
/locus_tag="Rv3909"
/product="Conserved protein"
/note="Rv3909, (MTCY15F10.02c), len: 802 aa. Conserved
protein, equivalent to Q9CCY0|ML2699 putative secreted
protein from Mycobacterium leprae (797 aa) FASTA scores:
opt: 3777, E(): 8.8e-206, (72.35% identity in 803 aa
overlap). Note that the N-terminal end is highly similar
to Q50196|L222-ORF7 (286 aa), FASTA scores: opt: 1213,
E(): 2.7e-61, (71.75% identity in 255 aa overlap); and the
C-terminal end is highly similar to Q50197|L222-ORF8 also
from Mycobacterium leprae (512 aa) FASTA scores: opt:
2375,E(): 9.9e-127, (71.8% identity in 518 aa overlap).
Shows some similarity with N-terminal end of Q9I2M3|PA1874
hypothetical protein from Pseudomonas aeruginosa (2468
aa),FASTA scores: opt: 171, E(): 0.13, (22.9% identity in
672 aa overlap). Predicted to be an outer membrane protein
(See Song et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv3909"
/db_xref="EnsemblGenomes-Tr:CCP46738"
/db_xref="GOA:O05436"
/db_xref="UniProtKB/TrEMBL:O05436"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46738.1"
/translation="MTALQLGWAALARVTSAIGVVAGLGMALTVPSAAPHALAGEPSP
TPFVQVRIDQVTPDVVTTSSEPHVTVSGTVTNTGDRPVRDVMVRLEHAAAVTSSTALR
TSLDGGTDQYQPAADFLTVAPELDRGQEAGFTLSAPLRSLTRPSLAVNQPGIYPVLVN
VNGTPDYGAPARLDNARFLLPVVGVPPDQATDFGSAVAPETTAPVWITMLWPLADRPR
LAPGAPGGTVPVRLVDDDLANSLANGGRLDILLSAAEFATNREVDPDGAVGRALCLAI
DPDLLITVNAMTGGYVVSDSPDGAAQLPGTPTHPGTGQAAASSWLDRLRTLVHRTCVT
PLPFAQADLDALQRVNDPRLSAIATISPADIVDRILDVSSTRGATVLPDGPLTGRAIN
LLSTHGNTVAVAAADFSPEEQQGSSQIGSALLPATAPRRLSPRVVAAPFDPAVGAALA
AAGTNPTVPTYLDPSLFVRIAHESITARRQDALGAMLWRSLEPNAAPRTQILVPPASW
SLASDDAQVILTALATAIRSGLAVPRPLPAVIADAAARTEPPEPPGAYSAARGRFNDD
ITTQIGGQVARLWKLTSALTIDDRTGLTGVQYTAPLREDMLRALSQSLPPDTRNGLAQ
QRLAVVGKTIDDLFGAVTIVNPGGSYTLATEHSPLPLALHNGLAVPIRVRLQVDAPPG
MTVADVGQIELPPGYLPLRVPIEVNFTQRVAVDVSLRTPDGVALGEPVRLSVHSNAYG
KVLFAITLSAAAVLVTLAGRRLWHRFRGQPDRADLDRPDLPTGKHAPQRRAVASRDDE
KHRV"
gene 4396597..4400151
/locus_tag="Rv3910"
CDS 4396597..4400151
/codon_start=1
/transl_table=11
/locus_tag="Rv3910"
/product="Probable conserved transmembrane protein"
/note="Rv3910, (MTCY15F10.01c.MTV028.01), len: 1184 aa.
Probable conserved transmembrane protein (hydrophobic
domain ~50-550), equivalent to Q9CCX9|ML2700 possible
conserved membrane protein from Mycobacterium leprae (1206
aa), FASTA scores: opt: 5554, E(): 0, (75.15% identity in
1182 aa overlap); and highly similar, but shorter 380
aa,to Q50199|L222-ORF10 from Mycobacterium leprae (784 aa)
FASTA scores: opt: 3297, E(): 5.5e-170, (68.8% identity in
769 aa overlap); and at the N-terminal end with
Q50198|L222-ORF also from Mycobacterium leprae (379 aa)
FASTA scores: opt: 1955, E(): 5.7e-98, (88.4% identity in
353 aa overlap) (ORFs 9 and 10 are adjacent on L222). Also
similar in part (principally at the N-terminal end) to
other membrane proteins e.g. Q9X8T0|SCH24.16c putative
transmembrane protein from Streptomyces coelicolor (811
aa), FASTA scores: opt: 573, E(): 2.8e-23, (31.05%
identity in 573 aa overlap); O05467|MVIN_RHITR integral
membrane protein virulence factor MVIN homolog from
Rhizobium tropici (533 aa), FASTA scores: opt: 468, E():
9e-18,(27.1% identity in 524 aa overlap);
P56882|MVIN_RHIME integral membrane protein virulence
factor MVIN homolog from Rhizobium meliloti (Sinorhizobium
meliloti) (535 aa),FASTA scores: opt: 453, E(): 5.8e-17,
(26.2% identity in 557 aa overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3910"
/db_xref="EnsemblGenomes-Tr:CCP46739"
/db_xref="GOA:P9WJK3"
/db_xref="InterPro:IPR004268"
/db_xref="InterPro:IPR011009"
/db_xref="PDB:3OTV"
/db_xref="PDB:3OUK"
/db_xref="PDB:3OUN"
/db_xref="PDB:3UQC"
/db_xref="UniProtKB/Swiss-Prot:P9WJK3"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46739.1"
/translation="MRPSPGEVPTASQRQPELSDAALVSHSWAMAFATLISRITGFAR
IVLLAAILGAALASSFSVANQLPNLVAALVLEATFTAIFVPVLARAEQDDPDGGAAFV
RRLVTLATTLLLGATTLSVLAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLS
SVFMAILNTRNVFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGI
GTTAGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQLGLVVG
NRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAADDTPAVLADLS
LATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDVDAGYLGAAIALSAFTLIPYAL
VLLQLRVFYAREQPWTPITIIVVITGVKILGSLLAPHITGDPQLVAAYLGLANGLGFL
AGTIVGYYILRRALRPDGGQLIGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTA
HAGSVGSLLRLSVLALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQTQN
VLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGRAKGPEVIDRPSEN
ASFGAASGAELPRPVADELQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPIAFDA
LREPDRESSAPPDDVQLVPGARIANGRYRLLIFHGGVPPLQFWQALDTALDRQVALTF
VDPQGVLPDDVLQETLSRTLRLSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEV
ADTSPSPVGAIRAMQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDA
NPQDDIRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPFQIS
AVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDEAPVSAAPRTSAPNSETY
TRRRRNLLIGIGAGAAVLMVALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAAS
SAPPGSVVKPTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPSFKNGV
GLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATALRPGHNTI
SVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS"
gene 4400186..4400854
/gene="sigM"
/locus_tag="Rv3911"
CDS 4400186..4400854
/codon_start=1
/transl_table=11
/gene="sigM"
/locus_tag="Rv3911"
/product="Possible alternative RNA polymerase sigma factor
SigM"
/note="Rv3911, (MTV028.02), len: 222 aa. Possible
sigM,alternative RNA polymerase sigma factor (see Gomez et
al.,1997; Chen et al., 2000), highly similar to others
e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) putative RNA
polymerase sigma factor from Streptomyces coelicolor (236
aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity
in 212 aa overlap); Q98KG8|MLR1481 probable RNA polymerase
sigma subunit from Rhizobium loti (Mesorhizobium loti)
(307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95%
identity in 179 aa overlap); Q9A4S9|CC2751 putative RNA
polymerase sigma factor from Caulobacter crescentus (186
aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95%
identity in 138 aa overlap); etc. Also similarity with
other mycobacterial factors e.g.
O06289|SIGE|Rv1221|MTCI61.04 putative RNA polymerase sigma
factor from Mycobacterium tuberculosis (257 aa), FASTA
scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa
overlap); and O05735|SIGE putative RNA polymerase sigma
factor from Mycobacterium avium (251 aa),FASTA scores:
opt: 192, E(): 0.00014, (33.15% identity in 163 aa
overlap). Equivalent to AAK48395|MT4030 RNA polymerase
sigma-70 factor from Mycobacterium tuberculosis strain
CDC1551 (196 aa) but without similarity at the C-terminal
end. Belongs to the sigma-70 factor family, ECF
subfamily."
/db_xref="EnsemblGenomes-Gn:Rv3911"
/db_xref="EnsemblGenomes-Tr:CCP46740"
/db_xref="GOA:O53590"
/db_xref="InterPro:IPR007627"
/db_xref="InterPro:IPR013249"
/db_xref="InterPro:IPR013324"
/db_xref="InterPro:IPR013325"
/db_xref="InterPro:IPR014284"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR039425"
/db_xref="UniProtKB/Swiss-Prot:O53590"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46740.1"
/translation="MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHH
RQLHRLARLTSRTSEDADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACLDRLR
RAKAHPTAPLEDVYPVADRTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTR
PDAGRGRGHRQEPLRPGAGPPSAAAGLSQHRGEHPALTPLPVRRSIDPRARRYPTSGY
CHRA"
gene 4400870..4401634
/locus_tag="Rv3912"
CDS 4400870..4401634
/codon_start=1
/transl_table=11
/locus_tag="Rv3912"
/product="Hypothetical alanine rich protein"
/note="Rv3912, (MTV008.03), len: 254 aa. Hypothetical
unknown ala-rich protein. Cleaved by Rip|Rv2869c, in M.
tuberculosis Erdman (See Sklar et al., 2010)."
/db_xref="EnsemblGenomes-Gn:Rv3912"
/db_xref="EnsemblGenomes-Tr:CCP46741"
/db_xref="GOA:P9WJ65"
/db_xref="UniProtKB/Swiss-Prot:P9WJ65"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46741.1"
/translation="MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRV
RSDPQAQQILRALNRVRRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAH
AARPHVHPVRMIAGAAGLCAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPL
SRPQVLDLLHHTPDYGPPGGPLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVL
LVIPADTPDKLAVFAVAPHCSAADTGLLASTVVPRA"
gene 4401728..4402735
/gene="trxB2"
/gene_synonym="trxR"
/locus_tag="Rv3913"
CDS 4401728..4402735
/codon_start=1
/transl_table=11
/gene="trxB2"
/gene_synonym="trxR"
/locus_tag="Rv3913"
/product="Probable thioredoxin reductase TrxB2 (TRXR)
(TR)"
/note="Rv3913, (MT4032, MTV028.04), len: 335 aa. Probable
trxB2, thioredoxin reductase (see citation
below),equivalent to O30973|TRXB_MYCSM thioredoxin
reductase from Mycobacterium smegmatis (311 aa), FASTA
scores: opt: 1575,E(): 1.8e-87, (78.35% identity in 305 aa
overlap); and highly similar, but shorter at C-terminus,
to P46843|TRXB_MYCLE|TRXB/a|TRX|ML2703 bifunctional
thioredoxin reductase/thioredoxin from Mycobacterium
leprae (458 aa), FASTA scores: opt: 1766, E(): 8.7e-99,
(83.25% identity in 328 aa overlap). Also highly similar
to many e.g. P52215|TRXB_STRCO|SCH24.12 from Streptomyces
coelicolor (321 aa), FASTA scores: opt: 1249, E():
7.2e-68,(60.4% identity in 313 aa overlap);
Q9Z8M4|TRXB_CHLPN from Chlamydia pneumoniae (Chlamydophila
pneumoniae) (311 aa),FASTA scores: opt: 978, E(): 1.3e-51,
(49.85% identity in 307 aa overlap);
P09625|TRXB_ECOLI|B0888 from Escherichia coli strain K12
(320 aa), FASTA scores: opt: 948, E(): 8.6e-50, (49.2%
identity in 309 aa overlap); etc. Contains PS00573
Pyridine nucleotide-disulphide oxidoreductases class-II
active site. Belongs to the pyridine nucleotide-disulfide
oxidoreductases class-II. Cofactor: FAD (by similarity)."
/db_xref="EnsemblGenomes-Gn:Rv3913"
/db_xref="EnsemblGenomes-Tr:CCP46742"
/db_xref="GOA:P9WHH1"
/db_xref="InterPro:IPR005982"
/db_xref="InterPro:IPR008255"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="PDB:2A87"
/db_xref="UniProtKB/Swiss-Prot:P9WHH1"
/inference="protein motif:PROSITE:PS00573"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46742.1"
/translation="MTAPPVHDRAHHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFE
GTSFGGALMTTTDVENYPGFRNGITGPELMDEMREQALRFGADLRMEDVESVSLHGPL
KSVVTADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAV
IGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVD
GDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQGRTT
STSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAATGEADSTDALIGAQ
R"
gene 4402732..4403082
/gene="trxC"
/gene_synonym="mpt46"
/gene_synonym="trx"
/gene_synonym="trxA"
/locus_tag="Rv3914"
CDS 4402732..4403082
/codon_start=1
/transl_table=11
/gene="trxC"
/gene_synonym="mpt46"
/gene_synonym="trx"
/gene_synonym="trxA"
/locus_tag="Rv3914"
/product="Thioredoxin TrxC (TRX) (MPT46)"
/note="Rv3914, (MT4033, MTV028.05), len: 116 aa. TrxC
(alternate gene names: mpt46, trx, trxA *), thioredoxin
(see citations below), equivalent to
O30974|THIO_MYCSM|TRXA thioredoxin from Mycobacterium
smegmatis (112 aa), FASTA scores: opt: 576, E(): 2.1e-32,
(80.2% identity in 111 aa overlap); and also equivalent to
C-terminal end of P46843|TRXB_MYCLE|TRXB/a|TRX|ML2703
bifunctional thioredoxin reductase/thioredoxin from
Mycobacterium leprae (458 aa), FASTA scores: opt: 628,
E(): E(): 2e-35, (82.9% identity in 117 aa overlap). Also
highly similar to many e.g. P80579|THIO_ALIAC from
Alicyclobacillus acidocaldarius (Bacillus acidocaldarius)
(105 aa), FASTA scores: opt: 411,E(): 3e-21, (57.15%
identity in 105 aa overlap); P00275|THI1_CORNE from
Corynebacterium nephridii (105 aa),FASTA scores: opt: 394,
E(): 4.3e-20, (56.7% identity in 97 aa overlap);
P00274|THIO_ECOLI|TRXA|TSNC|FIPA|B3781 from Escherichia
coli and Salmonella typhimurium strain K12 and LT2
respectively (108 aa), FASTA scores: opt: 364, E():
4.7e-18, (54.45% identity in 101 aa overlap); etc. Also
similar to O53162|TRXB|Rv1471|MTV007.18 thioredoxin from
Mycobacterium tuberculosis (123 aa), FASTA scores: E():
2.3e-15, (41.9% identity in 93 aa overlap). Contains
PS00194 Thioredoxin family active site. Belongs to the
thioredoxin family. The product of this CDS is supposedly
secreted. In this case, this protein could exert its free
radical scavenging activity inside macrophages. (*)
Warning: note that Rv1470|MTV007.17 correspond also to
trxA."
/db_xref="EnsemblGenomes-Gn:Rv3914"
/db_xref="EnsemblGenomes-Tr:CCP46743"
/db_xref="GOA:P9WG67"
/db_xref="InterPro:IPR005746"
/db_xref="InterPro:IPR013766"
/db_xref="InterPro:IPR017937"
/db_xref="InterPro:IPR036249"
/db_xref="PDB:2I1U"
/db_xref="PDB:2L4Q"
/db_xref="PDB:2L59"
/db_xref="PDB:3O6T"
/db_xref="UniProtKB/Swiss-Prot:P9WG67"
/inference="protein motif:PROSITE:PS00194"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46743.1"
/translation="MTDSEKSATIKVTDASFATDVLSSNKPVLVDFWATWCGPCKMVA
PVLEEIATERATDLTVAKLDVDTNPETARNFQVVSIPTLILFKDGQPVKRIVGAKGKA
ALLRELSDVVPNLN"
gene 4403192..4404412
/gene_synonym="cwlM"
/locus_tag="Rv3915"
CDS 4403192..4404412
/codon_start=1
/transl_table=11
/gene_synonym="cwlM"
/locus_tag="Rv3915"
/product="Probable peptidoglycan hydrolase"
/note="Rv3915, (MTV028.06), len: 406 aa. Probable
peptidoglycan hydrolase, equivalent to Q9CCX8|ML2704
putative hydrolase from Mycobacterium leprae (406 aa)
FASTA scores: opt: 2341, E(): 2.7e-138, (86.95% identity
in 406 aa overlap); the N-terminal end is highly similar
to Q59535 N-acetymuramyl-L-alanine amidase from
Mycobacterium leprae (205 aa), FASTA scores: opt: 1046,
E(): 5.7e-58, (84.85% identity in 185 aa overlap). Also
similar to other hydrolases (especially amidases) e.g.
C-terminal end of Q9K6R3|LYTC|BH3665
N-acetylmuramoyl-L-alanine amidase (major autolysin) from
Bacillus halodurans (588 aa), FASTA scores: opt: 363, E():
4.3e-15, (33.15% identity in 356 aa overlap);
Q9PKC7|TC0539 putative N-acetylmuramoyl-L-alanine amidase
from Chlamydia muridarum (268 aa), FASTA scores: opt: 285,
E(): 1.6e-10, (26.05% identity in 242 aa overlap) (RV3915
product appears longer 127 aa); Q9S596|PDCA
penicillin-resistant DD-carboxypeptidase from Myxococcus
xanthus (302 aa), FASTA scores: opt: 270, E():
1.5e-09,(39.85% identity in 158 aa overlap); etc. Note
that previously known as cwlM. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3915"
/db_xref="EnsemblGenomes-Tr:CCP46744"
/db_xref="GOA:L7N653"
/db_xref="InterPro:IPR002477"
/db_xref="InterPro:IPR002508"
/db_xref="InterPro:IPR036365"
/db_xref="InterPro:IPR036366"
/db_xref="UniProtKB/Swiss-Prot:L7N653"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46744.1"
/translation="MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTG
RNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAP
LYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSL
YFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEA
DLLWDLASRLEGRMAAIGMETHLSRPTNRSPSDAERAATANAVGADLMISLRCETQTS
LAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRVHGRTWDLLRLTRMP
TVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLA
HELSVERAGRLGGS"
gene complement(4404433..4405167)
/locus_tag="Rv3916c"
CDS complement(4404433..4405167)
/codon_start=1
/transl_table=11
/locus_tag="Rv3916c"
/product="Conserved hypothetical protein"
/note="Rv3916c, (MTV028.07c), len: 244 aa. Conserved
hypothetical protein, equivalent to
Q50200|ML2705|L222-ORF1 hypothetical protein from
Mycobacterium leprae (259 aa),FASTA scores: opt: 1266,
E(): 2e-74, (76.4% identity in 250 aa overlap). Also
highly similar (but with gaps) to Q9R3S2|STH24.10
hypothetical 22.6 KDA protein from Streptomyces coelicolor
(205 aa), FASTA scores: opt: 387,E(): 7.5e-18, (40.25%
identity in 231 aa overlap). Predicted to be an outer
membrane protein (See Song et al.,2008)."
/db_xref="EnsemblGenomes-Gn:Rv3916c"
/db_xref="EnsemblGenomes-Tr:CCP46745"
/db_xref="GOA:O53594"
/db_xref="UniProtKB/TrEMBL:O53594"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46745.1"
/translation="MSARITALRLEAFEQLPKHARRCVFWEVDPAILGKDDHLADPEF
EKEAWLSMVMLEWGSCGQVATAVPDERSHAEPPCLGYVLYAPPSAVPRAQRFPTAPVS
ADAVLLTSMGIERGQADDDLPHSLIARVIEELVRRGVRALEAFGRTPAATDLQNPGAV
TPDVRPVLEALGDCCVEHCIIDANFLMDVGFVVVAPHPYFPRLRLELDKGLGWKAEVE
AALERLLENARLQEPIAAGSTAGNTS"
gene complement(4405457..4406491)
/gene="parB"
/gene_synonym="parA"
/locus_tag="Rv3917c"
CDS complement(4405457..4406491)
/codon_start=1
/transl_table=11
/gene="parB"
/gene_synonym="parA"
/locus_tag="Rv3917c"
/product="Probable chromosome partitioning protein ParB"
/note="Rv3917c, (MTV028.08c, MT4036), len: 344 aa.
Probable parB, chromosome partitioning protein, equivalent
to Q50201|PARB_MYCLE|ML2706 probable chromosome
partitioning protein from Mycobacterium leprae (333 aa),
FASTA scores: opt: 1654, E(): 1.6e-88, (78.6% identity in
332 aa overlap). Also highly similar to to others e.g.
Q9S6U1|STH24.09 putative partitioning or sporulation
protein from Streptomyces coelicolor (328 aa), FASTA
scores: opt: 966, E(): 9.7e-49, (58.55% identity in 287 aa
overlap) (no similarity on N-terminus);
Q9PB63|PARB_XYLFA|XF2281 probable chromosome partitioning
protein from Xylella fastidiosa (310 aa), FASTA scores:
opt: 598, E(): 1.8e-27, (38.65% identity in 326 aa
overlap); P31857|PARB_PSEPU probable chromosome
partitioning protein from Pseudomonas putida (290
aa),FASTA scores: opt: 573, E(): 4.6e-26, (40.35% identity
in 322 aa overlap); etc. Contains probable
helix-turn-helix motif at aa 179 to 200 (Score 1150, +3.1
0 SD). Belongs to the ParB family. Note that previously
known as parA."
/db_xref="EnsemblGenomes-Gn:Rv3917c"
/db_xref="EnsemblGenomes-Tr:CCP46746"
/db_xref="GOA:P9WIJ9"
/db_xref="InterPro:IPR003115"
/db_xref="InterPro:IPR004437"
/db_xref="InterPro:IPR036086"
/db_xref="InterPro:IPR041468"
/db_xref="UniProtKB/Swiss-Prot:P9WIJ9"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46746.1"
/translation="MTQPSRRKGGLGRGLAALIPTGPADGESGPPTLGPRMGSATADV
VIGGPVPDTSVMGAIYREIPPSAIEANPRQPRQVFDEEALAELVHSIREFGLLQPIVV
RSLAGSQTGVRYQIVMGERRWRAAQEAGLATIPAIVRETGDDNLLRDALLENIHRVQL
NPLEEAAAYQQLLDEFGVTHDELAARIGRSRPLITNMIRLLKLPIPVQRRVAAGVLSA
GHARALLSLEAGPEAQEELASRIVAEGLSVRATEETVTLANHEANRQAHHSDATTPAP
PRRKPIQMPGLQDVAERLSTTFDTRVTVSLGKRKGKIVVEFGSVDDLARIVGLMTTDG
RDKGLHRDAL"
gene complement(4406488..4407531)
/gene="parA"
/gene_synonym="parB"
/locus_tag="Rv3918c"
CDS complement(4406488..4407531)
/codon_start=1
/transl_table=11
/gene="parA"
/gene_synonym="parB"
/locus_tag="Rv3918c"
/product="Probable chromosome partitioning protein ParA"
/note="Rv3918c, (MTV028.09c), len: 347 aa. Probable
parA,chromosome partitioning protein, highly similar to
Q9CCX7|para|ML2707 putative cell division protein from
Mycobacterium leprae (351 aa), FASTA scores: opt:
1679,E(): 2.9e-93, (78.1% identity in 347 aa overlap).
Also highly similar to others e.g. Q9RFM1|para para
protein from Streptomyces coelicolor (357 aa), FASTA
scores: opt: 1197,E(): 2e-64, (60.45% identity in 306 aa
overlap); Q98DZ3|MLL4479|para chromosome partitioning
protein from Rhizobium loti (Mesorhizobium loti) (266 aa),
FASTA scores: opt: 835, E(): 7.2e-43, (50.95% identity in
257 aa overlap); O05189|PARA_CAUCR chromosome partitioning
protein from Caulobacter crescentus (267 aa), FASTA
scores: opt: 813, E(): 1.5e-41, (51.35% identity in 261 aa
overlap) (has its N-terminus shorter); etc. Equivalent to
AAK48403 from Mycobacterium tuberculosis strain CDC1551
(381 aa) but shorter 34 aa. Also similar to other
Mycobacterium tuberculosis proteins: MTCI125.30, FASTA
scores: E(): 4.3e-32, (35.2% identity in 327 aa overlap);
and MTCY07D11.13, FASTA scores: E(): 3e-30, (39.9%
identity in 263 aa overlap). Belongs to the para family.
Possible alternative start site at aa 107. Note that
previously known as parB."
/db_xref="EnsemblGenomes-Gn:Rv3918c"
/db_xref="EnsemblGenomes-Tr:CCP46747"
/db_xref="GOA:Q1LVD4"
/db_xref="InterPro:IPR025669"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:Q1LVD4"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46747.1"
/translation="MSAPWGPVAAGPSALVRSGQASTIEPFQREMTPPTPTPEAAHNP
TMNVSRETSTEFDTPIGAAAERAMRVLHTTHEPLQRPGRRRVLTIANQKGGVGKTTTA
VNIAAALAVQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEMLIGEVSLHTALRRS
PHSERLFCIPATIDLAGAEIELVSMVARENRLRTALAALDNFDFDYVFVDCPPSLGLL
TINALVAAPEVMIPIQCEYYALEGVSQLMRNIEMVKAHLNPQLEVTTVILTMYDGRTK
LADQVADEVRQYFGSKVLRTVIPRSVKVSEAPGYSMTIIDYDPGSRGAMSYLDASREL
AERDRPPSAKGRP"
gene complement(4407528..4408202)
/gene="gid"
/gene_synonym="gidB"
/locus_tag="Rv3919c"
CDS complement(4407528..4408202)
/codon_start=1
/transl_table=11
/gene="gid"
/gene_synonym="gidB"
/locus_tag="Rv3919c"
/product="Probable glucose-inhibited division protein B
Gid"
/note="Rv3919c, (MT4038, MTV028.10c), len: 224 aa.
Probable gid (alternate gene name: gidB),
glucose-inhibited division protein B, equivalent, but
shorter 20 aa, to Q9L7M3 putative GIDB (fragment) from
Mycobacterium paratuberculosis (245 aa), FASTA scores:
opt: 1018, E(): 4.8e-57, (73.95% identity in 211 aa
overlap); and Q50203|GIDB_MYCLE|ML2708 glucose inhibited
division protein B from Mycobacterium leprae (245 aa),
FASTA scores: opt: 966, E(): 9.1e-54, (68.4% identity in
212 aa overlap). Also highly similar to many e.g.
O54571|GIDB_STRCO|STH24.07 from Streptomyces coelicolor
(239 aa), FASTA scores: opt: 654,E(): 3.9e-34, (47.95%
identity in 221 aa overlap); Q9KNG5|VC2774 from Vibrio
cholerae (210 aa), FASTA scores: opt: 300, E(): 6.9e-12,
(38.15% identity in 139 aa overlap);
P17113|GIDB_ECOLI|B3740|Z5240|ECS4682 from Escherichia
coli (several strains) (207 aa), FASTA scores: opt: 287,
E(): 4.5e-11, (34.8% identity in 138 aa overlap); etc.
Contains PS00539 Pyrokinins signature. Belongs to the GIDB
family. Nucleotide position 4407904 in the genome sequence
has been corrected, G:A resulting in S100F."
/db_xref="EnsemblGenomes-Gn:Rv3919c"
/db_xref="EnsemblGenomes-Tr:CCP46748"
/db_xref="GOA:P9WGW9"
/db_xref="InterPro:IPR003682"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:P9WGW9"
/inference="protein motif:PROSITE:PS00539"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46748.1"
/translation="MSPIEPAASAIFGPRLGLARRYAEALAGPGVERGLVGPREVGRL
WDRHLLNCAVIGELLERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLR
EMVTDLGVAVEIVRGRAEESWVQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRML
AIKGERAHDEVREHRRVMIASGAVDVRVVTCGANYLRPPATVVFARRGKQIARGSARM
ASGGTA"
gene complement(4408334..4408897)
/locus_tag="Rv3920c"
CDS complement(4408334..4408897)
/codon_start=1
/transl_table=11
/locus_tag="Rv3920c"
/product="Conserved protein similar to jag protein"
/note="Rv3920c, (MTV028.11c), len: 187 aa. Conserved
protein, similar to jag protein, equivalent to Q9L7M2
hypothetical 20.1 KDA protein from Mycobacterium
paratuberculosis (183 aa), FASTA scores: opt: 1004, E():
7.3e-52, (85.05% identity in 187 aa overlap); and
Q50204|ML2709 hypothetical protein similar to jag protein
SPOIIIJ associated protein in bacillus subtilis from
Mycobacterium leprae (193 aa), FASTA scores: opt: 871,
E(): 4.4e-44, (73.05% identity in 193 aa overlap). Also
similar to other bacterial proteins e.g.
O54595|STH24.06|jag jag-like protein from Streptomyces
coelicolor (170 aa),FASTA scores: opt: 593, E(): 6.7e-28,
(62.85% identity in 167 aa overlap); Q9RCA6|jag|BH4063 jag
protein homolog from Bacillus halodurans (207 aa), FASTA
scores: opt: 282, E(): 1.1e-09, (35.0% identity in 140 aa
overlap); Q9X1H1|TM1460 putative jag protein, putative
from Thermotoga maritima (221 aa), FASTA scores: opt: 258,
E(): 3e-08, (31.9% identity in 138 aa
overlap);Q01620|JAG_BACSU jag protein (SPOIIIJ associated
protein) from Bacillus subtilis (208 aa), FASTA scores:
opt: 196, E(): 0.00012, (28.05% identity in 139 aa
overlap); etc."
/db_xref="EnsemblGenomes-Gn:Rv3920c"
/db_xref="EnsemblGenomes-Tr:CCP46749"
/db_xref="GOA:O53598"
/db_xref="InterPro:IPR001374"
/db_xref="InterPro:IPR015946"
/db_xref="InterPro:IPR034079"
/db_xref="InterPro:IPR036867"
/db_xref="InterPro:IPR038008"
/db_xref="InterPro:IPR039247"
/db_xref="UniProtKB/TrEMBL:O53598"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46749.1"
/translation="MADADTTDFDVDAEAPGGGVREDTATDADEADDQEERLVAEGEI
AGDYLEELLDVLDFDGDIDLDVEGNRAVVSIDGSDDLNKLVGRGGEVLDALQELTRLA
VHQKTGVRSRLMLDIARWRRRRREELAALADEVARRVAETGDREELVPMTPFERKIVH
DAVAAVPGVHSESEGVEPERRVVVLRD"
gene complement(4408969..4410069)
/locus_tag="Rv3921c"
CDS complement(4408969..4410069)
/codon_start=1
/transl_table=11
/locus_tag="Rv3921c"
/product="Probable conserved transmembrane protein"
/note="Rv3921c, (MTV028.12c), len: 366 aa. Probable
conserved transmembrane protein, equivalent to Q9L7M1
hypothetical 39.2 KDA protein from Mycobacterium
paratuberculosis (353 aa), FASTA scores: opt: 2001, E():
8.4e-100, (83.05% identity in 366 aa overlap);
Q9CCX6|ML2710 putative conserved membrane protein from
Mycobacterium leprae (380 aa), FASTA scores: opt:
1929,E(): 6.2e-96, (77.1% identity in 380 aa overlap);
Q50205 CDS 27 on L222 from Mycobacterium leprae (312 aa)
FASTA scores: opt: 1770, E(): 1.6e-87, (88.2% identity in
288 aa overlap). Also similar to other e.g.
O54569|STH24.05 inner membrane protein. from Streptomyces
coelicolor (431 aa),FASTA scores: opt: 412, E(): 6.5e-15,
(33.45% identity in 266 aa overlap); O84253|CT251 60 KDA
inner membrane protein from Chlamydia trachomatis (787
aa), FASTA scores: opt: 304, E(): 6e-09, (27.9% identity
in 269 aa overlap); P29431|60IM_BUCAP 60 KDA
inner-membrane protein homolog from Buchnera aphidicola
(subsp. Schizaphis graminum) (536 aa), FASTA scores: opt:
282, E(): 6.7e-08, (36.1% identity in 108 aa overlap);
etc."
/db_xref="EnsemblGenomes-Gn:Rv3921c"
/db_xref="EnsemblGenomes-Tr:CCP46750"
/db_xref="GOA:P9WIT5"
/db_xref="InterPro:IPR001708"
/db_xref="InterPro:IPR028055"
/db_xref="UniProtKB/Swiss-Prot:P9WIT5"
/experiment="EXISTENCE: identified in proteomics study"
/protein_id="CCP46750.1"
/translation="MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSV
MFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHG
FNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVG
HFLDANLFGAPIGAYMTQRSGLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIAR
QSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGM
IEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDAST
ERPADTSNPARRNSGPSARTPRPGVRPKKRKR"
gene complement(4410053..4410415)
/locus_tag="Rv3922c"
CDS complement(4410053..4410415)
/codon_start=1
/transl_table=11
/locus_tag="Rv3922c"
/product="Possible hemolysin"
/note="Rv3922c, (MTV028.13c), len: 120 aa. Possible
hemolysin, highly similar to Q9L7M0|YIDD_MYCPA
hypothetical 12.4 KDA protein from Mycobacterium
paratuberculosis (115 aa), FASTA scores: opt: 521, E():
1.9e-29, (65.2% identity in 112 aa overlap). Also highly
similar to Q44066|HLYA_AERHY putative alpha-hemolysin from
Aeromonas hydrophila (85 aa), FASTA scores: opt: 276, E():
1.5e-12,(51.45% identity in 70 aa overlap); and to many
bacterial hypothetical proteins from bacterium e.g.
P22847|YIDD_ECOLI|B3704.1 hypothetical protein from
Escherichia coli strain K12 (85 aa), FASTA scores: opt:
276, E(): 1.5e-12, (51.45% identity in 70 aa overlap)."
/db_xref="EnsemblGenomes-Gn:Rv3922c"
/db_xref="EnsemblGenomes-Tr:CCP46751"
/db_xref="GOA:P9WFL9"
/db_xref="InterPro:IPR002696"
/db_xref="UniProtKB/Swiss-Prot:P9WFL9"
/protein_id="CCP46751.1"
/translation="MSLSRQSCGRVVRVTGRASARGLIFVIQVYRHMLSPLRPASCRF
VPTCSQYAVDALTEYGLLRGSWLTMIRLAKCGPWHRGGWDPIPEGLTTGRSCQTDVDG
ANDDWNPASKRGERESFV"
gene complement(4410412..4410789)
/gene="rnpA"
/locus_tag="Rv3923c"
CDS complement(4410412..4410789)
/codon_start=1
/transl_table=11
/gene="rnpA"
/locus_tag="Rv3923c"
/product="Ribonuclease P protein component RnpA (RNaseP
protein) (RNase P protein) (protein C5)"
/note="Rv3923c, (MT4041, MTV028.14c), len: 125 aa.
RnpA,ribonuclease P protein component (see citations
below),equivalent, but longer ~10 aa, to
P46610|RNPA_MYCLE|ML2712 ribonuclease P protein component
from Mycobacterium leprae (120 aa), FASTA scores: opt:
456, E(): 3.3e-24, (63.0% identity in 119 aa overlap); and
Q9L7L9|RNPA from Mycobacterium paratuberculosis (119 aa),
FASTA scores: opt: 426, E(): 3.5e-22, (60.65% identity in
122 aa overlap). Also similar to many e.g.
P25817|RNPA_STRBI from Streptomyces bikiniensis (123 aa),
FASTA scores: opt: 174,E(): 4.2e-05, (36.8% identity in
125 aa overlap); P25814|RNPA_BACSU from Bacillus subtilis
(116 aa) FASTA scores: opt: 168, E(): 0.0001, (26.85%
identity in 108 aa overlap); P48206|RNPA_STRCO|STH24.03
from Streptomyces coelicolor (123 aa), FASTA scores: opt:
166, E(): 0.00015,(37.6% identity in 125 aa overlap); etc.
Contains PS00648 Bacterial Ribonuclease P protein
component signature. Belongs to the RnpA family."
/db_xref="EnsemblGenomes-Gn:Rv3923c"
/db_xref="EnsemblGenomes-Tr:CCP46752"
/db_xref="GOA:P9WGZ3"
/db_xref="InterPro:IPR000100"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020539"
/db_xref="InterPro:IPR020568"
/db_xref="UniProtKB/Swiss-Prot:P9WGZ3"
/inference="protein motif:PROSITE:PS00648"
/protein_id="CCP46752.1"
/translation="MIATPGLFAVLRARNRMRRSADFETTVKHGMRTVRSDMVVYWWR
GSGGGPRVGLIIAKSVGSAVERHRVARRLRHVAGSIVKELHPSDHVVIRALPSSRHVS
SARLEQQLRCGLRRAVELAGSDR"
gene complement(4410786..4410929)
/gene="rpmH"
/locus_tag="Rv3924c"
CDS complement(4410786..4410929)
/codon_start=1
/transl_table=11
/gene="rpmH"
/locus_tag="Rv3924c"
/product="50S ribosomal protein L34 RpmH"
/note="Rv3924c, (MTV028.15), len: 47 aa. rpmH, 50s
ribosomal protein l34 (see citations below), equivalent to
many mycobacterial 50S ribosomal protein L34 e.g.
P46386|RL34_MYCLE|RPMH|ML2713 from Mycobacterium leprae
(47 aa), FASTA scores: opt: 287, E(): 8.5e-17, (91.5%
identity in 47 aa overlap); and Q9L7L8|RL34_MYCPA|RPMH
from Mycobacterium paratuberculosis (47 aa), FASTA scores:
opt: 281, E(): 2.6e-16, (89.35% identity in 47 aa
overlap). Also highly similar to other ribosomal proteins
e.g. P27901|RL34_STRCO|RPMH|STH24.02 from Streptomyces
coelicolor (45 aa), FASTA scores: opt: 234, E():
1.4e-12,(79.05% identity in 43 aa overlap); and
P05647|RL34_BACSU|RPMH from Bacillus subtilis (44 aa)
FASTA scores: opt: 229, E(): 3.7e-12, (72.35% identity in
47 aa overlap); etc. Contains PS00784 Ribosomal protein
L34 signature. Belongs to the L34P family of ribosomal
proteins."
/db_xref="EnsemblGenomes-Gn:Rv3924c"
/db_xref="EnsemblGenomes-Tr:CCP46753"
/db_xref="GOA:P9WH93"
/db_xref="InterPro:IPR000271"
/db_xref="InterPro:IPR020939"
/db_xref="PDB:5V7Q"
/db_xref="UniProtKB/Swiss-Prot:P9WH93"
/inference="protein motif:PROSITE:PS00784"
/protein_id="CCP46753.1"
/translation="MTKGKRTFQPNNRRRARVHGFRLRMRTRAGRSIVSSRRRKGRRT
LSA"
BASE COUNT 758552 a 1449998 c 1444614 g 758368 t
ORIGIN
1 ttgaccgatg accccggttc aggcttcacc acagtgtgga acgcggtcgt ctccgaactt
61 aacggcgacc ctaaggttga cgacggaccc agcagtgatg ctaatctcag cgctccgctg
121 acccctcagc aaagggcttg gctcaatctc gtccagccat tgaccatcgt cgaggggttt
181 gctctgttat ccgtgccgag cagctttgtc caaaacgaaa tcgagcgcca tctgcgggcc
241 ccgattaccg acgctctcag ccgccgactc ggacatcaga tccaactcgg ggtccgcatc
301 gctccgccgg cgaccgacga agccgacgac actaccgtgc cgccttccga aaatcctgct
361 accacatcgc cagacaccac aaccgacaac gacgagattg atgacagcgc tgcggcacgg
421 ggcgataacc agcacagttg gccaagttac ttcaccgagc gcccgcacaa taccgattcc
481 gctaccgctg gcgtaaccag ccttaaccgt cgctacacct ttgatacgtt cgttatcggc
541 gcctccaacc ggttcgcgca cgccgccgcc ttggcgatcg cagaagcacc cgcccgcgct
601 tacaaccccc tgttcatctg gggcgagtcc ggtctcggca agacacacct gctacacgcg
661 gcaggcaact atgcccaacg gttgttcccg ggaatgcggg tcaaatatgt ctccaccgag
721 gaattcacca acgacttcat taactcgctc cgcgatgacc gcaaggtcgc attcaaacgc
781 agctaccgcg acgtagacgt gctgttggtc gacgacatcc aattcattga aggcaaagag
841 ggtattcaag aggagttctt ccacaccttc aacaccttgc acaatgccaa caagcaaatc
901 gtcatctcat ctgaccgccc acccaagcag ctcgccaccc tcgaggaccg gctgagaacc
961 cgctttgagt gggggctgat cactgacgta caaccacccg agctggagac ccgcatcgcc
1021 atcttgcgca agaaagcaca gatggaacgg ctcgcggtcc ccgacgatgt cctcgaactc
1081 atcgccagca gtatcgaacg caatatccgt gaactcgagg gcgcgctgat ccgggtcacc
1141 gcgttcgcct cattgaacaa aacaccaatc gacaaagcgc tggccgagat tgtgcttcgc
1201 gatctgatcg ccgacgccaa caccatgcaa atcagcgcgg cgacgatcat ggctgccacc
1261 gccgaatact tcgacactac cgtcgaagag cttcgcgggc ccggcaagac ccgagcactg
1321 gcccagtcac gacagattgc gatgtacctg tgtcgtgagc tcaccgatct ttcgttgccc
1381 aaaatcggcc aagcgttcgg ccgtgatcac acaaccgtca tgtacgccca acgcaagatc
1441 ctgtccgaga tggccgagcg ccgtgaggtc tttgatcacg tcaaagaact caccactcgc
1501 atccgtcagc gctccaagcg ctagcacggc gtgttcttcc gacaacgttc ttaaaaaaac
1561 ttctctctcc caggtcacac cagtcacaga gattggctgt gagtgtcgct gtgcacaaac
1621 cgcgcacaga ctcatacagt cccggcggtt ccgttcacaa cccacgcctc atccccaccg
1681 acccaacaca caccccacag tcatcgccac cgtcatccac aactccgacc gacgtcgacc
1741 tgcaccaaga ccagactgtc cccaaactgc acaccctcta atactgttac cgagatttct
1801 tcgtcgtttg ttcttggaaa gacagcgctg gggatcgttc gctggatacc acccgcataa
1861 ctggctcgtc gcggtgggtc agaggtcaat gatgaacttt caagttgacg tgagaagctc
1921 tacggttgtt gttcgactgc tgttgcggcc gtcgtggcgg gtcacgcgtc atgggcattc
1981 gtcgttggca gtccccacgc tagcggggcg ctagccacgg gatcgaactc atcgtgaggt
2041 gaaagggcgc aatggacgcg gctacgacaa gagttggcct caccgacttg acgtttcgtt
2101 tgctacgaga gtctttcgcc gatgcggtgt cgtgggtggc taaaaatctg ccagccaggc
2161 ccgcggtgcc ggtgctctcc ggcgtgttgt tgaccggctc ggacaacggt ctgacgattt
2221 ccggattcga ctacgaggtt tccgccgagg cccaggttgg cgctgaaatt gtttctcctg
2281 gaagcgtttt agtttctggc cgattgttgt ccgatattac ccgggcgttg cctaacaagc
2341 ccgtagacgt tcatgtcgaa ggtaaccggg tcgcattgac ctgcggtaac gccaggtttt
2401 cgctaccgac gatgccagtc gaggattatc cgacgctgcc gacgctgccg gaagagaccg
2461 gattgttgcc tgcggaatta ttcgccgagg caatcagtca ggtcgctatc gccgccggcc
2521 gggacgacac gttgcctatg ttgaccggca tccgggtcga aatcctcggt gagacggtgg
2581 ttttggccgc taccgacagg tttcgcctgg ctgttcgaga actgaagtgg tcggcgtcgt
2641 cgccagatat cgaagcggct gtgctggtcc cggccaagac gctggccgag gccgccaaag
2701 cgggcatcgg cggctctgac gttcgtttgt cgttgggtac tgggccgggg gtgggcaagg
2761 atggcctgct cggtatcagt gggaacggca agcgcagcac cacgcgactt cttgatgccg
2821 agttcccgaa gtttcggcag ttgctaccaa ccgaacacac cgcggtggcc accatggacg
2881 tggccgagtt gatcgaagcg atcaagctgg ttgcgttggt agctgatcgg ggcgcgcagg
2941 tgcgcatgga gttcgctgat ggcagcgtgc ggctttctgc gggtgccgat gatgttggac
3001 gagccgagga agatcttgtt gttgactatg ccggtgaacc attgacgatt gcgtttaacc
3061 caacctatct aacggacggt ttgagttcgt tgcgctcgga gcgagtgtct ttcgggttta
3121 cgactgcggg taagcctgcc ttgctacgtc cggtgtccgg ggacgatcgc cctgtggcgg
3181 gtctgaatgg caacggtccg ttcccggcgg tgtcgacgga ctatgtctat ctgttgatgc
3241 cggttcggtt gccgggctga gcacttggcg cccgggtagg tgtacgtccg tcatttgggg
3301 ctgcgtgact tccggtcctg ggcatgtgta gatctggaat tgcatccagg gcggacggtt
3361 tttgttgggc ctaacggtta tggtaagacg aatcttattg aggcactgtg gtattcgacg
3421 acgttaggtt cgcaccgcgt tagcgccgat ttgccgttga tccgggtagg taccgatcgt
3481 gcggtgatct ccacgatcgt ggtgaacgac ggtagagaat gtgccgtcga cctcgagatc
3541 gccacggggc gagtcaacaa agcgcgattg aatcgatcat cggtccgaag tacacgtgat
3601 gtggtcggag tgcttcgagc tgtgttgttt gcccctgagg atctggggtt ggttcgtggg
3661 gatcccgctg accggcggcg ctatctggat gatctggcga tcgtgcgtag gcctgcgatc
3721 gctgcggtac gagccgaata tgagagggtg ttgcgccagc ggacggcgtt attgaagtcc
3781 gtacctggag cacggtatcg gggtgaccgg ggtgtgtttg acactcttga ggtatgggac
3841 agtcgtttgg cggagcacgg ggctgaactg gtggccgccc gcatcgattt ggtcaaccag
3901 ttggcaccgg aagtgaagaa ggcataccag ctgttggcgc cggaatcgcg atcggcgtct
3961 atcggttatc gggccagcat ggatgtaacc ggtcccagcg agcagtcaga tatcgatcgg
4021 caattgttag cagctcggct gttggcggcg ctggcggccc gtcgggatgc cgaactcgag
4081 cgtggggttt gtctagttgg tccgcaccgt gacgacctaa tactgcgact aggcgatcaa
4141 cccgcgaaag gatttgctag ccatggggag gcgtggtcgt tggcggtggc actgcggttg
4201 gcggcctatc aactgttacg cgttgatggt ggtgagccgg tgttgttgct cgacgacgtg
4261 ttcgccgaac tggatgtcat gcgccgtcga gcgttggcga cggcggccga gtccgccgaa
4321 caggtgttgg tgactgccgc ggtgctcgag gatattcccg ccggctggga cgccaggcgg
4381 gtgcacatcg atgtgcgtgc cgatgacacc ggatcgatgt cggtggttct gccatgacgg
4441 gttctgttga ccggcccgac cagaatcgcg gtgagcgatc aatgaagtca ccagggttgg
4501 atttggtcag gcgcaccctg gacgaagctc gtgctgctgc ccgcgcgcgc ggacaagacg
4561 ccggtcgagg gcgggtcgct tccgttgcgt cgggtcgggt ggccggacgg cgacgaagct
4621 ggtcgggtcc ggggcccgac attcgtgatc cacaaccgct gggtaaggcc gctcgtgagc
4681 tggcaaagaa acgcggctgg tcggtgcggg tcgccgaggg tatggtgctc ggccagtggt
4741 ctgcggtggt cggccaccag atcgccgaac atgcacgccc gactgcgcta aacgacgggg
4801 tgttgagcgt gattgcggag tcgacggcgt gggcgacgca gttgaggatc atgcaggccc
4861 agcttctggc caagatcgcc gcagcggttg gcaacgatgt ggtgcgatcg ctaaagatca
4921 ccgggccggc ggcaccatcg tggcgcaagg ggcctcgcca tattgccggt aggggtccgc
4981 gcgacaccta cggataacac gtcgatcggc ccagaacaag gcgctccggt cccggcctga
5041 gagcctcgag gacgaagcgg atccgtatgc cggacgtcgg gacgcaccag gaagaaagat
5101 gtccgacgca cggcgcggtt agatgggtaa aaacgaggcc agaagatcgg ccctggcgcc
5161 cgatcacggt acagtggtgt gcgaccccct gcggcgactc aaccgcatgc acgcaacccc
5221 tgaggagagt attcggatcg tggctgccca gaaaaagaag gcccaagacg aatacggcgc
5281 tgcgtctatc accattctcg aagggctgga ggccgtccgc aaacgtcccg gcatgtacat
5341 tggctcgacc ggtgagcgcg gtttacacca tctcatttgg gaggtggtcg acaacgcggt
5401 cgacgaggcg atggccggtt atgcaaccac agtgaacgta gtgctgcttg aggatggcgg
5461 tgtcgaggtc gccgacgacg gccgcggcat tccggtcgcc acccacgcct ccggcatacc
5521 gaccgtcgac gtggtgatga cacaactaca tgccggcggc aagttcgact cggacgcgta
5581 tgcgatatct ggtggtctgc acggcgtcgg cgtgtcggtg gttaacgcgc tatccacccg
5641 gctcgaagtc gagatcaagc gcgacgggta cgagtggtct caggtttatg agaagtcgga
5701 acccctgggc ctcaagcaag gggcgccgac caagaagacg gggtcaacgg tgcggttctg
5761 ggccgacccc gctgttttcg aaaccacgga atacgacttc gaaaccgtcg cccgccggct
5821 gcaagagatg gcgttcctca acaaggggct gaccatcaac ctgaccgacg agagggtgac
5881 ccaagacgag gtcgtcgacg aagtggtcag cgacgtcgcc gaggcgccga agtcggcaag
5941 tgaacgcgca gccgaatcca ctgcaccgca caaagttaag agccgcacct ttcactatcc
6001 gggtggcctg gtggacttcg tgaaacacat caaccgcacc aagaacgcga ttcatagcag
6061 catcgtggac ttttccggca agggcaccgg gcacgaggtg gagatcgcga tgcaatggaa
6121 cgccgggtat tcggagtcgg tgcacacctt cgccaacacc atcaacaccc acgagggcgg
6181 cacccacgaa gagggcttcc gcagcgcgct gacgtcggtg gtgaacaagt acgccaagga
6241 ccgcaagcta ctgaaggaca aggaccccaa cctcaccggt gacgatatcc gggaaggcct
6301 ggccgctgtg atctcggtga aggtcagcga accgcagttc gagggccaga ccaagaccaa
6361 gttgggcaac accgaggtca aatcgtttgt gcagaaggtc tgtaacgaac agctgaccca
6421 ctggtttgaa gccaacccca ccgacgcgaa agtcgttgtg aacaaggctg tgtcctcggc
6481 gcaagcccgt atcgcggcac gtaaggcacg agagttggtg cggcgtaaga gcgccaccga
6541 catcggtgga ttgcccggca agctggccga ttgccgttcc acggatccgc gcaagtccga
6601 actgtatgtc gtagaaggtg actcggccgg cggttctgca aaaagcggtc gcgattcgat
6661 gttccaggcg atacttccgc tgcgcggcaa gatcatcaat gtggagaaag cgcgcatcga
6721 ccgggtgcta aagaacaccg aagttcaggc gatcatcacg gcgctgggca ccgggatcca
6781 cgacgagttc gatatcggca agctgcgcta ccacaagatc gtgctgatgg ccgacgccga
6841 tgttgacggc caacatattt ccacgctgtt gttgacgttg ttgttccggt tcatgcggcc
6901 gctcatcgag aacgggcatg tgtttttggc acaaccgccg ctgtacaaac tcaagtggca
6961 gcgcagtgac ccggaattcg catactccga ccgcgagcgc gacggtctgc tggaggcggg
7021 gctgaaggcc gggaagaaga tcaacaagga agacggcatt cagcggtaca agggtctagg
7081 tgaaatggac gctaaggagt tgtgggagac caccatggat ccctcggttc gtgtgttgcg
7141 tcaagtgacg ctggacgacg ccgccgccgc cgacgagttg ttctccatcc tgatgggcga
7201 ggacgtcgac gcgcggcgca gctttatcac ccgcaacgcc aaggatgttc ggttcctgga
7261 tgtctaacgc aaccctgcgt tcgattgcaa acgaggaata gatgacagac acgacgttgc
7321 cgcctgacga ctcgctcgac cggatcgaac cggttgacat cgagcaggag atgcagcgca
7381 gctacatcga ctatgcgatg agcgtgatcg tcggccgcgc gctgccggag gtgcgcgacg
7441 ggctcaagcc cgtgcatcgc cgggtgctct atgcaatgtt cgattccggc ttccgcccgg
7501 accgcagcca cgccaagtcg gcccggtcgg ttgccgagac catgggcaac taccacccgc
7561 acggcgacgc gtcgatctac gacagcctgg tgcgcatggc ccagccctgg tcgctgcgct
7621 acccgctggt ggacggccag ggcaacttcg gctcgccagg caatgaccca ccggcggcga
7681 tgaggtacac cgaagcccgg ctgaccccgt tggcgatgga gatgctgagg gaaatcgacg
7741 aggagacagt cgatttcatc cctaactacg acggccgggt gcaagagccg acggtgctac
7801 ccagccggtt ccccaacctg ctggccaacg ggtcaggcgg catcgcggtc ggcatggcaa
7861 ccaatatccc gccgcacaac ctgcgtgagc tggccgacgc ggtgttctgg gcgctggaga
7921 atcacgacgc cgacgaagag gagaccctgg ccgcggtcat ggggcgggtt aaaggcccgg
7981 acttcccgac cgccggactg atcgtcggat cccagggcac cgctgatgcc tacaaaactg
8041 gccgcggctc cattcgaatg cgcggagttg ttgaggtaga agaggattcc cgcggtcgta
8101 cctcgctggt gatcaccgag ttgccgtatc aggtcaacca cgacaacttc atcacttcga
8161 tcgccgaaca ggtccgagac ggcaagctgg ccggcatttc caacattgag gaccagtcta
8221 gcgatcgggt cggtttacgc atcgtcatcg agatcaagcg cgatgcggtg gccaaggtgg
8281 tgatcaataa cctttacaag cacacccagc tgcagaccag ctttggcgcc aacatgctag
8341 cgatcgtcga cggggtgccg cgcacgctgc ggctggacca gctgatccgc tattacgttg
8401 accaccaact cgacgtcatt gtgcggcgca ccacctaccg gctgcgcaag gcaaacgagc
8461 gagcccacat tctgcgcggc ctggttaaag cgctcgacgc gctggacgag gtcattgcac
8521 tgatccgggc gtcggagacc gtcgatatcg cccgggccgg actgatcgag ctgctcgaca
8581 tcgacgagat ccaggcccag gcaatcctgg acatgcagtt gcggcgcctg gccgcactgg
8641 aacgccagcg catcatcgac gacctggcca aaatcgaggc cgagatcgcc gatctggaag
8701 acatcctggc aaaacccgag cggcagcgtg ggatcgtgcg cgacgaactc gccgaaatcg
8761 tggacaggca cggcgacgac cggcgtaccc ggatcatcgc ggccgacgga gacgtcagcg
8821 acgaggattt gatcgcccgc gaggacgtcg ttgtcactat caccgaaacg ggatacgcca
8881 agcgcaccaa gaccgatctg tatcgcagcc agaaacgcgg cggcaagggc gtgcagggtg
8941 cggggttgaa gcaggacgac atcgtcgcgc acttcttcgt gtgctccacc cacgatttga
9001 tcctgttctt caccacccag ggacgggttt atcgggccaa ggcctacgac ttgcccgagg
9061 cctcccggac ggcgcgcggg cagcacgtgg ccaacctgtt agccttccag cccgaggaac
9121 gcatcgccca ggtcatccag attcgcggct acaccgacgc cccgtacctg gtgctggcca
9181 ctcgcaacgg gctggtgaaa aagtccaagc tgaccgactt cgactccaat cgctcgggcg
9241 gaatcgtggc ggtcaacctg cgcgacaacg acgagctggt cggtgcggtg ctgtgttcgg
9301 ccggcgacga cctgctgctg gtctcggcca acgggcagtc catcaggttc tcggcgaccg
9361 acgaggcgct gcggccaatg ggtcgtgcca cctcgggtgt gcagggcatg cggttcaata
9421 tcgacgaccg gctgctgtcg ctgaacgtcg tgcgtgaagg cacctatctg ctggtggcga
9481 cgtcaggggg ctatgcgaaa cgtaccgcga tcgaggaata cccggtacag ggccgcggcg
9541 gtaaaggtgt gctgacggtc atgtacgacc gccggcgcgg caggttggtt ggggcgttga
9601 ttgtcgacga cgacagcgag ctgtatgccg tcacttccgg cggtggcgtg atccgcaccg
9661 cggcacgcca ggttcgcaag gcgggacggc agaccaaggg tgttcggttg atgaatctgg
9721 gcgagggcga cacactgttg gccatcgcgc gcaacgccga agaaagtggc gacgataatg
9781 ccgtggacgc caacggcgca gaccagacgg gcaattaatc aggctcgccc gacgacgatg
9841 cggatcgcgt agcgatctga ggaggaatcg ggcagctagg ctcggcagcc gggtacgagt
9901 gttaggagtc ggggtgactg caccgaacga gccgggggcg ctcagcaagg gcgacggccc
9961 gaatgcggat ggcttggtcg accgtggggg cgcacatcgg gcagcgaccg ggccaggccg
10021 cataccagat gctggagacc cgccgccgtg gcagcgtgct gcgactcggc aatcccaagc
10081 ggggcatcgt cagccgccgc cggtatcaca ccctgagggg cgcccgacca acccgcccgc
10141 cgccgccgat gctcggctga atcgcttcat ctccggtgcg tctgccccgg tgaccggccc
10201 agccgccgcg gtcaggaccc cgcagccgga tcccgacgct tcgctggggt gtggcgacgg
10261 ttcccccgcc gaggcctatg ccagcgagct gcccgaccta tccggcccga ctccgcgggc
10321 cccgcaacgc aaccccgcgc cggcgcgtcc cgcggagggt ggcgcgggat cgagagggga
10381 ttcggccgcc ggttcgagcg gcggtcgttc gattaccgct gagagtagag acgcccgtgt
10441 ccagctgtcg gcgcggcgaa gccgcgggcc ggttcgagcc agcatgcaga tccgacggat
10501 tgatccatgg agcacgttga aggtgtcgct gttgttgtcg gtggcgctgt tcttcgtctg
10561 gatgatcacg gtcgcgttcc tctacctggt gctcggcggt atgggcgtat gggccaagct
10621 caacagcaac gtcggtgacc tgttgaacaa cgcgagcggc agcagcgcgg aacttgtctc
10681 cagcggcacc atcttcggcg gcgcattcct gatcggcttg gtcaacatcg tcctgatgac
10741 cgcgcttgcc accatcggtg cgttcgtcta caacctgatc accgatctga tcggcggcat
10801 cgaagtgacg ctggcagacc gggactaatg ttttgagagt cgggcgccgg ttgcggtaat
10861 ctcgtcgctc ggccgtacgc gagtacgggc ctatagctca ggcggttaga gcgcttcgct
10921 gataacgaag aggtcggagg ttcgagtcct cctaggccca cgaccatgtg cccgtcacga
10981 cgttcggtga ggttcgcatt gccactggcc gcgatcgctg tggcggccat cgtcgtgcgg
11041 ttccgacgcg gagccgatgt ctggcatgtg gccggcgatc cacctcctga tcacataacc
11101 ggtgacgaag aggggcctta gctcagttgg tagagcactg cctttgcaag gcaggggtca
11161 ggggttcgag tcccctaggc tccacaagtg aaaagcgtag ctcggatact tcgaatgacc
11221 acgtttgatc acaatcgcga gtgaagaggg cgttgatggc cactccgacg gcctcgacac
11281 ccgacccgta caggtggcgg tagcggtcca aggtcaaccc ggcggagtcg tgttcgagca
11341 tgttctgaag tgccttgaat tcgccccggc ctggatcgcc aacgacgccg ggtgtgccga
11401 gctcatgcag ttttgaactc ctacaccacc gccggcttcc cggtagcgtc catcacagtc
11461 tgagggaaca gctgcgccgc ggtcaccgcc tgcgaccacc accggcgccg cacatggctg
11521 ccgcgcatgt agccgcccgc cgagtccggg aacgctagaa gctcagcaac ccatcgaacg
11581 cggtcggccg gttgtcggcg tccacgagca cgcaccctag agcgaaagtc atggatccgc
11641 cgttggcggg gtctccggta ttgccggact cgtctatgta agcgaccagc acgcgacgat
11701 gctggcacga ttcttgggcg attgaccaca gttacagata actactgtta accgcagttg
11761 tgtcctttcg caggtggact gagttgtaac ccattgatct gcatcatgat tcgcctgtgc
11821 aaggcggggg tcaggggttc gaatccctag gccccaccgt gtgacgaccg gcctcaggag
11881 cgcggttgca cctcgacgct cggtggtcgg ggcgacggct ccggtcgcga cgagcgccgg
11941 acgatgctga aggcgacggc accgccggcg aggatggccg ccgcgatccc cgcgaagatc
12001 cagaggtggt gtttgctgcg acgttgggtc cgggcgtcct gtagggcctg cggtaggttg
12061 gccaccacgt cctgggcagc ggtcagctct tgagcgagcg tctcttgggc ggcagcgacc
12121 tcgcgggcca atcggccttc ccggtaacgg cggcgaagcc cggccgcggt cgaccgggcg
12181 gactgaagcc caagtccgac cccgagttcg aggaggcctc gggtcacgtc caccggaccc
12241 accgcagagt aggccagacc ccgggtcagc cgctcgcgtg gggtcaaccg ggtttccacc
12301 tgctcactca ttttgccgcc tttctgtgtc cgggccgagg cttgcgctca ataactcggt
12361 caagttcctt cacagactgc catcactggc ccgtcggcgg gctcgttgcg ggtgcgccgc
12421 gtgcgggttt gtgttccggg caccgggtgg gggcccgccc gggcgtaatg gcagactgtg
12481 attccgtgac taacagcccc cttgcgaccg ctaccgccac gctgcacact aaccgcggcg
12541 acatcaagat cgccctgttc ggaaaccatg cgcccaagac cgtcgccaat tttgtgggcc
12601 ttgcgcaggg caccaaggac tattcgaccc aaaacgcatc aggtggcccg tccggcccgt
12661 tctacgacgg cgcggtcttt caccgggtga tccagggctt catgatccag ggtggcgatc
12721 caaccgggac gggtcgcggc ggacccggct acaagttcgc cgacgagttc caccccgagc
12781 tgcaattcga caagccctat ctgctcgcga tggccaacgc cggtccgggc accaacggct
12841 cacagttttt catcaccgtc ggcaagactc cgcacctgaa ccggcgccac accattttcg
12901 gtgaagtgat cgacgcggag tcacagcggg ttgtggaggc gatctccaag acggccaccg
12961 acggcaacga tcggccgacg gacccggtgg tgatcgagtc gatcaccatc tcctgacccg
13021 aagctacgtc ggctcgtcgc tcgaatacac cttgtggacc cgccagggca cgtggcggta
13081 caccgacacg ccgttggggc cgttcaaccg gacgccctca cgccaagtcc gctcaccttt
13141 ggccgcgacc ggcgtaaccg gcagcggtaa gcgcatcgag cacctccact gggtcggtgc
13201 cgagatccca gcgggacaaa atcagcagcc ccccgctgac cgtttcgatc tcgagcaggc
13261 gcaccaggcg gccgtaacgg cgaaactcgt cgattcggat gatcttgata ttggaatgtc
13321 gtaatagctg cgtccggaac caacctcgga tcgccaggcc gtcgggggta attgccagcc
13381 ttggacgtgc gcgccaagtg gcgctcgcaa acaagatcag acccagcgcg gcaactccgg
13441 tcaacacccg cccgggcgta tctgtgacta aggtcacaga cgcaatagcc atcacgactc
13501 ccccggctcc gcaaccagcg attcccgagg tgcgaggcgc ccatgctgtt tgctgcatgt
13561 attccttaga ccctctcacc actgcagaca aagttatcca cagacgctat caacagtggg
13621 gatgaatcac atgcgtgtga ttgagtgacc aaaaggttgc tggcacagta acgacccgac
13681 cagaatatga attcattcta tcggcggcgt ggatcaatgc cagcgcatcg tgagcaacaa
13741 accggtgatc atgaaagcga acgcgatcgc atagttccag ggaccgagtt gcgccatcca
13801 attgagcgct gtgggggctt ggctgccaat ggctgccaac tgaaacacca ttaaccagat
13861 gagtccgatc agcatcagac cgatgaacaa cgagacgaac catacgctcg acggtccgac
13921 cttcaccttc atcggcgtgc ggctcaccgc gctgacggtg aagtcgttct tcttgcggac
13981 cttggacttg ggcatcactt tcctcgggat ctggcgggac tacctcgaca agacgacgaa
14041 tggcccgggg tgcaacgata gaagttgcag ctgcaggcat accttgttat gagactaacc
14101 cacccaacac cctgcccgga aaacggagag accatgattg atcggcgccg atcggcgtgg
14161 cgtttcagtg tccccttagt gtgcttgctg gcggggctgc tgctggccgc cacgcatggg
14221 gtgtcgggcg gcaccgagat ccgccgcagc gatgcgccgc gactggtcga ccttgtccgt
14281 cgggcgcagg catcggtgaa ccgtctcgcc accgaacgcg aagcgctgac caccagaatc
14341 gactcggtgc acggccgatc tgtcgatacc gcgttggcgg ccatgcagcg gcggtccgcc
14401 aagctggccg gtgtggcggc tatgaatccg gtccatgggc cgggcctggt ggttaccctg
14461 caagacgcgc aacgcgacgc caacggccgg tttccgcgcg acgcgtcccc ggacgatctg
14521 gttgtgcatc agcaagacat cgaggctgtc ctcaacgcgt tgtggaatgc cggtgctgag
14581 gcgatccaga tgcaggacca gcgcatcatc gcgatgtcga tagctcgttg tgtcggaaac
14641 acgttgctgc tcaacgggcg tacctatagc ccgccctaca cgatcgccgc gatcggagac
14701 gccgccgcca tgcaggctgc tctggctgcg gctcccctgg tgacgctcta caagcagtac
14761 gtggtccggt tcggcctcgg gtactgcgaa gaagtccatc ctgacttgca gatagtcggc
14821 tatgccgatc ccgtccggat gcacttcgcg cagcctgcag gccccttgga ctactgaacg
14881 actgccggca gggtcaggcg gtagcctgtc acgatgcgga tcctggtcgt tgacaactac
14941 gacagcttcg tgttcaacct ggtgcagtac ctcggccagc tcggcatcga ggccgaggtg
15001 tggcgcaacg acgaccaccg gctatccgat gaggccgccg tcgccggcca attcgacggt
15061 gtcctgctca gtcccggtcc gggtaccccg gagcgcgcgg gcgcgtcggt gagtatcgtg
15121 cacgcgtgtg cggcagcaca cacccctttg ctgggggtct gccttgggca ccaagccatc
15181 ggcgttgcgt tcggcgccac cgtggaccgt gcgcccgagc tattgcacgg caagaccagc
15241 agcgtattcc acaccaatgt cggtgtgcta caagggcttc cggatccctt cacggccact
15301 cgataccatt cgttgacaat tctgcctaag tcgctgccag cggtgctgag ggtcacggcc
15361 cgcactagca gcggtgtgat catggccgtg cagcacaccg ggctgccgat ccacggtgtc
15421 cagttccatc cggagtcgat tctcaccgag ggcgggcacc gcatactggc caactggctc
15481 acctgctgcg gatggacgca agacgacacc ctggtacgtc ggctggaaaa cgaagtgctc
15541 accgccatct caccgcactt cccaacttca accgctagcg cgggcgaagc tactggccga
15601 acctcagcgt gatgatgccg tcccggttga cgccggtccc cgccggcggg ttttgataga
15661 cgacccggtt gtgttgggag ccaccggcgt cgacgtcggc ccctttgtcg agcatcccgg
15721 tccagcccag cgcgcgcaat cgtggttcgg cgtcgaccca gaacatgccg gataggtcgg
15781 gcatgacgaa ttggttgccc ttggacacct gtagttcgat gactgaatcg accggaactg
15841 tggtgcctgc gggtggattg gtgccggtca cctcgccggc gggacggggg ctgtccaccg
15901 aggcctgact gaatttggtg aagccgtaga cgttgaggtt cttctgcgcc acgtcgacgg
15961 tctggcccgc gacatcggga atgtctttgg tcgccggacc agagccaacg atgatgatga
16021 ccacattggt gatggccgac gtctggttgg ctggcgggtt ggtcccgatg accttgccca
16081 ccagttccgg ggtggacggc gaattcgctt gcttgaagcg gccgaatccg gcggcagtca
16141 gtttcttgac cgcttcggcg tatgtcagcg tggagacgtc gggtatttcg cgttgctcgg
16201 gtccggtgga cacgttgact gtgatctcgt cgcctgcact caccgacgtg ttggcggccg
16261 ggtcggtgcc gataacgtgg tccggtggga ttgtcgagtc cggcttctgc aaggtgcgga
16321 ttttgaagcc ccggttttgc agtgtggcga tggcgtcggc ggaggattga ccccgaacgt
16381 cgggaacttg aacgtcgcgg gtgatgccgc cgaacgtgtt gatggcgatg gttaccacga
16441 cggtcagcac agcgagcacg gcgaccaccg caacccaacg gcccaccgaa ccgatgctgc
16501 ggtcacggtc ggtgtcgtct aagtcctggc gtggtagcgg atcggtgcgc ggaccgctaa
16561 ggttgccggc cgcagacgac agcagcgagg tccgctcggc atcggtgagc actttgggcg
16621 cctcgggcgg ctcaccgttg tgcacgcgga ccaggtcggc gcgcatctcc gccgctgtct
16681 gatagcggtt ttccggattt ttggccagcg ccttgagaac gacggcgtcc aggtcggcgg
16741 agaggccttc gtgccgcgcc gaaggtggga tcgggtcttc gcgcacatgt tggtaggcaa
16801 ccgagacggg tgagtcgccg gtgaaaggtg gctccccggt gaggacttca taaagaacac
16861 agcccaagga atagacatcg gatcgggcgt cgacggaatc accccgggcc tgttcgggtg
16921 acaggtactg cgccgtgccg atcactgctg cggtctgggt cacgctgttg ccgctgtcgg
16981 caatggcgcg ggcgatgccg aaatccatca cctttactgc attggtcgcg ctgatcatga
17041 tgttcgccgg cttgacgtca cggtggatga ttccgttctg atgactgaag ttcagcgctt
17101 ggcaggcgtc ggcgatgacc tcgatggcgc gtttgggcgt catcggccct tcggtgtgga
17161 caatgtcgcg cagggtaacg ccgtcgacgt attccatgac gatgtagggc aatggcccgg
17221 cgggcgtttc ggcttcaccg gtgtcgtaga ccgcgacgat tgcagggtgg ttcaatgccg
17281 cggcgttttg cgcctcacgc cggaagcgaa ggtaaaaact gggatcgcgg gctagatcag
17341 cgcgcagcac cttgaccgca acgtcgcggt gcaaccggag gtcgcgggcc aggtggacct
17401 cggacatgcc cccaaatcca aggatttcgc caagttcgta gcggtcggac aggtgggaag
17461 gggtggtcat tgcgctatct cgtatcgggc cagcgacgcg cgcgaatgcg gtgtcggcgg
17521 gacaacccag ctttgcagtc cagaatgacg tgtttccccg cgttccgtcc aattgagtcg
17581 cgggctagca tcagtcccgc cagtgttgct ggccggaggg ttcccggtgg tggtcacggt
17641 cggcgtcggt gcctgctgcg ggctgttgtc cccgggcgct ttgatgacga gcagcacggc
17701 gatgatgatt gccagcgccc ccagcacccc cgcggcccag agcagcgcac gctgaccgga
17761 cgaaaacgtg cgccgcggcg gccggtgacc acccgtggcc gggcgggatc gacgggatgc
17821 cgcagtccgg ccagcagagt tggccgcgac cctggctgtc gtacccgacg gaatggccgc
17881 cggggcggcc cggccagggg ggggtgtctg gctgggccgc gggggccggc ggccggcgcg
17941 caccgctgcc accgcgtcgg cgaacggtcc cccactgcga tagcgcatcg cggggttctt
18001 caccagagtt atctcgatga gttctcgcac attgggcggc aggtcgggag gcagcggcgg
18061 cggcggctcc ttgatgtgct tcattgccac ggtcagggca ccatcgccgg cgaacggccg
18121 tttacccgaa accgcttcat acccaacaac tcccagtgaa tagacgtcgc tggccgggct
18181 ggcgtcgtga ccgagggcct gctccggcgc gatgtattgg gcggtgccca tcaccatgcc
18241 ggtctgggtc acgggcgctg catcgacggc tttggcgatg ccgaagtcgg tgatcttcac
18301 ctgcccggtg ggggtgatca agatgttgcc cggtttgacg tcgcggtgca ccaggccagc
18361 ggcatgcgcg atctgcagag cgcggccggt ctgctcgagc atgtccagtg cgtgccgcaa
18421 cgacagccgg ccggtgcgtt tgagcaccga atttagtggc tcgccgttga ccagctccat
18481 caccaggtag gccgtgcgac cctccccgtt catctggctt tcgccgtagt cgtgcacgct
18541 ggcgatgccc ggatggttca gcatcgcggt ggtgcgcgct tcggcccgga accgttcgat
18601 gaactccgga tcggaggaga actcgctctt gagcaccttc accgcaacac gccggcccaa
18661 ccggttatcc acggcctccc agacttggcc cataccaccg gtggcgatga ggcgctgcag
18721 gcggtatctg cccgacagcg tcacgccaac tcgggggctc atggttcccc ctgcagtgcg
18781 gcttcgatca ccgcccgccc gatcggtgcc gcgagggcac ctccggtggc ggacagccga
18841 tcagccccgt tctccaccag cacggcaaca gccaccttgg gcgcttgtgc gggcgcaaag
18901 gcgatgtacc aagcgtgcgg tggagtgtga cgagggtcgg tgccatgttc ggcggtgccc
18961 gtcttggatg cgatctgcac gccggggatt gcccctttct gctgtgcgac tttctcggcg
19021 ccgaccatca gctctgttag cttagcggcg acctgcggtg acaccgcgcg gcgctgctgg
19081 tatccgacgg tggttgagat attggctagg tccggtccct tgaggctgcc gactagataa
19141 ggcctcatcg taatgccgcc gtttgcgatg gtcgcggcta tttctgcgtt cgctagcggg
19201 gtcagcgcaa cgtccttttg gccgatactg gtcatcccta gtgcggcgct gtccgggata
19261 ggcccgacgg ttgattccgc cacttgcagc ggagttgggc gcggtgggct atcgagaccg
19321 aacgcgcgcg ccatgctgcg cagggcgtcg gcgccggtgc ggatgcccag ctggacgaat
19381 gcggtgttgc atgatttgac gaatgcctca cgcagcgaca cggtgggttc gtccccgcac
19441 ggcgcaccgc cgtagttctc tagctgggcg gtgctgcctg gcaacggaat tgtgggcgcc
19501 gcagtcagct gttcggtctc ggtggccccg gcggccagcg cggccgcagt ggtgatcact
19561 ttgaaagtcg aacccggtgg atacgtctca gagatggcac ggttggtcag tggagaggcg
19621 ggattgtcgc caagccgctg ccaggcttgc gcctgcacct cggggttatg cgacgccagc
19681 aggttggggt cgtaggacgg agaagacacc aacgccaaaa tcttgccggt tgatggctca
19741 agggcgacca ccgctccctt acagggcccg tagcagcctt gctgcatcgc gtcccagccg
19801 gcttgctgaa tgcgcgggtt gatcgtggta tcgacattac cgccgcgtgg gtcgcgaccg
19861 gtgaagaagt cggccagccg gcggccgaac agacggcggt cggacccgtt caatatcggg
19921 tcctcggctc gttctagggc ggtgctggaa tagcgcaggg agtagaagcc ggtaaccggc
19981 gcgtacacct caggattggg atagacccgc aggaaacgaa agcggccgtc ggtggctacc
20041 gagtacgcca gcagttggcc accagcggtg atctggccgc gctgccgtga atactcgtcg
20101 agcaacactc gctggttgcg gggatcggca cgcagcccgt cggcggtgaa gacctgcgtc
20161 atggtcgcgt tgagcagtag caacacgatc aacgccatca cggtcaccga tattcggcgc
20221 agagaggcgt tcatacgcgt tcgatgacct cggtgccggc cgccgtaatc ggcgacttat
20281 ttcgtgggcg ggtgcgcagt gggcggcggg ctccgtgcga gatgcgtgcc aggatggcca
20341 gcaatatgta gttggccagc agtgaagacc cgccgtagga catccacggt gtggtcaacc
20401 cggtcagcgg aatgagtcgg gtcacaccgc cgacgacgat gaacagctga atggctagcg
20461 tcgatgagag gccggcggcc agcagcttgc cgaagctatc gcgggtggcg atggccgtgc
20521 gcaaaccccg gatgatcacg atggtgtaga gcatcaggat ggccgtcaag cccaccaacc
20581 caagctcttc gccgaacgcg gcgatgatga aatcggtgga tgccgcgggc acggtgtcgg
20641 gttgaccatt accgagcccg gtgccgaaga taccgcctgt agcgaagctg aaaagcgact
20701 gcacgatctg atatccggtg ccgtctggat ctgcgaacgg atccagccag gtctgtacgc
20761 ggagccggac gtgctcaaaa atgaagtacg ccaccaaggt tcctgccgcg aacagagtca
20821 ggccgatgac gacccaactg aaccgctggg tggcgaggta aaccaccacc agaaacgatg
20881 tgtacagcag cagcgaagcg ccgaggtctt tctcgaagac catcacaccc accgagatga
20941 cccaggctgc caacagtggc gcgaggtctc gcgggcgcgg cagggtcatt ccgagcaaat
21001 gtttgccggc gctggtgaac aggccgcgtt tggccaccag taccgccgaa aagaagatca
21061 gcagcagaat ctttgaaaat tcggcgggtt gaatcgagaa gccgggcaac cggatccaga
21121 tcttggcgcc gttctgttcg gacagtgctg ccgggagcag cgcgggaact gccaagaaaa
21181 ccagacccgc gagcccgcaa atgtagccgt agcgtgcgag ctgtcggtgg tccttgagga
21241 aggtcaccac gagcgcgaag gcagctacgc ccaccagcgt ccacagcatc tgctggtttg
21301 cgctggggtg ccgatgctcg ccgatctcgt tgtccaccag atcgaggcgg tggatcatta
21361 ccaggccaag tccgttgagc agtgccacca ccgggagcaa cagcgggtca gtgtaggggg
21421 cgaagcgccg gatggccaga tgcgcggatc cgaacagggt caggaaggcc agtccgtagc
21481 tagtcaagtc ccagggcacc ccctggtctt gattggcctg cacgaccagc agtgcggcaa
21541 acgtgattac ggcggcaaag cacagcagca gcagttcagc gttgcgccga gtcggcaacg
21601 ggggcgttac ggccaccggc gcttgcagtc gtgtcgtcat gccgccgccc ggcagtcgat
21661 gcccggctga ggcgggggtg gcggaagtgc ggccatcgtc ggcgagctgg tgacgggcca
21721 aggcgtcggc ggcgacgcgg gcgctgccgg ggaggcactc gtggggatgg caggagtagt
21781 tccggtgggg gccggcgcgg aggtggtggg tgatggagag gctggcgagg aggtgacgtt
21841 tggttcggtt gtctcgctgg tggtgggtgg ggccgggcgc ccgggcgggg acgtggcacg
21901 cggcgccggg caaggcggca gcagggagtt ggccgccagt tcgcgcaact gcccgatggc
21961 gtcatcgaga gtgccggccg ggagaccggc ccgaacctgt gcgcgctccg gcggtcgcag
22021 atcctccagt ttcatcagat ggcagtcgag agggccccca gactgtccgt agctgatctg
22081 cgacagctcg ttacgcgggc tgaggcagcc catcaggtaa ggctggtgca gggacatgcc
22141 cagtagcgac ccttgaatcc cccgcatgat ggacacgctg ccggcgtagt ccgctacgta
22201 gtagttgctg cggatgatcg cgcgaccaat gagcaggccc gcagtcatca gcacggtcac
22261 cagtgcgaca acgaatgcta gccgtcggcc cgaccaccgt ggccgactga atgtatcggc
22321 ctgtggcgga acgcgtttaa cgatctcctt gcgctggctg atggcagagg cccggccggc
22381 ggcggtgttg ggcagggtca gttggtcgtc gtcgcctgag accgccccgg ccagaatcgg
22441 ttgggtctgg ccgtagtcgt agtcgacgac gtcggcgacg acgacagtga cgttgtcggg
22501 gccgccgccg cgcagcgcca gttcaatgag gcggtgagcg ctctcggcaa cctcggggat
22561 ctgcagggcc tcgaggatag tttcatcgct aaccggatcg gacaacccgt ccgagcacag
22621 caggtaacga tcaccggcgc gggcttctcg catggtcagc gtcggttcga cctcatggcc
22681 ggtcaacgcc cgcatgatca acgagcgttg cgggtggctg tgcgcctcct ccggggtgat
22741 ccggccttcg tcgaccagcg tttggacaaa cgtgtcgtcc ttggtgatct gcgtcagctc
22801 accgtcgcgc agcaggtaac cgcgcgagtc accgatatgc accaggccga gccggttgcc
22861 cgcgaacagg attgcggtga gcgtggtacc catgccttcg agatcgggct ccatctcgac
22921 ttgcgctgcg atagccgagt tgccggcgcg caccgcggca tccagcttgg ccagcagatc
22981 gccaccgggc tcgtcgtcat cgagatgggc caatgcggca atcaccaact gggacgccac
23041 ctcgccggcc gcatgcccac ccatgccgtc ggccagggcc aatagccgtg ccccagcgta
23101 gaccgagtct tcgttgttgg cgcgtaccaa gccgcgatcg ctgcgcgccg cgtatcgcag
23161 gaccagggtc acgcgcgcca ctctcccccg caagcgggtg ggggtacccc ccacttgtgg
23221 gggcgcgccc ccaccgcttc tctgcgctct gcatcgtcgc cagcgcgggt cacgggcgca
23281 actcgattgc agttttgccg atgcgaaccg gcgttccgat cggaactcgt accgcagtcg
23341 tcaccttcgc cctgtccagg taagtgccgt tggtcgatcc tagatcttcg acgtaccact
23401 cggagccgcg catagacagc cgagcgtgcc gcgtcgaggc gtagtcgtcg gtcagcacca
23461 gggtcgagtc gtcggcgcgc ccgatcaaca ccggctgttc gctcagcgtg atacgcgcgc
23521 cagtcaacgc accttcggtc accaccaggt agcgtgcagc gtgccggcgc tgacgcgcgc
23581 ctaagagcgt ccctcgcagc gccaggccgc ggcgcatcat gaccgcgccg gtcggcgcat
23641 aaatgtcggt cttcaagatc cgtagcacgg accagatgaa tacccacaac aacatcaaga
23701 atccggcacg cgtcagttgc agtaccaacc cctgcatctg gcgtcctttc cgtcctgcac
23761 cgtctgctcc ggccccgcgc tgccgagcac gtcagcaaag tcacgatact ttgacggtgg
23821 tcggcgcggg tcaaccccgg cagcttcgag cccagtaggt tcagtgcatg cggacgatga
23881 tctcggagtg tcccaagcgg atcacatcac cgtcggccaa ctgccactcc tgtaccggtg
23941 cattgttaac agtggtgccg ttggtggagt tcaggtctgc gagcaatgcg acctgcccgt
24001 cccaccggat ctccaagtga cggcgtgaca caccggtgtc gggcagccgg aactgggcgt
24061 cctgtccgcg accgatgatg ttggagccct cgcggagctg gtaagtgcgt ccgctgccgt
24121 cgtcgagctg cagcgtaacc gacgttccgg cggacccata gccgccctgc ccgtaaccgc
24181 tgtagccacc gggcgctggc tgaccgtagt ccggagcgcc tgattggccg tagtcgtagt
24241 ctcggccggc gggttcggcg tacccgccac cctgaggagc gtatcccggg acccgcgggg
24301 attcggtgta gcgggtgtag tcagcgccgc cgccatagtc ttgccggccg tatgtcgtgg
24361 cgccttgctg gtagccctgg tcgtaaccgc cttggtcggg gtaagccggt cgttgctcgg
24421 gcgggcccgg agggccagag ggcacatagc tgccctcctc gtggcgagcc gggccacgcc
24481 cgtactcccc gtacccgccg tagccgggct ggccgccacc gggtgaaggg ccgtagccgc
24541 cgctttggcg atagccctgg tcgtagccgg gagcgccgta gccggcagcc gggccgggag
24601 aaacaggagg gcgttgctcg tagggcggcg gatagccccc ctgcccttgg tcggggtagc
24661 ctcgaccctg gtcctggtac ccgcgctggt cggggtagcc gcgttgctcg gggtaaccgc
24721 gttgctcggg gtaaccgccc tggtcggggt acccgatttg ctcggggtag tcgccctggt
24781 ccgggtggcg cgggcgtggg tagcccggct ggggcgggta gccgcccgtc tcgggtggat
24841 accccccgcg ggggtcagat ccgccttgcg gatccgggcc accacgcgga tcctcttgcg
24901 gacgcgcata gcggtcgtcg taatactcgt cgggacgccc ctgcccctga ccgccacggt
24961 agctcgaatt gtcactcatt ggtgctactc ctggttctgc gccaaacgcg tggtttgatt
25021 gtggccgggc gcaatcgatg accggcgggt gggtctcaac gtcggggtta acagtgccgc
25081 gggcgcggaa ctggccggta tgcaggttcg acgactgctc gaatcggacg accacatcac
25141 catacgtttg ccacccctgt tcttggatat agtccgccaa gtcccgagca aaaccggttg
25201 acttcagctc aggatcagcg cccaacttct caaagtcgtg cacaccgagg gtaatgatgt
25261 attcgttggg cgccaaaagg cgatttccct gcagcgactg gatgccgtcg gccgcctcgc
25321 ggcgcagcag ggcttcgacc tcttgcggga cgatcgagcc tccaaagatg cgggcaaacg
25381 catcgccaac cgtctgctcg agtttgcgct caacgcgctg aaccagcctt ttctggctac
25441 ccatctttca gcgctcgcct cactgttctg gtgcatcgtc ggcgcaaggc aaacgactcg
25501 cctgtatgtc gtgtcaatca atcatggtat cgggacagtg tgagcgagcg gaaagggccg
25561 gccacgccca ctgagcccgc cggcgcccct ggcagcggat ggggcctgcg gctactacag
25621 tggtatggtc ctccggttgt tgcgggcgag tggcggaatg gcagacgcgc tggcttcagg
25681 tgccagtgtc cttcgggacg tgggggttca agtccccctt cgcccaccgt actgtgagac
25741 gagtcgtgac cgacatcgtc gtcgaaacgg ccgccatggg cgtggttgga acggctagcg
25801 cacgcccacg gccagcccag ggcaaccccg gtatcgacgt gactatcgcc ggcgctgtcc
25861 ggttcagctc ggtcgcggcc gcagccgggt ggcggggcgc ctcggtaccc ttttacacgg
25921 cgcgcatcgc ggtcagcgtc ctcgccgctt gttgcgccat accggttatc acgtcggcgg
25981 ctggcaggac ggcattgacc aggcccgcgg cttgaccggc ggtgacattg gcgatgctgt
26041 agtcacgcgc agcaacggct cgccaatatc tggccatggc ttcttcgcga tggagaatgt
26101 cgagttcggt gtcctcgaat tggtcggtga gggcgttgct tagcacgctc atcgtgtgtc
26161 cttgcggcca gggatagcgc cgtagctgat cgtagatagt ggtgcggcac atgtcgtcgc
26221 cagtggccgc cagcagcggg tcccgcgcct gcggtgtgga taacgcttcg accgtggcgt
26281 agaagcgcgt accgaccaat accccggcgg cgcccaacat caacgcggcg gcaaggcccc
26341 ggccgtcggc gatgcccccg gcggcgatca ccgggatatc agttccccgc gcggtgacca
26401 ggtcgacgat ttcgggtacc aaggtcaggg tggaacgtgg accgtggccg tgcccaccgg
26461 cctcggtgcc ctgagccacc aacacatcgg cgccgacctg cagggctcgc tcggcctggg
26521 tccggttttg gatctggcag accaaccgcg ttccggcgga cttgatggcg tcagcgaaaa
26581 ccgcggggtc cccgaacgac agcatcaccg ccaccggctc atactgcagc gcgaggtcga
26641 gcagctgcgg ttggcgggcc aaagaccagg tgatgaaccc gcagcccacc ggcgctccag
26701 cggcgagatc gaactgccgg gccaaccaat cccggtcccc atagccgccc ccgatgaggc
26761 cgagtccccc tgcgccactt accgcggcag ccagctcacc gccggcgatc aagtccattg
26821 gcgcggacac tatcggatag tcgattccga acatctggct aaaggccgtc gatagcacca
26881 caacaacctc cttggcgagc gtcgtgatga cacgcagatc ctggccgatg gtaggtgatc
26941 aggcgagcca cttcttcgcc gaactcgcga gccgagcctg atcacgctgg gtttggcaac
27001 tgccgggctt gccgaccggg catcaagcgg ccggttgtgg gccaacctgt gcgatcggca
27061 ggtgcaccac gaccccgggc accggggtga cctcgagtcc ttcgttgcgg gccagcagag
27121 ccgcattgtc cgggagctgc ctggaattga tctcgccgcc ggcaatccga cgcagcacgt
27181 cgtgggctgc cgcgagctgt tcgcgctttc ggtactggcc gccgggaagc ttgatgccgg
27241 cccatacgcc gtactccacc cgatgctcga ccgcgtgttg agcacaccgg cgctgctgta
27301 ggagcgggca ccggcgcagg cattggatcc gcgcttgggt ggccgaccgc tcataggcgc
27361 gtgccttagc ggcgccgtcg ctgccgtcgt catcggggta cccgaaccat agttccgggt
27421 cggttgcgca ggggtgtgcc atgtgccggc ctccttgttg aacgaaacat aggcaaaagc
27481 gtatatgtct gtggcgggct ctgcaagaga atcgcgataa aaacgtatat acataagggg
27541 tggccgcggc cgagtcgtat ccgggtagta tccggcttat ggccggagcg tgcggtgagc
27601 cgtgagtcgg ccggcgcggc cattcgcgca cttcgcgagt cgcgtgactg gtccctcgcg
27661 gacctggcgg ccgccactgg cgtaagcacc atgggcctga gctatctgga gcgcggtgcc
27721 cgcaagccac acaaaagcac agttcagaag gtcgaaaatg gcctcggcct gccgcctggc
27781 acctactcgc ggctgttggt cgccgctgat cccgatgcgg agctggcccg actgatcgcc
27841 gcacagccgt ccaacccgac ggctgtccgc cgcgccggtg cggtcgtcgt ggaccgccac
27901 agcgataccg acgtgctgga gggctacgcc gaagcacagc tcgatgccat caaatccgtc
27961 atcgaccgat tgcctgcgac gacctccaac gaatatgaga cgtatattct ctctgtgatc
28021 gcgcaatgcg tgaaggcgga gatgctggcc gccagctcct ggcgggtggc ggtgaacgcc
28081 ggcgccgact cgaccggccg gctcatggag catctgcggg cgctggaagc cacgcgcggc
28141 gcgctactgg agcggatgcc gacaagcttg agcgcccggt tcgatcgggc atgtgcgcag
28201 tcgtcgttac cggaggcggt cgtggccgcg ctaatcggcg tcggcgccga cgaaatgtgg
28261 gatatccgca atcggggcgt catccctgcg ggcgcgctcc cccgcgtccg agccttcgtc
28321 gacgcaatcg aggcaagtca cgacgcggat gaggggcagc agtgaattac agcgaggtcg
28381 agctgttgag tcgcgctcat caactgttcg ccggagacag tcggcgaccg gggttggatg
28441 cgggcaccac accctacggg gatctgctgt ctcgggctgc cgacctgaat gtgggtgcgg
28501 gccagcgccg gtatcaactc gccgtggacc acagccgggc ggccttgctg tctgctgcgc
28561 gaaccgatgc cgcggccggg gccgtcatca ccggcgctca acgggatcgg gcatgggccc
28621 ggcggtcgac cggaaccgtt ctcgacgagg ctcgctcgga taccaccgtt actgcggtta
28681 tgccgatagc ccagcgcgaa gccatacgcc gtcgtgtggc gcggctgcgc gcgcaacgag
28741 cccatgtgct gacggcgcga cgacgggcac gacggcacct ggcggcgctg cgtgcgctgc
28801 ggtaccgggt ggcgcacggc ccgggggtcg cgctggccaa acttcggctg ccgtcgccga
28861 gcggtcgcgc cggcatcgcg gtccacgccg cgctgtcgcg acttggccgt ccctatgtct
28921 ggggcgcaac ggggcccaac cagttcgact gttccggttt ggtccagtgg gcctacgccc
28981 aggcgggtgt tcacctggat cgcaccacct atcaacagat caacgagggg atcccggtgc
29041 cgcgctcaca ggtccggccg ggcgatctgg tcttcccgca ccccgggcac gtgcagctgg
29101 cgatcggcaa caatctggtc gtcgaggcgc cccatgcggg cgcgtcggtt cgggtcagct
29161 cgctgggcaa caacgtgcag attcggcgac cgctgagtgg cagataatcg cccaatcaga
29221 cgggcaggat gagaaggttg aaccatgtcg gagcaagccg ggtcttcggt agctgtcatc
29281 caggagcgcc aggctttgct ggcaaggcaa cacgacgccg tggccgaagc cgaccgtgag
29341 ttggccgacg tgctagccag cgcgcatgcg gccatgcggg aaagcgtccg tcggctggat
29401 gctatcgcgg ccgaactcga ccgcgcggtt ccggatcagg atcagcttgc cgtcgatacg
29461 cccatgggag cgcgtgagtt tcaaacgttc ctggtcgcca agcagcgcga gatcgtagcg
29521 gtcgtcgccg ccgcccacga gctcgatcgc gcaaaaagcg ctgtgctaaa gcgcctgcgg
29581 gcacagtaca cggaaccggc ccgttagctg cggaccggat acgctggacc ggcaggcgtt
29641 gggtgaattg tcggcgacta cacacctagg tactgtcacg cggcatggaa gcgccgggga
29701 cagggcccgc agtgggtcgc agtggcgttt gacgcggcga tgtccacgca cgaagatctc
29761 cttgccacga tcaggtacgt ccgcgaccga accggtgacc caaacgcgtg gcagaccggg
29821 ttgacaccga ccgaggtgac cgcggtggtc acgtccacga cacgttccga acagctcgat
29881 gccattttgc gtaagatccg ccagcggcat tcgaacctgt actatccagc accgcccgat
29941 cgggaacaag gagacgccgc ccgtgccatc gcggatgcgg aagcagctct ggcacatcag
30001 aattcggcta ccgcgcagct cgatctgcag gtcgtctcgg caattctgaa cgcgcatctg
30061 aagactgtcg agggtggcga atcgctgcac gagcttcagc aagagatcga agccgcggta
30121 cgcattcgat ccgatctgga cactccggcc ggcgcgcgtg atttccagcg tttcttgatc
30181 ggcaagctca aggatatccg ggaggtggtt gcgaccgcga gcctggacgc tgcgtcgaaa
30241 tccgctctga tggccgcctg gacatcgctg tatgacgcat ccaagggcga ccgtggcgat
30301 gccgatgacc gcggaccggc gtcggtcggc tcgggcggcg cgcccgcacg cggtgccggt
30361 cagcagccgg agttgccgac acgagccgaa cccgattgcc tcctcgactc gctgctgctc
30421 gaggatccgg gtttgctggc cgatgaccta caggtgccgg gaggcacatc cgcggcaata
30481 ccatcagcgt cgtcgacgcc aagcctgccc aatcttggcg gagcaacgat gccgggtggc
30541 ggagcaacac cggccttggt ccccggtgtg agcgcgccgg gtgggcttcc gctctccggc
30601 ctgctgcgcg gcgtgggtga cgaaccggag ttgacggact tcgacgaacg gggacaagaa
30661 gtcagggatc cggccgatta tgagcattcc aacgaaccgg atgagcgtcg cgccgacgac
30721 cgagaaggcg ccgacgagga cgccgggctg ggcaagtcag aatcgccacc gcaggctccg
30781 acgaccgtga cgctgcccaa cggtgagacg gtgaccgcgg ccagtcccca gctcgccgcg
30841 gcgatcaagg cggcggccag cggcacaccg atcgcagatg cgttccaaca acagggaatt
30901 gccatcccgc taccgggaac cgcggtcgcc aaccccgtcg accccgcccg gatctcagcg
30961 ggagacgtag gtgtgttcac cgccacgccc ttgcccttgg ccctagcaaa gctcttctgg
31021 acggccagat tcaacacatc tcagccgtgc gagggccaaa ctttctaggc tggatacatc
31081 cagcggcgac cgcgaccgcg ccggcgagga ccgaagcacc gacaccaacc aggccggcgg
31141 ccgctcgata ggtactgacc gcccggtcac aacaagagga gacagcggat gacagatcga
31201 attcacgtgc agcctgcaca tttacgtcag gccgctgccc atcaccagca gaccgccgac
31261 tacctgcgga ccgtgccgtc gtcgcacgac gcgatccgcg aaagtctgga ctcgctgggg
31321 cctattttca gtgagctccg cgacaccggg cgtgagctgc tcgagctcag aaagcagtgc
31381 taccagcagc aagccgacaa ccacgccgat attgcccaga acctgcgaac gtcggccgcg
31441 atgtgggagc agcacgagcg agcggcgtcg cgcagcctcg gcaacatcat tgacgggagc
31501 cgatgacagg gcgatgaccg acgccaatcc cgctttcgac acggtccacc ccagcgggca
31561 cattcttgtt cggtcctgcc gcggtggata catgcatagc gtctcgctga gcgaggcggc
31621 gatggagacc gacgcagaaa ccctggcgga agccatcctg ctcaccgccg acgtgtcctg
31681 ccttaaagcg ttgctggaag tacgcaacga gatcgtggcg gcgggccaca ccccgtccgc
31741 gcaggttccc acgaccgacg acctgaacgt cgcgatcgaa aagctgctgg cccatcaact
31801 gcgccgccgt aaccgttgaa gtgctagatg agccaggtct tggtgctgtc gggatcgggt
31861 gcgatgtcgg tgggcggctc gatcggattg gggccgaaca attctcgcgc tcgagtgagc
31921 agagcccgca cctcgtcgag ttgctgctgc agcgcagaat cagccataac cccacgctac
31981 ccaggccccg tctgacacac aattcaccac ccgctcaccg cctgcgcggg ccagatgatg
32041 ccggtacgct tacccggtgg cgatcttcgg tcgatggagt gcgcgccagc gactccggag
32101 agcgacccgg gaatccctca cgattccgac gtttagctcc tcgctggatt gcaccacacg
32161 ggtaattggc gggctctggc ccgctgagct ttcgtctaac accgccgaaa ccgccacgct
32221 tgcagaacat ctgaaagcgg atctgcatcg gatagttggt tctgccaacg acgagctgat
32281 ggtcatctgg cgtgcgggga tggctgattc gacgcgacgc gcagaagaag acagagtgat
32341 cgaccgcgcc cgcgcgtcgg cgatgcgtcg cgtcgagtcg gcgatgcgcg agcttcggca
32401 gataacgggg cgcgttcccg tggaaattcc gcgtatgcgc ggcgccggcg gctcggatct
32461 ggacacgaca cgactcatgc cggccgtcac ggtagttcag cccgctgacc aggcctgtac
32521 ggattggccg gttgccgccg ccgaggatga cgaagcccga ctgcagcgcc tcctggcgtt
32581 cgtggctcgt caggagccac ggctgaactg ggcggtcggc gttcacgcgg acggcacgac
32641 ggtcctggtc accgacgtcg cccatggttg gatacctccg ggcatcgccc ttcccgaagg
32701 cgtgcgattg ttggcaccgg cgcgacgcgc cggcagagcc cccgagttgg tcggtatcac
32761 gacgtgttgc aagacgtaca cccccggtga ctcgctgcgt cgggcggtcg attcaaccgc
32821 gccgacgtcc tcggtgcagc cgcgagcgtt gccagcgatc gccggcctga gtgtggagct
32881 gggcatagcg acccagcggc acgacggctt accgaagatc gtgcacgcca tggccacggc
32941 ggccggcaac ggcgccgccg ccgaggaagt cgacctgttg cgggtgcacg tcgataccgc
33001 gctccaccac gtcttggccc agtatccccg ggtcgatccg gcgttactgc tcaactgtat
33061 gttgttggcc gccaccgagc gcagcgtcac gggagacccg atcgcggcga actatcactt
33121 cgcgtggttc cgggaactcg attcacgccg atagctttct cgaatcccca cggcaagcgt
33181 ccggcgatga attgacgctg gtggggggcg tggacatact gtcatggtgt cggggtcgga
33241 cagtcgcagc gaaccgagcc agctgagcga ccgagacctc gtcgaatcgg ttcttcgtga
33301 cttgagcgag gcggccgaca agtgggaggc gctcgtcacg caggctgaaa ctgttaccta
33361 cagcgtggac ttgggagacg ttcgcgctgt tgccaattcg gacgggcggt tgctcgagct
33421 gacgttgcat ccgggcgtga tgaccggcta cgcgcacggg gagctggccg accgagtgaa
33481 cctggcgatt acggccctgc gcgacgaggt tgaggccgag aaccgggcac ggtacggcgg
33541 ccgcctgcag tgacatcggt atctgcgagg atcaagccca tttgctggca aggcatttcg
33601 gcgcggggcg caaggcccac agccgggccg tggccaccct gaaagccgat atccaagcct
33661 ggcacccggc tggcatccag accccgaagc cgcgatgcga atcagatgtg ttcgcgcgaa
33721 tcggtcacac gagccaccca tcaactcgga agagccgggt ggggccggga gcatccgagg
33781 caccgcttgc ctgacataac agcgtaaccg ccccgccatt gtcgctgtga tggacatgcc
33841 ccagccattt gtcggctagc tatacagcga acgtcaattt ttcgtgaatc agcctgaggc
33901 tattgataat tcacggcggc acgtcctact cttagcggcg ctatgcgacc caatgcgcgt
33961 gcgatgttgc gtttggtgca ttgtggtgcc ggtgctggtg ggccggcgat aacgtcgaaa
34021 ggtgcggtat tgggtgaccg tgttggcgcg ttgtcgcagt gccgatcggc ggcagcgctg
34081 agtcgattcg actttgcacc ccgtgactct gttcccaccg ccaccttcgg tggtggatgc
34141 gctttcaggt ccaccaatag gctagctgtt ttcgagcggt gtatttgcgt ggggggtgaa
34201 tgtggatacg gacaatgaca ggcccacgct ggcgagggtt taccgcagcc tgcgggacat
34261 ttgtccggac agctggaatc ttccgggcgg tcggatgccc actggcttgg gctatgactt
34321 tctgcgccct gtcgaggact cggggatcaa cgacctgaag cactattact tcatggcgga
34381 tttggccgat gggcaaccgc taggccgggc aaacctctat agcgtctgtt tcgacctggc
34441 caccaccgac cgcaagctca ctccggcctg gcgaacgacc atcaaacggt ggtttccggg
34501 gtttatgacc ttccgtttcc tcgagtgcgg gttgctcacc atggtgagca acccgctggc
34561 gttgcggtcc gacaccgact tggagcgggt attgcctgtg ctggccggcc agatggacca
34621 gttggcgcat gacgacgggt cggatttctt gatgatccgg gacgtggacc cggaacacta
34681 ccagcgatac cttgacatcc tgcgcccgtt gggctttcgg cctgcgctgg gcttttcccg
34741 ggtagacacg accatcagct ggtcgagcgt ggaagaggca ctgggctgcc tgtctcacaa
34801 aaggcgcctg ccgttgaaga cgtcgctgga gtttcgtgag cggttcggta tcgaggtcga
34861 ggaactcgac gagtatgccg agcatgcgcc ggtattggcc cggctttggc gcaacgtcaa
34921 gacggaggca aaggattacc agcgcgagga cctgaaccct gagttcttcg cggcgtgttc
34981 tcggcatctg catggacgta gcagactgtg gttgttccgc taccagggca cgccaattgc
35041 cttctttttg aacgtttggg gtgcggatga gaactacata ctgcttgagt ggggcatcga
35101 tcgtgatttt gaacattata ggaaggcgaa tctgtaccgg gcggcgctga tgctcagcct
35161 aaaagatgcg atcagccgag ataaacggcg aatggaaatg ggtattacga actatttcac
35221 aaaacttcgc attccgggtg cccgagtcat accgaccatc tatttcctgc gtcacagcac
35281 ggatccggtg catacggcaa cgttagcgcg aatgatgatg cacaatattc aacggccaac
35341 gctacccgac gatatgtcgg aggaattctg tcgctgggaa gagcgaatac gtctggacca
35401 ggacgggcta cccgaacacg atatctttcg caagatcgat cgtcagcaca aatacacggg
35461 gctcaaactc ggcggagtct acggttttta tccccgattc accggaccgc agcgatccac
35521 ggtcaaggcc gcggagctgg gcgagatcgt gttgctgggc acgaactcgt atctgggcct
35581 ggccacccat ccagaggtgg tggaggcctc ggcggaggcc acgcgacggt acggcaccgg
35641 ctgctcgggt tcgccgttgc tgaacggcac gttggacttg cacgtctcgc ttgagcagga
35701 actagcctgt tttttgggca aacccgccgc cgtgttgtgc tccaccggat atcagagcaa
35761 cctggcggcg atcagcgcgc tatgcgaatc cggggacatg atcatccaag acgcgctgaa
35821 ccaccgcagc ctgttcgacg ccgccaggtt gtccggggcc gacttcacct tgtaccggca
35881 caacgacatg gaccacctgg cgcgggtgct acgccgcacc gaggggcgcc gccggatcat
35941 cgtcgtggac gcggtgttca gcatggaagg caccgtcgcc gacctggcca ccatcgccga
36001 gcttgccgac cggcacggct gccgggtcta tgtggacgag tcccatgcgc tgggcgtgct
36061 cggccccgac gggcgaggag cttcggccgc gttgggtgtc ttggcgcgca tggacgtggt
36121 gatgggcacg ttcagcaaat cctttgcctc cgtcggcggg ttcatcgccg gagatcggcc
36181 cgtcgtggac tacatccggc acaacggttc aggtcatgtg ttttccgcca gcctgccgcc
36241 ggccgccgcg gctgccaccc acgcggctct gcgcgtcagt cggcgtgaac ccgaccggcg
36301 ggctcgggtg ctggccgcgg ccgagtacat ggccaccggc ctggcacggc agggctatca
36361 ggccgagtat cacggaaccg cgatcgtgcc ggtgatcctg ggcaacccga ccgtggcgca
36421 tgcgggctat ctgcggctga tgcgctccgg ggtgtatgtg aacccggtgg cccccccagc
36481 cgtgccggag gagcgttcgg gattccgcac cagctaccta gccgaccacc gacaatctga
36541 cctcgaccgg gccttgcacg tgtttgccgg ccttgccgag gacctgaccc cgcaaggagc
36601 cgcgctatga aagaggccat caacgccacc atccaacgga tcttgcgaac cgaccgcggc
36661 atcaccgcga accaggtact cgtcgacgac ctgggttttg actcgctcaa gctgttccag
36721 ttgatcaccg agctagaaga cgaattcgac atcgccatct ctttccgcga cgcacagaac
36781 atcaaaacag tgggagacgt ctacaccagc gtcgcggtct ggttccccga aaccgccaag
36841 ccggccccac ttgggaaagg aacagcatga ccgacgacgc cgatcttgat ctggtccgaa
36901 gaactttcgc cgcgtttgcc cgcggcgacc tcgccgagct gacgcaatgc tttgcgcccg
36961 acgtggagca gtttgtcccg ggcaagcacg ccctggctgg ggtgttccgc ggcgtggaca
37021 acgtggttgc ctgcctcggc gacaccgcgg ccgccgccga cggcaccatg acggtgacgc
37081 ttgaagacgt gttaagcaac accgatggcc aggtgatcgc cgtgtatcga ttgcgggcca
37141 gcagggccgg gaaggtcctc gaccagcgcg aggcgatcct ggttaccgtc gccggtggtc
37201 ggatcacccg acttagcgag ttttacgccg acccggcggc gaccgaaagc ttctgggcat
37261 gacggcggcc ttgctttcac cagccatcgc ctggcagcag atctcggctt gcacggaccg
37321 cacgctgacg atcacttgcg aggattccga ggtaatcagc tatcaggacc tcatcgcgcg
37381 cgcggcggca tgcatccccc cgctacggcg tcttgacctc aaacgcggtg aacccgtgct
37441 gatcaccgcc cacaccaacc tggaattcct gtcctgcttt ttgggcctca tgctccatgg
37501 cgctgtgccg gtacccatcc cgccgcggga ggcactgaag accaccgagc gtttcatgac
37561 tcggctcggc ccactgctgc gccatcaccg cgtgctgatc tgcacaccgg ccgaacacga
37621 cgagatacgc gctgccgcca gcaccgactg ccagatcagc agatttactg ccctagccga
37681 ggctggcgac gagcagttcg gccgcgccac ggcccagcaa ctcgccgaca ccgccaccgc
37741 cgactggccg ctatgcaccc tcgacgacga cgcctacgtc caatacacct ctggcagcac
37801 cgcagcacca cgcggagtgg tcatcaccta ccgcaacctg ctgtccaaca tgcgcgcaat
37861 ggccgtgggc tcacaattcc agcacggcga tgtcatgggc agctggctgc ccttgcacca
37921 tgacatgggg ctggtgggca gcctattcgc cgcactcttc aacagtgtca gcgcggtatt
37981 caccacgcca caccggtttc tgtatgaccc gttgggattc ctcagactgc tcaccagctc
38041 cggggctacc cacacgttca tgcctaactt cgctctggag tggctgatca acgcctacca
38101 caggcgcggc gccgacatcg aaggcatcga cctacacaaa atgcgccgct tgatcatcgc
38161 ctccgaaccc gtccatgccg agggcatgcg gagattcgcc gccaccttcg ccggcgtcgg
38221 acttgccccc acggccctgg gttcgggcta tggcctggcc gaagcgaccg tcgccgtgtc
38281 gatgtcagcg cccaacacgg gattccgcac cgaaacccac gccgccgcgg aggtcgtcac
38341 cggcggccga gtgctgcctg gctacgaggt gcgcattgac gccgcaccag gtgcccgggc
38401 cggaacgatc aaactgcgcg gcgacagcgt ggccgccaaa gcctatgtgg gcgggaagaa
38461 gctggacgcg ctcgacgagg aaggcttctg cgacacccac gacttgggtt ttcttgtaga
38521 cgacgaaatc gtcatccttg gccggcagga cgaggtgttc attgtccacg gagaaaacag
38581 attcccctac gacatcgagt tcatcattcg cggggaatcc gagcagcacc ggaccaaagt
38641 cgcatgtttc ggggtcaacg aacgcgtcgt ggttgtgttg gaaagcccat tggacagcat
38701 catcgacaag gccgaagccg accgactgag atgtcaagtc gttgccgcga ctgggctgca
38761 gttggatgaa ctgatcacgg ttcggcgcgg cgcgattccc accaccacca gcggcaagct
38821 caaacgacgc gccgtcgcgc aggcttatcg agacggcaca ctgccccgtc ttgccaccca
38881 cgcgtggacg gcggatcccg atagcgctcc caaaacgacc cggtccagcc tggaaggcgc
38941 ccactgatct tccactgacg tctcatcaaa cccccggggc gctcgcgcgc tgggcgcgct
39001 catcgaccgg ggcttgggtt gattggcccc ggctctcttc gcgcgctggg cgcgctcatc
39061 gaccgcggcc gggtggcccg gcgaaagctt gggcgatcgt cagccagcgt tgtgcgtcct
39121 cccctactgc gttgacgtca agagtgctca gcgcgcgccg ctgggtgacc aggaagcaga
39181 agtcctcggc ggacccggtg acccgctggg ccgcatcgga tggcccccaa gaccaagtgt
39241 cgccgctcgg tccccgcagc tcgaccagga acggctcggc cggaggggtt aggttgttga
39301 cgatgaacgc gtagtcgcgg gtgcggacac cgagatgcgc aatagaccgc agtcgctggg
39361 tggcgggccg gatgacgccc agggcgtcgg cgacgtccag tccatgtgcc caggtctcca
39421 tcaaccgcgc tgttgccatc gacgccgcgc tcatcggtgg cccgaaccag gccaatttgc
39481 ggccatcggg aaccgccagc agttcctcgt gcagccgccc ccgagtgacc cgccagtctg
39541 tgagcagttc ggcaggtgaa acggccgcca gttctgtcgc ggcgtcgtcg acgaaaccgg
39601 ccggattggc cgcggcggcg gtcatcagct cggcgaaccc ggcctcgtcg gtgaccgccg
39661 tcagcgccac tcgatcggtc cacagcaggt ggccgatctg gtgtgcgatg gtccaacccg
39721 gcgcaggtgt cggatcggcc cagcgatccg ctggcagatg cgccaccagc gcgtcgaggt
39781 cgtcgctttc ggcacgcagg tctgccacga acggcccagg atccgccatc accacctcct
39841 gaggtaacag ttcgtcggga aaggcatgtt tgtaccctag cgaccgatca caggctggcc
39901 gcggcgcccg acgatggtgt gcaccaccag cccggctagg tagatcgccg acccgaacag
39961 cacaaatacg ggcgcgtgcc cgtgctcggg aatcaaggct gcggccacgg taatcgagag
40021 gatgtatgag acccaaaaca gtgcatcctg cacggcgaac acgtgcccgc gcaatgcgtc
40081 gtcgacgtcc atctgcatcg ccgaatcggc gcacagcttg accacctggc cggccacacc
40141 taaaaggaag ccgcatacca ccatcaccgg gaccagcagc ccggcggccg cgacctggat
40201 agtggcggcc gcagccaacg cgccatttgc cgtggcgtag cgtccccagc gccggatcgc
40261 ggtcggagtc aagacgttgg ccaggaaggc tcccagcccg gtggccgcga agaacagcag
40321 tgcggtaccc aaccccccaa cggcccgggc ggtcacgtgg cggaccagga gcaagatcag
40381 cagtgagttg ataccgacca ccatccgatg cgctgccaaa ccggacaggc cggcagcgac
40441 ggtcggaagt tgcaccacgg tgcgcgctcc atgtagccaa ccggtgacca cggcgtagac
40501 agcagatccg tggatcgcgc gttcggtgtc gtccgggccg agtacccgcg ggccgaaccg
40561 cagcgaccaa agcaacgcga tcgatacggg gatcgccacc aggaagacga tcgcggaggc
40621 cccctcgtcg ccgctgccga gcagccaacg aggcaacagc atgaagttgg cgcccaggaa
40681 cgcggagacc gcccccgacg cgatggccac cgagttcatc gtgaccacct gttcgcgcgg
40741 caccacgtgg ggcagtgccg ccgacagtcc cgaggcgacg aatcgtgcca agccgttggc
40801 gaccagcgct ccgaccaaca gcggcacgtc gccggctccg accgcgagta tcgtgccgac
40861 cccggcgatc agggctagcc ggccggtgtt ggcgccaacc agcacccacc gccgatccca
40921 ccggtccatt agggccccgg cgaagggccc cagcagcgaa tagggcagaa acagcaccgc
40981 gaaggccccc gcgatggcca tcgggtcggc cgcccggtcc gggttgaaca gcaacgctcc
41041 ggccagcccc gcctgaaaca acccgtcgcc gaactgactc gcaacccgca cctgcagcag
41101 acgccagaag tcgggcaagc tgcgcaccga ccgccaaacg tcgacgggtg cgcgtgcgtg
41161 catccgggag tgaatcacta aacccacttc caccctgggc acaggcaagg ttcggtccac
41221 cccgtgccgc cccaaccaca gtacaaatat tcgccgaccc tgcttgttcg ccccgggcga
41281 tgcgacggtg gtgcgatgat ggtgtggtgg cgccgcacga agaccccgag gaccatgtcg
41341 cacccgccgc acaacgggtg cgagcgggca ccttattgtt ggccaacacc gatctccttg
41401 aaccgacatt tcgccgcagt gtgatctaca tcgtggagca caacgacggc ggcaccctcg
41461 gtgtggtcct caatcggccc agcgaaaccg cggtctacaa cgtgttgccg cagtgggcca
41521 aactcgcggc caagccaaag acaatgttca tcggtgggcc ggtgaagcgc gacgcggcgc
41581 tgtgtctggc ggtattgcgg gttggcgctg acccggaagg cgtgccgggc ctaaggcatg
41641 tcgcgggcag gctggtgatg gtcgatctgg atgccgaccc cgaggtgctc gcagcggcgg
41701 tggaaggggt gcgcatctac gccgggtact ccggctggac catcggtcag ctcgaaggtg
41761 aaatcgagcg cgacgactgg attgtgttgt cggcgttgcc atctgacgtt ttggtggggc
41821 cgagagccga cctgtggggg caggtgctgc gacggcagcc gctgccgctg tcgctgctgg
41881 ccacccaccc gatcgatctg agccggaact aggctactcc gccgccgagc ttgccagagc
41941 agcgcgtcgc gtcgccgcgg tcgagccagg cgatccggcc cagcctagtg ggccacaggc
42001 tgttcaatga caggcctggg tgcagaccgc gcagctgcca acgcagttgg cggtggggct
42061 agcggtttca cggcgcagcg cgtactgggc gctctgccac gaccccgcgg ccagcgtgcc
42121 gaccgcgccc gcaatgcaga cgatcaccac catcaaggcg gtgtgcccgg gcgcggccac
42181 cgccaccact cccccggcgg ccagcattac tgcggctgcc aactgcgtgg gcgccatcgc
42241 gcgcagcgcc agcgccgtgg ggtcggcagt gggcgtatgg cacagcgacc agctcccgaa
42301 cagggcggac gccgccgccg cacacatgca cagcacaccc gcgaggaaca ttcgttcacc
42361 atacgaggcc gccgacgaat ccgctcaccg agctccatgc gggcccgtgt ttctgctcgg
42421 cctcatcgcg acctagcgcg gcgggactgg tgtcagggtg cccgcgggcg gatacccagg
42481 cgcctgcccg ggtagtccca ccggtgccga accgggtgcc ggggcaggcg cctgagcggg
42541 cgccgcatgc gcaaccactt ggaatccgtt gacaatcgca tcggtggccg gcccgtcggt
42601 gaccgcctgc gacagcgcgg tggtcaccga cagcgaaacc aggtacttgt cggctccgga
42661 ggtggcgatg acgtggcgcc gggaggtgtt gagggtcatg tcgttttcgc ggtaggtgcc
42721 ctcgatgatt gatgacggaa agccgtcgaa attggccatc gaggcgtttg tggtctgcca
42781 tgcgagcaat ttctggctgt caatgtagcc gtgtgtgatg gcctcagcgg gatcgaagtc
42841 accgatcagc ctatacacca ccagctgcgc attcgacgtg tagacgctgt tgcccaaccg
42901 gtcggcgatc accacgaacg cgtcgggcac gttggggtcg ggcacctgag tccagcgcgg
42961 cggcatgggc agtgtgatgt cgagcgcctt gaatccgtgc ggtcgctgtg cctccagctt
43021 gacgcccttc tcccggaggt ggtcccgaag tgtgccgctg atcgcgggag tcactggcgg
43081 cggcagcggg ggcacagcgg tggacccggg tgctccgacc ggaatcggcg acgcgatcgg
43141 tgcgggtgct ggcgccggtg agaacctgtt gctgctcccg cccggaagcg ccgtgaggtt
43201 ctgcacgggc gggactgttg ccggcgccga gactggggca gggataggcg gcggtggcag
43261 caggggatcc gctgaggcct tcccggcggt gaccagcacc acgccgatga aaccggtggc
43321 catgccgcct gcgaagaccc gccaggtgcg cgcgatctgg atcatttgcg tcggtccctc
43381 cgaatggccg ggcgacggtg cccgtcgtcg aggctgaatg taaccagcgc tccatggcag
43441 tgcacaggct tgaaatgcag ctggaatgaa cctctgatcg tggtgcaacg gaaccgagac
43501 caacccgtgg ccggtagcgc ggccccggag gttcccgggc cacccttata ccctgttggg
43561 cgtgaccgaa tcgccaaccg ctgggcctgg cggcgtgccc cgtgccgacg acgcggactc
43621 cgacgtgcca cggtaccgct ataccgccga gctcgcggct aggctggaac ggacctggca
43681 ggaaaactgg gcccggctag ggacgttcaa cgtgcccaac ccggtcggct cgctggcccc
43741 accggatggt gccgcggtgc ctgacgacaa gctcttcgtg caggacatgt tcccctaccc
43801 ctcgggtgag ggactccacg ttggtcatcc cctcggctac atcgcgaccg acgtctatgc
43861 ccgctatttc cggatggtgg gccgtaatgt gctgcatgcg ctagggttcg acgcgttcgg
43921 gctgcccgcc gagcaatacg cggtacaaac cggcacccat ccgcgtaccc ggaccgaagc
43981 caacgtcgtc aactttcgcc gccagttggg ccggctgggc ttcggccacg acagccgacg
44041 aagcttctcg accaccgatg tcgacttcta caggtggact cagtggatct tcctacagat
44101 atacaacgcg tggttcgaca ccacagccaa caaggcgcgc ccgatatcag agctggtcgc
44161 cgaattcgag tccggtgcaa ggtgtctcga tggcggccgg gattgggcca agttgaccgc
44221 gggggagcga gccgatgtga tcgacgagta ccggctggtc tatcgggcgg attcgctggt
44281 gaactggtgc ccggggctag gtacggtgct tgccaacgaa gaggtgaccg ccgacggccg
44341 cagcgaccgg ggcaattttc cggtgttccg gaagcggttg cggcaatgga tgatgcggat
44401 caccgcctat gccgaccggc tgctcgacga cctggatgtg ctggattggc ctgagcaggt
44461 caagaccatg cagcgcaact ggatcgggcg ttcgacgggt gcggtggcgc tgttctcggc
44521 gagagcggcc agcgatgacg ggttcgaagt cgacatcgag gtgttcacca cgcggcccga
44581 caccttgttc ggcgccacgt atctggtgct ggctcccgag cacgacttgg tcgacgagtt
44641 ggtcgccgcg tcctggccgg ctggggtcaa ccccttgtgg acatacggcg gcggcacacc
44701 tggtgaggcc atcgccgcct accggcgtgc gatcgccgcc aaatcagacc tcgagcgcca
44761 ggagagcagg gaaaagaccg gcgtcttctt gggcagctac gccatcaacc cggccaacgg
44821 tgagccggtg ccgatcttca tcgccgacta cgtgctggcc gggtacggta ccggggcaat
44881 catggcggtg ccgggtcatg accagcggga ctgggacttc gctcgggcat ttggtctacc
44941 gatcgtggaa gtaattgccg gcggcaatat ttcggaatcc gcgtatacag gcgatggcat
45001 cctggtcaac tcggattacc tcaatggaat gagcgtgcca gcagcaaagc gggccatcgt
45061 cgaccggttg gagtccgcgg gccgcggccg ggctcgaatc gaattcaaat tgcgcgactg
45121 gctttttgcg cggcagcggt attggggtga accattcccg atcgtctatg acagcgacgg
45181 gcgtccgcat gcgctcgacg aagctgcact gcccgtcgag ctgcctgatg tcccggacta
45241 ctcgccggtt ttgttcgacc ccgacgatgc ggacagcgag ccttcgcccc cactggccaa
45301 ggcgactgag tgggtacacg tcgacctgga cctcggtgat ggcctgaagc cctacagccg
45361 cgacaccaac gtgatgccgc agtgggcggg cagctcctgg tatgaactgc gctacaccga
45421 tccgcacaac tcagaacggt tctgcgccaa ggaaaacgag gcctattgga tgggaccgcg
45481 gccggctgag cacggcccgg acgaccccgg tggcgtcgac ttgtacgtcg gcggtgctga
45541 acacgcggtt ttgcacctgc tgtattccag gttctggcac aaggtcttgt acgacctggg
45601 tcacgtcagc tctcgcgagc cttaccgcag gctggtcaat cagggctata ttcaagctta
45661 cgcttacacc gatgcgcgcg gatcctatgt ccctgccgag caggtgatcg aacgcggtga
45721 cagatttgtc tatcctggac ctgacggtga ggtcgaagtt ttccaggaat tcggcaaaat
45781 cggtaagagc ctgaagaatt cggtatcgcc ggacgaaatc tgcgacgcat acggggcaga
45841 tacgcttcgg gtttacgaga tgtcgatggg gccgctggag gcttcacgtc catgggccac
45901 aaaggatgtt gtcggcgcgt accgttttct gcagcgggtg tggcgcttgg tcgtcgacga
45961 gcacaccggc gaaactcggg tggctgacgg cgtggaactc gacatcgata cgctacgggc
46021 gttgcaccgc accatcgtcg gcgtgtcaga agactttgcg gcacttcgca ataacaccgc
46081 aacggctaag ttgatcgaat acacgaacca cctcaccaag aagcatcgtg atgcggtgcc
46141 tcgggccgcc gtggagccgc ttgtacaaat gctggctccg ctggccccac atattgccga
46201 ggagctgtgg ctgcgactgg gcaacaccac ctcgttggca cacggcccgt tcccgaaggc
46261 cgatgccgcc tacctcgtcg acgagacggt cgagtatccg gtgcaggtga acggcaaggt
46321 acgtggccgg gtggtggtgg ccgccgacac cgacgaggaa acgctgaaag ccgccgttct
46381 gaccgacgaa aaggtccagg cattcttggc tggtgccacc ccgcgcaagg ttatcgtggt
46441 cgccggccgg ctggtcaatc tcgtcatcta ggtcgtgtcg gcggtgccga cggtgggcga
46501 ggtaatccgc ggggtagttc gttgtatgcg ttacgccgcg agagccggcg gcgaccagat
46561 tggttgatag cgtggtactt tcacgctcgt ttgcgagcag gggagttgct tgcagggcca
46621 ctggccggtt cgcccgaggc gagacgctcc agtggcgcca gggccttcct gagggtttcc
46681 aagtcggagc ggggaagttg gctgagcagc gcggccagag ccgcgcgccg gttggccagt
46741 gactcaccgt gaaccgcccg cccttgcggc gtgatgtcta ccaacaccgc ccgcaagtcg
46801 gacgggtctc gcgagcgttt caccagtcca atcttctcga gccgccggat cgccacggtg
46861 gtggtgggag ttcgcacccg ttcgtgagcg gccaggtcgg tcatccggat gggaccttga
46921 tcgagcaggg tgaccaggat cgacagttgc gccagcgtta ggtcgccggc tgcagccccg
46981 ttgggatccc cgcggcgcag cattgaaatc agcttggaca atgcgcggtg cagcccctcc
47041 gccagttggg tcacttccgg tgcggtgaat tcgctgtccg ccataaaccg gcagtctaac
47101 ctgacatgcg tgtgaccgta gacttgtgtc gggcgacctt tgaccgccaa tgcatttggt
47161 cccgaaatcc gctgcatttt cttgccaatc gagcggacaa cactcatgtc atggctgact
47221 acctacattg tcagttctgc cggatccatg gtcagtgatg tcgaatgcca ctgaccgcca
47281 acggaaaccg gctctcgcgt taacgggaca gtcaatattg gagacgccgg cagccgctgc
47341 tggcttcacc atcggatcgg cgtaattagg gcaccggtga ggagggctgg tagcttctgg
47401 cgaagccagg gatcggcgcc ccaaacgggc cgggacaagc gccctcgggc gggaccaata
47461 ctcggcggcg gaacagttcg gccagcatcg tctgggccat cagctcggaa cggccgatgc
47521 aggcagccct cgcagcttca ggttcgcgcc gatggattgc ggcgttctct tcctcgtaga
47581 acggcaacac gtcgtcgcgg ctgttttggt atgtcatcca gaacactcgc ggaatcaggt
47641 tctgtgaggc ccggatggtg gcgtgcagcc gcggtcctgc gtactcgtcg ttgaccgtgc
47701 gccggtactc ccacacgcat tcggcgaagg cccgcgactc cttggagttg cgcagcgatc
47761 gcatgactgc gtcgagctgg cccaggatcc gaggcgtggg gttggcggct gcgcgggcag
47821 aggcaatgcc gttgagcaag ccgtcgagtt cgtgatgttc caggatggtg gcgacgtcga
47881 accgctcgat gaacgcgccg cggtgatagc gagtcgacac aatgccgtcg tgttcgagtt
47941 gaaccagcgc ctcttggatg ggaacccggc tgacccccag gccgtgcgcg atttcattgc
48001 ggtcgacgcg gtccccgctg cgcagtttgc cggtcaatag caggttgagg atgtgggcga
48061 caacctggtc cttttcctta accccgtact tttttggcat cggtatctag catctctttc
48121 agcccgctgc agccatccgg cgctggcaag tttctcatga ctcggcgtct gcgttgtggt
48181 gtttcccaga tgaagccggg ggtaacgcga tctgacagac gtcaaccgga gttcaccggc
48241 catcgcgcca cctgcaaagc gcggccgcag cgctcaggtc gtagtcggga ccgtcacagc
48301 caacggtcaa cagcgtgaca ccgagaccgg cgagggcttc ggcgctggcg atcagcccgc
48361 cgccgtcgac cgcggcggag cgttcgatag tcgctgggtt tcggccgacg gtcgagcagt
48421 gcgtgctcag cacggccgac ttcgctaggt agctgtcccc ggcggtaaag ctgtgccaga
48481 tatcggcata ctcggcgacc agtcgcaggg tcttacgctc tccgccgccg ccgatcagca
48541 ccgggatgtc ccgtgtcggc ggcgggttca gcttgccaag ccgcgccttg atccggggca
48601 gcgcagccgc caggtcgtcg aggcggctgc ccgctgtgcc gaaccggtag ccgtactcgt
48661 cgtagtcctt ctgtttccag cccgacccga tacccaggat gagccggccg ccggagatgt
48721 ggtcgacggt acgggccatg tcggcaagca gctccggatt gcggtaggag ttgcacgtca
48781 ctagagcgcc gatttcgatg tgcgacgttt gctcggccca ggctcccaag acggtccagc
48841 attcgaagtg tgggccgtca gggtcgccgt agagcggaaa gaagtggtcc caggtaaaag
48901 cgatgtccac accgatgtcc tcgcaccggc ggacggcgtc tcggacggcg cggtaatggg
48961 gggcgtgctg cggctgcagt tgtacgccga tacgaacggg gagatcggga cgcacgagtg
49021 aagtcatggg tccaccgtag gctcagcgtg tgtcgagcac cccgcgcacg atctcgatca
49081 gggcgcgcgg ttggtcactt tgcaccgagt ggcctgactt ctcgacgatg tgaacgccac
49141 ggaaatgcgt tgcacgcctg tggagttcgg cggtgtcctg gtcggtgacg aagcccgacg
49201 agccgccgcg cacgagtgtg atcggcgcgg acagggcgtc gacgtcgtcc cagagccctg
49261 cgaaatctcc gaacgtgcgg atcgcgtcat agcgccacac ccagttgccg ttgtccagcc
49321 ggcgggagtt gtggaacacg ccgcggcgca acgacttgac atcgcggtgc ggggccgcgg
49381 cgatcgttag gtccagcatg gcctgaaagc tggggaattc ccgctcgccg tgcatcagcg
49441 ccaccgtgcc gcgctgctcg gcggtcagct cggcgtgccg ttgcaatgcc gacggggtga
49501 cgtcgacgag aacgagttcg ccgaccaggt cgggtgccat cgcggccagc cgtatcgcag
49561 tcaacccgcc cagcgacatg ccgaccacga attcggcacc cggcgcaagc tcgcgtagca
49621 ccggcgccaa ggtctcggag ttgagctgcg gcgagtaatt gccgtcctcc cgccaagcgg
49681 aatggccgtg ccctggaagg tccaccgcca gcgccggctc acccaggccg acgatcacgg
49741 tgtcccaggt atgggcgttc tgtccgccgc cgtgcagaaa gatcacccgc ggcgcagagc
49801 cgccccagcg cagcgcgctg atggctcccg cttggacccg ctcgacttca ggcagtggac
49861 cattgacacc ggcctgctca gcgttctcag ccagcagggc aaactcgtcc agtccggtca
49921 gttcgtcgtc agatagcacg cagcggacgt tacccgcgtt tgactctgcg gataccaggc
49981 aattgtgcga gtggcccgcg tggtgagcgc agagtcaacg ctaaccgatg atgaactctt
50041 cgagttgcgc gcgcgcgatg tcgtcgggca gctgctcggg cgggctcttc atcaggtagg
50101 ccgacgccgg gatcaccggt ccgccgatgc cgcggtcctt ggcgatcttg gccgcccgca
50161 ccgcgtcgat gatgacgccg gccgagtttg gcgagtccca cacctcgagc ttgtactcca
50221 ggttcaacgg cacatctccg aaggcgcggc cctcaagacg gacataggcc catttgcgat
50281 cgtcgagcca tccgacgtgg tcggacgggc cgatgtgcac gtccttggtc ttgaactcgc
50341 gcttcagatt cgaagtgacg gcctgggtct tggagatctt cttggactcc agccgttcac
50401 gttcgagcat gttgaggaag tccatgttgc cgcccacgtt gagctgcatg gtgcggtcga
50461 gctgcacgcc gcggtcctcg aacagcttgg ccagcacccg gtgggtgatc gtcgcgccga
50521 cctggctctt gatgtcatca ccgacgatgg gtaccctggc gtcggtgaac ttcttggccc
50581 acaccgggtc ggaggcgatg aacaccggca gcgcgttgac gaacgccacc ccggcgtcga
50641 tagcacactg ggcgtagaac ttgtcggctt cctccgagcc caccggcaaa taggagacca
50701 gcacgtcgac cttggcctcc ttgagcgcct ggacgacgtc gacgggctcc gcgtcggaga
50761 gttcgatggt gtcggcgtag tacttgccga tgccatcgag ggtaggcccg cgctgcacga
50821 tcacgttggt cggcgccaca tcggcgatct tgatggtgtt gttctccgag gcgaagatgg
50881 cgtcggacag gtcgaagccg accttcttgg cgtccacgtc gaacgccgcc acgaacttga
50941 cgtcgcgaac gtggtacggg ccgaaccgca cgtgcatgag gcccggtacg gtcgatgtgt
51001 cgtcggcgtt gtagtagtac tcgacgccct ggaccagcga ggacgcgcag ttgccgacgc
51061 cgacaatggc gactcgaacc tccgtcgacg cctccggcgc cggtaacgac tggtgctcac
51121 tcattaaggc gttctcctaa cctcataacc tctggggtgt cttgggtgtt ggttcgtgct
51181 gggtttacgt ctgttcggcg gggttgggtg ctgcccgttc cgcggcgatg agctcgttga
51241 gccacttgac ctcgcgctcg ctggactcga gcccgagttg atgcaattgg cgggtgtagc
51301 ggtcgaagga actgctggcc cgcgccaccg cctcgcgcaa gccttcccgg cgttcctcga
51361 cctggcggcg ccggccttcc aggatgcgca tccgcgcttc ggccggggtg cggttgaaga
51421 acgccaggtg caccccgaaa ccgtcgtcgg tgtagttgtg tgggccggtg tcggccacca
51481 gctcgccgaa tcgacggcga cccttgtcgg tcagttggta aacgcgtcgt gctcgccgca
51541 ccggggtgcc cgctggggcg gcattctcgg cgatcaaccc gtcggcctgc atgcgtcgca
51601 gcgccgggta taacgaaccg tacgaaaatg cccgaaacgc gcccagcagg ccggtcagcc
51661 tcttgcgcaa ctcgtagcca tgcatcggtg actcgatcaa cagacccagg atggcgagct
51721 ccagcatcga gtcacctcct tttgtatggc ttttgaatgg ccgttacgac ggttcgacgc
51781 ctcgcgtcat cgtatcgcct cgatatattt gcgacaacat caccgcgtca agacgggtag
51841 ctgacgtgct tgatggtgcc gtcacctgcg aaaacgaggt atccaccgcc gtagtcgcta
51901 gagacataca acgacaacga caacgcagcc ggcgtggtgg ggtccttgac cggttcgacg
51961 atcaggtaca tgcttttgac gtcggattgt ttgaggccga gggtttccgg ggcgccgcgc
52021 atgatgccca cagcggtctt cgcatcgaat ttgctcaggt caaccacgga cacgtcggca
52081 atgctcttgg cggaactggt cgcatcgccc cagccgccgc ggtaggtata cgccaggact
52141 cggcggtcgt ccgccgggtc gacgcgatcg agcgacgcat actccgggta gatcaccagc
52201 cggtagccca tggtgtcgcc gaaccgcttg cgggtctgct ccagcaggcc ggtgagcccg
52261 ccgagggaat gcagctgcct gggcggggtc agcaccacgg gggcgatccc gtcgggcttt
52321 gctccgggat ccgaggtgaa gtccagcgga gagcgggtgt tgccgtacac gccccagccg
52381 atgccgacgc ccagcagcac cgatgcgaca aacgcagcgg ccagcaagcc caactcggtg
52441 cgtttcgccc gcgatttgag cgcgggcatt tgtgcgggtg cgctctcgac ctgcaggtcg
52501 gccaccagac gctgcaggtc acctagggtc acagccttgg tagctgcgct gacgcgctcc
52561 cggtgttcct ccatcgagag ctcgccgtca cgcagggcgt cgtcgagaat ccggcaggcg
52621 tcctgccggt cgctgtcttt ggcgcgggtt gccgtcgata ctccgcgcgc aaggggtgcg
52681 cccagccact tcgccacagg gacgatagta ggagtctggc tgggaatctg aactcgatcc
52741 cgccgtaccc gcgcaacaac ggcgccggtt gcgtatcggt ggtgtggatg gcgtcgtact
52801 ctggtcagcg tgcgactgca gcgacaggta gtggactaca cgctacggcg acgctccctg
52861 ctggccgagg tgtattcggg acgcaccggt gtgtcggagg tgtgcgacgc caacccctac
52921 ctgctgcgcg ccgcaaagtt tcatgggaag cccagccggg tcatctgccc gatctgccgc
52981 aaggagcagc tcacactggt gtcgtgggtg ttcggcgagc acctcggtgc ggtatcaggg
53041 tccgcgcgca ccgccgaaga actgatcctg ctggcgaccc ggttctccga gttcgcggtc
53101 cacgtggtgg aggtatgtcg aacctgcagt tggaatcatc tggtcaagtc atacgtcctg
53161 ggcgccgcac gtccggcacg cccccctagg gggtctggcg ggacgcggac ggcgcgcaac
53221 ggggcccgca cggccagtga atagcgacgg gcgtcaccat cagtcgtcca gcggcgcccc
53281 gcgcgggccg gcgaatcccg gccagcgtgg tcaggttcca cccgacgaca gactgaccgc
53341 gatcctcccg ccggtgaccg atgaccgatc ggctccgcac gcggactcca tcgaggcggt
53401 caaggccgcg ctcgacggcg cgccgccgat gcccccgccg cgcgacccgc tcgaggaggt
53461 cacggccgcg ttggccgccc cgcccggtaa accgccgcgg ggggatcagc ttggtggcag
53521 acgtcgccca ccggggccgc ccgggccccc cggttcgtcc ggacagcctg ccggccggct
53581 gccccaaccg agggtggact tgccccgggt cggccagatc aactggaaat ggatacggcg
53641 ttcgctgtac ctcaccgcgg cggtggtgat cctgttgccg atggtcacct tcacgatggc
53701 ctacctgatc gtcgacgttc ccaagccagg tgacatccgt accaaccagg tctccacgat
53761 ccttgccagc gacggctcgg aaatcgccaa aattgttccg cccgaaggta atcgggtcga
53821 cgtcaacctc agccaggtgc cgatgcatgt gcgccaggcg gtgattgcgg ccgaagaccg
53881 caatttctat tcgaatccgg gattctcgtt caccggcttc gcgcgggcag tcaagaacaa
53941 cctgttcggc ggcgatctgc agggcggatc gacgattacc cagcagtacg tcaagaacgc
54001 gctggtcggt tccgcacagc acgggtggag cggtctgatg cgcaaggcga aagaattggt
54061 catcgcgacg aagatgtcgg gggagtggtc taaagacgat gtgctgcagg cgtatctgaa
54121 catcatctac ttcggccggg gcgcctacgg catttcggcg gcgtccaagg cttatttcga
54181 caagcccgtc gagcagctga ccgttgccga aggggcgttg ttggcagcgc tgattcggcg
54241 gccttcgacg ctggacccgg cggtcgaccc cgaaggggcc catgcccgct ggaattgggt
54301 actcgacggc atggtggaaa ccaaggctct ctcgccgaat gaccgtgcgg cgcaggtgtt
54361 tcccgagaca gtgccgcccg atctggcccg ggcagagaat cagaccaaag gacccaacgg
54421 gctgatcgag cggcaggtga caagggagtt gctcgagctg ttcaacatcg acgagcagac
54481 cctcaacacc caggggctgg tggtcaccac cacgattgat ccgcaggccc aacgggcggc
54541 ggagaaggcg gttgcgaaat acctggacgg gcaggacccc gacatgcgtg ccgccgtggt
54601 ttccatcgac ccgcacaacg gggcggtgcg tgcgtactac ggtggcgaca atgccaatgg
54661 ctttgacttc gctcaagcgg gattgcagac tggatcgtcg tttaaggtgt ttgctctggt
54721 ggccgccctt gagcagggga tcggcctggg ctaccaggta gacagctctc cgttgacggt
54781 cgacggcatc aagatcacca acgtcgaggg cgagggttgc gggacgtgca acatcgccga
54841 ggcgctcaaa atgtcgctga acacctccta ctaccggctg atgctcaagc tcaacggcgg
54901 cccacaggct gtggccgatg ccgcgcacca agccggcatt gcctccagct tcccgggcgt
54961 tgcgcacacg ctgtccgaag atggcaaggg tggaccgccc aacaacggga tcgtgttggg
55021 ccagtaccaa acccgggtga tcgacatggc atcggcgtat gccacgttgg ccgcgtccgg
55081 tatctaccac ccgccgcatt tcgtacagaa ggtggtcagt gccaacggcc aggtcctctt
55141 cgacgccagc accgcggaca acaccggcga tcagcgcatc cccaaggcgg tagccgacaa
55201 cgtgactgcg gcgatggagc cgatcgcagg ttattcgcgt ggccacaacc tagcgggtgg
55261 gcgggattcg gcggccaaga ccggcactac gcaatttggt gacaccaccg cgaacaaaga
55321 cgcctggatg gtcgggtaca cgccgtcgtt gtctacggct gtgtgggtgg gcaccgtcaa
55381 gggtgacgag ccactggtaa ccgcttcggg tgcagcgatt tacggctcgg gcctgccgtc
55441 ggacatctgg aaggcaacca tggacggcgc cttgaagggc acgtcgaacg agactttccc
55501 caaaccgacc gaggtcggtg gttatgccgg tgtgccgccg ccgccgccgc cgccggaggt
55561 accaccttcg gagaccgtca tccagcccac ggtcgaaatt gcgccgggga ttaccatccc
55621 gatcggtccc ccgaccacca ttaccctggc gccaccgccc ccggccccgc ccgctgcgac
55681 tcccacgccg ccgccgtgac cggcgcgctg tcccaaagca gcaacatctc gccacttcct
55741 ttggccgccg atctgcggag cgccgataac cgcgattgcc ccagccgcac cgacgtattg
55801 ggtgccgctc tggcgaatgt cgtcggtggc ccggtaggcc ggcacgcgct gatcggccgc
55861 acccggctga tgaccccgct gcgggtgatg tttgcaatcg cgttggtgtt cctggcgctc
55921 ggttggtcga cgaaagcggc ctgcttgcag tccaccggaa ccggtccagg tgatcagcgg
55981 gtggccaact gggataacca gcgtgcttac taccagttgt gctactccga tacggtgccg
56041 ctctatggcg ctgagttatt gagccaaggc aagtttccgt acaaatcaag ctggatcgaa
56101 accgacagca acggcacacc gcagctgcgc tacgacggac agatcgcggt gcgctatatg
56161 gagtatccgg tgctgactgg gatctatcag tacctgtcga tggcgatagc caagacctac
56221 accgcgttaa gcaaggtggc tcccctcccg gtggttgccg aagtggtgat gttcttcaac
56281 gtcgccgcgt tcggtttggc gctggcgtgg ctgacaaccg tctgggcgac ctcgggcctg
56341 gccggccgcc ggatatggga tgcggcgctg gtggccgcct caccgctggt gatctttcag
56401 atattcacca atttcgatgc gctggcaacg ggtttggcga cgagtgggct gctggcctgg
56461 gcgcggcgca gaccggtgct tgccggtgtg ctgatcgggt tgggctccgc ggcgaaactg
56521 tatccgctgt tgttcttgta cccgttgttg ctgctgggca tccgggccgg tcgcctgaat
56581 gctctggccc gcaccatggc ggccgcggcg gcgacctggt tgttggtgaa tctgccggtg
56641 atgctgctct ttccgcgcgg ctggtcggag ttcttccggc tcaacacccg gcgcggcgac
56701 gacatggact cgttgtacaa cgtcgtcaag tcgttcaccg gctggcgtgg cttcgacccc
56761 accctgggct tctgggagcc gccgctggtg ctgaacacgg ttgtcacgct cttgttcgtg
56821 ttatgttgtg cggcaattgc ttacatcgcg ctcaccgcac cccaccggcc gcgcgtggcg
56881 cagctgactt tcttgacggt ggccagcttc ctgttggtca acaaggtgtg gagtccccag
56941 ttctcgcttt ggctggtgcc gctggccgtg ctggctttgc cgcaccgccg gatcttgctg
57001 gcgtggatga cgatcgacgc gttggtgtgg gtgccgcgga tgtactacct atacggcaac
57061 ccgagccgct cgctgcccga gcagtggttc accacgacgg tgttgctgcg tgacatcgcc
57121 gtgatggtgc tgtgcggact ggtggtctgg cagatctacc gccccgggcg cgacctcgtg
57181 cgtaccggcg ggccaggggc actgccggct tgtgggggag tcgacgaccc ggtgggaggg
57241 gtctttgcca acgccgccga cgccccgcca ggtcggctac cgtcgtggct gcgtccccgg
57301 ctgggcgacg agcatgcgcg agagaggacg cccgatgcag gtcgcgatcg cactttttcc
57361 gggcaacacc gcgcttgacg cggttggccc ctacgaggtg ctgcagcggg tgccgtcgtt
57421 cgacgtcgtg ttcgtcggcc accgccgcgg ggaggttcgc agcgacaacg ccatgctggg
57481 tctgctgtgt gacgcggcat tcgacgagct aacccggccc gatgtggtga tctttccggg
57541 cggcatcgga actcggaccc tgatccacga ccagaccgtg ctcgactggg tgcgcgaagc
57601 gcaccggcac accctactca ccacctcggt gtgcaccggc gggctggtgt tggcggctgc
57661 cggactgctc aacggcttga ccgcgaccac gcattggcga gtacaggatc tgttcaactc
57721 gctgggcgcc cgatacgtcc cccagcgtgt cgtcgagcat ctgccagagc gggtcatcac
57781 cgccgccggg gtgtcgagcg ggatcgacat gggattgcgg ctggtggagc ttttggtcag
57841 ccgggaagcc gccgaagcga gccagctgat gatcgagtat gacccgcagc caccggtgga
57901 tgccggctcc ctggccaagg cctcgccggc tacccatcgg ctcgcgttgg agttctatca
57961 gcatcgtttg tgatctgttc gcgataggcc tcgccgttcg cgacactgac attgcgcaca
58021 cgacacgccg cggatcgtcg caccgggtta agcctggagt gcggtggtgc ctggtcggca
58081 ttttcgcagt cgagggctct cgtgtagcct gggcgagttg ccgacgcagg cgaccctcct
58141 gccacggatc gaccgtggcc gcacacgacc acaggaggtg atgaggttcc tatgcgtcca
58201 tacgaaatca tggtcatcct cgacccgacc ctcgacgaac gcaccgtagc cccgtccttg
58261 gagacgttcc tcaacgtcgt ccgtaaggac ggcggaaaag tcgaaaaggt ggacatctgg
58321 ggcaagcgtc ggctggcgta cgagatcgcc aagcatgccg aaggcatcta cgtggtgatc
58381 gacgtgaaag ccgccccggc gacggtgtcc gaactcgacc gccagctcag cctcaacgag
58441 tcggtgttgc gcaccaaggt aatgcgcacc gacaagcact aatcggcctg ccaggcactg
58501 gctgttcgct gtcggtgcgg ttacgtaggc tcggcgaaga agaacacgac cagccgccga
58561 acccaggcgg acgcaggagg aaattgtggc tggtgacacc accatcacca tcgtcggaaa
58621 tctgaccgct gaccccgagc tgcggttcac cccgtccggt gcggccgtgg cgaatttcac
58681 cgtggcgtca acgccccgga tctatgaccg tcagaccggc gaatggaaag acggcgaagc
58741 gctgttcctc cggtgcaata tctggcggga ggcggccgag aacgtggccg agagcctcac
58801 ccggggggca cgagtcatcg ttagcgggcg gcttaagcag cggtcgtttg aaacccgtga
58861 gggcgagaag cgcaccgtca tcgaggtcga ggtcgatgag attgggcctt cgcttcggta
58921 cgccaccgcc aaggtcaaca aggccagccg cagcggcggg tttggcagcg gatcccgtcc
58981 ggcgccggcg cagaccagca gcgcctcggg agatgacccg tggggcagcg caccggcgtc
59041 gggttcgttc ggcggcggcg atgacgaacc gccattctga ccccaagaac tgcaaatcaa
59101 gaaacggaaa gatagacact catggccaag tccagcaagc ggcgcccggc tccggaaaag
59161 ccggtcaaga cgcgtaaatg cgtgttctgc gcgaagaagg accaagcgat cgactacaag
59221 gacaccgcgc tgttgcgcac ctacatcagc gagcgcggca agatccgcgc gcgtcgggtc
59281 acgggcaact gcgtgcagca ccagcgagac atcgcgctcg cggtgaagaa cgcccgcgag
59341 gtggcgctgc tgccctttac gtcttcggtg cggtagcgcc gaatgtccaa cggagagtgc
59401 aaaataccat gaagctcatt ctcacggccg atgtcgatca cctcgggtcc atcggcgaca
59461 ctgtcgaggt caaggacggg tatggccgta actttctgct cccgcgcggc ctggcgatcg
59521 tcgcctcgcg cggagcccag aagcaggctg acgagatccg ccgggcccgc gaaaccaaaa
59581 gcgtacgcga cctagagcac gccaacgaga tcaaggcggc gatcgaggcg ctcggcccga
59641 tagcgctgcc ggtgaagact tcagctgatt ctgggaagtt gttcggctcg gtgaccgccg
59701 cagatgtggt tgctgccatc aagaaggccg gtggaccaaa cctcgataag cggatcgttc
59761 ggctgcccaa gacgcacatc aaggccgtgg gcacgcattt tgtgtcggtg cacctgcacc
59821 cggaaatcga tgtcgaggta tcgctggacg tcgtggcgca gagctaaggc gagctgaggc
59881 cacaacagtt tgcgcatgcc ggtggtgacc gcggtcggcc gccgccgggg tttcgccatg
59941 ccctgggtgt ccaccgcacg gtccggtgcg gtgatgctgg cgaactattc ggccggcgtt
60001 tgcgggcggg tgtcttcacc gggccttaac gtcaggaaaa tgtgtctgaa agccaacacg
60061 cccggcgcgg taacctggct cgacacgccg aagagattct tgtccacaca aacggcgtcg
60121 cgttgtatgg ccgttaacag cagtgatgtc gtaacgggcc gtattgatcc acaggttctc
60181 cacaccccgc tcaacacaga cgtcgacgga tatgcacatg cgatgcacag ctccataaac
60241 agtggcccct tggagtactt gccagcaacg tttagcgtct tcccggcgct aggcgatgtg
60301 ggtgacttgg gcggtggtgt cggtgcggcg acttacgctc tggataggtt gtcgaatatg
60361 cgttcgggtg cttgtgtcgg aggaggtgag agcccatggc ggtcgttgat gacctagcgc
60421 ccggcatgga ctcctcaccg cccagtgaag attacggccg tcaaccaccg caggatctcg
60481 ccgccgagca gtccgtgctg ggcgggatgt tgctgagcaa ggacgccatc gccgatgtac
60541 tggaacggct acggcccggc gatttttatc gtccggcgca tcagaacgtc tacgacgcca
60601 ttttggacct gtatgggcgg ggagaaccgg ctgatgcggt gacggtggcc gccgaactgg
60661 atcgccgtgg gctgctgcgc cgcatcggcg gtgctcccta cctgcacacc ctgatctcga
60721 cggtgccgac ggccgccaac gcgggctact acgcgagcat cgttgccgaa aaggcgctgc
60781 tgcgccggct ggtagaggcc ggaacccggg tggtgcagta cggctatgcc ggcgccgaag
60841 gcgcggatgt ggccgaggtg gtcgatcgcg cgcaggccga aatctacgac gtcgcggatc
60901 ggcggctgtc ggaagacttt gtggcgcttg aggacctgct gcaaccgacg atggacgaga
60961 tcgatgccat cgcttccagt ggcggcctgg cgcgcggggt ggctaccggc ttcaccgaac
61021 tcgacgaggt caccaacggc ctgcatccgg ggcagatggt catcgtggcg gcgcgcccgg
61081 gcgtgggaaa gtccaccctt gggctggact tcatgcggtc atgctcgatc aggcatcgga
61141 tggccagcgt catcttctcg ctggagatga gcaagtccga gattgtcatg cgactgctgt
61201 cggcggaggc caaaatcaag ctctccgaca tgcgttcggg ccggatgagc gatgacgact
61261 ggacccggct ggcgcggcgg atgagcgaaa tcagcgaagc gccactgttt atcgacgact
61321 cgcccaacct gaccatgatg gagatccgtg ccaaggcgcg ccgcctgcgg caaaaggcca
61381 acctgaagtt gatcgtggtc gactacctgc aactgatgac ctcgggcaag aagtatgaat
61441 cacggcaggt ggaggtgtcg gagttctcgc ggcatctgaa gctgttggca aaagagcttg
61501 aggttcccgt ggtcgcgatc agccagctca accgtgggcc cgagcagcgt accgataaga
61561 aaccgatgct ggccgacctc agggaatcgg gctgcctgac cgcgtccacc agaatcttgc
61621 gcgccgatac cggcgctgag gtcgccttcg gtgagctcat gcgaagcggt gaacgtccca
61681 tggtgtggtc gctggacgag cggctgcgca tggtggcccg gccgatgatc aacgtgttcc
61741 cgagcgggcg caaggaagtg tttcggcttc ggctggcttc cggacgcgaa gtcgaggcca
61801 ccggcagcca cccctttatg aagttcgaag gctggactcc cttggcgcag ttgaaggttg
61861 gtgaccggat cgcagcaccg cgccgggtac ctgagcccat cgacactcag cggatgcccg
61921 agtctgagct catttcgctg gctcgcatga tcggtgacgg gtcgtgcctg aagaaccagc
61981 cgatccgcta cgagccggtg gatgaggcga acctggccgc ggtgacggtc tcggcggcgc
62041 actcggatag ggctgcgatc cgcgacgact acctcgcagc tcgagtgccg tcgttgcgcc
62101 cggcgcggca acgactaccg cgcgggcggt gcacgccgat tgcggcgtgg ctggctggcc
62161 tagggctatt cacgaaacgc agccacgaaa aatgcgtacc ggaggctgta tttcgcgccc
62221 ccaatgacca ggtggcgttg tttctgcggc atctgtggag cgctggtggc tctgttcggt
62281 gggatcccac gaatggtcaa ggccgggtct actacggctc aaccagtagg cgtctcatcg
62341 acgatgtggc tcaattgctg cttcgggttg ggattttttc ctggatcaca cacgccccaa
62401 agttgggcgg ccacgattcg tggcggctgc acattcatgg cgcgaaggat caggtcaggt
62461 tccttcgtca cgtcggcgtt cacggcgccg aagcggtggc ggcccaagag atgctgcgtc
62521 agctcaaagg accggttcgc aacccgaacc tggacagcgc gccgaaaaaa gtatgggcgc
62581 aagtccgcaa ccgactgtcc gccaaacaga tgatggacat ccagctccac gaaccgacga
62641 tgtggaagca ttccccgagc cggtcaaggc cgcatcgcgc ggaggcgcgg atcgaagatc
62701 gagcgatcca tgagctggcg agaggcgacg cgtactggga caccgtcgtg gagatcacca
62761 gcattggaga tcaacatgtt ttcgatggga ctgtaagcgg cacacacaat ttcgtcgcca
62821 atggcattag tttgcacaat tcgctggaac aagatgccga cgttgtcatc ctgctgcatc
62881 gacccgacgc ctttgaccgc gacgatccac gtgggggaga agcggatttc attctcgcca
62941 aacaccgcaa cggtccgacg aagacggtca ccgtagcgca tcaactgcac ctgtcacgct
63001 tcgccaacat ggctcggtga catgcggatg tgtggggtct cacggagcgt ggccgaatct
63061 cacgaatgat ggggccatca gggcggaccg gtccacgcat ccgcggcggc gttgaagtcc
63121 ccgagcaaca cgcgtcgtgg ttgatgcgtg agatgagtca gatcagggcg acaggacgtc
63181 gaaccagtgg gactaatgca tgatcaccag atacaagcct gagtcggggt ttgtcgcccg
63241 tagcggtggt cccgaccgga agcgtcccca tgactggatc gtttggcact tcacccatgc
63301 cgacaatctc cctgggatca tcaccgctgg ccgtctgctg gccgattcag cagtcacccc
63361 gacgaccgag gtggcatata acccagtcaa ggagttgcgc cgccacaaag tcgtcgcccc
63421 cgacagcagg tacccggcgt cgatggcaag cgatcatgtg ccgttctaca ttgcggcgcg
63481 gtcgcccatg ctctacgtcg tatgcaaggg ccactccggc tactccggcg gtgccggccc
63541 gctggtgcac ctcggggtgg cgcttggcga catcatagac gcggatctga cgtggtgcgc
63601 cagtgacggc aatgctgcag ccagctacac caagttcagc cgccaggtcg acacgctcgg
63661 caccttcgtc gactttgacc tgctctgcca gcggcaatgg cacaacaccg atgacgaccc
63721 caaccgccag agccgccgcg ccgccgagat cctggtatac ggccatgtcc cgttcgagct
63781 ggtcagctac gtgtgttgct ataacaccga gacgatgaca cgggtacgaa ctctgctcga
63841 tcctgtcggt ggggtgcgaa agtatgtcat caagcccggc atgtactact aaggaaggag
63901 gaggccatat gatcacgtac ggctctggcg acctccttcg ggctgacacc gaagcgctcg
63961 tcaacaccgt caactgtgtt ggggtgatgg gcaagggaat tgcgctgcag ttcaaacgcc
64021 gctaccccga gatgttcacc gcctacgaaa aggcgtgcaa acgcggcgaa gttaccatcg
64081 gcaagatgtt cgtcgtcgac accggacagc tcgacggacc gaaacacatc atcaacttcc
64141 ccaccaagaa acactggcgt gcaccgtcga agctggccta tatcgacgcc ggcctcattg
64201 atctcatccg cgtgatccgt gaactcaaca ttgcttctgt ggcagttccc ccgctggggg
64261 tgggcaacgg aggtctggat tgggaagatg tcgagcaacg gctcgtatca gcattccagc
64321 agctgcccga cgttgacgcc gtgatctacc ccccatcagg tggatctcgc gccatcgagg
64381 gcgtcgaagg acttcggatg acctgggggc gcgccgtcat actcgaagcg atgcggcgat
64441 atctccagca gcgccgcgcg atggagccgt gggaagaccc tgcagggatc tcgcatctgg
64501 agattcagaa gctcatgtac ttcgccaacg aggccgatcc cgatcttgcg ctagatttca
64561 cgcccggccg atacgggcca tacagcgaac gtgtccgtca cttactgcaa ggaatggagg
64621 gcgcattcac agtcggcctg ggtgacggca ccgcaagagt tcttgcgaac caaccgatct
64681 cgttgactac taagggaact gacgccataa cggactatct ggccaccgat gcggcagctg
64741 accgggtgag cgccgcagtc gacacggtgt tgcgcgtcat cgaaggcttt gaaggcccat
64801 acggggttga gctgctcgcc agtacgcatt gggtggccac acgtgagggc gccaaggaac
64861 cagccacggc agcggccgcg gtccgaaagt ggacaaaacg caagggtcgg atctacagcg
64921 acgatcgcat cggtgttgcc ctcgaccgca ttcttatgac tgcctgaaag cgaccggctc
64981 gtcgttaagg atgtgcgccg acgcccagcc gtcagggagc gttgggctgc tcggacggaa
65041 ttgccccacc gcaaccaccc ggtggcggcg ggccggggag gggctcaccg ccgctgacac
65101 aatcgaagta aaactgtggg ccggtaaacc acgtttgcat ccactggtgc caaaacgagc
65161 cgtcggggta cttctcgccg tcgcacacgg ccaagtcgcc aaaaccccat cggccacccg
65221 ggcaatagcc tttcgtcatg tccggctgat gcgggtcagg tggatctgcg ctggcaaccg
65281 aggcaggaaa cacaagcgcc gctgcacaac ccagtatcgc agtactcagg cgagcaaact
65341 tcaacttcat ttcaaactcc gtcaaacgtt gaatcgactc ggcggactcc aagcgatggt
65401 cagcgcttgc ggatgagccg cggcaatgag tcgtagtggg cagacattcc cgagaacagc
65461 ctgaaatcct gttcggttga tgccgtgccg gcatcgacgt accaggacga ggcactgact
65521 cgggaaggca cagccgccgt ggcgattgta tatgacgcgt cggactgggc agcgatggcg
65581 cgggactctg cccgggcgcc ggccttggac acggccagcg cccgccacct gtcgtcggca
65641 tttggcgttt gtcgaattgc ggcattattt tgctcgggtg atgtcatcag ctattggttc
65701 ggtcgcgcgg tggatagtcc ccctcctggg ggttgcagcc gttgcttcca tcggtgttat
65761 cgcggacccg gtgcgggtcg ttcgggcccc ggcgttgatc ctggtcgatg cggcaaaccc
65821 gctggccgga aagcccttct acgtcgatcc cgcctcggcg gccatggtcg ccgcgcgcaa
65881 cgccaacccg ccgaacgccg agctgacctc cgtcgccaac accccgcagt cctactggct
65941 cgaccaggca ttcccgccgg cgaccgtcgg cggcacggtt gccaggtaca ccggagcggc
66001 gcaggcggcc ggcgccatgc cggttctgac gctgtatgga atcccccatc gcgactgcgg
66061 tagctacgca tccggtgggt tcgcgacggg cactgattac cgcgggtgga tcgacgctgt
66121 cgcatccggc ctgggctcat cgccggcgac gatcatcgtc gaacccgatg cgctggccat
66181 ggccgactgc ctgtcgcctg accagcgcca ggaacgtttc gacttggtgc gctacgccgt
66241 cgacacgctg acccgcgacc cggccgctgc cgtgtacgtc gatgcggggc attcgcgctg
66301 gctgagcgcc gaggcaatgg ccgccaggct caacgatgtc ggtgtgggcc gcgcgcgcgg
66361 gtttagcctc aacgtctcga acttctacac caccgatgag gaaatcggct atggcgaggc
66421 gatttcgggg ctcacgaacg gttcgcatta cgtgatcgac acgtcgcgca acggcgccgg
66481 acccgcgccc gacgccccgc tcaactggtg taaccccagc ggccgcgccc tgggcgcacc
66541 gcccaccacg gcgaccgcgg gcgcgcacgc cgacgcttac ctgtggatca aacgtcccgg
66601 ggaatcggac ggaacctgcg gtcgcgggga gcctcaggcg ggtcggttcg ttagccagta
66661 cgccatcgat ctggcccaca acgccggcca gtagagacct cacgcgcaga ccggctgagc
66721 gtgcggccgt tgggccgtcg gcgtcgggtt cggccaggtg gggtaacggt tcgggcacgt
66781 ttccactacc tcgtgacacg tcatgcggca ccgcggttcg ggtggtcgac aatgcgggac
66841 atgacccaaa attcggggtg ctgccggccc gcagcgtcgg gctgcgccgc gctggtgacc
66901 gtcgcgagac gggagcccga cgttggcgcg tgagatctca cgccagacgt ttctgcgggg
66961 tgccgccgga gcgttggccg ccggcgcggt cttcggctcg gtccgggcta ccgcggatcc
67021 ggctgcctct ggctgggagg ctctttcttc cgccctcgga gggaaagtgc tacaaccgga
67081 cgacggtccc caattcgcaa cggccaagca ggttttcaac accaactaca acggctatac
67141 gccggcggtg atcgttaccc cgacatcgca gctggacgtg cagaaggcga tggcgttcgc
67201 tgccgcgaac aacctcaagg tggccccacg cggtggcggg cactcctacg tgggggcgtc
67261 cacggccaac ggcgccatgg tgctcgacct acgtcagcta cctggggaca tcaactacga
67321 cgccaccacc gggcgggtca cggtgacgcc cgccaccggt ttgtacgcca tgcaccaggt
67381 gttggccgcg gccggccggg gcatcccgac cggcacctgc ccgacggtcg gtgtcgcggg
67441 acacgcgctg ggcggcgggc tgggcgccaa ttcccggcac gccggcctgc tctgtgacca
67501 attgacgtcg gcgtcggtgg tgctgcccag cggccaggcg gtcaccgcgt ccgccaccga
67561 ccaccccgac ctgttctggg cgttgcgcgg tggcggtggc ggcaacttcg gcgtgacaac
67621 ctcgctgacc ttcgcgacgt tccccagcgg ggacctcgac gtcgtgaacc tcaatttccc
67681 accgcagtcg ttcgcgcagg ttctggtcgg ttggcagaat tggctgcgaa ccgccgaccg
67741 aggcagctgg gcactggccg atgccaccgt cgacccgctg ggcacgcatt gccgcatcct
67801 tgcgacctgc ccggccgggt cgggcggcag cgtggcggcc gccatcgttt cggccgtcgg
67861 aacgcaaccg accggcaccg aaaaccacac gttcaactat ctggacctgg tcagatatct
67921 ggccgtcggg aacctcaacc cgtcgccgct gggatatgtc ggcggatccg atgtcttcac
67981 gacgatcact ccggcgaccg cccagggaat cgcctcggcg gtcgacgcct ttccgcgtgg
68041 agcgggccgc atgttggcga tcatgcacgc cctcgacggc gcgctcgcca ctgtgtcacc
68101 gggggccacg gccttcccgt ggcgtcggca gtcggcgctg gtgcagtggt acgtcgaaac
68161 atccggctcc ccgtcggaag cgactagctg gctcaacacc gcacatcaag cggtgcgagc
68221 gtattcggtt ggcggctatg tgaactatct cgaggtaaac caaccgccgg cacgttactt
68281 tggcccgaat ctgtcccggc tgagcgcagt acgtcagaag tatgacccca gccgggtcat
68341 gttctccggg ctgaacttct agcagccccg catgagtact agcccctagg acgggccatc
68401 ctcgtctacc ctgggaagtg atcatggaac tttccgtgtc tgttatcgcg gggttggtca
68461 tcgcactgct ggcggccatc acccctgctg cgggcgaacg cccggaaagc cgccgccagg
68521 cgctcgcaaa tgccgccgag gccggggagc atccggccac atcaccgttg cgacggtagc
68581 cgattcgtcg cgatacggct gtggagttag gaggcgcgga tggagacagg ttcgccggga
68641 aaacgtccgg tcttgcccaa gcgtgcccgc ctgctggtga cggcaggcat gggcatgctc
68701 gcgttgctgc tgtttggacc ccggctagtc gatatttacg ttgactggtt gtggtttggt
68761 gaggtcggtt tccgcagcgt ctggatcacg gtactgctga cccgcctggc gattgtcgca
68821 gcggtcgcac ttgtggtggc cggcattgtg cttgctgccc tactgctggc gtatcgctcg
68881 cggccgttct ttgtacccga cgagccgcag cgggacccgg tcgcgccact tcgcagcgcg
68941 gtgatgcgcc ggccgcgcct gttcgggtgg ggcatcgccg tcacgctcgg tgtggtgtgc
69001 gggctgatcg cttcgttcga ctgggtgaag gttcagttgt tcgtacacgg gggcaccttt
69061 ggcatcgtgg accccgaatt cggctatgac attgggtttt tcgtcttcga tctgccgttc
69121 taccggtcgg tgctgaactg gctgttcgtg gccgtggttc tggcgtttct agcgagcctg
69181 ttgacgcatt acctgttcgg cggccttcgg ctgacaaccg gcagaggcat gctgacccag
69241 gcagctcgcg ttcaactcgc agtgttcgcc ggcgcggttg tactgctgaa ggcggttgcc
69301 tactggttgg atcgctatga gctgttgtcg agtggacgta aggagccgac cttcaccggc
69361 gccggctaca ccgatatcca cgccgagctg ccggccaagc ttgtgctggt ggcgattgcg
69421 gtattgtgtg cggtgtcatt ctttaccgcg atctttttgc gcgacttgag gattccggcg
69481 atggccgccg cactgctggt gctgtcggcg atcctggtcg gtggactgtg gccgctgctg
69541 atggagcagt tctcggtgcg tcccaacgcc gccgatgtcg aacgcccata tatccaacgc
69601 aacatcgaag cgacccgcga ggcgtatcgg atcggtggcg attgggtcca gtaccgtagc
69661 tatccgggca tcggtaccaa acagccgcgc gacgtgcccg tggatgtcac cacgattgcc
69721 aaggtgcggc tgttggaccc gcatatcctg tcccgaacct tcacccagca acagcagctc
69781 aagaatttct ttagcttcgc cgagatactc gacatcgatc gctatcgcat cgacggtgag
69841 ctgcaggact acatcgtcgg cgtccgggag ctctcgccga aaagcctcac cggcaatcag
69901 accgactgga tcaacaaaca caccgtctac acgcatggca acggcttcgt ggccgccccg
69961 gccaatcggg tgaacgcggc ggcccgcggt gccgagaata tttccgacag caacagcggg
70021 tacccgatat acgccgtcag tgacatcgcg tcgctgggtt ctgggcgcca ggtcatcccg
70081 gtcgagcagc cacgggtcta ctacggcgag gtgatcgccc aggccgatcc ggactacgcg
70141 atcgtgggcg gagccccggg gtccgcgccg cgcgagtatg acaccgacac gtccaagtac
70201 acctataccg gcgccggggg tgtgtcgatc ggaaactggt tcaaccgcac ggtgtttgcc
70261 accaaggtcg cccagcacaa gttcctgttc tcccgggaga tcggctcgga gtcgaaggtg
70321 ttgatccatc gcgacccgaa ggaacgggtg caacgcgtgg cgccgtggtt gaccaccgac
70381 gacaacccct atccggtggt ggtgaacggg cggatcgtct ggatcgtcga cgcctacacc
70441 accttggaca cctatccgta cgcacaacgc agctcgctcg agggcccggt gaccagcccg
70501 accggcattg tgcggcaagg caagcaggtg tcgtacgtgc gtaactccgt caaggcaacc
70561 gtggacgcct acgacggaac cgtaacgctg tttcagttcg atcgagacga cccggtgctg
70621 cggacctgga tgcgtgcctt tcccggaacc gtcaagtccg aagaccagat tcccgacgag
70681 ttgcgtgccc acttccgtta tccggaggac cttttcgagg tccaacgtag cttgctggcc
70741 aagtatcatg tcgacgaacc gcgagagttc ttcaccacca acgccttctg gtcggtgccc
70801 agcgacccga ccaacaacgc taacgccact caaccgccgt tctacgtcct cgtcggcgac
70861 cagcagagcg cccagccgtc cttccggttg gcgtcggcga tggttggcta caaccgcgaa
70921 ttcctctccg cgtacatctc ggcgcactcg gatccggcga actacggcaa gctgaccgtg
70981 ctggagttac ccaccgacac cctgacccaa ggcccgcaac aaattcagaa ctcgatgatc
71041 tccgacactc gggtcgcctc cgagcgcacc ctgctggaac ggtcaaaccg gattcactac
71101 ggcaacctct tgtcgctgcc gatcgccgac ggcggcgtgc tctatgtgga accgctctac
71161 accgagcgga tctcgacaag cccgagcagt tcgactttcc cgcaactttc ccgggtgctg
71221 gtcagcgtgc gtgaaccccg caccgagggc ggggtccggg tcgggtacgc accgaccctg
71281 gccgaatctt tggatcaggt atttgggccc ggcaccggtc gggtcgccac cgctcgcggc
71341 ggtgatgccg ccagcgcgcc accgccggga gccggcgggc cggcaccgcc gcaggccgta
71401 ccgccaccga gaacgaccca accgccggcc gccccgcccc gggggccgga cgtccccccc
71461 gcgacggtgg ccgaactgcg ggaaacgctg gccgatctgc gcgcggtgct cgaccggtta
71521 gagaaggcca tcgatgccgc cgaaacgccc ggtggataag ccggcattct tagccggtga
71581 actccgctat ggctaccatt caagttcggg atttgcccga agatgtcgcc gaaacctatc
71641 gacggcgcgc caccgcagcg gggcagtcgc tgcagacgta tatgcgcacc aagctcatcg
71701 aaggggtgcg gggccgagac aaggccgagg caatcgagat cctggaacag gcgctcgcca
71761 gcactgccag cccaggcatc agccgggaga ccatcgaggc atcccggcgg gagctcaggg
71821 gtggatgaat gtgtagtcga cgcggcggcc gtggttgacg ctctcgccgg caagggcgcc
71881 agcgcgatcg ttctgcgcgg tttgctcaag gagtcgattt ctaacgcgcc gcatttgctg
71941 gacgcagagg tcggacatgc actccgccgc gccgtgctca gcgacgaaat ctccgaagag
72001 caggctcgcg ccgcgttgga tgccttgcct tatctcatcg acaatcgtta cccgcacagc
72061 ccacgactga tcgaatacac atggcagcta aggcacaacg tcacgttcta cgacgccctt
72121 tacgtcgcac tggccaccgc actggatgtc ccgctgctca cgggcgactc gcggcttgcg
72181 gccgcgccgg gccttccgtg cgaaatcaaa ctcgttcggt gacatccctt tgcgggacgc
72241 caatggcgcc gtcgtagccg ggccagcccg tcgtcagcct tggacagcct ccagcgctgc
72301 attgaacgtc ttgctgggcc gcatcaccgc cgtagtcatg tcgctgtccg gcgcgtagta
72361 gccgccgatg tccaccggtt cgccttgtac ctcggtgagc tctcgcacga tgacgtcttc
72421 gtttttggtc aacacatctg ccagcgaggc gaagtgttcg gccagctgct ggtcgtcggt
72481 ctgcgcggcc agctcttgtg cccagtacat ggcgaggtag aactggctgc cccggttgtc
72541 gagttcaccg gttttgcgcg acggactctt gtcgttgtcc agcagcttgc cgatggcggc
72601 atccagggtc ttacccaaga gtttggcccg ctcgttaccg gtcttgatgc cgatatcctc
72661 gaaaccggcg cccagcgcga ggaactcacc cagagaatcc cagcgcaggt gattctcctc
72721 caccaattgt ttgacgtgct tgggtgccga accgcccgcc cccgtctcgt acattccgcc
72781 gccggccatc agcggaacga cggacagcat cttggcgctg gtgcctaact ccaggatcgg
72841 gaacaggtcg gtgaggtagt cgcgcaggat gttgccggtc gcggcgatgg tgtccagtcc
72901 acggaccagg cgctcgcacg tgtagcgcat ggatcgcact tgcgacatga tctggatgtc
72961 cagaccttcg gtgtcgtgat ctttcaggta tgtcttgacc ttcttgatca gctcgttctc
73021 gtgcgggcgg tacgggtcca gccagaacag caccggcatc ccggagatgc gcgcgcgggt
73081 gacagccagc ttgacccagt cacggatcgg tgcgtccttg acgatgcaca tgcgccagat
73141 gtcgccggct tccacgttct cggtcagcag cacctcgccg gtggcgacat cgacgatgtt
73201 ggcgacgccg tcctcgggaa tctcgaacgt cttgtcgtgc gagccgtact cctcggcctg
73261 ctgggccatc agacccacat tggggacggt gcccatcgtc gtcggatcga actggccatt
73321 tgtcttgcag aagttgatga tctcctgata gatgcgcgag aaggtggact ccgggttgac
73381 cgccttggtg tccttgagct ttccgtcggc gccatacatc ttgccgcccg cgcgaatcat
73441 cgcgggcatc gaggcgtcca cgatcacatc gctcggcgag tggaagttgg agatacctct
73501 ggccgaatcg accatcgcga gctcggggcg gtgttcgtgg caacggtgta ggtcctcgat
73561 gatctcgtcg cgttgcgacg ccggcagcga ctcgatcttg ctgtacagat cggacaagcc
73621 attgttgacg ttgacgccca agtcgtcgaa cagctcctgg tgcttggcga aggcgtcctt
73681 gtagaagatc ctgaccgcgt ggccgaagac gatggggtgg ctgaccttca tcatggtcgc
73741 cttgacgtgc aaggagaaca tcacgccggt ctcgaacgca tcctgcatct gctcttcgta
73801 gaagtcgcac agcgctttct tgctcatgaa catgctgtcg atgacgtcgc cgtcatccag
73861 cggcacctcg ggcttgagca cgatcgtctt gccgctcttg gccagcagtt ccatcctcac
73921 gttgcgcgcg cggtccagtg tcatcgactt ctcgccggcg tagaagtcac cgtgccgcat
73981 gtgcgctacg tgggtgcgtg aggccatcga ccactcgccc atgctgtgcg ggtgcttgcg
74041 cgcgtactcc ttcaccgcct tgggcgcccg acggtccgaa ttgccttggc gcagtaccgg
74101 gttcaccgcg ctgcccaggc atctggcgta gcgctctttg atggccttct cctggtcagt
74161 cttcgggtcc gccgggtagt ctgggaccgc gtaacccttg tcttgcagtt ccttgatggc
74221 ggctaccagc tgtggcaccg aggcgctgat gttcggcagc ttgatgatgt tggtgtcggg
74281 tagctgagtc agccggccca gttcggcgag gttatccggt acccgctgct cctcggtcag
74341 gtaatcgggg aattccgcca ggatgcgtgc cgctacagag atgtcgctgg cctcgatctt
74401 gatgcccgcc ggttcggcaa aggcacgcac aatcggcaga aaggcgtagg tcgccagcag
74461 cggcgcctcg tcggtcagcg tgtaaatgat ggtcggctgt tcggcgctca tggtgttctc
74521 ccggcgtcac tgtcggtcag atgctgaatc actccgcgtt gtagcggcgg ttaccagtat
74581 cgcggattgc gccgcacatg attcgggcgg tgttctgcgc gacgacgatc actttctgtt
74641 tgcccgaagg ccgtcgaggg cgacgtcggt cacctttgcg gccaactcag cgttgtagct
74701 ctgcatcgct tggcagccga ctaggagcgt cttgacttca agcacgtcta cgtccggccg
74761 tacggtgccg gcgcgctggg cggcgcgcaa caggtcggtg agcaggtcca agaaatctgc
74821 ctcggcttcc ggggccgcgc tgctgatttc aatcccgacg ccggccagcg cctcgaccag
74881 gccgcgatcg gtggcgcccc actgcaatac catcgaccgc aggaatgcaa acagcgcgtc
74941 gccgggatgc ttggatttga gcagggcatg tcccttgtcg atgatgcggt gcatccggtc
75001 ggcgatcacc gcctgaaaca gcgcctcctt ggtcgggaaa tgccggtata ccgtgcctgc
75061 gccgactccg gcgcgccgag cgatctcgtc aacgggcacc gatagaccgt cggccgcaaa
75121 ggtttggtag gcaacctcca atacgcgtgc ccggttacgg gccgcgtcgg cacgcacccg
75181 ccggtcagta ggagccaagt cgtacctccg aaagccttga caaagcgggg cgcgcgttcc
75241 gtatagttcg gctaagcgga gcgctcgccc cgcttagtca aagcatagcg aggagccctc
75301 atgaccaaat ggactgccgc cgacattcct gaccagaccg gccggaccgc cgtcatcacg
75361 ggggccaaca ccggacttgg attcgagacc gccgcagcgc ttgccgccca tggtgcacac
75421 gtggtgctgg ctgtgcgcaa cctcgacaag ggcaagcagg cggcggcacg catcaccgag
75481 gccacccccg gcgccgaagt agagcttcag gagcttgacc tgacctcgct ggcgtcggtg
75541 cgcgccgccg cggcacagct gaagtctgac caccagcgca tcgacctgct gatcaacaac
75601 gccggggtga tgtatacacc ccgacagacc acagcagacg gcttcgagat gcagttcggc
75661 accaaccact tgggccattt cgcgttgacc ggcctgttga ttgatcgact gctgcccgtc
75721 gccggttcac gagtggtcac catcagcagc gtcggccatc gcatccgtgc cgcaatccat
75781 ttcgacgacc tccagtggga acgccggtac aggcgggtcg ccgcctacgg ccaagccaag
75841 ctcgccaacc tgctgttcac ttatgaactt cagcgtcggt tagcaccggg cggaaccacc
75901 atcgcggtcg cgtcgcaccc gggagtgtcc aacaccgaag tggtccgcaa catgccacgg
75961 ccgctcgtcg cggtggcggc catactggcg ccgctgatgc aagacgccga actgggggcc
76021 ctgccgacat tgcgtgccgc caccgatccc gcggtgcgcg gcggccagta cttcggaccc
76081 gatggcttcg gtgaaatacg gggctacccg aaggtggtgg cctccagcgc ccagtctcac
76141 gacgagcagc tgcagcgccg cctgtgggct gtgtccgaag agctcaccgg ggtcgtctat
76201 cccgtcggat gagccggact caacggcaac ggttggtcaa cactcgacga tgttgactgc
76261 gacgttgatg gcgagcccgc cggccgaggt ttccttgtac ttggtgtgca tgtccgcgcc
76321 ggtggcgcgc atggtgtcga tgacctggtc gagggtgacg cgatggatgc cgtcgccgcg
76381 caatgccatc cgtgcggcgt tgatggcctt gccggcggaa atcgcgttgc gttcgatgca
76441 ggggatctgc accagcccgg cgatggggtc acaggtcagg ccgaggctgt gttccatggc
76501 gatctcggcg gcgttttcca cttgtcgcgg tgtgccgccg aggatttcag ccaatccggc
76561 ggcggccatg gcggccgcgg agccgacctc gccctgacag ccgacctcgg ctccggagat
76621 cgatgctcgc tccttgaaca acgatccgat ggctccagca gtgagcagga atcgcacggt
76681 gacatcgtcg gggtcccccg cgccggccga cgtgtagtgg attgcgtagt gcaggaccgc
76741 cggcacgatg ccggcggcac cgttggtcgg ggcggtgacg acgcgcccac cggaggcgtt
76801 ctcctcgttg actgccagcg cgaccaggtt gacccagtcc tcagcgaatt ccggcttgcg
76861 agtggggtct tcggcgttca agcggtcata ccacaccttc gctcgccggc gcacccggag
76921 gccgccagga agcaaccctt cgcgagcgat gctccgctgt tcgcactcaa ccatgacgtc
76981 gcgcaggtgc agcagcgcgg cgcgtacctc gttctcggtg cggcaacatg tttcgttgcg
77041 cagcgccgct tcgctaattg acacgtcgag gcggtcacag atgtccagca gttcttgggc
77101 cgacacgtag ggaagggcaa ctgagcatgg atgttggccg ctgttgccgc tggtctgttc
77161 cgtgacgatg aaccctccgc ccaccgaaaa ataagtctcg gtggccaaga cgcggccgtg
77221 tgggcccgcg gcagtgaacg tcattccgtt gggatgcgtt ggcagaacga tgtcgggatg
77281 caggtcgata tcacgctcgg tcagcgggac cggaatgaca ccgccgattc gcgtcacgcc
77341 ggacgctgcg atctcggcga gccggcgttc cttgtgttcg gtggtaatcg tttctggctg
77401 gcagccttcc agccccagca atatcgccga catggtgcca tgaccggctc cggtggccgc
77461 gagcgagccg aacagatcca ctcgcatcgc ctcgaggtca tccaggtggc cccggcggcg
77521 cagcgcaact acgaactggt ttgccgcgcg catcggtccc acggtgtggg aactggacgg
77581 cccgatgccg atggtgaaca ggtcgaagac gctgatggtc atgtccggtg cagttccggg
77641 tagagcggat agcgtgcggc cagccgctgg acctgggcgc gcagcggacc cagctggtcg
77701 tcgttggtgg ccgtcagtgc cgccgcgatg aggtctgcca cggcgcggaa gtcgttgtgg
77761 gagaagccgc gtgcggccag cgccggggtg ccgattcgca ggcccgaggt gatcatcggg
77821 ggacgagggt cgaagggtac cgcgttgcgg ttgacggtga tgtccacggc ggccaaccgg
77881 tcttcggctt gctggccgtc gagttcggcg tcgcgcaggt cgactaggac gaggtgcaca
77941 tcggtgccgc cggttagcac cgcgatgcca cgttcggcga cgtcgggctg ggtcaaccgg
78001 ccggcaagga tgcgcgcgcc gtcgaggcaa cgttgttggc gctgcgcgaa ttcaggttgt
78061 gctgccatct tgaatgcggt ggccttggct gcgatgacat gctcgagcgg cccgccctgc
78121 tgcccaggga agaccgcgga attgatcttc ttggcgatgg ccgggtcatt gcacaagatg
78181 atgccgccgc ggggcccgcc gagcgtcttg tgagtggtgg aggtgacgac gtgggcgtgc
78241 ggcaccgggc tggggtgcac gccagcggcg accaggccgg cgaaatgcgc catatccacc
78301 atgagcacgg cgtcgacttc gtcggcgatg gcgcggaagc gggcgaaatc cagctggcgt
78361 gggtacgccg accagccggc gatgatcatt ttgggccggt gtgtgcgcgc tgcctcggcg
78421 acggcatcca tgtcgaccag gtagtcctct ttggacacct cgtaggcggt ggcgtggtag
78481 agcttgccgg aaaagttgat ccgcatcccg tgggtcaggt gaccgccatg agccagcgac
78541 aaccccagga tggtgtcgcc ggggtttagc agcgcatgca tggtggcggc gttggcggtg
78601 gcccccgaat gtggttgcac gttggcgtat tcggcgccaa agagcgcttt gacgcggtcg
78661 atagccaact gctcgacacc gtcgacgaat tcacagccac cgtagtagcg ccggcccggg
78721 tagccttcgg cgtacttgtt ggtcaagacc gaaccttggg cctgcatcac ggccagcggt
78781 gcatagttct ccgaagcgat catctccaag ccggattctt gacggcgcag ctcgccgtcg
78841 atcagggcgg cgatgtccgg gtcgaaggcg gtcagggagt cgttgagggt gttcatcagc
78901 tcagtccggt ctgttcggcg tactcggggg cggtcaaggg tgttcccgga gcaatcggct
78961 gcccggccaa atgggcatcc ggcggccgcg acatcgtttc ggccacggcg aggtcgccaa
79021 cagttcgatc gtgcggttca gacaagggcc aactccggtt tcgacgagcc cggatcgcgc
79081 cgggctggtt gcgccctccc cgctctgtcc tgaaacctga gagtctgcgg cgtcgcatca
79141 tggcgccgct ctacaccttc ggtcaggcac ggtcggtgcg accgtccctg tctccagagt
79201 tgcctcggcg gtgtggtgct tgggcctgag agattctcgg ggaggagatt gctcctacgg
79261 cgcctcgaca tggaggttct cccacatcgc gtcagcggct gttcgattgt gacggaaagc
79321 aacatacaca ccacgcatgt gttttgtcac cctgcggtcg gtggtagtcg gacggcccaa
79381 tcagacagcg cgggtcatat cacgcgttcg tgcacagttg ggtgtttatc cacaggggtg
79441 cgtttgtcgg cggctggcgg ggcgtggcgg cgatagcatt cgaatatgag ttcgatcacg
79501 gtgtcggtgg acccggtgga cccggtggac ccggtggacc cggtggaccc ggtggacgcc
79561 gtggtcgccg cgggatcaga cgggctcact gtggcccgca tcgagtccga gatcggggcc
79621 ttggagttcc tgaacgaact gcgcactgaa ctcaagagtg gacagtttcg acctcaaccg
79681 gtgcgggaac gcaagatccc caaaccgggc gggttgggca aggtacggcg gctggggatt
79741 cccacagtgg ccgaccgggt cgttcaggcg gcgttgaaac tggtgctaga acccatcttt
79801 gagaccgact tcgagccggt ctcctacggg tttcggcccg cgcgacgcgc gcacgacacg
79861 atcgctgaga ttcacttgtt cggcacccag gagtatcgct gggtgctcga cgctgatatc
79921 aaggcgtgct ttgaccgcat cgaccacgcg gacctgatgg accgggtgcg tcaccggatc
79981 aaagacaagc gggtgttgcg gctggtgaac tggcagcgca ttcggcatcg ctggaattgg
80041 accgacgtcc gccgctggct caccgacccc accgggcggt ggcaccccat cagcgcggac
80101 gggatcaccc tgtttaaccc cgccgcggtg cccattcggc gataccgcta tcggggcaac
80161 acgatcccca ctccctggac tcaggctgtc tgaaccaccc catcggcaga ttccgtgaag
80221 agccagatac ggtgaaagtc gcacgtccgg ttcgaagggc ggccacggga aacggacccg
80281 cagcaacgcg ggcaccgcac ccatggtcga cccaactgcc acgcacccgg tgaccggtgc
80341 gaagtccacc atatcgacca gtgggcaacc ggcggctcaa ccgatatcga caaactcacc
80401 ttcacctgca cacccaacca caagctagtc gggaaaggct ggcagacaag gaaacggtcc
80461 gacggccaaa cggaatggat cccgccaccc cacctcgacc gcggtgccca caccaacgac
80521 taccaccacc ccgaacgcct cttcgaccac tagcgggccg cgccctgacc acaaaacgtc
80581 aagaccaggc cccacaagtg cgccacgttg gtagcctctg ggaatgctct tcgcggccct
80641 gcgtgacatg caatggagaa agcgccgcct ggtcatcacg atcatcagca ccgggctgat
80701 cttcgggatg acgcttgttt tgaccggact cgcgaacggc ttccgggtgg aggcccggca
80761 caccgtcgat tccatgggtg tcgatgtatt cgtcgtcaga tccggcgctg ctggaccttt
80821 tctgggttca ataccgtttc ccgatgttga cctggcccga gtggccgctg aacccggtgt
80881 catggccgcg gccccgttgg gcagcgtggg gacgatcatg aaagaaggca cgtcgacgcg
80941 aaacgtcacg gtcttcggcg cgcccgagca cggacctggc atgccacggg tctcagaggg
81001 tcggtcaccg tcgaaaccgg acgaagtcgc ggcatcgagc acgatgggcc gacacctcgg
81061 tgacactgtc gaggtcggcg cgcgcagatt gcgggtcgtt ggcattgtgc cgaattccac
81121 cgcgctggcc aagatcccca atgtcttcct cacgaccgag ggcttacaga aattggcgta
81181 caacgggcag ccgaatatca cgtccatcgg gatcataggt atgccccgac agctgccgga
81241 gggttaccag actttcgatc gggtgggcgc tgtcaatgat ttggtgcgcc cattgaaggt
81301 cgcagtgaat tcgatctcga tcgtggctgt tttgctgtgg attgtggcgg tgctgatcgt
81361 cggctcggtg gtgtaccttt cggctcttga gcggctacgt gacttcgcgg tgttcaaggc
81421 gattggcacg ccaacgcgct cgattatggc cgggctcgca ttacaggcgc tggtcattgc
81481 gttgcttgcg gcggtggtgg gcgtcgtcct ggcgcaggtg ttggcaccac tgtttccgat
81541 gattgtcgcg gtacccgtcg gtgcttacct ggcgctaccg gtggccgcga tcgtcatcgg
81601 tctgttcgct agtgttgccg gattgaagcg cgtggtgacg gtcgatcccg cgcaggcgtt
81661 cggaggtccc tagcggtggg cgatctcagc attcagaacc tcgtcgttga gtactacagc
81721 ggtggatacg cgcttaggcc gatcaacggt ttgaacctcg acgtggcagc cgggtcgttg
81781 gtgatgctgc tcggacccag cggctgcggc aagacgacac tgctttcctg tctgggcggc
81841 attctgcgcc cgaagtctgg ggcgatcaag ttcgacgaag tcgacatcac gacgctacaa
81901 ggcgccgagc tggcgaacta ccggcgtaac aaggtcggca tcgtgttcca ggcgttcaat
81961 ctggtgccca gcctgaccgc tgtcgagaac gtgatggtgc cgttacgctc ggccgggatg
82021 tcacgcaggg cgtcgcgtag gcgtgccgaa gaactgctgg cgcgcgtcaa tctcgcggaa
82081 cgaatgaatc atcgacccgg tgatctgagc ggaggtcagc agcaacgagt cgcggtggca
82141 cgcgcgattg cgctggatcc gccactgatc ctcgctgacg aaccgaccgc acacctggat
82201 ttcatccagg tggaggaggt gctgcggttg atccgcgaac tggccgatgg cgagcgtgtg
82261 gtcgtggtcg caacccacga cagcaggatg ttgccgatgg ccgatcgcgt cgttgagctg
82321 acacccgatt tcgcggagac aaatcggcca cctgaaaccg tacatcttca ggccggcgag
82381 gtgctgttcg agcagagcac gatgggcgac ctgatctacg tggtgtcgga gggcgagttt
82441 gagattgtgc acgaattggc cgacggcggt gaggaattgg tcaaggttgc cgggccgggg
82501 gattacttcg gcgagatagg cgtgctgttt cacctgccgc gctcggcgac cgtgcgtgcc
82561 cgcagcgacg cgacggccgt cggctatacc gtgcaggcgt ttcgtgagcg gctcggcgtg
82621 gggggtctgc gcgatctgat cgagcatcgt gcgcttgcca acgactaacc cggcttggcc
82681 ggaactagcc actgccgggg cagcggtggc ggttcacacc gcgtgcgcgt ttggaggtcc
82741 ctgagcgatg ggcgatctga gcattagcca ggtgtcggcg cgtccgggac ggatcgggat
82801 tcgcgctagg caaatgttcg acggataccg gtttcagcgt ggtcccgtgc tggtcgtggt
82861 cgaggatggt cggatcagcg cggtcgattt tgctggctcc gcctgccccg atatgaacct
82921 ggttgatctg ggtgaatcga ctttgttgcc gggtctggtg gatgcgcatg cgcatttgtg
82981 ctgggacccc gacggtaggc cagaggattt ggccggcgac ccccatgcgg tgctggtggg
83041 acgggcgcga cggcacgccg cggccgcgtt gcgctccggg atcaccacga ttcgcgatct
83101 cggcgaccgt gactatgcgg ccttggcgct gcgggaggag tatcggcaga aaacgacggt
83161 ggggccggaa ctggtggttt ctgggccacc attgactcgc agcggcgggc attgctggtt
83221 cctcggcggc gtggccgata gcgtcgagga gctggttgat gcggtgcagg agcgggccgc
83281 gcggggagcg gattggatca aggtgatggc cacgggcgga ttcgttacca cagcatccga
83341 tccgtggcag ccgcagtacg gcagcggcca actggccgcg gtggtggcgg ccgccgagca
83401 ggtaggtcta ccggtgaccg cacatgcaca tgccaccgca gggatcgccg cggcggtcgc
83461 cgcgggtgtt gacggcatcg agcactgcac gttcttgagc gaaggcagcg ccgccgccag
83521 cccggatgtt gttgaagcga ttgttgccca aggtgtgtgg tgcggtatga cgattccccg
83581 ggtgtatccg gagatgccgg agaaccttgt cgcggttgtg caggatggat ggcgaaacat
83641 ccgccggctc atcgacgccg gtgcgcgtgt cgccctgtcc accgacgctg gagtcgcccc
83701 gggcagacgc catgacgtgc tccccgacga tttggtgtat ctgtctcgac acgggttcac
83761 cagcacagag gtgctgaccg gcgccaccgc agcggccgct gccagctgtg ggctcggcca
83821 ccgcaagggt cgcatcgcgc cgggctacga cgctgatctg ctggctgttg cggcaggtgt
83881 ggaccatgac cccgccggac tctgcgacgt caaagccgtc tggcgcagcg gaacccaggt
83941 accgctacaa gcatccgctg tgggctacaa caccccgtca taaccccgtc ataaaatgca
84001 ggacagcatc ttcaatctgt tgaccgagga acagcttcgg ggtcgcaaca cgctcaagtg
84061 gaactatttc gggcccgatg tagtgccact gtggctggcg gagatggact ttcccaccgc
84121 accggctgtg ctcgacgggg tgcgggcgtg cgtcgacaac gaggagttcg gctacccgcc
84181 gttgggcgag gacagcctgc cgagggcgac ggccgattgg tgccgacaac gctacggttg
84241 gtgcccccga ccggactggg tccgcgtcgt gccggatgtc ctgaagggga tggaagtcgt
84301 cgtcgaattc cttacccggc cggagagtcc ggtcgcgttg ccggttccgg cttacatgcc
84361 gtttttcgac gtcctgcacg tcaccggccg ccaacgagtg gaagtcccaa tggtgcagca
84421 agactcggga cgctacctgc tggacctgga cgctctgcag gccgcgttcg tccgcggtgc
84481 cggatcggtg attatctgca atccgaataa cccactgggt acggcgttca ccgaagccga
84541 gctacgtgcg attgtggata tcgcggcccg ccacggcgcc cgggtgatcg cggatgagat
84601 ctgggcaccg gtggtctacg gatcgcgcca tgtcgccgcc gcttcggtgt cggaggcggc
84661 ggctgaagtc gtggtcacgt tggtgtcggc gtccaaaggc tggaacttgc cgggtctgat
84721 gtgcgctcag gtgatcctgt ctaaccgccg tgacgcccac gactgggacc ggatcaacat
84781 gttgcaccgc atgggcgcat caacggtcgg tatccgcgcg aacatcgccg cctaccatca
84841 tggcgaatct tggttggacg agctgctccc ttatctgcgg gcgaaccgtg atcatctggc
84901 acgggcgctg ccggagttag ctcccggggt agaggtcaac gctccggacg gtacctacct
84961 gtcgtgggtg gatttccgtg cgctggctct gccgtctgaa ccggcggaat acctgctctc
85021 gaaggcgaag gtggcgctgt cgcctggcat tccgttcggc gccgcggtgg gctcgggatt
85081 tgcgcggctg aacttcgcca ccacccgcgc aatactggat cgggcgatcg aggctatcgc
85141 ggccgccctg cgcgacatca tcgattaagc caaccagtag attcacaacg ctgcggcgtg
85201 ttgggtcagg ctgaagaaga tgtaggcgag gcagatcagg aagttcagtg ccacgagaac
85261 caaacccaga cagattagtg aatgcgtggc tcggcgttgt aggcggtgga atttcgcgac
85321 gcgcttctca tggttcagct gggtcacgat cagtgcgaac ttgacgtcgg tccattcttc
85381 gtcggcggcg ggagcgccca acagcatttc ctgaaggcgc ttcggcgggg cttcgacgcc
85441 gacccgcgcg aagtgctggc tcagccgccg ggcttgcctg cggccaagaa tctgaccccg
85501 caccggtggc tgatgcgaga gcttccttcg ttcgtccccc cagtggttgg acggggtcgt
85561 cacagcgggc attctaagtc ccgcgggcca caaaaggcag tgccgcggaa cttcttggcc
85621 caaacgggca cccggctacg tgcgcaccgc gaccgtcgac aactggtcgg cgagccggtc
85681 cggggaatcc accatcgaga acgtccgtgc tccctcgatt acctcgaaac gggcgcgcgg
85741 gatggtcgcg gcgagccgtt gaccgttctc gagtgcgaag aacacgtcat ccgccgacca
85801 cgcgatgagc gccggcttgt cgaattcagg cagccgggcg gcgactgcgg tggtgacttc
85861 ggtgcgcagc gatagcgaga gctgacgcag gtcttcggcg atggccgggt tggatagcgc
85921 cggacgaacc caggcccggg tgagatggtc gatgttgtgg tgcgacaaac cggcatacgc
85981 gcggttacgc gcggccggtg cccgcatcac ctggatcgcg gcccggaaca gggtggccga
86041 tttcgcggcc aggatcaccg gtttgaggat cggcggcgga aagtgttcga acgcatcgca
86101 actagtgagg accagggcac cgagccgttc gggatagtgg accgcgacga gctgggtgac
86161 gaccccgccg gtgtcgttgc cgaccagcac cacgtccttg agctcgagcg cggcaaggac
86221 gtcggcgacg atgccggcaa ccccgccgat ggtctggtcg gcgccggggc gtagcggctt
86281 aggatgcgca cccagcggcc aggtgggggc gatgcagcgc aggccacgac cggcgagtcg
86341 ctcactgacc cgtcgccata gttgaccgcc catcatgtac ccgtgcacga acacgacagg
86401 cctgccagtt tcgggtccgg ttgcttcgta atgaatagtt ccggcactaa tgtcgatcgt
86461 cgacatggat gcccaccctt cgaggtacat ttacaagcag actgccggta acttaccaac
86521 agattgtatg gaaatcaaga gacgcaccca ggaggaacgc tccgcggcga cccgcgaggc
86581 gctgatcacc ggggcccgca agctgtgggg gttacggggt tatgcggagg tggggacgcc
86641 ggaaatcgcg accgaggcgg gggtcacgcg gggggcgatg taccaccaat tcgccgataa
86701 agcagcacta ttccgcgatg tggtggaggt cgtggagcaa gacgtgatgg cccggatggc
86761 caccttggtc gccgcctcgg gggcggcgac gccggccgat gcaatccggg cagcggtcga
86821 tgcctggctc gaggtatctg gtgatccgga ggtgcgtcag ctgatcctgc tggatgcgcc
86881 cgtcgtgctg ggctgggcgg gtttccgcga cgtcgcccag cgatacagcc tgggcatgac
86941 cgaacagttg atcaccgagg cgatccgggc cggccagttg gctcgtcaac cggtgcggcc
87001 gctggcccag gtgctcattg gcgcgctcga cgaggcggcg atgttcatcg ccaccgccga
87061 cgaccccaag cgcgcccgtc gggagaccag acaggtgctg cgccggctca tcgacgggat
87121 gcttaacggc tagcgctggg cgcggcctcg gcaaaatggc ttgcggaccg ggatctgagt
87181 tccagaactg ggcgcaggac tggctggtca ccacttggcg gcgaggcgtg tccattccgc
87241 tgccaggtcg cggtcccggt ggaagccgcg cagggtaatc agctcgatag ctttgcgcgc
87301 atcttggata tcttgaggcg atgcggcgtc cacgagcgca cgtagatcac tgcgatcctg
87361 gggtcgccga tcatcatctc tcgcaagaag tttcatcgcg atcagatgcg ccgttgtggc
87421 caccggagcg actagatcgg gcaagatctc gatctcctcg gcagcctccg caatctccgg
87481 ttcgatgcca cagctcgcga aaaggaggtc caccacaaca ttcgcggcag tgtctgcggt
87541 tgctccgaga cggaccgctg ccaaccgtct ggccgcgtcc tgctctaccg acgccaggag
87601 atggtactgc tgggtaagaa gttgacggac taaagattcc gcggcatcgt cgtttgccac
87661 cgcgacaaca atgtccacgt cacgggtgaa acgtggttcg gatcgcgcag acaccgcgaa
87721 accaccaacc agcgcccacc gctgacgcaa tccggtcagg tccttggcga ccctacggag
87781 tgtcgactcc acagcgttca tgtgaaccgt gtggacgtcg ggcctgcgct gtcaccctcc
87841 tccgccccgg gacgcgtcat cctccacgcg tcgatagctg cttcaatttc aacaacgtcc
87901 gcattgggcc gttcacgacc cagcctcatg cgctgcatct gctcgccaac ctcgtacatg
87961 tccagagcga gcctcagctt ctgcgcagcg acggaaactg ccacactcaa agcctactgg
88021 gcgcacgtgt ggcaacgagt cgatccacac gaaatgccgc cgttgggccg cggactagcc
88081 gaattttccg ggtggtgaca cagcccacat ttggcatggg actttcggcc ctgtccgcgt
88141 ccgtgtcggc cagacaagct ttgggcattg gccacaatcg ggccacaatc gaaagccgag
88201 caggtggaac cgaaacgcag tcgcctcgtc gtatgtgcac ccgagccatc gcacgcgcgg
88261 gaattcccgg atgtcgccgt attctccggc ggccgggcta acgcatccca ggccgaacgg
88321 ttggctcgtg ccgtgggtcg cgtgttggcc gatcggggcg tcaccggggg tgctcgggtg
88381 cggctgacca tggcgaactg cgccgatggg ccgacgctgg tgcagataaa cctgcaggta
88441 ggtgacaccc cattaagggc gcaggccgcc accgcgggca tcgatgatct gcgacccgca
88501 ctgatcagac tggatcgaca gatcgtgcgg gcgtcggcac agtggtgccc ccggccttgg
88561 ccggatcggc cccgccggcg attgaccacg ccggccgagg cgctagtcac ccgccgcaaa
88621 ccggtcgtgc taaggcgcgc aaccccgttg caggcgattg ccgctatgga cgccatggac
88681 tacgacgtgc atttgttcac cgacgccgag acgggggagg acgctgtggt ctatcgggct
88741 ggaccgtcgg ggctgcggct ggcccgccag caccacgtat ttcccccagg atggtcacgt
88801 tgtcgcgccc cagccgggcc gccggtgccg ctgattgtga attcgcgtcc gacaccggtt
88861 ctcacggagg ccgccgcggt ggaccgggcg cgcgaacatg gactgccatt cctgtttttc
88921 accgaccagg ccaccggccg cggccagctg ctctactccc gctacgacgg caacctcggg
88981 ttgatcaccc cgaccggtga cggcgttgcc gacggtctgg catgagcccg ggctcgcggc
89041 gcgccagccc gcaaagcgcc cgggaggtgg tcgagctcga ccgtgacgag gcgatgcggt
89101 tgctggccag cgttgaccat gggcgtgtgg tgttcacccg cgcggcgctg ccggcgatcc
89161 gtccagtcaa tcacctcgtg gtcgacggtc gggtgatcgg gcgcacccgc ctgacggcca
89221 aggtgtccgt tgcggtgcga tcgagcgccg atgccggtgt cgtggtcgcc tacgaagccg
89281 acgaccttga tccgcggcgt cggacggggt ggagtgtggt ggtgacggga ctggcgaccg
89341 aggtcagcga tcccgagcag gttgcccgct accagcggct gctacacccg tgggtgaaca
89401 tggcgatgga caccgtggtc gcgatcgaac ccgagatcgt caccggcatc cgcatcgttg
89461 ctgactcgcg tacgccgtag ccgattggcc gcgggcggcc cgcacgcatc cgcactatct
89521 gataaattct tcaactcgtc aaccgatgta acgctgaagc tctcaggaga cgcggtggag
89581 tccgaaccgc tgtacaagct caaggcggag ttcttcaaaa cccttgcgca tccggcgcgg
89641 atcaggattt tggagctgct ggtcgagcgg gaccgttcgg tcggtgagtt gctgtcctcg
89701 gacgtcggcc tggagtcgtc gaacctgtcc cagcagctgg gtgtgctacg ccgggcgggt
89761 gttgtcgcgg cacgtcgtga cggcaacgcg atgatctatt cgattgccgc acccgatatc
89821 gccgagctgc tggcggtggc acgcaaggtg ctggccaggg tgctcagcga ccgggtggcg
89881 gtgctagagg acctccgcgc cggcggctcg gccacgtaac gccatgggtt gggttgccaa
89941 gattttccgt gttggccggg tggtcgagcc cgcggccccc ttaccggcgg cgatagccga
90001 accacccgcc ggggtacggg gttcgctgca gatccgacat gttgacgcgg gttcgtgcaa
90061 cgggtgtgag gtggagattt cgggcgcctt tggcccggtg tatgacgcgg agcggttcgg
90121 ggcgcggctg gtcgcctcgc cccgacacgc cgatgcgttg ttggtgaccg gcgtggtcac
90181 gcacaacatg gccggcccac tgcgcaagac cctggaggcc acgccgcgcc cgcgggtggt
90241 aatcgcgtgc ggggattgcg cgctgaaccg gggggtgttc gccgacgcct acggcgtggt
90301 cggtgcggtc ggcgaggtgg tacccgtcga cgtcgagatc gccggctgcc cgccgacacc
90361 cgcggccatc atggcggcgc tgcgatcggt gaccgggaaa tgaccgctgc accgacggcc
90421 ggcggggtcg tcacttcggg cgtgggcgtt gccggggtcg gcgtggggtt gctgggcatg
90481 tttggaccgg tgcgtgtagt gcacgtcggt tggctgcttc cgctgtccgg cgtgcacatc
90541 gagctcgacc ggttgggcgg attcttcatg gcgctcacgg gcgcggtagc ggctccggtc
90601 ggttgttacc tgatcggcta cgtgcgccgt gaacacctcg gtcgggtccc gatggcggtg
90661 gtgccgctgt tcgtcgcggc gatgctgttg gtgccggccg cgggctcggt gacgacgttt
90721 ctgctggcgt gggagctgat ggcgatcgcg tcgctgatcc tggtgctctc cgagcacgcc
90781 cgcccgcagg tccgctcggc gggcctgtgg tacgccgtga tgactcagct gggattcatc
90841 gcaatcctgg tcgggctggt ggtgttggcg gcggccgggg gttccgaccg gttcgccggc
90901 ctcggggcag tctgcgacgg ggtccgcgcc gccgtattta tgctcacgct ggtcgggttt
90961 ggttcgaagg cgggcctggt gccactgcac gcctggctgc cgcgggccca cccggaggcg
91021 ccgagcccgg tgtcggcgtt gatgagcgcg gcgatggtca acctgggcat ctacggcatc
91081 gtccgtttcg atctgcagct gctggggccg ggcccacgct ggtgggggct tgcgctgctg
91141 gccgtgggcg gcacgtccgc gctgtatggg gtgctgcagg cttcggtggc cgccgatctc
91201 aaacggctgc tggcctattc gacgaccgag aacatgggcc tgatcacgct ggcgctcggt
91261 gcggcaacac ttttcgcgga taccggagcc tacgggccgg cgtcgatcgc cgccgccgca
91321 gcgatgctgc acatgattgc gcacgcggcg tttaagagcc tcgccttcat ggcggccgga
91381 tctgtgctgg ccgcgaccgg gctgcgcgac ctggacctgc tcggcgggct ggcccgccga
91441 atgccggcga ccaccgtctt tttcggggtg gccgcactgg gcgcatgtgg tctgccgttg
91501 ggcgccgggt ttgtcagtga gtggctgctg gtccagtcgt tgatccacgc tgcccccgga
91561 cacgacccca tcgtggcgct gacgacaccg ctggcggtcg gcgtggtcgc actggccacc
91621 ggtctgagcg tggcggcgat gaccaaggcc ttcgggatcg ggtttctcgc ccgtccccgc
91681 tccacccaag ccgaagcggc gcgtgaggcg ccggccagca tgcgcgccgg catggcgatc
91741 gcggcgggcg cctgcctggt gctggcggtg gcaccgctgc tggtcgcacc catggtgcgg
91801 cgggccgccg cgacgctgcc ggccgctcag gcggtcaagt tcaccggtct gggcgccgtg
91861 gtgcggctgc ccgcgatgtc cgggtcgatc gcgcccggcg tgatcgccgc cgctgtgctc
91921 gccgcggcgt tggcggtagc cgtcctcgcg cggtggcgtt tccgccggcg cccggcgccg
91981 gccaggttgc cgctgtgggc ttgcggcgcg gccgatctca ccgtgcgcat gcaatacacg
92041 gccacgtcgt tcgccgagcc gctgcagcgg gtcttcggcg acgtgctgcg cccggacacc
92101 gacatcgagg tcacccacac cgccgagtcg cgctatatgg ccgagcggat cacctaccgg
92161 accgcggtcg ccgacgcgat cgaacagcgc ctctatactc cggtggtcgg ggcggtggcc
92221 gccatggccg agctgctgcg ccgtgcccac accggcagcg tgcaccgcta cctggcctac
92281 ggcgcgctgg gcgtactgat cgtgctggtg gtcgcgaggt gaacgtgatg tcctacctag
92341 cgggcgccgc gcaaatcggc ggggtcatgg tgggtgcgcc gctggtcatc ggtatgacgc
92401 ggcaggtacg ggcacgctgg gaaggccggg ccggcgccgg cctgctgcaa ccgtggcgtg
92461 atctgctcaa acagcttggc aagcaacaga tcacaccggc ggggacgacg atcgtgttcg
92521 ccgccgcgcc ggtgatcgtc gccgggacaa cgcttttgat cgccgcgatc gcacctctgg
92581 tggccaccgg gtcacccctg gaccccagcg ccgacttgtt tgccgtggtc gggctgctat
92641 tcctgggcac cgtcgcactg accctggccg gcatcgacac cggcacctct ttcggcggca
92701 tgggcgccag ccgcgagatc accatcgccg cactggtcga accaacgatc ctgctggcgg
92761 tgttcgcgct gtccatcccc gccggatcgg ccaatctcgg tgcgctggtg gcgagtacga
92821 tcgaccaccc gggccacgtg gtgtcgctgg ccggcgtact ggccttcgtg gcgttggtga
92881 ttgtcatcgt cgccgagacc gggcggctgc cggtggacaa cccggccacc cacctggaat
92941 tgacgatggt gcacgaggcc atggtcctcg agtacgccgg cccacggctg gcgctggtcg
93001 aatgggcggc cgggatgcgg ctcacggtgc tgctggcact gctggcgaat ctgttcctgc
93061 cgtgggggat cgccggcgcc gcgcccaccg cgctcgacgt gttgaccggc gtggtggcgg
93121 tggcggccaa ggtcgcgatt ctcgcggtgc tgctggcgac gttcgaggtg ttcctcgcca
93181 aactgcgatt gttccgggta cccgaactgc tggccggctc gtttctgctg gccttgctcg
93241 cggtcaccgc cgccaacttc ttcacggtgg gggcgtgagg ggccagcgat gagtaacgcc
93301 aacttctcga tcctggtcga cttcgccgcg ggtgggctgg tgttggcgtc ggtgctgatt
93361 gtctggcgcc gcgacctgcg ggccattgtg cggctgctgg cctggcaggg tgctgcgctg
93421 gccgcgatcc cgctactgcg cggcatccgc gacaacgacc gtgcgctgat cgcggtgggc
93481 atcgccgtgt tggcgctgcg cgcgctggtg ttgccctggc tgctggcccg cgcggtgggc
93541 gccgaagcgg ccgcgcagcg ggaggccacc ccgttggtca acaccgccag ctcgctgctg
93601 attaccgccg gactgaccct caccgcgttc gcgatcaccc agccggtggt caacctggaa
93661 ccgggcgtca ccatcaacgc ggtgccggcc gcgttcgcgg tggtgctgat cgcgctgttc
93721 gtgatgacca cgcggctgca cgcggtctcg caggccgccg gattcctgat gctagacaac
93781 gggatcgcgg cgaccgcatt cctgctcacc gccggggtgc cgctgatcgt cgaacttggt
93841 gcctcgctgg acgtgctgtt cgcggtcatc gtgatcggcg tgttgaccgg ccggctgcgc
93901 cgcattttcg gcgatgccga cctggacaag ctgcgggagt tgcgggattg atgaccggtt
93961 tgctgcttgc cgcgatcctc gcaccgctcg ccgcgtcaat cgcctccttg atcaccgggt
94021 ggcgacgcac gacggcgacg ctcaccgcgc tgtccgccac gacggtgctg gcctgcgctg
94081 tggcgatggg gttttggatg gggtcggggg cgcagttcgg gctgggcggt ctgctgcgcg
94141 ccgatgcgct gacggtggtc atgctcgtcg tcatcgggat cgtcggcaca ctggccaccg
94201 cggcgagcat cggctacatc gacaccgagc tggcacacgg gcatatcgac ggacgtagcg
94261 ctcggctgta tggggtgctg accccggcgt ttctttgcgc gatggttctg gcggtgtgcg
94321 ccaacaacat cggcgtcatt tgggtagcga tcgaggccac cacggtgatc accgcgtttc
94381 tggtggggca tcgccgcacc cgcaccgcgc tggaagcgac ctggaaatac gtggtgatct
94441 gttcggtcgg gatcgccgtc gccttcttgg gtaccgtgct gctgtatttc gccgcgcggg
94501 attccggtgc cgctgctgcc ggcgcgctga acctcgatat cctggccgaa cacgccgccg
94561 gcctagaccc cggggtcgct cgactggccg gcgggttgct gctcatcggt tatggcgcca
94621 aggcgggcct cttcccgttt cacacctggc tggcggacgc gcacagccaa gcccccgcac
94681 cggtgtccgc actgatgagc ggcgtgctgc tggcggtggc gttctcggtg ctgatccgat
94741 tgcggccgat cctcgacgcg gtcagcgggc ccgcctacct gcgcaacggg ctgctcgtgg
94801 tcgggttggc gacgctgctg gtggcggtgc tgatgctgac cgtgaccggc gacgtcaagc
94861 ggatgctggc ctactcgtcg atggagcaca tgggcctgat cgcgatcgcc gcggccgccg
94921 gcacgacatt ggcgatcgcc gcgctgctgc tgcacgtgct cgcccacggg atcggcaaga
94981 ccgtgctgtt tctggcgggc ggtcagctgc aggccgcaca cgactccacc gccatcgccg
95041 atatcaccgg cgtgatgcga cggtcgcggc tgatcggcgt gtcgtttgcc gtcggcctga
95101 tcgtcctgct tggcttgccg ccgttcgcga tgttcgccag cgagctggcg atcgcgcgct
95161 cattggccaa cgagcggctg gcctgggtgc tgggtgcggc gctgctgctg atcgccatcg
95221 gtttcacggc tctggcacgc aattccggac gcatgctgct cggcaccccg gcggcgggcg
95281 cgccggcgat caccgtgccg gccaccgcgg cggcggcgtt gatggtgggc atcgtcgtct
95341 cggcggccct cggcatcacc gcgggcccac tcgccgacct gcttggcatc gccgccagca
95401 acgtgggtct accgtgatga gtgccagctg gctgcgccac cgggtatccg agcgtggact
95461 gatagcgacg gccgaacaac tctgggccga ttcgtttcgc ctggccctgg tcgctgccca
95521 cgacgacggc gacagtctgc gtgtcgtgta ccttttcttg gcgggctatc cagatcgccg
95581 cgtcgagttg gaatacgttg tgccggcgga taatccagag atcagatcgt tggcgtacct
95641 gtcctttccg gctggccggt tcgagcgcga aatggcggac ctgtacggaa ttcgcccggt
95701 cggccatccc aaaccccgcc gactggtacg gcacgcgcat tggcccgact ggcatcccat
95761 gcgcaccgac gccgggcccg cgcccgaatt cactgatacg ggggccttcc cgttcctcgc
95821 cgtcgaagga cccggcgtgt acgagattcc ggtcgggccg gtgcacgccg gcctcatcga
95881 acccggtcac ttccggtttt ctgtcgcggg cgagacgatc gtgcggctga aggcgcggct
95941 gtggtttgtg caccgtggca tcgagaaact cttccacggc cgccccgcca cggccgcggt
96001 cgatctcgcc gaacgcatca gcggcgacac gtcggcagcg cacgcgctcg cgcacagcct
96061 ggcgatcgaa gacgctctcg gcatcgagct gccccacgag gtccaccggc tgcgggccct
96121 gatcgtcgaa ctcgaacggc tctacaacca cgccgccgac ctgggtgcct tggccaacga
96181 cgtcggctac tcgctggcca acgctcacgc ccaacgcatc cgcgaaaatc tgttgcggcg
96241 caatgccgca gtcaccggtc accggctact gcgcggcgcc atccgcgcgg gcggggttgc
96301 gctgcgtgcg ctgcccgata ccgacgagct tgcagcgctc gccgtcgatc tcgccgaggt
96361 cgccaccctg acgctggcca actcggtggt ctacgaccgc ttcgccggca ccgccgtgct
96421 gcaccccgac gacgccagcg ccctgggctg cctgggctat gttgcccgcg ccagcggact
96481 gcgcagcgac gcccgggtcg aacaccccac catagtgctg cccatcaccg agatcggcgc
96541 gcctgacggc gacgtcttgg ctcgctacac cgtgcggcgc gacgaattcg ccgcgtctgc
96601 cgctcttgct caacacattg tcgaatcaca caccggtcca atagaatacg ccgctacact
96661 gcacccggtg ggcgcgccca gcagcggtat cggcatcgtc gaaggctggc gcggcactat
96721 cgtgcaccgc gtcgaaattg acgtcgatgg ccgcatcacc cgggcgaaag tcgtcgatcc
96781 gtcctggttc aactggcccg cactgccggt ggcgatggcc gacaccatcg tccccgactt
96841 cccgttggcc aacaaaagct tcaaccagtc ctacgcgggc aacgacctct aaccgtgagc
96901 gcgcccagtt gtacggccct agcggcgtgt cggtgtacaa acacgcaccc tcgcgggttc
96961 ggttgcgcca aactagaagt accgtggtca agggacgttc ggggagcctg tcgtggcgtc
97021 gagtgcgcac cggtgacctc ggtctggctg tttggggtgg acgcgaggag taccgggcgg
97081 tcaaaccggg cacaccaggg atacaaccga agggagacat gatgactgtg accgttgtcg
97141 atgctggacc cggccgggtg agccgttcgg tggaggtggc cgcgccggcg gccgagttgt
97201 tcgccatcgt tgctgatccc cggcgccacc gcgaactgga cggatcgggc acggttcgcg
97261 gcaacatcaa ggtaccggcg aaattagttg tcgggtcgaa gttttcgacg aagatgaagt
97321 tgttcggcct accgtatcgc atcaccagca gggtgaccgc gctcaaaccg aacgaattgg
97381 tcgagtggag ccacccgtta ggccatcggt ggagatggga attcgaatcg ctgtcaccga
97441 cactgacccg cgtcaccgag acattcgact accacgccgc cggtgcgatc aagaacggcc
97501 tgaagttcta cgagatgacg ggtttcgcga agtccaatgc ggcgggaatc gaggccacgt
97561 tggccaagct gagcgatcag tacgcccgcg gtagggcatg acgccatggg ggcgtgtcgg
97621 tgtaccgaca cgctcgctca cgggttcggt tgcaccaaga aaagatgtac cagatcacct
97681 gcctgaatag gatttttggc ccgacgtagc ttcgggctag cgcgagcgac gactccgccg
97741 tcgagcagga tgtcaccgtg gatcaaccgt ggaacgccaa catccactac gacgctctgc
97801 tggatgccat ggtgccgctc ggtacccagt gcgtgctcga cgtcgggtgc ggcgacgggt
97861 tgctggctgc ccggctggct cggcgcatac cctacgtcac ggcagtggac atcgatgcgc
97921 ccgtcctgcg acgtgcgcag acacggttcg ccaacgcgcc gatccgctgg ctgcatgccg
97981 acatcatgac ggctgagctg cccaacgcgg gcttcgacgc cgtggtctcc aatgccgccc
98041 tgcaccacat cgaggacact cggacggcgc tgagccggct cggcgggctg gtaactcccg
98101 gtgggacgct ggccgtggtc accttcgtga cgccctcgct gcgaaacggc ttatggcact
98161 tgacaagctg ggttgcctgc ggcatggcca atcgcgtcaa gggcaagtgg gaacattccg
98221 ctccgatcaa gtggccgccc ccgcagacgt tgcatgagct acgcagccac gttcgcgccc
98281 tgctgcccgg ggcgtgtatc cgtcggctgc tgtacggccg ggtgctcgtt acgtggcgcg
98341 cacccgtcta atcgggagaa cccaatggcg gcggccgata tgaccaagtg cgcgttagct
98401 tgcgagattg gctgcccgca tccaatgatc ggcggatacg ggtcgcaaac cacctcagac
98461 cggcagctaa ggagcgcaag tggccaagaa ccaaaaccgc atccgcaacc ggtgggagtt
98521 gatcacctgt ggtctcgggg gacacgtcac ctacgcgccg gacgacgcgg cacttgctgc
98581 gcggctgcgc gccagcaccg ggctgggcga agtatggcgc tgcttgcgct gcggcgattt
98641 cgcgctcggt gggccgcagg ggcgtggtgc tcccgaggat gcgccgttga ttatgcgcgg
98701 caaggcgtta cgtcaggcca tcatcattcg cgcgctcggg gtcgaacggc tagtccgggc
98761 gttggtgttg gcgctggccg cgtgggcggt gtgggagttt cgcggtgcgc ggggagctat
98821 ccaggcgacc ctggataggg acttgccggt cctgcgtgcg gccggattca aggtcgatca
98881 aatgacggtg atccacgctc tggagaaagc gttggccgcc aaaccgtcga cgttggccct
98941 gatcacgggc atgctggcgg catacgcagt gctgcaggcc gtcgaggggg tcggtttgtg
99001 gctgctgaag cgctggggcg agtacttcgc ggtggtggcc acctcaattt tcctgccgtt
99061 ggaggttcac gacctggcca agggcatcac gacgactcgg gtcgtgacct tcagcatcaa
99121 tgtcgccgcc gttgtctacc tgctgatttc taagcggttg ttcggtgtgc gcggcgggcg
99181 caaggcttat gacgtcgaac ggcgcggcga gcagctgctc gacctcgagc gcgccgcgat
99241 gctcacctga ccagccaaaa tcccacctgt gcggggcctg cgggttgtgt caaaggtcac
99301 cagcgccttt ttcgcactgt ttactccggc gcggcgtgcc cgtaaagccg cccgggtgaa
99361 cttggatcag gtggcgcaat gtcgccggac cgacgaagga ccgacgctgt gtcaacactg
99421 ccaacctggg tcagccagag ctctaccgac cgcggcgtgg tcgcgccaat cacagcgcgt
99481 gcccgcgacg cactgcaggc cgtgctgcgc gccaggcgcc gcggccagcg ctctgacttg
99541 cgccttatgc gcagaggcgt ggagcgttgt tgaggtcagg cccgcgccga gggccgcgac
99601 tttctcgcta caatcgcgcg cggcgcggga gagccgctag ccgccggtga ccggcgattg
99661 gagattgagt tgcgaccgaa cggatggcgg tgacggtcgg cgtcatttgt gcgatcccgc
99721 aagagctggc gtatctgcgc ggtgtcctgg tcgatgcgaa acgccagcag gtcgcgcaga
99781 tcctcttcga tagcggccaa ctcgacgcgc accgggtcgt gttggccgcc gccggcatgg
99841 gcaaagttaa cacgggcctg accgcaacgc tgcttgccga tcgattcggc tgccgcacca
99901 tcgttttcac gggagtggcc ggcgggctgg atcccgagct atgcatcggt gacatcgtca
99961 tcgccgatcg ggtcgtccaa cacgacttcg gtctgctcac cgatgagcgg ctgcgcccct
100021 atcagcccgg acacatcccc ttcatcgaac cgaccgagcg gctcggatac ccggttgatc
100081 ccgcggtcat cgatcgggtc aaacaccgcc tcgacgggtt cacgctggcg ccgctgtcca
100141 ccgccgcggg aggtggtggc cggcagccac gcatctacta cggcaccatc ctgaccggtg
100201 accaatacct tcactgcgag cgcacccgca accggctgca ccacgaactc ggcggtatgg
100261 ccgtcgaaat ggaaggcggt gcggtggcgc aaatctgcgc gtccttcgat atcccatggc
100321 tggtcattcg cgcgctctcc gatctcgccg gagccgattc gggggtggac ttcaatcggt
100381 ttgtcggcga ggtggcggcc agttcggccc gcgttctgct gcgcttgctg ccggtgttga
100441 cggcctgttg aagacgacta tccgccggtg cgttcaccgc gtcaggcggc ttcggtgagg
100501 tgagtaattt ggtcattaac ttggtcatgc cgccgccgat gttgagcgga ggccacaggt
100561 cggccggaag tgaggagcca cgatgacgac ggccgtgacc ggtgaacacc acgcgagtgt
100621 gcagcggata caactcagaa tcagcgggat gtcgtgctct gcgtgcgccc accgtgtgga
100681 atcgaccctc aacaagctgc cgggggttcg ggcagctgtg aacttcggca cccgggtggc
100741 aaccatcgac accagcgagg cggtcgacgc tgccgcgctg tgccaggcgg tccgccgcgc
100801 gggctatcag gccgatctgt gcacggatga cggtcggagc gcgagtgatc cggacgccga
100861 ccacgctcga cagctgctga tccggctagc gatcgccgcc gtgctgtttg tgcccgtggc
100921 cgatctgtcg gtgatgtttg gggtcgtgcc tgccacgcgc ttcaccggct ggcagtgggt
100981 gctaagcgcg ctggcactgc cggtcgtgac ctgggcggcg tggccgtttc accgcgttgc
101041 gatgcgcaac gcccgccacc acgccgcctc catggagacg ctaatctcgg tcggtatcac
101101 ggccgccacg atctggtcgc tgtacaccgt cttcggcaat cactcgccca tcgagcgcag
101161 cggcatatgg caggcgctgc tgggaagcga tgctatttat ttcgaggtcg cggcgggtgt
101221 cacggtgttc gtgctggtgg ggcggtattt cgaggcgcgc gccaagtcgc aggcgggcag
101281 tgcgctgaga gccttggcgg cgctgagcgc caaggaagta gccgtcctgc taccggatgg
101341 gtcggagatg gtcatcccgg ccgacgaact caaagaacag cagcgcttcg tggtgcgtcc
101401 agggcagata gttgccgccg acggcctcgc cgtcgacggg tccgctgcgg tcgacatgag
101461 cgcgatgacc ggcgaggcca aaccgacccg ggtgcgtccg ggggggcagg tcatcggcgg
101521 caccacagtg cttgacggcc ggctgatcgt ggaggcggcc gcggtgggcg ccgacaccca
101581 gttcgccgga atggtccgcc tcgttgagca agcgcaggcg caaaaggccg acgcacagcg
101641 actagccgac cggatctcct cggtgtttgt tcccgctgtg ttggttatcg cggcactaac
101701 cgcagccgga tggctaatcg ccgggggaca acccgaccgt gccgtctcgg ccgcactcgc
101761 cgtgcttgtc atcgcctgcc cgtgtgccct ggggctggcg actccgaccg cgatgatggt
101821 ggcctctggt cgcggtgccc agctcggaat atttctgaag ggctacaaat cgttggaggc
101881 cacccgcgcg gtggacaccg tcgtcttcga caagaccggc accctgacga cgggccggct
101941 gcaggtcagt gcggtgaccg cggcaccggg ctgggaggcc gaccaggtgc tcgccttggc
102001 cgcgaccgtg gaagccgcgt ccgagcactc ggtggcgctc gcgatcgccg cggcaacgac
102061 tcggcgagac gcggtcaccg actttcgcgc catacccggc cgcggcgtca gcggcaccgt
102121 gtccgggcgg gcggtacggg tgggcaaacc gtcatggatc gggtcctcgt cgtgccaccc
102181 caacatgcgc gcggcccggc gccacgccga atcgctgggt gagacggccg tattcgtcga
102241 ggtcgacggc gaaccatgcg gggtcatcgc ggtcgccgac gccgtcaagg actcggcgcg
102301 agacgccgtg gccgccctgg ccgatcgtgg tctgcgcacc atgctgttga ccggtgacaa
102361 tcccgaatcg gcggcggccg tggctactcg cgtcggcatc gacgaggtga tcgccgacat
102421 cctgccggaa ggcaaggtcg atgtcatcga gcagctacgc gaccgcggac atgtcgtcgc
102481 catggtcggt gacggcatca acgacggacc cgcactggcc cgtgccgatc taggcatggc
102541 catcgggcgc ggcacggacg tcgcgatcgg tgccgccgac atcatcttgg tccgcgacca
102601 cctcgacgtt gtaccccttg cgcttgacct ggcaagggcc acgatgcgca ccgtcaaact
102661 caacatggtc tgggcattcg gatacaacat cgccgcgatt cccgtcgccg ctgccggact
102721 gctcaacccc ctggtggccg gtgcggccat ggcgttctca tcgttcttcg tggtctcaaa
102781 cagcttgcgg ttgcgcaaat ttgggcgata cccgctaggc tgcggaaccg tcggtgggcc
102841 acaaatgacc gcgccgtcgt ccgcgtgatg cgttgtcggg caacacgata tcgggctcag
102901 cggcgaccgc atccggtctc ggccgaggac cagaggcgct tcgccacacc atgattgcca
102961 ggaccgcgcc gatcaccacc ggcagatgag tcaaaatccg cgtggtgctg accgcgccgg
103021 acagcgcatc cacaatcaca tagccggtca gtatggcgac gaacgccgtc agaacaccgg
103081 ccaggccggc ggcggcgctc ggccatagcg ccgcgcccac catgatcaca ccgagcgcaa
103141 tcgaccacga cgtggactcg ttgagcaagt gggtgccggc acccgtcggg tgctgatggg
103201 tcaggccgac gtctaggcca aacccctgca cggtgcccag ggcgatctgc gcgatgccca
103261 cgcacagcaa cgcccaacgt cgccaggtca tcggtgaatg ttgccgccgc ggcgcccggc
103321 ggatcccgag gcgcccaaca ggcgggacaa ccgggcggga ctcggcgagc cgacgcagat
103381 caccagcctg gctggccacc tgggtaaacc atgcgcgaca ggcgctgcac tcgcccaggt
103441 gttcatcgac tctcgccgag ggcaccggtg cgcgctcgcc gtcgagtcgt gccgacagcg
103501 cttcgcgcgc gacctcgcag tccatgccat caatagtcgc gcaatgccga cggattgctc
103561 cagcgggctc ggaccacatc gccgcgggca cacccctgca gccttgcaaa acggttgatg
103621 cgtggtggtt aaagctcccg gccgttgtgg cttgtgcgag cacggtggcc cgggtggtgc
103681 gtgagcgccg tggggctcgc gttcaggggt caatcgggtt tgtcgtcgtc gtcttggttg
103741 tggaggaatc gttcggggtg gtggaaggtg ttggtgcggg gttggccgtg gtcgaggtgg
103801 ggtggtggta gccattcggt gtggccgtgg gtgttgttgt gggtggtcca gcctttttcg
103861 gcgagtcggt tgtcggggcc gcaggccagg gtcagctcgg tgatgtcggt gcgtccggtg
103921 ctggtccagg cggtgacgtg gtgggcttgg ctgtggtagg ccggtgcgtc acagccgggt
103981 ttggtgcagc cgcggtcgtt ggcgaacagc atgatccgct gggccgggga ggctaggcgt
104041 ttggtgtgat acagcgccag gggtgtgccg tggtcgaaga tcgcctgggg gtacctcccg
104101 cttgcggggg agtagtggtg ggcgtggctg gtcatgcgga tcacatcggc catgggtagc
104161 agggtgccgc cgccggtgaa gcccttgccg gcgccggttt gcaggtcggt cagggtggtg
104221 gtgaccacga tcgagacggg aagaccgttg tgttggccca gtttcccgga ggcgatcagc
104281 gcgcgcagcc cggccagcag cccgtcgtgg ttgcgttggg cttggctgcg ggtgtcgcgg
104341 tcgatggcgg ccgcatcggg ggtggtgtcg atgaccgggg tgtggtcgtc ggggttggtc
104401 gcgccggggg cggccagttt ggctagcacg gcttcaaagg tggcccgcgc ttggggggtc
104461 aggtagccac ttagccgtga catgccgtcg tattgctggt tgctcagggt gatgccgcgt
104521 ttgcgggcgc gttcggtgtc ggtgaggtcg ccgtcggggt gtagccagtc catgacccgc
104581 tgggcgtagc gggccagctc gtcgggacga tattgagcgg ctttgccggc caggtcggct
104641 tcggcggcct ggcgggtgga cacatccacc gcggcgggca ggtgggcgaa aaagggcgcg
104701 aatcactttg acgtgcgcct cgccgatcag gccctggcgt tgggcggtgg cggtggcggt
104761 caactgcggg gccaacggtt cgccagtgag cgcccgacgt tgccctaagg cttggcttcg
104821 gcgctgcgtc ggccggcttc gggcttggtg atgcgcagcc ggttggccag cgcgcagcac
104881 agcgtgccgc ccagttcttc ctcgctggct tgggtgtcga gttggttgat caacgtgtgc
104941 tgggccgccg gtagccggcg cgccaagcat tccagacgtt ccagagaccg cagccgttcc
105001 ggggtgctca gcacctcaaa ggacacctcg tccaagcggt ccaggtcggc atccagcgcg
105061 tcgaagacct cgacaagctc ctcccggcta ttcgctaaca tgttcgaatc ataacgtcgg
105121 gcactgacaa agagcgcccc gctgataacc gtgaaactga agtgacacaa gggatttacc
105181 cagatcctac gagttgatac gggaaggtac cgcacctttc ctgggcgcga tgggaacttt
105241 ctgcccgtta tggccgacta acaccgcggg tgaagcaaag cgctgcctag gcaaggaggt
105301 gagtcctggc ggccacgata tggatggcta taccaccgga ggtgcactcg ggcctgttga
105361 gcgccgggtg cggtccggga tcattgcttg ttgccgcgca gcagtggcaa gaacttagtg
105421 atcagtacgc actcgcatgc gccgagttgg gccaattgtt gggcgaggtt caggccagca
105481 gctggcaggg aaccgccgcc acccagtacg tggctgccca tggcccctat ctggcctggc
105541 ttgagcaaac cgcgatcaac agcgccgtca ccgccgcaca gcacgtagcg gctgccgctg
105601 cctactgcag cgccctggcc gcgatgccca ccccagcaga gctggccgcc aaccacgcca
105661 ttcatggcgt tctgatcgcc accaacttct tcgggatcaa caccgttccg atcgcgctca
105721 acgaagccga ttatgtccgc atgtggctgc aagccgccga caccatggcc gcctaccagg
105781 ccgtcgccga tgcggccacg gtggccgtac cgtccaccca accggcgcca ccgatccgcg
105841 cgcccggcgg cgatgccgca gatacccggc tagacgtatt gagttcaatt ggtcagctca
105901 tccgggatat cttggatttc attgccaacc cgtacaagta ttttctggag tttttcgagc
105961 aattcggctt cagcccggcc gtaacggtcg tccttgccct tgttgccctg cagctgtacg
106021 actttctttg gtatccctat tacgcctcgt acggcctgct cctgcttccg ttcttcactc
106081 ccaccttgag cgcgttgacc gccctaagcg cgctgatcca tttgctgaac ctgcccccgg
106141 ctggactgct tcctatcgcc gcagcgctcg gtcccggcga ccaatggggc gcaaacttgg
106201 ctgtggctgt cacgccggcc acggcggccg tgcccggcgg aagcccgccc accagcaacc
106261 ccgcgcccgc cgctcccagc tcgaactcgg ttggcagcgc ttcggctgca cccggcatca
106321 gctatgccgt gcccggcctg gcgccacccg gggttagctc tggccctaaa gccggcacca
106381 aatcacctga caccgccgcc gacacccttg caaccgcggg cgcagcacga ccgggcctcg
106441 cccgagccca ccgaagaaag cgcagcgaaa gcggcgtcgg gatacgcggt taccgcgacg
106501 aatttttgga cgcgaccgcc acggtggacg ccgctacgga tgtgcccgct cccgccaacg
106561 cggctggcag tcaaggtgcc ggcactctcg gctttgccgg taccgcaccg acaaccagcg
106621 gcgccgcggc cggaatggtt caactgtcgt cgcacagcac aagcactaca gtcccgttgc
106681 tgcccactac ctggacaacc gacgccgaac aatgaacaag gagaaaagaa ccgatgacgc
106741 ttaaggtcaa aggcgaggga ctcggtgcgc aggtcacagg ggtcgatccc aagaatctgg
106801 acgatataac caccgacgag atccgggata tcgtttacac gaacaagctc gttgtgctaa
106861 aagacgtcca tccgtctccg cgggagttca tcaaactcgg caggataatt ggacaaatcg
106921 ttccgtatta cgaacccatg taccatcacg aagaccaccc ggagatcttt gtctcctcca
106981 ctgaggaagg tcagggggtc ccaaaaaccg gcgcgttctg gcatatcgac tatatgttta
107041 tgccggaacc tttcgcgttt tccatggtgc tgccgctggc ggtgcctgga cacgaccgcg
107101 ggacctattt catcgatctc gccagggtct ggcagtcgct gcccgccgcc aagcgagacc
107161 cggcccgcgg aaccgtcagc acccacgacc ctcgacgcca catcaagatc cgacccagcg
107221 acgtctaccg gcccatcgga gaggtatggg acgagatcaa ccggaccacg cccccaataa
107281 agtggcctac ggtcatccgg cacccaaaga ccggccaaga gatcctctac atctgcgcga
107341 cgggcaccac caagatcgag gacaaggacg gcaatccggt tgatccggag gtgctgcaag
107401 aactcatggc cgcgaccgga cagctcgatc ctgagtacca gtcgccgttc atacatactc
107461 agcactacca ggttggcgac atcatcttgt gggacaaccg ggttctcatg caccgagcga
107521 agcacggcag cgccgcgggc actctgacga cctaccgcct gaccatgctt gatggcctca
107581 agacgccggg atacgcggca tgagccacac cgacttgacg ccctgcacac gggtgctggc
107641 atccagcggc acggttccga tcgcagagga actgctggcc agagtgctcg agccctactc
107701 ctgcaaagga tgtcgctacc tcatcgacgc acagtacagc gccaccgagg attcggttct
107761 tgcctatggc aacttcacga tcggtgagtc cgcctatatt cgaagcacgg ggcacttcaa
107821 cgcggtcgaa ctgattctgt gtttcaatca gctcgcctac agcgccttcg ctccggccgt
107881 cctcaacgag gaaatccggg tgcttcgcgg ctggtcgatc gacgactact gccaacacca
107941 gctctctagc atgctgatca ggaaggcatc atcgcggttc agaaaaccgc tgaacccgca
108001 aaagttctct gcccgcctcc tgtgtcgaga tctgcaggtc atcgaacgaa cctggcgcta
108061 tctcaaggtc ccgtgcgtca tcgagttctg ggacgagaac ggcggggcgg cgtccggtga
108121 gatcgaacta gcggccctca acattccgta atccaatggg aggaaagaag tttcaagcta
108181 tgcctcagtt gccatctacc gtgctggacc gggtcttcga gcaggcacgg cagcagccgg
108241 aagcaatcgc cttgcgtcgc tgcgacggca ctagcgcact gcggtaccgt gaactcgtcg
108301 ccgaagttgg tggccttgcc gcggatttgc gtgcccagtc ggttagccgg ggttctaggg
108361 tgctggtcat ttccgacaat ggacccgaga cgtacctgtc ggtgctggcg tgtgcaaagc
108421 tcggggcgat cgccgtcatg gccgacggca atcttccgat cgcagccatc gaacgattct
108481 gtcagatcac cgaccccgca gcggctctcg tcgcaccagg gagcaagatg gcatcttccg
108541 ccgttcccga ggcgctgcac tcgataccag tgatcgcggt cgacatagcc gctgttacac
108601 gggaatccga gcattccttg gatgcagcca gcctcgccgg gaacgcggac caggggagcg
108661 aggatccgct ggcgatgatc ttcaccagcg gtaccacggg cgagcccaag gctgtgctac
108721 tggccaaccg caccttcttc gccgtcccgg acatcttgca aaaagagggt ttgaactggg
108781 tcacttgggt cgtcggcgaa accacctact cgccgctgcc ggcgacgcac atcggtggac
108841 tgtggtggat acttacctgc ctgatgcacg gcgggttgtg tgtcaccggc ggcgagaata
108901 cgacatcgtt gctggagatt ctcaccacga acgcggtggc gacgacgtgc ctagtgccaa
108961 cgcttctttc gaagttagtt tctgaactga agtccgccaa cgcgacggtt ccctcgctgc
109021 gcctagttgg atacggtggt tcgcgggcga tcgcggccga tgtgcggttt atcgaagcta
109081 ccggcgtgcg caccgcacag gtctacggat tgagcgagac cggttgcacg gctttgtgtt
109141 tgccgaccga tgacggctcg atcgtcaaga tcgaagcagg tgctgttggc cgtccgtacc
109201 ctggcgtgga cgtctatctt gccgctaccg atggcatcgg ccctaccgcc cccggcgccg
109261 gcccgtccgc ctcgttcggc acgctatgga ttaagtcacc ggccaacatg ctgggctact
109321 ggaacaatcc cgaacgcacc gcagaggtgc tgattgacgg ctgggtgaac accggtgacc
109381 tgctggagcg ccgcgaggac ggcttcttct acatcaaggg aagatcctcg gagatgatca
109441 tctgtggtgg cgtgaacatt gcgcccgacg aggtcgatcg catcgcggag ggcgtgtcgg
109501 gcgtccgcga ggccgcgtgc tacgagattc ctgacgaaga gttcggcgcg ctggtgggcc
109561 tggccgtggt cgcatcggca gagcttgacg agtcggcagc ccgggcgctc aagcacacga
109621 ttgcggctcg ttttcgacgg gagtccgagc cgatggcgcg gccgtcgaca attgtgatcg
109681 tcaccgacat tccacgaacg cagtccggca aggtcatgcg ggcctcgctt gcagcggcgg
109741 caacagcaga caaggccaga gtggtcgttc gtggctgagc cggtgcggga ccgaatcctc
109801 gccgccgtct gcgacgtgtt gtatatcgac gaggcggatc tcattgatgg cgacgaaacg
109861 gatctccgcg acctcgggct ggactctgtt cggtttgttc tgctgatgaa gcagctaggc
109921 gtgaaccgac aatccgaact gccgtcccga ttggccgcga acccgtcgat tgcgggttgg
109981 cttcgcgagc tggaggctgt gtgcaccgag ttcggttaag ccgctcgcag cgcaacctct
110041 acaacggcgt gcgccaggat aacaatcccg cgttatatct gatcggcaag agctatcggt
110101 tccgccggtt ggagctggcg agattcctgg ccgctctgca cgcaacggta ctggacaacc
110161 ccgtgcaact ttgcgtcctg gagaattcgg gggcagacta tccggatctg gtgccgcggc
110221 tacggttcgg cgacatcgtg cgggtggggt cagccgatga gcacctgcag agcacatggt
110281 gttcgggcat cctgggcaag ccactggtgc ggcatacggt gcacaccgac ccgaacgggt
110341 atgtgaccgg tctggacgtt cacacccacc acatcctgct ggacggcggc gcgaccggga
110401 cgatcgaagc tgacctggcg cgttacctga ccaccgaccc ggcgggcgaa acccccagtg
110461 tcggtgcggg tctagccaag ctcagggagg cgcaccgtcg tgagacggcc aaggtggaag
110521 aatcgcgggg gcgcctgtcg gctgtcgtgc agcgtgaact cgccgacgaa gcataccacg
110581 gcgggcacgg gcacagcgtt agcgacgctc ccgggaccgc ggccaagggc gtcctgcacg
110641 aatcggcaac gatctgcggc aacgcgtttg atgccatcct gaccctttcg gaagcgcagc
110701 gggtcccgct taatgtgctg gtggctgcgg cggccgtcgc ggtggacgcg agccttcggc
110761 agaacaccga aaccctcttg gtgcacacgg tggacaaccg gttcggagat tctgatctga
110821 atgtcgcgac ctgtttggtc aattcggttg cccagaccgt ccggtttccc ccatttgcgt
110881 cggtgtccga tgtcgttcga acgcttgacc gcggctatgt caaggcggta agacgccggt
110941 ggcttcgtga ggagcattac cgccgaatgt atttggcgat caaccggaca tctcacgtgg
111001 aggcgttgac gctaaatttc attcgcgagc catgcgcacc tggcctgcgc ccgttcttgt
111061 cggaggtccc gattgccacg gatatcggtc cggtcgaggg catgacggtg gcgtctgttc
111121 tggacgaaga acagcgcaca ctgaacctag ccatctggaa ccgagccgat ctgcccgcgt
111181 gcaagacaca ccccaaggtc gcggaacgga tagcggcagc gttggaatcg atggcggcga
111241 tgtgggatcg gccgatcgcc atgatcgtca acgactggtt cgggatcggc ccggacggga
111301 ctcgctgcca aggcgattgg ccagcccgtc agccgtcgac gcccgcgtgg tttctcgatt
111361 ccgcaagggg cgtccaccaa tttctcggca ggcgccgctt cgtctacccg tgggtcgcgt
111421 ggttggtgca acgcggcgcc gcaccgggtg atgttctggt gttcaccgac gacgacaccg
111481 acaagaccat tgacctgctc atcgcgtgtc accttgcggg ttgcgggtac agcgtctgcg
111541 acaccgctga cgaaatttcc gtgcggacca atgcgattac cgagcacggc gatggcatct
111601 tggtgacagt ggtcgacgtg gccgccaccc agctggcggt tgtcggccat gacgagctgc
111661 ggaaggtcgt tgacgagcgc gtcacacagg tgacacacga cgcactgctg gccaccaaga
111721 ccgcctacat catgccgacc tcgggaacta ccggacaacc caagctggtg cgaatctcac
111781 acggctcgct cgcggttttc tgtgatgcga tcagccgcgc ctacggttgg ggagcccacg
111841 acaccgttct gcagtgcgct ccgttgacat cggacatcag cgtcgaggag attttcggtg
111901 gcgcggcctg tggcgcgcga ctggtgcgat ccgcggctat gaaaaccggc gacctggcgg
111961 cgctggttga cgatctcgtc gcccgcgaga cgacaatcgt cgacctgccg accgccgtct
112021 ggcagctgtt gtgcgccgac ggcgacgcca ttgacgcgat cggccgctcg cgcctgcggc
112081 agatcgtaat cggcggtgaa gccatccgct gtagcgccgt ggacaagtgg cttgaatcgg
112141 ctgcttcaca agggatctcg ctgctctcga gctatggtcc aacagaagcc acggtcgtcg
112201 ccaccttctt gccgatcgtt tgcgaccaga ccaccatgga cggcgcactg ctcaggctcg
112261 gccggccgat cctaccgaac acggtgttcc tcgcgttcgg tgaagtcgtc attgtcgggg
112321 atttagtcgc cgacggctac ctcgggatcg acggcgacgg cttcggcacc gtgacggccg
112381 cagacggttc ccgacgccgt gcctttgcca ctggcgaccg ggtgaccgtc gacgccgaag
112441 gatttccggt cttctccgga cgcaaagacg ccgtcgtcaa gatctccggc aagcgtgtcg
112501 atatcgctga ggtaaccagg cgcatcgccg aagaccccgc ggtgtcagat gtcgccgtcg
112561 agttgcacag cggaagcctc ggagtgtggt tcaagagcca acggacccgc gagggcgaac
112621 aagacgctgc cgcggcgacc cggatcaggc tcgtcctcgt gagtctggga gtgtcgtcgt
112681 ttttcgttgt cggcgtgccg aatatcccga ggaagcccaa cgggaagatc gacagcgaca
112741 acctgccgag gctgcctcag tggtcagctg ctgggctaaa caccgccgag acgggtcagc
112801 gagcggccgg cctctcgcag atctggagcc ggcagctcgg ccgggcaatc gggccggact
112861 cgtcgctgct tggtgagggc atcggctcgt tggatctcat cagaatactg cccgagacgc
112921 gtaggtatct ggggtggcgc ctctcgctgc tggatctgat cggtgccgat accgccgcca
112981 atctggccga ttacgcgcca acgcccgacg cgccgacggg cgaagatcgg tttaggccgc
113041 tggtggccgc gcaacggccc gcggcgattc cgttgtcgtt tgcccagcgg cgactatggt
113101 ttctcgacca gttacagcga cccgctccgg tctacaacat ggcggtggcg ttgcggctgc
113161 gcgggtatct cgataccgag gcgttgggcg cggcggtcgc cgatgtcgtg ggccgccacg
113221 aaagcctacg gacggtgttt ccggcggtcg acggggtccc tcggcagctg gtcatcgaag
113281 cgcggcgggc agatcttggc tgcgacatcg tcgatgccac cgcatggccg gctgaccggc
113341 tgcaacgggc catcgaggag gcggcgcgcc acagcttcga tttggcaacc gagatacctt
113401 tgcggacgtg gcttttccgg atcgccgacg acgaacatgt gctggtggcg gttgcacacc
113461 atatcgccgc cgacggctgg tcggtggctc cgctgacggc cgatctgagt gcggcatatg
113521 ccagccgttg tgcgggtcgg gcaccggact gggcgccatt gccagtgcag tatgtcgatt
113581 acacgctgtg gcagcgggaa atcctcggtg atctcgacga cagcgacagc ccgatcgccg
113641 cgcagctggc ctactgggaa aatgcgttgg ccggtatgcc ggaacggctg cggctgccca
113701 ccgctcggcc ctatccaccg gttgccgatc agcgcggcgc cagtttggtg gtggattggc
113761 cggcgtcggt gcaacagcag gtgcgtcgga tcgcccgcca gcacaacgcg accagcttca
113821 tggtggtagc tgccgggctt gccgtgctgc tgtcgaaact cagcggaagc cccgatgtgg
113881 cggtcggatt tcccatcgcc ggccgcagcg atcctgcgct ggataacttg gtgggctttt
113941 ttgtcaacac cttggtgttg cgggtcaacc tggccggtga tcccagcttc gccgaactgc
114001 tggggcaggt gcgagcgcgc agcctggccg cctacgaaaa tcaagacgta cctttcgagg
114061 tgctcgttga tcgcctcaaa cccactcgag ccctgaccca tcacccgctg atccaggtga
114121 tgttggcctg gcaggacaat ccggttggac agctgaattt gggtgatctg caggccaccc
114181 cgatgccgat cgacacccgc accgcccgca tggacttggt gttttcgtta gcggaacgct
114241 tcagcgaggg tagcgaacct gccgggatcg gcggagcggt ggaataccgc accgatgtgt
114301 ttgaagccca agcaatcgac gtgcttatcg agcggttgcg gaaggtgttg gtggcggtgg
114361 ccgctgctcc ggaacggacg gtgtcgtcga tcgatgcgct ggatgggacc gagcgtgccc
114421 ggttggatga gtggggtaac cgcgctgtgc tgactgcgcc cgcgcccacg ccggtgtcga
114481 tcccgcagat gttggccgcc caggtggcac gtatccccga agcggaggcg gtgtgttgcg
114541 gggacgcgtc gatgacgtat cgggaactcg acgaggcgtc caaccggtta gcgcatcggc
114601 tggcaggttg tggggccggc ccgggcgagt gtgtggcgct gctgttcgag cggtgcgcgc
114661 cggcggtcgt ggcgatggtg gcagtgctca aaaccggggc ggcgtatctg ccgatcgatc
114721 cggcgaatcc tccgccgcgg gtggcgttca tgctcggcga cgcggtgccc gtggccgcgg
114781 tcaccacggc tgggctgcgc tcccggttgg cgggacacga cttgccgatc atcgatgtcg
114841 tcgatgcttt agcggcatat ccgggcacgc ccccacccat gccggccgca gtgaacctcg
114901 cctacatcct gtacacctcg ggcactaccg gcgagcccaa aggcgtgggg atcacccatc
114961 gcaacgtcac caggctgttc gcatcactgc cggcacgctt gtcggcggcg caggtgtggt
115021 cgcagtgtca ttcctatggc ttcgacgcct cggcgtggga gatctggggc gcgttgctag
115081 gtggtgggcg actggtgatc gtgcccgagt cggtggcggc ctcgccgaac gactttcatg
115141 ggctgctcgt ggccgaacac gtcagcgtgc tgactcagac tccggctgcg gtggcaatgt
115201 tgccgacgca gggtttggag tcggtggcgt tggtggtggc cggtgaggca tgtccggcag
115261 cgctggtgga tcggtgggcg cccgggcggg tgatgctaaa tgcttatggc ccaaccgaga
115321 ccacgatctg tgcggcgata agtgcgccgt tgcgaccggg ttcggggatg ccgccgattg
115381 gtgttccggt gtcgggggcg gcgttgtttg tgctggatag ctggttgcgc ccggtaccgg
115441 ccggggtggc cggagagttg tacattgccg gtgcgggcgt cggtgttggg tattggcgtc
115501 gggcggggct gaccgcgtca cggtttgtgg cctgcccatt cggcggttcc ggggcacgca
115561 tgtatcgcac cggggatctg gtgtgttggc gcgccgatgg ccagttggag ttcctggggc
115621 gcaccgacga tcaggtcaag atccgcgggt atcgcatcga gctcggcgag gttgcgaccg
115681 cgctggccga gctggctggg gtaggtcaag cggttgtaat cgcccgtgaa gaccgccctg
115741 gggacaagcg cctagtcggg tatgccaccg aaattgcccc cggggcagtg gacccggccg
115801 ggctgcgggc gcaactagcc cagcgattgc ccggttacct ggtgccagcc gcggtggtag
115861 tgatcgatgc gcttccgttg acggtcaacg gcaaacttga tcatcgtgcg ttgccggcac
115921 cggaatacgg tgataccaac ggatatcgcg ctccggccgg gccggttgag aagaccgtgg
115981 ccggcatctt tgcccgggtt cttgggcttg agcgggtcgg cgtcgacgac tcgttcttcg
116041 agctcggcgg cgattcgctg gcggcaatgc gggttatcgc cgcgatcaac accaccctaa
116101 acgccgatct gccggtgcgc gcgttgctgc acgcgtcgtc gacgagaggt ttaagccagc
116161 tgttggggcg agatgcccga ccgaccagcg atccgcgctt ggtgtctgtg cacggcgaca
116221 accccaccga ggtgcatgcc agcgacctca cgctggaccg gttcatcgac gccgacacgc
116281 tggccaccgc cgtcaacctg ccgggcccga gccccgagct acggacggtc ctgctgacgg
116341 gcgcgacggg tttcctcgga cggtatctgg tccttgaatt gctgcggcgg ctggacgtcg
116401 acggcaggct gatctgtttg gtgcgggcgg agtccgacga ggatgcgcgg cgtcgtctgg
116461 agaagacctt cgatagcggt gacccggaat tgctgcggca cttcaaggag cttgccgccg
116521 accggctgga ggtcgtcgca ggcgacaaga gcgaacccga cctgggcctg gaccaaccga
116581 tgtggcggcg gctggccgaa accgtggatt tgattgtcga ttccgcggcg atggtcaacg
116641 cgtttcccta ccacgaattg ttcgggccca acgtcgcggg caccgccgag ctgatccgaa
116701 tcgcgcttac caccaagctc aaacccttca cctacgtgtc aaccgccgac gtgggtgctg
116761 cgatcgagcc gtcggcgttc accgaggacg ccgacatccg ggtaatcagc cccacccgca
116821 ccgtcgacgg cggctgggct ggcggctacg gcaccagcaa gtgggccggt gaggtgctgc
116881 tgcgcgaggc caacgacctg tgcgcgctgc cggtcgcggt gtttcgctgc gggatgatcc
116941 tggccgacac cagctatgcc ggacagctca acatgtcgga ctgggtcacc cggatggtgt
117001 tgagcttgat ggctaccggc atcgcgcctc gttcgttcta cgaaccggac tccgagggca
117061 atcggcaacg cgcgcacttc gacgggctgc cagtcacctt cgttgccgag gcgatcgcgg
117121 tgctgggcgc gcgggtggcc ggctcatcgt tggcgggatt tgcgacctat cacgtgatga
117181 acccgcacga cgacggtatc gggctcgatg agtatgtgga ctggctgatt gaggccggct
117241 acccgatacg ccgcatcgat gactttgcgg agtggttgca gcggtttgag gccagcctgg
117301 gcgctctgcc ggatcggcaa cgccggcact cggtgctgcc gatgctgctg gcgagcaatt
117361 cccagcgatt gcagccgctt aagccgacca gggggtgctc cgcgccgacc gaccgattcc
117421 gtgccgcggt gcgagcggcg aaagtcggct ccgacaagga caatccagac atcccgcacg
117481 tgtcggcgcc gaccatcatc aactacgtca ccaacctaca actgctcgga ctgctgtagt
117541 tgctcggcga taaagagcgc agccatggtc gggggagatc atgtggtcac tttcgggtcg
117601 gcatcgattc tgcgagcaga atatgtggtt gatggccact aggccggtac cggggaactg
117661 gcggttcccg gccgatgagc atcggccctg acgcgcggcc gtaagctcca ggaatgggga
117721 cgcacggggc taccaagagt gcgacgtcgg ctgtgccaac gccccggtcg aactccatgg
117781 cgatggtacg gctggcaatt ggcctgctgg gtgtgtgcgc ggtggtcgcg gccttcgggc
117841 tggtgtcggg agcgcgccgc tacgctgagg ccggcaatcc ctatccgggc gccttcgtca
117901 gcgtcgccga gccggtcggg ttcttcgccg cgtcgctggc cggtgcgctg tgtctgggcg
117961 cgctgatcca cgtggtcatg acggccaaac ccgagccgga tggcttaatc gacgccgcgg
118021 cgttccggat tcacctgctg gcagaacgtg tttcaggtct ctggttgggg ctagccgcga
118081 ccatggtggt cattcaggcc gcccacgata ctggagtggg gcccgcgaga ctgctggcta
118141 gtggggcact atcggactcc gtcgccgcct ccgagatggc acgcgggtgg attgttgcgg
118201 cgatctgcgc gctggtggtt gcgacggcgc tgcggctgta cactcgctgg ctcgggcacg
118261 ttgtgctgct tgtccccact gtgcttgccg tcgtcgccac cgcggtgacc ggtaacccgg
118321 gacagggacc cgaccatgac tacgcgacca gcgccgcgat cgtgttcgcg gtcgcgttcg
118381 ccaccttgac cgggctcaag atcgctgcgg cgttggcggg aacgacgcca agccgcgctg
118441 tgctggtaac gcaggtcacc tgtggagcgc tcgcgttggc atacggagcg atgctgcttt
118501 atctcttcat cccgggctgg gcggtcgatt cggattttgc ccgccttggt ctgcttgcgg
118561 gggtaatcct gacgtcggtg tggttgtttg actgctggcg gctgttggtc aggccgccac
118621 atgcgggccg tcgccgcggt ggtggctccg gtgccgcact ggccatgatg gccgccatgg
118681 cttcgatagc tgccatggcc gttatgaccg cgccgcgatt tctcacccac gcgttcacgg
118741 cttgggatgt cttcctcggc tatgaactgc cgcaaccgcc gaccatagcc cgggtgctca
118801 ccgtgtggcg cttcgatagc ctgatcggag ccgctggtgt ggttctcgcg atcgggtatg
118861 cggcgggctt cgccgcgctg cggcgccgag gtaactcttg gccggtgggc agattgatcg
118921 cctggctgac tggttgcgcc gcactggtat tcaccagcgg ctccggtgta cgggcctatg
118981 gttcggcgat gttcagcgtc cacatggccg aacacatgac actgaacatg ttcatcccgg
119041 tcctgttggt gctcggtggc ccggtcacgc tggcgctgcg ggtgctgccg gtaacgggtg
119101 atggacggcc gccgggggct cgcgaatggc tgacctggct gctgcactcc cgggtgacaa
119161 ctttcctgtc gcacccgatc accgcattcg tcctctttgt ggcctcgccc tatatcgtct
119221 atttcacacc gctgttcgat accttcgtcc gctatcactg gggccacgag ttcatggcga
119281 tccatttcct ggtggtcggg tacttgttct actgggcgat catcggcatc gacccagggc
119341 cgcgccgact gccctacccg ggccggatcg ggctgttgtt cgcggtgatg ccgttccacg
119401 ccttcttcgg gatcgcgctg atgacgatgt cgtctacggt gggcgctacg ttctatcgtt
119461 ccgtcaatct gccgtggttg tcgagcatca tcgccgacca gcatctcggc ggtggaattg
119521 cttggagcct aacggaattg ccggtcatca tggtcatcgt ggcgctggtt acccaatggg
119581 cgcgccaaga ccgccgagtc gcgtcccgcg aagaccggca tgccgacagc gactacgccg
119641 acgacgagct ggaagcctac aacgcgatgc ttcgcgagtt gtcgcgaatg cggcgctgaa
119701 tgtgcagatg attttggaag cggttggcgt atctgcccgt gctcggctac accaggaccg
119761 cggggcgctg gcacgcgaac gatccggcga ggaggtgggc cagccggaga ttccctccac
119821 aggctgcagc agaagtcctg gatctgaccc cgacctgaac ccttgtcagt gcggtccatc
119881 gacggaaaat tgctgttccg ccatgctggg catgctattg agcgccaaaa ttgcgtagcc
119941 gcaagctgtt tgacacgacg aaaaatgacg agaacgccat ggcggcaccg gcgatcaaag
120001 ggttgagcag tccggcggcg gcaatcggga tggctgcgac gttgtacccg aacgcccaga
120061 tcatgttcat ccggatcgtc cgcatggttg cacgggccag gtccagcgcc tgcggaacag
120121 tattcagatc atcgcgcacc agaatgatgt cggctgcacc gagcgcgacg tcggtgccac
120181 gcccgatcgc caaccccaag tcggcaccca ccaacgcggg accgtcgttg atgccgtcac
120241 cgaccatggc gacggtatgt ccttcctcgc ggagccgttg gatcacgtcg accttgcctt
120301 cgggcagcat atcggcgaca gcggagtcga tgccgacctg cgccgccacc gcgtcggcgg
120361 cggcccgatt gtcgccggtg agcagaatcg tccgcagccc gcggctgcgt agcgcagcga
120421 cggcggcagc cgctgaatcc ttgagggtgt cggcgattgt cagggctgcg cggacgacac
120481 cgtcgaccga cacaaaaacg acagtctcgc ctcgggattc gccgtccagg cgcgcggaca
120541 ccagagccgc gtcgtggcag ggcgtggtcc gggtaatcca ggatggcttg ccgacctcaa
120601 cgtgatggcc gccgacttcc cccgatacac cgcagcccgc gacggcgaca aacccgttga
120661 ctggacccgg atccggcgaa gcggcaacga tggccgccgc catcgcatgc tcggaagccg
120721 attcgacagc ggcggcgagg ccaagcactt cctcgcgatc tcgctcgctg gtgcctgaac
120781 ctgccattgt tacggtgctc accgccagct gcccaaccgt caacgtgccg gtcttgtcga
120841 acaccacggt gtcgatgctc cggatggttt ccagtgcccg gtaccccttg ataaagatcc
120901 ctagctgcgc tccccgtccg gaagcaacca tcatggcggt aggtgtcgcg agcccaagcg
120961 cacacgggca cgcgatcacc aacaccccta gcgtgaccga gaacgcgcga tccgcgcctg
121021 cgccgctgac gagccaggcc gcacctgcaa gtccagcaat gacgaaaacc accggcacga
121081 acacgcccgc gatgtggtcg gcgaggcgct gggcacgcgc cttctgcgtc tgggcttgct
121141 ccacgaggcg gaccatcgcg gcgaactggg tatcggcccc taccgcggtg gcctcgatga
121201 ccaggcggcc gtccatcacg accgtgcccc ccacgaccga ggccgccgga taggcacgga
121261 ccggcttggc ctcaccggtc atggcgctca tatcgatcgc cgcgctgccg tcgacaacga
121321 ctccgtcagc tgcgatggtt tcccccggcc gcgtcacgaa gcgctggcgc ttcttgagtt
121381 cgctcgccgg tatcactagc tccgcgccgt cgggcagcag caccgccaca ttcttggcgc
121441 ctagctccgc cagcgcacgc agcgcgctgc cggccttgga cttggctcgt gcttcaaagt
121501 aacgaccggc aagaacgaag acggtcacac cggccgcgac ctcgaggtag atcgagtcgc
121561 tgttgagaat ggcccgccag attcccgagc cttcccgtgg cggctgatcg ccgaagacgg
121621 acgaaagcga ccaggcggtg gcggccacga tcccgaccga gatcagcgtt tccatggatg
121681 tcgtccggtg gcgcgcgttt cgcagcgcga ccgagtggaa gggccatgcg gcccaggtca
121741 caaccggagc ggccagggcc gtcaatatgt atccccagcc gggaaccctg gcgctgggga
121801 cgatcgcgaa caacgtcgac aggtcagcca gcggcacgaa caacaccgcc gcgactagca
121861 gccgccgcag cagtctgcgg gcgtgggcgc cgtcgggatc ctttgtccgt ttgtctagga
121921 cggttgtctc ggtgtgcggt gccgcgtggt atccggcttt ctcgaccacc ccgcacagct
121981 catcggctgc catgcccacg gcatcgatgg tcgcgacgcg ggttgcgaag ttgacggatg
122041 cgcgtactcc ggggatcttg ttgagcttcg tctcgacgcg gctggcacag gccgcacatg
122101 acatacccaa aacatcgagc cggatccgcc gcaccgactg caggtcggca tctcccacaa
122161 ctggagccgc cacggccctc ctcggatcgg cgtatttgca cccgtcagcc tacaagtcgt
122221 aagcaggcgg taatcggttc cctatggccc gctggatgca ctggcgatgg attcttttgg
122281 tccgatttct gcggttggcg tgctaggttt ccgactgtga cgcccgtcac aacgtttcct
122341 ctcgtggacg cgatcctcgc tggtcgcgac cgcaaccttg acggcgttat cttgatcgcc
122401 gcccaacacc tgctgcaaac aacgcacgcc atgctgcgtt cgctatttcg ggtcggcctc
122461 gatccgcgca acgtcgcggt gatcggcaag tgctattcca ctcacccggg agttgtcgac
122521 gcgatgcggg ccgacggcat ctatgtcgac gattgcagcg acgcctacgc accccacgaa
122581 tcattcgaca cccagtacac ccgccacgta gaacggtttt tcgccgaatc ctgggcgcgg
122641 cttacggccg ggcgtacggc tcgtgtcgtg ctcctcgacg acggcggatc gctgctagcc
122701 gtcgccggcg ccatgctcga tgcgagcgcc gacgtgatcg gaatcgagca gacgtccgcc
122761 ggctacgcca aaatcgtcgg ttgtgcgctg gggtttcccg tcatcaacat cgcccgctcg
122821 tcggcaaagc ttctatacga gtcgccgatc atcgccgcac gcgtgacaca gacggcattc
122881 gagcgcaccg cgggcatcga ctcaagcgca gcgatcctga tcaccggcgc gggcgcaatc
122941 ggcactgccc tggccgatgt gctgcgtccg ctgcatgacc gggtggacgt gtacgacacg
123001 cgctccggct gtatgacgcc catcgatctt ccgaatgcga tcggcggcta tgacgtgatc
123061 atcggtgcca ccggcgccac cagtgtgccc gccagcatgc acgaattgct gcgccccggc
123121 gtattgctga tgtcggcgtc ttcgtccgat cgcgagttcg atgccgtcgc gttgcgtcgg
123181 cgcacgacgc ccaatcctga ctgccatgcc gacctcaggg tagccgacgg cagtgtcgac
123241 gctaccttgt tgaattcggg cttcccggtc aactttgacg gttcgcccat gtgcggcgat
123301 gcgtcgatgg cgctcacgat ggcgttgttg gcggccgcgg tgttgtatgc gtcggtcgcg
123361 gtcgccgacg aaatgtcatc cgatcatccg catctcgggc tgatcgacca gggcgacatc
123421 gtggcatcgt ttctgaacat cgacgtcccg ctccaagctc tcagccggct accgttgctt
123481 tcgatcgatg ggtatcgccg ccttcaggtg cgctccggct ataccttgtt ccgccaaggt
123541 gagcgggccg accacttctt tgtcatcgaa tccggcgagc ttgaggcgct cgtcgacggg
123601 aaggtcatcc ttagactcgg tgccggagac cacttcggcg aggcgtgttt gctcggtggc
123661 atgcggcgca tagcgacggt gcgggcatgt gagccatcgg tcctgtggga gctcgacggc
123721 aaggctttcg gcgacgcgct gcatggggac gctgcaatgc gtgagatcgc ctacggtgtc
123781 gctcgcaccc ggctcatgca cgccggcgcg tccgagtcct tgatggtgta acggtcttgc
123841 actcgtgggc tgtcggcgga tcacgggatc gttatgccgg ttcttgcgag tgacataggt
123901 tgacatacgt ataaccggtc cctgcggtcg aacacggctt gacaattgga cgaatctcgt
123961 tgcgcgccat cagttgtgct cacaggatcg ccgccgttcg gagcgatgag cccgcttggc
124021 gcgcgaagtg cgccggggcg gatcctgccc gagccgcgcg acgacggcct cgatgcccgt
124081 cgcggtcgat gaccttgatt ccttgggcgc tgacccgcac cttgatgcgg cggtcctccg
124141 acggtaagta gtaggccttg agctggatat tgggcggcca acgtcgccga gtgcggcggt
124201 gtgagtgcga cacagcctta ccgaaaccca cagtgcggcc ggtgatttgg cagcgggcgg
124261 acatggcgaa cctcctcccg gaccagcctg ttgaaaatag ttttcgacaa ccgttgcacg
124321 gcacggtagc gtgggtgcag tttaatggca atcattttca ataaggtttg gcgatgcgta
124381 ctccggtgat attggtggca ggtcaggatc acaccgacga ggtgacgggc gccttgttgc
124441 gccggaccgg aacggtggtc gtggagcacc ggtttgacgg ccatgtggtg cgacggatga
124501 ctgccacgct gagccgtggc gaattgatca ccacggagga cgctttggag ttcgcccacg
124561 gctgtgtgtc gtgcacaatc cgcgacgacc tgctggtgct gttacgcaga ctgcaccgcc
124621 gagacaatgt cggccggatc gtcgtgcacc tggcgccgtg gctggagccc cagcccatct
124681 gctgggcgat cgaccacgtg cgggtttgcg tcggacacgg atacccagac ggaccagccg
124741 ccctcgacgt gcgggtcgcg gccgtggtga cctgtgtgga ctgcgtaagg tggctgccgc
124801 agtcactcgg cgaggacgaa ctgcccgacg ggcgcacggt ggcccaagtg acggtcggtc
124861 aggccgagtt cgccgacctt ctggtgctga cccacccgga accggtcgcc gtggcggttc
124921 tgcgccgact ggcccctcga gcgcgaatca ccggcggcgt cgaccgcgtc gagctggcgc
124981 tggcgcatct ggacgacaac tcacggaggg gtcgtaccga taccccgcac acgccattgc
125041 tggcgggcct gcctccgttg gcagccgacg gtgaggttgc gatcgtggaa ttcagtgccc
125101 gccgcccgtt tcacccgcaa cgtctgcatg ccgcggttga cctgctgctc gatggcgtgg
125161 ttcgcactcg aggtcggctg tggctggcca accggccgga tcaggtcatg tggctcgaat
125221 cagccggtgg cggtctgcgg gtcgcatcgg ccggaaagtg gttggcggcg atggcggcct
125281 cggaggtggc ctatgtcgac ctggagcggc ggttgttcgc cgacctgatg tgggtctacc
125341 cgttcggaga ccggcacacc gcgatgacgg tactggtatg cggcgccgat ccgaccgaca
125401 tcgtcaatgc cctgaacgcg gcgctgctca gcgacgacga aatggcatct ccgcaacgct
125461 ggcagtccta cgtcgaccct ttcggcgact ggcatgacga cccgtgccac gaaatgcccg
125521 atgcggctgg ggaattctcg gcacaccgca actcaggaga atctcgatga aaccccggta
125581 tccatcccga ctaccagccc gtggtacaga cgccgacact acggctcagc gcgcgctgga
125641 tgctaccgag ggcgtcgata ggttctatcc acccgcgtca gagtcttccg cgtcgtcagg
125701 gcgttcatca ggttgcacga caccgactgt gcttgccaac cacttcggtg ccagcgctga
125761 gactgcggtg gctcctgccg tggcgctgaa gacgcccgtc caggcgaccg gtcccagcgg
125821 ggtacacccg aaaagtggct gataaccggg gtttgaatga tgccgaccaa caccccggcg
125881 ctgcccagtg cggtggcaat gacgagcgga ctgtgccggc gcgtcagcag tgtctgcgct
125941 agctgggtca tcacgagtgc agtcaaaccc attgtcgccg tgcgtcgttc ggttccggga
126001 gtccagcgcc cgatggccca ggctgccgtt gcgccggcgg cggtgacgac gccgcggtta
126061 acgatctgac gcagcaatgg cgcgtccagc gagggcgtag gcccgatcag caccgcacgt
126121 cgatgttcgc gctgcgctcg ctcggccgcg tcatcggttg ggtattcggc gtcgtcgggt
126181 tcggcaaact gcgaggtgac ggccaccgca agcgcgggaa acatgtcggt gagcagattc
126241 accagcagca gttgacgagt ccccaccggc gcccgcccgg ccccgaacgc cgtcccgatg
126301 acggtgaaca gaacttcgcc cacattgccg ccgaccagaa tcgtcaccgc gtcacgaaca
126361 ccggcccaca tgctgcggcc ctcgaccagc gcgtcgagca gcacgcccag gtcatcgtcg
126421 gtcagcacga tatcggcggc cccacgggcg gcagaggaac cgcgcccgct cactccgatg
126481 cccacgtcgg ccatccggat ggccgcggcg tcgttggcgc cgtcgccgac catcgcggtc
126541 actcgcccgc agcgctgcag cgccgccaca atctgaacct tttgttccgg gctgacccga
126601 gcaaagactt gcatgtcggc ggcgagtttg gcatgcgcct cctcgtccag gacggcaagt
126661 tcggcaccgg tcacgactcg cgcgtccgcc ggtagtccca gctggcgggc gatcgcccgg
126721 gcggtgatcg gatggtcgcc ggtgatcagc accacgttgc gctcggcgtc cagcaaggct
126781 tcgatcaacg gacgcgagga agaccgggcc gtatccgcca atccgacata gccgatcagc
126841 tcgagatcgt gcgcgacggc gtcgacagcg tcggcgtcgg tctcgtcatc atgggtggtc
126901 ccgttgtccc aggtgcgctg cgcgactgcc agaacacgca ggccctgctc ggcgaggtgg
126961 cgtaccacgg attcggcatg ttcgtggtcg acgcccgggt cggcgagtcg gcagcgcggc
127021 aggatcgtct ccggagcgcc cttgagcatc aacatcggta tcccgtcggt gcccactctg
127081 ccgatcgcgg cggcgtagcc gcgactggac tcaaacggta cttcggccag caccacccac
127141 tccgaatcgc cttggctact aagcgaaccg gccagcgcac tagccgccgc gaggatcgcc
127201 tcatcggtgg cgtgcgcgtg cccttccccg ttatggggct gcgtggacgc gcgcgcggcg
127261 gcccgcagca cctcggcgga gggcgcatcg gtggtctgcg gcaacggatc ccgttcggct
127321 gcggtgctgc tcggtagcgc gcataccacc cgcaggcggt tctcggtgag tgtgccggtc
127381 ttgtcgaaac atatggtgtc gacacggccc agcgcctcga tggtgcgagg cgagcgcacc
127441 agcgccccac gtgccgtcag gcgctgggcg gcggcaagct gggagagggt ggccaccaac
127501 ggtagaccct ccgggaccgc ggccaccgcg atggcgacgc cgtcggccac cgcttgccgc
127561 agcgacgccc ggcgcagcaa cgccagagct gtcaccgcgg cgccgccggc caacgtcatg
127621 ggcagcactt tgctggtcag ctcgcgcagc cgggcctgga ctccggccgc cgtttcgaca
127681 tcggcgaccg ccgagatcgc gcgatgtgcg gcggtgccga ctccggtggc taccacgatc
127741 gcgcgggcgt gtccggcgac gatggtgctg ccctcaaaca gcatgctggc ccggtcgggg
127801 tcgttgacgg cgacggggtc cacctgcttg tccaccggta gcgactcgcc ggtaagaaag
127861 gactcgtcga cctcgaggtc ttcggccacc agcaggcgcg catccgccgg gaccacctcc
127921 ggcgcggcca ggtcgatgac atcgccgact cgcagcgact tcgccgacac cgtggccgtc
127981 cgggtggcgt gccgggccgc ctccagtcga cgtcgggtag tcgctaccgc cggcaccacc
128041 acccggcgca ccagctggtc ctgctcggcg aatagctcgg cggccgccgc ctcggctcgc
128101 aatcgttgta ccccaccggt gatcgcgttg accgtcatca cgcccgctac cagtagcgcg
128161 tcgatattgc tgccgacaat cgccgatgct gcggcgccca ccgccaggat cggagtcagc
128221 ggatcggcca gttcatggcg ggtggccacc gccagctgcg ccaaggttcg tgccgggccg
128281 cgcagcggcg ccatcaccgg ttcgtaggac aggtcgtcca gaatgcgccg ccaggccggg
128341 attccgggtt cgacggccaa gggtcgggag ccgccggcta gccgcgagta gacgatctcg
128401 gggtccagcg cgtgccaggc ggtcagcggt tgcggggtgg ggtcgggcat ccgcagcacc
128461 ttggcggccg accacattcc ggacaccaaa gccgttgcgg cagcggcatt gaccggattg
128521 agccagcgac ggaagctggc tgggttggtg gttttgtcct gctcaccggt gaccaacaac
128581 agcccggcca aggtggtgcc accttgggcg aggtgtaccg cggattcact ggctgcccgg
128641 gccaccggaa gcgctgacag gatccgcacc gccgcggcca gatcggtgcc ggtgattagg
128701 tcggcagtcc atggtgttgc cccgcgggga tcgtcgagag ccacaccgac gtcagcgatg
128761 gccaacgcgg ccaacgtatc ggtggatgcg aagtcccggt gcaccgcggt gatcagcaat
128821 accggtccgc gatccgcgcg caactcacgc accaacttca gcaacggcgt gccaggcgga
128881 tgcgtcgaac cgacgctggc cgatagatct tcggtgcccg cgacatggcg caaaaccacc
128941 cgcgctccgg ttcggtgcgc ggtctgcagc agcgggattg cgtatgggtc gacttcccac
129001 cccacgtcga cgctgcccac gcattggcca tcgaccacca ggtcggcatg ctcgaggccc
129061 tgagccggcg ttgccgacgg cccttgagcc ggagcccatc tcaagcgggc accggtagcc
129121 ggcaattcat cggggtcggg ttcgggtgcc tgctcgccat ggagcaaggc gtcggcgacc
129181 tcgtagacgc ggtcgtcgtc ccagccgggt tcgtctccct gtgcatgcaa tacggcgcgg
129241 ttgtcaccgc gcagcgctgc gccgtcgata acgaccaccc gcacccgatc caggcggcgc
129301 aacgcgccgg ggtcgaggac tagttgcccg gtgttggcga gcccgcgacc cagcaccgcc
129361 gcgaacgcct gtcggcccat gtgcgcggca cgtggtactc cggccaggat cgcgccggcc
129421 gcgtcctcgg taccaccgcc ggccaccagt gcactggccg cggcgatcaa cgaaccgttt
129481 gcggcctggt tgacgtattg ctccaccggc ccggcccttg accctttggc ggtgtcgatc
129541 gcggcgtcga tggatccgcc gaccacgacg tgcgaagcct cgcctgccgc cgcagccgcc
129601 caactgtgtc gcggctcctg cgatttggcc ccggccgacg agatgatggg caccaccgga
129661 gcctgcggcc gtctggggga ggccagcgcg ggttcgcggt cacgccatac gcgacggtgc
129721 gccgccgctt cggagatttg caggctgcgt tgcaccagat cgagcagcgg tgtgcccagg
129781 gactgggtta gcccgttggc cgccgccgtc gtagcggcga gcgcaatatc ggtgcccact
129841 cgacccaacc gcgactccat aagcgacacc attcgcggtt gatggtttat cagagcggcc
129901 agggctctgg tggtttgcgg tgcggcgggc agtcgggcga cccagccggt gaccgtggca
129961 cccatcgcta ccagatccat tgccgcagcg gtcaacggca ccaggatcgc caaggggtta
130021 cctgggtcgg cgaatggtgc cgagttcggc gacgacaccg acccagccag gaatatgtcg
130081 gcagccaccg cggaaaccac atcacgtacc tcgtccacgg cgatgtcgct atccgcatca
130141 ggttcaagtt cgaccaccag ccgacccaat gagccctcaa cgtgggcctc ggccacgccc
130201 gggatcctgc ggactggctc ctccaccatg gcggcatgct cgtgccagcg agggaatggc
130261 agtagcggat ccaggtcgaa atgcacgcgc cgtccgctgc gccaacgcac cggcggtgtc
130321 attccgtcag gcgattcgtt gtgggaaccg cgtaccccga ttgcgcgacc agtcgtttgc
130381 accaccgact gcaccaccgg gccggtcagc tccagcaccg ggctggccag cgtctgcacc
130441 gccgcggccg cactccccgg caagcgggcg ccggctcgca ctgtctgtgc tactccgttg
130501 gtcacaccac cgaggacagt ggccacaccc gggatcttca ctgagtcacc cttcaactac
130561 cgataccgcg cctaatcctg atggcgtatc agcgccatgt ctaccgactt gcgcatactt
130621 cgccgggtga ggtcgccggt gaaggcagtc cggacccctt tggtctgcga gcgatgaatg
130681 cagacgccgt gtcggatcta gcttgagtac gggcgggccc gtgacgcgcc ggtggcgggc
130741 acgtgaaacc gacccaaacg atcccaacga cgcggcaacg cctggctaac ggctcacgga
130801 tcgaatcagt ggatgcggtg gggtccgtga atcagccggc aagcggccaa gcgttgcatt
130861 gtgcggccga cattgggggg ccgacgaaat cggctcacaa aatgcggtgg tgggccctgc
130921 cgacgtggta acccgccggg aaggacttct cgatgacctg cagctggtgg ttcactctcg
130981 actccagctc gagcaccacg cagctgtcac cgacggtctt cgactcaagg acgatgtacc
131041 gctgaccgcc accgttgaca tcggtgatcg ggtcaccgga gtgcaatgtt tcgacgggca
131101 ccaaatccgg atttccgttt gactccacgc gaaacacagt aaggcaatta agccgactag
131161 ggaacactct gcgtggtgcg ccacctcgac gcggaggcac cagcgggttg gccgcggcgg
131221 gctcgctctt gggtggtcgc cagtgattgt gaccagctgc cggagcggga atgcgtgttg
131281 gacagccgaa tccccgcaat tggcgcaacg tgccccggaa gccgcgctac atttggctcc
131341 tagccaccag acagcttgcc cgaaaacggc agaggtccct gatgtcgctt ttgatcacat
131401 caccggcgac ggtggctgcg gcggcaacac atctggcggg tatcggatcg gcgctcagca
131461 cagccaacgc ggcagcggcc gctccgacga cggcgctatc ggtcgcgggt gccgatgagg
131521 tctcggtgct gatcgcagcg ctattcgagg cgtacgccca ggagtatcag gcgctgagtg
131581 cccaggcact ggcgttccac gaccagttcg tgcaggcgct caacatgggt gcggtttgct
131641 atgcggccgc agagacagcc aacgcaactc cgctgcaggc tctgcagact gtgcagcaga
131701 acgtcctcac cgtggtcaac gcgcccaccc aggcattgct aggtcgacca atcatcggca
131761 acggtgccaa cgggttaccg aacaccgggc aagacggtgg gcccggcggg ttgctgttcg
131821 gcaacggtgg caacggcgga tccggcgggg tggatcaggc cggtggtaac ggcggtgcag
131881 ccggcctgat cggtaacggc gggtccggcg gcgtcggcgg gccggggata gctggcagtg
131941 cgggcggggc gggcggcgcc ggtgggctgc tgttcggcaa cggcgggccc ggcggggccg
132001 gtgggattgg caccaccggt gacggtgggc ctggcggtgc cggcggtaac gccatcggtc
132061 tgtttggcag cggaggtacc ggcgggatgg gcggcgtcgg cggcatgggc ggtgtcggca
132121 acggcggcaa cgcgggtaac ggcggcaccg ccggactgtt cggtcacggc ggggccggcg
132181 gtgccggggg catcggcagc gccgacggcg ggctcggtgg tggcggcggc aatggccggt
132241 tcatgggcaa cggtggggtc ggcggtgccg gcggctacgg cgctagcgga gacggcggaa
132301 acgccggcaa cggcggcttg ggcggcgtgt tcggcgatgg cggggccggt ggtaccggcg
132361 gtctgggtga cgttaacggc gggcttgccg gtattggcgg taacgccggg ttcgtccgca
132421 acggcggagc cggcggcaat ggccagctcg gcagcggcgc agtctcctcg gcgggtggga
132481 tgggcggcaa cgggggcttg gtgttcggca acggcggccc cggcggtcta ggcgggccgg
132541 gcacgtcggc cggcaacggc ggtatgggcg gcaacgctgt cggactgttc ggccagggcg
132601 gggccggcgg ggccggcggg tccggattcg gggccggtat tccaggtggc aggggcggtg
132661 acggcggtag cggcgggctg atcggcgacg gcggcaccgg tggcggtgca ggcgcgggtg
132721 acgctgctgc atcggccggt ggtaacggtg gtaacgcccg gttgatcggg aacggcggtg
132781 acggtggccc gggcatgttc ggcgggcccg gcggagctgg cggcagcggc ggcacgatat
132841 tcggcttcgc cggaaccccc gggccgagct aggcgtgttg catcccgccc aacggcgcag
132901 gcaacaatgg tgcgatgagt ggcgccagct catcggagtc gcccacctgc tatcgccatc
132961 ccgggcgccg gacctacgtc cgctgcaccc gatgtgatcg gtacatctgt ggcgaatgta
133021 tgcgcgtggg tcccgtcggc caccagtgcg cggagtgtgt gcgcgaaggc gcccgggcgg
133081 tgcggcagcc tcgtacccca ttcggcgggc ggcagcggtc ggcaactccg gtggttacat
133141 acacgctgat ctcgctgaat gcgctggtgt tcgtcatgca agtgaccgtg atgggtctgg
133201 aacggcagct cgctttgtgg ccacccgcgg tcgccagcgg tcagacctac cggttggtga
133261 cctcggcgtt cctgcactac ggggcgatgc acctgctgtt gaacatgtgg gcgctgtatg
133321 tggtgggtcc gccgttggag atgtggctgg gccggttgcg gttcggcgcg ctgtatgcgg
133381 tgagcgcgct gggtggctcg gtgttggtct atctgatcgc accgcttaat acggcgacgg
133441 cgggggcatc gggggcggtg ttcggtcttt tcggtgccac gttcatggtg gccaggcggc
133501 tccaccttga tgttcgttgg gtcgtcgcgc tcatcgtgat caacttggct ttcacgttcc
133561 tcgcgccggc gatcagctgg caggggcacg tcggcgggct ggtaacgggt gcgctggtgg
133621 cagcgaccta cgtctacgcg cccagggaac gtcggaactt gatccaggcc acagtgacga
133681 tcaccgtttt ggttgcgttc gtcgtgctga tcggctggcg cacagtcgat ttgctcgcac
133741 tgttcggtgg gcgcctcaac ctgagctgaa cacatcaaaa ccgatagccg cttgtcttcg
133801 cgtgtcttcg gggaatccga cgcggtcaca tctaaactcg ccacgatcaa gaggaggggc
133861 agcgacgtat cggcagcaag cactgcgccg gacgacgaag tggtcagggc gcgctaacag
133921 cgagagctga gccgggcggg attcactccg tgccggcacg ttctgttccc cggccccgtt
133981 gggtggcccc ggtgcgccgg gtcggtcggc tggccgtatg ggatcggccg gagcggcgca
134041 gcggaattcc agcgttagat ggccttcgtg cgatagcggt cgcgctggta ctcgccagcc
134101 atggcggcat ccccggtatg ggcggcgggt tcatcggcgt cgacgccttc ttcgtcttga
134161 gcggatttct catcacctcg ctgctgctcg acgagctggg gcgcaccggt cgtatcgatc
134221 tgagcgggtt ctggattcgc cgtgcgcggc ggctgctgcc ggcgctggtg ctgatggttc
134281 tcaccgtgag cgccgcacgc gcactatttc ctgaccaagc tctcaccggg ctacggagcg
134341 atgcgatcgc cgcgttccta tggacggcga attggcggtt tgtggcccaa aataccgatt
134401 acttcaccca gggcgctcca ccctcgcccc tacagcacac ctggtcgttg ggggtggagg
134461 agcagtatta cgttgtctgg ccactgttgc tgatcggggc gacgctactg ttggcggccc
134521 gggcgaggcg ccgttgcaga cgggccacgg tgggcggggt tcggttcgcc gcgttcctga
134581 ttgccagtct cggcacgatg gcttccgcca ccgccgcggt cgcatttacc tcggcggcca
134641 cccgcgaccg gatttacttc ggcaccgata cccgtgcgca ggcgttgctg atcggctccg
134701 cggcagcggc tctgctggtg cgggattggc catcgctgaa ccgcgggtgg tgcctgatcc
134761 ggactcgctg gggacggcgg attgcccgtc tgttgccgtt cgtcgggctg gctgggctgg
134821 cggtgacgac tcacgtcgca acgggcagtg tgggcgagtt ccgccatggt ctgctgatcg
134881 tggtggcagg tgcggccgtc atcgtggttg cctcggtagc catggagcag cgcggagcgg
134941 tggcccgcat cctggcctgg cgaccgttgg tgtggctggg caccatatcg tacggcgtct
135001 atctgtggca ctggccaatc tttctggcgc tcaacggcca acgtacgggc tggtcgggcc
135061 cggccctgtt tgccgctagg tgtgcagcca cggtggtgct ggccggtgcg tcgtggtggc
135121 tgatcgagca acctattcgg cgctggcgac cggcacgggt tccgctgttg ccgctggcag
135181 cggcgaccgt tgccagcgct gccgccgtga cgatgctcgt tgttccggtc ggagccggac
135241 cggggctacg cgagatcggc cttccgcccg gcgtttcggc ggtcgccgcg gtctcgccgt
135301 cgccgccgga agcgagtcag cccgcgcccg ggccacgaga tcccaaccgg ccgttcaccg
135361 tttcggtatt cggtgattcg atcgggtgga ctttgatgca ttacctgccg ccgactcccg
135421 gattccggtt catcgaccac accgtcatcg gctgcagcct ggtacgcggc acaccgtatc
135481 ggtacatcgg tcaaaccctg gagcagaggg cggaatgcga cggctggccg gccagatggt
135541 cggcgcaggt caaccgggac caaccggacg ttgcgttgct gatcgtcggc cgctgggaga
135601 cggtagaccg ggtcaatgag gggcggtgga cacatatcgg cgacccgacc ttcgatgcgt
135661 acctcaacgc cgagctacag cgagcgctca gcatcgttgg atccaccggg gttcgagtga
135721 tggtcaccac cgtgccctac agccgcggcg gcgaaaagcc ggacggccgc ttgtatccgg
135781 aggatcaacc cgagcgtgtg aacaaatgga acgccatgtt acataacgcc attagccaac
135841 actcgaacgt cggaatgatc gacctcaaca aaaagctttg tccagacggc gtttacacgg
135901 ccaaggtcga cggcatcaag gtccgcagtg atggtgttca tctcacccag gaaggcgtga
135961 agtggctgat accgtggctt gaggattcgg tgcgggtcgc cagttaatcc gccgtgtgct
136021 ccggatgagc gcgacggtaa ccctggaatt gtgctgtgtg ctggctgtgt cgttgtgatg
136081 agcctgtcta agtggtgcgt aaccgtttga cgagccgcgg cctcgctgca aacattgaag
136141 cccgcacgtc tgggtttgta tttacacaac gagggcgctc cccgatctgg cgcgcgcaac
136201 gaggtgcgca ctatccattc gaggtgaact ggactccttg atgctcaggc cggtgcggtt
136261 tgtcgagaaa ggcgaatagg aacagtccat gaaagtgtgg atcactgggg ctggcggaat
136321 gatggggtca catctcgccg aaatgttgct ggccgccgga cacgatgtgt acgctaccta
136381 ctgcaggccg accatcgatc cgtcggacct gcaattcaac ggagcagaag tcgatatcac
136441 cgactggtgc tcggtctacg attcgatagc gacattccgc cccgacgcgg tatttcatct
136501 cgcggcccaa agctatccgg cggtttcgtg ggcccggccg gttgagacgc tgaccaccaa
136561 catggttggc accgccatcg ttttcgaagc actacgtcgc gtgcgaccgc acgcaaagat
136621 tattgttgcg ggctcgtcgg ccgaatatgg atttgttgac ccatccgagg ttccgattaa
136681 tgagcggcga gaacttcgcc cgctccatcc gtatggtgtt tctaaggcgg ccaccgacat
136741 gctggcgtat caatatcaca agtcttacgg catgcacacc gtcgtcgctc gtatcttcaa
136801 ttgcaccggg ccacgcaaag tcggagatgc actttccgat ttcgtccgcc gttgtacatg
136861 gttggagcac catccggaac aaagtgccat ccgggtggga aatcttaaga cgaaacggac
136921 tatcgtggac gtccgcgatc tcaatcgggc gttgatgctg atgctggata aaggcgaggc
136981 cggggctgac tacaatgtgg gaggttcgat cgcctacgag atgggcgacg ttctcaaaca
137041 agtaatcgcg gcttgtaaac gtgacgatat cgtgccggaa gtcgaccccg cccttcttcg
137101 gcccaccgac gaaaagatca tctacggaga ttgcagcaag ctggcggcca taacaggctg
137161 gcaacaagaa atctgtttga ctcagacgat tgccgacatg ttcgattatt ggcgtagcaa
137221 atccgagtcc gccctgatgg tgtgaccgaa tgtctttgtc ctgccaacct gaggagcaga
137281 taagattgac cgtaacggac tctcagtatc gacaaaaggt gtgcaccgcg agaactgctg
137341 aggagatctt tgtagagaca atcgctgtca agacacgcat cctcaatgac cgggtcttgc
137401 tggaagccgc tcgcgcaatt ggggaccgct tgattgccgg ctatcgtgcg ggagcacgcg
137461 tcttcatgtg tggcaacggt ggtagcgctg cggatgcgca acattttgcc gcggagctaa
137521 cgggtcacct gatctttgat cggccaccgc ttggcgccga ggcactccac gccaattcgt
137581 cgcacctaac agcggtggcc aacgactatg actacgacac cgtttttgcc agggccctcg
137641 aaggatctgc gcgtcccggc gacacgcttt ttgcgataag tacctccggc aattctatga
137701 gtgtactgcg ggccgcgaaa accgcaaggg agttgggtgt gacggttgtt gcaatgacgg
137761 gcgaatccgg cggccagctg gcagaattcg cagatttctt gatcaacgtc ccgtcacgcg
137821 acaccgggcg aatccaggaa tctcacatcg tttttattca tgcgatctcc gaacatgtcg
137881 aacacgcgct tttcgcgcct cgccaatagg aaagccgatc cttacgcggc cattcgaaag
137941 atggtcgcgg aacgtgcggg acaccaatgg tgtctcttcc tcgatagaga cggggtcatc
138001 aatcgacaag tggtcggcga ctacgtacgg aactggcggc agtttgaatg gttgcccggg
138061 gcggcgcggg cgttgaagaa gctacgggca tgggctccgt acatcgttgt cgtgacaaac
138121 cagcagggcg tgggtgccgg attgatgagc gccgtcgacg tgatggtgat acatcggcac
138181 ctccaaatgc agcttgcatc cgatggcgtg ctgatagatg gatttcaggt ttgcccgcac
138241 caccgttcgc agcggtgtgg ctgccgtaag ccgagaccgg gtctggtcct cgactggctc
138301 ggacgacacc ccgacagtga gccattgctg agcatcgtgg ttggggacag cctcagcgat
138361 cttgaattgg cacacaacgt cgccgctgct gccggtgcat gtgccagtgt ccagataggg
138421 ggcgccagtt ctggcggtgt cgctgacgcg tcatttgact cgctctggga gttcgctgtc
138481 gcagtcggac atgcgcgggg ggagcggggc taatggcgat cttgcgcggg cgagcgccgt
138541 tgcggctcgg actcggcggt ggcgggacag acgtggaacc gtactcgagc cagtttggcg
138601 gacgaattct tagcgtaacc atcgacaaat acgcctacgc gttcgcggag cgcggaacag
138661 gagatgagat cgcctttcgc tcgccggacc gcgaccgagc cggccaggcc tcgatcgacg
138721 atctggcgtc tctcgaagaa gactttccgt tgcacgtcgc cgtctaccgg cgggtgattg
138781 cggagttcaa cggtggtaca ccgtttccgc tccagctggc gacgcaggtg gacgctcctc
138841 ccgggtcggg gctgggctcg tcgtctgctt tggtggtggc gatgcttctc acgacatgtg
138901 cgctcatcgg ctcgtcgccg ggcccatacg agctggcgcg actggcctgg gaaatcgaac
138961 gggttgatct cggcatggcc ggtggttggc aagaccacta cgccgcggct ttcggcggct
139021 tcaacttcat ggagtcccgc cccaacggag aagtcgtggt gaatccgctt cggatacggc
139081 gggaggtgat cgccgaactg gaagcttccc ttcttctgta cttcggcggc gtctccaggc
139141 tgtcgtcgga agtcatcgcc gatcaacaac gcaatgtcgt cgagcgagac gcggacgcgc
139201 ttgcggccac tcactcgatc tgcgccgagg cactcgaaat gaaggatctt ctcgtggtgg
139261 gtgacatacc cggcttcgcc gattcactgc ttcgcggctg gcaagcgaaa aagcggacgt
139321 caacccgaat ctcgaacccc gcaatcgagc acgcttacca ggtcgcgcag tccagcggca
139381 tggtcgccgg gaaagtctcg ggtgccggtg ggggtggctt cctcatgatg atcgtggacc
139441 cgcgtcgccg tatcgaagtc gcacgcagcc tcgaacgaga gtgcggagga tcggtggctc
139501 cttgcctgtt taccaaaggc ggagcggtga cctggcatat cccagagtcc acggcacccg
139561 taaggcgtgg agttgctgat gccgtggctt cagcgctcgg aaacgctgga atcttgctgt
139621 gtgctggctg tgtccttgcg acgagccact cgacttggcg cgtaccggtt tgacgatcgg
139681 ggagcccagt gcaagcatga gaccccgcaa gcaccgggcg ctgacgcctc ttcgtgaggt
139741 gactgagacg acacctccgt gtgtcctggc cgtgaggagg tgagggcgag atgagtccga
139801 gcgacagtcc cgatccgaca ttcgtcttgt cccgatctgg ctccggcatt ctttctgcct
139861 tctgagcttt cgcgagttac tgcgcatgtc cgatgtggcg cagttgtggc gttctgaatg
139921 acgcacgctg atcgggcttc ctgcaggaga agaacatgac cacgatgatc atgacttttg
139981 ttgttccaca acgtgttacc cgtgcgacga aagggcgggc acggtcgctg ctgcgggtga
140041 gtcggcgtct gacggacacg tttcgcgcac cgctcgcctg gaccccgcag gagcgggccg
140101 accggtatgt ggcacgtatg ccgatcgcgg tgattgcgga ctgagcgggc gtcggcgcgt
140161 ggcgcggtta cccgttggac cggcgctagc ccaacccgcg cgcgcgtgtt ggtacaccga
140221 cacgctgtct gggccctaca actgcgcacg ctcgcggcca gtgccgctag ccgaccacct
140281 caatgggatc accaacggtg acggcgtcga agtaccatgc cgcgttgtcc gggctgaggt
140341 tgatacagcc gtggctgacg ttggcgtatc cctgcgagtt gaccgaccag ggggccgagt
140401 gcacgtacac gccgctccag gtaacacgaa ccgcgtagtg ggcggtgagc agatacccgt
140461 ccgaggaatt cagcgggatg ccgatggtac gcgagtccat cacgaccgtg cgctccttgg
140521 acattgcgtg aaagctaccg attggtgtcg ggcggctggg cttgcctaac gacgcgggca
140581 tggtgcggag gacttctccg tttctgctga ccgtgaaggt atgtgccgag atgctggcaa
140641 ccccgatcag tgcgtcaccg gtctcgaatc cttcggtcag ttcctgcaca cccaccgaga
140701 cacgggtgtg aggtggccaa taccggtggg gcacccaccg cacgacattg ctagcgaccc
140761 actcgaagtg tccggtcgtg ttgtgcggtg tgctgatgcg gatggaccgc tcgacggcgc
140821 ggcgatcggt cacgggcgtg gtgaatgtca ccaccaccgg gtgcgccacc cccaccacgg
140881 caccattagc cggcgacacc gacgcaacgc ctgggatcgg ttggagtggc gggaccgcgg
140941 cggtcgctat gctgactgat tccgcggtga gcatcagcgt gatcgcgacc acaacggata
141001 gataacgaac cactcgacgc atggcgtcca ccctcccgag atggtgcgat cgacacacga
141061 cattctagtg accatcgacc cattgcgggc cgagcaagca gtttctggat agccccgccg
141121 ccccgcgggt gcggattggc aggccgcgcg gcctcgcgtt agcctcagcg gaatcggtgc
141181 caaggccgag gaggtgcggg tgctcttccg tcagctggag tacttcgtcg cggtcgccca
141241 ggagcggcat ttcgctcggg ccgctgagaa gtgctacgtg tcgcaacctg cgctgtcttc
141301 ggcaatcgcc aagctcgaac gcgaactcaa cgtcaccctg atcaatcgcg gacacagttt
141361 cgaaggcctt actcgcgagg gtgagcggtt ggtggtatgg gccaagcgga tacttgccga
141421 gcacgctgcg ttcaaggccg aggtggatgc ggtgcggtcc gggataaccg ggacgcttcg
141481 gctaggcacg gttcccaccg cgtcaacgac ggcatccctg gtgctgtcgg cgttttgctc
141541 ggcgcacccg ttggcgaagg tgcaagtctg ttcccggctg gctgcgaccg agctgtaccg
141601 acggctgcgc gaattcgagc tcgatgccgt catcgtgcac cccgagaccc aagacagtga
141661 tgatgttgat ctggtgccgc tctatgagga gcagtacgtg ctgttgtcgc cggcggatat
141721 gctgccgccg gggacatcga cgttggtgtg gcgggatgcc gcgcaactac cgttggcatt
141781 gctcactgcg gatatgcggg accgccaggt tatcgacgcc gcgttcgccg accacgcggt
141841 ctcggcgatc ccgcaggtcg aaaccgattc cgttgcttcg ctgttcgcac aggtggcaac
141901 cggcaactgg gcgtccatcg ttccgcacac ctggctatgg gcaatgccaa tgagcgggcc
141961 gacgggtggt gagatccgcg cggtcgaatt ggtcgatccg gtgctgaaag cccagatcgc
142021 cctggctacc aacgccttgg gaccgggatc tccggttgcc cgagcgctca taacatgcgc
142081 gcaggcgctg gcgctgaacg aattctttga cacgcagctg cgggggatca cccgtcgccg
142141 ctgatcgcgg gcgtcgctgc gctggtagtg ttcagcttcg ccaggtggcc gctctccacc
142201 ccgtctgcag ggtcgagttc gcagtcgatg agtgacggtc cgttcgatgc cagtgcatcg
142261 gtcagcgccg actccagttc ggttggggtg cttacgtgat atcctttgcc gccgaacgcc
142321 tctgcgatca gttcgtgacg tgcatgagcg ttcagcacgg tgggcgctgg gtcgtgtcgc
142381 cacaccgggg cggccgacct aaagatcgtt gcctcgtcgc cgcggtagac gccgccgttg
142441 ttgaggatga cgacggtgac cgggagtcgg tatcggcaga tggtctcgaa ctccatgccg
142501 ctgaagccaa atgcgctgtc gccctcgatc gccacgacag gtcgcccggt ctcgacggcg
142561 gccgcgatgg cgtagcccat gccgatgccc atcacgcccc aggttccgct gtcgagccgg
142621 tgccgcggta ggtgcatgtc gatgatgttg cgggcgaggt ccagcgcgtt ggcgccttcg
142681 ttgaccacat agacatccgg gttgcgttgc agcacagacc taatggcacc aagcgcgttg
142741 tagaaccgca tcggatgatg atcgtcggcc aaccgccgac gcatcttggc actgttgcgg
142801 gccttgcggt cggcgagctc gccggtccac gccgccgagg ccacgctcga acgatcggcc
142861 gcagcttcga ggagcgccga cattaccgag ccgatgtcgc cggtcagcgg tgccacgatc
142921 ggccggttgc tgtcaaactc cgacgcctcg atatcgacct ggatgaactt ggcatcggcc
142981 gaccattgcg gcgactctcc gttgcctagt agccaattca gccgagcgcc aaccagcagc
143041 accacgtcgg cgcgggccat cgccagcgaa cgagccgcag ccgccgactg cgggtgtgag
143101 tcgggcagca gccccttggc catcgacatc ggcaggaagg gaatgccggt gtgctccaca
143161 aactcccgaa taacgttgtc ggcctgcgca tatgccgcgc ccttgctgag cacgagcagc
143221 ggtcgctgcg cttgggcgag cacgtccagc gcgcgatcaa tcgcctccgg tgccggcagt
143281 agtcggggag ccgggtccac cggccgccaa atggcgccgg aagcagccga tgcctcaacg
143341 gcctggccca gcacatcgcc ggggatatcg aggtatacac cgccgggccg cccggaggtc
143401 gcggtgcgaa tggcgcgcgc gacgccgcgc ccgatgtcct ggacttggcc gatccgatac
143461 gccgccttca cgaacggtcg agcggcgttg agctggtcga ggtcctgata gtcgccgcgc
143521 tgcaggtcga ccatcggccg gctgctcgat ccggagatct ggatcatcgg gaagcagttc
143581 gtggtggcgt tcgccagcgc gggcaggccg ttgagaaagc cggggccgga cgtcgtcaga
143641 cacacgccgg gccgtgcggt gaggaacccc gcggcggccg ccgcattgcc cgctgatgct
143701 tcgtggcgga aaccgatata gcggatcccc gaggcttggg cggcgcgagc caggtcggtg
143761 atcgggatgc cgacaacgcc gtagatggtg tcgacgtcgt tggctttgag ggcgtccacc
143821 accaggtggc agccgtcggt cagcactgtg cagggagatg ccgatcgtgt ggtcatggtg
143881 ttcactgttg tccggggcgc cggccgtgtc caagaccgag tcactatgca gcgatttacg
143941 cggtctatca accgttagcg gatcggtatt ggacgccggg caggcgagcc cggcactgtg
144001 ctgatcgtgc cgaacccgca caccgaacac atggaaggag cgttcgcgat ggcatccgac
144061 ttcggcccgc gcatcgccga tcttgtcgag gtggcggcga cccggctgcc cgaggctccg
144121 gcgctcgtcg tcaccgcgga tcgcatcgcg atcagccacc gcgacctggc ccgtctggtt
144181 gatgagctgg ccggccagct gacgcggtcc ggcctgctgc ccggtgaccg ggtcgcgctg
144241 cgcatgggca gcaacgccga attcgtcgtc gccttgctgg cggcgtcgcg tgcggatctc
144301 gtcgtcgtgc cgctggatcc ggcgctgccc atcaccgagc aacgcgtccg aagccaggcc
144361 gcgggagccc gggtggtgct gattgacgcg gatgggccgc acgacagggc agaacccacc
144421 acccggtggt ggccgctcac ggtgaacgtc ggcggtgaca gcggcccctc gggtggcacc
144481 ttgtcggtcc acctggacgc cgccaccgag ccgaaccccg caacctcgac gcccgaggga
144541 ctgcgacccg atgacgccat gatcatgttc accggcggga cgaccggcct gccgaagatg
144601 gtcccctgga cgcacgcaaa catcgccagc tcggtccgcg ccatcatcac cgggtaccgg
144661 ctgagcccgc gggacgccac cgttgcggtg atgccgctct accatggcca cgggctgatc
144721 gcgtcgttgc ttgccaccct ggcgtccggc ggcgcggtgt cgctgcccgc acgcgggcga
144781 ttctccgcgc acaccttctg ggacgacatc aaagccgttg gagccacctg gtatacggcg
144841 gttccgacga ttcaccaaat cctgctggag cgatcggcaa ccgaaccgtc ggggcgcaaa
144901 cctgccgcac tgcgtttcat ccgcagctgc agcgcaccgc tcactgccca agccgcgcta
144961 gcactgcaaa ccgagttcgc ggcaccggtc gtgtgtgcct tcggcatgac cgaagccacc
145021 caccaggtaa cgacaacgca gattgagggt atcgaccaaa ccgaaactcc cgtcgtgtca
145081 accggtctgg tcggccggtc gacgggagcg caaatccgga tcgtcgggtc cgacgggctg
145141 ccactgcccg cgggcgcggt cggggagatc tggctgcggg ggaccaccgt ggtacgcggg
145201 tatctgggtg acccgacgat aaccgccgcg aatttcaccg acggttggtt gcgtaccggt
145261 gatctcgggt ccctgtcggc ggccggtgac ctgagcatcc gcggccgcat caaggaactc
145321 atcaaccgag gtggtgaaaa gatctcgccc gagcgcgtcg agggcgtgct ggccagccat
145381 ccaaacgtca tggaggcagc cgtattcggc gtcccgcacc agctctacgg cgaggcggtc
145441 gcggcggtga ttgtgcctcg tgagtccgcc ccgccgactc gcgaggagct tgtccagttc
145501 tgccgggaac ggttggcggc cttcgagatc ccggcctcct tccaggaggc cagcgggctg
145561 ccgcacaccg cgaagggttc gctcgaccgc cgcgctgtcg ccgaacggtt cggccattcg
145621 gtgtagctag ccggccccgg cctttacccg ggcggcggcg gattccggca tcggttcgta
145681 gcgggcaaac gaacgggtga aggatgcggc cccatgcgcc agcgagcgca aatcgattgc
145741 gtagcgggtc agctcgacct gaggcacctc ggccttgatc accgtgcggt cgtgccccgc
145801 ggtctcggtg ccgagcactc ggccacgacg actggacagg tcgcccaaca ccgcgccgac
145861 gaaatcgtcg ggtaccagca ccgaaatctc atcgattggc tcgagcaaga tcaccttcgt
145921 cgcggccgcg gcctcccgca atgcgagcgc gccggccatt tggaaggcga aatcggaaga
145981 gtcgacgctg tgggctttgc cgtcgagcaa cgtgacccgg atatcgacca ccgggtagcc
146041 ggcgtgcact cccttatcca tctgtgcgcg gacacctttc tccacattgg ggataaactg
146101 ccgcggcacc gccccgccaa ccactttgtc gaggaactcg aacccggagc cctccggcag
146161 cggctccacc tcgatgtcgc acaccccgta ctgaccgtga ccaccggact gtttgatgtg
146221 gcggccatgg cctttcgcat tgccggcgaa ggtttcccgc agcggcaccc gcagctcgat
146281 cgtgtctacg ctgacgccgt accggttggc cagtgtatcc aggacgacgc cggcatgggc
146341 ctcgcccata caccacagca cgacctgatg ggtctcttga ttttgctcga tccgcagtgt
146401 cgggtcttcg gcggccaacc ggcccaaccc gaccgacagc ttgtcttcgt cggtcttggc
146461 atgcgccgca atggcgatcg gcagcagcgg ctcgggcatg gtccagggtt tcagcaccag
146521 gggctcggcc ttatccgaga gtgtgtcccc ggtctcggcc cggctcagct tgccgatggc
146581 gcagatgtcg cccgcgacca cggctgctgc cgggcgctgt tgcttgccca gcgggaacga
146641 caagactccg atgcgctcgt cttcgtcgtg gtcggggtgc gtgttactag ttccgccgcc
146701 gaaaaacgat gagaaatggc ccgacacatg gaccgtcgtg tcgggcctga tggttccgga
146761 gaacacccgc accaagctga cccggccgac gtaggggtcc gacgtcgtct tcaccacctc
146821 ggcgagcaac ggcgcgtcat tgtcacaggc cagctccgca tgcgggacac cctgcggggt
146881 aaagacctcc ggcagtgggt gctccatcgg agacggaaat ccgcgggtgg ctacctcaag
146941 caattccagt gtgccgaccc cggtgctgct gcacaccgga atcaccggga agaacgagcc
147001 tcgggcgacg gctttctcca gatcctggat cagcaccgac tcgtcgatcg tctcgccgcc
147061 gaggtagcgc tccatcaagg actcatcctc ggattcctcg atgattcctt cgatcaaggc
147121 gccgcgcgcc tcctcgattc gctcggtgtc cgactcggcc ggggttcgtg tcgttcgctt
147181 gccgtcggcg tactcgtaca gtgcctgcga aagcaatccg atcaggccgt caccggacgg
147241 caggtagagc ggtaagacct tgtcgccgaa ggcgtcttgt gccgcggtca gcgcttcccg
147301 gtagttcgcc cgggcgtggt ccagcttggt gatgaccacc gcgcggggca tgccgacctg
147361 gctgcattcc tgccacaggg acttggtcgg ttcgtcgacg ccctcgttgg ccgcgatcac
147421 gaacagtgcg caatcggcgg cccgcaaccc ggcccgcagc tcacccacga agtcggcgta
147481 cccaggggtg tcgacgaggt tgaccttgat gccgtcgtaa gccagcgagg cgaccgcaag
147541 gcccaccgag cgctgttgcc ggatctccgc ctcgtcgaag tcgcagaccg tggtgccctc
147601 ggtgaccgag cccggcctgg acaacacctt ggccgccacc aggagagcct cgatgagggt
147661 ggtcttgccg ccccccgagg gccccaccag aaccacgttg cgaacgccgc cgggcccgtt
147721 tgcggtggga gcggcggccg cgccctggga agcattcact ctgtcggcca tggctttcct
147781 ccagttctcc ggggtcggtt cccgtggtgt ggcccagcag gacgtagtag gcaacttttc
147841 tcccaactgc cgcccagcac aagggtcggg tcaggtgagt agtaggcaat cggagccgtc
147901 gttgtggtca ggcgtgccag ctggcccagc gctggactgc tattgcgatt accgggccgt
147961 tcaacggaac cgattggtat tgagcatatt tggcgcgcag caggcggtat gcggcgcgca
148021 tcacctcgcc atcgcgatga atcgcggcga ccccgtcggc ccggacccac cacaactggg
148081 tccaatcatc ggcatagctg tcgacgagca cgctggcccg tggattgtgc tcgagattgg
148141 cgagccggcg cagccgctgc gtcgttttcc gcttcgcgtc gacggcggtg tagataacgt
148201 ctgcaccggt cgcctcggcc gggcgcctag cgccgagcgc gaatacgacc ggcaccaggt
148261 ggggtgtgcc gtcgggcgtg ctggtggcca gtcgtgcgac gggggactgg gcaaacctga
148321 gctttgggtc gaattccccc acggcgccag cttatgctca gctgccgccc aacgtcgcgc
148381 agtctggacg gccagacgtc gcggccgtga cagcggacat ctcgggcagc ccggtccatg
148441 gggcgtgcgt gctaatggtg ccggtggtaa tccagtggcg cgcaaggtaa ttggccgggt
148501 cggtctcggc cgccgcagga atcggttggg tcggtttgaa cgtgacagag acgaacagag
148561 accagtgcta tcgcgtcgaa cggacgaccg ttgacgcttt gacacatccc gagtatcgag
148621 tacatactcg aggcgtgcag cgggtcaggg tcacgaggaa cgcccggaag caccgcgtgt
148681 ccaagcaccg catcgtcgcc gctatgcgcc actgcggtgt tccggtcatt caggaagatg
148741 gctcgctgta ctaccagggc cgcgatacgt cgggccgtct taccgaggtc gtcgccgtcg
148801 aagccgacga cggtgacctg atcatcactc acgcaatgcc gaaggagtgg aagcgatgac
148861 gaagaagcca cgtaaccccg ccgactacgt gatcggcgac gatgtcgagg tgtctgacgt
148921 cgatctcaag caagaggagg tctatgtcga tggcgagcgg ctaacggacg agcgcgtcga
148981 gcagatggct tcagagtcgc tgcggctggc gcgcgaacga gaagccaacc tgattcctgg
149041 cggcaagtct ctgtccggcg gctctgcgca ctcgccggct gtgcaggtgg tcgtttcgaa
149101 ggctacccac gccaagctca aggagctggc gcgcagccgg aagatgagcg tatctaagct
149161 gctgcgtccc gtgctcgacg agttcgtaca gcgagaaacg ggtcggattc tcccacggcg
149221 ttagcttgtg ctcagccgcc gctcgacgtc gcgaagtctg gacagtcagc tgtcgcagcc
149281 gtgaccagcg gacatctcgg gcagctagcc cgacagggtg cgcgtgcacc tggcccgggt
149341 ggtaatccat tgacgcgcac ggcaattggc cggctcggtc tcggtctgcg gataccgcac
149401 tgaagggcga caattttggc gaaaaggccg tgtgcggtgc cgggtcgcgc tacgttcaga
149461 ttcacctaac aatgtcgtcc gccaacgagc gtgttcgccg gtggtggggc gggcgggttg
149521 gggaggtgtg tgatgtcgtt tgtcagcgta gccccggaga ttgtggtggc cgcggcaaca
149581 gacctggcgg gtatcggatc ggcgatcagc gcggccaatg ccgccgcggc tgcgccgacc
149641 accgccgtgc tggccgcggg tgccgatgag gtgtcggcgg cgatcgcggc gctgttttcc
149701 ggccacgctc aggcctatca ggcgctcagc gcccaggcgg cggcgtttca tcagcagttc
149761 gtgcagacgc ttgccggtgg cgctggagca tatgcggccg ccgaggccca ggtcgagcag
149821 cagctgctgg ccgcgatcaa cgcgcccacc caggcgctgc tggggcgccc cttgatcggc
149881 aacggtgccg atggggcgcc ggggactggg caggccggcg gggctggggg gatcttgtac
149941 ggcaatggcg gcaatggcgg ctccggggcg gctgggcagg ccgggggtgc cggcgggccg
150001 gccgggctga tcggccatgg cgggtccggc ggggccggcg gctccggcgc ggccggcggg
150061 gccggcgggc acggcggatg gctgtggggc aacggcggcg tcggcggatc cggcggggcg
150121 ggtgtcggcg caggcgtggc tggcggtcac ggcggtgcgg gcggtgccgc cgggctgtgg
150181 ggcgccggcg gcggcggtgg caatggcggg aacggcgccg atgccaacat cgtcagcggt
150241 ggagacggtg gcctcggcgg tgccggtggc ggtggcggat ggctctacgg cgacggcggg
150301 gccggcggac acggcggaca aggcgcaatc ggcctcggcg gcggcgccgg cggcgacggg
150361 ggccagggcg gcgccggccg cggactgtgg ggtactggcg gcgccggcgg acacggcggg
150421 caaggcggtg gtaccggggg cccaccgctg cccggtcagg caggcatggg cgccgcgggt
150481 ggcgccggtg ggctgatcgg caacggcggg gccggcggcg acggcggtgt cggcgcgtcc
150541 ggcggggtcg ccggagtagg cggtgccggc gggaacgcca tgctgatcgg gcacggcggc
150601 gccggcggcg ccggcggaga cagcagtttc gctaatggcg cggccggcgg cgcgggcggt
150661 gccggagggc acctcttcgg caatggcggg tccggcggcc acggcggagc cgtcacggcc
150721 ggcaacaccg gtatcggtgg cgccggcggc gtcggtgggg acgccaggct gatcggccac
150781 ggtggcgccg gcggtgccgg cggggaccgc gccggagcct tggttggccg tgacggcggg
150841 cccggtggga acgggggcgc tggcggccag ctatacggca acggcggcga cggcgccccc
150901 ggcaccggcg gaacactgca ggcggcggtg agcggattgg tgacggcttt gttcggtgca
150961 cccggccaac ccggcgacac cggccaaccc ggctagcccc gatcaacgag ggtttcggtg
151021 ccggtccggg gcatggccat ccgctgagct ggcgatctgg actacgttgg tgtagaaaaa
151081 tcctgccgcc cggaccctta aggctgggac aatttctgat agctaccccg acacaggagg
151141 ttacgggatg agcaattcgc gccgccgctc actcaggtgg tcatggttgc tgagcgtgct
151201 ggctgccgtc gggctgggcc tggccacggc gccggcccag gcggccccgc cggccttgtc
151261 gcaggaccgg ttcgccgact tccccgcgct gcccctcgac ccgtccgcga tggtcgccca
151321 agtggggcca caggtggtca acatcaacac caaactgggc tacaacaacg ccgtgggcgc
151381 cgggaccggc atcgtcatcg atcccaacgg tgtcgtgctg accaacaacc acgtgatcgc
151441 gggcgccacc gacatcaatg cgttcagcgt cggctccggc caaacctacg gcgtcgatgt
151501 ggtcgggtat gaccgcaccc aggatgtcgc ggtgctgcag ctgcgcggtg ccggtggcct
151561 gccgtcggcg gcgatcggtg gcggcgtcgc ggttggtgag cccgtcgtcg cgatgggcaa
151621 cagcggtggg cagggcggaa cgccccgtgc ggtgcctggc agggtggtcg cgctcggcca
151681 aaccgtgcag gcgtcggatt cgctgaccgg tgccgaagag acattgaacg ggttgatcca
151741 gttcgatgcc gcgatccagc ccggtgattc gggcgggccc gtcgtcaacg gcctaggaca
151801 ggtggtcggt atgaacacgg ccgcgtccga taacttccag ctgtcccagg gtgggcaggg
151861 attcgccatt ccgatcgggc aggcgatggc gatcgcgggc cagatccgat cgggtggggg
151921 gtcacccacc gttcatatcg ggcctaccgc cttcctcggc ttgggtgttg tcgacaacaa
151981 cggcaacggc gcacgagtcc aacgcgtggt cgggagcgct ccggcggcaa gtctcggcat
152041 ctccaccggc gacgtgatca ccgcggtcga cggcgctccg atcaactcgg ccaccgcgat
152101 ggcggacgcg cttaacgggc atcatcccgg tgacgtcatc tcggtgacct ggcaaaccaa
152161 gtcgggcggc acgcgtacag ggaacgtgac attggccgag ggacccccgg cctgatttcg
152221 tcgcggatac cacccgccgg ccggccaatt ggattggcgc cagccgtgat tgccgcgtga
152281 gcccccgagt tccgtctccc gtgcgcgtgg catcgtggaa gcaatgaacg aggcagaaca
152341 cagcgtcgag caccctcccg tgcagggcag tcacgtcgaa ggcggtgtgg tcgagcatcc
152401 ggatgccaag gacttcggca gcgccgccgc cctgcccgcc gatccgacct ggtttaagca
152461 cgccgtcttc tacgaggtgc tggtccgggc gttcttcgac gccagcgcgg acggttccgg
152521 cgatctgcgt ggactcatcg atcgcctcga ctacctgcag tggcttggca tcgactgcat
152581 ctggttgccg ccgttctacg actcgccgct gcgcgacggc ggttacgaca ttcgcgactt
152641 ctacaaggtg ctgcccgaat tcggcaccgt cgacgatttc gtcgccctgg tcgacgccgc
152701 tcaccggcga ggtatccgca tcatcaccga cctggtgatg aatcacacct cggagtcgca
152761 cccctggttt caggagtccc gccgcgaccc agacggaccg tacggtgact attacgtgtg
152821 gagcgacacc agcgagcgct acaccgacgc ccggatcatc ttcgtcgaca ccgaagagtc
152881 gaactggtca ttcgatcctg tccgccgaca gttctactgg caccgattct tctcccacca
152941 accggatctg aactacgaca accccgccgt gcaagaggcg atgatcgacg tcatccgctt
153001 ttggctcggc ttgggcatcg acgggtttcg gttggacgcg gtgccctatc tctttgaacg
153061 tgagggcacc aactgcgaga acctgccgga aacacacgct tttctcaagc gagtccgcaa
153121 ggtggtggac gacgaattcc ccggccgggt gctgctagcc gaagccaatc agtggccggg
153181 cgatgtcgtc gaatatttcg gtgatcccaa caccggtggc gacgagtgcc acatggcctt
153241 tcacttcccg ctgatgccgc gcatcttcat ggccgtgcgc cgggagtccc gttttccgat
153301 ctcggagatc atcgcccaga ccccaccaat ccctgacatg gcgcaatggg ggatatttct
153361 gcgcaaccac gacgagctga cgttagaaat ggtcaccgac gaagagcgcg actacatgta
153421 cgccgagtac gccaaggatc cacggatgaa ggcgaatgtc ggaatccgtc gtcggcttgc
153481 gccgctgctc gacaacgacc gcaaccagat cgagctgttc accgcgctgc tgctgtcgct
153541 gcccggctcg ccggtcctct actacggcga cgagatcggg atgggcgacg tgatctggtt
153601 gggtgatcgc gacggcgtgc gcatcccgat gcagtggaca ccggaccgca acgcgggttt
153661 ctccaccgcc aacccgggtc ggctgtacct gccgcccagc caggacccgg tttacgggta
153721 tcaggccgtc aacgtcgagg cgcaacgcga cacctcgacg tcgctgctca acttcactcg
153781 caccatgctg gccgtgcgtc gccgacaccc cgcgtttgcg gtcggcgcat tccaggaatt
153841 gggcgggtcc aacccgtcgg tgctggccta cgtgcgtcag gtggccggcg atgacggcga
153901 caccgtgctc tgtgtcaaca acctgtcgcg attcccgcag cccatcgaat tggacttgca
153961 gcaatggacc aactacacgc cggtcgagct gaccgggcac gtggagtttc cacgcatcgg
154021 ccaggtgccc tatctgctga cgctgccagg acacgggttc tactggttcc agttgaccac
154081 acatgaggtg ggggcacctc ccacttgcgg gggagagcgg cgcctatgac tcgcgccggc
154141 gacgatgcac agcgaagcga tgaggaggag cggcgcctat gactcgcgcc agcgacgatg
154201 cacagcgaag cgatgaggag gagcggcgcc tatgactcgg tcggacacgc tggcaaccaa
154261 gctgccatgg tccgattggc tttcgcggca acgttggtat gccggacgca accgcgagct
154321 ggccacggtc aagccgggcg tagtcgtcgc cctgcgacac aacctcgacc tagtcctggt
154381 cgacgtaacc tacaccgacg gtgcaacgga gcgttaccag gtgctcgtcg gatgggattt
154441 tgagccggcg tccgagtacg gcacgaaagc cgccatcggc gtcgccgacg atcgcacggg
154501 attcgatgct ctctacgacg tcgccgggcc gcaattcctc ctgtcgctaa tcgtctcgtc
154561 cgccgtctgt ggcacatcca ccggcgaagt aacgttcacc agggagccag acgtcgagct
154621 gccctttgcc gcgcagccgc gggtatgtga cgccgaacag agcaacacca gtgtgatctt
154681 cgatcggcgg gctatcctca aggtgttccg ccgggtaagc agcgggatca accccgacat
154741 agagctgaac cgcgtgctta cccgtgccgg taatccacat gtggcccgcc tgctgggcgc
154801 ttaccagttt gggcggccca atcgttcgcc aaccgatgct ctggcgtacg ccctgggcat
154861 ggtgaccgag tatgaggcga acgcggccga aggctgggcg atggccaccg ccagcgtgcg
154921 ggacctcttc gccgagggag acctctatgc ccacgaagtc ggcggcgatt tcgccggtga
154981 atcctaccgg ctcggcgagg cggtcgcctc ggtgcacgcc acgctggctg acagcctcgg
155041 aaccgcgcag gcaacgttcc cggtggaccg gatgctggcg cggctgtcgt cgacggtggc
155101 ggtggtgccc gaactgcggg agtacgcgcc aacgatcgaa cagcaattcc agaagctcgc
155161 ggcggaggca atcacggtcc agcgggtgca cggtgacctg cacttgggac aggtgctgcg
155221 taccccggaa agctggctgt tgatcgactt tgaaggcgag ccgggccagc cgctggacga
155281 acggcgagcg ccggattcgc cgctgcgcga cgtggccggt gtgttgcgat cgttcgagta
155341 cgccgcttac gggccgctgg tggaccaggc caccgacaaa caacttgccg ctcgcgcccg
155401 cgaatgggtc gagcgcaatc gcgccgcctt ctgcgacggc tacgcggtcg cgtcgggaat
155461 cgacccgcga gattcggcgc tgctgttggg cgcctacgaa ctcgacaagg cggtttatga
155521 gaccggctat gagacacggc accggccggg ttggcttccg attccgctgc gttcgatcgc
155581 ccgcctgacc gctagctgat accggccggg gtgtccggct tattgcttgg cgtgcgtgcg
155641 tcctgggcgt ctggaagcat gctcgtgtgc aacgagagat ttatgacggt gaggcgcggc
155701 tgtcatgggt gttggcggcg ctggccggga tactgggggc aaccgcgttc acccactccg
155761 cgggatactt cgttactttc atgaccggca attcgcagcg cgcggtgctg ggattgtttg
155821 gggacgacgc gtggatgtct gtcaccgcgt cgttgctgat tctattcttc gtcgccggcg
155881 tggtgattgc gtcggtgtgc cggcggcatt tctgggcggc gcatccccac ggcccgaccg
155941 tgctgaccac cttcagtttg atatttgccg ccggagtcga cattatgctg ggcggctggc
156001 acgagagcat gctcgatttt gtgccgattc tgttcgtggt cttcgggatt ggcgccttga
156061 acacatcgtt cgtcaaggat ggcgaggtat cggttccgtt gagctatgtg accggcacat
156121 tggtcaagat gggccagggc atcgaacgtc acctggccgg cggaaaagtg gaggactggc
156181 tcggctactt cctgctgcac gccagcttcg tgctaggcgc cgcggccggt ggcgccatta
156241 gtatggtcgt caccggaccc cagatgctcg cggtcgcggc ggtagtgtgc gctgcgacaa
156301 ccggctatac ctacctgcac gctgaccggc gagggttggt caatcaaaag cggccccagc
156361 cgggaaagcg gctctttcga gcgctcaggc gaggcgaatt agattcggga acctccacgc
156421 ccgcaaccaa ttacgggtcg agttagcttg gcttccagtg gcgctggcga aggggtgacc
156481 acgccaactt cacccggaag gtccgaccca gtgcggatgt tccacacatc ggcagcagcg
156541 ctggccgttg cgctgctgcc gatgctggct tgctggctca ggcggccggc gcagcagggg
156601 cggccggggg tgtcgcgccg ttgagcacat gctggatatc ggccttcatg gcgaccagct
156661 gctcgttcca gtagggccac gagtgtgttc cgttgggcgg gaagttaaac accccgttgc
156721 gtccaccgtc ggccgcgtag gtgtcccgga aggtctggtt ggtgcgcagg gtgaggcctt
156781 ccaggaactt cgccggtatg ttgtcgccgc cgaggtcgct gggtgtgccg ttaccgcagt
156841 acacccagat ccgggtgttg ttggcgacca ggcggggaat ctgaaccatt gggtcgttgc
156901 gcttccaggc cgggtcgctg gacggacccc acatgctgtt ggcgttgtaa ccgcccgagt
156961 cgttcatcgc caggccgatc agcgtcggcc accagccctc ggacgggttg aggaagcccg
157021 acaacgacgc ggcgtacggg aactgctgcg ggtagtacgc ggccaggatc agcgcggaac
157081 cgcccgacat cgaaagaccc accgccgcgt tgcctgtcgg ggacacgccc ttgttggcct
157141 gtagccaggc gggcatctct ctggtaagga aggtctccca cttgtaggtg tagttctggc
157201 cgttgctctg cgagggctga taccagtcgg tgtagaaact ggattggccg cccacgggca
157261 tgatcaccga caaccctgac tggtagtact cctcgaaggc cggggtgttg atgtcccagc
157321 cgttgtagtc atcctgggcc cgcagaccgt cgagcaggta gaccgcgtgc ggtccgccgc
157381 cctggaactg gaccttgatg tcgcggccca tcgacgcgga tggcacctgc agatattcca
157441 ctggaagacc gggcctagag aatgcgcccg cggtggccgg cccgccgaag gtaccgacca
157501 gaccgtaaac caggacagcc cccatagccg cgatagccag ccggcgcggc agggttgtcg
157561 ctgcgctccg caaccttcgc acctgttcga agaacgtcat agctactacc aatcccaact
157621 ctcatctgcc gcacgacgcg gtcgaatctg ttctgggcga gtgaaacaca ccgaggacgc
157681 tcagttcgaa tgtcgtggcc gcagcgcgag atcgcggttg gctaacgatt cagcgtcggc
157741 ccggacacct tgggcgattg acacacccgg gtcacggctg gctcccgagc ggcgcaacga
157801 ccgcacgcac aacccctatg cttactgccg accagaggag agacccatgc gcaccttcga
157861 gtcggtcgcc gacctggccg ccgccgcggg cgaaaaggtc gggcagagcg actgggtgac
157921 catcacccag gaagaggtca atctgttcgc cgacgcaacg ggtgatcacc agtggatcca
157981 cgtcgacccg gaacgggccg ctgcgggtcc ctttggcacc accatcgcgc acggattcat
158041 gaccctggcg ttgctcccgc gcctgcaaca ccagatgtac accgtcaagg gcgtcaagct
158101 ggcaatcaac tacggcctga acaaggttcg cttcccggca ccagtacccg tcggctcgcg
158161 ggtgcgtgcg acgagctcgc tggtcggtgt cgaggatctg ggcaacggca ccgtgcaggc
158221 gacggtgtcg acgaccgtcg aggtcgaggg atcggccaag ccggcgtgtg tggccgaaag
158281 catcgtgcgc tacgtcgcct gaggcaactc gcggtcagaa ttcggcgatc gcgtgctcga
158341 ggcgttgggc cagccaggcc tcggcgtgcg cgcgccgggt cggaatgtgc tgtgacggga
158401 aaagcgttgt caccggctgg tattcgcgca gcgtacggcg ggcgacggtc atcttgtgca
158461 gctcagtggc gccgtcggcg atgcccagtg actcggctgc cagcatcatc ttgacgaacg
158521 gcatctcgtc ggagaccccg agcgcgccgt gcaggtgcat ggcccgctgc acgacgtcat
158581 gcagcacctg gggcatcgcc accttgaccg ccgcgatgtc gcggcgcacc ttttgatagt
158641 cgtggtgttt gtcgataagc cacgcggtgc gcagtaccag cagccggaac tgctcgatct
158701 ggatccaact atcggcgatc ttctcctggg tcatctgcag atcggcgagc cgcccgtgtc
158761 tagtctggcg cgacagggca cgctcgcaca tcatgtcgaa tgctctgcgc gccagcgcga
158821 ttgtccgcat cgcgtgatgt attcggccgc cgcccaatcg ggtctgcgcg atcatgaacg
158881 cttggccctc gccgccgagc acatgatcgg ccggcacccg gacgtcgtgg tagcggatgt
158941 agccgtggct ggcgtgccgg gtggactcgg ctcccacacc gacgttgcgc acgatctcga
159001 tgcccggggt gtcggccggg acgatgaaca gcgacatctt ctcgtacgta cgggcttccg
159061 gcttggtgac ggccatgacg ataaagaacg acgcatgctt ggcgttggtg gaaaaccact
159121 tctcgccgtt gatgatccag tccccgtttc ccgcggcatc gcgggtcgcc gcggtcacga
159181 acagcccggg atcggaacca ccctgcggct cggtcatcga atagcaggag gtgatctcgc
159241 cgtcgagcag cggtcgtaga tagcgggctt tctgctcgtc ggtgccgaac agcgccagga
159301 tctcggcgtt gccggagtcc ggcgcctgac agccgaacgc cgacggcgcc caccgggagc
159361 ggccgatgat ctcgttgagc agcgccagct tgacctgacc gaagccctgt ccgccgagtt
159421 cgggacgcaa atgcgcggcc cacaacccct ggtctttcac ctgccgctgc agcggccgca
159481 ggatcgccat cgtgtcggcg ttctttttgt cgtaaggatc gagggcgacc agatcgagcg
159541 gttcgagttc ctcggccatg aatttttcga cccaatccag cttggactgg tattgcgggt
159601 cggtttcgaa gtcccacacc gtcggcaacc gttccccggc gcggcgtcgc accggcatcg
159661 ttgatagagc aagaccatcg taggtgcggt ctagcggctt cagcgcagtt cgggcaggac
159721 gttggtgcgg tagaagtcga tggcggtgat cgggtcgtcc tgggggaaat gcaggaaggg
159781 gacggcgccg gcgtcgagaa ccgcttgcac cgcaccgatg tggacgccgg gatcggtacc
159841 gaccgcccaa ttggccagca ctttctcgat cgggttcgac tcggcggcac gctggatctc
159901 gaccggattg ggctggtcga cggccccggc ggtgaatcgc cacaagtcgg cggcgcgggc
159961 ggccgccttg tcgtcgccga cgacggcgaa cagttcggcc cgcttaccca gggtggtggg
160021 atctcgtccg gccgcttgag cgcccgcggc gaacgcggcg agcagcttgg cgtcgttgat
160081 gtcgcgggct tgggcgatcc aaccatcacc gtatcggccg gccagggtgg cgctctgggg
160141 gccgctcgcg gcgacaaaga tcggcggcgg catcgccggc gtgtcgtaga gcttgagctc
160201 gtcggtccga aaatagtggc ccgtgaacga gatccgctca ccgctccaca gctggcggat
160261 cagtacgatg gcctcgatca gccggtcgtg gcgctcgcgg tagttgccga acgtgtcggt
160321 ggcggcttgt tcgttgagcc gctcgccggt gcccagcccc agaaacaccc gtccggggtt
160381 caggatcgcc agcgaggcaa acgcctgagc gacggtggcc ggatggtagc ggtatatggg
160441 acaggtcacc ccggtgccga acaagatgct gctggtgctg ttgcccacca acgccagggt
160501 cagccaggga aacatcgaat ggccctcgtt gtcttgccat ggctgtaggt ggtcgctggc
160561 ccacacatac cggaagccag cttgctcggc ggcttgggcg tgcgccacca gccgatcggt
160621 gcggaattgt tcgtgggata agacgacacc caccccgcgg cttgccggct ctggggtcgg
160681 cgtcggaccg ctgcgcgtgc tgcaaccgcc gcctagccca ccggcgccga tcgcgccgaa
160741 cccggcggcc agaccgaacg tccgccgtga gatgccggtc atcgggctgc actacccgcg
160801 tcgcgctgca gcacaccttc gagagtgcat cctgactcac cgtcggcgcc accggttagc
160861 ctggcgagat gaccccgcag gcacgcccag cgcgcagggc cgatgtccgc gagctgtccc
160921 gcaccatggc ccgggcgttc tatgacgatc cggtcatgag ctggttactg tcgaacgaca
160981 acgcccgcac cgcaaggctg acccggttgt tcgcgacgat tgtccgccac cagcatctgg
161041 ccggcggtgg tgtggaagtg gcccgcggcg cggcgggcat cggcggggcg gcgctgtggg
161101 atcccccgga tcgatggcgg gagtcgcgcc gccagcaact ggcgatgaca ccggggttcc
161161 tgcgggtgtt cggctttcgg acggccaagg cccgcgcggc gctggacgtg atgatgcgtg
161221 tgcatcccga agaaccccac tggtatctgg ccgccatcgg cagcgacccg acggtccgcg
161281 gccaggggtt cggtcaggtg ctgatgcggt cacggctgga ccgttgcgat gccgaacact
161341 gtccggccta cctcgaatcc accaaacccg agaatgtgcc ctactatcaa cggttcggtt
161401 tccgggtgac ccgtgagatc gctctgcccg acgcggggcc gccgctatgg gcgatgtggc
161461 gggagcctcg gtagcggttc ttggcagctg gatcgttcgt ccggccgggt gatcactgcg
161521 cgaccgtgaa tctggcgacg ccgcaccggc gtgtcgcgtc gccagactca cagtcgcggc
161581 aatctctgac cgccggtgcg ctgagatagc tcccgaggtg caaaagtggt gcgcagatcg
161641 tcaggctgag cttgccggga tcgcgtgggt cggcacccgc agccgtcgtc tgccacccaa
161701 tagtgtgtgc gacccgcccg gtacacgcgg aatcaacggg tatgcggttc tggcataggc
161761 ttgtcaggca atgatcgctc tgcccgcctt ggaaggtgtc gaacatcggc acgtggatgt
161821 ggcggaaggc gtcaggatcc acgttgcgga cgccgggccg gccgatggtc cggcggtaat
161881 gctggtgcac ggcttcccgc agaactggtg ggagtggcgc gacctcatcg gcccgctggc
161941 cgccgacggc aaccgggtgc tgtgtcccga cctgcgcggc gcgggctgga gttcggcgcc
162001 ccgctcgcgg tataccaaga ccgagatggc tgacgatctg gctgcggttt tggacggcct
162061 gggtgtggcc aaggtcaagc tggtggccca cgattggggt gggccggtcg cgttcatcat
162121 gatgttgcgc catcccgaga aggtgaccgg gtttttcggc gtgaacaccg tggcaccctg
162181 ggtgaagcgc gatcttggca tgctccgcaa tatgtggcgg ttctggtatc agatccccat
162241 gtcgctgccg gtgatcggcc cgcgggtgat cagcgatcct aagggccgct acttccggct
162301 gttgaccggg tgggtcgggg gcggatttcg ggttcccgat gacgacgtgc gcctgtactt
162361 ggactgcatg cgcgagccgg ggcacgccga ggccggatcg cggtggtatc gcacctttca
162421 gaccagggaa atgctgcgct ggctgcgcgg cgagtacaac gacgctcggg tcgatgtccc
162481 ggtccgatgg ctgcacggca ccggagatcc ggtgatcacg cccgacctgc tggacggcta
162541 tgccgagcgg gccagcgatt tcgaggtgga gctggtcgac ggcgtgggcc attggatcgt
162601 cgagcagcga cccgagctgg tgctcgaccg ggtgcgtgcg ttcctagctg cggggaccga
162661 gcagcgcgat tgacgcatcc accgccggct cgacgatgtt ccggatcggc tggccgtcct
162721 cgacggtcag cgcggtcagt tcacgcaaac cgcccagcaa gattacggcc agtggcacat
162781 tcagtggcgg taggttagcc cgccggaacc cagggctggc gctgagctcg atcagcaggc
162841 tggttagctg ctccatgccg cggcgctgga cggggtaagc ggcggcaccg agcgacggga
162901 attcacggat ccaactcaac gtcaccgccg gcctggattc gatatgggtg acgtaggcct
162961 cgaccgcctg acgaatctgg tcgtgccagt cggcgtttgg atcgacggcc gcccggatgc
163021 tgttgcccaa cgtctcgttg tccgctagca ggagttccaa aaagcactgt tccttgctgg
163081 tgaaccggtc gtagaacgtg cgcttggatg tgcgggcgtg ccggacgatg tcggagacgg
163141 tggtggcgcg ataaccccgc tcaccgatcg aggcgaccag gccgtcgagc aaccgtagcc
163201 gaaacgagtc ggtctcgacg accaacgcgc cggcggcgac tgctgtcacc cgcgcctcct
163261 ctacctatcc cttgtcaggt ttggtaccaa agagtaccgt actggacaag ccacggtaca
163321 ccaccgtacc acgcccgatc cagggacgtt aggagcaaca ccgccatgag cgaagtcgtc
163381 accgccgcac cggcaccgcc cgtagtccga cttcccccgg cggtccgcgg gccgaagttg
163441 ttccagggat tggccttcgt ggtgtcacgg cgacggctgc tggggcggtt cgtgcgtcgc
163501 tacggcaagg ccttcaccgc caatatcctg atgtacggcc gggtcgtggt ggtcgccgac
163561 ccgcagctag ccaggcaggt cttcaccagc agtcctgagg agctgggcaa catccagccc
163621 aacctgagtc ggatgttcgg ttccggctcg gtgttcgcgc tggacggcga cgaccaccgg
163681 cggcggcgcc ggctactggc gccgcctttc cacggcaaga gcatgaagaa ctacgagacc
163741 atcatcgaag aggagaccct gcgcgagacc gccaattggc cgcaaggaca ggctttcgca
163801 acgctgccgt caatgatgca tatcacgctc aacgccatcc tgcgtgcgat cttcggggcc
163861 ggcggcagtg aactagacga gctgcgccgc ctcattccgc cgtgggtcac gctgggctcg
163921 cgcctggcgg cgctaccgaa acccaaacgc gactatggcc gccttagccc gtggggccgg
163981 ctggccgagt ggcggcgcca gtacgacact gtcatcgaca agctcatcga agccgagcgg
164041 gccgacccga acttcgccga tcggaccgac gtattggcgt tgatgctgcg cagcacttac
164101 gacgacggtt ccatcatgtc gcgcaaggac attggcgacg agctgctcac gctgctggcc
164161 gccgggcacg aaaccacggc ggcgacactg ggctgggcgt tcgagcggct cagccggcac
164221 cccgacgtgc tcgcggctct ggtcgaggag gtcgacaacg gcggtcacga gctgcgtcaa
164281 gcggcgatcc tggaggtaca gcgggccagg accgtcatcg attttgcggc tcgtcgcgtc
164341 aatccacccg tttaccagct cggcgagtgg gtgattcccc gcgggtattc gatcattatc
164401 aatatcgccc agatacatgg cgatcccgac gtcttcccgc agccggatcg cttcgacccg
164461 cagcgctaca tcggaagtaa gccatccccg tttgcgtgga tcccttttgg tggcgggacc
164521 cgccgctgtg tcggggccgc attcgccaac atggagatgg atgtggtgct gcgaacggtg
164581 ctgcgccact tcaccctcga gaccaccacg gccgcgggcg agcgcagcca cggtcgagga
164641 gttgcattca ccccgaagga tggcggtcgg gtggtgatgc gccgacgctg acggccagct
164701 cgggcccgcg ttcaggtccc gagttcgggt gaaaggctgg cccgcagtgc agattcggcg
164761 gtccgtcggg gtagcctcca gccgggccgg acgaagtggc acgtgtaccc gttggggtag
164821 cgctgcaggt agtcctggtg ctcgggttcg gcttcccaga aatccccggc cgggctgacc
164881 tcggtcacca ccttgccggg ccacaggccg gatgcctcga catcggcgat ggtgtccagc
164941 gcgatccgct tttgctgctc atcgaagtag aagatggccg accggtagct ggtcccccgg
165001 tcgttacctt gccggtcttt ggttgtcggg tcgtggatct ggaagaagaa ttccagcagg
165061 gtgcggtaat cggtgaccgt ggggtcgaag atgatttcga cggcttcggc gtgcgtgccg
165121 tggttacggt aggttgcgtt ggggatgttc ccgccgctgt agcccacccg cgtggagacc
165181 acaccgggct ggttgcggat cagatcctgc agcccccaaa agcagccgcc ggcgaggatc
165241 gctttctgat tgctcgtcat ttccggacct cccgatcagg ctacactccg gcgatggagt
165301 gtaacggcgc gaagaccgca ctgtgagcgc ttcggagttc tcccgtgctg aactcgccgc
165361 cgccttcgag aagttcgaga agaccgtggc ccgcgccgcc gcgacgcgcg actgggattg
165421 ctgggtgcag cactacaccc ccgacgtcga atacatcgag cacgcggcgg gcatcatgcg
165481 aggccgccag cgggtacgtg cctggattca agaaacgatg acgaccttcc cgggcagtca
165541 catggtggcc ttcccgtcgc tgtggtcggt gatcgacgag tccaccgggc gaattatctg
165601 cgaattggac aaccccatgc tcgaccccgg cgacggcagc gtgatcagcg cgacgaacat
165661 ttcgatcatc acctatgccg gcaatggcca gtggtgccgt caagaagaca tctacaaccc
165721 gttgcggttc ctgcgggcgg cgatgaagtg gtgtcgcaag gcgcaggagt tgggcaccct
165781 cgacgaggac gcggcgcgtt ggatgcgccg gcatggaggt ccttaaatga acgcacccaa
165841 gctggtcatt ggcgcgaacg gcttcctggg ttcgcacgtg actcgccagc tcgtcgccga
165901 ctgcgcgccg cagaaaggtg aggtacgcgc gatggtgcga cccgctgcca acacccggag
165961 catcgacgat ctaccgctca cccgattcca cggcgacgtc ttcgacaccg ccaccgtggc
166021 cgaggcgatg gccggctgcg acgacgtcta ctactgtgtg gtcgacaccc gcgcctggtt
166081 gcgcgatccc tccccgctgt ttcgcaccaa tgtggcaggc ctgcgcaacg tcctcgatgt
166141 ggccacagac gccagcctgc gcaggttcgt cttcaccagc agttatgcga cggtgggtcg
166201 tcggcgtgga cacgtggcga ccgaagaaga ccgggtggat acccgcaagg tgactcctta
166261 cgtgcggtcc cgggtggcgg ccgaggatct ggtgctgcaa tacgcgcacg acgcaggtct
166321 gcccgccgtc gcgatgtgtg tgtcgacaac ctacggcggc ggcgactggg gccgcacccc
166381 acacggcgcc ttcatcgcgg gcgcggtgtt cggcaggctg cctttcacga tgcgcggcat
166441 ccggctggag gcggtgggtg tcgacgatgc tgcgagggcg ctgatcttgg cggccgaacg
166501 cgggcgcaac ggcgaacggt acctcatctc cgaacgcatg atgccgttgc aagaagtggt
166561 gcggatcgcc gcggatgagg ccggtgtccc gccgccacga tggtcgatct cggtgccggt
166621 gctttacgcc ctgggtgcgt tgggcagttt gcgagcccga ctcacgggca aagataccga
166681 actcagcctg gcgtcggtgc gcatgatgcg ttccgaggcc gatgtcgacc acggcaaggc
166741 cgtccgcgag ttgggttggc agccacgtcc ggtggaggag tcgatccggg aggccgcccg
166801 gttctgggcg gcgatgcgca ccgtcgggaa ggaccccgcg gcctcgtgat ccgaaaaggc
166861 ctagggacgc tgccgggaat gttgatcgcc ggcacgtgtt gcacaggtca tgagcaaccg
166921 gattgtgtta gaacccagcg ccgatcaccc gatcaccatc gagccgacca accgacgggt
166981 gcaggtacgc gtcaatggcg aggtggtcgc ggacacggcc gcggcgctgt gcttgcagga
167041 agccagttac cctgcagtgc aatatattcc gttggccgac gtggtacagg ataggctgat
167101 ccgcaccgag accagcacct attgcccgtt caagggtgaa gccagctatt acagcgtgac
167161 taccgacgcc ggcgacatcg tcgacgacgt gatgtggacg tacgaaaacc cttatccggc
167221 ggtagcggcg atcgcggggc atgtcgcgtg ctatccggac aaagccgaaa tcagcatctt
167281 cccggggtag cgcaggctac cgggtatacc tcggccaacg actgggtgtc gctgtattcg
167341 cgcagcgaga tgatcatccc gtcacgggtc tcgaagatgc agacgaacgg gctgtcatat
167401 cgggtccggt cggcgctcac accgtcgcaa tgcccctcga ccactaccgt ttcaccctcg
167461 ttgacgcagc ggatgagttc gatgttgacc tcgaagacct gcttgcgccg ctcgactgct
167521 cgccgaaacg tcttcttgtc caattccgta cgggtgacga tgctccagta ggtgaagtcg
167581 ttgctgagca gcgcgaagcc ttcgtcgaga tctccgccct cgcagaggct ttgcaggaac
167641 atccaggcca gttcggcttg cgggtcgtcg aacggcgtca tcacatcgcc atcttgtctc
167701 gggagacagc gtgcggtcaa ttgacgtggt cgtcgaagcg gtggtcacct tcgcgggggc
167761 ggccggcttc gcgcacacct tggcgccgtt gcgtcgcggt cagcaggatc catgctttcg
167821 ggtccccggt gacggcacta tctggcggac cagcttgctg cccaccgggc cggtcaccgc
167881 gcggatcagc cgtgctgggc gcgacgccgc ccgttgcgtg gcgtggggca gcggtgccga
167941 ggagtttgtc gacatggcgc ccgccatgct gggcgccgcc gacgacgcca gcgatttcgt
168001 gccgctgcat ccggccgtgg ccgccgcgca ccgccggctg ccgaacttgc gcctgggccg
168061 caccggccag gtgctggaag ccttgatccc ggcggtcatc gagcagcggg tacccggcgc
168121 cgacgcgttt cggtcgtggc ggctgttggt gtccaagtac ggaacgcagg cccccggtcc
168181 ggcgccaccc ggcatgcggg tgccgccgtc ggccgaggtg tggcgtcaca tcccgtcctg
168241 ggagtttcat cgcgccaatg tcgacccggg gcgggctcgc gcggtggtgg gttgcgcgca
168301 gcgggcggcg tcgctggagc ggctggtgtc gctgcccgcg gctcgggcgg cggaggcgct
168361 gacatcgttg cctggagtcg gggtatggac cgcggccgag accacacaac gcgtgttcgg
168421 tgacgccgac gccgtgtcgg tcggcgacta ccacattccg aagatgatcg gctggacgct
168481 tgtgggccgg ccggtcgacg acgccggcat gctcgagctg ctggagccga tgcgcccgca
168541 tcgccaccgg gtggtccgct tgctcgaagc cagcggcttg gcgcgtgagc cgcgccgcgg
168601 gccccggctg ccggtacaga acatccgggc gctgtagggg agtttgacgg ggatcttgct
168661 cggtccggcg ccccgattcc cgccagatcg gctgccggcg ccgctaagcc gttgtcggcc
168721 gatcactgcc tccgcgttcg gcctcggcgg tctgccggtt cagtcgctgc gtctcgtaga
168781 tggtgacgtt ggtgcgagac aacaacagtg ccgcgatacc gacggcgatg atcgctccag
168841 gcaccaccga gaacgagccg gtcatctcag cgaccatgat catgacggcc agcggcgcgc
168901 gggagacact gccgaagcac gccatcattg cgaccacgac gaagatgccc ggctcgtggg
168961 gcaccccggg cagctcggtg agctcgccta gccgccagat cgccgctccg acgaaggcgc
169021 cgatcacgat tcccggcccg aatagcccgc ctgatccgcc ggtgccgatc gacagcgacg
169081 tcgcgaggat cttggcgatc ggcaagacga tgacgatcca caacgggatg ctcagcagcg
169141 tcccccgatc ggcggctagc tgcgcccagc catagccgct gctcaggatc tggggaatcg
169201 gcagacctaa cagcccgacc agcagtccgc cgatcgccgg tttgagcacc gggcccccgg
169261 gcagccggcg cgtaattgcc accgacgcgt gaaagactcg ggcatacaag tagcctacgg
169321 cggctgcgat cagcccgatc accacgaacc acagtagtgg ccacgccttt tcgaagcgat
169381 actcggcgtc gatgtagccg aacagcgggt cgaagcccaa gaaggcgccg agcacggcgt
169441 aggcggttcc cgaggcgatg aaacccggca gcaggttgcg gtagtcgaag tcgtcgcggt
169501 aggggatcga ggcgcccaac gccgctccgc ccagtggcgc agcgaagatg gcgccgatgc
169561 cggcgccgat acccagcgct accgcggtcc ggccgtcttc gttggacagg ttcagccggc
169621 gggtcagcag tgagcagaag ccggccgaga tctgcgcggt cgggccttcg cggccgcctg
169681 aaccgcccga gccgatggtc aaggcgctgg ccaccatctt caccagcacc gcccgacctc
169741 ggatggcgcg cggatcgccg tgcaccgact cgatcgcttc gtcggtgccg tgaccggtgg
169801 cctccggggc gagcttggcc acgatcaatg ccgacagcac cgccccgccc gtcgtcacca
169861 gcggaatcgc ccacggacgc gcgaaaccgg tggacccgcg gtggccgccc tccccaacgg
169921 gagtgggaat ctgatagtcc gcgaggtagc cgagcagaaa ctcgctggtg tatttcagcg
169981 cgaggtagaa gacgacggcg cccaggccgg caatgacacc gatcgtgatg cctagcagga
170041 accatttgcg caggtagccc gcgctcctga tcgatacgcc gaatcgtccg ccggcggcct
170101 cgttcccgat gtcttccgcc tccggcatgg tcgggaggtt agcagcatgc caagcgaaca
170161 ccgaccagtc gcccggcgcc atcccagagt tggccagcgc tatccgacga tcagcagcgc
170221 aaccatggcc caggtctgga cgtacgcgat caccgccgct gtgcggcgag gagatccgaa
170281 acggtgccgc actcttggac cccgacctct gtcatgacgc cgccgctcgt cgtggccgcg
170341 ttcaggccgg tcggccatta ccgactcgca acggacagag ccggtgggcc ctgctcgccc
170401 ccggcgaccg gagccaagct gacaagttcc gtagcatccc gcccaacggt aggtaccaag
170461 ccgcagtggt ggcacacttt agtgatgtca atgtcgctca cggccggtcg cggcccggga
170521 cgtcccccgg cggcgaaagc agatgagact cggaagcgta ttctgcacgc cgcccgtcaa
170581 gtgttcagcg aacgtggtta tgacggcgcg acttttcagg agatcgccgt ccgcgccgac
170641 ctgacccgac cggcgatcaa ccactacttc gccaacaagc gggtgctcta ccaagaggtg
170701 gtggagcaaa cccacgaact cgtcattgtg gccggcatcg aacgggcacg ccgcgagccg
170761 accttgatgg ggcggctggc ggtcgtcgtt gacttcgcga tggaggccga tgcccagtat
170821 cccgcctcga ccgcgttcct ggccaccacc gtgctcgaat cccagcggca tccagaattg
170881 agtcggaccg aaaacgatgc ggtgcgagca acccgagaat tcctggtttg ggctgtcaat
170941 gatgcgatcg aacgcggtga actagccgcc gacgtcgatg tctcttcgtt ggccgagacg
171001 ctgttggtcg tgttgtgtgg cgtgggcttc tatatcggtt ttgtcgggag ctatcagcgg
171061 atggcgacca tcaccgattc gttccagcag ctgttggccg gcacgctctg gcggcctccg
171121 acctgaccga gacctaaccg gcggccccga agcgtagtga tgtgccacac aaatcgtata
171181 ggttacctaa cttacttagg tagcatggca tgccgtgacc gaactcgacg acgtgtcctc
171241 gttaccatcc tcgcgacgga ccgctggcga tacctgggcg atcaccgaaa gcgttggcgc
171301 caccgcgttg ggggtcgcgg cggcacgtgc cgtggaaacg gccgcgacca atccgctgat
171361 ccgtgacgag ttcgccaagg tgttggtgtc gtcggcgggt accgcctggg cacggctggc
171421 cgacgccgat ttggcctggc tcgacggtga tcagctcggc cgacgcgtgc atcgggttgc
171481 ctgcgactac caggcggtgc gcacccactt cttcgacgag tacttcggtg ccgccgtcga
171541 cgcaggtgtc cggcaggtgg tgatcctcgc tgccggactg gacgctcggg cctaccgcct
171601 gaactggccg gcgggcactg tggtttacga gatcgaccag ccttcggtgt tggagtacaa
171661 ggcggggatt cttcaatcgc atggcgcggt tccaacggcg agacggcatg ccgtcgcggt
171721 ggacctgcgc gacgactggc cggccgcgct gatagctgcc ggattcgatg gcacccaacc
171781 gactgcctgg ctagccgagg gcttgctacc ctacctgccc ggcgacgccg cggaccggct
171841 attcgacatg gtcaccgcgc tcagcgcacc gggcagccag gtcgctgtcg aggctttcac
171901 catgaacaca aagggcaaca cgcagcgctg gaatcggatg cgcgagcgac tcggtttaga
171961 catcgatgtc caggcgttga cctaccacga gcccgaccgg tcggatgccg cgcaatggct
172021 ggccacgcat ggctggcagg tgcacagcgt gagcaatcgc gaggagatgg cccgactggg
172081 ccgggcgatc ccgcaagacc tggtcgacga gaccgtccgc accacgttgc tgcgagggcg
172141 tctggtcaca cccgctcaac cggcgtgaca ccggcatcac gagaaccaga gggagcacag
172201 gatgagcgcc atgcgcaccc atgacgacac ctgggatatc aagaccagcg tcggcgccac
172261 cgcagtgatg gtggctgctg cccgggccgt cgaaaccgac cggcccgacc cgctgatccg
172321 cgatccctac gccagactgc tcgtcaccaa cgccggggcc ggcgccattt gggaagccat
172381 gctcgaccca acactggtag ccaaggcggc tgccatcgat gccgaaaccg cggccatcgt
172441 cgcctatctg cgcagctacc aagcggtgcg gaccaacttc ttcgatacct acttcgccag
172501 cgctgtcgcc gccggaatcc ggcaggtagt gattctggcg tccggactgg attcccgcgc
172561 ctatcgcctg gactggcccg ccggaaccat cgtgtatgag atcgatcaac ccaaggtgct
172621 ttcctacaag tccacgacgc tggcggaaaa cggggtaacg ccgtcggctg gtcgccgtga
172681 ggtgcccgcc gacctgcgcc aggactggcc cgccgcgctg cgtgatgccg ggtttgaccc
172741 gacggcacgc acggcgtggt tggccgaggg gctgttgatg tacctaccgg ccgaggccca
172801 ggaccggctg ttcacccagg tcggcgccgt gagcgtggcg ggcagccgga tcgcggccga
172861 gactgcgccg gtgcacggcg aagagcggcg agcagaaatg cgggcacggt tcaagaaagt
172921 ggccgatgtg ctcggtatcg agcagaccat cgacgtgcag gaactggtct accacgacca
172981 ggatcgggcg tccgttgccg actggctcac cgatcacggt tggcgggccc gatcccaacg
173041 tgcgcccgac gagatgcgcc gcgtgggtcg ctgggttgag ggggtgccga tggcggacga
173101 cccgactgcg ttcgccgagt ttgtcaccgc agagcggttg tagcgagcgc atccgactga
173161 ccttatatat ccggatatat ggctggatct tttctattgc tggttcaacc gggtgactag
173221 gatcgcggtt atcaccgatg agtgaccgcg tcaaggcggt cgcgccgccg gacggaagga
173281 cgatgatgac caccgaatcg gttgcccgga agacccagaa atctgagacc gaggctccgc
173341 gcgaaccggc gcccgtttcg gatgaaaagc aaaccgatgt cgctaaaacg gtggctcggc
173401 tgcgaaagac ctttgccagc gggcgtaccc gcagcgtcga gtggcgcaag cagcagttgc
173461 gcgcgctaca gaagttgatg gacgagaacg aggacgcgat cgccgcggca ctcgccgagg
173521 atctggatcg caatccgttc gaggcatacc tcgctgacat cgcgacgacc tccgccgaag
173581 cgaaatacgc ggccaagcgg gtgcgcaggt ggatgcggcg ccgctacctg ctgctcgagg
173641 tgccgcagct gcccggccgc ggctgggtgg agtacgagcc atatggcacc gtgctaatca
173701 tcggtgcctg gaactacccg ttctacctga ccctgggtcc ggcggtcgga gccattgccg
173761 ctggaaacgc cgtcgtgctc aaaccgtcgg aaatcgccgc tgcatcggcg cacttgatga
173821 ccgaattggt gtatcgctat ctcgacaccg aagcgatcgc ggtcgtgcag ggcgatggtg
173881 cggtgagtca ggagctgatc gctcagggtt tcgaccgcgt gatgttcacc ggtggcaccg
173941 agatcggccg caaggtctac gaaggcgccg cgccgcacct gaccccggtc accctcgagc
174001 tcggcggcaa gagcccggtg atcgtcgcgg ccgatgccga tgtagatgtc gcggccaagc
174061 ggatcgcctg gatcaaactg ctcaacgccg ggcagacatg cgttgcaccc gactatgtgc
174121 tggcggatgc caccgtccgc gacgagctgg tcagcaagat caccgcggcc ctcaccaagt
174181 tccgctccgg tgcgccgcag ggcatgcgca tcgtcaacca gcgtcaattc gaccggctga
174241 gtggatacct cgccgcagcg aaaaccgacg ctgcagccga cggcggcggg gtcgtcgtgg
174301 gcggcgactg tgacgcatcg aacctgcgca tccaacccac cgtggtcgtc gatcccgacc
174361 cggacgggcc gttgatgagc aacgagatct tcggaccgat cctgccggtg gtcaccgtca
174421 aatctctgga cgacgcgatt cgcttcgtga actcgcggcc caagccgcta tcggcgtacc
174481 tgttcactaa gtcgcgtgcg gttcgcgagc gggtgatcag ggaggtgccg gcgggcggaa
174541 tgatggttaa ccatttggct tttcaggtgt cgacggccaa actgccgttc ggtggtgtcg
174601 gcgcatcggg catgggtgcc taccacggcc gttggggttt cgaggagttc agccaccgta
174661 agtcggtgtt gaccaaacca acccgacccg acctgtccag ctttatctac ccgccgtaca
174721 ccgagcgcgc catcaaggtg gctcgccggc tgttctgacc tgggcgcggg ttgtcgcccc
174781 gttgacaccc gactcgttat aaccccgaat tgtgattgcg gagaggagcc tgatgcccgg
174841 agtgcaagat cgcgtcatcg tcgttactgg agccggcggt ggcttgggcc gcgaatacgc
174901 ccttacgctc gccggggagg gcgccagcgt cgtggtcaac gacctcggtg gcgcccgcga
174961 cggcacgggc gccggttcgg cgatggccga tgaggtcgtc gccgagattc gcgacaaggg
175021 gggccgggcg gtcgccaact acgacagcgt cgccaccgag gacggcgcag cgaacatcat
175081 caagaccgcg cttgacgaat tcggcgccgt gcacggtgtg gtgagcaacg ccgggatctt
175141 gcgcgacggc accttccaca agatgtcgtt cgagaattgg gacgccgtgc ttaaggtgca
175201 cctttatggc ggataccacg tgctacgcgc ggcctggccg catttccgtg agcagagtta
175261 cggccgggtc gtggtggcga cctccaccag cgggctgttc ggcaacttcg gccagaccaa
175321 ctatggggcg gccaagcttg gtctggtcgg cctgatcaat acgctggcgc tggagggagc
175381 caagtacaac atccacgcca atgctcttgc cccgatcgcg gcgaccagga tgacccagga
175441 catcctgccg cccgaagtac tggaaaagct cacacccgag ttcgtcgcac cggtggtggc
175501 ctacctgtgc accgaggagt gtgccgacaa cgcatcggtg tacgtcgtcg gtggtggcaa
175561 ggtgcagcga gttgcgctgt ttggcaacga cggcgccaac ttcgacaaac cgccgtcggt
175621 acaagatgtt gcggcgcggt gggccgagat caccgatctg tccggtgcga aaattgctgg
175681 attcaagttg tagaagtaaa tgaaggcttg tgtcgtaaaa gaactttccg gcccgtccgg
175741 catggtgtac accgacatcg acgaggtatc cggtgacggc ggaaaggttg ttatcgacgt
175801 acgggccgcc ggcgtctgct ttccggacct gctgctgacc aagggcgagt atcaactgaa
175861 gctaacgccg ccgttcgtgc ccggcatgga aacggcgggt gtggtgcgtt cggcgccgtc
175921 ggatgcgggt tttcatgtgg gcgaacgtgt ttcagcattc ggagtgctcg gcggctacgc
175981 cgaacaaata gccgtaccgg tggccaatgt ggttcgcagc cccgtcgagc tcgatgacgc
176041 cggggcggtg tcgctgttgg tgaactacaa caccatgtac ttcgccctgg ctcggcgtgc
176101 cgcgctgcga ccgggagaca ccgtgctggt gctcggcgcc gccggcggag tgggcacggc
176161 cgccgtccag atcgcgaagg cgatgcaggc tggcaaggtg atagccatgg tgcaccgcga
176221 aggtgcgatc gactatgtcg cttcgctcgg tgccgacgtg gtgcttccgc tgaccgaggg
176281 ctgggctcag caggtgcgtg accacaccta cggtcagggg gtggacatcg tcgtcgatcc
176341 catcggcgga ccgacattcg acgacgcgct cggcgtgctg gcgatcgacg gcaagttatt
176401 gttgatcggc tttgccgcgg gtgctgtacc gaccctcaag gtcaaccggc tgctggtgcg
176461 caatatcagc gtggtgggcg tcgggtgggg cgagtatctc aacgcggttc ccggttcggc
176521 cgccttgttc gcctgggggc taaaccagct ggtctttctg gggctcagac cgcctccgcc
176581 gcaacgctat ccgttgtcgg aagcacaggc cgcgttgcag agtctggacg acggcggtgt
176641 gctcggcaag gttgtgctcg agccctaagc gcatgctcgc gattcggcga tacggtgatg
176701 ctgtgacgga tcggcgggcc aacacgagga attcgcaccc gctgccggcg tgaccaacgc
176761 cacgctggca gcaatcgggt atccgatcgc gttggccagc aagctgttgg cgatatcggc
176821 cgtcgaaagc acaaccgcgt agccgtccgc aaccacagtg gaaatggtgc tggcgatctt
176881 ggtgtgcgcg agcgcttcga tgccagggtc agggagcccg gtgggcgccc ggtcgtcggg
176941 caacgtcagc atcgacgagc cgccggtctg tgacaagttc gccaacaacg gattgggcag
177001 ccacgccggt acctggcgcg gatgtggtgc acgaacgcgt tgacatattg ggggctcttc
177061 gcggatgagg gtgtagggcg ggtcggcgcg tcgttgccgg gtaggggtcg cggtctttcg
177121 atgatgggcg gttccacgct gccgaaaagg aagacctcgg cgtgtctgcc cgaggcacta
177181 ggtcgcaagg gtaaccgagg gtgcacgttg acggggtgag gccaagcggg cgccgagcgt
177241 gaactgaggg cgagatttcg gccgattctc cgccctcagt tcacgctggg cgacggcgcc
177301 aacgggctgc ccctggccgg tcgcaccaag acgccgcata cgtaccaaac ttcccatact
177361 cacccatcgc ggtgaacccc aaacccagtg ccggccacca ttggccttcc cgatggattg
177421 gtgccagcag caaccggcat catcgaaaac cggctcttca tgatcgaggg ccggcagcgg
177481 ctcgagcagc ggcaggccgg ggtgatcacg tagtagtgct gaatgacccg agcatcgggc
177541 gatcagatgc tgaagctttg cagttgctga gtaatgtcgg ccaacgtcac cacaatcgcg
177601 atgaattcaa tcatgccgcc cagggcggcc aacccaatgg tggccgcgag cggcagctcg
177661 atcgcagcgc ggaggttgcc ggccgccagt tgattcacga acagggtgag gtcataggcg
177721 ggcaggatag tgacgaaggc aagacctaga tctgccgtcg gaagaagaat cgagtagccg
177781 gtcgacacaa cggaagcgaa agtgtccgcg atgttgatga gcgtcgccgg ttgtggcggc
177841 ggtggcggcg gtagcagcgt cggcacatac ggcgggaacg cgggcatcgg agtttggggc
177901 agggtgttca gggcggctgg caactcgacc atgaagtcgt tgacgccctg ttgcgttccg
177961 gcaaccaggg catcggcgac aacgctcgcc gggacatccg ggaagagccc gaatggggta
178021 ggcacgttcg ccgggctcgt cgaatagccg aacctcgggt cgccgtaacc cagattgacg
178081 attacttcca agttcggttc gaccagcgcc gccagcggtg ggccaatgac cgggattgcc
178141 cgcaacgggg ccagcagcgg cagatgctcg gtttcaatga tgtagtacgt gttcgacgtc
178201 gtgccctgtg tcggcaactg cgtggccgac gctatctgtg ccggtgtgag gtccgcatac
178261 gtggtgtgca ccgtgagtat cccgaatact gcgttgatat cggacaggac attgagtgga
178321 taccgcggga agtcggcgaa accgtcgtac tcgagggtgt aggtcgtcgt cggataggga
178381 ttgtccgggg tcgccccgta gaacggtagg ccgagggtgg tgacattcag accgggtatg
178441 cgcgcaagta tcccgccatt gggattcatc tcgttgccga tcaagatgaa attgagctgg
178501 ctggggctgg gagcgttggg acccagcgag atgaggtgct gcatttccag ggacgcgatg
178561 acggcgctct gcgaatagcc gaacacggtg acgtggtttc cggcgttgat ttgctcccaa
178621 atcgcgccgt cgagaatctg taggcccaac tgcaccgagg tttggaaggg cagggatttg
178681 acgccggtga tcggatatag ctcttcgggc gtcaccagcg ctttgacgac cggattcgag
178741 acgacggggt cgatgaacaa ggtcgtgatg gcgttgacat aactcggcgt gggtatcggt
178801 gacccggtgc cgcccatgat gatcgccgta ttttggttga acattggcgg tagcaccggg
178861 ggtgaggttg gcttaaagag tccggccgtc gcctcctgca ccagcgcgct cgtgttggtg
178921 gcctcggcat tgacaaatgc gtttgcggcc gccgccaacc tctgggtgaa ttcgttgtga
178981 aacgccgcaa cctgtgcgct gatcgcctgg aactgctggc cgtacgcgcc gaacagcgtg
179041 gcaagggccg tggacacttc gtccgcggca gccgccgcca ggccggttgt cggggccgcg
179101 acggccgccg tagcctggtt gatcgccgag ccgatcccgg ccaaatcggt agccgccgct
179161 gccaataccg acggctgcgc gaatacgtac gacaaacccc atccctcctt gtcgacgggg
179221 cccataaccc acccgtcgag ccgatacgtt gagcgtaaag cgactccgcg gttgtgtctg
179281 gcctttggag tgaacccaaa tggggccatg ctgcctcgtc attggcgagg tcggtaaacg
179341 gtagtcggtg gacgtcgatg ccgtcgggaa tccgttaggt gacgaggccc tcgatgtttc
179401 gaacggtgtc cgaggccgcc gcgaggaggg tgagcaattc cacgccgccc gctatcgatc
179461 gtgcctaaac ctacggtggc cgccagggga tagccgatcg cgttgatcag attgcccgca
179521 gcgagttgcc tgacgaacag ttgggtggtg tacagcggca gggtggtgac cagggcgagg
179581 gcgatgtcca cggtgggcag caggacggcg tagttggttg agatgatcct ggcgagcgtg
179641 ttcaccacct cggccggcgt cggtgcggcg gccaccgcgg ccaccagatc ggcgggttgc
179701 ggcagctgga tctgcgggag cgtgagcggt tgcgcggaca gcgcctgcag gtcggccgtg
179761 aagtcaagga tgccttcttg tgttccggcg gccagggcat cggcgatgac ctgaggcggc
179821 acgttcggcc acagcccgaa cggcgttcgc acatcggcgt agctcgtcga gtagccgtag
179881 ttcgggtcgc cgtagcccag gttgacgatc accttcaggt tcggctggat caggtcggcc
179941 agcggatctc cgatgaccgg caccgcccgc agcggttgca gcagcggccg attctcggtg
180001 cggatgatgt agtagtcggt gacccccgta tagcccggcg acgtcggtaa tttagtagcg
180061 ccctcgacct gcgcgggcgt gaggtccaaa tacttggtgt gtacgaatgt gatgcctgca
180121 accgcgttga ggtcggaaat gaagttgagc gggtatcgcg agaagtcggc gaacccgtcg
180181 tactcgagcg tgtagatggc cgtcggatag atcgtgtccg agggcgttgc gccatagaac
180241 gtcaggtcca gagtcggaag cgtcagatcc gggaaccgcg cgagcatacc gccattgggg
180301 ttcatttcat tgccgacaag cacgaaattg aggtcgctcg ccgaaggtgc ggccccgccc
180361 atcgccgtga acctctgcat ctccagcgac gcgattatgg cgctttgcga ccagccgaaa
180421 acggtgaccg cgtttccggt ggtcgcgagc tctaccatga tcgcgtcgtg caagatggtc
180481 aagccctctt ccactgacgt gttgaggacc aaacttctga caccggtgag tgggtacaac
180541 tcttcgggtg tgaagacggc ttgtagcgcc cgccgaacgg acctacagcg tattggcggc
180601 gtcaacatag acggcggtgg tagtggaatt ccggtgggcc caaagaacaa ggtggtcaag
180661 ttcgccggga atggcggaat catcgcggcc gccgcggggg ttggtgcggc ggcgggcaca
180721 gccagctgat tttgccgggt gctggcgatg gcggcctcgg catctgcgta gctgttcgcc
180781 gcggcggcca acgtctggtg gaacctaact gtgaaacgcc tcgacttgag cgagcacggc
180841 ctggtattcc tggccgtatg cgccgaacgg tttcgcgatg gcggccgaca cctcatcgcc
180901 ggccgccgcg gccagtgcac acgtcgggcc tgccgcggcc gcgccggccg tactcacggc
180961 cgaaccgatt cctgccacct cggcggcggc cgccgctacg atccgcggct cagcgatcag
181021 atacgacatc gtctcactcc cctagcacca ggtgtcggcc aaccgggtca acccggggtt
181081 ttggtcagcc cagagcggtc ccgctgccct ggtggtcgct tacgcgaatc ggattcgcgc
181141 gaaagcgttt cccctcatcc gagcagcacc ccgcgcatcc ggttgactgt ggcctggctg
181201 ataccggcgt cgcgcaggta gccgcccagc gatccgtagg tctcgtcaat ggtctggcgt
181261 gcggcggcca ggtactccgc gcggacaccc aggaccccgt cggacagccg ggccttggtg
181321 aacgtcacca cctcgggtgc cagttcggtg tcgaaacgct gctggatcat ctcggagatc
181381 cgggcccgca gttgtggcac ggagtcgttg ctgcgcaggt agtcggcgac gatgacgtcg
181441 cggtccaggc cgaccgcttc aagcaccagc gcgaccacga agccggtgcg atccttaccc
181501 gcgaagcagt gggtgagcac cgggcgtccg gcggcaagca gtgtgacgac acgatgtagc
181561 gcgcgctgtg ctccattgcg cgttgggaat tggcgatact cgtcggtcat gtagcgggtg
181621 gccgcgtcat ttatcgactg gctggattcg ccggactcgc cgttggaccc gtcattggtt
181681 agcagcctct tgaatgcggt ttcgtgcggc gctgagtcgt cggcgtcatc atcggcgagg
181741 tcggggaacg gcagcaggtg gacgtcgatg ccgtccggaa cccgtcctgg accgcggcgg
181801 gcaacctccc gggacgaccg caggtcggca acgtcggtga tccccagccg gcgcagcgtt
181861 gcccggccgg cgtcgtcgag gcggctcagc tcgctggacc ggaacagccg ccccggccgc
181921 aatgcggttg cggtgtcggc gacgtcacga aagttccacg cgcccggcag ttcacggaca
181981 gccatctcag gtgaccgccg cagcgaaggt ggacttctcc ctcgacagct cggcgcgggc
182041 gatggagcgc aggtgcacct cgtcgggacc gtcgaagatg cgcatggcgc ggtgccagcc
182101 gtacaaccgg gccagcgggg tgtcgtcgct gacgccggcg gccccgtgga cctggattgc
182161 gcggtcgatg acatcgcagg ccacccgcgg ggccaccgcc ttgatcatgg cgaccaggtg
182221 gcgcgcctct ttgttgccat gttggtcgat tgtccacgcc gccttttcgc acagcagcct
182281 tgcctggtcg atttcgttgc gggactgagc aatcgcctgt tgcacgacgc cctgttcggc
182341 tagcggacgg ccgaacgcca cccggttgcg gacgcgattc accatgagtg ccaaggcgcg
182401 ttcggccgcg cccagcgcac gcatgcagtg gtggatacgg cccggcccca gccgggcctg
182461 ggctatggcg aatccgctgc cctcttcgcc gagcaggttg gtggccggga cccggacgtt
182521 gtggtagtcg atctcgcagt ggccgtgccg gtcctgccag ccgaacaccg gtgtggagcg
182581 aacgatcgtc acgccggggg tgtcgatcgg gacgaggacc atcgactgct gttggtgggc
182641 ggctgcgtcc gggttggtgc ggcccatcac gatgaggatc ttgcaccgcg ggtccgccgc
182701 tcccgacgtc caccacttac ggccgttgat gacgtagtcg gcaccgtccc gggagatggt
182761 ggtttcgatg ttgcgggcgt cgctgctggc caccgccggc tcggtcatcg agaaggcgct
182821 gcggatcttg ccgtcgagca gcggccgcag ccattgcgcc cgttgctgct cggtgccgaa
182881 catgtgcagg atctccatgt tgccggtgtc cggtgcggcg cagttgagtg cctcgggcgc
182941 gatttccatg ctccatccgg tcatttcggc cagcggcgcg tactccaggt tggtcaatcc
183001 cgactcggcc gacaggaata ggttccacag gccgcggtct ttggccttgg ttttcagttc
183061 ctcgatgatc ggcggcgcgg tgtggtcggc cggtccggcc gcgcggcgat agtcgtcgta
183121 atcggcctca gcgccgaaga cgtgctcggt catgaagtcg gacaaccgcg tgcggtagtc
183181 gatggccttg gccgacatcg cgaagtccat tccgccacga tatctaccgg cgctagcaga
183241 cgcataagtc cctcgacacg ccgacgagaa gggggttttg cgtctgctcg ccgtcgtttc
183301 gtgccaccgt tcaactgacc cgcaagtggc agcgcgagct cgactattcg ctacgcaaga
183361 gtttgtggag cttccacgac aaccgcattg cgatgcggtt ccagtacgaa tcccgtgacc
183421 gcaacggcca gtggtatcgc agctacggca ccgaactgtg gcgaagccag catcaacgac
183481 gtgccgatcg ccgaatccga gcgtcgctac ctcggtgcgc gctcggcatc cgagtatggc
183541 caggaaatac cgctctggta gcccggtagg gtgtctgagc aaatctatcg gcgttcagta
183601 aggaaagtgg atgtacgcgc catgacagat ccgcagacgc agagcaccag ggtcggggtg
183661 gttgccgagt cggggcccga cgaacgacgg gtcgcgctgg ttcccaaggc ggtcgcgtcg
183721 ctggtgaacc gtggtgtggc ggtcgtggtc gaggccggtg cgggcgagcg cgcgctgctt
183781 cccgatgagc tctacaccgc tgtcggtgcc agcatcgggg atgcttgggc cgccgacgtc
183841 gttgtcaagg tcgcgccgcc gacggcggcg gaggtcggcc ggttgcgcgg tgggcagaca
183901 ctgatcggct ttctagcgcc ccgtaatgct gacaactcga tcggcgcgct gacccaggcc
183961 ggggtgcagg cgttcgcgct cgaggccatc ccgcgcatct cgcgggcgca ggtgatggac
184021 gcgctgtcgt cgcaagccaa cgtgtctggg tataaggctg tgctgctcgc ggcctcggaa
184081 tcgacccggt tctttccgat gctgacgacg gcggccggaa cggtgaagcc ggccacggtg
184141 ctggtgctcg gcgtcggcgt ggccggcctg caggcgctgg cgacggccaa acggctaggc
184201 gcgcgcacca cgggctacga tgtgcgtccc gaggtggccg accaggtccg atcggtgggc
184261 gctcaatggc ttgatttggg catctcagcg tccggtgagg gcggttacgc ccgcgaactg
184321 accgacgacg agcgcgccca gcagcaaaag gcattggaag aagcgatcag tggcttcgac
184381 gtggtgatca ccaccgcgct ggtgccgggc cgcccggcgc caacgttggt gaccgccgct
184441 gcagtggaag cgatgaagcc tggcagcgtg gtggtggatc tcgccggcga gacgggcggc
184501 aactgcgaat tgaccgagcc cggccggaca gtcgtcaagc acgacgtcac cattgccgca
184561 ccgctgaacc tgccggccac gatgcccgag cacgccagcg agctctacag caagaacatc
184621 accgcgctac tcgacttgtt gatcaaagac ggcaggctgg ccccggactt cgacgacgag
184681 gtgattgccc agtcgtgtgt cacccgcggg aaggactcct agatgtacaa cgaattgttg
184741 gagaacctgg cgatcctggt gctgtccgga ttcgtcgggt tcgcggtgat ctcgaaagtg
184801 cccaacacgt tgcacacccc gctgatgtca ggaaccaacg ccatccacgg cattgtcgtt
184861 ctcggcgcgc tggtggtttt cggcgaaatt gagcacccat cgctcgtgtt gcaggtcatc
184921 ctgttcgtcg cggtggtgtt cggcacgctg aacgtcatcg gcggattcat cgtcaccgac
184981 cgaatgctcg gcatgttcaa ggccaagaag cccgccgtgc cagccaagcc cgaccgcgac
185041 gaggcgctcc gatgaacctg cactacctgg tcgagattct ctacatcatc tccttttcac
185101 tcttcatcta cgggttgatg gggctcaccg gccccaagac cgcggtgcgc gggaacctga
185161 tcgccgcggc cggcatgacc atcgccgtgg cggccacgtt ggtcatgatc cgacacacca
185221 gccaatggcc gctgatcatc gccggtctgg tggtgggtgt tgtgctcggt gtgccgccgg
185281 cgcgactgac caagatgacc gccatgccgc agctggtggc attcttcaac ggcgtgggcg
185341 gaggaacggt cgcactcatc gcgctgtcgg agttcatcga taccaccggc ttttccgcat
185401 tccagcacgg cgagtcgccg accgtgcaca tcgtggtggc ctcattgttc gccgcgatca
185461 tcgggtcgat ctcgttctgg gggtctatcg tcgcgttcgg caagttgcag gagatcatct
185521 ccgggcggcc gatcggactc ggcaaggcgc agcagccgat caacctgttg ctgctggccg
185581 tggccgtggc cgccgccgtg gtgatcggac tgcacgcgca tcccgggagc ggtggggtcg
185641 cattgtggtg gatgatcggc ctgttggtcg ccgccggcgt gctgggtctg atggtggtgt
185701 tgccgatcgg tggcgccgac atgccggtgg tcatctcgat gctcaacgcc atgaccggcc
185761 tgtcggccgc ggcggcgggt ctggcgttga acaacaccgc gatgatcgtg gccggcatga
185821 tcgtcggcgc gtccggctcg atcctgacca acctgatggc taaggcgatg aaccgctcca
185881 ttccggcgat cgtcgcgggc ggtttcggcg gcggcggtgt ggcgcccagt ggcggcggcg
185941 acgacaaaca cgtcaaggcc acttcggccg ccgatgccgc gatccagatg gcatacgcca
186001 atcaggtgat cgtggtgccc ggctacgggt tggccgtcgc gcaggcgcag catgcggtga
186061 aggacctggc aaccttgctg gaggacaggg gtgtgccggt caagtacgcg attcacccgg
186121 tcgccggccg gatgcccggg catatgaacg tgctgctggc cgaggccgaa gtcgactacg
186181 acgcgatgaa ggacatggac gacatcaacg acgagttcgc ccgcaccgac gtcaccatcg
186241 tgatcggcgc caacgacgtc accaacccgg cggcccgcaa cgagacgtcc agcccgatct
186301 acggcatgcc gatcctcaac gtggacaagt cgaggtcggt gatcgtgctc aaacggtcga
186361 tgaattccgg gttcgccggc atcgacaacc cgctgttcta cgccgacggc accactatgt
186421 tgttcggtga tgcgaagaaa tcggtgaccg aagtctccga ggaactcaag gcgttgtagc
186481 gcgcgagcgc tggctcagac gggcggatac gccggcggcg ggtatccgtc gccggtttcg
186541 accccgcgta gaccccaggt gaggtaccgg aagaagaact cgatttcgtc gctcacgtcg
186601 tagtcaggac tcggatccat cacttcaccc tctcgactcg cgacttggtt cgcaacggag
186661 tttagtcaca tccgcgccgg tgcgacaggt tgtcgccgcc ttgcctaaac tgaacaacca
186721 gttgattgat acagcttcgg ccggggccca tgggctccac cggcagcgac gatagcgagt
186781 agcgatgcca tccgacacca gccccaacgg gctaagccgc cgtgaggagt tgctggctgt
186841 tgccaccaaa ctattcgcgg cgcgcggtta tcacggcacc cggatggacg acgtcgccga
186901 tgtgatcggg ctcaacaaag caacggtcta tcactactac gccagcaagt cgctgatcct
186961 gttcgacatt taccgtcagg cggccgaggg caccctggcc gccgtgcacg acgatccgtc
187021 ctggacggcc cgtgaagcgc tgtaccagta cacggtccgg ctgctcactg cgatcgcgag
187081 caaccccgag cgggccgccg tgtacttcca ggagcagccc tacatcaccg agtggttcac
187141 cagcgagcag gtcgccgagg tccgcgagaa ggagcagcaa gtctacgagc acgtacacgg
187201 cctgatcgac cgcgggattg ccagcggcga gttctatgag tgcgactcgc atgtggtggc
187261 gctggggtac atcgggatga cgctgggcag ctaccgctgg ctgcggccga gcgggcgccg
187321 aacggccaag gagatcgcgg cggagttcag cacggcactg ctgcgcgggc tgatccgcga
187381 cgaatcgatc cgcaaccagt ctccgcttgg aactcggaag gaaacgtgaa cctcacgcga
187441 tcggtggaat caatctcgct acggacccga gggcgccact gagcaccgac aactccgtca
187501 cactggattg accgaagttg aacatcaggc ccggattcgc cgacggaaga tacggatacg
187561 tattgggtag cgcggactgc ggtaacaatc cgatgcttac tagggcggct tgggggcctt
187621 gcacggtccc ggtcgccagg gccgaggcca cggcgatcgg gttgattggc gcgaacaggc
187681 tggccggggt gggtacgtcg gcgtagccgt agccatagcc caagtcgact agcacccgta
187741 ggtcgggctg aatcagctcg gctattgggg tccctacgaa ggggatggcg cgaatcggct
187801 gcaacagcgg caggtcctgg gtcagaaaca tgtagtaatg ggtgttgccg gtgtagcccg
187861 gagacgtggg caacggcacg gcattggcaa cctcggccgc ggtgaagggg tacgcgttgt
187921 gcacccatct gatgcccatg aaggcgttga ggtccgacaa gatattgagc gggtactgcg
187981 ggttgtgggc gtagccgtcg tattggccgg tgtacatgta ggtctggtag ggggaatccg
188041 gtggagtcgc accgttgaac gacatatcca agaacgggag gtaaaggccc acgtaacgct
188101 cgaggacgcc gccgttgggg ttattgatat taccgatcaa cgtgaaagcc agccggcttg
188161 gatctggggc ttggcccggt ggtaacgcca taagagcgcg tatttcattg gtcgctaccg
188221 cggcgctttg cgagtagccg aaaacgacga cgtcatgccc attttgtagt tccgcgttga
188281 tgccgttgtt cagcagcgtg acaccctggg cgatggattg gtccagtgac aggttcccga
188341 taaacggcca ccactgctcg ggcgtgtact gggcgaccgg gttgttgggc ccgaaaatgg
188401 gccgaatgta tgcgctgtca atgatcgcca agacgcggtc actaaggatc ggttccccgg
188461 tgccgcccat catcaacgcg gttagcgggt tgcctgacag catcccgaca gaaccgaggg
188521 cgccgctgga cccggcggtg cccgacatag cagcggtgtt gctggcttca gcctgggcat
188581 aggcggcccc ggcggcagcc agcgcccggg tgaactcgcc atggaacgcc gcagcctgct
188641 ttaggacctc ttgacattcg cgcgcgtatt cgctgaacag cgctgcagcg gccgacgaca
188701 cctcatcggc ggccgcggcc agcagtccgg tcgttggacc cgcagcggac gcgctggccg
188761 ctcgtatcgc cgaaccgatc ccgtccacgt ccgcggccgt cgttgccaac atctccgggg
188821 ccgcgatgac gtaggacatc tggtctcctg ttcgacgctg gggcccttag agcctagagc
188881 gcgcccgccg ggaagcccgg cgttttcggc caatcgttat cgcggccgcg tcaggtgaag
188941 accggtggcg ggatcaggtg caggatgttg ccgagaccgc cactcatcag ggatagcagt
189001 gtcacctgtg gctggccgaa gtagaaattc aggcccgggt ttatcgacgg gacccacgga
189061 tagctgtccg ggaaccactc cggcccaatc aatccggctt ccaccccaat ctccacgatg
189121 gcgccatagg gcgcctgcag gctccctttg atcaggtaat acgtgacagc gaacgggttg
189181 gggatcgaga acagcccggc cggagtgggg atatccgcgt aattgccgcc cggcccgtag
189241 tcggcgtagc ccaagtcgac gagcacccgc agctgcggct ggaacaggtc ggcgatcggg
189301 ggaccggcgt aggggatgtc acggatcggc tggagcagtg gcagatcctg agtcaggaac
189361 atgtagtact gggtgttgcc ggtatagccc ggggaggtcg gcaacggcac cgcgttatcc
189421 acctgggtgg ccatgagttc cgggtacgtg ttgtgcacgt agaagtagcc catgaaggcg
189481 ttgatgtccg acaggatgcg cagcgggaat tgcggcgcgt gggcgatgcc gtcgtactgg
189541 gccgtgtaaa tgtgtgtcgg gtagggacta ttcgccgggg ttgcgccatt gaacggcacg
189601 tccaggaacg ggatgtagaa gccggggaag cgcgccagca gcccgccgac gggattgttg
189661 ccactaccaa tcatgacgaa ggagatatcg tccggattcg gcgaacccat cgccatcagc
189721 gaattgatgt agttgttgat gatcgtggcg ctctgcgagt agccgaacgc aacgaccttg
189781 ttgtcgaggg ccagttggtt gttgacggcg gtattcagca gcgccacgcc ttcggtgacg
189841 gactggttga acgtcagatt gccgaggtcg ggggtaaccg gccagaactg ctcgggcgtg
189901 aacaggcctt gcgagacagc acccgggaag agggtctgga tgaaagcctt gttgatgtct
189961 gtcacgtact cggggtcggg tagcgggtta ttggtgccgc ccataatcaa cgccgttatc
190021 ggactctccg cagccagctg cgcgatcgcc ggcagcccgc cggccccgct ggatccgttg
190081 gggctcaacg gcgcacggcc caacagcgtc cggatcggtg cgttgatagt gtccagcgcg
190141 tgcgataccc gggccgcatt ggccgcttcg gcgtgtgcgt aggcgttgcc ggcggcctcc
190201 aacgtccggg tgaactcgct gtggaacgcc gcggcctgct tgacgaccgc ctgatactcc
190261 cgcccgtatg cgctgaacag ggccgccgtt gccgccgaaa cctcatcgcc ggccgcggcc
190321 agcaggttac atgtcgggcc tgccgcagcc gcgttggcgg cccgcagcgt ggaagcgatc
190381 tcatccacat gggcagctgc cgtcgccagc atgtcagggg ctgtgaccag gtgcgacatc
190441 tccccgtcct tcccaacgga ccggcgcccg caccggtcac ttgggactga cccgctaccg
190501 cgggtattag gtacttaacg agagtaaggc ggtcctgccg ctacgtccgg cgtttggaca
190561 aacctcgatg actgcctgac ctatggcggc tgctataacc gcgagcatgc taaccagctt
190621 ggtgagtgcg gtcggatcgc atcacgtcac caccgaccct gacgtgctgg ccggccgcag
190681 cgtcgaccac accggccgct atcggggccg ggccagcgcg ctggtgcggc ccggctcggc
190741 tgaagaggtc gccgaagtgc tgcgggtgtg ccgggacgct ggagcctatg tcaccgttca
190801 aggcggccgc acctcactgg tggcgggcac cgttcccgaa cacgacgacg tgctgctgtc
190861 taccgaacgg ctttgcgtcg tcagcgatgt cgataccgtt gagcgccgaa tcgagatcgg
190921 tgccggggtc acactggccg cggtgcagca cgccgcgtca acggctgggc tggtgttcgg
190981 cgtggatttg tcggcccggg ataccgcgac cgtcggtggc atggcctcga cgaacgccgg
191041 cggattgcgc acggtccgtt acggcaacat gggcgagcag gttgtcgggc tagacgtcgc
191101 gctgcccgac ggtacggtgc tgcgccggca cagccgggtg cgtcgcgaca acaccggcta
191161 cgacctgccc gcgctgttcg tcggggccga aggcaccctg ggggttatca ccgcgctgga
191221 tctgcggctg caccccaccc cgtcgcatcg ggtgacagcc gtgtgcgggt tcgccgagct
191281 ggcagcgctg gtcgatgccg gccgaatgtt ccgcgacgtg gagggcatcg cggcgttgga
191341 attgattgac ggtcgggccg ccgcgctaac ccgtgaacat cttggcgttc gcccccccgt
191401 cgaggctgac tggttgctat tggtggaact ggccgccgac cacgatcaga ccgaccggct
191461 cgccgacctg ctcggcggtg cacggatgtg cggggagccc gcggtcggtg tggatgccgc
191521 tgcgcagcaa cggttgtggc gcacccgtga atcgctggcc gaggtgctcg gtgtgtacgg
191581 cccgccgctg aagttcgacg tctcgctgcc attgtcggcg atcagcggct tcgcccgaga
191641 tgcggtcgcg ttggttcacc gacacgtccc ggattctccg gaggcgttgc cgctgttgtt
191701 cggtcacatc ggtgagggca acctgcacct gaacgtgctg cgttgcccgc ctgatcggga
191761 accggcgttg tacgcaaaga tgatgggcct catcgccgaa tgcggcggta acgtcagttc
191821 agaacatggg gtgggcagcc gcaagcgtgc ctacctggga atgtcccggc aggccaacga
191881 cgtcgccgcg atgcggaggg tcaaggcggc gttggacccg accgggtacc ttaacgccgc
191941 ggtcttgttc gactgaccgg tgctgcgcaa gcattcagcg cctttagaga tcaccggtga
192001 aactgatgag ctgacgcacc gcgatgccat cggcgaggtg gtccatcgcc tcgttgatat
192061 cgtccaaccg aatcgttgac gtcaccagcg actccaccgg cagacggccc gattgccaca
192121 acgacacgaa gcggggaatg tcgtggctgg gcaccgccga acccagatag ctgccgatca
192181 gtgaccggcc ttcggtgaca aaatccaacg gcgacaagct gatccggaca tccggtggcg
192241 gcaacccgac ggtgatggtg cgccctccgg gcgcggtaag cccgatcgcg gtgtgcagcg
192301 cggcaggatg accgacggct tcgacaacca cggcggcttt gaccccgccg gccgtggcct
192361 gctgcggtgt gtagatctca tgggcgccca aggcctttgc ggccgacagc ttttcgggta
192421 gctgatcgac ggcgaccaca cgaacgtctg tatacgtcaa agcggtgagc accgctgcca
192481 taccgacgcc cccgaggccg acgacggcga ccgactggcc gggctgcgga tcaccgacgt
192541 tgagtaccgc acccccaccg gtgagcaccg cgcacccgag tagggcagcg acggtgggcg
192601 gcacctcgtg cggcaccgga accacgctgg cccggttgac gacgacatgg gtcgcgaaac
192661 ccgagacgcc gaggtggtgg tacaccgggc ggccgccccg gctgagccgg ataccgccac
192721 cgagcagtgt gccggccttg ttggccgcgc tgcccggttc gcacggcgtc cgaccgtcgg
192781 tcgcgcacgc cgcgcactgg ccgcaacgcg gaaggaacac cagcacgact cgctgaccga
192841 ccgcgacccc gtcgacgccg tcgccgacct gctcgacgat tccagcggct tcatgaccga
192901 gcaagatcgg caccggccgt acccgggtgc cgtcgaccac cgacaggtcg gagtggcaca
192961 cgcccgcagc ctcgattcgg acaaggacct caccgcggtc gggcgggtcc aggtgcagct
193021 cgacgacgct gattggtttc gaccgccaat agggccgcgg cacaccgatc tggtctagca
193081 ccgcgccccg gatggcaggc atgttggaat acaaccatgg ctgcactgcc ggcaccggag
193141 aagctcctgc gcagcgactt tccggtgctg tggccggtgg gaactcgatg ggccgacaac
193201 gacatgttcg gccacctcaa caacgccgtc tactaccagc tgtttgacac cgcgataaac
193261 gcctggatca acacgagcac cggggttgac ccgctcgcga tgcctgtgct gggcattgtc
193321 gcggagtcgg gctgccgtta tttctcggaa ctgcgtttcc cggagagcct aatggtgggc
193381 ctggctgtga cgcggttggg gcgcagcagc gtcacctacc ggctgggtgt gtttaaggag
193441 cctgacgatg cgggggtgat caccgcactc gggcactggg tgcacgtcta tgtcgatcgg
193501 actagccgca ggccggttcc gattcccgag gccattcggt cgctgttgtc gacggcttgc
193561 gtaagcggat aagccgcgcc cagattgcgt tcagggctgt gattttcgcc gctccaacca
193621 cagccatgac ggcaatctcg tgctcaccgc gacccaggta tgcttcccga atgccagttt
193681 tgagcaagac cgtcgaggtc accgccgacg ccgcatcgat catggccatc gttgccgata
193741 tcgagcgcta cccagagtgg aatgaagggg tcaagggcgc atgggtgctc gctcgctacg
193801 atgacgggcg tcccagccag gtgcggctcg acaccgctgt tcaaggcatc gagggcacct
193861 atatccacgc cgtgtactac ccaggcgaaa accagattca aaccgtcatg cagcagggtg
193921 aactgtttgc caagcaggag cagctgttca gtgtggtggc aaccggcgcc gcgagcttgc
193981 tcacggtgga catggacgtc caggtcacca tgccggtgcc cgagccgatg gtgaagatgc
194041 tgctcaacaa cgtcctggag catctcgccg aaaatctcaa gcagcgcgcc gagcagctgg
194101 cggccagcta aggcatgtgc gggctcagcc gaagacttcg gtctcagcca gggcctccgt
194161 cagcctgcgt gccccatcgg tgaactgcca gacggtgtgc tcgattacgg cggctgtgtc
194221 gcggcggcgc agcgcggcga tcagctgccg atgactgttc accgcgtccg cgccccatcg
194281 cgggtcggcc gcgaacacct gcgcccatat agcgcgcggc attaagcagg aaccaggcca
194341 acttgatccg gcggctcgct ttgttgaaga cgcggtggaa cgcgaactcg atcgacgcga
194401 tggttttggc atcaccggac ccgatagcac cggccagcgc attgttgatg cggtccagct
194461 cgtcgatctc aacgtcggtg atgtgagcgg tggccgatgt ggcaagttct tgggcaatgg
194521 tggcctgcag ccagaaaatg tcgtcgatgt cttggcgggt caacggcagc accacgtggc
194581 cgcgatgtgg ctccagcccg accatcccct caccgcgcag tttcagcagc gcctcccgca
194641 ccggcgtgac gctgactccg agctcggctg ccgtctcgtc gagacggatg aacgttccag
194701 agcgcagggc gcccgacatg atggcggccc gcaggtggcc cgcgacctcg tcggacaact
194761 gtgcccggcg caggggaagc tggctccgcg gcttcgccga tagaggtgcg ttcacgtggc
194821 ttgccaggac tttcagggtc gggccgggat tgccggggac ttgccggggg cttggcgggg
194881 gcttgttgtt gggccgctca ggccatagtg tgacccagac aacatcatgc tttatcaaat
194941 atcaacctgg cgcaagggat gcgcaagtga aaggaaggga aggaagggat agttgaccgc
195001 gcaactggcc agtcacctga cgcgggcgct aacactagcc caacagcagc cctaccttgc
195061 tcgccggcag aactgggtca accagctcga acggcacgcg atgatgcagc cagacgcgcc
195121 ggcgctgagg tttgtgggca acaccatgac gtgggctgac ctaaggcgcc gggttgcggc
195181 gctggcgggc gcattgagcg gtcgcggggt cggtttcggc gatcgggtca tgatcctgat
195241 gcttaaccgc accgagttcg tcgagtcggt gctggccgcc aacatgatcg gggccatcgc
195301 cgtaccactg aatttccggc tcaccccaac cgaaatcgcc gtcctggtcg aagactgtgt
195361 cgcacacgtg atgctgaccg aagctgcgct ggctccggtg gccatcggtg tccgcaacat
195421 ccagcccttg ctgagcgtga tcgtggtcgc cggcggatcc agccaggaca gcgtgttcgg
195481 ctatgaggac ctactcaacg aggccgggga tgtccacgaa ccggtggaca tcccgaacga
195541 ctcgccggcc ttgatcatgt acacctcggg caccaccggc cgcccgaagg gcgccgtgct
195601 gactcacgcg aacctcaccg gtcaggcgat gaccgcgctc tacaccagtg gcgccaatat
195661 caacagcgac gtcggtttcg tcggcgtccc gctgttccat atcgccggaa tcggcaacat
195721 gctgaccggg ctgctgctcg gcttgcccac ggtgatctat ccgctgggcg cgttcgaccc
195781 gggacagctg ctcgacgtgc tggaggcaga gaaggtcacc ggcatctttc tggttcccgc
195841 gcagtggcag gcggtctgta ccgaacagca agcacgacca cgtgacttga ggttacgggt
195901 gttgtcgtgg ggagctgcgc cggcgccgga tgcgttgctg cggcagatgt cggcaacctt
195961 tcccgaaacc cagatactgg ccgcattcgg ccagaccgag atgtcaccgg tcacctgcat
196021 gctgctcggc gaagatgcga tcgctaagcg cggatcggtc ggcagggtga tcccgaccgt
196081 cgccgcaagg gtggtcgatc agaacatgaa cgatgtcccc gtcggcgaag tgggcgaaat
196141 tgtctaccgg gcaccaacat tgatgagctg ctactggaac aacccggagg ccaccgcgga
196201 ggcgttcgca ggcggctggt tccattctgg ggatctggtt cgtatggact ccgacggtta
196261 cgtctgggtg gtggaccgca agaaggacat gattatctcc ggcggtgaaa acatttactg
196321 cgccgagctg gaaaacgttc tggccagcca tcccgacatc gccgaagtcg cggtcatcgg
196381 ccgggccgac gagaagtggg gagaggtgcc gatcgcggtc gcggccgtaa cgaacgacga
196441 ccttcggatc gaagacctag gtgagttcct gaccgaccgg cttgcgcgct acaagcaccc
196501 caaggcgctc gagatcgtgg acgctctgcc ccgcaacccc gcggggaagg tgctcaagac
196561 tgaactgcga ttgcgctacg gcgcctgtgt gaatgttgaa agacgttctg catcagctgg
196621 tttcacggag agaagggaaa accgacagaa attgtaacgt ttgcccgcta ttgacgaagg
196681 gttaaatgtg cggatgcctt acactcctgg ctggccatcg ggtagattcc tgtggtctcc
196741 gttactccct gtgagtaacg aggtggcggt cacacaccaa gggtcggggc aaggaggagg
196801 cgtgcgacat gatgcgccgc ggcgccgcga tacccaggtc ggcggcttga gggagccgcg
196861 gtgacgacgt cgacaacgct tggcggttac gtccgcgacc aactgcaaac cccgctgacc
196921 ctcgtcggtg gattctttcg catgtgtgtg ctgactggaa aggcgctgtt tcgctggccg
196981 ttccagtggc gcgagttcat tctgcagtgc tggttcatca tgcgggtcgg atttttaccg
197041 acgatcatgg tctcgatacc gctgacggtg ctgttgatct tcacgctcaa tattctgctg
197101 gcccagttcg gcgcggcaga catctccggt tccggcgcgg cgatcggcgc ggtcacccag
197161 cttggcccgc tgacaacggt gctggtggtc gccggcgccg gatccacggc catctgcgcc
197221 gacctgggtg cccgcaccat ccgcgaggaa atcgacgcga tggaggtgct gggcatcgat
197281 cccatccacc gtctggtggt gccgcgggtg ctcgcctcga tgctggtcgc cacgctgctc
197341 aacggcttgg tgatcaccgt cggcctggtc ggtggctttc tcttcggtgt ctatctgcag
197401 aacgtttcgg gcggcgccta ccttgccacg ctgaccttga tcaccggcct gcccgaggtg
197461 gtcatcgcaa ccatcaaagc cgcaacgttc ggcctgatcg cgggccttgt cggctgctat
197521 cgggggctga ccgtccgtgg cggttccaag ggtcttggca ccgccgtcaa cgagaccgtg
197581 gtgctgtgtg tgattgccct gttcgccgtc aacgtgatct tgacgaccat cggtgtgcga
197641 ttcgggacgg ggcgctgaca tgtcgaccgc tgctgtgctg cgcgcccgct tcccgcgggc
197701 ggtcgccaac cttcgtcaat atggaggtgc ggcggcccgt ggattggacg aggccggcca
197761 gctcacctgg ttcgctttga ccagcatcgg gcagatcgcg cacgcgctgc gctactaccg
197821 caaggagacg ctgcggctga tcgcccagat cggcatgggt accggcgcga tggccgtcgt
197881 cggcggcacg gtcgccatcg ttggctttgt cacgctgtcc ggcagctcgc tggtcgcaat
197941 ccagggcttc gcgtcgctgg gcaacatcgg tgtcgaggcg ttcaccgggt tcttcgccgc
198001 actgatcaac gtgcgcatcg ccggcccagt tgtcacgggt gtcgccctgg cggccacggt
198061 cggtgcgggt gctacggccg agctgggcgc gatgcggatc agcgaggaga tcgatgccct
198121 ggaagtgatg ggcatcaagt cgatctcgtt tctggcctcc acccggatca tggccgggct
198181 ggtggtgatc atcccgctgt acgcgttggc gatgattatg tcgttcctgt ccccgcagat
198241 caccaccacg gtgctctacg ggcagtcgaa cggcacctac gagcattact ttcaaacgtt
198301 cctgcgtccc gacgatgtct tttggtcctt cttggaggcc ctcatcatca ctgcgatcgt
198361 catggtcagc cactgctact acgggtacgc cgccggtgga ggccccgtcg gtgtcggcga
198421 ggccgtcggc cgatcgatgc gtttctcgtt ggtctcggtg caggtcgttg tcctgtttgc
198481 agcgttggcg ctctacggtg tcgacccgaa cttcaatctc acggtgtagc cgcatgacga
198541 cgccggggaa gctgaacaag gcgcgagtgc cgccctacaa gacggcgggt ttgggtctag
198601 tgctggtctt cgcgctcgta gttgccttgg tatacctgca gtttcgcggg gagttcacgc
198661 ccaagacgca gttgacgatg ctgtccgctc gtgcgggttt ggtgatggat cccgggtcga
198721 aggtcaccta taacggggtg gagatcgggc gggtagacac catctcggag gtcacacgtg
198781 acggcgagtc ggcggccaag ttcatcttgg atgtggatcc gcgttacatc cacctgattc
198841 cggcaaatgt gaacgccgac atcaaggcga ccacggtgtt cggcggtaag tatgtgtcgt
198901 tgaccacgcc gaaaaacccg acaaagaggc ggataacgcc aaaagacgtc atcgacgtac
198961 ggtcggtgac caccgagatc aacacgttgt tccagacgct cacctcgatc gccgagaagg
199021 tggatccggt caagctgaac ctgaccctga gcgcggccgc ggaggcgttg accgggctgg
199081 gcgataagtt cggcgagtcg atcgtcaacg ccaacaccgt tctggatgac ctcaattcgc
199141 ggatgccgca gtcgcgccac gacattcagc aattggcggc tctgggcgac gtctacgccg
199201 acgcggcgcc ggacctgttc gactttctcg acagttcggt gaccaccgcc cgcaccatca
199261 atgcccagca agcggaactg gattcggcgc tgttggcggc ggccgggttc ggcaacacca
199321 cagccgatgt cttcgaccgc ggcgggccgt atctgcagcg gggggtcgcc gacctggtcc
199381 ccaccgccac cctgctcgac acttatagcc cggaactgtt ctgcacgatc cgcaacttct
199441 acgatgccga tccgctcgct aaagcggcgt ccggtggcgg taacggctac tcgctgagga
199501 cgaactcaga gatcctatcc gggataggta tctccttgtt gtctcccctg gcgttagcca
199561 ccaatggggc ggcaatcgga atcggactgg tagccggatt gatagcgccg cccctcgcgg
199621 tggccgcaaa tctagcggga gccctacccg gaatcgttgg cggcgcgccc aatccctata
199681 cctatccgga gaatctgccg cgggtgaacg ctcgcggtgg cccggggggc gcccccggtt
199741 gctggcagcc gatcacccgg gatctgtggc cagcgccgta tctggtgatg gacaccggtg
199801 ccagcctcgc cccgtacaac cacatggagg ttggctcgcc ttatgcagtc gagtacgtct
199861 ggggccgtca ggtaggggat aacacgatca acccatgaaa atcactggaa ccgtcgtcaa
199921 actcggcatc gtctcggtgg tgctgctgtt cttcacggtg atgatcatcg tgattttcgg
199981 tcagatgcgc ttcgaccgga ctaatggcta taccgcggag ttcagcaatg tcagcgggct
200041 gcgccaaggc cagtttgtcc gtgcttcggg ggtagagatc ggcaaggtca aagcactaca
200101 cctggtcgac ggtggccgtc gggttcgggt ggagttcaat atcgatcgtt cggtgccgtt
200161 gtatcagtcc acgaccgccc agatccgcta ttccgacctg atcggtaacc ggtacgtgga
200221 gctcaaacgg ggtgagggca agggggccaa cgatctgctg ccgccaggtg gactcatccc
200281 attgtcccgc acgtcaccgg ccttggatct ggacgcgttg atcggtggtt tcaagccggt
200341 gtttcgggcg ttggatcccg cgaaggtgaa caacatcgcc aacgcgctca tcaccgtctt
200401 ccaggggcaa ggtggcacca taaacgacat cctcgaccag accgcgcaac tgaccagcca
200461 gatcgcggag cgcgatcagg cgatcggtga ggttgtcaag aacctgaaca tcgtgctgga
200521 caccacggtc aagcatcgaa aagagttcga cgagacggtc aataacttgg agaatctgat
200581 cactgggctg aggaaccact ccgaccagtt ggccggcggc ctcgcgcaca tcagcaacgg
200641 cgccggcacg gtggccgacc tgcttgccga gaatcgcacg ttggtgcgca aggccgtcag
200701 ctacctggac gctattcagc aaccggtcat cgaccagcgc gtcgagttgg acgacctgct
200761 ccacaagacg ccgaccgcgt tgacggcgct cggacgcgcc aacggaacct acggcgattt
200821 ccagaacttc tacctctgcg acctccagat caagtggaac ggattccaag ccggagggcc
200881 ggtccgcacg gtgaagctct ttagccagcc gacgggtagg tgcacgccgc aatgagaacg
200941 ctggaaccac ccaaccgaat gcgaattggg ctcatgggca tcgtcgttgc gctgctcgtt
201001 gtcgctgtgg gccaaagctt taccagtgtt cccatgctat tcgcaaagcc gagctactac
201061 ggccagttca ccgactccgg cggactgcac aagggcgaca gggtacgcat cgccggcttg
201121 ggagtgggca ccgtggaggg gctcaagatc gacggcgacc acatcgtggt caagttctcc
201181 atcggcacca acaccatcgg caccgagagc cgcctagcca tccgcaccga caccatcctg
201241 ggtaggaaag tgctcgagat cgagccgcgc ggcgcccaag cgttgccgcc cgggggcgtt
201301 ttgccggttg ggcaaagcac caccccgtac cagatttacg acgcgttctt cgacgtcacc
201361 aaggccgcat ccggctggga catcgagacg gtcaagcggt cgctgaatgt gttgtcggag
201421 accgttgatc agacctatcc gcacctgagc gccgccctcg acggggtggc taagttctcc
201481 gacaccatcg gcaagcgcga cgagcagatc acgcacctac tagcccaggc caaccaggtg
201541 gccagcatcc tgggtgatcg cagtgagcag gtcgaccgcc tattggtcaa cgctaagacc
201601 ctgatcgccg cgttcaacga gcgcggccgc gcggtcgacg ccctgctggg gaacatctcc
201661 gctttctcgg cccaggtgca aaaccttatc aacgacaacc cgaacctgaa ccatgtgctc
201721 gagcagctgc gcatcctcac cgacctgttg gtcgaccgca aggaggattt ggctgaaacc
201781 ctgacgatct tgggcagatt cagcgcgtcg ttcggtgaga cgtttgcctc tgggccctac
201841 ttcaaagtgc tgctggccaa cctggtgccg ggtcagatct tgcagccgtt tgtcgatgcg
201901 gcattcaaga agcgtggtat tagcccggag gacttctggc gcagcgccgg gctgccggca
201961 taccggtggc ccgaccccaa tggcacccgg ttccccaacg gtgcgccgcc gccaccaccg
202021 ccggtgttgg agggcacgcc cgagcatccc gggccggcgg tgccgccggg atcgccgtgc
202081 tcctacaccc cgccggcgga cggtctgccg cggccgtggg atccgctgcc ctgcgctaac
202141 ctcactcaag gtccattcgg tggccccgat ttcccggcgc cgctggatgt cgcgacgtcg
202201 ccgccgaacc cagacggtcc accgcccgcc ccgggcctac caatcgcggg acgtccgggt
202261 gaggtgccgc cgaacgttcc cggcacgccg gtgccgattc cacaggaggc tccccccggg
202321 gcacgcacgc tgcccctcgg gccggcgcct ggtccggctc cgcccccggc ggcgccaggc
202381 ccgccggcac caccgggccc cgggccgcag ttgccggccc cgttcatcaa ccccggcggc
202441 accggcggta gtggcgtgac gggaggtagc gagaattgag caccatcttt gatatccgca
202501 acctgcggtt gccgcagctg tcgcgggcct cggttgtcat cggatcgttg gtggtggtgc
202561 tggcgctggc cgccggaatt gttggtgtgc ggctctatca aaaactgacg aacaacacgg
202621 tggtcgccta cttcacccaa gccaatgcgc tgtatgtcgg agacaaggtc cagattatgg
202681 gcctcccggt cggttcgatc gacaagatcg aaccagccgg cgacaaaatg aaggtgactt
202741 tccactacca gaacaagtac aaggtgcctg ccaatgcctc cgcggtgatc ctcaacccca
202801 ccttggtggc gtcgcggaac attcagttgg agccacccta cagaggtggt ccagtgctgg
202861 ccgataatgc ggtgatcccg gtcgagcgca cccaggtacc gacggagtgg gacgagctgc
202921 gggacagcgt ttcgcatatt atcgacgagc tcggcccgac acctgagcag cccaaggggc
202981 cgttcggcga agtcatcgag gcattcgccg acgggctggc cggcaagggt aagcaaatca
203041 acaccacgct gaacagcctg tcgcaggcgt tgaacgcctt gaatgagggc cgcggcgact
203101 tcttcgcggt ggtacgcagc ctggcgctat tcgtcaacgc gctacatcag gacgaccaac
203161 agttcgtcgc gttgaacaag aaccttgcgg agttcaccga caggttgacc cactccgatg
203221 cggacctgtc gaacgccatc cagcaattcg acagcttgct cgccgtcgcg cgcccgttct
203281 tcgccaagaa ccgcgaggtg ctgacgcatg acgtcaataa tctcgcgacc gtgaccacca
203341 cgttgctgca gcccgatccg ttggatgggt tggagaccgt cctgcacatc ttcccgacgc
203401 tggcggcgaa cattaaccag ctttaccatc cgacacacgg tggcgtggtg tcgctttccg
203461 cgttcacgaa tttcgccaac ccgatggagt tcatctgcag ctcgattcag gcgggtagcc
203521 ggctcggtta tcaagagtcg gccgaactct gtgcgcagta tctggcgcca gtcctcgatg
203581 cgatcaagtt caactacttt ccgttcggcc tgaacgtggc cagcaccgcc tcgacactgc
203641 ctaaagagat cgcgtactcc gagccccgct tgcagccgcc caacgggtac aaggacacca
203701 cggtgcccgg catctgggtg ccggatacgc cgttgtcaca ccgcaacacg cagcccggtt
203761 gggtggtggc acccgggatg caaggggttc aggtgggacc gatcacgcag ggtttgctga
203821 cgccggagtc cctggccgaa ctcatgggtg gtcccgatat cgcccctccg tcgtcagggc
203881 tgcaaacccc gcccggaccc ccgaatgcgt acgacgagta ccccgtgctg ccgccgatcg
203941 gtttacaggc cccacaggtg ccgataccac cgccgcctcc tgggcccgac gtaatcccgg
204001 gtccggtgcc accgacgccg gcaccggtgg gggcgccgtt gcccgctgag gcaggagggg
204061 gtcaatgatg agcgtgctgg cgcggatgcg ggtgatgcgc caccgagcct ggcaggggct
204121 ggtgttgctg gtgctcgcac tcttgctgag ttcgtgcggc tggcgcggca tctccaatgt
204181 ggcgatcccc ggcggcccgg gcaccggccc gggctcctac accatctacg tgcagatgcc
204241 ggacacgttg gcgatcaacg gcaacagtcg ggtcatggtg gccgacgtct gggtcggatc
204301 gatccgcgcg atcaagttga agaactgggt ggccacgctg acgctgagcc tgaagaagga
204361 cgtcacgcta ccgaaaaatg ccaccgccaa gatcgggcag accagcctgc tgggttcgca
204421 gcacgtcgag ctggccgcgc cgccagatcc gtcgccggtg ccgctgaagg atggtgacac
204481 catcccgttg aagcgctcct cggcctatcc caccaccgag cagacgctgg ccagcatcgc
204541 caccttgttg cgcggcggcg gcctggtgaa cctcgaaggg attcagcaag agatcaacgc
204601 catcgtgacg gggcgggcgg accagatccg ggcctttctt ggcaagctcg acaccttcac
204661 cgacgagctc aaccagcaac gcgatgacat tacccgcgcc attgattcca ccaatcggtt
204721 gttggcttat gtgggcggtc gttcggaagt cctcaatcgg gtgctcaccg acctaccgcc
204781 attgatcaag cactttgcgg ataagcagga actgttgatc aacgcttccg atgcggtagg
204841 ccggctcagc cagtccgccg accagtatct ttcggctgcc cggggcgatc tgcaccagga
204901 cctgcaggcg ctgcaatgcc cgctcaagga actgcgtcga gccgctccgt atctggtggg
204961 tgcgctcaaa ttgatcctca cccagccctt tgacgtcgac accgtgccgc agctggtgcg
205021 gggcgactac atgaacttgt cgctgacgct ggacctgacc tacagcgcca tcgacaatgc
205081 gttccttacc gggaccggat tctccggtgc gttgcgcgcc ctcgagcagt cttttggccg
205141 cgatcccgag acaatgattc ccgacatccg gtacacaccg aaccccaacg atgcgccggg
205201 cggcccgctg gtagaaaggg gaaatcgcca gtgctgactc gcttcatccg acgccagttg
205261 atcctttttg cgatcgtctc cgtagtcgca atcgtcgtat tgggctggta ctacctgcga
205321 attccgagtc tggtgggtat cgggcagtac accttgaagg ccgacttgcc cgcatcgggt
205381 ggcctgtatc cgacggccaa tgtgacctac cgcggtatca ccattggcaa ggttactgcc
205441 gtcgagccca ccgaccaggg cgcacgagtg acgatgagca tcgccagcaa ctacaaaatc
205501 cccgtcgatg cctcggcgaa cgtgcattcg gtgtcagcgg tgggcgagca gtacatcgac
205561 ctggtgtcca ccggtgctcc gggtaaatac ttctcctccg gacagaccat caccaagggc
205621 accgttccca gtgagatcgg gccggcgctg gacaattcca atcgcgggtt ggccgcattg
205681 cccacggaga agatcggctt gctgctcgac gagaccgcgc aagcggtggg tgggctggga
205741 cccgcgttgc aacggttggt cgattccact caagcgatcg tcggtgactt caaaaccaac
205801 attggcgacg tcaacgacat catcgagaac tccgggccga ttttggacag ccaggtcaac
205861 acgggtgatc agatcgagcg ctgggcgcgc aaattgaaca atctggccgc acagaccgcg
205921 accagggatc agaacgtgcg aagcatcctg tcccaggcgg cccccaccgc cgatgaggtt
205981 aacgcggtat tcagcggtgt tcgcgattcg ctgccacaga ccctggccaa tcttgaggtt
206041 gtgttcgata tgctcaagcg ctaccacgcc ggcgtggagc aattgttggt gttcctccca
206101 cagggtgccg cgatcgcaca gaccgtactc acgccaactc cgggtgctgc ccagctgccg
206161 ctcgcgccgg cgatcaacta tccgccgccg tgcttgacgg gttttcttcc tgcatcggag
206221 tggcggtctc cggccgatac cagtcccagg ccgttgccgt cgggaaccta ttgcaagatt
206281 ccccaggatg cccagctgca agtccggggg gcgcgcaaca ttccctgtgt cgatgtcctg
206341 ggcaaacgag cggcgacgcc gaaggagtgc cgcagtaagg acccgtacgt tccgctgggt
206401 accaacccgt ggtttggtga tccgaaccag attctcacct gcccggcacc tggagcgcgc
206461 tgcgatcagc cggtgaagcc cgggttggtg attccggcgc cctcgatcaa caccggtttg
206521 aatccggcgc ccgccgatca ggtgcaagga acgcccccgc cggtcagtga cccgttgcaa
206581 agaccgggtt cgggtactgt gcagtgcaac gggcagcagc ctaacccgtg cgtctacact
206641 ccaacatcgg gcccgtcggc ggtctatagc ccggccagcg gtgaactggt ggggccggat
206701 ggtgtcaagt acgccgtcgc aaactcgagc acaacaggag acgacggatg gaaggagatg
206761 ctggcgccgg ccagctgaac cctgccgatg cgaataagtc gtcgtctacg gaggtgaagg
206821 cggcggattc ggcggaatct gacgccggag ccgaccagac tggcccgcag gtgaaggcgg
206881 cggattcggc ggaatctgac gccggagagc tcggcgagga cgcgtgccca gaacaggccc
206941 tcgtcgagcg gcgcccgtcg cggttgcggc gaggctggct tgttggcatt gcggcgacgc
207001 tgctcgcgtt ggccggtggc cttggcgcag cgggttattt tgcgttgcgc tcacaccagg
207061 aaagccaatc aatcgcgcgc gaggaccttg cggccattga ggccgctaag gattgcgttg
207121 cggccacgca ggcacccgat gctggggcga tgtcggctag catgcagaag atcatcgagt
207181 gtggcaccgg tgatttcggt gcccaggcgt cgttgtacac cagcatgctc gtcgaggcgt
207241 atcaagcggc cagcgtccac gtgcaagtga ccgatatgcg cgcggcggtc gagcgcaaca
207301 acaatgacgg gtcggtcgat gttctggtgg cgctccgggt caaggtgtcc aacaccgact
207361 cggatgccca tgaagtcggc taccgtcttc gggtccggat ggcactggat gagggccgct
207421 ataagatcgc caaactcgac caggtgacga agtgacggtg gtggtcgaga agacgccgac
207481 caccctgccc caggcgacac cgaacggtgc agcgccctgg catgttcggg cgggcgcctt
207541 cgccatcgac gtgctgcccg ggctcgccgt ggcggcgacc atggcgttga cggctttaac
207601 ggtgccgccg ggcagcgcgt ggcggtggtt atgcgcttgt ctgctcggat tgaccattct
207661 ccttctggcc gttaaccggt tgttgttgcc gacgattacc ggatggagtc ttggccgcgc
207721 tcttaccggc atccgggtgg ttcggcgtga cggctccgcc atcggtccgt ggcggttgct
207781 ggtccgggat ttggcgcact tggtggacac cctctcgctg tttgtgggtt ggctgtggcc
207841 gctgtgggat tcgcggcgac gcaccttcgc cgacctgttg ttgcgcactg aggtgcgacg
207901 tgtcgaaccg gtgcagcggc ccgcggtgat acggcgactg acggcggcgg tggcattggc
207961 ggcggcgggc gcgtgcgcga gcgcaaccgc ggtgggcgct gcggtggtgt acgtcaatga
208021 atggcaaacc gatcacactc gcgcgcagct cgcaacgcgg ggcccgaagc tcgtggtcga
208081 cgtcctgagc tacgaccccg aaacggtgca gcgtgatttc gaacgggcgc gatcgctggc
208141 caccgacagg taccgcccgc agctgagcat ccaacaggat tcggtgcgcg agtcgggacc
208201 tgttcgtaac cagtactggg ttaccgacag cgcggtgctg tcggcgacac cagctcaggc
208261 gaccatgctg ttgttcatgc agggtgaacg cggtacacca cccaatcagc ggtatattca
208321 gtcaactgtg cgggcgatct tccaaaaatc gcgcgggcaa tggcgcctcg acgatctggc
208381 agtcgtgatg aaaccccgac aacccaccgg cgaaaaatga gcccccgtcg taagtttgaa
208441 cccggcgagg gggcgctgct ggccccgcag tcaatcgaac cgtcgcggcg atggggtttg
208501 ccgctggctc tgaccgcatc cgctgtggtt atggccgcgg cgatctcagc ctgtgcgctc
208561 atgcggatct cccatgaatc gcaccagcga gcagcgcaca aggatatcgt gatgctcagt
208621 gatgtccgat ctttcatgac catgttcacg tcaccggatc cgtttcacgc caacgaatat
208681 gcggagcggg tgctgtccca cgccacgggc gacttcgcca agcagtacca cgaaagagca
208741 aacgatatcc tgattcgcat ctccggggtg gaaccgacca caggaacggt tctagacgcg
208801 ggcgtacaga ggtggaacga ggatggtagt gccaacgtgc tggtggtcac ccagatcacc
208861 tcgaaatccg cggacggcaa gcgggtggtc tcgaacgcca atcgttggct ggtaacggct
208921 aagcaggaag gtaacgagtg gaagatcagc agtctgcttc cggtgatctg acccaaaagt
208981 ccgttgccaa cggagagtcc accgacacgg catccgcagc caccgagggc caccggggcg
209041 agatcgacgc cgcgggagag ccggacgaac gcggtgccgc cgtggctgac agccaagctg
209101 acgaggatga ttcggccgcg acggctgcca ggggcggcaa gacacgggca agacgatcgc
209161 gtggcaggcg gttagcgatc acggtcggcg tggccgctgc gttgttcgtg ggctcggcag
209221 cgttcgctgg tgcgacggtg gagccctacc tctccgagcg cgccgtggtg gccaccaagc
209281 tcatggtcgc gcggaccgcc gccaatgcga tcacgacgtt gtggacctac acgccggaga
209341 acatggacac cctggccgat cgggccgcga attacctcag cggtgatttc gcggctcagt
209401 accgcagatt cgtcgaccag atcgccgcag caaacaaaca ggccaagatt accaacgata
209461 ccgaggtcac cggtgctgcc gtggaatcgc tgagcggccg ggatgccgtt gccatcgtct
209521 acaccaacac cacgaccacc agtccggtga ccaagaacat cccagcattg aagtatctgt
209581 cctaccggct gttcatgaag cgttatgacg cgcggtggct ggtgaccagg atgacgacca
209641 tcacctcgct ggatttgacg ccgcaggtgt agcgggaccg agcccgccgg cgctgcgaag
209701 ccttagttga acgccagcca gctgggcagc gcccgctcat gggagtcaca gagcacctga
209761 cgggtgtcgc acgatccttt cggcgaccca gcgccggccc acatgccccc ggtatcacgg
209821 cgcagaacga tcgccgatga ccccccgccg tcgagcagaa tcgcggtgtc actacccagg
209881 ccgcggaaca ggtcttggat gttgtccggg gtgtagttgc cgccctggaa gatgtacatc
209941 tcgtccttct gcttcgcata ggcaagcgcc gttcgcgcgg cgctgggacc gccgtcgtgg
210001 agctggccgg tattgccggg ggataacagc ccgattccgg ccacggcgac gaaccgtgca
210061 ttcttgttga gcaagtcctc gatcaccgga gtggcaagat cgtagtcctg tctgcttttg
210121 ggccgcaaaa catacggtgc accaccgacc ggaaggatca tcgtcgtcag cgagctccac
210181 aactcatttc ctccggaaag gccctgcttt ccggcgtagg cgacggtgcc ggtgaccgct
210241 tggttggcgc gtccttgtcc gcgggtgttg tccacgtagg cgcccagcgg tgagctgcag
210301 ccggtcgacc gccagctgcc ccccttttgt ccgcgaacgt cgaagaagtt ggcgttgacc
210361 gcaatggtgg gtcgccccat acgctgccac gccttaagcg gcgggtagat ctcggaggct
210421 tgccacaagc cttcaccggt gcgagcacct gggttgtgtt cgcagcgcgc ctggtctcca
210481 gtgtgggtgt ctaccagtag atgtggtgaa agccgttggg aggcattctt gatgatcatc
210541 agatggccgc cgttgttcat ctcgtaccag tgaccacctg cgttgagcag cggcatagga
210601 tgaccgccgc cgaagttgta caccaggtat gagcccctgg tggtggctat cgcttgggcg
210661 agcatctcgc gcccgtcggc ggcgcgggcg gccggctgcc cggtggtgca ggcgagggcg
210721 gcgcacaccg ccaacgcggc gtagcaagcc gtcaatcggc gcaggctggc agtcggtgtc
210781 agcacagcaa ccctctcggc ccgaatccac atgcaaccat cccagcatta ggcacactga
210841 tcacactgtc aacttcagta acagctgcgt gacggttcgg ccgcgttcga attacggttg
210901 ttcgcttgag ctttcgcgtg cgctttggcg agcttggtat tgagcttggt gttccacggc
210961 gatcgccatc tcgaccgctc ccggaattcg gtggaagctg ctgcggtcgt acaggtgtgt
211021 gatgaatcca cccagcaaca gcccgatgat cagcccgatc gacgtcatgg tcagggcctg
211081 ggacaggccg gcgtcggcgt ttccgttcag atacagcagt gaccgcacac ctaggaacac
211141 ctggtgcatc ggctcgaatt gagccaacca gcggaagaac gctggtacgg cttccagcgg
211201 gacggtcgcg cccgccgacg gcaatccgag gatgacgaag atcaacatgc tgaccaacag
211261 gcccatcgag cccagcaccg cgatcagcga gctggacgtg acgccgaccg ctatgatcgc
211321 gaatactccg tagagccata cttgccaccc gagcggaatc ggcatgccca ggccgtgggc
211381 gatcgccagg tagacacccg aggtgagcaa cgccagcacc accatcaccg cccacttgac
211441 caacagcgta cggaagcgag agatgttgac ctgctcggcg aagcgataga cggggccgaa
211501 ttcggctggt acatagccaa gcatcgagtc caccagggtg ctcaccacga tgctgccggt
211561 aaagcccgcc aatagcagca agagggcgta gtaaaacgcc gacagcccgt tgccggtgcc
211621 gttgggcagt gggttatagg cggtggattt gacatcgatg ggactggcca gcccggccgc
211681 cgccgccccg gccagtgcca caccgccggt ctgggccgct acctccgcgg taagtcgctc
211741 gcccactttg ccgttgacca ccgtcagtgc ccgggtcagc gtctggccgg cgatgctagc
211801 tgccagcgtg cccgcccgcg gattcgttga gatcgtgatc gcgggccggt ctgtgcgggt
211861 tggcgtcacc gcactcgccc cgaagtcccg tagctgcgac gagaaggtcg gcggtatcag
211921 cgccgagccg tacaccgccg cggtgtcgag cagccgcctg gcctcgtccg gcgaaaccac
211981 tcggatgtcg aacttgttct tgtccaagcc ggaaaccaga ccgtcgacaa tctgctggcc
212041 cgcgggcccg gcgtcctcgt tcaccaacgc gattgggaaa tgccgcaaat tggtcatggg
212101 gtttaggatg ccgcccagat agagcgcggc cagcgccgac atcagggcca acgtggtggc
212161 gatcggtgcc atccagaaac gcaccgtccg aatcgctttg acgttccgct tggggttggg
212221 tgcggcgggg cgcggctgcg cttgagacat gcgggctcct gtctgtcgtg gccactctat
212281 gttgccgaat cgcccagctt cgcgtgcatc tcccagatca gtacttccga cggctcattg
212341 gcggtcaggc cgcgggcgtc agcgtcggtg aaccgcaccg cgtccccgtc ggcaagctcg
212401 ccgccacctt ccagagtgag gcggccgtag gcgacgaaca gatgcaggaa gggtgcgcag
212461 ggcaggctga ccgtagcgcc gggccgcagc cgcgcgccgt gcaacgaggc gctgctgtta
212521 tgcagggtga gcgctgcgtc ttgcccgggt atgcccgacg cgatggttac caggccggcg
212581 cgcaacagtt cgtcgtctat ctcctgctgt tggtagctgg cagtgatgcc ggttgcatcg
212641 ggtattaccc acatctgcac gaaatgcacc ggctcggtag cagaatcgtt catttccgaa
212701 tgcaagattc cggtgccggc cgacatgcgt tgggccagac cgggatagat cactccgcta
212761 ttgccggcgg aatcctggtg tctgagcgct ccccgcagca cccaggtcac gatttccatg
212821 tcacggtgtg gatggggatc aaaacccgaa gccggttcca tttggtcgtc gttgttcacc
212881 aacaggagcc cgtggtgggt gttgtcggga tcgtagtggt cgccgaatga gaacgaatgc
212941 cgggatttca gccaggacgt cgtggtgacc gcccggtcgg ccgcacgcct tatctcgacg
213001 gtggcggtca tgacgtcacg ttcgccatca cagcgaatcg ggcaggccga atttcgggaa
213061 caaggtggtg tcgaggaagg ccaccacgtg tgacacgcgg tcggcggcca tgtccagcac
213121 gtgtagctga aaaggcaggt gcacgtcacc ggcacgcatg tacatggccg cggcgggctg
213181 gccgttggcg atcaacgaaa tcaggcgcat atcgccaggc gaataggcgg ggcactgttg
213241 gtgaatgagg gtgacgatgg cctgtgcgcc ctggtaccag ccggtatacg gcggcatttc
213301 ccagatcgcc tcggcggtga acagctcgac caaccggtcg atgtcataag cctcgaacgc
213361 ggcgatatag cgggccaaca ggtcttgcgc ctcgggtgaa tccggcgcgg acaaccggtc
213421 ggcggcgctg ggccggaccg tctgcagctg agagcgggcc cgctgcagca ggctattgac
213481 ggcgacggtg ctggtaccga tcgcgtcggc cacctcggcc gatttccact gcagcacgtc
213541 gcgcagcagc agtacggctc gctgccgggg tgagaggtgc tgcagagccg ccacaaaggc
213601 caaccgcacc gattcccggt tcccgacgat cgttgaggga tcagcagggt cgtccgtcac
213661 gtccggcagc ggctccagcc aggacacctc tcgacgttcc accaactccc cggacggatc
213721 ggcactcggc cgcccgagcc ccgtcggcaa cggccggcgt cgacggccct ccaacgccgt
213781 caggcaggtg ttggtggcga tccgatgcag ccaggtgcgt agcgaggact tgcccgcgaa
213841 gccctcatag gccttccagg cccgcagcag cgtctcctga acaaggtctt ccgcgtcgtg
213901 cagcgagcca gtcatgcgat agcagtgtgc gagcagttca cgccggtagg gctcggtgtg
213961 ggcggagaag tccccgcgcc gttcgtcggc gggctcgcgg ccagagtttt ctgcgagcac
214021 actcacgtca atgagcctac gcagagtctc cgacactctc accggagcag ccgttacgct
214081 cccggtaatg actaccaccc ggactgaacg gaatttcgcg ggcatcggcg atgtgcgcat
214141 cgtctacgac gtctggacgc cggacaccgc gccgcaagcg gtggtcgtgc tggcccatgg
214201 tctgggcgag catgcccgcc gctacgacca tgtcgcgcag cggctcggcg cggccggcct
214261 ggtcacctat gcgcttgacc accgcgggca tggccgctcg ggtggcaaac gggtgctagt
214321 gagagacatc tccgagtaca ccgctgactt cgacaccctc gttgggatcg ccacccggga
214381 atatcccggg tgcaagcgca tcgtgctcgg gcacagcatg ggcggcggca ttgtgttcgc
214441 ttacggtgtc gaacgtccag acaactacga cctgatggtg ctttcggcgc cggcggtggc
214501 ggcacaggac ctggtgagcc cggtagtggc ggttgccgcc aagcttctgg gcgtcgtggt
214561 gcccggcctg ccggtgcagg aactggattt tactgccatc tctcgcgacc ctgaggtggt
214621 ccaggcttac aacaccgacc cactcgtgca ccacggacgg gttccggccg ggattggccg
214681 cgcgctgctg caggtgggcg agaccatgcc gcggcgagca ccggcattga ccgcgccgct
214741 gctagtgctg cacggcaccg atgaccggct gatccccatc gagggcagcc gtcgcctggt
214801 cgaatgtgtg ggatcggccg acgtgcagct gaaggagtat cccgggctgt accacgaggt
214861 gttcaacgag ccggagcgca accaggtgct cgacgatgtg gtcgcctggc tcaccgagcg
214921 gttgtaggcc gagccgacct gtcgcagccc tccactagtt ttggcgccat gaccaacgac
214981 aagatgctgg cccgcatcgc agccctgctg cgccaggccg aaggcaccga caacccgcac
215041 gaggccgacg cgttcatgag caccgcacaa cggttggcca cggcggcatc catcgacctg
215101 gcggtggccc ggtcgcacgc gggcaaccgt tcacccgcgc aggccccgac acagcgcacc
215161 atcaccatcg gggcggcggg cacccgcgga ttgcggacct atgtgcagct cttcgtgctc
215221 atcgcggcgg ccaacgacgt gcgctgcgac gtggcatcga attcgacgtt cgtgtacgcc
215281 tacgggttcg ccgaggacat cgacaccagc cacgccctat acgccagcct ggtggtccag
215341 atggtccggg catccgacgc ctacctcgcc tcgggagcgc accggcccac gccgacgatc
215401 accgcccgac tcaacttcca gctggcgttc ggcgcccggg tcggccagcg cttggccgat
215461 gcccgagagc agactcggca ggaagccacc aaggaccgtg atcgtccgcc tggtaccgca
215521 attgccctgc gggacaagga catcgagctg catgagtact accgtcgttc ctctaaggcg
215581 cgcggcgcct ggcgagccag ccgggccacc gcgggatact cgtcggcggc acggcgcgcc
215641 ggtgatcgag cgggacggca agcacgactc gggaacaacc ccgagctgcc cggggcacgg
215701 gccgcgctgg gccggtgatc ggcgcggacg ttccgcggga ttcccagcgt gccagggtgt
215761 acgcggccga ggcgttcgtc cggaccttgt tcgaccgcgt caccgcacac ggctcaccga
215821 cggtggagtt cttcggtacc cagttgacgc tgcccccaga aggtcggttc ggttcggtgg
215881 catcggtgca gcgttatgtg gacgacgtgc ttgcgctacc ggcggtaggg cagaactggc
215941 cgacggtgtc gccggtgcgc gtgcgggcgc gccgggcggc caccgcggcg cactatgaaa
216001 accatggcgg cacaggcact attgcggtac ccgaccggca caccgccggt tgggcgatgc
216061 gcgagttggt cgtgctacac gaagtggcgc atcatttgtg ccaggtgcca ccgccacacg
216121 gacccgagtt tgtggcgacg gtgtgcaccc tgacagagct ggtgatggga cccgaagttg
216181 gtcacgtgtt tcgcgtcgtc tacgcgcagg agggcgtgcg ctgaacgagc tagacgccga
216241 cctgcgggca cgtgaggtcg aggcccagat gaccgacgac gagcgattct cactgttggt
216301 cggcctgacc ggggccagcg atctgtggcc ggtgcgcgat gaacgcatcc cacagggcgt
216361 gccgatgtgt gccgggtatg tgccggggat tccccggctc ggggtcccgg ccttgttgat
216421 gagcgatgcc ggtctgggcg tcaccaaccc tggctaccgc cccggtgaca ccgctacggc
216481 gctgcccgcc ggccttgccc tagcggccag ctttaacccg gtgctggccc ggtcctcggg
216541 caaagcgatc ggccgggagg cgcgcagtcg cgggttcaac gtgcaactgg ccggcgcaat
216601 caatctggcg cgcgacccgc gtaacggccg caacttcgag tacctttccg aggacccgtt
216661 gttgagtgcc acgatggccg cggagtcgat catcgggatt cagcagcagg gtgtcattgc
216721 gacgacgaaa cacttctcgc tgaactgcaa cgaaaccaat cggcactggc tggacgcggt
216781 catcgatccc gacgcgcacc gcgagtcgga cttgttggcg ttcgagatcg tcatcgagcg
216841 gtcgcagccc ggcgccgtga tggcggcgta caacaaggtc aacggagatt acgctgccgg
216901 caacgaccac ttgctcaacg acgtgctgaa aggtgcttgg ggataccgcg gttgggtgat
216961 gtcggattgg ggcggaacac ccagctggga gtgcgcgctg gccggcctgg accaagagtg
217021 cggtgcgcag atcgatgcag tgctgtggca gtcggaagca ttcaccgacc gcctgcgtgc
217081 cgcctacgcc gacggcaatc tacccaaggg gcgcctgtcg gacatggtac ggcggatcct
217141 gcggtcgatg tttgccgtcg gaatcgaccg atggaaacca gcgccggcgc cggacatgaa
217201 tgcgcacaac gagattgccg cacagatggc gcggcaagga atcgtgctgc tgcaaaaccg
217261 agggctgctg ccgctcgctc ccgaatcggc cgggcgtatt gccgtcatcg gcggctatgc
217321 acacctcggt gtgccagccg gttacggttc gagcgccgtc accccgccgg ggggctatgc
217381 gggcgtgata ccgatcggtg ggtctggctt ggcagccggg ttgcgtaatc tctacctgct
217441 gccgtcaagc ccgctgagtg agttgcgaaa gcggttgccc aacgcgcagt tcgagttcga
217501 tcctggcatc aacccggcgg aggcggtgct ggctgcgcgg cgagcagaca tcgcgatcgt
217561 gttcgcgatc cgtgccgaag gagagggctt cgacagcgcc gatctgtcgc tgccatgggg
217621 tcaggatgcg ctgatcgccg cagtcgcgtc cgccaacgcg aataccgttg tggtgcttga
217681 gacgggcaac ccggtgacca tgccctggcg cgactcggtg aacgccatca tgcaggcctg
217741 gtatccgggc caggcgggtg gccaggccgt tgcggagatt gtgaccgggc aggtgaatcc
217801 ttcgggccgg ctgccgatca ccttcccggt cgatctcggt cagacgccac gctcgcaacc
217861 gcccgagctc ggtgccccgt gggggacatc gaccacgatc cactacaccg agggcgccga
217921 tgttggttac cgctggtttg ccagcacaaa tcagaccccg atgttcgcgt tcggtcacgg
217981 cttgtcctat accagtttcg agtatcgtga cctggtggtg acgggcggcc acaccgtgca
218041 cgccagtttc agcgttacca acacgggcga ccgcagcggg gcggatgtcc cgcagctgta
218101 tatgatcgca gctcccggcg aatcgcggtt gcggttgctg ggattcgagc gggtcgagct
218161 cgaacccggc cagactcggc gggtaaggat cgaggcggac ccgcgactgc tcgcccgcta
218221 cgacggcgag gccagaagct ggcgcatcga gccgggcggt tacacggtgg cggtgggcgc
218281 ttcggcggta gcgctgaagc tggcagccaa ggtcaagctg gccggccgtg ggttcgggcg
218341 gtgacgggcc ggcccagcga ggcccgtacc cacgaccggc atgataggtc tacttgaccg
218401 gggccaattc gtcgccgcag gtgcagcggt aggcgtcacc ggcgccagca cagtggcatg
218461 ggacttcgat gcgaacccga cagccacagc cctcgtggct gcaggtcagc aaggtcccag
218521 cctcgtagtt cgtcattcgt atcaccctca tccgtgtcgg ggatccccga ggaatcccag
218581 gtggtcagct gtcggtaatc cagaacagct acttaaatat ataccctata cgggtatctg
218641 gtaaaccccc aggccggtgg gcggttgcct gctggcgcgc gacggtcggt ggtcgcgcta
218701 gcgtttgggc atggaccagc aacccaaccc gcccgacgtc gacgcatttt tggacagcac
218761 actggtcggc gacgatccgg cgttagccgc ggcattggcg gccagcgacg cggccgagtt
218821 accccgcatc gcggtgtcgg cacagcaggg caagttcctg tgcctgctgg ccggtgccat
218881 ccaggcgcgc cgcgtcctcg agatcggcac actcggtggc ttcagcacca tttggctggc
218941 gcgtggcgcg ggcccacagg gacgggtggt cacgctggaa taccagccca agcacgctga
219001 ggtcgcccgg gtgaacctgc agcgagcggg cgtcgccgat cgggtggagg tggtcgtcgg
219061 tccggcgctg gacacgttgc cgacgttggc cggtggcccg ttcgacctgg tgttcatcga
219121 cgccgacaaa gagaacaacg tcgcatatat tcagtgggcg atccggttgg cccggcgcgg
219181 cgcagtgatc gtggtggaca acgttattcg tggcggcggg attcttgctg agtccgacga
219241 tgccgacgca gtggcggcac gtcggacgct gcaaatgatg ggtgagcacc ccggcctaga
219301 cgccacggcg atccagaccg tcgggcgcaa gggctgggac ggtttcgccc tcgctttggt
219361 gcggtagccg ctggtccggc gcccaatttt cgttgctggc atcccgaaaa cgggcgtaat
219421 cttggagcag atggatgggt ggcagcgagc ccaaaagttt tgctgcataa cagaaaggtt
219481 gcaaaatgag tacagtccat tcatcaattg atcaacaccc tgatttgttg gctctgcgtg
219541 ccagcttcga ccgcgccgcc gagtcgacga tcgcgcattt cacattcggt ctggccctgc
219601 tggcgggcct gtatgtggct gcatcgccgt ggatcgtcgg cttcagcgcc accagagggc
219661 tgccaacgtg tgaccttatc gtggggatcg cggtcgcgta cttggcgtat gggttcgcgt
219721 cggccctgga tcgcacacac ggcatgacct ggacgctacc cgtgctcggt gtgtgggtca
219781 ttttctcgcc gtgggtgcta ccaggggtcg cggtgacggc tggcatgatg tggtcgcaca
219841 tcatcgcagg tgcggtggta gccgtcctgg gcttctactt cgggatgcgc acgcgggccg
219901 cggctaacca aggatagttc gaagttcgcg agccagaggg caactcggga atgtcctggc
219961 cggggcggtc ccggccaggc agcggctagt tgcggctagc cgcagaccgc gccgaccgcg
220021 gcagagctga ccagcttgac gtacttggac agtacgccag tagtgtagcg cggcggtgga
220081 ggactgaaat cctgttgtcg ggacgcgaat tcggccggat cggccaacac atcgagaacg
220141 cggccggcca cgtcgagccg gatccggtcg ccgttgcgca gaagtgcgat cggtccgccg
220201 tcgaccgcct ccggtgcgat gtggccaacg cacaggccgg tggttccacc ggagaaccgg
220261 ccgtcggtca gcagtagaac atctttaccg agtcctgcgc ctttgatcgc gcctgtgatg
220321 gcgagcattt cgcgcatccc ggggccgccc ttgggtcctt cgtaccggat taccacggcg
220381 tcgcccacgg taatggtgcc atcctcaagg gcgtccagcg cagcgcgctc gccgtcgaaa
220441 actcttgcgg tgccttcgaa tacgtcggaa tcgaatccgg cggtcttgac caccgcacct
220501 tcgggtgcca gcgatccgtg caggatggtg atgccaccgc tcgggtggat cgggtttgcc
220561 aacgcacgta gcaccttgcc atctggatcc ggcggggtga tggcagccag attctcggcc
220621 atggtgtgac cggtaaccgt caggcagtcg ccgtgtagca gaccggcgtc cagcagcgcc
220681 ttcataacca ccggcacacc gccgatgtga tcgacgtcgg acatcacatg gcggccgaac
220741 ggcttgacat cggccaaatg cggcaccccc gacccgatcc ggctgaagtc ctgaagcgat
220801 agtgcgacgt tggcctcgtg ggcgatggcc agcagatgca gcaccgcgtt ggtcgagccg
220861 ccgaacgcca ttaccaccgc gatggcgttc tcgaacgcct ccttggtgag gatgtcgcgg
220921 gcggtgatgc cgcggcgcag cagctcgacg acggcctgac cgctgcgacg cgcgaacccg
220981 tcgcgccggc ggtcggtcgc cggcggtgcc gcgctgcccg gcaacgacat gccgagcgcc
221041 tcggcggcgc tggccatggt gttagcggtg tacatgccgc cgcatgcccc ttcgccgggg
221101 cagattgccc gctcgatggc atcgacgtcg gcgcgactca tcaaaccgcg agagcacgct
221161 ccgaccgcct cgaaggcgtc aatgatggtg acgtctcgtt cgctaccgtc ggagagcttg
221221 gcccggccgg gcaaaataga gcccgcgtag aggaacaccg ccgccagatc cagtcgtgcg
221281 gcggccatca gcattccggg cagcgatttg tcgcatccgg ccagcagcac cgaaccgtcg
221341 agtcgttcgg cctgcatcac gacttcgacg ctgtcggcga tcacctcacg ggaaaccagc
221401 gagaagtgca tcccctcatg acccatggag atgccgtccg aaaccgagat cgtgccgaac
221461 tcaagcggat agccgccggc cgaaaacacc ccctccttga ccgcgttggc cagccggtcc
221521 aatgagagat tgcacggcgt gatttcgttc cacgacgacg cgaccccgat ctgtggcttc
221581 gcgaagtctt cgtcgtccat gcccaccgcc ctcaacatgc cccgggcagc ggccttctcc
221641 aggccgtcgg tgacgtctcg actgcggggc ttgatgtcgg cgaccgtcga gacggaagcg
221701 gcttcgtcgg tggtttgcgg cattgttcaa gtatgcggcc caaggatgcg ctcgccgcgg
221761 cacggttgcc aaattctagg tccgataccc cgctggggta caagatatga tgggtagcat
221821 gcctgggccc tgctttcggg ttggcgagta tctctggaga tggcgagtaa atgacagcag
221881 cacacggcta cacgcagcaa aaggacaact acgccaagcg gttgcgtcgc gtcgaggggc
221941 aagtgcgcgg catcgcgcga atgatcgagg aagacaagta ctgcattgac gttctgaccc
222001 agatcagcgc cgtcaccagt gcgttgcggt cggtggcgct gaacctgctg gacgagcacc
222061 tgagccactg cgtcacccgt gccgtggccg agggcggtcc tggggctgac ggcaagctgg
222121 cagaggcctc ggcagcaatc gcgcgcctgg ttcgttcctg atcgccgcgt gttgaagcgc
222181 aaacctgccc accacccgtt ggtgcggtgc gtacggtagg ggcagcgtaa tcgtgccctg
222241 aacgaccccg aaccatcgaa cttcgcggcc gattccgcgc aggacgcgat gactgcccca
222301 accggaacct ccgccactac gacgcgaccg tggacgccac ggatcgccac gcaactgtcc
222361 gtgctggctt gcgcggcctt tatctatgtc accgccgaaa tcctgccagt gggcgcgctg
222421 tcggcgatag cgcggaactt gcgcgtcagc gtggtcctag ttgggacctt gctgtcctgg
222481 tatgcccttg tcgcggccgt gacaacggtt ccgctggtgc gttggaccgc acactggccg
222541 cgccgccggg ccctggtggt cagcctggtc tgcctgaccg tctcgcaact cgtctcggcg
222601 ctggcgccca acttcgcggt gctggccgcc gggcgggtgc tctgcgcggt cacccatggc
222661 ctgctgtggg cggtcatcgc gccgatcgcc acccggctgg tgccgcccag tcacgccggg
222721 cgcgccacga cgtcgatcta catcggaacc agtctggcgc tggtcgtcgg tagcccactc
222781 acggctgcca tgagcctgat gtggggttgg cggctggcgg cggtgtgcgt gaccggcgcg
222841 gcggccgcgg tcgccctggc cgcccggctg gcgttgccgg agatggtgct gcgcgccgac
222901 cagctcgagc acgttggccg acgggctcgt caccaccgta atcctcgcct ggtcaaggtc
222961 agtgtgctca cgatgatcgc ggtaaccggc catttcgtgt cctacaccta catcgtggtg
223021 atcatccgcg acgtcgtcgg tgtacgtggg ccgaatctgg cctggctgct cgccgcctat
223081 ggggtcgccg gcctggtgtc cgtgcccctg gtggcgcggc cgttggaccg ttggcccaag
223141 ggcgccgtca tcgtcggtat gaccggactg acggcggcgt tcaccttgct gaccgcgctg
223201 gcattcggtg aacgccacac cgcggcgacg gcactgctgg gcaccggtgc gattgtgctg
223261 tggggagcct tggccactgc cgtgtcaccg atgctgcaat cggcggcgat gcgtagcggc
223321 ggcgacgacc ccgacggggc ctcaggtttg tatgtgacgg cgtttcagat cggcatcatg
223381 gccggcgctc tgctgggtgg gctgctctac gagcgcagct tggcgatgat gctgaccgcg
223441 tcggcgggtt tgatgggtgt tgcgttgttc gggatgacgg ttagccagca cttgttcgag
223501 aatccgactc tgagtcccgg cgacggctaa cacagcaggt cagcgggacc agttggtgcc
223561 gctatgccac actgggctga agaacgtcac cggagggaaa gcaattatgt cgcgctggaa
223621 gcagggctgg acgaggggga gtctattcgc cgctctgaac atagccgcag tggttgcggt
223681 gctgatgctg ggtgctggcg ttgccgtggc ggacccggac gcggctcccg gcgatcccgg
223741 aggtcccggg gccccggggg cacagcggga cccgtcgacc cgccggcagt tgacctgttg
223801 gcgccgccac ccgacccgtt ggcgctgccg ccggcacttg acccgttggc gccgccgcca
223861 cctgacccgc tcgcgccgcc cccgcctgac ccgctggcag tgccggtagc agcgggcccc
223921 gttgccgggc aggatccgac atcgtttgtt ggcccgccgc cgttccggcc gccgacgttc
223981 aatccggtcg acggcgcgat ggtcggtgtg gccaagccga tcgtcatcaa cttcgcggtg
224041 ccgatcgccg accgggcgat ggccgaaagc gccatccaca tttcgtccat cccgcccgtg
224101 ccgggcaagt tctactggat gagcccgact caggtacgct ggcgcccgtt tgagttctgg
224161 cccgccaaca ccgcggtaaa catcgatgcg gccggcacca agtcgagctt ccggaccggt
224221 gattcgctgg tggccaccgc cgacgacgcc acgcatcaga tgacaatcac ccgcaacggc
224281 gtcgtgcaaa agaccttccc catgtcgatg ggcatggtgt ccggcggcca ccagaccccg
224341 aatggcacct actacgtgct tgagaagttc gccaccgtgg tcatggactc ctcgacgtac
224401 ggggtcccgg tcaactcggc ccaaggctac aagttgaccg tctccgacgc cgtccggatc
224461 gacaacagcg gcaacttcgt gcacagcgcg ccgtggtcgg tggcagatca gggcaagcgc
224521 aacgtcaccc acggctgcat caacctcagc ccggccaacg cgaagtggtt ctacgacaac
224581 ttcggcagcg gtgacccggt cgtcgtgaag aactctgtcg ggacttacaa caaaaacgac
224641 ggtgcccagg actggcagat ctaacggccg cgcggttgcc cacgagtgac ccgtagccaa
224701 tcgcggctcc ccttactgga gctttactga aagcaggtca gcgacagcat cgtgtagtgc
224761 cgaagcagcc ggcgggcgca gtctttcacc accaggttgc gcctgccgtc gagactgtag
224821 gcggcgtcga ccgcccagaa ggcgaacaag ctggtcgata ggtaagcggc catgtcctcg
224881 cagcgcagca gtgcctcggc cacatcctcg agcaggtgtt tgaccgagcg cgcggcctcg
224941 gcatggctca tgccgagcaa gtcgaagtgc caatcggcgg gcgggtcttg gtcttcgtcc
225001 agcggcagcg tctttagcac ctcggagatt agcgcgtgga tctgcagcgg acgtagacag
225061 tcggccgggc ggggctgctg aatgtcggca agccagccca gcaaccgctc gtatagccga
225121 tctgctgaca tctcgcgaat caggttgcgc gcccacttcc gcggttcctc gcggttgtcg
225181 tggtaaagga tcagatccag cgggccatgc ttgtcgaacc gcatcaggcg ccagatcagg
225241 tcgaagaact cctccgctga caggacctca ccgtagggaa tcgtcagttc gcggttgcgg
225301 atctcgcgca cttcgggggc cttggtggcc gccgaaatcc attcctcgaa ccgcgcgccg
225361 tcgatctgct ttgtctgcag tggtagcgat accggacgtt gcggggtttt cttccacttg
225421 aggagcagtt cggcaatctc gtcagcggcg gcgcacaggg tggcaataaa tcgctgctgg
225481 taagactcgt cgggtacacc cctagtcaac agctcgctca aggagacatc cgaactgtcc
225541 tcgacatcgc tgaccatccg ccctggattg tcggcgacgc ggtggaaaac cagaatgatg
225601 cagctgcgag cacttccgga ggcggtgcgg aagcggtgat gcaccagcga gccagcggcg
225661 aatacaccgc tcagcggtcg ctcggaatcg gtcacctcga tcaccgttgg gtggtcctga
225721 ccgcccagct ggcgctgcgc gtcgaacacc ttgcggatgc tgtcgggggt ggtgaagatc
225781 gatgcatttt cactcgacca cggcaccccg tcctcgttga cgaagcaggt gcgggcgagt
225841 ttatgggtgc cgggtaggaa ggtgaaattc tgtcccgctg gcccctgcgc ggttccgcgc
225901 cgccaggtaa tgaggatctt gtattcgtcg ttgaacgggg tgttgtcgat atgcagcatg
225961 ttgtcctggg ccaggaccga cagcggttcg gcgtccttgc cgcgtgcatc gatcattctg
226021 atcggtccac cgacggcata ggagatcaac gcgatcatca aggggtgcac cagcgcgcca
226081 ttgaccgctg gatcggtcag cattccgggg cttcgccgca ggtctaggaa gcggtgaatg
226141 aaactgcgac tgccctcccg ggccatgagt tcgtcgtagc gttttaccaa ttccaaaaag
226201 tcgtccgact cgacgatgtc ggcaaggacg actgcgccct gctcggccat ctgatcgatg
226261 aggtctcgta gtgccgcggt ggcgatttcg gcagcttctg aaccctgggc cgccagcgcg
226321 tcggtcagct cctgcagcag tttcctgcgg taggactcct tgtcatctag atcacggaat
226381 cgtttgtagg cccaggcggc gggcagctgg tcctgtgaca ccagctcggg accgatcggt
226441 ggtgcgtatt ccagcggcaa tatgtcatcg gcggcgaact tggtcagctg gattccgtcg
226501 gaattatccg gcaaggcctg ggtggtcgca gtctgaccga gtgagctcat gtcccgggaa
226561 atctgaatca cctccgcttt cgcgtattgc gcaagaactc ggttcgttga cccgtcgagg
226621 tcgactgcag aacgtacctc cggaggcggc gttatcgcca gacctattac ctgggggtct
226681 gcccgaaagg gaaaacccgg tgtcctttct ggttatcgaa gtgaccggaa tattcggtgc
226741 cggcggcgca cacgcgagaa tggatgccgc gcacgagttt atgcgcttgt tcgggttctg
226801 cccgaaaggg aagacttgat ttcccgttag ttcaaccacc gggtgatcgg cgcactgaac
226861 gagaaaggat atggcgaatg cgcacgaatt gctggtggcg gttgtccggc tatgtcatgc
226921 ggcatcggcg cgatctgctg ttgggattcg gggcggcgct ggccggcacc gtcatcgccg
226981 ttttggttcc gctggtaacc aagcgtgtca tagacgacgc gatcgcggcc gaccacagac
227041 cgctggcgcc ctgggccgtg gttctggtcg ccgccgccgg ggcgacctac ttgctgatgt
227101 acgtacgccg gtactacggc ggtcgaattg cccacctggt acagcatgac ctgcgcatgg
227161 acgcctttca ggccctgttg cggtgggacg gccgacaaca ggaccggtgg agcagcggcc
227221 agctcatcgt ccgcaccacc aatgacctgc aactggtgca ggcgttgctg ttcgatgtgc
227281 ccaatgtgct caggcatgtg ctgacactgc tactaggtgt cgcggtcatg acctggttgt
227341 cggtgccgct tgcgctgctt gcggtgctgc tggtacccgt gattggcctg atcgcccacc
227401 gcagccgccg gctgctggcc gcagccaccc actgtgccca ggaacacaag gccgcggtca
227461 ccggagtcgt cgatgcggcg gtctgcggaa tccgggtcgt caaggcgttc gggcaggagg
227521 agcgggagac ggtcaagctg gtgacggcat cccgcgcgct ctatgctgcc cagctgcggg
227581 tggccaggct caacgcacac ttcggtccgc tgctgcaaac cctgcccgcg ttgggtcaga
227641 tggcggtctt cgcgctcggc ggatggatgg ccgcgcaggg cagcattacg gtgggcacct
227701 ttgttgcctt ctgggcctgc ctgacattgc tggcgcggcc ggcatgcgat ctggcgggga
227761 tgctgaccat tgcccagcag gcgcgcgccg gcgcggtgcg ggtactcgaa ctcatcgaca
227821 gccggccgac gctggttgac ggcaccaagc cgctgtcgcc ggaggctcgg ttatcactgg
227881 agttccagcg ggtgtccttc ggatatgtgg ctgaccgccc cgtgctccgc gagataagcc
227941 tgtcggtccg ggccggggag accctggcgg tggtcggtgc gccgggcagc ggcaaatcca
228001 cgttggcgtc gctggcgacg cgttgctacg acgtcacaca gggcgcggtg cggatcggtg
228061 gtcaggatgt gcgcgagctg acgctcgact cgctgcggtc agccatcggc ctggtacccg
228121 aagatgccgt cctgttctcc ggaacgatcg gtgcaaacat cgcctatggc cgcccggatg
228181 cgacgcccga acagattgcc acggcggccc gggcggcgca catcgaggag ttcgtcaaca
228241 ctctgccgga cgggtatcag acggccgtcg gtgcgcgcgg actgacgctg tccggcgggc
228301 aacgccaacg catcgccctg gcccgggcgc tactgcacca gccgcggttg ttgatcatgg
228361 acgacccgac ctctgccgtg gatgcggtca tcgaatgcgg aattcaggag gtgctgcggg
228421 aggcgatcgc ggatcgcacc gcggtcattt tcacccgccg ccgatccatg cttaccttgg
228481 ccgaccgggt cgcggtcctc gactccgggc gcctgctcga tgtcggcacc cccgacgagg
228541 tgtgggagcg ctgtccccgc tatcgggaat tgctgtcgcc cgcgccggat ctcgccgatg
228601 acctggttgt cgcggagcgc tcgccggtgt gtcgaccggt ggccgggctc ggcaccaagg
228661 ccgcgcagca caccaacgtc cacaaccccg ggcctcacga tcacccaccc ggccccgacc
228721 cgttacgccg cctgctgcgt gagttccgcg gcccgcttgc gttgagcctg ctgttggtgg
228781 ccgtgcagac ctgcgcgggt ctgctgccgc ccctgctcat ccgccacggt attgacgtcg
228841 ggattcgccg ccatgtgctc tcggcgcttt ggtgggcagc gctcgccggc accgccaccg
228901 tggtcattag gtgggtcgtg cagtggggga gtgccatggt cgccggatac accggtgagc
228961 aggtgctgtt tcgattgcgg tccgtcgtct tcgcccatgc ccagcgcctg ggcctggacg
229021 catttgaaga cgacggagat gcccagatcg tcaccgcggt caccgccgac gtcgaggcca
229081 tcgtggcgtt cctgcgcacg ggtctggtcg ttgccgtgat cagcgtggtg accctggtcg
229141 gcattttggt ggcgctgctg gccatccgcg cccggctggt gttgctgatc ttcaccacca
229201 tgccggtgct tgcccttgcg acctggcaat tccgtcgggc gtcgaattgg acctatcggc
229261 gggcgcggca ccggttgggg acggtaaccg ccacgttgcg tgagtacgcg gcggggttgc
229321 ggatcgccca ggcgttccgc gccgaatacc ggggactgca aagctatttc gctcatagtg
229381 acgactatcg ccgacttggg gtgcgcgggc agcggctgct agccctgtac tacccgttcg
229441 tggcattgct ctgcagcctg gcgaccaccc tggtcctgct cgacggtgca cgcgaggtgc
229501 gagcgggggt gatctcggtc ggagcgctgg tgacctatct gctctacatc gagctgttgt
229561 acacgccgat aggcgaactg gcgcaaatgt tcgacgatta ccagcgtgcg gcggtggcgg
229621 ccgggcggat ccggtcgctg ctgagcacgc ggacaccgtc gtcgccggcg gcacgaccgg
229681 tggggacgtt gcgtggtgaa gtggttttcg acgccgtcca ctattcctac cgaacacgag
229741 aagtgccggc actggccggc atcaacctgc gaattccggc cgggcagacg gtggtgttcg
229801 tcggctccac cggatccggg aaatccaccc tgatcaagtt ggtggcgcgg ttctacgatc
229861 cgacccatgg gacggtccga gtcgacggat gcgacctgcg ggagttcgat gtcgacggct
229921 atcgcaaccg gctcggcatc gtgacgcagg agcagtacgt cttcgccggg acggtccgcg
229981 atgccatcgc atacggacgg cccgatgcca ccgatgccca ggtcgaacgg gctgcgcggg
230041 aggtcggtgc ccatccgatg atcaccgcac tcgacaacgg gtacctgcat caggtcaccg
230101 cgggtgggcg caatctgtcc gccggtcagc tgcagttgct cgcattggcc agggcgcgtc
230161 tggttgaccc cgacattctg ctgctggatg aggccaccgt ggccctggat cctgccaccg
230221 aggccgtggt gcagcgggcc accctcaccc tggcagcccg tcggacgacc ttgatcgtgg
230281 ctcacgggct agccatcgcc gaacacgccg accgcattgt cgtgctcgag cacggcaccg
230341 ttgtcgagga cggcgcccac accgaacttc tcgctgctgg gggccactat tcgcggctgt
230401 gggcggccca tactcgactg tgttcgccgg aaatcactca gcttcaatgt attgacgcat
230461 agacgtcacc aagccaccga atgggtggcg agttgaccgg gcgccggatc ccgacggttg
230521 tggttgatct gccgaatcaa cggcttctgg ccacgaacat gtgtccgcga ctggcgtctg
230581 cgataccaac ccaatcggtt actatagaaa ctgttcccgc cgacaactaa ctcccttgtt
230641 cgcgtggagg ggttctcggg tccggtcagc gaggtccgga gcggggcgga aatttcattg
230701 aacagccgta gaagttcagc caggaccgga acggatccag cggcaagcat gccttcagga
230761 gccatgttgt cgaatcagtg cctagggctg ggggcgcccg gaaggaacac cacagggggg
230821 accgacattc cgcatgtggt caagcgcagc ggagcgaaat tccgcgagga gttcatcctc
230881 cgtccggacc gggtgcaaat ggcaccggtg aatgtcattt cggtcgcggt ggtggcgagc
230941 gacccgttga cccgcgatgg agctttggcc cgactctcgt ctcaccggga gctcgacgtg
231001 cgcgcttggc aggctggatg cgaaacctcg gtcctgctcg tgctggccac cacgatcacc
231061 gcgcctcttc tatgccagat cgaggacgtg cagaaggatg gccccagtca cgccccgaaa
231121 ctggtcgtcg tcgccgacga attctccgct gaacaagttt tccggatgat caagctgggg
231181 ttgaccgggt tgttgtatcg cagccagagc acgttcgact gcatcgtcga gacaatccgg
231241 ttgtccgccg aaggccgcct gcgactcccc gaacgtgtcc agcgttacct ggtcggccgc
231301 atcaagtcca ccccgaccgc cgaacctgac acaccgtgcg ccgccgctct tgccgagcgt
231361 gaggtggcgg tgctgcgtct gctagcggac ggcttgagca cgcaccaagt ggcggtgcag
231421 ctcaactatt gcgagcgcac gatcaagaac atcgttcatg acatagtgac gcggctgaag
231481 ctccgcaacc gcacgcatgc cgtcgcacat gcgctgcgcg cgggcctcat ttgattgatg
231541 gccggcgtcc gacgtacgtg cggccgggcc gatcccaagc gagtggtgta acgtgcacgg
231601 tagccattat gtatagcaac atacatatgc ctcggatgga gcggcgatgc aaggtccacg
231661 cgaacggatg gtggtctcgg ccgcgctgtt gattcgggaa cggggagccc acgccaccgc
231721 catctcggat gtgctgcagc acagcggcgc accgcggggg tcggcctatc actacttccc
231781 gggcggtcgt acccaactgc tatgcgaggc cgtcgattac gccggagagc atgtcgccgc
231841 catgatcaac gaggccgagg ggggcctgga gctgctggac gcgctgattg acaagtatcg
231901 ccagcagctg ctcagcaccg actttcgcgc cggctgcccg atcgccgcgg tctcggtgga
231961 ggcgggcgac gaacaagatc gcgagcggat ggccccggtg atcgcgcgtg cagcggcggt
232021 gtttgaccgc tggtcggact tgactgccca gcggttcatt gccgacggca taccgccgga
232081 tcgggcgcac gagctggcgg tgttggcgac gtcgacgctc gagggcgcaa tcttgctggc
232141 tcgggtgcgg cgcgacctga cgccgctgga tctggttcac cgccagctgc gcaacctgct
232201 gctggccgag ctgcccgaaa ggagccgatg atgaccagct ctgattggct gcccaccgcg
232261 tgcatcctct gcgagtgcaa ctgcggcatc gtcgtgcaag tcgacgatcg ccgactggcc
232321 cgcatccggg gcgacaaggc gcatccgggg tctgcgggct acacctgcaa caaggcgttg
232381 cggctggacc attaccagaa caaccgggct cgcctgagct cgccgatgcg ccgccgagcc
232441 gatggcacct acgaggagat cgactgggac acggcgattg tcgagattgc cgagggattc
232501 aaacagatcc gtgataccca cggcggggac aagatcttct actacggcgg cggcggacag
232561 ggcaatcacc tcggcggcgc ctacagcggc gcctttctga aggcactggg gtcgcgctac
232621 cggtcgaatg cgctggcgca ggagaagacc ggcgaagcct gggtcgactt ccagctgtac
232681 ggcggtcaca cgcgcggcga gttcgagaac gccgaggtgt cggtgttcgt cgggaagaac
232741 ccatggatgt cgcagagctt cccgcgggcc cgggtcgtgc tcaacgagat cgccaaggat
232801 cccggccggt cgatgatcgt gatcgatccc gtcgtcaccg acaccgcgaa gatggccgac
232861 ttccatctac gggtgcaacc gggttgcgac gcctggtgct tggcggcttt ggccgcggtc
232921 ttggtccagg aaaacctctg taacgaagcc tttcttgccg cgcacgtgca cggagtggac
232981 accgtgcgcg ccgccctgca agaggtcccg gtcgccgact acgcgcagcg ttgcggggtg
233041 gacgaggagt tgttgcgtgc cgcggcccgg cgcatcggca ccgccgcgag cgtgtcggtg
233101 ttcgaagacc tgggaatcca gcaggcgccc aacagcaccg tctgctccta tctgaacaag
233161 ctgctgtgga tcctgaccgg caacttcgcg aaaaagggtg gccaacacct gcattcgtcg
233221 ttcgctccgc tgttcagcca ggtctccggc cgcacaccgg tcaccggtgc gcctattatc
233281 gcgggcctga tcccgggcaa cgtggtgccc gaggagatcc tgaccgagca cccggatcgg
233341 tttcgggcga tgatcgtaga gaggggcaat ccggctcact cgctggccga ttcagccgcc
233401 tgccgggcgg cattccaggc gctggaactg atggtggtcg tcgatgtcgc catgaccgag
233461 acggccaggc tcgcccacta cgtgctgccg gcggcgtcgc agttcgagaa gccggaagcc
233521 acattcttca atttcgagtt tccacgcaac ggctttcagt tgcgccggcc gttgtttccg
233581 ccactgcccg gaacactgcc cgaacccgag atttgggcgc ggctggtgcg ggcacttggc
233641 gtagtcgacg aagcggacct gcggccgctg cgagaggccg ctgctcaggg tcgccaggcg
233701 tataccgagg cgttcctcgc ggcggcggcg accaatccca ccgtggcgaa actgaccgcc
233761 tatgtgctct atgaaacgct cgggccgacg ctgccggacg gtctggccgg ggcggccgcg
233821 ttgtggggac ttgcccagaa gacggcgatg gcctaccctg acgccgtccg ccgcgccggc
233881 cacgccgacg gcaacgcgct gttcgacgcg attctcgagc gcccctccgg ggtcacgttt
233941 accgtgcaca actacgaaga cgacttcgct ttgattagcc accccgatca caagatcgcc
234001 ctggagattc cggaaatgct ggcagagatc cggtcgctga cccagacccc gtcgcggttg
234061 accacgcctc aactgccgat cgtgctgtcg gtgggcgagc gccgcgcgta cacggccaac
234121 gacatcttcc gtgacccgtc ctggcgcaaa cgcgacgcca acggggcgct gcgggtcagc
234181 gtcgaagacg cccaggccct gggactggcc gatgggtgcc tggctcgtat cacgaccgcg
234241 gcgggcagtg cggaggcgac ggtggaggtc accgagacga tgctggccgg acacgccgcg
234301 ctgcccaacg gctttgggct ggactacacc ggcgacgacg ggcgcaccgt cgtcgccggt
234361 gtcgccccga acgcacttac ttcgacgaga tggcgcgacc cctacgccgg caccccctgg
234421 cacaagcacg tgcccgccgc catccgccga gcagacgcag aatcgcccat ttggtatccc
234481 aaatgggcga ttctgcctgc tcgcggggtc ttagcctagt tccagatccg gaccctgcgc
234541 tgcgggtcca gaaacagcgc gtcatcctcg gtgacgtcga aggcctgata aaaagcgtcc
234601 acgttgcgaa ccacaccgtt gcaccggaac tccggcgggg agtgcggatc gaccgccaac
234661 cggcggattg cttcggctgc acgcgatttg gttcgccata tttgtgccca gccgaagaac
234721 acccgttgca tgccggtcag cccgtcgata accggagcgg ggttgccgtt cagcgagagc
234781 tggtaagcca gcagggcgat cgacagcccg cccaggtcgc cgatgttctc gcctatggtg
234841 aacgcgcctt gcacatgagg cgggccgggg tggtcgacga gatcgcgcgg cgtgtaagcg
234901 tggtactgct cgatcaacgc tttggtgcgg gcggcgaact cggtgcgatc gtcgtcggtc
234961 caccaatcga ccagattgcc gtcgccgtcg tatttggcgc cctgatcgtc gaaaccgtgc
235021 ccgatctcgt gcccgatcac cgccccgatc ccgccgtagt tggcggcctc gtcggcctgc
235081 ggatcgaaaa atggtggctg taaaatcgct gcggggaaga cgatttcgtt catccccggg
235141 ttgtagtagg cgttgacggt ttgtggtgtc atgaaccact cgtcgcggtc gaccgggccg
235201 aaaagcttgg ctagctcgcg gtcatggttg acggcgtagc cgcgctggac gttaccgtag
235261 aggtcgtcgc ggtcgatcgc cagcttcgag tagtcgcgcc acttgatcgg atagccgact
235321 ttggcggtga acttgttcag cttcgctagc gcgcgttgcc gggtctgcgg cgtcatccaa
235381 tccagctcgc tgatgctgat ccgatacgcc tcctgcaggt tgtccaccag ggtgtcgatg
235441 cgggacttgg catccggcgg gaaatggcgt tgtacataga gctttccgac ggcatcgccc
235501 atcaggttct ccaccagtga caccccacgc ttccaacggt cccgaagctg ctgtgcgccg
235561 gtaagcgtgc ggccgtagaa ttcgaagtcc tcggcgacca gggcgcgggt cagccagggg
235621 gcccgggcgc ggatcaaacg ccaacgcgcc cagcatttcc agtcttcaac gttaacgctc
235681 gcccacagcg aggcaaaggt gacgaggtaa tcaggttggc gcacaaccag ttccgtcatg
235741 gcgtccggag cgctccccaa tgcggtcacc cagctgaccc agtcgaaacc cgccccttcg
235801 gtctgcagct gggcaaacgt gcgcaggttg tagccaaggt cggcgtcgcg gcgcttcacc
235861 acatcccaat gcgcgtcggc gagtttggtc tccagcgcga cgatgcggtc cgcggttttg
235921 gcatggtcac ggctctcgcc cccgtacacc aggccgaaca tccgggcgat gtgccccggg
235981 taggccgcta gcacggcggc gtgttgctcg tcacggtagt aggactcgtc gggtaatccg
236041 atgccggatt gggtgaaatg caccaagtaa cgggtcgagt ctttggaatc ggtatcgaca
236101 tagactccga tgccgccgcc cacgccggca cgttgcagag tgccaagggc ggcggccaat
236161 tcggtggcgt cggccgcgct gtcaatcgtg gccaattcgt cgtgcagcgg ttgcacccct
236221 gcgcgctcga cggcttcctc gtcgaggaag ctggcgtaga ggtcgccgat gcgctgcgca
236281 tcggtgccta ccgcagcacc tgcttggctg gcctggatga tcaggtctcg cacttgtgtc
236341 tcggcgcggt cgaacaggct acggaaggcg ccgtcggtcg ctcggtccgc tggtatctcg
236401 tgttcagcca gccagcggcc gttaacgtgg ccgaacaggt cgtcttgggg tcgggcatca
236461 gcgtcgatgt ggctcaggtc gatacccgag gggatggcaa gtgtcacccc gccatccttc
236521 cacctctttt cgggtgcaac gatcgggcca tgcctgacgg ggagcagagc cagccaccgg
236581 cccaagaaga tgcggaagac gactcgcggc ccgacgccgc ggaggccgcc gcggccgaac
236641 ccaaatcatc agccggtccg atgttctcga cctacggtat cgcctcgaca ctactcggcg
236701 tgctatcggt cgccgcggtc gtgctgggtg cgatgatctg gtccgcacac cgcgatgact
236761 ccggcgagcg tacctacctg acccgggtca tgctgaccgc cgctgaatgg acggccgtgc
236821 tgatcaacat gaacgccgac aacatcgatg ccagcctgca gcgactgcac gacggaacgg
236881 tcggtcaact caacaccgac ttcgacgctg tcgtgcagcc ctaccggcag gtggtggaga
236941 agttgcggac gcacagcagc ggcaggatcg aggcggtagc gatcgatacg gtgcaccgcg
237001 agctggatac ccagtccggt gccgcccgac cggtagtaac cacgaaattg ccaccgtttg
237061 ccactcgcac cgactcggtg ctgctggtcg cgacgtcggt cagtgagaac gccggcgcca
237121 aaccccagac cgtgcactgg aacttgcggc tcgatgtctc cgatgtggac ggcaagctga
237181 tgatctcccg gttggagtcg attcgatgag aaatgcttgg cggctggtgg tgttcgatgt
237241 cctggcacca ctggccacga tcgccgccct ggccgcgatc ggcgtcttgc tcggctggcc
237301 cctgtggtgg gtttcgacgt gctcggtgtt ggtgctgctg gtggtcgaag gtgtggcaat
237361 caacttctgg ctgttgcgtc gtgattcggt aaccgtcggt accgacgacg atgcgcccgg
237421 gctgcgactg gccgttgtct tcctgtgcgc cgccgcgatc tcggcggcgg tggtgactgg
237481 gtacctgcgc tggacgacac cggaccgcga cttcaatcgg gattcccggg aagtggtgca
237541 tcttgccacg gggatggccg agacggtcgc gtcattctcc ccgagcgcac cggccgccgc
237601 tgttgaccgg gccgcggcga tgatggtgcc cgaacatgcg ggcgggttca aggagcaata
237661 cgccaagtcc agcgccgatc tcgcacggcg cggtgttacg gcccaggccg ctacgctggc
237721 ggccggcgtg gaggcgatcg ggccgtcggc agccagtgtt gcggtgattc tgcgggttag
237781 ccaaagcatt cccggccagc cgaccagtca agcggcgcga gcgctgcggg tgaccttgac
237841 caagcggggc agcggctggc tggtgctcga cgtgacgccg atcaacgctc gctaagagtc
237901 ggcggcacgt acggatttgg ctctgacgaa ccggtccgac agccgccgca tccggatcat
237961 cagcgaggcc gacgggctca cgatgccgtc gaggtaggcg gtcaggtcct gcgctgtgac
238021 gccaatgcgc gacgcgaatt cctgtcgttg caggccagag cggtccaaca ggagcccaac
238081 ctgacgggcc acctcggcgc gctcattggc gtctaggtga gtacgggccc ggtccagcac
238141 ctcccaaaag gcgttggcga tgccggtcgc cggtatgccc tcgaggactt cttcgacttg
238201 gcgtgctgtc cgcccgtagg ggtcgcgctt gagcgcggcc gctatgcgtt gccaggtggc
238261 gatgtcgcca ctttccagcg ccgaacgaat ggcgacggta ggccagaact cgacccgccg
238321 gtcgacgtcc ggctcgctcc acgcgacggt gggttgttgc ggcggtgcgg ggtgtggctc
238381 ggctgccaac gtcacctcgc ctcctccaac atcgccacgg ccaccgacag gcaacgccgc
238441 cggacctctt cccactttgc ctgggcatca gctccgggcg actggtcacc gaggtcagac
238501 ggttgcggat ctgccaggcg accaaccaac tgggtggcca tccattgccg cccgggtgct
238561 tgacaagagt agtaccgatc catcccagcc agcaccgcgg cggcggtttc gggtgccatc
238621 gtatcgacca ggtcagcaaa gtcggcgtag tcgtggctgc tgtttcggga catgatcagg
238681 tagcccttga agcgcagcgt ttccgcgccg gttgggatct gcaagcggtc accggtgggc
238741 aatgcgacgt tggtcgtctc caccgggctg cgccgccggt agccggggcc cgcccggtga
238801 gtctgcaccc ccccgcactc ccaggtggtt gtctgaagcg cgtcgagggc gaccgcgagc
238861 cgcttgcgcc acacggtgac cgggtgcacc gggcgctggc cccatgatat cgcccgggcg
238921 atgccgttgc ggtaggccag ctgcacctgg tcgagcgcct taccgtcaca tccacacccg
238981 gtgaaggcga gcggatcggt aacgcaaatg gcgtccggcg caagtcgctt gagcttggcc
239041 gccgacttga gcaccatccg cacatccgcg ctgggcggga tcgccgcggc gaagtcgtca
239101 ggaatgacca cgacgtcacc gaggtcgact ttcggcagcg gtcggtcgaa gtcgaccgac
239161 ggcaagatgt gggccagcca tcggggcaac caccagttcc atcggtcaaa catcgccatc
239221 aatgccggta ccagcaccag ccgcacgacg gtggcgtcca cggcgatcgc gaccgcgcac
239281 gccacgccga tctcggccac tagcggcatg ccggcgaacg cgaacccgca aaacaccgcg
239341 atcatgatca acgcggcgct ggtgatcgtg cgcgcgctgg tgcgcacacc gtacgcgacc
239401 gcgtcgcggg tctggcccgt ctgcaggaac cgctcccgga ttcgcgtaag caggaagatt
239461 tcatagtcca tcgacaaccc gaacgtcatc gccaggacca gcgggggaac ggtgctgtcg
239521 atcgaatgaa gcgccgggaa accgagcccc cgtgcccagc cccactggaa gaccatcacc
239581 aggctgccgt aggcggcggc caccgacagc agcgtcatca gcacgccctt gaacgccagg
239641 aacaccgagc ggattgagat caacaacatc aaaaacgcga tcaccgccac gaagaccagc
239701 accagcggtt gcgtcgcgga cacccggtcg tcgaaatcct tgatcagagc ggtcggcccg
239761 ccgacgtcca cttgtgccgc gccggcaacc cggggtagct gggtccgcat ccaggtgatg
239821 gtgtcgcggg cgcccaaatc ctcgggatcg accgatagca ccgcgctgag caaagcgctg
239881 ccgttgtcgt cggcgaatcg cggtggggcc accgaaacga cgttgggcgc ctgtgcgatc
239941 cgatgacgga ttgcggcgat tgtctggcta tgttcgggtg cggacgcacc gccggcgtca
240001 aacctgacca gcacctgaac cgggcccagc gcgcccggcc ccagcgcttg ggccgcggcc
240061 gctgcgccgg tgcggatctc gtgtgacgag tcgaactggc gcagcaagct gttgcccagc
240121 accatcaagg ttgccggtgc cgccatgaca agcagcacgg tcgatgccgc cagtgctgtg
240181 atccagggtc ggcgcatcac ccacccgacc cagcgggacc agaaccaaga ttgcgtgctt
240241 gccggccgcc gcgaccagtg cactaacgct gaccgcttgg ccgccgcgcg ggcaaatgtt
240301 gctagcacgg caggtgtcag ggtggccgac gtcagcatcg caaccgcgac cgcgagaatc
240361 gccccggtgg ccatcgatct cagcgccggg gtgttgatca ggtagatccc ggtcagcgac
240421 gcgatgaccg tcataccgga caacaccaca gccaaccccg aagtggccat cgcggcgtcg
240481 accgcgtcgg gcggccggcg tccgcaacgc agttcctcgc ggtagcgcat caggatgaac
240541 agggagtagt cgacggcaag cgcgatgccg aacatcgaaa cggtcgatgt cacgaacacc
240601 gacatggtgg tgtgcatcga caacacaaac accaggccca tggtgatgac gaccgtgcaa
240661 acggcgagtg ccagcgggat cgctgcggcg gccaacgagc cgaaaaccgc aaccaggacc
240721 atcagaatga taggcaggtt ccagcgttcg gcgttggcaa tatcgtgttt ggtgtttgcc
240781 gccgcggccg cggacagcgc gccctgcccg atgacataga gccgcacttt gccgttggca
240841 gtttgcccgg actgatcgcc tttgacgcct attcggtcgc gcagcttttt ggcgacgtca
240901 ctggtgcccg cgttgcgggc gtccagccgc agcgacacca catacggccg gtccggttgc
240961 gggggccgtt gggtggggtt gggtgcctcc gtcaccccag gcagttcgct ggctatttgt
241021 cgcagtagcg cgacggcatt gtcgatgtct tggtagctag catccggtcg gggggccgct
241081 accagcgcca gcgccggggc tccccggtcc gggtagtgcg cgtcgagttg gtcgtggacc
241141 agcaatgact gcgacccggc gacttcgaaa ccgccaccgg ttagattccc cgactgcgtc
241201 atcgccaggt aaaccgccgg cactaacgcc agcaaccaac ccgtgaagac caaccaacgg
241261 cacctgcgca ggttgcggct caagcgcatc atgaactgct ggatttcgga ctccccgtac
241321 tctcgcgcag tgcgtgcccg cgagcctacc gaagatcgcg tgcatgcgtt cggcgtggac
241381 cgcacagcac ctggagttgg cggcgccgag ggccgagatg gcaggatgac ggatcgtcgg
241441 gggcgggaac tcccaggccg ccgggccgtc gcaaacccgt cgcaaacccg tcgcaaaccg
241501 taaggagtca tccatgaaga caggcaccgc gacgacgcgg cgcaggctgt tggcagtact
241561 gatcgccctc gcgttgccgg gggccgccgt tgcgctgctg gccgaaccat cagcgaccgg
241621 cgcgtcggac ccgtgcgcgg ccagcgaagt ggcgaggacg gtcggttcgg tcgccaagtc
241681 gatgggcgac tacctggatt cacacccaga gaccaaccag gtgatgaccg cggtcttgca
241741 gcagcaggta gggccggggt cggtcgcatc gctgaaggcc catttcgagg cgaatcccaa
241801 ggtcgcatcg gatctgcacg cgctttcgca accgctgacc gatctttcga ctcggtgctc
241861 gctgccgatc agcggcctgc aggcgatcgg tttgatgcag gcggtgcagg gcgcccgccg
241921 gtagatgccg gaccgccgcc gggtccggcg cagtcgagcg tgaggcagcg gtcgcctacc
241981 ggggcggtgt ctcgccgcct tctggtcgca ggtcaggggt cggcgctgga ccttgcggtg
242041 tggtttcgac cgggtcgtcg cagggtgtgc cctgcggttg gatgacaagt cgcaggtttg
242101 gatcggttgg cgggtcgcga tcgttgtcgg aatcggcggt gctctcggtg cggaacatga
242161 agaagaacac cacccagccg attgcggcga tgagcagcca gctgatcagc cggtagatca
242221 acatcgccga gatggcactc ggcaagggca tgccgctgga taccaggccg ggtaccagca
242281 ccgcctcgac caccaacaga ccaccgggca tcagcggtat ggtgccgacc gcgcgggcgg
242341 cggcgtaggc gaccgccagc ccaccgaccg aggcatggtc gccggcggcg tacgcggcga
242401 aaccgaggca ggctacgtcg gcgatccagt tgaacaacga ccaaccgaac gccacgccca
242461 ggtcgcgcct gcccaggctg accgattcca gctgcatgag cgtctcgcgc cacttcggta
242521 ggccggcatc ggccggccta ccgcgaaccg agttggccca cgacaaaact ctcctgccga
242581 tcccctcgat gagctccggc cgcgacgcca ccgcctgggc cagtagcagc aatgtgacga
242641 agccgcccag ggtgaacagc agtgagaacg ggttgttctt ggcgcccagg aagaatgcgc
242701 cacccaaccc gagcaatgcc aagcccaccg cctgcaacac gcccgacatg accagctgcc
242761 atgacgccac caccgtcgag gcgccccaga tgcgttgctg acggagtaag aacgtagccg
242821 acaacaccgg cccacccggc agcgtggtgc tcagcgagtt ggcggcgtag aaggcggcct
242881 ccgaccgcca ttgcttgacg tgcaccccgg cggatttcag cagggttcgc tgaatctggg
242941 cgaagctgtg catcgaggcg cccgcggctg ccaccgcggc cagcaaccac caccacttgg
243001 cgcgatacaa gctcacccag gccttggcga gctggtccca gcccaacgcc acctctatag
243061 caagcacgat tgcgacgatg gccagtaccg cccatcgcaa ccaccagtac ttgccgcgcg
243121 ggggtacgcc ctcagcgggg ggtgccccca cccgcgtgcg agggagtgcc cccacgcgct
243181 ggcggaggtt gcgggcgggg gcgtcgtgcg acacgtgctt aagggtaacc gtgcaggtgg
243241 cgccgtaatc gcgatacatc gctaaccgtg tcagcctcgt tggggggtcg tgaccggatc
243301 gtgccgcctg gcaaagtaac tatgcgggct cgacgcgacc cgccgcgacc ttacgacgcc
243361 gccgttcccg ttacgcttgc cggatgtcgg cgagcctgga tgacgcttcg gtcgcaccgc
243421 tggttcgcaa gaccgcggcc tgggcgtggc ggttcttggt catcctggcc gcgatggtcg
243481 cgctgctgtg ggtcctcaac aagtttgagg tcatcgtcgt cccggtgttg ctggcgctga
243541 tgttgagtgc gttgctggtg ccgccggtgg attggctgga ctcccggggc ctgccgcacg
243601 ctgtcgcggt gacgctggtc ttgttgagcg gtttcgcggt tctcggcggc atcctgacgt
243661 tcgtcgtcag ccaattcatc gcggggttgc cgcatctggt caccgaggtt gagcgcagca
243721 tcgactccgc gcgcagatgg ctgatcgaag gcccggcgca cttgcgcggc gaacagatcg
243781 acaacgcggg caacgccgcg atcgaggcgc tgcgcaacaa ccaggcgaag ctgaccagtg
243841 gcgcattgtc gactgcagcc accattaccg agctggttac cgcggcggtg ctggtactgt
243901 tcacgctcat tttcttcctc tacgggggcc ggagcatctg gcagtacgtc acgaaggcct
243961 tcccggccag cgtccgtgac agagtgcgtg cggcggggcg cgccggttat gcgtcgctga
244021 tcgggtacgc gcgggccacc ttcctagtgg cattgaccga tgcggccggg gtgggcgcgg
244081 ggctggcggt gatgggtgtg ccgctggcat taccgctggc ctcgctggtg tttttcggtg
244141 ccttcattcc gttgatcggt gccgtggtcg ccgggtttct ggccgtggtg gtggccctgc
244201 tggccaaggg cattggctac gcgctgatca cggtcggttt gctaatcgcg gtgaaccaac
244261 ttgaggccca tttactgcag ccgctggtga tgggtcgggc ggtgtcgatt cacccgctgg
244321 ccgtggtgct ggccattgcc gctggcggtg tgcttgccgg agtcgtcggc gccctgttgg
244381 ccgtcccgac ggtcgctttc ttcaacaatg cggtgcaggt gctgctgggc gggaatccgt
244441 tcgccgacgt ggcagacgtt tcttccgatc acctcaccga ggtttaaagg cgtccttcgc
244501 ggcgaagcag atcctgggcg gacagggcgc cgccgccgcg gcggcgctga cgcgtcttat
244561 cgctcgtgcc gcgggcattc agctgctcag tggctgcctc tgagtcgtcg ccgtccgacc
244621 gtatgattgg cagggccgcg gtgggttcgg ccgggtcacc ggctgcgtct gtggagcggt
244681 tcgccgcaag cggcatagcc cgggtctgac cggcagacgg ggccgatggc ggggtcgggg
244741 ttggtggcgg cgtggatgct ggcgactgca cggaccgacc ggcagccgcg aggcgggttg
244801 tcggcggctc cgtcgacgac ccgatctgca tccgtgtggt gctcgcccca gacggcgccg
244861 ccggcgcggc agttgcttcc agggcaggcg tgagctccgg tgagcttgct ggactcgagc
244921 gggccggtcg aggtgactcc gccagcggat gggtcggatc gtgcggtggg cgcgggtccc
244981 cagcggcgcg cgccgcaacc agcccagctg tgaccggagg acgtgcggga cgcccgttgc
245041 tgacgggccg cttgcgctcg tcgggcaggt ggatctcgcc cagcccgatg cgggtctgca
245101 ggcgtctggc ccagcgcggt gcccaccagc agtcatcgcc gagcagcttc atcaccgatg
245161 gcactaaaaa catccgcacc acggtcgcgt ccagcagcag cgccgccatc agtccaaagg
245221 ccagatactt catcatcacc aggtcggaga acacgaacgc gcccgcgacg acggcaacaa
245281 tcagcgccgc ggcggtaatg atgcgtccgg tggctgcggt gccgatccgg atcgcctcct
245341 gggtcgacat gccgcgctct cgcgcctcga ccatccggga caccaagaac acctcgtagt
245401 cggtggatag gccgaagacc agcgcgatga tcagcccgat caccggcgct gtcagcgggg
245461 tcggcgtgaa attcagccac ttcgaaaagt gtccgtcgac gaatatccac gtcaggatgc
245521 ccatggtgga cccgagcgtc agagcgctca tcagcgtcgc cttgattggc agcaccaccg
245581 agccgaacgc caagaacatc aagacgatcg tggtggtcag caggatgacc accatcagcg
245641 gcatcttcgc gaacaggccg tggattgaat ccagctccag ggcgggagtt ccaccgacca
245701 agaccgtgat tcctttgggc ggggtgatcg cgcgcagctc ggtgagcttc ttcgacgcgt
245761 cagccgggtt gatcaacccg ttctgcagga cgcgcaccga tggatcttta gatgcgccta
245821 ccgcgtaggc acgctcttgc cacatattcg ccggatcgtt gtccggctcg atgaatccgc
245881 cgatcgccat cgccttgctg cggatgtcag cgatctgcgc gtcggtgacc ggttgatggt
245941 tgctggtctg gatcaccagt gtcagcggat tggtgcggta tccggggaag agtttgtcga
246001 actcctcctg cgcctggcgc accgaattgg tcggcggcaa gtacttctcg ctgatcccgc
246061 ccaatgacag cttgcccacc gggataatca gcaaaatcat gatgatgacg atcggtgcgg
246121 cgaacagcac tgggcgcttc atcacccggt taaccagctt gccccagaag ccggcttcga
246181 cctcttcgcg ggtcttggtc cgctgcaggc ggtcggcgag ccagttcagg taggcggccg
246241 aaatcttcca gttcgccagg aagggcaccc ggaacagggt ccgcacgccg agcgcgtcga
246301 cgtgtttgcc caggatcccc agacaggccg gcaacacggt gatagacagg atggccgaca
246361 gcatcaccga tgcgatcgtg gcgtaggtca gcgacttcag gaaaccctgc gggaagagca
246421 gcagaccgat cgccgacgcg acgatcaaca ccgccgagaa cgtcaccgtg cgtccggcgg
246481 tgatcaccgt gcgccgtact gccgtctcgg tgtcgtagcc ttcggcgatc tcttcgcgga
246541 accggctcac gatgaacaac ccgtagtcga tggcgatccc cagaccgatc agcgacacca
246601 cgggctgggc gaaatagtgc acgggaccga agatcgcgag gaaccgcatg atgcccagcg
246661 cgccggcgat gcacagccct ccgaccatca ccggtaggcc ggcggcgatc acgccgccga
246721 acacgaagaa caacaccacc gccaccaacg gcagcgccag cacttccatt cgccgttggt
246781 cggtggcgat ggtgccggtc aacgcctcgg ccaccggttg cagcccggcg agcttcaccg
246841 tgcctccgtc gagccgctgc aggtcgggtg cgatggcctt gtagttgttg aggatggtgt
246901 cgtcgtcatc acccttgagc gggatggaaa cgaaggtgta cttcttgtcg gcggtggcca
246961 tgccggtcgc ctgactcgct ctcaggtagc cggcccatcc caagacctgg tcggggtgat
247021 cctgctggaa ccggttgagc tcgtcgacga ccttctttga ccaggccggg tcgtcaacgg
247081 tcttgccggc tggggcttgg aagatcgcga cgatgtgacc gcttcggtct cggccgtaga
247141 cctggtcgcc cagcaccgat gcttgcaccg attggctgcc gtcgtcgtag aagccgctct
247201 gcgtgacgtg cttgccgagg ctcagcccga aaacgccgcc gccgaggcat agagcgacca
247261 tgaccccgat tacgatgaac cggtagcggt acacagttcg accccaccag gcgaacacgt
247321 aagctcctta ctggatcggc agcgacccgc gtattgcttt ttggttgtca cacacgtcgg
247381 ctgtcacact cgcgaggtca acagcgagga cagcggccgg aacggctgca gccaagcccc
247441 ctgctcaggt agcgaatcga ggccgattcg aggtagtggt tcccggaaaa caccagcgat
247501 gtcctccagg tcgacgaact ccaaggtatc cgacgctagc gcccaactgg cgtgttcacg
247561 aaatccgagc acttgaactg gggttccgct gcgggcgacc gcctccaacg gttggcggaa
247621 tgcctgaccg tcggccgacg ccaccaccag cgcggcgagc ccttcgcggt agcgctcgtc
247681 gatgtgcgcc aacatgtcgc ggtcaacgtc gctgtcctcg tctactttcg gtttggcgaa
247741 gacggcgaat ccgacattgc gcaacgcgtc cacccacggc cggaccacct cggcgctgcc
247801 aggggcgatg ttggtgaaga cggtggcctc cggttcggtc gagatgcctg gacggccggc
247861 cacaatctct gcggttcggg ccagcagcca gcgtcccagg gcgtcgaatc gtggtcgttc
247921 cagtgctgtc ggccggcggc ccaagatgga gcccaaaccc atgtcgaggt tgggagcgtc
247981 ccacaccagc aatacccgtg cccccggcgc accgagactg gtcagcccgt cctgcgataa
248041 gtcttccgcc agtaccgagt gccgggcgag ggattcagat gtttgtgaag tcacgtcttc
248101 ggtcaggctc atcatcatct aattttcagg tctctttcag agcaaccgtg ctttttccat
248161 aacaactcga tgactgcgcc gcccccaagc tgggctttcc tctcgtactt ggtagccggt
248221 cggacgaccg aaatcggcag cagttcggtg tcggggtcga cgcgaaccag ccggggttcg
248281 gcgtcgccgg ccgcggcgat gtgctcggcg tagccgggat ggtcggtcgc ggcgtgcagc
248341 acaccactgg gaacgagccg gtctgcgatc aaggccatgg tggccggctg taacaggcgg
248401 cgcttatggt ggcgtgcctt cggccacgga tcggggaaga agactcgaac accgcacaac
248461 gaatcggggg cgatcaagtg ttgcagcacg tcgacggcat tgccaaggat cagccggatg
248521 ttgatcccgt cggagcccac tttgtcaatc gcgcagagca gctgagccag cccgcggcga
248581 tagacgtcca cagcgatcac gtcgacatgg ggttcggcct tcgccatcgc cagcgtcgac
248641 gtgccgctgc cggagccgat ctccaacacc accggcgcgt cacggccaaa ccaggcacgg
248701 gtatccaccg gtgtcccgcg cggggattga ggtagcgcca ggaggccaag ctccggccaa
248761 agtcgctccc aggtctcgcg ttgggccttg gagatccccg accgccgcga ccggatgctc
248821 gtgctgggga gctggcccga tgccaccggt gtgtcgggac gtagccctac cccgggttgc
248881 gcatgcattt gtccatggtg gaccatcagc gcccggcgta gccgcccctg gtccagattg
248941 atacccaaca gttgccttcg gcgggtagcg gacaactgct gactcgcgcc tcggcggcga
249001 gggtgccacc attctgaacg aaccgatcgg gtgggagatg cgcggacaag ggcaccagat
249061 tttcgtcgac gagctggcgc gattcgccac cagctccgcc gaccagcggg tagtggcgat
249121 cgcgcagcgg gccgccgaac cgctgcgcgt agcggtccgt gggcgtcccg gggtgggttg
249181 ccgcacggtg gcgcgcgccc tgcagggtgc tgggagctcg tcgggcatga cggtgacacc
249241 gcaagcacgc gccgccgact ctgacgtcga cctggtcgtc tacgtcaccg tcgaggtagt
249301 caagcccgag gaccgcgaag ccatcgccgc cacccggcgc ccggtggtgg cggtgttgaa
249361 caaggccgat ctggccggcc cgctctcggg tgcaggtccg atcgtgatgg cgcaggcccg
249421 gtgcgcgcaa ttttctacac tcctcggggt ccccatggag tccatgatcg ggttgctcgc
249481 cgtcgcggcg ctcgacgatc ttgatgacac cttgcgggcc gtgctgcggg cgctagccgc
249541 ccaccccgac ggctttgacg ctctcgaccg agccgttgcg gggtttctgg cggcagccct
249601 gccggtccct accgaggtac ggttgcggtt gctggacacc ctcgacctgt tcggcatcgc
249661 actgggcatg gcagcgttcc ggccgggccg gccctcgcga accccggcgc agctccgcac
249721 cctgttacgc cgggtcagcg gtgtcgacgc cgtcatcgac aaggtcaccg ccgccggttc
249781 tgaggtgcgc taccggcggt tgcttgacgc ggtcgcggag ctggaggcgc tggccgcgca
249841 ggccaaggag atcggcggtc cgatcggtga gttcttgcgc gacgacgaca cagttctcgc
249901 ccggatggcg gccgccgtcg acgtagccct ggccgtcggg ctagacgttg gcccgttgga
249961 cgatccggcc gcccacctgc cgcgggcggt gcggtggcat cgttacagcc tggacaacgg
250021 tgacatgcac cgcacgtgcg gcgcggatat cgctcgggga tcccttcggc tgtggtcgct
250081 ggccggcggc atgcccctgc accgataccg gaagtcatcg tgatccgcgc ggctagtgat
250141 gacccggccg gggtggacga gctggtggca gcgatcgcgc cggggcttgc cgggctgggt
250201 ttgccggtca tcaaccgccg cgaggtggtg ctggtgaccg gtccgtggct ggccggggtt
250261 agcggtgtgc gcgcggcact ggccgaaagg ctgccgcagc gtaggttcgt cgagacggca
250321 gagttgggac ccggcgatgc gccggtggcg gtggtgttcg ttgtttccgc ggcaaccgcg
250381 ctgaccgaat ccgattgcgt gttgctggac accgccgcgg agcacaccga tgcggtggta
250441 gctgtggtgt ccaagatcga cgtgcaccgc ggctggcgtg acgtgcttac cagtaaccgc
250501 gacaggctgg ccgcgcgcgc gtcccgctac gcccgggtgc cctgggttgg cgcggccgcc
250561 gcacctgagc tgggcgagcc atacctggac gacttggtcg ccgccatcca gaaacagctc
250621 gccgatccgg ctgtcgcgcg gcgaaacatg ttgcgtgcgt gggaatcccg gcttctgatg
250681 gtcgcgcggc ggttcgatgg cgatgcacag agcgccggtc ggcgggcacg ggtcgacgcg
250741 ttgcgccagc aacggcgcac ggtcctgcgg caggggcgtc aatcgaagtc tgaacacacc
250801 atcgcgctgc gcgcgcagat ccagcacgct cgggtcaaat tgtcctactt tgcccgcaat
250861 cggtgttcgt tgctgcgcgt cgagctgcag gagcacgtcg ccggtctgtc ccggaaggac
250921 atcgccaggt tcgcggcata cacgcgcggc cgggtccagg aggtggtcgc cgaggtgggc
250981 gaaggtgccg tcgcgcacct tgccgacgtc gcgcagctgt tgggtgtgcc ggtgcagcca
251041 ccggtcctcg agaacctccc ggcggtgctc ccgacggttg tggccccgcc actgacatca
251101 cgacgattgg agatccggct gacaacactc ttgggcgccg ggttcgggct gggtatcgcg
251161 ctgaccctga gcaggctggt ggcgggtctt actcccggcc tggctgcatc ggggatggtg
251221 gcgggtgtgg cgatcggcct ggcggtgacc gcctgggtgg tgaatgcccg cgcgctgctg
251281 cacgaccgtg tcgtggtgga ccgctggacg ggtgaggtga cggcatcgct gcggtccgtg
251341 gtggagcagc tggtcgccac tcgggtggtg gctgtcgaga cgctgctgag caccgcgatt
251401 agtgaacgcg acgacgccga gaacgcccgg gtggccgatc aggtcagcat cattgacggc
251461 gaactgcgcg aacacgccgt cgctgcggcg cgggccgcgg ccctgcgtga ccgggagatg
251521 ccggcggtgc gggccgcact tgaggcggtg cgtgcagaac tcggcgagcc gggtgcgccc
251581 acaacaggcc tgttctgaag cttctgaatc gttgttgtga gcaggcttat acccgcccaa
251641 gtcttccctg acaagttctg ggcgataatc tggataaaaa gtgtctcact aggtgagcgg
251701 ccgtatcagc ctcgccacca agacgggcat acctaaccca tacgtaaccg cgagcacccg
251761 ataactacgc aggagaattc gatgacctca gcgaccatcc ccggtctgga taccgcgccg
251821 acgaatcacc aggggttgct gtcctgggtc gaagaggtcg ccgagctcac ccagccggac
251881 cgggtggtct tcactgacgg ctcggaagaa gagttccagc ggctctgcga tcagctagtc
251941 gaggccggca cgttcatcag gctcaacccc gagaagcaca agaactccta cctggcattg
252001 tcggatccgt ccgatgtcgc gcgggtggag tcgcggacgt acatctgctc ggcgaaagag
252061 atcgacgccg gccccaccaa caactggatg gatcccggcg aaatgcggtc catcatgaaa
252121 gacctgtacc ggggttgcat gcgcgggcgc accatgtatg tggtgccgtt ctgtatggga
252181 ccgctgggcg ccgaggaccc caaacttggt gtggagatca ccgactccga gtacgtcgtc
252241 gtctccatgc gcaccatgac ccggatgggc aaggccgcgc tggagaaaat gggcgacgac
252301 ggtttctttg tcaaggcgct gcactcggtc ggcgcgccgc tggaaccggg ccaaaaggac
252361 gtggcctggc cctgcagcga aaccaagtac atcacccact tcccggagac ccgggagatc
252421 tggagctacg gctcgggcta cggcggcaac gcgttgctgg gcaagaagtg ctactcactg
252481 cgtatcgcgt cggcgatggc ccacgatgag ggctggctgg ccgagcacat gctgatcctc
252541 aagctgattt cgccggagaa caaggcttac tacttcgcgg ccgcattccc gtcggcgtgt
252601 ggcaagacca acctggcgat gctgcagcca accatccccg gctggcgtgc ggagacactc
252661 ggagacgaca tcgcatggat gcgatttggc aaggacggtc gcctgtacgc cgtcaacccg
252721 gaattcggct tcttcggggt ggcgccgggc accaactgga agtcgaaccc taacgccatg
252781 cgcaccattg ccgccggcaa cacggtgttc accaatgtcg cactcaccga cgacggcgac
252841 gtgtggtggg agggcctgga aggcgacccg cagcacctga tcgactggaa gggcaacgac
252901 tggtacttcc gcgagacgga aaccaatgcg gcacacccga actcccggta ctgcacaccg
252961 atgtcgcagt gcccgatcct ggcccccgag tgggatgacc cgcagggcgt cccgatctcg
253021 gggatcctgt tcggcggccg ccgcaagacc acggttccgc tggtcaccga ggcgcgcgac
253081 tggcagcacg gggtgttcat cggtgcgacc ctgggtagcg agcagaccgc cgcggccgag
253141 ggcaaggtcg gcaatgtgcg ccgcgacccg atggccatgc tgccgttttt gggctacaac
253201 gttggggact acttccagca ctggatcaac ctgggcaagc acgccgatga gtccaagctg
253261 cccaaggtgt tcttcgtcaa ctggttccgt cgcggtgacg acggtcgctt cctgtggccg
253321 ggcttcggcg agaacagccg ggtgctgaag tggatcgtcg atcgcatcga gcacaaggcc
253381 ggcggtgcga ccaccccgat cggcaccgtt cccgccgtgg aggacttgga cctggacgga
253441 ctggacgtcg acgccgccga tgtagccgcg gcgctggcag tcgatgccga tgaatggcgt
253501 caggaactgc cgctgatcga agaatggctg cagttcgtcg gcgagaagct gccgaccggt
253561 gtcaaagatg agttcgacgc cctgaaggag cgcctaggtt agggcgagca gacgcataag
253621 cccccgcacg cacggcgtgt cgagggcttt agtgtctgct cgcgctcgtt agcggcgggc
253681 acgcacaagt tcttcgacag cgcgcaaaga caccgaaagc ctctcttccc aaccgcccgt
253741 gatcaccacg aatgatcgtc ccgcggcgcg gagagcctgc tcgcagcggg cgaaaaaggt
253801 accgcgtgcg ccggggacac agcgtccgtc gtcggcgtcc cagggcacat cgggcgtggt
253861 gagcagtgtg agatcgtagg gacgccgagc tagatcacgg agctcttgcg ggcagccgcc
253921 cgccaggaac tcggcccaca cggtcgtcgc gagcggatcc gtgtcgcaga tcaggacgcg
253981 atcggcgtca cgagccaagg cttcctccga cgcgatctgt ccgcgaacga tttcggccca
254041 ctccagtcct atcagtgagc cgccattgag ctcccgcaac attttcgccc gctccgggac
254101 ccacttcgtt cggagctttt ccgcaaccgc ctgtgccagc gtggtcttcc cggtggattc
254161 gggtccgatg atgctcacgc gtttgacgaa ggccggccgc acgcaccgtg ggatgtgttg
254221 ccagtggcca agcgggtccg cgcggatgtc ggttgcagtc acgggaacga cggtgcgacc
254281 gtgatcgacc gccacgaaac gcgctccgag gacctgggca aagtccgcgt tgtagggctc
254341 ggcaccgaag acgaagtcgg ggcgggttgc cagcacgccc tgcaggctcg ccttccagat
254401 gtcccagaag tccgggtgct cccacgggcg ctgcgggttc tcgttggcca gatggaccac
254461 gcgatcgaag gggaacagct cccgcatcca tgcaacgcgc tgggcgcccg gaatcggctc
254521 tgctgccgtt gatccgacga cgatggtcag ctcatccacc catcgccgcg cgaactcgca
254581 aaggtagacg tgtcccgcat ggggcggcat gaacttgccg agcaccattc cgtgtgtcac
254641 gacgtcgcct cagcgattcg gccggcgatg acattctccc actcgtccag ccgcgaaaga
254701 aagtacgcct cagcctcatc gaagctgatt ccgacgtcag gagcgacctt ggctacgacg
254761 tcggcgtaga cccgggaggc ctctgggtcg acgaattccc actgaccgag gggccatttc
254821 gcggtgagat aacccgcgtc cgagtacgct tggtacaacg gcgttcccgg ataggggacg
254881 atccggctca tgaacttgaa gccgaccgta tactttgttg cccgcagcag gcggactgtt
254941 tcgcgtagct cgtcgggctg cacggtgggg tgaaacataa tggtgcccgg gataacgtca
255001 atgccgagct gttgcagggc gttgatcgtg tcggcggcat cttgtccacg agtgaggatc
255061 tgcttgcggt aggcgcgcag ttgctcgtag gacccagtct ccacgccgat gaatacccga
255121 cgcaggcccg ccctgtgcag atgtttgaac aagtccagat cgacaacgga gtccagccgg
255181 atatcgacca tgaagttgac gctgatcccc ctcctgagta ccgcgttggc aaagtcagcg
255241 gcgcgttgct gcgaaccggg gtgtttggag ataaacaggt cgtcggtgat ggataggaag
255301 ttgacgtcgt agtccgacac cagataatcg atctcgtcga cgaccgcgtc aaccgacttc
255361 gcccggtagc tgtccttccc tagcatcgcg gacatggccc cggtgccgca gaacgtgcag
255421 cggtaggggc atccgcgggt ggaaaagacg gaggcggcga agccatcagc aaggacggtc
255481 ggcaactcgt cgcgagccgg gcgaggcaac tcgtcaaggt cgaccagcga ggagggtgtg
255541 cgcaggatct gtccctgctc actacggcgg gctagtcccg ggacgtcgtc aaccgcagcg
255601 tcattcgcca gggccaaggc cagcttggtg aacgctacct ccccgtcgcc aacgacgacg
255661 tagtcgaaac agtcatgctg gcgcaggatg cgctcgtagt tcagtgttgc catcgcattc
255721 ccgatgacga tgcgcacgcc atcccaggcc tgtctcgcgc gctgcgccaa ccacaacacc
255781 tccggaaatg tgtcgatgca ggaaaagccg acaagccggg gcgttcctga taaggcggcg
255841 gcgctttgca tggccagcca cgtctcctgc acggacccgt ggccggcgac caggccgttg
255901 acggaggtga ctgcgatccc ttgggtcttg gcgtatgcct tgatcgacat catcccgagg
255961 tgctccatgg gcatggagca atacagccac ggatctccaa gcttgagtcc gtcaacgtac
256021 gacagcccgt cttgacggac gcctggagga ttgaccagaa gagttgccac gtggagaact
256081 ttacaaacga tttcggctgg tgatgggcgg aattgcgccc tgcggctctg gtcgccgggc
256141 cgcgacgtac cctcggcgca tgcagattcg cccgtatatc ggcgccgata agcccgccgt
256201 catcctgtat ccgtccggga cggtcatcag cttcgacgag ttggaggccc gcgccaaccg
256261 gttggcgcat tggttccgcc aggctggtct gcgcgaggac gacgtcgtgg ccatcctgat
256321 ggagaacaac gagcacgtgc acgcggtcat gtgggcggct cgccgcagcg ggttgtacta
256381 cgtgccgatc aatacccacc tgaccgcctc cgaggccgcc tacatcgtcg acaacagcgg
256441 tgccaaagca attgtcggtt cggcggcgct gcgcgagacc tgccacggcc tggccgaaca
256501 ccttccgggc gggctgccgg acctgctgat gcttgccggg ggcggtctgg tcggctggat
256561 gacctacccg gaatgcgttg ccgatcaacc agacaccccg atcgaggacg aacgcgaggg
256621 tgacctgctg cagtactcgt cgggaacgac tggccgaccg aagggaatca aacgcgaatt
256681 gccacacgtc tcaccggatg cggcacccgg gatgatgccg gcactgctcg atttctggat
256741 ggacgccgac tcggtatatc tgagtcccgc gccgatgtac cacaccgctc cgtcagtgtg
256801 gacgatgagc gcactggccg cgggcgtcac caccgtcgtg atggagaagt tcgacgccga
256861 gggcgccctc gacgccatcc agcgctaccg ggtgacccac gcgcaattcg tcccggccat
256921 gttcgtccgg atgctgaaac tccctgaagc agttcgtaat tcgtatgaca tgtccagcct
256981 taggcgagtg atccacgcgg ccgctccatg tccagtccag atcaaggagc agatgattca
257041 ctggtgggga ccgatcatcg acgagtacta cgcctcctcg gaagccagcg ggtcgacgtt
257101 gatcacagcc gaggattggt tgacgcatcc gggttcggtc ggcaagccca tacagggcgg
257161 ggtgcacatc gtgggcgccg acggcagcga gctgccgccg aaccagccgg gcgaaatcta
257221 tttcgagggc gggtacccct tcgaatacct caacgatccg gcgaaaaccg cggcgtcgcg
257281 caacaagcac ggctgggtaa ccgtcggcga cgtcggctat ctcgacgacg acggctactt
257341 gttcctgacc ggccggcgcc accacatgat catctccggc ggcgtgaaca tctacccgca
257401 ggaggcggag aacctcttgg tcgcccaccc caaggtgctc gacgcggcgg tgttcggcgt
257461 tcccgacgac gagatgggtc aacgtgtcat ggccgcggtg caaaccgtcg actccgccga
257521 tgccaacgat cagttcgccg gcgagctatt agcctggtta cgagaccgct tgtcacactt
257581 caagtgtcca aggtcgatcg cgttcgaacc gcaattgccg cgcaccgaca ccggaaagct
257641 ctacaagagc gggctggtcg aaaaatactc ggtgtgaccg atgctgccgg gggcccgacc
257701 tgtccaccca gacaccggct atatcccgcc ccgggccacc agttgtccgg ctatcacgtt
257761 gcgctggatc tcgttggtgc cttcaccgcc gttccacgtc gtactcggtc gagtagccgt
257821 agccgccgtg gatacgcacg gcgtttaggg cgatttccat cgcgacctcg gaggcgaaca
257881 acttggccat cccggcctcc atatcgcagc gttggccgct gtcgtaccgc tcggcggcat
257941 agcgggtcag ctgacgggcc gctgtgagct tggtcgccat gtcggccagg taattgccga
258001 ccgcctgatg ctgccagatc ggtcggccaa agctttcccg ttgctgagcg taggccagcg
258061 agtcctcgag tgccgccgtc gccacgccca gcgcccgcgc ggccacttgg atgcgacccg
258121 tttcaagtcc cttcatcatc tgcgaaaagc cttgacccat ggctccgccc aggatcgccg
258181 agaccggcac ccggaggttg tcgaacgaca gctcgcagga ttcgacgccc ttgtaaccca
258241 acttcggcaa gtcccgcgac accgtgagtc ccggcccggg ttcgacgagc acgatcgaca
258301 tgccttggtg ccgcggtgtg gcgttcgggt cggtcttgca cagcaccgcg aaaagtccgg
258361 accggcgggc gttgctgatc cacgtcttgc agccgttgat caacaacccg gcagagcctt
258421 cagggccgtc ggccaacgcc gtggtcgaca tgttctgcag atccgagcca ccgccgggct
258481 cggttagcgc catggtggcc cgcagctcgc cactggccat cgggggcaga tatgtccgcc
258541 gctgttcctc ggtgccaaac agggtcagca atttggcgac gacggtgtgc ccgcccatcg
258601 cgccggccag gctcatccag ccgcgtgcca gctcctgggt gacttgcaca tagcacggca
258661 tcgacaccgg cgacccgccg tactgttcgt cgatcgccag gccgtagatg ccgatgtgtt
258721 tcatctgctc gatccacgcc tccgggtagc tattggcatg ctcgacctca cggacggttg
258781 gcttcacgtc tcggtcgatg aatgcccgca cggtggcgac cagcatcgct tcgtcgtcgt
258841 tgagctcgtt gcgcaccttt tgtcgccctc cgtattgacc ccctgtccga tagcctgcca
258901 gcatgtggcg ttgtggctag cgggtatggg ggcatccgcg tcggcgggcc ctatttcgat
258961 gacctgtcaa aaggtcaggt gttcgactgg gcgccggggg tcacactgtc gctggggctg
259021 gcggccgccc atcagtcgat cgtgggtaac cggctacgcc tggctctgga ctccgacctg
259081 tgtgcggcgg tgacgggtat gccggggccg ctggcgcatc cgggcctggt ttgcgatgtg
259141 gcgatcggcc agtcaacttt ggcgactcag cgggtcaaag ccaacctgtt ctaccgcggg
259201 ctcaggtttc accgatttcc ggcagtgggc gacaccctct acacccgtac cgaggtggtg
259261 gggctgcgag ccaactcgcc caaaccgggc cgtgcgccaa ccggattggc ggggctgcgg
259321 atgaccacga tcgaccggac cgatcggttg gtgctcgatt tctaccggtg cgccatgctg
259381 cccgccagcc ccgattggaa acccggcgct gtgccaggtg acgacttgtc caggatcggt
259441 gccgacgcgc cggcgccggc cgccgatcca accgcacact gggacggtgc ggttttccga
259501 aagcgggttc ccgggccgca cttcgatgcc ggtattgccg gtgcggtgtt gcatagcacc
259561 gcagacctgg tcagtggagc gccggagctg gctcggctca ccctcaatat cgctgctacg
259621 caccatgatt ggcgggtcag cggacgacgg ctggtctacg gcgggcatac catcggactg
259681 gcactcgcgc aggcaacccg gctattgcct aacctggcga ccgtcctgga ctgggaatcc
259741 tgcgaccaca ccgctccggt acacgagggc gacaccctct acagcgagct gcatatcgag
259801 tctgcgcagg cccacgcaga cgggggtgtg ctgggactgc ggtcactggt ctacgcggtc
259861 agcgattcgg cgagtgagcc cgatcggcag gtgctcgact ggcgttttag cgccttgcaa
259921 ttctaggttc ggttactaag ggccagcgcg gcacgcaaac tgttgcactg actagtgaag
259981 aacctttgtg agaccccaac attcggggcc acacgatcga aaccgtggaa ggcgccttcg
260041 actacttcta cctggcatgg caccccggct gctgtcagac gttcggcata ggccagatcc
260101 tcgtcgtgga gcaggtcgtg ggtgccgacg ccgatccatg ccggcgccag ccctcctagg
260161 tcgtcacgcc gtcccgggac cgcgacccgt gcgtccgcat cgccaagata tgcccgccag
260221 ccgaaccggt tggcgcgccc gttccatagc cggtagtgcg ggttggcggg ggcgatcgac
260281 ggccggtcgt cgagcatggg gtacaccagc aactgaaatg ccggtgtgat gccgccacgg
260341 tcgcgggcaa gcagagccag cgccgccgcg aggccgccgc cggcactagc gccgccgatt
260401 gccacccgcg cggggtccac cgccggcagg ctggccagcc aggtcaacgc cgagtagcag
260461 tcgcccaggg cggcaggata cggattttcc ggcgccaggc ggtagtccac cgatgcgaca
260521 gtgatgccca gtctgctgct gaaccggagg cagagccgat cgtcctgttg cgcggtgccc
260581 attacgtatc cgccggcgtg gatccacagc agcgcgggcg ctggttcgtt gctgccggcg
260641 ggtcggtata gccggacacc gaccccggat tccagggtga gcacctcgat atcggggggt
260701 gtacgggaca ttcgaagccc cgcgacgacg atcaatgccc gcatgactgg cagggtgcga
260761 ggaccgacca gctgtcgtgg ggtgacgacg gcgatgcgac gcaggtcggg gtggacttcg
260821 ttgccggaca ccggtccagt atgcgtcggc gcaatttcgc ctcggtacag cgatggcttt
260881 ggcaggctgc ggttagtcga acgaggatcg ggatggtggc ctgatgagtg atccagcaag
260941 aggggcggaa gccgaggatg cctacggttt tcccgccggg ctgtggcgct ggctgcagcg
261001 gcatccaccg ccggcgttgc accggctcac ccggtttcgc agcccgttgc gtggtccgtg
261061 gttgacgtcg gtgttcggcc tggtgctatt ggtggcgttg cctttcgtca tcatcaccgg
261121 gctactttct tatatcgcct atgcgccgca gctgggccag gccatccccg gtgacgtcgg
261181 ctggctgcga ctccccgctt tcacctggcc cacccgtccg tcctggctgt accggttgac
261241 ccaggggctg catgtggggc tggggctggt gatcattccc gtggtgctgg ccaagttgtg
261301 gtcggtgata ccgcggctgt ttgtgtggcc gccggcgcgc tcgattgccc aggtgctcga
261361 acggttgtcg gtgctgatgc tggtcggtgg gatcctgttc cagatcgtca ccggcgtgct
261421 caacattcag tatgactaca tcttcgggtt cagcttctac accggccact attttggggc
261481 ttgggtcttc attgcgggtt tcctgttgca tatcgtggtc aagatccccc acatggtcac
261541 cgggttgcga tcgataccga tgcgagaagt gttgggtacc aacgtggctg acacccgggc
261601 gcagccgtgc gatccggacg ggctggtgtc ggtcaatccg ggcgaggcca cgctaagcag
261661 acgcggtgcc ctgggattgg tcggtgccgg ggtgctgctg atcggggtgc tgacggttgg
261721 gcaaaccctg ggcgggttca cccgcaaggc cgccctgctg ctgccccggg gccgtgtcgt
261781 gagcccgggc gacttcccgg tcaacaagac cgccgccgcc gccgggatca ccgcggaggc
261841 cattggcccc gactggcggc tggtgctgtg tggcgggcct gcggaagtag tgctggatcg
261901 cgccacgctg gccggcctgc cgcaacgcac cgcccggctg ccgctggcct gcgtcgaagg
261961 gtggtcggcc gtgcgcacct ggagcggcgt gccgctggcc gagctggcgc tgctggcggg
262021 cgtgccggcg gcgcgctcgg cacgggttac atcgctgcag cgcggcgggg cgttcggcga
262081 ggcgaagctg gcggcaaacc agatcgccga ccccgatgcg ctgctggcgt tgcgggtcga
262141 cggggcggat ctgtcgctgg atcatggcta cccggcccgc atcatcgttc ccgcactgcc
262201 cggtgtgcac aacacgaaat gggtcgctgg catcgaattc cacaagaggt gaaatgttcg
262261 acattgcaac gcgtttcaaa aactcctacg ggtcaggtcc attgcacctg ctggcgatgg
262321 tgtctggctt cgccctgctg ggctacatcg tggccaccgc caggccctcg gcgctgtgga
262381 accaggccac ctggtggcag tcgatcgcgg tctggtttgt cgccgccgtc gtagcccacg
262441 acctgctgtt gtacccgctc tacgcgctgg ccgaccggat cctggccagg ctagtcggca
262501 ggcgcgacgt ctcggcgccc cgccgccgcc cggaactacc ggtacgcaac tacattcgga
262561 tcccggcgct ggcagccggc ttgacgctgc tggttttcct gcccggcatc atcagacagg
262621 gtgcgccgac atacctggat gcgaccggac agacgcagga accatttctg ggcaggtggt
262681 tgctgctcac cgcggtcgcg ttcgggatca gcgcggccgc ttacgccatt cggctggtgg
262741 tggcgcacgt gaggcggcgc cgagcggggt gttcgcgggt cgacgcgatc gacgaggagt
262801 aggctcccac catgaaccag cgacgcgccg ccgggtcaac cggtgtggcc tacatcagat
262861 ggttgctacg tgcccgtccc gctgactata tgctggcctt gagtgtcgcc gggggttcgc
262921 taccggtggt gggtaagcac ctcaagccgc tcggcggcgt tactgccatc ggcgtctggg
262981 gcgcccggca cgcatccgat ttcttgtccg cgacggcgaa ggatttactg acccccggta
263041 tcaacgaggt tcgccgtcga gatcgtgcca gcacgcagga ggtttccgtc gcggccttac
263101 gcggcatcgt ttcgcccgac gaccttgccg tcgaatggcc ggcgccggag cgcacgccgc
263161 cggtctgcgg ggcgctgcgc caccgccgtt acgtccaccg ccgtcgcgtc ctctacggcg
263221 acgacccggc ccagttgctc gacgtatggc gccgcaaaga tatgcccacc aaacccgcgc
263281 cggtgttgat cttcgtccca ggcggtgcct gggtgcacgg cagtcgcgcc atccaggggt
263341 atgcggtgct gtctcggctg gccgcacagg ggtgggtgtg cctatcgatc gactaccggg
263401 tcgcaccgca tcaccgctgg ccacgacaca tcctggatgt caagaccgcc atcgcgtggg
263461 cacgggccaa tgtcgacaaa ttcggcggtg accgcaattt cattgcggtg gctggttgtt
263521 cggccggcgg ccacttgtcc gcgctggccg ggctcaccgc caacgacccg caatatcagg
263581 ccgagctgcc agagggctcc gacacgtcgg tcgacgcggt ggtggggatt tacggccgct
263641 acgactggga ggaccgctcc accccggaac gtgcccggtt cgtcgatttt ctggagcggg
263701 tagtggttca gcgcacgatt gatcgtcacc ccgaagtgtt ccgtgacgcg tcgccgatcc
263761 aacgagtcac cagaaatgca ccgccattcc tggtgattca tggcagccgt gactgtgtca
263821 tcccggttga gcaggcgcgg agctttgtcg agcggttacg agcggtctcc cgctcacagg
263881 ttggctacct ggagctgccc ggtgcgggcc acggcttcga cctgctagac ggcgctcgca
263941 ccggcccgac ggcacacgcg atcgcgctgt ttctcaacca ggttcatcgc agccgggcac
264001 agttcgcgaa agaggtcatc taaacgccgg ccaattgtat ggtcgcccta tgagtagggg
264061 gctgcggtga aacggctcag cggctgggac gcggtactgc tttacagcga gaccccgaat
264121 gtgcacatgc acacactcaa ggtcgccgtg atcgaattgg attcggacag acaggaattc
264181 ggtgtcgacg cgtttcgcga ggtgatcgct ggccggctgc ataagcttga gccattgggc
264241 tatcagctgg ttgatgtccc gttgaagttc catcacccga tgtggcggga gcactgccag
264301 gtcgatctca actaccacat ccggccgtgg cggttgcgcg ccccgggggg tcggcgcgaa
264361 ctcgacgagg cggtcggaga aatcgccagc accccgctga accgcgacca cccgctgtgg
264421 gagatgtact tcgttgaggg gcttgccaac caccggatcg cggtggttgc caaaattcac
264481 catgcgttgg ctgacggtgt tgcctcggca aacatgatgg cacgggggat ggatctgctg
264541 ccgggaccgg aggtcggccg ctatgtgcct gaccccgctc ctaccaagcg gcagttgctg
264601 tccgcggcgt tcatcgacca cttgcgccac ctcggccgga ttcctgcaac catccggtac
264661 accacgcagg gtctaggccg ggtgcgacgt agctcgcgca agctctcacc cgcactgacc
264721 atgccattta ccccgccacc gacgttcatg aatcaccggc tcaccccgga gcgcaggttc
264781 gccaccgcca ccctggcgct gattgacgtg aaggcgacgg ccaagttgct gggggcgacg
264841 atcaacgaca tggtgctggc catgtcgacc ggcgctctgc gtaccctgct attgcgctat
264901 gacggcaagg ccgaaccgct gctggcgtcg gtcccggtga gttacgactt ctcaccggag
264961 cggatctccg gtaaccgctt caccggaatg ctggtggcgc tgcctgccga ctccgacgac
265021 ccgttgcagc gggtgcgcgt ctgtcacgaa aacgcggtct ccgccaagga gagccaccag
265081 cttttgggac cggagttgat cagccgctgg gcggcttact ggccacctgc cggtgcggaa
265141 gccttgttcc ggtggttgtc tgagcgcgac gggcagaaca aggtactcaa cttgaatatc
265201 tcgaatgttc ccggtccgcg cgaacgcggc cgcgtggggg ccgcgctggt caccgagatc
265261 tattcggtgg gcccgttgac cgccggtagc ggattgaata tcacggtgtg gagttatgtc
265321 gatcagctca atatctcggt gttaaccgat ggttccaccg tgcaggaccc gcatgaagta
265381 accgcgggaa tgatcgcgga cttcatcgaa atacgccgcg ccgctggtct ttccgtggag
265441 ttgacagtcg tcgagtccgc gatggcgcag gcatgacacg aaacaccgga cgagtatgag
265501 gccagtatga gcagcgaaag cgacgcagcc aacaccgaac ctgaggttct ggtagaacag
265561 cgggatcgga ttttgatcat cacgatcaac cgcccgaaag ccaagaacgc ggtcaacgcc
265621 gcagtcagcc ggggcttggc cgatgcgatg gatcagcttg acggcgatgc cggcctgtcg
265681 gtggcaatcc tgaccggtgg gggcggttcg ttctgcgcgg gcatggacct caaggcgttc
265741 gcccggggcg agaatgtcgt cgtcgaaggt cgcggccttg gctttaccga acgtccgccg
265801 accaagccgc tcattgctgc ggtggaaggc tacgcgttgg cgggtggcac cgagctggcg
265861 cttgctgccg acctgatcgt ggcggccagg gattcggcgt tcgggattcc tgaagtcaag
265921 cggggtctgg ttgccggcgg cgggggattg ctgcggttgc cggagcgcat cccgtatgcg
265981 atagccatgg agttggcgct gaccggtgac aacctaccgg ccgaacgcgc gcacgagctg
266041 gggctcgtca acgttttggc cgagccgggg accgccctcg atgctgcgat cgcgttggcg
266101 gagaagatca ccgccaatgg gccgctggcg gtggtggcca ccaagcggat tatcaccgag
266161 tcgcgtgggt ggagtcccga cactatgttc gctgagcaga tgaagatcct ggtgccggtg
266221 ttcacctcca acgacgcgaa ggaaggtgcg atcgcgttcg ccgagaggcg ccggccccgt
266281 tggacgggca cctagcccag ctacgcgacg gtgtagccca tcggcagcag gacactcttt
266341 tgctgggtga agtgttcgac accctcgggc ccgttctcgc ggccgattcc ggagttcttg
266401 tagccgccga agggtgagcc gggatcgaag gcgtaccagt tgattccgta tgtcccggtg
266461 cggatctgct gcgagatctt gatgcctttg ggcacgtcgg tggtccacac gctgcccgcc
266521 agcccataca ctgaatcgtt ggcgatcgcg atcgcgtcct cctcggtgtc ataaggaatg
266581 atggccagca ccggcccgaa gatctcctcc tgtgcgatgg tcatcttgtt gtcgacatcg
266641 gcgaatacgg tgggttggat aaagaagccg ttgtccaagc cctcgggacg gccgccgccg
266701 cacaccaacc gagcgccctc ctcgatgccc ttggcgatgt agccttcaac gcgagtccgc
266761 tgcttctccg agatcagcgg cccgatctga gctgccgggt ccgacggcgg gcccaccggg
266821 agagccgtta cgaaattagt taccgcagcc acgatttcgt cgtaccggga gcgcggagcc
266881 agaatgcggg tctggttgac gcagccctgt ccggcgttca tgacgccgga gaacaccatc
266941 atcggaatag ctgcggccag gtcgacgtcc tcgagaatga tggccgccga cttgccgccg
267001 agttctaagg tgcacggctt gagcatctca gcggcacgcc tgccgacctc tcggccgacg
267061 gccgagctgc cggtgaaggt aaacatgtcg atgtccgggt tagacgtcag cgcctgaccg
267121 gtctcaatcc ctcccggcac taccgacaac accccctcgg gcaggcccac ctcggcgaac
267181 acctccgcca aagcgtttgc ggtcagcggt gtttcggcgg cgggcttgag cacgatggtg
267241 cagccggcca gcagcgccgg cgcaatcttg ttgacggcca gaaacagcgg gacgttccag
267301 gccacgatcg cgcccaccac accgaccggc tcacggctga caatgctctg tccataggag
267361 ccggtgcggg tttcggtcca ggtgaccttg tccgctgcac cggcaaagta gttcatcgcc
267421 cccatcgaac ccatccagtg catcgtctcg atgatggtcg gcggctggcc ggtttcggct
267481 gcgagcagct tggtgaacag gtccttgcgc tcagccagca tcttgaccgc cgcagcgatc
267541 accgccgcac gctcgtgcgg cggggtcgag ggccaggggc cgttgtcgaa cgccgcacgt
267601 gctgcggcga ccgcggcgtc gacgtcggcg gcggccgcca tcggcacctt gccgacatat
267661 tccccagtgg ctgggcagcg tacctcgata acatcggagg tcgacggttt ggtccacttg
267721 ccgccgatga aaagcttgtc gtattccgtg gcactgtcag acatatgcgc cgctcctcct
267781 catcgctgcg ctcggcatcg tcgccggcgg tcatggcgtc accctaccca agccgaacgc
267841 gaaacgagaa cgtgttccat tattagggtg tgagcaccaa taccagattg ctcaccagga
267901 actcacgcag caccgggacg gatgtcagcc accacgccca tctggggtgg tagcggggaa
267961 atacggctaa cgcggctccg gtgccggcag cccagcgcag accctcggcg gcggacacgg
268021 caaacaacga cgacccatag ttgttctttg ccggatggcc gtgtttgcgg acatatcggg
268081 cggcggcgcg ggcgccgccg aggtagtggc tgaggcccat ctcgtgcccg ccgaatggcc
268141 ccagccaaac cgtgtaggac agcacgacca acccgcctgg cttggtcacc cgcagcatct
268201 cggtgccaag ctgccagggg cgcggcacgt gttcggcgac attggaggac aagcagatgt
268261 ctaccgagtc gtcggcgaac ggcagtgcca tgcctgacgc ccggacgaac atgccgggcc
268321 ggccggtgaa cgcaggtccg gcggcatgca tttcatcagg gtccggctcg acgccgatgt
268381 agccgacacc ggcgtcggag aacgccgtcg cgaaataccc cggcccgccg ccaacgtcga
268441 gcagcgtacg gccaactggc ggctcgctat gtgtggccag ccacagatcg ccgatcattg
268501 ctgcggtgtc ggccgccagt gtgcgataga accgtgccgg gtcgcgctgc tcgtagcgga
268561 agtctgccag cagtcgcagc gagcgccgca gtgtcgcccg tcgcgcgaac acatcggtga
268621 ccgccacctg gcacacccta cggcccgcta ggctatcgac caatgtctgc tctgcgctcg
268681 gtgttgctgc tgtgctggcg cgacatcggg cacccccagg ggggcgggag cgaagcctat
268741 ctgcaacgca tcggggctca gttggccgca tcgggcattg cagtcacgtt gcgcaccgct
268801 cgctatcccg gtgcgccacg gcatgaactg gtcgacgggg tgcggatcag tcgtgccggc
268861 gggcgctact cggtgtatct atgggcgttg ctggcgatgg ccgcagcccg atgtgggctt
268921 gggccgctgc gccgagtgcg cccggatgtg gtcgtcgata cccaaaacgg ctggccgttt
268981 gtggcccggc tgttgtatgg ccggcggtcg ctggtactgg tacaccattg ccaccgtgag
269041 cagtggccgg tggccgggcg gatgatgggt cggctcggct ggtatgtcga gtcgatgttg
269101 tcgccacggc tacaccggcg caaccagtac gtgacggtgt cgctgccgtc ggcgcgggat
269161 ctgatcgccc tcggtgtgga cagcgagcgg atcgctgtgg tgcgcaacgg cctcgacgag
269221 gcgccgtcgc caacgttgtc cggcccacgt gcgcccacgc cgcgtgtggt ggtgctctcc
269281 cggctggtgc cgcacaagca gatcgaggac gcgttggcag cggtcgcgga gctacagcct
269341 cggataccgg gcctgcacct agacatcgtc ggcggtggct ggtggcggca gcgcctcgtt
269401 gaccatgtgc accggctcga cattgctgac gccgttacct ttcacgggca tgtcgacgat
269461 gtgaccaaac accatgtgct gcaaagctcc tgggtgcact tgttgccctc acgtaaagag
269521 ggatgggggc tcgcggtcat cgaggcggcc cagcacggcg tgcccaccat cgggtacaga
269581 tcctccggtg gtttggcgga ctcgatcgtc gacggggtga ccggcatatt ggtcgacgac
269641 cgggccgaat tggtggcttg gctcgaacaa ctgctgtccg attcggtgct gcgtgaccaa
269701 ctcggcgcca aggcacaggc gcgtagcggt gagttctcct ggcggcaaag cgccgaagcg
269761 ctgcgcagcg tgttggaggc agtgcaggcc agccgttttg tcagcggcgt ggtttgagcc
269821 ggcttcgaca gacttaatcc tgggcgcggc tcgccggcgt gtcttcgcag tggtgtaagt
269881 gtcggcgcac ccaatagccg gccgcgccag cgccgccgac cagcagcatc gaaagccacg
269941 cccaatgcgc gagcattgtc gctttgaggc gggccgacga tgcaccggag gtttggccgc
270001 cgacccgata aagagccaat tcgtcgtcgc ggtgcgccgc tgctagccgg ccgagggtgc
270061 gtgcggccgc gcccatgtcg ccggcgctgt cggattcgac gaccagccac ccgacgccgg
270121 ccgcggccaa ggttgacgga tggggcccgg tgagcagcag ctcctggacc gcccgggcgt
270181 gcgcgtcttc gccgggaacg gtcaccccgg aaatgaccag atcacctgtg gtcagcacat
270241 cggcgcgaac ccaacggggg agcggatcga gtaccggtgc cgaaccggac cacgagaagc
270301 gccgcatggt gcccgcgggc aagaccgcaa ccgtccgggg atcggcattg atcgccgctg
270361 ccaccgccgc ccaaccggac gggtagtgca caggcgcaac cttgccccac accccccacg
270421 ccaagtcagg cagcgttagg accagcgcca gacagcagac caccgccgcc gttgccggtc
270481 gcagccagcg tcgcagcgtt agcaccgtgc ccgcaccgga gagtgtgtat ccgggtaccg
270541 ccagcgcgac ccacttctgt ccgtcgcgca gcacgcccag gccgggtgcg gcatcgacca
270601 ccacccgtag cgcgtgcaga cctgggccgg tcgcaaggac agccgggacc atcacggaca
270661 ccgccgctag tgtcagcagc ggcactgcca cgggccggcg cgccacagtc ggtagtccga
270721 tcgccaccat ggcgagtagt acgacggcgg atgccactgc gaaaagcgtt gtccgcgagc
270781 taggtacggc ctcgccgttc cagatcccac cgagactggc caagctgcca agcgtgccca
270841 gccccggttc ggcgcgtggc gcgaacgcgg taaccccaag ctgattggct gccgtgtggc
270901 tggtcaacga cgagcccagc gccgacgccg tcagccaggg cagcgcaccc accagcgcgg
270961 agcccaacgc cgcgacccca cattgccagc gcgggcggcc cgcgccgggc atcgccacgc
271021 acaccaccgc aactgtcgcg gcgagtagca gcccggacgg ggtcaggccg gccagcgcaa
271081 cccagaacgc cagcccaaaa agcccgaacc aacccgcgcc aaccgttgtt cgcatcgtta
271141 acatcgcggt cgcaacccag ggcagacacc catagccgac cagcaggctc caatggccct
271201 gcaaaagtcg ttcggccaca tagggattcc agatcgccag cgtgatcgcg acaaactggc
271261 cggctgcccc cgctgcgggt agtgccgttg cgaccagtcg ggccgcgccc cagcccgcca
271321 gccaaagccc cagcagcagc agcgctttca ccacgacgcc gccgtcgacg aggtgtgacg
271381 ccaaagcgac cgcgaagtcc tgcggagtcg cccggggcgc cgatgtcagc cctagggcgt
271441 tggccgacac atacgaccgt ggtgtggaca ctgcatcgcg cagcagtagg tatccgggcc
271501 gcagtagcgg cgcggccaac agcagcacca agaccagcgc gtaccccggt cggaaccagc
271561 gcacgtcgcc tgattagcgc cgctcgggcg ggccggggtc gggatgcccc gcgtccggcg
271621 gtgggggcgg ctgcgccgaa ccgagtcggg gcggatccga gccactcggc tcgcgcggga
271681 agtcggggcg ctgcgtgggc agtttctcgg tctcagcctc cgctccaggc accggttctt
271741 cgaagccgcc gcggcggtaa tcgtggtcgt cccgatcccc gctggcagcc atcagcgcac
271801 cttcggtccg aaggctaaac gacgcgaaca gaccaccgcc gaccagcgcg accaagccgg
271861 ccgcggtgaa tgtaatcggc agcacccgcg accacagcgc cagccggtcg cgctcgtcgc
271921 gagccgcgtt gacctgggat tcgaccgtct cttcggtgga ggtgacctgg tagtcggcaa
271981 acgtgacctc tggtttgagt gggtcacgag cgaagtagtg gttggcgcgt tcggtttctt
272041 tgacgatggt gccggacacc gggtccaccc agaatgttcg ctgcgccgcg taatagcggg
272101 tcatggtgat ttgctcgttc ggatcaccgg gtagccccca catcgccgct gatgtggtga
272161 ctttgccgtc ctcgtcgccg gcgtacagcg acgggtattt gaggggagcc accagcttcc
272221 cctcgggggt gtagccgacg ttctgcgtga agcggtatgt ggttaaaccg ttgacgtcct
272281 cctcgccttc gtagttggcg tcaaacgcct tctgtgcgat ggggtcgaaa taggggtatg
272341 tcttcttctc ggtgtgaaac gggaaccggt aagacagccc gtcgtgccgc agcggaatgg
272401 ccgtcggcgg gttctcgtca ttgaggcccc gcggtttctg gacggcgccg ccggtgtggg
272461 tgtcgtcgga gacagccatc gccgtcttgc ggttgagggt gaccgtgtcg acgatcgcca
272521 gcagcagccc gctgtccttc tgcttgtcgg tgcgccggag cgaggatccg acctgaagtg
272581 tgaccacgtc ggcgttggcg ggcgattcga cggtgacttg ctgttgggac accagcggca
272641 cgtcctggtt gaccacgatg tgctcggtgg ctagcgacgc cgagtcgagt gccgttccag
272701 tgccgtcgct gatcaacgtg gcatcgatat cgagtgggat ctcagcgatc ctgctggtgg
272761 tataggtcga cagcagcagg gcggcgatca gtagggcggc tccgagtccg atagcgccgc
272821 acgcggcgaa ccgcaacatg actgcccggt tcacctgcgc cgctctcccc cgcaagcggg
272881 tggtgccccc acctcatcgc ttcgtccccc gcaagcgggc ggtgccccca ctgcatcgtc
272941 gccggcgcgg ttcacgttgc tgtgacctcc ttatggtcca tggactcgtc ggtcgggacc
273001 cgctccgacc tgaccaagcg aggcaaaacc cgtttgaccc taacagcaga gcgtatgggc
273061 ccggcggacg aatcgggtgc accgattcgc ccgcaaacac ctcacaggca cactgtgttg
273121 gtgaccaacg gccaggtggt gggtgggacc cgtggctttc tgcccgccgt cgagggaatg
273181 cgcgcatgcg cggccgtcgg cgtcgtggtc actcacgtcg cgttccagac cgggcactct
273241 agcggtgtgg gcgggcggct gttcggccgc ttcgatctgg cggtggcggt gttcttcgcc
273301 gtgtcgggat tcttgttgtg gcgcggacac gccgcagcgg cgcgagatct gcggtcacac
273361 ccgcgaaccg gtccgtatct gcgatcgcgg gtggcgcgca tcatgccggc ctatgtggtg
273421 gcggtggtcg tcatcctgtc cctgctgccc gacgcggatc atgccagcct gaccgtgtgg
273481 ctggccaacc tgacgctcac ccagatctat gtgccgctga ccctgaccgg cggcctgacc
273541 cagatgtgga gcctgtccgt ggaggtcgcc ttctatgcgg cgctgccggt cttagcgttg
273601 ctgggccgcc gaattccggt cggtgcccga gtgccggcga tcgcggcgct ggcggcgctc
273661 agctgggcgt ggggctggct cccgttggac gccgggtcgg ggatcaaccc gttgacctgg
273721 ccgccggcgt tcttctcgtg gttcgccgcg ggaatgttgc tggcggagtg ggcctacagc
273781 ccggtcgggt tgccgcatcg gtgggcgcgc cgccgcgtgg cgatggcggt taccgcgctg
273841 ctgggttacc tggtggcggc ctcgccgttg gcgggtccgg agggcctggt tccgggcacg
273901 gcggcacaat tcgcggtgaa gaccgcgatg ggctcgctgg tagcgttcgc gctggtggcg
273961 ccgctggtgc tggaccggcc cgacacgtcg caccggctgc tgggcagccc cgcgatggtg
274021 accctgggcc gttggtccta tggcctgttc atctggcatc tggccgcgct ggccatggtg
274081 tttcccgtga tcggagcgtt cccgtttacc gggcgaatgc cgacggtgct ggtgttgacg
274141 ctgatcttcg gtttcgcgat cgccgcggtc agctacgccc tggtcgagtc gccctgccgg
274201 gaagcgttgc gccgctggga gcgccgcaac gaacccatat cggtcggcga acttcaggcg
274261 gacgcgattg caccctgact cggccggctg acacctggcg ggcacctagt cgatcgtgcc
274321 cgctggcacg atccactgac agggctgacc ggtcacggcg gcgatgagat cgaagtccgc
274381 gtcgtaatgt agaacgacca gcccgtgttc ctcgccggcc gcggcaatga gcaggtccgg
274441 gattttgcga ccgcgctgac tacgcgcagc gagtaggcgc tggattccaa gcgcgcggcg
274501 atgatgcgat gccgtcgatt cgatgaggtc gaacgcgctc aatgccacca tgagccgctg
274561 ccactcggtc tcattgcgtg cggagtaccc gacttcaagg tcggttattt gcgtgcgagc
274621 gacggcaccg gcctcagcca acggttccac cgcccgccgc acggcgggcc ggctgagcct
274681 tttgatcacg ctggtgtcga gaagatattt cagcgccatg cttcggcgcg gtcctctggc
274741 ggtgcggcgg ccagcgtgtc gagagcggcg gcgacgcgtt gaactcgctg agacgtggct
274801 tgccgcaggg ccgcgttgac ggtgtctttg atcgtcgtcg tgcccaattc tgtacgagcc
274861 atgtttaaag cctgctcgtc gatgtcgacg agatgtttcg ccatgaatcg gagtatatat
274921 caataaggag ccgatatata tgcacaatgc caagcccatg gcattcgccc ggcgcggctg
274981 tctcactgat agccgccctg ccgctcgaag atgcggcgcg ggttgtcgac gagcatggtg
275041 tgcagctgct cgtcggtgac gccgtgctgc ttcagtgcgg ggatgacgtc gttgtggatg
275101 tggaggtaat gccaattcgg catcgccacc ggcaccagct cctcgggaag cgcgtcgaaa
275161 tagcagcagg cgtcgtgtga tagcaccatc ttgtcggcat ggccgcgctc gcacattcgg
275221 gccacgatgt tcacccggtc ctgaaacggt gagatcacgt cgacgccgaa ccggtccatc
275281 ccgaggtagg agccggcggc gatgagctct tccaggtagc cgacgtcggt gctgtcgccg
275341 cagtgtccga taaccacccg gctcaggtcc accccctcct cggcgaagat gcgttgctgg
275401 tcaaggccgc gccgcagccc ggcgtgggtg tgggtggaga tcggcgcccc ggtgcgtttg
275461 tgtgcttggg cgaccgcgcg caacacccgc tcgacaccag gggtgaggcc gggttcgtcg
275521 gtggcgcact tgaggattcc cgccttgatg ccggtgtcgg cgatgccgtg ctcgatgtcg
275581 cggacgaaca tgtcggtcat gatctccggg ccgtccagct gtgcgcccgg cccgaggtag
275641 tggaagtaga acgggacgtc gttgtaggtg tacaagccgg tggccacgac gatgttcagc
275701 tcggtggccg cggccacccg ggcgatgcgc gggatgtatc ggcccagccc gatcaccgtg
275761 aggtcgacga tggtgtccac gccgcgggcc ttgagttcgc ctagccgggc gatggcgccg
275821 gccacccgct tgtcctcgtc gccccaggct tccgggtagt tctgcgcaat ctcggtggtc
275881 atgatgaaga cgtgctcgtg catcagcgtg acgccgagat cagcggtgtc gatgggtccg
275941 cgagcggtat ttagttctgg cacgtcactg atgctaggcc gcaatcggtg tcttgcgggg
276001 ccgcagtgca gtagcgtcac cctcgtcgtt gaccgaaccg ctcgggagcc aattcttatg
276061 ctgctcaacc ccaaccattt gacacgcaaa tacccagacc gtcgctccgg ggagatcatg
276121 gccgcgacgg tggacttctt cgagtccagg gggaaggccc ggctcaagca cgacgaccac
276181 gagcggatct ggtactcgga cttcctggac ttcgtcgggc gggaacgcat ctttgcttcc
276241 ctactgacgc cggcctccta tggcgccgat gattgccgct gggacaccta ccggatcagc
276301 gagttcgccg agatcatggg cttctacggg ctgagctact ggtacccctt ccaggtgacc
276361 gccctaggcc tgggcccgat ctggatgagc gccaacgagg acgccaagcg caaggccgcc
276421 gcggggctcg aggccggcga agtgttcgcc ttcggcctgt ccgaacagac ccacggcgcc
276481 gacgtctatc agaccgacat gatccttacc cccagcgacg gcggctggac cgccaacggc
276541 gagaagtact acatcggcaa cgccaacgtg gcccggatgg tctccacctt cggcaagatc
276601 gccggcaccc cagaaagcca ggagtacgtc ttcttcgtcg ccgactccca gcacgagcgg
276661 tatgacctga tcaagaatgt ggtgaactcg cagaactatg tggccaatta cgcgctgcgc
276721 gattacccgg tcaccgaggc cgacatcctg catcgtggcg ccgaagcctt ccacgccgcc
276781 ctcaacacgg tcaacgtctg caagtacaac ctgggttggg gtgccatcgg aatgtgcacc
276841 cacgccctct acgagtcggt cacccacgcg gccaaccgtc acctgtacgg cactgtggtg
276901 accgacttca gccacgtgcg gcggctgctc accgacgcct acgtgcggct aattgcgatg
276961 aagctggtcg ccagccgggc cagcgactac atgcgcagcg cgtcggccgc cgaccgtcgc
277021 tacctgctct acagcccgct gaccaaggcg aaggtcacca gcgaaggcga gcgggtcatc
277081 accgccctgt gggacgtcat tgcggccaaa ggggtggaaa aggacacgtt tttcgagacc
277141 gtggctcgcg agattggcct gctgcccagg ttggaaggca ccgtgcacat caacatcggg
277201 ctactcggca aattcatgcc caactacctg ttcgctcccg actccacgct gccggtcatc
277261 ccgcgtcgcg acgacgccgc cgatgacgcg ttcctgtttg cccagggacc caccgggggc
277321 ttgggtaagg tgcgtttcca cgactggcgc gcgtcatttg acacctgcgc gcatctgcct
277381 aatgtcgcac tgctgcgcga gcaagtcgac gtgttcgccg agctgctggc cagcgccacc
277441 ccggacgcgg cacagcagaa ggatatcgac tttgccttcg gcgtgggaca actcttcgcg
277501 aacgtgccct atgcccagct cattttggag gaggcccggc tatctggtgt cgacgaggcc
277561 ttgatcgacg agatcttcgg cgtactggtt cgggacttca acacccatgc cgtcgagctg
277621 cacggcaggt ccgccacgac agccgaacag gctcggttcg ccatgcgaat ggtccgtcgg
277681 ccggtgcacg atcccgcccg ctacgaccag atctggaagg accacgtgct cgcgctcaac
277741 ggcgcatatc aaatggcacc atagtgcgcc gcgtcgagat cgacgctgcc gtgttgccca
277801 ctcgcacttt cgcgcgctgg tgtcaatctc gacgccagcc ttgaccgtga tgcagcgcac
277861 agtagaatga ccagtggtca ccaacgcaag gaggccccat gccgacggtg acgtgggcgc
277921 gtgtcgatcc ggctcgccgt gccgccgtgg tggaagccgc cgaggctgag ttcggtgcgc
277981 acggattctc ccgcggcagc ttgaacgtca tagcccggcg tgccggagtc gccaagggca
278041 gcctgttcca gtacttcgcg gacaagcgcg acctctacgc gtttattgcc gacatcgcca
278101 gccagcgagt ccgctcctac atggaggacc tgatccgcga gctggacccg aaccggccgt
278161 tcttcgaatt cctcaccgac ctgctcgatg gctgggtcgc ctacttcgcc gagcatcctc
278221 gggaacgtgc gttgcatgct gcggcgaccc tggaggtcga caccgatgcc cgcatcagcg
278281 tgcgcagcgt cctgcaccgc cactacctgg acgtgctacg gccgctggtg cgcgacgcgc
278341 acgcgcgggg cgacctgcgc gcagattccg acaccggtgc attgatgtcg ctgctgctgc
278401 tgatctttcc gcacctggcg ctggctccat acatgcgtgg tttggatccg atcctgggcc
278461 tcgacgagcc cacacctgag cagcccgcgc tggccgtgcg caggcttgtc gccgtgctgg
278521 cggcggcctt cgatgcccag caccccgcga ccaactcagc ccagacccga tcggaggaga
278581 tcacatgaca cgcacacgtt cgggctcgct cgccgcgggc ggactcaact gggcgagcct
278641 gccactgaag ctgttcgccg ggggcaacgc aaagttctgg catccggccg acatcgactt
278701 cacgcgcgac cgggcggact gggagaagtt gtcggacgac gaacgtgact acgccacccg
278761 attgtgcacc cagttcattg ccggcgagga ggcggtgacc gaggacatcc agccgttcat
278821 gtccgcgatg cgggccgagg gacggctggc cgacgagatg tatctgacgc agttcgcgtt
278881 cgaggaagcc aaacacaccc aggtgtttcg catgtggctg gatgccgtcg gaatcagcga
278941 agacttgcat cgctatctcg acgacttgcc cgcctaccgc caaatcttct acgcggagtt
279001 gccggagtgc ctcaacgcat tgtcggccga tccctcaccg gccgcccagg tccgggcgtc
279061 ggtcacctac aaccacatcg tggaaggcat gctggcgctc acgggctact acgcctggca
279121 caagatctgt gtggaacgcg caatccttcc cggcatgcag gagctggtcc ggcgcatcgg
279181 tgacgacgag cgacgccaca tggcttgggg caccttcacc tgtcggcgcc acgtcgccgc
279241 cgacgacgcc aattggacgg tgttcgaaac acggatgaac gagctcatcc cgctggcgct
279301 gcgcctcatc gaggagggct ttgcgctgta cggcgaccag cccccattcg acctgtccaa
279361 ggacgatttc ctgcaatact cgaccgacaa gggaatgcgc cggttcggca ccatcagcaa
279421 cgcccgcggc cggccggtcg ccgaaatcga cgtcgactac tcgcccgcgc agctggagga
279481 caccttcgcc gacgaggacc ggcgcaccct ggcagcggcc tcggcctagg cctggcgagc
279541 agacgcaaaa tcgcccaatt tcgtgccgaa ttgggcgatt ttgcgtctgc tcgccagggg
279601 aacgctaggc gatccagacg gtcttgatgt tgcagaactc gcgtatcccg tgtgcggaca
279661 gttcccggcc atagcccgag cgcttgaccc cgccgaacgg caattcggga taggacaccg
279721 tcatgccgtt gataaaaacc tggcccgcca cgatgtcgtc gatgaagcgt cgttgctcgg
279781 tctcgtcgcg ggtccaggcg ttggatccca gcccgaaggt ggtggcgttg gcgatctcga
279841 cggcctcgtc gatgttcgcc gcgcggaaca ccgaggcgac cggaccgaag acctcctcgg
279901 tgtagagagc catgtccttg gagatgtcgg tgatcacggt cggcgggtag aaccagcccg
279961 gccggtcgag acgctttccg ccgcaccgga tcaccgcgcc cgccgcggca gcatcctcga
280021 cttgcttggc aacctcgttg cggccctgct cggtggccag cgggcccacg tcggtgtccg
280081 ggtcggtcgg gtcgccgacc cgtaacgccg ccatccgcgc gacgaacttg tcgacgaaat
280141 cgtcgtaaat gtcggcgtgg acgatgaacc gcttggcggc gatgcaggat tggccgttgt
280201 tctgcacccg gccggtgacg gcggtgctga ccgcggcgtc cagatcggcc gacggcataa
280261 cgatgaacgg gtcgctgccg ccgagctcga gcacggtcgg cttgatctcg ttaccggcga
280321 tagcgcccac cgattggccg gccggctcgc ttccggtcag cgtggccgcc gcgacccggg
280381 gatcacgcag gatggcttcg acggctcccg agctaacaag caacgtctgg aagcagccgt
280441 ccgggaagcc gcctcgggcg atgacgtcgg ccaggtacag cgcgcattgc ggcacgttcg
280501 acgcgtgctt gagcaggccg acgtttccgg ccatcagtgc cggtgcggcg aaccgaaccg
280561 cttgccacag ggggaagttc catggcatca ccgccaggat caccccgagc ggctggtatc
280621 ggccgtaggc cgccgacgcc ccgaccttgg ccgcatcggc gggttcgtcg gccagcaacg
280681 cctcggcgtt ttcggcgtag tagcgaaaac ccttggcgca cttcagtgcc tcggctttgg
280741 ccgcggccag cgtcttgccc atctcgagcg tcatcatcgc ggcggcctgg tcggcctcgg
280801 cttccagcaa gtcggcggtg gcattggccc accgggcgcg ctgggcgaag ctggtctggc
280861 ggtagtcggc gaaccgccgg tgggcccggg ctattgccgc gtcgacttcg tcatcggtcg
280921 ccgcagtgaa tgtcttgact gtttcgccgg tagccgggtt gatggtggcg atgggcacgc
280981 tgacatcctt tgctgggtgg gtttgcacaa atcgtccggt gtccagcctg ccactaacgt
281041 ggccagcgct cccgagcagg aggtgtcggg gcctcctatc ggctggggtg ggctctatca
281101 cgggcaggac cagcgtggcg gaacatgtca ccgatcgcat gttcgtcggg agctaatcgg
281161 cccgttcaat cggccggtgg cgaggcgact ttgcgtagcg acatcggcgg gacgtagcgc
281221 ccgatcagcg tgcggtgcca ccaggctcgg tcccgtcgca gctcggccac ggtggtgaag
281281 cggtactgat acagctgcgc gcgcacatac cgaggcggag attgcgggaa aggattgtgg
281341 cgcaacagct tcagcgtcgc aggatcattg cgcagcaacc ggtttaggaa tggcgtcatc
281401 cacggtagtg cgtagcccgg tgagatggcg gcgaaccaca tgagccagtc cagccgcaga
281461 tggtaggggg cccattgccg cggcagccgg cgcggatcac cgggcttgcc cttgaattcg
281521 tatgctttcc agacggtttg ttcggtaatc ggtgactcgt cggtcccttc gattaccact
281581 tcccggcggg tgcggcagat gctgccgaac gccccgtagg tgttgaccaa atgaaagggg
281641 ttgaacgaca tgttcattcg ttgatgagag gacagcagat tgcgtgccgg ccagtagctc
281701 agcaacagca ccgccgcggt gaatacgacc acgaggccgg cgaaccactg cggcggtgcc
281761 gacagcgccg gctgggccgg catcggcagc agcgccgcgg ccgaagatgt gtcgatcgcg
281821 ctgcacgcca agaggatggt cagccaattg agccaggaga aatttcccga tgccaccagc
281881 catagctggg taaccacgat gatcgcggcg gcgatgctgg ctgcgggctg tggtgtgaac
281941 aacccaaacg gcaccacgag ctgggcgaaa tggttgcccg ccacctcaat ccggtgcaat
282001 ggcttaggca ggtgatggaa gaaccagctc aacgggcccg gcatgggctg tgtttcgtgg
282061 tggtagtaca ggcacgtcag actgcgccag cacgagtcgc cgcgcatctt gatcaatccg
282121 gcaccgaatt cgacccggaa cagcagccag cgcgccaaca acaacgtcag aatcggcggg
282181 gcggtgcgct cgtttccgag gaagatcatc aggaagccgg tctccagcag cagcgactcc
282241 caaccgaatg agtaccacgc ctgcccgacg ttgacgatgg acaggtagag cacccacagc
282301 gtcagccaga tcagcatcgt ggcccacaac ggcacgaagg aggccgcacc ggcgacgacg
282361 gctgccgaca acacggcacc caaccagcag accccggcga acacccgatc ggaatagcga
282421 aagtgaaaga tgctcggtgt tcgccagaag gactgtccag ccagataccg cggcaccggc
282481 agcatgccgt gctctccgat gaggggccgg aactgctgtg cggccgcgac gaatgcgatc
282541 agataaataa tcgccgtgcc gcgctccagc gccagtctgc ccagccaata ttcgggcgct
282601 gaaaaccatc ccatggccgt tactccttgg acacggcgtt cacaccaact attgcatgcg
282661 gtcttgacca cgagactctg atgtggcgac caccgatgcc gccaccacgg aaaccgaaat
282721 cagtgccagc agttgcacac tggcccagtt cccggcgtat ccgtcgaccg accgccacgg
282781 atgccgggac agcgcagcgc cggccaggat cagcccgccc gcagccagtc cgacggtgac
282841 ccggtcacgt agtcgctccc ggcggcgcag tgcataccgc acaccgaggg ccgtgcccat
282901 caccatgacc ccggcgatgc tggcgatcac cgccccggcc gccagcaccc cggccgccgc
282961 ccaggctccg ggcctccagg gtggtgtggg ccggtcggcg agctgccgtc gcccggtccg
283021 ccagaacgcc agcagagcta gcaggggcag cagggccagc cctatcgcca ggctcgcccg
283081 atacagcgag ttcggtgcga atgtcagcgt gatggtgccg gggttcccgg cgggcaccac
283141 ccaggcctgc tgccacccgt tgacggcgat cggtgtcagc cgggccccgg tgctcgtgcg
283201 ggccacccag cccgagttga tgctttcggg taccaccagc acccgggaag tggccgactc
283261 gggaacccga acttcgcggt gggtgggacc ccacgcaccc gtttcagcag aagtaactgt
283321 cgcgcttgac aatccagcac cgggagttga caactgggca ccgtcgacca cgaacgcggc
283381 gccggggctg atcagcaatt cctgctgtcc cgccggcagc gctatcggct cgcgttcaca
283441 cgggagcgcg gcgaccggtt caccgtccag caaggcgccc accgtggttc ggatcgaggt
283501 gtgcacgaac cggcccgcga cggcgacgac cgggccgtga tcgcaatcca cggtgagcgc
283561 acgcgcgcgg ttgcgggcgg cgtcggccgg cgcaatcggg gcgccgccgg cgctaagcac
283621 caccacttcg gccagccccg gcggcttgag ctggtcgaag cccagcgcgt tgcgatcgat
283681 gacatcgtcc cagtccagca ggctgaccga caccgtgtcg gtcacccggg gatgcagcca
283741 tagcgtcgtt agctcgccga cctgcagttg tcggacctgg gggccgtcgc ccaggttgat
283801 ggccaccacc gtcggatggg ccggcaacat cgaccggctg gcggccagcc gcagcccggt
283861 caccacggtg ggccgcggca gggtcagcgt cagcgtcggc ggggttttgt gttgcaccac
283921 ccgctgcggc gcggtccagg cggtggccgg atcgccgtcg gcggccgcgt acgccgagcc
283981 gaggatgtcg acaaggtcgg aatcaccgct ggcccgggtg gtggaaggcg cggcgatcaa
284041 gtcggccagc ttcgggccct gccgtggtcg cacccacacc atcggggtca ccgacaccgg
284101 gcggggtacg gtcagtgtgc ggctgagatt ggccggttcc tcgggtgcca gggccatcga
284161 ggcggcgcag cgcacgccgt cgggtcccgg ggcgcagccc ggtctgccca gcagttcgga
284221 tcccaggtcc cagcccgcga tcgccgaacc cggcggcggc ccgggcacca gcacggtgtg
284281 tcgcagctga accggatggg cgaaaccgga cgcatcgtat tgggtgatgg ccagatcggt
284341 gatgccgaac tgcacaccgg ccgacccgtc gtcggtggcg gccgcggtaa accgcaccca
284401 gggggtttcg ccgtagggca gtgcggcggt gagcggtttg cccgcctcat cgaaccgcag
284461 ggtggtgctg ccgttgacgg tctcgatcag gatgcgtcgg acctgggcgc cgaccgcggt
284521 cgcgctgggt gtcagggtga cgacggcatt ggtcaccgga cggtcgaaat ccacctgcag
284581 ccactgccca acggcggcct gcagcgcgtt ggacacccaa gcggtcgccg ggtcaccgtc
284641 gacggcggcc gcgggtgcgc tcgccggggc gacgtcgggc atggcggtgg catccgccga
284701 ggagctcgac acggtgatcc ggccgccggt ccatccaccg acgaccggct ccgcgcccgg
284761 caccgggtag tcaggcaccc ggttgtaggt gtgccgggcg tcgccgggtg cccggatcgc
284821 cgacgagtgg tggtccaccc ggccgtaatc ggtctcgcgg gccaccgggg tgtcggtgac
284881 ggcgacctgg ggcaccggca agccggcagc tcgagcgtcc gcggtcatca gcaccggacc
284941 cagcgggggc tggccctgca gccggcgtcg ttcgtccaga cgcagcagga cctcgggtcc
285001 gccgtcgacg cgggcgagct ggtcggtcgc ggcgaagtag ggcgcaccgg ggttggcggg
285061 cgcgctcacc cggtagatct caatcgcggg atatcggggt cgcaggccgc tgtcgttgac
285121 gaaacccgcc agcggatcag gacccaccgg cgcgccgaac tccgccagct tcgctagccc
285181 gggcgaccct gcgatgctac ggtgcagcag aatcggtcgt gccgagcgcg acgtctcggg
285241 atccagatcg ttgcgtacca gcacatagga aatgccttgg cgggcaaggg tatcggccag
285301 ccccgccgac ggtcgtccgg cggcgaacag gcgttgcacg gagtccagcg ctcgaatggt
285361 ctgcggcggg gtcagcggaa tggagtcgcg cacgccccac gggccgtcgc cgagcacctg
285421 cagcggctcg tcgtggctgg tgccccacac ctgggtggcg aacggggcgc ccgggaccac
285481 cagcacccgc ccgggagtgg gcgtcgcggc atggtgtgtg cgcagccagt cggcggcctc
285541 ctgccagtac tggggaagcg caccgaacgt gccgggcggg gcgacccggc cggtccacgc
285601 cagcgaggtg ctgaccatca gcgcggtcag ggctaccacc gccaccgcta ctcgcttgtc
285661 ccgctcgggg tgcgcgaacg cgcgcagcca cgccggcctc ggcgcgctgc ctggcagcgg
285721 aactcggctc agcagctgcg ccaagcccag caccaggggc agccggatca caggccccac
285781 cttgtgtacg ttgcgcaggg gggtgccggc ggcgtccagg aacgcctgca ccgggtgggc
285841 gaccggcgaa gccagcccgc cgcggtggcc aacggccagc agcaccaccc cgaccaacag
285901 catcgtcacc agccggccgc gcgccggcat cgccgggcta gtcagtccgg ccagcccggc
285961 cgctgcgacc aggcaggtgc ccaggatggc cgccgatccg gtgaccaacg gcgcgcccgc
286021 ggtcgcgttc ggcgccacga acggcgtcca gctgtcggtg ccgcgcagca cctccaccag
286081 cgaggaccat tgcgtggtca cgccggaaga ttcgatgaag tccagaaacg gcggactgac
286141 cccgtgcagc tgcgtcagcg ccattaccca ccacagtgtc gccagggcca tcgccaacag
286201 ccaccacgcg gtgtagcgcc accacaaccg attcggccgg tgacaggccc accagatcac
286261 cgccggcagg caaccggcca gcgtcgcgat ggcgttgacc gcgcccatca gcgccaccgc
286321 cagcccggct tgggcggcca gcgcgcgcac cgagcggcca gaagtccccc gcagcgccag
286381 gatcgtgggc agcagcaccc acggcgccag catcatcggc aaggtttccg acgagatcga
286441 cccgagtgtg gtcagcaccc gtggtgacag cgcgaacgcc acggcgccga ccacccgcga
286501 ggacgggccg ccgacgccca gcgcctcggc tacccgcagc aggccccaga agccgaccgt
286561 gagcaacacc gcccaccaca gccgctgagt gacccagccg ggcactccca gcaggtgacc
286621 gatcacgaag aaggtgccgt gcggaaacag atacccgtag gcctggttct gcgcctgccc
286681 gaacggcagg tcgctgttcc acaggttggt cgcacgcgcc aggaagcgca gcgggttggc
286741 ggtgaggtcc agcttggtgt cgggggagac ttgtccgggg gattgggcga acgtcagcgc
286801 caacgctacc gcgccgacca ccggcagcca tttgcgagac aacggcgcca cctgcgaccc
286861 ggaggccgcc tcagcctgcg gcgcccgggt cgcggggcta gctacggtta ccgtactcga
286921 cccggttgag cactgatgac gacggatcgc ccccggggag tggcggtttc ttgtcctgct
286981 gcaccatcag ggtcactccg aagatcgcgg ccgcgcccag caacagacca accaccacgc
287041 ttgcggcggc gggcgcgacg atccggttca tcggtggctc ctcgacggct gtgggtgcgg
287101 cttgagaggc tagaggcaac ttagcagaag cgtgggcctg gccccccaac ccggagcgta
287161 tgcgccaccg tgacagcatg tccggatggc ttttccacgc acactggcga tactcgctgc
287221 ggcagcagcg ttggtggtgg cctgcagcca tggcggcaca cccaccggat cgtcgacgac
287281 ctccggcgcg tcgcccgcaa ctccggtagc cgttcccgtg ccccggagct gcgccgagcc
287341 ggcggggatc ccggcgctgc tgtccccccg tgacaagctg gcccagctgc tggtggtcgg
287401 cgtgcgagat gctgcggacg cccaagccgt ggtcaccaac taccacgtcg gcggcatcct
287461 catcggcagc gacaccgacc tgacgatttt tgacggcgcg ctggccgaga tcgttgccgg
287521 cgggggtccg ctgccgctgg cggtgagtgt cgacgaggaa ggcgggcggg tgtcccggtt
287581 gaggtcgctg atcggcggta cggggccgtc ggcccgcgaa ctggcacaaa cccgaaccgt
287641 ccagcaggtg cgcgacttgg ctcgagaccg cggccggcag atgagaaagc tgggtatcac
287701 catcgacttc gccccggtgg tcgacgtcac cgacgccccg gatgacacgg tgatcgggga
287761 ccggtcgttc ggctcggatc cggctacggt caccgcgtat gccggggcgt acgcgcaggg
287821 tctgcgcgat gccggggtgc tgccggtgct caagcatttc cccggtcacg ggcgtggctc
287881 gggtgattcg cacaacgggg gtgtcacgac accaccgctt gatgacctgg tgggcgatga
287941 cctggtgccc taccgaacgc tggtgaccca ggcgccggtc ggtgtgatgg tgggtcatct
288001 gcaggttcct gggttgaccg gctccgagcc ggccagtctg agcaaggccg cggtgaacct
288061 gctgcgcacc ggcacgggat acggcgcacc gccgttcgat ggtccagtgt tcagcgacga
288121 cctctctggt atggccgcga tctcagaccg gtttggcgtc agcgaggcgg tgttgcgcac
288181 cttgcaagcc ggtgccgata tcgcactgtg ggttaccacc aaagaggtgc ccgcggtgct
288241 ggaccgcctg gaacaggcgc tgcgcgccgg tgaattgccg atgtcggcgg tcgaccggtc
288301 ggtggtgcgg gtggcgacca tgaaggggcc caacccgggg tgtggccgtt agcgatgtgc
288361 ggctggcgcc ccactgctta ccgtagggtt agatagacgg gctacagggg cccaaaaggg
288421 gctggcgatg gcaggtggta ccaagcgact accgcgtgct gtccgagagc agcagatgct
288481 cgatgccgcc gtgcagatgt tctcggttaa cggctaccac gagacctcga tggacgcgat
288541 cgctgccgag gcgcagatct ccaagccgat gctgtacctg tactacggct ccaaggaaga
288601 cctgttcggc gcctgcctga accgtgagat gagccggttc atcgacgcgt tgcgttccag
288661 catcaacttc gaccagagcc cgaaagactt gctgcgcaac accatcgtgt cgttcctacg
288721 ctatatcgat gccaaccggg cgtcgtggat cgtgatgtac acccaggcca ccagctccca
288781 agcgttcgcg cacacggtgc gtgaggggcg cgaacagatc gtccaactgg tggccgagtt
288841 ggtgcgggcc ggcacccgcg gcccgcttac ggacgccgaa atcgagatga tggccgtcgc
288901 gctggtgggc gccggcgagg cagtggccac ccggctcggt atcggtgaca ccgacgttga
288961 cgaggcggcc gagatgatga tcaacctgtt ctggctcggc ctcaagggcg cgccggtgga
289021 tcggctcgag accgggcact gacctgcgcg gtatcggcca ctgagatgtg ggtgtatttt
289081 agatgcagat gtaaattcga tgtatgattc gaacgcaagt ccagctccca gatgagcttt
289141 accgggacgc caagcgggtc gcgcacgagc acgaaatgac ccttgccgag gtcgttcgtc
289201 gcgggctgga gcacatggtg cggatctatc cgaggcgcga tgcggcgtcc gacacctggc
289261 agccgcccac gccgcgtcga ctcggtccgt ttcgtgcgtc cgaagaaacg tggcgcgagc
289321 tcgccaacga ggcgtgagta gcccgtgctc tcgatcgata cgaatatcct gctgtacgcg
289381 cagaaccggg attgccccga gcatgacgcc gccgccgcct tcctcgtcga gtgcgctggt
289441 cgagccgacg tcgcagtctg cgaactcgtg cttatggagc tgtatcaatt gctgcggaat
289501 cctacggtgg tgacgcgacc gctcgagggc cccgaggcgg cggaagtctg tcagacgttc
289561 cgtcgcaacc ggcggtgggc gctcctcgag aacgctccgg tcatgaacga ggtgtgggtg
289621 ttggcggcca cgcctagaat tgctcgccgg cgcctattcg atgcccggct ggcactgacc
289681 ttgcgccatc atggtgtcga cgaattcgcc actcgaaaca tcaacggctt caccgacttc
289741 ggcttctcac gcgtgtggga cccgataacg tcggatggct gaccacgccg ggccgatccg
289801 cgtggccccg gctatagacc ccgcacggta gcggtcaggt gggggtatcc cttggccata
289861 ttgcgcagcg tgagatccca gccgccatcg ccttcggcga cgtagagtcc cgcggtggcc
289921 ggcagcagca ccggcttggc gaaccgaacc gaatagcgca ccgcgtccgg aaaacgggct
289981 tcgatattcg ccaataccgc cgcggcagtg aacatcccgt gcgcgatgac ggtggggaag
290041 ccgaacagtt tcgccgcgat cgggttggtg tggatcgggt tgtgatcgcc gccgacggcg
290101 gcatagcggc ggatcttcgc cggggtgatc cgcaggaccg cggcgggcgg gggtagcttg
290161 ggcttttttt gcggcggcgg tttgggttcg ccggacaagc tggtgcgttg ttgatgcagg
290221 aacgtcgtca cctggtgcca ggcgacatcg ttgccgacgc tgacgttggt caccagatcg
290281 accagcaggc ccctgcggtg ttcgcgcaga ttctccgcgc gcacccgcac gcccaccgcg
290341 tcggtgaccg cgatcggccg gtattgcgtg atgtggttct cggtgtgtat cgctcccatt
290401 gcggcgaacg ggaagtcgaa gccggtcacc aacgacatca ccgatggaaa agtcaacgcg
290461 aacggatagg tcaacggcac ctggttgccg tagcgcagac cggtgaccgc cgcgtaggcc
290521 gcgacgttgg cggggtcgat cggcagctcc tcgacggtca ccgtccggtt gggcagctgg
290581 tctgtccggg gcaccacggg tagcgccccg gccgccgcgc gcagcaggtt cttcaggccg
290641 ctgggttgag tcactactgt cccctcacgc gccgatcatg gcctggccgc agacacgaat
290701 gacgttgccg gtcaccgcgt ttgacgccgg gctggcgaag taggcgatgg cctcggcgac
290761 gtcgacgggc tgcccgccct gcagcagcga gttcagccgg cggcctacct cacgggtggc
290821 cagcgggatg gcggccgtca tctgggtttc gatgaatccc ggtgccacgg cgttgatcgt
290881 gatgcctttc gcggccaggc cgggtgccag cgcctgggtg atgccgatca tcccggcctt
290941 ggtggtggcg tagttggtct ggccgcggtt gccggcgatg ccggcgatcg acgacagccc
291001 gatcacccga ccaccctctc cgatgctgcc gttgcccacc agaccctcgg tgagccgcaa
291061 cggggcaagc agattgacag ccaggacggc gtcccaacgc gcatcgtcca tgttggccag
291121 cagcttgtca cgggtgatgc cggcgttgtt gaccaggatg tcggccttgc caccgtggtg
291181 gtcgcgcagg tgctcgctga tcttgtcgac ggcatcgtcg gcggtgacgt cgagccacag
291241 cgcggtgccg cccaccttgc tggcggtttc ggccaggttc tcggcggcgg actccacatc
291301 gatggcgacc acgtgggcgc cgtcgcgagc gaacacctcg gcgatggttg cgccgatgcc
291361 gcgggccgcg ccggtcacaa tggcgacctt gccgtccagc ggcttctccc agtcggccgg
291421 cggtgtggaa tcgtccgccc cgacagagaa gacttggccg tcgacgtagg ccgacttggc
291481 cgacagcagg aatcgcatgg tcgactcgag gccggtagct gcgggcttgg cgtccggcga
291541 caggtagacc aacgccgttg tcgcaccgcg gcgcagttcc ttgcccagcg agcgggtgaa
291601 gccctccagc gcgcgctgcg cgatccgctc gttcgtgctg gcggccgctt cgggtgtgcc
291661 gccaacaacc accacgcgcc cgcaacggcc gagattgcgc agtaccggag taaagaactc
291721 gtgcagcccc ttgagcccgg ccggctctgt gatgccggtg gcgtcgaaga ccagcccgcc
291781 gaacgagtcc gcccagcgcc cgcccaggtt gtttcctacc aggtcgtagt ccttttcgag
291841 tgccgcgcgc agtggttcga cgaccctgcc ggccccgccg atcagcagcg acccggtcag
291901 tggcggttcg cctgctcgat agcggcgaag cgtctcgggt tgcggaacac ccaattgcct
291961 ggccaaaaac gatcctggac cggagttgac aacctgcgag aacagatcgg acgaacgctt
292021 gggagccact tcagctgcct tccgtatcgt gtgggggtcg ggcgcgccaa tacacgtaac
292081 cgtatcgagg actaacttac ttcagagtaa gaacagtggg tagtatggcc ctcaacggcc
292141 gatcccccga actgatcaac ggagaaaaca gtggcccctg ctgctaagaa cacttcacag
292201 accaggcggc gagtcgccgt actgggcggc aaccgcatcc cgttcgccag atcggacggt
292261 gcctacgcgg atgcgtccaa ccaggacatg ttcaccgcgg cgctgagcgg cttggtggac
292321 cgattcggac tcgccggcga gcggctggac atggtggtgg gcggtgcggt gctcaaacac
292381 agccgcgact tcaatctaat gcgcgaatgc gtgctgggct ccgaactctc gccgtacacg
292441 ccggcgttcg acctgcagca ggcctgcggg acgggcctgc aggccgcgat cgcggccgcc
292501 gacggcattg ccgccgggcg gtatgaggtg gccgccgctg gcggggtgga caccacctcg
292561 gacccgccga tcggcctggg cgacgacctg cgccgcaccc tgctcaagct gcgccgatct
292621 aggtccaacg tgcaacgcct caagctggtg ggcacgctgc cggccagcct gggcgtggag
292681 atccccgcca acagcgagcc gcgcaccggg ctgtcgatgg gcgagcacgc cgccgtcacc
292741 gccaagcaga tgggcatcaa acgcgtagac caggacgagc tggccgccgc cagccatcgc
292801 aatatggccg acgcctacga ccggggtttc ttcgacgacc tggtcagtcc gtttttaggg
292861 ctgtaccgag acgacaatct gcggcctaac tccagcgtcg agaaactggc cacgctgcgt
292921 ccggtcttcg gagtgaaggc cggtgacgcg acgatgacgg ccggcaattc gactccgctg
292981 accgacggcg cctcggtggc attgctggcc agcgaacagt gggcggaggc acactcgctg
293041 gctccgctgg cctatctcgt ggatgccgag accgccgcgg tcgactatgt caacggcaac
293101 gacggcctgt tgatggcgcc gacctacgcg gtaccccggc tgctggcccg taacgggttg
293161 agcctgcagg acttcgactt ctacgaaatc cacgaggcgt ttgcctccgt ggtgctcgcg
293221 catctggcgg cgtgggagtc cgaggagtac tgcaagcggc ggctgggcct ggacgccgcg
293281 ctggggtcga tcgatcggtc caagctcaac gtcaacgggt cgtcgttggc cgccgggcac
293341 cccttcgcgg cgaccggtgg gcggattttg gcgcagaccg ccaagcagct cgccgagaag
293401 aaggcggcga aaaaaggcgg cggaccgctg cgcgggctga tttcgatctg cgcggccggc
293461 ggccaaggtg tggccgcgat tttggaggcc tgacgctgac ggctcggtaa gtgcctcgcg
293521 ggaagtcccg agtggccggt gggccgccca aagaaatgtg ttgcgggtgg tttgcgccct
293581 gagcagatgg gtacccgatc actcggatag ccccgtgttg ttgtctgacc cccgaccccg
293641 acggcaatgc ggggcaatcc cctggaaagg gccgccgctg gtgggagggg acccagcggc
293701 ggtctttttg ggcttgcccc atcgttcgtt gactctgcgt ccaccacgca aaagtgcgag
293761 taacccgtcc ggtggacgca gagtcaacag ataaggatca gaacgcggcc tcgtcgagtt
293821 ccatgatgtc gttgtccagc gtctcgatca cctcgcgggt gctggtcaac agcggcaaga
293881 agttcttcgc gaagaacgac gccaccgcga ctttgccttc gtagaaggac cgctcgtcgc
293941 cggtggcacc cgcgtcgagt gccgccaccg ccaccgcggc ctgacgctgc agcaaccagc
294001 cgatgatgag gtcaccgacg ctcatcaaga agcgcaccga acccaagccc accttgtaga
294061 ggctggtgac gtcctgctgc gcggccatca ggtagccggt cagtgcggcc gccatgccct
294121 ggacgtcggt gagcgccttg gccagcagcg cgcgttcggt cttcagccgg ccgttgccag
294181 caccgctgtc gacgaactcc tggatctggc ctgacacgtg cgccaacgcc acgcccttgt
294241 cacggacgat tttgcggaag aagaagtctt gtgcctggat ggcggtggtg ccttcgtaca
294301 gggagtcgat cttggcgtcc cggatgtact gctcgatcgg atagtcctgc aagaagccgg
294361 atccacccag ggtttgcagg ctttcagtga gcttggcgta agcctgttcg gagcccacac
294421 ccttgactac cggcaacatc aggtcgttga ccttgacggc caacttggcg tccacaccgt
294481 gcaccacctc ggcgacagcc gcgtcctgga aagtggcggt gtagaggtag agcgcacgca
294541 ggccctcggc gtaagccttc tgggtcatca gcgagcggcg cacgtcgggg tgatgtgtga
294601 tcgtcacccg gggcgcggtc ttgtcggtca tctgggtcag gtcggcaccc tgcacgcggg
294661 acttggcgta ctgaagcgcg ttgaggtagc cggtggacag cgtcgcgatg gccttcgtgc
294721 cgaccatcat gcgggcctgc tcaatgacct cgaacatctg cgcgatgccg ttgtgtacct
294781 cgccgaccag ccagcccttg gcggggacgc cgtgttggcc gaacgccagt tcacaggtcg
294841 ccgagacctt taggcccatc ttgtgttcga cgttggtgac gaacacgcca ttgcgctcgc
294901 cgggttcgcc ggtttcgacg tcgaacagga acttgggcac gaagtacagc gacaggccct
294961 tggtgccggg accggcgccc tccgggcgag ccagcaccag gtggaagatg ttctcgaaca
295021 ggtcgccgga gtcacccgag gtaatgaacc gcttgacgcc gtcgatgtgc caggacccgt
295081 cggcctgttg gacagctttg gttcgggcag cgcccacatc ggagccggca tccggctcgg
295141 tgagcaccat ggtcgatccc cagccgcgtt cggcggctag gaccgcccac ttcttctgct
295201 cctcggtgcc gaggtggtag aggatctggg cgaagcccgc gccgccggcg tacatccata
295261 ccgccggatt ggcgcccaag atgtgctcat gcagcgccca gaccactgcc ttgggcatcg
295321 gcatgccccc gagtgcctcg tcgatgccga ccttgtccca accggcttcc agcatcgcgt
295381 tgactgactt tttgaacgat tccggcagca tcaccgagtg ggttttcggg tcgaaaacgg
295441 gcgggttgcg gtccccttcg acgaacgact cggccaccgg cccctcggcc agccggctga
295501 cctcggccag catgtcgcgg gcggtgtcga cgtcgacgtc gctgaattcg ccatggccca
295561 aagctttgtc gacgcccagc acttcgaaca ggttaaaaac ctggtcacgg acgttgctcc
295621 ggtagtggct cactgccgat cctcctcgtt gagagtgcca cctcagggtt gggtagggtt
295681 gggtactcga aaccaagtta cccaccagta acaccgtcaa aatatatccg ttgcataggt
295741 caatgcaagt tgatgtgagc tacattgcac caactaacta accaaccggt tgggttagcg
295801 gtgatcctgg ccgtgtcggt cctctcacct gcggcgatag cgatcaaatg aagaatatgc
295861 ggagtctagg gcggcagcgc ctggcagcgt agatcatcgg ctcacgcgga tgcggcctct
295921 tggtacggac atgcgcgcgg atgtccggcg agtagggtcg gatgcgaaaa ctacgtcctc
295981 ggctctaggg gcgaatgaag ttcggtgaac tcaacgaaca acctgacgcc gtcctcactg
296041 cgggaggcct tcggccattt cccgaccggg gtggtggcca tcgctgcgga ggtcgacgga
296101 gtgcggcaag gcttggcagc cagtaccttt gtcccggtct cgctggaacc gccgctggtg
296161 tcgttctgtg tgcagaacac ctcgacgaca tggccgaaac tcaccggcgt gccgatgctg
296221 ggcatcagcg tgctcggcga ggcccatgac gccgcagtgc gcacactggc cgcaaaaact
296281 ggggacaggt tcgccggttt ggagacggta tccaacgacg ccggcgccgt cttcatcaag
296341 ggcaccagcg tgtggctcga gagcgcgatc gagcagctgg tcccggcggg agatcacacc
296401 atcgtggtct tacgggtcaa ccaggtcaag gtggatccca acgtagcgcc cattgtgttc
296461 catcgcagcg tgctccgccg actcggcgtc taaacgtcta tacggacgcc cacttggtct
296521 gtccggacaa catagcggtc agcggcccat tctggttgcg ataaatgatg gtagatcacg
296581 tcattttgct tccagtagtc gtgcccatgt ttgagaggca caactattgg tcgctttcat
296641 tcgttgcgcg cagaccggtc tttgtatgac gatgatggga agttctatct gccgccaaaa
296701 gcagaatggc aggacgcagg atgaagcgat gagccgaccc gccggaaccg gtttccggga
296761 acgggtggga tgcatgccca cttgaggtct cgcggcaggc ggtggagcgt ggcaaaaacg
296821 tcgcatcggg tgagcagcgc cgatggcatg agtaagcgta ttttgcgttt gataatcgcg
296881 cagagcggct tctatagcgc cgcacttcag ctcgggaatg tctcgatcgt tctaccgttt
296941 gtggtagccg agctcgacgc cgaattgtgg atagcggctc ttatttttcc tgcattcacg
297001 gccggtgggg cgatcgggaa tgtggtcgcg ccgccggcgg tggccgccgt tccacgccgt
297061 caccgattgt tcattattgt gtcctgtttg gccgtcctgg ctggcgtcaa tgccttgtgc
297121 gcaaccatcg gcaaaggaag cgtcgctgga atcctattgg tggtcaatgt gacgctgatc
297181 ggggtcgttt cggcgatctc cttcgtcgcc ttcgcggatc tggtggcggc tatgccatca
297241 ggaaccgccc gagcccgcat tcttcttacc gaggtcggag taggggcggc tttgacggcc
297301 gtggtggcgg cgacgctgtc attcgtaccc gaccaacacc cattaagcag gaacattcac
297361 ctactgtgga cggcagccgt ggcaatggct atctcggcgg ccatatgccg ggcattgcct
297421 caccggatcg tccccagggt ccatgcggcg cccggtctgc acaaactcgt gtacgtcggt
297481 tggacggcta tccgaaccaa tggttggtat cgtcggtacc tgcttgtgca ggtactcttt
297541 ggctcggtcg tgctcgggtc ctcgttccac agcattcgcg tcgccgccgt acccggggac
297601 cagcccgacg aggtcgttgc cgtcgtcctt ttcgtctgcg tcggactctt gggtgggatc
297661 gcgttgtgga accgcgtccg ggagagattt ggcctggtcg gtttgtttgt cggcagtgca
297721 ctcgttagca tcgccgcggc agtgctatcc atcgcattcg atttggccgg agcgtggccc
297781 aacgtcgtcg ccatcggtct ggtgattgca ctggtatcca tcgccaatca aagcgtattc
297841 accgcaggcc aactgtggat tgcccgtgac gccgaacccg gcctgcgaac atccctcatc
297901 tccttcggcc agctcgtcat caacgcaggc ttagtcggta tgggtttggc gctggggttg
297961 attgcccagg atcacgatgc ggtgtggccg gtgatgatcg ttctgctgtt gaacctgacg
298021 gctgcctact cagcgacgcg gttcgctcca gccaagtccg tggatgttcg tggcttgcct
298081 caggtttcgc gcacttcccg acctaaaacc gggggttagc ggcgaaacag cttgctgccc
298141 agccatacca ccggatcata cttgcggtcg gcgacccgtt ctttcatcgg gatcagggca
298201 ttgtcggtga tcttgatgtt ttctgggcac acttcggtgc agcacttggt gatattgcag
298261 tagcccaggc cgtgctcttc ctgtgcttgg ctgcgtcggt cccgggtgtc cagcggatgc
298321 atttcgagtt cggcgattcg catcaggaag cgggggccgg cgaacgcatc cttgttttcc
298381 tcgtgatcgc gaactacgtg gcagacgttt tggcacagga agcattcaat gcacttgcgg
298441 aactcctgcg agcgtgcaac gtcgacttgc gccattcggt actcgctggg ctgtagctcc
298501 ttgggtggcg cgaaagacgg gatctcgcgc gctttttggt agttgaacga gacgtcggta
298561 acaagatcgc gaatcaccgg aaacgtccgc attggggtga ccgtgacgat ctcgtcctcg
298621 tcgaatgtcg acatccgcgt catgcacatc agtcgcggtt tgccgttgat ctcggccgag
298681 caggatccgc acttgccagc tttgcaattc cagcgcactg cgagatccgg tgtctgcgtc
298741 tgttgtagac ggaggatgac gtccagcacg acctcgccct cgttgacctc cacggtgaat
298801 tcgcggagtt cgccacagct ttcgtctccg cgccacaccc gcatactcgc gctgtacgtc
298861 atttagcctc tccgtcctgg atgctcggcc agctcttcgt cggtgtagta tttctccaac
298921 tccgagatct cgaagagctc cagcaagtcg ggtcgcatgg gcgtttgcag ctgctgggtg
298981 acgttgatgt ggcagttgga gtcgccggac ccgctgccac cggtgcccat ggtttcggtg
299041 gcccggcata ccagcaagat cctgcgccag ttggggtcca taccgggatg gtcgtctcgg
299101 gtgtggccgc ctcggctttc ggtgcgctgt agcgcagctc tggccacgca ctcgctgacc
299161 agcaacatgt tgcgcaggtc gatggacagg ttccagcccg gattgtattg acggtgacct
299221 tcgacgagta cgttgtggta gcgcgaccac agctcggcca aaagagtcag cgccctggat
299281 atttcgtcgg cgttgcggat gataccgacc agatcgttca tcacgtactg caagtccata
299341 tgcagcgcgt acggattctc cggcgccgag ccgtctttcg gtccttcgaa ggggctcagc
299401 gcctgctggg ccgccgcatc gatagcctcc gctgaaaccg ctggccggct gctcagtgcc
299461 cgtacgtaat ccgctgcgcc caggccggcc cgccggccga ataccagcag atcggacagc
299521 gaattgccgc ccagccggtt ggagccgtgc ataccgccgg cacactcacc ggcagcgaac
299581 aggcctggca ccgtggcggc gccggtgtcc gcgtctactt cgacaccgcc catcacgtag
299641 tgacacgtcg gcccgacttc cattgcctgc gttgtgatat cgacttcagc gagctctttg
299701 aactggtgat acatcgacgg caatcgccgt ttgatctcgg cgggtgtcag ccgggatgcg
299761 atgtcgaggt agacgccgcc gtgcggggta ccgcggccgg ccttgacctc tgagttgatc
299821 gcgcgcgcga cctcgtcgcg gggcagcaag tccggggtgc gtcgggccga gtcgttgtcc
299881 ttaagccact ggtcggcctc ttcctccgtc tcggcgtact ggcccttgaa caccggcgga
299941 atgtagtcga acatgaagcg agagttctcc gagtttttga gcactccgcc gtcgccgcga
300001 acaccctcag tgaccagaat tcccttgaca ctgggcggcc acaccatgcc cgtcgggtgg
300061 aactggacga actccatgtt gatcagcgtc gccccggccc gcagtgccaa cgcgtgcccg
300121 tctccggtgt actcccagga gttggatgtc accttgaacg acttgccgat cccgccagtg
300181 gcaagcacca ccgctggcgc ctcgaacacg atgaaccggc cgctttcccg ccagtagccg
300241 aaggctccgg cgatcgcgcc ttggtccttg agcagttcgg tgatggtgca ttcggcgaac
300301 actttgatcc gcgcttcgta gtcgccgagc tcggcgtggt cctcctgctg cagcgagaca
300361 accttttgct gcagggtgcg gatcaactcc aggccggtgc ggtcgccgac gtgcgccagt
300421 cgcggatagg tgtgtccgcc gaagttgcgc tgactgattc ggccatcgtc ggtgcggtcg
300481 aacagcgcgc cgtaggtctc caactcccag acccggtccg gcgcctcctt ggcgtgcagc
300541 tcggccatac gccagttgtt caggaacttt ccaccgcgca tcgtgtcgcc gaagtgagtc
300601 ttccaattgt ccttcgggtt ggcgttgccc atcgcggccg cgcagccgcc ttcggccatg
300661 accgtgtggg ccttgccgaa tagggatttg cacacgacgg ctactttcaa gccgcgttcc
300721 cgcgcctcga tgaccgcgcg taaccccgcg ccgccggcac cgatcacgac tacgtcgtag
300781 gagtgccgct cgacctcaac cataaaacct cgctcagctt ctgaaacgat ccttcagcca
300841 ataaatctga gatctgtgat gctgccactg gccaccagca tgatgtagaa atcggtgagc
300901 gccagggtcc ccagcgtgat ccacgcgaat tgcatgtgtc gggtattgag cttgctgacc
300961 tgtgtccaga tccagtatcg cactgggtgc ttggagaaat gcttgagccg accgccggtg
301021 gcgtgccggc acgaatggca cgagatggtg tatgcccaca gcagaaccac attgatcgtc
301081 aaaatgacat tgcccaaacc gaagccgaat ccggacggcg agtgaaatgc cgcgatcgcg
301141 tcataggtgt tgatcagcga caccaccacc gcgatataga agaaataccg gtgggtgttc
301201 tggacgatca gcggaagccg ggtttcaccg gtgtaatgag cccgcggctc gggcactgcg
301261 cagcttgtcg gcgactgcca taccgaccgg tagtaggcct tgcggtaata atagcaggtg
301321 agccggaatc caagcaggaa cggtaatacc atcgctccca acggaatcca ccctggaaaa
301381 tgcccgaacc agacgccgag atgactggcg ccgggctggc aggacgcgct gacgcacggc
301441 gagtagaacg gcgtcaggta atgatatttt tccacccagt attggctgcc ccagaacgcc
301501 cgagtggtcg catagcagat gaacgccaaa agaccgaggt tggtcagcag cggtggcaac
301561 caccagaggt cggtgcgaag cgtccgttct gggatttgtg cgcgggtggg tgtgaaaacg
301621 ccgatcgcag gacggttcgc cgtgggtgcg ctcatctaat gtgatcctct tcgcgtgtta
301681 tctcgtcgaa gggtacacag agaacggccc cctttttctg gggggctcgg ttgttcagta
301741 cctgtgacct ccgacaccct catcgtcgac atcgcgccaa aattcgcgat cgtactcggt
301801 gtcggggatg gcgattttct cgctgggttg cggtacggcg gcccgttcca ggtctaattc
301861 agagacgtcg gtgtcgagca attcgatgtc ggtgaggatc cggtcggcat cgatcacgat
301921 gcgacgcgtt gccgggttgt cgccgaatcg cgccttcagt gcggtcacgc accgccgcag
301981 tccgccgacg aggtcgtgca gttcggcgag ttcggcagtc gtggacaatg ggtgctccct
302041 gggctggcgg tgttacagat cacagtacgc tcccgatact agctatcgac ggacggagtc
302101 gttgggtcta ctcggcccaa tggcatgatc cggcggaccc atcggcccgg ccggatcatg
302161 ccgtatcgcg aactacttcg tgatggcgat gcgctgcgcc tgagtttcgg ctggggcctt
302221 gtaggcgccg gcaacccgga cggtcagcac accggcgtca taggaagccg cgatggcctc
302281 gctggtgacg tgcgcgggca gccggaacga gcggcggaat gatccgtagc ggatctcacg
302341 cagggtgcgg ccgtctttgt ctccggcgtc ttgcgtgtgc tcgtcgcggt gttcgccgcg
302401 gatcaccagg cggctcaccg gctggccagg gtcaagctcg acgttgacgt ccttgtcgac
302461 gtcaatgccg ggcagttcca aacggaccac cgcgtcgtcg ccatccttga cgatctcggc
302521 ggccggcgtg aagtctccgg cgaccgggcg gtaccagtcc gtcgtcgcgg cagggccgaa
302581 gaagtcacgt agccagcggt cccagggctc aacgtcccac accggacgcg accacaatgc
302641 gagattgttc atggttatct cctcatgctt cgttgtgagt tagctgtgtc cggcgcgttg
302701 ccggcccgct ataccaagaa cctgagtcga ccacgcttaa gttccacctc ggcgttcacc
302761 ggaagcgaac actgtcacac agccggtcgc caggtgtgat cacagcgtca tatgtgcgtc
302821 acattcggcg atttttcggt aatttgcccc tcataccctc agaccatgcc tacggctggg
302881 agttcgcgcg cgcctgccgc ggctcgcgag atcgtcgtgg tcggccacgg catggtgggc
302941 catcggctgg tcgaagcggt gcgtgcccgt gacgcggacg ggtcgctgcg gatcacggtg
303001 ctggccgagg agggcgatgc ggcctatgac cgggtcggcc tgacgtccta taccgaaagc
303061 tgggaccgcg ccctgttggc cttgccgggt aacgattacg ccggtgacca gcgggttcgg
303121 ttgctactaa acacccgagt cacccagatt gaccgggcaa ccaagtcggt ggtcaccgcg
303181 gcagggcaac ggcatcgcta cgacaccctg gtgctggcca ccggctccta cgcattcgtc
303241 ccgccggtgc ccggccacga cctgcccgcg tgccacgtct accgcacctt tgacgatctc
303301 gacgctatcc gcgccggcgc ccagcgcacc ctggacggcg gtcacaccga tggcggggtg
303361 gttatcggtg gcggcctgct gggcctggaa gccgccaatg cgctgcgcca gttcgggttg
303421 cagacacacg tcgtcgagat gatgccacga ttgatggccc aacagatcga cgaggccggg
303481 ggtgcactac tggccaggat gatcgccgat ctcgggatcg cggtgcacgt cgggaccggt
303541 accgagtcga tcgagtcggt gaagcattcg gatggctcgg tgtgggcgcg ggttcgcctg
303601 agcgacggcg aggtgatcga tgctggggtg gtgatctttg ccgccggcat ccggccgcgc
303661 gacgagttgg ccagggcggc ggggctggcg atcggcgacc ggggcggtgt gctcaccgac
303721 ttgtcctgcc ggacaagcga tcccgatatc tacgcggtcg gcgaagtcgc cgcgatagac
303781 gggcggtgtt acggcctggt cgggcccgga tacaccagcg ccgaggtggt ggccgaccga
303841 ctgctggacg ggtcggccga gttccccgaa gcggacctgt cgaccaaact caagctgttg
303901 ggtgtcgacg tcgccagctt cggcgacgcg atgggggcaa ccgagaactg cctcgaggtt
303961 gtcatcaatg acgcggtgaa gcgcacatat gccaagttgg tgctctccga cgacgccacc
304021 acgctgctcg gtggcgtgct ggtgggcgat gcctcgtcgt acggggtgct gcggccgatg
304081 gtcggcgccg aactgcccgg ggatcccctg gcgctgatcg cgccggccgg atctggggcc
304141 ggcgctggcg ctttaggtgt tggggcgctg ccggattcgg cccagatctg ctcgtgcaac
304201 aacgtcacca agggcgagct gaagtgcgcg attgccgacg gttgtgggga cgttcccgcg
304261 ctgaagtcat gcaccgcggc cggcacgtcg tgtgggtcgt gcgtgccgct gctcaagcag
304321 ctgctagaag ccgagggtgt ggagcagtcc aaggcgctgt gcgagcactt cagccagtcg
304381 cgcgcggagc tttttgaaat catcaccgcc accgaagtcc ggactttctc cgggttgctt
304441 gaccgctttg gacgcggaaa gggttgcgac atctgcaaac ccgtggtcgc ctctatcctg
304501 gcatccaccg gctccgacca cattttggac ggcgagcagg cctcgctaca agattccaac
304561 gaccacttcc tggccaacat ccagaagaac ggcagttact cggtggtgcc gagggtgcct
304621 ggcggtgaca tcaagccaga acacctgatt ttgatcggcc agatcgcaca ggacttcggc
304681 ctctacacca agatcaccgg cggtcagcgg atcgacttgt tcggcgcccg ggtggatcag
304741 ctgcccttga tctggcagcg actggttgat ggcggcatgg aatctgggca cgcctacggc
304801 aaggcggtgc ggaccgtgaa gagctgcgtg ggcagcgact ggtgccgcta cggtcagcag
304861 gattcggtgc agctggccat cgacctggaa ctgcgttatc gcgggctacg ggcaccgcac
304921 aaaataaagc tgggcgtctc gggttgcgcg cgggaatgcg ccgaggcgcg cggcaaggat
304981 gtgggcgtga tcgccaccga gaaaggctgg aacctttacg tcgccggcaa cggcggcatg
305041 acgcccaagc acgctcaact actggccagc gacctcgaca aagagacgct catccgctac
305101 atcgaccgct ttctcattta ctacatccgc acggccgacc ggctgcagcg aaccgcgcca
305161 tgggtggaat cgcttgggct ggaccatgtg cgcgaggtgg tctgcgagga ctcgctgggt
305221 ctggccgagg aattcgaggc cgcgatgcaa cgccatgtcg ccaactacaa gtgcgagtgg
305281 aagggcgtgc tggaggaccc ggacaagctg tcccggttcg tttccttcgt caacgccccc
305341 gatgccgtcg actcgacggt gaccttcacc gagcgtgccg ggcgcaaagt acctgtgtcc
305401 attggtatcc cgcgggtccg atcatgaagt ccgggaggac aaaggaggga ctgtgacgct
305461 tctcaacgac attcaggtat ggaccaccgc ctgcgcatac gaccatctca ttccgggacg
305521 tggtgtcggg gtgttactcg atgacggtag tcaggtggca ctgttccggc tcgacgacgg
305581 ctcggtgcac gcggtcggta acgtcgaccc gttctccggt gctgcggtga tgtcccgcgg
305641 catcgtcggt gatcgcggag gtcgcgccat ggtgcaatcg ccgatcctga agcaggcttt
305701 cgcgctcgac gatggctcgt gcctcgacga tccgcgcgtt tcggtgccgg tgtatccggc
305761 gcgcgtcaca cccgaaggcc gcattcaggt cgcgcgggta gcggtctagc tcaccccgcg
305821 aacctcacag cttgagcaca cgtccggcga tgaccagatg tacctcatcg cagacggctg
305881 ccacgcgtcg gttgattgtg cccagtagat cgcgaaacag cacgcccgaa gaatgggatg
305941 gcaccacccc gaggccgacc tcgttcgtca ccacgatcgc agtgggcaat ccggtcagcg
306001 cggcgcacaa cccgtcgagc cgtgcctcga ggacggcgta gacgtccgcg gtcgcagcag
306061 accacaacgc ctcgccatcc atgatggccg tcagccaggt gcccaagcag tccacgagca
306121 cgggacttcg tgcctcggac aaagccgtcg cgacgtcggc cgtttccacc gttagccagg
306181 tcggtgggcg gcgagcgcga tgcagtgcga cccgggcgtc ccaatcggga tcgctgccag
306241 cggccgggcg gccaggcgcg acgtagacga cgtcggccgc atcgcccaac aacgcttcgg
306301 cgtgcgtgga ctttcccgag cggacgccgc cagtgaccag tatccgcacc gggtcatcgt
306361 aggtggggcg gcctcatggc gcgcccggag cgagaaaggg caaggtcggc gggcaaccat
306421 ggcgggccag gttgagcagc gcatcgacgt cgaggtgtcg ttcgacgaga tcgccgagca
306481 ggtcgaggcg gcgctcgcgt gcggccagga agcatgagcc cgacggggcg aggccgagcg
306541 tctctcgcag gaaggcctcg cgcagggcgt cgccttccaa cgagccgtgc cacatggtgc
306601 cgaacaccgg tccgtcgcgc gcgccgccga ggaactcctc ggcggtgtca ccgcgggtga
306661 tccggccgtg gtgaatctcg taccccgacg cgggcacacc gagtccttcg ccgcgcggta
306721 gccgcagcac cttgtggggg gaaaatgcgg tctccacgtc gagcaaaccc aagccctcga
306781 cctcggtcac ctgccctccc ggaccttcga tgccgtacgg gtcgcgaatc acccggccca
306841 gcatctggaa cccgccacaa atgccgagca gcggcttgcc cgccgcaaca tgcaccagca
306901 gcgcacgatc taggtctcgc gccctcagcc aggctagatc ggcgatcgtt gcccgggtgc
306961 ccggcaacac gatcagatcg gcatcgtcca gcgcgcgggg gtcggaagcg aacacgacat
307021 ccaagtcggg ctcaagaccc aatgcgtcga catcggtgaa gttgctgatt cgtggcaggc
307081 gcacgacggc tacccggcgg gccccggtgc ccgccgcgcg ccggccctgt aggtcgaggg
307141 catcttcgga gtccagccag aggtcggggt gccacggcag ggtgccgtac accctgcgcc
307201 cggtgacccg ttccaggtcg cgcagacctg gcgccagcag gtcggagtcg ccccgaaact
307261 tattgaccac aaaccccgcg accagcgcct ggtcctcggc agccagcaac gcgacggtgc
307321 ccaggaacgc agcgaacacc ccgccgcggt cgatgtcacc gacgacgatg gtcggcagtc
307381 ccgcatgacg ggcaagcccc atgttgacgt agtcacctgc gcgcaggttg atttcggccg
307441 ggctgccggc gccctccgcg acaacgacgt cgtagcgggc ggcgagggcg tcgaaggcgc
307501 ggcatgcggc ctcggcgagc gctcgccgcc ccgcacacca gcttgacgac gccacctcgc
307561 cccagggctt gcccatcaac accacgtggc tgcggtgatc actggccggc ttgagcaaga
307621 ccgggttcat cgccgcctcg ggcgtggtcc tagccgcgag tgcctgcacc cattgcgccc
307681 gaccgatctc cacgcccgtg ccgtcggggc ctcggcagac catcgagttg ttggacatgt
307741 tctgcgcctt aaacggcgcc acccgcacac cgcgtcgggc caacgcgcgg cacagccccg
307801 cggtcacggc gctcttaccg gcgtcgcttg tcgtacccgc gaccagcaga cccgacatcc
307861 gtctcccgaa ggtttctcac tccacccggg tcgctgagtc ggtgtcccag gttccgggca
307921 tcattggcgt gcgtgggctg ccgccgaacg cgtcgttggg taacgtgatc agtcctgcga
307981 cttgtccggg actggccttg tgggttgttc cggcgaaacc cagggttccc gctccttgag
308041 gcgaacccgt cgggtcgtgg ccggtttcgg ggtctaaatc caggtattcg taaccgcggc
308101 cgagctgttt gatctttggc cgccgacgcc gctgcggttg aacctgttcc tcgggcgccg
308161 ccgcggccgc tggggcctcg gcgctgtcgg gttccggcgt cttctttcga acgccggtgc
308221 cgacggcctt cctggcctgc gccgccgagt tcaggtcacc caccaggtac ccgaagcttt
308281 gtatgccggc tccggtcacc ggcggcgggg cggtcaccgg cggcggtggc ggcccgggcg
308341 ggggcgtcgg cgcggtcacg gccgtggggg ccggggctgg ggctggagtt ggggtggggg
308401 tcgggatact cggggcaatc gccgcgaccg gcgggatgac gggcggcgcg gatggcggga
308461 tgccaaccag gcccgccagc ccagacaagc ccgcgaagcc gcctgctgca ctcgcagggg
308521 caagggtcaa cggcgccagc ggggcggcta gcaggggcag cgccgccggg agcaacgcaa
308581 gagtttgctc gagcagcgtt ttaaccagcg cgatggtatc ggtgatgatc gtgccaatgg
308641 cttcgaccgt ggtgaacatc agggtaaaag cgatagttgc gggattgccc gacgcgaacg
308701 ccgccgccag atccgccccg atgaatgcga aggtttgcga caggaaggcg acataagatc
308761 cgatgtccat ggggtagcca agggcgaacg caatgttggc cgggcttagg aaggttagcg
308821 gattacccag cgagggcagc cacggatcaa atccggaaaa catcgcttgc aaaaagggga
308881 ggttggtcag ccagttgatg aacggttgta taacgttgtt gtagaagtcg gtatacccga
308941 tcttctgcaa ccattgcagc cattcctgga cttggttcgg ctcgtcggaa gccgctgtcg
309001 gcgcgttggc tttcacgatc tggggggctg gggtggtctg cggtgcggcg gccaccgccg
309061 cggtcgagac cgcttgatag ctggccatcg tggtggcggc ctggatccac atccgcgcgt
309121 agtcggactc gttgagcgcg atcgggatgg tgttgatgcc gaagaagttc gtcgccatca
309181 gcacgccgtg gagggcgtgg ttggcgccca gctcggccaa cgttggcatc gcggccaagg
309241 cggtgccgta ggcggtggcc gcggtttctt gccgggtggc catggccgcg ctgttagcgc
309301 tggcctgcac cagccacgcc agataagggg tatgggcggc cacgtaaacc gcggcggtcg
309361 ggccgtccca ggtgccggcc tgtacggcgg ccaacagcgc ggccagctcg tcggccgtct
309421 ccgcgtaggc gatgctcaac gagtgccacc cctcggccga caccagcagc ggaccgggcc
309481 caggcccgct gcttagcagc gccgagtgca cctctggggg cgaagccatc cagatcgggg
309541 cggtcatcgg cggctgaccg ccggcggagg tgtcgtcgcg tcgcgagcag ccacgttaag
309601 gcccagcagc gtggtggtgg cccgaccgct agacaaggtt tggagcgtca tgaccggtta
309661 gctttctcgg ggtacaccgc cccgggtggc aggacgcgat gacgcgagtc tcctggctcc
309721 cggatcgttg cttgcctcgc cttccagcct gtggccgtgg cttacgaggg tcgctccccg
309781 gtgacagtgg cgggaccgcg ccggattctc accggcttcc tgcatcgtca tcgcctgacg
309841 ggaagaatat tggcatgcag agcgtggatt tgcacgttga gcggcatttg ccaagcaggg
309901 gtcggtcaca tcgcacggtc gcaacagtca catgtgtcac tgcactaggc gacatccgat
309961 ctgcccagct ctcagcgaca ggcgcctggc cggcggtttt gttcccaagt tggtcgtggc
310021 tgtgcgggat tggaggcggc gttgacctgc agaaaccgag ttgtcgcgct tagctgggca
310081 cagcgaccat cgccgacggc ggagctcggc gtcggtgagt cgcttcggtc ggccggggcg
310141 gcgcgattcg ggttcgacca cgtggtcgtc gaccagctga cgcgccgaac gtgcaaccac
310201 ggcggcagcg cccggcgacg tgtccccgcc accagtacac gttcggcgca gccagtgcac
310261 acacggcacg gagtttagga cttactcatt tggctatccg cgaccgatat cgccgaccag
310321 gtagcgctgc attgtcgggc caatggcgtc gaccagcatc tccaccgaca tggagtgcag
310381 cggctcagaa cgcaccccgt agcgcatgat gcccaaaccg acgagttgag cggcgcacag
310441 cgacgctcgg atggcaatct tgtcggcccc gagcatcttg agcaacgggt tgaagaccgg
310501 tccgatgaac atggactgca cgatctcggc ggtcttggct agcccggtgg ttgcgatggc
310561 gctcgccgca aagggaccgc cgccggccgc atcccaggtg gtgatcagca cgtagagggt
310621 tcggcggcct acctggttga cgcttccggt gacgattttt tcgatgaaat ccggtgtgcc
310681 gaagggcaac cgcagcatct tcgctaccgg gtcgaggagt ccgcgtgatg gctcttggct
310741 acgggccatg gtgtcaggat caccccgctg tgatcaaaga tcaagcgtca ccggtgtcgg
310801 cgtgccatgc cagcggtgca gccgttgctg acgtgctacc gcgctgcgaa atcggttcgc
310861 gaccagctgt gccaagcccg gatgggtgcc gagcggtcgg gttaccacat cggcaccgga
310921 tgcccgcagc cgctcttgaa aaaggccttc tgccaacagg aaggaggcga ccgcgacgcg
310981 gcgcgcacct cggttggctt cggcccggtc tcgggcccgc tgcacagccg tgcgcacatc
311041 cggaccgccg gtgcccgcaa atcccatgtc cacccatgat ccggtcagtt cggacactag
311101 cgtccgagtg gtgtgcaggt cggcacgtgc ccgcctatcc gacgcgccgg ccgctgcgag
311161 gatcactgaa tcgccaggac gccaaccgga ttccaccagc tgctgggtga ctatctgcgc
311221 gatctcacgg catggcccca acgcgggggt gaccgtgaca tgcgggtgcg cactggctgc
311281 gacatgagcg ggcaggtcgg tgcgaacatg atatccgcgg gacaagaacg cgggcaccac
311341 gattgcggga cggcaggaaa gggcggaaag cacttcgctg ggtgagggtc cgagcacatc
311401 aacgaaggcg acctgcacag tgcggtcgac gagcgcgctc acttgcgcgg cgatgtccgc
311461 tatcatcgcg acaccggacg gtctgcgggt tccgtgggcc gtcaagatca ggttcatacg
311521 tcatcgtgcc ggctgtcaac ggcgagacgg tagccacgtt tcaccactgt tgccacgatg
311581 ttcttgtcgc ccagagccgt tcgtagccgc aggacggcgg tgtccacggc gtgggtgtcg
311641 ctgccgtcgc cgggtaggac gcgtagcaag tcgccacgag agacgacgcc gccggggcga
311701 tgtaccaacg cgcgcaaaat cgccattccg gacggcgata gtggcttcac cgaatcatcc
311761 accagcacag aggttccacg gatctcgatc acgtggccgg ctgctttgaa cgtgcacgaa
311821 cccagcagcg gcagctcctc ggcaatgtgg cgggctaagg ctcccaaccg cattcgctcg
311881 ggagccgacg tcgggacgcc ctttcggatc aacggccgcg aagttaccgg gccgacacac
311941 atcgcgtgca cgtcggtacg cagcgcagcc aacagttggt cctcgatatc caattcacgg
312001 ctgcgttcta gcaccgcggc tgcggcaggt gccgacgtga aggtgaccgc gtcgaattgt
312061 cgtcgcgcga tcccggtgac taaatggtcg aacacgccgc ctagtggcgc cggcttccac
312121 cggtaaaccc ggatcggcac cacttgcgcg ccggcgaaac gtaacccgcc cagaaattcc
312181 ggaaacgggt cccagctgtc ggcggcaccg tgcagctgga cggcaatacg cgtacgggac
312241 acccccgatt cgagcagata ttccagcact tcatgcgacg attcagagtc gggggaccac
312301 tcttcacgca ggccggcggc acgcagcgca ccagttgcct ttggtccgcg ggagatgatc
312361 cgggccgacg acaacgattc caggagctcg ttggccagcc cccacccctc ggccgcggcc
312421 aaccagccgc gaaatccgat gccggtgtgg gcgaccagaa tgtcaggcgg gtcggcgatc
312481 aacgcctcgg tgttgttctg cagttcatcg tcgtcgggaa gcgcgatcat cttgatcgct
312541 ggggcactac agacctcggc gccctggcgg cgaagcaatg cgcacagctc ttcggcgcgg
312601 cgagcggatg tcaccgcgat ccggtagccg gtcagtggcg ccgagtgtgc ctgggccata
312661 tgacgtgtct aggcctgtga ggtttcagtc gcgttaccag gcaattgctg ccggattgcc
312721 cattgccgat acccacctct gtggcttcgg gcgtggcgct agacgtaggc caagcccgcg
312781 ggtgcggtgg tcgccggcac gagctcgccg gcgctcttta ggccccgacg cacataaatc
312841 gcccaggtca gcaccgaggc gaccaggtag aacaccccga aggcccaaaa tgccgaggtg
312901 gccgtgccac tggtcaggta ggactctcgc agagccaggt tgacgcccac tccgccgagc
312961 gcgccgaccg ccccggccag gccgatcagc gcgcctgaca tcgaccgcga ccactgcctg
313021 cgctcggctt cactgatctg cagcgaatgg ctgcgcgcct cgaagatcga cggaatcatc
313081 ttgtacacag agccattgcc gatgccggac aaaatgaaca gagccgtgaa gccgatgacg
313141 tagccgacca tcgtcgcagt cggcatcggc ccggccaggt ggtcaccgaa agtgcttgcg
313201 ctgatgagta ttccggtggc cagcagcatg gcgcagaagg cagctagggt gactcggccg
313261 ccaccgatac ggtcggcgag cttgccgcca tatattcggg acagcgatcc caatagcggc
313321 cccaggaagg cgatctgggc cgcatgcagc gaggcctgcg ccgtgctctg accgctggcg
313381 atgaagttga tctgcagcac ctgaccgaat gcgaaagaga acccgatgaa cgagccgaaa
313441 gtgccgatgt acagcagcga gatcacccag gtgtgcggct cggacactac cgcacgcatg
313501 gtgttcagct cgatgcgata ctccgtcagg ttgtccatgt acagtgcggc gccgaggccg
313561 gcgaccgcca gcagcaccag atatatcgcg cacacccagt agggctcgcg gtcaccggcc
313621 gttgcgatca ccagcaggcc gaccaactgc accatcggca ccccgaggtt gccgccaccc
313681 gcgttgagcg caagcgcggc gcccttgagt cgttgcggaa agaaagcgtt gatgttcgtc
313741 atggaggcgg cgaagttgcc gccgccgagg ccggctagcg caccgcacac cagatacggc
313801 cacagtggca aaccagggtt ggccagcaac agaatgctgc caacggtcgg aatcaacagc
313861 accagtgcgg aaaagatggt ccagttgcgc cccccgaact ttgcggtggc aaatgtgtaa
313921 gggaagcgca ggcatgcccc gaccaaggtc gcggtggcgc cgagcaggaa cttgtcgccg
313981 gcggaaaagc cgtacaccga tgtgggcatg aacagcacca tcaccgacca gagggaccag
314041 acggaaaatc cgacgtgctc ggcggccacc gaccagatca gattgcgtcg ggcgatgaat
314101 ttgttgccgg cctcccacgc caccgagtct tcgggatccc agtcggagat ctggtgggaa
314161 cggcccatac tgacccctat cgtgatcgac gttctcgatc acgctagaaa tcctttgttg
314221 cccgggcgct tccggtagtg accccggcgt gaactttcgc tcacacggtt accgccagcg
314281 tgtgagggcg gccgtgcagc ggagcggatt accagacgtc gcccgcgcgc caatcgcaca
314341 tcagctccgc cgaggtgtcc aggctgatgt cgatgggcag gacgaacacc gttccgtcgt
314401 catcgggtgt acggactgga ccggttggtg ccagtaccga tgtcgggccg tgccagggca
314461 gccagccgcg tgaggcgtac agtctgcggg cccgcgccga ggaactgagc gctccgagct
314521 ggtaagcgcc gcgcatcacc tgctcgacgg cgtccaacag cgcgctcacc aggcgttggc
314581 cccgccagtc cgcccgcacc gcaacgcctt cgacgtaccc gcagcgcagc gcgttgccgc
314641 ggtagatcag tcgccgctgg atcaccgcgg catgcgcgat gatcgccccg tgatgccaga
314701 tcagggcgtg catcccaccc agcgtgtgct cccagtcggt ctcggtgaag tcaccggcaa
314761 acgcgccggt gaccatctga cggatgtcct ggcgggtctc gctgtcaaga tcggcggtgt
314821 ggaccaggcg ggccgtgtgt acctgggtgt gcacagtccc tgtctaccag gcttgtgtta
314881 caccctggcc aggcaaccga gaccggggtc gtgcccagtg cagtcgcaca tattggccgg
314941 gccgtatctg cgcgaccttg tcgatgtcct cgtcggtgat gacgccgacg accggatagc
315001 ttccggtgat cgggtgatcc ggccccagga tcaccggtaa tccgttgggc ggcacctgga
315061 ttgcgccgcg ggtaacgcct tcgccgggca gttgccgatc cggccagcgg tgctgtagcg
315121 ggcggccctg tagccgcatt cctacgcggt cactgcggtt ggacgccatc cagatggtat
315181 gcaccaacgc gtccgggtcc accagccagt cgtcgcgcgg cccgggcacc acccgcagct
315241 ccaccagatg ctcctcgata gcggccaccg gtgcctggtc gagttcggga tagtcgtcgg
315301 tgtgttcgcc gaccggcagc acgtctccgg cccgtagcgg cgacgggccg atcgccgaca
315361 tcacgtcgta gctgcgtgac cccagcacgg gctccacaca gacgccgccg cgcaccgcca
315421 gataggtccg cagcccggcc cgtggggtgc ccagtgagat cacctggccg tcccggacgt
315481 ggtgaatgct gttggtgccg accatgattc cgttcacggt cggatcggtg tcggcgcccg
315541 tcaccgcgat gtcgacgtcg ccgccgcgaa cccgcgccga gaagccgccg aaggtcactt
315601 cgaccgtggc ccaatcgtcg gggttggcga ctagccggtt ggccagcgtg tgggagcggc
315661 ggtcggcggc accggatcga ccgacaccga gatgggccag tccggcacgg ccgaggtctt
315721 cgacgagggc cagcggtccg ctgcgcagga tttccagtgt tgtcatggct gcttcctcca
315781 gctcaggcgg cccggaactg aacccacatg cccggtgtga gcagcgccgg ctggggtcgg
315841 tcgacatccc acaggaccgc gtcggtgtgg ccgatgatct gccaatcgct gggcgcttga
315901 gatggatata tcgcgctgaa tccgtcggcg agggcgaccg atccgggcgg catcgaggtg
315961 cgccgttcgg gccggcgcgg cacccgcagg ctcgggtcgc cgtcgatcag gtaggcgaac
316021 cccggggcgg acccactgaa tcccgcccgc catccggtgg cggtgtgggc gttgatgacc
316081 gctgcggtgg tcaggccggt gcagcgggcg acctcggcga ggtctgggcc gtcgtagacg
316141 acgtcgatta ccaggtcgca tcggtgatcg gccgcagcca ccgcctcggg ggtgacccgc
316201 aacctgcgca gccgctgacg ggtgacccct tggtagcggg gcgcgtccag cttcaccaat
316261 acggtgcgcg aggccgcaac gatgtcgacc acaccgggta gcgccgcggc tcgcaatgca
316321 tcggtccatg ccattgcgtc agcggtgctg tcacattgca gcatcagcgc atggtcgccg
316381 tagtcgagca cggtgcaggc caatgccgcg tccataaaga cgtccatcac actcatgcgt
316441 cgacggtagc gctgcaatct tcggctcggc cagggatttt cgagactgcc agaggtgcct
316501 tagcaaatgc tcatgcgccc aagatctggc tgatctgtgg cggcagttgc tcggccacca
316561 cgggataact cagcaccgac gagaaggcga tggctccggc ctgttccttg gaagtgaaga
316621 tgtggcgccg ctgggcggtt gcctgcgacg ccgcaatctc cgggtcggcc aacaacgcct
316681 tctcgtcctc ggggctctcg gtcatccaga tcagcacatc ggcggcatca agcaccgctt
316741 taatgtgatc gcgcggaatg acgccgcgct gatcgacggc gaagggtttg atgctgtcgg
316801 cgatcaccag acccatgtcg ttgaggaagt cagttcgcca gcccgccagg gttgcgacca
316861 cgttgccctg ccagaggcga ccctgcagca acagcgcctt cttgccccgc cagcgcggat
316921 gccgctgcgc caccgcggcg aacttctggt cgacggcctc gatcagcgac ctcatccggt
316981 cggccgcaaa caccgcctgg ccgatcgacc tggcctggtc cttccacggc tcgaagaatg
317041 cgtcgccgcc ggactgggcg acggtcgggg cgatcgccga cagctgctga taggtatcgg
317101 cgtccacccc ggcgttgatc gccacgatca ggtcgggttt taaggcggcg attcggtcga
317161 tctgaatccc gttgtccagg ttcaataccg ccggccgcgc cccgccgagc ttgggcgccg
317221 cccacggcca caccgcaaac ggctggtcac cgaaccagtc ggtcaccgcg atgggcacca
317281 catcgaccgc gagcaagtcg tcctgctcgg tgtagccggc gctgaccacg cgcttgggtg
317341 gctctttgat gacggtctga ccgaacaggt gggtgatagt taccgccgcg ccgccaggag
317401 tgcccggcgg gggtttgggc gatgaacagc ccgcgaacag cccggtggct gctgcagcct
317461 cggcgacctg caagaatccc cggcggctgc atccctgtcg cacagcgtga gggtatcgcg
317521 cgcgttaccg ccggcgtcgg gcgctggtac ttgctggccc gtatccgccg ccgccggggg
317581 tttcgatcac cagcgtgtcg cccggctcga cgtgcgttga gccgcatccg gccaactcga
317641 cggtgctgcc gtcggcgcgt tccactcggt tgcgtcccag ctctccgggg gagccgccgg
317701 ccatgccgta gggccgaacc cgccgatgac cggagagcgt gctgaccgtc atcggctcgg
317761 tgaactcgag gcgtcggacg gcgccgtcgc cgccccgcca gcgaccggcg cccccgctgc
317821 cctgacgtac ggcgaactcg cgcagcaaca ccgggtagcg ccactccagc acctcgggat
317881 cggtgagccg ggagttggtc atgtgcgtct gcaccaccga ggccccgtgg tacccgtcac
317941 cggccccgga gcccgatcct acggtttcgt agtactggtg ccgctcgttg ccgaacgtga
318001 cgttgttcat cgtcccggat ccctcggcct gcacacccaa cgcggcgaac agcgcgccgg
318061 tgatcgcctg cgaggtttcg acgttgccag cgaccaccgc ggcgggatgg gttggtgcga
318121 gcatcgagcc ttcggggacg acgatacgca acgggcgcag gcaaccgtcg ttgagcggga
318181 tgtcgtcggc gaccagggtc cggaacacgt agagcaccgc cgcattcacc accgaggtcg
318241 gtgcgttgaa gttggtgtcc agctgagccg aggttccggt gaagtcgatg gtcgcgctgc
318301 gggcggcgcg gtcgacggtg atgcgcacgg cgatcgtcgc gcccgaatcc atgcggtagc
318361 ggtaggcgcc gttgtcgagc cggtcgatga cccggcggac cgcttcctcg gcgttgtcct
318421 ggacgtggcg catgtaggcc gccaccacgt cgcggccgaa gtggtcgatc atttttccga
318481 cctcgtcgac gcccttttgg ttggcggcga tctgcgcgcg cagatcggcg aggttggtgt
318541 cgggattgcg ggaaccgaac ggcgcctcgg taagcaggcg ccgggtttcg gcctcgcgga
318601 accgtccgtt ctcggcgagc agccagttgt cgaacagcac gccctcttcg tggatctcgc
318661 ggctgtcggc gggcatggag ccgggggtga tgccgccgat ttcggcgtgg tgcccgcgag
318721 aggcgacaaa gaataggacg tcctcgccgc cggtgttgaa caccggggtg atcactgtga
318781 tgtccggcag gtgggtgccg ccgtggtacg ggtcgttgac ggcgtatacg tcaccgggct
318841 tcatgccgct caagcgccgg cggatcactt ccttgacggt ggtgcccatc gagccgaggt
318901 gcaccggaat gtgcggggcg ttggcgacca ggttgccgtc cggatcgaac agcgcgcagg
318961 agaagtccag ccgctcccgg atgttcaccg actgggcggt ggcttccagc cggaagccca
319021 tctgctcggc gatcgacatg aacaggttgt tgaagatctc caacagcacc gggtcggcct
319081 cgaaaccggc ctcgaaaccg gcccgagtgg ccgcatcggg ccgcggcggg gtgaccactc
319141 gttgcgcgag caggtgcccg gtctccgtca tcgtcgcctg ccagccgtcg tcgacgacgg
319201 tggtggcgtt ggcctcggcg atgatcgccg gaccggtcag cacgtcgccc ggccgcatcg
319261 cctccctacg ccgcagcggt gcgtcgcgcc acaatccgtt cgaatagatc cgcacggttt
319321 ccgacgagcc ggtggtgtcg ttggcctgat cgcccagctg ggacaggtcg ggctggtcgg
319381 tgagcccggt cgcctcgacc gagatcgctt cggcgatcag cggacgatcc agcaggaacg
319441 tgtacagcgc gcggtggctg ctttcaaacg ccgtggccat ggtctcgatc tcggccagtt
319501 gcacggggat cgcggtatcg gttccctcat agcgcaggtg cacccggcga accacccgga
319561 tgcgctcacc cgggacgccc tcgtccagca actcggcgcg ggcggctcgt tcgagggatt
319621 ccgcaacgct ggccaaacgc tgtggcgcgg cgggtccgag cgggatctcc accgattgtt
319681 cgcgcattgc ggtggtgtcg gccaggccga tccccagcgc ggaaagcacg ccggccattg
319741 gtgggatcag caccgtgcgg atgccgaggg cgtcggccac cgcacatgcg tgctgaccgc
319801 cggcgccgcc gaacgtcgtc agcgcgtacc gcgtcacgtc gtgtcccttt tgcacggaga
319861 tctttttgac cgcgttggcc atgttcgcca ccgcgatccg cagatatccc tcggcgacct
319921 gctcgggtga ccggtcgtcg ccggtccgcg cggcgatgtc ggcggccagg tcggtgaagc
319981 cacgccgcac ggtcccggcg tccagcggct ggtcgccgga aggaccgaat acggacggga
320041 agtgggtggg ctggatgcgg ccgagcatca cgttggcgtc ggtgacgcac agcggtccgc
320101 cgccgcggta gcaggccggg ccggggtcgg ctccggccga gtccgggccg actcggtagc
320161 ggctcccgtc gaaatgcaga atcgacccgc cgccggcggc caccgtgtgg atgtccagca
320221 tcggcgcgcg cagccggacc ccggcaacct gggtcgtgaa gacgcgttcg tactcgccgg
320281 cgtagtgcga cacgtcggtc gaggtgccgc ccatgtcgaa gccaataaca tgatcgaagc
320341 cggccagcgc cgacatccgc accatgccga cgatgccgcc ggccggacca gacagaatcg
320401 cgtccttgcc gcggaagtgc ccggcctgcg ccagcccccc gttggactgc atgaacatca
320461 gtcgcacacc ccgcatctgg tcggccacct ggttgatgta tcggcgcagc accggggaca
320521 agtaggcgtc gaccacggtg gtatccccgc gcgggaccag tttcatcagc gggctgacct
320581 cagatgacaa cgagatctgg gcgaagccga tgcgctgcgc cagcgtaccg atttctcgct
320641 cgtgtcccgg gtagaggtaa ctgtgcaggc acaccaccgc gaccgcgcgg attccgtccg
320701 catgggcctg ccgcatcttc tcgcccaatg cctccaggtc gggtgcccgc agcacccggc
320761 cgtcggctgt gacccgttca tcgacctcga cgacccgctc ataaagcatc tcgggcaaca
320821 cgatccgccg gtcgaagatg cgcggacgat tctggtaggc gatgcgcagg gcgtcgccga
320881 aaccgcgggt gatcaccagc agtgtgcgct cacccgtgcg ctcgagcaac gcattggtcg
320941 ccaccgtggt gcccatccgc accgcgtcga cgcgcgtgcc cgcctcgccg ttcgctagca
321001 gcgcacggat gccggccacc gcggcgtcgc gatagcgtgc cgggttgtcc gacagcagct
321061 tgtgggtcag cagccgtccg tccggccggc gcgccacaac gtcggtgaac gtgccacccc
321121 ggtcgaccca gaagtgccac cccgcgccaa ccacccggac tcccccttca cgctcgcagc
321181 cggtcccgtc ctcacaacgg cagacgggcc gaagccacct aaaggtatct ccgctgtaac
321241 agcgcgcatc cgggccggta acagggtctc tttagcgtcg agccgtcatt accgctgatg
321301 tcgcccgctt gtcgacagga gacctaaccg atggcactca ccaccgcccc ggcaatcgat
321361 tatgcgctgc cacgccagca ggatgagggc gatcactgga tcgacgactg gcgcccggaa
321421 gacccggtgt tctgggagac gatcggcagg ccgatcgccc gccgtaacct gatcttctcc
321481 atcttcgccg agcacgtcgg cttcagcgtg tggatgctgt ggagcatcgt ggttgtccag
321541 atgaccgccg ccgctcccgg gcaccccgcc gcgtccggct gggcgctgtc cgccagccag
321601 gccctatgtt tggtcgccgt ccccagcggt gtcggggcgt tcctccggct gccgtacacc
321661 ttcgcgatcc cgatctttgg tggccgcaac tggacgaccg tctcggcggc gctgctggtg
321721 atcccgtgcc tgctgctggc ttgggcggtg agccaccctt ccctgccgtt cgcggtgttg
321781 gtggtgatcg cggccaccgc cggtttcggt ggcggcaact ttgcctcatc gatggccaac
321841 atctcgttct tctacccgga gaaggacaag ggttgggcgc tgggcctgaa cgcggccgga
321901 ggcaacatcg gggtggcggt ggtgcagaag atcattccgc ccatcgtggt cgccggcagt
321961 ggggtggcac tgtcgcgtgc cggactgttc ttcgtgccct tggccgtcgc cgccgcggtg
322021 tgcgcattcc tgtttatgaa caacctcacg gaggccaagg ccgatgtgaa gccggtgtgg
322081 cagtcgctgc ggcatgccga cacctggatc atgtcgctgc tgtacatcgg cacctttggg
322141 tcgttcatcg ggtattcggc ggccttcccg acgttgctca agaccgtgtt tggccgtggt
322201 gacatcgcgt tgggttgggc cttcctcggc gcgggcatcg gttccctggt ccgtccgctg
322261 ggcggcaagc tcgccgaccg gatcggcggt gcgcggatca ccgcggccag tttcgtcatg
322321 ctggcggccg gggcggctgc ggcgttgtgg tcggtgcagt cggtcaatct gccggtgttc
322381 ttcgtcagct tcatgttctt gttcgttgcc accggcatcg gcaatggttc gagctaccgg
322441 atgatctcga ggatcttcca ggtcaaaggc gaagtcgccg gcggggatcc ggaaacgatg
322501 gtgaacatgc gccgacaggc cgccggagcg ctgggcatca tctcctcgat cggcgcgttc
322561 ggcgggtttg tggtgccgct ggcctacgcc tggtcgaagg tgcacttcgg caatatcgaa
322621 cccgccctgc acttctacgt ggcgttcttc cttgccctgc tcgtcgtcac ctggtactgc
322681 tacctgcgta gaaccacccc catgggccag gtgggggtgt agttagcccg gcggcggtct
322741 cacgttgtga gccacgcgca aactcagact ctgccgatgt caacgcccag ctcggcaccg
322801 agcttgtcca gcggcatggt gacgtgctct cgctcgtgca cgctgagccg gtcgcgcagg
322861 tcttcaagct cttccattag gctctcgtag cgctcagctg agatgaggat ggctgcgggt
322921 cggccatgat tcatcaacac gacgtcatcg tcggcggatt cacgcacaag cctcgatagg
322981 tgagcgcggg cttcactaat aggcactaga ctgctggtca tcggtagacc ccccttcggt
323041 gtccgacgcg agtaacggtg atgacacgcg ctgcgtcgtc gacgatgtaa acaacgcgat
323101 agttgccgag gcggatgcgg taagtggtgt cgaagccact catcttctcg cagccacgcg
323161 ggcgcggttc gtcggcgagc gcggcgacgg cggtcagatg cgccgctggt cgtggcggtg
323221 cagccgttgg attgctttag ctgccgagtt ctcgatttcg accgcgtacc cacttgccat
323281 acaaaaatgt acagacttca gatgcataat ataagcgcta attttgccga cgcgctctca
323341 ccgcggccac gggctgtagt cggcgatcag ctcctcctgc ggcgggcgct ggtcggccgg
323401 gacgtgctgc aggttgatcc ggatccgata ccagatcgaa ctcggcccgc gcatgccgtc
323461 gaccagcaca tcggcgggcc gcagcaaagc cgcggcgccg ggataccggt cgcgccagat
323521 gtccaacgcc gccatcgcct cggcccgcgt cttggcgcgg gcgatctcga tcagcggctt
323581 ggcggattgc gccttctgcg gcggacccag ttcctcggcc agcatcaaca gccggtcgag
323641 ccggccaacc gcgtcatcca tcccggccca ggggtcaccg atgtcggcca accggctggg
323701 cacggtggcc atggtgaaca ccgccgggtc gcagccgggc acctcctccc agtgcagcgg
323761 cgtggacacc cgggcatccg gggtggcccg caccgagtag gccgacgcga ccgtgcggtc
323821 cttggcgttc tggttgaagt cgacgaacac gccctcgcgt tcttccttcc accaacgact
323881 ggttgccgcg tcgggtaggc gccgttcgac ctcacgcgca acggtctggg cggccaggcg
323941 cacctgggga aacgaccagc aaggcgcgat ccgggcatag acgtgaaagc cccgcgaccc
324001 ggacgtcttc ggccatgcgg tcaacccgta atcctccagc acctcccgga ccaccaacgc
324061 gacctcgacg acccgctgcc acgcgacccc gggcatcggg tccaagtcca cccgcagctc
324121 gtcgggatga tcgaggtcgc cggcgagcac cggatgcgga ttgagatcca cacaccccag
324181 gttgatcacc cacgccagcc cggcggcgtc gtgaatgacc gcctccgcgg cggagcggcc
324241 cgacgcatag tgcagctcgg ccacgtccac ccagtctggc cggtttgccg gtgcgcgctt
324301 ctgaaacacc gcctcggcgg agatgccctt gacgaaacgc ttgagaatca tcggccggcc
324361 ggccaccccg cgcatcgccc cctcggccac ggcgaggtaa tagcggacca gatcgaactt
324421 ggtgtagccc tttcgatcgt tgtgagcggg gaagacgacc ctgcccggat gcgtgacgat
324481 gacctggcgt ccgtgcacgt ccagcgacac cggggcggcc atgcggctca tggtaatttg
324541 cgacccgcct cacatagggt gaggtcatgc ctaacctcac tgatctgccc gggcaggccg
324601 tctccaagct ccagaagtcc atcggacagt acgtcgcgcg cggcactgcc gagttgcatt
324661 acctgcggaa gatcatcgaa tcgggcgcga tcgggctgga gccgccgctg aactacgccg
324721 cgctcgcagc cgatatccgc aagtgggggg aagtcggcat gctgccgtcg cacaatgcca
324781 ggcgcgcccc caaccgggcg gccgtcatcg acgaagaagg cacgctcacg ttttccgaac
324841 tcgacgaggc cgcacacgcg gtggccaatg gcctactggc caagggtgtc cgcgccgggg
324901 acggcgtcgc catcttggcg cgcaaccacc gctggtttgt catcgccaac tacggggcgg
324961 cccgagtggg ggcccgcatc atcttgctca acagcgagtt ctccggcccg cagatcaaag
325021 aggtgtcgga ccgtgagggc gccaaggtga tcatctacga cgacgagtac accaaggccg
325081 tcagcttggc ccagccaccg ttgggcaagc tgcgggcgct tggtgtcaat cccgacgacg
325141 acaagccgtc gggcagctcc gacgaaacgt tggccgagct gattgcgcac agcagcaccg
325201 cgcccgcccc gaaggcgagc cgccgtgcgt cgatcatcat tttgaccagc ggcaccaccg
325261 gcaccccgaa gggggcgaac cgtaacacac cgccgacgct ggctccgatc ggcggcattt
325321 tgtcgcacgt gccgttcaag gccggcgagg tgacgctgtt gccgtcgccg atgttccatg
325381 cgctgggtta catgcacgcc gcgctcgcca tgttcctggg ctcgacgctg gtgctgcggc
325441 ggcggttcaa gcccgcgttg gtgctggaag acatcgaaaa gcacaaggcg acatccatgg
325501 tcgttgtacc agtgatgctg tcgcggatcc tcgaccagct ggagaaaacc gaacccaagc
325561 ccgacttgtc gagcttgaag atcgtgttcg tatccggatc gcaattgggt gccgagctgg
325621 ccacccgcgc gctgggggac ctcggcccgg tcatctacaa catgtacggc tcgaccgagg
325681 tcgcgttcgc caccatcgcc ggccccaagg atctgcagtt caaccccagc acggtggggc
325741 ccgtcgtcaa gggggtgacg gttaagatcc tcgacgagaa cggcaatgag gtgccgcagg
325801 gtgccgttgg ccggatcttt gtgggcaatg ccttcccgtt cgagggttac accggcggcg
325861 gtggcaagca gatcatcgac ggcctgttgt cgtccggcga cgtcggctac ttcgacgagc
325921 gcggcctgct gtatgtgagc ggccgcgacg acgagatgat cgtctctggt ggtgagaacg
325981 tgtttcccgc cgaagtcgag gatctgatca gcgggcatcc cgacgtggtg gaggccgccg
326041 cgatcggcgt cgacgataag gagttcggtg cccggctgcg cgcgttcgtg gtcaagaagc
326101 cgggagctga cctcgacgag gacaccatca agcagtacgt acgcgatcat cttgcccgct
326161 acaaggtgcc gcgggaggtg atcttcctcg acgagctacc gcgcaacccc accggcaagg
326221 tcctcaaacg tgagctacgc aagctgtagc tgctcgcgcg ggtacttacg ggtcgcgggg
326281 taggcccagc aaccgctcgg cgatgatgtt gagctggacc tccgacgtgc ccccgtagat
326341 ggtggtggcc cggctggcta gcaggtactc gccccacttg ccgggcaatc gctctgtgtc
326401 gccgatcacc gcatcggtgc caaaggacga caccgcgaat tcggcataac cctggccggt
326461 gcgcatggac aacagcttgg agatcgccgc cggcgccatc gggtcacccc cggccagcgt
326521 caacagcgtg gagcgcaagt tgagcagctt ggtggcgtgg ccctcggcga tcaattgccc
326581 ggcacggtgt cgcgcgacct ggtcgaactg tccttcgaaa cggtaatcgc gaacgaagtc
326641 gacgaactcg cccagggtgg ggaggaaggt cgaatcgctg ccgccgatcg acacccgctc
326701 ggccgtcagg gtgttgcggc tgacctccca cccccggttc acctccccga gcaccaactc
326761 gtcggggacg aacacgtcgt cgaggtagac ggtgttgaaa aactccttac ccgtgagctc
326821 gcgcagcggc ttcacttgta cgccttcgct tttcatgtcc agcaggaagt aggtgatgcc
326881 gttgtgcttg ggcgccgacg ggtccgtccg cgccagcagc gcaccccatt gggagtactg
326941 cgcgccggtg gtccagatct tctgaccagt gatgcgccag ccaccgtcga cccgggtggc
327001 cttggttgcc aggctagcca ggtccgatcc cgcgcccggc tcggagaaca gctggcacca
327061 gaaaatgtcg cctcggaacg ttggcggcag gaggcgctgc ttctgattgt cggttccgaa
327121 cgcgacgatc gacggcacga tccacgtcgc gatggcaatc tgcggccgct tgacccgccc
327181 ggcggtgaac tcctgggcga tgatgatctg ctcgaccggg ctggcggccc gaccccacgg
327241 cttgggcaga tatggcagca cccacccacc ttcggcgatc gcgacagtgc gcggctctcg
327301 cggcatcgcc ttcagcgcgg cgacttcggc ccggatctgg gcccgcagct tctcggtaga
327361 ggggtccagg tcgatgtcta ccggacgcat accggcagtc gtcgcggtgt ccaccacccg
327421 ctgcggatac tccgagccgc ggccaaagca cgcggccagc atcaacgccc ggcggtagta
327481 gacgttcgtg tcatgctccc aggtgaagcc gatgccgccg tgcacctgaa tgcagtcctg
327541 cgtgcagcgc tgagcggtcg ccggtgccag cgtcgccgcc accgccgccg cgaattcgac
327601 gtcggagcta gattcgcccg cgtcgtctaa ggctcgcgcc gcgtcccaca ccgcggcggt
327661 ggcccgctcg gtgtcagcga tcatctcggc gcacttgtgc ttgatcgcct ggaattgccc
327721 gatcggccgg ccgaattgtt cgcggatctt ggcatatgcc gacgcggtgt cggtcgccca
327781 ccgcgcgacg ccaacggctt cagcggacag cagggtggac atcagcgcgt gagcggtcgt
327841 catcgtgagg ttgctcagca gggcgtcgtc gctgacgtcg accgcgttgg cccgaacatg
327901 cgcgatgggc cgcaacggat ccaggctctt gaccgcttcg atctcgagct gatcgttgcg
327961 cagtacaacc cactcgtcac ggctttcgat ggccaccggt agcaccagaa cggaggcttg
328021 cgccgcggcc ggaaccgcgc ggacttcgcc ccggatcacc agcacgtcgc catggcgggt
328081 ggcggtcagc ccggaatcta gcgcgtaggc ggcgatggcc gcaccggttg ccagttcggc
328141 gaggactttg gcttgcggat catgggctgc gatcagcgcg ctggcgatcg ccgacggcac
328201 gaacggcccg ggcacggcgc cgtagccgaa ctcggcaagc accaccgcta gctcgaggat
328261 gccgaaaccc tggccgccga ccgactcggc cagatgcaca ccctgcaagc cttgttcggc
328321 cgcggcctgc cagtaaggcg gcgggttttc gaccggtgat tctagcgccg cgtgcagcac
328381 ctcggacggc gctacccgcg ccaccaggga acgcaccgaa tcggccagct cataatgctc
328441 aggagtaata gcgatcgaca ttgctcgcct tcccatgctg ttggacgttt cggccaagca
328501 ccttccaagc taacaaccgg tgggtcggtt attaacgttg gctagcggat ggccggcgaa
328561 atgggtgaga acactcagcg ccaccgcttg gctatccact tggcgatggt gtcggcctgc
328621 tcgctgcggg cgcccggggt ggtgaagtaa tggtcggtgt cgatcgagac ctgagtcttg
328681 tcgctgctgg cgagcccgtc gtagatctgc tgggcatccg acgggaagat tccggtgtcg
328741 gcctcggcgt tgagcaccag ggccgggcag gtgatccggg ccaggtgggg tgcggcacgg
328801 gtttgggcca cccgcaggct ccacatgccc agccagccgc gcagcgtgca ggccgcggcg
328861 atgccgtgtg cggagcggtt cgccttcacc ggcgtgcccg cgtagcactg gttgggccga
328921 cgcttggtcg gttcgatgct gggatcgacc atgcgcgggt cggcccaggt acgcatcacg
328981 ctgaacggcc gatcagaaaa gccagctgcg cgaacacgtt tgagttcgga ttcggcccag
329041 tcggtgatgg tgtggttgcg tttgacctgc gcggagcgat accggctgat aaactccggt
329101 gagtacggcg gcccgttgcg ttcgtcgaac aggtcaagtt cgggatcggt tgcaaccgga
329161 tcattttcgt caatgacggc ggcgtccatc caagcggtga gcacatccgg acggccggga
329221 tgagctgcgg cggcaacgta tgcgtcggcg gccggcaatt cggttacccc ggctgcgggt
329281 cgcataccgt ccaggggagt cacgttcgga tcgaccgctt gtgattggta ggcggccatc
329341 aatgagccac cacctgaatt gccaagcaac accactgttt ccacgccctg aacttcgcgg
329401 agccagcgca ccccgacgcc gatgtcgacc agtgcgtgat cgagcagaaa gctgctttcg
329461 aaaccacgga atcgggtgtt ccagcccaga aacccgatgc cgcggatcgc catgtactcg
329521 gcgagatagt gctcggagaa atcgatctgg tagtgcgcgg cgatgagcgc caccttcggt
329581 ttgcgtccca cgctgtggtg gtacagcccc tggcatgggt gcccaccggc agccgcacgc
329641 cccgcggttc gcgacggcag cccgacgaac tctcggatga ccccgggcgt ggcagcacga
329701 ccagtcaatt tgagctgtcc tccttactgt agatggcgcg gtagtaaatg ttggccaagg
329761 tctggatgca cgcctgatcg tcaggttgtc cacggcgtga acgcttaccg ctgagctgca
329821 ggtagcaaaa ctggttgaac attgccacaa tcgcctcggc catcaactgg gggtcatcgc
329881 cgacgcaata gccgtgcgcc tgagcgcgtt tgaccgtctc ggtgatgaac gatattggaa
329941 tctggcatat ttcggaccag tattgcgcga agtcgtcact gaccatcgcc aactgtgaca
330001 cgctgatcgc ttctgcgagg cggttgcggt aggtgtacca atgggcggca gcggcttcat
330061 acgcgcgctc gcggtcggat aggccgtgcc ggatcaccga caatgcccgc tggttggcgt
330121 cgtcgcggaa gcgcagcgcc cactgccgga ccatcgcctc tttggagtcg tagtagttgt
330181 aaaaggatgc cgccgagcgg ccggcttcgg cggtgatgtc ggcgacggtg gtcgccagga
330241 ttccgttgcg caccacgacc gtccgcgcgg cggcgtcgat tgcggcctgg gtccgccgac
330301 cgcgttgcgt cgggaagtcc ggcacctggg cacctccctg gaacaaaact gaacctgatg
330361 ttagattcag attcagagct tggccaggcc gccgtcccgg ggagccaatg ggagccgcac
330421 gatgatcaag ccgcacaaca ccaacaccga attcgagctt ggtgggatca accacgtcgc
330481 gctggtgtgt tcggacatgg cgcgcaccgt ggacttctac agcaacatcc tggggatgcc
330541 gctgatcaag gcgctcgatc tgcccggcgg ccaagggcag cacttcttct ttgacgccgg
330601 caacggcgat tgtgtcgcct tcttctggtt cgccgatgca cctgatcggg tgcccggtct
330661 ttcgtcgccg gttgccatcc ccggcatcgg cgacatcacc agcgcggtga gcaccatgaa
330721 ccatctggcg tttcatgtac ccgccgaaag gttcgacgcc taccggcagc ggctcaagga
330781 caaaggcgtg cgggtcggcc cggtgctcaa ccatgacgac agcgagacgc aggtgtccgc
330841 ggtggtgcat cccggtgtgt acgtacgctc gttctacttc caggaccccg atgggataac
330901 tctggaattc gcttgctgga caaaggaatt cactacgagc gacgcgcagg ccgtgccgaa
330961 gacggcggct gaccggcgac ctccggtggc tgcggatcgt tagccccgga tttggcagct
331021 gttgccgcta cccggggacg ggacaagttt gggtcggtga gttcatcgag cagcgcagct
331081 agctgatcga ccagctggtc gggatcgagt cgcacgtcac cggccagcca ggcgctgatg
331141 gtctgcccga cgccgccgac ggcgaagtgt gcgaccgcct tgacgtggtc atttgccggt
331201 gcgtgcaggg tgtcgacggc atgttggccg gacagcatgg cgaacagggc gctggattcc
331261 gcacgcttgc gggtgatcac tgcgttggcc agctgtgtgc tgaacagcag gcgtccgacg
331321 cgggcgtctg cggtgatggt ccgcacgatg ttggccatgc ccgcgcgagt ctgctcccgc
331381 gccggtaccg ccgtgaccgc ggcctgagtg gtggcgacca gctcggccac cacccagtcg
331441 aacacgcggc cgacgaattc gtccttgtcg gtgaagcttt cgtagaagta gcgcaccgac
331501 aggccggccc gccggcaaat ggtgcggatg gttagctcgg cgatgtcgtg ctggtcggac
331561 cccaacaggt ccaggccggc agagagcgac tggcgacggc gcgtcgccag tcgctcggcg
331621 gcctcgacgc cgcggtaggg tcgatcactg cgcgtcatac ggatcatctt gacactcggg
331681 cacgataccg gccaatatca ggatacaggt gtttccataa ttagcggcag cgccgggagg
331741 ccttcggatg gcgatttcgc tggtggctca ccagcccatc ccccacgtcg agcgtcccat
331801 ggccgaccca ccccgtctcc agctggccag gcgccggcga tcggcggccg gccccggcgg
331861 taacgaggac agcttgatgg gagtggcgct gctagccggc ccggccaacg tgatcatgga
331921 gttggcgatg ccgggtgtcg gctacggcgt gttggagagc cgtgtcgaaa gcggccggct
331981 ggaccgccat ccgatcaagc gggcgcgcac cacctttacc tacgttgcgg tggccgttgc
332041 cggcagcgac gaccagaagg cggcctttcg tcgcgcggtg aataaggttc acgcgcaggt
332101 gtattcgact ccggagagcc cggtgtccta ccacgcgttc gatcccgaac tacagctgtg
332161 ggtggcggca tgcctctata agggcggcgt cgacgtctac cgcaccttcg tcggcgagat
332221 ggacgacgaa gaggccgacc atcattaccg cgcgggcatg gcgatgggca ccacgttgca
332281 ggtgccgccg cagatgtggc caccggatcg ggcggccttc gaccgctact ggcggcaatc
332341 actggacagg gtgcacatcg atgacgtcgt tcgcgactac ctgtatccga tcgtggcgct
332401 ccgaattcgc gggatcgcac tgccgggtcc gctgcggcgg ctgtcggagg gtatcgcgct
332461 gctgatcacc accggtttcc tgccgcagcg gtttcgcgac gagatgcggt tgccgtggga
332521 cgcgaccaag cagcggcgct ttgacgcgct catggccgtg ctgcgcacgg tgaatcgcct
332581 gatgccgcgg tttgtccggg agttcccgtt caacctgatg ctctgggacc tggaccggcg
332641 gatgaggcgc gggcgcccgc tggtgtaatc gccggcttcg cgtggaccgt tgccggtaga
332701 ccgctcgcta gattggcggg cgaatatggc gcacagaggc aaaccgggcg aaatccctat
332761 ccaggctcac cacggcgcag tgatgctcca cggcgatggc cccgagtacc gcgtcaggta
332821 tcaagtcgcc cgatgcgtcg gcctcgtcgc agagttttcg cagcagcacc aggtgtctgg
332881 ggccggggct tgtcggaagg tgatggggct gggcgttgac ggcttcgacg aatgcgaatg
332941 catccgctcg tggtgacgga atctcgaaga tgcgtcgatt cgttgttagc cggaggaacg
333001 acgcccacac taggttcggc actgtgaagg ggtcgtcggc cgcaagcagt cgatcgaacc
333061 aggggcggac ggttcggtga ttcggatggt caccgcggtg tgcagccagc agcacgttga
333121 cgtcgatgag gaacatcgcc tatttgtgcc tgtccaggct cacttccgcg agttcagttc
333181 cagaccctcg tcgagcactt cggacaacac cgtattcgag gttaggtcga tacctggccg
333241 cggaccggtg ccggcgtcaa aaacggggac ggttggccgg gcgccgccgg tacgggcggc
333301 ggcgagctcc cgccgaaggg cgtcttcgat cacagcgccc agcgattaac cacgctcgcg
333361 ggcccggcgt ttggcggtag ccagtagttc atccgagatt gacacggtgg tgcgcatgat
333421 gctcaggata gcgcatctac ggcatcatct gcggtgagca actgatgccc tcaacgccgc
333481 gtgtggtcgc aggtctgcct gctatggcaa gccgttgagt ccgttctcgc cgagcagcag
333541 cccgccggtg ccgccggcac cgggcgtggc cccggctttg ccggcgttgc cgccgttgcc
333601 gccgttgccg atcagcacgg cgttgccgcc gacaccaccg ctgccgccgg taccggcgcc
333661 aaacccgccg gcaacccccg tcaccgccgt tgccgaacac cccggcgtgg ccaccgtcac
333721 cgccggtgcc gccggtaccg gcgcctagag cgttggcacc gctgccgccg gcgccgccgg
333781 cgccggcgga gccgaagagc aagccgccgt tcccgccggc gccgccggcg ccgccttgct
333841 ggatgctggt aagtgctgcc ccgccgtgcc cgccggcgcc gccggcgccg cggaagccga
333901 agagtaaggc gccgttcccg ccggttccgc cggccccgcc ggcaagggag ctggcgccac
333961 cgctgccgcc ggcgccaccg gaggcgccga gggagagtag gccggcgttg ccgccgtgcc
334021 cgccgccgcc ggtggtgatc ccggaccctc ccgagccggc ggcgccgccg gtgccgccgg
334081 ctccgaacag tccgccgttc ccgccgttcc caccggcccc gaagttcgtg ccggccccgc
334141 cggtgccgcc agttccgaac agtccgccgt tcccgccgtt cccgccggct gcgttgaacc
334201 cgccggcccc tccggctccg ccgttggcga acagtccgcc gttgccgccg gcgccgccga
334261 cgccggccgg gacaccgcca gcggcgccgt ggccgccggt gccggccgcg ccgaagagca
334321 aaccggcgtc gccgccgcgc ccgccggccc cgccgatgcc agcgacgcct atggagttcc
334381 caccgttgcc gccggtgccg ccggagccga tcagcaagga gaccccaccg gcgccgccgg
334441 ccccgccgat ccctccagca ccggtggcta tcccgccggt cccgccattg ccaccggtac
334501 cgaacaagat cccgccggcc ccgccggccc cgcccgtagc cgtggcggcg gtgttggtcg
334561 caccgtgccc gccgttaccg ccgttgccga acaaccaccc gccggccccg ccggcagccc
334621 cggtccccgg ggtcccgttg gcgccgttgc cgaacagcca cccgccggcc ccgccgtcag
334681 ccccggttcc aggagtcccg ttggcgccgt tgccgatcag cgggcggccg gtgagcgtct
334741 ggaagggctc gttcaccaca ttgagcacat tttgctgcag ggtgtgcagt ggcgaggtgc
334801 tcgcgggagc attgaatccg tctagaccga gcagcagccc gctgacgccg cccactccgg
334861 ccttgcccgc gccaatccca ccgctaccgc cgttaccgcc attgccgatc aacacgccgg
334921 tgccgccgat cccgccgttg ccgccggtca ccgcgctggc gccaccgtta ccgccgttgc
334981 cgccgttacc gatcagcccg ggggtgccgc cagccccacc gatcccgccg gcgaagccct
335041 ggccaactcc gccgttgccg ccggcgccgc cggagccgaa gaccgtgccg gcgttgcccc
335101 cggggccgcc ttgcccgccg tcggcgaagc cgaatccgcc ggcgccgccg gagccgccgg
335161 agccgaagag cagcccagcg ttgccgccgg cgccgccggc gccgcctatg ccgccggccg
335221 tgagagtacc gccgtcccca ccgattccgc cggcgccgcc cgcggcgccg agggcgagca
335281 tgccggcatt gccgccggcc ccgccgtccc cgccggcgac caggctgtgt ccgccgctgc
335341 cgccttcccc gcctgcgccg aacagcccgc cggccccgcc ggccccgccg actccgccga
335401 agctgctgtc ggcgaacccg ccatgcccgc cggtgccgcc ggcgccgaac agcccgccag
335461 cgccaccggc cccaccggcc ccgccggagc tgccggcccc accggatccg ccgaccccgc
335521 cggtggcgaa cagcccgccg gccccgccgg cgccgcccgc cccgccgagt gcactgccgt
335581 tcgtgaatcc gccggccccg ccgactccgg cggcgccgaa gagcaggccg gcgttgccgc
335641 cagccccgcc ggcgccgccg gccccgcccg tgagggctac tacgccgccg ccggcgccgc
335701 cggcgccgcc ggcgccgaac agcatggcgt tgccgccggc tccgccggac ccgccgatcc
335761 cactgctggc gaccccgcca gcgccgccgg cgccgccgtt gccgatgagc ccgccggcgc
335821 cgccgttgcc gccggcgccg ccgttgccgc cggcgccgcc gttgacgccg gccgcgccgg
335881 atcctccggc gccgccgttg ccgattaacc agccgccgtc cccgccattg gccccggtgc
335941 cgggggcgcc gttggcgccg ttgccgatca acgggcgccc ggtattcgcc aggaagaact
336001 cgttgatcgg atccagcagc ggcgacaccg cggcggcctc ggcggccgca taggcgccgc
336061 caccggaggt caatgcctgc acgaactggg catgaaacgc ctgcgcttgg gcgctgagcg
336121 cctgataggc ctggccgtgg gcgccgaaca gcgcggcgat ggctgtcgac acctcgtcgg
336181 cgcccgcggc catcagtgcc gtggtgttgg ccgccgcggc tgcgtttgcc gcgctgatgc
336241 tcgatccgag actggccaaa tccgttgccg ctgccgcgat aacctctggc gccgcaatca
336301 caaacgacat ctgacacctc ccaatacgca tgaccgctct gtcatgccga cccggggaac
336361 gtcaccagca aaaatcggca gtaagaagca tcccatttcc agcgacaaca cctggggggt
336421 tttggtcaaa ctctggtaag cgacttcgtg taccgggtga acccggtgtg tcttgaagga
336481 cagcccgcag gctgatgctg ggggatctgg gccggccgac catggctggc cggctgttgg
336541 tctgatggcc ggttcgcggt tacaggccgt tgagcccgtt ctcgccgatg atcagcccgc
336601 tggtgccgcc ggcgccgggt gtgccgccgg ctttcccgcc gttgccgccg ttgccgccgt
336661 tgccgatcag cacggcgttg gggaccgagc tcgaattccc accggtgtca gcgccaaacc
336721 cgccggcgcc gccgtcgccg ccgttgccga acaccccggc cgtaccgccg tcaccgccgg
336781 tgccgccgct gctgccgatg ccgctggagc caccggtgcc gccggcaccg ccgaagccga
336841 agagcgagcc gccactgccg ccgttcccgc cgaccccgcc ggtcccgccg acatttaagg
336901 cgctgccgcc gctgccgccg gcgccgccgg aggcgccgag ggcgagtagg ccggcgttgc
336961 cgccgctgcc gccgttgccg ccgaaggtgc cgccgctgct gccgccagca ccgccagtgc
337021 cgccggcgcc gaacagcccg ccgtgccccc cggcgccgcc gtcggcgccg agcgtgcccg
337081 ccccgccggt gccgccggcg ccgaagagca atccgttccc cccggtcccg ccattcgcgc
337141 caaacccgcc ggccccgccg gccccgccgt tggcgaacag cccaccggta ccaccggctc
337201 cggcggtgcc gccggcaccg ataaagtttt gggagagggc ggcctggccg ccggtccctg
337261 cggcaccgag gaacaagccg gcgtcaccgc cgcgcccgcc ggccccgccg gtgtccaggc
337321 caaacccgcc gctgccgccg gtgccgccgg agccgatcag caaggcggct ccgccggtcc
337381 cgccggtccc gccttggccc gtcgttccga tgccgccgga cccgccggtg ccgccaatac
337441 ctgacaggat tccgccggcc ccgccggatc cgccgtctcc gccgtcggcg ccggtcgctc
337501 cgtggccgcc gttgccgccg ttgccgaaca accacccgcc ggccccaccg tcggccccgg
337561 tccccggagt gccgttggcg ccgttgccga tcagcggtcg cccggtgagg gcttgggtgg
337621 gctcgttgat cgcgttgagg atttgttgct gcagggtgtg cagtggcgtg ctggcggggg
337681 cgttgaatcc gtctcgacct agtagctgcc cgcctaagcc gccggcgccg gccgtgccgg
337741 cgggtgcgcc agtgccgcca ctaccaccgt taccgccatt gccgatcagc acgccgcttc
337801 cgccggcgcc gccggcggcg ccggcgccgt tcgcgctggc gccgccgttg ccgccgttgc
337861 cggcgttgcc gacgagcccg ggcgcgccgc cggccccacc ggttccgccg gcgcccgcga
337921 aggacccgcc gccggcgccg ccggcaccgc ccgccccgat gagcagaccc gcctttccgc
337981 cggcgccgcc cgccccgccg gcgtcgaagc ccagcccgca gacgccgccg gcgccgccgg
338041 agccgaacaa cgtgccgccg tcgcctccga tcccaccggc accgccgcca ccgtccgggt
338101 tggatccgcc gctgccgccg gcgccgccgg cggcaccgag gctgagcatg ccggcgtcgc
338161 cgccggcccc accgttcccg ccgacgttga ttatgctcgt cccgccacta ccgccggtgc
338221 cgccggcgcc gaacagcccg ccagagccgc catccccgcc ggcgccgccg ccaaagatgc
338281 cgaatccgcc gggcccaccg gtgccgccgg cgccgaacag cccgccgttt ccgccggatc
338341 cgccggcccc gccggtgccg gcgtcggttg ccccgccggc gccaccgacc ccgccgtcgg
338401 cgaacagccc gccgtttccg ccggccccgc cggcgccgcc ggtggcgccg aaagcggctg
338461 cgaatccgcc gggaccgccg accccggcgg ccccgaacag catgccggcg gccccgccgg
338521 cgccgccggc gccgccggtc cccgtgctgg ccctcccgcc ggcgccgccg gcgccgccgt
338581 tgccgatgag cccgccggcg ccgccgttgc cgccggcccc gccgttgacg ccggccgcgc
338641 cggatcctcc ggcgccgccg ttgccgatta accagccgcc gtccccgcca ttggccccgg
338701 tgccgggggc gccgttggtg ccgttgccga tcagcgggcg cccggtattc gccaggaaga
338761 actcgttgat cggggcgagc agcggcgagg tggcggcggc ctcggcggcg gcgtacgcgc
338821 cgccaccgga ggtcaacgcc tgcacgaact gggcatgaaa cgcctgcgct tgggcgctga
338881 gcgcctgata ggcctggccg tgggcgccga acagcgccgc aaccgccgtc gagacttcat
338941 cggcacccgc ggccagcagt gctgtggtgt tggccgccgc ggccgcgttg gccgcggcga
339001 tgctcgactc gagactggct aaatccgttg ccgctgccgc gataacctct ggcgccgcaa
339061 tcacaaacga catctgacac ctcccaatac gcatgaccgc tctgtcatgc cgacccgggg
339121 aacgtcacca gcaaaaatcg gcgggctaca gaataactcc ggcccgggaa agggatttgg
339181 tatttcccaa aatatctccc acatttatgc ggtcggcgcg tcggccgacg ggagctggca
339241 gcacccgtgg gccggcgccg agcgttcgct ggtgtccggc tgggacttgc attgcggcgc
339301 gccgtggtgt ggaatagtgg taatgaaaat catgttcatc agtcctctgt ggtgtttacg
339361 gctatgacgc tgtggatggc ctcgccgccc gaggtgcatt cggcgttgct cagcagcggg
339421 ccggggccgg gctcggtgtt gtcggcggcc ggggtgtggt cgtcgctgag cgccgaatac
339481 gccgcggtcg ccgacgagct catagggctg ctgggcgccg tgcagaccgg cgcttggcag
339541 gggcccagcg ccgcggctta tgtggccgcc cacgcgccgt acctcgcgtg gttaatgcgg
339601 gccagcgaaa ccagcgcgga agcggccgcc cggcacgaga ccgtggccgc ggcctacacg
339661 accgcggtgg cggccatgcc gacgttggtc gagctggccg ccaaccacac gcttcacggg
339721 gtcttggtgg cgacgaactt cttcggcatc aacaccatcc cgatcgcgct caacgaggcc
339781 gactacgcgc ggatgtggac gcaggccgcc agcacgatgg cgacctatca agcggtcgcc
339841 gaggccgcgg tggcgtcggc accgcagacc accccggcgc cgccgatctt ggcagccgaa
339901 gcggccgacg atgaccacga tcatgaccac gatcacgggg gcgaaccgac cccgctggac
339961 tatctggtcg cggagatatt gcgcatcatc agcggtgggc gcctgatctg ggatcccgcc
340021 gagggcacca tgaacggaat cccgttcgaa gattatacgg acgcagccca accaatctgg
340081 tgggttgttc gtgccatcga attcagtaag gactttgaaa cgtttgttca ggaactgttt
340141 gtcaatccgg tggaggcatt tcagttctac tttgagcttc tattgttcga ctacccgacc
340201 cacattgtgc agattgttga ggcgttgagc cagtccccgc agttgctggc ggtcgcactc
340261 ggttccgtca tctccaactt gggtgcggtg accgggttcg ccgggctatc cggcttggcc
340321 ggcatgcagc cggcggctat cccggcgcta gcacccgtcg cggcggcccc gtcgacattg
340381 ccggcggtcg cgatggcccc gaccatggcc gcgccgggcg cggcggttgc gtcggcagcc
340441 gcgccggcgt ccgcgccggc ggccagcacg gtggccagcg ccacgccggc accgccgccg
340501 gcacccggcg ccgccgggtt cggctatccc tacgccatcg ctccgcccgg catcgggttc
340561 ggctcgggga tgagcgccag cgccagcgct caacgcaagg caccacagcc cgatagtgcg
340621 gcggcggcgg cggccgcggc ggccgtacgt gaccaagcgc gggcgcggcg gcggcgccgt
340681 gtcacgcggc gcggatacgg cgacgagttt atggatatga acatcgacgt cgatccggac
340741 tggggccctc cgcccggcga agacccagtc acatccacgg tggcctcgga tcggggtgcc
340801 ggacatctgg gctttgccgg gacggcccgc agggaggcgg ttgccgacgc ggccgggatg
340861 accacgctgg ctggcgatga tttcggcgac gggccaacga cgccaatggt gccgggttcg
340921 tgggatccgg accgggatgc gcctggctcg gcggagcctg gagatcgggg ctgagctagc
340981 cgcgtagggt cgattgggtg cgtaccgaag gtgatagctg ggacatcaca acgagtgtcg
341041 gttcgaccgc gctgtttgtc gcgacggcgc gagcgctgga agcccagaag tccgacccgc
341101 tggtcgtcga cccatatgcg gaggcgttct gccgtgccgt cggcggttcg tgggccgatg
341161 tgctcgacgg caagcttccc gaccacaagt tgaagagcac cgatttcggc gagcacttcg
341221 tcaacttcca gggtgcccgc accaagtatt tcgacgagta tttccgtcgg gccgccgccg
341281 ccggcgcgcg gcaggtggtc atcctggcgg cggggctgga ctcgcgcgcg taccggctgc
341341 cttggcccga cgggaccacg gtttttgagc tggaccgccc gcaggtcctt gatttcaagc
341401 gcgaggtgct cgccagccac ggtgcccaac cgcgcgccct gcgccgcgag atcgccgtcg
341461 acctgcgtga cgattggcca caagccttgc gggacagtgg tttcgatgcg gctgcaccgt
341521 cggcatggat tgccgaaggg ctgctgatct atctcccggc caccgcccag gagcggctat
341581 tcaccggcat cgatgccctg gccgggcgcc gaagccacgt cgccgtcgag gatggtgccc
341641 caatggggcc agacgaatat gcggctaagg tcgaagagga gcgcgccgcg atcgccgagg
341701 gagccgagga gcacccgttt tttcaactgg tctacaacga gcgatgcgcg ccggccgccg
341761 agtggttcgg cgagcgaggt tggaccgcgg tcgctacgct gttgaacgac tacctcgaag
341821 cggtgggtcg cccggtaccc ggaccggaat ccgaagccgg gccgatgttc gcccgcaaca
341881 ccctggtcag tgccgcccgc gtctgacggc gcaccgttcg cgctgccggc accccgggct
341941 ccataatgaa aatcatgttc agtaagctac actctgcata tcgggctacc aacgaaatgg
342001 agtatcggtc atgatcttgc cagccgtgcc taaaagcttg gccgcagggc cgagtcgatt
342061 ggtcgcggtc gcctcgacag ttagcttatg caatgctaac ttcggggcaa agttcaggcg
342121 gatcggccga tggcgggcgt aggtgaagga gacagcggag gcgtggagcg tgatgacatt
342181 ggcatggtgg ccgcttcccc cgtcgcgtct cgggtaaatg gcaaggtaga cgctgacgtc
342241 gtcggtcgat ttgccacctg ctgccgtgcc ctgggcatcg cggtttacca gcgtaaacgt
342301 ccgccggacc tggctgccgc ccggtctggt ttcgccgcgc tgacccgcgt cgcccatgac
342361 cagtgcgacg cctggaccgg gctggccgct gccggcgacc agtccatcgg ggtgctggaa
342421 gccgcctcgc gcacggcgac cacggctggt gtgttgcagc ggcaggtgga actggccgat
342481 aacgccttgg gcttcctgta cgacaccggg ctgtacctgc gttttcgtgc caccggacct
342541 gacgatttcc acctcgcgta tgccgctgcg ttggcttcga cgggcgggcc ggaggagttt
342601 gccaaggcca atcacgtggt gtccggtatc accgagcgcc gcgccggctg gcgtgccgcc
342661 cgttggctcg ccgtggtcat caactaccgc gccgagcgct ggtcggatgt cgtgaagctg
342721 ctcactccga tggttaatga tcccgacctc gacgaggcct tttcgcacgc ggccaagatc
342781 accctgggca ccgcactggc ccgactgggc atgtttgccc cggcgctgtc ttatctggag
342841 gaacccgacg gtcctgtcgc ggtcgctgct gtcgacggtg cactggccaa agcgctggtg
342901 ctgcgcgcgc atgtggatga ggagtcggcc agcgaagtgc tgcaggactt gtatgcggct
342961 caccccgaaa acgaacaggt cgagcaggcg ctgtcggata ccagcttcgg gatcgtcacc
343021 accacagccg ggcggatcga ggcccgcacc gatccgtggg atccggcgac cgagcccggc
343081 gcggaggatt tcgtcgatcc cgcggcccac gaacgcaagg ccgcgctgct gcacgaggcc
343141 gaactccaac tcgccgagtt catcggcctc gacgaggtca aacgccaggt gtcgcggctg
343201 aagagctcag tggccatgga actggtccgc aagcagcgtg ggctcacggt cgcccaacgc
343261 acgcaccact tggtgtttgc gggaccgccc gggaccggca agaccaccat tgcccgggtg
343321 gtcgccaaga tctattgcgg ccttggcttg ttgaagcggg agaacatccg cgaggtccat
343381 cgcgccgacc tcatcggcca acacatcggc gagaccgagg cgaaaaccaa cgcgatcatc
343441 gacagcgcgc tggacggggt gctgttcctc gacgaggcct acgccctggt ggccaccggc
343501 gccaagaacg acttcgggtt ggtggccatt gacaccttgt tggccaggat ggaaaacgac
343561 cgcgaccggc tggtggtcat catcgccggc tatcgcgccg acctggacaa attcctggac
343621 accaacgagg gacttcggtc gcgtttcacc cgcaacatcg actttccctc ctacacgtcc
343681 catgagctgg tggagatcgc gcacaagatg gccgaacagc gagacagcgt cttcgaacag
343741 tccgcgctgc acgatttgga ggcgttgttc gccaagttgg cggcggagtc gacaccagat
343801 accaacggaa tctcgcgacg tagcctcgac atcgcgggca atggtcggtt tgtgcgcaac
343861 atcgtcgaac gctccgaaga agagcgtgaa ttccggctgg accattccga acatgccgga
343921 tccggtgagt tcagcgacga ggagctgatg accatcacgg ccgacgacgt gggtagatcg
343981 gtagagccgc tattgcgtgg cctcgggctc tcggtgcggg catgacgaac cagcagcacg
344041 accacgactt cgaccacgac cgtcgctcgt tcgcctcccg aaccccggtc aacaacaacc
344101 ccgacaaggt tgtctaccgc cgcggcttcg tcacccgcca tcaggtgacg ggctggcggt
344161 tcgtgatgcg ccgaatcgcc gccggaatcg cattgcacga cacccgcatg ctggtcgacc
344221 cgttgcgcac tcagtcacgc gcggtgctga tgggtgtgct gattgtgatc acggggttga
344281 tcggctcctt cgtattctcg ttgattcggc ccaatgggca ggcgggtagc aacgcggtgc
344341 ttgccgaccg gtccaccgcg gcgctgtatg tgcgggtggg cgagcagctg cacccggtgc
344401 tcaacctgac ctcggcccgg ctgatcgtcg gccggccggt gagcccgacg acggtgaaaa
344461 gtactgagtt ggaccagttt ccgcgcggaa acctgatcgg catcccgggt gcgccggagc
344521 ggatggtgca gaacacctcc accgacgcga actggacggt gtgtgacggc ctcaacgcac
344581 cgtcgcgggg cggtgcggat ggcgtgggtg tgacggtgat tgccggcccg ctggaggaca
344641 ccggcgcacg cgcggccgcg ctcgggcccg ggcaggcggt gctggtcgac agcggcgccg
344701 gcacctggct gttgtgggac ggcaagcgca gcccgattga tctggccgat catgcggtca
344761 ccagcggcct cggcctgggc gccgacgtgc ccgcgccgcg gatcatcgcc tcggggctgt
344821 tcaacgcgat acccgaagca ccgccactga cggcgccgat catcccggat gccggcaacc
344881 cggcgagctt cggtgtgccg gcgccgatcg gcgcggtggt gagttcctac gccctgaaag
344941 actcgggcaa gaccatatcg gacaccgtgc agtactacgc ggtgctgccg gacggtttgc
345001 agcagatttc gccggtattg gcggcaatcc tgcgcaacaa caactcctat ggtctgcagc
345061 agccgcctcg gctgggggcc gacgaggtcg ccaagctgcc ggtgtcgcgg gtgttggaca
345121 ccaggcgcta tcccagcgag ccggtaagtc tcgtcgacgt tacccgtgac cccgtcacct
345181 gcgcgtactg gagcaagccg gtgggtgcgg ccaccagctc gttgactctg ttggcaggct
345241 cggcgctgcc ggtgccagat gcggtgcaca ccgtcgagct ggtcggcgcc ggcaacggtg
345301 gtgtggcaac ccgagtggcg ttagcggccg gtactggcta cttcacccag acggtgggcg
345361 gcggcccaga tgcgccgggc gccgggtcgt tgttctgggt gtcggatacc ggggtgcgtt
345421 acggtatcga caatgagcct cagggagtgg ctggaggcgg caaagcggtt gaggcccttg
345481 gcctgaaccc gcccccggtc cccatcccgt ggtcggtgct gtcgctgttt gtgcccggcc
345541 cgacgctgtc gcgtgccgac gcgctgctgg cacacgacac cttggtgccc gacagcaggc
345601 ccgctcgtcc ggtatcggcc gagggagggt accggtgagc agactgatct ttgaggctcg
345661 tcgccgactg gcgccgccga gcagccacca gggcaccatc atcatcgagg cgcctcccga
345721 gctgcctcgg gtgatcccac cgtcactgct acgacgagcg ctgccttatc tgatcgggat
345781 cctcatcgtg gggatgatcg tggcgctggt cgccaccggg atgcgggtga tttctccgca
345841 gacgttgttc ttcccatttg tgctgctgtt ggcggccacc gcgctctacc gcggcaacga
345901 caagaagatg cgcaccgagg aggtcgacgc cgaacgggcc gactacctac gttacctatc
345961 ggtggtgcgg gacaacattc gggcccaggc cgccgagcag cgggccagcg cgttgtggtc
346021 tcatcctgac ccgacggcgt tggcgtcggt gccggggtca cgtcgccaat gggagcgtga
346081 cccgcacgac cccgactttt tggtgttgcg ggccggccgg cacacggtac cgctggctac
346141 tacgctgcga gtcaacgaca ccgccgacga gatcgacctg gaaccggtgt cgcacagtgc
346201 attacgcagc ctgctcgaca cccagcgcag cattggcgac gtgccgaccg ggatcgacct
346261 gaccaaggtt tcgccgatca ccgtgctggg ggagcgcgca caggtgcgcg cggtgttacg
346321 cgcctggatc gctcaggcgg tgacctggca cgacccgacg gtgctcgggg tggcgctggc
346381 cgcgcgtgat ctggagggtc gcgattggaa ctggctgaag tggttaccgc acgtggacat
346441 tcccggccgc ctcgatgcgc tgggcccggc ccgcaatctg tcgaccgatc ccgacgagct
346501 catcgcgctg ctggggcccg tcctggcaga ccgcccggcg tttaccgggc agccaacaga
346561 tgcgttgcgg cacttgctga tcgtcgtcga tgacccggac tacgacctgg gcgcatcgcc
346621 gctggcggtg ggccgcgcgg gtgtcaccgt cgtgcactgc tcggccagtg cgccgcaccg
346681 ggaacagtat tcggatccgg aaaagccgat cctgcgggtg gctcacggcg ctatcgaacg
346741 ctggcagaca ggcggctggc agccctacat cgacgccgcc gaccaattca gcgctgatga
346801 ggccgcccac ctggcgcgcc gactgtcgcg gtgggactcc aaccccaccc atgccgggct
346861 gcgctcggcg gccactcgcg gcgcgagttt caccacactg ctgggcatcg aggacgcatc
346921 ccgactggat gtgcccgcgc tgtgggcgcc gcgacgacgc gacgaggagt tacgcgtgcc
346981 gatcggtgtc actggcaccg gcgagccgct gatgttcgac ctcaaagacg aagccgaggg
347041 cgggatgggc ccgcacgggc tgatgatcgg catgaccggt tcgggcaagt cgcagacttt
347101 gatgtcgatt ctgttgtcgc tgttgaccac acactccgcg gagcggctca tcgtcatcta
347161 cgccgacttc aagggtgagg ccggcgccga cagtttccga gatttcccgc aggtggttgc
347221 ggtgatctcg aatatggccg agaagaagtc gttggctgat cggttcgccg acacgctgcg
347281 cggcgaggtg gctcgtcgcg agatgctgct gcgtgaggcc ggccgcaagg tccagggcag
347341 cgcgttcaac tcggtgctcg agtatgaaaa cgccatcgcc gcagggcata gcctgccgcc
347401 catcccgaca ctgttcgtgg tcgccgacga gttcaccttg atgctggccg atcacccgga
347461 atacgcggag ctgttcgact atgtggcccg caagggtcgc tcgtttcgca tccacatcct
347521 attcgcgtcc cagacactgg acgtgggcaa gatcaaagac atcgacaaga acaccgccta
347581 tcggattggg ctgaaagtgg ccagccccag cgtttctcgc cagatcatcg gcgtggagga
347641 cgcctaccac atcgagtcgg gcaaagaaca caaaggcgtg ggctttttgg tgcccgcgcc
347701 cggtgccacc ccgataaggt tccgcagcac ctatgtcgac gggatctatg aaccgccgca
347761 gacggctaaa gccgttgtcg tgcaatccgt tccggagccc aagctgttca ccgccgccgc
347821 ggtggaaccg gatccgggca cggtgatcgc cgatactgac gaacaagaac ccgccgaccc
347881 accacgcaaa ctgatcgcga ccatcggcga acaactggcc cgctacggtc cgcgggcgcc
347941 gcagttgtgg ctgccgccac tcgacgaaac gatcccactg agcgcggcgt tggcccgcgc
348001 cggggtgggc ccccggcagt ggcgctggcc gctgggggag atcgacaggc ccttcgagat
348061 gcggcgcgac ccgttggtgt ttgacgctag gtcgtcggcc ggaaatatgg tgatccacgg
348121 cggccccaag tccggcaaat ccactgcgct gcagacattc atcctctcag ctgctagcct
348181 gcactcgccg cacgaggtta gcttctattg cctggactac ggcggtgggc agctgcgggc
348241 gctacaggat ctagcgcacg tcggcagtgt cgcctcagcg ctggaacccg aacgcatccg
348301 ccgcaccttc ggcgagctcg agcaactgct gttgtcccgg cagcagcggg aagtattccg
348361 tgaccggggt gctaatggct cgacccccga cgacgggttc ggtgaggtgt tcctggtcat
348421 cgacaatctc tatggcttcg gccgcgataa caccgatcag ttcaacaccc gtaatccgtt
348481 gctggccagg gtaaccgaac tggtcaacgt gggccttgcc tacgggatcc acgtgatcat
348541 taccacgccg agctggctgg aagtgccgtt ggcgatgcgc gacgggctcg ggctgcgtct
348601 cgagctgcga ctgcacgacg cgcgcgacag caacgtgcgg gtggtcggcg ccctgcgccg
348661 cccggccgac gccgtcccgc acgaccagcc cggccgcgga ctgaccatgg ccgccgagca
348721 cttcctgttc gcggctccag aactggacgc gcaaacaaac ccggtggccg cgatcaacgc
348781 ccgctacccc ggcatggcgg ctcccccggt tcggttgttg cccaccaacc ttgcgccgca
348841 cgccgtcggc gaactgtatc ggggtcccga ccaactggtg attggccagc gcgaagaaga
348901 cctggcgccg gtgatactcg acctcgccgc caacccgctg ctgatggtgt tcggcgatgc
348961 caggtcagga aagacgacgc tgctgcgcca catcatccgc accgtccgcg agcactccac
349021 cgccgaccgg gtcgcgttca ccgtgctgga ccgccggcta cacctggtcg acgaaccact
349081 gttccccgac aacgagtaca ccgccaacat cgatcggatc atcccggcga tgctcgggct
349141 ggccaacctc atcgaggcgc gccggccgcc ggccgggatg tctgcggccg agctgtcccg
349201 ctggaccttt gccgggcaca cccactacct gatcatcgac gacgtcgacc aggtaccgga
349261 ttcgccggcg atgaccggtc cctacatcgg acagcggccg tggaccccgc tgatcggtct
349321 cctggcccag gccggcgact tggggctacg ggtgattgtc accgggcgtg ccactggatc
349381 ggcgcacctg ctgatgacaa gtccgttgct gcgccggttc aacgacctgc aggcgaccac
349441 gctgatgttg gcaggcaatc cggccgacag cggcaagatt cgcggtgagc ggtttgcccg
349501 attgcctgct ggacgagcaa ttctgttgac cgacagtgat agtccaacct acgtgcagtt
349561 gatcaacccg ctggtcgatg cggccgcggt ttctggtgaa acccaacaga aggggagtca
349621 gtcatgacgt tgcgagtggt tccggagggg ctggccgcag ccagcgctgc ggtggaagcg
349681 ctgacggcgc ggttggccgc cgcgcatgcg agcgcagcgc cggtgattac cgcggtagtg
349741 ccgccggcgg cggatccggt gtcgctgcag accgcggccg ggttcagtgc acagggcgtc
349801 gagcacgcgg tcgtcaccgc cgaaggtgtc gaagagctgg gacgcgccgg cgttggtgtg
349861 ggcgaatccg gcgccagcta cctggccggt gatgcggccg ccgccgctac gtacggggtc
349921 gtgggcggct gagcatggcc gcgcccatct ggatggcttc gccgccggag gtacattcgg
349981 cgttgcttag caatggtccg ggcccgggtt cgctagtggc ggctgccacg gcctggagcc
350041 agctgagtgc cgagtatgcc tcgacggcag cagaactcag tgggctactg ggggcggtac
350101 ctggttgggc atggcagggg cccagcgcgg agtggtacgt ggccgcgcat ttgccatatg
350161 tggcgtggct gacgcaggcc agtgcggatg ccgcaggagc agcggcccag cacgaggccg
350221 ccgcggcggc ctacaccact gccttggcag ccatgccgac attagcggag ttggccgcca
350281 accacgtgat tcacaccgtg ttggtggcga cgaatttctt tgggatcaac acgattccca
350341 tcacgctcaa tgaggccgat tacgtgcgca tgtggttgca ggcggccgcc gtcatgggtc
350401 tttatcaggc ggcttcgggt gcggcactgg cttcggcgcc gcgcaccgtc ccggcgccga
350461 cggttatgaa tccaggtggc ggtgcggcga gcactgtcgg ggcggtcaac ccctggcagt
350521 ggctcttagc gttgcttcaa cagctctgga acgcctacac gggtttctac gggtggatgt
350581 tgcagctcat ctggcagttc ctgcaggatc ccattggtaa ctcgatcaag atcatcatcg
350641 ccttcctcac gaatcccatt caggcactga tcacttacgg gccgctgttg ttcgcgctgg
350701 gctaccagat tttcttcaac ctggtcggct ggccgacctg gggcatgatc ttgagctcgc
350761 cgttcttgtt gccggccggg ctcgggctgg gcttggcagc aatagccttt ctacctattg
350821 tgcttgcgcc cgcggtgatt ccgccggcga gtactccgct ggctgctgcc gccgtcgccg
350881 ccgggtcggt gtggccggcg gtcagcatgg ccgtaacggg ggcgggcacc gctggggctg
350941 cgacgcccgc ggcgggcgcg gctccgtctg cgggcgcagc gccggccccg gcagctcccg
351001 cgaccgccag tttcgcctat gcggtgggtg gcagcggtga ttgggggccg agcttggggc
351061 cgacggtagg tggtcgcggt ggtatcaagg cgccggccgc tacggttccg gcggcggccg
351121 cggcggcggc aactcgtggg cagtcgcgcg cgcggcggcg ccggcggtct gaattgcggg
351181 actacggcga cgagttcttg gacatggatt ccgatagcgg tttcggcccc tcgacgggcg
351241 accacggcgc gcaggcctcc gaacgggggg ccgggacgct gggattcgcc gggaccgcaa
351301 ccaaagaacg ccgggtccgg gcggtcgggc tgaccgcact ggccggtgat gagttcggca
351361 acggcccccg gatgccgatg gtgccgggga cctgggagca gggcagcaac gagcccgagg
351421 cgcccgacgg atcggggaga gggggaggcg acggcttacc gcacgacagc aagtaaccga
351481 attccgaatc acgtggaccc gtacgggtcg aaaggagaga tgttatgagc cttttggatg
351541 ctcatatccc acagttggtg gcctcccagt cggcgtttgc cgccaaggcg gggctgatgc
351601 ggcacacgat cggtcaggcc gagcaggcgg cgatgtcggc tcaggcgttt caccaggggg
351661 agtcgtcggc ggcgtttcag gccgcccatg cccggtttgt ggcggcggcc gccaaagtca
351721 acaccttgtt ggatgtcgcg caggcgaatc tgggtgaggc cgccggtacc tatgtggccg
351781 ccgatgctgc ggccgcgtcg acctataccg ggttctgatc gaaccctgct gaccgagagg
351841 acttgtgatg tcgcaaatca tgtacaacta ccccgcgatg ttgggtcacg ccggggatat
351901 ggccggatat gccggcacgc tgcagagctt gggtgccgag atcgccgtgg agcaggccgc
351961 gttgcagagt gcgtggcagg gcgataccgg gatcacgtat caggcgtggc aggcacagtg
352021 gaaccaggcc atggaagatt tggtgcgggc ctatcatgcg atgtccagca cccatgaagc
352081 caacaccatg gcgatgatgg cccgcgacac ggccgaagcc gccaaatggg gcggctagct
352141 cgcgctacat ggatgcaaca cccaacgccg tcgagctgac ggtcgacaac gcttggttca
352201 tcgctgaaac cattggggcg gggacctttc cgtgggtgct ggcgatcacg atgccctata
352261 gtgatgccgc ccagcggggt gcgttcgtcg accgtcagcg cgacgagctg acccggatgg
352321 ggctgttatc gccgcagggt gttatcaacc ctgcggtcgc cgactggatc aaagtggtgt
352381 gcttcccgga ccgctggctt gacctgcgtt atgtggggcc ggcctcggcc gacggcgcct
352441 gcgagctgct acgtggcatc gtcgcgctgc gcaccggcac cggtaagacc tccaacaaga
352501 ccggaaacgg tgttgttgcg ctgcgtaatg cgcagctggt cacgttcacc gcgatggata
352561 tcgacgaccc ccgggcgctg gttccgattc ttggtgtcgg tttggcgcac cggccgccgg
352621 cgcggttcga cgagttcagc ttgccgacgc gggtgggcgc gcgggccgac gaacggctgc
352681 ggtccggcgt gccactcggg gaagtcgttg actatctggg tattccggcg tccgcacggc
352741 cggtggtgga gtccgtcttc tcggggccgc gcagctacgt cgagatcgtc gccgggtgca
352801 accgtgacgg ccggcacacc accaccgagg tcggcctaag catcgtcgac acctcggcgg
352861 gccgggtgtt ggtgagtccg tcgcgggcat tcgacggcga gtgggtctcc accttcagcc
352921 ctgggacacc gtttgcgatc gccgtcgcga tccaaacact gaccgcgtgc ttgccagacg
352981 ggcaatggtt cccgggacag cgggtgtcgc gggacttctc cacccaatcc tcgtaatcag
353041 aaaccagaaa gtgagcacga tgtcccagga acggtcccgc tgatgtccgg caccgtcatg
353101 cagatcgtcc gcgtcgccat tcttgcggac agcaggttga ccgagatggc cctgcccgcg
353161 gagttgccac tgcgcgaaat cctgcccgcg gtacaacgct tggtggttcc ctcggcgcaa
353221 aacggcgatg gtggccaagc cgactccggc gctgccgtgc aactgagttt ggcgcccgtc
353281 ggcgggcagc cgtttagctt ggatgccagc ctggacaccg tcggtgtcgt cgacggtgat
353341 ctgttggtgt tgcagccggt gcccgccggt ccggccgcgc cgggcatcgt cgaagacatc
353401 gccgacgccg cgatgatctt ttcgacgtcg cggttaaagc cctggggcat agcgcatatc
353461 caacgaggag cgctggccgc ggtgattgcc gtggctctgc tggctaccgg tttgacggtg
353521 acctatcggg ttgccaccgg tgtgctggcc gggctgctgg cggtggccgg gatcgcggtg
353581 gctagcgcgc tggccggatt gttgatcacc atccgttcgc cacgttcggg tatcgcgctg
353641 tcgatcgccg cgctggtccc catcggcgcg gccctggcgt tggcggtgcc aggaaagttc
353701 gggccggcgc aggtattgct gggtgcagct ggggtagccg catggtcgct gatcgcgctg
353761 atgattccca gcgccgaacg ggaacgcgtc gtcgccttct tcaccgcagc ggcggtggtc
353821 ggggcgtcgg tggcgctggc ggccggtgcg caattgctgt ggcagctgcc gttgttgagc
353881 atcggctgcg ggctgattgt ggcggcgctg ttggtcacca tccaggcggc tcagctttcc
353941 gcactgtggg cgcggttccc gttgccggtg atcccggcgc cgggggatcc caccccgtcg
354001 gccccgccgt tgcgcctgct ggaggatttg cctcggcggg tgcgggtcag tgacgcccat
354061 caaagcggct tcatcgccgc ggccgtgctg ctcagcgtgt tggggtcggt ggccatcgcg
354121 gtgcgcccag aggcgctcag cgttgtgggc tggtatctgg tggcggcgac tgcggccgcg
354181 gccaccctgc gcgcgcgggt gtgggattcg gccgcatgca aggcgtggct gctggctcag
354241 ccctatctgg tagccggggt cctgttggtg ttctacaccg cgaccggacg ctatgtcgcc
354301 gcgttcggcg cggtgctggt gctagccgtg ctcatgctgg cctgggttgt ggtggcactg
354361 aacccgggca tcgcttcgcc ggagagctac tcgctgccgc tgcgccggct gctgggtttg
354421 gtcgccgccg ggctggatgt ttcgctgatc cccgtcatgg cctacctggt cggattgttc
354481 gcttgggtgc tcaacagatg atccgtgccg catttgcgtg tctggcggcg accgtggtcg
354541 ttgcggggtg gtggacgccg ccggcgtggg cgatcgggcc gccggtggtg gacgccgccg
354601 cgcaaccgcc cagcggagac ccgggaccgg tggcgccgat ggaacaacgc ggtgcgtgca
354661 gcgtctccgg tgttatcccg ggcaccgatc caggcgtacc gacgcccagc caaacgatgc
354721 tgaatctgcc tgcggcttgg cagttttccc ggggtgaggg ccagctggtg gcgatcatcg
354781 acaccggggt gcagccgggc ccgcgactgc ccaacgtcga tgccggtggt gacttcgtgg
354841 agtcgaccga cgggctgacc gattgtgacg ggcatggcac cctggtcgcc ggaatcgtcg
354901 ccggccagcc cggtaatgac ggcttctctg gtgtggcgcc ggcggcgcgg ctgctgtcca
354961 tcagggcgat gtctacgaag ttctcaccgc gcacatcggg gggcgatccg cagctggcgc
355021 aggccacact tgacgtcgcg gtgctggccg gtgccatcgt tcatgcggcc gaccttggtg
355081 ccaaggtgat caacgtctcc acgatcacct gcctacccgc cgatcggatg gtcgaccagg
355141 ccgcgctggg cgcggcgatc cggtatgcgg cggtggacaa ggacgcggtg atcgtggcgg
355201 ccgcgggaaa caccggagcg agcggatcgg tcagcgcgtc gtgtgattcc aacccgttga
355261 ccgatctgag ccgcccagac gatccgcgga actgggcggg cgtcacctcg gtgtccatcc
355321 cgtcgtggtg gcagccctac gtgttgtcgg tggcgtcgct cacatccgcc gggcagccat
355381 cgaaattcag catgcccggg ccgtgggtgg gcatcgccgc acccggggaa aacattgcgt
355441 cggtgagtaa ctcaggcgac ggcgccctgg ctaacggact gcccgacgcc caccagaaac
355501 tggtggctct cagcggcacc agctacgcgg ccggctatgt ctccggggtg gccgcgctgg
355561 tccgcagccg ctatcccggg ctgaacgcca ccgaggtggt gcgccggctg accgccaccg
355621 cgcaccgcgg cgcccgagag tcctccaaca tcgtcggcgc cggcaacctg gacgcggtgg
355681 cggccctgac ctggcaactg cccgccgaac ccgggggcgg tgccgcaccg gccaagccgg
355741 tcgccgatcc gccggtcccg gcgcccaaag acaccacacc gcgcaacgtc gcattcgccg
355801 gagcagccgc gctgagcgtg ctggtcgggc tcacagccgc gactgtcgcg atagcgcgcc
355861 gacgaaggga gcccaccgaa tgaacccgat cccttcttgg cccggcaggg gccgggtcac
355921 gttggtgctg ctggcggtgg tgcctgtagc gctggcctac ccctggcaat cgacacgcga
355981 ttacgtgctg ctgggcgtgg ccgccgccgt cgtgattggg ctattcggct tctggcgcgg
356041 gctgtatttc accacgatcg cgcgccgcgg gttggcaatc ctgcgccgcc gacgccggat
356101 tgccgagccc gcaacgtgca cgcgcacaac ggtgctggtg tgggttgggc cgccggcatc
356161 ggatacgaac gtgctgccgc tgacgctgat cgcccggtat ttggaccgat acggcatccg
356221 cgccgacacg attcgcatca ccagccgcgt caccgcatcc ggcgactgcc ggacctgggt
356281 cgggttgacg gtggtcgccg acgataacct ggcggcgctg caggcccggt cagcgcgcat
356341 ccccttgcaa gagaccgcgc aggtcgcggc gcgccggctc gccgaccatc tgcgcgaaat
356401 cggttgggag gctggtacgg ccgcacccga cgagatccca gcgttggtgg ctgcggattc
356461 tcgcgagacg tggcgcggaa tgcggcacac cgactcggat tacgttgcgg catatcgggt
356521 cagcgccaat gccgagttgc ccgatacgtt gcccgcgatc cggtcgcgtc cggcgcagga
356581 gacctggatc gcgctggaga tcgcatatgc cgccgggtca tcaacccgct acacggtggc
356641 cgctgcctgc gcattgcgga ccgattggcg gcctggcggc accgcaccgg tggccggcct
356701 gctcccgcaa cacggaaacc acgtgccagc cctgacagcc ttggatccgc gatccacccg
356761 ccgactcgac gggcacaccg atgctcctgc cgacctgctg acccggctgc actggcctac
356821 tcctaccgcc ggcgcccacc gggcaccgct gaccaacgcc gtcagtcgaa catgaggccc
356881 tgcaggaaca cggtcatccg ccgcagatag tccaactggc tcacatgcag caggtggctg
356941 ccggggaacc agtgcagcgc acagcgatcc cactgcttcc acagcgttac cgcgtgctcg
357001 ggtggagcca ttcgatcgcc aaggccggtg atgatcatcc gccggtcctt aggtagcagc
357061 ggccgatagt tcagtgggcc gtggtaggcc agcccggcga tcagctcatc acggctgatg
357121 ttggttagcc gcagtcctag cttgacgagc ttattggccg gaaaccattc gtcgaacagc
357181 ttggcgggca tgacgacggg gcagttgggg atgacagcct caagccgact ttcgaccgaa
357241 gccagcagcg cagacgtgta gccccccagg gatatacccg tcagggcgat acggtcgacg
357301 ccgatgtggc gcaggtagtc cacgatggaa cgaaagtcat acactgcctg cgccatcgcc
357361 tcggcgaagc cgctcaatcc gctagtgaaa tagccgaaac cgctaaacgg cgagaacttt
357421 tcggcccgct ggccgtgaaa cggcaacgtg tacagcaaaa cgtcgtagcc ggaccggtaa
357481 taccaaggca gcgaaaagaa cagcccgttg agcaagtatg acgatcccat gaagccgtgg
357541 atgacgcaca gcgtaggacg cgggccgtcg cggtggcgcc agtgctgcgc gtgcacaatg
357601 ttgttggcgg tcaatgcact ccaccgctgg cgcatcgtgg ggttgatcgc ccggaagccg
357661 ctggcaaatg cgatgttgtc cacggtgccg cgcgcaaccc attcggtgag cgggctggcc
357721 ggccgcgagg tgaccttggg caactccgtc ggcgccggaa aggacttcgc cggatcatgc
357781 gctgccgcaa gttcggcgta gaagttcagg ttgctgcgct cgctgccttc gttgacgtga
357841 cgtagtgcgt tggcgacaac ggccggagtc accgtcgcgg acagcaccga cgcgaccgcg
357901 gtgcgcagcg cgacatcggc gatcgccgaa gactcgacga gtatccgctg gcgggccgac
357961 agcaccgagc gcgagggcag gccctcggcg ccggcatccg cgccggggac gtcgggaatg
358021 gggacgggcg gaccgatcgc gtcggcagtg aacgtccctg acatctcgga catcaatgtc
358081 gatggtaatc gccaatgtgg ctgaccgctg aaggtttcga ctgtatcgtc aatttctcac
358141 tcggtcgagc gcttgtccag gagcacgtac atgtgggatc ccgacgtcta cctggctttt
358201 tcgggtcatc gcaaccgccc gttctacgag ttggtgtcac gggtgggtct cgagcgggcg
358261 cgccgcgtgg tcgacctggg gtgcgggccc ggccacctga cacgctacct ggcacgacga
358321 tggcccggcg cggtgatcga ggctctggac agctcaccgg agatggtcgc tgccgcggcc
358381 gaacgcggga tcgacgccac caccggtgac ctgcgggact ggaaaccaaa gcccgacacc
358441 gatgtggtgg tgagcaacgc tgcgttgcat tgggtgcctg agcattccga cctgttggtc
358501 cggtgggtcg acgagctggc gccgggatca tggatcgctg ttcagatccc cggcaacttc
358561 gagacgccgt cgcacgccgc ggtacgggcg ttggcccgcc gcgagccgta tgcaaagcta
358621 atgcgcgaca taccttttcg tgtgggcgcg gtggtccaat ctccggcgta ttacgcggag
358681 ctgctgatgg acaccggctg caaggtcgac gtgtgggaga ccacgtacct acaccagctg
358741 accggcgagc acccggtgtt ggactggatt accggaagcg cgctggtccc agtgcgtgag
358801 cggctcagcg atgagagctg gcagcagttt cggcaggagc tcattccgct gctgaacgac
358861 gcctacccgc cacgggccga cggtagcacc atctttccct tccggcggct gttcatggtc
358921 gccgaagttg gtggcgcgcg ccgctcaggt gggtagcccc agccgcggcg cctccgctcg
358981 gtaccggtcg acccactcat cagagcgctg gttggcctgc cgttccagca tcggtgcggg
359041 cgccagtttg ggatcctggc cgatggcgtc aagcacactg gccacaatcg cggtcaggtt
359101 gcgccataac accgggtagg cgatatcgat cggatcgatg ccttcctcgg caaaccaagc
359161 gcgccagccg ttttcctgat cgcgcagatt cctgatgatg tgggcgatgg caccggcgtg
359221 gtagacggcc tgcgagtcgc gcttggggtc cggatggccc cgccaaacct gggtttgcac
359281 ggcgcgccag aacgacaccg cttgtgacac cacatcgggc cggtggacgt gcacgaaaac
359341 cggttcgttg ccaatgacgt cgcggattgc cgcgcgcaag ccatccccgg agcgatccgg
359401 caattgtgct gcgcgttgct gcagcagcgc agtctgattc cacatcaact tgccgcccca
359461 gacgccgttg ggcgtgcgac cggaggtgcg gacgtgctca cgccaggcaa ccggcgtcgc
359521 ggtgtccggt gtaccggggt ccagcggatc gagcaattgc aggatcgtgt catcgtcgac
359581 cccagcgaac cactcccggg gctggggggc catcccggtg ctaggcaggt attggaagaa
359641 ctcctgtggt tccccggcac agcccgtcgc gcgcagcgat tccaccagca gcgtgctgcc
359701 gctgcgttgg gtggcgagca ccagatacgg tctcacagcg cgggacatcc gatgagccta
359761 gctgcagtgt tcgtcgatgc cgcggtcggc ggcgatcgct gaccggcccg ttggcgtctt
359821 gcggtggatc cgcagatacg tttcggtgta gcgctcggcg atgcgggaac cggcgaagtc
359881 cgacggaatg acgtcggccg tgcgctgtcg ccaatcatgc agtcgcacgg ccagatcggc
359941 cgcgatcgcg gccacgccct gggtgctgtc gtcgccggct aacaggttat tggtctcggt
360001 gggatcggcg cgtagatcgt agagttcccg ctgcgggcgg ggcgccttga ccaacggtgc
360061 gacggccatg ccggccgggc tttcctggat atcccacggt aggtccagca gcggccgggg
360121 cgcgtaattc tcgatgtagc tgtattcctt ggtgcggatt gcccgaatcg gatcgaacga
360181 gtcgtgatag gtcttggcgg tgtatacgtg gtcacgcacc gcagcgtttt cagtgtccgg
360241 cgcgaggagg gccggtgcgt gtgacacacc ctcgacatcg gcgggtacct cgagtctcag
360301 caggtccaat agcgtcggaa ccagatcgac gccgctgaaa agctcgtcat agacgcgagg
360361 cgccatcgcc cggcgagtgg gcgggcggat gatcagcgcg ataccggttc cggcgtcata
360421 cagtgtggac ttcgcccgcg gaaatgccgg accgtgatcg gtgacgaaca ccacccaggt
360481 gctggcgtct aggccggtat cggccagtgt gtcaagtagc cggccaaccg cctcgtcggc
360541 tgtggcgata gaaccgtaga actcggcgac gtcttggcgc acctcggggg tatcgggcag
360601 atagtcgggc agctcgacgg ccgcgctgtc ggccggccgg tagcgctcat gcggataggg
360661 ccggtgggtt tcgaagaagc cggcggtcaa caggaaccgt tgtccgtcta acgcgggcac
360721 gcgattatgc agccagtcct gggctttggc gaccacgtat tcgcagtagg agttcgacac
360781 gtcgaattcg tcgaagccca gccgctttgg gtaggacgtc tcatgctgca taccgaaaag
360841 agctgagtac caacccgatt cggatagcaa ttgcggtagg gtttggaccc cggtgcggta
360901 ttcccagccg tgatgggcca ggccgaccaa cccgttgctt tgcgggtagc ggccggtgaa
360961 cagcgagccc cgcgatggtg tgcacagcgg cgcggtggca tgtgccctgg tgaacaggat
361021 gccctcggcg gcaagccggt ccagccgcgg gctgtagacg tccggatggt ggtagacgcc
361081 gagatagcgc cccaggtcgt gccagtgcac gatcagcagg ttctcgcgct gccctgtggc
361141 acgctcactc gtcacctttg tcacctctcc agcgaaccgc acccggcgcc gaagccggac
361201 aatagagcct atacgtcgcg aggcactaga tacgccaccg atgatggcgg taggctcgct
361261 gattgaatcg cggcgacggc gtaggcgtgt tgtgtcttgg cgtccaggag tcacgagtcg
361321 acgggaggtt cccgtgtcct ttgtgatcgc acaaccggag atgatcgcgg cggcggccgg
361381 tgagttggcc agcatcagat cggcgatcaa cgcggccaat gcggcggccg cggcccagac
361441 caccggagtc atgtcggcgg ccgccgacga ggtgtctacg gcggttgccg cgctgttttc
361501 ctcgcatgcc caggcctatc aggccgccag cgcgcaagcg gccgcctttc acgcccaggt
361561 ggtgcggacc ctgaccgtgg acgcgggagc gtatgccagc gccgaggccg ccaacgccgg
361621 gccgaacatg ctggccgcgg tcaacgcccc cgcccaggcg ctgttggggc gcccactgat
361681 cggcaacggt gccaacgggg cgccgggcac cgggcaggcc ggcggcgacg gtgggctgtt
361741 gttcggcaac ggcggcaacg gcgggtccgg cgcacccgga caggccggcg gggccggcgg
361801 ggcggccggg ttcttcggca acggtggcaa cggcggggac ggcggggccg gagcgaacgg
361861 cggcgccggc ggcaccgccg gctggttctt cggcttcggc ggcaacggcg gggccggcgg
361921 gatcggtgtt gccggcatca acggcggtct cggcggcgcc ggcggcgacg gcggcaacgc
361981 cgggttcttc ggcaacggcg gcaacggcgg catgggcggg gccggggcgg ccggcgtgaa
362041 cgccgtcaat cccggcctgg ccaccccggt caccccggcg gccaacggcg gcaacggcct
362101 caacctcgtc ggcgttcccg gcaccgccgg tggcggcgcc gatggcgcca acggcagtgc
362161 cattggccag gcgggcggcg ctggcggtga cggcggcaac gcctccacga gtgggggcat
362221 cgggatcgcg caaaccgggg gcgccggcgg cgctggcggt gccggcggcg acggcgcacc
362281 cggtggcaac ggcggcaatg gtggcagcgt cgagcacact ggcgctaccg gctcctctgc
362341 gagcggcggc aatggtgcca ccggcgggaa cggcggggtc ggtgcgcccg gcggtgccgg
362401 cggcaacggc ggccacgtca gcggcggatc ggtcaacaca gccggcgccg gtggcaaagg
362461 cggcaacggc ggcaccggcg gcgccggcgg cccgggcggc cacggcggca gcgttctatc
362521 cggcccggtt ggcgacagtg gcaacggtgg tgccggcggg gacggcgggg ccggggttag
362581 cgccaccgat atcgccggca ccggcgggcg cggcggcaac ggtggtcatg gcgggctgtg
362641 gatcggcaac ggcggcgacg gtggtgcggg cggtgtcggc ggtgtcggcg gggccggtgc
362701 ggctggcgcg atcggcggcc acggcggcga tggcggctcc gtaaataccc ctattggcgg
362761 cagcgaggcc ggtgacggcg gtaagggcgg cctgggcggg gacggcggtg ggcgcgggat
362821 attcggccag tttggggccg gcggggccgg tggtgccgga ggcgtcggcg gcgccggcgg
362881 ggctggcggg accggcggcg gcggcggcaa cggtggggcc attttcaatg ccggtacccc
362941 cggcgccgcc ggcacgggcg gtgacggcgg tgttggcggg accggtgcgg ccggcgggaa
363001 aggcggggcc ggcggtagcg gcggcgtcaa cggcgccacc ggcgccgacg gcgccaaggg
363061 cctcgacggt gccaccggcg gcaaaggcaa caacggcaac cccggctgag tccggattca
363121 ccgagtctgt agataccgtg gtccgcattc gcagttttgt gcgccaacta cagcctcgat
363181 gacacgaccg cggcgaatcc cgtttcccgg gtgcggcgac accgcgtcct acgattagta
363241 ggatctctgg tatgacgaaa gagaagatct ccgtgacggt ggacgcggcc gtcctcgcgg
363301 cgatcgacgc ggacgccagg gcggcgggtt tgaatcggtc ggaaatgatt gagcaggcac
363361 tgcgcaacga gcacctgcgt gtcgctctgc gcgattacac ggctaaaacc gtaccggcgt
363421 tggacatcga tgcctacgca cagcgggtgt accaggcgaa ccgggcggcc ggaagttgat
363481 cgctcccggc gacatcgcgc cgcgccgcga cagtgaacac gagctctacg tcgccgtctt
363541 gtccaacgcg ctccatcggg ccgcggacac cggacgggtg atcacctgcc cattcattcc
363601 gggccgggtc cccgaggatc tcttggcgat ggtggtggcg gtcgagcaac ccaacggcac
363661 gctgctgccg gaactcgtgc agtggcttca tgttgccgcg ctcggtgcgc cactcggcaa
363721 cgcgggcgtg gccgccctac gcgaggctgc ctcggtcgtg acagctctgc tctgttagcc
363781 ctgtcaccgg cgaagatacc tgatatcgcc agatatcatc ggaagatgag tgatgtactg
363841 attcgggaca tccccgacga cgtgttagca agccttgacg cgatcgcggc acgcttgggc
363901 ttgtcgcgga ccgaatacat ccgtcggcgt ttagcccagg atgcgcagac ggctcgcgtc
363961 accgtgacag ccgcggatct tcgacgcctc aggggtgcgg ttgccggtct gggcgatccc
364021 gagcttatgc gtcaggcgtg gaggtgactg accagcgctg gctgatcgac aagtcggcgc
364081 tggtgcggct cacggacagc cctgacatgg aaatctggtc gaaccggatc gaacgcggcc
364141 tggtacacat cacgggcgtg acacgcttgg aagtagggtt ctcggccgaa tgcggggaga
364201 tagcgcgacg ggagtttcgt gaaccgccgc tgtctgcgat gcccgtggaa tacctaaccc
364261 cgagaattga agaccgtgcg ctcgaggtgc agaccttgct tgccgaccgc ggacaccacc
364321 gtggcccgtc gatcccggat ctgctcatcg ccgcgacagc cgaactgtcg ggcttgacgg
364381 tactgcacgt cgacaaggac tttgacgcca tcgccgcgct taccggtcag aaaacagaac
364441 ggctcacgca tcgcccgcct tccgcttaag gagcccgacc aacccttgtg attggcgtgg
364501 gggggcgcta acgtaactgt ctgtaacgtt cgatacagaa ctggcgccgg ggtgcggccg
364561 cgactctacg agccgagaca agccggcgca aggatggcgc accagtgggc gttcccgcca
364621 agaaaaaaca gcagcagggg gagaggtcac gagaatcgat tctcgacgcg accgaacgcc
364681 tgatggcgac caagggctac gcggcgacct cgatcagcga catccgcgac gcgtgcgggc
364741 tagcacccag ctctatttac tggcacttcg gctccaaaga gggcgtgctg gccgccatga
364801 tggagcgcgg cgcgcagcgc ttctttgccg cgatacccac ctgggatgag gcccatgggc
364861 ccgtcgagca gcgatccgag cgccagctga ccgagctggt gagcctgcag tcgcagcatc
364921 cggacttcct gcgcctgttc tacctgctgt cgatggaacg aagtcaggat ccggcggttg
364981 ccgcggtggt gcgccgggtc cgcaacaccg cgatcgcccg atttcgtgac agcatcacgc
365041 acctgctgcc atcggacatc ccgccgggca aagccgatct cgtcgtcgcg gagctgaccg
365101 cgttcgcggt tgcgctgtcg gacggcgtct atttcgccgg ccaccttgaa ccggacacga
365161 ccgacgtcga gcgcatgtac cggcggctgc ggcaagcgct cgaggccctg attcccgtcc
365221 tcctggagga gacatgaaca ccggaaccgc cgtcatcacc ggggccagct ccggcctcgg
365281 gttgcagtgc gcccgcgccc tgctacgtcg cgacgcatcg tggcatgtgg tgttggcggt
365341 gcgcgacccg gcgcgcggcc gtgcggccat ggaggaattg ggggagccaa accggtgttc
365401 ggttctcgag gtggacctcg cgtcggtgcg gtccgtgcgc agtttcgtgg aaaccgtgcg
365461 gaccacgccg ctgccgccga ttcgtgccct ggtgtgcaat gccggcctgc aggtggtgtc
365521 gggcatcgcg ttcaccgacg acggtgtcga gatgacgttc ggggtaaacc acttgggtca
365581 ctttgcttta gtgaccggga ttctcgactg gttggcccgt ccggcgcgca tcgttgtcgt
365641 cagcagcggc acgcacgacc cgagcaagca caccggaatg cccgaccctc ggtatacctg
365701 cgccgccgac ctcgcgcacc cgcccaccga tcagaacacg ccggccgaag gccgccgtcg
365761 atacaccacg tccaagctgt gcaacgtgct cttcacctac gagctcgacc gccgcctcga
365821 tcacggagaa cagggcgtga tggtcaacgc gttcgacccc ggcctaatgc cgggctccgg
365881 cttggcccgc gactatccgc cgatcctgcg actggcgtac cgtctcctgt cgccgatgct
365941 gcgcgtcctt cccttcgttc acagcacccg ggtctccggc gaacacctgg cggcgctggc
366001 ggtcgatccg cggttcgcgg gcgtgacggg ccaatatttc gcgggcgcca aggcgatccg
366061 gtcttccgcc gagtcctacg atcgggcaaa ggcgctcgac ctctgggaga ccagtgaacg
366121 gctgctggcc caggtgacat agctgcgcgt tatcccctaa agaaacccgc caggttggtg
366181 ccaaagttac cgatgccgga aaggaacccc ggcgtcgcga gatccagcgc gctggcgttc
366241 aaccagcccg agatggtgtt gcccacgttg gcgacacccg atcccagcgc gccggtattg
366301 aggtagcccg acaggccggc accggagttc acgaatcccg atacgcttcc ggcgccgctg
366361 ttgaagaagc ccgacgacgg gccgccagtg aggttgaagt agccgggggt caccggaatg
366421 cccaacagcg gcaggccgat caggccctga tagtcgccac tcaccaagaa gccgttgctg
366481 tagctgccgg taatgaacgc accggtgtcc acatcgcccg tgttcgccac gcccgtgttg
366541 tagtcaccgg tgttgaggta gcccgtgttg ccactgcccg ggttgaagcc gccggtgttg
366601 aagctgcccg ggttgaagct gccggtgttg aggtccccgg ggttgaacac gcccgtgttg
366661 gtgctgcccg cgttgccgat gccggtgttg aagccgcccg agttcgcgag accgaagttg
366721 ccggtgccgg tgttaaagat gccgacgttg ccggtgcccg agttgaagaa cccgatgttt
366781 ccgctgccgg agttgaacag cccgatgttg ttgctgcccg agttgaggct gccgatcccg
366841 atctggccgt tgccggtgag cccgacgccg atgttgttgt taccggtatt cgcgaagccg
366901 atgttgtagc tgccggtgtt ggcaaagccc aggttgtcgc tgccgaagtt cgcgaagccg
366961 atgttgtagc tgccggcgtt gccaaagccc aggttgtcgt cgcccagatt tgccaacccg
367021 atgttgtagc tgcccaggtt cgccaagccg atatcgaaga tcccggtgtt ggcgatgccg
367081 atgttgttac cgccgatgtt gaccccgccg aagttgaggt cgccgaggtt gccgatgccc
367141 aggttggagt cgccggtatt aacgaagccg atgttgacgc tgcccaggtt cccgatgccc
367201 gcgttgaggc cgccctggtt tgcgacgccg aagttcagcg tcaggttgcc ggtgttgtcg
367261 aggaacaggc cggccaggtt ggcgccgatg tttgcgatgc ccgagccgaa ggcgggcgtc
367321 gcgaggtcca gcgtgctcgt gttgtagacg cccgagatgg tgttgcccag gttcgccaga
367381 cccgactgca gcgcgccgaa attcagtagg cccgaattgc ccaagccgcc ggcgttaaag
367441 aagcccgaat tgccagcgcc gaagttcccg gagcccgaca tgttgccggc gccgaagttc
367501 ccgaagcccg atacatggcc ggcgccggtg tggaagaaac ccgacgacgg gccggtggtc
367561 gagttgccga aacccggggt accaccgatg ctgatgccga tggggatcgg gccgaagccg
367621 ccggtgccaa ccatgctgat ggtttgctga atgggcgaat cgatggcgat gacttgattg
367681 acatcgatcg tgatggggcc gatcatctcg ttgacaagca ccgccgcagg accaagcaag
367741 actcgtatct ggaaaccggg aatggtgaaa ctgtttggcg tggtggcgac gacggtgccg
367801 gtgatgggta tgtcgattgg aacactcaag tcgtagcggt aggggatttc gggaatggtg
367861 atcgttgtgg aaaggccaat caacccctgg tagtcacctc gccagaagaa cccgttgctg
367921 taattgccgg agatgaacgc gccggtgttg acgttgcccg tgttggccac acccgtgttg
367981 tagtcacccg cgttgaagta gcccgtgttg tagtcaccgg agttgaagct gccggtgttg
368041 tgatcgccga ggttgaagct gccggtattg gtgctgccag tgttgaagct gccggtgttg
368101 atgctgccgg tgttgatgct gccggtgttg ccgacgccgg tgttgacgtt gcccgggttg
368161 aacaggcccg tgttggtgct gcccgtgttc ccgaggccgg tgttgaagct gcccgagttt
368221 gcgatgccga agtttgcggt gccggtgttt ccgatgccca cgttgccggt gcccgagttg
368281 aagaatccta cgtttccgtc accggagttg aacaagccga tgttgtggct gcccgagttg
368341 aagctgccga acccgatctg accggtgccg gtgagcccga tgccgatatt gccgctaccg
368401 gtgttggcga agccgatatt ggcactgccg gtgttagcaa tgccgatatg gtagttgccc
368461 gagttggcga agccgacgct gtagttgccc aggtttgcca agccaatgtt gtggttgccc
368521 acgtttgcga aaccgacatt gaagattccg gtgttcccga tcccgaagtt agagcccccg
368581 aggtttgcca agccgacatt gaggttgccg aggccggcca agtcgaggat cgtcgtgccg
368641 gcgccgccct gcagcaggcc ggcgatgttt gcgaggccgg agccgaaggc cggcgtcccg
368701 aggtccagcg ggctcgtgtt gtagataccc gagatggtgt tgcccacatt cgccacaccc
368761 gatcccaacg cgccgacgtt gagcaagccc gagactcctg aggctgccga cgcaaggttc
368821 cacaggcccg atgtgttgcc gccgacgttg ccgaacccgg atgcggtgcc ggcgccggtg
368881 ttgaagaagc ctgacgacgg gctggtggtc gagtttccga tgcccggcgc tgccggaatg
368941 tcgatgatcg ggatggtgat ggggccgagg ccggcggtgg cgctgatgtt gatcgcggtc
369001 gtgggtccgc ccacggcgat cgcgaacgtg ggaacgctga gcacgaagct cgggacaatg
369061 atgggaccga tgtccggctc ggtatggatg tgaaagctaa acgcgaagga ttcgaagccg
369121 atgatgggga tagtgaaatt gtccaccacg aggtcggtga aactgccggt gatcggtatg
369181 tcgattggga tattgacgtc caagtgcgcc ggaatctccg gaatagtcag cgcgtaggag
369241 taaccgatca ggccctggta gtcgccccgc cacaagatgc cgttgctgta gttgccggag
369301 atgaaagcgc cggtgctgac gtcgcccgta ttcgcgatgc cggtgttgta gttcccggtg
369361 ttgaagtggc cggtgttggt gttacccgcg ttgaagccgc cggtgttgaa gctgccggta
369421 ttgaaattgc cggtgttgaa gttaccgggg ttgaagccgc cggtgttgcc gtcgcccgag
369481 ttgaacaagc ccgtgctggt gctgcccgag ttgccgatgc cgaagtttcc ggtgccggtg
369541 ttgccgatgc cgaagttccc ggtgcccgag ttaaagaagc cgatgtttcc gtcgcccgag
369601 ttgaacaagc cgatgtttcc gctgcccgag ttcagagcgc cgatcccgat ttggccggta
369661 ccggtgagcc cgatgccgat attgttgctg ccggtgttgg caaagccgat attgttgctg
369721 ccggtgttgg caacgccgat gttgtagctg cctaggttgg caaagcccag gttgtcgtcg
369781 ccgaagtttc cgaagccgat gttgtagttg cccagattcg ccacgccgac gtcaaagatc
369841 ccggtgttgc cgaagccggc gttattgctg cccaggtttg ccagcccaag gttcagagtc
369901 atcgtgccca taccgtcgcg catgagaccg gaggcaaagg ccggcgtcac gaggtccaac
369961 gcgctcgcgt tgtagaaacc cgagacggtg tgacccacgt tagtcacacc cgaccccagc
370021 gcaccgacat tgagataacc cgaaatccct gaggcgccgg cgaccacgtt caaaaagccc
370081 gacgcgctgc ccgctccgga gttgaagaag cccgacgacg gactagtggt cgagttgccg
370141 aagcccgatg tcgcgggaat gtcgatgatc gggatggtga tggagccgat accggcgctg
370201 gcggtgatac cgatcgaggt ggtgggtccg cccacggtga tcgccgccgt gggcaaggtg
370261 atattgatgg tcgggatgat gatgggggtg aagtcgatat tattttcggc agctacgatg
370321 ctgaagccct ggagggtgac gaccccggcg tcgatgttga tgggtatatg tatcgggatg
370381 tcgacgccaa aggttagggc gatttcggga atcgctagcg ccgcgtgcaa gccaatgagg
370441 ccctgataat ttccactcca caagaacccg ttgctgtagc tgccggagat gaaggcgccg
370501 gtgtcaacat cgccggtgtt tccgagtccc gtgttgtagc tgcctgggtt gaaatccccg
370561 gtgttggaat cgcccggatt gaagctgccg gtgttgaagc tgccggtgtt gccgataccg
370621 gtattgacgt cgccggagtt gaagaagccg gtgttggtgc tgccggtgtt tccaagcccg
370681 aagtttgcgg tgccggtgtt gccgatgcca acgtttccgt tgcccgagtt gaaaaagccg
370741 atgtttccgc tgcccgagtt gaacaagccg atgtttccgc tgccagaatt cagggagccg
370801 aacccgatct ggccgtcgcc cgtgagccca atgccgatat tgttgctgcc ggtgttcgcg
370861 aacccgatat tgttgctgcc ggtgttggcg aagcccaggt tgtcgttgcc caagtttccg
370921 aagccgacgt tgtagctgcc gaggtttccg aagcccaggt tgtcatcgcc gaagtttccg
370981 aagccgatgt tgtaactgcc cagatttgcc aaaccgatgt cgaatattcc ggtgtttgcg
371041 ccgccgatgt tgttgccacc gatattggcg ctgccgaagt tggcgctgcc gaggtttgca
371101 aagccgatgt tgtagtcgcc gaggtttgca atgccgacgt tgagggtgcc gtggtttgcc
371161 aagcccaggt tgaggaccat ggtgcccgtg ctgtcgcgca gcaggccggc gatactggtg
371221 ctgatgttgg ccaggcctga attgaaggcc ggcgtcgcga ggtccgacgt gctggtgttg
371281 tagaaccccg agacggtggt gcccacgttc gccagacctg atcccagggc gccgacgttg
371341 aggagccccg acgcccccga ggtcgcggag gccaggttcc aaaagcccga attggcgccg
371401 ccgaagttgc cgaagcccga ggcgccgccg gcgccggtat tgaagaaacc tgacgacggg
371461 ttggtggtcg agtttccgaa acctggcgcc gccgggatac tgatgagcgg gatcctaatg
371521 gcgccaccgc cagttatggt gatcgcggta ttcggccctc ctatggcgac tgtcgtcgtg
371581 gggccgacaa ccgtgatgtt cggaatggta atggggccaa agtgggctcg ctggcccgct
371641 attgacgaaa ggacgatatc gccggtgggc ggaatcgtga cgcccataag ggtgatgttg
371701 ccggccgagg cggtgatcgg gatatcgatg ggaatattca cgccgaggct tatggggaga
371761 ggcatatcga tcaccaggtt gaggccgacc aggccctggt aatcgccgct taagaacaac
371821 ccgttgctgt agtttccggt gatgaaagcc ccggtgtcaa cgtcgccggt gttggcgatg
371881 ccggtgttgt agttgccaat gttgaggtag ccggtgttgg tattgcccgg attgaagcca
371941 ccggtgttga agctgccggt gttgaagcta ccggtgttga agctgcccgg gttgaaggcg
372001 cccgtgttga cgtcgccgga gttgaatagg ccggtattgg tgttgccggt gtttccgatg
372061 ccagtgttga agctgcccga gtttgcgatg ccgaagttgc cgctgccgga attgaagaat
372121 ccgatgttgt tgctgcccga gttgaacagg ccgatgtttc cgctgcccga gttgaagctg
372181 ccgaacccga tctgtccgtt gcccgtgagc ccgatgccga cattgttgct gcccgtgttc
372241 ccaaagccga cattgttgct gccggtgttc gcaaagccga tgttgccgcc gcccgcgtta
372301 gcgaaaccca gattgtcgtt gccgacgttg ccgaagccga tgttgtagct gccgaagttg
372361 ccgaagccca ggttgtcgtc gccaaggttt ccgaagccga tgttgtagct gcccaggttc
372421 gccaggccga catcgaagat tccggtgttc ccgatgccga cgttgttgtg gccgatggtg
372481 gcgccgccga agttaaagcc gccgagactt gcgaagccca cgttgaggtt gccgtggttg
372541 gccaagccca agttaatagc cgcagtaccc gcgccgtcgc gcagcaggcc ggcaatattg
372601 gttccgatat ttgccaaccc ggagttaacg gcgggcgtcg agaggtccga cgtgcccacg
372661 ttgtagatac ccgagatggt gttgcccaca ttcgccacac ccgatcccag cgcgccgacg
372721 ttgaggaagc ccgacattcc cgacgttgtg gagaccaggt tcataaagcc cgacgcggcg
372781 cccccgaagt tgccgaagcc cgaggcgctg ccagcgccgc tattgaagaa gcccgacgac
372841 agtccgccgg tcgagttgcc gaagcctgga gtcgctggaa tatggataat cgggatgttg
372901 atggcgtcga cgaccacagt ggcgccgata ttgatcgcgg tagtgggtcc acccaccatg
372961 accacaggtg tgggaccggt tatccgtatc actgggacgg tgaaggggtc gatatcgacg
373021 ggtccgaaaa aaataacagt gacggctgtg ttcggtggaa gatcgagccc gctgtatacg
373081 atgtccgtga agctggcggt gatcggtatg tgaatcggga tattcacgtc gacgctcaca
373141 atcgggattt cgggaatgtc gacgccgatg gcgaggtcga tcagaccctg gttgtcgccc
373201 cgccacagaa ggccgttgct gtggttgccg gagatgaaag cgccggtgtt gatattgccg
373261 gtgttcgcca tgccggtgtt gtaagtcgcc ggtgttgaag tagccggtgt tgtagttacc
373321 tgcattgaag ccaccggtgt tgacgctgcc ggtgttgacg ctgccggtgt tatagctgcc
373381 cgggttcaag ctacccgtgt tgaggtctcc ggagttgaac aagcccgtgt tggtgctgcc
373441 cgcgttcccg atgccgaagt ttccggcgcc cgagtttccg atgccccagt ttccggtgcc
373501 cgcgtttcct atcccgaagt ttccgctgcc cgagttgaac aatccgatgt ttccgtcacc
373561 cgagttgaac aagccgatat tgtggctgcc cgagttcagg ctgccgaacc cgatctggcc
373621 gctgccggtg agcccgatcc cgatattgtt gctgccgata ttcgcaaaac cgatattgtt
373681 gtcacccgtg ttcgcgaagc caagattatt gctgccggtg ttcgcaaagc cgatgttgta
373741 gctgcccgcg tgggcgaagc ccaggttgtc gccgcctaga ttgccgaagc caatattgta
373801 gtcgcccagg tttgccaagc ccacattgaa gattccggcg tttgcaccgc cgacattgtt
373861 gccgccgacg tttgccaacc cgaagttaag ggtcatggtg cccacgctgt ggtgcagcag
373921 gccggagtta aaggctggcg tcgccagatt cgacgtgctc gtgttgtaga gacccgagat
373981 ggtgttgcca acgttagcta cacccgatcc cagcgcgccg acgttcccga agcccgaaag
374041 tcccgaggtt gccgaggcca ggttccaaaa gcccgaagcg ccgccgccga agttgccgaa
374101 gcccgaggcg gtgccggcgc cagcgttgaa gaagcccgac gacgggctgg tggtcgagtt
374161 cccgaagccc ggggccgccg gaatcttgat gagcgggatg ctgacgcccc ccaccatgcc
374221 ggtgaggttg ccgtcgatcg tggtggttgg tccgcccacg gtgatcgtca ccgtgggaag
374281 ggtgagcgtg gattgcggga gctcgaccgg gccgtagtaa acaacgaagg gaacaatgga
374341 tgtgaagggc aaacgcatgc ccggaatcgt catcacgctt ccgggcatga ccatcacctg
374401 atgtatcggc atgctgaata gctgcgcgtt tatcggaatg gcgggaatct cgagggcgat
374461 atcggcaccg atcaggcctt ggtagtcgcc ccgccacaag acgccgttgc tgtagttgcc
374521 ggcgatgaag gcgccggtgt tgacgttgcc ggtgttggcc actccagtgt tgtagtcgcc
374581 ggtgttgaag tagccggtgt tgtagttacc tgcgttgaag ctgccggtgt tgtagttgcc
374641 ggtgttgaag ttcccggtgt tgtagctgcc cgggttgaag ccgccggtgt tgacgtcgcc
374701 ggtgttgaac cagccggtgt tggtgctgcc cgtgttgccg aggccgaagt ttccggtgcc
374761 gctgtttccg atgccgaaat tgccggtgcc cgagttgaac aacccgacgt ttccgctgcc
374821 ggagttgaac aggccgatgt tgtggctgcc cgagttgaag ctgccgaacc cgatctgtcc
374881 gttgccggtg agcccgatgc cgacattgtt gctgcccgta ttcccaaagc cgacattgtt
374941 gctgccggtg ttcgcaaagc cgatgttgtg gccgcccagg ttggccaaac ccaggttgtc
375001 gctgcccagg tttgcaaagc cgaggttgta gctgcccaaa ttgccgaagc cgacgttgaa
375061 cacgccgacg tttccgttgc ccacgttgtt ggcgccgacg tttgccaagc cgagattgaa
375121 gcccgccgcg ctcggggggc cggcagcggc tgccgcggcg ctggtcagcc gctccgatag
375181 gcccgccagc ttcttcagct gctgggtgaa cggcatcaac gcggagacgg ccgccgacgc
375241 tccagcgtga tagccaacca tcgcggccac atcctgggcc cacatccgct cataggcggc
375301 ctcggtggcc gcgatcgccg gagcgttgaa tcccagcaga ttcgagctca ccagcgacac
375361 cagcacggcg cggttggccg cgacgatcgc cggatgcacc gtcgctgccc gcgccgcctc
375421 gaacgtggcc acggctaccc gtgcctgagc ggcggcctgc tcagcctggg ccgttgccga
375481 aatcaaccag cccaggtagg gggctaccgc gcgcgccatc gcaaccgccg cggggccgcg
375541 ccacgccgca tccgccaggc ccgaggtcac cgacccaaac cacgacgccg ccaccgccag
375601 ttcgtcggct agtccgtccc aggccgccgc ggccgccaac atcggccccg atccggcccc
375661 gagatacatc cgtaacgaat tgacctcggg cgccgacacc acgaaatcca tccgtcatac
375721 ccgttcgtca gctggccgtc ggaggtacgt tcaggctaat caatcgtcta ctactcgact
375781 agcccgtgaa cgggtgaaaa atgctaggac attcacgtat tggcccgagt ggggctggtc
375841 gagtatcagg ggaagcttta tggggcaaag tcaagtttgt ggttcgtcgt atcggggcga
375901 tccaaccgag cacatgttta gtgcaccaga acgacgggcc gtgtatcggg tgatcgccga
375961 acgccgagac atgcgccggt tcgtgcccgg cggtgtggtg tccgaggatg tgctggcgcg
376021 gctgttgcac gccgcacacg ccgcgcccag cgtcggtctg atgcagccat ggcgctttat
376081 ccgcatcacc gacgagacac tcaagcgacg catccacgcg ctcgtcgacg acgaacgcct
376141 actcaccgcc gaagccctgg gagcacggga agaagaattc ctggcgctga aggtcgaggg
376201 cattctcgac tgcgccgagc tgctggtggt ggcgctgtgc gaccgcagag ggtcctacat
376261 cttcggccgg cgcaccctgc cccagatgga tctggcgtcg gtgtcgtgcg ccatccaaaa
376321 cctgtggctg gcagcgcggt ccgaaggcct gggcatggga tgggtgtcgc tgttcgaccc
376381 acaacgttta gcggccctgc tggcgatgcc cgccgacgcc gaaccggtgg ccatcttgtg
376441 cctggggccg gtgcccgagt ttccggaccg gcccgcgctg gaactggatg gctgggccta
376501 cgcgcggcca ctcgcggaat tcgtctccga aaaccgatgg agttatccgt cggcgctggc
376561 cacagatcac catcacggcg aataggtcac gccgaccgcg aggttgacgt attcggccgg
376621 cacgtcaaag gccagcgatc gccgcggcaa gcggctcaac acatcttcac cgatagtggc
376681 cttgaagtgc agcgcgagct ggccgctgaa cttcgggtcg acatcggcga catcgagatc
376741 gagttgcaga cccgtcggcg agatttcggc ggttgcggca ccggcctgcg gcccgtccca
376801 gcgcgcgtcg acgacccggc cggctagctt cggcaccatc gacagggttc ccagcacccg
376861 ctgttcggtg aacgccagcg cacccacgta gctggcgatg ctgtgcgatg cccgcagccc
376921 cgggataacg ccggtgaacc gcctggtgac ggccacgtat tcggcaaggt agatgagtcc
376981 ctcagcctca acctgacagc gtaggtcagc aggcagcctg ccgagaccaa accacttgcg
377041 aacaatgaca gccatgaggc cagtatggag tcgttttgtc ggtgccgcac cgatgctggt
377101 aggagttaga gcatgactcg cccgcaagcg cttctcgctg tttcgctcgc ttttgtcgca
377161 accgcggtgt atgccgtcat gtgggtgggg cactcccagg attggggttg gctgcatagt
377221 ttcgattggt cgttgttgaa cgcagcgcac gacatcggga taaagaaccc tgcgtgggtg
377281 cgcttctggg atggtgtatc cctgatcttg ggcccagtcg tgctgcggcc gctgggtttg
377341 ctggccgcga tggtcgcact ggcgaagcgc aagatacgga tagcgttgtt gctgttggcc
377401 tgtttaccgc tcaacgcgat catgacgatc gcggccaaat ccgtggccca ccgcccgcga
377461 ccggcgactg cgctggtatc tgcccattcg acttcgtttc cgtcagggca tgcgttggag
377521 gcgaccgcaa gcgtactcgc gctgctaacc gtcctgttgc ccatgctgca cagcaggttt
377581 actcggcaca tcgccatcac ggtgggcgcg ctgtgcgtgt tgacggtcgg tgttgccagg
377641 gtggcgttga acgtgcatca tccgaccgac gttgttgccg gctgggcgct ggggtacctg
377701 tatttcctcg tgtgcctgtg cgtatttcga ccgccgtcga tattcggtgc ccaacgcgcg
377761 tctcatgctt tgtcgccgcc agtggaggtg tcgagacaac ccgaaccgga agtcgacacg
377821 gcccgctaaa gccatggtgc gctgtgcatt tcgctttgtc accgcacagt gacccagccg
377881 gattctaacc ttgacttgac cacacgaggt gattgtctga cgattgagcg atgagccgac
377941 tcctagcttt gctgtgcgct gcggtatgca cgggctgcgt tgctgtggtt ctcgcgccag
378001 tgagcctggc cgtcgtcaac ccgtggttcg cgaactcggt cggcaatgcc actcaggtgg
378061 tttcggtggt gggaaccggc ggttcgacgg ccaagatgga tgtctaccaa cgcaccgccg
378121 ccggctggca gccgctcaag accggtatca ccacccatat cggttcggcg ggcatggcgc
378181 cggaagccaa gagcggatat ccggccactc cgatgggggt ttacagcctg gactccgctt
378241 ttggcaccgc gccgaatccc ggtggcgggt tgccgtatac ccaagtcgga cccaatcact
378301 ggtggagtgg cgacgacaat agccccacct ttaactccat gcaggtctgt cagaagtccc
378361 agtgcccgtt cagcacggcc gacagcgaga acctgcaaat cccgcagtac aagcattcgg
378421 tcgtgatggg cgtcaacaag gccaaggtcc caggcaaagg ctccgcgttc ttctttcaca
378481 ccaccgacgg cgggcccacc gcgggttgtg tggcgatcga cgatgccacg ctggtgcaga
378541 tcatccgttg gctgcggcct ggtgcggtga tcgcgatcgc caagtaaccc cggacctcga
378601 ttgtgaactg tgcgacgggt tttcggcgtg ttgcgtcgtg agattcacgt tcggcgtcaa
378661 tcggccagcg cgcggcccgg cctgatgttg aagttaaggc ccgccaacga catggtcgcc
378721 tcgtaggttc ggtcgtagcc ggtggcgctg atccgccagc cgtcggtggt tcgtcggtac
378781 tggtcgtggt agaacgcggc gccgatgagc atgaaattga actcggcgac gatgacccgg
378841 tcttgcaggt accagatgcc ggttgcggta tcgccggtca cggtgatttc cggatgggtg
378901 acccggtgtt cggtgatgac acccgggccg agtgcctggc gcaggtagtc gaccaggtcg
378961 gcgcggttgg tgaagtgcag ctccgtaccg accgatgacc cgtaatcgcc ggtgacatcc
379021 tcggccaggg tgtcggtgaa gtcgtcccaa tgcttggtgt ccaatgcccg cagataccgg
379081 tatttgagct gtttgatcgc tgcaatgtcg gctggatcac ccggagtcac cacgccattg
379141 cagcacaccg gctcacgggt agctttgggg tatgagccaa tcccggtacg cggggttgtc
379201 ccgcagcgag ctggcagttc tgttacccga gctgttgttg atcggccagc tgatcgaccg
379261 atcgggcatg gcctggtgta tacaggcatt cggccgccag gagatgctgc agatcgccat
379321 cgaggagtgg gcgggcgcca gcccgatcta caccaagcgc atgcaaaagg cgctgaactt
379381 cgagggcgac gacgtgccca ccatcttcaa ggggctacag ctcgacatcg gcgcgccgcc
379441 gcaattcatg gacttccgtt tcaccctgca cgaccgctgg cacggcgagt ttcacctcga
379501 ccactgcggt gcgctgctcg acgtggagcc gatgggcgac gactacgtcg tcggcatgtg
379561 ccacaccatc gaagatccga cgttcgacgc caccgcgatc gcgaccaacc cgcgcgcgca
379621 ggtgcgcccc atccaccggc cgccccgcaa gccggccgac cggcatccgc actgtgcgtg
379681 gaccgtcatc atcgacgagt cctatcccga ggctgagggt attccggcgc tggacgcggt
379741 ccgtgaaacc aaagctgcca cctgggaatt agacaacgtc gatgcgtctg acgacgggct
379801 ggtggactat tcgggtccgc tggtgtccga cctggacttc ggggcgttct cgcattccgc
379861 actggtgcgg atggccgatg aggtctgcct gcaaatgcac ctgctgaatc tgtcgttcgc
379921 cattgccgtg cggaaacggg ccaaagccga tgctcaactg gccatttcgg tgaacacccg
379981 ccagttgatc ggagtggccg ggctgggcgc agaacgcatt caccgtgcga tggctttacc
380041 cggcggaatc gaaggcgcgt taggtgtgct ggagctacac ccgctgctca acccggccgg
380101 ttacgtgctg gccgaaacgt cgccggaccg tctggtggtg cacaactcgc cagcccacgc
380161 cgacggcgcc tggatttcgt tgtgcacacc ggcatccgtg cagccgttgc aggccatcgc
380221 caccgctgta gacccgcatc tgaaggttcg gatcagcggg acggacaccg actggaccgc
380281 ggaactcatc gaggccgatg ccccagcgag cgaactgccg gaggtgttgg tagccaaggt
380341 cagtcgcgga tcggtcttcc agttcgagcc gaggcgctca ctgccgttga ccgtgaaatg
380401 agctcgatgc gatctgtcaa gtcggtggcg gtaccgcttc ggtgacacca ccgcatcgac
380461 cgcataccaa tgaggttgtc accgaaccgt atacggccca cccgccgcta tggttaacgc
380521 tggccaccga cccctattga cgaaagcctt ccgctatgta cgacccgctg gggttgtcga
380581 tcgggaccac aaacctggtc gcggcgggta acggaggtcc gccggttact cgtcgcgccg
380641 tgctgaccct gtacccgcat tgcgcaccga aaatcggtgt gcctagccag aacccgaact
380701 tgatcgagcc gggcgcccta atgagcggct ttgttgagcg cattggagat gcggtggcgc
380761 tggtgtctcc cgacggatcc gtgcacgatc cagacctctt gctggtcgag gcgctggatg
380821 cgatggtgct gaccgccggt gcggacgcga gttcctcgga gatcgccatt gccgttcccg
380881 cgcattggaa gcccggagct gtacacgcac tgcgtaacgg tttgcggacg cacgtcggct
380941 tcgtccgcag cggcatggcg ccgcgcctgg tttccgatgc gatcgcggcg ttgaccgcgg
381001 tgaactcgga attgggcctg ccccacggca gtgtggtggg gttgcttgat ttcggtggct
381061 ccgcgactta cgtcaccttg gtggagacca agtcggattc caggacgtcg gatttccagc
381121 ccgttagtgc cacggcacgg taccaggact tttccggtag tcagatcgac caggctttgc
381181 tgcttcgggt catcgaccaa ttcgggtacg gcgatgacgt cgatccggcc agtaccgccg
381241 cggtcgggca actcggccaa ctcagggagc agtgccgtgc ggcaaaggaa cgactgtcca
381301 ccgacgttgc cacggaattg ttcgctgagc ttgccgggtg cagctcgagc atcgagatga
381361 ctcgggaaca gctcgaagac ctgatccagg atccattgac cggcttcatc tacgcgttcg
381421 acgacatgct ggcgcgccac aacgcgagct gggcggatct cgcggcggtg gtcaccgtcg
381481 gcggtggtgc caatattccc cttgtgactc aacgtctttc gttccacact cgtcgacctg
381541 tgctgaccgc gtcgcaaccc gggtgcgcgg cggcgatggg tgcgttgctg ctcgccaacc
381601 gtgggggaga gcgcgattcg cgaacgcgga cgtccatcgg cctcgccacg gccgcagccg
381661 ccggcaccag tgtcatcgag ctgccggccg gcgacgtcat ggtcatcgac catgaggcct
381721 tgaccgatcg cgagttggcc tggtcgcaga ccgacttccc aagcgaagct ccggcgcgtt
381781 tcgagggcga ctcgtataac gaaggcggcc cctgctggtc gatgcgtctg aacgcggtcg
381841 agccccccaa aggaccagcg tggcggcgaa tccgggtgtc gcagttgctc atcggggtgt
381901 cggcggtagt ggccatgacc gcgatcgggg gcgtggcatt gacgttgaca gccatcgaga
381961 gacgcccaag cccgctacca accccaattg tgcccggcct ggccccgatg ccgcccggat
382021 ccgtcgtgcc tagctcgcgc gcaccgaccc cgccgccacc gccgtcgacc gttgcgccgc
382081 ttcccagtgc ggcaccggcc ccgacgacgg tcgcgccggc accgccgccg cccacacagg
382141 tggtgacgac cacgacagcg ccacccgtca ccacgacgcc gaggccgtcg ccgaccacca
382201 caacgaccac cgcgccaccg tcgacaacga cgacaaccga gccgccggtg acgaccactt
382261 cgacgattcc aacgattccg acgactacga cgacggtgaa gatgaccacg gagtggttgc
382321 acgtcccgtt tttgcccgtt ccgatcccgg tcccgattcc gcaaaatccg ggtgccggcg
382381 aaccgcagaa cccgttcgga agccttggct ctgggtgagc cgcgttcccc ggagctggcc
382441 ccgtcggtgt caggtccgta gtatcggtat gggttgctga ggaggtcgcg tgggcgacta
382501 tggtccgttt ggattcgatc ccgacgaatt cgatcgggtg atccgggagg ggagcgaggg
382561 actgcgcgac gcgttcgagc ggatcggcag gttcctcagc tcatccggcg cgggaacggg
382621 ctggtcggca atcttcgagg acttgtcccg gcgctcgcgt ccggcgccgg agaccgccgg
382681 cgaggccggt gacggtgtgt gggccatcta tacggtggac gccgacggtg gtgcccgcgt
382741 tgaacaggtg tatgcgaccg agcttgacgc cctgcgcgcg aacaaggaca acaccgaccc
382801 gaaacgcaaa gtccgcttcc tgccatacgg catcgcggtc agcgtcctcg acgatccggt
382861 ggacgaggcc cagtaacgtc agccctgctg gacgctgttg gaaccgccgg cattgctgat
382921 cttcggcgag cccgagtgat acgtgacctc gttgttgaag ccggcggctt cgatggtgtc
382981 gacggagtcg acggtgaccg agttcctcat gccggacacg gtgaggctgg tgcagtggcc
383041 ggtgatcacc accgtgttgg acatgccgct gacgctgaca atgctgtcgt tgcaggcgat
383101 tgtccggttc acgttgacgc cggagacgct caggctggcg ccggccggcg gaagagtggt
383161 ggccggttgc gcagtcgggg ttggaacagc ccgggagaca gacggggtgg gcgagagaac
383221 gacgaagttg ccttgggaaa gccgctgtgc gctgaatgcg gcgatgccac ccaccagaac
383281 cagcacgccg acaacgacga ccgcggccag gatccaccac gccctgttgc cggaggacga
383341 tcgcggcgat gggccgccga acgggccgcc atagctatac ggcggcggtg gcgggccggg
383401 tggataggtg tagccgcccg actgcgagcc gccgagttcg gaggcgcgtg ccacgtcggc
383461 tagcggccgc tccagttccc ggattcgcgc ctccgggtca tcctctgggt tcatgcacag
383521 atgctcccac acgacgatca tgccgcatag gtagttgcgc ccggcggcac cacacgattc
383581 ggcttggcct gctatcgtcc catgcttatg cctgagatgg atcgtcgccg aatgatgatg
383641 atggcggggt tcggcgccct ggctgccgcg cttcccgccc cgacagcctg ggccgacccg
383701 tcccggccgg ccgcgccggc tggtccgaca ccggcgcccg ccgcgccggc tgcggcaacc
383761 ggtgggcttt tgttccacga cgagttcgac gggccggccg gttcggtccc ggacccgtcc
383821 aagtggcagg tgtcgaacca ccggacgccc atcaagaacc cggtgggctt tgaccggccc
383881 cagttttttg ggcagtaccg cgacagtcga cagaacgtgt tcctcgacgg caactccaat
383941 ctcgtgctgc gcgctacccg agagggcaac aggtatttcg gtggcctggt ccacggcctg
384001 tggcggggtg gcatcgggac cacctgggag gcccggatca agttcaactg cctggctccg
384061 ggcatgtggc ccgcctggtg gttgtccaat gacgatcctg gtcgcagcgg cgaaatcgac
384121 ctgatcgagt ggtatggcaa cgggacttgg ccgtcgggaa ccaccgtgca cgccaacccg
384181 gacggcaccg cattcgagac ctgcccgatc ggtgtggacg gtggttggca caactggcgc
384241 gtcacgtgga atccgagcgg catgtacttc tggctggatt acgccgacgg cattgagccc
384301 tacttctcgg ttccggcgac cggaatcgaa gacctcaacg agcccatccg cgagtggccg
384361 ttcaacgacc ccggctacaa ggtgtttccg gtgttgaacc ttgcggttgg cggttctggt
384421 ggcggcgatc ccgcgacggg ttcctatcca caggagatgc tcgtcgactg ggtgcgcgtc
384481 ttttaacgcc tcgcgctctt gcccggggtg ctacccggct tgctcggaga aagcatggag
384541 tttttggtca ccatgaccac ccgcgttccc gatagcatgc ccgcggacgc agtcgagcgg
384601 gtccgtgccc gcgaggctgc ccgctcgcgc gagctcgcgg cacagggaaa gctactccgc
384661 ctgtggcgcc cgccgctgcg gccgggcgaa tggcgcaccc tggggctgtt cgccgccgac
384721 gacaacggcg aactggagca gctgctggcc tcgatgccgc cgcggtcgtg gcgcaccgac
384781 gacgtcacgc cgctgggtgc tcacccgaac gacccggttg gccaggggat aaccatcgcg
384841 ccgggtaagg gtccggagtt tctgatcgcg acgaccatta tggtgccacc gggtaccccg
384901 gctcaggtgg tcgacgacac cgtggcgcgc gaggctcgcc gcgcgcccga gctggccggg
384961 cggggacacc tggtgcggtt gtgggcacta cccgacggac cggacggcca gcgcaccctg
385021 gggctgtggc gggctcgcga ccctggcgag ctgatggcca tcctggaatc gctaccgctt
385081 gctggctgga tgaccatcga gaccacgccg ctgagtccgc atcccgatga tccgatccgc
385141 atgccctgac cgtttccggt gtcgccgggc tcttaggcgc cgtcccactc gccgcgggcg
385201 atgagaacat cacgaagtag gtccgcgcga tcggtgatga tgccgtccac gtccatgtcg
385261 agaagggtgt gcatcacatc gggttcgtcg acggtccagg catgcacttg gcgtcccgca
385321 gcatgaaagc cgcggacccg tgccggcgta atgaccggta caccgccaag ccgtgacggt
385381 agttgcacgc agtcgatgtc gcgcatcatc cgccaggcat atgcccggct gcccagcgga
385441 cgcgcggtca gccacgccag cagcgcgccc gttcctgccg aactagcgac ccgcttggtc
385501 agcaggcgca atgcgcgccg gcgacggcgc tcggaaaacg aaccgatcag cacccggttg
385561 tgcgcgttgc accgctcgat gacgttgacg gtcggctcga tcgccgatgc ggctttaatg
385621 tcgatgttga cccgcatgtc tggcagcgcg gtaagcaggt cttccagggt tgggatcgac
385681 tgccccgcac ccagctgcgc cttgcggaca tcacgccaat ccaaccggtc gaccgcgccg
385741 gataacccca ccccgggcgc cagcctacgg tcatgcagga tcacggctac gccgtcccgg
385801 gtggcgcgaa cgtcggtctc gatgtagcgg aatccgagct tggccgcctc ctggaacgcc
385861 cccatgctgt tcatgggcaa tctgaacgac gtaaatcctc tgtgcgccat ggcaatccgc
385921 cccccatggc gaagaaattc cacggtaggt gcgccaccgt cgctcatcag gtcagtatca
385981 catagcctcg gccgccgggg gcgtccacgc cgggggcagc accgctctgt cggcgacggt
386041 tcctgtgcac cagccgcttt cgcatcgcag tggtaatggg cgctcccata cggcgcggtc
386101 ggcgacgacg gtgcatgggc cggccatcgt tttgggcctt ccccgccttg ccgccgggcc
386161 accgacgttc agcatcacca tcagcgtcga cgtgtcacat cggagccgat gacgggaatc
386221 gaacccgcgt attcagcttg ggaagctgat gttctgccat tgaactacat cggcacggtt
386281 gcctcgaaag gctagcatcc agaatcattc catcaccccc aggccgtaca agatcagaaa
386341 tccggcaaag aacatcacgg ccatccatgg ccgctccggc gtttcgtgcg cctcgacaag
386401 cagttcctcc acgaccagcc agagcagcgc ccccgccgcg aacgccaaca cgagggtcag
386461 gacggtattt cccgcccggc ccagcgccac ggcacctgac acaccgccca ccgcgatcac
386521 taggctcagg gcgcttgtgg tcgccgcggc ccggatccta ggcattccgg agccggccag
386581 gcgcagggcc accgccagac ccaggaacag cacctcgacc gtcagggcga tggtgatgat
386641 gatcgcggtg cgactggaca ccgtcgcgcc cgttgcgacc agcaacccgt cgatgaagag
386701 gtcaaccgcg actacggtga ggaacccgac gggcagttcg cccacgtcgt cgccgtcttg
386761 atgttccccg tggccgtcaa atcggcgcag tgcaacgagt accgcgacgc ctgcactgaa
386821 gcccacaacg atcagccaga gcggacctct gctgcgcagg tctggtagca cttccccggc
386881 cacggcggcc atgacaattc ccgcggcgaa atgttggacg ccgctgacca tcgccgccga
386941 cggcgtgcgc accgacggga ccacgccgcc gagaatcccg gcgagaaccg ggaaggtgac
387001 caacgaggcg gccgttgtga cgttgctgat gccaacctcc cggtttcggt cgaagatctc
387061 ggctcgggca cgcttgaaca ttgtgacggc tagtgacaaa tgcagcgact ttcggggaaa
387121 cgggcattga aataaggaag gaacagcatg tcgaaggtgc tggtcaccgg attcggaccc
387181 tacggcgtga cgccggtaaa tccggcacag ctcaccgccg aagagctgga tggtcgcacc
387241 atcgccggcg caacggtcat ctcgcggatc gtgcccaaca cgttcttcga gtcgatcgcg
387301 gcagctcagc aggccatcgc agagatcgag ccagcattgg tgatcatgct gggcgaatac
387361 ccgggacgca gcatgatcac cgtcgagcga ctcgcgcaaa acgtcaacga ctgcgggcgg
387421 tacggcctcg ccgactgcgc cggcagggtt ttggtcggtg agccaaccga ccccgccggc
387481 ccggtcgcct accacgcgac cgtaccggtt cgcgcgatgg tgctggccat gcgaaaggcc
387541 ggcgtgccag ctgacgtctc ggacgcggcg ggcacgttcg tgtgcaatca cctcatgtac
387601 ggcgtgctgc accacctcgc ccagaagggt ctgcccgtcc gcgccggttg gattcatctg
387661 ccgtgcctgc ccagcgtcgc cgcactggat cacaacctcg gtgttccgag catgtcggtc
387721 cagacggcgg tcgccggggt cacggctggc atcgaggcag ccattcggca gtccgcagat
387781 atccgcgaac cgatcccgtc gcgattgcag atctagggcg cagctgacgg cggtcttcta
387841 gagattagat atttattctt ccgttatctt gtcgtaatct gctcagcgtg ggccgacatg
387901 aattagctag ggaccggcga aagtcgtcag cggtcctggc tgcggtcctc gccccggccg
387961 ccgtgttctt cgccacgggc ggagatgtca gtacgcttgc cgcccgcgcc gatgccaacc
388021 cggttctcgg cgacgacgcg ccctgttgtg tgcagatcgt gccggttgca ccgctggctt
388081 tctcctcaca gatatccggc ggtgaaatcg ggacgggcct tgctgccagc cagttcgctt
388141 cggcatcgag atggcgcatc gtatctcggt atttgccggt aggggtggca cccgagcagg
388201 gtctacaggt caagaccgtc ttgacagccc gcagtatcag tgcggctttc cccgaaattc
388261 gcgaaatcgg cggcgttcgg ccggatgcgc tgagatggca tcccaatggt ttggcgctcg
388321 acgtgatggt tcccaacccc ggcaccgccg agggcatagc gctgggcaac gagatcgtcg
388381 ctttcgtact gaagaacgcg acccgatttg ggatgcaaga tgtgatttgg cgtggcgcct
388441 actacacgcc caacggcgcg cggacaaccg gggccggcca ctacgaccac atccacatca
388501 cgaccgtggg cggcgggtat cccaccggcg aggaactcta catccgctga gccagcgtgc
388561 ggcgacagat acgctcgtcg ggtgctgctc tccgatcgtg atcttcgggc cgagatctcc
388621 tccgggcggt tggggatcga cccgttcgac gacaccctgg tccagccgtc cagcatcgac
388681 gtccggctcg attgcttgtt tcgggtgttc aacaacactc gctacaccca catcgacccg
388741 gccaagcagc aggacgagct gaccagcctg gtgcaaccgg tcgacgggga acccttcgtg
388801 ttgcacccgg gcgaattcgt gctcggctcg acgctggagc ttttcactct gcccgacaac
388861 ctcgccggac ggctggaagg caagtcttcg ttgggccggc tgggcctgct gacgcattcc
388921 accgcgggct tcatcgatcc tggcttcagc ggtcacatca ccctggagct atccaacgtc
388981 gccaacctgc cgatcacttt gtggcccggc atgaaaatcg gtcagctgtg catgttgcgc
389041 ctgaccagcc cgtccgagca tccctacggc agttcccggg cggggtcgaa ataccagggt
389101 cagcgcgggc ccacgccgtc gcgctcctac cagaacttca tcaggtctac ttagcatccg
389161 gcgcggctag gcctgtcgcg ggtagctgtc acctgccgtt tgcctggtgc tcagcgccgc
389221 gatgcggttc gctcatcgca gccacctaca cacagtggtg tgcgatgcag cgtcttcggc
389281 actgggtatc tgggtgccac ccacgccgtc ggtatggcgc aactgggaca cgaggtcgtc
389341 ggggtcgata tcgatcccgg taaggtcgcc aagctcgccg ggggtgacat tccgttctac
389401 gaacccggcc tgcgaaagct gttgactgat aacctggctg ccggccgctt gcggttcacc
389461 accgactacg acatggcggc cgatttcgcc gacgtgcatt tcctgggggt cggcacgccg
389521 caaaagatag gcgaatatgg cgccgacctg cggcatgtcc acgccgtcat cgatgcgctg
389581 gtgccgcgtc tggtcagggc gtcgattctg gtcggcaagt cgacagtccc agtgggcacc
389641 gcagccgaac tgggacatcg ggccggtgca ctggcacccc ggggagtcga cgtggaaatt
389701 gcctggaatc cggaattcct gcgcgagggc ttcgcggtgc acgacaccct caaccccgac
389761 cgtatcgtcc ttggggtaca agatgattcg acgcgcgccg aggtagccgt ccgcgagctg
389821 tacgcgccgc tgctggcagc gggcgtgccg tttctggtga ccgatctgca gaccgcggag
389881 ttggtcaagg tatccgccaa tgcctttctg gcgaccaaga tttcgtttat caatgcgatc
389941 tccgaagtgt gcgaggcggc gggtgccgac gttagccagc tggccgatgc gctcggatac
390001 gacccgcgga tcggacgcca atgcctcaac gcgggcttgg gtttcggcgg cggctgcttg
390061 cccaaggaca tccgcgcttt catggcccgc gccggcgaac tgggagccga ccaggcgttg
390121 acgttcctgc gtgaagtgga cagcatcaac atgcgccggc gcaccaagat ggtggaactg
390181 gccaccaccg catgcggtgg ctcgttgctg ggcgccaata ttgcggtgct cggcgcggcg
390241 ttcaaacccg aatccgatga cgtgcgcgat tcgcccgccc tcaatgtggc gggccagctg
390301 cagctcaacg gcgccacggt ccacgtgtac gatccaaagg ccttggacaa cgcccaccga
390361 ctgttcccta ccttgaacta tgcggtttcg gttgcggagg cctgcgagcg cgcggacgcc
390421 gtgttggtgc ttaccgaatg gcgggagttc atcgatctcg aacccgctga tctagccaac
390481 cgggtgcggg cccgggtgat cgtggacggc cgcaactgcc tcgacgtgac ccgctggcgg
390541 cgggcaggct ggcgggtgtt ccggctggga gtgccgcgat tagggcactg accggcgcag
390601 ccagcgcaag tactctcggt caccgagcag ttccagacga cgccacagca cggggttgtc
390661 ggcggactgg gtgaaatggc agccgatagc ggctagctgt cggctgcggt caacctcgat
390721 catgatgtcg aggtgaccgt gaccgcgccc cccgaaggag gcgctgaact cggcgttgag
390781 ccgatcggcg atcggttggg gcagtgccca ggccaatacg gggatactgg gtgtcgaagc
390841 cgccgcgagc gcagcttcgg ttgcgcgacg gtggtcgggg tggcctgtta cgccgttgtc
390901 gtcgaacacg agtagcaggt ctgctccggc gagggcatcc accacgcgtt gcgtcagctc
390961 gttgagcggg atctgcgcta gaccgttatc cgggtatgcg agtagttgca catgatcgac
391021 acccaggacc tgtgccgcag cggcgagttc ctcccggcgc acctcaccga ggtttcggtc
391081 ggtccggccg agtgtggagg cctcgccgtg ggtgaagcac aatcctcgca gccgcgttcc
391141 ctgcgccgtg aaatcaccca ataccgcccc gagcccgaag gactcgtcgt ccggatgggc
391201 gaacacagca agcacttcgt gtgcgcaggg gagacggttg cagctgttca tcgattcacc
391261 gtccggagga tccgtgcgcg cgggtggaca gccgccgcat attatgtagt tccaatgagc
391321 aatggaatta tattcccaag gatgactgga aatggctgga cagtccgatc gtaaggcggc
391381 gttgttggac caggtagcgc gcgtgggcaa ggcgctggcc aatgggcggc gattgcaaat
391441 cctggacttg ctcgcccaag gtgagcgcgc ggtagaagcg atcgcgacgg cgaccgggat
391501 gaacctgacc acggcatcgg cgaatctgca ggcgctgaag agcggcgggc tggtcgaggc
391561 tcgccgcgag gggacccggc agtactaccg gattgctggg gaagacgtgg caaggctgtt
391621 cgcgctggtg caagtggttg ccgacgagca tctggccgac gtggcggtcg cggccgcaga
391681 cgtgctcggt tcgccggagg atgcgatcac ccgtgcggag ctgctgcggc ggcgcgaagc
391741 cggcgaggtc accctggtcg acgtgcgacc gcacgaggaa taccaggccg gccatatccc
391801 gggcgccatc aatatcccga tagccgaact ggccgaccgg ctcgccgaac taactggcga
391861 ccgcgacatt gtcgcctact gtcgtggtgc ctactgcgtc atggcccccg atgccgtccg
391921 catcgcgcgc gacgcggggc gggaggtgaa acgcctcgac gacggaatgc tcgaatggcg
391981 attggccgga ctgccggtcg acgagggtgc accggtcggg catggggatt gatcgcccgt
392041 ggggccgaag ggaagtctac gtttggtgaa gcggcagcca gaactgctcg ttgcccagca
392101 tgaacactgg caggacacct accgagcgca tccggtgctg tacggaaccc gcccgtcaga
392161 gccgggggta tatgccgccg aggtgttcaa tgccgacggc gtgcagcggg tgctggagtt
392221 ggcggccggt catgggcgtg acaccctgta tttcgctggc tagggcttca cggtggtggc
392281 caccgatttc agcgacgttg ccgtcgcgca acttcgccga agtgcccaag cgcgcggggt
392341 ctccgcgcgg gtgcaaccga ttgtgcacga tctgcgccag cctctgcccg tcaaaaccgg
392401 ttccattgac ggcgcctttg cacacatggc gttgtgtatg gcgttgtcca ccagcgaaat
392461 tcatgcagtc gttgccgagg tcggccgggt gttgaggccg ggtggaaagt tcatctacac
392521 cgttcggcat accggcgatg cgcactacgg cgccgggcag gcccacggtg acgacatctt
392581 cgagtgcgca gggttcgcag tgcacttctt ccgccgtgag ctggtagcgc gcctggctac
392641 cggttgggta ctcgaggagg tacacgattt cgaggaaggt gagctgcccc ggcggctatg
392701 gcgggtcact gtcaccaagc ccgcctagcc ggcgctgtgg gatcagccgc aggtgtgcac
392761 cgtgtttggg gacggtggtg atgttgcgca ccaacggagt ctcgcctttg gacgggccgg
392821 cggcggtgat ggtgaagcgg cggaaaatct cttgcaggat gaccgctccc tcggtgaggg
392881 cgaacccgaa gccgaggcat cggcgcacac cgccgccgaa tggcagccag gtgttgggtg
392941 ccacgctgcc gtcaaggaac cggctaggac gaaactctgt gggtttgggg tgcgatacct
393001 cgctggcgtg ggccaacagg atcgacgtgt tgaccaccgt ccccgctggc agtcgccaac
393061 caccgatctc tgccggcgcg gtgaccttgc gagcggtaga agcgatgacg gtgtgtcggc
393121 gcattccttc cttgaggacg gcctccaaga atccgtcgtc accgccgacg gcagcccaga
393181 ctacttggct ttggatttcc ggagcatggg caagttccca caacgtccag gacagggcgg
393241 cggcggttgt ctcatgaccg gccagcagca acgtgatgag ctggtcgcga agctcggcat
393301 cggtcagcgg cttagtaggc gtgtccttgg tttgcaaaag tctggatagc acgtcggttc
393361 gggcggtgag atcggaatcg atacggcggg aggcgatctc gcggtagagg atctcgtcta
393421 tcttggtttg gttatggaag aagcgcttcc agggattcat ccgcttgagc gacgggtacg
393481 gaacgcccgc gagaatcgcg ggatggatgt ttatgatctg ttgcagccga ctagtcaact
393541 cggccttgac ttttgggtca gtgaccccga aaacgacccg caggatgatg tcgagggtga
393601 gcgcattcat gtggtcaaga ctgttgatcg ttgcgtgggg ccgccagcgc gtgatgtgtt
393661 cacgcgcaac ggaggcgatc atgtcgcggt atccgcgcag cgcggcgcgg gtgaacgcgg
393721 gcatgagcag cgatcgcatc cgcgcgtgtt cggcttcgtc ggtcatcaat accgagtgct
393781 cgcccatgac aaaaccaagg atgtggttgc cttcgcccgc gtgcagcgac ctcgggtcgg
393841 ccgcgaagat ctctttgatg tgttcggggc gggtatagac cacgaggttg tcggcatatg
393901 ggggcacccg caaggagaac acgtcgccgt acttgcgatg catcgctggc aggaaccatt
393961 cccgaaacct caggtacagc acgctctgca ggtagcgggg tagccgcggc ccgggtggca
394021 ggcccgtcgt caacgtgctt gccatggcgg ctcccttctg ataatcaaat gtttgatgta
394081 aacgaatgct tatcacgata ggatgcagct gtgcaacagc aacgcacaaa ccgcgacaaa
394141 ctgctcgacg gcgctctggc ttgtttacga gaacgcggct acggcaacac cagctcgcgc
394201 gacatcgctc gtgcggcagg ggtgaacatc gcgtcgatca actaccactt cggtagcaag
394261 gacgcgctgc tcgacgatgc gctcggccgg tgcttttcga cgtggaacca gcgtgtccag
394321 gaggcattcg atcactcccg cgccgccggt ccggccgggc agatcctggc ggtactcgaa
394381 gccaccgtcg attcgttcga gcagatccgc cccgccgtgt atgcgtgtgt ggagtcatac
394441 gctccggcgt tgcgctcaga ggccttgcgg gagcgcctgg ccgccggata tgccgacgtt
394501 cggcagcatt cggtcgatct ggctggcgct gcgcttgccg gtaccgacat agcaccgccg
394561 gagaacctgt cgaccatcgt ctcggtgttg atggcggtca tcgatggcct catgatccag
394621 tggatcgccg atccgtccgc caccccgcga tcgaccgagg taatccgagc gcttgccagc
394681 atcggcgcgg tcgtcacgtc gcagttgcgg tgaaccacac ggtcgccgga tggtctgcac
394741 tgcgcttgat gccgacgtcg atgaagccgg cagcgccaag ccacgcggcg gtgtcgaggg
394801 tggggggcac gcgatagatc gcgggatcga aacgggccgc cagtggttgg tcatcggata
394861 tcgatgtaag gacgagtcga cccccgggcc gcagggctcg agcgatgtcg caaaggctgg
394921 cgcggggatc gggccagaag taaaagttgt gcacgccgag caccttgtca aggctgtggt
394981 cggcaaccgg cagggttact ccatcgccgt gataaagcga gatcaggccg gctgcaatgg
395041 ctttcgcgtt gtgatgggcc gcgattgcga tcatggtcgt cgacacctcg acgccgctca
395101 cttgcgcgcc ggcggcggcg agcagcccaa gggttcggcc ggggccaaag ccgatctcgc
395161 aaacccgctc gcccgggccg ggcgcgagca gctcgacggc gatgcgattg acgtcggcgg
395221 tctcggctcg ccagatccgt cccagtaggc ggccgaacgc gcctgttggc cgggcagcct
395281 gactggatag gtaccgtcgg gccggatgtg tgaggcgcat ggggacgacc tttcggttgc
395341 aagcggttag tccgaagaag ctgtggtggc ccgaacgaca aactcggcga gggtcgcagc
395401 gatcgcatcg tcatcgatca cgccaggttg cacgatcgac caaggctccg gtgacgggtc
395461 gaagtgaaga tgcaccgccc acaacgcgca caactcgacg atggtccggg ccaccatcgg
395521 tgccggcccg ggcaggatca gaaggccggc gcgctcgcgg tgcactaggt atgcctggac
395581 cgcatcgact tgggcgttcc ggccggtgcc gaaccaaacc tcggcgaggt cgggtagctc
395641 gggggcacag cggtcgacca gtttgagcgc gatccggtgc cgggccaggc ggctgtagag
395701 gtcggtgacg ataccggcga gttctgctcg cgcgtctcca gtcgtcgcac ccggcggcaa
395761 agtcgctcgc aacgcgtgcg tgagccgcat gtcggtgacc tcgccagcca gtcgggccga
395821 caccacagct gcgatctcgc ccgcaacggg agcggccacc ggcagttcgg atgccagcgg
395881 aagggcttcc tgagcgtcgc cgtagcgcac cgccgccgcg aacagcgcag ccttgccctg
395941 ggcgtagcca tacagcgtgc ctttggccag ggcgagtgcg tcggccacgt cctgcacctg
396001 ggtgcgctgg taaccgtggg cgatgaacac ccgcgccgac gcggcgacaa tcgcggaaaa
396061 ccggtccgcg ggaatgctgc gggccatggg ccgataatag tttgactgac tcggtcagtc
396121 accccaagac cttgcgcaag actgcggcgg aatctaatat tccaaagata tatggaactc
396181 gatgcgaagg aatcaggctc atgagcaaga cggttctcat ccttggcgcg ggtgtcggcg
396241 gcctgaccac cgccgacacc ctccgtcaac tgctaccacc tgaggatcga atcatattgg
396301 tggacaggag ctttgacggg acgctgggct tgtcgttgct atgggtgttg cggggctggc
396361 ggcggcctga cgacgtccgc gtccgcccca ccgcggcgtc gctgcccggt gtggaaatgg
396421 ttactgcaac cgtcgcccac attgacatcg cggcccaggt agtgcacacc gacaacagcg
396481 tcatcggcta tgacgcgttg gtgatcgcat taggtgcggc gctgaacacc gacgccgttc
396541 ccggactgtc ggacgcgctc gacgccgacg tcgcgggcca gttctacacc ctggacggcg
396601 cggctgagct gcgtgcgaag gtcgaggcgc tcgagcatgg ccggatcgct gtggctatcg
396661 ccggggtgcc gttcaaatgc ccagccgcac cgttcgaagc ggcgtttctg atcgccgccc
396721 aactcggtga ccgctacgcc accggaaccg tacagatcga cacgttcacg cctgacccgc
396781 tgccgatgcc cgttgcaggt cccgaggtcg gcgaggcttt ggtctcgatg ctcaaggatc
396841 acggtgtcgg cttccatcct cgcaaggccc tagctcgcgt cgatgaggcc gcaaggacga
396901 tgcacttcgg tgacggcacg tccgaaccgt tcgatctgct tgccgtggtc cccccgcacg
396961 tgccctccgc cgcggcgcgg tcagcgggtc tcagcgaatc cgggtggata cccgtggacc
397021 cgcgcaccct gtccactagc gccgacaacg tgtgggccat cggcgatgcg accgtgctga
397081 cgctgccgaa tggcaaaccg ctgcccaagg ctgccgtgtt cgccgaagcc caggccgcag
397141 ttgtcgccca cggcgtcgcc cgccatctcg gttacgacgt agctgagcgc cacttcaccg
397201 gcacgggcgc ctgctacgtc gagaccggtg atcaccaggc agccaagggc gacggcgatt
397261 tcttcgctcc gtcggcgccc tcggtgacgc tgtacccgcc gtcgcgggag tttcacgagg
397321 agaaggtcgc acaagaactg gcctggctga cccgctggaa gacgtgacac gccggtgggc
397381 gcggccccct accacggctc ctaccggcgc ccctgaaaca ccagactgtg gataaccgct
397441 gttgcgcaag cctgctagta gcctcgccaa ggtggactac tcgtcggcat acctggagca
397501 gacccacgcc ttcggcgaac tgatccgcaa cgtcgatcaa tccaccccgg tgccgacctg
397561 cccgggctgg agcctgggtc aactattccg ccacgtcggg cgcggggacc gctgggcggc
397621 gcagattgtc cgcgatcgac tcgaccattt cctcgatcca cgcagcgtcg agggcggtaa
397681 gccaccgccg gaccccgacg acgcgatctc ctggctgtac ggcggggcgc ggctgctggt
397741 cgacgctgtg gaacaaacgg gtgtggaaac gccggtgtgg accttcctcg gaccgcgccc
397801 ggcgggctgg tgggttcggc ggcggctaca cgaggtcgca gtgcaccgcg ccgacgtggc
397861 gatcaccgtc gggggcgaat tcacactgga accgaacgtg gcagccgacg ggatcagcga
397921 attcctggag cgcatagcgg tccaggccgg cagcggcggc acgccattac cgctcgaaga
397981 cgacgacacc ttacatctgc acgccaccga tccggggctt cttgaagccg gcgaatggac
398041 ggttcgtcgc gacgagcgcg gcgtcacctg gtcgcatcgg cacggaaagg gtgccgtggc
398101 actgcgtggc ggcgccaccg agctgctgct ggcgatggtg cgccgactct cggttgccga
398161 caccggcatc gagctgttgg gggatgccgg ggtatggcaa aaatggctgg atcgcacgcc
398221 gctgtagccg ccgcacacgg taactttcag accatgacca catcggagat cgctaccgtg
398281 ctggcctggc acgacgccct caatgccgcc gacattgaga ccctcgtggc gttgtctact
398341 gacgacatcg acatcggtga cgcgcacggg gctgtacagg gccacgatgc gctgcgcggg
398401 tgggccagct cgctcaccac aaccgcagaa cttggccgca tgtacgtgca ccacggagtc
398461 gtggtcgtcg aacaaaagat caccagcggc gaagatccgg gcatcgccag gaccggcgcc
398521 gcggcgttcc gtgtggtcca agaccacgtc gcatcggttt tccggcacga agacttggcg
398581 tcggcgctgg cggccaccga actcaccgag gacgatttgg tcgattgagg tcggcgaacg
398641 gcagttagga gccagttatg cgcgggatca tcttggccgg cggttcgggc acccggctgt
398701 acccgatcac catggggatc agcaagcagc tgctgccggt ctacgacaaa ccgatgatct
398761 actacccgct caccacgctg atgatggctg ggatccgaga cattcagttg atcaccaccc
398821 cgcatgacgc gcccggcttt catcgactcc tgggcgacgg cgcgcacttg ggagtgaaca
398881 tcagctacgc cacccaggat cagcctgacg gtctggcgca ggcgttcgtc attggcgcca
398941 accacatcgg cgccgattcg gtggcattgg tgttggggga caacatcttc tacggcccag
399001 gtctggggac cagcctgaag cgcttccaat ccatcagtgg tggagcaatt ttcgcctatt
399061 gggtagccaa cccgtcggcc tatggtgtcg ttgagttcgg cgccgagggc atggcgctgt
399121 ctctggagga gaagccggtg accccgaagt cgaattacgc ggtgccgggc ctgtatttct
399181 atgacaacga tgtgatcgaa atcgccaggg gtttaaagaa atcagcgcgc ggggagtacg
399241 agatcaccga ggtcaaccag gtctacctca atcagggtag gttggcggtc gaggtgctgg
399301 cccgcgggac agcgtggctg gacaccggga cattcgactc gctgctggac gccgccgatt
399361 tcgtccggac cctggagcgt cggcagggcc tgaaggtcag catccccgaa gaagtggcgt
399421 ggcgcatggg ctggatcgac gacgagcagc tggtgcagcg agcccgtgct ctggtcaagt
399481 ccggatatgg taactacctg ctggagttgt tggagcgcaa ctgatttcgg cgggttattg
399541 tcggtgatta tggaaccccc tggtagcccg tcctggatga gcagcccacc ggaccagcca
399601 ttgccgaaca gcccgccgtt ggcgccgttg gcgatcagcg ggccccaaca gcgcctgggt
399661 cggcgcatcg gcggtggtct cggcgctggc acacgagccc gcacccacgt tcaggttctg
399721 tgcaaactgg ccatggaacg ccgccgcctg attgttgagg gagtgatgcc gccgaccgtg
399781 tgcggaaatc agtgccgcga cggccgccga cacctcgtct tcggccgccg ccagcacgcg
399841 ggtcttgtgg cgcttcggcg ggaagttgct gatccgagat gctggcggct ggtttccttg
399901 tggtggcctg ggccgggtgg tggcgcacag tgggcccggt ggggtcgcgg ccggccgggc
399961 aagaacgctg cgccctggcc gggccatgag cggagccggc aagctcgacg gcgcccggca
400021 tgcgcggtgc aagaacccca tggaccgcac cgagtgccgt gctcgccctc ggcggctacc
400081 gagccggtgt ctccctagtc atccacgtta tccacagcgc cttgggttac cgggcgccgg
400141 tcgggtagcg atggtagtat cgaaagtatg ttcgatcagg tgcgggggcg catgccttca
400201 ccggaggcga tcgctcattt tgatgagcgg tttgaatgcc atgctccgcg gaccacgagg
400261 gtgtcggcgg cgttcatcga tcggatctgc tcggcgactc gggccgaaaa ccgggccgct
400321 gcggcgcagt tggtggcgtt gggggagttg ttcgcctatc ggtggtcgcg ttgcgggggc
400381 cgcgaggagt gggtgatgga caccatggcg gcggtggccg ccgaggtggc ggcggcgttg
400441 cggatcagtc agggtctggc ggccagccgg ttgcggtatg cgcgggcgat gcgtgagcgg
400501 ctgcctaaga cggctgaggt gtttagcgcc ggcgacatcg gctatctgat gtttgccacg
400561 attgtgtatc gcaccgactt gatcgttgac cctgatgttt tggcggcggt ggatgcgcag
400621 ttggccgcca atgtggcgcg ttggccctcg atgaccaagg cccgcctggc tgggcaggtc
400681 gataagatcg tggcgcgtgc cgatgccgat gcggtgcggc ggcgcaagga gtatcaggcc
400741 cagcgccagt tctgggtcgg ggaaagccaa gacggtgtgt gccagatcgg tggcagcctg
400801 ttggccgtcg acgcacacgc cctcgatgcg cggttgagcg cgttggcggg caccgtgtgt
400861 gagcacgatc cgcgcagccg tgagcagcgc cgcgcggacg cgttgggggc gttggcgggc
400921 ggggccgatc ggctgggctg tggctgtggg cgcgctgatt gtgcggccgg gaagcggcct
400981 gcggccccgc cggtggtgat tcacctgatc gccgaggcgg ccacgatcaa tggcacgggc
401041 tcggcgccgg catcgcagat gaacgccgac gggctgatca ccgccgaact ggtggccgag
401101 ctggccaaga cggccacgct ggtgccgctg gttcatcccg gcgatgcgcc gcccgagccg
401161 gggtatgcgc cgtcgaaagc gctcgccgat ttcgttcgct gccgggatct gacgtgtcgc
401221 tggcccggct gtgatgagcc cgccaccaat tgcgacctgg atcatacgat cccgtatgcc
401281 gctggtgggc ccacccatgc gtcgaacctg aaatgttact gccgtaccca tcacctggtg
401341 aaaacgtttt ggggatggcg tgatcaacag ctacccgacg gcaccctgat tttgacctcc
401401 ccgtccgggc atacctatgt cagcaccccg ggcagtgcgc tgctgttccc cagcttgtgc
401461 cacttcagcg gcggcatccc ggcaccggaa gccgacccac cctacgacca ttgcgaccag
401521 cgcacagcga tgatgcccaa acgccggcgc acccgcgccc aagaccgggc ctatcgcatc
401581 gccaccgaac gtcgacaaaa ccacgccgcc cgccagcgcg cccaggtgct cacccagacc
401641 gccgcggcca ccgacaccca cggcccacca ccggatccca acgacgaccc accgccgttt
401701 tgatgtggaa cggcctgtca agtggccgat tagtgcttgt tgcctcgggg ttgtttgggg
401761 tttctggctt tgatccgatg acgggaccct gcggcgctcc ctcgacgccg ccgcgccggc
401821 ttaagggcgc ccggccgcgc tgccaccccc agggcatcac gtgcgtcggc tgctattgcc
401881 ggtaactgac caggaagtta cccagccgct cgatggcggc cgccagatcg cgggaccatg
401941 gcagcgtcac caggcgcaga tgatccggtg cgggccagtt gaacccggtg ccctgggtga
402001 ccaggatctt ctccgacagc agcagatcga gcacgagttg ctcgtcgtcg tcgatgtcgt
402061 agacctcggg gtctagccgg ggaaacgcat acagcgcgcc cgccggtttg acgcacgaca
402121 cccccgggat ctcgttgagc ttggtccagg cgatgtcgcg ctgctcgagc agccggccgc
402181 cgggcagcac caggtcctcg atgctctgat ggccgcccag tgcaacctga atggcatgct
402241 gggccgggac atttgggcac aaccgcatat tggccagcag gccgatgccc tcgatgaagc
402301 tgctggcgtg ctccttgggt ccggtgatcg ccagccagcc ggcccggtat ccggcgacgc
402361 ggtaggcctt cgacagccca ttgaaggtca ggcacaacat atccggggcg atcgatgcca
402421 ggctgatgtg cttggcgtcg tcgtagagga ttttgtcgta gatttcgtcc gccaacagca
402481 gcagttgatg cttgcgggcc agatcgacca tctgggtgag gatttcgcag ctgtacaccg
402541 cgccggttgg gttgttgggg ttgatcacga ccagcgcctt ggtgcgctcg gtgatcttgg
402601 attccaggtc ggcgatatcg ggctgccagc cttgggtctc atcgcacagg tagtggaccg
402661 gagtgccgcc agccagcgag gtcgacgccg tccacagcgg gtagtccggt gatggaatca
402721 gcacctgatc gccgttgtcc agcagggctt gcagcgtcat cgtgatcagc tcggagaccc
402781 cgttacccag gtagacgtcg tccacgtcga atcggggaaa tccgggcacc agctcgtagc
402841 gcgtgaccac cgcacgccgg gccgacagga tgccctgcga gtcggagtac ccctgcgcgt
402901 agggcagcgc ctggatgata tcgcgcatga tcacgtcggg tgcttcgaag ccgaacggcg
402961 ccgggttgcc gatgttgagt ttgaggatgc ggtgaccttc ggcttcgagc cgcgcggcgt
403021 gctggtgcac cgggccgcgg atctcgtaca ggacgtcctg cagcttggcc gactgagcga
403081 aggcgcgctg ccgctgatgg ctggcggtgt gccagggcag ctggtgggtt gtcacgtcca
403141 caatggtgcc atcgttgtcc actggaattt gctgtcaggt gccaaatcgt gatcagcgtt
403201 tgcccggtgg acgggccccg cgcgcaatgc ccagcccttt caccggcgcg gccggtgcag
403261 ccggatcacc gtcggtttgc ggctttggcg gtgcggcggg ctccggttgc ggctttgctt
403321 cgggttgcgg ctgggctgct ggctcggcga gcccaggagc cgggggaggt gtctttttcg
403381 ccccgggccg cttggcgccg gcggcaatac ccagcccttt aacgggcgcg gcgggcgcag
403441 ccggggccgc gggcgttggg gccgctttct tggcgccagg ccgcttggcg ccggcggcca
403501 tgccgaggcc tttcacgggt gctgcgggag cggccggcgc tggcgcctgt ggtgcctcgg
403561 cgggtgcctc cacgggcgtc accggtgcgg cagccttagg agcggctttc ggggcgcgct
403621 cctgagcctg tttggcggcc gtacccttgg ccggcagctg cgccttgtcg tggtctagtg
403681 atccgagtag cacctgggcc acgtcgagca cctcgacgcc gctgcggccg gcttcttcct
403741 gccgatcgtt cacaccgtcg gtgaccatca cccggcagaa tgggcacgcg gtggcgattg
403801 cggtggcatc ggtggccagc gcctcatcga cgcgttcatg gttgatccgc ttgccgatgt
403861 gttcttccat ccacatgcgg gcgccgcctg cgccgcaaca aaagctgcgg tcggcatggc
403921 gcggcatctc ggtcaggctg gcccccgcgg caccgatcag ctcccgtggt gcctcgtagg
403981 ccttgttgtg ccgacccagg tagcacgggt cgtggtaggt gatgtcctga gaaaccggag
404041 tgacagggac cagcctcttg tcgcgcacca accgattgag cagctgggtg tggtgcagca
404101 cggtgtagtt ggcgcccagc tgccgatatt ccttgccgat ggtgttgaag cagtgcgggc
404161 aggtgacaac gatcttgcgg tcgacggtct ccacaccctc gaacaaaccg tccagggtct
404221 cgacggcctg ttgtgccagc tgctggaaga ggaactcgtt gccggagcgg cgcgccgagt
404281 cgccgttgca ggtttcccca gcgcccagca ccaagtattt caccctggcg acggcgagca
404341 gctcggcgac ggccttggtg gtcttcttgg ccttgtcgtc gtaggcgccc gcacaaccca
404401 cccagaacag gtactcgtag ccgtcgaagc tgtcgacgtc ctggccgtac acggggacgt
404461 cgaagtcaac ctcgtcgatc cagttggtgc gatctgaggc gttctgaccc cacgggttgc
404521 ccttggtctc caggttcttg aacagcaccg acagctcgga ggggaactcc gactccatca
404581 tcacctggta gcggcgcata tcgacgatgt gatcgacatg ttcgatatcc accgggcact
404641 gctcgacgca ggcaccacag gtcacacatg accacaagac gtcgggatcg ataacgccac
404701 cctgttcctc ggtgccgacc agcgggcgag tcgcctgctc cggtccatgc ccgggcactc
404761 gaccgaaccc cgattccggc acgtgatgat gctcttggtg accggcctcg ccgcccgcgc
404821 tggcatcctt ttggcccagg atgtagggcg ccttggccat ccaatggtcg cgcaggtcca
404881 tgatgaccag cttgggcgac aacggtttgc cggtgttcca ggccgggcat tgcgactgac
404941 agcgtccgca ctcggtgcag gtagcgaagt cgagcatccc cttccaggtg aagtcttcga
405001 tcttgccgcg gccgaatacg gcatcctcgc tgggattctc gaagtcgatt ggtttgccat
405061 cggcttcgag cggcaacagc gggcccagcc catccggcag ccgtttgaac gtgacgttaa
405121 tgggcgccag gaagatgtgc aggtgcttgg aatgcaaaac gaggatcagg aacgcaagca
405181 tgaccccgat gtgcagcaac agcgctgtgg tttcgatgat ttcgttggcg ggctgcccga
405241 gggggcgaag aatcgcgccg aatagctgcg ataggaaggc cccgttgccg tagggcaggg
405301 tgccgttgtt gaccgctgag ccgcggacca acacgtaggt ccagatgacg ttgaagatca
405361 tcaacaggac gagccacgcg ccgccgttgt gcgatccgta gaaccgggag ctccgaccga
405421 tctcgcgggg gttgcgcagg atacggatga tggcgaaggt cgtgataccg agaaagacgg
405481 cggtggcaaa gaagtcctgc aggaagccca acgcgtccca ccggccgatg accgggatgt
405541 ggaatctctc ctcgaacagc aggccgtaag cctcgatata gacggtgagc aggatgaaga
405601 agccccacat ggtgaaaaag tgcgccaggc ccgggatcga ccatttcaac agtcggcgct
405661 gccctagaac ctcggagatc tgggtccaga tgcgggtgcc gaggttgtcg gttcgcccgc
405721 tggccggctg cccggacatg accagcttgt aaagccacca gactcgccgc agagcgaaca
405781 cccccaccac cgcggtcatg ctcatgccca gtatcagcct gatgagcgtt tgcgtggtca
405841 cggaaggtca ccccaattcg tagcactcaa tggaacccct gcataacctg ctcatcctga
405901 catctgtgcg actttcgccg cgagaaaggc tgtcctaacc taccggtcgt caacgcctct
405961 catctgcggt taagctctcc ggggccagca tggcccgcag catcgacaac atctccgacc
406021 gggagccagc gcccagccgc tggcgtatcc gggcgacgtg gtgctcgacc gtcttcgctg
406081 agatgaacag ccgggcgcca atgtcgcgat agggcatgcc cagtagcagt agctcggcga
406141 cttcgcgttc gcgatcggat agcggcgagc ccgccggtgg ctggcgcggt gccggcgggg
406201 taccggaagc tggttccgtg tcgccggccc cgctgggggg ctcgccgaaa tcgttgccca
406261 gcttaagatc ccgtgccaac tgcagcatgg caccggacac ccgtgcgtcg gatgtttgca
406321 atgcggcctg acctgccagt cgggtcgcat ccgacgtcag gccgacgtgt gacagggacc
406381 gcgccgccgc ggtgacctcg tcggcgtcga cgttttcggc caggacccgc agccaggtgc
406441 gaccggcatc cgacagggcc tgcgcgagcg tgctgtgggc gaccattgca ccgagggcct
406501 gtccgtgcgg tgccaccgat tccggcgaat tggcgaggat tccagcgtgc actccagccc
406561 aatgcagtga gttcgaccac agggcggggt tgcccagcga atccagcagc gtgagcgcct
406621 gatccagggt gtgttgtagc tggtcaacct ggcgcattcg ggcggccgcg acccacagtt
406681 caccaagtgg cagcagggcg aacagatcga gcgaatactc ggccagcgct tccatcgccg
406741 cataccaatg ctgttgcagc gcaccgatat cgccggtgcg acgcgagatc gcggtttgca
406801 gtgccgcggc ccacaacgcg tcgcgccggt gcaggtgcgt gccggcgctg gccgccgcga
406861 cgtccgcgct tgccgacggc aattgcccct cttgcatttt gatccagccg gaaagcagca
406921 ggtgccgacg ctggaacagc gggtcggcgc cggctcgcac ggcacgcccg atcacactgc
406981 gggcgcggac cggatcgccg gcgtgtatcg cggccaaggt aaccagcgct gccgggctgt
407041 ccggaatgac ttggctgagc gattgttcgg tggcaatggc ttggcccagt tttgccatcg
407101 cgaccggata cggctgatcc atggtcagca gcagcccctc ggcgaggttg cgcgcgcaac
407161 gcgctgccat cgtcggtgga ccggcatcct tgagtcgcag ggtggcacgc gccgtcgcca
407221 ggtcgccgtt cgcggcgaac acgatcgtgg cggccgagct caccatcgtg tccgggtgtg
407281 ggcccagcca gccgaacaac tcggctgcgt gtcccgtgtt gccgtcgtgg accgcgacgc
407341 tggccgcaac ccgcaccgcg gcagcgcgtt cggtggcatc cggggagctg agcagatcgt
407401 cggctagtgt tgccgcggcc gtacagtcgc cggtgcgggc cagtgcgtcg gccaggcgga
407461 ccgtcaatcc tttggcgccg gcatggaccg cggcgcggta cagccgtgcg caacggaccg
407521 aagcgtcgcg ggtgtccgcg gcgtaccgcg tgaggatgtc cgccagccgc tcgtcgcgca
407581 gcccgtgttc ggccagtcgc agcgctagct ccgccgacac cggcgagata tcgagttgtg
407641 agcgtaacag cgaggtttcg acctcgtggt ggtgtgcatt gccgacgatc tgagcgatcg
407701 catcatggac tgactgcaga aacgccgcgg tgtgtgacga ctcgatcagt ccgctggcgt
407761 gcgcacgatc gaccaatccg cgggcatccg ttaccgaaat cccaagtgca gcagctacat
407821 cgctgacccc tagctcgtgg gttagcgaca tcatgagcag ggtgtccaga gtgggttcgt
407881 cgaggcggcg cagccgctcg atgagggcca ccttggccgc ttgcgcggga gcctgtgccc
407941 tggcggaaac cgcatgaatg aggaacggca gtcccgcggt gcaatctcgc aggtgctcgg
408001 caaccggaag tggaccgagc gagattcgtg gccggtcccg ttcgagcgcc atcgtcaggg
408061 ctcgtagtgc ccggtggtgc tcgcgggctt ccgcggccgc caccaccgtc agccgtgaat
408121 cggccacgcg ctcggtgagc cggagcaatt cggtatcggt gagcaactgg gcgtcgtcga
408181 tgacgagcgc ggtctccggc ggttcgccgt ctggcggcgg gcatgccagc acggtgagtc
408241 ccgagcggcg cagtgtgtcg cgggcggcag ccagaacggt ggtcttgccc gttccgatgc
408301 ccccggtgat caggaccttg accggtaccg tcggggcatt cgcgagttcc aggagggcac
408361 ggcgtgctgc cggcgggacc tcggtgaggg aatcggtcac cgatgcgtcg tatgcttggc
408421 cacggttctt gcaccccctg tgctgcacgg ctggtcggcg gcggctccct caccatagcc
408481 ccagcccgtc ccgcagcccc gcatttcccc taatgcggcc atcccctaac ggcgccccgg
408541 ggccggcggg ttccgcaccg aacacggacg cggcctcaac cgatagcatc gtgctaacac
408601 gggactaacg ggggtggggc aaggaggcgg gtagtggcaa actcgttgct cgactttgtc
408661 atctcgcttg tgcgcgaccc ggaagcggcc gcacgttacg ccgcgaaccc cgagcggtcg
408721 atcgccgaag ctcaccttac cgacgtgacc agagcggatg tgaacagcct gatcccggtg
408781 gtgtcggatt cgttgtcgat gtccgaaccc atcggagccg ctggcggggc acacgctggc
408841 gatcgtggca acgtttgggc gagcggcgcg gccacggctg cgcttgatgc gttcgcccca
408901 cacgccgatg cgggtgttgt ccaacagcac ggtgcggtcg gcagcgttct caaccagccg
408961 accccacccg gaccgggcgt gacacccacc gatccgcgcc ccttccgagc cggtccacat
409021 gagacgtcgg cgctgctcac gagcgctgaa atacccgaca cgaccagcga ggacggggga
409081 ttgccgacag accatccggc tgtctggaac cacccggtcg ttgacccaca taccgtcgag
409141 cccgatcatc acggctacga catccacgga taagttccgg accggcgtag gggtgcccca
409201 tttcccctaa tcccctaacg cggcggccag gccgatcccg ataggtgttt ggccggcttg
409261 cggatcagac cccgatttcg gggtgaggcg gaatccatag cgtcgatggc acagcgccgg
409321 tcacgccggc gaacagcttc ttcgattgaa gggaaatgaa gatgacctcg cttatcgatt
409381 acatcctgag cctgttccgc agcgaagacg ccgcccggtc gttcgttgcc gctccgggac
409441 gggccatgac cagtgccggg ctgatcgata tcgcgccgca ccaaatctca tcggtggcgg
409501 ccaatgtggt gccgggtctg aatctgggtg ccggcgaccc catgagcgga ttgcggcagg
409561 ccgtcgccgc tcggcatggc tttgcgcagg acgtcgccaa tgtcggcttc gccggtgacg
409621 cgggcgcggg ggtggcaagc gtcatcacga ccgatgtcgg tgcgggcctg gctagcggac
409681 tgggtgctgg gttcctgggt cagggtggcc tggctctcgc cgcgtcaagc ggtggtttcg
409741 gcggtcaggt cggcttggct gcccaggtcg gtctgggttt tactgccgtg attgaggccg
409801 aggtcggcgc tcaggttggt gctgggttag gtattgggac gggtctgggt gctcaggccg
409861 gtatgggctt tggcggcggg gttggcctgg gtctgggtgg tcaggccggc ggtgtgatcg
409921 gtgggagcgc ggccggggct atcggtgccg gcgtcggcgg tcgcctaggc ggcaatggcc
409981 agatcggagt tgccggccag ggtgccgttg gcgctggtgt cggcgctggt gtcggcggcc
410041 aggcgggcat cgctagccag atcggtgtct cagccggtgg tgggctcggc ggcgtcggca
410101 atgtcagcgg cctgaccggg gtcagcagca acgcagtgtt ggcttccaac gcaagcggcc
410161 aggcggggtt gatcgccagt gaaggcgctg ccttgaacgg cgctgctatg cctcatctgt
410221 cgggcccgtt agccggtgtc ggtgtgggtg gtcaggccgg cgccgctggc ggcgccgggt
410281 tgggcttcgg agcggtcggg cacccgactc ctcagccggc ggccctgggc gcggctggcg
410341 tggtggccaa gaccgaggcg gctgctggag tggttggcgg ggtcggcggg gcaaccgcgg
410401 ccggggtcgg cggggcacac ggcgacatcc tgggccacga gggagccgca ctgggcagtg
410461 tcgacacggt caacgccggt gtcacgcccg tcgagcatgg cttggtcctg cccagtggcc
410521 ccctgatcca cggcggtacc ggcggctatg gcggcatgaa cccgccagtg accgatgcgc
410581 cggcaccgca agttccggcg cgggcccagc cgatgaccac ggcggccgag cacacgccgg
410641 cggttaccca accgcagcac acgccggtcg agccgccggt ccacgataag ccgccgagcc
410701 attcggtgtt tgacgtcggt cacgagccgc cggtgacgca cacgccgccg gcgcccatcg
410761 aactgccgtc gtacggcctt ttcggactac ccgggttctg attcgcgagc cgatttcacg
410821 aaccggtggg gacgttcatg gtccccgccg gtttgtgcgc ataccgtgat ctgaggcgta
410881 aacgagcgag aaagtggggc gacacggtga cccagcccga tgacccacgt cgggtcggtg
410941 tgatcgtcga actgatcgat cacactatcg ccatcgccaa actgaacgag cgtggtgatc
411001 tagtacagcg gttgacgcgg gctcgccagc ggatcaccga cccgcaggtc cgtgtggtga
411061 tcgccgggct gctcaaacag ggcaagagtc aattgctcaa ttcgttgctc aacctgcccg
411121 cggcgcgagt aggcgatgac gaggccaccg tggtgatcac cgtcgtaagc tacagcgccc
411181 aaccgtcggc ccggcttgtg ctggccgccg ggcccgacgg gacaaccgca gcggttgaca
411241 ttcccgtcga tgacatcagc accgatgtgc gtcgggctcc gcacgccggt ggccgcgagg
411301 tgttgcgggt cgaggtcggc gcgcccagcc cgctgctgcg gggcgggctg gcgtttatcg
411361 atactccggg tgtgggcggc ctcggacagc cccacctgtc ggcgacgctg gggctgctac
411421 ccgaggccga tgccgtcttg gtggtcagcg acaccagcca ggaattcacc gaacccgaga
411481 tgtggttcgt gcggcaggcc caccagatct gtccggtcgg ggcggtcgtg gccaccaaga
411541 ccgacctgta tccgcgctgg cgggagatcg tcaatgccaa tgcagcacat ctgcagcggg
411601 cccgggttcc gatgccgatc atcgcagtct catcactgtt gcgcagccac gcggtcacgc
411661 ttaacgacaa agagctcaac gaagagtcca actttccggc gatcgtcaag tttctcagcg
411721 agcaggtgct ttcccgcgcg acggagcgag tgcgtgctgg ggtactcggc gaaatacgtt
411781 cggcaacaga gcaattggcg gtgtctctag gttccgaact atcggtggtc aacgacccga
411841 acctccgtga ccgacttgct tcggatttgg agcggcgcaa acgggaagcc cagcaggcgg
411901 tgcaacagac agcgctgtgg cagcaggtgc tgggcgacgg gttcaacgac ctgactgctg
411961 acgtggacca cgacctacga acccgcttcc gcaccgtcac cgaagacgcc gagcgccaga
412021 tcgactcctg tgacccgact gcgcattggg ccgagattgg caacgacgtc gagaatgcga
412081 tcgccacagc ggtcggcgac aacttcgtgt gggcatacca gcgttccgaa gcgttggccg
412141 acgacgtcgc tcgctccttt gccgacgcgg ggttggactc ggtcctgtca gcagagctga
412201 gcccccacgt catgggcacc gacttcggcc ggctcaaagc gctgggccgg atggaatcga
412261 aaccgctgcg ccggggccat aaaatgatta tcggcatgcg gggttcctat ggcggcgtgg
412321 tcatgattgg catgctgtcg tcggtggtcg gacttgggtt gttcaacccg ctatcggtgg
412381 gggccgggtt gatcctcggc cggatggcat ataaagagga caaacaaaac cggttgctgc
412441 gggtgcgcag cgaggccaag gccaatgtgc ggcgcttcgt cgacgacatt tcgttcgtcg
412501 tcagcaaaca atcacgggat cggctcaaga tgatccagcg tctgctgcgc gaccactacc
412561 gcgagatcgc cgaagagatc acccggtcgc tcaccgagtc cctgcaggcg accatcgcgg
412621 cggcgcaggt ggcggaaacc gagcgggaca atcgaattcg ggaacttcag cggcaattgg
412681 gtatcctgag ccaggtcaac gacaaccttg ccggcttgga gccaaccttg acgccccggg
412741 cgagcttggg acgagcgtga gcaccagcga ccgggtccgc gcgattctgc acgcaaccat
412801 ccaggcctac cggggtgcgc cggcctatcg tcagcgtggc gacgtttttt gccagctgga
412861 ccgcatcggt gcgcgcctag ccgaaccgct gcgcatcgcg ttggctggca cactcaaggc
412921 cggaaaatcc actctcgtca acgcccttgt cggcgacgac atcgctccga ccgatgccac
412981 cgaggccacc cggattgtga cctggttccg gcacggtccg acaccgcggg tcaccgccaa
413041 ccatcgcggc ggtcgacgcg ccaacgtgcc gatcacccgt cggggcgggc tgagtttcga
413101 cctgcgcagg atcaacccgg ccgagctgat cgacctggaa gtcgagtggc cagccgagga
413161 actcatcgac gccaccattg ttgacacccc gggaacgtcg tcgttggcat gcgatgcctc
413221 cgagcgcacg ttgcggctgc tggtccccgc cgacggggtg cctcgggtgg atgcggtggt
413281 gttcctgttg cgcaccctga acgccgctga cgtcgcgctg ctcaaacaga tcggtgggct
413341 ggtcggcggg tcggtgggag ccctgggcat catcggggtg gcgtctcgcg cggatgagat
413401 cggcgcgggc cgcatcgacg cgatgctctc ggccaacgac gtggccaagc ggttcacccg
413461 cgaactgaac cagatgggca tttgccaggc ggtggtgccg gtatccggac ttcttgcgct
413521 gaccgcgcgc acactgcgcc agaccgagtt catcgcgctg cgcaagctgg ccggtgccga
413581 gcgcaccgag ctcaataggg ccctgctgag cgtggaccgt tttgtgcgcc gggacagtcc
413641 gctaccggtg gacgcgggca tccgtgcgca attgctcgag cggttcggca tgttcggcat
413701 ccggatgtcg attgccgtgc tggcggccgg cgtgaccgat tcgaccgggc tggccgccga
413761 actgctggag cgcagcgggc tggtggcgct gcgcaatgtg atagaccagc agttcgcgca
413821 gcgctccgac atgcttaagg cgcataccgc cttggtctcc ttgcgccgat tcgtgcagac
413881 gcatccggtg ccggcgaccc cgtacgtcat tgccgacatc gacccgttgc tagccgacac
413941 ccacgccttc gaagaactcc gaatgctaag ccttttgcct tcgcgggcaa cgacattgaa
414001 cgacgacgaa atcgcgtcgc tgcgccgcat catcggcggg tcgggcacca gtgccgccgc
414061 tcggctgggc ctggatcccg cgaattctcg cgaggccccg cgcgccgcgc tggccgcagc
414121 gcaacactgg cgtcgccgtg cggcgcatcc actcaacgat ccgttcacta ccagggcctg
414181 tcgcgcggcg gtgcgcagcg ccgaggcgat ggtggcggag ttctctgctc gccgctgacg
414241 cgtcaggccc tcgggtgtca cagtggtggg cgtgactggt ggcgccaacg caacggtgat
414301 cagccaccgg gtggaacatg ttttcgagcc caaggggcag cgacggcagc tcggggcaca
414361 agggtcataa gggcatgcgc tcagaatgtg tcgaccttct cgatgctgac gaacatgcca
414421 tggcccgtgc ggttgttcgt gaagcgggtg ccatcggtgg tggcgtcgat ggtccagccc
414481 tgcgcctcat aggttcggta gtcgatgctg acggtgggga tggcgcccag attgcccaac
414541 acccactgca cggagccgcc ggcggtgatg tggatgccgt tggcgtgctc accatctcgc
414601 aagggggagt tggtgaacgg tgcctcgcag ccaacgctgt ccctattgat ctggcaacgc
414661 gtcattccgg acttggtttc gatgaagacg taaccgttgg agtcaggcgg gagcggaatg
414721 gcgccggccg gcgcggtcgg gctgaccggt gtcgtcggta gcgtcggggc ggtggtcccc
414781 ggcggcgcgg tagttggcct aggcgtcgga aaagtcggct cggtaggtcc cgaccctggc
414841 gaagcgaccg gcctgccgtc gatggtggtg ttgcagccgg caactagcgc ggtagccgcc
414901 agcagggccg ccataccccg tgcaatgagc gatagccgca cgcgctactc cccggaaatc
414961 tgagatatcg ggagtaggtt acgcgcgagg tcccgcaatt tactgcagtg acgcgcttct
415021 gcaacggccc gcataatcgg agaatggcgt tgttgccgtc gacggtcgtg ggagtcttgc
415081 tggccgcggg tgcgggccgg tggtatggca agccgaaagt gctggttgac gggtggctgg
415141 acaccgcggt cggggcgttg cgcgacggtg gttgtaacga cgttattttg gtgctgggtg
415201 ctgtcgaggt gtcggcaccg gccggtgtca ccgcgattac cgcgccggac tggcagcagg
415261 ggctgagcgc gtcagtgcgt gcgggtctgg cccaggccga ccgcgagcac gccgactacg
415321 ccgtcctgca tgtgatcgac acgcccgatg tcaatgccaa ggtggtggct cgagtccttg
415381 gccgtgcctt ggtatcccgc agcggtctgg cagggcgcgg ccgcatacct gcgcacagtg
415441 cccgacgtcg aggctgttga gtgcggcgac ttggctagtg gtcgcgatgt cgacgtggac
415501 ctcagattgg atccgccgaa tggacgaccg cgacactctt ggtgtggtcg atggcgtggt
415561 gcgcgacggc cgtcacacga ttgcggacca aataccagcc accgatgagg gccggtacac
415621 cgatcaccgt tgcggcgatc atccagggac cgtgttgttc gtcgaagtac atcaggatca
415681 gcacgccggc caggaaagcc agcgtcagat agccgctgaa cggtgaaagc ggcatccgga
415741 atttcggccg ctgcagctgc ccggcgttcg ccatccggtg gagccgcagc tggcaagcca
415801 cgatcgtcgc ccaggccgcg atgactcccg tcgcggcgat gtggagcacg atctcgaagg
415861 cttggctcgg tttgatggcg ttgagaatga tgcccaacag gccgataccg gcggtgagca
415921 ggatcccgcc gtacggcacg ccggtcttcg acattggtgc ggtgaacctc gggccgctgc
415981 cgttgatcgc cattgatcgc aggatccgtc cggtggaata cagtccggcg ttgaggctcg
416041 acagcgcggc ggtgagcacg acgaggttca tcacgctgcc cgccgcgtcg ataccgatct
416101 tggaaaagaa ggtcacgaac gggctgacat gttctttgta ggcggtatag ggcagcagca
416161 gggccagcag gacagtcgac ccgacgtaga agcacgcgat gcgcaacacc acagagttga
416221 tcgcgcgcgg catgatcttt gccggttcgg ctgtttcccc ggccgcgatg cccaccagtt
416281 cgattgcggc gtaggcgaat accacccccg aggtgaccag cactatgggc agcagaccgg
416341 ttggcacgat gcctccatgg ctgctccaca gggagacccc ggtctcctgg ccgtcgatct
416401 tgtagcgccc agcgagaaag accgtaccga cgatcagaaa cgtaaccagc gcgatcacct
416461 tgatcaatga ggcccagaac tccagctcgc cgaagagcct gaccgagatc aggttcatcg
416521 acaacacgac cagcagcgcg atcaacgcca gcgtccactg ggggatgggt tgaaacgccc
416581 gccagtaatg gcaatagtgc gcgatcgcgg tggtatcgac gatccccgtc atcgcccagt
416641 tcaggaagta catccacccg gcgacgaagg ccaccttttc cccgtagaac tcgcgggcgt
416701 aggacacgaa tgaccccgag gacggacggt gcagcaccag ttcgccgagc gcgcgcagga
416761 tcaggaacac gaagatgccg cagatcccat agaccaggaa caaaccgggc cccgccgatg
416821 caaggcggcc gccggcgccg agaaaaaggc cggtaccgat ggcaccaccg agagcgatca
416881 tttgcagttg ccggctatgg aggcctttgt gatagcccgt gtcttcgcgc gtgagccgct
416941 cgtcggtgat gtctagcggt ggcattgagc tccctgggat ggtggcttct tgggacgcgc
417001 gtgagatggg gcacacccaa cggactggct gtcaggctat cccacgcggc tgcgaggtgc
417061 cgcttggcaa ccaatcggaa acaatcgatc ggtcaacggt gctttgttgt cgtgccgacc
417121 gtcgcgggtg gccgcgttga cagtcgatat tgcggtcaca ggctgacgcg cctggccagc
417181 cagacgctcg cgaagtgcgg gtccgtcctg gccgcgaggg tgtcgtagcc gcggtcgtag
417241 tgtgagactc cgacacctga tccgccagcg cagagatgtg agatcaacgg acggaaggcg
417301 acggtgcccg gcgcgcgcga gttgacgctg cgcgtcgagc gcggggctct atttcggcgt
417361 cgatgggcag catcggcagc gtcatcagct cgcgcagcaa ttcgtcgtga tccgcggcgc
417421 tgcgcgctgg gtacccggcc tcgatgggta tcatttttgg ttatcgttct ggttatcatg
417481 aatgttgtga cggcccatcc caagtacccg aatgaccctc ttgcgctggt attgattgaa
417541 ctgcgccatc cgcggaccga gccgccggtg ccatctgcta tctccatcct gaaggaggag
417601 ctggcgcgat ggactcccat actcgaacag gaggaggtgc ggcaggtcaa cctagaaacg
417661 ggcgaacata ccgcacactc acagaagaag ctcgttgccc gtgatcgccg caccgcgatc
417721 acgtttcgac ccgacgccat gaccctcgaa gtcaccgact acccgggctg ggaggagttt
417781 cggtccatcg ttcacgcgat ggtcacagcc cgccaggacg tggccccagt cgatggctgc
417841 atccggatcg gtctgcgcta catcaacgag attcgggcat cgctggcgga gccatccggc
417901 tgggcgtact gggtggcgga aagtctcctc gggcctggga cacagcttgc cgatctcaaa
417961 ctcaccacca ccgcgcaacg gcacgtcatt cagtgcgaag gcccggagcc aggcgactcc
418021 ttgacactga ggtacgccgg tgcgcgcggc gcggtcatcc agtcaacccc gtttctccag
418081 cggttgaaag aacctccggc agaaggagat ttcttcctca tcgatatcga cagcgcgtgg
418141 agcgacccct gcaagggcat cccagcgctc gacgcccacc tggtggacga ggtcgccgaa
418201 aggctccaca cacccatcgg cccactgttc gaatcgctga taacttccga actccgtaca
418261 aaggtgctgc aacaacctgg gcaggagtga ccatgaccat ttcgttctct agctcgaatc
418321 tccgagacga cgccacctct ggcaacggcg attaccgcct cgacaagctg cccgaaacca
418381 ccccatcgac ctcggtgttc gaccgcgccg atgtcaccta ccgccaattc acggaactcc
418441 acgggcaagc ccgcgacaca cggcgggagg cgcacgtggt tgagctggag tccaagaccg
418501 gcgagcgggc tcggtgcgca cccatgcatg cgcttgagca gctcgcggac tacggctttg
418561 cctggcggga catcgcacgc gttgtcggag tgagcgtgcc cgcaatcacc aaatggcgca
418621 agggcgctgg agttaccggc gagaaccggc taaaaatcgc ccgtctactc gccctcatcg
418681 acatgctctc ggaccgattc atcggcgagc ccgcctcctg gctggaaatg ccgatccaag
418741 ccggagtggg aatcacccga atggacctcc tggagcgagg tcgatatgac ctcgtattgg
418801 cgctggctag tacccacact ggggacggta cggtcgaata cgtactgaac gagactgata
418861 aggactggcg agagaccgtt gtagacaacg ctttcgaatc ctacacagcc gaggacggcg
418921 tgatctcgat aagacccaag cggtaaccgt gccagagctg gagacgcccg acgacccaga
418981 gtcgatatac cttgcccgcc tcgaggatgt cggagaacac agaccgacgt tcacgggcga
419041 catctaccga ctcggcgatg gtcgcatggt gatgatcctc cagcacccat gcgcgctgcg
419101 gcacggcgtt gacctccatc cgcgactgct ggtcgctccc gtaagacccg actcgcttcg
419161 ttccaactgg gctagagccc cgttcggcac gatgccgctt ccgaagctca tcgacggtca
419221 ggatcactcg gcggacttca tcaatcttga actcatcgat tcaccaacgc ttccgacctg
419281 tgagcggatc gcggtgctca gccagtcagg cgtcaacttg gtcatgcaac ggtgggtgta
419341 ccacagcacc cggctcgccg tgcccacgca cacctactcc gacagcaccg ttggcccgtt
419401 cgatgaggca gacctgatcg aggagtgggt gacggatcgc gtcgacgatg gggccgaccc
419461 gcaggcggcc gaacacgaat gcgcctcctg gctcgatgaa agaatcagcg gccgcactcg
419521 gcgagcgctg ctcagcgacc gtcagcacgc cagttcaata cggcgagaag cgcgttctca
419581 tcgaaagtcg gtcaagctgg cggactgagc actgctctcc gggcttgacc ggggcctctc
419641 ccagctacgc cccgagcgtg tgccctgccg acacgcggga acaagacccg cacgaccagc
419701 gttagcatgc tcagtaagtt gagtgcatca ggctcagctc tgaattgaca gcacaccgcc
419761 gtcgaggcaa gcttgagcgg ggtgcactca tcatagtgca ggaaagaagc tctacatatt
419821 caggaggatt caccatggct cgtgcggtcg ggatcgacct cgggaccacc aactccgtcg
419881 tctcggttct ggaaggtggc gacccggtcg tcgtcgccaa ctccgagggc tccaggacca
419941 ccccgtcaat tgtcgcgttc gcccgcaacg gtgaggtgct ggtcggccag cccgccaaga
420001 accaggcagt gaccaacgtc gatcgcaccg tgcgctcggt caagcgacac atgggcagcg
420061 actggtccat agagattgac ggcaagaaat acaccgcgcc ggagatcagc gcccgcattc
420121 tgatgaagct gaagcgcgac gccgaggcct acctcggtga ggacattacc gacgcggtta
420181 tcacgacgcc cgcctacttc aatgacgccc agcgtcaggc caccaaggac gccggccaga
420241 tcgccggcct caacgtgctg cggatcgtca acgagccgac cgcggccgcg ctggcctacg
420301 gcctcgacaa gggcgagaag gagcagcgaa tcctggtctt cgacttgggt ggtggcactt
420361 tcgacgtttc cctgctggag atcggcgagg gtgtggttga ggtccgtgcc acttcgggtg
420421 acaaccacct cggcggcgac gactgggacc agcgggtcgt cgattggctg gtggacaagt
420481 tcaagggcac cagcggcatc gatctgacca aggacaagat ggcgatgcag cggctgcggg
420541 aagccgccga gaaggcaaag atcgagctga gttcgagtca gtccacctcg atcaacctgc
420601 cctacatcac cgtcgacgcc gacaagaacc cgttgttctt agacgagcag ctgacccgcg
420661 cggagttcca acggatcact caggacctgc tggaccgcac tcgcaagccg ttccagtcgg
420721 tgatcgctga caccggcatt tcggtgtcgg agatcgatca cgttgtgctc gtgggtggtt
420781 cgacccggat gcccgcggtg accgatctgg tcaaggaact caccggcggc aaggaaccca
420841 acaagggcgt caaccccgat gaggttgtcg cggtgggagc cgctctgcag gccggcgtcc
420901 tcaagggcga ggtgaaagac gttctgctgc ttgatgttac cccgctgagc ctgggtatcg
420961 agaccaaggg cggggtgatg accaggctca tcgagcgcaa caccacgatc cccaccaagc
421021 ggtcggagac tttcaccacc gccgacgaca accaaccgtc ggtgcagatc caggtctatc
421081 agggggagcg tgagatcgcc gcgcacaaca agttgctcgg gtccttcgag ctgaccggca
421141 tcccgccggc gccgcggggg attccgcaga tcgaggtcac tttcgacatc gacgccaacg
421201 gcattgtgca cgtcaccgcc aaggacaagg gcaccggcaa ggagaacacg atccgaatcc
421261 aggaaggctc gggcctgtcc aaggaagaca ttgaccgcat gatcaaggac gccgaagcgc
421321 acgccgagga ggatcgcaag cgtcgcgagg aggccgatgt tcgtaatcaa gccgagacat
421381 tggtctacca gacggagaag ttcgtcaaag aacagcgtga ggccgagggt ggttcgaagg
421441 tacctgaaga cacgctgaac aaggttgatg ccgcggtggc ggaagcgaag gcggcacttg
421501 gcggatcgga tatttcggcc atcaagtcgg cgatggagaa gctgggccag gagtcgcagg
421561 ctctggggca agcgatctac gaagcagctc aggctgcgtc acaggccact ggcgctgccc
421621 accccggcgg cgagccgggc ggtgcccacc ccggctcggc tgatgacgtt gtggacgcgg
421681 aggtggtcga cgacggccgg gaggccaagt gacggacgga aatcaaaagc cggatggcaa
421741 ttcgggcgaa caggtaaccg tcactgacaa gcggcggatc gatcccgaga cgggtgaagt
421801 gcggcacgtc cctcccggcg acatgccggg agggacggct gcggccgatg cggcgcacac
421861 cgaagacaag gtcgccgagc tgaccgccga tctgcaacgc gtgcaggccg acttcgccaa
421921 ctaccgtaag cgggcgttgc gcgatcagca ggcggccgct gaccgagcca aggccagcgt
421981 tgtcagccaa ttgctgggtg tactggacga tctcgagcgg gcgcgcaagc acggcgattt
422041 ggagtcgggt ccactgaagt cggtcgccga caagctagac agcgcgttga ccgggctggg
422101 tctggtggcg ttcggtgccg agggcgagga tttcgacccc gtgctgcacg aagcggtgca
422161 acacgagggc gacggcgggc aggggtccaa gccggtaatc ggcaccgtca tgcggcaggg
422221 ctaccaactg ggtgagcagg tgctgcggca cgccttggtc ggcgtcgtcg acacggtggt
422281 cgtcgacgcg gccgaactgg agtcagtcga cgacggcact gcggtcgcag ataccgccga
422341 aaacgatcaa gctgaccagg gcaatagcgc cgacacctcg ggcgaacagg cagaatcaga
422401 accgtcgggc agttaacaac aaaagaggaa ggcgagaggg ggtgacgcga catggcccaa
422461 agggaatggg tcgaaaaaga cttctaccag gagctgggcg tctcctctga tgccagtcct
422521 gaagagatca aacgtgccta tcggaagttg gcgcgcgacc tgcatccgga cgcgaacccg
422581 ggcaacccgg ccgccggcga acggttcaag gcggtttcgg aggcgcataa cgtgctgtcg
422641 gatccggcca agcgcaagga gtacgacgaa acccgccgcc tgttcgccgg cggcgggttc
422701 ggcggccgtc ggttcgacag cggctttggg ggcgggttcg gcggtttcgg ggtcggtgga
422761 gacggcgccg agttcaacct caacgacttg ttcgacgccg ccagccgaac cggcggtacc
422821 accatcggtg acttgttcgg tggcttgttc ggacgcggtg gcagcgcccg tcccagccgc
422881 ccgcgacgcg gcaacgacct ggagaccgag accgagttgg atttcgtgga ggccgccaag
422941 ggcgtggcga tgccgctgcg attaaccagc ccggcgccgt gcaccaactg ccatggcagc
423001 ggggcccggc caggcaccag cccaaaggtg tgtcccactt gcaacgggtc gggcgtgatc
423061 aaccgcaatc agggcgcgtt cggcttctcc gagccgtgca ccgactgccg aggtagcggc
423121 tcgatcatcg agcacccctg cgaggagtgc aaaggcaccg gcgtgaccac ccgcacccga
423181 accatcaacg tgcggatccc gcccggtgtc gaggatgggc agcgcatccg gctagccggt
423241 cagggcgagg ccgggttgcg cggcgctccc tcgggggatc tctacgtgac ggtgcatgtg
423301 cggcccgaca agatcttcgg ccgcgacggc gacgacctca ccgtcaccgt tccggtcagc
423361 ttcaccgaat tggctttggg ctcgacgctg tcggtgccta ccctggacgg cacggtcggg
423421 gtccgggtgc ccaaaggcac cgctgacggc cgcattctgc gtgtgcgcgg acgcggtgtg
423481 cccaagcgca gtgggggtag cggcgaccta cttgtcaccg tgaaggtggc cgtgccgccc
423541 aatttggcag gcgccgctca ggaagctctg gaagcctatg cggcggcgga gcggtccagt
423601 ggtttcaacc cgcgggccgg atgggcaggt aatcgctgat ggcgaagaac ccaaaggacg
423661 gggaatcccg gacgtttttg atctcggtag ccgccgagct agccggcatg catgcacaga
423721 ccctgcgtac ctacgatcgt cttgggttgg tcagcccgcg gcgcacctcc ggtggcgggc
423781 gccgctattc cctgcatgac gtcgagttgc tgcgccaggt gcagcacctc tcgcaggacg
423841 agggggtcaa cttggccggc atcaagcgca ttattgaact gaccagtcag gtcgaggcgc
423901 tgcagtccag gttgcaagag atggctgagg agttggcggt gttgcgtgcc aaccagcgcc
423961 gcgaggtcgc ggtggtgccg aagagcaccg ccctggtcgt ctggaaaccg cgccggtgag
424021 cgagcgcgcg tagcggggga gcgaacggcg cagttggcac cagccggtga gcgagcgcgc
424081 gtagcggggg agcgaacggc gcagttggca ccagccggtg agcgagcgcg cgtagcgggg
424141 gagttagggt ccgctaccgt tgttgaggat gccggagagt cgggctccgt ggttgccgaa
424201 gccggagata agggcttggg tcgcgaggtc cagcatgctc gtgttgtaga aaccggagac
424261 ggtattgcct aggttcgccc agcccgacag caggttgccg aagttttgga agcccgaatt
424321 cctacgccgc cagcattgaa gaagcccgaa gtctcggtga agacgtttcc caggcccgac
424381 acggcggctg cggcgtcgtt gaggaagccc gatgcgccac cggcgccgga gttgaagaag
424441 cccgacgacg gggttgtggt cgagttgaag aatcccgggc tctgctgcca gccgaagccg
424501 aaggggaacg cgcccacggt gccgctgccg gcgaaatcga gggtttgggt gaaagccgtg
424561 tcgatgggct ggtcggggtt gatcgtgctg gcatcgattt cgtaggggcc gagatgttcg
424621 gtggtgatgg gtatggtgac cgagacatgc tttacacacc ccttgaaagg gatgtagatc
424681 acgcagaccg acacccgcaa cttgatgggt atttcgaatt cgtcaatagt gaacgcgtcc
424741 tgggtgatgg cgttgatgtc gccctcgatg ggtatttcaa tgttggaacc tgtcgtagct
424801 ccacgggatt tcggaaacgg cgctctggta ggcgaaaccg cctaggccct ggtagtcgcc
424861 ccgccagaag aagccgttgc tgtagttgcc cgaattgaag gcgccggtgt tgacatcgcc
424921 ggagttggcg atgccggtgt tggagttgcc cgggttgaag tagccggtgt tgtagttacc
424981 ggggttgaag ccgccggtgt tgtagtcgcc ggggttgaag ctgccggtgt tggtgttccc
425041 ggcgttgaat aggccggtgt tgtagtcacc ggagttgcca atgccggtgt tgaccaggcc
425101 ggtgttgaag aagccggagt tggtgctgcc ggtgttgccg atgccggtgt tgtagtcacc
425161 ggagtttccg atgccccagt tgccggtgcc ggagttgccg aagccgatgt tgccggtgcc
425221 ggagttgaat agcccgatgt tgccggtgcc cgagttccag ccgccgaacc cggtcatggt
425281 gtcgccggtc agcccgatgc cgatgtttcc gtttccggtg ttgccgaagc cgatgttgcc
425341 ggtgccggta ttgccgatgc cgatgtttcc gtttccggtg ttgccgaagc cgatgttgcc
425401 gatggccgcc gtcagccccg gaccgacgtt gccgaacccg atgttggagc tgccgatgtt
425461 ggcgctgccc aggttgaagt cgccgatgtt ggcgctgccc aggttgaagt cgccgatgtt
425521 ggcgctgccc aggttgtaga cgccgatgtt ggcgctgccc aggttgtagt tgccgatgtt
425581 tgcgctaccc agattccaga acccgaggtt ggccaagccc acgctgaagg tcgtctcggt
425641 cgggccgttc tgcaaccacc cagccaggtt ggtgccgatg ttgagcaagc ccgagacatt
425701 tgccggtgct cccaagccgg tgttgtagat gcccgagatg ctgttgccca aattcgccca
425761 gcccgactgc agcgacccat agttttggaa gcccgaattt cccatgctgc tagtggcgaa
425821 gttgtagagg cccgagttgt tgccgaagtt cagcaagccc gatgcgctgc cagcacccca
425881 gttgaggaag cccgacgacg ggccggtggt ggcgttgaag aagccgggcg ctggccgcaa
425941 gtcgatgatc ggaatgctga tcgggccggc gccggcgccg cccacgatgt tgatcacggt
426001 ggagccgtcg ggcttgccga tgttgaggtt gatcgccggc gaggggccga agtcaatttc
426061 gatgggtgtg tccagcgggg ccgacgcgtc cccgccatgc agggtgatcg gaccgaccgg
426121 ggccaagacg gtgccactga ggatgcctat gtcgacgctt ccgctggcgt cgattctggg
426181 gaacgtaatg gcggggatgg agacattggt gatgtcgccg gtgatgggga tgttgaccgg
426241 gatgtcgaca ttgaggaacg cggcaggtcg ctcgatggtg atggtgtagt tggccgccag
426301 caggccctgc cggtcggcgc gccagagcaa gccgttgttc atgctgccgg tgatgaacgc
426361 gccggtgccg tagtctccgg cgtttgccat gccggtgttg tagctaccgg tgttgtagga
426421 gccggtgttg tagtggcccg ggttggcgat gccggtgttg aaggtgccga tgttgaacag
426481 gccggtgttg tggttgcccg ggttggcgat gccggtgttg accaggcccg cgttgagcaa
426541 gccggtgttg tagttgccgc tgtttccgat gccggtgttg ccggtgccgg tgttgccgat
426601 gccgacgttg ccggtgcccg agttgccgat gccgacattg ccggtgcccg agttaaacaa
426661 gccgatgttg aaactgcccg agttggtgcc gccgatgccc acctggctgt cgccggatag
426721 gccgacgccg aagccgccgg tgcccatgtt gccgatgccg acgttgccgg tgcccgagtt
426781 gaacaagccg gtgttgccgg tgccggagtt gaacaagccg gtgttggcgg tgccggagtt
426841 gaagaaaccg gtgttgccgg cgccggagtt cagggagctg aagccggaca agccgtcgcc
426901 ggtcagcccg atgccgacgt tgttgttgcc ggtgttgaac aagccgatgt tgttgttgcc
426961 ggtgttggca atgccctggt tgaagttgcc cgcgttggcc atgccaaagt tgttgtcgcc
427021 caggttgaac aggcccatgt tggcgatgcc ggcgttcagc gggccgaacc cgatctggtt
427081 gtcgccggac aggccgatgc cgatgttgtt gttgccggtg ttgccgaagc cgatgttgta
427141 gttaccggtg ttgccgacac cgatgttgta gttgccggtg ttgccgatac cgatgttgtt
427201 gacagccgcc gttagccccg gaccggtgtt tgcgatcccg acgttaaagt cgccgatgtt
427261 tgcgccgccg atgttcgcgt tgccaatgtt gccgaagccg acgtttgaat tgccgaggtt
427321 tgcactgccg aggtttgcac tgccgaggtt tgcactgccg aggtttgcac tgcccacgtt
427381 gaattggccg aggtttgcca ggcccgcgtt gaaggtcgac ccgttcgggc cgcggagcac
427441 gccggtcagg tcggcgccga cgttggagag tcccgagagg ttagccggcg tcgcgaagtc
427501 cgccgcactg gtgttgtaga agcccgagac ggtgttgccc aagttcgccc agccggattg
427561 cagcgagccg aagttctgca agccagagtt tcctatgccg gcgaaagcgg tgttccagaa
427621 gcccgaattg ttggcgccga cgtttccgaa tccagacgag ctgccggtgc cggagttgaa
427681 gaagcccgat gaggggccgg tggtcgagtt tccgaaaccg ggggccggcg ggatgtccag
427741 tagcgggatg acgaccgggc cggcgccgct ggtgatcgtg atgggtatcg aggatgaacc
427801 gccggggtcg ccgatgttga tatcgatcac cggtaaggtg ccggcgatcc tcggaacgat
427861 gatgggtccg acgctgaagt gggtgacccc gagggcgcgg agggtgatag ccggaatctg
427921 gaagccgttg acggcaaggg taccgaagtc gagatggatg gggatgttga ccggaatgtt
427981 gaggctaaag ttcagtagcg ggatctgggg aacagtgatt gcgtagtgtg cgccccactg
428041 gccttggtga tcgctctgcc agaaggcgcc gttgctgaag ttgcccccga tgaaggcgcc
428101 ggtgttcacg tcgccggtgt tgtagaagcc ggtgttgtag tcgccggtgt tgtagaagcc
428161 ggtattgaag tcgccgtcgt tgaagctgcc ggtgttggtg ctgccggtgt tgtagctgcc
428221 cgtgttggcg atgcccacgt tggcgatgcc ggtgttggtg ctgcccacgt tgtagccacc
428281 ggtgttgtag gtgcccacgt tggcgacgcc catattgccg gtgcctgggt tccacaggcc
428341 ccagttgccg gtgcccgagt tccccaagcc ggtgttgccg acacccgggt tgccgatccc
428401 ggtgtttccg atgcccgagt tgccaatgcc gatgtttccg gtgcccgagt tgaacaaacc
428461 gatgttgttg gtgcccgagt tgaacaggcc ggtgttggcg gtaccggagt tccaggagcc
428521 gaacccctgt tgattgtggc cggacagccc gataccgatg ttgttgttgc cggtgttggc
428581 aaacccgatg ttgttgctgc cgctgttggc gaagcccagg ttgaaatcgc cggcgttgcc
428641 gaatccgaag ttgtagctgc ccaggttgcc taggccgatg ttgtagttac ccaggttcgc
428701 cgggccgata ttgtatgagc cccggtttcc ggagaagacg ttgaagctgc cgatgttgcc
428761 atggccgacg ttcgcgttgc cgaggtttcc gaggccgacg ttggagtcgc cgatattgcc
428821 gtggccgaca ttcccgctgc ctacgttgcc aaacccgagg ttgaggatct gggtgttgtt
428881 gacgaagccg gcgaccgtag caccgacatt ccctccgccg gagagattgg ccggcatcga
428941 aagcccaagc gtgctcgcat tgacaaggcc ggagacagtg ttaccgaagt tgaacccgcc
429001 ggagatcagc tcgccgaagt tctggacgcc cgagattccc gagcttccag aggtgaggtt
429061 gaagaagccg gaactattgc tgcccacgtt gccaacgccc gacacggtac cggtaccggc
429121 gttgaagaat cccgacgacg gggtggtcgt cgagttcccg aatcccgggg ccgccggtat
429181 atcgatgagt ggaatcttga tcggcaatag accgccggtg ccggcgatat cgatcagcgg
429241 gtccggcccg ctacccaggt tgatgccgat attgggaagg acaatcgaga tgttcgggaa
429301 actgaatgca tcgagtgtgg cggcattgaa cggtatgccg atcaagaaga tatcgccggt
429361 gatctccggg aatctgaagc catgaacggt gaacgtgcca agtgtgccgg tgaccgggat
429421 atcgaggaag atcggcacgt gcagtttcac cggaacggcg gtgtcgggca cggtgatcgt
429481 ttggctgatc cccgccaggc cttggtaatc gccccgccac cagaacccgt tgctgtaatt
429541 gccggtgatg aagccgccgg tgttgacatc gcccgagttg gccagtccgg tgttgtagct
429601 gccggtgttc aaataacccg tgttgtagct acccgggttg aagccggccg tgttgaagct
429661 gccggcgttg aagctgccgg tgttgtaatg gccggtgttg aagatgccgg tgttgacgtt
429721 gccggcgttg agcaagccgg tgttgacgtc gccggtgttg aagatgccgg tgttggtgtc
429781 accggtgttg gcgatgcccc agtttccggt gcccgagttg ccgatgccga tgttgccggt
429841 gcccgagttg aacaaaccga tgttgttggt gccagagttg aacaggccgc tgttgccgct
429901 gccggagttc cagccaccgg caaaattgaa gccctgctgg ttgtcgccgg acaggccgat
429961 accgatgttg ttgttgccgg tgttggcaaa cccgatgttg ttgttgccgg tgttggcgaa
430021 gcccaggttg aagtcgccgg cgttgccgaa tccgaagttg tagctgccca ggttgcctag
430081 gccgatgttg tagttaccca ggttcgccgg gccgatgttg tatgagccct ggtttccgcc
430141 gaagacgttg aagctgccga ggttgccgct gccgaggttg aagctgccga tgttcgccaa
430201 gccggcgttg ctgtcgccta cgttggagaa gccgacgttg aattggccga tgtttcccag
430261 gccgaggttg aacatcgaca tcccggtcgc ctggtcgtgg aagaaccccg cgaggttgct
430321 gccgatgttg aacatgcccg agacgttggc cggtgccccg atgccggtgt tgaatacgcc
430381 cgagacggta tcgcccaggt tcgccagtcc cgattgcagc gagccgtagt tgttgaagcc
430441 cgaggtcgcg gagttcgcga cgttctggaa gccggaaatg ttggcgccga tgttggcgat
430501 gcccgatacg gttccggggc cgccgttgaa gaagcccgag gacggatcgg tggtggcgtt
430561 gaaaaagccc gtggtagccg caatgttgac gaacgtgaca tcgaagggac cgacgcttgc
430621 ggtggccggg atcctgatcg cggtcgaacc gccagggtcg ccgatgttga ccgtgatcgc
430681 gggaccggtc ccggtgatgg gcgggagaac ggccttgctg attgcaccgg ccagcagggg
430741 gatccctgcg atgtcgatgg tgaaaccgaa gttgatttgc tcaagcgtta tgccgctgta
430801 gacggtgttg gtgaagctgg cggtgatggg gatgttgacg ggaacttcca cggtgacgtg
430861 tgcgggtatt tcgggaacat ggacccgata gcccgcgctg aataggccct gctggtcgcc
430921 gcgccagaag gcgccgttgc ccatgtcgcc ggtgatgaaa gccccggtgg cgatatcacc
430981 ctggttggca aagcccgtac tgaaattgcc ggtgttgtag aagcccgtgt tgaagtcgcc
431041 caggttggcg atgccggtgt tggtgtcgcc ggtgttgtac cagccggtgt tgtagctgcc
431101 cgcgttggcg acaccggtgt tgacgatgcc ggtgttgaag aagcccgtgt tagtgctgcc
431161 ggtgttgccg atgccggtgt tgccgctgcc ggagttgccg ataccccagt tgccggtgcc
431221 cgagttgccg atgccgacgt tgttggtgcc ggagttgaac aagccgatgt tcgcggtgcc
431281 tgagttccag ccgccagcaa aattgaagcc ctgctggttg tcgccggaca gcccgatgcc
431341 gatgttgttg ttgccggtgt tggcaaatcc gatgttgttg ttgccggtgt tggcaaagcc
431401 ttggttgaaa tcgccggcgt tgccgaagcc gatgttgtag ttacccaggt tcgcgaaacc
431461 gatgttgtag ttacccaggt tcgccggacc gatattgtat gagccctggt ttccggagaa
431521 gacgttgaag ctgccgacgt ttccgctgcc caggttgaag tcgccgagat ttgcgctgcc
431581 gatgttcaac tggcccaggt tggcaaggcc cgcgttgaag atcgtcccgg tcggaccgcg
431641 gaacacgccg gacaggttgg tgccgatgtt gttcaggccc gagacattgg ccggcgtgga
431701 gaggttcacc gtactggtgt tgaaaaagcc cgatacggag ttgcccaggt tcgcccagcc
431761 tgactgcagc gagccgaggt tctggaaacc cgaattccct atcgcgctgc tcaaaccact
431821 gttccagacg cctgaactgc cgccgccgac gttttggaag ccagatgtgc caccggtgcc
431881 cgagttgaag aagccggacg aggggttggt ggtcgaattt ccgatgcccg gcgccggatc
431941 gatcttgagg aaggtaatcg tgcggctctc cagagcaccg acaatgctga tggggacggt
432001 caccgtcggt ccgccgatgg tgagggtgat cgtcggaacg gtcagcgtgg atgcgctgag
432061 attgaccggg ccgaagaaga acaaaccgct cagatagaag gtttggggga aaacggtcga
432121 ggcctcggtg accgtgatca tgttgccgcc gaaggtcatt acgttgtgta cgtcaatgac
432181 catctgctcg tttatgggga tgaatggagt ggtgaccgag agatcgatgg caatctggcc
432241 ctggttatcg cccgccacca agaagccatt gttgaagtcg cccgtgtcga aagcgccggt
432301 attgacgttg ccgggattga agaagccggt gttggtgtca cccgggttat agctgccggt
432361 attggtgtca cccacgttga agttgccggt gttggtgtta ccgacgttga agccgccggt
432421 gttgtagctg cccgtgttgt agaagcccgt gttgaagtcg ccggcgttga ggatgcccgt
432481 gttgtagctg ccagcattga ggatgccggt attgtcggta cccgggttcc cgatacccca
432541 gttcccggtg cccgagtttg cgatgccgac gtttccggtg cccgcgttga agatgccaac
432601 gttattggtg cccgaattga acaggccgct gttgccggtg cccgagttcc agccgctagc
432661 aatattgaag ccctgctggt tgtcgccgga cagcccgatg ccgatgttgt tgttgccggt
432721 gttggcgaac ccgatgttgt tgttgccggt gttggcaaag ccttggttga agtcgcccgc
432781 gttcccgaag ccgacgttgt agtcgccgac gtttccaaaa ccgatgttgt agatcccgag
432841 gtttccggat ccgatgttgt agtttcccag gcttccggaa ccgacattga atactccgat
432901 gtttccactg ccgatattga agctgccgac gttgccgctg cccaagatgt tttggctgcc
432961 gaggttgccg ctgccaagga tgttgaagtc accgacgttt ccgctgccga gaatgttgta
433021 attgccgatg ttggcgttgc cgagaatgtt cacgacgccc cggtttgcca ggccgagatt
433081 gaagaccggt gggccaccga aaaatcccga catgttgctt ccggtgttga agaagcccga
433141 gatcaaggcc ggcgttgtga tggccaccag gctcatgttg aacaaacccg atacggtgtt
433201 gcccgagttg atcacgcccg ataccagcac gcccgcgttt gccaggccgg agttaccgat
433261 ggcccccgac gaagagttga agaagccaga attgttggca ccggagttca ggaagccgga
433321 cgcgctaccg gcaccgctgt tgaagaatcc cgacgacggc gcactggtcg agttgaagaa
433381 gccggggctc ccgaaaatca ggccttggtg gtcgccgcgc cacaagaagc cgttgttgaa
433441 gttgccagta atgaaggcgc cggtgttgac attgccggag tttgccaagc cggtgttgta
433501 gttgccgctg ttcaggtagc ccgtgttgta ctggcccatg ttgaagccgc cggtattgct
433561 gttgcccggg ttgtagctac cggtgttgta gttgccggcg ttgccgacgc cggtgttggc
433621 tattccggag ttgaagaagc ccgtgttggc gtcgccggag ttgccaaaac cggtgttgta
433681 gctgttgccc gagttgccaa tgccccagtt cccggtaccc gagttgccga tgccgacgtt
433741 tccggtgccc gagttgaaca gaccgatgtt gccggtgccc gagttcaggc cgccgaaccc
433801 caacaaaccg ctacccgtga gcccgatacc tcggttgccg tctccggtat tgccgaagcc
433861 gatgttgttg ctgccggtgt tgccaaaccc gatgttgttg ctgccggtgt tgccgaaacc
433921 gatgttgttc agcgctgcgg tcaacccagg acccacgttg ccaaacccga tgttggagct
433981 gccgatgttg ccgctgccga tgttgccgtt gccgatgttg gccgagccga gattgaagtt
434041 cccgacatta ccgttgccga cgttgccctc gccgacgttc gccaagccca ggttgcggaa
434101 gacccgcgtg gtcacctgag ccgcggccgc gctgaccagc gcaccgccgc ccgccacggt
434161 cggcagcgcc tggccgaacg gtgtcaacgc cgagacggcc gccgaagccc cggcatggta
434221 gccaaacatc gccgccacgt cctgggccca catctgctcg taggcggcct cggtggccgc
434281 gatcgccggg gcgttttggc ccagcaggtt cgagaccacc agcgacacga acagtgcccg
434341 gttggccgag atgatcgccg gatgtaccgt cgccgccagg gctgcctcga aggcggccgc
434401 cgccagccgg gtttgggtgg ccgcctgctg ggcctgcgcc gccgccgcgc tcaaccagcc
434461 cagatagggg gcggccgctc ccgtcatcgc cgtcgacgcc gcgcccagcc acgaggaacc
434521 tgccagcccc gccgtcaccg ccgaaaacga ggccgcggcc gaacccaatt cgtcggccag
434581 tccatcccaa gcggccgccg cgtccagcat cggcgccaac ccggcaccca cgtacaggcg
434641 cgccgaattg atctccgggg gcagcaccgc gaagctcatc tagcgtccct aaccggaacc
434701 gctgaccacc accgcgtggt gggtggagcc aaacgtcccg ttccgcgctt gggtgtcttg
434761 acagtgacga ttattcaaca gacgcctgac gcaggtttgg ctttggagtg tcgagacaga
434821 aaatctcagc tagggctggc cgggcagtag ccgcaccatc aggccgttgc cttcggccaa
434881 cagcgtctcg tcgctgtcaa acagttccgc gcacacaaac gcctttcggc cctcggtatt
434941 ggtgactcgt ccgcgtacga tcaacggcac atcaatcggg gtgattcggc ggtaatcaac
435001 gtgcagaaag gcggtccggc tgatcggccg tcccgccgca tgcgagatca tgccgaacat
435061 gtgatcaaac aacagcggca acacgccgcc gtgcaccgcg gagttgcccc cgacgtgaaa
435121 ccggctaaac gacccccgca tctcaacacc gtcggtgccg taccgggtca ccgtccatgg
435181 cggtagcagc aggctgccca tgccgggcag gccgggggtc cgcccggccg gcgccttgcc
435241 ttcgtcggcc tcaaatgggc tcagcaactc gacgagcgcg gcggcgcgct cggccgcctc
435301 gtcccacacg gcgtcgccgg ggtccgccgc gaccgccagg tcctgcaacc ggcgcatggt
435361 cgccacgaac tggccgaacc ccgcaccggg actggccgga ccgtactccg gaaatccacc
435421 gtggtggtga tactcgggat cgagttcgtc ggggtgcact gacgcatctg tcacgggcga
435481 tcctgcagga cgtcccggcg cacgatggtc tgttcccgcc ccggaccgac tccaatgcac
435541 gaaaccggtg ctccggcaag ctgttccagt cgcagcacat aatcacgcgc tttggcgggc
435601 aggtcgtcga actcgcgcgc cccggagatg tcttcccacc agcccggcag ctcctcgtaa
435661 accggcttgg cgcggcaaag atcccgctgg gtcatcggca tatcgcgggt gcgccggccg
435721 tcgatctcat atccgacgca gaccggcacc gattccaggc tggacagcac gtcgagcttg
435781 gtcaggaagt agtcggtgat gccgttgacc cgggcggcgt agcgggcaat gacggcgtcg
435841 aaccagccgc agcgccggcg ccggccggtg gtcacaccga actcgcggcc agtcttggac
435901 aggtattcgc cgtgttcgtc gaacagctcg gtggggaacg ggccggagcc cacccgagtg
435961 gtgtaggcct tgagaatccc cagcacggtg ccgatgcggg tcgggccgat accagagccc
436021 acggccgcgc cacccgccgt cggattcgac gatgtcacat acgggtaggt gccgtggtcg
436081 acatcgagca gggtgccttg agagccttcc agcagcaccg tttcgccggc ctccagggca
436141 gcattgagta gcagccgggt gtcggcgatg cgatgcttga aaccctcggc ctgctccagc
436201 agcgcgtcga ccacctgcgc ggggtccagg gccttgcggt tgtagatctt gaccagcact
436261 tggttcttga actcgcacgc ggcctcgacc ttgtgggtca attgttccgg gtccagcaca
436321 tcggcgaccc ggatcccaat acgggcgatc ttgtcctggt agcacggccc gataccacgg
436381 ccggtggtgc cgatcttctt gctgcccata tagcgctcgg tgaccttgtc gatagcaatg
436441 tggtaaggca tcagcagatg ggcgtcggcg gagatcaaca gcttggcggt gtccacgccg
436501 cggtcttgca gtccccgcag ctcattgagc aggacaccgg gatcgatcac cacgccgttg
436561 ccgataacgt tggtgacccc gggcgtcagc acacccgacg ggatgagatg caatgcgaaa
436621 ttctcgccgg taggcaagac gacggtgtgc ccggcgttgt tgcccccctg atagcgcacc
436681 acccactgca cgcggccacc caacaggtcg gtggccttac ccttgccctc gtcgccccat
436741 tgggcgccga tgaggacgat cgccggcatg agttgctccc acctggtctc gcaggctatg
436801 cccgcttatt gtggtccagc cggtgaccta ccctacccag caggttgcga ggagctgtca
436861 tgtatacggc cgagaacgca cccggcgtcg cggtgttgct ctccggtgat gccgacgtgc
436921 ccggcccgtt gaccggcttg cctacccatc aagacaacct ggacaccgtc atcggacggt
436981 attcgcggct catcgtcgtc ggcgccgacg cggacctggg ggcggtactg actcggctgt
437041 tgcgcaccga ccggctcgac gtcgaggtgg gttatgtgcc gcgccggcgc agccccgcga
437101 cccgggccta ccgcttgccg gccgggcgcc gggcggcgcg gcgcgcccgg tgtggcgtcg
437161 ctcggcgggt gccgctaatc cgtgacgaga ccgggtcggt aatcgtcggc cgagcacagt
437221 ggctgccggc cgaagagcag gccctgatcc acggcgaggc ggtcgttgac gacaccgtgc
437281 tgttcgatgg cgatgtggcc ggggtgtgca tcgagccgac gctgaccctg ccaggcctgc
437341 gagctgcggt agacggcgcc ggaaagtggc ggcggtggat cggcgggcgc gccgcgcagc
437401 taggcaccac cggtgctgcg gtacttcggg acggtgtcgc ggcgccccgc ccggtgcgcc
437461 gatcgacgtt ttaccgcaac gtcgagggtt ggctgctggt ccggtagttt tcgaccggtg
437521 agcgagacgg gccagcgcga gtcggtgcga cccagcccga tctttctggg cctgctcgga
437581 ttgacggccg tcgggggcgc gctggcctgg ctggccgggg agacggtgca gccgctggcc
437641 tacgccgggg tgttcgtcat ggtgatcgcc ggctggctgg tgtcgctgtg cctgcacgag
437701 ttcggtcacg cgttcaccgc ttggcgtttc ggtgaccacg acgtcgcagt gcgcggctac
437761 ctgacgctgg atccccgccg ctacagccat cccatgctct cgctcggtct gccgatgctg
437821 ttcatcgccc tgggcgggat cggtctgccg ggtgccgcgg tgtatgtgca cacctggttc
437881 atgacgacgg cgcgccgcac cctggtcagt ttggcggggc cgacggtcaa cctggcgctg
437941 gccatgttgc tgctggcggc gacccggttg ttgttcgacc cgatccacgc ggtgttatgg
438001 gccggggtgg cgttcctagc attccttcag ctcaccgcgc tggtgttaaa cctgctaccc
438061 atcccgggtc tggacggcta tgcggccctg gagccgcacc tgagacccga gacgcagcgc
438121 gccctggcgc cggccaagca gttcgctttg gtgtttctgc tggtcctgtt cctggcgccg
438181 acgctgaacg ggtggttttt cggggtggtg tactggctct tcgacctgtc tggcgtgtcg
438241 caccggctgg ccgccgcggg cagcgtgctg gcccgtttct ggagtatctg gttctgaccg
438301 ttcagagccc aagcgccgga cgggccgcgg ggtcacagtc gtcaagcaga tccaggcagc
438361 gtccatactc gtcggtctcg ccgatagcgg ctgcggcgcg cgccagcgcc gccacacacc
438421 gtaggaaacc ccggttgggc tggtgggaat acggcaccgg gccgaagccc ttccagccat
438481 ggcggcgcag ctggtccagg ccgcggtggt acccggtacg cgcgtatgcg taggccgtga
438541 cggtcttgtc gtcggccagc gccccttcgg cgagcaccgc ccaggcgacc gacgccgacg
438601 gatgcgcggc cgcgacgatg ctcggacttt cgttggcaag cagctccgct tcggcgtcgc
438661 tgtcgccagg caacaggatt ggctcaggtc ccaagagatc acccatcgac gtcatgggag
438721 ttattgtgcg cttggtcacg tcacctcgac gatggggcca accgaaggct gggtcgctaa
438781 gctccaaaga gccactcgat accgggagga cagcagcacc catgtccaac gcacccgagc
438841 cagaccgctc agccggtgaa tccgggagcg aaccggccgg cgagcggtcc gccgatcctg
438901 gcgaggaacg caccgaaagc taccccctgg tgcctcacga cgccgaaacc gagaccgtgg
438961 tgatcaccac ctccgacaac gatgccgcgg ttacgcaacc ggaagcgcag cgcgaacgcc
439021 gtttcaccgc gcccggcttc gacgccaagg agacccaggt gatcgtcacg gcccacgagg
439081 cagccaccga ggttttccaa accaaccagg cgccgaccac cccgccgcgg atgccaaccg
439141 gaatgccccc gaaaactgct gtgccacaat caatcccgcc acggacggag gcgacgtcag
439201 tccggcaacg cacctggggc tgggcgctgg cggtggtagt gatcgtgctg gcgttggcgg
439261 caatcgcgat cctgggcacc gtgctgctga cccgcggcaa acattcgaag atgtcgcagg
439321 aagatcaggt gcggcaggcc atccagagct tggacatcgc catccagacc ggcgacctga
439381 ccgcgctgcg ttccctgact tgtggctcca cccgcgatgg ctacgtggat tatgacgagc
439441 gtgattgggc cgaaacctat cgccgggttt cggcggccaa acaatatccg gtcatcgcca
439501 gcatcgacca ggtcgtcgtc aacggcgcgc acgccgaggc caatgtcacc actttcatgg
439561 cgttcgatcc ccaggtccgc tcgacccgca gcctcgacct acagtttcgc gacgatcagt
439621 ggaagatctg ccagtcctcc agcaactgaa gccaggattg gctggtttgc ccgcattttg
439681 gccattggtc agtgctagga ccggtccgca tcaccggcac gtcaccagga ccgactagtc
439741 cgaacaccga aacgagcaac cgtagccgaa atgcggctgg atcccgtctg tggcaatgta
439801 ctggcggcct gttcccgcag agacggcggc atagcgtctc gatcgtcaac gagaggcagg
439861 tgatcgccag gtgagcatcc gccccgccga gaactcaaca ctcgacatcc gccacgtcat
439921 cggtatcggc accccgaaag ccgtcgattt gtggctcgac gtcgtcaccg agctgccgga
439981 tcgcgcccgc gaactcgggt cgttatccaa agccgaactc ggaaagcttg gcccactgct
440041 cgacggcacc aacgccgtcg agctattcga gtcgatcgac gacaagctgg ccgcagaggc
440101 actgcacgcg atggatccgt cgctggccgc caccttcctc gaggccctcg actccgacca
440161 cgccgccaac atcctgcgcg aattcaagga gcccaagcgg gaggcgctgc tgacgttgct
440221 accgctggag cgggcgatgg tgctgcgtgg cttgttgagc tggccggagg actgcgccgc
440281 ggcccacatg gtgcccgaaa cgctgaccgt acgcccgaac atgacggtgt cgcaggccgt
440341 cgccagcgtg cgggaacgcg cctcgggcct gcgcagcgat gcacgaacca ccgcctacgt
440401 ctatgtgaca gacgccgact cccacctgct gggtgtgatc gcctttcgcg ccctggtgct
440461 ggccaatccc gaacagcgag tccgtgagct gatgggtgac gacctcatcg tcgtgtcgcc
440521 gttgactgac aaggagctcg cggcgcagac aatcatgggc cacaacctga tggcggttcc
440581 cgtcgtcgat gccgacaacc ggctactggg catcatcgcc gaagacgaag ccatcgacat
440641 tgccgaggag gaagcaaccg aagacgccga gcgccagggt gggtcggccc cgctcgaggt
440701 gccctacctg cgggcgtcgc cgtggctgct atggcgcaag cgggtcgtct ggctcctggt
440761 actttttgct gccgaggcct acaccggcag cgtcctgcgg gcgttctccg acgaaatgga
440821 ggcggtgata gcgctcgcgt tcttcatccc actgctgatc ggcaccggcg gcaacaccgg
440881 cacccagatc gccaccactc tggtccgcgc gatggccacc ggtcaggtcc ggtttcgcga
440941 tgtgcctgcg gtgttagcca aggagctgtc aaccggtgtg ctggtcggcc tcactatggc
441001 cgccgccgcg gtggtgcgcg cctggacatt gggcgtgggc ccgcaggtga ccctgacggt
441061 cgcgctgacg gtggccgcca tcgtggtgtg gtcgtcgctg gtggctgccg tccttccgcc
441121 gctgctgaag aagttgcgca tcgacccggc catcgtttcg gggccgatga tcgccaccat
441181 cgttgacggc acgggtctgc tcatctactt cctggtcgcg cacctgacgc tgaccgagct
441241 gcacggcttg tgagcggccc cggtttagtg ggttagggac tttccggcgc agtgcaggtc
441301 attgcacgcc tgaacgaccc gctggctcat cgaagcttcg gccttcttga ggtagctgcg
441361 cgggtcgtag accttcttga cacccacctc gccatcgacc ttgagcactc cgtcgtagtt
441421 ggtgaacatg tgaccggcga tcgggcgggt gaacgcgtac tgggtgtcgg tgtcgacgtt
441481 catcttcacc acgccgtagc gcagcgcctc ctcgatctcc gacttaagcg aacccgagcc
441541 gccgtggaac acgaagtcga acggcttggc gtcggccggc agtccgagct tggccgccgc
441601 cacctgttgc ccttgcgcaa ggatgtcggg gcgaagcttg acgttgccgg gcttgtagac
441661 gccatgcacg ttgccgaacg tcgcggccag caggtatttg ccgtgctcac cggcgcccag
441721 cgcctcgatg gttttctcga agtcctccgg gctggtgtac agcttctcgt tgatctcgtt
441781 cgccacgccg tcctcttcgc cgccgacgac gccgatctcg atctccagaa tgatcttggc
441841 ggccgccgcc gccttgagca gctcctgggc gatggccagg ttctcatcga ttggcactgc
441901 cgagccgtcc cacatgtgcg actggaacaa aggattgcca cctttgctca cgcgttgcgc
441961 cgagatcgcc agcaagggcc ggacatagct gtccaacttg tccttggggc agtggtcggt
442021 gtgcagcgcc acgttgaccg ggtacttggc cgcgataacg tgggtgaact ccgccaaggc
442081 gaccgcaccg gtcaccatgt ctttgacccc gaggccggag ccgaattctg cgccaccggt
442141 cgagaactgg atgattccgt cactgccggc gtcggcgaaa cctttgatcg cggcgttgac
442201 ggtttccgag gaggtgcagt tgatagccgg gaaagcgtac gagttttgtt tggcctgacc
442261 gagcatctcc gcgtagacct cgggcgttgc gataggcatg aaacgttcct cctgacgact
442321 ccgatccacc cagtatcgca acaccgcaac cgagcttgtc ggcctgtgcg tgatggccgg
442381 tatgttggga cgtcatgagc accgccgtga cggccatgcc ggacatcctc gacccgatgt
442441 actggttggg cgccaacggc gtattcggtt ccgcggtgct gcccgggatt ttgatcatcg
442501 tcttcatcga gaccggtctg ctgtttccgc tgctgccggg cgagtcgctg ttgttcaccg
442561 gcgggctgtt gtccgctagc ccggcaccac cggtcaccat cggggtgctc gccccgtgcg
442621 ttgcgctggt cgcggtgctc ggcgatcaga ccgcatattt catcgggcga cggatcgggc
442681 cggcgctgtt caagaaggaa gactcccggt tcttcaagaa acactatgtg accgagtccc
442741 acgcgttttt tgagaagtac gggaaatgga cgataattct ggctcgattc gtgccgatcg
442801 cgcggacttt tgtgccagtc attgccgggg tgtcctacat gcggtatccg gtgttcctcg
442861 ggttcgacat cgtcggcgga gtcgcctggg gtgcgggtgt gacgttggcg ggctactttt
442921 tgggcagtgt cccgttcgtg cacatgaact ttcagctcat catcctggcc atcgtgttcg
442981 tctcactgtt gcccgcactg gtctcggcgg cgcgggtcta ccgggcgcgg cgtaacgcac
443041 cccagagcga ccccgacccg ttggtgttac ccgagtgagc tgaccgctgc ggcgctgtgg
443101 gcggcttcca tcagcatcca acccgatagc tgcaccgaca gatctcgctc ggcaatcgcc
443161 gagctatgca ccgctcctcg gacggaccgc gcctgctcac cgccggcggt gggcaactcg
443221 gcttcgcgat cccagaacgc cccgaacacc ggcaacccgt ccacggtttg ccggtaatcc
443281 cacgccgatt gcgcgctagc cagcactatc gcgcgggcgg tgtcgcgggc ggcggcgtcg
443341 tcggccgagt cgcccggcaa cgtggtggcg accaaggcga ggtatcgggc ggtgatcccc
443401 gcgaacaggc caccgtcccc gccgccggcg ccccgtaaca cacccaatgg agccatgtgc
443461 tcgttgacgg ccgcgaccaa gcgatgaacg cgagcgcagt gccgcgctct ggctgccgga
443521 ccggtgcgca ccgccagctc ggtttccagc ccgagcacca ccccttggca gtaggtgtac
443581 tgcgcgcgga ccaacgaccc ggccttgatg ccgtcgaata ccaggtgtgt ctccggatcg
443641 atcagcgtgc gatcgatcca gtcggccatc tgttctgcgc gcttgagcct tttcccgtac
443701 tggtctgggt agcgggccag gaatagcccg gccgggccgt tggctggggc gttgaagaac
443761 tggtcctgct tgcgccacgg gatgccgccg ccgtcctcgg gcacccaggc ttcgacgaac
443821 tggttggtga gcttgggcag tgcgcgccgg cgtcgtaccc cggcgacccg gtcggcacgt
443881 tccagcgcta acgctagcca cgccatgtcg tcgtaatagc tgttgagcca cgagaaattg
443941 ttgcggaccc ggtgcgagcg gacctggcgg ttgatccggg cgcgccgctg cggctgcggg
444001 tcgcgcagct gcgcgtcgac caggcaatcc agcaggtgtg cctgccacca gtagtgccag
444061 ctgccgaaca accggtcgcg ccgggttgac ggccaagcca ccaccgccaa ctgggtgccc
444121 ggcaacgccc aaagccgtct cagatgccgt tgcgtgacgg cggtttcggc gctggctgcc
444181 cggtttgcca gattcataat gcgatcctgc cctagcctgt cttacgccgt ctcaggcctg
444241 ttactccagc gtgacatcaa gggtggcggc gtccacgaag gccagcatgc gcgcccgatg
444301 atgccacccc cgctgaactg agcgacgatc cgcgggcccg cgagccggct gttgtcatag
444361 acggtggcgc cgtcggccag cgtgatggcc tgggcgacaa gctcggccag ccggcggtga
444421 cgctcgcgga tcttggtctc cggcacatcg tggccgcccg cggcgacgcg atgcctgacg
444481 cgctcgaccg ccaggccttc ggggataacc aacacgtgca gtacgacggt gtagccggcc
444541 gtgcgcgcgg tgcggatgag ctcgagcttc gatgggtgcg agaacaccgt ctcggcaatg
444601 aacggccggc ccaagtcgat gagcctcgcg cgggtgtcgg cggcgacctg cgccgcctgg
444661 taggcgtgcg atgttgggtc gtcgggccag cgttgtttgg cgatttcgtc ggcgttgacg
444721 aagacgatgc cgggcagcaa gggcgccagc gtgagggcga cgaacgtcga cttgccggcg
444781 ccgttgggcc cggcgaccag atcgagccgc ttcacgcgtg gcgcgttgtc ttcgagctgg
444841 cgatcacggc gtggccgcca gcacgaccga ggtgccgtct ggccggtgct cgacgatgtc
444901 gcccgcgtcg ttcagggcga ccgtggtgat gccctgcgcg gcgagcacgt cgccgtagtt
444961 ggttcgcgac aggcgctcct cgatagctgc ggagatctcg gcgttgaaca ccacgccctc
445021 ctccagcgtc aggtccgtca tcggcagatg ccccgcgagc gcagcttcca cgcggcgccg
445081 cgacgccgtg tgctggttcg acaccgcccg accgacgcgg gcccagtggt cgagctgctg
445141 cttggccgaa cggctctgac gagcaccctc ggccgccgcg ctgtccacca gatccgcggc
445201 gacgcgcgtg acgcggtcga cggctttggg cacgacatct ctcctcgggt gtagcgatct
445261 gttacagctt atagcaaagt gctacaccga gctgtggtga ggggcgcaca cggctagcgg
445321 gcaccggcca gcgccagcag caactggtgc aggccggcca gcgagtgcgc cggcaggaac
445381 aggtcgcaat agggcagcgc cgccgccatc gaaccggcac gcggctggaa ctccggatgt
445441 gccgcgcgag ggttcagcca gaccagcaac tcggcgcggc gacgcaccct ggtcagtgcg
445501 tgcaccaaca cgtcgggcgg atcgctgtcc cagccgtcgg aggcgatgat caccaccgcg
445561 ccgcgtaacg cgttgccatg cggcggggcc agcagggcgg cgacactacg gccgatgaac
445621 gtaccgccgt agcggtcggt caccctagcg ttggcccgat gtagcgccat ctcggccgag
445681 cgatgagaca gcaccgaggt aagtcgagtc agcgacgtcg aaaacgcgaa aacctccggg
445741 tggccccctg cccggcgcag caccgccgcc cgcatcagac gcagatagat ggcggcgtag
445801 ggctgcatcg agcggctcac atcgcagagc aggagcaccc gcctggggcg tcggcggggc
445861 cggatccgtg ccaacagcac cgactcccag ccagtcgacc gcgacgcgtt catcgtcgcc
445921 cgcaggtcga tgcgcttgcc gtgcgggctg gactcgaatc gcatgctgcg ccgccgcggc
445981 cagcgcgcca tcgtggcctc cagccaggcg ccgagcagac gcagatcgtc gggatcgaac
446041 tggtcgaatg gctcgtcggc ccgggcgaca atgcggctgg gcaggacatc gggcagtgtg
446101 cggctgggtc cgccctgacc ggcgctggcc atcgtcagcg agcgagtatc ccagggcaga
446161 ttctgggctt gggcggcaca agatcgccgc ttggcgcggt gcccgacgcc ggccaccggt
446221 gtgcgcgggc ctgcaatggg cggtggtggg cggttggcac cgtcgggttc ggcgctgcca
446281 aataccccga acagcgaagc gaataccgca tcgaacgtgg ccagttcgtc tacacggctg
446341 accagggtca accgcgcgcc ccaatacagc gccgccggcg tacgcggcac caactgctgc
446401 aacgcctgca ccaaactcgc ttgaccgctg gcggacaccg gtatcccggc gtcgcgaagg
446461 cgcgctgcca gcgctgccgc gaacgccgcg aggtcgacgc ccggcaacag tgcaggggtg
446521 gccatcccat tcatcgccgc cggcgcagca cccagatcag cagcagcacg gtcagcgccg
446581 ccagcagcgc cgaaccgtac tttttgagct ggccgccgtc ggccagctgc agcaagtcga
446641 tgggcgccgc ttcggtagca gggggtgtgc cttgcgggct ttctgaactc tgggccgcga
446701 gctcggcttc tagcgaatcc acgaactggc ccagcagctt ctccgacacc tgctgcagca
446761 tgccactgcc gaattgcgcc agtttgccga caatcttcag atcggtgtcg acggtgacgc
446821 gggtacgctc tccgacctcg tgcagctggg cagcgaccgt ggcggccgcg ttgccggtac
446881 cgcgcgcctc cttgcctttg gcgtcgaaaa cggcgcggtg ctggttgcgg tcctgctcga
446941 caaagtgcac cttgccgctg aactcgctgg tgaccggccc aaccttgacc ttgaccttac
447001 cgaggtactc gtcgccctca tggccgatca actgggctcc aggcatcagc ggaatcatct
447061 gctccaggtc gcatagcctg ctccaggcct gctcgatcgg agcgctgacg gtgaactcgt
447121 tggcgatctt catcctgtgc gtcctctcat gcgtggctgc actcagtaaa agcttggtac
447181 gcatcgcgaa tctgcgtacg gtcgtcgggc gttttggcca gggccccaag gctggccaga
447241 gcgggactcg aatccgctgc ggtgaggtct gcgaccccga gtgccaccaa agccgccacc
447301 cagtcgatag tctcggccac accgggtggc ttgtccagat cgagatcccg tgcagtgcaa
447361 acgaattgag tggcgttctc gatcaacggc gcggtagccc cgggcaccgt gcggcgcacg
447421 atcgcggccg cccggtccgg ccccgggtag tcgatccagt ggtagaggca gcgccgccgc
447481 agtgcgtcgt gcaggtcacg gctgcggttg gacgtgagca ccgcgatcgg cgggcactcc
447541 gcgaggaaag tgcccagctc gggaacggtc accgcggact caccaaggaa ctccagcagt
447601 aacgcctcga attcgtcgtc ggcccggtcg atttcatcga tgagcagcac tggaggggtc
447661 ggtccgcggt gccgcacgca ccgcaggatg ggccggtcca ccagatacgc ctcggtgtac
447721 agatccgctt ccgatatgtc tgagataccc ttgccgcgcg cctcggccag cctgatggac
447781 aatagctggc gttggtagtt ccagtcgtag agcgcctcgt tggccgtcag cccttcatag
447841 cattgcagcc ggatcagcgt ggtatccaac acgactgcaa gggttttcgc ggctgttgtc
447901 ttgccaacac cgggctcacc ctccaacaac agcggcctgc ccagcgtaac cgccagatag
447961 attgccgacg ccgtgccggt atccagcagg tagttctgtt cgtcgaaccg gcggatcacg
448021 tcgtcgggac ttgcgaaggt cacgagggca ccgattccag cagccgtcgg tagtcgtccc
448081 aggtgtccac gtcaagcggc acgcagccgt ccacggcgag ttcgcgcact gggtggcggc
448141 cggagtgcac cagcttccag acacccttgt cgccgtgcag tcgcgcgagt tcgccgaaca
448201 cggtgcggct aaaccagaat ggatgcccga cgccgtcggc gtagcggcac accatgatct
448261 cggtggccgg cccgacgtcg atgatccgcc gcagtgtcgc cggcgccacc tgaggctggt
448321 cgcccagcat cagcacgatc ccggtggccc gcggatgcac ccgtgccaac gcgacgcgca
448381 gcgatgccgc acacccgcgc tcgacatcct cgacgaccac cacgtcggtc ccgtccagcg
448441 ccatcgcggc acgcaccgcc gacgccgcac cgcccagggt gaggatcagc tggtcgaatc
448501 cggcttgccg ggcaacgtcg agggtggccc caagcaccgt ggtatcccga tatggcagta
448561 gctgtttggg cgtgcccaac cggttggagc gcccggcggc gagtaccaca ccggtgatct
448621 gggtcgcggt catgcgccgc cgttctcgtc cgccaacgcc ttccggcctc tggggccgcc
448681 gccgcgcagc gtggcgatca gttccgccgc aatcgacacc gcgatctccg ccggagtttt
448741 ggcgccgatg gccaatccga ccggggtatg cacccgggcc cgctcggcat cggacaggtc
448801 cagcgaatcc aggatggacg cgccgcgtac cgtgctggcc accagcccga catacccaac
448861 gccgttatcc agcgccgtgc ggatgatttc ggcttcgggc ccgccgtggc tggcgatcac
448921 aatcgcagtt ggcaaggcgt cggtgtcggc cggatcggtg tcgcggcgcg cgtcgtagcc
448981 caacaggccg cacagttcga tcaacgcgtc ggcgatcggg gtttcgccgt aaatctggat
449041 cagcggggcc ggcagctgcg gggtcaggaa gatctccagg gatccgccgg ccaggcacgg
449101 gttgaccacc acacacgccc cgggagcttc cgggaagtgc acgtcaccgt cgggcagcac
449161 gcgcagcagc acgctctcgc cggcctgcaa cacgcccatc gccgccttgc ggaccgagtt
449221 ctgcgcgcag tggccgccga caaagccctc gatggtgccg tccgccaaca ggattgcctc
449281 atcgcccggg cgggccgacg tgggctgctg ggcccgcacc acggtcgcgc gcacgaacgg
449341 tgtccgcgcg gccaccagct gtgcggcccg gtcactgatg gacatcgacg ccctcgagct
449401 cccctagatc ggtggtgtgg cccggccctg catggcctcc cagacccgcg acggcgtcaa
449461 cggcatgtcg gcgtgccgaa ccccgaacgg cgccaacgca tccaccaccg cgttcaccac
449521 cgccggcggg gaacccaccg tggccgactc accgatgccc ttggcgccga tcgggtgatg
449581 cggcgacggg gtcacggtgt gcccggtctc taggtgtggc acctcgagcg cggtcgggat
449641 caggtagtcc atcaacgatc cgcccagaca gttgccgtcc tcgtcgaagg caatcatctc
449701 catcagcgcc atgccgatgc cgtcgacgat gccgccgtgt acctgaccct cgatgatcat
449761 cgggttgatc cgggttccgc aatcatcgac ggccaaaaag cgccgcacct tcaccaccgc
449821 ggtgcccggg tcgatgtcga ccacacagaa gtaggcgccg tacgggtagg tcagattcga
449881 cgggttgtag cagacctcgg catccagccc gccctcgatg ccctcgggca gatcgccggc
449941 gccgtgcgcg cgcatcgcga tgtcggcgat ggtcaccgcg gccgacgggt cacccttgac
450001 gtggaacttc cctttctccc actgtaagtc ggcgaccgaa acctcgagca tgcccgaggc
450061 gatgatcttg gccttgtcgc gcaccttgcg ggcgaccagc gccgcggcac cacccgagac
450121 gggtgtggac cggctgccgt aggtgcccaa cccgaacggt gtctggtcgg tgtcgccgtg
450181 caccacctcg atgtcgtcgg gcgcaatccc cagctcctcg gcgacgatct gcgcgaacgt
450241 cgtctcgtgg ccctggccct gggtctgaac cgaaagccgc agcacggctt tgcccgtcgg
450301 gtgcacgcgc agctcgcagc cgtcggccat gcccaggccg aggatgtcca tgtccttgcg
450361 cggcccggcg cccacggcct cggtgaaaaa tgacatcccg atgcccatca gctcgccgcg
450421 cgctcgccgc tgcttttgtt cggcgcgtaa cgcctcgtag ccgatcatgt tcatcgcctt
450481 acgcattgtg gtctcgtagt cgcccgagtc gtacacccaa ccagtcttgc tctgatacgg
450541 aaactggttg ggccgcaata gattccgcaa gcgcagctcg gctggatcca tcttcagctc
450601 gaaggccagg cagtccacca gccgctcgac gaagtagacc gcttcggtga tgcggaacga
450661 acacgcgtag gcgaccccgc cgggcgcctt gttggtatac accgcggtca tgtgacagta
450721 ggcggcctcg atgtcgtagc tgccggtgaa caccccgaag aacccggctg ggtacttcgc
450781 cggcgcggcc tgggcgttaa acgcaccatg gtcggccagc acattggacc ggatcgccag
450841 gatcttgccg tcacggttgg cggcaatctc gccgaccatg atgtagtcgc gggcgaatcc
450901 ggtggacgtc aggttctcgc tgcggtcctc catccatttg accggcttgt ccagcagcag
450961 cgacgcgaca atggcacaga cataaccggg atagatcggc accttgttgc cgaagccgcc
451021 gccgatgtcg ggcgagatca cccgaatctt gtgttcgggc aacccggcca ccagcgcgta
451081 tagcgtgcga tgcgcgtgcg gcgcctggct ggtggtccac agcgtcagct ttccggtgac
451141 cggatctaga tcggccaccg cgccacaggt ttccatcggc gccgggtgca cccgcgggta
451201 gacgatctcc tgctggacaa cgacgtcggc cttggcgaac accgcctcgg tcgccgccgc
451261 gtcgccggtc tcccagtcga agatgtgatt gtcgctcttt ccctccagat cggtgcggat
451321 gaccggcgcc gacgggtcca gcgccgtgcg ggcatccacg acgggatccc gcggttcgta
451381 gtcgacgtcg accaactcgc atgcatcgcg ggccgaatac cggtcctcgg caaccacgaa
451441 cgccacctct tggccctgga agcgcgtctt gtcggtggcc agcacggctt gtacgtcgtt
451501 ggctagtgtc ggcatccaag ccaggccctt ggcggccaga tcggcgccgg tcaccacggc
451561 cttgactttc ggatgtgcct gcgcggcagt cacatcgatg cgcacgatgc gggcatgcgc
451621 atacggcgaa cgcaggatgg ccagatgcaa catgcccggc agcgcgacgt cgtcgacgta
451681 ggttccgcgc ccgcggatga atcgcgggtc ctctttgcgc atcatccggc cgtgcccgca
451741 cggctgctga gcgttgtcgg ctaggtcttc cggcgacgga gggcgtgact cgatcgttgt
451801 catgactgcg cctttacggt ctggtgcgct gccgcccact gaatggagcg cacgatcgtg
451861 gtgtatccgg tgcaccggca gatctgcccc gagatcgctt cccggatggt ctgctcgtcg
451921 ggatccgggt tgcggtccag cagggcgcgc gcggtaatca gcattcccgg ggtgcagaag
451981 ccgcattgca gcccgtggca gcgcatgaac ccttcctgca ccgggtcgag ctggccgtcg
452041 ggcccagcca agccctctac cgtgcggatg ctgtgcccgg aggccatcac ggcgagcatc
452101 gtgcaggatt tcaccggcac gccgtcgacc tccaccacgc atgtcccgca gttgctggta
452161 tcacagcccc agtgagttcc ggtgagccgc agctgatcac ggagaaaatg gaccagcagc
452221 atccggggtt cgacctcggc ggtgacgggc tcgccgttta ccgtcatgtt cacctgcatg
452281 gttggttccc ctctcaggcc tcgggggccg ccggcgcgcc gagcacgcgc ccggcggcgg
452341 tgcgcagcgt gcgaacggtc agttcaccgg cgaggtgccg cttgtactcc gcggtgccgc
452401 ggacgtcggt caccggcgtg caagcttgcg cggcgcgccg gcccgcctca gcgaacacct
452461 cttcggtagc gggttggccg accagtcccg cggacagctc cgccagcgcg accgggtcgg
452521 gattcaccgc ggtcaaaccc acccgagcgg cgaggatcgt ctggccgtcg agcgtgaccg
452581 cggcaccggc cgcggtgatg gcccagtcgc cgacccgccg ttccaccttg gcgtacgcgc
452641 tggaggtgtt gtgccgcagc ggaatccgca cctcaattag gacctcgttg tgggcgagcg
452701 cggtttcgta cggcccgacc aggaagtcgt cgatcgctat ctcacgttca cccgagggcc
452761 ctttcgccag gcacaccgca tccagaacgg tgcacacggt cgacaggtcc tcggccggat
452821 ccgcctggca gagcgaaccg cccagggtgc cgcggttgcg gaccaccggg tcggcgatca
452881 cccgctcggc atcgcggaag atcgggcaca ccgccgccag cgcatcggag tccagaatct
452941 ctcgatggcg ggtcatcgca cccagccgaa ccaggttggg attgttgatt ccgccgacca
453001 cgacgtagcc gagttcgggg gccaggtcgt tgatgtccac gaggtactcg gggttggcga
453061 tgcgcagctt catcatcggc agcaggctgt gcccgccggc gaccacccgc gctccctccc
453121 ccaaccgatc caacaatccg atggcgtggt ccacgctggt ggcacgttcg tattcgaaag
453181 gcccaggtac ttgcatgcgc cccagtgtcg gccgcccgcg aaaagggcgt caatgtcgag
453241 ttaagtaatc cttgaactcg cccgctacct gcgcatcatg gtggatccgt ccggcaatat
453301 cggccagcgg gcgtccccct ccgccccaac gtcgggcgat gatgtcggcc gcgatcgaga
453361 ccgcggtctc ctcgggggtt cgggcaccga gatccagccc gatcgggctg gacaaccggc
453421 tcagctcggc gtcggtcagg cccgccgcgc gtagccgatc catccggtcg tcgtgcgtct
453481 tgcgtgatcc catcgccccc acgtatccga cacccaggcg cagcgccacc tcgagcaccg
453541 ggacgtcgaa cttcggatcg tgggtgagca cgcagatcac cgtgcgctcg tcgataccac
453601 ccgcctccgc ctgggcagcc agatagcggt ggggccatgc gacgacgacg tcatcggccg
453661 tcggaaagcg cgctggcgtg gcgaataccg cgcgggcgtc gcagacggtg acccggtagc
453721 cgaggaacga accctgccgc gccagcgcgg cggcgaagtc gatggcaccg aacaccagca
453781 tccgcgggcg cggcgcgtgg ctggacacga agacctccat gccctcgcca cgccgctgcc
453841 catcgggccc atattcgagg atctcgctgc ggcccaccgc gagcagaccc cgcgcatcgt
453901 cgataaccgc cgcatcggca cgcgccgaac ccagcgaacc cgtcacgggg ctctttgtgt
453961 cgggccggat caccagtcgg cgacccaccc gccgctcgtc cggatgggcg atgacggtcg
454021 cgatggcgac cgggcgttgc gcgccgatgt cgtcggccag ctcgcccagc tcgggaaacg
454081 tggcccgcga tacgggctcg acgaagacgt cgatgatgcc gccacaggtc aggcctaccg
454141 cgaatgcggt atcgtcgctg actccgtagt gttccagccg cggtatcccg gtttgggcca
454201 cctcggcggc cagctcatat accgcaccct ccacgcagcc gcccgacacc gacccactta
454261 ccgaaccgtc cggggctacc accatcgcgg cccctggggg ccgcggcgct gaccgcaagg
454321 ttcgcaccac cgtcgcgacc cccgcggtgt caccggcggc ccagatcgcc atcagctcgg
454381 caagcacttc acgcacgctt cccaaagtag gcttcagtgc atgaccccgg ctcaacttcg
454441 ggcctattcg gcggtggttc gcctgggctc ggtacgggcg gccgccgcgg aactcggtct
454501 ttccgacgcc ggagtctcca tgcacgtcgc ggcgctgcgc aaggaactcg acgacccgct
454561 gtttaccagg accggtgccg ggctggcgtt cacgcccggc gggctgcggc tggccagccg
454621 cgcggtcgaa atcctgggcc tgcaacaaca aaccgcgatc gaggtcaccg aggccgccca
454681 cgggcgtcgg ttgctgcgca tcgccgcctc cagcgccttc gccgaacacg ccgcgccggg
454741 cctgatcgag ctcttctcgt ctcgggccga cgacctttcg gtcgagttga gcgtgcatcc
454801 caccagccgg ttccgcgaac tgatctgctc gcgcgccgtc gacatcgcga tcggcccggc
454861 cagtgagagc tcgatcggtt ccgacggctc gatctttcta cggcccttcc tgaagtatca
454921 gatcatcacc gtcgtcgcgc cgaatagccc actggccgca ggcattccga tgcccgcgct
454981 gttgcgtcac cagcaatgga tgttgggtcc gtccgccggc agcgtagatg gtgagatcgc
455041 aaccatgttg cgcggcttgg cgattccgga gtcccagcaa cggatcttcc agagcgatgc
455101 cgccgcgctg gaggaggtca tgcgcgtcgg gggcgccacg ctggccattg gctttgcggt
455161 cgccaaggat cttgccgccg gacggttggt gcacgtgacc ggtcctgggc tggatcgcgc
455221 cggcgagtgg tgtgtggcga cattggcgcc ttcggcccgc caacccgccg tctccgagct
455281 tgttggcttc atcagcaccc cgaggtgtat tcaggcgatg atcccgggta gcggggtcgg
455341 ggtgacgcgg ttccgcccaa aggtccacgt caccctgtgg agctagctac ttcgacttga
455401 aaggctcggc gcgccggtcc gcccgttgac ggggcccggc tgcgaggatt agccagttcc
455461 cttgtcgcac aggagcgttg aggctatcgc cgtacgccta ctgcgtgcga tcagcgcttg
455521 ctcgttccat accacagggt gcggcccagg tgcaaggttc actgtgcatc gtgcgctgga
455581 gcctttggtg cctgttgccc gttgaaccgt gatccagcgc ggctgagggt gtggtggtgt
455641 cgggccgctg ggaggccggg aatgcggacg gtaacggtgg ctccgcgggg ttgatcggca
455701 gcggcggggc cggcggcgac ggcggtagcg gcggggccac cggcgccggt ggcgaaggtg
455761 gcgatgctgg agcaagcggg tccataaacg gcaacgccgg cgaccccggc aacagcggag
455821 aacgcggcgc agtgggcaag cccggcgcac ccggctgacc cgaaaatcac cgcatcaccg
455881 ggctcgctca caaccgagag cggacgcggg ctcggcgggc tagacgaatc gacgcgccaa
455941 ctttctcgga tcgaagaagc tatacgcttt acccccatga gtgtgtacaa ggtgatcgac
456001 atcatcggga ccagccccac atcctgggaa caggcggcgg cggaggcggt ccagcgggcg
456061 cgggatagcg tcgatgacat ccgcgtcgct cgggtcattg agcaggacat ggccgtggac
456121 agcgccggca agatcaccta ccgcatcaag ctcgaagtgt cgttcaagat gaggccggcg
456181 caaccgcgct agcacgggcc ggcgagcaga cgcaaaatcg cacggtttgc ggttgattcg
456241 tgcgattttg tgtctgctcg ccgaggccta ccaggcgcgg cccaggtccg cgtgctgccg
456301 tatccaggcg tgcatcgcga ttccggcggc cacgccggcg ttaatgcttc gcgtcgaccc
456361 gaactgggcg atcgacaccg tgaccgccgc gccggcacgg gcgtcgtcgg taatgccggg
456421 cccttcctgg ccgaataaca gcaggcattc ccgcggcaac gcggtctgct ccaggcgcgc
456481 cgcacccggg acgttgtcca ccgccaccac ggtcaagccg gcgcccgccg cgaactccag
456541 cagcccggtg gtgctgtcgt ggtggcataa ccgctgatag cggtcggtca ccatggcgcc
456601 gcgccgattc caccgccgac gcccgacgat gtgcacggtg tgcacggcga atgcattggc
456661 ggtgcgcacc accgagccga tattggcatc gtgtccgaag ttctcgatcg ccacgtgcaa
456721 ggggtgacgg cgcgtatcga tgtcggcgat gatcgcctct cgggtccagt accggtaggc
456781 gtcgacgacg ttgcgagcat cgccgtcgcg caacaacacc gggtcgtatc gggggtcgtc
456841 cgggaggtcg cctgcccagg gccccacgcc gccggtcggc gcgccccatt ccgtaggccc
456901 gggcccaagc gcactcatcg cgaggtccac aacgcggcgt gggttcccac tgtcgcgacc
456961 gtcgcgtaca gcaacgcctc gttgatctcg ccctgcgtac acagcgacgc gctaatgtgg
457021 accgcgtcca gtagcgcgtc aggaaggatc agcaccgagg atccatacgt cgcgcacgcc
457081 gggctcagtc cgcggccggg cagtgtcggt gcggcgagca gcatcatggg accgccgcgg
457141 gcagcggagt cgtcccgata ccgatccggg acggcgtcga cctccagccc cagcagcatg
457201 tagccattac cggtgaacgc caccggatct ccgagctggg gcttacccag ctgcatgccg
457261 tcggcgcgcc aagccgagac gctggtggtc ttgaccacca gaccggcgtc gttttgattg
457321 gtcggcagca tccccaccgg aaacgcggcc ggataggccg cggcagtacc cgggatccga
457381 tcgcggggcg agtacgtgta cacgccgcgg acggcgcttc gctctttcag cggacccagg
457441 cagaccgtgc ctgtgagccg gccggcaggc gccgatagcg gcgacacgac gtcgcgcacg
457501 tgggccatcg cgtcgccgca gctgccgagc gcagcggatt ccatcggatg ggccaacgcg
457561 ccgtacagcc cgaagcgaat gtcttcgggc ttggcgtgcg gcgcatgcgg gtccgtcggg
457621 gatgcatcca cgtcgatgag cacatagtcg ccggaccagc gcagattcga caccgacatg
457681 ttccagccca gcaccgccag cgattcgccg gtccgggcgc tctgggcgcc gtaggtgcga
457741 ccggaatgac tcgaacccga gcagcccgtc agaccggaca ggacgacggc cccgcaggtg
457801 gcccaggcaa cgagaatgcg cacagcgatg ccgccgacgc ctaatccagc cccagatcgg
457861 ccaggcccag cacgctgcgg tagcgcagtc cctcggcttc gatagcctct gcggccccgg
457921 tggcgcgatc caccacggta gccacgccga caacctcacc acccacgtct tggacggcgt
457981 gcaccgccgt cagcgcggag ttaccggtgg tactggtgtc ctctaccacc agcacccgct
458041 gcccggtaac ctccgaccct tcgataagtc gctgcatgcc atgggctttc gccgacttgc
458101 ggaccacgaa cgcgtcgatc ggacggcccg gggcatgcat gatggcggtc gccacgggat
458161 cggccccgag tgtcaggccg ccgacaaccg aatagtccca gtcggcagtg agttcgcgca
458221 ttagccggcc gatcagcgcg gacgcccgat ggtgcaaggt ggcgcgacgc aggtcgacgt
458281 agtagtcggc ctcccggcca gacgacagcg tgacgcggcc gtgcaccacc gacagccggc
458341 gcaccaactc agccaactct gcgcggtcag gtccggccac ggcttctcct cacgccgcca
458401 cgcgggaggc cgatcacatg cggcgtcacc gcggtggcct cgggcgtgac atccgcggtc
458461 tcagtgttgg tagttggtgg cctgctggcc gttgcgtccg gccggcggcg ggcgccgaac
458521 gccttcggag cggccttcat cgcggcggat cggctcgggg gcccgacgag ccggatcggg
458581 cagcaccgtg gttgccggat ccggctgggc gcgccgcggc ggtaactccg cggggccgcc
458641 cggggccacg ggtcggccag gtgccgcgcc gcgcggtccc accccggttt gttggggcat
458701 ctcctgcggc agcggcggca acacgcgcag caagtcgttg aattggcgca cggtgcgcag
458761 gccctcgtcc cactgggcac gggtgctggc aatcggcatg ctgaccagcg tccagttctg
458821 ctcgttccac atgatttcgg cgcagtcggg cgcggtgtgc gcgaaggtga ccatccgccg
458881 atcgcaggcg cgccgggccg cgtctagatt ggtggagtac accatccgtg gcccgatcgc
458941 gcccagcagc cagatgtcgc tttctcgtgg ctctttcagg cctttgagcc gcaggtcgac
459001 cacgacattg gtgcccacct tgcgatgcag cgcgatcacg gtggcgactt cctcgagatc
459061 gaagatgtac accgcctcgc cgcggatctg acccagcacc acgttatggg cggcaacatc
459121 gccaactgtg gacatcacgc cgcgcgtcca gcgcttgagt atctcggtgg attcccgttc
459181 gtagtcgaac ccgtgcgatc gcgcccacga cttgcggcgt ctgctgcgcc cgcggcgtcg
459241 atcgatgtcg acgtacagca acaccacggc accgacgaag cacagtgccg agagcgtgaa
459301 ccaaagcggg accatcggtg cttagcctat ccgctggcgg cccggaaccg agaatgcgac
459361 caggtcacaa cccagtcacc ttccacgccg agcagacgag gaatcgcact gcgcggacct
459421 cacgcgtgcg attccgcgtc tgctcgtcag acaaatcagc ccaggatcag cgagtcggcg
459481 tcggggctga cgttgaccgg cacggtatcg ccgtcgtgca cctggccggc caacagcatc
459541 ttggccagct ggtcaccgat ggcctgctgc accagccggc gcaacggccg cgccccgtac
459601 accgggtcga atccgcgctg cgccaaccag cgcttggccg gcagcgagac ctgcagctgc
459661 agccgccgct gcgccagccg cttgcccagc tgcgccagct ggatgtcgac gatgcgcacc
459721 agctcttcgg ggttgagacc ctcaaagatg agcacgtcgt cgagccggtt gatgaactcc
459781 ggcttgaacg tagcgcgcac cgcggccagc acctgctcgg cgctgccacc cgaccccagg
459841 ttggacgtca ggatcaagat ggtgttgcgg aagtcgaccg tgcggccgtg cccgtcggtg
459901 agccggccct cgtcgaggac ctgcagcagc acgtcgaaca cgtccgggtg cgccttctcg
459961 atctcgtcga acagcaccac cgtgtaggga cgccggcgca ccgcctcggt cagctgaccg
460021 cccgcctcgt atcccacata gccgggcggg gcgccgatca accgagccac ggtgtgcttc
460081 tcgccgtact cgctcatgtc gatgcggacc atcgcccgct cgtcgtcgaa caggaagtcg
460141 gccagcgcct tggccagctc ggtcttgccg acaccggtcg ggccgaggaa catgaacgcc
460201 ccggtgggcc ggttggggtc ggacaccccg gcccggctgc gccgcaccgc atcagagact
460261 gcggtaaccg cggccttctg cccgatgacc cgcttgccca gctcgtcttc catgcgcagc
460321 agcttggcgg tctcgccttc cagcagccga ccggccggga tgccggtcca cgccgacacc
460381 acgtcggcga tgtcgtcggg accgacctcc tccttgagca tcacctgctc ccgggcctgc
460441 gcctgcggca acgccgcgtc gagcttcttc tccacctcgg ggatgcgtcc gtagcgcagc
460501 tcggcggcct tggccaggtc gccgtcgcgt tcggcccgct cggattcccc gcgcagggct
460561 tccagctgct ccttgaggtc gcggacgatt tcgatcgcgt tcttctcgtt ctgccagcgg
460621 gtggtgagct cggccaactt ctctttctgg tcggccagct cggagcgcag cttggccaac
460681 cgctccgccg acgcctcgtc ttcttctttg gacagcgcca tctcttcgat ctccagccgg
460741 cgcaccagcc gctcgacctc gtcgatctcg acgggccgcg agtcgatctc catccgcagc
460801 cggctggccg cctcgtcgac caggtcgatg gccttgtcgg gcaggaagcg ggcggtgata
460861 taccggtcgc tcaaagtggc agctgccacc agcgccgagt cggtgatgcg caccccgtgg
460921 tgcacctcgt agcggtcttt gagcccgcgc aggatgccga tggtgtcctc caccgacggc
460981 tcgccgacgt acacctgttg gaaacggcgc tcgagcgcgg cgtccttctc gatgtgcttg
461041 cggtattcgt ccagcgtggt cgccccgacc agccgtaact cgccgcgggc cagcatcggc
461101 ttgatcatgt tgccggcgtc catcgccccc tcgccggtgg cgccggcgcc gacgatggtg
461161 tgcagctcgt cgatgaacgt gatgatttgg ccggccgagt tcttgatgtc gtcgaggacg
461221 gccttgagcc gttcctcgaa ttcgccgcgg tatttggagc cggcgaccat cgagccgaga
461281 tcgagcgcga cgatggtctt gtcgcgcaag ctctccggca cgtcgccggc cacgatgcgc
461341 tgcgccaggc cctccacgat cgcggtcttg ccgacgccgg gctcaccgat cagcaccggg
461401 ttgttcttgg tgcgacggga cagcacctgc accacgcggc ggatctcgtt gtcgcggccg
461461 atgaccgggt cgagtttgcc ttcgcgggcg cgggcggtca ggtcggtgga gtacttctgc
461521 agcgcctgat aggtcgcctc cggttcgggg ctggtgaccc gggcgctgcc gcgcaccttg
461581 acgaacgcct cccgcagcgc ctgcggcgag gcgccgtggc cggtcaacag cttggcgacg
461641 tcggagtcac cggtggccag cccgaccatc acgtgctcgg tggagacgta ctcgtcgtcc
461701 agctcggtgg ccagctgctg cgcggtggtg atcgccgcta acgactcgcg ggacagctgc
461761 ggctgcgtgc tggctccagt cgcctgcggc aaacggtcga gcaggcgctg ggtttcggcg
461821 cggacggtgg cgggctcgac accgacagcc tccagtagcg gtgcggcgat accgtcgttt
461881 tgggtcagca gcgccatcag caggtgagcg ggccggatct cgggattgcc ggcggtcgaa
461941 gccgcctgta acgccgcggt tagcgccgcc tgcgtcttgg tcgtcgggtt aaacgagtcc
462001 acgacacctc cattcggggt ccgttcgaaa tgcttgtcgg gttgttcaac gccgtcaatg
462061 ttgagtctgt tccgctcaat tttacccact tgtgcatccg ccgccgtttc gccgcgagct
462121 tagaatcgag gtccgtgggc ctcgaggacc gggacgcgtt gcgggtgttg caaaacgcct
462181 tcaagctcga cgacccggaa ctggtccgcc gcttctatgc ccattggttt gccctcgacg
462241 cctcggtacg cgacctgttc ccacccgaca tgggcgccca gcgagccgct ttcgggcagg
462301 cgctgcactg ggtgtacggc gagctggtgg cgcagcgcgc cgaggaaccg gtggcctttc
462361 ttgcccagct cggccgcgac caccgcaaat acggtgtgct gccaacccag tacgacacgt
462421 tgcgccgcgc gctgtatacg accctgcgtg actatctggg ccatccaagc cggggcgcct
462481 ggacggacgc cgtcgacgag gccgccggcc agtcgctcaa cctgatcatc ggggtgatga
462541 gcggtgccgc ggacgccgat gacgcgcccg cctggtggga cggcacggtc gtcgagcaca
462601 tccgggtgtc acgcgacctt gctgtcgctc ggctgcagct ggaccgcccg ctgcactatt
462661 accctggcca atacgtcaac gtgcatgttc cgcaatgccc ccgccggtgg cgatatctca
462721 gcccagccat tccggccgac ccgaacgggc ggatcgagtt tcacgtccgg gtggttcccg
462781 gtggcctggt cagcaacgcc atcgtgggtg aaactcggcc cggtgaccgg tggcgattgt
462841 ccggtccgca cggagccttt cgggtggacc gcgacggcgg cgacgtgctc atggtcgccg
462901 gtagcaccgg gctggcgccg ctgcgggcgc tgatcatcga cctcagccgc ttcgcggtga
462961 atccgcgcgt gcacctgttc ttcggagcac gctatgcctg cgaactctac gacctgccca
463021 cgctgtggca gatcgcggcg cacaatccgt ggctgtcggt ctcgccggtg tcggagtaca
463081 acggtgatcc ggcttgggcc gccgactatc ccgacgtgtc ggcgccgcgc ggtctgcacg
463141 tgcgccagac cggccgacta cccgatgtgg tctcccgata cggcggctgg ggcgatcggc
463201 agattctgat ctgcggtgga ccggccatgg tccgcgccac caaggccgcc ctgatcgcca
463261 aaggcgcgcc accggagcgc attcagcacg acccactgtc gcgctagccg ggcggaaatc
463321 caccgtccgg tggcgtcgct tcgacatggc atacggcctt tgctacccgg tcaccgctgg
463381 ctagcatgag tgcgactgag tggagcgggg atgagcaagt tgctgccacg gggcacagtg
463441 acattgctgt tggccgacgt cgagggatcc acctggctgt gggagaccca tccagacgac
463501 atgggtgctg ccgtggcgcg cctcgacaaa gccgtgtctg gtgtgattgc cgcccatgac
463561 ggcgtacgcc cagtcgagca gggtgagggt gatagctttg tcctcgcgtt cgcctgcgcg
463621 tcggatgccg tggccgccgc gttggacttg cagcgagcgc ggctcgcacc gatccggttg
463681 cgcataggcg tgcacaccgg ggaggtcgcg ctccgcgacg aaggcaacta tgccggtccg
463741 accatcaacc ggaccgcgcg cctgcgtgac ttggcgcatg ggggccagac ggtgctctcg
463801 ggcgtgaccg aaagcctggt catcgatcgc ctcccggaca aagcatggct ggttgacctg
463861 gggacgcacg cgctgcggga tctgtcgcgt ccggagcggg taatgcagct gtgtcatccc
463921 gaattgcgta tcgatttccc gccgctgcgg gtggccaatg acgatgtggc ccatggtctt
463981 ccggtgcacc tgacgcgttt tgtggggcgc ggcgcgcaga tcaccgaggt gcaccggttg
464041 gtgaccgata accggttggt gaccctgacc ggcgccggcg gcgtgggcaa gacacggctg
464101 gcggcgcagc tcgcggcgca gatcgccggt gagttcggtc gcgcgtggtt cgtggatctg
464161 gcgccgatca cggaccccga cttggtgccg gtcacggtgg cgggcgcgct gggactgcac
464221 gaccagccgg gccgctccac gacggacacc gtgctgcgct ttcttggcgg gcgtccagcc
464281 ctggtggtgc tggataactg cgagcacctg ctggatgcga cggcggcctt ggtgttagcg
464341 ctggtgaaag cgtgccgggg ggtgaggttg ctggcaactt gtcgtgagcc gctccgggtc
464401 gagggtgagg tgagctaccg ggtgccgtcg ctgtcactga gcgatgaagc cgttgagatg
464461 ttttgctacc gggctcagcg agtccggccg gactttcgcc tcaccgacga caactccgcc
464521 gcagtgaccg agatctgcaa acggctggac ggtttgccgc tggcgatcga gctggcggct
464581 gcgcggctgc ggtcgatgac gcttgacgag atcatcgatg gcttgcgtga ccggttcgcg
464641 ctgttgaccg gcggtgcgcg cacggccgcg caccggcagc agacgctgtg ggcctcggtg
464701 gattggtcgt acacgctatt gaccgagccg gaacgtacct tgtttcgccg gcttgcggtg
464761 tttgtgggtt gcttttttgt cgacgacgca caggcggttg cctgcagcgg cgatgtgcag
464821 cgctaccagg tccttgacga gatcaccctg ctggtcgaca agtcactggt gatggccgac
464881 gacaacagcg gccggacgtg ctatcggtta tgcgagacga tgcgccacta cgcgttggaa
464941 aaactctccg aggctggcga ggtggacgcc gtgtttgcgc ggcaccgtga ctactacacg
465001 gcgctggctg ccagggtcga caatcccgga ccctccgatt attcgcactg cctcgaccaa
465061 gccgaaaccg agatcgacaa cctacgtgcc gcctttgtgt ggaaccggga aaattccgac
465121 accgagggcg ccttggcgct ggcgtcctcc ctgttgcggg tatggatgac gcgggggcgc
465181 atccaggagg ggcgcgcctg gtttgacagc attcttgccg acgagaatgc gcgtcatctc
465241 gaggtggcgg ccgcggtgcg cgcccgggca ttggccgaca aggccctgct cgacatcttc
465301 gtcgacgccg ccgccggtat ggagcaggcc caacaggctt tggtgatcgc gcgcgaggtc
465361 gatgaaccgg cgctgctgtc ccgggcgctc acggcctgcg gcttgatcgc ggtagcggta
465421 gctcgcgccg atgcggccgc gtcttatttc gccgaggcga tcgacctggc acgagcggta
465481 gacgaccggt ggaggctggc ccagatcctt acctttcagg cggtcgatgc ggtcgtggcg
465541 ggtgacccgg tcgcggcacg cccggccgcc caagaggcac gcgagctggc tgccgcgatc
465601 ggtgaccact ccaatgcgct gtggtgccgc tggtgtctcg gctacgccca gctgatgcgg
465661 ggggagctgg ccgcggccgc cgcccaattc ggcgaggtgg tggacgaggc cgaggcgtct
465721 caggaagtgc tgcacaaggc caacagcctg cagggcctgg ccttcgcgct cgcctaccag
465781 ggtgaattga gtgcggctag ggcggcggcc gacgccgctc tcgaggccgc cgagctgggc
465841 gagtacttcg cgggtatggg ctactcggcg ttgaccacgg ccgcgttggc cgccggcgac
465901 gtgcagacgg ctcaacatgc cagcgaggcg gcctggcgga acttgagttt ggcgctgccc
465961 ctctcggcag cggtgcagcg cgcgttcaat gcccaggctg cactggctgg tggtgacctt
466021 agcgcagcgc gtcgttggtg tgacgatgcc gtgcagtcaa tgaccggcca tcatctggcg
466081 atggcgctgg cgactcgcgc caggatcgcg gtcgccgagg gcaagcggga agaagccgaa
466141 cgcgacgcgc ataaggcgct cgcgtgcgcg gccgagagcg gggcacacct ggatctcccc
466201 gacgtgctcg aatgccttgc cggcctggcc agcgacgccg gcacccacca tgcggcggca
466261 cgactcttcg gcgccgccga ggctatccga cagcagatcg gctcggtccg cttcgcgatt
466321 taccgttcgg actatgtgca gtcggtgacg gctctgcgag atgcgatggg ggagaaagac
466381 ttcgacgctg catgggccga aggtgccgcg ttgtcgatca aggagacgat cgcctatgcg
466441 caacgtggcc actcctggcg caaacgaccg gccaccggtt gggaatcgct tactccgacc
466501 gagattgacg tcgtgcgact ggttggcgag ggactggcca acaaggacat cgcgacgcgg
466561 cttttcgtct caccgcgaac agtgcaaacg cacctgacgc acgtctacac caaactcggc
466621 ttcacctcgc gactgcaact cgctcaagcg gccgcccgcc gtacctgagt gctattgatt
466681 ggcgttcggg gacggcggta ccacgatgat ggtcgctccg gggatcgccg ccagggtcgc
466741 cgcaaggttg gcaaccacgc cgggcggcaa accgggcggt aggccaggta tggctgaccc
466801 ggcggccgcc gcggggaccg cgggcgtctg ctgggcggcg ggcctggtgg cagccgggcc
466861 ggctccgccg gctccggccg gggcggctgc agccggggtc ggcgcggagc caccgcgggc
466921 ggcaagaccg gccagaccgg tgccggccaa acccgccgct gccaggccgg cgtaggagcc
466981 gtccgaactc cccgtcatat acatcggagt cgcgccgggg aacatcgccg caacttggcg
467041 caccgctggc ggaagattcc agctgtgcgg cacggagagt ccgccgatgt tagcggagta
467101 gccggtgagc gcggcgaccg gcggctgtgg cgggctggtg acccgtcctc cgacctcagg
467161 gagatccccg tcacccgcgg ccccagcggg tgtctggtcg gattcggctg ggcaatgcgg
467221 cgccttttgg gcctcgtcga ccacgtcgtg gcggtagatc tcgccgagct gcgccgccga
467281 tacccccaaa ctgccagccg cgacggctac agctgcggct acgagaacgt caagatcctc
467341 gatggggttc ggaatggcgt cgaagggcgg cggtaggaag gactgcaggg ttggtagcag
467401 gctcacgtcg gtcgccgcgg cggccggtac taccgcctga gccgctgtcg cggcggcgtc
467461 actcagcgac ccggccccgc tggtggtcgc cggtggcggg tgaacggcgc aactgggacg
467521 cggcccccga ggcgcccgca tagccgtcca tcgccaagat gtcatgggcc cacatttcgc
467581 cgtagtgcgt ttcactagtc gcgatcgccg gggtgttctg tccaaaaaca ttggtctgga
467641 ccagtgacag cattgtgcgg cggttggccg cgattaccgt cgggggcacg gtcgccgcgt
467701 acgccgactc gtaggcgttc gccgcggcca cggcctgagc cgcggcctgc tcggccgagg
467761 cggcggtggc cctcatccac gcgacatagg ggacggccgc ggccgccatc gacagtgccg
467821 acgggcccag ccagtcatcg ccggtgagcc cggaaatcac cgaggagtag gaagccgccg
467881 tcgcggtcag ttcgttggcc agccgttgcc aggctgcggc cgcttgcatc aggggcctgg
467941 agccgggacc ggaatagatt ctggcggagt tgatttccgg tggtagcgca ccgaaatcca
468001 tgactagccg ctcctcacac cggcagcagc ctcagcgctg cgtggctggg tcgtcacgaa
468061 agacacggat tctcctttgc cgaagctgtc cggtccgcgc agggttcgtc gctgccgcga
468121 gccaggcgac tgggcgcata cctattcggg tggcggcaac catgtcggag ccggatggat
468181 ggctaagcgg tcatcaagtt cggatggctt gggttatcag gtcactcagt tgcccccacc
468241 tcctcatagc aaaagtacac aggcagatgt gagcggagtt gcgaaaatag acaaataatt
468301 gagccgagca acgaccgagc gagagggtga gctggtgatc gacggctgga cggaagaaca
468361 gcacgaaccc accgttaggc atgagcgccc agcagctccc caagacgttc ggcgggtgat
468421 gttgctgggt tcggccgaac ccagccggga gctggcgatc gcgttgcagg gcttgggcgc
468481 ggaggtgatc gccgtcgacg gctatgtcgg cgcgcctgcc caccggatag ccgaccagtc
468541 ggtggtggtc accatgaccg atgctgaaga gctgacggcg gtgatccggc ggctgcaacc
468601 ggatttcttg gtgacggtca ccgccgcggt gtctgtggat gctctcgatg ccgtcgagca
468661 agccgacggc gagtgcactg agctggtgcc gaacgcccgt gccgtccggt gcacggccga
468721 ccgggagggc ctgcgccggc tggccgccga tcagctcggc ctgcccacag ccccgttctg
468781 gttcgtcgga tcccttggcg aacttcaagc ggtggccgtc catgctgggt ttccgttgct
468841 ggtgagcccg gtggcagggg tggctggcca gggtagctcg gtggtcgccg ggcccaacga
468901 ggtcgagccc gcctggcagc gcgcggcagg ccatcaagta cagccgcaga ctgggggagt
468961 gagccctcgg gtgtgcgccg agtcggtggt cgagatcgag tttttggtca ccatgatcgt
469021 tgtgtgcagt cagggcccga acgggccgct catcgagttc tgtgcaccta tcggtcatcg
469081 cgacgccgat gccggtgagt tggaatcctg gcaaccgcag aagctgagca cggcggcgct
469141 ggacgcggcc aagtcgatcg ccgcgcgcat cgtcaaggcg ctcgggggac gcggggtttt
469201 cggcgtcgaa ttgatgatca acggcgatga ggtgtatttc gccgatgtca ccgtgtgtcc
469261 tgccgggagt gcctgggtca ccgtgcgcag ccagcggctt tcggtgttcg aactgcaggc
469321 ccgggcgatc ctgggtctgg cggtggacac cctgatgatc tcgccgggtg ccgcgcgggt
469381 gatcaacccg gaccacacgg caggccgggc agcggtcggc gccgcaccac ctgccgatgc
469441 gctgaccggt gcgctcggtg tgccggaaag cgacgtcgtg atattcggcc gcgggcttgg
469501 ggtggcgctg gccaccgcac ccgaggtggc aatcgcccgc gaacgcgccc gcgaagttgc
469561 atctcggcta aatgtgccag actcacgcga gtgagctacg ccggagatat cacgccactt
469621 caggcctggg agatgctcag cgataatccg cgggcggtcc tggtcgacgt gcgctgcgag
469681 gcggaatggc gcttcgtcgg tgtgcccgac ttgtcgagcc ttggtcgtga agtggtctat
469741 gtcgaatggg cgacgtccga cgggacgcac aacgacaact tcctcgccga gttgcgggac
469801 cgcatcccgg cggacgctga tcagcacgag cggcccgtta ttttcttgtg tcgctccggt
469861 aaccgctcca tcggcgcggc cgaggtcgcg accgaggcgg gcatcacgcc ggcctataac
469921 gtgctggacg gcttcgaagg gcatctcgac gctgagggtc atcgaggcgc aacgggctgg
469981 cgggcggtgg gactgccgtg gagacaggga tgaccgacga gtcttcggtc cgcaccccga
470041 aggcgctgcc cgacggcgtc agccaggcca ccgtcggggt gcgcggcggg atgttgcggt
470101 cggggttcga agagaccgcc gaggcgatgt acctgacgtc cggatatgtc tacggctcgg
470161 cggcggttgc cgagaagtcg ttcgctggcg agctggacca ctatgtgtac tcccgctacg
470221 gcaacccaac ggtgtcggtg ttcgaggagc ggctgcggct gatcgagggt gccccggcgg
470281 cgttcgccac cgccagtggc atggccgcgg tattcacctc gctgggcgcg ctgctgggtg
470341 ccggagaccg actggttgcc gcgcgcagcc tgtttggctc gtgtttcgtg gtgtgcagcg
470401 agatcctgcc gcgctggggg gtgcagaccg tcttcgtcga cggtgacgac ctctcgcaat
470461 gggagcgggc gctttcggta cccacgcagg ccgtgttctt cgagacgccg tccaatccca
470521 tgcagtcgct ggtggatatc gctgcggtga ccgagctggc acatgccgcg ggtgcaaaag
470581 tggtgctgga caacgtattt gccacaccgc tactgcagca gggctttccg ctgggggtcg
470641 acgtggtggt gtactcgggc accaagcaca tcgacggtca gggtcgggtg ctgggcgggg
470701 ccatactcgg tgaccgggag tacatcgacg gtccggtgca aaagctgatg cgccacaccg
470761 gtccggcgat gagtgcgttc aacgcctggg tactgttgaa aggccttgag acgctggcta
470821 ttcgggtgca acacagcaat gcctcggcgc agcggatcgc ggagttcctc aacggccatc
470881 cctcggttcg gtgggtgcgt tacccgtacc tgccgtcgca cccacaatat gacctggcca
470941 agcgtcagat gtccggtggc ggaaccgtcg ttaccttcgc actcgactgc ccggaggatg
471001 ttgccaaaca gcgggccttc gaggtgctcg acaagatgcg gctgatcgac atctccaaca
471061 acctcggcga cgccaaatcg cttgtcaccc accccgccac cacgacgcac cgggcgatgg
471121 gcccggaggg ccgggccgcg atcgggctcg gtgacggtgt ggtccgcatc tcggttgggt
471181 tggaagacac cgacgacctg attgccgata tcgatcgggc gttgagctaa cccgctgcct
471241 cttgctcggc gtgctcggcc tgttcggcgg ctgccagcgc tccttgtgcc tgctgttcca
471301 tcaaggtcat cactaacctg gcgtagatca tctggctggt gatggccatc tggccgcggg
471361 cgcggcccat gaaggagatc ccccaggcga acagggctgc gatgcggttc cgatagccga
471421 ccaggtagac caggtgcagc accagccacg ccagccaggc gaagtacccg gcaaactcca
471481 gcttgccgac ctgcgcgacg gcgctgtggc gggagatcgt cgccatgctg cccttgttga
471541 agtaatggaa cggcttgcga ttggctgggt cgtcattgcc cttgaccatg tgtttgatca
471601 ccgtggtggc gtatcgggcc ccctggatcg cgccctgagc caccccgggt acgccgggca
471661 cgaacatcag atcgccgact acgaagacgt tcggatgtcc cttgacggtg agatcgggtt
471721 ccacgatcac ccttccggcc cggtcgattt cggttccgtc ggatccctcg gcgatcatct
471781 tgcccagcgg gctggccgcc acgccggccg cccaaacctt gcacgcgcat tcgatgcggc
471841 gttcgccgcc gtccttttcc ttgatggtga tgcctttgta gtcgaccgcg gtcaccatcg
471901 cgttgagttg aacctcgacg tccatctttt ccagccgccg ttgtgccttg agacccagct
471961 ttggacccat cggcggcaac accgcgggtg cggcgtcgag caggatcacc cggcactcac
472021 tgggcgtgat ggtcctaaac gcgcctgcca gggtgcgctc ggcgagctcg acgatctgcc
472081 cagccacctc gacgccggtc ggcccagcgc cgacgacgac gaacgtcagg cgccgctccc
472141 gttcggcatg gtcggtgctg acctcggcgg cctcgaacgc gcccaggatg cggccgcgca
472201 gctccagcgc gtcgtcgatg gtcttcattc cgggcgcgaa ggtggcgaat tcgtcgttgc
472261 cgaagtagga ctgctgtgcg ccggcggcca cgatgaggct gtcgtacggc gtcaccgtgg
472321 tcatgtccat caatttcgac gtgaccgtct gcgctttcag gtcgatcgcg ttgacctcgc
472381 ccagcaacac ccggacgttc ttttgccggc gcaggatcag ccgggtggtc ggggcaatgt
472441 cgccctcgga caagatcccg gtggccactt gatacagcag cggctggaac aggtgggtcg
472501 ttgtcttgga gatcagcgtg atgtcgacat ccgcccgttt aagcgccttg gccgcattca
472561 ggccgccgaa tccactaccg atgatgacca cgcgatggcg cccgccgacg gccgagggtt
472621 caccagatga gagcgtcatg gtcctccttc agtctggtcg ctgtggcgca gctacacagt
472681 acgactcccg tcatgccaac ggcgtaactt tttgtgggcc ttgtgggcct tgtgggcctt
472741 gtgggccttt gtcgggccgc cttcggatcg gacgctcggg atggctgttg ggcgctgcgc
472801 aatcccgcgc ttcgatcagg cagcgtccgg cagtgccatc aatggcggcc aggtacacct
472861 ctccgacggc tcgacatcgc cggcccggca gttacctgca ccatggccgg gcgatgcggg
472921 agcggctgcc gaaggtcggg caggtgtttg ctgccgggga aatcgactac cacatgtttc
472981 agacgttggt gtatcgcacc gatttgatca ccgacccgca ggtgttggcg cgggtggatg
473041 ccgagctggc gctgcgggtg cggggctggc cgtcgatgac ccggggcagc tggccgccgc
473101 gatagatcgg atcgtggcgg tggccgaccc cgatgcggtg cgccaggtgc gggagcgggc
473161 ccgcgatcgg gaggtgtcga tctggaattc cgcggacggc atgggcgagg tgtacgccca
473221 gttgtatgcc accgacgccc aagccctgga tgcgcggctg aacgccttgg tggccacggt
473281 gtgtgccggt gatccgcgca gcacagatca gcgccgcgcc gacgcgctgg gcgcgttggc
473341 ggccggggcg gatcggctgg cctgccgctg cgacaatccc gactgtgccg ccgaggggcg
473401 cccggtgtcg gcggtggtga ttcatgtggt ggccgagcag gccagcgtca agggccacgg
473461 ccaggcgccg gcagcgttgc tgggcggcga cgggctgatc ccggccgagc tggtggccga
473521 gttggccaag accgccgggc tgcagccgat cccggtcccg gccgggaccg agccgggtta
473581 tcggccctcg gtgaagctgg cggcgtttgt gcgggcccgg gatctgacct gtcgggcgcc
473641 cggttgcgac cgcccggcca cccagtgcga cctggatcac accatcgcgt tcgccgacgg
473701 tggggccacc cacgcggcca acctcaaatg cctgtgccgt cttcatcatt tgctggccac
473761 cttctgtggc tggcgcgccc agcaactgcc cgacggcacg gtgatttgga cgctgccggg
473821 taaccagacc tacgtcacca ccccgggcag cgcgctgctg ttcccggcgc tgtgcacccc
473881 caccggtgac ccgcccgcac ccgagccggc ccgcgccgac cgccgcgggc agcgcaccgc
473941 gatgatgccg cgccgggcca gcacccgcac ccaaaaccgc gcccattgca tcgccgccga
474001 acgccaccgc aaccaccaag cccgccggat tgcccaagcg gccgtcatcg ccaccgagac
474061 ccacggccca ccacccgatc ccgacgacga cccgccgcct ttttgatgaa gtgagtccga
474121 atcatctcga cgtggacggg tgcggcgtcg ggtggtcgcc ggttggcgca gaccctccag
474181 aggggaggat gaggagctcg gcacctgcgt cggcggccct gagataggcc agcaggcggt
474241 ggccgaagtc gctgacgtcg tggataagga tgtggccgct ttcttctgcc ggagtcccgg
474301 tgccgttgcc gtgccaaacg gttgttgtcg cgatcgcgac gccggtttga atgagggccg
474361 ctagcaccgg cacgggctcg accttactcg ccgccctcat cacctcgcgt cgctggatct
474421 cgtcctggtc cggtgaggac ttggcggctt tggccagccg aacgagtgca tggatatgca
474481 cgggctcaag ttgggaaagc gtggccacga tgagtgatgc cggctcgacc ttctggtcat
474541 cctcgagcgc ggcggcggca gcttgcgcga ggagccggcg cttggcctcc atactggtgc
474601 gagtggcggc ctcgatcgcc tggctgagaa gcggctcgag ttcgggattt ttgtcaatgc
474661 ggctcaacac ggtgtccgcg ccgccgacgc tctcgcatat ctcgcgcgtg gttgtctcgg
474721 cgcggtgccg ggtgcgttcc tcgatggcgt cgaacacggt ttgtagcggg ccgccgacca
474781 tcgggatggc ggataggccg gcgctgatca cgacagcgaa gacaggtctg ggctcagtca
474841 tagctcgaac agtagaggcc gtcgcggcaa ggacggccga cggcgtgttt tcggcgttgc
474901 ggggtggtcg ccggacacga ggaggcagac cgaggctcga tggattggat gccgctcggc
474961 gactacgaga ctttccggca ttggtcgggg aagccccgcg catgggggcc gcaagagtcg
475021 gggtggcgcg cgtggttcgg cgggaagata gtcgatgggc tctgcgaggt actcgacgag
475081 cacctcgcgg tgcggcgtcg tggtgttcca gccgcgatcg gctgcgtgcc ctggctgagt
475141 agcgaggcgg tcgccgagac gctgctcgca ttgagcgtct tttgcgtggt gatcgacaag
475201 ggaacctcgt tcccgtcgcg actgcgtaac cctgacaaag ggtttcccaa cgtcgcccta
475261 ttgcggcttc gcgacatggc gccctccgag catggctcac gctgctcctc ggcccgtggt
475321 cgtctatgcc tgagcatgag ctaggtccgg tgcgggcgct cggctggcta cgagaggacc
475381 gcaagccgct gctgaatgcc aaattgctcg tgctcggtca tctggctttg aacgtctacg
475441 accccgataa cggttacggc gaagaggtgt tggactttga gccgcggacg gtgtggtggg
475501 gatcggccaa ttggaccgtg cgggccgggt cacacttgga agttggcttt gcatgcgacg
475561 acccaaccct cgtcgaagaa gctacagcgt ttgtcgctga cgtgatcgcg ttctccgaac
475621 cgatcgacac gacctgtgcc ggtcccgaac cgaacctcgt gcaggtggag ttcgacgacg
475681 ccgcgatggc tgaggcgatg gaggagatgg ccgagcccga tgatgacggg gaggattggt
475741 agcgatgctg cttgatgaac ccaaaggtcg tcacgggcac gctcaaaacg ttcttcgtgt
475801 aatcggtgcc atcatttgct ggccaccttc tggggctggc gcgcccagca actgcccgac
475861 ggcaccgtga tttggacgct gccgggtgac cagacctatg tcaccacccc gggcagcgcg
475921 ctgctgttcc cggcgctgtg cacccccacc ggtgacccac ctcgacccga cccggcccgc
475981 gccgaccgcc gcgggcagcg caccgcgatg atgccgcgcc gggccagcac ccgagcgcaa
476041 aaccgcgccc actacatcgc cgccgaacgc caccgcaacc accaagcccg ccggattgcc
476101 cacgtggtca cccaaaccgc cacaaccgcc cccgagacta acggcccacc acccgatccc
476161 gacgacgacc cgccgccctt ctaaccggta ggcgcctgcc caaaacacgg gtattgggta
476221 aaggcacggg gtcctgatgt tgttgtattt caatgcgatt cagctaaggc ccggagccca
476281 tggctcgtcc ggatggtcgg ttggggtgat gtgtatgccc ctcctgctcc atcccgtttc
476341 cttgtatcct caagtttgtc gtttggcgct gttgcgacag gaaggcgtcg atcatgcacg
476401 cactgaggtt ggtcggcttg gcgatattga cggcgatcgc tccaatcgcg gtcctcatcg
476461 gaagtagccc agcgcatgcc gataccgata ttggtcaacc gtgctcgccg gaaggcgcga
476521 aactctgggg gaaccccggc ccgatatatt gcgagcgcac ggcggacggg caactgcaat
476581 gggtatcaat tcctgcttgg gcattgtgtg tggcgttctg cgaccggcct ggcgggccat
476641 aggggcccac cagcggaccc ccacggtccg ccggcctgct agcccggcca tgagctcgcg
476701 gtggttcggt agttcgcgtt gggcgcactg cagaagtccg aggccgtgcc ggccagcaag
476761 acgaaatagc cctcttcgcc gcggcgggtg tcggcgaacg gcgggtaggt ccaaccgttg
476821 ttgcacatcg aagtcggcgt gcccgccgtg gccttgcgcc aaccggactt gacgcaggcc
476881 ttgagggcgt cgacgtcgga aacggtgctc ttggcgacga ccagcatcgc gcctccccat
476941 tgcccgtcgg ttcgccggta ggcgcgcgcc ccgaagccgg cccccgagcc ggctgtgttc
477001 tgttggcagc ccaacacccg ctgcagcggc aagaacaccg acgccacatc gcggtccgcg
477061 acagcggctg cggccgtgat gaattgagcc gcgtccgagc cgtcaacctc ctggacggtg
477121 ggatctccga agctaaacag ctgctgtgag atccgctgtc gcagcgcggc gtcaccgtcg
477181 ccgatgaccg gtccgctgcc gctggatgtc atcgggggca gcgcgccggt gggttccgcg
477241 cccgcggtgg gcgcggcggc cagcacggcc agggacaaac cgcacgcggc gacaccgaca
477301 acgcgggcaa tgactcccat ggctacctac ctccccggcg gcatgggtgg ggcgtcgttc
477361 ggtgctacct cggcaccgat cttgcgaaat agtatgtcgg cctggttgcg gtagttgccc
477421 tggtcatcga aggcctcggg ggcgtaggtg actgcgaccg ccaccgcgac ccgttgcgac
477481 ggcagatagg cctccaccgc ggcgtaaccg gcgaacatgg gattttgcag cagccaatgg
477541 ccggatatga cgatcccgag accatagctg tagccgtcgt tctgctcgaa gcaggtgggg
477601 cagcccggct gggcgcgggt cttgccgcgc agctcggtcg acaccatctt cttgtacgaa
477661 tccgccgaga gcagcctgcc cgacccgatc cccaccgcgg tggcctccat gtcgtagatg
477721 gtggtggttt ggatggcgcc gtgggtgatg gtccacgacg gattccagaa ggtcgattcc
477781 tcgtaaaacg gcacgccggc aggaattttc aaggccgctc ggcgctcgga ggtgaatgca
477841 tgcaaggcgg gctcggggat ggcgggggta tcggagttgg cggtggccgt gaggcccagg
477901 ggggaaagga ccttgcgctg cagcagggtt ggcatgtctt ggccggcggc cttctccaac
477961 gccagcccca gcaagaggta attggtgtgc gcgtagttcc agttggtgcc cgggtcgtaa
478021 agcagtggcc gtgaagagat ttgatcgagt aactcttgtg ttgtccactg ccggaacgga
478081 ttagcgtaaa gctcggcatc aaacgcctcg ttgccgagga cgtagtcggg gtagccggat
478141 gtcatctgcg ctagttgacc cagcgtgacc cggtcggcgt gcggaaagtc gggaagccac
478201 ctggacagct tgtcgtccag gcgcagcttt ttttcgtcga ccagtttgag caacagcgtc
478261 gcgacatagg agattgcgac cgcgccgttg cgaaagtgca tggcggtggt ggccggcacg
478321 ccggtcatcg agtcgccgac ggcccgcgtc acgacctcct tgccggccac ggtgacccgg
478381 accagcaccg ccttcagatg cgcttgcgtc atgaagtcac gcacaatccg gatgaccgcg
478441 tcggccttgg ccccgttgtt ggtcggcgac gaagccggcc cggtgcgggg tggggcgcag
478501 ccggccagca gcccgagagc caggaccgaa cacccgaggc gccgcaagac gggcatgcga
478561 cggtcctacc ggaaggcggc caagcccgtg aaggcctgac cgagcaccag ctgatgcatc
478621 tcgggcgtgc cctcgtaggt gagcaccgac tccaggttga ccatgtgccg gatgaccggg
478681 tactccagcg atatcccgtt gccgcccagt attgttcgag cggtccggca gattttgagc
478741 gcttcccggg tgttgttgag cttgccgaag ctgacctgat cggggcgcag gcccaccctg
478801 tctttgaggc gccccagatg caacgacagc agctgaccct tgtgcagttc cacggccatg
478861 tcgacgagct tggcctgggt cagctggaag ccggcgatcg gacgtccgaa ctgggtgcgc
478921 tgtctcgcgt agtcgagcgc gcactgccag gccgacctgg ccgcgcccat cgctccccag
478981 acgatcccgt agcgcgcctc cgacaggcat gccagcggcg ccctgaggcc ggtcgcgccg
479041 ggcagcatgg cgtcggcggg cagccggaca ttgtcgagca ccagctcgct ggtgatcgac
479101 gcccgcagcg acagcttgtg accgatggtg ttggcggtga aacccggggt gtcggtgggc
479161 acgatgaatc cgcggattcc gtcgtcggtg gcggcccaca cgatcgccac gtcggcgacc
479221 gagccgttgg tgatccacat cttgcccccg gtgatcaccc agtccggacc atcgcgtcgc
479281 gcccgggttt tcatcgcggc cgggtcggag ccgacgtcgg gctcggtgag cccgaagcag
479341 ccgagcaggt caccggtggc catgccgggc agccactgcc gcttttgctc gtcggagcca
479401 aagctcgcga tggcgaacat cgccagcgaa ccctgtaccg acaccagcga ccggatgccg
479461 gagtcggcgg cctccagctc ccggcaggcc aggccatagt gcaccgccga cgcgccgcca
479521 cagccgtggc cgtgcagctg cattcccagc agtccgagtt cgccgaactg tttggccaaa
479581 tcgcgcgcga ccggtaggtc gccgtcctcg aaccacgccg cgacgtgcgg ggtgacgtgt
479641 tcggcgcaga accgcctgac ggtgtcgcgg acggcgatct cgtcgctgga tagcgacgcg
479701 tccagtccca gcgggtcgtc gcggtcaagg gcgggtggtg tcggggtgct catcactcaa
479761 tactgccccg gcccggtagc ctcgcggcat gcgaccacgg cgcgcgctgg cggggctggc
479821 cgccgacgtc gtcgccgtgc tggtgttctg cgcggtggga cgtcgcagcc acgccgaagg
479881 actgagcgtc accggcctgg cggctacggc atggccattt ctcaccggca ctggtatcgg
479941 ttgggtgctg gctcgcggct ggcggcggcc gaccgccctc gcccccacgg gggtgatcgt
480001 gtggctgtgc accatcgtgg tcggcatggt gttacgcaag gtcagttcgg cgggtgtggc
480061 cgcgagtttc gtcgtggtcg cgtccgcggt caccgcggtg ctgctgctgg gttggagagc
480121 cgccgttgcg ctgatggcac cgcaccgcgc ggacggctga gaaggccaaa tgtcgtcggg
480181 gtgttcgccg accccgggat ttccgacgtc cgcctccgtg ccctcgaagt ctcagtaccg
480241 agccagattt cacggtcgag accccaacca acaggtcagc gcggtgccac cgcgatcgtg
480301 atgttggcgc aggtatgggc cgcgacctgt cgagctacga cccgggccgt gccgctactg
480361 cagcagcgct gcgcgttccg cactgagcgc agtggtgcga cgaggcccga gcacctgggg
480421 ttgtcgggct agccgatcca cccgacgtgg ccaccagaac cagcggccga gcagagttgc
480481 cagcgcaggc gtcatgtaag accggacaac gagggtgtcg aacagcaatc cgatcatgat
480541 cgtggtgccg atttggccga cgacgcgtag atcgctggcc accatcgagc ccatggtgaa
480601 ggcaaacacc agtccggcga tggtgaccac tcggccggtg ccggccatgg ctcggatcat
480661 gccggttttg aggccggccc cgatttcttc ttggaatcgg gctatcaaga gcaggttgta
480721 gtcggatccg acggccaaca tgacaatgat ggccatgggc agcacgagcc agtgcagtgg
480781 catatgcagg atgtgctgcc agatgaggac cgacaatccg aaggctgagc ccagcgaaag
480841 ggcgaccgtg ccgacgatga cggcggatgc gaccacgctt ctggtgatgc cgagcatgat
480901 gatgaagatc aggcaaagcg acgccacgac ggcgatcatg acgtcataca gggtgccctc
480961 gtggatgtct ttgtaggtgg atgaggtgcc cgccagatag atgctggcag cctgtagcgg
481021 ggttcctttc acggcttcgt cggcggcctg catgatgggg tcgatgtgtg agatgccttc
481081 agcgctcgcg ggatcacccc gatgggtgat gacgaatcga gcgcaggtgc catcggggga
481141 taggaagagt ttcagacccc gctggaagtc ggggttttgg aaggcctccg gtggaaggta
481201 gaacgagtcg tcgttgttgg cggcgtcgaa tgttcgaccc atgacggtgg cgttgcgggt
481261 catgtcttcc atttgagtga ccagtccgga gaacgcgctg gtcagtgttt gggcaaggtc
481321 tttgacggtt tgcatggtgg cgatcgtggg gtccagttgg gcgagtagtt gccgctgtgt
481381 ggtgtccatg cgttcggtgt cgtcggtgag gttggcaagg tcctcggtga gcttgtcgac
481441 gttatccatg ctgttcaaca aggagcgcat cgaccagcag atgggaatgt cgaagcagtg
481501 gcgctcccag tacgtgaaac ttctgagggg gcgccagaag tcgtcgaaat cggcgattcg
481561 atcgcgtagt tcgttggcgt tgtctcgcat ctgcctggta tgagcgttca tatcatgggt
481621 ggcatcggtt agctgtcgcg tcagctcctg ggttcgctgg gtgatgtcga tcatgcgttg
481681 cagttgatcg gtaagggtgg atagatcagc cacgcggtcc ttgaggttct gcaggttttc
481741 gatggtcatc gtgctttgca tgccgagctg aaacgggatc gacgagtggt cgatcggagc
481801 ccccaacggt ctggtaatgc tttgcacccg cgcgatcccc ggcgtatgga agacggtttt
481861 ggcgatcctg tccaggatga gcatgtcggt cgggttacgc aggtcgtgat cggcctcgac
481921 catcaggacc tccggttcca tgcgggcttg cggaaagtga cggtctgatg cgaggtaacc
481981 gatgttggat ggcgccgcgc tggggatgta gtagcgctcg ttgtagttgg tctggtattt
482041 cggcaaggcg agcagtccga tcagcgctat cagcagggtg gcggccaaga cggggccggg
482101 ccatcgcacg acgaccgtgc cgatccggcg ccaacgccgt ttcgttgtcg ctcgtttggg
482161 gtcgaatagc ccgaatcggc tggcaacggc gatgatcgcg ggcgccagcg tcagagacgc
482221 caacatcacc gtgaccaaac cgatcgcgca tggcgatgcg agggtattga agtagggtag
482281 ccgggtaaag ccgaggcagt acatggcgcc ggcgacggtg aggccagatg ccaggaccac
482341 gtgtgccgtc ccaccaaaca tggtgtagta agcggcttct cggttctggc cagtcgcacg
482401 tgcctcttga tagcgtccga cgagaaagat gatgtagtcc gtcgaagccg cgatcgtgag
482461 cgccaccaac acgttgacag tgaatgtaga caggcccatg aggtcgttga cggcaaaagt
482521 ggagatgatg ccgcggaccg ccagcagctc gagcccgacc gtcagcagca tgatcagagc
482581 agcagaaagc gagcggtagg cgatgaacaa catgatcgcg atcaccgcaa tgctgatgcc
482641 ggtaatcgtg tgaaggctgc ggtcgccgta tacaactcga tcggcgccga gtggacccgg
482701 gcctgtcacg taagccttga tccccggcgg cggtggcacg ctgtccacga tgcgttgcac
482761 ggcggcgaca gactcgttgg cctgcgagcc gccctgatca ccagtgaggt tcagctggac
482821 atatgctgcc ttgccgtcag cgctctgcga tcccgccgcg gtcagcggat cgccccagaa
482881 gttctcaatg tgttggacgt gggtggtgtc ttgtgacagc ttggtcacta gcacgtcata
482941 gaagcggtgc gcctcatcac ccagcttctc ttggccctcc agcagcacca ttgcagtggt
483001 gtcagaatcg aattgctgaa agtccttgcc gatgcgcttc atggcgatca gtgacggagc
483061 atcgtggggg cctaacgcca ccgaatgtgt cctagcgacc gactgtagct gcggcgcaac
483121 gacgttcacc acaatagtca gcgccaccca gaacagaatg atgggtagcg acaacgcatg
483181 gatcgtccgg gcggcggccg acaggtgccc ggctagacgt tggctcctca cgcggatttc
483241 accaggcaac tggtgtgcgc gtggtaagca ttcacaatgc gctcctcgcg gatcacctcg
483301 ttgacagtga tgcgacagcc caggcttgca ccgtcaccgc gggcaaccac gttggcgact
483361 acggcggtca aggtggtcac gatggtaaat gaccacggga ccgcggcatt gacgacctca
483421 tgcggctggg catcggcatc caggtaattg atgctggcga ccgtccctgg cgggccgaag
483481 acctcgtaga gaacatgctt cgggtaaaac gcgatgatcg ggtcgaggtt gccggtgtcg
483541 ggcgcatgtt gatgtgagcc aaacaccgag tgcagccgcg agaccgtcac ggccgcgaca
483601 gccacaacga tgactatcac catcgggatc cagaagcgtt tggcaacgcc gaacatttac
483661 cttcctgatt ccatcgcttc aacaagccgc cgcgtgagga cgaaccctac cggggagacg
483721 ccactcgttg gggcagtttt gtacactccg tttacatcgt ttacggcgag gtcaaaaaat
483781 ttcggttaat cgtacaggct gccgctcggt catctatagt catcgatcca gagccgcttc
483841 gaccagcctg tggtcgaagc ggatcagttg aaccggagga gtggaaacat gagcggcccg
483901 acgggaaatt cgatgcccag acagctcggc ggcctggtgg ccaggatcgt taccgggtaa
483961 gggatcgcca ctcccaatgt ctgttatatc cacgttgcgc gaccgtgcga ccacgactcc
484021 aagcgacgaa gcctttgtgt tcatggatta cgacacaaaa accggcgacc aaattgaccg
484081 aatgacgtgg agtcaattat attctcgcgt caccgccgtg tctgcgtatc taataagtta
484141 tggccggcat gctgaccgac gaaggaccgc agcgatatca gctccgcaag gtctggacta
484201 tgttgcagga tttctaggag cactgtgcgc cggatggacg ccggttccgt taccagaacc
484261 gctgggcagc ctacgcgata agcggactgg actggctgta ctcgactgtg ccgccgacgt
484321 cgtgctgacg acgtcgcaag ccgaaacgcg ggtcagggcc acgatagcta cacatggggc
484381 gtctgtaact acgccggtca tagcgttgga tacattggac gagccatccg gagataactg
484441 tgatctcgat tctcaactat cagactggag ttcgtatttg cagtatactt cgggttcaac
484501 ggccaacccc cgtggtgtgg ttttatccat gcgtaacgtt acggaaaatg tcgaccaaat
484561 tatccgtaac tattttcgcc atgagggcgg cgcgccgagg ttgcccagct cggtcgtttc
484621 gtggttgccg ctttaccatg acatgggttt aatggttggc ctctttattc cgttgtttgt
484681 cggatgtccg gttatcctga cgagcccaga ggcatttatc cgtaagcctg ccagatggat
484741 gcaactgctt gctaaacacc aggcgccatt ttcggccgcg ccgaacttcg cattcgattt
484801 ggccgtcgct aaaacttccg aagaggacat ggcggggctg gatttaggcc acgtaaatac
484861 aataatcaac ggcgcggagc aggtacagcc aaatacaata accaaattcc tccgccggtt
484921 ccgtccctac aatttgatgc ccgcagcggt caagccatca tacgggatgg ctgaagcggt
484981 ggtttacctg gcgacgacga aggcgggatc acctccaacg tcaaccgagt tcgatgctga
485041 tagcttggct cgaggccacg cggagctaag tactttcgaa actgagcgtg caacgcgttt
485101 aatacgctac cacagcgacg acaaggaacc gttgcttcgg attgtcgatc cggactcgaa
485161 tatcgagctc ggaccgggac gtatcggcga gatttggatt cacggtaaga atgtgtctac
485221 cggatatcac aatgcagacg acgcgctcaa tcgagataag ttccaggcca gcatccggga
485281 ggcctctgcg ggaacgccaa ggtcgccgtg gcttcgcacg ggagacttgg gattcatagt
485341 aggagatgag ttctacatcg tcggccgtat gaaagatctc attatccaag acggtgtaaa
485401 ccattatccc gatgatatcg aaactacggt caaggagttt accggtggcc gggtcgcggc
485461 attttcagta tccgacgacg gggtggagca tttggtcatt gcggccgagg taaggactga
485521 gcatgggccc gataaagtga ctattatgga tttctcgacg atcaaaaggc tggtcgtatc
485581 ggcgttgtcg aaattacatg gcctgcatgt aacagatttt cttctggtac cgcccggggc
485641 gctaccgaag accaccagcg gaaagattag ccgggcggca tgcgcaaagc agtacggagc
485701 aaataagttg caacgagtag caacgttccc atgacagacg gttcggtcac tgcggataag
485761 cttcaaaaat ggtttcgaga gtacttgtcc acgcatatcg agtgtcatcc aaatgaggtc
485821 agcctagacg ttccgattag agatttaggt ttgaaatcga ttgatgtctt agcgattccc
485881 ggcgacctcg gtgacagatt tgggttttgt attcccgatt tggccgtttg ggataatcct
485941 agcgctaatg atttgattga tagtctgttg aaccagcgta gtgctgactc gttaagagag
486001 agtcatggac acgccgacag gaacacgcag ggtcggggca gcataaacga gccggttgcg
486061 gtcatcggag tgggctgtcg atttccggga gatattgacg gcccggaacg gctatgggac
486121 tttctgaccg agaagaagtg tgcgataaca gcgtatccag atcgtgggtt cacgaatgct
486181 ggaactttcg cggagtccgg aggcttttta aaggatgtcg cgggtttcga taatagattt
486241 tttgatatcc cgccggacga ggctctgcga atggatccgc aacaacggtt gttactggag
486301 gtctcttggg aagcgttaga gcatgcagga attattcctg agtcattaag actttcacgt
486361 acgggcgtat tcgttggggt gtcgtcaact gactacgtcc ggcttgtgtc agctagcgct
486421 cagcaaaagt ctactatttg ggataacacc ggcggttctt cgagtattat tgccaataga
486481 atctcatact ttctcgatat tcagggtccg tccattgtca ttgacacggc atgctcgtca
486541 tccctggtcg ccgtgcatct agcctgtcga agtctcagta cctgggactg cgatatcgca
486601 cttgtcggtg ggacgaatgt tcttatttca ccagaaccat ggggtgggtt tagggaagcg
486661 ggcatcttgt cgcagacagg ctgctgtcac gcgttcgata aatccgccga cgggatggta
486721 cgcggtgagg gatgcggagt tatcgtgctg cagcgcctca gtgatgcacg ccttgagggc
486781 cggcggatat tagcgattct gacgggttca gcggtcaatc aggacggtaa gtccaacggt
486841 attatggcgc caaatcctag tgcgcaaatt ggtgttcttg aaaatgcatg caagagcgct
486901 cgcgtcgatc cgctggaaat cggctacgtc gaggcccacg ggaccggaac gtcgttaggg
486961 gataggatcg aggcgcacgc cttaggcatg gtctttggtc gcaagagacc gggatctggg
487021 cccctgatga tcgggagcat caagccgaat atcggccatc tggaaggtgc ggctggcatc
487081 gccggattga tcaaggcggt gttgatggtt gagcgtggct cgctgcttcc gagcgggggg
487141 tttacggagc caaatccagc tatcccattc acggaattgg gcctgagagt tgtagacgaa
487201 cttcaggagt ggccggtggt ggcgggtcgg ccgcgccggg ctggggtgtc atcgttcggc
487261 tttggcggca ccaatgcgca tgtgattgtc gaggaagctg gttcggttgg ggcggacacg
487321 gtttcgggcc gcgcggatgt tggcggttcc ggtggtgggg tggtggcgtg ggtgatttcg
487381 gggaagacgg cttcggcgtt ggctgctcag gcgggtcggt tggggcggta tgtgcgggct
487441 cggccggcgc ttgatgttgt tgatgtgggg tattcgttgg tgagcacgcg gtcggtgttt
487501 gatcatcggg cggtggtggt cggccagact cgcgatgagt tgctggctgg gttggctggg
487561 gtggttgctg gtcggccgga ggctggggtg gtctgcggtg ttggcaagcc ggcgggcaag
487621 acggcttttg tgtttgccgg tcagggctcg cagtggctgg gtatgggtag cgagctttat
487681 gctgcctacc cggttttcgc cgaggccctc gatgctgtgg tggacgagtt ggaccggcac
487741 ctgcggtatc cgctgcgcga tgtgatctgg gggcacgacc aagatctgtt gaataccacc
487801 gaattcgccc agccggcgct gtttgcggtg gaggtggcgc tgtatcggct gctcatgtcg
487861 tggggggtgc ggccgggttt ggtgctgggt cattcggtgg gcgagttggc cgcggcgcac
487921 gtcgccgggg cgctgtgttt gccggatgcg gcgatgctgg tggccgcgcg tggacggttg
487981 atgcaggcgt tgcccgccgg cggcgccatg tttgcggtgc aggcccgtga agacgaggta
488041 gcgccgatgc tggggcacga tgtgagcatc gcggcggtca atggtccggc ttcggtggtg
488101 atctctggtg cccacgatgc ggtgagcgcg atcgctgatc ggctgcgcgg ccagggccgt
488161 cgggtccacc ggttggcggt ctcgcatgcc tttcactcgg cgttgatgga gccgatgatc
488221 gctgagttca cagccgttgc ggccgaactg tctgtgggct tgcccacgat cccggtcatt
488281 tccaatgtga ccgggcagtt ggtggccgac gacttcgcct cagctgatta ctgggcccgg
488341 catatccggg cggtggtgcg gtttggcgac agtgttcgta gtgcccactg cgccggtgcc
488401 agtcgtttca tcgaagtcgg gcccggtggc ggcttgacgt cgttgatcga ggcatcgctg
488461 gccgacgcgc agatcgtgtc ggtgcccacg ctgcgcaaag atcggcccga accggtcagt
488521 gtgatgacgg cggcggccca gggcttcgtc tcggggatgg gcctggattg ggcctcggtg
488581 ttttccgggt accggcccaa gcgggtggag ttgccgacgt atgccttcca gcatcaaaag
488641 ttctggctcg caccagcccc atcggtcagc gaccccaccg ccgccggcca gatcggggct
488701 agcgatggtg gtgctgaact cttggcgtcc tccgggtttg ccgcccggct ggccggtcgg
488761 tcggccgacg agcaactcgc cgcagcgatc gaggtggtat gtgagcatgc cgcagcggtg
488821 ctggggcgcg acggcgctgc cggactcgac gctggccagg cgtttgccga ttcgggattt
488881 aattccttga gtgccgtgga gctacgtaac cgcttaacag ccgtcaccgc agtaacgctg
488941 ccggccaccg cgatcttcga tcaccccacc ccgaccgaac tagcccagta tctgatcacc
489001 caaatagacg gtcacggcag ctccgccgcc gcagcggcaa acccggcgga gcgaatcgat
489061 gcgctcaccg atctttttct acaagcttgc gatgcgggtc gggatgccga tggttggaag
489121 atggtcgccc tggcgtcgaa tacgcgcgag cgcatgagct caccggttcg gaacaacgta
489181 tcgaagaacg tcgcactgct ggcagatggt atctccgatg tggttgtaat ttgtatccca
489241 actctaactg tgctatcgga tcagcgtgaa tatcgagata ttgcgaatgc gatgacaggc
489301 cgccattcgg tttattcgct tacgcttccc gggttcgatt cgtctgatgc actgccgcaa
489361 aacgcggata tgattgttga aaccgtatct aacgcaatta ttgatgtggt aggcggcagc
489421 tgccgttttg tgctgtcggg ctattcatcg ggtggggtgt tggcctatgc cctctgctcc
489481 catctgtcgg tcaagcacca gcggaatccc ctcggagtcg cactcatcga tacatatctg
489541 cctagtcaga tcgccaatcc ttcaatgaat gaagggttca gccccaacga tactgggaag
489601 ggcctttccc gtgaagtaat tcgagtggcc agaatgttga atcggttaac tgccacccga
489661 ctcaccgcgg cagccaccta tgctgcaatc tttcaggcct gggaaccagg tagatcaatg
489721 gctccggttc ttaacatcgt ggcgaaggac cgaatagcta ccgtcgaaaa tttacgcgaa
489781 gaacgaatca accggtggcg aactgctgct gcagaggcgg cctattctgt agccgaagta
489841 cccggggatc atttcggaat gatgagcacc tcgagtgagg caatagctac cgaaatacat
489901 gattggattt ctgggctcgt tcgagggcct catcggtagc tttgcgaatc ggcccgtgcc
489961 acagctcgcc gtgaccaggt gccaggatgt tggtctctag caaagccagc gcagccaggc
490021 tgcggatact gttctgctgg ctgtggctga acaccgcggg cagtagctgt ggcccgcggt
490081 gacgcaacat cggatgacca gtgatcagcg catcgccgct ggccagcaca ccgtcgacga
490141 catacgagca gtgaccgctg gtgtgtcccg gggtgaaaat cgccatcggt tgacccggca
490201 gcccggcggc cgcttcggcg gtcagcggct gggcggtcgg aatgccgtcg ccggtcaggc
490261 cgccgcggcg aagcaagtga ataccccaga ccgccacacg gggccgccag ctgcgcagcg
490321 caacatcgaa aaccgaggca ttctcccggt attcccgctt ggcgtgacct acctcctcgg
490381 cgtggcagta caccggcgtg ctgtgctcac gagcaaacca gattgccgag cccaggtggt
490441 cgatgtgcgc gtgggtgagc acgatggcgc gcacgtcacc cggtgtgtag cccagtttgt
490501 tcagcgaggc cagcacctcc gcacggtcgc cgggatagcc ggcgtcgatc agcagcacgc
490561 cggtgtcgtc ggtgactagc acccagttga ccgcgtggcc gcgagcgagg tgaaccttgt
490621 cggtgatctg aacaagctcc gccatgcccg cgagtctagg agcgagcgcg agcgcggcaa
490681 gccgggtgcc gcgggtcgcg accatgggat atggagcgat cgcgagcgcg gcgaagccgg
490741 gcgtggcggg tcgcgtttat ggcataggag tagaaagaac tggtggctga actgaagcta
490801 ggttacaaag catcggccga acaattcgca ccgcgcgagc tcgtcgaact agccgtcgcc
490861 gccgaagccc acggcatgga cagcgcgacc gtcagcgacc attttcagcc ttggcgccac
490921 cagggcggcc atgccccgtt ctcgctgtcc tggatgaccg ctgtcggcga acgtaccaac
490981 cggctgctgc tgggcacttc ggtgctgacc cccaccttcc gctacaaccc cgccgtcatc
491041 gctcaggctt tcgccaccat gggatgcctg tacccgaacc gtgttttcct tggcgtgggc
491101 accggtgagg cgctgaacga aatcgccacc ggatacgagg gcgcctggcc ggagttcaag
491161 gagcggttcg cccggctgcg tgaatcggtg gggctaatgc ggcagctgtg gagcggtgac
491221 cgcgtcgact ttgacggcga ctattaccgg ctcaagggtg cctcgatcta cgacgtgccc
491281 gacgggggcg tgcccgtcta catcgccgcc ggcggcccgg cggtggccaa gtacgccggc
491341 cgcgccggtg acggcttcat ctgtacgtcc ggcaagggcg aggagctcta caccgagaag
491401 ctgatgccgg cggtacgaga aggcgccgct gccgctgacc gatccgtcga cggcatcgac
491461 aagatgatcg aaatcaagat ctcctacgac cccgacccgg agctggcatt gaacaacacc
491521 cggttttggg cgccgctgtc gttgacagct gagcagaagc acagcatcga cgacccgatc
491581 gagatggaga aggccgccga tgcgctgcca atcgaacaga tcgccaagcg ctggatcgtg
491641 gcgtcggacc ccgacgaagc cgtcgaaaag gtaggtcaat acgtgacatg gggcctgaac
491701 cacctggtat ttcacgcacc aggacatgac cagcgccggt ttctggagct cttccagtcg
491761 gacctggcac ccaggttgcg gcgacttggc tgactcctcg gcgatctacc tcgccgcacc
491821 agaatcgcag acgggtaagt cgacgattgc actggggctt ttgcaccgac tgaccgcgat
491881 ggtcgccaaa gtcggtgtgt tccggccgat tacgcggctc tctgcggagc gggactacat
491941 cctggaacta ctgctcgcgc acaccagtgc gggcctgccc tatgagcggt gtgttggcgt
492001 gacctaccag cagctgcatg ctgaccgcga cgacgcgatc gccgaaattg tcgattcgta
492061 tcacgcaatg gccgacgagt gtgacgcggt ggtggtcgtc ggcagtgact acaccgacgt
492121 caccagcccc accgagctct cggtcaacgg ccggatcgcg gtgaacctcg gcgcgccagt
492181 gttgttgacg gttcgggcga aggaccgcac ccccgatcag gtcgccagcg tcgtcgaggt
492241 ctgcttggcc gagctggaca cccagcgcgc tcataccgcg gcggtagtgg cgaaccggtg
492301 cgagctgtcc gcgataccgg ccgtgaccga cgcgctgcgc aggttcaccc cgcctagcta
492361 tgtagtgccc gaggaaccac tgctgtcggc gccgaccgtt gccgagttaa cgcaggctgt
492421 gaacggggcg gtggtaagcg gtgatgttgc gctgcgcgaa cgtgaggtga tgggcgtgct
492481 ggccgcgggt atgaccgccg accatgtgtt ggagcggctg accgatggca tggcggtgat
492541 tactcccggc gaccgctcgg acgtggtgtt ggccgtcgct agcgcccatg cggccgaagg
492601 gtttccgtca ttgtcatgca tcgtcctcaa tggcgggttc cagttgcatc cggcgatcgc
492661 cgccctggtt tccggcctgc gattgcggtt acctgtcatc gccaccgcgt tgggcaccta
492721 cgacaccgcc agcgctgccg cgtcggcccg cgggctggta acggcgacgt cgcaacgcaa
492781 gatcgacacc gcgttggagc tgatggaccg ccacgtggac gtcgccggtc tattggcgca
492841 gctgaccatt cccatcccta cggtcactac accacagatg ttcacttatc ggctgctgca
492901 gcaggcccgt tcggacctca tgcgcatcgt ccttcccgaa ggggacgacg atcgcatcct
492961 caaatcggcg ggccgcctgc ttcagcgcgg catcgtcgac ctgaccatcc tgggcgatga
493021 agccaaagtc cgtctgcggg cagcggaact cggtgtggac ctggacggcg ccacggtaat
493081 cgagccatgc gcaagcgaac tgcacgatca attcgccgac cagtatgcgc agttgcgtaa
493141 ggcgaaggga atcaccgtgg agcatgcccg cgaaatcatg aacgatgcca catatttcgg
493201 caccatgctg gtgcacaact gtcatgccga cggcatggta tcgggtgctg ctcacaccac
493261 ggcgcacacc gttcgtccgg cgctggagat catcaagacc gttccgggca tatccaccgt
493321 gtccagcatt ttcctgatgt gtctgccgga tcgggtactg gcgtacggcg actgcgcgat
493381 catcccgaac ccgacggtgg agcagctcgc tgatatcgcc atctgctcgg cacgcaccgc
493441 cgcacagttc ggcatcgagc cccgggtggc catgctgtcc tactccaccg gtgactcggg
493501 gaaaggtgcc gacgtcgaca aggtcagagc ggcaacggag ttggtgcgcg ctcgggagcc
493561 gcagctgccg gtcgagggtc ccattcaata cgacgccgca gtggaaccgt cggtcgcggc
493621 caccaagttg cgcgattcgc cggtggccgg ccgcgcgacg gtgctgatct tccccgatct
493681 caataccggc aacaacacct acaaagcggt gcagcgttct gcgggtgcga tcgcgatcgg
493741 cccggtgctg cagggcttac gcaagccggt gaacgaccta tctcggggtg cactggtcga
493801 cgacatagtc aacaccgtgg ccatcacggc gattcaggcg cagggcgtcc atgagtagca
493861 ccgtgctggt gatcaattcc ggctcgtcgt cgctgaagtt ccagctcgtc gagccggtcg
493921 ccggcatgtc acgtgccgcc gggattgtcg agcggatcgg cgagcggtca tccccggttg
493981 ccgatcacgc ccaggcgctg catcgcgcat tcaagatgtt ggccgaggac ggaattgacc
494041 tgcagacctg cgggctggtg gcggtcggac accgggtggt ccacggcggc acggagtttc
494101 accagccgac gctgctggat gacacggtga tcggcaagct tgaggagctg tcggcgctgg
494161 ccccgttgca caacccgccg gcggtactgg gcatcaaggt ggcacgcaga ttgctggcca
494221 atgtcgcgca cgtcgcggtg ttcgatacgg cctttttcca tgacttgccc ccggcggccg
494281 cgacctatgc catcgaccgc gacgtcgccg acagatggca tatccgccgc tacggatttc
494341 atggcacttc acaccaatac gtcagcgagc gggccgccgc cttcctgggc cgcccgctcg
494401 acggtttgaa tcagattgtg ctgcatctgg gtaacggtgc ctccgcctcg gcgattgccc
494461 gcggccggcc ggtggaaacg tcgatgggcc tgacaccgct tgagggcttg gtgatgggca
494521 cccgcagtgg cgacctggac ccgggcgtca tcagctactt gtggcgcacc gcgaggatgg
494581 gtgtcgagga catcgaatcg atgctcaacc atcggtccgg gatgttgggg ttggcggggg
494641 agcgggattt tcgccgtcta cgactagtga tcgaaaccgg ggacaggtca gcacaattgg
494701 cgtatgaggt gttcatccac cggttgcgca agtaccttgg tgcctatctg gcggtgttgg
494761 gccacaccga tgtggtgagc tttaccgccg ggatcggcga aaacgatgcg gcggtgcggc
494821 gggacgcgtt ggctggcctt caggggctag gtatcgcact cgaccaagac cgcaacctgg
494881 gcccggggca cggcgcccgg cggatttcgt cagacgattc accgatcgcc gtgctggtgg
494941 ttcccacgaa tgaagaactg gccatcgccc gcgattgcct gagggtgctg ggcggacgcc
495001 gagcgtgaat catacgacag cccgccggcg tgtcgcgtcg tgcgattcac actcgggcgg
495061 cttagaacgt gctggtgggc cggaccttgt tggccatgtc caccagcgtg tagcgatgcc
495121 gttgagtggg agctacccgg gccaggctgc gcagtgacgc ctcgacaccc agccgcagcc
495181 cgtgactggt gaacgggaaa ccgaggatgt ggttggtgct ggccttgttg tccttcagcc
495241 agtccagcgc gccacccagc accagggcgc ggatctgcag cacgcgtggt tcggtcgggg
495301 gcagcgcctc cactcttcgg gcggcgtcgc ggatctgttc ctcggtgact tcactcgttg
495361 accggccgga caacagagtc accgcgctgg tcagccgtgc cgtggtgaaa tgccgagaag
495421 tgggcggtac ctcgtcgagc gtgcgcacgg cgccgacccg atcaccttcg gccgaccggg
495481 ctctggccag tccgaaagcc gccgagatca cgccgtcgtt ggtgctccac accgtctgat
495541 agaacttgtg ttcgtcggtg ttgccggcta gttcggcggt ggcggccagg gcgagcttgg
495601 gcgccagctc gccgggaaag gtatccagca cctcggtgaa atgtttggtg gccgagtcat
495661 agtcgccggt gagcagctcg gcgacggccc ggtaccagac caatcgccat cgccagccaa
495721 cgcgttcggc cagatcgtcg agttttcggg tggccttggc cacatcgccg agatccagca
495781 gcgcgcggac ttccattagc ggcagctcca ctgactcgga gaagtcgacg ccgtcggcgt
495841 ccagcgcacc gtggcgggcc gcgcgcagcg agtctagggt ctgcaccggc tgggagagca
495901 ccgtggcctg caggaccgaa gctgcgacgt cggtcggatc gaccagcggc accgacagcg
495961 cggtcacgat ctcgttggcg gtcagcttct ccgcgtgcac ctgcccgtcc agatacacgt
496021 cggtgtgcgc caccagcagg tccactccaa atgtcgaccg actgggactg aagatcgttg
496081 atagccctgg ccgcggcacc ccggtgtcct gggcgaccac ctcccgcaac acgcccgtca
496141 attgcgcgga catctcttcg gcggtggtga accgttgccg cggatcgggg tcgatggccc
496201 tgcgcagcaa ccggccgtaa gagtcgtagg ttttcagcac cgggtcgtct tcgggtagcc
496261 catccacata acggccattg cgggtgggca ggtccagcgt gagcgccgcg agcgtgcgtc
496321 ccacggtgta gatgtcggtg gccaccgtcg gaccggtccg cacgatctcg ggcgcctgga
496381 agcctggggt cccgtagagg tagccgaacg agttgatccg cgataccgcg cccaggtcga
496441 tcagcttgag ctgttcctcg gtcagcatga tgttttccgg cttcaggtcg ttgtagacca
496501 agccgatgga atgcaggtag ctcagcgccg gcaggatctc cagcaggtag gcgatggcct
496561 ccgcgacggg cagtttctga cccttgctgc gtttgagcga ttgcccgccg acgtattcca
496621 tcacgatgta gccgaccgga tccccgtgcc tgtcggtgtg ctcgacaaag ttgaagatct
496681 gcacgatcga cgggtgcacc acctcggcca ggaactggcg ttcggccatc gccattgcct
496741 gcgcttcggc atcaccggaa tgcaccaggc ccttgagcac caccggacgg ccgttgacat
496801 tgcggtcgag agcgaggtag atccagccca gtccgccgtg cgcgatgcag cctttgacct
496861 cgtactggcc ggcgacgatg tccccgggat ttagctgcgg caggaacgaa tacgggctgc
496921 cgcaataggg acaccagccc tctgaagctc ccttggtctc cgagtcggac cggccgacgg
496981 gacgtccaca gttccagcag aaccgcttgg actccggcac caccgggttg gtcatcaggg
497041 cctcaagcgg atcgatatcg ggcgcccgcg ggatttccac caggccgccg cccagccgtc
497101 tgaccggcgg gcgcacccgg ctggtggtgg ccatccggtc ttgcggctcg gtgtccgggc
497161 cgagcgtcgg atgggggaag ttgtcctcat cgccgaaatc ggggcggaac accgcctggg
497221 tgctcagggg tcgaaccgtc gcggacgtcg cggtctgggc gtccgccggt tgggtgccgg
497281 ggcccgaacg ttcggtctct gacgctttgg ccatcagtcc acatacctcg gcgtgggcgg
497341 ggcgggggct gggccgagca ccgtcagcca cttgcgatac aacgtgttcc aggtgccgtc
497401 attgcggatg cgttcgagcg tgccgttgac gaaccggacc aatccggtgt tgtccaggtt
497461 gatcccgacg ccgtagggct ggtcggccat gtcgggcccg acgatatgca ggtaggggtc
497521 ttcctctacc agcccggcca ggatggtgtc gtcggtgctg acagcgtcga tctcgcgctg
497581 ctgcaaggcc accaagcagt ccgcccagtt caccaccgac acaatgacgg gaggcggtgc
497641 gatctcccgg atacggcgca acgatgtggt gcccctggcc acacagaccc gcttgcccga
497701 caggtcggac acctttgtga tcggcgagtc acgcggggcg aggatgcgtt ggttggcgtc
497761 gaggtagacg gtggagaagt tgaccagctt gcgccgctcg caggtgatcg acatcgtctt
497821 gacgacgatg tcgacctgcg acttctgcag cgcggtgacc cgctccgcgg ccgacaggat
497881 ccggtactcg acatgtgacg ggacaccgaa gatgtcgcgt gccacttcgc cggcgatgtc
497941 aacgtcgaag ccggtgatct cgccggtgat cgggtcgcgg aagctgaaca ggttgctgcc
498001 gatgtcgagt ccgacgatca gcctgccgcg cgcgcggatg tcggccaccg cggcgtcggc
498061 ctcggccttg gtggcaaagg ggcgcaggct ggcggtggga tcgcagtcct ggctcgaact
498121 gtccggcggc agcgggggtt gcggtggcat gatctccatg ccgaccggtg tgggcagcgg
498181 cagcgtcggc gtcgcctcca cccccagcgt ttccgagtgg ccgcaactgg ccagcaccat
498241 cgccaaggcc agcggcgcga gtggggctgc cgcccgcgcc aggagggccc ggcgcgtcat
498301 caccgatact ctttcagccg gggccacagg ccgagcgcga cggcaatggc ggcacctaag
498361 ctgagcacca cgccgcccac ctgcgcgcct gccagcccgc gatgcgcatt gaggatgtcg
498421 tggcgcagtt gggtgcggct ttgtcccatg gctttggtca gtgcttcgtc gagcttgtcg
498481 aatgcggggg tagcatcgtc ctcgccttta cccagtgcca cctgagtggc agcccgatag
498541 ttgccgacgg agatgtcgga attgatccgg tcgttggcct gccgccagcg caccaacagc
498601 tggtcggcgc cctgcagatc gggtttgtcg acggcgtggc ggcgggccat gtagtcgttg
498661 agctggcgtt gcatggcgtc gatgcgctga tagaaggcct gcttgcggac ctcttcgtcg
498721 ccgcgccgga tcagcgacag tgtctcgtcg gcccgtgcct gttgggcggt gatcgccagg
498781 ttggtgatgg tcttgagtga ctcagccgcg gtatctttcg cgctacggct ggccgttgta
498841 gagatggtca gcgcagttcc cacccacacc accatgacga gaataccgag cgcgcccacg
498901 acaagaccgg ggttaatccg tcgcctggtg cgccgggcca gccagcgatg tgcgaacgca
498961 ccgaagacca cggtggtggc gaccaccagg atcaccgggg ccgggatctg ggtcgacgcg
499021 gtggtttccc gatctacccg tgctgatgtc gcctggtaga gccgttgcgc gtcgggcagg
499081 atcgtcgatt gcatcagccc cgacgcctct gacagatatg acgacccgac cgggttgccc
499141 gcccggttgt tggcgcgggc gatctcgacc aggccggtgt agacggccaa ttcggcgttg
499201 atccggccca gcaattgcac caacgattcg tcggtgagcc cgctcgaggc ccgggttacc
499261 gctaccgagg catcggtaat ggcctgctcg tagcgcagcc gaacgccgcc cggctcggct
499321 tgggctatga acgcggtggc ggccgcggca tcagccaccg acagcgtggt gtacagccgt
499381 ccagccgcga acgacagcgg ctcggtgtgg tcgagcaccg cggtcaacac ctgctgccgg
499441 tgttcgatgg tggtggaggt agcgaaggcg ctggccacgc cgagagccgc caacacgatg
499501 ccgatcgtca tgattcggcc gggtgtcgtc gagatgaacc accgccgggg atgtgccggt
499561 tcggcgggcg agcgtgatcc cagcggctcg gtcgacgggt gcgccagctc aaccgtcacg
499621 tctgttagga cctcatcttt cggctaacgc aacgaaactc tataagcgaa ttctaagaga
499681 aggttccgac agatggtgtt aggcatacgc aattgcccag ttgcccgcct gcatattctg
499741 aacaggtgcg gggcgacggt gacggatggg tggtgtccga cagcggcgtt gcgtactggg
499801 gccgctacgg tgcggccggt ctgttgcttc gggctccgcg gccggacggc acccccgcgg
499861 tgctgctgca gcaccgcgcg ctgtggagcc atcagggcgg cacctggggc ttgccgggcg
499921 gtgctcgaga cagccacgag acgccggaac agaccgcggt ccgcgaatcg agcgaggagg
499981 cgggcctgtc cgccgagcga ctcgaggtgc gggccacggt ggtcaccgcc gaggtgtgcg
500041 gggtcgacga cacgcactgg acctacacca ccgttgtcgc cgatgccggg gagttgctgg
500101 acaccgtgcc caaccgggaa agcgccgaac tgcgctgggt ggccgagaac gaggtggccg
500161 acttgccgtt acatcccgga ttcgccgcca gttggcaacg actgcggacc gctccggcga
500221 ccgtgccact ggcccggtgc gacgaacggc ggcagcggct gccgcgcacc attcagatcg
500281 aggccggggt tttcctctgg tgtacgccgg gcgacgcgga tcaggcgccc tcgccgctgg
500341 gtaggcggat cagttcgctg ctgtaagcgc cgaccggagc tgctcggccg ccgcacgtgg
500401 gtcgtcagcc gaggtgatcg cccgcaccac cacgatccgg cgagcgccgg catcgagcac
500461 ggccggcagc cgttgcgcgt tgatgccgcc gatagcgaac cacggcttgt cgtcgccgcc
500521 gagttcggcg gcgacccgta ccagccccag acccggcgcc gcacggccag gcttggtcgg
500581 tgtcggccaa catggtccga cacagaaata gtcggcgtcg ccggcggcgg ccgcagcaac
500641 ctggtcgggg tcgtgggtgg accggccgat gagggtatcc ggtgccagga tctgtcgtgc
500701 gacgttcacg ggcaggtcgc gttgacccag atgcagcacg tcggcgccgg ccgcgcgggc
500761 aatatcggcg cggtcgttga ccgcgaatag ggcgccgtac cggtgcgctg cgtcggccag
500821 gatctcgcag gcggccagtt cgtcacgcgc ctgtagcggg ccgaaccgca gctcaccggg
500881 tgagcccttg tcgcgcaact ggatgatgtc cactccgccg gccagggcgg cctcggcgaa
500941 ctgagccaag tcgccgcgtt cccgacgggc gtcggtgcac agatacagcc ttgccgatgc
501001 cagacgggat tcgtgcacat cgtgacgcta gcgcgctagc gtggaaccct gtagacacgg
501061 gagtcccggg agcggggtct gagagtgggc gcgcctgccc ttaccgtcac acctgatccg
501121 gatcatgccg gcgaagggag gtcaaggatg gcgtccgacc tacacaccgg gtcgctggct
501181 gtcatcggcg gcggtgtcat cgggctgtcg gtggcccgcc gtgccgccca agccggctgg
501241 ccggtgcggg tgcaccgcag cgacgagcgg ggggcgtcct gggttgccgg cggcatgctg
501301 gccccacaca gcgaaggctg gcccggcgag gaacggttgt tgcggctagg cctgcagtcc
501361 ctgcggcttt ggcgtgaggg cagctttctc gacgggctgg gcccgcaact ggtcaccgcg
501421 cacgagtcgc tggtggtggc cgtcgaccgg gccgacgtcg ccgacctgcg cactgtcgcg
501481 gactggttgt ccgcacaggg gcacccggtg atctgggagt cggctgcccg tgacgtcgaa
501541 cccctactgg cgcaaggcat ccggcacggg tttcgggcgc ccaccgaact ggccgtcgac
501601 aaccgcgccc tgctcgacgc gctgtgccgt gactgcgagc gactcggagt tcgctggagc
501661 tcacaggtga gcagcctgtc cgacgtcgat gcgcacacgg tggtgatcgc caacggcatt
501721 gacgccccgg ccttgtggcc cggcctgccg atacgcccgg tgaagggtga ggtgctgcgg
501781 ctgcgatggc gaccaggttg tatgcccttg ccgcagagag tgattcgtgc ccgtgtgcgt
501841 ggacgacagg tctatctggt gccacgttcg gacggggtgg tcgtcggcgc cacccaatac
501901 gagcacgggc gcgacaccgc gccggtggta tcgggagttc gtgacctgct agacgatgcg
501961 tgtaccgtgc tgccggcgct gggtgagtac gagctggccg agtgtgaggc cggactgcgc
502021 ccgatgacac ccgacaactt gccgctggtc caacgcctgg attcgcggac cctggtcgcg
502081 gccggtcacg gccgatccgg attcctattg gcgccgtgga ctgccgaaca gattgtgtcc
502141 gaactcgttt cggttggggc cgcctcatga tcgtcgttgt caacgagcaa caggtcgagg
502201 tcgacgagca gaccaccatc gccgcgctgc tggattcgct gggcttcggg gaccggggta
502261 tcgctgtggc gttgaacttt tcggtgctac cacgatcgga ctgggccacc aagatctgtg
502321 agctgcgtaa gccggtgcga ctagaggtgg tgacggcggt gcagggtggc tgagtccaag
502381 ttggttatcg gtgaccgcag cttcgcctcg cggctcatca tgggtactgg gggtgcgacc
502441 aatctggcgg tgctagagca ggctctgatc gcctcaggta ccgagctgac caccgtcgcg
502501 atacgccggg tcgacgccga cgggggaacc ggcctgctcg acctgctcaa ccggctcggc
502561 atcacaccgc tacccaacac cgcggggtcc cgcagcgccg cggaagcggt cctgacagcg
502621 cagttggccc gtgaggcgct gaacaccaac tgggtcaagc tcgaggtgat tgccgacgaa
502681 cgcaccctgt ggcctgatgc ggtcgaatta gtccgggctg cagaacaatt ggtggacgac
502741 ggatttgtgg tcctaccgta cacaaccgac gacccggtgc tggcccgccg gctagaagat
502801 accggttgcg cagcggtgat gccgctgggt tcgccgatcg gcaccggcct tggtatcgcc
502861 aacccgcaca atatcgagat gatcgtcgcc ggtgcccgcg ttcccgtggt gctggacgcg
502921 ggcatcggta ccgccagcga tgccgcgttg gcgatggagt tgggttgcga tgccgtgttg
502981 ttggccagtg cggtgacccg ggccgccgac ccgccggcga tggccgcggc gatggccgcc
503041 gcggtgaccg ccggatatct ggcgcgttgc gcggggcgga tcccgaaacg cttctgggct
503101 caggcttcca gcccggcacg ataaccaaaa cggtgaagcc acggggtgcg ggcggcccgc
503161 taccggtccg attgccccgg atgtggcagc ttgcgcatac agtgcagcct tatacacgcc
503221 gacctgttgg ctgccgccga ctacaacgtt gtgggattgg cggcggcggt gctatcggtg
503281 tgggcctact tggcgtagac ctatggccga ctggtgggac gacgagtccg gagttggcag
503341 caccatcgcc agtgttccgt agcggcattg tcgctggtag tgctttggtt tgtgctgtgt
503401 aacctccggt ttaggccatt caacgctctg ttcgtttgat tggtcggtgg gatgcgaaag
503461 ctgcgcggcg acaggcgcgg tctaatctgg gcgcgatggt gaacaaatcc aggatgatgc
503521 cggcggtgct ggccgtggct gtggtcgtcg cattcctgac gacgggctgt atccggtggt
503581 ctacgcagtc gcggcccgtt gttaacggcc ccgctgccgc agagttcgcc gttgcgttgc
503641 gcaaccgggt gagcaccgac gcgatgatgg cgcacctatc gaaactgcag gacatcgcca
503701 acgccaacga cggcactcgc gcggtgggca cccctggcta tcaggccagc gtcgactatg
503761 tggtaaacac actgcgcaac agcggttttg atgtgcaaac cccggagttc tccgctcgcg
503821 tgttcaaggc cgaaaaaggg gtggtgaccc tcggcggcaa caccgtggag gcgagggcgc
503881 tcgagtacag cctcggcaca ccgccggacg gggtgacggg cccgctggtg gctgcccccg
503941 ccgacgacag tccgggctgc agtccgtcgg actacgacag gctgccggtg tccggtgcgg
504001 tggtgctggt agatcgcggc gtctgtcctt ttgcccagaa ggaagacgca gccgcgcagc
504061 gcggtgcggt ggcgctgatc attgctgaca acatcgacga gcaggcgatg ggcggcaccc
504121 tgggggctaa taccgacgtc aagatcccgg tggtgagtgt caccaagtcg gtcggattcc
504181 agctacgcgg acagtctggg ccaaccaccg tcaagctcac ggcgagcacc caaagtttca
504241 aggcccgcaa cgtcatcgcg cagacgaaga cggggtcgtc ggccaacgtg gtgatggcag
504301 gtgcgcattt ggacagcgtt ccggaaggac ccggcatcaa cgacaacggc tcgggagtgg
504361 ctgcggttct ggaaacggca gtgcagctgg ggaactcacc gcatgtgtcc aacgcggtac
504421 ggttcgcctt ctggggcgcc gaggaattcg gcctgattgg gtcacgaaac tacgtcgagt
504481 cgctggacat cgacgcgctc aaaggcatcg cgctgtatct gaacttcgac atgttggcgt
504541 cgccgaaccc gggttacttc acctacgacg gtgaccagtc gctgccgcta gacgcccgcg
504601 gtcagccggt ggtgcccgaa ggctcggccg gtatcgagcg cacgttcgtc gcctatctga
504661 agatggccgg caagaccgcg caggacacct cgttcgacgg tcggtccgac tacgacggct
504721 tcacgctggc gggtatccct tcgggtggcc tgttctccgg cgctgaggtc aagaagtccg
504781 ccgagcaagc cgagctctgg ggcggcaccg ccgacgagcc tttcgatccc aactatcacc
504841 agaagacaga caccctggac catatcgacc gcaccgcgct cggtatcaac ggcgctggcg
504901 tcgcgtacgc ggtgggtttg tatgcgcagg acctcggcgg ccccaacggg gttccggtca
504961 tggcggaccg cacccgccac ctgattgcca aaccgtgatc cgggcctgat ctcgccactg
505021 accccgcacc gaccgatcta gaatgggatt tccttggtgc atgccgggcg ggacggggtt
505081 aggagatgca tggtcgcggg cggtatcgac ctctggtccg ctgtgttcgc cctcgccggg
505141 tggccgcgtc ggtgcggacc ccgatcgcct gtctagcggc ggtggtcgtg atagccggct
505201 gcacgaccgt cgtcgacggg cgggcgctgt ccatcctcaa cgacccgttc cgggtggggg
505261 gtctgcccgc gaccaacggt ccgagcggcg cccgccccga cgcaccggct gcgtcgggca
505321 cggtgatcaa caccaacaac ggagcgatcg acaagttgtc gttgttgtcg gtcaacgaca
505381 tcgaggacta ctggatggcg gtctacagcg aatcgctgaa gggcaccttc cggccggtcg
505441 gcaagctggt gtcctacgat tccaacgacc caagtagtcc gatcgtctgc cacattgaca
505501 cctatcagct cgtcaacgcc tttttcagct ctcggtgcaa cttgattgcc tgggatcgag
505561 gggtcttcat ggcggtcgcg caagaatact tcggcgacat gtccgtcaat ggtgtgctgg
505621 cacacgaatt cgggcatgct ctgcaagtga tggcgaattt ggttaccagg aaagatccca
505681 ccatcgtccg cgagcagcaa gcggattgct tcgccggggt ctatctgtgg tgggtggccg
505741 aaggtaagtc gacacgcttt acgctgagca ccgcggacgg gctcgaccac gtgctcgccg
505801 gcatcatcac cacccgagac ccggtgatgg aagccgatgc ggaaaacgac gacgaacatg
505861 ggtcggcctt ggatcgggtc agcgcgttcc agctgggctt catcaacggc acgccggcgt
505921 gcgcggcgat cgacgaggac gaagtcgagc ggcgccgcgg tgacctgccg acggcgttgc
505981 gggtcgatgc cagcggcaac ccagagaccg gcgaggtcgg aatcaacgaa gagaccctct
506041 cgacgttgat ggagttgatg ggcaagatct tctcgccgaa gaatccgccc acgctgtcct
506101 accagccggc cggttgccca gacgccaagc ccagcccacc ggccgcctac tgtccggcca
506161 ccaacaccat cgtggtcgac ctgcccgccc tggcgaggat gggcaaggtg gcctcggcag
506221 cggaacacag cctgccgcag ggcgatgaca cgtcgttgtc gattgtgatg tcgcggtacg
506281 cgttggcggt gcagcacgaa cgcgggctgc cgatgcagag cccgtggacc gccttacgga
506341 cggcgtgcct gaccggcgtt gcgcaccgca agatggccgt gcccatcgac ctgccctccg
506401 gccagcaact cgtacttacc gcgggtgatc tcgacgaagc ggtttccggg ttgctgacca
506461 accgcatggt cgccagtgac gccgacggtg tcagcgttcc ggccggtttc actcggatag
506521 ccgcgttccg tgccggcgtg ggcggcgaca tggacgcatg ctatgcccgg tatccgggat
506581 aggactggcc ctgatgttga tcgttgtgca cccacatcac caaaaacccg gtgaccagca
506641 accaccccag ggcaacggac gggatcgccc aggcgcgacg tacgagtagt gcggtgtcac
506701 aacgcgtgac cagggcctga gtgttgtcgt tgccgtcggc gtacagcgcc tgggtgaggt
506761 tggagcgcca gccgctgcca caggtgacct tgatgccata cgcatcgtat tgatccaggt
506821 agaccggaaa ccacagcgcc atcagaccaa tgaccgccag cagcaggcca gtaattccga
506881 tgaacatctg gcgacgattc acggcttctc catgtcttgc gatgtgcatt cgggattcgg
506941 gcgccgcagc gctcgcgtca tgcaagcgca aatgcgggct ttgccaacaa aggccgggtg
507001 gccacgccca ggcaagttgt gagggaggcc ccccggggcc gcaaccatgt taacgcgcgt
507061 ccgcctaagc attcagcgcg ccgtgcccta ccggcactac gcccgggcgt gcgtgcggaa
507121 cctgacagag ctcacgctat ttggcccgcc gacagacgta gcgccgcatc gaccgccagc
507181 ctggcgacat cgagggtctt cgagcccaag tcatgtcggg cgccggtgat ctcgacgacc
507241 tcggtcggtg ccgagaccat cgccgcggcg gaacgcacct gggccagcgt gccgaacggg
507301 tccgccgttc cgtgggtgaa caccgtcggc actgcgatcc ccggcaagtg ctcggtacgg
507361 acgcgttccg gctttcccgg cggatggacc ggataggaga acagcgtcag cacgtcgacc
507421 ggtgcctgcc cggccgccac caccatggac gtctgccgac cgccgtagga atgtcccccg
507481 gcgatcagcg gaccctcggc aaggccgcgg cacagctgga tcgcttcgac gatgccggca
507541 cggtcgcctg accccgagcc ggatggcgga ccggtgggtc ggcgtcggcg gtagggcagg
507601 ttgtagcgca cggccagcca tcctcggcgg gtccattcgg cgcaaacctg ttgcaacagt
507661 gtggattcgc ggctaccgcc cgcgccgtgg gtaaggacga ctaccccgtg tggtgggccg
507721 gccggttggt gtgcaacgcc ggcgatctga tcaaggttca tgacagccga aacagcggcg
507781 aaacgggccc gtggccgcgg cccagtggat aggccgcgcg caggcattcg gtaacccatc
507841 gcttcccgaa gtccaccgcg tcgggcacgg tgaagccgtg cgccaacgcg gcggcgatcg
507901 cggtcgccag cgtgtcacca ccgccatggt catcgccggt gggtagtcgc tgcgcgtcga
507961 actggtagca gctgacgccg tcatagagca ggtcgcagct gccgtccgac gagcgcaggt
508021 gtccgccttt gaccagcacc cactgcggcc ccagcgcatg cagggctttg gccgccgcac
508081 gctgcgactc ggcgtcgact acctcgatat ctaccagcag gcgcgcctcg tcaaggttgg
508141 gggtcagcag cgtcgccaac gggaacagct gaccgcgaag cgaatccagg gcagacggtg
508201 ccaacagcgg gtctccgtgc atggatgcgc ataccgggtc gacgacgagc ggaacggaca
508261 gctcgagccg acgccaggtc gcggccacgg tcgcaacgat gcgcgacgag gccagcatcc
508321 cggtcttggc ggcttgaacg ccgatgtcgg tgacgaccgc ctcgatctgg ccggccacca
508381 catcgttggg aacttcatga atatccttga ctcccaacgt gttctgtacg gtaaccgccg
508441 tgactgcgac gcacgcgtgc actcctagca gtgccatcgt gcgcatatcg gcttggatgc
508501 cggcaccgcc cccggagtcc gatccggcga tgctcaacac ccgcggcggc gtcattcccg
508561 gcggtgccag cgggaggtag ttcactgggt tatcgggaga tacacccgat tgccgtgctc
508621 tgcgaattca cgtgactttt cggccattcc ggcggcgagc acggcttcga tgtccgcttc
508681 ggtctcaagc ccgtgttcgg cggcgtactc acggacgtcc tgggtgatgc gcatggagca
508741 gaacttcggt ccgcacatcg agcagaagtg cgcggtcttg gccggctccg ccggcagggt
508801 ttcgtcgtgg aattcccgtg cggtgtcggg atccagcgac agtgcgaact ggtcgttcca
508861 gcggaactcg aaacgcgccg tgctcaaagc gtcgtcgcgc tcctgggcgc gcggatggcc
508921 cttggccaaa tcggccgcat gcgcggcgat cttgtaggcg atcaccccgt ccttgacgtc
508981 cttgcggtcc ggcaacccga ggtgctcctt gggggtgacg tagcacagca tcgcggtacc
509041 ggcttgggcg atgatggccg caccgatcgc cgaggtgatg tggtcgtagg ccggcgcgat
509101 gtcggtggcc agcggaccca gcgtgtagaa cggggcctcc tcacacagtt cctcttccag
509161 ccgcacattc tcgacgatct tgtgcattgg gatatggccc ggcccctcga tcatcacctg
509221 tgcgccatgg gctttggcga tcttggtgag ctcgcccagg gtgcgcagct cggcgaactg
509281 cgcggcgtcg ttggcatcag cgatcgaccc tggtcgcagc ccgtcaccga gtgagaaggt
509341 gacgtcgtag cgggcgaaaa tatcgcagag ctcctcaaag ttggtgtaca agaacgactc
509401 ccgatgatgt gccaaacacc acgcggccat gatcgaaccc ccgcgggaca cgatgccggt
509461 gacccgcttg gcggtcagcg gcacataccg cagcagcacc ccggcgtgca ccgtcatgta
509521 gtccacgcct tgctcacact gctcgatcac ggtgtcgcgg tagatctccc aggtcagctc
509581 ggtcggatcg cccttgactt tctccagcgc ctgatagatc ggcacggtgc cgaccggcac
509641 gggagaattg cgcaggatcc actcgcgggt ttcgtggatg ttcttgccgg tggacaggtc
509701 catgatggtg tcggcccccc agcgggtggc ccacaccatc ttgtcgacct cctcggcgat
509761 cgagctcgtc accgccgagt tgccgatgtt ggcgttgact ttcaccgcga acgccttgcc
509821 gatgatcatc ggctcgctct cggggtggtg gtggttggcc gggatcaccg cgcggccgcg
509881 ggcgacctcg tcgcgcacta gctcggcgga catgtcttcg cgggcggcga tgaacgccat
509941 ctcggcggtg atctccccgg cgcgggcccg ctgcagctgg gtgccccgat cgcgaaccac
510001 tccgggccta tgcggcagcc ccgcggtcag gtcgatcacc gtgtccgtgt cggtgtaggg
510061 cccggaggtg tcgtagaggt cgaagtggtc tccggtggac aagtgcaccc gtcgaaacgg
510121 gacttggaga gtagctccgc tgccgggagc ctcgatttca cggtaggcct tggcgctgcc
510181 cgcgatggga cccgtggtca ccgacggttc aacggtgatg gtcatttgca actccctacg
510241 ccggcattac ccggtcaggt tcgtacggtc gacggccccg agccgtcctc tcagcgcact
510301 cggcgtgcgc tcccgcgtgg gtacccccac gctagcgcag cgcggcgccg gtgtgcacgg
510361 acggcccgat gccgcgttag gcctcttcca tcgcctcgcc gagttcctcg aggacccggt
510421 tgtggtggtt atttgccaag atatgtccgg tggcgataac cagggcgacc ggccagtcga
510481 tgagttcgag ggcagcgagt gccgccagac ctccgtagta ggccaggtgc tctggccgcg
510541 gaatcttcac ttggccgcag atcgggaggt tcatcacaat agtctccgct tcgcggatct
510601 tagccacggc ctcacgctga gatgtcgctc gacgcgtatt cttttcggcc atcatttgcc
510661 tttcagtaac gaagggtttg ccgttgtgca gggtggtgcg gtcaccgtcg ggggtatgtc
510721 gacgaggacc gatgcgctgg cggacccttt ggcttcgtcg tttgccttgt tgctgacggt
510781 gcctttactg gagctttacg ccgtgctgtg gcgcgtcggc gtcgtcgagg tccggggggc
510841 gcaccggggg acgcgtcgcg ggaaagcgca tcggtctcgg gtggttgcgg gttcggctgg
510901 cccgatttgt cccgacccgt cagcacacgg ttcagcacgg cgacggcgac ggtcgcagca
510961 gtcgcggctg ctgtcgcctg cgcccagccg agtgggtcga ggggggtgca gccgagcaac
511021 tggctgacga cggggatgct gatcaaggtt gccagcgcgg ccagtgagcc cagtgcggtg
511081 agcacaacca gccaggcatg cgagtccacc aaggtttgac ccaactgagc ggccaccagc
511141 gccaccagcg ccaccgtgga tgcgcggcgc ggcaagccgg tgaaccccgc catcacccag
511201 gccacggtgg ccgcggccgc cgtggtcgcc ccgcggatac cgacggcacg ccatagctcg
511261 cgttgatcgg gaccgcgggt tgccggcgtt accgggtcgc ttggcttgct gaccgcgagc
511321 gccgccgcgg gcagtgcgtc ggtcagcatg ttcaccagca gcagctgacg ggtgttcaac
511381 ggcgaggtcc cggtgatagc gctgccgatg atggcaaagg ccacctcgcc cgcgttgccg
511441 ccgagcagca cagacactgc cgcttgcacc cgctgccaaa gctggcgtcc ttccaggatt
511501 gcgggcagca atgactcgat ccggccgtcg accaacacca ggtcggcggc gactcgggcc
511561 gggtcgctgc cgtgggcgac gacaccgatg ccgacggtgg cggcgcggat cgcggccgcg
511621 tcattggagc cgtcgccgac cattgcgcac acccggccgc tgtgttccag cgtctgcacg
511681 atctgtacct tgttctccgg tgtcatccgg gcgaagatca cccgctcggc taccgctcgc
511741 tcctggtcct tgcgtgacag ggcatcccac tcggcaccgc taatgacctg ctcagggctc
511801 acttgcatgc cgagctcctc ggcgatggcg gcggcggtaa tcgggtgatc accggtgatc
511861 agccggatat ccagatcgtg ctcgtgcagg tccgcaagta gggccgccgc ctgggcgcgg
511921 ggggtgtcgg acaacccaag aaaccccacc agactcaact cgtcgcggca caatctcgcg
511981 atctcgtcgg ggtcgtccac gaccgactgt gcctgttgcg cggtcagctg gcggtgggcc
512041 accgcgatca cccgcaatcc gttggcggcc agttcagcga ccgcgtcgtc catgctcgag
512101 ccgatgcctt cgcacgccgc cagcaccact tcgggcgcac ctttgacggt cagctcggtg
512161 ccggacaccg aggcggaaaa cgacctaccg gagcgaaatg gcaggtgggc ggcgggttct
512221 gcggcgccgg gttcggcacc gtcggtgcca ctggcggcag ccgctgccgc agcttgcacg
512281 atcgcgacgt cggtggcgtg cacctgcggg ccgttcgacg ccggcgcagc gtgcgccgcg
512341 cagcgcagca cttcctcgcg cgagtgcccc gccaccggcc gcacctgcgc cacccgcaaa
512401 cggttctcgc tgagcgttcc ggtcttgtcg aagcagacca tgtcgacacg gccgagcgcc
512461 tccaccgagc gcgggatgcg gaccagcgca ccgaagtgac ttagccgtcg cgcggatgcc
512521 tgctgggcca gtgtggccac cagcggcatc ccttccggca ctgcggccac tgtgactgcg
512581 ataccgctgg ccaccgcttg gcgtaggccc cgccggcgca acagcccaag cccggtgacc
512641 agtgcgccgc cggtcatgct gaccggccag gcctggttgg tgagccgact cagctgatgc
512701 tgcaggccga cgctggacag atcaccggac acgagctcgg ccgcgcggcg ctcctgagtg
512761 tcaggaccca ccgcggtcac caccgcgacc gcggtgccgg acacgacggt cgtcccggca
512821 tagagcatgc agcgacgttc gatcaggtcg acacccggcg tgggttcgac ttgtttggtc
512881 accgacagcg actcaccggt gagcgcggac tcgtcgacct ccacgtcgac ctcctcaatc
512941 acccgggcgt cggcgggaac cacctcgtgg gtccgcacct cgatgatgtc gccgggacgc
513001 agctcctcgg cgcggacttc gatgtacctc ggctggtcgt ccgcgccggc cagcaccttc
513061 ctggcgggtg gaatctgctg agccaacaag cgattcagcc gactttcggc acgcagccgc
513121 tggctggccg cgagaataga gtttccggtg agcaccgaac cgaccatcac cgcgtccacc
513181 ggcgaaccca acaccgcact ggccattgca ccaagcgcca gcataggcgt caacgggtcc
513241 gacaactccg cgcgcatggc cttggtcaac tgccaaagcg cgttcaaggg tgcctgggtt
513301 atttgtgcgc cgcgcttcgc cgtgtgcagg ccaccggcca gcgcacgggc cggatacggc
513361 gaaggcggtg ccttcgccgg tgcctgctcg tccggcgacg gcaaagcttt gcggacttgc
513421 tcgaccgaca ttgcgtgcca ttcatgagcg ggtgccggtc gcggtgcttg cgcgtcgacg
513481 accttgcgtg ccagcaggta tcccgagagc agtccggccg ccgcgccggt ggtcaccggg
513541 ccgggcccca gtccgcggac ccctggcagc atcaacaggg ctcccaaagc cgatgcacca
513601 ccggaaattt cgttacctcg ctggcgtgcg gccctggccg ccggaatcgc gtgcagcacc
513661 ctccaggcgg ctccaagatc gggcagcagg acatctgcgt accagggcgg tgcaccggct
513721 ccaggtggtg gcagcacacc aagcgccaca tcggcagccg aaagcgcttg cttaccaacc
513781 gatgacaaca ccgcgacggt gcggcccgcc tggcgcagct cggccaccgc acgggctagg
513841 gcttcgtcga gggacccgct ggcaccgtcg tcgaggggcc ggatgtcgtc gaacaccggt
513901 cgcaactcgc ccagggcgtc gacatcgacc gaaaccaggt ccgccccggt gcgatgtgcc
513961 tcggcaacca ccgcggaggc cagccggtcg tgcatggggc ggaaaagtgc ctcgactgcc
514021 gaatccgaac cgctggccga gacaccgggt actcggtgcc agcctgggcg caggccactc
514081 tccgtcaaaa cgagttgcgc ccgattccac gctgtggaca gctcgtctgc gccgcaaccg
514141 cggatgcgcg ccacgcgcag gtcatcggtg cacagcacgc gggggtcgat gacgatcgca
514201 tcgacccgat ccaatcggcg caaactctcc ggccgtaacg gcaacaccgc gtgctgatca
514261 gccaaacctt ggccgagcgc cgcggcgaac gcctccggcg tggtccggct ggctttgggg
514321 gtggccacca gcgtcgcggt cgcggccatg tccgcgtcgc gggtcccggc gcccacgagc
514381 accgcgctca gcgcttggat cagcgcgaaa cgcgcgacgc tgcgttggac aggttgcgtc
514441 gaccgtgcgg gacgcggcca aagggattgg ggttggtcgg ccggttcgtc ggcgtgcagc
514501 gcgagctgtg gttcatgccg gcgccaggct ctggctccgg cacggcattc cgcggctttc
514561 agcgcctgga tcgtcagatc caccgacaac gccgccggcg acagcgtgac cgtgtgtgcg
514621 gcggccatgg ccagctcaag gacggtggcg gtcgcctccg tgcctattcg atcctcgagt
514681 aggcggcgca gcaacggctg gtggtccacg gccgccaccg ctgcctcgat gacgagcgga
514741 aatcggggcc agcgcagcgc ccggccgccg agcgctaagc ccagcccggc cgcggtggcg
514801 gctaccgtta cagctctgac cgccagcagc acgccgtcgc ccggcaggct ccccggtgat
514861 tgcgccagct gatcggcggc ttgatctggg tggcggtgtc tttcggcttt ttcggcgtca
514921 tcgacaatgc ggcaaagttc gcgcagtgat gtgtcgggat cgtcgatagc gacgacgaca
514981 cgggacaacg ggtagttcag gctggccgac ccgaccccgg ggtgggcttg gattgcgttg
515041 agcacgacgc gcccaagttc gtcgtcgcct ccgctgcgca agccgcgcac ttcgatccag
515101 gcgcgacgct cgccacgcca acagttccgg ccgagtgtct cgcgggacag ctcgccggaa
515161 agtgccttgg ctcctgcgcg cagcgggatg atggcgacct tcataccggt tccgaccccg
515221 gtcttggcca gggttgccga gaccgctgtc gcggcagtga tcgatgcgcc ggtaagggtg
515281 gcggtcgccc ggaagcccgt ggcgacagca cgcaccggca tagcccgtgc gatggatgca
515341 gcaatgctca agagttgctc aacgccgcca gactagttgg tgctgcgcag ctcagcggtg
515401 cccgctcggc gaccgctcgt cttcctggct gttgtcttgc tcgctttggc tggcgcttcc
515461 tttgcggcag ccggcttgtc gggcaccggc gcaagtttcg ccttcaccgg cggtgcggcc
515521 acctcggggg tgcggttgag cttccgcaat agcaacgctc cgccgcccac ggccaacagg
515581 atcggccaat cgacgagtcc agcgacaccg atcgcaccga tggccaacgc ggctgccgcg
515641 gtcgacttgc tgccgctgct aagccccttc tgaatgcctt tggcggctcc ggtcacaccg
515701 ccgacgatgc cgctcacggc ggcgccaccc accgcacccg cggccgctgt ggtcgccgtt
515761 gctgcaccac tcaccgttcg ccccacggtt cgaactgtcc cgccgaccac actcatgatg
515821 actccctggc ccaaactgca ttcgtttaca aatggtttag ctacagttct acactcgtta
515881 acccgcaccc tgcattcgca ccgctgacga gatttctgtt cagcgctctc gaaatgcaag
515941 cctgccacgc cgccctgact gagacaacgc gcaactgccg cgtgcggcgc gactgccgac
516001 taccgccgta cgccgcctac ccggcgtgca ggtcgacgag caccggagcg tggtcgctgg
516061 gcgctttgcc tttacgctcc tcgcgtacga tctgggcgtc catcacccgg gcggccaacg
516121 ccggcgagcc gaggatgaag tcgatgcgca tgccctgttt cttcgggaac cgcagctgcg
516181 tgtaatccca gtaggtgtaa accccgggtc ccggggtgaa aggccgtact acatcggtga
516241 attgcgcgtc gacaatggcg ttgaacgcct tgcgctcggg ttcggaaacg tgcgtgcagc
516301 cggcgaagaa ttcggtgctc cagacatcat catcggtcgg agcgatgttc cagtcgccca
516361 tcagtgcgat tggtgcggcg ggatcgtcac gtagccagcc ttcggccgta tcacgcagcg
516421 cggcaagcca atccaacttg taggtgtagt gcggatcgtc cagggcgcgc ccgttgggca
516481 cgtagaggct ccacacccgg atgccgccgc aggtggcgcc cagggcacgg gcctccgtcg
516541 tggcggccac ttccggcttg ccgctccagc tgggctggcc gtcgaaccca acccgcacgt
516601 cgtcgaggcc gacgcgggat gcgatcgcca cgccgttcca ctgatcgaag ccgacgtgtg
516661 cgacgtcata gccgagttcg aacagcggca aggccgggaa ttggccgtcc gggcacttgg
516721 tctcctgcat ggccaacacg tcgacatcgg cgcgcccaag ccaatcgagg acacgatcca
516781 accgggtgcg aatcgaattc acattccagg tggccagccg cagcagcggc gatcgcaagc
516841 gcggcgaagc cgggcgttgg gggtggccgc cgtcaattgt gccgtcgggc atggctagaa
516901 ggtatcccag ccgaccgact gggcaggaag atagcggcag tgatggtgca gccggaagcc
516961 cagggactcg gcgaggacgg atgtcgcggt gtcgtgcacg cgcacgtagc cgcgggtcgc
517021 gccgcggccc gctccccagc ccaacagcgc ttcccacaat tggcggccag cggagccggt
517081 cgcggattgc tcgtcggcgg cacgcattgc cgacagaccc acccaccggg tgccgtcggg
517141 tgcgtcggtt accgctgcac gtgcgaccgc cacacccagg tagctgccga atgccaactc
517201 gccgtcgatg acgggggtcg ccatgtcgag gggtaggcgt tggtggtaga gccgcagcca
517261 ggtgtcgtcg gggtggtcca gcaacgtgac cgaccggtcg ggttcaccgg tggacacgtc
517321 acgcaccaac acttgctctc ggcgctcacc tgccaggtcg gccggtagtg gcagcaagcg
517381 gtccgggacg gccagccatg gctgcagatc acggctcgca taccatgcgc tgatttctgt
517441 gatggtgttc gtgtgtgccg agatatccag cggtactgct gaattagcgg ccagtacggc
517501 cccgtgtccg gctcgcagga gccagccgtc cagccaggtt cgttcaacgc cgggccaggc
517561 cgccgcggcg gcgtgttcaa gtgcgcggat cgcggcggtg cgcaccggcg catcggtcag
517621 gacccgcagg gccaccacat cgacgggcga gaactcgacg atggtcccgg tcttggtctg
517681 cactcgcacc gtcggatcga cggctagcag ccgacccacc gcatcggtca gcggtggcat
517741 cgatccggcg ggccggcggt agcgcaccgt tacccgtgtc ccaagccccg gccacgagac
517801 cattagtgac cgaacgggtc ggggtcctcg ccgggcagcc acgacagtcc gggaacgccc
517861 cagccatgtg acttgacggc ccgtttggcg ttgcgggcgt accggccgat gaggcggtcc
517921 aggtacagga atccatcaag gtgcccggtt tcgtgctgca gcatccgcgc gaacaggccg
517981 gtgccctcga tactgaccgg actgccatcg gcgtcgagtc cggtgactcg tgcccacttc
518041 gcgcgtccgg taggaaatga ctcgccggga accgacagac agccttcgtc gtcggtgtcc
518101 gggtcgggca tggtctcagg tatttcggag gtctcaagca ccggattgat gaccacaccg
518161 cgtcggcggg cggtcattgc gcggtccgcg gcgcaatcgt agacgaagag ccgcaggctg
518221 cagccgatct ggttggcagc caggccgact ccgttggcgg cgtccatggt gtcgtacatg
518281 gtggcgatca actgggcgag atccgccggg agtgaaccgt cggcggcgac cgtcaccggt
518341 gtggtcgcag tgtgtaagac gggatcgccc acgatgcgga tgggtacgac tgccatggtg
518401 ggctagctta agcgcgccga cgatacgcgc cgcgaggcgg cgggctgagg aggcgggcaa
518461 tcggcttagg cgcgccgcgg ggcggcgggc atcatcgccg ggtgtgaacc acacgacggc
518521 tggccggcat gtcgcgtcgc aggattcaca ctcggagcat gagccggcgc gccgcgatcg
518581 gcagtcgggt gcaagcaagt cggccgactc gcgggcagga ttaccgcccg acggttcctg
518641 gcgtggttca atattcgccg aagaagcgcc tacgtaggcc aagtcattcg tacacattga
518701 gaattcgccg gaagggccca ggggaaagcg atatggacag cgccatggcg cgggcaattc
518761 gatcggggga cgacgccgag gtcgccgatg ggctgacccg gcgcgagcac gacatcctgg
518821 cgttcgaacg tcagtggtgg aagtttgccg gtgtcaagga agaagccatc aaagagttgt
518881 tctccatgtc ggcgacgcgc tactaccaag tgctcaatgc gctggtggat cggcccgagg
518941 cgctggccgc cgacccgatg ctggtaaagc ggttgcggcg gctgcgcgcc agtcggcaga
519001 aggcgcgggc cgcgcgacgc cttggcttcg aggtgacctg acactctccc cgcttttgcc
519061 ggttgtgtcc cggtgctggt tacagtgggc tcgatgaatg agcgtgtacc cgactcttcc
519121 gggcttcccc tgcgggccat ggtgatggtg ctgttgtttc tcggcgtcgt cttcctgctg
519181 ctcgtctggc aggcactggg ttcgtctccg aactccgagg acgactcgtc agcgatttcc
519241 accatgacca ccaccactgc ggcgccgacg tcgaccagcg ttaagcccgc ggcgccccgg
519301 gccgaggtgc gcgtctacaa catctcaggc acagaaggcg ccgccgcgcg gacggccgat
519361 cggctcaagg cggccggttt cacggtcacc gacgttggga atctatcgtt acccgacgtc
519421 gcggcgacca cggtgtacta caccgaagtc gaaggcgaac gggccaccgc cgacgcggta
519481 ggccggacgc taggagcagc ggtggagctg cgactgccag agctgtccga ccagccgccc
519541 ggggtcatcg tcgtggtgac cggctgacgc tgattcgaac gccaggttag gctctcgcta
519601 tgccaaagcc cgccgatcac cgcaatcacg cagctgtcag cacgtcggtc ctgtccgcgt
519661 tgtttctggg cgccggtgcc gcgctgctga gcgcatgctc gtcgccgcag cacgcgtcta
519721 cagttccggg taccacgccg tcgatttgga ccggatcgcc cgcgccgtcg ggactttcgg
519781 gtcacgacga ggagtcgccc ggtgcgcaga gcctgaccag taccctgacg gcgcccgacg
519841 gcacgaaggt agcgaccgcg aagttcgagt tcgccaacgg ctatgccacc gtcacgatcg
519901 cgacgaccgg cgtcggtaag ctcacgcccg gcttccacgg cctacacatc caccaggtgg
519961 gtaagtgtga gcccaactcg gttgccccca ccggcggtgc gcccggcaac tttctgtccg
520021 ccggcggcca ctaccacgtg ccagggcata ccggcacccc cgccagcggc gacctggcct
520081 cgctgcaggt acgcggtgac ggttcggcga tgctggtgac caccaccgac gccttcacca
520141 tggacgacct gctgagcggc gcgaaaaccg cgatcatcat tcacgccggc gccgacaact
520201 ttgccaacat tccgccagaa cgctacgtcc aggtcaatgg gactccgggt cccgacgaga
520261 cgacgttgac caccggcgac gccggcaagc gggtggcgtg cggtgtcatt ggttccggct
520321 agcttgcctg cccgcaggtc ggccgcccga attgatttcg caggctcacc gcggcccacc
520381 ctcggtgtgg agtgggagtt cgcgctcgtt gactcgcaga cccgcgatct gagcaatgaa
520441 gccaccgcgg ttatcgccga aatcggcgaa aacccgcggg tccacaagga attgctgcgc
520501 aacaccgtag agattgtcag cggtatctgc gaatgtaccg ccgaggcaat gcaggatctg
520561 cgcgataccc tgggccccgc ccgtcagatc gtgcgcgacc gcgggatgga gctgttctgc
520621 gcgggtaccc accccttcgc gcggtggtcg gcccagaagc tcaccgacgc gccgcggtac
520681 gcggagctga tcaaacgcac ccagtggtgg ggccggcaga tgctgatctg gggtgtacac
520741 gtgcatgtcg ggattcgctc ggcgcacaaa gtgatgccga tcatgacgtc gctgctcaac
520801 tactacccgc atctgttggc gctctcggcc tcatcaccct ggtggggtgg cgaagacacc
520861 gggtatgcca gcaaccgggc gatgatgttc cagcagttgc ccaccgccgg gctgccgttt
520921 cactttcaga ggtgggcgga gttcgaaggt ttcgtgtacg accagaagaa gaccggcatc
520981 atcgaccata tggacgaaat ccgttgggat ataagaccct caccccatct gggcaccctg
521041 gaggtgcgga tctgcgatgg cgtgtccaac ctacgagagc tcggcgcgct ggtcgcgctg
521101 acgcattgcc tgatcgtcga tctggaccgc cgcttggacg ccggcgaaac gctaccgacc
521161 atgcctccct ggcacgtcca ggagaacaag tggcgtgccg cccgctacgg cctggacgcg
521221 gtgatcatct tggacgccga cagcaacgaa cggctggtta ccgatgacct cgcggatgtg
521281 ctgacccggc tggagccggt cgccaagtcg ctgaactgtg ccgacgagct tgccgcggtc
521341 tccgatatct accgcgatgg cgcctcctac cagcggcagc tgcgagtggc gcagcagcat
521401 gacggcgatt tgcgcgcggt agttgacgcg ctggttgccg agctggtgat ttagccgatg
521461 cgggctggct gagtgtgacg tccgccagcc gcgaggagat tgaggtttag gtgatggccg
521521 atttcgcgcc ggttgagttg gcgatgttcc cgctcgagtc ggcgccgctg cccgacgaag
521581 atctgccgtt gcacatcttt gagccccgct acgcggcgct ggtccgtgac tgcatggaca
521641 ccgcggatcc tcgcttcggt gttgtactga tctcgcgtgg ccgcgaggtc ggcggcggcg
521701 atacgcgatg tgatgtcggg acgctggcca ggatcaccga atgcgcggac gcgggttcgg
521761 gtcgctatat gctgcgctgc cgggtgggcg aacggatccg ggtgtgcgac tggctgcccg
521821 acgatccgta cccgcgtgcg aaggtacggt tctggcccga ccagccgggg cacccagtga
521881 cggctgccca gctgctggaa gtcgaagacc gggttgtggc gctattcgag cggatcgctg
521941 ccgcccgggg agttcggctg ccggcccgtg aggtggtatt gggctacccg gtggttgacc
522001 cagccgatac cgggcagcgt ctgtacgcgc tggcatgtcg agtgccgatg ggcccggccg
522061 atcggtacgc cgtgctggcg acgccgtcgg cggccgatcg attggtccgc ttgggtgacg
522121 cgctggactc ggtggccgcg atggtggagt tcgagttgtc gacgtaactg ccctacgcgg
522181 tgcgtctgac ccactgggcc tgaaccacat tcactgcgcc gagcaccata tacggacccg
522241 tcaccgccgg caagcgcatc cgggtgcgga accggctcga caatggtcaa cgccttcgca
522301 ccattgccga ccagtacccg caattgctcg acttcatcag tggtcgctag gaccgaaggt
522361 cacccttggt gccgaactta cgcagcgacg ccacctgcag cggatccagc gacgcgcgca
522421 cggtttctcg cgcggtcgcc aggtcggcgg cggtgacgtt ggcggcatcg atggaacgcc
522481 gcatcgcggt aagcgcggct tcgcgcagca gcgccacaca gtcggcggca ctataaccgt
522541 cgagtccggc tgccacctcg tccaggtcga cgtcggagct cagcgggatc gacttgccag
522601 cggtgcgcag gatttcgcgg cgagcggcag cgtcgggcgg ttcaacgaac accagccgtt
522661 ctagccgccc cgggcgcagc agcgccgggt ctatcagatc gggccggttg gtcgcgccta
522721 gcatgacgac atcccgcagc gggtcaatac cgtcgagctc agtcagcagc gcggccacca
522781 cccggtcgga gacgcccgag tcgaagctct gaccgcgccg tggcgccaga gcgtccagct
522841 cgtcgaggaa caccagtgac ggcgcggagt cgcgggcccg ccggaatagc tcgcggactg
522901 ccttctccga ggagcccacc cacttgtcca tcagctccga ccctttgacg gcatgcacgc
522961 tcaactgtcc ggtgctggcc agggcacgaa ccacaaaggt cttgccgcag ccgggcgggc
523021 cgtacagcaa caccccgcgc ggcggttcga cacctagccg agcgaaggtg tcggggtgct
523081 gcagcggcca cagcaccgcc tcggtcagtg cttgtttggc cgcggccatg tcaccgacat
523141 cgtcgagcgt cacgtcaccc acggtgactt cgtcgctggc cgagcgggac agcggccgga
523201 tgacggtcaa cgcaccgagg aggtcgtctt ggtgcagcat cggtggtcgg ccgtcggcac
523261 tggctcgaga cgctgcccgc agcgccgcct cgcgaaccag cgcagccagg tcggccacga
523321 cgaaacccgg tgtgcgggag gcgatttcgt cgaggttgag gtctccggta ggaaccggat
523381 tcagcagcgc ctccagcagc gatttgcggg tggccgcgtc gggcagcggc aggccaagct
523441 cccggtcgca caactcgggg gaacgcagcc gggcatcgag ttgatcgggc cgtgctgagg
523501 tggcgatcaa taccacaccg gcggtggcca ccgcggtacg cagctcggac aggatcagcg
523561 aggctaccgg ctcggcggcg gctggcagca gggcgtcggc atcggtgatc agcaacacac
523621 cgccctcatg gcgaaccgcc tgcactgccg aggccacggc tttgacccgg tctccggcgg
523681 ccagagctcc aatctccgga ccatccagtg tcaccaacct tcggccgtcg cacaccgcgc
523741 gcaccagcgt cgccttgccc accccggccg gacccgacac cagcacaccc aaattggtgc
523801 cggcgcccaa ggtctgtagt aggtgcggct catcgagggc aagcttgagc cattcggtga
523861 gcttggcagc ctgcggctgg gcgcccttga gctcttcgat ctggatctcc ggactcgaga
523921 tgctcacttg cccggccgtg gacgtaccca ttgcggccgg gaccccagcg ccccaggtga
523981 ccagcgagtt gggctgcacg ctgaccggcc cgtcggggtc gacgccggta acggtcagca
524041 gctccgaggt ccaactgatc ccgaccgcag ctgccaatgc gcggctggca gccgacgtgg
524101 atgtgccggg gcctagatcg cggggcagca gcgagaccgc gtcaccgacg gtcatcacct
524161 tgccgagtag ggcctgccgc agcgtgaccg gcggcaccga ctgggtggcc agcgttgaac
524221 cgctcagcgt caccgatcgc gctccgtaga cggtgaccgg gctgacgatc acctcggtgc
524281 cttcgcgaag gcccgcattg gacagtgtga cgtcatcgag cagcaccgtc ccgaccgcgg
524341 tgtctgccgc ggccaggccg gcgaccgcgg cggttgtccg agagccggtc agcgacaccg
524401 cgtcccactc gcggatgcca agggcagcaa tggcattggg gtgcaaccga acgacgccgc
524461 ggcgtgagtc gacggccgag gtgttcagcc gggcggtaag ggtgagttgg cgggccgggt
524521 ccgggtgggt cacagccgtc gacccggctt gcgcaggccc agccgcgcca tcgacggccg
524581 gtagggatgc gcccggcggc tcgcgcgccg caccgcgcgc cgttgcttgg gcttgtcgtc
524641 ccacacctca gggtgttggg caagccagcg ctggctgcgc accgcgaaag gaatatggca
524701 catgtaggcg atgatgatca cccagatcaa caagtagggg gccaggactg cggccgccgc
524761 gcagatagcc agcaccgcca gcagggcggc cgcgtagttg ggtggtaccg acacggcgtg
524821 catctttttc atcgggatcc cgctgaccaa gagtatcgac gttcccgtca cccaaaagct
524881 gaggaaccag cccgaggtcc accatccttc gccgaactgc attttgaggg ctagcaggcc
524941 gatcatggaa accgcgcccg ccggcgcggg cattccgacg aagaattcat gcgcgtaggc
525001 gggctgggtt ccgtcgtcct gcagtgcgtt gtaccgcgcc agccgtaata ccacgcacac
525061 cgcgtagagc agcacgacca cccaaccgac cggccacttc gacaacatcg acacgtaaag
525121 caccagcgcg ggtgtcactc cgaagttcac cgcgtcggcc agtgagtcga tctctgcgcc
525181 catccgcgac tgggcatcca ggatgcgggc cacccggccg tcgagcccgt cgaggatggc
525241 cgctgcggcg atcagtgcca tcgcggcctt cggctggtgc tcgagcgcaa acttgattgc
525301 ggtcagtccc gcgcaaatgg acagcaccgt catcgcgctg ggcagtatct gcaggtttac
525361 ccctcgcctg ccgcggggct ttccgatcat cgacattcgg ccagcacggt ctcgccggcg
525421 accgcgcgct ggccgacgtt gacgatcggc tctgcgcccg ctggcaggta ggtatccagc
525481 cgggagccga accggatcag gccgtaggtg tcaccgatgg ccagcttgtc tccgacgtgt
525541 gcgtcgcaca caatgcggcg cgccaccagc ccggcgatct gcaccgcgac cacctcggcg
525601 ccgttgggca tgcggatccg cacactggtg cgctcgttgt cgtcgctcgc ctccggtagg
525661 tcggccgacc cgaaccggcc cggccggtgt tgcacggcga tcacttcccc gctcaccggg
525721 gcacgttgca cgtgggcgtc caatatcgac aggaagatgc tgactcgcgg taacggcgtg
525781 tcacccatgc tgagttcggc cggtggggcc gctgagtcga tcgcgcagat cacgccgtcg
525841 gcgggcgcga caatggcagc cggcctggtg ggcggtaccc gctgcgggtg ccggaagaag
525901 cccgcgcagg cagcggccgc cagcagaccc gtgccgcgca accaccggta gcggtgtccg
525961 acggccgcaa tcgcaaggcc ggcggcaatg aacggccgcc cggccggatg aaccggtgga
526021 acggcggacc gcaccagggc gagcagatgt tgcgggccgt cggggcgggg gcgtctggcc
526081 acggggtcat cttacggagc ttcgtgccgc aggttgggtg cacggcacta ggatcggtcc
526141 ggttaggtca agtcccagac ttgcagctgc gttccggcag ccacctccac gacgtcctcc
526201 gggatgtcca gaagtccgtt ggccgatgcc aaccaacgca aatggtgcga cgccggtggg
526261 ccgtagctga tgaccgtgcc tgcctggtga tcgagtattg cgcgtcggaa ctgacgtttg
526321 ccgcgcggcg atgtcaggct cgcggtgagt accgcgcttc ggtgcggccg gtacggatcc
526381 ggcaggccca tggccatgcg cagcggggga cggatgaaca cctcgaagga caccagcgcg
526441 ctgaccgggt tgccgggaag ggtgacgatc ggcgtacctg ccacccgccc gacgccctgg
526501 ggcattccgg gttgcatcgc caccttgacg aattcgacac cgtggtcgcc tccccggtag
526561 tcagcgctgc cgaacgcgtc tttgaccacc tcgtaggctc cggcactgac accgccgctg
526621 gtgatgatca ggtcggcgtc caccgcgtac cggtcaagga tcgcgccgaa ctgcgcgacg
526681 tcgtcgccgg cggttgcggt ggcgaccaca gcggcgcccg catcgcggac ggcagcggcc
526741 agcatgatcg agttggactc gtagatctga cccggttgta ggggcgtgcc tggcgacgcc
526801 agctccgacc ctgtggagat caccagcacc cgctgacggg ggagcaccgg cagctcggcc
526861 aaacccagcg cggcggccag gccgagcacc gccggggtca cgatctggcc gttgtgcagc
526921 accgtggtac cggcggcgac gtcttcgccc gaccgtcgga tgtgcttgcc tggggtggcc
526981 tgttggcgga tcgccaccga atcgacgccg ccgtcggtgg cttcgaccgg cacgatcgcc
527041 gtcgcaccgg tgggcactgg cgcaccggtc atgatccggt gcgcagtcac aggctgcagc
527101 gtcagcatgt cggcgcgccc ggcgggaatg tcctcggcga ccggcaacat caccggattt
527161 tgcggtgtgg cacctgaggt gtcttcggcg cgcaccgcat agccatccat tgcggagttg
527221 tcgaaaaccg gcagcgacag cggtgcgacc acgtcgccgc ccaggaccag accttgagcc
527281 tgggtcagcg gaaccgtaat cgggcgacag gcgcgcatca tctccgctac gacacgttga
527341 tgctcctgga ctgaccgcac ccggccatta tcggtcgttc agactccgaa gctgacgccg
527401 gtgagttctt cggagacggt ccagaggcgg cgctgcagat ctttgtcgtg ggactgcgcg
527461 ctggattgga ccaccttcgg gtgaccgcgc tgctcgccga acccgtccgg gccgtagtat
527521 tgcccgccct gcgtggtcgg atcggtggcg gcacgcagtg ttggcagggc gcccatctct
527581 gggctttgga aaagcaacgg cccgagcacg gtagcgacgg gccggataag tcgcggcagg
527641 ttgcgagtca gctcggtgtt ggagccgcca gggtgagcgg cgacggcgat ggtggatttg
527701 cccgcttcgc ccagccggcg ttgcagctcg taggtgaaca gcagattagc cagtttggct
527761 tgtccgtagg cggcgacgcg gttgtaacgg cgttcccact gcaagtcgtc gaagtggatg
527821 gcagcgtgaa tccggtggcc ctggctgctg acggtcacca cccgcgaacc gggtaccggc
527881 agcatgtggt cgagtaccag tccggttagt gcgaaatgac cgagatggtt ggtaccgaac
527941 tgcagctcga aaccgtcctt ggtgacctgc ttcggcgtcc acatcacgcc ggcgttattg
528001 attagcacgt cgatgcgcgg ataggccgtg cgtaacgcgt cggcggctgc gcgcaccgag
528061 tccagcgagc acagatcgag ttgctgcagc gtgacgtggg cgcctgggcg ggcggccatg
528121 atgcgggccc gggcggcgtt gcccttctcg agattgcgga cggccaacac tacgtgtgca
528181 ccgcggtcgg caaacacggc ggcggtgtgg tagccgatgc cggtgttggc gccggtgacc
528241 acaacgacgc gcccgctttg atcggggacg tctgcggccg accatttacg ggtcttgttg
528301 tcgttggcgg tcatgggccg aacatactca cccggatcgg agggccgagg acacggtcga
528361 acgaggggca tgacccggtg cggggcttct tgcactcggc ataggcgagt gctaagaata
528421 acgttggcac tcgcgaccgg tgagtgctag gtcgggacgg tgaggccagg cccgtcgtcg
528481 cagcgagtgg cagcgaggac aacttgagcc gtccgtcgcg ggcactgcgc ccggccagcg
528541 taagtagcgg ggttgccgtc acccggtgac ccccgtttca tccccgatcc ggaggaatca
528601 cttcgcaatg gccaagacaa ttgcgtacga cgaagaggcc cgtcgcggcc tcgagcgggg
528661 cttgaacgcc ctcgccgatg cggtaaaggt gacattgggc cccaagggcc gcaacgtcgt
528721 cctggaaaag aagtggggtg cccccacgat caccaacgat ggtgtgtcca tcgccaagga
528781 gatcgagctg gaggatccgt acgagaagat cggcgccgag ctggtcaaag aggtagccaa
528841 gaagaccgat gacgtcgccg gtgacggcac cacgacggcc accgtgctgg cccaggcgtt
528901 ggttcgcgag ggcctgcgca acgtcgcggc cggcgccaac ccgctcggtc tcaaacgcgg
528961 catcgaaaag gccgtggaga aggtcaccga gaccctgctc aagggcgcca aggaggtcga
529021 gaccaaggag cagattgcgg ccaccgcagc gatttcggcg ggtgaccagt ccatcggtga
529081 cctgatcgcc gaggcgatgg acaaggtggg caacgagggc gtcatcaccg tcgaggagtc
529141 caacaccttt gggctgcagc tcgagctcac cgagggtatg cggttcgaca agggctacat
529201 ctcggggtac ttcgtgaccg acccggagcg tcaggaggcg gtcctggagg acccctacat
529261 cctgctggtc agctccaagg tgtccactgt caaggatctg ctgccgctgc tcgagaaggt
529321 catcggagcc ggtaagccgc tgctgatcat cgccgaggac gtcgagggcg aggcgctgtc
529381 caccctggtc gtcaacaaga tccgcggcac cttcaagtcg gtggcggtca aggctcccgg
529441 cttcggcgac cgccgcaagg cgatgctgca ggatatggcc attctcaccg gtggtcaggt
529501 gatcagcgaa gaggtcggcc tgacgctgga gaacgccgac ctgtcgctgc taggcaaggc
529561 ccgcaaggtc gtggtcacca aggacgagac caccatcgtc gagggcgccg gtgacaccga
529621 cgccatcgcc ggacgagtgg cccagatccg ccaggagatc gagaacagcg actccgacta
529681 cgaccgtgag aagctgcagg agcggctggc caagctggcc ggtggtgtcg cggtgatcaa
529741 ggccggtgcc gccaccgagg tcgaactcaa ggagcgcaag caccgcatcg aggatgcggt
529801 tcgcaatgcc aaggccgccg tcgaggaggg catcgtcgcc ggtgggggtg tgacgctgtt
529861 gcaagcggcc ccgaccctgg acgagctgaa gctcgaaggc gacgaggcga ccggcgccaa
529921 catcgtgaag gtggcgctgg aggccccgct gaagcagatc gccttcaact ccgggctgga
529981 gccgggcgtg gtggccgaga aggtgcgcaa cctgccggct ggccacggac tgaacgctca
530041 gaccggtgtc tacgaggatc tgctcgctgc cggcgttgct gacccggtca aggtgacccg
530101 ttcggcgctg cagaatgcgg cgtccatcgc ggggctgttc ctgaccaccg aggccgtcgt
530161 tgccgacaag ccggaaaagg agaaggcttc cgttcccggt ggcggcgaca tgggtggcat
530221 ggatttctga ccccggcgag aagtcgcagc gaggagcccg gtccctttgt ggggccgggc
530281 tcctctggtt gggagctacg gtaccgagaa caccacgcag tcgtgtaggc aacctttggc
530341 cgctgtgggc gagtcggggg ccgcgtctcg gtgcagcagc gcgcggatgg gtacgacacc
530401 gcagcgggcg gtgtcgtcat cggggcctgc gtccgacgcc tgggcacggc cgtcgacgat
530461 cagcgagtag ccgctaggat cggatggcgg ccacaacagg gtgacttcgc tgcggtgggc
530521 caggttttgc cgcgtacgac ccccgatcag gccgacgtcg accactgccc ggggtccatc
530581 ggggccgtcg gggagttcgc gcagcaccgg ctcgactgcc accgtgtgca cgcgatggcc
530641 atcatcgacg gtgatcaggt aagcgaacgg gtagtcgggc aaggcggcgg ccagccgttt
530701 gaggtctacc tttttggcac ccacggattc gaggataggc gcccgatgtg ttactccgaa
530761 ccgaccggct gcccgatccg cgggctggcg taggcggatt cgcggtcggg gctcgggtag
530821 aagttcgact tggggatgcc ggagccgggg gtactcggct cacgcacggc ggtattccgc
530881 aagcccgagt cgttgctgcc cgagttgacg aagctcgggt agctggtgcc agggcttcta
530941 aggcccgggt ttgcgcccga gccagccgcg gcactgccgc taccggggtt cgggttgcct
531001 gagtccaggc cgccaacagg agcactggcc ggggcggcga cgggcgtgtt ggtcaggccc
531061 gagttgagga cgttcgccag gccgtgttgg agaccgcccg ttgatccgag ggcggaggcg
531121 aggatgcccg aactcaaagc cgccgtgctc atgccgccgg tggcgtagcc ggcggagctg
531181 accaaggccg cctccgagcc agccgcgctt cctaaggcgg cgttttgcat ccccgcgttc
531241 cagaagctgg tgttgaggct gcctgcgctg ccgaggcccg cgttgattgt ccccgaggtc
531301 ccgatgccgc tgttcaggga gcccgaattc ccgatgccga tgtttccgct gccggagttg
531361 aataagccga cgttgccggt gcccgagttc ccgaagccga tgttgccgct acccgagttg
531421 aagccgccga aacccatctg gtgatcaccg gtgatcccga acccgatatt cccgctaccg
531481 gtgttgccga agccgatatt cccgtcgccg aggttgccga ggcccaggtt gccgctgccg
531541 gtgttgccgc tgccgatgtt gccggtgccg gtgttgccgc tgccgatgtt gttgttgccg
531601 atgttgttgt tgccgatgtt gccgctgccg gtgttgccga agcccagatt gatctggccg
531661 ttcttgccga tgtcgatgcc gaggttccgc aagacctgct gccagggcgc cagttgtgcg
531721 acggccgcag acgcatcgaa gtggtaacca gccatcgccg ccacgtccaa tgcccacatt
531781 tgctcgtatg ccgcctcgac gtccatgagc gccggagcat tctgcccaaa ccagttcgta
531841 gctgccagca gctgcatcag gccacgattg gccgctacca ctgccggctg cacggtggcc
531901 gccagcgccg cctcgaacgc ggtcgctatt gccatggcct gtgcggccgc ttgttccgcc
531961 tgcgctgccg ccgtgctgag ccaggctagg tactgggttg cgacggccat catcgccgcc
532021 gcggacggac ccagccaggc gccactagtc agttcggatg tgacggagcc aagcgacgct
532081 attgacgcga gcaattcttc ggccagctcg ccccaggcgg tggccgcagc aattagcggt
532141 cccgacccgg gaccggcaaa catcagtgcc gaattgatct ctggcggcaa ccacgcaaaa
532201 tgcgggcttg tcactgatcc aacttaactg tcagcgaccg ttgccgtggc ggtatcggca
532261 cttcaatacc actcatcttt ggggtcatct ttggagcgcc cctaggaacc gccagcttac
532321 ctagtcccgg gtaggggccg actggcggcc gggatgcagc tgagggtctg ccacctgccc
532381 cgtaatgtcg ctggtatggc aagcaccgac gccgcggccc aagagttgct ccgcgacgcg
532441 ttcacccggt tgatcgaaca tgtcgacgaa ctcaccgacg gcctcaccga ccaactcgcc
532501 tgctaccgcc cgacccccag cgccaacagc attgcgtggc tgctctggca cagcgcccgg
532561 gtgcaggata tacaggtcgc ccatgtggcc ggcgtggaag aggtgtggac ccgcgacggt
532621 tgggtggacc gctttgggtt agatctgccg cggcacgaca ccggatatgg acaccgtccc
532681 gaggatgtgg cgaaggtacg ggcacccgcc gacctgctgt cggggtacta ccacgcggtg
532741 cataaactga ccctggaata catcgctggc atgaccgcag atgagttgtc ccgtgtggtg
532801 gataccagtt ggaatccgcc ggttaccgtc agcgcacggt tggtgagcat cgtcgacgac
532861 tgcgctcagc acctcgggca ggccgcctac ctgcggggga tagcccgata acggcgacat
532921 ccgccggatc gctgaggcga tggtcagcta cgccgaagat cgcctgcacc gatggttacc
532981 tgacgctagc cggcagcgcc gccctagtgg tacccggcgt gttcgtcgcg atgctgggca
533041 ccattgtcgc gccgagactg cggtgagggg ccggggtgtg cgtcctcggc tcacccgagc
533101 ggcagctcgg ccaagatggt accggtgggc tgtggtgatc cggtgccggg ttcgacggtg
533161 aatgccagtg cggtcgaggc tccgagatcg gtcagcgtcg ccgtcgtcga gggcgtcacc
533221 gccgcggtgc ccatcgtccc cgccgacctc ggccctttgg cccctcccag cagccacatc
533281 tgatacacgg ttccccggga tggtggcgcc acattgttca tcaccagcag acctgtgttg
533341 cggtcgcggg agaacaccac cgtggccgtc ccggcgccca gtgggcgaga gaccgtccgt
533401 acgtccggcg ccgtcagaac ttgctcggcc acggtggggg gtggcgatgg ccgggtcagc
533461 acccccaggc cgaacgcccc cagccccaca gcgatcgccg ctgcggacgc aaaggctgcc
533521 gtacgccagc gtgattggcg cctaacctcg ggcttggtcg catccaggat ggccgtccgc
533581 agatgtgctg gcggctcggc ggtggtggcc gccgagacga cggccatcgt ctcgcggacg
533641 gctcgaactt cgtcgttgaa agccgcggct accggcgagg gcgcggcggc cacccgtcgg
533701 tcgatgtcgg ctcgttcatc gtcggacaca gcgttcaggg catacggggt agccagctcg
533761 agcagctcaa aatcggtatg ttcagtcatg agcgccgctc tcccaacgca tcgcttcgct
533821 cggccggcgc agtcatgaca cgtccaggca gttgcgcagg ctgcgcaggg cgtcgcgcat
533881 gcgggatttg atggtcgaca gattggccgc taaccgccgc gaaacttcga catacgtcag
533941 cccgccgtag taggccagtt cgatgcactg ccgctgcgtg tcggtcaacg ccttgaggca
534001 ctcggtcacc cggcgccgct catcaccggc gatcgccagg tcggcgacga cgtcactcgc
534061 gggatcgacg ttggccgcac catagcgcac ttcccgctgg ttgccggctt gctcgcaacg
534121 gactcggtcg acagcgcgcc ggtgggccat ggtcaaaagc caggccaacg cggaaccttt
534181 ggcggagtca aactccgacg cgttccgcca cacctcaaga tagatctcct gggtggtttc
534241 ttcgctgtag ccggtatcac gcagcacccg catcaccagt ccatacaccc gcgacttggt
534301 gtggtcgtag aattcggcga atgcggcctg gtcgtgacca gcgacccggc gcaacagggc
534361 gtccaggtcg ctgctcagcc gtggcggtcc ggtcatcgat gggtagccta tcgccagccg
534421 gcgccgtgat ggtcaagccg gtcatcaccg acgcgccgat cgcggtggcc ggggcacgaa
534481 ataggctgtt cgcctttgat attcggcgaa accggggcga cccttcaggt atctctcagt
534541 cagccgggct ccgctgacgt ccaccagcag gtaggtcatc agcagcggcg aacccaccgt
534601 ggccagcggc gcccagtcgt tgatcgtgat caaccacaac ccccaccaga cacaggcatc
534661 gccgaagtag ttggggtgac gcgtccaggc ccacaggccg cggtccatga tgaccccgcg
534721 attggccggg tcggatttga atacccacag ttgccaatct cccaccgctt cgaaggtgat
534781 accgaccagc cacacggcta agcccacgcc cccaacagcc agtaacggct tcggcgtcgg
534841 cccggtgact gcggaaagct gcagcgggaa tgagacgaac aacgtcagga ggccctgtaa
534901 tccgaagacc ttgcgcaatg cctgcacagg cgtggcaccg cgcagcaggt cggcgtagcg
534961 gggatcctcc ccctgaccgg ctgtcttgcg gtacatgtgc cagctcagcc gcagacccca
535021 ggtcgacacc aacgctagta gcagccatcg gcgaaccggg tcgccgtggc cgagcgtcgc
535081 ggcggcgacg gcgacggcga cgaaacccaa gccccatacc acgtcgacga cgttgtaccg
535141 gccgatgcgg cggccgatcg caaacgccac cgaatgcacc acggccacag ccaaagccga
535201 cacgctggtt accacgacga tgttcacggg gggccctcgc ggatcaacgt ccactggtag
535261 acgtccagat agcccgaccg gaagcccgcc tccgagtacg ccaggtacag ctcccacatc
535321 cgtgcaaaca cctcgtcgaa acctaaatgc gccagcccat ctcgccgctg cataaatcgt
535381 tcccgccaga gccgcagcgt ctcggcgtaa tgcggtcgca gcgaggccgc gtcgacgatg
535441 cgcagcccgg tgtgttgccc ggtgatgtcg atgatggcct gcgtggacgg tagcagtccg
535501 ccagggaaga tgtacttctg gatccaggtc tgggtgtggc gggtggccag cattcggtgg
535561 tgcggcatgg tgatcgcttg aatcgctacc gggccacccg ggcgcaccaa ctgttctagc
535621 gcggcgaagt accgtggcca cgaacggtat cccaccgcct cgatcatctc gactgagact
535681 actgagtcat actgcccgtc gacgtcgcgg tagtcgcaca agtcgatctc tacccggtgg
535741 ccaaagccgg ccgcggcgac ccgctgccga gccagccgtt gctgctccac cgatagggtc
535801 accgagcgga tgtgggcccc ccgtgcggcc gcgcgaatgc acagctcgcc ccatccggtg
535861 ccgatctcga gaacgtggct gccctgctgg accccggcca cgtcgagcag ccggtcgatc
535921 ttgcggcgtt gggctgcggc caactcggtc caggcgggag ttggctgggc cagcaggtcg
535981 gtgaacattg cgcacgaata cgtcatggtc tcgtcgagaa acgcggcgaa caggtcgttc
536041 gacaggtcat agtgcacggc tatattgcgc cgggcctgat ctcggctgtg gtctggccaa
536101 ctaggtcgaa aggtcggcgt gatcggccgc agccagtgca gcgagcgcgg taccagctcg
536161 tccaccgacc ctgccagcac ggtcaacacc cgcgtgagct ccttcgacga ccattcgccg
536221 gccatgtagg actcgccgaa gccgatcaag ccgtggcgcc cgatccggcg tgcaagtgcg
536281 tccggccgat ggatgaacag gctgggtgcg cgcggatcgg cggcacctgt tgccgttccg
536341 tcggagtaga ccaatcgcag cggcaagtga gtggccgtgc gccgaagcag ccggttggcg
536401 attgccgccg atgccgcggc taggggaccg cgcggcacct tggcaaccgc tggccagcga
536461 tccgaatcga ttgctgccga cggtgtctgg ctggtttcga cggtcatcgc ggcaccaccg
536521 gaactcgacg tagccacagt ctgatcccct gtatcctgat gcgcgcggcc accaccatcg
536581 gcgccagcgg tgaaatgatt tgcatcatcg cgatctgtct tgtcgttgcc ggtcgccgct
536641 gcccacgcag ggtggctgtg aattccgggc acacctgccg gcggtcacgg tgcagcgtca
536701 ccgtgacgtc gagttcgcgg tcgggccgtg gtgcccgtat caggtagtag ccggctagct
536761 gatgaaacgg cgaaacgtag aagttcttgg ccgtcaccac gggcaggtcg gccggcggta
536821 gcaggtaagc atggcgtccg ccgtaggtgt tgtgcacctc ggcaatgaca tggcgcagtt
536881 ggccgtcgcg gtcgtggcac cagaagatgc tcaacgggtt gaagacatag ccgagaacgc
536941 gtgcttgcag cagcgcggtg atacggccgt cggggacggc aaggccgcga gcggcaaaga
537001 aggcgtccag ccggtcacgc agcgagctat gcggcggaca cgagaacggg tcagcgaagt
537061 ggtcgtcggc gtggaaccgt gcgaacggtc gcagccacca gggcagctgg gggaggttgt
537121 cgacatccac gtaccagctg tagctgcggt atgcgaacga gtggtgcacc gggacttgtc
537181 tgcagtggct gatcgtggtg cggtagatcg ccggcgtcag ggtttgagtc agcacgcgac
537241 catcgcctcc tgtgggatcg ctgccggcca gtcggcgcca aggcgccggg ccgcccgcag
537301 acccgaggcg gcgccgtcct cgtggaatcc ccagccgtgg taggcgccgg cgaataccac
537361 ccgattgtca cccagcgtcg gcaataagcg ttgggctgca accgattccg gtgtgtacag
537421 cggatggctg taggtcatct cggcgatcac cgagctggga tcaacccggt cgtggccgcc
537481 gagggtgacc agataccggc ggccaccgtc gaggcgcatt agcctgctga tgtcgtagct
537541 gaccacgacc tggtgctgcc cgggtgtcac caggtagttc caggatgcgc gggcgcgatg
537601 gtggcggggc aggaccgact cgtcggtgtg cagctgggcg ctgttggtgg agtatgcgat
537661 cgcgcccagg accgcgcgct cggccggtgt cggctcgtcg agcaacagca gcgcctggtc
537721 gggatggacc gcgacgacgg ccgcatcgaa acgccgcgac ggcccatcac ccgcgcccac
537781 caataccccg tccggcagcc ggcgcagcga gtgcactggc gtgcgggtcg acacctcgtc
537841 cagctgagct gcgatcgcct gcacgtagtt ggcggaacct ccggtgacgg tacgccaggt
537901 tggcgacccg aacaccgaca gcatgccgtg atggtcgagg aagacgaaca gataccgggc
537961 cggatagcgc aaggcgtcgg ccccgccgca ggaccacacg gcggcgacca agggtgtgat
538021 gaagtaatcg acgaaatact gcgagaagtg gtgccggctc aggaaggctt ccagcgtctc
538081 cggtttgtct tccgcgttgt cggtctcctc acgcagcagg cgagccgcgg cgcggtggaa
538141 gcggagaatc tcggcaagca tgcacagata ccgtggccgc agcgattgcc ggcaagcgaa
538201 cagcccgcgc gctcccagtg cgccggcata ttcgagtccg atgtcgtcgg cgcgcaccga
538261 catcgacatt tccgactcct gggtggccac acccagttcg gcgaacaatc ggcacaacgt
538321 tggataggtt cggtcgttgt gcaccaggaa cgccgagtcg acgccgacga cgtcggtgcc
538381 ccgggggccg ccaccgttgt ccagatagtg ggtgtgggca tgaccgccca gccggccgtc
538441 cgcctcgtac agggtgactc ggtcccgtcc agacaggatg taggcggcgg tgaggccggc
538501 gaccccactt ccgacaacag ccaccgatcg tcggagtgat tgctgcacat cctgtattcg
538561 gagcggccgg ctagacggac gggcggttca gccgaggcgg tcgctgctca tcgccaaggg
538621 ccggcccgcg ggctgggttt cgctgggtac ggtcggggtc cgggcgggcc gggaacgcac
538681 ccgcagcggc caccagaacc agcggcccag tagtgcggcg atggatggcg tcatgaacga
538741 tcgcacgatc aacgtgtcga acagcaaacc cagaccgatg gtggtgccca cctgtccgat
538801 aacccgcaga tcgctgacgg ccatggacgc catggtgacg gcgaatacca gccctgcgtt
538861 ggtcacgacc ttgccggtgc cgcccatcga ccggatgatg ccggtcttca gccccgctcc
538921 tatttcctgt ttgaaccggg agaccaagag cagattgtag tcagatccca ccgccaacag
538981 aacgatgacc gacatcgcaa gcacgagcca atgcagatgg attgcgagaa tatgctgcca
539041 gagcagcacc gatagtccga aagaggcacc cagtgaaagt gcgactgtgc ccacaatgac
539101 ggcggcggca ataaaggccc gtgtgatgat cagcatgatg ataaaaatga gacagaggga
539161 cgaaattgcc gcgataagaa ggtcccattg ggcgccctcg gagatgtcgt ggaagacggc
539221 cgccgtgccg gccaggtaga tcttggcgtc ttctagtgga gttcccttga gcgattcctc
539281 ggccgcggta cgaatcgcgt cgatactttt gatgccctcg ggtgattgcg gatcccccct
539341 gtgcaggatg ataaaccggg ccgcgtgtcc gtccgaagac aggaacgact tcatggcgcg
539401 ctggaagtct ttgttcttga aaacctcggg tggaaggtag aacgagtcgt cgttcttggc
539461 ggcgtcaaaa gccttaccca tggctgtggc attgtcgctc atttcgagca tctggtcgaa
539521 gattccggtc atggtgctgt gcatggtaag aatcatggtc cgcatgtttt ccatggcctc
539581 aatctgcggc gggatctgcg cgaccatttg tggcatgagg cgatccatct cgcgcaagtc
539641 gcccaagagg acgcctattt gctcgctgag cttgtcgatt ccgtccagtg catcgaatat
539701 cgatctgaac gaccaacaga tcggaattcc gtagcagtgc ttttcccagt agaaatagct
539761 tcgaattggt ctccagaaat catcaaaatc cgcgacgtgg tcgcgtaatt cttcggtgat
539821 ctccttcatc tcttcggtgt cgccgaccat gcggtgggta gtactggcca tctccgccat
539881 caagctatgc atccgcgtca acaccgcaat cgtcgtggcc atctcgtcgg cctgcttcag
539941 catgtcgttc gcccggtcgc gctggtactt tatggtctgc agctgaccgg cattttgcat
540001 gctgatctgg aacgggatcg acgtgtggtc catcgtcgtt ccttcgggcc gggtaattgc
540061 ttgcacacgg gaaatgcccg ggacccggaa gatgccttta gccagcttgt ccaggaccag
540121 aaaatctgcc ggattccgca tatcgtgatc ggattcaatc attaggatct cgggcttcat
540181 cctggcctga gagaaatgac gatccgcggc cgcatatcct tggttggcgg gtatgaagtc
540241 cggtaggtag tcacggtcgt tgtagctggt tttgtatcca ggcagggcga gcagaccgac
540301 tagggcgatc gcgcaggtgg cgacgagaac gggcagcggc cagcgaacca ccacggtacc
540361 cacccgccgc cagccacgga ctttgaggag ccgcttaggg tcgaacaggc cgaaccggct
540421 gccgacgtgt aggacggccg gacccagcgt caacgcgacc gccactgcga ctagcatccc
540481 caccgcgcag gggatgccca gggtttgaaa gtagggcatg cgggcaaagc tcaggcaaaa
540541 ggtagctccg gcgatggtca atccagagcc cagaatcacg tgggcggtcc cgcggtacat
540601 ggtgtagtag gcggcctctt tgtcctcgcc ggcttggcgg gcttcctggt agcgcccgat
540661 gatgaatatc ccgtagtccg taccggccgc gattgccagc gaagtcagca agctcaccgc
540721 aaaggtggta agtccgatag ccccgctatg ccccagaacc gctacgactc cgcgcgcagc
540781 cgtcaattcg acccccaccg tgatcagcag gagaaccacg gtgattatcg accggtagac
540841 gagcaacaac ataataaaga tcacggcgac cgtaaccatg gtgatcctgg ccatggatct
540901 atcgccactg tggtgcatat ccgcggcgag tgcggatggt ccggtcacat aggcctttat
540961 gcccggcggc gcgggcgtgc tttcgacgat gctgcgtact gcctcgacgg attcgttggc
541021 cagcggcgtg ccttggttgc cggcaagtga cagttgaaca taggcggcct tgccgtcgtt
541081 actttgcacg cccgcggcgg tgagtgggtc cccccataaa tcttggacac tttgcacgtg
541141 cttcttatcg gccctcaatt gagcaaccag gccgtcgtaa tacttatggg cagcgtcgcc
541201 aaggggttgg ttaccctcta ttatgaccat cgcgaaactg tcggaatcgc cttccttgaa
541261 caccatgccg atacgtccca tcgcctcaaa cgacggtgca tccttgggac tcagcgacac
541321 cgatcgctct tggccgacag cttccagtga cgggacaaat acggtgacaa cgacgcaaac
541381 tgccagccag ccaaggatga tcggtaccgc aaaggcgtgg atcatcctgg cgatgaatgg
541441 cttttcgggg cgagcgttgg tattggagtc gttcgcgaat ttagtactca cgcggacttc
541501 accaagcagt aagtataggc gttgacttcg ttggaaaccc tctcggccct gaccttgccg
541561 tctaccgtga ttcggcagcc aatgctgtcg ctattacctt gtgccacgat atttcccatc
541621 accgccgcgt cgtttgtcgt gatatgcaat gaccacggta gcaccgctcc atcgacccgt
541681 tgcggctcgg aattgacgtc gaaataacta atgtcggcga ctgttccggg gggtccgaag
541741 atctcgtaag tcaggtgttt agggttgaat ggtttgctgt tttccaggtt ggtgtcggag
541801 tacgacgggc ggttttcgga gccgaagaag ccgcggatcc ggtgcacggt gaagcccccg
541861 acgatgacca ccaccaggat gaccagtgga atccaagtcc gcattagcac cttgaaaatc
541921 tcagatcccc ttcaccggtt ggcagtggta cggcggacga tacccaactt tcaaaatccg
541981 ttcgagctgg tcgctacttg aacgcaacta agcctagcct aagtaaaaca tggttttagg
542041 cccgagctct cgactcctta cctcgttcgc tggagtgtaa cgcatatcac gtgcgtaacg
542101 gcacgctacg ttatcggcag ccctcttaca aatcacacgg tgtgcgttat cctctggcgg
542161 tggcgcaact cggcttccag cgcgcccgca ccgaggaaaa caagcgccaa cgtgcggcgg
542221 cgctggtgga agccgcgcgg tcgctggcgc tggagacggg cgtggcatcg gtgacgttaa
542281 cggctgtcgc aggtcgtgcc gggattcact actctgcggt gcgccgctac ttcacctcgc
542341 acaaagaagt gctgctgcac ctcgccgccg agggttgggc gcggtggtcg ggcacggtat
542401 gcgagcagct gggcgagccg gggccgatgt cggcaccgcg ggtggccgag gcactggcca
542461 acggtctggc cgccgatccg ctgttttgtg atctgcttgc caatctgcat ctgcatctcg
542521 agcaggaggt ggatgtcgac cgggtcatcg aggtcaagcg gaccagcatc gcagccgtga
542581 tagcgctcgt cgacgcgatc gaaagcgcat tgccggcact cgggcgttct ggggcattcg
542641 acatcctgct ggccgcttac tcgctggcgg ccaccctgtg gcagatcgcc aatccgccgg
542701 agcggctcac cgacgcctat gccgaggagc cagagttgct cccaccggag tggaacctcg
542761 actttgctgc cgcgcttact cgcctgctca ccgctacgct tctcggcctg ctcgccggat
542821 ccccatgcga atgccggtcg ccaacgcgct gaagcgggtg cgggacgaag ggggcgccgg
542881 acttgggccc gcttggcggc ggtaggtgac caaactcacg cttcttgggc gtgcgccgca
542941 gccgaaccac gactattgct agttgcaaac gatagtcata gtcaattgtt gccagacgca
543001 cagctggtgt tggcgggagt cgccgataga ggagtgttcg acatgacgtt gcacgtcggt
543061 gccgacggcc tagagaccgc aactacggcg cgcgccgtgg cggtcgctag gtccggaatg
543121 gattgtgtgg ccggtgatgc gtcaggggcg acttcgtgcc tacgcggtga gctatgacga
543181 gcgcactgat atggatggcc tctccgccgg aggtgcattc ggccttgttg agtagtgggc
543241 cggggccggg gccggtactg gccgccgcca cagggtggtc gtcactgggc cgtgaatacg
543301 ccgcggttgc tgaggaactc ggggcattgc tggctgcggt gcaagccggg gtgtggcagg
543361 ggcccagcgc cgaatcattt gctgccgcgt gcctgccgta tctgtcttgg ttgacgcagg
543421 ccagcgccga ctgcgccgcg gcggctgccc ggctggaggc ggtgaccgcc gcctacgccg
543481 cggctttggt ggccatgccc accctggccg agttggcggc taaccacgcg acccacgggg
543541 ccatggtggc gaccaatttc ttcgggatca acaccatacc gatcgcggtc aacgaggccg
543601 actacgtgcg gatgtggctt caggcggcca ccacgatggc cacctatcaa gcggtcgcgg
543661 actcggcggt gcgctcgatc ccggacagcg tgcctccgcc gcgaattctg aaatccaatg
543721 cccaatccca acactcgagc tcgaataatt ccgggggcgc ggacccggtg gacgacttca
543781 ttgcagagat cttgaagatc atcaccggcg gtcgcgtgat ctgggacccc gaagccggca
543841 ctgtcaacgg cctcccctat gacgcttata ccaaccccgg cacactcatg tggtggattg
543901 ccagaagtct ggaacttctt caagactttc aagagttcgc caagctgctg ttcaccaatc
543961 cggtgaaggc ttttcagttc cttgtcgacc tcatcctgtt cgactggcct acacacatgc
544021 tgcagctggc tacctggctg gccgagaacc cgcagttgct ggtggctgcg ctcaccccag
544081 ccatctccgg actgggagcg gtatcggggt tggccgggtt gaccggccta gtccctcagc
544141 cccccgtcgt gcccgcgccg gcacccgatg cggtcgtgcc caccgtgttg ccactcgccg
544201 ggacggccac gccgactacc gcgccggcca gcgccccggc cgccggagcg gcgcccgggc
544261 ccccggccgg taccgccact gccacatcgg cgtcggtgcc aacgagcgcc ggcggctttc
544321 ccccttacct cgtgggcagc ggtccaggca tcgacttcga cgcggggacg cccgccggtt
544381 ccaggagagc gcagcccgcc gcggataacg tcacggccgt ggcggcagcg caggtgtcgg
544441 cccgtcatca ggcacgtcgg cgccgacgag cggcggcgaa ggaacgtggc aacgccgacg
544501 agttcgtcga tatggactcc ggcccggcga ttccgccgtc gggcgagcgg gacgcttggg
544561 cgtccaattc gggcgtgggc gggctggggt ttgccggcac cgcaagcaac gagacggtgg
544621 cagcgccggc cggattgacc acgctggccg acgatgagtt ccagtgtggc ccacggatgc
544681 cgatgctgcc gggcgcttgg gacttgggaa cttgggaccg cggggactga ttaccctaca
544741 acgcagcgac gtcgcgcatg atgtcggtgg gttcgcgcac cggcgcccca caggtcaggc
544801 agaacgcgcc cggggaacgg gtgagccgac cgacttgaag caggactttg gcctcgacgt
544861 gccacaagca ggcaatgcac agaatttcga cggtgttccc gaatgggtcc aggtcggggt
544921 cgttacattc gtctaccgca tgcagatgca ccacgtaact cgcccggttg gtgcacccgg
544981 ctccggactg gcaggtgatt ccaccccagt ccagggccgc cagcgtgtgt gggatctcgt
545041 tgccgggcgc ttgactcatg cgccgcgctc cagtgtccag gccatgcggc ccacgatgtt
545101 tacctctgcc ccgcaacggc atggtatccc ggcgcgtggc cggtggtggc tgggctacca
545161 agagcgaagt cgggcatggc cttagtccta gtggtacgcg ataggtcgtc gaattccgtg
545221 ggtgatggat atgactattt cgtagctggt cgccagaatc aatccgccga acggcggctg
545281 atgggcccaa cgggctgtcc cccgaatggt ggacaacatt tccgggttcg ttgcaaacga
545341 ccgcgctttg acgccggtta gctttaggcc ggacttaggc ccagttccac accgacatgt
545401 cgccggctgg gtatccattg cacacctcgg tccctttagc gacgacgccc ttgttgttga
545461 agaagatttt catgtgattg acccaggcaa acgtcagcgg atcgccattg taaaagtgtt
545521 cggagtagtc tcggcgctcc gccggtgaca gcgagaagaa ccagtgcgcc ttgttgatcg
545581 tcgcttgctg aaggtttgca tggttgttga agtcgatcat gtaccgctgg tagtacaccg
545641 gactggtatc ccgcaccgcc gccagatatt gttcggcgtc gcaggtggtt gcgatcatcc
545701 ggcgaggtat tggaaagtct tccgtggagt cggctgccgc gctttgtgga aatgtcgcag
545761 cggcgatgcc gagaaccaga aatgccgcgc cggcacgcag gatggaactc agccgagaca
545821 tagtggttac cgtagcactt ttggggcgcc tcgaggcggg cagacgacaa ggttcatagt
545881 ctgtctcact acatgctccc atcaggagtg atgacgtgcg tggggtcggg tcgcagttcc
545941 ggtggggctt ggctgtagtc gccgaacggg ccgtcgcggc gctcgaccgc ggctcgcaca
546001 ccctgggttt gggcggtccg gatgaactcg agcgcgtcgg gggtgttgcg catcagcccg
546061 tcgagaatgc cgcccagcag ctgggtggag gccaggccca tgttctcgta ggcctggttg
546121 acgatcagtt tctgggcttg caactgtgac aacgggattc gtgccagctc ggtggcgatc
546181 tcggcgacgc gagcctcgag ccgctcgaac ggcaccgcct cgttgatcag ctcggcttcg
546241 gcggcctgca caccggtcag cggccggccc gtcagcgagt gccatttgac cttggcaagg
546301 ctgagtcgat acagccacat cccggtcaaa taggctcccc acatgcggct atacggagtc
546361 ccgatcacgg cgtcctcgct ggcgatcaca atgtcggcac acagcgcgta gtcgctggcc
546421 ccgccgacgc accaaccatg cacttgcgcg atcaccggtt tggacgcccg ccagatggcc
546481 atgaatttct gcgtcggtcc ggtctcccgc gcggtgacca tggcgaaatc cttgcccgga
546541 tcccatcggc cgtcggtcat catggcatcg ccccaatgct ggaagccgcc gccgaagtcg
546601 taaccgccgg agaaggcgcg gccggcaccg cgcagcacga tgaccttgat gtcctggtcg
546661 cgctcggcca acccgatagc ggcctcgatc tcgtcgggca tgggcgggac gatggtgttg
546721 agctgttccg ggcggttgag cgtgatggtg gccaccggcc cggccgtcgt gtacagcagc
546781 gtctggaaat cgggtgtcgg catagcagca gcgaagtcac ttcggcccta agggtcaagt
546841 gtctcagcgg ggatcgtgat aacgccgctg gttcgaagct tcggccaacc cgggcgcagg
546901 gtttcgctag ctggcatttg catgcctcgg gcatcggtgt ccggttgcgc tctttgctcc
546961 gacgttagcc gcagggccct gcggctaggc gcggccggtg ccgttggccg cggcggcaat
547021 cgatgttgca gcagttacaa cgccaaatgg agtctgagcg catcgtcgag ttcgatcagc
547081 tcggcagggg agacgttgcg cagcgacgga tccaacctgc tgggcctgcg ccttcgaatc
547141 gacggccagg ccaccgctcg ctgccggcaa caacacctgg aatggggacc ttttcggtgt
547201 tgctggtaac cgggacaacc ggcaccacgc ctcggtcgag acgtatcgcg gcagcgttgg
547261 ccctgtcgtt gctgacaatt accgctggcc gccgcatatt tgccgcgctg ccgcgggccg
547321 gatccaggtc gacctgccag atctcaccgc gcagcatcta cgccgttcgc tgcaaaccgc
547381 cgactgcgac ggcaggccca ctctcttggc atgcgtccaa tgctgcgacg tcctcggtag
547441 acaagctcac gcttggcttc atgccgcagt cctacccatg tagtaacaga tagtaatacg
547501 tagtaatagg tagtaatgca gtatcaatcg gctacaactc gatagccacg ttatttgggc
547561 taagtccacc gttcgtgaat gccggttagc cggccagcat ccgccatagg aacgcgaaac
547621 tcagcgccga tttgaatgcg atctgtgcgt tgtcggctgc gccggcgtgc ccaccctcga
547681 tgttttcgta ataccagacg gggtggcccg cagcctgcag ggccgccgtc attttgcggg
547741 cgtggccggg gtgcacccga tcgtcgcggg tagaggtcgt catgagtact ggcgggtatt
547801 tccggttcgc cgaaatgttt tggtatggcg aatattcaga gatgaacttc cagtcatccg
547861 ggttatccgg atcgccgtat tcggccatcc aggaagcgcc ggccagcagc aggtggtacc
547921 gcttcatgtc cagcagcggc acgtcgcaga ccagcgcgcc gaacttctcc gggtacccgg
547981 tcaacatgat gcccatcagc agcccaccgt tgctgccgcc ccgcgcgccg agctgctcag
548041 cggtggtgat gccgcgggtc accaaatcgg ttgccacggc ggcgaagtct tgggcgacct
548101 tgtcccggcc ctcgcgcatc gcctgcgtgt gccagccagg cccgtactcg ccgccgccgc
548161 ggatgttggc caacgcatag gtgcccccgc gggccagcca cagccggccc aggacgccgt
548221 catacgtcgg cgttctggat gtctcgaatc caccgtagcc gttcaacaat gtggggccgg
548281 gattgtccgc gtcggtgcgt cgcacgacga aatacgggat cgatgtgcca tcgtctgatg
548341 tcgcgaaata ctgtgttaca gccatgtttt ccgcgtcgaa gaaagctggc gcagatttga
548401 tctctgctag tcggccgtca tcggtgccgc gcatcagccg cgacggcgta tcgaatccac
548461 tggagtcgag gaagaactcg tcgccgtggc tgtcggcgga gacgatgacg gtgttggtgg
548521 cggcggggat acctgagagt ggctcacgtc gccagctgcc gggagttgcg atctcgacgc
548581 ggctcgccac gtcggccagg gtgacgatca acagccggtc tcgggtccag gcgtattggt
548641 acagcgcggt gtgctcgtcg ggttcgaaca ccacctgtaa ttccgctgag ccggcaagga
548701 attcgtcgta ttcggcggcc agcagtgagc cggcagtgta cctggtggtg gccacggtcc
548761 agtcggtgcg cagctcgatc aacagccagt cgcggtgaat tgacacgctc gcgtcggtgg
548821 gggcttcgat tcggatcagc tccgaaccac gcaattcgta gacctcttcg ttccagaagt
548881 cgagggcccg tcccagcagg gtgcgctcga atccgggcgt gcgatccgct gacgcgttga
548941 cgcggacgtc ggtgcccgcg ccctcgaaga ttgtctccgc atcggccagc ggtttgcccc
549001 ggcgccatcg cttgatcact cgcggatagc cggaagtggt gagcgagtcg ccgccgaagt
549061 cggtgcccag caagacagtg tccgggtcct cccaggtaat ctgggatttg gccggtggca
549121 gctggaaccc atcctcgacg aattcgcgtg tcagcatgtc gaattcacgc acaatggatg
549181 catccgagcc gcccggggac aggccgatca gcgcgcgcgt gtagtcgggt tcgatgacac
549241 cggcgccgcc ccacacccac ttctggtcgt cggcgcggcc cagttcatca acatcgatca
549301 gcacatccca gcccggcgag tcggtgcggt agctgtccag cgtggtgcgc cgccacaacc
549361 cgcgggggtt ggcggcatcg cgccagaagt tgtagagata gttgccgcgc ctgttcacat
549421 aggggattcg ggcatcggtg tcgagcacct cgagcgcctc gacgcgcatc cgctcgaact
549481 ctgcgtcgca gaacgccgcc gttgtcggct tgttgcgcgc gcgtacccaa tccagcgctt
549541 ccgcaccggt gacgtcctcg agccataggt aggggtcagc gccgtctggg gcaggctcaa
549601 atgtcatgga agccattgtg gccccggcgg tagtgtgagc tgtattacat gattttgacg
549661 aggagccgaa tacgatgact gtcttttccc gtcccggttc cgccggggcg ctgatgtcct
549721 atgaatcccg gtaccaaaac ttcatcgggg gccagtgggt cgcgccggtc catgggcgct
549781 acttcgagaa cccgacgccg gtgaccggcc agccgttctg cgaggtgccg cgctccgacg
549841 cggccgacat cgacaaggcg ctcgacgccg cgcacgcggc ggcgccgggg tggggcaaga
549901 ccgcaccggc cgaacgggcg gcgatcctca acatgattgc cgaccgcatc gacaagaacg
549961 ccgccgcgct ggcggtggcc gaggtctggg acaacgggaa accggtccgg gaagcgctgg
550021 ccgccgatat cccgttggcg gtcgatcact tccggtactt cgccgcggcg attcgcgccc
550081 aggagggcgc gctgagccag atcgacgagg acaccgtggc ctaccacttc cacgagccgc
550141 tcggcgtggt gggccagatc attccgtgga acttccccat cctgatggcg gcctggaagc
550201 tggcgccggc gttggcggcc ggcaacacgg cggtgctcaa acccgccgag cagacacccg
550261 cttcggtgct ctacctgatg tcgctgatcg gtgatctgtt gccgcccggg gtggtcaacg
550321 tggtcaacgg attcggcgcc gaggccggca agccgttggc ctccagcgac cgcatcgcca
550381 aggtcgcgtt caccggggaa accaccacgg ggcggctgat catgcaatac gcctcgcaca
550441 acctgatccc ggtcaccctg gaactcggcg gcaagagccc caacatcttc ttcgccgacg
550501 tgctggccgc ccacgacgac ttctgcgaca aggcgctgga aggcttcacc atgttcgccc
550561 tcaaccaggg cgaggtgtgc acctgcccgt cgcgcagtct gatccaggcc gacatctacg
550621 acgagttcct ggagctggcg gcgatccgga ccaaggcggt ccggcagggc gacccgctgg
550681 acaccgaaac catgctgggt tcccaggcct ccaacgacca gctggaaaag gtgttgtcct
550741 acatcgaaat cggcaagcaa gagggtgcgg tgattatcgc cggaggcgag cgcgccgaac
550801 taggcggcga cctgtccggc ggttattaca tgcagccgac gatcttcacc ggcaccaaca
550861 acatgcggat tttcaaggag gagatcttcg ggccggtggt cgcggtgacg tcgttcaccg
550921 attacgacga cgcgatcggc atcgccaacg acaccctcta cggcttgggt gccggtgtgt
550981 ggagccgcga cggcaacact gcctatcggg ccgggcggga catccaggcc ggccgggtgt
551041 gggtcaactg ctaccacctc taccccgcgc acgcggcgtt cggcggctac aagcagtccg
551101 gcatcggccg ggagggccac cagatgatgc tgcagcacta ccagcacacc aagaacctgc
551161 tggtgtccta ctcggataag gcgctggggt tcttctgatg aacgctcccg cgggggtgct
551221 catcaccgcc gaggccgccg cgctgctggc tgggttacag gaccggcacg gtccggtgat
551281 gttccaccaa tccggcggct gctgcgacgg gtccgcgccg atgtgctacc cgcgggcgga
551341 cttcctggtc ggtgaccgcg acatcttgct gggtgtgttg gacgtcgggg aagacggcgt
551401 gccggtgtgg atttcgggcc cgcagtacca ggcctggaag cacacccagc tgatcatcga
551461 cgtggtgccg ggccgcggtg gcgggttcag tctggaagcg cccgagggcg tgcgctttct
551521 cagcagaggt cgggtgttca gcgacgccga aaaggcgatg cgggaggctg cgccggtgat
551581 caccggcgca gcctacgagt gcggcgaacg accgttagtg cggggtcttg tcgtcgatct
551641 cgacgatcca gatgccacgc cgggagtgtg ccgcgccagt cggcggtagc cgcagtaagg
551701 tcgtagaccg tgatccccct tccgcggtca tggcagctga ccagcgcgat gctggttggt
551761 aatgcgatcg gactgctagc gggggtggcg tgcagcgtgc tggtgcatgc ccggatccgt
551821 ccggacatcg tcatcgcaat ggtagtcggg attcccagcg cgatcgggct gctggtcatc
551881 ctgttctccg gacgtcgatg ggtgacgatg ctgggcgcgt tcatcctggc gttggcgccg
551941 ggttggtttg gtgtgctggt tgcgatccag gtggcgtcca gtggctgaca acgattaccg
552001 gtcggcaccc ggaaccgagc cgtttgtgcc cgatttcgac accggcgcac actcgcagcg
552061 gttcctctcg ttggccggcc agcaggacag ggcggggaaa tcctggccag gctcgacgcc
552121 gaagccgcag gaggaccccg tgggtgtcgc gccttcggcc agcgtcgagg tgctggggtc
552181 cgagccggcc gccacgctag cgcactcggt tacagtaccc ggtcgatata cctacctgaa
552241 gtggtggaag ttcgttctag tggtcctcgg cgtatggatc ggtgctggcg aggtcggcct
552301 gagcttgttc tactggtggt atcacacact cgacaagacg gccgccgtgt tcgtcgtcct
552361 ggtctacgtc gtcgcgtgca ccgtcggtgg cttgatcctg gcgctggtgc cgggcaggcc
552421 actgatcacg gcgttgtccc tcggagtgat gtcggggccg tttgcctcgg tcgccgccgc
552481 ggcgccgctc tacggctact actactgcga gcggatgagt cattgcctgg tcggcgtcat
552541 tccgtactag tcggttgtcg gacttgacct actgggtcag gccgacgagc actcgaccat
552601 tagggtaggg gccgtgaccc actatgacgt cgtcgttctc ggagccggtc ccggcgggta
552661 tgtcgcggcg attcgcgccg cacagctcgg cctgagcact gcaatcgtcg aacccaagta
552721 ctggggcgga gtatgcctca atgtcggctg tatcccatcc aaggcgctgt tgcgcaacgc
552781 cgaactggtc cacatcttca ccaaggacgc caaagcattt ggcatcagcg gcgaggtgac
552841 cttcgactac ggcatcgcct atgaccgcag ccgaaaggta gccgagggca gggtggccgg
552901 tgtgcacttc ctgatgaaga agaacaagat caccgagatc cacgggtacg gcacatttgc
552961 cgacgccaac acgttgttgg ttgatctcaa cgacggcggt acagaatcgg tcacgttcga
553021 caacgccatc atcgcgaccg gcagtagcac ccggctggtt cccggcacct cactgtcggc
553081 caacgtagtc acctacgagg aacagatcct gtcccgagag ctgccgaaat cgatcattat
553141 tgccggagct ggtgccattg gcatggagtt cggctacgtg ctgaagaact acggcgttga
553201 cgtgaccatc gtggaattcc ttccgcgggc gctgcccaac gaggacgccg atgtgtccaa
553261 ggagatcgag aagcagttca aaaagctggg tgtcacgatc ctgaccgcca cgaaggtcga
553321 gtccatcgcc gatggcgggt cgcaggtcac cgtgaccgtc accaaggacg gcgtggcgca
553381 agagcttaag gcggaaaagg tgttgcaggc catcggattt gcgcccaacg tcgaagggta
553441 cgggctggac aaggcaggcg tcgcgctgac cgaccgcaag gctatcggtg tcgacgacta
553501 catgcgtacc aacgtgggcc acatctacgc tatcggcgat gtcaatggat tactgcagct
553561 ggcgcacgtc gccgaggcac aaggcgtggt agccgccgaa accattgccg gtgcagagac
553621 tttgacgctg ggcgaccatc ggatgttgcc gcgcgcgacg ttctgtcagc caaacgttgc
553681 cagcttcggg ctcaccgagc agcaagcccg caacgaaggt tacgacgtgg tggtggccaa
553741 gttcccgttc acggccaacg ccaaggcgca cggcgtgggt gaccccagtg ggttcgtcaa
553801 gctggtggcc gacgccaagc acggcgagct actgggtggg cacctggtcg gccacgacgt
553861 ggccgagctg ctgccggagc tcacgctggc gcagaggtgg gacctgaccg ccagcgagct
553921 ggctcgcaac gtccacaccc acccaacgat gtctgaggcg ctgcaggagt gcttccacgg
553981 cctggttggc cacatgatca atttctgagc ggctcatgac gaggcgcgcg agcactgaca
554041 ccccccagat catcatgggt gccatcggtg gtgtggttac cggctacatc ctctggctgg
554101 cggcgatctc cgtcggcgat ggtctgacga cggtgagtca atggagtcgc gtggtgttat
554161 tgctgtcggt cctggtggcg gtgtgcggcg cggcgggcgg cttgcggctg cgcagccgcg
554221 gcaagctcgc gtggtcggcg tttgctttca gtttgccgat tcctcccgtg gtgctgaccg
554281 tggcggtgct ggccgacatc tacctttgac ggctactgtg ggttgtccgg cgggatggcc
554341 agggcggtga tcgttgcggc gatcgcgtcg tattgggttg cgagtaaaca gaattcgatc
554401 aacaggcgcg gatcgaggtg agttgccagc cgctcccagg tgcccgcggt gatcgtgcga
554461 tccttgatca attcatcggt agcctgtagc agcgcctgtt ggcgggcgct gagcactttt
554521 cgcggtccgt ctccatctgg aacgtcgggc caggcgaata tcgtggcctg ggtgttggcg
554581 tctaggcccc gacggcgcgc cattcggcga tgatgctgaa gttcgtattc gcaagatcgt
554641 aggtgtgcga cccgaaggat caccaactcg gtatcgacgc cgggcagccg cccgtgcagt
554701 agtcggccgg tgtagatggc aaaggtccag aacaagtact ggcggtagcc cagcgtggtg
554761 aacaggtgca tctgcggtgc cccaaccgca cgtgcggcca gcttggccac cagccagttg
554821 accggcccca gctggcggaa cttccccggg gagatacgcg cgacttggcc gttctgaccg
554881 gtcatagttg tttcaccaga tacggggaca ccgtgctgcg gtgttcgtcg agatccagtg
554941 cccgccccaa ggcggggaag gcgcgttgcg gacagttgtc gcgttcgcag acgcggcaac
555001 cggcgccgat aggtgtggcc gcagtattcg ggtcacccga caagtcgagt ccttccgagt
555061 agacgagccg gtgcgcgtgg cgaagttcgc agcccagccc gatcgcgaag gtcttaccgg
555121 gctgaccata ccgggcggcc cggagctcaa cggtgcgggc cacccacagg tagttgcggc
555181 cgtcgggcat ctgggcgatt tgcaccaaga tcttccccgg gttggcaaac gtttcgtaga
555241 cgttccacag cgggcaggtg ccgccgctgg aggagaagtg aaagccggtg gccgactgac
555301 gttttgacat gtttcccgct cggtccaccc ggacgaaggt gaacgggacc ccgcgcatcg
555361 aaggccgttg tagtgtcgac agccggtggg cgatggtctc gtagctcacc gagtagaacg
555421 ccgacagccg ctcgacgtcg tagcggaaat tctcggcgac gtcgtggaac tggcggtagg
555481 gcagcacggt ggccgcggcg aagtaattag ccaggcccag ccgggccaac gtccgcgact
555541 cggcgctggt gaacttgccg tcggtgacca tggcgtcgat gaggtcgccg aactcgagat
555601 aggccaactc ggcggccatc ttgaacacct gctggcccgg ggagaggtga ctgctgatct
555661 ccagcgtgtt ggtcgcgggg tcgtagcggt gcagcacggt gtcaccgagg tcgatgcgct
555721 tgttgatgcg tactccgtgc acctcggtga gccggcgggt caattcgcgg gccaggtcgc
555781 cgtggtgcat ccgcatctgg gccgtgaggt cttcggccgc ggtgtccagc gcatgtagat
555841 agttctggcg ttggtagaag tagtcgcgca cctcttcgtg cggcatggtg atcgaccctc
555901 ggccactgcc gtcggagaac cgctcctcgg tcgcggcggc cagctgcgcg gtggtgatcc
555961 ggtagcgccg atgcaggttg accaccgcgc aggccagccc gggatgagcg ctgaccattt
556021 cggccacttc atgcgggtcg atggcgatgt ctagatcgcg gtccagggtc acctccctga
556081 gttcggcaac cagccgggtg tcgtcctggg aggcaaagaa cgtcgcgtcc accccgaaca
556141 cttcggtgat gcgcagcagc acggccacgg tcagcggccg gacgtcgtgt tcgatctggt
556201 tcagatagct cggcgagatc tccagcatct gggccagcgc ggcctggctg aacccgcgct
556261 cgttacgcag ttggcggacc cgcgagccga cgtaggtctt ggacacccaa ccgagcgtac
556321 cgggtgttgt gaagacgcca ttcgcagagt tagcaagcgt gctgcgattg gtgtttccgc
556381 cacggcgttg gcatgattcg caccgggact caagggtgag cctgaggtac acgcgaggag
556441 gaaatgggga gaacgccgtg agcctcgaca aaaaattgat gcccgtgccc gacggtcacc
556501 ccgacgtgtt cgaccgagaa tggccgctgc gcgtcggcga catcgaccgc gcgggccggc
556561 tgcggctgga cgcggcttgt cggcacatcc aggacatcgg tcaggaccaa ctgcgcgaga
556621 tgggcttcga ggagacccac ccgctgtgga tcgtccgcag gaccatggtg gaccttatcc
556681 ggccgatcga gttcggcgac atgctgcggt gtcggcgctg gtgctcgggc acctccaacc
556741 ggtggtgtga gatgcgagtt cgtgtcgatg gccgcaaggg cggcctgatc gaatccgagg
556801 cgttctggat ccacgtcaac cgggaaaccg agatgccggc ccgcattgcc gacgacttcc
556861 tcgcgggtct gcaccggacc acgtctgttg atcggctgcg ctggaagggc tatctgaagc
556921 cgggcagccg ggatgatgcg tcggagatcc acgagttccc ggtccgggtc accgatatcg
556981 acttgttcga ccacatgaac aacgctgtct attggagtgt gatcgaggac tacctggcgt
557041 cgcatgcaga gctgctgcgg ggccctttgc gggtgaccat cgagcatgag gcgccggttg
557101 cgctcggcga caagctggag atcatctccc acgttcaccc ggctggttcg accgagatat
557161 tcggcccggg gttggtcgac cgcgctgtta caacgctcac atatgtggtt ggcgacgagc
557221 ccaaggcagt cgcctcgctg ttcaatctgt gaccggatcc gcaggacgtc gatccgtggg
557281 tttacctgcg gatttgtcgt tactggcggg tagcttctga aacggttcag tttttgggcg
557341 acttcgcaaa atttgcaaaa agtccgcagg ccgttgccga aattcgcaag tgaaatgggt
557401 ggaccagcgt tgacacgctg tgccatggtc gagttagcac accagtgaag ctgcgccgtt
557461 gacaccgcct ggacgacggt agggcgtcag cgttttcggc aatgaaagac cgttaaggag
557521 ttgtctatgt ctgtcgtcgg caccccgaag agcgcggagc agatccagca ggaatgggac
557581 acgaacccgc gctggaagga cgtcacccgc acctactccg ccgaggacgt cgtcgccctc
557641 cagggcagcg tggtcgagga gcacacgctg gcccgccgcg gtgcggaggt gctgtgggag
557701 cagctgcacg acctcgagtg ggtcaacgcg ctgggcgcgc tgaccggcaa catggccgtc
557761 cagcaggtgc gcgccggcct gaaggccatc tacctgtcgg gctggcaggt cgccggcgat
557821 gccaacctgt ccgggcacac ctaccccgac cagagcctgt atcccgccaa ctcggtgccg
557881 caggtggtcc gccggatcaa caacgcactg cagcgcgccg accagatcgc caagatcgag
557941 ggcgatactt cggtggagaa ctggctggcg ccgattgtcg ccgacggcga ggccggcttt
558001 ggcggcgcgc tcaacgtcta cgagctgcag aaagccctga tcgccgcggg cgttgcgggt
558061 tcgcactggg aggaccagtt ggcctctgag aagaagtgcg gccacctggg cggcaaggtg
558121 ttgatcccga cccagcagca catccgcact ttgacgtctg ctcggctcgc ggccgatgtg
558181 gctgatgttc ccacggtggt gatcgcccgt accgacgccg aggcggccac gctgatcacc
558241 tccgacgtcg acgagcgcga ccagccgttc atcaccggcg agcgcacccg ggaaggcttc
558301 taccgcacca agaacggcat cgagccttgc atcgctcggg cgaaggccta cgccccgttc
558361 gccgacttga tctggatgga gaccggtacc ccggacctcg aggccgcccg gcagttctcc
558421 gaggcggtca aggcggagta cccggaccag atgctggcct acaactgctc gccatcgttc
558481 aactggaaaa agcacctcga cgacgccacc atcgccaagt tccagaagga gctggcagcc
558541 atgggcttca agttccagtt catcacgctg gccggcttcc atgcgctgaa ctactcgatg
558601 ttcgatctgg cctacggcta cgcccagaac cagatgagcg cgtatgtcga actgcaggaa
558661 cgcgagttcg ccgccgaaga acggggctac accgcgacca agcaccagcg cgaggtcggc
558721 gccggctact tcgaccggat tgccaccacc gtggacccga attcgtcgac caccgcgttg
558781 accggttcca ccgaagaggg ccagttccac tagtctgccg agcagacgca aaagcaccct
558841 tttgcggcgc aaaagtggcg cttttgcgtc tgctcgcgca tttgaggagg aacagtgagc
558901 gatgcgatcc agcgggtagg ggttgtcggg gccgggcaga tggggtccgg catcgccgag
558961 gtctcggctc gcgccggcgt cgaagtgacg gtgttcgagc cggccgaggc gttgatcacc
559021 gcgggacgca accgcatcgt gaagtcgctg gagcgggccg tcagcgccgg caaggtaacc
559081 gagcgcgagc gtgaccgcgc cctcggcctg ttgaccttca ccaccgacct caacgaccta
559141 tccgataggc aactggtgat cgaggccgtt gtcgaggacg aggccgtcaa gtccgagatc
559201 ttcgccgagc tcgaccgggt cgtcaccgat ccggacgcgg tgctggcgtc gaatacctcc
559261 agcatcccga tcatgaaggt cgccgcggcc accaagcagc cgcaacgggt tcttggcctg
559321 catttcttca atccggtccc ggtgctgccg ctggtcgagt tggtgcgcac gctggtcacc
559381 gacgaagccg ccgccgcgcg cacggaggag tttgccagta ctgtgctggg caaacaggtc
559441 gtgcgttgct ccgaccgctc cggattcgtg gtcaatgcgc tcctggtgcc gtatttgctg
559501 tcggcgattc ggatggtcga ggccgggttt gccaccgtcg aagatgtcga caaggccgtt
559561 gttgcggggt tatcgcaccc gatgggtccg ctgcggcttt ccgatcttgt cggcctagac
559621 accctcaagc tgatcgcgga caagatgttc gaagaattca aagaaccgca ctacgggccc
559681 cctccgctgt tgctgcgtat ggttgaggcg ggccagttgg gaaagaaatc gggtcgaggt
559741 ttctacacgt actgaagtgt atgaacggcc cccaggcttg acgcaaggcg agatcacaga
559801 ccgagacggt gtggttacga tcgtgtgaca gccgttgcgt acatcgggta gtatttccgc
559861 gatcaacaga tgagaggttc ggccggcatg actgagttaa ggccctttta cgaagagtcg
559921 caatcgattt acgacgtttc cgacgagttt ttctcactgt ttctagaccc cacgatggct
559981 tacacctgcg cgtacttcga gcgtgaggac atgactctcg aagaagcgca aaacgcgaag
560041 ttcgatttgg cgctggacaa gttgcatctt gagcccggga tgacgctgct cgatattggc
560101 tgcggctggg gtggtgggct gcaacgagcg atcgagaact acgatgtgaa cgtcatcggt
560161 atcacgctca gtcgcaatca gttcgagtac agcaaagcga aattggcgaa aattcccacc
560221 gaacgcagcg tccaggtgcg gctgcagggc tgggatgagt tcacggacaa ggtcgaccgt
560281 attgtcagca tcggtgcctt cgaagcattc aaaatggagc gttatgcggc attctttgag
560341 cgttcctacg acatacttcc agatgacggc cggatgctgc tgcacacaat tctgacctat
560401 acgcagaagc agatgcatga gatgggcgtc aaggtgacga tgagcgatgt gcggtttatg
560461 aaattcatcg gcgaagaaat ttttccgggc ggacagttac cggcgcagga agacatcttc
560521 aaatttgcgc aggcggcgga cttttcggtg gagaaggtgc aattgctgca gcagcattac
560581 gctcggacgc taaacatctg ggcggcgaat ctggaggcta acaaggaccg cgccattgct
560641 cttcagtccg aggagattta caacaaatac atgcactatc tgaccggatg tgagcacttc
560701 ttccgcaagg gcatcagcaa cgtgggacag ttcacactga ccaagtagcc catcgccgcc
560761 cgagcacccc aggggttgcg gagctcacgc cgggtgtggc ttgacgcccg ggcaccggcc
560821 ggtgggtagc cagcgcgctt tgtccggtta cttttccagt gtgaactggt cgacgtcggt
560881 gtaaccctgg cggaacagct tcgcgcagcc ggtcaggtac ttcatgtagc ggtcgtagac
560941 agtctgcgac tggatcgcga tggcctgatc tttgttggcc tcgagcgctg tggcccacat
561001 gtccagcgtc ctggcgtagt gcagctgcaa tgactggacc gcggtgaccc ggaagccgac
561061 cttctcggcg tactcgtgca ccgtcgggat ggacggcagc cagccaccgg ggaagatctc
561121 ggccaggatg aatttggtga agtgaaccag ttcgtgggtc aacgtcaggc ccttttccct
561181 gccttctttg aaggtggggc gcacgatggt gtgcagcaac atcttgccgt cggccggcaa
561241 cgtgcggtgg gtcacctcga agaaatggtg gtagcgctgg tggccgaagt gctcgaacgc
561301 gccgatcgag acgatgcggt cgacgggctc gtcaaatttc tcccatccct ccagcaacac
561361 tcgtctggag cggggggtgt ccatttggtc gaacattttc tggacatgac cggcctggtt
561421 ctccgacaac gtcaggccca cgacattgac gtcgtatttc tcgatggcgc gccgcatggt
561481 cgcgccccag ccgcagccga tgtccagcaa cgtcatcccg ggttcgaggt tcagcttgcc
561541 cagggccagg tcgatcttgg cgatctgggc ctcctgcagc gtcatgtcgt cgcgttcgaa
561601 gtaggcacag ctgtaggtct gggtggggtc caagaacagc cggaaaaagt cgtcggagag
561661 gtcgtaatga gcttgcacgt ttccaaaatg cggcgtgagc tgcacggaca taccgattga
561721 gcctttctgt gttccgaggc ccgcatccgc ttgcctcgac gcacccctga tctatccccg
561781 atgcatccct tgcatgctag ctgctgaaag gcggcccagt cgcaatcggc gccatgacca
561841 gctgtcgcag ccgtcagcga aaatcaccag gcgcgccgcc aggcaccgat cgccaggccc
561901 acaaccagca gcgcaccggc ctgacgcacg tgcagccagg ccaacgcggc ataccacagc
561961 ggccacaccg gaaacgccgg tggcggctgc tggggccgcc gtcgcaggaa atagggccac
562021 actttcgcca gccggggcag cgccccggcg accagcaacg cggccagggc atggcagcca
562081 gcatgacgtt tacggcgata agtaggtaga agccgaccat catggccagt gtcacggtgc
562141 gcgcgcacgt ttcgccgagt agcaccggca gcgttcggat acccagcggt tcgtcgtaac
562201 cgatcttgtc gatgtgctta cccatcagca ccgtggtgca caacagcccg taggggagcg
562261 acgccagcac gacctcccaa ccgcccgcgc ccaccgcggc gtagtaggtt ccagcgcacg
562321 ctcgggtgag ccgcagctgg tggttcgtcg aggcgtggta tatgcggcac ggttggcccc
562381 ggtagcggcc gggtgctggg catagcgggc gcgcgcgtag gtggcgctgt cagtaccgac
562441 atcggtgtcg tagagatcgt tcataaggtt gttggcgatg tgcggcgcat gtgattccca
562501 ccacaggacg agccagcgcc aatccaagcc aggctcgccg atcgccaaca gccccgcgac
562561 caggccggag accagggtca tcggcagcac tgcggcccgg gtgacgacga gccaccgggt
562621 gaccgtgtcg gtcggcccgt cagctggcgg gttggtggtg cgaagtgcgt aggcccacga
562681 tctgagccgg gagcccgcgc ccgcgtcggg catccctaaa gcctagacct gcccccaggc
562741 aggcacgatc ggcgaaggat gcggctgctc gcgaaacttc tccaacgatc cgccggcctc
562801 gacgatgccg cacagtgcgc tccagctcag catcgtcagg tagtcgatca gttcgtcact
562861 gctcatgcgc gggtctgaca tccaggagtg ggtggccagc tgcacgccgc ccacgatcag
562921 atatgcccac ggctcgactc cgccggtgtc catcccggct tcttgcatgc ggcggcgcag
562981 catcaccgcg agcatgcggg caatgattcg ctccgagtcg gcaatcactt tgcttttgct
563041 ggccgagcta ttcgccatca cgaaccgata cggctccggt tgggccgcca cggtctcgac
563101 atagacccgg atgatttcgc gggtcagttc gaaaccatcc atatcggccg acagcgcagc
563161 gatcatgttg gggatcaagg tggtctgcgt gaaccgcatc atcacggcgg tcgtcaggtc
563221 gtttttgtcg acgaagtagc ggtagagcac ggtcttggag accccgatct cggccgctat
563281 ctcgtccatg ctgaggaagc ggccatgccg gcgaatcgcc tcaatcgtgc cgtccaccag
563341 ctcattgcgg cgctccacct tgtgctggtg ccagcgtcgc ttgcgaccat ccgtcttcac
563401 ggtcacggcc gggatacgct ctgccactgt tgccaattcc cattcactag acgctcccga
563461 tactacggcc aattgggggt cctgctggca cattggacgc gcgcgcgggg tgcgcaggac
563521 agtgtcgtca cattaactgg tgccggtgat agcggatgat ggtgtggtgg cacatagagc
563581 cgaggtgtcg ggctcgccgc cgccacggct gaatttgagc acccagccga cggtggcgcg
563641 gcgtgtccgc gcctccttcg cggaatcctt cgccgcagcc gatccggagg cggatgccgc
563701 ccggcggatg gcgctgcgtc ggatgaaagt ggtggcagtg gggtttttgg taggcgccac
563761 cggcgtgttc ctcgcttgtc gctgggcaca ggccgatggc gctgaccacg cgtggctggg
563821 ttatctgggc gctgcggcgg aagccggtat ggtcggcgcc ttggcggact ggttcgcggt
563881 gaccgcgctg ttcaagcatc cgctaggcat tccgatcccg catacggcga tcatcaagcg
563941 caagaaggat cagctgggcg agggcctggg caccttcgtg cgggagaatt tcctgtcgcc
564001 gccggtcgtg gagaccaagc tgcgtgatgc gcagataccg agtcggcttg gcaagtggtt
564061 gtcagaggcc acgcatgccc agcgggtggc ggccgagacc gcaacggtgc tgcgggtgct
564121 ggtggagctg ctgcgtgacg aggacatcca gcaggtgatc gaccggatga ttgtgcgtcg
564181 tatcgccgaa ccgcagtggg gtccgccggc gggccgggtg ctggcgacgt tgctggccga
564241 gaatcggcag gaagccttta tccaattgtt ggccgatcgg gcgttccagt ggtcgctcaa
564301 cgccggggtg gtgatccagc gggtggtgga gcgtgactcg ccgagttggt cgccccgatt
564361 catcgaccac ctggttggcg accgtatcca ccgtgagttg atggaattta ccgacaaggt
564421 gcgccgcaac cccgatcacg agttgcgccg ttcggctacc cgcttcttgt tcgatttcgc
564481 tgacgacctg caacacgatc cggccactgt cgcgcgcgcc gacgcgatca aagaggagct
564541 aatggcgcgc gatgagatcg ccactgcggc cgcggcggcg tggaagacac tgaagcggtt
564601 ggtgctcgag ggtgttgacg acccgtccag tgcgttgcgc acccgcatca ccgatgcggt
564661 catccggatc ggcgaatcgc ttcgtgacga tgccgacctg cgtgacaagg tagacagttg
564721 gacggtgcgg gcggcccaac atctggtctc ggagtacggg gtggagatca ccgcgatcat
564781 caccgagacg atcgagcgct gggacgccga ggaagccagc cggcgaatcg aactgcacgt
564841 cggccgagac ctgcagttca ttcggatcaa cggaacagtg gtcggggcga tggcagggtt
564901 ggcgatctat gcgatcgcgc aactgttgtt ctgacgggtg ctaacaaacg cttgcaatag
564961 caagcacttg gacgtactct ggtggccgtt gcaccgatca ccccgagcta ggagtagcca
565021 atgtcgtcgg aggagaagct ggccgccaag gtgtccacca aggcctccga tgtggcttcc
565081 gacatcggca gcttcatcag gtcgcaacgt gagacggcgc acgtctcgat gcggcagctc
565141 gccgagcggt ccggcgtcag caatccgtac ctgagccagg ttgagcgcgg attgcgtaag
565201 ccgtccgccg acgtgttgag ccagatcgca aaggcgctgc gggtctcggc cgaagtcctt
565261 tatgtgcgcg ccgggattct cgagcccagc gagaccagtc aggtgcgtga cgccatcatc
565321 accgatacgg cgatcaccga gcgtcagaag cagattctgc tcgatatcta cgcgtcattt
565381 acccaccaga acgaagccac ccgggaggag tgtccgagcg atccgacacc gaccgatgac
565441 tagccgttgg ccggctgttt tgcgcaccgg ctggcgggta atcaaacctg aaggacagtc
565501 atctgggtga ggtcgaccgc aggctgatcc agccgatcgg ccgcgctggc caacagcgac
565561 tccgtcgatg acgtgcagca aaggagacat gtagtgaccg gatcagctgg gcctgacatc
565621 tacgaactcg accgacaacc gacccgacga tcagaaggtt tccccggcaa gtcgcgtgcc
565681 atgtcaatcc gcgggtcttg actagtcctc cctggaggag ccgacgcttg ccccaacgtc
565741 cagaccaaag atgtaagaac gccgatatca gaaaatagtt aatgaaagga atacccatgg
565801 ctgaaaactc gaacattgat gacatcaagg ctccgttgct tgccgcgctt ggagcggccg
565861 acctggcctt ggccactgtc aacgagttga tcacgaacct gcgtgagcgt gcggaggaga
565921 ctcgtacgga cacccgcagc cgggtcgagg agagccgtgc tcgcctgacc aagctgcagg
565981 aagatctgcc cgagcagctc accgagctgc gtgagaagtt caccgccgag gagctgcgta
566041 aggccgccga gggctacctc gaggccgcga ctagccggta caacgagctg gtcgagcgcg
566101 gtgaggccgc tctagagcgg ctgcgcagcc agcagagctt cgaggaagtg tcggcgcgcg
566161 ccgaaggcta cgtggaccag gcggtggagt tgacccagga ggcgttgggt acggtcgcat
566221 cgcagacccg cgcggtcggt gagcgtgccg ccaagctggt cggcatcgag ctgcctaaga
566281 aggctgctcc ggccaagaag gccgctccgg ccaagaaggc cgctccggcc aagaaggcgg
566341 cggccaagaa ggcgcccgcg aagaaggcgg cggccaagaa ggtcacccag aagtagtcgg
566401 gctccgaatc accatcgact ccgagtcgcc cacggggcga ctcggagtcg acgtgttgga
566461 tgcaaaccgc atagtctgaa tgcgtgagcc acctcgtggg taccgtcatg ctggtattgc
566521 tggtcgccgt cttggtgaca gcggtgtacg cgtttgtgca tgctgcgttg cagcggcccg
566581 atgcctatac cgccgccgac aagctgacca agccggtgtg gttggtgatc ctgggcgcgg
566641 ccgtggcgtt ggcctccatc ctgtatcccg ttttgggtgt gctcgggatg gcgatgtccg
566701 cctgtgcgtc cggcgtgtat ctggtcgacg tgcggcccaa gcttctcgag attcagggca
566761 agtcgcgcta acggaatgaa agccctggtg gccgtgtcgg cggtggccgt cgtcgcactg
566821 ctcggtgtat cttccgccca agctgatccc gaggcggatc ccggcgcagg tgaggccaac
566881 tatggtggcc ccccaagttc cccacgtctt gtcgatcaca ccgaatgggc gcagtgggga
566941 agtctgccca gcctccgggt ctacccgtcc caagttgggc gtacagcctc ccgccgcctc
567001 gggatggccg ctgccgacgc ggcctgggcc gaggttctcg cgctgtcacc ggaggccgac
567061 actgccggca tgcgcgcgca gttcatctgc cactggcagt acgccgaaat cagacaaccc
567121 ggcaaaccca gctggaacct cgagccgtgg cggccggtcg tcgacgactc ggagatgttg
567181 gcttccggct gcaatccggg cagccctgaa gagtcgtttt agtgctcggc caaccgactc
567241 gggcgcagtt ggccgcgctg gtagaccaca ccctgctcaa gcctgagacc acccgtgccg
567301 atgtggccgc gctggtcgcc gaagccgccg aactcggcgt ctacgcggtc tgcgtgtcgc
567361 cgtcgatggt gccagttgcg gtccaagccg gtggtgtgcg ggttgcggcg gtgacgggct
567421 tcccgtcggg caagcacgtg tcctcggtca aggcgcatga ggcggctgcg gccctggcat
567481 ccggcgccag tgagatcgac atggtcatcg acatcggggc tgcgctgtgc ggtgacatcg
567541 acgcagtgcg ctccgacatc gaggcggtgc gtgccgctgc ggccggggct gtgctcaagg
567601 tgatcgtgga gtcggcggtg ctgttgggac agtcaaacgc gcacacgttg gtggatgcgt
567661 gtcgtgccgc cgaggatgcc ggtgccgact tcgtcaaaac ctcgactggg tgtcatccgg
567721 ccggcggggc cacggtgcgt gccgtcgagc tgatggccga gacggtcggc cctcggctag
567781 gggtcaaagc cagcggtggg atccgcaccg ccgccgacgc ggtcgcgatg ctcaacgccg
567841 gtgccaccag gttgggcctg tccggcaccc gggcggtgct cgatgggctc agctgacagc
567901 tgagcgcgcg ggtggcggcg tcaaatgtgc gagaagcagg gattctggat gccggtgggg
567961 atagccgcgt cgcgagttga gaaccggctc accacgccgg tcgaggtgac ttgcacgctg
568021 tccgcgtgaa tccccaacgg gtagttcttg gtcaggctgg aggtgaactc gttcagcgtc
568081 gactgaacgg tttctttcgg cagcgagaac ccgagcgtgt tgaaattgat gatctgcagc
568141 tccaatcctt tgccagccac tatcggcttg gctgtgatgt tgttcagcag gcccttcagt
568201 tcgacggtgc cgtctgcggg gtgagtgacc acgctgctgg tgacgaaagc gcccaggatc
568261 ggaatcgcgt tttgcaccga ttccttgatg ccttccgacg accaggtaat ggtggcgtcc
568321 agggcgccga tcgtgcccct agagttgggg gtgttcttga gccggacgtt ctggatcgtg
568381 agctttatct gcatgccctt ggcatcgcgg atctgattgc ccgcggtttc caccgagata
568441 ttggtgaagt gccgcgtagc gacctgccac agcagcagcg gcgccacacc gaaggatgcg
568501 gtggcttggt ctttgaccac gcatgcgacc gcttgggcga ccttgctatt ggcaacatgg
568561 cgagcgtata gctcgcctcc gatcagcccg gcgaggacga gcgaaaacac gatgatcagg
568621 acaagaaaga cggttagcgg gtcgcggcgg gcacgtcgtt tggtcttcac cgccgctggc
568681 tcttcctctt gcgcagccag caggcccgtt gggtcccacg cctggtgcgc agcttggcgg
568741 ccggatcgcc gtgtgtgggc atgcgacgca gccagatgct cagtttgcgg ctgctgctcc
568801 ggttgggtgg gcggactcac cggttcttgg atatgacccg cgggctcgcc ggggcgcagt
568861 cgaccggtgg atgcttcgga cgatgccggg ggtcgggcga gcggaccttg atccccaggg
568921 cgcgcccagg gcgacgggtc gttcggtgga ccttgcgggt tggtcaccca cgcgattgtg
568981 ccttatcgat ctgaacgaag tctgtctggt tgcgtagcac cgcaatgcgg tcgcgagccg
569041 cggccacatt gtcgacatcg atgtcggcga ccagcagttg cggctgggtg ccagctgaca
569101 ccaccacctc gcctagcggc gaggccacca ggctgccgcc taccccggtc ggtgcagccg
569161 agctcgcccc cacgccggtg cgggcatcac ctgggtctgc ttggccggcc gcggcgacgt
569221 aactcatgga gtctagcgcc cgggcgcggg ccagcaacgt ccactgttcg agtttgcccg
569281 gaccggaacc ccaggatgca cagaccgcga tcagttgggc cccgcgccgc gccagctcgg
569341 tataaagggc gggaaagcga atgtcgtagc aaacggtcaa acccacccgc acgccgtcga
569401 ccacgactac caccggttcg cgcccgggtg cgacggtacg tgactcggtg aagccgaacg
569461 cgtcatagag gtggatcttg tggtagtgcg cgtccggctg attgggcgtg cccgggccgg
569521 ctgcgatcag cgtgtttgtt acccgcccgt cgccggtcgg ggtgaacatg ccggcgatca
569581 cggtgatgcc cgcctcggtc gcgatccgtc ggactccgtt tgcccagggt ccgtcgacgg
569641 gctcggcgac ctgccgcagc gggacaccga gccggcacat ggtcgcctca ggaaacacca
569701 ccagctgtgc gcccgcggtg gcggcttcgc cggcgtactt gccgaccagt tgcagattgg
569761 cggcggggtc ggtaccgctg cggatttgcg ccaacgcgat tcgcatgcgc gccagcctag
569821 gcccggcgac gagcgcgccg caccggcgcg cgcaggagcc gggcaatcca gcttgcgccc
569881 ggcgacgagc gcgccgcacc ggcgcgcgca ggagccgggc aatccagctt gcgcccggcg
569941 acgagcgcgc cgtaccggcg cgcgcaggag ccgggcaagc tggcacctca gacgttgttc
570001 gtgatccaca gcgtggtgaa gcgctgttcg atggtcacta gctggcttaa ttgggtgccg
570061 ataagcctct ccagcttccc gccaatgaac gggatacgca cctggatggt gacctgcagc
570121 gtcattcggg agccacccga ctccggtatg ggcgagagca cggcggtgcc ccacaagttc
570181 accggagcgt ccacgatcga tcccgcaatg gacgcggtcg cgatgccttc cttgaccggg
570241 ccccaggtct cctcgcgccg taccgaaaga tcgccccggt gcaactgtgt gaccaggccg
570301 ggcagattgt gactgcgcac catctgcagg gtgacgactt cgatggtgcc gtcgtctccg
570361 gagtcgccac ctacgcgtat cgactcaagg gtcgcgacgt cgaccggcgt ttcggccagt
570421 ctggctttcc agtagtccgc ctcgtagaaa gcccgatgaa cctcctcgac gctgccctcg
570481 tagtcggccg acatgtcgaa tgaacgcggc atagcaggtc aggctaccct tacgggccat
570541 gaaacggagc ggtgtcggtt cgctctttgc cggtgcgcat attgccgagg cggtcccgtt
570601 ggcgccgctg accactttgc gtgtgggccc gatcgcccga cgtgtcatca cttgcaccag
570661 cgccgaacag gtggtggctg cgctgcggca cctggattcg gcggccaaga ccggagctga
570721 ccgcccgctg gtgtttgctg gtggctccaa tttggtgatc gccgagaacc tgaccgacct
570781 gaccgtggtg cggttggcca atagcggcat caccatcgac ggtaacttgg tgcgggccga
570841 ggccggtgcg gtcttcgatg acgtggtggt tagggccatc gaacagggtc tgggcggact
570901 ggaatgcctg tctggcatcc caggatcggc cggggcgaca cccgtgcaga acgtgggggc
570961 gtatggcgcg gaggtgtctg acaccatcac tcgggttcgg cttttggatc ggtgcacggg
571021 tgaggtgcgt tgggtatccg cgcgcgacct gcgcttcggc tatcgcacga gcgtgctcaa
571081 acacgctgat gggcttgcgg tgcccaccgt ggtcttggag gtggagtttg cgctggatcc
571141 gtcgggccgc agcgcaccgc tgcgctacgg cgagctgatc gccgcgctga atgcgaccag
571201 cggcgagcgc gccgacccgc aagcggtccg cgaagcggtg ctggccctgc gggcacgcaa
571261 gggcatggtg ctggacccga ccgaccatga cacctggagc gtgggatcgt tcttcacaaa
571321 cccggtggtc acccaggatg tttacgaacg gctggccggt gacgcggcca ccagaaagga
571381 cggtccggtc ccgcactatc ccgcgcccga cggcgtcaag ctggccgccg gctggctggt
571441 ggaacgggcc ggcttcggca agggctatcc ggatgccggc gccgccccat gccggctttc
571501 caccaaacat gcgctggcgc tgacaaatcg tggcggggcc accgccgaag atgtggtgac
571561 gctggcgcgc gccgtgcgcg atggggtcca tgatgtgttt ggtatcacac taaaacccga
571621 acccgtgctg atcggctgca tgttgtagct gcgttttcgc ggcggggcgg cgtggcgcgc
571681 attgcttagg gctggttgcc aggcgttctg tggtcattcg tgtgctgttt cgcccggtat
571741 ctttgatacc cgtgaataac tccagcaccc cccagagtca ggggccgatc agtcggcgtc
571801 tggcgttgac ggcccttggg tttggggtgt tggcaccgaa cgttctggtc gcgtgcgccg
571861 gcaaagtgac caagctggcc gagaagaggc cgccaccggc gcctcgtctg actttccggc
571921 ctgccgactc tgccgccgac gtggtgccga tcgcgccgat cagcgtcgag gtcggtgacg
571981 gctggtttca gcgggtcgcg ctgaccaatt cggcaggcaa ggtcgtcgcc ggggcataca
572041 gccgggatcg caccatctac acgatcaccg agccgctggg ctacgacacg acctacacct
572101 ggagcggttc ggccgtcggc catgacggca aggcggttcc ggtggcgggc aagttcacca
572161 ccgtggcacc cgtcaagacg atcaacgcgg gattccagct cgccgacggc cagaccgtcg
572221 ggatcgcggc gccggtgatt attcagttcg attcaccgat cagcgacaag gccgccgtcg
572281 agcgggcact aaccgtgacc accgacccgc ctgtcgaggg cggctgggcc tggctgcccg
572341 acgaggcgca gggcgctcgc gtgcactggc gtcctcggga gtactacccg gcgggtacca
572401 ccgtcgacgt cgacgccaag ctgtatgggc tgccgttcgg cgacggcgcg tacggcgcgc
572461 aggatatgtc gttgcacttc cagatcggtc gtcgtcaggt ggtcaaggcc gaagtctcgt
572521 cgcaccgcat ccaagtcgtc accgatgccg gcgtcatcat ggacttcccg tgcagctacg
572581 gcgaggccga cttggcgcgc aacgtcaccc gcaacggcat ccacgtcgtc accgagaaat
572641 actcggactt ctacatgtcc aacccggccg ccggttacag ccatatccac gaacgttggg
572701 cggtgcggat ttccaacaac ggcgagttca tccatgccaa ccctatgagc gccggtgccc
572761 agggcaacag caatgtcacc aacggctgta tcaacctgtc gacggagaac gccgaacagt
572821 actaccgcag cgcggtctac ggtgacccgg ttgaggtgac cggcagttcg atccagctgt
572881 cctacgccga cggtgacatc tgggactggg cggtggactg ggacacctgg gtgtcgatgt
572941 cggcgctacc gccaccggcg gccaaaccgg cggcgacgca aatcccggtc accgccccgg
573001 tcacgccgtc ggatgccccc accccgtccg gcacacccac gactactaac ggaccgggtg
573061 ggtagcgcga cggctagctg atgcctggtc gcggggccgg atgacgatct ggtcaaggtt
573121 gacgtgtgag ggccgggtgg ccacgaatcc gatcacctcg gcgacgtcgg cggctactag
573181 cggtgtcatg ccggcataaa ccgcgtccgc gcgttgctgg tcgccgtcga agcggaccag
573241 cgaaaattcg gtctcgaccg cacctggagc gatctcggtg agccggaccg gcttccccag
573301 cagttcgccg cgcagcgtgc gatgcagcgc gccctgcgcg tgcttggcag cggtgtagcc
573361 ggcgccgccg tcgtacacct cgatcgcggc gatcgaggtg acggtgacga tcaggccgtc
573421 gccggagtcg atcagcttgg gcagcagcgc gcgggttacc cgcagcgtgc ccagtacgtt
573481 ggtgtcccac atccatcgcc agtgctccaa atcggcatcg gcgacgaact gaagcccctt
573541 ggcgccaccg gcgttgttga ccagcacgtc cacccggctc agcgcgcggg ccaacgcttc
573601 gacggcggcg tcgtcagtga catcggccac aattgcggtt ccgccgatct ggttggccag
573661 cgcggtgatc cggtccgccc gacgcgccac cgcgaccacg tgaaacccct gggccgcaag
573721 ggttctcgcg gttgcctcgc cgataccgga actggcgccg gtgaccacgg cgactcgctt
573781 gcgggtgccg attgtcgtca tcgggacaac tctaataaac gtgctaaatt ctcggtgtgt
573841 accacagcgc cttgttccgc acgacgaccg cgtgtctttt cgcgggcgcg tgttgttgcc
573901 gccccctttg ccgcgcctga ccgatacacg tcagcaggtg tggccaacag gacccggcca
573961 ttggaactcg gagaagaacg cccgtgtact cgactaaccg cacctcacag tcactcagcc
574021 gcaagcccgg ccgcaagcac cagctgcgat cgcaccgtta cgtcatgccg ccgtcgctgc
574081 acctgtccga ttccgcggct gcgtccgtct tccgggccgt gcgtttgcgt ggtccggtcg
574141 gtcgggacgt aattgctgga tctacgtcgc tgagcatcgc gacggtgaac cgccaggtca
574201 tcgcactgct ggaagcgggc ctcctgcgtg agcgggcgga cctggcggtt tccggggcta
574261 tcgggcgccc acgcgtgcct gtcgaagtaa accacgagcc ttttgtcacc ctgggcatcc
574321 acatcggtgc ccggaccacc agcatcgtgg ccaccgacct gttcggccgc acgctcgaca
574381 cggtggagac cccgaccccg cgtaacgctg ccggggccgc gctgacctca ctggccgaca
574441 gcgctgaccg atacttgcag cgctggcgcc ggcgccgtgc gctgtgggtc ggggtgacgc
574501 ttggtggtgc agtcgacagt gccaccggtc atgtcgacca tccgcggctc ggttggcgtc
574561 aggctccggt cggacccgtg ctggcggatg ccctaggcct gcccgtgtcg gtggcgtccc
574621 acgtcgacgc catggccggg gccgagctga tgctcggcat gcggcggttc gcaccgagct
574681 cgtcgacgag cctctacgtc tacgcccgcg aaaccgtagg ctatgcgctg atgatcggtg
574741 ggcgggtgca ctgcccggcc agtggtcccg gcaccatcgc gcccctgccc gtccactctg
574801 aaatgctcgg cggtaccggg cagctggagt ccactgtcag cgacgaggcg gttttggctg
574861 ctgcccgccg gctgcggatc atccccggca tcgcttcgag gacccggacc ggtgggtccg
574921 ctaccgccat caccgacttg ctgcgagtgg cacgagccgg taatcagcaa gccaaggagc
574981 tgctggcgga gcgggcccgc gtgctcggtg gggcggtcgc gctgctgcgt gacttactca
575041 atcccgacga agtggtggtg ggtggccagg cgtttaccga atatcccgag gcgatggagc
575101 aggtggaggc ggcgtttacg gcagggtcgg tgctggcgcc gcgtgacatc cgcgtgaccg
575161 ttttcggcaa ccgggtgcag gaggccgggg caggcatcgt gtccctaagc gggctctatg
575221 ccgatccatt gggtgccttg cggcgatcgg gcgcgctgga tgcccggctg caggacaccg
575281 ccccggaggc gctcgcgtga tcggctgacg agccgcgtcc gcgcgtgtca cttcggttcc
575341 tgcaaggatg gcaggtgtgc ggcacgatga cggttcaggg ttgatcgccc agcgccgtcc
575401 ggtccgcggc gagggtgcca cccgctcgcg cggcccatcc gggccatcca atcggaatgt
575461 ttcggcagca gacgacccgc gccgggttgc gctgctggcg gtgcacacct caccgctggc
575521 acagccgggc accggtgacg ccggcggcat gaacgtctac atgctgcaaa gtgcgctgca
575581 cctggcccgt cggggcatcg aggtggagat cttcacccgg gccaccgcat cggcagatcc
575641 accggtggtg cgggtggcac ccggggtgct ggtgcgcaac gtggtggcgg ggcccttcga
575701 gggtttggac aagtacgacc tgcccaccca gctttgtgcg ttcgccgccg gggtgctgcg
575761 cgccgaggcg gtccacgaac cgggttacta cgacatcgtg cactcgcact actggctgtc
575821 gggtcaggtc ggctggctgg cgcgcgaccg ctgggcggtg ccgttggtgc acaccgcaca
575881 cacgctggcc gccgtgaaga acgcggcact ggccgacggc gacggacccg agccgccgct
575941 gcgtacggtc ggggagcagc aggtcgtcga cgaggcggat cggttgatcg tcaacaccga
576001 cgatgaagcc aggcaagtga tttcgcttca tggtgccgat ccggcacgaa tcgacgtggt
576061 ccatcccggt gtcgatctgg acgtgttccg cccgggtgat cggcgcgcgg cccgggccgc
576121 gctaggacta ccagttgacg agcgcgtggt ggccttcgtc ggacgcatcc agccgctgaa
576181 ggcacccgac attgtgctgc gtgcggccgc caagttgccc ggggtgcgca tcatcgtggc
576241 cggcggaccg tcgggcagcg gtctggcttc accggacgga ctggtccggc tcgccgacga
576301 actgggcatc tctgcacggg tgacgtttct gccgccgcag tcccacacgg atctggccac
576361 cttgtttcgg gcggcggacc tggttgcggt gccgagctac tccgagtcgt tcggcctggt
576421 tgctgtggag gcccaagcgt gcggcacacc ggtggtggcc gcggcggtgg gcgggctgcc
576481 cgtcgcggtg cgcgacggga tcaccggcac cctggtgtcc gggcacgagg tcggtcagtg
576541 ggccgacgcc atcgatcacc tgctgcggtt gtgtgccggg ccacggggac gggtgatgag
576601 ccgggcggcg gcacggcacg ccgccacgtt ctcgtgggag aacaccaccg acgcgctgtt
576661 ggccagttat cggcgtgcga tcggcgagta caacgccgag cgccagcgcc ggggcggcga
576721 ggtgatatcg gacctggtag cggtgggcaa gccccgccac tggacgccgc gtcgcggggt
576781 gggcgcgtga cttcctcctt gccgaccgtg caacgtgtga tccagaatgc gctcgaggtc
576841 agccagctga agtactccca acacccccgc ccgggcgggg cgccgcccgc gctgatcgtc
576901 gagctgccgg gcgaacgcaa gctcaagatc aacaccatcc tgagcgtcgg cgagcattcg
576961 gtgcgtgtcg aggcgttcgt gtgtcgcaag cctgacgaga accgcgaaga cgtataccgg
577021 ttcctgctgc ggcgcaaccg ccgcctgtat ggggtcgcgt acacgctgga caatgtcggc
577081 gacatctacc tggtgggcca gatggcgctg tccgcagtgg acgccgacga ggttgaccgg
577141 gtgttggggc aggtgttaga ggtggtggat tcggacttca atgcgttgtt ggagttggga
577201 tttcggtcgt cgattcaacg agagtggcag tggcggttat ctcgcggtga gtcgctgcag
577261 aacctgcagg ccttcgctca cttacgcccg acgacgatgc agagcgcgca gcgcgatgag
577321 aaggagttgg gcggttaggt cgagcccgac gacgatgcag agcgcgcagc gcgatgagaa
577381 ggagttgggc ggttaggtcg agcccgacga cgatgcagag cgcgcagcgc gatgagaagg
577441 agttgggcgg ttaggtcgag cccgacgacg atgcagagcg cgcagcgcga tgagaaatag
577501 cactcgtgga ggtcaagacg cccgccggtg atgggctggt ggcgctcacc ccgttccgga
577561 ctcagaaatt cgcgatcaca atttgcgcgt tcaagtcatt ggcatgcatg tgatggttta
577621 gcgttccgct gtgcctcttc aggtgtttgt cggcttcgtt gccatgatga cgctcaaggt
577681 cgcgatcggc ccgcaaaacg catttgtcct gcgccaagga attaggcgag aatacgtgct
577741 ggtcattgtg gcgctgtgcg ggatcgctga tggggcactg attgccgcgg gcgttggcgg
577801 cttcgctgcg ctgattcacg ctcatcccaa tatgactttg gttgcccgat ttggcggcgc
577861 agcgttcttg attggctacg cgctattggc cgcgcggaac gcgtggcgcc cgagcgggct
577921 ggtgccgtcg gaatcggggc cggctgcgct gatcggcgtg gtgcaaatgt gcctggtggt
577981 gacctttctc aacccacacg tctatctgga cactgtggtg ttgatcggtg ccctcgccaa
578041 tgaggaatca gatctgcggt ggtttttcgg agccggtgcc tgggccgcca gcgtcgtatg
578101 gttcgccgtg ttgggattta gcgcgggccg gctacagcca ttcttcgcaa ctccagctgc
578161 ttggcgcatt cttgatgcgc tggttgccgt gacgatgatt ggggtcgccg tcgttgtgct
578221 cgtcacgtca ccaagtgtgc cgacggccaa tgtcgcactg atcatttgac cacctcgtag
578281 gccgcccatg tatcggcctt ggtgaaccgg ccgttacggt gccgaccacc tcggcggtat
578341 gaacgcgctg cgcagcggac cgaggagaat tcgggcattt tggtccacga tgaggagtgc
578401 gggagtgcgt gagagacttg ccggtatggc aaacactggc agcctggtgt tgctgcgcca
578461 cggcgagagc gactggaatg ccctcaacct gttcaccggc tgggtcgatg tcggcctgac
578521 ggacaagggc caggcagagg cggttcgaag cggcgagctg atcgcggaac acgacctatt
578581 gcccgacgtg ctctacacct cgttgctgcg gcgcgcgatc accaccgcgc atctggcgtt
578641 ggacagcgcc gatcggctct ggattcccgt gcggcgtagc tggcggctca acgaacgcca
578701 ctacggcgcg ctgcagggtt tggacaaggc cgagaccaag gcccgctatg gcgaagagca
578761 gttcatggcc tggcggcgca gctatgacac gccgccgccg ccgatcgagc ggggcagtca
578821 gttcagccag gacgccgacc ctcgttacgc cgacatcggc ggtggcccgc tcaccgaatg
578881 tctggctgac gtggtcgccc ggtttttgcc atatttcacc gacgtcatcg ttggcgactt
578941 gcgggtcggc aagacggtgc tgatcgttgc ccacggcaac tcgttgcgcg cgctggtcaa
579001 gcacctggac cagatgtctg acgacgaaat cgtcggactg aacatcccga ccggaattcc
579061 gctgcgctac gacctggatt ccgcgatgag gccgctggtg cgcggtggta cgtatctgga
579121 cccggaggcg gcagccgccg gcgccgccgc ggtggccggc cagggccgcg ggtaattgtt
579181 tgagatccca cctgccggcg gtttcggcgg ctgatggtgt gctttggtgc gctgtttgcc
579241 aaacagcatg tgaacggtaa ccgaacagct gtggcgtagt gtgtgacttg tccgattttg
579301 gccttgccgc gctagggcga cgttcaccgg atttgtagga ttttccttgt gactgtgttc
579361 tcggcgctgt tgctggccgg ggttttgtcc gcgctggcac tggccgtcgg tggtgctgtt
579421 ggaatgcggc tgacgtcgcg ggtcgtcgaa cagcgccaac gggtggccac ggagtggtcg
579481 ggaatcacgg tttcgcagat gttgcaatgc attgtcacgc tgatgccgct gggcgccgcg
579541 gtggtggaca cccatcgcga cgttgtctac ctcaacgaac gggccaaaga gctaggtctg
579601 gtgcgcgacc gccagctcga tgatcaggcc tggcgggccg cccggcaggc gctgggtggt
579661 gaagacgtcg agttcgacct gtcgccgcgc aagcggtcgg ccacgggtcg atccgggcta
579721 tcagtgcatg ggcatgcccg gttgctgagc gaggaagacc gccggttcgc cgtggtgttc
579781 gtgcacgacc agtcggatta tgcgcggatg gaggcggcta ggcgtgactt cgtggccaac
579841 gtcagtcacg agctcaagac gcccgtcggt gccatggctc tactcgccga ggcgctgctg
579901 gcgtcggccg acgactccga aaccgttcgg cggttcgccg agaaggtgct cattgaggcc
579961 aaccggctcg gtgacatggt cgccgagttg atcgagctat cccggctaca gggcgccgag
580021 cggctaccca atatgaccga cgtcgacgtc gatacgattg tgtcggaagc gatttcacgc
580081 cataaggtgg cggccgacaa cgccgacatc gaagtccgca ccgacgcgcc cagcaatctg
580141 cgggtgctgg gcgaccaaac tctgctggtt accgcactgg caaacctggt ttccaatgcg
580201 attgcctatt cgccgcgcgg gtcgctggtg tcgatcagcc gtcgccgtcg cggtgccaac
580261 atcgagatcg ccgtcaccga ccggggcatc ggcatcgcgc cggaagacca ggagcgggtc
580321 ttcgaacggt tcttccgggg ggacaaggcg cgctcgcgtg ccaccggagg cagcggactc
580381 gggttggcca tcgtcaaaca cgtcgcggct aatcacgacg gcaccatccg cgtgtggagc
580441 aaaccgggaa ccgggtcaac gttcaccttg gctcttccgg cgttgatcga ggcctatcac
580501 gacgacgagc gacccgagca ggcgcgagag cccgaactgc ggtcaaacag gtcacaacga
580561 gaggaagagc tgagccgatg acctgcgccg acgacgatgc agagcgtagc gatgaggtgg
580621 gggcaccacc cgcttgcggg ggagagtggc gctgatgacc tgcgccgacg acgatgcaga
580681 gcgtagcgat gaggtggggg caccacccgc ttgcggggga gagtggcgct gatgacctgc
580741 gccgacgacg atgcagagcg tagcgatgag gtgggggcac cacccgcttg cgggggagag
580801 tggcgctgat gaccagtgtg ttgattgtgg aggacgagga gtcgctggcc gatccgctgg
580861 cgtttctgct gcgcaaggag ggctttgagg ccacggtggt gaccgatggt ccggcagctc
580921 tcgccgagtt cgaccgggcc ggcgccgaca tcgtcctgct cgatctgatg ctgcctggga
580981 tgtcgggtac cgatgtatgc aagcagttgc gcgctcggtc cagcgttccg gtgatcatgg
581041 tgaccgcccg ggatagcgag atcgacaagg tggtcggcct ggagctgggc gctgacgact
581101 acgtgaccaa gccctattcg gcacgcgagt tgatcgcacg catccgcgcg gtgctgcgcc
581161 gtggcggcga cgacgactcg gagatgagcg atggcgtgct ggagtccggg ccggttcgca
581221 tggatgtgga gcgccatgtc gtctcggtga acggtgacac catcacgctg ccgctcaagg
581281 agttcgacct gctggaatac ctgatgcgca acagcgggcg ggtgttgact cgcggacaac
581341 tgatcgaccg ggtctggggt gcggactacg tgggcgacac caagacgctc gacgtccatg
581401 tcaagcggct gcgctccaag atcgaagccg acccggctaa cccggttcac ttggtgacgg
581461 tgcgcgggct gggctacaaa ctcgagggct agcggacgcc gacaaccttg gcgactgtct
581521 ggtcggctac ggccagtgcc atcgccatga tggacagctg cgggttcact tccgggcagc
581581 tgggcaggat cgaggcgtcg gcaacccaca cgccctcgac gccgcgcagc cggcccgtcg
581641 cgtcgaccgg acaaagctgc tcgtcggcgc cggcggccgc ggtgcccgtc ggatggaagg
581701 cggccaggtg caggcttctg gggttggctc ggcgcagcac atcctgcagc tcgggcaggg
581761 accgcatcgg tggggcgccg gggataccgg tcagcacctc caccgcgccg gcggcaaaga
581821 gcagccggcc aatggcctgc agcgcgaccc gtagcttggc gatctcacct ggagctatgt
581881 catagcgcac caccgtctcg ccgcgcaccg accgcaccgt gccgacgccc cgatcggcca
581941 ccatcgcccc gaatgttgcg atctgcggcg cccggtcgag ccagcggagc agctcggccc
582001 cgtagccggg gaagaccatc gaccccatgc ccggcggtgt ggaggtggcc tcgatcagca
582061 cgccgtcgga ttcgtgaaac tcgtgaaccg ccgcgctctg cagcaccccg cgccacgcga
582121 agacgtcgtc gtcgaagagc ccggccagca tagttgccgg gtgcagcgca aggttgtggc
582181 ccagtcgcgg gtgcccacca agaccgctgc gccgcaacag tcctggcgtc tccgtcgcac
582241 cggcggcgac gacgaccgcg tcggccagca cgtcgagtgt ggtgccgtcg ggccggcggg
582301 ctcgcacgcc ataggcccgc ccggcgcggt gcaggatccg ttcgacccgc gcccaggaga
582361 tgatccgcgc gccggccgcg caggcttgcg gcagggcgtt gaggtgcacg ccgaacttgg
582421 cgttgctggg gcagccgatc gcgcactggc aacagccacg gcaccccggc gcattgcgcg
582481 ggatgggcgc cgcccgccag cccagcgact tggcggcctg cagcaacagg cgcccgttgc
582541 ggcccatgat ctccagcggc accggcgcaa cccgcagtgt ttgctccgca tcgtcaagac
582601 gacgtcccag ctggtcgggg tcggccaggc cgagaccgaa ctcgtcacgc cagcgccgct
582661 gcacggcaag tgaaggccga aagcaggtgc cggagttgac gacggtggtg ccgcccaccg
582721 cccggcccat cggcagcacc accgccggtc gcccgagcgc gacggtggcc ccggcgccac
582781 ggtacaaccc ggcataacgg tcgaccgggt gggtgctacg gaactcctcg accgtccagc
582841 gccgtccctc ttcgagcacg accacgtcaa ggccggcccg ggccagcgtg cgcgcgacca
582901 tcgcgccgcc cgccccggag ccgacgacca ccgcatcggc cctggtgacg gatgggctgt
582961 ccgccgacaa gatgacggtc aactccgcgt cggggcgcgc cgcgtcatgt tcctgggcgc
583021 gggcgagcaa ttcgtgcgcg taggtgtcgg cgccgttggc caacagcacg atcgccttca
583081 acccctccac ggccgcagcg acttccgggc tcagtgcggc gatccggtgc agcacccgtg
583141 cccgctcgtc cgggtgcagt cgcggtagcg accggccggt ggtgaggtag ctggccgccg
583201 ccagtgaagc cagcccggcg cgcaccgcga atcgtgaggt cgccggcagt cgtgtgacgt
583261 agcggtcaac gcgctgcacg aattgagccg gcaacgggcc gccgagctcc ggcggcagca
583321 gcgcggcgcc gaacgaggcc aacggatagg acttagcccg atcggcgagc cggctcatat
583381 ccggcgcccg agccggcggc cgagctttat gaagaacgga tacgttgcga agatggcagc
583441 ggccatcgcg tgcagcggcc actccgcgcg ggccacatcc acgctgaaaa ccccgctgtt
583501 ccacatgaaa tcgcggccgt tctgtgcgcg aaatggccgc cacagcatcc cgagcccggg
583561 tacgttgtgg tacagcccga acgaagcgcc gaagaagacg cccagggcgg cggcctcggc
583621 ggcatcgcgg cggtccacgg gcaggcgtcg ctcgatgagc actccgcaga caaacagcag
583681 cggcgggtcg agcaggaaac tcatgctggc gtcccttcct tgatagccgg tgccgcggtt
583741 ccccgcaggc cgacttcggc gtgtccggtg cccagcaccg accagtgccg gccgccgagc
583801 tcgatgtgga tgtcggcctg ctcggtgttg gtgcacaccg ccttggcccc gtcgggatcg
583861 gtgtatccca ggcttacgca ccgctccggc ggctggtcta cccggattag cgcctcccgg
583921 ccgccgatgc gtccttccag ttgccagtgc cgcacgccga gcgttgtccg cattcgcagc
583981 gacggtaaag gacttgcggg ccaatccttt ccgtcgatgc ggaagcgaac gaacgctagc
584041 ggcgcgagcc tgcgtaggcc cggcttgtgt gataccgcgg tcaccacctc taggacgtcg
584101 ccgtcgccga gatcggcatg gatccatccc caccgcttgg cattgccatg tccgtagatg
584161 tgggccacac tgccgcgcca gctgtcgacg cggtgggtgg tttcgccgac ggccaaggag
584221 ccagcgaaga cggcggtggg tgcgatcacc acttgggcgc cgggcagcaa ctcgcgctcc
584281 caggccacgc gaggaaacgt ccacagtggc gccgcggtgt ccttccagga cagctcccat
584341 gcgagtgatc gggtacgtcc ggtcagctcc gctggcgcca ttcgtacacc ggcgatgtcg
584401 aaccaggcgg ggccggccgc gggttgggcg ggctgggggc cgaagcgctc ggtgcccggc
584461 ggggcatccg gtggaaacca ggtcacccag ccgtgcgcgt agggcccgcc ggtcgtcggg
584521 gccaccgtct cacagtgcac ccataggccg gtacgcgtca gtggatccga cagagtcgca
584581 taccagactt ccaggcgccc ggctgcaccg cgccaccgcg gcaaggccgc cgaccgcgtt
584641 tcatcgtcca ctgcggcacc tcctgctggc tgagttgtcg attcgcccac tatattggtt
584701 gagccaatga accagtcaag tgtctttcag ccgccggatc ggcagcgggt ggatgagcgg
584761 atcgcgacga cgatcgccga cgccatcctc gacggcgtct tcccgccggg ctcgaccctg
584821 ccgcccgagc gagacctggc agagcggctc ggtgtcaacc gcacctcgct acgccagggt
584881 ctggcgcgac tgcaacagat gggcctgatc gaggtgcggc acggcagcgg cagtgtggtc
584941 cgtgaccccg aggggctcac ccatcccgcg gtggtcgagg cgctggtgcg caaactgggc
585001 cccgacttcc tcgtcgagtt gctggagatc cgcgcggcgt taggcccgtt gattggccgc
585061 ctggcggccg cccggagcac gcccgaggat gccgaggcgt tgtgtgcggc gctggaagtg
585121 gtgcaacagg cggacacggc cgcggcgcgg caggcagccg atcttgccta cttccgggtg
585181 ctcatccaca gcactcgcaa ccgcgcattg gggttgctct accgctgggt ggagcacgcc
585241 ttcggcggcc gcgagcatgc gctcaccggg gcctacgacg acgcggaccc agtgttgacc
585301 gacctgcggg cgatcaacgg ggcggtgctg gccggtgacc cggcggccgc tgccgcgacc
585361 gtcgaggcgt atctgaacgc cagtgcgctg cgcatggtca agtcctaccg cgaccgcgct
585421 tagctactgg gccgcacgcg tcgccggatg tacggcgatg agccctaatt gactgcggcg
585481 cttgcacatt gctgcgagtt ccccataggc cttctccccg agtaattcgg tgagttcgtc
585541 ggcaaggctc tgccacacct gcttggttcc gacatgggcg gccggatcgc cggtgcaata
585601 ccagtgcagg tcagcaccac ccgagcccca accgcggcgg tcatattcgg tgagggtggt
585661 cttgaggatt tcggtgccgt cggggcgggt cacccattcc tggctgcgcc ggatcggcaa
585721 ctgccagcag acatcgggtt tcatcgtcaa cggcggcacg cccagcttga gggctttgct
585781 gtgcagcgcg cagccggcgc caccggcgaa cccgggccgg ttcaagaaga tacacgcgcc
585841 cttgtgtttg cgggtgcggt gctggggttg gccgtcgtgc tcgtcgagtt ccaggtagcc
585901 cttgcggcgc aggccctttg cccggaactg ccagtcgtcg tcggtcagct tgtgcaccgc
585961 gtcggccaac cgggtgcggt cgtcgtcgtc ggacaggaac gcaccgtgcg aacaacagcc
586021 gtcgtttggc cggcccgcga cggtgccctg gcaggcgggt gtgccgaata cacacgccca
586081 gcgcgacagc aaccaggtaa ggtcggccgc gatcaggtgc tcgggattgt ccgggtcgta
586141 gaactccacc cactcacggg cgaagtccaa ctcgacttct tgccccgggt gcaccggtct
586201 ccgtcgcgaa tttgccacgg attcaacgtt agaccacgaa gcccgccgcg ggattccgcc
586261 atagcccagc acggccggca catgccaccg ggcgccttgc gcgggtcgcc acacgcccgt
586321 atcttcgccc ggctagtttg ttttcgtgcg attgggcgtg ctggacgtgg gtagcaacac
586381 ggtccatctg ctggtggtcg atgcccaccg cggcggccac ccgaccccga tgagctcgac
586441 gaaggccacg ctgcggctgg ccgaggccac cgacagctcg ggcaagatca ccaagcgcgg
586501 agccgacaag ctgatttcca ccatcgacga attcgccaag attgccatca gctcgggctg
586561 tgccgagctg atggccttcg ccacgtcggc ggtccgcgac gccgagaatt ccgaggacgt
586621 cctgtcccgg gtgcgcaaag agaccggtgt cgagttgcag gcgctgcgtg gggaggacga
586681 gtcacggctg accttcctgg ccgtgcgacg atggtacggg tggagcgctg ggcgcatcct
586741 caacctcgac atcggcggcg gctcgctgga agtgtccagt ggcgtggacg aggagcccga
586801 gattgcgtta tcgctgcccc tgggcgccgg acggttgacc cgagagtggc tgcccgacga
586861 tccgccgggc cggcgccggg tggcgatgct gcgagactgg ctggatgccg agctggccga
586921 gcccagtgtg accgtcctgg aagccggcag ccccgacctg gcggtcgcaa cgtcgaagac
586981 gtttcgctcg ttggcgcgac taaccggtgc ggccccatcc atggccgggc cgcgggtgaa
587041 gaggacccta acggcaaatg gtctgcggca actcatcgcg tttatctcta ggatgacggc
587101 ggttgaccgt gcagaactgg aaggggtaag cgccgaccga gcgccgcaga ttgtggccgg
587161 cgccctggtg gcagaggcga gcatgcgagc actgtcgata gaagcggtgg aaatctgccc
587221 gtgggcgctg cgggaaggtc tcatcttgcg caaactcgac agcgaagccg acggaaccgc
587281 cctcatcgag tcttcgtctg tgcacacttc ggtgcgtgcc gtcggaggtc agccagctga
587341 tcggaacgcg gccaaccgat cgagaggcag caaaccatga cgggaccaca ccccgaaaca
587401 gagagctccg gtaaccggca gatctcggtg gccgagttgc tggccaggca aggggtcacc
587461 ggcgccccgg cccgacggcg ccggcggcga cgcggcgata gtgacgccat cacggtcgcc
587521 gagctgaccg gtgagattcc gatcattcgt gacgaccatc accacgccgg cccggacgcg
587581 cacgcgagcc agtctccggc ggctaacggg cgagtccagg ttggcgaagc tgccccacag
587641 tcgccggcgg aaccagtcgc cgagcaggtt gccgaagagc caacgagaac cgtgtactgg
587701 tcgcaacccg agccgcgctg gcccaagtcc cccccgcagg accggcgcga gtccgggccc
587761 gagcttagcg agtacccgcg gccactgcgc cacacgcata gcgacagagc acccgcgggg
587821 ccgccgtccg gtgccgaaca catgagtccg gatccggtcg agcactaccc cgatctctgg
587881 gtggatgtcc tggacaccga ggtgggcgaa gcggaagccg agaccgaggt gcgcgaagcg
587941 caacctgggc gcggcgagcg ccacgccgca gcggcggcgg ccggcaccga cgtcgagggt
588001 gatggtgcgg ccgaggcgcg ggttgcccgt cgtgccctgg acgtggtccc gacgctgtgg
588061 cgcggcgcgt tggtcgtgct gcagtcgatc ctggccgttg ccttcggtgc cgggttgttc
588121 atcgccttcg accagttgtg gcgctggaac agcatagtgg cgctagtgct atcggtgatg
588181 gtcatccttg gcctagtggt ctcggtgcgg gcagtccgca agaccgaaga catcgccagt
588241 acgttgatcg cggttgcggt gggggcgctg attaccctgg gaccgctggc cttgttgcaa
588301 tcgggctagc cgccaccaca cacagtgcgc ccagcaatca aagtcggctt gtcgacggcc
588361 tcggtgtacc cgttgcgggc cgaggccgcg ttcgagtacg ccgacaggct tggctacgac
588421 ggggtcgagc tgatggtctg gggtgaatcg gtcagtcagg acatcgatgc cgtccggaag
588481 ctgtcgcgcc gctaccgcgt gccggtgttg tcggtgcacg ctccgtgcct actcatctcg
588541 cagcgggtgt ggggcgccaa tccgatcctc aagttggacc gcagtgtgcg ggccgccgaa
588601 caactgggcg cgcaaacggt cgtcgtgcat ccgcctttcc gctggcaacg acgctacgcc
588661 gaagggttca gcgatcaggt tgccgcccta gaagcggcca gcaccgtgat ggtggccgtt
588721 gaaaacatgt ttcccttccg agcggaccgg tttttcgggg ccggccagtc ccgggaacgg
588781 atgcgtaagc ggggtggtgg cccaggtccg gcgatctcgg cgttcgcgcc gtcctacgac
588841 ccgctggacg gcaaccacgc gcattacacg ctggacctct cgcacaccgc gactgcgggc
588901 accgactcgc tggatatggc gcggcggatg ggcccagggc tggtgcacct gcacctgtgt
588961 gacggcagcg gcctgcccgc cgacgagcac ctggtgcccg gccgcggtac ccagccgacc
589021 gccgaggtgt gccagatgct ggccggcagc ggcttcgtcg gccacgtcgt gttggaggtg
589081 tccacctcaa gcgcgcgttc ggccaatgaa cgcgaatcca tgctggccga gtcgttgcag
589141 ttcgcccgca ctcacctgct gcgttgatat gccgggaaca ctatgaacgc gttgttcacc
589201 acggcgatgg cgctgcgccc gcttgactcc gatcccggca atccggcgtg ccgggttttt
589261 gaaggcgagc tgaacgagca ctggaccatc gggcccaagg tgcacggcgg tgcgatggtg
589321 gcgctgtgtg ccaatgccgc ccgcaccgct tacggcgcgg ccggacagca gcccatgcgg
589381 caaccggtcg cagtgtcggc gagctttctg tgggcgccgg atccggggac gatgcggttg
589441 gtgacgtcga tccgcaagcg tggtcgccgg attagcgtgg ccgatgtcga gctcacccag
589501 ggtggccgca cagcggtgca cgccgtggtc accctgggtg agccggagca ttttctcccc
589561 ggcgttgatg ggagcggcgg ggccagtgga accgcgccgc tgctgtcggc gaatccggtg
589621 gtggagctga tggcaccgga accgcccgag ggagtcgtgc cgatcggtcc cggccatcag
589681 ctggccgggc tggtgcactt aggcgaaggc tgcgatgtcc ggccggtgtt gtcgacgttg
589741 cggtccgcga ccgatgggcg gccaccggtg attcagctgt gggcgcgtcc acgcggcgtt
589801 gctccggacg cgctgttcgc tctgttgtgc ggggacttgt cggccccggt gaccttcgcg
589861 gtggaccgca ccggctgggc gcctacagtt gcgctcaccg cctatcttcg ggccctgccc
589921 gccgacggct ggctgcgagt gctctgcacc tgcgtcgaaa tcgggcagga ctggtttgac
589981 gaggaccaca tcgtcgtcga ccggttgggc cgcatcgtgg tgcagacgcg ccaactggcg
590041 atggtgcctg cccagtagca cggatcggcc gagctgtctg cgatgctttt cggcatggca
590101 aggatcgcga ttatcggcgg cggcagcatc ggtgaggcat tgctgtcggg tctgctgcgg
590161 gcgggccggc aggtcaaaga cctggtagtg gccgagcgga tgcccgatcg cgccaactac
590221 ctggcgcaga cctattcggt gttggtgacg tcggcggccg acgcggtgga gaacgcgacg
590281 ttcgtcgtcg tcgcggtcaa accagccgac gtcgagccgg tgatcgcgga tctggcgaac
590341 gcgactgcgg cggccgaaaa cgacagtgct gagcaggtgt tcgtcaccgt ggtagcgggc
590401 atcacgatcg cgtatttcga atccaagcta ccggctggga cgccagtggt gcgtgcgatg
590461 ccgaacgcgg cggcattggt gggagcgggg gttacagcgc tggccaaagg ccgctttgtc
590521 accccgcaac agcttgagga ggtctcggcc ttgttcgacg cggtcggcgg cgtgctgacc
590581 gttccggaat cgcagttgga cgcggtgacc gcggtgtccg gctcgggtcc ggcctatttc
590641 tttctgctgg tcgaggccct ggtggatgcc ggagtcgggg tgggcttgag ccgtcaggtg
590701 gccaccgatc tcgccgcgca gacaatggct ggctcagcgg cgatgctgct ggagcggatg
590761 gagcaagacc agggtggcgc caatggcgag ctgatggggc tgcgcgtgga ccttaccgca
590821 tcacggctgc gcgccgcggt tacctcgccg ggcggtacga ccgccgctgc gctgcgggaa
590881 ctcgaacgcg gcgggtttcg gatggctgtc gacgcggcgg ttcaagccgc caaaagccgc
590941 tctgagcagc tcagaattac accggaatga ttcacgaatt ttgaactgat tatccctcac
591001 cagtaccagt aaccccacta gtcccgctat tctcctcttt gtaagcgcgt gtgggtgcca
591061 gcggagggga agccgctggg actgcgcgtg cctgacacga ttgggttgcg atgacgtcta
591121 cgaacgggcc atcggcgcgg gataccggtt ttgttgaggg ccagcaggcc aagacacaac
591181 ttctcaccgt ggccgaagtg gcggccctga tgcgggtgtc caagatgacg gtgtaccggc
591241 tggtgcacaa tggcgaactg cccgcggttc gggtcgggcg gtcattccgg gtgcatgcca
591301 aggccgtcca cgacatgttg gagacttcgt acttcgacgc gggctagttg ccggccgcac
591361 gcggccggag tccgcctgac cgatctggca atgctcgggc gctgccggtt tggtgttccg
591421 tgcgaccgcc cgggtagagt gtccgggtca gatagccgta tagatggcgg ggtcatgggt
591481 tcagtaatca agaagcggcg caagcgcatg tccaagaaaa agcatcgcaa gctgctgcgt
591541 cgcacccggg tgcagcgcag gaaactgggc aaataggttg cgagcagacc ccgccagctc
591601 gaccgtcacg cgcttgtaac gccgccgttt cgcctggccg ttaggctgtc ggagtgagtt
591661 cgtcgaacgg gcgcggtggc gccggaggag tcggcggcag cagtgagcac ccgcagtacc
591721 ccaaagttgt gctggtgacc ggtgcttgcc gtttcctagg cggctacctg accgcacggc
591781 ttgcccagaa cccgctgatc aaccgggtca tcgcggtgga cgcgatcgcg ccgagcaagg
591841 acatgctgcg ccggatgggc cgagccgaat ttgttcgcgc tgatatccga aacccattca
591901 tcgccaaggt gattcgcaat ggcgaggtgg acacggtggt gcacgccgcg gcggcctcgt
591961 atgcgccgcg gtccggcggc agtgcggcat tgaaggaact taacgtgatg ggcgcgatgc
592021 aactgttcgc cgcctgccaa aaggcgccct cggtccgccg ggtcgtgctg aagtcgacct
592081 ctgaggttta cggatcgagc ccacacgatc cggtgatgtt caccgaggac agcagcagtc
592141 gacgtccttt cagccaaggt ttccctaagg acagtctcga tatcgagggc tacgtgcgcg
592201 cgctgggccg acgccgcccc gatattgcag tgactatcct gcggctggcc aacatgatcg
592261 gcccggcgat ggacaccacg ctttcacgat atctggccgg gccgctggtc ccgacgatct
592321 tcggccgtga tgcgcgactg cagttgctgc acgagcagga tgcgctgggt gcgttggagc
592381 gcgcggcgat ggccggcaag gccggaacgt tcaacatcgg agccgacggc atcctcatgc
592441 tgtcgcaggc gatccggcgg gccgggcgaa ttccggtgcc ggtgccaggg tttggggtat
592501 gggctctgga ttcgctgagg cgagcgaatc actacaccga gctgaatcgt gagcaattcg
592561 cttacctgag ttatggccgg gttatggaca ccaccagaat gcgcgtcgaa ctgggttacc
592621 agccgaagtg gacgaccgtc gaggcgttcg atgactattt tcgcggccgc ggcctgactc
592681 ccattattga cccacatcgg gtacgctcct gggagggtcg cgccgtaggt ttagcgcagc
592741 gctggggtag ccgaaatcca attccatgga gcggactcag ataggtttgg atgggtaacg
592801 tggcgggcga aaccagagcg aatgtcattc cactgcacac aaatcggagc cgggtagcgg
592861 cgcgcaggcg tgccggtcaa cgggcagagt cccggcagca tccgtcgttg ctgtccgatc
592921 caaatgaccg ggcgtcggcc gagcagatcg ccgccgttgt ccgggaaatc gacgaacacc
592981 ggcgcgctgc gggtgccacg acctcgtcca ccgaggccac gcccaacgac cttgcgcaac
593041 tcgtcgccgc ggttgctgga tttctccgac agcgcctgac cggtgactac agcgtcgacg
593101 aattcgggtt cgacccgcac ttcaacagcg ccatcgtacg acccttgctg cgattcttct
593161 tcaagtcatg gtttcgggtc gaagtcagtg gtgtcgagaa catcccgcgc gatggtgcgg
593221 cgctggtggt ggccaatcac gcaggtgtgt tgccgtttga cgggttgatg ttgtcggtgg
593281 ccgtccacga cgagcacccg gcgcatcggg atctgcggct gcttgccgcc gacatggtgt
593341 tcgacctccc cgtgatcggc gaagccgccc gcaaggcggg tcataccatg gcgtgtacga
593401 cggatgcgca ccggttgctt gcctccggcg aactcaccgc ggtgttcccc gagggataca
593461 aggggctggg taagcgtttc gaggaccgtt accggttaca gcggtttggt cgcggcggct
593521 tcgtatcggc cgcgctacgg accaaggcgc cgattgtgcc gtgttcgatc atcggctccg
593581 aagagatcta ccccatgctg accgatgtca agctgctggc tcggctgttc ggcctgccgt
593641 acttcccgat tacgccgttg ttcccgttgg ctggaccggt cgggctagtg ccgttgccct
593701 cgaaatggcg catcgcgttc ggtgagccga tctgcaccgc cgactacgcc tccaccgacg
593761 ccgacgaccc gatggtgacg ttcgagttga ccgatcaggt gcgcgagacg atccagcaga
593821 cgctataccg actgcttgcc ggccgtcgca acatcttttt cggctgaccc ttatttgacc
593881 agagtgaact ggcagacgtc cgtgtacttg tcgcggaaca ggtctgagca gccacgtagg
593941 tagtgcatgt agatgtcgta cgtctcctgg cccttgaggg cgatcgcctc atctttgtgc
594001 gcctgtagcg catccgccca ggcgttcagg gtcggcacgt agttggcccc gatccggtgg
594061 tagcgctcga ccttccatcc ggcgttggag gagtaatagt ccacctgcga gatcctgggc
594121 agccgcccgc ccgggaagat ctcggtcagg atgaacttga tgaagcgcag caggctcatc
594181 ggagacgtca agcccagctc ctgggcttcc tctttgtccg ggatagtgat ggtgtgcagc
594241 agcatccggc cgtcgtcggg cgtcaaattg tagaacttct tgaagaaggt gtcgtagcgc
594301 tcgaacccgg cgtccccggc accgtcggcg aaatgctcaa acgcaccgag tgacacgatg
594361 cggtcgaccg gctcgtcgaa ctcctcccag ccctggattc gcacctcttt tcggcggggg
594421 ctgtcgacct catcgaacat cgccttgtcg tgggcgtact ggttttcgct cagggtcaag
594481 ccgatgacgt tgacgtcgta ctcggcgacc gcgtgtcgca tggtggaacc ccagccgcag
594541 ccgatgtcga gcagcgtcat gccgggctca aggttcagct tgtccagtgc cagcttgcgc
594601 ttcgcgtact gcgcctcttc cagcgtcata tcgggacgtt cgaagtaggc gcagctgtac
594661 gtcatcgatg ggtcaagcca gagcttgaag aactcgttcg atttgtcgta gtgggatcga
594721 actgcttcga ccggcggctt gagctgcgtg ccgcttgtcg tgtcgccctg tgacgtcatt
594781 gaacggaccc tactttcccc actagatcga tgcaatcgcc gccaccgttg catcggcatc
594841 ggcttcgtgg tgggccgctt ctcccaacat ggtgacgaca ctggtgacca caggctttcc
594901 ttcggcgtcg gtaacttcgc ttcggatctc ggcgagcacc gtgccgtggg attcgatgac
594961 ggagtcaaga taggtgtcga agtacagctt gtcgttggcc aggatcggcc ggtggaagcg
595021 gaacttctgg tcgcgatgaa agacccgggc gatgttgatc gggatattga acttggtgaa
595081 gatctccagc tgcacgcgcc ggccggcgat cgccaggaag gtcagcgggg ctaccagcgc
595141 ggggtaaccg gccgctgcgg catccggctc gctgtagtgg gtcgggtggt cgtctttgac
595201 cgcgaccgcg aactcgcgga tcttctcgcg ccccaccaga aagtggtccg gcgcccgata
595261 atgcttgccg atcagtgtct gggcttcttc gggaactgtc atgccgctgc cgccctccgc
595321 tcgaatagtt gctaagccct attgcccggc tcctcctcgc cccgctgcgc gggtcgcatc
595381 gtcgccaggc tgggccctat tgcccggctc ctcctcgccc cgctgcgcgg gccgcatcgt
595441 cgccaggcta acggcgcagc ttatcagcgt gattggcgtc tagaggctag agccgccaac
595501 gcgccgccgg ccgcacccag cgccagggcc gacggaaccc cgatccgagc ggccttgcgg
595561 gcgattcgga aatcacggat ctcccacccc cgttcccggg ccaggctgcg caggcgggcg
595621 tcggggttga tggcgaccgc ggtgcccacc agcgacagca tcgggacgtc gttgtagctg
595681 tcggagtagg cggtgcagcg tttgagattg agtccctccc ggatggccag cgaccgcacc
595741 gcgtgtgcct tgccggtgcc gtgcaggatc tcgccgacca gtctgccggt gaatatcccg
595801 tcgaccgact cggcgacggt gcccagggcg ccggttaggc cgagccggcg ggcgatggtg
595861 gccgcgagtt cgtatggggt agcggtgatc agccatacct gctggccggc gtccaggtgc
595921 atctgggtga gttcgcgggt gccgtcccag atcttgtcgg cgatgatctc gtcgtaaatc
595981 tcctctccca aggccaccaa ctccgcgacg gatcggccct cgatgaacgc gagcgccttg
596041 cgccggccag cggcgacgtc gttgctgttc tccttgccaa gtagctggaa cttggcctga
596101 gcgtaaagaa atccgaggac gtcgcggtag gtgaagtagt ggcgagcggc tagcccgcgg
596161 ccgaagtgca ccgccgacga gccctgaacc aaggtgttgt ccacgtcgaa gaaggcggct
596221 gcggtcaggt cgatcggcgg ctgccgatcg ctgccggcgg cggcgacggg ggccggcatg
596281 tccaccggcg agtggctggc gctggcatcg ggtggcggcg ggtcggccgg cgaagccagg
596341 tcgacgtgac cggcctggtc tgggctaccc aggtgggagg aaaccatcat tactcctaat
596401 cgcggtgcct gcccggtggc cgatgctgcg gccgttatca accctatccg gcaaatgcgc
596461 ggcggagctc ttggctggcg cggattgatc tgcaagccca gcgcggtatc gaaattcgcg
596521 aggccgcagc gactttcgtc gtgaacacga cccgcagcgg ttcggggcca acatgtcagc
596581 cccataccgg tacgcgcaaa gctgggtacg tgaaatcctg aattcttcag cctgtcaacg
596641 gtagcgtcta cgctagctaa cgcaacgaga catccgatta ctacgcacgt taggacattt
596701 caggaggtat cgggaggcct aagggtcact aggtccgcgc gatgggcgga acacgagggt
596761 gaggatgatt tcggttagcg gcgccgtgaa acgcatgtgg ttgctgctgg ccatcgtcgt
596821 ggtggccgtt gtcggggggc ttggtatcta tcggctgcac agcatcttcg gtgttcacga
596881 gcaacccact gtcatggtca agcctgattt cgacgtcccg ctgttcaacc ccaagcgggt
596941 gacctacgaa gtctttggcc ccgccaagac cgcaaagatc gcctacctgg accctgatgc
597001 ccgggtgcat cgactcgata gcgtgtccct gccgtggtcc gtcacggtcg agacgacgct
597061 gcccgcggtc agcgtcaacc tcatggcgca gagtaacgcc gacgtgatca gctgccggat
597121 catcgtcaac ggcgccgtta aggacgaaag gtctgagacc tcgccgcgag cgctaacctc
597181 ctgccaggtg tcatccggat gagcgaaaga cacgccgcac tgacgtcact gccgcccatt
597241 ctgccgcggc tgatccgccg gtttgcggtg gtgatcgtcc tgctctggct gggcttcacc
597301 gcctttgtca atctcgccgt accgcaactg gaagtggtcg gaaaagcaca ctcggtatcg
597361 atgagcccca gcgacgccgc atcgattcag gcgatcaagc gcgttggtca ggtgttcggt
597421 gagtttgatt ccgataacgc ggtaacgatc gtgctggaag gcgaccagcc actcggtggg
597481 gacgcgcacc ggttctatag cgatctgatg cggaagcttt ccgccgatac ccgccatgtc
597541 gcgcacatcc aggacttctg gggggatccg ctgacagcgg cgggatccca aagtgcggat
597601 gatcgggccg cctacgtcgt ggtgtacctc gtcggtaaca acgaaaccga agcgtatgac
597661 tcggtccacg cggtgcggca catggtggac accacaccgc caccgcacgg ggtgaaggcc
597721 tatgtcaccg gtccggcagc actcaatgcc gaccaggccg aggccggaga caaaagtatc
597781 gctaaggtca ccgcgatcac gagcatggtg atcgcagcaa tgttgctagt gatctatcgc
597841 tccgtaatta ccgcggttct cgtcttgatc atggtcggca tcgacctcgg cgcaatccgc
597901 ggattcatcg ccttgctcgc cgaccacaac attttcagcc tttcaacatt tgcgaccaac
597961 ctgctcgttc tcatggcgat tgcggcgagc acggactacg cgatattcat gctcggccgt
598021 taccacgaat cgcgctacgc cggcgaggat cgggaaacgg ccttctacac gatgtttcac
598081 gggaccgccc acgtgatctt gggttcgggt ttgaccattg ccggcgccat gtattgcctc
598141 agctttgccc ggcttccgta ttttgaaacg ctcggcgcgc ccattgctat cggcatgctg
598201 gtcgcggtct tggcggcgct cacgctcggc ccggccgtac tgaccgtggg cagcttcttc
598261 aagctgttcg atcccaagcg gcggatgaac actcggcggt ggcgccgggt gggaacggca
598321 attgtgcgtt ggccggggcc ggtgctcgcg gcgacatgct tggtcgcctc cattggcttg
598381 ctggccttgc ccagttaccg gacaacgtat gatctgcgca agttcatgcc cgccagcatg
598441 ccgtccaatg tgggggatgc ggcggctggt cgacgctttt cacgggctcg gctgaaccct
598501 gaggtgctgt tgatcgagac tgaccacgat atgcgtaatc cggtggacat gctggtgttg
598561 gacaaggtag ccaaaaatat ctaccacagt cccggtattg aacaagtgaa agcgataacc
598621 cggcccttgg gaacaaccat caagcacact tcgataccgt tcatcatcag catgcagggc
598681 gtgaatagta gcgagcaaat ggaattcatg aaggaccgaa ttgatgacat actggtgcag
598741 gtggccgcga tgaatacctc catcgagacg atgcatcgca tgtatgcact catgggcgag
598801 gtcattgaca acaccgtcga catggatcat ctcacgcatg atatgtcgga cataacggct
598861 acgctaagag atcatctcgc ggatttcgag gatttcttcc ggcctattcg cagctacttc
598921 tactgggaaa aacattgttt cgacgttccg ctctgctggt cgataagatc gatattcgat
598981 atgtttgaca gtgtggacca gctgagcgaa aagctcgagt acctggtcaa ggatatggat
599041 attctgatta cactgttgcc gcagatgcgc gcgcagatgc cgccgatgat atctgcgatg
599101 acgacgatgc gggacatgat gcttatctgg catggcacgc ttggcgcgtt ctataagcaa
599161 caggagagga ataacaagga ccccggcgcg atgggccggg tttttgacgc cgcccagatc
599221 gatgattcgt tctatctgcc gcagtcggct tttgagaatc cggatttcaa gcgggggctg
599281 aagatgtttt tgtctccgga cggcaaggca gcccgctttg tcattgctct ggagggagat
599341 cccgcaacgc ccgagggcat ctctcgggtc gagccgatca agcgggaggc tagagaggcc
599401 ataaagggaa ctccattgca gggcgctgcg atctatctgg gtggcaccgc ggcgacgttc
599461 aaggatattc gagagggcgc cagatacgat ctgctgatcg ccggagtggc ggcgataagc
599521 ttgattttga tcatcatgat gatcatcacc cgaagtgtgg tagccgcagt ggttatcgtg
599581 ggtaccgtcg tgctttccat gggcgcctct ttcgggcttt ccgtattggt ctggcaggac
599641 attctgggta tcgagttgta ctggatggtg ttggcgatgt cggtgatcct gctcctggcg
599701 gtgggatccg actacaatct gctgctgatt tcccggttga aagaggaaat tggggccgga
599761 ttgaacaccg gaattatccg tgccatggct ggtaccgggg gagtggtgac ggctgccggc
599821 atggtgttcg ccgttaccat gtcgttgttt gtgttcagcg atttgcgaat tattggtcag
599881 atcggtacca ccatcggcct gggcttgctg ttcgacaccc tcgtcgtgcg ctcgttcatg
599941 acaccgtcca ttgctgcgct gctgggacgc tggttctggt ggccgctacg ggtgcgcccg
600001 cgcccggcca gtcagatgct tcggccgttc gcgccgcgcc gattggttcg cgccttgttg
600061 ctgccgtccg gccagcaccc gtcagcgact ggcgcccatg agtaggcccc aggtggagct
600121 tttgactcgc gccgggtgcg cgatctgcgt gcgggtagcg gagcagctgg ccgaactgtc
600181 cagcgaactg ggcttcgaca tgatgacgat cgacgtcgat gtcgcggcgt cgacgggcaa
600241 tccagggctg cgagctgagt ttggcgatcg gttgccggtg gtcctgctgg acggccgcga
600301 gcacagctac tgggaggtcg acgagcaccg gctgcgtgcg gatatagccc gcagcacatt
600361 tggtagccca cctgataaac gtctaccgta gacaccagtt ttactggggt agtcgaggga
600421 gctggccagg tggtgctgcc gtgagcgtgc tgctcttcgg ggtgtcgcat cgtagcgcgc
600481 cggtcgtcgt ccttgaacaa ctcagtatcg acgaatccga tcaagtcaag atcatcgacc
600541 gagtgctggc ttcgccgctg gtgaccgagg cgatggtgct gtcgacttgc aaccgcgtcg
600601 aggtctacgc cgtagtggac gcgttccatg gcggcctgtc ggtgatcggg caggtgcttg
600661 ccgaacactc cggtatgtcg atgggggagc tgaccaagta cgcatatgtc cgctacagcg
600721 aggcagcagt tgagcacctg ttcgcggttg ccagcggcct ggactcggcg gtgatcggcg
600781 agcagcaggt gcttggtcag gtgcgccgcg cctatgccgt cgccgaatcc aaccgcacgg
600841 tcggccgcgt gctgcacgaa ttggcccagc gggcgctgtc ggtgggcaag cgagtgcact
600901 ccgaaaccgc cattgacgct gccggtgcct ccgtggtgtc ggtcgccctg ggaatggccg
600961 agcgcaaatt gggctcgttg gcgggcacga ccgcggtggt gatcggcgcc ggggcgatgg
601021 gcgcgctgtc ggcggtacat ctgacccgtg ccggcgtcgg gcacattcag gtgctcaacc
601081 ggtcgttgtc ccgggcgcag cggttggccc gaaggatccg cgaatctggc gtgccggccg
601141 aggcgctagc gctcgaccgc ctggctaatg tcctggccga tgccgacgtg gtggtcagct
601201 gtactggggc ggtgcgtccg gtggtgtcgc tggccgatgt gcatcatgcg ctggccgccg
601261 cccgccgtga cgaggccacc cgtccgttgg tgatatgcga cttgggcatg ccgcgtgacg
601321 tcgatcctgc ggtggccaga ttaccgtgtg tgtgggtcgt ggacgtggat agcgtgcaac
601381 atgaaccctc ggcacatgcc gcggctgccg acgttgaggc cgcccgccac atcgtcgccg
601441 ccgaagttgc cagctatctg gtggggcagc ggatggccga ggtcacccca accgtgacgg
601501 cgttgcgcca gcgagccgcc gaagtggtcg aagcggaatt gctgcgcctg gacaaccggc
601561 tgcccggcct gcagagtgtc cagcgcgagg aggtggcccg caccgtacgg cgagtcgtgg
601621 acaagctgtt gcacgcgcct accgtgcgga tcaagcagct cgccagtgcg cccggcggtg
601681 acagctacgc cgaggcgctg cgcgaactct tcgagcttga ccagaccgcc gtcgatgccg
601741 tcgccactgc aggtgaatta ccggtggtgc caagcggatt cgacgctgaa agtcgccgcg
601801 gtggaggcga catgcaaagc agcccgaagc gatcgccgag taactgattg gcgcacgtga
601861 tccggatagg tacccggggc agcttgctgg ccaccactca ggccgccact gtcagagacg
601921 ccctcatcgc tggtggccac tccgcggagt tggtgaccat cagcaccgag ggtgaccgat
601981 ccatggcgcc gatcgccagt ctcggggttg gcgtcttcac cacggcgttg cgcgaggcga
602041 tggaggcagg cctcgtcgat gcggcggtgc attcgtacaa ggatttgccg actgccgccg
602101 atccaaggtt cacggttgcg gcgataccgc cgcgcaatga cccccgcgac gcggtggtag
602161 cccgtgacgg gctgacgctg ggggaattgc cggtcggatc gttggtgggc acatcctcgc
602221 cgcggcgggc cgcacagctt agagcattgg gtctcggttt ggaaatccgc cccctacgag
602281 gcaacctaga taccaggttg aacaaggtaa gtagcggcga tcttgacgcc atcgtggtgg
602341 cccgggctgg tctggcgcgg ctgggccgcc tcgatgacgt gaccgagacg ttagagccgg
602401 tgcagatgtt gcccgcgccg gctcagggcg cgctcgcggt cgaatgccgc gccggcgaca
602461 gccggttggt ggcagtgctg gcggagttgg atgacgccga cacgcgtgcg gcggtcaccg
602521 ccgagcgagc cctgcttgcc gacctggagg caggttgctc cgcaccggtg ggagcgatcg
602581 cagaagtggt cgagtccatc gatgaggacg gccgtgtctt cgaggagctg tcgctgcgcg
602641 ggtgcgtggc ggcgctggac ggatccgacg tgatccgcgc gtccggcatc ggcagttgcg
602701 gtcgggcacg ggagctgggg ctctcggtcg ccgcggagct gttcgagctg ggcgcccggg
602761 agctgatgtg gggagtgcgg cattagcccg catgaagaag tgactgggag tgacaatcat
602821 gacgcgaggg cgtaagccga gaccgggccg catcgttttc gtgggctccg gtccgggcga
602881 ccccggcttg cttacgacac gggctgccgc ggtgctggcc aacgccgcgc tggtgttcac
602941 cgatcccgac gtaccggagc cggtggtggc gctgatcggc acggatctgc cccccgtgtc
603001 cggcccggcg cccgccgagc cggttgccgg gaacggcgat gcggccggcg gaggaagtgc
603061 gcaggaacac ggccgggccg cgtccgcggt agtctccggt ggtcctgaca tccgcccggc
603121 gctgggcgat cccgccgatg tggccaagac gctgaccgcc gaggcccgtt cgggtgtcga
603181 cgtggtgcgg ctggtggcgg gcgatccgct cacggtggat gcggtaatca gcgaggtgaa
603241 cgccgtcgca cgcacccacc tgcacatcga aatcgtgccc ggcctggccg ccagcagcgc
603301 ggtcccgacc tatgccgggt tgccgctggg ttcgtcgcac accgtcgccg acgtgcgtat
603361 cgaccccgaa aacaccgact gggacgcgct ggctgccgca cccgggccgc tgatcctgca
603421 ggccaccgca tcgcatctag ccgaatcggc ccgcagcctg atcgatcacc agctggccga
603481 gtccactccg tgcgtggtga ccgcacacgg caccacctgt cagcagcgtt cggtcgagac
603541 cacacttcag ggattgaccg acccggccgt cctgggcgct accgaccccg cgtgctccgc
603601 aaacgggagg gactcccagg ccggaccgct gatagtgacc atcggcaaga cggtgaccag
603661 tcgggcaaag ctgaactggt gggagagccg cgccctctac ggctggacgg tgttggtgcc
603721 gcgcaccaag gaccaggccg gcgagatgag cgagcggctc acgtcgtacg gcgcgctgcc
603781 ggtggaggtg ccgaccatcg ccgtcgagcc gccgcgcagc cccgcgcaga tggagcgcgc
603841 cgtcaagggc ctggtcgatg gccgattcca gtggatcgtg ttcacctcca ccaacgcggt
603901 gcgtgcggtg tgggagaagt tcggcgagtt cggtctggat gcccgcgcgt tctccggggt
603961 gaagatcgcc tgtgtcggcg agtcgacggc cgaccgggtg cgcgccttcg gaatcagtcc
604021 cgagctggtg ccctccgggg agcagtcctc gcttggcttg ctagacgact tcccgcccta
604081 cgacagcgtt ttcgacccgg tgaaccgggt tttgctgccg cgcgccgaca tcgccaccga
604141 aacgctggcc gagggactgc gagagcgtgg ctgggagatc gaggacgtca ccgcctaccg
604201 gaccgtgcgg gccgcgccgc cgccggccac tacccgggaa atgatcaaga cgggcgggtt
604261 tgacgcggta tgtttcacct ccagctcgac ggtgcgaaac ctggtcggca tcgccggcaa
604321 gccgcacgcg cggacgatca tcgcctgcat agggccaaag accgccgaga ccgcagccga
604381 gttcggcttg cgggtcgatg tccagccgga caccgccgcc atcggcccgc tggtcgatgc
604441 gctggccgag catgccgccc ggttgcgcgc tgagggtgcg ctgcccccgc cgcgcaagaa
604501 gagccgcagg cgctagtggc ccaccctcgt caggtgagcg tgcgtgtctg tacaccgaca
604561 cgccgaccga gctggcattt tgcgtacgct cgcggctacg aatgagcatg agttcctatc
604621 cgcggcagcg accgcgccgg ctccgctcca ccgtcgcgat gcgccgtctg gttgcgcaaa
604681 cctcgttgga gccaaggcat ttggtgctgc cgatgttcgt tgccgacggc attgacgagc
604741 cgcggccgat tacctccatg ccgggcgtgg tacagcacac ccgggattcg ctacgtaggg
604801 ccgcggcagc cgcggtggcc gccggcgtgg gtgggctgat gcttttcggc gtgccgcgcg
604861 accaggacaa ggacggtgtc ggttcggcgg gcatcgaccc cgacgggatc ctcaacgtcg
604921 cccttcgcga tctggccaag gacctgggtg aggccacggt gttgatggcc gacacctgtc
604981 tggacgagtt caccgaccac gggcactgcg gtgtgctcga tgaccggggc cgggtcgata
605041 acgacgccac cgtggcccgc tatgtggaac tggctgtggc gcaagcggaa tcgggcgccc
605101 acgtggtcgg acccagtggg atgatggatg gccaggtagc cgcgatccgg gacggtttgg
605161 acgccgccgg ctacatcgat gtggtgatct tggcctacgc cgcgaagttt gcttcggcgt
605221 tctacggccc gttccgcgag gcggtgagct ctagcctgtc cggggatcgg cgcacctacc
605281 agcaggagcc gggcaacgcc gccgaggcgc tgcgtgagat cgagctcgat ctcgacgaag
605341 gcgccgacat tgtgatggtc aaacccgcga tgggctacct cgatgtggtg gcggccgcgg
605401 cggacgtctc gccggtcccg gtggccgcct atcaggtctc gggagagtac gcgatgattc
605461 gtgcggcggc ggccaataat tggatcgatg agcgtgccgc ggtgctagag tcgctgaccg
605521 gtatccggcg tgccggcgcc gacatcgtgc tcacctactg ggcggtagac gcggcgggct
605581 ggcttacgtg acggaggcct gacatgacac caaccgggga taccaagccc aagttgttgt
605641 tctacgaacc cggcgcgagc tggtactggg tgctgactgg tccgcttgcg gcggtgtcgg
605701 tgctcctcct cgagatatcc agcggcgccg gggttgggtt gataacgccg gcgatctttc
605761 tggtgatggt gtcggcgttc gtggcattgc aggtgaaggc ggcgcggatt cacacgtcgg
605821 tcgagctgac gcatgatgcc ttgcgccaag gcaccgagac catcaggctg gccgaaatcg
605881 tcaaaatcta tccggaggca gacggccgcg agacgtccgg ggaagagccg gcaaagtggc
605941 agtcggcgcg gaccctgggc gagctcgtcg gcgtaccgcg cggccgggtg ggaatcgggc
606001 tgaagctgac cggaggccgc accgcccagg cctgggcgcg tcgtcatcaa cagctgcggg
606061 cggcgctgac tccgctggtt caggagcggc tcgggcccgt ggattctgat gtcgccgacg
606121 tcaacggtga cgacgccggg ccagcgcggt gatcgcccgc taccgggccg gggccgaact
606181 gttcctggct tgtgccgcgc ttgccggatc tgcggcgagc tggtcgcgga cccgctccac
606241 cgtggccgtc gcgcccgtca tcgacggcca gccggtcacc ctgtcggtgg tctatcaccc
606301 gcaaccgttg gtgctgaccc tgctgctggc gacgatcgcc ggcgtgttgt cggtggtggg
606361 gacggccagg ttgcggcgcg cgcgagctgg cttgaacgca catccggacg gcttgaacca
606421 gcgtccgccc ggcggttggt gtcattgagc cgtttgcgtg gatcacttcc gctgctgctt
606481 gatcgggccc tggtctgtgt cggcagcggc tggtagtatc gaaagtatgt tcgatcaggt
606541 gcgggggcgc atgccttcac cggaggcgat cgctcatttt gatgagcggt ttgaatgcca
606601 tgctccgcgg accacgaggg tgtcggcggc gttcatcgat cggatctgct cggcgactcg
606661 ggccgaaaac cgggccgctg cggcgcagtt ggtggcgttg ggggagttgt tcgcctatcg
606721 gtggtcgcgt tgcgggggcc gcgaggagtg ggtgatggac accatggcgg cggtggccgc
606781 cgaggtggcg gcggcgttgc ggatcagtca gggtctggcg gccagccggt tgcggtatgc
606841 gcgggcgatg cgtgagcggc tgcctaagac ggctgaggtg tttagcgccg gcgacatcgg
606901 ctatctgatg tttgccacga ttgtgtatcg caccgacttg atcgttgacc ctgatgtttt
606961 ggcggcggtg gatgcgcagt tggccgccaa tgtggcgcgt tggccctcga tgaccaaggc
607021 ccgcctggct gggcaggtcg ataagatcgt ggcgcgtgcc gatgccgatg cggtgcggcg
607081 gcgcaaggag tatcaggccc agcgccagtt ctgggtcggg gaaagccaag acggtgtgtg
607141 ccagatcggt ggcagcctgt tggccgtcga cgcacacgcc ctcgatgcgc ggttgagcgc
607201 gttggcgggc accgtgtgtg agcacgatcc gcgcagccgt gagcagcgcc gcgcggacgc
607261 gttgggggcg ttggcgggcg gggccgatcg gctgggctgt ggctgtgggc gcgctgattg
607321 tgcggccggg aagcggcctg cggccccgcc ggtggtgatt cacctgatcg ccgaggcggc
607381 cacgatcaat ggcacgggct cggcgccggc atcgcagatg aacgccgacg ggctgatcac
607441 cgccgaactg gtggccgagc tggccaagac ggccacgctg gtgccgctgg ttcatcccgg
607501 cgatgcgccg cccgagccgg ggtatgcgcc gtcgaaagcg ctcgccgatt tcgttcgctg
607561 ccgggatctg acgtgtcgct ggcccggctg tgatgagccc gccaccaatt gcgacctgga
607621 tcatacgatc ccgtatgccg ctggtgggcc cacccatgcg tcgaacctga aatgttactg
607681 ccgtacccat cacctggtga aaacgttttg gggatggcgt gatcaacagc tacccgacgg
607741 caccctgatt ttgacctccc cgtccgggca tacctatgtc agcaccccgg gcagtgcgct
607801 gctgttcccc agcttgtgcc acttcagcgg cggcatcccg gcaccggaag ccgacccacc
607861 ctacgaccat tgcgaccagc gcacagcgat gatgcccaaa cgccggcgca cccgcgccca
607921 agaccgggcc tatcgcatcg ccaccgaacg tcgacaaaac cacgccgccc gccagcgcgc
607981 ccaggtgctc acccagaccg ccgcggccac cgacacccac ggcccaccac cggatcacaa
608041 cgacgaccca ccgccgtttt aggctgacct gctgattagc ggtagcacca gctgacggcg
608101 gcggtcgatg gcgtcagcca ggtcgtggag cgctttatgc accgagcgcg ccatcgggaa
608161 catggattca tgctcgccct ggtcacagcg gccacctagc tgttcgacta ctgcggggct
608221 cgcgactaat gcccactgga cgccggcggc tcggcagtcc tcatcgagga tgcacaagag
608281 cgagatgccg gccccactga agtgactcaa ctcgctcagg tcgagcacca tcggatttgt
608341 tccgaggctg aaacgccgga cgtgctcgct gatctgctcg acattggcgg cgtcgatctc
608401 gcctcggatg gtcaccactg tcgccaggtg atgcaggtag gcccgaatct gagcgccacc
608461 gtagtcaacg gcggcatttc cgggccgcgt cgtgacgctg caagccgatt ttgacgtcgg
608521 gatcgtggta gtcatcaata gcctcgttct ccgtcgcgtt gcgggccgac cgatcgccgg
608581 ctaaagctgc ctttaaccaa acccgcaaaa tctaagggga gcgaaagccg cctctaactc
608641 tttgctaaga agcgattttc ggggtgctcc cggcgaccca cgccgtcgcg gccatggcgc
608701 tgttaggctg cgatggctgc cggttgctag tcgggggctg atgatatggc cggtggtatg
608761 gatcagccgc ccggtcagcc tagaaggcgg accagacagc agagttcaga cggaaagaac
608821 ggcgtgcgcg ctgcagagat caccggagaa attagggccc tgacaggatt gcgcatcgtc
608881 gcggcggtgt gggtagtgct gtttcacttc cgaccgatgt tgggtgatgc gtcaccgggc
608941 ttccgcgacg ccctcgcgcc ggtgctcgac tgcggcgcgc agggtgtaga cctcttcttc
609001 atcctcagtg ggttcgtgct gacctggaac tacctcgacc gcatgggccg gtcgtggtcg
609061 gtccgtgcca acctgcactt cttgtggctg cggctggcca gggtgtggcc ggtgtacctg
609121 gtcaccttgc acctggccgc cgtgtgggtc atctttacgc tgcacgtcgg tcacgtgccg
609181 tctccggagg caggccagct gaccgcgatc agctatgtgc gccagatcct gctggtgcag
609241 ctgtggtttc agccgtattt cgatggatcc agttgggatg gaccggcctg gtcgatcagt
609301 gcggaatggt tggcctactt gctgttcggt ctgctcattc tggtcatctt ccggatgaag
609361 cacgccacca gggcgcgggg cctgatgtgg ctggccttcg cggcgtcgtt gccgcccgtg
609421 gtgctgctgt tggccagcgg ccagttctat acgccatgga gctggctgcc ccgaatcgtg
609481 acgcaattcg ccgcgggagc gctggcgtgt gccgccgtcc gcaggttgcg gccgaccgat
609541 cgcgctcgcc gcatcgccgg gtacctttcc gtgctggtcg gcgtcgcgat tgtcggcatc
609601 ctctacctgt tgcacgcgca tccgctcgcc ggggtcgagg acagcggcgg ggtggtcgac
609661 gtgctgttcg ttccgctggt gatcagcctg gcgattggcg tcggcagcct gccggcgttg
609721 ctgtcgacgc ggttgatggt ttttggcggg cagatctcgt tttgcctcta catggtgcac
609781 gagctggtgc ataccgcctg gggatgggcc gtgcaacaat acgagcttgc gctgcaggat
609841 cagccgtgga aatggaacgt cgtcggtctg ctcgcgatcg ccctgggggc tgcgatcttg
609901 ctgtatcact tcgtcgaaga accgggccgc cgatggatgc gccggatggt cgacgtcaaa
609961 gccgcgagtg cgagaagcga gcccggggag ccggtaggca gcacgcgtta tcaaatcgac
610021 gatgcgctgg aaggggtttc ggcccgcgcg gtgtgacggt tgagtggggc tgcagcgggt
610081 cgacgcgagt tcacatcggt ttcctcgtac gattcccttt atttggacgc ggcgcacgac
610141 ccgttcaact ttgagccgag tccagtggag ccatcagtgg agtcagtgtg agtcgcccgg
610201 gtacatacgt cattggtctc actctcctgg tcggcctggt cgtcggcaat ccagggtgcc
610261 cgcggtccta ccgcccactg accctggatt accggcttaa cccggtcgcg gtgattggcg
610321 actcctatac caccggcacc gatgagggcg gtctgggctc gaaatcatgg accgctcgca
610381 cctggcagat gctcgctgca cgtggcgtgc ggatcgcagc cgacgtggcc gccgagggcc
610441 gggccggcta cggggtgccc ggcgaccacg gcaacgtgtt tgaggatctg accgccaggg
610501 ccgtccagcc cgacgatgca ctggtggtgt tctttggctc ccgcaacgac caaggcatgg
610561 atcctgagga tcccgagatg ctggccgaaa aggtccgcga cactttcgat ctagcgcgcc
610621 accgcgcacc atccgcgagc ttgctggtga tcgcaccgcc gtggcctacc gccgacgtac
610681 ctggcccaat gctgcggatt cgcgacgtgc tgggcgctca ggcgcgggcc gcaggagcag
610741 tgtttgtcga cccgatcgcc gaccactggt ttgtcgacag gcccgagctg atcggcgcgg
610801 atggcgtgca tcccaacgat gcgggacatg agtatctggc ggacaagatc gcgccgctga
610861 tcagcatgga gttggttgga tgagttggga gtcacgagcc acgcaaaggg tttagcgtga
610921 cgacggtcga cgtgctagtc ctctgcgtgc cgttcgtaat cccaacgctc aaggcgcgcc
610981 tgcaactgca ggagaccaag tccggcgagt ggcgccgcgg cggtgaggaa ggccagcagc
611041 atcggactca tctcagaacc tccaaaacca tttcattcgt accacgttcg tcgtcgaggg
611101 gtggttcttt cgcgaaacat gtccgtccga attcagctgt cctcagccac cgccacgctg
611161 cgccacgtca gctaggacgc catccaagcc agttcgccgg gcaactgttc gcgccagtac
611221 gacgcgtcgt gtcctccggg cgagaagctg ccggcaggcg gttggtgcag ttggttgacg
611281 aattggcgag tggcgaagta gaagcggtcg ctggtgccgc aatccacccg tagcgggatt
611341 gagttcagcg cgggcaggcc caacacgctg tgttgcacat agtcgtcgta gctgtcgaac
611401 gccccgggtg tgctgccggt gaacgacgtg aacaatgccg ggctgatggc acagatcccc
611461 gcggttctgg ccggacccaa ccgggcaccc aggagcagcg cgccgtatcc ccccatcgac
611521 caccccagga atcccacccg ggaggtgtcc atacccatcg aggtcagcat cggcagcagc
611581 tcgtcgagca ccatcgcacc cgagtccccg ccggaagagc gacggtgcca gtaggtgttg
611641 ccgccgtcga cgccgaccac cgcgaacgct ggcttgccct ccttgaccag gcgggccaac
611701 ccctgctcga cgccgagatc cagcatcatg ccggcgttgc cgtccttgcc atgcagtgcg
611761 atcactggcc gcagctgccc gctctggccg ggcggcatgg agatcaccca gttggtcttg
611821 atgcctccgc gagccgccga gatgaacgag ccggagatcc tggtcggcaa gctgctgccc
611881 gccgtcgggg gctcgaacgg cgccggggcc gcctgcggct caagtgggtc caccagggcg
611941 ccgaaggccc acacgccggc ggctcccgcg ccggcgccgg caccccaacg gagcagggca
612001 cggcgggtca ggtctgccat gggcgtcatg atgccgcgcc gatcggtgtt gcccgcacag
612061 ccacgccgta gcaccggcca atcgtgacac cggtaacggc tggcgagtcg ccgtagtggg
612121 ggcccggctg cgcagcagtg acggcatgaa gaactttcgc aaaactggaa acggctggta
612181 ccggaagtcg gtattctttg cgcggcagct gcgtgtcaat gatgaccgag cggtagcccg
612241 gtcgtccctg gtgtatggga gggtgttcga tcacctgcct caacatctcc gaagtgccga
612301 acgagaccaa ccgtaagaag aaccgtcagg ccggactcga ccgcagtatc cgggtgattc
612361 atggcagctt cgacgacatt cccgagccgg acagcggcta tgacgtcgtc tggtcacaag
612421 atgcgatcct gcacgcgccc gaccgccgaa aggtgctcga ggaggcattc cgggtgttgc
612481 ggcccggcgg cgaactgatc ttcaccgatc cgatgcaggc cgacgatgtt cccgacggtg
612541 tgctgcagcc ggtctacgac cggctcaacc tgcgtgacct tggctcgatg cgcttctatg
612601 cgtgaagccg cacaggcact cggtttcgag gtgctcgacc aaagagacct ggttcgcaat
612661 ctgcggacgc actacagccg agtgttcgag gaactcgaag cccggcgtct cgaactcgag
612721 gggaagtcct cccaggagta cctcgacaag atgcgggtag gcctgaagaa ctgggtcgag
612781 gccgccgaca acggtcactc tcgcgtgggg catccaacat ttccgagaac ccgcctgact
612841 ccgatatgcc agctgcccac ggccgcgatc gactcgacgg ctggtcgtcg ccggtatcgt
612901 tgaccccacg gactgcgtga cagccggggg cacggagttg cccggcggcg ccagtactgc
612961 ccccgacgga ccggaaggca ggtgccatag ctaccacttc aggactgcgc ccaggactgt
613021 cgcagcgtca gctcaacatg atcgctatcg gcggcgtcat cggtgctggc ttgttcgtcg
613081 ggtctggtgt ggttatccgt gcgaccggtc cggcggcatt cctgacctat gcgctgtgcg
613141 gcgcactgat cgttctggtg atgcgcatgc tgggcgagat ggccgccgcc aatccgtcga
613201 ctggagcgtt cgccgactac gcggcaaaag ccctgggcgg ctgggcggga ttctcggttg
613261 gctggctgta ctggtacttc tgggtaatcg tcgtggggtt cgaggcggtt gccggcggga
613321 aggttctaac ctactggatc gatgcgccgc tgtggttggc gtcgctgtgt ctgatgatga
613381 tgatgaccgc gacgaacttg gtctcggtgt catccttcgg tgagttcgag ttctggttcg
613441 ccggagtcaa ggttgccacc atcgtcggct tcctggtcct tggcaccgct ttcgccttcg
613501 ggctgctgcc gggccatggc atggatttca gcaacctcag cgcgcacggt ggcttctttc
613561 ccgacggggt aggtgccgtc ttcgctgcca tcgtggtcgc gatcttctcc atgactggca
613621 cggaagtagt caccatcgcc gcggctgaag cgccggaccc tcaacgagcg gtccaacgcg
613681 cgatgagcac ggtggtggca cgcatcgtga tcttcttcgt cggctcggtc ttcctgctca
613741 cggtgatcct gccgtggaac tcgttggagc ttggcgcctc cccgtacgtt gccgcgctgc
613801 ggcacatggg tattgggggt gctgatcaga tcatgaatgc cgtcgtgctt accgcggtgc
613861 tgtcctgctt gaactcgggc ctgtataccg cgtcgcggat gctgttcgtg ctcgccgccc
613921 ggcaggaggc gccggcccag ctggtcaaag tcaaccggcg tggagtcccc accttcgcga
613981 tcatgggatc gtccgtggtg ggattcctgt gcgtgatcat ggcatgggtc tcacccgcaa
614041 cggtattcgt tttcctgctc aactcgtcgg gcgctgtgat tttgttcgtc tacctgctta
614101 tcgcgctgtc gcagatcgtg ttgcgtcgcc agacatctgg ccaaaatctg ggggtacgga
614161 tgtggctttt cccggggctg tcgatcgtca cggtgaccgg aattgtcgcc gtgctggcgc
614221 ggatggcgtt cgactacgcc gcgcgcagcc agctctggct cagcctgctg tcctgggcag
614281 tggtcgttgg gtgttatttg gtcaccacat tggtgcgacg tccccttaat cggccttggt
614341 gagcagtacg gcctcgtcga acggcagtct ggcaaagacc ggccgccatc ggctgctgac
614401 atacggcgcc gcctcggcct tggtgagccg ccgcgggttg gcgacaccaa aggttttgcc
614461 gtagcggcgc atccggccac cgccggccgc ggtgatgttc ttcagccagt cgcggttcgg
614521 accgtaggtg agcaaaatcg ccacgcccgc ccggccgtcg acgtccgcgc tgaacacgtt
614581 caacggggta cggtacggct tgcccgagcg gcggcccacg tgctcaagaa tcgcgaacgc
614641 cgggagccag ccggcccata gccgctgaat ggggttggtg acatatcgat tgaaccgagc
614701 cagccactgc ggtagttgca tgcccaccat ccaactcgtg gaccggccgc ggcatcaagc
614761 aaacctctgg tggctgcggc aaactcttac accctgtagt tgagcgacct gggcaggctg
614821 gaacactagt cgtcatgggc agcacggaac aggccacctc gcgggtaagg ggagccgcgc
614881 gcacatcggc gcagctgttc gaggccgcat gcagcgtcat acccggcgga gtgaactccc
614941 cggtgcgggc gttcacggcg gtgggcggca ccccgcgctt cattaccgaa gcccacggct
615001 gctggttgat tgacgccgac ggcaaccgct acgtagacct ggtctgctca tggggcccga
615061 tgatcctcgg tcacgcgcat ccggccgtcg tcgaggcagt ggccaaggcc gcagcccgcg
615121 gcctgtcctt cggggccccg actcccgccg aaacccaact agccggcgag atcatcggcc
615181 gggtagctcc cgtcgagcgg atacggctgg tgaactccgg caccgaggcc actatgagcg
615241 ccgtgcggct ggcccgcgga ttcaccggcc gggccaagat cgtcaagttc tccggctgct
615301 accacggaca cgtcgacgca ttgctcgccg acgcgggttc gggagtggcc accctgggct
615361 tatgtgacga cccccagcgc ccggcttcgc cgcgctcgca atcgtcacgg ggcctgccgt
615421 cctcccccgg ggtcactggc gccgcggcag ccgacacgat cgtgttgccc tacaacgaca
615481 tcgatgccgt acagcagacc ttcgcccggt tcggcgagca gatcgccgcc gtaatcaccg
615541 aggccagccc cggcaacatg ggagtcgtcc cgcccgggcc cggcttcaac gcggcgctgc
615601 gcgcgatcac cgccgagcac ggcgccctgc tcatcctcga cgaggtgatg accgggttcc
615661 gggtcagccg aagtggttgg tacggaatcg atccggtgcc cgctgacctg ttcgccttcg
615721 gcaaggtgat gagcggcggg atgcccgccg ccgcgttcgg cgggcgcgcc gaggtgatgc
615781 agcggctggc gccgctgggg ccggtgtatc aggccggcac gttgtcgggt aacccggtgg
615841 cggttgccgc cgggctggca acgctgcggg ccgccgacga cgcggtctac accgcattgg
615901 acgccaacgc tgaccgcctg gccggcctgc tctccgaggc actgacggat gccgttgtgc
615961 cacaccagat ttcgcgggca ggcaatatgc tcagtgtgtt cttcggcgaa acaccggtga
616021 ccgacttcgc gtccgcgcgg gccagccaga cctggcgtta tccagcgttc tttcatgcca
616081 tgctggacgc cggtgtctac ccgccgtgca gtgccttcga ggcatggttc gtctcggccg
616141 ctttggacga cgcggcgttc ggccggatcg ccaacgcgct gcccgccgcg gcccgagcgg
616201 cggcccagga aaggcccgcc tgatgcccga ggaaacccaa gtccacgtgg tgcgccacgg
616261 tgaggtgcac aaccctaccg gcatcctgta cgggcggctg cccggattcc acctgtccgc
616321 aaccggcgcg gcgcaggccg ccgccgtcgc cgacgcgctg gccgaccgcg acatcgtcgc
616381 ggtaatcgca tcgcccttgc agcgtgccca ggagaccgcc gcgcccatcg ccgcccggca
616441 tgaccttgcg gtggagacag acccggatct gatcgaatcg gccaacttct tcgagggccg
616501 ccgcgtcggc cccggtgacg gggcatggcg cgacccgcgg gtgtggtggc agctgcgtaa
616561 cccgttcacc ccgtcgtggg gtgagcctta cgtggatatc gctgcccgaa tgacgaccgc
616621 ggtggacaag gcacgtgtcc gcggcgccgg ccatgaggtg gtgtgcgtca gccatcagct
616681 gccggtgtgg acgctgcggc tgtatctgac cggtaagcgc ctctggcacg atccgcgccg
616741 tcgggactgc gcactggcct cggtgacgtc gttgatctac gacggcgacc gcctggttga
616801 cgtggtgtat tcgcagccgg cggcgctttg accgcgccgg cgacgatgca gagcagagcg
616861 accagaagga gcggcgcttt gaccatgcgc cggctggtga tcgccgcagc ggtatcggca
616921 ttgctgctca ccggctgttc cgggcgcgac gccgtcgccc aaggcggcac gttcgaattc
616981 gtctcgcccg gcggaaagac cgacatcttc tacgatccgc ctgccagccg cggccgcccg
617041 ggcccactgt ctgggccgga gctggcggat ccggcgcgca gtgtgtcgct ggacgacttc
617101 cctgggcagg tcgtcgtcgt caacgtgtgg gggcaatggt gtgggccgtg ccgggccgag
617161 gtcagccaac tacagcgggt gtatgacgcc acccgaggtg cgggtgtgtc gttcctcggg
617221 atcgacgtgc gcgacaacaa ccgccaggcg ccccaggact tcatcaacga ccggcatgtg
617281 acgtacccgt cgatctatga cccggcgatg cgcaccttga tcgcattcgg tggcaaatac
617341 cccaccagcg tcattccgtc cacgctggtg ctggaccgtc agcaccgggt cgcggcggtg
617401 tttctgcgcg aattgctggc tgcggacctg cagccggtgg tcgagcgggt ggccgaggag
617461 gagccgtcgg gtcgggctcc ggtgggggcg caatgaccgg gttcaccgag attgccgcgg
617521 tggggccact gctggtggcg gtgggggtat gtctgctggc tggtctggtg tcgttcgcct
617581 caccatgtgt ggtgccgctg gtgcccggct acctgtcgta tctggcggcc gtcgttgggg
617641 tggacgagca gctgccggcc ggcgtcgtca aacccccggt ggctgcccgc tggcgggtcg
617701 ccggatcggc ggcgctgttc gtggcggggt tcacgacggt gttcgtgctg ggcaccgtcg
617761 ccgtcttggg catgaccacc acgctgatca cgaatcagct gctgctgcag cgggtcggag
617821 gcgtgctgat cgtcgtcatg ggcctggtgt tcgtggggtt catcggagcc ctgcagcgcc
617881 aggcgaggtt cacgccgcgc cagttgacga gcgtagcggg ggcgccggtg cttggcgcgg
617941 tgttcgcgct cggctggaca ccgtgcctgg ggccgacgct gaccggggtg atcaccgttg
618001 cctcggccac cgagggtgcc agcgtggcgc gtgggatcgt gctggtgatt gcctattgcc
618061 tggggctggg gattccgttc gtgcttttgg cgttcggttc ggcgtgggcg gtggcgggcc
618121 tgggctggct gcgccggcac accagggcca tccagatctt cggcggggcg ctgctgatcg
618181 cggtcggtgc cgcgctggtc accggggtgt ggaacgacgt cgtgtcgtgg ctgcgcgacg
618241 ccttcgtttc cgacgtgagg ttgccgattt gagtgggcag ggtgccgcgc aaaaggcgcg
618301 caacatgtgg cggtcgttga cgtcgatggg caccgcgctg gtgctgctgt ttttgctcgc
618361 gctggctgcc atacccgggg ccctgctgcc gcagcgtggc ctcaacgccg ccaaggtgga
618421 cgactacctg gccgcgcacc cactcatcgg tccgtggctg gacgagctgc aggccttcga
618481 cgtgttctcc agcttctggt tcaccgccat ctacgtgctg ctgttcgtgt ccctcgtcgg
618541 ctgtctggcc ccgcggacga tcgagcacgc ccgcagcctg cgggctacac cggtcgccgc
618601 cccgcgcaac ctggcccggc tgcccaagca cgcccacgcc cggctggccg gcgagcccgc
618661 cgccctggcc gccaccatca cgggccggct gcgcggctgg cgcagcatca cccggcaaca
618721 aggcgacagc gtggaagtct ccgccgagaa gggctacctg cgcgagttcg gcaacctggt
618781 gttccacttc gcgctgctgg gtctgctggt ggcggtggcc gtcggcaagc tgttcggcta
618841 cgagggcaac gtgatcgtga tagccgacgg cggacccggt ttttgttcgg cgtcgccggc
618901 cgcgttcgac tcgtttcgcg ccggcaacac cgtcgacggc acgtcgttgc acccgatctg
618961 tgtgcgggtc aacaacttcc aagcgcacta cctgccgtcc gggcaggcca cctcgttcgc
619021 cgccgacatc gactatcagg ccgacccggc cactgctgac ctgatcgcca acagctggcg
619081 gccctaccgg ctgcaggtca atcacccgct gcgggtcggc ggcgaccggg tgtacctgca
619141 gggccacggc tatgcgccca ccttcaccgt gacgttcccg gacgggcaga cccgcacgtc
619201 gaccgtgcag tggcgacccg acaacccgca gaccctgctg tcggcgggcg tcgtgcgcat
619261 cgacccgccg gccggcagct accccaaccc cgacgagcgt cgcaaacacc agatcgccat
619321 ccagggcctg ctggctccca ccgagcagct cgacggcacc ctgctgtcgt cgcgtttccc
619381 cgcgctcaat gccccggcgg tggccatcga catctaccgc ggcgacaccg gcctggacag
619441 cgggcggccc cagtcgttgt tcaccctgga ccaccggctg atcgagcagg gccggctggt
619501 caaggaaaag cgggtcaacc tgcgcgccgg tcagcaagtc cgcatcgacc aaggcccggc
619561 ggccggcacg gtggtccggt tcgacggcgc ggtgccgttc gtcaacctgc aggtctccca
619621 cgaccccggc cagtcctggg tgctggtctt cgcaatcacg atgatggcgg gactgctggt
619681 gtcgctgctg gtgcgcaggc gccgggtgtg ggcgcggatc acgccgacga ccgcgggtac
619741 ggtaaacgtc gagctgggcg gcctgacgcg caccgacaac tccgggtggg gcgccgagtt
619801 cgagcggctg accgggcggt tgctggcggg ttttgaggcg cggtccccgg acatggccga
619861 agcggccgca gggaccggaa gggacgtcga ttgaacacgc tgcacgtcaa cgtcggcctg
619921 gcccgctact ccgactgggc gttcacctcg gccgtggtgg cgctggtggt cgcgctgctg
619981 ctgctggcgt tcgagttcgc ccaggttcgc ggtcgcggac tcgcgccgct ggccgtgccg
620041 gccggatcgg tggccaccga tagcgctacc cctgggatcg tggcggacca acggcaccgg
620101 ccgttcgacg aacgcgtcgg gcggggcggg ctggccgtcg cctatctggg catcgggcta
620161 ctgctggcgt gcgtcgtgct gcgcggcctg gccacccagc gggtgccgtg gggcaacatg
620221 tacgagttca tcaacctgac ctgcttgtcc gggctcatcg ccggcgcggt cgtgctgcgc
620281 cgtgcgcgat accggccgct gtgggtcttc ctgctggtcc cggtgctgat cctgctcacc
620341 gtgtccggac gctggctcta cgccaatgcc gccccggtga tgccggcact gcagtcctac
620401 tggctgccca ttcatgtgtc ggtggtcagc ctcggttctg gggtattcct ggtcgccggt
620461 gtcgccagca tcctgttcct tgtgcgcaca tcgcggctgg gtgagccaac cggtgaaggc
620521 gcgctggcgg gtatggtgcg gcggctcccc gatgcccaaa ccctggacgg aatcgcctac
620581 cggaccacga tcttcgcctt ccccgttttc ggcttcgggg tgatattcgg tgccatctgg
620641 gccgaggaag cctggggccg ctactggggc tgggacccca aggagacggt gtccttcgtc
620701 gcgtgggtgg tgtacgcggc gtacctgcac gcgcggtcaa cggcgggttg gcgggaccgc
620761 aaggccgcct ggatcaatgt cgccggcttc gtggccatgg tcttcaatct gttcttcgtt
620821 aacctggtga ccgtcggcct gcactcgtat gcgggcgtgg gctgaccgtt cgtctgcaac
620881 cgacccgagg accgcagcaa gggggagtgc tggtgaccga gcatccgagg acgggcgtgg
620941 gagcccccga tagcggcaac ggcggcacgg atcatccgac cgtgcagttg ccgcccgtgc
621001 catccgtggg ggcaccaccg gctgcggccg gtggtgaaac accgactagg tcagttgcgg
621061 gattccgcac ccagcggctc gacccgacgg cctacggcgc ctactacagc ggccccgatg
621121 agggcccggc cagcccggct gaaaggccgc cgtatcgtct cgagccggtg ccccatacgc
621181 cgtatccgga actggccacc accacgctgc tgaggccggt caagccgcca ccgtcggaag
621241 gctggcgtcg gttgctctat ctgctgtcgg gtcggctgat caacgccggg gaaggccctc
621301 gggccgcgca cctcaacgac ctggtcgctc aggtcaaccg cccgctgcgc ggctgctacc
621361 ggatcgcggt gttgtcgttg aaagggggtg tcggcaagac cacgatcacc gcgaccctgg
621421 gggccacctt tgccgacctg cgcggtgacc gggttgtcgc ggtcgacgcc aatcccgacc
621481 gcggcacact gagccaaaag gtcccgctcg agacgccggc cacggtgcgg cacctgctgc
621541 gcgacgccga cggcatcgag cgctacagcg acgttcgcgg ctacacatcg aagggaccca
621601 gcgggctgga agtgctggca tcggacagtg atccggcctc ctcggacgca ttcagcgccg
621661 acgactacac ccgcaccctg gacattctgg agcggttcta cggcctggtg ctcaccgact
621721 gcggtaccgg gttgctgcac tcggcgatgt cggcggttct gcctaggtcc gacgtactgg
621781 tcgtggtcag ctcggggtcc atcgacggcg cccgcagcgc cgcggcgacg ctggactggc
621841 tgcaggccca cggccacgac gaccaggtgc gcaactcgat cgccgtcgtc aacgcggtgc
621901 ggccgcgcgc gggcaaggtc gacgtgggca aggtcgtcga gcacttctcc aggcgttgcc
621961 gtgcggtgcg cgtggtgccg ttcgacccac acctcgaaga aggcgccgaa atcgcgctgg
622021 atcggttgcg gcgggagacc cgcgaagcgc tcaccgaact ggcagcggtg gtggccgctg
622081 gattccccgg cgacccgcgg cgctgcaaac cgagcttcac ctaggaacgg ttattgtccc
622141 cgtgccccaa ccgccgcagg aactctggat cgtcgtcggg cccgatgacg cgagtcttgg
622201 gccggttcat ctgtgcccgt gcagcgcgcc agccaaggta gatcagcgtc gccaaaatca
622261 gcacgaggag caggtagagc actcgacacc tccttggacc gaatataccc gcgccgtagg
622321 ctcaggctgt gtcagaagcg cctaacgaca agaccactcg gggtgttgtc gacatactgg
622381 tctatgcgac ggcgcggctg ctgctggtgg tggcggtcag cgcagcgatt ttcggggtcg
622441 cgcgactgat cgggttgacc gaattccccg ttgtcgtggc cacgctgttc gggctgatca
622501 tcgcgatgcc gttgggcatt tgggtgttca gcccgctgcg gcggcgcgcc acggccgcgc
622561 tcgcggtggc cggtgagcgt cggcgcgccg agcgggaacg gctgcgggcc cggctgcgtg
622621 gcgagtcgct acccgaagaa cagtgagcgc ggggcgcctg gtagtcggca ttgtgcacaa
622681 gtgggttggg cattcagcac agtgtttgcg ctgatcgtgg cgattcgcct cggccgcgat
622741 tggcggctcc taacgttggc tgcaccgggt gtgggttgcg ggaaggtgtg cgatgtctaa
622801 tttgctggta accccggagc tggtggcggc tgcggcggcg gatttggcgg gtattgggtc
622861 ggctatcggt gcggccaatg cggcggccgg ggccccgacg atggcgctgt tggccgccgg
622921 tgccgatgag gtgtcggcgg cggtggcggc cgtgttttcc tcctacgccc agcaatatca
622981 ggcgctgagc gctgcggcgg cggcgtttca cgaccagttc gtgcgggcgt tggccgcggg
623041 tgcgggtgcg tatgcgggcg ccgaggccgc caacgtggag cagcagttgc tgaacgcgat
623101 caatgcgccc accctcgcgt tgttggggcg gccgctgatc ggcaacggcg ccgacggggc
623161 ggccgggacc ggtcaggccg gcggggcagg cgggctgttg tacggcaacg gcggtaacgg
623221 cgggtcgggt gcggccgggc aggccggcgg ggccggcggc gccgccgggc tgatcggcca
623281 cggcgggacc ggcggggccg tcaccggggt cagcaccacc ggcgggccgg gcggtcacgg
623341 cggtgacgcc ggcctgtacg ggtttggcgg ggccggtggc gcgggtgggt tcggccagag
623401 cggggcggcc ggcggggccg gtggggccgg tgggtggttg tacggcgacg gcggcgacgg
623461 cggcgcaggc gacaacggcg gtaacgagtc cggcaccggc gtcagtgccg ttgggggtgt
623521 gggtggggcc ggtggtgctg gtgggttgtt gttcggtaac ggcggcgacg gcggcgtcgg
623581 cggcgacggc ggcgacggca gcagcaccca ggattccggt ggtgatgggg gtgcgggtgg
623641 ggccggtggt gctggtgggt ggttgcttgg taatgggggg gccggcgggg ccggcggggc
623701 cgcctcaatc aaggttgcca ctggtgggct gggtggtgat ggtggcgatg ccgggctgtt
623761 cgggtttggt ggggacggcg gctggggcgg acgcggagtg gatgctcgat tcggtgcggc
623821 tgggggtgcc gctggggccg gcggtgcggg cgggtggttg tacggcgatg gcggcgccgg
623881 cggcgtcggc ggtgtcggcg gtgctgtctt cagcctttcc tccggtgacg gcggggccgg
623941 cggggccggt ggcggtggtg ggtggttgtt cggtaacggc ggcgacggcg gcgccggtgg
624001 cggcggcggt ggccgcttcg gcagcggcag cggtgccggt ggtgatgggg ctgtcggtgg
624061 ggccggtggt gcgggcgcgt ggttcggcaa cggtggcgcc ggcggcgtcg gcggcggcgg
624121 tggccgcggc accaccgcca tcggtggcga cgggggtgcc ggtggggccg gtggtgcggg
624181 tgggtggttg tacggcgacg gcggcgccgg cggtgccggc ggcggtggtg gccgcggcgg
624241 caccggcaac gatggtggcg acggcgggga cggcggccgc ggcggtgatg cccagctgct
624301 tggcaacggc ggtgacggcg gggccggcgg ggccggcggg cccgccgggt tggcgcttcc
624361 cccggggccg gcgcggccgg cgggggcggc ggtgccggcg gttcgctgtt cggcagcccc
624421 ggcacgaccg gcccgcacgg ctgatccctg gctagcgccg atcttcgcgc gctcaaccct
624481 tcggcattcg caccacctgg gcggcatagc tcagaccggc gccgtagccg atcaacaggg
624541 ccagatcgcc gggcttggcc gcgccggtcg tcagtaattc ggccatcgcg agcggaatgg
624601 aggccgccga ggtgtttccg gtgtgctcga tatcgttggc gaccaccgcg tcgggccgca
624661 actgcaggtt cttgaccagc agctcgttga tgcggctatt ggcctgatga gggacgaaca
624721 cgtctatctg gtcgggtcgc accccggcgg cgtccatcgc gcgccgaccg acgtcgccca
624781 ttttgaacgc tgcccaacgg aagaccgcgg gaccttcgag ccgcacaaac gggcgtgggc
624841 cgctgggatt ctgggcgaaa gtgatccagt cgatgtcctg ccgtatggca tcggcctgtt
624901 cgccgtcgct acccgccacg gttggtccaa tgccttgaaa cggtgtctcg cccaccacca
624961 ctgcggccgc gccgtcggcg aagatgaagc agttgccgcg gtcgtacatg tctatcgtgg
625021 gggacagttt ttccgtgccg accaccagca tcgtggccgc acctccgccc cggatcatgt
625081 cggccgctgc gccaagcgca tatccgaatc cggcgcaccc cgccgaaaga tcgaacccga
625141 gtatgccctt ggcgcccagc gacgccgcga ccattggggc ggccggcggg gtttgcagga
625201 aatgggtgtt ggtggtgacg atcacgccat cgatgtcggc cgccgacagg ccggcgttcg
625261 acagtgcccg tcgacaggcc tcagtcgcca tggaagccgc cgactcgtcg tcggcggcga
625321 atcggcgggt cttgatgccg gttcgggtgt agatccactc gtcggacgag tcgatgtgct
625381 ggcatatctc gtcgttggtg accacgcgtt cgggccggta cgccccgaca ctgagcagcc
625441 cgacgctcct ggcgccgctg gtcgtggcga tctccgtcat acccgtccta tctgttctcg
625501 tcgagtgtgc acctacggcg acgacacgcc gacggagccc gccctgagtg cacgttcgaa
625561 gttagctcaa ctgaccaaac gccaatgccc ccgccaccgc caacgcccac accagcatgg
625621 ccagcccagt gtcacgcagt accgggatca gctcgcgccc gccgcgcccg gatcgcaccg
625681 gtccggcagc gcgcagcgcc aaaggcgcgg ccaccaagcc caccacacac cacggcgtgg
625741 ccagcattag cacgaacgtc agcaccccgg cgaccgccag caggccctgg taaagcatcc
625801 gggtccgggc gtctcccagc cgcaccgcca gcgtgatctt gtcggcccgc gcgtcggtgg
625861 ggatgtcgcg caggttgttg gccaccagca ccgagcacga caacgcaccc gttgctaccg
625921 cctgtgccag ccccacccag tccacccgca atgcctgcgt gtactgggta ccgagcacgg
625981 cgaccggccc gaagaacaca aacaccgcca gttcgccgaa gcccgcatag ccgtagggtt
626041 ttgacccgcc ggtgtagagc caggccccgg cgatgcagat cgcacccacc gcaatcagcc
626101 acggcgcgct gagcagcgcc aaaaccagcc cggccagcgc accgagcgcc aggctcgtca
626161 tggcagcggt cagcaccgag cgcggggtcg ccagccgcga gcccaccaac cgcaccggac
626221 ccaccctgtc gtcatcggtg ccgcggatgc cgtcggagta gtcattggcg taattgaccc
626281 caatgaccag cgccaccgca acagccagtg ccaacagcgc tttccaccac acggccgcgt
626341 gcagccaggc cgcggcgccg gtgccggcaa ccactggcgc gatcgcgttc ggcagcgttc
626401 ggggccgcgc gccggagacc cactgtgcga aactggccac cagggcatcc tgccctatgc
626461 acaacaatgg gcgcatgctc ggagtgatcg gcggcagcgg cttctacacc ttctttgggt
626521 cggacacccg cacagtcaat tcggacaccc cctacggtca acccagcgcc ccgatcacga
626581 tcggcaccat cggggtgcac gacgtcgcgt tcttgccccg ccacggcgcc catcaccagt
626641 actcggcgca cgccgtgccg tatcgggcca acatgtgggc gctgcgcgcg cttggtgtgc
626701 ggcgggtctt cgggccgtgt gcggtcggca gcctggaccc tgaactcgag cccggcgcgg
626761 tcgtggtgcc cgatcagctg gtcgaccgca ccagcggccg cgccgacacc tatttcgact
626821 tcggcggtgt ccatgccgcc ttcgccgatc cgtactgccc cacgctgcgg gccgcggtga
626881 ccggcctgcc cggtgttgtc gacggcggca ccatggtggt gatccagggt ccgcggtttt
626941 ccacccgcgc ggaaagccag tggttcgccg ctgccgggtg caatctggtc aacatgaccg
627001 gctatcccga ggcggtgctg gctcgcgaac tcgaattatg ctacgcagca atcgctttgg
627061 tgacagatgt ggatgccggc gtcgctgctg gcgatggcgt gaaagccgcc gacgtgttcg
627121 ccgcattcgg ggagaacatc gaactgctca aaaggctggt gcgggccgcc atcgatcggg
627181 tcgccgacga gcgcacgtgc acgcactgtc aacaccacgc cggtgttccg ttgccgttcg
627241 agctgccatg agggtgctgc tgaccggcgc ggccggcttc atcgggtcgc gcgtggatgc
627301 ggcgttacgg gctgcgggtc acgacgtggt gggcgtcgac gcgctgctgc ccgccgcgca
627361 cgggccaaac ccggtgctgc caccgggctg ccagcgggtc gacgtgcgcg acgccagcgc
627421 gctggccccg ttgttggccg gtgtcgatct ggtgtgtcac caggccgcca tggtgggtgc
627481 cggcgtcaac gccgccgacg cacccgccta tggcggccac aacgatttcg ccaccacggt
627541 gctgctggcg cagatgttcg ccgccggggt ccgccgtttg gtgctggcgt cgtcgatggt
627601 ggtttacggg caggggcgct atgactgtcc ccagcatgga ccggtcgacc cgctgccgcg
627661 gcggcgagcc gacctggaca atggggtctt cgagcaccgt tgcccggggt gcggcgagcc
627721 agtcatctgg caattggtcg acgaggatgc cccgttgcgc ccgcgcagcc tgtacgcggc
627781 cagcaagacc gcgcaggagc actacgcgct ggcgtggtcg gaagcgagtg gcggttcggt
627841 ggtggcgttg cgctaccaca acgtctacgg ccccggcatg ccgcgcgaca ccccctactc
627901 cggagtggcc gcgatcttcc gctcggcggt tgaaaaaggc aagccaccaa aggttttcga
627961 agacggcggc cagatgcggg acttcgtgca cgtggacgac gtggccgcgg cgaacctcgc
628021 cgcggtgcat ctgggtgaag cggaccgcga cgggtttacc gcggtcaacg tctgttccgg
628081 gcgccccatc tcgatccttc aggtggcaac cgcgatatgc gacgcccgcg gtggctcgat
628141 gtccccggcc atcaccgggc actaccgcag cggcgacgtg cgccacattg tcgccgatcc
628201 cgcgcgggcc gcccgcgtgc tcgggttccg cgcggccgtc gatccaggcg aaggactgcg
628261 tgagttcgcg ttcgcgccgc ttcgctgacc gctcgagcta cgacgagtgg tccggcggcc
628321 ggtagatctt cggccgcact gggtgcgtcg acccagctga cctgaaaatc cggggggatc
628381 cagcaggccg ggacagcgcc ggggtgtgcg ggggttgcgg cagctggcgc agcctgccga
628441 tgacgatggc cgccgcgagg atgctgagcg ccaggccgca cagcaccaca tcgaaggtgc
628501 tggtgatctg ctgggcaaga tcgtttccgt agacggggtg agccgacccg cccgaagatg
628561 cctggaatcg cggagccagg acgacgccga cgatgacgcg cgaaacggtg aatgtgcata
628621 gcaatccgca cagcgacgag atcagcctcg cgggcagggc ctcggtcgcc atgttgaagc
628681 gaagccagat cgctaggacc gcggtggcca gatcgaacgc agccagcgcc atgctgtcgt
628741 agcgcgagaa cggataattc aacagcaccg cgacgacgag gtcggtcaac cgcatcgcta
628801 ccgagcccag gcaccacacg gcgatgagca gcaagccgtt tcgggacgct gcccgccaca
628861 cggttttgtc gatcggtggc gcgttcgggg acctgaacag ggtcagcggc gcacacattg
628921 ccgcggccgc ggcccacacc agataaccct cgtatcccac gccggccgtc gacgtgtttt
628981 gggcaatgcc gtggaacgcg tcgatctcgc ggccgatggg aaggctccac acgatggacc
629041 cggcgatcag ggtggagcca cccagcgcca cggttgagag cgcttcggcc gctgtaggcc
629101 gaagcagcca ccgggacgcg accagcacgg cggccagggc taccacgccg tacaccaccg
629161 ccgtgtcgat gaccgcgagg ttctgtttgc caaaaccgga cgcgccggcc gcgggctcca
629221 acgcgtacct gacccgccag ctcaggttga aaccggtgct gagggccgca cccaacatag
629281 acgcgtagcc gaggaactgg gtggcccgca gccacctgct gtggctgccc tcatcggtgg
629341 tagcgccggt tagcgccggt tgcgcgctca acagcgcgcc ggtgatcccc agccatcccc
629401 ccggcccgac accaccgggc acgtggacgg tgccgccgag tcgaatcgtc tggatcgcgt
629461 cgaacaccac gaaggccagc accagcagca gataggggac gttgaggccc aggcgaagct
629521 gtgagcgcct cccggcgaag gtcacggcaa gcgatgccaa agagagcgat gtcaccgcca
629581 gcagcaaccc gaacacggtc ttgctgctgt ccgggattcg gaaaccgaaa tacaggttcc
629641 atgggaaaaa cagcgcaccg atgagcaggg caccagcggc caagtcgcgg acgacctcgc
629701 gtcgtcgggt gtcgtcgctg ctcaggccca cgatgccccc cgggaatcaa gaacggttgg
629761 cgccgagtcg gtcctgtggt ggcgtgggtg cacccggccg ggccgactgc gttgctcgct
629821 tgcgaacata gtctccgttc cgacgacgcg gcagtggcgc agaacacgcg gttgggcgga
629881 tctcgtttgc ccggtgaccg tcccgctgtt tgcgaacccg gttacgctgc ggtcataggc
629941 gaacgctgtc gccgaattac cgatactgcc gacggtatcg cagtgtaacg atgccgggac
630001 attgctggtt gtggggtagc cagccgaagg agagccgcga tggacgtcgc tttgggggtt
630061 gcggtcacgg atcgggtcgc gcgtctggcg ctggtcgact cggctgcgcc cggcaccgtg
630121 atcgaccagt tcgtgctcga tgtggccgag cacccggtcg aggtgttaac cgagaccgtg
630181 gtgggcacgg atcggtcatt ggccggcgaa aaccaccggc tggtcgctac ccggctgtgt
630241 tggccggatc aggccaaagc tgacgagctg cagcacgcac tgcaggactc cggggtccac
630301 gacgttgccg tgatatccga ggcgcaggcc gccacggcgc tggtcggggc ggcacatgcc
630361 ggctctgccg tgctgttggt gggtgatgag acggcaacct tatcggtggt tggtgacccg
630421 gacgcgccgc cgacgatggt ggccgtcgcg ccggtggcgg gcgccgacgc cacatcgacc
630481 gtcgataccc tgatggcccg gctcggcgac caggccctcg ccccggggga tgtcttcctg
630541 gtgggtaggt ccgccgagca caccacggtt cttgccgacc agctgcgcgc ggcgtcgacg
630601 atgcgcgtgc agactcccga cgaccccacg ttcgcgctgg cccgtggcgc ggcgatggcg
630661 gccggcgccg ctacgatggc gcacccggcc ctggtcgcgg atgcgaccac ttcgctcccc
630721 cgggccgagg cggggcaatc gggttctgaa ggcgagcagc tggcgtactc gcaggccagc
630781 gattacgagc tgcttccggt cgacgaatat gaggaacacg acgaatacgg ggcagccgcg
630841 gatcgctcgg cgccgttgag ccgacggtcg ctgctgatcg gcaacgctgt cgtggccttt
630901 gcggtgatcg gtttcgcctc gctggcggtg gcggtggcgg tcaccatccg accgaccgcg
630961 gcctcaaaac cggtagaggg acaccaaaac gcccagccag ggaagttcat gccgttgttg
631021 ccgacgcaac agcaggcgcc ggtcccgccg cctccgcccg atgatcccac cgctggattc
631081 cagggcggca ccattccggc tgtacagaac gtggtgccgc ggccgggtac ctcacccggg
631141 gtgggtggga cgccggcttc gcctgcgccg gaagcgccgg ccgtgcccgg tgttgtgcct
631201 gccccggtgc caatcccggt cccgatcatc attcccccgt tcccgggttg gcagcctgga
631261 atgccgacca tccccaccgc accgccgacg acgccggtga ccacgtcggc gacgacgccg
631321 ccgaccacgc cgccgaccac gccggtgacc acgccgccaa cgacgccgcc gaccacgccg
631381 gtgaccacgc cgccaacgac gccgccgacc acgccggtga ccacgccacc aacgaccgtc
631441 gccccgacga ccgtcgcccc gacgacggtc gctccgacca ccgtcgcccc gaccacggtc
631501 gctccagcca ccgccacgcc gacgaccgtc gctccgcagc cgacgcagca gcccacgcaa
631561 caaccaaccc aacagatgcc aacccagcag cagaccgtgg ccccgcagac ggtggcgccg
631621 gctccgcagc cgccgtccgg tggccgcaac ggcagcggcg ggggcgactt attcggcggg
631681 ttctgatcac ggtcgcggct tcactacggt cggaggacat ggccggtgat gcggtgacgg
631741 tggtgctgcc ctgtctcaac gaggaggagt cactcccggc ggtgctggcc gcgatcccgg
631801 ccggctatcg ggcgctagtg gtggacaaca acagcaccga tgacaccgcg acggtggccg
631861 cccgccacgg tgcccaggtg gttgtcgagc cgcggcccgg atacggctcg gcggtgcatg
631921 ccggtgtgct cgccgcgacc acccccatcg tagcggtcat cgacgccgac ggctcgatgg
631981 atgccggcga cttgcccaag ctggtcgccg aactcgacaa gggcgccgac ctggtgaccg
632041 gtcggcggcg gccggtggcg ggcctgcact ggccatgggt cgcccgggtg ggcaccgtgg
632101 tgatgagctg gcggctgcgc acccgccacc gcctgccggt gcacgacatc gcgcccatgc
632161 gggtcgcccg gcgagaggcc ctgctggatc tgggcgttgt cgatcgacgc tcgggttacc
632221 cgctggagct gctggtccgg gccgctgcgg cgggctggcg tgtcgtcgaa ctcgacgtca
632281 gttacggtcc ccggaccggc ggcaaatcca aggtcagcgg ttcgctgcgg ggcagcatca
632341 tcgcgatcct ggacttctgg aaggtgatct cgtgagctgc ctgccggtca gcgtgctggt
632401 ggtcgctaaa gcgccggagc cgggccgggt caagacccgg ctggccgcgg cgattggcga
632461 taaggtcgcc gccgacatcg ccgcggccgc actgctggac accctggatg cggtggccgc
632521 tgcgccggtc accgcccggg cggtggcgct taccggcgac ctggactccg cggccgattc
632581 cgcggagatc cgccgacggc ttaagtcctt cacggtattt cggcagcgcg gtgacgcctt
632641 cgccgaccgg ctcgccaacg cacacgtcga cgcggccgac ggctatccgg tgctgcagat
632701 cgggatggac acgccccagg tgaccgccga gctgttggcc gattgtgcac gcctgctgct
632761 tcaaatcccc gcggtgctcg gcctggcgtt cgacggcggt tggtgggtgc tggggatacg
632821 cacgcctact gcggccgagt gcctgcgcgc cgtcccgatg tcacagccag acaccggcga
632881 gctcaccttg aaggcgttgc gcgacaacgg cattgatgtg acgctagtgc agcgtctggg
632941 cgacttcgac atcgtggacg acatcgcgct ggtacgcgat tgctgcgctc cggggagtcg
633001 gttcgcgcag gctacccgcg cggctggact ctgaggccgc gccggcgcat ttgcttacca
633061 gttggtgaag atgatgctgt tcagcagtag ggccccggcg gcgttgaccg ccagccagag
633121 tcggtgcgag cggggcggca gcagtgcggg cgccgcggtc agccaaatgg tgaagggcag
633181 ccagattcgt tcggtctcgg ctttgctcag catgctcagg tcggccaagg cgatggcggc
633241 cagcaccgcc agcagcagca gatggcagcc ggatcgacga ctgatcgcgg cccggtcgaa
633301 tacccggctg agacctgcga cgctgcctaa cccgatagcg cagaccacgc acgccaagtt
633361 tgcccaggac caatagccga acggccgatc tttggcgatc ccctgccaat agcgttgctg
633421 gacaagggta taaccgtcga accaggagaa tccggcaacc gcgaagctca ccgcgaccac
633481 cagcgccgcc agcacggccg gccccagtgc ccgcaggacg ggccgccaat ctgcggcggc
633541 caacaccgcc atccccggca gcacgatcag cacgagcccg tagttgagaa agacacccca
633601 gccgagcagt agccccgctc cggccgccac cagcgccggg aagcgagtgg caccatgcac
633661 cgccaccgcc aacagggcga taccccacgc cgccacaccg gcgaaatacc cgtcggccga
633721 aaccgcgatc cagatcgccg tcggcgccac cgcgacgaat ggtgccgtcc gccgcgccat
633781 ctgctcactg gccagcaccc gcacggcgat cagcaccgcc gccgccgcgc tggatcccac
633841 cagcaggcac accagccccg cccaaccgcc accgcgcagc ccgatccgat ccagccagac
633901 aaacgtcagc agcgcacccg gcgggtgccc ggagacgtga gtcacccagg aattgggctg
633961 gaagtcgaga atccggctgg tgaacgtccg caacgtcgcc gggatgtcgg caatgccggg
634021 cacctgccac aggtactcgt cacgggtggt caatcggccg gcaaagccgc gctgccagcc
634081 gtcgatcatc gccagtgaga acgcccaggc ggcggcggtg gcccaggtgc tcagcgtcag
634141 cacccgccag gggagccggt gcgccactac cggcccccac gccacaacgg ccactgcggt
634201 aagaaccgcc ggggccgtgc cccagccaac atgggcgtcc cagtagccga agatcggcgc
634261 ggcgccggcg cgcgtggcaa accgctccaa gccgatatcg gatcgcggtt tgattcccag
634321 gttcaaccgc ggcagtacga acgcggcgcc gaccaggaca aacccgatcg cgacggccaa
634381 tccctcgcgg cgaccgatcc tcacgaccga tcagcctatt gatcggcttc accggcgaac
634441 cggcgcacca acgctgcccg gtccaccttg ccgatgccgc gtcgcggtag cacgttcacg
634501 acatgtagct ctcggggcgc ggcggtgacg tccagggtgc gcgcgacatg cgcccgcagc
634561 gcttctagcg ttggtggtgg gcatccgtcg ccgaccacaa tcgcggcgac cactcgctga
634621 ccgagtcggt cgtcggcaag tccaaaaacc gcgcagtcac gcaccgcagg gtgggtgccc
634681 agtgcggcct ccactggctg cggcagcacg gtgaatccgc ccgtgctgat cgcttcgtcg
634741 gctcggccca gcacggtcag cacacccgaa tcacccgatt caagggcgcc aaggtcgtcg
634801 gtgtgaaacc agcctggctc ggcgaacgga tcgggcgaga ccgggttgcg atagcccttg
634861 gccagggtcg caccgccgat agctatgcgg ccgccggcca gcaccctcag ccggaccccg
634921 tcgagcggaa cgccgtcgta gacacagccg cccgaggtct cgctcatgcc gtaggtgcgc
634981 accaccgtga tgccggcggc ggccgcggcg tccaggatgg gccggggggc cggcccgccg
635041 ccgatcagca ccgcgtccaa ttcggccagc gcggccgtgg ccgccgggtc ggtaagtgcc
635101 ttggccaact gtgcggcgac cagcgacgtg tatcgccggc cagaacccaa tctctttatc
635161 gcgttgggta attcggtgac atcgaatccc gcggagacgt tcagttcgac aggaactgat
635221 ccggcgatca cgctgcgcac cagcaccgcc agcccggcga tgtgatacgg cggcacagcc
635281 aacagccagc tgcccggtcc gccgagccgg tcgtgggcgg ccgaggcgct ggcggtcaag
635341 gccgccgcgg tcaacatggc gcccttgggc ggtcccgtgg ttcctgacgt cgtcactacc
635401 agggcgacgt cgtcgtcaat ctgctcgccc actcgcaaag cgcccagcaa ggactcatgc
635461 tgggtgggca ccgcgaccaa tgccgggtcg ctgccaccca gcactcgttg cagggcaggc
635521 agcagcagcg cggtagcaga accggccggg acgtgcagcg cacgcaggat ggctatgcgt
635581 gctcctcgcg gtcgcggacg tcatcgagtg gccatccctg ggcggccaac cgcgcccgga
635641 cgcgctcaac atcctccggt gacggcaact cgtcggtgaa atgggtgatc accacgccga
635701 tgtcgatctg gtcgaagtca ccgagtcgca tcagttcgtt agccaccgcc ttgacctcat
635761 cgtggctcag ccggcggcaa agcagggcga gcaccgcaaa ggagtcggtc ggcggaatgc
635821 cctcgggata tcccgcgcgc aaccacgcga cgatcgaggt gagaaaccgg ttcacgctgt
635881 tatatcttcc cgtcggggcc gtcgccaaac cctatgtcgc ggccatctgc gactctactt
635941 gggtgtggcg cccaggaagg cccagccggt gtgatgcgcg atgaagtcac gggcgatata
636001 cagcactcca atgatgacta ccgcaagcac cagcgcgaag atcgcccaac tgacggcaac
636061 cagcagcggg cgccggcgcg cggtggcgtc ggcaccgtcg ccggcggcct gcagccgcac
636121 gcccaccgcg aacaggcccg gtagcagcgc gccggctagc agactgaaga tcaggatctt
636181 cagggtggcc gtgtagttga accaggcact cacggggcgt tcctcgtggt gacgccgaac
636241 tgtggtgctc ggtggttcgg tgggggagtc ggagccggcg gtgcaggcac cggcggcctc
636301 tgatccgcaa gcggctgcgc acccgcttcc aggccggccg tcaggttgcc ttcccagtcg
636361 gcgttgacgt tggtgtggtc gatcggcgcc ctgcgcgacc gcagccagat ggcggtggcg
636421 gtcagccaca acagtgcgaa accgaggatc gcaccggggt agccaccgat gaaatgcacc
636481 agcccgtagg tgaaggcccc gaccagcccg gccaacggga gcgtcaccag ccacgcgacc
636541 accatgcggc cggctacccc ccagcgcacc tcggcgccgg gcttgccgac gccgctgccc
636601 agcacggacc cggtcgcgac ctgcgttgtg gacagcgcat agccgaagtg cgcggacaac
636661 agaatgacgg cggccgatga cgactcggcg gccataccct gcggtggttt gatctcgacc
636721 agccctttgc ctagggtgcg gatgatgcgc cagccaccca ggtaggtacc ggcggccatg
636781 gccacggcgc aactcacgat cacccacagc ggcggcaccg atgccgtcgt gctgaccgcg
636841 ccgtaggaca tcaacgccag gaagatcacg cccatcgtct tctgcgcgtc gttggtgccg
636901 tgcgccagcg agaccagcga cgccgagccg atctggccgc gccggaaacc gcgttccgta
636961 cgcttttcgg caaccccgcg cgtcgtccgg tagaccagcc aggtgccgac tgctccgacc
637021 agcgtggcca gcagcgcggc taccacggcc ggcacgatca ccttggacac cactccgctc
637081 cagatcaccc cacgcaggcc gacggcggca attgtggcgc cgacgatgcc gccgatcagc
637141 gcatgtgagg aactcgacgg aatgcccagc aaccaggtca acaggttcca gacgatcccg
637201 ccgaccaggc cggcgaacac caactccagc gtcaccagat tcgcgtcgat cagacccttg
637261 gcgattgtgg ccgccacggc ggtggacaaa aacgcaccga tcaggttcag cacggcagga
637321 agtgctaccg ctacccgcgg tgccagggcg ccgctggcaa tcgaggtcgc catggcgttt
637381 ccggtgtcgt ggaacccgtt ggtgaagtcg aacgccaatg ccgtcacgac gacaatgagc
637441 aaaaggaaca actgaaggtt cacagggcct gattctgctg gtcgggatat tgcgttgtcg
637501 atcaaacgag tacgcgaaat gcgggtgtat ctcgactcgt cgtcagatgt taccaatcac
637561 gtaacccagc gttttgcgga gttcacgccc gggtgtctgt acgcagcggg tgaccctcgg
637621 gaacctcgac gaatatcagt gtgatcccgt ctgggtcggt cacatgcatc tcgtgcaggc
637681 cccacggttc gcggcggggc tcgcgagcga tcgacacgcc tcggctgacc agctcggtct
637741 gggtagcctc gaggtcgcgc acctgcagcc acagcgcgcc gggaaaaggt ccccgcgaat
637801 ggtccggctc gccgtaaccg gccagttcga gcagtgactg accggcgaaa aacactgtgc
637861 cggccccgta ttcacgggca atcgccagcc cgatctggtc acggtagaag ctcagcgacc
637921 gctgatagtc cgccggccga agtagcatcc ggctggccag gatttccatg gccctgtgtc
637981 tatcacgtag cggcacgccg gcggccgagg gtcggcaggc cgggacccgg ttcaagggtt
638041 gagctgttcg ttgcggcgct gcatgagtgc attgacccag cggggaccga tgctgtccag
638101 cgcgttgacg gcgacggcaa cccgaggcgc gatccgcacc ggtcgggtgc gggcggcggt
638161 gaccatccac tcggcggctt ccgcggcggt cagcgccggc agcccgtcgt aggccttcgt
638221 cggcgcaatc atcggagttg ccaccagcgg gtagtacagc gtcgtcgaat gcacgccctg
638281 actaccccac tcggtttcga tgatccggct caccgccgac agtgcggcct tcgatgcgtt
638341 gtacaccgag aacagcggcg aagcctccga caacacgccc caggtggcga cattgatgat
638401 atggccgtcg ccacgctcga gcatcccggg tgcaagcccg cggataagcc gcagcggggc
638461 atagtagttg agcaccatgg tgcgctcgac gtcgtgccag cgttccagcg actcggccag
638521 cggccgccgg atcgaccggc cggcattgtt gatcaggatg tcgatcccgc cgatgcgctt
638581 ttcgacgtct tcgaccagcg cgtcgatcgc ttccatgtcc gagaggtcgc aggggagcga
638641 catcgccgtg ccgccgtcgc cggtgatccg gtccgccacc gcatccagca gatccttacg
638701 gcgcgcgacg gcaaccacga cggcgcggtg cagtccgaac tgtttggtcg cggccgcacc
638761 gatgcctgac gacgcgccgg tgagcaggat gcgcttgccg gtgaggtcga cgggttgcat
638821 cgcgggccgg ttgatcagca gttgcggcga aattggtggc cgcatgccgg ccaatgtgat
638881 ttgttcagtc aaccagcgca gcggtctttt gctcacagct ggggagtcta gttttgccga
638941 gcctgtagtt actgtggtgt cccactcgtc gggcttctgc tcggcaacta cagcctcggc
639001 gaacggccgc gttagaaata gcgcggaaac gggctccagt cggggggacg cttctgtagg
639061 aaggcgtcgc ggccttcgac ggcctcgtcg gtcatgtagg ccaggcgggt ggcctcaccg
639121 gcaaacagtt gctgacccac cagcccgtcg tcgagcaggt tgaacgcgaa cttcagcatc
639181 cgttgcgcct gaggcgattt cgcgttgatc tcggccgccc actgcagccc cactgtctcc
639241 agctcggcgt gttcggccac cgcgttgacc gcgcccatct ggtgcatctg ctcggcggtg
639301 taggtgcggc ctaggaagaa gatctcgcgg gcaaacttct ggccgacctg acgggccaga
639361 tatgcgctgc cgtaaccgcc atcgaagctg ccgacgtcgg cgtcggtctg cttgaagcgg
639421 gcgtactcgc ggctggccag ggtgagatcg cagaccacgt gcaggctgtg tcccccgccg
639481 gccgcccagc cattgaccag acaaatgacc accttgggca tgaaccggat cagccgctgc
639541 acctccagga tgtgcaaccg gccggcgcgg gcgacatcaa ccgtgtccgc ggtgtctccg
639601 ctggcgtact ggtaaccgct gcgcccacga attcgttggt cgccgccgga gcagaacgcc
639661 cagccgccgt ccttcgggga cggcccgttg ccggtcagca gcaccactcc gacgtcgggc
639721 gacattcgtg catggtcgag cacccggtac agctcgtcga cggtgtgcgg gcgaaatgcg
639781 ttgcgcactt cagggcggtt gaacgccacc cgcaccgtgg catcgtcgac gtggcggtgg
639841 taggtgatgt cggtcagatc gtcgaacccg tccacgagcc gccacgcctt ggcatcaaaa
639901 gggttgtcac tcaaggctgt tgaactccgt ccttgttcgc cggctggagc caccacggcg
639961 atctgatccg ttcacccatg cctgccacag taatcatggc cgctgggcgt cagccggacg
640021 gtatggtgcc cggggccttg gtcacatgtg gtcgtgagtt ggcgcccggg cggctttctg
640081 tggagggtca ccgcgtactc gatcatggcg ctgctcgcag ttcatcaccg aaccggcaca
640141 gtgtcgctcg gcaatgcggt ctactcgtgg ggcatgttaa gcgctcaaca gggcggcgcg
640201 cccacctttc tccaagcccc gctggactca gccgatggcg tgagccgagg gccaggcgcg
640261 tgccaatctt tcgtcggtgg tcaacaacac cagacctgcc gtttcggcca gctcgacgta
640321 gagggcatcg gtcaggcgga gggtgtcgcg gcgcgaccac gctccagcaa gcagcgacga
640381 aagaccgtgt cgagtcaccg gcacctgtcg caactcctcc agtgccgcat cgacataggc
640441 aacggtgagt gcgccggcgc gctgcatgcg ccccagcgcc gacaacacct ctgcatcgaa
640501 gtgcgccggc gcgtgcatcg cggtccgagc cagccgcgcg cgcaccgcag agcaccgatc
640561 gctagtgcga gccagtagat ccaccatggc actcgcgtcg acgaccacct gctccggcgg
640621 cgaagtgggc gatgctctca cgcttcgaac tcatcgcgag cggcatcgat cgcacccagc
640681 acgtcatcat gccgagcgcc ggtgcttctg ggttccaacc cctcaagcca cgcatcggtt
640741 gcggagttct ccaactcggc actgatcgcg gcctgagtca gcgccgagac gttcaagccc
640801 cgcgccctgg cgcgctccgc caattcgtcg ggcacataca cgttcaaccg agccatacac
640861 accaatgtac acacaacgat cgttttcgtg cgccggctca acaaggcctt cggcgggttc
640921 tttcgcccgc cgcagaccgc gaaacccgct gtgaaggtgg gttatcccga gcatcgccgg
640981 catatctgca cggcatcggc ggcgtcaagt gcgccggcat cgccaggccg aaggccgggg
641041 tgaagactaa tccagatcag atgcgaggga ccagacttca tgcaacggcc aagccctagc
641101 cgaccgcgcg cccagcgcct tcccagaacc gtgcgcgcac ggccttcttg tccggctttc
641161 ctagaccggt caacggcaaa gagtcgacga ccaccacccg cttgggtgcc tgcaccgatc
641221 ccttgcgttg tttgaccgct gcctggatct cggcggtcat ggcctcgatc gcgggctcat
641281 cgcgggccgc gttggagcgc aacaccacca ccgcggtgac ggcctcgccc cacttctcat
641341 ccggcgcgcc aaccacgcac acctgagcaa ccgccggatg ctcggccacc acgtcctcga
641401 cctcccgggg gaacacgttg aagccgccgg tgacgatcat gtccttgacg cggtcgacga
641461 tgtagtagaa gccatcggag tcctcgcggg ccaggtcgcc ggtgtgcagc cagccgtctt
641521 taaaagtccg cgacgtctcg tctggcagat tccagtaacc gcccgccaac agcggtccgc
641581 tgacacagat ttcgccgact tcgccctgct tcaccggctt gccatgctcg tctaacagcg
641641 cgacgcgggc gaacagcgtc ggccgcccac atgaggtcag ccgcttctcg tcgtgatcgc
641701 ccttggccag ataggtgatc accatgggcg cctcggattg cccgtagtac tgggcgaaga
641761 ttgggccgaa ccgccggatc gcctcggcta gtcgcaccgg gttgatcgcc gaggcgccgt
641821 agtagacggt ttccagcgac gacaggtccc gggtgtgcga atccgggtgg tccagcagcg
641881 cgtacagcat cgatggcacc aacatggtcg ctgtaatgcg ttgctcctca atgattctga
641941 gtacctcggc cgggtcgaac ttcgccagca ctatcatctc gccgcccttg atcaccgtcg
642001 gcgtgaaaaa cgccgcgccg gcgtgcgaca gcggggtgca cattaagaac cgcgggttgg
642061 ccggccactc ccattcggcg agctggatcg aggtcatggt ggcgatcgac tgcgcggtgc
642121 ctatcacgcc cttaggcttg ccggtggtgc cgccggtgta agtcaggccg ataacttggt
642181 cgggtggcag gtcggcggcg accagcggct gcggctggta tttggcggcc tcggcggata
642241 ggtcgactgc cacatgcttg agcgcatcgg gcaccggccc aatggtgagg atttgctgca
642301 gcgagtccac ctgctccagc agagccagtg cgcgctcgac gaacatcggg ttggggtcga
642361 tgatcagtga gctgatgccg gcgtcgttca gcacgtaggc gtgatcggcc agcgagccca
642421 acgggtgcag cgcggtgcgc cgataaccgc gggcctgccc ggcgccgatg atcatcaaaa
642481 cttcaggacg gttgagcgac agcagaccga ccgccacccc ggtgccggca cctagcgcct
642541 cgaatgcctg gatgtactgg ctgatacggt ccgccagctg gccaccggtc agcctggtgt
642601 cgccgaggaa cagcaccggc ttgttctggt ggcgcttgag cgctcccact agcagatggc
642661 cgttgtgggt cgggctgcgc aacagctcgc ccgaacaatc ctggtcacgc atggcgccgc
642721 tctccctcgc tagctggggt acccccaccg catcgcttcg tcccccgcaa gcgggtggta
642781 cccccactgc atcgtcgccg gcggtgctca tctggcaaga ctagaacgtg ttgcaatttg
642841 gatctgccgt gccctcgtaa tctcgaagga tcactacgct tggagcccat ggccgatgca
642901 gacctcgtca tgaccggaac cgtgctcacc gtcgacgatg cgcggccaac ggccgaggcg
642961 atcgcggtcg ccgacggccg ggtcattgcc gtcggtgacc ggtccgaggt tgccggcctg
643021 gttggcgcca acacccgggt catcgatctg ggtgccgggt gcgtcatgcc aggatttgtt
643081 gaggcacacg gccatccgct actggaggcg gtcgtgctgt cggaccggtt cgtcgatatc
643141 cgtccggtga cgatgcggga cgcggacgac gtcgttgccg cgatccgcgg cgaggttgca
643201 cggcgcggcc cggccggcgc ctatctggtc ggctgggatc cgctgctgca gtccggtctt
643261 ggcgagccga cgctgacctg gctcgacagc ctcgcgccga acgggccgct ggtgatcatc
643321 cacaactccg gacacaaggc ttacttcaac tcgcacgccg cctggctcaa tgggctcacc
643381 cgagacaccg cggatcccaa gggcgcgaag tatggccgcg acggcaatgg cgaactcgac
643441 ggcaccgccg aggaaatcgg cgcgattctt ccgcttttgg ccggtgtagc cgaccccagc
643501 aacttcggtg ccatgctgcg cgccgagtgt gctcggctca accgtgccgg cctgaccaca
643561 tgctcggaga tggcttttga cccagggtat cggccgatgg tcgaggcggt gcgcgccgaa
643621 ctgacggtcc ggctgtgcac ctacgagatc tccaatgcgc ggatgtgcac cgatgcgacg
643681 cctgggcaag gtgacgacat gctgcgccag gtgggcatca agatctgggt ggacggctcg
643741 ccgtgggtcg gcaatatcga tctgaccttt ccctacctgg acacccccgc cacccgtgcc
643801 atcggtgtac cgcccggttc ccgcgggtgc gccaattaca cccgtgaaca gttggccgaa
643861 atcgtcgggg cctactttcc gcggggctgg cagatcgcct gtcacgtgca cggcgacggc
643921 ggtgtggaca ccatcctcga cgtctacgaa gaggcactgc gccgcaatcc tcgagacgat
643981 caccggctgc ggctcgaaca cgtcggggcc atccggcccg accaactgcg gcgcgccgcc
644041 gaactcggtg tcacctgcag catcttcgtc gaccagatcc attactgggg cgatgtgatc
644101 gtcgatgacc tgttcggggc acagcgcggg tcccggtgga tgccggctgg atccgcggtg
644161 gccgccggca tgcgtatctc gctgcacaac gacccgcccg tcacaccgga ggagccactg
644221 cgcaacatca gcgtggccgc aacccgggtg gcgcccagtg gccgggtgct ggcaccggag
644281 gagcgcctga cggtcgagca ggcgattcgc gcgcagacca tcgatgccgc ctggcaactg
644341 ttcgctgagg acgcgatcgg ctcgcttcag gtcggcaagt acgcggatat ggtggtgctg
644401 tcggcggatc cccggacggt gccgccagag cagatcgccg acctggcggt gcgggcgacg
644461 tttctggccg gtcgccaggt ttatcggcgg tgatacccgt gctgcccccc ctagaagccc
644521 tgctggaccg cctgtatgtg gtggccctgc cgatgcgagt gcgtttccgc ggcatcacca
644581 cccgtgaagt ggccttgatc gagggtccgg ccggttgggg cgaattcggt gcgttcgtgg
644641 agtaccagtc cgcgcaggcg tgcgcgtggt tggcgtcggc gatcgagacc gcctactgtg
644701 cgccgccgcc ggtgcgacgt gaccgcgttc cgattaacgc cactgtgccg gccgttgccg
644761 ccgcccaggt gggcgaggtg ctggcccggt ttcctggggc ccggacggcc aaggtgaagg
644821 tcgccgagcc tgggcagagc ttggccgacg acatcgagcg tgtcaacgcg gttcgggagc
644881 tggttcccat ggtgcgggtg gacgccaacg gtggctgggg tgtcgccgag gcggtggccg
644941 cggcggccgc cctgaccgcc gacggcccgc tggaatacct tgaacaaccc tgtgccaccg
645001 tcgccgaact cgccgagttg cgccggcggg tggatgtgcc gatcgccgcc gacgaaagca
645061 tccgcaaggc cgaggatccg ttggccgttg tccgcgctca ggccgccgat atcgcggtgc
645121 tgaaggtcgc cccgctgggc ggtatttcgg cgctgcttga tatcgcggcg cggatcgccg
645181 ttccggtggt ggtctccagc gcgctcgatt ccgccgtcgg aatcgccgcc ggcctgaccg
645241 ccgccgcggc cctgccggag ctcgaccacg cgtgcgggct gggcaccggc gggctgtttg
645301 aagaggacgt ggccgagccc gcagcacccg tcgacggctt tctggcagtt gcgcggacaa
645361 cgcccgaccc ggcgcggttg caagccctgg gtgcaccgcc gcagcggcga cagtggtgga
645421 tcgaccgggt caaggcctgc tactcgttgc ttgtaccgtc tttcgggtga tcaacctggc
645481 ctacgacgac aacgggaccg gtgacccggt ggtctttatc gccggccgcg gcggcgccgg
645541 acgcacctgg cacccacatc aagtcccggc ctttctggcg gctggatatc ggtgcatcac
645601 gttcgacaat cggggcatcg gcgccaccga aaacgccgaa ggcttcacca cgcaaaccat
645661 ggtcgccgac accgcggcgc tgatcgaaac cctagacatc gccccggcgc gcgttgtcgg
645721 ggtgtcgatg ggggcattca tcgcgcagga actcatggtg gtcgcacccg agctggtcag
645781 ctcggcggtg ctgatggcca ctcgcggccg cctggaccgc gcccgccagt tctttaacaa
645841 agccgaggcc gaactctatg actcgggtgt ccagctgcca cccacatacg acgcgagggc
645901 tcgcttactg gagaacttct cccgaaagac gctcaacgat gacgtggccg ttggcgactg
645961 gatcgcgatg ttttccatgt ggccgattaa gtccaccccc ggactgcgct gtcagctaga
646021 ttgcgctccg cagaccaacc ggctgcccgc ctaccgcaac atcgccgcgc cggtgctggt
646081 gattggtttc gccgacgacg tggtgacgcc gccctacctg ggtcgggagg tcgccgacgc
646141 cctgccgaac ggccgttacc tgcagatacc tgacgccggt catctcgggt tcttcgagcg
646201 gccggaagcc gtcaacaccg cgatgctgaa gttcttcgcc agtgtcaagg cctgagcgcg
646261 gcccggccat acggtccggc tgtgacactc tgtactggtg aacccctcga cgacacaggc
646321 gcgcgtcgtc gtcgacgaac tgatccgcgg cggcgttcgc gacgtggtgc tgtgtccggg
646381 ctcgcgcaat gcgccgctgg ccttcgcgct gcaggacgcc gaccggtccg gccggatccg
646441 gttgcacgtt cgcatcgatg aacgcaccgc cggctacctg gccatcgggc tggcaatcgg
646501 ggcgggcgcg ccggtgtgtg tcgcgatgac atccggcacc gccgtggcca acctcggtcc
646561 ggcggtggtg gaggcaaact acgctcgggt gccgctgatc gtgctgtcag ccaatcggcc
646621 ctacgagctg ctgggcaccg gcgccaacca gaccatggaa cagctgggct atttcggcac
646681 ccaggtgcgc gccagcatca gcctggggct ggccgaggac gcacccgagc ggacctcggc
646741 gctcaacgcg acctggcgat cggctacgtg ccgagtgttg gcggccgcca cgggtgctcg
646801 caccgccaac gcgggccccg tgcacttcga catcccgctg cgcgaaccgc tggtgcccga
646861 tcccgagccc ctcggcgcgg tcaccccgcc gggccggcct gctggcaagc cgtggaccta
646921 cacgccgccg gtcaccttcg accagccact ggacatcgac ctgtcggtcg acaccgtggt
646981 catctccggg catggcgctg gcgtgcaccc caacctcgcg gcgttgccga ccgtcgcaga
647041 accgacggcg ccgcggtccg gggacaaccc gttgcacccg ctggcgctgc cgctgctgcg
647101 ccctcaacag gtgatcatgc tgggccggcc gacactgcat cgtccggtat cggtgctgct
647161 ggccgacgca gaagtgccgg tattcgcatt gacaaccggt ccacgctggc cggatgtctc
647221 gggtaactcg caggccaccg gcacgcgggc ggtcaccacc ggcgcgccgc ggcccgcgtg
647281 gctggaccgg tgtgcggcga tgaaccggca cgcgatcgcg gcggttcggg aacagctcgc
647341 ggcgcacccg ttgaccaccg ggctgcatgt cgcggcggcg gtgtcgcatg cgctgcggcc
647401 cggtgaccag ctggtgctcg gggcatccaa tccggtgcgg gatgtggcgt tggccggttt
647461 ggacacccgc ggcatccggg tacggtccaa ccgtggggtc gccggcatcg acggcaccgt
647521 gtccaccgcg atcggggcgg ccctagctta tgagggggct cacgagcgca ccggcagccc
647581 ggactccccg ccccgcacca tcgcactgat cggcgacctg acgttcgtgc acgacagctc
647641 cgggctgttg atcgggccga ccgaaccgat accgcggtca ttgaccatcg tggtgtctaa
647701 tgacaacggc ggcggcatct tcgaattgct cgagcagggt gatcccaggt tctccgacgt
647761 gtcatcgcga atcttcggca ccccacacga cgtcgatgtg ggcgcattgt gccgcgccta
647821 ccacgtggaa tctcgccaga tcgaggtcga cgaactcgga ccgaccctcg atcaacccgg
647881 tgccggcatg cgcgtgctcg aggtcaaggc cgaccggtcg tcgttgcgac aattgcacgc
647941 cgccatcaag gcggctctgt gatatcaccg aaacccctgc tgcacatcct gattcatggg
648001 ctcagtgatg aactgcccga tactcgaggc aggatcgtgc tgcgctggtt acgaatcgcc
648061 gtcctgatag tgaccggttt ggtcacgctg cagtcggtgc ttctggtggc tggtgcgtgg
648121 cgcaatgaca ttgcgatcca acgtaatatg ggggtcgcgc aggctgaggt gctcagcgcc
648181 gggccgcggc gttcgacgat cgagtttgtc acaccggatc ggatcaccta tcggccgcaa
648241 ctcggtgtgc tgtatccgtc cgaattatcc acgggcatgc gaatttacgt tgagtacaac
648301 aagagggatc ccaacctggt cagagtgcag caccgtaacg ccggactggc gatcatcccg
648361 gccgggtcca tcgcggtggt ggcctggctg atcgccgccg ccgcgctggt cgtgctagcg
648421 gtgctggaca agcggttgga acgtcgtgaa aattcggcgt ctgcaacggg ctgagcagca
648481 gagttcgcac gccgtatgcc gctacgcaac catttcgaca gccggcgctg acagtgtgtg
648541 tggcgtgcgc gttgcgatcg tcgccgagtc gttcctcccg caggtgaacg gcgtcagcaa
648601 ctcggtggtc aaggtactcg aacatctgcg tcgaaccggt catgaagccc tggtgatcgc
648661 gcccgacacg ccgccaggtg aagaccgcgc cgagcgactt cacgacggtg tccgggtgca
648721 ccgggtgccg tcgcggatgt tcccaaaggt gaccacgttg ccgctcggcg tgcccacctt
648781 ccgaatgctg agagcgctgc gcggattcga tccggatgtc gtgcatctgg cgtcgccggc
648841 gctgcttggc tacggtggac tccatgccgc tcggcggcta ggggtgccca cggtcgcggt
648901 ctaccaaacc gatgttccgg gtttcgcgtc cagctacggc attccgatga cagcacgggc
648961 ggcgtgggca tggttccgcc acttgcatcg cctggctgac cgcactctgg cgccgtccac
649021 agcgacaatg gaatccctta ttgcccaggg cattccgcga gtacaccggt gggcacgcgg
649081 ggtggacgtg caacgtttcg cgccgtcggc gcgaaacgag gtgttgaggc gacggtggtc
649141 accggacggc aaacccatcg tcggctttgt gggtcggctt gctccggaga agcatgtcga
649201 ccggctcacg ggtctggcgg cctccggcgc cgtgcggctg gtgatcgtcg gcgacggcat
649261 cgaccgggca agattgcaat cagcaatgcc cacagcggtt ttcaccggag cacggtatgg
649321 caaagagctc gccgaggcgt atgccagcat ggacgtcttc gtacattccg gtgagcacga
649381 gacgttctgc caagtcgtgc aggaagcgct ggcgtcgggg ctaccggtga tcgctccgga
649441 cgccggcgga ccgcgtgatc tgataacccc gcaccgcacc gggctgctgt tgccggtcgg
649501 cgagttcgag caccggcttc ctgacgccgt cgcccacctg gtgcacgaac gccagcgcta
649561 cgcgctggcc gcccggcgca gtgtgctggg ccgcagttgg ccggtggtct gcgatgagct
649621 gctcggccac tacgaggcgg tgcgaggtcg gcgcacgacc caggccgcgt aacggtagcg
649681 tcgaggctat gagtcgcgcc gccttggaca aggatccccg cgacgtggcg tcgatgttcg
649741 atggcgtcgc ccgcaagtat gacctgacca ataccgtgtt gtccctgggc caggaccggt
649801 attggcggcg agccactcgg tcggcgctgc ggatcgggcc cggccaaaag gtcctggacc
649861 tggccgcggg caccgccgtg tccaccgtag agctcaccaa atcgggcgcg tggtgtgtgg
649921 ctgccgattt ttcggtcggc atgcttgcgg cgggcgctgc gcgcaaggtt cccaaggtcg
649981 ccggtgacgc cacccggctg ccgtttggtg acgacgtgtt cgatgcggtc accatcagtt
650041 tcgggctgcg taacgtcgca aaccagcaag cggcgctgcg ggaaatggct cgtgtcaccc
650101 ggccgggcgg gcggctacta gtgtgcgaat tctccacgcc caccaatgcg ttgttcgcca
650161 ccgcctacaa ggaatacttg atgcgggcgc tgccccgggt ggcgcgggcg gtgtctagca
650221 accccgaggc ctacgagtac ctcgcggagt cgatcagggc ctggcccgac caggcggtgc
650281 tggcgcacca gatttcgcgg gccgggtggt cgggggtgcg gtggcgcaac ctgaccggcg
650341 gcatcgtagc tctgcatgcc ggatacaaac ccggcaaaca aaccccgcag tgaccggtag
650401 gaagacttag cgggtgccag cccgttgcag gacgcccaca tgctcagggc agtagtgatc
650461 gatcgcggcg cccaggaact gaaacgcttg gccctgggtg gttccgcgcg gcaggttgcg
650521 ttgcaggaaa gtggccgact tgtacgcatc gccgtcaacg cctctgctca gccgttcgca
650581 gctgatcttg gcaagccaag cgttgtagtc ctgcgggccg tagatcccga agcgatggat
650641 cgtgttgttg aagggggcgt cgtagtcgtc ggcctgcgcc ggcgctgcca aactaacggc
650701 agccaccgtc atgccgacga caacagccag ctttgttccc ttcattagcc ggactatacg
650761 cgtcgtttgg gtgcgccgtc agcccaggtg ggccgagagc agccagccac cgatcgactg
650821 cagcccgttg ggctcttcgc ggatgtccag gagtgcgggc atgccggcga agccggccgg
650881 gaacctcgcg tacagccgcg cgggcttgat ctcatcgatg atccagtact tggacaccgc
650941 cgcgcgcagc tcgtcctcgg tgaccgcatt gatcggcccc tcgggtatcg ccgcccggtc
651001 gaataccaac acgaagtagg aggcgcccgg tgccgccgca cgcacgatcg attgcagata
651061 gccctcccgg gactcgaccg gcatggagtg gaacagcgtg ctgtcgacga tggtgtcgaa
651121 cctgccgtca tagccggtaa acgaactggc gtcggccacc tcgaagctgg cattggccag
651181 gccgcgcttc gctgcttcat gccgagccag ttctacggcg gcgggggaga ggtccagtcc
651241 gaccgtggtg tgtccccgtt cggccagtgc cagcgaaatc gcggcctccc cgcagcccac
651301 gtcgaggacg tcgccgcgga acttgccctg cacgatcagg gcggccagct cgggctgggg
651361 ttcgccgatg ctccatggcg gtcggactcc ctccccgaag gcgacggatt caccgcggta
651421 ggcggattcg aactcaagat ccagcgattc agtcatgtgt tcatatatat caacggccct
651481 gatatatgtc aacacagttg acattcgcgc acccttggtt gccggccgtc agctgaacgg
651541 cggtcgtcga tcgacgagcc gggacaattg accgccaccg cgccacaccc gcgccaccca
651601 gtcgcggtcg tcgtcggtga ccagattgga catcacccgc acggcgatgt tcatcaatgc
651661 ggtggagcgc atcgtgatgg gcccagtcgt gggtaggaac cgtgggaagg tcagtaacaa
651721 cgctagccgg cgcgcaaccg agaagccgcg accgtagcgg tcggccagca gcgacggcca
651781 cagccgtgcc aggtcacgcg aatccagcag ttcggcggcc agccgcccgg tttccagccc
651841 gtagtcgatg ccctcgccat tgagcgggtt gacgcaggcc gcggcgtcgc cgatgagcat
651901 ccagttggac ccggccactc cagaaaccgc gccgcccatc ggcaacagcg ccgacgacac
651961 cgcgcgcggc tggccggtga agccccactc gtcacggcgc aggtcggtgt agtaggagat
652021 cagcgggcgc agggccagat cggctggccg tcttgaggtc gacaacgctc ccacgccgat
652081 gttcacttcg ccgttgccca gcggaaagat ccagccgtag ccgggtagca cggcgccgtc
652141 gggggagcgc agttccagat gcgacgtcag ccacgggtca tcgctgtacg ccgtgctcag
652201 gtacccccgg accgcgacgc catagaccgt ctcccgatgc catcgccggc ccagcttgcg
652261 tcccagcggg gatcgggccc cgtcggcaac gatcagctgg cggcagccca cctcagtgcc
652321 gtcggccagg gtcagcgata ccacccgcct cgatgaatca tggtgaacag caacggcttt
652381 agcgccaagt agcatgcgcg caccggtgtc ctcggcgacc tttcggatcc ggtcgtccag
652441 ctcgagacgg gccaccgcgc tgccgtacga cgggaagctc ggaccgggcc agtccacttc
652501 cacctcgcct ccgaagccgc tcatccgcaa cccacgatgc cggatgtggt ccgccagcca
652561 cttacctagt cccagctggt gcagttcggc gaccgcgcgt ggtgtcagcc cgtcgccgca
652621 aggcttgtcg cgggggaagg tggcggtgtc gatgacgagg acgtcgcggc ccgcgcgggc
652681 agcccaggcg gccgcagctg acccggccgg tccggcgccc acgaccacca cgtcggcact
652741 gtcatccacg ctcaccagta tgttggtcga gtgaggactc cggcgacggt ggtggcaggc
652801 gttgacctgg gcgacgctgt ctttgccgcg gccgtgcgtg ctggtgtcgc gcgagtcgag
652861 caactcatgg acaccgagct gcgccaggcc gacgaggtga tgagcgattc gctgctgcac
652921 ttgttcaatg ccggcggcaa gcggttccgt ccactgttca ccgtgctgtc ggcgcagatc
652981 gggccgcagc cggatgccgc agcggtgaca gtcgccgggg cggtgatcga gatgatccac
653041 ctggcgaccc tctaccacga tgacgtgatg gacgaggccc aggtccgccg cggcgcgccc
653101 agcgccaacg cgcaatgggg taacaacgtc gcgatcctgg ctggcgacta cctactggcc
653161 accgcatcgc ggctggtggc gaggttggga ccggaggcgg tgcggatcat cgccgacacc
653221 ttcgcccagt tggtgaccgg gcagatgcgt gagacgcgcg gcacgtcgga gaacgtggac
653281 tccatcgagc agtacctgaa ggtggtccag gagaagaccg gcagtctaat cggggcggcc
653341 ggccggctgg gtgggatgtt ctccggtgcc accgacgaac aggtcgaacg gctgagccgc
653401 ctcggcggcg tggtgggcac cgcgtttcag atcgccgacg acattatcga catcgacagc
653461 gagtctgacg agtcgggcaa gctgcccggt accgatgtgc gcgaaggagt acacaccctg
653521 ccgatgctct acgcgttacg ggaatcaggg cccgattgcg ctcggttgcg cgcactgctg
653581 aacggaccgg tcgacgacga cgccgaggtg cgcgaggcgc tgacattgtt gcgggcgtcg
653641 ccgggcatgg cccgggccaa agacgtcctg gcgcagtacg cggctcaggc acgtcacgag
653701 ctggccttac tgcccgacgt cccgggacgg cgtgccctgg cggcgctggt cgactacacc
653761 gtgagccggc acggctaggt tgcccggcca ggctcgattg cggaaccagc ggatacccct
653821 caggcgttga accagcagta atctcccaag ttgaggtgtt ctaggaggac acgcactgat
653881 gacttggcat ccgcatgcca accggctgaa gacgttcctg ctgttggtcg gtatgtccgc
653941 gttgatcgtg gccgtcggcg cgttgtttgg caggacggcg ctgatgctgg cggcgctgtt
654001 cgccgtcgga atgaacgtct acgtctactt caatagcgac aagctggcgc tgcgggcgat
654061 gcatgcgcaa ccggtttccg aactgcaggc gccggcgatg taccggatcg ttcgagagct
654121 ggcgaccagc gctcaccagc cgatgccccg gctgtacatc agcgacaccg ccgcacccaa
654181 cgcgttcgcc accggccgca acccgcgcaa tgccgcggtg tgttgcacga ctggcatcct
654241 gcgtatcctc aatgagcgtg agctgcgtgc cgtgctgggc cacgagctgt ctcacgtcta
654301 caaccgcgac atcctgatct cttgtgtggc aggtgcgctg gcagcggtga ttaccgcgct
654361 ggccaacatg gccatgtggg ccggcatgtt cggcggcaac cgagacaacg ccaatccctt
654421 tgcactgctt ctggttgcgc tgctgggccc gatcgcggca accgtgatac ggatggccgt
654481 gtcgcgatcg cgggagtacc aggccgacga gtcgggtgcc gtcctgaccg gggacccgct
654541 ggcgttggcg tcggcattgc gcaagatctc cggcggcgtc caggcggcgc cgctgccgcc
654601 ggagccgcag ctggccagcc aggcgcacct gatgatcgcc aacccgttcc gggcgggtga
654661 gcggatcgga tcgctgtttt cgactcaccc accgatcgag gaccgcattc gccggctgga
654721 ggcgatggcg cgcggctgat aactgtgggt atcgagatgc catcggtgat gagtcaggcg
654781 ccgctatcga ggaggcggtc gatcagttcg tggctggcat gccggcgtgc ggcgaggacg
654841 cgcccgtccc actgaccgaa cgcaacagcc gaactatcgt tgtgcggaca tcaccggcat
654901 gcgtgccggc agcggtggca agcctaaaac cccgagccgt gcacctcgtg tccggggacc
654961 tcggcgatca agcctctata cgcctgctcc accgtcgaac catggttgat gacggcgtcg
655021 acctcgcggg cgatcggcat gttcagcccg aactcgttgg cgaactccat caccacaccg
655081 gcagctttga cgccctcggc gacctggctc atcgatgcga tgatttcgtc gatcggcttg
655141 cctgcgccga gttgttcgcc cacatgccgg ttgcggctgc gttggctggt gcaggtgacg
655201 atcaggtcgc cgagaccggc cagtccgggg aacgtttcgc ttttcccacc cattgccaca
655261 cccagcttcg tcatctcgcg cagcgcgcgg gcgatcacca gggcgcgggt gttttcgccg
655321 atacccagcg aatagcccat cccgaccgcg atggcgaaga cgttcttgag ggcgcccgcc
655381 gtctcgacac cgacgacgtc gtcagttgtg tacacgcgga agcgccgggt gcgaaacatt
655441 gctgatagcc gggtcgccag gtgctggtcg ggcatggcca gcaccgccgc ggccgcgtag
655501 ccctcggcca cctcgcgggc gatgttcggg ccggccagga tgcctgccgg atgaccgggc
655561 agtacctcct cgatgatctg cgacatccgc atattggtgc cctgttcgag ccccttgacc
655621 agggacacca ctggcaccca gggtcgcagc tctttgctca gctcgacaag cactccgcgg
655681 aaaccgtgcg agggcacccc catgacgacg acgtcggcgc agttggcggc ctcggtgaag
655741 tctgtggtgg cgcgcagggt gtcgctgagc accacgtcgt tgccgaggta tcggctattg
655801 cggtggttgt cgttgatgtc ctgcgcggtg accgccgagc gcacccactg caaggttggt
655861 ccgcggcgcg cacagatgga ggcgacggtg gtgccccagg aaccgccgcc gaggacaacg
655921 actttgggtt cgcgcttgtt ggctgccatg gcgttcagcg tattgcggca accggacatt
655981 tgatatccgt cgacgaaccg caggagcaat catgccgcgc cgaacaccat tgcctcctcg
656041 atgcggtcga atcggtagtc gatggcgtcg gccaagtagt tctgtcgtac attccacggc
656101 cgcttggtgc cggacttggg cagcgcgtac ggcgcccgct tcacatagcc ggcctgaatg
656161 tcccaggacg gtttctcgtc catcggctcg tcgcccaggt gcggggcggc gcgcgtgtgt
656221 ccatgggcgg ccatgtgtgc cagtagtttt gccgtcgccc gggccgtcat gtcggcgcgc
656281 agcgtccagg acgcgttcgt gtaacccaca caccagaaca ggttgggcac gtcttcgagc
656341 atgtgcgcct tgtagacaaa gcgatcccga gggtcgatct cgacgccgtc gaggctgatc
656401 gcggccccgc caagcgcttg caactgcagg ccggtggcgg tgacgataat gtccgcatcg
656461 aggtgcccac cggatttgag tgcaataccg gtggcgtcga agtggtcgat atggtcggtg
656521 accacctcgg cgcggccgct ggtgatggcg ttgtacaggt cggcgtccgg gatcaggcac
656581 agtcgctgat cccacgggtt gtaccgcggc gtgaagtggg tttcgatgtc gtagccctcg
656641 ggcagatttt tgatcgcggt acggcgcagc agccatttca cgaacaccgg tgtcttgcgg
656701 gacaagaacc agaacaccgc ttccaataac gcgttgtaca ttcggacaat caagtgagaa
656761 gttttgggag gcaacgcttt acgaacaacg gcggcgaacg tgctgtattt ggatgccgag
656821 atcaggtagg tcggggatcg ctgcagcatg gttacctttt cggcccggtc ggtcagcgag
656881 gggatcagtg tgaccgcggt ggccccgctg ccgatcacca cgatcttctt gccggtgtag
656941 tccagatcct ctggccagtg ctggggatgc actaccgcgc cgccaaactt ctcgatgcct
657001 ccgaagtcgg gggtgtagcc ctcgtcatag ttgtagtagc cgctgccgaa gaacacgaac
657061 cggctgcggt agtgcttgtg cacgccgttc tgctcgaagg tgacggtcca ggtatcggtg
657121 gatgagtccc agtccgctgc gcgaacgtag ctgttgaact cgatgtggcg atcgatgccg
657181 tacttgtggg ccatgtcggt gaggtactcg cggatgtggg cgccgtcggc gatgccttct
657241 tcgcgggtcc acggctcgta gggaaacgac agcgtgaaga tgctgctgtc ggagcgcacg
657301 ccggggtagc ggaacagatc ccaggtgccg ccgatccgcg cacgcctttc caggatggtg
657361 taggtcagct gcgggttgcg ttcgatgatc cggtaggccg cgcccagtcc ggagatgccg
657421 gcgccgacga tgacgacgtc gacacagccg gcgtttggag tcacgctcat cgtgaacctc
657481 gcttgaaatc ctggatcagc gaccagggta gccaggacat ccagccagcc cctccagatc
657541 gccgcgacta gcggtagttc acaaactgca atgccacatc caggtcggcc ttcttcagca
657601 tggcgatgac ggcctgcagg tcgtcgcgct tcttgctggt gacccggacc tcgtcgccct
657661 ggatctgggt tttgacgttc ttggggcctg cgtcgcggat gagcttggtg atcttcttgg
657721 cgttctcgct gctaatgccc tgtttgaggg cgccggtaac tttgtacgtc ttacccgagg
657781 cctgcggttc tccggcctcg aaggccttca gcgagatgtc gcggcggatc agcttctcct
657841 tgaagacgtc gacggcggcc ttgacacgct cctcggtgga cgaggtgagc tcgacggcct
657901 cgtcgccctt ccacgcgatc ttggtgtcgg tgccgcggaa gtcgaagcgc gtggccagct
657961 ccttggcggc ctggttgagt gcgttgtcga cctcctgccg gtcgaccttg ctgacgatgt
658021 cgaacgatga gtccgccatt cggttcgtcc ctccttcgcg agatagccgt gtgtgctctg
658081 tctacccggt cgttgtaccc tgctaggcgg caggttgccc gagcggccaa tgggagcgga
658141 ctgtaaatcc gtcgcgaaag ctacgcaggt tcgaatcctg cacctgccac cacggtcaag
658201 ctggtatccg ggcatgggcg ccgggcatgg ccacgcccgc gcgttggtgc cccaacgtcg
658261 cctacggtcg gtagacagcg gcgcgacacc cgcactccaa caatttcggg aggtcaagtg
658321 gtggagttga gcccggatcg gatcatggcg atcggcggcg ggtacggccc gtctaaggta
658381 ctgcttaccg cggtcgggct tgggctgttc accgaacttg gcgatgaggc catgaccgcc
658441 gaggccattg ccgaccgcct cgggttgcta aagcgaccgg cgattgactt cctcgacgcc
658501 ttggtctcgc tggacttgct ggcgcgagac ggcgacggac ccgggtccca ctaccgcaat
658561 acaccggaga cagcgcactt tctggacgag gcccgtccca cctacgcggg cggcctgctg
658621 aagatctgga acgaacgcaa ctaccgcttc tgggcggatt tgaccgaggc gctcaagacc
658681 gggaaggcac aaagcgaggt caagcaaacc gggcggccct tcttcgaggc gctctatgca
658741 gatcctcggc ggctcgaggc gttcatggcg gctatggacg cggcgtcgcg acgcaacatc
658801 gagctcctcg cgaaacgctt tccgttcgag cgctaccggc gtctctgtga cgtgggctgc
658861 gcggacggtc tgttgtcacg aatcgtcgcg gcggctcacc cgcacttgca gtgcgtcagc
658921 ttcgacttgc ccgcggtgac cgagatcgct cgacgcaagc tgacagccga gggtttgggt
658981 gagcgggtgc aggcgtgcgc cggtgacttt ttggccgacc ctctgccggc ggccgatgtc
659041 atcacgatgg gccagattct gcacgactgg aacctcgacc gtaaacagca gttggtcgct
659101 aaggcctacg aggccctgtc caaggagggg gctttcattg tgatcgagac attgatcgac
659161 gacgcgcgac gcgaaaacac aaccggcctg atgatgtcac tgaacatgct tatcgagttc
659221 ggtgacgcgt tcgactactc cgccgccgac ttccgggggt ggtgtggcga ggcgggattc
659281 cgttcgttcg aggtgatccc gcttgccggc ggctccagcg cggcggtggc ctataaatag
659341 tgggcaatga catggtgggt ggccgaccaa cgtgaactga ggacggcaaa tcggcctcag
659401 ttcacgctcg gcgctttgag caacaaattg aacacataga atcgtgtcga tgagcggcac
659461 atcgtcgatg ggattgccgc cgggacctcg actttccggc tcggtgcagg ccgtgttgat
659521 gttgcgccat gggctgcgtt ttttgacggc ctgtcaacgc cgttacggca gtgttttcac
659581 gctgcatgtc gcggggttcg gccacatggt gtatctgtcc gatccggccg ccatcaagac
659641 agtgtttgcc ggcaacccga gtgtctttca cgccggcgaa gccaactcga tgttggccgg
659701 actgctcggc gacagctcac tgctgttgat cgacgacgac gtgcaccgcg accggcgtcg
659761 cctgatgtcg ccgccgttcc atcgcgacgc ggtcgcgcgc caggccgggc cgatagccga
659821 gattgccgcc gccaacatcg ccgggtggcc gatggctaag gcgttcgcgg tggcgcccaa
659881 gatgtctgag atcacccttg aggtgatcct gcggaccgtc ataggcgcca gcgatccggt
659941 ccggctcgcc gcgctgcgca aggtcatgcc gcggctgctc aacgtgggcc cgtgggcgac
660001 gctcgcactg gccaacccga gcctgctgaa caatcggctc tggagcaggc tgcgacggcg
660061 gatcgaagaa gccgacgccc tgctgtacgc cgagatcgcc gaccgccgag ccgatcccga
660121 tctggccgca cgcaccgaca cgctggccat gctggttcgg gccgccgacg aagacggacg
660181 gacgatgacc gagcgcgagc tgcgcgacca gctgataacg ttgctggtcg caggtcacga
660241 caccaccgcg acgggactgt cgtgggcact ggagcggttg acccgccacc cggtcaccct
660301 ggccaaggcc gtgcaagcgg ccgacgccag cgcggccggc gatccagccg gcgacgagta
660361 cctggacgcg gtggccaaag agacactgcg gatccgcccg gtggtgtacg acgtgggccg
660421 ggtcctcacc gaggcggtgg aggtggccgg ttaccggctg ccggccgggg tcatggtggt
660481 cccagcgatc gggctggtgc acgcgagcgc gcaactgtat ccggatccgg aacggttcga
660541 ccctgatcgg atggttggcg ccactttgag cccgaccacc tggttgccgt tcggcggcgg
660601 caaccgccgc tgcctcggcg ccacctttgc catggtcgag atgcgggtcg tccttcggga
660661 gatcctgcgc cgcgtcgagt tgagcaccac cacgacctcc ggcgaacggc cgaagctaaa
660721 gcacgtcatc atggtgccgc accgcggcgc gcgcatccgc gtccgggcaa ccagggacgt
660781 ttcggccacg tcgcaagcga cagcccaggg tgccggatgc ccagccgctc gcggtggcgg
660841 gccgtccaga gccgtcggca gccagtgacc agctggggta tccgcatggg gtcgcccagc
660901 gggtcccgag gggacttttg gccaccggcg ctggtggcct actgccctcc cgccgttgcg
660961 ccgggtgcgt gcacgattga agtccccaag gaagggacgc tcatgaaggc aaaggtcggg
661021 gactggctgg tgatcaaagg cgcgacgata gatcaaccgg accaccgagg gttgattatt
661081 gaggtgcgct catccgatgg ttcgccgccg tatgtggtgc gctggctcga gaccgaccat
661141 gtggcgacgg tgattccggg tccggatgcg gtcgtggtca ctgcggagga gcagaatgcg
661201 gccgacgagc gggcgcagca tcggttcggc gcggttcagt cggcgatcct ccatgccagg
661261 ggaacgtagg cgattcgctc aagcgacgaa gtcggtgggt gtcagctggc cggcgaaagt
661321 ccggcgccgg gatggaacgc tggtgccgtt cgacatcgcg cggatcgaag cagcggtgac
661381 gcgggcagcg cgcgaggtgg cttgcgacga ccccgatatg ccgggcaccg tagcgaaagc
661441 cgtcgccgac gcactcgggc gcggtatcgc tcccgttgag gacattcagg actgcgtgga
661501 ggcccggctg ggggaagccg gtctggatga cgtggcccgt gtttacatca tctaccggca
661561 gcggcgcgcc gagctgcgga cggctaaggc cttgctcggc gtgcgggacg agttaaagct
661621 gagcttggcg gccgtgacgg tactgcgcga gcgctatctg ctgcacgacg agcagggccg
661681 gccggccgag tcgaccggcg agctgatgga ccgatcggcg cgctgtgtcg cggcggccga
661741 ggaccagtat gagccgggct cgtcgaggcg gtgggccgag cggttcgcca cgctattacg
661801 caacctggaa ttcctgccga attcgcccac gttgatgaac tctggcaccg acctgggact
661861 gctcgccggc tgttttgttc tgccgattga ggattcgctg caatcgatct ttgcgacgct
661921 gggacaggcc gccgagctgc agcgggctgg aggcggcacc ggatatgcgt tcagccacct
661981 gcgacccgcc ggggatcggg tggcctccac gggcggcacg gccagcggac cggtgtcgtt
662041 tctacggctg tatgacagtg ccgcgggtgt ggtctccatg ggcggtcgcc ggcgtggcgc
662101 ctgtatggct gtgcttgatg tgtcgcaccc ggatatctgt gatttcgtca ccgccaaggc
662161 cgaatccccc agcgagctcc cgcatttcaa cctatcggtt ggtgtgaccg acgcgttcct
662221 gcgggccgtc gaacgcaacg gcctacaccg gctggtcaat ccgcgaaccg gcaagatcgt
662281 cgcgcggatg cccgccgccg agctgttcga cgccatctgc aaagccgcgc acgccggtgg
662341 cgatcccggg ctggtgtttc tcgacacgat caatagggca aacccggtgc cggggagagg
662401 ccgcatcgag gcgaccaacc cgtgcgggga ggtcccactg ctgccttacg agtcatgtaa
662461 tctcggctcg atcaacctcg cccggatgct cgccgacggt cgcgtcgact gggaccggct
662521 cgaggaggtc gccggtgtgg cggtgcggtt ccttgatgac gtcatcgatg tcagccgcta
662581 ccccttcccc gaactgggtg aggcggcccg cgccacccgc aagatcgggc tgggagtcat
662641 gggtttggcg gaactgcttg ccgcactggg tattccgtac gacagtgaag aagccgtgcg
662701 gttagccacc cggctcatgc gtcgcataca gcaggcggcg cacacggcat cgcggaggct
662761 ggccgaagag cggggcgcat tcccggcgtt caccgatagc cggttcgcgc ggtcgggccc
662821 gaggcgcaac gcacaggtca cctccgtcgc tccgacgggc accatctcac tgatcgccgg
662881 aaccaccgcg ggcatcgagc cgatgttcgc tatcgcgttc acccgcgcca tcgtcggccg
662941 gcatctgctg gaggtcaatc cgtgcttcga ccgactggcc cgcgatcggg gcttttatcg
663001 tgacgagctg atcgccgaga tcgctcagcg tggcggagtc cgtggctatc cgcggctgcc
663061 tgctgaggtg cgggccgcgt tcccgaccgc ggcggagatc gcgccgcagt ggcatctgcg
663121 catgcaggcc gcggtgcagc gccacgtcga ggccgccgtg tccaagacgg tcaacttgcc
663181 cgccacggcg acggtcgatg acgtccgcgc catctatgtg gccgcctgga aggcaaaggt
663241 caagggcatc acggtgtatc gctacggcag ccgggaagga caggtactgt cctacgccgc
663301 gccgaaaccg ctactggcgc aggctgacac ggagttcagc ggcggctgtg cgggccgctc
663361 ctgcgagttc tgacggcggc tcccatggcg cgagcagacg cagaatcgca caaaatcagc
663421 gattttgatg cgattctgcg tctgctcgcg cagggatcgc agggatcacc ccggccggct
663481 agcggtttag ccgcttgggc ctgggccgca caagtggtcg atgaaccaat cgcacgccag
663541 cttggcaacc tgttccagcg tgcctggttc ttcgaatagg tgtgtggcgc cggggaccac
663601 ggtgagttgg catttcccgg gtattaccgc ttgcgctcgt tggttcagct cgaggaccac
663661 ctggtcgcgt ccacccacga tcagcagcgt cggtgccacc acgctcccca gcgaatcacc
663721 cgcgagatcg ggccggccgc cgcgggacac caccgcccgc acgttcacgc gcggatcggc
663781 ggccgcgacc agcgccgcac ccgctcccgt gctggcgccg aagtagccga ccggcagcga
663841 tgcggtgtcg ggctgggtgg ccaaccaacc ggtcacgtcg atgagtcggg aagcgagcag
663901 ctcaatgtcg aagacgttgg cgcggttgcg ttcttcttcg ggcgtgagca agtcgaataa
663961 cagcgtcgca aacccggccc cggtcaagac ctctgcaacg taccgattgc ggatactgtg
664021 ccggctgctg ccactgccat gtgcgaaaac cacaattccc ctgggttttt cggggacagt
664081 caggtgccct gccaccggta ctggaccggc aacgacctgg acctcctcat cgcgaagcgg
664141 tgggtcagcg gcggcatcga tcgcacctgc ctcggcgaag tcgcggtgag cacgatccag
664201 aaacgccacc acctcgtcgt cggaggtctg ggtgaagttg cggtaaccct gcccgacggc
664261 gaagaacaac gccggcgtcg ccaaacacac cacctcatcg gcgtacccgg cgaatctcgc
664321 cacgatgtcg tctgggccga tcgggaccgc cagcaccacc ttgtccgcac cgtgcgcccg
664381 ggcgacctgg cacgccgcct tggccgtcgc tccggtggcg atgccgtcat cgacgatcac
664441 cgcgatccgc ccggtcaacg ggatgcggtc acgcccgcgg cggaagcgtt ccgcgcggcg
664501 ttgtagctcg atcagctgct tgcgttcgac cgcgtccatg gcggcagcat cgaggtgtgt
664561 cccgcggacg acgtcgtcgt tgagcacccg cacgccgtcc tcaccgatgg cgccgaaagc
664621 caattcgggt tggaacggca cgccaagctt gcgcacgacc aggacgtcga gtggcgcttg
664681 cagtgacttg gcgacctcaa aggccaccgg taccccgccg cgcggcaagc caaggacgac
664741 gacggccttg ccggatagct gcgccaggcg ttgcgccaac tggcgtccag cgtcgccacg
664801 atcgtcaaag agcttcatct gccgagtgtg tcgccatctc atggctccaa atatggaatt
664861 aggtccctgg gccgactgac gacagtccct cagcgaccgg attgcgcatc ccgccttgta
664921 cgctactccg caaatcccgg gcttgcgtcc gcggaagcga actcggcggc gctacggtgg
664981 tggctcactt cggccgtgcg cactcggatc gacgggccga tggcggccgg gcccgcgcgc
665041 ttcataggtc atcggattga ggtgatcgac tcggcgatga gtgttcgaaa gatgactcag
665101 tggtgtgcct tccgtcggtg agctgcacga catatgtgcg gtcgtcggcg tcgtactcaa
665161 ccgtgccgcc cgagacaacc atcccaacca acgcattgcc gtcctggaag tagtacgcgt
665221 tcttttctcg gcgcatggaa tccaggtggc aaccgggcac tatgaggacg ctcctgcggg
665281 gatcgtcggt gaagaccaga atccgcgcgc cccgtttctg ggctagggga tgcttcgtag
665341 gcttccgttg ccgcatgtgc cgcttgatgg cgtgctcacc cattttggtt ttgccctctc
665401 acttgacgct gcgttgccta gcatgccaac cggctagctt cgcggaacgt gctccccggg
665461 gtgcgggcat tcaccgggca cgtgaatcag tactgcgccg tcatcgacga tcccggcttg
665521 accgcggcga tgggcggtga tgtatagcca tccgggttcg atggtttgct tgcagcgtgt
665581 acattgcggg tcggcggcca tgtgctcctc gcttccctag cctcacggtt tgcgccgtcg
665641 gtcgacaggc gaactgctct tcgccgatgt acgtcactgc ttcggcggct aaaccccttg
665701 tccagcacga caagtccaac cggcctgcgt cggcggagtt tggcctcgtg ctcggctggc
665761 ggtgctcatg gtgtccctcc ggaactcggg gtaacggcaa gctttcgatg cgtcggcagt
665821 ccgaaatcta gagacgacga acttgttgtt ctagggtcgt ttggccttcg ccccgacgac
665881 gttggacccg gggtgggctt cggccgtgtc ggcgtgccgc agccgggcga gttcgcccac
665941 gatcctgtcg ctgaccgcca ccggatacga gtagccggtg tcctcgagcg agcgcagctc
666001 cggcgggagc gcgtcgatct gctggcgggc ccagtcccgc gcgccgtcca atgtgggtgc
666061 atgctgccgg atgcgtcggc cgttggtcat gatgggcacc agcaacgggt ccccgggaag
666121 gttttcaccg tgctcgccga gcgtgtcgcc gcaaaagact ccgtgctcga gcttacggaa
666181 cacctgcttg cgtcccgggt agatcacctt gccgctggag aacttggtgc gcccgctgcc
666241 gtcgtatgcc accagcttgt aggccatgtc cagcgcgggc gcgtcttgag ccacgacgag
666301 ctgggtgccc acgccgaagc cgtcgatcgg acagcgggca gccaaaagcg cggcgatgcg
666361 gttttcgtcg aggcccgacg acgcgaagat ctcgacctgc tcgagaccgg cggtgtcgag
666421 ccgtgcacgg gtcgccttgg acagctcatc gaggtcgccg gaatccagcc ggaccgcgcg
666481 cacatcgaag cgattgccca gccgcttggc caactcgatg acgtgatcga cgccgcgtag
666541 cgtgtcgtag gtgtccacga gcagcatggt ggctgggtag agccgggcga acgcctcgaa
666601 cgcggccacc tcactgtcga aggcttgaac aaagctgtgc gccatggtgc cgaacgtcgg
666661 gatcccatat tggcgggccg cgagcagatt cgacgtgccc gcagcgcccg cgagataact
666721 ggtgcgcgcg accttgcagg ccgcgtcggt gccgtgagcg cgccgcgcgc cgaaatccac
666781 caccggtcgt ccgcgcgcgg cggcgaccac ccgcgcggcc ttgctcgcga gcacgctttg
666841 cagatgaatc tggttcagca caaacgtctc gacaagctgg gcctcgatga ttggcgcgat
666901 cagctggacc gcgggttcgt tcggaaaaat cacggttcct tccggcgcgg cccagacatc
666961 tccggtgaaa cgcactccgg ccagccacct caggaactcg tcggaaaact ggcccaggcc
667021 acgcaggtaa cgcagatcct gctcgtcgaa tcgaaacgct tcgaggaact cgaccacatc
667081 ggccagcccg gcggccatga tgtaggacct gccaggcgga agcttgcgga agaatatctc
667141 gaaaaccgct gtgcccgaca ttctttcggc ccagtaggcc tgggccatcg tcacctcgta
667201 caggtcggtg aacagcgcgc cgacgtgttg gcggatcgcc atggttgccg gttactcctt
667261 gctcgttagg ttggcagcgg gaacgacctc cagcaggttg tcgggtcgag tcacgactcg
667321 aatcccgaac cggcggctga tgcgctcaat ggtgttgcgg agccattcgg tgtcggtctg
667381 ggaggcacgc tgtaggcgca tccgcgacac tcgcagtgga agcatctgca gcgagatcag
667441 gttcccgctg gcgggatcgg tgacggtcag atacagcagt cgcagttcac tgcggaacga
667501 ctcgtgcccg ccgatgcctt cgtagtcgtc aacgacgtca ccgcatccgt acaggatcgg
667561 tttaccgcga tatatctcga ttggccgcgg atggtgcgag gaatgtccgt ggaccatgtc
667621 gatgccggcg tcgatcagtc ggtgcgcgaa cgcgacgtcg ccgggtgcgg tcgcatagcc
667681 ccaattggat ccccaatgca tcgagactat ggcgatatcg ccggggcgtt tgtccgccag
667741 cacctgtgcc gccacatcgt cggcgacgtc gcgttgcgcc ggatcccgga tcaaccacac
667801 tccgggccgg tcgcggcggg cggcccagga ttcggggacg ccgctggatt ccgccgctac
667861 cgagccgacg atcacccggc gttcatggcc aaccgtgact agcgccgagc ggcgagcggc
667921 gagcaaatcg gctcccgccc cgacactctg gatccccgca ccggcgagag ccgcgaccgt
667981 atcggtcagc ccctggtagc cgaaatcgag aatgtggttg ttggccagcg cgcacacgtg
668041 cggccgcaat gccgtcagcg ccggcacgtt atccgggtgc atccggtagc agaccggttt
668101 gcggtcggcg aattcaccgt cggcggtgat cgtcgtctcc agattgatca aacagacgtc
668161 ggtcgcggtg ttctcaagga ccgccaacgc ctcgccccag ggccagcgcc aatccacggg
668221 gagcggaatg cgcccgttca cccgctcggc caggcgaaca tagccggtcg catcccgcat
668281 ataccgttcg cgcaattgcg gtttgccggg atgaggcagg atctgatcga cgccacggcc
668341 gagcatgacg tcaccgccca gcagcaccgt caccacatca ggattgccag ccactccgga
668401 ccaccgccgc cttcaggtaa tcgccgtaac acgcacccta tggcgtacat tgcacgtcat
668461 acgatcggcc ggcggcggcc tcgtgggtgg ggccgaaggt cctcaagacc gcgcccaaag
668521 gtcacattgc cggcgacaaa ccgtgcctac ctggcggaga ggtgcccgtc ggcggtggtc
668581 accaggtgta gtcgggcagc tcgaagtcgt cacgcacgct gccggcgaac agcgtcgcca
668641 gcgggccgaa gttcatcgtg cgcatcgcaa cgttgcgaaa ccacaggccg aatcgggttc
668701 gggtggcgaa aaaccagatg aacttcgccg cactggcttg cttgccctcg atgaagggac
668761 gcaggcgctt ctcgtaggcg tcgaaggcgc gacggtggtc gcccccggcg cgggcgagct
668821 ccccggccag cacgtaggcc tcggtgatcg ccaggccggt gccctcgccg ccgagcagcg
668881 agatgcaccc ggccgcgtcg ccgatcagca gcacccgacc gcgtgaccag cggtccatcc
668941 ggatttggct gaccacgtcg aagtacaggt cctcgacgtc gtcgagggcg gccagaatgt
669001 cccggctttc ccagcccacg tcgccgaatt ggtcgcgcag ctcatctttg ggtgccacgc
669061 cggggttgtc gtgttcggcg cggaagacga acaagaacat ggtgcggtcg ccgcgcagcg
669121 cgaaccgcgc cagctgtcgg tcgacggtgt tgtagaggac atagctgcgc tcgtcgcggg
669181 gccggtagcc gtcgaccacg caggccgcga ccttgcagcc caggtagtgc tcgaaatccc
669241 gctccggccc gaagaccagc cggcgcacgt tggagtgcag tccgtcggca ccgatgacca
669301 ggtcgaaatc gcgcggggcg gtcctttcga aggtgagccg gacgccgtcg cggtgctcgt
669361 cgatggtggc gatgctgtcg tcgaagatcg tttccacttg gtcttcgatc gtcgtgtaga
669421 tcgcggcggc gagatcgccg cgcggcaagc tggtgaagtc gtcgccgacc atgcggcgaa
669481 agacgtcgac gcccaggtcg gctttgacct tgccggtggg accgacggag cggacgtgtt
669541 ccatgtggta acccgccgct gcgatctggt ccgtgatgcc cattcgtttg gccacctggt
669601 agccgacgcc ccagaagtcg atcatgtagc cgccggtgcg gaacttcggc gcccgctcga
669661 tcactgtcgg ggtgtggccg gtgcgctgca gccagtgggc gagcgccgct cctgccacgc
669721 cggcaccgct aatcgctact ttcacactgc aattgtgctc ttcggcaata gtttagaaca
669781 agaccggtcg ctcgttgccc cttgatcaat acgttagtga gcgctaacgt attggcgtgt
669841 gcccgacatg ctggaagtcg cggcagagcc aacccggcgc cggctgctac agctcctggc
669901 accgggtgaa cgcaccgtta cccagcttgc gtcgcagttc acggtcaccc gttcggcgat
669961 atcgcagcac ctcggcatgc tcgccgaagc gggattggtt accgcccgca aacagggccg
670021 ggaacggtac taccggctcg atgagcgcgg ggtgctgcgg cttcgtgcgc tcatggagtc
670081 cttctggagc gacgagctgg accgtcttgt cgccgatgcc gcccactacc cgccgtcaca
670141 aggagactgt gccatgccgt tcgagaaagc ggtcgtcgtg cccttggatc cgaccagcac
670201 cttcgcgctc atcacccagc ccgacaggct tcggcgctgg atggccgtcg ccgcgcgtat
670261 cgagctgcgc accggtggcg cttatcgctg gacggtgact ccggggcata gcgcggccgg
670321 caccgtcatc gacgtcgacc ccggcaagcg ggtggtcttc acctggggtt gggaggacca
670381 cggcgacccc ccgccgggcg ggtcgacggt gaccatcacg ctgaccccgg tcgacggcgg
670441 caccgaggtc cggctggtcc acgacgggct gaccgcgcag caggccgccc ggcacgccaa
670501 agggtggaac cacttcctgg accggctggt cgtcgccggc caacgcggtg acgccggtcc
670561 cgacgaatgg gccgcagcgc ccgatccgct cgacgaatta tcttgtgccg aagcaacatt
670621 ggccgttctt cagcacgtac tgcgcgggat aggcgcctct gacctgacca ggcagacacc
670681 gtgtacggaa tatgacgttt cgcaactggc ggatcatttg ctgcgctcgc tggcgatcat
670741 cggcgctgcg gcgggcgcgc agctggcgcc ccgcgatgtg gacgcgccac tggaaaccca
670801 ggtggccgac gcggcgcagg ccgtgatgga agcctggcgg cggcgtggct tggcgggcac
670861 ggtggagctg aactcgaacc aggtgcctgc gacggtgccg gtcggcatcc tgtgcctaga
670921 atttctggtc cacgcttggg atttcgcgat tgccaccggt tctcaggtga tcgcgtccga
670981 gccggtgtcg gagtacgtac tggcggtggc cggcaaggtc atcaccccgg caacccgtaa
671041 ctccgcgggc ttcgccgcgc cggcggcggt cggttccttt gccccagtcc tcgatcgcct
671101 catcgccttc accggccgcc agccgaccgc aggccacgtg tccgccacct aacgaaagga
671161 tgatcatgcc caagagaagc gaatacaggc aaggcacgcc gaactgggtc gaccttcaga
671221 ccaccgatca gtccgccgcc aaaaagttct acacatcgtt gttcggctgg ggttacgacg
671281 acaacccggt ccccggaggc ggtggggtct attccatggc cacgctgaac ggcgaagccg
671341 tggccgccat cgcaccgatg cccccgggtg caccggaggg gatgccgccg atctggaaca
671401 cctatatcgc ggtggacgac gtcgatgcgg tggtggacaa ggtggtgccc gggggcgggc
671461 aggtgatgat gccggccttc gacatcggcg atgccggccg gatgtcgttc atcaccgatc
671521 cgaccggcgc tgccgtgggc ctatggcagg ccaatcggca catcggagcg acgttggtca
671581 acgagacggg cacgctcatc tggaacgaac tgctcacgga caagccggat ttggcgctag
671641 cgttctacga ggctgtggtt ggcctcaccc actcgagcat ggagatagct gcgggccaga
671701 actatcgggt gctcaaggcc ggcgacgcgg aagtcggcgg ctgtatggaa ccgccgatgc
671761 ccggcgtgcc gaatcattgg cacgtctact ttgcggtgga tgacgccgac gccacggcgg
671821 ccaaagccgc cgcagcgggc ggccaggtca ttgcggaacc ggctgacatt ccgtcggtgg
671881 gccggttcgc cgtgttgtcc gatccgcagg gcgcgatctt cagtgtgttg aagcccgcac
671941 cgcagcaata gggagcatcc cgggcaggcc cgccggccgg cagattcgga gaatgctaga
672001 agctgccgcc ggcgccgccg cccccgcctg cgcccccggc cccgccgcgg ccgtcggcgc
672061 cggggctgcc gaactggccg ggctggccgg attggccgat gatggccagg ggcccgaggt
672121 gtgcggtgcc gccggtgcca ccggtgccac ccttaccgcc agccccaggg atcgggaata
672181 aaccgccggg gtcggcccct ttgccgccgt ccccacctcg cccgcccgcc ccagcggtcc
672241 tgaagccgtc gccaccgtgc ccgccgtccc cgccattccc accggaactg gcatcaaggc
672301 cgtcgccgcc gaagccgccc cttccgccgt caccgccggc gctgacggtg ctggtgccgc
672361 cggcgccgcc catgccgccg gtgccgccgg ggccaaaggc ggagccaagg ccgccactgc
672421 cgccgacgcc accgtttccg gcgcggccgg ccgcccctgt cgcaccggtc gcgcccaggg
672481 tggaaccggt cccgccggca ccgccggcac caccggtgcc gccggtgccg ccggtgccgc
672541 catttccgcc agtcccgcca gtgccagcga ggctgctgaa gagagtgccg tgggcacctc
672601 tgccgccgtc gccgccggtg ccgccggtgc cgccggcgcc accggcccca ccatctccgc
672661 cggcgccttg gctgccgttg ttgcccgttg gcgacagcgc tttgccgccg gccccgccgt
672721 tgccgccgcc gccgccggcg ccgccggtcc cgccaacccc gccggtgcca ccgttaccgc
672781 cgtgaccgtc cgcgccagcg tcgaatgtgc cggtcgcacc ggtggcgccg gtggtgcccc
672841 gcaggcccgt cccgcccgtg ccgccggccc cgccccggcc gccgtcagcg ccgtcgccgg
672901 cgacgctccc accttgcccg cctacgccgc cgtcgccgcc gcggccgccg ctgccggtaa
672961 tggctccggg attgccgtca ctaccggtgc cgccgtctcc gccattgccg cccgctccgc
673021 cgttgccaat ctgcccggcg tttccgccgg cgccaccggt tccgccgtca ccgcccatgc
673081 ccctgctggc attgccgccg ttgccgccgt ggccgccggc cccaccgctg ccgcgcaggc
673141 tgccgttgcc gccgttgccg ccgttgccgc cggccgcgcc gttgccgctg agggcatggt
673201 cgccgttgcc gccgttgccg ccgttgccgc cgttgacatg aatgctgctg cttgagccgg
673261 tcgcaccgaa agtggagccg gcgccgccac tcccgccggc cccgctgggg ccggcgttgc
673321 cgccgttgcc gccgttgccg ccgatgccgt tgttggtgaa cacgctgccg ttagcgccgt
673381 tgccgccgtc accggggtcc ccgccggtgc cgccgctgcc gccgttgccg ccggcgcctt
673441 ggctgccggt tgtgcccgcc ggcccggccc cgcccggccc gccggtcccg cctcggccgc
673501 cctttccgcc ggccccgccg gcgccgccat cctggccgcg ggcacccgcg gtggcgccgt
673561 cggcgccgtc aatgccgcgg ccgccgttac cgccaactcc gccggtccca ccgtcgccgc
673621 cggcaccgcc ggggccttgg ctgccggcga cgccgttggg tgcggccccg ccgtccccgc
673681 cgtccccacc ttttccgccg gtaccgccaa ctccgccggt gccgccgggg tgcccgtccg
673741 cgcccgcgct ggaaccgttg acaccgtcgc tgccggaccc tccagtcccg ccgacgccgc
673801 cggtgccgcc ggccccgccg gtgccaccgt tgcccgccca ggcgccgccg gatccaccgg
673861 ccccaccgtt tccgccggtg ccgccatcca ggccggggtt gccgagcctg cccagaccgg
673921 gcaggccttt gctgccgttg ccgccggcgc cgccggcgcc gccgttgccg accaaaccgc
673981 catcaccgcc cctgccgccg gacgcgccgg tctggccaaa gccggtggca tcggcgcctc
674041 tgccgccgtt gccgccgttg ccgccgctgg tgggggtgtt gccgggtgcg ccgttggcac
674101 cgggggtgga gccgcttccg ccctggccgc cggcaccgcc gacaccggga tcaccgccgt
674161 ggccaccggc gccacctaca ccaccgttga caccgagcgc gccggcggcg ccgtgaccgc
674221 cgttgccagg agtcccgccg ttcccgccgg ctccgccgtc accgccagcg ccctggctgc
674281 cgttctggcc cgaggcggcc aacgcgagac cgccggcccc gccctcgccg ccggctccgc
674341 caggcccacc gttaccgcca ttcccgccgg gtgagcctgc ggccccggga gcggacgcat
674401 tgaagccgat gctgccagca cctccggatc cgccatcgcc gccggccccg ccagcacctc
674461 cggtgccgcc gtcaccggcc tgagttccgc cgttgccgcc ggccccgccg gtgccgccgg
674521 ccccgccggg gcgaccgggc gcttcggatc caaatccgag accgccggcc ccgccgcggc
674581 caccggcccc accggcaccg ccattaccca cctgaccgcc gtcgccaccc ctgccaccgt
674641 tcgcgccggt ctgtccgctg ctgatagcgt cggcgccttt gccgccgtcg ccgccgttac
674701 caccgctggt ggaggtggtg ccgggcgcgc cgttcgcgcc atgcgcgctg ccgccgacgc
674761 tggcgccacc ggcgccaccg gccccaccgg cgcccgggtt gccgccattg ccaccggtcc
674821 cgccggcacc aaggttgtga ccccacgtcc cggtagcgcc gttgccgccg tcaccgggag
674881 ctccgccgtc accgccgcta ccgccagccc cgccggcgcc gtggctgccg ccgaggccga
674941 gcagaccgtg gccgccgccg ggcccgccga ccccgccggt cccgccagcc ccaccattcc
675001 cgccgtttcc gccggcttga ccgtcagcgc ccaagttggt ggcgtgggcg ccgctggcgc
675061 ccgcaccgcc ggcgccgccg ggcccgccct cgccgccggc cccgccgttg ccgccgttgc
675121 ccatcagcac cccgccggcc ccgccggccc cgccgttgcc gccgatcccg ccggccccgc
675181 cagcggtgcc ggatccaccc ggtgtgctgg ccgacgtacc cgtgacaccg gcgatgccgt
675241 tgcctccggc cccaccggcc ccgccgacac cgaacaaccc ggcggtaccg ccggccccgc
675301 cgttgccgcc gaccgccccg gccccgccaa aacccccggc gcctccgttg ccatacagcc
675361 acccgcccgc gccgccgtga ccaccggccc cgccggtggt acccacgccg ccggctccac
675421 cgttgccgcc gttaccgatt aggcccgccg ccccgccggc cccgcctcgt tgtcctggcg
675481 ccccagaccc gccgttgccg ccgttgccgt acaagatgcc gcctggcccg ccggcctgcc
675541 cggtcccggg ggagccgtcg gcgccgttgc cgatcagcgg gcgtccgaac agcgcctggg
675601 tgggcgcatt gaccgcggct agcaaactct gttcaacgtt gaccgcctcg gcggccacgt
675661 acgagctcgc ggccgcggac agggtctgca cgaaccggtc atgaaacgtc gccacttggg
675721 cgctgacggt ctgatattcc tgggcgtgcg tgccgaacaa cgccgcaacg gccaccgaca
675781 cctcgtcggc tgacgcgggc agcactttcg ccaccgcggc cgctgcggtg ttggccgcag
675841 tgatcgtcga accaattttc gccaaatccg ttgccgccgt ggtcagcatc tccggcgtcg
675901 cgattacgaa cgacatctcg ctccccaggt caggtcagcc cggtgttgcc cggcgtggca
675961 aggaattgtg tggctatccc ggcgatctac catgtggagc gaatcttcgg gatcccaact
676021 ccaacgatcc cttgttgacg ctatcgtcaa aagggcaaaa ccccaaactt tacgcgaacg
676081 aactatccac agtgcaccct cgatttccgt cgacacgtgc aaacggccag acctcgacgg
676141 tgctagcccc gcggcgatat tgcaggtctt cgagccggtc gcgccccggg gcgcgaactc
676201 cgttgccctc ccgcgaccct gcgggagagg ataaggaatg gtcggctatg tggatgtccg
676261 ggcatacgcc gagctcaacg agttcgtgga gctgcaggcg cgcggtctga cggtgcgccg
676321 gccgttccgc agccatcaga cggtcaaaga tgtgctggag gcgatgggca ttccgcatac
676381 cgaggtggat ctcatcctgg tgaacggcga tcccgcggac ttttcctacc ggccggtcgc
676441 cggcgaccgc attgccgcct accctatgtt cgaggccctc gacatcgggt cgaccgccag
676501 gttgcgccca gcgccgttgc gtaacccgcg cttcgtcgtc gacgtcaacc tcggccagct
676561 ggcgcggctg cttcggctgt tgggcttcga cacacggtgg tcgagtgccg ccgatgatcc
676621 gacgctggcc gatatcagcc tgggcgagca gcgaattctg ctgacccgcg accgcggcct
676681 gttgaagcgc cgggcaatca cccatggtct gttcgtccac tcccagcacc cggaggagca
676741 ggcgctcgag gtgctgcggc ggctagacct caacgggcgg ctggcaccgc tatcccggtg
676801 tctgcgatgc aatggtgagc tggccgcggt ttccaaagac gaggtgattg gccagctgga
676861 gccgttgacc cgccggtact acgagtcatt cagccgctgc ttcggttgcg ggcggatcta
676921 ctggccggga tcacaccacg cacggttggt tcgcctcgtc gaacgactgc gggaccagct
676981 aactacttcg acctgacccg cacggtggtg cgcgcgtcga tcgtcgccag ctgacacgcc
677041 gaaggtgcaa ccacggcggc atcgagcggc gtgtccccgc caccaatgca cgttcggcgc
677101 ggccggcgca cgctcggcgc ggagctacga attgtcggcc ggagtcaacc gaatggctac
677161 cagcttgagc cggtccaccg cctcggcgaa ctcctcgagc gtgggtatgc gccggtcgcg
677221 gaagctcaac cccagcatgc gttggccacg cttgacgcca taggcctgtg cggcgcgcag
677281 gaaaagttca gaaacgaccg cacggtcccg gatgagctcg ccacgcatag cggtcgtctt
677341 gccgtcgtag acgacctggg cggcggcacc gtcggagaag ttgtgcttcc atccggcctc
677401 ggtcagcgcg tagaggtcgt tgtcgatgac gtgcgcgctc aagggaatcg agaagtgccg
677461 cccagtcttt cgcccggtga agctcaccac catcagctgt gtgcgtagcg ggccggcaag
677521 cggggtgtgc agcagggagc gcaggatcgg gttgacgagg cgaaggaggg ccgccggtgg
677581 gtgtgcgatg tctaccgcat acgactgatc tgtcatgcct tcaccgtaga tccgatcggg
677641 gttcgcggct acgccgacaa gttggtgacg caacaagata tatggcgcca ccggtagtac
677701 catacgtatg tggacaagac gacggtctac ctgccggatg aactcaaggc ggccgtgaag
677761 cgcgccgctc ggcagcgcgg agtctccgaa gcgcaggtaa tccgggagtc catccgggcg
677821 gcggtcggcg gcgccaagcc gccgccgcgc gggggtctat atgcgggttc ggagcccatc
677881 gcgcggcgag tcgacgagct gctggctggc ttcggtgagc ggtgatcatc gacacgagtg
677941 cgctgcttgc ctatttcgac gccgccgagc cagaccacgc cgcagtgtct gagtgcatcg
678001 atagctccgc agacgcgctc gtcgtatccc cttatgtggt agcggaactc gactatctcg
678061 tcgccacccg ggtaggtgtc gatgccgagc tcgccgtcct gcgtgaactc gccggcgggg
678121 cctgggagct cgccaactgc ggtgccgccg aaatcgagca ggccgcccgc atcgtcacga
678181 aataccagga tcagcggatc gggatcgcgg atgcggccaa cgtcgtgctg gccgaccgat
678241 accgcacgcg cacgatcctc accctggacc gtcggcactt ctcggcgctg cggccgatcg
678301 gcggtgggcg cttcaccgtc attccgtaaa ccgcaaccga ttcggtgctg caccgcggcg
678361 tgttcgtctt ccgcgtgcga tccgtccctt agggcgtgat ggtcgtctgc tcgtcgatga
678421 cgttggcggc gtccatcaac gtcatcgtct cgtcgtcgag cgcgtcggcg ttgagttgaa
678481 gcacgaacac cgcaccttgg ctgggaatca ccaccgtctt ctgcgcgacg gtccgcaact
678541 tgccgttctt gctgtatgaa ccaccgagct gccatgctga aaagccgccg agcgtggctg
678601 cacttccgtc gccgctgcct tggaagccgg gcaggttttt caactcgccg ggtgcgaatt
678661 ggaggacctt cgcggggtcg atgtcaccgg tgagtttgga gaggatcgca acgatggtgg
678721 ggggatcgtt gggatcggcg ggctgggtgt agacgatgcc gccatagggt gcgcgggagc
678781 tttccggaag cagccgccaa tcgtcgggca ccggcaggtc gatggtcggg gagccggggt
678841 cgccgtggtg cactggggtc tcctggatgt ggttgtcccg gatatagtcg gcgatggtgt
678901 agttgggccc cgctgcctga gccgaggtgg ttgccgacgt agtcgttgtc gacgtcgtcg
678961 gggacgtcgt ggttggcgac gtggttggcg cgctgtcggt cttgatgttg aaactgcagc
679021 cagccagtgc caggctcagc gccaccgtcg cgacggccgc cgtgaagtgc ttcattgcgc
679081 gctcccgaag attggaccgg cacttccggc cggtgaggtc ggattgagac tagtccaact
679141 ggtgtgcgcg cgaccctatc actgcaatcc catctcgatt gaccgcaaaa caccgcggga
679201 acaggcgtct atgcagtaag agacagctat gcgggcacgc aggttgcgca gagccctggc
679261 cgcgctcttg gcggtggcgg gtctgtttgt tccgttcatt gttggcgtgc ccacggccta
679321 cgacggtgag ccggtgttcg tcgccattcc ggtcgagcat gtcaatacgc tcatcggcac
679381 cggcacggga gccgcgatag tgggggagat caacaacttt cccggcgcct cggtgccgtt
679441 cggcatggtg cagtactcgc cggacaccgt cgacaactac gccggctacg actacgacaa
679501 cccgcattcc accggattca gcatgacgca cgcgtcggtg ggctgcccgg cgttcggcga
679561 catctcgatg ttgcccacga ccaccccgct cggctcgcag ccgtggagcg cctgggagga
679621 gatcgcccac gacgacaccg aggtcggcgt gcccggctac tacaccgtac ggttccccgg
679681 taccggggtg atcgccgagc tcaccgccac cacccgcacg ggcgtcggcc ggtttcgcta
679741 cccccgcaat gggtggccgg cgctgtttca cgtgcgctcc ggcgcatcgt tggcgggcaa
679801 ctacgccgcg acactgcaga tcgaggacaa caccacaatc accggctcgg cgaccagcgg
679861 cgggttctgc ggcaagaaga acctgtacac ggtgtacttc gccatgaagt tcagccagcc
679921 gttcagctcg tatggcacct gggacggcta cgcggtctat cccggttcac acagcatgaa
679981 ttcgagttac agcggggggt atgtcgggtt tccggccggc tcggtgctcg aggtgcggac
680041 cgccctgtcc tatgtgagcg tggacggggc gcgagccaac ctggacgccg aaggcggagc
680101 aagcttcgac gacatccgtg cggcgacatc gagcgaatgg aacgccgcgc tatcgcgaat
680161 cgcggtggcc ggcagggggc ctggcgacgt ggacaccttc tacacttgtc tttaccggtc
680221 actgttgcac cccaacacct ttaacgacgt ggacggacgt tacatcggat tcgacggtgt
680281 catccacagc gttgccagtg ggcacaccca ctacgccaat ttctccgact gggacaccta
680341 ccgcagcctc gccccactgc agggactgtt gttcccgcaa cgggccagcg acatgatcca
680401 gtcgttggtg accgacgcgg agcagagtgg tgcgtatccg cgttgggcgc tggcgaattc
680461 cgcaaccggc atgatgagcg gagacagtgt ggtaccgctc atcgtaaacc tctacgcctt
680521 cggcgccagg gatttcgacc tcaaatccgc gctgcactac atggtgaatg cagcgaccca
680581 gggcggtgtc ggacttgacg gtttcctgga gcggccggga atcgccgcct atctgaggct
680641 cggctatgga ccacaaacgg cggaattccg cgccaacggt cgtatcgccg gcgcctcggt
680701 cacgctggag tggtcggtcg atgactttgc catctcccga ttcgctgatt cgttgggcga
680761 taccgcaact gccgccgtct tccagaaccg gtcgcagtat tggcagaacc tgttcaatcc
680821 caccaccggc tatatctcgc cccggagcgc ggccggtttc ttccccgacg gtcccgggtt
680881 cgtggcatac ccctcgggct ttgggcagga cggatacgac gagggcaacg ccgaacaata
680941 cctgtggtgg gtgccgcata acgtggccgg tttggtgacc gcgcttggtg gccgcacggc
681001 cgtcgtcaag cggctcgacc gctttaccaa aaagctcaac gtcggcccca acgaacccta
681061 tctgtgggcc ggtaacgagc ccggtttcgg ggtgccctgg ctgtacaact acatcggcca
681121 accgtggaaa acccagcgga cggtcgaccg ggtccgcggg ctgttcggcc cgacacctgg
681181 cggtgcgccg ggcaacgacg acctcggcgc cctgtccagc tggtatgtct gggctgccct
681241 tggcctgtat ccgagcaccc cgggaaccac catcctgacc gtgaacacac cgcttttcga
681301 tcgcgccgtg atcgcgctcc ccaccggaaa gtccattcag atcaccgcgc cgggcgcatc
681361 cgggcggaac cgcctgaagt acatcgacgg cctgaccatc gaccgccaac cgagcaacca
681421 gacgtttctt ccggagtcga tcgtgcgcac cggaggcgac ctgaccttct cgctcgccgg
681481 cacacccaac aaggtctggg gaaccgcggc gtctgccgcg ccgccgtcat tcggtgcggg
681541 cagctcggcg gtgacggtaa atatcgcccg gcccatcatc gggatcgtgc cgggagcgac
681601 cgggaccgtg accgtcgacg cgcaacggat gatcgacggc gtcgacgact acactgtcac
681661 cccaacgtcc tacgttgttg ggattgcggc ggaaccgtta tccgggcaat tcgacgatga
681721 cggagccgtg agcgcgtcgg tcgcgatcac cgtagctcga tcggtgccgt cggggtatta
681781 cccgatctat gtcaccacca gcgccgggga tagtgcccgg acattgatcg tgctggtcgt
681841 ggtcgccgag gcggtggaat gatcattgcg caagcgcaga ggagttagat catttcgtgt
681901 ctggtcagcc agtgcatcac ctgccagccg gcgaataccg gtagccaaca ggtcaatagt
681961 cgatacagca gcaccgacgg cacacccaat gctgcaggta caccgaaggc ggcgagccca
682021 ccgatcagcg ccgcctccac cgcgccaacc ccgcccgggg tgggggcggc cgaggcgagg
682081 gtgccgccga ccatcgtcac cacggtcacc gtgacgaacg tcgttccgcc gccaaaggct
682141 tcgatactgg cccacagtgc caacgcagct ccgagcgtcg ttccggcaca accgagtacg
682201 atcaacgcca gtcgcttcgg ctcccgggcc aacgcaatga ggtcattcgt tacctccctg
682261 agcttcggcc gcaccgccgt cgctagccag cgtcgcagct tcggcacgaa gaggaatgtc
682321 ccgacaatgc ctagggccac accggcaatg aggtagagca ccgtggcatt cgggacgaaa
682381 tgagataggt cggtcgaggt gccggccagg gcgctgaaca ggatcagcag cacgaggtgg
682441 acgatcacct gtaccgactg ctgcagtgcc accgccgcgg tggcccgcac tgcggtcagc
682501 cctcccttct gcaagaaccg ggtactcaac gctagcccgc cgacgccggc cggggtagtc
682561 gttgcagcaa aagtgttggc tacctgcatg attgacagct tccagaagcc caccagccca
682621 tcagcgcagg cccacaacgc cgctgccgca ccgacatacg tcagcgccga caccgctagg
682681 cccagtagcg cccaccacca gttcgcggtt cgcagctggg aaaagaacgt gggcacggta
682741 ctgatgaaag ggtaagcgac atagaccaga gcaccgatta acaccagttg aatgagctgg
682801 ccgcggctga accgggtgat cgtttcggct ttgatctgat ccgcgcccgt ttgccgcatc
682861 acctcggcgc gtgtgctggc gatgaccgca tttgggtcgg ttatcgactc tcggattcgt
682921 tttggcacag cggatttggt aagtcttcgc gatgccgcca ggatggcttg cttgccgaac
682981 gtgtcaatgg ctgcggtcac ggcggcctcg gcgtcataca gcgccgacgt cgtcaccaag
683041 agttgggcca ggtcggattg gagttgggcg tcggtggcgc cgtactcggc ctcaccgaac
683101 ccgccgaaca gcaccgcgcc gttgtcgacg gtgatctcgg cactacacag gtccccgtgg
683161 gagatctgct ggtcgtgcag ggtccgtagc gcctcccaga catgggcagt cggcgtggtt
683221 ttggtgcatt cgctgatgcc gattccgcga gcgggccggt gtgcatacaa cgtccatccc
683281 cggtcgagcg gggacaccgc gatcaccgtc gtgttggcca tgcctagatc gccgaaggca
683341 atggccatca gcgcgcgatg ctcgaccgca cggcgcatgg aggcttgcag gggtgcggtc
683401 tcggtgccgc gcaacgtcag cttcagccag agttggcgca gcgcgccgcc gccactttgg
683461 tgcgggccgt acaactcgat caatgcctcg ctgcacgccc cggcgttggg ctgctcgcaa
683521 gcggccgaca gtaccagtgg cccgggcccg gccggccgca caaccgcgag cccggacacc
683581 gcgaatccgc gttttgccaa cgcgcgaatg gcaccatcca gtggcacttc aagcgctggt
683641 gtgccgacga ccaggaccac caacgcgccg accaaccacc ccaccgccag ccccaacaat
683701 gagcgggccg gcacaatcgc gctgacaacc agatggatcg gcacgaatgc caacagcagc
683761 gcccaccacc agtgccgcca gcgcgcgggc agccagggac ccgacacggt gagcaccgcc
683821 gcgagcatcg cgatccatcg cgggtcatcg agaaactggg ccagcaatgt ggcgagccgg
683881 tcggaaaggt caaagtgcca tcggggtgcc gcgatgcggc tactgctgat cgacaacggg
683941 agaacggcca taagtccggc ggccgcatac gcgcccagca gcttccactg ccgggaaacg
684001 atcaggccaa tcaggatcac gaacggcaac gccaaaatcg ccaggccgta ccccaggtac
684061 accagatcgg attgcgacgg ggacagcacc ccgacgatct ccgagatgga tttctccagc
684121 gccacccact gcgggcgggt gatcagcgaa ctcgtgatca ccgccacgag gtagatcgcc
684181 gccagcaccg cccggatgat gtcgttggtg cgccgggtca gtggttgcag caagttaccg
684241 gaaacgccga tgtcgcgtcc gtcaactcgc atgttctaac gatcttccga atcagggccc
684301 gcggtgtctg gtgccgtttc gcggctccgc ggacaactta gcccgataac tgcgtggggt
684361 gtcggtctga ccacttgacg tcttaccaat cttcattcac actgggcgca tggcgctgca
684421 gccggtgact cgccgatcgg tgcccgaaga ggtcttcgag cagatcgcta ccgatgtgct
684481 caccggcgag atgccgcccg gcgaggcgtt gcccagcgag cgtcggttgg ctgagttgct
684541 cggagtgtcg cgacccgcgg tccgcgaggc gctcaaacgg ctgtcggccg caggtctggt
684601 cgaggtgcgt cagggcgacg tcaccaccgt gcgtgacttc cggcggcacg ccggcctgga
684661 tctgttgccc cgattgttgt ttcgcaacgg tgagctggat atctccgtcg tccgcagcat
684721 cctcgaggcc cggctgcgca attttccgaa ggtcgcggaa ctagcggccg aacggaacga
684781 gcccgagttg gcggaattgc tgcaggattc gctgcgtgcg ctggacactg aggaagatcc
684841 gatcgtgtgg caacgccaca cgctcgactt ttgggatcat gtggtcgaca gcgccggttc
684901 gatcgtagat cgattgatgt acaacgcatt tcgtgctgct tacgagccga cgctagctgc
684961 tctgaccacc acgatgaccg ctgcggctaa gcgtccgtcg gactaccgga aactcgcgga
685021 tgcgatctgc tcaggtgatc ccaccggagc gaagaaagcc gcccaagacc tactcgaact
685081 tgcgaacaca tcgttgatgg ccgtactcgt tagccaggcg agtcggcaat gaccacccac
685141 gccgtgatca tcacctatct ccgcgaccag acgcagcccg ccgtcgatgc gatcggcggg
685201 ttctaccgga catgcgtact gactggcaag gcgctggttc ggcggccctt ccattggcgt
685261 gaggcgatcg agcagggctg gttcattacc agcgtctcgt tgctgccaac cctggcggtg
685321 tcgattccgt tgaccgtgtt gatcatcttc acgctcaata tcctgctggc cgagttcggc
685381 gccgccgaca tctccggcgc cggcgcggcg ctaggcgcgg tcacccagct gggcccgctg
685441 accaccgtgt tggtgattgc cggcgctgga gccacagcga tctgcgccga cctgggtgcc
685501 cgcaccatcc gggaagagat cgatgcgatg gaggtgctgg gcatcgaccc catccaccgg
685561 ctggtggtgc ctcgggtcgt tgccgcgacc atcgtcgccg cactgcttaa cggcgcggtg
685621 ataaccattg gcctggttgg tggtttcgtc ttcagtgtct tcatccaaca cgtctcggcc
685681 ggcgcctacg tgggcacgct caccttggtc accggtctac ccgaggtgat catctcggtg
685741 gtcaagtcgg cgacgttcgg cctgatcgct ggcctagtcg gctgttaccg cgggctgacc
685801 acgaaaggcg gccccaaggg agttggaacc gccgtcaacg aaaccctggt gctgtgcgtg
685861 atcgcgctgt tcgcgaccaa tgtggtgttg accacgatcg gcgtgcggtt cgggacggga
685921 cactagcatg gtggagtctt caacggcatc agcggcagcc gtattgcggg cccgctaccc
685981 acgcacagcc gccagccttg accgctacgg cggcggcacg gcccgaagac ttgagcggac
686041 agggactttc gcgagattca cccggatcag cgtcgtgcag atcggctggg cactgcgtcg
686101 ctatcgccgg gagacgctgc gcctggtcgc cgagatcggg atgggcaccg gcgcgatggc
686161 cgtcgtcggc ggcacggtcg cgatcatcgg ttttgtgacg ctgtccggcg gctcgctgat
686221 cgccatccag ggcttcgcgt cgctgggcaa catcggtgtc gaggcgttta ccggattctt
686281 tgccgcactg gccaacacac gcgtcgctgc gcccattgtc tccggtgtcg cgctggccgc
686341 gacggtgggc gccggcgcca ccgcacagtt aggtgccatg cggatcagtg aggagatcga
686401 cgcgctggaa gtgatgggca tcaagtcgat ttcgtttctg gtctccactc ggattctagg
686461 agggctggtg gtgatcatgc cgctgtacgc gctcgctctc gacatggctt tcacctctgg
686521 tcaggtggtc acaaccgtgt tctacggcca gtccaacggc acctatgagc actacttccg
686581 caccttcctg cgcccagagg atgtgggttg gtcggtcgtg gaggtggtga tcatcgcggt
686641 ggtggtgatg atcacccatt gctactacgg gtacaccgcc agcggtggcc cggttggggt
686701 cggccaggcg gttggtcgat cgatgcgttt ctcgctggtc tcggtggtgg tcgttgtcct
686761 gctggccgag ttggcgctct acggcgtcga cccgaacttc aatctcacgg tgtagccgcg
686821 gtgccaacgc tggtgacgag gaagaaccga cgtgcgtggc tgtatgtgga gggtgttgtc
686881 ctgctgttgg tgggcgcgtt ggtgctcgta ttggtgtaca agcagtttcg tggggaattc
686941 acgccgaaga ccgagctgac tatggtcgcc ttccgggctg ggctggttat ggaagctgga
687001 tccaaagtca cctacaacgg ggtggagatc ggccgggtgg gcagcatttc ggagattgag
687061 cgtgacggcc ggccggcggc gaagctggtt ttggacgtga atcctcgcta catcagcctg
687121 attccggtca atgtggtggc cgatatcgag gcggccaccc tgttcggcaa caagtatgtt
687181 gcgctgtccg cgccgaaaat tcctcaacag cagcggattt cctcacatga cgtgattgat
687241 gtggggtcgg tgaccaccga attcaacacg ttgttcgaga cgatcacctc gatcgccgag
687301 aaggtggatc cgatcgagct gaacgcgacg ctgtccgcgg tagcacaggc gctggatggg
687361 ctgggcggca agttcggtga gtcgatcgtt aatggcaatc agattctggc gcaattaaat
687421 ccgcggctgc cgcagctcgg ctatgatgtt cggcggttgg cggatctcgg tgaggtctat
687481 gtcgatgctt cgccggatct gtggtccttt ctgcagaacg cactgaccac tgcgcgcaca
687541 ttgaccagcc aacagcgcga tctggatgcc gcgttgttgg cggctacggg tgcgggcaac
687601 accggtgaag acgtttttgc tcgaggcggg ccgtatcttg cgcgcgcagc cgccgatctg
687661 gtgcccaccg ctacgctgct ggacacctac agtcccgaac tgttctgcat gatccgcaac
687721 tttcacgacg ctgcgcccaa agtcgcggac gcggtgggcg gcaacggcta ttcgctagcg
687781 gccgccggaa cgattttggg agcacccaat ccctatgtct atccggacaa tctgccgcgg
687841 gtgaatgccc acggtggacc cgggggccga ccgggctgct ggcagacgat cacccgggag
687901 ctgtggccgg caccctatct ggtgatggac accggtgcca gcctcgcacc gtacaaccac
687961 gtcgagctcg gccaaccgat gttcactgaa tacgtatggg gacgccaata cggagagaac
688021 acgatcaacc catgaaaacc acaggcacaa ctatcaaact cggcatcgtc tggttggtgc
688081 tgtcggtgtt caccgtgatg atcatcgtgg tgttcgggca ggtgcggttc catcacacca
688141 ccgggtactc cgcggtgttc acccatgtca gcgggctgcg ggccgggcaa tttgtccgcg
688201 ctgcgggcgt agaggtcggc aaggtcgcca aggtaacgct gatcgacggg gacaagcaag
688261 tattggtgga cttcaccgtg gatcgctcgc tgtcactgga tcaggcgacg accgcctcga
688321 tccgctacct caacctgatc ggcgaccggt accttgagct cggccgcggt cacagcggtc
688381 agcggctggc gccgggtgcc acgatcccgc tcgagcacac ccatccggcc ttggatctcg
688441 acgctctgct cggcgggttt cgcccactct tccaaacgtt ggacccagac aaggtcaaca
688501 gcatcgcctc ctcgatcatc accgtgttcc aagggcaagg cgccaccatc aacgacatcc
688561 tcgaccagac cgcctcgctg acggcaacgc tggccgaccg ggaccatgcg ataggtgagg
688621 tcgtcaacaa cttgaacacc gtgctggcca ccaccgtcaa gcatcaaacg gaattcgacc
688681 gcacggtcga caagctagag gtgctgatca ctggactgaa gaacagggcg gacccgctgg
688741 ccgcggcggc ggcacacatc agcagcgccg cgggaaccct agccgacctg ctggggcgga
688801 tcgtccattg ctgcacagca gcttcgggca cctcgagggc atccagcagc cgctcataga
688861 cgagctggca gaactcgacc acgtgttggg caagctgccg gacgcctacc ggatcatcgg
688921 ccgcgccggc ggcatatacg gtgacttctt caacttctat ctgtgtgaca tctcactgaa
688981 agtcaacgga ttacagcctg gaggtccggt acgcaccgtc aagttgttcg gccagccgac
689041 cggcaggtgc acaccgcaat gagaacgctg accgagttca accgcggccg tgtcgggatg
689101 atgggtgcgg tggtcacggt gctcgtcgtt ggtgttgcgc aaagcttcac cagcgtgccg
689161 atgctgttcg ccacacctac ctactatgcg caattcgccg acacgggtgg catcaacacg
689221 ggcgataagg tggaaatcgc tggggtgaac gtcgggctgg tgcgctcgct ggcaatccgc
689281 ggcaaccgcg tgttgatcgg attctcgttg cccggcaaga caatcgggat gcaaagccgg
689341 gcagcaattc gcaccgacac cattcttggc cgtaagaacc tggagatcga accccgcggt
689401 tcggagccgt tgaaacccaa cggtttcctg ccgttggcgc agaccactac gccataccaa
689461 atctatgacg cgttcgtcga tgtcacgaag gcggcgacgg gctgggacat cgatgccgtc
689521 aaacgctcgc taaacgtgtt gtcggagaca ttcgatcaga ccgccccgca tctaagtgcc
689581 gccctcgagg gtgtcaaggc attctccgac accgtcggcc ggcgcggcga gcagatcgag
689641 caactgctgg cgaacgccaa caggatcgcg cgcgtgctcg gcgaccgcag cgagcaggtc
689701 aacgggctgc tggtgaatgc caagacgctg ctggccgcgt tcaagcaacg cagccaggca
689761 ctgcgcattc tgctaaccaa cgtgtcggag gcatcagccc aggtatctgg cctgatcaca
689821 gacaacccca acctcaacca tgtgctggcc cagttgcgca cggtcagcga ggagctggtg
689881 aagcgcaaga acgaattggc cgatgtagcc gtcttgctcg gcagatacac cgcggccctg
689941 acagaggccg tcggttccgg accgttcttc aaggcgatgg tggtcaatct gctgccctac
690001 cagattcttc agccctgggt tgacgcggcg ttcaaaaagc ggggcatcga cccggagaac
690061 ttctggcgca gtgcgggtct gccggaattc cgctggcccg accccaacgg cacccggttc
690121 cccaacggcg cgccgccggc ggcgccaccg gtgcgggagg gtacacccaa gcatccggga
690181 ccggccgtcc cgccgggaac gccgtgctcc tacacaccgg cggcgggcgc gttgccacgg
690241 cccgacaccc cactaccctg cgcgggcgcc accgttggcc cgttcggtgg acccgacttc
690301 ccggcaccgc tcgatgtcca gccgtcgccg cctaatcccg atgggccgcc gccgacgccg
690361 ggcatcctaa gtgctgggcg gccgggcgag ccggctccgg ctgttccggg cataccgatg
690421 ccgctgccgc cgaacgcgcc gccgggtgca cgcacccaac cgcttgagcc gtttcctgac
690481 gggacgggag gtagcaacca atgagcacca tcttcgacat ccgcagcctg cgactgccga
690541 aactgtctgc aaaggtagtg gtcgtcggcg ggttggtggt ggtcttggcg gtcgtggccg
690601 ctgcggccgg cgcgcggctc taccggaaac tgactaccac taccgtggtc gcgtatttct
690661 ctgaggcgct cgcgctgtac ccaggagaca aagtccagat catgggtgtg cgggtcggtt
690721 ctatcgacaa gatcgagccg gccggcgaca agatgcgagt cacgttgcac tacagcaaca
690781 aataccaggt gccggccacg gctaccgcgt cgatcctcaa ccccagcctg gtggcctcgc
690841 gcaccatcca gctgtcaccg ccgtacaccg gcggcccggt cttgcaagac ggcgcggtga
690901 tcccaatcga gcgcacccag gtgcccgtcg agtgggatca gttgcgcgat tccatcaatg
690961 ggatcctccg ccagctcggc ccgacggagc ggcagccgaa ggggccgttc ggcgacctca
691021 tcgaatcggc cgcggacaac ctggccggca agggcaggca gctcaacgaa acgctgaaca
691081 gtttgtcgca ggcgttgacc gcgctgaacg agggccgggg agacttcgtt gcgatcacgc
691141 gaagcctggc gctatttgtc agcgcgctct accagaatga tcaacagttc gttgcgctca
691201 acgaaaacct tgccgagttc accgactggt tcaccaaatc cgaccatgac ttggccgaca
691261 cggtggaacg gatcgacgac gttctcggca ccgtccgaaa gttcgtgagc gacaacagat
691321 ccgtgctggc tgccgatgtc aacaacctcg ccgacgcgac cactacacta gtgcaacccg
691381 agccgcggga cggtctggaa accgcgttgc acgtgttgcc gacctacgcc agcaacttca
691441 acaaccttta ctatccactg cacagctctc tggtgggcca gttcgtgttc cccaacttcg
691501 cgaacccaat tcagctcatt tgcagcgcta ttcaggccgg cagccgactc ggctatcagg
691561 aatccgccga gctgtgcgcg cagtacttgg caccggttct ggacgctctc aagttcaatt
691621 acttgccgtt cggctcaaac ccgttcagtt cggcggccac tttgcccaag gaggtggctt
691681 actccgagga gcggctccgc ccgccgcccg ggtacaagga caccactgtc ccagggatct
691741 tctcgcggga cacaccgttt tcacacggca accatgaacc gggctgggtc gttgcgcccg
691801 ggatgcaggg tatgcaggtt cagccgttta ccgcgaacat gctcaccccg gaatcgctgg
691861 cagagctgct gggtggtccg gatattgccc ccccgccgcc gggaaccaac ttgcccggac
691921 cgccgaatgc gtatgacgag tccaatccgt tgccgccgcc gtggtacccg cagcccgcgt
691981 ccctcccggc tgcgggcgcc acaggacagc caggcccggg ccagtgaggt gcggcgtgag
692041 cgcgggtagc gcgaacggca agccgaaccg ttggaccctg aggtgcggcg tgagcgcggg
692101 tcaccgtgga tcggtgttct tgctggcggt cttgctggcc ccggtggttt tgacttcgtg
692161 tacctggcgt ggcatcgcca atgtgccgct gccggtcggc cggggtatgg gtccggatcg
692221 catgacgatc tacgtgcaga tgcctgacac gctggcgctg aacactaaca gccgggtcag
692281 ggttgccgac gtctgggtcg gtacggtgcg tgacatcagc ctgaggaact ggatcgcgac
692341 cctgacgctg gagctcgagc cgaccgtgcg gctaccggca aatgcgaccg cgaagatcgg
692401 ccagaccagc ctgttaggca cacaacatgt cgagctggcc gcaccgccaa tcccgtcacc
692461 gcagccgctg aaaagcggcg acaccatcgg cctgaagaac tcctcggcct accctaccgt
692521 cgaacggacc ttggccagcg tcgcgttgat cctcaccggc ggcggcatcg tcaacctcga
692581 cgtgattcaa accgagatcc tcaacatcct tgacggccat gccggtcaga ttcgcgaatt
692641 cctcgagcgg ctagccactt tcaccgccga gctgaacaac caacgcggcg atctgactcg
692701 cgcaatcgac tcaaccaacc aactcctgac catcatcgcc aaccgcaacg acacgctgga
692761 tcgggtgctc actgacgtcc caccgctgat cgagcatttc gccgacaccg gtcagctgtt
692821 cgctgacgcc accgaatcct tggggcggtt cagcgaagtc gccaaccggg cgctggcggc
692881 tacccggcct aaccttcacc agacgctgca gtcgttgcag cggccgttaa ggcaattgga
692941 acgggcttcg ccgtatgtgg tcggcgcgtt gaagctaggc ctcaccgctc cgttcaacat
693001 cgacgaggtg ccaaacgtta tccgcggcga ctacgtcaac gtgtccgcga cgttcgacgt
693061 gacgctttct gcactcgaca acgcactgct gagcggaacg ggcatctcgg gaatgttgcg
693121 tgcgctcgag caggcgtggg gacgggatcc ggacaccatg atcccggatg tccgctacac
693181 gccgaacccg aatgacgcgc cgggcggacc gctggtggaa agggctgagt gaggagatgc
693241 tgactcgcgc tatcaagacc cagctggtgt tgttgacggt gttggcggtc atcgcggtgg
693301 tggtccttgg ttggtatttc ctgcggatac ccagcctggt cggcatcggt cgatacacgc
693361 tttatgccga attgcctcgg tccgggggtc tataccgaac agccaacgtc acatatcggg
693421 gcatcaccat agggaaggtc accggcgtcg aaccaaccga gcggggcgcg cgagcaacca
693481 tgagcatcga caatggctac cagatcccca ccgacgcctc ggccaatgtg cactcagtgt
693541 cggcggtcgg cgagcagttc gttgacctgg tgtcgacccg caccagcggt ccgtatctgc
693601 ggcatgggca gacgatcacc acgactacgg tccccagcca gattggcccg gcgctggacg
693661 ccgccaaccg tggattggca gtgctgccca aagaccgggt cgcgtcggtg ctgcacgagg
693721 cgtcggaggc cgtgggcggg ctgggatcct cactgaatcg cctcatcgaa gccacccagg
693781 caatcgccca cgatgtcagg ggcagcctcg aggacatcga cgacatcatc gagcgttcgg
693841 cgcctatcat cgatagccag gtcaattccg gcaacgagat cgcccgctgg gccgccaacc
693901 tcaacacgct ggccgctcag accgcgcaga ccgatccggc ggtgcgaagc attctggcca
693961 acgcggcacc gactgccgat caggtcaacg ccacgttcag cgacgtgcgg gagtcgttgc
694021 cgcagacgct ggccaatctc gaggtcgtaa tcgatatgct caagcgctac cacaacggcg
694081 tcgagcaggc gttggtgttc ttgccgcagt ccggcgcgat cgcccagtcg gttactacag
694141 agttccccgg ccaggccgga ctgggtgtcg gcggcctggc gctcaaccaa ccaccgccgt
694201 gcctgaccgg cttcctgccg gcgtcggagt ggcggtcacc tgctgacacc agcaccgcac
694261 cgctacccaa gggcacctac tgcaggattc cgatggacgc gagcaatgtg gttcgtggag
694321 cacgcaacaa cccgtgtgta gacgtgcccg gcaagcgggc ggcgaccccg cgggaatgcc
694381 gcagcaatga agcttatgtg cccgggggca ccaatccctg gtatggggac cccaaccaga
694441 tgctcagctg tcccgcgccg gccgcgcgtt gtgaccagcc ggtgaagcca ggccaggtga
694501 tcccggcgcc gtcagttaac aatggcatca acccgctgcc cgccgatcag ctgccaggca
694561 cacctccacc ggtcaacgat cctttgcagc gacctgggtc aggcaccgtc cagtgcaatg
694621 ggcaacaacc caacccgtgc gtctacaccc cgagcacatt tcctacaacc atttacgacg
694681 tgcagagcgg caaagtcgta gcacccgacg gtgtggtgta ttccgttgag gcttcgactc
694741 atgccggagc cgacggatgg aaggtgatgc tggcaccaac cggctgagcc ggcgcgatca
694801 ggtaccggcg gattcgcgct ggtcaagaaa ggcaaccgtc agatcgttat gacctcgacg
694861 tcgggcatgg cggcgtagtc gttgtcttgg gtcaggatcg caatgccgtg cgccacggct
694921 gtggccgcaa tccagctgtc gttgatcggc acgcgcagtt tggcggcgcg cagcttggac
694981 accagtaatg cccatgcttc ggagaccgcc tcgtcgatgc ctagtggttc gaaccgttgc
695041 gcaagctggt aggtggagag ccgacgtgcg gcggcctcgg ggccggaggc ttgcaacacc
695101 ccgagccgca gctcgccgag tgtgactacc gagacgcccc attcgtatcc cgcaaaccgg
695161 tccgggtcga atcgtgtcgc ctcgatgcca atgaaaacgg atgtgtcggc gagggcgcgc
695221 cgtacgttca ccaccgcaca tcgtccgtgg tttgcgtcag cgtctctcgc agctcctcgc
695281 ccagattggt ggtatcgggg cccaagcgca ccagttcgcc gatcacctcg gcagctggca
695341 accattggcg gcgccgcttg agcggaacga tgcgcgctac ggggcgattg tccttgagca
695401 cctcgatttc ctcgccggcg gcaactcgcc gcagtacctc ggcggtgtgg ttgcgaagat
695461 cgcgagcggg tatcgtagca gacatgctac gagtgtagcg gagctgctgt cgcgccgcct
695521 cgtctcgatg tctgcggtca cgatctccgc aggttacggc cgctgctgtg cccgcagtcg
695581 cccgcgatgg tgggcccgtc ggggtagatt gcgagcgcgc ccggacggag gccgccgatg
695641 ccgaagtgcc gtgatttgtt cgaagagtta gccggcccag agcgtgctaa cgggtaacgc
695701 cgcgagcgtt gggccgaacg gggtggcttc cggcgcggcg gtgagcagca cgccgaactg
695761 aaatcgatca tcgagccgct cggccagata acgtaggcca cgcaggtcct cggctcgcgg
695821 cgtgctggtc gccttgacct cgatgccgca gacccgacca tcgggatgtt cgagcaccag
695881 atcgacctcg gcgccgccgc ggtcgcgaaa atgccacaga ctcggccgtt cggtcgacca
695941 ggtgagctgt ttgcgaatct cgttcgccac gaaagtctcc agtagcgggc cgagtggacg
696001 gccggggcga tccagcgtcg caccggtaac gccgagcagg tgacacgcca ggccactgtc
696061 cgagaccacc agtttcggtc ggcgaatcac cttgcggctc aggttggtcg accaggccgg
696121 cacccggtgg ataaggaacg ccgcttccag cagggccaga tagccagcgg tggtgcgagc
696181 cgggatcgac aggtcgttcg ccagtgcgct cacgttgagc tcggcgccgg tacgcgcggc
696241 gcagagccga agcacacgcg gcatttcggc aagccgctcg atcggcgaaa tctcgcggat
696301 caccgactgc gtcgccgtcg tgagatagtt gtcgaaccac gcgcgacgcc tcgacggcga
696361 tcgggcgacg atgtccggga agcctccggt ggcgatcctg tcgaccagat cggcgcggcg
696421 catatcggag ccgtggatca gctcgcgtgg tgcggtgaac agcgcatcga cgaaaccgtc
696481 cgcgattccg gcccgctcac cttgcgagaa cggccagagt tcgatgattt cgacccgccc
696541 gacgagcgcg tcggccatgt caggagccga gagcagcctc gctgaacccg tgagcaggaa
696601 cctgcccggc ctgcgatccc ggtcgacctc tgccttgatc gcccgaaaca gccccggctc
696661 gagctgggct tcgtcgatga cgagcgtgtc caccggccgg gatacgaatg cgcggggatc
696721 gtcgcgggcg gcgtcgcggt tggcgacgtc gtcaagcgag acgacttcgc tggatcccgg
696781 atagtcaagt cgcgcgacca gtgttgtttt gccgacctga cgcgcgccgt tgacaacgac
696841 gaccggggtg tcggcgagcg cggccagcac cgagggcgcg atcgcgcgtt cgacgactcc
696901 catgcggaca gaatacgctg ccgatttgtc tacctattgg ctgccgattc gtccccatta
696961 gcggtgcgga ttagtccaca tcatcgctgc ggatccgtcc gacggcggcc ctgagccacg
697021 tggccgacga agaacgctcg gaggcgctgc tgcgggagcg ctcgctgcac tacgtggcca
697081 gtagccgggc gggggacatg ttggtggtga cctggagcgg acagcggtcg gagttgttga
697141 gtcagctgaa gattcacgcg gcgacaacga cgtggacgcc gatcttttcg taagtgtcct
697201 tggctcgagc atcgcgtgtg gcgagttcag cccggtgctc ggcggcggca agggccacga
697261 gagcgtcata gaccgcgcca ccagtgatct cgaattgggc cagcacgcgt gggagatgtt
697321 cagtggtgcg ggaactcaac aacagcggtg ccgcaaagcg ttcggtaaga agccgcgcgg
697381 cgtccatcgg tgccagtcgt aggtcacgcg gcaggcgggt cagcacggag taggtttcgg
697441 ccagggcgtg cccgcacagc gcggcctccc gatgtgccca ccaggcgaca accgccgcat
697501 gcgcggtatg ggtccgtacc agcaacggaa tcgcgacgct ggtgtccact gccagcggcg
697561 gtttcacttc cggccgctat cgataaggcc gaacacgacc tcatcgtcga tcgtggtctc
697621 accggtggcc accagtacgc cattctcctc ttcgagacgc gctgttcgtc cggtgggaat
697681 caggtggaga ccagcgccat agcgggatat ttccacggtg gaccccggtt gcagccccaa
697741 ggcttcgcgc agcggtttgg gtacgacgat gcggccagcc gcatccacaa cagccttcat
697801 gggaatacga taccaatggc ttcccactca ggtgcggaag tcgactcacc gccgttacca
697861 cgaccccgac gaccacaccg tcagctgcgg cgcggcgtgg cgactattgg tcgctagtgt
697921 cgtgctcccg attcgggtcc tttgtatctg atgacgtgat ccgcggaagc tcctcgtgga
697981 agggcggccg cggtgtgggg agggtgatgc ggagttcggc cccgccgtcg gggtggttgg
698041 tggcgttggc atgtccgccg tgggtggtgg tgagggcggc gacgatggcc aggccgaggc
698101 cgctgccgcg accgccgcgg gcggtgtcgg cgcgggtgaa tcggtcgaag gcgacgggaa
698161 gaaagtggtc ggcgaatccg gggccgtggt cgcggacgcc gatgtcgact gcaccgtcgc
698221 gggcgtgcgc ggtgacagcg atttcaccgt ccccgtgggt gatggcgttg tcgagcacgg
698281 cggtgaggat tcggcgcagg tggtccggat cgatcgagac gaacaggtcc ggttccgcgc
698341 gtgtggtgat gtccgctcca gtagcggcga agcgggccac gctctcgtgc agcaggggag
698401 tgatcggcac cgctttggcg gaggggtggg attcggggcg gtcggcgcgg gccagggtga
698461 gcagttggtc ggccagtccg ctgagccggc gggtttcttc gagcgcggag cgcagggcgg
698521 cgctcagctg gtcggcgggt ctgggccggc gcagcgcagt tcgagttcgg tggtcagcag
698581 tgccaacggg gtgcgtaatt cgtggctggc gtcggcgacg aactgttgtt cgtgggcgag
698641 ggcccgttgc agtcgggtga gcatggtgtt gagagtcgtt gctagccaag cgatctcgtc
698701 gtcggtggga ggtaccggca gcggcgcgtc ggtgtcgggg tgcggcgtgg tggtcagtgt
698761 ttgcgccgcc gcgcggatcc ggtcgacggg ccgcagcgcg gcgcggctga gcaggtaggc
698821 ggccaccgcg gcgatgacga gcacgatcgg caggatggtc accaattccc ggaccagatc
698881 ggcggtgatg tcgtcggtga gcccgcgcag cgcgccatcg gggtcggctt cgtgagcggc
698941 gtcgcggaac tggacgacgg tgacggcgcc ggctgctgcc agaacgagcg ccatggcggc
699001 gctgaagacg agggtgagtc gccatcggat gggccactca gcgggggagc gcatgccgtc
699061 ctccgtcctt gcgcagccgg tatccggcac cgcgaatggt ttccagcgag gtgacgccga
699121 agggccggtc gatcttgtcg cgcaggtagc ggatgtagac gtcgacgatg ttggagcggg
699181 cctcgtaggc ggcgtcccag cagcgttcca gcagctgggc gcgggtgtgg acgatgccgg
699241 gacggcggat cagggcttcc agcagggtga attccttgtg actgagccgg atttcggtgt
699301 cggcacgcca gactcggtgt tcgctcgggt ccaggcgtag atcgccggcc tccagcgtcg
699361 gtgggcgtgg gatgggcccg cgccgtgaca gcgcgcgcaa ccgggcgaac agttcgtcga
699421 ggttgaacgg tttggtgagg taatcgtcgg cgccgccgtc taggcccgcg atgcggtcgg
699481 tgaccgcgcc gcgggcggta agcatcagca ccggtgtcca cacccgctgc cgtcgcagcc
699541 gcgcgcatac ctcgaacccg tcgataccgg gcagcatcac atccagcacc accgcgtcgt
699601 agtcaccgcc gtcgacggcc gccaccgcat ggcggccgtc ggcaacggtg tcgaccgtgt
699661 ggccctcctc ggtcagcgcc cgcgccagca gcgccgtcat cttgggctcg tcctcgacca
699721 ccaggatgcg cacacccgac accctgccgc atgcccggcc cgggccgcga ccagctctca
699781 tcgtcgtttc atctgccacc cctaccgtcg gagccgcaca ccgtcacagc gaggtagaca
699841 gatcaggaga aagcgatgaa tcgcatcgtg cagttcggag tttccgccgt ggccgcggcg
699901 gcgatcggca tcggagccgg gtcggggatc gcggcggcgt tcgacggcga ggacgaggtg
699961 accggccccg acgccgaccg cgcgcgcgcc gccgcggtgc aggcggtccc gggcggcacc
700021 gccggagaag tcgagaccga gaccggcgaa ggcgccgccg cctacggcgt gctggtcacc
700081 cggcccgacg gcacccgtgt cgaggtccac ctggaccggg atttccgggt tctggacacc
700141 gaaccggccg acggggacgg cggttagcat cggcgcatgc ccgcaccggg ccaccgatag
700201 cctccgggtg cgcaccgatg agatctagcg aggagaccat gatcaggcga cgaggcgccc
700261 gtatggccgc gctgctggcg gcggccgcgc tggcactgac cgcatgcgcg ggcagcgacg
700321 acaagggcga acccgacgac ggcggggacc ggggcgcatc cttggccacc accagcgatg
700381 cggactggaa gccggtggcc gacattctcg gccgaaccgg caagctgaac gatggcagcg
700441 tctacaaaat cgggtttgcg cgctcggatc tgagcgtgca gaccaagggg gtgaccgtcg
700501 cccccgcgct gtcactcggg tcgtgggtcg cgttcgcccg cacccccgac gggcagacca
700561 tgctgatggg agatctggtg gtcaccgaag acgagctggc ctcggtgacc gacgccgtgc
700621 aggccggcgg cctgcagcag accgcgctgc acaagcacct gctcgagcag tcgccgccga
700681 tctggtggac ccacatcgcc ggccacggcg acgccgccga cctggcccgt gcggtccggt
700741 cggcgctgga tgccaccgac acaccaccgc ccgcctcggc aacttccggc cagaccagct
700801 tggacctgga caccgcggcc atcgatgagg cgctgggccg ctccggcacc atcgcgggcg
700861 gggtgtacaa attcttcatc gcccgccgcg atccggtcac catgtccggc atgctcatcc
700921 ccccgtccat gggtctggct accgccctca acttccagcc caccggcaac ggccgcgcgg
700981 cgatcaacgg cgatttcgtc atgaccgccg ccgaggtcca agacgtcgtc caagcactgc
701041 gcggcggcgg aatcgacatc gtcgccatac acaaccacgg gttcgacgaa caaccacgcc
701101 tgttctacat gcacttctgg gccgagaacg acgccgtcgc actcgcccgc acgctacgcg
701161 ccgcggtgga cgccaccgcg gcccggtgac cccgcgcccc ggcgcatacc gacccgccgc
701221 gaaccaccgg tggcggacgt ggtcatgcag gcgtcgtgcg atgacgtcct cgttcaatgg
701281 gccatgttcg gccgggatcc tcgccacggc acggtcgcat ggaacgcttc ggccacggtg
701341 gccaccctat gccgcgtcga gccggggctg ccaactgttg cgcggtgagt ggtcggtagt
701401 tgtcggtggc gtgctgtagg aacagaggta tgaatctcgc ggcgtgggcc gagcgcaatg
701461 gcgtcgcgcg ggtgaccgcg tatcgctggt tccacgctgg gctcttgccg gtcccggccc
701521 ggaaggttgg tcgactcatt ctggtcgacg agctggctag cgaggctggc gcgcagccaa
701581 agactgcggt gtacgcgcgg gtgtcgtcgg ctgatcagaa gtctgatttg gatcggcagg
701641 tggcgcgggt gacttcgtgg gccacagccg aacagatccc ggtcgacaag gttgtcaccg
701701 aggtcgggtc ggtgctcaac gggcaccgac gtaagttccc tgcggtgctg cgcgatctgt
701761 cggtcacgcg gattgtggtt gagcatcggg atcggttctg ccggttcggt tcggagtatg
701821 tccacgctgc gctggccgct cagggtcggg agttggtcgt ggtggactcg gccgaggttg
701881 acgatgacct ggtatgggat atgaccgaga ttctgacctc gatgtgcgca aggttgtatg
701941 gcaaacgtgc tgctcagaac cgggccaagc gggccgtcgc ggctgccgct gtcgatgatc
702001 atgaggcggc ctgagatgcc gcgtttggag atccccaacg gctggtgtgt gcaagcgttc
702061 cggttcacac tcgatccgac cgccgagcag gcacacgcgt tggcgcggca tttcggcgcc
702121 cgccgcaagg cctacaactg gaccgtcgcg cagctgaaag ccgatatcca agcgtggcgc
702181 gcgaccggcg cccagacggc gaagccgtcg cttcgggtac tgcggaaacg ctggaacacg
702241 gtgaaagacg aggtgtgtgt caacgccgag actggcaccg tgtggtggcc ggaatgctcg
702301 aaagaggcct acgccgacgg gatcgcgggc gcggtcgacg cgtactggaa ctggcagcag
702361 aggcgtgctg gcaagcgcga cggcaagaga atgggcttcc ctcgattcaa gaagaagggc
702421 cgcgacgccg atcgcgtgtc gttcaccacg ggtgcgatgc gcgttgagcc cgaccgtaga
702481 cacctcactt tgccggtgat cggctgcgtg cgtacgcatg agaacacccg ccgcatcgag
702541 cgcctcatcg ccaaagaccg ggcgcgggtg ctggcgatca cggtgcgccg caacggcacc
702601 cggctggatg cgagtgtgcg ggtactggtg cagcgccccc agcaacccaa cgtggaactg
702661 cctgagtcgc gaatcggtgt cgacgtgggt gttcgtcgtc tggccacggt cgccaccgcg
702721 gacggcgcat gctgcccggt cctggtgcca gacggctaac gctgggcatt atccccgagg
702781 gcggcgccca tatcgacgtg ccccgaaaga ccgtgggcgc ctggcaaaca gccgacacca
702841 tgggcatctt ccaggccctt cccgacgtct ggggcgggtg gcggaccgaa tgctgggaag
702901 accgcttcga agagcagctg attcgatgca acggggcgct gcggcttccc gagctggatt
702961 tggccgcggg catggacagc gcccgggagt ggctccgtga caggatattt cagcgcttct
703021 cggacagccc ggcaggccaa attctgaaac tctccgagct gctggccgat gtcggacccg
703081 gtctggtcgt cagcgacgat gccgtgacga atggcggggc tcgcccaaac aacgaagagt
703141 gggcgcgttt cgttgcggcg tgcgatctgg tgcgtggggc tcacgccgaa tcggcctgac
703201 ttcggggata gtggtaccat cactttggta gaagggtact aacatggcgt tgaacatcaa
703261 agatccgtcg gttcaccagg cggtcaagca gatcgcgaaa atcaccggcg aatctcaggc
703321 tcgggcggtg gcgaccgcgg tgaacgagcg tctggccaga ctgcgcagcg acgatctcgc
703381 cgcccggctc ttggctatcg gccacaagac cgcgagcagg atgagcccgg aagcaaagcg
703441 cctcgaccac gatgctctgc tgtatgacga gcgagggctg ccggcgtgat cgtcgacacg
703501 tcggcgatca tcgcgattct gcgcgacgag gacgacgccg cggcctacgc cgacgcgctc
703561 gccaacgccg atgtccgcag actgtctgcg gccagctacc tggaatgcgg gatagtcctt
703621 gactcccagc gtgatccggt catcagcaga gcactggatg aacttatcga agaagccgag
703681 ttcgtcgtcg agccggtaac cgagcgccag gcccgcctgg cccgagcggc ctacgcggat
703741 ttcggcagag gcagcggcca ccccgcgggc ttgaatttcg gcgactgcct gtcctatgca
703801 ctggcgatcg atcgacgtga gccgctgctg tggaagggca acgactttgg gcacaccggc
703861 gtccaaaggg cactggatcg gcggtgatcg acgtcagcct ggcgcggcgg tgcgaggctc
703921 acgggtacga ctattttcgt tccgacgatc cggtggcagc ggcgggcttt gtggtgtccg
703981 ctgtgtggag ttgtgggcgt ggacctggga acgccacggg ttccgggcgt ttgccgaaac
704041 cgctgcgcca cagttgattt ggcgggagta cagacccggc tggacccgat acggcgacgg
704101 atctgtggcg caggtcaaat cgatcttcga cgctccgcgc ggttacctca atgcggcgtg
704161 tcgtcggcgt gttgtacatt gggcatcggg actcctgaga aggatcctgt aggccgcagc
704221 cccacccacg ggtggggctg acgtgcgtcc aagggggcca gatctggcag accttcatct
704281 tgtttgcgac gatgtcccat aatcgttggt ggtcttcacc gaccgggcgt ctttgacgtc
704341 tgaccgacgc ctccgaaagt ggaggtagga cacaaggtcg gcagcttgca gcaggcgacg
704401 gtgtttcgag ggcgcgaaat gcagtgcgtc gacgcccgct attcctcacc gccgcggttt
704461 cctcggtggc aatctcactt cgtcgagccg cgggcacggc tttcgagata gaggtcgata
704521 tgcccacaag tctcgcaggc aacggcgttg acctgggtgc cgcgattgaa gtggccggca
704581 ccttcgcgct tgaaacgcag cggcgcgttc cagacgacgg ccccttcgac gagctggtcg
704641 cccccgcatc tcacgcactt ctcgtcggtc acgacgcctc cccttctctg cggctggcca
704701 ggctacgccc agcgcttgat gcccaggaaa tccacggcgc cgccgctagt ttcacctgaa
704761 cgacgccgcg cgatcacgaa gctttcggat cgcccgtgcg gtaaacgctt gcggctccag
704821 atgccacagg tgcgcgcctt caggtgtgcg caacgccgcg aaaggaaccc gctcaccaca
704881 cacgagcttc tccagctcga gtgcccagcc tacggccagg gcggcacgct gccggtgcca
704941 ggcgtcagcg cgccacgtca gccggggcaa gccggcgagt ttgctctgga tgctttggcg
705001 gagtttgccg gcgcagagga tccgggacgg aaccgagccc agaccttcgg tgtcggacgc
705061 cggagcgacg cgggtgaacg cgatctcccg gcggtcgtag ttccaccagg cgcgcgcgac
705121 ggtgacctcg ccgaccgggg tcgcacggtt ggacagttcg cgcttttctt gacgcgcccc
705181 atgctgatcc agccacagat ggatttcggc aaccgtgcgg gcgggcagtg gctcggcgtt
705241 cgggcgcgga tcgcatccgg cgaccagcat cgcggggacg tgcggcggcc acagctgggc
705301 gagtggacgc agcggattga gccgaacgcc gtcgaagtcg ctgcgtttgg cgaggtcgcc
705361 ccagagtgcg ggacccaacc gcacgacgtc gagtccgcgg tgtcgctcgg ttcgccggaa
705421 tgtcgccgcc gcgtccggcg cggtcatgat cgtgatgacg tccaacccgt cggcgcggtg
705481 aacggcgggc cggccggtgc ccggggagac ggcaacccac cacggccctt cgtacagcaa
705541 atcccgctgg ccggggcccg gtttggcaac ggcatcctcg agctcgaccg tgcgcgccca
705601 gttctgcagc tcgggcagcg cacccggccg gaacgccgaa ccccacggtt cgtcgggatc
705661 gaatgacagg ccaccgacga gcggagcgat gtcgcgaacc agttccaggc cggaatattc
705721 gcggccgtcc gacgccgaac tctcggcgat gagcatcggt gtgccgtcat cgagcgccac
705781 ggtctcgagt tcgccgtcta tctcggcgac ccgccacttc gggtagcgca gtatcgcgcg
705841 ccgcgcgtcg tcggcggaga gttctccgcg cgcatatcgg gccagtaagc cccgtagctc
705901 gtcgtccatc ggccatcacc cggtcgggtt gcagcatccg ccacagaaca aagcggacga
705961 ctacgccacc tcgcggacat gcggaatctc ccgccgccgt cgtggtcgga tatcgtcgcc
706021 ggccaacgtg acgaccgcta ccgtgcagcc gttcgcggcg gtaaagtcga cttcgtagcc
706081 acccgcggcg tagcgcccga cgacggcacc gacgtctccg gcgatgaggg atttgtcggg
706141 aacatcccgt gttagcacca caacatcgtg ttctgcgtac atcggtccgc tcctagcgtg
706201 gataggcggt aaccaatcga ggcacgccgt cgggttcgtc gctgatccac actgtacgca
706261 atgcaaccat ccggccgcac cgtgattcca cgacaccatc gacgattgcc gtgacgccgt
706321 agggtgttgg ggccgatccg gcaaccgcgc ctgacggtgc ggccagggcg gctgccgggg
706381 atgatcgccg gcgtggcggc gaaacgaatg aaccgcgaac agttcttccg cgcggcgtcg
706441 gggctcgatg aggatcgcct acggaaggcg ctgtggaacc tctactggcg cggcaccgca
706501 aacatgcggg agcgcatcga ggccgagctg gccagcgccg ggcgcgctcg cccggcgcgc
706561 aaaataaagc cgccggccga tccggacatc gtgggttggg aggtcgacga gttcgtgtca
706621 ctggcgcggt cgggtgccta cctgggcggg gaccggcggg tgtcgccgcg ggaacgatcg
706681 cgctggcgtt tcaccttcaa gcggctcgcc gcggaagccc aggacgccct gcgagccgag
706741 gacgccgagc ccgcggcatc cgcactggag caactgatcg acctggcgcg cgaggccgac
706801 gggtacgact acttccgctc cgacgatccg gtggcagcgg cgggtttcgt cgtgtccgat
706861 gtggcggcgg cgggccaccc acacttccgt gagttcgccg ccgagatcgg tgcggcgatc
706921 ccgccgtgag taccgcccgc ccggctacta caagcccaaa gcggtgcgca gccggtcggc
706981 gtccatcccg ccacgggcgc ccgcgccggc gggaaacgtg tccaggagct tgatcaggtc
707041 ggcgcggcgg gtggggtcgt cggcggcctg ccgcggcgtg tgcccgtcca gcgcggggat
707101 gggttgatcg agccagctgg tctcgtagtc gcggatgaat tcctcgagcg cggcggccag
707161 ctcggggctg tcggggtcgg gcgcgcccgc gccggtaact ggcatctgct cggccagcgc
707221 ggcggcctcg cgggtgttgc gcagcggacg gcggtcgtcg tcgagcaccg tcatcgccgg
707281 gtcgaggcgg gtcagcgtgg ccagcacgcg atccatccgc ggttcgctgt tggtttccac
707341 ccgcagcgtg tcaccgtcga ggaccagcgt ggcccggacc cgcagcatgc cgtcgttggt
707401 gacgtgttcg atccaccgcg gcggctcctc gccgtcaacc cggtcgtaga ccccgtcgag
707461 cgcgccctgg atcccggccg gatcgtcgac tcgcacgctg gcctcgcaga ttgccagcga
707521 gtcgccctcg gtgttgacca gtgtcggcgg cgcgaaccgg cggctcagct gggccaccag
707581 tgtcaccggg tcgggctcgt catcgagcag ctcgatcagc acggcacgct cgtgcagcgc
707641 gaccggctcg atcccgccga agaacaccat ggtgtccccg gcgggcaccg ggcgcgcgca
707701 gatcagctgc ccggctcgca gctggcggct ggccgcccgc tcatgcacct catgggtgtc
707761 gccggtgcgt acgtcgcgca cgatcacgcc ctcgccaggt tgcacgtgct cgacctcgaa
707821 caccgaccgc tccacgagca gccattgctc ggcaagcagc cgctcgtcgt cgggtagcag
707881 cgaaccgcgc acttcgagga actccgcgaa cgcgccgccc tcgaacaaca ccgcgtccag
707941 caccagcgga tcggccagcg ccgcggccag cgcgtcctca tcgtcagagt cggcataccg
708001 gaagcgctca tagctgactt cggccagcag gccggtccag tcgcccgaca gtgcgtgctg
708061 ggatgccttg gcatacagcc agtccacccg ctcggccagc ggcagcgcct cacggccgag
708121 atggcatttc ttgtacttgc ggcccgaccc gcaccagcac gcctcgttgc ggcccaggtc
708181 gcggcgcggc tgggctcggt gccgctccag gagccgcacc agcgggtggt cgggttcggt
708241 gccggcgcgg cgcagcagtg ccaacccgcg ctcggcgtcg ccgcgatcgg aggcgatgcg
708301 ggccaggtcg agcaacggca gcggccactc ggtgtccatc gactcggccg ccagcagctc
708361 acgttcggcc gcctcgacat caccgatccg gtccagcgcg accgcgcgca gccagcgcac
708421 cgccacccgc gccgcgcgcg gcaccttggg ctccagcatc tcggtgagca ggcccagcgc
708481 ggccgccccg ccggagtcgg tgcccaccgt ctctgccacc agcagctcgg ccagcagcgg
708541 gtcggccagc gccgccccaa tgtcgccgag cagatcgacc aacgagtcgg agccggtttc
708601 cgtcgcggtc tcggcggctg tggcgagcac atcccgcggc aactcgtccg ggtcggttgc
708661 ttcgagcagc agcgacatcg tctcgtgcag tttgatcagc gtgtacagcg cgaccgcgtc
708721 gttggggtcg aggtcgtggc gaaaggccag cagttcgcat cggttctcga aacgccaagc
708781 gtcgaaattg aatccgccag gtgctagcca gtcgtcttcg tgcgtgaggc cgtgctggtc
708841 gaggatctcg cgcagcggtg ccactggctc ggtaaatgcc gccgggtcgt cgacgcacgc
708901 cgtccagacc gccgcgggga agaacgcggg ctcgtcgggg tcgaccagct cggccagccg
708961 ggcgccgacg gaggtgtccg caccggctgt gccgatccgc tcgagcacca gccctgcggc
709021 ggtcagccgc acaccgacca gatcccccgc ggcggccccc aacgtcgcca gcgtgcccgg
709081 ctccagcagc agtgccccgc cggggtcgat ggcctcgtcc gggatgcccc gtcgttcgag
709141 cagctcctcg tcgtatccgg ccagcacgat ccgcgccgcc gaaccgtcgg ccagccggcc
709201 atactcctcg tgctcgcaga gcgtggtgat cgggtccagg tccggggtca cgccgagcat
709261 gtcgtggacc gcctcgtccg cgccgagccg atgggtgaat acccgcccgg ctagcagcgt
709321 cggcagccac acccaccgat cgtcgaccaa ctgccttgcc ggccattccg tttcaaggcg
709381 aagcgcgcgc aggacggcgt ccgggtcggc cacgccgctg tccagcaggc gtcgtgcgat
709441 gtcgtcctcg ctcaatgggc catgttcggc caggattctc gccacggctt gggtcgcatc
709501 gaacgcttcg gccacggtgg ccaccttatg ccgcggccag ccgaggcttg acgtcgggca
709561 ccagccgatg gggctggcct cgcctagggt tcggcgttgt gacggcgccg acgcggtgga
709621 ccctggccga cggacgtgag ctgctgttct tttcgctgcc cgggccccgc accagcggca
709681 ccgccgcaga acgggtggct cgccacgctc aagcgcaaac gttcgccggc gatatccgcc
709741 agcgcgccat acagctggtc gtgtccgaac aagaagtggc aagcaaaatc accgccgcta
709801 ccgccggaat cgccaccacc accttcccgg aaacacccag catcgacgac accatcatcg
709861 gcaacgacaa ccgcgacact ggggtccggt tggtcgacgt caaacaagat ggcggcacta
709921 gtcccccgcc cccatttgcg ccgtgggaca cccctgatgg aacaccgccg ccgggcactg
709981 gcctaagccc tacgctgcag cagatgatcc tcggcggtga tccagctaat ctgaccggcc
710041 agggtcttgc ggacaacgtg caacggttcg tacagtcgct gcccgcaaac gaccccaaca
710101 cagcgtggtt gcgcggtcag gttgcggatc tgcaggcgca cgtcgccgat attgagtacg
710161 cccgcaccca ttgcagcacc aacgactgga tcgaccggac cgcccagttc gcctcgggcg
710221 ccatagtctt cagcatcggc gtgttgaccg cagagaccgg ggcgggggtc gtggctgccg
710281 cggccggtgg tgtcggcgcg gccacggcgg gcgtgagtct tctacaatgc ctggtgggga
710341 gcaagtgatg gacgtattgg ctgctgggat cgcggctggc gcgctcacgc tggcggcgtg
710401 gggcgcctgg cgcccgcact accgggcggc gtcctacctc gtggccggtg ccgtagagct
710461 ggcactgatc gggctgctgg tggtgaccgg gcaaacattg atggccatct cggtggcctt
710521 ccttgtggcg ctgggcggtc cgttggtggt ggtcaaccac cgcagagctg aacgcagccg
710581 aggttagatg aacgaagagg gcctgtaggt cgcactcatc gcgcggctag cctgtgaggc
710641 cagccctcgg gccgccaccc aacacggctc gtgcgctgtc tcggccggct cgtctgccgc
710701 acggccagca tgatcagtcc cgttggaata ccggtgagcg tcggcgcgcg catcacgatg
710761 cagcgatgtt aggatgaggc ggtgcgcact accatcgacc tgccgcaaga cctgcacaag
710821 caggcactgg cgattgcccg ggatacgcac cgcacgttga gtgaaacggt cgccgacctc
710881 atgcgacgag gcctggccgc caaccgccct accgcgttgt cctcagaccc cagaacggga
710941 ttgcctttgg tgagcgtcgg gaccgtcgtg acctccgagg acgtgcgttc attagaggac
711001 gagcagtgac ggtgctgctc gacgccaacg tgctgatcgc attggtggtc gccgagcatg
711061 tgcatcatga tgccgcagcg gactggctca tggcgtccga caccggattt gcgacctgcc
711121 cgatgacaca aggaagcctg gttcgattcc tggtgcgctc gggacagtcc gcggcggcgg
711181 ctcgggatgt cgtcagtgcg gtccagtgca cgagccgcca cgaattctgg cccgatgcac
711241 tctctttcgc cggtgtcgag gtcgctggtg tggttgggca ccggcaggtg accgatgcct
711301 accttgccca gctcgcgcga agccacgacg ggcagttggc gacgctcgac agcggcttag
711361 cacacctgca cggcgacgtc gcggtactca ttccaacgac cacctgatgt gcatcgtctc
711421 ccggcggcgc ggcgagccgc cccaaaacca acgattgggc cacgatgcgt aggcatagct
711481 gaggtggcgt cgcggccctc accggcgaca ccacagagga tctcgggccg atccgatgag
711541 cgccacgcca ccgcccggag gactcgacgc gtcggtgttc atcgcgaacg aacgcggtcg
711601 gcaactcgac gaggcgctcc cagtagggtt ctgcgttgtg acggcgccga cgcggtggac
711661 cctggccgat ggccgtgacc tgctgttctt ttcgctgccc ggacacgtcc cggcgccggt
711721 gtcggatcgt cggccgctgc ccgaacgtga cccggctccc tcgcggctgc ggttcgaccg
711781 ggccaccggc cagtgggtga tcgtcgccgc acagcgccag gatcgcacct acaagccgcc
711841 ggccgcgcgc tgcccgctgt gtccggggcc gaccggtctg agtagcgagg tgcccgcccc
711901 cgactacgac gttgtcgtct tcgagaaccg gtttcccagc ctggccgggg ccggcatcgc
711961 cccaatcggc gcgcccgacg gtgacgggtt cgtatccgct ccggggcacg gacgctgcga
712021 ggtgatctgc ttttcggccg atcacaccgg ttcgttcgcg ggcctggacc cggcgcatgc
712081 ccggctggtc gtgcacgcgt ggcggcaccg caccgccgaa ttgacggcgc tgcccggggt
712141 agcgcaggtg ttctgcttcg agaaccgtgg tgaggagatc ggggtgaccc tgcccacccg
712201 cacggccaga tttacgccta tccgtatctg acgccgcgca ccgcggcgat gctgcgccag
712261 gctcgtcggc accgaaagcg tcacggtgac aacctgtttg ccagcctgct ggcacgcgag
712321 gtcgccgacg gcagccgcat cgtggtacgc ggcgagctgt tcaccgcatt cgtaccgttc
712381 gccgcacgct ggccggtgga ggtgcacatt tacccaaacc ggttggtgcg caacctcacc
712441 gagctcaatg acggggagtt ggatgagttc gcccggatct atctggacgt gctgcagagg
712501 tttgatcgga tgtattcttc accgctgccg tacatgtcgg cgctgcacca gttcagcgag
712561 gtccagcgcg atggctactt tcacgtcgag ctcatgtcga tccggcgcag cgccaccaaa
712621 ctgaaatatc tggcggccgc cgagtcggcg atggacgcgt tcatcgccga cgttatcccg
712681 gagagcgtgg ccacccggct gcgcgagctg ggcccatgac ggtcagctac ggcgcacccg
712741 ggcgggtcaa cctgatcggc gaacacaccg attacaacct gggtttcgcg ctgccgattg
712801 cgttgccgcg gcgcaccgtt gtcacgttca cccccgagca caccggcgcg atcaccgcgc
712861 gcagcgaccg cgccgacggc tcggcgcgga tcccgctcga caccacgccg gggcaggtga
712921 ccggctgggc agcctatgcg gccggggcga tctgggcgct gcggggcgcc ggccacccgg
712981 tgcccggcgg ggcgatgtcg atcaccagcg acgtcgagat cgggtcgggg ctttcgtcgt
713041 cggcggcgct gatcggcgcg gtgctgggcg cggtcggcgc cgccaccggc acccgcatcg
713101 accgtctcga gcgggcccgg ctcgcacagc gagccgagaa cgactacgtc ggtgccccaa
713161 cgggtttgct cgaccacctg gccgcgctgt tcggagcgcc gaagaccgcg ctgctgatcg
713221 actttcgcga catcaccgtg cgcccggtgg ccttcgaccc ggacgcctgc gatgtggtgc
713281 tgctgttgat ggattctcga gcccgacact gtcacgccgg cggggagtat gcgctgcgcc
713341 gggcgtcgtg tgaacgggcg gccgccgatc tgggggtgtc ctcgttgcgc gctgtgcagg
713401 atcgcgggct ggcggcgctg ggcgcgatcg ccgatccgat cgacgcgcgc cgcgcccggc
713461 acgtgctgac cgagaatcag cgggtgctgg atttcgcggc cgcactggct gattcggatt
713521 tcaccgccgc cgggcagctg ctgaccgcgt cgcatgagtc catgcgcgag gacttcgcca
713581 tcaccaccga gcggatcgat ctgatcgccg agagcgccgt acgggccggt gcgctgggcg
713641 cccggatgac cgggggcggc ttcgggggcg ccgtgatcgc actggtgcct gccgataggg
713701 cgcgcgacgt ggccgacacg gtgcgacggg cggcggtcac cgccggctac gacgagccgg
713761 cggtgagccg gacctatgcc gcgcccggcg cggccgagtg ccgttgagcg ggttggcgaa
713821 gcgtcatgtc cacagtgagc agatcggtgc gggtccgcca ctgcccttga cctcgaagcc
713881 gaacaccggc tacgagaccg ctgccgcggt ggatctggtg tctggggctt agcccgcttc
713941 gctgataccc agaaccagtg cgagcgcgtg gtcggtctgg cgcatcctgc caggtgccag
714001 ggctcccaat cgttcgagca ggcgggtgac gaggatcgcc gactggtcct gcgcgcgagt
714061 attggttgtc gccgcggtat cccggggcca tgaagacgca gccttcgatc ttggcttcgc
714121 tcgactcccg atgccgcccc aactcgatcg ctcttgggtt tgtccgaccg cgggcgtagc
714181 ctttgcctcg aggtgcagcc gatggcaggc gatcgaggcg ctgaccccgg tccggcgaat
714241 gtgactccgg gtgcggatga ccatgcacag catgcgtcgc cgacggtgct atgtccccag
714301 ggtcacgtga acgcatggga ctacaggttc tgtgagcggt gcggctcgcc gatcggcgtg
714361 gtgccctggc cgtcggagga atcaggcaca cgccagacgg cgcccgcgcg atccttcgtc
714421 cccctcgtcg tcctcgcggc gacgctgctc gtggtcgccg tcgtcgtgac ggccgtcggc
714481 tacgcggtga cgcgaccggc tcgcaacgac cgtgaggagc ccagttccgc gcggggcgcc
714541 gccacgacgg gtgtgccgtt cgcacaggcc gaggccgcga gttgcccgga cgatccggtg
714601 cttgaagcgg agtcgatcga cctgacgtcc gacgggcttg cggtgagtgc cgcgttcatg
714661 tcggcatgcg ccggcggcga tgtcgagtcg aactcggcgc tcgaggtcac cgtcgccgac
714721 ggacggcgcg acgtggcggc cggaagcttc gacttctcgg cagatccgct gaggatcgag
714781 cccggcgtgc ccgcccgtcg aaccctggtc tttccgcccg gaatgtattg gcgaacgccc
714841 gacatgttgt ccggcgcacc ggcattggcg gccacacgga agggcaggtc cgatcgttcg
714901 gccgcacgag gcggatcggc acggacgacc atggtcgcgg ccgcgtccgc ggcaccggct
714961 tacggcagca tcaacgccgt tgccggggcg gtgctggtgg agctacgtga ctcggacttc
715021 ccctacgtgc gagtcggtat cgccaatcgc tgggtgccgc aggtgagttc gaagcgcgtc
715081 ggcctggtcg ccgcggggaa aacgtggacg agcgccgata ttcttcgcga tcacctggcc
715141 ctgcggcagc ggttcggggg cgcccgcctg gtgtggtcgg ggcactggac caccttcagc
715201 ggacccgatt tctgggtgac ggtggttggg ccggcgcagc ccaccgcagc tgaggccaat
715261 cgctgatgcg actcgaacgg gttcggcgcc gatgactgtt tcgcgaagtt catcagcacc
715321 ctcgttggcg cgaagggcac gacggtgtac cggaagtgac gacgctgcca tgagtttctg
715381 cgtgtattgc ggtgccgagc ttgccgaccc gaccaggtgc ggggcgtgcg gcgcatacaa
715441 gattggttca acctggcatc ggaccacgac gccgacggtc ggcgccgcga cgacggcaac
715501 gggatggcga cccgatccca ccggtcgcca cgagggacgc tacttcgtcg ccgggcagcc
715561 gaccgacctc gttcgcgagg gcgacgccga agccgttgac ccacttggtc agcagcagct
715621 ggatcagtca ggtgccgttg gtgtttcgcc gtcagcggtg tcggggtggg tgcgttctgg
715681 gcaccgtcga ctgtggtggg cgcttgcggg cgtggtggcg tttctcgggc tggtgggagc
715741 cggtgtcgtc gggacgctgt tcctgaatcg agaccgggag tccatcgacg acaagtacct
715801 cgccgccttg aggcggtccg gactcaccgg tgagttcaac tccgacgcga acgccatcgc
715861 ccgcggcaag caggtgtgcc gccagttgca agacggtggc gaacagcagg ggatgccggt
715921 cgatcaggtc gccgtgcaat actactgccc gcagttcagc gatggcttcc atatcctgga
715981 aaccataact gtcactggaa gtttcaccct caaggatgaa tcgccaaacg tgtacgcacc
716041 ggcgatcacc gtgtcgggct ccgggtgctc agggtcagcc ggctacgccg acatcgaccg
716101 gggaacgcag gtgacggtga aaaacggtca gggggacatc ctggccacgg ccttcctgca
716161 ggcgggtcag ggcggccgat tcttgtgcac cttccctttc tcgtttgaaa tcaccgaggg
716221 cgaagaccgc tacgtcgtgt cggtcagtcg tcgaggcgaa atgagttact cgttcgccga
716281 tctgaaggcc aatgggctat cgctcgtctt gggctgagtc accgcggtat tcggcacggc
716341 gcaccgctgc gcaaccagct agcgctgacc gtgtgatcta gaatctagct actagtatag
716401 aatcgagaca tggcgctgag tatcaagcac ccggaagccg accggctcgc gcgagcgctt
716461 gcggcgcgca ccggcgagac gttgaccgag gcagtggtta ccgcgttgcg cgagcggctc
716521 gctcgtgaga ctgggcgtgc ccgtgttgtc ccgttgcgcg acgagcttgc cgcgattcgg
716581 caccggtgcg cagcgttgcc ggtggtcgac aaccggtccg ctgaggcgat tctcggctat
716641 gacgagcgcg gattgccggc ctgatggtga tcgacacgtc cgcgctcgtt gcgatgctca
716701 gcgacgagcc agacgcagag cggttcgagg ccgccgtcga agccgaccac atccggctga
716761 tgtcgacggc gtcttacctg gaaacggcac tcgtgataga agcccgcttc ggtgaaccgg
716821 gcggacgtga gctggatctg tggcttcatc gcgccgcggt cgaccttgtt gccgtgcatg
716881 ccgaccaagc ggatgccgcg cgcgccgcct accgcacgta cggcaaggga aggcatcgtg
716941 cggggctcaa ctacggcgac tgcttctcat acggcctcgc caagatcagc ggccagccac
717001 tcctgttcaa gggcgaagat ttccaacaca ccgacatcgc cacggtcgcg ctgccctaat
717061 tcttagtcag ccaggtgttc gccgcaccgg ctttcggcag cgtcaacggt gttgttaagt
717121 gcggcagaag gttcacaagg catgtcgacc gctcagcgtg ctccgacttc gcgatccgga
717181 tcctcgacgc cgccgtccgc gccgtcgcca cgggcgtgtg cacgccactg gcggtacccg
717241 tgtcgcgccg cgaacgcacc gatgatggcg gtgacgcacc acaccgcgat cgcgcaggac
717301 gccagcagcg gtgagcgatc gccgatcgcc gcacccaatg cggtgtaggc gaatgcccgc
717361 ggcgcggaac cgatgaatgc accgacggcc atctgccaca acggaactcc gaacgtcccg
717421 aacgcatagg aggcgaacgc atccgatatg ccggggacaa agcgttggcc gacgacggcc
717481 cacaggccgc atcgttcgat cagcgcgtcg gtgcgatcgg cacgttcccc gcccagcagg
717541 gctcgcgcgc tggcccggcc ggctcgacgg ccgaccaggc tcgcgacaac ggcggtgccc
717601 accgtggcac ccagcgtcac gaagaccccc actagcggac cgaacagcag cccgctgctt
717661 gcggccagga tcgggcccgg gacgaacaac gcgccgagca cggccgacac tacgacatag
717721 gtcagcggcg ccgccggccc ggtcgccgag accgcgcccc gcaccgcggc cacatcgatg
717781 acgtccgtgg cggctaccag gtagaacatt cctacaagga agccggcgaa cacgacaagc
717841 cgcacgatgt ggcgtcgccg ggatgtcggt gcggaatcgt tgtgagtgct catgctgacc
717901 gtgattgttc cgcaccgacg ctggccgcgc ccgtcgtccc cggcgttggc tggggaacct
717961 cggctgcgcg ggcgccgtcc ggcgagcaac ccgtttgtcc tacgattgag ctacgatcgt
718021 aggcatgtct gaggtggcct cgcgtgagct gcgtaacgat acggccggcg tgctgcgccg
718081 cgtgcgggca ggggaggacg tcaccatcac cgtcagcggc cgtccggtcg cggtgcttac
718141 cccggttcgt ccgcggcgcc ggcgttggct gagcaaaacg gagttcctgt cgcggttgcg
718201 cggcgctcaa gccgatcccg ggctccgtaa cgacctcgcg gtccttgccg gcgacacgac
718261 cgaggatctc gggccgatcc ggtgagcacg acgccggccg ccggagtgct cgacacgtcg
718321 gtgttcatcg cgaccgaaag cggccggcaa ctcgacgagg cgctgatccc cgaccgggtc
718381 gccaccaccg tcgtcaccct cgccgaactg cgcgtcggcg tgctggccgc ggcgacgacc
718441 gacatccggg ctcaacgcct ggcgaccctg gaatccgttg ccgatatgga aacgttgccc
718501 gtcgacgacg atgccgcccg aatgtgggcc cgattgcgga tccatcttgc cgagtccggt
718561 cgccgggtgc ggatcaacga cctgtggatc gcggccgtcg cggcatcgcg agcgctgccg
718621 gtcatcaccc aggacgacga cttcgccgcc ctcgacggtg cggccagtgt ggagatcatt
718681 cgggtctgac tcggtggcca cgcgtctctc gcgctgttgt ccgcacccgc agggcgtccc
718741 ggtgggtcaa cgcggcggcc tcagtcgacg aacagcgcca tcgacgcggt aaacccgtgc
718801 aacgcgttgt ggcccgcgac cgggccgatc tccccggcgg cgaagaaacc ggccagcgga
718861 atcccgccca gcaggtcctc gatcgtcgac gcgtcgtggt cggtgacccc gaacattcgt
718921 cgtccgcgcc cgttgcaggt gaacagcagc ccaccgaccg ggggcccggg cagctccgcc
718981 gccgcccgct cgacggccag gcgcaggtcc ttgtcggccg ccgccgcgtc ccggacctgg
719041 aattgcacgg tcgcgccgac ctcgacaacc tcgccgatcc cgatcgcccc cgtcgttggg
719101 tcggcgccga gcagcccgcg gatcaaaaag tcgccctgac ccggcaccgc caggtgctcg
719161 tcgacgacga ttccgatctg caggccgcgg ctgaccagtt cctgctcgtc gggcgccatc
719221 cccaagacga tctcccgcag gcggtgcagc ggcggtcggc cgcccagctc ggtgatcacg
719281 gcaccgtccg cgccggtgac aatgtacggt tccccgatcg gccggcagcc ctgcgacacc
719341 acggaaacgc tgtgcgcgcc gggcaggcgc acgccgacca gcccggaggt gagcacgtcg
719401 cggtcacgaa acagccgggt gtcgccccgc cgacgcccac cgctcaccac cccgccgacg
719461 acggtcgttc ccggcaggtc ggtgttgagg tgctcgatga gcagattcga cgggaacgag
719521 tacgggtccg gcagcagcag gtgcaagtcg tgcgcggtcc ggtcgaagcg gtaaccggtg
719581 atcagagcgc ccgagccggt gcgaacgaag tccaggtgga atgtctccgc gggtgggccg
719641 gacgccagcc acaccgccac cgcgggctcg ttctccagct cgtggcgacc ggcgacgatg
719701 ccttgggcca cgcaaccgat cagcgcggcc ggctcgaccg acgcctgcac cgcagccagc
719761 aggtccacgg cctggtcggt gtgtgaccgc gatccgagga gcacggccag cgccggcgtc
719821 ccacccgcga gctcctcgcg cgcgtgcgcg gcagcctccg ccgcggcccg gcgcacgtcc
719881 ggcgcggtgg aaaccccgac tccgatccgc acacatccat gatgcgccgt cgccgtgctg
719941 ttcgtgtatg cgatgtcaaa gtccgggcgc ggttacccga cgagccgagc acatccccga
720001 cgagtcagcc acaccccgtc gactgtaacc gcatccgcaa cccgctggcc cgcaccgccc
720061 ggcgtgcgat cgcggcccgc accgaagctt cggacccgac cacccggacc ttgcgtttgg
720121 cccgggtcac cgcggtgtac agcaactccc gggtcagcaa ccgcgaatcc tcttgcggca
720181 tcagcaccgt cacctcgtcg acctggctgc cctgactctt gtggatggtc atcgcgtgca
720241 tggtctcgac gtcgccgagg cggccggtgg caacgtcaag tggcccggat gcaccagaaa
720301 tgacggcccg cagaccggtg gggccggcca gcacgacacc ggtgtcgccg ttgtagacgc
720361 gaaggccgta gtcgttggcc gtcaccagca gcggacgccc ggcgtaccac ggcgtccagg
720421 gcggctggcc ggtctcctcg gcgagccagg cttgaacccg gcggttccag tgcagcacgc
720481 cggtgggccc gtcccgatgc gcacacagca gccggtgctc gtccagggtg gccaacgcga
720541 cgtcggaggc acccaacagc gccgcctcgc gcagccgcaa cgcgtgtggc accagcaccg
720601 cgcgcaaccg cggcgccgga tcctcgtcgt cgacgaactc gatccgctcc tcacccgagc
720661 gcagcaggcc cagtacggca tcgccatcgc cggcccggat cgcttcggcc aaggtaccga
720721 tcaccttgcc gaaccgatgc gacgttcgca gctgcgccac cagcgcgtcg tcgcgtaccg
720781 agaagccatc gaccaaatcc gccagcaccg ctccggcttc caccgacgcc aactggtcgg
720841 catcgccgac gaggatcaac cgggcgcccg ggcgcaccgc ctcggccagc cgggccatca
720901 gcgtcagcga caccatcgag gtctcgtcga ccacgatcac gttgtgaggc aaccggttct
720961 ggcgatcctg gcgaaaccgc gctcccggtt tggcacccag cagacgatgc agcgtgaccg
721021 cgtgcaggtc gccgagccgt gcccggtcgg tggcgtcgag cttggccatc tcgcgccgta
721081 ccgcctcggc cagccgggcc gccgccttgc cggtgggtgc ggccagcgcg atccgcggcc
721141 gcggctcacc ggccagctcc gcctgctcgg caaccaacgc cagcagccgc gcgaccgtcg
721201 tcgtcttccc ggtgccaggc ccgccagtca acaccgtaac accttgcgag agcgcgattt
721261 ccgccgcgcg ccgctgctcg tcaaagccgg tcgggaacag tcgccgcaag tcgggtaccc
721321 cggccggtcg cctggatgtc agcaacgcga gcaggtccgc gcacacctgc tcttcttcgc
721381 gccagtagcg gtccagatag agcagccgat cgtcatacag gtgcagcacg ggtggatcgg
721441 cgagcaacgg actggcccgc accgccgcca accagtccgc cggatccggc cacggcaggt
721501 cgtcgtgtcc agcaacccgc gcgatcgaca acagatccac acacaccgaa ccggcccgta
721561 gcgcgcggac cgccaccgct accgccaacg ccacccgctc gtcgctctcc ccggccagtg
721621 cacagagacg ttgcgccaca tgcacatccg acacgtccag cacaccggcc tggttgaagg
721681 cccgcaccat cccggaggcc tcgacggcaa aatcgacgtc ggtgagcttc acgactgcag
721741 ccttccccgg tcgagcagat ccgagagcgc caccaccaac gccgtgggcg ggttccaggt
721801 gaacacaccg gccggatgcc cggccgtcac cggcgtcgcc gcaccgcaca tgccccgcac
721861 aaacaggtac agcaccccgc cgagatggcg cgccggagcg taatcccgct gccgccaccg
721921 cagaaagcgg tgcagcacaa caacatacag cagcgcctgc agtgggtagt ccgaatgcag
721981 catggcctcg gtcaaccgct cgaagccgta atcggcggcg gtgtcaccaa ggtgattggt
722041 cttgtaatcg accaccagat atcgctgccc gggtagccgc agcaccacgt cgatcgaccc
722101 cgccaggtag ccacgcagcg gttgatcacc caacccggcc gaaccaagcc gatcggcgta
722161 gggcgacaac gggtcgtcgc cgggcaggtg cgacgccagc agctcaccca cgtcggccag
722221 cgacacgtcc ggggaccggc cgcgcagatc gcccccggcc agcggcatct cgaagtccaa
722281 ctcccgcaga cgatcacgca caccgatctg ccgcaatgtc agtgcggcgg cggcgggtcc
722341 cagcggcgtg tcgtgcatcg gcagcaacgc tcgggccagt tcgggagcca gctgcgcgtg
722401 gtcgacgtcc acggtccacc acggcgcgtg ccggcgcacc tgggcttcca gttcggcagc
722461 cagatcggga gcggctgggt ccgcggtctc gagcaccgcg tgcaccagcg agccgaacga
722521 cgcccccgac ggcagcgcgg ccagcggtga tgtcagatcg gcgccggaac cgggcgcggc
722581 gacgacggcg atctccacct cgtccgcacg gccgccggcc gccggctcgc tggtgacggt
722641 gacggcttcc gagccccgca ccagatccga gtacgaggtc cgccgccacg tggtgtcgat
722701 ccggcggtga aagtgccgaa cctcgaaacc gggtacgggc accggctttt cgagggaact
722761 gcgagcaccg atgaccgatt cctcgaccga cggcccgccc gcggcctccc actgcgcgaa
722821 caccgcccag gcctgctcgt cggtgacgcg tggtgtacac cggtccggta cctgcgactg
722881 gccgggccgg cgcccgcgca gcaaccgcga caacccgccg ttgacctcgt cgaacgtcgg
722941 tgcccaccac gcgacgacct gcgattgcgc gcgggtaagc gcgacatagg tgagccggag
723001 gttgtcgtgg gccgcctcga cgcggttcag cccctcaacg gtgcgccgct gagcaccgcc
723061 gtccttgccg ccgatgtaca ggcagcgggt gccgtcgtcg tgatacagca ggatgtcgtc
723121 gctgcggacg ttgcggttga aggcgaacgg cagatacacg atgggaaact gcagtccctt
723181 ggccacgaag acggtcatga tctgcaccgc cgcggcgtcg ctgtccaacc ggcgattgtg
723241 ttccggcggg ccggcacccg ccttggcctg gcggcgcagc caatcgcgca gcccgggcag
723301 gccgagccgc tcgcgatgag cggcctcgtg cagcagctgc gcaatgtgcg ccaggtctgt
723361 caggtcccgt tcgccgccgc gctggctcag cacgcgccgg cccatcccgg ccagctgagc
723421 ggcctgaaac accgcggcca caccgcgatg gcgtgcgtgg tcggcccact cgcgcaacgt
723481 gccggccacc cgatcggtca gcgcatcgcc ctcggcggca agcgattccg cggtctcacc
723541 gaagaacatc gtgcacgcgg cggcgcggac cagcccgctg cgctgcggcg cgtcgaacgc
723601 ctccagcagg cacagccagt ccttggcggc ctgcgaggcg aacacgtcgg tgtcaccggt
723661 gtagatcgcc gggatgcccg cctccgccaa cgcattccgg cacgcccgcg cgtctttgtg
723721 atgctcgacg atcaccgcga tgtctgcggc caccacgggc cgcccggcga aggtggcccc
723781 gctggccagt agcgccgcga cgtcggcggc caggtcgtcg gggatgtgcc ggcgcagcgc
723841 ctcgatcggg acgtgggcgg tcccgtcata cccgagcgtg tgccgtttga ccacgcgcaa
723901 ccgaaacggc gccgggcgcg gcgccgaggc caggcggtgc ccggcgtggt gggcgtcggt
723961 gccgcggacg acgatgtcgg cgtgacccag ggtcgcatcg cgcagcaccg tctgcaggct
724021 ctcgaccagc gcccggtcgc tgcgccagtt gacgcccaac gtgtagcggg catcggcggt
724081 gccggccgcc ttgaggtagg tgtggatgtc gccgccgcga aagccgtaga tcgcctgctt
724141 gggatcgccg atcaggatca gcgccgaatg ccggctaaac gcgcgctcga gcacccgcca
724201 ctgcatgggg tcggtatctt gaaactcgtc caccagcacg atccgccagc gttcccgcat
724261 ccgatcgcga gctggcgagt cggccgcctc gagggctgtc gccaaacgga tcagcagatc
724321 gttgaatcct tgcgcacgca gccggccctt gcggcgctcg agttcctcga gcacctcggc
724381 ggcaaagcgc agccgcaccg ctgccttgct gccgggctcg ggatcaggcg ggcgcagttg
724441 ggcgcacggg tcgtcgacga cggcaagggc cagggccagc gcctcggcgt aggtcagctc
724501 cggatcggtc tcctgacgac cgaagttcgc cagatagcga tcgtccacga tctcagtgac
724561 caggtcggta aggctctcct tgagctccac gtcggcggcg ttgtcaccgg ccacaccgag
724621 ggatttcaac accgagccgc agaactcgtg ggtggtggcg atggttgccg cgtcgaagtt
724681 ggccagcgcg tcacgcagcc gcgaccgctt ctgggcgcgc tcggcgtcgc tgccgcgcag
724741 caggtgctcg acgagctcgc cgctcggcgg cgcgtcgcct tgtagcgcgc ccacggcctc
724801 gacgatctgc ccgcgcactc gctcgcgtaa ctcccggctg gccgcacggt tgaacgtgat
724861 caacaacatc tcgtcgagcg tcgcggcggt ttcggccaga tagcgggtga ccagaccggc
724921 cagcgcgaac gtcttaccgg tgccggcgct ggcttccagc acggtggtgg tgccctccct
724981 cggcaacggg cccagcagct cgaagcggtc catcagaccg acccttcggc ggccaacagc
725041 ggcagccata gccgggcggc cagcgcccct agccgggtct cttccccggc gacctcttcg
725101 cccgcgcggg gcttgccgag caacacctcg aagggtgcgc gcgggcccca ggctcgcacg
725161 tgggcgggcg cgtcgtcgtc gcccggccgg aacctgttgg tctgccagca ttcgcgggcg
725221 ggcgggtagg ggtcttggcc gtctcggcgt gcctgggccc acgcgcagga cgtcttcagc
725281 ggcagcggca gtggttcgcg ccggccggcg tcgtacagca acaccagctc ccgcaatacc
725341 gccaccgggt ccggcggcgg cacgaaaagc cttctggcga tgtggttcct ggtcttgctg
725401 cggccgatgc acagcgccga ccactcgcgg ccaggctctt gggcggccag cgtaaccagg
725461 ccgatccacg ccggcaacac atgcttgggc gccagctttg agtaggtcac cgacaccgtg
725521 cgcccgccga acacgggtgt caccgtgccg ctcagtcgcc gcccgtcgcc gaggtcgacg
725581 tcgacgtcgt gcgcctggcc gtggccgtcg cggtgcgcca gcgcggcggc cgccagatcg
725641 cgcgcgcggt tccggatttc cttcgcccgt cgcacgccga ggcgcccggg cggcaacgtg
725701 ccgcgacgcc attcggagtg agcggcgtcg tcggggtgca ggccgcggag catgtcgcgc
725761 aacatccgct cgcccaccgt ccactcggcc aaggcgtcga cctggaccgg tatcgagtcc
725821 tcgacggtgt cgacgtccca gggcagcgtg tagtccagcg cccggaagaa ccccttgacc
725881 ggatccttga agaagtcgag caggtccgcc agcgtcacgt cggccgcggg tggtgcgggc
725941 agccgaccgg agatgaaagc cgttggtgga cagcgcttcc cggcggcggc ctgggcggcg
726001 gcgagcgcgg cggggtcgaa cgtgaacggc ttggcgccca gcagtgcgcc gggggtgacg
726061 ttcttccggt cgaacggctg cagtgggtgt gtgaccagga tccgctcacg caccggcgct
726121 gacgtcgtct ggtcgagcgc gtcgagcaac tcggccagcg gcaccgcggg tgggcgcggt
726181 tgcccggtgc gctcgtcggc gccggtgtaa gtgatcacca gggtctgggt ggccgcacct
726241 atcgcgtcca gcagcaattg ccggtcctcc gaacggatgt cacgttcacc cgtcatcggt
726301 tctcgggcca gcacgtcgtc cccgtcggga tggctcagcc gcggaaacac gccgtcgtcc
726361 agacccacca ggcacaccac ccggtgcggc accgagcgca tcgggaccat cgtgcagacg
726421 gtcagcgtgc cggtgcgaaa gttggcccgg gtcgggcgcc cggccagctg cgcgtccaaa
726481 agcgctcgca cgtcgggcag ccgcaacagc ggcgccgcgc gcgaaccggc gcgcgccagc
726541 acgtcggcga actcccgctg cacctgcgcg cgttgccagc cgtcgttaca ggcggtcagc
726601 agatcgatcc ccgtggccag cgcatccagc catgcgacca acggccgtgc accgctgagt
726661 ccgccgacga catgatgcaa ccgttcgacg aactcggcca gcctcccggc cagctcgacc
726721 cgattgctgc cgacgtcatc aaggggcagc gcggtatcca gccacgcttg ggaatcctcg
726781 gacatggcca ccccggtgag gatgcggtcg agtccgaacc gccacgtgtt gtgcacgacg
726841 gtgtcgaggc catagcgtcg ccggtgcgtc gggtcgaagc cccagcggat gttcgattcg
726901 cgcacccacg tggtgatggt gtccaggtcg tcgtcggcga acccgaattt ggcgcgcacc
726961 ggagcggcct gcgcgaggtt gagcagttgg ctggcggtgg cccgggtttc ggcgatggtg
727021 agcagttcgg cggccaccga gagcagcgga ttggtctggg tcagggcgcg gtcggccaga
727081 cgcacccgca gccggtgtgc ggggtggcag tcgccggcca cctcaccgag gccgaagccg
727141 gcgacgatca acggtgcgta ggtgtcgatg tcggggcaca tcaccacgat gtcgcgcggt
727201 tgcagcgtcg ggtcgtcctc gaggaggccg agcagcacct cgcgcagcac atcgatttgc
727261 cgcgccgggc cgtgacaggc atggacctgc accgatcggt cggcatccga caagctacgc
727321 ccggcgggtc gcggcgcgtt gccggcgatg tcggcttgca gccatcccag caacgtgtcg
727381 ggtttggttg tggcaccaag gaattcgtcg gtggcccggg cggcgggcag cgcgcgctgc
727441 agttcgcgca cgtcgcggcc cagcgtttcc agcagcgggt gctgggcggc ccgccggctg
727501 gtgtcctgcc gccgcggcag caggccatca gcgccctgga agccggccag cgcccgccac
727561 aactcgtcgc tggggtgcgg cagccacagg tgcaggtcgt ggtggacggc cagcgcatcc
727621 agcagctgca cgtcggtgca ggccaggcgg gtgtggccga acagcgaaag ccgagccggc
727681 aggtcggcgg ggccgtcgcg cagccgggcg atggtcttgt cgtggcggac atgcggggga
727741 tcggccccga ccgtggtcac cagggcgcgc cacagtggcg gttgccaggc caagtcgccg
727801 ggcagctcgc cgaggtcgcc gtccagccaa gcggccagca acccgggacg ctggcgtgca
727861 taggacgcga acagcccggc tagccggcgc gccaccgaat agcgccggcc gcggcgcagc
727921 tccgcctcgg catcggtcgt cgcgaagtgc cccaagtggg atgccagcgt gcggcaccac
727981 ggttcgtcga ggctggcgtc gatcaccgcc agcagcggcc acgccagggc ttccggcgac
728041 cacgggtcgt cgtcgagggt gccggtgatc tcggcgatca gggactgcgg attgcggaac
728101 gcgatgccgg cgcacacccc gtcggcgcgg cccggcccgc agcccaacac gagcgaaagc
728161 cgttggctca gccagcgttc cacgccgcgg gcagcgacca gcaccagttc ctgcgcgaaa
728221 gggtcgggct ggggatcggc cagcagcgcg ccgagcccgt cggcaagcag atcggtgcgc
728281 tcggcacggt gcaggtgaag cgccatcggg cgtcacccta gtcgagcggc cggccgccga
728341 catgcatgct ggcgtgcata aacagacgcg agatcaccga acgacaaggg ctaccagtcg
728401 gtacgggcct tcttgtcgac ctggaactgg gtcagatatc gaaccgttcc gggatttcat
728461 caacgcgctg gggcgtgccg cgatgtcggc atgacgagcc gcctcggacg tgacacactt
728521 cgagatggag gaggcggtgt aggtgtgagg cggttgccca aagcaaccgc gtcacccacc
728581 acttacagcc cgaactcggc tgctatcccg tcgatcccgg cccgaatcgc agtgagcgcg
728641 tcggcgcggg agcgcaactt ggtcgcggca tgggcgtgtt ggttgagacc ggcgaactct
728701 cgtgcggctt cctcggcgcg gctgaccacc acctccggca gggcgatctc gtcgataaac
728761 ccggcggcca gcgcggtttc cccgaagaac gtcttggcca gcccggttgc ctgctggtat
728821 gccgaccggg tcagtcgcag cttcatgatc tctaacgccg cgtacggaat ggtcatgccg
728881 atcgcgacct cattggcctg gatgttgtat gcgtgggccg ccacccgatg atcgccgcag
728941 gacaacagaa acgcgcccat ggcgatggcg tgaccggtgc acgccatcac caccggtttg
729001 gggtaggaca agaggcgata cgccagctcg aagccgcccc tgagcatgtc gatcgcgggc
729061 tgcacttcac cggaggtgag gatcttcagg tcgaagcctc cgctgaatac ccggccatta
729121 ccggtgatca ccagcgcccc aacatcatca cggtccgcgt tgtcgatcgc tgcattgagg
729181 gcttgttgca tcgccgggcc cagtgcgttg accttgccgt cgtccatact gatgacggcg
729241 atggaatcct tgcgggtata gctgaccggg tcgctcatgc tctcgattga atcagatcag
729301 cattggggga tcttgtgcgc ccgcagttag cctgccggta tccgcgtggg ctgtggccct
729361 tgcccctccg agcgctggct gacctcggtg ggcacctcga cctgccgagc gcgccacctg
729421 tcctgggttt cggccgcggc gcggttgatc cggtcgatct cgctgcggaa cacgtcggga
729481 cgcgtctcct tgctcgcgta gtgaaaatac gtcaacagac tacgtaacag ctccagcttc
729541 tgcttttccc gcttcgccag gtcgtgggtg gtcatcagct cgatgcgcgc aacgggcggc
729601 agggcatccc agtccagcac cactttggtc tccaacggac gccgtccgcg ccgccagaac
729661 cgccatcggc gcggctgctc gggtcggtcg tagtaggtca ccgtgcccgg gaagcgagac
729721 tcgatgcccc gcccgatctc ggcgcgatcg agcgctgaat cccacaccat ccgccactcc
729781 tgaccgggag ccagcatcgg caactcttgg ggcagccgaa gttccacgac atcggcgtag
729841 ccgttggcgg cattctcgta ttgggccacg gttggtgggt tggggaacga gaaccggacg
729901 tcgtaggcgg ctgtgcgacc gaagttgcgg actaccagct cgatcacgtg ccagtccgcg
729961 acgtggggct ccataaacat ggccacgtag ggccgagtct gctccgcagc cagtcgacga
730021 ttgcgttgga tttgccgctt ggtcaccacc agggcgacca caccgagccc aagcgccgcc
730081 cacgcggccc acgccaacca ggtgccggag tcgacgccgg tgacctcatg ccagctgctc
730141 aggacccacc ccatggaatc caccatccgc ttataccaca gtgacatcgg accgagaagt
730201 tagctgacag gatcccagag gcgcctgggc actggtcgct ggctgccgaa tcgttggcgg
730261 aagcgccgct ggacacgtcg ctggacccgg gccggaacgg gagaggcttg cccagtcctt
730321 cagccgccca tcaacattcg ccattgatcg agacttgcgg ggcgataaac gtaattggaa
730381 cgcttgacct ccgacagcga cgcacttggc tcggccgaat accagtgccc gggaaagacg
730441 gttgggtcac ccggaagctc ggcgagctgt cgcaggctgc ggtacatctc gtcggaatca
730501 ccgccgggaa agtctgtgcg tccacagcct tccaggaata gcgtgtcacc ggcgaccagc
730561 cggccgtcga gtagaaagca ctgactgcct ggggtatgcc cgggtgtgtg cagcagctcg
730621 atgtcgatgt cgccgacgct gaccttgtcc ccatgctcat gggtgatcag gtcgccgaca
730681 ggaatcccag tgactcgcga aacccacagc gcttcatggg tgttcacgtg cacgggtaca
730741 gatgcccgct ccagcagctc agccagtccc ggcagctgaa aacccatcat cgagccgccc
730801 acatggtctg gatgatggtg ggtcaccagc acacccgata gctgcatatc gtcggattcg
730861 agcgcgtcga gcagatcccc ggcagcgtag gccgggtcga ccaccacgca gtccccggtt
730921 gtgcgatctc cgatcaggta ggcaaagttg cgcatttgcg tcgcgaacat gtcgccgacg
730981 gcgaaatcgc gaccggagag cagttgacgg aagtacagcc ggtccttgga cacgcaacca
731041 gcctatgtct tgtccatcgc cgcccagacc gcgtcttggc gtttgcagcc cgggacacgt
731101 taatgcggag tcttggggtc tgactgtggg tgcggtgggt atctttggtc catgctgaag
731161 agggtcgaga tagaggttga tgacgacctt atccaaaagg tcatccggcg gtaccgtgtg
731221 aagggtgcgc gcgaggctgt caaccttgcg ctgcgaacgt tgctcggcga ggcggatacc
731281 gcggagcatg ggcacgatga cgagtacgac gagttcagcg atcccaatgc ctgggttccg
731341 cggcggagcc gcgacacagg gtgatcccgt ccaatcttgg acgacttggt ccgtagctgc
731401 atgggtggca ccggtggttt ggtggcgttg cgcgccaggc tgtaccctct tttaggcccg
731461 cggcacgacc cgactggtcg ctacgggtga gcggccccct tagctcagtc ggcagagcgt
731521 ttccatggta aggaaaaggt caacggttcg attccgttag ggggctcggc ggacgccggg
731581 caggctggcg gtgcgtacca gaggcgatgt agctcagtcg gttagagcga acgactcata
731641 atcgttaggt cgccggttcg agtccggcca tcgctacaac acaacagcaa gactcgttag
731701 agagaacgga tatggcttcc agtaccgacg tgcggccgaa gatcactttg gcatgcgagg
731761 tgtgcaagca ccgtaactac atcaccaaaa agaaccgccg caacgacccg gaccggctgg
731821 agctgaagaa gttctgcccg aattgcggca aacaccaggc gcaccgcgag acgcggtaac
731881 cgccgacccg cgagcagttg ctgagactga ctaggtaggt tctacagccg tggcgttgag
731941 cgcagacatc gttgggatgc attaccggta tcccgaccac tacgaggtgg agcgggagaa
732001 gattcgcgag tacgccgtcg ccgttcaaaa cgacgacgcg tggtatttcg aggaggacgg
732061 cgccgccgaa ctcgggtata agggcttgct ggctccgttg acgtttatct gtgtgttcgg
732121 ctacaaggcc caggcggcgt tcttcaagca tgcgaacatc gcgaccgcgg aggcgcagat
732181 cgtccaggta gaccaagtgc tgaaattcga gaaaccgatc gtggcgggcg acaagctgta
732241 ctgcgacgtc tatgtggatt cggtgcgtga ggcgcacggc acccagatca tcgtgaccaa
732301 gaacatcgtc accaacgagg aaggtgacct cgtgcaggag acctatacga ccctggcggg
732361 ccgtgccggc gaggatggag agggattttc tgatggcgct gcgtgagttc agctcggtga
732421 aggtcggaga ccagcttccg gagaagacct acccgctgac ccgccaggat ctggtgaact
732481 acgccggagt ttcgggtgac ttgaacccga ttcactggga cgacgagatc gccaaggtcg
732541 tcgggctgga caccgcgatc gctcacggca tgttgacgat ggggatcggc ggtggctacg
732601 tcacatcctg ggttggcgac ccgggcgcgg tcaccgagta caacgtgcgg ttcactgcgg
732661 tggttccggt gcccaatgac ggcaagggcg ccgagctggt gttcaacggt cgggtgaaat
732721 cggttgatcc tgagagcaag tcggtgacca tcgcactcac cgctactacc ggcggcaaga
732781 agattttcgg gcgggccatc gcctcggcga agttagcgta gtttatggcg ctcaagaccg
732841 atatccgcgg gatgatttgg cggtacccgg actacttcat cgtgggccgt gagcaatgcc
732901 gcgagtttgc ccgagctgtc aagtgcgacc acccggcctt tttcagcgag gaagcggccg
732961 ccgacctcgg ttacgacgcg ctggttgctc cgctgacctt cgtgacgatc ctcgccaaat
733021 atgtgcaact ggacttcttc cgccacgtcg acgtgggcat ggagacgatg cagatcgttc
733081 aggtcgacca gcggttcgtg ttccacaaac ccgtgctcgc cggggacaag ttgtgggctc
733141 ggatggacat ccattcggtg gacgagcggt tcggcgcaga catcgtcgtt accagaaacc
733201 tctgcaccaa cgacgacggt gagctggtca tggaggccta caccacgctg atgggccagc
733261 agggtgatgg ttccgccaga ctcaaatggg acaaggaatc cgggcaggtc atcaggaccg
733321 cgtaattagc aactggccgc tgcggccatg tacactcgga cctcggggtt ttcccaacat
733381 cggcgcgctt tccgtgagtt caacgagcgg agtgtcgtct ccactttcgg ttcgcgatca
733441 ccgaacggag ggcgcgcgtg tcatgtgagc cccggcgtag tgggttggcc agggcctggt
733501 ctggtcttgc ctgccaaccg cgaaggggcg tagctcaact ggcagagcag cggtctccaa
733561 aaccgcaggt tgcaggttca agtcctgtcg cccctgctga aggcgaacgt tcgacgacga
733621 tgcaggcacg gcctgaagag gagacggacc ataggtatgt gccatggtgg acactggaag
733681 gtgccccacc agagcggaac ggctcgcggg gtagctagta aacgaaggag catgcggtga
733741 gcgacgaagg cgacgttgcc gacgaggccg tagccgacgg cgccgagaat gcggacagcc
733801 gcgggagcgg tggccggacg gccctggtga caaagccggt ggtgcggccg caacgtccca
733861 ccggcaagcg gtcgcggtcg cgtgcggcag gagccgacgc agacgtcgac gtcgaagagc
733921 cgtcgaccgc ggcttcggaa gctaccgggg tcgccaagga cgattcgacc accaaggccg
733981 tgtcgaaggc tgccagggca aaaaaggcca gtaaaccgaa ggcccggtcg gttaacccga
734041 tcgcattcgt ctacaactac ctcaagcagg tcgttgccga gatgcggaag gtaatctggc
734101 cgaaccgcaa acaaatgctt acctacacgt cggtggtgct ggcgtttctg gccttcatgg
734161 tggcgctggt cgccggtgct gacttgggcc tgaccaagct ggtgatgttg gtgttcggct
734221 gaggctcgag agtgacagag aggactgaaa accgtgacta ccttcgacgg tgacacgtcc
734281 gcgggtgagg cggtcgatct aacagaggcc aacgccttcc aggatgcagc ggccccggct
734341 gaagaggtcg atccggccgc cgcgctcaaa gcggagctgc gcagcaagcc cggcgactgg
734401 tacgtcgttc actcctacgc agggtacgag aacaaggtca aggccaacct ggaaacccgg
734461 gtgcagaacc ttgatgtcgg cgactacatc ttccaggtgg aggtgcccac cgaagaggtc
734521 accgagatca aaaacggcca acgcaagcag gtcaaccgta aggtgctgcc cggctacatt
734581 ctggtgcgga tggacttgac cgacgactcc tgggccgcgg tgcgtaacac gccgggggtc
734641 acggggttcg ttggggcaac atctcgcccg tcagcgctcg ccctcgacga cgtggtgaag
734701 tttctgcttc cgcgggggtc gacgaggaag gctgccaagg gtgcggccag cacggctgcc
734761 gccgccgagg cgggcgggct agagcgtccg gtcgtcgagg tcgactacga ggtgggcgaa
734821 tcggtaaccg tcatggacgg gccgtttgcc acattgccgg ccacgatcag cgaggtcaac
734881 gccgaacagc agaaactcaa ggtgctggtc tccatcttcg gccgcgaaac accggtggag
734941 ctgacctttg gccaagtctc caagatctag cccagcaggg caggccacac aggctgaaac
735001 aaggaaggac atcgacacgt catggccccg aagaagaagg tcgccgggtt gatcaagctg
735061 cagatcgtgg cgggccaggc caaccctgcc ccgccagtgg gccccgcgct cggtcagcac
735121 ggcgtcaaca tcatggagtt ctgcaaggcg tacaacgccg cgacggagaa ccagcgcggc
735181 aacgtcatcc cggtggagat caccgtttat gaagaccgta gcttcacttt cacgctgaag
735241 acgccgcccg ccgccaagct gctgcttaag gccgctggtg tggcgaaggg ttcggcggag
735301 ccgcacaaga ccaaggtcgc caaagtcacc tgggatcaag tccgcgaaat cgccgagacc
735361 aagaagacgg acctcaacgc caacgacgtc gacgctgcgg ccaagatcat cgccggtacc
735421 gctcggtcga tgggcatcac cgtcgaatag ggccctaccc gtgggagggc cagcttcggc
735481 ccgctgagta accacgaccc atagattgga tatcaaatga gcaagaccag caaggcatat
735541 cgcgccgccg ccgcgaaggt ggaccgcacc aacctctaca ccccgctgca ggcggccaag
735601 cttgccaaag agacctcgtc gaccaagcag gacgcgaccg tcgaggtggc gatccggctt
735661 ggcgtcgacc cgcgtaaggc agaccagatg gttcgcggca cggtcaacct gccacacggc
735721 actggtaaga ctgcccgcgt cgcggtattc gcggttggtg aaaaggccga tgctgccgtt
735781 gccgcggggg cggatgttgt cgggagtgac gatctgatcg agaggattca gggcggctgg
735841 ctggaattcg atgccgcgat cgcgacaccg gatcagatgg ccaaagtcgg tcgcatcgct
735901 cgggtgctgg gtccgcgcgg cctgatgccc aacccgaaaa ccggcaccgt caccgccgac
735961 gtcgccaagg ccgtcgcgga catcaagggc ggcaagatca acttccgggt tgacaagcag
736021 gccaacctgc acttcgtcat cgggaaagcg tcgttcgacg agaagttgtt ggcggagaac
736081 tacggcgcgg cgatcgacga ggtgctgcgg ctcaagccgt cctcgtcgaa gggccgctac
736141 ctgaagaaga tcaccgtgtc gacgacgacg ggcccgggca ttccggtcga cccatccatc
736201 acccgcaact tcgcggggga gtagtttccc cggcgagcag acgcataagc ccccgcacgc
736261 acggcgtgtc gggggcttat gcgtctgctc gccgggctta ggccgcggca cccggcttga
736321 ggtaggtcac caggctgcag tcgagcatct cgtcggtgaa gtagtgctcg cagccacgca
736381 aatacttcat gtagcggttg tagacctctt cggaggtgac ctcgatggcc ttgtccttat
736441 tggactgcag cgtgtccccc cagatccgca gcgtcttgat gtaatgcggg cgcaacgaga
736501 gcggctccgg gacggtgaaa ccggccttct cgccgtgttc gaccatcatc tcggtggacg
736561 gcaggcggcc gccgggaaat atctcggtga cgatgaactt gatgaaacgc gccgtctcga
736621 agctcagctt cttaccgcgg gccgccatct cgtaggggtg gtagctgacg ctgctctgga
736681 cggtcatccg gccgtcggcg ggcatgatgt tgaaacaccg cttgaagaag tcgtcgtagt
736741 tctcgtgccc gaagtgctcg aaggcttcga tcgacacaat ccggtcgacg ggttcggcga
736801 aatcctccca gccttgcagc agcacttgac gtgagcggtt ggtgtcgatc gaagccagca
736861 cttgctcgca gcgggcgtgc tggttcttgg acaacgtcag gccgatgacg ttaacgtcga
736921 accgctcgac ggcgcgcctc atggtggtgc cccaaccgca cccaatgtcc agcagcgtca
736981 tgcccggctt gaggtccagc ttgtccaggt tgaggtcgac cttggcgtat tgggcttctt
737041 cgagcgtgag ctccggtggc tcgaagtagg cacagctgta agttcgggtc gggtcctgga
737101 acagggcgaa gaaatcatcg gagacgtcgt agtgcgcttg gatgtcttcg aagcgtgtcc
737161 gtgtcttggt tgggctaatc ggtttctcgg ccattctcgt catgttctcc tggatggtgt
737221 cagttaccgg tggctgtgca cccatagccc gtcggtggca cgaaagtcta cttggccagc
737281 gtgaactggt tgcagtcgat gtagcccatt cggaacgcct tggcgcagcc ggtcaggtat
737341 ttcatgtacc gctcgtatac ctctgcggac tggatctcga tggcctcgtc cttgtgcgct
737401 tgaagcgcct cggcccacag gtcaagagtc ctggcgaagt gcggttgcag ggactggata
737461 tcggtaatgg tgaaaccggc cttcgtcaca tgctcctcga tcgtctcgat cgtcggcaac
737521 cggccgcccg ggaagatgtc ggtcacgatg aaccggatga atttggccat ctccatggtc
737581 aacggtatgc cgcgctcgat gacctgcttt acgtgcaagc cggtgatcga gtgcagcagc
737641 atcacgccgt ccgcgggcat cgcgttgtag gcgaacttga agaagtcatc gtagcgctcg
737701 aaaccgaagt gctctatcgc ttcgatggtt acgatgcggt ccaccggctc gctgaagttg
737761 gcccagtcgc tcagcagtac ccggtgcgag cggttggtgt cgaccttgtc gagcacttgc
737821 tggcagtagg cgtgctgatt tttcgacagg gtcaagccga cgacgttgac gtcgtagcgc
737881 tcgacggcac gcttcatgac cgaaccccag ccgcagccca cgtcgagcag tgtcattccc
737941 ggttctagcc ccagcttgcc cagggttagg tccagcttgg cgacctgtgc ttcgtgcaag
738001 gtcatgtcgt cgcgctcgaa gtaggcgcag ctgtaggtcc gagtcggatc ctggaacagc
738061 gcgaagaacg catctgaaag gtcgtaatgg gcttggacgt cgtcgacatt ggaccgagac
738121 tttgtggtgc ccgttgagtt atcagacatg tgtcctccca ctgtgagggg caccttcagc
738181 aggtggccat ccccggcacc ctacacggtg catggcacat cgcccgcatt cgcgctcgca
738241 tgcgccggtc tttctcgatc gggatttgcc agatatcacc ctggccggcg caatcactac
738301 ttcgccagcg tgaactggtt gacgtcgatg tagccgaccc ggaacagctt ggcgcagccg
738361 gtcaggtatt tcatgtaccg ctcgtagacc tcttcggact ggatcgcgat ggcctcgctt
738421 ttgtgttcct gcagcgcctc ggcccacagg tcgagggtcc tggcgtaatg cggctgcagc
738481 gactggcggc gagtcagcgt gaaacccgtc ttcgccgact gttcctcaac catttcaatc
738541 gtcggaggtt ggccccccgg gaagatttcg gtcgcgatga acttgagaaa gcgggccagc
738601 cacaacgtga gcggcaagcc gtggtcgacc atctgctgcc tggtcaggcc ggtgatcgtg
738661 tgcagcagca acacgccatc gggcggcagg attttgtggg cccgggcgaa gaagtcggcg
738721 tgacgatcgt ggccgaagtg ctcgaacgcg ccgatcgaca cgatgcggtc gacgggctcg
738781 ttgaactgct cccatcccgc cagcaacact cgcctgtcgc gcggggtgtc catctcgtcg
738841 aacgacttct gcacatgggc ggcctggttc ttcgacaatg tcaggccgac gacgttgacg
738901 tcatactgcg cgatcgcgcg ccgcatggtg gcgccccagc cgcaaccgat atcgagcagc
738961 gtcatgccgg gctgcagacc tagcttgccc agcgccaggt cgatcttggc gatctgggcc
739021 tcttccagcg tcatgtcctc gcgttcgaaa tgcgcgcagc tgtaggtctg ggtcggatcc
739081 aggaacagcc ggaagaagtc gtcggacagg tcgtagtgtg cctgcacgtc ctcgaagtgc
739141 ggcgttaggt cgttgaccat gaggtgtaat gcctttccgg accctaggtg gcctttcggt
739201 gcttgcacgg aacgcaccga tgcttccccc tccccgcatg ctcgaggcat gctatccgat
739261 acagggccgc cgcactaaac cgcgatcgaa tttgcccagg tcagggaacg gatatgagcg
739321 gacgagctac ttggtcatgg tgaactgggc gacgttgatt aggcctctgc ggaagcgctc
739381 cgcgcatccg gtcagatagt gcatgaagtt gttgtagacc tcttcggact gtacggcgat
739441 ggcgcgttcg cgggcagcct gtaggttggc ggcccatgca tcgagagtcc gtgcgtagtg
739501 ctgctgcagc agctggacat gctcgatggt gaagcccgcg gcctgcgcat tgtcgacaat
739561 gtcgggctcc gatggcagct cgccgcccgg gaagatcgac tcccgcagga atttgaggaa
739621 tcgaaggtcg ctcatcgtca gcgcaatgcc ctgttcgtgc agccacctgc ggtcgtaggt
739681 gaacaggctg tgcagtagca tccgcccgtc atcgggcagg atgtcgtagg agcgttcgaa
739741 gaacgtcaga taccgctcct ttttgaacgc gtcgaatgcc tcaaagctga cgatccggtc
739801 gacgttctct tcaaactctt cccagccctg cagccgggcc tcggcgcgcc gttgcgttcc
739861 gattgcggcc aggcggtctt tgctgcgttc atagtgattc cggctgagcg tgaggccgat
739921 gacattgacg tcgtacttct ccacggcccg aacgagcgcc ccgccccacc cgcaacccac
739981 gtcgagtagc gtcatccccg gttcgaggtt cagcttgtcc aacgccagat ccaccttggc
740041 cagttgcgcc tcttccagcg tcatatcgtc acgctcgaaa taggcgcagg tgtagaccca
740101 ggtgggatcg aggaacaacg cgaagaagtc atccgaaatg tcgtaagccg actgtgactc
740161 ttcgtaatat ggtctcagct tggccatagg cgacaacctc ccgcgccaac cgtacaacgc
740221 ctcgccgacc ggctcagccg gcctcagaga agttgcgcgt caactcgccg atcacccgat
740281 cccacagctg tctgggcagg tcatggccca tgccgtcgat gagcaccagg cgcgcgccgt
740341 tgattgctcg cgcgaccgcg cggccgccga acggccgcat cagcttgtcc gcgcgcccgt
740401 ggatgacgac ggtcggtgcg acgatgcgcc ggtcgtagcg cagcaggctg ccgctgccca
740461 gtatcgcgct gaactgctgg gcgattcccc agggatggaa gttgcggtcg tagctttcgg
740521 cggcctcggc tcgtacctgg tcttcgggaa tcgggtaggc cgggctgccg atgatcttgc
740581 tgacccggac ggcgttgtcg acaatgacgt cgcgtggcga atccggcggc ggacccgtga
740641 gcagcgccag cagcgcgcgt ggcgccggcg gtggcagaaa ccggtgattg ttgctggaga
740701 agatgaccgc cagggttttc gtccgctgcg cgaatcgcgc ggcgaaaatc tgggcgatca
740761 tgccgcccat cgacgccccg acgacgtgcg cgtgcttgac gtcgaggtga tcgagcaacg
740821 ccgcggcgtc ggcggccatg tcttccaacg tgtaggcagc ctggctgggc agaccgagcc
740881 aggaccggac caaccgcgtg gccagtggct gtcccgggcg gtggcgctcg gtcttggtgg
740941 acaggccgac atcgcggttg tcgtagcgga tgacgcgcag gcccttcgcg acgagccgcg
741001 cgcagaagtc ggtccgccac agcagcatct gggcgcccag gcccatgatc agcaacaccg
741061 gcgggtggtc gaggtcaccc atgtcctcgt agtacagctt cacatcaccg gagaccgcgg
741121 tgccgctacg gatgtccacc gagacctcgc ctaaacctcg atgtcggatt gatgttcgcg
741181 gctgacctcg accatgaagt tggcgaaata tccggtcagc tgcgggtccg acatcatctg
741241 ccacctcggc gccagcagct tcatgtagcg ctccacgtac aggaactgct tgccgatcag
741301 caccagctcg cggggcagct tgacgtcgta ggcgtcggcc agcgccgaga gctggcggcc
741361 gatgtcggca tatgacatgt cgcccagcga ttgcatggtc agcggggtgg cgaagcgctc
741421 caggtctttg gcggcctggg tctcgggctt catggtgccg acggcgccca tgagcacgac
741481 gatcttgccg gcggctgcgt ggtccttctt caccagcagc gcatacacca gctcgcggag
741541 tagccagcgg gtgcgtggat cgatgcggcc catgatcccg aagtcgaaga acacgatgcg
741601 gcccgcctcg tcgacgtaga ggttgcccgc gtgcaggtcg ccgtggaaca gcccgtgccg
741661 caggccgccc tcgaacaccg aaaacagcag tgccttgacc agctcgacac cgtcgaaccc
741721 ggccttgcgg atcgcggcgg cgttgtcgat gcggatgccg tgcacccgtt ccatcgtcaa
741781 cacccgctcg gtggtgaagt cccagtgcac ctgcggcacc cggatgtttt tgcccagcgg
741841 cgaggcgtgt aggtgggaga cccaggcctc catggactgc gcctcgaggc gaaagtccag
741901 ctcctcggcc aggttgtcgg cgaagtcggc gaccacgtct tgtgccgaga gccgccggcc
741961 cagcttggcc agttcgacgg tctgcgcgaa gcgcttgagg atctgcaggt cggcggcaac
742021 gcggcggcgg atgcccggcc gctggatctt gaccaccacc tcctcgccgc tgcgcagggt
742081 cgcgtagtgc acctgggcga tggacgccga cgcgaacggc tcttcctcga aggaggcgaa
742141 cagccgggcc ggctcgtcgc cgagttcctc gacgaagagc ttgtgcacct cgtcggtttt
742201 tgcgggcggc acccggtcga gcaggccgcg gaattcccgc gacagcgact caccgaatgc
742261 tcccgggctg gacgcgatga tctggccgaa cttcacgtat gtcggtccca gatcggcgaa
742321 ggtctgcggg agctccttga tcaccttctg ttgccagggc ccttttcggg ggagcctgcc
742381 gatgaaccgg acggcggtgc gggtgacctg ccaaccggtg gccgccaccc gggcagcttc
742441 gaccggcagc ggtacccggt caagcttggc cacctcgcgg tgtgtggtgg aacccatctg
742501 agcagtgtgc caaaccgggg cagacagctc ccaattgacg tgagcccgct cacttgctgg
742561 gtaagcgtcg ccgaatgtgt aatgagggcg gaaatccggc ccgatttccg ccctcattac
742621 acattcggcg acgcgtggac tacctcaagc cgtactggga tacccacccg caggaccgcg
742681 ccgacctgcg ccggttcctc gccgatggcc gtatcgaagt gatgggcgga acctacaacg
742741 aacccaacac caacctcacc agcccggaga ccaccatccg aaacctggtg cacggcatcg
742801 gttttcagcg tgacgtgctg ggcgccgagc cggccaccgc gtggcagctc gacgtgttcg
742861 gccatgaccc gcaatttcct gggctggccg ccgatgccgg gctgacgtcg agttcctggg
742921 cccgcgggcc acaccaccag tggggtccgg cccaaggcgg ggtagaccgc atgcagtttt
742981 gcagcgagtt cgagtggatc gcgccgtcgg gtcgcggcct gttgacccat tacatgccgg
743041 cgcattattc ggcgggctgg tcgatggact cgtccacctc gctggccgac gctgaggccg
743101 ccacctacgc gctgttcgac cagctcaaaa aggtcgcgct gacccgcaac gtgctcctgc
743161 cggtgggcac cgactacacc ccgccgaaca agtgggtcac cgccatccac cgcgactggg
743221 gtgcgcgcta cacctggccg cgcttcgtgt gcgcgctgcc caaggagttc ttcgccgcgg
743281 tgcgcgccga actggccaag cgtggttggg tgccgtcgcc gcagacccgc gacatgaacc
743341 cgatctacac cggcaaggac gtctcctaca tcgacaccaa acaagccaac cgggccgccg
743401 agaacgccgt cctggaagcc gagcggttcg cggtgttcgc cgcgctgctg accggcgccg
743461 agtatccgca ggcggcgttg gccaaggcgt gggtgcaact ggcctacggt gcgcaccacg
743521 acgccatcac cggctcggag tccgaccagg tctacctcga cctgctgacc gggtggcgtg
743581 acgcgtggga gctgggccgc gcggcccggg acaactcgct gcggttgctg tccggcgcgg
743641 tcgccgcgtc gcacgatcgc gtcgtcgtgt ggaacccgct gacccagcgg cgcaccgaca
743701 tcgtcactgc cagggtcgac ccgccgctgc aggccggcgt gcgggtgttc gatcccgacg
743761 gggctgaggt ggccgcgctc gtcgagcacg acggacggtc ggtcacctgg ctggcgtgcg
743821 acgtgccctc gctgggctgg cgggtttacc ggttggtgcc cgccgacgag gcgccaggct
743881 gggaattggt acccggcacc gacatcgcca acgagcacta tcggctggcc gtcgaccccg
743941 agcgtggcgg ggcgttgtcg tcgctggtgc aggacggccg ccagctgatc gccgccggcc
744001 gggtagccaa cgagctggcc ctctacgagg aatacccgtc gcacccgact cagggggagg
744061 gtccgtggca tctactgccc acggggccgg tggtgtgctc ctcggcatgc ccggcgcagg
744121 tgcaggcata ccgcggcccg ctcggtcagc ggttggtcgt gcgggggcgg atcggcaccc
744181 tgctgcgcta cacgcagaca ctcaccttgt gggacggcgt cgaccgggtg gactgccgca
744241 ccagcatcga cgagttcacc ggggaagacc gcttgctgcg gctgcgctgg ccgtgtccgg
744301 tacccggcgc catgccgatc agcgaagtgg gggacgccgt cgtcgggcgg ggtttcgcgt
744361 tgctgcacga ggggcccgaa tcggtggaca ccgcccagca tccgtggacc ctggacaacc
744421 cggcctacgg ctggttcggg ttgtcctcgg cggtgcgggt acgcgccggc gatggggtgc
744481 gcgcggtgtc ggtggccgag gtggtgtcgc cgacggagac ggtgtccggc ccgatggcgc
744541 gcgacctgat ggtcgcgctg gtccgcgcgg gcgtcaccgc gacctgcagc ggcgccgaca
744601 agccgcgcta cggccacctc gatgtcgatt ccaatctgcc ggacgccagg atcgcgctcg
744661 gtgggccgga ccgcaacacg ttcaccaagg ccgtgctggc cgaggccgcc ccggcctaca
744721 ccgccgaact gcagcggcag ctggcgaaga ccggcacggc cagggtgtgg gtgccggccg
744781 cgaacccgtt ggcgcgggcc tggctgcccg gcgcggactt gcgggcaccg tgcgcgctgc
744841 cggtgctggt gatcgacggc cgagacgaga agcacctgcg cgccgcggtg gcgtcgctgg
744901 ccgacgacct ggccgacgcc gagatcgtcg tgcaccagcg ggccgcgccg caaatggagc
744961 cgttcgagga tcgcacggtc gcgctgctca accgtggggt gcccagcttc gccgtcgact
745021 ccgagggcac cctgcacacc gcgctgatgc ggtcgtgcac cggctggccc tccggggtct
745081 ggatcgacca gccgcgacgc accgccccgg atggctcgaa tttccaactc cagcactgga
745141 cccaccactt cgactacgcg cttgtctgcg gcggcggcga ttggcggcgc gccggcatcc
745201 cggcgcgcag cgcgcagttc tcccacccgc tgcttgcggt ggcgccgcga cggccacagg
745261 gcgagctgcc ggcggtcggc tcgctgctgc acgtcgagcc ggccgactcg gtgcagctgg
745321 gcgcgctcaa ggcggccggc aacccgctgg cagccggcag cgcgcggccg gtccaacccg
745381 ccgcggtggc gctgcgattg gtgcaaacga caggagccga caccccggtc accatcggct
745441 gcgagctggg caaggtaggc gccctccggc cggccgacct gctggaaacg ccgctcgcaa
745501 tggcaagggc gcgcaagtcg tccatcgacc tgcacggcta tcaggtcgcc accgtgctgg
745561 cccggctcga cgtggccgct gatatggcta acgtgctggc ggccgacgac gtggcgttgg
745621 cgccgcacgc cgagaccgct cagccgcagt acgcgcgcta ttggctgcac aaccgcggcc
745681 cggcgccgct gggcgggctg cccgcggtcg cccacctgca cccgcggcgg gtgcgcggcc
745741 agcccggtga cgacgtggtg ctgcgcctga ccgcggccag cgactgcacc gattcggtgc
745801 tgggcggcgt ggtcgacgtc gtgtgtccgc tcggctggcc ggccacaccg gctcggttgc
745861 cgttcacgct gggcgccggg gcgcacctgc aggccgacat cgcgttgagc attcccgccg
745921 gcgcgccgcc gggaccgtat ccggtccgcg cgcagctgcg cgtcgtcgac acggcggtac
745981 cggccgcctg gcgccaggtg gtcgaggacg tgtgcgtggt caccgtcggc gccgactccg
746041 atctggagga gctggtctac ctcgtcgatg ggccggccga catcgagctg gccgccggcg
746101 accgggcccg gctggcggtg acgatcggca gccgcgctca cgccgagctg gccctggatg
746161 cgcactcgat cagcccctgg ggcacctggg agtggatcgg cccgcccgcg ctcggcgccg
746221 tgctacccgc ccggggcatg gccaagctgg ctttcgatgt gaccccgccg gcctggctgg
746281 agcccgggca gtggtgggcc ctggttcggg tcggttgcgc gggtcagttg gtctattcgc
746341 cggcggtgaa ggtgagcgtg acatgagcgg gcgaagccga ttgcccggct cctcctcacg
746401 ccgcgacgcg gcgcgcatcg tcgccgagcg ggtggtcgcg accgtcgccg gtgtcgcggt
746461 agcggtcgac gaggtcgacg cggccgaagc gcggctgcgc gacggaccgc gcgcggccgc
746521 gctgccggcg agcggcacca gcgagggacg ccaactgcgg cgctggctca cccaactgat
746581 cgtgaccgag cgggtggtag ccgccgaggc cgccgcacgt ggtctgaccg cggcgggcgc
746641 ccccgccgag gcggacctgc tgcccgacgc gacggctcgg ctggagatcg gcagcgtcgc
746701 cgccgcggtg ctggcggatc ctttggcgcg ggcgttgttc gccgccgtca ccgcgcgggt
746761 cgcggtcacc gacgacgccg tggccgacta ccatgcccgc aacccgctgc ggttcgccgc
746821 gccatgtccc ggccagcacg gctggcgtgc cccggcggcg gccgccccac cgctggatca
746881 ggtgcgccgc gcgatcaccg agcatctgtt gggggccgcg cgccgccgcg ccttccgggt
746941 gtggctggac gcgcgccgga acgccctggt ggtgctggcc cccggctatg agcaccccgg
747001 cgacccgcgc caacccgaca acacccgccg gcactgatgc tcaccctttg cctcgacatc
747061 ggcggcacca agatcgccgc gggcctggcc gacccggccg gcacgttggt gcacaccgcc
747121 caacgtccca ccccggcgta tggcggagcc gaacaggtct gggccgcggt cgccgagatg
747181 atcgccgacg cgctcggcgt ggcggggggc gcggtcggtg gtgtggggat cgcctcggcc
747241 ggtcctatcg acctacacag cggccgcgtc agcccgatca acatcggatc ctggggcggc
747301 tttccgctgc gggatcgggt cgccgccgcg gtcccggggg ttccggtgcg gctggggggt
747361 gacggggtgt gcatggcgct cggcgagcac tggctgggag ccggacgggg tgcgcgcttt
747421 ctgttgggtt tggtggtgtc caccggggtg ggcggcgggt tggtgctcga cggcgccccc
747481 tgtctcggcc gcaccggcaa cgccggtcac gtcggccacg tggtggtgga tccggatggc
747541 tcgccgtgcc cgtgcggggg gcgtggctgt gtggagacca tcgcgtccgg cccgtcgctg
747601 gcgcgctggg cgcgggccaa cggctggtcc gcgccgcccg gggccggcgc caaagagctg
747661 gccgaggcgg ctggggccgg agacccggtg gcgctgcggg ccttccgccg cggcgccgcg
747721 gcgctggccg cgatgatcgc ctcggtgggc gccgtgtgcg acttggatct cgccgtcatc
747781 ggcggcggcg tggccaagtc gggtcgcctg ctgttcgagc cgttacgtgc ggcgctagcc
747841 gaccacgccc ggctggactt tctggccggc ctgcgggtgg tgcctgccga gctgggcggc
747901 gccgccggcc tggtgggtgc ggccaggctc gcggccatcg cataatgccg attgtgaatc
747961 tggcgacgcg acacgccggt gcggcgtcgc gggattcaca ctcggcgata cgtgtcgccg
748021 ttttggctga ccggaccggg ccaggctatt gtggttgccg atccaccgaa gaccgtcggt
748081 caccgagcaa tcggttgaag gtccgggagc atcccggcga cccacgcagg aggacgaggc
748141 agcaccgccg gcgcgcgccg gcctagttcc acgccccgac cgcttcctgc gtcggggcgt
748201 tcgtcgttcc cgggtggtcg cagacggcac gtcgtacccc gactgccacc agacttgcac
748261 cgtcaggagg tatgcatggc cagggctgac aaggccaccg ccgtcgcaga catcgcagcg
748321 cagttcaagg agtcgaccgc gacgttgatc accgaatacc gcggcttgac ggtggccaac
748381 ctggccgagc tacgcaggtc tctgacgggg tcggcgacct acgcggtggc caaaaacaca
748441 ctcatcaagc gggcggcctc cgaggccggc atcgagggcc tcgacgaact gtttgtgggc
748501 cccaccgcga tcgcgttcgt caccggtgag ccggtcgacg ccgccaaggc catcaagacc
748561 ttcgccaagg agcacaaggc gctggtcatc aagggcggct acatggacgg ccacccattg
748621 accgtggccg aagtcgagcg catcgccgac ctggagtccc gcgaggtgtt actggccaag
748681 ctggccggtg cgatgaaggg caacctggcc aaggcggccg ggttgttcaa cgcgccggcc
748741 tcgcagctgg cccggctcgc ggccgccctg caggaaaaga aggcctgccc aggcccagac
748801 tcagccgagt agtcacccag taccccacac caggaaggac cgcccatcat ggcaaagctc
748861 tccaccgacg aactgctgga cgcgttcaag gaaatgaccc tgttggagct ctccgacttc
748921 gtcaagaagt tcgaggagac cttcgaggtc accgccgccg ctccagtcgc cgtcgccgcc
748981 gccggtgccg ccccggccgg tgccgccgtc gaggctgccg aggagcagtc cgagttcgac
749041 gtgatccttg aggccgccgg cgacaagaag atcggcgtca tcaaggtggt ccgggagatc
749101 gtttccggcc tgggcctcaa ggaggccaag gacctggtcg acggcgcgcc caagccgctg
749161 ctggagaagg tcgccaagga ggccgccgac gaggccaagg ccaagctgga ggccgccggc
749221 gccaccgtca ccgtcaagta gctctgccca gcgtgttctt ttgcgtctgc tcggcccgta
749281 gcgaacactg cgcccgctcg ggtgaatctc ccagcgcgac aagcaggttc accgtcatcg
749341 cggcgagcac cggttcgacg gccgcgcctc gatcgccgta gaagccggcc agctcgagca
749401 tcacgaagcc gtggatctgt gaccaaaact gcgccgcggt ggcaactatt gccgtgtcgt
749461 cgtcggctcc aagcgcggtc gcgaaccggc cggccagcag gcaccggtgc accgctcgca
749521 ccacatgcgc gaaactgggg tgctggtgtt cgatctcggc aaccttgagg gtcaacacgt
749581 cgcgcgctgg cacgttgatg ccgtgtgcgc tggtgctgcc gaacattagc cggtacatgt
749641 gcgggcgctc gatggcgtag cgccggtagg cggtgccgat ggccagcagg tcggcgaccg
749701 gatcggcggt ctgcgggacc gtcagcgcga catcgaactg gcgtagccct tcttcggcta
749761 tggcggcgat cagtccgcgc atcccgccga aatgggtgta caccgccatc gtcgaggtgc
749821 ctgctgcggc ggccaccttg cgggtctgca gcgcgtcggg cccgtgatcg tcgagcagtc
749881 gcacgccggc gtgcagcagc tcgtcgcgaa caccggtctg cgaggtcatc cttgccatgt
749941 tctcaccaag ggcgtaccgt tccaatatca gtgaaataac aatgttatag gagatcggca
750001 tgaccaccgc acaagccgcc gaatcccaaa acccatatct cgagggcttc ctggcgccgg
750061 tgagcaccga ggtaactgcc accgacctgc cggtcaccgg ccgcattccg gaacacctcg
750121 acgggcgtta tctgcgtaac ggccccaacc cggtcgcgga ggtcgacccg gccacctacc
750181 actggttcac cggcgacgcc atggtgcacg gagtcgcgct gcgcgacggg aaggcccgct
750241 ggtatcgcaa tcgctgggtc cgcacacccg cggtgtgcgc cgccctgggc gagcccattt
750301 cggcccggcc tcacccgcgc accgggatta tcgagggcgg tcccaacacc aacgtgctga
750361 cccacgccgg acgcaccctg gccttggttg aggccggcgt ggtcaactac gaactcaccg
750421 atgagctgga caccgtggga ccctgtgact tcgacggcac cctgcacggc ggttacaccg
750481 cccatccgca gcgtgatccg cacacgggtg aactgcacgc ggtgtcctac tcgttcgccc
750541 gcggacacag agtgcagtac tcggtgatcg gcaccgacgg acacgctcgt cggacggttg
750601 atatcgaggt ggcgggatcg ccgatgatgc acagcttctc cctgaccgac aactacgtgg
750661 tgatctacga cctgccggtg accttcgacc caatgcaggt ggtgccggcg tccgtgccac
750721 gctggctgca acggcccgcc aggttggtga tccagtcggt cctgggccgt gtccgcatcc
750781 ccgacccgat agcggcgttg ggcaaccgga tgcagggtca ctccgatcgc ctcccgtacg
750841 cctggaaccc cagctacccg gcgcgcgtcg gtgtcatgcc gcgcgagggt ggcaacgagg
750901 acgtgcggtg gttcgacatc gaaccctgct acgtatacca cccacttaac gcctactcgg
750961 agtgccggaa cggcgctgag gtgctggtgt tggacgtggt gcgctactca cggatgtttg
751021 atcgcgaccg gcggggtccc ggcggtgaca gccggccctc gctggatcgc tggaccatca
751081 acctggcgac cggtgcggtg accgccgaat gccgcgacga tcgggcgcag gagtttcccc
751141 gcatcaacga gactctggtg ggtgggccgc atcgcttcgc ctacaccgtc ggcatcgagg
751201 gtgggtttct cgtcggcgcc ggcgctgcgt tgtcgactcc gctgtataaa caggactgcg
751261 tgaccgggtc cagcacggtc gcctcgctcg atcccgacct gctgatcggc gagatggtgt
751321 tcgtgccgaa cccgtcggcg cgtgcagaag atgacgggat tctcatgggc tacggctggc
751381 accgcggccg cgacgaaggc cagctgctct tgctggatgc ccagactctc gagtcgatcg
751441 ccaccgtgca cctgccacag cgtgtgccga tgggcttcca cggcaactgg gcgccgacca
751501 cctgacggcg cctcgggtgc gatacagtga ctcataccac acaacgggcc ggtggcagcc
751561 acgagcgtcg acagaagggt ttcccatggg cgtcagcatc gaggtcaacg gactaacgaa
751621 gtccttcggg tcctcgagga tctgggaaga tgtcacgcta acgatccccg ccggggaggt
751681 cagcgtgctg ctgggcccat cgggtaccgg caaatcggtg tttctgaaat ctctgatcgg
751741 cctcctgcgg ccggagcgcg gctcgatcat catcgacggc accgacatca tcgaatgctc
751801 ggccaaggag ctttacgaga tccgcacatt gttcggcgtg ctgtttcagg acggtgccct
751861 gttcgggtcg atgaacctct acgacaacac cgcgttcccc ctgcgtgagc acaccaagaa
751921 aaaggaaagc gagatccgtg acatcgtcat ggagaagctg gccctagtcg gcctgggtgg
751981 ggacgagaag aagttccccg gcgagatctc cggcgggatg cgtaagcgtg ccggcctagc
752041 gcgtgccctg gtccttgacc cgcagatcat tctctgcgac gagcccgact cgggtctgga
752101 cccggttcgt accgcctacc tgagccagct gatcatggac atcaacgccc agatcgacgc
752161 caccatcctg atcgtgacgc acaacatcaa catcgcccgc accgtgccgg acaacatggg
752221 catgttgttc cgcaagcatt tggtgatgtt cgggccgcgg gaggtgctac tcaccagcga
752281 cgagccggtg gtgcggcagt tcctcaacgg ccggcgcatc ggcccgatcg gcatgtccga
752341 ggagaaggac gaggccacca tggccgaaga gcaggccctg ctcgatgccg gccaccacgc
752401 gggcggtgtc gaggaaatcg agggcgtgcc gccgcagatc agcgcgacac cgggcatgcc
752461 ggagcgcaaa gcggtcgccc ggcgtcaggc tcgggttcgc gagatgttgc acacgctgcc
752521 caaaaaggcc caggcggcga tcctcgacga tctcgagggc acgcacaagt acgcggtgca
752581 cgaaatcggc cagtaaggcg cgcggggatg cgaccgccgg accgccgcaa tcggatgatt
752641 tcgcgtaact tgccgcatat cacccggaga ccgaatcggg tcggccgctg gaggcggcgc
752701 ctgttcggga gctgatcacg caacgtttgt atctgctgcc gaccttccgt tggcggctcg
752761 cgtaggtggc acagtccgcg aagtgcttgg gccgctgatc aaggcgctcc cggagcacaa
752821 tccagacatg tcaggccgtc accgacgcac aggcgacggc cctcgagcag cgtgggaaga
752881 gccgggctcg tcgagtggat cacacatttc gaggcgctct cgtgtatcga gcggcacatc
752941 agccatgcgt gtctccttgt cctgccttct ccagaggaaa ccgctagtcg tcggcgctga
753001 cgaccctccg cactctgatg tcgggaaggt gacgctctgc gagttcgtag tcggcatcgt
753061 cgtggaggac tactaggccc ctggccgccg cagtgtcgca gatcagcaga tcgacaaccg
753121 acagggcacc caccgctccc gcccgggcga ggcggtgctg tgccgaatcg atccaccgcc
753181 acacggattt cggcactggc acatcggggt agacgtcacc aaacatccgg ctcatctggt
753241 cgaactcgtc cgcattccgc gctgatcggc agaactcggc tcgttgcggt tcgcacgacc
753301 cgacggcccg ctgagcagcg cggagttcca ggcctcggtg ggttccggtt gtcgttgcag
753361 ccgccaaacc gctgaggaat ccaccaggaa atagatcaaa tcccgagggc cttctcgtcg
753421 tcccgcgcgg ccacccagcc cttgtagtcc cagcctttcg cctactcgcg cgagcgggcc
753481 agggcctcga tgcgccgaaa ccgttcgacg taatcgcgca tcgcgaggtt cacggcttcc
753541 ttctttgtgt gcacggcggc gatgcgcatc acatcggcca gcgcttcgtc gtcgaggtcg
753601 atctgggtca ccgacacgac ggcctcctat gttgaagaca tatcacataa acatacgtaa
753661 ccaacatcgc gaggagaccg tctcgcgcct gctcagggca acgatatggc gccagtcaga
753721 ccaagcagca atacgatccc gggcaatagg ttggtcactt ggtgcgtgac gatgctggcc
753781 agtagaccgc cggaatagaa ccgtgccagc gcgatcggga tggccaccac caccagcagt
753841 ggagctcggg cgaactcgag atgggccaat gcgaagacca cggtggtaac caccagcgcc
753901 gcccaccgac cccagcgccg atccacagca ccccagagca gcccgcggta gatgatctct
753961 tcgcacagtg gcgcgacgaa caccacgacc agaaagacga ccagcgccca cggccaggac
754021 gcccgaacgc caccgaaaat ccttactaca gcggaattcg cttctggccc aacgatagcg
754081 gtgtagacca gcgacgccgg aatcgtgacc agcattccgc cgaaaccgaa catcaacccg
754141 agccgcagtc cgcgccacga ccagcgcagc cgcaagtcgg tgcggaggcc gttgccgcgg
754201 agcctggtga tgaggatggc cagcccggcg gcgaccaccg tgggggcggc tagcgcaagg
754261 gccagcaccc cggcagacac cgggccgtga ccggtaagga caaccgctaa cgaagtcgag
754321 gcgaccagga ataccagctc gacgaccaag aaggccccaa gtccccagcg gtgactgggg
754381 gctacggtat cggcacggcc cgcttccacg gctccgacgg tatcgaagtg tcaccgccac
754441 cggcgctgac gtcgagccgg cggacggccg gctgctacgc gcgcggtacc tcgtcgggcg
754501 gatcgggttc ggtcgatcga cgcgaaatat gttggcgact ggcaacttcc ggtgcttgcc
754561 acggtctcaa ctctcaccgc cgtgttgatc cggaccgacg gatgtgtcgc cgaaccgacc
754621 atatcgtggg cttgctgacg cgctcatcag tcggttcggg tggccacgtg caaccagccc
754681 ccgctcaaca ccccgtgctc gcccggagtg tttgacaggc ttcgtgcagg cgggccgggg
754741 acagccgggt gatgcggcgt cggaatgcgg tgcgtggcaa cgtatgaatg ttgtcgaagt
754801 tgacgacgca gtcgctcgga acacggtttt cgacggccgt gagctccaat tccgacacca
754861 ggcctcggcg ggtgcgggtt agggccacca caacgaccgc gccgatgcgg tctgccaccg
754921 gatctctggt aaggacaagt actggtctgt caccaccagg tgtggcggca aaccacaatt
754981 caccgcgccg catcggccca gtcggcccag tcctccgccg gcccccagtc ggcgatctca
755041 gccagtgcgt tctcgtcgtc cgtcaacggt cgctcggtgt aggcctggac atcctggtcc
755101 gcggccagcg cggccaagtg acgtcgcagc gcatcgcgca gcagctcgga gcggccgatg
755161 tgtaggcgac gcgcccacgc gtcggccagg tcgacgtcgt ggtcgtcggc gcggaagctg
755221 agcatcgtca tacatcgagt ttagagcgta tgacattgtc ggccggcgag cagacgcata
755281 agcccccgca cgctcggcgt gtcgggggct tatgcgactg ctcgcccggg gccgtcagcg
755341 gtcgccgagc aggctgacca tcccggccgc gtcgggaatg acgtgcacga catccgacag
755401 atcggcgaac gccgggtcag ccgagacaag agcggtcgcg ccggcgcttg cggcaaccgc
755461 cgcgagcacc gcgtcgcagg cttcaagccc tggcgttgtc tcgaacagcg tcaggccgcg
755521 cttcgaggtg gcctcgattg atggtgagta gcggcgagag cagttcggca tagtcacacg
755581 gcccagcgcg gcggcgtcgc tgcggtcgcg ccggcgggcg cgtacgtgga cgaactcctg
755641 gatcacctcg gcggtggtgg tcgcagcgat gcgttcgtcg gcgattgccg cgacgagatc
755701 gcggcaggga tcgcggagtg gatgctcggc gcctttggca tagacgagga cggtggtgtc
755761 gagcactatc atccgcggcg cgcccggagg gcctcgagtt cctgcttcag ctcccgcggc
755821 tcgggaacgg acatgtcggc ggcgtcgagc aggcgcctgc ccgcggactt gcggcgaccg
755881 gcggggctga cgaggcctcg atcaatggcc tcacgcacga cggttgcgac cgggacgcct
755941 cgctcgcgcg ccaccgcggt gatgcggcgg tggcactcgt cgtcgagcag gatctggagc
756001 cgatgcgcca gacgcatgct catacattta gcatgctgaa atttgggcgg cggctgccat
756061 tgcggtcgcg ttgacccgcg gacggcccag acgctgcggt tgtagcgtcg ataggcacgc
756121 gtattaggga ggaacaatgc cgcagccaag aacgcatctg ccgattccca gtgctgctcg
756181 caccgggctg atcacgtatg acgcgaagga tcccgacagc acctatccgc cgatcgagca
756241 gctgcgccca ccggcgggtg ccccgaatgt gttgctgatc ctgcttgacg atgtcgggtt
756301 cggtgcgtcg agcgcgttcg gaggcccatg caggacgtcg acggcggaac tgcttgccgg
756361 taacgggttg cggtacaacc ggtttcacac caccgcgctg tgctcgccga cgcgtcaggc
756421 gttgttaact ggacgcaacc atcactccgc cggcatgggc ggtatcaccg aaatcgccac
756481 cggtgcaccg ggatacagct cagtactacc gaacaccatg tcgccgatcg cgcggacgct
756541 aaagctcaac ggctacaaca ccgcccagtt cggcaagtgc cacgaagtcc cggtctggca
756601 gaccagcccg gtcgggccgt tcgacgcgtg gcccagcggc ggcggtggtt tcgaatactt
756661 ctacgggttt atcggtggcg aggctaacca gtggtatccg agtctgtacg agggcaccac
756721 gccggtcgag gtgaaccgca cgcccgagga gggttaccat ttcatggcgg acatgaccga
756781 caaggccctc ggctggatcg gacagcagaa ggcactggcc cccgaccggc cgttcttcgt
756841 gtacttcgcc ccgggcgcca cccacgcgcc ccaccacgtt ccgcgggagt gggccgacaa
756901 gtaccggggc cgcttcgatg tgggctggga cgcactgcga gaggaaacct tcgcccggca
756961 aaaggaactc ggggtgatcc cggcggactg ccagctgacc gcgcggcacg ccgaaatccc
757021 ggcgtgggac gacatgccgg aggacctcaa acccgtgcta tgccggcaga tggaggtcta
757081 cgcgggcttt ctggaataca ccgaccacca cgtcggccgg ctcgtcgacg gcctgcagcg
757141 cctcggtgtg ctcgacgaca cgctggtgtt ctacatcatc gacgacaacg gcgcctcggc
757201 cgagggcacg atcaacggca cctacaacga gatgttgaac ttcaacggcc tggccgacat
757261 cgagacgccg cggttcatga ccgaccggct cgacaagttc ggcgggccgg agtcctacaa
757321 ccactattcg gtgggttggg cgcatgcgat ggataccccc tatcagtgga ccaaacaagt
757381 ggcctcgcac tggggtggca cgcgtaacgg cacgattgtg cactggccca acggaattgc
757441 cgccaagggg gagatgcgct ggcagtttca ccacgtcatc gacgtggcgc cgaccatcct
757501 ggaggcggcg gggttgccgg aaccgttatt cgtcaacggc gtgcagcaac accccatcga
757561 aggggtcagc atggcctatt cgttcgacga cgcgcaggcg ccggatcggc acgagacgca
757621 gtatttcgag atgttcggaa accggggcat ctaccacaag ggttggaccg cggtgaccaa
757681 gcacaagacg ccgtggattt tggttggcga gcagaccgtc gcgttcgacg acgacgtgtg
757741 ggagctctac gacaccacca aggattggag ccaggccaaa gacttggcca aggagatgcc
757801 ggaaaagctg catgagctgc agcggctgtg gctgatcgag gcgacgcgct acaacgtgct
757861 tccgctggac gacgacaccg ccagccgcat caaccccgat ctggcgggca ggccggtgct
757921 catcaggggc aacacccagg tgctgttttc gaacatgggc cggttgtcgg agaactgtgt
757981 gctcaacctc aagaacaaat cgcacacggt gaccgctgag gtcgaggtgc ccgagaccgg
758041 tgctgagggc gtgatcgtcg cgcagggcgc cagcatcggc ggctggagcc tgtatgccaa
758101 cgacggcaag ctcaagtact gctacaacct gggtggtatc aagcacttct acgccgagtc
758161 cgccgacccg ctgccggccg gcgcccatca ggtgcgcatg gaattcgctt atgccggtgg
758221 cggtttgggc aagggcggcg aggtaactct ttatgtcgac ggccaacagg tcggcgaagg
758281 acatgtcgaa gccacccttg ccatcgtctt ctcggccgac gacggctgcg atgtcggcat
758341 ggattcgggc tcgcccgtct cacccgacta tgccccgggg agtaacgcgt tcaacgggcg
758401 gatcaagggc gtgcagctcg cgatcgccga ggccgccgct gctgcgggcc atctggtcga
758461 cccggagcac gcgatccgca tcgcgctggc gcgccaatag ggccgcacag tcaaacgggg
758521 aggggacggc gatggaaaag tcacggtgcc acgctgtcgc acatggaggt gggtgtgcgg
758581 gatctgcgaa atcgcacaag tcaggtggtc gatgcggtca aggccggggt gccggtgact
758641 ctcacggtac acggggagcc ggtcgccgat atcgtgccgc atcggcgccg catccgctgg
758701 ctgtcggggc gcatctgcgc gatgagctcg ccaagcgctc ggccgacccg cgcctcaccg
758761 atgaactcaa cgacttggcc ggtcataccc tcgacgacct gtgaccgagg gcgaggtcgg
758821 ggtaggcctg ctagatacgt cggtcttcat tgcgcgcgag agcggcggtg caatcgcgga
758881 cctgcctgaa cgcgtggcgc tttcggttat gacgatcggt gagctgcaac tcggtctgct
758941 caatgctggc gattcggcga cccgatcacg acgcgccgac accctcgcgc tagcgcgcac
759001 ggccgatcag atccctgtca gtgaagcggt gatgatttcg ttggctcgac tcgtcgcgga
759061 ctgccgagcc gcgggcgtgc ggcggtcggt gaagctgacc gacgctctca ttgcggcaac
759121 cgcggagatc aaggtgtgac accgaggact gatgaaggtg ccgctgcacc ctgcctgatg
759181 cctgacgtca cgatgcccgt gaagcgtggt gatgcccggg gagctttggg tgtgggtcca
759241 gctttgttcg tggtgagcgt gagcagctcg ctggtgaggg ccaggagctg tcgttgcacg
759301 gcggattgat cgattcgacc gcatccatct ggagctactg ccccagaccg gactcgcagc
759361 cttggcaagc cgctacgcgg gcattctcac ctgaggcaac gaagggcgct atgcgcgcat
759421 tgtgggtgag tcaacgcgag gacttgacgg cagacgctaa acgggtcaat ctgttgggca
759481 gcatgcgccg catgtggcca aaggaagtcg agatcgccag ctagcgccga tatccgggga
759541 tggttattgc cgggtatttg aggaatgcgc cgtcctgcgc tattgttgga cgttgcgctg
759601 gctacttcct gcccacctca cccgccactt gacaccgtgg tcttagtctg agcccagttt
759661 gcggctcagc ggtttagttg cgtgcgtgag atccggacag atcgttcgcc ggccgaaacc
759721 gacaaaatta tcgcggcgaa cgggcccgtg ggcaccgctc ctctaagggc tctcgttggt
759781 cgcatgaagt gctggaagga tgcatcttgg cagattcccg ccagagcaaa acagccgcta
759841 gtcctagtcc gagtcgcccg caaagttcct cgaataactc cgtacccgga gcgccaaacc
759901 gggtctcctt cgctaagctg cgcgaaccac ttgaggttcc gggactcctt gacgtccaga
759961 ccgattcgtt cgagtggctg atcggttcgc cgcgctggcg cgaatccgcc gccgagcggg
760021 gtgatgtcaa cccagtgggt ggcctggaag aggtgctcta cgagctgtct ccgatcgagg
760081 acttctccgg gtcgatgtcg ttgtcgttct ctgaccctcg tttcgacgat gtcaaggcac
760141 ccgtcgacga gtgcaaagac aaggacatga cgtacgcggc tccactgttc gtcaccgccg
760201 agttcatcaa caacaacacc ggtgagatca agagtcagac ggtgttcatg ggtgacttcc
760261 cgatgatgac cgagaagggc acgttcatca tcaacgggac cgagcgtgtg gtggtcagcc
760321 agctggtgcg gtcgcccggg gtgtacttcg acgagaccat tgacaagtcc accgacaaga
760381 cgctgcacag cgtcaaggtg atcccgagcc gcggcgcgtg gctcgagttt gacgtcgaca
760441 agcgcgacac cgtcggcgtg cgcatcgacc gcaaacgccg gcaaccggtc accgtgctgc
760501 tcaaggcgct gggctggacc agcgagcaga ttgtcgagcg gttcgggttc tccgagatca
760561 tgcgatcgac gctggagaag gacaacaccg tcggcaccga cgaggcgctg ttggacatct
760621 accgcaagct gcgtccgggc gagcccccga ccaaagagtc agcgcagacg ctgttggaaa
760681 acttgttctt caaggagaag cgctacgacc tggcccgcgt cggtcgctat aaggtcaaca
760741 agaagctcgg gctgcatgtc ggcgagccca tcacgtcgtc gacgctgacc gaagaagacg
760801 tcgtggccac catcgaatat ctggtccgct tgcacgaggg tcagaccacg atgaccgttc
760861 cgggcggcgt cgaggtgccg gtggaaaccg acgacatcga ccacttcggc aaccgccgcc
760921 tgcgtacggt cggcgagctg atccaaaacc agatccgggt cggcatgtcg cggatggagc
760981 gggtggtccg ggagcggatg accacccagg acgtggaggc gatcacaccg cagacgttga
761041 tcaacatccg gccggtggtc gccgcgatca aggagttctt cggcaccagc cagctgagcc
761101 aattcatgga ccagaacaac ccgctgtcgg ggttgaccca caagcgccga ctgtcggcgc
761161 tggggcccgg cggtctgtca cgtgagcgtg ccgggctgga ggtccgcgac gtgcacccgt
761221 cgcactacgg ccggatgtgc ccgatcgaaa cccctgaggg gcccaacatc ggtctgatcg
761281 gctcgctgtc ggtgtacgcg cgggtcaacc cgttcgggtt catcgaaacg ccgtaccgca
761341 aggtggtcga cggcgtggtt agcgacgaga tcgtgtacct gaccgccgac gaggaggacc
761401 gccacgtggt ggcacaggcc aattcgccga tcgatgcgga cggtcgcttc gtcgagccgc
761461 gcgtgctggt ccgccgcaag gcgggcgagg tggagtacgt gccctcgtct gaggtggact
761521 acatggacgt ctcgccccgc cagatggtgt cggtggccac cgcgatgatt cccttcctgg
761581 agcacgacga cgccaaccgt gccctcatgg gggcaaacat gcagcgccag gcggtgccgc
761641 tggtccgtag cgaggccccg ctggtgggca ccgggatgga gctgcgcgcg gcgatcgacg
761701 ccggcgacgt cgtcgtcgcc gaagaaagcg gcgtcatcga ggaggtgtcg gccgactaca
761761 tcactgtgat gcacgacaac ggcacccggc gtacctaccg gatgcgcaag tttgcccggt
761821 ccaaccacgg cacttgcgcc aaccagtgcc ccatcgtgga cgcgggcgac cgagtcgagg
761881 ccggtcaggt gatcgccgac ggtccctgta ctgacgacgg cgagatggcg ctgggcaaga
761941 acctgctggt ggccatcatg ccgtgggagg gccacaacta cgaggacgcg atcatcctgt
762001 ccaaccgcct ggtcgaagag gacgtgctca cctcgatcca catcgaggag catgagatcg
762061 atgctcgcga caccaagctg ggtgcggagg agatcacccg cgacatcccg aacatctccg
762121 acgaggtgct cgccgacctg gatgagcggg gcatcgtgcg catcggtgcc gaggttcgcg
762181 acggggacat cctggtcggc aaggtcaccc cgaagggtga gaccgagctg acgccggagg
762241 agcggctgct gcgtgccatc ttcggtgaga aggcccgcga ggtgcgcgac acttcgctga
762301 aggtgccgca cggcgaatcc ggcaaggtga tcggcattcg ggtgttttcc cgcgaggacg
762361 aggacgagtt gccggccggt gtcaacgagc tggtgcgtgt gtatgtggct cagaaacgca
762421 agatctccga cggtgacaag ctggccggcc ggcacggcaa caagggcgtg atcggcaaga
762481 tcctgccggt tgaggacatg ccgttccttg ccgacggcac cccggtggac attattttga
762541 acacccacgg cgtgccgcga cggatgaaca tcggccagat tttggagacc cacctgggtt
762601 ggtgtgccca cagcggctgg aaggtcgacg ccgccaaggg ggttccggac tgggccgcca
762661 ggctgcccga cgaactgctc gaggcgcagc cgaacgccat tgtgtcgacg ccggtgttcg
762721 acggcgccca ggaggccgag ctgcagggcc tgttgtcgtg cacgctgccc aaccgcgacg
762781 gtgacgtgct ggtcgacgcc gacggcaagg ccatgctctt cgacgggcgc agcggcgagc
762841 cgttcccgta cccggtcacg gttggctaca tgtacatcat gaagctgcac cacctggtgg
762901 acgacaagat ccacgcccgc tccaccgggc cgtactcgat gatcacccag cagccgctgg
762961 gcggtaaggc gcagttcggt ggccagcggt tcggggagat ggagtgctgg gccatgcagg
763021 cctacggtgc tgcctacacc ctgcaggagc tgttgaccat caagtccgat gacaccgtcg
763081 gccgcgtcaa ggtgtacgag gcgatcgtca agggtgagaa catcccggag ccgggcatcc
763141 ccgagtcgtt caaggtgctg ctcaaagaac tgcagtcgct gtgcctcaac gtcgaggtgc
763201 tatcgagtga cggtgcggcg atcgaactgc gcgaaggtga ggacgaggac ctggagcggg
763261 ccgcggccaa cctgggaatc aatctgtccc gcaacgaatc cgcaagtgtc gaggatcttg
763321 cgtaaagctg tcgcaaaatt actaaacccg ttaggggaaa gggagttacg tgctcgacgt
763381 caacttcttc gatgaactcc gcatcggtct tgctaccgcg gaggacatca ggcaatggtc
763441 ctatggcgag gtcaaaaagc cggagacgat caactaccgc acgcttaagc cggagaagga
763501 cggcctgttc tgcgagaaga tcttcgggcc gactcgcgac tgggaatgct actgcggcaa
763561 gtacaagcgg gtgcgcttca agggcatcat ctgcgagcgc tgcggcgtcg aggtgacccg
763621 cgccaaggtg cgtcgtgagc ggatgggcca catcgagctt gccgcgcccg tcacccacat
763681 ctggtacttc aagggtgtgc cctcgcggct ggggtatctg ctggacctgg ccccgaagga
763741 cctggagaag atcatctact tcgctgccta cgtgatcacc tcggtcgacg aggagatgcg
763801 ccacaatgag ctctccacgc tcgaggccga aatggcggtg gagcgcaagg ccgtcgaaga
763861 ccagcgcgac ggcgaactag aggcccgggc gcaaaagctg gaggccgacc tggccgagct
763921 ggaggccgag ggcgccaagg ccgatgcgcg gcgcaaggtt cgcgacggcg gcgagcgcga
763981 gatgcgccag atccgtgacc gcgcgcagcg tgagctggac cggttggagg acatctggag
764041 cactttcacc aagctggcgc ccaagcagct gatcgtcgac gaaaacctct accgcgaact
764101 cgtcgaccgc tacggcgagt acttcaccgg tgccatgggc gcggagtcga tccagaagct
764161 gatcgagaac ttcgacatcg acgccgaagc cgagtcgctg cgggatgtca tccgaaacgg
764221 caaggggcag aagaagcttc gcgccctcaa gcggctgaag gtggttgcgg cgttccaaca
764281 gtcgggcaac tcgccgatgg gcatggtgct cgacgccgtc ccggtgatcc cgccggagct
764341 gcgcccgatg gtgcagctcg acggcggccg gttcgccacg tccgacttga acgacctgta
764401 ccgcagggtg atcaaccgca acaaccggct gaaaaggctg atcgatctgg gtgcgccgga
764461 aatcatcgtc aacaacgaga agcggatgct gcaggaatcc gtggacgcgc tgttcgacaa
764521 tggccgccgc ggccggcccg tcaccgggcc gggcaaccgt ccgctcaagt cgctttccga
764581 tctgctcaag ggcaagcagg gccggttccg gcagaacctg ctcggcaagc gtgtcgacta
764641 ctcgggccgg tcggtcatcg tggtcggccc gcagctcaag ctgcaccagt gcggtctgcc
764701 caagctgatg gcgctggagc tgttcaagcc gttcgtgatg aagcggctgg tggacctcaa
764761 ccatgcgcag aacatcaaga gcgccaagcg catggtggag cgccagcgcc cccaagtgtg
764821 ggatgtgctc gaagaggtca tcgccgagca cccggtgttg ctgaaccgcg cacccaccct
764881 gcaccggttg ggtatccagg ccttcgagcc aatgctggtg gaaggcaagg ccattcagct
764941 gcacccgttg gtgtgtgagg cgttcaatgc cgacttcgac ggtgaccaga tggccgtgca
765001 cctgcctttg agcgccgaag cgcaggccga ggctcgcatt ttgatgttgt cctccaacaa
765061 catcctgtcg ccggcatctg ggcgtccgtt ggccatgccg cggctggaca tggtgaccgg
765121 gctgtactac ctgaccaccg aggtccccgg ggacaccggc gaataccagc cggccagcgg
765181 ggatcacccg gagactggtg tctactcttc gccggccgaa gcgatcatgg cggccgaccg
765241 cggtgtcttg agcgtgcggg ccaagatcaa ggtgcggctg acccagctgc ggccgccggt
765301 cgagatcgag gccgagctat tcggccacag cggctggcag ccgggcgatg cgtggatggc
765361 cgagaccacg ctgggccggg tgatgttcaa cgagctgctg ccgctgggtt atccgttcgt
765421 caacaagcag atgcacaaga aggtgcaggc cgccatcatc aacgacctgg ccgagcgtta
765481 cccgatgatc gtggtcgccc agaccgtcga caagctcaag gacgccggct tctactgggc
765541 cacccgcagc ggcgtgacgg tgtcgatggc cgacgtgctg gtgccgccgc gcaagaagga
765601 gatcctcgac cactacgagg agcgcgcgga caaggtcgaa aagcagttcc agcgtggcgc
765661 tttgaaccac gacgagcgca acgaggcgct ggtggagatt tggaaggaag ccaccgacga
765721 ggtcggtcag gcgttgcggg agcactaccc cgacgacaac ccgatcatca ccatcgtcga
765781 ctccggcgcc accggcaact tcacccagac tcgaacgctg gccggtatga agggcctggt
765841 gaccaacccg aagggtgagt tcatcccgcg tccggtcaag tcctccttcc gtgagggcct
765901 gaccgtgctg gagtacttca tcaacaccca cggcgctcga aagggcttgg cggacaccgc
765961 gttgcgcacc gccgactccg gctacctgac ccgacgtctg gtggacgtgt cccaggacgt
766021 gatcgtgcgc gagcacgact gccagaccga gcgcggcatc gtcgtcgagc tggccgagcg
766081 tgcacccgac ggcacgctga tccgcgaccc gtacatcgaa acctcggcct acgcgcggac
766141 cctgggcacc gacgcggtcg acgaggccgg caacgtcatc gtcgagcgtg gtcaagacct
766201 gggcgatccg gagattgacg ctctgttggc tgctggtatt acccaggtca aggtgcgttc
766261 ggtgctgacg tgtgccacca gcaccggcgt gtgcgcgacc tgctacgggc gttccatggc
766321 caccggcaag ctggtcgaca tcggtgaagc cgtcggcatc gtggccgccc agtccatcgg
766381 cgaacccggc acccagctga ccatgcgcac cttccaccag ggtggcgtcg gtgaggacat
766441 caccggtggt ctgccccggg tgcaggagct gttcgaggcc cgggtaccgc gtggcaaggc
766501 gccgatcgcc gacgtcaccg gccgggttcg gctcgaggac ggcgagcggt tctacaagat
766561 caccatcgtt cctgacgacg gcggtgagga agtggtctac gacaagatct ccaagcggca
766621 gcggctgcgg gtgttcaagc acgaagacgg ttccgaacgg gtgctctccg atggcgacca
766681 cgtcgaggtg ggccagcagc tgatggaagg ctcggccgac ccgcatgagg tgctgcgggt
766741 gcagggcccc cgcgaggtgc agatacacct ggttcgcgag gtccaggagg tctaccgcgc
766801 ccaaggtgtg tcgatccacg acaagcacat cgaggtgatc gttcgccaga tgctgcgccg
766861 ggtgaccatc atcgactcgg gctcgacgga gtttttgcct ggctcgctga tcgaccgcgc
766921 ggagttcgag gcagagaacc gccgagtggt ggccgagggc ggtgagcccg cggccggccg
766981 tccggtgctg atgggcatca cgaaggcgtc gctggccacc gactcgtggc tgtcggcggc
767041 gtcgttccag gagaccactc gcgtgctgac cgatgcggcg atcaactgcc gcagcgataa
767101 gctcaacggt ctgaaggaaa acgtgatcat cggcaagctg atcccggccg gtaccggtat
767161 caaccgctac cgcaacatcg cggtgcagcc caccgaggag gcccgcgctg cggcgtacac
767221 catcccgtcg tatgaggatc agtactacag cccggacttc ggtgcggcca ccggtgctgc
767281 cgtcccgctg gacgactacg gctacagcga ctaccgctag gtgggcgagc agacgcagaa
767341 tcgcacgcga aatgcctgcg cgatgcgatt ctgcgtctgc tcgccgtggt ggatgagccg
767401 gtcttgcatc gccgatgcgg gaaacccatg catgcgttgg ggcacgacgc cggcctggcc
767461 gccagattgg cgctgcccgc cgccccgttc aacatgagtg gcaatcccgc catctgcctg
767521 cctgcggggg acacgtcgtg aggaaccccg gtcggggttt agtttatcgg ccgtgaattc
767581 gccgaacggt tgctcgtcca agccggccac gcattccagc aggccactgc gttccatcgc
767641 cgacgcccag gcatggcctg ggttggtgat tgcggccgcc gagtcaaaca accgtgaact
767701 cgcgcgtcgt cgcgctgaac gctgtaagca tgccgttgcg atcgcgtgcg gtgccgtggt
767761 ggacgatgcg gtattgcccg ggcgtggtat cgccgggaac atcccagcga atgctgacat
767821 gcgatccggc ccgcccttgg cgctgccagc gaaagctcgt ggcccagtcg ccgtcgtcag
767881 caatccgcac ccagctggca ccttcccggc ggaccacttc gaggtaggtg ccgccgcggc
767941 gcagatcgtt attgggcagc gcgctgacga aaacggcttc caccgcctga cccggtcggt
768001 acgtcgccga gggctcggcg atgaccgctc cgaacgaccc ggcatcggcg ggcgcgccgc
768061 gcacccagct cagctcccgg gtgggccgcg gccggcgacc gagcgtcacc ggacggccgt
768121 cgcgcatggc ctcggcgagt tcggccacgg tctgcatgag ggcgcacagt tcccatcgac
768181 cgaacaacgt gctgccgccc tcgtagcgct gttcgagata ctcttcgggc gttgtcacgt
768241 aatggatgta ggcgttggtg tagcccacgc agagcacgtc ggccaggtcg gcgccaacaa
768301 tcgaagccac catgcggcgc agcctaagcc ccgcgacgat ggtcggttcg cccggaatac
768361 cgatcagata gaggcgaccg attcgcacga gctgaacggg aacaatttcc tggacaaagg
768421 ggtgtatccg gttcggcagg cgtgcgggca tcacaatgcc tttgggggcc tgtgccgctg
768481 ccgtcggcct tgccagccgg tacatggcgc gggatagtct gtcccagaac gggtttcgcc
768541 cttggcgaaa gccatggaag cccgggccct cgtcggtgcc tgccatggcc ccggcgccaa
768601 acatcggacg cccggtgcgg cgctcttcac cgtctggtgt gtactcgccg cgcacgagca
768661 cagaaccgag atcgacatag gtgaaccggg catcaatgcc agcgccgatg ggcgtcgctc
768721 cgctcaactg cgtgaaagca tcctcgaact ggcacaaccc ggtacgacgg gtgttgtcga
768781 attcccggtc tggtggggcc tcgggagaaa ggggcccgtc gacattcggg ctcatgtcgc
768841 ccggattcgt ctgtgcgaag gcggcgatga agtcgggctg gccggcgaga taatccgcgc
768901 cgcccacggt gcgttcccag tgataggccg cgaaaccctt gttgtctccg gagatgaggt
768961 ggttgcgatt cgtcatgctc gtaccgtggg tagcgaagaa atggatcacg cccacggtgg
769021 cctcgccccg gtcgatacgc acgagcgtgg tatgcgggtc gacgcgtttc gggaagaacg
769081 ccttgtcggc cggcgggttg cggtcgaacg ctgatgggga tcgattgatg cttgcgccgt
769141 acagctcgcc gtgcgagagc gaaacctcgg cgggcgccac atcggcatgc gcatgttcca
769201 ccgattcgac aattccgtcg acgatcgccg caaaggttgc cggccgaaag ccgctcgtgg
769261 tcaggttgta cagcaggtat ccgcagtacc cgccaggccc ggcgtgggtg tgggtcgccg
769321 tgatcagtgt gttctgctcc gagtaggtat cgccatacaa atcggccaac cggcgcagca
769381 cttcctcatt cacgttttgc atgggcagcg gcagttcggc gacaatcagc agcaaccgcg
769441 cgtccccgtc ctgggaatcg tcccggaaca caaacgcccg tgacctaagt cgctggtgaa
769501 tgccggcggt gcgctggtcg gacttgccgt agccgagcat gccgcagtcc gccgcctcac
769561 cagtgatgtc ggcgatgccg cgccctacac taagcattgc ctaatcctcc gcaccagcag
769621 caaatttcac gagcgctgac tacgcgctgc tccggggaaa cgtatcccac aaggagaaac
769681 actttatgcg ccggggccca cgaatacgga cggcagcatc ccgtgccgcg gctggccgga
769741 cgtgatccga gggtgtgggt ctcaccagat cggtctcact agacttgggt tgtgctcatt
769801 ggttcgcatg tcagcccaac cgatccgctg gccgcagcgg aggccgaagg cgctgacgta
769861 gtgcagattt tccttggcaa tccgcagagc tggaaggctc ccaagccgcg ggacgacgcc
769921 gccgcgctga aagccgcgac cctgcccatc tacgtgcatg cgccctacct gatcaacctt
769981 gcgtcggcga acaatcgcgt gcggatcccg tcgcgcaaga tcctgcaaga gacctgtgct
770041 gcggcggccg acattggcgc agcggcggtg atcgtgcacg gtgggcacgt cgccgacgac
770101 aacgacatcg acaagggctt ccagcgctgg cgcaaggcgc tggaccggct ggaaaccgag
770161 gttcccgtct acctggaaaa caccgccggc ggcgatcacg cgatggcgcg ccgcttcgac
770221 accatcgccc ggctctggga cgtcatcggc gacaccggaa tcgggttttg cctggacacc
770281 tgccacacct gggcggccgg cgaggcgctg accgatgccg tcgatcggat caaagcaatt
770341 accggccgca tcgatctggt gcactgcaac gactccaggg acgaagcggg atcgggccgt
770401 gaccgccacg ccaacctcgg cagcggccag attgatcctg acctgctggt ggctgccgtc
770461 aaggcggccg gcgcgccggt gatctgcgaa accgccgacc aaggtcgcaa ggacgacatc
770521 gcgtttctgc gggaaagaac cggcagctga cttcaagccc cgcggcacct accgttgact
770581 tatgctccgc agggtcgcca tactgctcgc cgctgtgctt gcgttcgcgg gctgctcggg
770641 gggaacgagg ttggcggcgg gcttcggcaa tggcaatagc gtgcacaccc tcgatgtcga
770701 tggagccggc cgcagctacc ggctttataa gcccgtcggg ttgccgtcct cggcgccgct
770761 ggtcgtcatg ttgcacggcg ggttcggcag cgccaagcaa gccgaaaggt cttatggctg
770821 ggacgaattg gccgactccg agaagttcct cgtcgcctac cccgatggct atcacagggc
770881 ttggaatgcc aatggcggag gctgctgcgg ccggcccgca cgtgaaggcg tcgacgacat
770941 cggcttcgtc cgcgcggtcg tcgccgacat cgccaacaat gtcagcatcg accccgcccg
771001 ggtctacgtc acgggcatga gcaacggtgc catcatgtcc tacacgctgg cctgcaacac
771061 cagcatcttc gcggcgatcg gcgtcgtttc gggcacgcaa ctagacccct gtcagtcccc
771121 gcgtccggtg tcggtcatcc acatccatgg cacggccgat ccgctggtcc gctaccacgg
771181 cgggcccggc gccgggttcg cgcgcatcga cggtccgccg gtgcccgatc tcaatgcgtt
771241 ctggcgcgag gtcaaccggt gcggcgcgct ggataccacg accgaaggtc cggtcaccac
771301 atcgggcgcc acatgcgccg acaatcgccg tgtcgtgctg ctcaccgtcg atgacgccgg
771361 ccaccgatgg ccgtcatttg ccacccagac actgtggcga ttctttgcag cgcacttcag
771421 atgaggacaa aaccatccgt tacattctct tgtgcagttg tagaaaaaac gtaacatggt
771481 ggcatgtcag atacgcatgt cgtcaccaac caggttccgc ccttggagaa ctacaatccc
771541 gcgtcatccc cggtgctcat cgaggctctg atccaggagg gtggccagtg gggcctggat
771601 gaagtaaacg aggtcggggc aatttctgcc agctgccaag cccaacgctg gggagagctt
771661 gcagaccgca accggcccat cctgcatacc cacgacgctt acgggtaccg ggtcgatgag
771721 gtggagtacg acccggccta ccacgagctg atgcgtaccg cgatcaccca tggcatgcac
771781 gccgcaccgt gggctgacga ccgcccgggt gcgcacgtgg tgcgagcggc caagacatcg
771841 gtgtggaccg tcgagccggg ccatatctgc cccatctcga tgacctacgc cgtcgttccg
771901 gcgctgcggt ataactccga gctggctgcg gtctacgagc cgctgctgac cagtcgtgag
771961 tacgacccgg agctgaagcc ggcgaccacg aaggccggca tcaccgccgg catgtcgatg
772021 accgagaagc agggtggctc cgacgtgcgc gctggcacca cccaggcgac cccgaatgcg
772081 gacggcagct acagcttgac cggccacaag tggttcactt cggcgccgat gtgcgacatc
772141 ttcctggtgc tcgcgcaggc accggacggg ctgtcgtgct tcctgctgcc gcgggtgctg
772201 cccgacggca cccgcaaccg aatgttcttg cagcggctca aggacaagct cggcaaccac
772261 gcaaacgcct cgagcgaggt cgaatacgac ggtgccgtcg cgtggctggt gggcgaggag
772321 ggccgcggcg tgccgaccat catcgagatg gtcaacctca cccggctgga ctgcgctctg
772381 ggcagtgcca ccagcatgcg caccggccta acccgcgccg tccaccatgc ccagcatcgg
772441 aaggcgttcg gcgcctacct gatcgaccag ccgttgatgc gcaacgtgct ggccgacctg
772501 gcggtggagg ccgaggccgc caccatcgtg gcaatgcgga tggccggtgc caccgacaac
772561 gcggtgcgcg ggaacgagac cgaagcgctg ctgcgtcgca tcggcctggc ggccgccaag
772621 tactgggtgt gcaagcgctc caccgctcac gccgccgaag cgctggagtg cctgggcggc
772681 aacggttatg tcgaggattc cgggatgccc cggctctacc gggaggcgcc gttgatgggc
772741 atctgggagg gctcgggcaa tgtcagcgcg ctagatacct tgcgcgccat ggcaacccgg
772801 cccgcatgcg tcgaggtgct gtttgacgag ctggcccgca gcgcaggcca ggaccccagg
772861 ctggacggcc acgtcgaaag gctgcgtccg cagctgggcg atcttgacac gatcggttat
772921 cgagcccgca agattgccga agacatctgc ctggcgttgc agggatcgtt gttggtgcgc
772981 cacggacatc ccgccgtcgc cgaggcgttt ctggccactc ggctcggcgg ccagtggggc
773041 ggagcgtacg gcaccatgcc ggccggtctg gatctcgcgc ccatcctcga gcgtgcgctg
773101 gtaaaaggct gagcggccgc tgatgacaca cgcgatcagg ccggtcgatt tcgacaacct
773161 gaagacgatg acctatgagg tcaccggtcg gattgcgcgg atcaccttca accggccgga
773221 gaagggcaac gcgatcatcg cagacacccc gctggagttg tctgctctgg tggagcgtgc
773281 cgatctggat ccaggcgtgc atgtcattct ggtgtccggt cgcggcgagg gattctgtgc
773341 cggcttcgac ctgtccgcct acgccgaggg gtcgtcgtcg accgggggcg gcggcgcata
773401 ccaaggcacg gtgctagatg gcaagaccca ggccgtcaac cacctaccga accagccgtg
773461 ggacccgatg atcgactacc agatgatgag ccggttcgtg cgcggattcg ccagtctgat
773521 gcatgccgac aagccgacgg tggtcaagat ccacggctac tgcgtggccg gcggcaccga
773581 catcgcgctg cacgccgatc aggtgatcgc cgccgccgac gccaagatcg gctacccgcc
773641 cacccgggtg tggggggtgc cggcggcggg cctgtgggcg caccggctcg gcgaccagcg
773701 ggccaaacgg ctgctgttca ccggcgattg catcaccggc gcgcaggccg ccgagtgggg
773761 cctggcggtc gaggcgccgg agccggctga cctcgacgag cggaccgagc gactggtggc
773821 ccggatcgcc gcactgccgg tcaatcaatt gatcatggtc aagctcgcgc tcaattccgc
773881 tctgctgcaa cagggtgtgg ccaccagcag gatggtcagc accgtgttcg acggcgccgc
773941 tcggcacaca cccgaggggc acgcgtttgt cgccgacgcg gtcgagcacg gcttccggga
774001 tgcggtgcgg cgccgtgacg agccgtttgg cgactacggc cgtcaagcat cgcgggtgta
774061 accatgccgg ccatgaccgc ccgttcggtg gtactcagcg tgctgctcgg tgctcatccc
774121 gcgtgggcca ccgcaagcga attgatccag ctgacagcgg atttcggtat caaggagacg
774181 acgttgcggg tcgcgctgac ccgcatggtc ggtgccgggg atctggtccg gtccgcggac
774241 ggctaccggc tctcggatcg gttgctggcc cgccagcgcc gacaagatga ggccatgcgc
774301 ccacggaccc gcgcttggca cggaaactgg cacatgctga ttgtcaccag catcggcacc
774361 gatgctcgta cccgggccgc actgcgaacc tgcatgcacc acaagcgttt cggtgaattg
774421 cgggaagggg tgtggatgcg gccggacaat ctcgacctcg acttggagtc cgacgttgcg
774481 gcccgggtta ggatgctgac ggcccgcgac gaggcccccg ccgacttggc cgggcagctg
774541 tgggatctgt cggggtggac cgaggccggc caccggttgc tcggcgacat ggcagcggcc
774601 accgacatgc ccgggcgatt tgtggtggct gcggcgatgg tgcgccacct gctcaccgat
774661 ccgatgttgc ccgctgaact gttgcccgcc gactggccgg gcgccgggtt acgggcggcg
774721 taccacgact tcgccactgc aatggcgaaa cgacgcgatg caactcaact cctggaggtg
774781 acatgagtga tctggtgcgt gtggagcgca aaggtcgggt gaccacggtg attctgaacc
774841 ggccggcctc ccgcaacgcg gtcaacggcc cgaccgccgc ggcgttgtgc gcggcgttcg
774901 agcaattcga ccgggacgac gccgcgtcgg tggccgtact ctggggtgcg ggtggaacct
774961 tttgtgcggg agccgatttg aaggcctttg gcacaccgga ggccaactct gtgcaccgga
775021 cgggtcccgg cccgatgggg ccgtcacgaa tgatgctgtc caaacctgtg atcgccgccg
775081 tcagcggcta cgccgtcgcc ggggggctgg aattggcact gtggtgcgac ctgcgggtgg
775141 ccgaggaaga cgccgtgttc ggtgtgtttt gccgtcgctg gggggtaccg ctcatcgacg
775201 gcggcaccgt gcgactgcca cggctgatcg ggcacagccg cgcgatggac atgatcctca
775261 ctggccgtgg ggtgccggcc gacgaagcgc tggccatggg gttggccaat cgggtggtgc
775321 ccaagggtca agcccgacag gcggctgagg agttggcggc gcaattggcc gcgctgccgc
775381 agcagtgtct gcgatcggat cggctgtcgg cgctgcacca gtggggcctg cccgagtccg
775441 cggcgctcga cctcgagttc gccagcatcg cgcgggtggc cggcgaggcg ctagaggggg
775501 cgagacggtt cgccgcgggt gccggtcggc atggggcccc ggcacctcgg gccgaacagg
775561 gcgacacgct ttaggcgggt acggctcaga ccaaggcgaa ggtccgtgcc gatgccggcg
775621 agggccacgg ctgcggaatg ggtcgttgcc ggacaacctg gggccaccag aaccactttc
775681 cgaggagggc cgcgatcgac ggtgtcatga acgaccggac gatcagggtg tcgaagagca
775741 ggcccatacc gatggtggtg ccaacctggg ccatcacggt cagctcgctg acggcaaacg
775801 acatcatggt gaaggcaaac accagcccgg cggcggtcac caccgacccg ctgccaccca
775861 tcgcacggat gatgccggtg ttgattccgg cgtggatctc ctccttgagc cgggcaacca
775921 gcagcaggtt gtagtccgcg ccgacggcca gcaggatgat gaccgccatc gccaacacca
775981 accagtgcag ctcgataccc aggatgtgtt gccagatcag caccgacagc ccgaacgagg
776041 cgcccagcga caacaccacg gtgccgacga tgacggcggc cgcgacgacg ctgcgggtgg
776101 tgatcagcat gatgatgaag atcaggcaga gtgcggagat tccggcgatc atcaagtcat
776161 aggtgttgcc gtcggacaag tccttgaaca tcgccgcggt accgcccagg tagatcgcgg
776221 atccctccaa cggtgtgccc ttgatggctt ccttggcggc ggtcttgatc ttggcgatgc
776281 gcgcgatgcc cgcctggctc atcgggtcgc cttcgtggct gatgatgaac cgcaccgcgt
776341 gcccgtccgg cgagaggaac tgttccaggc cgcgttggaa gtcgggattg tcgaaaacct
776401 cgggaggcag atagaacgag tcgtcgttgc gcgaagcatc aaaggcttcg cccatcgccg
776461 ccgaatcctc ctgcatcgcg gccatctgat cctgcagccc ttcctgggtg gaatgcatgc
776521 tcagcatctg cgccttcatg ctcttcatgg tctggatcat ctcgggcatc atcgcggtca
776581 gctggggcat gagcgtgtcc aggcgctgca tgagcggcag caggttgttg atgtcttcgg
776641 tcatgacgtc gattccgtcg agggtgtcga acaccgaccg cagcgaccag cagaccggga
776701 tgtcgtagca gtgcttttcc cagtagaagt agctgcggat ggggcggaag aaatcgtcga
776761 aatccgcaat atggttgcgc aactcctcga catcgaccac catccccgtc atctgaatga
776821 ccatttcgtg ggtgacatcg gccatctgct gggtgaggct gtgcatccgc tccatctggt
776881 cgatgttgga ctgaatgtcg ttgacctgct ccagcatcct ggccgtcagg tcctggttgt
776941 atttctcggt cagtttctgg ctggtgccct gcatgctgat caggaacggg attgaggtgt
777001 gctcgatcgg tttgccgtcc ggccgggtga tggcctgcac ccgggatatc ccctccacgg
777061 cgaaaatggc cttggcgatc ttgttgatca ccaaaaagtc ggccgaatta cgcatgtcgt
777121 ggtcgctttc gaccatcagc acctcggggt tcatccgggc ctgggagaaa tggcgctccg
777181 cggccgcata gccttcgttg gccggtaggt cggcgggcag gtagttgcgg tcgttgtagt
777241 tggtccggta gcccggcagg gtcagcagac cgacgagcgc cagggccacc gcaccgacca
777301 ggatggggcc gggccagcgg acgatggcgg ccccgacctt gcgccagccc cgcacccgcg
777361 ccatccgctt gggctcgagc agcttgccga accggctcgt cacggcgatt atcgccgggc
777421 ccagggtgag tgcggcggcg acgacgatga ccatcccgat cgccaacggc acaccgaggg
777481 tctgaaagta cggcagtcgg gtgaagctca gacagaacgt ggcacccgcg atggtcagac
777541 ccgagcccag cacgacatgg gcggtgccgc cgaacatggt gtagtacgcc gactcccggt
777601 cctggccgag cccgcgtgct tcctggtagc ggccgatcag gaagatggcg tagtcggtgg
777661 cggccgcgat cgccagcacc acgagcaggt tggtcgcgaa ggtcgagagc ccaatgatcc
777721 ggtggaaacc gaggaaagcc acgcccccgc gggtggcgag cagcccgagc accaccatcg
777781 tcagcatgat cgccgacgtg atgatcgacc ggtagaccag cagcaacatc acgatgatca
777841 cggtgaacgt gaccgcctcg atcacctgca gactacggtc gccggcctgc tgctgatcgg
777901 cgaccagcgc ggccgaaccg gtgacgtaca ccttgacacc gggtggcggc gcaaggcgct
777961 cgacgatggt cttgaccgct tccacggact cgttggccag tgactcgccc tgattgcccg
778021 cgagtttcac ctgaacgtag gcggccttgc cgtcgctgct ctgggcgccg gtggcggtca
778081 gtggatcccc ccaaaagtcc tgcaaggact ggacgtgggt ggtgtcggct tgcagtctgc
778141 cgatcatctg gtcgtaaaac gcatgggcgg cgtcaccgag cggccgctgg ccctccagca
778201 cgatcatcgc cgcgctgtcg gagtctccct cctcgaacac cttgccgatg tgtttcatcg
778261 agatcatcga cggtgccgcg tcggggctca tcgacaccgc ctgtatctgt ccgaccgttt
778321 ccagttgcgg cacagtgacg ttgaggacgg cgatggtgac caaccaccca aggatgatcg
778381 gcaccgcgaa ggtacggatc attctgggga tgaacggtcg cgccgcgtgc ctgtcgggcg
778441 ggacggagcc cgtcggcgca gctgtccttt gcacgatcat gcggatttca caaagcagta
778501 ggtcagggca tccacgccgg ttgcggtccg ctcgtccttc acttcgccat cgacggtgat
778561 tcggcaggtg atggaagtgc cgtcgccttg cgcgaggatg ttgggggccg cggacggcgc
778621 cgtggtcttc aaggtgagcg accacggcag ggctgcgccg tcgatccgct gtggcttggc
778681 gtcgaggtcc aggtagttga tgttgacgta actaccggag ccggaaactt cgtactccac
778741 caccttgggg tcgaacggct ccgggtcatc ggcgaagacc ttcggcgtca ccaagatgcc
778801 ttcggaacca aagaaagtgc ggatccgctg caccgtgaag ccggcgatgg cgaccacaac
778861 caggatgagc agcggtatcc aggcacgctt gagagttcca atcatcgccc tccgcctctg
778921 ccgcatgaag ttcacgccgg tctggtgacg cataccgaac gtcacagatt tcagagtaca
778981 gtgaaacttg tgagcgtcaa cgacggggtc gatcagatgg gcgccgagcc cgacatcatg
779041 gaattcgtcg aacagatggg cggctatttc gagtccagga gtttgactcg gttggcgggt
779101 cgattgttgg gctggctgct ggtgtgtgat cccgagcggc agtcctcgga ggaactggcg
779161 acggcgctgg cggccagcag cggggggatc agcaccaatg cccggatgct gatccaattt
779221 gggttcattg agcggctcgc ggtcgccggg gatcggcgca cctatttccg gttgcggccc
779281 aacgctttcg cggctggcga gcgtgaacgc atccgggcaa tggccgaact gcaggacctg
779341 gctgacgtgg ggctgagggc gctgggcgac gccccgccgc agcgaagccg acggctgcgg
779401 gagatgcggg atctgttggc atatatggag aacgtcgtct ccgacgccct ggggcgatac
779461 agccagcgaa ccggagagga cgactgatga gcaacctcgc aatctgaccg aggtggcgag
779521 caagacggcg attggcctgt ggtcactcct tgttgatgcg gttgcccgcg ccgaggttat
779581 cgattgtggg gtcaccgttt ttgtaggtga ccgtgttgtc cagcccaaca acaacgaggc
779641 gctcgtcgat cctgtcgaag gcgatcttgt tgttcgcacc accgacggtc accgtttcgc
779701 aggtgccgtt gacggtcagc gtgttgtccg agccggccac gttcagtgac ttgccgtcag
779761 cgcagtcaag ggtggcggta gtcccgatgg atccgtaggt cagcatgtca ccgatctgga
779821 tcgaagcggt tgtggattct ccggtcgtca cggtcggcgc cgcggtcggg ccgctcgtcg
779881 ctgtcgtggt ggtggcggtc gcgggcgtcg tggtagctgc cggcgggttg gcagtggaac
779941 tgcagccggc cagcggcaac gctgcggcag ccagcgccag agcaaaggtc gccaaccggg
780001 agtgggtagc gcgatcggcg cgcaacggtt tctcgaccac ctcagccgac ccgctgcagt
780061 cggtttacca ttcctagttc ccggccacgg tcccagatga acggatcacc attgcggaag
780121 aacaccgttt cgtcccagcc gtagacggtg atgtcgttga tgatcgtgtc ggcgacaacg
780181 gtgttggacg agcccatcac ggtcaccgcc cagcaggttc ccagcgcggt cacgatgttc
780241 tgagtgccgt tgaccaacaa ggtggattcg ttgcagtcca gcgtccgctc gatgccctgc
780301 ccggtgacat gggtgtcgcc gttcttggcg tgtgcggccg gcggtggggc ggccaaggcg
780361 acagcgatgg tgatgacacc ggcagccagc gacgcggcga cggtgttcca cttcacggcg
780421 ggcccccctt cgactgggcg ggtgatgctt gactgagcct tggtcgggcc ttgattgagc
780481 gtacgtgcat tcgcccgggc gacgacagac ctgagtgcat ttgccgggca ggcaccccgc
780541 gtctgatgtc agctactcca caacccggtc gctagagtca ttagttggcc ctaacgtccc
780601 ccgaagaccg gtgcggaccc aaagccgatc accccaaccg aagggcgaac cgccatggca
780661 gctcagccgc aagcaccgtc agcgggcggc cgcccgcgcg cggggaaagc ggtgaagtcc
780721 gtggctcgcc cggccaaact gagccgtgag agcatcgtcg agggcgccct gacctttttg
780781 gatcgggagg ggtgggactc gctgaccatc aatgcgctgg cgacccagct cgggaccaag
780841 gggccgtcgc tgtacaacca cgtggacagc ctcgaggatc tacgccgggc ggtgcggatt
780901 cgggtgatcg acgacatcat cacgatgctg aatagggtcg gtgcgggtcg cgcacgcgat
780961 gacgcggtgt tggtcatggc cggtgcctac cgcagctacg cccaccacca cccgggtcgg
781021 tactcggcgt tcacccggat gccgctgggc ggtgacgatc ccgaatacac cgctgcgact
781081 aggggcgcag ccgcgcccgt catcgccgtg ctgtcctcgt acggcctcga cggtgagcag
781141 gctttctacg cggcgctcga gttttggtcg gcactgcatg ggtttgtgtt gctggaaatg
781201 accggcgtca tggacgacat cgataccgat gcggtgttca ccgacatggt gctgcggctg
781261 gcggcgggca tggaaaggcg caccacacac ggtggtaccg cgtcaacgta gcgccctgct
781321 tcggccgcaa cgcccgcttt gacctgccag actggcggcg ggtattgtgg ttgctcgtgc
781381 ctggcggctt acgcttgatg taggggcgtg gatgccgggc caattcgcat gtccgcgatg
781441 cctcggatga gacgaatcga gtttgaggca agctatgcga cacacccggc cgcgggtaac
781501 cgtggcgggg catggccgac aaacagaacg tgaaagcgcc caagatagaa agccggtaga
781561 tgccaaccat ccagcagctg gtccgcaagg gtcgtcggga caagatcagt aaggtcaaga
781621 ccgcggctct gaagggcagc ccgcagcgtc gtggtgtatg cacccgcgtg tacaccacca
781681 ctccgaagaa gccgaactcg gcgcttcgga aggttgcccg cgtgaagttg acgagtcagg
781741 tcgaggtcac ggcgtacatt cccggcgagg gccacaacct gcaggagcac tcgatggtgc
781801 tggtgcgcgg cggccgggtg aaggacctgc ctggtgtgcg ctacaagatc atccgcggtt
781861 cgctggatac gcagggtgtc aagaaccgca aacaggcacg cagccgttac ggcgctaaga
781921 aggagaaggg ctgatgccac gcaaggggcc cgcgcccaag cgtccgttgg tcaacgaccc
781981 ggtctacgga tcgcagttgg tcacccagtt ggtgaacaag gttctgttga aggggaaaaa
782041 atcgctggcc gagcgcattg tttatggtgc gcttgagcaa gctcgcgaca agaccggcac
782101 cgatccggtg atcaccctca agcgggctct cgacaatgtc aaacccgccc tggaggtgcg
782161 cagccgtcgc gtcggcggcg cgacctatca ggtgcctgtc gaggtgcgcc ccgaccggtc
782221 gaccacgctg gcgctgcgct ggctcgtcgg ctactcgcgg caacgccgtg agaagacgat
782281 gatcgagcgc ctggcaaatg agatcctgga tgccagcaat ggccttgggg cctccgtcaa
782341 gcggcgtgag gacacccaca agatggccga ggcgaaccga gcctttgcgc attatcgctg
782401 gtgagaagcg ccggttagcc agccagggcg caaaccgaca gtgatagaca gctaactagc
782461 aaccgaaaga gtgggaagac ttctgtggca cagaaggacg tgctgaccga cctgagtagg
782521 gtccgcaact tcggcatcat ggcgcacatc gatgccggca agaccacaac caccgagcgc
782581 atcctgtact acaccggtat caactacaag attggtgagg tgcacgacgg cgcagccacc
782641 atggactgga tggaacagga acaggagcgc ggcatcacca tcacctctgc ggccacgacc
782701 acgttctgga aagacaacca gctcaatatc atcgacacgc cagggcatgt ggatttcacc
782761 gtcgaggtgg agcgcaatct gcgcgtgctc gacggcgcgg tcgcggtttt cgacggcaaa
782821 gagggtgtcg aaccgcagtc cgaacaggtg tggcggcagg ccgacaaata cgatgtcccc
782881 cgaatctgct tcgtcaacaa gatggacaag atcggtgcgg acttctactt ctcggttcgc
782941 acgatggggg agcggcttgg ggccaacgcc gtgcccattc agcttcccgt cggtgcggag
783001 gccgacttcg aaggcgtcgt cgacctggtg gagatgaacg ccaaggtgtg gcgcggcgag
783061 acgaaactcg gcgaaaccta cgacaccgtg gaaataccgg ccgacctggc cgagcaggct
783121 gaggagtacc ggaccaagct gctcgaggtg gtcgccgagt ccgacgagca cctgttggag
783181 aagtacctgg gcggtgagga gctcaccgtc gacgagatca agggcgcgat ccgcaagctg
783241 acaatcgcca gcgagatcta cccggtgctg tgcggcagcg cgttcaagaa caagggcgtg
783301 cagccgatgc tggatgccgt cgtcgactac ctgccgtcgc cgctggacgt tccgccggcg
783361 atcgggcacg cgcccgccaa ggaggacgag gaggtggtgc gcaaggcgac caccgacgag
783421 ccctttgcgg ccctggcgtt caagatcgct actcacccgt tcttcggcaa gctcacctac
783481 atccgggtgt actcgggcac cgtcgagtcg ggtagccagg tcatcaatgc caccaagggc
783541 aagaaagaac ggctgggcaa gctgttccag atgcactcca acaaggagaa cccggtcgat
783601 agggctagtg ccggtcacat ctacgcggtg atcggtctca aggacaccac caccggtgac
783661 accttgagcg acccgaacca gcagatcgtg ctggagtcga tgaccttccc cgacccggtg
783721 atcgaggtgg ccatcgagcc gaagaccaag agcgaccaag agaagctgag tctgtcgatc
783781 cagaagctcg ccgaagagga tccgaccttc aaggtgcacc tggattccga gaccggccag
783841 accgtcatcg gcggcatggg cgagctgcat ctggacatcc tggtggaccg catgcgccgg
783901 gaattcaagg tcgaggccaa cgtcggcaag cctcaggttg cctacaagga gaccatcaag
783961 cggctcgtgc agaacgtcga gtacacccac aagaagcaga cgggtggctc gggccagttc
784021 gccaaggtca tcatcaacct cgagccgttc accggtgaag agggcgcgac ctacgagttc
784081 gagagcaaag tcaccggcgg gcgtatcccg cgggagtaca tcccgtcggt ggatgccggc
784141 gcacaggacg ccatgcagta cggcgtgctg gccggctatc cgctggtgaa cctgaaggtc
784201 acgctgctcg acggcgccta ccacgaggtt gactcctcgg aaatggcgtt caagatcgcg
784261 ggctcgcagg tgctcaaaaa ggctgccgca cttgcgcagc cggtgatcct ggaaccgatc
784321 atggcggtcg aggtgaccac acccgaggac tacatgggtg acgtgatcgg cgacctgaac
784381 tcccgccgtg gccagatcca ggccatggag gagcgggctg gtgcgcgcgt tgttagggcg
784441 cacgtgccgc tgtcggagat gttcggctac gtcggtgacc ttcggtccaa gactcaaggc
784501 cgggcaaact actccatggt gttcgactcg tactccgaag tgccggcgaa cgtgtcgaag
784561 gaaatcatcg cgaaggcgac gggcgagtga gcgcaagctc acgagtgagg agccgagcaa
784621 tgggtacagc gaaggcgacg ggcgactagg cgatgcgaag acgaccgcta gtgagcgaag
784681 ctcacgagca atgagcagcg cgaaggcgac tggcgagtag atacaaccat acgagtaggc
784741 tggcccggtt acgaccgcgg cataactgaa aacatcaaca ctgcttttat aagcactaac
784801 aagtccagga ggacacaaaa gtggcgaagg cgaagttcca gcggaccaag ccccacgtca
784861 acatcgggac catcggtcac gttgaccacg gcaagaccac cctgaccgcg gctatcacca
784921 aggtcctgca cgacaaattc cccgatctga acgagacgaa ggcattcgac cagatcgaca
784981 acgcccccga ggagcgtcag cgcggtatca ccatcaacat cgcgcacgtg gagtaccaga
785041 ccgacaagcg gcactacgca cacgtcgacg cccctggcca cgccgactac atcaagaaca
785101 tgatcaccgg cgccgcgcag atggacggtg cgatcctggt ggtcgccgcc accgacggcc
785161 cgatgcccca gacccgcgag cacgttctgc tggcgcgtca agtgggtgtg ccctacatcc
785221 tggtagcgct gaacaaggcc gacgcagtgg acgacgagga gctgctcgaa ctcgtcgaga
785281 tggaggtccg cgagctgctg gctgcccagg aattcgacga ggacgccccg gttgtgcggg
785341 tctcggcgct caaggcgctc gagggtgacg cgaagtgggt tgcctctgtc gaggaactga
785401 tgaacgcggt cgacgagtcg attccggacc cggtccgcga gaccgacaag ccgttcctga
785461 tgccggtcga ggacgtcttc accattaccg gccgcggaac cgtggtcacc ggacgtgtgg
785521 agcgcggcgt gatcaacgtg aacgaggaag ttgagatcgt cggcattcgc ccatcgacca
785581 ccaagaccac cgtcaccggt gtggagatgt tccgcaagct gctcgaccag ggccaggcgg
785641 gcgacaacgt tggtttgctg ctgcggggcg tcaagcgcga ggacgtcgag cgtggccagg
785701 ttgtcaccaa gcccggcacc accacgccgc acaccgagtt cgaaggccag gtctacatcc
785761 tgtccaagga cgagggcggc cggcacacgc cgttcttcaa caactaccgt ccgcagttct
785821 acttccgcac caccgacgtg accggtgtgg tgacactgcc ggagggcacc gagatggtga
785881 tgcccggtga caacaccaac atctcggtga agttgatcca gcccgtcgcc atggacgaag
785941 gtctgcgttt cgcgatccgc gagggtggcc gcaccgtggg cgccggccgg gtcaccaaga
786001 tcatcaagta ggtctaccgg ccaccagacg caaaagaaca tgatgggcgc accagcgccc
786061 atcatgttct tttgcgtctg ctcgcgaaaa tgcccagcgt gcggcgctac gctgacatgg
786121 accctccgac gaggcaagga gcaggcacgt gttagcgcgc tacatcaaga tgcagttatt
786181 ggtgctgttg tgcggtggtc tggtcgggcc gatcttcttg gtcgtctact tcacgctcgg
786241 actgggcagc ctgatgtcgt ggatgttcta tgtcggtctg atcattaccg ttgctgacgt
786301 gctggtcgcg ctcgcattga ccaactacgg ggcaaagacc gctgccaaga ccgcggcact
786361 tgaacggagt ggagtgctgg cgctcgccca aatcaccggg ctcagcgaga cagggacccg
786421 gatcaacgat caaccgctgg taaaggtgca cctgcacatc tcgggacccg gcatcactcc
786481 gttcgacacg gaagaccggg tcatcgccag tgtgacccgg ctgggcaatc tcacggctcg
786541 aaaactggtg gtattggtga atcccgccac gcagcaatac ctgatcgact gggaacgaag
786601 cgctttggtc aacggcctgg tgcccgccca attcaccgtc gccgaagaca acaagaccta
786661 cgacttgagt gggcaaaccg gcccgctgat ggagatcttg cagattctga aggcaaacaa
786721 cgttccgctg aaccggatgg ttgacatccg ctcgaatccg gcactgcgtc agcaagtcca
786781 agcggtggtg cggcgggcag ccgagcggca ggcgccggcg gccgagccag cgtcgcaagg
786841 atcgatcgcc gagcggcttg cggagctgga atcgctgcgc gccagcggtg cggtcaacgc
786901 ggcggaatac gagagcaagc gcgcccagat catctccgaa atctgaggcg agctggggca
786961 ccatccgcgg cgagcagacg cgaaagcccg cgacacgccg aggcatcggg ggattttgtc
787021 tggtgggcgg gaatctgggg cacgttagaa cacgttacag tttcgctgct agcctgacag
787081 tcggcgagag gggcgtatgt gtctgcgcgg ggaggatcac tgcacggccg ggtggcattt
787141 gtcaccggcg ccgcccgcgc ccaaggacgg tcgcacgcgg tgcggctggc gcgcgagggg
787201 gccgatatcg tcgcgctgga catctgcgcg ccagtatccg gcagcgtgac ttacccgccg
787261 gccacgtccg aagatctcgg cgagaccgtc cgcgcggtgg aagccgaagg ccgcaaggtg
787321 ctcgcccgcg aggtggatat tcgcgacgac gccgagttgc ggcggctggt ggccgatggt
787381 gtcgagcagt tcggccggct cgacatcgtg gtggccaacg ccggggtgct gggttggggc
787441 aggctctggg aactcaccga tgagcagtgg gagaccgtta tcggggtcaa cttgacgggt
787501 acgtggcgca ccttgcgggc caccgtgccc gcgatgatcg atgccggcaa tgggggttcg
787561 attgtggttg tcagctcgtc ggcggggttg aaggcgacac cgggcaacgg ccactacgcg
787621 gccagcaagc atgcactcgt agcgctgacc aacacgttgg cgatagagct cggtgaattc
787681 ggcatacggg tcaactccat tcatccttac tcggtcgaca ccccgatgat cgaaccggag
787741 gcaatgattc agacgttcgc caagcatccc ggatatgtgc atagctttcc accaatgccg
787801 ttgcagccca aaggttttat gacaccagac gagatatccg acgtcgttgt ctggttggcc
787861 ggcgacggct cgggcgcact gtcgggcaat cagatcccgg tcgataaggg tgccttgaag
787921 tattgacgcg cgatcgtgta tgaacgcaca cgtgaccagt cgtgaaggcg tcaatgagtt
787981 tgacgatgga attgtgatcg tcggcggcgg attggcagct gcgcgcaccg ccgagcagtt
788041 gcgtcgtgcg ggctattcgg gtcgcctcac gatcgtcagc gacgaggtgc atctgccgta
788101 cgaccgtccg ccgctatcca aggaggtgct gcgcagcgag gtcgacgatg tggccctcaa
788161 accccgcgag ttctacgacg aaaaggacat cgcacttcgg ctggggtcgg ctgccgtcag
788221 cttggacacg ggagaacaga cggtaacgct ggccgacggt acggtgctcg gctacgacga
788281 gctcgtcatc gcgactggtt tggtgccccg gcgtattcca tcgcttcccg accttgatgg
788341 cattcgggtg ctccggtcgt tcgacgagag catggcactg cgcaagcatg catccgccgc
788401 acggcacgcc gtggtggtgg gggccggttt catcggctgc gaggtggctg ccagtctgcg
788461 cggtctcggt gtggatgtgg tgctggttga gccgcagccg gcgccgttgg cctcggtgct
788521 gggcgagcag atcggccagt tggtgacgcg gctccatcgc gatgagggcg ttgatgttcg
788581 cacgggtgtg acagtggccg aggtacgtgg caaggggcat gtcgacgcgg tggtcctgac
788641 cgacggtacc gaactgccgg ctgatctggt ggttgtgggc attgggtcga ccccggcgac
788701 cgaatggcta gagggtagcg gcgtcgaggt cgacaacggc gtgatctgtg acaaagccgg
788761 gcggactagc gcgccgaatg tgtgggcgct cggtgacgtc gcctcctggc gagatccgat
788821 gggacaccaa gcacgcgtgg aacattggag caacgtcgcc gaccaggccc gagtcgtggt
788881 gcccgcgatg ctcgggaccg atgtgcccac gggcgtggtc gtcccgtatt tctggagtga
788941 ccagtatgac gtcaaaatcc agtgcctggg ggagccgcac gccaccgacg ttgtgcatct
789001 ggtcgaggac gacgggcgca agttccttgc ctattacgag cgcgatggcg tgctggttgg
789061 cgtggtcggt ggcgggatgg ccggcaaggt catgaaggtg cgcggcaaga tcgccgcggg
789121 cgcgcccatc gccgaagtgt tagaccaaac tcaggcctag agctgaccta ggtggcagcg
789181 ggcgccctgg tcgtcggcgc attcggcgga catatcgtct ggctgtcggg acggctcggc
789241 cagcgcgccg gccgcacgca cccgtgcgac cgccgcgtcg atatcgccac cgtccatatc
789301 ggcacggcgc tcggatgcgg gctgcggccc gctgcaccgg gccatcagat gcacgcccgg
789361 cgcctgccag ccatccgcga cgcggcccgg tttgacggtc caccccagca cgtggcgtag
789421 aagtcgcgga tgacgtcgga atcggctacc tcgtagctga cattcgccgt ttcactgagc
789481 cggcatctgt tgagctctgg gcgtttccgg cacgggctcg gcttcaagac cgcgaatgcc
789541 gcgcttcggt tgtcggtagc atcgaggatg gctccgtgct cggattgacc tgtttgtccc
789601 gcggcgccgc tggctgcggt gatcgcctcg cgcgtggcga ccaggcctgc gacggcctag
789661 cagcaaccag ggtgggacaa ccggagccgg cgaatatgcc ggtcgggagc tcggttgttc
789721 gtgggagctc ggtgaccggc atggggacat gacggcggct gatcgtggtc agccagcttg
789781 tgtcgcgcca cgcagccatg aaatcgcgat tggcggcgga tcgcttccat gcgcggcatc
789841 cgttgcagcc cgaaatgtct ccgacgtcag gtcctcggcc gtgccacggg cgccgcagag
789901 ccgcccatac cgtcgccgcg ctggcgtgaa ttccgacggg ttggtcagga aaatatccgg
789961 cgagctgcta ccgtggcggc gccaacactg tgccgaccca actcggggat cgcagatcgc
790021 tcgtcattgc caggtcaccg gtgggccgtg tggatggcat tcacccaaga cccgggcgtg
790081 accacccggc caactgcgca tacgtaccag gtacttgatt tgggcgccgg gccgctggtg
790141 ggcaggctcc aaggtgaggt gcacgaacgg gcagtgggca tcggcttgcg cggctaatgc
790201 gtcgattccg gcgcggatcg ctgcgcgttc gtcggcgggc aggtactgcc aggtgatcga
790261 atgccacaac acggtgagtg catcgtcggt cagagtcatg ccggcgactg cggcgtgcgc
790321 cgcctgccga tggaggtccg cgggaatgtt gcgggcgacg gcgatggcgc cccgcaaccg
790381 ctccaaccga tcggtctggt ccggccagat gtagctcaac gcgttcagct ccccgtcggg
790441 gctggtgacg tcgatgggcg cgatgtcgta tccgtgtcgt tcgacgatcc gcaccgtggc
790501 cgtcggcggc aattcgccca gccaggcatt gtcgattcgc accggtgagt cggccaggcc
790561 ccattcgccg ccgagataac ggtagcggta ccgatctggt cgcaggttca gccctgcact
790621 ggaccctatc tcgaaaagcc ttattggcaa gtcgaattgg aggcaggcga tgagaagtcc
790681 accgatcaac gccgccgagc gccctacctc gttggtctgc ggtggccgat cgagagccgc
790741 acgcagcgac tccggctggt cggtcgcggt gcggacgata tcgggccagg ctgcctccgc
790801 ctgccaggtg ccgccggtgc tggggtacca gcggcgcaac accggtgcgc ggccgtcgag
790861 caccatccgg tgcaatccgc cgagcagccg aagcggcacc gcctggccct ccggagcacc
790921 cttctggtcg gccaagatgg acgcgaagac gccgccgctt tcgacgtcag ctgccacgag
790981 ctcaagtagc tcgcggtaca tcggggagcc ggaggaggtg cacacccgcc cctgtgaccg
791041 cagggtgtgg accaggtgtt cggtgcccgt cactggttga gtcggtccag accggcgccg
791101 acgacgtcaa acgcggcccc gagcgcttcg gtcaaggaga cggattcgtc gcgcagccaa
791161 tgttcatagg cgctcagagc gacccccagc attgtccagg cgacggtttg gggcataaag
791221 tctgtcgtct ttccacccga tctgcgggca acgaatttgg cgatcacctc gcgccagcca
791281 gcatacatgg tcatcgaata ggcctgcagt tcaggagttt gcaagatgac ccgcatgcgc
791341 ttgcggtgtc ggatggtttc ggattcgtca aaggtgttga aggccaacag cgctgcgcgc
791401 aacgcgtccc tcagctgaat ccgtgaatcg atattgtcga gtagaccttg tagctgtgca
791461 aggtgggtgc tgaagtcacc ccaggggatg gcgttcttgg aggcgtagta gcgaaacaac
791521 gttctgcggg cgatgccggc cgcccgggcg atgtcgtcca cgctgacatc ggtgaaaccg
791581 tgggcagcga acagttcgat ggcaacatcg ctgatgtggt gcggtgtggt tgagcgccgt
791641 cggcccaccc gcgactcgtg cggcatcaca ttcgcccttc catttcggca ctcgatgcca
791701 tattgtgtcc agatcgacgg atcgctgtcg agacctgctg gcgaaaggca atccagatgg
791761 actacgaaac cgataccgac accgagcttg tcaccgagac cctggttgaa gaggtgtcca
791821 tcgacggaat gtgtggggtt tactgaccgt gccggcgccc gcgcaggctc gccgggctga
791881 ttccagcgaa ttcgatcccg atcgcggctg gcgactacac ccacaggtgg cggtccggcc
791941 ggagcctttt ggcgcgctgc tctatcactt cggcacccgt aagttgtcat ttctgaaaaa
792001 tcgcaccatc ctcgcggtgg tgcagacgct ggcggattat cccgatatcc ggtcggcctg
792061 ccgcggcgcc ggcgtcgacg actgtgacca ggatccgtac ctgcacgccc tgagtgtgct
792121 cgccggttcg aacatgctgg ttcctcggca gacaacatga cgagccccgt accccgactc
792181 atcgagcagt tcgagcgggg gctcgacgcg ccgatctgcc ttacctggga gctgacctac
792241 gcctgcaacc tagcttgcgt gcactgcctg tcgtcctcgg gcaaacgcga tcccggcgag
792301 ttgtccaccc gccaatgcaa ggacatcatc gacgaactgg aacgcatgca ggtgttctac
792361 gtgaacatcg gcggcggcga accaaccgtg cgcccggact tttgggagct ggtagattac
792421 gccaccgcac accacgtcgg ggtgaaattc tccaccaacg gggtccggat cacccccgag
792481 gtggccacgc ggctggcagc caccgactac gtcgacgttc agatctcact cgacggcgcc
792541 acggccgagg tcaacgacgc catccgcggc accgggtcgt tcgacatggc ggtgcgcgcg
792601 ctgcagaacc tggcagcggc gggatttgcc ggcgtcaaga tctcggttgt gatcacccgg
792661 cgcaacgtcg cccagctcga cgaattcgcc acgctggcaa gccgttacgg agcgacgttg
792721 cggataacca ggttgcgacc gtccgggcgc gggactgacg tatgggccga cctgcacccc
792781 accgccgacc agcaggtgca gctttacgac tggctggttt ccaaaggaga gcgggtgctc
792841 accggcgatt ccttcttcca cctggcgccg ctcggccagt cgggggctct ggccggcttg
792901 aacatgtgcg gagccgggcg ggtagtgtgc ctgatcgacc cggtgggtga cgtgtatgcg
792961 tgcccattcg ccattcatga ccacttctta gccggaaacg tgttgtccga cggcggattt
793021 caaaatgtct ggaagaactc gtcgctgttt cgcgagctcc gggagcccca gtccgcaggc
793081 gcctgtggca gctgcggaca ctacgacagc tgccggggcg gctgcatggc ggcgaaattc
793141 ttcaccggcc tgccgctgga cgggccggat cccgaatgcg tgcaaggcca tagcgagccg
793201 gcgctggcgc gcgagcgcca cctaccgcgg ccccgcgccg accactcccg cggtcggcgc
793261 gtcagcaaac cggtgcccct gacgctgtcg atgcggccac ccaagcgccc gtgcaatgaa
793321 agtccggtgt agccgtggcc gaagcgtggt ttgaaacggt agccatcgcg cagcaacgcg
793381 cgaagcggag gctgccgaaa tcggtttact cgtccctgat tgcggccagt gaaaagggaa
793441 tcacggtcgc cgacaatgtc gcagcattca gcgagctcgg gttcgcgccg cacgtcatcg
793501 gggcgacaga taaacgtgac ttgtcgacga ccgttatggg gcaagaagtt tcgttgccag
793561 tgattatttc gccgaccggt gttcaggcgg tcgatcccgg cggtgaagtc gccgtcgcgc
793621 gggccgcggc cgcccggggt actgtgatgg gattgtcctc gtttgccagc aagccgatcg
793681 aggaggtcat tgccgccaac cccaagacct tcttccaggt ctactggcag ggcgggcgcg
793741 acgcgctcgc tgaacgcgtc gaacgggcgc ggcaggccgg cgcggtcggc ctggtcgtca
793801 ccaccgactg gacgttctcg cacgggcgcg actggggcag ccccaagatc cccgaagaga
793861 tgaacttgaa gaccatcctg cggctatccc cggaggcgat cacccggccg aggtggttgt
793921 ggaagttcgc caagacgcta cggccaccgg acctacgggt gcccaaccag ggccggcgcg
793981 gcgagcccgg cccaccgttc ttcgcagcct acggcgaatg gatggcaaca cctccgccga
794041 cctgggaaga tatcggctgg ctgcgcgaac tgtggggcgg accgttcatg ctcaagggcg
794101 tcatgcgggt cgacgatgcc aaaagagctg tggatgccgg ggtttcggcg atctcggtat
794161 ccaaccatgg tggcaacaat ttggatggga cgccagcatc gatccgggcc ctgcccgcgg
794221 tctcggcggc ggtcggcgat caggtcgaag tgttgctcga cggcggcatc cggcggggca
794281 gcgatgtcgt caaggcggtg gcgctgggcg cgcgcgcggt aatgattggt cgcgcttacc
794341 tgtggggctt ggccgccaac ggccaagccg gggtcgagaa tgtactcgac atcctgcgcg
794401 gtggtatcga ctcggctctg atgggtctcg ggcatgcctc tgtccatgac ctcagcccag
794461 ccgacatcct cgttcccacc gggttcatcc gcgacctggg tgtgccctcc cgacgggacg
794521 tttagccgga tgttgagctg ggcccaaatt ggggttggcc ctcccattac cacagagatg
794581 ctcgcgacgg aatgacgttt ttagaaattc tgatacgggc gtggcagccg tggcgggcga
794641 gcaggatgtg tggccggtaa gtcatcacga cgaaaaaaat ttcggtagaa gacataacaa
794701 ttggtgcacg ccaggtgaat tcgtcctacc atcggcgagt gccggtagtc ggggaactcg
794761 ggagtgcgac gtcgagccag ctaccaagca cgtcgccgtc gatagtgatc ccgctggggt
794821 ccaccgagca gcacggtccc cacctgccgt tagataccga tacccggatc gcgaccgccg
794881 tggcccggac cgtcaccgcg aggctgcacg ccgaggacct gcccattgct caggaggaat
794941 ggctgatggc gcccgccatt gcctacggcg ccagcggcga acaccagcgt ttcgctggaa
795001 cgatctctat cggcactgaa gccctgacga tgttgctcgt ggagtatggc aggtcggccg
795061 cctgctgggc ccggcgcctg gtcttcgtca acgggcacgg cggcaatgtc ggcgctttga
795121 cccgagcggt aggcctgctg cgcgctgaag gtcgcgacgc cggatggtgc ccgtgcacct
795181 gcccgggcgg tgacccccac gccggccaca ccgaaacatc cgtgctgctg catctttcgc
795241 cggccgacgt gcgcaccgaa cggtggcgcg cgggtaatcg cgcaccgctg cccgtgttgt
795301 tgccgtcgat gcgccgaggc ggggtcgcgg ccgtgagcga gacaggagtg ctcggggatc
795361 cgaccacggc gaccgcggcc gaggggcggc ggatcttcgc ggcgatggtc gacgactgtg
795421 tgcgccgagt cgcccggtgg atgccacagc ccgacgggat gttgacatga ccgcgccggc
795481 gacgatgcag agcgaagcga tgaggagaag cggcgcagat gaccgcgacc cgactgcctg
795541 acgggttcgc cgtccaggtt gaccgtcgcg tgcgagtgct tggcgacggc tcggccctgc
795601 tcggtggctc accgacccgg ttgctgcggc tggctcccgc cgcacgaggc ctgctctgtg
795661 acggccgcct taaggtccgc gacgaggtca gcgcggagct ggcccgcatc ctgctggacg
795721 ccacggtggc gcatccacgg ccgccgagtg ggccgtcaca tcgtgacgtc accgtcgtta
795781 taccagtacg gaacaacgca tctggtctgc ggcgtctggt gacctcgtta cgcggattac
795841 gcgtcatcgt ggtcgacgac ggttcggcgt gcccggtcga gtcggacgac tttgtcggcg
795901 cacattgcga catcgaagta ctccaccacc cccacagcaa ggggccggcc gcggctcgca
795961 acaccgggct agcggcctgc accaccgact tcgtggcgtt cctggattcc gacgtgacgc
796021 cgcggcgggg atggttggaa tccttactcg gccacttctg cgatcccacc gtcgcactcg
796081 tcgcacctcg catcgtcagc ttggtggaag gcgagaaccc ggtagctcgc tatgaggccc
796141 tgcactcgtc gttggacctt ggtcagcgcg aagcgccggt gttaccgcat agcacagtct
796201 cttacgtgcc gagcgccgcc atcgtttgcc ggagttcagc catccgcgac gtcggcggct
796261 tcgacgagac catgcactcc ggggaagatg tcgacttgtg ctggcggctc atcgaggctg
796321 gtgctcggct gcgctacgag ccaattgcgc tggtcgccca tgaccatcgg acccaattgc
796381 gggactggat cgcgcgcaag gcgttttacg gcggttcggc ggctccgcta gctgtgcggc
796441 acccggacaa gaccgcgccg ctggtgattt cgggcggggc gctgatggcg tggatcctca
796501 tgtcgatcgg cacaggcctt ggtcgactgg cgtcgttggt gatcgcggtg ctgactggtc
796561 gccggatcgc cagggccatg cgctgcgccg agacgtcgtt cttggatgtg cttgccgtcg
796621 ccacccgcgg gttgtgggcg gccgcgctgc agctggcgtc ggccatctgc cggcactatt
796681 ggccactggc attgctcgcg gccatcctgt cgcgccgctg taggcgggtg gtgttgattg
796741 cggcggtagt ggacggtgtg gtggattggc ttcgccgcag ggagggcgcc gacgatgatg
796801 ctgaaccgat tgggccgctg acctacctag tgctgaagcg cgtggacgac ttggcttatg
796861 gcgctggcct gtggtacggg gtggtgcgcg aacgtaacat cggcgcgctc aagccgcaga
796921 ttcgtaccta gtgtgactgc ggcggtccgg catagcgatg tgctggtcgt cggtgctgga
796981 agtgctggat cggttgttgc cgagcgtctt tccatggact cgagctgtgt ggtgaccgtg
797041 cttgaggctg gccccgggct ggccgatccg gggttgctgg ctcagacggc caatgggttg
797101 caactgccga tcggagctgg cagccctctg gttgagcgtt atcggacgcg gctcaccgat
797161 cgaccggttc gccacttgcc gatcgtgcgg ggtgcgacgg tcggcggttc cggcgcaatc
797221 aacggcggct atttctgccg cggactgccc agcgatttcg accgtgcctc gataccaggc
797281 tgggcatggt ctgacgttct ggagcacttc cgggctatcg agacagatct ggatttcgag
797341 acgcctgtgc atggccgtag tggccccatc ccagttcgcc gcacacacga aatgactggc
797401 atcactgaaa gtttcatggc tgccgcagag gacgcagggt tcgcttggat cgctgacctc
797461 aacgatgttg ggccggaaat gccttcgggt gtaggcgcgg tcccgctcaa catcgttaac
797521 ggcgtacgca ccagctcggc ggtcggctat ctgatgcccg cgctgggacg gccgaatctg
797581 acactgctgg cccggacgcg ggcggtgcgg ttgcgctttt ccgccaccac cgcggtgggt
797641 gtcgacgcga tcggcccagg aggcccggta agcctgagcg ctgaccgaat cgtattgtgc
797701 gccggagcga ttcagtcagc tcatctgttg atgctctcgg gcgtcggcga ggaggaggtg
797761 ttgcgatccg ccggtgtgaa ggtgcttatg gcgttgccgg ttggcatggg ctgcagtgac
797821 cacccggaat gggtgatgcc gaccaactgg gcggtggctg tcgatcggcc ggtgttagag
797881 gtgctgctga gcactcatga cggcatcgaa ataaggccgt acacaggcgg cttcgttgcg
797941 atgaccggcg acggtacagc cgggcatcgc gattggccgc atatcggggt ggcgctcatg
798001 cagccgcggg cacgcggacg catcacgttg gtctcgagtg atccccagat accagtccgc
798061 atcgagcacc gatacgacag tgaacctgcc gatgtcgcgg ccctgcgcca gggtagcgca
798121 ttggcccacg aattatgcgg tgcggcaacg cgcatcggtc cagccgtatg ggcgacatcg
798181 cagcatctgt gtggtagtgc cccaatgggc accgacgatg acccacgagc cgtcgtcgac
798241 ccgaggtgtc gggtccgcgg catcgaaaac ctatgggtga tagacggatc tgtccttccg
798301 tcgatcacca gtcgcggtcc acacgcaacg atcgtaatgc tgggccaccg cgcggccgaa
798361 tttgttcagt gactttcgtc gagtggggcg accacagcgg tcgctgccga atgtgcattt
798421 cggtcaggca ttgagcaggg gaccgaatag cgtagctccg catcggactg cagtcgtcag
798481 gtcgacgatg atggcgctga catcggaggt gggccgcggc ccaggcttcg cggtttggcg
798541 gcctgcgaag aagtggctct tctgacactt ccgtgggtgg acttctggtt tgagtaggcg
798601 cacgtcgttg tcgcttaggg tttctggctt gtcaaaggac aggaccagcg cagatcactg
798661 tagtcttagc tgatgctgcc gcccggattg ccgacgtcgt ggcccagcgg tgccccaacg
798721 cggtccgccg cgtcgatcct ttccacgtgg tggcctgggc caccgaggct ctagaggctg
798781 aacggcgccg ggcctgaaac gacgcgcgag cgcccgcccg gaccccgagt cattgggtcg
798841 caggggtaac cgaagggtgc acgttgaccg cgtgaggcta accggcaccg agcgtgaact
798901 gagggcggag aatcagagcc ccccgatttt ccgcccgcag aacacgttgg gcgacggcgc
798961 caacgggctg ccactggccg tgtgcaccac gacggctcac acgtgccaca cttcccatac
799021 tcacccatcg cggtggaccc caaacccagt gccggccacc aagggcgtcc ccgctggatt
799081 ggtgcaagca accttcatca tcgaaaacct tgaccccggc aacaacgaca cgccgacccc
799141 ccctacaccc aaactgcgat tagcccgaaa acctgggcac cataggcgat ctgaatacga
799201 tgcggattcg gtgctgcgga gaaaggatac atcgcgccga tgcgtccagg cggatgacgt
799261 ccgatgcgtg cagctggtcc aggatccgcg gcgcggacgt gtcgaactcg gtggttaccg
799321 cgccgagctt actgttggcc gacgggcggc ggtgaattgc caacgcccgc aatatggtgc
799381 ggatggatgg cccgttcggt tgggttgcgg ggtaggcggc gccgcgcgag gcgatcagcg
799441 ctgaggtcgg gaattcacct ccggtcgcgg gagtacagcg gtcggctggg gtgccgccgg
799501 tgtctgtcgg gtagaggcgg caggacacgc tcgccgtcaa aacggcttcg gcaaacgggt
799561 cttcgccgtc gacaggcagg gttggtgatc ccggcctcgg cggcgacggt ctggtcattg
799621 attgtgcgat gggtgatcgt cgtgtcgatc tgctcgcggc gaaggactcg gagatccggc
799681 gctcgatggg ggcagtaccg gtcggcgcgg gaagctcgca ggtggcgacg agttgggcga
799741 gtgatcgttg catccgctgt cgggcggcga ttctgtcggc cgactgtgcc aacttggcta
799801 gggccaattc gcggggcggt ctggcagtcg gcgggtccgc tgtcagctag ctgcagcagc
799861 tcctcgatct cgtcgaggct gaatccatgg gactacgcgc gtctgacgga cgagaccacc
799921 gataccgcat cggcgcgata ccgcgatagc cctgagaacg accgggccgg cgcggctagc
799981 aggtcctccg ctcgtaatag cgcagcgtct ggccgttgat cccagcccgc gcggcaacct
800041 ggctactccg cattccgcca ttccgaaccc tgtactcgac tgtcgagtca agggtgtgtg
800101 ttgtcagtgc cgggtcaggt gccgatagca accggccgcc cgccgctgca cccgagccag
800161 cggcgatttg gccgaagcgg tgatctgggg catactgttc aggttgccct gcgccaggtt
800221 tgcgtctggc cgggcatacg accagcgccc acacgggcgc gtccggtccc acccttgaag
800281 cgcgacgatt tcggccttga aattgatcgc gacaaggctg tgtgcgggcg acacgcccga
800341 gcgcggggcc ggtggaccta cgacaggtaa acagcggcgc agtattcggc gcaacgctag
800401 atcggtccag aaggaccggg tcgatcggcg cgccggggag caccggaccc ggatacgggc
800461 tcgagtggga gtgaggtagg agaagcgtgg cgggacagaa gatccgcatc aggctgaagg
800521 cctacgacca tgaggccatt gacgcttcgg cgcgcaagat cgtcgaaacc gtcgtccgca
800581 ccggtgccag cgtcgtaggg ccggtgccgc taccgactga gaagaacgtg tattgcgtca
800641 tccgctcacc gcataagtac aaggactcgc gggagcactt cgagatgcgc acacacaagc
800701 ggttgatcga catcatcgat cccacgccga agaccgttga cgcgctcatg cgcatcgacc
800761 ttccggccag cgtcgacgtc aacatccagt aggagattgg acagagcaat ggcacgaaag
800821 ggcattctcg gtaccaagct gggtatgacg caggtattcg acgaaagcaa cagagtagta
800881 ccggtgaccg tggtcaaggc cgggcccaac gtggtaaccc gcatccgcac gcccgaacgc
800941 gacggttata gcgccgtgca gctggcctat ggcgagatca gcccacgcaa ggtcaacaag
801001 ccgctgacag gtcagtacac cgccgccggc gtcaacccac gccgatacct ggcggagctg
801061 cggctggacg actcggatgc cgcgaccgag taccaggttg ggcaagagtt gaccgcggag
801121 atcttcgccg atggcagcta cgtcgatgtg acgggtacct ccaagggcaa aggtttcgcc
801181 ggcaccatga agcggcacgg cttccgcggt cagggcgcca gtcacggtgc ccaggcggtg
801241 caccgccgtc cgggctccat cggcggatgt gccacgccgg cgcgggtgtt caagggcacc
801301 cggatggccg ggcggatggg caatgaccgg gtgaccgttc ttaacctttt ggtgcataag
801361 gtcgatgccg agaacggcgt gctgctgatc aagggtgcgg ttcctggccg caccggtgga
801421 ctggtcatgg tccgcagtgc gatcaaacga ggtgagaagt gatggctgcg caagagcaga
801481 agacactcaa aatcgacgtc aagacgccgg cgggcaaggt cgacggcgct atcgagctgc
801541 cggccgagct gttcgacgtc ccggccaaca tcgcgctgat gcaccaggtg gtcaccgccc
801601 agcgggcggc ggcacgccag ggtacccact cgacgaagac gcgcggcgag gtcagtggcg
801661 gtggccgcaa gccctaccgg cagaagggga ccggtcgtgc ccggcagggc tcgacgcggg
801721 cgccgcagtt caccggcggt ggcgtggtac acggtcccaa gccgcgcgac tacagccagc
801781 gcacacccaa gaagatgatc gccgcggcgc tgcgcggggc gctgtccgac cgggcccgca
801841 acgggcgtat ccacgcgatc accgagctag tggaaggtca aaacccgtcg accaagagcg
801901 ccagggcatt tctggccagc ctgacagaac gtaaacaggt gctggtggtc atcgggcgca
801961 gcgacgaggc cggcgcgaaa agcgtgcgca atctgccggg cgtgcacatc ctggcgccgg
802021 accagctcaa cacctatgac gtgctgcgtg ccgacgacgt ggtgttcagc gttgaggcgc
802081 tgaatgccta tatcgcggcc aacaccacga cgtccgagga ggtttcggcc tgatggcgac
802141 gctcgctgac ccccgcgaca tcatcctggc cccggtgatc tcggagaaat cctatgggtt
802201 gctggatgac aacgtgtaca cgtttttggt gcgcccggat tccaacaaga cgcagatcaa
802261 gatcgccgtc gagaagattt ttgccgtcaa ggtcgcatcg gtgaacaccg cgaaccggca
802321 gggcaagcgt aaacgcaccc ggaccggata cggcaagcgc aagagcacca agcgcgccat
802381 cgtcaccctg gcgccgggca gcaggccgat cgacctgttc ggggcaccgg cctagcccgg
802441 cgacgatgca gagcgaagcg atgaggagga gcagggcaat gcggcctagc ccggcgacga
802501 gagcgtgaga gaaagacctg attagacatg gcaattcgca agtacaagcc cacgacgcct
802561 ggtcgtcgcg gcgccagcgt atctgatttc gccgagatca cccggtcaac cccggagaag
802621 tcgctggtgc gcccgctgca cggtcgcggt ggacgcaacg cgcatggccg gattaccacc
802681 cggcacaaag gcggcggtca taagcgcgct taccggatga tcgactttcg ccgcaatgac
802741 aaagatggtg tcaacgccaa ggtcgcgcac atcgagtacg acccgaaccg taccgcacgg
802801 attgcgttgc tccactatct cgatggggag aagcgctaca tcattgcacc caacggactt
802861 tcgcaagggg atgtggtgga atccggcgct aacgccgaca tcaagccggg caacaacctg
802921 ccattgcgca acatcccggc cggtaccttg atccacgccg tggagctccg cccgggaggt
802981 ggcgctaagc ttgcgcgctc ggccgggtcg agcatccagc tgctcggcaa ggaggccagc
803041 tacgcgtcgc tgcgtatgcc cagcggtgag atccgccggg tcgacgtccg ctgccgcgcg
803101 accgtcggcg aagtgggcaa tgccgagcag gcaaacatca actggggcaa ggccggtcgg
803161 atgcggtgga agggcaagcg cccgtcggtc cggggcgtgg tgatgaaccc ggtcgaccac
803221 ccgcacggcg gtggtgaggg taagacctcc ggcggccgtc acccggttag cccgtggggc
803281 aagcctgagg ggcgtacccg caatgcgaac aagtcgagca acaagttcat cgtccgacgc
803341 cggcgcaccg gcaagaagca ctcgcgttag ccgcgcaatc agatctaggg agtttcagga
803401 gtagccaacc atgccacgca gcctgaagaa gggcccgttc gtcgacgagc atctgctcaa
803461 gaaggtcgat gtccagaacg agaagaacac caagcaggtc atcaagacct ggtcgcgtcg
803521 gtcgaccatc attccggact tcatcggcca tacctttgcg gtgcacgacg gccgcaagca
803581 cgtccccgtg ttcgtcaccg aatcgatggt gggccacaaa cttggtgagt tcgcgccgac
803641 acgcaccttc aagggccaca ttaaagacga ccgaaagagc aagcggcgat gactgcggct
803701 actaaggcta ccgagtatcc ctcggcggtc gccaaggccc gatttgtgcg ggtgtcgcca
803761 agaaaggcgc gccgggtgat cgatctggtg cgtggcaggt cggtgtcaga cgcgctcgac
803821 atcctgcgct gggcgccgca ggccgccagc ggtccggtgg ccaaagtgat cgccagtgcg
803881 gcggccaacg cgcaaaacaa cggcgggctg gacccggcaa ccttggtggt ggccaccgtg
803941 tacgccgacc agggaccgac cgccaagcgc atccgtccgc gcgcccaggg ccgcgcgttc
804001 cgcatccgcc ggcgcactag ccacatcacg gtggtggtgg aaagccggcc ggccaaagat
804061 caacggtcgg cgaaatcgtc gcgggcccgc cgcaccgagg ccagcaaggc cgccagcaag
804121 gtcggggcta cggcgccggc caagaaagcg gccgccaaag cgcccgccaa gaaggcaccc
804181 gccagttccg gcgttaagaa gacacccgca aagaaagcgc ccgccaagaa ggcgcccgcc
804241 aaggcttctg agacttctgc agcgaaggga ggctcagact agtgggccaa aagatcaatc
804301 cgcatggctt ccggctgggc atcaccaccg actggaagtc gcgctggtat gccgacaagc
804361 agtatgccga gtacgtcaag gaggacgtgg cgatccgccg gctgctgtcc agtggcctag
804421 agcgtgctgg gatcgccgat gtagagatcg agcggacccg cgaccgggtc cgggtggaca
804481 ttcacaccgc gcgtccgggc atcgtcattg gtcggcgtgg gaccgaggcc gaccggattc
804541 gtgccgacct ggaaaagctg accggcaagc aggtccagct caacatcctg gaggtcaaaa
804601 acccggagtc gcaagcgcaa ttagtggccc agggggtagc cgagcagttg agcaaccggg
804661 tggcgttccg ccgcgcaatg cgcaaggcga tccagtcggc gatgcgtcag cccaacgtca
804721 agggaatccg ggtgcagtgc tcgggccgcc tcggcggcgc ggaaatgagc cgctcggagt
804781 tctaccgcga gggccgcgtc ccgctgcaca ccttgcgggc agatatcgac tacggcctat
804841 acgaggccaa gaccaccttc ggccggatcg gtgtgaaggt gtggatctac aagggtgaca
804901 tcgtgggcgg caaacgtgaa ttggctgccg ccgcgccagc gggcgccgac cgtccgcgcc
804961 gtgagcggcc gtcgggcacg cgcccccgtc gcagcggtgc ttcgggcacc acggcgaccg
805021 gtaccgacgc gggtcgggcc gcgggtggcg aagaggccgc gcctgacgcc gcagcgcccg
805081 ttgaagcgca gagcacggag agctgaatca tgttgattcc ccgtaaggtt aaacatcgca
805141 agcagcacca tcctcgccag cgcggcatcg ccagcggcgg caccacggtg aacttcggcg
805201 actacggcat tcaggccctt gagcacgcct atgtcaccaa ccggcagatc gaatcggcgc
805261 gtatcgccat caaccggcac atcaagcgtg gcggcaaggt ttggatcaac atcttccctg
805321 accgcccgct gaccaagaag cccgccgaaa cccgcatggg ttcgggcaag ggctcgccgg
805381 agtggtgggt agccaacgtt aagccgggcc gggtgctgtt cgagctcagt taccccaatg
805441 aaggtgtcgc ccgggccgcg ctcacccgag cgatccacaa gctgccgatc aaggcacgca
805501 ttattactcg agaggagcag ttctgatggc agtgggtgtc tcgccgggcg aactgcgtga
805561 gctcaccgac gaggagctgg ccgagcggtt gcgcgagtcc aaggaagagt tgttcaactt
805621 gcgtttccag atggcgaccg gccagctcaa caataaccgc cggctccgta cggtgcgtca
805681 ggaaatcgcg cgcatctaca ccgtgctgcg cgaacgagaa ctgggtctgg cgactgggcc
805741 cgatggtaag gaatcgtgat ggcagaggct aagaccggcg cgaaggcggc gcctagggtg
805801 gctaaggccg ccaaggcggc ccccaagaag gccgcaccca acgacgctga ggccataggt
805861 gcggccaacg cggcaaacgt taaggggccc aagcacactc cgcgtactcc gaagccacgc
805921 ggccgccgca agacacgaat cggctatgtg gtgagcgaca aaatgcagaa gaccattgtg
805981 gtggagctgg aagaccgcat gcggcacccg ctatacggca agatcatccg gaccactaag
806041 aaggtcaagg cacacgacga agacagcgtt gccggcattg gcgaccgtgt ctcgctgatg
806101 gagacgcgtc cgctgtcggc gaccaagcgc tggcggctcg tcgagatcct cgagaaggct
806161 aagtaagcct gacgagcagt cgcaaaagcc cccgacacgc gcggcgtgcg ggggcttttg
806221 cgactgctcg cccaaccagc gcggcgtcag tgcggaaatc ctcagctgat tcctaccctg
806281 tgcgtgtagt gtacacaacc gttcattaac tccacgggga agtgaggctg gcttatggca
806341 cccgaggcca ccgaggcgtt caacggcacc atcgagctgg atattcgtga ttcggagccg
806401 gattggggcc catacgcagc gccggtggca ccggagcact caccaaacat cctgtatctg
806461 gtctgggacg acgtcggcat cgcgacctgg gactgctttg gcggcctggt cgagatgccc
806521 gcgatgacgc gcgtcgccga gcgtggcgtg cgactgtcgc aatttcacac caccgcactg
806581 tgctcgccga cccgggcgtc gctgctgacc ggtcgcaacg ccaccaccgt aggcatggct
806641 accatcgaag agttcaccga cgggttcccc aactgcaacg ggcggatccc ggctgacacc
806701 gcgttgctcc cagaggtgct ggccgaacat ggctacaaca cctactgtgt gggcaagtgg
806761 cacctgacgc cactcgaaga atccaatatg gcgtcgacga agcggcactg gccgacctcg
806821 cgtgggttcg agcggttcta cggattccta ggcggggaga ccgaccagtg gtatcccgac
806881 ctggtatacg acaaccaccc agtgagtcct cccggcacac ccgagggtgg ctaccacctg
806941 tcaaaagaca tcgccgacaa gacgatcgag ttcattcgtg atgccaaggt gatcgcgccc
807001 gacaagccgt ggttcagcta cgtgtgccca ggcgccgggc atgcgccgca ccacgtcttc
807061 aaggaatggg cggacagata cgccggccga ttcgacatgg ggtatgagcg ctatcgcgag
807121 atcgtgctgg aaaggcaaaa ggcgctaggg atcgtgccac ccgacaccga actgtcgccc
807181 ataaaccctt atctggatgt gccggggcca aacggcgaga cctggccgct gcaggacacg
807241 gtgcggccgt gggactcgct gagcgatgaa gaaaagaagc tgttttgccg gatggccgag
807301 gtgttcgccg gctttctgag ctacaccgac gcccagatcg gacggatcct ggactacctc
807361 gaggaatccg gccagctgga caacaccatc atcgtggtga tctccgacaa cggcgccagc
807421 ggcgagggcg gacccaacgg atcggtcaac gaaggcaagt tcttcaacgg ctacatcgac
807481 accgtcgctg aaagcatgaa gctcttcgac cacctcggtg gcccgcagac ctacaaccac
807541 taccccatcg ggtgggcaat ggccttcaac accccctaca agctgttcaa gcgctacgcc
807601 tcgcatgaag gcggcattgc cgacccggca atcatctcct ggcccaacgg cattgccgca
807661 cacggtgaaa tccgcgacaa ctacgtcaat gtcagcgaca tcacgcccac cgtctacgac
807721 ctgttgggca tgacaccgcc ggggaccgtc aaggggattc cgcagaaacc gatggacggc
807781 gtgagcttca tagcggccct tgccgacccg gccgccgaca ccggcaagac cacccagttc
807841 tacaccatgc tgggcacccg cgggatctgg catgaaggtt ggttcgccaa caccattcac
807901 gcggccacgc ccgccggctg gtcgaatttc aacgctgacc gctgggaact gttccacatc
807961 gcagcagacc gcagccagtg ccacgacctg gccgccgagc atcccgacaa acttgaggag
808021 ctcaaggcgc tgtggttctc cgaagccgcc aagtacaacg ggctgccgct ggccgatctg
808081 aacctcctgg aaacgatgac tcggtcgcgg ccttacctgg tcagcgaacg agccagctac
808141 gtctactatc ccgactgcgc tgacgtcggc atcggcgcgg ccgtagagat tcgcgggcgc
808201 tcgttcgccg tgctggccga tgtgaccatc gataccaccg gcgccgaggg cgtgctgttc
808261 aagcacggcg gcgcccatgg cgggcacgtg ctgttcgtcc gggacggacg cttgcactac
808321 gtctacaact tcctcggtga gcgccagcag ctggtcagct cgtcgggtcc ggtcccgtcg
808381 ggaagacatc tactcggggt tcgttatttg cggaccggaa ccgtgcccaa cagtcacacg
808441 ccggtgggcg atcttgagct gttcttcgac gagaacctgg tcggcgccct gaccaatgtg
808501 ctgacccacc ctggaacgtt cgggttggcc ggcgccgcta tcagcgttgg ccgcaacggc
808561 ggttcggctg tgtccagcca ctacgaagcg ccgttcgcgt tcaccggcgg taccatcacc
808621 caggtcaccg tcgacgtgtc aggccgaccg ttcgaagatg tggaatccga tcttgcgctt
808681 gctttttcgc gtgactgagc ggtctgctgt gacgcgggac ggcgtggtcg gcatacgctg
808741 aagtcgtgct gaccgagttg gttgacctgc ccggcggatc gttccgcatg ggctcgacgc
808801 gcttctaccc cgaagaagcg ccgattcata ccgtgaccgt gcgcgccttt gcggtagagc
808861 gacacccggt gaccaacgcg caatttgccg aattcgtctc cgcgacaggc tatgtgacgg
808921 ttgcagaaca accccttgac cccgggctct acccaggagt ggacgcagca gacctgtgtc
808981 ccggtgcgat ggtgttttgt ccgacggccg ggccggtcga cctgcgtgac tggcggcaat
809041 ggtgggactg ggtacctggc gcctgctggc gccatccgtt tggccgggac agcgatatcg
809101 ccgaccgagc cggccacccg gtcgtacagg tggcctatcc ggacgccgtg gcctacgcac
809161 gatgggctgg tcgacgccta ccgaccgagg ccgagtggga gtacgcggcc cgtggcggaa
809221 ccacggcaac ctatgcgtgg ggcgaccagg agaagccggg gggcatgctc atggcgaaca
809281 cctggcaggg ccggtttcct taccgcaacg acggtgcatt gggctgggtg ggaacctccc
809341 cggtgggcag gtttccggcc aacgggtttg gcttgctcga catgatcgga aacgtttggg
809401 agtggaccac caccgagttc tatccacacc atcgcatcga tccaccctcg acggcctgct
809461 gcgcaccggt caagctcgct acagccgccg acccgacgat cagccagacc ctcaagggcg
809521 gctcgcacct gtgcgcgccg gagtactgcc accgctaccg cccggcggcg cgctcgccgc
809581 agtcgcagga caccgcgacc acccatatcg ggttccggtg cgtggccgac ccggtgtccg
809641 ggtagtgcca acttcgcatg aggaactgca cacccagcag ggcgtcagtc ggcgcgacga
809701 gtcactcccg ggggctacgc atgaattcga ctaccggagc gggcctggct gggcgtgggc
809761 gcgcgcagtt gtacggcccc aacggcgtgt cgctgtacaa acacacgccc tcgctggtcc
809821 ggttgcccca aaaagccaag ccccccaaac cagttgctcg ccagcaatga cgccggttgc
809881 taccatctga ctccgtgtcg cttcccgggg caggactggg gcagtgggtt atccggtgat
809941 gaccgatggc cggtagcgac ccaccaacag gtgggccggc gtcgcaggcg ggttcagacg
810001 cgggagcctc gccagaacac aaacacatgt cgcggcgaaa gcacctcgtg ctcgatgtct
810061 gcatcatcct gggtgttctc attgcctacg tcttttcgct gctcggctac gactggttgg
810121 cccacacacc gggtccgctt ccgcagccgg acgtgggcac gactgacgac accgtggttt
810181 tgatccgctt cgaggagctg cacactgtgg caaatcgcct cgatgtgaaa gtgctggtgc
810241 tgcccgacga ttcgatgatc gaccatcgcc tccaagtgtt gactaccgac acctcggtgc
810301 ggttgtatcc ggagaacgaa ctcggagatc tgcagtaccc ggtaggaaag ctgcccgcgc
810361 aagtagcgac cacgatcgag gcgcacggca acccgggcgc ctggccattc gatacataca
810421 ccaccgatac ggtccaggcc gatgtgctcg tcggcgctgg cgacaaccgt caatacgtac
810481 ccgcccgggt cgaagtgacc ggatcgctgg aaggctggga catcagcgcc gtccgcgtcg
810541 gggaaagcag ccaaacctct gatcgcccgg acaatgtcat catcaccctg aagagggcca
810601 agggtccgct ggttttcgac ctgggcatct gcctggtgct gatcacattg ccgacgttgg
810661 ccttgttcgt ggccatccag atgattaccg gccgcagaaa attccaacca ccgttcggca
810721 cttggtacgc cgcgatgttg ttcgctgtcg tgccgctgcg cactattctc ccgggctcgc
810781 cgccggcggg tgcgtggatt gaccgggccg ttgtgatctg ggtgctcata gcgctggcgg
810841 cggcgatggt ggtgtacatc gtcgcctggt accgagaatc ggactaaggc gggcgtcaga
810901 tggcttctgt cgacgcgtcc ggagggtttc cgctggattt cataaacagg cgctagcgcg
810961 gtgtccaacg atacgattgg ggcccatgcg gcccgacgag atcggctcgc tgcgggccgg
811021 cctggcggct gttgcgcggt gaactcaaaa cgcgttgacg ccggatcagc tatccgatga
811081 ttcaggcgga gatctcgacg atcgtgggcg ctaccgccaa tccggtatcc gggtagatca
811141 tgatcgacat gggttgatct gccctggtgg ggcggactca cattagcgaa attttgcgct
811201 gagtaggtcg tcccctaaac ttcaggggtt gccgtgagca gacctcggcc ggcgcgcata
811261 agctttgctt ggtcggcccc gcgtgcccgt cggcgacaaa gaccgcgcac gtcagggatg
811321 gtcctggctg gctcctccta ccgtgcacac gtcaaccagg tcaggagatc tagtgattca
811381 gcaggaatcg cggctgaagg tcgccgacaa caccggcgcc aaggagatct tgtgcatccg
811441 ggtgctgggc ggttcgtcgc gacgctacgc cggcatcggt gacgtcatcg tcgccaccgt
811501 gaaggacgcc attccgggcg gcaacgttaa gcggggggat gtcgtcaagg ccgtcgtggt
811561 gcgcacagtc aaggaacgcc gacgtcccga cggcagctac atcaagttcg acgagaacgc
811621 cgcggtgatc atcaagcccg acaacgaccc gcgcggcacc cgcatttttg gaccggtcgg
811681 tcgcgagctg cgggagaagc ggtttatgaa gatcatttcg ctggccccgg aggtgttgta
811741 gatgaaggtc cacaaaggcg acaccgtgct ggtgatttcg ggcaaagata aaggggccaa
811801 gggcaaagtc ttgcaggcgt atccggaccg caaccgggta ttggtcgagg gtgtcaaccg
811861 gatcaagaag cacaccgcga tctcgaccac ccagcggggc gcgcgttcgg gtgggatcgt
811921 cacccaggaa gcgccgatcc atgtctccaa cgtgatggtg gttgactccg acggcaagcc
811981 cacccgaatc ggctatcggg tcgacgagga gaccggcaag cgcgtccgta tctccaagcg
812041 caacggcaag gacatttgat gaccactgca cagaaggttc agccgcgcct caaggagcgc
812101 taccgcagtg agattcggga tgcgctgcgc aagcagttcg gctacggcaa tgtcatgcag
812161 atcccgacgg tgacgaaagt cgtcgtcaac atgggtgtcg gcgaggccgc ccgggacgcc
812221 aagttgatca acggggcggt caacgatttg gcgctgatca ccgggcagaa gccggaagtc
812281 cgccgggcgc gcaagtccat cgcgcagttc aaattgcgtg agggcatgcc ggtgggcgtc
812341 cgagtcacgc tgcgcggtga ccggatgtgg gagttccttg accggctcac gtcgatcgca
812401 ctgccacgca tccgtgactt ccgtgggctt tcgcccaaac agttcgacgg tgtgggcaac
812461 tacaccttcg ggctggccga gcaggcggta ttccacgagg tcgacgtgga caagattgac
812521 cgggtccgtg gcatggacat caacgtcgtc acttccgcgg cgaccgacga cgaaggccga
812581 gcgctgttgc gggccctcgg ctttcccttc aaggagaact gagcagatgg cgaagaaggc
812641 actggtcaac aaggccgcag gcaaaccgag gtttgccgtg cgcgcctaca cccgttgcag
812701 caagtgcggc cgcccgcgtg cggtctaccg caagttcggg ctgtgcagga tttgcctgcg
812761 cgagatggcg cacgcgggtg agttgcccgg cgtgcagaag agcagctggt aacgggacac
812821 ggggactaga acatatgacc gcgctgacga cgatgcagtg ggggtacccc cagacgcgca
812881 gcggcgaggg ggccgcaagc gatgaggagg agtagcgctc gatgaccgcg ctgacgacga
812941 tgcagagcgc aagcgatgag gaggagtagc gctcgatgac gatgacggac ccgatcgcag
813001 actttttgac ccgtctgcgt aacgccaact cggcgtatca cgacgaggtc agcttgccgc
813061 actccaagct caaggccaac atcgcgcaga ttctcaagaa cgaggggtac atcagcgact
813121 tccgaaccga ggacgctcgg gtcggtaaat cgctggttat ccagctcaag tacggcccta
813181 gccgggagcg cagcatcgcc gggttgcggc gggtgtccaa gcccggcctg cgggtgtacg
813241 cgaaatccac caatctgccg cgggtgctcg gcggcctggg cgtggcgatc atctcgacct
813301 cctcgggcct gctgactgac cggcaggcag ctagacaggg cgtgggcggc gaagtcctcg
813361 catatgtctg gtgagagtgt ggtgagagga agcaaccatg tcgcgtattg gtaagcagcc
813421 gattccggtg cccgccgggg tcgacgtcac gatcgaggga cagagcatct cggttaaggg
813481 gcccaagggc accctaggac tgacggtcgc cgagccaatc aaagtggcac gcaatgacga
813541 cggcgctatc gtggtcaccc gtcccgacga tgagcggcgt aatcgctcct tacacgggct
813601 gtcccgtacc ctggtgtcca acctggtcac tggcgtgacg caggggtaca ccaccaagat
813661 ggagatcttc ggggttggct atcgggtgca gctcaagggc tccaatctgg agtttgcgct
813721 ggggtacagc cacccggtgg tgatcgaggc tcccgaagga atcacgttcg ccgtccaggc
813781 accgacgaag ttcaccgttt ccgggatcga caaacaaaaa gtcggccaga tcgccgccaa
813841 tatccgccgt cttcgccgtc ccgatccgta caagggcaag ggcgtgcgct acgagggcga
813901 gcagatccgc cgcaaggtcg gaaagacagg taagtagcca tggcgcaatc agtttccgcg
813961 actcgacgaa tctcccgcct gcgccggcac acgcggctgc ggaagaagct ctcgggcacc
814021 gcggagcgcc cgcggctggt ggtgcatcgg tccgcgcggc acatccacgt gcaactggtg
814081 aacgacctca acggcaccac cgtggccgcc gcttcgtcga tcgaggccga tgtgcgcggc
814141 gtgccgggtg acaaaaaggc ccgcagtgtg cgggtcggcc agttgatcgc cgagcgggcc
814201 aaagccgccg gcatcgacac cgtggtattc gaccgcggcg ggtataccta cggcggacga
814261 atcgccgcgc tggccgacgc cgcacgcgag aacggattga gtttctgatg aacgggagga
814321 ccgcataatg gcggagcagc cggccggaca ggcaggcact accgacaacc gtgacgcacg
814381 gggtgatcgg gagggccggc gccgcgacag cggccgcggc agtcgtgaac gggatggcga
814441 gaagagcaac tatctagagc gggtcgtcgc catcaaccgc gtctccaagg tggtcaaggg
814501 tggtcggcgc ttcagcttca ccgctttggt catcgtgggc gacggtaacg ggatggtcgg
814561 tgtcggctac ggcaaggcca aggaagtacc ggccgcgatc gccaagggcg tcgaagaggc
814621 gcgcaaaagc ttcttccggg taccgctgat cggcggcacc atcacgcacc cggtgcaggg
814681 cgaggcggcc gccggtgtgg tgttgctacg gccggccagc ccgggtaccg gtgtgatcgc
814741 cggtggtgcg gcccgcgcgg tgctggaatg tgcgggggtg cacgacatct tggccaagtc
814801 gctgggcagt gacaacgcga tcaatgtggt gcacgccacc gtggccgcgc tcaagctgct
814861 gcagcgtccg gaggaggtgg cggcgcgccg cggtttgccg atagaggacg tcgccccggc
814921 cgggatgctg aaggcgcgtc ggaaaagtga agcgctggcc gccagcgttt tgccggatag
814981 aacgatatag ccatgtcaca gctgaagatc acccaggtgc gcagcaccat cggagcacgc
815041 tggaagcagc gcgagagcct gcgcactctg ggcttacgaa ggattcgtca ttcggtgatc
815101 cgcgaagaca acgcagcgac tcgcggactg atcgcggtgg tgcgtcacct cgtggaggtt
815161 gagcccgcgc agaccggagg gaagacatag tgacgctcaa gctgcatgac ctgcgccccg
815221 cgcgggggtc caagatcgcc cgcacccgag tcggtcgagg tgacggctcc aagggcaaga
815281 cggccggccg tggcaccaag ggcaccaggg cccgcaagca ggtgccggtg accttcgagg
815341 gcgggcagat gccgatccac atgcggctgc ccaagctcaa gggcttccgt aaccggtttc
815401 gcaccgaata cgaaattgtc aacgtcggcg acatcaaccg gctgtttccg cagggtggtg
815461 ccgtcggcgt ggacgacctg gtggccaagg gggccgtccg caagaacgct ctggtcaagg
815521 tgttgggtga cggcaagctg accgccaagg tcgacgtgtc cgcgcacaag ttcagcggca
815581 gcgcgcgcgc gaagatcacc gcagcgggcg gttcagccac cgagctctag tttcgggcga
815641 gcagacgcaa aatgcccccg aaatgcccat tttcgggggc ttttgcgtct gctcgcgggc
815701 ccttggcggc cggtgggtac gctgggtgaa tatggttgcc tttctgcctt ccattcccgt
815761 tgtcgaggac ctacgcgccc tggtcggccg ggttgatacc gcccgccacc acggtgtacc
815821 caacggctgc gtgctcgaat tcaacctgcg atcggtgccg ccggagacga cgggcttcga
815881 ccctcttacg gtgctcaccg ggggtgggcg gccgatggcg ctgcgcgatg cggtcgccgc
815941 gatccaccgt gccgccgagg acccccgggt agccgggctg atagcccgcg tgcagcttcc
816001 gccctcgccg gcgggggcgg ttcaggagct gcgggaggcc atcgcggcct tcagtgcggt
816061 caagccgtcg ctggcctggg ccgaaactta tccgggcacc ctgtcctact atctggcttc
816121 ggcgttcggt gaggtctgga tgcaaccctc ggggagtgtg gggctggtcg gcttcgccac
816181 caacgccaca ttcctgcgcg acgccctgca caaggcgggc atcgaggccc agttcgtcgc
816241 ccggggcgaa tacaagtcgg cggcaaacct tttcaccgag gatggcttca cagacgccca
816301 ccgcgaagcg gtcacgcgga tgctggacag tctgcaggac caggtgtggc aggcggtcgc
816361 caagtcgcgc aatatcggcg tcgatgcgct tgatgagctg gctgaccggg ctccgctatt
816421 gcgggacgac gccgtgactt gcggtctgat cgaccggatc ggatttcgcg accaagccta
816481 cgcccgtatg gcggaattgg ttggtgtgga aaaaggttca ccggaatcca gtggctcgca
816541 aacaagccca gacgaaaagc cgccgcggat gtacctggcg cgctacgcca gttcggcccg
816601 gccacggctg acgccccccg tcccatcgat tcctggtcgc cggtccaagc cgacgatcgc
816661 ggtggtgacc ctggaaggcc cgatcgtcaa cggtcgtggt gggccccagt ttctgccgct
816721 cggtccgtcg agcgccggcg gtgacaccat cgcggcagcg ctgcgggagg tggccgccga
816781 cgattcggtg tcggcgatag tgctgcgggt cgacagtccg gggggctcgg tcaccgcatc
816841 ggagactatc tggcgtgagg tggccagggc ccgcgaccgt ggcaaaccgg tggtggcgtc
816901 gatgggtgcg gtcgccgcct ccggtggcta ttacgtgtcg atgggtgccg acgccatcgt
816961 ggccaacccg ggcaccatca ccgggtcgat cggtgtgatc accggaaagc tggtggttcg
817021 ggatctcaag gaccggttgg gtgtcgggtc ggatgcggtg cgcaccaacg ctaatgccga
817081 tgcctggtcg atcgacgcac ccttcacccc ggaccagcag gcccatcgcg aggcggaggc
817141 ggacttgttc tacagcgact tcgtggaacg cgtcgccgag ggccgcaaga tgactaccga
817201 cgccgtggac gtcgttgcgc gaggccgggt ctggaccggt gccgacgctc tcgatcgcgg
817261 cctggtcgac gaactcggcg gccttcgaac cgcggtgcgt cgcgcgaagg tgctagccgg
817321 actagatgag gacaccgagg ttcgcatagt cagttatccg gggtcgtcac tctgggacat
817381 ggtgcgaccg cgtccgtcgt cacgaccggc agcggcatcg ctgccggatg ctatgggtgc
817441 gctgcttgcc cgttcgatcg tcggcatcgt cgagcaggtg gaacagactc tcagtggtgc
817501 cagcgtgttg tggctggggg agtcgcgcct ctagccgttc aaacgaccgc tgatgaagat
817561 gatttcgccg agcggatcgt cgtcgtgtgg ggcgggaacg ggcaaaccat tgcgcctgaa
817621 taggtcggtc cgcactgtgc cctcaacgtc ccagcccttg gcgcgcaggt agtcgacgac
817681 gtggctgcgt tcgccggaat acaccagcga cgccatgtcg atgtccacgc cgtgcttgcg
817741 aaacgaatcc gccatttctc gtacccggcc tgcgtcgaaa tccacaatgc ccgggacaag
817801 ttcggtagcg atcgtgctgc ccgcaacact gagttcggtg ctgttgtcga acaaccggtc
817861 ctgggatccg gcggcaggta gatcagcatg ccttcggcca accatgctgt cggtgccgtc
817921 gagtccaggc cggcagcttg cagtgccgcc ggccagtccg cgcgcaagtc gatgtacacc
817981 gtgcgccgaa tggcggtggg cttggcgccg atgccggcca aggtggttgt cttgaagtcg
818041 atcacctgtg gttggtcgat ctcgtagacc acggtgccgg ccggccacgg caaccgatag
818101 gcgcgcgcgt ccaacccggc tgccaggatc accacttgtc gcactccgcc gtccgtggca
818161 gtgcggaagt agtcgtcgaa gtacttggtg cgcaccgcta tcccgtcgat catcgcctgt
818221 gcccgccccg gcgaaaggtt cccggtcgtc gcgatatcga gctcgccgtc gatcaacttg
818281 gtgaagaaat ccagcccgac cgcgcgcacc agcggttcgg cgaacgggtc gttgatcaaa
818341 cctcgtggat ccttggtcgc caacgcgcgt ccggcagcaa ccatggtcgc ggtagccccg
818401 acgctggagg ctagatccca gttgtcgtcg tgagcgcgcg gcatctgcgc cctatgtccg
818461 ggtcgcagcg acgtagttca ttgtgccggg acggccgctg cagcgctgag gtcggccagt
818521 gtacgcgacc gccaactcag ccggtaagcc ctggcggcgg tggagcagtc gtcgaagcct
818581 ggtgagcatc actgcgagtc atcgtgtagg cggccgattt cgacagttca ttgacggggc
818641 aagcggtatg gcgccacgaa ggtgctggct tgcggtgtgc tgggtactgt ctgtgtttcc
818701 gttgcaacct ggcgctgaca tagaagaaat caggcaacgg cacttcttcg tcctcgaacg
818761 gttgaaatcc gttggcggtc agcaggtcct gggatttgat ctcggtcagc agccaaccat
818821 tgtcggatag gtacgaggcg ggctcgttgc ggtcgccgaa gtacaccagc tcattcatgt
818881 ctagatcgaa accgtatgcg cgccaacgat tggcgaggat cgtcatgcgc tccctcatcc
818941 gttcctcatg atgcggcttg aagttgcgta tgctctcggt tgcaaacctg ctgtccggca
819001 cactgagcgc ggtgacattg tccaacaagc ggtcctgcgc ttccggcggg aggtagcgga
819061 gcaacccttc agcgctccac gcggtgggct gggtcgggtc gaatcccgcc gcgcccaacg
819121 cggtgggcca atccgcacgc aaatcggcgg tgaccacgcg ccggtcggcg gtgggcgtgg
819181 cgcccagttc ggcgagtgtg cgagttttga actccatgac ttgcggttgg tcgatctcat
819241 acaccacggt ctgggcgggc caggccagcc ggtatgcccg ggaatccaat cctgaggcca
819301 ggatcacgac ctgcctgatg cccgcgcgtg tcgcatccat gaagaactcg tcgaagaact
819361 tggtgcggac ggcatggtgt tcggccatac ggaccatgga cgcattcggg cgttccggat
819421 cgtcgatgtc tgaggccgtc aattccccgc tcgcgagccg ggtcagaacg tccaccccca
819481 ccgcccggac cagcggctca gcgaactgat cgttgatcag tgggttggcg gcgcgggtcg
819541 ccatcgcgcg agccgccgca accatcgtgg cggtcgcccc gacgctggat gccagatccc
819601 aggtgtcccc ttcgcacctg atggaaccgg tgtatgtcat gcacggcctc tcttcaaaaa
819661 gcggggataa ttccttagta aagttaacaa caggcgacaa attccgcgac ttggaaaggc
819721 tggcgcgatc ggcggcgtcg gggtgccgcc atagggggcg cacgtggggg tcctggctgt
819781 tgagcgtgaa taccgcgatg ggttttcggc gtgtcgcgtg gtgcgattca ctctcggtgc
819841 ggctagagcg gattcgcgcg cagatagccg tagacgcccg tgaagttacg gcacacgtcc
819901 tcaggaattg gcaccggtcc accgagagcg cgggcacccc aaacgatttg tgcggtgcgc
819961 tcaacaaggg cggtgacgcg cagcacctgg tcggggcggg gccccacggc caccaggccg
820021 tggttggcga tcagggcggc ggcgcggccc tcaagcgcgc gcaccgcgtt gcggccgacc
820081 tcgggtgtac cggacgcggc gtactcggtg cagcgaacgt ccccgccgca gtagatcgcg
820141 aactcgtcga tgcaggcggg aatcggctca tgggcgacgg cgaacatggt cgcccacacc
820201 gggtggctgt ggatcacgct gccaatgtcg tcgaatgcgc gatagcacgc caggtgtagg
820261 tttagttcgg tcgacggcga ccggccgtcc ttggcgtgca gcaccgcacc gccggcgtcg
820321 actagcacca gatcgtggag cagcatctcg gcgtagtcga ccgaggacgg cgtgatgacc
820381 acgttgccgt ccgagcgcct ggctgagata tttccggcgg tcccctcgac caggccccga
820441 cgcaacatgt ccttggcggc cgccagcacc gcggattccg gggcgtcaac gaagttcatg
820501 agcccaatac ctccgggttg acgacatggg cgggcctgtt gccggacagc agtgcgccca
820561 ggtcgtcggc gaccatccgc gcctgccggg cctcggtgtt ccaggtggcc ccgccgatgt
820621 ggggggtgag gacgacattg ggcatgctca ccaaagggtg atcggtcggc agccattcac
820681 cggtgaagtg gtccaggccg gcggcggcca gcttgccgcc acgcagggcg tcgacgagcg
820741 catcggtgtc gcgcagctgg gaccgggcgg tgttgagaaa caccgcaccg tcgcgcatgg
820801 ccgcgaactg ctgggcaccg atcatcccga tcgtgtcgtc ggtgaccgcc gcgtgcatgg
820861 agacgatgtc agcctcggcc agcagctcgt caaggctgtg gccggcgtcg tcgcggtaag
820921 gatcgtgcgc gatgacccgc aggcccagcc cggacagcct ccagcgcacc gcgcgaccga
820981 cggcacccag gcccaccagc ccggcagtca gcccggcgat ttcggcaccg cggaaccgct
821041 gataggggat ggtgccgtcg cgaaagatgt tgccggaccg cacatctgcg tccgcgggaa
821101 tcaggtgccg ggcgacggcc agcaacaggg ccaccgtcat ctcggcgaca gcgtcggcgt
821161 tgcgagccgg ggtgtgcagc accggtatgc cggccgcggt ggcgccgggg atgtcgacgt
821221 tgctgggatc cccgcgggtg gcggcgacca cccgcaaccc ccgctcgaac accgggccac
821281 cgaccgagtc actttccacc acaagaacat cggcggcgac ggcggtgatc cggtcagcta
821341 gctgctcggc gctgtagatt cgcagcggtc gctgatcgat ccacgggtcg tataccacgt
821401 cggctagccg ccggagctgg gcgaaccccg gtccacgcaa tggagccgtc accagagcac
821461 gcggtcgagg cgtcacgttt gccaatgctg gcgtacggtg gcgcccgtgt cacgcgacga
821521 cgtcacaatc ggcatcgata tcggcaccac cgccgtcaaa gcggtggccg ccgacgacaa
821581 cggtcgggtg acggcgcggg tacggattgg ccaccagctg gcggtgccgg cccccgaccg
821641 gctggagcac gacgccgacg aagcgtggcg gcggggacca ttggcagcac tggaccggct
821701 ggtcggaccc gacacccggg cactggccgt tgccgcgatg gtgccatcgc tgaccgctgt
821761 cgatcccgct ggccggccga tcacacccgg gctgctgtac ggcgacgcca ggggtcgggt
821821 accgaacgcc tcggtggcac gggcgcagtc ggtgccgtcg gtgggtgaga ccgccgagtt
821881 tctgcgctgg acggccggcc aagcgctgga tgcgtccggg tactggccgg cgccggcggt
821941 ggccaattac gccttgtcgg gcgaagcggt catcgactat gccacggccg tcacgactct
822001 cccgttgttc gacgggacgg gatggaacgc gaccgcttgc gccgactgcg gtgtgaccgt
822061 tgaccggatg ccgcgggtgg agacgttcgg agtgggagtg gggcaggtgc gcggcaccgg
822121 cgcggtgctg gcggtcggtg ccgtcgatgc cctgtgcgaa cagatcgtgg ccggcgccga
822181 ccgcgacggc gacgtgttgg tgctatgcgg cgccaccttg atcgtgtgga ccaccatctc
822241 cgcggctcgt caagtgccgg gtttgtggac catcccgcat acggcaccgg gcaagagcca
822301 gatcggaggg gccagcaacg ctggtgggtt gttcctcaac tgggtggatc gtgttattgg
822361 accgggcgat ccagcgctag ccgatccgcg gcgggtgccg gtgtggctgc cctatatacg
822421 cggcgagcgc accccgttcc atgagcccga tcgccgggcc gtgctcgacg gtgtggatct
822481 ctcccaggac gccgcatcgg tgcggcgggc cgcctacgag gcgtcgggct tcgtcgtgcg
822541 ccagctcatc gagctaagcg gggcgccggt ggcgcgcatc gtggcggcag gcggcggcac
822601 ccggatacag ccttggatgc aggctatcgc cgacgcgacc ggccggccgg tggaggtgtc
822661 cagggtggcc gaaggggcgg cactgggagc ggctttcctc ggccgcttgg cggccggatt
822721 ggaatcgtcg atcgccgacg ctgcccggtg ggcctcaacc gaccgcattg tcgaacccag
822781 tgccgactgg gcggggccga ccaaggaacg ctatcgccgg ttcctggcgc tcagcggctc
822841 gaagttggcc tgacggtgga ccaagatgca tggcgcaaga actggtgtgt cgttctacgc
822901 ttatgcaatg acagatcacg accagaccgc ggcccgtcga gagatcgccg atgccctgct
822961 cgccgcgctg gaacgtcggc atgaggtcgc agacgccatc gtggaggccg ccaacaaggc
823021 cgccgccgtc gaggcgatcg tgaacttgct gggcacctcg cacttggccg ccgaagcggt
823081 gatgagcatg tctttcgatc agctcaccca ggatgcgcgc acaaagatca tcgccgagct
823141 cgacgacctg aacaaacagc tgagcttcac cgtcaaggag cgtccagcca gctctggtga
823201 gggcctggag ctgcggccgt tctccccaga tgaggaccgc gacatcttcg ctcgacgaac
823261 cgaagaaatg ggcgccgccg gcgatggatc cgggggaccc gccggcagcg tcgacgacga
823321 gatccgagcc gcacagaagc gcgtcgacga cgaggaggcg gcttggttcg tggctgttga
823381 ttccggcgtc aaggtcggga tggtgttcgg cgagcttgtc cacggcgagg tggacgtccg
823441 gatctggatt caccccgatc atcgaaaaaa gggttacgga accgcggcat tgcgcaagtc
823501 gcgctcggag atggcctggg cgttcccggc cgtgccgatg gtcgcccgcg cgcccgcggc
823561 ccaacccgcc cagccgggaa gtgccggccg gtagcatccg gttcggtctg gcaggcggtc
823621 gccaggccga tcggcggcga atccgcggcg ccaacgctgc cgccggatcc caactggctt
823681 aatcagcgtg tgtcttggtg tttctgcttc agttcggcgg agacatagat cacctcgccg
823741 aacggggcgt cgtcgccgtc gatcggcggc agtccgtgtt cagccagcaa gtcggtggtg
823801 ctcgcgctgg cggttcgcca gccgtggtcg gccagatagg tccgcgcgtc cgtgcggtcg
823861 ccgaaataca ccaggcccga catgtcgagg tcgaggccat ggcgcctgaa ccgctccgcc
823921 aggcgccgca tgcgtccccg cagttcttct tcgttgagcc gattgatgtc gcgcaggact
823981 tcggtggcga actggctgcc cggtacgctc tgggcggtga tctggtcaag cagccggtcc
824041 tgcgcctcgg cggacagata gcccagcagc ccctcggcga tccaggcggt ccgctgcgcg
824101 ttgtcaaagc cggctttttg cagggcggtg ggccagtcgt cgcgcaaatc gaccgccacg
824161 gtgcgccggt cggtcgtggg tgccgcaccc aggccggcca gcgtcgtggt cttgaagtcg
824221 atcacctgcg gctgatcgac ttcgaagacg atggtgccgg ctggccagcg cagccggtag
824281 gcgcgggaat ccaggccgga agccaagatg acggcctgcc gaatcccggc tcgggtggca
824341 tccagaaaga agttgtcgaa gtagtgagtg cgaatggcca tcgcgtcggc gaaccgccgc
824401 aggccgttgg cctcgtcttc ggctagctcg tcgggatcca gttcgccact ggccatgcgt
824461 acgaagaagt cgacgccgac cgcgcggacc agcggttccg cgaactggtc gttgaccagc
824521 gcgccgggag cccggccggc taccgctcgg gccgccgcca ccatggtggc cgtcaaaccc
824581 acactggacg ccaagtccca cgaatcgccc tcaaagcggg cactgcccgt ttgcgtcatc
824641 tgtaacccct tcgatagctc gcaccgtggc ggcccggaac gggccagtcc ataccagctg
824701 ttagtctctt acacgatttg gcgcgcgacg ccgtacgtcc tggcctgcgg gtgttgggcg
824761 cgtgatgcaa gatgaccccg ggctgcgcag gaggatagag tgctttcggc tttcatctcg
824821 tcgctgcgaa cagtcgactt gagacgaaag atcctcttca cgctgggcat cgtcattctc
824881 taccgtgtcg gtgccgcgct gccgtccccc ggtgtcaatt ttccgaacgt gcagcagtgc
824941 atcaaagaag ccagcgcggg cgaagccgga cagatctatt ccctgatcaa cctgttctcc
825001 ggcggtgcgt tattaaagct cacggtgttc gcggtggggg tgatgcccta catcaccgcc
825061 agcatcatcg tgcagctgct caccgtggtc atcccgaggt tcgaggaact ccggaaggaa
825121 ggccaggcgg gtcagtcgaa gatgacccag tacacccgtt acctagcgat cgcgttggct
825181 atccttcaag ccaccagcat cgtggcgttg gctgccaacg gcgggttgct acaaggttgc
825241 tcgctggaca tcatcgccga ccagagcatt ttcacactgg tcgtcatcgt gctcgtgatg
825301 acgggcggcg ccgcgttggt gatgtggatg ggcgagttga tcaccgaacg cggcatcggc
825361 aacggcatgt cgctgctgat cttcgttggc atcgctgccc gcatcccggc cgaaggtcaa
825421 agcatcctgg aaagccgcgg tggagtcgtc ttcaccgcgg tctgcgcggc cgcgttgatc
825481 atcatcgtcg gtgtggtgtt cgtcgaacag ggtcagcgcc ggattccagt gcaatacgcc
825541 aagcgcatgg tgggccggcg gatgtatggc gggacttcga cttatctgcc gctcaaggtc
825601 aaccaggccg gcgttatccc ggttatcttc gcgtcgtcgc tgatctacat tccgcacctg
825661 atcacccagc tgattcgcag cggcagcggt gtcgtgggaa acagctggtg ggacaaattc
825721 gtcggcacgt acctgtccga cccgagcaac ctggtctaca tcggcatcta cttcggcctc
825781 atcatcttct tcacctactt ctacgtgtcg atcaccttca accccgacga acgtgccgac
825841 gagatgaaga agttcggcgg cttcattccg ggaattcggc cgggccgtcc gaccgcagac
825901 tatctgcgct atgtgctgag ccggattacc ttgccgggct cgatttacct cggcgtgatc
825961 gccgtgctgc ccaacctgtt cctccagatc ggcgccggtg gaaccgtgca gaacctgccc
826021 tttgggggta ccgcggtgct gatcatgatc ggtgtcggtt tggatacggt caagcagatc
826081 gagagtcagc tcatgcagcg caactacgaa gggttcctca agtgagagtt ttgttgctgg
826141 gaccgcccgg ggcgggcaag gggacgcagg cggtgaagct ggccgagaag ctcgggatcc
826201 cgcagatctc caccggcgaa ctcttccggc gcaacatcga agagggcacc aagctcggcg
826261 tggaagccaa acgctacttg gatgccggtg acttggtgcc gtccgacttg accaatgaac
826321 tcgtcgacga ccggctgaac aatccggacg cggccaacgg attcatcttg gatggctatc
826381 cacgctcggt cgagcaggcc aaggcgcttc acgagatgct cgaacgccgg gggaccgaca
826441 tcgacgcggt gctggagttt cgtgtgtccg aggaggtgtt gttggagcga ctcaaggggc
826501 gtggccgcgc cgacgacacc gacgacgtca tcctcaaccg gatgaaggtc taccgcgacg
826561 agaccgcgcc gctgctggag tactaccgcg accaattgaa gaccgtcgac gccgtcggca
826621 ccatggacga ggtgttcgcc cgtgcgttgc gggctctggg aaagtagtca tgcgcccact
826681 ggcacggctg cggggtcgca gggtcgtgcc gcagcgcagt gccggcgaac tcgacgcgat
826741 ggccgcggcg ggcgccgtcg ttgccgccgc gctgcgggcg atccgtgcgg cagcggctcc
826801 cggcacatcc agcctgagtc tcgacgagat cgccgagtcg gtgatccgcg aatccggcgc
826861 caccccgtcg tttctgggct atcacggcta cccggcctcg atctgcgcgt cgatcaacga
826921 ccgggtggtt catggcatcc cgtcgaccgc cgaggtgctc gcgcccggtg atctggtatc
826981 catcgactgc ggtgcggtgc tggacggttg gcatggcgat gcggcgatca ctttcggggt
827041 tggcgccctg agcgacgccg acgaagcgct gtcggaggcg acaagggaat cgcttcaggc
827101 cggcatcgcc gcgatggtgg tcggcaatcg gttgaccgac gtcgcgcatg ccatcgaaac
827161 gggtacccgt gccgccgagc tccgttatgg acgctcgttc gggatcgtcg ccggttacgg
827221 gggccacggc atcggccgcc agatgcatat ggatccgttc ttgccgaacg agggtgcgcc
827281 ggggcgcggt ccgctgctgg ctgccggctc ggtgctggcc atcgaaccga tgctgaccct
827341 cggtaccacc aaaacggtgg tgctcgacga caaatggacg gtcacgaccg ccgatgggtc
827401 acgtgcggca cactgggaac acaccgtggc ggtaaccgac gacgggcccc gaattctgac
827461 gctcggttag cgcggctgcc ggcgcgggca gtggtgaacc aaactcttac tcgactcgtg
827521 tcagtaagcg ggaggtgatc gcgtggctcg tgtgtcgggc gccgcggccg ctgaagccgc
827581 gttgatgagg gcgctctacg acgagcatgc cgccgtgttg tggcgttacg cgctgcgctt
827641 gaccggggat gcggcccaag ccgaagacgt cgtccaagag acgctgttgc gggcgtggca
827701 gcatccggag gtgatcggcg acaccgcgcg gccggcaagg gcgtggttgt tcaccgtcgc
827761 gcgcaacatg atcatcgacg agcggcgcag cgcccggttc cgcaatgtgg tcggttcgac
827821 cgaccaatcg ggcacacccg agcagtcgac gccggacgag gtgaacgccg cactggatcg
827881 gctgctgatc gccgatgcgc tggcccaact gtccgccgag catagggccg tgatccagcg
827941 gtcctactac cgcggatggt cgaccgcaca gattgccacc gacctcggaa ttgccgaagg
828001 aacggtgaag tcgcgattgc actacgccgt gcgcgcgttg cggctcactc tgcaggaact
828061 gggagttact cgatgacggc agagcccatt cgcatggctg ccggctccgg atacgtgagg
828121 gtgacaggag agagatgaca tgacgatgcc gctacgagga cttggcccgc ccgatgacac
828181 cggtgtgcgc gaggtgtcga cgggtgatga tcaccactac gcgatgtggg atgcagctta
828241 cgtgttggga gcattgtctg cggccgaccg ccgcgaattc gaagcgcacc tggccggttg
828301 ccccgaatgc cggggggccg tcaccgaact ctgcggggtg cccgccctgc tgtcccagct
828361 cgatcgtgac gaagtggccg cgattagcga atccgccccg actgtggtgg cttcggggct
828421 gtcgccggag ttgttgccgt cgttgctggc ggcggtgcac aggcgtcggc gccgtacccg
828481 gctgatcacc tgggtggcct cgtccgccgc tgccgcggtg ctggcgatcg gtgtgctagt
828541 cggtgtgcag ggccactccg cggcaccgca gcgggcggcc gtgtcggcgc tgccgatggc
828601 ccaggtcggc acgcagctgt tggcgtccac ggtgtcgatc agcggcgagc cttgggggac
828661 gttcatcaac ctgcggtgcg tctgcctggc gccgccgtat gcttcccacg acacgctggc
828721 catggttgtg gtgggtcgtg acggcagcca gacacggctg gcgacttggt tggccgaacc
828781 cggtcacacc gcgacacccg ccggcagcat ttcgacaccg gttgaccaga tcgccgccgt
828841 gcaagtggtt gccgccgata ccggccaggt tctgctgcag cgttcgctct aagactgagc
828901 tttaggcacc tggcgccctg ctattggcac gccctacaag caccaggtgg tcgggcgtcg
828961 accacctgct cggagtgggc tgcatgatgc cgcgcatctt cagtcgtcga tcaccgtggt
829021 gctggccaaa cacgagttct ccgctgccac ggtggccgac gggtacagcc gcagcggggc
829081 cgggttcggg gtcgcggcgg cggcctccgg tggcggcact ttcctcggtc agaaatgcgc
829141 cgcagcaacg gcaagctgaa ttccgtaagg ttggcccgcg tcgacgcatg tgcgataaga
829201 aggggcgtgg cctcagataa tcgcgacccc atcgccgcag cacgggccaa ctgggagcgt
829261 tccgggtggg gtgatgtgtc gctaggcatg gtggcggtga cgtcggtgat gcgtgcgcat
829321 cagattctgc tggcccgcgt cgagacggcg ctgcgcccct atgacctgag tttctcccgc
829381 ttcgagctgc tgcggctgct ggcgttcagc cgtatcggag cgctaccgat caccaaagcg
829441 tcggaccgat tgcaggttca cgtgaccagc gtcacccacg cgatccgccg gctggaggcc
829501 gatggattgg tgcggcgggt tccgcacccc accgacgggc ggaccacact ggtgcagatc
829561 accgagctgg gtcgctccac ggtcgaggac gccaccgtca ccctcaacga gcaggtgttc
829621 gccaacgttg ggatgggcgc cgaggaatcg caggcgctgg tgtcggccgt cgaaacgttg
829681 cggcgcaacg ccggcgactt ttgagggcgg gcagacgcgt aagcgcccaa tgtcgtgccg
829741 aaatgggcgc ttatgcgtct gctcgcgccc ggcttggcgc gcagccggcg acattccatg
829801 accagtttgt gcgggccttg acgcgggcgc gggctcgtat gcgaccgccg aggccggccg
829861 gcttgctgct gggcaatggc ggggctcggc ggtatccggc ggcgggcagc taaccggact
829921 gccccgaaac ccactgcgtg gtcaacgatt tcaggacaag ctgttagcag gacgtgcccg
829981 cgctgcgcta tccaaaaacg tcatgggcac gcatgatggt gaaatgcggc ggacaccaat
830041 tcaaccgcga aaggcaggac agtggaccca ctgatggctc accagcgcgc tcaggacgcg
830101 ttcgccgcgc tcctggccaa cgtccgcgct gaccagctcg gcggccccac gccctgctcg
830161 gagtggacga tcaacgatct gatcgagcac gtcgtcggcg gcaacgagca ggtcgggcga
830221 tgggcggcca gccccatcga gccacccgcc cggcccgatg gcctcgttgc cgcccaccaa
830281 gccgcggccg cggtcgccca cgagatcttc gcggcgccgg gcgggatgtc cgccacattc
830341 aagctgccgt tgggcgaggt tcccgggcag gtgttcatcg ggttacgcac caccgatgtg
830401 ctgacccacg cgtgggatct tgccgccgcc accggccaat ccaccgatct tgatcccgag
830461 ttggccgtcg agcggctcgc cgccgcgcgt gccttggtgg ggccgcagtt ccgcgggccg
830521 ggaaagccct tcgcggacga gaagccttgc ccgcgtgagc gcccgcccgc cgatcagctg
830581 gcggcatttt tgggccgcac ggtgcggtga acccgcgaat tcggctgccg cgcaacgtgt
830641 ggatcaccgc gctgcggtcc agggcgccgt ggtcggcggc gaatctggcg tagatttcgg
830701 cggggtggcc acctagcggc gccgccgcac cggtcgaggc caccgcttcc atggccaggc
830761 ccacatcttg atcggcgtgg tggccacgcc cggtgtgaag tgctgttggc cgtgatgtcg
830821 gattacagtc tcggcgtgcc cgacgagaca ggccttggtg ctgacgcggc gcgcgcgtga
830881 agtggcgctg acacagcaca ttggggtatc cgcggagacc gatcgggccg tcgtccccaa
830941 gctgcgccag gcctatgaca gcctggtgtg cggtcgccgc cggcttggcg ccattggagc
831001 cgagatcgag aacgcggtgg cccatcagcg cgcgctgggc cttgacaccc cggccggtgc
831061 ccgtaacttc tcccggtttc tcgccaccaa agcacacgac atcacgcgag tgctggcagc
831121 aaccgccgcg gaatcccagg ccggcgcggc gcggttgcga tccctggctt cgtcctatca
831181 ggctgtggga tttggcccca aaccccagga gccgcctccg gatccagtgc catttccgcc
831241 ctaccagccg aaggtgtggg cggcgtgccg ggcgcgtggc caagacccgg acaaggtcgt
831301 caggacgttc catcacgcgc cgatgagcgc gagattccgc tcgctaccgg ccggagactc
831361 cgtgttgtac tgcggcaatg acaagtacgg gctgctgcac attcaggcca agcatggacg
831421 ccaatggcac gatattgcgg atgcacgatg gccgagtgca ggcaattggc gctatctcgc
831481 cgattacgca atcggtgcca cactggccta cccggagcga gtggagtaca accaagacaa
831541 cgacacgttc gccgtatacc ggagaatgtc gttgccagac ggcagatacg ttttcacaac
831601 ccgcgtcatt atttcggcac gcgacgggaa gatcattacg gccttcccgc agacgacgtg
831661 atgcgtcggt tgggaactaa gggaaggtga tggcgtgacc gggccaccgc gaagctatac
831721 agggcgccgg gatctcatcg cggagaagct ggagccgtac tttcagatca gcgccatgct
831781 gccgaagaac accagaccca cctcggaaac cgccgaagag ttctgggaca actcgctgtg
831841 gtgcagctgg ggcgaccgag aaacgggata cacccgcacc gtcacggttt cgatctgcca
831901 ggtggcggac ggcgaacgtg aggccgaagg ggttcgggac atgatgcggc tggagtgtcc
831961 ggctgggctg gatctacgga cacccaaccc ggaggcatac gagattaccg gtcagcggcc
832021 cggagaattc gtgttcgtgc tcggctatct ggggcatgtg cgggccatcg tgggcaactg
832081 ttacatcgag atcatgccga tgggcaccag ggtcgagctg agcaagttgg ccgatgtggc
832141 attggatatc ggccgcagtg tcggatgctc ggcctacgag aacgacttca cgctgccgga
832201 cattccaacg cagtggcgca accagccgct gggctggtac acgcaaggcc ttgcccccta
832261 cctgccgggg ctgtcggacc cgaaagacgc cgccgagggc tgatgggtgt gccggcgacc
832321 tctgagggcg agcagacgca taagcgccca atttcgggct cttctgaccc ttccgtgggt
832381 ggaaccttgg tctgagtagg cgcacgtcgt tgtagcttaa ggttgctggt ttgtcaaagg
832441 tccgaaacca aggggagcga gcaacgacgt gcgcaatgcg aggttgtggc gtgaactgct
832501 gggtgttgat aagcggacgg tggcctacgc caggtgtttt cggtcaaagg cgaagaaggc
832561 aagcaggcac tggatcggtg gatctcctgg gcgcggcgct gccgcatccc cgtcttcgtg
832621 gagctggccg gcggcatcgt gcgacaccgc caagccatcg acgccgccct tgaccacggc
832681 ctatggcaag gactgatcga atccaccaac accaagatcc gactcctaac ccggatcgcg
832741 ttcggattcc gctcccccga agcactcatc gccttggcca tgctcgccct cggcggccgc
832801 cgccccgccc taccgggcag aaccaaacac ccacggatca gtcagtagag ccggaaaacc
832861 tgggatttcg ctgcccgttg gacggtgcaa tgcgcttctg tccatgagtc gctggaagac
832921 ctgggcatct cgcccgggtt gtcctggctt attgggccat gacctcttgg gaggtgtcac
832981 atatcgtttg tgatcgcggc gccggaggcc atcgcggcag cggccacgga tttggcaagc
833041 atcggttcga cgatcggggc ggccaacgcc gcggccgcgg ccaacacgac ggcggtgctg
833101 gccgcgggcg ccgatcaggt gtcggtggcc atcgcggcgg cttttggggc gcacggccag
833161 gcctatcagg cgctcagcgc gcaggcggcg acgtttcata tccagtttgt gcaggccttg
833221 accgcgggcg cgggctcgta tgcggccgcc gaggccgcca gcgccgcgtc cataaccagt
833281 ccgctgctcg acgcgatcaa cgcgcccttc ctggcggcgt tggggcgccc gctgatcggt
833341 aacggcgccg acggggcgcc ggggaccggg gccgccggcg gggccggcgg attgttgttc
833401 ggcaacggcg gcgcgggcgg gtccggcgcg cccggcgggg ccggcggatt gttgttcggc
833461 aacggcggcg ccggcggccc cggcgcgtcc ggcggcgcgc tgggctgatc ggcaacggcg
833521 gtaacggcgg taagggcggg cttggggtcc cgccgggtgt cggtggtacc ggcggcgccg
833581 gggggctgct gctcggcctg gatgggttga cgtaggcggc ggcccgcagc ccgccgggct
833641 ccacgtcatc tggcgctgct ggcagaccaa cgctccctac gagcccacgc gccaccgagc
833701 cctccagggc cctgctggcc caacatcaac gaacggatac ctgggacagg acgactggaa
833761 ggcgggcagt tgacccatgc cgaataccgg tggcagcctg ctgcacatcg catccacttc
833821 cgggcgacca acacgtcgag cagccgcgac atccgcggca tgcaatgctg gcggcgcgac
833881 aggtgctagg aggagtggtt gcccgcaccg tagtagttca gccaggccgc aatgcgttga
833941 ccgatacgcg ggtcggtttc ctccggcagc agcaaaaccc gagcctggat cacacccacg
834001 tcgagcaggc cgcttcggat gagggcggcc acgaaagctt tgtccttctc gcgtccggcg
834061 gcaagtttcg ccaccgcgag gtcgtgcggt tccagaaagc gtggtttcgc cgggcgcgag
834121 gattcgacgg tccaactgac cagccggtcc cgccacccgt taggcaggat cgcggtgtcg
834181 atatgtacgc cctcggcata aacgccattg ctgcggtgaa aatcggacat ctcgccgatt
834241 gccacgtcga catgatccgc tttgtcccgc gccgggtcgt tgacaaacgc gatgtcggcc
834301 tcctgggagg cggtggcctg cggcggtagt tcgttttcat caaatgaccc caggatcgac
834361 tgcgacccga gtaccagcac gtccacatcg cccacaacag cacaggcgcg gcggaggaga
834421 tgtgcaagtt gctgacgcgt cattccgtca tggcccgctc gtgctcgcga tcccagtgat
834481 ccttgaacga ccgcagcacc gcgaccctcg tcgcctccgg cagtatgccc gcgaacgggg
834541 agttctgccg catctcccga gcgtcctccg aagggctggt caatacgtgc atgaccgcgt
834601 cgaggccgtc gttaaggaca cgctgccact tcgtgaaata ccaccccgcc atgccgtccc
834661 gacgatgcat acccgaccag cgacgcaagt tctctcgtgc ggcggagacg accgtatccg
834721 gttcggtcaa cagcgggctc agcagggcgc gatgcagcca cagcgacctt tcctcctcgc
834781 gggtcaaccg gcggctcgtg acgcgctcga cttcgctact gggcacccgc cgatggctgc
834841 cgacgtgcac gcacaccatc tcgccgcggt cacacatgtt gacgacatgc tgccgcgata
834901 ccccgagtat ctgcgcggcc tcactcgtct tcagcagagt ctccatgtcc caatgctggc
834961 tagtaaaccc aaaaaacaca acatcgttgc ggagcgtgat cgcaccggct gacgctagag
835021 cgagggcccc agttccgcgg ccgacaggtg gcagtgagct agctgccgcg cagcgtctcg
835081 atcactgcgc tgaagtccaa gtcggcgtga tcggcggcga acttggcgta gatctgggcg
835141 gcgtggctgc ccagtggggc cgccgcaccg gtcgaggcca ccgcttccat cgccaggccc
835201 aacatgccag gtgctgccga ctacggcggt gatccacacg gtcacggcgg aagcattggg
835261 ccgcatcggt attgatgcgc cgcggattcc tggatcgttg gacgtcgccg cgcatgcggc
835321 gatcgggctg ctgccgttgg tggccggctg cgaccgccga catcggcggc ctgtccgcgg
835381 tgctcgggcc ggacgggctg cccaagtgtc tttgtgtatg acggctatcc gggtggagcc
835441 ggtttcgtcg aacgcggttt gcaccggccc cgcggcgcag gtgggtgacc agtcacgctc
835501 accgcagcgc gattacgcgc accaggcctt gcaacccgat gtgccgcggc gccgcgcgcg
835561 gcggcacaga ccccgccggt gttcggcaaa aacggggtcg tcgtcttcga cgatgcggtg
835621 tacttgtcat cagaatcagt gtctatggtc atcgggggtg tcgtgggcgc tggcccgctg
835681 actcgggtgg gaggtggcac atgtcgttcg tgctggcgat gccggaggtg ttggggtcgg
835741 cggcaacgga tctggccgct ctgggctcgg tgctgggcgc ggccgatgcg gccgcggcgg
835801 ctacgacgac gggcatcgtg gccgcggccc aggatgaggt gtcggcggcg atcgcggcgt
835861 tgttttccgc ccacggccgg gcctatcagg tggccagtgc gcaggcggcg gcggttcacg
835921 cccagttcgt ggaggcgttg agcgcgggtg cgggggccta cgccagcgcg gaggccgccg
835981 gcgcggcggt gctggccaac ccggcgcaga gcgtgcagca ggacctgctg gccgccgtca
836041 atgcgcaaag tgtcgcgctc acggggcgcc cgttgatcgg caacggcgcc aacggggccc
836101 cgggcacggg ggccaatggt gcgccgggcg ggtggttgct cggtaatggt ggggccggcg
836161 ggtccgccgc cgctggctcg ggcctgcccg gcggggccgg cggggccgcc gggttgttcg
836221 gcaccggcgg ggctggtggg gccggcggga gttccacggt aggtgatggc gaggccgggg
836281 gtgccggtgg atcaggtggc tggttgttgg gcaccggtgg ggtcggcggg gtcggcgggc
836341 tcggggccgg cgccggtggg gccggcgggg ttggtggggc cggcgggctg ttgggtgctg
836401 gcgggcacgg cggcgccggc gggctaggcg ccgtcaccgg tggggtcggg ggaactggcg
836461 gagccggtgg gctgctggcc gggctgctgg ccgggccggg cggggccggc gggaccggcg
836521 gacgtggctt tctcaacaac ggtggggtcg gtggggctgg cggcaacgcc gggctgctgt
836581 tcggtgccgg cggcaccggt ggatccggcg gagccggcct aggtggtgac ggtggggccg
836641 gtggggccgg cggcaacacc ggtgtgctgt tcggcaacgc cggatccggg gggaccggcg
836701 ggttcggcga taccgacggg ggagccggcg gtgccggcgg tgacgccggc tggttgggct
836761 ccggtggggt cggcggggcc ggcgggttcg gcgaaaccgg tgacgggggt gtcggcgggg
836821 ccggcggcaa ggccgggttg ctgatcggta acggcggggc cggcggcgcc ggtgggcaag
836881 gcgccgtgac cggcggtacc ggcggggccg gcggcgacgg ggtgctgatc ggcaacggcg
836941 gcaacgccgg catcggcgga accggaccga ccgcgggtga taccggcgcg ggtgggatca
837001 gtgggctgct gctgggcgcc gacggcttca acaccccggc cagcgcctct ccgctgcaca
837061 ccctgaaaca acaggcgctg gccgcgatca acgcgccgac ccagacactg accgggcgac
837121 cgctgatcgg caacggcacc cccggggcgg tcggcagcgg ggccaccggg gcccccggtg
837181 ggtggctgct cggcgacggc ggggccggcg ggtccggcgc ggcgggctcg ggcgcgcccg
837241 gcggggcggg cggggctgcc gggctgtggg gtaccggcgg ggccggcggg gccggaggca
837301 gctcggcggg tggcggcggg gccggtgggg ccggcggggc cggcggctgg ctgctcggcg
837361 acggcggggc cggcgggatc ggcggagcca gcaccgtact cggcggcacc ggcgggggag
837421 gcggggtcgg tgggctgtgg ggcgccggtg gggccggcgg ggccggtgga accggccttg
837481 ttggtggcga cggcggggcc ggtggggccg gcgggaccgg cggactgctg gccgggctga
837541 tcggtgccgg cggaggtcac ggcgggaccg gcgggctcag cactaatggc gacggcgggg
837601 ttggcggggc cggcgggaat gccggaatgc tcgccgggcc gggcggcgcc ggcggagccg
837661 gcggtgacgg cgaaaacctg gacaccggtg gggacggcgg ggccggcggt agcgcagggc
837721 tgctgttcgg cagcggcggc gccggcggcg ccggcggatt tggtttcctc ggtggggacg
837781 gcggggccgg tggcaacgcc gggctgctgt tgtccagcgg cggggccggc gggttcggcg
837841 ggttcggcac cgccggtggg gtcggtgggg ccggcggcaa tgccggctgg ctgggcttcg
837901 gcggggccgg tggcgtcggc ggcagcgccg ggctgatcgg caccggcggc aacggcggca
837961 acggcggcac cggcgccaac gccggcagcc ccggaaccgg cggcgccggc gggttgctgc
838021 tgggccaaaa cgggctcaac gggttgccgt agccgggcgg cacggcatgg cttccgggcg
838081 tcaaccactc gccggtgatg cagatcggct gcggagcggg ccgccaaaat gggggccgcc
838141 gcgccaggta tctcggcgaa gatccccggc gctcgagcgc tttgtcagag gcccgtcgcg
838201 ggtcgtcgtg acgacggcta tccgggcggt gcgggtttcg cggcgcgccc tgtgcccggc
838261 accgccgccc gtttgtcggc aacgccgccg cgacccgtga gccgtccagc agctggcgcc
838321 tgcgaaacgt gtggaagcgc tgcatgcggt gccggatcgc gatatcgttg atttctgcaa
838381 ttaattccta cccgtacggg tgtgtcgctg gtagtcgggc accaggccgt gaggggttgg
838441 gaggcatgcg atgtcatggg tgatggtttc gccggagctg gtggtggcgg cggcagcgga
838501 tttggcgggg atcgggtcgg cgattagctc ggctaatgcg gcggcggccg tcaacacgac
838561 gggattgttg accgcgggtg ccgatgaggt gtcgacagcg attgcggcgt tgttcggtgc
838621 ccaaggccag gcctaccagg cggcgagcgc acaggcggcg gcgttttacg cccagttcgt
838681 gcaggccctg agcgccggcg gaggcgcgta tgcggccgcc gaggccgccg ccgtgtcgcc
838741 gctgctggcc ccgatcaacg cgcaattcgt ggcggccacc gggcgcccgc tgatcggcaa
838801 cggcgccaac ggcgcccccg ggaccggagc caacggcggg cccggcgggt ggttgatcgg
838861 caacggcggc gccggcgggt ctggcgcccc cggcgctggg gccggcggta acggcggggc
838921 cggcgggctg ttcggcagcg gcggggccgg cggggcctcc accgacgtcg ccggcggggc
838981 cggtggggcc ggcggggccg gcggaaacgc cggcatgctg ttcggcgccg ccggggtcgg
839041 cggcgtcggc ggattctcga acggcggtgc caccggcggg gcaggcgggg ccggcggggc
839101 gggcgggctg tttggcgccg gaagggaacg cggcagcggc gggtcgggca acctcactgg
839161 cggggccggc ggggccggcg gcaacgccgg gacactcgcc actggtgatg gcggggccgg
839221 cgggaccggc ggcgctagtc gcagcggcgg attcggcggg gccggcggag ccggcggcga
839281 cgccggcatg ttcttcggct ccggcggctc cggcggcgcc ggcggcatta gtaaaagcgt
839341 cggggacagc gccgccggcg gggccggcgg ggcccccggg ctgatcggca acggcggcaa
839401 cggcggcaac ggcggcgcga gcaccggcgg cggggacggt gggcccggcg gggccggcgg
839461 caccggcgtg ttgatcggca acggcggcaa cggcggcagc ggcgggaccg gcgcgaccct
839521 gggcaaggcc ggcatcggcg gtaccggggg ggtgctgttg ggcctggacg gctttacggc
839581 ccccgccagc acctcgcccc tgcacaccct gcagcaggac gtgatcaata tggtgaacga
839641 ccccttccag acgctcaccg ggcgtccgct gatcggcaac ggcgccaacg gcactccggg
839701 gaccggggct gacggcggag ccggcggctg gttgttcggc aacggcggaa acggcgggca
839761 gggaacgatc ggcggcgtca acggcggggc cggcggggcc ggcggggccg gcgggatctt
839821 gttcggcacc ggcggcaccg ggggcagcgg cgggcccggc gccaccggcc tcggcgggat
839881 tggcggggcc ggcggagccg ccttgctctt cggctccggc ggggccggcg gaagcggtgg
839941 tgccggcgcg gtcggtggca atggcggggc cggcggcaac gccggtgcgc tcttgggcgc
840001 cgccggggcc ggcggggccg gtggtgccgg cgcggtcggt ggcaatggcg gggccggcgg
840061 taacggcggg ctgttcgcca acgggggagc cggcgggccc ggtgggtttg gcagccccgc
840121 tggggctggc gggatcggcg gggcaggtgg gaacggcggg ctgttcggcg ccggcgggac
840181 cggcggggcc ggcgggggaa gcaccctcgc cggcggcgcc ggcggggcgg gcggcaacgg
840241 cgggctgttc ggcgccggcg gcaccggcgg cgccggcagc catagcaccg ccgccggagt
840301 ttccggaggg gccggcgggg ccggcggcga cgccggcttg ctctccctcg gcgcctccgg
840361 cggggccggc ggcagcggcg gttccagcct gaccgccgcc ggcgtggtcg gcggcatcgg
840421 cggcgccgga ggcttgctct tcggctccgg cggcgccggc gggagcggcg ggttcagcaa
840481 ctctggcaac ggcggcgccg gcggggccgg cggcgacgcg ggtttgctcg tcggctccgg
840541 cggggccggc ggggccggcg cctccgccac cggcgccgcc accggcgggg acggcggggc
840601 cggcggcaag tccggagcgt tcggtctcgg aggtgacggc ggcgccggcg gcgccaccgg
840661 tttgtccggt gctttccaca tcggcggcaa gggcggcgtc ggcggcagcg ccgtgctgat
840721 cggcaacggc ggcaacggcg gcaacggcgg taacagcggt aacgccggga aatccggggg
840781 tgcacccggc cccagcggcg ccggcggcgc cggcgggctg ctgctcggtg agaacgggct
840841 gaacggcttg atgtagccgg cgggcctgcg accgcgcgcg gcgttgacag catcgcttcg
840901 gccgctcgac cgcagatgat gctgttgatg cgttaccgtg tgcatcatgc gcaccacggt
840961 gtcaatctcc gatgaaatac tcgctgccgc caaacgccgg gcccgcgagc gtggtcaatc
841021 gctgggcgct gtgatcgagg acgcccttcg gcgggagttc gccgccgccc acgtcggcgg
841081 cgcccgcccg accgtcccgg ttttcgacgg cggcaccggt ccgcggcgag gcatcgacct
841141 gacctcgaat agagcgttgt ccgaagtgct cgacgagggc ctggaactga actcccggaa
841201 gtaaccccca ataggcgcag aacggcaatg ttccttctcg acgccaacgt gctgctggct
841261 gcacaccgcg gtgaccaccc gaatcaccga accgtccgcc cctggttcga tcgactgctc
841321 gcggctgacg accccttcac agtgccgaac ctggtatggg cgtcgttcct ccggctggca
841381 acgaatcgac gcatcttcga gattccgtca ccgcgagcag aggcattcgc attcgtcgaa
841441 gccgtcaccg cccagcccca tcaccttccg acgaaccccg gtcccagaca cctcatgctg
841501 ctgcgaaaac tctgcgacga ggccgacgca tcgggcgact tgatacctga cgcggtactc
841561 gcggccatag cagtggggca tcactgcgcc gtggtgagcc tggacaggga tttcgcccgg
841621 tttgcctcgg tgcgccacat tcgcccgccg ctctagcgag cggtcctcaa gtacagtcgg
841681 cgaccggaca aaccgctgcg ccagacgatt caccgtcctc gcgtcaattc gagcagctac
841741 ggccgaaagc caagggcctt cttggtcggg gtgaaaaagt tcagacgcag cgacaccagc
841801 tgccacagct ggttgagcaa ctccagttcc tcggtgctgt cgtagcgcca gtggaacgcg
841861 tgtttgcgca ccacacggtt gttctttcga ctccacgtgc gcctggtcgt tcgtctggta
841921 caccaggcta ccgggctatc ggattcggcc ccaaacctca ggagccgcct ccggatccgg
841981 tgccgtttcc gccctaccag ccgaaggtgt gggactaaac tatctagggc aagtgcgggc
842041 catagtgggc gactgcgtca tccacatcat gccgatgggc accggggtcg agctgagcaa
842101 gttggccgat ctggcattgg atatcggccg cagtgtcgga tgctcggcct acgagaacga
842161 cttcacgctg ccggacattc caacgcagtg gcgcaaccag ccgctgggct ggtacacgca
842221 aggccttgcc ccctacctgc cggggctgtc ggacccgaaa gacgccgccg agggctgatg
842281 ggtgtgccgg cgacctctga gggcgagcag acgcataagc gcccaatttc gtgtcgaaat
842341 gggcgcttat gcgtctgctc gcgcgcgcaa cgtgtggatc accgcgctga agtccaggtc
842401 ggcgtggtcg gcggcgaatt tggcgtagat gtcggcggcg tggctgccca gcggggccgt
842461 cgcaccggtg gcggccaccg catccatcgc caggcccagg tccttgttca tcaacgcggt
842521 cgaaaacccg ggcttgaagt cgttgttggc cggtgaggtg ggcaccgggc ccggcaccgg
842581 gcaattggtg tgcaccgccc agcaattgcc ggtcgcgccg gtgatgacgt cgaacaacga
842641 ttgtgcggac agcccgagct tctcggccag cacgaacgcc tcggcgatcg cgatctgctg
842701 caccgccagc accatgttgt tgcacacctt ggcggcctgt ccggcaccgg cggcgccgca
842761 gtgaatgatc ttgcccgcca tgggctctag taccgggcgt gcccgccgta gcgtggactc
842821 gtcgccgccg accatgaatg ccagcgtcgc ggcggcggcg cccttcaccc cgccggagac
842881 cggcgcatcc agttggagca tgccgtgcga ttcggccagc gcgtgcacct cacgggcatc
842941 ggtgaccgag atcgtggagc tgtcgatgaa cagcgttgcc ggacgcgcgg cggccagcac
843001 gtcggtgtag cagcgccgga ccacctcgcc ggtgggcagc atggtgatga ccacgtcggc
843061 ctcggccacc gcttcgggcg cgctacgaaa caccgcgaca ccgtgcgcgg cggcgccgga
843121 cgccgccgtg ggtgccgggt cgaatccacg cacgacgtgg cccgcaccaa ccagattcgc
843181 cgacatcggc gcacccatgt tgcccaaacc taggaaggcg atggtcgtca tctgagcctc
843241 tctaaacggt ggcgcggaac cgcgcggcct cggcccgacc gatgaccagc cgcatgatct
843301 cgttggtccc ttccaggatg cgatgcaccc gcaggtcgcg gacgatcttc tccagaccat
843361 actcgcgcag atagccatag ccgccgtgca gctgcagggc ctggtcggcg acctcaaagc
843421 aggtgtcggt gacgtagcgc ttggccatcg cacacagctc gaccttgtcg gcgtcgtcgt
843481 catcgagcgc acttgcggcc cgccacaaca acattcgcga cgtctgcagc ccggtagcca
843541 tgtcggccag ggtaaaccgc acggtgggct cgtcgagcag cgatccgccg aaggcctgtc
843601 ggtcgcgaac gtaggcgccc gctttgtcaa aggcggcctg cgcgccaccc agcgagcatg
843661 ctgcgatatt gagccggccg ccgttgaggc cgctcatcgc gataccgaag ccggcgcctt
843721 cgccgtcggc gccgcccagc atggcctcgg cgggtacccg caccccgtcc agcaccacct
843781 gcgcggtggg ttgggcatgc caacccatct tcgcttcggg cgcgccgaaa ctcagccccg
843841 gtgtgccctt ttcgacgatg aacgccgaca cgccgcgcgg accctcggcg cccgtgcgcg
843901 ccatcaccac atacacgtcc gatgctgcgg ccccggaaat gaattgtttg acgccatcga
843961 gcacgtagtc gccgcctttt cctgagccgt gcctgacggc gcgggtgctc agtgcgccgg
844021 catcggatcc ggcgcccggt tcggtcaggc agtagctggc gatgacgccc atggtggcca
844081 gtcgcggaat ccagtccttg cgttgctcgt cggtgccgaa gctgtcaatc atccacgcgc
844141 acatgttgtg gatggacaaa aacgcggcgg tcaccgggtc ggcgatcgcc aactgctcga
844201 agatgcgcac gccgtcgagc cggcgcagcc cactgccgcc gacgtcgtcg cggcaataga
844261 tcgcggccat gccgagttcg gccgcttccc gcaacacgtc caccggaaag tgtttggcgg
844321 catcccattc cagggcgtgc ggagccaggc gtttgccggc gaaggcggcc gccgtctcga
844381 cgatcacccg ttcgtcgtcg ttaaggacaa acatgacacg ctaactcatt gtggggatga
844441 cgaattcggc accgtccttg atgcctgacg gccatcgcga cgtgacggtc ttgaccttgg
844501 tgtagaactg gattgccgcc gggccgtgct ggttgaggtc gccgaagccg gagcgcttcc
844561 agccgccgaa agtgtggtag gccaccggca ccgggatcgg cacgttgacg ccgaccatgc
844621 ccacctgcac ccgggagacg aagtcgcggg ccgcgtcgcc gtcgcgggtg aagatcgcca
844681 ccccgttgcc gtattcgtgc tccgacggca gccgcaacgc ctcttcgtag tcgcgggcgc
844741 gaaccatgca caacaccggc ccgaagattt cgtcggtgta gatcgacatg tgggcagcga
844801 catggtcgaa cagggtcggc ccgatgaaga agccgccctc caggttcgca tcgccttcag
844861 gcagcccaaa ggtcaggtcg tcgctggcgc ggtcgcggcc gtcaacgacc agctcggcac
844921 cggcggccac accctggccg atgtagtcgc gcacccgcgc cagcgccgcc ccggtgacca
844981 gcgggccgta gtccgccttg gggtccaggc tgtgtcccac ccgcaagtta ttgatccgct
845041 cgatcagcct ggcgcgcaac cgctccgcgg tctgatcgcc caccggcacg gcgacgctga
845101 tcgccatgca gcgttcgccg gcgctgccgt atccggcgcc gatcagtgcg tccacggcct
845161 gatccaggtc cgcgtcgggc atcacgatca tgtggttctt ggcaccgccg aaacactgcg
845221 cccgcttgcc ggtggcggcg gcaccagcgt agatgtactg agcgatatcc gagctgccga
845281 cgaagccgac ggccttgatg tcggggtggt gcaggatggc gtcgacggcc tccttgtcgc
845341 cgtgcaccac ctggaacacg cccgccggca ggcccgcctc gatgaacagc tcggccagcc
845401 tcaccggaac cgacgggtcg cgctcacttg gcttgagcac gaaggcgttg ccgcacgcta
845461 gggccgggcc ggccttccac agcggaatca tcgccgggaa gttgaacggg gtgatccccg
845521 cgaccacacc caggggctgc cgcagcgaat agacgtcgat gccggggccg gcaccctcgg
845581 tgtactcgcc cttgagcagg tggggaatgc ccaggcagaa ctcgattacc tcgatgccgc
845641 gctggacgtc gccgcgggcg tcggccagcg ttttgccgtg ctcacgcgac aacagctcgg
845701 ccaactcgtc gatggtgtcg ttgaccagtt cgataaaccg catcaacacc cgggcacggc
845761 gctggggatt ccatgcggcc cagccctttt gggcctcgac cgcggaggcc acggccgcgt
845821 cgatgtctga cttgccggcc atcggtacct tcgcctggat ctggccggtg ttggggtcga
845881 agacgtcggc cgagcgcgtg gactggccgg cggtgcgttg tccgtcgatg aaatgtgaaa
845941 tctgtgtggt catggttgtc ctgtgcaagc cggtggcggc ggggaatccc gatacttgga
846001 tatcctagta actgtggcgg atggctcgca aggcgaccga gccgacagcg tcctagcggg
846061 agacgcttgg atgctcgttg cattttggcc gatacccgca tctgttccgg cgctgcgctc
846121 catcatggct agtacgcgac aacacccggg ggtaagcgat gtcatttgtg atcgtggcgc
846181 gggacgcgtt ggcggcggcc gcggcggatc tagcgcagat cggttcggca gtgaatgcgg
846241 gcaatctggc cgcagccaat ccgacgaccg ctgtggcggc ggcggccgcc gacgaggtat
846301 cggcggcact cgcggcgctg ttcggcgcgc atgcccggga gtatcaggcg gcggcggcgc
846361 aggcagcggc gtatcacgag cagtttgtgc accgattgag cgcggcagcg acatcgtatg
846421 cggttaccga ggtgaccatc gcgacgtcgc tccggggggc gctgggctcg gcgcccgcgt
846481 ccgtttccga cgggttccaa gcgttcgtct atggtccgat tcacgcgacc ggccagcaat
846541 ggatcaacag cccggtcggc gaggcgctcg ccccgattgt caatgcgccg acaaacgtgc
846601 tgctcggccg cgatctgatc ggcaacggcg tcaccgggac ggcggcagct cccaacggtg
846661 gccccggcgg tttgctattc ggtgacggtg gggccggcta taccggcggt aacggtggga
846721 gtgccgggtt aatcggcaac gggggtaccg gtggcgccgg ctttgccggc ggagtgggcg
846781 gcatgggcgg caccggcggc tggttgatgg gcaacggcgg catgggtggc gcgggcggtg
846841 tcggcggtaa cggcggcgcc gggggccagg cgctgttgtt cggcaacggc ggcctgggcg
846901 gagccggcgg ggctggcggg gtcgatgggg ctatcggtcg tggcgggtgg ttcatcggta
846961 ccggcggcat ggccacgatc ggtggtggcg gcaacgggca gtcgatcgtc atcgacttcg
847021 tgcggcacgg ccagacgccg ggcaacgccg caatgttgat cgacacggcg gtgcccggac
847081 ccggactcac cgcgctgggc cagcaacagg cgcaggccat cgccaacgcg ctcgcggcca
847141 agggccccta tgccgggatc ttcgactcgc agttgatcag aacgcagcag accgccgcgc
847201 cgttggcgaa cttgctgggg atggccccgc aggtattgcc cgggctcaac gagatccatg
847261 ccggcatctt cgaggacctg ccgcagatca gccccgcggg cctgctgtat ctcgtcggcc
847321 cgatcgcctg gacgctcgga tttcccatcg tgccgatgct ggccccgggc tccaccgacg
847381 tcaacgggat cgtcttcaac cgagccttta ccggtgcggt tcaaacgatc tacgacgctt
847441 ccttggccaa tccggtcgtg gccgcagacg gcaacatcac gtcggtcgct tactccagcg
847501 cattcaccat cggggtcggg acgatgatga acgtcgacaa tccccatccg ctactgctgc
847561 tcacccaccc ggtgcccaac accggcgccg tcgtggtaca gggcaatccc gagggcggct
847621 ggacgctggt cagctgggac gggatacccg tcgggccggc gtcgctgccg accgcgttat
847681 tcgtcgacgt gcgcgagctg atcacggcgc cgcaatatgc ggcctacgac atttgggagt
847741 ccctgttcac cggcgatccg gcggcggtca tcaacgcggt gcgagacggt gccgatgagg
847801 tcggcgcggc tgtggtccag ttcccacatg cggtggctga cgacgtgatc gacgctacgg
847861 gccaccccta tctaagcggc ctgccgatcg gtctgcccag cctgatccca tgaccgcgag
847921 cgaccaatag gtccccacat ggcccggagg ccgctgccag cattgacccg acgatgccgg
847981 cccgcaggct tccctgatcg tgcggaacct gctcggccgt gcatgggaca tccagatcgg
848041 attgcctccg ggtacggcgt acgccggacc cggtcgccgg gacgataccg ggctagtgtt
848101 agctagcggt ggaaaaagcc cgacacgaaa tcgatcgaat taaagccacc agaatcctgc
848161 tttccagagt tcccgaaacc cgatgtggcg ctgttgttgt cgggattggc ttcaagatta
848221 ccgaagcccg actgtagaaa acccgtattg ccaaagcccg acatgaatcc actgaacagg
848281 ccggttccct tgttcccgaa acccgatgtt acactaaccg aattgttgta acccgttacc
848341 gattggcccg agttggcgaa gcccgagatt tgtaaattac caacgttttg ggcgccggag
848401 tttcccctac cagaattatt gaaacccgaa tttccactgc cggcgtttcc gaatcccgag
848461 ttttcgccca gcccatcggt agtattgccg aaaccggtgt tcaggttgcc cgcgttaaag
848521 ccgcccgtgt tgatattgcc agaatttgcg aagccggtgt tcgtcaggcc agagttcaag
848581 aaaccagaat tagcgtctcc tccgttgaag ctgcctgagt tgaatgcacc cgagttgaag
848641 ctaccggtgt taatgatgcc gccgttgaag ttgccggtgt tgaaatcgcc cgcgttccct
848701 atgccggtat tggcctgacc tgagttgcca aagccagtgt tgacgcttaa cgcgttcccg
848761 aagccggtgt tgataaagcc ggagtttccg aagccggtgt tgatgttgcc tgagttggct
848821 acgcccgtgt tggtgacgcc cgagttgccc acgccgaagt tgccgctgcc cgagttgaag
848881 aagccgatgt tcccggtgcc cgagttacca aatcctatat taccgctacc ggaattcagt
848941 ccgccaaagc cgatctgatt gctgccggtt aacccaatgc cgatattatt gttgccggtg
849001 ttcccgaagc cgaagttgta gctgccgctg ttcccgaagc caacgttgcc gtcgcctacg
849061 tttcccagac cgatatttgc gttgcccgtg ttaccaccgc cgaagtttcc attgccaccg
849121 ttgccaatcc cgacattccc attgccgggg gtgggcacgg cgggggaact catgtttgga
849181 cctgcatttc cgataccaat gttggcattg ccaaagttcc cgaagccgaa gttgttgtcg
849241 ccagagttgc cacccccgac gttcgcatta ccgatgttgc cgctacccac gttaaagctg
849301 gacggtccga tgccaacgtt tccgtttccg ctacccaggt tgaagttgcc gatgttgccg
849361 ctacccacgt tgaagctgga aatctggccg tggaaggcgc ttccgtttcc gccgccaaag
849421 ttggcgttac cgaggtttcc attacccagg ttgtaatcgc cggtattacc attgccgaca
849481 ttgaggttgc cgatattgcc gacacccaaa ttgatgtttg gcaacgccgg ctgccacgac
849541 gccagctgtg ccgctgccgc cgaggatgcg gcatggtagc cggccatcac cgccacgtct
849601 tgtgcccaca tctgctcgta ggtggattcc atggccgcta tggccggcgc gttttgcccg
849661 aacacattcg acaccgccaa caaccacgtc cgaacacgat tggcctgcac caccgccgga
849721 tgcaccacgc cggccagcgc ctcctcaaat gcacccgccg ccgcccgagc ctgccgcgct
849781 gccagctcgg cctgggctcc agccgcggtc aaccagctcg catacggccc cgcggcattc
849841 gccatcgcgg ccgacgccgg tccctgccaa gcgccgccgg ccaactccga cgtcaccgac
849901 ccgaacgacg acgccgccgc gtgcaactcc tcggccaacc cgtcccaggc ccccgccgcc
849961 gccaatagtg gccgtgaccc cgcacccaga tacatccgta gcgaattggt ctccggaggc
850021 aaccacgcga aaccgaccat cacggccccc tcacaccatt gacaaaccag gacgcctcga
850081 gcctaactac acaacgcgaa gggattggga cttctatcgg aattgcgccg cgtgcactgg
850141 ccgccggcct ttccccgcca gcctcggtgt ttcatgccgc ttgccgtggt ctgccacctg
850201 cgagttcgca tttgtgcaga gtcccgtcgg gagttgtcaa aactaaaacg ggcgatcttg
850261 atcgcatcgg aagcgcgaga ttgcgccctg agctgcgcct tcgtggagcc cccggtcagg
850321 attgaacgga cgaccgctcg cttataaggc tgttccggta ccgatcctta agccatcgag
850381 gccctcggcc tcatagcggg ccaaccaggt atgcagcgtc tgccgcgaca ccccaacttt
850441 ctcggcaacc tgcgagatcg acaacccgtc gctgatcacc gccaacacgg cttgataccg
850501 ctgttctgcc acactcaact ccttcatcga aggagtgtca aggatcagcc gaaccaactg
850561 tcaagcatca gccgaaacat cgtcaggcat cacccgaacc caaaacgtca agcatcagcc
850621 gaggtactac acgaacgctt gagccccctg tcaggattga actgacgacc gctcgcttac
850681 aaggcgagtg ctctaccact gagctaagga ggccgatgaa atcgctgtga gtctagccgc
850741 tcactcgctg tcgacgacgc gttgcgaacg caccgaccgc gacgacgagc ggcgcgcggg
850801 acggcgcccg ggcagtggaa tgcgctcggc gatgctgctc agcgggttga ccaccatggt
850861 aagtgcgatc acagcgtctt gcagcgtcgc gatggccggc tcgagcgcct ccatcccggg
850921 tgtcagccgc gccaacgtgt cggcgacgtc ggcgagctgt tcgagcggtc cgtccttggc
850981 cgttatcttg tcgatcagtc cgccttcggc cagcagccgg tcggccagcc cgtcttcgga
851041 gagcacccgc tcgataagtc cgtcctcggc gagcagctgg tcggccagtc cgcccggttg
851101 cagcgcgcgc tgcatggcgc cgccttcagc ggtcaggcgg tcgagtaagc cgccgggctg
851161 ggtcagcagg tcgaccaccc cgccgggccg cagcatccgg tccatcggcc cgttgggcgc
851221 gatggcgcgt cccagcggca tatcgtcgtc caatagcctg gccagccggt tggcgcgggc
851281 aatcgtgtca tcgattccca gcatgttggc cattgaggtc gacccgcttg cgccgccggc
851341 atcacccaac gcttgtttgg ccatgtcaac cgccgcgccg gccatgttca aaccggtgtc
851401 ggcggcggcg agccccgctc gtgcgggcca ggtcgcaata cccacgaggg tttggccgag
851461 gttcattctg cgagtgtatt cacggcgcgc cgtggattga gcggcaacgg tccaagctga
851521 tttggcgatt cctggcagac tgttagcaga ctactggcaa cgagctttca ggaattacac
851581 aatgactgtg aaggtaacgt tcaaccaatg cggaaagggg ttgatctcgt gacggcggga
851641 accccaggcg aaaacaccac accggaggct cgtgtcctcg tggtcgatga tgaggccaac
851701 atcgttgaac tgctgtcggt gagcctcaag ttccagggct ttgaagtcta caccgcgacc
851761 aacggggcac aggcgctgga tcgggcccgg gaaacccggc cggacgcggt gatcctcgat
851821 gtgatgatgc ccgggatgga cggctttggg gtgctgcgcc ggctgcgcgc cgacggcatc
851881 gatgccccgg cgttgttcct gacggcccgt gactcgctac aggacaagat cgcgggtctg
851941 accctgggtg gtgacgacta tgtgacaaag cccttcagtt tggaggaggt cgtggccagg
852001 ctgcgggtca tcctgcgacg cgcgggcaag ggcaacaagg aaccacgtaa tgttcgactg
852061 acgttcgccg atatcgagct cgacgaggag acccacgaag tgtggaaggc gggccaaccg
852121 gtgtcgctgt cgcccaccga attcaccctg ctgcgctatt tcgtgatcaa cgcgggcacc
852181 gtgctgagca agcctaagat tctcgaccac gtttggcgct acgacttcgg tggtgatgtc
852241 aacgtcgtcg agtcctacgt gtcgtatctg cgccgcaaga tcgacactgg ggagaagcgg
852301 ctgctgcaca cgctgcgcgg ggtgggctac gtactgcggg agcctcgatg agtcttggta
852361 gttaatcgga tcggcagccc gaggagaacg cggcaatggc cagacacctt cgaggaaggc
852421 tgcccctacg ggtacgcctg gtcgcagcca cgctgatcct ggtggccact ggacttgtgg
852481 cctcggggat cgcggtcacc tcgatgttgc agcaccggct gaccagccgg atcgatcggg
852541 tgttgctcga ggaagcccaa atctgggcgc agatcacgct gcccttggcg ccggacccct
852601 accctggtca taaccccgat cggccgccgt cgaggttcta cgttcgggtg atcagccccg
852661 acggccagag ctatacggca ctcaacgaca acactgccat accggcggtg cccgccaaca
852721 atgatgtcgg ccggcacccg acgacgctgc catcgatcgg cggatccaag actttatggc
852781 gcgcggtctc ggtgcgcgcg tcggatggct acttgaccac cgtcgccatt gatctggccg
852841 acgtccggag caccgtgcgg tcactggtgc tgttgcaggt cggcataggc agtgcggtgc
852901 tggttgtccc cggggtggcg ggctacgctg tggttcgccg cagcctgcgg ccgctggcag
852961 aattcgagca gacggccgcg gcgatcggcg cggggcagct ggatcgccgg gtcccgcagt
853021 ggcatccgcg aactgaggtc ggccggcttt cgttggcgct caacggaatg ctggcacaaa
853081 ttcagcgggc ggtggcgtcc gcggaatctt ccgccgaaaa ggcccgggat tcagaggacc
853141 ggatgcgaca gttcatcacc gacgccagcc atgaactgcg taccccgttg accactatcc
853201 gcggcttcgc ggagctgtac cgacaaggag ccgcccgcga cgtgggcatg ctgctgtcgc
853261 ggattgagag cgaagcgagc cggatggggc tgctggtgga cgatttgctg ctgcttgccc
853321 ggctagatgc gcaccggccg ttggaactgt gccgggtgga cctgctggcg ctggccagtg
853381 atgccgcgca cgacgcgcgg gcgatggacc ccaaacgcag gatcaccctg gaggtccttg
853441 acggccccgg caccccggag gtcctcggcg acgaatcgcg gcttcggcag gtgctgcgca
853501 atctcgttgc aaatgccata cagcacaccc cggaaagcgc cgacgtcacc gtgcgagtcg
853561 gcaccgaggg cgacgacgcc atcctcgagg tcgccgatga cggtccgggc atgagtcagg
853621 aggatgcgct gcgggtgttc gagcggttct atcgcgccga ctcgtcgcgg gcgcgcgcca
853681 gcggcgggac cggactgggg ttgtcgatcg tcgactcttt ggtggcggcc catggcggag
853741 cggtcaccgt gacgaccgcg ctcggggagg gttgctgctt tcgtgtctcg ctgccgcgcg
853801 tcagtgacgt ggaccagctg agcctcacgc cagttgtgcc agggccgccc tgatcttggc
853861 ctgcgcttcg tccagcgatc ccggtgaggg gttgcggtcg acgttggcaa agccgaaatc
853921 actgaggctg cgggtgggaa acacgtggat gtgtaggtgg ggcacttcca gcccggcaat
853981 gatcatcccg gcgcgttggg ttgaaaacgc ccggcacacg gccttgccga tcagctggct
854041 caccgacatg acgcggccaa ataacgcggg atccacgttt tgccagtggt cgatttcggc
854101 gcgtggcacc accaaggtgt ggccttgcgt catcggctca atcgtcaaga acgccacgac
854161 gtcgtcgtcc tcgtagacga aacggccggg cagttcacgg ttgatgatct tggtgaagat
854221 cgacacccgt tgagcatatg acgtcgcaac ggcccccccc caggtttcat tcctggttac
854281 cgaaggtcat catgtcgagg ttccagtacc cacgcatgtt ggtgatcaaa ccggccttat
854341 tcacccggta ggtgaacacg ccgcggacct cactggtaaa gccgccgtca aactcgctgt
854401 gcaacaccag aatgtgggcg atctcgtccg gtgagctgga cgggaacgtc tcctcgcagg
854461 tgaccgtcaa ccgattggcc gcaatgtgtg tgtcgaagaa ggcgccgacg gcctccttac
854521 ctttgatgcc gctgccatcg ggattggtga cggacttgcc gatcggatcc tcgatgacga
854581 cgtcgtcggc catcagcgcc agccagccct cccggtcgtg ggcttggacg caccgccacg
854641 acgactgcga cgcgatcagg gccggggatt gggtcgtttg ggtcatggct atctccggct
854701 agcggtcgtc gtccgtgtac cggatcacgc cgcgaatgtt cttgccgttc agcatgtcct
854761 ggtatccgtc gttgatctgc tccagcttgt acgcagtggt caccatgtcg tcgaggttga
854821 gtttgccggc cttatacatc gacaacagct tcggaatgtc gtagtgcggg ttgccgccgc
854881 cgaagatggt gccctggatg ttcttttgca gcagggtcaa catcgcgagg ttcagcgtca
854941 cctgggtgtc gaccaggctg ccgatggccg tcagcacgca ggtgccgccc ttggccgtga
855001 tggtcagata gctgtcgacg tcggcgccat cgagcttgcc gacggtgatg atcaccttct
855061 gcgccatcag gccgtaggtg acctcggcaa tgcccatcag cgcggcgttg atgtccgggt
855121 agacgtgggt ggcaccgaat ttcagagcct gatcacgttt ccattccacc ggctccaccg
855181 cgaagacgta gcgggcgccc gcgctgaccg cgccctgcaa cgccgccatg ccgaccccac
855241 ccaagccgac gatggccacg tcgtcgcccg gccggacgtc ggccgtgcgg accgccgaac
855301 catagccggt ggtgacgccg caaccaacca ggcaggcgac ttcgaagggc accgacgggt
855361 cgatcttcac caccgagctg cggtgcacca ccatgtacgg tgaaaacgtt ccgagcaggg
855421 tcatcgggta gacgttctgg ccgcgagcct gaatccggaa ggagccgtcc gtcacagatt
855481 ccccggcgag cagccccgcc cccaggtcgc acagattccg cattccagcc tggcaggacg
855541 gacacttgcc gcaggacggg atgaatgcca acaccacgtg atcgcccggg gcgaagtcgt
855601 cgactcccgg gccgacctcg gtgacgatgc ccgcgccctc gtgtccgccc agaacgggaa
855661 agcccgccat cgggatgtcg cccgtcacca ggtgatggtc ggagcggcac atcccagccg
855721 cttccatctg gatcttgact tcgtccttgc gcgggtcgcc gatttcgatc tcttcgacgg
855781 accatggctg gttgaactcc cagatcagtg cgcccttggt cttcaccgca aacctgcttt
855841 catcgttgaa cttcggctac gagtggtccc tagcctcggc cggaacgccg actggctgag
855901 tgtaggtcaa cggcgctagg gcgtttacca cagtggcacc ggcgtcttgc cgagcgggta
855961 atagcccggc actttgttgc ccgacacggc gcgttcgatg cgcttctgca tgcctggcga
856021 tagcttgccg gccttgatca attccaggta gagcgcggaa acatgaccga agtcgaagaa
856081 atcgcgttgc cagttccatt tcccgccgcc ggcataccgg aaccagctgc cgccaatgcc
856141 gtacacctcc tgctcggcgc cattggcgtc ggtggcaacc tgtttccaga acccaaccac
856201 ctcgccctgt ttctcgtcga tgacgacccg ttgatagggg tagcgccagc cctgcaggcc
856261 gtccatttcc tggcccagcg caatgtcgcg gatctcgtcg atgccgacgc acatcacgtc
856321 ctcgttggga ccgacgttcc agccgtaggt ggcgtcgtcg gtgtagaagt cggccagcaa
856381 cgtccagtcg ccgcgccgct ccgccgtacg gttggcctgt aaccagcggt gaaccacatc
856441 ttcgagttcg tcgcgaggat agccggccac ggttactctc ccgtttctcg gatggacagt
856501 gcctgggtgg gacaggccca cacggcatgc ttgatcacgc cgcgggcttc ctcgggcggc
856561 tcggggtcga ggatttcgac ctggccgcgc ttgggcaccc ggaaatactc gggtgcctcc
856621 agctcgcaca tcgcgtgtcc ttggcacaga tcccggtcgg cttcgactcg atagcccatc
856681 gttaaactcc cgttcgccgg cggtagcgca cgcaagcggg ctgggccaac tgcaccacca
856741 tcttcgaatg gtcgttacga tagctttctg gcggttgcgc catctcaaac tcatactcgc
856801 gcaacaacac cgagaagatc gctttgatct gcatgatggc gaacgccgcc cccacgcaac
856861 gatgccggcc ggcgccgaac ggaatccacg tccagcggtt gagcagatct tcctggcgcg
856921 gctgctcgta tcgtgctggc acgaagtcgt ggggatcggg gaagtcttcg gggatccggt
856981 tggagatcgc cggggaggcc gccaccagat cgccctcatg aatccggtgg ccttgcacct
857041 cgaactcgcc cttggccact cgcatgagga tgatcagcgg agggtgcagg cgcagcgtct
857101 ctttcagcac gttttccagc tgcggaatct ggcgcagcgc atggaaactc accgatcggc
857161 cgtcgccgta cagctcgtcg agttcgtcga tcacggccgc gtaggcgtcg cgatggcgca
857221 tcaactcgat cagcgtccac gaagccgtac ccgagctggt gtgatggccg gcgaacatca
857281 tcgagatgaa catgccggtg atctcgtcgg ccgagaaccg gggagtgccg gtctcagcct
857341 tgacggcgat gagcacgtcg agcatgtcac ggtcgctctt gtcggtgggt gggttggcga
857401 tccggccgtt catgatgtcc gcaaccagtg ccaccagacc attgcgggct tcgtcgcggc
857461 gacggaagct ctcgatcggc agatacgggt cgacgtaggc tagtgggtcg gtgccgcgct
857521 ccaactcgtg atagagcttg gcgaatcgcc cgtcgagctg gtcgcggaac ttcttgccga
857581 tcaggcaggc cgaggaggtg tagatggtca gctcggcgaa gaagtccagc agatcgatct
857641 cgccggcctc accccagtcg gcgatcatcc gtcggacttg atcttcgatg gtggcagcgt
857701 ggcccttcat ctgctcgccg cgtagcgcgg cattgtgcag catctcttta cgccgttccg
857761 ggctggcgtc gaacaccacg ccctcgccga agatcggcgt catgaacggg tatgccttgg
857821 cctggtccag gtcgtcgtcg cccgcccgga agaagaattc gttggcgtgc gagccggaca
857881 gcagcacgac ctgcttcccg gccagctgga aggtaccgac gtctccgcat tcgtcgcgga
857941 cccgttgcat cagcccgatc ggatcggtgc ggaactcctc gaggtggccg tgttcgtcgt
858001 ggccacccga aacccggggt agtgcaacag cgctcattag cccggcatcc cctcttcgcc
858061 cagtactagc ttctgacggt gcgcgggcgc atccctcagc ggggcctccg gttgaatctc
858121 catgttcacc acgacacacc cgcgcggcgt ttctgcgacg aacgcgatag cgcgtgccag
858181 gtcgctgggt cgcaagaagt agttgtgccg ggcctgcccc cactttgccc agtccgccag
858241 cattgggccg acttgttcgg ccgacagctg ccagcccata ccggtcagcg tgggtcccgg
858301 atgcacgatc gatgcgcgaa caccggtgcc ttccaactcc atctgcaggt tggtgaccat
858361 agcggccaga ccggccttgg cggcgccgta ggcacccata tgcgggcgtt ggcgcaggcc
858421 cacatcggat ccgacgaaga tgaggtcacc tcgccggcgt gccaccatgg ccggtagcac
858481 ggccgtggcc agccggttgg caccgaccag gtgtatctga acctgctctg caaaggcctc
858541 ggtgctgacc tcgtgcagct gtcccgggag catgtcgcct gcactggaca ccagcagttc
858601 gacctcgccg agtgcctcga ccgtttgcgc cacaaacgat ttcaccgact cgggatcggt
858661 cacgtcgagg gggaaggcta ccgcctcgcc accgtcggcg cggattttgt cgaccagctc
858721 ggccaacttg tccatgcggc gggcccccaa ggcgaccgga aacccgcggc cggcgagttc
858781 ggttgcggtg gccgcgccga tgcccgacga tgcgccggcg acgacggtgg tccgccgggc
858841 ggggtgaggt tcgaagcgtg gcattacctg gcctgcacgc tgatcggcag atgggcaaat
858901 ccgcgcacgt tgctggaatg gacgcgcacg acgttgtcgt cgtcgacttc gtagttgcgg
858961 atccgacgca gcagcgcgcc cagggccacc cgggcttcca tccgggccag gtgagccccc
859021 agacagaagt gggcaccgct gccgaaactg actagtttgc agccgatttc gcggccgatg
859081 cgatagtcgt ccgggtcgtc gaacacccgg tcgtcacggt tggccgatcc cggtagcagc
859141 agcaacacct caccctcggg gatcgtggtg tcgtacaacg tgagatcgtg cgcgacggtg
859201 cgggccagaa tctggctgga cgtgtcgtag cgcagggttt cctccaccca catcggaatc
859261 cgggagtggt cggcgaatac gcgggccagc tggccagggt ggtgggcggc ccagtagacg
859321 gcattggcca gtagcttggt ggtggtctcg ttgccggcga tcaccatgag aaacaggaac
859381 gccatgattt cctggtcgga aagccggtcg ccgtcgagct cggctgccag cagtgccgac
859441 gtcagattgt tcgcgggccg ccgccggaat tccgcgatca ggtcagcgta atatctcatc
859501 agctcgatcg acgccgccat cgccggcggg ggcacatcgg ccacgccgtc ctcgcggtgc
859561 agcaccgcat cggccagcgc gcggatgcgg gcccggtcgg tgtcgggcac gcctatcagc
859621 tctgaaatca catccatcgg cagcttgcca gcgaattctg ctacgaaatc gaaactttcg
859681 gtttgcaggg ccgaatccag gtgaatgcgg gcaagttcga gcacctgcgg ctcgagttca
859741 cggatccgcc gtggggtgaa gcccttggac accaaggtac gcatccgcag atgtgcgggg
859801 tcgtccatgg ccagcatcga cattacccgg tacgcctcag aagtgcgtga ggacggatcc
859861 agggataccc cataggcatt cgacaacgcc gtgctgtccc ggaagccttg cagcacgtcg
859921 tggtgccgcg acaccgccca gaaattgcgt tcctcgttac ggtacagcgg ggcctcgtcc
859981 cgcagccgac gataatacgg gtacgggtct tcgtgaaagt cgtagtcgta ggggtccagg
860041 accagttcgg ggtcaccgac gcggacggtc attcgctgcc accagtgctc ggctcgttag
860101 ctccggccaa gatcaggccc accacgtacc cgagtcgatc ggcgatctcg tggtaggtga
860161 aggtgccgct gccggcctgt acgagcgctc cgaagaacgc catctcgagt gcgaacacgg
860221 taccgggatc ggcgccaggt ccgatcgccg atgtgatgcg gcggtggatc tcggcgccga
860281 ttcggtcgcg caccgcacgc accgcggggt cggcgccgcc gtcgagcagc gccgccgtgc
860341 acgccgcgcc gatttcgggt tcgtcggcaa ccaccagcgc caggtgtcgc aacgagctcg
860401 tcacccggat aggcatcggg acgttgacgt cggtgacgca ggggacctgg cggaccaggt
860461 cgaggtagac ctcggcgatc agatggttct tcgacgagaa gtatgtgtag gccgtcgccg
860521 gggctacctt ggcgcgggcc gccaccaggc gcaccgtcag gtcggcgtat gacttctccc
860581 gcagggtcgc catggcggca gctagcacct tgcggaaggt tgcctgctgg cggcggttgc
860641 gtgacaccgc ttcggcgtgg ggttcggttt ggcgctgggc cggggtggta accagtacat
860701 cgctggacac atgtccaagc tatcggatgg tcgcggcagg aggcaagcca gtctgctaaa
860761 catgcagcta acatgggact gtccgcgacg cgacgtggcc cctggtgcat cggtcaggac
860821 ggtgtagcgg ccttgcggat acggtctcga tgaggcaata tcggacaagt gtccaatcga
860881 tgatgagagt cggagaagtt gggagcggta gatggccctg tggggcgacg gaattagtgc
860941 gctgctcatc gacggcaaac tatcggacgg ccgtgcgggc accttcccga cggtcaatcc
861001 ggccaccgag gaagtgctgg gagtcgccgc cgacgccgat gccgaggaca tgggccgcgc
861061 catcgaggcc gcgcggcggg cgttcgactc gaccgactgg tcccgcaata ccgaacttcg
861121 ggtgcggtgt gttcggcaac tgcgcgacgc aatgcaacag cacgtcgaag aactacgcga
861181 actgacgatc tccgaggtgg gcgcgccgcg gatgctcacc gccagcgccc agctggaagg
861241 cccggtcggg gatctatcgt ttgcggcgga cacggccgag tcctacccgt ggaagcagga
861301 cctcggcgag gcatcgccgt tgggcatcgc cacccggcgc accctcgcac gggaggccgt
861361 cggtgtcgtc ggcgccatca ccccgtggaa cttcccgcac cagatcaatc tcgccaagct
861421 aggtccggcg ctagccgcgg gtaacaccgt cgttttaaag ccggcgcctg acacaccgtg
861481 gtgcgcagca gcgctcgggg aaatcatcgt cgagcacacc gacttcccac cgggcgttgt
861541 caacatcgtc acctccagca gtcacgcttt gggggcgctg ttggccaaag accctcgggt
861601 ggacatgatt tcgttcaccg gttctactgc gaccggccgt gccgtaatgg ccgatgccgc
861661 ggccaccatc aaaaaggttt ttctggaact gggtggcaag tcggcgttcg tcgtgctcga
861721 cgacgctgac ctagccgctg ccagcgcggt atcggcgttc tcggcttgca tgcacgccgg
861781 gcaggggtgc gcaatcacga cccggctggt ggtgccacgg gcccgttatg aagaggcggt
861841 tgccatcgcg gcagccacca tgtcgtcgat caggcccggc gatcccaacg accccggaac
861901 cgtttgcggg ccgttgattt cggcccgaca acgggatcgt gtgcagggct acctcgacct
861961 ggcggtcgcc gaaggcggaa ggttcgcatg cggtggcgcg cggccggcgg atagagaggt
862021 cggtttctac atcgagccca cggtcatcgc agggttgacc aatgacgcca gagtcgcccg
862081 agaggagatc ttcggaccgg tgctcacggt gattgcccac gacggtgacg atgatgcggt
862141 gcgcatcgcc aacgactcgc catacggctt gtcgggcacc gtgtatggcg ccgacccgca
862201 gcgcgccgcg aggattgcct cgcggctgcg ggtaggcacc gtcaacgtca atgggggtgt
862261 ctggtactgc gccgacgcgc cgttcggcgg ctacaagcaa tccggtatcg gacgcgagat
862321 gggtctcctc ggcttcgagg agtacttaga agccaaactc attgctaccg ctgcaaatta
862381 gctagcgggt tgacagcgca gaaaggaagc catgttcgac agcaaggtgg ctatcgtcac
862441 cggggctgcc cagggtatcg ggcaggccta cgctcaggcg ttggcccgcg aaggtgcctc
862501 ggtggtcgtc gctgacatca acgccgacgg tgccgcggcg gtagccaagc agattgtcgc
862561 cgacggcggt actgcgattc atgtgcccgt tgacgtgtcc gacgaggatt ccgctaaagc
862621 catggtcgac cgcgccgtcg gtgctttcgg cggcatcgac tatctggtga acaatgcggc
862681 gatctacggt ggcatgaagc tcgatctgtt gttgaccgtg ccgttggact actacaagaa
862741 attcatgagc gtcaaccacg acggcgtgct ggtgtgtacc cgcgcggtgt acaagcacat
862801 ggccaaacgg ggcggcggcg cgattgtcaa ccagtcctcg accgcggcct ggctgtattc
862861 caacttctac ggcctggcca aggtcggtgt caacgggctg acgcagcagc tggcccgcga
862921 gctgggcgga atgaagataa ggatcaatgc gatcgcaccc ggaccgatcg acaccgaagc
862981 tacccgcacc gtcacccccg cagagctggt caagaacatg gtgcagacca tcccgctgtc
863041 gcggatgggt acaccggagg atctggtggg catgtgcctg ttcctgctgt cggattcggc
863101 atcgtggatc accgggcaga tcttcaatgt cgatggcgga cagatcatcc ggtcatgacc
863161 ggcgccggcg ccgatgcaga gcggggcgat gaggtggggg cacgccccca caagtgggag
863221 gtacccccat ccgctggcgg gggagagcgg cgctcatgac cgctcacccg gagacaccac
863281 gcctgggata tatcggcttg ggtaatcaag gcgcgccgat ggctaagcgt ctgctcgatt
863341 ggcctggcgg actgaccgtt ttcgatgtgc gggtcgaggc catggcaccg ttcgtcgagg
863401 gcggcgccac cgcagcggca agcgtctccg acgtcgccga agccgacatc atcagcatca
863461 ccgtgttcga cgacgcgcag gtgagttcgg tgatcaccgc cgacaacgga ctggcgacgc
863521 acgccaagcc cggcactatt gtcgcgattc actccaccat cgccgacacg acagcagtcg
863581 atctggccga aaagctcaag ccgcagggga tccacatcgt ggatgcaccg gtcagcggcg
863641 gcgcggcggc ggccgccaag ggtgagttgg ccgtgatggt cggcgctgac gacgaggcgt
863701 tccagcggat taaagagcca ttttcgaggt gggcttcgct gttgattcat gccggggaac
863761 cgggcgctgg cacccggatg aaactggcgc gcaacatgtt gactttcgtc tcttatgccg
863821 ccgccgccga ggcgcagcgg ctggccgaag cctgtggctt agacctcgtg gcgctcggga
863881 aggtggtgcg gcacagcgac tcattcaccg gcggcgcggg agcgatcatg ttccgcaaca
863941 ccactgcgcc gatggagccg gctgacccgc tgcggccgtt gttggagcac acccgcggcc
864001 tgggtgagaa agacctgagt ctggcgttgg ccctgggcga ggtggtatcg gtcgacctgc
864061 cgctggccca gctggcgctg caacggctgg ccgccggcct cggggtaccg cacccggaca
864121 ccgagccagc aaaggagaca tgatggacga gctgcgccgc accggcctgg acaaaatgaa
864181 cgaggtttac gcctgggaca tgcccgacat gccaggtgag ttttttgccc tgaccgtcga
864241 tcacctattc ggcaggatct ggacccgtcc cggcctgtcc atgcgggacc ggcggatggc
864301 cgtgatcgcg gtgctgaccg ctcaaggcca gtcggatctg ctcgaggtcc aagtcaacgc
864361 cgtcctgcat aacgacgaac tcaccataga cgagctgcgt gaactcgctg tgttcattac
864421 ccactatgtc ggcttcccgc tgggctcgcg gctgaacagt gcgatcgagc gggtagcggc
864481 caagcgtaag caggcggccg agaacggctc gctgcccgac acgaaagcca acgtcgccga
864541 agttcttgct aaggaatctg gtaaatcgag ctagtctgac gtgtcgtgcg cgtcctggta
864601 atcggttcgg gtgcccgcga acatgcgcta ttgctggcgc tcggcaaaga cccgcaggtt
864661 tcggggctaa tcgttgctcc cggcaatgca ggcaccgctc ggatcgccga gcagcacgac
864721 gtcgacatca cctccgccga ggcggtggtc gccctggctc gcgaagtcgg cgctgacatg
864781 gtggtgattg gccccgaggt accgttagtg ctcggggtgg ccgacgccgt gcgcgcggcc
864841 ggcatcgtgt gtttcgggcc cggtaaggac gcggctcgca tcgaaggctc caaagcattc
864901 gccaaggacg tcatggcggc ggccggtgtg cgcaccgcga acagcgaaat cgtagacagc
864961 ccagcgcact tggacgcggc cctggaccgg ttcgggccgc ctgccggtga cccggcctgg
865021 gtggtcaaag acgaccggct agccgccggc aagggtgtgg tggtgacagc ggaccgcgat
865081 gtcgcgcgcg cacacggagc tgccctgctc gaggccgggc acccggtgtt gctggagtcc
865141 tacctggacg gcccggaggt atcgctgttc tgtgtcgtcg accgcaccgt cgtggtgccg
865201 ctgctgccgg cacaggactt caagcgagtc ggtgaggacg acaccggact taacaccggc
865261 ggtatgggcg cctacgcgcc gctgccgtgg ttgcccgaca acatctatcg ggaggtggtc
865321 agccggatcg tcgaacccgt tgcggccgaa ctagtccggc gtggaagctc gttttgcgga
865381 ttgctgtatg ttggtctcgc gattaccgcc cgcgggccgg cggtggtcga gttcaactgc
865441 cgattcggcg atccggagac ccaagccgtg ctggccttgc tggagtctcc gctcggccaa
865501 ctgcttcatg ccgccgctac cgggaagctg gccgatttcg gcgagttgcg gtggcgtgac
865561 ggtgtggccg taacagtggt actggcggcc gaaaactatc ccgggcgccc ccgggtcggc
865621 gacgtcgttg tcggctccga agccgagggg gtgctgcacg ccggaaccac gcggcgcgac
865681 gatggcgcga tcgtttcgtc cggtggccgg gtgctgtcgg tggtgggcac cggtgccgac
865741 ttgtccgcag cacgcgcaca cgcgtatgaa atcctcagtt caattcggtt gccaggaggt
865801 catttccgca gcgatatcgg tttacgggcg gccgagggga agatcagcgt ctagcaggct
865861 gcggcttggc catcacggcg gggatcgctg gccgcgaggt acccatcgtc gagccgccag
865921 attgcctgac aactcccgaa ctggctgtag tccgctactg cgaccaagtc atgcccacgc
865981 tgccgcagtt catcgagagt tgaatccggg aagccgtttt cgaaactgac ccgcataccg
866041 ttcacccagc ggaaccgagg gccgtcacag gccgcctggg ggttctggcc gtagtcggcg
866101 atgcgcacca gcacctgcac gtgaccctgg ggttgcatca tgccgcccat caccccgaag
866161 ctcatcaccg gcgcaccgtc gcgggtcaca aaacctggga tgatcgtgtg ataggggcgc
866221 ttccgtggcc caacccggtt cggatgtctc ggcaccacag tgaaatccga gccgcgattg
866281 tgcagcgaaa tgccggtgcc gggcaccacc acaccggagc cgaacccaag gtagttcgac
866341 tgaatcatgg acaccatcat tcccgcagca tcggcggcgg ccagatagac ggtgccgcct
866401 cgcgggatgc cggtggccgc cggcattgcc ctctttggat cgatcagcgt ggcgcgctgc
866461 cgcagatact ccttgtcgag caggcgcttc gggtgcaccg gcatgtagtc gatgtcggcg
866521 acacacgctt gcgcgtcggc gaaggcaagc ttcagtgctt cgatctgcac gtgcacactt
866581 tcagcggaat ccactgacca cgatgacata tcgaaatgct cgaggattcc gagggcgatc
866641 aaggccacga tgccctggcc gttgggcggt atctggtgga tggtgtaccc gcggtaggtt
866701 cccgtgatcg tgtcgaccca gtccacgcga tgggcggcga ggtcgtcggc acgcatcacc
866761 ccgccgtttg ccgccgagtg cgcctcgagt ttggcggcca gctctccccg gtagaactcc
866821 tcaccgttgg tcgccgcgat cttctctagc gtcgccgcgt ggtcaggaaa ggtaaacagc
866881 tcaccgggtt tcggcgctcg tccgccgggc atgaacgcat cggcgaatcc gggctgggat
866941 gcgaacaacg gcacctgtgc cgcccattgt gccgcgacgg tcggtgagac cagaaagccg
867001 ttgcggccgt acgagatggc gggctcgaag agtgtttcga atggtagcct gccgaacctg
867061 gcgtgcagtt ccacccaggc cgacaccgca ccgggcaccg tcacggagtt ccagccgagc
867121 acgggaacgg cgttgccgcc gaagtactct ggcgtccacg ccgagggtga gcggccggac
867181 gcgttcaggc cgtgcagttt ttgcccgtcc cagacgatgc tgaaggcgtc cgagccgatg
867241 ccattggaca ccggttccac cacggtgagg gtgatggctg tggcgacggc ggcgtcgacc
867301 gcgttgccgc cgtcggccag catccgaaga cccgcttgcg cggccagcgg ttgtgacgtg
867361 cacacgacgt ttgtcgccag gatgggcatg cgcggccaag cgtaggggaa ggtccaacca
867421 aacggcgtgc tcacgccgct taacctgtga gcagcggcgc gaaccaggtc agctcggcgg
867481 gtagctgtgc gctccagaac ccaccgttgt gcccgccagg ggagaagccg cccgccggcg
867541 ggtggggcag ctgcgccacg aactgcttgg ttgcggcata aaacggatcg ctgttgccgc
867601 aatcgacccg gatcgggatg gaccccaatg cggggagtcc gaaaaccgag ttcgccgacc
867661 agtcgtcggg tccgtcgaag gagccgggtg cgacggaacc ggcggatagc cacagtgccg
867721 ggctgaccgc gcagatcgct gcggtgcgtg ccggtccaag gcggctgccg agcagcaaag
867781 cgccgtagcc gcccatcgac cagcccagaa acgctacccg ggaggtgtcc agccgctggg
867841 tgtccaatag cggaatgagc tcgttgagca ccattgcccc cgcgtcctcg ccagaagccc
867901 gctggtgcca gtagctgctg cctccgtcca cggagaccac cgcgaacggt ggcaacccgg
867961 cgttgacggc ctgggccagg ccctgctcga cgccgccgtc catcacggcc gatgcgctac
868021 cgcccaagcc gtgcagtgcg atcacgggcc gcaacgcctg ggtctggccg ggtgggcggg
868081 cgatggccca gttggtcatc ttcccggcgc gcgctgccga cacgaacgag ccggtggaca
868141 tcgtcggcgc cgcctgagcc gggggggccg gatcgagtgc tggtgtcggc gccaatggaa
868201 cgtttgtgcc aatcgccgcc gccggtgcgg catgtgaagt tcggggctgc aacagcatgt
868261 cgatcgcata tgctgaggta gcgccaagga ccgtgccggc gccgagaccg agcacggcgc
868321 ggcggctcaa ctctggcatg cgggccatca tgccatggac gtttggccga attggcaatg
868381 cagtaccact ttgactggca gcatggatgg gcgtgacagc agcggtcact ccaaaaggag
868441 aacgtcggcg gtatgcgttg gtcagcgccg ccgcggagct gctcggcgag ggcgggttcg
868501 aggcggtacg ccaccgggcg gtggcgcggc gggccggttt gccgttggcg tctaccacct
868561 actacttctc gtcgctcgac gatttgatcg ctcgcgcggt cgaacacatc ggaatgatcg
868621 aggtggctca gctgcgagcc cgggtcagtg cgctgtcccg gcgacgtcgg gggcccgaga
868681 ccaccgccgt tgtgctggtt gacctgctgg tgggggaaat gtccagtccg gggcttgccg
868741 agcagctgat ctcacgatac gagcgccata tcgcctgtac ccgcctgcct gacctgcgcg
868801 aaagcatgcg ccgcagcctg cgtcagcgcg ctgaggccgt ggccgaggcc atcgagcgct
868861 ccggccgctc cgcacagatc gaactggtgt gtacgttgat ctgtgcggtc gacggatcgg
868921 tggtctcggc gctggtcgaa gggcgggacc cgcgtgccgc tgcgctggcg acggtggtcg
868981 acctcatcga cgtgctcgcg cccgtcgacc agcgtccggt gccgttctga agtcggtggg
869041 cagcgacggc gtgacaatgt acccggtggt gaagtcccca tagatcgtga catcggcggg
869101 ccggcgttgg gcgtacaacg ccacgtaggc gcatacgacg gcgtcgatcg gatcctcggc
869161 ggcccgcagg tcgctttttc gctgcgcgac cgtcacctgc cggcgcaacg agacccaatc
869221 cggctgaccg gctacctgca tccgaacccc ggcctgggcg agcccctcga cgccgtccat
869281 cagtcgcaat agctccgatt tgagcaggtc aacgctgcgt cccggcttgg ccttgtactt
869341 cagcgcgcgg ggtagccgaa acagcgccac cgtagccggg tgcggataga cctcgatggc
869401 ccgccgcgtg gcggacgaaa gaggatccat atccagcgcc agttggcggg ccagccgggc
869461 ggcgcgtgga acgtcggcaa actcgggctt ttcggtgttg gccggatacg cgccggcctc
869521 gaattgtcgg aagtctcgat tcagtgcggc ctccgccggc cgctggccgg tgcggttggc
869581 caccaccagc ggcgcgtcga aggcgaccag gcaatcgccc acaacgtagg gccgcagcgc
869641 cgccagcacg gaggcatcgt cgcgagcggc accgaccccc accagacacc cgtccgcgtc
869701 gacagccgcg acaccggtcg gattgcggcc ggcccaggcg aggtccacgc cgacgaagta
869761 catctgccca gggtatggcg gggccgcggc gtatgtgctg tggtgtcaca tccgtcactt
869821 gcgcctctgt cagagggatg cgcgttgtgc ccgtctcata gcgacatcgc ccgggcggca
869881 ccgggaccgg gcgttgccga gttgtcgcga tgagtcgggc acatcgggtg ctccctggcg
869941 ccgggactcg tgtgacaact gcgactacta ggcccgcgac cgtaagctgt gtctttgtga
870001 gggccaagtg agcattccca acgtgctggc cacccgatac gccagcgccg agatggtcgc
870061 gatctggtcg ccggaggcca aggtggtctc ggagcggcgg ttatggctgg ccgtattgcg
870121 ggcacaggca gagctggggg tagcggttgc cgattcggtg ctcgccgact acgaacgtgt
870181 ggtcgacgat gtggacttgg cctcgatctc agcccgggag cgggtgctgc gccacgatgt
870241 caaggcccgc atcgaggaat tcaacgcatt ggccggtcat gagcacgtgc acaaggggat
870301 gaccagccgc gacctgaccg agaacgtgga gcaactgcag attcggcggt cgctggaagt
870361 gattttcgcc catggggtgg cggcggtggc gcggctggcc gagcgggcgg tgagctaccg
870421 tgacctgatc atggccgggc gcagccacaa cgtggccgct caggccacca ccttgggcaa
870481 gcggttcgcc tcggcggccc aagagatgat gatcgcgttg aggcggttga gggagttgat
870541 cgaccgctac cccctgcgtg gcatcaaggg cccgatgggc accggtcagg acatgctcga
870601 tctgctgggc ggtgaccgtg cggcgctggc cgatctcgag cggcgcgtcg ccgacttctt
870661 gggctttgca actgttttca acagcgtggg gcaggtgtat ccgcgttcat tggaccacga
870721 cgtggtttcg gctctggtgc agctcggcgc ggggccgtca tcactggcac acacgattcg
870781 attgatggcc ggccacgagc tcgccaccga gggtttcgcg ccgggtcagg tcggttcgtc
870841 ggcgatgccg cacaagatga acacccgcag ctgcgaacgg gtcaacgggc tgcaggttgt
870901 gctacgcggc tatgcatcca tggtggccga gttagccggt gcacagtgga acgagggtga
870961 tgtgttttgc tccgtggtgc gccgggttgc gttgccggac agcttctttg ccgtcgacgg
871021 gcagatcgag acgtttttga cggtgctgga cgagttcggc gcctacccgg cggtgatcgg
871081 ccgcgagttg gatcgttatc tgccgttcct ggccaccact aaggtgctaa tggcggccgt
871141 gcgcgcgggg atgggtcgcg agtccgcgca ccggttgatc tccgagcacg cggtggcgac
871201 ggcgctggcc atgcgagaac acggcgcgga gcccgacctg ctggaccggt tggccgccga
871261 tccgcggctg acgctgggac gagacgcttt ggaggccgcg ctggccgaca agaaggcatt
871321 tgccggtgcc gcgggtgacc aggtcgatga tgtggtcgcg atggtggacg cgctggtgag
871381 ccgttacccg gacgcggcta aatacacgcc gggtgcaatt ctttagtgtc atgactaccg
871441 ccgccgggct ttcgggcatc gatctgaccg atctggacaa cttcgccgac ggcttccccc
871501 atcacctctt cgccatccac cgtcgtgaag cgccggtgta ttggcatcgg ccgaccgagc
871561 acaccccgga cggggagggc ttctggtcgg tggctaccta cgccgaaacc cttgaggtgt
871621 tacgtgatcc ggtgacctat tcgtcggtca ccgggggcca acgtcggttt gggggcacgg
871681 tgctgcagga tctgccggtc gccggccagg tgctcaacat gatggatgat ccccggcaca
871741 cccgtatccg gcggttggtc agctcgggct tgacaccacg gatgatccgg cgggtcgaag
871801 acgatctgcg ccgccgggcg cgtggattgc tcgatggcgt agaacccgga gcgcctttcg
871861 acttcgtggt cgagatcgct gccgaattgc ccatgcagat gatctgcatt ctgctgggtg
871921 tgccggagac ggatcgacat tggttgttcg aggcggttga gccgggattc gatttccgcg
871981 gctcccgcag ggcgacgatg ccgaggctga acgtcgagga tgccggatcg cggttataca
872041 cctacgcatt ggagctgatc gccggtaaac gcgccgaacc tgccgacgac atgctgtccg
872101 tcgtcgccaa cgctaccatc gacgatccgg acgcgccggc gctgtccgac gccgaactgt
872161 acctgttctt ccatctactg ttcagcgccg gcgcggaaac cacccgtaac tccattgccg
872221 gcgggctgct ggcgctggcc gagaaccctg accaactgca aacgctgcga agcgattttg
872281 agttgttgcc gactgcgatc gaagagatcg tgaggtggac gtcgccgtca ccatcgaagc
872341 ggcgcacggc gtcccgtgcg gtcagcctgg gcggccagcc gatcgaggcg ggtcagaagg
872401 ttgtggtgtg ggagggctcg gccaaccgtg atcccagcgt gttcgaccgc gcggacgagt
872461 tcgatatcac ccgaaaaccc aatccgcacc tgggtttcgg tcagggggtg cactattgcc
872521 tgggcgccaa tctggctcgg ctggaactgc gggtgctgtt cgaggaactc ttgtcccgct
872581 ttggctcagt gcgggtggtg gaacccgcgg aatggacacg tagcaaccgg cataccggca
872641 tccggcacct agtcgttgaa ttgcgcggag gctagtcccc gcgcagcggg attccggcgg
872701 cccgcaactc gagcgcggcc agcgcacgca tggtggcggg atcctctcgt cgccaggcgc
872761 cgaccggatc ggtgctgacg gcggccagtt tgcccggcgg ccggttcgcc aatgcgcgca
872821 gcgccagcag ctggcgaccg gctggggtcg ccgccagggt ggtaacggtc cacttgcgcc
872881 ggcagaaccg cagccgcagg aacagccagg gcatggccac ggcaagaatc ggcgtcgcgg
872941 cgaccgccag cgcgagcact accgcaagcc agccggccgt ggtgtccagg ttgtggccgg
873001 cgccggcgat gtcaagggcg gcctggcttg cggcggtgat ggggttgctg agcgcgtcgc
873061 ccaccaccgg gatacgctgg gcgtcctggc ccgcggccgc caggttgccg gcaatcccgt
873121 gcgagccgat ttcgatttgg cggccggcct cgccgattat cgagatggcg tcgtgcacgg
873181 cgaggccgac gagcatccat agcgtcgtcc acaccgcgac agtgatatcg ctgatcagtt
873241 gggccagcag tcggccgggc gtggtggcat acggcaagaa gcgcgatctc ataccagaga
873301 taccagcaca gggcgccgtc gtgcggcgga taggctggcg cgatgcgccc cgcattgtcc
873361 gactaccagc atgtggccag cggtaaggtc cgcgagatct accgtgtcga tgacgagcac
873421 ctgctgctgg ttgccagcga ccggatctcg gcgtacgact acgtcctgga cagcaccatc
873481 ccggacaagg gccgcgtcct gaccgccatg agcgcattct tcttcgggct cgtcgatgcc
873541 cctaaccatc tggccgggcc gccggacgac ccgcgtatcc ccgacgaggt gctgggccgc
873601 gcgctggtgg tgcgtcggct ggagatgctg ccggtggaat gtgtggcccg tggctacctg
873661 accggttcgg ggttactgga ttaccaggca accgggaagg tatgcggtat cgcgctgccg
873721 ccgggcctgg tcgaggccag tcggttcgcc acaccgctgt tcaccccggc gactaaagcc
873781 gcgttggggg accacgacga gaacatctcg tttgaccggg tggtggagat ggtaggcgcg
873841 ttgcgtgcca accagctgcg tgatcgtact ctgcagacgt atgtgcaggc cgccgatcac
873901 gctctcaccc gcggaatcat tatcgccgac accaagtttg aatttggcat cgaccgccac
873961 ggcaacctgc tgctggccga cgaaatcttc acaccggact cgtcgcggta ctggcctgcc
874021 gacgactacc gggccggcgt ggtccagacc agcttcgaca aacagtttgt ccgcagctgg
874081 ctcaccggct ccgagtccgg ctgggataga ggcagcgatc ggccgccgcc tccgctcccc
874141 gagcatatcg tcgaggccac gcgtgcccgt tatattaatg catacgaacg gatttccgaa
874201 ctaaaattcg acgactggat cggccctggc gcatgatgca ccgaaccgca ctaccctcac
874261 cgcccgtggc caagcgggtg cagacccgcc gggagcacca cggcgacgtc tttgtcgacc
874321 catatgaatg gttgcgcgac aaggacagcc ctgaagtaat cgcctacctc gaagctgaaa
874381 acgactacac cgaacggacc accgcgcacc ttgagccatt gcggcaaaag atcttccacg
874441 aaatcaaagc gcgtaccaag gaaaccgact tatcggtgcc gacgcgacgt ggcaactggt
874501 ggtactacgc gcggaccttt gagggaaagc agtatggcgt acactgtcgt tgcccggtaa
874561 ccgatcccga cgactggaac ccaccagagt tcgacgagcg caccgaaata cccggtgaac
874621 agcttctgct cgacgagaac gtggaagctg acggccacga cttcttcgca ctgggcgcgg
874681 ccagcgtcag cctggacgat aacctcttag cgtattccgt tgatgtcgta ggtgacgaac
874741 gatatacctt gcggttcaag gatttacgca ccggagaaca gtacccggac gagatcgccg
874801 ggatcggagc gggagtcacc tgggcagctg acaaccactg tctactacac caccgtggac
874861 gcggcctggc gtccggacac agtgtggcga taccgactag ggtccggcga atcgtcggag
874921 cgggtttacc acgaagccga tgatcggttc tggctcgcgg tggggcgtac tcgcagcaac
874981 gcctatctgc tgattgcggc ggggtcgtcc atcacttcgg aggtccgtta cgcgcacgcg
875041 gcagatccga cagcgcagtt cagcgtggtg ctgccgcgcc gcgacggcgt cgagtactcg
875101 gtggagcatg cggtcatagc tggccaggac cggtttctga tcctgcacaa cgacggcgcg
875161 gtgaacttca cactggtaga ggccccggtc gaggatcctg cgcggcaacg caccctcatc
875221 gcccaccgcg acgacgtccg actcgacgcg gtggatgcct tggccggcca tctggtagtc
875281 agctatcggc gcgaggcgct gccgcgggtt caactgtggc cgatcgggcc tgacggaaac
875341 tatggtgagc ccgaagagat ctcgttcgac tccgagctga tgtcggccgg actggggccc
875401 aaccccaact gggattcgcc caaactgcgg gtcggtgccg gatctttcgt caccccggtg
875461 cggatctacg acatcgacct ggtcactggc gagcgtacct tgctgaaaga acagcccgta
875521 ctgggcggct accgccgcga agactatgtg gagcggcgtg actgggcgta cggagacgac
875581 ggcacccgga tcccggtctc gatagtgcac cgagccgata tcgaattccc ggcacctgcg
875641 ttgatctatg gctacggcgc ctacgagatc tgtgaggatc cgcggttttc catcgctcgg
875701 ttgtcgctgc tggatcgcgg gatggtgttc gtcgtcgccc acgttcgcgg cggcggtgag
875761 atgggcaggc tgtggtatga aaacggcaag ctactggaca agaagaacac gttcaccgac
875821 ttcatcgcgg tggcaagaca tctggtggac acgggactta cttcccagca gcagctggtg
875881 gcattggggg gtagcgcggg cggtctgctg atgggcgcgg tggccaacat ggcaccggat
875941 ctcttcgccg gaatccttgc gcaggtgccg ttcgtggacc cgctgaccac catcttggat
876001 ccatcgttgc cgctgaccgt caccgagtgg gacgaatggg gaaatccgtt gaacgacagc
876061 gatgtctatg cctatgtgaa atcgtattcg ccgtacgaga acgtcacggc ccaaaagtac
876121 ccggccatcc tggcaatgac gtcgctgaac gacaccaggg tctattacgt ggagccggcc
876181 aagtgggtgg ccgcgttgcg gcacgccaag accgacggca attccgtgct gttgaagacc
876241 cagatgcacg ccggtcatgg tgggatcagt ggccgctacg agcgctggaa ggagaccgcg
876301 tttcaatacg ggtggttgct agctactgcc gacagcgacc gttacggcgg cggccaggga
876361 aacgacctcg atggcgctgc gccagcatag ccggtgggat cggccattcg ggatgcgtag
876421 acattggctc cgaacatggc cagcatcagc gccagcgagc ataccgccgc tgccatgcgg
876481 gtgtcgggca gcaacaggcc cacggcgacc aggagcctcc agcgcaccgg tgatggtgac
876541 cagcaggccg ggcgcaagca gcccgggtga aacgatggcg atgaggtggc cgcgcagggg
876601 cggcgtgaag tgagctcggc tgctcgacgg ctccgattcc gaactggtcg acgccgagac
876661 cgccgctgcc gccgagctgg cgcgcggggt ggcggcgctg cgcgatccca acgcccgggc
876721 gaatccggcg ggtgccgagc tggcgacctg gtcgctggtg cacggctttt cgacgctgtg
876781 gctcgacgat gcggtcaacg ctgacgtgaa gcagacgtca tgcggatagc aacggtgctc
876841 ttcgatgact agcctgctgt ttcggcagga atgccgcggg gatcagcgtc gagaccacta
876901 gcgcggtcgc tatcacgaat accaccgcgt aggcgtgcga aaggtcatgc agcagttggg
876961 ccgcgaagtt ggtttggcgc ggtagcgagg aagggtcaac cgccgccccc cgcccggcgc
877021 cactctctgg ggtcagtgcg actttctttg cagtagcgat gatttcgctg tgattgaact
877081 ggtaggtgag cagcaccgac atcagtgcgg tccctatcga accgcccacc tgctggttga
877141 cgctgatcag cgtcgaaccg cgagcgatct gatgtggggc cagggtctgc actgccgccc
877201 cggacagtgg catcatggag cagcccatgc ccatgcccat gattgccagc ccggtcggca
877261 gaatgggtaa gtagtccgct tgccgcgcga caccaaaggc gaaggtgccc aaccccgcag
877321 cgatcagcat gatcccaacc agcacgatct tggccggtcc ccgtcggtcc atcatcgctc
877381 cggcgatcgg catcgccagc atggcaccga ggccctgtgg gatgatatgc acccccgatt
877441 gcatcggtga ttggtgcaac acttgctgga ggtagctcgg gagcagcaag aaggagccaa
877501 acagcccgag ggagagcacc gtcatcgtca tgttggcctg cgcgaccgct cggttctgga
877561 acaagcgcat gtctatgagc ggatgttctg tgcggtacca cgaatgtgcg acgaatgccg
877621 cgatcaacgc caggccggtg atcgccggta tcaacacgtg ccgatcggcc atcgttccac
877681 gggcggggct agatgacacc ccgaacagga aggtcgccag gcccggcgac agcaacaaga
877741 ggcccatgta gtcgaagttt tccgacgctg ccgggcgatc tcttgggaac acgatcgccg
877801 ccaagacgag cgcggacagc ccgaccggca ggttgaccaa gaaaatccaa cgccagccgt
877861 aggccccgat gagccaacca cccaggatcg gcccaccgac cgggccgagc agcatcggaa
877921 tgcccaccac cgccatcacg cgccccagcc gcttcgggcc cgcctcacgg gccaagatgg
877981 caaaggacac cggcgtcagc atgcccccac cgaaaccctg gacaacacga aatatgatga
878041 gcagcaagat gtttggtgct actgcgcaca gcagtgagcc gagggtgaac gccaataccg
878101 aacccatgaa aagccgcctg gtgccgaacc ggtcggccgc ccaaccggct gtcgggatca
878161 cagtggccaa cgcgagcatg tagccggtca tggtccaggc cacgacggcc tgggtggacc
878221 cgaaatcggc aacgaaggtg cgttgcgcga cgctgaccac ggtgacgtcc acatgtgcca
878281 tcaccgaggc caggacacac actccggcgg tccgaagcaa ccccacatcg agcctatcgg
878341 gatagctgcg ttggccagag cggggccgcc ccgcgggggt gatgggcacc ggggcatcgc
878401 cttccgcggg acacgcttca accatggcgt tgccgagcat atcgataccg gtcacgggta
878461 ccgcgcgagg atgtcgggcg gtgcttggtt ccggcgtcgg gtcatggccc tggcgccgag
878521 ccgacgtgcg ctcgttctgc gctggtcagg gtccagatat acgcctgctg tccgcgtgtc
878581 cttcaccgtc cggaaacctg gaatcggcag actgcaagcg tgtctggaaa actgctcgtg
878641 tcggtctcgg ggataggtga gagcaccctg gccgatgtcg acgcgttctg cgcggaaatg
878701 gacgcccgct cggtgccggt atcgttgctg gtggctccgc gtatgcgcga tgactaccgg
878761 ctcgaccgcg acccacgcac cgtcgactgg ctgaccggtc gccgggccgc cggcgacgct
878821 ctggtactgc atggctacga cgaagcggcc accaagaggc ggcgcggcga attcgcaatg
878881 ctgcgcgcac acgaggccaa cctgcggctg atggccgccg accgggtgct cgaacacctt
878941 gggctgcgaa cccgactgtt tgcggcaccg ggctggctgg tatcaccagg tgtccgtaca
879001 gcgttgccgg ccaatggatt tcggctgctt gcggatctcc atggaatcac ggatctggtt
879061 cggctcacca ccgtgcgtgc ccgcgtgctg ggcatcggcg agggtttcct ggcggagccc
879121 tggtggtgcc ggatggtggt gatgtcggcc gagcggatcg cccggcgtgg gggcgtcgtc
879181 cggattgcgg tggccgcccg tcatttgcgc aagtccggtc cgctgcaggc gatgctcgat
879241 gccgtcgacc tggcgatgct gcaggggtgc acaccgatgg tgtaccggtg gcgagccgat
879301 gcggcggtac tcgacgcggc ctgaccgagc gcctgatcgg tggcgttaac ctgtaccgac
879361 atgagcgatg ctgtagccgg ttcagatgcc gaggggctca ccgctgatgc cattgtcgtg
879421 ggagccggat tagcgggcct ggtagccgct tgtgagttgg ccgaccgcgg cctacgggtg
879481 ctgatcctcg accaggagaa tcgggccaac gtgggcgggc aggccttctg gtcgttcggc
879541 ggtttgttct tggtcaacag tcccgagcag cgccgcttgg gcatccgtga tagccatgag
879601 cttgctctgc aggattggct ggggacggcg gcgttcgacc ggcccgagga ctactggccc
879661 gaacaatggg cgcatgctta cgtcgatttc gcggcggggg agaagcgcag ctggctgcgg
879721 gcccgcgggc tgaagatctt tccgctggtg ggctgggccg agcgtggtgg ttacgacgcg
879781 caggggcacg gcaactcggt gccccgtttc cacatcacct ggggtactgg gccggctctg
879841 gtcgacatat tcgtgcgtca gctgcgtgat cgccccacgg tgcgctttgc gcaccgccac
879901 caggtcgaca aactgatcgt cgagggtaac gcggtgacag gcgttcgggg taccgtgctg
879961 gagccctcgg atgagccgcg cggcgcgcct tcgtcgcgaa agtctgtggg gaaattcgag
880021 tttcgcgcgt cagcggtgat cgtcgccagt ggtggtatcg gtggcaatca tgagctggtg
880081 cgcaaaaact ggccgagacg gatgggccgc attcccaagc aactgttgag cggggtgccc
880141 gcgcacgttg atggcaggat gatcggcatc gctcaaaagg ccggggctgc ggtgatcaat
880201 ccggaccgga tgtggcatta caccgaaggc attaccaact acgacccgat ctggccgcgg
880261 cacggtatcc ggattattcc ggggccgtcg tcgctatggc tggatgccgc gggcaagcgg
880321 ttgccggtac cgttgtttcc cgggttcgac accctcggca cattggagta catcaccaag
880381 tctggacatg actacacctg gttcgtgttg aatgccaaga taatcgagaa ggaattcgcg
880441 ctgtccggtc aggagcagaa ccctgacttg accggtcggc gcctgggcca gctgttgcgc
880501 tctcgggctc acgccggccc gcccggaccg gtgcaggcat tcatcgatcg tggtgtggac
880561 tgcgtccacg cgaactcgtt gcgcgagttg gtggccgcga tgaacgagtt gcccgatgtg
880621 gtgccgctgg actacgagac ggtggcagcc gcggtcactg cgcgcgatcg tgaggtggtc
880681 aataagtaca gcaaggatgg acagatcacc gcgattcgtg ccgctcgccg ctaccgaggc
880741 gaccgatttg gccgggtggt ggcgccacat cggttgaccg atccgaaggc cgggccgctg
880801 atcgcggtca agctgcacat cctgactcga aagacgttgg gtggcatcga aactgactta
880861 gatgctcggg tgctcaaggc cgacggtacg ccactggccg ggttgtatgc agccggcgag
880921 gtcgccgggt tcggcggggg cggtgtccat ggctaccggg ccttggaggg caccttcctg
880981 ggtggatgca tattttccgg ccgcgctgcc ggccgcgggg ccgccgagga tatccgctag
881041 ttgtggccgc ttgacatagg agctattgct cgcgctagaa ggtgaccgcg ctttcctcgg
881101 gcaacacctg aaagtcggtg gtggtcatct cggtgagccg gccgtagtag atacccctgg
881161 cgtccggagc gacgatggct tggtggatgg gtaccgctcg tgccggagct acggcccgca
881221 ggtagtcgac cgcctcggag atcttcatcc atggggccgc ggcgggagtg gccagtacgt
881281 ccacctgctc gccgggaacg aacaacgcgt caccgggatg catcagtctt gcccgatgtt
881341 tactgtcgcc caccagatac gaaatgttct ctatcacagg gatttccggg tggatcaccg
881401 cgtggcaacc gccgaccgca cggacggtca gctccgctaa cggcagctcg tcgccaacgt
881461 gcaccgcccg ccatggctcg cccagctgcg ccgccgtctg cggatcggcg tacagctcgg
881521 cagccgggtt gtcctcgagc agggtcggca gccgcgtgac gtctatgtga tcggggtgct
881581 ggtgggtgat caagatcgcg gacaaaccgg tgattccctc gaagccgtgc gagaaagtac
881641 cgggatcgaa gagcaggcgg gtttgaccga actcagcgag gaggcaggaa tggccgaaat
881701 gcgtgagttg catgtttacg attgtgccct tatgggggcg tttccgatgc ggttgatcct
881761 ggcgacgatg ctggtcgccg gtcgcttgtt ggcgacgctc atggccgcgc ctagcgccca
881821 ggctgagccg gaaacctgcc cgccgatatg cgaccagatt cctgctaccg cgtggatcag
881881 cacccacgcc gtgccgttga actcgcaata ccgttggccg gcaatggccg gcgcggcagt
881941 ggcggtgacc agggcgacac cacgtttcgg gttcgagcag gtgtgcgcca cgccggcgtt
882001 cccgcacgac agccgcgatt gggcggtcgc gggccgggtc acggtggtcc accccgacgg
882061 ccagtggcag ttgcaggctc aggtgctgca ctggcgcggg gacaccgccc gcggtggcca
882121 gatcgcggcg tcggtgtttg gcaccgccgt cgccgcgtta cgcgcctgcc agctgggcgc
882181 accgctgcag tcgccgtcgg tcaccgacga cgaaccgacc cggatggccg cggtgatcag
882241 cgggccggtc atcatgtaca cctacctggt cgcgcacgta tcaagcagca cgatcagcga
882301 actcaccttg tggtcgtccg ggccgccaca agttccgtgg cctacggttg cggactccgc
882361 ggttctggac gccctgaccg cgccgttatg cgaagcctac atcggctcgt gcccgtgacc
882421 aggcggggca cctgccgccg gtagagttgg cgcgggaatc attgcccggc tcctggcggc
882481 cgctgtcgcc gggcgcggcg ggcagatctg aggaggagcg ccggtggcca gggtggtcgt
882541 gcatgtgatg cccaaggcgg agattcttga cccgcagggc caggcgattg tcggtgcgct
882601 ggggcggctt gggcatctcg gaatatcaga tgtgcgtcag ggcaagaggt ttgagctgga
882661 ggtcgacgat acggttgatg acaccacgct tgccgagatc gcagaatcac tgttggccaa
882721 caccgtgatc gaggactgga cgatcagccg ggacccgcag tgacggcgcg catcggtgtc
882781 gtcacgtttc ccggcacgct cgacgacgtc gacgccgcgc gcgcggcgcg gcaggtgggc
882841 gccgaggtgg tcagcctgtg gcatgccgac gccgacctta agggtgtcga cgccgtagtg
882901 gtgcccggcg gattttccta cggtgactac ctccgggccg gagcgatcgc cagattcgct
882961 ccggtgatgg acgaagtggt agctgccgcg gaccgcggca tgccggtgtt ggggatttgc
883021 aacggctttc aggtgctgtg tgaggccggg ctactacctg gtgccctgac ccgcaacgtg
883081 ggattgcact tcatctgccg ggatgtgtgg ctgcgggtag cgtcgacgtc gacggcgtgg
883141 acatcgcgtt tcgagcctga cgccgacctg ttggttccgc tgaagtccgg cgagggccgt
883201 tacgtggcgc cggagaaggt gcttgacgaa ctagaaggcg aaggccgggt ggtgttccgc
883261 taccatgaca acgtcaacgg ctcgctgcgc gacatcgccg gcatctgctc agccaacggc
883321 cgtgtcgtcg gcctgatgcc gcaccccgaa catgcgattg aagcgttgac cgggccgtcc
883381 gacgacggac tgggtctgtt ctattcagcg ctggatgccg ttctgacggg ctgaggtcac
883441 ccgctcacgc tcacccggcg tctcgcagca acggcggcgt cgcggttgga ggtaatccgg
883501 ctgccgtcag ctgaccgaag agctccgtcg cggccgagac ggcgttgtcg acgaaggtgg
883561 cgaaatcgtc gaaccggatg cggtccctga tcaaggaccg ctctgcggcc acgccgatgc
883621 ggtgcggatc agaggacccg tgcacgatcg cggtgacctc gtggttctgc aggttccacg
883681 cgttgacgat ctccgccaac cgggtgtggt cggtggcggg gaagaagtat gcgggactga
883741 ccctgatcgt gaacacgtcg cggtaggcgg gagagatttc taggtggacg tgcagccgca
883801 ggtgggcgtt ggcgacgaag aagaactcgg cgtcgtggtg gccacggaag tatcgccggc
883861 cgcgggcgcg caggtagcgc tcgatcaggt tggtgctcag cggctcgcct atcgactcag
883921 tcatgaactc atgatgcggc cggcgccttg gtgaatcctt tgagctggga acccggttgc
883981 gaagaacaag atgagaattc cctgagcgac gcggggcagc ccggccactg tgaatggcac
884041 gacgcgacac gcggcggagg cgtcgtgaga ttcacagtcg gtgggttgcg tcggccaatt
884101 caaccggggg gccggtccac agttcctcgt cagcggctac caaggcgtgt acttcggtgg
884161 actgcaacgc cttcaggacc gactgagcga ttcgttcgta ccattgcgcg accgcgctgg
884221 gatagtcggc gtagctgccg ttttcccgca ggatggttcc ttccaccgtc gggatcgggg
884281 tagctccgtc gaattcttgc cggtagggct tgccgaggcg ggcggcggtg ggtgcgtcga
884341 tggtggcgtc cagcttgacc catcgccgac caagatatgc ctcacccagc gagtgccacg
884401 ggaagggccg gccagttcgg cctccccata gggcacgtac ctgcggggac agaaactcct
884461 tatcgggggc gtcgatcgtc tggaacgcga tacgggccgg gacaccggcg gctcggcaca
884521 gggcgacgaa ggaacttgcc ttgcccatgc agaaggcgac cccgtggccg atcacgtcgc
884581 tggcgcggtg atgtccctgc gcgaggtagc gaaaggacgc gaggacgtcg tatggcacgt
884641 cgcgcacgta gtagtagatc cgcctgaccc gctcggtatc cgacaccgcg tcccggatga
884701 gggttgctgc cgtcgtacga acgagcggat ggcccgcgtc gaggtactcc gtgggcgtca
884761 gaaagtggtc catgccggtt ccattgttgg ctagcgtcat ggaatcgtga cctcagtttt
884821 gacccgcgga atgatgtcac tgccgatgat gtgcagataa tcggacttca cgacgtgtgg
884881 aatcgtgaag agaaaatggc cgacaccgcg gtcctggtat tcacgaatgc gctcgacaca
884941 cctgtcgggt gtcccgacga tgagccccgg ctcggggatg gacgcgaatt cttcgcggat
885001 ccggacttct tcctcgccgg actgggtggg tgccagcagc agcgtgaccg acagtcgcag
885061 cgtgtcgggg tcacgcccgg ccgcctccga cgcctgggtg agaaatccgc ggcgttgggt
885121 gacttgctgc ggcgaccacc agcgcacgtt caggccctgg gcatgcttag cggcgatgcg
885181 ctggacccgg tcgccttccc cgccgatcca caacggagga tgtggccgtt gcaccggcgg
885241 cggatcgcag gtggcgccgt ccaaggtgta aaaccggccg gcgtaggtgg ggtttggctc
885301 ggtccacacg gccttgatga cctgcagcga ctcggcaagc gcggagactc ggtcgccaac
885361 cggcgggaac gggatgccgt aggcttgcga ctcgcgccga aaccagccgg cgcccaatcc
885421 cagatcgaga cgtccctggg aaatgacgtc cagcgtcgca gccatcttgg ccagcacgga
885481 aggatgacgg taggaattgc acagcacgct ggtgcccaac cgcagcttcg tggtgtcgcg
885541 ggacaatgcc gcaagtgcgg tccagcactc gagcaggggc agcgacctcg aaggggcgca
885601 ctggcccgcc ccgccggttt cggtgccggt cgcggagccg gtgtcggcgg cgatgccggc
885661 gaccttcgca tactcgccgg ggcttatcgt caggaagtgg tcgcataacc acactgaatc
885721 gaatccgtat tcttccgccg tctgcgagac gacaaccatt tcgcggtaac tgccgaccgc
885781 caggccatta accgtcgcag ccaacatgag tccgaagtgc gggtcgtctt tggcgttcat
885841 gcgaaatctc gtttctcgat aattccggca cctgatccgg gcaacgttcg gggtaacgtg
885901 acggagaact ggtaccgctc ggggcgatgg tggaacacga ccacttcaag gggcttgccg
885961 tcattggtgt agctggtgcg gtcgacgacc agtaccggcg aacccaccgc cagacccaac
886021 gcgtcggcta cgtcggggga ggccccggcg gcatggattt cgtgggtagc ctgtgcaatg
886081 cgtacaccca gtcgccgctc ccacatcgca tatgtggttt cggtgtccgc gctgcccgat
886141 agcaacggct cgacggctgg gcccacgccg ggcggaagat aggccgtgac cagggccaag
886201 ggttgatcgc cagtgcggat gcgccggcga atacagagga cctcaaccaa acccagcgtc
886261 tcggaaatcc gttgcggcgc cggtccggtc tggtgtgaca gcacgtcgac ctgcggggta
886321 acaccacagc tcaacaacac ctctgtgatg gtgcgcacgc cgcaactgag ctcctgttcc
886381 accggatcgg cgacgaaggt acccaagcct tgccggcgca ctagccatcc ctgacgttgc
886441 agcatgccga ccgccgcgcg cacggtcacg cggctcaaac cggaacggtc gatcaattct
886501 cgttcgctgg gcaagcgccc gccgcgcggc agccgctgct ggatgatctg ggcctttagc
886561 gcctcggcaa gctgggtact cgccggcacg ctgccacgcg atatccgcag atcggcagcg
886621 tccaggtcca gcttgacaga tgtcataaga cgtattaaaa cgtcttatac tcaccacgtc
886681 aagcgtgcgt gcgcggtagc agcggaagaa ggtcagccat gacgtcaccc gtcgcggtca
886741 tcgcccggtt catgccacgg cctgacgcta ggtcggccct gcgcgctctc ttggacgcaa
886801 tgattacccc gacacgggcc gaggacggat gccgtagcta cgacctctac gagagcgccg
886861 acggcggcga gctggtgctt ttcgaacggt accgcagccg catcgcgctc gacgagcacc
886921 gcggttcgcc gcactatctg aactaccggg cacaggtcgg tgaattgctg acccggcccg
886981 tcgcggtgac tgtgctcgcg ccgctcgacg aggcttctgc ttagagcggg tagcacccag
887041 gcagcttgat ccacgcccgg caccggccga gcgctcggga accgccgcag accaccgcag
887101 tccccccgtg ggttcagcgg cgcggcggcg ggttggctat accagcaggt aaaacgaatc
887161 tcggtaggat tcaagaagtc tcagccacag ttcgctgatg gtcgggaagc acggaacggc
887221 gtgccacaac cgatcgattg gcacctggcc ggcgacggcg acggtggccg aatgcaacag
887281 ctcggcggcg cccgggccaa ccatggtcac gcccagcaga tggccccgat cgacgtcgac
887341 caccatgcgc gccctgccgg tgtatccgtc ggcaaagagc ttggctccca taacgacatc
887401 gccgatttcg acatcgatcg ctttgatccg gtgaccagcc tgtgcggcct gatcagctgt
887461 caggccgacc gctgcggctt cggggtcggt aaagaatgcc tgcggcaccg cgtgatggtc
887521 ggcggtggtc gcgtgcatgc cccacgacgt ggtgtctagc ggtcgtccgg cggcacgggc
887581 gccgatcgcg gtgccggcga tccgcgcctg gtatttgcct tggtgggtca gcaacgcgcg
887641 atggttgacg tcgccggcgg catagagcca gccgtcgtca acagcccgca ctcggcaggt
887701 gtcatcgacg tccagccagc tgcccggcgt cagtcctatt gtctccaagc cgatgtcgtc
887761 ggttcgcggt gctcggccgg tggcgaagag tacctcgtcg acccgcagct cggtaccgtc
887821 gtccagctcg aggaccactg ggccagttgg gttggggcgg cccagcgcgc gtaccgatac
887881 tcccacgcgc acgtcaacgc cggcgtcggc cagtccgcga ccgatgagtt cccccacaaa
887941 cggttccatt cggggcagca ggccagatcc ccgagccagc agggtcaccg aggcgcccag
888001 tccctgccag gcggtcgcca tctccacacc gacgccgccg gcgccgacga tcgcaagccg
888061 gtcggggacc gtactgttgt cggtggcttg gcgattggtc catggccggg cttcggtgat
888121 gccaggaagg tcggggagtg ctggccggct tccggtgcag atgacaacgg catgccgggc
888181 ggtcagcgcc acgctttcgc cgctcgactt ggtgacgacg acgcggcgcg gaccgtccaa
888241 tcgcccgtca ccgcgtatca gcgtcgcgcc gattccactc acccagtcgg cctggccggt
888301 gtcgtcccag tgggccacat agcggttgcg gcggccaaag acgccggctg tgttgatcga
888361 gccgtcgact gcttcgcgcg cgccgtcgac ccgtcgggcg tcagagatcg cgatgaccgg
888421 acgcagcaag gctttgctgg gcacacaggc ccaataggag cattcacccc cgacgagttc
888481 gcgctccacc accgcgacac gcaggccccc cgcgcgggca cgatcggcga cgttctgtcc
888541 aacgggtccc gcgccgagca cgacgacgtc atacgtttca ccctcacggc agccgggtgt
888601 tgccattggc gcctggtcct gttgggccgc ggtcataatc aaagatcctt tcgtcggact
888661 ctgccagcga cgctacgcgc gcctagcgcc ggtgagccgt gccggcctat cgcccaccag
888721 acgcaaaagc tctcgacacg ccgtgcgaaa agggaccttt atgtctcagt gtcggtgttg
888781 tgtgtgccgc gaggtgggtg tgtcggtgtg acagacgccg tgtcgcggtg gtttgttccg
888841 gatcacctgg tgtctggctc actttgcgtc tgccgtcctc ttggggttgg cgttgagcag
888901 tattgccggc actaggtgag aaggaccggc cggcgtgact tgataggagc gtggctttcg
888961 ccccgactga gatgtgtccg ccgaccggcc caacctcaac accccctcaa gtgaaggagg
889021 tgaaccgccc cggcatgtcc ggagactcca gttcttggaa aggatggggt catgtcaggt
889081 ggttcatcga ggaggtaccc gccggagctg cgtgagcggg cggtgcggat ggtcgcagag
889141 atccgcggtc agcacgattc ggagtgggca gcgatcagtg aggtcgcccg tctacttggt
889201 gttggctgcg cggagacggt gcgtaagtgg gtgcgccagg cgcaggtcga tgccggcgca
889261 cggcccggga ccacgaccga agaatccgct gagctgaagc gcttgcggcg ggacaacgcc
889321 gaattgcgaa gggcgaacgc gattttaaag accgcgtcgg ctttcttcgc ggccgagctc
889381 gaccggccag cacgctaatt acccggttca tcgccgatca tcagggccac cgcgagggcc
889441 ccgatggttt gcggtggggt gtcgagtcga tctgcacaca gctgaccgag ctgggtgtgc
889501 cgatcgcccc atcgacctac tacgaccaca tcaaccggga gcccagccgc cgcgagctgc
889561 gcgatggcga actcaaggag cacatcagcc gcgtccacgc cgccaactac ggtgtttacg
889621 gtgcccgcaa agtgtggcta accctgaacc gtgagggcat cgaggtggcc agatgcaccg
889681 tcgaacggct gatgaccaaa ctcggcctgt ccgggaccac ccgcggcaaa gcccgcagga
889741 ccacgatcgc tgatccggcc acagcccgtc ccgccgatct cgtccagcgc cgcttcggac
889801 caccagcacc taaccggctg tgggtagcag acctcaccta tgtgtcgacc tgggcagggt
889861 tcgcctacgt ggcctttgtc accgacgcct acgctcgcag gatcctgggc tggcgggtcg
889921 cttccacgat ggccacctcc atggtcctcg acgcgatcga gcaagccatc tggacccgcc
889981 aacaagaagg cgtactcgac ctgaaagacg ttatccacca tacggatagg ggatctcagt
890041 acacatcgat ccggttcagc gagcggctcg ccgaggcagg catccaaccg tcggtcggag
890101 cggtcggaag ctcctatgac aatgcactag ccgagacgat caacggccta tacaagaccg
890161 agctgatcaa acccggcaag ccctggcggt ccatcgagga tgtcgagttg gccaccgcgc
890221 gctgggtcga ctggttcaac catcgccgcc tctaccagta ctgcggcgac gtcccgccgg
890281 tcgaactcga ggctgcctac tacgctcaac gccagagacc agccgccggc tgaggtctca
890341 gatcagagag tctccggact caccggggcg gttcagaggc aaccaccatg gttgttgttg
890401 gaaccgatgc gcacaagtac agccacacct ttgtggccac cgacgaagtg ggtcgccaac
890461 tcggtgagaa gaccgtcaag gccaccacgg ccgggcacgc cacagccatc atgtgggccc
890521 gtgaacagtt cggcctcgag ctgatctggg gcatcgagga ctgccgcaac atgtcggcgc
890581 gtctggagcg tgacctactg gcggccggcc agcaggtggt gcgggtaccc accaagctga
890641 tggcccagac ccgcaagtcg gcgcgcagtc ggggcaagtc ggatccgatc gatgcgctgg
890701 cggtggcgcg ggcggtgatg cgtgaaaccg acctacccct ggccacccac gacgagacgt
890761 cgcgggagtt gaagttgttg actgaccgtc gagatgtcct tgtggcccaa cgcacgtcgg
890821 cgatcaaccg gttgcgctgg ctcgtccatg aactcgatcc cgagcgggca ccggcagcac
890881 gctcgctcga tgccgccaag caccagcagg ccctgcggac ctggctggac acccagccag
890941 gattggtcgc cgaactcgcg cgcgccgagc tgaccgacat catccggctc accggcgaga
891001 tcaacaccct agcccagcgc atcagcgccc gagtccacca ggtcgccccc gcactgctgg
891061 aaatccctgg ctgcgcggag ctgactgcag ccaaaatcgt cggcgaagcc gccggagtga
891121 cccggttcaa aagcgaagcc gccttcgcct gccatgccgc agtggctccc atcccggtgt
891181 ggtcgggcaa caccgccggc cagatgcggc tcagccgctc gggcaaccgc cagctcaacg
891241 ccgccctaca ccgcatcgca ctgacccaaa tccggatgac cgacagccgg ggccaggcct
891301 actaccaaag gctgcaagac gccgggaaaa ccaaacgcgc agcactacgc tgcctcaaac
891361 gccgcctagc ccgcaccgtc ttccaggccc tgcgcaccgt ccaccagccc agctccgaac
891421 acacccaacc cgcggccgct tgccatagga gctattgctc gcgctcgtgc cttagtggct
891481 gagcgcgacc gacgcctcgg cggtgtagca aaggaacgtc agcgtctcct gcaggtagag
891541 gcgcacggtg tccgtgtcgt ggctggcgta cccgattgca acgtcggtgc ccagctgtag
891601 gtcgaagtcg ccgcctcgag tggtcagcac gaacgcgccg tcgatggccg gggcccaaat
891661 gatgtccccg tccaccagcc ggttcagatg ctcacggatg ggatagccgt gatcggaagt
891721 ctcgctaacc ttggtgtaga cgtcagcaga gagcaacacc gaatacggtc cgtccacacc
891781 ggccaaccgc agttcggaca atgcctggga gatgacatca gggatttcac ggggatcctc
891841 gggcaacgtc agcgccgggt tcgaactcgc gctgcggatc ccttcgattg atgcggcgct
891901 gtagccttcg aatattgtgc ggtcctcgac gaaggccagc ttcttggccg cctcctttac
891961 cggttcccaa tcggagtcct tagagccacg ttccacgtcg tcgatctcgt tgcgcgacag
892021 ggtaaacgga acccgtagcc ggacaagggg tttgctggcc cgcaggtggg cgatcacgcc
892081 gttggttggt gccttaacat cgatcagccg gccggtgctg accgccgcgg tgacgggccc
892141 cccgggatca ctgacatcga ccacccggcg cccggcgatg tgtcgcttga acgtccgcgc
892201 cgcctccaat tcgatttccg cccaagcggc ttcggtgacc ggtgccaaat cgcggtagag
892261 attgttcatc gggggcttcc tttcaagctg ccgatcgata gcgacccggc tgccagagtt
892321 ggcgtcgccg cctgcggtag gggcggtgga tggtcgagaa agtcgatggt gggtgagaag
892381 aacagtccgc cggtcaccgc ggtggaaaag tcaagcactc gatcggtgtt gcctgccgga
892441 tcgccgagaa acatgttgcg cagcatctgc tcggtcaccg ttggcgtgcg cgaatatccg
892501 atgaagtaag tgccgtactc gcccttgccg acttcgccga acggcatgtt gtgtcgcacg
892561 atcttgcgct cggtgccgtc gtcgtcggtg atgacgttga gcgctacgtg tgaattggct
892621 ggcttcgcgt tgtcgtcgag ttcgatgtcg tcgagcttgg tccggccgat cacacgctcc
892681 tgctcggtga ccgagaggga ttcccacgag gccatatcgt gcacatactt ctgcacgtgc
892741 acataacacg agccggcgaa atttcgatcc tcgtcaccga tcgtggtggc cttgatggcg
892801 attgggccac ttgggttttc ggtgccatcg acaaagccca gcagatcacg gttgtcgaaa
892861 aaccggaagc cgtgcacttc gtcgacaacg gtcaccgcat cgcccatcga cttgagaatg
892921 cggccagcca actcgaagca cacgtccatg gtctcggccc ggatgtggaa caacagatcg
892981 ccgggagttg ccggggcggt atgccgtggt ccggtcagct cgacgaacgg atgcagctcg
893041 gtgggtcgag gtccggcgaa caagcggtcc caggcgtcgg acccgatcga gacgaccacg
893101 gacaagtgtt tggtcgggtc acggaagccg atcgcacgca ccaggccgga gatcttcgac
893161 agtgcgtcgt gcaccgtcgc ctcgccgtcg gcgccgatgg tggcgaccag gaagatcgcg
893221 gccggagtca acggcgccag aatcggctgc ggagagacag caggcacagc cacgacccta
893281 acgtccctgc aataccggtg atgctagaca tggctacatg gcggccacgg cacacggcct
893341 gtgcgaattc atcgacgcgt ccccgtcgcc gtttcacgtc tgcgcgacgg tggcgggacg
893401 gctgctcggc gccggatacc gcgagctgcg cgaagcggat cgctggccgg acaaaccggg
893461 ccggtacttc accgtccggg ctggctcgct ggtggcgtgg aacgccgagc agagcgggca
893521 cacgcaggtc ccattccgga tcgtcggcgc gcacaccgac agccccaatc tgcgggtcaa
893581 gcagcatccg gacaggctcg tcgccggctg gcacgtggtg gcgctgcaac cgtatggggg
893641 agtttggctg cactcctggc tggatcgcga tctgggcatc agcgggcggc tatcggtgcg
893701 tgacggtacc ggggtcagcc accggctggt cctgatcgac gacccgatcc tgcgggtgcc
893761 gcagctggcg attcacctgg ccgaggaccg caagtcgctc acgctcgatc cgcaacgaca
893821 catcaacgct gtatggggcg tgggagagcg ggtggagtcc tttgtggggt acgtcgctca
893881 gcgcgccggg gtggcggcgg ccgacgtgct ggccgcggac ctgatgaccc atgacttgac
893941 cccgtcggcg ctgatcggcg cttcggtcaa cggcactgcc agcctgctca gcgcgccgcg
894001 gctggacaac caggccagtt gctatgccgg gatggaggca ctgctggccg tggacgtgga
894061 ctcggcgtcg agcggattcg tgcccgtgct ggcgattttc gaccacgagg aggtgggatc
894121 ggcctcgggc cacggcgcac agtccgatct gctatccagc gtgctcgaac gcatcgtgct
894181 cgcggcgggc ggcacccggg aggacttcct gcgccgactg accacctcga tgctcgcctc
894241 ggccgacatg gcgcatgcga cgcaccccaa ctacccggac cgtcacgagc cgagccaccc
894301 gatcgaagtc aacgcgggtc cggtgctcaa ggtgcaccca aatctgcgct acgccaccga
894361 cggacgcacc gcggcggcgt tcgcactggc ctgccagcgc gcgggagtgc ctatgcagcg
894421 ttacgaacat cgcgccgatc tgccgtgcgg gtcgacgatc gggccgttgg ccgcggcgcg
894481 caccggaatc cccacggtcg acgtcggcgc cgcccagctg gcgatgcact ccgcgcgaga
894541 gttgatgggc gctcacgacg tagccgccta ttcggcggca ctgcaagcgt ttctttccgc
894601 cgagctatcc gaggcatagg gtcgggcggt atggcactca aggtagagat ggtcactttc
894661 gactgcagcg accctgcgaa gcttgccggc tggtgggccg agcagttcga tggcacgacg
894721 cgtgaactgc tgcccggcga attcgtcgtg gtcgcccgga ccgatggacc gcggttggga
894781 ttccagaagg tgcccgatcc cgcccctggg aaaaaccgcg tgcacctcga cttcacgacc
894841 aaggacctgg atgccgaggt gttgcgcctg gtcgccgccg gagccagtga ggtcgggcgg
894901 catcaggtcg gcgagagctt tcgctgggtg gtgctggctg accccgaagg caacgctttt
894961 tgcgtggcgg gtcaataacg aggcggttcc aaggggccga aaagcggccg gcagcggtcg
895021 aacccgtcca cccgaacctc aacagtgcga tggcgctgcc aatcgtcgcg ggtcagccgg
895081 aataacagcg cctctgccat agccccttcg cgtgccacgc gatctaggcc gttgtcgcgg
895141 tatccgttac ggcgggatac cgcgatcgag gccgggttat ccacgaacga cctcgacgtc
895201 gcgacctgcg cctccagctc ggcaaacgcg aaatacagta cagccgcccg catctcggtg
895261 ccgtagccgt gaccttggta acgcaacccg agccatgatc cagaatccac ctgacgggtg
895321 attgggaaat ccttggagct cagggcctgt acgcctacgg ccctaccgtc gacgaggacg
895381 gccagcggca gcgaccagtc atcccgcttg aacccggcca gttgctgcca taggtgcgac
895441 agcgtgttga acggcaggtc ctcgcgcgat gctcgcgtcc acggaaccga aaacggcatt
895501 cggtcggggt cgtggactcc ctccaggatg gtgtcgatca gctggtcgca caactcctcg
895561 gtgggcagtt gcaactggag ccgcggcgtg gtgatgcgca ggtcgaacaa cggccagtga
895621 cgagacatgg ttccattttg cgcaccacca tcctgagcgc ccgccccgat gtcagcccga
895681 cggctgatgc caccggggtt cttgccgcgg gcatacctat ccgtcggctt gtccgtgtca
895741 acgcggccgc agcgcgatgg ggcctagcta gactgcctcc gtgatgtctc cgctcgcccg
895801 gaccccgcgc aaaacgtcgg tgctggacac cgtcgaacac gccgcgacca cacccgacca
895861 accacaaccg tatggtgagc tgggcctcaa agacgacgag taccggcgga ttcgccagat
895921 cctgggccgc cggcccaccg acaccgagct ggccatgtac tcggtgatgt ggagcgaaca
895981 ctgttcgtac aagtcctcca aggtgcacct gcgctacttc ggtgagacca cctccgacga
896041 gatgcgcgcg gccatgctgg ccggcatcgg cgagaacgcc ggcgtcgtcg acatcggcga
896101 cggctgggcg gtcaccttca aggtggagtc acacaaccac ccgtcctacg tcgagcccta
896161 ccagggcgcg gccaccgggg tgggcggcat cgtccgcgac atcatggcca tgggcgcccg
896221 accggtcgcc gtgatggacc agcttcggtt cggcgccgcc gacgcccccg atacccgccg
896281 cgtgctcgac ggcgtggtcc gcggcatcgg cggatacggc aactccctgg gcctgcccaa
896341 cattggcgga gagaccgtct tcgacccgtg ctacgccggc aaccccttag tgaacgcgtt
896401 gtgtgtcggc gtattacggc aggaggacct gcatttggcg ttcgcctccg gcgccggcaa
896461 caagatcatc ctgtttggcg cgcgcaccgg gctcgacggt atcggcgggg tgtcggtgct
896521 ggcgtcggac accttcgatg ccgagggatc ccgcaagaag ctgccctcgg tgcaggtcgg
896581 cgacccgttc atggagaagg tgctcatcga atgctgtctc gagctctacg cgggcggcct
896641 ggtgatcggc atccaagacc tgggcggagc cggattatct tgtgccacat cggagttagc
896701 atccgccggt gatggcggaa tgacgatcca gctggacagc gtcccgctgc gggccaagga
896761 gatgacgccc gccgaggtgc tctgcagcga atcgcaggag cggatgtgcg cggtggtctc
896821 cccgaagaac gtcgacgcat tcctggcggt gtgccgcaag tgggaggtgc tggcgacggt
896881 gatcggcgag gtcaccgacg gcgaccggct gcagatcacc tggcacggcg agacggtggt
896941 cgacgtgccg ccgcgcaccg tagctcacga aggtccggta tatcagcgcc cggtcgcccg
897001 ccccgatacg caggacgcgc tgaacgccga ccgctcggcc aagctgtcac ggccggtcac
897061 cggcgacgag ctgcgcgcga ctttgcttgc gttacttggc agcccgcacc tgtgcagccg
897121 cgcgttcatc accgagcagt acgaccgcta tgtgcgcggc aacacggtgc tcgccgagca
897181 cgccgacggc ggcatgctgc gcatcgacga gtcgaccggc cggggcatcg cggtatcgac
897241 cgacgcgtcg ggacgctaca cgctgctgga tccctacgct ggcgcgcaac tcgcgttggc
897301 cgaggcgtac cgcaacgtcg ccgtcaccgg cgccaccccg gtcgcggtga ccaactgcct
897361 gaacttcggt tcccccgagg accccggcgt gatgtggcag ttcacgcagg cggtccgcgg
897421 tctggccgat ggctgtgcgg acctcgggat tccggtgacc ggtggcaacg tgagtttcta
897481 caaccaaacc ggttcggcgg caatcctgcc cacgccggtg gtcggggtgc tcggcgtcat
897541 cgacgatgtg cgtcggcgca tccctaccgg cctgggcgcc gagcccgggg aaacgttgat
897601 gctgttgggc gacacccgcg acgagttcga cggttccgtg tgggcgcagg tgaccgcaga
897661 ccacctgggt ggattgccgc cggtagtcga tctggcgcgg gagaagctgc tggccgcggt
897721 gctgagctcg gcgtcgcggg acgggctagt gtccgcggcg cacgatctgt ccgagggtgg
897781 gctggcccaa gccatcgtgg aatcggcgtt agcgggtgaa accggttgcc gcatagtgct
897841 tcccgaaggg gctgacccgt ttgtgctgct gttctccgag tcggcgggtc gggtgctggt
897901 cgcggtgcca cgcaccgagg agagccggtt tcgcgggatg tgtgaggcgc ggggacttcc
897961 cgcggtccgc atcggcgtcg tcgatcaagg ttcggacgcg gttgaggtgc agggcttgtt
898021 cgcggtgtcg ttggccgaac tgcgtgcgac atccgaggcg gtgttgccgc gatacttcgg
898081 atgagtcggc ttcgcgccct gtctttggcc gccggcctgg tcggctggag tctggtcagc
898141 ccgcggctgc cggcgccgtg gcggattccg ttgcaggcgg ggctggggag cgtgttggtg
898201 ctggttactc gtgcgacgat gggcctttgg ccgccgcggc tgtgggccgg gctgcggctg
898261 ggctgggccg cgggggcggc ggcggcgacc gcgatcgcgg caacgacgcc ggtgccgatg
898321 gtgcggttgt cgatgtcggc tcgtgagttg ccggcgtcgg tgccggtctg gctggtatgg
898381 cacatacctg gcggcacggt gtgggccgag gaggccgcgt ttcgcggggc gctggccact
898441 atcggtgccc gggccttcgg tcggtcgggt ggacggatac tgcaggccgg cgcctttggt
898501 ttgtctcaca tcgccgacgc gcgcgcgacg ggcgagccgc tggtgctcac ggtgttggcc
898561 accggtatcg ccggctggat gttcggttgg ctggccgacc ggtccggcag tctggcagca
898621 ccgctgctga cgcacttggc catcaacgag gccggtgcgg tcgccgcggt gctggtccag
898681 cggcgttctg gtatctcgac tcgactgtga tcgcggggtc gggcccctgg tgatcgtgga
898741 acggctcaca acagcgcgga cctggtcggc ggcgccgcta tactgattgg tcactgtcta
898801 accaatcaat ggagagggtt ggcacctcag gtgcatagac ttagggccgc ggagcatccg
898861 cggccggatt acgttctctt acatatcagc gacactcatc tcatcggggg ggatcgtcgg
898921 ctctacgggg cggtggacgc cgacgaccgg ctgggcgaac tgctcgaaca gttgaaccaa
898981 tccggccttc gtcccgatgc gatcgtcttc accggcgatt tggccgataa gggcgaaccg
899041 gcggcatacc gcaagctccg aggcctggtc gagccgttcg cggcgcagtt gggcgccgag
899101 ctcgtctggg tgatgggtaa ccacgacgac cgggccgaac tacgcaaatt cttgctggac
899161 gaagcgccat cgatggcgcc gctagaccgg gtgtgcatga tcgacggtct gcgcatcatc
899221 gtgttggata cctcggtacc cggacatcat cacggcgaaa tccgcgcgtc ccaattgggt
899281 tggcttgctg aagagttggc cacgccagcg ccggacggca ccattttggc gttgcatcat
899341 ccgccgattc cgagtgtttt ggatatggcc gtcacggtgg agctgcgcga ccaggctgcg
899401 cttgggcgag tgctgcgggg cactgacgtt cgcgccattt tggccgggca cctgcactac
899461 tcgacgaatg ccaccttcgt cgggatccca gtgtcggttg cctcggcgac ttgctacacc
899521 caggacctga ccgtcgctgc tggaggaacg cgtggcagag acggcgccca aggttgcaac
899581 ctggtgcacg tctatccgga caccgtcgtg cattcggtga ttccgctggg cggcggagaa
899641 acggtcggca cctttgtctc acccgggcag gcgcgacgca aaatcgccga gagcggcatt
899701 ttcatcgaac cgtcgcgtcg cgattcgcta ttcaagcacc ctccgatggt gctgacgtcc
899761 tcggcaccgc gaagtcccgt cgactgacgt ccgcggcgat cttctcccag ggagccggta
899821 tcgggaaata gcgctccagg aaactgacga ctcgttctgc gcgctgcgct gcggggactt
899881 caggaaagct accgtcgttg aggcagaaga aatcgtatcc gcggtgcttc cgcaacttag
899941 gaagtagccg aagacccgca tagctggtgg tgtcgacata gaggacttta gccttttcct
900001 gcgggacggc gcgtccggtc atcagcgcgt aatagtggta gaacgagttg gtcaccgaga
900061 tgtcggtgtc ggagcggaac gggctggccg cggtgcgggc gaattcctcc gggaattccc
900121 gctccatctc gatcagcaca ctcttgcgca acggtaccgc ggtgtgctcg agatgacggg
900181 taatcacctg cccgaaccgg tcgaagagca gctgccggtt tacccgggcc gcgttttcaa
900241 agccactacg cgctgggttg ttggcgccga gcccgatccg ggtcttggct tcgatgaacc
900301 tggtgactcc accgggagag aagaacatac tggccttgag cggccggccg aagaacatgt
900361 cgtcgttgga gtacaagaag tgctcgctga gccccgggat gtggtgcagc tggctctcca
900421 ccgcatgcga gttataggtc ggcaacgcgg aacggtcgga aaagtggtcc tcggcgcgaa
900481 cgatggtgat tttaggatgt tcggccaacc atggcggcgg ggttgaatcc gtcgcgatga
900541 agatgcgacg tatccacgga gcaaacatgt tcaccgaccg cagcgcgtat ttcaactcgt
900601 cgatttggcg gatccgcgct tcggcgtcgt cgccctcgcc caccacgtac tgcgacattt
900661 gagccatgcg gcgcgcccgg aactcggggt cactaccgtc cacccaggag aacaccatgt
900721 ctatgtcgaa cacgacgtcg ctggcgtgcg gggcaaacat cccgtcaagg gtcggccatt
900781 tgtacccgta gagtttgaca tttgtcggcg ttatttcgtt tcggggcagc actttgcggc
900841 taagcgagtt ttcgacaggg cagcggatca ccgtctcctc gtatacccag aattgcagtt
900901 ccacaccgaa cgccgggccg tagcgaaatc cgcccggcgc gatccggcgt cgatacaacc
900961 gcacgacacg cgggtcaacc agctgcgaca gcccgtcggt ggcgaccaaa acaggagaaa
901021 ggccaggctc atcaatagtt ttggcgtaca tcggttcggt tgcacatgcg gccgcaagag
901081 cgcgctcgag gccggcacgt agttcgatgt tgatggcaag caccggccgg ttcttgtggt
901141 ttcggatcag tagataggga atatcagccc tgtttaacac ctttcgcaga aagaccagat
901201 cttcgatctg ggcctcctgg ggggtcaggc cggattccag gcgggcgatc ttgccgcgcc
901261 gggtaacgat gatgggattc acggtgcgct gagcgggccg accgccgtcg cgcgaagaga
901321 ttttgggcat cgggtcaccg ccttgggaac tcagggagaa atgattaggt caccgaaaga
901381 atctcacaga tcgcgggtcg gcgcaggttg accgcgctgg cgcggggtcc atacagaatt
901441 gtgcggtcaa ggcgataact cttgcaagac accagatcta gcgatctaag aacatcggcc
901501 ggaaacctgg ttgttgcggc cgcgccatgt caagttcagt tcggaactgg gctcgcatac
901561 aacccgatcc cagtctcagc agcggcgctt ggccgccatc tggatggatc caccgattct
901621 tgagacccta aggtatgagc gctcgtgatc gagtcgatcc ggcgaagact cggcaggtcg
901681 tgttggccct cgcggactgg ttgcgcgacg aaacgttgcc agcacccgac accgacgtgt
901741 tggcggcggc ggttcggctt acggcgcgca cgctcgctgc gctggcccct ggcgccagcg
901801 tcgaagtccg gatcccaccg tttgctgcgg tgcagtgcat ttctgggccc cggcacactc
901861 gcggcacacc ccccaacgtc gtgcagaccg acccacggac ctggctcctg gtggctaccg
901921 ggctgtcggg ggtggcgcag gcccggggca gtggcgcgct gcagctctcc ggctcgcggg
901981 ccggtgagat cgaggcctgg ttgccactgg tggatctcgg ctgattccgg cgtgctgagc
902041 tgcggctatg gtgtgtgagg gtggcgccgg ggtgcccgac acgtaagccg aattcggcgg
902101 tgcagacgtc gtggccgtag actcggatta cgtcaccgac cgcgccgcag ggagccgcca
902161 aaccgtgacc ggccagcaac ccgagcaaga cctgaactcg ccccgggaag agtgcggtgt
902221 cttcggggtc tgggccccgg gtgaagacgt cgccaaactc acctactacg gcctgtacgc
902281 gttgcagcat cgcggccagg aagccgccgg gatcgccgtc gccgacggct cccaggtgct
902341 ggtcttcaaa gacctcggcc tggtcagcca ggtgttcgac gagcagacgt tggcggccat
902401 gcagggccat gtcgccatcg ggcactgtcg ttactccacc accggggaca cgacgtggga
902461 gaacgcccag cccgtgttcc gcaacaccgc cgctggcacc ggtgttgcgt tgggccacaa
902521 cggaaatctg gtcaatgccg ctgcccttgc cgcccgcgcc cgcgacgcgg ggttgatcgc
902581 cacccgctgc ccagccccgg cgacgacgga ctccgacatt ctgggggcgc tgctggccca
902641 cggtgctgcc gattccaccc tcgaacaggc ggcgctggac ctgctgccca cagtgcgggg
902701 agcgttctgt ctgacgttca tggacgaaaa cacgctttat gcgtgccgcg acccgtacgg
902761 ggtgcgcccg ctatcgctcg ggcgtttgga ccgtggctgg gtggtggcct ccgaaacggc
902821 cgcactcgac atcgtcggcg cctcgttcgt ccgtgatatc gaaccgggcg aattgctggc
902881 tatcgacgcc gacggggtgc ggtccacccg ctttgccaac cccacgccca agggctgcgt
902941 attcgaatac gtctacctgg cgcggccgga cagtacgatc gccggccggt cggtacacgc
903001 cgcgcgggtg gagatcggtc gccgactggc tcgggaatgc ccggtcgagg ccgacttggt
903061 gattggtgtg ccggaatccg gcacacccgc cgcggtcggc tacgcgcagg agtccggcgt
903121 tccatatggg cagggtctga tgaagaacgc ctatgtcggg cgcaccttca tccagccgtc
903181 acagaccatc cgtcagctcg gcatccggct gaagctcaac ccgctcaaag aggtgatccg
903241 cggcaagcgg ctcatcgtcg tcgacgactc gatcgtgcgg ggcaacaccc agcgtgcgct
903301 ggtacgcatg ctgcgcgagg ccggtgcggt cgaattgcat gtgcgcatcg cctcgccacc
903361 ggtgaagtgg ccgtgcttct acggtatcga cttcccctcg ccggccgagt tgatcgccaa
903421 cgccgtggaa aacgaggacg agatgctgga ggcggtacgg catgccatcg gggccgacac
903481 gctgggatac atctcgctgc ggggcatggt cgcggcgtcc gagcagccca cgtcgcggct
903541 gtgcaccgct tgcttcgacg gcaagtatcc aatagagctg ccccgcgaga ccgcgctagg
903601 caaaaatgtc atcgagcaca tgctcgccaa tgcggcccgc ggagccgcgc tgggcgaact
903661 cgccgccgac gacgaagtcc ccgttgggcg ctgacaaaac gcacgcgcgg tagcctttat
903721 cgcgatgacg gatctcgcaa aaggccccgg aaaagacccg ggtagtcggg gtatcaccta
903781 cgcgtcggcc ggggtcgaca tcgaagccgg tgaccgcgcc atcgacctgt tcaagccgct
903841 cgcttcgaag gccaccagac ccgaagtgcg cggcgggctg gggggattcg ccggactgtt
903901 cactctccgc ggtgactacc gcgaaccggt gctggcggcc tccagcgacg gcgtcggcac
903961 caaactcgcg atcgctcagg cgatggataa gcacgacacg gtgggcctgg acctggtggc
904021 gatggtggtc gatgacttgg tggtttgcgg cgccgagccg ctgttcctgt tggattacat
904081 cgccgtcggt cggatcgtgc cggagcgact cagcgcgatc gtcgccggta tcgccgatgg
904141 gtgcatgcgt gccggctgtg cgctgcttgg cggcgagacc gcagaacatc cgggcctgat
904201 cgagcccgat cactacgata tctctgccac cggcgtcggc gtcgtcgagg cggacaatgt
904261 gctgggtccc gaccgggtca aacccggcga cgtcatcatc gcgatgggct cgtcgggtct
904321 gcattccaat gggtactcgc tggtccgcaa ggtgttgctg gagatcgacc ggatgaatct
904381 ggccggtcat gtggaggagt tcggtcgcac cttgggcgaa gagttattgg agccgactcg
904441 catctacgcc aaagactgtt tggccttggc cgccgaaacc cgtgtccgga cgttttgcca
904501 cgtcaccggc ggcgggctcg ccggcaacct gcaacgggtc atcccgcatg gcctcatcgc
904561 cgaggtcgac cgcggcacct ggacacccgc gccggtattc accatgattg cccagcgcgg
904621 ccgggtcagg cgcacagaga tggagaagac gttcaacatg ggtgtcggca tgatcgccgt
904681 cgttgccccc gaagacacga cgcgcgccct ggccgtcctg accgcgcggc acctggactg
904741 ctgggtattg ggaaccgtct gcaaaggcgg aaaacaaggc ccgcgggcaa aactggttgg
904801 gcagcacccg agattctaag aaccagacct aaccgggtct aatgaggtca acgccacgcc
904861 gatgggaacc gaatcggcac cgtgcggggg gcagctccgt ggtgctagcg ccgccagtcg
904921 tcctcatcgt tccacgagtc gtcgtccgac gggccgtcgc cgtccagtcg gtcggtaccg
904981 gtacctgaca gctcacgctg aagccgctgg aagtcggtct gcggggagct gtatttcaat
905041 tctcgagcaa ccttggtctg ctttgcctta gcccggccgc ggcccatggg ggaaccccct
905101 cgcgaaataa cggagcggcc taacgagtag gcggctccga tctctggtgt cgtttattgt
905161 cctgccgaca gtttaccgtg ccgcccggtc gggcgcgggg cggcctgccc gccgttacgg
905221 agggcacggg taatcaccga ataccgccgc gcagccgctc gacggcccgc cgtccggcgc
905281 ccacatcgtc ggcgggcggc agcgagtcga cgtcgatcac cgcggcaacc tcggcttccg
905341 gaccggttac cagggcggtg tcgcccggca gaccccgttt gagcagggcc agtgccaccg
905401 gccctagctc tacgtgctcg accaccgttc ccagtcgtcc caccgtgcga ccgccggcca
905461 gcaccgcatc gcccgtcgac ggccgctgca ctgactcgtc cagatgcaac aacaccagca
905521 tccggggtgg tctacccagg ttgtgcaccc gtgcgacggt ctcttgccct cggtaacagc
905581 ccttgttcag gtggacggct ccggcgccgg ggccaccgat ccaacccact tcgtgaggga
905641 tggtgcgttc atcggtgtca acgcccagcc gcgggcgcct agccggcacc cggtgagcca
905701 ctcgatgggc ttcataggcc cagatgccgg ccgggcgcac acccgcctga gtcaggcgac
905761 gctgccagtc ggcacgatcg ccgcgcttca ccaccacgtc cagttcgatt tggcccgcta
905821 ggccgtcggg catccggcgg acaatcccgc cgccggcaag cggcacggcc agccactcag
905881 cgggcaagac atctagaccc agcgcgtcga gcactcgttc ctcagccagc cgcggcccca
905941 atagcgacaa caccgccata tcagcggcac gaggagtgac catcgaccaa aaaaccatct
906001 tgcgcaaata ggccagcagc ggttcacccc gccacggctc ggtatcgaga taggtcgtgc
906061 cacccagctc ggtctgtatc cagtgatcct caactcggcc ttgtccgtcc aggctgagat
906121 tttgggtgct ggcgccctca ggcaggtcgc tgacgtgttg tgtggagatg ctgtgcagcc
906181 aggtttgccg atcgccaccg tcgagggtga gcacggcgcg gtgcgagcga tccaccagca
906241 cggcatcggc ttgccccgcg cgttgctcgc ccagcgggtc gccgtaatgc cagatcgcac
906301 ccgcgtcggg tccggggtct ggggcaggga ctgcggccac acaacaactc tacgaaaagc
906361 cgcgctcggc ctcgttgacc agcgtgcagc taggctgcag ggacatgttg aggcagacgg
906421 gcgtggtggt cacgcttgac ggtgagatcc tgcagccggg tatgccgctg ctgcacgccg
906481 atgatcttgc cgctgtgcgg ggggatggcg ttttcgagac actgctggtg cgcgacggcc
906541 gagcctgtct ggttgaagcg cacctgcagc ggctgaccca atcagccagg ttgatggacc
906601 ttcccgaacc ggatctcccc aggtggcgcc gcgcggtcga ggtggcaacg cagcggtggg
906661 tggctagcac cgctgacgag ggcgcgctgc gcttgatcta cagtcgcggt cgggagggcg
906721 gctcggcgcc gacggcctat gtcatggtca gtccggtccc ggcgcgagtt atcggggccc
906781 gccgcgatgg tgtgtcggcg atcacgctgg accgcggttt gccggctgac ggtggcgacg
906841 ccatgccgtg gctgatagcc agcgccaaaa cactgtccta tgcggtgaac atggccgtcc
906901 tgcgtcatgc cgcccggcag ggcgccggcg acgtcatctt cgtcagcacg gacggctacg
906961 tcctggaagg ccctcgctcg acggtggtga tcgccaccga cggtgaccaa gggggcggga
907021 acccctgctt gctgacgccg cctccgtggt atccaatcct gcggggaacc acgcaacaag
907081 cgctcttcga agtggcccgc gcgaaaggct acgactgcga ctaccgtgcc ctacgcgtcg
907141 ccgatctctt cgattcccaa ggtatttggt tggtatcgag catgactctg gccgcccgcg
907201 tacacaccct ggacgggcgg cgattacccc gcaccccgat cgctgaggtg tttgccgaat
907261 tggtggacgc cgctattgtc agcgaccggt gatacggcaa cctctgttgt ggtcagcgcc
907321 ggccataccg ctcgccgtta tccgacgaac cgggacaacc gcgccgacag atgtggtacc
907381 agcccgccgt cggcatcgac gcgttcctcg acgtaggcca ggtcgccacc ttcgacgatg
907441 ccgtagagtc gtttggcgcc gccgaccaga acgccagacc gactgcgggc cagcgcatcg
907501 gtcaccaact cccacgagga ctgggtgcgc ggccgcccgt agaacagttc gacataaccg
907561 gccgaatgcg ccaatagcaa ctcgatcgcc tgagactcgc tcggatcgta cgggtcggcg
907621 acgaaccgcc agaatcccgc ttctcgtaag cctggttcct ggtagtcgcc cgtggcggtg
907681 agccgccagg accgggattc ccaattcaga tagtcgccgc cgtcgtgtga cacaacgatc
907741 tgctggccga accggtagtc gccgtcgggt ccgcggccct cgccttcgcc gcgccacacg
907801 ccgaccagtg gcagcagcgc cagcagtgca ttgttcaggt cggcaccttc gcgcaggttt
907861 gcggtatctg cgggaaccgg caaatcgtcg aaggcaggga tattgcgcgc ggcggtcgcc
907921 ttggcccgct cgacggcagc ggcgaccgca cggtcgccgg agcccgcagc atggacgccg
907981 ccggccccgg tcgcatccga gcccgcgccg gaactcacga ctcgtcggta acgagccggt
908041 acagcgtgta cagcgcgaac caggagataa ccacggtcgc caagaccagc atgatctcga
908101 agaacagcac cacggggacg agtgtatgcg gccgcggccg cttccgtggc cctggctcgt
908161 ctgggcctga ttggggccgg tcaggtgatc ttgacgtcta cctcgtggat gcccgcgccc
908221 gagggctgca ccaccgcgtc gccgttgccg gccgccgaca gcgcgcgcag cgtccaggat
908281 ccgggcgcgg cgaagaaccg gaaatcgccg gtggccgacg cgacgacctc cgcggtgaac
908341 tcgtcggagg agtccagcag ccgcacgaac gcgccgccca cggcctggcc gtcaccgtcc
908401 actacgcggc cggtgatcac cgtttctttt tccaggtcga cgctggccgg caatgtcagt
908461 ccttgcttgg gtccagagca catatcagct tcccaactcg atcggggcgc ccaccaggga
908521 gccgtattct gtccaactgc cgtcgtagtt cttgacgttt tggtgtccga gtaattcccg
908581 caacacgaac caggtgtgcg aggaccgttc cccgattcgg cagtaggcaa tcgtttcctt
908641 gctgttgtct aggccggcgt cggcgtaaag cttggccaac tcctcatcgg acttgaaggt
908701 gccgtcctcg ttggcggccc tgctccacgg cacgttgatg gcaccaggaa tgtgtccggg
908761 ccgctggctt tgttcctgcg gcaggtgcgc gggggccagg atcttgccgg agaactcgtc
908821 gggagagcgc acgtcgatga ggttcttgac gttgatggcc gccaggacct cgtcgcggaa
908881 tgcccgaatc gtgttatccg gcggggaggc ggtgtaggag gtcaccggcc ggctgaccgg
908941 gtcgctggac agcgggcgtc cgtcgagctc ccacttcttg cggccgccgt cgagcaactt
909001 gaccttctca tggccgtaga gcttgaaata ccagtacgcg taggcggcga accaattgtt
909061 gttgccgccg tacaggatca ccgtgtcctc gttggcgatg ccacgctcgg acagcagctt
909121 ggagaattgc tgggcgtcga cgaagtcacg tttgaccgga tcctgcaggt cggtgcgcca
909181 gtccaacttg atcgcgccgg caatatggtc acggtcatat gcactggtgt cctcgtccac
909241 ttcgacgaaa acgaccttcg gcgcgtgcag attgctctca gcccagtcgg cggagaccag
909301 gacatcgcag cgtgccatgg cgggaatcct ttcgcatagt tcggtgacca gcgtggtcaa
909361 ctggttaggc gggacgggga gtgttactgc ttgactgctc cttgggacgt ctgttgcaca
909421 gaaacggcgg gcgacacgct acggtggggc tcctaggctg ctctaagtgc tgcgcggacg
909481 tgcgcggcta ctcagcagct acagcaacag caacaacccg ctaggcggca cagatcaact
909541 gcgcgacgct tggtgagcat gggctcgatg cgggctgaca cgtcggacag cttacccaat
909601 cgcatagtgc tcaagccaac agtggtttca gggcagagcg caggtcggcg gccttgggga
909661 ccccggaggt ccggtagcgc tgtcgcccgt cgacatcgaa gatcaacgtg gtgggcagcg
909721 aaagcaccga aaatcgccgc gctgcctgcg ggttggagtc caggtcgacc tcgatgtgag
909781 caacatctcc cagatcggcg cagacgtcgc cgacccctcg gcgtacccgg tcgcagggcg
909841 cacaccctgg ggccctgaaa tgcacgacgg tcggcccggc cccggacagg cccagttccg
909901 cggtgcgcgc cggagccgcc ggtgtcgttt ccggaccaac ctcccgcagg atcactgacc
909961 gccgggtcag caaccaccgg gcaatggtcg ccagcgcacc tgtagcaacg gaagcgacga
910021 tcatggtcgt catgactgtt tgaactcgtc gagcgagatc gttactcccc gggtaatgcc
910081 ttcgatgatg acgtccgatc cgcgcgcccc cacggtgttt ggcaccaccc cgaacggcag
910141 cttctggttg ggcagcttgc tggcgaaggc gtgcagcacc gcatcccgct tgtcatccgg
910201 aaccggttgg tccgcggtgt cgggtccggt cacgacggcg gtgggggtga taaccaaggt
910261 cgcgcggtcg tccgaggcaa cggacaggtc caccaagacg ctgacccggt gagcgaagtt
910321 ggccgatatg ggcgtgccgc tgaacaccag cccgcggctg ccagatatcc cggactcggt
910381 agtgccgccg gtggcgtcgt tgctctcctg acggggcgcg gcgaccataa ggtcgctaat
910441 gcccaggtag cggcccaggt gcatggagtc gatgatgatg cgactctcca gctcgccgac
910501 cgggagcttg gcatcgggcc tgatcagcca ggacgcgtag gacaagtcga tcgaatgcat
910561 agtggcctcc agagtggccg tgccacttcc ggcgtgctcc acggcaaatg ccttgatttc
910621 tagctccgcg tagtgttccc gcatcgcctg cgggatgaat gggaaccgca ggatggcgac
910681 gaacgggtct gacctcaggt ttgccgcttt gcgcacagtg gtcgacagcc ggtactcggc
910741 atagatgctg gccccgaaat cggcgccgac ggcgcccacg atgagaacgg ccacgacgat
910801 cgccgccccg gtcaccccga ccagcacctt gcgcatcggc atattgtcgc ccagcgctcg
910861 agcccgtccc ggagcgcctc gtcaggcggc acgttatcgt tagatgagct gccgctaccg
910921 tcacatggcg cgatgaactg ggagacgcct ttcccacgac gctggagggg cttgttggag
910981 ttattactgc tgacctcgga gctgtatccg gatccggtcc tgccggcgct gtcgctgctg
911041 ccccacaccg tgcggacggc gccggccgag gcgtcttcgt tgctggaggc gggaaacgca
911101 gacgctgtgc tcgtcgacgc gcgcaacgac ctgtcgtccg ggcgaggcct gtgccgcctg
911161 ttgagctcga ccggccggtc gatcccggta ctggcggtgg tgagcgaagg cgggctggtg
911221 gcggtcagcg ctgactgggg gctggacgag atcctgctgc tcagcaccgg gcccgctgag
911281 atcgacgcca gactgcggct ggtggttggc cggcgcggag atctggctga ccaggagagt
911341 ctgggcaagg tgagcctggg cgagctggtg atcgacgaag gcacctacac cgcccggctg
911401 cgtggccgcc cgctggatct cacctacaaa gagttcgagc tgctgaaata cctggcgcag
911461 catgccggcc gggtgttcac tcgggcgcag ctgctgcacg aagtatgggg gtatgacttc
911521 ttcgggggca cccggactgt tgatgtgcac gtgcggcggt tgcgggccaa actcggcccc
911581 gagcatgaag cgctgatcgg cacggtgcgc aacgtcggat acaaagctgt tcggccggcg
911641 cgcggccgac cgccggccgc ggaccccgac gacgaagacg ccgatcccgg ccgggatggt
911701 atgcaagaac cactggtcga cccgttgcgc agtcagtgac ggcgcttgac tggcgctccg
911761 ctctgaccgc cgacgagcag cgcagcgtgc gtgcactggt cacggcgaca acagcagtcg
911821 atggggtagc acccgtgggt gaacaggtgc tgcgggaact gggccagcaa cgcaccgagc
911881 atctgctggt ggccggttcg cgaccgggcg gcccgatcat cggctacctc aacctcagcc
911941 caccccgggg cgcgggtggt gcgatggcgg agttggtggt gcatccgcag tctcgacggc
912001 gcggtatcgg caccgccatg gcccgcgcgg cattggccaa gaccgccggc cgcaaccagt
912061 tctgggcgca cggcacgctg gatcccgctc gggcgaccgc gtccgcgctg ggtctggtcg
912121 gcgtccgcga actgatccag atgcgacgcc cgctgcgtga tatccccgaa ccgacgatcc
912181 ccgacggggt ggtgatccgc acctacgcgg gcacgtccga cgacgctgag ctactccggg
912241 tcaacaacgc cgcgttcgcc ggacacccgg aacagggtgg gtggaccgcg gtccagcttg
912301 ccgagcggcg tggcgaggcg tggttcgatc cagacggcct gatcttggcc ttcggtgatt
912361 cgccacgtga acggcctggc cggttgctgg gtttccattg gaccaaagtg catcccgatc
912421 acccgggatt gggcgaggtg tacgtgctgg gcgtcgatcc ggcggcgcag cgccgcggtc
912481 tcggccagat gttgacgtcg atcggtatcg tctcgctggc ccgtcggctg ggcggtcgga
912541 agaccctcga ccctgcggtc gaacccgccg tgctgctcta cgtggagtcg gacaatgtgg
912601 cggccgtgcg aacctaccag agcctgggct tcaccaccta cagcgtcgat accgcctacg
912661 cgctggctgg cacggataac tgaccgaaga tgttcccccc caagaagtcg taagcaggag
912721 cttaagtggc caagcggttg gacctcacgg acgtcaacat ctactacggg tcatttcatg
912781 cggtcgctga tgtgtcgctg gcgattctgc cccgcagcgt cacggcgttc atcggtccct
912841 cgggctgcgg caagacgacg gtgctgcgca ccttgaaccg gatgcatgag gtcatccccg
912901 gagctcgagt cgagggtgcc gtactgctcg atgatcaaga tatctacgcc cccggtatcg
912961 acccggtcgg tgtccgccgg gcaatcggga tggtgtttca gcggccgaat ccattccccg
913021 ccatgtcgat tcgcaacaat gtggttgccg gcctgaagct gcagggtgtg cgcaatcgca
913081 aggtgctcga cgatacggcc gaatcctcgc tgcgcggcgc aaacctgtgg gacgaggtca
913141 aggatcgact ggataaaccc ggcggcggat tgtctggggg gcagcagcag cggttgtgca
913201 tcgcacgggc aatcgccgtg caacccgacg tgttgctgat ggacgagccc tgctcctcgc
913261 tggacccaat ctccaccatg gccatcgaag acctgatcag cgagctcaag cagcagtaca
913321 ccatcgtcat cgtcacccat aacatgcagc aggctgcccg ggtgagtgat cagacggcat
913381 tcttcaacct ggaagcggtg ggaaagccgg ggcggctggt agagatcgcc agcaccgaga
913441 aaatcttctc caacccgaac cagaaggcca ccgaggacta catctccggg cgcttcggct
913501 aggcccgatg ccctcgatgg ccaggctggc gtcaccgcgg gtggatgttt gctcggccta
913561 gggaaaggcg ccggtcgcct ggaagatcac gcgtcgtgcc acttccacgg cgtggtcggc
913621 aaagcgctcg tagaatcggc tcagcaacgt cacgtcgacg gcggccgcca ctccgtgctt
913681 ccattcgcgg tccatcagca cggtgaacaa atgccggtgc aggtcgtcca tcgcgtcgtc
913741 ttcttcgcgg atctgggcgg ccttttccgg gtcgtgcgac aacacgacct cttgggcact
913801 gttgcccaat tcgactgcaa ctcttcccat ttcggcaaaa taaccgttga cctcttcggg
913861 cagcgcgtgc tgtggatgcc gacggcgggc gatcttggcg acatgcagcg ccaacgcccc
913921 catccggtcg atgtcagcca ccatctggat ggcgctcaca atggctctga ggtcaccggc
913981 gaccggtgcc tgcaacgcca gaagaacgaa tgcactctcc tcggcccggg cgcttagcgt
914041 cgcgatcttt tcgtggtcgg agatcacttg ctcggccagc acgagatcgg cctgcagcaa
914101 ggcttgggtg gcccgctcca tggcgatgcc tgctagcccg cacatttccc cgagacgctc
914161 ggataattcc gagagttgct catggtaggc ggtccgcatg tgctaaagcc tacgttcccg
914221 accttggaaa atgccgtaag cgtcgtgtca atgcggctac tcgcaggtgg tgtcggcggc
914281 gttggtgacc gtcaggtcct cgggcagctt ggtcggtggg ctggaggagt tgcggcttat
914341 ctgcacgctg acggtggagc cactcggcag gggagcgcgc accgcgctga agtcttggcc
914401 cagcaccacc tggaccagtt ggccgatccc ggtcacccgc tcgatctttg actggccgaa
914461 cacggcggcc acggtggcgg cagcctgttc gttgccgggc gaaaaaaaca ctgtggtggc
914521 cagcagcgaa ctcgggtagt cgtccggagc catcacgttg aagccgttcc gcttgagctg
914581 atcggtggcg gtggtggcca aaccggcctg gccggtcgag ttagagacct gcactgtgac
914641 ctcttttggc gaggtcgtcg taacctgctg gtgctgaatc tcgttggtca gacccgcctg
914701 cggcgccttc ttggtggtgg tcggcggggt cgacggcgtg ttgcccagac gctgggcgtt
914761 gtgatcgttt tccaggggca gcggatcgtc gtcgatgatg gcggtgaaaa gcgccttcat
914821 gtcggaggta cgcgggggct cgtcgccgtt ctggtcggtt ataccggtcg gaacggtcac
914881 gaacgtgacg tgcccggccg ccatatgctg caacgatcga ccgagttcga ccaggtcttt
914941 ggtcttgacg ttgtccacgt agctgttacc gatgaacatg ttgacgacgt tgttgagcct
915001 gctgaggttg aacaaggtgt ccgtcgagat catcgaacgc agcagcgacg acaaaaacaa
915061 ctgctggcgt ttgatgcgcc cgtagtcgcc attgctctcg gtggtgacct ggcgagcgcg
915121 cacatagttc agcgcggtcg gcccgtcaat gacctggcgt ccggcgtgct ccagcaccgt
915181 gcccagttcg tagtcccgca acggggtggt gctgcatacc tcgacgccgc cgagggcctc
915241 gaccatccgc gcgaaaccga cgaagtcaat cgcgatgaac cggttgatgc tcaagcccga
915301 cagtttctga atgaccttca ctagacactt aggcccgccg aaggagaatg ccgagttcag
915361 cttggtctcc gtgtacacca gtctgggacc catcgttccc gtcttctcgt cgtagatggg
915421 tccgtactta ccggtctcgg ggttccacgc ctcgcattgg attggagtga tcgccaggtc
915481 gcgggggaac gacaccgcga cgacccgctc gcggctggcc ggaatgttga ccagcatgac
915541 ggtgtccgaa cgtgcgccgc cggcgtcctc ggcgtcgccg gcgccgatat tggcgttcgc
915601 cccggcacga gagtccatac cgacgagcaa gaagttctcg tcgccatgct gcccgctggg
915661 gttgacgatg tcgcccgaat gcgggtcgag cgcgcttacc atgttcagcc ggctgttctt
915721 cgacgcgctc cactgccatg ccccgccggt cagcgccaac gccagagcgg caaacagagc
915781 cgccagcgag cgcgcggcca gcaccatcgg gcgccggccg gagttcggcg ctggcttggc
915841 gggcgcgggc gacgttcggc ggatccgcaa tggccgcact cgagccgatc cggttagctg
915901 cttgccgggt agctcgggtt cacggcgggc gtggtcggcg cgcggatagt tggctgcccg
915961 gaggtcggga agctccgaga ggaactcgag cgagtgggcc gggatggcga tagcctcggt
916021 gtcctgctgg tcgtcggcgt cgtcgtggac cttcgggccg cggccggatg gctcgggttc
916081 gggggcgaca tggcggtgcg tggggaggtc aggaaaagcg gggccgagcc tggcgatcag
916141 atcggccaca ctaacggcgc cggtggcatg acagccgaca ttctgggtgt cccgcggacc
916201 ctgggctgcc acccatgtgg cgggcggtac cgtgatccat cggtcaacac catcggggaa
916261 tgctgactcg gagagccgtg cccacggcgc ggcgctctcg ccgtcactca tgtcctaccg
916321 gcctccgaga gtctaggtgg cggacgcccg cggtgttggc tgcgtgtcct acgcgcacct
916381 tcgcgcagca ccgccacgag tcggcgccgc acaatgcagc aaggcccaca tcgtactgat
916441 ttatcggtcc agacgcgatt tcgacagggt ctcgattcag ccacccgacc ccatggcgtc
916501 cgccccttcc ggcactcggc agtcgtcggg gtcggttagc cagccgtcgg gaagggccac
916561 ccgggcgggg gaaccctgcc ggccccgggc gccagtcgcg gagtccggga acggtaccgt
916621 gccgtccaac cggtccagca ggcagtcgag ctcgtcgaac gtcttgacca ttgctaacgc
916681 ccgccggagc gcggagcccg ccgggaagcc atggagatac caggcgatgt gcttgcggat
916741 atcgcgcatg cccttgtcct cgccgaagtg tgcggccagc aaggtgccgt gacggcggat
916801 gatgtcggcg acttcgccga gcgtgggtgg ggtgggggcc gggctgccgg tgaaagccgc
916861 ggacaactcg gcaaatagcc agggacggcc caggcagcca cggccgatga ccacgccgtc
916921 acagccggtg gtggacatca tggccagtgc gtcgccggca tcgtagatgt cgccgttgcc
916981 gagcaccgga atcgtccgga catgctgctt gagccgggcg atctgttccc agtcggcggt
917041 gccggaatag cgttgtgccg cggtacgggc gtgcagcgcg accgcagcgg ctccttcggc
917101 ctcagcgatg cggccggcat ccagatgtgt gtggtgggcg tcatcgatgc caatgcgaaa
917161 cttgaccgtc accggtatat cggtgccttc ggtggcgcgc acagccgcgg ccacgatctg
917221 accgaatagc cgccgtttga acggtagcgc cgccccgccg ccgcgcttgg tgactttggg
917281 cactgggcag ccgaaattca tgtcgatgtg atcggctaac ccttcgccag cgatcatccg
917341 agcggccgca tacgtggtgt ccggatcgac ggtgtacagc tgcagcgagc gtggtgattc
917401 gtccgcggag aacgttgtca tgtgcatggt gaccgggtgc cgctcgatga gcgcacgtgc
917461 ggtcaccatc tcgcagacat acagtccgct gaccgtgccg accttcgact gttccagctg
917521 acgacacagc gcccggaatg cgacgttcgt cacaccggcc atcggagcca gcacaaccgg
917581 gctggcgagc tcgatcgggc cgatgcgcaa cgccgggctg ggttggattg cccgcctcct
917641 gctcatcgcg ctgcgcgctc tgcatcgtcg ccgggctggg ttggattgcc cgcctcctgc
917701 tcatcgcgct gcgcgctctg catcgtcgcc gggctaacga cggctcatcg ccagtttgcc
917761 agcggtttta tgcagctcgt gtgcgctgac cttcttgccc gtacgggctt cccggtcgag
917821 ttggcgttgc ttggacacct cgaacttgtc gcaggccagc tcgaggtcct tgatcaccag
917881 ggccagctcg tcgcgcagct tagccccctc gccggtgaag tcctcgcgct cgaagatacg
917941 ccatttcttc agtaccggca tgacgacttc gtcgaggtgg atgcgcgggt cgtagacacc
918001 cccgacggcg atgaccacgg ctttgcgccg gaactcgggt acttggaagc cgggcatctg
918061 gaagtggctc aaaatcaggt gcagcgactt catggcctgg ttgggcacga ggtcgaacgc
918121 ggcctcgctg acgtcgcggt agaagatcat gtgcagattc tcgtctgccg agatcttggc
918181 catgagctgg tcggcgacgg ggtcgttaca tgccttgccg gtattgcggt gcgaaatccg
918241 ggttgccagt tcctggaaac tgacatagag gacggagtcg gtgaggctct ccgcgaaata
918301 gtggccctgg tggttttggc ctgggctgaa gccccggttg actacctcga ggcgaagttt
918361 ctccaactcg acagggtcga ccgatcgggt caccaccagg tagtcgcgca gcgcgatgcc
918421 gtgccgattc tcctcggcgg tccaacggtt gacccactgc ccccacgcgc cgtccatgcc
918481 catgttcatc gcgatctcgc ggtgatacga cggcaggttg tcctcggtga ccaggttctg
918541 caccatcgcc acctgggcga catcagaaag cttgctctgg tcggggtccc aatcctgccc
918601 gccgagcgcg tagtagttct tcccgtccga ccacgggatg tagtcgtgcg ggttccaggg
918661 cttgtgcatg ctcaggtgcc ggttcaggta cttctcgacg accggttcaa gttcgtgcag
918721 cagctgcagg tcggtcagct tggctgacat ggcgcctcca gttatctgtg tctaatggtt
918781 gcagtcaata tatctgtgtc tctcggtagc atcaagtttg ggcttcgcgc ggcatgttga
918841 gctgccagca gcgggcagga tgctggcatc ggcgggcccc ggtggccgcg tggggtgaac
918901 cccagtcgtc ctcagttgtg cggcccggct gggatggagt gttcggattc tccccgctcg
918961 cggtgcggtg cgtaggtggc ggcggtgctg agcaacatgt tgacgcagta gtcgatgaat
919021 tgcttgcggg tggctcccag ccgtccgttc agatatgcgg tgaacagacc ggtaagagcg
919081 ccgatcaagc tggtggcgac cagtttctgc agaactggat caacgatgcg ggacaacttg
919141 cgttgcagca actcgatgaa gttgggcatc cactccgcgc ccgaccgggt cagggccggt
919201 tctaccgccg gcgccagcaa cagcacgcgc ccgcgcaccg gatcgtcgac catcagctcg
919261 acgaattgct ctacggcctc gcgcggggtt tgcgcggacg tgagggttgc catcgctcgt
919321 gtgcagacgt cgtcgtagac cgcgcgaacg aaatgttcac ggtcggcgaa gctttcgtaa
919381 aagtagcgtt ctgtcaggcc ggcgtggcgg cacactgcgc ggacggtgag tgcgggtccg
919441 cctgcgccgc cgagcaactg cacgccggcg gcgacgaggt tgtctcgacg tagggcgtgc
919501 cgactttcca aggggacacc ggaccagcgg ccccggtttt gaccggtctg cacagctctc
919561 ctaaactcca tagtgacaac gtgcgtagtc agaattcgtg tggccaatga agattcagca
919621 ggcaaaacca ccagtgaccc aagatacgtc tgctacctgt ccgctgacca gcaccgtgca
919681 ggattcctcg ccggttgcgg gccagcttgg caggcctata gggttccgcg gactggccgg
919741 cggttgcccc gtgtcaccgc tgggttacga atcgccgccg ctgccgctgg ggccggattc
919801 gctgacgtgg cgatacttcg gtgactggcg cgggatgctg cagggaccgt gggcgggatc
919861 catgcagaat atgcatccgc agctgggcgc ggcggtcgaa gatcattcga cgttcttccg
919921 ggaacgctgg ccacggctgc tgcggtcgtt gtacccgatc ggcggagttg tcttcgacgg
919981 cgatcgagcc ccagtcaccg gtgtgcaggt gcgtgactac cacatcacca tcaagggtgt
920041 cgacggtgcg ggccgtcgct accacgcgtt gaatcccgac gtcttctact gggcgcacgc
920101 caccttcttt gtcggcacgt tgcatgtggc cgagcggttc tgcggtggcc tgaccgaggc
920161 gcagcggcgc cagctatttg acgagcacgt ccagtggtac cgcatgtacg gcatgagcat
920221 gcggccggtg ccggcgacct gggaggagtt tcaggactac tgggaccaca tgtgccgcaa
920281 cgtgctggag aacaacttcg cggcgcgtgc cgtgctcgac ctgaccgaac tacccaaacc
920341 gccattcgcc caacgagttc cggattggct gtgggccgcg ccgcgcaagt tgctggcccg
920401 gttcttcgtc tggctgaccg tcggactcta cgatccgccc gtgcgcgagc tgatgggcta
920461 ccggtggttg cgccgcgacg aatggttgca ccgccgcttt ggcgacatcg tccggctcgt
920521 ctttgccttg gtgccattcc ggtttcgcaa gcacccgcgg gctcgcgccg gctgggaccg
920581 tgccaccggc cgcatccccg ccgatgcgcc gctagtacag acgcccgcgc gcaacctgcc
920641 gccgcccgac gagcgtgaca acccgacgca ctactgccct aaggtctgac cccggacctg
920701 cggcgcaacc ggggcgtggt tgtgctcacc gttaattggc ttacccgaca tccttggtag
920761 ccgatgcctt agcgaccgac tgcagtccgc cggcagcacg gtggtggcgg ggaatcccgg
920821 gaccggcgtg ctcggcgttg aaaacggcgt cgatgacgag ctggcgcacg tgctcgttct
920881 ccagacggta aaagatcgtg gttccatcgc ggcgggtgcg caccagccgc gccattcgta
920941 gctttgccag gtgctgggag accgacggcg cgggcttgcc cacctgctcg gcgagttcat
921001 tgaccgacat ttcgcggtct gccagcgacc acagcacctg cacgcgggtc gcgtcggcga
921061 gcattcggaa cacctcgacc accaagcaga cctgatcgtc aggcaacggg tcaggtccac
921121 tatctgcgta catacgcaaa caatagaacg cgggcgtggt gggctgtcaa ggtcgcgggt
921181 cggcgcccgc tcagcccgtc ggagcggcga tcgcgctgcg ctcaccgccg ttgggttcct
921241 gccggaaccg gtagacatcc accgcgccag ccctgatatc gggccggtgc tcttggcgca
921301 tcggcaggcg ccggtcctgc cattccttgg cgaactcgtc gtagaaggtg gcgggctcga
921361 agtacctgcg gtcatcgacg taatgcggtt cataggcgtc acgcgacgtc aggaagacaa
921421 cctcatcggg tgagcagtag tacagcgatc catagcacat cggacacgga tgggccagca
921481 cgttgagagt ggtaccgacc aggtgctcag tgcccagctt ggtgcacgcg gcacggatgg
921541 caaggctctc ggcgtgggcg gtcggatcat tggtttgggc ccatcgtcga aaacctgcca
921601 tgcctgccgg catgtgcaag acatcggctg ggacgaaaaa tggcaatgcg acggctgttc
921661 gatcacgcac caacgtgacg acaacgccgc gatcaacctc gcacgctacg aggaaccacc
921721 tagcgtcgtc ggcccagttg gggccgccgt caagcgtgga gccgaccgta agaccgggcc
921781 tggcccggcg ggtggccgtg aagcgcggaa ggcaaccggc cacccggctg gcgaacaacc
921841 ccgagacggg gtgctagtcg cgtgaccact aaagatcact cacttgcaac ggtagttcgc
921901 agtggagacc acggtagtag ctagactatc tacatttatc gcatatccgt tttgcttgag
921961 ggggcaacga tggtacgcgc cgatcgtgat cgctgggatc tcgcgacgag tgtcggggcg
922021 acggctacca tggtcgccgc ccagcgcgcg ctggctgccg acccgcgata tgcgctgatc
922081 gatgatccat atgcggcgcc gttggtgcgt gccgttggta tggacgtcta cacgcggctg
922141 gtggattggc agatccccgt cgagggggat tccgagttcg atccgcagcg aatggccacg
922201 gggatggcct gccgcaccag gttcttcgat cagttcttcc ttgatgccac ccacagtggc
922261 atcggccagt tcgtcatcct ggcgtccggg ctggacgccc gggcttaccg ccttgcctgg
922321 ccggtgggca gcatcgtcta cgaagtggac atgccggagg tgatcgagtt caagaccgcc
922381 acgctgagcg atctgggcgc cgagccggcc accgaacgcc ggactgtcgc ggtcgacttg
922441 cgcgacgact gggccaccgc acttcagacg gcgggttttg atccgaaggt gccagcggcc
922501 tggagtgctg aagggttgct ggtatacctg ccggtcgaag ctcaggatgc gctgttcgac
922561 aacatcaccg cgttgagtgc tcccggtagt cggctggcgt tcgaattcgt gccggatacc
922621 gcgatttttg ccgatgagcg atggcgcaac tatcacaatc ggatgagcga gctcggattc
922681 gacatcgacc tcaacgagct ggtgtaccac ggtcagcgtg gtcacgttct cgactattta
922741 acccgcgatg gctggcagac ctcggcgctt acggtcacgc agttgtacga ggcaaacggc
922801 tttgcctatc ccgacgacga gctcgcgacg gcgtttgccg acctcaccta cagcagcgcg
922861 acgctcatgc gctaaagcaa gcgatctgac cgcttactgg cgaagcagct catctttcag
922921 gcgactggtg atcatctcct gaaacacgac ctgggccgga ccgtacaggt cctggaatgt
922981 cgacactaag gcgtccctgt tgtactcggg aatggagccg ccactgggag tccaaaagct
923041 atcgatgtcc agcaggaaga atggtccggt ttgggcgggt gttattcggc gcagatggta
923101 attgggatca agcgcttggc ccatacccgg gccgtagcgc acgatgagcg atttgcctgg
923161 ttgtagctca cggtagactg cggcaccctg ccactcggtc aggaccaggc cgccgggagt
923221 gaaacgctgc ggcccgagca gctgctcgtc gatccagttg ctccacgtga tccggccgtc
923281 gacacccgcg gggacgcgga tctccagaac aaagcgaaga ccgatacgct ccaacccaac
923341 gattgacgag acctgcgcgc gagcatccac gacccgcatc acaacgtcgg taaaggcctc
923401 aaagctgcgg taggcggtgg tctccacgac tatcgcctgg ttcttcagtg aagcggcggt
923461 ggtgttatcg cgattgacat aacgaacgaa acgatccgcg accggggtgg gggctccacc
923521 gggcgccgtc atcccccagc tgacgtcctg cgcctggcgt tcgatcggta gatcattgat
923581 aagcaggtgt ttgagctccc ggttcgctga ttcggtgagc gaatccgttg tcgggtgacg
923641 gatttccacc gtcaccaggg caacgggtgc gttgggctgg acctcatcct gatttgtctc
923701 ggggagcata gacagcaagc atagccaggt tgctttgctc agatcgccgg accgtgcatc
923761 gggagggaat cggcgatgcg cacggcttcg tgcccctgtt tgtgccccca ccaggactcg
923821 aacctgggac ctgcggatta aaagtccgta gctctaccaa ctgagctata ggggcgcgaa
923881 gactcaggat actgcgttgg cgtcggccgc tcgtttgagg aataggctgg gggtgaccta
923941 agctggcgtg gctcccaacg gtcaccacgt tgcgagtgcc ccggagagat tcggttctgc
924001 ccccttcgtc tagacggcct aggacgccgc cctttcaagg cggtaacgcg ggttcgaatc
924061 ccgtaggggg tacctgcgac gcggtatcgc ggagcacaca acacagcaag gccctgtggc
924121 gcagttggtt agcgcgccgc cctgtcacgg cggaggtcgc gggttcgagt cccgtcaggg
924181 tcgccaggac ggtgaggcac atgctgcctt ccggccaggt agctcagtcg gtatgagcgt
924241 ccgcctgaaa agcggaaggt cggcggttcg atcccgcccc tggccaccat ggtctacctg
924301 gataggcact gtggcggcac tgctacgtag ccgacctccc tgggtctggg tgattggtcc
924361 cgggctgcga tggtcgtgag cacacgcccg gatcaccgat gccgtcccgc cccggtaggc
924421 catcgcggcg atgatcgaga ttgccggccg ggttgatcgc tgcggattcc acccgggtcg
924481 aacggcgggt ccatctgctc ctcgatcgct cgtgaaagac ctgattgttc agccatttcc
924541 agcatcacag gcgccaaacc cattggccga catcaaattc cgctcgtcaa ccaccgccgg
924601 ctcggtggtg aacgcatgca gtgaatgggt caaaagtgtg gtcttggact gtagagaaat
924661 gcgacgtgag cgctggtgtt gtcccaggcc agaaggccca gaagacttgt cgcggttcgc
924721 acgccgatcg agtcaccgga ccatccatgg gcgatgcgcc ggaaaaccag acgcgcgcaa
924781 gcctcgaagg ccttggcgtg gcgaagggcc gccggctagg gcaaccctcg tattcccgga
924841 tgttggcggc ccgacgggat tacactgctt cctgctgatt cctccctgcg atcggtcgat
924901 cgcaggatcg gttggcatcg aggtcatgtc gctgtgggag gagatgtcgc gtgtcttatg
924961 tgagcgtgtt gcccgctacg ctggccacag cggcaacaga ggtggcccgc atcggctcgg
925021 cgctcagttt ggctagcgcg gtcgcggcgg cccagaccag cgcggtgcag gccgcggccg
925081 cggatgaggt gtcggcggcg atcgctgcgc tgttttccgc ccacgggcgg gattttcagg
925141 cgctcagcgc gcgggcggca gcgtttcatc acgagtttgt gcaggccctg gccgcgggtg
925201 cggggtccta tgcggtcgcc gagattgccg ccgcatcgcc gttgcagagc ctgatcgacg
925261 tgttcaacgc gcccatccag gccgccaccg ggcgcccgct gatcggcaac ggcgccaacg
925321 gccagccggg caccggggcc ccggggggcc cggcgggtgg ttgatcggca acggcggggc
925381 cggcgggtcc ggggcgcccg gcgccatcgg tggggccggc gggcccgcgg ggttgatcgg
925441 tgtcggaggt gccggcgggg ccggtggaga ctccgcggtc gcgggtgtca tcggaggggc
925501 cggtggggca ggcggggctg ccctgctgtt cggtgccggt ggggccggcg gggccggggg
925561 ttccggcggt tccggcgcag ctggtggggc cggtggcgcc ggtggggccg gcgggctgtt
925621 cgccagcggc ggcagcggcg ggttcggcgg gttcgcatcg acgggcaccg gtggggccgg
925681 cggcaccggt ggggctggtg ggttgttcgc cagcggcggg gtcggcggta ctggcggggg
925741 agccgggtcc ggcggtaccg gtggggttgg tgggacgggt ggggccggag ggctgttcgc
925801 tagcggcggc gctggcgggg ccggcgggtc cggcggtacc ggtggggctg gtgggacggg
925861 tggggccggc gggctgttcg gagccggtgg cgctggcggg ctcggcgggc aaggcaacca
925921 caccggcggg cacggtgggg ccggtggcag cgccggcctg ctcgcccttg gcgacggcgg
925981 cgctggcggg gccggcgggg ccgctaccac cggaaccggc ggggccggcg gggcgggtgg
926041 caaggccggc ctgctgttcg gctccggtgg ggccggtggg tccggtgggg ctgccggcac
926101 cttcggtgac accggtaact ccggcggggc cggtggggcg ggtggcaagg ccggcctgct
926161 gttcggctcc ggtggggccg gtgggtccgg cggcgctggg ggcttcgcca acggctctac
926221 cggcggtgcc ggcggggccg gcggcggggc cgggctgatc ggcaacggcg gcaacggtgg
926281 cagcggcggc acgtcggttg ccaccggggg ggccgggaac ggcggtgccg gcggcgccgg
926341 cggcggggcc gggctgatcg gcaacggcgg caacggcggc agtggcggaa tgggcgatgc
926401 cccgggcggc accggcgtcg gcggcatcgg tgggctgttg ttgggtttgg acggcgccaa
926461 cgccccggcc agcaccaacc cgctgcacac cgcgcagcag caggcgttgg ccgcagtcaa
926521 cgcgcccatc caggccgtga ccgggcgccc gctgatcggc aacggcgcca acggcgcccc
926581 gggcagcggg gcccccggcg ggcacggcgg gtggttgttc ggcggcggag ggaccggcgg
926641 gtccggcgtc agcggcgggg cgggcggaga tggcggggcc ggcgggatct tgttcggcgc
926701 cggcggggcc ggcggcgcgg gcggggccgt cacgggaacc ggcgccaccg gcgggtccgg
926761 tggggccggc ggtggagcct tgctgtttgg ggccggtggg gccggtggag ccggcgggtc
926821 cagcgggatt ggcgggttcg ccgcgggcgg ggccggtggg cccggagggg ccggtgggct
926881 gttcaacggc ggcggggccg gcggggccgg cgggtccggc gtcagcggcg gggctggcgg
926941 ggagggcggg gccggcgggg ccggtggcct gttcgccggt ggcggggccg gcggggccgg
927001 cggatcgggc aacaacgtcg ggggggccgg cggggccggt ggggtcggtg ggctgttcgg
927061 ggccggcggg gccggcggat ccggcggcgg cggtagcgtt gctggcgaca gtggggccgg
927121 cggcaacgcg ggcttgctcg cccccggtct cgccggcggt gccggcggtg gcggcgggca
927181 gggttttgac accggcgggg ccggcgggcc cggcggcgac gccggcctgc tggtcggctc
927241 cggcggggtc ggaggtgccg gcggattcgg cctcactacg ggtgggcctg gggcggccgg
927301 cggcgacgcc ggcctgctgt tcggctccgg cggcgctggc ggggccggcg gctccggccg
927361 aaccgacctc ggcggcgctg gcggagccgg cggcaaggcc gggctgatcg gcaacggcgg
927421 taacggcggg gccggcgggg ccggcgggaa cggcggcggg gacggcgggc ccggtggagc
927481 cgccttcggg ctcggtaacg gcggcaacgg cggcaacggg gggaccggca cgtccgcggg
927541 cagccccggt gccggcggcg ccggtggttc gctgatcggc gcggaggggc tgcccgggct
927601 gctgccctag ccggcccggt tggaccacgt gatcgacgac cgtcacaagt cgacacgccg
927661 aacgtgcaac cacggcggca tcacctggcg tgtcgccgcc accagcgcac gctcggcacg
927721 gagtttagca actactcatc cagaagccgg ccactacggc ctggccacct ggtttacccg
927781 catggacgcg atgaccgcac cgacctgagt cggcattgct ggttgcgctc atccggttat
927841 ggcaagccgt tctgtcccgg cgcgccaaac accccggcct tgccaccggt accgccggct
927901 ccgccgttga cgccgttgcc gccgttgcca ccgtagccga gggtagacgg ggcgagcatg
927961 ccgttgacaa ctatcgtcgt gtcgccgccg ttgccgccgg tgttagcccc gaagccggtg
928021 ccggcgttgc cgccgttccc acccacgccg actagtccga gggcgtcgcc gccgttgccg
928081 ccagcgccac cgttaccggt gggggcggcg ccgccggcac cgccggcacc gcccacggcg
928141 atcccaaccg ctacggcctc gccgccgtcg ccgccgtcgc cgcccatgcc gcccagcacc
928201 cccagggcgc caccaccgtc gccgccggcg ccgccgatgc cgatgcccag gatcacgggt
928261 gagctcaacc cgccaccgcc accggccccc ccgttgccgc cggtcccggt ggcggtgccg
928321 ccagctccgc cggcgccgcc gtgcagcacg gagaacccta ggaagtttgc gatgccagcg
928381 ccggcgccgc cgaagccgcc ggctccgccg gtggcgccgt ccccggtggc ggcaccacca
928441 gccccggcgg cgccgccaaa gcctaggccg aggacagcaa tgccctcgaa gacgccgtca
928501 ccgccggctc cgccggtggc gccgctagtg ccggcgccgc cctgcgcgcc cgcaccgccg
928561 atggcgatgg cgatcccgaa ggggctgctg gcggtgcccg tgccacccgg accgccgggt
928621 ccgccgactc ccgtggaagc gtcgccgccg gcggctccag cgccgcccag ggcaaagatc
928681 aggccgcggg cgctgccgcc agcaccgccg aacccgccgg ttccgctggt ggcgtccccg
928741 ccggccgcgc cggccccgcc gacggccgcg agtgcgccgg tagcgctgcc gccgttgccg
928801 ccgttggcgc cgttaacccc gactccggtg ccggcgttgc cgccgttgcc acctgcgccg
928861 acgaatccga agccgtcacc gccggcaccg ccgctgccgc cggtaccaac cgaagccccg
928921 ccgccgtgcc caccggcgcc gcccacgccg cccagcagcc cggtcccgct gcctccggcg
928981 ccgccgttgc cgccggtgtc ggtggcggct ccgccaaccc ccccgacgcc gccgatgccg
929041 gcgccgatca atccgagggc atcgccgccg gtcccgccat ggccgccgct accagccgaa
929101 gcggcgccgc cgggaccgcc ggcgccgccg gcgccgccca gcagcccgac gcccaatccg
929161 ccggcgccgc cgatgccgcc ggtctcggtg gcggccccgc cagccccgcc ggcgccgccg
929221 acgcccacgc ccagagccgc gaagccgccg gcaccaacgc caccggtccc gccggtgccg
929281 ccggcaccgg tcgcagcccc accaagcccg ccggccccgc cgtaggccgc gccgaacccg
929341 atgaagtcgg gggcaacagc gaagccgcca gtgccgccgg ccccgccggt cccagtggta
929401 gctgcgccac cattgccgcc agcaccgccc cagctcaagt cgagcgcgaa aacggtgccc
929461 gaggaaccgc cggcaccgcc ggcgccgccg gcaccgccgt tagtacctgc gccgccgtgc
929521 ccgccggcac cgccgatgcc gatgtcgatc ccgaaggggc tggcggcgcc accagagcca
929581 ccggcaccgc cggcaccgcc gcttcccatg gccgagtcgc cgccctgacc gccggacccg
929641 cccaggccaa ggaacagccc caatgcgttg ctgccggcgc cgccggcacc gccggttcca
929701 gtggtagcgg ccccgccggc gccaccggcg ccaccgatgg ctaccagcgc gccgccggct
929761 ccaccggcgc cgccgacccc gccgttcccg actccgctgg cggccccgcc agctccgccg
929821 ttgccgccaa tgccgaacat cagcgcgttg ccacccgccc caccggaccc gccgccggac
929881 ccgccggccc cgccagctcc gccgctaccc cacagccacc cgccggtgcc gcctttgcca
929941 cccgaggcgc cggtgcctcc ggccccaccg gtcccgccat ggcccagcag cccggcggca
930001 cccccggcac ccccggtctg ccccggagca cccgaaccgc cgttgccgcc gttgcccaac
930061 aaccagcctc caggcccacc ggcctccccg gtccccgggg cgccgttggt gccgttgccg
930121 ataaaaggtc ggcccgacaa cgcggcggcg ggtgcattga tggcgcctag caagccctgc
930181 tcgagggtct gcaacggcga cgcgttggcc gcttcggcgg ccgcataggc gcccatagcc
930241 ccggccagtg cctgcacaaa ccgggcatga aacgccgccg cctgcgcgct catcgcctga
930301 tactgctgac cgtggctgga aaacaacgcc gcgatggccg ccgacacctc atcgccagca
930361 gcggccaaca gcccgcttgt cgggacggcg gccgccgcat tggcagcggt cagggacgcg
930421 ccgatgcctg caagatcctc cgtggccatc gccaccaagt ccggcgctgc aatcacgaaa
930481 gacatccgac acctcccagc tggccggtgt gatctgactg tcgcccatcg ttacgatacg
930541 cgcatatagc gcctaccggg agacgaagtt gacactcgtc aacatccgat ggccgccgga
930601 gatccggcac ggctcggcgg tcgtttgggc gggcgttggc cccgcacgtt cgacagattc
930661 gacaagttcg tgcgcctcgc gcaacgagac aaccggcgac gccgcctaag gtcaagggcg
930721 gcgtgcgtta gcacttccgt cactcttgtc aattagccgc agcaaacgcc agtcgcccgt
930781 acgatggcgg caacggcgtc ggcggagcgg tttcccgctt ggccaacgcc gaagtcccag
930841 catgaccgat cgcggacgcc agtccgcaga agccggctta tcgacaatga ggccaaagag
930901 ctcaacccgt cagcggacat gtggcgcgcg ctggccagtg tggcgatcag tcgtgtgttg
930961 ctccactgct gccaagtcgg ccgtcatcgt ctgctgtgcg gccatcgcga ccacggcatg
931021 ctcgtttcaa gccacatcga cccagccgag caccgcaccc ccgacatcgc gggtcgattc
931081 gttgatcgtc agcatcgaag acgtacggcg catcgccaac tatgaggagc tcgccgcaca
931141 ttttcagacc gacttgcgtg aaccgccgga ggcggacacg aacgttccgg gcccctgtcg
931201 tgtggtgggc agcagtgatc gcaccttcgg aaccgactgg tcagagttcc gtagcgcggg
931261 ttaccacggc gttaccgacg acctcagacc gggcgggccg gtcatggtcg agacggttag
931321 ccaggcgata gcgctgtacc cggacccgag tacggcgcgc ggtgtgttcc atcggctcga
931381 gtcgtcgctg gcagaatgtg ctggcttgca tgacccctac ttcgatttca tcctcgacag
931441 gccggacgcc tccaccgtga ggatcggcgc tgcgggttgg agtcatgtgt atcgcctgaa
931501 atcgtcggta ttcatatccg ttggcgtgtt gggtattgaa ccggcagagc cgatcgccaa
931561 cgtcatcttg cagacgatca gcgatcgcat ccagtagtta gccgaggact ggaaagcagc
931621 agcggcggcg acgagcgcag cgtgttgagg gctgttgacg ccacgacgcc caccgttgcg
931681 aagaagaagg cgagaagcgt cgcttcggca ccgactgctg tcaccgcaac cgagctgtaa
931741 ctacggggat ctattggatg cgaggcgtaa tcaagcagcg tggcgatggg tctggtgtcc
931801 accgcaaagg agaagacatg ccatatgggg gaaagcttga cccacgagag cgctgtcccg
931861 aacaactcgg tgcctgtcag aaggatcagc gcactggccg ctatccaggc cgtcaggcgt
931921 gccggggata tcacgacgcc gaatgtcttt cgttggttat cccagactgt cgagcgacgt
931981 tgtttttgca ctgaacgtcg aatcttctga gactgccgcc gctttcgccg gcgccaagtc
932041 tcgggcttac ttaaccaggc gagccgccac cgtacgacag tcgcagtcgc taagacttgc
932101 tgctgcatcc aactcgtggc ggccttcatt gatcccgact accaccctgc ctaaccaatt
932161 ctgtatgacg cgccgtttga gaacgtacat ttgtgattgc ggttcgcatt taggagcccg
932221 gcgtgagctg gtcgagtaac gcctcgacca gcgggcgccg cgaagctgtg gtggtgggct
932281 agcccggtcg acccacggcg aagtgctggg ccagcaggtc gtggtcggcc tgtgtggcgc
932341 gcgtcgccag cacggcggcc tccggtgcgc tgacactggc gcgcatgtcg tggccgagca
932401 gcgcggcagc ggcggtgcgt aggtcgaagt cgtgacggcg tagcgcccac tggtctggtt
932461 tggcgtaaag ccggtcgagg tcgccggcgt accagtgcac caccaaggcc agatctgggc
932521 cgtctttgta gtcgtggtcc gcggaccgat cgagccatgc gtgcagtttg aggaccgcat
932581 agttcggcgg ttggggaagg tggactgtca ggccgccagg gagaggcaga acatcggcac
932641 gcaggtaggc gtcggtgcat ccgtggacgt tcatgagctg gttgcctggg ggatggcggg
932701 ttgtgccggt gggcgactcc acctcgccga acgggagggc atcgacggcg cggtcggcga
932761 tcaggaatcg gtgcccggtg ctgcccaggg cgcggaaggt ggcccgaatt gcctcgaagt
932821 ggtcccaatt gttcagggtc cctgcgatat cggtgtcgtt ggtggcccgc ggcggcaccc
932881 cgcggcagaa gcgccagtgc agtagatcgc ggcactgtgc cccgacgagc atcagctgtt
932941 cagccggcac gacgtcggca agtgctgtga cgatcggtgt cacccaggcc aggaggaccg
933001 ggtcataatc gggcgagtcg ctcatcctgc cttctcatga ggtgggcgac ttcgacctgg
933061 cgcggctcgc gcgaggcaag gaggtcggca tagatcaagg ccgtgggagc caaccccggt
933121 tgctcgtcag gtaggttgcg ccagaatagc tttcggatca cgatgctgcc gtgtgggtcg
933181 cggtgccagc ggttgtgtat aagcaggtcg gcgggtagcc cgggcgctgg ggtgtcgacg
933241 tagagcatca gtgattcggg attgcggatt tcgtcgggca gggcctgttc cccgctgacc
933301 gccactgcga gtccgtcggg tgcggaccac gtgtggatat caccactggc gaccaggagt
933361 ttgttggccc ggcccagacc ccccggatag gcagccgccc acaggtccag cagctcatcg
933421 gtgcgcacca gcctgcggcg ggagccgagg tgttcgaaga agccggtagt gcgcaacgta
933481 tccatcgtct ccttggccat accgaccgag acgccggcgc tcgcggcgat cgcacgcagc
933541 ggcgcgtcga ccagttgcgg tgcgtcaagc agtacgcaga caacctgcgc gcgcttgggg
933601 gtaaacgggt tacgcggtcc atcgctgtgc agtccgtcac cgagggtgcc cggttgtgcg
933661 gacacagctg accgtcggcc gcgcacgtcg atgagcaggc caccctggtg ccgcaaataa
933721 gcgttcccag ctccgtcgat gtaccagagt ccgcgagccc gcagcgtttc agcgctcgac
933781 ggatgcagac gcgggcccac cacaagcagc ggcgaaccag cgccggcggt atcccaggcc
933841 tgcagtgctg ccgttgccga caggtgagga aggtagaggg cagtgatcgt gagggggtga
933901 gcgtcgatct caaggtctag tgattcggga tgcgcggagt tcaatgctga taggccaccg
933961 agcacccgca ctccgtattc ggtgaggtga cgctcgacgg cctcagcgag gtcagccccg
934021 atctgatcca tgcgttcagt atatccgtac gttcagtttt attgaacata atgatttatt
934081 gaacatatca ggtcggagct ggtcgacttg gaaggtgtag cggtatccga gtcgcactca
934141 ctgcctcctg ccatgactca ccccaagggt gcaggttgtg cggcagtctg atgagttgcc
934201 gcagcatcgt tgccgcggcc tcctcgttgc ctgtctgaaa cctcgtctgc agtcgagggg
934261 tggtcagcac gcgccgggcc agacggactg gtctactgcg ccaaagcttg tcgctgcgct
934321 tggaggtcag gccgagcagg cgcgaggaac gacgaaccca acaagccatg gtggttggcg
934381 ccgtcgagag gtcggcggtc gccacaacgg gaagatcgcc ttgagcgtcg ctcgaccgcc
934441 gcctcgagtt gggtcataac gaagtagctg atgccgatca tgtcgacgtt tccgtcgcat
934501 cagcgtgcag cggcgaccca ctcgacgagg tctcggtgcc gccgcggcca gggcaccagc
934561 agtgacgagt ccaggcgccg tcgggccaag cagtcgcggt gccagccgtg gtgggtcggg
934621 cgatggttgg gtgtgctcat ttcgggaacg ccagggcgat cagcgtcggc aaactcgcgt
934681 cgatgtgccc gcggcgcaac aatccgcgac aatgatcggg tgcgtctgat cgggcggctc
934741 cgtctgctca tggtggggct ggtcgtcatc tgcggggctt gcgcatgtga ccgcgtgtcg
934801 gccggccgtt ggtccgagtc gccgagtgcg acctcgtggc ccgtccggcc ggtaaacacc
934861 acaacgccat ccggtcctgt gccgccagtc agcgaggcgg cgcgggcagc cgggttggtc
934921 gatgttcgcg gtgttgttcc cgatgccgcc atcgacctgc gctacgcgac ggcgaacaat
934981 ttcaccggca cacagctgta cccgcccggg gcaagatgcc tggtgcacga gtccatggcc
935041 gagggtctcg cggccgccgc ggcggtgctg cgcccacacg ggcaggtgct ggtcttctgg
935101 gactgctatc ggccccacga cgttcaggtc aggatgttcg atgtggtccc caacccggcc
935161 tgggtggcgc ggccgggcaa gtacgcgcat agccatgagg cggggcgttc ggtcgatgtg
935221 acgtttgcca gcgctcagcg gcagtgccca tcagtgcggc gatccggcga attgtgcctg
935281 gccgacatgg gcaccgactt cgacgacttt tcttcgcggg cgacagcgtt tgcaacgcag
935341 ggcgtcagtg ctgaggccca ggccaaccgt gcccacctgc gagccgccat gcaggccggg
935401 gggttgacgg tgtactccgg tgagtggtgg catttcgacg gccccggcgc cggcgtcgat
935461 cgcccgattc tcgaagtgcc agttgactga cgtctcatat agtgaaataa atgtccacta
935521 tttgggcgca gtggcggtag gctttgagcc gaacacctcg accatgggac cgcacggtga
935581 acgacaaacg tcgggcgatt tatacgcacg gatatcacga gtcggtgctg cgcagtcacc
935641 ggcgacgcac tgcggaaaac tccgccggct acctgctgcc ctacttggtg ccggggttgt
935701 cggtgctcga cgtcggttgc ggccccggga cgatcaccgt cgacctcgcc gctcgggtcg
935761 tgccgggatc cgtgaccggc gtcgagccaa ccgatgacgc cttaagcctg gcccgcgccg
935821 aggcccagct gcaccgcctg tcaaacattt cgttcaccac ttccgacgtg cataagctcg
935881 acttccctga cgacgcgttc gatgtcgtcc acgcacacca ggtgctgcag cacgtcgccg
935941 atccggtacg ggcactacag gagatgaggc gggtgtgtac accaggcggc atcgtcgcag
936001 ctcgcgatgc cgactattcg gggttcatct ggttcccgaa gcttccggcg ctggaccggt
936061 ggttggacct ttatgaacgg gcggctcgag ccaacggcgg cgaaccggat gccggccggc
936121 ggctgctgtc ctgggcccgt gcggcaggat tcgacgacgt cacgccgacg gccagtgtct
936181 ggtgtttcgc gacggcctcg gcccgcgaat ggtggggcct agtgtgggcc gaccggattc
936241 tgcaatccga tctggctcac cagctggtgg attcgggtct ggccactgcc gcgcaactcg
936301 aggagatctc cacggcgtgg cgagagtggg ccgcggcccc ggacggttgg ctggcgatac
936361 cccacggtga aatcctttgc cgggcataaa ctcaggcaca cgcgcgaggc tcgcgcggtt
936421 ggttgccgac gacgggcagg acgtggcccg gcgagatcaa atatcgtgca gccgaaggaa
936481 ttcacgcatc acccggtcga atcgcgccgg ctcttcgatg aacggcatgt gggaactgga
936541 ctcgaagaat tccaatcgcg agcccgcaat ccggccctgc atttctcgca tgtgctcagg
936601 cgaacattcg tcgaaacggc ccaccaccag caaggtcggc accgcgatgt cggccaaccg
936661 gtcgacgacg tcccagtctc gaacattccc aacgatgcga aagtcgctgg gcccaaacat
936721 cgtctcgaag atctcggttc ccatgttggc gaatgcttcc gtgagttccc ggggccaggg
936781 gcgggtgcgg cacagataag tctcgttcca ggttctgatc gcggcctggt attcggcgga
936841 atgggtggtg ccggccgcct cgtgacggtc aattgccgag cgagttgcca cgtccaagca
936901 cgacttcaag ctgaccagac tggccgaaaa ttcgggtatc gaagccgtgc tgttcgcgat
936961 ggtcagactg acggcgtcag gcgccttgtc gagcacgtac tgctgtgcca gcatcccacc
937021 ccacgaatgg ctgaagatgt gaaagcgggt aagggcaagg gcttccgcca cggttgccat
937081 ctcggccact gagcggttca tcgtccaaag gtctacgtct gacggacatg cggaatttcc
937141 gcaaccgagc tggtcccaga agatgacctc ccgctcatca gacaaccgtc gcagtggggc
937201 caagtagttg tgcggcaagc ccggcccacc gtgcactaca agcagcggac gaccaggacc
937261 gccaccaatc cgctggaacc agacgcgtcc acccgggacc gcgattgtcc cctccacttg
937321 acctccgatt tcggttgacc aacagacgca gaatcgcaca ttcgcccctt cgggggagtg
937381 cgagtttgcg tcgcctcgcc gggcatgtcg gtcagcgatg gcgcggtcga gaccagacgg
937441 cccgaggcgg tttgggtgga tcgacagtat cggtcgcgca gttaccggcg gactcggctt
937501 ctgctggccg gccggtcggg tgtgcccgtg cataccgctc tcggcttcac cgtggctgtg
937561 gccgtgtgca caccgggtga gacgcccggt tcgtggttgc ggccagcatc gtgcaccaca
937621 gcgctgcgcc ggccaaccgc ggtcgctacc acggaatctg gtcgatgacc cctgtagttg
937681 cttcggtggt tgtgccaatc atggcttcct acggcccgat tcatggtgct catctcttgg
937741 ccgcggtggt cgtggggtcg gccggtgccg cgctgtgcct gccgttggcg cgggccctgc
937801 gccgaccgac ccccagtgca atgacgacgg attgacggtg cggagcccgg ggatgtgctg
937861 agggcaccaa tgtggtgaaa gttgcacgca agcagcacaa tcggagccca gaatgggcac
937921 tgggcgcaga acccgagccg cagaagtaat gtgctggagg ggttactgca gcaaccacac
937981 ccccgggtgt cctccgatcg ggggaagggg ctttcgtcat cgtttcaggc cgatcggagg
938041 acgccggcac aggtcaacga tcctaacttg agttagtgac cacagcggcg gccatcgccc
938101 gcgaggaccg gttgcgttac accggtccgg agcgctgctc gggggacgga caagttcgag
938161 cggccgggga tcgctattcg acggtgatct ggctgctggg cggcaacttg ctggtgcgct
938221 cggccggatt cggctatccg ttcctagcct accacgtggc tggacgagga catggtgcgg
938281 gagcggtcgg cgcggtcgtg gcggcctacg gcctgggttg ggcggtgggg cagctgctgt
938341 gtgggtggtt ggtggaccgt gtcggggcgc gggtgacgct ggtatccacc atgctggtgg
938401 ccgccgccgt gctggtgctg atggccgggc tacacaccgt gccgggattg ctggttgggg
938461 ccatgatcgc cggcctggtt tgcgatgccc cgcgtccggt gttgggtgcg gtgatcgcgg
938521 agttggttgc cgacccacag cggcgggcac aactcgacgg ctggcgatac ggttgggtgc
938581 tcaatatcgg tgctgcgatc accggcgggg tcggcggtgt ggtcgcgggc tggttggaca
938641 ccccggtgtt gtactggatc aatggcatcg ggtgtgcgat cttcgcgggg ttggcaggcc
938701 gctgtatacc tgccgatgtg tgccgtagga ccgagtccgg ccttcgagct tgcaccgcca
938761 tgtcgaaagt tggctatcgg caggcactct cggacaagcg cctggtcctg ttggccgtct
938821 cgggtctggc aacgctcacg acgctgatgg gtttcttcgc ggcggtaccg atgctgatga
938881 gcgcgagtgg actgggtgtc ggggcgtacg gctgggtgca gttgatcaac gccctagcgg
938941 ttgtcgcggt gaccccgctg ttgacgccgt ggctgagcaa gcagctcgca cttggtccac
939001 ggccagacat tctggccggc gcgggagtgt gggtgactct ttgtatggcg gctgccgggc
939061 tcgcccgcac cacggtcggt ttcagtgtgg ccgcggctgc ctgctcgccg ggcgagattg
939121 cctggttcgt ggttgccgcc ggcatcgtgc accggatcgc ccctcccgcg cacggtgggc
939181 gctaccacgg gatctggtcg atggccgtcg cggcgtcgtc ggtggccgcg cctatcctgg
939241 ctgctttcaa cctggctaat ggtgggcgcc tagtgctggc ggccaccacg gtgacggttg
939301 gtttcttcgg ggccgctttg tgcttgccgc tggctcgtgt tctggcagct gccagttgcg
939361 gtccgttgag cagcaaggag ccgtcgcgtg actcgtacca gtgaagggtt ggctgcgttc
939421 gtggtcgatc agctggagga gctgtatcgc cggatgtggg tgttgcgact gctcgatatg
939481 gcgttggagc agttgcgcat cgaaggcctg atcaacgggc cgctgcaggg tggcttcggc
939541 caggaagcag taagtgtcgg tgccgcggcg gcgctgggcg aaggcgatgt catcatcacc
939601 acccatcgtc cgcatgccca acacgttggt actgacgctc cgctgggccc ggtgatcgcc
939661 gacatgctgg gtgcgaccgc aggcgatcta gaaggcgctg acgaggatgc gcacattgcc
939721 gatcctcggg ccgggctacc ggctgcaata cgcgtggtca agcaatcgcc gctgttggct
939781 atcggacacg cctacgccct gtggctgcgc gacaccggac gggtcacact ctgcgtgacc
939841 caagactgtg atgttgatgc cgatgccttc aacgaggccg cggacctagc ggccgtgtgg
939901 caacttccgg tggtgattct cgtcgaaaac attcgtggtg ccctaagtgt gcacctggac
939961 aggtacacgc acgagcctcg ggtttatcgc cgggctgtgg cctacggaat gccgggggta
940021 tcggtggacg gcaacgacgt cgaagcggtc cgtgactgtg tggccaacgc ggtggttcgg
940081 gctcgcgctg gtggcggccc cacgctggtc caagccatca cctaccgcac caccgatttc
940141 tctggatctg accgcggcgg ctatcgcgac ctggccggat ccgagcagtt tctggatccg
940201 ctgatcttcg cgagaaggcg gctgattgct gctggcacga cccgcggtcg gctcgacgag
940261 caggagcggg cggcatgcca acaggtggcc gatgccgtgg cgttcgccaa ggccagggcg
940321 cggcccaacg gcggtgggcc aatcagccga ccaacatccg gctggcacca acaaccaaag
940381 acccggttct gaggcctaga tgtacgttgg ccgcggacaa cgcggtcggt acatgccgtc
940441 gcgccgcggc cccagctagt cgagcagcct ctgccgcatc gcctcggcga ccgcggcagc
940501 tcggtcgctg acgccgagct tctcgtacaa ccgttgcacg tgggtcttta ccgtcgacgg
940561 cgccacatat agctcggctg cgatcgcggg gatgctttga ccgcacgcaa tgcgattgag
940621 cacctcgcgc tcgcgcgcgc tgagcaccgg ggccacgggt gccgcgcgct ggcgaatctc
940681 cccggcgagg cccccgacca gcgagggcgc caccacgtcg cggcccttcg cgcaatcgag
940741 caccgccttg acgatctcgg tgcgagtcga atccttgagc aggaatccgg cggcgccctg
940801 ttggagtgcc tggtagacga tcgccggctc gtcgtgcgcg gaaataagca gcacccgggt
940861 tggcaactcg tagctgcgca ccgccgccgc aacctgcgcg ccgtccatgc cgggcatgcg
940921 gtagtccagc aatgcgacgt cgggcaaatg ggccttgatc aactccaggg ccgcggcgcc
940981 gtcgtcggcc tcgccgacca cgttcaccga gccactcaac gaaagcgctc gcacaacgcc
941041 ctcgcgaaat aacgggtggt cgtcgccgac caccacgcgc actttctccg gctgcggatt
941101 gctcatggcg cgccgaccat ggcgatgagt ttagctgctc gtcggcaacc agccgctggc
941161 agtcgctgga cattgatttg cactccgacg tgcccagcta cggcaacctc ggacgtttgg
941221 gcggtcgcca tgagtacggt gtcctagtgg caatgaccag ctcggcggaa ctggaccggg
941281 ttcgttgggc gcaccagttg cgctcctacc gaattgcttc ggtattgcgg atcggtgtcg
941341 tggggctcat ggtcgccgcg atggtcgttg gaaccagccg gtccgaatgg ccacagcaaa
941401 tcgtgttgat cggcgtctac gcggtcgctg cattgtgggc tctgctgtta gcgtattcgg
941461 cgtcccggcg attcttcgct ttgcgacgct ttcgcagtat gggccggttg gagccatttg
941521 ctttcaccgc cgtcgacgtt ttgatattga cgggctttca gctgctgtcc accgacggga
941581 tctatccgct gctgatcatg atcctgctgc cggtcctggt gggccttgac gtgtcgacgc
941641 gacgggcggc ggtggtgctg gcctgtacgc tagtcggatt cgcagtcgcg gtgctgggag
941701 accccgtgat gctgcgcgcg attggatggc ccgagacaat atttcggttc gcgctctatg
941761 cgttcctgtg cgccacggcc ttgatggtgg ttcgcatcga ggagcggcat acccgttcgg
941821 ttgccggcct gagtgcgttg cgggcggaac tgcttgccca gacgatgacg gcctcggagg
941881 tgctgcagcg gcggattgcg gaagccattc acgatggacc gctgcaagac gtgctggccg
941941 cgcgtcagga gctcatcgag ttggatgccg taacccccgg cgacgagcgc gtcggacgcg
942001 cgttggccgg actgcagagc gcgtcggagc ggctgcggca ggccaccttc gagctgcatc
942061 cggcagtgct tgagcaagtt gggttggggc cggcggtaaa acagttggcg gcctctaccg
942121 ctcagcgttc gggtatcaag atctccaccg atattgatta cccaatacgt agtgggatcg
942181 accccatcgt tttcggtgtg gttcgcgaac tgctgtccaa cgtcgtgcgg cattccggag
942241 ctaccaccgc ctcggtcagg ctcggaatca ccgacgaaaa atgcgttttg gatgtggccg
942301 acgatggcgt gggggtcacc ggtgacacta tggcgcgccg cctgggtgag ggacacatcg
942361 gtctggcttc gcatcgggct cgggtggatg ccgccggcgg agttttggtt ttcctggcca
942421 cccccagggg gacccatgtc tgcgtggaac taccactgaa acggtgaatg gccgttgttg
942481 ccggtcaacc gatgtgccgg tggcagcgac gtgacccccg cgcaggtcga aagccttgct
942541 ggatcgatgg ttccgccggt gcccgccatg ggcccggccg gtcacgccgg ccagtccgca
942601 accggctgtc cagggccatc tcacgggcaa cgtcctggga ggcgctggca gcggcccggt
942661 tcagcccaca agccgcctgt cacagaatgt agtccaggcg ggtcgccatt ccggcgacct
942721 ggtgatagtt gttgtggcag tgcatcaccc acacgccagg attgtcggcg accaggacgg
942781 cgcgcatctt ctgcttgggc agcactatca cggtgtcctt gcgggcgccg gggctgccgt
942841 cggccttgat catctgaaag gtatggccgt gtaggtggat tgggtgatac atcatggtgg
942901 tgttatcgaa catcagggtt ggccgttggc ctagccgcac gtgcagtgga ttggtcgtgc
942961 tgtagggttc cccgttgatt gtccagtcgt acttggccat ggtgccgccc aaggtgaccg
943021 ggaggtcgtg ggtgggttcg ggccggccca ggttggcagt cgttgcggcg gtgaacattt
943081 ccacggtacc cactcgccag ttgagttcat ccggccgaaa ctgcgggtcg ggtgggctgc
943141 cggcgccggt agacagcagc gcacgcgcca gcgcgttctt gccttccgcg agtgcgacca
943201 ggggaaagac gccgccagcg gcggtcacca tgacgtcgta gcgttcggcc atgccgatca
943261 gcagagcgtc gacttcggtg ggaatcactg ggtaaccgtc ggtgtgggtg accgtcatcg
943321 aatgcccggc cagcgcgatg cggaacgcgg tgtcggcggc gctgttgatg atgcggatcc
943381 ggattcgctg gccaggcttg gccttaaaag acgtggccgc cacggggatt cgcccgttga
943441 tcagatagta cgggtaggcg atgtcccctc cgtcgccgcc gagcaggttg ctgtcaacgc
943501 cttcgccttc gggcatacct gttgtgtttt gcatggtggg tttgttcggg tcggtcagct
943561 cgccgtagag ctgttgcggg gacttcccga tgccgtccgt ccaatcgtcg aggatgatga
943621 tccattcggc gtcgtagtgg cctggctcag tcggatcgtc gacgacgaca ggcagatata
943681 ggccgtggtc gccttgaaga ccgacgtgcg gatgggccca gtaggtgccc ggatccggca
943741 cggagaaccg gtacgtaaag tcaccgccgg ggccgatgtt cgcagtcgcg ggctcggtgc
943801 catccatatc gttgcgcagc gcgatgccgt gccaatgcac cgacgtcgga tcacccagac
943861 ggttggtcac cgagacgaca atctcatccc cgacggtggc ccggatcagt ggtccgggga
943921 tggtgttgcc gtaggtcagc gtgctgacga tcggcccacc caggtcgatc ctcgccggct
943981 ggggggtcag cgtggcggta accgttcgcc cactgtgcgg ccgggccgcc tcggccgcgt
944041 cgattgcagc ggtcatcccg gcggcgccgg atgccgtggg cttcgaggcg caagcggcta
944101 gcgcaaagcc gctggcgatg ccggcgccga ggaagccgcg ccggctgaac cgcctcttgt
944161 cgaaggcgtt accgctcgtg gccagctcgg gcatcgatcg ctcctcgtct ggatttggtc
944221 tcgctcttcg taccctgccc agacatcggg cagtacgcaa cggttgatga tcaccacgcc
944281 atcatccgcc cttacaccct acccctatag ggtatatagt gggccacgtg gaaagcgggc
944341 acgtggtgtg gatgcgatcg gcgattgtcg cggtcgcgct gggggtgacg gtagccgccg
944401 tcgccgctgc atgctggctc ccccagctcc accgtcatgt ggctcaccca aaccacccgt
944461 tgacgacgtc cgtaggtagc gaattcgtca tcaacaccga ccacgggcac ctggtggaca
944521 actcgatgcc accgtgcccg gaacggctcg cgacggcggt gctgccgcgc tccgccactc
944581 cggtgttact accagacgtc gtggcggctg cgcccggcat gacagccgcg cttaccgacc
944641 ccgtcgcgcc ggccgcgcgc ggtccgccgg cggcgcaggg atccgttcgc accggtcaag
944701 acctgttgac ccggttctgc ctggctcgtc gctgaggggt cagcgccagg cggtggtggc
944761 cattcgccat cgccggtgac cgctgacccc catccagtgc cgcgtgtgac ttccggcccc
944821 gatgcagaag cgacgatcac tatgaacaac aacctgccgc tggcaaatcc ggtaaaccca
944881 acaagcatca cctccaaccc gcagatactc ctggccaacc gggcgcaccg caccttggtg
944941 aggtcgcggc agacccgcga ccggtaccgc ctcctcccgg agggatatca agtcactcct
945001 ggccggaatc gccacccggg caccatggtt ggcaataccc cggtgctttg gatacctgag
945061 ctgtcgggga cctcagaccc tgaccgtgga ttttgggcca agctagaagg attcaatccc
945121 gggggtatga aagaccgccc cgcgctgtac atggtcgaat gcgcgcgcgc ccggggcgat
945181 atcgcgcccg gtgccgcgat agtcgaatca accggtggca ctctgggatt gggcctagcc
945241 ctcgctggta aggtgtaccg gcacccggtc accctggtca ccgacccggg gctggaaccc
945301 atcatcgcgc gcatgctgac cgcctacggc gccggcgtcg atatggtgac gcagccgcac
945361 ccggtcggcg gatggcaaca ggcgcgcaag gaccgggttg cgcagctgat ggccgaatac
945421 cccggcgcgt ggaatccgaa ccagtacggc aaccccgaca acgtcggcgc ctaccggtcg
945481 ttggcgctgg agctggtcgc tcagcttggc cggatcgatg tcctggtgtg ctcggtgggg
945541 acgggtggac attcagcagg tgtcgcccga gtgctacggg agttcaaccc ggacatgcgg
945601 ttgatcggcg tggacaccat cgggtccacg atctttgggc agcccgcgtc gaacaggctg
945661 atgcgcgggc tgggctcgag tatttatccg cgcaatgtcg attaccgtgc attcgacgaa
945721 gtgcactggg ttgctccccc cgaagccgtc tgggcgtgcc gctccctggc cgcaacccac
945781 tacgccagcg gcggctggag cgtcggggcg gtcgccctgg tagccggctg ggcagcacgc
945841 aacttgccgg cggacaccac gattgccgcg gtctttcccg acggcccaca acgctacttc
945901 gacaccatct acaacgacgc gtactgcaac gaacacgaac tgctaggcgg acaacctccc
945961 accgagcccg acgagattgc ctcgccgcta gacgccgtcg tcacccgatg gacacgcagc
946021 accacggtga tcgatccaac ccaggtggtg tcgtaatggg agcgcgcgct atattccgcg
946081 ggttcaaccg cccgagccgg gtgttgatga tcaaccagtt cggcatcaac atcggcttct
946141 acatgctgat gccgtacctg gccgactacc tagccgggcc actggggcta gccgcgtggg
946201 cggtgggtct ggtgatgggc gtgcgcaatt tctcccagca gggcatgttc ttcgtgggtg
946261 gcacgctggc cgatcggttc ggctacaagc cactgatcat cgccggatgt ctgatccgca
946321 ccggcgggtt tgccttgctg gtggtcgccc agtcgctgcc cagtgtgctg atcgccgcgg
946381 ctgccacggg ctttgccggc gcgctgttca atcccgcggt gcgcggctat ctcgcggccg
946441 aagccgggga acgcaagatc gaagcgttcg cgatgttcaa cgtcttctac cagtcgggga
946501 tcctgctcgg cccgctggtt ggattagtat tgctggcgct ggatttccgg atcacggtgc
946561 tggccgccgc cggtgtgttc ggcctactca ccgtcgcgca gctggtcgca ctgccccaac
946621 accgggccga ctcggagcgc gaaaaaacat cgatcctgca ggactggcgg gtcgtcgttc
946681 gcaaccgtcc gtttctgacg ttagccgccg ccatgaccgg atgctatgcg ctgtcgttcc
946741 agatctatct ggctctgccc atgcaggcgt cgatcctcat gccacgcaac caatatctct
946801 tgattgcggc gatgttcgcg gtatcgggtc tggtcgccgt cggcgggcag ctgcgcatca
946861 cccgctggtt cgccgtcaga tggggggccg agcgcagcct ggtagtcggc gcgacgattt
946921 tggcggcctc gttcatcccg gttgcagtca tcccaaacgg ccagcggttc ggcgtcgccg
946981 ttgcggtcat ggcattggtg ctgtcggcga gtctgctggc ggttgcctcg gcagcgttgt
947041 ttcctttcga aatgcgtgcc gtggtcgcac tgtcgggcga ccggctggtg gcgacccact
947101 acgggttcta cagcaccatc gtgggcgtcg gagtcctcgt cggaaatctg gcgatcggat
947161 cgctcatgag cgccgcgcgc cgcttaaata ccgatgaaat tgtttggggc ggattgattc
947221 tggtgggcat cgttgcggtg gccgggctcc gtcggttgga cacattcacc tcgggttccc
947281 agaacatgac cggtcggtgg gctgcacccc ggtgacccgc gatccacaca gcccggactg
947341 cgggcgcgag ggcagctacc gcgacaccat cacccgcccg ttgaccgacc taccggtggc
947401 cggctatccg ttggtgccgc gggtcgcgtc gccccgctac cggtgcacaa cgccgcagtg
947461 cgggcgtgcg gtattcaatc aggatctcgc taacgtcgac cagtacctcg ttgtcaatca
947521 actggcgcac caactcatcg acggttcttc cctcataccc gatgctgaca agagatggga
947581 tgcgcgacga catgccgaca tgacgcacca tctgacatcg agccttaagg aaaatcaaag
947641 ctaatgccgc cacccctcgg cggcctgttc gtcgaaggtg cggtcaatgc gctcgaacct
947701 gcggcggatc gaagcgcgcg aggccgcatg cggaaggacg tagaggcggt tggccagaat
947761 cgcatcggct gttagctggg cgatatcgtc gacgcccagg ttgtcgtcct gcagggggag
947821 tggaccgggc gatcccgtcg ttgaggactg cgcgcaagcc gcgcctcgga ttcgttcaga
947881 gttggcaacc agattggttt cgacgaccat cgggcagagc accgacaccc caatgccgtc
947941 ggcggtgacc tcgcgggcca gcgtctccgc cagaccgaca accccgtact tggcaacgcc
948001 gtatgcgccg agtccggcat tgggcaccag cccggcaaag gacgcggtga acaccacatg
948061 cccgcccgtg ccctgctcaa gcaacctcgg caggaacgct tcgaccgtat ggatcgagcc
948121 ccacaggtcg acgtcgatca cccaacgcca gtcgtcgtgc gtcatctcca cgatcggacc
948181 gccgacaacg atgccggcgt tgctgaatac gacatcgacg tggccgagca ggcggaaagc
948241 ctcgtccgcg aggtgagtga cctcttctcg atgccggacg tcgcacatca cgctgtgcac
948301 atcgaacccc tcggcacgca ggtggttcac cgcctgccga agtcccggct tgtcaacgtc
948361 ccctagcacg actctggctc cgcggcgggc gaactcggtg ccggtagcca acccgatgcc
948421 actggcaccg ccagtgatga ccgcaccgcg cccgggaaac ccgtccacag cacgcaaccc
948481 tatttcaggc agtcacccgc gtcgactgcg ccgggcgagc gtgattctgg cgacgccaca
948541 gcggcatgtt gcgtcgcggt gttcacaatc ggttacagct gcgctagtcg cggcgcagat
948601 tcatggttga tccgcaggtg cagtgtcgtg caaggttgtc tcgacgatcc aggtgccact
948661 gtggaggcaa tcgatgacga cggatggccg cacaccggcg atccttgcag cccgaattcg
948721 gcggcctccg gcaaatatgg tgaaagacca gcttcggtga gtaccggcga cattcattcg
948781 ttggtgatcg cttcggacta tcgggtccct gatcccggta gagtgtggcc gctgctgcag
948841 cgcaacaaat cggctctggc cgacatcggc gcacaccacg ttctgatcta cgcgtcaacg
948901 cacgactctg gccgtgtgct ggtaatgatc ggagtacgca gtcgtgagcc gatcgtggaa
948961 ttgctccgct cacgggtctt cttcgactgg ttcgacgcca tgggcgtcga cgatatcccg
949021 gcggtcttcg ccggcgagat cgtcgaccga tttgtcgcgg cgcctactac gactcagtcc
949081 actccacggg ttcctggcgt tgtggtggcc gcgttcgcgt cggtgaacaa cgtgtccaac
949141 ctgaccgccg aggtccgttc tgcgatagcc aggtttaccg ccgcggggat tcgaaagacc
949201 tgggttttcc aggctttcga cgatgcgcac gaggttttga tcctgcagga gtttgccgat
949261 gaggcgggcg cgcggcagtg gatcgagcat cccgacgccg ccgccgaatg gatgagcggg
949321 gcgggagtgg gagcctaccc accgctgttc gtcggccggt tcttcgacat gatgcggatc
949381 gaggcgctgc agtgagcgca tcgctgggca ctcggcccgg cccgggtcag cgacctcact
949441 gcggcgccat ggatcccacg agttggccaa gcaggcgggg gatctcgagc cgcggcaaca
949501 ccacctcgac gagcaccatc cggtcccgcc gtgctgcggc gacggtgagg gcgtcgtcga
949561 gttggccata ggtttgggca cggaacgcga ggtgattggt cacacccagc gcgctgggaa
949621 gctcggtcca attccagctc acgatgtcgt tgtacggggc cgtctcgccg tggatggccc
949681 gttcgaccgt gtaaccatcg ttgttgacca ccacgatgac cggggacagc ccttcgcggg
949741 agaacgtgcc gagttcctgc acggtcaatt gtgcggcccc gtcgccgatc aacagcaccg
949801 tacggcggtc cggatgcgca accgcggccc cgactgccgc gggcagcgtg taaccgattg
949861 agccccacaa gggttggccg ataaaggtca ctccttgcgg caaccggtgg tccgccatgc
949921 cgtagaacga cgtcccctgg tcggcgagca ccacgtttcc gggtgtgagc gctgagcaaa
949981 cccggtccca caccatctgc tgggtgagcg gctcatcgcg cgccggcatc gccggcggcg
950041 gttcggcggg cggcggtacc accggcggcg aactgattcc gcgcccggtc aggatggtgg
950101 ccagcgcctg cagcgcggca ctcatttcca gtggtgcgaa cacctggtcg gccacgctgc
950161 tctggtattg cccgatgtcg atggtccggg ccgggtcgat ccgctggctg aagaagccgc
950221 tgaccatgtc ggtgaacacc actccggcgg tcaccagcac cggcgcccct tcgatcgcgg
950281 cgcgcacccg ttcggcgctg gccgcgccgg cgtagattcc caggaagttc ggcgagctct
950341 cgtcgagcag gctcttcccc cacatcaacg tggcgtgcgg caccacgtcg gcggccaaca
950401 gcgcctcgag ttctttgacg gcctgcaggc gatgaaccaa cagatcggcg agcaccgtca
950461 actggtggtc ggcaatgagt tcgatggcgg ccttggtgaa cagcgacagc gcgcgcgggc
950521 tggtgccgcc ggggtagcgg ggcaacggcg cagcgggcgg ttcagtgggg aagcgtgcta
950581 cgtcgctgga cagcaatata tatcctggac gcttctgctc ccgtacctcg gacagcaccc
950641 gatctatttc tctaccggcc gttgccggca tgagattggc ttgggcacag gtgatttcac
950701 ggctgatccg gagaaagtgc tcgaagtcgc cgtcgccgag ggaatgatgc aatgcccggc
950761 gagtgccctg ggcgtctttg gtcgggccgc caacaatgtg caccactggc acatgctcgg
950821 cgtaactgcc cgcgatcgca ttggtcaccg agagctcgcc gaccccgaat gtcgttacca
950881 ccgctgacat cccacgcagc cgcccgtacc cgtcggcggc atacccggca ttcagttcgt
950941 tggcgctgcc cacccaccgg atggtcgggt gggccacgat gtggtcgagg aattgcaggt
951001 tgtagtcgcc gggaacgccg aagatctcag agacgccgag ttcggcgagc cggtcgagta
951061 ggtagtcgcc gacggtgtag acgggatcgc tgcaggcatc gctcttctgg ggtgtcacga
951121 agacgaccgt acgccggatt gcggctattc ccgactggac gccgattcgc tatcgtgcgg
951181 ccatggccat caaggagtcg cgcgacatag ttatcgaagc aagtcccgag gagatcctgg
951241 atgtcattgc cgacttcgaa gcgatgaccg aatggtcgcc agcccatcag agcgtcgaaa
951301 tactcgagac cggagacgac gggcggccca gcaaggtgaa gatgaaagtc aagaccgccg
951361 gcatcaccga cgagcaggtg gtggcctata gctggaccga cagatcagtg cggtggacgc
951421 tggtcagctc cacccagcag cgctcgcagg atggaaagta cgagttgaca cccaagggcg
951481 acaacaccct ggtccagttt gagatcaccg tcgacccgca ggtgccactg cccggcttcg
951541 tgctgaaacg tgcgatcaaa gggacgatcg acacggccac cgaggcgttg cgcagccagg
951601 tgttgaaagt gaagaagggt caatagtcgc ggtgacgacc ggggggcccc tggccggggt
951661 gaaggtcatc gaactcggtg gtatcggacc ggggccgcac gccgggatgg tgctcgccga
951721 cctgggtgct gacgtggtgc gggtgcgccg cccgggtggc ctgacgatgc cgtccgaaga
951781 ccgcgacctg ctgcaccgtg ggaagcggat cgtcgacctg gacgtcaaaa cgcaaccgca
951841 ggcgatgctg gagctggccg ccaaggccga tgtgctgctg gactgtttcc ggcccggcac
951901 ttgcgagcgc ctcggcatcg gacccgacga ctgtgcgtcg gtcaatccgc gactgatctt
951961 cgcccgcatt accggttggg gacaggatgg cccgttggcc tcgacggcgg gtcacgacat
952021 caactacctg tcgcagaccg gtgcgctggc ggcgtttggc tacgccgacc ggcctccgat
952081 gccgccgcta aacctggttg ccgacttcgg cggcggctcg atgctggtgc tgctgggcat
952141 tgtggtggcc ctctacgaac gggaacgttc gggtgtgggt caggtcgtcg atgctgcgat
952201 ggtcgacggg gttagcgtgt tggcgcagat gatgtggacc atgaagggga ttggcagcct
952261 gcgcgaccag cgcgaatctt tcctgctcga cggcggcgcc ccgttctacc gctgctacga
952321 aacgtccgac ggcaagtaca tggccgttgg ggcaatcgag ccgcagttct tcgcggcgtt
952381 gctgagcggg ctcggcttgt cggccgctga cgtgccgact cagctcgatg tggccggcta
952441 cccgcagatg tatgacatct tcgccgagcg atttgccagc cgaacccgcg acgagtggac
952501 gcgggttttc gccggcactg acgcatgtgt tacgccggtg ctggcgtgga gcgaagccgc
952561 caacaacgat catttgaagg cacgatcgac ggtgatcacc gcccatggtg tccagcaggc
952621 cgcgcccgct ccccgatttt cccggacacc ggccgggccg gtcaggccgc cgccggccgc
952681 agccacaccg atcgacgaaa tcaactggta accacggtgg ctgccgaaca ccgcccacca
952741 acggcgcggc gttgctagcg tgaacgtcag tggccgtaaa agcatcgcgg gaatttgtca
952801 tcgacgcgcc ttccagaagt ggtgatggag gcgctggcag atgtcggcgt cctggcttcg
952861 tggtcaccgc tgcacaaaca ggtggaagtg atcgactact acccggatgg ccggccgcac
952921 catgtgaggg caaccgtcaa gattctgggg ctcgtcgaca aagaggtcct cgaatatcac
952981 tggggcccgg actgggtgtg ctgggatgcc gatcagacct tccagcaaca tggacagcac
953041 atcgagtaca ccgtgaaacc tgagggtgtc gatagggccc gggtgcgctt cgacatcacc
953101 gtcgagccgg cgggaccgat ccccggcttc atcgtcaagc gggcaagtga gcatgtgttg
953161 gatgccgcgg cgaaagggct gcagaagttg atcgcgggtg ccggcgatca aggaaacgcg
953221 aaatcgtgac gatgtgacgg gtccgcgtag cggatcgtga ttgctaattt ggtagcagtg
953281 gctatccgag catcgcgcga agtcgtcatc gaagcgcctc cggaagtgat cgtggaggcg
953341 ctcgccgaca tggacgctgt gccgtcttgg tcttcagtgc acaaacgggt cgaagtcgtc
953401 gacacttact ccgacggtcg accacatcac gtgaaggtca ccatcaaggt ggcgggcatc
953461 gtcgacacgg agttactgga gtatcactgg ggacccgact gggtggtgtg ggatgccgcc
953521 aagaccgcgc agcaacacgg ccagcacggc gagtacaacc tgcgccgtga ggataacgac
953581 aagacccgag tgcgattcac cctcacggtc gaaccctcgg cgcccctgcc ggcgttttgg
953641 gtcaacattg cccgcaagaa gatcctccat gcggcgacgg aaggactgcg aaagcaggtg
953701 gtggggcgcc gacggttcac gtcgggctag gtagcgggtc gctcggcgag cacgctcagt
953761 cgcctgattg cctcgtcgag ggtgtcgtct cgtttgcaga aggtgaagcg caccaggtgg
953821 ttccacacat cggcttgttg tgaggcctgt cctgcggcgg ggtcgcagaa cgccgacatc
953881 gggatggcgg ccaccccgac tttctccggt agcgccgcac agaattcggt gctgtcgtca
953941 taacccaacg ggcgcgggtc ggcgcatagg aagtacgtgc cgtagctgtc gtgcactgcg
954001 aagccgatct ccgtcaggcc cgctgccagc cggtcgcgcc gggcccgcaa cgagttccga
954061 agggccgcca cccaggcgtc ttcggtgtct agcgcgaggg cgaccgcagg ctgaaacggt
954121 gcgccgccca catagctcag gtactgtttt gcggcgcgca ccccggcgat gagttcggct
954181 gggccgcaag cccatccgat tttccagccg gtgcagttga acatcttggc cgcactggaa
954241 atggtgatcg tgcgctcggc catgccgtcg aaacccgcca gcggcaggtg tctggcgtgg
954301 tcaaacacta ggtgctcgta cacctcgtcg gtgatcacca caaggttcgc cgccaccgcg
954361 atctcggcga tggctgcgag ttccgtcgcg ctcagcaccg caccggtcgg attgtgcggc
954421 gagttaatga tcagcgcccg agttcgcggg gtcaccgcgc gtcgcagcgc gtcggcgtct
954481 agggcgaagc cgcggccatc gggcaccagc ggtacggtca cgcggtgggc gccggccatc
954541 gccaccaccg gcgagtagga gtcgtagaac ggctcgatca gcaacacctc cgagcccggt
954601 tcgaccagtc cgagcaccgc tgcggcgatg gcctcggtgg ctccgaccgt gaccagcacc
954661 tcggtctcgg ggtcgtagtc gacgccgaaa tggcgccgcc gctgggcggc gatggcccgc
954721 cgtagcggag cgcttccagg gccgggcggg tactggttga cgccgccggc gatggcgtct
954781 tgggcggcct gcagcatctt cggcgggccg tcctcgtcgg gaaagccctg tcccaggttg
954841 accgcgccga tacgggtggc cagcgcggac atttcggcga acaccgtggt cgcatacggc
954901 cgcagccgcg acaccgtcat ggcggtcgag cctatccggg cgacgatgcg cgccgcagcg
954961 ataccttgcc caaccaacag gttggccggg ggccctgtta gggtgccggt acgggaccta
955021 gtcttgaaga aggatccaaa cccccttttg tggaatttgt ggaacaggaa atcgacatgt
955081 ccgaagaagc cttcatctac gaggccatcc gcaccccgcg cggcaaacaa aagaacggat
955141 cgttgcacga agtcaagcca ttgagcctgg tcgtcggcct gatcgacgag ctgcgcaagc
955201 gccatcccga cctcgacgag aacctgatca gcgacgtcat cttgggctgc gtctcaccgg
955261 tgggcgacca gggcggcgac atcgcccgcg ccgcagtgct ggcatcgggc atgccggtca
955321 cctccggcgg tgtgcagctc aaccggttct gcgcgtccgg cctggaggcc gtcaacaccg
955381 ccgcgcagaa ggtgcgttcg ggctgggatg acctggtgct ggccggcggc gtggagtcga
955441 tgagccgggt gccgatgggc tccgacggcg gcgctatggg cctggacccg gcgaccaact
955501 acgacgtcat gttcgtcccg cagagcatcg gcgccgacct gatcgccacc atcgagggct
955561 tctcccgcga agacgtcgac gcctacgcgc tacgcagcca gcaaaaggcc gccgaggcgt
955621 ggtcgggcgg ctacttcgcc aagtcggtgg tgccggtgcg cgaccagaac ggcctgctga
955681 tcctcgatca tgacgaacac atgcggccgg acaccaccaa ggagggtctg gccaagctga
955741 agccggcctt cgaaggcctg gccgcgctgg gcggtttcga cgacgtggcg ctgcagaagt
955801 accactgggt ggaaaagatc aaccacgtac acaccggcgg caacagctcg gggatcgtcg
955861 acggtgccgc gctggtgatg atcggttccg cggccgccgg caagttgcag ggcctgactc
955921 cgcgggcgcg catcgtcgcc accgccacca gcggcgccga cccggtgatc atgctcaccg
955981 gccccacccc ggccacccgc aaggtgctcg accgcgccgg gctgaccgtc gacgacatcg
956041 acctgttcga gctcaacgag gcgttcgcgt cggtggtgct gaagttccag aaggacctca
956101 acattcccga cgagaagctc aacgtcaacg gtggcgccat cgcgatgggc cacccgctgg
956161 gtgccaccgg cgcgatgatc ctgggcacca tggtcgacga actggagcgc cgcaacgccc
956221 gacgtgcact catcacgctg tgcatcgggg gcggcatggg tgtcgcgacg atcatcgaga
956281 gggtttaaca gcatgccaga caacacaatc cagtgggaca aggatgccga cggcatcgtc
956341 acgctgacca tggacgatcc ctccgggtca accaacgtga tgaacgaggc ctacatcgag
956401 tcgatgggca aggccgtcga tcgccttgtc gccgaaaagg attcgatcac cggagtggta
956461 gtcgccagcg cgaagaaaac cttcttcgcc ggcggcgacg tcaagacgat gatccaggcc
956521 aggcccgagg acgccggcga tgtattcaac accgtcgaga ccatcaagcg gcagctgcgc
956581 accttggaga cattgggtaa gccggtcgtc gcggccatca acggggcggc gttgggcggc
956641 ggcctggaga tcgcgctggc gtgtcatcac cggatcgccg ccgacgtcaa gggcagccag
956701 ctcggtctgc cggaggtgac gctgggtctg ctgccgggtg gcggtggggt gacccgcacg
956761 gtacggatgt tcggcatcca gaacgcgttc gtgagcgtgc tggcgcaagg tacccggttc
956821 aagccggcca aggccaagga gatcggtctg gtcgacgagc tggtggcaac ggtcgaggag
956881 ctggtgcccg ccgccaaggc ttggataaag gaggagctca aggccaaccc cgacggtgcc
956941 ggggtgcagc cgtgggacaa gaagggctac aagatgcccg gcggcacccc gtcgtcgccg
957001 ggtctggcgg cgattttgcc gtcgttcccg tcgaacctgc gcaagcagct caagggtgcc
957061 ccgatgccgg cgccgcgggc catcctggcc gccgcggtcg agggggcaca ggtcgatttc
957121 gacaccgcca gccgcatcga gagccgctac ttcgcgtcgt tggtcaccgg ccaggtcgcc
957181 aagaacatga tgcaggcgtt cttcttcgac ctgcaggcca tcaatgccgg cgggtctcgg
957241 cccgaaggca tcggcaagac cccgatcaag aggatcggtg tgctgggtgc gggcatgatg
957301 ggcgccggca tcgcctacgt ctctgccaag gccggctatg aggtggtact caaagatgtc
957361 agccttgagg ccgccgctaa aggcaagggc tactccgaaa agctggaggc caaggcgctg
957421 gagcggggcc gcaccacaca ggagcgcagc gacgccctgc tggcgcgcat caccccgacc
957481 gccgacgccg ccgatttcaa gggcgttgat ttcgtgatcg aggcggtttt tgaaaaccag
957541 gagctcaagc acaaggtgtt cggcgagatc gaagacatcg tcgagcccaa cgcgatcctg
957601 ggatccaaca cctcgacgct gccgatcacc ggtctggcga ccggcgtcaa gcggcaggaa
957661 gactttatcg ggatccactt cttctcgccg gtcgacaaga tgccgctggt ggagatcatc
957721 aagggcgaga agacttctga cgaggccctg gcccgggtgt tcgactacac cttggccatc
957781 ggcaagaccc cgatcgtggt caacgacagc cgcggctttt tcacctcgcg ggtcatcggc
957841 acgttcgtca acgaggcgct ggcgatgctc ggtgagggtg tcgagccggc ttctatcgag
957901 caggcggggt cgcaggccgg gtatccggcg ccgccgctgc agctgtccga cgagctcaac
957961 ttggagctga tgcacaagat cgccgtcgcc acccgtaagg gtgttgagga cgccggcggc
958021 acgtaccagc cgcatccggc ggaggccgtg gtggagaaga tgatcgagct cggccggtcc
958081 ggccggctga agggcgcggg cttctacgag tacgccgacg gcaagcgatc cgggttgtgg
958141 cccggcttgc gcgagacgtt caagtcgggc tcgtcgcagc cgccgctgca ggacatgatc
958201 gaccgcatgc tgttcgccga ggcgctggaa acccagaagt gcctcgacga gggggtgctg
958261 acgtcgacgg ccgacgccaa catcggctcg atcatgggca tcggcttccc gccgtggaca
958321 ggtggcagtg cccagttcat cgtcggctac tccggcccgg ccggtaccgg taaggcggct
958381 ttcgtggccc gggcccgcga gctggcggcc gcctacggcg accgcttcct gccgccggag
958441 tcgctgctaa gctgagcgcg agcagacgta aaagcccccg cacgctcggc gtgtcggggg
958501 cttttacgtc tgctcgcgca acctaaattg ccgggcccag caggtcgtcg gcgtcgcgga
958561 tgatgtaacc gtagccctgc tcagctaaaa accgctgccg gtgtgcggcg tactcggcat
958621 ccaggctgtc gcgggccacc accgagtaga agatggcacc gcccccgtcg gccttgggtc
958681 gcaatatccg gccgagccgt tgcgcctctt cctggcgtga gccgaatgtt cccgaaacct
958741 gtaccgccac ggcggcttcc ggcaagtcga tggagaagtt agccaccttg gacaccacga
958801 gcgtagcgac ctcgccgcgg cggaaggcgt cgaacagtgc ctcgcgttcg ctggtccttg
958861 tcgacccctg aatcaccgga gcgccgagct cggcgcccag ctcgtcgagc tgatccaagt
958921 acgctccgat gaccagggtc tgctcatccg ggtgcttcgc cagaatcgac ttgaccacag
958981 caattttggt gtgcaccgtc gagcagatcc ggtagcgttc ttcgggttcg gcggtggcgt
959041 acatcatccg ctcgctgtcg gtcatcgtga cccggacttc cacgcactca gctggcgcga
959101 tccagccctg cgcctcaatg tccttccacg gcgcgtcata gcgctttggt ccgataaggg
959161 aaaacacgtc gccctcgcgt ccgtcttcac ggatcaacgt ggcggtcagc cccagccgcc
959221 gtttggactg caggtcagcg gtcatccgga agaccggtgc cggcaacagg tgcacctcgt
959281 catagatgat gagcccccag tcgcggctgt cgaacagttc cagatggcgg tactcgccct
959341 tagtgcggcg ggtgatcatc tggtatgtcg agatggtgac aggtcggatt tccttgcgtt
959401 ctcccgagaa ttcgccgatc tcattctcgg tgagcgaggt gcgcgcgacc agctctcgtt
959461 tccattgccg ggccgcgacg atattggtga ccaggatcaa cgtcgtcgcg ccggctttgg
959521 ccattgcggc cgcaccgacc agcgtcttgc cggccccaca tggcagcacc accaccccgg
959581 agccgcccgc ccagaacgag tccgcggcca gccgctggta atcgcgcagc tgccagccct
959641 cctggtgcag gctgatcggg tgcgcttcac catcgacgta gccggcgaga tcctctgcgg
959701 gccaaccgat cttgagcagc agctgcttga cccggccgcg ttcgctgggg tggacgacga
959761 cggtgtcgtc atcgatgcgg gcgccaagca tcggcgcgat cttcttgttg cgcagcactt
959821 cctcaagcac cgcgcggtcc aggctcacca gcgtcaggcc atgggccggg ttcttgacca
959881 actgcagtcg tccgtagcgg gccatggtgt cgacgatgtc gacgagcaag ggttgcggca
959941 ccgcgtagcg ggagtaactg accagcgcgt cgacgacttg ctcggcatca tggccggcgg
960001 cgcgagcatt ccacagtgcc agcggtgtga tgcggtaggt gtggacatgt tcgggtgcac
960061 gttccagctc ggcgaacggc gcgatggcgg cgcgtgcagc gccggccagt tcatggtcga
960121 cttccaacag caccgtctta tcggactgca ctatcaatgg tccgtcagtc aatggcgccg
960181 ctcctcctca tcgctgcgct ctgcatcgtc gccggcggta gtcaatggcg ccgctcctcc
960241 tcatcgctgc gctctgcatc gtcgccggcg gtagtcaatg gcgccgctcc tcctcatcgc
960301 tgcgctctgc atcgtcgccg gcgcgggggt catgggctcc attatcggtc gtgggccgac
960361 accaccaacg tgatgcggtg gatggcgaag tcacgcagtc gcccggatga cgagtcgaac
960421 gccaccagct ggccgccccg tagcgtgatc ggtgcgacca cccgctgagt ggcaacgccg
960481 gcggcatcga ggtagctgat caccaaggtg gcctggtcct tggccgcgcg ctgcaacagc
960541 gacatggtga ccgccgggtc gacgcggaca ttagcgaacg gcgctgcggt cacctcacgc
960601 agcacggcaa ccacggcttt caacgcctcg ctattgggtc tcggcggcgg tcggtatggc
960661 cggcgccgtt gcggtgtggg cacccgggcg ccgcgggttc gcacgtcgac aacggctccg
960721 gtggaatctt cggcggccgg ggcaaagccc gcgccgcgca acgtgacgag gacttcggat
960781 atcggagcgg gggacaccgc caccgttggg gccagggccc gcagtgccag cccgtcggct
960841 tcgggcgccg ccacgacctg ggccagtagc gttgggtcct cgcaccgcac gaacgatgcg
960901 gccatgccga tccgaagctg gccgtgccgg cgcgcgacat cgtcgatgag atatgtaagc
960961 ccttgtggta caggagtttt agaacgattt gcgaagaatt cctgcaacca gtcgcgggac
961021 ttgccgacat cgagggcatg ccggatcgac tgctcgctga cgcggtacac catcgccgtg
961081 ccggccgatt ccacggtggc gacggtggtc aggtcgtcgg ccagttcgcg ctgcagcggc
961141 cctggcacca cgacggtcag gtcggcctgc accaggaagt gatcgatggg cttgggcagc
961201 gcccgagcca tcacgccgac cgcggcggca ggggcagtag ctggctctaa ggcctcgtcc
961261 aacagtgcgc gagcaggcgt gctgatcgcc ccgcgcccca ccagacccag cgcatggccc
961321 tctgtcagca gatccgcgat aggcgcaggt tgcaatcgcc tggcccaacg tgggcggcgc
961381 cagatcagtg tcgccgacgc ccgggacgca tcgacgccgg cgccggcggg cagctcggcg
961441 agcatgccta gcaatagccg gcgatccagt ggggccgccg tggagaacag cgaatccgac
961501 agggcgccat agggtttggc gtcgggtccg cgggtaccga ttaacgccgg ccggcccgga
961561 aggtcaagcc aggcgctggc cagcaagtgc caacgctcgg cgggtgacat cgtggcgaat
961621 cgatcggcgg ccaccgttgg cgcccaaaaa ggtccgtcac tgtggggcgg ttcgggatcg
961681 ggcatgccgc tggcgatcag tccagccgcg gccgcaatct cgaggattag gcccagccgc
961741 ggctcgtcga ttcccgttgc cttggccagc cgcttgaatt cacgaacccc cagtccgccg
961801 ctgcgtagtt cggcaaccgg tgtggcgccg aggttttcga gcagtacgtc gacttcacgc
961861 agtaggtcga tgacggctcc ggccgccgca gcgtcggcgt cgtcgggtgt ggtggtggaa
961921 actaccgggt ccggcgcggt caactccatc ggaccgggtt gttcgccgcg cagcacctgc
961981 ccgacgtggc ggggcaagat caccgtttcg gcatcgattc gtcgcagcaa gcccatcgcc
962041 agcaaccgcg gcacgggtcg atcagatggc gcgccgggtg cggcgtcgcg agtgcgcccc
962101 acgggtgacc cttggagcaa tttgtccaga acgtcacgct gcgcggggtc gaggccggcg
962161 atcaggtcgg cgagctgatc cccggaacgc gaacttccct cgagggtgac ctggccggga
962221 tgccacggca acgccgtacc tgcgtctgtc gccacccgga ctgcggtctc gccccaggcc
962281 agggcacgtt gtttaaggtc agccagcgcg ccaagcacgt cggcttgggc ggcgcggtcg
962341 ccgatcactg ccagcagccg gacgatcggc accggtgcgg tatctgcctg cagcaccagc
962401 agtgcgtcga acaccgccag ccgcaggaag tcgagctcgt cggtggccgc cttgaccgac
962461 tggcgggcct gggcacgggc ggccagcgcg gcgatgctgc cgggtggtgg ctgggcaagg
962521 tcgggccgca gctccaacag ctgggtcagc cgttcatcgg gcaaggcggc cagccaggac
962581 cccagcggga tatccggggt gtgttcggtc attgctgatc agcgtaggcc ggaccagcct
962641 tgtggcgtgg gcgggtgcaa gacctgtcag aatggtttcg tggctgacat tgctgaaggt
962701 aaggcacgca agaccaggta cgtggaccat ggttggccga ccaccgatcc agacgaccat
962761 gcggtgagcg aactcgtgac cgaccgcacg ggtgcgctat cacccttcgg tgaattgacg
962821 ttcccggtac cgtccgacga cctgccctac atccacccgg tgaccgtcat caatcggtaa
962881 gccgccagga tggccagggc ttctggggca tccgactacc gctcgggcga gctgtcgcac
962941 caggatgagc ggggggcagc gcacatggtc gatatcaccg agaaggcaac cacgaagcga
963001 acagccgttg ccgcgggcat cttacgtacc tcggcgcagg tggtggcgct gatctcgact
963061 ggcgggctgc ccaaagggga tgcgctggcc accgcgcggg tggcgggcat tatggcggcc
963121 aagcgcacca gcgacctgat cccgctgtgc catcaactcg cgcttaccgg agtcgacgtc
963181 gatttcaccg tcggccagtt ggatatcgag atcacagcga cggtacgcag taccgaccga
963241 acgggcgtcg agatggaagc gctgaccgct gtcagcgtgg ccgccctcac gctctacgac
963301 atgatcaagg cggtcgatcc gggcgcgctt atcgatgaca tccgggtgct ccacaaagaa
963361 ggcggtcgtc gcgggacctg gacgaggcga tgagcacccg gtccgctcga attgtcgttg
963421 tgtcgagccg cgcggcggcc ggtgtgtata ccgatgattg cgggccgatt atcgctggat
963481 ggcttgaaca gcatgggttt tcgtccgtcc agccgcaggt ggttgccgac gggaacccag
963541 tcggcgaggc gctacacgac gcggtcaacg ccggagtcga cgtgatcatc acttccggcg
963601 gcaccggtat ctcgcccacc gataccacgc ccgaacacac ggtcgccgtg ctggactacg
963661 tcattcccgg gctggccgac gcgatccgcc gctccggcct gcccaaggtg ccgacatcgg
963721 tgctgtcgcg cggggtgtgc ggcgtggctg ggcggaccct gatcatcaat ctgccgggat
963781 cgcctggagg tgtacgtgac ggcctcgggg tgctcgccga tgtgctggac catgctctcg
963841 agcagatcgc cggtggagat cacccgcgat gacgcaggtc ctgcgcgccg cgctgacaga
963901 tcaaccgatc tttctggccg agcacgagga gctggtgagc catcggtcgg ctggcgccat
963961 tgtcgggttc gtcggaatga tccgcgaccg tgacggtgga cggggggtgt tgcggctgga
964021 gtactccgcg cacccgtcgg ccgcacaggt ccttgcggat ttggtggcgg aggtagctga
964081 agagtccagt ggcgtgcgtg cggtggcggc cagccaccgg atcggcgtct tgcaggtcgg
964141 ggaggccgcc ctggtggcgg cggttgccgc cgatcaccgg cgggcggcgt ttggcacctg
964201 tgcgcacctg gtggagacca tcaaggcgcg gcttcccgtg tggaagcacc agttcttcga
964261 ggacggtacc gacgaatggg tgggttcggt ttaaagtccg gcctcagccc gtcagccgat
964321 gacgtacggc tgtgcgagcg agtccagcgc atcgttgccg cagacgtcct gggcccgaat
964381 cgcctgccac agcttcttcg tataggcgat gttcgagact tggggcgttt cggcgggcgc
964441 ctcggtgacg tcgccgggcg gcggtgcgtc agctggttgg gggtcgggct cggggagttc
964501 caaatcggtg gcaaggccaa ccgggccgcc tggagctgtg gcgggctgat cgcccggcgc
964561 ggtttgctcg ttcaccgcag cgggtggtgc caggtcggcg ggcgcgggtg gcgccagttc
964621 ggcgggcgcg ggtggcgcca ggtcggcggg cgcgggtggc gccaggtcgg cggacgcggg
964681 tgccagatcg gcgggtggcg ccagttcggc gggagctgcc gggaggggtt cacccagcgg
964741 cgcgggcagg tcgtttacgg caagttccac gggtggtgcc aggtcggcgg gcgcgggtgg
964801 cgccaggtcg gcgggcgcgg gtggcgccag gtcggcgggc gcgggtggtg ccaggtcggc
964861 gggtggtgcc gggtcggcgg gagctgccgg gaggggttca cccagcggtg cgggcaggtc
964921 gtttacggca agttccacgg gtggcgcgac gtcggcgggc gcgggtggtg ccaggtcggc
964981 gggtggtgcc gggtcggcgg gagctgccgg gaggggttca cccagcggtg cgggcaggtc
965041 gttagcggca agttccacgg gtggcgccgg gtcggcgggc ggcggggcca gcggtgctgg
965101 ttcgccgttg accgcggccg cgtccaacgg agcgtccatc gctgccgaag cgggaagcac
965161 ttcgcggggt gttgcgttcg ataacccgcg gccgcacacc ggccaggcgc cgcgaccctg
965221 ggtggccagc acccgctcac cgacggcaat ctgctgctcc cggctggcca gctgagccga
965281 cggggcgaac tcgccgccac catgtgcggc ccaggtgctt tgagtgaact gcaagccacc
965341 gaggtaaccg ttgccggtgt tgatcgacca gttgccgccc gactcgcagc gggccacctg
965401 atcccattcc ccgtcggtgg ccgcggtcgc ctgagcggcc atggcgatgc cgccgccacc
965461 gagtactgcg ccggtaaagg cgatcttggc gacgctgacg ttggatgtgg tgggcttacg
965521 gtggcgtcca ctcatacgtt aggtaattcc tctcggtaca cgcctacgag gtcagctgtc
965581 gggttcgggt tggattcgcc gtggagagga tcacccggcc gcggtcgtac atcggcgaac
965641 gacgttggct tcaccccaag gagccgtatg cggctccggt ccgatctcgg cggacctggt
965701 gggtcccccg cctccatccg cggtcggaat ccctcgccca ctggatggag ttcggcgtgc
965761 tatcggcgag ggagggcacg tcattttggg ttaggttgac gagcctcccg agacggtagc
965821 ggtttcaggc gattccgtca cgtttaagaa aagtcggcgt ttccgtcaca atcgccggca
965881 agaacgccaa gaaatatagg catttgcgca ggtagtaagc cctcgcaatc ggagcgtgtc
965941 cgccccgtta tcgttccgtt atgtgggtaa tgtcacatgg ccttagccgc cggcgaaagg
966001 gggtagtacg tcaatcgtgt cgccggcgga taacgcgacg gcgtcatctc ggacgacaat
966061 cccgtcgcgc aggtaggagc atcgactcaa caccgtcgcg aggcgaacat cgcggaccga
966121 caggccgtct atcagctcgg cgactgtggc gccagatcgc agggtgactt tctccgaccc
966181 ggcaccagcg gccgctcggg cggccgcgaa gtagcggaca gtcacctgaa ttccggcgga
966241 ttcgtcggac acctgcgtca ccggttagcc accgatcgcg ctcatcgggc ggtcgggctg
966301 aatgaaatcg ggggcgttga tgccgtggcc ggcgggtttg ctccacatcg cggcacgcca
966361 tgccgcctcg atcgcgtcgt cgtcagcacc gccgcgcagt aggcggcgca ggtcggtctc
966421 ctcggtggag aacagacagc tgcggatctg gccatcggcg gtcagccggg tgcggtcgca
966481 cgtcgaacag aaggcgtgcg acaccgaggc gatgacaccg aaccgtccgc gtggcgtgtt
966541 cggtccggcg tcgaccagcc agagttcggc cggggccgaa ccgcgcggtg ccgggtcggg
966601 ccgtagccgg aagtggggcc gcagcgccgc cagcacgtcg tcggcgctca gtgcgatgtt
966661 ccgccgccag ctatgccccg cgtccagcgg catctgctcg atgactcgca attgataacc
966721 gcgctctagg cagaacctca gcaggtcgac gacatcctcg cggccggtcg tggggtcgag
966781 gacggcgttc accttgacgg gtgtcaaccc ggctgccttg gcggcggcca agccggccag
966841 cacatgcgca agccggtccc gacgggtgat agcagcgaag tgggcgcggt cgatgctatc
966901 cagcgagacg ttgacccggt ccaggcccgc ttcggccagg gcgcccgccc gccgcgccag
966961 tcccaccccg ttggtggtca gcgagatctc cgggcgcggc cgcagcctag ctgtcgctgc
967021 gaccacctcg tcgaggtggt gggccaatag cggctcgccg ccggtgaacc gcacgctggt
967081 gacgccgagc cgagttaccg cgatgtgtat cagcctggcc agttcgtcgg gccgcagcag
967141 ttgctcgccg ggcagccacc tcagccctcg ctcaggcatg cagtagctgc accgcaggtt
967201 gcagcggtcg gttagcgaca cccgcagatc gttggcgacc cggccgaacg tgtccaccaa
967261 agggccagtg gtgggtacga cccgcgggtc ggcaatgccg ttggtgcggc tgcgcagcgc
967321 cggcatgccc agcgcggtca gtgtcatgtg ggcacctgtg agttgacccc gacgatgtcc
967381 ttgcccagcg gcaccagcga caccgggatc agtttcaagt tggccagtgc tagcggaatg
967441 ccgatgatcg tgactgccat tgccgcggca ctcaccaaat gcccgagggc cagccagatc
967501 ccgaacagca gcacccagat gacgttgccg atcaaggccc cggtcccggc ggttggcttt
967561 tcgacgatcg tccggccgaa cggccacaac gcgtacgacg cgatgcgcag cgccgcgaag
967621 ccaaacggaa tggtgatgat gagcaggaag cagacaagcg acgccagcag gtacccgagg
967681 gccagccaga ggccaccgaa caccaaccag ataacgttca ggattagtcg catatcgcct
967741 ccagcggtag cgcaagccta ccgcgtgagg ggtaagcagg ggtgctcggc ggccgacgat
967801 ccgagtagga tcttcagatc gtcatcgcgt cccgcgcagg cgggacgcgt cttctgttgc
967861 caatccgagc gatccgtcag acaagcaggt gagaccagtg ccgaccggca aggtgaagtg
967921 gtacgacccc gacaaggggt tcggcttcct gtcacaggag ggtggcgagg atgtctacgt
967981 ccgctcctcg gcgttgccca cgggtgtcga ggcactcaaa gccgggcagc gggtggaatt
968041 tggcatcgcc tccgggcggc gcggaccgca ggcattgagt ctcagattga tcgaaccgcc
968101 gcccagcctc tcccggccgc gccgtgagcc ggcggccgag cacaagcaca gccccgatga
968161 gctgcacggc atggtcgagg acatgatcac gttgctggaa agcaccgtgc agccggagct
968221 gcgtaagggg cgctacccgg atcgcaagac tgctcgccgg gtcgccgagg ttgtccgggc
968281 ggtggcgcgg gagttcgagt cctaacgggg tcgggtggtg cgctggccca attgcgccga
968341 gctggcaacg ccgcgccgtt ccagggtcac ggtcggatcg attccgccgc actcggtttg
968401 acgagacgac gaccggctag cagttagccg ggttggccgg cgctgcccgg gctgccgccc
968461 atgccgggat tgccgtcggt ggttttcccg tcgccgcccg tgccgccctc accgcctgtg
968521 ccgccggcgc cacccgcgcc gcccgctcct ccggcaccaa cgccaccgtc gctgcccgcg
968581 cggccaatca gcccgccgga cccgcccttg ccgccgaggg cgccgggggc gccgccgttg
968641 ccgccgttgc cgccggtgtt gccgttaccg ccaaacgctg cgcccggacc actgttggtg
968701 ccgccaccac cggcgcctcc ggcacctcca gcaccaccgg aaccaccagt accaccggca
968761 ccggccgtgc cgccgacacc accggcgccg ccgttgccga tgagcagccc gccagcaccc
968821 ccgttaccgc cctggccgcc gataccgcct tcgccaccgg tgccgagggc gctcgcgccg
968881 tcaccgccca caccgccatc gcccccgaac gccttgcgtg aactgccggc gctgtcggtg
968941 ttggcggcac cgccgtcgcc cccggcgccg ccgccgccgc cgggggcacc gctaccaccg
969001 gtaccaccga ctccgcccgc gccgccggcg ccgccgtcgc cgatcagcag cccgccgcgg
969061 ccaccggcgc ccccggttcc gcccgctccg ccggtaccgc cggaagcgaa gctgtcgaag
969121 ccgttgccgc cgctgccgcc gttaccggct tccgcgttgc tgggagaatt ggtgcccacc
969181 tgggcatccc cgccttcgcc gccggcgccc cccacaccgc cgggggcctg ggcgttcccg
969241 ccggcaccgc cgttacctcc tatggctgca ttgccgatgg aagcggcgct gccgccggcg
969301 ccgccagcgc cgccataggc gccctcaccc cctttgcctc cctcaccgcc cacggcgtcg
969361 ccgttgacgg ttgagacggc gttcccgcca gacccgccag cgccgccgga cgtcatcgcg
969421 tcgccggcat cgccggggcc accgttaccg cctatggcgt tgccgcccag cgtctggtcg
969481 gtgccggtac tgccggcatc agcggtgccg gtgggtgtgg ggttgacgcc gtctgccccg
969541 gctgccccca taccgccctg cccgcccgcg ccgccagaac cgaacaggta ggcgttgccg
969601 ccggcacctc ctgctgcgcc cataccgcca ttgacgccgg ccaccccggt ccccccgagc
969661 ccgccggccc cgccattgcc gtataaccac cccccgttgc cgccgacgcc gccgaccgcg
969721 ccggcccctc cggccccccc ggtcccgccg atgccgatca acccggcgct gccgccggct
969781 ccgccggctt ggccgacccc gccggacccg ccattgccgc cgttgccata caacaagcca
969841 cccggcccgc cggcctgccc ggtacccggc gcaccattgg tgccgttgcc gatcaggggg
969901 cgcccgagca gcgtctgcgt gggcgcgttg atcacattca acgcttgctg cagcggggag
969961 gcatttgcgg cctcggcgct accatatgcg cccgcagccg tgctcaaggc ctggataaac
970021 cgttcatgaa acgcggccgc ctgcgtgccg agtgtctgat aggcctgggc gtgcccggaa
970081 aacagcgacg ccaccgctgc cgacacctcg tcggcgcccg cggccagcac tccggtggtc
970141 ggggccagcg ccgcggcatt ggccgcgctc aacgtcgagc cgatctgcgc caaattgttt
970201 gctgccgctg ccaccatctc cggcgtcgcc aatacatacg acatcgctgt cctcccgcag
970261 ggtcttcgtt gaccgatcgg ctgttactaa cgttagcgcg aacgcgggtc ggcgtctcca
970321 gtttctattt cttgacatgg aaaaacggcg gccccgaccc tgcctcagcg tcgcagccgt
970381 cgttggcggc gagcaccggt gaccgtgact ttggtagcgg cccgtccgca gtgggtgcca
970441 cgtagtattc ggacagatag gtagtggtag gcaaccttcg tgattcgtca gcgaggaggc
970501 ggcgatggca cagcaaactc aggtcaccga ggagcaagcg cgggcccttg ccgaggaatc
970561 tcgcgaaagt ggttgggata aaccgtcctt cgccaaagaa ctctttctgg gccgctttcc
970621 cttagggctc atacacccat ttcccaagcc gtcggacgcc gaggaggccc gaaccgaggc
970681 gtttctggtc aaactgcggg aattcctcga caccgtggac ggcagcgtca tcgagcgtgc
970741 tgcccagatc cccgacgagt acgtgaaagg cctggccgag ctgggctgtt tcggcttgaa
970801 gattccgtcc gagtacggcg ggttgaacat gtcgcaagtc gcctacaacc gcgtgctgat
970861 gatggtcacg acggttcatt ccagtcttgg cgcgttgttg tcggcgcatc agtcgatcgg
970921 ggtacctgaa ccgctcaagc ttgccgggac tgcggaacag aagcggcggt tcctaccgcg
970981 gtgtgcggcc ggcgcgatat cggccttttt actaaccgaa cccgatgtgg gctccgatcc
971041 ggcgcgcatg gcatcgacgg cgacgccgat cgatgacggc caggcttacg agcttgaggg
971101 tgtgaagttg tggaccacca acggtgtggt agcggacctg ctagtggtta tggcgcgggt
971161 accgcgcagt gaagggcacc gagggggaat cagcgccttt gtcgtcgagg ctgattcgcc
971221 cgggatcacc gtggagcggc gcaacaagtt catgggactg cgtggcatcg aaaacggcgt
971281 gacccggctt catcgcgtca gggtgcccaa agacaacttg atcggcaggg aaggcgacgg
971341 tctgaagatc gcgctgacca cactcaacgc cggacggctg tccctaccgg cgatcgcaac
971401 cggagttgcg aaacaggcgc tgaagatagc gcgggaatgg tccgtcgagc gagtgcaatg
971461 gggcaagccg gttggccaac atgaagcggt agccagcaag atctcgttca ttgccgccac
971521 caattacgcg ctcgatgcgg tggtcgagct gtccagtcag atggccgacg aaggccgcaa
971581 cgacatccgg atcgaggctg cgctggctaa attgtggtcc agtgagatgg cctgcctggt
971641 tggcgatgag ttgctacaga tccgcggtgg ccgcggatac gagaccgccg aatccctcgc
971701 cgcgcgcggt gagcgggcgg taccagtgga gcagatggtg cgggacctgc ggatcaaccg
971761 gatcttcgaa gggtccagtg agatcatgcg gctgctcatc gcgcgtgaag cggtcgacgc
971821 gcacctcact gccgcgggtg atctggcgaa ccctaaggcc gatctgcggc agaaggccgc
971881 ggcggcggcc ggcgccagcg ggttctacgc gaagtggttg ccgaagctgg ttttcggcga
971941 aggccaacta cccacgacgt accgcgagtt cggcgccctg gcgacacatc tgcgttttgt
972001 cgaacgctcg tcacgcaaat tggcccgcaa caccttctac gggatggcgc gctggcaggc
972061 cagcctggag aaaaagcaag ggttcctcgg ccgcatcgtg gatatcggcg ccgagctatt
972121 cgccatctcc gcggcgtgtg tgcgcgccga ggcgcagcga acggccgatc cggtcgaggg
972181 tgagcaggca tacgaactgg ccgaggcgtt ctgccagcag gccacgttgc gggtggaggc
972241 gctgttcgac gcgttgtggt ccaacaccga cagcatcgac gttcggctgg caaacgatgt
972301 gctggagggc cgctacacct ggctggagca agggatactc gatcagtccg aaggcaccgg
972361 accgtggatc gcgtcctggg aaccgggtcc atccaccgag gccaatctgg ctcggcggtt
972421 cttgacggtg tcgccatcga gcgaagcgaa actttagggc gcccgcgtgg ccggtcacgt
972481 ccgcggggga ccgcccgagt ctcgtcgggt accacgctgg cgcgtatcgc gtctgggtgc
972541 aggttctatt ccatgtcgtc gacaaacagc gccatcgatg cggtgaatcc gtgcagggca
972601 ttgcggcccg cgatcgggcc gatctctccg gcggcgaaga agccggcaag cggaattccg
972661 cctaggagtt cctcgatcgt cgacgcgtcg tggtcggcga ccccgaacat ccgccgcccc
972721 cgcccgttgc aggtgaacaa cagcgctcca gccgcgcgtc cgggcagccg cgccgcggcc
972781 cgctccacgg tcaggcgtag gtccttgtcg gccccggccg cgtcacggac ctggaactgc
972841 atggtggcgc cgacctggac aacctcgtcg atctcgatcg acccggtcga cgggtcggcg
972901 ccgagcagcc cgcggatcac gaaatcgccc tgacccggag ccgccaggtg ctcgtcgacg
972961 acgatcccga tctgtaggcc gtggctgacg agtgcccttt cgtcgggcga cagcccctcg
973021 acgatctcac gcagtcgctg caacggcgga cggccgccga gctcggtgat cagtatgccg
973081 tccgcgccgg tgacgatgta tgggtagccg atcggccggc aaccctgcga cacgaccggg
973141 acaccgcgca tcccgggcag gcgcacgccg acgacgccgg aggtgagcac gtcgtgatcg
973201 cggaacagcc gggtgtcgcc ccgccggcgc ccgccgctca ccacgccgcc cacgacggcg
973261 gtgcccggca ggtcggtgtt ggggtgctcg atgagcaggt tcgacgggaa tgtgtacggg
973321 tccggcagca gcagatgcag atcccgggcg gtgcggtcga accgataacc ggtgatcagg
973381 gcacccgagc cggtacggac aaagtccagc tggaatgtct cggcggccaa gccggacgcc
973441 agccacacca ccaccgcggg ctcgtcctcg atctcgtggc ggccggcgac gatggcctgg
973501 gcgatgcaac cgacaagcgc gggcggatcg atcatctgca gcaccgcgct caggacgtcg
973561 gcagcccggt cggtgtgtgc acgcgatcca agcaacaccg ccagcgacgg cgcctcaccc
973621 gccagctcgt cgcgcgcctg gcccgcagcc tccaccgcgg cctgccgcgc gtcgggcgtg
973681 gtgcaaaccc cgactccgat ccgcacagtt ccatgatgcg ccgatgtgcc ccgggtgtcg
973741 gcggctcttc ggaccgttgg cgccgaccgc gcttaagcgc ggtcggccgt cgagccgcgg
973801 cctcgtcaaa agataaggcg caccgaccat tccgcgtgcg gaacgtcgcg tagttcaccc
973861 gagtggtcga ccaccaacgt cagcaactgc acgacaatcc cggtcagccg cccgcgctgc
973921 gggtcgacag tggggatggt gaccgccaac cgggtgtccg gccgaaacaa ggtgctggtg
973981 gtgttggcgg ggtcctggta tacctgcagc aaacgccacg gcgcccggga aatgacttcg
974041 ggtaccgaga gctgcacggg atagcgttcg cttaccggca attcgccctg cgcctgcggg
974101 gtctgacagt cgtcgaggtc gaccacgttg cagtacaaat agggccccac gcgggtcagg
974161 tgcccgtgcg agtaagcgct gatctcgggt tgctgcggac cgtgtccgcg tactagcagc
974221 catgcaccgg ccccggccgc caccgagagc agaatcacca ggatcaccgg cagcgttgcg
974281 acaccgcgct tcactgcggc gccaccgccg caccacgacg ggtggtttct tgctcggcca
974341 tcacgggccg attaccgccc aggccaggga tcagcgaatc gccgcggaag ctgacgatgg
974401 tctgagccag acccaggatc agcagcgcgc tcaccgcagt gaagcccacc cacagctcgg
974461 tgtacaccaa cacgcccacc gcgccgccca gcacccaggc cagctgaaga gtcgactcgg
974521 aacgcccaaa ccccgatgcc cgcgactcct cgggcaggtc gtgctgcaac gaggcgtcca
974581 gcgaggcttt agcaatggca ctggaccctg ccgtgatcag ggtggcaatc gctgtcgctg
974641 ccaggctgcc ggccaccgcg gccgcgatgg ctaacacggt aactagcacg gtgcagcgca
974701 ccaccagcac agctggcctg cctagctgca ggcgtgcgct ggtgaaattg ccggcgaagt
974761 tgccgaccgc ggccgccgcg ccgatcaggc ccagcatgcc caattgcacc cacccgttgg
974821 cttcgtgcgc cttggcgaca aacgccggat acaagaacag aaagccgacc atcaccttga
974881 tggtgcagtt accccacagg gaggtaatga tgttgcggcc caacggttgt cggagtgttc
974941 cgccgaggtt cttgacttcc tccggccagc gtcgccgtag tctgccccta tcccggtggt
975001 agctcaatgt ggccgggacc tcaccgctgg tcacctcgac ccagcgcgga atgcgcatcg
975061 acagcgaagc gccagcgatg gtgatcgcga cgacgacgaa caacgcgccc ggcagctgga
975121 acaggtgggt gcagacgaat tcgactccgg ccgcaatcgc gccaccagcg atggtgccgc
975181 cgagcaggcc gaacacggtc agccgtgagt tgacccggac caagtcgatg gttggcggca
975241 tcaccctcgg tgtcactgcg ctgcgcagca cgctgaacga cttcgagaac accatcatgg
975301 ccagcgcaca gggatagagc acccatgacg ggaagctgcc ggtggcgccg tcgtagttca
975361 tgatcagcac caccgccaac gcggtccgaa gtccgaatga cagcgccaag gcgacgcgac
975421 ggccatgctg cagccggtcg agtgccggac cgatgagtgg agcgatcacg gcgaacggcg
975481 cgatggtgat caacaggtac aaggcgaccc tggacttgct ctccccgctg gcggccgcaa
975541 agaatagtgt gtttgccagt gctaccgcca ttgccgagtc gaccgcgaag ttcgccatta
975601 ccggccaggt caatgccgtc agtccagact tgtcggcgcc gtctgcggta gcggcccggt
975661 gcaccagcaa gtacatccga gaacccattt cgcggctgcg catggccgcg gcgcgggtga
975721 cggtgatccg ctcgcccgcc cttgtagtcc gtggcggtac gcggctgcgt tcaggttcgg
975781 gctgctcgcc cagcggcggg agatagcggt tggcactggg catcggcgga ggtcgacgcg
975841 atcggcgata gttggcgtcg tcgggagggt agttggccat gccagggtgc ccgttgaccg
975901 atccgtttcg ggtccggcgg cccggggttg gggccatccg gcccggatga tcacctcgcc
975961 gtccggacac aaatcaattc tgtcctatcc ggactcctgg cgtagccaac cgggtgtggc
976021 ttgccggccg tgtcttccgg cagtattgga agcgcgttac agagagggga cagcgtgacc
976081 gggcccaccg aggagtctgc cgtggcgact gtggccgact ggcccgaggg gttagcggcg
976141 gtgctcaggg gtgcggccga ccaagccagg gccgccgttg tggagttcag cggcccggag
976201 gcggtgggag actacctggg cgtcagctac gaggatggca acgccgccac ccaccggttc
976261 atcgcgcatc tgcctggcta ccagggatgg caatgggccg tcgtggtggc gagctattcc
976321 ggtgcggacc atgccacgat cagcgaggtg gtgctggtcc cggggcctac cgcactgctg
976381 gcgccggatt gggtgccgtg ggagcaacgg gtgcggccgg gagacttgag ccccggagat
976441 ctgctggcgc cggcgaagga tgatccgcgg ctggttccgg gttacaccgc cagtggtgat
976501 gcgcaggttg acgagaccgc cgcagagatc gggttgggtc ggcgctgggt gatgagcgcc
976561 tggggtcgcg cccagtcggc ccaacggtgg cacgacggcg actatggtcc cggctctgct
976621 atggcgcggt cgacgaaacg cgtctgccgc gactgcggtt tcttcctgcc gctggccggg
976681 tcgctgggcg caatgttcgg ggtatgtggt aacgaactgt ccgctgacgg gcatgttgtc
976741 gataggcaat acggctgtgg cgcccattcc gacaccactg cgccggccgg tggcagcaca
976801 cccatttatg agccgtacga cgacggtgtg ctcgacatca tcgagaagcc ggctgaatca
976861 taggttttct ctcacccgct gttccctact tttttttggg ggggggcacc agtcgaagaa
976921 acccgactga ttatcacccg tattgaacac tcccgagctg ttgtcgcccg agttcgccac
976981 acctgaagtc tggagggtgc ccgtattggc caagcccgag gtgaatctgc ccacgttgaa
977041 gaagcccgag ttaacgcggt gcctgcattc tggaagccgg agctagtgtc gctcgcgttt
977101 ccgaagccgg agctgccgtt gcccaagttc tggaagccgg agccactatt gccggagtta
977161 aagaagcccg agtgaccggt gcccgtgttg ccgaagcccg agttcgcgac gccttgagtg
977221 accgggctgc cgatgccggt gttcaggtcc cccgagttga agccgcccgt gttggtgtcg
977281 cccgaattac cccatcccgt gttgtcgtcg ccggcgtttc cgaagccgag gtttccagaa
977341 ccttcgtttc cactgccgat gttgaggaag ccggcatttc cgctgccgaa gttggtgttg
977401 ccgtcgtttc cgttgccgaa gttgaagaag ccggcgtttc cgctgcccag gtttgcattg
977461 ccgatgttgc cgttgccgag gttggcgttg ccgatattcc cgatgccgaa gttgtagtcg
977521 ccggtgttgc cgctgcccac gttgttgttg ccgatgttgc cgatgcccaa gaagttcccc
977581 acgccgatgt tctcgacgcc cagggccggg atcgcgagcg ctgctgggac ccccaccgca
977641 ccggccggcg cggcggtcac cacgggcggc aagacactca gcagctgctg ccacggggtc
977701 aactgcgaag ccaccgtcga ggctccaccg tgataaccca ccatcgccgc cacatcctgt
977761 gcccacaact gctcatagga cgcctcggtc gctgcgatcg ctggcaaatt ctgcccaaac
977821 agattcgaga gcaccaacga cagcaactgg ttgcgattgg ccgccaccaa tgctggatgt
977881 gcggtcgctg cccgcgcggc ctcatatact gcggccgcag ccttggcccc ggcagccgcc
977941 ccctcagcgc gtgccgtcgc cgcgttcagc caactcagat acggtgcggc cgcggccgcc
978001 atcgcggccg ccgccggacc ctgccacgcc gaacccggcc cagccgttag gcctgagatc
978061 agcaacgaaa acgaggccgc tgccatcccc agctcggcgg ccagcccatc ccaggccacc
978121 gccgccgcca gcatcggggc cggccccgca ccggcgtaga tccgcgccga attaacctcc
978181 ggcggcagca ccatgaaatt catcacgcca tcccttctca gctggccacc cccggcctag
978241 ccaccacgac ggcgggaccc ggctgccgcg atccgcgccg gcgggcctcg gtcgactaca
978301 gtggcgcgat cgctcgacaa cttgagcacc ttggcaaacg acggtatgtc caatcgcggc
978361 acattgtcgg ggttttcatc gaaatcctgt cgccaacccc gacagccggg ttccgggaag
978421 ccgggtgtcg cagtggttta ggtgtcgacg ttgaacaccc gggcaggcaa ccggccgtgg
978481 ctatttcggg tcgagatagg tttcgagtcc ggcttgtgcg ccgcgtgcgc cacggcgggc
978541 agcggcgagc tgccagacga agatggtcgt gccgagcaac cctgttgcca gcccggccac
978601 tgtcaccgga cgccaacttg cgaggccagg cacgacgaat gcggccaccg cggcgaccag
978661 ccaggcgagc gcgccgaccg cgatcaccgg ccacacctcg agcagcacgg gtggtagcgg
978721 tggcggctcg cgaatctgac tattttcgac gctcatcccg agtcaacata gcgcggcgat
978781 gatgcgtcgg cgaacggccc ggggtgggtg gcttccgcac cagcgggagg taccaccacc
978841 tgctggtggg tcgtcggccg gcaatgggtg gaaccgaaat cgtcgttcgc cgtttcagat
978901 gccctagtct gaacttccgt tgtaacctca gctgtgcttg acagcgatgc gcggctggcc
978961 agcgacttgt cattggcggt catgcggctc tcccgccaac tgcggtttcg gaacccgtca
979021 tcgccggtct cgctgtccca gctctcagcg ttgacgacgc tggccaatga gggcgcgatg
979081 accccgggtg cgttggcgat tcgtgaacgg gtccggccac cgtcgatgac cagggtgatc
979141 gcctcattgg ccgacatggg ttttgtagac cgcgccccac accccatcga cggtcggcag
979201 gtgctggtct cggtgtcgga atcgggcgcc gaattggtca aggcggcacg gcgggcccgg
979261 caggagtggc tggctgagcg gctcgcgacg ctgaaccgca gcgagcgtga catcctgcgc
979321 agcgccgccg atctgatgct ggctctggtc gacgaaagcc cgtgaccgaa ggccgttgtg
979381 cccagcaccc cgacggcctc gatgttcagg acgtctgcga tcccgacgac ccacggctcg
979441 acgatttccg tgacctgaac agcatcgacc gtcgtcccga tctgccgacc ggcaaggcgt
979501 tggtgatcgc cgagggtgtg ctggtggtgc agcgcatgct ggcctcacgg ttcacgccgc
979561 tggcgctgtt cggcaccgac cgccggctgg ccgagctcaa ggatgatctg gccggtgtcg
979621 gcgcgccgta ctatcgagcg tcggctgatg tcatggcacg ggtgatcggc ttccatctca
979681 atcgtggggt gttggcagcc gcgggccggg tgccggagcc gagcgttgct caggtggtcg
979741 ccggggcgcg caccgtcgca gtgttggaag gcgttaacga ccatgagaac ctgggctcga
979801 tcttccgcaa cgcggcaggg ctgagcgtgg acgcggtagt gttcggcacc ggctgcgctg
979861 atccgctcta ccgtcgtgcg gtccgggtat ccatgggaca cgcgttattg gtgccatatg
979921 cacgcgcggc cgactggccc accgaactta tgacgttgaa agagagcggc tttcgactgt
979981 tggcgatgac cccacacggc aacgcgtgca aactaccgga ggccatcgcc gcggtgtcgc
980041 acgaacggat tgcgctactg gtgggcgcgg agggcccggg cctaacggcg gccgcactgc
980101 ggattagcga tgtgcgggtg cgcattccga tgtcccgagg gaccgactcc ctcaacgtcg
980161 cgacggcggc cgcattggct ttctacgagc ggactaggtc gggccatcac attgggcccg
980221 gcacgtgaac gatcagcgcg accaagccgt gccctgggca acgggtttgg cggtcgccgg
980281 cttcgtcgcc gcagtcatcg cggttgcggt cgtggtgctg agcctcggcc tgatccgcgt
980341 gcatccgctg ttggccgtcg gtctcaacat tgtggcggtc agcgggttgg cccctacgct
980401 gtggggctgg cgccgcaccc cagtgctgcg ctggttcgtg cttggcgcgg cagtgggcgt
980461 ggcgggcgcg tggttggcgc tgctcgcctt gacgttgggg gacggctagc gacgcccgcc
980521 tgagcgcacc ccgagcagca catcttccca ggcaggtatg gcgggtttgc ctcgtcggtt
980581 gctgaccggc tgtgcggacg gcaccgtgag cgtcggctgt gcgggctcgg gctcatcgaa
980641 gtcgagatgg gcgaccggcg ccaacggccg tagcgggcga ttgaaggtgg ggttgatcag
980701 ctcatgggcc gtgtcgtcga tcgcggtggc ggttccgccg tgggcgccgg gggtgaagcg
980761 gaaatgcgcc aggttgtcgg agcggccagc cttccaggca agctgcaccg tccagcgact
980821 gtcctcgttg cgccacgcgt cccaggtgag gctgtcgggg ttaaggccgc gtgccaccag
980881 ggccgcggcg acggtctcct gcatggtcag caccgccggg ccgtcggcca ggaccgggtg
980941 cgccgcggtt gccagctcgg ccgcgcgcga gcgttccaac agtaccgggt gggcaaaccg
981001 gcggatacgg gcgatgtcgg agcccgatgc cgcagcgacc tgttcgacag acgcgccggc
981061 ccgaattcgg gcctgaatct ccttggggct cagcacgttg gtgacctcga tgtccagctg
981121 ggcttgctcc ggctggacgg agtcgtcccg tagcgccgcc cgcagtcggt cgtcgaccgg
981181 cagcttgaac tgttcggacg ggatggcacc ctggcagatg atgtttttgc cgtcggcatc
981241 gagcccaacg actttgagtt cccgcatggc ttctcctcgc aggctccggg caggacaacg
981301 ccggacctgt tacgtgcgca ctctagtgcg gtaaacgccg ttagcctcgt tgacacgcgg
981361 aggtgtcttg ccggcatggc gctggtgacc ggaatgcccg gtcacagccg cactaaggca
981421 gcgctaaagc cgctcgacca cccagtcgac gcactcggtg agggcgctga cgtcgtccgg
981481 ctcgaccgcg gggaacatcg cgacccgcag ctggtttcgg cccagtttgc gatacggctc
981541 ggtgtcgacg atgccgttag cccgcaggat cttcgcgacg gtcccggcgt cgacgtcgtc
981601 gacgaagtcg atcgtgccca ccacctgcga ccgcaacccg gggtcggtga caaatggcgt
981661 ggtgtagggc cgctcttgcg cccacgagta caaccgctgc gacgagtccg cggtgcgttt
981721 gaccgcccag tccaagccac cgttacccac cagccagtcg atctgttcgg ccagcagcgc
981781 cagcgtggcg atggccggtg tgttgtatgt ctggttcttc aagctgttct cgaccgcgat
981841 cggcagggac aggaaatcag gaacccagcg accggtcgcg gcgatggcct cgatccggct
981901 cagggcggcc gggctcatga tggccagcca caggccgccg tcgctggcga agttcttctg
981961 cggtgcgaag tagtaggcgt cggtctcggc gatgtcgacc ggtaggccgc cagcaccgga
982021 ggtggcgtcg atgacgacca aggcgtcatc ggagccctcc ggacggcgca ccgcaaccgc
982081 gaccccggtc gaggtctcgt tgtgggccca ggcgatcaca tcgactgacg ggtcggtttg
982141 cggctccgga gcactgccgg gatccgacgt gatgatgatc ggctcgccga cgaacgggtt
982201 cttggaaacg gcggaagcga acttcgcgct gaactcgccg taagtcaagt gcagtgagcg
982261 tttgtcaatc agcccgaagg cggccgcatc ccagaacgcc gtggcaccac cattgcccag
982321 tatcacctca tagccgtccg gcaacgagaa cagctcggcc aggcctgacc gaaccctgcc
982381 caccagattc ttgaccggcg cctgtcggtg cgacgtgccg aacaatgccg ctgcggtggt
982441 ggtcagcgtt tgcagttgct caagccggac cttcgacggg cccgacccaa agcggccgtc
982501 gcggggtttg atggcggtgg gaatttccag gtggggggtg agctggtcgg ccatgccatc
982561 agggtagtga ggggtaccga accgcggcga ctcgagcgga acgaaagcct gccggcacag
982621 gcgcgtagtg tgaacaagct cacatgcaag ccctggctgg tggctgggtc atagtgtcgc
982681 caagggtctg gataattccc ggtaccagcg gtaccgtgtt cgatacccgt gcggacgcac
982741 acctcggtgg ggaggcttcg aatggacagg acgcgcatag ttcggcggtg gcgccgcaac
982801 atggacgtgg ccgacgacgc cgagtacgtg gaaatgctgg ccacactgtc cgaggggtct
982861 gtgcggcgga atttcaaccc gtacaccgat atcgactggg agtcgccgga gttcgccgtc
982921 acggacaacg atccccggtg gatcctcccg gcgaccgatc cgttgggccg ccacccctgg
982981 taccaggcgc agtcgcggga acgccagatc gagatcggga tgtggcgcca ggccaacgtg
983041 gccaaggtcg ggctgcactt cgaatccatc ctgattcgcg gcctgatgaa ctacacgttc
983101 tggatgccca acggctcacc ggaataccgg tattgcctgc acgaatcggt cgaagagtgc
983161 aaccacacca tgatgttcca ggagatggtc aaccgtgtcg gcgcggacgt tccggggctg
983221 ccacggcggc tgcggtgggt ttcaccgctg gttccgctgg tggccggacc attgccggtg
983281 gccttcttca tcggcgtgct cgctggggag gagcccatcg accacacgca aaagaacgtg
983341 ttgcgcgaag gcaagtcgct gcatccgatc atggaacgag tgatgtccat tcacgtggcc
983401 gaggaagcgc ggcacatctc gttcgcccac gagtacttgc gtaagcggct gccgcgcctg
983461 acccggatgc agcggttctg gatctcgctc tacttccccc tgacgatgcg gtcgttgtgc
983521 aacgcgatcg tggtgccgcc caaggcattc tgggaggaat tcgacatccc gcgcgaggtc
983581 aagaaggagt tgttcttcgg ctcgccggag tcgcgaaagt ggttgtgcga catgtttgcc
983641 gacgcccgca tgctggccca cgataccgga ttgatgaacc cgatcgctcg gctagtgtgg
983701 cgactctgca agatcgacgg caagccgtcg cgctaccgca gcgagccgca gcgtcagcac
983761 ttggctgccg cgccggccgc atagcttgct acgagtgcac gcatgccgca cgtaattact
983821 cagtcgtgct gcaacgacgc gtcctgcgtc ttcgcatgtc cggtgaactg catccacccg
983881 acgccggacg agccgggctt cgcgacctcg gaaatgctct atatcgatcc ggtggcctgc
983941 gtggactgtg gtgcctgcgt aaccgcctgc ccggtcagcg cgatcgcgcc gaacacccgg
984001 ttggacttcg agcagctgcc gttcgtcgaa atcaatgcgt cgtattaccc gaagcggccc
984061 gccggcgtga agctagcgcc gacgtcgaag ctggctccgg tgactccggc cgccgaggtg
984121 cgtgtgcgcc ggcagccgct gacggtagcc gtcgtcgggt ccgggcccgc ggcgatgtat
984181 gccgccgatg agctgctggt ccagcaggga gtgcaggtca acgtctttga gaagctgccg
984241 acaccctacg ggctggtgcg ctccggggtg gcgccggatc accagaacac caagcgggtc
984301 acgcgactat ttgaccggat cgccggtcat cgccgcttcc ggttctatct caacgtcgag
984361 atcggcaagc atctaggcca tgccgagcta ttggcccacc atcacgccgt gctgtacgcg
984421 gtcggagcgc ccgacgaccg ccggctgacg attgacggga tgggactgcc gggcaccggt
984481 accgccacgg agctggtcgc gtggctcaac ggacatcccg acttcaacga tctgccagtc
984541 gatctcagtc acgaacgcgt ggtgatcatc ggcaacggga atgtcgcgct cgacgtggcg
984601 cgcgtgcttg cggccgatcc gcacgagctg gccgccaccg acatcgccga ccacgcgttg
984661 tccgcgttac gcaactcggc ggtccgtgag gtggtggtcg ccgcccgccg cggtcctgcc
984721 cattcggcgt tcaccctgcc cgagctgatc gggctcacgg ccggagccga cgtcgtgctt
984781 gacccgggag atcatcagcg agtactcgat gatctggcaa tcgttgccga tccgttgacc
984841 aggaacaagc tggagatctt gagcacgctg ggggacgggt cggcgcctgc gcgacgagtc
984901 gggcgcccgc ggatccggct ggcctatcgg ctcacgccgc ggcgcgtcct cggccagcgg
984961 cgggccggcg gagttcagtt ctcggtcacc ggaaccgacg agctgcgcca actggatgct
985021 ggcctggtgc tgacgtcgat tggctaccgc ggcaagccga ttcccgacct gccgttcgac
985081 gagcaggccg cgctcgtgcc caacgatggt ggacgggtca tcgacccggg caccggcgag
985141 ccggtgcccg gcgcatacgt cgcgggttgg atcaagcgcg ggcccaccgg gttcatcggc
985201 acgaacaagt cctgctctat gcagaccgtt caggcgttgg tggccgactt caacgacggc
985261 cggctgaccg atccggtggc tacaccgacg gcgctggatc agctggtgca ggcccgccag
985321 ccccaagcca tcggctgtgc gggatggcgg gccatcgacg cggccgagat tgcgcgcggc
985381 agcgccgacg gccgggtccg caacaagttc accgacgtcg ccgagatgct cgcggcagca
985441 accagcgcgc ctaaggaacc gcttcggcgg cgcgtgctgg cccggctgcg tgacctgggg
985501 cagccgatcg tgctaaccgt ccccttgtga tgacatggcg gcttggatct catccatgtt
985561 gacctcgcgc accggctggc ccagcgacca gtggtggccg aacgggtcgg cgaccacccc
985621 gtagcggtct ccccagagct ggtcctccaa ggcggtcacc accgtggcgc ccgcgttcag
985681 ggcacgctgg aacttggcgt cgacatcggt gacggtcaaa tgaatggtga ccggtgttcc
985741 gcccagcgag gtgggcgtca tcgacttgcc gccgcacatc tgcgggacgt cgtcgttgag
985801 catcaccgta aagccgttga tgcgtagtgc ggcgtggatc agtttgccat cgggaccggg
985861 gacgcgcccc agttcgacgg cgtcaaaggc cttgacgtag aagtcgatcg ccgaggcagc
985921 gtcgtcgacg acaaggtgtg gtgacagagc gggttcgacg ttgatcgcca tggtgtctcc
985981 ttgttgttgg tgtgctcggc caatccgggg cccggacagg ctcacggata ttgactcccg
986041 gcgcgatgga aaatcatcgc ggtgccgtca ttcaatcgcc ggacacgtgg ccaccgccca
986101 gcggtgtggc cagcaagccg aatctcaacc gcaggtgtgt tcaatgaata cttttccgtc
986161 acaacgtgat tgctgctttg tgtcgacaag cgcacttttc ggtctcgaca cgaatgctct
986221 tccgttacag cgcaagttga aactttctgc acgcaaccca tgccgaccat gtccgcgcca
986281 cccgctcaag cgccggtatg tggcgccttg gcggctaggc caaccgcccc cggcaacgcc
986341 agctgcacac gcccagcgaa gcgcgattgt cggtacgggt cgcgctgcga aacctgcctc
986401 ccattcgcac tagcaaaaga ctgtcgacaa gcgagcagtc gacttcaggc cgcgaccgaa
986461 ccggacgaga cgacaacaac atctgtcatc tcaatgcgct caccaggatc gctacaatat
986521 cagccagcta catgagccga tgtatatcca ggaaggctct gccgccgaca tgttggatcg
986581 ctcgcgcgga cagctgtacc ggctctacct ggctagtagg tgaattcaat ggcgcgttcg
986641 ctcattactc acccatgtgc acaataggtt cgcgtgcggc tcgccggcaa cgttggcaac
986701 atcccgattc ccattgattg cacgttgcgc ggcctaaccc aatattcccg gacgaacaac
986761 gccgaggtcg tgcagagcgt cgagacacac caccgtcccg ctaactttga tgccctcacc
986821 tgaggaaaac cacaggagcg tcaggtactc acccactgcg ggaattgcga tgacgttcaa
986881 accgatcgag gccgcgcagc tacgccagcg cgcagtgaac aggccgtaac tggaccgcgc
986941 ttgcgcaacg ttcgaaaagg gatccggtgg agcggcccga cgacaccaaa taggccatat
987001 cccccaaaga ctggtattga caaccgttct gatgccgcgt cagacttccc accacgccac
987061 ggaccgtcca acgccagaac tcaataccgt ctcgtcccag gcgaaaccgt gagcctagcc
987121 gatgatctcc tggcattggt cggactggac ttgatctgct cgctgacaag catacgtatc
987181 agtgctacga accgttcacg cggtgaacct gctgggcgca caaggagaat cgatggatta
987241 cgccaaacgc atcggccagg ttggggcgtt agccgttgtc ctgggggtgg gggcggcggt
987301 gactacccac gcgatcggct ctgccgcgcc gacggatccg agctcctcga gcaccgattc
987361 gccggtcgac gcgtgctcgc cgttgggtgg gtccgccagt tcgttggctg cgataccggg
987421 cgccagtgtg ccacaggtcg gcgtgcgaca ggtagacccc ggaagcatcc ccgatgactt
987481 gctcaatgcc ctgatcgact ttctggccgc ggtacgcaac gggttggtgc ccatcatcga
987541 aaaccgcact ccggtagcga atccgcaaca agtcagcgtc cctgaggggg gcaccgtcgg
987601 cccggtccgg tttgacgcct gcgaccccga tggcaaccgg atgaccttcg cggtgcgcga
987661 gcgcggtgca cccggtggac cccagcatgg catcgtgacc gtcgaccaac gaacggccag
987721 cttcatctac acagccgatc cgggtttcgt tggcaccgat accttcagtg tgaacgtcag
987781 cgatgacacc agcctgcacg tgcacggtct ggcgggatac ctgggtccgt tccatgggca
987841 cgacgacgtc gccaccgtga ccgtgttcgt cggcaacacc ccgaccgaca ccatcagcgg
987901 cgacttcagc atgctcacct acaacatcgc ggggctgccc ttcccgctat ccagcgcaat
987961 tctgccccgg ttcttctaca ccaaagagat tgggaagcgg ctcaacgcct actacgtcgc
988021 gaacgtccag gaggatttcg cctaccacca attcctcatc aagaaatcca agatgcccag
988081 ccagaccccg ccggagccgc ctaccttgct gtggcctatc ggtgtgccct tctccgacgg
988141 gctcaatacc ctctcggagt tcaaggtgca gcggctggac cggcagacat ggtatgagtg
988201 cacatccgac aactgcctca ccttgaaggg cttcacctac agccagatgc ggcttcccgg
988261 cggtgacacg gtcgacgtct acaacttaca taccaacacc ggtggagggc cgaccaccaa
988321 cgccaacctc gcgcaggtcg ccaactacat ccagcagaac tcggcgggcc gcgcggtcat
988381 cgtcaccggc gacttcaacg cgcggtactc cgacgaccaa agcgctctgt tgcaatttgc
988441 gcaggtcaac gggctcaccg atgcctgggt gcaggtagaa cacggcccca ccacaccgcc
988501 gttcgcgccc acttgcatgg tcggcaacga gtgcgagctg ctcgacaaga tcttctatcg
988561 aagcggccag ggagtgacgt tgcaggccgt cagctacggc aacgaggcgc cgaaattctt
988621 caattccaag ggtgagccac tgtcggatca cagcccggcg gtggtcggct tccactacgt
988681 cgcggacaac gtggccgtac ggtgacagcg gttgatcgcc aactggtttg ccgtcggcct
988741 caggcggtgg tgagtacccg ctcccagccg tcgaccgatt ccgggctgcg cgggcccggt
988801 cccacgtaaa tggccgacgg gcggaccagc ttgccgagtc gcttctgctc gagaatgtgg
988861 gcacaccagc cggcagtgcg cccacaggtg aacattgctg gcatcatgtt ggccggtacc
988921 cgggcaaagt ccaggaccac tgcggcccag aattcgacat tggtctcgat cgcccgatcc
988981 ggacggcgct ctcgcagttc tgacagcgca gcctgctcca ccgcgaccgc gacctcgtag
989041 cggggggcgc ccagccgctc ggcggccgcc cgcagcaccc gcgcccgcgg gtcctcggcg
989101 cggtagaccc ggtgcccgaa ccccatcagt ttctcgccgc ggtccaggat tcccttgacc
989161 acgctgcggg catcgccggc gcgttcgacc tcgtcgagca tcggcaggac gcgcgccggc
989221 gcgccaccat gcagcggtcc gctcatcgcc ccgattgcgc ccgacagcgc tgctgccaca
989281 tccgccccag ttgaggcgat cacacgcgcg gtgaatgtcg aagcgttcat gccgtgctcg
989341 gcggccgaca cccagtaggc gtcaatggcc tcgatgtgtc tggggtctgg ctcgccctgc
989401 cagcgcgtca tgaaacgtgc tgtgaccgtc gagcattcat cgatgattcg ctgcgggacc
989461 gccggctggt agatgccccg tgcggattgc gcgacatagg acagcgccat caccgatgcc
989521 cgggccagct gttggcgggc ggtggcgtcg tcgatgtcga gcagcggcgc atatccccag
989581 atgggcgcca gcatcgccag gccggcctgg acgtcgacgc gcacatcgcc ggagtgaatc
989641 ggcagcggga acggttcagc cggcggcagc ccgctgccga agttgccgtc caccagcagc
989701 gcccacacat cgccgaaggt gacccgctga cttaccaggt cttcgatgtc gacgccacgg
989761 tagcgcaggg ccccgccgtc tttgtccggc tcggcgatct cggtcgtaaa ggccaccacg
989821 ccgtcgaggc cggggacgaa attctccggg accactgtca tacgagaatt ctcacacctg
989881 gccccggcaa cgacgctacc ggctggtgcc aatcacggtg ccggcgatga gcgtgccgcg
989941 agaatcgtca cgagggtgag ccgcggcgtg ccgcctcgtc taccagttgt actcgggagg
990001 gcaagccaag tttggcgtag acgtgggtga ggtgggtttg cacagtgcgc ggcgagacga
990061 aaagccgttt tgcaatgtcc ttgttggata acccctcgct gaccaaccgc acgacgtcgc
990121 gttcggtcgg ggtcaacgag ccccacccgc gggccggtcg cttgcgttca ccgcgaccgc
990181 gttgtgcata tgcgatcgcc tcgtcggtgg acaaggcggc cccctcggcc caggcgcggt
990241 cgaaatcctc atcacccatc gcctcacgaa gcgccgtcac cgaggcctgg tagccggcat
990301 cccaaatctt gaagcggacc tgacgtgtct gttgccgaag ggcggctgcg gcaccgagaa
990361 ggcggacacc ttcggagtga ctgccgacct cgccggccag gccggcgagg agttccatgg
990421 catctggcat gccctggtag atgtgcagct cggcgccgca cgccagcgca gcatgagcat
990481 catcgcgcgc cagttctggt tcgccccgtg cggtggctac gcgcgcgcgt attgtcaacg
990541 ccaccattcg gtgccaccca ttggtcgcat cgacggcgtc gttggcgaac tgtcgtgcgg
990601 cgatcgcatc acctcctgcc agggctaact gcgccatcag gacctggtgc atggtcacct
990661 ggtcgggctg ggccctaaga atcggccgcg ccgcgtcgct ggcctcgagc gctgccgtga
990721 catcaccggc ggccagcgcg gcgtacgtca tcgccgcata accaatgcct tggtacacac
990781 cgcctaactc cgtcgcggct gcaatgcacg ccccggctat ggcgtgggcc gcgctggcgc
990841 cgcaatacgc cagcacctgg gcttgggtat ataggccgag aacctttgtc ggcacatcgt
990901 tggatgcctc ggcctcggca gtgatttccc tggatagctc gagggcttcg gtcagattgc
990961 cagcccacat ctgcgccaaa ctaagccaca agctgcagtg acgtgagacg aaccggtcgc
991021 cgatggtgtc ggccaggtcg cggcattctt ctgccgcggc tcgcaaagca ttcgggtcac
991081 ctgatatgca ggtccccacc ccccgccagt agaggatttg acacagcgtc catttgtcgt
991141 caatagcgcg tgccaggtcg gtcgcttcgg cgaaataggg cgcagcggcc tccgcgttgt
991201 agccactgct acagccgcag gcggtgagcg cccgcaccaa cgcggcgggg tcgcccacct
991261 cacgtgccat cgccagcgct tgttgtgcgg gagcgatgat gtcggtggcg cctaccggac
991321 tggtggccag ccaggtactg agcattgcct tgtcagcgag cgctcgcgcc cgtactgctg
991381 ttgacacagc gagccggtgg aacctttggt cttccaggat cgagttgaac caggacaacc
991441 cctcgcgcag gtgcgcccgc ccgaaccaga ttggttgcag cgaagatgcg agctgtaacg
991501 cttcggtgat atggccattt tcccggctcc aggcgaacgc ggcgcgcagg ttgtcgatct
991561 cggtctcagc ccgggcgaca agccgttggt gatcgttgtc cgcaggagtg ttgagtgagg
991621 cggccagcgc cgtgtagtag tcacggtgac gtgcgtgcac atcggcctcg ccggagtcgc
991681 ccagtttttc cagcgcgtac cgacgcaccg tttccagcag ccggtaccgc gtgcggccct
991741 ggcagtcgtc ggccaccacc agcgacttgt ctaccagcag ggtcagctga tcaagcaccg
991801 aaaacggatc caggtcgcta ccggcggcga ccgcccgcac cgcggcgagg tcgaacccgc
991861 cgacaaatgg cgccagtcgc cgaaacaaga tttgctcggt ctcggtcagc agtgcatgcg
991921 accaatcgat cgaggcgcga agtgtctgct ggcgctgcac cgcgccccgc acaccgccgg
991981 ccaacagccg gaaacagtcg tccagaccgt cggcaatctc gagcggtgac atcgaccgca
992041 cccgtgcggc agcgaactcg atcgccagcg gtatgccgtc tagccgccgg cagatctcgc
992101 cgacggccgc ggcgttgtga ttggcgatgg tgaacccggg ctgaactcgg ctggctcggt
992161 cagcaaacaa ttcgactgct tcgtcggtta tcgacatcga cggtacgcgc caggtgatct
992221 cgccggccat cccgatcggc tcccggctag tcgctaagat cgtcagctcc ggacaggccc
992281 ccaatagctc aacgaccaac gctgcgcacg catcgagaag atgttcacag ttgtccaaca
992341 ccatgagcat gcggcgattg ccgatgaatc ggcgaagact atccatggtt gaacggcccg
992401 gctgatcggg cagacccacg gcgcgcgcag ccgtggctgc gacgatcccg gattcagtga
992461 tcggggccag atcgacaaag cacaaaccgt cgcgaagttc ggatgcactc gcgatctgga
992521 ttgccagacg ggtcttgccg acaccgccgg ttccgcatag cgtcacgagc cggttctgcg
992581 ccaacagtgc ccgcacctca gcttatttgc gcacggcggc ccacaaatgt ggtgaactgc
992641 gccgggagaa tcgatgtcgg gctggatttg gccgtgcgca gtgggggaaa cttttcgcga
992701 atgtcggggt ggcacaactg catgacccat tcgggacgag gtagaccgcg cagcgggtgg
992761 cggccgagat cgacaagcca tgcatcggct gggagccggc cagtcactaa atcacctgtc
992821 gcagctgaca ggacaacctg acccccgtgt gccaaatcgc ggagacgcgc cgtccggttg
992881 atagtggggc cgacatagag ttcgtcgcgc aactgtacct cgcctgtatg aagacctata
992941 cgtagtcgga tcggcgcgag cgaggtccgc tgcagatcca gcgcgcatgc agcggcatcg
993001 ctagcgcgag tgaaagccgc aacgaagcta tcaccctcgt accgtttgac cggctgcacc
993061 ccaccgtgat tcgtgatagc ttccgacaca gtgtgatcca agtgcgcgat ggcggtcgcc
993121 atgtcctctg ggcacatttg ccataggtgg gtcgattcct cgacgtcggc taagagcaat
993181 gtcaccgtgc ccgtcggcgg caatctgctc acgtctaatc cctggttggc tataaggacg
993241 cgtctgcgtg ggggaacgaa ctcacatcgg ccaacatctg gtggagccgc atagcagcgg
993301 agcgaatggt accggagatc cagcgatcct agcgcagata tacgaaccct ggcgacgcac
993361 tttgcgcatg ttggcggatg atcttcgccc cgcaggatcg catggtcgat gtcgatgttg
993421 ggaggaaggc tgttatgaac tgcgttgaag agcacgatac gtgtctgacc actgctatca
993481 cgtcatcgca acaccttcgc ggcgccgcga agccaataag cacactacag ttcggggaag
993541 acacctggcc catcctcgaa acaggcctct cgcagcgatg ttcattaccg cccaaagaga
993601 ttgtcttcgg cgctgcacgg tgggcgctcg cggcggcccg cgggatgcta ccgcggccca
993661 cgaccgacag cccaccgcag cgtcagcgct acccgaagcg ctaccgattc ctggagcact
993721 cctgcctaga acgcgagatg cgtcgactat agaacagcgt cgcgtgtttg tctcggtagc
993781 tgctctgtat agtatgcgtt gcttaaccgc atgtgggagg gtgattttgg gctgttctgg
993841 ggggtcggag cgatgaccgg gcgatgtccg acggttgccg tggtcggagc gggtatgtcc
993901 ggaatgtgcg tcgcaattac gttgctgagc gcagggatta ctgatgtctg catctatgaa
993961 aaggccgacg atgttggcgg aacgtggcgc gataacacct atccaggtct gacatgtgat
994021 gtgccgtccc ggctctatca gtacagcttt gccaagaatc cgaactggac ccagatgttt
994081 tcacgcggag gcgaaatcca agattacttg cgtgggatcg ccgagcgcta cgggctgagg
994141 caccggattc ggtttggcgc cacggttgtc agcgcccgat tcgacgacgg ccggtgggtg
994201 ttgcgcaccg attccggaac ggagtcgaca gtagacttct tgatttcggc caccggcgtt
994261 ttacatcatc cccgaatacc gccgatcgct ggtttggacg acttcagggg gacggtgttt
994321 cactcggctc gctgggatca cacggttccg ctgctgggac gccgaatcgc ggtgatcggt
994381 accgggtcca cgggcgtaca actcgtctgc ggcctggctg gggtcgcggg taaagtcacc
994441 atgttccagc gcaccgcaca atgggtgctg ccgtggccta accctcgata ctcgaagctg
994501 gcgcgtgttt tccaccgcgc ttttccgtgt ctgggttcgc tggcctataa ggcatatagc
994561 ctttccttcg aaacgttcgc ggttgcgctc agcaatccag gtttgcaccg aaagctggta
994621 ggggccgtgt gtcgcgccag cttacgtcgg gtgcgtgacc cccgactgcg tcgggcactg
994681 acgcctgatt acgagccgat gtgcaaacgg ctagtgatgt ccggcggatt ctatcgggcg
994741 attcagcgtg acgacgtcga attagtcacc gccggtatcg atcacgtcga acatcggggc
994801 atcgtcaccg atgatggtgt gttgcacgag gtggacgtca tcgtgcttgc cacggggttt
994861 gactctcatg catttttccg gccgatgcag ctgaccggtc gcgacggcat caggatcgac
994921 gatgtgtggc aagacggtcc gcatgctcat caaaccgtcg caatacctgg atttccgaac
994981 ttctttatga tgttggggcc acacagccca gtgggaaact tcccgctgac agcggtcgcc
995041 gaatctcagg ctgaacacat agtgcagtgg ataaagcgat ggcgccatgg tgaattcgac
995101 accatggaac cgaagtcagc tgctaccgaa gcatataaca cggtgttgcg ggccgcgatg
995161 ccgaacaccg tctggaccac cggctgcgac agctggtacc tgaacaaaga cggtattcct
995221 gaggtttggc catttgcacc ggccaaacac cgcgccatgc tcgctaacct acatcccgaa
995281 gaatacgacc tgcgacgcta tgctgcggtg cgcgcaacta gtcggcctca aagcgcttga
995341 agcctatcga ggtgctggac ggtgacgttc gcgcgggatc ggccactaat cccgttctga
995401 cggcgctgac aaaggttata gcggtgacca ttggcgcagc ttcggtatcg gcttcgggca
995461 ccgctcggcc gacgcggcgc agatactcgg ccaatggagt agcggtcgcg cgccagcctc
995521 gctcatcgaa ccattccgtg gcccgcgccc accgctcgtt gtagaccatt tgaaagaacc
995581 tgcgcgggtc gccttgggcg ttcgcggcgc gttctcgttc gagcttcgct gcgaattcgc
995641 aagggtccag tggagttgct tcctcgacag caacgtggct accggggcta gccaaggtgt
995701 cgatgccgat aaacaggcgc tgctgggcct cggccgagag atagaccagc aggccctcgg
995761 cgatccaagc cgacggccgg ttggcatcaa atccgttgtt acacaaggct atctgccact
995821 catcgcgcag atcgacagca accgaccgac gttgggctcg cggccgtatg tgatagtcgg
995881 cgagcaccgc gttcttgaag tcgaggacct gaggtcgatc caactcgaag attgttgtcc
995941 cgattggcca ttgcaatcgg aatgcacggg aatccaatcc tgcagccaag atgaccacct
996001 gcttcatgcc ggcggccgtt gcccgggaga aatactcgtc gaaatacctg gtgcgggcac
996061 cttggaagtt gacgaaatgc tcaccgaagt ccccggttgt cagatagtga tcgggcagct
996121 tgccgtccaa tacgtcggcc cattcaccac ctgcggcacg gcagaaaacc tcggcatagg
996181 gatcgatggc cagcggatcg gccttctgcg tctccaatgc tcttgcggcg gctaccaata
996241 gtcctgtcga accaacactc gtggtgacat cccagctatc gtcctcggtc cgcattcatc
996301 gaactctagt tgctccagtc cgcccaccgc tgtcggtatc ccagcgcagt cggccgtgca
996361 cacatatctg cgcggtggac ttggtacttc tacgcgcatt cgccgatgtt ttgcgatccg
996421 cggcgggtct atggtgccat ttatgtgcca ggatcggtct tcaataacaa cgtcgcgaag
996481 cgaggggtcg tgacgtgaga gggctcgctt atgccggcgg tggatgccca gtagggcgac
996541 ggtccaggaa ttctcagaca gttatccgtt ctgccacaat ggattccggc cgatcatgat
996601 gccaaagatc gtctccgtcc aacattccac tcgccgccac ttgacgagct ttgtcggtcg
996661 caaggctgag ctgaacgacg tgcggcggct cctgtccgac aaacgactgg tgacgcttac
996721 cggtccggat gggatgggga aatcccgtct cgcgctgcag atcggcgccc agattgcaca
996781 cgaattcact tatggccgtt gggattgcga cttggctacg gtcactgacc gagactgcgt
996841 gtccatctcg atgctgaatg ccttgggctt gcctgtccag ccgggtttgt ctgcgatcga
996901 cacgctcgtc ggtgtcatca atgatgctcg ggtgctgctg gtgttggacc attgtgagca
996961 tttgctggac gcgtgtgccg caataattga ttcgctgtta cgttcctgtc cgagattgac
997021 gatcctgacg acaagtaccg aagcgatcgg gttggcgggc gagctgacct ggcgggtgcc
997081 cccgttgtcg ctgaccaacg atgccatcga gctgtttgtc gaccgggcac gccgagtgcg
997141 gtcggatttt gcgattaatg ccgataccgc ggtgacggtc ggggaaatct gccgacgctt
997201 ggacggtgtg ccactggcga tcgagctggc cgcggcgcga acggacacct tgtcgccggt
997261 ggagatcctt gctggtctaa atgaccgatt ccggctggtg gccggtgctg cgggcaacgc
997321 ggtgcgcccc gaacagacgc tgtgtgccac ggtgcaatgg tcgcatgctc tgttgagtgg
997381 acctgagcgt gcgttgttgc accggttggc agtcttcgcc ggcgggttcg accttgacgg
997441 cgcccaggcg gtcggtgcca atgacgagga cttcgagggc taccagacac tcggccggtt
997501 tgccgagttg gtggacaagg catttgtcgt cgtcgaaaac aacaggggcc gagcgggata
997561 ccggttgctg tattcggtgc gtcagtacgc gttggagaag ctcagtgagt cgggagaggc
997621 cgacgccgtg cttgcgcgtt accgcaagca cctcaaacaa cccaaccagg tagtgcgtgc
997681 tgggtcaggc ggggttcggt actgatgcgt gaacgtagct taaccgtcgg tgggaattga
997741 ccgcgccacc catagcagtc gagaggaaca cccgcagcaa agtgcgccaa caacaggagg
997801 ctgacgtcgt tgccctgggt cgaaagccag ggctgctatg tgtgccggaa aggttccgtg
997861 caatggatct tccgatggca gccgccgatg ccttattcct atgggccgag acgccgacgc
997921 ggccgctgca tgtcggcgcg ttggccgtgc tgagtcagcc cgacaacggg accgggcgtt
997981 acctgcgcaa ggtgttctcc gccgcggtgg cccgtcagca ggtggcgccg tggtggcgcc
998041 gacgcccgca ccggtcgctc acctcgctcg ggcagtggtc ttggcgcacc gagaccgagg
998101 tggacctgga ttaccacgtg cggcttagcg cattgccgcc acgggccggt accgccgagc
998161 tgtgggcgtt ggtttctgaa ctacacgccg gcatgctgga ccgctcccgc ccgctatggc
998221 aggtggacct gatcgagggt ctacctggcg ggcggtgcgc ggtctacgtc aaggtccacc
998281 atgcgctggc ggacggagtc tcggtgatgc ggcttttaca acggatcgtc accgcggacc
998341 cgcatcagcg tcagatgccc accttgtggg aggtgccagc gcaggcgtcg gtggccaaac
998401 acacggcacc gcgcggttcg tcgagaccac tgacgttggc caagggggtg ctgggtcaag
998461 ccaggggcgt cccgggcatg gtgcgcgtag tggccgatac cacgtggcgg gcagcgcaat
998521 gtcgcagcgg gccgctgaca ctggccgcac cacacacccc gctgaacgag ccgatcgccg
998581 gggcccggtc cgtggcaggt tgttcctttc cgatcgagcg gctgcgacag gtcgccgaac
998641 acgccgatgc caccatcaac gatgtcgtgc tggccatgtg cggcggggcg ttacgtgcgt
998701 acctgatcag ccggggagcg ttaccgggtg cgccgctgat agcgatggtg ccggtttcgc
998761 tgcgcgatac cgcagttatc gacgtgttcg gccagggtcc aggcaacaag atcggtacgt
998821 tgatgtgttc gctggcgacg cacctggcca gtccggtcga acggctgtcg gcgatacggg
998881 caagtatgcg cgacggcaaa gccgcgatcg ccggccgaag ccgaaaccag gcgctggcta
998941 tgagcgcatt gggcgccgcc ccgctcgccc ttgcgatggc cctggggcgc gtgcccgcgc
999001 cgctgcgccc accaaatgtg acgatctcca acgtgccggg cccgcagggc gcgctgtact
999061 ggaacggcgc tcgcctggac gcgctctacc tgctctcggc acctgtcgat ggcgcggcgt
999121 tgaacatcac ctgtagcggc accaatgagc agatcacttt cggtttgacg ggctgccgtc
999181 gtgccgtccc cgcgctgagc atcctgaccg accagctcgc ccacgaactc gagctactcg
999241 ttggcgtcag tgaagccggc ccagggacca gacttcgaag gatcgcaggg cgccgttaaa
999301 cggacgccgc gagtcatcac ccggccgagc gcgcagcggc ttaccttacg cgcggccgcc
999361 catggtgcca gagaccccac cccgggcagg cgggtcatcc cgatagcgac taccttcagc
999421 tataagcact tagtggggca gccatatcag ccaaagcgcg aaggggttct cgtggccgac
999481 accgacgaca ccgcaaccct ccgttacccg ggaggcgaga tcgacctgca gatcgtgcac
999541 gccaccgaag gcgccgacgg cattgcgctc gggccgctgc tggcaaaaac cgggcacacc
999601 acgttcgacg tcggcttcgc caacacggcc gccgctaaaa gctccatcac ctacatcgac
999661 ggagatgccg gcattctgcg ttatcgcggc tacccgatcg accaactggc ggagaagtca
999721 accttcatcg aggtctgcta cctgttgatt tacggcgagc tgcccgatac cgaccagctt
999781 gcccagttca ccggccggat ccagcgccac accatgctgc acgaggatct caagcggttc
999841 ttcgacggct ttccgcgcaa tgcccacccg atgccggtgt tgtccagcgt ggtcaatgcg
999901 ctgtcggcgt actaccagga tgctctggac cccatggaca acggtcaagt cgagctgtcg
999961 accattcggc tgctggccaa gctgcccacc atcgccgcgt acgcctacaa gaaatcggtc
1000021 ggccagccct tcctctaccc agataactca ctgacgctgg tggagaactt cctacggttg
1000081 acgttcggat ttcccgccga gccctaccag gccgaccccg aggtggtgcg ggcgctggac
1000141 atgttgttca tcttgcacgc cgaccacgag cagaactgct cgacgtcgac ggttcggctg
1000201 gttggctcgt cgcgagccaa cctgttcacc tcgatctcgg gtggcatcaa cgcactatgg
1000261 ggtccgcttc atggcggcgc caatcaggct gtcctggaga tgctcgaggg cattcgcgac
1000321 agcggcgacg acgtcagcga gtttgtacgc aaggtcaaga accgcgaggc cggggtcaaa
1000381 ttgatgggtt tcggtcatcg tgtctacaag aactacgatc cgcgggcccg catcgtcaag
1000441 gaacaggccg acaagatcct ggccaagctc ggcggcgatg actccttgct gggcatcgcc
1000501 aaggagctcg aagaggcggc gctgaccgac gactacttca tcgaacgcaa gctttacccc
1000561 aacgtcgact tctacaccgg cctgatctac cgggccctcg gcttcccgac caggatgttc
1000621 accgtgttgt ttgccctggg caggcttccc ggctggatcg cgcactggcg tgagatgcac
1000681 gacgagggcg acagcaagat cggccggccc cgccagatct acaccggcta cacggagcgc
1000741 gactacgtca ccatagacgc gcggtaggcc ggcgagcaga cgcaaaagcc ccctaaaccg
1000801 gcaggtatta ggggcttttg cgtctgctcg ccaggcaagc cagcactgcc atcgcggcgt
1000861 tgtgaccgcc gatgcccgac accgccccgc cgcgacgggc acccgagccg cacagcatga
1000921 tccgctcgtg gtcggtggct acgccccact gccgtgccgg tgtgtccagc ggatcgtcgt
1000981 tgtcagcgaa cggccaggac aacgcaccgt ggaagatgtt gccgccggtc atcccaagcg
1001041 tccgctgcag gtccagggtg gtcgtcgtct cgatgcatgg cttgctctgc gcatcggtcc
1001101 aaagcacgtc ctgaatcggt tcggccagaa cggaattcag cgacgctagg acggctgccg
1001161 tcagccgttc ggctaagcct tcggtgtcgc cgaacaccga gtgcggtgtg tgcaagccga
1001221 acaccgtcag cgtctgagcg ccggcatcgc gcaaccgggc ggacaggatg ctcgggtcgg
1001281 tcagcgaatg gcagtaggct tcgcagggta ggggatccgg caaccgcccg ctggctgctt
1001341 gcgagtacgc ggcatccaat tggctccatg tctcgttgac gtggaacgtc ccggcaaatg
1001401 cttgctgcgg tgtgacactg tcgtcgcgca accgggggag tcggcgcacc accatgttga
1001461 ccttgacctg tgcgcccggg gccagtgccg caaccggttc accgagcagg ctggccagca
1001521 ccgccggtgt gaccccgacc agaacgaacc ggccccggac caaatgctcg gcaccgtcgc
1001581 taccgtcgct gtggtagcgc accgtaccgt ctggatcaag ggcgaaaacg tctgcaccgg
1001641 tgactatttc ggcgccgtgg cgggcagctg ccgtggccag ggccgaggtc accgacccca
1001701 tgccgccgat tgggacgtgc cagactccgg tgcccccacc gaccaggtga tacaggaagc
1001761 agatgttctg catcagcgac ggttcgtgca tgcgggcgaa ggtgccgatc agcgcgtcgg
1001821 tggcgatcac cccgcgtagc aggtcattgg ccaccgcgcc ggcgatggca tgcccgatcg
1001881 gctcgtcgac catggcttgc caggcagcgg ccgcctcgtg gccgccgtat tccacaatgt
1001941 cgcggcgggc ctgctcgcgg gtgcgcagcg gctcgatcag ggtgggccac agccgtgcgg
1002001 tcaccagccg gcagcgccgg tagaacgcgg cgaagccgtg cgcatccggc gcggcgccga
1002061 tcgccgcgag gtgcgctgcg cgtggttcgc cggtgggccc gatgagcagg ccagagcgcc
1002121 cggccgtggc tggggcaggg gtgtatgagg aaaatggccg ccgcgccaac cgcaccggag
1002181 cgccgaggtc ggcgacgatg cgcgacggca gcaagctgac caggtacgag tagcgtgaca
1002241 gcgcgacctc gacaccgtcg aaggcctgta tcgacaccgc ggccccccca gtctgtgcca
1002301 gccgctcgag cagtcgcact cgaagcccgg cccgggccag gtaggcggcc gcgaccaagc
1002361 cgttgtgacc gccgccaacc acgacaacgt cgaagtccct gtcgtgatcg ctcatagtga
1002421 cggcggctat cgagacggat ctagccggtg tacccctcga cttggtcggc gggacgcacg
1002481 actgcttcgc gcgggtcacc accggtttgg cgcaatgccc gtcgctgtcg gagcaggtcc
1002541 cagcactggt cgagttcgat ctcgatgcgg cgcagttgct gctgctcctc ggactcgctg
1002601 atgccaccgt gccgcagctg cgctcgcaac gccttctcct cggccaccag gtcacggatg
1002661 tgtgccaggg tctcgctgtc tgtcggtttg cgtcccttgc ccatggctcc agtgtgcccg
1002721 atttgacgcg gtgtcccggc accgactcgg taggctgcat atcgcctgca gcacggacga
1002781 gacgcgttcg acgacctgag ggagtggcgt agtggcttct aaggcgggtt tgggccaaac
1002841 acccgcgacc accgacgcgc gacgaactca gaaattctac cggggctcgc cgggccgtcc
1002901 gtggctgatt ggcgcggtgg ttattccgtt gctgatagcg gcaatcggtt acggtgcatt
1002961 cgagcggccc cagtccgtta ccggaccgac cggtgtgttg ccgacactga caccgaccag
1003021 cacccggggc gcttctgcgt tgtccttgtc tttgctgtca attagccgca gcggcaacac
1003081 cgttactctg atcggtgact tccccgatga ggccgccaag gcggccttga tgacggcgct
1003141 caacggcttg cttgctccgg gcgtgaacgt catcgaccag attcacgtcg atcccgttgt
1003201 gcgatcactt gatttctcaa gtgcggaacc agttttcacc gccagcgtgc cgattcctga
1003261 ttttggcctc aaagtcgaaa gggacaccgt caccttgacc ggaactgccc cttcatccga
1003321 gcacaaggac gcagtgaagc gcgcggcgac cagcacctgg cctgacatga aaatcgttaa
1003381 caatattgag gttacggggc aggcaccgcc aggacccccg gcctccggcc catgtgccga
1003441 cctgcaatca gccatcaatg ccgtgacggg tggacccatc gcgtttggca acgacggggc
1003501 tagtctgatc ccagccgact atgaaatcct gaaccgggta gccgacaagc tcaaggcatg
1003561 tccggacgct cgggtgacga tcaacggcta caccgacaac accggcagcg aaggtatcaa
1003621 tatcccgttg agcgctcagc gagccaagat agtcgccgac tacctggttg cccgcggagt
1003681 tgccggcgat cacattgcca ccgtgggtct cggttcggtg aatccgatcg ccagcaacgc
1003741 cacacccgag gggcgcgcca agaatcgtcg cgtcgagatc gtggtcaact aaggagaacc
1003801 cagcatggat tttgtgatcc agtggtcgtg ctacctgctg gcgttcctgg ggggctcggc
1003861 tgttgcctgg gtagtcgtca ctctgtcgat caagcgcgcc agccgtgatg agggtgctgc
1003921 ggaggcgccc agtgcagccg agacaggcgc acagtgatgg aacacgtgca ctggtggctg
1003981 gcgggcctgg cgttcacgct cgggatggtg ctgacgtcga cgctgatggt ccggcccgtc
1004041 gaacatcaag tgctggtaaa gaaatcggtc cgcgggtcaa gcgctaagtc caagccgcca
1004101 acggcgagaa aacccgccgt caagtcgggc accaagagag aggagtcgcc gacggcgaag
1004161 accaaggtgg caacggagtc tgctgcggag cagatcccgg ttgccgggga gcccgcggcg
1004221 gagccgatcc cggtcgccgg cgagccggcg gcgcgtattc cggtggttcc gtacgcgccg
1004281 tacggcccgg gctcggcgcg cgctggtgcc gatggcagcg gaccgcaggg gtggctggtg
1004341 aagggccgct cggacaccag gctctactac actcccgaag atccgacgta cgaccctact
1004401 gtcgcccagg tttggttcca ggacgaggag tcggcagcgc gggcgttttt cacgccgtgg
1004461 cgcaagagca cacggcggac atgaggtcag ggccgcaggg ctaactgggc ccgggaaggc
1004521 gcaacacgag gcgcgcgcca cccagcgggc tgttctccag cgacgcggtg ccgccgtgca
1004581 actgggcctg ttgggccacc aacgccagcc cgagacccga ccccgaatga gatgccgtgg
1004641 acccgcggga gaaccgctcg aacaccactt ggcgctcacc ttcgggcact ccgctgccgt
1004701 tgtcgtcgat ggcgatctcc acgccggccc gcgagctgac cgcggagagt tgaaccaggg
1004761 tggcgccgcc gtgcttgacc gcgttggcga tggcgttgtc gacggccagg cgcaacccgg
1004821 ccggcaaacc cacgatgatg caggtcggcg acggcaccag cgatacatcg agatcggggt
1004881 agatccgggc cgcgtcgtgg gcggcgcggt cgagcaggtc ggtgatatcg accggcacgt
1004941 gatcgtccga ggtcgacagt tcgccctggg ccaaccgctc cagcgcgctc agggtggcct
1005001 caatgcgcga ctgggtgcgg atgacgtcgt tgagcacttc tttgcgctgg tcgtcgggca
1005061 gatccagggt ggacagcacc tccaggttgg tgcgcatcgc ggtcagcgga gtgcgcagct
1005121 cgtgggagga caccgccgcg aagtcacgcg ccgacgcaag cgcctccttg gttcggttct
1005181 gctcgttcca gatgcgctgc agcatgccgc gcatcgcctc ggcgatctcg atggcttcgc
1005241 tggcgccgtg tacttccacg cgtggcgcct cgtcgcccgc gtcgatggac cgggtctgct
1005301 cggcgagctg cttgaacggg cgtaccgcga acgcggccaa cagccaggcg aacaccgccg
1005361 ccgcgccgat ggcgaaggta cagatcagca gcacccggcg gtgcaggttg ttggtctcgg
1005421 ctacggtggc gtcatacgtc gcgcccaccg ccaccgacgt cggctcgggc ccggggatct
1005481 ccaccgtgcg cacgcggtag cgcaccccgc ggacgtaggt gtcggcgtag tcgtcttgca
1005541 gtttgggcag cgtgatgtcg gaattcgact tgatcacgtt gccacggcgg accgtgatga
1005601 gggcgtcctg gtcgttcggt gagcgcggga tctcgtcgag gccacgcggc acgaacggga
1005661 tcgcgaaacc cgcggcctcg tcgagccggc ggtccagccg ctccttgcgg tcgttggtga
1005721 tcccgaccca gacgacggtg ccgacaatga gtaccgggat cgcggcgccg atcgccgtcg
1005781 cgaccaccac ccgggttcgc agcgagggcg tacgggcgaa gatccgcgac agaatattca
1005841 tgcatgcccc gtcactgcat acgcagcacg aatccgactc cgcggacggt atgcagcagc
1005901 ctagggccac cgccggcctc cagtttgcgc cgcaggtacc cgatgaagac gtccaccacg
1005961 ttggtgtcgg cggcgaagtc gtagccccac accaattcca ggagttgcgc tcgggagagc
1006021 accgcggtct tgtgctcggc cagcaccgcg agcaggtcga attcgcgctt ggtcaggtcg
1006081 acgtcgacgc cgttgacccg ggcccgccgg ccggggatgt ccacctccag cgggcccacc
1006141 gtgatggttt ccgaggacga cgttgcagtg gagccgcggc ggcgcagcag cgccttcacc
1006201 cgtgccacca gctcggccag cacgaacggt ttcaccaggt aatcgtcggc gccggcctcc
1006261 aatccggcca ctcggtcatc gacagagctg cgtgcggata gcacacagac cgggacgtcg
1006321 ttgtccatcg cgcgtagtgc cgtcacgacg ctgactccat cgagcactgg catgttgatg
1006381 tcgagcacga tcgcgtccgg ccggttctcg gtggcgctgc gcaaggcctc ggcgccgtcc
1006441 accgcggtcg ctacctcgaa tccggacagc cgtaagccgc gttccagcga ggcgagcaca
1006501 tcggagtcgt cgtcgacgac caacacccga ggtgaggtca caccagtgtc catgccgccc
1006561 attttgcctg attaccgtcc agcagggtgg gagggtgagc cgccgggtcg cgtgctgggc
1006621 gagcagacac agagtcgcat caaaaccgcc gattttgtgc gactctgtgt ctgctcgcgg
1006681 ggtgcgcgcg ggttagtcgc ggggcaaccc gatccggcgg tagcgttgca accgagtcgc
1006741 gaggcgttcc ggggccggta tcttccgtaa cgcgtgcact tcggcggcga tggcgttcga
1006801 cagtcgtagg gcgaactcga tcggctcgtc tgcggcgtcg gggtactccg gcacgatggt
1006861 gtcgacaatc cccgacttca gtaggtcggc cgaccggatg ccttgggcgg cagcgagttc
1006921 ggcggcatga gcagtgtctc ggaacacgat cgcgctggct ccttcgggag gcaagggcgc
1006981 cagccagccg tggagtgcgg ccagcacccg gtcggcgggc aacatcgcca gcgccggccc
1007041 gccgctgccc tggcccagca ggatcgacac ggtcggggta tccagcgtga cgagctcggc
1007101 caggcaatgc gcgatctggc cggccagccc gccctgttcg gctgcggccg acaacgcggg
1007161 tccggccgcg tcaatgacca gcaccagcgg caggcacagc tcggcggcga gcgccatccc
1007221 gcgtcgggct tcgcgtaacg cagcgggccc gacagtgctt cccccgccgc ctactgccct
1007281 ttgctggccg aggaccaccg tgggttggcc gccaaagcgg gccagcgcca gcagcgtggt
1007341 cgccgcttcg ccttgatcgg ttcctgacaa caacacccgg tcggtggcgc cgtgtcgcag
1007401 tagctgcctg acgcccggcc ggtccggccg gcgcgatgcc accaccgagt cccacgtggg
1007461 cacatcgggt acgggcgcgg gcgtctgcgg tgccggaagc ggttcgggag cgtcgatgag
1007521 caccgtcaac gcacgatcca gcatcggtcg tagccggtcc agtgcaacga cgccgtcgat
1007581 gatcccatgc cgccgtagat tctcggcggt ttggacgccg gatgggaagg ggtcgccata
1007641 gagcaactca tagacccgtg gtcccagaaa gccgatcagg gcgcccggct cggcgacggt
1007701 gagatgcccc agcgagcccc acgacgcgaa aactccaccc gtggtcggat ggcgcaaata
1007761 gaccaggtag ggcaggcgcg cctggttgtg cagctggatg gccgcagcga tcttcaccat
1007821 ctgcagaaac gcgaccgtgc cttcttgcat gcgggtgcct cccgagcttg gtgacgccag
1007881 tagcggcagc cgctcggcgg tcgcccgctc gacggcggcg gtgatccgtt cggccgctgc
1007941 caccccaatc gagccgccca ggaagtcgaa ctcacaggcc accacggcca cccgccgccc
1008001 gaatacgcgt ccctcaccgg tctgcaccga ttcgtccgcg ccggtggccg cccgagcggc
1008061 ggccagctcc cgcgcatagg agtcggctac cggcaccgcc agcggctcgc tatcccagct
1008121 gacgaaagat ccccggtcta gcaccgcgtg ccgcagttgg tcggtcgtga tacgactcac
1008181 gcgatgaggc tatataggct gacccaatga tcggtatcac ccaggcagaa gccgtgctga
1008241 ccattgagct gcaacgcccg gagcgccgca acgccttaaa ttcccagctg gtcgaggagc
1008301 ttacgcaggc catccggaaa gccggggatg gatcggctcg ggcgatcgtg ctgaccggcc
1008361 aaggcaccgc gttctgcgct ggcgcggacc tgagcggaga cgcattcgcc gccgattatc
1008421 ccgaccggct catcgagctg cacaaggcga tggacgcctc cccgatgcca gtggtcggcg
1008481 cgatcaacgg tcccgccatc ggcgccggct tgcagcttgc catgcaatgc gacctgcggg
1008541 ttgtcgcgcc cgatgccttc ttccagtttc cgacgtcgaa atacggtctg gccctggata
1008601 actggagcat ccgccggctg tcgtcgttgg ttgggcacgg acgtgcccgc gcgatgctgc
1008661 tcagcgcgga aaagctgacc gccgagatcg cactgcacac cggaatggcg aatcgcattg
1008721 gcactttggc cgacgcccag gcctgggccg ccgagatcgc caggctggca ccactggcta
1008781 tccagcacgc caagcgggtg ctcaacgacg acggcgctat cgaggaagcg tggccggccc
1008841 ataaggaact cttcgacaaa gcctggggca gccaggatgt catcgaagcg caggttgccc
1008901 ggatggaaaa gcggccgccg aagttccaag gggcttaacc gtcatggtgc gccgagcgct
1008961 acgactggcg gccggcaccg cctcgctggc cgccggcacg tggctgttgc gtgcgctgca
1009021 cggcacgccg gccgcgctcg gtgccgacgc ggcgtcgatc agggctgtgt cggagcaatc
1009081 gccgaactat cgtgacggcg ccttcgtcaa cctggatccc gcgtcgatgt tcaccctgga
1009141 tcgcgaggag cttcggctca tcgtgtggga gttagtggcc agacacagtg cgagccggcc
1009201 ggcggcgccg atcccgttgg cctcgccgaa tatctaccgg ggtgacgcca gccggctcgc
1009261 cgtcagctgg ttcggtcact cgacggcgct gctggaaatc gacggctacc gggtgcttac
1009321 cgatccggtg tggagcgatc ggtgctcacc gtccgacgtc gtcggccccc agcgcctgca
1009381 tccgccgccg gtgcaactgg cagctctccc ggccgtcgac gccgtggtca tcagccacga
1009441 ccactacgac catctcgata tcgacaccgt ggttgcgctg gtcggcatgc aacgggcccc
1009501 gttccttgtg ccgctcgggg tcggcgccca ccttcggtcg tggggtgttc cgcaggatcg
1009561 cattgttgag ctcgactgga accagagcgc tcaggtcgat gagctcaccg tggtctgcgt
1009621 gccggcacgg cacttctcgg gacggttcct gagccgcaac accacactgt gggcctcgtg
1009681 ggcgtttgtt gggccgaacc atcgcgccta cttcggcggt gataccggat acaccaagag
1009741 cttcacccag atcggcgcgg accacggacc gttcgacctg accctgctgc ccatcggggc
1009801 ctacaacacg gcgtggccgg acatccacat gaaccccgag gaggcggtcc gggcgcacct
1009861 ggacgtcacc gattcgggct cgggaatgct ggtgccggtg cactggggca ccttccggct
1009921 ggccccccat ccgtggggcg agccggtcga gcggctgctc gcggcggctg aacccgagca
1009981 cgtcacggta gccgtgccgc tacccggtca gcgggtcgac ccgaccgggc ccatgagatt
1010041 gcacccatgg tggcggctgt aattccccgc agcgcccggc taatggtgct agggggcgag
1010101 ccgaggcgat caaaccaccg agtgttccgg ccgcgttggc tactatctgc ggccatgacc
1010161 aaacgagcgg caacggccgc catggtgatg ttgctgacgt taacggttgc ggatccacgc
1010221 accaggcact tggcccgccg tccgggttgc ccgatgcctc tcccaatgag aggtcagcga
1010281 tacagatccc cgctggccgc atcgacgatg ccgtggcaaa ggtcgacggc ctggtcggcg
1010341 agctgatgca gaataccggc atacccggaa tggcagtggc gatagtccat ggcggaaaga
1010401 cgttgtatgc caaagggttc ggtgtcagag acgtgggcaa aggtggtggt ccggacaaca
1010461 aggtggacgc cgacaccgtc tttcagttgg cgtcggtgtc caaatcggtc ggcgccacgg
1010521 tggtggcgca tgcggtaacc gacaacgtcg tgacctggga tacgcccgtc gtatcgaagc
1010581 tgccgtggtt tgcccttcgc gatccctacg tcaccggcca ggtaaccatt gctgacctct
1010641 actcgcatcg ctccggcctg cccgaccatg cgggcgatct gttggaggat ttgggttatg
1010701 accgtcgaca ggtactgcag cggctgaaat acctgccgct ggcaccgttt cgaatcagct
1010761 atgcctacac caactttggt gtgaccgcgg cggccgaagc ggtcgcggcc gcggccggcc
1010821 agtcctggga ggacctgtcc gacgaggtgc tctaccgccc gttggggatg gggtctacga
1010881 gttcccggtt caccgacttt ctggccaggc ccaaccatgc ggtcaaccac gtcaaggtcg
1010941 cagaccgatg ggaggcgcgc taccagcgcg atcccgacgc ccaatcacct gcgggcgggg
1011001 tgagttcgtc tcttaacgac atgacgcact ggctggccat ggtgctggcc gacggcgtgt
1011061 acaacggccg tcggatcacg tcgccggagg ccctgctccc cgtctacacg ccgcaggtga
1011121 tctctcgaca cccggtgtca ccgagagcgc gggccagctt ctatggctac ggattcaacg
1011181 tgggggtaac ctcttcggga cgcaccgagt acagccattc cggcgccttc gggctgggtg
1011241 ccgcggcgaa tttcgtggtg ctgccctccg aagacctggc catcatcgcg ctgaccaacg
1011301 ccgggcccat cggcgtgccg gagacgctga ccgccgaatt catggacttg gtgcagtacg
1011361 gccaggtacg cgaggactgg gcggccctgt acaagaaggc atttgccccg ctgaacgagc
1011421 tcgcgggctc gctggtcggc aagcaatccc cggccaaccc agcgccgagc agaccgctga
1011481 acgactacgt cggcgtgtac gccaacgact actgggggcc cgccaccgtg acctaccacg
1011541 acggccaact gcgcctgtcg ctggggccga agaaccagac gttcgatttg acgcactggg
1011601 acggcgacac tttcacgttc acgttgtcga ccgaaaacgc attgcccgga tcgatttcca
1011661 aggccacctt cgccggcgac acgttaaacc tggaatacta cgacgccgac aagctgggaa
1011721 cgtttacccg atgacccgtt cggcttcggc gacagccggt ttgaccgatg ccgaagtggc
1011781 gcaacgggtc gccgaaggca agagcaacga tatcccggaa cgggtcaccc gcaccgtcgg
1011841 gcagatcgtc cgggccaacg tattcacgcg gatcaacgcg attctgggcg ttttgctgct
1011901 catcgtcttg gcgacgggct cgttgatcaa cgggatgttc ggcctgctca tcatcgccaa
1011961 cagcgtcatc ggcatggtcc aggagatccg tgccaagcag acgctggaca aactcgcgat
1012021 catcggacag gcgaaaccgt tggtgcgcag gcaatccgga acgcgcacgc ggtcgaccaa
1012081 cgaggtggtg ctggacgaca tcatcgaact tgggcccggg gaccaggttg tcgtcgacgg
1012141 cgaggtcgtc gaggaggaaa acttggagat cgacgaatca ttgctgaccg gcgaggccga
1012201 cccgattgcc aaagacgctg gcgataccgt gatgtcgggc agtttcgtcg tctccggtgc
1012261 cggcgcctac cgcgccacca aggtcggcag cgaagcatat gcagccaaac tggccgccga
1012321 ggccagcaag ttcaccctgg tgaaatccga attgcgcaac ggcatcaaca ggattctgca
1012381 gttcatcact tacttgttgg tgccggccgg cctgctgacc atctacaccc agttgttcac
1012441 cacacacgtg ggatggcggg aatccgtgtt gcggatggtg ggcgcgctgg tgccgatggt
1012501 tcccgaaggc ctggtgctga tgacctcgat cgccttcgcc gtcggggtgg tcaggctcgg
1012561 ccagcgtcaa tgcctggtgc aagagttgcc cgccatcgag gggttggcgc gggtggacgt
1012621 ggtctgcgcc gacaagaccg gcacactgac cgaaagtggc atgcgggtct gcgaggtcga
1012681 agagctcgac ggggctggtc gacaggaaag tgtcgccgat gtgctggccg ccctggccgc
1012741 cgccgacgcc cgtcccaacg cgagcatgca ggcaatcgcc gaggcctttc actcgccgcc
1012801 gggctgggtc gtggccgcga acgcgccttt caagtcggcc accaagtgga gcggcgtctc
1012861 ctttcgcgat cacggtaact gggtgatcgg cgcgcccgac gtgctgctcg atccggcttc
1012921 ggtggcggcc agacaggccg agcggatcgg agcgcaggga ttgcgggtgc tgctgctggc
1012981 tgctggcagt gtggccgtcg accatgccca agcgccgggt caggtcaccc cggtagcgct
1013041 ggttgtgctg gagcagaagg tgcggcccga cgcccgtgaa acgctggatt attttgctgt
1013101 tcagaatgtt tcggtcaagg tgatctccgg tgacaacgcg gtgtcggttg gtgcggtcgc
1013161 cgaccggctc gggctgcatg gcgaggcgat ggatgcgcgt gcgctgccga cgggccgcga
1013221 agaactggcc gacacactgg actcttacac cagttttggc cgtgtgcggc cggaccagaa
1013281 gcgtgcgatc gtgcatgctc tgcaatcaca cgggcatacc gtggcgatga ccggcgacgg
1013341 cgtcaacgac gtgcttgccc tcaaggacgc tgatatcggt gtggcgatgg gctcgggcag
1013401 cccggcctcg cgtgcggtgg cacagatcgt gttgctgaac aaccggtttg ccacgctgcc
1013461 ccatgtggtc ggcgaggggc gtcgggtcat cggcaatatc gaacgggtcg ccaatctatt
1013521 cctgactaag acggtgtatt ccgtgttgct ggcgctgctg gtgggtattg agtgcttaat
1013581 tgccataccg ctgcggcgtg atccgctgtt gttcccgttc cagccgatcc acgtcaccat
1013641 cgcggcctgg ttcactatcg ggatcccagc gttcatcctg tccttggcgc ccaacaacga
1013701 gcgggcctat ccgggcttcg ttcggcgagt tatgacgtct gcggtgccgt tcggactagt
1013761 catcggtgtc gcgactttcg tcacctatct ggccgcttac cagggtcgct acgcctcgtg
1013821 gcaggagcag gaacaggcgt cgaccgctgc gctgatcacg ttgttgatga ccgcgttatg
1013881 ggtgctggcg gtgatcgcac gcccctatca gtggtggcga ctggcgctgg tgcttgcctc
1013941 cggactggcc tatgtggtga tcttcagcct tccgctggcg cgggagaagt tcctgctgga
1014001 tgcctcgaac ctggcgacga cgtcaatcgc gctggcggtt ggcgtggtgg gtgcggcgac
1014061 cattgaggcg atgtggtgga tccgaagcag gatgctcggt gtgaaaccga gagtgtggcg
1014121 ataaccgcga atcgccgcgc attagcgccc gcagttcggg caatccgagg gcgttgcggc
1014181 gtagtgcatc caggcggcca ttgatggctt cggtagggct ggtcttgccg cggcgccggt
1014241 cggggtgggc gtaggcggcg atcaggcgct gggagaagcc ccagcacatt ttgccgtgtg
1014301 ttgagcggtg ggtagcgcgt gcgcggggtg tgtcgtactc ggtagagcgg atctccgcgc
1014361 ggccccggtg accgcccgtg agctgttgga tggttggtgg tgcatatcgt cggtctgtcg
1014421 atcgagacca cagcaccgac cgactccgcg attactccca tcatggtccg ggaaatcaac
1014481 atcggtgaga tccccctagg cctcaggctg ggcagcgaca ccacactgct cgacgccgct
1014541 ctcgcgggtg ggtaacaccg gcagccagct ttcgggcttt tcccgaccgg ctctaagggc
1014601 tggttgcagt caaccgcacc gcgacaagta gggttcacca gaggatactg gggccaagct
1014661 cgtggcaaga aacggtacgc atgggaatcc tggacaaggt aaagaacctg ctgtcgcaga
1014721 acgccgacaa ggtcgagacg gtgatcaaca aagcgggcga attcgtcgac gagcagacgc
1014781 aaggcaatta ttctgacgcc atccacaagc tgcatgacgc ggccagcaac gtcgtcggca
1014841 tgagcgacca gcagagctag cacgcatggc gaaactgtcc ggatccatcg acgtaccgct
1014901 gccaccggag gaagcctgga tgcacgcctc cgatctgact cgttaccgag agtggctgac
1014961 catccacaag gtatggcgca gcaagttgcc cgaagtgctc gagaagggca cggtcgtcga
1015021 gtcgtatgtc gaggtcaagg gcatgcccaa ccggatcaag tggacgatcg tgcggtacaa
1015081 acccccggag ggcatgacgc tcaacggcga cggtgtgggt ggtgtcaaag tcaagctgat
1015141 cgctaaggta gcgccgaaag agcacggctc cgtcgtcagc ttcgatgtgc acctcggcgg
1015201 cccggccctg ctcgggccga tcggcatgat cgtcgccgct gcattgcgag ccgacatccg
1015261 cgaatcgctg cagaacttcg tcacggtgtt tgccggctga ccggcgaacg tgatcggtgt
1015321 cgatgagttt cagactccgg ggcggtcggt acctgtgaac cctgatccag ggcccgacac
1015381 agactaggag gtcatccgtg cctactcgta gtagcgcgcc gctgggcgca ccctgctgga
1015441 tcgacttgac gacttcggac gtcgaccgtg cccaagattt ctacggcacg gtgttcggct
1015501 gggcgttcga gtccgcggga cccgactacg gcggatacat caatgccgcc aagggcggtc
1015561 acccggtcgc cggcctgatg gccaatcggc ccgagtttca gtctcccgac ggctgggcca
1015621 cctactttca taccgtcgac atcggtgcga ccgtggccaa gttggctgcc gcgggcggtt
1015681 cgtcgtgcct ggacccgatg gaagtacccg gcaagggctt catgagcctg gcggtcgatc
1015741 cgtcgggtgc ggccttcggc ctgtggcagc cgctgcagca ccacggcttc gaggtgatcg
1015801 gtgaagccgg ctcgcccgtc tggcatcagc tgacgacgcg cgactaccgt tccgtcatag
1015861 acttctaccg ccaggtcttc gggtggcgca ccgaacagat ttccgacact gacgaattct
1015921 gctacaccac agcatggttc gacgatcagc aattgctcgg tgtgatggac ggcagctcct
1015981 gtctccccga aggcgttccg tcgaattgga ccatattctt tggtgccgag gacgttgacg
1016041 agacgttgcg ggtgatctgc gacaacggcg gaagtgtggt gcgggccgcc gagaacaccc
1016101 cgtatggccg attggccgcg gcagccgacc cgatgggcgt tgtcttcaat ttgtcgtctc
1016161 tgcaggcgta atggcgaatc gggctgccgc gtggcgcgcg gcgacccgcc catgcgcagt
1016221 attagtgtca caaccatgac gcgccgcctg cgccctggtt ggctcgtggc actttccgcc
1016281 gcggtcatcg cggccagcac ctggatgcct tggctgacga cgaccgtcgg cggtggaggc
1016341 tgggtcaacg ccattggggg cacacacggc agcctggagc tcccgcacgg gttcggcccg
1016401 ggtcagctca tcgtcttgct ttcctcgacg ctgctggtgg ttggcgcgat ggcgggacgc
1016461 ggcctgtcgg tgaagctttc ctcgattgcc gcgctggtcg tctcgctgct catcgtggca
1016521 ctcacggtgt ggtactacaa gctcaacgtc aacccacccg tgtcagccga atacgggctg
1016581 tacttcggtg ccgccggcgg ggtgtgcgcg gtgggttgct cgttgtgggc tgcggtgtcg
1016641 gccgcttcgc ctgggcgtcg tcgccatcgt gaagtggtgc ggtagaacat ttcagcccgg
1016701 cggaactcgt gttttccccg tgcggggctg gctcccgatt gggtagcccc gtacacgaaa
1016761 ggcgcaaaca caacctcgcg gccatccggg tcgcgataga tgacggctcc ggtagcttct
1016821 caaagggggc gttgttccac cggctgggtc gccacctctt gcaggccagt aagtgcggct
1016881 tgctgccccc gcttgtccga gcaataccgg cacagctgtt cgtgatggtc tgtttcgacg
1016941 atttccagcg tcaggctcga gctgggaagg ccgaatatcg cgccgttgct tccgtagctt
1017001 tcggcgaagg tctggtcgag cattcccacc agatcacggt agaaccgcac tgtctcttcc
1017061 aagttcgacg ggcggggccg attgacgcca atccctcggg ccagtgcgtt gttcggcggc
1017121 gcttttcgtt gtccaccgct actccgtttc gccgaggctg cacttctgca ggccgctact
1017181 cgcagttttg ctgcggattt tccggctcgg tgcaattcat agcccaacgg cagccgccgg
1017241 cgactctgcg tgatcccagc gacgcaactc ggcgcccggc acccacgccg aatgcgtgcc
1017301 gctggaaata cgttccggca gtgcaagctt gcatatcggg ccatcgccgg ggcgcgccgc
1017361 gtcgaaaacc aggcaatacg atgcgtcgtc gttcatgtcg gtggtgaggg tgaccagata
1017421 gccgtcgtcc tcggcgctgc tgcccacccg tggagccatc gcggtctcac ttccgtagac
1017481 gccgtcaccg aacgagtaac actcgtggtt gccggtgagc agatcgtgct taaccagtcc
1017541 gtcgaacagg aaccaactcg gtttgccggt agcggcatag gtgtaacggt agctgctggc
1017601 cgcgtaatcg gcgttgatgg ttccgaactc ggtgatggac tcggacagtt gctcctcgtg
1017661 gactgccccg gtcaccatat tgagccgcca ccgatgtagc cgggactgca gccgatccag
1017721 agccaggaac cgaaacagct tctcccactt cgttcctccg gtgtcaagtg gctgcggatc
1017781 gccttcgtag aagccgtcga gcacgatctc gtcgccctgc tcgtaggcgt tggtgaagtg
1017841 caacacgaac gttggatcgg cttcgaacca gcgaatgtcg ttgcctcggc gagcaacaac
1017901 cgcaaaccga gatggaatct ccggatagaa gcgtggtagg tgcacgtcgc gctcgagcag
1017961 cctgggatcc cagaacagtg gaaaatcgtt gaggattacg taattttcgg tgaacgccat
1018021 gtcatgcggt agccgcggcc cgggcagcgg aacatcgaca tagtgcacaa gctcattgtt
1018081 ctggtcgaca acgccgtagc gcatatacgg ctcttgcttg ctgtagttga agaacaacag
1018141 ttcgccggtc ttgttgtcta ccttcggatg tgccgacacg ccccagtcga acggaaacct
1018201 tccgtgccag ctctccttgc cgagcgtatt ggccgagtac gggtcgatcc gatacagatc
1018261 gccgcactgg tagaagctag tcagcgcgat acctcggtgg acgatgacgt cggtgctcga
1018321 cgcgtccttc atgaggccac gagcgcccca gccgtgttcc cgcttggcca gttgcaccgg
1018381 ttctgccaga cccggccaca gcggcccgcc ggcctcgttc tcggccaaga atccatcggt
1018441 gcgaataaat cggttgcggt agaaggcttt tccatcacgg aagccgacga catggatcat
1018501 gccgtcgcca tcgaaggggt ggtaggtcgc gaatgccggg tgtagcgggt tctcggtgtt
1018561 gcgcaggtag atgccgtcca ggtcggcggg gacttcgcct gtcacggtgg tcaggtcgtc
1018621 ggcatcccat tcggtggtct gtggtcgcca cggaccggtg cgataggggt ggtcgtcgtc
1018681 ttcgggaagg gtcgacaagt acttgccgac aatcgtgatg tccatttcac gatcctcgtg
1018741 tggtgctgac aacgaaactg accgtggtgg ccgtgctgcc accgaaattc agcgtgccga
1018801 acgcttcggc gttctcgacc tgatagtcac cggcaatgcc gctcacctgt ttggccgcgt
1018861 cgagcagcat ccgcacaccg gaagccccga ccggatgtcc gccaccgatc agtcctccgc
1018921 tggggttgat gggtagccgc ccgccgatct cgatctctcc gttctcgatg gccttccaag
1018981 attccccggg gccggtcaac ccgatgtgat cgatggccag gtattcgctg ggggtgaagc
1019041 agtcgtgcac ctcgatcccg tccagatcgt cgagggtcac ccgggcgcgg cgcagggcgt
1019101 ccagcactgt ggcccgcacg tgcggcagta ggtagggggc cgagtcgccc tgggcgacgc
1019161 ggtccagttt ctgccgcaga cccaacccga cggtgcgatg tccccagccg tcgatgcggc
1019221 cgatcgggcg cgcgtcgcga tggtcgcgca gataggcatc gctgaccagg accaatcccg
1019281 cgccgccgtc ggtcatctgg ctgcaatcaa accgtcgcag ccggccttcg gtaagagggt
1019341 tggtcgcgtc gtcgtcggtg atcgggtcgg ggatcgtcca gccgcgggtc tgcgcgttgg
1019401 ggttgcggcg cgcgttggcg aagttgagtt gagcgatggc ccgcaggtga gtgtcatcca
1019461 aaccgtatcg ccggtcgtat tcgtcggcga cctgagcgaa catcgacggc cataagtagc
1019521 gggcctcggc tccttcgtgc ccggtccagg ccgcggcact cagatgctcg gccgcggtgt
1019581 cgccgggcac ggtcttctcc agctctaggc ccacgacgag cgcgacacgg tacgcgcctg
1019641 atcgcaggtc ggccatcgcc gcgagcgtcg ccacgctgcc ggatgcgcac gcggcctcgt
1019701 gccgggtggc cggcgtgtcc cagagatcgt cgcagacagt ggccggcatc gcgccgaggt
1019761 ggccttgacg ggcgaacatc tcgccgaagg cgttcgcgac gtggacgact cccgcagcgg
1019821 ctaggtcggc ggcgtccacc ttggccgcgg tgagcgtgcc gtcgacgacc tccctagtca
1019881 ggtcggcgaa gtcgcggttc tctttgctga ggttgcgagc aaaatcgctc tgatagccgc
1019941 cgagaatcca gacaccgtcg tccatagccg tacgctacta caagcggtgt gaacggcccg
1020001 tcggatagcc acgctcacca ggcattttcc gcgcggcgac gaacggttgc cggactttta
1020061 ccgcgggggg tttccgggcg gcggctgctc tctaatcaca actaccgggg gtttgcggcc
1020121 gtcctcttgg ccgtcagtgc tggtgccgct acgggtgccg ccaccgcccg tcgtgccgcg
1020181 tgcggccagg ctcgccaaag ccatcccgct gagcaggcct gccggcatcc cgtttagggc
1020241 cgtcgggtcg gcgccggcgc tggagctgaa ggtgggtgtt gcctgaacgg cgagctggat
1020301 ctccggggcg gccgtggtcc agctgtgcgg caccgacaac gctccgacta atgctgcgtg
1020361 gccgacgccc gcggacaccg gcgccgcgcc cccgaagggg ccccagtgcg gctccggctc
1020421 gtcggtcgcc gaactcagtg gatggccctg cgtcggtccc agcccgccgg cgttcccgta
1020481 taggccgatg tgccagggtc tggccgtgtt cgtgatcgcg agcgcaatgc tgccggtcgc
1020541 gatggatgca atgtagagcg cgatcacgtc caattcccct atcggggtgg ggatcactat
1020601 cggctgagcg gatccgactt gcgggttgag ggtcgacgcg atccccaaca gtcccgatgt
1020661 cagcggatca gcgttggcgg ccaatgcgga cagaatgtcg ctcaggatcc ccgggggcag
1020721 ctgggccagt gtcgcctgtg catccgcaac ggcgcccgca ccggcggctt gggtcgccgc
1020781 ggctgcggcc gcgggcccgg ccgggccggt gccttgcacg ggtggagtga acggcggcaa
1020841 cgccgacgcg gccgcagatg ccccctcata gctgtacatc acggcagcgt cttgggccca
1020901 catttcggca tactcggcct gggtagccgc gatcgccgca ctgttttgcc ccagaatgtt
1020961 cgccgcgacc agcgacatca accggctgcg gttggccgcg acgagggatg gtggcaccgt
1021021 catcgcgaac gccgtcccaa acgcttccgc cgctgccctc gcctgtgtgg ccgtctcctt
1021081 cgccagcgcc gccgtggcgg ccagccaccc cacatacggc gttgccgcgg ccgccatcgc
1021141 ggccgccgcc ggccccatcc acggctcaac gatcagcgtc gacaccaccg atccatacga
1021201 gaccgcggcg gaagtcaact ccgcggccac accgtcccag gcggccgcgg cggctagcat
1021261 cgactccggc cccggaccgg aatacattcg gcttgaattc acttccggag gtaaaagccc
1021321 gaaatccatt gccagcaacc tccttaaccg gtcgcgacca cattgacggc ctcggtggtc
1021381 gcatacgcat cggcggtggc cgccgggagg gccacgaaca tgccatggac cagcgcggcc
1021441 ggcttactca ccactcggta gtgcttggtg tgcgcggtga accgggccgc cgtcaggacc
1021501 gacacgtcat tggcagcagg gggtaacacc cccgtcgtcg gggcacagac ggctgtgttc
1021561 cgagcactca cggcggtacc gatcgtcggc aagtcccccg tcgcggctgc caagaccacc
1021621 ggctggatgg tcacaaaaga catcggatac cacctgacgc ggatcgcttc atctgatcgg
1021681 tcgacatctt ctacataacc acggaaatgt ctgctttata acggaattag actactttgt
1021741 gttgtctggc gttgctctgc accgacggca tgggtaaacg tctgagatgc gggtgtcggc
1021801 ggtagctgaa aaaccgtgct gacaaccatg attcgccatt cccgaacgac ctgcgaactt
1021861 tgtcgcctag cgtaacgccg tggcgagatt tggctcgatt gttcgcagtg gcgttacgct
1021921 cgccacgcgt gagcctggat caggcaaacg cggctccacc tggccatttg ctgtccgaga
1021981 cggtagttac tcagcatggt gcacaggtct gtgcttgtct ggttgatggt gatttggcgt
1022041 tgcggtggcc gtgatgagga cgcggtgaga aacggagctt gaagatatgt cagcgaaaga
1022101 acgcggtgac cagaacgccg tcgtcgacgc cctgcggagt attcagcccg cagtcttcat
1022161 tccggcttca gtggtcatcg tcgccatgat cgtcgtttcc gtggtgtact cgagcgtcgc
1022221 cgagaatgcg ttcgttcggc tgaactccgc gatcaccggc ggcgtcgggt ggtggtacat
1022281 cctggttgcc accgggtttg tggtattcgc gctgtactgc ggcatttccc ggattggcac
1022341 tatccggctg ggccgcgacg atgagctccc cgagttcagc ttctgggcat ggctggcaat
1022401 gctgtttagt gccggtatgg gtatcggcct ggtcttctac ggggtggccg agccgctcag
1022461 ccactacctg cggccaccgc ggtcacgcgg cgtgcccgcg cttactgatg cggcggctaa
1022521 ccaggcgatg gcgctgacag tgttccactg gggcctgcac gcctgggcaa tttatgtcgt
1022581 ggttggcctc ggtatggcgt acatgaccta tcggcggggt cgccccttgt cggtgcgctg
1022641 gctgctggag ccggtcgtgg gtcggggccg tgtagagggc gccttggggc acgcggtgga
1022701 cgtcatcgcc attgtcggaa cactctttgg tgtcgccacg tcactgggct tcggtatcac
1022761 tcagatcgcc tccggcctgg aatatctcgg ctggatccgg gtggacaact ggtggatggt
1022821 cggcatgatc gccgccatca ccgccactgc gacggcgtcg gtggtcagtg gggtcagcaa
1022881 gggtttgaag tggctgtcga acatcaatat ggcgctggcc gccgcattgg ccctgttcgt
1022941 gttgttgctc gggccgacac ttttcttgct gcagtcgtgg gtgcaaaatt tgggaggcta
1023001 cgtccagtcg cttccgcaat tcatgctgcg caccgcgccg ttctcgcacg acggctggct
1023061 cggcgactgg actatcttct actggggttg gtggatcagc tgggctccgt ttgtcgggat
1023121 gttcatcgcg cggatttcgc ggggacggac gatccgggag ttcatcgggg cggtgctgct
1023181 cgttcccacc gtgatcgcct cgctatggtt tacgatcttc ggtgactcgg cgttgttgcg
1023241 gcaacgcaac aacggcgaca tgctcgtcaa cggggcggta gacaccaaca catcgctttt
1023301 ccgattgctg gacggtttgc ctatcggggc tattaccagc gttcttgctg tgctggtgat
1023361 cgtgttcttc ttcgttacgt cgtcggactc cggttcgttg gtcatcgaca tcttgtcagc
1023421 gggtggtgag ctggacccgc ccaagctgac cagggtctac tgggcggtgt tggagggggt
1023481 agccgcggcc gttttgctcc tgatcggagg tgctgggtca ctgaccgcgt tgcggacggc
1023541 cgctattgcc acggccctgc cgttctcaat cgtcatggtg gtggcgtgct atgcgatgac
1023601 caaagcgttc cacttcgacc tggccgccac acctaggctg ctgcacgtca ccgtgcctga
1023661 cgtggttgcg gcaggaaacc ggcgacgcca cgatatctcg gcgacgctgt cggggctcat
1023721 tgccgtccgt gatgtcgata gcggcacata tatagtccac cccgacaccg gcgctctcac
1023781 cgtcactgca ccaccagatc cgttggacga tcatgttttt gagtctgatc ggcacgtaac
1023841 gcgaagaaac acaacatcat cgagatgatg tgttatcgac ctgccgggtc gccgctgcct
1023901 ggaccggagc cggctacttc cggtaaacgc gcaccgctgg atgaatcgcc gcggcatgag
1023961 aagctcgacg gtggtgccgg gatcgtcgcg cacgatgtca tgctccaggg tgctggtcag
1024021 ccgatggcct ttggtgtgcc actgaccggg tcgatctccg cggccggcga ccacgccacg
1024081 gtcgcgtcca tagcacaggt cgcgcggcgc gcgacggcgt gacccgacat caagtcctta
1024141 tcggaggagc ttggcccctc gcgttggtcc gcggcaggct cggtcggcaa atcctcaaat
1024201 cggccccaag ttgcaccgag cgggagcggc ggtgacggcc aacgtgtggt gtcgtgcggg
1024261 cggcattcgg atggcgccac ggccggtcat cccggtggct acgcagcagc gcctgcggcg
1024321 gcaggcggat cgccagagcc tgggtagtag cggcttgcca gcgttgaatt gtacgcctat
1024381 caggcacaca attgatgtca tggctaccaa gcctgagcgg aagaccgagc gtcttgcagc
1024441 gcgcctgacc cctgagcagg acgcgctgat tcgtcgtgct gccgaggccg aggggactga
1024501 cctcaccaat ttcacggtta cagcggcgtt ggcgcacgcg cgcgacgtgc tggccgaccg
1024561 ccggctcttc gtactcaccg atgccgcgtg gactgagttc ctcgccgcgc tggaccggcc
1024621 cgtctcacac aagcctcggt tggagaagct gttcgccgcg cggtccattt tcgacaccga
1024681 ggggtgagcg gctacagcgc gccgcgacgt atcagcgacg ccgatgacgt cacgagcttc
1024741 agcagcggcg agcccagtct ggacgattac ttgcgcaagc gggcgttggc caaccatgtg
1024801 cagggagggt cgcgctgttt cgtgacgtgc cgtgacggtc gggtagtcgg cttctatgcg
1024861 ctagcgtcag ggtcggtcgc acacgctgat gctccgggac gggtgcgccg caatatgcct
1024921 gaccccgtgc cggtgatcct gctgtcgcgg ttggcggttg atcgcaaaga acagggcagg
1024981 ggcctgggca gtcatctgct gcgtgatgcg atcggtcgct gtgtccaggc tgcggactcg
1025041 atcgggctgc gggcgattct tgttcatgcg ttgcacgatg aggcccgcgc gttctacgtc
1025101 cactttgact tcgagatctc gccgaccgat ccgctgcacc taatgctgtt gatgaaagac
1025161 gctcgcgcgc taattggcga ctgatgctac gcgattgact atcgagagcc aggctacgtc
1025221 atctgatacc aaccaatcac cgaccacagc accgaccaga acaagccacg accactcggc
1025281 tgacacctga aaaccatggc tgaactgcgc aaacacagag tgcccccggc aggattcgaa
1025341 cctgcgacac cggctttagg agagccgtgc tctatcccct gagctacgag ggcggggacg
1025401 cctttgaata cctgactaaa acctagccgt tcgccgcgcc ggccgggact gtccgatatt
1025461 cggtgtaagt ggcgtttctc gggatttttc tttcggtcag cgttcttcgg cggctggcat
1025521 gcgatcggcg aacgtgatcg ccagggcgtt gagcgctggc ttccagcgta cggcccactt
1025581 ggtttgcccg gtgcccttgg gatccaggga gcgggtgacc aggtagagcg tcttgagtgc
1025641 tgactgttcg ttcgggaagt gtccacgtgc ccgcaccgcc cgccggtagc gcgcattgag
1025701 actttcaatt gcgttggtag aacacgggac tcgccgtatt tcgacatcat agtccaggaa
1025761 cggaatgaac tcttcccacg cgctgtccca cagccgtgtg atcgccgggt aaggcttacc
1025821 ccatttctcg gcgaactcct cgtagcgcaa cctggcctca gcggcactgg ctgcggtgta
1025881 gatcggcttg aggtcgacgc tgatcttgtc ccagtacttg cgggaggcat accggaaagt
1025941 gttgcggatc agatggatga tgcaggtctg caccgtggcc aacgggaacg ccgcggacac
1026001 gctgtcgggc aaccctttga ggccgtcgca gaccaggaag aagatgtctt tgaccccacg
1026061 attgcgcagg tcggtgagca ctgccagcca aaatttggct gactcaccgt cgccttcgcc
1026121 ggcccacatc cccaggatgt ccttgtggcc gtcgaggtcg acgccgatcg cggcgtagac
1026181 cggccggttg cggacctgcc cgtcgcggat cttgaccatg atcgcgtcga tgaacaccgc
1026241 ggcgtagacc ttctccagcg gcctggacca ccacgcctgc atctcctcga tgacccggtc
1026301 ggtgatccgc gagatggtgt ccttggacac cgacaccccg taaacgtcgg cgaagtgagc
1026361 cgcgatctcg ccggtggtca ggcctttggc gtacagcgac aacaccaccc ggtccacatc
1026421 ggtgacccgg cgcttacgtt tgcccacgat caccggctcg aaggtgccgt tgcggtcacg
1026481 gggcaccgca atctcgacct gtccgcacgc atcggttatc accttcttgt tacgagatcc
1026541 gttgcgtgag tttccacttc cacgcccggc tgcggcgtgc ctgtcgtagc cgaggtgttc
1026601 ggtcatctcc tcttgcaggg cggcttcgag caccgtcttg gtcagcgcct tgagcaaccc
1026661 gtcagggccg gtcaatgcga ccccctcagc gcgtgcctgg cgtaccagat cacccaccag
1026721 cgcccgctcg gcaccggaga gctcacgggc cgcaacggcc gcctcatcca cgtcctggcc
1026781 ggcgtgagcc ggctctatca cctgagcagc atccatgccc ttgagtgtgt ttggtcatag
1026841 cagtgattcc ttctgcccca cgccgggggc ggtcagaacc acttacaccg aatcagcgat
1026901 agacccctcc ggcggcgggg gggttggcgg tgtttgtggc gtccggtcgt cggggtgcgg
1026961 cgggtgtgag tgtagcgggc gcaacgaggg ccacctgacg ctcgggcgtg tgtggtgggc
1027021 gcttgtcggc caacgctctg gggttcagag ctgttgcgtg ttgagtgtgt tttagtgtgc
1027081 gttagtgtgt tctaattggc ggcgtgaatc tggcggattg ggcggagtcg gtgggggtga
1027141 atcgacatac cgcttatcgc tggtttcggg aggggacgtt gccggtgccc gcggagcggg
1027201 ttggccggtt gatcctggtc aagacggccg cctcggcgtc ggccgcagcg gcgggagtgg
1027261 tgctgtatgc gcgggtgtca agccatgata ggcgttcgga tctggatcgg caggtcgcgc
1027321 gtctaaccgc gtgggccacc gagcgtgact tgggggtggg gcaagtggtg tgcgaggtcg
1027381 gttccggcct gaacggcaag cgacccaagc tgcggcgcat cttgtcggac cccgatgcga
1027441 gagtgatcgt tgtggagcat cgggatcggc tggcgcgttt cggggtggag cacctcgagg
1027501 cggcgctgtc tgctcagggc cggcggattg tggtcgccga tcctggtgag acgaccgatg
1027561 atctggtgtg tgacatgatc gaggtcttga ccggtatgtg cgcgcggctg tacgggcgtc
1027621 gcggtgcgcg caaccgggcg atgcgtgcgg tcacggaggc caagcgtgag ccgggggcgg
1027681 ggtgatgatc gtcaggatgc gtagctgcgc tcaggccgcg aaggtggccg aggccaccgg
1027741 tggtgtgcag ctggcgggca agccgaaacc cgatgggaca ccgacgttct cccggtatgt
1027801 ggagatcggc gtggattttg aggcgcaccg gccggtggtg gagtcggttt cggtgctgtt
1027861 cgagctttat gacggcgacg ccaacagtta tgccgcgacc ggggggccgg gtgcccaact
1027921 gccgtcgggc tggatggtca cggcggcgaa attcgaggtc gagtggcccg ccgacccgca
1027981 gcgggcgggt ttggtgcgtt cacatttcgg cgcccgccgc aaagctttca actggggcct
1028041 ggcccaggtg aaggccgacc tcgacgccaa agccgctgat ccggcacatg agtcggtgga
1028101 ctgggacttg aagtcgctgc gatgggcgtg gaaccgagcc aaagatgacg tggcgccgtg
1028161 gtgggccgag aattccaagg agtgctactc gtcggggttg gccgatctgg cccagggcct
1028221 ggctaattgg aaagctggca agaacgggac ccgcaaaggc cggcgggtgg gcttcccgcg
1028281 attcaaatcc gggcggcgtg atcctggcag ggtgcggttc accaccggca ccatgcgcat
1028341 agaggatgac cggcgcacga tcacggtccc ggtgatcggg ccgctgcggg ccaaggagaa
1028401 cacccgccgg gtgcaacgcc acctcgtgag cgggcgcgcg cagatcctga acatgacctt
1028461 gtcgcagcgg tggggccggt tattcgtggc ggtctgctac gcgctgcgca ccccgaccac
1028521 cagatcaccg ctcacccagc cgactgtgcg cgccggaatg gacctgggag tccggaccct
1028581 ggccacggtc gccaccctcg acaccgccac cggcgagcag accatcatcg aatacccaaa
1028641 cccggccccg ctcaaggcga cactcgtcgc ccgtcgcagg gccggccgag aactttcccg
1028701 ccgcatcccc ggctcccatg ggcatcgggc agtgaaagcc aagctggccc gcctggatcg
1028761 ccggtgcgtg cacctacggc gggaagcagc ccaccagctc accaccgagt tggcgggcac
1028821 ctatggccag gtcgtgatcg aagacctcga cgtggccgcg atgaaacgca gcatgcgccg
1028881 gcgggcgttt cgccgatcgg tctccgatgc cgcaatgggt ttggtcgcgc cgcagctggc
1028941 ttacaaaacg gccaagtgca gcggcgtgct gacggtggcg gaccgctggt ttgcctccag
1029001 ccaaatccac cacggctgca ccagccccga cggcacaccg tgccggctgc aaggcaaggg
1029061 ccgcatcgac aaacacctgc tctgccctgt aacgggcgag gtagtcgacc gcgacagaaa
1029121 cgctgctttg aatctccgtg actggccgga taacgccagt cgtggtccag tcgggaccac
1029181 ggccccatcg gcacccgggc caaccaccac ggttggtaca ggccatggcg cggacaccgg
1029241 atcatccggc gccggcggag catccgtaag accccgccca cgcagggccg gacgcggcga
1029301 ggccaaaacc caaaccccgc aaggggacgc cgcatgagag tgcaactaaa acacactcaa
1029361 cggcaacggt gtcgtcggga tgccagcgcc gcccacgcat cttcacttga tcgagatcga
1029421 tcaggtgatc ggccgctcat tggcggccgc ggcatcatgc agatggttga cgagctgcgt
1029481 gcggccgctt ccggtccaaa atcgccagac agctaccagg aacgggccgc agttaccagg
1029541 ccctgtacca gggtagcggt gaccggtgac atgccgccga cgccggggag ggtactgcgt
1029601 gggcccagac cccttacccg aatcgatagt tccagctggg tcccgccgtc gcggacccgg
1029661 ttgaccggat tgtctggatg caggccgcgg agctcctccg ggatggcggc cagatcggtg
1029721 actacccgat agccgggcag ctggatgtgc cgcgcgagat gggcggcaag cgcgcggttg
1029781 cggcccccgg ccaacagctg ggtgctgcgc ccgatgcggt cgtagccgtg cagcgacacg
1029841 gcgacgtcaa cgtggtcaag gaattcggcg aggcgcgccg attccgcagg gtcgaaccgg
1029901 gccgacggca ggtggtgcgg gtagttgtcc ggatgacgca gcaggtacac cgaagcgccc
1029961 gcagcctcgg cggagcgttc ggcgatcagg tcggtcacct gctccaggcc gcccccgtgg
1030021 atggcgagga agccgaagcg ggaccgcagc tggctcgtct cgatgacgcc gggctggctt
1030081 agcaactccg aaagtgattg tggcgcaggc ccagatctcg atgacggtaa cactggcagg
1030141 ggccaccgcg cggggtccca gcggtgcaga tagtcgatcc agcgttgcgg cagcccgtgg
1030201 tgtcgagcgc cgtcgatgac gcgcggtaga tagcccggcc gcggccggcc cggcatcacc
1030261 cggtggtcaa tgtagaccca ggccggcaac gctgtgtcgt cggtgtgcac ggtcaaccgt
1030321 tcgcgccggt agcgcaccgg cacgccttcg gcgctgtcca acctgaccag gtcgcgctcg
1030381 gagagctgcc atagcacgcc atgcaccttg tttccggcga agggttcgac ggtggccacg
1030441 ccgcgctggt tgatcagcca gttgtgatcg ctgagcactg ccggccgcgg agcaccggcg
1030501 tcgggacagc gcgacgccat ctggtgggcg cacaggttgg acccgtaggc gaagtaggga
1030561 tgccggcggt ccggcattca gccggtcacc gtgagataga tcagcatcac gttgagcaga
1030621 ctaaccatca ccgcgaccac ccagccaacc caagtcgtgg cgcgatggtt ggtgtcgccg
1030681 cccatcaccg cggggctgcc ggtgagtttg accagtggaa gtaccgcaaa cggaataccg
1030741 aacgacagca ccacctgtga gagcaccaat gtgcgggtgg ggtcgaagcc cagcgtaagt
1030801 atcgccaacg cggggcccag cgtgattagg cggcgcacca gcatgggaac gctccagtgc
1030861 agcagcccct gcatgatcat cgcgccggcg taagcaccca ccgacgacga cgccaagccg
1030921 gacgccagca acccgaccgc gaagagcacc gcgatcgtcg cccccaaggt gtcgtggacg
1030981 gcgtggtagg cgccttcgat cgaggcggtg tccccacggc cccgcatgtt cagcgcggca
1031041 accagcagca tcgcggcgtt taccccgccg gctatcagca tcgccaggcc gacatcccag
1031101 cgggtgacgc gcagcagccg gcgccgctga gggcccggat cgggatgccc gtgccggtcg
1031161 cgcgcgagac ctgaatgcag gtagacggcg tgcggcatga cggtcgcccc catgatcgcc
1031221 gcggccaaaa gaacgctctc ggttccctga aagcgcggtg ccaaaccgcc gaggaccgca
1031281 ttggggggtg gtgtcacgac gaagaaactg gcggtgaagc cgatggcaat caccagcagc
1031341 aaggcggtga tgacgcgctc gaacaaacgt tgaccgcgcc gatcctggat cgtcagcagc
1031401 agcagcgaga ccaccccggt gatgatcccg ccgatcggca gcggcaggtt gaacatgatc
1031461 cgcaatgcga tagctccgcc gatcacttcg gccacatcgg ttgccatcgc gacgatctcg
1031521 gcctgtgccc agtaggccag ccgggccggg cgtcccattc gcttgccgat cgcttccggc
1031581 agtgagcgtc cggtcaccag cccgagcttt gccgacaggt actgcaccag ggcggccatc
1031641 acgttggcgg cgacgatcac ccataacaac aggtagccga actgggcgcc ggagctgacg
1031701 ttggctgcca cgttcccggg gtcgacgtag gcgatggccg cgacaaaggc tggcccgagc
1031761 agataccagc tcgtcttcag ggaagtccgg gtgtcctggg ccaactcacc gactttcgat
1031821 ccacgcgaac aaagatgcga gagtaaccga aattcgcccg ccaccaacca ccgggctact
1031881 cgggacctcc gctggctatc ggtagtcggg gttggcgaag tccggccggc agccggcgtc
1031941 ccacttggtg cgttgattgc cgtaggccgg gatgccgccg gcgacccgca acatctgcgc
1032001 gatgtgcatc agattgaacg tcatgaatgt ggtgttgcgg ttggtgaagt cgttctctgg
1032061 accgccggat ccggggtcga gatacgacgg tcccggcccc gcttcaccga tccagccggc
1032121 atccgcttgc ggcgggatgg tgtatcccag gtgttgcagg ctatagagca cattcatcgc
1032181 gcaatgcttg acgccgtcct cgtttccggt aatgaggcaa ccaccggcgc ggccgtagta
1032241 ggcgtactgt ccatcctcgt tgagcaggct cgagcatgcg tacaggcgct cgataacccg
1032301 tttcatcacc gagctgttgt cgcccagcca gatcggcccg cacagcacca ggatgtgcgc
1032361 atcgaggaca cgccgataca gggcgggcca ttcgtcggtc gcccaaccgt gttcggtcat
1032421 gtccggccat acgccggtcg ctatgtcatg gtcaactgcg cgcagagtgt cgacctggac
1032481 gccatgctca cgcatgatcc ccgagctgcg ctcaatgagc ccgtcggtat ggctgagctc
1032541 tggcgagcgc ttcagtgtcg cgttgatgaa cagcgcacgc agcccgtcga atcggggtgg
1032601 ggccgcggcg ttctggtcag aggttgtggt catacgtcat acccacctgc ctgtcatcgt
1032661 cgtgccgggt tgccgctggg cggcggtgct ggtgccaaga aatgaccgat caggcagcag
1032721 cgtaccgccc ttcaccggtg atcaggggta ggtcgagggt tgtccggata cccggttcgg
1032781 cggccaccac tgcagggatc gcgttgacga tgcgcatcgc ggtggcgacc agtccggcgt
1032841 ggttgtggtc cccgtggcgg ctgctcaggc agatgtccat ggcgtagcag ggctcgccgg
1032901 agatttcgat gcggtacgag ccgcccggct gggcgggctg cggccactcg ggacataggt
1032961 ccgcgcgcaa ccgggtcacg tgttccagga ctaccgctgg cacgccgtcg accaggccga
1033021 gcacctcgaa gcgcagggcg gcggcgctgc ccttaggaat atggcccgat gcaatgttga
1033081 aggcctccgg cgccggctcc cggacataca tttcctcgac cccgtcaagt gaaatgccaa
1033141 ggcccgcagc aagttgtcgg accactgatc cccaggccag gctgagcaca cctggctgca
1033201 gcagcatcgg gatctggtcc atcggcttac cgaagcccat cacgtcgaac atgactacgg
1033261 cgctgtcata ggtggcgtag tcgacgatct ccatgcagcg tatctgctcg atgctttcac
1033321 aggtgccggc caacgccatc ggcaacaggt cgttggcgaa acccggatcg atgccgttca
1033381 cgtacagact tgaatttcct gcgcgcgcag cgtcttgcaa aggcttgatg atctcgtcgg
1033441 ggatcacctg ccacggatat tgcaagaaca ccgggccgct gccgacgata ttgatccctg
1033501 ccgccaagat tcggcggtag tcttccagcg cctcgggcag ccgattgtcg gccatcgcgt
1033561 tgtagacggc gcaccgcggc ccggtggcga gcacggcgtt cagatcggtg ctggcccgca
1033621 cacccgtcga atccgccagc ccggcaagct ctgccgcatc cttgccggct ttggcgtccg
1033681 atgacaccca gacaccggtg agctcgaact ccgggtcggc gatgagcgca cgcaacgagt
1033741 gcacgccaac gttgccggtg cccaattgaa cgacgggtat ggccatggcg ggctccttag
1033801 cggtaggggt cagactgcga ctgctcgcgc atcatcggtt cacaggtccg gaatgggaag
1033861 gtcgagattg gggaaggtga gtccgccgtc gacctccaac gtcttgccgg tcaggaagct
1033921 gcccgccgga gaggccaaat acactgccgc agctgcaatg tcgacggggt caccgagccg
1033981 gcgcagtggt gtcgcctgct ccatcggcgc acgcagctcg tcgttggcgg ctaccacctc
1034041 cagcgccgag gtcaggatgg aacccggcgc gatcgcattg acccggacgc gtgggcacag
1034101 gtccagcgcc gccagccggg tgtagtgggc cagtgcggcc ttggcggtgc cgtaggcggc
1034161 gaaaccccgc gccgccagcc ggcccatggt ggagctgatg ttgatcacgc tgccgccgcc
1034221 ggagtgttcc agcatcaacg gcaccgccgc gacggtcagc gcgtgggcgg tgcccacgtt
1034281 gaaggcgaag gcgtccgcga ggtccttggt cgaggtgctt agcagcgtgt tgggcatggt
1034341 gccgccaacg ttgttgacga cgatgtcgag cttcccgaaa gctccgacgg cctgaccagc
1034401 cagctgcgcg gtcacctcgg gatgggccag atcggcggca acggtgtggg cgcggcggcc
1034461 ggcagcgcgg atctgttcgg cgacagcgtc aagctcggat gatgttcgtg aagcgatgag
1034521 gacatccgcg ccggcctggg cgaaagccaa tgcgatggct gctcccaggc cgcggccgcc
1034581 gccggtgatg acggcaacct tgtcgtcaag acggaacata tccaggatca tggcgccctc
1034641 ttttccggct gtcggccgaa acggtaacaa gcttgctgca gcttcctgtg actgctcccg
1034701 aaacctgggg gtgtgcctgc tgtgtatgca cggcatacgg acatccttcc cctgagaccc
1034761 gcggtcgaac cagccacgtg tccatcatca ggggtcaacc ccggccaagg gcgacggcac
1034821 gccaagttcg ccgaccgtta acctagtgct gttagcttca tttgctgcga gcaaaacagc
1034881 tggtcggccg ttaggaactg aattgaaact caaccgattt ggtgccgccg taggtgtcct
1034941 ggctgcgggt gcgctggtgt tgtccgcgtg tggtaacgac gacaatgtga ccgggggagg
1035001 tgcaaccact ggccaggcgt cggcgaaggt cgattgcggg gggaagaaga cactcaaagc
1035061 cagtgggtcg acggcgcagg ccaacgcgat gacccgcttt gtcaacgtgt tcgagcaggc
1035121 ctgccccggc caaaccctga actacacggc caatggttcg ggcgctggaa tcagcgaatt
1035181 taatggcaac caaaccgatt tcggtggctc agatgtaccc ctgagcaagg acgaggccgc
1035241 agcggcgcag cggcgttgcg gctcgccggc gtggaatctg ccggtggtgt tcggcccgat
1035301 cgcggttacc tacaacctca acagcgtttc ctcgctaaat ttggacggcc ccacgttggc
1035361 gaagatcttc aacggctcca ttacgcagtg gaacaatccc gcgatccagg cgctgaaccg
1035421 cgacttcacg ctgccaggtg agcggattca cgtggtgttc cgcagcgatg agtcggggac
1035481 cacggacaac ttccagaggt acctgcaggc cgcgtccaac ggtgcgtggg gtaagggcgc
1035541 tggaaagtcg ttccaaggcg gcgtcggtga gggcgcgcgg ggtaacgatg gcacgtcagc
1035601 ggccgcgaag aacaccccgg ggtcgatcac ctacaacgag tggtcgttcg cccaggcgca
1035661 gcacctgacc atggccaaca tcgtcacttc ggctggtggg gacccggtgg cgattactat
1035721 cgactcggtc ggccagacga tcgccggggc caccatctcc ggggtgggca acgacctggt
1035781 gctcgacacg gactcgttct accggccgaa gcgtcccggc tcctatccga tcgtgttagc
1035841 gacatacgaa atcgtttgct cgaagtatcc cgactcgcag gttggcacgg ctgtgaaggc
1035901 gttcctgcag agcactatcg gcgccggtca aagcggcctg ggggacaacg gatacatccc
1035961 aattccggac gagttcaaat cgaggctgtc gactgcggtc aacgcgatcg cctgatctga
1036021 ggttgacgtg gtcaccgagc cgctcacaaa gccggcgcta gtggcggtcg acatgcgccc
1036081 cgcgcggcgc ggcgagcggc tgttcaagct ggccgcgtcg gccgccggtt cgacgatcgt
1036141 catcgcaatc ctgctgatcg cgatattcct gttggtccgc gccgtgccgt cgttgcgggc
1036201 gaatcacgcc aatttcttca ccagtaccca attcgacacg tcggacgatg agcagctggc
1036261 gtttggtgtc cgggacttgt tcatggtcac ggcgttgagt tcgataacgg ctctggtgtt
1036321 ggcggtgccg gtggctgtcg ggatcgcggt gttcctcacc cactacgcgc cgaggagact
1036381 gtcgcgtcca ttcggcgcga tggtggatct actggccgca gtgccgtcga tcatcttcgg
1036441 gttgtggggg atctttgtgc tggcgcccaa gctcgagccg atcgcgaggt ttctcaatcg
1036501 caacttgggc tggttgttcc tgtttaagca gggcaacgtg tcgttggccg gcggcggcac
1036561 gattttcacc gcgggcatcg tgctgtcggt gatgatcctg cctatcgtca catcgatatc
1036621 acgcgaagtg ttccggcaga ctccgctgat ccaaatcgaa gcagcgctgg cgctaggcgc
1036681 gacgaaatgg gaggtagtgc ggatgaccgt gctgccatac gggcgaagcg gggtggtcgc
1036741 ggcctccatg ctgggtttgg ggcgggctct gggcgaaacc gtggccgtgc tggtcatcct
1036801 gcgctcggcc gcgcggccgg ggacctggtc gctgttcgac ggcggttata cgttcgcttc
1036861 caagatcgcc tccgctgctt cagaattcag cgaaccgctg ccgaccggag cctatatttc
1036921 ggcgggattt gcgttattcg tgctgacgtt cctggtcaat gcggccgctc gcgcaatcgc
1036981 cggcgggaag gtcaacgggt gagtccctca atgagcatcg aggcgctcga ccagccggta
1037041 aagccggtgg tgtttcgtcc gcttacgctg cgacggcgga tcaaaaacag cgtcgcgaca
1037101 acgtttttct tcacctcgtt cgtggtcgcg ttgataccgt tggtctggct gctttgggtg
1037161 gtgattgccc ggggttggtt tgccgtcacc cgatcgggct ggtggaccca ctcgctgcgc
1037221 ggcgtgctgc cagagcaatt cgccggtggg gtgtatcacg ccctgtacgg cacgctggtg
1037281 caggccgggg tggccgccgt gctggccgtg ccgctgggct tgatgaccgc ggtttaccta
1037341 gtggaatacg ggactggtcg aatgtcgcgg gtgactacct tcaccgtcga cgtgcttgcc
1037401 ggcgtgccct ctatcgtggc ggcgttattc gtcttcagcc tgtggatcgc caccctagga
1037461 tttcagcaga gcgcctttgc cgtggcgttg gcgttggtcc tgctgatgtt gccggtggtg
1037521 gttcgggcag gcgaggagat gctcaggttg gtgcccgatg aactgcgaga agccagctac
1037581 gcgttaggcg ttccgaaatg gaagacgatc gtgcggatcg tcgccccgat cgcgatgccg
1037641 ggcatcgtgt caggcatctt gttgtccatc gcgcgcgtcg tcggtgaaac cgcaccggtt
1037701 ctggtgctgg tcgggtacag ccactccatc aacctcgacg tcttccacgg caacatggcc
1037761 tcgctgccgt tgctgatcta caccgaactc accaatcccg agcacgccgg cttcctgcgc
1037821 gtctggggcg cggcgctgac cctgatcatc gtggtcgcca cgatcaacct ggccgcggcg
1037881 atgatccggt tcgtcgcaac ccgacggcgg cgactcccgt tatgacgtga gtttcaccac
1037941 tcggtcgttg ccgcggtcgg cgacgtagac ggtccggtcg ctgtccactg ccaccgcgag
1038001 gggggtgttg aggccggtga acggtagcac tgtcgaggtg gtcgacccgg ccaggagttt
1038061 gaccacctgg tttgtgttgt gctcggtgac gtagacggtt ccggcttcgt ccaccgcgat
1038121 gccccacggt gcggtgatat ccgtgaatgg cagcacgacc tggttattcg actcggcctc
1038181 tagcttgaca accctgttgt tgtcggtgtc ggtgacatag acgttgccgg agttgtcgac
1038241 ggccaccccg tcggggtcgt tgaggccggt gaacggcagc acggtctggg tcttggatcc
1038301 ggccgccaac ttcaccaccc tgttgttgcc ccggtcggcg acgtataccg caccctgggt
1038361 atccaccgcg agaccttcgg ggtagttgag gccgtcgaac ggtagcacgg tctggttgtt
1038421 ggacccggcc gctaacgtca ccacccggtt gttgaaatcg gtgacgtata cggtgccagc
1038481 gccgtccacc gccaacccct gcggctggta cagcccgttg aacggtaaca ccgtcgtgcc
1038541 ggttgacccg gtggccaact tgaccactcg gccgtacatg ccctcactgg tgacgtacac
1038601 gttgccggcg ctgtccactg ccaccccact cggcgagagg cggaagtcga tgccggtgaa
1038661 cggcaacacg gtctgtccgg atgcctgcgt cggcgaccac gaaggtcgta agaccaggta
1038721 gccggcggcg gcgacgatgg ccaccagtac gatcgcggca gcgccgacga cggcccacac
1038781 cttccgtttg ttgccggccg gcggcacagc gtgtcccagg gaggcctgga gcgcattcgg
1038841 gacggcaggg gagtgtccgg tttggctggg ccagttcccg ccgcggctgt ccgctgccag
1038901 gggtccggcc acggtcgcgg agtccccggg cgaccatcgg gcagcacccg gggtcggtgg
1038961 gccggtgccc gccccggcaa tgccggactc ggactggctc aagcccgtat cggccggagt
1039021 ggccagcaag gttgcgttgt caccgcgccg cagaatcgtc gtggcctggt gttgctcgga
1039081 tgtggtgagt gcgtcatggg cggcgatggc cagatcacca gcgctcataa agcgctccgc
1039141 ggggtttttg gccatgcctt tggcgatcac ctgatccagg gccggcggca cgcgcccggg
1039201 ccgtagctgg ctgggctgcg gggcagggtc cattagatgc gcggcgatca accgctcaac
1039261 gctgtcggcc cgatacggtg gggcaccggt caaacactca cccaacacgc acgccaacgc
1039321 atagatatct gcgcgatagg tgacctcatc gccggtgaac cgctccgggg ccatgtagtt
1039381 gtaggttccc acggcggtcc cggtctgggt cagccccggg tcggaggcgg cacgggcaat
1039441 accgaaatcg accagatagg cgaagtcgct cgcggtgacc agaatgtttt ccggttttac
1039501 gtcgcggtgc gttacgccgt tggcatgcgc ggcatccaaa gcggcggcga tctggcgcac
1039561 gatggccaca gctcgggccg gggtcagcgg accatactgt ttcaataggg cgcgtaaaga
1039621 ggtgccgtcg atcatgcgca tttcgacaaa gaactgtccg ttgatctcgc cgtagtcatg
1039681 gatcggcacg atgtgtggct cggtcagccg tcccgcggtg tcggcctcgc gttgcatccg
1039741 tgctcgaaac accgcattgt cggagtactg cggcgagatc aacttcagcg ccaccacccg
1039801 gtgcttgcgg gtgtcctcgg cctcataaac ctcgcccatc ccgcctcggc ccagcagccg
1039861 caatagctga tacggcccaa attgcgaccc tacctgcgga acggcatcgc tcaccgtcga
1039921 attcccttca ctaggtcaag aaatagcatt caccgcggcc gccaattttg cttggaacga
1039981 tttgggcaac ggaatggagc cgtattggtc caggccttct tggcctggac caatcgcggc
1040041 ttgcataaac gcccttaccg cagtaccggt cgtcgcatcc gggtatttcg agcagacgat
1040101 ctcataggtc gccagcacga tcgggtaaga gccaggctgg gtgggcctgt agaacgacga
1040161 cgtgtccaat accaggtcgt tgccttgtcc catgatcttg gccccggcga ttgtcttgcc
1040221 gaccgactcg gtggtgatcg ccactggatc cggacccgcc gacgtgatga tctgggccat
1040281 gttcaactgc ttacccaccg caaacgacca ctcgttgtag gtgatcgacc cgtcggtcgt
1040341 ctgcagtagg gccgacgtgc cgttgttccc gctggcgccg acgccgacgc ccccgttgaa
1040401 cgtttcgctg gcgcctttgc cccacgcccc gttggatgcg ccgtcgaggt atttctggaa
1040461 gttgtccgac gtaccggact tgtcgctgcg gaagataacg ctaatcggtg ttggcggcag
1040521 gtcggtgccg gagttgaggg cttggatctg tggatcattc cacacggtga tggtgccgtt
1040581 gaaaatcttg gcggtagtgg gtccgtcaag attcagcgtg ctcacgccct tgatattgta
1040641 ggtgatcgcg atcgggccga acaccgtcgg caggtcccat gccggggaac cgcaccgctc
1040701 cgccgaccgg tcaggttgac cggtcgacgg attcaacggg acatccgagc cggcgaaatc
1040761 ggtttcgttg ttgagaaact gggtcacccc ggcaccggac ccgttggcgt tgtagtccaa
1040821 cgtgtagccc gggcacgatc gcacgtaggc atagacgaac tgctccatgg cattttcttg
1040881 tgcggtcgag ccgctggagt ggagctcctt cttgccgccg cagtgcaccg acccagacgt
1040941 gccgcctgcg cctgacgacg agctgttggt gccaccgccg catgctgtca acaccagtgt
1041001 gccggcggcc aacaggctta ccgctgcgcc ggatcgggcg aacttcacgc aactcctctc
1041061 gagggggtcg tggtggcgga tccactcgcc accggtggtc gccgagccac cgacccgggg
1041121 tcggtattcg agccgtcacc gttgtgcatc gaaagaggtc tgatcattga aatcctagcg
1041181 ttcaggaggg gccgctgata ctgagggtcg acggcgcgct ttgtccaagg agcatcccaa
1041241 ggagcatgta gtaccctgcg ccgatggcgt gtgaacggct cggcggccag agcggtgctg
1041301 ctgatgtcga cgccgctgcg ccggcgatgg cggcggtgaa cctcaccctg ggtttcgctg
1041361 gcaaaaccgt gctcgaccag gtgagtatgg gctttcccgc tcgtgcggtg acgtcgttga
1041421 tgggaccgac cggttcaggt aagacgactt ttttgcgcac cctaaaccgg atgaatgaca
1041481 aggtctccgg ttaccgctac agcggtgatg tgctgttggg cggacgcagc atcttcaact
1041541 accgcgacgt gctggagttt cgccgccggg ttggcatgct gttccagcgc ccgaatccgt
1041601 tcccgatgtc aatcatggac aacgtgctcg ccggcgtgcg tgcccacaaa ctggtgccgc
1041661 gcaaggaatt ccgtggcgtc gcgcaggctc ggcttaccga ggtcggcctc tgggacgcgg
1041721 tcaaggatcg gctcagcgat tcaccgtttc gactctctgg tggtcagcag cagttgttgt
1041781 gcctagcccg tacgcttgcg gtgaatccgg aggtgttgct gctcgacgag cccacctccg
1041841 cgctggaccc gactaccacc gagaagatcg aagagttcat ccgatcgctc gctgatcgcc
1041901 tcacggtgat catcgtgacc cataaccttg cccaggccgc ccgcatcagc gaccgggcgg
1041961 ccctgttctt cgacggcagg ctggtggagg aagggcccac cgaacagctg ttctcctcgc
1042021 cgaagcatgc ggaaaccgcc cgatacgtcg ccggactgtc gggggacgtc aaggacgcca
1042081 agcgcggaaa ttgaagagca cagaaaggta tggcgtgaaa attcgtttgc atacgctgtt
1042141 ggccgtgttg accgctgcgc cgctgctgct agcagcggcg ggctgtggct cgaaaccacc
1042201 gagcggttcg cctgaaacgg gcgccggcgc cggtactgtc gcgactaccc ccgcgtcgtc
1042261 gccggtgacg ttggcggaga ccggtagcac gctgctctac ccgctgttca acctgtgggg
1042321 tccggccttt cacgagaggt atccgaacgt cacgatcacc gctcagggca ccggttctgg
1042381 tgccgggatc gcgcaggccg ccgccgggac ggtcaacatt ggggcctccg acgcctatct
1042441 gtcggaaggt gatatggccg cgcacaaggg gctgatgaac atcgcgctag ccatctccgc
1042501 tcagcaggtc aactacaacc tgcccggagt gagcgagcac ctcaagctga acggaaaagt
1042561 cctggcggcc atgtaccagg gcaccatcaa aacctgggac gacccgcaga tcgctgcgct
1042621 caaccccggc gtgaacctgc ccggcaccgc ggtagttccg ctgcaccgct ccgacgggtc
1042681 cggtgacacc ttcttgttca cccagtacct gtccaagcaa gatcccgagg gctggggcaa
1042741 gtcgcccggc ttcggcacca ccgtcgactt cccggcggtg ccgggtgcgc tgggtgagaa
1042801 cggcaacggc ggcatggtga ccggttgcgc cgagacaccg ggctgcgtgg cctatatcgg
1042861 catcagcttc ctcgaccagg ccagtcaacg gggactcggc gaggcccaac taggcaatag
1042921 ctctggcaat ttcttgttgc ccgacgcgca aagcattcag gccgcggcgg ctggcttcgc
1042981 atcgaaaacc ccggcgaacc aggcgatttc gatgatcgac gggcccgccc cggacggcta
1043041 cccgatcatc aactacgagt acgccatcgt caacaaccgg caaaaggacg ccgccaccgc
1043101 gcagaccttg caggcatttc tgcactgggc gatcaccgac ggcaacaagg cctcgttcct
1043161 cgaccaggtt catttccagc cgctgccgcc cgcggtggtg aagttgtctg acgcgttgat
1043221 cgcgacgatt tccagctagc ctcgttgacc accacgcgac agcaacctcc gtcgggccat
1043281 cgggctgctt tgcggagcat gctggcccgt gccggtgaag tcggccgcgc tggcccggcc
1043341 atccggtggt tgggtgggat aggtgcggtg atcccgctgc ttgcgctggt cttggtgctg
1043401 gtggtgctgg tcatcgaggc gatgggtgcg atcaggctca acgggttgca tttcttcacc
1043461 gccaccgaat ggaatccagg caacacctac ggcgaaaccg ttgtcaccga cggcgtcgcc
1043521 catccggtcg gcgcctacta cggggcgttg ccgctgatcg tcgggacgct ggcgacctcg
1043581 gcaatcgccc tgatcatcgc ggtgccggtc tctgtaggag cggcgctggt gatcgtggaa
1043641 cggctgccga aacggttggc cgaggctgtg ggaatagtcc tggaattgct cgccggaatc
1043701 cccagcgtgg tcgtcggttt gtggggggca atgacgttcg ggccgttcat cgctcatcac
1043761 atcgctccgg tgatcgctca caacgctccc gatgtgccgg tgctgaacta cttgcgcggc
1043821 gacccgggca acggggaggg catgttggtg tccggtctgg tgttggcggt gatggtcgtt
1043881 cccattatcg ccaccaccac tcatgacctg ttccggcagg tgccggtgtt gccccgggag
1043941 ggcgcgatcg cgctggggat gtcgaattgg gagtgtgtcc gcagggtcac cctgccgtgg
1044001 gtgtccagcg gcatcgtcgg tgcggtggtg ctagggcttg gccgtgcgct gggggagacg
1044061 atggcggtag ccatggtgtc cggcgcggtg ctgggggcca tgcccgccaa catctacgcg
1044121 accatgacca ccatcgccgc caccatcgtg tcgcagctgg attcggcgat gaccgattcc
1044181 accaacttcg cggtgaagac gctcgccgag gtgggtttgg tgctgatggt gatcacgttg
1044241 ctgactaatg tggccgcgcg cgggatggtt cgtcgggtgt cacgcaccgc gcttccggtg
1044301 ggacgcggca tctgacatgg gcgaatcggc tgagtccggg tcccggcagc taccggcgat
1044361 gtccccgccg cggcgatcgg tagcctatcg gcgcaagatc gtcgatgccc tgtggtgggc
1044421 ggcgtgcgtg tgttgtctgg cggtggtgat caccccgacg ttgtggatgt tgatcggagt
1044481 cgtcagccgc gctgtaccgg ttttccactg gagtgtgctg gtgcaggact cccagggcaa
1044541 tggcggcggc ttgcgcaacg ccatcatcgg taccgcagtg ttggccatcg gggtgatcct
1044601 ggtgggtggc acggtgagtg tgttgaccgg gatttatctg tccgaattcg ccaccggcaa
1044661 aacacggtcc attctgcgcg gcgcctacga ggtgttgtcc ggtattccgt cgatcgtgct
1044721 cggctacgtc ggctatttgg ccctggtggt gtacttcgat tgggggtttt cgctggcggc
1044781 cggggtgttg gtgctgtcgg tgatgagcat tccctacatc gccaaggcca ccgagtccgc
1044841 gctggcccag gtgccgacgt cgtatcggga agcggctgag gcactcgggt taccagccgg
1044901 ctgggcgctg cgcaagatcg tgctgaagac ggcgatgccc ggaatcgtca ccgggatgtt
1044961 ggtcgcgctg gccctggcga tcggcgagac ggcgccgctg ctgtacacgg cggggtggtc
1045021 gaattcgccg ccgaccggac aactcaccga ctcgccggtc ggctacctga cctacccaat
1045081 ttggacgttc tacaaccagc catccaagtc ggctcaggat ctgtcctatg acgcggctct
1045141 cttgctgatc gtgttcctgc tgctattgat cttcattggc cggttgatca actggctgtc
1045201 acggaggcgt tgggacgttt gagttggcct tcgagcgcgc cttcacgctg gcctccagct
1045261 tggcgagcag gtcggagacg tcttcgggct cgtccagcaa cctcggttgg tcctcggcgg
1045321 taaatgcctg cccaccttcg agtttggtgt cgatcagctc ctgtaactgc tcctggtagg
1045381 tgtcgtggta gcggtccgga ttgaagtcgt cggccatcga gtccaccacc tggccggcca
1045441 tcttgagttc cgcgggtttg atctccacct tctggtccag caccgggaag tcggggtcgc
1045501 ggatctcatc gggccacagc aacgtgtgca ccatcatcac ctctcgcttg ccgaaatcct
1045561 tgacgcgcaa cgccgccagc ctggtcttgt tgcgcagcgt gaaatgcacg atcgccatcc
1045621 ggtcggtctc ggcgagtgtc ttagccagca gcacatacga tttcgacgac ttcgaatcag
1045681 gctccaaaaa gtagctgcgg tcgaacatca tcgggtccac gtcggcggcg gggacgaact
1045741 ccaacacctc gatctcccgg ctgcgttctt caggcaagct ggcgatgtcg tcgtcggtga
1045801 tcgccaccat ttggccgtcg ccggactcgt aggcccgggc aagatcgcgg tagtcgacca
1045861 cctcgccaca cgcctcgcag acgcgcttgt accggatgcg tccgttgtcc ttggcgtgca
1045921 cctggtggaa cctgatgtcg tggtctgcgg tagcgctgta caccttgacc ggcacgttca
1045981 ccagcccgaa ggcgatcgaa cccgtccaaa tggctcgcat gtaagtgagt atgccttgat
1046041 tgtccgcgag cggaacgtca cggcgaaatt ccacgcgata tttgaccgtg acgttacgct
1046101 cgcgacttgt gtgaccgaca ggctacgttg aaagcatggg ttcggcgtcg gagcaacggg
1046161 tgacgctgac caacgccgac aaggtgctct atcccgccac cgggaccaca aagtccgata
1046221 tcttcgacta ctacgccggt gttgccgaag tcatgctcgg ccacatcgcg ggacggccgg
1046281 cgacgcgcaa gcgctggcct aacggcgtcg accaacccgc gttcttcgaa aagcagttgg
1046341 cgttgtcggc gccgccttgg ctgtcacgtg caacggtggc gcaccggtcc gggacgacga
1046401 cctatccgat catcgatagc gcaaccgggc tggcctggat cgcccaacag gcggcgctgg
1046461 aggtgcacgt gccgcagtgg cggtttgtcg ccgagcccgg atcaggtgag ttaaatccgg
1046521 gcccggcaac gcgtttggtg ttcgacctgg acccgggcga aggcgtgatg atggcccagc
1046581 tggccgaggt ggcgcgcgcg gttcgtgatc ttctcgccga tatcgggttg gtcaccttcc
1046641 cggtcaccag cggcagcaag ggattgcatc tgtacacacc gctggatgag ccggtgagca
1046701 gcaggggagc cacggtgttg gccaagcgcg tcgcgcagcg attggagcag gcgatgcccg
1046761 cgttggtcac ctcgaccatg accaaaagcc tgcgggccgg gaaggtgttt gtggactgga
1046821 gccagaacag cggctcgaag accaccatcg cgccgtactc actacgtggc cggacgcatc
1046881 cgaccgtcgc ggcgccacgc acctgggcgg agctcgacga ccccgcactg cgtcagctct
1046941 cctacgacga ggtgctgacc cggattgccc gcgacggcga tctgctcgag cggctggatg
1047001 ccgacgctcc ggtagcggac cggttgaccc gataccgccg catgcgcgac gcatcgaaaa
1047061 ctcccgagcc gattcccacg gcgaaacccg ttaccggaga cggcaatacg ttcgtcatcc
1047121 aggagcatca cgcgcgtcgg ccgcactacg atttccggct ggaatgcgac ggcgtgctgg
1047181 tctcgtgggc ggtaccgaaa aacctgcccg acaacacatc ggttaaccat ctagcgatac
1047241 acaccgagga ccacccgctg gaatacgcca cgttcgaggg cgcgattccc agcggggagt
1047301 acggcgccgg caaggtgatc atctgggact ccggcactta cgacaccgag aagttccacg
1047361 atgacccgca cacgggggag gtcatcgtga atctgcacgg cggccggatc tctgggcgtt
1047421 atgcgctgat tcggaccaac ggcgatcggt ggctggcgca ccgcctaaag aatcagaaag
1047481 accagaaggt gttcgagttc gacaatctgg ccccaatgct tgccacgcac ggcacggtgg
1047541 ccggtctaaa ggccagccag tgggcgttcg aaggcaagtg ggacggctac cggttgctgg
1047601 ttgaggctga ccacggcgcc gtgcggctgc ggtcccgcag cgggcgcgat gtcaccgccg
1047661 agtatccgca attgcgggca ttggcggagg atctcgccga tcaccacgtg gtgctggacg
1047721 gcgaggccgt cgtacttgac tcctctggtg tgcccagctt cagccagatg cagaatcggg
1047781 gccgcgacac ccgtgtcgag ttctgggcgt tcgacctgct ctacctcgac ggccgcgcgc
1047841 tgctaggcac ccgctaccaa gaccggcgta agctgctcga aaccctagct aacgcaacca
1047901 gtctcaccgt tcccgagctg ctgcccggtg acggcgccca agcgtttgcg tgctcgcgca
1047961 agcacggctg ggagggcgtg atcgccaaga ggcgtgactc gcgctatcag ccgggccggc
1048021 gctgcgcgtc gtgggtcaag gacaagcact ggaacaccca ggaagtcgtc attggtggct
1048081 ggcgcgccgg ggaaggcggg cgcagcagtg gcgtcgggtc gctgctcatg ggcatccccg
1048141 gtccaggtgg gctgcagttc gccgggcggg tcggtaccgg cctcagcgaa cgcgaactgg
1048201 ccaacctcaa ggagatgctg gcgccgctgc ataccgacga gtcccccttc gacgtaccac
1048261 tgcccgcgcg tgacgccaag ggcatcacat atgtcaagcc ggcgctggtt gcagaggtgc
1048321 gctacagcga gtggactccg gagggccggc tgcgtcaatc aagctggcgt gggctgcggc
1048381 cggacaagaa acccagtgag gtggtgcgcg aatgaagtgg gtgacgtatc gaagtgacca
1048441 cggcgaacga acgggagtgc tttccggtga cgccatctac gcgatgccgc cggacgtgtc
1048501 gttgctggat ctggtcgggc gcggcgccga cggtctgcgc acggcgggcg aacgggcagt
1048561 gcgctcaccg gccgcggtgg tagcgctcga cgaggttacg ctggcggcgc cgattccgcg
1048621 cccgccgtcg atccgggact cgttgtgctt tctggaccac atgcgtaact gccaggaagc
1048681 gatggggggc ggccgggtgc tcatggatac ttggtaccgc atcccggcgt tctacttcgc
1048741 gtgcccgtca acggttttgg gaccgtacga cgacgcaccc accgcacccg gaagtgcgtg
1048801 gcaggacttc gaattggaga tcgcggcggt tatcggaacc agcggcaaag acttgaccgt
1048861 cgagcaggcc gaacggtcga tcatcggcta taccattttc aacgactggt ccgcacggga
1048921 cctgcagatg ctggagggcc agctgcgcat cggacaggcc aagggcaaag acagcggtat
1048981 caccctgggc ccctatctgg tcacaccgga tgagctggag ccctattgcc ggggcgggaa
1049041 gctaagcttg cgggtgatcg ccttggtcaa cggcaccgtg atcggatcgg ggtcgaccgc
1049101 acagatggac tggagcttcg gcgaagtcat cgcctatgcc tcgcgggggg tgacgctgac
1049161 cccgggtgac gtgttcggct cgggcacggt gcccacctgc acgctcgtcg agcacctcag
1049221 gccaccggaa tcattcccgg gctggctgca cgacggcgac gtggtcaccc tccaggtcga
1049281 agggctgggc gagacgaggc agaccgtccg gacgagcggc actccttttc cgttggctct
1049341 tcggccgaat ccggacgccg aacccgaccg gcgcggggtc aacccggcac cgacgcgggt
1049401 gccgtttacc cgcgggctgc acgaagtcgc cgaccgggta tgggcgtgga cgctgcccga
1049461 cgggggatac ggcttcagca acgccgggct ggtcgccggg gacggcgcgt cgctgctcgt
1049521 ggataccctg ttcgacctgg cactgacacg cgagatgttg gccgcgatga agccggtcac
1049581 cgagcgggcg cccatcaccg acgccctgat cacgcactcc aacggcgacc acacgcacgg
1049641 cactcaactg ttggaccgct cagtgcgcat catcgccgcc aagggcacct ccgaggagat
1049701 cgagcatggc ccggcaccgg agatgctagc ccggatccaa accgccgacc tgggccccgt
1049761 tgcgacgcgg tatctgcgtg atcgcttcgg tcactttgac ttcagcggca tcaagctgcg
1049821 caacgccgac ctgacgttcg accgcgacct ggccatcgag ctcggcggcc ggcgagtcga
1049881 cctgctcaac ctcggtcccg cgcacaccac cgccgactcg gtcgtgcacg tggccgacgc
1049941 cggtgtgctg ttcgccgggg atctgctgtt catcggttgc accccgattg tgtgggcggg
1050001 cccgatcgcc aactgggtgg cggcctgcga cgcgatgatc gcgctggacg cgcccacggt
1050061 ggtgcctggg catggtccgg tcaccggccc ggacgggatc cgtgccgtcc gtggctatct
1050121 ggcgcacatc gccgaacagg ccgaggcggc ctaccgcaag gggctatcgt tgcccgaggc
1050181 cgtcgagacc atcgacctgg gcgagtacgc gagctggctg gactccgaac gggtagtggt
1050241 caacgtctac cagcgttacc gcgaattgga tcccgacacc ccgcgccagg acttgctggc
1050301 gttgctggtg atgcaggccg aatgggcggc gcgccactgt acgtagccac tcgggcgcgt
1050361 ttgtcacggg aatctgcgga ccggcgggcg catggtttgc ctgtccacga gcgacaaagc
1050421 cagcgcgcca aggattcccg atggcagcca tcactttgtc gcgctgaggc gggcacgaag
1050481 aacatcccgt ccagacagcg gccaatgtgg cgggtgtgaa aggcgccgcc gagcatggca
1050541 ccgggtccaa cggctctcac gaagctgatc ggggatcgat ccgttgtgat gcttaaactt
1050601 tcgcgatgac gttctcggcg aacatctcca gattgcggat cttggtctgc agcggctcgg
1050661 tgtcggggcc catggtgtac gggacacgga aaccgacgat gacgtccgtc acccctttgt
1050721 cctcgagccg cttgacgccg tccacggtga aaccgtccag ggagatcacg tggatttcga
1050781 acgggctggt tttccccgct tcctcgcgaa gccgcttgac cctggcgatc agccggtcga
1050841 gttcgtccgg atcgccgccg ccatgcatcc atccatcggc gcgcgccgcc cgtcgcagtg
1050901 ctgcatcggc gtggccaccg accaggatcg ggatcggctg ggtgggcgcc ggggtcatct
1050961 tggtcttggg tatgtcgtag aactcgccgt ggaactcgaa gtaatcgccg gtggtaaggc
1051021 cacgcacgat ctcgatgcat tcgtcaatcc gcttgccgcg cttagcgaac gggacgccca
1051081 tcagctcgta atcctccggc cacgggctag tgccgacacc cagcccgacc cggttgccga
1051141 tcagggcggc tagggaaccg gcctgctttg ccaccagagc cggcgggcgg atgggcagct
1051201 tgaggacgaa gaagttgaac cgcagcctcg tcgtgactgc gcccaatgct gctgtcagga
1051261 caaaggtttc gatgaaaggc ttgccgtcca tgaattcgcg gttgccgtcg ggtgtgtacg
1051321 ggtacttcga gtcggattcg aaggggtagg cgatgctgtc gggaatcgtc atgctgctgt
1051381 atcccgccgc ttcggctgcc ttggccagcg ggatgtagaa cgtgaagtcg gtcattgcct
1051441 ccgcgtagct gaaccgcacg tgattgcctt cctcgaagtg gccgtcccca acgagattag
1051501 aacgtgttct aatttgacgt gcaagcgggg cgcaacggct tggtcagagt tggttctccg
1051561 gcccaataat tgcccagacc gtcttgcccg acgaagtggg actgctgccc caggcgcggg
1051621 acaacgcggc aacgatcgcc aggccggaaa cgtcgatgcc cttcggtggg gacgccagcc
1051681 gaaccgccgg agcgctgctg ccgtcggaaa ccgcgatggt tgccgttggg ccatcgcttt
1051741 cgatccgcat caccgggtcg cttccggtgt gtttcagcac gttctccacg aatacgttga
1051801 cgacgaccaa cgcgactgga ataagcccgg gacgtgacca ttgggtgagc cattcgcgga
1051861 ccaactggcg tgactcgcga aggctgttca ggttggcggg cagttgtgcg tccgaacgct
1051921 tgaaattgcg gcgcgcgagc cgaccgatgg ccttgctcgc cgctttttcg gtcgggtaca
1051981 ccggcatgaa gcgggcgacc ccggtgcggg tgaccgccgc gcggccggcc cgatggccgc
1052041 agaccagcaa gaccggtaca tccgctcgga agtcggcctg ccagcgggcg ctgataaaga
1052101 ccgaccatgc cgattcctcg gcgacttgca gctcggtgac attgacgata acggcggacg
1052161 gctgctcgag cgtcgccctc gtgaggctgt cccggagcag tgcagaactg ctggagtcaa
1052221 gcgcaccgtc ggcggtcaag atgaccaccg aatcctgtgt acgtaccgca atggccagcg
1052281 ctgtcggtga cttggctgcc gtgctcaccg cgaccacttc cttgcgtccc ttgccccggc
1052341 gtcaggtgca catcgcaact tgggtcggag tgccaccata gccatggttc cgaaacggcg
1052401 ggacgccatg aaccggcatt ccggtcccat cctgtcgtcc ggtttcatag ccagctcctc
1052461 gaactcctgt cccgccaata gcttgaggat gccgtccgcc ttggcggcag aaaccctatc
1052521 ttttgatgat cgcgccgtcc ggcgcagcac ccatcaccca gggggtggtt acccacaaaa
1052581 acacgcgatc aacctccagt ccgggctatg cccagcctat gcaaacgcca gcaggtaggg
1052641 cccgggaatc cggccaacaa agatcaacga acgccgcgcc ggcgccggga tgcgttcaag
1052701 tggtggccga ggctgggccg cttcgggcat agggcggtgg gcccactccg gcgaccgagt
1052761 gggtacccca cggtgtttgt tcagtgatgc gtgcgggtgc gctacgtccg ccgatggtta
1052821 acgtcgccgc ccgggcatgg gtgagtgaag tctcgggcaa ggaatcgaat acggtgccct
1052881 gccagtggta gttgccgtcg atcggatcga ggtgaccggt aagccggacg cggacccgaa
1052941 agcgggcacc agcgagcgtt agcgtcgccg caccgtcgta ggtctgatcg tcctcggtcg
1053001 ccgcggatga caagtcgaac gcttcgaggc ccccagtctg ccgatggggc tgagcgggtt
1053061 tgagttgggc gcgctcgttg aatacctgct ggctgctgcg gcgcacctcg atgcggcggc
1053121 tggccgtgcg ctccatgagc ttcatgcatt cgacgacgca gcgtgcctgc gcggcggtat
1053181 cgggcccggt gatgaagaag tagttgggga aaccgtgaac ggcgacgccg aggtagggct
1053241 ccatgccatc gtcccaggct tggcggatgg tcacaccgcc ggcaccgacc agggtctgat
1053301 cgccgacctg atcggcgatc gcgaacccgg tgccgtagat gatggcgtcg acggggtgtt
1053361 ccacgccatc gctggtgcgg atgcccgagg aggtcagcgc gtcgatcgcc gccgtcgccc
1053421 aggcgaccgc tggatgctca gccccggtgc ggcgacgtag ccagcgtttg gcgcgtgtcg
1053481 tccacagtgg tactccggtg acgacgcggc gcggtgcctg ggtgaagacc gtgaccgacg
1053541 ccgccgattc agacaaccgg ctgatgtagt gggcggcggc ggcatcggtg ccgaccaccg
1053601 cgatgcgttt gccggccggg tcgaaatcgc ggtcccatgc cgccgaagtg ggcctgatgg
1053661 gcccgatcgc ccgtcgcgcc tggaaacgca ccaactttct gtgaccgcga cgctcggcct
1053721 cgctgacgcc ggccaccgca ttgtcatcgt cggcaggggt gctggtggcc gggacgccgc
1053781 agccgcgcgc gctcgggccc gatgcgctgg acgtcagcac cgacgacctg gccgggctgt
1053841 tggccggcaa caccggccgg atcaagaccg tcatcaccga ccagaaggta attgccggca
1053901 tcggcaacgc ctatagtgac gaaatcctgc acgtcgcgaa gatctcgccg ttcgccacgg
1053961 ccggcaagtt atccggcgca cagctcacct gcctgcatga ggcgatggcg tcggtgctgt
1054021 cggacgcggt gcgccggtcc gtcggccagg gcgcggccat gctcaaaggg gagaaacgtt
1054081 ctgggcttcg agtacatgcg cgcaccgggt taccctgccc agtgtgcggt gacaccgtgc
1054141 gggaggtgtc cttcgcggac aagtcttttc agtactgtcc aacgtgtcag accggtggca
1054201 aggcgctggc cgaccggcgt atgtcgcggc tgctcaagta gtcgatatgc tcaccggagt
1054261 gactcgccag aagatcctga tcaccggcgc cagttccggc ctgggcgccg ggatggcccg
1054321 atccttcgcc gcccagggcc gcgacctggc gctctgcgcc cgccgcacgg atcggctgac
1054381 cgaactgaaa gccgaactgt cgcaacggta tcccgacatc aagatcgctg tcgcggagct
1054441 ggacgtcaac gaccacgagc gggtgcccaa ggtattcgcc gaactcagcg atgagattgg
1054501 cggcattgac cgtgtgatcg tcaacgccgg aatcggcaag ggtgcccggc tgggctcggg
1054561 caagctgtgg gcgaacaagg caaccatcga aaccaacctg gtcgccgcac tcgtgcagat
1054621 cgaaacggca ctggacatgt tcaaccagcg cggttcgggg catttggtgc tcatctcctc
1054681 agtgctcggc gtcaaagggg tgccgggcgt caaagccgcg tatgcggcaa gcaaagccgg
1054741 tgtgcgctcg ctaggcgaat cgctgcgcgc cgagtacgcc caacgcccca tcagggtcac
1054801 ggtgctggag ccgggttata tcgagtcgga gatgacggcc aaatcggcga gcacaatgtt
1054861 gatggtggac aacgcaactg gcgtcaaggc gctggtggcc gccatcgagc gcgagcccgg
1054921 acgcgccgcg gtcccctggt ggccatgggc gccactggtg cggctgatgt gggtgctgcc
1054981 gccgcggctg accagacgct tcgcctagcg ggcgctcggc cacctagccc gcgcggccac
1055041 gttcggtgcg gtagcggcgc accagcccgt cggtcgagct gtccgactgc ggtggcggtg
1055101 aaccggcgcc ggtgattacc ggaagcagcg ccttggcctg cgtcttgccc agctccaccc
1055161 cccactggtc gaacgagtcg ataccccaca ccacaccctc ggtgaacacc tgatgctcgt
1055221 agagcgcgat caactgcccc agcaccgacg gcgtgagccg actggccaga attgaggtgg
1055281 acggccggtt gccgggcatc accttatgcg ctaccacgtg ggcgggggtg ccgtcggcgg
1055341 cgatctcctc ggcggtcttg ccgaacgcca gcacctgggt ttgggcgaag aagttgctca
1055401 tcagcagatc atgcatgctg ccggtgccct cggcggtcgg caggtcgtcg aggggttgag
1055461 caaagccgat gaaatcggct ggcaccagcc gggtgccctg gtgcagcaac tggtagaagg
1055521 cgtgctggcc gttggttccc ggttcacccc aaaagatttc accggtgtcg gcgctgaccg
1055581 ggctgccgtc ggcgcgcgtg gacttgccgt tggattccat ggtcaactgc tgaaggtagg
1055641 ccggaaaacg cgacaagtca ttggaatacg gcagcacggt gcgtgattgc gcaccgaaga
1055701 aattggagta ccacagtccg atcaggccaa gcagcaccgg cgcgttggat tccagcggag
1055761 cggtcgcgaa atggcggtcg atgatgtgga atccggccaa gaaatcggcg aaggcgtcgc
1055821 ggccgatcac cgtcatcaac gacagcccga tcgccgaatc caccgaataa cgcccgccga
1055881 cccaatccca aaaaccgaac atgttgtcgg tgttgatgcc gaagtcgtcg accaggcgct
1055941 tgttggtgga caccgcgaca aaatgccgcg acaccgcggc gtcgcccagc gcatcggtca
1056001 gccagcgacg cgccgcggtc gcattggtca atgtctccag cgtcgagaac gtcttcgacg
1056061 cgacgatgaa aagcgttgtg gcggggtcta gatcggcgag cgtggcgatc aggtcggcgg
1056121 gatcgacgtt ggacacgaag cgcgcggaaa tgcccgcgtc ggcatagtgg cgcaacgctt
1056181 ggtacaccat caccggaccc aaatccgaac caccgatgcc gatgttgacg acggtgctga
1056241 tccgctttcc agttgctccg gtccactcgc cgctgcgcag gcggtcggtg aaggcgccca
1056301 tcgcgtcgag cacggcatgt acgtcggtga cgacgtcttg gccgtcgacg acgagttcgg
1056361 cgtctcgggg cagccgcagc gcggtgtgca acaccgctcg atcctcagag gtgttgatat
1056421 gcacaccggc gaacatctgg tcgcgacgct cttcgaggtg ggccgtccgg gccagatcga
1056481 tcagcagcgc cagcgtctcg cgggtgacgc ggtgtttgct gtagtcgatg tagagatcgc
1056541 cgacgctgac ggtgagctcc cggccgcgac ccggatcgtc ggcgaagaac tggcgaagat
1056601 gggtgtttcc gatctgatcg tgatgtctgc gcagggcgtc ccatgccggg gtagcggtga
1056661 tgtcggggat tggcgcggag gtcatggttc gaccctaatg ccgtggagtg gcgtcgatca
1056721 gagccgctgt cttcgccgag cctttagtta tcgtgctcgg cggcactcgc cgtttgtcgc
1056781 ggtatctaca ggctcggcga tgcgggcctg cgctctcgcg gcctcggccc ccgccgaggc
1056841 cgctgaccgt cgcccagcac ccgctgcaga tcaggcagca tggcctgcaa tggcgcacgc
1056901 cagtacgccc aggtgtgggt ttcgccatcc gggaagttga accgccgttg cgccgcttgg
1056961 tacttgcttt gcaaagcctg tcgcctattg ccgctcaact ccgccgaggg cgtgccgttg
1057021 cccgaatacg cccagatacg gggtgctgtt ggccaccagc ttcgcggcat tgaccgttgg
1057081 ctcgctgtgg gcccacgccg gatcggtcgg cgggcccccg gatcaatgac gcggatccgg
1057141 caaccacgcc atttccactc gggatgatcc cctcactcgc cgccagccag tcggccagct
1057201 cttgggccat atcccgccgt tgccgaccgc cggccggtgc cagttggaat agaactcgcc
1057261 atgccaccgg tgggcatggc gagcgacaga ccggtctggt caaccgaata ccggcaggtg
1057321 tatatcccgg ccgttgtagt cgtctcgggc gagtatgccg tcggacaagt accacgcatg
1057381 agggccgcca ccttgaaact ccaccttgat taggcgatgc atcgaccgcg acgggaccat
1057441 cagtcgatgg gtagaccccg ccgcgactac gttgacgagg ttgtcgagct ggcgccttgc
1057501 ccgagcagcg cgatcaaagc tgccgcccat atgaccatca accggcgcaa ttgtgaaact
1057561 ccagctgcct ttgctgcatc catttcggcg gaaattcagc gcagcgatgc agaaattccc
1057621 ggcaaacagc ggcggaagtg acccattagt gaccgaggcg gcccctgccc aatcgcaaaa
1057681 gcaggatggc cagatcctta ccgtcgggtc ccagctcgct gtagcgttcg atgaccttca
1057741 tctcccggct gtgtaccagc cgagtgccac cggacgccat ccgggccttg ccgatggcct
1057801 tggaaacctc agcgcgtcgc ttgactaacg cgaggatttc ggcgtctagc cggtcgatct
1057861 cttcgcgcag cgtgtcgatc tcggggacag gttgggactc gagcatttcc aggttcatgg
1057921 ctgctaactc cgcgttctcg tgatgtgggg gttctggtct catccggtac tgggcctcac
1057981 acaagagacg agccccgaat ccggaagcgg accacggggc tctgcgaaag cagctagacc
1058041 acgggcaccg ctggccggta cccgtagaaa aatcggcgct gcgcgttgag cacgaaccga
1058101 gtgtgccatc aacggacgcg cccgcgcaaa aacttggcgg gaaaagtgca cccaaaattg
1058161 ggtggtggcg ccgaaggacc tgccgcgtgg cgatgagcct ggccaggcta tgccgcggtc
1058221 cgccgactcg tcgccgcgcg gcggtaagtt tggaccgaca tgagtgtgca cgcgaccgac
1058281 gccaagcctc ccggtccatc cccagcggac caactgctcg acggcctcaa cccgcaacag
1058341 cgccaggcgg tcgtgcatga gggttcgccg ctgctgatcg tcgcgggcgc gggttcgggt
1058401 aagaccgcgg tgttgacccg ccgcattgcc tatctgatgg cggcccgcgg cgtcggggtg
1058461 ggccagattc tggccatcac cttcaccaac aaagccgccg ccgagatgcg cgaacgggtg
1058521 gtgggcctgg ttggggagaa ggcccggtac atgtgggtgt cgacgtttca ctccacctgc
1058581 gtgcgtatcc tgcgcaacca ggcggcgctg atcgagggcc tcaactccaa cttttcgatc
1058641 tatgacgccg acgattcgcg gcggttgctg cagatggtgg gccgcgacct gggcctagac
1058701 atcaagcggt actcgccgcg actgctggct aacgccatct ccaacctgaa gaacgagttg
1058761 atcgacccgc atcaggcgct ggccggctta acggaggact ccgatgacct agcgcgcgcc
1058821 gtggcgtcgg tttatgacga ataccagcgg cggctgcggg cggccaacgc gctggacttc
1058881 gacgacctga tcggcgagac cgtcgcggtg ctgcaggcct tcccgcagat cgcccagtac
1058941 taccgtcgga ggttccggca tgtcctggtt gacgaatacc aggacaccaa ccacgcccag
1059001 tacgtattgg tgcgcgagct ggtcggccgc gacagcaatg acggtattcc ccccggcgag
1059061 ttgtgcgtcg tcggggatgc cgatcagtcg atctatgcgt tccgcggcgc caccatccgc
1059121 aacatcgaag acttcgaacg tgactacccc gacaccagaa ccattctgct ggaacagaat
1059181 taccgctcga cgcagaacat cctgtcggcg gccaactcgg tgattgcccg taacgcgggg
1059241 cgccgggaga agcggttgtg gaccgacgcc ggcgccgggg agttgatcgt tggctatgtc
1059301 gccgacaacg agcacgacga ggcccggttc gtggccgagg agatcgatgc gctcgccgag
1059361 ggtagcgaga tcacctacaa cgatgtcgcc gtcttctacc gcaccaacaa ctcgtcgcgg
1059421 tcactggaag aggtgctgat ccgcgccggt attccgtaca aggtcgttgg gggagtgcgc
1059481 ttttacgagc gcaaggagat tcgcgacatc gttgcctacc tgcgcgtgct ggacaacccg
1059541 ggcgacgcgg tcagcctacg gcgcatcctt aacaccccgc gccgcggtat cggggatcgt
1059601 gccgaggcgt gtgtggcggt gtacgccgag aacaccggcg tcggcttcgg tgacgcgctc
1059661 gtcgccgcgg cccaaggcaa agtaccgatg ctgaataccc gggcggagaa ggcgatcgcg
1059721 ggtttcgtcg agatgttcga cgagctgcgg ggccgcctcg atgacgacct gggggagctg
1059781 gtcgaggcgg tgctggaacg caccggatac cgccgcgagc tggaagcgtc caccgatcca
1059841 caggaattgg cccgcctgga caacctcaac gaattagtca gcgtcgcaca cgaattcagt
1059901 accgaccggg agaatgccgc cgcacttggc ccagacgacg aagacgtccc cgacaccggt
1059961 gtgctggcgg attttctgga acgggtgtcg ctggtcgccg acgccgatga gatcccggag
1060021 catggcgcgg gtgtggttac cttgatgacc ttgcacaccg ccaagggttt ggagttcccg
1060081 gtggtgtttg tgaccggctg ggaggacggg atgttcccgc acatgcgggc gttggacaac
1060141 ccgaccgagt tgtccgagga gcggcggctg gcctatgtcg gcatcacccg cgcccggcag
1060201 cggttgtacg tgagccgggc gatcgtgcgt tcgtcttggg gccagccgat gctcaacccg
1060261 gagtcgcggt ttctgcggga aatcccgcag gagctcatcg actggcggcg caccgccccg
1060321 aagccgtcgt tcagtgcccc ggtgagtggc gccggtcggt tcggtagcgc gcgtccatca
1060381 ccgacccgct cgggggcgag caggcgcccg ctgctggtgc ttcaggtcgg cgaccgcgtg
1060441 acccatgaca aatacggcct gggccgtgtc gaggaggtct ccggtgtcgg cgaatcggcg
1060501 atgtcgctga tcgacttcgg tagctcgggg cgggtgaagc tgatgcacaa ccacgcccct
1060561 gtcaccaagc tctgagattt cgcgccgagc gtgaagtcac ggcggctatt tcgcggattt
1060621 ctcgccctga gaacacgttc ggcgtcgttg ccgggtcaac cggtgtaatt gccgacgcta
1060681 agtccccgct tggcgagcca cggcactggg tccacgcgct cggtgccgcc caggagcacc
1060741 tcgaagtgca ggtgcgggcc ggtggaaaag ccacggctgc ccatggtggc gatctggtcg
1060801 cctgccatca cgcgctcacc gacgctgacc aacgtggtat tgacgtggcc gtatagcgtg
1060861 accgtgccgt cggcgtgcag cagcttgacc cacattccgt agccggcggt ggggccggcg
1060921 tcgatgacga cgccgtcgga caccgcataa atcggggttc cgatcgcgtt agccaggtcg
1060981 ataccggcgt gcagtacacc ccatcgataa ccgaaactcg acgtgaagat gcccttcgtc
1061041 ggcatgacat acagcgggcg ctgtagtcgc gcctcgcgct cggcgcgctc ctcggcgaag
1061101 gcaacccccc tggcgaactc cgcgttgtgc accgcagcac tcgccgccgg ctgggcggcg
1061161 atgacctgga cgccccgcgg tgggttgctt cccgaccctt cgttgagcgc cgatgcatga
1061221 gcggtcagca cggtctcggt gcgtggggtt tccgactgtt ggatcgccgt atgcgctgct
1061281 gcggccgccg cgcccgcggc catcgccgag atcagcaggc gcccccgggc cgcaccgatc
1061341 ggttgcttgc ggtgctgccc gacgcgccgg gacaccgggg tgacctccgg ggtcagcacg
1061401 accgtggggg ctaccagcca ttcgggggcc agatcgtcgg cgtcgtccag gtcgtcgagt
1061461 tctggagccg ctagcaactg cgcttcgtag tcgaagacgc agtcgtcccc taggtccagg
1061521 tcatcgagct ctgcgaaatc cagctcatcg tagagtgcta agccgtcgag gaatccgtcc
1061581 agcgggatga tttcggtgac ttcgttacgg tgatgatgcg gccaacgatc gcgaggtgtg
1061641 cgaatcgctg ccatggcagc agaacgggcg atacggtgct gggacaaatc tgaaatgtcc
1061701 tcggatcgtg accataacgt tatctggacc ctgagacgtt atccgcaacc ggatggtagt
1061761 ggcaacttca gcgcggaatt cggctgtgat tgtgagttgg atcacgtttc ggctggacaa
1061821 acatatcggt gagctgtgcc acaccgggtg gatgcggccg cggagttaat cggcggtctc
1061881 gatacagttc tccgtgcgag tcgccgattt cggcaccgcc tacctattgg tcgagcagta
1061941 agccgagcga agacggtgag cccatggatc ttttcgagta tcaagccaag gagttattcg
1062001 ccaagcacaa cgtgcccagc acgccgggtc gggtgaccga cacagccgag ggtgccaagg
1062061 ctatcgccac ggagatcggg cgtccggtga tggtcaaagc gcaggtcaag atcggcggcc
1062121 ggggcaaggc cggtggcgtc aaatacgccg cgaccccaca agacgcgtac gagcacgcca
1062181 agaacatcct cggcctggac atcaaaggac acatcgtcaa gaaactgctg gtcgctgagg
1062241 ctagcgatat cgccgaggag tactacctat ccttcctgct cgaccgggcc aaccgcacct
1062301 acctggcgat gtgctcggtg gagggcggca tggagatcga agaggtagcg gccaccaaac
1062361 ccgagcggct cgccaaagtc ccggtgaatg ccgtcaaggg cgttgaccta gatttcgcgc
1062421 ggtccatcgc cgaacagggt catcttccgg ccgaggtgct cgacaccgca gcggtcacca
1062481 tcgccaagct gtgggagctc ttcgtcgccg aggacgcgac gctggttgag gtcaacccgt
1062541 tggtgcggac gcctgaccac aagatcctcg cgctggatgc caagatcacc ctcgacggca
1062601 acgccgattt ccgtcagcct ggccatgccg agttcgagga tcgagctgcc accgatccac
1062661 tggagttgaa ggccaaggag cacgacctca actacgtcaa gctggacggt caggtgggga
1062721 tcatcggcaa tggcgcgggc ttggtgatgt cgactctcga cgtcgtcgcg tatgccggtg
1062781 agaagcacgg cggagtcaag ccggccaact tcctggatat cggcggcggc gcttcggccg
1062841 aggtgatggc cgcgggtctg gacgtggtgc tgggcgacca gcaggtcaag agcgtgttcg
1062901 tcaacgtctt cggtggcatc acctcgtgcg atgcggtggc gaccgggatc gtcaaggcgc
1062961 tgggcatgct gggtgacgaa gccaacaagc cgctggtggt tcggctcgac ggcaacaacg
1063021 tcgaggaagg ccgtcgcatc ctgaccgagg ccaaccaccc cctggtgaca ctggtggcga
1063081 cgatggacga agccgccgac aaggccgctg agctggcgag cgcctgagcg aaaggaccca
1063141 tgactcacat gtccatattt ctgagcaggg acaacaaggt cattgtgcag ggcatcaccg
1063201 gcagtgaggc caccgtccat accgcgcgaa tgctgcgggc gggcacgcaa atcgtcggcg
1063261 gtgtgaacgc acgcaaagcg ggcaccaccg tcacgcatga ggataagggc ggccggctga
1063321 tcaagctgcc ggtgttcggc agtgtcgcgg aggcgatgga aaagaccggc gccgatgtgt
1063381 cgatcatctt cgtgccgccg acgttcgcca aggacgccat catcgaggcc atcgacgccg
1063441 aaattccgct gttggttgtg atcaccgagg gaattccggt gcaggacacc gcctatgcct
1063501 gggcctacaa cctcgaggct ggccacaaga cccgcatcat tggccccaac tgtcctggca
1063561 ttatcagtcc cggtcagtcg ctggccggta tcacgccggc caacatcacc ggacccggtc
1063621 caattggtct ggtgtccaag tcggggacgt tgacctacca gatgatgttc gaactgcgcg
1063681 accttggatt ctccacggcg atcggcatcg gtggtgatcc ggtgattggc actacccaca
1063741 tcgacgccat cgaggccttc gagagggatc cggacaccaa gctcatcgtg atgatcggcg
1063801 agatcggtgg tgacgccgag gagcgggccg cagacttcat caagaccaac gtgtccaagc
1063861 cggtcgtcgg ctatgtcgcc ggatttaccg cacccgaagg caagacgatg ggccacgccg
1063921 gcgccatcgt ctccggctcg tctggcacag cggcggccaa gcaagaggcc ctggaggccg
1063981 ccggtgtgaa ggtcggcaag accccatcgg cgaccgcggc gctggcccgg gagatcttgc
1064041 tcagtctcta gggcgagcag acgcataagc ccccgcacgc tcggcgtgtc gggggcttat
1064101 gcgtctgctc gccctatacg caacaggcca acttggcggc cagccgctcc acgtacgcgg
1064161 ctgcgtcgtc tgcagacctg tccggcatac cgaacagcac ctccgtaacg ccaagctcgg
1064221 cccagcgcgc cagcttgtcg ggcaccggtt tgacgtccag ggccacgatc tgtggaagcc
1064281 cgtcgcggcc ggcggccgcc cagatgtctt gcagtaactt caccggctcg tcgatgtcga
1064341 cgtcgcgtgg agtggtgatc cagccgtcgg cgctgcgcgc gatccacttg aagttcttct
1064401 ccgtccccgc agcgcctacc agcaccggga tgtgcggctg caccggcttg ggccaggccc
1064461 agctaggtcc gaacttgacg aactcgccgt catagcaggc ctcctcttgg gtccacaacg
1064521 cccgcatcgc ctcgaggtat tcgcgcagca tggtgcggcg gcgtccgggt ggcacaccat
1064581 gatcgacgag ctcgtcggtg ttccagccga acccgacccc gacgctgacc cggccgtgcg
1064641 acaaatgatc cagcgtcgca atgcttttcg ccagcgtgat cggatcatgc tcgaccggca
1064701 gcgccaccgc ggtggcaagc cggatccgcg acgtcaccgc cgatgctgct cccaggctca
1064761 cccacgggtc caacgtgcgc atatagcggt cgtccggcag cgaagcgtca cccgtcgtcg
1064821 gatgggccgc ctggcgcttg accgggatgt gggtgtgttc gggcacgtaa aacgtgcgaa
1064881 acccgtggct ttcagcaagt ctggcggccg cggccggggt gatgccgcgg tcgctggtga
1064941 acagcacaag tccgtagtgc atgcaccgaa ttagaacgtg ttccacctgc gccgggcaag
1065001 cggccgtcca gtcgttaatg tcgcgagcgc cggtcgctcc ggcagcggca cccgaacgtg
1065061 cgctagcgtg gttgatcgaa tcgcgtcgcc gggagcacag cgtcgcactg caccagtgga
1065121 ggagccatga cctactcgcc gggtaacccc ggatacccgc aagcgcagcc cgcaggctcc
1065181 tacggaggcg tcacaccctc gttcgcccac gccgatgagg gtgcgagcaa gctaccgatg
1065241 tacctgaaca tcgcggtggc agtgctcggc ctggctgcgt acttcgccag cttcggccca
1065301 atgttcaccc tcagtaccga actcggcgga ggtgatggcg cagtgtccgg tgacactggg
1065361 ctgccggtcg gggtggctct gctggctgcg ctgcttgccg gggtggctct ggtgcctaag
1065421 gccaagagcc atgtgacggt agttgcggtg ctcggggtac tcggcgtatt tctgatggtc
1065481 tcggcgacgt ttaacaagcc cagcgcctat tcgaccggtt gggcattgtg ggttgtgttg
1065541 gctttcatcg tgttccaggc ggttgcggca gtcctggcgc tcttggtgga gaccggcgct
1065601 atcaccgcgc cggcgccgcg gcccaagttc gacccgtatg gacagtacgg gcggtacggg
1065661 cagtacgggc agtacggggt gcagccgggt gggtactacg gtcagcaggg tgctcagcag
1065721 gccgcgggac tgcagtcgcc cggcccgcag cagtctccgc agcctcccgg atatgggtcg
1065781 cagtacggcg gctattcgtc cagtccgagc caatcgggca gtggatacac tgctcagccc
1065841 ccggcccagc cgccggcgca gtccgggtcg caacaatcgc accagggccc atccacgcca
1065901 cctaccggct ttccgagctt cagcccgccg ccaccggtca gtgccgggac ggggtcgcag
1065961 gctggttcgg ctccagtcaa ctattcaaac cccagcgggg gcgagcagtc gtcgtccccc
1066021 gggggggcgc cggtctaacc gggcgttccc gcgtccggtc gcgcgtgtgc gcgaagagtg
1066081 aacagggtgt cagcaagcgc ggacgatcgg gcggccggcg ctcgtccagc tcgcgacctc
1066141 gtcagggttg cgttcggccc aggtgtggtg gcgttgggca tcatcgccgc ggtgacgctg
1066201 ctccaattgc tgatcgccaa tagcgacatg accggtgcgt ggggcgccat cgccagcatg
1066261 tggctgggcg tgcacctggt gccgatctcg atcggtggcc gcgcactggg cgtcatgccg
1066321 ctgttgccgg tcctgttgat ggtgtgggcc accgcgcgca gcacggcgcg ggccacatcc
1066381 ccacagtcgt cagggctcgt tgttcgctgg gtcgtcgcgt cggccctggg cggaccgctg
1066441 ctgatggcgg cgattgccct ggcggtcatt cacgacgcgt catcagtggt caccgagctg
1066501 cagacgccca gcgccctgcg cgcgttcact agtgtgctgg ttgtgcattc cgttggggcc
1066561 gcgaccgggg tgtggtcccg ggtaggtcga cgggcgctag ccgccacggc actgcccgat
1066621 tggctgcatg attcgatgcg tgccgccgcc gctggggtgc tggcgttgct cgggctttcc
1066681 ggcgtggtga cggcggggtc gctggttgtg cattgggcga cgatgcaaga gctctacggg
1066741 atcaccgatt cgatattcgg ccagttcagc ctcactgtac tttcggtgct ttacgcaccc
1066801 aacgtcatcg tcggcacctc ggccatcgcg gttgggtcca gtgctcacat tggcttcgcg
1066861 acgttcagtt cgtttgcagt tttgggcggc gatatcccgg cactgccgat cctggccgcg
1066921 gccccgacgc cgccgctcgg cccggcatgg gttgccttac tcattgtggg tgcttcgtcg
1066981 ggtgtggcgg tcggtcagca gtgcgcccgc cgcgccctgc cgtttgttgc ggctatggcc
1067041 aagctgctgg tcgctgccgt tgccggggca ttggtaatgg cggttctggg ttacggcggt
1067101 ggcggccggc tgggcaattt cggcgatgtc ggcgtggacg agggcgcctt ggtgttgggc
1067161 gtgctcttct ggtttacgtt cgtaggatgg gtcacggtgg tgattgccgg cgggatcagc
1067221 cgccgcccca agcggctccg gccggccccg ccggtcgagc tggacgccga tgaatcttcg
1067281 ccaccggtag acatgttcga cggggcagcg agcgagcagc cgcccgcttc ggtcgcggaa
1067341 gacgtcccgc ctagccacga cgacatcgcc aacggcctca aggcccctac tgccgacgac
1067401 gaggcgctgc ccttgtccga cgaaccgccg ccgcgggccg actaatctgc ggttggtgag
1067461 gccgcaactg tctgaggcct ttactcacgg tactgagtct gcactgggat gcaggctggt
1067521 ggtgctcaca cgctttgagg agccagacta ggctcgccgt gtgcaggaac cgcttcgtgt
1067581 acccccgagt gcacctgcgc ggctggtagt actcgcgtct ggcaccggtt cgttgctgag
1067641 atctctactc gatgccgctg tcggcgacta cccggcacgg gtagtcgccg ttggtgtgga
1067701 tcgcgaatgc cgggccgccg aaatcgccgc ggaagcatcg gtgccggtgt tcaccgttcg
1067761 gctcgccgac caccccagtc gcgatgcctg ggacgtcgcc atcaccgccg ccaccgcagc
1067821 ccatgagccc gacctcgtcg tttctgcggg ctttatgaga atccttggac cgcagttcct
1067881 ttcacgattc tacgggcgca ccctcaacac ccacccggcg ctgctgccgg ccttccccgg
1067941 cacgcacggt gtcgctgacg cgctggccta cggggtgaag gtcaccggcg ctacggtgca
1068001 cctggtagac gctggcacgg acaccgggcc aatactggcg cagcaacctg tgccggtgct
1068061 cgacggtgac gacgaagaga ctttgcatga acgaatcaag gtcaccgaac gacggctgtt
1068121 ggtagcggcg gtggccgcac tggccaccca tggcgtgacg gtggtcggac gaacagcgac
1068181 gatgggacga aaggtaacca taggatgagc accgacgacg gaagacggcc gatccgccgt
1068241 gcgctgatca gcgtgtacga caagaccggg ctggtagacc tggcacaggg cctgagcgcg
1068301 gccggcgtcg agatcatctc gactgggtca acggccaaga ccattgccga caccgggatt
1068361 ccggtgaccc ccgtggagca gctgaccggc tttcccgagg tgctcgatgg ccgggtcaag
1068421 acactgcacc cacgagtgca tgccgggctg ctggctgacc tgcgcaagtc cgagcacgcc
1068481 gcggccctcg agcaactcgg gatcgaggct ttcgaactcg ttgtagtcaa cttgtatccg
1068541 ttcagccaga ccgtcgaatc cggcgccagt gtcgacgact gcgtcgagca gattgatatc
1068601 ggcgggccgg cgatggtgcg ggccgccgcc aaaaaccatc ccagcgcggc ggtggtcacc
1068661 gatccgcttg ggtaccatgg cgtgcttgcc gcactgcgcg ccggcggatt caccctcgcc
1068721 gagcgcaaaa ggctggcgtc gttagcgttt cagcatatag ccgagtacga catcgccgtc
1068781 gcgagctgga tgcaacagac cctagcgccc gaacatcctg ttgccgcctt tccgcagtgg
1068841 ttcggccgaa gctggcgccg cgtggcgatg ctgcgctacg gcgagaaccc gcaccaacag
1068901 gccgctctct acggcgaccc caccgcctgg ccggggctgg cccaggccga gcaactgcac
1068961 ggaaaagaca tgtcctacaa caacttcacc gatgcggacg cagcctggcg ggccgccttc
1069021 gaccacgaac aaacgtgcgt ggcgatcatc aagcacgcca acccgtgcgg catcgcaatc
1069081 tcgtccgttt cggtcgccga cgcgcatcgc aaggctcacg aatgcgatcc gctgagcgcc
1069141 tacggcgggg tcatcgccgc caataccgag gtcagtgtcg aaatggccga gtatgtgagc
1069201 accatcttca ccgaagtcat cgtcgcgcct ggctacgccc ccggggccct cgatgtgctg
1069261 gcccgcaaga agaacatccg ggtgctggta gccgccgagc cactggccgg tggcagcgag
1069321 ttgcgtccga tcagcggtgg actgctgata cagcagagcg accagcttga cgcgcacggt
1069381 gacaacccgg cgaactggac cttggcgacc gggtcacctg cggaccccgc gacgctgacc
1069441 gacctggtct tcgcgtggcg agcctgccgt gcggtcaagt cgaacgcgat agtgatagct
1069501 gccgacggcg ccaccgtcgg cgtcgggatg ggtcaggtca accgtgtcga cgccgcccgg
1069561 ttggccgtcg aacgcggcgg cgagcgggtt cgcggcgcgg tggcagcctc ggatgcgttc
1069621 ttcccctttc ccgacggcct ggaaacgttg gccgccgcgg gggtcaccgc ggtcgtccac
1069681 cccggtggct cggtgcgcga cgaggaagtg accgaagcgg cggccaaggc cggtgtcacc
1069741 ctatatctca ccggggcgcg gcacttcgcg cactgaggcc gctggccgcg acagtgaaat
1069801 ccacgacgtg acacgccgga aacgcgtcgt gacattcact ctcgtggcca gaagaaagac
1069861 ggcgtcgtag cgtggaacgg tgatgtcacc cagtaacctg ccccgcaccg tgggcgagct
1069921 gcgtgccgcc ggtcatcggg aacggggggt caagcaggaa atccgggaaa atctgctgac
1069981 cgcgctggcc gacggcgaca acgtctggcc gggcatcctg ggtttcgacg acaccgtgat
1070041 tccccaggtg gagcgggcct tgatcgccgg tcacgacttt gtcctgctcg gcgaacgcgg
1070101 ccagggcaag acccggctgc tgcgcgcact cgcgggtctg ctggacgagt ggacgccggt
1070161 gatcgccggc gccgaactgg gcgagcaccc ctacacgccg atcacgccgg agtcgatccg
1070221 gcgggccgcg cagctcggcg acgacctacc ggtggcgtgg aagcaccgca gcgagcgcta
1070281 caccgagaag ctggccaccc ccgacaccag cgtcgccgac ctggtcggcg acgtcgaccc
1070341 gatcaaggtt gccgagggcc gcagcctcgg ggatcccgaa accatcgcct acgggctcat
1070401 cccgcgggcg caccgcggca tcgtcgcggt caacgagctg cccgacctcg ccgaacgcat
1070461 ccaggtgtcg atgctcaacg tcatggagga gcgcgacatc caggtccgcg gctacacgct
1070521 gcggctgccg ctggatgtgt tggtggtcgc cagcgccaac cccgaggact acaccaaccg
1070581 tggccgcatc atcacgccca tcaaggaccg gttcggcgcc gagatccgca cccactaccc
1070641 actggagctg gaggcggaga tgggcgtcat cgtccaggag gcgcacctga gtgcacaggt
1070701 gtccgactac ctgatgcagg tgctcgcgcg gtttgcccgt tacctgcgag aatcccgctc
1070761 gatcgatcag cgctccgggg tgtcggcgcg gtttgccatc gcagcggccg aaaccgtggc
1070821 ggctgccgcc cggcaccgcg gggcggtgct gggggagaca gacccggtgg cccgggtggt
1070881 cgatttgggc acggtgatcg acgtgctgcg cggcaagctg gaattcgagt ccggcgagga
1070941 gggccgcgaa caggcggtgc tcgagcatct gttgcgtcgc gccaccgccg ataccgcgtc
1071001 ccgggtgctg ggcggtatcg acgttggctc gttggtgacc gcggtcgagg gcggttcggc
1071061 ggtgacgacg ggcgagcggg tctcggccaa ggatgtgctg gcggcggtgc cgggcctgcc
1071121 ggtggtggac aggatcgcgc gcaagctggg cgccgaatcc gagggggagc gtgccgcggc
1071181 actggaactg gcgttggagg cgctatacct ggccaagcgc gttgacaagg tctgcgggga
1071241 gggccagacc gtctatggct aagtctgatg gtgacgaccc gctgcgcccg gcttcgccgc
1071301 gcttgcgatc gtcacgacgg cactcgctac gctactcggc gtacaccggc gggcccgacc
1071361 cgctggcccc gccggtggat ctgcgggatg cgctggaaca gattggccaa gacgtcatgg
1071421 cgggcgcctc gccgcgccgg gcgctgtccg agctgctgcg gcggggcacc aggaacctga
1071481 ccggcgccga ccggctggcg gccgaggtga accgccgccg acgggagttg ttgcgccgca
1071541 acaacttaga tggcaccttg caggagatca agaagctgct cgacgaggcc gtgctggccg
1071601 aacgcaagga gctggcccgc gcgctagacg acgacgcccg cttcgccgag ctgcagctgg
1071661 acgcgcttcc ggcctcgccg gccaaggcag tacaggagct ggccgaatac cgctggcgca
1071721 gcgggcaggc ccgcgaaaag tatgagcaga tcaaggattt gctcggccgt gagctgctcg
1071781 accaacgctt tgccggcatg aagcaggcgc ttgccggtgc caccgacgac gatcgccggc
1071841 gggtcaccga gatgctcgac gacctcaacg acctgttgga taagcacgcc cgcggtgaag
1071901 atacgcagcg ggacttcgac gagttcatga ccaagcacgg cgagttcttc ccggagaacc
1071961 cgcgcaacgt cgaggagctg ctggactcgc tggccaagcg agccgccgcc gcgcagcggt
1072021 tccgcaacag cctgagccag gaacagcggg acgagctgga cgcgttggcg cagcaggcat
1072081 ttggctctcc ggcgttgatg cgggcgctgg accgtttgga tgcgcatctg caggccgccc
1072141 gtcccggcga agactggacc ggctcgcagc agttctccgg tgataatccg ttcggcatgg
1072201 gggaaggcac ccaggcgctg gccgacattg ccgagctgga gcagctggcc gagcagctgt
1072261 cgcagagcta tccgggcgcc agcatggacg atgtcgacct ggacgcgctg gcccgtcagc
1072321 tcggcgacca ggccgccgtc gacgcccgga cgctggctga attggaacgc gcgctggtca
1072381 atcagggctt cctggaccgc ggttccgacg gccagtggcg gctctcgccg aaggccatgc
1072441 gccgcctcgg cgaaacggcg ttacgcgatg tggcgcaaca actttccggg cgccacggcg
1072501 agcgtgatca ccggcgtgcc ggcgccgcgg gcgagctgac cggtgcgacg cggccctggc
1072561 agttcggcga caccgagccg tggcacgtcg cccgcacgct gaccaatgcc gtgctgcgcc
1072621 aagccgcggc cgtgcatgac cgcatccgga tcaccgtcga ggatgtcgag gtcgccgaga
1072681 ccgaaacgcg cacccaggcc gctgttgcgt tgttggtgga cacctcgttt tcgatggtga
1072741 tggagaatcg ctggttgccg atgaagcgca cggcgctggc gctgcaccac ctggtgtgca
1072801 cccggttccg ctcggatgcc ttgcagatca tcgcgtttgg gcgctacgcc cgcacggtga
1072861 cggcggccga gctgacgggg ttggcgggtg tctacgagca gggcaccaac ctgcaccatg
1072921 cgctcgcgct ggccggccgg cacctgcgcc ggcacgcagg cgcccagccc gtggtgctgg
1072981 tggtgaccga cggcgagccg accgcccacc tggaggactt cgacggcgac ggtacgtcgg
1073041 tgttctttga ttacccgccc catccgcgca ccatcgccca caccgtgcgc gggtttgacg
1073101 acatggcgcg gctgggtgcg caggtgacga tcttccggtt gggcagtgac cccggtctgg
1073161 ctcggttcat tgaccaggtt gcgcgacggg tgcagggccg cgtggtggtg cccgatctcg
1073221 acgggctggg cgcggcggtg gtgggcgact acctgcgctt ccggcggcgc tagtttgttg
1073281 caatcatggt gctagcatcg tgctagcaat atgctaacat agtgcgatga agacgctgta
1073341 tctgcgcaat gtgccggacg acgtggtcga gcgactcgag cgcctcgccg aactcgccaa
1073401 gacgtcggtg tccgcggttg ctgtgcgtga gctcaccgag gcttctcgcc gcgccgacaa
1073461 tccggcgctt cttggggact tgcccgatat cggcatcgac acgaccgaac tgatcggtgg
1073521 tatcgacgcc gagcgcgccg gtcgatgatc gtcgttgacg cctcggccgc gctggccgcg
1073581 ctgctcaacg atggacaagc tcgacaattg atcgctgccg agcgcctgca tgtcccgcat
1073641 ctggtcgatt cggaaatcgc gagcgggctc cgcaggctag cgcagcggga tcggctgggc
1073701 gcggccgacg gacggcgggc cctccaaacg tggcgccgcc tcgcggtgac gcgttatccg
1073761 gtggtgggcc ttttcgagcg tatctgggaa atccgcgcga acctgtcggc atacgacgcc
1073821 agctatgtgg ccttggcgga agccctgaac tgtgcgctcg tcacagcgga tctgcggctc
1073881 agcgacaccg gccaagccca gtgtccgatt accgttgtgc ccaggtagcc gtggcacgga
1073941 tgttcgagga tccgtatatc acaacgcgat aggtcctgtt gacacaaggg aagcgcgggg
1074001 cgccgtcggc ggttcgtctc gtcgaaatgc gacaacaacg ccgtgcgcgg cacatcccag
1074061 tttgtgagac actgtgcgcg tgccctcgca gtggatgatc tcatcccggg taacggtagc
1074121 ctggaacatc gtcggctacc tcgtgtatgc ggccctggct tttgtcggcg ggtttgcggt
1074181 ttggttctcc ttattcttcg cgatggccac cgatggttgt cacgactcag cttgcgacgc
1074241 aagctatcac gtgttcccgg ccatggtcac catgtggatc ggagttggcg cggtcttgct
1074301 gctcaccttg gtggtcatgg ttcgcaactc gtcgcgaggc aacgtcgtga tcggatggcc
1074361 ttttgttggg ttgttggcgc ttggccttgt ctacgtggct gccgatgcgg tcttgcactg
1074421 atcgacgtgg ggttctgcgt cagtaggcgt cgcgggttcg gccgccgggg gatccgtaca
1074481 ggtacgggta gtgcacgtcg gggtcgttgg ccggtcgcat gttcagcggt ggcggcgcgg
1074541 tgcgccaggc ggccggggga tggcaaccgg tgttgtagga gtagccgagt gggccgcggt
1074601 tgtcgccatt gacgaggttt atcgtgacgc cgtcatcgcg gatttgagag taattcgggg
1074661 cgcccagcgg ctgtggcggg tcgccgggta cggagttgtt gggccgaaaa cccgccgcct
1074721 tgaacaccgg ggctagctcg gtgacaattt gcagccattg ctgcggagtg ggcgctggac
1074781 ggccaaagaa taactcgctt gcctcttgtc gaccgatggt gcgggtgaac gggtcgttgc
1074841 agccgttggt gagatggctc actgtgacgc ctgttgagaa ccgggtctgc ggtgaatatt
1074901 tcgcgatcat cgccctgatg gtggcgtcga ggttggcgag ctgctgctgg actgtctcaa
1074961 gatcgggtcg tccgttgacg attttctgcc ggcggtccag ctcgccccgc ccgggattgg
1075021 cgtaagggtc gaacgtattg ggtttgatac acccggccag cagtgcggcg atgccgagga
1075081 gcgccgcggt caggctgcgg gatgttcgct tcatgggtga tagttcgggt tgggtattgg
1075141 caatccgaac gggccgggcc cactgggcat cgtcggtggc ggcagcacag ggggtttgat
1075201 gaggtcgtcg ggcaatcccg ccagcacggc ggccaagttg taaccactca tccgaagctg
1075261 atcattgtct ccgttacgtg cgtactcaga gtgtccttat gctcgctcgt gaagttggcc
1075321 gtcgcccaag agcgggccgg gcgccaaacc ggtgttgacc gacagttgtg tcatgccggg
1075381 tacgtcctgg ggtgcggagc cgaatgcgcc gaattcgggg atggtattgg cgacatggtc
1075441 gttgacgccg atcatgtaga aggcatgccc tggctcaacg cccagctgcg acgcgtgcgt
1075501 gagctcggtg cccggtgaac cgtacaaaac gacgtcgctg accggtgccc cctgctgcag
1075561 cgccagactg gttaccaggg atccgtagga atgcccgaac gcggtgatgt gctgatcgct
1075621 gacattcgtg gtagcggcca agcctttgtc gaagcggttc aacggccccg cggcatcgcg
1075681 agccgaccag tcgtgcatca cgtctttgag gccgtccggc gcgtcatagc ccagccacgc
1075741 aatggatgcc accgcatcgt aatttggcca tccggctcgt tccctcagtt cggctgcctt
1075801 tgcgcgctga attccagctt ccttgaccat gtccccaacg ctcgaactca cccgcgtgtt
1075861 caggccgccc atcgtgacgc cgacgcgttc ggcgttgtcg acgtcgccaa ctcccacagc
1075921 cgccaacacc tttcgcgggt cactggcggt gtccaacaga atgaggctgg tgccgggatg
1075981 ggctgccaga gtatcccgca acgctcgcag atccgccagc ttgtcggtgt cggtgtgcca
1076041 gactccatct ctgctcaacc agccgttctg cagccgggtg agttctcgtt gcagcactga
1076101 aagattcagt tcgttgcgaa cggcgatggg aatgccgtcg cgattacgca gggtattggg
1076161 gaaccattgc ttgacccgat cctgctggcc cggggtcagc gaatgccacc accgcttgac
1076221 ctcctcaggg tcgctgtccg gcggcggcat ctgcggcatt gtgggtggcg catggctgag
1076281 ttgggcattg acctgctcgc gcgacaaggc cccggcggcg catcgaatcg ccgcggccag
1076341 atcctcatcg gcggtctcgg cgtcggccag cagacgtttg atgccctccg gattgcggtg
1076401 ttgaggatgg cctgctgatc ggccggggaa tacgacgaca agtcgggtgg tggcaacgcc
1076461 gtaccggtcg cgtaagcgat cgtcaggtga tgctcacgcg cggcatcgcg gatcacttgt
1076521 agccgcatct tgatcgcggc gacctcctcg gccgcctttt ccgcggcccg cgcgaccgct
1076581 tcacacgcgc cggcatggtg atcgagcagc accgttgtgt gatgggttgc tacctgtgcc
1076641 gcctcggcgg ccgcaccgcc aaagccgagc agccccatgg tgtcacgcag cgccgccgat
1076701 gcggtgcgtg tgccgtgcgc gcggtcgatc gcggcctgaa caccgtcctg atcgctgtgg
1076761 gatcccagcg ctcaatgtca gctaacgtca acgccgtcgc atcgggcgct tccaccgcct
1076821 gttggataaa ccgcggccag tgccgcggcg ttgtgttcct ccatctcggc gaacccgacc
1076881 gcggccagat gcatgccgta agaatggtcc ccgatgcggg ccgcgtgggc ggtgctggcc
1076941 tccgcccagc tatccagcaa tcccgacagc gcgcccgccg acgaaccgac ccatcccggc
1077001 cgcgcccctt cggccgcacc caggcagcag tggtgtgacg tcagcaaaga ctcgccgtgg
1077061 tcagcctgct gataaccgac ctgggacagg acttcaggaa tcgcccgcaa cgttctgcca
1077121 taccaactcg cttccacacg aaccaaactt tcggcggagt atggcacacg agcacattgc
1077181 gggcgattca cccgcatcga gctgaccggg cggcgcacct tgctatttgc ggctatttgc
1077241 gtggcttgcg gggtttgcgc ttgatgccca catcacccca cagcgagaag ccgcggatcc
1077301 tcaccgtcgg cacgccacgg gtgccctccc cgaccacctt gcggtcgaag ccgcccatca
1077361 ctcggtgacc gtggatctcc acgttgactt cgggtggcag cagaattgtc tgcgccccca
1077421 tgatcgagta cgcacggatg tccacctcgg tcgaggtgaa gtcggcgtag cgcagatcca
1077481 gcaccccgct gccccacaag gtgaacgtgg tcagcttctt cggcacgttc cagcggccgc
1077541 gtcgttcgaa tccgcccagt agcgccagca gcagcgtgga cggcgccgga ttgcattcgc
1077601 cacccctgcg cgggcctatc gccgcccccg gcagatcggc ccgcagccga tccagctcct
1077661 ggtaggtggt tgccgcatag gcccgcgcca gccggtcttc ataatcggtc agctgcaggc
1077721 ggccctgctc ggccgcgtag gccagcaact gcgcaatctg tatccggtcg gtgtccgacg
1077781 cacgcgcgga ctcgtcgcgc gagttcctcg cgtcacgctg cgccgagttg ctcatcgtcc
1077841 acgagcctac gacgtcaaga atttgcttca agaggtgttg gcgaaactgc aaatgttgcc
1077901 aggttcgact ccttgggtag cccaccccca gtggggtggg ataccatgaa cgggtgaggg
1077961 attaggggca agccatgagc aaggaattga ccgcaaagaa gcgcgcggcg ctgaaccggc
1078021 tgaagacggt tcggggccat cttgacggaa tcgttcggat gctggagtcc gacgcctact
1078081 gcgtggacgt gatgaagcag atttcagcgg ttcagtcctc gctggagcgg gccaaccggg
1078141 tgatgctgca caaccacttg gagacgtgct tttccacggc ggtgctggat ggtcatgggc
1078201 aagcggccat cgaagagctc attgatgccg tcaaattcac gccggcgctg accggtccac
1078261 acgcgcggct cggcggtgcc gcggtcggcg agtcggccac cgaggagccg atgccggatg
1078321 ccagcaacat gtgacgagcg ccggactccg gtgtttctcg ggacaacgac atacgaaagg
1078381 agcatccgcg atggtgtggc atggattcct agcgaaggcg gtacccaccg tggtcaccgg
1078441 cgcggtgggg gtcgcggcgt atgaggcgct gcgcaagatg gtggtgaagg ctccgctgcg
1078501 ggcggcaacc gtgtccgttg ccgcctgggg catacgctta gcacgtgaag ccgagcgcaa
1078561 ggccggggag agcgccgagc aagctcgact gatgttcgcc gacgtgctag ccgaagccag
1078621 cgagcgcgcc ggggaagaag ttccaccact ggcggtggcg ggttcggacg acggtcatga
1078681 ccactgacgt tctttctgac accgacgtct cgctgaaggt ggtctccaac gcgtcggggc
1078741 ggatgcgcgt gtgcgtcacc gggttcaatg tcgatgcggt tcgggccgtc gcgattgagg
1078801 agacggtctc ccaagtgacc ggggtgcacg ccgtgcacgc ctatccgcga acagcgtcgg
1078861 tggtgatctg gtactcgcca gagctcggtg acaccgccgc cgtgctgtcg gcgatcacca
1078921 aagcgcagca cgtcccggca gaattggtgc ccgcccgtgc cccgcactca gcgggtgtgc
1078981 gcggcgtggg cgtggtgcgg aaaatcaccg gcgggatccg ccgcatgcta agtcgcccgc
1079041 cgggcgtcga caagcccctg aaggcgtcgc gttgcggcgg ccgcccgcgc gggccggtcc
1079101 gcgggagcgc ctcgtggccg ggcgagcaga accggcgcga gcggcggacg tggttgccgc
1079161 gggtgtggtt ggccttgccg ttggggctac tggcgctggg ttcgtcaatg ttcttcggtg
1079221 cttacccgtg ggcggggtgg ctggccttcg ccgcgacgct gccggtgcaa ttcgtggccg
1079281 ggtggccgat tctgcggggg gcggtgcaac aggcgcgggc gttgacctcg aacatggaca
1079341 cgctgatcgc gctgggtacg ctgaccgcgt ttgtctactc cacgtatcag ttgtttgccg
1079401 gtggacctct gttcttcgac acctcggcgc tgatcatcgc gttcgtggtg ttgggccgcc
1079461 atctcgaggc cagagcaacc ggaaaagcgt ccgaggcgat cagcaagctg ctggagctgg
1079521 gcgccaagga agccacgctg cttgtcgacg gccaagagct cctggtgccg gtcgatcagg
1079581 tccaagtcgg agacctggtg cgggtgcggc ccggagagaa gatcccggtc gacggtgagg
1079641 tcaccgatgg gcgcgccgcc gtcgacgagt cgatgctcac cggcgaatcc gtcccggtcg
1079701 agaagacggc gggtgaccgc gttgccggcg caacggtcaa cctcgacggg ctgttgaccg
1079761 tgcgcgccac cgccgtcggg gcagacaccg cgctggcgca gattgtgcga ctggtcgagc
1079821 aggcacaggg cgacaaggcg ccggtgcagc ggctggccga ccgggtttcg gcggtgtttg
1079881 tcccggccgt catcggcgtt gccgtcgcga cctttgcggg atggaccctg atcgccgcca
1079941 acccggtggc tggtatgacc gccgcggtcg cggtgctgat catcgcgtgc ccgtgtgcgt
1080001 tgggcctggc tacccccacg gccatcatgg tcggcaccgg ccggggcgcc gaactgggga
1080061 tcctggtcaa gggaggcgag gtgctggaag cgtcgaagaa gatcgacacc gtggtgttcg
1080121 acaagaccgg caccctcacc cgcgcccgga tgcgggtgac cgatgtgatt gccggccagc
1080181 ggcgccagcc tgatcaggtg ctgcggctcg ccgccgcggt cgaatcgggc tccgaacacc
1080241 ccatcggtgc ggcgatcgtt gccgctgcac acgagcgcgg gttggcgata ccggccgcca
1080301 atgcgttcac cgccgtcgcc gggcacgggg tgcgggcgca ggtcaacggc gggccggtgg
1080361 tggtcggacg gcgcaagctc gtcgacgaac aacatttggt tctgcccgac cacctcgctg
1080421 cggcggccgt ggagcaggaa gagcgcggcc gcaccgcggt gttcgtcggc caagacggcc
1080481 aggttgtggg tgtgctcgcg gtagcggaca cggtcaaaga cgacgccgcg gacgtggtcg
1080541 gtcggctgca cgccatgggg ctacaggtag ccatgatcac cggcgacaac gcccgcacgg
1080601 ctgccgcgat cgccaagcag gtcggcatcg agaaggtgct ggccgaggtg ttgccgcagg
1080661 acaaggtagc tgaggttcgg cggctgcagg accagggccg ggtggtcgcg atggtgggtg
1080721 acggcgtcaa cgacgcgccc gccttggtac aagccgatct gggcattgcg atcggcaccg
1080781 gtaccgacgt ggccatcgag gcctccgaca tcacgctaat gtccggccgg ctcgatggtg
1080841 tcgtgcgcgc gatcgaactc tccaggcaga ccctgcgcac catctaccag aatctcggct
1080901 gggccttcgg ctacaacacc gccgcgatcc cactggccgc gctgggcgcg ctgaacccgg
1080961 tcgtggcggg cgcggcgatg gggttctcct cggtcagcgt ggtgaccaac tcactgcggt
1081021 tacgccgctt cggccgcgac ggccgaaccg catgatccat gacctgatgc ttcgttgggt
1081081 ggttaccggc ctgttcgtgc tgaccgccgc cgaatgtggt ctggcaatca tcgccaaacg
1081141 ccgaccgtgg acgttgatcg tcaaccacgg gttgcatttc gcaatggccg ttgcgatggc
1081201 ggtgatggcc tggccgtggg gcgcgcgggt tccgacgacg ggacctgcgg tatttttctt
1081261 gctggcggcc gtgtggtttg gggcgacggc cgtcgttgcg gtccgcggga ccgctacgcg
1081321 tggactgtac ggatatcacg gcttgatgat gctggccaca gcctggatgt atgccgccat
1081381 gaatcctcgt ttgctccctg tccgctcgtg caccgaatac gccaccgagc cggatgggtc
1081441 aatgccggct atggacatga ctgcgatgaa catgccgccg aatagcgggt cacccatctg
1081501 gttcagcgcg gtgaactgga tcggtacggt cggcttcgcg gttgcggcgg ttttctgggc
1081561 atgcaggttt gtcatggagc ggcggcagga ggcgacccag tccaggttgc cgggcagcat
1081621 aggccaagcg atgatggcgg ccggtatggc gatgttgttc ttcgccatgc tgtttccggt
1081681 ttgaggcagt tcgccgcctg tgtgtccgaa ccgcaaggta attcggaata ggctgttccc
1081741 aacctcctgc gtcgtaggcg ggggcccggc gggcctagtc agcggcccgc atcgtcgccg
1081801 gctggaccca gcggggcgga cgtttctgca ggaaggccag catcccttcg cgcgcttcgt
1081861 cggagacgaa cagcctggcc gactcctcgg tcaggcgttc ggcgtcgcgg tcgaaccctt
1081921 cgagcacggc ggccgtggtc agcgccttcg acgcggccag gccttgtggc gagccgcggc
1081981 ccacgtcggc gaccagcgcg gccaccgcgg cgtccacgtc gtcggccgcc atggtgatca
1082041 gtccgatgtc ggcggcttcg cgggcgccga acttctcgcc ggtcaggtaa tagcgggccg
1082101 cggcgcgcgg cgaaagcttg ggcagcagcg tcagcgagat gatcgccggt gccaccccga
1082161 tccgtgcctc ggtcagcgcg aacgtgcttt ccggtccggc gaccaccatg tcgcacgcac
1082221 cgaccaggcc gaacccgccg gcccgcacat gcccgttgat ggcgccgacc accggcagcg
1082281 gcgactcgac gatggcgcgc aacagcgccg tcatttcccg cgcccgcgcc accgccatcc
1082341 ggtacggatc accaccacca ccgccggcct cgctgaggtc cgcgccggcg cagaacgttc
1082401 cgccggtatg ccccagcacg accagccgca ccgccggatc tgcttcggcc gcactcagcc
1082461 cttgatgtag ttggctgacc agcgtgctcg acagcgcgtt gcggttgtgc ggagagttca
1082521 gtgtcagcct ggcgaagggg ccgccgcagg cggccgggcc agcgtagtcg acggggctgt
1082581 ccatcagtag gaccggggca gacccagcga tgtctgcgca acgaagttca gcaccatctc
1082641 gcggctgatc ggggcgatcc gcgccaagcg ggccgaggtc atcatcgctg ccacgccata
1082701 ttccttggtg aggccgttgc cgcccatcga ctgtacggcc tgatcgaccg cgcggctgga
1082761 tgcctcggcc gcagcgtatt tggccatgtt ggccgcctcg gccgcaccga agtcgtcacc
1082821 atggtcgtag agtgtggcgg ctttctgggt catcagcttg gcgagttcga cctcaatgtg
1082881 gcactgcgcc aacggatgtg ccaggccctg gtgcgcgccg atcggggtgg accacacctt
1082941 gcgggttttg acgtagtcga cggccctgcc gagtgcgaac cggcccatgc ccaccgcgct
1083001 agccgcaccc atgatgcgct cggggttcag gcccgcgaaa agctgtgcga tcgccgcgtc
1083061 ttcggctcca accagcgcat cggcgggtag ccggacgtcg tcgaggaaaa cctggaactg
1083121 gcgttcgggg ctgaccagct ccatctcgat cggggtgtag ctgaacccgg gagcgtcggt
1083181 gggcaccacg aacaacgcgg ggcgtagctt gccggttttg gcttcctcgc tgcggcccac
1083241 gaccagcacc gcctgcgcct ggtcgatgcc agaaataaag actttctggc ccttgatgat
1083301 ccagtcgctg ccgtcgcgac gcgcggtggt ggtgatcttg tgtgagttgg agccggcgtc
1083361 gggctcggtg atggcgaacg ccatggtcaa cgagccgtcg gcgatgcccg gcaaccagcg
1083421 cttcttctga tcgtcggtgc cgaacttggc gatgatggtt ccgttgatgg ccggtgacac
1083481 caccatcagc agcagcgccg agccggcggc ggccatctcc tccatcacca gcgacagttc
1083541 gtacatgcct gcgccgccgc cgccgtactc ttcgggcaga ttcaccccca aaaaaccgag
1083601 tttgcctgcc tcggcccata actcgctggt gtgttcgtgt ttgcgcgcct tgtccaggta
1083661 gtactcgtgg ccatagttgg ccacccaaga ggccaccgcc ttgcgcagcg cctgacgttc
1083721 ctcgctttcg ataaagctgg tgtctgtcac ggtgaatctc cttctgctgg gccattttga
1083781 ggtgcttcta ctcgtgcgag aatggcgcct acttcgacct gttgacccgt gttgacgctg
1083841 acgtgggtga gcacgccgtc ggcaggcgcg gcgatggtgt gttccatctt catggcctcc
1083901 agccagatca acggctgacc ggccgtgacc gtgtcgccaa cctcggcgcc gatccggatg
1083961 acgttgccgg gcatgggggc caccagcgag ccttgctcga cggccgagct cggctcgggg
1084021 aagcgtgaca gtgccaccag gtgaacgggt ccgcgcgccg agtcgacgta gacgtcgggg
1084081 ccgtggcggg caaccgtgaa gccgtgtgcg accccgtcct gggcgagcac cacctggtcc
1084141 acgtcagccg agaccagctg taccaccgga tcgccgggaa gcgccagacc cgttctggtg
1084201 aaccggtatt cgacgcggtg ttcggtgtcc gcgtcgtcac gataggtctt gacctgatag
1084261 cccgaggcca ggttgcgcca gccgctggga atcgagctga acacgcccgc gctcgcccga
1084321 ttgtgctcgg cgtcggccag cgcggcggcg atcgccgaca accggagggt cgcggtgtcg
1084381 gccagcggtg tcgacaactc ggccatgccg tgcgtgtcga aaaacccggt gtcggtggcg
1084441 ccgtcgagga acgccggatg acgcagcacg ttgaccaaga gctcacggtt ggtgcgcaga
1084501 ccgtgcagcc gggcgcgtac cagcgcatcg gccaacacaa gcgcggcctg ccggcgggtg
1084561 gcaccgtagg agacgacctt ggccagcatt gggtcgtagt ggatcgacac tgtggaaccg
1084621 tcgacgatcc cggaatccag ccggatgccg gtccgctgtc ccaacgagtc gaactgcgcc
1084681 cgaacccccg gaacctcaat cgtgtgcatc acgcctgcct gtggctgcca gccatgcgcg
1084741 ggatcctcgg cgtagaggcg ggcctcgatc gaatatccct gggcgggggg aggttcggtg
1084801 tcgagtcgcc cgcagtcggc aatcatgagc tgcagttcga ccagatccag cccggtggtc
1084861 tcttcggtga ccgggtgctc gacctgtagc cgggtgttca tctccaggaa gtagaactca
1084921 ccttcccggc caggtgagtc atcggcgagg aactccaccg tgcctgcccc ggtgtagccg
1084981 atcgcgctgg ccgccagccg ggccgcgtcg aacagcttgg cccgcatccc cggtacgcgt
1085041 tccaccagcg gcgacggtgc ctcttcgatg atcttctggt ggcggcgctg aatcgagcat
1085101 tcccgttccc cgaccgccca cacggtgcca tgggtgtcgg ccatgacttg cacttcgacg
1085161 tggtgcccgg tgggcaggta gcgctcgcag aatacggtcg ggtcgccgaa cgcggattgg
1085221 gcttcacgtc gcgcggcttc gacttcggcc ggcagggccg ataattcgtg aaccactcgc
1085281 atgccgcgac cgccaccgcc cgccgacgcc ttcaccagca ccggcagctg cgcggtggtg
1085341 acggcgtcgg ggtcgagttc ctcgagcacc ggcaccccgg cggcggccat cagcttcttg
1085401 gactcgattt tggagcccat cgcgcgcacc gcgtccaccg gtggcccgac ccaggttagg
1085461 ccggcctcct gcacggcggc cgcgaattcg gcgttctccg agaggaatcc gtagccggga
1085521 tgcaccgcgt cggctccggc tgcctgcgcg gccgcgatga tcgcctcggc gttcagatag
1085581 tcggtggtct gcggcagccg gacccgggcg tcggcctcgg cgacatgcgg tgccgcggca
1085641 tccgggtctg tgtagacggc gacggtgccg agccccagcc ggcggcaggt ggcgaacacc
1085701 cgccgggcga tctcgccgcg gttagcaacc aatactcgag tgattcccat cagcatcaca
1085761 tccggaagac gccgaagttc gacgtcccct tgatcgggcc attggcgatg gcggacaaac
1085821 acattcccag cacggtgcgg gtgtcgcgcg ggtcgatcac cccgtcgtcg taaagcatcc
1085881 cggacagcac caacggtagc gactcggctt cgatctggcc ctcgacggcg gcccgcatcg
1085941 ccgcgtcggc ggcttcgtcg acttgctgcc cgcgggcttc ggctgccgcc cgggccacga
1086001 tggacagcac gcccgacagc tgggcgccgc ccatcaccgc ggacttggcg ctgggccagg
1086061 cgaataggaa gcgcgggtcg taggcgcgcc cgcacatgcc gtagtgcccg gcgccgtagg
1086121 acgcgccgat cagcagcgag atgtgcggga cggtcgagtt ggacacggcg ttgatcatca
1086181 tcgagccatg cttgatcatc ccgccttcct cgtagtcctt gcccaccatg tagccggtgg
1086241 tgttgtgtaa gaacaacagc ggcgtgtcgg cccggttggc cagctggatg aactgggtgg
1086301 ccttctgtga ttcctcgctg aacagcacgc cgcgggcgtt ggccaggatg cccagcggat
1086361 agccgtgcaa ccgagcccag ccggtcacca gagacgaccc gtacagcggc ttgaattcgt
1086421 cgaactcgga gccatcgacg atgcgggcga tcacctcgcg cgggtcgaat gggatgcgca
1086481 gatccggggg cacgatgccg attagctcct cggcgtcgaa cagcggctcg gtcaccggag
1086541 cgggtgcggg tccctgtttg atccagttca gtcgcgccac gatgcggcgt ccgatgcgga
1086601 tcgcgtcgag ctcgtcgagc gcaaaatagt cggccaaacc cgatatgcgg gcgtgcattt
1086661 cggcgccgcc cagcgactcg tcgtcggact cttcgccggt ggccatcttc actagcggcg
1086721 ggccggccaa aaacaccttg gagcgttcct tgatcatcac cacgtgatcg gacatgccgg
1086781 ggacgtaggc accgcccgcg gtggagttgc cgaaaaccag cgcaatggtc gggatcccgg
1086841 ccgccgacag ccgggtcagg tcgcggaaca tctgtccgcc ggggatgaaa atctctttct
1086901 gggtgggcag atcggccccg ccggattcca ccagcgaaat gacgggaagc cggttttcga
1086961 aggcgatctg gttggcccgc agtatctttc gaagcgtcca cggattgctg gtgccgccct
1087021 tgaccgtcgg gtcgttggcg acgatcatgc attccacgcc gcagaccgcg ccgatgccgg
1087081 tgaccaggct ggcgccgatc tggaagttgc tgccgtaggc ggccagcggg ctcagctcca
1087141 ggaacgggga gtccgggtcg acgagcagct cgatgcgttc ccgtggtgtc aggttgccgc
1087201 gggcgtggtg ccggtcgacg tatttggggc caccgccggc gagcgccttg gccagttcgg
1087261 cgttgatctc gtcgagcttg ccgctcatcg tcgcggccgc ctcgtcgtag gcggaagcgt
1087321 tcgggtccag tgtggattgc agcacggtca cgattgatac cccagggttt tggcggccaa
1087381 agcggtcagt atttcggtgg tgccgcctcc gataccgagg attcgcatgt cccggtattg
1087441 gcgttcgact tcggattcgg ccatgtaacc catgccgccg aacagctgta cggcctggtt
1087501 ggcaacccac tccccggcct gcacggcggt gttcttggcg aaacacacct gcgcgatcag
1087561 gtcggtctcg ccggcgagct ggcgttccac cacatggtgc gcatagaccc gggcgacgtc
1087621 gatgcggcgg gccatctcgg ccagcgtgtt ctgcaccgac tggcgtgaaa tcagcggccg
1087681 accgaacgtc tcgcggtccc ggcaccactg cgcggtgagg tccaggcacc gctgggcgct
1087741 cgaatacgcc tgggcggcaa ggccgatgcg ctcggaaaca aatgcccggg cgatctgggt
1087801 gaagccgctg ttctcggcgc ccacgaggtt agtcgccggc acggccacgt cggtgtagca
1087861 cagctcggcg gtatccgagg aacgccagcc catcttgtcc agcttgcggg tcacctcaaa
1087921 gccgggggtg tccttttcca ccaccagcag cgaaaccccg gcggcaccgg gtccaccggt
1087981 tcgcaccgcg gtgaccacgt agtcggcccg cacgccggag gtgatgtagg tcttggcgcc
1088041 gttgatcacg taatggtcgc cgtcccgtac cgcgctggtc cgtagatgcc cgacgtcgga
1088101 gccgccgccg ggttcggtga tggccagcgc gccgatcttc tccccggcca aggtgggccg
1088161 cacgtacgtg gcgatcagcc gttcgtcgcc ggatgcgacc atgtgcggta cggcgatacc
1088221 gcaggtgaac agggacgcat acaccccgcc cggggcgccg gcctggtgca tctcctcgca
1088281 gatgatgacg gggtcggcgc cgtcaccgcc gccaccaccg accgcctcgg gaaagccggc
1088341 gcccagcagc ccggcggccc cggcgagccg gtgcaggccg cggggcaact cgccgatcct
1088401 ttcccactcg tcgacgtgcg gcaggatctc gcgctcggca aaggcgcgca ccgtttttcg
1088461 cagctgttgg cgctccggtg tggtccagat gttcacaaca gggtctccgg gatctcgacg
1088521 tggcggctgc gcagccactc acccagtccc ttggcctgcg ggtcgaagcg ggcctggtag
1088581 gcgacgccct ggccgaggat tgcctcgatg acgaagttca gtgcccgcag attcggcagc
1088641 acgtgacggg tgacgaccag gcctgccgtt tctggcagca gctccttgag tagctcgacg
1088701 gtcagcgtgt gcgccagcca gcgccactgc tcgtcggtgc gtacccacac gccgacgttg
1088761 gccgatccgc ccttgtcgcc gctgcgggcg ccagcgatca ggcccagcgg tacgcgccgg
1088821 gtcgggccag ccggcagcgg gtcgggcagc gccgggggat gtgccggcgc cagctccaac
1088881 gtctcagtgg cgcagggaat ctcggtgcgg gtgccgtcgg cgtgcacggc gatgtgcgcc
1088941 accttgccgg cgtcgacgta gccgggggtg aacacgccat acacctggcc gtcaccgggc
1089001 ggggcggtgg cggtgaaccc cgggtagctg gccagcgcca attcgaccgc ggccgaggag
1089061 aattgccgac ccacattggc agggtcggga tcgcgggcga cgcaggtgag cagcgcgctg
1089121 gcggtttctt cggtgtcggc gtcggggtgg tcggtgcggg ccagcgtcca ttgcagctca
1089181 gcgggtttga cggtcagcgc ggcctcgagc tggcgtcgca ccaagtcggc cttggcatcg
1089241 atgtccaggc cggtcagcac gaatgtcatg gcgttgcgga agccgccgat gctgttcagc
1089301 gacaccttgt aggtcggcgg cggcggttcg ccgatcacgc cgctaatgcg cactcgatcc
1089361 ggcccgtcgg gcgacagttc gacgctgtcc atccgggccg tcacatccgg gttggcatac
1089421 cgagcgcccg tgatctcgta gagcagctgc gcggtgatgg tgtcgacgct gaccaggccg
1089481 ccggtgccgt ggtgcttggt gatcaccgac gagccgtcgg cagcgatctc ggccagcggg
1089541 aagccggcgt gagtgaggtc gcctatctcg gtgaagaacg cgtagttgcc gccggtggcc
1089601 tggactccgc attcgatcac gtgcccggcc accacggcgc cggccagtcg gtggtagtcg
1089661 gtgcggcccc agccgaagtg cgcggccgcc gccccgacga ccaccgaggc gtcggtgacc
1089721 cggccggtga ccacgacgtc ggcgccgcgc tcgaagcagt cgacgatgcc ccatgcgccc
1089781 aggtaggcgt tggccgtcag tggcgtcccc agccccagtt cggccgcccg tggttgcagg
1089841 tcgtcgcctt ccacgtgggc gacctgcgcc ggaatgccca ggcgcgcggc cagcgcccgc
1089901 accgcgttgg ccagcccggc ggggttcagg ccaccggcgt tggtgacgat gcgcaccccg
1089961 cggtcatggg ccaggcccag gcagtcctcg agctgggcca ggaaggtctt cgcgtagccg
1090021 cgatcggggt ttttcatgcg gtcgcgaccg agaatcaaca tggtcagctc ggccaggtag
1090081 tcgccggtga gatagtccag ctcgccgccg gtcagcatct cgcgcatggc ggagaggcgg
1090141 tcgccgtaga agcccgagca gtttccgata cgcacggcac cacagtcagg gccatgcgat
1090201 tcctcccttg ggatcggcga cgctaccaac caaccggtag gttagcactg ccctgtttcg
1090261 cgacggagat cgcttcctga gtcgaagcgg cccggtctgc gccgtccatt ggagtagagt
1090321 ccgtttcgct acgggacgcc gggtgctttg ccggccccag gaggtcagcg ccatgtcctt
1090381 cgtggtcaca gcaccgccgg tgctcgcgtc ggcggcgtcg gatctgggcg gtatcgcgtc
1090441 catgatcagc gaggccaacg cgatggcagc ggtccgaacg acggcgttgg cgcccgccgc
1090501 cgccgacgag gtttcggcgg cgatcgcggc gctgttttcc agctacgcgc gggactatca
1090561 aacgctgagc gtccaggtga cggccttcca cgtgcagttc gcgcagacat tgaccaatgc
1090621 ggggcagctg tatgcggtcg tcgacgtcgg caatggcgtg ctgttgaaga ccgagcagca
1090681 ggtgctgggt gtgatcaatg cgcccaccca gacgttggtg ggtcgtccgc tgatcggcga
1090741 tggcacccac ggggcgccgg ggaccgggca gaacggtggg gcgggcggaa tcttgtgggg
1090801 caacggcggt aacggcgggt ccggggctcc cggacagccg ggcggccggg gcggtgatgc
1090861 cggcctgttc ggccacggcg gtcatggcgg tgtcgggggg ccgggcatcg ccggtgccgc
1090921 tggcaccgcg ggcctgcccg ggggcaacgg cgccaacggc ggaagcggcg gcatcggcgg
1090981 cgccggcggc gccggcggca acggcgggct gctattcggc aacggtggtg ccggcggcca
1091041 gggtggctcc ggcggacttg ggggctccgg cgggacgggc ggcgcgggca tggctgccgg
1091101 tcccgccggc ggcaccggcg gcatcggggg catcggcggc atcggcggcg cgggcggggt
1091161 cggcggccac ggctcggcgt tgttcggcca cgggggaatc aacggcgatg gcggtaccgg
1091221 cggcatgggt ggccagggcg gtgctggcgg caacggctgg gccgctgagg gcatcacggt
1091281 cggcattggt gagcaaggcg gccagggcgg cgacggggga gccggcggcg ccggcgggat
1091341 cggtggttcg gcgggtggga tcggcggcag ccagggtgcg ggtgggcacg gcggcgacgg
1091401 cggccagggc ggcgccggcg gtagtggcgg cgttggcggc ggcggcgcag gcgccggcgg
1091461 cgacggcggc gcgggcggca tcggcggcac tggcggtaac ggcagcatcg gcggggccgc
1091521 cggcaatggc ggtaacggcg gccgcggcgg cgccggtggc atggccaccg cgggaagtga
1091581 tggcggcaat ggcggcggcg gcggcaacgg cggcgtcggt gttggcagcg ccggaggggc
1091641 cggcggcacc ggcggtgacg gcggggcggc cggggcgggc ggcgcgccgg gccacggcta
1091701 cttccaacag cccgcgcccc aagggctgcc catcggaacc ggcgggaccg gcggcgaagg
1091761 cggtgccggc ggcgccggtg gagacggcgg gcagggcgac atcggcttcg atggcggccg
1091821 gggtggcgac ggcggcccgg gcggtggcgg cggcgccggc ggtgacggca gcggcacctt
1091881 caatgcccaa gccaacaacg gcggcgacgg tggtgccggc ggtgttgggg gagccggcgg
1091941 caccggcggc acgggtgggg tcggggccga cgggggtcgc gggggggact cgggccgcgg
1092001 cggcgacggc ggcaacgccg gccacggcgg cgccgcccaa ttctccggtc gcggcgccta
1092061 cggcggtgaa ggtggcagcg gcggcgccgg cggcaacgcc ggtggcgccg gcaccggtgg
1092121 caccgcgggc tccggcggtg ccggaggttt cggcggcaac ggtgccgatg gcggcaatgg
1092181 cggcaacggt ggcaacggcg gcttcggcgg aattaacggc acgttcggca ccaacggtgc
1092241 cggcggcacc ggcgggctcg gcaccctgct cggcggccac aacggcaaca tcggcctcaa
1092301 cggggccacc ggcggcatcg gcagcaccac gttgaccaac gcgaccgtac cgctgcagct
1092361 ggtgaatacc accgagccgg tggtattcat ctccttaaac ggcggccaaa tggtgcccgt
1092421 gctgctcgac accggatcca ccggtctggt catggacagc caattcctga cgcagaactt
1092481 cggccccgtc atcgggacgg gcaccgccgg ttacgccggc gggctgacct acaactacaa
1092541 cacctactca acgacggtgg atttcggcaa tggccttctc accctgccga ccagcgttaa
1092601 cgtcgtcacc tcgtcatcac cgggaaccct gggcaacttc ttgtcgagat ccggtgcggt
1092661 gggcgtcttg ggaatcgggc ccaacaacgg gttcccgggc accagctcca tcgttaccgc
1092721 gatgcccggc ctgctcaaca acggtgtgct catcgacgaa tcggcgggca tcctgcagtt
1092781 cggtcccaac acattaaccg gcggtatcac gatttctgga gcaccgattt ccaccgtggc
1092841 tgttcagatc gacaacgggc cgctgcaaca agctccggtg atgttcgact ccggcggcat
1092901 caacggaacc atcccgtcag ccctcgccag cctgccgtcc gggggattcg tgccggcggg
1092961 aacgaccatt tcggtctaca ccagcgacgg ccagacgctg ttgtactcct acaccaccac
1093021 cgcgacaaac accccatttg tcacctccgg cggcgtgatg aacaccgggc acgtcccctt
1093081 cgcgcagcaa ccgatatacg tctcctacag ccccaccgcc atcgggacga ccacctttaa
1093141 ctgacggccc ctccctggct cgtgataggg aaggggcgtc tgcagcgggc gttctcgatt
1093201 gtcgccgcgc tcatctgcgc gcggaagctc ataccaaaga ggaaggccca ccatggctgt
1093261 gcccacgcgc agaaagtcgc gcgcgaacac ccgaagccgg cgctcgcagt ggagggcccg
1093321 gccggacggg tgcgggccga acacaccggg cgggctggtg tcagctgatt accgacaccg
1093381 tgtcgccggc gaagttggtg acataaacct cgccggtgac ggggttgacc gccaccccgg
1093441 tcggagcggt gccgacggtg atgggggagc cggtgacggt gttggtggtc gggtcgatca
1093501 ccgacaccgt gttgctgtcg aagttggtca cgaagaccag gccggtgacg gggctgaccg
1093561 ccaccccgct tggaccgttg ccgatggtga tgggggagcc ggtgacggtg ttggtggcgg
1093621 ggttgatcac cgacaccgtg ccgctgccga aattggtgac gtagacgttg ccgcccgggt
1093681 tgaccgccac cccgtgcgga tcgttgaagc tggcgtgggt gatggtggtg acggcgccgg
1093741 cggccccacc ggcaccgccg accccacccg caccgccgat accgccgacc gggccgcggc
1093801 cggcaccgcc ggccgtgccg gcgcgggcga ggctgaccgc gccgccggtg ccgccggccc
1093861 caccgttgcc gatcaacccg gccgccccgc cggcgccgcc ggcctgtccg ggtgcccccg
1093921 acccgccgtt gccgccgttg ccccacagcc acccgccgtt accgccggct tgcccggtcc
1093981 cgtcgatccc gttcgcgccg tcgccgatca atgggcgccc ggtcagcgac tgaacgggtg
1094041 cgttgatcgc atcgagcacg ttctgcagcg gtgttgcgct ggccgcttcg gcgaccgcgt
1094101 aggtgctgcc agcttggctt aaggccagca cgaaccgttg ctgataggcc gcgacctgcg
1094161 cgctgatcgc ttgatagtgc tggccgtggc tgccgaacag cgcggcgatc gccgttgaca
1094221 cctcgtcttg ggcggcggcc aacacctggg tggtcgccgc cgccgcggtg ttggcggtgt
1094281 tgatcgccga gccgatccgc gctgcatcgg ccgcggctgt ggacactaac tgtggggcca
1094341 cgttgacaaa cgacatcgaa atcctcctga ccgccacgat gttgagatgc gggcggccca
1094401 ccgcctgtta ccgccgcggt gggtaaccgt ttattcggac gatccctgcc gttccacgcc
1094461 tgggcgcagg cgcaaaccgc accaacattg gtggaacgtg gtgcacactg cacctggggt
1094521 tctgccctca tcgtgtgtca gcaggcgaaa cccgcgcgga cgagaactcc tgcgttaagc
1094581 agcacaaatc gctgctcacg ctcaccggtc agcgcactga accggcccca tgtcgacgac
1094641 cggtgaggcg accgctcaac tcgtcggcgt caactcggcc attgccaccc tggtcgccga
1094701 ttcctgtccc acagccccac caccatcggg gcgacaaccg tgaactgacg gtcacgcccg
1094761 ggcccaaccc cggcccggaa ttgggccggg ccgtcttcaa ccggtatcct ccacgtcatt
1094821 gtcgacgcga ttgtcgccgc gcccacctgc gtgcggaagc ccataccaaa agaggaaggc
1094881 ccaccatggc tgtgcccaag cgcagaaagt cgcgctcgaa tacccgaagc cggcgctcgc
1094941 agtggaaggc cgccaagacc gagctggtcg gtgtgaccgt cgccggtcac gcccacaagg
1095001 tgcctcggcg cttgctcaag gccgcccggc tcggcctcat cgatttcgat aagcgctgac
1095061 gcgccggcgg ccgacgatca tatggccgcc gaacacaccg agcgcgccgg ctctccggtg
1095121 atcaccgaca ccgtgtcgtc gagagagtta gtgacgtaga ccacgccggt gacggggttg
1095181 accgccaccc ctgtcgggtc gagtccgacg gggatggggg agccggtgac ggtgttggtg
1095241 gccgggtcga tcaccgacac cgtgttgctg aactggttgg tgacgtagat gttgccgcct
1095301 gggttgaccg ccaccccata cgcaccggta ccgacgggga tggagccggt gacggtgttg
1095361 gtgttcgggt cgatcaccga caccgtgttg ctgtcgaagt tggtcacgaa gaccaggccg
1095421 gtgacggggc tgaccgccac cccgcttgga ccgttgccgt cggtgatgga gccggtgacg
1095481 gtgttggtga ccgggtcgat caccgacacc gtgttgctgc cctggttggt gacgtagatg
1095541 ttgccgcccg ggttgaccgc caccccgtgc ggatcgttga agctggcgtg ggtgatggtg
1095601 gtgacggcgc cggcggcccc accggcaccg ccgaccccac ccgcaccgcc gataccgccg
1095661 gccgggccgc cgccggcacc gccggcggtg ccggcgcggg cgaggctgac cgcgccgccg
1095721 gtgccgccgg tcccgccgtc cccgccgtgt ccacccacac cgattaaccc gccgtgacca
1095781 ccaaccccgc cggtgccacc gtcaccgccg gccacaccga aggttgtgcc ggctccgccg
1095841 gccccgccga caccaccggc cccgccgttg ccgaacagcc atccaccggc gccgccggct
1095901 ccgccgttcg cgccggcctc aaagggtagg ccctggccgc cagctccgcc ggccccaccg
1095961 ttgccgatca acccggccgc accgccggcc ccgccggcct gcccgggtgc ccccgacccg
1096021 ccgttgccgc cgttgcccca cagccacccg ccgttaccgc cggcttgccc ggtcccgtcg
1096081 atcccgttcg cgccgtcgcc gatcaatggg cgcccggtca gcgactgaac gggtgcgttg
1096141 atcgcatcga gcacgttctg cagcggtgtt gcgctggccg cttcggcgac cgcgtaggtg
1096201 ctgctagctt ggcttaaggc cagcacgaac cgttcctggt aggccgcgac ctgcgcgctg
1096261 atcgcttgat agtgctggcc gtggctgccg aacagcgccg cgatcgccgt tgacacctcg
1096321 tcgtgggcgg cggccaacac ctgggtggtc gccgccgccg cggtgttggc ggtgttgatc
1096381 gccgagccga tccgcgccgc atcggccgcg gctgtggaca ctaactgtgg ggccacgttg
1096441 acaaacgaca tcgaaatcct cctgaccgcg acgatgttga gatgcgggcg gcccaccgcc
1096501 tgttacccct gcggtgggta accgtttatt cggacgatcc ctgccgttcc acgcctgggc
1096561 gcaggcacaa accgcaccaa cattggtgga acgtggtgca cactgcacct ggggttctgc
1096621 cctcatcgtg tgtcagcagg cgaaacccgc gcggacgaga actcttccgc caagcagcac
1096681 aaatcgccct actcttgacc accaaacaaa acccgtccat ggggccaatg tggctgatgt
1096741 ggctaaacct cgtcgaacaa acccgcatac cacggcgcgc ctctcaggcc agtctcaggc
1096801 gctgcgacga cactggtgtc cgtgcgaatt cttgtcgttg acgacgatcg tgcggtgcgc
1096861 gagtcgctgc gccggtcgct ttccttcaat ggctattcgg tcgaactggc ccacgacggg
1096921 gttgaggcgc tcgacatgat tgccagcgat cgccccgacg cgttggtcct ggatgtcatg
1096981 atgccgcggc tggacggcct cgaggtgtgc cgtcagctcc gcggcaccgg cgacgacctg
1097041 ccgattctgg tgctgaccgc gcgcgactcg gtgtccgagc gggtggccgg gctggacgcc
1097101 ggtgccgacg actacctacc aaagccgttc gccctcgaag agctgctggc acggatgcgg
1097161 gcgctgctgc gccgcaccaa gcccgaggat gccgccgagt cgatggccat gaggttctcc
1097221 gacctgacgc tggacccggt aacccgcgaa gtcaaccgtg gacagcgccg gatcagcctg
1097281 acccgcaccg aatttgcatt gctggagatg ctgatcgcca atccgcggcg agtgctgacg
1097341 cgcagccgta tcctggaaga ggtatgggga ttcgactttc ccacctcggg caacgcgctg
1097401 gaagtctacg tcgggtatct acgccgcaag accgaggccg acggcgagcc gcggctgatc
1097461 cacactgtgc gcggagtggg ttacgtgcta cgtgaaacac caccctgatg tggtggttcc
1097521 gccgccgaga ccgggcgccg ctgcgcgcca ccagctcatt atccctgcgg tggcgggtca
1097581 tgctgctggc gatgtccatg gtcgcgatgg tggttgtgct gatgtcgttc gccgtctatg
1097641 cggtgatctc ggccgcgctc tacagcgaca tcgacaacca actgcagagc cgggcgcaac
1097701 tgctcatcgc cagtggctcg ctggcagctg atccgggtaa ggcaatcgag ggtaccgcct
1097761 attcggatgt caacgcgatg ctggtcaacc ccggccagtc catctacacc gctcaacagc
1097821 cgggccagac gctgccggtc ggtgctgccg agaaggcggt gatccgtggc gagttgttca
1097881 tgtcgcggcg caccaccgcc gaccaacggg tgcttgccat ccgtctgacc aacggtagtt
1097941 cgctgctgat ctccaaaagt ctcaagccca ccgaagcagt catgaacaag ctgcgttggg
1098001 tgctattgat cgtgggtggg atcggggtgg cggtcgccgc ggtggccggg gggatggtca
1098061 cccgggccgg gctgaggccg gtgggccgcc tcaccgaagc ggccgagcgg gtggcgcgaa
1098121 ccgacgacct gcggcccatc cccgtcttcg gcagcgacga attggccagg ctgacagagg
1098181 cattcaattt aatgctgcgg gcgctggccg agtcacggga acggcaggca aggctggtta
1098241 ccgacgccgg acatgaattg cgtaccccgc taacgtcgct gcgcaccaat gtcgaactct
1098301 tgatggcctc gatggccccg ggggctccgc ggctacccaa gcaggagatg gtcgacctgc
1098361 gtgccgatgt gctggctcaa atcgaggaat tgtccacact ggtaggcgat ttggtggacc
1098421 tgtcccgagg cgacgccgga gaagtggtgc acgagccggt cgacatggct gacgtcgtcg
1098481 accgcagcct ggagcgggtc aggcggcggc gcaacgatat ccttttcgac gtcgaggtga
1098541 ttgggtggca ggtttatggc gataccgctg gattgtcgcg gatggcgctt aacctgatgg
1098601 acaacgccgc gaagtggagc ccgccgggcg gccacgtggg tgtcaggctg agccagctcg
1098661 acgcgtcgca cgctgagctg gtggtttccg accgcggccc gggcattccc gtgcaggagc
1098721 gccgtctggt gtttgaacgg ttttaccggt cggcatcggc acgggcgttg ccgggttcgg
1098781 gcctcgggtt ggcgatcgtc aaacaggtgg tgctcaacca cggcggattg ctgcgcatcg
1098841 aagacaccga cccaggcggc cagccccctg gaacgtcgat ttacgtgctg ctccccggcc
1098901 gtcggatgcc gattccgcag cttcccggtg cgacggctgg cgctcggagc acggacatcg
1098961 agaactctcg gggttcggcg aacgttatct cagtggaatc tcagtccacg cgcgcaacct
1099021 agttgtgcag ttactgttga aagccacacc catgccagtc cacgcatggc caagttggcc
1099081 cgagtagtgg gcctagtaca ggaagagcaa cctagcgaca tgacgaatca cccacggtat
1099141 tcgccaccgc cgcagcagcc gggaacccca ggttatgctc aggggcagca gcaaacgtac
1099201 agccagcagt tcgactggcg ttacccaccg tccccgcccc cgcagccaac ccagtaccgt
1099261 caaccctacg aggcgttggg tggtacccgg ccgggtctga tacctggcgt gattccgacc
1099321 atgacgcccc ctcctgggat ggttcgccaa cgccctcgtg caggcatgtt ggccatcggc
1099381 gcggtgacga tagcggtggt gtccgccggc atcggcggcg cggccgcatc cctggtcggg
1099441 ttcaaccggg cacccgccgg ccccagcggc ggcccagtgg ctgccagcgc ggcgccaagc
1099501 atccccgcag caaacatgcc gccggggtcg gtcgaacagg tggcggccaa ggtggtgccc
1099561 agtgtcgtca tgttggaaac cgatctgggc cgccagtcgg aggagggctc cggcatcatt
1099621 ctgtctgccg aggggctgat cttgaccaac aaccacgtga tcgcggcggc cgccaagcct
1099681 cccctgggca gtccgccgcc gaaaacgacg gtaaccttct ctgacgggcg gaccgcaccc
1099741 ttcacggtgg tgggggctga ccccaccagt gatatcgccg tcgtccgtgt tcagggcgtc
1099801 tccgggctca ccccgatctc cctgggttcc tcctcggacc tgagggtcgg tcagccggtg
1099861 ctggcgatcg ggtcgccgct cggtttggag ggcaccgtga ccacggggat cgtcagcgct
1099921 ctcaaccgtc cagtgtcgac gaccggcgag gccggcaacc agaacaccgt gctggacgcc
1099981 attcagaccg acgccgcgat caaccccggt aactccgggg gcgcgctggt gaacatgaac
1100041 gctcaactcg tcggagtcaa ctcggccatt gccacgctgg gcgcggactc agccgatgcg
1100101 cagagcggct cgatcggtct cggttttgcg attccagtcg accaggccaa gcgcatcgcc
1100161 gacgagttga tcagcaccgg caaggcgtca catgcctccc tgggtgtgca ggtgaccaat
1100221 gacaaagaca ccctgggcgc caagatcgtc gaagtagtgg ccggtggtgc tgccgcgaac
1100281 gctggagtgc cgaagggcgt cgttgtcacc aaggtcgacg accgcccgat caacagcgcg
1100341 gacgcgttgg ttgccgccgt gcggtccaaa gcgccgggcg ccacggtggc gctaaccttt
1100401 caggatccct cgggcggtag ccgcacagtg caagtcaccc tcggcaaggc ggagcagtga
1100461 tgaaggtcgc cgcgcagtgt tcaaagctcg gatatacggt ggcacccatg gaacagcgtg
1100521 cggagttggt ggttggccgg gcacttgtcg tcgtcgttga cgatcgcacg gcgcacggcg
1100581 atgaagacca cagcgggccg cttgtcaccg agctgctcac cgaggccggg tttgttgtcg
1100641 acggcgtggt ggcggtgtcg gccgacgagg tcgagatccg aaatgcgctg aacacagcgg
1100701 tgatcggcgg ggtggacctg gtggtgtcgg tcggcgggac cggggtgacg cctcgcgatg
1100761 tcaccccgga agccacccgc gacattctgg accgcgagat cctcggtatc gccgaggcca
1100821 tccgcgcgtc cgggctgtcc gcgggaatcg tcgacgccgg gttgtcgcgc ggcctggcgg
1100881 gtgtctccgg cagcacgctg gtggtcaacc tcgcgggttc gcgttatgcg gtgcgcgatg
1100941 gaatggcgac gctgaatccg ctagcggcac agatcatcgg gcagttgtcg agcttggaga
1101001 tctgaatccg gatcgagtgt cgggctattg cgattctgtg ctcgcgcgag gcccgtcggt
1101061 tggcgatggt gtcccacggc cgccgtgcct ccccggcgag tccccgttcg tttgcgcgag
1101121 cagatcgcgg atttcggtga gcagcacgac ttgggtgtcg cccggctgct cgacctcccc
1101181 cttcttgcgt agtgtgttgt agggcagcac gactaggaag tacaccgcga acgcgatcag
1101241 gaaaaagttg atcgctgccg acaacaagac gttcaagtca atggtctgac caccgccgat
1101301 accgatccgc aagatgccga cgtcggactg tgcgttgacg ccgatccggt tgatcagcgg
1101361 cgtaatgatg ctgtcggtga acttggtgac caacgccgtg aacgctgtgc cgattaccac
1101421 cgcgacagcc aggtcgacga tattaccccg cgcgagaaac tccttgaatc ctttgagcat
1101481 gcgatgtcct ttctgcagtc ggcggccggc agtccgcgag tggaacacct agaaaaacta
1101541 gaccaggtgg tgtcaatggc cacgacgctg ggatcgccgt tgccatgggg agctgacgct
1101601 gccgggatcc ggtgctgttg tttgttgacg ggatgccctt gacttcgctg accgtggtgt
1101661 gcgcgtaacc ggccggtcgg gaacgcggcg acggatggcg cggtggccag gacagtgatc
1101721 gagatgacat cacgccaaca acgccttcag ctgtgagcga tccgggctag actaccgccg
1101781 aaatatccaa caaaggacct acatgaaccg gcaacctatc gttcagctga gtaacttgag
1101841 ctggacattc cgagaaggcg aaacccgacg acaagtccta gaccacatca ccttcgattt
1101901 cgagcccggt gagtttgtcg cgctgctggg gcaaagtgga agtggtaaaa gcactttgct
1101961 gaacctcatc agtggcatag aaaagcccac cacaggtgac gtcacaatta atgggttcgc
1102021 tatcactcag aaaaccgagc gagaccggac gttgttccgg cgcgatcaga ttggcatcgt
1102081 ctttcaattt ttcaacctga ttcccactct taccgtgttg gaaaatatta cgctgcctca
1102141 ggaactggcc ggagtttctc agaggaaagc ggccgtggtc gctcgtgacc ttctcgaaaa
1102201 agtgggcatg gccgaccgtg aacgcacctt tcccgataaa ctctccggcg gagaacaaca
1102261 acgggtcgct atttccagag cgttggcgca taatcccatg ctggtgttag ccgatgagcc
1102321 gaccggcaac ctggactccg ataccgggga taaagtcttg gatgttctgc ttgatctcac
1102381 ccgccaagca ggtaaaacct taatcatggc tacgcatagc ccgtcgatga cgcagcatgc
1102441 cgaccgggta gtcaacttac agggcggcag gttgatacct gccgtgaacc gagaaaatca
1102501 aaccgaccag ccggccagca cgatcctatt gcccacgtca tatgaatgac caagctcccg
1102561 ttgcttatgc accactatgg cgcacggcgt ggcgtcggct gcgtcagcgg ccgtttcaat
1102621 atattctgct ggtcctggga attgcgctag gcgttgccat gatcgtggct atcgatgtat
1102681 ccagtaattc ggcgcaacgt gccttcgatc tctctgccgc ggccatcacc ggaaaatcta
1102741 ctcaccggct ggtcagtggc cccgccgggg tggaccaaca gctttatgtc gatctgcgcc
1102801 gacacgggta cgatttttcc gctccggtaa tcgaaggcta tgtgttggcc cgcggactgg
1102861 gaaaccgagc tatgcagttc atgggcaccg acccatttgc ggagtcagct tttcgctcgc
1102921 ctttatggtc caaccaaaat atcgccgagt tgggtggctt tttgactcga cccaacggtg
1102981 tcgtgttaag ccgacaagtg gcacagaagt atggcttggc tgtgggcgat cgcattgctc
1103041 tgcaagtgaa aggtgcgcct accacagtaa ccctggtggg attgctgaca cctgcagatg
1103101 aagttagcaa tcaaaaattg tccgacctta tcattgctga tatttccacg gcccaagagt
1103161 tgttccatat gcccggaaga ctgagccaca tcgatttgat catcaaagat gaggccactg
1103221 caacacgcat ccaacaaaga ctgccggccg gtgtgcgtat ggaaacgtcg gatacccaac
1103281 gggacaccgt caaacagatg acggacgctt ttacggtcaa tttaaccgct ctcagtttga
1103341 ttgccttgtt ggtgggtatc tttttaatct acaataccgt gacatttaat gtcgtgcaac
1103401 ggcgaccgtt tttcgccata ttgcgctgtt tgggtgtaac ccgagagcag ttattttggc
1103461 tgataatgac ggaatccctc gttgccgggc tgattggtac gggcttgggc ctcttgattg
1103521 gaatttggct cggcgaaggc ttgatcggcc tggtgactca aaccatcaat gatttctatt
1103581 ttgtcatcaa tgttcgcaat gtgtccgtct ccgccgaaag cttgttgaag gggctgatca
1103641 tcggcatctt tgccgccatg ttagccacac tgccaccggc tatagaagcg atgcgcaccg
1103701 tccctgccag cacattgcgg cgctcctccc tggaaagcaa gataaccaag ctcatgccgt
1103761 ggttgtgggt ggcgtggttt ggtttgggta gctttggtgt attgatgctg tggttgccgg
1103821 gcaacaacct ggttgtggcc tttgtcggtc tctttagtgt gctgattgcc ctggcgctta
1103881 ttgccccgcc gctgacccgg tttgtaatgt tgcgcttagc tcctggctta ggacggctgc
1103941 tcggtccaat aggtcgaatg gcgccacgca atattgtgcg ctcgttgagt cgcacctcta
1104001 tcgccatcgc cgccctgatg atggccgtgt ccttgatggt aggcgtctcc atatcggtgg
1104061 ggtcgtttcg acagacgctg gccaattggc tagaggtgac tttgaagtcg gatgtctatg
1104121 tgtctccgcc gaccttaaca tccggtcgcc ccagcggtaa tctgcctgtg gatgccgtcc
1104181 ggaatataag caaatggcca ggagtgcgtg acgcagttat ggctcggtat agttccgttt
1104241 ttgccccgga ctgggggcgt gaggtggaac taatggcggt gtcgggtgat atttccgacg
1104301 gcaagcgacc atataggtgg atcgacggca ataaagacac gctctggcca cgtttcttgg
1104361 cggggaaagg ggtgatgcta tcggagccaa tggtatcgcg acaacacttg cagatgccgc
1104421 caaggccgat cacgctaatg acggattcgg ggccacaaac gttccccgtt ctggcggttt
1104481 tctctgacta cacctcagat caaggtgtga ttttgatgga tcgcgccagt tatcgggccc
1104541 attggcagga tgatgacgtg acgaccatgt ttcttttttt ggcatcgggt gcgaatagcg
1104601 gtgccttgat agatcaacta caagccgcgt tcgcgggtcg ggaagacatt gttattcaat
1104661 cgactcatag tgtccgcgaa gcatcaatgt tcatatttga tcgtagtttt accattacca
1104721 tcgcgttgca actggtggcc acggtggtgg cttttattgg cgtactgagc gcgctgatga
1104781 gtttggaatt ggaccgggct catgagttgg gtgtttttcg cgccattggc atgactaccc
1104841 gccaattatg gaagctgatg ttcattgaga ccggcctaat gggcgggatg gccggcttga
1104901 tggccttgcc aactggttgt attctagcgt ggattcttgt ccgcattatc aatgtccgct
1104961 cattcggctg gaccttgcag atgcactttg agtcggcgca ttttcttcga gccctgttgg
1105021 tagcggtggt ggccgccctg gcggcgggta tgtaccccgc ttggcgtttg ggacggatga
1105081 cgattcgcac ggcgattcgt gaggaatgac ggtacatgag aaaagcagga ttgaccggtg
1105141 ttgtactggt tctgacgctg acgctggtgg ctttctggtg gtggcaacgt ccgcgaacga
1105201 atgctgtggc tgctgactct ttagttggcg ttttggtcga tgagaataac gccggatatt
1105261 ccttggccac agtgccggga gccgttcggt ttccccggga tttgggtcct cattacgatt
1105321 accagacgga atggtggtat tacaccggta atctggaaac tgctgacggt cggcttttcg
1105381 gctaccagct tacttttttc cgcagggctc tcgcaccacc cggcgagggg gtcgccatag
1105441 cggatgcttc ttcatggcgc acgacccagg tctatatggc ccacttcgcg ataagtgata
1105501 tttcgaacag gggcttttat ccggctgaga aattcagtcg gcaggcgttg ggtttggctg
1105561 gtgctagctc ggagccgtat gcggtgtggc tagacgattg gtatgcgcgt gaatccaaca
1105621 acaattcggt gcaattgttt gctcgaactc agaacacggt gttggatttg acattgacgc
1105681 aaacgctgcc gcctatcttg caaggaaatg ctgggttaag tgtgaaaggc gcgcaaccgg
1105741 gaaacgcgtc caactactac tcgttagttc gtcaagaatc gcggggcact gtcagtgtta
1105801 atggcgacac attcatggtt agtggtttga gctggaaaga tcatgagtac atgaccagtg
1105861 cgctggcccc tgaagatgtg ggttgggatt ggttcgggct ccaattttac aatggcaccg
1105921 ctttgatgct ttttcagatt cgacaggcgg atgggagtgt gacccgattt tccagcggta
1105981 cctttgttgc cggggatggt ggcgtgatcc ctctcgagtc gtccgatttc cgcatcaaga
1106041 cgactgatcg ttggaccagt gaccagagtg gcgccaccta tccgattgca tgggaaatcg
1106101 aaattgaacg gataggtttg acgctgcgcg gggccgcatt aatggctaat caagaactgc
1106161 ggttatcgag gacttactgg gaaggggcgg ttgcccttga gggtcgttat caaggaatgc
1106221 cgatcagtgg tcggggatac gttgaaatga ccggctatgt acaacggctg tcttgaagtc
1106281 gggtaattgc cggtgattct tggtttagag gctctcgaat ggtcgtcggg cagttgtgat
1106341 atcgctgcaa accctagagt acttattcgt cgttgtgtca acaggtagtt gctggggtgt
1106401 gtcgctagtc gcacgcagat atcgcgtggt cgatcaatgt cgcaagggct cggcgaggtt
1106461 ggcggtcagg caaatagggg agctcctctc gcgcctgtgc ggcataggcg gctaccacat
1106521 tcttggcctt tcctatgccc ggtgagcaac gcagcagtgt gagggcttcg gcgacgtggt
1106581 cgtcgtggat cggtccggcc agcaactcac gcagccggct tgtgtcgggt gtctgctcac
1106641 gcagcgcgta gagcatcggc agcgtgtgga cagcttggcc aaggtcggcg cccgatagcg
1106701 tagcggagtc accggagatg gcgatgatgt cgcgcgagat ctcaaacgca gcaccgatca
1106761 tgcgccccaa gcgcgctacg cggcggatct gctcttcggc ggcgccggag agtgccgctc
1106821 cgagctgtcc ggatgctgcg atgagagagc cggtcttctc gtgcacgact cggaggtaat
1106881 gctcgatcgt gtcgatatgc gaggcggggc cccgggtcgc gcgcatctgc ccggtgatca
1106941 gctcggcgaa cgcctcggcg acgaccgcga aggcctcggg gtccagccgc gaggctagct
1107001 gtgaggccgt cgcgaatcgg tagtcaccgg cgaggattgc gaagttgttg gtccagcgtg
1107061 tgttgtcgct aggtgtcttg cggctcatgt cggactcatc cacgactctg tcgtgacaaa
1107121 gcgtccccag gtgcatcaac tcgatggctg cccccgcgac cgtgacctcc catccgtcgg
1107181 ggtcggagcc cagttgcgcc gcaagcaccg tgaaaagcgg tctaaacggg gtgccgccgg
1107241 cgtcgacaag gtgcgccacc gtgtcgcgca taacctcgtc ggcctgggag agttcgctat
1107301 tgatcagctc tgtaatccgg gcaatcccgt cgtggacgtt ggcggtgaat tgcgggtcac
1107361 ccaggctgac tgccgggatc atgctcgtgg ccgtaggcat gcgcacaaca ttgacacgtg
1107421 tacaagataa ggtatggcgt gttcagtgca gggtcagcgt caccgtctga cccagcgccg
1107481 caccggctac cgtattggcc agccgggctg gcagcgccac caaaacgacc cggtcactat
1107541 cagccgcctg ggccttctgc tgggccgaga ccaggaccac gatggcgtcg gtggccaaga
1107601 gccgtagagc tgccggcgaa tcggttaccg gcgcggccag cacgtcgacc acatccccga
1107661 cccgaacaag gtcgaccaaa gcgctgtcag ccagatgcag cggcacgatg cgggcgtccg
1107721 ggccggcagt cgactcggcc aaccggctgc ccagtaaacg cacgtcggtg agcacctcgc
1107781 cacggcgtgt cgggctggcc agcgtcgaac ccaccactgc gtccaggtca gcttgcgacc
1107841 cgtcgggaag cgtggtggcc gaacgttttt ccagcctgac atcaccggga gtcaatgcgg
1107901 taccggggcg cagatcgtgc gcggccacca ccacctcgga gcgatcatcc tctggattgg
1107961 accgcagcgc cgcaacgccg gccagcatga ccagcccggc cgcggcgaag cgccgggccc
1108021 gcacggtccg ggtccagtcc gggcgcaaaa acgccgatat ccggctgacc aggctcggat
1108081 tcagggagga ttccgccaca ccgcaaacgg taggcgcagc gccgtgctag gcagcgccgg
1108141 tcagaaatcc ccttgtggat aacctctcaa ctcagacggc cgcggcggcg gttgtggagc
1108201 tggttgactt ctcggttgac cccgaagcct tgctttcact cgagccagaa ctccccgaac
1108261 tccccgaact cttcgtcgac tcgctggtcg aggatccgtt ggtctggctc ttggacttct
1108321 tgcccgactc gcggctgtcg gtgcggtaga agccggtgcc tttgaacacc acgccgaccg
1108381 cattgaacag cttgcgcagc cggccagaac accgctcgca cgtggtcagc gcatcgtcgg
1108441 tgaaggcctg cacaacatcg aagcggttgg cgcactgggt gcactcgtag ctgtaggttg
1108501 gcacaagaac ctccggaaat gtcactcggc gttagcactc taccgtctca agtgctagaa
1108561 ccgctaggtg agttccgtca ttccccgcac ggcagcgcga tcagcccgcg ctccggtgtg
1108621 agcgcatgag tcatgggtac gtcgtgcggc tccgacggca acacgtcgac cagttcgaca
1108681 gtgcgcacca ccgcgactag acgagcgtgc gggtcgcggc accgcagcga gcgatcgtag
1108741 aagccgcgac ctcggcccag tcgcacgccc tggcggtcga cagccagcgc cggcaccagc
1108801 accaagctgg cctgcgccag cgcggcttcc ggcagccaag gttcgggtgg ttcgagcagt
1108861 ccccagcgtg cgcgcgcgag tccgccggca cggtactcgc cccaccgcaa cggcaacggg
1108921 aggtcaccgc cggcggtgcg cgccaccggc aacagcactc gccccgcgcg gcgcagcaac
1108981 acatccaaca tctcgattga ccccggctcg ccgcctaccg gcacatacgc gcagacggtg
1109041 ctgtcgctgg tgaccatgcg ctccaggtgt ccacgcaaca tccgggcctc ggcggcgcgc
1109101 acgtcgtcgg caacgcggcg tcgggccgcc aggagctggt cgcgcaacgc cgacttgctc
1109161 gccatcgcca tgtcctcaac gatgacacag ccccggccgt cccgcgcgag cgccgggaca
1109221 gcgccaacga agaggcgggc aatcagcacg ctgcgggtta tcgtgtgaac gatgtcacgc
1109281 ccagaagtac taacgccgtt cacggcaatc gtcccggcag ccggcctggg tacgcgcttt
1109341 ctgccggcca ccaagacggt gcccaaggag ctgctgcccg tcgtcgacac tcccggtatc
1109401 gagctggtgg ccgccgaggc ggccgcggcc ggtgccgaac ggctggtgat cgtcacctcc
1109461 gagggtaagg acggggtggt cgcgcatttc gtggaagacc tggtgctgga gggcacgctc
1109521 gaggcccgag gcaagatcgc catgctggcc aaggtgcgtc gcgccccggc actgatcaag
1109581 gtcgaatccg tggtgcaggc cgagccgctg ggactgggac acgccatcgg ctgtgtggag
1109641 ccgacgctgt cgcccgacga agacgctgtc gcggtgctgc tgcctgacga cctggtgctg
1109701 ccgaccggcg tcctggagac gatgtcgaag gtgcgagcca gcaggggcgg caccgtgctg
1109761 tgtgctatcg aggtggcgcg cgaggagatc agtgcctacg gggttttcga tgtcgagccg
1109821 gtccccgatg gtgactacac cgacgatccc aacgtgctga aggtcagggg catggtcgaa
1109881 aagcccaagg ccgaaacggc gccgtcgagg tatgcggcgg ccggccgcta cgttctagac
1109941 cgtgccatct tcgatgcgtt acgccgcatc gaccagggtg caggcggtga agtgcagctc
1110001 accgatgcga tcgcgctgct gattgccgag ggccatcccg tccatgtcgt cgtccaccaa
1110061 gggtcccgac acgacctggg aaatccgggc gggtacctca aggctgcggt tgactttgca
1110121 ttggatcgtg acgactacgg cccggacttg cggcgatggt tggtggcgcg actgggtctg
1110181 acagagcagt agcctggcga cgatacggca cggacggttc cggggtgggg gatgcccggc
1110241 cccatggctc gacggaaagg cgggcgctgt gcgttctgtg gaggagcagc aggctcggat
1110301 atcggccgct gcggtagccc cgaggccgat acgcgttgcg atcgccgagg cgcagggatt
1110361 gatgtgcgcc gaagaagtgg tcaccgaacg tccaatgccc ggttttgatc aggccgccat
1110421 cgacggctac gcggtgcgca gtgtcgatgt ggccggtgtc ggtgataccg gtggtgtcca
1110481 agtctttgcc gaccacggcg atcttgacgg tcgcgacgtg ctgaccctac cggtgatggg
1110541 aaccatcgaa gccggagcgc gcaccctgag caggttgcag cctcgccaag cggtccgggt
1110601 gcagaccggc gcgccgcttc ccaccctggc cgatgcggtc ctgccgttgc ggtggaccga
1110661 tggcggaatg tctcgggtgc gggtgctgcg cggggcgccg tcgggcgcct acgtgcggcg
1110721 tgcgggcgac gacgtgcagc ccggtgatgt ggcggtgcgc gcggggacga tcatcggcgc
1110781 agcccaggtg gggttgctgg cggcggtcgg ccgtgaacgg gtgctggtgc accctcgtcc
1110841 gcggctgtcg gtgatggccg tcgggggcga gttggtcgac atctcgcgga ccccgggcaa
1110901 cgggcaggtt tatgacgtca actcctatgc cttggctgcg gcgggccggg atgcctgtgc
1110961 ggaggtgaac cgggttggca tcgtcagcaa cgaccctacg gaacttggcg aaatcgtcga
1111021 gggccagctc aatcgggctg aggtcgtggt gatcgccggc ggggtgggcg gtgcggcggc
1111081 agaagcggtc aggtcggtgc tttccgagct cggtgagatg gaggtcgtgc gggtcgccat
1111141 gcatccggga tccgtgcagg gcttcggaca gctcggccgt gatggtgtac cgacctttct
1111201 gctgccggcc aacccggtca gcgccctggt ggtcttcgag gtgatggttc ggccgctgat
1111261 ccggctgtcg ctgggtaaac ggcatccgat gcgacggatc gtgtcggcgc gcacgctgtc
1111321 gccgatcacg tcggtggccg ggcgcaaggg ctacctgcgt ggccagttga tgcgtgatca
1111381 ggacagcggc gagtacctgg tgcaggcgct gggcggcgct ccgggggcgt catcgcacct
1111441 gctcgcgacg cttgccgaag cgaactgtct ggttgtggtt cccaccgggg ccgagcagat
1111501 tcgcacgggt gagatcgtgg atgtcgcctt cctggctcag cacggctgag ccgaaccacg
1111561 gcgactctgg tgaacttatg gcgctcgaat ccccggcatc cgggatggcc gatggccgtc
1111621 gggccgctgc gggtctcggc aggcgtgatt cggctgcggc cggtgcggat gcgtgacggc
1111681 gtgcattgga gccggatccg gttggccgac cgtgcacatc ttgagccgtg ggagcccagc
1111741 gcggacggcg agtggaccgt ccggcacacg gttgctgcct ggccggcggt gtgttcgggt
1111801 ctgcgttcgg aggctcgcaa cggccgcatg ctgccgtacg tgatcgagct ggatgggcag
1111861 ttctgcggcc agttgaccat cggcaatgtc acccacgggg ccttgcggtc ggcctggatc
1111921 ggctattggg taccaagcgc ggccactggc ggaggggtgg ccaccggagc gttggcgttg
1111981 ggtctcgacc actgcttcgg tccggtcatg ctgcatcgag tcgaggccac cgtgcgcccg
1112041 gagaatgcgg ccagtcgcgc cgtgctggca aaggttggct tccgcgagga ggggctgttg
1112101 cgccgttacc ttgaggttga ccgggcatgg cgagaccatc tgttgatggc gatcaccgtc
1112161 gaagaggttt acgggtcggt ggcctcgacg ctggtccgtg ccgggcatgc cagctggccc
1112221 taacgcggaa tcgcaaccaa actgtgactg gcgcgacacg tgtggcgtgt ggtgcttgtg
1112281 agagatgaat tacaggtgtg taattgccct gggcgctttg acccggccgc gctggccaac
1112341 gatggggcct cgcggggatc ggaaccgaag agagcaggtc atcatgccaa gcatcccgca
1112401 gtcgttgttg tggatatcgc tcgtggtgct ctggctgttc gtgctggttc ccatgctgat
1112461 cagcaaacgt gatgccgttc ggcgcaccag cgatgtggct ttggcgactc gggtactcaa
1112521 cggtggcgct ggtgcgcgcc tgctcaagcg aggtggtccc gccgcgggac atcgctgggg
1112581 gtacctcccg cccgaagggc agggggacga cccggactgg aagccggagg aagactggcg
1112641 cgacgacccg gtcgaggacg ggttcgccga cgtcgagcat gacatcgacg aggaccagga
1112701 ggccgacgat gcgcgccgtc ggggtgcggt tgtcatgaag gttgccgctc cgcagaccgc
1112761 aggtgccgac gagccggact acttagacgt cgatgtggtc gaagaagact cggaggcgct
1112821 tccggtgggg gctggcgctg cggtcggcga gtccgccgac gaggccgatg ccgaagctgc
1112881 tgacggagtt gcgggccacg ccgacccgga ggccgacccg gtcgaatacg aatacgaata
1112941 cgaatacgtc gaggacacct gcggtttgga gctcgaggag gacgaccagg aagcgccacc
1113001 gaccgtcgca tccggcacgt cacggcggcg ccgattcgac accaagaccg ccgccgcggt
1113061 cagcgcccgc aagtacacct tccgcaaacg tgcgttgatc gtgatggcgg tgatcctggt
1113121 tggctctgcc gccgcggcct tcgagctgac cccggtcgcg tggtggatct gtggtagcgc
1113181 caccggtgtg acggtgctct acctggcata tttgcgtcgg caaacccgca tcgaggagaa
1113241 ggtgcgtcgg cggcggatgc agcggatcgc gcgggcgcgg ctcggtgtag agaacacccg
1113301 tgaccgcgag tacgatgtgg tgccgtcgcg gctgcgccgt ccgggcgcgg tggtcctgga
1113361 gatcgacgac gaggacccga tcttcacgca cctggagagc gcggccccga tacggaacta
1113421 cggctggccc agggacctgc cccgggcggt gggtcagtag ggcgcgcagt tcggccatcg
1113481 gcgccgctgc tggtagcctg ctaccgatca ggggctatgg cgcagttggt agcgcgactc
1113541 gttcgcatcg agtaggtcag gggttcgaat ccccttagct ccaccatcta atcagtagcc
1113601 atcggcagcc tcgttggctg tgccgccgcg gacgtggttg agacggcgag cacagccctc
1113661 ggggcaatcc tggcaggtcg caatgcggtg gtgccgccac ggtgtccacg tcgaggcgcc
1113721 ggccttgtgg taccggtaaa gtgctgtggc gaccgcgatc tggcgcgaag cctgatgaag
1113781 atcgaatatt cggctgaata ttcgctaaga catgtgtggc ggcgtccgat cctgtcacaa
1113841 cctgccccta gggtcggtgc atgagcacga aatactacct gcagaaggtc cctgtcgaag
1113901 ccgtccagcc gggcttttcg ctggccattc cacacgatgg cgactatcgc cttttccagg
1113961 tcgactgcac gcaaatgtgc cagcgaagtg gccagccggt gatgatcaga ctcatgtcgg
1114021 agtccgtcga tggtggccag ccgtgggtct tggaatatga agcgggcacg gcggtaatcc
1114081 ggcttctcgg tgtttgccag gccgcttcgt agggtggcgt gtgctcgcta accgggcttg
1114141 gcggcggcta caaacggcaa cgcgcgttgt gtctactgct cgacgtccac tagcccggcc
1114201 gaccgagaca ggttgacgaa ggcattccgg tcaaacatcg tgagtccgat gttgccggcg
1114261 gcggcgttcg gcgcgtagcg catcggcggg cattggccgg catagctggt gtggatcgtg
1114321 atccgcccgg ctggccgcag cactcgcacc ttctcgcggg cgatccggaa cggttccggc
1114381 atcagctaca gcgcgccgaa acaacaaaca gcatcgaatg tttcgtcgcc gaatggcacc
1114441 atgcgggcgt ggccgcggat atgacacgtc cgtggcccac ggttgtccag ggcggtgctg
1114501 gtcagcgtcg gcgcagagat gtcgaacccg accgcaagac ccccgtccgg tggatgtccg
1114561 gacagcggct cagtgaaatt acctggccca caaccgatat cgagcactct gtgggcgcgg
1114621 ccgaggtgca gagacaccgc ggcgcggtgc cgctcggttc gggtggtgat gcggctggca
1114681 aggtggaagg aggccggacg ccacaaccgt tcgtacaacc gtaagctggg cttggcgccg
1114741 ggccggattg gacgggatag ccgaattgac cggcgcacga gtcgaagatc ttgcggggat
1114801 ggacgtcttt cagggatgtc cggccgaggg tctggtgtca ttggcggcga gcgttcagcc
1114861 gttgcgggcc gctgccggcc aggtgctgct gcggcagggc gagccggcgg tttcgtttct
1114921 gcttatctcg tcgggtagcg cagaagtcag ccatgttggc gacgatggtg ttgcgatcat
1114981 cgctcgggcg ctgccgggca tgatcgtcgg cgaaatcgcg ctgctgcgcg atagcccgcg
1115041 cagcgcgacg gtcaccacca tcgagccgct gaccggctgg acgggtggcc gcggcgcttt
1115101 cgccacaatg gtgcacatcc ccggggtcgg tgagcgattg ctgcgcaccg ccaggcagcg
1115161 tctcgccgcc ttcgtctccc cgattccggt acggcttgcc gacgggactc aactgatgct
1115221 acgccccgtg ctgcccggtg accgcgagcg gaccgtgcac ggacacatcc agttctccgg
1115281 cgagacgctg tatcgacggt tcatgtcggc tcgtgttccc agtccggcgt tgatgcacta
1115341 cctgtcggaa gtcgactacg tcgaccactt cgtctgggtg gtgaccgacg gaagcgaccc
1115401 cgtagccgac gcgcgttttg tgcgggatga aaccgatccg acggtcgccg agatcgcgtt
1115461 cacggttgcc gacgcgtatc agggcagggg gattggaagc tttctcatcg gtgcgttgtc
1115521 cgtggccgcc cgggtcgacg gcgtcgaaag gtttgccgcg cgcatgcttt ccgacaatgt
1115581 gccgatgcga acgatcatgg accgctacgg ggcggtgtgg cagcgcgagg acgtcggagt
1115641 catcaccacc atgatcgatg tgccgggtcc gggtgagctg agcttggggc gcgagatggt
1115701 cgaccagatc aaccgggtag cccggcaagt gatcgaggcc gtcggctgat caccgacccc
1115761 gggtcggtgc gtccgccgct ggcaccgcag ttcgccgctg atctgctagt caaaacggtg
1115821 tcgacgttgc gcagctcagg ggctgcgttg ggtagattga ccacgatgcg caaggcggta
1115881 ctggcagtcg gatcggtgtg ctggcttgtc ggctgctcat caggggccag ctccaccacc
1115941 gcctcgaccg gcgacatcgc caaggtggcc gaagtgaagt cgggctttgg acctgaatac
1116001 accgtcaccg atgtcactcc cagggccatc gatcccgggt tcttttccgc ccgcaaactg
1116061 cccgacgggc tgagtttcga tccggcgaac tgtgcgcaag tggcggccgg gccccagctg
1116121 ccgaccgggt tgcagggcaa catggccgcc gtctccgccg agggcaacgg caaccggttc
1116181 gtcgtcatcg cggtggagac gtcccagccg ctgccggccc ccagccccgg gaaagactgc
1116241 agcaaggtga ctttttccgg gacgcagctg cggggcggca tcgaggtggt cgatgtaccg
1116301 cacatcgacg ggacacagac gctgggcgtg catcgcgtgt tgcaggcggt cgtcggcggg
1116361 tcagcgcgca ccggcgagct ctatgactat tccgctcggt tcggggacta ccaggtgatt
1116421 gtcatcgcca atccactggt aatccctgga cggccggttg cgcgggtcga tacgcaacgc
1116481 gcccgcgatc tgctcgtaca ggcggtggcc gcggtccggg gttgaccgag ttagcggacg
1116541 tcgcgcggcc ggaactggat gctcacgcgc ggacccgtcg gcgccgatgt cttgggcacc
1116601 gcatgctcga aggtgcgttg acacgatccg cccatcacca atagatcgcc atgcgccaac
1116661 ggcagtcgca acgatggacc gcggccacgc ggccgcagcg cgaagacgcg ggtggcgccg
1116721 aggctgacga tcgccaccat agtgtcctca gtgctgccgc gaccaatggt gtcgccatgc
1116781 caggcgacgc tgtcagagcc gtcgcggtag tagcacagcc cggcggtggt gaagggctca
1116841 cccagttcgc cgccgtagat gtcgttgagc cgccggcgca tccgcgccag ctgcggatgc
1116901 ggcggatctt cgatggtcag gtcgtgaaaa ctcaccagcc gcggcacatc gaccacccgg
1116961 tcgtacatct gacggcgctc ggctcgccac ggcaccgtcg acaacaacgc gtccagcagt
1117021 tcttcgccgc cggtcagcca gcccgaacgg atgtcgataa aggctccgtc gccgagctgt
1117081 cttcgctcgt tgtgctcgaa gagcgcgcct tgaaccgcga tcgccacgcc gccaagctta
1117141 tcgcacattc gttcgatggc gccgccccgg ctacggtttg acctgtgggt gtcgaattgg
1117201 ggtcaaattc cgaggtcggc gcgctaagag tggtcatcct gcaccgcccg ggggccgaac
1117261 tgcgccggct cacaccgcgc aacaccgacc agctgctgtt cgacggcctg ccctgggtat
1117321 cccgcgcgca ggacgagcac gacgaattcg ccgagctgct ggcttcccgc ggtgcggaag
1117381 tgctgttgct gtcggacctg ttgactgagg cactacatca cagcggggcc gcccgcatgc
1117441 aggggatcgc cgctgccgtc gacgcaccgc ggctgggact gccgctggcg caagagcttt
1117501 cggcctacct gcgtagtctc gacccaggca ggttggcgca tgtgctgacg gccggcatga
1117561 ccttcaacga gctcccgtcg gacacgcgga ccgacgtgtc gttggtgttg cgtatgcacc
1117621 atggcggaga cttcgtcatt gagccgttgc cgaacctggt gttcacccgc gactcgtcga
1117681 tatggatcgg gccgcgggtg gtgatcccgt cgctggcatt acgggcacgg gtgcgcgaag
1117741 cgtcgctgac cgacctcatc tatgctcatc acccgcggtt caccggtgtg cggcgtgcct
1117801 atgaatcgcg caccgctccg gtcgagggtg gcgacgtgtt gttgctcgcc ccgggtgtgg
1117861 tcgctgtcgg agtgggcgag cggactacac cagcaggcgc ggaagcattg gcgcgcagcc
1117921 tttttgacga tgatcttgcg cataccgtgc tcgccgtgcc gatcgctcag cagcgcgcgc
1117981 aaatgcatct ggacacggtg tgcacgatgg tcgacaccga tacgatggtg atgtacgcca
1118041 acgttgtcga cacgctcgag gcgttcacga tccagcgcac acccgacggc gtgaccatcg
1118101 gcgatgcggc cccgttcgcg gaggcggctg ccaaggcgat gggaatcgac aagctgcggg
1118161 taattcatac cggaatggac cccgtcgtcg ctgaacgcga acagtgggac gacggcaaca
1118221 acacgttggc gttggcgccc ggtgtcgttg tcgcctacga gcgcaacgta cagaccaacg
1118281 cccgcctgca ggacgcgggc atcgaagtgc ttaccatcgc cggctccgaa ttgggtaccg
1118341 gccgtggcgg gccccgctgc atgtcctgtc cggccgcccg cgatccgctt taggagtggc
1118401 gatttcggcg cctggcggcg ccgcagatca ccgccagctg ggcagccaga tctccaggtt
1118461 ccaggtctgt tgtgagattg gcagaccggt gagcaccgga tacagccacg caaagttcgt
1118521 caccacgagg gccacgtagc agcagacgac gatcagcccc agtgtgcgtc gttcggagcc
1118581 ctgaccgggg tgatagagga tatcgccgag aaccagcgaa atgcccatca ccagaaatgg
1118641 cgccatggtc gctgcgtaga agaagtacat ctgccggtcg atgtcggcga accacggcag
1118701 ccaaccggcg cagtagccga ccaggaccac cgcataacgc cagtcccggc gcacaaacat
1118761 acgccacccc gcgtatgcca ggactggcac cgccagccac cacatcgcgg gcgtgccgac
1118821 cagcatctcg gccttgacgc acgactgtgc gccgcagcct gcaacgtctt gctggtcgat
1118881 ggcgtacagc accggccgca acgacatggg ccaggtccac ggtttggatt cccaagggtg
1118941 gtagttgcct gcggaattcg tcaggcccgc gtggaagtgg aacgctttgg cggtgtagtg
1119001 ccagagcgag cgcacggcgt cgggcagcgg aacaaccgag ttgcgaccga ccgcttgacc
1119061 gaccgcatgc cgatcgatcg cggtctcgga cgcgaaccac ggagcgtagg tggccagata
1119121 gaccgcgaac gggatcaacc ccagcgcata cccgctggga agcacgtcac gccgcactgt
1119181 ccccagccac ggtctttgca cttggtactg acgtcgcgcc gccacgtcga acgccagcgc
1119241 catcgcgccg aagaacagca cgaagtacac gccggaccac ttggtggcgc aagccaatcc
1119301 cagcagcacc ccggcgccga accgccacca gcgcacaccc acccgcggtc cccacacggt
1119361 ggcggcgctg cggccggcca gcagagcgat gtgcatccgt tcgcgaacct gatcgcggtc
1119421 gacgatgagc gcgccgaacg ccgcgacgac gaagaacgtc aggaagccgt ccagcagcgc
1119481 ggtccgcgcg gtgacgaagc tgaccccgtc gcagatcagc agcaccccgg cgatggcgcc
1119541 gaccaatgtc gaccggctga tccgccgcac gatccgcacc accagcgcca ccaggaccac
1119601 acccagcagg gcgccggtga accgccagcc gaatccgttg taaccgaaga tggcctcccc
1119661 gatcgcgatc agctgcttac cgaccggcgg gtgaaccacc aggccgtacc cggggttgtc
1119721 ttccacccca tggttgttca gcacctgcca ggcctggggt gcgtaatgct tctcgtcgaa
1119781 gatgggggtg ccggcatcgg tcagcgagcc caggttcagg aaccgggtca ccgtggccag
1119841 cagcgtgatc aggccggtca cgatccagcc gcgtaaccgg tccaggggcc cgaaatccgc
1119901 gaccggcacc agcgggccgg ggctgacgac gggtaccaca ggctcctcgg ggcggtcctt
1119961 ggccaggaca caggattctg ggggccgggc ggtcatcggt gtcgatcgta ggctgtccgt
1120021 catgtcctct ggtcgcctgt tgctcggcgc caccccgctg ggccagccgt cggatgcgtc
1120081 accacgcctg gcggccgcgt tggccaccgc cgatgtggtg gcggccgagg acacccggcg
1120141 ggtgcggaaa ttggccaagg ctcttgacat ccggattggt ggacgggtgg tcagcctgtt
1120201 cgaccgggtg gaggcgttgc gcgtgacggc ccttctcgac gcgatcaata acggtgcgac
1120261 ggtgctggtg gtcagtgacg ccgggacccc ggtgatcagc gatcccggct atcggctggt
1120321 cgcggcgtgc atcgacgcgg gggtttcggt gacgtgttta cccgggccgt ccgcggtgac
1120381 caccgcgctg gtgatgtccg gtctgccggc ggagaagttc tgcttcgagg gtttcgcccc
1120441 gcgcaagggt gcggcgcgcc gggcctggct ggccgaactg gccgaggagc ggcgcacctg
1120501 tgttttcttc gaatccccgc gccggttggc tgcgtgcctt aacgatgccg tcgagcagct
1120561 cggtggtgcc cgtccggcgg cgatctgccg ggagctgacc aaggtgcatg aggaagtggt
1120621 gcgcggatcg cttgacgagt tggcgatctg ggcggccggt ggtgtgctcg gcgagatcac
1120681 cgtggtggtg gcgggcgccg ccccccacgc cgaactgtcg tcgctgatag cccaagtgga
1120741 ggagttcgtc gcggcgggta ttcgtgtcaa ggacgcctgc agcgaggtag cggcggcaca
1120801 tccgggggtg cgcacccgcc agctttacga cgcggtgctg caatcacggc gggaaaccgg
1120861 cgggccagcg cagccgtagt cggtcaggtt aggggataca caccccgatg ggaccgaatc
1120921 cgggtgtgca cagacgcgac gggagcgccg gcagcggagg cggtcccggc agtgggggag
1120981 gtgccggcaa tgcgggcacg gccggtaacg gcggcagacc cgctggcagt gccggcaggc
1121041 cggccgccag cgccggcagc gccgcagcca gcgccgcagg atccacgcct ggcagcgccg
1121101 ggaggcccgg cggtagacca cctgccgcca gcgccggcag cgccgcagcc agcgtcgccg
1121161 gatccacccc cgccagacca gccggcagac cagcggccgc cagcatcggc agaccacctg
1121221 ccaccagcgc cgtcagctcc gccggcgaca tccccgccag acccggcaaa ctcgtcggca
1121281 gaccggccgc ggccgccatc gccatcaggt cggtcggcga cacacctggc agactcggaa
1121341 aacccacgcc tggcaggccg gcggccgccg ccatcgcgag cagactcgcc ggcgtcacgc
1121401 ccggcagggc gggcagcccc acagccggca gagcggccgc cgccgattgc gccccgggca
1121461 gcagcaggga ggccaccgtg ctggctgttc cgcgggccgt cggcaggatg ccggaagact
1121521 ccagcgcgtt aaccgcaagc acgagatagg tgacggccac cgcgctcgcg gtcaccaccc
1121581 ccgccgccgt gcctcccaca cccaggacac cgttcacgac cgcggcagcg gtgttcaccc
1121641 cggtgattgg gtcgggtacg ccggggatgc cgatgcccgg gatgccgatg cccgggatgc
1121701 cgatgcccgg gatgccgacg ccaggtacgc tcggcgcggc caggttcggc agggccggtg
1121761 ggggaggcag ggccgggccg gccgcaccgg gaatgttggg taggccggga acggctggcg
1121821 ggcccaccct gggcacggcg gcagccgccg gtacacccgg ccgcggaacc aatcccggcg
1121881 cgatcgtgtc ggcgaccggc tcgaacggcg ccggcaccgc gtgctccgct gcggccggcc
1121941 ccgatggtgt cgcggtgtcg ggcatcagga ccgcagccag ccgatcgcac tgctggccgg
1122001 cgctgcaggt gccgcccgcg acccgctccg gggtggacaa cgtcaacggt gccaccgcca
1122061 gcgttccccc tatcgcggca gcagccgcgg tgcccacgat cgcgagtctc attacaaacc
1122121 cctctcgaac tcgacacgag atagacacgc gtcgatggcc cgagcttagg cgcacccggc
1122181 acaccatgtg ggcgttatgc caatttccgc cgcccgctgg gctaccgcac tttgctggct
1122241 aaccgagccg gggtggtgcg cgtggcggcc ggcagcccga cgatgggagc ggctttgtgc
1122301 aggcactccg cccattcggc gtccggatcg gagtcggcgg tgatcccgcc gccaacgccc
1122361 agcacggcgt tgcctgcggt atcgaattcg acggtgcgga ttgcgacgtt gagctcgcat
1122421 ccggcgaccg gtgacgccaa accgactgtg ccgcaatata tcccgcggcg atatcgctcc
1122481 cattgtgaaa tcaattggcg agcccgcagt ttaggtgtgc cggtgaccga ggccggcggg
1122541 aaggcggcgt cgagcagcgc tgacatcggt tcctcgagcg gaacccgcgc cgacaccgtg
1122601 gacaccaggt gccacactcc cggcgctggt cgcaccacca acagctcggg caccgtcacg
1122661 gtaccggtaa ccgctacccg gccgaggtcg ttgcggacca gatccacgat catgatgttc
1122721 tcggccacct ctttggccga tgcccgcagc gccgacggcg gggcgtccag cggcagcgtg
1122781 cccttgatcg ggctcgatgt caccacggac ccgcggcggc gcaggaatag ctccggggat
1122841 agcgatgcga cggctcccca cggtccggcg acaaaggcgg accgggacgg agcggtacga
1122901 ccgaacccgt cgatgaagaa gtccagcggg gatccggtga ccgtcccggc gaattgggtg
1122961 cacacgcacg cttgatagac ctcgcccgcg ccgatagctt ccagacacgc cagtaccccg
1123021 tcgcggtgcg ctgcccggtc ggccggttcc cagtcgatcc ggcatgccgg tgccggtctg
1123081 gcgaccgatg cccgagtggt cgccaacgcg ctggccagcc agtccgctat cggcgcaccg
1123141 gacaggctct cataccacca ctggccgtcg cggtcgcggc gcagcacgca atcggtccag
1123201 ccgccggcgg cctcggggat ccggtggggt cgcccgtcgg cgccggcgtc cgggtaggac
1123261 aggtagccga cccagccgcc gcccaccgcc ccggtggcat cgggcccgcc ggtgcccggc
1123321 gggcccgaga acacgtcgtc gccgctgacc ggttgtatag acacactcgg tgcgatcacc
1123381 gccagcgcac cgaaccattc gccggtcagc gccgccggtg gtggcaagtc gagtcgactg
1123441 gtggcgcggc cgaccgcccg cagcaccgca ggcgctccgc caagatcgcc gagtcggtcg
1123501 attcgcaccg ttctagcttg acagaactgt ggattttcgc agcgcaagtg gctgcgtggg
1123561 gatttcgtcc gcgtgctaag ctcccacgct aagttcaatc cgtgaccggc tccggtctcc
1123621 gtcccggggg gtgttgctgt gcgagcagcc aatgccaatg ccgtttctcg ctgaccgcga
1123681 gacgttgacg ctcggtgtga tcttgaagta gcgatggttt taagaagtag gaaaagcacg
1123741 ctcggcgttg tcgtgtgctt agcgctggtg ctcggtgggc cgctcaacgg ttgcagcagc
1123801 agcgcgagcc accgcggtcc actgaacgca atgggaagtc cggccatacc gtcgacggcg
1123861 caggagatac ccaacccgtt gcgcggtcag tacgaagacc tcatggaacc gctgtttccg
1123921 caggggaacc ccgcgcagca acgctatccg ccttggcccg cgtcctacga cgcgagtttg
1123981 cgagtctcct ggcggcagct gcagcctacg gatccgcgca ctctgccccc ggatgctccg
1124041 gacgaccgca agtacgactt cagcgtgatc gacaacgcgt tgaccaggct cgccgaccgc
1124101 ggcatgcggc tgacgctgcg ggtgtacgcc tacagctcgt gctgcaaggc ttcctatccg
1124161 gacggcacta acatcgcgat tcccgactgg gagcgcgcta tcgccagcac caacaccagt
1124221 tatccagggc cggcgaccga tccctcgacc ggggtggtgc aggtggtgcc gaatttcaac
1124281 gattcgacct atcttaacga ttttgcgcag ttgctcgccg cgcttggtcg ccgctacgac
1124341 ggtgacgagc gcctcagcgt gttcgagttc tccgggtacg gggacttcag cgaaaatcac
1124401 gtcgcatacc tgcgcgacac gctcggtgcg ccgggtccgg gcccggatga aagcgtggcg
1124461 accctgggct attacagcca gttccgtgat cagaacatca ccaccgcgtc catcaaacag
1124521 ctaatcgcgg cgaacgtcag cgccttcccg catacccaac tggtgaccag tcccgctaat
1124581 ccggaaatcg tgcgagaact gttcgccgac gaggtcacca acaagcttgc cgcgccggtg
1124641 ggtgtccgct cggattgcct gggcgtcgac gcgccgttgc cggcctgggc cgagtccagc
1124701 acttcgcact atgtgcagac caaagacccg gtggtcgccg cgctgcggca gcggctggca
1124761 acggcgccgg tgatcaccga gtggtgcgag ttgccgaccg gcagttcgcc gcgggcttac
1124821 tacgagaagg gcctgcgcga cgtcatcagg tatcacgtgt cgatgacgtc gagcgttaac
1124881 ttccccgacc agacggcgac ctcgccgatg gaccccgcgt tgtacctggt gtgggcgcaa
1124941 gctaacgccg ccgcaggcta tcggtactcg gtcgaagcgc agccggggtc gcaagcgcta
1125001 gcgggcaagg tcgcgacgat ctcggtcacc tggaccaact acggcgctgc tgccgccacc
1125061 gaaaagtggg tgcccggcta ccggctggtg gattccaccg gacaggtggt tcggacgctg
1125121 ccggcagcgg tggacctgaa gacgctggtc tccgaccagc gcggcgatcg cagcagcgac
1125181 cagccgacac cggcgtcggt cgccgagacg gttcgcgttg atctgtccgg cttgcccgcg
1125241 ggccactaca cgctgcgggc cgcgatcgac tggcaacagc acaaaccgaa cggctcccat
1125301 gtggtgaact atccgcccat gctgttgtcc cgcgacggcc gcgacgattc cgggttttat
1125361 cccgtcgcca cgctcgacat cccacgcgac gcgcagaccg cggtcaacgc ttcgtaggtg
1125421 gctttcccgt cgctgcggtc cgctcacttg ccttcgggtg gttgcggcgg ctggtagcgg
1125481 ggaaataccc cggtgggcgg cggcagcgct gtgccggggg tcagccgaac acctacggcg
1125541 gcgaacgacc gctggtttgg ggcctggccg agcaggtcca aaattttgcc ggccgactcc
1125601 ggcatcaccg gctggatcag cagtgccgcg atgcggacta cctcgcaggt gacgtagagc
1125661 gtggtgcgga accgggcctg atcggcttcg gactcgctct tgcgcagtac ccacggctgc
1125721 tgcaccgaaa agtacttgtt cgcgtcgccg agcatcagcc agatcgcctc cagcgccagg
1125781 tgcatcgcct gtgcgtcgaa gtgaccgcgc actcgctcca acaagccatc ggcggtcgca
1125841 agcagcgcgg cgtcggcgtc ggcgaactca cccgggttgg gcaccctgcc gtcaaggttt
1125901 ttggccacca tcgacaacga gcgttgggcc aagttgccga gctcgttggc cagatcggtg
1125961 ttgatccgag tgacgatggc ctcgtcgctg taactgccgt cctggccgaa cgggacctcc
1126021 cgcaacagga agtagcggac ctggtccacc ccgagcgctt ccgccagggc aaccgggtcg
1126081 acgatgttgc ccaccgattt actcatcttc tcgccgcggt tgtgcaagaa cccgtgcgcg
1126141 aagatccttc gcggcaactc gattccggct gacatcaaaa acgccggcca atagacggca
1126201 tgaaacctga tgatgtcctt gccgatcatg tgcaaatcgg cgggccagta gcggcggaac
1126261 aactccgagt cggtatccgg gaagcccgcc ccggtcaggt aattggtcag cgcgtcgacc
1126321 cagacgtaca tgacgtggtc ggggtgctcg ggcacctgca caccccagtc aaacgaggtg
1126381 cgcgagatcg acaggtcgtc caggccgccg gagacgaagc tgatcacttc gttgcgccgc
1126441 gtctccggcg cgatgaagtc ggggttggcg tgatagtggg ccagcagctt gtcggtatag
1126501 gccgacagcc ggaagaagta ggtctgctcc tcggtccagg tcaccggcgt gccggtctct
1126561 accgtcaggc gcgtgccgtc gacaagttgg gtctccgatt cgacgaagaa ccgctcgtcg
1126621 cgcaccgagt accacccgga atagttgtcc agatagatgt cgccggccgc cgacatccgt
1126681 cgccagagtt ccttggacgc ctcgtggtgg tcggcatcgg tagtgcggat gaatcggtcg
1126741 aaggagatgt tcagcgcctc ctgcatgcgc tgaaacacgt cggaattgcg ccgggcaagc
1126801 gccgcggtgg gcacgcccgc tgccgcggcg gcttgtgcga ccttcaggcc atgctcgtcg
1126861 gtcccggtca ggaagcgcac gtcatagcga tccagccgtt tgaaccgggc gatcgcgtcg
1126921 gtggcgatgt attcgtaggc gtgacctacg tggggtgcag cgttgggata tgcgatcgcg
1126981 gtggtgacgt aatagggctt catttcgaca ccaccctatt gtgtgcgggt gagctccgac
1127041 cgcccagcca gacgagatcc accgcccgct ccggaacccc tggcgccgtt ggtcgacgcc
1127101 cacacccatc tcgacgcgtg cggtgcacga gacgccgata cggtgcggtc gctcgtcgag
1127161 cgagccgccg cggccggcgt gaccgcggtg gtcaccgtcg ccgacgacct ggagtccgcg
1127221 cgctgggtca cccgcgcggc cgaatgggat cggcgagtct atgccgcggt ggcgttgcac
1127281 ccgacccgcg ccgatgcgct caccgacgct gcccgtgccg agctcgagcg attggttgcc
1127341 caccccaggg tggtggccgt cggtgagacc ggaatcgaca tgtactggcc gggtcgcctg
1127401 gacgggtgtg cggagccgca cgtccagcgg gaggcctttg cctggcatat cgatctggcc
1127461 aagcggaccg gtaaaccgct gatgatccac aatcgtcagg ccgaccgcga cgtgctggac
1127521 gtgctgcggg ccgagggcgc gccggacacc gtgatcttgc actgcttctc gtcggacgcg
1127581 gcgatggccc gcacgtgtgt ggacgccggg tggctgctca gcctgtccgg gacggtgagc
1127641 ttccgtaccg cccgtgaact acgggaagcc gtcccgctga tgccggtgga gcagcttttg
1127701 gtggaaaccg atgcaccgta tttgaccccg catccccacc ggggcttggc gaacgaaccg
1127761 tactgcctgc cctataccgt gcgggcgctg gctgaactgg tcaatcggcg ccccgaagag
1127821 gtggcgctca tcaccacaag caacgctcgc cgagcttatg ggctagggtg gatgcgccaa
1127881 tgagcgcgcc gagcggccca taacacccgc gcgccggagt tgctcaacat tggccggttc
1127941 gttaccgtct tgtgatcgaa cgggtggggc ctctaggttt cggagggccc attttgcttt
1128001 ttgttcgctg tgtaggtggt tgagtgttgc cgaggtcggg gatatagcgc gttgactcta
1128061 cttaccaaac ttcatcagac ccaatcaccg atgttgcgcc tggtagtcgg tgcgctgctg
1128121 ctggtgttgg cgttcgccgg tggctatgcg gtcgccgcat gcaaaacggt gacgttgacc
1128181 gtcgacggaa ccgcgatgcg ggtgaccacg atgaaatcgc gggtgatcga catcgtcgaa
1128241 gagaacgggt tctcagtcga cgaccgcgac gacctgtatc ccgcggccgg cgtgcaggtc
1128301 catgacgccg acaccatcgt gctgcggcgt agccgtccgc tgcagatctc gctggatggt
1128361 cacgacgcta agcaggtgtg gacgaccgcg tcgacggtgg acgaggcgct ggcccaactc
1128421 gcgatgaccg acacggcgcc ggccgcggct tctcgcgcca gccgcgtccc gctgtccggg
1128481 atggcgctac cggtcgtcag cgccaagacg gtgcagctca acgacggcgg gttggtgcgc
1128541 acggtgcact tgccggcccc caatgtcgcg gggctgctga gtgcggccgg cgtgccgctg
1128601 ttgcaaagcg accacgtggt gcccgccgcg acggccccga tcgtcgaagg catgcagatc
1128661 caggtgaccc gcaatcggat caagaaggtc accgagcggc tgccgctgcc gccgaacgcg
1128721 cgtcgtgtcg aggacccgga gatgaacatg agccgggagg tcgtcgaaga cccgggggtt
1128781 ccggggaccc aggatgtgac gttcgcggta gctgaggtca acggcgtcga gaccggccgt
1128841 ttgcccgtcg ccaacgtcgt ggtgaccccg gcccacgaag ccgtggtgcg ggtgggcacc
1128901 aagcccggta ccgaggtgcc cccggtgatc gacggaagca tctgggacgc gatcgccggc
1128961 tgtgaggccg gtggcaactg ggcgatcaac accggcaacg ggtattacgg tggtgtgcag
1129021 tttgaccagg gcacctggga ggccaacggc gggctgcggt atgcaccccg cgctgacctc
1129081 gccacccgcg aagagcagat cgccgttgcc gaggtgaccc gactgcgtca aggttggggc
1129141 gcctggccgg tatgtgctgc acgagcgggt gcgcgctgac catccggctg ctcgggcgca
1129201 ctgagatcag gcggctggcc aaagagctcg actttcggcc gcgcaaatct ctcggacaga
1129261 acttcgtgca cgacgccaac acggtgcgac gggtggttgc cgcctccggg gtcagccgtt
1129321 ccgacctggt tttggaggtc gggccgggcc tgggatcgct gaccctggca ctgctcgacc
1129381 gcggcgcgac cgtcaccgcg gtcgagatcg atccactact ggcttctcgg ctgcaacaga
1129441 ccgtggcgga gcactcgcac agcgaggttc accgactaac ggtggtcaat cgcgacgtcc
1129501 tggccctgcg ccgggaggat ctagccgcgg cgccgaccgc ggtggttgcc aatctgccgt
1129561 acaacgtagc ggtaccggcg ttgttgcatc tgcttgtcga gttcccgtcg atccgtgtcg
1129621 tgacggtgat ggtgcaggcc gaggtcgccg aacggctcgc cgccgagccg ggcagcaaag
1129681 agtacggcgt gcccagcgtt aagctgcgct tcttcgggcg ggttcgccgc tgcggcatgg
1129741 tgtcgccgac cgttttctgg cccattccgc gtgtctattc cgggctggta cgcatcgatc
1129801 gatatgagac ctcgccctgg cccaccgacg acgcttttcg acggcgggta ttcgaactcg
1129861 tggacatcgc attcgcgcag cggcgcaaga cttctcgcaa cgcgtttgtg cagtgggcgg
1129921 gctcgggaag cgagtcggcg aatcgattgt tggcggccag catcgacccc gcccgtcgcg
1129981 gtgagacgct gtccatcgac gacttcgtgc ggctgctgcg acggtccggc ggctccgacg
1130041 aggccaccag caccggccgg gacgccaggg cgccggacat ttcggggcac gcgtcggcga
1130101 gctgacgggg cgccgccgcg tgtggtcggc gcgtcacagc gatagtctgc tgcggtgtcc
1130161 gcatctgacg gcaacaccgc tgaattgtgg gtgcccaccg ggtcggtcac cgttcgggtg
1130221 cccggaaagg tcaacctcta tctggcggtc ggcgatcgcc gcgaggacgg ctatcacgag
1130281 ctgaccacgg tatttcatgc cgtctcgctg gtcgacgagg taaccgttcg taacgctgat
1130341 gtgctctcgc tcgagttggt cggcgagggg gccgaccagc tgccgaccga cgaacgcaat
1130401 ctcgcctggc aggcggccga gctgatggcc gaacacgtgg gccgggcgcc ggacgtctcg
1130461 atcatgatcg acaaatccat tccggtcgcc ggcggcatgg ccggtggcag cgcggacgct
1130521 gcggcggtcc tggttgcgat gaactcgttg tgggaactca atgtgccccg ccgcgacctg
1130581 cgcatgctcg ccgcgcggct aggcagcgat gtgccgtttg ccctgcatgg tggtaccgcg
1130641 ctggggacgg gtcgcggcga ggagttggcc accgtgttat cccgcaacac cttccactgg
1130701 gtcctggcgt tcgccgacag cgggttgctc acctccgcgg tgtacaacga gctcgaccgg
1130761 ctcagggagg tgggggatcc gccccggctt ggtgagcccg ggccggttct ggctgcctta
1130821 gctgcgggtg atccggatca gctggcgccg ttgctgggta atgaaatgca agcggccgcg
1130881 gtgagcctgg acccggcgct ggctcgtgcg ttacgcgccg gtgtggaggc cggcgcgctc
1130941 gcaggcatcg tgtccggttc gggtcccacg tgtgccttcc tgtgcacctc ggcgagctcg
1131001 gcgatcgatg tcggcgcgca gctgtcgggg gcgggagttt gtcgcaccgt tcgagtcgcc
1131061 accgggccgg tacccggcgc ccgcgtggtg tctgcgccga ccgaagtgtg accgaattct
1131121 tgggagcatg cctcgggcgg ccaggggtat ccgcgcgtgc cgaggccggt gggtcgatcg
1131181 gctggcgcac cagcatgcca gcggtagggc cgcaggcatc cgccctcgcg aggtcggtgg
1131241 cgcgcatcaa agccaggcgc aaaagccata ccatgatgcg acagagccgc tcggcgagag
1131301 cctccgctac cggccagctc acggcgatag ctgcatcaac ggccatcgag acaacccgtc
1131361 ggcacgggaa tcctcgcagt tcaccgcggg gagtacggca aaggctgtga ccaagctgtg
1131421 acatcgccct caaacctcgg cagagtttgg cagctactta agagttgctt aagataatcc
1131481 gcggtgttgg gtcgtgggct catcaccgaa ccgagaccca accgctcccc aactgtgtgc
1131541 gcgcgcctgt cgcgatgtgg catccggtag gcggaccatg aaaacccgga ccttggggac
1131601 agcaccggaa ccgaggaggt tgccttgagc aggttcaccg agaagatgtt ccacaatgcc
1131661 cgcaccgcga cgacgggcat ggtcacaggt gaaccgcaca tgcccgtccg ccacacctgg
1131721 ggcgaggtcc atgagcgtgc tcgttgcatc gcgggcggcc tggccgccgc gggtgtcggt
1131781 cttggtgacg ttgttggggt gctggccggc ttcccggtgg agatcgcccc cacggcgcag
1131841 gccctgtgga tgcgcggggc cagcctgacc atgctgcacc agcccacacc gcgcaccgac
1131901 ttggccgtgt gggccgagga caccatgacc gtcatcggca tgatcgaggc caaggccgtg
1131961 atcgtctccg agcccttcct cgtggccatt cccatccttg agcagaaagg catgcaggtc
1132021 cttaccgtcg ctgacctttt ggcgtcggat ccgatcggcc ccatcgaggt cggcgaggac
1132081 gacctggcgt tgatgcagct gacgtccgga tctaccggct cccctaaagc cgtccagatc
1132141 acccaccgca acatctactc caacgccgag gcaatgttcg tcggcgccca gtatgacgtc
1132201 gacaaggacg tcatggtcag ctggttgccc tgcttccatg acatgggcat ggtgggcttc
1132261 ttgactatcc cgatgttctt cggtgcggag ctggtcaagg tcacgccaat ggacttcctg
1132321 cgcgacacgc tgctgtgggc gaagctcatc gacaagtacc agggcaccat gaccgcggcg
1132381 cccaacttcg cctacgcgct gctcgccaag cggttgcggc gccaggccaa gcccggcgac
1132441 ttcgatctgt cgaccctacg cttcgcgctg tccggcgccg agcccgtcga acccgccgac
1132501 gtcgaggacc tgctcgacgc gggcaagccg ttcggcctga ggccctcagc gatcctgccg
1132561 gcctacggca tggccgagac cacgctggcg gtgtccttct cggagtgcaa cgccggcctc
1132621 gtcgtggacg aggttgacgc cgacctgctg gcggctctgc gccgggccgt tcccgccacc
1132681 aaaggcaata cccgcaggct ggccacgcta ggtccgctgc tgcaggacct agaggcccgc
1132741 atcatcgacg aacagggcga tgtcatgccc gcccgcggcg tgggtgtcat cgagctgcgc
1132801 ggcgagtcgc taactcccgg ctacctgact atgggtggct tcatcccggc ccaagacgag
1132861 catggctggt acgacacggg cgacctcggc tacctcaccg aggagggcca cgtggtggta
1132921 tgtggccgcg tcaaggatgt catcatcatg gccgggcgca atatttaccc gaccgacatc
1132981 gagcgggcgg ccggccgcgt cgacggcgtt cgtccgggtt gcgcggtggc cgtgcgtctc
1133041 gatgccggac attcgcgcga atcctttgcc gtcgcggtcg agtcgaacgc cttcgaggat
1133101 cccgccgagg ttcgtcgcat cgagcatcaa gtggcccacg aggtggttgc cgaggtcgac
1133161 gtgcggcctc gcaacgtcgt ggttcttgga cccgggacca ttccgaagac gccgtcgggc
1133221 aagctgcgtc gggccaactc cgtcaccctg gtcacctaag gccgccgagc agacgcaaaa
1133281 tcccctcgac acgccggttg cgaggggatt ttgcgtctgc tcacgcgggt cgttaccagg
1133341 cgtggacgcg gttttgtgcg ggctccatgc cctgttcgat aagcagctcg gtggcatcgg
1133401 cggcctgctc gcagatcgtg gggacctcgg cgcgctcggc cggggtaaag ttctccaaca
1133461 caaacgccgc cgggtccttg cggccgggcg ggcggccgat cccgatacgc acccgctgaa
1133521 agtctttggt acccagcgcg gccaccaccg agcgcaaccc gttgtggccg ccttcgccgc
1133581 cgccgatctt gagccggatg cggccgaact cgaggtcaag gtcgtcgtgg atgacgatga
1133641 tgttggccgg cgccaccgag tagaacttcg ccagcggccc tatctggcgg ccggactcgt
1133701 tcatgtagca gcgcggcttg gccaaaacca gggagcgccc ggctgatcta ccagtggcga
1133761 cttcggcgcc ggaacgcttg tgtgccttga acttcgcgcc tagtcgcgcg gcgagcagat
1133821 cggcgaccac gaacccgagg ttgtgccggg tacgggcgta attggctcca gggttgccga
1133881 ggccgaccac gagcaacggc tcggccatgt cgcaagccgt ctactcggac tcgccagcgg
1133941 cctcggcttc gccggcttct accgcggctt cctcggcttc ctcggctcct gcgacttcgc
1134001 cctccagctc ctcggcggtt ggcgccttca ccacgttgac caccaacaga tcagggtcag
1134061 aaatcaggct gacaccggcc ggcagcgcga tctgcccggc ggtgagctgg gtgcctggtt
1134121 cggcaccttc gatggacacg gtcaactgct cgggaatcga cagcgcctcg gcctcgatct
1134181 cgatgctgtt ggtctcttgg gtgaccaggg tgtcgggtcc ggcctggccc tcgacgacca
1134241 cgctgacttc gacgacgacc ttctcgccac ggcgcacgac cagtaggtcg gcatgctgga
1134301 tggtgcggcg gatcggatgg atatgaagtg ccttggtcag tgccagctgt tccttaccgg
1134361 cgatgtcgag ggtcaacacc gcgttggtgc cggaatgccg cagtacggcc gcatagtcgt
1134421 gtccgggcag ctccaggtgc tgtggctcgg cgccgtggcc atacagcaca gcgggtatct
1134481 tgccggcgcg ccgggcccgc cgggacgcgc ccttgccggt ctcggtacgc accgtgacgc
1134541 gcagctggtt gcttgcggat ttggccatat gtcgctcctg ggtggctcgg ttacctcgtt
1134601 tgggggcacg gccagggtcg cgacagcttg tcggcctccg tcgataacgg tgttctgccg
1134661 gcctgctgta gaccgccgac caccctcgcc gtgacgcccg gctaggctaa cccatggcta
1134721 ctgcattggg gaaattcgat ccttgtgagc tgctcggata gctgtgcccc aaccgtgcgg
1134781 acaattactt tgccgcgacg acgaatccgg cgatgatcgc ctcgatgtcg gaagcgtgct
1134841 tgacggcctc gttggccaga ctcgtgatgg tgagctgcac caggtagcgc tgcttggccg
1134901 gcggtgcgcc ggttgggaag acgatccggt tccaggtgtg cagtcgcctg ccgtgcaggt
1134961 cataactgcc ctgaatcatc gaggacggaa acccgttgaa gtctgccgtc gaggagtcca
1135021 attcggtgaa gttcgtcgac agccgggcat cggcagtgcc atgcttgagc gcttcggcga
1135081 tatcgaagtc ccggtgcagc ttgaacacca tgagcatggc cgttggatag ctttcgccct
1135141 tggcgatcat ctccgtgttc ggggtgatgt tcggattttt catcggtgcc cagcccggtg
1135201 gtgtcggaat cgacacggtc aggtcggtca ggctgctcgg tgccaccggc tctccggtga
1135261 cgccgacgct ttccagatac ttccacagcg ggaccggcac ttccgtcgtg gtcgagacgg
1135321 cgctggtggt tgggctcgtg gacaaaatcg actggaagtc aggcgatttc ggtccgcaag
1135381 cgaccgctga cattgccagc gtggctaccg cgaccgcgac cgccaagggt ctcacagaat
1135441 cttgcggaca gcgtcgaccg gccaagcccg ccggatgccc tcaaggatga cggctgccat
1135501 ctatgcgtcc ccgtcgaaaa gtcctgttac tgagccgttt tcgaagaccg cccggattgt
1135561 gctggccagc agcggcgcga tggacaaaac ggtgagctgg gggaagcgct tgtcttcgcc
1135621 gatcgggagc gtgttcgtga cgatcacttc gcgggcgccg caggaggcca gccgctgcgc
1135681 agcggggtcg gagagcacgc cgtgggttgc cgcgatgatc acgtcaccgg cgccgtcgtt
1135741 gtgcagcaat gccaccgcgc cggcgatggt gccgccggtg tcgatcatgt cgtcaatcag
1135801 gacacaggtg cgcccggcca cgtcgccgac gacgcggttg gacaccactt ggttgggtac
1135861 ccgcggatca cgggtcttgt ggatgaaggc gaggggaaca ccacctaatg cgtcggccca
1135921 cttctcggcg atgcgtaccc ggccggagtc aggggagacg accaccatgt tgccgtccgg
1135981 gtagttgtct ctgatgtaac cggtcagcag gttctgaccg cgcatatgat cgaccggccc
1136041 gtcgaagaaa ccctggatct ggtcggtgtg caggtcgacc gtcacgatcc ggtcggcgcc
1136101 cgcggtcttg agcaggtcgg cgatcagtcg cgcggagatc ggttcgcggc cacggtgttt
1136161 cttgtcttgc cgggcatacg gatagaacgg catgacggcg gtgatccgtt tggcgctgcc
1136221 ccgtttgagc gcgtcgatca tgatcagctg ttccatcagc cacctgttca ccggtgccgg
1136281 gcaggattgc aggacgaagg cgtcgcaacc gcgtaccgat tcgtggaagc gcacgaagat
1136341 ctcgccgttg gcgaactccc gcgcgtcctg agaggtgacg tggacgtcga gctctttggc
1136401 tacctgctcg gccagctccg gatgggcgcg gccggcaaag agcatcaggt ttttgcgatt
1136461 atcggtccag tcgtggctca acgcgctgcc ctcgccgttt gggatcgaat tggattaccc
1136521 atggtacgta gcgcaccgcc cggatttgtc gccgggtagc cgggatgcga cttcacggtg
1136581 tctgatcagc gtcgggtggt tgtgtgggct gttggcaggc catttctgag gctctttttg
1136641 aggcctgagc cgctgggctg ccggggcgtt tgcgctgcac ccagttctcg atgttgcgtt
1136701 gcggacccgc cgacactgcc agcgcccccg gcgggacatc ctcccgcacc actgtgccgg
1136761 ccccggtata cgcgccgtcg ccgatggtta ctggggccac gaacatggtg tcggacccgg
1136821 tccgtacgtg cgaaccgacg gtggtgcgcc gtttggacgt accgtcgtag ttgacgaaca
1136881 cgctggaggc gccgatgttg ctgtactcgc cgatgtcggc gtcgccgacg taggtcaggt
1136941 gcggcacctt ggtgccggtg ccgatggtgg agttcttgac ctcgacgaac gcgcccagct
1137001 tgccgtcggc gcccaacgcg gttccgggcc gcaggtaggt gaagggcccg accgcggcgc
1137061 catccccaat cgacgacgac gaaccgtggg tgcgcaccac cgaggcaccg tcgccgacgg
1137121 cgacgtcggt cagggtggtg tcgggaccga cgacacagcg accgccgatc tgggtgcggc
1137181 ccagcaactg ggtacccggg tgaatgacgg tgtcgcggcc gatggtgacg tcgacgtcga
1137241 tccaggtggt agccgggtcg acgacggtga cgccggccag ctggtgagcg gccaccaccc
1137301 gccggttgag ttcggaggcc agctcggcca gctggacgcg attgttgacg ccggccacca
1137361 acgcgctgtc gtcgacgtgg ctggcatgta cggtctggcc gtcggagcgc aagatggcga
1137421 tgacgtcggt gaggtagagc tcctgttggg cgttgttgga gctcagccgg ctcagtgcgg
1137481 accgcagcgc ggcgatgtcg aaggcgtaga cgccggcgtt gacttcgcgg atttcccgct
1137541 gcgatggtgt cgcgtcggtt tgctccacga tcgccatgac ttcgtgatcc tgggtgcgca
1137601 ggatgcggcc gtagccgaag ggatcatcca gcgtcgtggt cagcaccgtc accgcagccg
1137661 acaccgcgcg gtgggtggcg atcaagtcgg ccagcgtgtc ggcgtccagc agcggggtat
1137721 ctcccgaggt gaccacgacg ttgccggcgt agtcatcggg cagcgcggac agcccgcaga
1137781 gtaccgcatg cccggtccct agcggtcgat cctgcagggc gacgtcgatc gttcggccta
1137841 gggtgtcggc gagttcaccg actagcggcg cgatgcgctg gtgatcgtgt cccagcacca
1137901 cgattagacg ctgcggcgcc agcttggcga tcgcatgcag tacatgcgac agcatgctgc
1137961 gaccggcgag tgtgtgcagc accttggggg tgtccgaacg catccgggtc ccgggcccgg
1138021 ccgctaggac caggaccgcg gtgtcaccag gaaacgtcat caaccctcct tgaagctccg
1138081 tcgccaggac tcgaacctga actatctgaa ccaaaatcag aggtgctgcc gattacacca
1138141 cgacggattg cacatcgatg tgactttaga cggtgtcaac gccgtcagca cagtcaacgc
1138201 tgtcgccgtc tacccaccgg ccccacgcaa accgataccc ttgttgatgt ggccggaccg
1138261 gataaagggc cggataaggc gccggaaaac ccgacgcggg tgacgcgcgc caggatgacg
1138321 gggaccgagc gccgtcacca gctcatcggc atcgcgcgat cgctgtttgc cgaacgcggt
1138381 tacgacggga cgtcgatcga agagatcgcg cagcgcgcca acgtatccaa gccggtcgtc
1138441 tacgaacatt tcggtggcaa ggagggcctg tacgcggtgg tggtcgatcg ggagatgtcg
1138501 gcgctgctgg acggaatcac ctcgtcgctg accaacaacc gatcccgggt gcgggtggag
1138561 cgggtcgcgc tggcgttgct gacctacgtc gaggaacgca ccgacggctt ccgcatcatg
1138621 attcgcgact cgccggcctc gatcagctcg ggcacctatt ccagcctgct caacgacgcc
1138681 gtcagccagg tcagctcgat tctggctgga gacttcgccc ggcgcggcct ggacccggac
1138741 ctggcaccgc tgtatgcgca agcattggtg ggttcggtgt cgatgacggc gcaatggtgg
1138801 ctcgatgcgc gcgaaccgaa gaaggaagtg gtggccgcgc acctggtcaa cctggtctgg
1138861 aatggcctga cccacctgga ggccgatccg cggctacagg acgagtagcg ggcggggaag
1138921 ccgggcccaa tgttgactaa cctcggcgcc ctagaatggc cgcatcatga ccgcaccggg
1138981 gcctgcctgc tcagataccc cgatcgcggg gctcgtcgaa ttggcgctga gcgcgccgac
1139041 attccaacag ctcatgcagc gcgccggggg tcgacccgac gaattgacgc tcatcgcgcc
1139101 ggccagcgcg cggctgttgg tcgccagtgc gctggctcgg caggggccat tgctggtggt
1139161 caccgccacc gggcgggaag ccgacgacct ggccgccgaa ctgcgtggtg tgttcgggga
1139221 tgcggtggcg ttgttgccgt cctgggagac actgccgcac gaacggctct cacccggtgt
1139281 tgacaccgtc ggcactcgcc tgatggcgct gcgccggctg gcccaccccg acgatgccca
1139341 gctgggccca ccgctggggg tagtggtgac ctcggtgcgc tcgctgctgc agcccatgac
1139401 gccgcagctg ggcatgatgg agcccctcac gctgaccgtt ggcgacgaat cccccttcga
1139461 cggcgtggtg gcgcggctgg tcgagctggc atatacccgg gtggatatgg tcggccggcg
1139521 cggcgagttc gctgtgcgcg gcgggattct ggacatcttt gccccgacgg ccgaacatcc
1139581 ggtgcgggtc gagttctggg gcgacgagat caccgagatg cggatgttct cggtagccga
1139641 ccagcgctcg attccggaga tcgacattca cacactggtt gccttcgcct gccgtgaact
1139701 gctgctgagc gaggacgtgc gggcgcgggc cgcccaactg gccgcacggc atcccgcggc
1139761 cgagagcacc gtcaccggca gtgcttccga catgctggcg aagctcgccg agggcatcgc
1139821 ggtcgacggc atggaggcgg tgttgccggt gctctggtcc gacgggcacg cgttgctgac
1139881 cgatcagctg cccgacggca cgccggtgtt ggtgtgcgac ccggaaaagg tgcgcacccg
1139941 cgccgcggat ctgatcagga ctggccgtga attcctggaa gcctcgtggt cggtcgcggc
1140001 gctgggaact gcagaaaatc aagcccccgt cgacgtcgaa caactgggtg ggtcggggtt
1140061 cgtcgaactg gaccaggtgc gggccgcggc ggcccgaacg ggtcatccgt ggtggacgtt
1140121 gagccaattg tccgacgagt cggcgatcga gttggacgtt cgggccgcgc cgtcggcgcg
1140181 cgggcaccag cgtgacatcg acgaaatctt cgcgatgcta cgtgcccaca tcgcgaccgg
1140241 cgggtacgcc gcgctggtcg cgccgggcac cggaaccgca caccgcgtgg tggaacggct
1140301 gtccgagtcc gacacccccg cggggatgct cgatcccggc caggcgccca agccgggagt
1140361 cgtcggggtg ctccagggcc cgctgcgtga cggcgtcatc attcccggcg ccaacctggt
1140421 cgtcatcacc gagaccgatt tgaccggcag ccgggtcagc gccgccgagg gcaagcggct
1140481 ggcggccaag cggcgcaaca tcgtcgaccc gctggcgctg acggccggtg acctggtggt
1140541 gcacgatcag cacggcatcg gccggttcgt ggagatggtc gagcgcacgg tcgggggcgc
1140601 ccgccgggag tatctggtgc tggagtatgc ctcggccaag aggggtggcg gggcgaaaaa
1140661 tactgacaag ctctatgtcc cgatggattc gctggaccag ctgtcgcggt atgtcggcgg
1140721 gcaggcgccg gcgctgagcc ggctgggcgg cagcgactgg gccaacacca agaccaaggc
1140781 gcgccgcgcg gtgcgcgaga tcgcgggcga gctggtctcg ctgtacgcca aacggcaggc
1140841 cagccccggg catgcgttct cgccggacac gccgtggcag gccgagctgg aggacgcgtt
1140901 cggcttcacc gagaccgtgg accagctcac cgccatcgaa gaggtcaagg cggacatgga
1140961 aaagccgatc ccgatggacc gggtgatctg cggcgatgtc ggctacggca agaccgagat
1141021 cgcggtgcgg gcggcgttca aggcggtcca agacggtaaa caggtcgcgg tgctggtgcc
1141081 caccacgctg ctggccgacc agcatctgca gacgttcggc gagcgaatgt ccggattccc
1141141 ggtgaccatc aagggtctgt cgcggttcac cgacgccgcc gagtcccgcg ccgtgatcga
1141201 cggcctggcc gacgggtcgg tggacatcgt gatcggcacc catcggctgc tgcagaccgg
1141261 ggtgcgctgg aaggatctgg gcctggtggt ggtcgacgag gagcagcggt tcggcgtcga
1141321 gcacaaggag cacatcaagt cactgcgcac ccatgtcgac gtgctgacca tgagcgccac
1141381 cccgatcccg cgcacgttgg agatgagcct ggccgggatt cgcgagatgt cgaccatcct
1141441 gacgccgccc gaggagcgct acccggtgct gacctacgtc ggaccgcacg acgacaagca
1141501 gatcgccgcg gcgctgcgcc gggagctgct gcgcgacggg caggcgttct acgtgcacaa
1141561 ccgggtcagc tcgatcgacg cggccgccgc ccgggtgcgt gagctggtgc ccgaggcgcg
1141621 ggtggtggtc gcgcacgggc agatgcccga ggacctgttg gagaccaccg tgcaacggtt
1141681 ctggaaccgc gagcatgaca tcctggtttg caccaccatc gtggagaccg gcctggacat
1141741 ctccaacgcc aacactttga tcgtcgagcg cgccgatacc ttcgggctgt cccagctgca
1141801 ccagctgcgt ggccgggtgg gccgcagccg ggagcgcggc tacgcctatt tcctctatcc
1141861 accgcaggtg ccgctgaccg agaccgctta cgaccggttg gcgacgatcg cgcagaacaa
1141921 tgagctgggc gcgggcatgg ccgtggcgtt gaaggaccta gagatccgcg gtgccggcaa
1141981 cgtgctcggc atcgagcagt ccggacacgt cgccggcgtc ggattcgacc tgtacgtgcg
1142041 gttggtcggc gaggccctgg agacgtaccg ggacgcgtac cgggcggccg ccgacggcca
1142101 aaccgtgagg accgccgaag aacccaagga tgtgcgaatc gacctgcccg ttgacgcgca
1142161 cctgccaccg gactacatcg ccagtgatcg gctgcggctg gagggctacc ggcggctggc
1142221 ggccgcctcc tctgatcgcg aagtggcggc cgttgtggac gagctaaccg atcggtatgg
1142281 ggccctgccg gagccggccc ggcggctggc ggcggtggca cggctgcggc tgctgtgccg
1142341 tggctccggc atcaccgacg tgacggcggc gtcggcagcg accgtgcggc tgtccccgtt
1142401 gacgctgccg gactccgccc aggtgcggct gaagcgaatg tatcccggag cgcactaccg
1142461 tgccacgacg gccaccgtgc aggttcccat tccgcgagcc ggtggcctcg gcgcgccgcg
1142521 aatccgcgac gtcgagctgg ttcagatggt ggccgatttg ataaccgcgc tcgctgggaa
1142581 accgcgccag catattggta taacgaaccc tagcccgcca ggcgaagacg gccgtggtcg
1142641 caacacgacg attaaggagc gacaaccgtg atgattgtcg tcctggtcga cccccggcgt
1142701 ccgacactgg tgcctgttga agcgatcgag ttcctgcgcg gcgaggtgca atacaccgag
1142761 gaaatgccgg tcgcggtgcc ctggtcgcta ccagcggctc gttcggcgca cgccggaaac
1142821 gacgcgccgg tgttgctgtc gtctgacccc aaccatcctg ctgtcattac tcgactggcc
1142881 gccggtgccc ggctgatctc ggcaccggat tctcagcgtg gcgaacgact cgtcgacgcc
1142941 gtcgcgatga tggacaagct gcgcaccgcc ggaccgtggg aaagtgagca gactcacgac
1143001 tcgctgcgca gatacctgct ggaggagacc tacgagctgt tggacgcggt ccgcagcggc
1143061 agtgttgacc agctgcgcga agagcttggt gatctcttgc tgcaggtcct ctttcacgcc
1143121 cggatcgctg aggatgcgtc gcaatcgccg ttcaccatcg acgacgtcgc cgacacactg
1143181 atgcgaaagc tcggcaatcg ggcgccagga gtacttgcgg gcgaatcgat ttcgctcgaa
1143241 gatcaactgg cgcaatggga ggcagccaag gcctcggaaa aggcgcgaaa gtcggtagcc
1143301 gacgatgtcc atacgggcca gccggcatta gcgctggcgc agaaggttat tcagcgtgcc
1143361 caaaaggctg ggctgcccgc tcacctgatc cccgatgaga tcacttctgt ttcggtttca
1143421 gctgacgtag atgcggaaaa cacgctgcgc actgccgttt tggactttat tgacaggctg
1143481 cgctgtgccg agcgggcaat tgccgtcgca cgccggggca gcaacgttgc cgagcagctc
1143541 gatgtgacgc cgctgggtgt gatcaccgag caggagtggc tcgcgcattg gccaactgct
1143601 gtcaacgatt cccgcggcgg gtccaagaaa cgtaaaggca tgcgataacc gccccgagtg
1143661 cgacggggta gtcaacaaac ccatgggacg atgatcgtga cggaagccgg tataggtgcc
1143721 ctacgaggga gagttgtgtc gccgagacgc tggttgcggg cggtcgccgt gataggggcg
1143781 accgcgatgc tgttggcgtc gagctgcact tggcagctga gccttttcat caccgacggc
1143841 gtgccgcctc cgcccggcga tccggtgccg ccggtggata cgcacgccgg cggccggccc
1143901 gcggatcagt tgcgcgaatg ggcggagaaa cgtgctgcgg cattgggaat tccggtcatc
1143961 gcgctggagg cctacgccta cgccgctcgc gtcgccgagg tcgagaatcc caagtgtcat
1144021 cttgcgtgga ccacgctggc gggcatcggg cgggtggaga gtcaccacgg aacctaccgg
1144081 ggcgccacga ttgcgcccaa tggggatgta agccccccga ttcggggcgt ccgcctcgac
1144141 ggcaccggcg gcaccctgcg catcgtggac agggacgggg gcggcctgga cggtgacgcc
1144201 gcggtggagc gtgcgatggg gccaatgcag ttcatttcgg aaacctggcg gttgtacggg
1144261 gtcgctgcca gaaacgacgg catcgccaac gtcgacaaca tcgatgatgc tgccctctcg
1144321 gcagcgggct atttatgctg gcgtggaaag gatctcgcga caccgcgagg gtggataacc
1144381 gcgctgaggg cctacaacaa ctccgttatc tatgcgcggg cggtccggga ctgggcgacc
1144441 gcgtatgcgg cgggtcatcc gctgtagcag gatgaaccgc taacccaggc tttacgctaa
1144501 cagcggtcgg ggccagccaa cccaagaccg tccgtgcagc agctacgacg caaggagaac
1144561 ccagtgccga ttatcgagca ggttagggcc cgagagatcc tcgattcccg cggcaacccg
1144621 acggtggagg tcgaggtggc gcttatcgac gggacattcg cccgggccgc ggtgccgtcg
1144681 ggcgcctcga ccggggagca cgaggccgtc gagttgcgcg acggcggcga tcgctacggc
1144741 ggcaaaggcg tgcaaaaagc cgtgcaggct gttcttgatg agatcggccc ggccgtcatc
1144801 ggactcaacg ccgacgacca gcgattggtc gaccaggcgc tggtggacct agacggcacc
1144861 cccgacaagt cccggctggg cggcaacgcg atcttgggtg tctcgctcgc tgttgccaag
1144921 gcggcggcgg attcggcgga gctgccgttg ttccgttatg tcggggggcc aaacgcgcac
1144981 attctgccgg taccgatgat gaacatcctc aacggcggcg cacacgccga taccgctgtc
1145041 gacattcaag agttcatggt ggcgccaatt ggcgcgccca gcttcgtcga ggcgttgcgc
1145101 tggggcgctg aggtgtacca cgcgctcaag tcggtcctga aaaaggaggg gctgtccacc
1145161 ggcctgggcg acgaaggcgg cttcgccccg gatgtggccg gcaccaccgc ggcgttggac
1145221 ctgatcagcc gggccatcga gtcggcgggc ttgcgacccg gcgccgacgt ggcgctggcc
1145281 ctggacgcgg cggccaccga gttcttcacc gacggcaccg gctacgtctt cgagggcacc
1145341 acccgtaccg cagaccagat gaccgagttc tacgcgggcc tgctcggcgc ctacccgctg
1145401 gtgtcgatcg aagacccact gtccgaagac gattgggacg gctgggccgc gctgacggcc
1145461 tcgatcggtg accgggtgca aatcgtcggc gacgacatct ttgtcaccaa tcccgagcgg
1145521 ctcgaggagg gcatcgaacg gggcgtggca aatgcgttgc tggtcaaggt gaaccagatc
1145581 gggacgttga ccgagacact cgacgcggtc acgctggctc accacggcgg ataccgcacg
1145641 atgatcagtc accgcagtgg cgagacggag gacaccatga tcgccgacct cgcggtggcc
1145701 atcggcagcg ggcagatcaa gacgggcgcg cctgctcgca gtgagcgcgt cgcaaaatac
1145761 aaccagctgc tgcggatcga agaggcgctt ggcgacgcgg cccgctacgc gggcgacctg
1145821 gcatttcctc ggttcgcgtg cgagacgaaa taggtacatg cccgaagcga aacggcccga
1145881 atcgaagcgc cggtcgccgg catcgcgccc ggggaaggcc ggcgactcgg ttcggggcgg
1145941 tcgcgccacc aagccttccg caaaaccctc cacgcccgca ccgcacgcca gccgcaagac
1146001 cactcgcacg ccgcatgagc acattgtcga acccatcaaa cgggcgatca ccgaatcggt
1146061 cgagaagcgc tccgaacagc ggctggggtt caccgcgcgg cgcgcagcga tcctcgccgc
1146121 ggttgtatgc gtgctgacgc tgaccattgc gaggccggta cgcacctact tcgcgcagcg
1146181 cgccgagatg gaacaactgg ctgcgaccga ggccatgttg cgccgccaga tcgctgacct
1146241 ggaggaacag caggttaagc tcgccgatcc ggcgtatatt gcggctcagg cccgcgaacg
1146301 gctcggcttt gtgatgcctg gagacatccc gtttcaggtc cagcttccgt cgacgccgtt
1146361 ggcgccgccg caaccggggt cagacgcggc tactgcgacc aacaacgaac cctggtacac
1146421 cgcgctgtgg cacacgatcg ccgacgaccc gcacctgccg cctgccgcgc caccggcacc
1146481 ggagcccgga cgtccgggcc cgctgccgcc ggcctcgcca aaccccgagc agcccggtgg
1146541 ttgatcgtgc cgatctggag gtggtcacgc ggcaactcgg ccgtgcaccc cggggtgtgc
1146601 tcgcgatcgc ctatcgttgc cccaacggtg aacccggcgt cgtgaaaact gcgccgagac
1146661 tgcccgacgg cacgccgttt ccgaccctgt actacctgac gcatccggtg ctcacggcgg
1146721 cggccagcag gttggagacc acgggactca tgcgcgagat gaaccggcgg ctgggccagg
1146781 atgcggagtt ggccgccgcc tatcgacggg cacacgagtc gtatctgtcc gagcgtgacg
1146841 ctctcgagcc gctcgggaca acggtctccg cggggggcat gcccgaccgg gtcaagtgcc
1146901 tgcatgtgct gatcgcgcat tcgctggcca agggcccggg gttgaaccca ttcggtgacg
1146961 aggcgctggc gttactggcc gccgagccac ggacggccgc gaccctggtg gctgggcagt
1147021 ggcgctaacc cgggtcgccg cgatcgactg cggtaccaac tcgattcgct tgctgatcgc
1147081 cgacgtggga gccgggttgg cgcgcggaga gctgcacgat gtgcatcgtg agacccggat
1147141 agtgcgcctg ggccagggag tcgacgccac cggtcggttc gcgccggagg cgattgcgcg
1147201 gacccggacc gccctgaccg actacgccga actgctgacg tttcaccatg ccgagcgggt
1147261 gcggatggtc gccacgtcgg ccgcccgcga tgtggtcaat cgcgacgttt tctttgcgat
1147321 gacggccgac gtgttgggcg ccgcgctgcc cggctcggcc gcggaggtga ttaccggcgc
1147381 cgaggaggcc gagctctcct tccgtggagc ggtgggcgaa ttaggcagcg ccggtgcgcc
1147441 tttcgtcgtc gtggacctcg gtggcggttc caccgagatc gtgctgggcg agcacgaagt
1147501 ggttgccagc tactcggcgg acatcggatg cgtccggctg accgaacgct gtttgcactc
1147561 cgacccgccg acgttgcagg aggtgtccac ggcccgccgg ctggttcgcg agcggctcga
1147621 gcccgcactg cgcaccgtgc cgctggagct ggcccggacc tgggtcgggc tggctggaac
1147681 gatgaccaca ctgtccgcgc tggcgcagtc catgacggcg tatgacgctg cggccattca
1147741 tctttcgcgg gtgcccggtg ctgatctgct cgaggtttgc cagcggctga tcggcatgac
1147801 tcgcaagcag cgggccgcgc tggcgccgat gcacccgggc cgggccgacg tgatcggcgg
1147861 tggcgcgatc gtggtcgaag agttggcgcg cgagctgcgc gagcgggccg gcatcgacca
1147921 gctgaccgtc agcgaacacg acatcttgga cggcatcgcg ttgtcactgg ccggataagt
1147981 cacatctgcc acacgcgtat ctgcgcgggg ggacactctt ctgcccgcct cgtagcgaca
1148041 accttggccg atgtcagacc cgcatgggaa tgttcggcca tgaccagaca actgcatgga
1148101 attgagcttc gatacgtgct caccctgcac ctggccgtcc atggaccggc ggccattacc
1148161 gaaatgatct aaggcctggg ctggcacggc tttggagtcc ggggcagggc atccaaggtg
1148221 gtgtcggagg cactgcgctg ggaaatcgga cggggccgag tataccggct cgggcgcgga
1148281 cgctacgggc cggggtacat cccgcgctcc accgaatacc ggattcacca acgcgtgttg
1148341 gcgttgcggg catccgccaa cgtgtcgctg cgaggcgggc aaagtgtaca tccgctccca
1148401 gcggaaacgc ctgtggcaga tgtgatttag gcttcgaagc ggtagcccat ccctgattcg
1148461 gtcagcagat gtttggggtg cgacgggtca tcctccaatt tgcgccgcag ctgcgccaga
1148521 tacacccgca ggtaatgggt ttcagtcgca tatgccggtc cccacacttc tttgagaagc
1148581 tccccgcggc cgaccaactt gccgcggttg cgggccagca tttccagcat gccccactcg
1148641 gtcggcgtga gatgcacttc ggcaccgtct ttgatgacct tcttgccggc cagatcgacg
1148701 gtgaatgaat cggtttcgat caccggctgc tccaactcgg cggccgcggt gttacgccgt
1148761 accgctgcgc gcagccgagc cagaaactcg tccattccaa acggtttcgt cacgtaatcg
1148821 tcggcgcccg catcgagggc ctggaccttg tccgacgaat cggtacgcgc cgacaacacg
1148881 atcaccggtg ccgtcaacca gccacgcagc ccgccgagca cgtcgatacc cgacatgtcc
1148941 ggcaggccga ggtcgaggat caccacatcg ggcggatgct cagcggcggc gcgcagcgca
1149001 cccgcacccg tcgaggcggt gatgacctgg tagccacgca cggtcaggtt gatacgcagc
1149061 gcgcgcagga tctggggttc gtcgtcaatc accaagacga gggtcatggg cggtcctcgg
1149121 gagccgccag atcgatcacc actgtgagcc cgccgcccgg ggtatcggta gccgaaatcg
1149181 tgccgcccat agcctcgacg aagccgcgtg ccaccgacat ccccagaccg acaccggtgg
1149241 tgttgtcgtg atcccccggc cgctggaacg gggcaaagag ttgctcctcg gtcccgcgcg
1149301 ggacccctgg gccctcgtcg atgacattaa tcaggacccg ctcacgcacc cgtcccgcgt
1149361 tgacccggac cacgcagtcg ggcgcatatc gcagcgcgtt gtcgatcagg ttggctagca
1149421 cccgctccag caacccggcg tcggccatcg ccacggcgtc tcccacgtcg accttgaccc
1149481 ggtcgatgcc ggatcggtaa aaaccggtgg cgcccttgcc gatgctgacc aaggcccgtt
1149541 gcaccgcttc ctccaggtat gcccggcgca gctgggggcg aatcacgccg gcagccaacc
1149601 gcgacgaatc gagcaggttt gcgaccaggg cggtgagttg gtcgatggac tcctcgatgg
1149661 tggccaacag ctcggcggta tcctcggggg agaaagcgac gtcttcggtg cgcaagctgg
1149721 acaccgcaac cttggccgcc gccagcgggg tgcgcaggtc gtggctgacc gccgacagca
1149781 gcgaccggcg cagctcatcg gccctagcga tggcctcggc ctggccggcc tcttccgcca
1149841 gctcgcgctg cttcaccaga cccgcggcct gtgtcgcgac cgcggtcagc actcggcggt
1149901 cgcgggcggc caacttgcgg cctgccatca gcatccaaaa ctcgtcgtcg ccgacttcga
1149961 ttgcggtgtc ggcggagtcg acgtcccgac acgggtttgt cccgacgcac gcgacggttt
1150021 cgcctgtcga tgcgccctgc cggacacgca gcatggtcac ggcccgttgg gaatacgttt
1150081 cgcggacccg ctgcagcagc gtggcaaggt ctgcgccgcg caacaccgaa ccggcaaaca
1150141 gggccagcaa ctcagcctcc tgggatgcgc gccgagcctc acgggttcgg ctagccgcgc
1150201 cgtccaccaa caccgccacc gcaacggcca tcgccaacaa cacgaattcg gttactgcgg
1150261 cgtccggttc ggcgatggtc caggtgtagc ggggctcggt cagaaagtag ttcagcagca
1150321 tgcccgacag caaggccgac aatgcggcgg gggcgacgcc gcccagcaac gccacgatca
1150381 gcacgccgat gaagaacaac gcgctctcgc cgccgatgcc catgaatcgg tcgagccagg
1150441 ccaccgtgat ggcgcagatc accgagggca ccaccagcgc ggccagccac gacgcgatat
1150501 gccgctcgcg cggggagacc cgcgaccacc cggaggcccg gctggccgcg ggatgggtga
1150561 ccatgtgaac gtcgatgccg ccgggctcct ggacggtgcg ggcgccgatc ccctcgtcaa
1150621 acaggcgtgc ccatcgcgat cgccgcgatg tgccgacgac gagctgcgtg gcgttcatct
1150681 cgcgggcgaa gtccagcagc gcggtgggca cgtcgtcgcc gaccacggtg tgcatggtcg
1150741 caccgaggct tgtcgccagc tcgcggaccc tgcccagctg cggcgcggac acccccgcca
1150801 ggccgtcgcc acggataacg tgaaccacca tcagctcggc gctggacttc gacgcgatcc
1150861 gcgatgcccg tcgcaccaac gtctccgact ccgggccgcc ggtcacggcg acgacgacgc
1150921 gttcccgcgc ctcccacgtg gcggtgatct ttttgtctgc gcggtacttc tccagggccg
1150981 catcaacttg gtcggccagc cacagcaacg cgatctcgcg cagcgcggtc agattgcccg
1151041 tgcggaagta gttcgacagc gcggcatcga cccgttcggc tgcatagacg ttgccgtgag
1151101 caagcctgcg ccgcaacgct tccggtgtga tgtcgaccag ctcgacctga tcggccgcgc
1151161 ggacgatctc gtcggggatc ttctccttct gctcgatgcc ggtgatttgc tccacgacat
1151221 cgtttaggcc ctccaagtgc tggatgttga ccgtcgagat caccgtgatg ccggcgtcga
1151281 ggatttcctg aacgtcctgc cagcgcttgg ggttcttgct gccaggtgtg ttggtgtggg
1151341 cgagttcgtc caccagcacc acctgaggat gacgtcgcag tactgcctcc acatcgagtt
1151401 cgggaaacct ggcaccccga tattcgacgt agcgcggcgg gatcatctcg atgccctcga
1151461 gcagtttcgc ggtcttgttg cgtccgtgtg tctcgacgac cgcggcgacc acgtcggtgc
1151521 cgcgctccag cctgcggtgc gcctcgccga gcatggcgta ggttttgccc acgccggggg
1151581 ccgcgcccag atagatccgc agctgcccgc gcttggtggt cacatgctca atcatccacc
1151641 ggtagggcgt aaagatcgcg caaagatcgg cgaagagcaa cgtcacggtc gtgttcctgg
1151701 ggggcccggc aactaccatc ctgctgggct atctgatgcg ctgcgatgcc ggtgcacaag
1151761 aatcgagagg actcacatgg ccgacttggt gttggtgctg accgtgatgg cctttgccgg
1151821 gctttgcctg ctctacgtcc gtggctgtga acggatcatt cgccgcgacg aaatcgggga
1151881 aacaacagtc gaactcacgc gagcgccggc cgaatggcga tgactacggt cgacaacatc
1151941 gtcgggttgg tgatcgcggt ggcgctaatg gcgttcctat tcgcggcgct gctgtttccg
1152001 gagaagttct gatgtccggg acgagttggt tgcagttcgc ggcgttgatc gcggtgctgt
1152061 tgctcaccgc gccagcgctg ggcggctacc tggccaagat ctacggcgac gaggccaaaa
1152121 agcccggcga tcgggtgttt gggccgatcg agcgcgtgat ctaccaggta tgccgagtcg
1152181 atcccggcag cgagcaacgg tggagcacct atgccctgtc cgtgcttgcg ttcagtgtta
1152241 tgtccttcct gctgctgtat gggatcgcgc ggtttcaggg cgtgctgccg ttcaatccga
1152301 cggacaagcc ggcggtgacc gaccatgtcg ccttcaacgc cgcggtcagc ttcatgacca
1152361 ataccaactg gcagtcctac agcggcgaag ccacgatgag ccacttcacc cagatgaccg
1152421 ggctggccgt gcagaacttc gtctccgcgt ccgccggcat gtgcgtgctg gcggccctga
1152481 tcagaggtct ggcccgcaaa cgggcgagca cgctcggcaa cttctgggta gacctcgccc
1152541 gcaccgtgtt gcgcatcatg tttccgctgt cgttcgtggt ggcgatcctg ttggtcagcc
1152601 agggcgtgat ccagaacctg catggtttca tcgtcgccaa cacgctggag ggcgcccccc
1152661 agctcattcc aggcgggccg gtggccagcc aggtcgcgat caagcagctc ggcaccaacg
1152721 gcggcgggtt cttcaacgtg aactccgcgc atccgttcga aaactacacg ccgataggca
1152781 atttcgtcga aaactgggcg atcctgatca tcccgttcgc gctgtgcttc gccttcggca
1152841 agatggtgca cgaccgtcgt caaggctggg cggtgctggc catcatgggc atcatttgga
1152901 tcggaatgtc agtcgcggca atgtcattcg aggccaaggg caacccgcgg ctggatgcgc
1152961 tgggggtgac acagcagacg acggtcgacc agtccggcgg caacctggag ggcaaggagg
1153021 tgcgctttgg cgtcggtgcg tctgggttat gggcggcgtc gacgaccggc acctccaacg
1153081 gctcggtcaa ctcgatgcac gacagctaca caccactggg cggcatggtc ccgctggcgc
1153141 acatgatgct cggcgaagtc agcccgggcg gcaccggcgt cggattgaac ggcctactgg
1153201 tcatggcgat cctggcggtt ttcatcgccg gcctcatggt aggccggaca ccggagtatc
1153261 tcggcaagaa gatccaggcc accgagatga agctggtgac gctctacatc ctggcgatgc
1153321 ccatcgccct gctgagtttc gccgccgcgt cggtgctgat ctcctccgcg ctggcgtcgc
1153381 ggaacaaccc tgggccgcat ggtctttcgg agattctata cgcctacacg tcgggcgcga
1153441 acaacaacgg gtcggccttt gccggtctga ccgcgtctac ctggtcatat gacaccacga
1153501 tcggagtggc gatgttgatc ggtaggttct tcctgatcat tccggtgctg gcgatcgccg
1153561 gctccctggc acgtaaaggc acgacgccgg ttaccgccgc caccttcccg acgcacaagc
1153621 cgctctttgt tggcctggtc attggggtcg tactgatcgt cggcggcctg acgttcttcc
1153681 ccgccctggc gctggggccg atcgtcgagc agttatcgac ccagtgatga tcgcacgcat
1153741 ggagacctcc gcaaccgccg cggcagcgac gtcggcaccc cggctccggc tggccaagcg
1153801 ctcgctgttc gatccgatga ttgtgcgctc ggcgctgccc cagagcctgc gcaagctggc
1153861 tccgcgggta caggcccgta acccggtcat gttggtcgtg ctggtcggtg ccgtgatcac
1153921 cacactggcg ttcctgcgcg acctcgcatc ctcgacagcc caagagaacg tcttcaacgg
1153981 tctggtcgcc gcgttcctct ggttcaccgt cctgtttgcc aactttgccg aggccatggc
1154041 cgaaggacgc ggcaaggctc aggcggcggc gctgcgcaaa gtccggtccg aaacgatggc
1154101 caaccggcgc acggctgcgg gcaacatcga atcggtccct tcgtcgcggc tggacctcga
1154161 cgacgtggtg gaggtttcgg ctggcgaaac gatcccgtcg gacggcgaga tcatcgaagg
1154221 cattgcctcc gtcgacgagt ctgcgatcac cggcgaatcg gcaccggtga tccgcgagtc
1154281 gggcggcgac cgttccgcgg tgacgggtgg caccgtggtg ctgtcggatc ggatcgtcgt
1154341 gcggatcacc gccaagcagg gacaaacatt catcgaccgg atgatcgcgc tggtggaggg
1154401 cgccgcacgg cagcagacac cgaacgagat cgcgctgaac atcctgctgg ctgggctgac
1154461 gatcatcttt ttgctcgcgg tggtgacgct gcagccgttc gccatctatt ccggcggggg
1154521 acagcgggtg gtcgtgctgg tggcgttgct ggtgtgtctc attccgacca cgatcggtgc
1154581 gctgctgtcc gcgatcggca tcgcggggat ggaccggctg gtgcaacaca acgtgctcgc
1154641 cacatctggg cgggcggtgg aggcggccgg cgacgtgaac acgctgctgc tggacaagac
1154701 cggcaccatc accctcggta accggcaggc caccgagttc gtgccgatca acggtgtgag
1154761 tgccgaggcg gtcgccgacg ccgcccagct gtcgagcttg gccgacgaaa ctccggaggg
1154821 ccgctcgatc gtcgtgctgg cgaaggacga gttcgggctg cgcgcccgcg acgagggcgt
1154881 gatgtcacac gccaggttcg tgccgttcac cgccgaaacc cggatgtccg gggtcgatct
1154941 cgccgaggtt agcggcatcc gtcggatccg caagggtgcc gcggctgcgg tgatgaagtg
1155001 ggttcgcgat cacggtggcc accccaccga ggaggtgggt gccattgtcg acggcatcag
1155061 ctccggcggg gggacacccc tagtcgttgc ggaatggacc gataacagca gcgcgcgggc
1155121 catcggcgtc gtccatctga aggacatcgt caaggtgggc atacgggaac gcttcgacga
1155181 aatgcgccga atgagcatcc gcaccgtgat gatcaccggt gacaacccgg cgaccgccaa
1155241 ggcgattgca caggaggccg gcgtcgacga tttcttggcc gaggccacgc ccgaggacaa
1155301 gcttgcgctc atcaagcgcg aacagcaggg cggtcggctg gtcgccatga cgggtgacgg
1155361 gaccaatgac gcacccgcgc tcgcgcaagc cgatgtcggg gtggcgatga ataccggcac
1155421 ccaggcggcc cgggaagccg gcaacatggt cgatctcgac tccgacccca ccaagctcat
1155481 cgaggtcgtg gagatcggca agcagctgct gatcacgcgg ggcgcgctga cgacgttttc
1155541 gatcgccaac gacgtcgcga agtacttcgc catcatccct gccatgttcg tcggcctgta
1155601 tccggtgctc gacaagctga acgtcatggc gctgcactca ccaaggtcgg cgattctgtc
1155661 ggcggtcatc ttcaatgcgc tggtgatcgt cgccttgatc ccattggcgt tgcggggcgt
1155721 gcggtttagg gcggaaagcg cgtcggcgat gctgcggcgc aacctgctga tctatgggct
1155781 gggcggtctc gtcgtcccgt ttatcggcat taaactggtc gatctcgtca tcgtcgccct
1155841 cggggtgtcc tgatgcgtcg tcaattactg cccgcgctca ccatgctgtt ggtgttcacc
1155901 gtcatcaccg gcatcgtcta cccgcttgcc gtgaccggcg tcgggcaact gttcttcggt
1155961 gaccaggcga acggcgcgct gctcgagcgg gacgggcagg tcatcggctc cgcccacatc
1156021 ggccagcagt tcaccgccgc gaagtacttc cacccgcgcc cctcgtcggc aggcgacggt
1156081 tacgacgctg cggcgagctc gggctccaac ctgggaccga cgaacgagaa gctgctggcg
1156141 gccgtcgctg aacgggtcac cgcctaccgc aaggaaaaca atctgccggc cgatacgctg
1156201 gttccggtcg acgcggttac cggctcgggt tccgggctgg acccggccat atcggtggtc
1156261 aatgccaagc tgcaggcacc gcgggtggcg caggcgcgca atatctcgat aaggcaggtc
1156321 gagcgtctga tcgaggacca caccgacgcg cgtggtctcg gcttcctggg cgagcgcgcg
1156381 gtgaacgtgc tcaggctgaa cctcgcattg gatcgcctct gactctcagg cggtagtggc
1156441 gatctgctgc tcgatcatcg ggagccgcac ccgaaacacc gtctggccgt tgcccgactc
1156501 ggccgtgacc gagccgcgat gcgccttgac gatcgagctg acgatggcca ggcccaagcc
1156561 gtggccggac ccattggacc gagacttgct ggcccgcacg aaccggtcga agaggtgggg
1156621 caggatctcc gggtcgatgt cggggccgtc gtcggtcacc gacaattcaa cacacggcgc
1156681 gttgggacca gtgcggtggc aggtgatccc gatggtcact gtgacgccgg gctgggtatg
1156741 cacccaggca ttggtgagta gattgctgac gagttgatgc aagcgggcat gatccccgtt
1156801 gacccagacc ggctcgtcgg gcagattctt cacccaacgg tgggtgggcg ccgcaaccgc
1156861 cgcgtcattc accgcgttga tgaccaggtc ggtcaggtcg aggtcctcgg tttctagatc
1156921 ttcgccctcg ctgagacggg agagcagcag cagctcgtcg accagcagcg tcatccgccg
1156981 cgcctcggat tcgatgcggg ccagcgcgta ttcggtggtg ggcggtaggt ccgagctatc
1157041 ctgacgtgtc agttcggcat agccctggat cgccgccagg ggagtacgca gctcgtggct
1157101 ggcgtcggtg atgaactgcc gcatccgcag atcggaatcg acgcgatgcg ccagcgcacc
1157161 atcgacgttg tccaacaagc gattcagcgt gtgcccgacg attccgacct cgttatccgg
1157221 gtcggtatcc cccggacgga ctcgcacgct gatctggtgg tcgtcatcgg taagtggcat
1157281 ggtggcgacc tcggcggcgg tcgcggcgac ccggcgcagc gggcgtagcg catatcccac
1157341 cacccacacc gtcagtgctg cggtaaccac cagtgcggcc ccaacaagcg cgacggtggt
1157401 gactttcttg cgggcgatga tctggttggc caggcttagc gatacgccga cgaacagtcg
1157461 atcggcgcca gcggcgctgc tgtcaacctg gtaggcgccc aggctgccca ggctttcgac
1157521 acgcggcggg ccgccgtccc acacttgcgc ttcgatcgcg cggatgacgt cgggcggagc
1157581 gggtcgtgct ccgtcttcgg agaaaacggc cgatccgatc accacgccgt cgtgcagcac
1157641 ggcaatgagg tttccgggcg tctggccggt gaactccagc accgcttgtg acatcgggag
1157701 gttgccggtg ggcgtggatg tttgcgcact gtcgcggtat ctggtgtaag agtggttcaa
1157761 cgcgtgcagg gattcgacta gctcggcgtc gttcatcgcg gtgacatagc cgcttaggct
1157821 cagcacggag acgacaccga cggccaccag cacaacggta acgaccgcca acacgccgag
1157881 cagcaattgc tggcgtaacg agcggggtcg ccagcagggg gcttttctgg accgagtgtt
1157941 tcggtccggg atcatgccag gctcattccg gcggacgcag catgtatcca atgccgcgga
1158001 ccgtatggat cattggctcc cggtcggagt cgatcttctt cctcagatag gagatataca
1158061 ggtcgacaat gctggtgcgg cctgcgaagt cgtagttcca aacccgatcc aggatctcgg
1158121 tacggctcag tgctcgtcgg ggattgcgca tcaggaatcg aagcagttcg aactcggtcg
1158181 aggagagcga gatcggcgta ccgtcgcggg ttacctcccg gctggccccg tcgagcgtaa
1158241 ggtctccgac ccggagtgcc tcatcggcgg gcctttccag atggctggag cggcgcagca
1158301 acccgcgcaa ccgggcgacc agctcctcga ggctgaacgg ctttgtcatg tagtcgtcgg
1158361 cgcccgaggt cagaccggtg acccggtcca tcacggaatc gcgcgcggtg aggaacagcg
1158421 tgggtgtgta gacgtcggat tctcggaccc gtcgcaggat ttccaacccg tccacatcgg
1158481 gaagcatgat gtcgaggacc agcacatcgg ggccgacctt gtcgaacttg gctatggcct
1158541 cttgcccgtc gtgggcgact tcgacatccc agccttcgta gtgcagcgcc atcttgacca
1158601 gattggtcag cgctggttcg tcatcgacca acaacacccg gatcggtgat ccatccgcgc
1158661 gatgaatccg tggcagctgc cccaggatgg cttgccgcgg acgttgactg cgcgtgtacc
1158721 ccgacatcgt cgtcatgctc ccgtatcctc tcaagtcctg tgcaagcgca catgcagttg
1158781 tcacgggatt cataaatttt tcaaatgtcg cttatgtagt tacttcggcc tgaaaaggtg
1158841 accgggcggg atgtcgggct tcggcggtga gaaagcggat ctcggtttcc gggtatacgg
1158901 agcccccggt ggaccggtta tgcggggagg gcgctgatcg tgaccaggtt gtgggcgaac
1158961 acgccgtgtc cgacccaggt ccgggtgcct tcgagaccgc cgatccggcc gcggtcccag
1159021 ccgtagccgc gtttgaggtg gctgatccgg ccttcgcatc cggtccgcca tttgatggtg
1159081 cggcggaacg cttttcggtg ttcttcggcg cgtcgatcct gcgaaggttt gcctttgcgc
1159141 gggatcagca cattcttgac gcccacctcg gtgagctgct ggtcgacggc ggcttcgcca
1159201 tagccgcggt cggcggtgac ggtgcgcggc gtgcgtccgg cgcgcttttt cacccacgcc
1159261 accgctggcg ccagctgcgg cgcatcgggt gggttgccct gctgcacagt gtgatccagc
1159321 acaatcccgt catcgttgtc gacgacctgg gccttgtgct caaactcgac cggcttaccg
1159381 agccgaccct tggtgatcgg ggcgggcatc accgtcgtgc aggctgaccc gtcgactcgc
1159441 cccgtccgaa gtgatgcccg cgacccgctg gcgggtctgc gccacaatct gacgcgtcgc
1159501 gttgagcagc tcggttaggt cgttgaccgc gcgcaccagc ccaccacagc ggcgacccgc
1159561 gaccgcatca cgctcaccgc gggcggccag cgcggcggcc ttggccttgg cccggagcac
1159621 cgcctgcttg gcgttgtcca gcagctgctg ggcctcctga gcagcggctt gggccagctc
1159681 ggccagctcg ccggtgaacc tcagtaccgc ggcccgcgct tcgtcacgcc ccagctccgc
1159741 acgcgagcgc agtttcgctg cgaccgcgtg cgcgcgccga ccggccgcgc gggagcggtc
1159801 gccaacccgg gtgcgcaccg cgccgccagc ggcctgaatc cgtttgccgg ttgcggcgat
1159861 ccggcgcatt gccttggcca acagacccaa gtcggtcgga taagacacgt tcgcccgcgc
1159921 caccgtggta tcggcccgga tccgattggt gcccagcagc ttggcctcgg ccgccttggc
1159981 caacaatgcc tcgttgagcc cgtcgatcgc cgccgatccg caacgcgtgg tgagcttcat
1160041 caatgtggtc ggatgcggca ccgacccgtc cagcgcaatg cggcaaaacc gccgtcaggt
1160101 gatcgaatca gccacctccc ggcacagcga ctcatagccc agccggtagc ggaacttcac
1160161 aaacatcaac tgcagataga cctccatcgg cgtcgacggc cggcccctgc gcgggtcgaa
1160221 gaacggcacg aacggggcga agaacgccgg atcgtccaac aatgcgtcca cccgggccag
1160281 ttcctcgggc agtcggcgca cctcgtcggg cagcagcgac tcccacaacc agcactgatc
1160341 gcctaaagta cgaaacacga tggcctcaat cccttccgca acaagggcat tgaggccatc
1160401 ttcccagttc agcaccatcc gaccggggat caacgcgccg actttagcag gtcgaagtag
1160461 ttagtcgttc agataacaac gtggccacac accaaccggt gtgcggccac gttgtaattg
1160521 acggcgcggg ccttaagcca gctttaggcc cagctggagc cgacggcgct gtcggtttgt
1160581 gccatgttgt tgccggcagc ctgcaccttc tgcccgtggg cgttggcctg ctcgtagatc
1160641 acctggaagt tacggcccag ctgggtaatg aacccctggc aggccgccga accggcgccg
1160701 ccccaaaagt cactcgcggt caacacatca gaaatgatgg cctgatgctc ggcctccagc
1160761 gacccggcct gagcgcggat catggcgccg tgagcgtcga cgtccccgaa ttgatagttg
1160821 atggtcatgt gtcctcctga gtcgtcgggc cgggtcagct gctgaggatc tgctgggagg
1160881 cctgctcttg ctgttcgtag ttgttggcgt cgcgaaccag cccgtcacgc accccgtgca
1160941 gcatgttcac gatgttgcga aacgcctgat tcatctgggt catggtgtct agcgaggtcg
1161001 cctcggccat gccactccag cccgcgcccg agatgttttg cgcggacgcc cacatccggc
1161061 gagcctcgtc ctccaccgtc tgggcgtgca cctcaaaacg gcccgccatg tcccgcatcg
1161121 cgtgcggatc cgtcataaaa cgcgaggcca tgctgctgtc tccttgtctc gaagtcgtca
1161181 cgttgttgaa gttctagcgg ctgtgatcgg cgcggtggtg gccgcgtggc ggacaggtta
1161241 tgactcaacg gttaattgct ggcctcaaac gagtgagatg tccccctttg tccgcatcac
1161301 acgacgacct gtttgggcat gacagtgggc ttgaatccgt accgcggccc ggcataggca
1161361 ccggtgccct tggcggccga ggccattccc ggcatcatcc cggtaactgg gccggcttct
1161421 tcggcggcga cggtccagcc gctgccttcg agcgctgtgg cgccggcggt tgtcgccggt
1161481 gcggccgtag accaggccgc cggcactgac agccggccga ccagggtggc ctcgcctaaa
1161541 cttgcgccga gccccgctgg cgtcaccgag tccgccaacc ccgcggcggc cgcactggcg
1161601 gcaccctcgg cagcctcgat ggcgccttcg gcgatcgcta ccggcgcccc actgttcagg
1161661 gcatttgcta ggaatatcgc ggtggggatg gcggcgttga cataccaagc ggcggtgttg
1161721 actgcgctgt tgatgatgtt tgccacgaac ggggtcgcga gcagggcgtc gatgtcggca
1161781 atgattccgc tcagccccgt cgagtcgaga accgatgtga ctggggaggc gagcccactc
1161841 accgcgttgg gcaggctact gatcaggtcc gctacgctca cctggttgac ggcggcggtg
1161901 gcggcagccg agccgaccgc ggcggactgg gcggccagcc cgcccgggtt ggtggtctgc
1161961 gacggcgggc ttaacggttg cagcatcccg gcggctcccg aagcggccgc gtagccgtac
1162021 atagccagag cgtcctgagc ccacatctcg gcatagaggg cttcggtcgc catgattgcc
1162081 ggtgtgttga tccccaggac gttcgtcgcg accagggccg ccagcagcgc ccggttggcc
1162141 gcgaccacct ccggcggcac tgtcatcgca taggccgcct cgtaggcggc cgccgacgcc
1162201 atggcctgcg agccggcatg cgcagcggct tcggcggtgt aggtcaacca agccagatag
1162261 ggctgggctg cggcgaccat cgccatcgag gccggaccca tccacgactc ggtggtcagc
1162321 cgggtgatca ccgactcata cgacgcggcc gtcgtaccca actcggcggc caggccgttc
1162381 catgcggccc cggcggccat catcggtcct gcacccgcgc cggcgtacat gcgtgcggag
1162441 ttgatctcag ggggtaaagc tccgaaatcc atggggtatt ccgtttccgt ggagttattt
1162501 ggctgaattt cgttgttggt tgagcgtggc cgcccgtacg tctgccgcct agacggttgc
1162561 tggcttgggc atgacgatgg gtttgacgcc gtagcgcggt gcaccgaagc cggcgctgtt
1162621 gcgtgcggcc gaggccaccc ctggcatccc ggggatgaac gtccccgcgg cggcctgcgg
1162681 cgcggcggcg gtccagcccg cgcccggcag tgtgctggtg gtggatacca gggtcgcctg
1162741 tccggcccag gcgggcggca ccgacaacat gccgatcgcg gatgcgctgc ccaggccggc
1162801 cgcaattccg gcctcgccga gggcggcttc ggccgcgccc aatgcaccca attcgcccaa
1162861 ggcggcttcc ccaccgagag ccgaggcggc ctcggccgcc tcctctgcag gcaggaggcc
1162921 gccgccggca aggccgatca gcgtagacgt ggcggaggcc cagttcccgg ccccgatgtt
1162981 gaggatgttg ccaatgccac ccgagagttc gggcgggaac aaccccgtcg tcgcttggat
1163041 gatggccgac gcttcccctg tgatccccga gagtggcgag gcggcagccg atgagttgag
1163101 cgactcggtg acgccgtagg taccggcgct gattcccaga gtgttgacaa acatgtcatg
1163161 catagcctga gcttcggcgc tgacctgctg gtagaaggtg ccgtacgcag tgaagagcgc
1163221 cgcctgcagc gccgaaacct catcgagggc cgccggagcg atggctgtgg tgggcgccgc
1163281 ggcggcagcg ttttgggctg ccatcgcagc accgatggtc ccgagttgcg cggccgcagc
1163341 cgtcaactct tcaggcactg tcttgaggaa tgacatccat tgctccttgt gtgtgaaacc
1163401 tgccggccgc tagcaccccg ggccgaccct gtgtgtttgc gtacggctgc ctgtggattg
1163461 gcgtaacgct aaccggccaa gcctccacag tcgcgaccga aaggcatggg acgcccgacg
1163521 tttacggttt tttaacgttt acgtcagcat ccttaacaag gtcttggcgg ctgacatggc
1163581 ggtgtgatct ggtgcccggg ctagcacact tcggcacaca aatgagacgc gcggcgcgcg
1163641 gattctaggc gaatgacggc tctttcgcac ctggcgtgtc gcggtagggt tggtgcactg
1163701 gatcgggtcc aagcgctaca ttcgccgtca agcctccaca gcccgattgg cagaggcagc
1163761 ggacaatccg cgctcacggg tgctggcgtt tgctagtgcc ggtaatcttc gaaagagtcg
1163821 cttctaactg ccaatatgcc gggtcgaagc cactgtccag cactgtcggc atccagatgg
1163881 gggcgttggc gcgctgatcg atacgccgtc tgcgcggctc ccggcacaat gagttcgtgc
1163941 ccgattcctg gccggtcgtt tgcgttgacg actggtctgt tgccggcctg gagacccagg
1164001 ggcaacaccc gcacgattgg ctcaaacatt cttcgcagaa gcggacgtgg ctcttcaagc
1164061 cggcgcgacc ggagcgcgat cgtttactcg gcgaagacgt ggcagaaaag ctcgccagcg
1164121 agttggcgcg gctacgcgat gtctccacaa caagagggga agctcacccg tcgtgcaaat
1164181 gctgagcggg ggtctggtcg gtcagcgtga acccgaggct ggccgcgtgg tcgaacgatg
1164241 ggcacagcgc ctccacatac tttgtctcca gcggcggcac atggaccgcc cagttgcggt
1164301 cgtgacgatc accgtgggcg atcaatgcgt cgaacgcgag gtaggtcgaa agcgcggaac
1164361 gtgggtagga gcgcttggtc ggcaggtgct gcgaaccgag caagcgcctg ctggatcgcc
1164421 tcgacgttgt gcccacgttg cccgggatcg tcccggtcgc agttgagcac aacctcgggc
1164481 atcaatgctt gcggcaaccg cacgtccttg accagcgcac cgcgcacgcc gtcacggaca
1164541 gccagctgga ccggtgccgc aggtatcccg actagggcgt gtctcccaat ttcggagttc
1164601 ccactcgggc gtggatgacg gcgcaggcca gcaggacgcc gccgaggtag gtcagggcgt
1164661 atttgtcgta gcgggttgcg atgccgcgcc actgcttgag tcgatggaag ccgcgttcga
1164721 cggtgttgcg tagcccgtag agcgcggcgt cgaatgctgg tggccgcccg ccggcagacc
1164781 ccttggcctt gcgccggtcg atctgatctt ggcgttcggg gatggtgtgc ttgatcttct
1164841 tagaccgtaa tgcggcacgg gtacttgggt gtgagtaggc cttgtcggcg agtaagcgga
1164901 aatccgtgct gcccagggcg tattcggtgc tggcatggcg atagtcgtcg agcaggggca
1164961 gcagttgcgg gttgtcgccg gcctggcctg cggtcaaccg gatccgcacc ggggcttcgc
1165021 gctgatcggt cagggcatgg atcttggtgg tcagcccgcc gcgcgagcgg ccgatcgcat
1165081 gatcgtcggg ttcatcggcg gatttcttgt aatccgacag tgccccctgt ggcgagcgtg
1165141 tccgagcagg cgcccgccga atgctggtgt gcccgcacgt tcgtggaatc caccgacagc
1165201 agcttctcga tatcctcggc cacctcagcg tccaccccga acaccgcggc aacgtgggcg
1165261 aacacctcgt cgcaggtacc atccagcgac caacggtgat ggcgcttcca caccgtttgc
1165321 cacggcccga actcagcggg caggtcccgc cacggacttc ccgtacggaa ccgccacgcg
1165381 atcccttcca ggataagccg gtgatcgcta aaccgtctgc cgggcttgcc ctcatgcgac
1165441 ggcatcaacg gctcgaccac ggcccagaac tcgtccgaaa tcacacccac tcgcgtcacc
1165501 ggccaatcct cgctggccag tacctaaaaa tttgggagac acgccctagg cgcgggctgc
1165561 agcggtagta ctttggcctg ttcggcgcat ctcctatggc tgcggcccgc tggctcaaac
1165621 cttgccttgc cacgccaagc cattcctagc cttgcctagc cacaccatgc cctgcctaga
1165681 cacagcgagc ctacgccgcg tcgagttcgg cgaaaatcaa actgacccac taccaccgga
1165741 ttgaagggtt tggtgcgtgt tgatacgtcc cgggttgtgc ctatgggagg gtgtccatct
1165801 ccacgatgcc gccgaagtcg agttcgtcga gtgctcggat cacttcgctc gacgggatgc
1165861 cgcgatagaa gggtgccgcg ttcggtccgg tgcccgtcga cggtgcttcc gcagagtcct
1165921 cgaccacgag gccgatcaca cggccgtctt gcgcaacgat cggaccgccg ctgttgcccg
1165981 gccgcgcgat tgccgagtag aggaaaatct tctgccggcc ggggatagtc gtcgcggccg
1166041 ggttgaccac ctcgccacgc tgcaccgtga tcgccatctc cgcagtcatc ggcacccgcg
1166101 ggtaaccgaa cacgtagacc tcatccgccc agtcgggatc acggaacgcc atgccgccaa
1166161 gccgcgggat gtacttgcct tcgggcatct cgaatttgat tactgcgacg tcgagcgtgg
1166221 ggtgcgggtg agcggtgccc gagaagttca ccaactcggc ttcggcgtgg ttgcttgacg
1166281 gatagacgga cagacctgcg ctcgtgcccg cgagcccggt cacgacatgt ttgttggtga
1166341 tgacgtgatt gtggtcgacg acgaggccgg ttccccaact atccaccgga ttgccagcgt
1166401 cgtcgtgacc ggcgagttga acggtcaccg cgttgtagct cgggatgatg agctcggcac
1166461 cgaacacctc ggacaaccag aggttgccgc cacgctgtcc cttcgatatc gccccctgcg
1166521 agatgtactt ctgccccatg actggcaatc gcgggtccca accgagcggc agcagaagtc
1166581 ccgcgcgttc catcgagctg aggatgcggt ggagggtcac cgcgtcgccc gcggcgggca
1166641 ggccgagggt gctcaggtat cgggagaaat ctgcgaccga ccacggttcg aagggcaccg
1166701 tcgtcggcag accgatatcc gagtcaaccg gtggtggttc gggtttgccg atcgccgccg
1166761 caaccaccgg gttgtggacc agcccgaaga attgatgggc gcacatcgcc acgttcacac
1166821 gccacgcagg agtcccgggc ttcaggtcgg ccgccgtgag ctgtcgcggt caggtgcttt
1166881 ccgcgccatc cgccgtcacc tctgccatgg tccatctacg gtatctgcga caagggcagc
1166941 gtcgatgcct cgacatgcag agtcggtgtt cgcttcacgc gaactaggcg cgcctagcct
1167001 ggacgagtcc ccgggccgac attcgcccga ggccttggcc tccatcacct aattgtgtgc
1167061 aaaaccgtat ctaattgata cgattgcgca catggctatc tgggatcgcc tcgtcgaggt
1167121 tgccgccgag caacatggct acgtcacgac tcgcgatgcg cgagacatcg gcgtcgaccc
1167181 tgtgcagctc cgcctcctag cggggcgcgg acgtcttgag cgtgtcggcc gaggtgtgta
1167241 ccgggtgccc gtgctgccgc gtggtgagca cgacgatctc gcagccgcag tgtcgtggac
1167301 tttggggcgt ggcgttatct cgcatgagtc ggccttggcg cttcatgccc tcgctgacgt
1167361 gaacccgtcg cgcatccatc tcaccgtccc gcgcaacaac catccgcgtg cggccggggg
1167421 cgagctgtac cgagttcacc gccgcgacct ccaggcagcc cacgtcactt cggtcgacgg
1167481 aatacccgtc acgacggttg cgcgcaccat caaagactgc gtgaagacgg gcacggatcc
1167541 ttatcagctt cgggccgcga tcgagcgagc cgaagccgag ggcacgcttc gtcgtgggtc
1167601 agcagctgag ctacgcgctg cgctcgatga gaccactgcc ggattacgcg ctcggccgaa
1167661 gcgagcatcg gcgtgaccaa gccctattcg tcgccgccaa cgaacctgcg ctcactacga
1167721 gatcggctca cccaagtagc ggaacggcaa ggtgtcgtgt tcggtcgact gcagcggcat
1167781 gtcgcgatga ttgttgtcgc acagttcgcg gccacgctca ccgacgacac cggcgctccg
1167841 ctgctgttgg tcaaaggcgg atcgtcgctg gaactgcgcc ggggaattcc cgattcgcgg
1167901 acctccaaag acttcgacac ggtcgcacgt cgcgatatcg aattaatcca tgaacagctc
1167961 gctgacgcgg gcgagacggg gtgggaagga ttcactgcaa tcttcaccgc ccccgaagaa
1168021 atcgatgttc ctggtatgcc ggtcaagccg cgccgattca ccgccaagct gagctaccga
1168081 ggccgggctt tcgcaactgt tccgatcgag gtctcctccg tcgaagccgg caatgccgac
1168141 caattcgaca ccctcacctc agacgcgctc ggcctcgtgg gcgtacccgc agcagtcgcc
1168201 gtaccctgca tgaccattcc ctggcaaatc gcgcagaagc tgcacgcagt aactgccgtg
1168261 ctcgaagaac cgaaggtcaa cgaccgcgct cacgacctgg tggacttgca gcttcttgaa
1168321 ggactgttgc tcgatgccga cctcatgccg acgcgcagcg cgtgcatcgc gatattcgaa
1168381 gcgcgcgccc agcatccttg gccaccgaga gtcgccacgc tgccgcactg gccgctgatc
1168441 tatgcaggtg cgctggaggg gcttgaccac cttgaactcg ccaggacggt cgacgcggcg
1168501 gcccaggcag tgcagcgatt cgttgcgcgg attgatcggg cgacgaaaag atgagtgctg
1168561 gcgcggcctg cggcgcacgg gagaacacag ggaccacccc ggttccatag tcaacgtcag
1168621 cggtgcgggt gtcgatcaga cgacgaatgg aatcgccctc gcattcctcg cgatcgagtg
1168681 cctatgagcc gcgctcctgc ggcctaggcg agcgcttccg gggctctcag acatcggcct
1168741 cgtggcggtg tgcgcggcgg catgtggctc tgtgatctct tgcgcgagcg ccgattgcga
1168801 atttcgtccg gcgaaaagtg accgctccgt gaccttaatg caagaggtgt gtggtgtgga
1168861 gaggggcggg aggaagggag tgaggcgacg gtgtcgagat gcagcgagga ttggtggact
1168921 tccggtagtt gtttaacaag gccccggaga ccagggggcg agggagagcg cgggccgact
1168981 tgggtgggtg agcctggctt gggctggtgc gtgagcggag gatcgctggt ggccccgtag
1169041 ttggcgttgg cctgcggacg tgccgcgcct gcgagggatt cgtcaatctt cctgttgatg
1169101 tcgcccgtgc cacgtcggtg agatgtcgaa gggatgtgac ctggtgcgtt cgcgaacagc
1169161 tgctgaccac ggccaccgac ggcgctcaac tgtcgtcgat tccatcccac ccgtgcttgg
1169221 actttcaaac tgtccggcgc cgatggggaa acctggtgtt tggccggaac gtggcgccga
1169281 gcctcgataa tatcagcagt tacgtccagg ggtgtggtgt acgggcaggt aaggccggtg
1169341 ggcgtgtcgt agcccagtag tgggcggtca tcgcgtgatc cttcgaaacg accagcaaaa
1169401 gtcaatcgaa ggaaatgacg caatgacctc ttctcatctt atcgacgccg agcagcttct
1169461 ggctgaccaa ctcgcacagg cgagcccgga tctgctgcgc gggctgctct cgacgttcat
1169521 cgccgccttg atgggggctg aagccgacgc cctgtgcggg gcgggctacc gcgaacgcag
1169581 cgatgagcgg tccaatcagc gcaacggcta ccgccaccgt gatttcgaca cccgtgccgc
1169641 aaccatcgac gtcgcgatcc ccaagctgcg ccagggcagc tatttcccgg actggctgct
1169701 gcagcgccgc aagcgagctg aacgcgcact gaccagcgtg gtggcgacct gctacctgct
1169761 gggagtatcc actcgccgga tggagcgcct ggtcgaaaca cttggtgtga caaagctttc
1169821 caagtcgcaa gtgtcgatca tggccaaaga gctcgacgaa gccgtagagg cgtttcggac
1169881 ccgcccgctc gatgccggcc cgtatacctt cctcgccgcc gacgccctgg tgctcaaggt
1169941 gcgcgaggca ggccgcgtcg tcggggtgca caccttgatc gccaccggcg tcaacgccga
1170001 gggctaccga gagatcctgg gcatccaggt cacctccgcc gaggacgggg ccggctggct
1170061 ggcgttcttc cgcgacctgg tcgcccgcgg cctgtccggg gtcgcgctgg tcaccagcga
1170121 cgcccacgcc ggcctggtgg ccgcgatcgg cgccaccctg cccgcagcgg cctggcagcg
1170181 ctgcagaacc cactacgcag ccaatctgat ggcagccacc ccgaagccct cctggccgtg
1170241 ggtgcgcacc ctgctgcact ccatctacga ccagcccgac gccgaatcag ttgttgccca
1170301 atatgatcgg gtactcgacg ctctgaccga caaactcccc gcggtggccg agcacctcga
1170361 caccgcccgc accgacctgc tggcgttcac cgccttcccc aagcagatct ggcgccaaat
1170421 ctggtccaac aacccccagg aacgcctcaa ccgagaggta cgacgccgaa ccgacgtcgt
1170481 gggcatcttc cccgaccgcg cctcgatcat ccgcctcgtc ggagccgtcc tcgccgaaca
1170541 acacgacgaa tggatcgaag gacggcgcta cctgggcctc gaggtcctca cccgagcccg
1170601 agcagcactg accagcaccg aagaacccgc caagcagcaa accaccaaca ccccagcact
1170661 gaccacctag actgccaccc gaaggatcac gcgaggaacc ttcactcgta caccacgtcc
1170721 ctggccttgg ccgaaggtag aacgccagca cgacttgctg ttgtcaactc ttgcgagtta
1170781 cgtgagtgcg gccggagcac acgctcgtat cgtcgtcaca gtcgaagggc gcgatcttga
1170841 gttcgacgta tcgaccttcg cccttgtggg cccgcagcag ctgcccgaag tcgagccgtc
1170901 gcagtagtga ccgggggccc agttagcgat ggctttgtca ctgtggaggg tctccctccc
1170961 gtagtgatgc accactcgca cgagagccaa ttcggccgcc cgtcgcgccg cagcagagcg
1171021 cggtggctct tcgtcgttca tttggtcatc gcctcgcgta gatgttccgc cgcgtcttcg
1171081 ccgcggacgc cggccgtgcg taggtcggcg tataccctcg gccataacat cgacctaaac
1171141 ccctgcaggt tctgttcggt cagccgggcg cacgctgggg tcgggaagaa gcgcaatatc
1171201 aaccgaccgc cggcgatttc ctgcaatccc gcagccattg ctgcacggcg aagatcgctc
1171261 catgatcgcc cgggcacgta gatttccatc ggagctattt ccgtctgcat tggcgcgagc
1171321 aggctcgccg acaacgcgct tgtggctgcc cactcaatgc ctgcggcatc ccacaactgg
1171381 ccggccttga ccacgccggc agtcggatcg cgccacagca caccagtcga aatagaaatc
1171441 ggcgaccgaa gcttgtctgc tgcctcagcg tatgcatcca acagcgcatc gcgatcaacg
1171501 atcaggcgcg ccgatttcgg gccgcgggca gtggcactgg ccagatggcc gtttttttcg
1171561 agaaacttca acgcctgagc gctgcttccc atcgagagac cggtggcctc tacaaccgag
1171621 gcgacagttg gaccggcgat gttcgccagc agcgcttcac atacggcaag tgtggcgcgg
1171681 cgccagccta tgcgcgcgtc gagtggggca ggtggcgcgc ctttcgtctc gatcaccaga
1171741 gtggttccag ttgatgtgtt tcggtagtgg atatcggcag cgcccgactc gtccacccac
1171801 ccaacaccgg cgtcatgtgc cgccttccgg gcaccaggag acatcgtggg tgcagccaaa
1171861 atgtcgggcc gggatgtggc gtggagtgcc tcggctacct gacggggcca accagtcgtg
1171921 agccagcgaa ccaggaactc tgcgccgtcg agcgacacaa tcacgtcgcg atgagggccg
1171981 tttacgcgtc gtgcgcgcac ttcgctgcga aacgcgcctt ccagcgcact cacggtgcgt
1172041 tcgtcccaag acatggaggc atcatacttc actaagggac gatactctac tgtttcagtg
1172101 aagtaccatc tacggatgaa gttcgattgc cacgtgcgat ccgacgcttg cacttcgctg
1172161 gcgggccgcg aacccgatca gctcctccag gtcgtcggca cgggtcagca aggcggcgct
1172221 gtccgggtgg gcgcgcatgc caaacaccag tcgctcaccg tcggggtcaa gcaacaccag
1172281 gtcgcggagc atggtggcgg gcggaaccca cacttcgggc tagctctagg gggcagggct
1172341 ttgacgggtc ttgacaaata cgtgtagcta cacgagtctg gagtaatggg caaaggggcg
1172401 gcgttcgacg aatgcgcttg ctacaccacc cggcgggcgg cccgacagct cggccaggcc
1172461 tatgatcgcg cgctgcggcc gagcgggttg acgaacaccc aattcagcac gctggccgtg
1172521 atctcgctgt cggaaggcag cgccgggatc gacctcacga tgagcgagct tgccgcccgc
1172581 atcggcgttg aacgcacgac gctaacccgc aacctcgagg tgatgaggcg cgacggactg
1172641 gtgcgggtca tggcgggtgc cgacgcgcgg tgcaagcgca tcgagctgac cgcgaagggc
1172701 cgcgcggcac tgcaaaaggc ggtgccccta tggcgcgggg tgcaggcgga ggtgaccgca
1172761 agcgtcggtg actggccacg ggtgcgacgc gacatcgcga atctgggtca ggcggcggag
1172821 gcgtgtcggt gatctttttt gcgcatatat gtgtagttac acccaactga ggagcaaatg
1172881 atggctaggc agagatttcg tgaccaggtg gtgttgatca ccggtgcctc cagcggcatc
1172941 ggggaggcga ccgcgaaggc attcgcccgt gagggcgccg tggtcgcctt ggcggcgcgc
1173001 cgcgagggtg cgttgcgccg ggttgcccgg gagatcgagg ccgcgggtgg gcgggcgatg
1173061 gtcgccccgc tcgacgtctc gtcgtcggag agcgtgcgcg ccatggttgc cgacgtggtc
1173121 ggcgagtttg gtcgcattga cgtcgtgttc aacaacgccg gcgtctcgct ggtaggcccg
1173181 gtcgacgcag agaccttcct tgacgacact cgcgagatgc tggagatcga ctacctcggc
1173241 acggtgcgcg tggtgcggga ggtcttgccg atcatgaagc agcaacgatc gggacggatc
1173301 atgaacatgt cgtcggtggt gggtcgcaag gcctttgcgc gattcgccgg ctactcctcc
1173361 gccatgcacg cgatcgccgg tttctccgat gcgttgcgcc aagagctgcg gggtagcgga
1173421 atcgccgtct cggtgatcca cccggcgctg acccagacac cgctgttggc caacgtcgac
1173481 cccgccgaca tgccgccgcc gtttcgcagc ctcacgccca ttcccgttca ctgggtcgcg
1173541 gcagcggtgc ttgacggtgt ggcgcggcgg cgcgcccgcg tagtcgttcc atttcagccg
1173601 cggctgctca tggtgggtga cgcgttctcg ccgcggtacg gcgaccgggt ggtccgcttg
1173661 ctcgagagca agatattcgg tcgcctgatc ggttcctatc ggggttcggt ataccgccat
1173721 cagccgaccg aatcagcgaa ggcacaggcg gcccagcccg agcgcgggta ctcgtcggcc
1173781 cggtgaggtt ggttggagcc aggctccacg tcgctgaggc gagcggcgtg cgcagcgcgt
1173841 agcggctcgt cggcacggtg tcgatggtct ccttggcgct gaatcgcgac gtgctggcga
1173901 tcacccgggc aagccgatca cgcagttcgt cgtcgggcgc cagctcaacg tcgagttgcg
1173961 ctctcccgct ttgagatcca gcgcgacacc tcgtcgcgcc ggtacacgac gcgccgtccc
1174021 aaggtgaagc tcgccggtcc gatgtccgag tgccgccagt gccgtagagt gccgacggga
1174081 acgccgatca tctccgaaac ttgttttgcg tccagcagat ccatgtttct cctcccgaca
1174141 tgggctggtt tccaatgtct ccaacagtgc tggcagcgtc cgtgttcggt cgcccatttc
1174201 gcttgcgcga ctgcgccata accggccagg tgaggcgcga cgggttcgag agtggcgccg
1174261 cggtattgtg cgactgccct ggccgagcgg agcagctcgt cgtcgtcgat gccccggcgg
1174321 tcgagttgga cgatgtcgac gtagtcccgc cagcgggtgc tggtgatgcc gcgttcgagg
1174381 atggtcactc ccttctcggc gatgatggtc tcgggcgcgt agcccaggag tgtgatcggc
1174441 tcgccgagga tccggtcgat ggtcacccgt gtgggccacg gcgcgatcgg ttcgccggtg
1174501 gacacatccc aggccgcgat gccctgccac ggtccgaccg acatagcgac tcgcacgcgc
1174561 aggcccgggt agtcggcccg ctcgcgaatt tcctgcacgc tgctcgtgtc gaggttgaac
1174621 gccaccccgt cgtcgatgtc gatcacggcg atgtcgcgaa ccacctgggt gagatgctcg
1174681 gcggtgacgt cggcgcgcat ggcgttggag tcggtgtcct tcgtcgggtg ccgaacgccg
1174741 taggcggcca gcaggatccg gcctttgagg acgaagtctg cggcatgcga ggtgcgggtg
1174801 agccgatcca ggaacgattc gagggtgtgt cgagtcaggt actcctgcgt cggtgcgccg
1174861 gtcccgcact tcgaggcagt agaacgagcg aggattggat ccggcgggac accgtgtcgc
1174921 cggagctcac gccagcatcg ccaatgtttg taagaccggg gacttctccc gcggtaggcg
1174981 ggtggcgatc tcgatcagcc gggcgggttt gccgcctcgg cgcagccact ctcgcagcgc
1175041 gtcacgcgcc agttcgtaac cgacttcgta gcggagccgg aatgtatcgg cgatcgagcg
1175101 ctcgggtgag ttagattccg attgtctgat ccgatcccgg gatcgtgatc tcgtcgcgtc
1175161 cgatctaaaa tgtggcccgg tcgaagtggt gccacgcaat cgcgcctgtg ctggccggtg
1175221 tcctcgacca gcgggggatg gcgatgtcca gcgcggcggg gatcgcgtcg gtcaggtcgt
1175281 ggtgcgtgag tgcggaggcc aggcagatcg tagcgtcggg gcggcgcgtg gcggcctcga
1175341 tccgatccca gtcggcggtc gacgcgtcta cgggtaggta gatgccgcgg gcgatgcggt
1175401 cccagcggcc tgcctgcgcg ccgcggtaaa gcgcgctgcg cgaggccggc ccgccccgca
1175461 gtgctcggtg tcagggcttc cacggcgcct atcccactcg tctttggtac ggaacgtagg
1175521 cagataactc tatgtgtaga cgtttcgtat cgatgcctga ggaaatcggg aacaggcccc
1175581 gcgggcgcat ggctattggg agtacggcgg ggcactgaca ttgcgaggcc accgtcggtt
1175641 ggcgccggta gcatggggat ttgtcgatgc ttggtgaagg agcaaccgtg ggcggtgaga
1175701 cgcctaagaa ggtggtcgtc tcatggactg ctgtgaagaa cgcggggtcg cgcgccacaa
1175761 gggcctcagc caagttggaa cgccgggttg tccccgttgg tcacaagcgg tcagctgccg
1175821 ttgcagcgca tatcgagaag cagcggtcac cgcagtccag atgccgctga cgcccggcta
1175881 cggtgagacc ccgcttccgc acgacgaact ggccgcgttg ctccccgagg ttgtcgaggt
1175941 gttggacaag ccgatcacgc gcgctgatgt ttatgacctc gaacagggcc ttcaggacca
1176001 ggttttcgat ctattgatgc cgacggctgt tgaaggctcg ttgtcgcttg atgagcttct
1176061 cagtgaccat ttcgtccgcg atctccacgc gcgtatgttt ggtccggtat aggactgggc
1176121 cgggcggtgg tgacgacgtg aactcaacat cggtgttgca ccggagcagg tcgccgtcga
1176181 ggtacgcaac gcgctcgaca ccatcgcgta ccgctgggtg cacaccgatg attggaccgg
1176241 tcggcaactg ggtattgttg ttcatgcaga ccttgtgcga atccatccgt tcaccgatgg
1176301 aaatgggcgc accacaaggc ttctcgctga tttggtgtac gcgacggttc agaatcccac
1176361 cgagctgcag tatgactggg agctcgataa actgcgctta cgtcgaacta cttcgcggct
1176421 acgaccgaga ccgggacatt gcggcgctcg ccgccttcat cggtgtgcgg cccatcgaga
1176481 cataggcagg ctgtcttgtt gaagccggcg accgggcgac ccaagcggag gaggtaccgc
1176541 ggatcactgc ggtaccgtcg acgcggtggc aaccaggcat caacgggcgg ggattgacga
1176601 ccgctggcat aagcgggtca aagggccgga cgggaacagg cgaaccgtgc ggtctgctgt
1176661 ctgcggcagg gtttcgcgct ggcgcgtcag gtgggttgac ggcggcggag aggagcacag
1176721 caagagcttc cagcgcaaac ctgacgcgca ggtacctgac ccatgccgaa ctgttgatgc
1176781 tcgccagggc cacgggccgg ttcgaaacgc tcaccttggt gctcggctac tgcggcttac
1176841 ggcggtttac ggttcggtga ggctgttgcc ctgcggcgca agcatgtggg ggatcgcgtg
1176901 ctgaccgtcc gatcgtcccc tacggcggtg accggcaagg gcatcgttga gtcgacgacc
1176961 aagacgaagc gggatcgtca cgtaccagtg cctgagcctg tttggcgcag gctccatgcc
1177021 gagttgccca ccgacccgaa cgccttggtg ttccccggcc gtaagggcgg attcctgcct
1177081 ctcggtgaat accgctgggc attcgacaac gccggcgacc aggtcgggat cgaaggctgg
1177141 taccgcacgg tctggggcac accacggcct cgctggcgat cagcgcaggc gctaacgtca
1177201 aggtcgtgca acggctcctt ggacacgcag cagcggcgat gacgctcgac cggcacggcc
1177261 atctgctcaa cgacgatcta gcggtgtggc cgatgcgctg tgcaaagtca tcgagaacac
1177321 tgcggtatca ctgcggtatg cggagacgga acagagtcgg gctccgggca tgagatagcg
1177381 cgtctgaact gcaacgcccc catagcccaa ttggcagagg cagcggactt aaaatccgtc
1177441 aagtgtcggt tcgagtccga ctgggggcac ggggaaatcg ttgttggcaa gtcatggcgt
1177501 tgggcactgc tgctgctcgc cgctcaagcc agcaacccaa cctggcgata cgttggtttg
1177561 agcggggcga ctcccgtcgg gccacctacg ccccgcctgt tgctatggcc ggacaaggag
1177621 catcgcgatg agcgtggatt acccccaaat ggctgctacc cggggaagaa tagaaccggc
1177681 cccgcggcga gttcgcggct atctcggaca tgtgctcgtc ttcgacacca gtgcggcgcg
1177741 ctatgtctgg gaggttccct actacccgca gtactacatc ccgctggcgg atgtccgcat
1177801 ggagttcctg cgcgacgaga accacccgca gcgagtgcag ctgggtccgt cgcggctgca
1177861 ctccttggta agcgccggtc agacccaccg atcggcggcg cgggtattcg atgtcgacgg
1177921 cgacagcccg gtggcgggca ccgtgcgttt caactgggat ccgctgcggt ggttcgagga
1177981 ggacgagccg atctacggcc atccgcgcaa tccctatcag cgggccgatg cgctgcgctc
1178041 gcaccgacac gtccgtgtcg agctggacgg cattgtgctc gctgacaccc gatcgcccgt
1178101 tctgctattc gaaactggga tacccacaag gtattacatc gatccggccg acatcgcttt
1178161 cgagcatctg gagcccacct cgacgcagac gttgtgtccg tacaagggga cgacgtcggg
1178221 ctattggtct gtgcgcgtcg gcgacgccgt gcaccgcgac ctggcctgga cgtatcacta
1178281 tccactgccc gccgttgccc cgatcgccgg cctggtggcg ttttacaacg agaaggtcga
1178341 cctcaccgtc gacggcgtcg ccctgccgcg gccgcacact cagttcagct agtgcttggt
1178401 ttgttcgccg gttggcggcc gccagcatgg tcaacctcat ctagggcgtg ggtgtcgggg
1178461 cgcagcaggc tgccggcgat ctcgcggaca ccgtcttggc tgtgcccaat ctagattccg
1178521 atcggcctga gtcttcttct gccggcgcag cgcatcggcg cgggccacga ttgcatcgac
1178581 gtggacggcc agccggcgct gggtcatcga cggccagcga gccgccctga gagcgagctc
1178641 ggcggccacg gcgccaacac ctcaccgtcg acggtcagat cgctgcgaca cacgatcgtt
1178701 tgaaacatcc ggtagtcgat gtcgccggcg gtgaagactt ggccgaccat ggctaggcac
1178761 tcgcgcatac cgcagctggc tggccgttgg cccctggctg atccgcaagg ccgcaccgac
1178821 ctcagcgatc accgccgcct gtgaccacta accagtctca tcgaaaatat attcgataca
1178881 gccacttgcc gtcgacattg accatgaggc gttcacgtcg cagggccgac gaaatatgct
1178941 gagacctgcc tactcgtgtg caatgtgata ttagcctcat tttgatttga attatgagaa
1179001 tttcttattt cccagttatg gggagcgtgt gctggttgtt agcgaagtac gctaaaactg
1179061 cagttactgc tcatagcact ggtttgccac ataccccgta tcgggatacg tcatgatcgg
1179121 tatcctgagc ggaacataag tcggtcacgt gacctaggta acagcgtcta attcgtgaaa
1179181 tttttgatca gaatttggtc gctagactta ttccagccca gtatgaatca gcgcttttgg
1179241 tgccgaaatg cggcgaatcc cgggcagtcg gcgtcgcaca gcacggttgc tgtgctgtcg
1179301 caagcctgga ggcccgcaga cacagcaagc gaggagcggc gcgtatgagc cgcgccggcg
1179361 acgatgcgga acgaagtgat gaggaggagc ggcgcatgag cgttatgaac ggccgggagg
1179421 tcgctcgaga gagcagagat gcccaggtct tcgagttcgg caccgcaccg ggctccgccg
1179481 tggtcaagat tccggtgcag ggcggtccga tcggtggcat cgccatcagc cgcgacggca
1179541 gtctgctggt agtgaccaac aacggcaccg acaccgtctc ggtcgtcggc accgacacct
1179601 gccgggtcac ccagaccgtc accagtgtca acgaaccgtt cgcgatcgcc atgggcaatg
1179661 cggaagccaa ccgcgcgtac gtcagcacgg tgtcgtcggc gtacgacgcg atcgcggtca
1179721 tcgacgtggc cacgaacacc gttctcggca cccatccgct ggcgctcagt gtgagcgacc
1179781 tgacactcag cccggacgac aagtacctgt acgtcagccg aaatggcact cgcggtgctg
1179841 acgttgcggt gctggacacg acgacgggcg cactgatcga cgtcgtagac gtttcccagg
1179901 cgccgggcac caccacgcaa tgcgtgcgga tgagcccgga cggaagtgtc ctgtacgtcg
1179961 gcgccaatgg gccatccggc ggcctgctcg tcgtgatcac gacccgcgcg cagtccgacg
1180021 ggggacgcat cgggagtcgc tcgcgttcgc ggcagaagag ctccaaaccc cggggtaacc
1180081 aggcggcggc gggcttgcgc gtggtggcga ccatcgacat cgggtcatcg gtccgcgacg
1180141 tcgcgctcag ccccgacggt gccatcgcct acgtcgccag ctgcggctcc gacttcgggg
1180201 cagtggtcga cgtcatcgac actcgcaccc accagatcac cagctcgcgc gcgatcagcg
1180261 agatcggcgg gttggtcacc cgggtgagcg ttagcggcga cgcggatcgc gcctacttgg
1180321 tcagcgagga tcgggtgacc gtgctgtgca cccgtacgca cgatgtcatc ggcacgatca
1180381 ggaccggcca gccgtcgtgc gtggtcgaga gcccggacgg aaagtacctg tacatcgccg
1180441 actactccgg caccatcacc aggacagcgg ttgcctcgac catcgtgtcc gggaccgagc
1180501 agctggcgct acagcgccgc gggtctatgc agtggttctc gcctgagctg cagcagtacg
1180561 cgccggcgct cgcctagctc gaacgcgctt ctcgggggaa cccgtttctc atgacttctc
1180621 gcggcgatag cattcgcccg aggaggacat gaggcgcgcc gagacccgta aggcggtaca
1180681 tcgatgtacg gcacgatgca ggactttccg ttgacgatca ccgcgatcat gcgccacggc
1180741 tgcggtgtcc acgggcgacg cacggtcacc accgcgacgg gtgagggcta tcggcacagt
1180801 agctatcgcg atgtggggca acgagctggc cagctggcaa atgcgttgcg ccgcctcggt
1180861 gttaccgggg accagcgggt tgccacgttc atgtggaaca acaccgaaca cttggtgacc
1180921 tacttcgcgg tcccgtcgat gggcgcggtg ctgcataccc tcaacatccg gctcttcccc
1180981 gagcagatcg cctatgtcac caacgaggcc gaagaccgcg tcattctggt cgacttgtca
1181041 ttggccagac tgctcgcgcc ggtgctgccc aaactcgaca ccgtgcatac cgtgatcgcg
1181101 gtaggagagg gcgacacgac gccgctgcgg gaagctggca agaccgtgct gcgcttcgcc
1181161 gaattaattg acgccgaatc ccccgacttc gggtggccgc agatcgatga gaactccgcg
1181221 gccgcaatgt gttacaccag cggtactacc ggcaatccca aaggcgttgt atacagccat
1181281 cgttcgagct ttctgcacac gatggcggcc tgcaccacaa acggtatcgg ggtcgggtcc
1181341 agtgacaagg tgctgccgat cgtgccgatg tttcatgcca acgggtgggg gctaccgtat
1181401 gcggccttga tggcgggtgc ggacttggtg ctacccgatc ggcatctcga cgcccgctcg
1181461 ctgatccaca tggtggagac gctgaagccg acgttggccg gcgcggtgcc aaccatctgg
1181521 aacgacgtca tgcattacct agagaaggac cccgatcacg acatgtcatc gctgcgtctg
1181581 gtcgcctgcg gcggatcggc ggttccggaa tcgctgatgc gcaccttcga ggacaagcac
1181641 gatgtccaga ttcggcagct gtggggcatg acggaaacat cgccgctggc caccatggcc
1181701 tggccgccac ctggcacccc ggacgaccag cattgggcat tccgcatcac tcagggccaa
1181761 ccggtgtgcg gggtggagac ccggatcgtc gacgacgatg gccaggtgct gcccaacgac
1181821 ggcaacgccg ttggcgaggt ggaggttcgc gggccctgga ttgctggctc gtattacggg
1181881 ggacgtgacg agtccaagtt cgattccggc tggttgcgca ccggtgacgt cggccgcatc
1181941 gacgagcaag gcttcatcac cctgaccgac cgcgccaaag acgtcatcaa gtccggcggt
1182001 gaatggatct cctcggttga gttggagaac tgccttatcg cgcacccgga cgtgctcgag
1182061 gccgcggtcg tcggcgttcc cgacgagcgc tggcaggaac ggccgctggc ggttgtcgta
1182121 gttcgggaag gggccaccgt tagtgctggt gatctgcgag cattcctggc ggacaaggtc
1182181 gttcgctggt ggttgccgga gcggtgggcg tttgtcgacg agattccccg caccagcgtg
1182241 ggcaagtacg acaagaaggc catccgttct cgctacgccg aaggtgccta ccagatcacc
1182301 gaggtgcaca cttgacccgc gcgagcagac gcaaaatcgc ccattttcgt gtcgaaatgg
1182361 gggcttttgc gtctgctcgc gggtagaaag gtgaccatga gcctgcgggt cattcaatgg
1182421 gcgacgggat cggtcggtgt ggcggcgatc aaaggcgtgc tgcagcatcc cgaactcgaa
1182481 ctcgtaggct gctgggtgca ttcggcggcc aagagcggca aagacgtcgg cgaaatcatc
1182541 ggttcaccac cattgggcgt gatcgcgact aacagcatcg acgacgtttt ggcgctggac
1182601 gccgacgcgg tgatctacgc gccattgctg cccagcgtcg acgaagtcgc cgcgctgttg
1182661 cgttcgggca agaacgtggt cactccgctt gggtggttct atccgagtga aaaggaggcc
1182721 gccccactgg aagtcgccgc gcaggccggc aatgcgacgc tgcacggcgc cggaattggg
1182781 cccggggctg tcaccgagct gttcccgttg ctcctgtcgg tgatgtccac cggtgtgact
1182841 tttgttcgct ccgaagagtt ttcggatctg cgcagctatg gagcgccgga cgtgctgcgc
1182901 tatgtgatgg gtttcggcgg cacaccggac agcgcgttga ccggaccgat gcagaaaatt
1182961 ctggacgggg gcttcctgca gtcggtacgg ctgtgtgtcg accggttggg ctttgccgcc
1183021 gacccccaga tccgcacttc gcaggaggtg gcggttgcga ccgccccgat cgactcgccg
1183081 atcggagtaa ttgagcccgg acaggtggcc ggacgccgct tccattggga ggcgctggtc
1183141 gaggacacag tggtcgtcca gatcgccgtg aactggttga tgggatcgga aaatctggat
1183201 cccccttggt cattcgggcc ggccggagaa cgctacgaga tcgaagtgcg cggcagcccg
1183261 gacacctgcg tcaccatcaa gggttggcaa ccgcagaccg tggcggccgg cttgaagagc
1183321 aaccccggga tcgtggcaac cgcggcgcac tgcgtcaacg cgatcccggc aacctgcgcc
1183381 gccccggcgg ggatccagag ctttttcgac ctgccgctca tcaccggccg ggccgctccc
1183441 gggctggcac gctagagttg ctggcggcgt ccccggccgg gatgtcgaga atcggacggg
1183501 taatccaatg gcaaagtctg tcgtcgtcga gcaatcgcga gcgattccgg tgcaatccga
1183561 ggatgcgttc ggtggcacgc tggcggcagc gctgccggtg atttgttcgc actggtacgg
1183621 cctgatccca ccaatcaagg aggtccggga tcaaacgggt gcttgggatt ctgtcggaca
1183681 ggcccgtgtc atcacgatgg tcggcggcgg gcgcgtgcgc gaggagctga ccagtgtcga
1183741 cccgccgcgg tcgttcggct acacgctcac cgacatcaag ggcccgttgg cgccgctggt
1183801 cgcgttggtg gagggcaagt ggagcttcgc tcccgcggat accggaacca cggtgacctg
1183861 gcaatggacc atccatccta gatcggcgct ggccgcgccg gtgttgccgg tgttcgccag
1183921 gatgtggcgg ggctacgcgc gcggggtgct cgagaagctt tccgctttgt tggtgggctg
1183981 agcggcgctg ccggcttcgt ctaccgtcgg ggtcatgtgc cgactctttg gcttgcactc
1184041 cggaaccgat gctgtcaccg cgacgttttg gttgctgaac gcctcggata gcctggccga
1184101 gcaaagccga cgaaaccccg acggcaccgg ccttggtgta ttcgacgaac accaccagcc
1184161 gcggctacac aagcaaccaa tagcggcctg gcaagacgcc gacttcgcca ccgaagccca
1184221 cgagctgacc ggcacgacgt tcgtcgccca tgttcgctac gcgacgaccg ggtcgctcga
1184281 catccgcaat acccacccat tcctgcaaga cgggcggatc ttcgcacaca atggggtggt
1184341 cgaaggactg gatgtcctcg acgaacggct gcgcgaggtc ggcgccgatg acctggtgtt
1184401 gggccagacc gactccgagc gcgtattcgc tttgatcacc gcttcgatcc gcgcccggga
1184461 cggcaacgaa tcagccggtc tgattgacgc gctgaggtgg ctcgcggcga atgtgccgat
1184521 ctatgccgtc aacgtgttgc tcagcaccgc gaccgatgta tgggcactgc ggtatccgga
1184581 gtcccacgag ctgtatatct tggaccgccg cggcgacggt gcgcccgagt tccacttgcg
1184641 aagcaagcga atccgcgcac actcgacgca cttgcgcgaa cggtcgtcgg tggtgttcgc
1184701 gactgaaccg atggatgaca acccgcgttg gcgcctgctg gacgcggggg agctggtcca
1184761 cgtggacgcc gccctgcggg tcaacaggag tctggtgcta cctgatccac ccagacatcc
1184821 gattcgccgg gaagatctca gcgagccggt actgcatgcg caacacacgt cggcgtgaac
1184881 tcgtgacaac tagacgcgcg ctggtattgg ccggcggagg actggccgga atcgcctggg
1184941 aaacaggtgt tttgcgcggc atcgcggacg aatcgccggc ggcggcccgg ctgctactgg
1185001 attcggatgt gttggtcggg acatcggccg gtgcaacggt cgccgcgcag atcagcagtg
1185061 gctgcccgct cgacacgctg tacgaacggc agctcgccga gacgtcggcc gagatcgatc
1185121 ccggtgtcga catcgatgcc atcactgatc ttttcctgac tgccgtgacc gagccgcaca
1185181 tttcgacgcg ccggcggcta caacggatcg gtgccgtggc gttggcggtc gacaccgttc
1185241 cggagtccgt ccgccgtcag gtgatcgccc agcgcttgcc gtcgcacgac tggccggacc
1185301 gggtgttgcg ggtcaccgcg atcgacatcg ccaccggcga attggttgtt ttccatcgcg
1185361 agtcgaatgt ggcgctggtc gacgcggtgg cggccagttg ctcggtgccg ggggcgtggc
1185421 ctccggtgac aattgccggc cgccgctaca tggatggcgg ggtggccagc tcggtcaacc
1185481 ttggtgtcgc cgacgattgt gatgccgccg tggttttggt gcccgccggc gccgacgcgc
1185541 cgtcgccctt tggcggcggg gcggccgcgg agatcgcggc agccaccggc atggtgtttg
1185601 ccgtgttcgc cgacgacgac tcgttggcgg ctttcgggcc caacccgctg gatccgctct
1185661 gccgtgtgaa ctcggcgatg gccggacgtc agcagggccg ccgcgaagcg caagccgttg
1185721 ccaggctgct cggcgtttga tcagccctcg atggtcgcag cggcagattc gtcgtcgtcg
1185781 atctcgaatg cttccaaggc ttgggtggcc agcgcgcggc cgacggcgat cacctccacc
1185841 gcgcggtgaa attccaggct tcggcacgtt gaacgcggta cctcgatcag caggtcggcc
1185901 ggatagcccg ccagcgtatg gcgcgccagt gcggattggg cgatatcgat cgtccgattc
1185961 atcacctcga aactgcccat tttgggtagc ccgggtgtgt cagcggcttc ctcgcggtca
1186021 gctggtgggc cggctggacg ctgctcgatc tccggagctt gcgaccagga atccgattcc
1186081 gcggccgccg cgccgaagcg actcagcacc gcccgcgccg taggccggtc gagcagcgac
1186141 cgggcggcgc tgacgtcaaa cagcgcggaa gtgctgcgca ccatgcggtt caaccactcg
1186201 gcggtgacgt tgggctccgc atcgcgagcg gggccggcct cactgccgtt aaggctgacc
1186261 gcgatggtca ggtcggcgtt gaccccggcg atcggcgcca tcggcagtgg atccaggatt
1186321 ccgccgtcgg ccagcaggcg tccgtcgact tcgtgtgggg cgatcacccc gggtatggcg
1186381 atggacgccc ggatcgccgc gtcgaggggg ccgcgctgaa accacaccga cttgccggcc
1186441 agtaggtcgg tggccaccgc ggtatagggg atcggcagct gctcgatggc gaccgggccg
1186501 acgatgtcgc gcaccgcgtc gagaatcttt tctgcccgca ggatgccggc cgcgctaata
1186561 gacggatcca gcagccgcaa gatggtgcgc tgcgtcaggg acttggccca gtgggcgaac
1186621 tcgtcgagtc ggccggccgc atgcacccca ccgaccaccg cgcccatcga cgagccggcg
1186681 atcccaacga tgtcatagcc gcgctcccgc agcgcctgga tcactccgat gtgggcgtaa
1186741 ccccgggcgc cgccgctgcc gagcgccagt gcgacgcgcg gcgaagacga ccctcgcacc
1186801 cggagggcag ctggtgcggg catgctttca ttctgctcgg cgaggtgccc ttatcgggat
1186861 ccggccacta gtttcttgca cccctgatct caattgccga gcgttatccg cattccgcgt
1186921 tggcggcggc gcgcgccgcg acgatcacgg ccgcctgccg tgccggggtc agcgccgccc
1186981 agcggatgtg ccagctgccg gcaactccgg atggcgatgc ttggaccacc gccagatacg
1187041 gctcgattaa cgactcgccg gagccgggct gggcatccat ccacagcctt gcggcgtgac
1187101 aggcctggta atactcctcc tcggtcgatt ccgcgggagc gtcaaccctg gtggtcacgc
1187161 cggccgggga gacgccgacg acgcccgccg gcaacgtacc ggcaacgctt gacgaacgtc
1187221 cggctttgct gctgccgccg cgagagcagc cggcaacggc cgacaaccac gccagcgcca
1187281 aaaccattgc gcacagcagg ggggcataac ggctcgggcg caccgtccca atctatgcaa
1187341 gactgaccgc gtgatggagc gctacggatt ttgtgggtgt tgtcggccct gacctgccgt
1187401 ccgccctgtc cgttcgactc tttggagttc tcccgtggtt atgcctcttg tcacgccaac
1187461 caccgcggtt ccatcaccgg gacccacacg gctgcgtgta gccgatctcc tgcgcgccac
1187521 cgaccaagcc gcagacgacg tgcttggcgg gcgctgcgac cacctgctac ccgacggtgg
1187581 tgtcccgcag acgcagcgct ggtacacccg catccacggt gacgaggagc tggatatctg
1187641 gctgattagc tgggttcccg gtcaaccgac cgagctgcac gaccatggcg ggtccctggg
1187701 agcgttgacc gtgctgagcg ggtcgctcaa cgaatatcgt tgggacggcc gtcggttgcg
1187761 acggcgccgc ctcgatgccg gtgatcaggc agggttcccg ttgggttggg tgcacgacgt
1187821 ggtgtgggcg ccccggccga ttggggggcc tgatgcggcc gggatggctg tggcgccaac
1187881 cctgagcgtg cacgcctact cgccgccgct gacggcgatg tcgtactacg agatcaccga
1187941 acgcaacacg ctgcgccgcc agcgcaccga attgaccgac cagcccgaag ggtcgggatg
1188001 agccgaatcg accgggtgct ggaggccgct cgccgccggt atcggcgcct tgcggccgac
1188061 caggtgcccg aggcggcgcg gcgcggcgcg gtgctcgtcg acatccggcc ccaagcccag
1188121 cgggcccggg agggcgaggt gccaggggcg ctagtgatcg agcgcaacgt cttggaatgg
1188181 cgctgcgatc ccaccagcga cgcccggctg ccccaggccg tcgacgacga cgtcgagtgg
1188241 gtgatcctgt gctcggaggg ctacacctcg agcctggcgg cagcgtcgct gctggacttg
1188301 gggttgcacc gggccaccga tgtcgtcggt ggctatcgtg cgctggcggc cggcggcgtg
1188361 ctggccgagc ttggtggtgc cgtgggcggg tagtttggct cgccgctgct ggctgggtcg
1188421 ttactgcccc ggcgtgccgg cgttgccgaa gatgagtcct cgagttccgc cggcgccgcc
1188481 ggcgccgtcg agtccggcga tcaggccggc gccacccttg ccgccgttgc cgccgttgcc
1188541 gccgtcaccg accaactggg cgtcgccgcc cttgccgccg ttgccgccgt tgccgccgtt
1188601 gccgtcgaca ccgccggcgg cggcgcccag accgccttgg ccgccgcccc cgccgttgcc
1188661 gccggtgccg ccgccgccga gcaggccggc gccgccgccg ttgccgccgt gaccgcccgc
1188721 gtgaccgctg ccgccgttac cgccggcggc ttgaagcccg gtcggcgggt tggtgccgcc
1188781 gctgccgccg ctgccggcgg tgctgcccgt tccgccggcg ccgccggcgc cgccgccacc
1188841 gaacagcctg gcggccgatc cgccgttgcc gccgttgccg gcgttgccgg tgtccccgcc
1188901 gttgccgccg ataccgggat tgatggccag accgttgggg gtgtcgccgc cctttccgcc
1188961 ggcgccgccg gctccggcgc tgccgccgct accgccggcg ccgccgttgc ccgacagcca
1189021 gccggccgac ccgccggtgc cgccggcccc ggcgttgccg ccgacaccgc caccgccacc
1189081 gttaccacct agtgcggcgt tgagcccggt gccgccgtcg cccccggagt tgccggcgcc
1189141 gccggccccg ccgttgccat acagcagccc accgccacca ccggcgccgc cgccgccgcc
1189201 gtcgccgccg acaccacccg taccaccctt accggcggtg gccacgacat gttcgccgcc
1189261 ggcgccggcg gccgcgccgt tgccgccggc gccgccgtgc ccggcgttac ctccgtgacc
1189321 gaacagcacg gcgcctcgtc cgccgttgcc gccggcgccg gcggtgccgc cggtgccgcc
1189381 ggtgccgccg tctccaccga attggccgcc gttgccggca ccgccggcgg tgccgccgcc
1189441 gccgccgttg ccggcgtcac cgccgttgcc ggacagccag ccggccgacc cgccgtcgcc
1189501 accgcggcca ccggcgccgc ccgcaccacc ggcgccgccc ggttggctgg gtgggccggg
1189561 ggcgccggga ctggcttgtc cgccggcccc gccggcgccg ccgtcaccgc cggcgccgcc
1189621 gtggccgtgg atccagccgc cggcaccgcc cgccccgccg gcgccggcgt caccgccctt
1189681 ggtgccgctg gccccggcgc cggcaccgtt gccgccttgt ccgccgtcac cgccgacgcc
1189741 gccgacaccg ccgttgccga acaatccggc cgttcccccg gccccgccgg caccacccgc
1189801 gacgcccggc gcgccgatgg ctccggcggg gccggcgccg ccggcgccgc cattgccgcc
1189861 gctgccgtag agccagccgc cgttgccgcc cgcgccgccg ttggcgccgg ctccgccggc
1189921 ccctccgttg ccgccgttgc cgatcaaccc ggccgacccg ccggtacccc cggtgagccc
1189981 ggcggtggtt tgggaaaacc cgttgccgcc gttgccgtac aacaacccac cggcgccacc
1190041 gttgggattg gccgcggtcc catcggcgcc gttgccgatc agcggacgcc ccaacagcgc
1190101 ctgggtgggc gcgttgatca aacccagcac ctgctgctcg acattggtcg cctcggcgct
1190161 ggcatacgcg ctcgccgccc cggtcaatgc ctgcacgaac tgctcgtgaa acagcgctgc
1190221 acgcgcgccc agctgttgat actggccggc gtgggcggaa aacagtgccg cgaccgccgc
1190281 ggacacctca tcggcaccgg ccgcggccag caccgacgtc ggggccaggg cggccgcgtt
1190341 ggccgcgctg attgccgaac cgataccggc cacatcggcc gccgcggcca tcagctgcga
1190401 cggagacacc aacacaaacg acacggtttc ctctccctga tttgctgata tgtagttgcg
1190461 atgttaacta gcgcacaccg caactggggc ggttttccgc cattgtctgg tcgcacgtat
1190521 acatttttgt gaattctttg agcggaattg ctcgtgcgat ccggctacgt tttcgaggtg
1190581 agatctgggt gggcggcgat gccccgtgct tcgatgatca atttggggat ctgaaatgtc
1190641 aaatgtgttg acattcattg ggtgatcttt cgcgccaccc ggcgacgtca aatacttgga
1190701 cataagccac tcgtcgttgt gtgatacgtc gtcacaccgg atctggccgt gcgggtttat
1190761 tgcccgggcg tgccggggtt gccggagatc tgcccgcgac taccgccggc gcctccagtg
1190821 ccgttgattc cgggcatcag gccggtgccg cctttgccac cgttgccgcc gttaccgccg
1190881 ttaccgatca actgggcgtc gccgcccttg ccgccgtcgc caccgttgcc gccgttgcct
1190941 ttggcgccgc tgccggcgcc cagaccgccg ttgccgccgt cgccgccggt gccgccgctg
1191001 cctccgctgc cgagcaggcc ggcggtgccg ccgctaccgc cggcaccgcc cgcgtggccg
1191061 ttgccaccgt tgccgccggt gccgccgccg aagccgccgc caccgccggt gccgccggtg
1191121 ctgcccatcc caccggcgcc gccggcgccg ccgtcgccga acagcttggc ggccgatccg
1191181 ccgtggccgc cgttgccggc gttgccggtg tctgcgccct ggccgccgtt accgggatca
1191241 ataccgctgt tgccgttgcc gccttggccg ccggcgccgg cggtgccgcc gcctccgccg
1191301 gtgccgccgt tgcccgacag ccagccggct gacccgccgt tgccgccgtt gccggcgttg
1191361 ccgccgccgc cgccggtgcc ggcgtcgccg ccgttgccgg acagccagcc ggccgacccg
1191421 ccgtcgccac cgcggccgcc ggcgccgccc gctccgccgg caccgccggc accgccgttg
1191481 ccgaacaatc cggccgttcc cccggccccg ccggcaccac ccgcgacgcc cggcgcgccg
1191541 atggctccgg cggggccggc gccgccggcg ccgccattgc cgccgctgcc gtagagccag
1191601 ccgccgttgc cgcccgcgcc gccgttggcg ccggctccgc cggcccctcc gttgccgccg
1191661 ttgccgatca acccggccga cccgccggta cccccggtga gcccggcggt ggtttgggaa
1191721 aacccgttgc cgccgttgcc gtacaacaac ccaccggcgc caccgttggg attggccgcg
1191781 gtcccatcgg cgccgttgcc gatcagcgga cgccccaaca gcgcctgggt gggcgcgttg
1191841 atcaaaccca gcacctgctg ttcgacgttg gtcgcctcgg cgctggcata cgcgcccgca
1191901 cttgacgtca gggccagcgt gaactggtca tgaaacgctg ccatctgccg ggcgatcgcc
1191961 tgatagccct cgccatgtcc gctaaacagt gccgcaatgt gggccgacac ttcgtcggcg
1192021 gcggccggca acaacctcgt cgtcgcggcc gcggccgccc tcgttgaggc attgatcgac
1192081 gatccgatgc tggccaaatc cccagccgcc gagctgagca tgtctggcac cgcaatcatg
1192141 taggacattt cgcgcatctc cctcatcgcc gggcgacgga tatcgggacc ggagtcaacg
1192201 tgatggcgcg agtctaagca cgcccggaac ggaaatgcag agtgttcgac aaatctttcc
1192261 ccaagacatt tttattggtc gcacgatggg cgtcgtcgtc gagcggtatg gcagcaccga
1192321 tttgtcttcc aggggaatgt tcgtaccgtt tcatgacgtc gactgtgtcc aatagcttta
1192381 catttcccgt ttttatttgc tgatgatgtc taacacctag acaaacaccg tcttgtcgtc
1192441 catcgatatg ggctcgggct agccgccacg ccgacggcgc acgccaaacc ggccgacccg
1192501 ctgcccgccc tacgagccga agggcttggc gttggcgtgc agcaatggct gcagccgctc
1192561 cgtcttctgc tgtgtccagc cgggcggcga gagcaccgcg gcccagccgt cggccacggt
1192621 ggcgacgtag cggtgaccat gcccgtccgg cacatgcgta gccaccgcca tatcggccga
1192681 aacctggacg aacgtcacca ccgggatcca gcgtgtctgg ggaaggacgt cgtagccccg
1192741 ttgctcccgc agccagtccg gctcccgaaa cagcaggcgg ggagtccacc aggcgatcgg
1192801 atcagaggca tgctgcagat acaccacccg cggtctgccc cacggcgcat cagggcgttg
1192861 caggtcgcgt gcgcgggcca cgaaacgcac gttgcggccg tcgtcgtaga tgggcagcca
1192921 ctgcggtgat ccggcatcgc ggttcgcagt caaggagttc caaacggtgt tgttgaacgt
1192981 cggtccgctg aacaacgcgc cgtcggtgcg ggcgaggatg ttgttgaggt tcatgaacgg
1193041 cgcttcaccg ccgaacgatc ccaggctctc gccgaacacg accagcttcg ggcgctgcga
1193101 ctcgggcagt tgacggatca gcttgtcgac cgcctcgaac agcgcctcgc cggcgtgccg
1193161 ggcattctcc ttgtccacca ggaaagacag ccagctcggc aagaacgaat actgcatgct
1193221 cacgatcgcg gtatcgccgt tgtacatgta ctccagcgcg gaggcttccg cctcgttgat
1193281 ccaaccggtt ccggtgctcg tggccactgc cacaacggcg cggcgcaagc caccggtgcg
1193341 cgctagctcg cgcgccgcca gctccgcggt ggccatgatg ccgtccgccg agttcaaccc
1193401 cgcataggtt cggatcggct cgacggccgg ggtgccgttg aacgcggtga ggtcggcgat
1193461 ggtgggaccg ctgtggacga aaattcggcc ctgatggccc agcgactccc acgacaccag
1193521 cgatcccggg ccacccgatc gcagcggggt tttcggcggt gccgaatccg gattcatctc
1193581 attgttgacc gcagcgaacg tgctgttcat ggaattcatc gcgaacttga gcaccacacc
1193641 gttgagcagt gtgatggtca gcaccacgag cagcaccacc acaatggccg ccgaaactcg
1193701 gaatggcgca atgcgatcga cctgtcccac cagaaaacgg aacagccatc ggatgaactg
1193761 gccgatttcg accagcgtga acagcacgac cagcgacaat gcggcggcca gcgggtagtc
1193821 gtaccaccgc aggtgctcga cacccattag gtcgcgcaca tcgtcttgcc agacatgaaa
1193881 ctgcactgcc atacccacca tgccgaccgc gccgactgcg atcagcggcg gccacgccca
1193941 gcgtggtggc ggcgggctgg aattgtgcga gcgcatgtag cggaccagcc agacggcgaa
1194001 gactcccaag ccgtatccga aggcgccgca gattccgctg accagtccct gaaacagcgg
1194061 accacgcggc agcagcgacg gcgtcatcga gaaccacacg aaaacgaggc ccatcgcggt
1194121 gccggtgaat gtgtagtggc gaatccacca agtgctgcgg atcggttgcg gttcaggggt
1194181 ttgtggagtt gctgcggtgt cgaccgcctg ctcagcgccg gtagctggtt cgtcgctggc
1194241 gttggtggtc gtcgctgcag ccggttccgt catcggtggg tgaactgggg agcgcgtttc
1194301 tcgatgaacg ctgccatacc ttcggattgg tcttcggtcg cgaaagccga atggaaaagc
1194361 cggcgttcgt agagcagccc ctcggacaaa ctggattcga aagcccggtt gacggcctcc
1194421 ttggccatcc gggccgccga ggccgacatc tgcgaaatgg tcgtggcagt ggccctggct
1194481 tcggtcagca agtcgtcggc cggcaccacc cgtgaaacca gaccgctgcg ctcggcctcg
1194541 gcggcgtcca tggtgcgccc ggtcaggatg aggtccatcg ccttagcctt gccgatagcc
1194601 cgggtcagcc gctgggagcc gcccatgcct ggcagcacgc ccagctttat ctcgggctgt
1194661 ccgaacttcg cggtgtcggc ggcgatcagc acgtcgcaca tcatcgccag ctcgcagcca
1194721 ccgccgagcg cgtatcccgc caccgcggcg atcgtcgggg tgcgcacggc ggccagcttg
1194781 ccccaggtgg cgaagaagtc ggcggtgaac gcgtcggcga acgtcaggtc ggccatttct
1194841 ttgatgtcgg ctccggcggc aaacgctttg gccgaaccgg tgatgatgat cgccccaatg
1194901 tccgggtcat cgtccagttc ggttgcagcg ctggtgacct cgttcatcac ctggctgttg
1194961 agcgcgttca gtgcctgggg acggttcagc gtgataatgc caactcgctg atcgcgctcg
1195021 accaggatgg tttcgtacgt catgcgctac ctctctagaa actcaagtca tcgtcgaccg
1195081 gttcgaaata ggcttcgatg tcggccgccg tgatcgcgtc cagggttgcc ggcgaccagt
1195141 tcgggttgcg atccttgtcg atcaactgcg cgcggatgcc ctccaccagg tcatgcgagc
1195201 gcagcgacgc cgatgacacc cgatagtcct ggatcaacac gtcttctagc gtgtcgagtt
1195261 tggcggcgcg acgcactgcc tgcaacgtca ccgacagcgc gatgggggag cggctggcaa
1195321 tcaggtcgga agcatttacg gctggttcgc cgccctgttt ccgcagcgcc gcaacgatgt
1195381 cggcgacgct gtcgccggca tagcattcgt cgatccaatc acgttgggcg gcaagcgtgc
1195441 tcggtggagg ttcgacggcg tgggcggcca atgcgctctc cacgccgccg gtgacgatct
1195501 tctgcgtgaa cgcatcgagg tcgccgtgtg gcacgaagtg gtcggcgaat cccagcgcga
1195561 tggcgtcggc gccggaaaac ggcgctccag tcagggcggc gtgcagaccc agcgcgccgg
1195621 gtgcacgcga cagcaaatac accccgccga cgtcggggat gaacccgatg cccacttcgg
1195681 gcatcgcgac cttggaggta tcggtaacca cccgggtgtt cgcgtgtgcg ctgacgccga
1195741 cgccgccgcc cattacgatg ccgtccatca acgccacgta gggcttggcg aaccggccga
1195801 tcagggcgtt gagcagatac tcgtggcgcc agaaccgccg cgcctcgacc ccgtccttgc
1195861 gggcactgtg gtagacggcc accacgtccc cgccggcgca aagtccgcgt tcgccggctc
1195921 cggagagcac caccgcgtgc accgcgtcct catgctccca gctcatgagc actgtggcca
1195981 gcaggtcgac catggtttgg ttcagtgagt tgatcgcctt ggggcggttg agcgtcacga
1196041 atccgacacc gccctcgacg tttgtcagga cctcatgcga ttcgccggtc acgggcctcg
1196101 cctcccctga agagtttgac cagcaatcta gatcgtggct cgcccagcgg tgcccgcggg
1196161 ggctaaggtt tatcgtgtac ccggatgaca acgctggccg ggaacccggg cctactactg
1196221 atcgttgagc ggatgttcgc acagctcgta gccatagcca tcaagagagg atccgacggt
1196281 gcgggagaca agcaacccgg tatttcgttc gttgcctaag cagcggggcg gatacgcgca
1196341 attcggaact ggcaccgccc agcagggatt cccagccgat ccctacctgg cgccctatcg
1196401 ggaagcaaag gccacccgcc cgctgaccat cgacgatgtc gtgaccaaga cgggcctgac
1196461 gctggctatg ttggcgggca ccgccgtcgt ctcctacttc ctggttgcgt cgaacgtcgc
1196521 actggccatg ccgctgacct tggtgggggc tttgggtggt ttggcgctgg tgctggtggc
1196581 caccttcggc cgcaagcagg acaacccggc gatcgtgctc agctacgcgg cgctcgaggg
1196641 cctgttcctg ggtgccatct cgttcgtctt ggctaacttc acggtggcgt ccgcgaatgc
1196701 tggggtgctg atcggggagg ccatcttagg gacgatgggt gtgttcttcg gcatgctcgt
1196761 cgtctacaag acaggggcca tccgggtcac ccccaagttc acccgaatgg tggtcgctgc
1196821 gctgttcggc gtgctggtct tgatgctcgg caacctcgtg ctggcgatgt tcaatgtcgg
1196881 cggcggtgaa ggcttgggct tacgcagccc cggaccgctg gggatcatct tctcgctggt
1196941 gtgcatcggc atcgcggcgt tcagcttcct gatcgacttc gatgcggctg atcagatgat
1197001 tcgcgcggga gcaccggaga aggcggcatg gggcgtcgcg ttaggcctga ccgtaacgct
1197061 ggtctggttg tacatcgaga tcctgcgcct gctcagttat ctacagaatg agtagcgctc
1197121 gttggccgtt gattctgcgt ccaccaggct gaccactcgc acttttgcgt ggtagacgca
1197181 ggatcaacgg ctgtgtcggt gggtgctgac accatgcccg catgcgggag atgggggcgc
1197241 agccgttcat cggcagcgag gcgttggcgg cgggactcat cagctggcat gagctgggca
1197301 agtactacac cgcgatcatg cccaacgtct atctggacaa gcggctgaag ccctccctgc
1197361 ggcaacgcgt tatcgcggcc tggctgtggt cgggccgcaa aggggtgatc gccggcgctt
1197421 cggcatcagc gctgcacggc gcgaaatggg tcgatgacca cgcattggtg gagttgatct
1197481 ggcgcaacgc cagggcgccg aacggggtgc ggactaagga tgagctactg ctcgacggcg
1197541 aagtccagcg cttgtgcggg cttactgtga ctaccgttga acgtacggcc ttcgacttgg
1197601 gcaggcgtcc acccttaggt caggcgataa ccagactgga tgcgcttgcc aatgccaccg
1197661 atttcaagat caacgatgtt agggagctcg cgaggaagca cccccatact cgcgggctgc
1197721 gtcaactaga caaggcgctg gatctcgtcg acccaggtgc gcagtcgccg aaggagacgt
1197781 ggctgcggct cttgctgata aacgccggct ttccacggcc gtccactcag atccccttgc
1197841 tcggcgtcta cgggcatcca aagtatttcc tcgacatggg atgggaggac atcatgctcg
1197901 cggtcgagta cgacggcgag caacaccgtc tcagccgaga ccagttcgtc aaagacgtcg
1197961 aacgcctgga atacatccgg cgcgccggct ggactcacat cagggtgctg gcagaccaca
1198021 agggacccga cgtcgtccgc cgggttcggc aggcttggga cacgttgaca tcacgacgtt
1198081 gactctgcgc ccaccacgtg tcctactcgc acttttgcgt ggtggacgca gagtcaacgc
1198141 actcgagcgc ctcgctcacg cgaggcgctc gatcaccatc gccatgccct ggccgccacc
1198201 gacacacatg gtttccagac cgaacgtctt gtcgtaggtc tgcaggttgt tcaacagcgt
1198261 ggtggtgatg cgcgcgcccg tcataccgaa cgggtgacct agggcgatcg cgccacctga
1198321 gatgttgagc ttgtcctcgt cgatgcccag ctcgcgcgcc gagcccagga cctgcaccgc
1198381 gaaggcctcg ttgatctcga ccaggtcgat gtcggtgatc gccatcccgg ctctttccag
1198441 cgccttcttg gacgcctcga tcggccctaa gcccatgatc tccggggaca gcccgctgac
1198501 cccggtggac acaatgcgcg ccagcggtgt caagcctaat tccttggcct tggtgtcgct
1198561 ggtgatcacc accgcggcgg ccccgtcgtt gagcggacag gcattccccg cggtcacggt
1198621 gccattcggc cggaaagccg gcttgagctc gctgaccttt tcgtaggtgg tacccggtcg
1198681 cgggccgtcg tcggtgctga ccgtggtgcc gtccggaagg gtgaccggcg tgatttctcg
1198741 ttcgaagaac ccgttcttga tcgcctcttc ggcccggttc tggctgcgca cgccccagcg
1198801 gtcctgttct tcgcggctga tgccggtcat gatggcgacg ttttccgcgg tctggcccat
1198861 cgcaatatag atgtccggca gcttctgatc ggtgcgggga tcgtgccatt cgtcggcgcc
1198921 ggcggctgcc gcggccgaac gttcctgagc cccgtcgaac agcgggttct tggtgtccgg
1198981 ccaggagtcg gagtttccct tggcgaaccg ggagacggtt tccacgcccg cggagatgaa
1199041 cgcgtcgccc tcaccggcct tgatcgcgtg gaaggccatc cgggtggtct gcagcgacga
1199101 cgaacagtac cggttgaccg tggtgcccgg caggaagtca tagccgagcg cgacggcgac
1199161 gacacgggcg atgttgaaac cggactcacc gcctggcagg ccacagccca tcatgaggtc
1199221 gtcgatctga tgggggttca gtgccggaac cttgtcgagc gcggcgcgca ccatctggac
1199281 ggccaggtcg tcgggccgca tgccgaccag cgatcctttc atggcccggc caatcggcga
1199341 gcgggcagtc gagacgatga cagcttctgg catgacggct cccggcatgg acaagacgtg
1199401 gtgaagttta ggtcaaatgt agtcgctacc caccggtcgg cacggcccgg gccggccggg
1199461 gccgccgcag ccgcgacatc atgctgtgtc gcgtgtggcc cggctcgagg gtggccgttc
1199521 caggccggga cggcgtttca tgaattggga tatcgagctt ttcggtcagc gcatcgcgca
1199581 gcgcaaggaa caacagatcg gccgccaggg cgtacgcggg cgccgacggg tggtagcggt
1199641 cggcggagaa catcagctcg ggcattgccc ggaatttggg agccagtaga tgtcctagcg
1199701 gcaccggcac cccaccggcc gccttgacgg ctgccgtttg ggcgcgggcc agccgcacac
1199761 cacgggtgtg cgctagcgcg cgcagcggct gcgggatggc ggtaatgacg ccgaggtcgg
1199821 ggcaagtgcc gaccaccact accgctccgc gggtgcgcaa cctgcgtacg cagtcggcca
1199881 gccgttgcgc agaggggcca atgccgttga gtgccgttat gtcgttggcg ccaatcatga
1199941 ttaccgccgc atccggcggc ggaccgacca cgaacatcgc atcgacttga ccgcagacgc
1200001 ctttcgaggt ggcgccgacg atggctttgg tgctcagccg gatccgcttg ccggtctgct
1200061 cggcgagtcc gcgggcgatc aacacgcccg gtacttcctc agcgctagcg cagccgtatc
1200121 ccgtcgccgt cgagtcacca aagatcatca ggtgcacgtc gaagggcact tcgcgtcgcc
1200181 accgttgcac gggcccaccg ccgcgggtgt atacgccgtc ggcgcggggc ggtgcgtcga
1200241 aggatttggg aattaccgtg cgcgcgtggg tcgcctgacc gaccagcagg ttgcgtgcgc
1200301 ccagataggc cgtgcccgtc gaggcgagtg cacccgcggt ggccaaagcg atcgtggaac
1200361 gccgtggcac gcgcatgctc acgggatcag tttaggacgg ttgtgccgat ttcgtggata
1200421 gctgacgaac aaacccgtca cggtgtggac caaatgtggt atcgaatcag actctttggc
1200481 tgtggcacct aaaaaagact gtcaagctaa gttcgcgggg ttggctgagc cagaggctca
1200541 gccgcttcgt cacatgctgt atcggactac aacggcgtag gaagtgttgg gcatgactgc
1200601 acccagtaag gtatccggct cacccagagt tgtcatttcg ccgcgcgacg tgttgaaggc
1200661 acgtagactc gaggcacgca agtttgcgat cagcgacggc gccccggtgg aggtcgtcga
1200721 gtctggtcca agtcttgttg cgcgattagc tgcgctggcg tcacgagtgg cggtccggcc
1200781 ggtgctagcg gtcggtagct atcttccgca tgcgccctgg ccgtggggtg tcatcgacca
1200841 ggctgcccgg gttctgctcc cagcgtcaac gaccgtaagg gccgcggtga gcctgcctaa
1200901 tgcgtccgcc caactggttc gggcgtcggg tgtgttgccg gcggacggca ctcgacgcgc
1200961 cgtcctgtac ctgcacggcg gcgcgtttct gacgtgtgga gcaaactcgc atggacgact
1201021 cgtcgagttg ctctctaagt tcgctgactc gcctgttctg gtggtcgact atcggttgat
1201081 tcccaagcac tcgatcggga tggcgctcga cgactgtcac gacggctacc ggtggctgag
1201141 gctgttgggc tatgagccgg agcagatcgt gctagcgggc gattccgcgg gcgggtatct
1201201 tgcgctcgct ctcgcgcagc ggctacagga agtgggggag gagccggcgg ctctagtcgc
1201261 gatctcgcca ctgctgcagc tagcaaagga acacaagcag gcgcatccca acatcaaaac
1201321 cgatgcgatg ttcccggcaa gggcgttcga tgcgcttgac gcattggttg ctagcgcagc
1201381 agcgaggaac caggtagacg gcgaacccga agagctctat gagcccttgg agcacatcac
1201441 accggggctg ccgcggacac tgattcacgt gtcgggctcc gaggtattgc tgcacgacgc
1201501 tcagttggcg gcggccaaac tggcggcggc cggggtgccg gccgaggtcc gggtatggcc
1201561 gggccaggtc cacgactttc aggttgcggc gtcgatgctg cccgaggcga tccgctcgtt
1201621 gcgtcagatc ggggagtaca tccgcgaggc caccgggtag cgggatgccg acggagcgcg
1201681 tgtgcctggc cggcaggcgc ctgagacgat gaacgcatgc ggatcgcgca acatatcagt
1201741 gaactcattg gtggtacccc actggttcgg ctgaactccg tggtacccga cggcgccgga
1201801 accgtggccg caaaggtcga gtatctcaac cctggcggca gctccaagga tcggatcgcg
1201861 gtgaagatga tcgaagccgc cgaggccagc ggtcagctga agccgggtgg caccatcgtc
1201921 gaacccacgt ccggcaatac cggcgttggt ctggcgttgg tcgctcagcg ccgcggctac
1201981 aagtgcgtgt tcgtctgccc ggacaaggtc agtgaggata aacgcaatgt gttgatcgcc
1202041 tacggcgccg aggtcgtggt gtgcccgacg gcggtcccgc cgcacgatcc ggccagctac
1202101 tacagtgtgt cggaccggtt ggtccgtgat atcgacggtg cctggaagcc cgaccagtac
1202161 gccaacccgg agggaccggc aagccattat gtgaccaccg gcccggaaat ctgggccgat
1202221 accgagggca aggtcaccca tttcgtggct ggcatcggca ccggcggtac catcaccggc
1202281 gctggccggt acctcaaaga ggtgtccggg ggccgagtac gcatcgtcgg cgccgacccg
1202341 gagggatcgg tctattcggg cggtgccggc cgaccgtatc tggtcgaggg ggtcggcgag
1202401 gatttctggc cggcggccta tgacccgagc gtgcccgacg agatcatcgc ggtgtccgac
1202461 tccgactcgt tcgacatgac caggcggctg gcccgcgaag aggcgatgtt ggtcggcggg
1202521 tcgtgcggga tggcggtggt tgccgcgctc aaggtcgccg aggaagccgg gcccgacgcg
1202581 ttgatcgtcg tcctgttgcc cgacggcggc cggggctaca tgtcgaaaat cttcaacgac
1202641 gcgtggatgt cgtcctatgg gttcctgcgc agccgccttg acgggtcgac cgagcaatcc
1202701 accgtcggtg atgtgttgcg ccgcaagtcc ggcgcgctgc ccgccctggt gcacacccat
1202761 ccgtcggaga ccgtgcgcga cgccatcggg attcttcgcg agtacggggt gtcgcagatg
1202821 ccggtggtcg gcgccgagcc gccggtgatg gccggcgagg tcgccggtag cgtctcggaa
1202881 cgcgagctgc tctcggccgt gttcgagggc cgcgccaagt tggccgacgc cgtgtcggca
1202941 cacatgagcc cgccgctgcg gatgataggc gccggtgaat tggtcagtgc ggccggcaag
1203001 gcgttgcgtg attgggatgc gttgatggtg gtggaggaag gcaagccggt tggggtcatt
1203061 acccggtacg acttgttggg cttcttgtcg gagggggcgg gacggcggta gtcgcgcagg
1203121 caggcgcgcc gcaatttagt tcggctacaa acaattacgg caggcggcca gtgccgcaca
1203181 ggtcgtgggc actgacccat tgggccccgt ggctcatctc accgccgggc gttccggtga
1203241 atccggtcct caggtactgt agtcccgcct agttcaccct agttcagctg aacctcagtg
1203301 gaaggtgtgc ccatgaccga acagccgccc cccggcgggt cgtacccacc gcccccgcca
1203361 ccgcctgggc cgtccggtgg gcatgagcca cctcccgctg caccacccgg cggcagtggt
1203421 tacgctccgc cccctccgcc ctcgagcggc agtggctacc cgcctccgcc gccaccgcct
1203481 ggcggggggg cctacccgcc gcctccgccg tcggccggcg gttacgcgcc gccgccgccc
1203541 ggaccggcga ttcgtacgat gccgaccgag tcctacacgc cgtggattac ccgggtgctg
1203601 gcggcattca tcgactgggc cccatacgta gtgctggttg gcatcggttg ggtgatcatg
1203661 ctggtcactc agacgtcgtc gtgcgtcacc agcattagtg agtacgacgt cggccagttc
1203721 tgcgtttccc agccgtcgat gatcggccag ttggtgcagt ggttgttgtc ggtgggcgga
1203781 ttggcttacc tggtctggaa ctacggctat cgccagggca ccatcgggtc gagcatcggc
1203841 aagtcggtgc tgaagttcaa ggtggtcagc gagaccaccg ggcaaccaat cggcttcggg
1203901 atgtcggtgg tacgccagct tgcccacttt atcgacgcga tcatctgctt cgtcgggttc
1203961 ctgtttccgc tgtgggacgc taaacggcaa acgttggcgg acaagatcat gacgacggtg
1204021 tgcgtgccga tctgatccgg gactgcactg cccacccgac cgtccgatga gcgaagaccg
1204081 cacgggacac cagggaatca gcggaccggc cacccgcgcc atccacgctg gctaccgccc
1204141 ggatccggcg accggggcgg tgaacgtgcc gatctacgcc agcagcacct tcgcccaaga
1204201 cggcgtcggc ggtctgcgtg gcggtttcga atacgcacgc accggcaacc ccacccgggc
1204261 cgcattggag gcctcgctgg cggcagtcga ggagggtgct ttcgcgcggg cattcagttc
1204321 cgggatggcc gcgaccgact gcgccctgcg ggcgatgtta cggcccggag accacgtcgt
1204381 cattcccgat gacgcctacg gcggcacatt ccggttgata gacaaggtgt tcacccggtg
1204441 ggatgtccag tacacgccgg tgcggcttgc cgatctggat gcggtgggtg ccgcgattac
1204501 tccgcgcacc cggctgattt gggtggagac gcccaccaat ccgctactgt cgatcgccga
1204561 tatcacggcc attgccgagc tgggcacaga cagatcggca aaagtattgg tggacaatac
1204621 ctttgcctca cccgcgttgc agcagccgtt gcggctgggc gccgatgtgg tgttgcactc
1204681 gactaccaag tacatcggcg gccattccga cgtggtggga ggtgcgctgg tcaccaacga
1204741 cgaagagctg gacgaggagt tcgctttctt gcagaacggc gccggcgcgg tgcccggacc
1204801 attcgacgcc tacctgacca tgcgcggcct gaagaccttg gtgctgcgga tgcagcggca
1204861 cagtgaaaat gcctgtgcgg tagcggaatt cctcgctgat catccgtcgg tgagttctgt
1204921 gttgtatccg ggtttgccca gtcatcccgg gcatgagatt gccgcgcgac agatgcgcgg
1204981 cttcggcggc atggtttcgg tgcggatgcg ggccggtcgg cgtgcggcgc aggacctgtg
1205041 tgccaagacc cgcgtcttca tcctggccga gtcgctgggt ggggtggagt cgctgatcga
1205101 acatcccagc gccatgaccc atgcgtcgac ggccggttcg caattggagg tgcccgacga
1205161 tctggtgcgg ctttcggtcg gtatcgaaga cattgccgac ctgctcggcg atctcgaaca
1205221 ggccctgggt taactaccgc gagcagacgc gaaagcaccc caaaaccgcc ggtttggggg
1205281 cttctgcgtc tgctcgcggg tacctaggag tggtacggct cggcgctgac tagggtcacc
1205341 gacacggtgc tgccgttggg caccgtgtag ctgcgggtct cgccgacctt ggcgtcgatc
1205401 agggccccac cgagcggtga attcggcgag tagacctcga gcttgccgtc gctgacgccc
1205461 tcctggcggg tggcgatgag gaacgtttcg ctgtccgact tgtcgccgtt gtagtacacc
1205521 ttgaccacag aaccgggtaa tgcgacgccg gattgcttgg gtgcctcgcc aacctttgcg
1205581 ttgctgagca agtcctgcag ctggcgaatg cgggcctcct gctggccctg ctcctcgcgg
1205641 gcggcgtggt atccgccgtt ctcgcgcagg tcgccttctt cgcggcggtc gttgatttcg
1205701 gcggcgatga ccgggcgatt cgcaatcagc tggtcgagct ctgctttgag tcggtcatgt
1205761 gactcttggg tcaaccaggt gacttgagta tccgtcatct cgtcgcgctc ctcgtgttgt
1205821 cgttcccgcg tagtcgggca agtttcggat ccctgccagc agcactgtcg ggaatatttg
1205881 gggtctcacc ccgggttgcc gccgctccgt tctgcgtacg gccgttaatg cagcaataca
1205941 cggccccggc aggaccgtgc atcgatccat gctaccacca cggtcagggg aggcgcaggt
1206001 agctgggcac ttcggtgcca caaccgtata cgtccgccat caccggcggc tgggaggatt
1206061 tcacggtcgt cgtcacctgc acggtggttg cctcggacgg tgggactagc agctcacgtc
1206121 tgccggtctc gctgccgttt gttgcccgaa ctcgcacgat gcaggccacc ggtcgggacg
1206181 ggtccgaacg tgtcacgctg atggtgaccg atgccgtctc gtcgtcgacc agtcgatagc
1206241 ccaccagcga accggtgacg gcgctggtgc tgatccgttg gtagccgatg acggcaatga
1206301 cgatgccggc cgcggcgacc agcaccccca gggcgatcgc gacacggcgc cgcgctcggc
1206361 gggacagtcg cgggcgtccg tagcgggcgt ctggtcgcgg aatgggggtg tgggtcatgc
1206421 ctgggttcac gccggcggga tgcaacgctt cgacaaaccg gaattatagg gtcacttata
1206481 ggcttaaggg ggcagccagg cggacggaca agggggcacg tgagcgaact gcggttgatg
1206541 gcggtgcacg cccaccccga tgacgagtcc agcaagggcg cggccaccct ggcgcgctac
1206601 gccgacgagg gtcatcgcgt gctggtggtg acgttgaccg gtggtgagcg cggcgagatc
1206661 ctcaacccgg cgatggacct gccggacgtg catgggcgca tcgccgagat ccggcgtgac
1206721 gagatgacca aggcggccga gatcctcggt gtcgagcaca cctggctggg cttcgtcgac
1206781 tccgggctac ctaagggtga tttaccgcca ccgctgcctg atgactgctt cgcgcgggta
1206841 ccgctggagg tgtccaccga ggcgctggtg cgggtggttc gcgagtttcg gccgcacgtg
1206901 atgaccacct acgacgagaa cggcggctac ccacatcccg accacattcg ctgccatcag
1206961 gtttcggtgg ctgcctacga ggcggccggt gacttttgcc ggtttcccga cgcgggtgag
1207021 ccgtggacgg tgtccaagct gtactacgtc cacggcttcc tgcgggagcg gatgcagatg
1207081 ttgcaggatg agttcgcccg gcacggccaa cgcggcccat tcgaacaatg gctggcgtac
1207141 tgggaccccg accatgactt tctcaccagc cgagtgacca cccgggtcga gtgctcgaaa
1207201 tacttcagcc aacgcgacga tgcgttgcgc gcgcatgcca cccagatcga cccgaacgcc
1207261 gaattcttcg ccgccccgct tgcctggcag gagcggctgt ggccgaccga ggaattcgag
1207321 ttggctcgct cgcgtatccc cgcgcgccca ccggagaccg aattgttcgc cgggatcgag
1207381 ccgtgaacca gattctgctc agcgtgattg ctgagggcgg gcccggtaac accggacccg
1207441 atttcgggaa ggctagcccg gtggggttgc tggtgatcgt gctattggtg atcgccacgt
1207501 tgtttctggt gcgttcgatg aaccagcaac tgaagaaagt tcccaagtcg ttcgaccggg
1207561 atcaccccga gctcgaccag gcagccgacg agggcaccga ccgcgacgga ccggcccgac
1207621 caccgggacc cccgcatgag tccggctaat ccgtccggga cgaataccct cgcgctggcc
1207681 accagcccgt acctgcgcca gcacgctgat aacccggtgc actggcagca gtggacgccg
1207741 caggcactgg cggaggcggc cgcgcgcgcg gtgccgatcc tgctgtccgt cggctacgcc
1207801 gcctgccact ggtgtcacgt catggcccac gagtcattcg acgacgacga ggtggccgcg
1207861 gccatgaacg cgggcttcgt ctgtatcaag gtcgaccggg aggagcggcc cgacatcgac
1207921 gcggtctaca tgaacgccac cgtcgcgctc accgggcagg gcggctggcc gatgacatgc
1207981 tttctcaccc ccaacggccg gccgttcttc tgcggcacct actacccgaa agcggctttc
1208041 ctgcaacttc tttcggccat atccgaaacc tggcgggaac gccgcgctga ggtggagcag
1208101 gcatctgacc atatcgctgc cgagttgcgc tcgatggctt cggggctgcc cgggggtggc
1208161 ccggaggtgg cgccggagct gtgtgacgac gcggtggcag gagtgctgcg tgagcaggac
1208221 acggcgcacg gcggatttgg cggtgcgccg aaattcccgc cgtcggcact gctggaagcg
1208281 ctaatgcggc actacgagcg cacccgatca ccggcggcgc tggaggcggt cgcacgcact
1208341 ggaaacgcca tggcccgtgg cggcatctat gaccaactcg gcggcggttt cgcccgatac
1208401 agcgtcgacg gtgcctgggt ggtaccgcat ttcgagaaga tgctgtacga caacgcgctg
1208461 ctgctgcgcg cctacgcgca ctgggcccgc cgtaccgggg atccgttggc ccgccgggtc
1208521 gccgcccaga ccgcgcgatt tctgctcgac gagttgggca gcaaagcacc ggccgacatg
1208581 ttcacctcgt cgctggatgc cgacgccgac ggccgcgagg gttcgaccta cgtttggacg
1208641 ccggtgcaac tgaccgaggt gctcggcggc gacgacggcc gttgggcggc agaggttttc
1208701 ggggtgaccg aggccggcac cttcgagcac gggacgtctg tgctgcagtt gcccgccgac
1208761 cccgacgacg cggcgcgtct ggaccgggtc cgcgccgcgt tgctggtggc ccgcctggcc
1208821 cgggcccagc ccgcccgcga cgacaaggtc gtcacgtcct ggaacgggtt ggcgatcacc
1208881 gcgctggccg aagccagcgt ggccctggac gaccccgcgt tggcgcacgc cgcgcggcgc
1208941 tgcgcgacca ggctgctgga cctgcacgtc gtcgacggcc gcctgcgccg ggccagcctg
1209001 ggcggggtgg tcggcgacag cgccgccatc ctggaggacc acgcgatgct ggccaccggg
1209061 ctgctggcgc tctaccagct gacctccgag ggcgcgtggc tgacggcggc taccggattg
1209121 ctggacaccg cggtggcgca tttcggcgac ccgcagcgcc ccggtcgctg gttcgacacc
1209181 gccgacgacg ccgagcggct gatgctgcgg ccctccgatc cgctggacgg ggcgacaccg
1209241 tcgggcgctt cgtcgatcgc cgaggcgctg ctgacggcgg gccatgtggt cgacggtgct
1209301 cgcgccgagc ggtattggca gctggcggcc gacacgctgc gggcgcatgc ggtgctgctg
1209361 gctcgggcgc cgcggtcggc cgggcattgg ctggcggtcg ccgaggcggt ggtgcgcgga
1209421 ccgctgcaga tcgccgtcgc gtgcgacctg ccgcggtcgt ccctgctggc cgacgcgcgc
1209481 cggctggccc cgggcggggc gatcgtcgtg ggcggcgcgg cgggttcgtc ggcgctgctg
1209541 gtcggccggg atcgggtggc cggcgccgac gccgcctacg tatgccgggg ccgggtctgc
1209601 gatctgccgg tgaccagcgc ggccgaactc gccaccgctt tgggcgtacc cggctagcgg
1209661 actcgggtgg cacccgtcca ccgtgaaatc cgcgacgcgg tgtcggcgtg tcgcgtcgca
1209721 attttcacgc tcgcgaccgc cctgggcgtg ccgggtcaga acaccacgaa ccacatcgcg
1209781 atgtagtggc agatcgccgc caccgcggtg caggcgtgga agaactcgtg gtagccgaac
1209841 gtcgtcggcc acgggtcggg ccagcgtacc gcgtagagaa tgccgccgat gctgtacaac
1209901 gcgccgccaa caaacagcaa caccaacgcg gtcaccccgg cgttgtgcag gatcgtcgcg
1209961 gtgtaccaga ccgccaccca acccagcaac aggtacagcg gaaccccgac cgagcgcggc
1210021 gccgccggcc aacacatctt cagcaagatt ccggcgatcg caccgcccca aacaatcgac
1210081 aacaccacgc gcccgtcgtg ggccggcaag gccagcagcg cgaacggcgt gtagctgccg
1210141 gcgatgaaca cgaagatcat cgagtggtcg gcccgcttca tccagttgcg ggccgtcgcg
1210201 gatttccaat tgacccggtg ataagtggcg ctgacggtga acatggtgat cgtggccgcg
1210261 gtgtaggcca gcgtcgtcag gcccgccttg gcggaaccca ccgcccacga caccgcgacc
1210321 agcgacgcac cggccaacac cgcggtgccg gcggaataca cgtggatcca gccgcggaag
1210381 cgcggtttgg tcaggacacg ggcgacacct tcgacgaggt ggtgggcagc gtgggccggc
1210441 gtccttgctt ccgcggtggt ggcggtgtcg gcctggccgc tcatttcgcc tgttgcctcg
1210501 tcttgtgctt gccggtgggt gtcgtcgaac acagtagtcg ggccaggtag cggacatctg
1210561 actcgacgtc tgggtcacag tagtctgggt atctgtggag atcatcccgc cgcggctcaa
1210621 agagccgttg taccggctct acgagctgcg cctgcggcag ggcttggccg cctcgaaatc
1210681 cgacctgccc cggcacatag ccgtgctgtg cgacggcaac cggcgatggg cgcgcagcgc
1210741 gggctacgac gacgtcagct acggctaccg gatgggtgcg gccaagatcg ccgaaatgct
1210801 gcggtggtgc cacgaagccg gcatcgaact ggccaccgtc tatctgctgt ccaccgaaaa
1210861 cctgcagcgc gatcccgacg agcttgcagc actcatcgag atcatcaccg atgtcgtgga
1210921 agagatctgc gcaccggcca accactggag tgtgcggacg gtcggggatc tggggttgat
1210981 cggcgaggaa ccggcccggc ggctgcgcgg tgcggtggaa tccaccccgg aggtggcctc
1211041 gtttcatgtc aacgttgctg ttggctacgg cgggcgccgc gagatcgtcg acgctgtgcg
1211101 cgcgttgttg agcaaggaac tcgccaacgg ggccaccgcg gaggaactcg tcgacgcggt
1211161 gaccgtcgag ggtatctcgg aaaacctgta cacctcaggc caacccgacc ccgatttggt
1211221 gatacgcacc tccggcgagc aacgcttgtc cgggttcttg ctgtggcaaa gcgcctactc
1211281 ggagatgtgg ttcaccgagg cgcactggcc ggcgtttcgc cacgtcgatt ttctacgcgc
1211341 gctgcgtgac tacagtgcga ggcatcgcag ctacggcagg tgaatccggc gcaggacgcc
1211401 tatgttgcgc tgttcggctg cctgcgcaga gtgcacatta gccggctcgt catgctgtgc
1211461 aatctgccca ggtgaaaccc ggtgtttggg atcctggata gcgataccat cgactgatcc
1211521 atgcgggaca tccgatgctg gactgatcgg agtaaggcga tgtcgtttgt agtcgtggcg
1211581 ccggaggtgt tggcggcggc cgcttcggat ctagcgggca tcgggtcgac actggcgcag
1211641 gccaacgccg cggcgttggc gccgaccacc gcggtgttgg ccgcgggtgc tgatgaggtt
1211701 tccgcggcaa tcgcgtcgct gtttggggcg catggtcagg cgtatcaggc ggtgagcgcc
1211761 caaatgtcgg cgtttcacgc ccagttcatg caggcgttga cgggtgccgg cggggcttat
1211821 gcggctgcgg aggcggtcaa cgtctcggcg gcgcagagcg tggaacaaga cctgttggcc
1211881 gcgatcaacg ctcgcttcga gcggattttt gggcgcccgc tgatcggtga tggcgccaac
1211941 ggcgggccgg gacaagacgg cgggcccggc gggttgctgt acggcaacgg tggcaacggc
1212001 ggcaccagca cgaccgtggg gatggccggc ggcaacggtg gtgccgccgg gctgatcggc
1212061 aacggtgggt tcgggggcgg cggcgggccc ggcgcggccg gcggcaacgg cggcgccggc
1212121 gggtggctat tcggcaacgg cggcgccggc ggtgccggcg gcctcggcgt agcgcccggc
1212181 gtgcccggcg gcgccggcgg tgccggcggc gccggcggtg tcggcggacc cgccgggttg
1212241 tggggccacg ggggtgccgg cggggcgggt ggtgccggcg tggctggcgc cggcggcttc
1212301 gaggggacga tcggtgccgg cggtgccggc ggtgtcggcg gtgccggcgg tgtcggcggt
1212361 gccggcggtg ccggcgggtg gctgtacggc gacgccggtg ccggtgggga tggtggtgtc
1212421 ggcggtgccg gcggcaccgg cgggttaggc aaccgtggcg gcgccggtgg cgccgggggc
1212481 gccggtggtg tcggcggcgc cgggggtgcc gccgggctgt ggggcggcgg tggtgccggc
1212541 ggggtgggtg ggaccggcgg cggcgccggc ctcggtgctc agagcgtcac cttcagtagt
1212601 agcttaagtg gcctttccgg tggcgacggc ggcgccggcg gggccggtgg cgccggtggc
1212661 gccggtggca ccggtgggtg gctgtatggc ggcggtggtg ccgccggatc cggcggggac
1212721 ggtggtaccg gcggtcaggg cggcgccggc ggcgccggtg tatttagcct attcggatcc
1212781 ggtggcggcc ccggcggcaa cggcggcgtc ggcggcgtcg gcggtgtcgg cggtgctggc
1212841 gggcgtgccg gcttgttcgg cgtcgggggc ctcggcggcg cgggtggcga cgccggtgac
1212901 tccggcgaag gcggcttcgg cgggccgggg ctcgccggcg ggctgttcgg caaccccggc
1212961 aacggcggcg tcggcgggat cggcggcgac gccgcagccg gcggcgccgg tggggccgga
1213021 ggcaacggtg gggccggagg caacggtggg tggttgttcg gcaatggtgg tgccggcggc
1213081 tccggtggcg acggcggcgc cgccggccgt ggcggtgccg gcaacttggg ctcggccggg
1213141 ggtatcaacg cccccgccgg taaccccggc agcggctcgg tcggcatcgg cggtgccggt
1213201 ggtgccggcg gcaccgccgg gctgttcggc gacggtgggg ctggtggggc cggtggtgcc
1213261 ggcgccgccg gcggcttcgg cggcatcagc gccgccaccc cctcggcggg cagtgagggc
1213321 gccatgggtg gggccggtgg tgttggcggc aacgccaggc tgttgggcac tggtggcgcc
1213381 ggtggagtcg gcggcggcgg cggggccggc ggcgacggag gccgcggcgg agtcgcaacc
1213441 cccggcggtc agggcggtga cgctggggac ggtggcgccg gcggggccgg cggcaatggc
1213501 ggcggcgcca gcggcgccgg cgggtggctg ttggggaccg gtggtgccgg tggtgccggt
1213561 ggtaacggcg gcaatggcgg aaaagccggt tttagccctg ggccgaccaa cttcggtctc
1213621 aacggcgccg gtggtggtgg tggtgtcggc ggcaacggcg ccaccggacc ctggctgttc
1213681 ggcgacggcg gccccacccc aggcagcacc ggtgccggtg cggccggtgg tcacggcggc
1213741 gacgcccagc tgatcggcaa cggcggccac ggcggggccg gcggcaccgg ggtgccgaac
1213801 gggtcaggtg gtgccggcgg cctcagcggg ctgctgttcg gcgagccggg ggcgaacggg
1213861 taggttcggc gccgctgccg tgatcgcggc gaggcgtcgg tgtccgcgtc cgtgcgggcg
1213921 aatccagtcc ggtctgagtg cgtctactac agcttgcgca gccgtagccg cttgatggca
1213981 tcggactggt taccgtctgc ctgctgtcca cagaaaacct gtgtgcgatc ccgacgagct
1214041 tgccgtgcgt gggctacggc gaccgtcgcg aattcgtcga cgcggtggcc gtagaagcca
1214101 tctgcgaaaa cctgaatacc tcggggcaac ccgatcccga cctggtgatc cgcacctcgg
1214161 gggaacaacg cttgtccggc caccgagggc ccactggcgg agtttcgcga cgtcgacttc
1214221 tgcgcgcgct gcgtgactac agtacgccac acgcgtcgat cccctacgtt ccgccgccct
1214281 atcgaagcga cgggatccac gcttcccggc tggcggttga atcggttttc gatgcattgg
1214341 ctgggcgcgt cgaactctaa agactttatg gaaattagtt gtacagtgat aaaaccgtta
1214401 tagggtccgt tgtcaaacaa tgataatcac gtgataggaa cgtgattcat cggtctgaag
1214461 tgcttatgat gatttatata taaaaccgtt atatgtgggt aaaggattgc ggatgtcata
1214521 catgattgcc acaccagcgg cgttgacggc ggcggcaacg gatatcgacg ggattggctc
1214581 ggcggttagc gttgcgaacg ccgcggcggt cgccgcgaca accggagtgc tggccgccgg
1214641 tggcgatgaa gtgttggcgg ccatcgctag gctgttcaac gcaaacgccg aggaatatca
1214701 cgccctcagc gcgcaggtgg cggcgtttca aaccctgttt gtgcgcacct tgactggggg
1214761 gtgcggagtc tttcgccggc gccgaggccg ccaatgcgtc acagctgcag agcatcgcgc
1214821 ggcaggtgcg gggcgccgtc aacgccgtcg ccggtcaggt gacgggcaat ggcggctccg
1214881 gcaacagcgg cacttcggct gcggcggcca acccgaattc cgacaacaca gcgagcatcg
1214941 ccgatagggg cacaagcgcc atcatgacca cggcaagcgc gaccgcgtct tccacgggcg
1215001 tcgatggcgg aatagcggcg acgtatgcgg tcgcctcgca atgggatggt ggctacgtgg
1215061 ccaattacac gatcacccaa ttcgggcgcg acttcgatga ccgattggcg gttgcaattc
1215121 actttgcctg aaaatgcctc tatttcgaac gcgtgctgcg ctcaacttgc ccagtcgggc
1215181 acgcagtaca ctcttgacgc ccgagagcta taacggcacc ccccgtggac tcgatcaccg
1215241 tcggctacca agcagcgcaa accggcggct actcgccacc gacaaatctg ctgatcaacg
1215301 gtcaagccgt caccatcgac cagaccccca tcacctcgtc gccaacgact ccgccaccca
1215361 ccacaccacc cgagatcccg accggtggaa cggtgatctc cacctagttc gggacgacta
1215421 cggtcaccgg aggctacgtg gtgcagaaca acgcgtggaa caacccccgc cgggcagacc
1215481 gtcaacgtca gccaaaccgg gttcaccatc accgagatga acggtgctgc cccaaccaac
1215541 ggcgccccgc tgagttaccc ctcgatctgc gagggcgtgc actggggcca cctcgtcggt
1215601 gggcaccaac ctgcctactg aggtgggcca gattttgtcg gcgccgacca gcatcgacta
1215661 caactacccg acgaccgggg tatgggacgc ctcctacgac atctgcctgg attccacacc
1215721 caagacgacc ggggtcaacc agcaggagat catgatctgg ttcaaccacc agggctccat
1215781 tcagccggtc ggctccccgg tgggcaacac caccatcgag ggcaagaact tcgtggtgtg
1215841 ggatggcagc aacggcatga acaacgcgat ggcctatgtc gcgaccgagc cgatcgaggt
1215901 ctggagcttc gacgtgatga gtttcgtcga ccacaccgcc accatggagc cgatcaccga
1215961 ctcgtggtac ctcacgagca tccgggccgg cttggagccc tggagcgacg gtgtgggtct
1216021 gggggtcgat tcgttctcgg cgaaagtcaa ctaaagacca cgttgacacc caaccggcgg
1216081 cccggcatgg gccgtcgcgg cgtagaagct ttgaccgcgg cgcgaaacgt tcgctgctgc
1216141 ggcccatgca gatcgcacac gcttgcttga acatcgggtg gagccggtgg taacgccagg
1216201 ctttgggtgt cggcgcggct cggcggtcag ctgcgcggac gcggtcggcc atcgtgacga
1216261 cgagatgctg gcggcatgta cggcaaccgc tggctcgtct tagagccatt tgctgaggcg
1216321 catgctttgc gtcatgcaaa gtgcatatgc cgccagcggg atggtgtgca ttctgtccat
1216381 gggaaaccgg gttgatggtg ggcgcgtcag cgatacgatc tgtgcaccct gacgacatgg
1216441 ccgatgcatg attgatcgga ggtaaacgat gtcgtttgtg attgctgcgc cggaggcgtt
1216501 ggtcgcggtc gcttcggatc tggcgggcat tgggtcggcg ctggcggagg ccaacgccgc
1216561 ggcgttggcc ccgacgacgg cgttgttggc cgcgggtgcc gatgaggtgt cggcggcgat
1216621 cgcggcgctg tttggcgcgc acgggcaggc gtatcagacg gttagcgccc aggcgtcggc
1216681 gtttcatgcc cagtttgtgc aggcgttgac tggcggcggc ggggcgtatg cggctgccga
1216741 ggccgccaac gtctcggcgg cgcagagcac cgaccagcgg ctgctcgatc tgatcaatgg
1216801 gcccacccag gcgttgttgg ggcgtccact gatcggtgat ggcgccaacg gcgggccggg
1216861 gcaagacggc gggcccgggg ggttgctgta cggcaacggc ggcaacggcg gcactagtac
1216921 caccgccggg gtggccggcg gcaacggtgg cgccgccggg ctgatcggca acggcggggc
1216981 cgggggcggc ggcggggccg gcgcggccgg cggcaatggc ggtgcgggcg ggtggctgta
1217041 tggcaacggc ggcgccggcg gggccggtgg gacatcggtg atacccggtg tcgccggcgg
1217101 caatggcggg gctggcgggt ccgcgggact gtggggtacc ggcggggccg gtggcgacgg
1217161 cggcaacggc cggtcggggc cagtcaacgt cgccggcagc gcgggcggca acggtggcgc
1217221 tggtggcgcc gccgggttat tcggtgacgc cggggccggt ggcaacggcg gcaagggcgg
1217281 tgctggcggc gccgccttta gcattaactt caccgcaggc gatggcggtg cgggaggtgc
1217341 cggtgggtcc ggcggccacg cattgctgtg gggcgccggc ggagccgggg gtaacggcgg
1217401 atccggcggc acggggggtg ccggcggcag caccgctggc gctggcggca acggcggggc
1217461 cgggggtggc ggcggaaccg gtgggttgct cttcggcaac ggcggtgccg gcgggcacgg
1217521 cgccgccgcc ggaaacggct tagccgcggg taatggcgtc agcagcagcg gcggcggcgg
1217581 tgccggtggg accggcgggg ccggtgggga cggtggcgcc ggcggggccg gaggcaacgc
1217641 caggctgtgg ggcgtcggtg gcgccggcgg ggccggcggg gacggtggcg ccggcggggc
1217701 cggcggcaaa ggcggctctg gcctcagcgg taacgccaac ggcggggccg gcggcgacag
1217761 cggccgtggc ggcacgggcg gcgccggcgg cgagggcggc gccgccgggc tgctggtggg
1217821 caccggcggg cacggcggtg acggcggggc cggcggcgcc gccgtcaagg gcggtgacgg
1217881 cggggccgcc gccggcacgg gcatcgccgg cgctggcggc cgtggcggcg cgggcggcag
1217941 cggtggcagc ggtggtgacg gcgggggcgg ggccgccggc cccgccgggt ggctgttcgg
1218001 cgatggcggg gctggcggga acggcggggc cgcggccgcc ggcggcgccg gcggccaagc
1218061 cggcggtggc ggcgggaacg gcggcaatgg cggcaacggc ggcaatggcg gcaatggcgg
1218121 caacggcgcc accggggggt ggctgtacgg caacggcggg gccggcggcc agggcgccac
1218181 cgccggagcc ggcggagccg gcgctaacgg cgtcagcagc accaatggcg gcggcaccgg
1218241 cggcaacggg gggatcggcg ggaccggtgg gtccggcggg gccggtggca acgccgggct
1218301 gttgggcgtg ggcggcgccg gcgggcacgg cgcctccggc ggcgccggcg ataggggcgg
1218361 cgctggcggt accgggttca taagcagtga cggcggtgct ggcggtgatg gcggtgatgg
1218421 cggcaacggc ggggccggcg gcaccggtgg gctgttgttc ggtgccggcg gcaatggtgg
1218481 ccccggcggg tctggcggtg ccgccgatat tggcggcaac ggcggcgccg gtaacggcgg
1218541 gggcaccgac gggaacggcg gtaatggcgg gtccggcggc ggcgccggca gcggcggtga
1218601 cggcggcggg gctggcggca acggtgcgtg gctgttcggc aatggcggcg ccggcggggg
1218661 cggcggaaaa ggcggcaacg gtgccggcgg cgggcttggc ggcggttcat tcggcctccc
1218721 cggcctgaac ggcagcggcg gcgacggtgg cgacggcggt aacggtgccc ccggcggggt
1218781 gctgtatggc aatggcggcg ccggcggcca ggggtcaagc ggtggcatcg gcggccccgg
1218841 cgccaccggc ggtgccggcg gcaaaggcgg tgatggtggc gatgcgcagc tgatcggcga
1218901 cggcggcaat gggggcaacg gaggcgcggg cggcaccggg ggcaccccgg ggcccggcgg
1218961 acccggcggg tccggcgggc ttggaggcct gctgttcggc caaaccggca cggctggcgt
1219021 gtcgccgtag ccggtaggct ggccgcctcc gcggcattgg cgtcgtcgca aacttcgcgc
1219081 acgccctggt gtcgatcgtt gccgctgaat tggcgccgat gaccgcaacc ggtatcgccg
1219141 ctacgccggc ccgaggcggg tacaccacgg ttttcgaggg atggcaatat ccgggagtgc
1219201 gccggctggc ggcctaactc gcctgcaccc ggcgattgga ccgccaatta cagcttgcgc
1219261 agccgcagcc ggttaatgga atgatcggcg tccttgcgca gcaccagggt ggcccgggga
1219321 cgggtcggca gaatgttctc cacgaggttg ggccggttga tggtccgcca gatctcgcgc
1219381 gcggcgacga cggcctgcga gtcagaaaaa gccgcgtagt ggtggaagtg tgattccggg
1219441 tcggcgaacg ccgtggtgcg catggccaaa aaccgtgata cgtaccactg ctcgatgtcc
1219501 tcgatccggg cgtctacata caacgaaaaa tcgaacagat ccgacaccat gagcgtgggg
1219561 ccggtctgca agacgttgag cccctccagg atcaggatgt cgggatggcg gaccacttgt
1219621 tctgcccccg ggatgatgtc gtagtgcaaa tgcgaataca ccggcgcaca tgcgtagtcg
1219681 gagccggact tcaccgaggt gacaaaccgc atcagtgccc ggcggttata gctttccgga
1219741 aaacctttgc gatgcatgag gtttcgccgc tgcagctcgg cgttggggta gagaaagccg
1219801 tcggtggtca ccagatctac ccgggggtgg tgatcccagc gagccagcag cgcctgcagc
1219861 acgcgggcgg tggtggactt gccgaccgcc acactgccgg ccacaccgat gatgaacggc
1219921 accggccggt ccgggttttg ttggggctcg ccgagaaatt ccgcggtggc cgcgaacagc
1219981 cgttggcggg cggcgacttg caggtgaatc agccgggcca gcggtaggta gacctcttcg
1220041 acctccaaca ggtcgatctg ctcaccgaga ccgcgcaggc caaccagttc ttcttcggtg
1220101 agggctagcg gagtcgacat acggagcgcg cgccactgcc ttcggtcgaa ctcgacatat
1220161 gggctcggct cgctaagccg cgacatggtg tcagtcttgc agggacgggt gcggggcctg
1220221 atggctgggc tggcgaagtg cggtgctggc agactccgtg tcggtgccga gggccggggg
1220281 taccccctgg gcttagctgg gcactggggc cagggcgcgg tgtttcgatg gaattcagct
1220341 gtggccctgt gaatttcgca cgctgacgcc ggttgatgct gtgagtcggg cacaaaccgc
1220401 ccaccgctac tcgtgaccta cgtggcagct ggggcactag tggctgccgt ttgcggtgca
1220461 gacgtgcaac ggtggatggc gtgtgctgca ttaagggtaa tcagcccggg agcggctcgc
1220521 tggatacact ggcgcccgtg actgctgcac ctgacgctcg cactaccgcg gtaatgtctg
1220581 ccccgctcgc tgaggttgac cccgatatcg ccgagttgct ggccaaggag cttggtcggc
1220641 aacgagacac cctggagatg atcgcctcgg agaacttcgt accgcgcgct gtgctgcagg
1220701 cccagggcag tgtgctgacc aacaagtacg ccgagggact gcccgggcgg cgctactacg
1220761 gcggttgtga gcacgtcgac gtggtggaaa acctcgcccg cgaccgagcc aaggcgttgt
1220821 tcggtgccga attcgccaat gtgcaaccgc attcgggcgc tcaggccaac gccgcggtgc
1220881 tgcatgcgct gatgtcaccc ggcgagcggc tgttgggtct ggacctggcc aacggtggtc
1220941 acctgaccca tggcatgcgg ctgaacttct ccggcaagct ctacgagaat ggcttctacg
1221001 gcgtcgaccc ggcgacacat ctgatcgaca tggatgcggt gcgggccacc gcactcgaat
1221061 tccgcccgaa ggtgatcatc gccggctggt cggcctaccc gcgggtgctc gacttcgcgg
1221121 cgttccggtc gatcgccgac gaggtcgggg ccaagttgct cgtggacatg gcgcatttcg
1221181 cgggtctggt cgccgcgggg ttgcacccgt cgccggtgcc gcacgcggat gtggtgtcca
1221241 ccaccgtgca caagacgctc ggcggcggcc gctccggcct gatcgtcggt aagcagcagt
1221301 acgccaaggc gatcaactcg gcggtgtttc ccgggcagca gggcggtccg ctcatgcacg
1221361 tcattgccgg caaggcggtc gcgttgaaga tcgccgccac acccgaattt gccgaccggc
1221421 agcggcgcac gctgtccggg gcccggatca ttgccgatcg actgatggct cccgatgtcg
1221481 ccaaggccgg tgtgtcggtg gtcagcggcg gcaccgacgt ccacctggtg ctggtcgatc
1221541 tgcgtgattc cccactggat ggccaggccg ccgaggacct gctgcacgag gtcggcatca
1221601 cggtcaaccg caacgccgtc cccaatgatc cccgaccgcc gatggtgacc tcgggcctgc
1221661 ggataggcac gcccgcgctg gcgacccgcg gcttcggcga caccgagttc accgaggtcg
1221721 ccgacattat tgcgaccgcg ctggcgaccg gcagttccgt tgatgtgtcg gcgcttaagg
1221781 atcgggcgac ccggctggcc agggcgtttc cgctctacga cgggctcgag gagtggagtc
1221841 tggtcggccg ctgacgcggg cctgtcgttg gcgcgcataa gcgcgagagc gccgatcacc
1221901 gcgcgacacg gcggcgcccg atttcacgaa atctgtgtat gcgagttaca gttaccgcat
1221961 ggcacagaaa cctgtcgctg atgcgctgac ccttgagctc gagccggtgg tcgaagcgaa
1222021 catgacccgc cacctcgaca ccgaggacat ctggttcgcc cacgactacg tcccgttcga
1222081 tcagggggag aacttcgcat tcctcggcgg acgcgattgg gatccatccc agtcgacgct
1222141 gcccagaacg atcaccgacg catgcgagat cctgctgatc ctcaaggaca acctggccgg
1222201 tcatcaccgt gagctcgtcg agcacttcat actcgaggat tggtggggcc gctggctcgg
1222261 ccggtggacc gcagaggagc acctgcacgc catcgcactg cgcgaatacc tggtggtgac
1222321 ccgggaagtc gacccggtcg ccaacgagga cgttcgagtc caacacgtga tgaagggcta
1222381 ccgagccgag aagtacacgc aggtcgagac cctggtgtac atggcgttct acgagcgctg
1222441 cggcgcggtg ttctgtcgta atctggccgc gcagatcgaa gagcccatcc tggccggact
1222501 catcgaccgc atcgcccgag acgaagtgcg acacgaggag ttcttcgcca acctcgttac
1222561 gcactgcctg gactacacgc gtgacgagac gatcgcggcg atcgccgccc gtgccgccga
1222621 cctcgacgtc ctcggggccg acatcgaggc ctaccgagac aagctgcaga acgtggccga
1222681 cgctggcatt ttcggcaagc cgcagctacg gcagctgatc tcggaccgca tcacggcatg
1222741 gggcctggct ggggagccct ccctcaagca attcgtcacg ggctagacac ccgtcggcgc
1222801 gcctgccctg cgggggtacg gccggcggag tagcgtcgca ctcgatggct agcgacatgc
1222861 tctgctgcca gggcggcacc ttccgtcacg acggctgtca tgacaagggc aggaccggcc
1222921 ccggtcctgg tgtcgctgcc cccgccgaca tgctcgggtg ggtccgctcg agcgccgtta
1222981 gctcgaggag cgctccgtga ccgatacccg cacgtacgtg ctcgacacct ctgtgctgct
1223041 gtccgatccg tgggcgtgca gccggttcgc cgaacacgat gtggtggttc cgttggtggt
1223101 gatcagcgag ctagaagcca agcgccacca ccacgagctg ggatggttcg cccgccaggc
1223161 gttgcgtctg ttcgacgatc tgcgcctaga acacgggcgg ttggatcagc cgattccggt
1223221 tggcacccaa ggcggtacgc tgcacgtcga actcaatcac accgacccgg cggtgctgcc
1223281 cgcaggcttt cgcaccgaca gcaacgactc gaggatcttg agttgcgccg ccaacctcgc
1223341 cgccgagggc aagcgggtca cgttggtcag caaggacatt ccgctgcgcg ttaaggccgc
1223401 cgcggtgggg ctggccgccg acgagtacca cgcgcaggac gtcgttgtgt ccggatggtc
1223461 ggggatgcac gagctcgaga ccgcttccgc ggatatcgat gcgttgttcg ccgatggcga
1223521 gatcgacctg gtcgaagccc gggacctacc gtgtcacacc gggattcggt tgctgggcgg
1223581 cggttcccac gcgctgggcc gggtcaatgc gcataaacgt gttcagctgg tgcgaggtga
1223641 ccgtgaggcg ttcggtctgc gtggccgctc cgccgagcag cgggtggcgc tggatttgct
1223701 gctcgatgag tcggtgggca tcgtgtcgct gggcggcaaa gccggcacgg gcaagtccgc
1223761 tttggcgttg tgtgcgggtc tggaagccgt gctggagcga cgcacccacc gcaaggtggt
1223821 ggtcttccgc ccgctgtacg cggtcggcgg ccaggagctg ggctacctgc ccggtagcga
1223881 gagcgagaag atgggcccgt gggcgcaggc ggtcttcgac accctcgagg ggctggccag
1223941 cccggcggtg ctcgaggaag tgctgtcccg tggcatgctc gaggtgctgc cgctgaccca
1224001 catccggggc cgctcgttgc atgactcgtt cgtcatcgtc gacgaggcac agtcgctgga
1224061 gcgcaatgtg ttgctgaccg tgctgtcccg gttggggacc ggttcccggg tggtgttgac
1224121 ccacgacatc gcccagcgcg acaacctgcg ggtcggccgc cacgacgggg tcgccgcggt
1224181 gatcgagaag ctcaaaggtc atccgttgtt cgcccacatc accttgctgc gcagtgagcg
1224241 ctcgccgatc gccgcgctgg tcaccgagat gctcgaggag atcaccgggc cgcgctgagt
1224301 gcgcctcccg cgagcagaca cagaatcgca ctgcgccggc ccggcgcgtg cgattctgtg
1224361 tctgcttgcc ggtagacttc ctgggtgccg aagcgacccg acaaccagac ctggcgctac
1224421 tggcgcacgg ttaccggtgt cgtggtcgcc ggtgcggtgc tggtggtggg cgggcttagc
1224481 ggccgggtca cacgggcgga gaacctgagc tgttcggtca tcaagtgtgt cgcgttgacc
1224541 ttcgacgacg gtccggggcc ctataccgac cggctgctgc acatcctgac cgacaacgac
1224601 gccaaagcca ccttcttcct gatcggcaac aaagtggccg ccaaccccgc cggcgcccgg
1224661 cgcatcgcgg acgcgggcat ggagatcggt agccatacct gggaacaccc caatatgacc
1224721 acgattccgc ccgaggatat ccccggccaa ttctccaggg ccaacgatgt gatcgccgcg
1224781 gcgaccggcc gcacgccgac gttgtatcgc ccggccggcg gactgtccaa cgatgcggta
1224841 cgccaggccg cggccaaggt tgggcaagcc gaaatccttt gggacgttat acctttcgac
1224901 tggatcaacg actccaacac ggcagcaacc cggcacatgc tgatgacgca gatcaagccg
1224961 ggttcggtgg tgttgttcca cgacacctac tccagcaccg tcgacgtggt gtaccagttc
1225021 atcccggtgc tcaaagccaa cggctatcgc ctggtgaccg tcagcgagct gctcgggccg
1225081 agggcgccag gaagcagtta cggcagccgg gaaaacggtc cacccgtcaa cgaactgcgt
1225141 gacattccgg ccagcgagat cccgccgttg cccaacacct catcgcccaa gccgatgccc
1225201 aacttcccga tcaccgatat tgcgggtcag aattcgggcg ggccaaataa cggtgcgtaa
1225261 cctcaggact tgttgacctt cagcgcctca atgaccctct cgacggtggc gcgcgaggtt
1225321 gcatcaccga tgggggtggc gcccaggaag acggtgaccg gcttggtgtc gaccgcgatg
1225381 atcgtgaccg aatcaccttt gacgttgcgt gaactgtcgg cgattgtgat atcggcgtct
1225441 acccgggcgg ccctgacccc gtcgacggtg atcgacgacg tcttggtcgg gcccagggtg
1225501 ggcgacgagc ctgcgtagcc ggggccgtcg gccacgcatt gcatcaactt cgatgcttgc
1225561 gcggcgacgt ccatggtggt gacgaagttg gttatcgcaa cctcggcttg catcatccac
1225621 tggtcggcac cggccacctc gtggccgacg cccaccgcgt cgatgaggtt cgggttctgg
1225681 tcgtcggaga acgccgacca cccgggtgcc gcgctggtcg ggaacgacag cttacccgca
1225741 ctgatcgaat cgccgatggg ctgcacaccg ccggacacat ttggggtaca accggttgcg
1225801 gtttgctggg aaaacggttg cgacgtggga gcactcgtcg ccggagaggt tgccgtggtc
1225861 gacttgttgt cgccgcggag gccgatcacc aggatcacca ccagtaggat gacacccagc
1225921 accgcgaggc cggcgaggat cagccacggt gtcttcgatc ctggcccggg cggaggtggt
1225981 cctggcggat agggccccgc cggccagccg ggcggatact gctggggtgg gtaggccggc
1226041 ggataggagc cgccctgcgg ttggcctccc caatacgggt cctgcccata cgtattcggg
1226101 ccgtaggggt agttgccgta ggggccagcg ggaggaaccg tcatagccga tcgctgtcga
1226161 gctgctcggc cttggccatt gccagcacgt ccagacggcg gtccagatcc tcgatcgaca
1226221 gcctgtcgcc gatcaggcca cggtcgatca cggtttggcg aatcgttttg cgttccttga
1226281 gtgcttgctt ggcgacggcg gccgcctcct cgtagccgat ggccgaattc aacggtgtca
1226341 cgatcgacgg tgaggactcg gccagccgcc gcaggtgctc gacgttggcg gtcagccctg
1226401 ctatgcagcg ctgggcgaac agccgtgaca cattggtcag cagcttgaag gactcgagga
1226461 tgttgcgggc catcatcggg atgtagacgt tgagttcgaa tgcgccgttg gccccacccc
1226521 aggcgatggc ggcgtcgttt ccgatcacct gcgcggcgac ctgcgtaacc gcctccggca
1226581 gaaccggatt cacctttccc ggcatgatcg agctgcccgg ctgcagatct ggcagttgga
1226641 tctcggccag gccggtcaat gggcccgatc ccatccagcg gatgtcgttg gcgatcttgg
1226701 tcagcgatac cgcgatcgtg cgcagcgccc cggacgcctc caccagcccg tcgcgggcag
1226761 cctgagcttc gaaagaatta gccgccgtac gcaattccga cagaccggtc tgcgcgacca
1226821 gcaccgcgac cactctgacg ccgaagtcgt cgggagcgtt gaggccggta cccaccgcgg
1226881 tgccgccgat cgccagctcg cccagcctgg gcagacacgc gcgcacccgc tcgatgccgg
1226941 cctcgatctg gcgggcatat ccgctgaact cctggccgag tgtcaccgga acggcgtcca
1227001 tcagatgcgt tcggcccgac ttcaccaccg tgtgccaatc aagagccttg gcggccaatg
1227061 cgtcgtgcag ctgctgcagc gctgggatga gatgagcgac cgcggcctcg gtggccgcga
1227121 tgtgggtggc cgtcgggaag gtgtcgttgg acgactgcga catgttcacg tcgtcgttgg
1227181 gatgcaacgt gaccccgccc ttggccgcga tggacgcaat cacctcgttg gtgttcatgt
1227241 tggagctggt gcccgagccg gtctggaaga cgtcgatggg aaactggtcg tcgtgttgac
1227301 cgtcggcgat ctcggcggcc gcggcgatga tggcgtcggc tttctccggc gccagcaacc
1227361 cgaggtcgga gttcacctgc gcgcaggcgc ctttcagcag gcctagcgcg cggatctggg
1227421 tgcgctccaa cccgcggccg gatatcggga agttctccac cgcgcgctgg gtttgcgcgc
1227481 gccacaacgc ttttgccggc acccggactt cgcccatggt gtcgtgctcg atgcggtaat
1227541 tggcgctgtc ggcgtcaacg gccattgatc gggttccttg tgtgtcgtgg gtgtgttagg
1227601 gcaatgggta cacggcgctg ctgtcgccgg tgaagtcgat cgcggagtat tcgttgagct
1227661 ttgaaagccg gtggtaggcc tcgatcatcc ggacggtgcc ggacttcgag cgcatcacga
1227721 tcgaatgggt ggtgcagccg ccggggtagt aacgcactcc cttgagcagg tcgccgtcgg
1227781 tgaccccagt ggcgcagaag aagacgtttt ccccggacac cagatcttcg gtggtcaaga
1227841 cctggttcag gtcgtaaccg gcttctaggg ccttgcggcg ttccgcgtcg tcgcgcgggg
1227901 cgagctgcgc ctggatcgcc ccgcccatgc agcggatcgc cgcggcggcg atgattccct
1227961 ccggggtgcc gccgatccca gctagcaggt cggtgccgga gtgcggtcgg cacgccgaga
1228021 tcgcgccggc gacgtcgcca tcggtgatca gccggatccg ggccccggtg gcgcggacgt
1228081 cgtggatgag ttgcgcgtgc cgcggcctgt ccaggatgca caccgtcatg tctcgcaccg
1228141 acaggtcctt gaccttggcg accgctcgga tgttttccga gatcggcgcg gtgatatcca
1228201 gcacgtgtgc ggcatcgggg ccgacggcga ttttgttcat gtagaacacc gccgacgggt
1228261 cgaacatggt gccgcgatcg gctaccgcca gcaccgagat ggcgttggtc atgcccttgc
1228321 tcatcagcgt ggtgccgtca atggggtcga cggcaaagtc gcattccggt ccgtcgccgt
1228381 tgcccacttc ttcgccgttg tagagcattg gtgcgtggtc cttttcgcct tcgccgatga
1228441 ccaccacccc gcgcatggaa accgagttga ccagttcgcg catcgcgtcg accgccgcgc
1228501 cgtcgccgcc ctccttgtcg ccgcggccta cccagcggcc cgcggccatg gctccggcct
1228561 cggtcacccg gaccagctcc atggccaggt tgcggtccgg ggcttcccgg cgcgatggcc
1228621 tggtgtgcga cgggtcgtgg ctggccaccg cggccgtcga cgaaccggat ccctcagctg
1228681 tcatggttgg tgattgtccc agaagccgaa ccgtgcgctg gagctgggat actggccatg
1228741 tgaccgccga gccgcagccg acccctaggc cggctaaacc gcggttgctg caggacggcc
1228801 gcgacatgtt ctggtcgctc gcgccgctgg tcgtggggtg catcctgttg gcgggcctgg
1228861 ttgggatgtg ctcgtttcaa ctgggcggga ccaagcgggg accgatcccg tcctacgatg
1228921 cggcccaggc gctgcgggca gacgccaaga cgctgggatt cccgatacgg ttgccgcaat
1228981 tgccaggcgg ctggacgccc aactccgggg gtcgcggcgg catcgagaac gggcgagcgg
1229041 acccggcaac cggtcaacgc cgcaacgcgg cgacctcaat cgtgggattc atcagcccga
1229101 ccgggagata tctgagcttg acccagagca acgccgacga ggacaagctg gtcggctcca
1229161 tccacccgtc gatgtacccg acggggacgg tcgacgtggg cggcacccgt tgggtcgttt
1229221 acgagggttc ggacgaaaac ggtgccgtcg agccggtatg gacgacacgg ctcaccggac
1229281 cgggcggggc cacccagctg gcaatcaccg gtgccggcag catcgatcag ttccgcacgc
1229341 tggcgtcggc gacgcaatcg cagcccccgt tgcccgcacg atagcgggtc tcactcagcg
1229401 gttgacggag gcggggcgtt tcttgacgtg gccgggcctc gacgcggcag ccacctgcgg
1229461 cggacgggtg gtgcttcgaa ctgttccagt tcgacgcctt tgtacaccgc gaggtagacg
1229521 tcgatggtgg tgacgatgag gatcatcagc accgggccga tgatgatacc ccaggggccg
1229581 aacatggtga taccggcgaa caccgacagc aacatcagcg ccgagttcag ccgcgcgtcg
1229641 cgcggcacca ggatcggccg caggacgttg tcgatgttgg taaccaccag cagatgccac
1229701 agcagcacga agattccccc ggcgatattg ccgtagaaga tcatcccgat gccgaacgga
1229761 atcgtcacga tgccgccgcc cagcgggatg atcgacaacg cggtgagcac gatggcgaag
1229821 atgaagaagc cgtggtgaaa tccggcgatg tagatcgatg cggcgccggc gactccctgg
1229881 cacgccgcga tgacgaactg gccgttcacc gtgccgcgga ccatcgagcc catcttctgc
1229941 aggtacagat ccgtgacgtc ttcgccgagc gggttgagct ggccgatcag tgtccttagc
1230001 ttctcgcggt tcaccaagag cgcgacgaac acgtacacaa agatgatggc cgacgtgatg
1230061 acaccggcga ggcttccggc ggcgtcgcgc aggaagtgca gcagccattc gccgacgttc
1230121 tgtgctaccg aaatcatcgc tttgcgcagt gcgtccgcgg taaccgtgat gtgcaggaac
1230181 ggcacccggt caaacaagcc gttgacgaat tgcaggatct tgtcgccgag ggtgctcaga
1230241 tcggtcgtcc gcacccagtc ggcgacggag tcgaccatgc gagcgatctg cacgatcgcc
1230301 agccccacca aggctcccac cggcacgacg acggcggcca gcgccgacaa caacgtgcag
1230361 gcggccgaca ggccggtatt gaagcgcttg gtgaaccact tgaaaagtgg cgtgaacaaa
1230421 taggcgccga cggctgccac cacgatcaga acgaaatagt tacgcaggaa gtacgcaccg
1230481 aacagcaaag cgatcaacgt gaggatcgcc agggcgcgct tctgagtgag cgtgaattcg
1230541 gtgttcaaag cgggtccgcc cttcgcttct tggtgctgac tctgcgtcca gcaggcgggt
1230601 tactcgcact attgcgtggt ggatgcagag tcaacggatg tcggtgcagt gctgtagacc
1230661 tatgccacca cccaatcgag gtcgaacgcg ttgccgatgg cctcggctag agccggctcc
1230721 tgcgacgcga gcaggtagcc gatttgacga ccaaggtcac acaccgggat cgtttgggtg
1230781 ttgtcgcagc tgacgactga cggttgattc agcccgttca ccgcgtctac cgggacttcg
1230841 gtggctagcc cacgcacggt tgtcgtgatc ggggcgacgg tgacgttcgt gaggtgcgga
1230901 cgtacgacct cgcgggtaag gatcaggacg ggtctagcct tgtcaagctg tgcgatgtgg
1230961 ataggtcgca tcagtcgatg tcgagggcgg tacgagcgca gtggccggcc agcgtatcca
1231021 gatcacccgt ggctgacgtg ttggtggcga ggatctccgc gtcgcgttcg gcgagacgac
1231081 ggcggcgttc ccgttccagc gcccgcagca cgacagccgc acggctacgg gcatgctgtc
1231141 cccggacttc gtcgtcgatg aacgcgacaa tctcatcggg caagcgaacc gcaatctgtg
1231201 tactcacttc acagatggta ccagtttggt atgcacccgc cccaaaaccg ttcgcgccgc
1231261 cggcgaggac gaccccccag ggtaggtaca ttccagaagt atggtcgtcg acagctgcgt
1231321 ggccgaatcc cgctatggtc cggtccgggg cgccgatgat ggccgcgtca aagtgtggaa
1231381 aggcatccgg tatgccgcgc caccactagg tgacctgagg ttccggacgc ccgaacctcc
1231441 cgaacggtgg accgaggtcg ccgacgccac aaccttcggt ccggcctgcc cgcagccggc
1231501 catccccaac atgccgctcg atttaggggc gtcgcagagc gaggactgtt ggagcctgaa
1231561 catttgggcg ccggcggaca ccgagcccgg tgacggaaaa cccgtgatgg tgtggctgca
1231621 cgggggcgcc tacatcctgg gatcgggcag ccagccgctc tataacggcc gcaggttggc
1231681 cgccagcggc gacgtggtcg tggtgacggt caactaccgg ctcggagcgc ttggcttcct
1231741 ggacttgtcg tcgttcaaca cgtcacggcg acggttcgac tcgaatatcg gcctgcgtga
1231801 cgtgctggcc gtgctgcgct gggtagcaga caacatcgcg gtgtttggcg gcgatcccga
1231861 gaaggtcacg ctgttcggtg aatccgcgcg ggaatcgtca cgaccctgct cgccaccccg
1231921 gcggccgcgg gtctgttcgc ggcggcgatc gcccagagct caccggcgac atcggtctac
1231981 gaccaggtga gggctcggcg cgtcgcggtt tgcgtcctcg acaagctggg aatcgacccg
1232041 tccgatgtgc acaggttcat gaagtgccga ccgcggcaat cctttccgcg tccagcgaag
1232101 tgttcaacga agtgccggtt cgtaaccccg gcacgctggc gttcgtcccg atcgtcgacg
1232161 gcgatctgct gcccgactac ccggtcaagc tggcgcagga gggccgctca cacccggttc
1232221 ccttgatcat cggcaccaac aagcacgagt cggcgctctt tcggttgatg cgctcgccgc
1232281 tgatgccgat caccccgcgc gatcacgtcg atgttcaccc agattgccgc cgaacagccc
1232341 gatctgcaag tgccaaccga ggagcagatc ggctccgcgt actcgcgatg gcggcgcaaa
1232401 gcacgctcat tgagtatggc taccgacgtc ggcttccgga tgccgtcggt gtggctcgct
1232461 gaagggcaca gcggggtggc gccggtgtat ctgtatcggt ttgactactc gactccgctg
1232521 ctgaagctgc tgctggtccg ggccgcccat gccaccgaat tgccttacgt ctggggcaat
1232581 ctcggaggat cccaggaccc tgcattgaag ttgggcgacg ccaaagccgc catagcggtg
1232641 tcccggaggg tacggacgcg gtggatcaat ttcgcgacgc ggggcaaacc cacgggtccc
1232701 gatggcgagc cagactggcc atgttacgag gaggcccatc gtgcctgcct gattatcggc
1232761 aggcgagacg ccgtcgtgca cgacgtcgac gcacacatcc gagcgacctg gggcagcaag
1232821 tggtgagttt cagataattc tggctacggc ttgactgtgg cggccgtttt ttccgcccgg
1232881 gcctcgttct tcatctgctc aaacagactc acgtagtacg gcaggcattc ggtcagcgcc
1232941 tgctgggtgg tgaacagcgg ctcatagccc aggtcgcggc gtgccttagc gatcgaaaag
1233001 tagttgtcca ggtacagtcg ttcgacggcc agcggctcga gcagcggcgc ggggaatccg
1233061 aaccggaagt gcagccgctg ccaccccgtc attacccagc ggaccgcggg gccggaaatc
1233121 cgcatcttcg gccagcgctg cccgcacgcc tcgagcaccg gccgagcgaa ctcgaacata
1233181 ttgatcggct ctgcgtcgtt gatgaagtaa gcctgcccgg gcgctgtgcc gtccggcacc
1233241 agatgggcag cggccaagat gaaaccgtga atcaggttgt gcacgtaaga gttatccagc
1233301 cgggccgact tgcgcccgac cagcaccttg acgtggccct tgagcacact ttcgaacagc
1233361 ttgcggaaca tcgtctgatc gccgtttccc cagatgccgc tgggccggat cgcgcacgtc
1233421 agcatgccgt cgacaccgtt ctgggccaac acgaatcgct cggcaaccac cttggtctcg
1233481 gtgtagaggt cgttgaaccg gtcggtatag ggcagcgtct cgtcaccgcc ggcgatgttc
1233541 tggccgccca tcaccacact gttggatgac gtgtagacga accgctgcac cccggcccgc
1233601 tggccggcgt gcagcaggtt ctcggtgccg ccgacgttga ccgcaaagct acgttggcgg
1233661 tactcgtcgg tgaccgacgc gccgcccatc agctcgatga tcgctgcggt gtggaagatc
1233721 gtgtcgatgc cgtccacggc cgcggcgcag acgtccgcgt cggtgatgtc cccttgcagc
1233781 acctccagtt gcggatgcgc aggcaacagc gacggcgcgc ggtcgaagga acgcacccag
1233841 tgcccgcggt ccagcaaggt ggtcaccagg ttggcgccca cgaagcccgc gccgccggtg
1233901 accagaacgc ggccgagctc ggttgtcagc gatgcatcac ccatgcggcg aagcataacc
1233961 ttgccttagc cgttttgggc ctcgtcgccg gccagcacat cggacacccg ctggcgtgca
1234021 ccagctaagt gctcctcgca ccttttggcg agttgctccc ctctttccca cagtcgcagc
1234081 gacgcatcga ggtccaatcc gccctgctcc agaagccgca cgacttccat cagctcgtcc
1234141 cggcaggctt catagccaag ctgactgaca ggcacagttg cgtgggttct gcccgtgtca
1234201 tcgccgttgg ggtcacagac cattggtttg tccttcactg accgccgcta gggctccgtc
1234261 ggcaacccgc acgcgcagct tggtgccttc cggtgcgtcg tggaccgacc gcagcacctg
1234321 tggttcggat ccgccctcgg gtcccgtctg agcaacggtc tgcactatgg catagccgcg
1234381 ggcgagcgtg gcggccggac ccagcgtggc caggcgtgcg gccagatgac cgatgcgttc
1234441 ggtctcggcg gcgaccatca gggtgaggtt gcgacgaagc gtcgagcggg ctcggtggac
1234501 ctcctcggcg cgcacgctga ccatcgtcat cggatcggcc agcaccgggc ggctacgcaa
1234561 ctgcgcgact gcccgttgct cgcgggaaac ccagttgcgc aacgcctggg cgctgcgccg
1234621 gcgcagatcg tcgatcagcc gctgctcggc tgcggtgtcg ggaaccactt tcttggcggc
1234681 gtcggtgggg gtggcggcgc gcaggtcgac gaccagatcg cacagcggat tgtcgggttc
1234741 gtgaccgacg gcgctgacca cgggcgtacg gcaggccgcg atcgcgcggc acaacgtctc
1234801 gtcagaaaac ggcagcaggt cctcgacgga gccgccgccc cgggccagca cgatcacgtc
1234861 gacgtccggg tctcgatcga gctcgcgcag cgcctcgacg atctggccga cggcgttggg
1234921 gccctgcacg gcgacgttgc ggacggcgaa acgtgccgct ggccagcgcg ccgaggccac
1234981 cgtcgtaacg tcacgttcgg cggcactcgc acggccggtg atcagaccga tcatgttggg
1235041 caggtacggg atcggccgct tgaggcgggg gtcgaagagc ccctcggcgt ccagcagccg
1235101 gcgcagccgg tcgatgcgtg ccagcagctc gccgatgccg acagcgcgaa tctcgctgag
1235161 ccgcaaggag aatgtgccac gtccggtgta gaacgagggc ttgccgcaga ccactacctg
1235221 aacgccttcg gccagcttca ccggcgcgga cagcaccagg tcgcgggaac acgtcacggt
1235281 cagcgacatg tcggccgcag gatcgcgcaa taccatgaac accgtcttgg cgtctgggcg
1235341 cattgtgatc tgggccaatt gcccctccac ccagaccgcg cccagcttgt cgatccagcc
1235401 cgcgacccgg attgccaccg cgcgaaccgg gaacggattc tccgctgaat tctgggtcac
1235461 ttcgcagtcg cgcgggtgat cctgttggcg agcagcgtct ggaacggggc acgggccttg
1235521 gtggcctgct cgtaggccag cagggcctcg agctcgggga catcgagcgt gtgcagcctg
1235581 gcccgcagct gggccagcgt cagcgccgga tagtcgagtt cggctgccac cgcaggcgtc
1235641 ggaactgtcg gcttggccgc cgacttgggg tgcttggcgg ttttgggatt ggtcgagcga
1235701 tccgcactcc tggatgctgt cgtcgtttcc ggcgtatcgg ataccgagta caacgcgaac
1235761 cgcccgtcgg accggcgatc gtcgttcttg gcttcgctgg catccgacaa gccgagcaat
1235821 ggaatcgaag tcccttcgag cgcgtcgggc aagtcctcgt cgaatgttgc ccactccggc
1235881 ttctcgtcct tgggcggaaa cagcgtctcc agggtgttgt cgcccttgat caccagttcg
1235941 gccaggccct gttggaatcg catcaccacg tgcgccgcct ggctggccag ggtcattggg
1236001 tacatcagga tggttcgtgg cagcttcatc gtctcctcaa cggcgactgt cgccgcgccg
1236061 accaatagcc gaaccccata cggtgcagta gccatggatc caagactgcc tcaagcagcg
1236121 gctaactcca agccggtggc cgtgagctgg cgggttcgtg tcggcccaaa gtaccctgaa
1236181 tgccatggtt ccgacggtcg acatggggat tcccggggct tcggtatcgt cgcgatcggt
1236241 ggccgaccgt cccaaccgta agcgggtgct gctggccgag ccgcgtggct actgcgctgg
1236301 cgtggatcgg gccgtcgaaa cggtcgaacg cgcgcttcaa aaacacggcc cgcctgtcta
1236361 cgtgcgtcac gagatcgtgc ataaccgcca cgtggttgac accctggcta aggccggtgc
1236421 ggttttcgtc gaagagaccg agcaggttcc cgagggagcg attgtggtgt tctccgcgca
1236481 cggggtcgcg cctacggtgc acgtcagcgc cagcgagcgc aacctgcagg tcattgacgc
1236541 cacctgcccg ctggtcacca aggtgcacaa cgaggccagg cggttcgccc gggacgacta
1236601 cgacatcttg ctgatcggtc atgagggcca cgaggaagtc gtcggtactg ctggggaagc
1236661 tcccgatcat gtgcagctgg tcgacggggt ggacgccgtc gaccaggtga ccgtccgtga
1236721 cgaggacaaa gtggtttggc tgtcgcagac caccctgtcc gtcgatgaga ccatggagat
1236781 tgtcgggcgg ttgcgtcggc gtttccccaa gctgcaggat ccgcccagcg acgacatctg
1236841 ctatgcgacc cagaatcggc aggtcgcggt caaggcgatg gcgcccgagt gcgagctggt
1236901 catcgtggtc ggctcgcgca attcgtcgaa ttcggttcgg ctggtcgagg tggcgctggg
1236961 tgccggggcg cgggccgccc acctggtgga ctgggccgac gatatcgact cggcctggct
1237021 ggacggcgtt accacggtcg gcgttacgtc gggggcatcg gtccccgagg tgctggtgcg
1237081 cggtgtgctg gagcggctgg ccgaatgcgg ctacgacatc gtgcaaccgg tgacaacggc
1237141 caacgagacg ttggtgttcg cattgccccg ggagctccgc tcacctcgct gagcacatcc
1237201 gctcacggtt agacgtcgta ttcccaggat tcagccggtg gtctgcgcgg tgcccgcgaa
1237261 cgatcccgcc gatcgaaccg ctgctcctcg cggtagttgt cccgccgcgc gtcgcgagta
1237321 gctgacccgc ggtagcggac ctgcgagatc ggatggtgtg tcgggttggt tggctcgctg
1237381 ggacgggcgc gtcggcgttg gggctcgtag gtgggctcgt agcgcgcata gggctggtat
1237441 cgagcacccc gacgttcgta ccggttgacg ggctcggcag gcccggaggg ttcggacggc
1237501 tggtagctgc ggtaagaatc gaagcggctg ctgcgcggtg ccggccgttc gtgggcattg
1237561 cggcgcgggt gcggatcatt ctgcggccta gggcggcggc gcgatcgacg ctcggctatg
1237621 ggttcgcggt tgtcctccga cgggggtcgg gcgtgtcggg aacgagtacg ggcaggccgc
1237681 tgggccgacc gccggccgcc gtcgtcgtcc gaatcgccgg tcatcagcga gctgagcttc
1237741 ctggcgatgc tgtcgaacag agccgtcccg agataccacc tgaccagtcc gatcagcagc
1237801 acgccggcag ccgtgcccag catcagcggg aaacgttcga tgagcgagta gccgcagttg
1237861 atcaagaggt ctttgaactt gccgatcgtg cccccgtgga acagccagta ggccccgggc
1237921 acggcgcaga aaagtatcag tggcggctgg acgagcgcgg tgaacaggtc cgactgccgg
1237981 acggccagga ccgcccccac gcagccggcg atatagcagc cggtaaagac gagggttagc
1238041 gccttgtggc ccgatccggc gtcgattgca tacccgatcg ccgtcgcggt gacggcgatc
1238101 aggatggcag cccaccacgg cacacctggg atgtgggggt gaatcgagcg gtgacttgcc
1238161 tgtaccgccg acctcgcccg ctgcgctgac acacgtcgac cgtaccggca atggcgccga
1238221 aggcggcacc gcctcgcctt aaacttggct ctctgtgagc ttgagcctgg ggatcgtggg
1238281 cctgcccaac gtcggcaagt cgacactttt caacgcgctg acccgaaaca acgtggtcgc
1238341 ggccaactac ccgttcgcga cgatcgaacc gaacgaaggt gtcgtctccc tgcccgatcc
1238401 ccgcctggac aagcttgctg agcttttcgg atcgcagcga gtcgtacccg cgccggtcac
1238461 cttcgtggat atcgccggcc tggtcaaggg ggcgtccgag ggagccgggc tgggtaacaa
1238521 gttcctggct catatccgcg aatgcgacgc catttgtcag gtggtgcggg tgttcgtcga
1238581 cgacgacgtg actcatgtca ccggacgggt cgatccccag tccgacattg aggtcgtcga
1238641 gaccgagctg atcctggcag atctgcaaac cctggagcgg gccacgggcc ggctggagaa
1238701 ggaagcgcgc accaacaagg cgcgcaagcc ggtctacgac gcggcactgc gtgcccagca
1238761 ggtgctcgac gccggcaaga cgctgttcgc cgcgggggtg gatgccgccg cgttgcgcga
1238821 gctgaacctg ctgaccacca agcccttcct gtatgtgttc aacgccgacg aggcggtgct
1238881 caccgacccg gcgcgagtcg gtgagctgcg cgcgttggtg gcgcccgccg atgcggtgtt
1238941 cctggacgcc gccatcgagt cggagttgac cgaactggac gacgagtcgg ccgcggagct
1239001 gctggagtcc atcgggcaga gcgagcgcgg gctggacgcg ctggcccggg cgggttttca
1239061 caccctgaag ttgcagacct ttttgaccgc gggccccaag gaagcgcggg cgtggaccat
1239121 ccatcaaggc gacaccgcgc cgaaggcggc cggggtgatc cacagcgact tcgagaaggg
1239181 tttcatcaag gccgagatcg tgtcctacga cgacctggtg gccgcgggtt cgatggcggc
1239241 ggccaaggcg gccggcaagg tccggatcga aggcaaggac tacgtgatgg ccgacggtga
1239301 cgtagtggag ttccgattca acgtgtaggc gggaaagccg ggacgcagcc agagcccaga
1239361 tcccatggca tcattgcttg catcgagtga tgcatgtatt gatgggagtt ggtgaatgag
1239421 gacgacggtg accgttgacg acgccttgtt agccaaagcg gccgaattga ctggggtgaa
1239481 agagaagtcg acgctcctgc gcgaggggtt gcagacactg gtccgggtgg agagcgcccg
1239541 gcggttggcg gctctcggcg gcaccgaccc gcaagctacc gcggcgccga gacgccggac
1239601 gtcgccccgg tgatcctggt cgacacttcg gtatggattg agcacctgcg cgccgccgac
1239661 gcgcgactcg tcgagctgct gggcgatgac gaggccggtt gccatccgct cgtcatcgag
1239721 gagctggcgc ttggctcgat caagcagcga gacgttgttc tcgatctgtt ggccaacctc
1239781 taccagtttc cggtggtgac ccacgacgaa gtgttgcggc ttgtcggtcg gcggcggttg
1239841 tggggtcggg gactcggtgc cgtcgatgcc aaccttcttg gttcggtggc tctggttggc
1239901 ggcgcgcgac tatggacgcg ggacaagcgg ttgaaggcgg cgtgcgcgga aagcggtgtt
1239961 gcgctggctg aggaagtgtc ctgagttgta taccgtcagc gttgctggga gtaatcgacc
1240021 cggtgccgcg tggcgcatgt tcggccatgt tcattgcccg atttggcgcg atagcgtgat
1240081 ttatgttgat ttgttacatt cgcactgaac ccttccgtat ctatttttat attgttgcgt
1240141 gacatatccg ctgtacgcgt gggacgggcc attatttgga taatgcgtga taagcaccac
1240201 aagaattgat ttcctatgga tattgtcggt agcgttcgcg tccatgattg ctcttgcaac
1240261 gctgttgacg cttatcaatc aagtcgtcgg cactccgtat attcccggtg gcgattctcc
1240321 cgccgggacc gactgctcgg agctggcttc gtgggtatcg aatgcggcga cggccaggcc
1240381 ggttttcgga gataggttca acaccggcaa cgaggaagcc gccttggcgg ctcggggctt
1240441 tcaacaggga accgccccca atgccttggt gatcggttgg aatggccacc acacggcggt
1240501 gacgctgccc gatggcacgc ccgtatccag tggtgaaggc ggtggcgtgc gggtcggtgg
1240561 cggtggcgcc taccagccca aattcaccca ccacatgtat ctgccgatgg atgtggacgc
1240621 gggagaagac cagccgccgg cgccagatga gccggtcacc gcggtcgacg acgtggaacc
1240681 ggaaatgcct gcaccgtgcc cgacccagcg cccgccggtg accccgagac ataacctgtg
1240741 caacaaactc cggactatgc caggggcgct ctcggccgcg ctggccgcgg cggcgccggt
1240801 ctggccggcc cctataagcg gctgccgcgg gttcagcacg tccctcttag caaaaagaaa
1240861 tcacccagta atcgtcggga aatagagtgt acccaaacca atccttccgt ggcggaaata
1240921 ttcttggcgc ttctccaacg ccttcgccaa atcgttgtcc acggaacgat ttcacttatg
1240981 caagcacggc gctgccatac ggatgtgtag tcgaatggcc gacgaaccgc gcttagaagc
1241041 cggcgcgcac cccttcgaag agggccggga caaggccccc gaacttcgtg ccactcagat
1241101 ggaccatgtc cggttcaccg aaggtcggcg tgaacgtaac cgtgaccggc tcgagcggag
1241161 ccagcagttc cgccaaccgg gtcgctgaca gcgaccaact cgtatccgta ctccggtgac
1241221 acgtcaatcg actgcgatat cgacgtctgg ccgaacaaga aaccgttgac ggcgttgccc
1241281 ggagcctgca gaaccgcacc ggtggccccc aacaggttcc cgctatgcag cgcaccgaca
1241341 aatgccgtgt tgctgtcctg caaccccctg accgtgccca gggcacccat acgtcatcgt
1241401 cgagcacaca gcgtagccgc cgggcgctcc ggctctgggt gaaatgacgc tggggcctca
1241461 aggccagcac cggttaccca cttctcggcc ccgggagcgc accatgcgca cggcgatgtc
1241521 gccccgtcag gcatgtgccc aaaccgtgga caacgcacgt tgtcaccgtt tatcgtgagc
1241581 gcaaagtggg agtatggagt gtacgtgccc ggcccgggta ccctgagcgg caatgatctt
1241641 catcgtcgtc aagttcgaga ccaaacccga gtggaccgag cgctggccgg atttggtcgc
1241701 atcgttcacc gcggccacgc gtgccgaaga gggcaaccta tggttcgagt ggtcccgcag
1241761 cctcgacgac ccggccgagt acgtcctggt cgaatccttc cgtgacggcg aggccggcgg
1241821 cgtacacgtc aacagcgatc acttcaggca ggccatgcgg gaactgccga aggcactggc
1241881 gtccaccccc aagatcatca gccaaaccat cgatgcgacg ggttggtcgg cgatggggga
1241941 gatgacggtc gggtaaccgg cgaggcccga tcagccgccc acgtcgaccg cgatttcgtg
1242001 acccagccga taacccggcg ccaggggcag cgagtcaccg ctccagaact tgccggggtc
1242061 gaaccagtgc gcgtccttgt cggtgaccag caatcccatt tcctcatagg tgatggccac
1242121 cgtctccgcg caatatgccg tcgccaggcc catcgtgcgc tgctgttgct tacgtcgctg
1242181 ggtttgttcg cgcaccttgc ggtccagcac cggtatgccg cgcagccaat cgttgagggt
1242241 cggaagccgg ccgcgcagcc accggccggt caaccgggcg gtggttggga aaggcgtgcc
1242301 gttcatccgc gcgatgaccc gcagcagttt gtcctcctgg tcgcgattgg cgtgcggtgt
1242361 cagttgacgc agccagcacc gctgccgata acggccggcc cactgctgca cgacttggcg
1242421 ggcgtcgttg agctgcacgc cgcggtggtt ggtgccggtc catacgtcga gcagcttgtc
1242481 gcccagttcg gcatgccaga tcagcggcgg caagtcgtcg atggccaccg tcatgccgac
1242541 gtggttcacc ggggcgttcg tcaaggtctg gatcgcccgg tcgggtcggg aacggccgcg
1242601 aaacagccag aggtcgccgg tgcgggtttc gttcagcgct cgatccagcg ctagcgtgct
1242661 cgggtccacc ccatgcacca taggcggata tagcctgtcg gggtgcgcaa cgtgtggaag
1242721 tgggtcgggc tggccggtgt cgccggcgtc gtcgcgggtg gcgccctggt ggcgcgcgat
1242781 caacggaaac gacgtgccta cacgcccgac gaggtgcggg cccgattgca ccagaggctg
1242841 gacgaatccg acgtcgacgg ttatcagtcc aggtccggcc cgggtgccgc gtcgagcgag
1242901 aacaggcgat agctgccgaa acggatatcg gcacagtcgc tgacggcgtc gtgcaccggt
1242961 tcgcctacca ggatctggcc gccgaccgct tgccccgcaa cccgagcggt cattgcgacg
1243021 ttgcggccga acagatcgtc accgtgccgc accgagcgcc ccatgtggtg ccgatccgca
1243081 cccgaattcc ctggttccgc ttacgctttg cgctgttgcg cagcgcgtcc tggatgtcga
1243141 tgccgcaccg caccgcctgt tcggcgcggg cgaacgcgat catgaacccg tcaccctgac
1243201 tcgtgaccat gtgcccggac cagcgccgca ccagctcatg aaccagcttg tcatgcgcgc
1243261 caatcaactt gacccatgtg cgatccccga ttcgttcgtc gagcgcggtg gactcctcga
1243321 tgtcggagaa caggatcacc acccggccgt ccggggttac ccgagccagg tcgggacgct
1243381 ctacctcggc ccagtcggcg gggtcctcga tcgagctgcg cacggccgct ccgaaccctt
1243441 ctttgcgcac caggttcgcg gtctgccaga ccgtctttac cgcttcacga ccacccgaca
1243501 gcattgcggg cgtcgagccg ctcccgcggt tgctcggttt cctggcgtat ccgcctcagc
1243561 cggatgcgca tcgggacgag tccgccggcc tcgatcgtgg cgatcccggc caggatgtag
1243621 accgcgatct gcagcgtcgg gttgtcgggc caatgggcta gggttgagtt cggccgccgc
1243681 gggaaagcaa gtctggaggt gcgggtttgg ttgacggcgg aggtggcgcg tcagatctgt
1243741 tggtgatctt cggaattacc ggtgacctgg cccgcaagat gaccttccgc gcgttgtatc
1243801 ggctcgagcg ccaccagttg ctggactgcc ccatcctggg tgtggccagt gacgacatgt
1243861 ccgtcgggca gttggtcaag tgggctcgcg agtccatcgg tcgtaccgaa aagatcgacg
1243921 atgcggtgtt cgaccggttg gcgggccggt tgtcctacct gcacggtgac gtcaccgaca
1243981 gccagctcta cgattcgctg gccgaactga ttggctcggc ctgtcggccg ctgtattacc
1244041 tggaaatgcc gccggcgctg ttcgcgccga ttgtcgaaaa tctcgcgaac gtgcggctgt
1244101 tggagcgcgc acgcgttgcc gtggaaaagc cgttcggcca cgacctggcc tccgcgctcg
1244161 aactcaacgc ccggctgcga gcggtgttgg gcgaagacca aatcctgcgt gtggaccact
1244221 ttctgggcaa gcagcccgtc gtcgagctgg agtacctgag gttcgccaat caggcgttag
1244281 ccgagctctg ggatcgcaac agcatctccg agatccacat caccatggcc gaggacttcg
1244341 gggtggagga ccgcggcaag ttttacgacg ccgtcggtgc cctgcgtgac gtcgtgcaaa
1244401 accatctgct gcaggtgctg gcgctggtga cgatggaacc gccggtcggt tccagcgccg
1244461 atgacctcaa cgacaagaag gccgaggtct tccgggcgat ggcgccgctg gatcccgatc
1244521 ggtgcgtgcg tgggcagtac ctcggctaca ccgaagttgc gggcgtagca agcgattcgg
1244581 cgaccgaaac gtatgtcgcg ctgcgaaccg agatcgacaa ctggcgctgg gccggggtgc
1244641 cgatcttcgt gcgggccgga aaagagctgc ccgcgaaggt caccgaagta cggctatttc
1244701 tacgccgagt tccggcattg gcctttctgc ccaaccgccg accggccgag cccaaccaga
1244761 ttgtgctgcg tatcgacccc gatccgggta tgcgactgca gatttcggcc cacaccgacg
1244821 actcgtggcg agatatccac ctggactcct cgttcgcggt ggacctcggt gaaccgatac
1244881 gaccctatga gcggctgctg tatgccggat tggtcggcga tcaccagttg ttcgcccgcg
1244941 aggacagcat cgagcagacg tggcggatcg tgcagccgct gctcgacaac ccgggtgaaa
1245001 tccatcggta cgatcgcggt tcctggggtc cggaagccgc gcagtcgttg ctgcgcggtc
1245061 accgcggttg gcagtcgccg tggctgcccc gcggcacgga cgcatgagtt caaggagacg
1245121 aaaaggcgat gcaactagga atgatcggtc tgggccggat gggtgcgaat atcgtccgcc
1245181 gcttggccaa aggtggacac gactgcgtgg tctacgacca cgaccccgac gcggtcaagg
1245241 cgatggccgg ggaggaccgg accaccgggg tggcctcgtt gcgtgagttg tctcagcggc
1245301 tctccgcccc gcgagttgtc tgggtgatgg tgcccgcggg gaacatcacc accgcggtga
1245361 tcgaagagct ggccaacacg ctcgaggccg gcgacattgt gatcgacggt ggcaacacct
1245421 attatcgcga cgatctgcgg cacgaaaagc tgttgttcaa gaagggaatt cacctactcg
1245481 actgtggcac cagcggcggt gtgtggggtc gggaacgtgg ctactgcctg atgatcggcg
1245541 gggatggcga cgcgttcgcg cgcgcggagc cgatcttcgc caccgtcgcg ccgggggtgg
1245601 cggccgcccc gcgcaccccg ggccgagacg gtgaggtcgc gccatcggaa caaggctatt
1245661 tgcattgtgg gccttgcggt tcgggtcact tcgtgaagat ggtccacaac ggcatcgaat
1245721 acgggatgat ggcctccttg gcggagggat tgaacatcct gcgcaatgcc gacgtcggca
1245781 cccgcgtgca acacggtgac gccgaaaccg cgccgctgcc gaatcccgag tgctaccagt
1245841 acgacttcga catcccggag gtcgccgagg tatggcggcg gggcagcgtg atcggctcct
1245901 ggctgctgga tttgaccgcg atcgcgctgc gcgaatcacc tgacctagcg gaattctccg
1245961 gacgggtctc cgactctggc gagggccggt ggaccgccat cgcggcgatc gacgagggcg
1246021 tgcccgcgcc ggtgctgacc accgcgctgc agtcccgctt cgcctcgcgt gacctcgacg
1246081 acttcgccaa caaggcgctg tcggcgatgc gcaagcagtt cggcggacac gccgagaaac
1246141 cggctaacta agtcgcctga cgaagtccac cacgacgtcg gtgaacgcgt cgttgtcgtc
1246201 gccggcggcg gtgcgccccg cgttggacaa ttcgacgaac tccgcgttgg gcaccttggc
1246261 caggaagtcc cgggcaccgt cggaactgac cacgtcggac agctttccgc gaatcaacag
1246321 gaccgggatc gtcaggccca tggcagcccg ttcgaagttc tcggtgcgca gctgcgggtc
1246381 gtgccccggc gcggtcatca tggccggatc ccagtgccag tgccagcgtc cgtctcgcag
1246441 gcgcagattc ctcttcaggc cctcgggact gcgcggcttg tcgcggtgcg gcagatactc
1246501 ggcgactgcg tcggcggctt cctcgagcga accgaagccg tcgatgttgc ccagcatgaa
1246561 gtcccggata cgggcgttgc cctccttctc gtaacgcggc accacgtcga ccaataccag
1246621 tccgttcacc gtctgcggac cggcgcgctc ggcgaccagg atgccagtca gtccgcccat
1246681 gctggcctcg accaccacca cacggcggcc gatcgcctcg acgacgtgta gcacatcggt
1246741 ggtcggggtc tccacggcat agtcggcgcc gggagcgcgg tcgctgtcac cgggtccgcg
1246801 ggtgtccagc gcaacgacgt ggtgcccctc gtcggccagg atctggccgg tgtttttcca
1246861 ggaaaaccgg ttttggccgc caccgtgcaa catcaggatc gtcggccgat cggccgctgc
1246921 ggcgccccga ttccactcgt cggcgaccag ggtaatccca cgagcaccgg aaaacgcgac
1246981 cgcttgggga ctgctgctca cggcgctcac gggtcctgac gttaccttgc tgggcacgcg
1247041 ccaaatcgtc atcgccgacc tggaggatgc ggtgatcaag gtgccctagc tactggcctc
1247101 ttgggttccg ccggttacgt tggaccatgc gggctggacg cggcgaacgg gagtcaacat
1247161 ggcggacgac aatggctgaa ccacactgga ttgacgtgaa gggtcccaac ggcgacctga
1247221 aagccttgac ctgggggccg gccggcgcgc cagttgcgtt gtgcttgcac ggctttccgg
1247281 ataccgccta cgggtggcgc aaggtcgcac cccggctggc cgagtccggc tggcacgtcg
1247341 tggcgccgtt catgcgtggt tatgcgccgt cttcgattcc ggccgacggc agctatcacg
1247401 tcggtgcgtt gatgcacgac gccctgcggg tgcgctcggc tgccggtggc accgagcgcg
1247461 atgtgatcat cggccacgac tggggcgcga tcgccgctac cggcctggcc gccatgcccg
1247521 acagcccgtt tgccaaggcg gtgatcatgt cggtgccgcc gtcggcggca tttcgcccgc
1247581 tgggccgggt gcccgagcgt ggccggttgc tgcgtgagtt gccgcatcag ctgctgcgca
1247641 gctggtacat cctgtacttc cagttgccct ggctgccgga gcgatccgcc tcctgggtgg
1247701 tgccgctgct gtggcggcgt tggtcgccgg gctatcacgc cgaggaagac ctgcggcatg
1247761 tcgacgccgc gatcgggacg ccggagggcc ggcgggcggc cttgggaccg tatcgcgcca
1247821 ccatgcgcaa cacccgggcc ccggcggact atgccgactt gaatcggctg tggaccgagg
1247881 cgccgaagct gccggttctg tacctgcatg gccacgacga tggctgtgcc acatcggcat
1247941 tcactcattg gacggcaagg gtgttgcccg ccggcagtga ggtggccgta gtggaacacg
1248001 ccgggcactt cttgcagctc gagcagccgg acaagattgc agagttgatc gtggcgttca
1248061 ttggctcacc cggctgaagt cgtggccggg caccggatgg cggccgtcga cgcgcagttc
1248121 tactggatgt cggccaaagt ccccaacgac cagttcctgc tgtatgcgtt cgatggtgaa
1248181 cccaccgatc tggaacgtgc cgtcgcgcag gtctaccgtc gagcccgtgg gtgtccgggc
1248241 ttagggatgc gagttcagga ccgtggtgct ctggcctacc cgcagtgggt gcccacaccc
1248301 gtgcaacgtg accaactggt ctgccacgac ctggccgatc gcagctggca aggttgtctg
1248361 gcggccgttg tcggcctcgc cagcaagcag ctggatatgc gccggatgcc ctggcggctg
1248421 cacgtgttca ccccggtgca cgacgttccg ggcgtcagcg gcctcggcac cgtcgccgtc
1248481 atgcagttcg cgcatgcgct gggcgacggc gcgcgggctt cggcgatggc cgcgtggctg
1248541 ttcggccggc cggccgcggt tcccgaaata gccaggtcgc gtgcgggttt cctgccgtgg
1248601 cgggccgccc atgcggcccg cgctcatctc cgactggttc gtgataccaa tgccgggctg
1248661 gtagcgccag gtgtcggatc ccggccgccg ctgtccacga atgcccgccc cgaaggtgtc
1248721 cgcgcggtgc gcaccctgct gcggcggcgc tcgcaactag ccggtcccac ggtgaccgtc
1248781 acggtgctcg ccgcggtgtc caccgggctg ttgggtctgc ttggcgggga tgtggacacg
1248841 ctaggcgccg aagtacccat ggccaaaccg ggtgtgccac ggtcatataa ccacttcggc
1248901 aacgttgtcg ttgggctgta cccgcggctg gagccggatg agcgggtgcg gcggatcgca
1248961 accgatttgg ccaacgctcg ccgtcgcttt gaacatccgg cgatgctctc cgctgaccgg
1249021 gcctttgcgg cggtaccggc ggcgctgctg cgttggggcg tatcgcagtt cgacgctgag
1249081 gtgcggccgg tgcgggtggc cggcaatacc gtggtgtcca gtgtttatcg cggggctgcc
1249141 gatctgagct tcggggacgc tccggtggtg ctgacggccg ggtatccggc gctgtcgccg
1249201 gcgatgggtc taacccatgg cgtgcacggc atcggtgata ccgtcgcgat cagtgtgcac
1249261 gcggccgagt ctgcggtgtc tgacatcgac gcctacatgc ggctgctgga cgcggctctg
1249321 cagtgaaaac tactgggcat caccggattt agccgcttcg tctcgtgtca gcccgacggc
1249381 ctggatcagc tcctcgtgta gttcgaacca cacggtgtgg taggagtcga tgagtgggcg
1249441 cgtcagccag gcgatgtcgc ccgctttgac cttgtccagc gccgcacgca atttcaccgg
1249501 gtacctgctc aaccgcggca gctgcatggc caccgtaccg atgatcgggc ccacccgccg
1249561 gtgtacgcca tcgaggcggg acagcaccgc ggcgtcgtat tcggcgtcgt cgtgtgtgtt
1249621 aggcttttcg cccttgagct gccagtcggt gaccagcctc ttgaaatcgg cgttgacgga
1249681 acggaaatcg cggtaagcgg cagccagcac ggtcgaatcg gcccggttgc gctcctcggc
1249741 aagcaagtcg tcgagcctca tccggccgct gggactgatc cgcaacggcg tggcgtcgac
1249801 caggaggccg gccgcggtca gcctgtcgac ggtcgcggcg acgtcggcaa ggtcttcacc
1249861 caaggtctgc gccaggtcgg tggtgatcac ccggcccttg agccgcacgg cctgcagtac
1249921 cgtcaactcg ctcatgaact gatccgttgc gcgatgtcgg ccagctcgcg caactccggc
1249981 gtgtcacttt ccgaccaggc agacaatgcc agaacgcctt ggcgcacttc gccttcatag
1250041 ccgtcgacgg tgatctcctt gccggccagt gccgccgcga ccccgggacc gcaacccacc
1250101 acggccactc gaccgagctc gcggctaacc accgccgcat gactggcggc accccccacc
1250161 tcggtgacaa tgccttgcgc ggcaagcatg cccatgacgt cctccggtct ggtgtgatct
1250221 cgcaccaaga tgaccggctc gccccggtcc gcagcgtcca gcgcctcgtc cacctcggtg
1250281 taggcggtcc cggataccac gcccgggcaa gcgggcaggc ccttggccaa aagcggtgca
1250341 gccaaccgtg tttccgtctg cagcgacggc cgtagcaaag tctcgatgtg cgtcggagtc
1250401 acccggcgca gtgtctcggt gtcgtcgatg agtccctcgt gatgcagttg cagcgccagt
1250461 cgcacggcgg cctgcgccga gcgttccgcc ccgcgggtct gcagcagcca cagctggctg
1250521 tcctccacgg tgaattcgat ctcctggacg tcgcctgcca tgcgctccaa actgcgggcg
1250581 gccgccatca gttggtcgta gacggccggc tgctggtcgc gcagggcggt gatcggtgcg
1250641 acggcgacca atccggacac cacgtcgtcg ccttggccgc cgggtagcca ttcgccgaac
1250701 ggttcgttgg ctccggtgat cgggttgcgt gaggacagca ccccggcgcc cgagttcgcg
1250761 gtgaggttgc cgaataccat cgcctgcacc accaccgccg taccgccttg gtcgtcgagg
1250821 ccgtgatggt cgcgataggc aacggcgcga ggtgagttcc aggaggcgaa taccgcctcg
1250881 atgctcgcgc gcaactgggc atacgggtcg tcggtaatgg gaccggcgct gccgacgatg
1250941 cgccgataca tgctggtgaa tcgccgtctg gtgtcgtggg cgaagtcggc ggcacccggc
1251001 ctggcaagta ctcgttcgac cgcgtcggtc atgcccacgt ccagaatcgt gtccatcatg
1251061 ccgggcatcg actgggtggc tcccgagcgc acgctgacca gcagcggatt cgggccacgg
1251121 ccgaacgtgc acgaggtttc tgtttccagc cagctcatcc gatccagcac gtcatcccag
1251181 atcgcggcga tcgtggatcc gggcgcggcg agatagcgca cgcccacctc ggtggtaatg
1251241 cagaatgcag gcggcaccgg cagatggtgc cggcgcatca tgtcgatgcc gtggcctttg
1251301 ttgcccagga tctcgcgtgg gtagttcgcg ccgccgtcca gcgccacaac ggcgttttcg
1251361 agagttccgt cggggcaacc attggctcgg gtgatacgag tcatgggcac cccttgatgc
1251421 tacttatggg caacgccaga ccgcccactg tgggcccaca gggggcgcct tggtcagcgg
1251481 tcggactact cagcttgtgt ctggtgttgg gccttaccca tgctgcgaga caacgccggc
1251541 tgccggtgat ggtggctggc ggcgtggaca gcgcaccggc ccaacggctt ggttcgaccg
1251601 gctcccccgc ctaacgctac gggtcgcctt cgtcgtctgc caggagcttt tccgggtgat
1251661 ggaacgtatt gactcgaggt tggccgtggt cgagatgtgg cggcggtagc cactcggtgt
1251721 cgccgtgggc gttcttgcgg gtcgtccagc cacgttcggc taacggatga tggccaccgc
1251781 agccgagtgt caggtcattg acgtcggtgt tgcggcactg ggcgtacggc gtgacatgat
1251841 ggacttcaca gtaatagccg ggcacgtcgc aaccaggtgc gctgcagcca ctgtccttgg
1251901 cgtacaacat aattcgctgc gccggggagg ccaggcgctt ggtgtggtag agcgccaggg
1251961 ccttgcctcg atcgaatatc gcgaggtagt ggtttgcgtg gcgggccagc cggatcacat
1252021 ccgatatggg caagatcgta cccccgccgg tgaggcccgc gccggccgcg gcctccaagt
1252081 ccttcagcgt ggtggtcacg atgatgctgg ccggtaatcc gttgtgctgg cccagattgc
1252141 cacttgtcaa caaactacgt aattcggcgt tgagcgcgtc gtggttccgc tgtgggcagc
1252201 tgcgggtgtc tcgccgcgcc tgctccttcg agggcgcgcc gttcacacac ggtgccttct
1252261 gctcggggtt gcacataccc ggggcggcca gcttggccca caccgcctcg atagtggcgc
1252321 gcagctcggg ggtcacatat ccgctgagcc gcgacatccc atcgacatct tgctttccta
1252381 acgtcaagcc gcggcggcgg gcgcggtcct cgtcggtgta gtcgccatcg gggttgaggc
1252441 agtccatgat ccgcgcggcc aatttggcca gctggtcggg acggtactgg gtggcctgct
1252501 tagccaagtc ccgttcggcc ttctccaggg tcttgaggtc tacccaggat ggtaggcggt
1252561 gcacgaaagc acggattact tcaacatggc cgtcaccaat taacccgtgg cgctgtgcct
1252621 ttgcggtggc ggtgagtagc ggtggcagcg gctcgccggt cagcgcacgg cgctggccaa
1252681 ggtcggcggc ctcggccact cgccgcttgg cctcgctgcg ggtgatgcgc aaccggtcgg
1252741 ccagcgtcaa tcccagcttg ccgcccagct cctcctcggt ggattgttcg ccgatctgat
1252801 tgatcaacgt gtgttcgacg ctgggcagct ggcgtcgcgc ggtctcgcag tgctccagca
1252861 gcgccaggcg ctccggggtg gtcaatgcgt caaaggtcag ccccagcacg cgggacagcg
1252921 cggtagccaa tgacgcgaag gcctccgtga tctcctcccg agtggaacac atgactgaat
1252981 gctatgtgca ggcaccgaca acaatgcttg cccagagcct gctgaaacca cagtaatata
1253041 aggggtttcg ttgtctgctg tggcgtcggg cggtcaaacc gattgctcgg tcgacgaata
1253101 aggcaagctg ctgcccgcgt tctcgtcgac cgcgacgcga ccaccgagat aggggaacgc
1253161 acgttgggcg cacgacgttc ggttgcagat cttgcagccc gccccgatcg ggacctccgt
1253221 gctcgggtcg tccaggacga caccggtgga gtagacgagt ttatgggcgt gcgcgaggtc
1253281 gcagcccagc ccgaccgcga agttcttgtg cgggcccaga tacccgagcc cgtcggcagc
1253341 ggtggtcttg gccacccaga agtacgacct gccgtcgggc atttgcgcca cctggcggac
1253401 gatcctctct ggctgggcga acgcgtcgtg gaccacccac agcgggcagc tgccgccgac
1253461 ccggctgaag tgaaacgccg tcgcggactg tcgctttgag atgtttccgg ccttgtcggt
1253521 gcggacgaag atgaacggta tccctcgctg ccgcgggcgc tgcagtgtgg agagccggtg
1253581 gcagacggtt tcgaagccca ctccgaaccg gcggcccagc aggtcgatgt catagcgtaa
1253641 ctgctctgcg gcacggtgga attcgcggta ggggagcagg aaggcgccgg cgaagtagtt
1253701 ggccagtccg atgcgcgcga cgccgcgggc ttcggtgctg agctggtcat cggtggccac
1253761 gatcgacgag atcaggtctg actggcccac cagcgccagt tgggtggcga tctggaaggc
1253821 gcgctgtccg ggcatcagcc agtgggcgac ccgaaggacc ttggtgtcgg ggtggtagcg
1253881 gcgcttggcg gtgtcgggca gattgtcatc gatcaccacc gagatgccga accggtcccg
1253941 catcagctcg gccagctgga tgtccaatcc gccggtccgc atcccgcttt cggtaaacat
1254001 ccgctccgcc gccatgtcca ggtcgtggat gtagttgttg cggtcgtaga agaagtcgcg
1254061 gacctcctcg aacggcatcg gccgcgcggg cggtagctcg gtttcggcgg tcgcacgaga
1254121 tcggtagccc tctagttcct cggtggcggc gcgcaaccgg cggtgcacgg caaccaggct
1254181 gtggccgacc tcgggcatcc gggcgacgaa ttcttcgatc tgggcgccgc tgaccgcgtg
1254241 ctcgacgccg atgtcggtga agacgtcgga caggtcggcc accaaccgtg cgtcggaatc
1254301 cgaggagaaa tactgcgccg acaggtcaaa ccgctcggta agcagaagca gcacgggcac
1254361 ggtgatgggc cgctggtcat tctccaactg gttgacatag cttgtggata agtccagggc
1254421 cttggccagc gccacctggg tgagcccgcg ctcttgacgt aaccgccgca ggcgggcacc
1254481 ggaaaacgtc ctcgaatacg tcctagccac cggtaagaca ttactccgcg tcatgttcgc
1254541 aaaatttgca aaatgtgccg gatcaggaca caaaagtacg ctttttcagg gtcttttgtt
1254601 ggtgtcctgt gctgcgtatg gtgcggatta tgttgatgca tgcggtccgg gcgtggcgca
1254661 gcgccgacga tttcccgtgc accgagcaca tggcctacaa gatcgcccag gtggctgccg
1254721 atccggttga cgtcgacccg gaggtagcgg acatggtgtg caaccgcatc atcgacaacg
1254781 ctgcggtgag cgccgcatca atggtgcgca gaccggtcac cgtggcccgc caccaggcac
1254841 tggcgcatcc ggtgcgacac ggggcgaagg tatttggcgt cgagggcagc tactcggcgg
1254901 actgggcggc ctgggccaac ggcgtcgccg cgcgtgaact tgactttcac gacacgtttc
1254961 tggccgccga ctattcgcac ccggcggaca acataccccc actggtggcg gtcgcccagc
1255021 agctcggcgt gtgcggcgcg gagctgatcc gcggtctggt aaccgcctat gagatccaca
1255081 tcgacctaac ccgcggaatc tgcttgcacg agcacaagat cgaccatgtc gcccacctgg
1255141 gcccggcggt ggccgccggc atcgggacca tgctgcggct cgaccaagag accatctacc
1255201 acgcgatcgg ccaggccctg catctgacca ccagcacccg tcaatcccgc aagggcgcca
1255261 tctccagctg gaaggcgttc gcgccggcgc atgccggcaa ggtcggcatc gaggcggtcg
1255321 atcgggcgat gcgcggcgag ggctcaccgg ctccgatctg ggagggcgag gacggggtga
1255381 tcgcctggct gctggccgga cccgagcaca cctaccgggt gccgttgccc gcacctggtg
1255441 aacccaagcg cgccattctg gacagctaca ccaagcaaca ctccgcggag taccagagcc
1255501 aggcgccgat cgacctggcc tgccggctac gtgagcgtat cggcgatctc gaccagatcg
1255561 cgtcgatcgt gctgcacacc agccaccaca cccatgtagt gatcggaacg ggatccggcg
1255621 atccgcagaa gttcgacccg gacgcgtcac gcgaaaccct cgaccactcg ctgccctaca
1255681 tcttcgccgt ggcactgcag gacggctgct ggcaccacga gcgctcctac gcgcccgagc
1255741 gggcgcgccg ttccgacacg gtggcactgt ggcacaagat ttccaccgtc gaggatcccg
1255801 agtggacccg ccgctatcac tgcgccgatc cggccaaaaa ggcgttcggg gcgcgcgcgg
1255861 aggtgacgct gcacagcggt gaagtgatcg tggacgaact ggcggtggcc gacgcccatc
1255921 cgctgggcac ccggccgttc gagcgcaagc agtacgtaga gaagttcacc gagctcgccg
1255981 atggtgtagt ggaacccgtt gaacagcaac ggttcctggc cgtagtagag agtctcgccg
1256041 atctcgagag cggtgccgtg ggtgggctga acgtgttggt cgatccgcgg gtgctggaca
1256101 aagcgccggt gattccacca ggaatctttc gatgaccggg ccgctcgcgg cggccaggtc
1256161 cgtcgctgcc acgaaatcga tgaccgcgcc caccgttgat gagcggcccg acatcaaaaa
1256221 gggcctcgcc ggcgtggtgg tggacaccac cgccatctcc aaggtggtgc cgcagaccaa
1256281 ttcgttgacc taccggggat atccggtcca ggatctggca gcccgctgca gtttcgagca
1256341 ggtcgccttc ctgctgtggc gtggtgagtt gcccaccgat gccgagctgg cgttgttcag
1256401 ccagcgcgaa cgagccagcc gtcgggtgga ccgctcgatg ctgtcattgc tggccaagct
1256461 gccggacaac tgccacccga tggacgtggt gcgcaccgcg atcagctatc tcggtgccga
1256521 ggacccggac gaggacgacg ccgcggccaa ccgggccaag gcgatgcgca tgatggcggt
1256581 gttgccgacg atcgtggcga tcgacatgcg gcgccgacgc gggttgcccc cgatcgcacc
1256641 gcacagcggg ctcggttatg cgcagaactt cctgcacatg tgcttcgggg aggtacccga
1256701 aaccgccgtc gtgtcggcgt tcgagcagtc gatgatcctc tacgccgagc acggattcaa
1256761 cgcgtcgacg ttcgccgccc gggtggtgac ctcgacccaa tccgacatct acagcgcggt
1256821 gaccggcgcg atcggcgccc tcaaggggcg gctacacggc ggcgccaacg aagccgtcat
1256881 gcacgacatg atcgagatcg gcgatccggc caacgcgcgg gagtggttgc gcgccaagct
1256941 cgcccgcaag gaaaagatca tgggcttcgg gcatcgggtg taccggcacg gcgactcccg
1257001 ggtgccgacc atgaaacggg cgctggagcg cgtggggacc gttcgcgacg gccagcgatg
1257061 gctggacatc taccaggtgt tagcggccga gatggcgtcg gccaccggga tcttgcccaa
1257121 cctcgatttt ccgaccgggc ccgcgtacta cctgatggga ttcgacatcg ccagcttcac
1257181 cccgatcttc gtgatgagta ggatcaccgg ctggaccgca cacatcatgg aacaggccac
1257241 ggccaacgcg ctgatccggc cgctgagcgc atattgcggg cacgagcagc gggtgttacc
1257301 gggcaccttc tagtcttatg ggccatggga tttctccagc cccgacttcc cgacatcgac
1257361 ctggccgaat ggagccaggg ctcccgcagc cagaagatcc ggccgatggc ccagcattgg
1257421 gccgaggtgg gttttggcac tccggtgctg ctgcacctgt tttacgtcgc caagatcctg
1257481 ttgtacgtcc ttgtcggctg gctgatcgtg ttgaccacca aggggattga tggattcacc
1257541 gatgcggcag cgtggtacgc cgagccgatc gtgttcgaga aggtcgtgct ctacaccatg
1257601 ctgttcgagg tgatagggct gggctgcggc tttgggccgc tgaacaaccg attcttcccg
1257661 ccgatgggct cgatcctgta ctggatgagg ttcggcacca tccggctgcc gccgtggccg
1257721 gatcgagtgc cgtggacccg cggcaccaag cgcaagccgg tggacgttgc cctctacgca
1257781 ctgctggtga tgatgttgct gtcggcgctg ttcaccgatg gcgccggccc cataccggag
1257841 ctgggcacca cggtcgggct gctgcccgcc tggcagatcg tgctgatcct gctgcttctc
1257901 ggtgtgctgg gcctgcgcga caaggtgatc ttcctggccg cccgcggcga ggtctacgcg
1257961 acgctgacgg tgacgttttt gttcggccgc ttgaacggta tagacatgat cgtggccgcc
1258021 aaactggtgt tcctggtgat ctggatcggt gcggcgacat cgaaactcaa ccggcacttc
1258081 ccttttgtga tctccacgat gatgtccaac aacccgctgt ttcggccgcg gttcatcaag
1258141 cggatgtttt tcaagaagtt ccccggcgac ctgcggcccg ggctgttgtc gcggattgtc
1258201 gcccacgtca gcactgttat cgagatgtgt gtgcccgtgg tgttgttcgt tgcgcacggc
1258261 ggctggccga cggtggtggc cgcgacgatc atggtctgct ttcacctggg gattctgacg
1258321 gccatcccga tgggggtgcc gctggagtgg aacgtgttca tgatcttcgg cgtcctgtcg
1258381 ctgttcgtcg gccacgcctg cctcgggtta gcggacgtga aaaacccggt gccgctggcg
1258441 atcctgatcg ccgttgtcgc gggaatcgtc attgcgggca acgtgtttcc ccgcaagatc
1258501 tcgtttctag ccgccatgcg ctattacgcc ggcaactggg ataccacgct gtggtgcatc
1258561 aagccctccg cggaggacaa gatcaaccgg ggcatcgtcg cgatcgccag catgccggcc
1258621 gctcagctgg agcgcttcta cggcaaggac cgagcccaga tcccgatgta tctgggatac
1258681 gcgtttcgtg cgatgaactc ccatggcagg gcgctattta cgctggcgca tcgggcgatg
1258741 gccggccatg acgaagacga ctacgtcatc accgacggcg aacgggtctg cagcactgcc
1258801 gtcggctgga acttcggcga cggccacctg cacaacgagc aactgatcgc ggcgatgcaa
1258861 cagcggtgcg gcttccaacc cggtgaggtg cgggtggtgc tgctcgacgc gcagcccatc
1258921 catcggcaaa cccaggagta ccggttggta gacgcggcga ccggggagtt cgagcgcggc
1258981 tatgtccggg tggccgacat ggtgaaccgg cagccctggg acgacgacgt gccggtccac
1259041 gtgctgccgg gctagctgct cgtcagctag cccgcgcgca cctcccgggc ggcggcgacc
1259101 atgttgtgca gcgacgcggt cacctcgtcg acattgcggg tcttcagtcc gcagtcgggg
1259161 ttgacccaca gccgctcggc cggcaccgcg cgcaacgcgg cccgcaacga gtcggccatc
1259221 tcctcagcgg agggcacccg tggcgagtga atgtcataga cgcccgggcc cacaccgttg
1259281 gcgaagccga tcgcgttcag gtcgtcgagc acctccatgt gtgaccgggc cgcctcgatg
1259341 gacgtgacgt ccgcgtccag atcggcgatc gcgccgatca cctcgccgaa ctccgagtag
1259401 cacagatgcg tgtggatctg ggtggcgtcc gagacgccgg aggtggccaa ccggaaagcc
1259461 cctaccgccc aacgcaagta ctcggcctgg tcggcgcgac gcagcggcag cagttcacgc
1259521 agcgcaggct cgtcgacctg gatgaccgcg atgccggcgg actgcaaatc cacggtctcg
1259581 tcgcgaatcg ccagcgccac ctggttggcg gtatcggcca acggctggtc gtcacgcacg
1259641 aacgaccacg ccagaatcgt caccggcccg gtcaacatgc ccttcaccgg tttgtcggtc
1259701 agcgactgcg cgtaggtgat ccactcgacc gtcatcgccc gcggccggga cacgtcgccg
1259761 tacaggatcg gcggacgcac acagcggctg ccgtaggact gcacccagcc gttctgggta
1259821 gcgaagaaac ccgccaattg ctcggcgaag tactgcacca tgtcgttgcg ctccggttcg
1259881 ccgtgcacca gcacgtcgag cccgagccgc tcctgtagcg cgatcacctc ggtgatctct
1259941 tgccgcatcc ggcgcacgta ctcggcctcg tcgatctcac cggcccgcag cgccgcacgc
1260001 gcaacgcgga tcgccgaggt ctgcgggtag gagccgatcg tcgtggtcgg cagcggcggc
1260061 aggtgcagtc gcgcgtcttg gctggcgcgg cgctgggcgg cattgccgcg gtgggctccg
1260121 gacgcgacga tcgcctcgat gcgcgcccgg atttgcccat tgtgtaaccg cgggtcgcgc
1260181 ttgcgggacg cgatggcggc gcgggacgac gcgatctcgt cggcgaccgc gtcgtgtccg
1260241 tcgcgcaggg cacgcgcgag aacgacgact tcgcgcacct tttcggcacc gaacgccagc
1260301 cagctccgca acgcgtcatc caggtcggtt tccggttcca gcgagtacgg cacgtgcagt
1260361 gtcgagcacg acgtcgagac ggccacggta gccgccgaac ccagcagggt cgccaacgtg
1260421 cccaacgccg cctccaggtc ggtgcgccag acgttgcgcc cgtcgacgac cccggccacc
1260481 agcgtcttgc cggccagctc gggtaccccg gccaccgagg tgtcggcacc ggccaccagg
1260541 tcgacgccga tggcttcgac cggggtgcga gccagcgccg gtagggccgc gcccgggtcc
1260601 ccgaagtagg tggcgacata gatcgcaggc cggttgctca ccgagcacag cgcggtgtac
1260661 accgcttcag ccagggcggg cgcgtcgggg gagaggtcgg tcaccagcgc cggctcgtcg
1260721 aactgcaccc actgggcgcc gccgtcggca agcagcgaca gcagctccga atagaccgga
1260781 accaactctt cgaggcgttc gatcggcgcc cccgcgccgt cgacggcctt gctcagcagc
1260841 aggaaggtga tcggcccgat gatcaccgga cgtgcgggaa tgccttgccc taacgcctct
1260901 ttgagttcgg cgagcacctt gccggggtgc agcgtgaacg tggtcgacgg cccgatctcg
1260961 ggtaccaggt agtggtagtt ggtgtcgaac cacttcgtca tctccagcgg cgcgatctgg
1261021 tcggtgcccc gcgccgcggc gaaatagcgg tccagcccgt cggaaaccgg gctcactcgg
1261081 ggcggcagcg cgccgagcag caccgcggta tcgagcattt ggtcgtagta ggagaaggtg
1261141 ttcaccggca ccgagtccag accggccgcg gccagggccg accaggtgtc gcggcgtaac
1261201 gtggcggcga cggcctccag ctcggatcgg ctggtacgtc cggcccagta gccttcggtg
1261261 gcgcgcttga gttcgcggcg cgggccgatg cgcggggagc cggtgatggt tgcggtaaag
1261321 ggttgacgac gtacaggctg ggtcacgtgc tgtccttcga tcgacgggtg gttcaccgcc
1261381 cgcggacgcg cagccgatcc gattgaggtg cacaccgatg cacccggcaa caggcacggc
1261441 caaacgccca ttccacgagg cgatgagccg ccgggcgcgg cgcgtccggc acggctggca
1261501 ggtcttcgga ctcgcaggct cgcacccggt gggtgctcct actggccgtc gcttcccagt
1261561 cgttgagacc agtgcttgtc tacttccaag acggcggtcg ttcctgcata ccgctgcggg
1261621 acagtcccgg attctcacca ggttccctct cgcgaagcat cgttgccccg ctcgatgccg
1261681 acgccctttc ggacgccagc agaccagctg cgtggtcaag gctactccgg tgacatcggc
1261741 cggcatggcc cggccggcgg caaaatcgct cggcgccgga tgtcctcatc gggcccgccg
1261801 cgatcgtcat gtgggtgaga ttcgggatag gcccggacca tgatgggtca acaggccgca
1261861 atacgccgca ctcacctgca ccagagacgt cgactggtcg gcccccgagc aggccgctga
1261921 catggccgcc taccagaagt tcgggcagga gcacgccgcc gcgatccgtg gcggcgccgt
1261981 gctgcacccg acggccaccg ccacgacggt ccgggtaacc ggcgcccgcg gcggcgacgt
1262041 cgtcaccggc gacggtccgt acgaggcggc cgacctggac gagcaagggc cattcccgat
1262101 ggagacggtc tacctgtggg aggacggccc gaacggtacg acgaggatga cgctgtaaaa
1262161 ccgtggtgag ccttcccgct tcgcgggaat cgccgcaccc gccatgacgg tggcggtcag
1262221 gcgggccaac gcgaaggatc tcgcgcggcg caggctgctg gaatccgggg gctaaccgtc
1262281 gaagaacccg gactggtcat taccggcgtt gaacccgcct gagctgttgt cgccggagtt
1262341 ggccaccccg gaggtggtgg tgaaggcggc gttggtggcc gagtttccga tgccggtgtt
1262401 gttgaagccg gtgttgaaca ggcccgtgtt aaagccggtt cccgagttgc tgatgcccac
1262461 gtgctggccg ccgccggaat tgagcagacc cgagtgaccg atgaagaagg cgccggtgtt
1262521 ggtgttctgg aagccggagt tcgcgtcgcc ggagttattg aagcccgagt tgccggtgcc
1262581 gatgttgccg aagccggagt tcatcaccgg ttggtccacc gggctgccga acccggtgtt
1262641 caggtctccg gagtggaagc cgccagtgtt gatatcgccc gagttggccc agccggtatt
1262701 gaagtcgccc gagttcaagt ctccggtatt caaggtgccc gagttgaagc tgcccgtgtt
1262761 gtaggcaccc gagttgccga cacccatgtt ctcaaatccc gagttgccga acccgaagtt
1262821 gttgttgcct gcgttcccga aaccgaagtt gccgctgccc gcgttcccga agccggtgtt
1262881 ggtgaagccc gcgttcccga aaccggtgtt ggtgtcaccg gagttgaaga agccgaagtt
1262941 gctgtcgccg gagttgaaga agccgatgtt gttgttgccg gagttgaaca agccgatgtt
1263001 gttgttcccg gagttgccga agccgaggtt gccgatgccg gagttcagtg cgccgatgcc
1263061 gatcatgttg tcgccggtga gcccgatacc gatgttgttg ttgccgagat tcgcaatgcc
1263121 caggttgttg ttgccgagat tcgcaatgcc caggttgttg ttgccgagat tcgcaaagcc
1263181 cacgttggga gagccgtgat ttgcgctgcc cacgttgaag gaaccggcgt tggcggtgcc
1263241 gaagttgaag ctgccgacgt tcccgctgcc ccggttgcca tcgccgatat tccccaggcc
1263301 gaagttaccg ttgccgtcgt tgccgctgcc caggttgagg ttgccgaggt tcccgctacc
1263361 gaagttggtg ttggcggtgt tgccgctgcc aaagttgaag aaaccggtat tgccgctgcc
1263421 caggttggcc tggcccgtgt ttccgctgcc taggtttgcg ttgccggtat tgccgttgcc
1263481 taggttgtag tcgccgatgt tgccgatgct gaagatgttg ccgatgccgg tgttgccgat
1263541 acccaatgcc gggatggcca gggcagcggg gccggaggcc agtgcgggcg ccgtcgggtt
1263601 gggcagggcg cgcaccgcct gtgcccacgg ggccagctgg gcggccaccg ccgaggcccc
1263661 gctgtggtag ctcaccatgg ccgcgacatc ggcggcccac aattgttcgt aggctgcctc
1263721 ggtcgccgcg atcgccgggg cgttttggcc gaacaggttt gatagcacca gcgacaccag
1263781 ctggtggcgg ttggcggcga ccagcagtgg atccacggtg gccgcccgcg cggcttcata
1263841 caccgccgcg gccgccttgg cctgtgcggc cgcgcttagc gcgcgtgttg ctgccgtgct
1263901 tagccagctg gcataggggg ctgccgcggc ggccatcgcc gtcgccgccg gaccttgcca
1263961 ggcggtgtcg gccagcgctg cggtggccga cgaaaacgag ttcgccgctt ggcctaactc
1264021 ggcggccagc ccgtcccagg ccgccgcggc ggccagcgtc gggcctgagc ccgcaccggc
1264081 aaacatcaac gcggaattga cctcgggagg caacaccaga aaactcatca cgccatccct
1264141 tccgcagctg gacgtgcccg ggccatcccc tcccgtgacc acaaacctcc gctggctgaa
1264201 tacgcacagc ccgatcctcc cggcgcgaag cagcgccgcg gtcccgcctg cttgacccca
1264261 gattccatgg cgcgcctccc accaccaaca ctgggccgat cgctcgacac ctcatgcagc
1264321 ttggcaatca aaacactatg agattcgcag ggcggcctca gcgttttcgc caaagcgctt
1264381 accccctgtt caaccccaac agcgcgatcg cgcttggcca cccattcggc ggctcggggg
1264441 cacggttgat gactacagtg ctacaccaca tgccggacaa gggaattcgc tacggcttac
1264501 agacgatgtg cgagggccgc ggccaagcca atgccaccat tgtggagttg ctgtgacagc
1264561 gaccgatagc cagccggcgg cgttgtcgag taccgcgaca atgtcatggt cattacgatc
1264621 aatcggccgg aagcccgcaa tgcggtcaat ggtgccgtca gcatcgtggt tggagacgcg
1264681 ctggaagaag cgcacgacaa ccccgatgtg cgggccgtgg tgatcaccgg cgccggcgac
1264741 aagtcgcttt gcgccggtgc cgacctcaag gcgatcgcac gccgggagaa cccgtaccac
1264801 ccgcatcacg gcgagtgggg catcgccggt tacaggcacc atttcatcga caagccgacc
1264861 agcgccgcgg tcagtggcac ggccttggac gacggtgccg agccagcgct ggccagcgac
1264921 ctggtggtgg ccgacgagca cacctaattc gggtttgccg gaggtcaaac gcgggctgat
1264981 cgccgccgcc gggggtgtac cggtgagccg ctgaccgcat ccgacgactg ggagtggggc
1265041 ctgatcaacc gggtcgtcaa ggagggttcg gtcgtcgagg ccgccctcac ctggccgtgc
1265101 gggtgaccgt caacgcgtcg ctgtcggtgc aggccagcaa gcggatcgcc tgtggtgtcg
1265161 atgacggggt cgtcgtcgac gaagggactc cgcacccagc gcgagatggg ttccctgatg
1265221 agatcgcagg acctcgggcg ttcgccgaga aacaggaacc ggtgtggcgg gcccgctgca
1265281 tcgtctcggc gccttggatg ggcttggcgg gcgtaccgtc agccagcact gtcgcattgc
1265341 caacgtttgt gggacttatc ccgatgccgg ggcgcagtgt cgcgctgagg tgggcacaac
1265401 gagcatcctt cccgggagaa ccaatgtggc ggatgtgaca acgcgccgac aacaccagat
1265461 cctgggctgt ctcagtacgc caggatgttc accccgtacc ggaatgccgt gggcagaagt
1265521 gcgcacagcg gcacgatggc acggcgtgcc gcgcgtggcg tactggccag caccaacccg
1265581 cgggtgacta gccggtaatc acgagtgatc cggtgccacg cggcctcata cgacgccggt
1265641 gtgtcgtcga cgatggcgct caccgccgcg gcggcctgct tgacggcaag gctgatgcct
1265701 tcgccggtta gggcatcttc gtacccggcc gcgtcaccga ccaaaagcac ccgccccgcg
1265761 acgcgccggg agaccacctg gcgcaaggga ccgcagccac gtgcgtgtcc gcggctcgcg
1265821 tcttgcagat ggtgtgcaag gctgggaaac caggcaagtt cgggtcgttg gcgggacaag
1265881 atcgcgacgc cgaccagatc cggttccacc ggagtcacat aagcctcacc ccaacgggac
1265941 caatgcactt cgacgaagtc cgaccacacc ggcagccggt aatgccagcg caccccgtat
1266001 cgccgtggtg tcccggcggt ggctttgatc ccgacggcgc gccggacggc cgaatgcagt
1266061 ccatcggctg ccaccaacca tttcgcgcga acgccggcgg cggtcacacc atgtgcgtct
1266121 tgctgaatag tggctacccg cgaccggatc cattcagtgt cttgctcttt ggctcgtgcc
1266181 gccagtgccg catgcagcgt ggtgcgtcgc acgccccgcc ccggcccggt gcgaaaccgc
1266241 gcctgcaccc gacgatgttc accaacgtag gcaatcccat gaaagggcag accgaccggg
1266301 tccacgccta gcgaggtcaa ttcggccagg ccaccgggca tcagcccctc gccgcacgcc
1266361 ttgtcgatgg gattctcgcg aggctcggcc acgatcaccg aaagtccacg cgcgcgtgcg
1266421 tgcaatgccg tggcgagtcc gccggggccg ccgccgacga ccaacaggtc ggtgtcgtag
1266481 ctggtcatat gtagcccaga acggagttct ccacccgcag acgaacggtc agcaaggtcg
1266541 cattggccag ggtgaaaacc agtgcggtca accacgccgt gtgcaccagt ggcaacgcga
1266601 acccttcggc caccaccgca acataattcg gatgccgcat ccaccggtag gggccccgcc
1266661 gcaccaacgt ggcgtgcggc aacacgatta cccgggtgtt ccaccgcttg cccagcgatt
1266721 tgacgcacca ccagcgcagg ccctggcttg ccaccactac ggccagcatc ggccagccga
1266781 gccacggtat gaaaggccgg tgcaaggccc acggttcgac gacgcagccc agcagtaggg
1266841 cggtgtgcag gataaccatc accacatagt gtgggcggcc aaactctttg ccgccctgcg
1266901 cgaaagacca ccgcgcgtta cgctgggcca ccaccagctc cgccagccgt tcgaagacga
1266961 ccgccaggat cagcaggtag tacacggccc taccacctaa gaagcaccga ctcggaggaa
1267021 aaacccgggc ctatgcacac tatcctggcg ggaccggcga tgcagcccag cccgaacggt
1267081 ggaatagctc cccctgcgat cgactccata ttgtcagcca cgttactggc gccggatggg
1267141 ttcagattct ggcgagtggg accgccattg ccgggccgtt ccacggcccg tatcgtcgcc
1267201 gcgctgtgct ggattgcgcg gcttctcctc gggccgttcc acggcccgta tcgtcgccgc
1267261 gctaggttgg acgctgtgcg gatcgtggtg agcagtgcca ccagaaatgc gggttcgtac
1267321 acctgtgtca gcaccggcag cgctggatgc cgcgagatta caccgcccct cgctgggccc
1267381 acgcctgggc cggtgaaccc cggcccgccc gctggcaccc tgcgaaccag cctgcacatc
1267441 ctgaccactc caaccgcgaa agtccggcct gcatgagcca atccaccact ccataccgca
1267501 gcagcgtgct tgccgagttt cgtcgtgcga tcaccaatgt cgctgtgccc catcatgaac
1267561 cgccgggaat cgtgcgccgc cgccgtgtgg tcgtcggcgt cacgttggtt atcggcgctg
1267621 tgatgctggg cttttcgctg aggcggacgc ccggcgagtc gagcttttac tggctgacgc
1267681 tcgcgctggc agccgtgtgg atcgccggcg cactgatgtc tggaccgctg catctgggtg
1267741 gcatctgttg gcgcggtcgc aatcagcgtc cggtcatcac cgggaccact gtcgggctgc
1267801 tgctagcagg catcttcggg gtgggtgcaa tgatcgtcag ggcaattcct ggcgcagctg
1267861 aaccgatagc ccgcgtcctg caattcgccc atcagggaac tctgctgccg atcctgctga
1267921 tcaccttgat taacggcatc gccgaggaga tgttctttcg cggtgcgctc tacaccgcgc
1267981 tgggacgacg ctatccggtg accatctcaa ccgtcctgta cgtcggcgcc accatggcca
1268041 gcgcgaatct gatgctcggc ttcgcagcga tcttcgtcgg tacggtgtgt gcgttggagc
1268101 gccgggccag cggtggagtg ctggcaccga tcttgaccca cttcgtgtgg ggcctgatca
1268161 tggtgttcgc gctgcccccg ctgttcgcgg tctgacgcgc gttcaggaac cggtgaagtt
1268221 gggggtgcgg cgttgcagga acgccgctgc gccctcggcg aagtcgtgtg ttcgcagcag
1268281 gacttcctgt ccatccaatt cgcgcgcgaa cgtgggttcc aattcggtga gggcggctgc
1268341 attgatggcg tttttggcct gggcgaacgc cagcgccggg ccggccagca accgtgaaat
1268401 caccttgtcc acctcggcct cgaagtcgct gtccggatat accgcgctga tcaggcccca
1268461 ggccagtgcc tcgcgggccg gcagttgctc ggccagcagc gccagccgca tcgcccggat
1268521 ccggccggtg gccgcggcga ctaacgccga tgcgccgccg tcgggcatca acgctacctt
1268581 ggtgttggcg agcatgaaaa atgcactatc agaagccaat atgaagtcac acgccagcgc
1268641 tagcgagaca gcgacgccga ccgctggtcc ttgaacgaca gctacaaccg ggtgcggtag
1268701 cgcggccacg gcgcgtactg cgcggttggc ctcttcgacg atggcggtcg gcggccctcc
1268761 gccccacaca tcgtccacag acatagacac tccggagctg aaaccgcggc ccaccccgcc
1268821 taggcgcacc accttgacca cgggatcggc cgccgcgcgc tccagcgtgt cggcgatccc
1268881 cgtcaggatt ggcacggtca gcgagttgag actgctaggg cggttgatgc gcaccgacaa
1268941 cactctgtcg gtcagggtga cgttgaggcc tgtgaccggc gttaatgcgg caatcccgga
1269001 atctggcatg tgcagcatcc taaatgaggg ccagctacac agagtggtta atgatgctcc
1269061 gcaaacatgc ccaaccagca gttggagtaa tcggtgagta cacgggcatc gacgcggccc
1269121 agtcgcggga ccgctagcgg gccgagagcg ctcaacggcc ggtgaacatg ggggtccggc
1269181 gctgctggaa tgccgttgcg ccctcggcga agtcgtcagt acgcaggagg agggcctggc
1269241 catccaattc gcgcaggaga gtgggtgcca actcggtgag cgtggccgca ttgatcgcgt
1269301 tcttcgtctt ggcgatagcc agcgctgggc cggccaacag ccgtgagatc aacttgtcca
1269361 cctcggcatc gaagtcggcg gccggataga cggcgctgac caggccccag gacaaggcct
1269421 cggcggccgg cacccggtcc ggcagcagcg ccatatgcat ggcgcggatg cggccgatcg
1269481 cggcctgaac caacgccgac gcgccgccgt cgggcatcaa ccccacgttg gtgtgagcga
1269541 gcatgaaaaa cgcattgtcg gaggccaata cgaggtcaca agcgagcgcc agggagacgc
1269601 cacagccgac ggttggtccc tgcacgacgg caacgaccgg ttgtggtagt gccacaatgg
1269661 cacgcaccgt gcggttggcc tccgcgacgg tgtcggtagg cgggccactg gcccacacat
1269721 cgtcaacgct gattgcccct ccggagctga agccgcgacc ggcgcccccg aggcgcacca
1269781 ccttcacccg tgggtcggtg gccgcgccct cgatcgcgtc ggccatccct gccagcaccg
1269841 gcttggtcag cgagttgaga ctctccgggc gatcgatggt caccgacagc accccgtcgg
1269901 ccagggtgac ggcgagaccc gggacaattg tccgagtgtc gatccggtag ttcgacatgt
1269961 ggttaacact aatcgacgac gccgtcaccg agctgcggcg acatgatctt cgtcgatacg
1270021 ccgtcgaggg cgtcaatggg agacgaaagg ccggtacatt catggcgggt ccgctgagcg
1270081 ggttgcgagt tgtcgagctg gcgggcatcg ggccgggccc gcacgcagcg atgatcctgg
1270141 gggacctcgg tgccgacgtg gtgcgcatcg atcgcccgtc aagtgtcgac ggtatttcga
1270201 gagacgccat gttgcgtaac cggcgtatcg tgaccgccga cctgaagtcc gatcagggac
1270261 tcgagcttgc gctcaaactc atcgccaagg ccgacgtgtt gatcgagggt taccgtcccg
1270321 gcgtcaccga acggctggga ttgggtccgg aagaatgtgc gaaggtcaac gaccggctga
1270381 tctacgcgcg gatgaccggc tggggccaaa ccggcccgcg tagtcagcag gccggtcacg
1270441 acatcaacta catctcgctg aacggcattt tgcacgccat tggccggggc gacgagcgac
1270501 cggtgccgcc gctgaacctg gttggtgact tcggcggcgg ctcgatgttc ctgctggtcg
1270561 gcatcctggc cgcgctatgg gagcggcaga gctccggcaa gggccaggtc gtcgatgcgg
1270621 cgatggtcga cgggtccagc gtgctgattc agatgatgtg ggcgatgcga gcgacgggca
1270681 tgtggaccga cacaagaggg gccaacatgc tcgacggcgg ggcaccctac tacgacacct
1270741 acgaatgcgc cgacggccgc tacgtcgctg tcggcgccat tgagccgcag ttctatgcgg
1270801 ccatgctggc cggattgggt ctagacgccg ccgagctgcc cccgcaaaac gaccgcgccc
1270861 gttggcccga actgcgggcg ctgctgaccg aagcgttcgc gagccacgac cgtgaccatt
1270921 ggggcgcggt gttcgccaat tccgatgcct gtgtgacgcc ggtgctggcg ttcggtgagg
1270981 tgcacaacga gccgcacatc atcgagcgaa acacctttta tgaagccaac ggcggatggc
1271041 aacccatgcc ggctccgcgg ttctcccgca ccgcttcgag ccagccacgc ccgccggccg
1271101 ccacgatcga catcgaggca gtgctcaccg actgggacgg ataggaagga ttcgtatgaa
1271161 gaccaaagac gccgtagccg ttgtcaccgg tggcgcctca ggcctgggtc tggccaccac
1271221 caagcggcta ttggacgctg gggcacaggt ggtcgtcgtg gacctccgcg gcgacgacgt
1271281 ggttggcggg ctcggcgatc gcgcgcgttt tgcgcaagcc gacgtcaccg acgaagccgc
1271341 cgtcagcaac gcgctagagc tggcggattc gctcggcccg gtgcgggtcg tcgtcaactg
1271401 cgccggcacc ggcaacgcga ttcgcgtact gagtcgcgac ggcgtgttcc cgctggccgc
1271461 gttccgcaag atcgtggaca tcaacctagt cggcaccttc aacgtgctgc gactgggcgc
1271521 cgagcggatc gccaagaccg aaccgattgg ggaagagcgc ggcgtcatca ttaacaccgc
1271581 ctcggtggcg gcattcgacg gtcagatcgg ccaggccgcc tactcggcgt ccaagggcgg
1271641 cgtagttggc atgaccctgc cgatcgcccg cgatctggcc agcaagctga tccgggtggt
1271701 caccattgcg ccgggtctgt tcgacacccc gctgctggct tcattgccgg cggaggccaa
1271761 ggcctcactg ggccaacagg tgccgcatcc ctcgcggctg ggcaaccccg acgagtacgg
1271821 ggcgctagtt ctgcacatca tcgaaaaccc gatgcttaac ggcgaggtca tccgtctgga
1271881 cggcgccatc cgcatggcgc cgcgctaagc cgcaccaaaa gaaagacccc cgcgttgcgg
1271941 gggaccggaa tcgggaacaa gaacttaccg acgaaaccat cggctgacgg ctggttcggc
1272001 catgaggagc cgtgcaagca tgcccatggt gtcgctcagc tcgcggtggg cagcgggtgc
1272061 aagtcttcga gctgctcgga ggtgtcgccc tctaccagca tgtcgccgtg gtagagagcc
1272121 tcgaagtcag ccttgatgac gtcggcactc gagtcgtcga tccacatgac agcgagccta
1272181 aaagccgcca ttaaggaatt agtgagtcac gattcggaaa acagtggcaa ttcctaccgg
1272241 tcggtagggt gctgcgccgg catggtggcc ggcatcgcgg gcatgcggca ggtgaaccac
1272301 tcgagcgccc gcatccgtat ctatggcagg cgttgtttga cagttgtaac ttatcgcaga
1272361 taagtcatcg cggatttggt gcgggtccgc gcgaccagca ccggctgcgg aggaaacgca
1272421 acatgctgca gaggatcgct cggctcgcca tcgctgcgcc gcgccgaatc atcgggtttg
1272481 cggtcttcgt cttcatcgcc gcagcggtct tcggtgttcc ggtggctgac agcctgtcgc
1272541 ccgggggttt ccaagatccg cgatcggagt cggcacgggc aatcgaggtg ttgaccgaca
1272601 agttcggcca gagcggtcag aaaatgctga tcgtggttac ggcagccgcg ggcgccgaca
1272661 gcccacctgc ccgcgaggtc gggactgaca tcgtcgaggt gctgcggcgg tcgccgttgg
1272721 tttacaacgt gacctcgccg tggactgtgc caccgactgc cgccgccgac ctgctcagca
1272781 ccgacggaaa atcggggttg atcgtcgtca acgtcaaagg cggcgaaaac gacgcgcaga
1272841 accacgccca aaccctgtca gacgaagtcg cccatgaccg cgacggcgtc accgtccgtg
1272901 ccggcggctc ggcgatggag tacgcccaga tcaatcggca gaacaaagac gacctgctgg
1272961 tgatggagtt gatcgcgatt ccgctgagct tcctggtgct gatctgggtg ttcggtgggc
1273021 tgttggccgc cgggctgccg atggcccagg ccgtactggc cgttgtggga tcgatggccg
1273081 tattgcgact cgttacgttt gccaccgagg tgtcgacctt cgcgctcaac ctgagtacag
1273141 cgttgggcct cgcgttggct atcgactaca cgctgctcat cgtcagtcgc tatcgcgacg
1273201 agctcgccga gggcagtgat cgagacgaag cactgatccg gaccatggcg cttcggggcg
1273261 cacggtgttg ttttcggcgg tcaccgtggc gctgtcgatg tcggcgactg cgctgttccc
1273321 gatgtacttt ctgaagtcgt tcgcctacgc cggcgtggct accgtggcat tcgtcgcgac
1273381 cgcgtcgatc gtgatcaccc cggccgcgat tgtgttgcta ggtcctcggc tagatgcgtt
1273441 ggacgtgcgc cgactggtgc gtcggctgct gggccggccc gatccggtgc acaaaccggt
1273501 caagcaactg ttctggtacc ggtcgagcaa gttcgtgatg cgccgttggc tgccggtcgg
1273561 tacggctgtt gtcgcgctgc tggtgctgct cgggctgccg ttcttgtcgg tgaagtgggg
1273621 tttcccggac gaccgggtgt tgccgcggtc ggcgtcggcc cgtcaagtcg gcgatatctt
1273681 gcgcgatgac tttggccacg atcctgcgac gcagataccc atcgtcgtcc cggacgctcg
1273741 tggtctcggc ccggtcgaac ttgacagcta cgcagccgag ttgtcccggg tgcccgacgt
1273801 atccgcggta gccgccccga cgggcacgtt cgtagacggc agctgggtgg gaacgccgcg
1273861 cggggccacc gggttggctg agggcagcgc gttcctgacg gtgagcagca cggcgccgct
1273921 gttttcgcga gcctccgata tccagctcaa gcggttgcac caggtggcag ggccggccgg
1273981 tcgatccgtc gtgatggccg gtgtcgcgca ggtcaaccgc gacagtgtcg acgcggtgac
1274041 cgatcggctt ccgatggtgc tagggctaat tgccgcgatc acctacgtac tgttgttcct
1274101 gctcaccggc agcgtggtgc tgccggcgaa agcgttggtt tgtaatgtgt tatcgctgac
1274161 cgcggcgttt ggcgcgttgg tgtggatctt ccaggaaggc catttcggtg ccctgggaac
1274221 gactccgagc gggacgttgg tggcgaatat gccggtccta ctgttttgca tcgcattcgg
1274281 tttgtccatg gactacgagg tgtttctggt ctccaggatt cgggagtact ggttggaatc
1274341 cggagccgcg cgacccgcgc gaagaagcgt cgcagaggtg cacgccgcca acgacgagag
1274401 cgtcgcgctc ggcgtggccc gcaccggtcg ggtgatcacc gcggcagcgt tggtgatgtc
1274461 catgtcgttc gccgcgttga tcgctgcgca cgtgtcgttc atgcggatgt tcggcctcgg
1274521 cctgacttta gccgtggctg cagacgccac actggtgcgg atggtcgtgg tcccagcatt
1274581 catgcatgtg acgggccgct ggaattggtg ggcaccgaga cccctggcgt ggctgcatga
1274641 gcggttcggt gtcagcgagg cagcagagcc ggtttcgagg agacgttccc acgccggtgg
1274701 gttgggcaag attgccggac gaagcgacgg tcagacgatc cctgcctcgc tgacgcgcaa
1274761 tggttgacgt ctcgatgaat ggtcttcgcc ggcaacgtgc ccggcggggc cccaacgcca
1274821 cattacggca gctggcggac tgggtgcagg cacgtcgccc atcggagaaa cgacgaggac
1274881 catcggagga atcctggcca tgacgtcagg cgcggccgct tcggcgtcca gggtcgacca
1274941 cccgcttttc gcccggatct ggcccgtggt cgccgcacac gaagccgaag caatacgagc
1275001 cctccgccgg gagaatctgg ccggtttgtc ggggcgggtg ttggaagtcg gggccggcgt
1275061 cgggacgaac tttgcctact acccggtggc cgtcgaacag gtcatcgcca tggagcccga
1275121 gccgcggctt gctgccaagg cccgcatcgc ggccgctgac gcacccgttc cgatagtcgt
1275181 gacggacaag acggtcgagg agttccgcga caccgagacg tttgacgcgg tggtttgctc
1275241 gctggtgctg tgctcggtga gcgacccggg cgcggtgctg gcgcacctgc gttcgctact
1275301 acggcgaggc ggggagctgc gctatctcga gcatgtggcc agcgccggcg ctcggggccg
1275361 ggtgcagcgg ttcgtcgacg cgacattttg gcccaggctg gcgggcaact gtcacacgca
1275421 tcgccatacc gaacgcgcga tcctcgacgc cggattcgtg gtggacagct cccggcggga
1275481 gtgggcattt cccgcctggg tgccgctacc ggtgtcagag ttggctctgg gccgcgcgca
1275541 ccggacctag ctatagctag tactgcagcc gtagataggg attgctgatg ctggcgtgtc
1275601 tgcgctggtc agggcggtga ccgcggcatt gttttcagtt tgtgacaact tctcaatatg
1275661 ccgcggtcgc cgcggctcat agcgtagacc ctgatcggtg gcaggcggag ttctcggcgg
1275721 tgctggatcg gatcgcgccg cgtttcgccc ggcaccagcc gttgcgccat gccggtgaac
1275781 tcatggccgg gatggtttcg ggcttggacc gcaagaattg ctggaccatc gccgagcacc
1275841 gcggtgatac caccccgatg ggttgcagca tctgttggca cgggccagct gggacgccga
1275901 cgatgtccgt gacgatctgc gtgactatcg ccattgatcg atggcgaagg accaggtcac
1275961 cagtatatcg atgatttgaa tagtccagcg ccgacattga tgatatctgt tgacgaatac
1276021 gcttgattta cgatgttcgg ccgcgggcag cgcgctccac cagaccgagc acagcgagga
1276081 cgcgacggcc gtcagcggcg tgctgtgcct caacagcgcc gaccaatagc gaagaaatca
1276141 agtccgtgct cacccgtgac cagggtgtca tgttcgtcga cgggtagaag cttgtcgccg
1276201 cggcgatcgg ctgctctggt gccggctgtg ccgacgggtc ggtccgcatc tgcttcagtg
1276261 attctgtgat gcgaccggca acgtcttcgt tgttgggtgt caatgtggtt cgtcgtcgtc
1276321 ttgttcgcac aggattttcg cggggtggtg gtatcgattt attcgcggtt ggccgtggtc
1276381 gaggtgtggt ggtggtagcc attcggtgtc gccgtgggcg tttttgcggg tcttccagcc
1276441 tttttcgaca aggcgattgt cggggccgca ggccagcgtg aggtcgttga tgtcggtacg
1276501 gtgggtggtt gtccacggcg ttacgtggtg gacctcactg tggtaggccg gggcgtcgca
1276561 acccggcctg gagcagccac gatccttcgc gtacaacatg attcgctgcg ccggggaagc
1276621 taaccgcttg gtgtgataca acgccaacgg cttagcgccg tcaaacaatg ccagatagtg
1276681 gttggcgtgg ctcgccatcc ggataaggtc cgacatcggc acccgcgaac caccaccggt
1276741 tacccccttg ccggtggcgg cttccagctc ctttagcgtg gtgctcacca cgatcgttac
1276801 cggcagcccc ttgtgttggc ccagctcacc ggaggccaac aggccccgca gcgcggccaa
1276861 aaacgcatca tgattgcgtt gcgcctggct gcgggtgtcg cggcgcaccg cgtccgcatc
1276921 cggtgtgtca tccacgagcg gggtctggtc atcggggttg cacgcccccg gtgcggccag
1276981 tttggccaac accgcctcga tggtggcccg caactccggg gtcagcagac cgctgatacg
1277041 tgacatcccg tcaaattcct gcttacccat cgtgatgccg cgcttgcggg cacgctcctg
1277101 gtcggaaaag ttgccgtcgg ggtgcagcca gtccatcagc tgcgtggcca ggccatgcag
1277161 gtgatcggga cgccgactgg tggccagttc ggccagctgg gcctcggcgg cctcgcggat
1277221 acccagatcc accgcggcgg acaactcctt gaagaaggcc tggatctcct taatgtgttc
1277281 tcggccgatc ttgccctcac gttgagcggc cgcggtcgcg gtcaactgcg ctggcagcgg
1277341 ttcaccggtc agggcgcggc gctcaccgag gtcttcggct tcggcgatgc ggcggctggc
1277401 ctcaccggga gtgatgtgta gccggttggc caacgccgtg cgcagcgtcc cgccgagctc
1277461 ttcctcgcag gcttgcccag cgagttggtt gatcaaggcg tgctcggcgg cgccctggcg
1277521 gcgccgttcg acctcgagtc gctgcaaaca ggccagcaat tccggggtgg tcaacgcatc
1277581 gcacttgaga tcgagcaccc gcgacaacga ggcgtggtag gcatccaacg ccgcggagat
1277641 ctcctcgcgc gtgtccgacc tcatgcctcg gattctacga agcaccactg acaagaaccg
1277701 ggccgtcata ggctcggaat gatcagtgag gcagaacgtt tcgctcacag cgaaaacagc
1277761 cgcgccatag cgactgccgc caccaaatgc cgcgtgcacg cagacacgcc agcgtcagca
1277821 atccctatcc acggctgcag tactagggcg tgtctcccaa atttttaggt actggccagc
1277881 gaggattggc cggtgacgcg agtgggtgtg atttcggacg agttctgggc cgtggtcgag
1277941 ccgttgatgc cgtcgcatga gggcaagccc ggcagacggt ttagcgatca ccggcttatc
1278001 ctggaaggga tcgcgtggcg gttccgtacg ggaagtccgt ggcgggacct gcccgctgag
1278061 ttcgggccgt ggcaaacggt gtggaagcgc catcaccgtt ggtcgctgga tggtacctgc
1278121 gacgaggtgt tcgcccacgt tgccgcggtg ttcggggtgg acgctgaggt ggccgaggat
1278181 atcgagaagc tgctgtcggt ggattccacg aacgtgcggg cacaccagca ttcggcgggc
1278241 gcctgctcgg acacgctcgc cacagggggc actgtcggat tacaagaaat ccgccgatga
1278301 acccgacgat catgcgatcg gccgctcgcg cggcgggctg accaccaaga tccatgccct
1278361 gaccgatcag cgcgaagccc cggtgcggat ccggttgacc gcaggccagg ccggcgacaa
1278421 cccgcaactg ctgcccctgc tcgacgacta tcgccatgcc agcaccgaat acgccctggg
1278481 cagcacggat ttccgcttac tcgccgacaa ggcctactca cacccaagta cccgtgccgc
1278541 attacggtct aagaagatca agcacaccat ccccgaacgc caagatcaga tcgaccggcg
1278601 caaggccaag gggtctgccg gcgggcggcc accagcattc gacgccgcgc tctacgggct
1278661 acgcaacacc gtcgaacgcg gcttccatcg actcaagcag tggcgcggca tcgcaacccg
1278721 ctacgacaaa tacgccctga cctacctcgg cggcgtcctg ctggcctgcg ccgtcatcca
1278781 cgcccgagtg ggaactccga aattgggaga cacgccctag ccgagaccgg cgagcgtgca
1278841 tccagggcga gattccgccc ggcaaaccgt cgccctgagt tcacgttcgg cgcccatagg
1278901 cgactatttc agcagggcgg gcaggcgctc caacagcccc ggcaacgctt ggctggccga
1278961 ctcgcggatg ctgatcgtcg cgctgccgga caacggcgtg ggctcgggat tgacttcgat
1279021 cacggcagtg ccgcgcgcca gcgccaggtc gggtaaaccg gccgccgggt agacgatcgc
1279081 cgaggtcccc accacgacca tcacgtcggc gctccctgtc gcctcgaccg cgctccgcca
1279141 cggctcctct ggcagcggct caccgaacca tacgatgtcg ggccggatca gaccgccgca
1279201 gtcgcagacc ggcggctcca cttcgatcgc aggctcgggc atctccggaa gggcgtcggt
1279261 gtagggcaca ccacaacgtg cacaacgaaa ttcgaaaagg ctgccgtgca ggtgatgcac
1279321 cgcaccgctg ccggcgcgct cgtgcagatc gtcgacattc tgggtgatga cgctgacctc
1279381 agcatggtcc tgccaggcgg cgatcgcgcg atgcccgtcg ttgggttcga cgttggccac
1279441 cagataatgg cgccataggt accatcccca gacccgctcg gggttgcgca gccagccttg
1279501 cgtgctggac agctcgtaag ggtcgaatcg ggcccacaat ccgttcttgt catcgcggaa
1279561 cgtcggtaca ccgctttccg cggagatccc cgcgccgctg agcaccgcca ctcgcatccc
1279621 acaaacatag ctgtgcttgg tagatactgg gtacgtggag ctgcgggatt ggttacgggt
1279681 cgacgtgaag gcgggaaagc cgttgttcga ccagctcaga acccaggtga tcgacggagt
1279741 ccgcgccggc gcattgccgc ccggcacccg gctcccgacg gtgcgtgact tggccgggca
1279801 gctgggcgtg gcggccaata ccgtggcccg cgcctaccgc gagttggaat cggcggcgat
1279861 cgtcgaaacg cggggacgct tcggcacttt catttcccgc ttcgatccga ccgacgccgc
1279921 gatggctgcc gcggccaagg aatatgtcgg cgtggcgcga gcgctggggc tgacgaagtc
1279981 cgatgcgatg cgctatctca cccacgtgcc ggacgactga attccagcaa agtcaggcac
1280041 ggccgcagcg gatcgaatac gggcaggcgg taaacggtcg acagcgccat attgacccac
1280101 aggccacggc ccggtggcac ccgcagatcg cggaccgcga cgacaccagg caccttattt
1280161 accaggtccg cggcctgcgc gacggacatg ctgaacggca tgcgcggcac cttgtagcgc
1280221 agcgaggttc gtaacccgag ccggctccac ccagcgaacc agcgcggcgg caggtcgaag
1280281 agcatttggc cgccaggaaa cgtttgagcg cattgggcga ttaaccccag tgcctgttcg
1280341 ggttgtaggt acatcagtaa tccttcggcg gtgatgaaca ccccgccggc gggatcgacg
1280401 gaatccatcc agctgtagtc cagcgcagac tgggcacaca ccgacacgcg cggcgagctc
1280461 ggcagcagcc gtgtccgtaa atcgacgatc ggtggcaggt caactgtcag ccaacggaac
1280521 tggccgcccg ggatggccac gtccaaacgc caaaagctgg tttgcaagcc ctccgccaac
1280581 gccaccacgg tggccgctgg gtgctgatcg agataatgct gtgccgccat gtcgaaggcc
1280641 cgtgctcgta gggcgaagcc ctggccggta gggccgaact tcgcgaagtc gaagtcgatc
1280701 gactcgacca gggctaccgc catcggatcg tcgataatgg catcgcggcg gcgggcctct
1280761 gcggcccggg cgttcagcgt cagcaaggcg gtctcggaga ctccggtgag tgcgacccgc
1280821 tgtttggcgg gcttatgggc actcaccgca acaccttagc cagcgtgcgc aggttgcggg
1280881 tcgtggtcga cgacttgtag cgcttcttgc ccatcgtctg gccgatggtg ctgtccaggg
1280941 tgctgccctt gggtacctgc cagtagagga cgccaagagg gtcgggtcca cgactgatgt
1281001 tctcgtcagg gccggctgtg tcggcgagtg cggatagctc gtcgagtatc gcggcgtcgg
1281061 caacgaaggt gacgtacgac tggtatccct cgagctcgca ttcaaatggg tatgccgtca
1281121 cgatggtgcg caccgtatcg acgtcgtaga tcaacgccca cgcgtcgtag ccgaatcgtt
1281181 cgcgtagcgt ggcttcggtc ttctcgcgca cttccgcggc accgcacgtc gactccagca
1281241 acacgttgcc gctggccagg atggtgcgca cattgcagaa tcccgcatcg gtcaacgccg
1281301 tcgccacctc ggccatcttg aggttgacgc cgccgacgtt gacaccgcgc agaaacgccg
1281361 cgaacttggc catacccgat tgcaccaggc cgccggagaa tgacgcaacg gcgacgtagg
1281421 ctcttggcat ggcccgccaa gtcttcgacg acaagctgtt ggccgtaatc agtggaaact
1281481 ccattggggt gctggccacc attaagcacg acgggcgccc ccagttgtcc aacgtgcaat
1281541 atcacttcga cccgcgcaaa ctgctgatac aggtatcgat cgccgagccg cgagccaaga
1281601 ctcgcaacct gcgtcgcgac ccacgggctt cgatcctggt cgacgccgac gacggatggt
1281661 catacgccgt tgctgagggc actgcgcaac tgacacctcc tgcggcggcg cccgatgacg
1281721 acaccgtgga ggcgctgatt gccttgtatc gcaacatcgc tggcgagcat tcggactggg
1281781 acgactaccg gcaggcgatg gtcaccgatc ggcgtgtgtt gctgacgctg ccgatctcgc
1281841 acgtatacgg cctgccgccc ggtatgcgct aacccccggg gctgcggacc tacggactgg
1281901 gtcggattgc ctcgctgctc ggcgggccgc atcctgcggc ccgcatcgtc gcgaggctgg
1281961 gtcggattgc ctcgctcctc gccgtgccgc atcctgcggc ccgcatcgtc gcgaggctag
1282021 gctgcgggta tgggtgaatc gaagtccccg caagagtcca gctcagaggg tgagaccaag
1282081 cgcaagttcc gggaagccct cgaccgcaag atggcacagt cgtcgagcgg atccgatcat
1282141 aaggatggcg gcggcaagca gtcgcgggcg cacggtccgg tggcgagccg tcgggaattc
1282201 cgccgcaaga gcggctagcc acggggcgcg gctgctcagc ggcgacccga acgttgccga
1282261 agatgctcat caagaggtcc gtcccgacag ctctacactg aggacgtgcc aaatctgcag
1282321 cttgtccaag agccggcagc cgacgcgctg ctgaacgcca acccattcgc gttgctggtg
1282381 ggcatgttgc tcgaccagca ggtgccgatg gagaccgcct tcgccgggcc gaagaagatc
1282441 gccgatcgga tgggtagctt tgacgccggc gacatcgccg actacgaccc ggataagttc
1282501 gtcgcactgt gctcggaaag gcctgctata caccgatttc cgggctcgat ggccaaacgc
1282561 atccaggcgc tcgcgcagat catcgtggac cgctacgacg gggatgcggc cgcattgtgg
1282621 accgccggcg aacctgacgg gaacgagttg ctgcggcggc ttaaggggtt acccggcttc
1282681 ggtgagcaga aggcgcggat ctttctcgcg ttgcttggca agcagtacgg agtgacgccg
1282741 aagggttggc aggtggcagc cggggagttc ggtcagcccg gcacctatct atccgtcgcc
1282801 gatatcgtcg acgccgggtc gcttgggcag gtgcgatcgc acaagaggca aaggaaagcg
1282861 gcggccaagg cagagggaaa ggcgccaacg tgaagacaca cctgacgtgt ccgtgcggcg
1282921 aagccatcac cggcaaggac gaggacgagc tggtcgagct gactcaggcc caccttgcca
1282981 gcgttcatcc cggcctggag tacgaccgcg acgccatatt gttcatggcg tactgatgga
1283041 ccattcccgc tggtgctagg gcaccaccgt tgagccgatc gtcggcatga actggcactg
1283101 ccggtccttg gtggtcacct gcccgaagat cgttgacatg atgctgcctg aaccggtgtc
1283161 ggcgattacg gtcaacgtgg tcggtccgtc cggattgatg tccgaacgcg gccgcagggt
1283221 ggcgctgccg gactttcccg tggtcaggtt cacccacgtg acgttcagcg gcaacctctg
1283281 cacgtcggcg ggccccggcg tgccgacggc cgtgaacacg taggcggtct ggccgggtcc
1283341 gggaccgggc agcgggatct tggcgggccc cgccaccgac agcgcggtcg cgatggaatt
1283401 gctgccgtcc gccacacaat tggggccgat cgaggggtac atgaagtcct gtgtgggcgg
1283461 agcgtcggcg ccgaagcccg aggcaggcgc cggagcggcc gctggcgccg gtgccgccga
1283521 ggccggcgcc ggagcggcgg cgcgcggcgc aggtggcgcc ggtggcggcc ccggtaccgc
1283581 aaccggttgg gctgcgtcag gtgctggtgc cggcgcggaa gccggcggcg cggcgaccgg
1283641 cggcgtaacc gtaggtgcca cagcgggtgc ggggcccgcg gcgtgggatg gatcgatgcc
1283701 ggtcggaaga tgtgcctgca cacctggctc ggcgcccagt gggggcacat gcggcaccgg
1283761 gatggcctcg ggcagggcga caccatgagg cgccggcaca cccagggcag cagagtcggg
1283821 attggtcggc tcagccacaa actggttcac cgaggaagcg acgttcttgg attcggtggg
1283881 cactgccgga ttgccggcga acgcagacgc tgcggccatg agcagttgcg tcgcctgtgc
1283941 cgggttcatc gccgcttgct ggattatcgg actcagctgg gccaacgccg gcaagcccgg
1284001 tagctgttga gtggggttgg gctgcggcgt cgccgggtcg gctgccgcgt tcggacacag
1284061 cgcgaacgcg gcagccgagg tgatgacgac ggcggccaaa cctttgcaca cactccaagt
1284121 gcttgccacg gtggtgttct cccggtgttc ggtgttggtc agccttctca cagatgcgtc
1284181 agggcagcgc ggcgagcaac gacggcggcc cgggcggtaa cgcgggcgcg ccgggagccg
1284241 gcggcgtcgg cgcgatgggc gctgccggaa tgacccccga tgcgagcgcc ggtaggtcgg
1284301 ctggcagcga aagctgttgc ggcacttgga gcggaaggta gggcagctgc ggtaggtcga
1284361 ccttcgccga cggcacgccg ggaacggagg ccggcaccgc ggccgccgcc ggggccggtg
1284421 cggttatccc cgggatcggg gcgttcactc cgggaatggt cggagctgcc gccggggcgg
1284481 tgacggggag cgccggtgcc gccggggtta tccccgggat cggggcgttc actccgggaa
1284541 tggacggagt tagcgcgggg gccgcggctg ccgccggtgc ggccggcgtc agtcctggaa
1284601 aggtggcggt tatcccgggg gcggcgggtg cgggttccgc aactttgggg gcgctcagcg
1284661 gcggagtggc gcccagagcc gtcgcgaggt tttgcaggat ttgcggtgcg ttggcggccg
1284721 agctgatcag ctgctgcgga atgttgggag caggcgccgg cgccggtgcc ggatctgcgt
1284781 gagcgatacc gcccgtaagt agtgcggcgg acgaaccgac caagacggcg gcggcgcgga
1284841 caaacgtcca gatggttggc atgtctctcc ctggttagcg gtgacgggtc tcgccgaacg
1284901 tatcgcggtg cagatgtgac tcaagtgaca cgtgtggcat ttatgtgatt gttacggata
1284961 cgagtggttg tggtgaccgg gcacccgagt gatgtgccgc accctgatcg acggcccggt
1285021 gcgctcggcg atcgctaaag tcaggcagat agacaccacc tcatccaccc cggcggccgc
1285081 caggcgcgtg acctcaccac cggcccggga gacacgcgcc gccgtgctgc tactggtcct
1285141 cagcgtcggt gcgcgactcg cctggaccta tctggcgccc aacggcgcaa acttcgtcga
1285201 cctgcacgtt tacgtgagcg gtgcagcgtc cctcgaccat cccggcaccc tgtatggcta
1285261 cgtctacgct gatcagaccc cggacttccc gctgccgttc acctatccgc cgtttgcggc
1285321 tgtggtcttc tacccgttgc atttggtgcc gttcggtctg atcgcgctgc tgtggcaagt
1285381 agtgacgatg gccgcgctct acggcgcggt tcggatcagc cagcgcctga tggggggcac
1285441 cgctgagacc ggtcatttcg ccgcgatgtt atggacggcg atcgccatct ggatcgagcc
1285501 gttgcgcagc acctttgact atgggcagat caacgtgctg ctgatgctgg cggcgctttg
1285561 ggcggtctac accccgcggt ggtggctatc gggactgctg gtcggggtgg cctcgggtgt
1285621 caagttgacg ccggcgatta ccgctgtcta cctcgtcggc gttcggcggt tgcatgcggc
1285681 cgcattttcg gtggtcgtgt tccttgccac cgtcggcgtg tcgctactgg tcgtcggcga
1285741 tgaagcccgc tactacttca ccgacctgtt gggcgacgca ggccgggttg ggcccatcgc
1285801 cacctccttc aatcaatcct ggcgcggcgc gatttcccgg attctcggtc acgacgccgg
1285861 ttttggtccg ctggttctgg ctgcgatcgc cagtacggcg gtattggcca tcctggcctg
1285921 gcgtgcgctc gacaggtccg atcggctggg caaactattg gtggtcgagt tgttcggcct
1285981 gctgctctcg ccgatctcct ggactcacca ctgggtgtgg ctagtgccgc tgatgatctg
1286041 gctgattgac gggccagcgc gtgagcgccc gggcgcccgg attttgggct ggggctggtt
1286101 ggtgttgacc atcgtcggcg tgccgtggtt gctgagcttt gctcaaccga gcatctggca
1286161 aatcggccgg ccgtggtatt tggcctgggc cggtctggtc tacgtggtgg cgacgctggc
1286221 gaccttgggc tggatcgccg cctccgagcg ttacgtgcgc attcggccgc ggcgcatggc
1286281 caattaggcc ccaaacattg cgtcgatatc gtgcgccatc gcaatgtcgt tttccgtgat
1286341 accacctacc gcatgcgtaa ccagcgcgaa agttactgtt cgccaacgga tatcgatgtc
1286401 cggatgatga tttacctcct cggctcgctc ggccacccgg cgtacggcgt cgataccggc
1286461 cataaacgtc ggaaacttga ttgacctacg caggacacca ccggcgcgct gccagccgtt
1286521 gaggtcgtgc agtgcggcgt cgacctgctc atccgttaac acagccatac ctcgacggta
1286581 taccgtcaca ggtcatgctg aatcagatcg tggttgccgg agccatcgtc cgcggttgca
1286641 cggtcttggt ggcgcaacgc gttcggccac cggagttggc gggtcgttgg gaacttcccg
1286701 gcggtaaggt cgccgccggc gaaaccgagc gcgccgcgct ggcccgagag ctcgccgaag
1286761 aactgggact cgaggtcgcc gacctcgcgg tgggcgaccg tgtgggcgac gatattgcgt
1286821 tgaacggcac gacgacgctg cgggcctatc gcgtgcatct gcttggcggc gaaccgcgtg
1286881 cgcgtgacca ccgggcgctg tgctgggtga cggcggccga actgcacgat gtcgactggg
1286941 taccagccga ccgcggctgg attgcggacc tggcgcgaac cctcaacggg tccgccgcag
1287001 atgtccaccg tcgctgttag gaaaccgacg gtgtggttga cggtggccgc cgtcaacttg
1287061 gttagaacaa cgtgacaaaa cgttaacttg ggtttgcatg cccgtagcga ttacgatggt
1287121 tttctggacg cgtggcgaca acttccgggc aggacgctga cgcccatcca tcgagatacc
1287181 cgatgttgac gagaggggtc cccgacccgg cggaccgggg cttgacgggc gcaatgcggc
1287241 gcggccggcc agcccgtaac gtccagcgag tgcggtcgcg cgccgacggc ccggccccac
1287301 accgctcatg acgaggaggg tcatcccgtg accgttacac ctcacgtcgg tggaccgctc
1287361 gaagagctgc tggagcgcag cgggcgcttc ttcaccccag gtgagttctc ggccgacctg
1287421 cgcaccgtaa cccggcgcgg cggccgcgaa ggtgacgtgt tctaccgcga tcggtggagt
1287481 cacgacaaag tggtccgatc cacgcacgga gtcaactgca ccggatcctg ctcatggaag
1287541 atctacgtca aagacgggat catcacctgg gaaacccagc agaccgacta cccgtcggtg
1287601 ggcccggacc ggcccgaata cgagccacga ggttgtcccc gtggcgcgtc gttctcctgg
1287661 tacagctatt cgccgacgcg ggtgcgctat ccgtatgccc ggggcgtgct ggttgagatg
1287721 taccgggaag ccaagacccg cctgggcgac ccggtgctgg cgtgggccga cattcaggcg
1287781 gatcccgagc gcagacgccg ctatcaacag gcccgcggca agggtgggct ggtccgggtg
1287841 agctgggccg aggccagcga gatggtggcc gccgcccacg tgcacaccat caagacatac
1287901 ggcccggacc gggtcgccgg cttctcgccg attccggcga tgtcaatggt cagccatgcc
1287961 gcggggtccc ggttcgtgga gctgatcggc ggcgtgatga cgtcgttcta cgactggtac
1288021 gccgacttgc cggtggcctc gccgcaggtg ttcggcgacc agaccgacgt gcccgaatcc
1288081 ggcgactggt gggatgcgtc gtatttggtc atgtggggct ccaacgtccc gatcacccgg
1288141 acgcccgacg cacattggat ggcggaggcc cgttaccgcg gcgctaaagt cgttgtcgtc
1288201 agcccggact acgccgacaa caccaagttc gccgacgagt gggtgcggtg cgccgccggt
1288261 accgataccg cgctggcgat ggcgatgggc cacgtgatcc tgtcggaatg ttacgtccgt
1288321 aaccaggttc cgttctttgt cgactatgtg cgccgctaca ccgacctgcc gtttttgatc
1288381 aagttggaaa agcggggcga cctgctggtt cccggaaagt tcttgaccgc ggccgacatt
1288441 ggtgaagaaa gtgagaacgc ggcgttcaaa cccgccctgc tggatgagct tacgaatacc
1288501 gttgtcgtgc cgcagggctc actgggattc cgtttcggtg aggacggtgt tgggaagtgg
1288561 aacctggacc tgggttcggt ggtgccggcg ctaagtgtgg agatggacaa ggctgtcaac
1288621 ggcgatcgca gtgctgaact ggttacgctg cccagctttg acaccatcga cgggcacggt
1288681 gagacggtgt cgcgtggggt gccggtgcgc cgggcgggca agcatctggt gtgcacggtg
1288741 ttcgatctga tgttggccca ctacggggtg gcgcgtgcgg ggctgcccgg cgaatggccg
1288801 accggctacc acgaccgaac ccagcagaac accccggcct ggcaggagtc gatcaccggt
1288861 gtgccggccg cgcaggcaat ccggtttgcc aaggaattcg cccgcaacgc gaccgaatcc
1288921 ggaggacggt cgatgatcat catgggcggc ggaatctgtc actggttcca cagcgatgtc
1288981 atgtaccgct cggtgttggc gctgctcatg ttgaccggat cgatgggacg caacggcggc
1289041 gggtgggcgc actacgtcgg ccaggagaag gtgcgtccgt tgaccgggtg gcagacgatg
1289101 gcgatggcca ccgactggtc gcggccgccg cgtcaggtgc ccggcgcgtc gtactggtat
1289161 gcgcacaccg accaatggcg ctacgacggc tacggcgcgg acaagcttgc cagcccggtg
1289221 ggtcgcggca ggttcgccgg caagcacacc atggacctgc tgacctcggc cacggcgatg
1289281 ggctggagcc cgttctatcc acaattcgat cggtccagtc tcgatgtcgc cgacgaggcc
1289341 cgcgccgcgg gccgcgacgt gggtgattac gtcgccgaac aacttgccca gcacaagctg
1289401 aagctctcga ttaccgatcc ggataacccg gtcaactggc cgcgggtgct caccgtctgg
1289461 cgggcgaacc tgatcggctc gtcgggcaag ggcggcgagt atttcttgcg gcatctgctg
1289521 ggcaccgact ccaacgtaca gtccgaccct cccaccgacg gtgtgcatcc ccgggatgtg
1289581 gtgtgggaca gcgacattcc agagggcaag ctcgacctga taatgtcgat cgacttccgg
1289641 atgacgtcga cgacgctggt gtcggatgtc gtgttgcccg ccgcgacctg gtacgagaaa
1289701 tccgacctgt ccagtaccga tatgcacccg tacgtgcact cgttcagtcc ggcgatcgat
1289761 ccgccgtggg aaacccgttc ggactttgac gcattcgccg ccatcgcgcg tgctttcagt
1289821 gcgctggcga aacgtcatct gggcactcgc accgatgtgg tgctgaccgc gctgcagcac
1289881 gacaccccgg atgagatggc atatcccgat ggcaccgaac gtgattggct ggcgaccgga
1289941 gaagtcccgg tgccaggcag gacgatgagc aagctcactg tggtggagcg ggactacacc
1290001 gcgatctacg acaagtggct gaccctggga ccgctcatcg accagttcgg gatgaccacc
1290061 aagggatata ccgtccatcc cttccgggag gtcagcgagc tggcagccaa cttcggggtg
1290121 atgaattccg gtgtggcggt gggtcgtccg gcgatcacca cggctaagcg gatggctgac
1290181 gtgatcctgg cgctgtccgg cacatgcaac gggcgactcg cggtcgaggg attcctcgag
1290241 ctggagaagc gtaccgggca gcggctggct catctggccg agggcagcga ggaacgccgc
1290301 atcacctacg ccgataccca ggcgcgtccc gtgccggtga tcaccagccc ggaatggtcg
1290361 ggcagcgaga gcggtggccg ccgctacgcg ccgttcacga tcaacatcga gcatcttaag
1290421 ccgtttcaca cgctcaccgg gcgtatgcac ttctacctgg cgcatgactg ggtcgaagaa
1290481 ctcggcgagc agttgcccgt ctatcggccg ccgctggaca tggcgcggct gttcaaccag
1290541 cccgagctcg gaccgaccga cgatggactc gggctcaccg tgcgctatct gacgccgcac
1290601 tccaagtggt cgtttcactc gacctaccag gacaacctat acatgttgtc gttgtcccgt
1290661 ggcggtccga cgatgtggat gagcccgggt gacgcggcga aaatcaatgt gcgcgacaat
1290721 gattgggtag aggcggtcaa tgccaacggc atctacgtgt gccgggcaat cgtcagccac
1290781 cggatgcccg agggtgtggt gttcgtctac cacgtgcagg agcgcaccgt ggacacgccg
1290841 cgcaccgaga ccaacggcaa acgcggcggc aaccataacg cgctgacccg cgtacgaatc
1290901 aaacccagcc acctggccgg tggctacggc cagcacgcgt tcgcgttcaa ctacctgggt
1290961 ccgaccggta accagcgtga cgaggtgacc gtggtgcgcc gccgcagcca ggaagtgcgg
1291021 tactgaccaa tgaagggccc gagcgacgct tgcggagcga gacgatgaag gtcatggcgc
1291081 agatggcgat ggtgatgaac ctcgacaaat gcattggttg ccatacctgc tcggtgacct
1291141 gcaagcaggc ctggaccaat cgctcgggaa ccgagtacgt gtggttcaac aatgtcgaaa
1291201 cccgtccggg tgtgggctac ccgcgcacct acgaggatca ggagcggtgg cgcggggggt
1291261 gggtgcgcga caagaagggc cggctgcggc tgcgcgacgg cggccggatc cataagctgt
1291321 tgcgcatctt tgccaacccc aagctgccca ctatcggcga ctactacgag ccgtggacct
1291381 atgactacga aaacctgaca tcggcgccgg cgggtgacac ctttccgacc gcggcgccgc
1291441 gaagcctgat cagcggcaat ccgatgaagg tgtcgtgggg atccaactgg gacgacaacc
1291501 tggccgggtc gccagagatc gtgccgaacg acccggtgct aaagaaggtc aaccaagtca
1291561 accaagaggt caagctgaag cttgaagaga ccttcatgtt ttacctgccg cggatctgcg
1291621 agcactgcct gaacccgtcg tgtgtggcgt cgtgtccgtc gggggcgatg tacaagcgca
1291681 ccgaggacgg catcgtgctc gtcgaccagg accgctgccg cggctggcgg atgtgtgtgt
1291741 ccgggtgccc atacaagaag gtgtatttca accacaagac cggcaaggcc gaaaagtgca
1291801 ccctgtgcta tccgcgcatc gaggtggggt tgccgacggt gtgctcggaa acgtgtgtgg
1291861 ggcggctgcg ctatctgggt ctggtgctct atgacgtcga tcaggtgctg caggccgcgt
1291921 cggtggaaag cgacaccgac ctctacgagg cgcagcgccg gatcctgctg gacccgcacg
1291981 atccgcgggt gatcgccggg gcgcgcgcgg aaggcatcgc cgacgagtgg atcgaggccg
1292041 cccagcggtc cccggtgtac gcgttgatca acacctaccg ggtggcgctg ccgctacatc
1292101 cagagtaccg gaccatgccg atggtctggt acatcccgcc gctgtcgccg gtggtcgacg
1292161 cggtcagccg cgacgggcac gacggggagg acctgggcaa tttgttcggc gcgctggacg
1292221 cactgcggat tccgattgcc tatctggccg agctgttcac cgcgggcgac accgaggtgg
1292281 tcgcgggcgt gttgcggcgg ctggcggcga tgcgctgcta catgcgcgac atcaacctgg
1292341 gccgggagac ccagccccac atcccggaat cggtcgggat gaccgaggag cagatctacc
1292401 agatgtaccg actgttggct gtggcgaaat atgaagagcg ctatgtcatt ccgacgtcgt
1292461 acgcggggga gctgccggcc gcggcgatga ccgacgatat ggggtgctcg ttgtcggtcg
1292521 acggcggacc gggaatgtac gagtccggtc cgttcgggca gggcagccct actccggtgc
1292581 caatcgccgt ggagagcttc cacgctctgc agcatgccgg tagcgcggcc accggcggcg
1292641 ctggccgatc ccgggtcaac ctgctcaact gggaccccaa cggcgcagcg gcggggctct
1292701 tcccggagcc tcagcccagc aaggatgtgg tccagcgatg aagttgctgt ctcgtgtccg
1292761 agagcggtcg agcgccacca caatgaggga ccgactggtg tggcagtcgg cctcgctact
1292821 gctggcctat ccggatgacg ggctggccga gcggctgcac atggtcgatg cgctgcgcgc
1292881 ccaccaaacg ggcccggcgg cggcgctgct agggcgaacg gtagcggagt tgcgtgccct
1292941 ggcgccgatg gccgcggcgg cgcagtacgt cgagaccttc gatatgcgac gccgatccac
1293001 gatgtatctg acgtactgga ccgccgggga cacccgcaac cgcggccggg agatgctggc
1293061 gttcgccacc gcctatcgag acgccggcgt caagccgccg cgtaccgagg cgcccgacta
1293121 cctgcccgtc gtgctcgagt tcgccgccac cgtcgacccc gaggccggac gtcggctgct
1293181 gaccgagcac cgtgtgccga tcgacgtgtt gcgcggcgcg ctggccgacg ccaagtcacc
1293241 ctatgagtac accgtggcgg cgatctgcga gacactgccc gctgccacca accaggaagt
1293301 gcgtcgggca caacgcctag ctcagtcggg gccgcccgcg gaagccgttg gtttgcaacc
1293361 gtttaccttg accgtcccgc ccaagcgcgc cgagggggcc tgaccttggc cgtcttggac
1293421 ttggttgaga tcttctggga tgccgcgcct tacgtcgttg tggcgatcgc ggtggtcggc
1293481 acctggtggc ggtatcgcta cgacaagttc ggctggacca cacgctcgtc gcagctctac
1293541 gagtcgcggt tgctgtcgat cggcagcccg atgttccatt tcggcagctt gctggtgatc
1293601 atgggccacg tgatgggcct gttcattccg gattcctgga ccagagcgtt cggcatgagc
1293661 gatcacctgt accatctgca ggcgctgctg cttggcgcgc ccgccggttt cgccactctg
1293721 ctcggtatcg ggttgctgat ctatcggcgg cgcatccaga caccggtgtg gctggctacc
1293781 actcggaatg acaagctgat gtacctggtg ctggtgtgcg cgatcgtggc tggcctggca
1293841 tgcacgctga tgggcgccac ccatgagggc gatatgcacg attaccggcg ctcggtgtcg
1293901 gtctggttcc gctcgatctg gatgctagcg ccgcgtggcg atctgatggc ccaggcgacg
1293961 ctgtactacc aggtgcatgt gctgatcgcg ctcgcgctgt ttgcgctctg gccgtttacc
1294021 cgattggtgc acgcgttcag cgcgccgatc gcctacctgt tccggcccta catcgtgtac
1294081 cgcagccgcg aggtggcggc caagcacgaa ttgatcggtt ccgcgccgcg tcgtcgtggg
1294141 tggtagttct ctgccacaat caccgtcgtg ccattccgca acgttgccat cgtcgcgcac
1294201 gtcgaccacg gcaagaccac cctggttgac gccatgttgc ggcagtccgg ggcgctgcgt
1294261 gaacgcggtg agctgcagga acgggtgatg gacacgggcg atctggagcg ggagaagggc
1294321 atcaccatcc tggccaagaa caccgccgtg caccgccatc acccggatgg aaccgtcacc
1294381 gtaatcaatg tcatagacac cccggggcac gcggacttcg gtggcgaggt ggagcgcggg
1294441 ctgtccatgg tggacggggt gctgctgctg gtcgacgcct ccgagggtcc attgccgcag
1294501 acgcggtttg ttctgcgtaa agcgctggcc gcccatttgc cggtgattct ggtggtcaac
1294561 aagacagacc ggcccgacgc ccgcatcgcc gaggtcgtgg acgccagcca cgacctgttg
1294621 ctagatgtcg cgtccgacct tgacgacgaa gcggccgcag cggccgaaca cgcgctgggc
1294681 ctgccgacgc tgtacgcatc cgggcgcgcc ggggtggcga gcaccacggc gccgcccgac
1294741 ggccaggttc ccgacggcac caacctggat ccgttgttcg aggtgctcga aaagcatgtg
1294801 ccgccgccga aaggagagcc ggacgcaccg ctgcaggcgc tggtcaccaa cctggacgcg
1294861 tcgacctttc tgggtcggtt ggcgctgatc cgcatctaca acggccgcat ccgcaaaggc
1294921 cagcaggttg cgtggatccg tcaggtggat ggtcagcaga ccgtcaccac tgccaagatc
1294981 accgaattgt tggccaccga aggcgtggaa cgcaaaccaa ccgacgctgc cgtcgccggc
1295041 gatatcgtcg ccgtcgccgg cctgcccgag atcatgatcg gcgacacgct ggccgcttcc
1295101 gcgaatcccg ttgccctgcc caggattacc gtggacgagc cggcgatctc ggtcaccatc
1295161 ggcaccaaca cctcgccgct ggcgggcaag gtgggtggtc acaagctcac cgcgcgcatg
1295221 gtccgaagca ggctggatgc cgagctggtg ggcaacgtgt cgattcgtgt cgtcgacatc
1295281 ggcgccccgg acgcctggga ggtacagggt cgcggcgagc tggcgctggc ggtgctggtc
1295341 gagcagatgc gccgagaggg tttcgaattg accgtgggta agccacaggt ggtgaccaag
1295401 accatcgatg gcacgctgca cgagccattc gagtcgatga ccgtcgactg ccccgaggag
1295461 tacatcggcg cggtcacgca attgatggcc gcgcgcaagg gccgcatggt ggagatggcc
1295521 aaccacacca ccggctgggt ccgcatggac ttcgtggttc ccagtcgcgg cctgattggg
1295581 tggcgcaccg acttcctcac cgagacccgt ggctccggtg tcgggcatgc ggtgttcgac
1295641 ggataccggc catgggcggg ggagatccgg gcccgccaca ccggttctct ggtatcggac
1295701 cgggccggcg ccatcacacc gttcgcgttg ctgcaactcg ccgatcgggg gcagttcttc
1295761 gtcgagcccg gccaacagac ctacgagggc atggtcgtcg ggatcaaccc ccgtccggag
1295821 gacctcgaca tcaatgtcac ccgggagaag aagctgacca acatgcgctc atcgaccgcg
1295881 gatgtcatcg agacgctggc caagccgctg cagctggatc tcgagcgcgc catggagtta
1295941 tgtgcgcccg acgaatgcgt cgaggtgacc ccggagatcg tgcggatccg caaagtcgag
1296001 ctggccgccg ccgcccgggc tcgcagccgg gcgcgcacca aggcgcgtgg ctagcaactt
1296061 ggcgcgctgg ccgcgcgagc gtaacgccac tgcgaaatcc agcccggctt ttcgcagccg
1296121 ggttacgctc gtgggggtac tggatagcct gatgggcgtg cccagcccag tccgccgcgt
1296181 ctgtgtgacg gtcggcgcgt tggtcgcgct ggcgtgtatg gtgttggccg ggtgcacggt
1296241 cagcccgccg ccggcacccc agagcactga tacgccgcgc agcacaccgc ccccgccgcg
1296301 ccgccctacc cagatcatca tgggcatcga ctggatcggc cccgggttca acccgcattt
1296361 gctgtccgac ctgtcgccgg tgaacgccgc aatcagtgcg ttggtgttgc ccagcgcgtt
1296421 ccggccgatt ccggatccca acacgccgac cggttcgcgc tgggagatgg acccgaccct
1296481 gttggtttcc gccgacgtga ccaacaacca cccgttcacg gtgacctaca agatccggcc
1296541 cgaggcgcag tggacggaca acgccccgat cgccgccgac gacttctggt atctgtggca
1296601 gcagatggtc acacagccgg gcgtcgtcga ccccgccgga taccacctga tcaccagtgt
1296661 ccagtcgctc gagggcggta agcaggccgt cgttacgttc gcacagccct accccgcttg
1296721 gcgtgagttg ttcaccgaca tcctgccggc gcacatcgtc aaggacatac cagggggctt
1296781 cgcgtccggt ttggctcgag cgctgccggt gacaggtgga cagtttcggg tggaaaacat
1296841 cgacccacag cgcgatgaga tcctgatcgc ccgcaatgac cgttactggg gcccaccttc
1296901 caaacccggc atcattctct tccgccgggc cggggcgccg gccgcgctgg ccgattcggt
1296961 acgtaacgga gacacccagg tcgcccaggt gcatggtggc tcggcggcct tcgcccagtt
1297021 gtcggccatc cccgacgtgc ggaccgcccg gatcgtgaca ccgcgggtca tgcagttcac
1297081 gctgcgggca aacgttccca agctggccga cacccaggtt cgcaaggcga ttttggggtt
1297141 gctggacgtg gacctacttg ccgccgtggg cgccggcacc gacaacaccg tcaccttgga
1297201 ccaggcgcag attcgttcgc cgagtgaccc gggttatgtt ccgaccgcgc ctcccgcaat
1297261 gagcagcgcc gccgcgctgg gtctgctgga ggcatcggga ttccaggtcg acaccaacac
1297321 gtcggtgtcg ccggcgccgt cggtccccga ttcgacgacc acgtcggtga gcaccgggcc
1297381 gccggaagtc atccgcggcc ggatcagcaa ggacggcgaa cagttaacgc tggtcatcgg
1297441 ggtggccgcg aacgatccga cctcggtggc ggtcgccaac actgctgccg accagctgcg
1297501 cgacgtcggc atcgccgcga ctgtgctggc gttagacccg gtcacgctct atcacgacgc
1297561 gctgaacgac aatcgggtag acgccattgt gggctggcgc caagccggcg gaaacctggc
1297621 gacgctgctg gcctctcgtt acggctgtcc cgcattgcag gcgacgacgg tcccggctgc
1297681 gaatgcgccg acgacggccc cgtccgctcc cattggccct acgccgtccg ccgcgcccga
1297741 caccgcgaca ccgccaccaa cggcgccgcg ccgcccatcc gacccgggcg cgctggtaaa
1297801 agcgccgtcg aatctcaccg gcatctgcga ccgcagcatc cagtcgaaca tcgatgccgc
1297861 actcaatggc accaagaaca tcaacgacgt gatcaccgcg gtcgaaccgc gactgtggaa
1297921 tatgtcgacc gtgttgccga tcctgcagga caccacgatc gtcgcggccg gcccgagcgt
1297981 gcagaacgtc agcctgtctg gtgcggtgcc agtgggcatc gtcggcgacg ccggccaatg
1298041 ggtgaagacc gggcaatagc cctggtcacg ccggcggaat cgtcggctag ctctcgcggc
1298101 gttcgccggt ggtgaggatc atggcgtcga taatgcgtgt gagctgctca cggtccggcg
1298161 gggatccggt aaacaagaca tgctgatgga tcaaggccgg tccgattcgt gcggtcatcg
1298221 gagtcagagt tgccgggtcg atttcgccgg aacgcacgcc cgcctgcagg atggactcga
1298281 caattcgcag ccgcggggcc cacaccgagt tgatgaagat ggcgcgcagc tcgggctcgt
1298341 gtaggagctg gctgacgatt tccatgctgg ggagggccgt cttgccggcc aggatttcgc
1298401 agttggcggt gaacaccgcc agcagattct cccttgccga ccggtcagcg cgcggctcgg
1298461 gtaccggcgg caaagcgtat tgcaccgcgg ccagcaccag ctcacgtttg ccggcccacc
1298521 gccgatacaa cgcggctttg ccggtttggg cgcgtgccgc gatgccttcc atggtcagcc
1298581 cgccgtatcc ggcggattcg agttcggcca gcgtcgcatc gtagagcgca cgctcaagca
1298641 cctcgccgcg ccgccggtac gggttggcct ttgcgggtgc gctcaccgtc atgctgcgat
1298701 actagccaac tgcggctttt ccgccggcgc ggttcgatcg atgcatcagg tgaggccctt
1298761 ttgctagccg gcggcgggtg accgcagtat cactccggaa cgggttcttg ccgcgacggc
1298821 gcccacagcg cccccggcca ggcttgccaa tcccagctgg gcccacgagg ttcccgacgg
1298881 accgcccggc gcggaggtcg ggacggcttt ggccaacggc gtaatcgatt tgtccgcaac
1298941 ccagctgggg ggcaccgaca accccccgat cgtatccgca tttcccaatg ttgccgacac
1299001 cgcgggcctg accgcgttgg gtagcaactc cagcgggccc ttgagcgtgg gtgtcaggct
1299061 ccgcatggcg aggttgccca tcatctggcc catgttgctg ccctcgacaa aggccaacac
1299121 gtattccacg ggtatcgacg agattcgcgc ggctgtgagc gggtaggtgc ccttcgtcaa
1299181 cagcgtccac agcttcgaag gcagattctt ggtcgccggc gcggcgaatg accccaccgt
1299241 ctcggacacc gaaccgatca gttcataaag tctggccagc gcgcccgggt tggcgatcgg
1299301 cgccgggggc gagaacggtg tcagccgtgc ggcggccgcc gccattgtgg cgtagaggtt
1299361 catcgcctcg ccatcttggg accagtactg ggcatacagt gcatcgaggg caaagatcgc
1299421 gggggtgtga atcccgaaaa tgttggtcgt ggcgagagcg aggcgcgtca gtcggttggt
1299481 ctcgatcacc ggcagcggca cgtgtgctgc gtgcgccgct tcataggcgc ctgccacgac
1299541 gctgatgtgg tcggcgacga gttcagccag ggaagcggtc gtgacaatcc aggcccgaaa
1299601 tggggcgacc gcagctgcca tgatcgtcga cgatggcccc cgccacgatg tgatcagccc
1299661 gttgatctca ctctcgaacc gactggccgc gtagctcagc tcgttggaca gattcttcca
1299721 ggcgttcgcg gctactagaa acggacgagc gctaccttgg atgttgaggg agttgaactc
1299781 cggcggaaaa attgtgaaat ccattgtcgc tcaaccgctg tctaggtgga ggtgcccgcg
1299841 cggttggcta attcggtgag ccaatacgaa gtcttgctgg tctgaagtgt ttggacaaat
1299901 gactcgtgga tcacatgggc ctggcgcgcg atcgccttgt acagctcgcc gtgcatggaa
1299961 aacagcatcg acgtcacgat ggacacaaga tcgtgggcgg gggattccac attggtgatc
1300021 agcggcgtga ccccgtcatc atgggcgctc atcgtcaccc cgatctcgtg gaggttggcg
1300081 gccgtttccc caatcgaatc gggccgtgtg gtgacaaaag acacgcgtgc atctccttcc
1300141 actgacgtgg tctgatggtg ggggtcagcg acgacttggg gttccgcacg gcattgtaga
1300201 cggaatcgtt cactaaggta ttttcaccat aacggcttcg gtcacaaaac ggtagcgatt
1300261 ctgttgagga attttttcga cgctcgcccg gtagggtgcc tccatgtctg agacgccgcg
1300321 gctgctgttt gttcatgcac accccgacga tgagagcctg agcaacggcg caaccatcgc
1300381 gcactacacc tcccgtggcg cacaggtcca tgtcgtcacg tgcaccctgg gtgaggaggg
1300441 cgaggtcatt ggcgatcgct gggctcaact caccgccgat catgcggacc aactcggtgg
1300501 ctaccgcatc ggcgagctca ccgcggcgtt gcgagcgctc ggggtcagcg caccgatcta
1300561 ccttggcggc gcgggtcgct ggcgcgactc cggcatggcc ggcacagacc agcggagtca
1300621 gcggagattc gtcgatgctg acccccggca gaccgtcggg gcattggtcg cgatcattcg
1300681 cgagctgcgg ccgcatgtcg tggtgaccta tgaccccaat ggcggttacg gtcatcctga
1300741 ccacgtgcac acccacaccg tcactaccgc cgcggtggcc gcagcgggtg ttgggtccgg
1300801 taccgcagat caccccggcg acccgtggac ggtgccgaag ttctactgga cggtcttggg
1300861 tctgagcgcg ctcatttcgg gcgcgcgagc cctggtcccc gacgatctgc gacccgaatg
1300921 ggtgttgccg cgggccgacg agattgcatt cgggtactcc gacgacggta tcgacgccgt
1300981 cgtcgaggcc gatgagcagg cgcgagccgc caaggttgcg gcactggctg cccatgccac
1301041 ccaagttgtc gtcggcccga ccggccgggc cgccgccttg tcgaacaacc tggcactgcc
1301101 catcctggcc gatgagcatt acgtgctcgc cggcggctcc gcgggcgccc gcgatgaacg
1301161 tggctgggaa actgatctgc tcgccggtct gggcttcacc gcgtccggca cgtaggctgc
1301221 caaccaggca gccacggaag gaaccccatg gaccccgacc tggaccctaa cctgcagcat
1301281 tggcaggacc gactcgacag cctgcagtgg gtcatcgggt cgatactctc tcagatcgac
1301341 agcgtgccaa cctgaccacc ggcgcgacag atcgagcaat ccgtttggtt gtcctggccc
1301401 tgttgactgt cgacggggtc gtgtctgcgc ttgccggggc tctgctgatg ccctggtata
1301461 tcggctcggc tccgtttccg atcagtgcct tgatcagtgg attggtcaat gctgcgctgg
1301521 tgtgggccgc agcgcgatgg accacatcgt cgcgggtggc cgcgctgccc ctgtgggcgt
1301581 ggctactgac ggtagcggcg atgagcttcg gcggccctgg cgacgatgtc attctgggtg
1301641 gccagggcct gctggtctac ggcgcgctgg tgttcgtcgt ggcaggggcc gtgccaccgg
1301701 cgtgggtgct gtggcggcgc agggtccaag ctgacggatc tggctagtcc gaagttaggg
1301761 caaagacggg aatcccggcg ggctgattgg cggcaacggc ggcaggaagc cgcgtatcca
1301821 gttgatctcg gtgttgatga attggttgat cgatgccgcg gtggccgttt cgatattggt
1301881 tagtgcctgg ctgaaagtga ctgtcccgtc cacgaagtcg atcgcattga acaggactgc
1301941 ctgcacgatg ggctcgccga ggtaatagaa gaagttgatc tgcggtgcca gtatgccgat
1302001 gtagggcagc catcccaccg cccatgcggt gaggttgaag ccgtactgca cccacggttc
1302061 gacggcgttg tagagattct tgattgcgtt gccgatcgac tcggcggcca gagccggcag
1302121 cgccgcggcg gcggccgctc cggcgcgcgg cagcagggcg ccgacggcgg acaaaccgct
1302181 ggccccaccg gtgggttgga gctgcagtgc accgctggca gcggcatttg cagcggcgct
1302241 accgccaagt gcactggagc cgccagtgcc gaggaacatg ctttggaccc ggctcagcgc
1302301 gttcgagccc ccacccgtcg aggcgtcggc gctaatcagt ggatgcccca gcaacgctct
1302361 tgcgggcgca ttcacggcgt tcaccatggt ctgcgcggcg ctggcctcgg cggttgcata
1302421 cgcgtctgca cttgctctca gcgcctgcac gaactggtcg tggaaggctg tcatcatctg
1302481 ccggctgagc tgctgatacc cctgagcatg cgcggaaagc agcgcggcga cctgagtcga
1302541 gacctcgtcc gcggctgcgg ccaggactcc ggtggtggga accgccgcaa ccacattggc
1302601 ggcgttaaga gtcgaaccga taccggccat gtccgcagcg gccgccgcca gtgcctctgg
1302661 cgccgcgaac acaaacgaca tctcgtacct tctcctggtt caccacgcgg cggctgtcgc
1302721 cgggggcttg ttcagacgct ggcctctcac ggatggtatc gcgatcggct gtgacctgcg
1302781 ccttactcca ccaaaccgtt ggtgccggac ggtcgacggc gtgccgagct cggcctggcg
1302841 ctactgttgc gcttatggcg ccaaggttgg ccagcatctc acctggtggg gcgtgcggat
1302901 gatatcagat tgcagggaag gtataccaac gtgccgcagc ctgtaggtcg gaagtccacc
1302961 gctctgccga gtcccgttgt accgccccag gcaaatgcct cagcgttgcg gcgggtactg
1303021 cgacgggccc gagatggtgt cacgctgaac gtggatgagg cggccatagc gatgaccgca
1303081 cgcggtgacg agctggccga cctgtgcgcg agcgccgcgc gggtgcgcga tgcgggtctc
1303141 gtgtcggccg gccggcacgg gcccagcggc aggttggcga tcagctattc gcgcaaggtg
1303201 tttatcccgg tcacccggtt atgccgggac aattgccact attgcacgtt cgtcaccgtg
1303261 ccgggcaagc tacgcgccca aggttccagc acgtatatgg aacccgacga gatcctcgac
1303321 gttgcccgcc gaggtgccga attcggttgc aaggaagcgc tattcactct cggtgaccgt
1303381 ccggaggcgc gttggcgcca ggcacgcgaa tggctcggcg aacggggcta tgactccacg
1303441 ttgtcctacg tgcgcgcgat ggcaatccgt gtgctggagc aaaccgggct gttgccgcac
1303501 ctgaacccgg gtgtgatgag ctggtcggag atgtcgcggc tcaaaccggt ggcgccgtcg
1303561 atgggcatga tgctggagac gacctcgcga cggctgttcg aaaccaaggg gctcgcccac
1303621 tacggcagcc ctgacaaaga cccggcggtg cggctgcgtg tcctgaccga cgccggccgg
1303681 ttgtccattc cgtttaccac cggtctgttg gtcggcatcg gcgagacgct atccgagcgc
1303741 gccgatacgt tacatgcgat tcgcaagtcg cacaaggagt tcgggcatat ccaagaagtg
1303801 atcgtgcaga acttccgcgc caaggaacac accgcgatgg ccgccttccc cgatgccgga
1303861 atcgaggatt acctggcgac ggttgcggtg gcgcggctgg tgctgggccc gggcatgcgc
1303921 atccaggcgc cgccgaacct ggtgtctggc gacgaatgcc gggcgctggt tggcgccggg
1303981 gtcgacgact ggggcggtgt ctcaccgttg acgcccgacc atgtcaaccc cgaacggccc
1304041 tggcccgctt tggacgagct ggcggcggtc accgccgaag ccggctacga catggtgcag
1304101 cggctgaccg cgcaacccaa atacgtacag gcgggcgcgg cgtggatcga cccgcgggtg
1304161 cggggacatg tggtggcgct ggcggatccg gcgaccggcc tggcccgcga cgtcaacccg
1304221 gtgggcatgc cgtggcagga gcccgacgac gtggcgtcct ggggccgggt cgatctgggc
1304281 gcagcgatcg acactcaggg ccgcaatacc gcagtgcgca gcgacctggc cagcgccttc
1304341 ggtgactggg aatcgatccg cgagcaggtg cacgagctgg cggtccgcgc tccggaacgc
1304401 attgacaccg atgtgcttgc cgccctgcga tcggcggagc gtgcgcccgc cggctgcacc
1304461 gacggcgagt atctggcgct tgccaccgcc gacggtcctg cgctggaagc cgttgccgca
1304521 ctggctgatt cgttgcgccg cgatgtcgtc ggcgacgagg tgacctttgt ggtcaaccgt
1304581 aacatcaact tcaccaacat ctgctacacc ggttgccggt tctgcgcgtt cgcccagcga
1304641 aagggtgacg ccgacgccta ctcgctgtcg gtcggagagg tcgccgaccg ggcatgggag
1304701 gcccacgtcg ccggggccac cgaagtatgc atgcagggcg gtatcgatcc cgagctaccg
1304761 gtcaccggct acgccgatct ggttcgtgcc gtcaaggcgc gggtgccctc catgcatgtg
1304821 cacgcgtttt ccccgatgga gatcgccaac ggcgtcacca agagcgggct gagcattcgc
1304881 gagtggctga tcggcctgcg cgaggccggg ctggatacca tcccgggtac cgccgcggaa
1304941 atcctggacg acgaggttcg ctgggtgctg accaagggca agctgccgac gtcattgtgg
1305001 atcgaaatcg tgacgaccgc ccacgaggtg ggtctgcggt catcatcgac gatgatgtac
1305061 gggcatgtgg acagtccacg gcactgggtc gcccatctta acgtgctgcg cgatattcag
1305121 gaccgtaccg gcggcttcac cgagttcgtc ccgttgccgt tcgtgcacca gaattcaccg
1305181 ttgtacctgg ccggtgcggc gcgccccggg cccagccatc gcgacaaccg cgcggtacat
1305241 gctttggcgc ggatcatgtt gcacggccgc atctcgcaca ttcagaccag ctgggtgaaa
1305301 cttggagtgc ggcgcaccca ggtgatgctc gaaggtggcg ccaacgacct gggcggcacg
1305361 ctgatggagg agaccatctc gcggatggcc ggttccgaac acggatcggc caagaccgtc
1305421 gctgagctgg tcgcgatcgc cgaaggcatc ggccgcccgg cgcgccagcg cactaccaca
1305481 tacgccctgc ttgcggccta gccccggcga cgatgccggg tcgcgggatg cggcccgttg
1305541 aggagcgggg caatctggcc tagccccggc gacgatgccg ggtcgcggga tgcggcccgt
1305601 tgaggagcgg ggcaatctgg cctagccccg gcgacgatgc cgggtcgcgg gatggggccc
1305661 gcatgggctt aatagttgtt gcaggagccg gcaaccgact cgacaaggcc gatgtactgt
1305721 gccgcccccg gcacagcttg caattgcgcg gccatggcag cgcgctgagg tggcggtgcg
1305781 gcgaggaaat tgcgcaaata ggactgcgcc accggtgagg cgttgaactg tgcggcagcc
1305841 cccggatccg tcgcgttgag cgcagctact acctgcccgt aattgcaggt ggtgttaatg
1305901 accgcgtcca cgggatctgc ggaggcgacc ccggccccga cggtcaacga cattgccacg
1305961 gcgcctacac cggcgctcaa tgcggtcaac gacagcctca tttatggaca ccttccccaa
1306021 actattgcac cgtcgttaag acggcgacga catctgccca gcggttgccg tctgcggtcg
1306081 agggtaccag gcgccgtggg cttgcttctc tcaaactggt tatcgggcga cactgcgcgg
1306141 ccataccaat ctgcaggtca gcagcgatga aacaacgttg tttacagccc gagaaatgag
1306201 tttatagcct ggccgcaagt tcggtgcctt gcttgatggc gcgcttggcg tccaactcag
1306261 cggcaaccgc cgcgccaccg atgatgtgcg ggttaatgcc gtgccggcgc agttcactct
1306321 ccagatctcg caccggttcc tggccggcgc agaccactac gttgtccacc gccagcagct
1306381 ggggccgcct gcgcttcggg ccgaagctga tgtgtaggcc gtcgtcgttg atctgttcgt
1306441 agttcacccc agacagctga tgaacgccct tggccttcaa cgacgcccgg tggacccatc
1306501 cggtggtctt gccgagccgc ttgccctgcg ggcctttggt gcgctgcagt aggtacacct
1306561 cacgggcggg cggcgccggc agtggagtcg tcaacgctcc gcgggcttct cgcggatcag
1306621 cgacccccca ttcggccttc cactctttga ggttgagggt gggtgaggag tcggtgacca
1306681 gcagttcggt gacgtcgaag ccaatgccgc cggcgccgac gacagccacg gttcgcccga
1306741 ccggtctgac accggtgatg gcttcggcgt aggttaacac catggggtgg tcgatgccgg
1306801 ggatggccgg aatgcgcggt gccacgccgg tggccaagac gacctcgtcg tagccggtca
1306861 actcctgggc ggccacccga gtgcccagtc gcacctcgac accgtgtttg gccagaatcg
1306921 tcgagaaata ccggatggtt tcgctgaatt cctctttgcc gggaatgcgg cgggccatgt
1306981 caaactgtcc accgataaag tcgttggcct cgaacagcgt gacccggtga ccccgttgcg
1307041 cggcgttggc cgccgtggcc agcccggctg gtccagcccc gacgacggcc accgagcggg
1307101 cgcgccgggt cggggacagc accaactgcg tctcgcgccc ggcgcgtgga ttgagcagac
1307161 acgacaccgt tttcctggca aatgcgtggt ccaggcaggc ttgattgcag gagatgcagg
1307221 tgttgatttc gtcgacccga ttggactgcg ccttgagcac ccagtccggg tcgctcagca
1307281 tcggccgggc cattgatatc agccgcacct gggtttcggc cagaatccgt tccgcggcct
1307341 gcggcatgtt gatccggttg gacgccacca ccgggatagt gacgtgttcg gcgacggcgc
1307401 tgctgatgtc gacaaacgcg ccgcccggca ctgaggtgac gatagtgggc acccgggcct
1307461 cgtgccagcc gaagccggag ttgatgatgg ttgcgcctgc cccttccact tcggttgcca
1307521 gcgcgacgat ttcatcccaa ctctggcctt ctgcaacgta gtcggccatt gacagccggt
1307581 aacagatgat gaagtcgcat ccgacggcgg cgcggctgcg tcggatgatc tcgaccggga
1307641 accggcgacg gttggccggt gtgccgcccc acgagtcggt gcgcttgttg gtgcgcggcg
1307701 ccaggaactg attgagcaga tacccttcgc tgcccatgat ttcgacgccg tcgtagccgg
1307761 catcgcgggc caactgcgcg cagcgggcga aatccgcgat ggtcgcttcg accccgcgag
1307821 ccgatagtgc tcgcggacga aacggggtga tcggcgcctt gatcggcgag gcgctgaccg
1307881 caagtgggtg gtaggcgtag cgtccggcgt gcaggatttg cagcaggatc tttgcacccg
1307941 aatcgtggac cgccctggtg attcggcggt gccgtcgggc ttgcgccgaa gtgacgagtt
1308001 cggaggcgaa cggcagcagc catccggtgc ggttgggcgc gtagccaccg gtgatgatca
1308061 gcccgacgcc gccgcgtgca cgttcggcga agtagtcggc gagccgatcg atatggcggg
1308121 cccggtcttc cagtccggtg tgcatcgaac ccataaccac ccggttgcgc agcgtggtaa
1308181 acccaaggtc caacggggac agcagatttg ggtatggatt tgtcatcgct tctcctggag
1308241 cgcttcagct acttcgtcga gccaatcgat ggcactttct tcggctcgga ttccgccgcg
1308301 cagcacgagg tattgatgca gtgcggcgcc atcgagcgcc gacggatctg cgaaggtgcg
1308361 cttctcgata ccgcgatagg tgtccagtga cttgacacgc tcggcgcgca gcgcggtgac
1308421 ttgggtatac agcgcggcaa cgtctccgta gccggcgcca cgcagcttga cggcgatatc
1308481 gcgcgtgctg ctgtcggtca gcgcactgcc gcggccgggc ctggtcgggc tgagcggctc
1308541 ggcgatccag cgagccagct cggcccggcc gctgtcggag atcgcgtata ccttcttgtc
1308601 gggccggcca tgctggagca cggtcgtcgc gcgcacccag ttgttgttct ccatcacccg
1308661 taacgtccga tagatctgct gatgggttgc ggtccagaaa tagccgatgg agcgatcgaa
1308721 tcggcgggcc aactcgtagc ccgagctggc ctgttcacac agcgacacca agatcgcgtg
1308781 gggtagcgcc atccgggcag catagacggc aagccggatt gctatgcaac taggtgcata
1308841 ttgaccgtgt acgccgacgc atgtgccaag tggtcgacgt gtatgtgcaa cgtctagtat
1308901 cagtaaccga acgcattgcc tcagcagggc ccggaggaag ccttggcgag gtggacagca
1308961 gcccacacat agcggtatct ggaagacatg ttgaggagac gtccgtgacg tacacgatcg
1309021 ccgaaccctg tgtcgacatc aaggacaagg catgcattga ggagtgcccg gtcgattgca
1309081 tctacgaggg cgcccggatg ctgtatatcc accccgacga atgcgtcgac tgtggggctt
1309141 gcgagccggt ctgccccgtt gaagctatct tctacgaaga cgatgtgccc gaacagtgga
1309201 gccattacac ccagatcaac gccgatttct tcgccgagct gggatcgccg ggcggtgcgg
1309261 ccaaggttgg catgaccgag aacgacccgc aagcggtcaa ggatctggcg ccgcagagcg
1309321 aggacgcctg agccggctgg gggcagcacc cgctcgcggc ggagtgtcgg cgtctctgcc
1309381 cgtcttcccc tgggacacct tggccgacgc gaaagcgctg gccggggccc atccggatgg
1309441 catcgtcgac ctctccgtcg gcactccggt cgacccggtc gcaccgctga tccaggaggc
1309501 gctggcggcg gccagtgccg cccctggcta tccggcgacc gccggcaccg cacggttacg
1309561 tgagtctgtg gtggcagcgc tggctcgccg ctacggcatc accaggctga ccgaggcggc
1309621 cgtgttgccg gttatcggca ccaaggaact catcgcctgg ttgccgacgt tgttgggcct
1309681 gggcggtgcg gatctggtcg tcgtgcccga attggcatat ccgacttatg acgtcggcgc
1309741 ccgcctggcc ggaacgcggg tgctgcgtgc ggatgcgctg acccagctgg gtccgcaatc
1309801 cccggcactg ctctacctga actcgccgag caacccgacc ggacgggtgc tgggtgtcga
1309861 ccatttgcgc aaggtggtcg agtgggcccg gggcagaggc gttctcgtgg tttccgacga
1309921 gtgctacctg ggattgggct gggacgccga accggtttcg gtgctacatc cctcggtgtg
1309981 cgacggcgac cacaccgggt tgctggctgt gcactcacta tcgaagagct catcgctcgc
1310041 cggctaccga gcgggtttcg tcgtcggtga cctcgagatc gttgccgagc tactagcggt
1310101 gcgcaaacac gccgggatga tggtgccggc gccggtacag gcggctatgg tggccgcgct
1310161 ggacgacgac gcgcacgaaa ggcaacagcg ggagcgctac gcacaacggc gtgccgcgct
1310221 gttgccggcg ctgggctccg cgggttttgc ggtcgactat tcggacgccg gattgtatct
1310281 atgggccact cgcggcgagc cgtgccgcga cagtgccgcg tggctggcgc agcggggcat
1310341 cctggtggca ccgggtgatt tctacggccc gggtggggct cagcacgtgc gggtggcgct
1310401 gacggccacc gacgagcggg ttgcggcggc ggtcggacgg ctcacctgtt agcgcgaaca
1310461 gacgcaactt gcggccgggt caccgccagg tcgtgcgcag ctgggttgtc accgagagcg
1310521 ggttatcgcc gcggaacaga tcgaggatgg cttgcccttg tggggagtct gctggcagtt
1310581 gtcggggtgg gccgatgtgc tttcgccatg cctgtgccag atgttgccgc cgatccttgt
1310641 ttcgtgcgaa ccagcggggc acggcgtgcc aggcaaccgt gccgggcagc gatagcccga
1310701 cgacggcacg aaccgcgaac agcctccggg caacgggccg ggcgggcggc gtgaggatct
1310761 tgcgtccgat gaggtagcgc ggttcggcaa gcggcgccag tagctcgtcg agggccgcgg
1310821 tgaaccgcag ggactgctcg gtgggcacgc cgtcgagttg acaccggatc cagccttcgg
1310881 ggtcggaggc caaccgtagt gccgcggatc ctcgctgtgc gccgcccgcg gcgtacagcg
1310941 catccgcgac gacggcggcc agttgctcga gcgcgttggg cgcgtggtcc aggcggcggc
1311001 tttcggccgc cgcagcggtt gccaccaggc caacacccgc cgcgacgatg gcgccggccg
1311061 tgccggcacc cgccagcatg ccgagattgg cggaggcaac tgcggtggcg gtgctggcgc
1311121 cgaccacgga aacggcggcc acggcacccc ttgccaggcg gaccggactg aactgtcccg
1311181 gcaccggtgg ggtcaatgcc gaggcgggga tgcggggtgc ggcgaccccg agcggctggc
1311241 gggagcgcac gcggatggtt gcgacgtcga ctccttcgta gggctcgccg attcgccacc
1311301 aggatctcgc ctgggcgcgt tcggcgacgc gctgcagcgc tcgcgccgtg atggcgtggg
1311361 tatcggtgac cggaggaccg tacggcgaca gcgacggatc gcagtgcgtc acacccgatt
1311421 cgatgagccc ctgcggggtt gccgcgtagt acccgtcatg tttgcgcacc aggcgcaggt
1311481 agtcggcatc accgcgcggg tgttctgtgg cgatacagca gaccgaccag ttgtccgcca
1311541 ccttgtgacc gtccgagggg tcgttgcgga tggcgcggcc gcgcatctga gtgatcgctg
1311601 cctgggtggt tgcgctcgtc aggtcgatat tgacgttgac cgccgcgcag tcccaccctt
1311661 cacctagtag cgaacgggtg ccgaccagga cgcgggcgcg gccggccagg aagtattcgg
1311721 tagccagcgc gacccacgta cgtggcgtga agccgccggt gccgcgcatg acccgcagac
1311781 tagggtgggc gtcaagcggc tcggcggtga cgagcgcgcc gcgctcggcg cagaaggcga
1311841 tcaggtcatc ttcgatcgcg gccgggcagg cgaaggtttg acctgttacc agaagggcgt
1311901 gcagtggggt gcggcggcgg tgatccgacg cggcgagcat ggcggcaacc agctgggccg
1311961 aacccgactg ctcgctgacg ggtgcgccct tcagcgatgt gggaagggcg ccggtcatcg
1312021 attcgaaatc gcagagcacc agcgcccgca accgcgcccc caagacggcg tcctcggtgt
1312081 cgaggatgtg cgcggtcgcg gcgatcttgg attcggacag cgcgcacagt ctgtctactg
1312141 gcgaggtcgc gacgcgtacg ccgcgactgg tcagccggta gcccaggccg ggtagcaccc
1312201 gcttgatcgc ggtcagcgcg tgcgcgtcgc gcggatccgc gctttgttgc aggtgcccga
1312261 cgctgaagtc ggtcaatacg ttaacccagt cctgggcatc gggcgcaatt cggtgctgct
1312321 cgcgcaggcg cacgccgtcg ggtagtggaa tcaggccgtc gtaggcgaag cgcaggccgc
1312381 tgcacgcgag gtcgggttcg gcacgctcga acgtcgacca ggcgatctga ttgccctcgc
1312441 gcgtcgctcg atccacgatc cgggtgtgca gccacgcggc caacgacatg ctgcccacct
1312501 tttggtcgat gagggccagc atgaggtcgg cgaagcgcgc ccggtgggtg ccgatccagg
1312561 cctgctcttc gggcgtcggt tgggtcagat agaccaactc ttggtaggga gccaggtcgc
1312621 cttccctaac cagagcgggt gtcgggatca cgaagtcggc ggtgccgaac agctcatcat
1312681 gcagggtgtg ctgccacgcg gtgagctctg tggccggggt cgccgttaga ccgatcagcg
1312741 cggtctgcgc tccgaggacc gacgccaacg cactgaccag ggcgccccac gtagctagca
1312801 gatggtggca ctcatcgagc accagcgtcc acgggcctag cgtcgccgcc cgctcgatca
1312861 ccgccctccc gttggggtgc aggagatcca gcaacgcttg ctggtcgcgg ttgcgcagga
1312921 cttcccgccg gactgtcgaa tcggtttcgg cgtcgatgac ggcaagcgac tgatacgtca
1312981 ggacgttcat cgccgaggca aggccacgct cggttccaca cttcgatgcc gaccggtccg
1313041 acgacggaaa actgttatcc cacgcggcgg cccactgcgc ctgcaccgcc gtgttgggaa
1313101 ccaacaccaa actccggcgc cccagccggc gcgctgcttc caggccgatc atcgtcttgc
1313161 ccgcacccgg cggcagcacc agataggcac ggttgtcgcc ggcagcgacg tcggcgtcga
1313221 acgcgtccaa cgcttgctgt tggtataccc gccagttgcc ggcaaaggcc cgcgattcca
1313281 ggtcgcggtg aggatccaca aggattcacc ctagccaagc acccacgttg ggcgcgaaag
1313341 acgcaaaagg ccccgaatcc aacggatttc ggggcctttt gcgtctgctc gcgcccgtgc
1313401 ggctcgtgcg gatcacacgc gcggtgcatg ctgctgtggc tgtcgagcag tgttgctacc
1313461 ttaactttcc caggcctacg acgtctggta gcggcatggc aacggcctgt gagttggctg
1313521 gataatgtgt tcttcgtcgt gctgtggcct gcagattaac aagtcccaca acagttttcc
1313581 cgttgtatcg gaccttgcag catgcgatgc tttcgtcttg agccactacc atgaagttag
1313641 tacgctaaac aatcctgagc ccgaatgtgt tggtaaatgg ggtttgggag cattcaccca
1313701 cggctggtac agggggactg cgtagtgcgc accgcaaccg ccacatcggt cgccgttatc
1313761 ggcatggctt gccggctccc gggcggcatc gattccccac aacgcctctg ggaagcgctg
1313821 ttacgcggcg acgatttggt gggtgagatt cccgctgacc ggtgggacgc gaacgtgtac
1313881 tacgaccccg aacctggtgt ccctggtcga tcggtatcgc gttggggcgc ctttctggac
1313941 gacgtcggcg ggtttgactg cgatttcttc ggcctgaccg agcgggaggc gaccgcgatc
1314001 gacccacagc accgcttgct gctggaagtg tcgtgggagg ctatcgagca cgcgggtgtg
1314061 gacccggcga cgctcgctga atcacaaaca ggtgtcttcg taggactgac acacggcgac
1314121 tacgagctgc tgtccgcgga ttgcggcgcc gcggaaggac cgtacggatt caccggcacc
1314181 agtaacagtt tcgcgtccgg gcgagtggcc tacacactcg gactgcatgg ccccgcggtc
1314241 acggtggaca ccgcgtgctc gtccgggttg acggctgtgc atcaagcctg ccgcagcctg
1314301 gatgacggtg aaagcgatct cgctcttgcc ggtggtgtgg ttgtcacgct agaaccgcgg
1314361 aagtccgtct cgggttccct gcaaggcatg ttgtcgccta ccgggcgttg ccatgccttc
1314421 gacgaagcag ctgatggctt cgtgtccggt gaggggtgcg tggtcctgct gctgaagcgg
1314481 ctaccggatg cggtgcgcga cggtgatcgt gtgctggcga tcgttcgtgg caccgcagcc
1314541 aaccaggatg gccgcaccgt gaatatcgcg gcgccgtcgg cgcaggctca gatcgcggtg
1314601 tatcagcaag cgttggctgc agcgggcgtc gaagcgtcga cggtggggat ggtcgaagcc
1314661 cacggcaccg gcacccccgt tggagatccg gtcgaatacg cgagcctggc cgcggtgtac
1314721 ggaaccgagg gtccgtgcgc gctgacgtcg gtgaaaacaa acttcggtca cctgcagtcg
1314781 gcatcggggc ccctggggtt gatgaagaca atcctggcgt tgcggcatgg ggttgtgccg
1314841 cagaacctgc acttctgccg gctgcctgat cagctggctg agattgacac tgaactcttt
1314901 gtgccgcaag cgaatacatc ctggccggac aacaccggac agccacgtcg cgctgcggtt
1314961 tcctcgtatg gaatgtcggg taccaacgtg catgccatct tggagcaagc gccggtatca
1315021 gaaccagcgg cttcgggacc tgagctcact cccgaagccg gtgggctggc gttgtttccg
1315081 gtgtcggcta cctcggctga gcaactacac gtcacggccg cccggctggc ggattgggtc
1315141 gaccagaacg gcaacgcggg cagtcgagtt agcatgcggg acctgggcta aacgctgtcc
1315201 tgccgccgtg cacaccgacc cgtccggacg gttgtgacgg cgagcagttt tgacgagctg
1315261 agcgcggcgc tgcgggacgt cgctggcgat cagattccct atcagcccgc agtggggcac
1315321 gacgaccgcg ggccggtgtg ggtgttctcc gggcaaggct ctcagtggcc cgggatgggc
1315381 actgaactgc tggtagccga accggtgttc gccgccaccg tcgcggcgat ggagccggtg
1315441 atcgctaggg agtcagggtt ttcggtgacc gaagcgatgt cggcgccaca gacggtcagc
1315501 ggtattgacc gggtgcagcc caccatcttc gcggtgcagg tcgccctggc cgcggccctg
1315561 aagtcgtatg gggtacgtcc tggtgccatc atcgggcact cgctcggcga ggctgcggca
1315621 gccgtggtcg ccggagcact gtcgctgcac gacggattgc gagtcatctg ccggcgctcg
1315681 cggctgatgt cgcgcatcgc cggtagtggc gcgatggcat cggtggaact gcccggccaa
1315741 caagtgttgt cagaacttgc gattcgtggg atctccgacg tcgtgctctc ggtggttgcc
1315801 tctccgacct caaccgtcgt cggcggcgcc acgcagtcga tacgtgacct ggtggcggcc
1315861 tgggagcagc aggatgtgct ggcgcgcgag gtagctgtgg acgtcgcttc acatacaccg
1315921 caggtcgatc ccatcctgga cgagttgctc gaggtcctgg ccgaggtcga tccgacggcg
1315981 ccggaaattc cgtattactc cgcaacgttg tgggatccgc gcgagcgacc gtcgttcacc
1316041 ggcgagtact gggtggaaaa cctgcggtac acggtgcgat tcgcggcggc ggtacaggcc
1316101 gcgctcaagg acgggtaccg agtgttcggc gagctggctc cgcatccgct gctcacctac
1316161 gcggtcgagc agaacgccgc cagtctcgac atgccgatcg caacgcttgc cgcgatgcgg
1316221 cgcggggaac agctgccgtt cgggttgcgc ggcttcgtcg ccgacgtgca caacgccggc
1316281 gccaaggtgg acttctctgt ccagtaccct gatgggcgct tggtggatgc gccattgccg
1316341 agctggacgc accgcaccct gatgctcagc cgtgaggatt cacaccgctc gcacaccggc
1316401 gcggtccagg cggttcatcc gctgcttggg gcccatgtgc acctgttgga ggaaccggag
1316461 cgtcacgtct ggcaggccgg ggttggcacc ggggcgcatc cgtggctcgg tgaccatcgg
1316521 atacacaacg tggctgcgtt tcccggtgcg gcctactgtg agatggcatt ggccgcggcg
1316581 cgcaccactc ttggcgagct gtcggaggtg cgcgacatca agttcgagca gacgctgttg
1316641 ctggacgagc agacggtggt ctcatcggcc gcgacgatcg ccgcgcctgg gatcctacag
1316701 ttcgcagtcg agagtcatca ggaaggcgag cccgcacggc gggccagcgc gatgctgcac
1316761 gcattggagg agatgccgca gccgcccggg tacgacacga acgctctgac cgccgcccat
1316821 gagtccagca tgagcggtga ggaactgcga aaaatgttta acagcttagg tattcagtat
1316881 ggtccggctt tttcaggcct agttgcggtg cacacggcgc gcggggacgt caccacagtg
1316941 ctcgccgagg tcgcgctgcc tggagccatc cgatctcagc agtcggcata tgccagccac
1317001 ccggccctgc ttgatgcgtg tttccagtcg gtgcttgttc atcccgaggt ccagaaggcg
1317061 actgtcggtg gtctgatgct gcccgtgggc gtgcgtaggc tgcgcaacta tcactcgacg
1317121 cgcagcgcgc actactgcct cgcccgggtc acgtcatcgt cgcgagccgg cgaatgcgaa
1317181 gccgatctcg acgtgttcga ccaggccgga acggtacttt tgaccgtcga gggattacgg
1317241 ctggccgcag ggatttccga acatgaacgc gcgaaccggg tgttcgacga gcgattgttg
1317301 accatcgagt gggagcgggg tgagctgcct gaggtgccgc agatcgatgc gggatcctgg
1317361 ctgctgctca gtgcgtccga agctgatccg ctgaccgcgc aactcgccga cgcgttgaat
1317421 gccgttggtg cccagagcac tagcgtggct tcggcgtcgg atgtcgcaca attgcgttcg
1317481 ctgctcggag gcaggctcac cggtgttgtc gtggtgactg gcccgccaac gggtggtttg
1317541 acacagtgcg gccgcgacta tgtgtcacag ctggtgggta ttgcccgcga gctcgcggag
1317601 ctgcccggtg agccgccgcg gctgttcgtg gtgaccagga gcgcggcgag cgtgctgccg
1317661 agcgatcttg ccaacttgga acaggcggga ttgcgtggac tgatgcgggt gatcgattcc
1317721 gagcatccgc acctgggtgc caccgcaatc gacgtcgaca acgacgagac cgtcgctgcc
1317781 ctggtggcca gccaactaca gagcgggtcg caggaggacg aaaccgcttg gcgcaatggc
1317841 atttggtaca ccgcccggct gcgtcccggt ccgttacgcc cggccgaacg gcgaaccgcc
1317901 gtcgtcgaat acagacgcga cggtatgcgc ctgcagatcc gcactcccgg cgacctcgag
1317961 tcgttggagt tcgtcacatt cgaccgggtc gcgccgggac cgggcgagat cgaggtcgcg
1318021 gtgaccgcat cgagtgtcaa cttcgccgac gttctggtcg ctttcgggcg gtatcccacc
1318081 ttcgagggct accgacagca gttgggcatc gacttcgccg gtgtggtgac cgcggtcggg
1318141 ccggatgtca ccgagcatcg gatcggtgat cacgtcggcg gcatgtccgc caatggctgc
1318201 tggagcacat tcgtcagatg cgatgcccgg ctggcggtga cgctcccgcc cgagctgccg
1318261 gtggccgccg ccgccgcggt accgaccgcc tccgcgacgg cttggtacgc cctgcacgat
1318321 ctggctcgca tctgctcgga cgacaaggtg ctgattcact cggggaccgg tggtgtcggg
1318381 caggcggcga tcgcgatcgc acgggccgcc ggatgcgaga tcttcgccac cgcgggcagt
1318441 gcccagcggc gacaactgct gcacgacatg ggtgtcgagc atgtctacga ctcacggagc
1318501 accgagttcg ccgagcagat ccgaggcgac accgatgggt atggtgtcga cgtcgtactc
1318561 aactcgctgc ccggcgccgc acaacgtgct gggatcgaat tgctggcctt tggcgggcga
1318621 ttcgtggaga tcggcaaacg tgacatctac ggcgacactc ggctcgggtt gttcccgttc
1318681 cgccgcaacc tgtcgctgta tgccgtcgac ttggcgctgc tgacacacag ccacccgcac
1318741 accgtccggc gcctgctgaa aaccgtctac caacacacgg tcgagggcac gctgccggtg
1318801 ccgcagacca cgcactatcc cattcacgac gctgccgttg ccattcgttt ggtcggcgga
1318861 gccgggcaca ccggaaaagt ggtgctcgat gtgccgcgta ccggtgaagg cgtggccgtg
1318921 gtgccccccg aacaggtccg cacgtcccgg cccgacggcg cctatctcgt caccggtggt
1318981 ttgggcggcc tcggcctgtt ccttgccggc gagctggcgg cggcgggctg cggacgcatc
1319041 gtgctcaact cccgttcgac gcccagcccg cacgccacca gggtcatcga gcggctccgc
1319101 gccgccggtg ctgatatcca ggtggaatgc ggtgacatcg ctgatgccgc aacggcccac
1319161 cgagtggtgg cggtggccac cgcctcgggc ttgccggtgc gcggcgtgct gcacgcggcg
1319221 gcggtggtcg aggacgctac gttggccaat gtcaccgacg aacttatcga ccgctgttgg
1319281 gcgccgaagg tacacggcgc gtggaacatt catcgggcca ccgccgcgca gccactggag
1319341 tggttctgct tgttctcctc ggccgcggcc ttggtgggct cgccgggtca aggcgcatat
1319401 gcggcggcca acagctggtt ggacgctttt gcccactggc ggcgggcgca gggccttccg
1319461 gctacctcaa tcgcctgggg agcatgggcc gagattggcc gcgctaccgc gctggccgaa
1319521 ggcaccggcg cagcgatcgc gcccgccgag ggtgctcgag ccttccagac gctgcttcgc
1319581 tacggccggg cgtactccgg ctatgccccg atcatgggta ccccatggtt gacggccttt
1319641 gcgcaacgta gccgatttgc cgaagcgttc cacgccacgg gccaaaatca accggccacc
1319701 gggaaattcc tcgccgaact gggcagcttg ccccgcgaag agtggccccg cacagtcagg
1319761 cggttggtat cggaccagat cagcctgctg ctgcggcgaa ccattgatcc ggaccggccg
1319821 ctgtccgact atggtttgga ttccttgggc aacttggagt tgcggacccg catcgaaacc
1319881 gaaacgggta tacgcgtcag tcccacaaag atcaccacgg ttcgcggctt ggccgagcac
1319941 gtgtgcgacg agctggcagc cgcccaatct gcgccggtct gatgacggcc cgggtgaagt
1320001 cgttgcggaa gtttgagatc gagccgagga gggcatgttg cgggttggac cgttgacaat
1320061 aggcacgctg gacgactggg cgccgagcac gggttcgact gtgtcatggc gaccttcggc
1320121 tgtcgcgcac acgaaagcgt cgcaggcgcc gatcagcgat gttccggtca gttatatgca
1320181 ggcgcaacat attcggggct attgcgagca aaaggcaaag ggactcgact actcgcggtt
1320241 gatggtcgtc agctgccagc agcccggcca gtgcgatatc cgggcggcca actacgtgat
1320301 caacgcccat ctccgacggc acgataccta tcgcagctgg ttccaataca acggcaacgg
1320361 acaaataatc cggcgtacga tccaggatcc cgccgacatc gagttcgtac cagttcatca
1320421 tggtgagctc acgctgccgc aaattcgcga gatcgtgcag aacacgccgg atcccctgca
1320481 atggggttgt tttcggtttg ggatcgtgca aggctgcgac catttcacat tctttgcaag
1320541 tgtggatcat gtgcatgtgg acgcgatgat cgtcggtgtc acgctcatgg agttccacct
1320601 gatgtacgca gcgctggtgg gcggccatgc ccctctcgag ctaccgccgg caggcagcta
1320661 cgacgacttc tgccgccgac aacacacgtt cagctccacc ctcacggtgg agtcgcccca
1320721 ggttcgcgcc tggacgaagt tcgccgaagg tactaacggt agctttcctg attttccact
1320781 cccacttggt gacccatcga aacccagtga cgcggatatt gtcaccgtga tgatgctcga
1320841 tgaagagcag acggctcaat tcgagtccgt ctgcacggct gccggcgctc ggttcatcgg
1320901 tggcgtacta gcctgctgcg gcctggctga acacgagttg accggtacga caacctatta
1320961 cggactaacg ccgcgcgaca cgcgccgcac tccagcggat gccatgaccc aaggttggtt
1321021 caccggccta attccgatca ccgtccccat cgccggctcg gcgttcggcg atgccgcccg
1321081 agccgcgcag acctcgttcg actcgggcgt gaagctcgcc gaagtaccct acgaccgcgt
1321141 cgtcgaattg tcgtccacgc taaccatgcc acgaccgaac tttcccgtcg tcaacttcct
1321201 cgacgcaggc gcggctccgc tttcggtact gctcaccgcg gagttaaccg gtacgaacat
1321261 aggagtgtac agcgacggtc gctactctta tcaactgtcc atctacgtca tccgcgtcga
1321321 gcaggggacg gcagtggcgg tcatgttccc cgacaacccg atcgcccggg aatcggttgc
1321381 ccgctacctg gcaacgctga agtctgtgtt ccaacgagtc gccgagagcg ggcagcagca
1321441 gaatgttgcc tgattcattc ccggtggtga acccatcttc gcgcggctag gtgaactcgt
1321501 cgcccggcgg ccttgggttg tggtcggctg ttgggtcgcg ctcgccctgg tactgccgat
1321561 ggcggtgcct tcactggcgg agatggctca gcgacatccc gtcgcggtcc tgcctgccga
1321621 cgcgccctcc agcgtcgctg ttcgccagat ggccgaggcg ttccacgaat ccggctccga
1321681 gaatatcttg gtagtgctgc tcaccgacga gaaaggcttg ggagcggcgg acgaaaacgt
1321741 ctaccacaca ttggtggatc gtctgcgaaa cgacgctaaa gacgtcgtga tgctgcagga
1321801 cttcctgact actccgccat tgcgtgaggt gctcggtagt aaagatggca aggcatggat
1321861 tctgccgatc ggtctcgcgg gcgacctggg tacacccaag tcctaccacg cttacaccga
1321921 cgtcgaacgc atcgtgaaac gaactgtggc cggaaccacg ttgacggcaa acgtgacagg
1321981 acccgcagcc acggtggcag acctgaccga cgctggggct cgggatcggg cttcaatcga
1322041 gctggcgatc gccgtgatgt tgctagtcat cttgatggtc atctatcgca acccggttac
1322101 catgctgttg cccctggtga cgattggcgc atccttgatg accgcgcagg cgttggttgc
1322161 cggcgtgtcg ctcgtcggcg gtctagccgt atccaatcaa gcgatcgtgt tgctcagcgc
1322221 aatgatcgct ggtgcgggaa cggattacgc cgttttccta atcagccgct atcacgagta
1322281 tgtgcggctc ggtgagcatc ccgagcgtgc cgtccagcgg gcgatgatgt ccgtcgggaa
1322341 ggtgatcgcc gcgtccgcgg caacggtcgg aatcaccttc ctcggcatga gattcgccaa
1322401 actcggtgtg ttctcaacgg ttggcccggc tctggcgatc gggatcgcgg tgtcgttctt
1322461 ggccgcggtc accctgctgc ccgccatcct ggtgctggcc tcaccgcgcg ggtgggtcgc
1322521 accgcgcggt gaacgcatgg cgacattctg gcggcgggcc ggaacgcgaa tagtgcggcg
1322581 gcccaaagct tatctaggcg ccagcttgat tggtctggtt gcattggcca gctgcgcgag
1322641 cctggctcac ttcaactacg acgaccgcaa acaattgccg ccttcggatc cgagttcggt
1322701 tgggtacgcg gcaatggagc accatttctc ggtgaatcag actattcctg agtacttgat
1322761 catccactct gcacacgacc tgcgaacccc gcgcggcctt gccgacctgg agcagctggc
1322821 gcaacgtgtg agccagatcc caggcgttgc catggttcgc ggtgtgaccc ggccaaacgg
1322881 ggaaaccctt gaacaggccc gggcgacata ccaagccggc caagttggca accggctggg
1322941 cggcgcgtcg cgaatgatcg atgagcgcac cggcgacctg aatcggctgg catcgggtgc
1323001 caacctgttg gccgacaatc tcggtgacgt tcgcggtcaa gtcagccggg ccgttgcggg
1323061 tgtccgcagc cttgtcgacg ccctcgctta catccagaac cagttcggtg gcaacaaaac
1323121 attcaacgaa atcgacaacg ctgcaaggct tgtcagcaat atccacgcgc tcggtgacgc
1323181 tctgcaggta aactttgacg gtatcgccaa cagtttcgat tggcttgact ctgttgtcgc
1323241 cgctttggat accagcccgg tctgtgacag caaccctatg tgtggcaacg cgcgcgttca
1323301 gtttcacaag ctgcaaaccg cacgtgacaa tggcactctc gacaaggttg tcggcctggc
1323361 gcgtcagctg cagtccacgc ggtcaccgca gaccgtgtcg gcggtggtga acgatctggg
1323421 gcgatcgctg aattcggtag tccgctcgct gaaatcactg gggttggaca atccggacgc
1323481 cgcccgggcg cgcctgatca gcatgcaaaa tggagctaac gacctcgcca gcgccggtcg
1323541 tcaggtcgca gacggcgtcc agatgctggt cgaccagacc aagaacatgg gcatcgggct
1323601 gaaccaggcg tcagcctttc tgatggcgat gggcaacgat gcgtcgcaac cgtcgatggc
1323661 gggtttcaat gtcccgccgc aagtgctgaa gtccgaggag ttcaaaaaag tcgcccaggc
1323721 gttcatctcg ccagacgggc ataccgtgcg gtacttcatt cagaccgacc tcaacccgtt
1323781 cagcactgcg gccatggatc aggtcaacac gatcattgac acagccaaag gtgcacagcc
1323841 aaatacctcc ctggctgacg cgtcgatatc aatgtcgggt tacccggtca tgctgaggga
1323901 catccgcgat tactacgagc gcgatatgcg gctcatcgtc gctgtgaccg tcgtcgtggt
1323961 gatcctgatc ctcatggcac tgctgcgtgc gatagtggcg ccgctgtacc tggtcggttc
1324021 ggtggtcatc tcgtacatgt cggcgatcgg gcttggtgtg gtggtgttcc aggtgttcct
1324081 ggggcaggaa ttgcactgga gtgtgcccgg cctagcgttt gtggtgctgg tcgccgtggg
1324141 tgcggactac aacatgctgc tggcgtcgcg gttgcgggac gagtcggcat tgggagtgcg
1324201 ttccagcgtg attcgcacgg tgcgttgcac gggcggagtg atcacggcag cgggtctgat
1324261 atttgccgct tcgatgtccg gcctgctgtt ctccagcatc ggaaccgtcg tccaaggcgg
1324321 cttcatcatt ggggtcggga tcctgataga cacgttcgtg gtgcggacca tcaccgtgcc
1324381 tgccatggcc acgctgctcg gacgcgcaag ttggtggccc ggacaccctt ggcagcggtg
1324441 cgcacccgaa gaaggccaga tgtcagcccg gatgtcagcg cgcacgaaga cggtatttca
1324501 agccgtggca gacggatcaa agcggtagtg tttagccgcc gaaggcgggg gagcccagta
1324561 agccgcgggc accttccacg atcgagcccg gagcggtcag cggatccagg cctcgcaccg
1324621 gatccacgga gaccggccgg gtgaaccaat tgtcgttgcg tgcataggcc gcgtcgatct
1324681 gtggttgcag cacactgtcg atttgatcga cttcggcgtc ggacatgccg aggtaacgca
1324741 gcggcaaggt caacgggagg tggttcacgg ggaccagata cgtcgtcgtg gtagcgcctc
1324801 gtgagttgac ggtggtcctg atgttctgcg ggggtacgtc accgggtccg gtgaacccga
1324861 ttggggtgtg cgcgatggca gcgccgatgg ccgcattggc gaccgctaac agattgtccg
1324921 gccggtccgg gaagtcgctg aagccgtcgt atgcggtgac gacatggttg gtgtcgtact
1324981 ggctatccac ctgctggggc atcgtatatt cgatgaaggg aatcggaatg tggctaccgg
1325041 ggggaaaaat tcgggccagg aagctcgctc cgaacgcatg acgtccggtg gggtcgccga
1325101 acgtcgtgaa ctgcagcttg tccggtgcag gtgccgtcgg gtcgttggcg agccgcgcct
1325161 gctcctggtc gagcacgagg gaaccctggg ataggccgac ggccgcggct ggatcggttc
1325221 cgtgatgaat tgcgttatca aggctgtttg tcccatcttt gaccgccacg cccaccgtca
1325281 tgttgtcttg gtggctccct ggcggcaaaa gcatggtggg ccaccagctg aaggccgctc
1325341 cggcgggata gtcgatgaga tcgtgctttg cgtttgggaa atattgagag ccagcctggt
1325401 tcgtgtactc gtaccaggga atgcccggca ttcgcgcgcc cccgagggcg tagacgactt
1325461 tggcggttga agcgtcgccc accggagagg gggacggagg tggcccagga gcccacgggt
1325521 acgcgggttc gcttgccgca atagcggttc cgaatccacc ggcccaaccc acgagccaga
1325581 ccgcgaatgc tcccgcaatc actcgcttca tctgcctctg catcgagaat cgcgtgcgtg
1325641 aaagcatagg aaagcagcta tcgttcggcg gttttcgggc ggttatgtcg ccatatctta
1325701 gtcagccacg tcccggccga cattaaagtt ggcagccaac aagctgtgaa tcgccctggg
1325761 tcagccccga ctagctcagc cgtccaaccg ggtgaattgc tgcagccggt attgctctac
1325821 acaggcggcc cttctgatct tgccgctggt tgtggtgggg atcgacccgg gcgggaccaa
1325881 gacgaggtcc gccacgttga gaccgtgcga gcgtgatatc gcggctgtga cgttgttctt
1325941 gatgacatcg agttcgtcca tcgcttcgcc ggcggaatcg ccgaggagct tgagctcgat
1326001 gacagtgact aacttctctg tgtgatcgac cggaactgaa atcgcagcga cccgaccacc
1326061 agtgatctcc tggacggtcg actcgatgtc ctcggggtag tgattgcgcc cgtatacgat
1326121 cagcatgtcc ttcatacggc ccacgatgaa catctcgtcc tcggagagga atccgaggtc
1326181 tcccgttcgc aaccaggatc catcaggagt acctgccgag gggtggacca gcattgcgcc
1326241 aaaggtgtgc cgtgtctcgt ccggtttgtt ccagtagcct tcggcgacgt tgtcgccctt
1326301 cacccagatc tcgccgatcg ttcccgcggg gcactcaatg caggtgtcgg gatccacaat
1326361 tcgcactgtt ggtgatgtcg gcatgccata gctcagcagc ggtgtgccgg tcttgggttc
1326421 acatcgattc gcactgcccg tggacagctt gtcaggttcg aagtagacga cttctggctt
1326481 gtcacccgaa ttgcggctgg ccacataaag agtcgcttcc gccagaccgt acgaaggccg
1326541 tatcatgtct tcgcggaaat tgtacggtgc aaaccggttg cagaatctac tgagcgtgtt
1326601 ggggtggact cgttcagcac cactggtgat gcccaggacg ttgccgaggt cgaggccttc
1326661 tatgtcggca tctgttgtct tgcggacggc caattcgaag gcgaaattcg gtgcggccga
1326721 ccacgaagga cttccgttgg ccagcgaatg tagccaacgc gctggccgtt gcaggaacgc
1326781 cagcgggcta gtgagttcac tgcggtagcc gcccaggatc ggtgcgatga tgccaaggac
1326841 caagcccatg tcgtggtaga acggcagcca cgacacgatg gtagtgtcag gtggcgccac
1326901 accgttgcgg tcgccgaagt agttcgacat cagctgttgg aaattcgcct gaaggttccg
1326961 atgcgagatc atgaccccag ccggagcgcg ggtggagcca gaggtgtact gcaagtacgc
1327021 ggcgcttggc agatccttca cccgaaagct cggtgaattc ccggtcaagt ccaatgaatc
1327081 gatttcgatg atcggcccta cgttgttcgt gttcggccgg tggatgtgct cggcaaccgc
1327141 ttctgcgacc gcagatgttg tcaggatgac cgaaggtgac gcgtcggcaa gcaccgcgct
1327201 gacacgttcg tcgtgagagc cgatctgcgg gactgacaac ggaaccgcta tcgctccggc
1327261 ctgcatcgaa cctaggaaag ccgcgatgta ggccaggccc tgcggagcca gaatcacggc
1327321 tcggtctccg gtcgtgcaat gccgcctgac ttcgtgagca acgatgcggg tccgtcgaaa
1327381 cacctctgac cacgtgagcg tctcggtgat gccggcccaa tcctgttcgt agtcgatgta
1327441 cgtgaacgcg gcgtcgtcgg gctgcaggcc ggcacgctcg cgcagcaagg acaagacaga
1327501 agagtcggac attggtgcta cattaccgtt tcgcgcgatc tccgataacc caagcgggca
1327561 gggggatggt tggcgatagc gatgctgatc ataacgttct gcaatgctgt gcatgtgctg
1327621 aaacaggttg acgcagagtc gaagtcggtg tacgcagggg cgccgtgagg ggcgtcacgg
1327681 tcgagttgct aagccgtgcg ttccatggcc cgcagcccca gcgaaaagag cagccgcaca
1327741 tccggatcgc ccagcgaggt cgacaacagc tgctcgatcc gccttatccg gtagcgaacg
1327801 gtgttgggat gcacttgcag tgaccgtgcg gcggcgccga tgtcgccgaa ggcatccagg
1327861 taggcacgca gggtctgagc cagcaccggg tcctgggcgc ccaggtcacg tatccgagga
1327921 tcgacgagcc gctggtcggt gccgaccagg gtgacgattt cgtcgagcag aacggtggtg
1327981 cgtgcctcgg ccagcgatgt cacctgcccc aagatcgggt ggcgctcggc actctcgagt
1328041 acccgatcca cctcgacgcg tgccgggttg acttcggcaa gtcccgcgac cggccccgcg
1328101 atggctgccc gtagtgctac tcccagctcg gcgcgcagtg cgctgattgt gccgcggacc
1328161 cacgaggtga cagctcggcc ggtcgtggtt tggggcagca gcacatagat ccgtgagccg
1328221 ttggcggcaa cctgagcgtc gtggcgaaaa gcgctggcgc tcaatgccat gacgtcaaca
1328281 agccgaacat ggcggactgc ggtatcgcgg ttttccgcgg tgtcgaaacc gatcagcgtt
1328341 gcgttgccct cggcggcgac gccgagttca cgggcgatgg tcgatacgtc gacgggtgct
1328401 gtggttgcgt tcagctcggc caggcccagt agttgctgta cccgcagcgc gtgcgtattg
1328461 ggctgggtcg ccagtcgcga catgatccgg gcggccagca ccgcagcacc ccgcaacatc
1328521 tcctcggcat cgtcggccaa cggctgcgag ccttgctgga cccagatcgt gccggcgaac
1328581 accggtggcc gcagcgcacc gacccccggc tgatgaatcc cgatggctag ccgaggacgc
1328641 aaccccagct cggggcgctc ggccacccgc accacctcac ggccgggccg cagggcatcg
1328701 aagatgcccc attgacctat ccactgcaga tgctcgggcg ggccggcgcg gcccaggatg
1328761 gacagccgac gcagctcgtc ggcctcgtcg ttggaggccg agtaggcgag cacgtgcgac
1328821 tgggcgtcct cgatgctgat catgccgtgg atgcggtcgg ccagggactg tgccaacccg
1328881 aacaggtcgg ttccggaatc gtcggtgggg tcggcccggt caccatgatg ctccaagaca
1328941 tgattcacca agtggtacag ccgttcccag cgggcccgcg gctccacggc taccaccgcc
1329001 gagccggcgc ggacggcccc ggccaccacc gagtccgacg ggtgcttgac gaagatcgcc
1329061 accggcgccc gttggcgtgc ctgatcgtcg acccagcgca ccgcctcgtc gtcggtgacc
1329121 ccgatcagga agaacacatc ggccgagccc gccgcggccg ccaggcccag ccgcacgtcg
1329181 tcggaatcga tcagcgccgt cgacgccacc ggcaggtcca ggccgcgcgg ggcgtccacc
1329241 aggctgacca cggtcgcatc cagcgccagg agcaactggc cgagccccac gccggcgatc
1329301 cgcatgttgt ccgatcctac tagcaagtcc gccagatctt gtctgatcgg ccaaacattt
1329361 gcgatgcctg ggcggggatg ctggcaggca tggacgcgat cacccaggtg ccggttccgg
1329421 ccaacgagcc ggtgcacgac tatgcgccga aatccccgga acggacccgg ctgcgcaccg
1329481 aactggcctc cctggccgat caccccatcg acctgccgca cgtcatcggc ggccgacacc
1329541 ggatgggcga cggcgagcga atcgacgtcg tgcagccgca ccggcacgcc gccaggctgg
1329601 gcaccctgac caacgccacc cacgccgacg ccgcggccgc cgtcgaagcc gccatgtctg
1329661 ccaaaagtga ctgggcggca ctgccgttcg atgaacgtgc cgcggtgttc ctgcgcgccg
1329721 ccgatctgtt ggccgggccg tggcgggaaa agatcgccgc cgcaaccatg ctcggccaat
1329781 ccaagtcggt gtaccaggcc gagatcgacg cggtctgcga gctgatcgac ttctggcggt
1329841 tcaacgtcgc tttcgcccga cagattttgg agcagcagcc gatcagtggc ccgggggaat
1329901 ggaaccggat cgactaccgc ccgctggacg gtttcgtcta cgcgatcacg ccgttcaact
1329961 tcacctcgat cgccggcaat ctgccgaccg ccccggctct gatgggcaac accgtgatct
1330021 ggaagccgtc gatcacccag acgctggcgg cctatctgac catgcaactg ctcgaggccg
1330081 ccgggttgcc gcccggggtg atcaacctgg tcactggcga cggattcgcg gtttccgatg
1330141 tggcactggc cgatccacgg ctggccggca tccacttcac cgggtcgacg gctaccttcg
1330201 gccacctatg gcagtgggtg ggtaccaata tcggccgcta ccatagctat ccgcgactgg
1330261 tcggcgagac cgggggcaag gacttcgtgg tggcgcacgc ctcggcccgc ccggatgtgc
1330321 tgcgcacggc cctgattcgc ggagcattcg attaccaggg ccagaagtgc tcggcggtgt
1330381 cgcgagcgtt tatcgcgcat tcggtgtggc agcggatggg cgatgagttg ctggccaaag
1330441 ccgccgagct gcgctacggt gacatcaccg acctgtccaa ctacggtggt gcgctgatcg
1330501 accagcgcgc cttcgtcaag aacgtcgacg ccatcgaacg ggccaaaggc gcggccgcgg
1330561 tcaccgtcgc cgtcggcggc gaatacgacg acagcgaagg ctatttcgtg cgccccacgg
1330621 tgttgctctc cgacgacccg accgacgagt cgtttgtcat cgagtacttc ggtccgctgc
1330681 tgtcggtgca tgtctacccc gacgagcgct acgagcagat cctcgacgtc atcgacaccg
1330741 gatcccgcta cgcgctgacc ggcgcggtca tcgccgacga ccggcaggcc gtgctgaccg
1330801 cgctggatcg gctgcggttc gcggcgggga acttctatgt caacgacaag ccgacggggg
1330861 cggtggtggg gcgtcagccg ttcggcggtg cacgcggatc gggcaccaac gacaaggccg
1330921 gttcgccgtt gaacctgctg cggtggacgt cggcgcgcag catcaaggag acgttcgtcg
1330981 cggccaccga ccacatctac ccgcacatgg cggtcgactg atggccggct ggttcgcgca
1331041 cacgctgcgc ccggcaatgc ttgccgccgg ccgctcggat cggctgggcc gcatcgtcga
1331101 gcgctcgccg ctcacccgcg gggtggtgcg ccggttcgtg cccggcgaca cgctcgacga
1331161 cgtggtggat atcgttaccg cgctgcggga ttcgggccgc tacctcagca tcgactacct
1331221 gggcgagaac gtcaccgatg ccgacgacgc tgccgccgcc gtgcgggcgt acctggggct
1331281 cttggacgtg ctgggccgcc gcggcgatat cgcatgcgac ggggtgcgac cgctcgaggt
1331341 gtcgctcaag ctgtcggcgc tcgggcaggc cctcgatcgc gacggccaga agatcgcgct
1331401 ggacaacgcc cgcgccatct gtgagcgggc cgagcgggtg ggcgcctggg tcacggtgga
1331461 cgccgaagac cacaccacca ccgattccac attgtcgata tcgggcgatt tgcgcgtcga
1331521 ctttccttgg ctgggcacgg ttgtgcaggc ctatctgcgg cgcacgctgg ccgattgcgc
1331581 ggagttggcg gccgtgggcg cccgagtccg gttgtgcaag ggcgcctatg acgaacccgc
1331641 atcggtggcc taccgagacg ccgcgcaggt caccgactcc tatctgcggt gccttcgggt
1331701 attgacggcg gggcgaggct atccgatggt ggccacccac gacccggtga tcatcgcggc
1331761 ggtaccgggg atcacgcgcg aatcagggcg tagtcaaggt gatttcgaat accagatgct
1331821 ctacggcgtc cgcgacgacg aacaacgacg actgaccggc gccggtaacc acgtgcgggt
1331881 gtatgtgccc ttcggcaccc ggtggtacgg gtatttcctg cggcggctgg ccgaacgccc
1331941 ggccaacctg gcgttcttcc tgcgggcgct gaccgaccgc cgacgcgcgc gggggtgcgc
1332001 cgagcgctga aatcgccggt tgctgtcaca ttcggcgggg ctgtctcgtc cttgatgtta
1332061 tgaattccag catgggtcgg cgggaggaca catgtcgcaa cacgacccgg taagtgcggc
1332121 ctggcgggcg catcgggcct acctggtgga cctcgcgttt cgtatggtag gtgacatcgg
1332181 cgtggccgaa gacatggtgc aagaggcatt ttcccgcttg ctgcgggctc cggtcggcga
1332241 catcgacgac gagcgtggct ggctgatcgt ggtcaccagc cggctgtgcc tggatcacat
1332301 caagtcggcg tcgacacgcc gggagcgccc gcaggacatc gccgcatggc acgacggtga
1332361 cgccagcgtg tcatcggttg acccggctga ccgggtgact ctcgacgacg aggtccggct
1332421 ggctttgctg atcatgctcg agcgcctcgg ccccgcggag cgggtggtgt tcgtgctgca
1332481 cgagatcttt gggctgccct accagcaaat cgccacgacg attggcagcc aggcctccac
1332541 atgccggcag ctggctcatc gggcccgtcg caagatcaac gaatcgcgca ttgcggccag
1332601 cgtggagcca gcccagcatc gcgtcgtcac cagagctttc atcgaagcct gctccaacgg
1332661 agacctggac accctgctcg aggtgctgga tccgggtgtc gccggcgaga tcgacgcccg
1332721 caaaggcgtt gtcgtcgtgg gcgcggatcg ggttggcccg accatcctgc gccactggag
1332781 tcaccccgcc accgtcctgg tagcccagcc ggtgtgcggt caaccggcgg tgctggcctt
1332841 tgtcaaccga gcgcttgccg gcgtgttggc cctgtcgatc gaggccggca agatcacaaa
1332901 aatccatgtc ttagtgcagc cttcaacatt ggacccgtta cgggccgaac tcggcggcgg
1332961 ttagttaggt atcggaggta tgaccatgaa atcacttgcc gcgcttgacc ggccgagctg
1333021 gttgtcatcg tcggcgtggc cctggcagcc ctacctgctg agccaccatc agggcggcat
1333081 cgcggttacc gatatcggcg acgggccggc ggtgctgttc gttcacgtcg gcagctggag
1333141 ctttgtctgg cgtgacgtgt tgttgcgtct agccaacgat tttcggtgtg ttgccatcga
1333201 cgcaccgggt tgtgggctca gcgaccggct ctcaaccccg ccaacacttg cccaggcggc
1333261 cgatgcaatc acctcggtca ttgatgcgct gcagttacgt gacctcaccc tggtagccca
1333321 cgacctgggc ggcccggccg gcttcctggc cgccgcccgt cgcggcgacc gcgtcgcggc
1333381 actggccgcg gtcaactgct tcgcatggcg gcccacgggt ccgctgttcc ggggcatgct
1333441 cgcggcgatg ggcagcgccc ccgtgcgtga actggacgcg gccatcaatg cgcttgcccg
1333501 cgcgacgtcg acgcggttcg gggccggtcg gcactggagc cgcgcagacc gcgcggcttt
1333561 tcgggcggga atcgatgcgc cggcccgcag ggcgtggcat gcctacttcc gcgatgcgcg
1333621 ccgtgcccat gccctctata ccgacgtcga cgccgcgttg cgggggggtc tggccgatcg
1333681 gccactgctg accatcttcg gtcagttcaa cgatccgctg cggtttcagc cgcgctggaa
1333741 agagttgttt ccgacggcac gccaactgca ggtccgccgg ggcaaccact ttcccatgtg
1333801 tgacgaccca gacctggtgg ccggggcact cacgtctttc gtgcaacggt caacgtgagc
1333861 cgccgactgc cgtcacacct ggtacacctt gcggtttgcc gccgcgccgc cacatgccaa
1333921 gctactcgcc atggccgtcg ctattgcccg tccgaaattg gaaggaaaca tcgccgtcgg
1333981 cgaggaccgc cggatcggct tcgccgagtt cggcgccccg cagggtcgtg cggtcttctg
1334041 gctgcatggc accccagggg cccggcggca gatcccgacc gaagcccggg tctacgccga
1334101 gcaccacaat attcgtctga ttggcgtcga tcggcccggc atcggcgcct cgacgccgca
1334161 tcagtacgaa accatcttgg cgttcgccga cgatctgcgg accatcgccg acacgctcgg
1334221 catcgacaag atggccgtgg tgggcctgtc gggcgggggc ccatacaccc tggcgtgcgc
1334281 cgccgggctg cccgaccggg tggtcgccgc cggtgtcctc ggcggcgtcg cgccgacgcg
1334341 cggcccggac gcgattagcg gcggtttgat gcgccttggt tcggcggtgg cgccgctgct
1334401 gcaggtgggc ggcaccccgc tgcggctggg tgcgagcttg ctgatccggg cggcccggcc
1334461 cgtcgcgtcc cctgccctcg acctgtatgg cctgctctca ccgcgggccg accggcattt
1334521 gctggctcgg cccgagttca aggcgatgtt cctcgacgat ctgctcaacg gtagtcgcaa
1334581 gcagctcgct gcgccgttcg ccgatgtcat cgcctttgcc cgcgactggg gattccggct
1334641 ggacgaggtg aaagtccccg tccgctggtg gcacggagac cacgaccaca tcgtcccgtt
1334701 ctcccacggg gaacacgtcg tatcccggct tcccgacgcg aagttgttgc acttgcccgg
1334761 cgaaagtcat ctcgctgggc ttggccgtgg tgaagagatt ttgagcaccc tgatgcagat
1334821 ttgggaccgc gacctgcgga aatgatcggg cgtgtgaccg agctcgcatg ggcgggccgc
1334881 actgctttgc atcgccattt gtgcctattg acggccttaa tatgacatgc tgttgcctgt
1334941 gttagagccc gctgaccgcc cctgtgatgc ccccggatgg tttctctacc tcaccgacat
1335001 accgcgcgcg ggtgtcgagt acgggcaatt gctcgccgtg ctgccgctgc agcggatgct
1335061 gccggccggc gacggacatc cggtactggt gctacctggc ctgctggccg gcgacggttc
1335121 cacctggatc ctgcgacgga tcttgcgtcg cctcgggtac gcggcctacg gctgggggct
1335181 cggccgcaac atcgggccga cggccaaagc ggtatccggg atgcgggacc tcctcgacaa
1335241 gctccactcc cggtaccaca ccccggtgag cctgattggg tggagcctgg gtggcatctt
1335301 cgcgcgcggc ctcgcccgcg accatccgtc ggcggtgcgc caggtgatca cactgggcag
1335361 cccgtttggc atgagggaca cctgtgagac gcgctccgcg tggagcttca accggtatgc
1335421 gcatctgcac accgagcggc acgagttgcc gctggaaatg gaaagtgaac ctttgccggt
1335481 gccgaccacc gcgatctact cgcgctgcga cggcatggtc gcctggcaga cgtgcatgaa
1335541 ttcgccatcg gagcgcgcgg aaaacatcgc ggtgcgcagc agccacatcg gctacggcca
1335601 caatccgccg gtggtgtggg ccatcgccga ccggctggca cagccccagg gtgcatgggc
1335661 gccgtttcgg ccgccgaagg tgttgagccc gctgtttccg cgaccggata caccggcaga
1335721 ggcggtcagc accccccaga cgcgaccggc ctgacggggc aggcgatcac ggcgccgggg
1335781 tagcctcgct cacgtgctgc tggcctccct gaatcctgct gtcgtctccg ccgccgatat
1335841 cgcggacgcg gtccgcatcg acggcgacgt gctgagccgt agcgacctgg tcggcgcggc
1335901 aacgtcggtg gccgagcggg tcgccggtgc gcaccgggtc gccgtgctgg ccacgccgac
1335961 cgcgtcgacg gtgctggcga tcaccggctg cctgatcgcc ggcgtgccgg ttgtgccggt
1336021 acccgccgat gtgggcgtca ccgaacgccg gcacatgctc accgactccg gcgtccaggc
1336081 atggctgggc ccgttgcccg acgacccagc ggggctgcca cacatcccgg tgcgcacgca
1336141 cgcgcggtcc tggcaccgtt atccggagcc ctcacccggg gccatcgcca tggtggtcta
1336201 cacgtccggc accaccgggc cgcccaaagg cgtgcagctg agccggcggg cgatcgccgc
1336261 cgacctcgat gcattggcag aggcctggca gtggacggcc gaggacgtgc tggtccacgg
1336321 tctgccgctg tatcacgttc acggcctggt gctgggcttg ctcgggtcgc tgcggttcgg
1336381 aaatcgcttc gtgcacaccg gtaaaccaac gccggccggc tacgcccagg cctgttatga
1336441 agcgcacggc acgttgtttt ttggggtgcc gacggtgtgg tcacgagtgg cggccgacca
1336501 agctgccgcc ggggcgctca aaccggcgcg gctgctggtg tccgggagtg cggcactacc
1336561 cgtgccggtg ttcgacaagc tggtgcagct caccgggcac cggcccgtcg aacgctacgg
1336621 tgcttcggag tcgctgatca ccctatcgac gcgggctgac ggtgagcgtc gcccgggctg
1336681 ggtcggcctg ccgctggccg gtgtgcagac ccgactggtg gacgacgatg gcggtgaggt
1336741 cccgcacgac ggggaaaccg ttggaaagct tcaggttcgc ggtccgaccc tgttcgacgg
1336801 ctacctgaat caacccgatg ccaccgccgc ggcgttcgac gccgacagct ggtaccgcac
1336861 cggcgacgtc gcggtggtcg acggcagtgg gatgcaccgc atcgtgggac gcgagtcggt
1336921 cgacttgatc aagtcgggtg gataccgggt cggcgccggt gaaattgaaa cggtgctgct
1336981 cgggcatccg gacgtggcgg aggcggcagt cgtcggggtg cccgacgatg atctaggcca
1337041 gcggatcgtt gcctacgtag tcggctcagc gaatgtcgat gcggacgggc ttatcaactt
1337101 tgttgcccaa caactttcgg tgcacaagcg cccgcgcgag gtgcgtatcg tagatgcgct
1337161 gccgcgcaac gcgttgggga aagtgctcaa gaagcagttg ctgtcagaag gctgagctac
1337221 ggcgaattat cgtgtaccgc tggacagtta cgctggcaca ctgttactcc gacggcccgg
1337281 tgagcttagc gcatgggcct tgttgccgcg ccactgtagg gcttccaggg cgacggccac
1337341 atggacggag gtgtggtcga gcggtcgcgg tagcagccgc tgagcggact cgagtctgcg
1337401 cagaaatgta ttgcggtgag tgtggagacg ttttgcggcc cgggaggcgt tgcactgctc
1337461 gttgatgaag gtcagcaggg ccgtttgtag atctgggctg gcagactcga ggtctccaag
1337521 cgtactcgtg atgaattcgc ttgcagcatc tggattttgg ctgatcaatg cgaccatctt
1337581 aacgtcggca aagaaggcga cccgctgggt cgaccgtagc cgtgacaagg tgcgctgggt
1337641 gatgagcgct tcgaggtggc tgcgccggaa cccctccacc ccgttggcgg tggtcccgat
1337701 ggcgatgcgc gccccgggtg cgttgtccac cgccgcctgc actgtgtcga tgtcgagtcc
1337761 gtcggcgtcg gtcacccacg cccagcggct cgccgccccg gcgaccaccg tcagcggtcg
1337821 tgtcgatccc acggcgtggc agaacagatc agccgcccgg tcgaggtagc tgtggtcacc
1337881 gtcgagctcg tcgctccaga tgatggcagc ggtatgggca cgactcagcg ggtagcccaa
1337941 tttcgcttcg gcccgttcgg ggctgatagg ggcgccatcg agaatcagcc cgacgacctc
1338001 gaggcgttcg gcatgggtgc tgcgggtcag ttcgtcgtgt tccgactgca cttgcgcggc
1338061 gataccggtc agcgtggcct cgatgaagtc gttgacggag cgggccgaca cgtctagcag
1338121 ctcgcgcagc tcttgggggt cggaagtgag ttcgaacgca atccccatcc agaaccgcca
1338181 cccgatgtgc tcaccggttc gatagatgtt gaacgctact gtgtccagcc cccggcgcac
1338241 caggtctcgg gccatccgca gtggctcggt gccgagattg gcgggcaccc gagcaccagg
1338301 gtcacgcagg ttggccgcag cccagtacac caggttggcg cgattggccg tctggacaac
1338361 cttcgcaagc accggatcgt tggcgatcgc cggattggcc gcaatcgtgg cacggtccag
1338421 ttcctcgatc cactccgggc tgggattgag ggcgatgcgt gctccctcgc ggatcagctc
1338481 acgaattcgc ggcgaaggtt gttgccatgc cacgcgccga tcttagggcc agcgggtgca
1338541 atttgcacac tatgttggca ctattgtgcc ggattcacac tgcacggccg gtgtgtgcgc
1338601 gaaatcacgg tgtgggtctg ctggatgagt cgaccgtgtt gaacaacttg cgacacaccg
1338661 caatttgcga aatccgccac cgaccgggca tagtaaccca gctagtcgtc gttgtcgcgt
1338721 cgaaccacat ggtgaactgt gcggcgggtg cattttgcac atcaagtggg cgctgattgg
1338781 gaagatttac ccttcggcgg cggcggtagg tgcagattgc actttggctc atgctgattg
1338841 aaattttttg acctgttgcg gtccttgcgg gctcgccatc attggcggca gttcgtcacc
1338901 gacgaatcgg ggccaaggac gtaggcgacc agttcgcttg actgctaacc gctcctgatc
1338961 gtacccgtgc gagtgctcgg gccgtttgag gatggagtgc acgtgtcttt cgtgatggca
1339021 tacccagaga tgttggcggc ggcggctgac accctgcaga gcatcggtgc taccactgtg
1339081 gctagcaatg ccgctgcggc ggccccgacg actggggtgg tgccccccgc tgccgatgag
1339141 gtgtcggcgc tgactgcggc gcacttcgcc gcacatgcgg cgatgtatca gtccgtgagc
1339201 gctcgggctg ctgcgattca tgaccagttc gtggccaccc ttgccagcag cgccagctcg
1339261 tatgcggcca ctgaagtcgc caatgcggcg gcggccagct aagccaggaa cagtcggcac
1339321 gagaaaccac gagaaatagg gacacgtaat ggtggatttc ggggcgttac caccggagat
1339381 caactccgcg aggatgtacg ccggcccggg ttcggcctcg ctggtggccg cggctcagat
1339441 gtgggacagc gtggcgagtg acctgttttc ggccgcgtcg gcgtttcagt cggtggtctg
1339501 gggtctgacg gtggggtcgt ggataggttc gtcggcgggt ctgatggtgg cggcggcctc
1339561 gccgtatgtg gcgtggatga gcgtcaccgc ggggcaggcc gagctgaccg ccgcccaggt
1339621 ccgggttgct gcggcggcct acgagacggc gtatgggctg acggtgcccc cgccggtgat
1339681 cgccgagaac cgtgctgaac tgatgattct gatagcgacc aacctcttgg ggcaaaacac
1339741 cccggcgatc gcggtcaacg aggccgaata cggcgagatg tgggcccaag acgccgccgc
1339801 gatgtttggc tacgccgcgg cgacggcgac ggcgacggcg acgttgctgc cgttcgagga
1339861 ggcgccggag atgaccagcg cgggtgggct cctcgagcag gccgccgcgg tcgaggaggc
1339921 ctccgacacc gccgcggcga accagttgat gaacaatgtg ccccaggcgc tgcaacagct
1339981 ggcccagccc acgcagggca ccacgccttc ttccaagctg ggtggcctgt ggaagacggt
1340041 ctcgccgcat cggtcgccga tcagcaacat ggtgtcgatg gccaacaacc acatgtcgat
1340101 gaccaactcg ggtgtgtcga tgaccaacac cttgagctcg atgttgaagg gctttgctcc
1340161 ggcggcggcc gcccaggccg tgcaaaccgc ggcgcaaaac ggggtccggg cgatgagctc
1340221 gctgggcagc tcgctgggtt cttcgggtct gggcggtggg gtggccgcca acttgggtcg
1340281 ggcggcctcg gtcggttcgt tgtcggtgcc gcaggcctgg gccgcggcca accaggcagt
1340341 caccccggcg gcgcgggcgc tgccgctgac cagcctgacc agcgccgcgg aaagagggcc
1340401 cgggcagatg ctgggcgggc tgccggtggg gcagatgggc gccagggccg gtggtgggct
1340461 cagtggtgtg ctgcgtgttc cgccgcgacc ctatgtgatg ccgcattctc cggcggccgg
1340521 ctaggagagg gggcgcagac tgtcgttatt tgaccagtga tcggcggtct cggtgtttcc
1340581 gcggccggct atgacaacag tcaatgtgca tgacaagtta caggtattag gtccaggttc
1340641 aacaaggaga caggcaacat ggcctcacgt tttatgacgg atccgcacgc gatgcgggac
1340701 atggcgggcc gttttgaggt gcacgcccag acggtggagg acgaggctcg ccggatgtgg
1340761 gcgtccgcgc aaaacatttc cggtgcgggc tggagtggca tggccgaggc gacctcgcta
1340821 gacaccatgg cccagatgaa tcaggcgttt cgcaacatcg tgaacatgct gcacggggtg
1340881 cgtgacgggc tggttcgcga cgccaacaac tacgagcagc aagagcaggc ctcccagcag
1340941 atcctcagca gctaacgtca gccgctgcag cacaatactt ttacaagcga aggagaacag
1341001 gttcgatgac catcaactat caattcgggg atgtcgacgc tcacggcgcc atgatccgcg
1341061 ctcaggccgg gttgctggag gccgagcatc aggccatcat tcgtgatgtg ttgaccgcga
1341121 gtgacttttg gggcggcgcc ggttcggcgg cctgccaggg gttcattacc cagttgggcc
1341181 gtaacttcca ggtgatctac gagcaggcca acgcccacgg gcagaaggtg caggctgccg
1341241 gcaacaacat ggcgcaaacc gacagcgccg tcggctccag ctgggcctga caccaggcca
1341301 aggccaggga cgtggtgtac gagtgaaggt tcctcgcgtg atccttcggg tggcagtcta
1341361 ggtggtcagt gctggggtgt tggtggtttg ctgcttggcg ggttcttcgg tgctggtcag
1341421 tgctgctcgg gctcgggtga ggacctcgag gcccaggtag cgccgtcctt cgatccattc
1341481 gtcgtgttgt tcggcgagga cggctccgac gaggcggatg atcgaggcgc ggtcggggaa
1341541 gatgcccacg acgtcggttc ggcgtcgtac ctctcggttg aggcgttcct gggggttgtt
1341601 ggaccagatt tggcgccaga tctgcttggg gaaggcggtg aacgccagca ggtcggtgcg
1341661 ggcggtgtcg aggtgctcgg ccaccgcggg gagtttgtcg gtcagagcgt cgagtacccg
1341721 atcatattgg gcaacaactg attcggcgtc gggctggtcg tagatggagt gcagcagggt
1341781 gcgcacccac ggccaggagg gcttcggggt ggctgccatc agattggctg cgtagtgggt
1341841 tctgcagcgc tgccaggccg ctgcgggcag ggtggcgccg atcgcggcca ccaggccggc
1341901 gtgggcgtcg ctggtgacca gcgcgacccc ggacaggccg cgggcgacca ggtcgcggaa
1341961 gaacgccagc cagccggccc cgtcctcggc ggaggtgacc tggatgccca ggatctctcg
1342021 gtagccctcg gcgttgacgc cggtggcgat caaggtgtgc actccgacga cgcggcctgc
1342081 ctcgcgcacc ttgagcacca gggcgtcggc ggcgaggaag gtatacgggc cggcatcgag
1342141 cgggcgggtc cgaaacgcct ctacggcttc gtcgagctct ttggccatga tcgacacttg
1342201 cgacttggaa agctttgtca caccaagtgt ttcgaccagg cgctccatcc ggcgagtgga
1342261 tactcccagc aggtagcagg tcgccaccac gctggtcagt gcgcgttcag ctcgcttgcg
1342321 gcgctgcagc agccagtccg ggaaatagct gccctggcgc agcttgggga tcgcgacgtc
1342381 gatggttgcg gcacgggtgt cgaaatcacg gtggcggtag ccgttgcgct gattggaccg
1342441 ctcatcgctg cgttcgcggt agcccgcccc gcacagggcg tcggcttcag cccccatcaa
1342501 ggcggcgatg aacgtcgaga gcagcccgcg cagcagatcc gggctcgcct gtgcgagttg
1342561 gtcagccaga agctgctcgg tgtcgataag atgagaagag gtcattgcgt catttccttc
1342621 gattgacttt tgctggtcgt ttcgaaggat cacgcgatga ccgcccacta ctgggctacg
1342681 acacgcccac cggccttacc tgcccgtaca ccacacccct ggacgtaact tgacaccaat
1342741 ccacagcacc gagcagtgac agaaggtgcc ccaaggtgtg gtgaaactcg ctggacggtc
1342801 cccaggatgt tggcagcaca ttcaccggac atgaccggag caagaccgga catcctccca
1342861 taccgtcgtc gccgtgtaca tccgtagccc gtcctggcag gtgctgggtt gaccaaaatc
1342921 agcccaacac ctgccacgac gatgaagcgg gttgcgctgg catgtcttgt cggctcggcg
1342981 atcgaattct acgacttcct tatctacggc accgctgcgg cgctggtgtt tcccaccgtg
1343041 ttcttcccac acctggatcc cacggtggcc gccgtggcct cgatggggac atttgctgtg
1343101 gcgttcctat cccggccgtt cggcgcggcc gtctttggat actttggaga ccgcctcggc
1343161 cgcaagaaga ccctggtcgc cacactgttg atcatgggcc tggcaaccgt gactgtcggg
1343221 ctggttccaa cgacagtggc catcggcgcc gcggccccac tgatcctgac gaccatgcgg
1343281 ctgctgcaag ggttcgcggt cggcggcgag tgggccggtt cggcgctgct gagcgccgag
1343341 tacgcgcccg ccagcaaacg tggctggtac gggatgttca ccgttgtggg tggcggcatc
1343401 gcgctggtac tgaccagcct gacctttctg ggcgtgaact acaccattgg cgaaagcagc
1343461 cccacattca tgcagtgggg gtggcgcata ccgtttctgg tcagtgcggc gctgatcgcc
1343521 gtcgccctat acgtgcggtt caacatcgac gagaccccgg tgttcgcccg ggaaagggca
1343581 gacgaaaaaa cccgtttggg cccagccgaa acgccgattg cccaagtact gcggcggcag
1343641 cggcgagaga tagtcttggc cgccggcagc gccgtttgct gcttcggctt cgtctacctg
1343701 gccagcactt acttggccag ctacgctcaa acccgactgg ggtattcgcg cggcagcatc
1343761 ctgttcgaca gtgtgctggg tggactgctg tgcatcgtgt tcaccgcgct ttcttccgct
1343821 ctttgcgacc aactcgggcg ccgccgcgtc ctattggccg ggtgggcggt ggctctaccc
1343881 tggtcgctgt tggtcatgcc gctgatcgac tccggcagcc ccagtttgtt cgcggtggct
1343941 gtcgtcggca tgtatgccat cggcggattc ggtttcggac ccacggcatc gttcatccca
1344001 gaactgtttg ctactagcta ccgatacacg ggcagcgcgc tcgcggcgaa tctcgctggg
1344061 gttgccggcg gcgcgctacc gccggtgatt gccggcgcgc tggtggcaac ctatggcagc
1344121 tgggcgatcg gtgtcatgct ggccatcctc gcgttgatca gcctggtatg cacctatcgg
1344181 ttgcccgaaa ccgccggatc ggccctcgtc agccgctagt tggcgtgcag gtcctcgttg
1344241 agggcaatgc cctgaccgtc gcgggccagc acttcgaccg ccccgctgac ggaattgcgg
1344301 cgaaacagca ggttgctgct cccggagagc tcacgcgcct tgaccgaatt gctgtcgggc
1344361 atggtgaccc tcgtgccggc ggtcacgtac agcccggcct ccaccacgca gtcgtcgccc
1344421 agtgagatgc ccagaccgga gttggcgccg agcagacaac gcttgccgat cgaaatgacg
1344481 tgtgttccac cgccagacag cgtgcccatg atcgacgctc cgccgccgac atcggagccg
1344541 tcgcccacca ccacacccgc cgagatgcgg ccttccacca tcgaggcgcc cagggtgccg
1344601 gcgttgtagt tgacgaagcc ctcatgcatc acggtggtgc ccggcgccag gtgagcgccc
1344661 aaccgcacgc ggtcggcatc ggcgatacgt acgccggtgg gcacgacgta gtcgaccatc
1344721 cggggaaact tgtcgacgcc atacacagtc accggtccgc ggcggcgcag ccgcgcccgc
1344781 accgcctcga aaccgtctat ggcgcagggt ccgtgattgg tccacaccac attggtcagc
1344841 accccaaaca agccgccggc gttcaaccca tggggcgcca ccaggcggtg cgacaagagg
1344901 tgaagccgca ggtaagcatc gtatgggtca gcggcgacat cgtcgagcga gccgatgacc
1344961 gtacggaccg cgatggtctc ggtgcggcgg tcgtcatcgc ggccgatcag cgcggccagc
1345021 tcgacaggaa cgtcggacac cgccagtcgt gacgtcgcgc tggtgcccga ttcggtcagt
1345081 tccggcgcgg gaaaccaggt gtcgaggacc gatccgtcag cggcgagggt agccaggccg
1345141 atgcctgctg ctccagtcac ggtcgacacg ctacttgtgc cgccgaacag acacaaaacc
1345201 accctatttc gaccagaatc gggtgctttt gcgtctgctc ggccaactaa gctagcgccg
1345261 tgctggattt gcgcggggac ccgatcgaat tgaccgcggc gctgattgac atccccagcg
1345321 agtcgaggaa ggaggcacgc atcgccgacg aggtggaagc ggcgttgcgc gctcaggcat
1345381 cggggttcga gatcatccgc aacggcaacg cggtgctggc gcgtacaaag ctgaaccggt
1345441 cctcgcgggt gctgttggcc ggacacctgg acaccgtgcc agtggccggc aacctgccta
1345501 gccgccgcga gaacgaccag ctgcacggct gcggcgcagc cgacatgaaa tccggcgacg
1345561 cggtcttcct tcatctggcc gctacactgg ccgaaccgac gcacgatcta acactggtgt
1345621 tctacgactg cgaggaaatc gattcggcgg caaacggttt aggccgcatc cagcgcgagc
1345681 tgccggactg gctatccgcg gatgtagcca tcttgggtga gcccaccgcc ggctgcatcg
1345741 aggctggttg ccagggcacg ttgcgtgtcg tcctcagcgt gaccggaact cgcgcgcatt
1345801 cagcgcgttc gtggttgggt gacaacgcaa tccacaagtt gggtgctgtg ctggaccggt
1345861 tggccgtcta ccgggcacgc agcgtcgaca tcgacggttg cacctatcgg gagggcctct
1345921 cggcggtgcg cgtagcaggc ggcgtcgccg gcaacgtgat ccctgacgcg gcctcggtca
1345981 cgatcaacta ccgctttgcc cccgaccggt cggtggccgc ggcattgcaa catgtccatg
1346041 acgtgttcga cgggctcgac gtgcagatcg agcagacgga cgccgcggcc ggtgcgctgc
1346101 ctggcctgtc cgagcccgcg gccaaggcgc tggtcgaggc cgccggcggg caggtccggg
1346161 ccaagtatgg ctggactgat gtgtcgcgct ttgccgcttt gggcataccg gcggtcaatt
1346221 acggcccggg tgatcccaac ctggcgcact gccgcgacga acgggtgccc gtcggcaaca
1346281 tcaccgcggc cgtggacttg ctgcgccgat acctgggtgg ctagcgctgc tgtggcccca
1346341 agcgtgctgc cgccttggtc gcgtcggctg ccgcggctgc catcccgatc ccggccagct
1346401 cctcagccac cgcggtcagc tcggcagcat ctccgtcggc caggccacgg gcgtgcttga
1346461 cgaggatatt tcctacggtg cagtcgattt cggcggcgag gcgagtcacc gggtccaccg
1346521 cacggatgtc gcccaaccga accgcgttat gccaggcgca tagggccacc gccgcctgcc
1346581 cggcccgctc agccgtccgg gcggcctccc gggccgccgc gatggcccct gtcatgtcct
1346641 gggccgccgc cctggtccag gccctggcca gcccgagctc gggtgcgaac aacgcggact
1346701 tcgttccgtg ccgagcttca gcgcgctgca gtgtttttgc agactcggcg atatggcctt
1346761 gctgcgcgat ggccgttgcc aacaacatca gcgacagcgg accccacgag tagccggttc
1346821 gttccagtgt ggcggcggcc ggctccagca tcgatgccgc ggcgccgaat tcgcctttgg
1346881 tgatcagtac gtacgccaac aacacttcac cgatggaccg gccaggttgc tgcagctagg
1346941 cgaagtcggt gaaccgcttg gccagctcct gagccggcgc gacgtcgcct gccagcagca
1347001 gcgacgtgat ctgagccagg cccacggtga accgcagcag ccccggatgt tcggcggccg
1347061 acgcccgttc ggccagccgg tcaacgtcgc cgaaccggcc cattcgtgcc gatgataacg
1347121 cggcagcgct ggcggcccag gccacggcca tgtcgtcggc agccggtccg gacagcacct
1347181 cggtggccag cgtgatggcc cgcggcaagt ttccggagtt catcgcaaac gtggccgcca
1347241 gcgcatccag ggtgctgcgg gccgtgggct cggtcactcg gctgcgggtc gtctgcagaa
1347301 acgccgtggc gcgctcgggc tcgttgagca tccagaaccg attcgccgcc cggggtatcg
1347361 cccaggccat cagctcggtc tcggtcaatt cggcgggatt caccgccgcc agcaccgcgt
1347421 cagcttcgcg accgcgaccc tgccaaccga gtgcgtaagc caagggcagg cgtgccgcca
1347481 gggcgtccga cctatccagc gctgcccgcg ccaaccgttc ggcaagccgg acgtcgccga
1347541 gccgcagggc ctgcccggct gcggtcgccg catccgtgac cgcggccggg gtagcactgg
1347601 cggggacgtc gatggccagt gaggacagcc gtaactgatc gctgacatgg tcggatgggt
1347661 gcttggccag ctgcgcgacc agcgacacgc gcaatgcatg cgcgtgctcg gccgtcaata
1347721 cggcgcgtgc gcggtcggcg tacagcggat ggccgacaaa aatctcgctg gtatcgctgt
1347781 cgggacccac ccgcaccgcg ccggcggctt cggcttggcc gagcgtgtcc aactgctcgc
1347841 caccgaccag ggccaccagg tcggtgcgcg ccaacggttc ggcgatggcg aggtagtcga
1347901 caacggcgcg ggccggttcc ggcagggcgc acaggtactc gtcgatcacg ccggacagcg
1347961 gccgacgatc ctcgtctcga cagcgccacc ggccgtccac gtgttcgaga ccaccgccgt
1348021 cgatgaggtg gcgcagatac aacgggttgc caaggctgcg ccgaaagagc tcgtcggcgt
1348081 cggcgacgtc cagtgtcgcg tccagcgccg actccacgaa cgccgcggtt tgggccctgt
1348141 cgagcggctc gatggcgacc cgggtgagca ggtcatcgga ccagagcgca gctatagcgt
1348201 ccggtggctc ggcctccgag gcgacggtga ccaccagccg cgccgccccg gcccgcgcca
1348261 gctggtacac caaggtggcc gacagcggat ccaggttgtg cgcgtcgtcg accaccagca
1348321 gcagatcgcc agcatcaccg gtcagggaac tacgcgccgc ccgcagcagc gccgcgggcc
1348381 gcccaatgtc ggctccggag gcgggcaggc tgatcaaatg gcggaaagcg ccgaacggga
1348441 tggcccgccc tggagcggtt cccaccaccc agcgagcccg gccgctcctg ccgtcctcgg
1348501 acatgacctg ctcggcagcc agttgcgcca gcagcgtctt gccgacgccg tgtggcccga
1348561 ccagcaccac cccgcaccga tccggactgt cgacggccgc ctccacgtgt ttccagacgc
1348621 gcatcgccgg attttatggc ggttgcgccc aacgacattc gagcggggga taggccaaaa
1348681 atgtacgcgg ttcacatcgg tggtctacgt tctggtgtat gtcggcgaaa atcgacatta
1348741 ccggtgattg gactgtggcc gtgtattgcg cggcctcgcc aacgcacgcg gagttgctag
1348801 agctggccgc cgaagtcggc gcggcaatcg ccggacgtgg ctggacgctg gtgtggggag
1348861 gtggccatgt ttcggcgatg ggggctgtcg cctcggcggc gcgagcctgc ggcggctgga
1348921 ccgtcggcgt gattcccaag atgctggtgt accgcgaact ggctgatcac gacgccgacg
1348981 agctaatcgt caccgacacc atgtgggagc gcaagcagat tatggaagat cgctcagatg
1349041 cgttcatcgt gttgccgggc ggtgtcggca ccctagacga gctgtttgac gcatggaccg
1349101 acgggtatct cggtacccat gacaaaccca ttgtgatggt agatccctgg gggcatttcg
1349161 atggactgcg ggcatggctg aacggattgc tcgacaccgg ttacgtctca cccacggcga
1349221 tggaacggct ggtggtagtc gataacgtca aggacgctct gcgggcctgc gcaccttcct
1349281 gaggttggtc gacaaccaat tcgacatttc gcaaacgaat cgagggctta cgtgtccgat
1349341 tactacggcg gcgcacacac aacggtcagg ctgatcgacc tggcaactcg gatgccgcga
1349401 gtgttggcgg acacgccggt gattgtgcgt ggggcaatga ccgggctgct ggcccggccg
1349461 aattccaagg cgtcgatcgg cacggtgttc caggaccggg ccgctcgcta cggtgaccga
1349521 gtcttcctga aattcggcga tcagcagctg acctaccgcg acgctaacgc caccgccaac
1349581 cggtacgccg cggtgttggc cgcccgcggc gtcggccccg gcgacgtcgt tggcatcatg
1349641 ttgcgtaact cacccagcac agtcttggcg atgctggcca cggtcaagtg cggcgctatc
1349701 gccggcatgc tcaactacca ccagcgcggc gaggtgttgg cgcacagcct gggtctgctg
1349761 gacgcgaagg tactgatcgc agagtccgac ttggtcagcg ccgtcgccga atgcggcgcc
1349821 tcgcgcggcc gggtagcggg cgacgtgctg accgtcgagg acgtggagcg attcgccaca
1349881 acggcgcccg ccaccaaccc ggcgtcggcg tcggcggtgc aagccaaaga caccgcgttc
1349941 tacatcttca cctcgggcac caccggattt cccaaggcca gtgtcatgac gcatcatcgg
1350001 tggctgcggg cgctggccgt cttcggaggg atggggctgc ggctgaaggg ttccgacacg
1350061 ctctacagct gcctgccgct gtaccacaac aacgcgttaa cggtcgcggt gtcgtcggtg
1350121 atcaattctg gggcgaccct ggcgctgggt aagtcgtttt cggcgtcgcg gttctgggat
1350181 gaggtgattg ccaaccgggc gacggcgttc gtctacatcg gcgaaatctg ccgttatctg
1350241 ctcaaccagc cggccaagcc gaccgaccgt gcccaccagg tgcgggtgat ctgcggtaac
1350301 gggctgcggc cggagatctg ggatgagttc accacccgct tcggggtcgc gcgggtgtgc
1350361 gagttctacg ccgccagcga aggcaactcg gcctttatca acatcttcaa cgtgcccagg
1350421 accgccgggg tatcgccgat gccgcttgcc tttgtggaat acgacctgga caccggcgat
1350481 ccgctgcggg atgcgagcgg gcgagtgcgt cgggtacccg acggtgaacc cggcctgttg
1350541 cttagccggg tcaaccggct gcagccgttc gacggctaca ccgacccggt tgccagcgaa
1350601 aagaagttgg tgcgcaacgc ttttcgagat ggcgactgtt ggttcaacac cggtgacgtg
1350661 atgagcccgc agggcatggg ccatgccgcc ttcgtcgatc ggctgggcga caccttccgc
1350721 tggaagggcg agaatgtcgc caccactcag gtcgaagcgg cactggcctc cgaccagacc
1350781 gtcgaggagt gcacggtcta cggcgtccag attccgcgca ccggcgggcg cgccggaatg
1350841 gccgcgatca cactgcgcgc tggcgccgaa ttcgacggcc aggcgctggc ccgaacggtt
1350901 tacggtcact tgcccggcta tgcacttccg ctctttgttc gggtagtggg gtcgctggcg
1350961 cacaccacga cgttcaagag tcgcaaggtg gagttgcgca accaggccta tggcgccgac
1351021 atcgaggatc cgctgtacgt actggccggc ccggacgaag gatatgtgcc gtactacgcc
1351081 gaataccctg aggaggtttc gctcggaagg cgaccgcagg gctagcggat tccgggcgca
1351141 gtctcgatac ccgcactgga cgctcgacgg taaccaggca ctatggatgc gtgcgttcaa
1351201 caccgccggc ctcagccggt cgttcaacac cgccggcgtt agccggccat tcaacaccgc
1351261 cggcgttagc cggccattca acgctgtgcg gccgtccagt cgcaggtgat cgtgcgctga
1351321 tcatggcgat cgtcaaccgc accccggatt cgttttacga caagggtgcg actttcagcg
1351381 acgcggctgc cagagacgcg gtccaccggg ccgtcgccga cggtgccgac gtcatcgacg
1351441 tcggcggtgt caaagccggc ccgggtgaac gcgtcgacgt cgacaccgag atcacgcggc
1351501 tggtgccgtt catcgaatgg ctccgcggtg cttacccgga ccagctgatc agtgtcgaca
1351561 cctggcgcgc gcaggtggcg aaggcggcct gcgcggcggg ggcggacctg atcaacgaca
1351621 cctggggtgg cgtcgacccg gccatgcccg aggtggccgc cgagttcggc gcgggcctgg
1351681 tgtgtgcgca caccggcggc gcgctgccac gcacgcgacc cttccgggtg agctacggta
1351741 cgactacccg cggtgtggtg gatgctgtga ttagccaggt cacagccgcc gccgagcggg
1351801 ccgtcgcggc cggggtggcc cgcgagaagg tgttgatcga cccggcacac gacttcggca
1351861 agaacacctt ccatgggctg ctgctattgc gacacgtggc cgatcttgtt atgaccgggt
1351921 ggcccgtgct gatggctttg agcaacaagg acgttgtcgg ggagactctg ggcgtggatt
1351981 tgaccgaacg gcttgaggga acgctggcag ccaccgcgtt ggctgcggcc gccggggcgc
1352041 gcatgtttcg ggtgcatgag gtcgccgcca cccggcgggt gctggaaatg gtggcatcga
1352101 ttcagggggt ccggccgccg acgcgcacgg tgagaggact cgcatgacag catcggagct
1352161 ggtcgccggc gatctcgccg gtggcagggc ccctggcgcg ctgcccttgg acactacttg
1352221 gcaccgtccc ggctggacga tcggggagtt ggaagcggca aaggccggac ggacgatttc
1352281 ggtggtgctg ccggccctca acgaggaagc gaccatcgaa tcggtgatcg acagcatctc
1352341 tccgctggtc gatggcctgg tcgatgaatt gatcgtgctg gactccggtt ccaccgacga
1352401 caccgagatc cgggccatcg cctccggcgc ccgggttgtc agccgtgaac aggcgttgcc
1352461 cgaggtgccg gtacggcccg gcaaaggtga ggcattgtgg cgttcactgg cggccaccag
1352521 cggcgacatc gtggtgttca tcgactcaga cctgatcaac ccgcacccct tgtttgtgcc
1352581 atggctggtc ggtccgctgc tcaccggcga aggcattcag ctggtcaaga gcttttaccg
1352641 acggccgctg caggtcagcg acgtgacgag tggggtgtgc gccaccggcg gcgggagggt
1352701 caccgagctg gtggcgcggc cactgttagc cgcgctgcgg cccgagctgg gttgtgtact
1352761 gcagccgctg agcggtgagt atgcggccag ccgggagctg ctgacatcgc tgccatttgc
1352821 ccccggctac ggcgtggaga tcggcctctt gatagacacg ttcgaccggt tgggcctgga
1352881 cgcaatcgcc caggtcaact tgggcgttcg ggcgcaccgt aaccggcccc tagacgagct
1352941 cggcgcgatg agccgccagg tcatcgcgac cctgctgtcg cgctgtggaa ttcccgattc
1353001 cggtgtcggg ctgacccagt tcttgcccgg cggcccggac gatagtgact acacgcggca
1353061 cacctggccg gtatcactag tcgaccggcc gccgatgaag gtgatgcggc cgcgctgacc
1353121 gacaccgcgt cggcgcctta gggcaagatc gatgacgtgg cgttggtgtt ggtgtacctg
1353181 gtggtgctgg tcctggtggc gatcgtgctg ttcgctgcgg cgagcttgct attcggccgt
1353241 ggcgagcagt tgccgcccct gccgcgggcg acgacggcga cgacgctgcc ggcgttcggg
1353301 gtcacccgcg ccgacgtcga cgcggtcaag ttcacgcagg tgctgcgcgg gtacaagacc
1353361 agcgaggtgg actgggtgct ggaacggctc ggccgtgagc tcgaggcgct acgctctcag
1353421 ctcggggcga tccacgcctc gtcggaagac gccgaggccg agtctgacgc gtcaaaccct
1353481 tcgcgcggcg agaccgtcgt gcactaccgt tctgaccccg cgtgagcggc gacgggctgg
1353541 ttcgctgccc ctgggcggag gttcgtccag ggcccgatgc ccagctgtac cgcgactatc
1353601 acgacaacga atgggggcgt ccgctgtacg gccgggtggc tttgttcgag cgaatgagcc
1353661 tggaggcctt ccagagtggc ctgtcatggt tgataatcct gcgcaagcgg gagaatttcc
1353721 ggcgcgcatt ctctgggttc gacatcgaca agatcgctcg ctacaccgat accgatgtgc
1353781 gacggctact cgccgatgac ggaatcgtgc gcaaccgcgc caagattgag gcgacgatcg
1353841 ccaacgcgcg cgcagctgcc gatctggggt cgtccgaaga cctatccgag ctgctgtggt
1353901 cgttcgcgcc accgcctcgg ccccggcccg tcgacggttc cgaaattccc tcggtcagca
1353961 cggaatcgaa ggctatgtcg cgtgagttga agcggcgcgg gttccgtttc gtcgggccca
1354021 ccaccgccta tgcgttgatg caggcgaccg ggatggtcga cgaccatatc caagcatgct
1354081 gggtgcccac tgagcgacct tttgaccagc cgggctgccc gatggcggcc cggtgaagtc
1354141 attgcgccgg ggcttgtgca cctgatgaac ccgaataggg aacaataggg gggtgatttg
1354201 gcagttcaat gtcgggtatg gctggaaatc caatggcggg gcatgctcgg cgccgaccag
1354261 gctcgcgcag gcgggccagc ccgaatctgg agggagcact caatggcggc gatgaagccc
1354321 cggaccggcg acggtccttt ggaagcaact aaggaggggc gcggcattgt gatgcgagta
1354381 ccacttgagg gtggcggtcg cctggtcgtc gagctgacac ccgacgaagc cgccgcactg
1354441 ggtgacgaac tcaaaggcgt tactagctaa gaccagccca acggcgaatg gtcggcgtta
1354501 cgcgcacacc ttccggtaga tgtccagtgt ctgctcggcg atgtatgccc aggagaactc
1354561 ttggatacag cgctggcgtc cggcatgccc gtagcgctcc gccgttgccg ggtcggcgac
1354621 caaggcattg accgcctcag ccaatctggc ctggtaaccg gtcgcgtcgt cggcgtcgta
1354681 atgcaccagt gagccggtga tcccgtcggc gaccacctcg gggatcccgc cgacgtcgga
1354741 ggccaccacg gcggttgcgc acgccatcgc ttccaggttt acgataccca gcggctcgta
1354801 caccgacggg cacacgaaaa ctgttgctgc cgaaagtatt tctcgtagtt gtccgatggt
1354861 aagccggtct tggatccaaa acacgccagt gcgattgcgg gccagttcgg ccaccgcgac
1354921 gcgcacttcg tcggctactt ccggcgtgtc cgcagcaccc gcgcagagca ctagctgtac
1354981 gtccgatctg aatcggtgcg cggctgttac caggtggacg actccctttt gccgggtgat
1355041 tcgcccgacg aacaccgcca tgggccggtt cggatcgacc ccgagctcgg ccagcaccga
1355101 cccggtacgc gcgggcccgg ccggatacca cgtctcggtg tcgatcccgt tccggatgac
1355161 gtgcaccagg ttcggatcca ggctgggata gacccgcaac atgtcgttgc gcattgcaga
1355221 actgaccgca atgaccgcgt tggcggccag caccgcggtc tgctcgaccc atgtcgatac
1355281 ctggtagccg ccgccgagtt gctccttctt ccatggccgc aacggttcga gcgaatgtgc
1355341 ggtcaaaaca tgcgggatgt cgtagagtat cgcggccaga tgccccgcca gagcggtgta
1355401 ccaggtgtgt gaatgcacga cggtggccgc gctggcggca ttggccatca ccaggtccgc
1355461 ggacaaggtg gacagcgccg cgttggcgct gcctagcctc gggtcgggcc gataggcaaa
1355521 tgcgcccggg cggggtgcgc ccatgcagtg cacgtcgacc gcgcacagcc ggcgtaggta
1355581 ggcaaccagt tcggtgacat gtaccccggc tccaccgtaa acctccggtg ggtattcccg
1355641 agtcaacatc gccacccgca taccccgcac cgtagtgcgg tgacggggcg gcccgcgtgg
1355701 cgggccgagg aggaggcgga ggcggcacag cacccgtcga acggggccaa acaccttgac
1355761 ggacagcccg tcagagcagt agccaggggc ggattcccct tggcagtggt ttgcgggggc
1355821 cgataggttt gagccatgag agaagtgccg cacgtgctgg gcatagtctt agccggcggt
1355881 gagggcaagc ggctttatcc gctgaccgcg gaccgggcca agcccgcggt tcctttcggc
1355941 ggcgcctatc gattgatcga tttcgtactc tcaaacctcg tcaacgcccg gtatctgagg
1356001 atctgtgttc tcacccaata caagtcgcat tcactggacc gccatatctc gcagaactgg
1356061 cggttgtctg gtctggcggg tgagtacatc accccggtgc cggcacagca gcgcctcggc
1356121 ccgcgctggt ataccggctc cgccgatgcg atctatcaat cgctgaactt gatctacgac
1356181 gaagatccag actacatagt ggttttcggc gccgaccacg tctaccgtat ggatcccgaa
1356241 cagatggtcc ggttccacat cgacagcggt gccggcgcga cggtggccgg catacgggtt
1356301 ccacgtgaaa atgcgaccgc gttcggttgt atcgacgccg atgactccgg ccgtattcgc
1356361 agcttcgttg agaagccgct ggagccgccc ggaacccccg acgaccccga caccacgttc
1356421 gtctcaatgg gcaactacat tttcacgacc aaggtgctta tcgacgcgat tcgcgccgac
1356481 gccgacgacg accactcgga ccacgacatg ggtggtgaca tcgttccgcg gttggtggcc
1356541 gacggtatgg cggcggtcta tgacttctcc gataacgaag tgcctggtgc caccgatcgc
1356601 gaccgagcat attggcgcga cgtcgggacg cttgacgcgt tttacgacgc acatatggac
1356661 ctggtgtcgg tgcacccggt gttcaacctg tacaacaagc ggtggccgat ccgcggggag
1356721 tcggagaacc tggcgccggc gaagttcgtc aatggcggct ccgcacagga gtcggtggtt
1356781 ggtgccggca gcatcatctc ggcggcctcg gtgcgtaatt cggtgctgtc gtcgaacgtc
1356841 gtggtcgacg acggcgcgat cgttgagggc agtgtgatca tgcccggcac ccgcgttggg
1356901 cgcggggcgg tggtgcgcca cgcgatcctg gacaagaacg tcgtcgtcgg gcccggtgag
1356961 atggtcggcg tggatctgga gaaggaccgg gaacgcttcg cgatcagcgc cggcggcgtg
1357021 gtcgccgtgg gcaagggtgt ttggatctag gtccggttag cggcgcgagc agacacagaa
1357081 tcgcccattt cggcacgaaa ttgggcgatt ctgcgtctgc tcggcgcggt ggggcgcgcc
1357141 ggctagggcc ctggcggccc gggttggccg aacagctgcc cgccagcgcc gccgcgagcg
1357201 ccggccgcgg cggccccgcg ccacctccca cgccgccgtt gccgatcaac cccccgggcc
1357261 cgccgtcttg gcccggtccg ccattggcgc cgtcaccgat cgaacagtgc ctgggtggga
1357321 gcgttgatca cattcagcac gtcttgctgc acgctctgcg ccacagcagc gttgacggct
1357381 tcggcagccg cataggcccc gccagcgccg gtcagggctt gtacgaactg ctgatgaaac
1357441 gccgtcgcct gcaagctaag cgcctgatag gcctgagcgt gtctggcgaa cagtgacgcc
1357501 acgaccgccg atacttcatc ggcacaggcg gccagcatcg cggtggttgg ggctgccgcg
1357561 gcggcattgg ccgcgctcaa tgccgagccg atgcccgcca aatccgttgc cgccgatgcc
1357621 agcacgtccg gggcgccacc agatacgaca tggccacacc ttatcgtggg ctcgttacgg
1357681 catgcggtgt tttcgacgga ctcgtcaccg acgccgcgcg tgtgacgcgc gccgtcagcc
1357741 agcgctcggc aacccgggct acccagggac ctccggtatc agcaggtgcg cgtcgtagcg
1357801 tgggccccag tgcagcgtga cacgaccacg cggcgggcgt gggtaggcgg ccgggaattg
1357861 gccggtgagc gggttgcggg gggacaacca gcgtccgcca accaccagtc gtaactgttc
1357921 gccggcgcgg aacaatgtcg ccgacgggcc aagcgcgaca tcgacggcga cgacctcgcc
1357981 ggcggtgacc ggccggggcc gagcacacgc cgggaccggc tcccatggct gcgagagctc
1358041 ggggtcgagc tcgcgcagcg agacccgctg ccagccggtg gtcacccggt cacggcccca
1358101 gccgtaggac ccctcaaacg caacgaactg gccatcgcgc cacttctcca ctccgacgaa
1358161 caggttcgcg tcgtcgcagc catccaattg aacccacagg cgggcggcca tcgggccggt
1358221 caactcgatg tcttcgggga tcgtccaatt gaatgctgct gcccgagagc gagtttggaa
1358281 cctgatgctg cccgccgtcg gcggcggctc ggttgccagc agccccggcc cggcgagata
1358341 cattggccgc caacgcgtgc cggcaagcgg ccactgggtc tcttcacgca ccgcggtgat
1358401 ggtgtcgcga tcctcacgca cctcgaggcg aacgctgcgc gaaccggagg agccggccag
1358461 cgcgtctcgc aagaacttca gctgctcgga cagcgcggtc gctgagtaga aggtctccca
1358521 tttgcccccg cgatgggtat acagccgggc gtgaccgcag ccgctgcggg taaaagcgcg
1358581 gatcgacccg cggctgtgca agttgttgtc cgagaagcta ccgcagacca gcatcggaac
1358641 cttgatcgcc gacaggtcgg gtactcgcga gcgccagaaa tcgtcgcgca gcgggtgagc
1358701 ctcttgcatc tgctccatgt cgtaggtctg acgtgtgcga cgtcgcaccc cgcgcgacca
1358761 cagccgggtg aaccctgact cccggatgcc gccgggaaag gccaagtcgc ggtaggcgtc
1358821 ggtgaaaccc tcccacgggc agatcgcccg cagcgccggc ggttgcagcg cggccacggc
1358881 gtactggcta atggccagat aagacacccc cagcatgacg acgcgcccat cactccatgc
1358941 ctggtcggcg agccatccca ccaggtcgta ggtgtcctcg gcttcctggt gtgacagcag
1359001 gtctccggta ccgtcggagc ggccgcagcc gcgcgaatcc gcattgacca cgacgaagcc
1359061 ctgcgcggtc caccacgccg ggtccggcgc ctcccagccg gtcagcgccg agaaggtcag
1359121 cggcttcggc tggcgcagca tccggtattg tggtgagaac gtccaccggt tgccccgccg
1359181 ccgcggcagg gcgtccttgc cgtagggatg gatgctcgcg atcaccggcc tagccccacc
1359241 ttcggcgcta cgaaagacgt tgatccgcag cagcgttccg tcgcgggtag gcacctcgac
1359301 gtcgcgttct atgacgacgt cggccggcgg atcggtgacg gtgatcggcg gcttggcgac
1359361 gccgcgaacc cgctccagcg cataccggag agcaccggga cgtcgccacg gccggtccaa
1359421 ggcaggtgac gggtttctgg ccacgcccgt taccctaaag ctattcgacc gctaccacac
1359481 gtagggcacc aaccggtagc gcaccagttg ccggtattcg cggtacccgc tgagttcttg
1359541 cgtcagtagt ttttcctcgt cgaggatgcg gaacaccaac accagtgtgc cggggacgag
1359601 gatgaacatc gcccagtaag agcccagtgc cagcggtatg cctgtcatca tgaccacgtt
1359661 cccggcgtac atcgggtgtc ggacaatttt gtagagaccg tcggaggcca atatctggcc
1359721 cgcctccacc ctgaccgtcg aggcggcata cctgttctgg atgaccacca gcatggcgat
1359781 gccaaggccc gtcatcacta ggacgtcgcc gatcacgcac accgcggctg gcactgacga
1359841 ccaaccataa cgatggtcgc acgcgctcag caccatcatc gcgaagaacc ccagaaaagc
1359901 gccgatgacg atgaacttct gaatcgttcg gccctccgcg agcggaccgc tgcgcatgcg
1359961 acgttgaagg gccgcgggat cgttgcgagc cagatagatt gtggggccaa tcgtggtgct
1360021 cacaaatgcg gcgaggaaca cccacgcctg ccaatagtcg aacgtgccgg ctggcccgaa
1360081 taggagcgcg ccgaaaacga cgagtcctaa cacgccccat atgaatatct tcagcccaat
1360141 gtgcatggct cctcctagca gcgaacgtca cgccgtcgga aggccatggc gcccagggtg
1360201 atcagggctg catctatggc cagcagccac agcaacggca ccgcggtgaa atcgccgccg
1360261 ccgacccgcg ggatgtgggc gaacggctcc aggttgagca gcatctgcgg gaaccccgcc
1360321 aacgagccga gcaggtacag cgcgatgaac ccgaccagca cgccccacgc caccggcgtg
1360381 aaccgcggcg ccaacccgaa caatcccacg gtcaccgccg ataacaacca cacggccggc
1360441 agttgcacgg ccgcggtgcc gaccacggtg ggcagcttgc cgccgacgtc accgacggtc
1360501 atgccgtagg cgagtccggc cgccacgccg gagatcaggg tcgccaccgc cgatccggcc
1360561 agcgccatcg ccagatggct tgccagccaa tgggtccggg aaaccgcccc ggcgagcagg
1360621 gtctcggccc gcagcccggt ttcctcttgg tgcagtcgta gggtcagcga gacggcgaat
1360681 gcggcggcga ccatgccgat catggtgaag gccagcgcaa ggaaggcctg ttccagtgcg
1360741 ccggtgccgc ccatccgggt gacgatgtca cgcaccgcgg tgttatcgcc cagctgatcc
1360801 ccgatgccgt gcaccacact gcccatcacc agcccgtaca ggcacaggcc gacggtccac
1360861 aacagcaggg agccgcgatt gagccgccat gccagcccga agggctcgct cagcatgggc
1360921 ccggcggtgc cggcgccggg gcgttcggcg atcagtccgg caccgacatc acggccggcg
1360981 cgtaatcgat aggccagcac ggtaagcacg gccgcggtcg ccagcgacag cagcagcacc
1361041 caccaacgct ctcccgcgta gggtctgacc tgcagcgacc accccagcgg cgagcaccag
1361101 gacagcgtgc ccgagccggc atcaccgatg gcacgcagcg cgaacgcggt gcccaggacg
1361161 gcgaacgcga ccgcgcgggt gaatcgggcg ctcggcgaca gctgcgcggc caccgcggcc
1361221 accgccgtga agaccatccc ggaggccgcc agcgccacgc caaacgctac cgacccggcc
1361281 ggagccacat cggtggcaag cagacccaat gcaccgatcg cgccggtcgc gatcgacgca
1361341 ccgaacgaca gcagcagcgc gccggtgagg ttggcgtagc gcccgaccac ggtcgaatcg
1361401 atcaattcgg cacggccgct ttcctcgtcc gcgcgggtgt gccgaatcac cgtgaggatg
1361461 accgccaccg cgatgagggt gtgaaacatc ccggctttcc agattccgac cgcacccagg
1361521 ctgtcgttgt agaccggccc gtagagcgcg cgctgtgccg ggctggccat aatggcggcc
1361581 gccgcggcgg cgcgggcgga ccggtcgggg taaaccgttt cgacgctggc gatgtacacg
1361641 gtggccagcg gcaccgacag cagcagcacc cacagcggca acgacacccg gtcgcggcgc
1361701 aggtacaggc gcagcaaccc cagtgtgccg gtgaagcccg aaccgcggtg tggtgcacgg
1361761 tgtcctgcgg gtctcgcgcg atcgatgacc gtactgctca cggcgttgcc acctgttgct
1361821 cggctgcgac ctcggggccc aggctgtagt ggcgcaggaa cagctcctcc agggtgggcg
1361881 gctgactgac caggctgcgc acaccggcgt ggccgagcac ttggatgagt tctctcaggc
1361941 tttcgctgtc gacctgggcg cgcactgtgg tgccctcgat gctgatgtcc tcgactccct
1362001 tgatttggct gaggtctcct ggatcaccga tcatttcggc cttgatcgag gtgcggctga
1362061 ggtgccgcaa ggcgtctagt gaaccgcttt cgacggtctt gccggctcgg atgatggtca
1362121 ccttttcgca cagcgcttcg gtctcggcca gaatatggct ggacaacagc accgtcacac
1362181 cgcgttggcg tgcttcgccg atgcactgct gaaacacgtt ttccatcaac gggtccaggc
1362241 cgctgctcgg ctcatccaag agcagcagag tggcgtgcga cgacaatgcc gagatcaggg
1362301 agaccttttg gcggttgccc ttggagtagg tgcgcgcctt cttggttggg tccaggccga
1362361 agcgctcgat cagttccgcg cgacgagcgt tgtcgatgcc gcctcgcatg cgggccagca
1362421 ggtcgatggt ctcaccaccg gtcagcgacg gccacaatgt gacatcgcct ggaacatagg
1362481 cgatgtggcg gtgcaggtcg acggcgtcgg tccaggggtc accgcccagc aaccgcacgc
1362541 ttccgccgtc ggccttcacc aggcctagca ggatgcgcag ggtcgtggac ttgcccgcgc
1362601 cgttggggcc gaggaagccg tgcacttcgc cctcgcgcac cgtgaggtcg agcccgtcga
1362661 gcgcccgcac cgacccgaag tgcttggtca gtccgcgaat ctcgatgggc acctggtggt
1362721 tgtcagccga catgtgcttc tccttgttga gcttcggcca ggaaggcctc gtacatggcg
1362781 cggtcggcca gcaggccttc ggtgtagacc tccagggaag gcagcaccat gtcgtgcgcg
1362841 tagtcgcgta acgctgcacg gagatcggtt gggttttcgt gcatttgcag ataaagcagg
1362901 aagcctccgc ctccggtgat cgccagaaac cgagcacggg cgcgcgggtc gcggctgggc
1362961 ttgaccgtac cggcgcgtac tccttcgtcc aggtactcct cggcgttgtc gatcatcttc
1363021 tgccacagca tcttcgccag ctcgccgccg gattgcatgc tgcgcaccag gtatgccatc
1363081 agcggtgcgt aggattcgat ctcggccatc tgcgcgagcc aggtggtcgg gtcgttggac
1363141 ttcagtgccg cagccttgct gctgcggatc tcttcggcga cgaagtcgtc gcaggccttg
1363201 cgcagacctt ccttggaacc gaaatggtgg atgaccaatg ccgcgctcac ccccgccgct
1363261 tcggcgatgg ctcgcagccc gacaccgaat ccgtgccgac cgaactgttc gatggccgcc
1363321 tctctgatcc tggcgtgcgc ggtcagatcg gctgaacgca tgttcaggat attaaacgta
1363381 cgttcatccc cggtcaaggg agggcgccgt tgggaatccg tgaaggccgc gaactttgcc
1363441 gagcagacgc aaaatcgccc tggaacgcac ggttcagggc gattttgcgt ctgctcgccg
1363501 aattagtccc gcacggctgc cagcacgccg tcgcccagcg gcaccagtgc cggagtgagc
1363561 cgttcatcct cggcgataag ccgggccgcc tcgcgaaccg cgatcacctc ggcgtcgcgc
1363621 gccccgggat caccggcccg accgcccagc gccgcccggt gcacgacgat gaccccgccg
1363681 gatcgcagca gccgcacccc ctcggcgacg taatctggct ggtcgatcgg gtcggcgtcg
1363741 atgaatacca ggtcgtagga tgcgtcggcg agccgggtca gcacctcttg ggcgcggccg
1363801 ctgatcagcc tggtacgcga cggcccgatg cccgcctcgg caaaggcctg cctggcaagg
1363861 cgtagatgct cgggctcgat atcgatggtg gtcaagacgc cgtcgtcgcg catgcccgac
1363921 aacagccaca ggccgctgac gccggccccg gtacccactt cggccaccgc cttgcctccg
1363981 ctgagcttgg ccagcaagca cagcaacgca cccaccgccg gtgttaccgc cccggccccg
1364041 atgtcggttg cgcgctcgcg ggcgccggcc aggatcacgt cttcagatat tgacccctcg
1364101 gcgtgcgccc agagtgattc gcctcggctg ggggccggct ggccaggcat gtcgtcgtgt
1364161 ccgggggtgc cgtccatgcc cgcagcgtat gtccaattgg cgacgccgtc gggcaggcgc
1364221 gcctggttcg aacgccggcc gagcaccgag ctggacgctt gcggctgtac ccgacacgcc
1364281 cggcgtgccg gacgcgacga aggtcacttt gactcgatat tccctggaca gcgcaggtaa
1364341 cggtatggtt tctaagccaa agctcagatt gctcatatat ggcccatacg ccggtacgcg
1364401 acggtaattc ccatggaact cctcggcgga ccccgggttg ggaatacgga atcgcaactt
1364461 tgcgttgccg acggtgacga cttgccaact tattgcagtg caaattcgga ggatctcaat
1364521 atcacgacca tcacgacctt gagtccgacc agcatgtctc atccccaaca ggtccgcgat
1364581 gaccagtggg tggagccgtc tgaccaattg cagggcaccg ccgtattcga cgccaccggg
1364641 gacaaggcca ccatgccgtc ctgggatgag ctggtccgtc agcacgccga tcgggtgtac
1364701 cggctggctt atcggctctc cggcaaccag cacgatgccg aagacctgac ccaggagacc
1364761 tttatcaggg tgttccggtc ggtccagaat taccagccgg gcaccttcga aggctggcta
1364821 caccgcatca ccaccaactt gttcctggac atggtccgcc gccgggctcg catccggatg
1364881 gaggcgttac ccgaggacta cgaccgggtg cccgccgatg agcccaaccc cgagcagatc
1364941 taccacgacg cacggctggg acctgacctg caggctgcct tggcctcgct gccgccggag
1365001 tttcgtgccg cggtggtgct gtgtgacatc gagggtctgt cgtacgagga gatcggcgcc
1365061 acactgggcg tgaagctcgg gacggtacgt agccggatac accgcggacg ccaggcactg
1365121 cgggactacc tggcagcgca ccccgaacat ggcgagtgcg cagttcacgt caacccagtt
1365181 cgctgaacta ctcaacggcc gccgagcgcg tcggttcggc taccgcatgg ttgccaatcg
1365241 gtcccgaatc ctggggtttt accggctggc gatggttttc cggcaccgcg ccgcgctaca
1365301 ttcgagatac cggtggctcg ctaggtggcg gaaggaggtg gtgatggccg accccggaag
1365361 cgtgggacat gtgttccggc gcgcgttttc ctggctcccg gcgcagttcg cctcccagag
1365421 tgacgcgccg gtcggcgcgc cgcggcagtt ccgttccacc gagcacctgt caatcgaggc
1365481 catcgcggct ttcgtcgacg gcgagctgcg gatgaacgcg cacttgcggg ccgcgcatca
1365541 cctttcgctg tgtgcccaat gcgcggccga agtggacgac caaagtcgtg cccgcgccgc
1365601 tctgcgcgat tcccacccga tccgcatccc cagcacgttg ctcggattac tgtccgagat
1365661 cccgcgttgt ccacctgaag gtccatctaa aggttcgtct ggaggttcat cccagggccc
1365721 gcccgacggg gctgcggcag gcttcggcga ccgcttcgct gacggcgatg gcgggaatcg
1365781 gggccggcaa tcgcgggtgc gtcgctagcc ggtgagccac ttgtcgcagc gcatggcggg
1365841 gttgctgcga gttcatggcg agtggtcgcg atccgtggat actagggtgg acacggacaa
1365901 cgcgatgcct gcacgtttta gcgcccagat tcagaatgag gatgaggtga cctccgacca
1365961 aggcaacaac ggcggcccga acggcggagg ccgcctggcg ccgcgcccgg tttttcggcc
1366021 accggtcgac ccggcgtcgc gtcaagcgtt cgggcgtccg tccggggtcc aagggtcctt
1366081 tgtggccgag cgtgtgcgcc cgcagaagta ccaggaccag tctgacttca caccgaacga
1366141 tcagcttgct gacccggtgc ttcaggaggc gttcggtcgt ccgttcgcgg gcgccgaatc
1366201 gctgcagcgc catcccatcg atgccggagc gctggcagct gagaaagacg gtgccggccc
1366261 cgacgagccc gacgatccgt ggcgcgaccc cgcggccgcg gccgcgctgg ggacgccagc
1366321 gctagccgcg ccggcaccgc acggtgcgct ggccggcagc ggcaagctgg gtgtgcgcga
1366381 cgtgctgttt ggcggcaagg tgtcctactt ggcgctgggc atcttggtcg ctatcgcact
1366441 ggtgatcggc ggcatcggcg gtgtcatcgg ccgcaagacc gcggaagtag tcgatgcgtt
1366501 caccacgtcg aaggtgaccc tgtcgaccac tggcaatgcc caggaaccgg ccggccggtt
1366561 caccaaggtg gcggccgccg tggccgattc ggtggtgacc attgagtcgg tcagcgacca
1366621 ggagggcatg caaggttccg gcgtcatcgt cgatggccgc ggctacatcg tcaccaacaa
1366681 tcacgtgatc tctgaggcgg ccaacaatcc cagccagttc aagacgaccg tggtgttcaa
1366741 cgacggcaag gaggtgcccg ccaatctggt gggtcgtgac cccaagaccg acttggccgt
1366801 cctcaaggtc gacaacgtcg acaatctgac cgtggcccgg ctcggtgatt ccagcaaggt
1366861 acgggtcggt gacgaagtcc tcgcggtcgg cgcgcccctg gggctgcgca gtacggtgac
1366921 ccagggcatt gtcagcgcgc tacaccgccc cgttccgttg tcgggcgagg gctctgacac
1366981 cgacaccgtc attgacgcaa ttcagaccga cgcctcgatc aaccacggta actccggcgg
1367041 tccgctaatc gacatggatg cccaggtgat tggcatcaac accgccggta agtcactgtc
1367101 ggatagcgcc agcgggctgg gctttgcgat cccggtcaac gagatgaaat tggtggcaaa
1367161 ttctctgatc aaagacggaa agatcgtgca tccgacgttg ggcatcagca cccggtcagt
1367221 aagcaacgcg atcgcgtcgg gcgcgcaggt ggccaatgta aaggcgggaa gtcccgcgca
1367281 gaagggcggg atcttggaga acgatgtgat cgtcaaggtc ggtaaccgcg cggtcgccga
1367341 ctccgacgag ttcgtcgtcg ccgtgcgcca gttggctatc ggccaggacg ctccgataga
1367401 ggtggtccgc gagggtcggc atgtgacgct gacggtgaaa ccggaccccg atagcaccta
1367461 gagtgttcgc caacatcggt tggtgggaaa tgctcgtcct cgtcatggtc gggctggtgg
1367521 tgcttggccc ggagcggctc ccgggtgcca tccgctgggc ggcaagcgct ctgcggcagg
1367581 cgcgcgacta tctcagcggt gtgaccagcc agctacgtga ggacattgga cccgaattcg
1367641 atgatctgcg gggacatctc ggtgagctgc agaagctacg gggaatgact ccgcgggctg
1367701 cgttgaccaa gcacctactg gatggcgatg attccctgtt caccggagac ttcgaccgac
1367761 cgacgccgaa gaaaccggat gcggcgggct cggcggggcc ggacgctact gagcagatcg
1367821 gtgcggggcc catcccgttt gacagcgatg ccacctagat cggtgacggc cggcggtcgg
1367881 gcccggcgag ctaacacccg agcaacggcg gcaggccggc caccgagtcg atcacgtggt
1367941 gcggccgggt cgcgctggcg ccggccagcc agcgatccag cgtttgctgg cggaacttgc
1368001 cggtgcgcac cagcacaccc gtcatgccca ccgcctgggc ggccagcacg tcgttgtgca
1368061 gatcgtcgcc gatcatgacc atctgctgtg gatcgacacc gacgcggtcg gcggccgcca
1368121 ggaatccctc ggccgcaggc ttgccgatgg cggtggcggt cttgccgcag gcctgttcca
1368181 ttccggtcag gtacatcccg gtgtcgatgc gcagcccgtc ggtggtgttc caggtcatat
1368241 tgcggtgcat cgccaccacc ggaacgccgt cgagcatcca cccatagacc cggctgagcg
1368301 tgcggtgatc gaactggggg ccggcactgc cgagcacgac gacgtcgggg gcttcggggc
1368361 aatcctcggg accgatctcg gtcgacaaga cgacgtcgat gccgggcaag tcctcggtga
1368421 tgtcgccgtt gttcaccagg aagcaccgcg cgccgggata ggcgccgtgc aggtactcgg
1368481 ccgtcagcac cccggccgtg atcacgtcgt cggcggcgac ggggatcccc gcggcaccca
1368541 gcgcctcggc gatctgccgg cgggtgcgcg tcgtggtgtt ggtcagatac gcgcaggcga
1368601 ttccccgatg ggtcagttgc cgcacggtct cggcggcccc gggaatcgcg cgccacgaca
1368661 gcaccagcac gccgtcgatg tcgaacagca ccgccgcggc catcagatgc gccacgtcca
1368721 cacgatatcc gtcagttaga ccgtcgacat cgacaccagc gcggaaaaac cccagtgagc
1368781 atcgcgctga cgtcgatctc gacggtgagg ttcatcctgg ctcaggatcc ctcaagatcc
1368841 gtggcgcaac cacacactgt cggccaccca gggcgacgcg gcgccggcca ccgaccacgc
1368901 cagctccgcg ggcacatcga gcacctgata acccttgcgg cccgccacgg tggccgccac
1368961 gagcgtcgcc acccccgccc tccgctggaa cagtgtctgg cgcaccgtcc agccgatgat
1369021 gccggtgcag gcgatgcaat cgcggcgacg ctgtaggctg ccggcgcgcg caaccaacca
1369081 gccgtcggcg acgcggtgcc cgagtgatcg gacccgatcg acggccagcc cagcgcaacc
1369141 cgcggtcaac accgcccaca gtgtccacgc ccaccccggc acgccgagaa tcggcgccgc
1369201 tgcgatcagc gcaactccgg ccagcgtcgg gaccaacagc gcccgggtcc acctgcgccg
1369261 ggcggcggcc gggccgtgcc ggcgcagcgg ccccgctgcc gcgtcggtgt tgtcgatcag
1369321 gtcggtcagc acggccgtcg cggtctcgaa cggacatggt ggcagcagca tcgacgactg
1369381 gccctcgcca tgcacgccgg tcatcactgc gtccagccga gcaccgcgca ataaccgcac
1369441 cagcagtggt tcacgcaagg tggcgccacg cagccggcgc atgtcgtagg tgtgctcgcg
1369501 cacccgcagc agcccgtgcc gcaggtgtag caccccttct tgaccgctgc cgccgcggcg
1369561 cagcagcaga ttgccgtagg tcaaccagga gaacagcacc gccaacagtg ccgatacacc
1369621 caccaccagc agcacagtga ccgccaccac cagtaccacc ccggcgcgtt gcgcggcgtc
1369681 caccgcggac ctggcgaaac cggattccgg gagtcgcacg gccagtcccg tttggtagcc
1369741 aagcccgatc accgccccga tcatcaccag gcccgaaaag ctcagcggcg cataccgcaa
1369801 ccacgacgac tgccaccggg ccagcacccg accggtcggc tcgacgggtg ccagcgactc
1369861 ggccagcagc agcgcgcgca gcctgggcac ccgtgccgag tcgaccgcgt ccagttcgaa
1369921 ggcggcctca ccgcgggcct cctggccggt gcccacccgc agcaccgtca accccaacag
1369981 ccggtgcaac agccgcgcct cggtctgcac cgagcgaatc cggttgcgcg gcacggagac
1370041 cgcgcgccgg ctgagtatgc cggtacgcag cgacacgttt tcgtcgtcga tgcggtaggt
1370101 ggtgaaaaac caacgcagca cgccgaatac gaccgtcacg ccgagcgccg ccagcggcca
1370161 gaccgggttg ccggttgccg accccagcac cacggacccg atgagtaccg ggagctggcg
1370221 cagcatctcg tgcaccggat gcaccagcag catccgcggg ctgaggcggt gccaatcgtg
1370281 tggccggtcg gtcatgtcgc gtcctcgccg cgcagcgcgg cgatgtcggt cagctgcgcc
1370341 accacccgat cggcgacgtc ggtgtccaac gcctcgatgt gcaccgcgcc cgccgaggac
1370401 gccgtggtta cggtgacgtt ggccagcccg aacagccggt ccatcgggcc gcggtaggtg
1370461 tcgacggtct gcacccggga aatcggtgtg atgcggcgct cctgcacgag ccaaccggtg
1370521 cgggtgaata cggcctgcgg gctgatctcc caacggtgta cccggtaacg ccagagcggg
1370581 accaccccga tgtgcaccac catcgccacc gcggtgagag cggccgcggc caggtgcggc
1370641 cagggcggct ggggatgcac cgcccaccac accagctgcg cgatcaccgg gagtatccag
1370701 cccagcgacg cggacagcgc ccacatcacc ggcgcctggc tgctcggtcg atgggccggc
1370761 tcggcgagcg cgaggtgatt tctctgcggt ccggttgcgc ttggcacatt tcgagcatgg
1370821 tccaacggaa accgaacaca gtgatcgggg gtcgtggtta tcgtttgagc tagcgctcaa
1370881 caagatgcgt gccaactcac cctgccccgg ggaggcgcga tgagtcgaca gtggcactgg
1370941 ctggcagcga cgctgctcct gatcaccacc gccgcgtgca gtcgtccggg caccgaggaa
1371001 ccggattgcc cgacgaaaat aaccttgccg cccggtgcta cgcccaccac gaccctcgac
1371061 ccgagatgca tagtgcgcgc gaccaccacc ggcacagccg acggcgatgc ggcgtcgcgc
1371121 tggaccggaa ccgtgcggat cgccgggttc tatgcctcga tctgcaacgc ggtatgggac
1371181 gggaacgtca gccttgcggg aaaggacgag ctgaccggca aggctacgct tatcctcgtc
1371241 gaaaccagtt gcccgggcaa ggttgtcgcc ggcgaactcg tgctgaaggg gaacgtcggt
1371301 tcggacagcc tcgcgatcac ctgggcgcac cccgaactcc cgcagcgggc gttcgacctc
1371361 ggcgccggac agggcacgat ccgccgatcg ggcgaccgtg ccgagggaac gttcaactcg
1371421 gatatgggtg ggggcaccga gttcttcttg acgtggtcgc tgacgatgcg taactgacga
1371481 tcacaacgtg cccaccaaaa acagagtaga caacagtcga caattccctt gtactccggc
1371541 gctatgaagt cgatctccgt cggtgagctg cgccagaatc ccgctcccat gatcgccgac
1371601 ctcgaacggg gtgagccata cgcgctgacc cgccacaacc accggatcgg aacgatcatt
1371661 cctgccgtct cgtcggcaac actcattccc cggaaagcct agtacgccga gcagacgcaa
1371721 cggcacccaa tttcgaccag aatcgggttc ttttgcgtct gctcacgcgg tcaacgctag
1371781 cgtcgtgtcg ggtccaaccc cagcgacatg cccgccaatc cgcgtcgtcg agtcgacaag
1371841 ccgtcggcga tgctatgcag ttccttgccg atcgccgagt ccggcgagct caacacgagc
1371901 ggtacgcccg aatcgccggc ggccaccagt gcggggtcca gcgggatctg acccagcagc
1371961 ggcacgtcgg cgccgaccgc acgcgacaac cgctcggcga ccagccggcc accgccctcg
1372021 ccgaacacct gcatcgtggt gccgtccggc agcgtgagcc ccgacatgtt ctccacgacg
1372081 ccgacgatgc gttggcgggt ttgcagcgcg atgctgccgg cccgttcggc cacctccgcg
1372141 gcggccagct gcggggtggt gaccaccagg agttcggcgt tggggatcag ttgagccacc
1372201 gagatggcga cgtcgccggt tccgggcggc aagtccagca gcagcacgtc cagatccccc
1372261 cagtacacgt cggccagaaa ctgctgcaac gcccggtgca gcatcggccc gcgccacacc
1372321 accggggtgt tgccctgggt gaactgggct atcgagatga ccttcacctg gtgggcgatc
1372381 ggcggcagga tcatcgactc aacctgggta ggccggtcgg tggtgcccat catccggggg
1372441 atagagtggc cgtggatatc agcgtccagc accccgatcg acaggccgcg gacggccatc
1372501 gcggcggcca ggttgaccgt gacggtggac tttccgactc cgcccttacc ggaagccacg
1372561 gcatacaccc gggtcaagga atcgggttgc gcgaacggga tgacgggttc gcgggtatcg
1372621 ccacgcaact gcttacgcag ctcggtgcgc tgctcgtcgc tcatcacgtc caagctgacc
1372681 cgcaccgccg aagtgcctgg cacgtcggcg accgcccggg tgacacgctc ggtgatttcg
1372741 gacttcttcg ggcagccggc gatggtcagg tagatctcga cgtgcacgct cccatccggg
1372801 ccggtgtcga tgcttttgac catccccagt tcggtgatgg ggcgccgcaa ttcggggtcg
1372861 attaccttgc ccagcgcggt gcgtatcgcc gcgttcaggt cgccatcacg agttccggac
1372921 atcaccgccg agtgtaggcg gcttggcata cggccgagtg gtcagccggc aggagccggc
1372981 gccggcggcg ccaggcccgc gtcgccaggc gggccggcca atggatccgg aggtggggga
1373041 gcggcaggta ggaatggagg tgggggagcg gtaggcggga acggcggcgc gcccactggc
1373101 gggccatgtg agccaatgca gatcagcgtg cagccgggca tcggcgccga tgggtcaggt
1373161 gccatccacg ggaacatcgg cggtggattg agcgccgcct ggcgcggggt caagtcgatc
1373221 agcggcaggt gcgccatggg gccatcggcg gtcaggccgt tgacattgat cggcaagccg
1373281 ggcccgagac cctccggatt ctcgaggtgc gcgtcgccga gtggtggtgg cggaccggtg
1373341 atcgggggca agtcaaccgg gaacacaccg gtggcgtagc cggcggccca gcccagtacg
1373401 ttctgggcgt aaggcatcga gttgttgtag cgcaggagcg cggccatgac ctgcgccggg
1373461 tcgcgcaggt tgagcccacc gctacacagg tagcgggctg cggccaacgt ggagtcgaac
1373521 aggttctgcg ggtcagccac accgtcgtca tcgccgtcgg tggcgtaccg agcccaagtg
1373581 ccgggcaaga actgcattgg ccccatcgcg cgggcgtacg tgacgcgatt gccgacgctg
1373641 ctttggatga tgatctcgtt gcctggcagg gtgccgtcca gcgttgggcc gtagatcggc
1373701 tggatcgcgg tgccgcgcgc gtcggtggcg ccgccgtttg cgtgcatcga ctcgatgcgc
1373761 ccaatcccgg ccagcaagtt ccaactgacg ccacagccag gggcggcagc ggccatcttc
1373821 agctcggcgt tgcggtaggc ggacagtgcc atggccggaa tgccaagcgc accaggcgaa
1373881 ttcacgatca tcggtggtgg tggagccgat atggtagcta ccgccacgcg gaagctggtc
1373941 ggcgggcgct tcatggcgat gacgaccgga ccggacaggt ctatgccgga cgcggcgacc
1374001 gcggccaccg gggtgataac ggcgtgcacc ggcgcggttc tcccggggaa taccggagcc
1374061 gcgctgccga ccgcactggc gaataccaac ggggcaatcg ctgccacgcc gaatgccggc
1374121 gcccgcgtta ggcgacaagc tccccgccgc actgcagcga cggccgggcg tgcaccccag
1374181 cgtcccccaa tgtgcactcg accgtcctca gtgtgtgagc cgtcggaaac ctatgtcttc
1374241 ttagcttctt tcttcgtttc gtgaactaga tcaccataca taactcttgt cacgggagtg
1374301 gcgcaatggc cgactcggta atcaccccga tttcttggcg tgctgctccg cctcgtcggc
1374361 cacccgcggc tgcgccacat ccggatccgt cggctgcagc tccgccaaca gagcgcgcag
1374421 gctgtccagt tcgtggcgca ggtagtcgcg cgtggggacc tcgccgatgg ccagccgcag
1374481 cgctgccagc tcgcgggcgt tgtactcggt gtcggccttg gtctgtgcgg cccgccgacg
1374541 atcctcttcg aacaccgcgc ggtcacgctt ttcctgacgg ttctgggcga gcagaatcag
1374601 cggtgcggcg tacgaggcct gcgtggagaa ggccagattg agcaggatga aggggtacgg
1374661 atcccagcgc aagccgaccg caaacaggtt cagcacgatc catgtcagta cgagcagcgt
1374721 ctgcaccagc aggtaacggc cggttccgaa aaaccgtgcg atggattcgg ttgtcctgcc
1374781 gacggcctcg ggatccagcc gcggggcgag cgtgcgcgat gtgcgtgggg tgtacagacg
1374841 gcgcggcgcg aagggtttgc tcaccgtggt cctccgggtc tgtccggtgc tccggagggg
1374901 tcgagctccg gcatatctac acgccagtca tgcggcaata gatggtcgag caggtcgtcc
1374961 acggtcaccg ctcccagcag gtggttctcg tcgtcaacca ccggtccgca caccaggttg
1375021 taggcggcga agtagcgagt caccgcggcc agcggggtct ccggagtgag cgtgagcagg
1375081 tcagtgtcca caactccgcc gaccagctcg gccggcgggt cacgaagcag ccgctgcaaa
1375141 tgcacacaac ccaggtagtg cccagtgggc gtggccgtgg gcgggcgcgc gacgaacacc
1375201 attgacgcca gggcgggggt gagatcggga tcgcggaccc gcgccaacgc ctccgcaatc
1375261 gaggtgtccg gggtcaacac caccggatcg gaagtcatca atccgcccgc cgtgtcgggg
1375321 gagtgcgtca gcagccttcg cacctgcccg gagtcgccgg gatccattcg tgtcagcagc
1375381 aactcggctt cggtcggatt caggaccgcg agcagatcgg cggcgtcgtc gggatccatc
1375441 tcctccagca cgtcggccgc gcgttcggtg cccagttgcg acaacacctc ggcctgatcc
1375501 agttcgggca gctcctgcag gacgtcggcc aagcgcttgt cgtggagcgc cttgaacacc
1375561 tcgtggcggc gcttcggcgg cagcccgcgg atggcgtcgg ccacgtcgac cgctttccat
1375621 ccctcgaact ggtcgagcag ctgtgccacg tcttgacccg gcatcgccaa ggccgacggc
1375681 gtcaaccccg ccacgttgtg ccagtccacg acgtgcactg ggcagcgccg tcggagccga
1375741 cgttgggtgc ggacggcgac cctagtcacc atccagtcgc gacttcgggt ttgctcgaca
1375801 cccaggtcgg tgaccacgac gtcgacgccg gccagctcgg gtagtgcggg atcgttgacc
1375861 ttcaccaggg tgtcgagcac ttgacccagc gccagagcct cgcctggccg ctgctcgaag
1375921 cggtgcagtg acacgttgcc ggtgctcagt gtcaccgcgt gcggctcgat cgcggcgacc
1375981 cgcagaatcg gtatgaatat cttgcggcgg gtcgccaaat cgaccaccag cccgagcact
1376041 cgcggttgtt ggcggacaat gctgatgctg atcacgacat cgcgaacgcg cccgaaggat
1376101 tcgccgagcg gtcccagcac cgacatccgc gagagccgcg ccaggtacac cctgttgacc
1376161 gatcccatga ttgagagcct aggcagctgc cttccggatc aaccgagggt gggccaatgt
1376221 cgcctaatgc taagggatag cgaagatccc cgcgatcatg tagaccagca gggtcgcgat
1376281 gccaatcaca atgccggcca ccgccaggcc gtagccttct tcgcgtgtct gcttgatctg
1376341 gttgatggcg atcgcgccga acacgatgcc cacgatcgag ccgatgcagc aaagcacacc
1376401 gacgagcgcc gagatcagtg agacgagcgc catggtgttc atgccgggct gcgatgggcc
1376461 gtagccgtct aggtagcccg gctccgggta gtagccgccc ggagatccac cgtatggcgg
1376521 aggcatgggc gggtatggta tgtcgccgta gcctgctgaa gaagtgccgg ggggtggata
1376581 tccgggcggc gcatagcccc cgggtggcat cggcggtgga tagccggtcg gatacccggg
1376641 ctggtaagca ggcgggtaac cggacggcgg atacgccggg ggcgggtggt tggccatcgg
1376701 cgaagatgcc ggcggcgccc aaggagcgtc agcaatgggc tgttcggggg gccgctcacc
1376761 gaccggaggc ggtccacccg cggcgtcgtg cgcactctcg ccagaggagc cgctgggagc
1376821 cgtcatggtg atcaacctat cccggcaacg atgctcgccg ttcggtgggc ctcggtcgct
1376881 cgcgggttga gtggatagtg tgccgggagt agctggacct gactggacat gaaacgatgg
1376941 cgctgaaaaa ggggggcgga ggagaatgag aaccgatgac tagcccattc cagcccagac
1377001 aggttcccgg ttcaacaccc gccgccgcag gtgcgggtcg acgtggtgtg cccgcattgc
1377061 ccaccccgcc gaaaggttgg ccagtcgggt cgtatcccac ctatgccgag gcgcaacgtg
1377121 cggtcgacta tctatccgaa cagcagttcc cggtccagca ggtgaccatc gttggcgtgg
1377181 acctcatgca ggttgaacgg gtcacaggcc ggctgacctg gcccaaagtg cttggtggcg
1377241 gcgtgctgag tggcgcctgg ctgggcctgt tcatcgggtt ggtgctcggg ttcttcagtc
1377301 ccaatccatg gtccgcgctg gttaccggcc tggtggccgg ggtgttcttc gggctgatca
1377361 cctctgcagt gccgtacgca atggctcgcg gcacaaggga tttcagctcg accatgcaac
1377421 tggttgccgg tcgctacgac gtactttgtg atccgcaaaa tgcggaaaag gcacgggatc
1377481 tgctggcgcg tctggcgatc tgaagcccgg acgagaggca aatgtggtca tgagtcgcgg
1377541 gcggataccg aggctgggcg ctgccgtact ggtggcgttg acgaccgcgg cggcggcgtg
1377601 cggggccgat agccaggggc tggtggtcag cttctacaca ccggccaccg acggcgcgac
1377661 gttcaccgca attgcccaac gctgcaacca acagttcggc ggccggttca ccattgcgca
1377721 ggtcagcttg cccaggtccc ccaatgagca acggttacag ctggcccgac ggttgaccgg
1377781 taacgaccgc accctggacg tcatggcgct ggatgtggtg tggacggcgg agttcgccga
1377841 agcggggtgg gcgctgccgc tgtcggacga cccagcgggg ctggccgaga acgacgccgt
1377901 cgccgatacc ctgccaggcc cgcttgcgac ggccggctgg aaccacaagc tgtacgcggc
1377961 acccgtcacc actaatactc aattgctttg gtaccgacca gatttggtaa atagcccgcc
1378021 aacggattgg aatgccatga tcgctgaggc ggcccggctg cacgcggcgg gcgagcctag
1378081 ctggatcgcg gtacaggcca atcagggcga gggcttagtg gtgtggttca acacgctgct
1378141 ggtgagcgct ggtggatcgg tgctctccga ggacggccgg cacgtcacct tgaccgatac
1378201 tcccgcacac cgagcggcta cggtcagcgc gctacagatc ctcaaatcgg tggctaccac
1378261 gcccggcgcc gacccctcga tcacccgcac cgaagagggc agcgcgcggt tggccttcga
1378321 acagggcaag gccgcgctcg aggtcaattg gccgttcgtg tttgcgtcca tgctcgagaa
1378381 cgcggtgaag ggtggtgtgc ccttcttacc gcttaaccgg attccgcagt tggccggcag
1378441 catcaacgac atcgggacgt tcacgcccag cgacgagcag ttccgcatcg cgtatgacgc
1378501 cagccagcag gtgttcggtt tcgcgcccta tccggctgta gcgcccggcc agccagccaa
1378561 ggtgacgatc ggcgggttga acctggcggt ggccaagacg acccgccatc gagcggaggc
1378621 attcgaagcg gtgcgttgtc tgcgtgacca gcacaatcag aggtacgtct cgctcgaggg
1378681 gggtctgccc gcggtgcggg cgtcgctgta ctccgatccg caattccagg cgaagtatcc
1378741 gatgcacgcc attattcggc agcaactcac cgatgccgcg gtgcggccgg cgacgccggt
1378801 gtaccaggcg ttgtccatcc ggctcgcggc ggtgctgagc ccgatcaccg agatcgaccc
1378861 ggagtccacg gccgacgaac ttgccgcgca ggcgcagaaa gccatcgacg gcatgggcct
1378921 gctcccgtga cctccgttga acagcggacc gccaccgcgg tcttttcccg taccgggagc
1378981 cgcatggccg aacggcgact ggcgttcatg ctggtcgcac ccgccgcgat gttgatggtg
1379041 gcggtgacgg cctatcccat cggttacgcg ctgtggctta gcctgcagcg caacaacctg
1379101 gccaccccga acgacaccgc gttcatcggg ctgggcaact atcacacgat cctgatcgac
1379161 cggtattggt ggacggcgct ggcggtgacg ctggcgatca cggcggtttc ggtgacgatc
1379221 gaattcgtct tggggttagc gctcgccctg gtaatgcacc gcacgctgat cggcaagggg
1379281 ttggtgcgca ccgcggtgct cattccgtac ggcatcgtca cggtggtcgc ctcgtatagc
1379341 tggtactacg cctggacgcc gggcaccggg tatctggcca acctgctgcc gtatgacagt
1379401 gcgccactga cgcaacagat cccgtcgttg ggcatcgtgg tgatcgccga ggtctggaag
1379461 acgacgccgt ttatgtcgct gctgcttttg gccgggttgg cgctggtccc cgaggatctg
1379521 ctaagagcag cgcaggttga cggcgccagc gcctggcggc ggttgacgaa ggtcatcttg
1379581 ccgatgatca agccggcgat cgtggttgct ctgctcttca ggaccctgga cgctttccgg
1379641 attttcgaca acatctatgt gctgaccggc ggcagcaaca acaccggatc ggtgtcgatc
1379701 ttgggctacg acaacctgtt caaggggttc aacgtgggcc ttggttcggc gatcagcgtg
1379761 ctgatctttg gctgcgtggc cgtcattgcg ttcattttca tcaagttgtt cggcgccgcg
1379821 gcgcccgggg gtgagccaag tgggcgttga acgggtgggc gcgcggcgcg ccacgtattg
1379881 ggccgtcctg gacactttgg tcgtggggta cgcgttgctc ccggtgctgt ggattttcag
1379941 cctgtcactc aagccgacgt caacggtcaa ggacggcaag ctgattccgt cgacggtgac
1380001 tttcgacaac tatcgtggca tcttccgggg cgacttgttc agctcagcgc tgatcaactc
1380061 catcggaatc ggcctgatca ccaccgtgat cgcggtggtg ctcggcgcga tggcggccta
1380121 cgcggttgcc cggctggaat ttccgggcaa gcggctgcta atcggggctg ccttgctgat
1380181 cacgatgttc ccgtcgatct ctttggtcac accattgttc aacatcgaac gtgccatcgg
1380241 cctgttcgac acctggccgg ggttgatctt gccgtacatc accttcgcgt tgccgctcgc
1380301 gatctacacc ctgtcggcgt tcttccggga gatcccttgg gatctggaaa aggcggccaa
1380361 gatggacggt gcaacgcccg gtcaggcttt ccggaaggtg atcgtaccgc tggcggcgcc
1380421 gggcttggtg accgctgcaa tcctggtgtt cattttcgcc tggaacgatc tgctgctcgc
1380481 gttgtcgctg accgctacca aggcggcgat taccgcgccg gtggccatcg ccaacttcac
1380541 cggcagttcg caattcgagg agccgaccgg ctcgatcgcg gccggcgcga tcgtgattac
1380601 gatcccgatc atcgtctttg ttttaatctt ccaacgacgg attgtcgccg ggttgacctc
1380661 tggcgctgtg aagggatagc gcgatggccg agattgtgtt ggaccacgtc aacaagagtt
1380721 accccgacgg tcacacagcg gtgcgcgacc tcaacctcac catcgccgac ggcgaatttc
1380781 tgatcctggt agggccttcc ggttgtggca agaccacgac gctgaatatg attgctgggc
1380841 ttgaagatat ctcgtcggga gaactgcgca tcgccggtga gcgggtaaac gagaaggcgc
1380901 caaaggaccg tgacatcgcg atggtgttcc agtcgtacgc gctttacccg catatgacgg
1380961 tgcgccagaa catcgcgttc ccgctgaccc tggcgaagat gagaaaggcc gacatcgcgc
1381021 agaaggtctc cgagactgca aaaatccttg acctgaccaa ccttctggat cgcaagccct
1381081 cacaattgtc gggtggtcag cgacagcggg tcgcgatggg cagggcaatc gtgcgccatc
1381141 ccaaagcatt cctgatggac gagccgctgt cgaacttgga cgcgaagttg cgggtccaga
1381201 tgcgcggcga gattgcccag ctgcagcgga ggctgggtac caccaccgtc tacgtcaccc
1381261 acgaccagac cgaggcaatg acgctgggcg atcgcgtggt agtgatgtac gggggcatcg
1381321 cacagcagat cggcacccct gaggagcttt acgaacggcc cgccaatctg tttgtcgcgg
1381381 gctttatcgg ctcgccggcc atgaatttct tccctgccag gctgaccgcg atcggactga
1381441 ccctgccgtt cggtgaggtg acgctggccc ccgaagtcca gggggtgatc gcagcgcacc
1381501 cgaaaccgga aaacgtcatc gtaggcgtgc ggccggagca tatccaggac gcagcattga
1381561 tcgacgcgta tcaacgcatc agggcgctga ccttccaggt gaaggtcaac ttggtcgagt
1381621 ctttaggcgc cgacaaatat ctgtatttca ctaccgagag cccggctgtg cactcggttc
1381681 agttggacga gttggcggag gtagaggggg agtcggcgtt acacgaaaat cagttcgtgg
1381741 caagggttcc cgccgagtcc aaggtagcca tcgggcagtc ggtcgagttg gctttcgata
1381801 ccgccagact tgccgtcttc gacgccgact ccggtgcgaa cctgaccatt ccgcaccgcg
1381861 cctaatggcg gcgagcggac acataagccc ccgccacgcc gaaggatttg gagctttttg
1381921 cgtctgttcg ccgacgcgaa gctagagcca gtttctgttg cggaagacgt ggtagaggaa
1381981 cagacagata aggaccatcc cgccgatcac tgtcgggtaa ccccacctgg agtccagctc
1382041 gggcatgaag tgaaagttca tgccatagat gcccgcgatc atggtgggga ccgcgatgat
1382101 acctgcccac gcggatatct tgcgcatgtc catgttttgc tgcatgccga cccgggcgag
1382161 cgcggcctgc accagcgagt tgagcatgtc gtcgtagctg gcgatctggt cggcggcctc
1382221 ggtctggtgg tcggcgacgt cgcgcaggta gcgccgcact tctttcgaaa tgaggtcttt
1382281 gctctcggtc tgcatgcgct ggaatgcggt cgatagcgga ttcacgcacc ggcgcaactc
1382341 gaccacttcc cgcttgagca gatagatcgg ttcgatgtcg agcttgcggc ccggcgcgaa
1382401 cgctacttcc tcgatgctgt cgatatcggt ctccatgaga ttggtcacct cgaggtagtg
1382461 gtcgaccacg tagtcggcga tcgcgtgcat caccgcatac ggtcccaacc gcaaatgttc
1382521 ggggtcggca tccatccgct tacgcacctc ggataacccg ccgtgttcgc cgtggcggac
1382581 ggtgaccacg aaatccttgc cgacgaagat catgatctcg ccggttttga cgatctcgcg
1382641 ggccagtacc accgattcgt gcgggacgta gttgacggtc ttgaggacga ggaacagcgt
1382701 ctcgtcgtag cgctccaact tgggtcgctg gtgcgcgtgc acggcgtcct caacggctaa
1382761 cgggtgcaac ccgaaaacgt ctgctacgtc ctgcatctgg ttttcatcgg gctcgtgcag
1382821 cccgatccag acgaacgcct cctgcccggt cagttcgatc tcgcgcacct cgcgcagcgc
1382881 ggcggcgtag gtgtacttgc cgggcagtcg ctggccgcag acgtagacac cgcagtcgac
1382941 caaggcttgg gccggtggct gggcaacggg gtgtgcgttc ggcggctggg gtcgcgcgac
1383001 cggtcgcagc acttcgggca atgcgtcaaa ccctgggaac acgtcaacct ccgatcgcgg
1383061 tggatctgat cgggcggtgc tccaggttac gcgtcccggt atggaacttg gtaaacgtca
1383121 gtcgtagctg tgggggttgg accccagatg tccgtccggt gccggtgcgc tagtttcaac
1383181 ccgaagccaa gtccgtaagg agcagaaccg acgtgagcgc tagtcctctc aaggtcgccg
1383241 ttaccggcgc cgccggccaa atcggctaca gcctgttgtt ccgcctggcc agcggctctt
1383301 tgctgggccc tgaccgtccg atcgagctgc ggctgctcga gatcgagccg gcactgcagg
1383361 cgctcgaggg tgtggtgatg gaactcgacg actgcgcttt cccgctgttg tccggggtgg
1383421 agatcggttc cgatccccag aagatcttcg atggtgtgag cctggccctg ctggtcggag
1383481 cccgcccccg gggcgcgggc atggagcgaa gtgacctgct ggaggccaac ggcgcgatct
1383541 tcaccgctca gggcaaagcc ctcaacgctg tcgccgcgga tgacgttcgc gtcggggtga
1383601 ccggcaaccc cgccaacacc aacgcgctga tcgcgatgac caatgcgccc gacattcccc
1383661 gcgagcggtt ctcggcgctc acccggctgg accacaatcg ggcgatctcg cagctggccg
1383721 ccaagaccgg cgcggcggtc accgacatca agaagatgac gatctggggc aatcactcgg
1383781 ccacccagta ccccgacctg ttccacgcgg aggtcgccgg aaagaacgcg gccgaagtgg
1383841 tcaacgacca ggcctggatc gaggatgaat tcatcccgac ggtcgccaag cgcggtgcgg
1383901 cgatcatcga tgcgcgcggc gcgtcgtcgg ccgcctcggc cgcgtcggca accatcgacg
1383961 ctgcccggga ctggttgctg gggacgccgg cggacgattg ggtctcgatg gccgtcgtct
1384021 ccgacgggtc ctacggggtg ccggagggct tgatctcctc gtttccggtc accaccaagg
1384081 gcggcaactg gacgatcgtg agcggcttgg agatcgacga gttctcccgc ggccggatcg
1384141 acaagtcaac cgccgagttg gctgacgagc gcagcgcggt caccgagctc ggcctgatct
1384201 gagcgcaggt cagccgcgca ctgagcggag cccgagtcat cttgacgtgt gtttgtccag
1384261 gcatcatgat gacctgtatg cgcaccacct tgacgctcga tgacgacgtc gtccggctgg
1384321 tcgaagacgc agtgcatcgc gaacgccgcc cgatgaagca ggtcatcaac gatgcgctgc
1384381 gcagagcgct ggcgccgccg gtgaaacggc aggagcagta tcggttggag ccgcatgagt
1384441 cggctgtgcg ttccgggttg gatctggccg gcttcaacaa gttggccgac gaactggagg
1384501 atgaggcgct gctggatgcc acgcgtcggg cccggtgatc atccctgaca tcaatctgct
1384561 gctctacgcg gtcatcaccg gattcccgca gcaccggcgc gcgcatgcgt ggtggcaaga
1384621 caccgtcaac ggccacaccc gtatcgggct gacgtatccg gcgttgttcg ggttcctacg
1384681 gatcgccacc agtgcccgcg tgctcgccgc gccactgcca accgcggatg cgatcgccta
1384741 tgtgcgcgag tggctttcgc agccgaacgt ggacctactc acggcgggtc cgcgccacct
1384801 ggacatcgcg ttgggcctgc tcgacaagct cggcacagcc agccacctaa ccaccgatgt
1384861 gcaactggcc gcctacggca tcgaatacga cgccgagatc cattccagtg acaccgactt
1384921 tgcccgattc gccgatctga agtggaccga cccgttgcgc gaataatgac tgccgctctg
1384981 ccctcgggtc agccgttcag gccgtgctga ccgttggcgc cggtagcgcc ttgagtaccg
1385041 ggatcgccgg gggcgccggg gttgaacccg gtcccgccgc cgccgcccgc gccgccgttg
1385101 ccgcccgcgc cgccgaggcc cccggccgcg ccggagccgg ggctgcccga ctgtccgaac
1385161 agtccgcccg caccgccggt cccgccgttt ccgccgacgc caccggcccc gccggccccg
1385221 ccgtcgccgc cgttgccgcc gtcaccgccg tcgccgtcct ggttggccat gccgtcggcg
1385281 ccgatcccgc cgttgccgcc gttgccgccg ctgccgcctt gagcgccgat gcccccgtcg
1385341 cccccgacgc cgccgtcgcc gccggcgccg cccgtgccga gcagtagccc gccgcgaccc
1385401 ccgctgcccc caaagccgcc ggcgccacca acgtcagccg aggcaccgac gccgccgtcg
1385461 ccgccggcac caccattgcc cccggtggag ttgcccccag gaggattatc ttgattggca
1385521 tttcctccgg cgccgccggc accaccggga gcgccgatac cgccgttccc gccggcgcca
1385581 ccgttgcccc ctatgctgtt gccagcattt gcaacattgg cgctgccacc cgctccgccc
1385641 agccccccgc cgccgccggc tccgccgttt ccgccggcgc cgccattgcc gccgacagcg
1385701 tcaccaaagc cgctttgagc ggcgccaccg ttaccgccgg cacctccgga ggcgaagttg
1385761 gcgccgtcgc cgccgtcgcc gccggcaccc ccggacacgt cggtctgccc aaggttggtt
1385821 ccatccccgc ctatgccgcc tgcaccaccg cccacgccgg ggttgactgc gttgctgccc
1385881 gagccggcgt cggtcccgtt gccatcgggt ccggtagtgc cgtcggcgcc atcggtcgcg
1385941 tgcgtgacct gatgggacac cgggttttgc ccgttggcgc cggccgctcc tgccgctccg
1386001 gctccacccg cccccccgtt gccccatagc ccggcgttgc cgccgtggcc tccgttgccg
1386061 ccattgcccc cgatctgggt ggccgcccca ccgttgccgc cgagcccacc gttgccgtat
1386121 agccacccgc cgttgccgcc ggcaccgccg ttcgcgccgg gcccgccggc tcccccggcg
1386181 ccaccgttgc cgatcaaccc ggccgcgccg ccgcgaccgc cgggctggcc tggggtgcta
1386241 ctcgagccgc cgttgccgcc gttgccgtac aacaagccac cgtcgccccc gttttgtccc
1386301 ggcccgccgt tggcgccatc gccgatcagc gggcgcccca gcaacagctg ggtgggccca
1386361 ttgaccacat ccagcaccgc ttgcatcggg gaggcattgg cggcctcggc cgccgcatac
1386421 gagccggccg ccgaactcag tgcccgcaca aactgctgat gaaatgccgc cgcctgtgcg
1386481 ctcagcgctt gataggcctg ggcgttcccg gaaaacagcg acgcgatggc cgctgatacc
1386541 tcgtcggcac ccgcggccag cagccccgtg gtcggggcct cggccgccct gttagctgcg
1386601 gccagcgccg agccgatgcc ctccaaatca gcggccgcgg ccaccaacac gtcctgcgct
1386661 gcaatcagat actccatcgc ggggcctctc tcgcggcgag attgaccaac gggtcggcac
1386721 gaagcgtgtc ccgttgcttg acggtgcatt gcgtgtttgc ctggatcccc gcgccgacgg
1386781 tgtggatcgg gcccagtacc ctcaagcccg tgccaactgc atctgtcgcg gtgactatcg
1386841 gctcagacac ttcggtgtga gaatcaccag gatcctcgcg ctgctgcttg ccgtcctgct
1386901 tgcagtgtct ggcgtggctg gctgctcggc cgacaccggc gatcgccacc cggagttggt
1386961 ggtcggatcc acgccggact ccgaggcgat gctgctggcc gccatctacg tcgcggcgct
1387021 gcggtcgtac ggttttgcgg cgcacgccga aaccgccgcc gacccggtgg cgaaactgga
1387081 ctcgggcgcg ttcaccgtcg tacccgcttt caccggtcag atgttgcaga ccttgcaacc
1387141 cgatgcgtcg gtgcgctcgg atgcccaggt ataccgcgcc atcgtctcgg cccttcccga
1387201 gggcatagcc gcaggcgact acaccaccgc cgcagaagac aaacccgcgt tggtggtgac
1387261 tcaatccacc gccaaggcct ggggcggcgg cgatctcagc gagctgccca gccactgccg
1387321 cgggttgttg gtcgggcgcg ttgccggcgc ccacacaccc gcggccgtgg gaccgtgccg
1387381 gctgcccgcc ccgcgtgagt ttcggaatga cgcaacaatg ttcgccgcgc tgcgggccgg
1387441 acagctggtc gcggcctgga ccaccaccgc cgaccccgac atccccgcgg acctgatcat
1387501 gctgaccgac ggcaagcccg cgctgatccg ggccgagaac atcgttccgc tgtatcgtcg
1387561 caacgcgctg accgagcggc aactgctggc cgtcaacgag gtcgccggcg tgctggacac
1387621 cacggccctg atcgggatgc gccgccaggt ggccgcgggg gccgacccgg cggcggtggc
1387681 cgccggctgg ctcgccgaac acccgctggg acgttgagcc gccacgagcg tccgggtcga
1387741 cgcgatgaca caccgcgtcg gccgaacaac cttcgggcgc gctttcctca ccagccgtca
1387801 gcgcgggcgg ggtatcaacc ggccggtgat gatcggaaag atccgctgat atccggaacc
1387861 ggtcagccgg accaccaggt ccagtacctt ggcgtcgaca cccaccaaca cccgggcctt
1387921 gttcttggcc acccccgtca ggatgatctg cgcggcccgc tgtgggctga gatgggccac
1387981 ccgcttatcg aacgtctcgg ccagctcggc ctggtcaagt ccctcggcgg cggtggcgtt
1388041 acgggcgatc gcggtcttga caccgccggg gtgcaccgtc gtcaccttca ccgggtgacc
1388101 cgccaacgcc atttcctggc gcagcgcctc ggtaaagccg cggacggcga acttggccga
1388161 gttgtaggcc gcctgacccg gcgccgaaaa caacccgaac acgctggaga tgttgatgac
1388221 gtggccgtcc ccggaggcga tcaaatgcgg caggaacgcc ttggtgccgt tgaccacacc
1388281 ccaaaaatcg acgtccatca cccgttcgat gtccttgaac tggctgacct cgatatcgcc
1388341 ggtaaaggcg atgccggcgt tgttgtagat ctggttcaca gtgccgaagt gctcgttgac
1388401 cgcatcggcg taggctagga aggcttcgcg ttcggttacg tcgagtcggt ccgtcttgac
1388461 cggcgtgctg atcgccttta gccggtgctc ggtgtctgcc aggccgtcgg tgtcgacgtc
1388521 gctgatggcc accttggcgc ccgagcgggc cagctcgatt gccagcgcct gcccgatgcc
1388581 cgatcccgcg ccggtgacaa cggcgacctt tccggcgaac ccctccatga cgtaccctcc
1388641 cttgtctcgg ctgccatcag gttagccggt acccggggta cggcttaacg tggccggcac
1388701 gggttcattc ggtagctggc actgcgacga gcgatgtgga tgatctcgac tcggtggtgg
1388761 ccgtcgtcga tggcgtagac gacgcggtaa tcaccgcggc gggctgagtg gaggccttca
1388821 aggtcattgc gcagcggctt gcccaaccta tgcgggttgt taagcagcgg tccgaaaaca
1388881 aactcgacac atgcggcggc gatcttttcg ggtaagcgtt gcaggtcgcg tgccgctgtc
1388941 gcggtgatcg ccacgtggta gggatggtcg tcgctcaccg cgcggtgtaa cggttgcgga
1389001 tctcgtcgtt gctcacgaag cgccctgcgg caacatcggc gaggccttca cgaatggcct
1389061 cgctggcgcc aggggtgcgt agcacctcca gcgtttcctc gatggacgcc aggtcatcgg
1389121 ccgagatcaa taccgccgcc ggatgaccgt gccgggttat cgtgatgcgc tcgtgtgtca
1389181 gctcaacttc ggcgacgtac tcagagaggc gattgcggac ttcgcccagt gggacaacag
1389241 ccataaccgc gattgtagct aaaagtatgg ctaaaccctg tacgccgagc atcggcttac
1389301 cgagccgaac gcctcgtcgc tgtttgatgt ctcctcgagc gttcggctga gcgaactcag
1389361 ccgaacgcct cgtcgaggat ctcctgctgt tcgacggcgt gcaccttcga cgagcctgac
1389421 gacggggctg acatcgcccg gcgcgagatt cgcttgatcc cggccaactt gtcaggcagc
1389481 agctcgggta gttcgagccc gaatcgcggc cacgcaccct ggttggccgg ttcctcttgg
1389541 acccagaaga actccttgac gttctcgtag cggtccagcg tttcacgcag tcgacgcctg
1389601 ggcagcgggg cgagctgttc aagccgcacg atcgcgaggt cattgcggtt gtccttggcc
1389661 ttgcgggcgg ccagctcgta atacagcttg ccactggtca gcaggatccg gctgaccttg
1389721 ttgcggtctc cgatgccgtc ctcataggtg ggttcctcca gcactgagcg gaacttgatc
1389781 tcggtgaagt ccttgatttc gctgacggcg gccttgtgac gcaacatcga cttgggcgtg
1389841 aacacgatca gcgggcgttg gatgccgtcc agggcatgcc ggcgtagcag gtggaagtag
1389901 ttcgacggag tcgacggcat cgcgatggtc atcgaacctt ccgcccacaa ctgcaagaag
1389961 cgttcgatcc gggcagaagt gtggtcgggt ccctgcccct cgtgcccgtg cggtaacagc
1390021 agcacgacgt tggacaattg gccccacttg gcctcaccgg agctgatgaa ctcgtcgatg
1390081 atcgactgcg cgccgttgac gaagtcgccg aactgcgcct cccagagcac cacggcgtcc
1390141 ggattgccca cagtgtagcc gtactcgaag ccgacggcgg cgtactccga cagtggcgag
1390201 tcgtagacca ggaactttcc gccggtcggg ctgccgtcgg agttggtcgc cagcagctgc
1390261 agtggtgtga actcctcgcc agtgtggcgg tcgatgagaa ccgaatgccg ctgggagaag
1390321 gtgccgcggc ggctgtcctg ccccgacaag cgcaccagct tgccttcggc caccagcgag
1390381 cccagcgcca gcagctcgcc aaaggcccag tcgatcttgc cttcataggc catctcccgg
1390441 cgcttctcca gcaccggttg gactcgcggg tgcgcggtga agccgttcgg caaggcgagg
1390501 aacgcatcgc cgatccgggc cagcagcgac ttgtccaccg cagtggccag ccccgcggga
1390561 atcatctggt cggactcgac cgactcgctc ggctgcacac cgtgcttctc cagctcgcgc
1390621 acttcgttga acacccgttc cagctggccc tggtagtcgc gcagcgcgtc ctcggcctcc
1390681 ttcatcgaga tgtcgccacg tccgatcagg gcttcggtgt agcttttgcg ggccccgcgc
1390741 ttggtgtcga cgacgtcgta cacgtagggg ttggtcatcg acgggtcgtc accctcgttg
1390801 tgcccgcggc ggcggtagca cagcatgtcg atgacgacgt ccttcttgaa ccgttgtcgg
1390861 aagtccaccg ccaaccgcgc cacccagaca cacgcctccg ggtcgtcgcc gttgacgtga
1390921 aagatcggtg ccccgatcat ctttgcgacg tcggtgcagt actcgctgga cctggaatac
1390981 tcgggcgcgg tggtgaagcc gatctggttg ttgacgatga tgtggatggt gccgccgacg
1391041 cggtagcccg gcagattcgc caggttcagc gtctcggcga ccacaccctg accggcgaac
1391101 gcggcatcgc catgcaacat cagcggcacc accgagaacg cccgttggcc gtcgctgtcg
1391161 atgcttccgt ggtcgagcag atcctgcttg gcccgcacca atccctccag caccgggtcg
1391221 acggcctcca gatgcgacgg gttggcggtc agcgacacct gaatgtcgtt gtcgccgaac
1391281 atctgcaggt acagcccggt ggcgcccagg tggtacttga cgtcaccgga gccgtgcgcc
1391341 tgcgacggat tcaggttgcc ctcgaactcg gtgaagatct gcgagtacgg cttgccgacg
1391401 atgttggcca gcacgttgag ccggccccgg tgcggcatcc cgatgaccac ctcgtcgagg
1391461 ccgtgctcag cgcactggtc gatcgccgcg tccatcatcg ggatcacgct ttcggcgcct
1391521 tccagcgaga accgcttctg gccgacgtac ttggtctgta ggaacgtttc aaaggcctcg
1391581 gcggcgttga gcttgctgag gatgtatttc tgttgggcca cagtgggttt gacgtgcttg
1391641 gtctcgaccc gttgttcgag ccactccttt tgttcggggt cgaggatatg ggcgtactcc
1391701 acgccgatgt ggcggcagta ggcatcgcgc agcaagccca gcacgtcgcg cagtttcttg
1391761 tactgcgcac cggcaaagcc gtcgaccttg aacacccgat cgagatccca cagcgtcagg
1391821 ccgtgggtca gcacttcgag gtcggggtga ctgcggaacc gagctttgtc caaccgcagc
1391881 gggtcggtat cggccatcag atggccgcgg ttgcggtagg ccgcgatcaa gttcatgacg
1391941 cgagcgttct tgtcgacgat cgagtcgggg ttgtcggtgc tccagcgcac cggcagatat
1392001 gggatgctca gttcgcggaa gacctcgtcc cagaagccat ccgagagcag caactcgtgg
1392061 atggtgcgca ggaagtcgcc cgattccgcg ccctggatga tgcggtggtc gtaggtggag
1392121 gtcaaagtga tcaatttgcc gatgcccagc tcggcgatgc gttcctcgct ggcgccttga
1392181 aactcggcgg ggtattccat ggcgcccacg ccgatgatgg cgccctggcc gggcatcagc
1392241 cgcggcaccg aatgcacggt gccgatggtt ccgggattgg tcagcgaaat cgtcacgccg
1392301 gcaaagtctt cagtggtcag cttgccgtcg cgggcccggc gtacgatgtc ttcgtaggcc
1392361 gtgacgaact gcgcgaatcg catggtctcg caccgcttga tgccggccac caccagggaa
1392421 cgcttcccgt ccttgccttg caggtcgatc gccaggccga gattggtgtg cgccggcgtg
1392481 accgcggtgg gcttgccgtc gacttcggtg tagtgccggt tcatgttcgg gaatttcttc
1392541 accgcctgca ccagggcgta gcccagcaaa tgcgtgaacg agatcttgcc gccgcgggtc
1392601 cgcttcaact ggttgttgat gacgatccgg ttgtcgatca gtagcttggc cgggaccgcc
1392661 cggacgctgg tcgccgtcgg cacctccaac gacgcggaca tgttcttgac gacggccgcg
1392721 gcggcgccgc gcagcaccgc tacctcgtca ccttcggctg gcgggggaac ggcagttttg
1392781 gcggccagtg cggcgaccac gccgttgccc gcggccgcgg tgtcggccgg cttggggggt
1392841 gcctgcgggg cggccgcagc ggcccgctcg gcaacgagtg gcgaggtaac ccgggttggt
1392901 tcggcagctg gttgggaggt gggttcgggg ctgtagtcaa ccaggaactc gtgccagctg
1392961 ggatcgaccg aggaggggtc gtcgcggaac ttgcggtaca tctcttcgac cagccattcg
1393021 ttttgcccga atggtgaact tatgttggcc acggccgctg ttcgcctcga ttcttctgct
1393081 agttgaagtc ctgcaagcgc attgcgcggc gcctgctggc agtcggtgaa cggtctgccc
1393141 cataaaggct aacgctttgc cagcgattcg ccagagagac cgggcaacgc gcgctagctg
1393201 gcatcccgaa cggtcggtag cacgtgcagg gtgaccggcc agcgcgccgg cggggtgccg
1393261 aatgccgatc gcgcattacg gacgagcttc ttgccgacca gccgattgcc gatggcgccg
1393321 atgatcgcgc cgatacccat cggcaccagc ttgccaaaca tgagcgcgcc gcgtttcagc
1393381 gcgaatcgtt tgacgacgta tttgagcatt cgcgagttca acgacgatat cgccggcagc
1393441 ggcagcgagg ccatggtctc cgacacccag ccgccgctgg ttcggcccgg accgagcaga
1393501 tcggccaccg cagtagtgtt gtcgccgacc agcaccgcca agaccagggc acggcgccgt
1393561 tctcggtggt cgaggggaat ggcgtgtacc gaggccagcg ccagcacgaa cagcgcggtg
1393621 gcctcaagga acacgacaac ctctccggcc gcggcgaacc atgcggccag ggtgccgatc
1393681 cccggtaagg tcgcggccgc acctaccgcc gctccactgg ccgtcaccac cgacaagaag
1393741 cgtttctcga gcttggctac gatcttggcg gggctggccc ccgggtgggc gcgacgcagg
1393801 cgggccacat acgcctgtgc tgccgggccc tgtatccgcg aactccgttc gatgacctgc
1393861 gccaatgccc gcgtggacac tttgggccgc ccgccggtcc cggccagctg cgggtccggc
1393921 tcagctgcat ttgcggatcg attgtcgaac cttttccaag acctgattcg tcgagcgctc
1393981 atcttctctc ctgcgaatgg cgtcccctca ggctaatgcc ggttcaacga tccgagcatg
1394041 tgtttcggta gcggcgcggt tcaccgctcg aagcggaata atgcggcgtg gacattggtg
1394101 acgatacggg ttgccctggt gcatgccgtg acgcccgtga cccaatgcca ccgctagcaa
1394161 gccaaacgag gtgcgtgtat gactacggcg atacgccggg cggccgggag cagctacttc
1394221 cgaaacccct ggcctgcgct gtgggcgatg atggttggct tcttcatgat catgctcgac
1394281 tccaccgtcg tagccatcgc gaatccgacc atcatggccc agctacgcat cggttacgcc
1394341 accgtggttt gggtgaccag cgcctatctg ctggcctacg cggtgccaat gctggtggcc
1394401 ggccggcttg gcgaccggtt cggcccgaag aatctctacc tgattggcct gggggtattc
1394461 accgttgcgt cgctggggtg cggtctgtcg agcggtgccg gcatgctgat tgccgctcga
1394521 gtggtgcaag gcgtcggcgc cggattgctt accccgcaga cgctgtcgac gataacgcgg
1394581 atcttcccgg ctcatcgccg cggtgtcgcg ctgggcgcat ggggcaccgt cgccagtgtc
1394641 gccagcctgg tgggaccgtt ggccggcggc gcgctggtcg acagcatggg gtgggagtgg
1394701 attttcttcg tcaacgttcc cgtcggcgtc atcggcctga tcctggcggc ctatctgatt
1394761 ccggcactac cccaccaccc gcatcggttc gattggttcg gcgtcggatt gtctggtgcg
1394821 ggaatgtttc tgattgtctt cggactacag cagggccagt ccgccaattg gcagccttgg
1394881 atttgggcgg tgatcgtcgg cggtatcggg tttatgtcgc tgttcgttta ctggcaggcg
1394941 cggaacgccc gcgagccgct gatcccactg gaggtcttca acgaccggaa cttcagcttg
1395001 tccaacctca ggatagcgat catcgccttc gcggggacgg ggatgatgct gccggtgacg
1395061 ttttatgcgc aggcggtgtg tgggttgtcg ccgacccaca cggccgtgct gttcgcgccg
1395121 acggcgatcg tcggtggcgt gctggccccg ttcgtcggca tgatcattga caggtcccat
1395181 ccgttgtgcg tactgggttt cggcttctcg gtgctggcga tcgcaatgac atggctctta
1395241 tgcgagatgg ctccgggcac gcccatctgg cggctggtgt tgccgttcat cgcgttaggc
1395301 gttgctgggg cgttcgtgtg gtcgccgctg accgtcaccg cgacccgcaa tctacggccg
1395361 cacctggccg gtgcgagctc aggtgtgttc aacgccgtcc ggcagctggg ggctgtgctg
1395421 gggagcgcga gcatggccgc gttcatgacg tcgcgcatcg ccgccgagat gcccggtggt
1395481 gtggacgccc ttaccggtcc cgccgggcag gacgctaccg tgttgcagct gcccgagttc
1395541 gtgcgcgaac ccttcgcggc cgcgatgtcg caatcgatgc tgttgcccgc cttcgtcgcc
1395601 ctattcggga tcgttgccgc gttgttcctg gttgacttca ccggtgctgc ggttgccaaa
1395661 gagccgttgc ccgaatccga tggcgacgct gacgacgacg actatgtcga gtacatcctt
1395721 cgtcgggaac cggaagagga ttgcgacacc cagccgctgc gggcgtcgcg cccggcagcg
1395781 gccgcagcgt cacgcagcgg tgctgggggt ccgctggcgg tcagctggtc gacgtcagcc
1395841 caaggaatgc ccccaggtcc accaggccgt cgggcgtggc aggcagatac tgagtcaaca
1395901 gctccgagcg cactataacc gcggcatact gtgcccgact gaccgcgacg ttgagccgat
1395961 tccggttgag caggaacgag attccgcgtg gaacatcgtc ggcggacgag gccgtcatcg
1396021 agatgaagac caccggtgcc tgcccgccct ggaatttgtc gacggtgcct acccgtactc
1396081 cgtcagcccc gccaagtccg gcagacgcca accgccgacg gaccagcgcc acctgggcgt
1396141 tgtacggcgc gagcacaagc acatcggaag cggccagtgg ccgggtgccg tgctcgtcgg
1396201 tccacggcga gccgagcagc tgccgcagct cggcgaggat cgcctcggcc tcttcggggc
1396261 tttcgatcga attgcccttg tggtgcacgc cacgcgtatg cacccccggg ggatacccgt
1396321 cgaggcggcg cacggcggtg cgctcggtgt gggaacacag cctgccctcg taggacaacg
1396381 ccgacacggc cgcgcacacc gccgggtgca tccggtacga gcggtctaag aagtagccgc
1396441 gttcgtcggg cagcgtgtgt tgcccatcta ccagccacga caatgcggag gtgtcgacgg
1396501 gttcgggatg tgtgccctga cttacctgag gcagttgctg tggatcgcca agcagcaaca
1396561 ggtttgtggc cgcgggcgcc acggcgatgg tattggccag gcagaactgg ccagcctcgt
1396621 cgatcaccag cagatccagg ctggctttcg gcacccgatt gccgttggcg aagtcccacg
1396681 ccgtgccgcc gatcacgcat ccggcggtgt cgcggatgaa ttctgtgtac tggctcccgt
1396741 cgatcgactg ccagcgccca gcggtgtggt cgtgcggctt tttggcgacc tgccccgggt
1396801 ccaggccagc gctgatcaca ccttccaaca ggttctccac cgtggcgtgc gactgggcga
1396861 caacgccaat acgccaggca tgctcggtga ccaactccgc gatcacccgg gccgcggtgt
1396921 atgtcttgcc ggtccccgga gggccgtgca ccgccaggta tgacgagtcc aagtccagcg
1396981 ccgccgcggc gatatcggtg actgggtcac tgctgcgggg caatgcggcg ccgctgcgcg
1397041 tgcgaggagg gcgacgcagc agcacgtcca ttagcgcggt gctgggcagt tgcggcgatc
1397101 cggaagccac ggcagcggcc gtcgattcga tcgattcccg cagggccgtc gtcggcaccg
1397161 gcggcccggg agcgagcgcg aacgggagct gctgaaatgt attgccgtca ctgccggttc
1397221 gttcgacgat gaccacctcg gtgggcacag tggggtcgtc ggtctcaacc actgcggcgg
1397281 ggcccgcggc tcggcgatca ggattgtcgg tcatgcccgg cggcgccggg ggttcgtaga
1397341 gggcaaacac attcccgttg aggtccccac gtgccagttc accggtaagc cggacccgcc
1397401 gctgcggctt gcgcgcgcga ggcggcatat gccagtcgac ggtgaccgaa gcctcgctgg
1397461 caaggaagac gtccgtgctg tccgaccatt cgtcgacggg gtagttgagc cggtcgaagt
1397521 gcgcccacca gaacggcttg tcctcgcggc gatgatagcc gcgggcagcg gccagcaagg
1397581 cgaccgctgt ctgttccggc gtgcgctcgc cggcggcggc atcgccggtg aacttggaca
1397641 gtaccgacgc cagcgagtca ccgtcgtcga tagggtcggc gtccggaact ggttgagcgc
1397701 caatgggtgt gacgccggct tcccaggcgc gcatgagcag ccagtcacgc agcgcgcggg
1397761 tggaccggca gtcgtagtgg ttgtagcctt cgatctcttt gagcacggtt gccgcctcat
1397821 cgatgcggcc ggccgcgcgc agttcgcagt accgggcata ggagttgatc gagtcggcgg
1397881 cggtggtgac gtcgccggag cgtggctgcg tcccgaggta cagcggctcc agcgccttca
1397941 agctgaacga gtcggtgccc acccgaatgc tcttgcgtac caacgggtat aagtccacca
1398001 ggactccgtt gcgcagcaag tcgtcgacgt cgtcctcgcc gatgccgtag cgtccgacca
1398061 gccgcagcag cgcggtcttc tcgtagggcg cgtagtggta gatgtgcatg ttggggtggc
1398121 gccggcgccg tctggcgact atcgccagga aatcggtcag cgcctggcgt tcggctgtcc
1398181 ggtcatgcgc ccacaatggt cggaatactc ccgcccgtcc ggcttccagc accccgaaca
1398241 ggtattccag gccccactgt ttgccgtcgg cggtccacag cgggtcaccc tcgaagtcga
1398301 agaacaggtc gccggggttt ggctccggca gcagtgtcag cggccgcggg tcgacgatct
1398361 cgaactgtgg tgctcccgta tcgcgttggc ggatttgcag tttggcctgt gcggtcagct
1398421 tgcccagcgc gttcgtggtc aggccgggaa ccggcgcggt gtgatctgcc agttcggcga
1398481 tcgtggtgat gccggcctca aggagcttgt cgcgctggcg gactcgcatc cctccgacca
1398541 gtagcagatc gtcgctggcg cgcagccgct cggtgcactg cggacagcgg aagcacgcct
1398601 gcacgcgttc gtcgtcccag cgcaccgcgg tgcccgcggt gtagtggccg tccagcaatc
1398661 gctgtaaaag cgcacgctgg gaccggtaga ccgggatgag ctcgccgacg cggtagcgca
1398721 cgatcgtgcc gtcgccgagt tcgagctcgg cgtcggcagc caccggaacg cccgagtgaa
1398781 ccagcgcatc ggcataggcc gccagctgta gcagcgcggt cacggttggc gagcgggcga
1398841 gcttggtgtc ggcgacccgg taccggtgac cgtcgcggat caggaagtcg gcgaacccga
1398901 cgaagcggcc gtcgaacatg gcggcctgat acaccaccgg ggcgtggttg gcgatggcac
1398961 gtcgcgtcgc gtcggcggct gccgccagcc cggcgggcgt gtaggccggc cggccaatga
1399021 tagccaccgc gtcgccgaac tcgtggcgca gttggtcgag tcggcgtcct tcatgcgcgc
1399081 taccgagaac ggcggctcgc gccatcagtt cgtcgtcaac tgcgacggcc ggtccccggc
1399141 ctagtttcgc gtcgaattca cggagcagtg cgtactggca ccgggcggcg gctgcgagat
1399201 ccgaagcact gtagacgatg ctgtcaccgg tgacgaacac agcagcaact cctcggtgag
1399261 acaacggaca ggcaaactgg gctgcacccg tcggcttaac cgccggtggt gttgccgatc
1399321 agctcgacgc cgccgccgtt ccagcggaac ttgacaacgt tgttcaaccc gatgccgctg
1399381 gcatacgtca atgccaccgt gtctcccgtg cactgcgagg tgtcgatgcc ggtgaaccca
1399441 taggtatcgg gcaccccctg cggtatgtac ttgccgaggt ggaacatcac cgcgcgggtg
1399501 gtcggattgc cggcgttcgt gttggccttg atgaccaccg ccgacagctg ggcacactcg
1399561 ttgtagttgc cggccagcgg ttctgggttc cagggctgct cactgcgcgg atcgcgagga
1399621 agttcggaga cgactttggc gattgtgggc gaggcgaggt tcaccgcaca cgggtcgacc
1399681 ggcgcggcgc tgtggttgct gggtggggca gctgtcgcgg acggcgggct cggttcgctg
1399741 ctcggcgggg ccgggtgagc agttgacagg gatggggtgg cctccggcgt cttagcgacc
1399801 gtggagtcgc ccgaaccgca accggtcaac gtcgcggcga ccaatgcagc gaccacgcca
1399861 acacgcggcg tggtggggca gggtggtgac cacacaccgg gcaccgtacc gccatcgggc
1399921 ccgcgggtgc ggtaggcgtg gccgggtcac cactaaactt gacggcctga tggccttccc
1399981 ggaatattcg cctgcggcgt ccgctgcgac gtttgctgac ctgcagattc atccccgcgt
1400041 cttgcgggcg atcggcgacg tcggttacga gtcaccgacg gctatccagg cggctacgat
1400101 cccggcgttg atggcaggct ccgacgtggt ggggctggcg cagaccggca ccggcaagac
1400161 ggcggcattt gcgattccga tgctgtccaa gatcgacatc accagcaagg tgccccaggc
1400221 gctggtgctg gtgcccaccc gggagctggc tctgcaggtg gccgaggcgt tcggccgcta
1400281 cggtgcctat ctgtcgcaac tcaacgtgct gccgatctac ggcggatcgt cgtatgccgt
1400341 gcaactggcc ggattgagac gcggcgcgca ggtggtggtt ggcacccccg gtcgtatgat
1400401 agaccatctc gaacgggcga ccttggacct gtcgcgggtg gactttctag tgctcgatga
1400461 ggccgatgag atgctgacca tgggtttcgc cgacgacgtt gagcgcattc tgtccgagac
1400521 ccccgaatac aagcaggtcg ccctgttttc cgcgaccatg ccgccggcga tccgcaaact
1400581 cagcgccaag tatctgcacg atccgttcga agtcacttgt aaggcgaaaa ccgctgtggc
1400641 cgagaatatt tcgcagagct acattcaggt agcacggaag atggacgcgc tcaccagagt
1400701 gctcgaagtc gagccgttcg aggcgatgat cgtctttgtc cgcaccaagc aggcgaccga
1400761 ggagattgcc gaaaagctgc gtgcccgagg gttttccgcg gctgccatca gcggtgacgt
1400821 cccgcaggcg cagcgggagc ggaccatcac ggcgctgcgg gacggcgaca tcgatatcct
1400881 ggtcgccacc gatgtggcgg cgcgcggact cgacgtggag cggatatcac acgtgcttaa
1400941 ctacgacatc ccgcacgaca ccgagtccta cgtacaccgg atcgggcgca ccggcagggc
1401001 cgggcgttcg ggagccgcgc tgatattcgt ctcgccacgg gagcttcacc tgctcaaggc
1401061 gatcgaaaag gctacgcggc aaacgcttac cgaggcgcaa ttgcccaccg tcgaggatgt
1401121 caacacccag cgggtggcca agttcgccga ttccatcacc aatgcgctgg gcggtccggg
1401181 aatcgagctg ttccgccgac tggtcgagga gtatgaacgc gagcatgatg tcccgatggc
1401241 tgacatcgcc gcggcactgg ccgtgcagtg ccgcggcggt gaggcattcc tgatggcacc
1401301 cgacccgccg ctttcgcggc gcaaccgcga ccagcgtcgg gaccgtccgc aaaggcccaa
1401361 gcgtagaccg gacttgacca cctaccgcgt cgccgtcggc aagcggcaca agatcggtcc
1401421 aggcgccatc gtcggcgcca tcgccaatga gggtgggctg caccgcagcg acttcggtca
1401481 gatccgtatc gggccagact tctcgctagt agaattgccg gcgaagctgc cccgcgcgac
1401541 gctcaaaaag cttgcacaga cccgtatctc gggtgtgctg atcgaccttc ggccataccg
1401601 gccgcccgac gcggcgcgcc ggcataatgg cggcaaacca cggcggaaac acgtcggatg
1401661 accctgccca aggaaagagc cgcccagggc ggactcgagc ggatcgccca cgtggaccgg
1401721 gtggcgtcgt tgaccgggat ccgtgctgtt gccgcattgc tggtcgtcgg cactcatgcg
1401781 gcctacacca ccggcaagta cacccacggc tattggggcc tgatgtcgtc ccgcatggag
1401841 atcggcgttc cgatcttttt cgtgctgtcg gggttcctgc tattccggcc atgggttaag
1401901 tccgccgcta ccggcggccc cccgccgtcg ttgagccgct atgcgtggca ccgggtccgg
1401961 cggatcatgc ccgcctacac cgtcaccgtt ctgttggcct acctcgtcta tcacttccgc
1402021 acggcggggc ccaaccccgg gcacacctgg gtcgggctgt tccgcaacct caccttgacg
1402081 cagatctata ccgacggcta tctgggtgcg ttcctgcatc agggtctgac ccaaatgtgg
1402141 agcctcgcgg tggaggttgc cttctacctg gcgttgccgg cgttggcata cctactgttg
1402201 gtgctcgtct gccggcggcg atggcagccc aggttgctgt tggccaccat ggcggggctg
1402261 acgatgatca gcccggcatg gttgatcctg gtgcacaaca cgcactggat gcccgacggc
1402321 gctcggctgt ggctacccac ctatctggct tggttcgtcg gcggcatgat gctggccgtg
1402381 ctggcggcga tgggcgtgcg ctgttatgca ttcgtggcca taccgttggc ggtcatctgc
1402441 tacttcatcg tctccactcc gatcgcgggc gcgcccacga cgtcgcccac agcgctggcc
1402501 gaggcgctgg tcaagaccgc cttctatgcc gtgatcgccg tgctggcggt ggcaccgctg
1402561 gccttgggtg accaggggtg gtatgcccag ttgctggcca gccggccgat ggtgtttctt
1402621 ggtgagatct cctacgagat cttcctgatc catctggtga ccatggagat cgccatggtg
1402681 gacgtgctcg ggtatcgggt ttacaccagt tcgatggtga acctttgtct cgtgacgctg
1402741 gtgctgacga tcccattggc gtggttgttg caccgtttca ctcgggtcca gggtgaccgg
1402801 ccttcctagc ggcggcagaa gcaggtgtca cgatcgggac gacgaactcc gcgatcatcg
1402861 ctcgttcgtc ggcttcgtca cggccgggga acatcagcag cgatgtgagc atccggacca
1402921 cccagcgggc gcggcgttcg acggtggtcg gatcgtcggg acctagtgag ttgaggaatg
1402981 ccgcggccag ggccgcgatc acctcggacc gtccggccat ctcgccgccg atcggtgggc
1403041 gggtggtggt aaaccacgcg gccaacgcgg ggttgtcgcg gaccatccgc aacgtcgtgg
1403101 tgatgctcac cagcagccgt tcggcaggtt cgacgacatc ggcgatcttc accatgatct
1403161 cgcggccgag ccggcgggtc tcgcggtgca cgtacgcggt tcgcagcgcc tcgcggctgt
1403221 cgaagtaccg atacagtgtt gcgcgcgaac agcctgcggc cttggcgatc tcgttcatgc
1403281 cgatcgacgc cgggtcacgc tgcgtaaaga gtcgctcggc ggcgtcgagt atccgatctg
1403341 cggctaactc ggtccgacgc gcggacagcc agtcggtacc cgccatcagg atgtcactcg
1403401 gaacggcacc gacagcggac gccggacata actgccgccg gaccacacga tgcgtgactc
1403461 ggccacctcg aagtccgggc accgggccag cagttcggtc agcgccaccc ggcattgcat
1403521 ccgggccgcg gccgcaccca ggcagtggtg ggcgccgtgg ctgaaggtca agatgttgcg
1403581 cgggcaccga gtgacatcga gttcggctgc gtccgggccg tattggcgtt cgtcacggtt
1403641 ggccgagccg tacagcagca gcacccggcg accggccggg atggtggtgt caccgatcgt
1403701 gacgtcgcgc gtggttgtgc gcgccagccc ctgcaccggc gaggtgagcc gcagcagctc
1403761 ctcgaccgcg tcggggatgc cctctgggtc atccagcagc agccggcgct ggtcgggccg
1403821 ccggtgcagc aacggcatcg aaccgcctag catgccggtg acggtgtcgt tgccgccggt
1403881 gaccatggtg aacgtgaacg ccagtatgga cagtgtgccg gcggtgtcgc cgtcggcgcc
1403941 gaccccggcg gctaccaggt gggagatggc gtcgtcggcg ggctcggtgc ggcgtcgctc
1404001 gatcagcccg gtgaagtagg ccatcatcga gccgaccgcg tccagtgcgc cggtggtggc
1404061 gccgtcaacc gcgttcgccg ccacgatggc ctgggtccac ccgtcgaatt gcgtccaatc
1404121 ctcttcggga acaccgagat agtgcgccac caccatcgac gggagcggtt tgaatagttc
1404181 ggtgacaatg tcgccgccac cgttggcgcg cagcttttcg agccgctcaa cgacgaactt
1404241 gcgcaccgtg ggctcgacgg tttcgacctg tcgtggcgtg aagccgcgcg acaccagctt
1404301 gcgaaactcg gtgtggaccg gcggatcctg catcaccatg ggcggggtgt cgtgcagtcc
1404361 aatcatttcc agctcgccgt agttaacggt caagccttgc gccgacgaga acgtctgatg
1404421 gtcccgcgct gccgaccaga cgtcggcgtg ccgggacagc acgtagtagt cgtactcggg
1404481 acgctgcggc gggacgacgt ggtgcaccgg gtcgtggtcg cgcaacgcgc ggtacatcgg
1404541 ccacggattc ggccaggttt cggcggtggc gagctggaat tcgtgagaca ttactgatgt
1404601 catgtcttat gtctaagaca ttccatcggt aatatcaatc ggcgattgtg aatctggtga
1404661 cgcgacacgc cgaggacgcg tcgtgcggtt cacactcggc gggacgtcgc gacggatcag
1404721 atcgccgagc cgggattgag gatgccctgg gggtccagcg cttgcttgat gcgctggttg
1404781 agggccagga cgtcgggccc gagatagccg gccaaccacg gccgtttcaa ccggcccacg
1404841 ccgtgttcgc cggtgatcgt gccgcccagg ccgacggcca ggtccatgat ttcgccgtac
1404901 gcgaggtggg cgcgctctag catcgcggca tctgcggggt cgtacaccag caacgggtgg
1404961 gtattgccgt ccccggcgtg ggcgatcacc gagatcatca gattccgctc ctcggcgatg
1405021 cgcgcaatcc cggtgaccag ttcgcccagt gcgggcagcg gtaccccgac gtcctcgagc
1405081 agcaacgccc ccttgctctc gaccgccgga atggcgaacc gccgggccgc aatgaacgcc
1405141 tcgccctcat ccgggtcgtc ggtcgaaaac acgtctatcg caccgttttc ggcgaacacg
1405201 gcggccatca cggcggcgtc ttcggtggcc gcgcggccac gttcatcaga accagccacc
1405261 agcatggccg ccgcatcgcg gtccaggtcc atccgcaagg tgtcctcgac ggcgttgatc
1405321 gccaccgaat ccatgaactc cagcatcgcg gggcgaagtc ggccggtaac cccgagcacc
1405381 gcatcgaccg ccgcctgcac cgagccgaag ctggccacca cgatgctcga tgcattctgt
1405441 gcgggcagca gtcgcaacgt cacctccgtg atgacgccca gcgtgccttc gctgccgacg
1405501 aacagtttgg tcagggaaag cccggcgacg tccttgagcc gtgggccgcc cagccggacc
1405561 gcggtgccgt tggccagcac aacctgcatg cccagtacgt agtcgcctgt gacgccgtac
1405621 ttcacgcagc acagcccgcc ggcgttggtg gcgatgttgc cgccgatgct gcagatctcg
1405681 aacgacgacg gatccggggg ataccacagg ccgtgttcgg cggcggcctc cttcacctcg
1405741 gcgttgtaca ggccgggctg gcacactgcg gtgcgggtga ccgggtcgac ggtgatgtcg
1405801 cgcatctttt cggtggacag cacgatcccg ccatccaggg cggtcgcccc gcccgaaagg
1405861 ccgctaccgg ctcctcgggt caccacgggc acctggttcg cactggccca acgcagcacc
1405921 gtctgcacct cttcggtgcg ccgtggccgg atgattgcca gcggtttgcc ggccgaaggg
1405981 tcaaaggccc ggtcttgccg gtagccgtcg gtgacggcgg ggtcggtgac caccatcccc
1406041 tcgggcagct cggccatcag gccagccagc acatcggtat tcactgagcc gatcctacgg
1406101 gccgatcgat gtccgcttgg ggcgccagat ccagttcgcg cagcgcgggc agccggatcg
1406161 cgaccagccc ggtgcacacg atgggcagtg ccaacgcgag aaacgtggca tgcagtccag
1406221 cggcgtcggt cagtggaccg gccagcaaca gacccaacgg gccggcggcg taggccagcg
1406281 acgtcatcac cccgactacc cggccgcgca gatgctgtgc tgcccgcgtc tgtatcacgt
1406341 agttatagat cggctggatg ggtccgtaca ccaggccgac caccgcgcac aacaccatga
1406401 tgaccggcag tggcggcagg aacgcgatga ccatcgatgc caaacccagg gtaagaaccg
1406461 cggtcgacat ggtcacgcga cggggaacgc ggatagccaa cacggcatac cccagcgctc
1406521 ccaccaggcc gccgccggcg atcgccatca acgcccaacc cagctgcacc ggttgctggt
1406581 ggtcggtgaa gtatttcggg aacagcacgc tctccatcgg cagatacagc gcggtgacgg
1406641 tcaggtcaat catcccgagg gtgcgcaata cccgcaggtt ccagacgaag cgcagcccct
1406701 cggcgatccc ggataccaac ccttggggcc gcgaggtgtg gtgcggcttg ccggcaccct
1406761 cgagttgcag ggcggcaatc gcgaggatgg acaacccgaa tgccgtcgcg gtaatccaca
1406821 ttgtggtgat gccgccaacc gtcgcgatca tcaagccacc gatggccggg ccgacaataa
1406881 aggccaggtt gaggatcgcc tcgtaggcgc cgttgatgcg gtccaacgac cagcctgccc
1406941 gagcggcggc ctcgggcagc atcgagtcac gagccgtcat gcctgccggg ccgaaggcgg
1407001 ccgccagggc ggccaatacg gccagcacca gcacgttgac cgcgtcgccg ccgtaccccc
1407061 acgccaccag ggggacgccg gccaccgccg cacccgacag cgcatcggcc accatcgaca
1407121 cccggcgacg cccgaagtag tcgaccgcgg tgccggcgac cagcgtggcg aacaacagcg
1407181 gcagcatggt cgcactggcc acgatcgagg cctgcccagc gctgccctcg cgctgcaaca
1407241 ccagccacgg aaacgcgact atcgagacgc catcacccgc ggccgccatc agcgttgcga
1407301 acaggatcag gaatgccggg ccgcggttgc tgtttctcat gaatatcgcg gctgaatcta
1407361 gcgccaaacc ggtatggggg ccaccgaatt tctgcgctgc cgcagcccgg atgcaggatg
1407421 ttcgtgtgct catgcatccg aagaccggcc gggcgttcag gtccccggta gagcccggtt
1407481 ccggctggcc aggtgatccg gcgacaccgc agaccccggt ggctgccgat gccgcgcagg
1407541 tgtcagcgct ggccgggggc gctggctcga tctgcgaact caacgcgctg atcagcgtgt
1407601 gccgggcgtg tccccggctg gtcagttggc gtgaggaggt cgccgtcgtc aagcgccgtg
1407661 ccttcgccga ccagccctac tgggggcgcc cggtgccggg gtgggggtcg aagcggccgc
1407721 ggttgctgat cctcgggctg gcgcccgccg cgcacggggc caaccggacc ggacgaatgt
1407781 tcaccggcga tcggtcggga gatcagcttt atgcagcact gcatagggcc ggcctggtga
1407841 actcaccggt cagcgtcgac gccgcggacg ggctgcgggc caaccggatt cggatcaccg
1407901 caccggtgcg gtgtgcgccc ccgggcaact cgccgacacc ggccgagcgg ctgacatgct
1407961 caccctggct aaatgcggaa tggcggctgg tgtccgatca catccgtgcg atcgtcgccc
1408021 tcggcgggtt cgcctggcag gtcgcgttgc gcctggcggg cgcgtcgggg acacccaagc
1408081 cgcggttcgg ccacggcgtc gttaccgagc tgggagccgg tgtgcggcta ctgggctgct
1408141 accacccgag ccagcagaat atgttcaccg gtaggttgac tcctacgatg ctcgacgaca
1408201 ttttccgtga ggccaagaag ctggccggga ttgagtgacg tgaagacggt tgtggtttcc
1408261 ggcgccagtg tggccggtac ggcggcggcg tactggcttg ggcggcacgg ctattcggta
1408321 acgatggtgg agcgccatcc cgggctgcga ccaggggggc aggctattga tgtccgaggt
1408381 ccggcgctgg atgtgttgga acgtatgggg ttactggcag ccgcccagga acacaagacg
1408441 aggattcggg gcgcctcctt cgtcgatcgt gacggcaatg agctgttccg ggacaccgaa
1408501 tcgacgccca ccggcggtcc agtcaacagt cccgatatcg agctgctacg tgacgatctt
1408561 gtcgaattgc tctacggggc aactcaaccc agcgttgaat acctgttcga cgacagcatt
1408621 tccacattgc aggacgacgg cgactcggtg cgggtgacct ttgagcgcgc ggcggcccgc
1408681 gagttcgacc tcgttatcgg tgccgacgga ctgcattcca acgtgcgcag gttggttttc
1408741 ggtccggagg agcagtttgt caagcgatta ggaactcacg cggcgatttt taccgtgccc
1408801 aacttcctgg agttggacta ctggcagacc tggcattacg gtgactccac catggctggc
1408861 gtttacagtg cgcgcaacaa caccgaagcc cgcgctgcac tagccttcat ggacaccgaa
1408921 ctgcggatcg actaccgcga caccgaagct cagttcgccg aactgcaacg tcggatggcc
1408981 gaggacggct gggtgcgcgc gcaactgctg cactacatgc gcagcgcacc ggatttctat
1409041 ttcgacgaaa tgtcgcagat cctgatggat cgctggtcgc ggggcagggt agcgctcgtt
1409101 ggcgacgctg gttattgctg ctcgcccttg tcggggcagg ggaccagcgt cgccctgctg
1409161 ggtgcctaca tcctggccgg cgaactcaag gcggccggtg acgactacca actcggattc
1409221 gccaattacc acgccgaatt tcacggcttt gtcgagcgca accaatggtt ggtcagcgac
1409281 aacatccccg gtggtgcgcc gataccgcag gaggagttcg aacgaatcgt gcattccatc
1409341 acgatcaagg actactgagc gccttcaccc gggcgcagcc aggatggcgc tcgtcggccg
1409401 cttcaccgaa cctgaagatc tgcagacgaa gtacgagtag gggccggcaa atttaccggc
1409461 tcgacgcgca gaagcgccga gatttagcgg cgggtcaata cgacgaccgg gattggccgt
1409521 gacgtccggc tctggtagtt ggtgtatcgg ttggcgttgt tctcgttgac gatctgccag
1409581 agccgcgcgt agtccgggtc gtggggctgc accggtttcg ctgtcacacc gaatcgcttg
1409641 ggcccgacgt tgatttcgac gtccgggttg gccttgaggt tgtggtacca acccggcgag
1409701 cggggatcgc cacctttgga cgccacgatc aggtacgcgt cgccgtcgcg agcataggtg
1409761 agtgacgtgg ttcgcggctg gctcgtcttg gcgccggtgg tatgcagcag caaactcggt
1409821 ggcgcgccgg ggattcggtg tccgatccga ccgttagtgc ctcggtagat cgcgtcgtgc
1409881 agcctgagca gctgcacgcc tacgtggcgc tcaagccatc gggaaatgtc catggggtca
1409941 gtcttgcgca gcggcatcct gttgcgccag cgcctcccgc aggatccgtc cggtggcttc
1410001 ccggtccggg tcgcggcgca gcatcattcc cttggcgacc gacagcttgt cgccgttgcg
1410061 cggcggtaat acgtgcaagt gaacgtggaa caccgtctga aaagcggcac ggccgtcgtt
1410121 gatggcgatg tgtgtcgcgt cagccaactt cgtggcgcgg gccgcccgcg cgatgcgttg
1410181 gccgatggcg accatgtcag ccaacgcctc cggcggggtg tcggtgaggt caacggtgtg
1410241 tcgcttgggc agcaccagcg tgtggccgcg ggtgaacggg cggatgtcga ggatcgcgag
1410301 atagccgccg tcctcgtaga tccggatggc cggagcctcc ccggcgatga tcgcacagaa
1410361 cacgcagggc atgtcgctac ggtactggac ctctcggaga ccgcccaagt gaacgggata
1410421 cgctgccgcc gtggacccta ctgacctggc cttcgccggt gccgcggcac aggcgcggat
1410481 gctggctgac ggtgcactca ccgcgccgat gctgctcgag gtctacctgc aacgaattga
1410541 gcgtctggac agccacctgc gcgcctaccg ggtggtgcag ttcgaccggg cgcgtgcgga
1410601 ggccgaggcc gcccagcaac gcctcgacgc cggtgagcgg ctgccgctcc tgggcgtgcc
1410661 gatcgccatc aaagatgatg tcgacatcgc cggggaggtg acgacatacg gcagcgccgg
1410721 gcacggtccg gccgcgacgt ccgacgcaga ggtggttcgc cggctgcgcg cggcaggcgc
1410781 tgtcatcatc ggcaaaacca acgtgcctga gttgatgatc atgcccttca ccgagtcgct
1410841 ggccttcggg gccacccgga atccgtggtg cctcaatcga acccctggcg gcagcagcgg
1410901 cggcagcgct gcggcggtag cggccgggct ggcgccagtg gcactgggat ccgatggtgg
1410961 cggatcgatt cgtatcccgt gtacctggtg cggtctgttt gggctgaaac cacagcgcga
1411021 tcggatttcc ttggagccgc acgacggggc ctggcagggg ctgagcgtca atggcccgat
1411081 cgcgcggtcg gtaatggacg cggcgttgct actggacgcg accacaacgg tgcctggtcc
1411141 cgaaggcgag tttgtggccg cggccgcacg ccaacccggc cggctgcgaa ttgccttgag
1411201 caccagggtt ccaaccccgc tgcccgttag gtgcggcaag caagaactgg cagccgtcca
1411261 ccaggcaggt gcgttgctac gtgatctggg ccacgacgtc gtcgtccgcg atcccgacta
1411321 tccggcttcg acctatgcca actacctgcc ccgctttttc cgcggtatca gcgacgacgc
1411381 ggacgcgcag gcgcacccgg accgcctcga agcacgtacc cgagccatag cgcgtctagg
1411441 gtcgttcttc tccgaccggc ggatggcggc cctgcgggcc gccgaggtgg tgctgagcag
1411501 ccggatccag tcgatcttcg acgatgtcga cgtagttgtg acgccaggcg ccgcgaccgg
1411561 cccgtcccgc atcggcgcct accaacgccg gggtgcagtt tcgacgttgc tgctggtggt
1411621 gcagcgggtt ccgtactttc aagtctggaa tctgaccggc cagcccgcgg ccgtggtgcc
1411681 gtgggacttc gacggcgacg gcctgcccat gtcggttcaa ctcgtcggcc ggccgtatga
1411741 cgaggcgacg ctgctggcac tggccgcaca gatcgaatct gccagaccct gggcccatcg
1411801 gcggccgtcg gtgtcatgac attgcagtcg cccgctcgtt tttcacgttt ttgcccggcc
1411861 gcaggacatg tgcggcggcg ttaacgttga ctggtgacag accacgtgcg cgaggcggac
1411921 gacgcgaaca tcgacgatct gttgggcgac ctgggcggta ccgcgcgcgc cgagcgtgcg
1411981 aagcttgtcg agtggttgct cgagcagggc atcacccccg acgagattcg ggcgaccaac
1412041 ccgccgttgc tgctggccac ccgccacctc gtcggcgacg acggcaccta cgtatccgca
1412101 agggagatta gcgagaacta tggcgttgac ctcgagctgc tgcagcgggt gcagcgcgct
1412161 gtcggtctgg ccagagtgga tgatcctgac gcggtggtgc acatgcgtgc cgacggtgag
1412221 gcggccgcac gcgcacagcg gttcgttgag ctggggctga atcccgacca agtcgtgctg
1412281 gtcgtgcgtg tgctcgccga gggcttgtca cacgccgccg aggccatgcg ctacaccgcg
1412341 ctggaggcca ttatgcggcc gggggctacc gagttggaca tcgcgaaggg gtcgcaggcg
1412401 ctggtgagcc agatcgtgcc gctgctgggg ccgatgatcc aggacatgct gttcatgcag
1412461 ctgcggcaca tgatggagac ggaggccgtc aacgccggag agcgtgcggc cggcaagccg
1412521 ctaccgggag cgcgacaggt caccgttgcc ttcgccgacc tggtcggttt cacccagcta
1412581 ggcgaagtgg tgtcggccga agagctaggg cacctcgccg ggcggctggc cggcctcgcg
1412641 cgtgacctga ccgctccgcc ggtgtggttc attaagacga tcggcgacgc ggtcatgttg
1412701 gtctgtcctg atccggcgcc attgctggac accgtgctga agctggtcga ggtcgtcgac
1412761 accgacaaca actttccccg gctgcgagcc ggcgtcgcct ccgggatggc ggttagccgg
1412821 gccggcgact ggttcggcag cccggtcaac gtggcaagcc gggtgaccgg ggtggcgcgc
1412881 ccgggtgccg tgctggtcgc ggattcggtg cgggaggccc ttggtgatgc ccccgaagcc
1412941 gacggatttc agtggtcctt cgccggcccc cgtcgcctca ggggaatccg gggtgacgtc
1413001 aggctttttc gagtccggcg aggggccact cgcaccggct ccggcggcgc ggcccaagac
1413061 gacgatttgg ccggctcgtc accgtaggca ggcacaccgg tacacatggg cagacccggc
1413121 gtgactctcg gggggcgtct gacaccgcct tctgcgggtc ttgcgcggcc ggccttcacc
1413181 ccgtcttccg gcactttcga ttggtcacta accgggcctg cttcgatacc aaaaatacaa
1413241 cgtcgaatgg ctgatcacaa tggttctcgc caggccggac gctgttttcg cgccggccag
1413301 gaaccggtgt cacgtttcgc tgccggtgaa cgcgatgtca ttaaagatga aagtatgtaa
1413361 tcatgtaatt atgaggcacc atcacatgca cgggcggcgc tacggtcgcc ccggcggctg
1413421 gcagcaagct cagcaaccag atgccagtgg ggcggcggaa tggttcgctg gccgcctgcc
1413481 cgaggactgg ttcgacggcg accccaccgt catcgtcgac cgtgaagaaa ttacggtgat
1413541 tggcaagctg cctggactcg agagccccga ggaagaaagt gcggcccgag cctcgggccg
1413601 cgtgtcgcga ttccgcgacg aaacccgacc ggagcgaatg actatcgccg atgaagccca
1413661 gaatcgctac ggacgcaagg tgtcctgggg cgtcgaggtc ggtggtgagc gaatcttgtt
1413721 cacgcacatc gcagtaccgg tgatgacgcg gttaaagcag ccggaacggc aggtgctgga
1413781 caccttggtc gacgctggcg tggctcgttc ccgctcggat gccctcgcgt ggtcggtcaa
1413841 gctggtcggc gagcacaccg aggagtggct ggccaagctg cgcaccgcca tgtcggcggt
1413901 ggacgatctg cgcgcgcaag gcccggatct tccggcctaa acggccaccg ccgaatgcgt
1413961 cattccttgt tgactttgtc aacgatcttg gcggcgatct ggcctgcttg attggtgatc
1414021 cggtacccgc atgcgttgac gtcgacgacc acattgttgg ccacgctcat cgcgcgttgg
1414081 cattcccagc cctcagcgcc ttcttgggtg tctatcaccg tgatcgtcgg cgggctgcct
1414141 ttgacgtcgg caaacgtcca ccggtaggtc ttggccttat tcgtgacggt gaccgtcttg
1414201 cctgcgcagt tcttccattt gtcggccgaa gtctgcacga acgcgcgggc tttgtcggcg
1414261 gtcggaaagg cgacgacggc ttggttcacc caatgttcgt agttgtcgcc cggctcggat
1414321 gaaatcaagc cgttgatggc ggtgtagccg gtgccggcat acaccggatc ctggctggta
1414381 tacagcgcgc cctggcagtc cggcagggac accgtcaccg gcgaagagtc catcgatgtg
1414441 atcggtttgc ccggctgcat ggacgacgag cccatcacgg cgttgacttc tgaggagttc
1414501 agcagtaggg cgctaaggcg ctcctccgca accggctgag gcggctgtac cggcttgggc
1414561 cggatggcga tccagatgcc gatggcgccc aacacgagga cgagcacgac ggcggcggcg
1414621 ccggccacta agggccacgg gttggttttg cgcggggtct gggcccaggg gctggggccg
1414681 ccggacggcg gtgcgcccca gccgccgccc tggtagtact gcggggtggg agtgggtccg
1414741 ctggccggca tcgggccgct attgggcgcc caggacggct ggccggtggg gccaggccgc
1414801 tgtccggcag gccccggctg ggccgggggc gtgtaggacg gctttggtgc cggctggaca
1414861 cccggcgggg tgacgggggg tgcgggtggc tgccgaggag ccatggcggt ggccggcatg
1414921 gtcggaggcg ggacgggctt aggcggcgcg ggcagggtgg attcttggct gcggcgcagg
1414981 atgtcggcgg cgtggtcttg gtcggggtcg ctgagcgctt cgtgggcggc cagggccagg
1415041 tcgccggcgc tggcgtagcg gtcttcgggc tttttggcca tgccgcgggc gaccaccgcg
1415101 tcaaaggctt tggggatgcc cgggcggatg gcgctgggct gggggatggg tcccatcagg
1415161 tgggagctga ccagtgtgcc ggcgctgtcg gcgcgatacg gcggggcccc ggtcaagcat
1415221 tcgtgcagca cgcaggccag cgcgtagatg tcggcgcggt aggttacctc gtcgttggag
1415281 aaccgttcgg gggccatgta tttccaggtg cccaccgcgg tgcctaactg ggtcagtttc
1415341 tcgtcggtgg tcgcactggc gatcccgaag tcgaccagat aggcaaagtc gtcgcgggtg
1415401 atcagaatgt tttgcggttt gacgtcgcgg tgcatcaccc cgtcggcgtg tgcggcatcg
1415461 agcgccgagg cgatctgggt gatgatggcc accgcgcgcg gtggggtcag cgggccgaag
1415521 cgtttgagca cgctgtcaag gtcggtgccc tccaccaggc gcatctccaa aaacatttgg
1415581 ccgtcgactt cgccgtagtc gtggatgggc accacgtgag gttcctgcaa ccggccggcg
1415641 atgcgggctt cgcgtttcat ccgctcgcga aacaccgggt ccttgctgaa ttccgcggtc
1415701 atcagcttga cggcgacggt ccactccttg acggtgtgct cggcctcgta gacctcgccc
1415761 atcccgcccc ggcccaacag ccgtttgagg tggtagggcc caaacatcga gcccacccgc
1415821 gagtcctgtg cgtcgctcat cgctgatcct cccaaccaac ccgctgccgc cgacactatc
1415881 aacaacggtc aggtatcacg tcggctgcga tcgccgggcc cagcaacctt gccaggcaac
1415941 aatgacgcta ggccttcgcc ggctcgaccg cacgaaaatc tgccacatct tcgcgggatg
1416001 tcggcgactg cggtggctgt gccattcgct ggtacgcgcc gctgttcggc taccgaaaag
1416061 tgttgtggta attggttacc gcagcccagc gccggcggcc agcgcgcgac gttgccacga
1416121 aaagctttgt gtagcagtca tatccgtgga catcggtgtt aagggcttgt gtccacggat
1416181 ctacgtgccg ccatgcgtcc ccgcgctgat ctggaacgtg aattcatggt cacagatgcg
1416241 aatgtggtcg ccgtcgttca gcgtgaccgc ggagcggatt cgctcgtgct gcacatgcac
1416301 gccgttggac gatcggaggt cgttgatgac gtagttggtg cccgtgtcga cgatgacggc
1416361 gtggtggcgg ctgacgttgg cgctgtctag gacgatgtcg ttgtcatgca gacgcccgat
1416421 ccgggtcgcc gcggcttgca gtgggtagcc gcgacccgag gcgatgtcgt gcaggtaggc
1416481 caccgcctgc tggcccgacg ccatggtgcg ctgatcgagc accgtgacgg tgccggcagc
1416541 ggtggttttg gcggacttct tggcatccag cggttgctga cgcagaatcc gctcgttgag
1416601 agcgcgcaac gtcggaccgg ggtcgatgcc gaggtcgtcg gccagtgttg tcttcacccg
1416661 gcgataggcg cccagcgcat cggattgccg gtcggagagg tagtaggcgg tgatcagctg
1416721 tgtccacagc ggctcccggt aggggtgttc gaatgtcaga gcctcgagct cggcgatcac
1416781 tgcgctggcc cgcccacacg cgatttcggc ctccgccttg gcggtatggg caagaacctt
1416841 gtcttctacc agcgccgtgg caaagggttc gacgaactgg aagtcgcgca ggtcatcgag
1416901 caccggccca cgccattctc tcaatgcggc cgacaggtgg cggctggctt gttcgaaccg
1416961 gccggcggcg gccgcgtgca cgcccgcggt tttttcggca acaaaccgcc ccagatcgca
1417021 agtgttgtcg gggatgctga gccgataacc cggcggcgct gcggccaaca ccacccgtgg
1417081 gtcgatcccg gcgccaccga ggagcttacg cagattagac acgtaggagt ggatactcgc
1417141 gcgtgcgccc gagggtggcc actcctccca gagggcggtg attagggcgt cgactcctac
1417201 gggcctgttg cggttgatga ccaacatggc tagcacagcc cgttgcttgg gggtgcccga
1417261 tggcaccggg gtgccgtcga tagtcatctg caatggtcca agcaggccga agtcgagccg
1417321 cttctccact gtcgcgctac cagccattgc gggtcctccg tggcttgcgg tgccaaggtg
1417381 ccaatagggt gtcgctaccg gtcattgtga taccacgttt cgccgatgcg gtaagaaccc
1417441 aggatctcgg cacgccgtgc gatgtaccgg gtcggtggcc cttgacagcg gcatcggctg
1417501 tttccatgcg ggtgaaatgc tggccctgta aagatgatcg tgaatgtccc acgggaatcc
1417561 tgttggtgct catccaaaca tgcgatcggc gggcagccga cccggtgttc ttgcaacgag
1417621 tggctgcccg ctgtggtgat cgacattcga gcgcggttca ggtggtgacg gccatgaagt
1417681 cgtggctggt ggcccacgcc tcgacgaagg tttccatcgg gatctgctcg tcgcggcccg
1417741 tgggggtacc gctgtcgttg aggtgaacaa tgccgttttc ggtatcgaca ccggtcacca
1417801 ccacggcgtg gtcagaccgc gggttgccgg cactgtcggt ttcctcgacg ggctggcccc
1417861 agatcatctc ggcgttgatg ctgacgatca cggcgtgccc gctgcccaga tactgctcga
1417921 gggcggccat gccggtggcg actccggtgg ctgtggcgtg gtcctcgtcg gtgataacgg
1417981 cgtcgacgcc gtaatgcgcc agcagcgtcg gtatgtcggc cacgctggta cccattcccg
1418041 agttcgggtg ctcggcgtcg gccggctttg tgtagatgga cccggggtgc acgacgctgg
1418101 gtgtcgactg ggccactttg atgatggcgc gctcggaagg ctccctgccg gtcacttgac
1418161 cgatcacgtc cgcggccgac atcaggacgc agtcgtcgta tgtctgctgg cgccagtact
1418221 tggcggcggc tgccgggtcg ccatacatgg tgcccgccgc tgcgtcggcg gggctggcca
1418281 atcccagtgc aacggcaccg gcggccagcg cgaaggtggc ggtcttgaag gcggtggcga
1418341 ttttgctggt cgtcatcgtc ggtccttttc tcgttccgct atgcggagtg gatgttgaga
1418401 aaaggttccg atggtgacct ttttgttatc tctaggaatt cttggagtga tctgcagtgg
1418461 tcagccgagg ttcaccggtc gcgggcaggc cgatctgcgc gggcgcagtc gacagcgttg
1418521 ctaccgggat gcacggcggt accgacgatc ggtcggctgc ctaagcgggc gtgcgggatt
1418581 agttgcaggc ccaggtgtcg atgtagccgc cgccgagctt ggtcagggcg tccttcatgg
1418641 cggcggccaa ggtgggtcca actcctccct ggtatgccct atcgttggcg gcgacggcgc
1418701 cgcaggcggt gaaactggtg agcaccttgc agtcggagta gccacacgac ttgacggcgg
1418761 tggcttcggc agccgcccgg gttgggtagt cccacgatcg gccccacgag ccgttgccgg
1418821 agtaggcaat tgcgccatag acatcggcgg catttgctgg tgcgggagcc agggtgacgg
1418881 tcgtcgcggc ggcagtggcg acgccggcga cggccaccgc gaaccgtcgc cgaagagtaa
1418941 tcatcgtcgt cattggtgag tcctttccga atgccggcgg tgcggcggtt tcaacaagca
1419001 attaggacga tggctagacc ggtttggtgg cggtgacctg cttaccccag tcggacatcg
1419061 tcaacgtcac cgacgtgtct ttggtgggag cgatctggat ctggaccaag tgcgaggatc
1419121 catccgaagc gatccagacg gtggtgggca ccgttttgac gtcttcggag gtcagacgtg
1419181 agccggccag cgtcgcgatg tcgtcagcag acgagttccc ggtgatcttg gtggtcgcga
1419241 caccgtccgc ctgctggctg ccggcaaccg acgcgtcctt gaggttagcc aacaggttgg
1419301 ccaggccctt gttggggtcg aggagcaccg acacgttgta gatcgaggcg ccgttgccga
1419361 aatcggtgta ggtgccgggc tggcctaggt cggagtacag gtgaccgtca acatagacga
1419421 acttcgcgtc ttcgctcttg ttgccgacga gcaatgtcgc gctaccggtg gcaaccgtct
1419481 gcggtgtgtt ggagatatcg ccttcgagct tggtcacccg caggtttggc acgtcgcctg
1419541 tcaccgcaag tctgacgtgc attccggtga ccttgcgcat cgcatcggtg gcctgcttga
1419601 gtagcatggc cgcatcgccg ttggatgccg tggccgcggt gtcagacgct ttgccggcgt
1419661 ccccttcggt tgagcagccg ccgatcgcca ggacgacggc gagtatggcg gtggcggcgg
1419721 caacaacgga acaaggtgga tgcttcatcg aaatctcctc atgttggccc acagcttcgt
1419781 actgcatagc aatcccgttg cggcagagtc aacagccgac accgagtccg agtgagcgcc
1419841 gcacggcacc gcgagtcgaa tcggccgaat tgaatggcgt ttcaaacgct ttcgttgtcc
1419901 ggcggcaaag cgaatgcggg gatcccggtt gacgggatcc ccgcatcggg tgggcagcgg
1419961 ctaggtgagc tggctggcgt attgcgggca gtaggccttg gttgcgtcga cgacgaagta
1420021 ggctgcctgc ttagtggtca ggttggtttg gctgaggacc tcctcggcga tctcggtgcc
1420081 ggtttcgccg ctggccagct tcttgcagac cagctgggct tgctgggtgg ccacctgcgg
1420141 tgaggagaag gtgacgccaa tggactccat ctgagcaatg aaggcttcgt ctttggtgtt
1420201 ggcgccggcg gtgccggcgg tggcgacggc aagtccgatg gcggcggcgc cgactgcagt
1420261 ggtgaacgct gcgataatgc gaggcgataa cggcgataac atggtcaaga tccttcgcgg
1420321 tcgggatttc cctggatgac ctcagcttgc ggggggcgcc ttggcggatt ctcaacaact
1420381 tcttggtaac ctcgtgggcc cgcgtcgggc taggcccgcg tcatctggta atagaccccg
1420441 cgccgggcca acagctcggc gtggttgccg cgttcgacga tctggccggt ctggaccacc
1420501 aggatgtggt cggcatcgcg aatcgtcgaa agtcggtggg cgataatgaa actcgtacga
1420561 tcccggcgaa gctcgcgcat cgctcgctgg atgagcagct cggtgcgggt atcgaccgag
1420621 ctggtcgcct cgtccaggat caacagctgc gggcgggcaa gaaaggcgcg ggcgatggta
1420681 atgagttgct tctcgccgac gctgatgctg ccgccgtcgc cgctgacccg tgtctggtag
1420741 ccagcaggca gtgtgttcac aaaccggtcg acatgggccg ccctggcggc ttctactatc
1420801 tcgtctgtgg tggcctccgg ccgtccgtag gcgatgttct ccgcgatggt cccgtcgtag
1420861 agccaggtgt cttgcaacac catgccgatt cgcgatcgca gcgactgccg gcttaccgag
1420921 gcgatatcca ccccgtcgat caggattcgt ccggaaccga tctcgtagaa ccgcattagc
1420981 aggttcacca gcgtggtctt gccggctccc gtcggtccga cgatcgccac cgtgctaccc
1421041 ggttcggcca ccagcgacag gtcgcggatc accggcgtgc ccgggaggta agcaaagttc
1421101 acgtgctcaa actcgacccg tccggttagg ttcggcagct ccggctcagg ctccggcgac
1421161 tcctcgggct cgtcgagcac gtcgaacacc cgctccgcgc tggccacccc ggactgcagg
1421221 gcgttgtaca tcccggccag ctggctcagc ggcatgttga actggcggat gtactggatg
1421281 aacgcctgga tgctgccgag cgtgatctgc ccggtggcta cctgcaggcc accggccacc
1421341 gcgaccgcga cgtagccgag gttgccgatg aacgccgtcg ccggctgcac gagaccagag
1421401 aggaactggg cgccgaaacc ggcctggtag acgtcgtcat tcaactcgtg gaaccgttct
1421461 cgtgcggccg cttggtggcc gaacgtcttg actaccgtga acccgctgta ggtctcttcg
1421521 agatgggcgt tgaggcgccc ggtgctggtc cagtgagcta cgaatagggg ctgtgaccgc
1421581 cgggtgatcg cgcgtgtcac cagcagcgac agcggcaccg tcagcagtgt gatcagcgcc
1421641 agcaggcccg agatcgacac catcatggcc agcaccgcca ccatggtcag aatcgacgtc
1421701 accagctggc tgatcgtcat tgacagcgac gactggaggt tgtcgatgtc attggtgacc
1421761 cggctcagca gctcaccgcg ctgttgtccg tcgaagtagg acagcggcag ccggtgcacc
1421821 ttgtcttcga catcggtccg caacctgacc atcgttttct gcacggtgag gttgagcagc
1421881 cgggcttgtg cccaaatcat cagcgctgca gccagataca gcgccaacgc cagcgccagt
1421941 gttcgctcca ccgcggcgaa gtccacacct tggcccggca ccacgttcat cccggacagc
1422001 aggtcggcga aggtgttgtc accacgggcc cgagccgaag cgacggcctg tgccttggtg
1422061 attccccccg gtagccctcg cccgatcacg ccgttgaaca gcaaatcggt ggcatggccg
1422121 aggatccgtg gaacgatgac gccgatcgtc gtgccggcga ttcccagtgt gatcaccgcg
1422181 atgctcagcc ggcgttgtgg cgccagccgt ttcaccagtc gggctgccga tccccagaag
1422241 tcgcgggacc gcatgttcgg gggcgggctt gcggcacggg ggcgtgcgcc cggtggcgcg
1422301 gtcaccctac acccccgacc gtggcgctca gcgattgtga ggcggcgaat tcggcatagg
1422361 tggggcaatc ggccagcagc gtttcgtggg tgcccgtgcc gacgatctta ccgttatcga
1422421 caacgatgac ctggtcggcc tgagcggcat tcgaaatccg ttgtgtaaca acaatgatgg
1422481 ttgcatcacc agatacctgt cgcagcgatg cgtggacttt ggcgtcggtg tgcacgtcaa
1422541 gtgcggagaa cgcgtcgtcg aacacataga tggccggacg tcggatgacc gctcgggcta
1422601 tcgccagccg ttggcgctgc ccgccggaga agttgacacc accttgggcg acacgcgtct
1422661 gcagcccgtc tgtttgtaca aagccgtcgg ccgcggcgac ccgcagcgcc tcccacatct
1422721 cctgctcggt gactacctgg tctgggcccc cgccgtagcg caggttgtcc gcgacggttc
1422781 cggagaagag gtagctgcgc tggggcacca gcccgatcgc tgaccagagc cgctcggtgt
1422841 ggtactcgcg gacgtcgata ccgtcaacca agaccgcgcc agcggtgacg tcgtagagcc
1422901 ggcagatcaa cgacaccagt gtcgacttgc ccgaaccggt actgccgacg atcgcggtgg
1422961 tggtaccggg ccgcgcagtc aacgaaatgt cctgcagcac cgggcagtcg gcgccaggat
1423021 aggtaaaggt tgcgccagcc aagcgcacta cgcccgtgac cccgtccgtc gggaacttgg
1423081 gattgtcggg gttaccgagt gcggcgggcg tggaaagcac ctcggtgatg cgttcggcgc
1423141 agaccgacgc tcgtggcagc acggccagcg tcatggtcgc catcaacacc gccatcagga
1423201 tctgggcgaa gtaggacagg aaggcgatca gggagccgac ctgcatctgg ccgctgtcga
1423261 tgcgtagccc accgaaccag atcagtgcga cgctggatgc gttgatggtc agcgtggtca
1423321 ccggcagcat cagtgcttgc cagttgccgg cgctcagtgc ggcattcgac agcgccgtat
1423381 tggcctgcgc gaacttgtcg cgttcatagc cttcgcgggt gaaggcgcgg accactcgca
1423441 ccccggacag ctgatcgcgc atcacccggt tgatgccgtc gatcaggctc tgcatgcggc
1423501 ggaagagcgg cagcatgtgg gagatgatcc agtagtttgc tacggccaga atcggaacgc
1423561 tgaccagcag cagccatgtc agcgcggcct cctggtggat ggccatgatg attccgccga
1423621 cgcacatgat cggtgcggtg accagcacgg tggcggtcat ctggaccagg aacaggatct
1423681 gccggacgtc gttggtgctg cgggtcaaca acgtcggagc gccgaatcgg gcggtctcgc
1423741 gttccgagaa ggtgatgatg tgttcgaaca ttgccgagcg caggtcacgg ccgaaacccg
1423801 ccccggtccg ggagcccaga tagaccgccc cgatcgcgca cagcacctgc aatccggtca
1423861 ccccaagcat caccgcaccc agccgtacga tggtggcggt gtcgcccttg gcgacgccgt
1423921 cgtcgacgat tgcggcgttg accgtcggga ggtatagcga agccagggtg ctgaccagct
1423981 gcagcatcat cagcatcgcg accagccggc ggtacggtcg gatgtgctgg cgcagcaggg
1424041 ccaggagcat tgggtaactg tcgcacactg cgcatgctgc ctacccgcgc caggcatgag
1424101 tcttaggccg aaatgcctgg ttaactggcg tgtcgtggtt gacccgcggg cctgcggcta
1424161 cagtgcatgc tgtgatcggc agtgggagag gtagcggtgc ggcgtaaggt gcggaggttg
1424221 actctggcgg tgtcggcgtt ggtggctttg ttcccggcgg tcgcggggtg ctccgattcc
1424281 ggcgacaaca aaccgggagc gacgatcccg tcgacaccgg caaacgctga gggccggcac
1424341 ggacccttct tcccgcaatg tggcggcgtc agcgatcaga cggtgaccga gctgacaagg
1424401 gtgaccgggc tggtcaacac cgccaagaat tcggtgggct gccaatggct ggcgggcggc
1424461 ggtatcttgg gcccgcactt ctccttctcc tggtaccgcg gcagcccgat cgggcgggaa
1424521 cgcaagaccg aggagttgtc gcgcgcgagt gtcgaggaca tcaacatcga cggccacagc
1424581 ggtttcatcg ccatcggtaa cgagcccagt ttgggtgact cactgtgtga agtcggaatc
1424641 cagttctccg acgacttcat cgaatggtcg gtgagtttca gccagaagcc gttcccgctg
1424701 ccgtgcgaca tcgccaaaga actgacccgc caatcgattg cgaattcgaa atgagacgtg
1424761 tcctggtcgg tgcggccgcc ttgatcaccg cactgcttgt cttgaccggc tgcacgaagt
1424821 cgatttcggg taccgccgtc aaggcgggtg gggccggtgt cccgcgcaac aataactccc
1424881 aggagcgcta ccccaacctg ctcaaggaat gtgaggtcct gaccaccgac atcctggcca
1424941 agaccgtcgg tgccgatccg ctcgacatcc agagcacgtt cgtcggcgcg atctgccggt
1425001 ggcaggcggc caacccggcc ggtctgatcg atatcacccg gttctggttc gagcagggca
1425061 gtctgagcaa tgagcgcaag gtcgccgagg gcctgaagta ccaggtcgag acccgcgcga
1425121 tccagggcgt ggactcgatt gtgatgcgga cgggcgatcc caacggcgcc tgcggcgtcg
1425181 ccagcgacgc ggcgggagtg gtcggctggt gggtcaatcc ccaggctcct ggtatcgacg
1425241 cctgcgggca ggcgatcaag ctgatggagc tgacgctggc aaccaacgcc tagcgctggg
1425301 cgaggcggga gcgtgggcgt gagcgcgcgc agttgtacgg cactaacggc gtgtcggggt
1425361 acagacacgc gcgctcgcgg gttcggctgc cttcaaaagg aagtacgcgg ctgacggttt
1425421 gcggagcaag agcacctcta ccgtggcacg tgaaagccga ccagcgcggc acaccccggt
1425481 tcgacgtctg cccagtgtcc ggcgacgcgt agcacggcga tccccgacgt cgggaacttc
1425541 tccgagatgc gttccgcgac agcggcgtcg gtgccgctga tgctggccag gacgatggca
1425601 agggccgacg tcgttggctc gtgcccgacc acaagcagtg tggtgacgtt gtcgccaacc
1425661 cggttgatct cctcgatcac tgttccgggt gccgcgccgt agagccgctc ggcgtagcga
1425721 gcgggtgcgt cgatgccggt gtgcgccaag gtctgccggg cgcgcgtagc cgtggagcac
1425781 agcacggcat cgacggccgg caggttggcg cgcagccagc caccggccag cccggcctcc
1425841 cggatacccc gcggcgctag cggccggtca tggtcggcga tcccgtccgg gtacgcagac
1425901 ttcgcgtgtc gcatcagcac caggttgcgg tattgctcat tcactgggct gacgttagtt
1425961 cagtgacgtg cccgggatcg ctacggttgg tcgtcgtcct ggtccccgcc gcgctccgct
1426021 ggcatgggac agacttcgtt gcgatcgcct agctcgagcc gaggcgtcag ccatagggcg
1426081 ctgataggta gggcgagcat tctgtgccca aaggataggg ctggcatcgc ccgggcaagc
1426141 acgggcggca tgctgccccg ccggtgagtc cgcgcccggg acctgccggg cgaggtcccg
1426201 cgccttgtcg gtgtgcagac ctacactcgc tttgcgttga cagccacgca ctcaggaggg
1426261 atgggatgcg attcctgcac actgccgact ggcagctcgg catgacgcgt cactttctcg
1426321 ccggtgacgc ccagccgcga tattctgctg cccgccgtga cgcagtcgct ggactaaaag
1426381 cgctggccgc cgatgtgggc gccgaattcg tcgtagtcgc cggtgacgtc ttcgaacaca
1426441 atcagctcgc gccacagata gtcggtcaat ccttggaagc catgcgcgtg atcggccttc
1426501 cggtctatct gctgccgggt aaccatgacc cgctggacgc ttcgtcggtg tacaccagca
1426561 cgctgtttcg agccgaacgg ccggacaacg ttgtggtgct cgaccgagct ggcgtccacg
1426621 aggtccggcc gggagtccag atcgtcgcgg cgccgtggcg gtccaaggcg cccaccaccg
1426681 acccggttgc cgaggtgctg gccggcctgc ccacagacgc cgctattcgg ctgctcgtcg
1426741 cccatggggg tgtcgacgcg ctggaccccg accacgacaa accgtcgctg atcaggctcg
1426801 ccgcactcga cgacgcgctg actcgacagg cgattcatta tgtggcccta ggtgacaaac
1426861 attcgcttac ccaggtcggc agcagcgggc gggtctggta ctccggtgca ccggaagtca
1426921 ccaacttcga cgacgtcgaa ccggaccccg gtcacgtcct agtggtcgac atcgacgaaa
1426981 gcgacccgcg acatcccgtc accgtcgacg cccgtcgcat cggccgctgg cggttcgtta
1427041 cgttgcacca ccaggtcgac accagccggg acatcgccga cctggacctg aacctggatc
1427101 tgatgacgga caaggaccgc accgtggtgc ggctggccct gaccggttcg ctgacggtca
1427161 ctgaccgcgc cgcattggat acctgtctgg acaagtacgc gcggttgttc gcctggctgg
1427221 gtctgtggga acgtcacacc gacctagcgg tgatacccgt cgacgccgag ttcaccgacc
1427281 tcggcatcgg ggggttcgcc gccgcggccg tcgacgagct agtcgcgacc gcgcgcgggg
1427341 gtgacgacga gtccgccgtc gatgcccagg cggcgctggc actgttgctg cggctcgctg
1427401 accggggagc ggcgtgaagc tgcaccggct ggccctgacc aattaccgcg gcatcgcaca
1427461 ccgtgacgtc gaattccccg atcatggagt ggtggtggtg tgcggcgcca acgagatcgg
1427521 caagtcctcc atggtcgagg cgctggacct gctgctcgag tacaaggacc gctcgacgaa
1427581 gaaggaagtc aagcaggtca agccgaccaa cgctgatgtc ggctccgagg tcattgccga
1427641 aatcagcagc ggcccttatc gtttcgtcta ccgcaagcgt ttccacaagc ggtgcgagac
1427701 ggagttgacc gtgctggcac cgcgccgcga gcagctgacc ggcgacgaag cgcacgagcg
1427761 ggtccggacg atgttggccg aaacggtcga caccgaactg tggcatgccc agcgggtgct
1427821 gcaggccgcc tcgacggccg cggtggatct gtctggctgc gacgcgctct cgcgtgcgct
1427881 cgatctcgcc gccggtgatg acgccgcgct gtcgggcacc gagtcgctgc tcatcgagcg
1427941 gatcgaggcc gagtatgcgc gctacttcac cccgaccggg cgccccaccg gagaatggtc
1428001 cgcggcggtc tctaggctgg cggccgccga ggccgcggtg gccgactgcg cggcggcggt
1428061 agccgaggtc gacgacgggg ttcgtcgcca caccgagctc accgagcagg tggctgagct
1428121 gtcgcagcaa ctacttgctc accagctgcg gctcgaagct gcgcgagtcg ccgccgagaa
1428181 gatcgccgca atcaccgacg acgcccgcga agccaagctg atcgctactg ccgcggccgc
1428241 gaccagcggc gcttccaccg ccgcacacgc cggacggctg ggcctgctca ccgaaatcga
1428301 cacgcgcact gcggccgtcg ttgctgcgga ggcaaaagcg cggcaggccg cagacgagca
1428361 ggcgacggcg cgcgcggagg ccgaggcctg cgatgccgcg ctcacggagg caacccaggt
1428421 attgacggcc gtccgccttc gcgccgagtc ggcccggcgc accctcgacc agctcgccga
1428481 ctgcgaggag gccgaccggt tggccgcccg gctggccagg atcgacgaca tcgagggtga
1428541 tcgcgaccgg gtctgcgcgg agctgtccgc ggtcacgctg accgaggagc tactgagtcg
1428601 gatcgaacgt gctgcggcag ccgtcgatcg cggcggtgca cagctggcgt cgatctccgc
1428661 ggcggtggag ttcaccgccg ccgtcgacat cgagctcggc gtcggcgatc aacgggtgtc
1428721 gctgtccgcg ggccaaagct ggtcggtcac tgccaccggc cccaccgagg tcaaggttcc
1428781 cggcgtcctg accgcacgga tcgtcccggg cgcgaccgca ctcgactttc aagccaaata
1428841 tgctgcagca caacaggaat tggctgatgc gctggcggct ggagaggtcg ctgacctagc
1428901 cgccgcacgc tccgccgatc tgtgccgacg cgaactgctg agccgccgcg atcagctgac
1428961 cgccactctg gccggcctgt gtggcgatga acaggtcgac caactgcgtt cccgcctgga
1429021 acagttgtgt gccggtcaac cggccgagct cgatctggtt tcgacggata ccgctacggc
1429081 ccgcgctgaa ttggatgcgg tcgaggcggc tcgaatcgcc gcggagaagg actgcgagac
1429141 ccgccgtcag atcgctgctg gcgccgctcg ccggctcgcg gagacatcca cgcgggcaac
1429201 ggttctacag aacgcagcgg ccgccgaaag cgccgagctc ggtgcggcca tgactcggtt
1429261 ggcctgtgag cgggcgtccg tgggcgacga tgagctcgcc gccaaggccg aggccgacct
1429321 gcgggtactg cagacggccg agcagcgagt gatcgacctg gccgacgagc tcgcagctac
1429381 ggcgccggac gcggtagccg ccgagctggc cgaggccgcc gacgccgtcg agttgctgcg
1429441 cgaacgtcac gacgaggcca ttcgcgcgtt gcacgaggtc ggcgtcgaac tctcggtgtt
1429501 cggcacccag ggccgcaagg gcaagcttga tgccgccgaa accgagcgtg agcacgccgc
1429561 cagccaccac gcgcgggtcg ggcgccgggc ccgggccgcc aggctgctcc gctcggtgat
1429621 ggcacgccac cgcgacacca cccggctgcg ctacgtcgag ccataccggg cggagctaca
1429681 tcggctcggc cgcccagtgt tcgggccctc tttcgaggtc gaggtcgata ccgatttgcg
1429741 catccgcagc cgcaccctgg acgacagaac cgtgccctac gagtgcttgt cgggcggggc
1429801 caaagaacag cttggcatcc tggcgcgatt ggccggcgcg gcgctggtcg ccaaggagga
1429861 cgccgttccg gtgctgatcg acgacgcgct ggggttcacc gatccggagc gactagccaa
1429921 gatgggggag gtctttgaca ccatcggcgc cgacggacag gtgatcgtgc tgacgtgcag
1429981 tcccacccga tacggcggtg tcaaaggagc gcaccgcatc gatctggacg ccatacagtg
1430041 agcccgaaac ggggacatgc gatggacact cagagcgact acgtcgtggt cggtaccggc
1430101 tcagccgggg cggttgtggc cagccggctt agcaccgatc cggccacgac ggtggtggcc
1430161 ctggaggcgg ggccgcgtga caagaacaga ttcatcggcg tcccagcggc gttttccaag
1430221 ctgttccgca gcgagatcga ctgggattac ctaaccgaac cgcagccgga gctcgacggc
1430281 cgcgaaatct attggcctcg tggcaaggtg ctcggtggct cgtcgtccat gaacgcaatg
1430341 atgtgggtgc gtggattcgc atcagactac gatgagtggg ccgcgcgagc cggtccgcgg
1430401 tggtcgtacg ccgacgtgct cggctacttt cgccgcatcg agaacgtcac cgctgcctgg
1430461 cactttgtca gcggtgacga cagcggagta accggtccgt tgcatatttc ccggcaacgc
1430521 agcccaagat cggtgaccgc agcgtggctg gcagccgcac gtgagtgcgg atttgccgct
1430581 gcgcggccga attcccctcg accggaaggc ttttgcgaga ccgtcgtcac ccagcgccgc
1430641 ggtgctcgat tcagtactgc cgacgcctat ctgaagcccg cgatgcgccg taaaaacctc
1430701 cgtgtgctta ccggcgccac tgctacccgg gtggtcatcg acggcgaccg ggccgtcggc
1430761 gtggaatacc aaagcgacgg tcaaacccgc atcgtctacg cccgccgcga ggtggtgctc
1430821 tgcgctggtg ccgtcaacag ccctcagctg ctgatgctct ccggcatcgg cgaccgcgac
1430881 cacctcgccg aacacgacat cgacaccgtt taccacgcgc ccgaggtcgg gtgcaacctg
1430941 ctcgatcatc tcgtcacggt gctgggtttc gacgtcgaaa aggacagctt gtttgccgcc
1431001 gagaagcccg gccagttgat cagctactta ctgcgacgcc gcggcatgct cacctccaac
1431061 gtcggcgagg cgtacggatt tgtccgcagc cgacccgaac tgaagctgcc cgatttggag
1431121 ttgatttttg ccccggcgcc gttttacgac gaagcgctgg ttccaccggc tggtcacggt
1431181 gtggtattcg gcccgattct ggtcgcgccg caaagccgtg gccagatcac gctgcggtcc
1431241 gccgatccgc atgccaagcc tgtcatcgaa ccgcgttacc tgtccgatct cggtggcgta
1431301 gaccgggccg ccatgatggc gggcctgcgg atatgcgcgc ggatcgcgca ggcccgcccg
1431361 ctcagagatc tccttgggtc catcgcgcga ccgcgcaaca gcaccgagct ggacgaggcc
1431421 actctcgagt tggcgctggc cacttgttcg cacaccctgt accacccgat gggcacctgc
1431481 cgcatgggca gcgacgaggc cagcgtggtg gatccgcagc tgcgggtccg cggtgtcgac
1431541 ggactccgcg tcgccgacgc gtcggtgatg cccagcacgg ttcgtgggca tacgcatgcg
1431601 ccgtcggtgc tgatcgggga gaaggccgcc gacttaatcc gcagctgagc tggtcgccgc
1431661 cggctcagcg tcgcatgaac ccgatggcgg tgtagtccag gtctgccaga cccgtcgcgc
1431721 cgaagttggc cagcgtgctg cggaccgcaa cggtgccggg cgactgggta agcggcaggc
1431781 tgaatccttc ggcccagatc agctcgtcga cctggttggc caaggccctc gccttgccgg
1431841 gatcgagttc tgccagcgtt cgctcgatcg cggcgtcgat ttgcgggcta ccgatcttgc
1431901 cgaagttgct ttccccgtcc gaagcgtaga tctgggtgag cgatgacagc ggaaacgcgt
1431961 cgcccaccca gccgaactgt gcgatgtcga aagcccccac gttgacgtag tcgctgaaga
1432021 aaccgctgcc ggacttggcc tgaagttcga gtttgacgcc gatctgcgcc agggtgtgtt
1432081 gggcgatctg ggcgaactgc cgggtgcttt gtgcgtcgta gaacagatcg cggatgacga
1432141 gctggcgacc gtccttctcc cggaacgcgc cgcttcgcct ccagcccagg gcgtccagct
1432201 cccgtttcgc ttgttccggg ttgtaggcga caacgccgct gttgtcctgg tagccgtctt
1432261 ggccggcgac gaagacgtgg ttgttcagtg gcaccgggtc gctggtgagg ccgtattggg
1432321 cgaccctggc gatggtgtat cggtcgatgc ccttggcgat cgccaggcgc agcgccttgt
1432381 cggcgaggat cgacccaggc gcaccgttga gggtgaagtg ataccagctg ggcccggggg
1432441 cgcgccggat cgagatgccc ttggtgcgcg ccgcgatggt cagctggtcc agtgtgccga
1432501 cgccggtggc gtcgattgtg ttgttctgca gcgccggcag ccgggcggca tcatcgagca
1432561 ccaggtatgt gatgctgtcc aggcgtggcc gtgcccccca ccatctcggg ttacgggtca
1432621 acacgattcg ctgcgcggtg cggtccaggg cagacacgac gaacggaccc gccgacggac
1432681 cgggcccatc gagttgaccc ttattgaatg cctcgggtgt ggcggtcata ctggccggca
1432741 gcagcatgcc gttgcccgcg aacataccgc gccactccgc gtacggcttg gcgaacgtca
1432801 ccacggcctg ccggtcgtcg acccctctgg ttaccgacgc cacacgctcg gcgccgctgc
1432861 tagaagcgat ctcgaatgcc ttgtcggcgc cgctgatcgc atgaatctgg ctggcgatgt
1432921 cccgccaggt gatcggggtc ccgtcggacc acaccgcctc gggattgatg gtgtaggtga
1432981 ccacctgcgg ggcggtcctg gtcagctcga tgctggtgaa gtagttggtg tcgaccgtcg
1433041 tcgagccgtc cggtccgatg atgaacgcgc gcggcaaggt ggctttcatc atcgccgcga
1433101 cctcggcgtt gttgccgtcg atgtgcaaga tgttgaagtt gggcggaaag tcggtgagcg
1433161 acaggcgaag attgccgccg tcttgcaacg tggcgggatc ctgctgattg atgtcgctgg
1433221 tggtgccaac cgcggccctg cggtccgcag tgggcgcgag ttcgagttgg gtaccggagg
1433281 ccgagcatcc ggtgagcacc atagccacga cgagcggtgt taataacgcg aaagcccaat
1433341 atcgagtctg cgtccagggt ctggatttcc cctgaaacga cgccctgagc gcagacgcga
1433401 tgcccggggc gcagcctcgt cgctggccac ggtcagccac gacgggccgg atccggttgc
1433461 ggtaccgcgc ccagcagtcg cctggtgtac tcgtgtttcg gattgccgaa gacctcctca
1433521 ctgtcgccct gctcaacaac ggtaccggca agcatgaccg ccacctggtg ggcgaggtgt
1433581 ttgaccaccg aaagatcgtg ggaaacaaat aaatatgaca acccgaactg ctcttggagg
1433641 tcgagcagca ggttgatgat cccggcctga atggagacat cgagtgccga caccggttcg
1433701 tcgagtgcca ggatcttggg ttggagcgcc agtgcccgcg cgatgccgat gcgctgcttc
1433761 tgaccgccgg agaactcggc gggataacga ctggcgtcgc cgtggcgcag tccgacgata
1433821 tcgagcagct cggcgacccg cgcgtgagtc tcgttcttgc cgaacccatt ggcctgcaat
1433881 ggttcggcaa tcagatcgaa gaccggcagc cgcgggtcta aggacgccac cgggtcttgg
1433941 aagaccacct ggatgtcgcg gcgcagcgat cggcgttccg ctgtccccag cgtggcgacg
1434001 tcagtgccga ggacttcgat cgatcccgat tgcggcgcag ccagctccag gatctcgtgc
1434061 agggtggtcg acttgcccga accggattcg ccgacgatac ccaacgtgcg gccctgccgg
1434121 agttcgagac tgatgccgtc gaccgcgcgg acctcgccga tcgcccggcg cagcaccacg
1434181 cccttggcca gccggtaggt tttgactaga tgacgtaccc gcacgaccac cgaggcgtcg
1434241 ccgagtgcag ccgggcgggc ctcggttttg acccggtaga tgtcggcggc gctgcgcccg
1434301 gtgaccagct cggtgcggat gcaggccgcc cggtgatcgg tagcgacgtc aagcaattcg
1434361 ggttccgcgg taaggcattc gtcgatgact agcgggcagc gcggcgcgaa cgggcaaccc
1434421 ggtgccaagc ccgccagcga cgggggcgca cccggtatcg gcaccagccg ggtgccctgc
1434481 gcggcatcca gccgggggac cgagcctaaa agccccacgg tgtagggcat ccggcgatcg
1434541 cggtacagat cattcacccc ggccgactcg acgacccgtc cggcgtacat caccagcgcc
1434601 cggtcggcga actcggccac gacgccgagg tcgtgggtga tgatcagcac cccggcgccg
1434661 gtgacgtcgc gcgccgcctt gaggacgtcg aggatctgcg cctgcaccgt gacgtcgagc
1434721 gccgtggtcg gttcgtcaca gatcaacagg tcgggatcgt tggcgatcgc gatggcgatc
1434781 accacgcgtt ggcgttcgcc acctgaaagc tcatgcggaa acgcacggga acgccgctgc
1434841 ggctgcgaaa taccgaccag gtcaagcagt tccaccgcac gccgacgagc ggccttcttg
1434901 ccaacacggg gctggtgcac ctcgatggcc tcggcgattt ggtcgccgac ggtgtagaca
1434961 ggggtgagcg cagacatcgg atcctggaac accgtgccga tcgccttgcc tcgaaaccgg
1435021 gacatcgcgt tgtcggcaag ccccaacagt tcggtaccct gtagccgaac cgaaccacgc
1435081 acctgcgcgt actcgggcag caggcccacc accgccatcg ccgctgcgga cttacctgaa
1435141 cccgattcgc ccaccatcgc gaccacctcg ccgggctcga cgcggtagct gatcccgcgc
1435201 accgcggtca ccggatcgcc atcggtcctg aaggtgacgg ccaaatcggt cacctcgagc
1435261 agggggctca tcgcacacca cggcgcaggg atctgctggc tgggtccagc gcgtcgcgca
1435321 ggccatcgcc ggtcaggttg gcgcacacca gaatcaacac caggatactg gcgggaaaca
1435381 agaacaccca cgggaacgcg gtcgcggatg cggtgccgtc ggcgatcagg gtgcccagcg
1435441 acacatccgg cggttgaata ccgaaaccaa ggaagctcaa cccggtttcg gccaggatgg
1435501 cggcggcaac attgagggcg gcgtcgatga tcaagatgga tgcgacgttg ggcaccacat
1435561 ggccgacgat gatccggcgg ctggagacac ccatatatcg tgcggccctg atgaattcgc
1435621 gttctcgcaa gctcatcgtc atcccgcgca ccatgcgaga gctgatcatc cagccgaagc
1435681 cggccaacaa caagacaaga aacatgatgt ttgccgagtt cttggttcgc ggggtaacga
1435741 tggcgatcag gatgaagctg ggcactacta gcagcagatc gaccacccac atcagtgtcc
1435801 ggtcccgcca gccgccgaaa tatcccgaga tcgctccaac cgtggcagcg ataccagtcg
1435861 agatcaccgc aacgcaaaca ccaatcagca tcgacttctg catgccacgc agcgtctgcg
1435921 ccagcagatc ttggcccagc gcgttagtgc ccagccagtg cttggtgccc ggcggctgca
1435981 gcaatgcgtt gaaatcaagg tcgtcgtagg agtagggcaa tagtgggggc agcgcataag
1436041 cgctgacgaa cagcaggagc agcgccgcca gcgacgccac cgcggcccga ttgcgtagga
1436101 acctgcgcac cactagggtg cgccgcgagg cgaattccgt catgacaccc gtaccctcgg
1436161 gtccaaagcc gcgtagatca cgtccgagag caaaccggcc agcaacacga ccgcgccgga
1436221 gaacacggta attgccgcga cgatgttggt gtcctgagtc gagataccgc ggaccatcca
1436281 ttcacccatg ccgtgccagc cgaagatctt ctcgacgaaa accgctccgg tgaccaaccc
1436341 ggccaccccg taggcgaaca gcgtggccat cggtattagc gccgttcgca ggccatgctt
1436401 gagtagggcc cgtcgtcggg tcagcccctt ggcgcgggcg gtgcgaatga aatcctggcc
1436461 gaggacatcc agcatcgcgt tgcgctggta gcggctgaac ccggcggcgg ccgccagcgc
1436521 caacgtcagc gatggcagga tcaaatgctg caaccggtcg cctagccgat cccacacccc
1436581 gccggcaacg ccgggtgacg tctccccggt gtagtcgaaa agctggatgc ccactgccca
1436641 gttgacccgc agggcgccca ggatcaacag gttggccacc acaaacgtcg gtgtgctcaa
1436701 caccagcagc gccagcgtgg tcatgacgcg gtcgctgagc cggtactgcc ggatggcacc
1436761 ccacgccccg atcaccacac cggccaccgt gccgaatacc gatccaacga ccagcagccg
1436821 caggctgact ccgatccggc gccccagttc ggtaccgaca ggctggccgg tgatggtggt
1436881 tccgaagtcg ccacggacgg catgcgatac ccagttggcg tagcgggcca gtatgggtct
1436941 gtccaagccg agatcgtgtg ccttggcatc gataaccgct tgcggtgggc gcggactgcg
1437001 ttgcatcagg ctttccagcg gcgagaacgc cagcgaggtc aggcagtacg tcaaaaacga
1437061 cgccagcgcc agcagcacca ggtagttgag caaccggcgg gccagatagc gcgtcatgcc
1437121 caaccaccgc gtcgcattgg gacagggtag cgagcccggc gatggcgtgc cgccagcgcg
1437181 ccggttgatg gggtcacccg tgatccggat ggttccgctc gggccgattc tgatgcgtga
1437241 aaactgggta accggttgtt aaaattcacc gcggcgtcga tctgagtagc aaagtccaca
1437301 ccgcgatacc cgaggaggcc cgcgtgacgg ttaccgacga ctacctggcc aacaacgtgg
1437361 actacgcgag cggtttcaag ggcccgctac cgatgccgcc gagcaaacac atcgcaatcg
1437421 tggcgtgcat ggacgcccgg ctggacgtct accgcatgct gggcatcaag gagggcgagg
1437481 cacacgtcat ccgcaacgcc ggatgcgtgg tcaccgacga tgtgatccgt tcactggcca
1437541 tcagccagcg gctgctggga acccgcgaaa tcatcctgct gcaccacacc gactgtggga
1437601 tgctgacttt caccgacgac gacttcaagc gcgccatcca ggacgagacc ggcatcagac
1437661 ccacgtggtc gcccgagtcg taccccgacg ccgtcgagga cgtccgtcag tcgctgcgcc
1437721 gcatcgaggt caacccgttc gtcaccaagc acacgtcgct gcgcggcttc gtcttcgatg
1437781 tcgccaccgg caaactcaac gaggtcacgc cctagcagcc cgagccgtca gcctagggcg
1437841 cactggcgca ccggcagccc gccgagatgg ggctgcgttg acagcgatag ggaagcctgg
1437901 ttgcatagat ggcaataacc ataaatatgg tcaatcctac cggatttatc aggtatgagg
1437961 acgtggaaca ggaagccatg accagcgatg tgacggtggg ccccgcaccc ggccagtacc
1438021 aactgagcca tctgcgcttg ctggaggccg aagccatcca cgtcatccgg gaggtggccg
1438081 ccgagttcga gcggccagtg ctgttgttct cggggggcaa ggactccatc gtcatgctgc
1438141 acctggcgct gaaggcgttt cggcccgggc gactgccgtt cccggtcatg cacgtcgaca
1438201 ccggtcacaa cttcgacgaa gttatcgcta cccgagacga gttggtcgcc gcggccgggg
1438261 tgcggctggt ggtggcgtcg gtgcaggacg atatcgatgc cggtcgggtc gtcgagacca
1438321 tcccgtcgcg aaatccgata cagaccgtga cgctgctgcg ggccatccgg gagaaccaat
1438381 tcgacgcggc attcggggga gcccggcgcg acgaggagaa ggcccgcgcc aaggagcggg
1438441 tgttcagctt ccgcgacgag ttcggccagt gggacccgaa ggctcagcgg ccggaactgt
1438501 ggaacctcta caacggacgg caccacaagg gcgagcacat ccgggtcttc ccgctgtcca
1438561 actggaccga attcgacatc tggtcctaca tcggcgccga gcaggtcagg ctgccgtcca
1438621 tctatttcgc ccaccggcgc aaggtgtttc agcgcgacgg catgttgctg gccgtgcacc
1438681 ggcacatgca accgcgagcc gacgagccgg tgttcgaggc cacggtgcga ttccgcaccg
1438741 tcggggatgt tacctgcacc gggtgcgtcg agtcgtcggc atcgacggtc gcggaagtca
1438801 tcgccgaaac tgcggtggcc cgcttgacgg agcgcggggc gaccagggct gacgaccgga
1438861 tctcggaggc tggaatggaa gaccgcaagc ggcagggata cttctgatga cgacgctatt
1438921 gcggctggcg acagcgggtt ccgtcgacga tggcaagtcc acgctgattg ggcggctact
1438981 ctacgactcc aaggctgtga tggaagacca gtgggcgtcg gtggagcaaa cgtccaagga
1439041 ccggggccac gactacaccg acctggctct ggtcaccgac ggcctgcggg ccgagcggga
1439101 acagggcatc accatcgacg ttgcctaccg ctacttcgcc actcccaagc ggaaattcat
1439161 cattgccgac accccgggac acatccaata cacccgcaac atggtgaccg gtgcgtccac
1439221 cgcccaactg gtgatcgtac tggtggatgc ccggcacggc ttgctggagc aatcccgccg
1439281 gcacgccttc ctggcgtcgc tgctgggcat ccgccacctg gtgctcgcgg tcaacaagat
1439341 ggacttgctt ggctgggacc aagagaaatt cgacgcgatt cgagacgaat tccacgcctt
1439401 cgcggcccgc ctcgacgtgc aggacgtcac ctccatccca atctccgcgc tgcacggcga
1439461 caacgtggtg accaaatccg accagacgcc ctggtacgag ggaccgtcgc tgctgtcgca
1439521 tctcgaagac gtctacatcg ccggtgaccg caacatggtc gacgtgcgat tcccggtcca
1439581 gtacgtcatc cggccgcaca ccctcgagca tcaagaccac cgcagctacg cgggcaccgt
1439641 ggccagtggg gtaatgcgtt caggcgacga agttgtcgtg ctgccgatcg gtaagaccac
1439701 ccggatcacc gcgatcgacg gcccgaacgg cccggtggca gaagcgtttc cgccgatggc
1439761 ggtttcggtg cggctcgccg acgacatcga tatctcgcgt ggtgacatga tcgctcgcac
1439821 ccacaaccag cccaggatca cacaagaatt cgacgcgacc gtgtgctgga tggccgacaa
1439881 cgcggtgcta gagcccggcc gcgactacgt tgtcaagcac accacccgaa ccgtccgcgc
1439941 gaggatagcc gggctggatt accggctcga tgtcaacacc ctgcatcgcg acaagaccgc
1440001 aacggcgttg aaactcaacg aactgggccg tgtttcgctg cgcacccagg tgccgttgct
1440061 gcttgacgag tacacccgca acgctagcac cggctcgttc atcctcattg accccgacac
1440121 caacggaacg gtggcggcgg gcatggtgtt acgcgacgtc tcggcccgca cgcctagccc
1440181 gaacacggtg cggcacagat cgctcgtcac tgcgcaagat cggccgccca ggggcaagac
1440241 ggtgtggttt accggactgt ccggctccgg caagtcgtcg gtggccatgc tggttgagcg
1440301 gaagctactc gaaaagggca tctccgctta cgttctggac ggcgacaacc tacggcatgg
1440361 cctcaacgcc gacctgggct tttccatggc cgaccgcgcg gagaacctgc gccggctgtc
1440421 gcatgtggcc acactgctcg ccgattgtgg ccacctggtg ctggtgcccg cgatcagccc
1440481 ccttgctgag caccgtgccc tggctcgtaa agtgcacgct gatgcgggaa tcgacttttt
1440541 cgaggtgttc tgtgacaccc cgctgcagga ctgtgagagg cgtgatccca aagggttgta
1440601 cgccaaagcg cgtgcgggtg agatcacgca cttcaccggg atcgacagcc catatcagcg
1440661 gcccaagaac ccagacctac ggcttacgcc ggatcgcagc atagacgagc aggcgcagga
1440721 ggttatcgac ctgttggagt catcgtctta ggccggcctg gttgctctgc tgtccctggc
1440781 aagcgggtgg cacaatcctg aagcatgcgg atgtcagcta aggcggagta cgcggtgcgg
1440841 gcgatggtcc agctcgccac ggccgccagt ggcaccgtgg tcaagaccga cgatctggct
1440901 gcggcccaag gcataccacc gcagtttctc gtcgatatcc tgaccaacct gcgcaccgac
1440961 cgcctggtgc gaagccaccg cggtcgcgag ggtggttatg aattggcgcg tccgggcacc
1441021 gagatcagca tcgccgacgt attgcgctgc atcgacggac cgctggctag tgtccgcgat
1441081 atcggacttg gcgacctgcc ctactcgggc cccactaccg cgctgaccga cgtttggcgc
1441141 gcgctgcgcg ccagtatgcg gtcggtgctg gaggagacca cgctggctga cgttgccggt
1441201 ggcgcgctgc ccgagcacgt cgcccagctc gccgacgact atcgcgcgca ggagagcacg
1441261 cggcacggcg cctcgcgcca tggtgactag ccgccagagc catcggcagg gcctgcctga
1441321 gccaggtgca accgaaggag tcaacgaatg gtcagcacac atgcggttgt cgcgggggag
1441381 acgctgtcgg cgttggcgtt gcgcttctat ggcgacgcgg aactgtatcg gctgatcgcc
1441441 gccgccagcg ggatcgccga tcccgacgtc gtcaatgtgg ggcagcggct gattatgcct
1441501 gacttcacgc gatacaccgt tgttgccggg gacacgctgt cggcgttggc gttgcgcttc
1441561 tatggcgacg cggaattgaa ttggctgatc gccgccgcca gcgggatcgc cgatcccgac
1441621 gtcgtcaatg tggggcagcg gctgattatg cctgacttca cgcgatacac cgttgttgcc
1441681 ggggacacgc tgtcggcatt ggctgcgcgc ttctatggcg acgcctccct atatccgctt
1441741 atcgccgccg tcaatggcat cgccgatcct ggcgtcatcg acgtcgggca ggtactggtc
1441801 atattcatcg ggcgtagcga cgggttcggc ctaaggatcg tggaccgcaa cgagaacgat
1441861 ccccgcctgt ggtactaccg gttccagacc tccgcgatcg gctggaaccc cggagtcaac
1441921 gtcctgcttc ccgatgacta ccgcaccagc ggacgcacct atcccgtcct ctacctgttc
1441981 cacggcggcg gcaccgacca ggatttccgc acgttcgact ttctgggcat ccgcgacctg
1442041 accgccggaa agccgatcat catcgtgatg cccgacggcg ggcacgcggg ctggtattcc
1442101 aacccggtca gctcgttcgt cggcccacgg aactgggaga cattccacat cgcccagctg
1442161 ctcccctgga tcgaggcgaa cttccgaacc tacgccgaat acgacggccg cgcggtcgcc
1442221 gggttttcga tgggtggctt cggcgcgctg aagtacgcag caaagtacta cggccacttc
1442281 gcgtcggcga gcagccactc cggaccggca agtctgcgcc gcgacttcgg cctggtagtg
1442341 cattgggcaa acctgtcctc ggcggtgctg gatctaggcg gcggcacggt ttacggcgcg
1442401 ccgctctggg accaagctag ggtcagcgcc gacaacccgg tcgagcgtat cgacagctac
1442461 cgcaacaagc ggatcttcct ggtcgccggc accagtccgg acccggccaa ctggttcgac
1442521 agcgtgaacg agacccaggt gctagccggg cagagggagt tccgcgaacg cctcagcaac
1442581 gccggcatcc cgcatgaatc gcacgaggtg cctggcggtc acgtcttccg gcccgacatg
1442641 ttccgtctcg acctcgacgg catcgtcgcc cggctgcgcc ccgcgagcat cggggcggcc
1442701 gcagaacgcg ccgattagcc gcaccacgta taccccgcgg gcaggtggcc gctggccgat
1442761 agcctcatgt gtgtgagcgt gggcgagtca gttgcgcagt cgctgcaaca gtgggatcgc
1442821 aagctgtggg acgtggcgat gctccacgcg tgcaacgccg tcgacgagac cggcaggaag
1442881 cgctatccca cgctgggcgt cggcactcga ttccggacgg cgctacggga ttcactcgac
1442941 atttacggag tgatggccac gcctggcgtc gacctggaaa agactcgctt ccctgtcggg
1443001 gtgagatcgg acttgctgcc ggataagcgc cccgacatcg ccgacgtcct gtatggaatt
1443061 caccggtggt tgcacggtca tgctgacgaa tcctcggttg aattcgaagt aagcccgtac
1443121 gtgaacgcca gtgccgcact ccgcattgcc aatgacggca aaattcagct gccaaagtcc
1443181 gcaatactgg gtttgctggc cgttgccgtg tttgcgccgg agaacaaggg cgaggtcatt
1443241 cccccggact atcagctcag ctggtatgac cacgtgttct tcatcagtgt ttggtggggg
1443301 tggcaagacc atttccgcga aatcgtcaac gtcgaccggg catcgctggt cgccctcgac
1443361 ttcggcgacc tgtggaatgg ctggacgcca gttgggtaat cctggtcgct tgtcgccccg
1443421 ccgggctggg ttagattgcc cggctcctca acccgccgtt tcggcgtgca tcgtcgccgg
1443481 gctagccgtc tcggtcagcg gaccggatcg tcgacgccgc cgcctgcgcg gcggctacct
1443541 ggccgaacgt ggacggcggc ggcgctagag tcccggggcg ctcgacgacc tcggtcgccc
1443601 gcgccgcggc accgagaacc atggcccggt cggattcgtc cgcgaactcg cgctgtgctg
1443661 cccgcacgac cagggcaatt tgggtttgca ccgctacacg gcgcgacggg tcgacgcagt
1443721 tctgggcgac cgcgctgagc agctgcagca gcgcagtgag caccagcggc tcacgcgagc
1443781 cgtagcggcg gatctgggca catccgacgt gcaggtaggt ggcgaagctg gggtacggca
1443841 gccagaagag gagctccccg gcgcggtcgc ggcgcacgtc gtccggcagc gcccgcgatg
1443901 ccagcaccga ctccacggcc gaaagatggt gcacgacttg gatcgccgtg tacgggtcgt
1443961 tgagtgcggg cgatagtgcc cgcagcgcga tatccaccat ctgccgcaat ccgaagcgga
1444021 tgtcctgctg cagggtgcgc tcgaatccga tgtgcacatg acgtaagcag cgttgcggga
1444081 agtcagaccc tggcgcgccc ggcgcggtgc ccctgcgcca gcaccagccg agcaggcccc
1444141 cggcggtgac gtaatcgccg acgaaggtaa ccagcagcgc cgtataccgg ctggctgccg
1444201 ccaattcggc gatgtcgtcg acgtcgacgg tttgtaggta acccgagtgc ggggccaaca
1444261 gcggcaccgc atcagccggg gggctgggcg gtgtctctac ttgtcgatcc gccgtatccg
1444321 attccggata caactggtca accagcccca gcgtgcgcag ccgcaccttg tccatgatcg
1444381 tgtctatctg gatcgagtgc atgaggtggt gcaggaagta gatcagcgcg gcgatgctga
1444441 cgaatgccag cgcgagtgac ccggtgaccg cgactttggg aatgaacgcc ccgccgtcgc
1444501 ggtgctcccc gacggtgtgt agcccaccgg tgctgtaggc gaaggtgcag gcaaagatcg
1444561 ccagcaccac ctggttgggc acatcgcgca ggaaggttcg tagcaaccgc accgagaact
1444621 ggctggaggc gatctgtagg gacagcaccg tcagcgagaa gacgatgccg atggtggtga
1444681 tcatcgtggc cgacaccacg atcagcacgc ctcgggcgtc gcctggggtg ccctgaaaca
1444741 tcagcttgtc gatcagcgtg ccggatttca cgggaatcat cgacaggacc gctcccgacc
1444801 ccagaccgat cgcaacgccg aatgtcggca gcacccagac tgcgccctgt aagtaatcca
1444861 gtatggcttt gcgacggttg agcatgctgg ttgcggtcac cgaataagca tgcacccatc
1444921 cgcgagcact aggcggaact acgtaacact tcgatgcggc agtagaagca tttttccgct
1444981 ctcgcttcgc cgagcgtgca ctcatggcga gtttccggcc gttaacccca agtgatcgct
1445041 gcaacacttg gccagaggtg ttggcgctgc atgggttatc agaaggggtt tcggggtcgg
1445101 ggggatcggg tggccgatgg ggtgcagggg aagttctgga aggcgctcga atcggggtta
1445161 tcgccgacgg tgtgtcctgc tttcctacca aggccgactg caggcggatc cgtggcgtgc
1445221 cggtgttcga cggctatacg cggatggtcg cccggctgat gggatcgctc gccgtgttgc
1445281 ggtcggtgag cattccaaag ggctaccggg acttcggctt tggcagtcta cgtgcggtgg
1445341 cgccgaaaaa ctgcccggac gtgagtggct gaggcggccc aatttcggac taggatttct
1445401 ggccgctgga agtcactgat gacaccgtac gtcacccttg atcgacaagt gcggatgtgg
1445461 ggacccgtcc ggggtcccca catcgtggtg gtcgctgttt agctcgaggt cacgtactgc
1445521 gggcagtagg ccgacgcggc gtcaacggcg aacgtcttgg cgcccttggc gctcagaccg
1445581 gtcgccttgg ccaccgcctt gatgaccgct ttggccgagt gaccctcgtc gagggcgtcg
1445641 cagacggcgt gcgcgtcctt gatggcgcgc gctgcgctcg gcggagtgat cccgtccgcc
1445701 tgcagctgcg cgaggaacgc ttcgtcggtc gagcttgcgc tggcggtccc ggcgaagccg
1445761 agtgcggcca ggcccaaagt agcggcagtc aaggtggtgc caaccatgga ggcggcgaaa
1445821 cggcgagtga acattgatga tctccttgtg ctgatgtcat cggaggttgc gctggtttgc
1445881 gtgccctcag aatcagcacc gggccttgac agattctcaa taaatccttg gcaatatcga
1445941 taccggttcg acggtgtccc gacagtgcaa ggagaacggt ccgccatggc tgtgccggag
1446001 cgcgtcaggc gaatgagaca acacggaacg tgcactcggc gcaccgggtc gccagcaacg
1446061 cggcacgcgg ggcgccctgg ttcttacccc gacgaatttg agagcgagac cacgaagcca
1446121 actatgcggc cgccctcgcg ggtggcgccg atcacattgt tgtagccatg cgtgaggcta
1446181 gatcaaccct tgtgcccccg gcaggattcg aacctgcggc cttctgctcc ggaggcagac
1446241 gctctatccc ctgagctacg ggggcgcacg acgacacgtt gcgccatggg gccccgccag
1446301 agtagcgcat cgcggctacc cactgaccac cgcaacggat tcgaagccca accacctcag
1446361 cccataggat ggacgttcgt gacccccgct gacctggctg agctgctcaa agcgaccgcg
1446421 gccgcggtgc tggccgagcg cggcctcgat gcctccgcgt tgccgcagat ggtcacggtg
1446481 gaacgcccgc gcattcccga gcacggcgac tatgccagta acctggcgat gcagctcgcc
1446541 aagaaagtcg gcaccaaccc gcgtgagctg gccggatggc ttgccgaggc actgacaaag
1446601 gtcgacggta tcgcctcggc ggaggtggcc gggccgggct ttatcaacat gcggctggaa
1446661 accgccgccc aggctaaagt cgttaccagc gttatcgacg ccggccacag ctacggtcac
1446721 tcgctgctgc tggccgggcg caaggtcaac ctggaattcg tctccgccaa ccccaccgga
1446781 ccgatccaca tcggcggtac ccgttgggcc gcggtcggtg acgcgctggg ccgtttgctc
1446841 accacccagg gcgccgacgt ggtccgcgaa tactatttca acgaccacgg cgcccagatc
1446901 gaccgattcg ccaactccct gatcgccgcg gccaagggcg aacccacgcc ccaagacggc
1446961 tacgcgggca gctacatcac caacatcgcc gagcaggtgc tgcagaaggc gcctgacgcg
1447021 ctgagtctgc cagacgcaga gttgcgcgag accttccgcg caatcggcgt cgacttgatg
1447081 ttcgaccaca tcaaacagtc tctgcacgag ttcggtaccg acttcgacgt ctacacccac
1447141 gaagactcga tgcacaccgg cggccgggtc gagaacgcca tcgcccgact ccgcgaaacc
1447201 ggcaacatct acgagaagga cggcgcaacc tggttgcgca ccagcgcatt tggtgacgac
1447261 aaggaccgcg tcgtgatcaa gagcgacggc aaaccggcat atatcgccgg tgatctcgcc
1447321 tactacttgg acaaacgcca acgcggtttt gacttgtgca tctacatgct cggcgccgac
1447381 catcacggct acatcgcccg gctaaaggcc gcggccgccg ccttcggtga cgacccggcc
1447441 accgtcgagg tgctcattgg gcagatggtg aacctggtcc gcgacggcca accggtccgg
1447501 atgagcaaac gtgcaggcac cgtgctcacc ctcgacgacc tggtcgaggc gatcggcgtg
1447561 gacgccgcac gttacagcct gatccgctcc tcggtggaca ccgcgatcga catcgacctg
1447621 gcgctatggt cctcggcgtc gaacgaaaac ccggtctatt acgtgcaata cgcgcatgcc
1447681 cggctctcag cgctggctcg caacgccgcc gaactcgccc tgatcccgga tacaaaccac
1447741 ctcgaactgc ttaaccacga caaggagggc acgctgctgc gcaccctcgg cgaattcccg
1447801 agggtgctcg agaccgcggc ctccctgcgg gaaccgcacc gggtctgccg ctacctggaa
1447861 gacctggccg gcgactatca ccggttctac gactcgtgcc gagtgttgcc gcaaggcgac
1447921 gagcagccca ccgacctgca caccgcgcgc ctagcgttgt gccaggccac ccgtcaggtc
1447981 atcgccaacg ggctggcgat catcggcgtc accgcaccgg agcgaatgtg aacgagctgc
1448041 tgcacttagc gccgaatgtg tggccgcgca atactactcg cgatgaagtc ggtgtggtct
1448101 gcatcgcagg aattccactg acgcagctcg cccaggagta cgggaccccg ctgttcgtca
1448161 tcgacgagga cgactttcgc tcgcgctgcc gagaaaccgc cgcggccttt ggaagtgggg
1448221 cgaacgtgca ctatgccgcc aaggcgttcc tgtgcagcga agtagcccgg tggatcagcg
1448281 aagaagggct ctgtctggac gtttgcaccg gtggggagtt ggcggtcgcg ctgcacgcta
1448341 gctttccgcc cgagcgaatt accttgcacg gcaacaacaa atcggtctca gagttgaccg
1448401 ctgcggtcaa agccggagtc ggccatattg tcgtcgattc gatgaccgag atcgagcgcc
1448461 tcgacgccat cgcgggcgag gccggaatcg tccaggatgt cctggtgcgt ctcaccgtcg
1448521 gtgtcgaggc gcacacccac gagttcatct ccaccgcgca cgaggaccag aaattcgggt
1448581 tatcggtggc cagcggcgcg gccatggcag cggtgcggcg cgttttcgcc actgatcacc
1448641 tgcgcctggt tgggctacac agccacatcg gttcgcagat cttcgacgtg gacggcttcg
1448701 aactcgccgc gcaccgtgtc atcggcctgc tacgcgacgt cgtcggcgag ttcggtcccg
1448761 aaaagacggc acagatcgcg accgtcgatc tcggtggcgg cttgggcatc tcgtatttgc
1448821 cgtccgacga cccaccgccg atagccgagc tcgcggccaa gctgggtacc atcgtgagcg
1448881 acgagtcaac ggccgtgggg ctgccgacgc ccaagctcgt tgtggagccc ggacgcgcca
1448941 tcgccggacc gggcaccatc acgttgtatg aggtcggcac cgttaaggac gtcgatgtca
1449001 gcgccacagc gcatcgacgt tacgtcagtg tcgacggcgg catgagcgac aacatccgca
1449061 ccgcgctcta cggcgcgcag tatgacgtcc ggctggtgtc tcgagtcagc gacgccccgc
1449121 cggtaccggc ccgtctggtc ggaaagcact gcgaaagtgg cgatatcatc gtgcgggaca
1449181 cctgggtgcc cgacgatatt cggcccggcg atctggttgc ggttgccgcc accggcgctt
1449241 actgctattc gctgtcgagt cgttacaaca tggtcggccg tcccgctgtg gtagcggtgc
1449301 acgcgggcaa cgctcgcctg gtcctgcgtc gggagacggt cgacgatttg ctgagtttgg
1449361 aagtgaggtg acccgtgccc ggtgacgaaa agccggtcgg cgtagcggta ctcggtttgg
1449421 gcaacgtcgg cagcgaggtt gtccgcatca tcgagaacag cgccgaggat ctcgcggctc
1449481 gtgtcggtgc cccattggtc ctgcggggca tcggcgtgcg ccgcgtgacg accgatcgcg
1449541 gcgtgccgat cgaattgttg accgacgaca ttgaagagct cgtggcccgc gaggatgtcg
1449601 atatcgtggt ggaagtgatg gggccggtgg aaccgtcgcg caaggcgatc ctgggcgccc
1449661 ttgagcgcgg caagtccgtc gttacggcga acaaggcttt actcgccacc tccaccggcg
1449721 aattggcaca ggccgccgaa agcgcccatg ttgatctgta tttcgaggcg gccgtggcgg
1449781 gcgccattcc ggtcatccgt ccgctcaccc agtcgctggc cggcgacacg gtgctgcgag
1449841 tggccgggat cgtcaacggc accaccaact acatcctctc ggcgatggac agcaccggcg
1449901 ctgactatgc cagcgccctg gccgacgcaa gtgcgctggg ctatgcggag gctgatccca
1449961 ccgcagacgt cgaaggctac gacgccgcgg ccaaggcagc gatcctggca tccattgcct
1450021 tccacacccg ggtgaccgca gacgacgtgt atcgcgaagg catcaccaag gtcactccgg
1450081 ccgacttcgg atccgcgcac gcgctgggtt gcaccatcaa actgctgtcg atctgtgagc
1450141 gcataaccac cgacgaaggt tcgcagcggg tatcggcccg cgtctatccg gccctggtac
1450201 ctctgtcgca tccgcttgcc gcggtcaacg gcgcgttcaa tgccgtggtg gtcgaggccg
1450261 aggccgcggg ccggctgatg ttctacggcc agggcgcggg cggcgcgccg accgcctctg
1450321 cggtgaccgg tgacctagtg atggccgccc gcaaccgggt actcggcagc cgcggccccc
1450381 gtgagtctaa atacgctcaa cttccggtgg caccaatggg tttcattgaa acgcgctatt
1450441 acgtcagcat gaacgtcgcc gacaagccgg gcgtcttgtc cgcggtggcg gcggaattcg
1450501 ccaaacgcga ggtgagcatc gccgaggtgc gccaggaggg cgttgtggac gaaggtggtc
1450561 gacgggtggg agcccgaatc gtggtggtca cgcacctcgc cactgacgcc gcactctcgg
1450621 aaaccgttga tgcactggac gacttggatg tcgtgcaggg tgtgtccagc gtgatacgac
1450681 tggaaggaac cggcttatga ccgtcccgcc gacggccact caccagccgt ggccgggagt
1450741 gattgccgcg taccgtgacc ggctgccggt gggtgacgac tggactccgg tgaccctgct
1450801 cgagggtggt actcccctca tcgcggcaac taatctctcc aagcagacgg gctgcacgat
1450861 ccacctcaaa gtggagggcc tcaaccccac cggctccttc aaggatcgtg gcatgacgat
1450921 ggcggtcacc gatgcccttg cccatggtca gcgggcggtc ttgtgcgcat cgaccggaaa
1450981 tacctcggcg tcggcggcgg cctatgccgc ccgggccggc atcacctgcg cggtgctgat
1451041 accgcagggc aagatcgcga tgggcaagct cgcacaggcg gtcatgcacg gcgccaagat
1451101 catccagatc gacggtaact tcgacgactg cctggaactg gcgcgcaaga tggccgcgga
1451161 cttcccgacg atttcgttgg tcaactcggt aaacccggtg cgcatcgagg gccagaaaac
1451221 ggcagcgttc gagatcgtcg acgtgctagg taccgcgccg gacgtgcatg ctctgccggt
1451281 tggcaacgcc ggcaacatca ccgcgtactg gaagggctac accgagtatc accagctggg
1451341 cctgatcgac aagttgcccc gcatgctggg cactcaggcc gcgggcgcgg cgcccctggt
1451401 gctcggcgaa ccggtgagcc acccggagac catcgcaacc gcgatccgca tcggctcgcc
1451461 ggcgtcgtgg acttcggccg tcgaggcaca gcagcagtcc aagggccgct tcttggccgc
1451521 ctccgacgag gagatactgg ccgcatatca cctggtggct cgtgtcgaag gcgtattcgt
1451581 ggagcccgcg tccgcagcca gcattgcggg tctcctcaaa gcgatcgacg acggctgggt
1451641 ggcgcgtggt tcgacggtgg tgtgcacggt aaccggcaac ggtcttaagg atcccgacac
1451701 cgcgctcaaa gacatgccga gcgtgtctcc ggttcccgtg gacccggtag ccgtcgtcga
1451761 gaagctaggg ctggcctagt ggcgatcgca agcgcggcgg agccgggtgc ggcgggtcgg
1451821 cacggtttgg attgggtggc gatcgcaagc gcggcggagc cgggtgcggc gggtcggcac
1451881 ggtttggatt gggtggcgat cgcaagcgcg gcggagccgg gtgcggcggg tcggcacggt
1451941 ttggattggg tggcgatcgc aagcgcggcg gagccgggtg cggcgggtcg gcacgcatgg
1452001 tgactcaagc attgttgcct tctgggctgg tggccagtgc ggtggtggcg gcgtccagtg
1452061 caaacctggg cccgggcttc gacagtgtcg gtttggcgct gagtctctac gacgagatca
1452121 tcgtcgagac aacagattcc ggcttgacgg tgactgtaga cggcgagggc ggcgaccagg
1452181 tgccgctggg ccccgagcac ctcgtggtcc gcgccgtgca gcacgggtta caggcagcgg
1452241 gggtcagcgc cgccggcctg gcggtgcgct gccgcaacgc catcccgcac tcccgcggcc
1452301 tcggctcctc cgcggcagca gttgtgggcg gtcttgcggc cgttaacggt cttgtcgtac
1452361 aaacggattc gtcaccatcg agcgatgctg agctgattca gttggcttcg gagttcgagg
1452421 gtcatcccga caacgcggcg gccgcggttt tgggtggtgc cgtggtttcg tggactgacc
1452481 acagtggtga ccggcccaac tattcggccg tatcactgcg gcttcatccc gatatccgcc
1452541 tgttcactgc gattcccgag cagcgttcgt cgaccgcgga aacgcgggtg ctattgcccg
1452601 cgcaggttag tcacgacgac gcacggttca atgtcagtcg cgcggcgctg ctggtggttg
1452661 cgctcaccga acggcccgat ctgctgatgg cggccaccga agatctgctt catcagccgc
1452721 aacgtgccgc ggcaatgaca gcctccgcgg aatatcttcg gctgttgcgg cgtcataacg
1452781 tggcagcagc actgtccggg gcaggtcctt cgttgatcgc cctgagtaca gattcagagt
1452841 tgccgaccga cgccgtggag ttcggagccg caaagggatt tgccgttacc gagctgactg
1452901 ttggcgaggc ggttcgctgg agcccgacag taagagttcc cggttaatcc gcaaggttgc
1452961 gggggtttgc ttgcttccgg ccaggaagcg ggctatcctc ggagccgtcc agcaatcgca
1453021 gcatctgcat acgtactgcc ttgccgctag gacagccacc aattcttctt gtggacgagg
1453081 ttcgccgtat tcgccgctga tggcgatcac cgttgcaaag tcgatgattg gcgcactcgg
1453141 cgatttggct gactgcaaca aaaccccgta tgacgtgatc agcgggggaa ggaaaggaaa
1453201 tccgtgaccg atacggacct cattacggct ggcgaaagta ccgacggcaa gccgtcggat
1453261 gccgctgcca cagatccccc agacctcaac gccgacgagc cggccggctc gctggccacc
1453321 atggtgctgc ccgaactgcg tgcgctggct aatcgagccg gcgtgaaggg aacatcgggt
1453381 atgcggaaga acgaactgat cgctgcgatt gaggagatca ggcgacaggc caacggcgcc
1453441 ccagccgttg accggtcggc tcaagagcac gacaagggcg accggccgcc cagttccgag
1453501 gcaccggcca cccaggggga acagaccccg accgaacaga tcgattccca aagccaacag
1453561 gtccgcccgg agcggcgcag cgccacccgt gaagcgggac cctccggctc cggtgagcgt
1453621 gcgggcacag ccgcagacga caccgacaac cgccaaggcg gtcaacagga cgccaagacc
1453681 gaggagcgtg gcaccgacgc gggtggcgac caagggggtg accagcaggc ttcgggcggt
1453741 cagcaggcgc gcggcgacga ggacggagaa gcgcgtcagg gccggcgcgg acgccggttc
1453801 cgcgatcggc ggcgccgcgg tgaacgatcc ggcgacggcg ccgaggctga actgcgtgag
1453861 gacgacgtcg tccagccggt agccggcata ctcgacgtcc tggacaacta cgcgtttgtg
1453921 cgcacctccg gctacctacc cggtccgcac gacgtgtatg tgtcgatgaa catggtgcgc
1453981 aagaacggca tgcgccgtgg tgatgcggtg accggtgcgg tgcgggtgcc caaggaaggg
1454041 gagcaaccca accagcggca gaagttcaac ccgctggtcc gcctggacag catcaacggc
1454101 ggatcggtcg aagacgccaa gaagcggccc gagttcggca aactgacgcc gttgtacccc
1454161 aaccagcggc ttcgtctgga aaccagtacc gagcggctga ccacccgggt catcgacctc
1454221 atcatgccga tcggcaaggg tcaacgcgcg ttgattgtgt cgccgcccaa agcgggcaag
1454281 acaacgatcc tgcaggacat cgccaacgcg atcaccagga acaacccgga atgccacctc
1454341 atggtcgtgc tcgtcgacga gcggcctgag gaggtcaccg atatgcagcg ctcggtcaaa
1454401 ggcgaggtca tcgcttcaac tttcgaccgg ccgccgtcgg accacacgtc ggtcgccgag
1454461 ctggcgatcg aacgcgccaa gcggctggtg gagcaaggca aggacgtcgt ggtgctgctc
1454521 gattcaatca cccggctagg ccgcgcttac aacaacgcgt cgccggcgtc gggccggatc
1454581 ctgtccggtg gtgtcgattc cacggcgttg tacccgccca agcgcttcct gggggccgcg
1454641 cgcaacatcg aagagggcgg gtcgctgacc atcatcgcca ctgcgatggt cgagaccggg
1454701 tccactggtg acacggtcat tttcgaggag ttcaagggca ccggcaacgc cgagctcaag
1454761 ctggaccgca agatcgccga gcggcgggtt ttccctgcgg tcgacgtgaa cccttctgga
1454821 acccgcaagg acgagctact gctgtcgccc gacgagttcg ctattgtgca caagctgcgc
1454881 cgcgtgctat cgggcctgga ttcccaccag gccatcgacc tgctgatgtc gcagctgcgt
1454941 aagacgaaga acaactacga attccttgtt caggtgtcca agaccacgcc agggtccatg
1455001 gacagcgact gatccggcga gacggctcgc cgggaatgtc cgcacgcatc tcggtgtttg
1455061 gggtgatagc ggttgacctg gcataatcga tgctcaacga gttggaaccg gaccaggttc
1455121 tcggcacgcc acgacgggcg gccaccgatc acagagggca gcatgaaatc tgacattcat
1455181 ccggcatatg aggagaccac cgtggtctgc ggatgcggca ataccttcca gacgcgtagc
1455241 accaagccgg gaggtcgtat tgtggttgag gtttgttcgc agtgtcatcc gttctacacc
1455301 ggcaagcaga agatcctcga cagcggcggc cgggtggctc gcttcgagaa gcggtacggc
1455361 aagcgcaagg tcggagctga caaggcggtt tcaaccggca aatagctggc ttaccgacgc
1455421 ccgaactgtg caccagcggt acaggacggg cgtcggttcg cgttagggtc cgcgctcgcg
1455481 ggaagaaggt tgacatgacg cagccagtgc agacgattga cgtgttgctc gccgaacacg
1455541 ccgagctcga gcttgcgctg gcagatcccg cgctgcacag caatccggcc gaggcgcgca
1455601 gagtcgggcg ccggtttgcc cgattggccc cgatcgtcgc aacccaccgc aagctgacgt
1455661 ccgcgcgcga cgacctcgag accgcgcgcg agctggtggc ttccgacgag tcgttcgccg
1455721 ccgaggttgc cgcattggag gctcgggtgg gcgaactgga tgcccaactc actgacatgt
1455781 tggcaccgcg tgacccgcac gatgccgatg acattgtgct ggaagtcaaa tccggcgagg
1455841 ggggcgaaga atccgcgttg ttcgccgccg atttggccag gatgtatatc cgctacgccg
1455901 agcggcacgg ctgggcggtg acggtgttgg acgagaccac ctcggatctg ggtgggtaca
1455961 aggacgcgac gttggcgatt gccagcaaag ccgacacccc cgacggggtg tggtcgcgca
1456021 tgaagttcga gggcggggtg caccgcgtac aacgggtccc agtgacggaa tcccaaggcc
1456081 gcgtgcatac ttcggcggcg ggtgtgctgg tctatccgga gcccgaggaa gtcggccaag
1456141 tgcagatcga cgagtcggat ctgcgtatcg acgttttccg gtcgtccggc aagggcgggc
1456201 agggagtgaa taccaccgac tccgcggtgc gtatcaccca tctgcccact ggaatcgtcg
1456261 tcacctgtca gaacgaacgg tcgcagctgc agaacaagac gcgtgcgttg caggtgctgg
1456321 ccgctcggtt gcaggcaatg gccgaggagc aggcgctggc cgacgcgtcg gccgaccggg
1456381 ctagccaaat ccgcactgtg gaccgtagtg aacgcattcg cacctacaac ttcccggaga
1456441 accggatcac cgaccaccgg atcggttaca agtcacacaa tctcgatcag gtgctggatg
1456501 gcgatcttga cgcgttgttc gacgctctgt ccgccgcgga caagcaatcc cggttgcgac
1456561 aatcatgacc tccgcgccgg cgacgatgcg gtgggggaac ctcccgcttg cgggggagag
1456621 cggcacaatg accctgcgtc aggcgatcga cttggctgct gcgctattgg ccgaagcggg
1456681 ggtcgactcg gcgcgttgcg acgctgagca gttggccgct cacctagcgg gcacagaccg
1456741 cggtaggcta cccctgttcg agccgcccgg cgacgagttc ttcgggcgct atcgcgacat
1456801 cgtcaccgct cgtgcgcggc gggtgccgtt gcagcatctc atcgggactg tgtcgtttgg
1456861 gcccgtggtg ctgcatgtcg gcccgggtgt gtttgtaccg cgtccggaga ccgaagccat
1456921 tttggcctgg gccaccgcgc agtcgctgcc ggcgcggccg ctgattgtcg acgcatgcac
1456981 gggatctggc gcgttggcgg tcgcattggc ccagcaccgg gccaaccttg gactaaaggc
1457041 ccgcatcatc ggcattgacg actccgactg cgcccttgac tatgcccgcc gcaatgcggc
1457101 gggtaccccg gtagagttgg tgcgtgccga cgtcaccacg ccccgcctgc tccccgaact
1457161 cgacggacaa gtcgacctga tggtttccaa cccgccctac atccctgatg ctgctgtttt
1457221 ggaacctgaa gtagcgcaac atgacccgca tcacgcgttg ttcggcggtc ccgacgggat
1457281 gacggtgata tccgcggtcg tcgggcttgc tgggcgctgg ctgcgtcccg gtggcctgtt
1457341 cgccgtcgaa cacgacgaca ccacgtcgtc gtcaactgtc gatttggtca gcagcacaaa
1457401 acttttcgtg gacgtacaag cccggaaaga tctggccgga cggccgaggt ttgtgacggc
1457461 gatgaggtgg gggcacctcc cgcttgcagg ggagaacggc gccattgacc cgcgccagcg
1457521 acgatgcaga gcgaagcgat gaggagaagc ggcgccattg actgagacgt tcgactgcgc
1457581 cgaccccgag cagcgttcgc gtggaatcgt ctctgcggta ggggcaatca aggcgggcca
1457641 actggtggtg atgcctacgg acacggtgta tgggatcggc gccgacgcct tcgacagctc
1457701 cgcggtggcc gcgttgctgt cggcaaaggg gcggggtcgc gatatgccgg taggtgtgct
1457761 ggtcggctct tggcacacga tcgaggggct ggtctactct atgcccgacg gtgcccgcga
1457821 actgattcgc gcattctggc ccggcgcgct cagcctggtg gtcgtgcaag cgccgtcgct
1457881 gcaatgggat cttggcgatg cccatggcac cgtgatgctg cgaatgccgc tgcacccggt
1457941 cgccatcgag ttgttgcgtg aggtgggtcc gatggcggta tccagcgcca acatctcggg
1458001 ccacccaccc ccggtcgacg ccgaacaggc acgctctcaa ctcggcgacc acgtcgcggt
1458061 ctatctcgac gcgggtccat ccgaacagca ggccggctcc acgatcgtcg atctgaccgg
1458121 agccacccca cgcgtcctgc ggccggggcc ggtcagcacc gagcggatcg ccgaggtact
1458181 tggtgtggac gcggccagct tgttcggcta gccgccgaac gtgcacgcac tgcgaagatt
1458241 cggccaattg ttcgcagctg ttgcacgttc ggcgagtgtt cagctctcag gttggtgcag
1458301 tacggtctcg aggtgtccag cgatgtggcc ggcgttgccg gtggcttgct cgccctgtcc
1458361 tatcgcggcg ccggtgtccc gctgcgtgag cttgcgctgg tcgggctgac cgcggcgatc
1458421 atcacctatt ttgcgaccgg tccggtgcgg atgctggcca gtcgcctggg agccgtcgcc
1458481 tacccgcggg agcgagatgt gcacgtcacg cctacccctc ggatgggtgg gttggcgatg
1458541 ttcctgggca ttgtcggcgc cgtctttctt gcctcccagc ttccggcact cacccggggg
1458601 ttcgtctatt ccaccggcat gcccgcggtg ctggtggccg gtgcggtgat catgggcatc
1458661 ggcctgatcg atgatcgttg gggtctggat gcactgacga agttcgccgg ccagatcacg
1458721 gcggcgagcg ttctggtcac catgggtgtc gcctggagtg tcctgtacat cccggtgggt
1458781 ggtgtgggca ccatcgtctt ggaccaggct tcctcgatcc tgcttaccct ggcgctgacc
1458841 gtttcgatcg tcaacgcgat gaactttgtc gacggtctcg acgggctggc cgccggcctg
1458901 ggcctgataa cggcgctggc aatctgcatg ttctcggtgg gtttgcttcg tgaccacggt
1458961 ggtgacgttt tgtactaccc gccggcggtg atttcggtgg tcctggccgg ggcctgcctg
1459021 ggctttctgc cacacaactt ccaccgggcc aagatcttca tgggcgattc cgggtcgatg
1459081 ctgatcggcc tgatgctggc cgccgcttcc accaccgcgg ccgggccgat ctcgcagaac
1459141 gcctacggcg ctcgtgatgt atttgctttg ctgtcgccgt tcctgctggt ggtggcggtc
1459201 atgtttgtgc caatgctcga cctgctgcta gcgatcgtcc gtcgcacccg cgccggccgc
1459261 agcgcgttta gcccggacaa aatgcacctg catcaccggc tgctgcagat cggtcattcc
1459321 catcggcgcg tggtcctgat catctacctg tgggtgggca tcgttgcctt cggcgccgcg
1459381 agctcgatct tctttaaccc gcgcgacacc gcggcggtga tgctgggcgc gatcgtggtc
1459441 gccggcgtcg cgacactgat ccccctgttg cgccgcggcg acgactacta cgacccggac
1459501 ctggactagc ccggagccga gaactacgac aaggagtagt agtggtgtct accttgtggt
1459561 acggtgcggc tagaaccccg aaggagacct cgcgggttgc cggcccccgg cccatcggat
1459621 gcgtatccgg tcgcgccgat tcacgaccga catagggagc taccccttgg gtgattccgg
1459681 tgcgacgact gcgatacgct cggcgggcca ccgatcagtc gatcgggtgg tttccgctcc
1459741 atcagcccgg aattgaggtg ccgcagtgac gacaccagcg caggacgcgc cgttggtgtt
1459801 tccctctgtt gctttccgtc cggttcgcct ttttttcatc aacgttggac tggccgcagt
1459861 ggcgatgttg gtcgccggcg tgttcggtca cctgacggtc gggatgttct tgggtctcgg
1459921 gttgctgctg ggtttgctca atgccctgct ggtgcggcgt tcggccgagt cgatcaccgc
1459981 caaagagcac ccgttaaaac ggtcgatggc cctcaactcg gcatcgcgac tggcgattat
1460041 caccatcctc gggctgatca tcgcctacat tttccggccc gctggattgg gcgtcgtgtt
1460101 cgggctggca ttcttccagg tgctgctggt ggcaacgacg gccctgccgg tcctgaagaa
1460161 gctgcgcact gcgaccgagg aaccggtcgc aacttattct tccaatggcc agaccggggg
1460221 atcggaagga aggagcgcca gcgatgactg agaccatcct ggccgcccaa atcgaggtcg
1460281 gcgagcacca cacggccacc tggctcggta tgacggtcaa caccgacacc gtgttgtcga
1460341 cggcgatcgc cgggttgatc gtgatcgcgt tggcctttta cctgcgcgcc aaagtgactt
1460401 cgacggatgt gccaggcggg gtgcagttgt tttttgaggc gatcaccatt cagatgcgca
1460461 atcaggtcga aagcgccatc gggatgcgga tcgcaccctt cgtgctgccg ctggcggtga
1460521 ccatcttcgt gttcatcctg atctccaact ggctggcagt cctcccggtg cagtacaccg
1460581 ataaacacgg gcacaccacc gagttgctca aatcggcagc agcggacatc aattacgtgc
1460641 tggcgctggc gcttttcgtg ttcgtctgct accacacggc cggtatttgg cggcgcggta
1460701 ttgtcggaca cccgatcaag ttgctgaaag ggcacgtgac gctcctcgcg ccgatcaacc
1460761 ttgtcgaaga agtcgccaag ccaatctcgt tgtcgctccg acttttcggc aacattttcg
1460821 ccggcggcat tctggtcgca ctgatcgcgc tctttccccc ctacatcatg tgggcgccca
1460881 atgcgatctg gaaagcattt gacctgttcg tcggcgcaat ccaggccttc atttttgcgc
1460941 tgctgacaat tttgtacttc agccaagcga tggagctcga agaggaacac cactagtacc
1461001 ggatgctggt aacggctacc agagccatca aggaggataa ggaaatggac cccactatcg
1461061 ctgccggcgc cctcatcggc ggtggactga tcatggccgg tggcgccatc ggcgccggta
1461121 tcggtgacgg tgtcgccggt aacgcgctta tctccggtgt cgcccggcaa cccgaggcgc
1461181 aagggcggct gttcacaccg ttcttcatca ccgtcggttt ggttgaggcg gcatacttca
1461241 tcaacctggc gtttatggcg ctgttcgtct tcgctacacc cgtcaagtaa ttcgacggca
1461301 aatggttgca ataggtagca atgggtgaag tgagcgcgat tgtcctggcc gccagtcagg
1461361 cggcagagga aggcggcgag tccagcaact tcctcattcc caacggcacg tttttcgttg
1461421 tgctggccat cttcctggtg gtgctcgctg tcattggcac tttcgtggtg ccgccgatct
1461481 tgaaggtctt gcgggaacgt gacgctatgg tcgccaaaac gctggccgac aacaagaagt
1461541 cggacgagca gttcgccgcc gcacaggccg attacgacga agccatgacg gaagcccgag
1461601 tccaggcgtc gtccttgcgc gacaatgccc gggcagatgg ccgtaaagtc atcgaggacg
1461661 cacgcgtccg ggccgaacaa caggtggcat cgacgttgca gaccgcccat gagcaattga
1461721 agcgggagag ggacgccgtg gaactcgatc tgcgtgccca cgtgggcacc atgtcggcga
1461781 ctctggccag tcgaattctc ggtgttgacc tcaccgcttc agccgcgacg aggtaaccac
1461841 gaatgtcgac gtttatcgga cagctgttcg ggttcgcggt catcgtttat ctggtgtggc
1461901 gatttatcgt gccgctcgta gggcgtttga tgtccgcacg gcaggacacg gtgcgccaac
1461961 agctggcgga tgcggcggcg gccgccgacc ggctggcgga ggcgagtcaa gctcacacga
1462021 aggcgctgga agacgccaag tcggaagcgc accgtgttgt ggaagaggcc aggacagatg
1462081 ccgaacgcat cgcagaacaa ctagaggccc aggccgacgt cgaggcggag cgcatcaaaa
1462141 tgcagggtgc ccgtcaggtc gacctcatcc gggcacagct gacccgtcag cttcgcctcg
1462201 agctcggtca cgaatcggtg cgccaggcaa gggaattggt acgcaatcac gtggccgatc
1462261 aggcacaaca atcggccacc gtcgaccgct tcctggatca gctcgatgcg atggcgccgg
1462321 ctacggccga tgtcgattac ccactgctgg ccaagatgcg ctcagccagc cggagggcat
1462381 taaccagcct ggtggattgg ttcggcacca tggcccagga cctcgaccat caaggtctga
1462441 ccaccctcgc cggcgagctg gtgtcggtag caagactgct ggaccgcgag gccgtcgtca
1462501 cccgctatct caccgtgcca gccgaagatg cgacgcccag gatccggctg atcgaacggc
1462561 tggtgtccgg caaggtcggc gcgccaacgc tcgaggtgtt gcgcacagcc gtatcgaagc
1462621 gctggtcggc caattccgat ttgatcgatg cgatcgaaca cgtgtcgcgg caggcgctgt
1462681 tagaactcgc cgaacgtgcg ggtcaggtcg acgaggtgga agaccagtta ttccggtttt
1462741 cccgcattct cgacgtgcag ccccggcttg ccatcctgtt gggtgactgt gccgttccgg
1462801 ccgaaggccg agtccggttg ctgcgcaagg tgcttgagcg tgccgacagt accgtcaacc
1462861 cggtcgtggt cgcgctgttg tctcacaccg tcgagctgct gcggggtcag gcagttgagg
1462921 aagcggtgct gttcctggcc gaagttgcgg tggctcgccg cggcgaaatc gtcgcgcagg
1462981 tcggcgcggc ggccgagctc agcgatgctc agcgcactcg cctcaccgaa gtgctgagcc
1463041 gtatctacgg tcaccccgtg accgtgcagc tgcatatcga cgccgcgctg ctgggcggat
1463101 tgtccatcgc ggtcggtgac gaagtgatcg acggtacgct ctcgtctcgt ctagctgcgg
1463161 ccgaggcacg actgcccgac tgaacccgaa ctagtcagca caaaccgaag taggaagacg
1463221 aaaagctatg gctgagttga caatccccgc tgatgacatc cagagcgcaa tcgaagagta
1463281 cgtaagctct ttcaccgccg acaccagtag agaggaagtc ggtaccgtcg tcgatgccgg
1463341 ggacggcatc gcacacgtcg agggtttgcc atcggtgatg acccaagagc tgctcgaatt
1463401 cccgggcgga atcctcggcg tcgccctcaa cctcgacgag cacagcgtcg gcgcggtgat
1463461 cctcggtgac ttcgagaaca tcgaagaagg tcagcaggtc aagcgcaccg gcgaagtctt
1463521 atcggttccg gttggcgacg ggtttttggg gcgggtggtt aacccgctcg gccagccgat
1463581 cgacgggcgc ggagacgtcg actccgatac tcggcgcgcg ctggagctcc aggcgccctc
1463641 ggtggtgcac cggcaaggcg tgaaggagcc gttgcagacc gggatcaagg cgattgacgc
1463701 gatgaccccg atcggccgcg gccagcgcca gctgatcatc ggcgaccgca agaccggcaa
1463761 aaccgccgtc tgcgtcgaca ccatcctcaa ccagcggcag aactgggagt ccggtgatcc
1463821 caagaagcag gtgcgctgtg tatacgtggc catcgggcag aagggaacta ccatcgccgc
1463881 ggtacgccgc acactggaag agggcggtgc gatggactac accaccatcg tcgcggccgc
1463941 ggcgtcggag tccgccggtt tcaaatggct tgcgccgtac accggttcgg cgatcgccca
1464001 gcactggatg tacgagggca agcatgtgct gatcatcttc gacgacctga ctaagcaggc
1464061 cgaggcatac cgggcgatct cgctgctgct gcgccgtccg cccggccgtg aggcctaccc
1464121 cggcgatgtg ttctatctgc attcgcggct tttggagcgc tgcgccaaac tgtccgacga
1464181 tctcggtggc ggctcgctaa cgggtctgcc gatcatcgag accaaggcca acgacatctc
1464241 ggcctacatc ccgaccaacg tcatctcgat caccgacggg caatgtttcc tggaaaccga
1464301 cctgttcaac cagggcgtcc ggccggccat caacgtcggt gtgtcggtgt cccgagtcgg
1464361 cggcgcggcg cagatcaagg ctatgaaaga ggtcgccgga agcctccgct tggacctttc
1464421 gcaataccgc gagctagaag ctttcgccgc tttcgcttct gatttggacg ccgcatcgaa
1464481 ggcgcagttg gagcgcggcg cccggctggt cgagctgctc aagcagccgc aatcccagcc
1464541 catgcccgtt gaggagcaag tggtttcgat cttcctgggc accggcggtc acctggactc
1464601 ggtgcccgtc gaggacgtcc ggcggttcga aaccgaatta ctggaccaca tgcgggcctc
1464661 cgaagaagag attttgactg agatccggga cagccaaaag ctcaccgagg aggccgccga
1464721 caagctcacc gaggtcatca agaacttcaa gaagggcttc gcggccaccg gtggcggctc
1464781 tgtggtgccc gacgaacatg tcgaggccct cgacgaggat aagctcgcca aggaagccgt
1464841 gaaggtcaaa aagccggcgc cgaagaagaa gaaatagcta accatggctg ccacacttcg
1464901 cgaactacgc gggcggatcc gctcggcagg gtcgatcaaa aagatcacca aggcccagga
1464961 gctgattgcg acatcgcgca tcgccagggc gcaggctcgg ctcgagtccg ctcggcccta
1465021 cgcttttgag atcacccgga tgcttaccac cctggccgct gaagccgcac tggaccatcc
1465081 gttgctcgtc gagcgcccgg agccgaaacg agccggcgtg ctggtggtgt cgtccgatcg
1465141 tggtttgtgc ggcgcataca acgccaatat tttccgtcgc tccgaggagc tgttctccct
1465201 gctgagggag gccggaaagc agccggtgct gtatgtggtg ggccgtaagg cgcagaacta
1465261 ctacagtttt cggaactgga acatcaccga gtcgtggatg ggtttctccg agcaacccac
1465321 gtacgagaac gccgccgaga tcgcttcgac cttagtggat gcgttcctgc tcggcaccga
1465381 caacggcgag gatcaacggt ccgacagcgg cgagggcgtc gacgaactgc acatcgttta
1465441 caccgagttc aagtcgatgc tgtcgcaatc ggcggaggct caccggatcg cccccatggt
1465501 ggtggagtac gtcgaggaag acatcggacc gcgcacgctg tactcgttcg agcccgacgc
1465561 gacgatgctg ttcgagtcat tgttgccgcg ctacctgact acccgggtgt acgcggcgct
1465621 gctggagtcc gcggcgtcgg agcttgcctc gcggcaacgt gcgatgaagt cggccaccga
1465681 caacgccgat gacctcatca aggccctgac gctgatggca aaccgcgagc ggcaggccca
1465741 gatcacccag gagattagtg aaatcgtcgg tggcgcaaat gcgctcgccg aagcccgcta
1465801 ggcccaagct aggttagccc cacgaggaag cgaagaagat atgactacca ctgccgaaaa
1465861 gaccgaccgg ccgggaaagc cgggaagctc cgacaccagc ggccgcgtgg tacgggtcac
1465921 tgggcccgtc gtcgacgtcg agtttcctcg cggttccatc cccgagctgt tcaatgcact
1465981 gcacgctgag atcaccttcg agtcgctggc gaaaaccctc accttggagg tggcgcagca
1466041 cctcggcgac aacctggtgc gcaccatctc gctgcagccg accgacggct tggtgcgcgg
1466101 cgtcgaggtg atcgacaccg ggaggtcgat ctcggtgccg gtcggtgagg gtgtgaaggg
1466161 ccacgtcttc aatgcgctgg gagattgcct ggacgagccg ggatatggcg aaaaattcga
1466221 acactggtcg attcaccgca agccgccggc gttcgaggag ctggagcctc ggaccgagat
1466281 gctcgagacc ggtctgaagg tggtcgacct gctgactccg tatgttcgtg gcggcaagat
1466341 cgcactgttc ggcggtgccg gggtgggcaa gacggtgctg attcaggaga tgatcaaccg
1466401 catcgcccgt aacttcggtg gtacgtcggt gttcgccgga gtgggcgagc gcacccgcga
1466461 gggcaacgat ctgtgggtcg agcttgccga agccaacgtg ctcaaggaca ccgcgctggt
1466521 attcggacag atggacgagc cgccgggcac ccgtatgcgt gttgcgctgt ctgcgctgac
1466581 gatggcggag tggttccgtg acgagcaggg tcaagacgta ttgctgttca tcgacaacat
1466641 cttccggttc acccaggctg ggtcggaagt gtcgacgctt ctcggccgga tgccgtcggc
1466701 cgtgggatac cagcccacgc tggccgacga gatgggcgag ctgcaggagc gcatcacctc
1466761 gacgcgggga cgctcgatca cgtcgatgca agccgtctac gtgcccgccg acgactacac
1466821 cgacccagcg ccggcgacca cgttcgccca cctggacgcc acgaccgagc tatcccgtgc
1466881 ggtgttctcc aagggcatct tccccgccgt ggacccgctg gcgtccagct cgaccatcct
1466941 ggaccccagc gttgtcgggg atgagcacta ccgcgtggcc caggaagtca tccggatcct
1467001 gcagcgttac aaggaccttc aggacattat cgcgatcctc ggtatcgacg agttgtcgga
1467061 ggaggacaag cagctggtga accgcgcccg gcgtatcgag cggttcctat cgcagaacat
1467121 gatggcagcc gaacagttca ccggccagcc gggttcgacc gtcccggtga aggagaccat
1467181 tgaagcgttc gaccgcttgt gcaagggcga tttcgatcac gtacccgaac aggccttctt
1467241 cttgatcggt ggccttgatg acctggccaa gaaagccgag agtctcggcg ccaagctgtg
1467301 acgggagttg tggcatggcc gaattgaacg ttgagatcgt cgccgtcgac cggaacatct
1467361 ggtcgggtac ggcgaagttt ctgttcaccc gcaccaccgt cggtgagatc ggcatcctgc
1467421 cccgccacat tccgttggtg gcccaattgg tcgatgacgc catggtgcgg gtcgagcggg
1467481 agggagaaaa ggacctgagg atcgcggtcg acggcgggtt cctgtcggtg accgaggagg
1467541 gcgtcagcat tctcgccgaa tctgccgagt tcgagtcgga gatcgacgag gccgccgcca
1467601 agcaggattc cgaatccgac gatccccgca tcgctgccag gggccgcgcc agattgcgcg
1467661 ccgtcggcgc gatcgactaa cccgccgatg agcgcgccca tgatcggcat ggtcgtgctc
1467721 gtcgttgtcc tggggttggc cgttctcgca ctgagttatc gtctgtggaa gctgcgccag
1467781 gggggaacgg ctgggatcat gcgggacatc cctgcggttg gaggtcacgg ctggcgccac
1467841 ggcgtaatcc gctatcgcgg cggcgaagcc gcgttctacc ggctttctag tctgcgcttg
1467901 tggccggatc gccggctcag tagacggggt gtggagatca tttcccggcg cgcgccccgt
1467961 ggcgacgaat tcgacatcat gaccgacgag attgtcgttg tggaactgtg cgacagcacc
1468021 caggaccgaa gggtaggtta cgagatcgcg ctcgacaggg gcgcgttgac cgcatttctg
1468081 tcgtggttgg agtcccggcc gtcgccgcgc gcgcgccgcc gtagtatgtg acgcactggt
1468141 cagcagacgc aaaagccccc atttcgggct ctactgactg atctgtgggt ggttgtgtcg
1468201 gcctggcagg gtggggcggt ggccggcgag ggtgagcatg gctagggcga tgagggcttg
1468261 tggtgagcgg aatccgaacg cgatccgggt cagtaggcgg atcttggtgt tggtggattc
1468321 gatcaggcct tgggataggc cgtggtcgag ggcggcgtcg atggccaccc ggtggcgttt
1468381 gatgcgggcg gcaagctcga cgaataccgg gatgcgacag cgctgggccc aggagatcca
1468441 ccggtccagg gcctgtttac cttcctcgcc cttgaccgaa aacacatgcc gcaggctctc
1468501 tttgagcagg taggcgcgat acagacgggg atcggtcttg gcgatccagg ccagtttggc
1468561 gctttggcgt tcggtgaggt cctcggggtt cttccacagc gcgtagcggg cgcccttgag
1468621 ccgccgtgcc cgctcgcggc ccggacgtgg tgcggcgttc ttaccgggcc ggccccggcc
1468681 ccacttgggt tcggtgcgcg cgatcgcccg tgcgtcgttc caggctcggc gccgctcgac
1468741 gtcgagcgcc tcggtggccc aggccaccac atgaaacgga tcggcgcatt gaatcgcatc
1468801 cgggcagcgc tcggtgacca cgtcagcgat ccagtccgcg gcatcggccg aaacgtgagt
1468861 aatctgggcg gcccgctcag cgcccagggc atcgaagaac aagcccaggg tggccttgtc
1468921 gtggcccggg gcggcccaca ccaaccggcc gctgtcgtga tcgacgacca ccgtcaggta
1468981 ccggtggtgg cgcttgtagg agatctcatc gataccgatg cggcgcaagt tcgcgaaccg
1469041 gtcaatgcgc ttttcggtgt cggcccagac ccgggccacg atcgccccga cggtgcgcca
1469101 ggcgatccgc atcaactcgc acaccgcggt cttcgaacac gccaccgcca gccaggccac
1469161 cgtgtcatcg aaagcatacg tgtgcccggc atgatgacgc gcccacggca ccgccaccac
1469221 cgtcggccca tgggtggggc agttcacccg cggcgcctcg gcctccaaga acacctcgac
1469281 ggtgccccaa tccagactgc gccattggcg caggcccgca ccgcggtcat accaggacgc
1469341 cttgcgaccg cagcgaccac agcggcgcaa cactgcactt cgtggccgca cccgggcgat
1469401 cacccgcgca ccgtctccgg cgtcatcctc ctcgaattcg atgtcctcaa tcacggtgcg
1469461 cttgtcgaca cccagcagcg cacgaaatag cctcacattg cgcacgtcgt tgtcggctcc
1469521 ttgtgtttct gatccttgac aagccagaaa ccttaagcca caacgacgtg cgcctactca
1469581 ggacacaaac tcacccacgg aagtgtcaga agagcccaaa aaccgtgggt attgggggct
1469641 ttcgcgtctg ctcgcacgcg gaaggtgccg ctagctcgcc gtcctatcac caccgggccg
1469701 ccacagcacg tcaccgtcgg gattggctac ccgcgacagg atgaacagca gatccgacag
1469761 ccggttcagg tatttcgccg gcagtacgct gacgccttcc gggtgagcgt cgaccgcggc
1469821 ccacgcggat cgctcggccc ggcgaacgac ggtgcgagcg acgtgcaaca gcgccgacag
1469881 cggtgaacca ccaggtagta caaaggattt tagtgcaggc aggcccgcgt tgtatgcgtc
1469941 gcaccaccct tcgagccgat cgatatagga ctgtgcgatt cgcagcggag ggtgcttcgg
1470001 gttttccact atcggagtcg acagatccgc accggcatcg aacaagtcgt tctggatctg
1470061 ccgcagcaca tccgtgattt gagtgtccgg gtggcccagc gccagggcgg ccccgatcgc
1470121 ggcgttggcc tcgtcgcaat ccgcgtatgc caccagtcgg gcgtcggttt tggcgacacg
1470181 ggacatatcg ctcaatcccg tcgttccgtc atcgccggtt cgggtataga tgcgggtcag
1470241 gtggactgcc atgagcaaac ggtactcgct gactggcttg gctcactgac aaggcaaaac
1470301 ccctttacta cactgaccgg gtggccgagc gtttcgtcgt gactgggggc aaccggttat
1470361 caggcgaagt ggccgtcggc ggcgccaaga acagcgtgct caagctcatg gctgcgacgt
1470421 tgttggccga gggcaccagc acgatcacca actgtcccga catcctcgat gtgccgctga
1470481 tggcggaggt actgcgtggt ctgggcgcca ccgtcgaact cgacggtgac gtggcccgga
1470541 tcaccgcacc tgacgagccg aagtacgatg ccgacttcgc tgcggtgcgg caattccgcg
1470601 cctcggtctg tgtgctggga ccgctggtcg ggcggtgcaa acgggccagg gtcgcgctgc
1470661 cgggcggtga cgcgatcggg tcgcgtccgt tggatatgca ccaggcgggc ctacggcaat
1470721 tgggtgccca ctgcaacatc gagcacggct gcgtggtagc ccgagcggaa acgttgcgcg
1470781 gtgcggagat tcagttggag ttcccctcgg tgggagccac cgagaacatc ttgatggccg
1470841 ccgtggtggc cgagggagtc accactattc acaatgcggc tcgagaaccc gacgtcgtcg
1470901 acttgtgcac gatgttgaac cagatgggcg cacaggtcga aggtgcgggt tcgccgacaa
1470961 tgaccatcac cggtgtcccg cggctgcatc caaccgagca ccgggtgatc ggagaccgta
1471021 tcgttgccgc cacatggggc atcgctgccg caatgacccg tggtgatata tcagtggcgg
1471081 gcgtagaccc ggcgcatctg cagctggtgc tgcacaaatt gcacgacgcg ggcgcaaccg
1471141 tcacccagac tgacgccagc ttccgggtga cccagtacga gcgtccgaag gctgtcaacg
1471201 ttgcgacctt gccgttcccc gggtttccca cggatctgca gccgatggct atcgctttgg
1471261 cgtcgatcgc cgacggcaca tcgatgatca cggagaacgt gttcgaggcg cggttccgct
1471321 tcgttgaaga gatgatccgg ctcggtgcag acgctcggac cgacgggcac cacgccgtgg
1471381 tgcggggcct cccgcagctg tcgagcgctc cggtgtggtg ttcggacatc cgtgccgggg
1471441 ccggcttggt gctggcgggg ctcgttgccg acggcgacac cgaggtccac gatgtattcc
1471501 acatcgatcg cggatatccg ttgttcgtgg agaacctggt gagtctcggt gccgagatcg
1471561 aacgggtatg ctgttaggcg acggtcacct atggatatct atggatgacc gaacctggtc
1471621 ttgactccat tgccggattt gtattagact ggcagggtcg ccccgaagcg ggcggaaaca
1471681 agcaagcgtg ttgtttgaga actcaatagt gtgtttggtg gtttcacatt tttgttgtta
1471741 tttttggcca tgctcttgat gccccgttgt cgggggcgtg gccgtttgtt ttgtcaggat
1471801 atttctaaat acctttggct cccttttcca aagggagtgt ttgggttttg tttggagagt
1471861 ttgatcctgg ctcaggacga acgctggcgg cgtgcttaac acatgcaagt cgaacggaaa
1471921 ggtctcttcg gagatactcg agtggcgaac gggtgagtaa cacgtgggtg atctgccctg
1471981 cacttcggga taagcctggg aaactgggtc taataccgga taggaccacg ggatgcatgt
1472041 cttgtggtgg aaagcgcttt agcggtgtgg gatgagcccg cggcctatca gcttgttggt
1472101 ggggtgacgg cctaccaagg cgacgacggg tagccggcct gagagggtgt ccggccacac
1472161 tgggactgag atacggccca gactcctacg ggaggcagca gtggggaata ttgcacaatg
1472221 ggcgcaagcc tgatgcagcg acgccgcgtg ggggatgacg gccttcgggt tgtaaacctc
1472281 tttcaccatc gacgaaggtc cgggttctct cggattgacg gtaggtggag aagaagcacc
1472341 ggccaactac gtgccagcag ccgcggtaat acgtagggtg cgagcgttgt ccggaattac
1472401 tgggcgtaaa gagctcgtag gtggtttgtc gcgttgttcg tgaaatctca cggcttaact
1472461 gtgagcgtgc gggcgatacg ggcagactag agtactgcag gggagactgg aattcctggt
1472521 gtagcggtgg aatgcgcaga tatcaggagg aacaccggtg gcgaaggcgg gtctctgggc
1472581 agtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata ccctggtagt
1472641 ccacgccgta aacggtgggt actaggtgtg ggtttccttc cttgggatcc gtgccgtagc
1472701 taacgcatta agtaccccgc ctggggagta cggccgcaag gctaaaactc aaaggaattg
1472761 acgggggccc gcacaagcgg cggagcatgt ggattaattc gatgcaacgc gaagaacctt
1472821 acctgggttt gacatgcaca ggacgcgtct agagataggc gttcccttgt ggcctgtgtg
1472881 caggtggtgc atggctgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg
1472941 agcgcaaccc ttgtctcatg ttgccagcac gtaatggtgg ggactcgtga gagactgccg
1473001 gggtcaactc ggaggaaggt ggggatgacg tcaagtcatc atgcccctta tgtccagggc
1473061 ttcacacatg ctacaatggc cggtacaaag ggctgcgatg ccgcgaggtt aagcgaatcc
1473121 ttaaaagccg gtctcagttc ggatcggggt ctgcaactcg accccgtgaa gtcggagtcg
1473181 ctagtaatcg cagatcagca acgctgcggt gaatacgttc ccgggccttg tacacaccgc
1473241 ccgtcacgtc atgaaagtcg gtaacacccg aagccagtgg cctaaccctc gggagggagc
1473301 tgtcgaaggt gggatcggcg attgggacga agtcgtaaca aggtagccgt accggaaggt
1473361 gcggctggat cacctccttt ctaaggagca ccacgaaaac gccccaactg gtggggcgta
1473421 ggccgtgagg ggttcttgtc tgtagtgggc gagagccggg tgcatgacaa caaagttggc
1473481 caccaacaca ctgttgggtc ctgaggcaac actcggactt gttccaggtg ttgtcccacc
1473541 gccttggtgg tggggtgtgg tgtttgagaa ctggatagtg gttgcgagca tcaatggata
1473601 cgctgccggc tagcggtggc gtgttctttg tgcaatattc tttggttttt gttgtgtttg
1473661 taagtgtcta agggcgcatg gtggatgcct tggcatcgag agccgatgaa ggacgtggga
1473721 ggctgcgata tgcctcgggg agctgtcaac cgagcgtgga tccgaggatt tccgaatggg
1473781 gaaacccagc acgagtgatg tcgtgctacc cgcatctgaa tatatagggt gcgggaggga
1473841 acgcggggaa gtgaaacatc tcagtacccg taggaggaga aaacaattgt gattccgcaa
1473901 gtagtggcga gcgaacgcgg aacaggctaa accgcacgca tgggtaaccg ggtaggggtt
1473961 gtgtgtgcgg ggttgtggga ggatatgtct cagcgctacc cggctgagag gcagtcagaa
1474021 agtgtcgtgg ttagcggaag tggcctggga tggtctgccg tagacggtga gagcccggta
1474081 cgcgaaaacc cggcacctgc ctagtatcaa ttcccgagta gcagcgggcc cgtggaatcc
1474141 gctgtgaatc cgccgggacc acccggtaag cctaaatact cctcgatgac cgatagcgga
1474201 ttagtaccgt gagggaatgg tgaaaagtac cccgggaggg gagtgaaaga gtacctgaaa
1474261 ccgtgtgcct acaatccgtc agagcctcct tttcctctcc ggaggagggt ggtgatggcg
1474321 tgccttttga agaatgagcc tgcgagtcag ggacatgtcg caaggttaac ccgtgtgggg
1474381 tagccgcagc gaaagcgagt ctgaataggg cgacccacac gcgcatacgc gcgtgtgaat
1474441 agtggcgtgt tctggacccg aagcggagtg atctacccat ggccagggtg aagcgcgggt
1474501 aagaccgcgt ggaggcccga acccacttag gttgaagact gaggggatga gctgtgggta
1474561 ggggtgaaag gccaatcaaa ctccgtgata gctggttctc cccgaaatgc atttaggtgc
1474621 agcgttgcgt ggttcaccgc ggaggtagag ctactggatg gccgatgggc cctactaggt
1474681 tactgacgtc agccaaactc cgaatgccgt ggtgtaaagc gtggcagtga gacggcgggg
1474741 gataagctcc gtacgtcgaa agggaaacag cccagatcgc cggctaaggc ccccaagcgt
1474801 gtgctaagtg ggaaaggatg tgcagtcgca aagacaacca ggaggttggc ttagaagcag
1474861 ccacccttga aagagtgcgt aatagctcac tggtcaagtg attgtgcgcc gataatgtag
1474921 cggggctcaa gcacaccgcc gaagccgcgg cacatccacc ttgtggtggg tgtgggtagg
1474981 ggagcgtccc tcattcagcg aagccaccgg gtgaccggtg gtggagggtg ggggagtgag
1475041 aatgcaggca tgagtagcga caaggcaagt gagaaccttg cccgccgaaa gaccaagggt
1475101 tcctgggcca ggccagtccg cccagggtga gtcgggacct aaggcgaggc cgacaggcgt
1475161 agtcgatgga caacgggttg atattcccgt acccgtgtgt gggcgcccgt gacgaatcag
1475221 cggtactaac cacccaaaac cggatcgatc actccccttc gggggtgtgg agttctgggg
1475281 ctgcgtggga acttcgctgg tagtagtcaa gcgaaggggt gacgcaggaa ggtagccgta
1475341 ccagtcagtg gtaacactgg ggcaagccgg tagggagagc gataggcaaa tccgtcgctc
1475401 actaatcctg agaggtgacg catagccggt tgaggcgaat tcggtgatcc tctgctgcca
1475461 agaaaagcct ctagcgagca cacacacggc ccgtacccca aaccgacaca ggtggtcagg
1475521 tagagcatac caaggcgtac gagataacta tggttaagga actcggcaaa atgcccccgt
1475581 aacttcggga gaagggggac cggaatatcg tgaacaccct tgcggtggga gcgggatccg
1475641 gtcgcagaaa ccagtgagga gcgactgttt actaaaaaca caggtccgtg cgaagtcgca
1475701 agacgatgta tacggactga cgcctgcccg gtgctggaag gttaagagga cccgttaacc
1475761 cgcaagggtg aagcggagaa tttaagcccc agtaaacggc ggtggtaact ataaccatcc
1475821 taaggtagcg aaattccttg tcgggtaagt tccgacctgc acgaatggcg taacgacttc
1475881 tcaactgtct caaccataga ctcggcgaaa ttgcactacg agtaaagatg ctcgttacgc
1475941 gcggcaggac gaaaagaccc cgggaccttc actacaactt ggtattgatg ttcggtacgg
1476001 tttgtgtagg ataggtggga gactgtgaaa cctcgacgcc agttggggcg gagtcgttgt
1476061 tgaaatacca ctctgatcgt attgggcatc taacctcgaa ccctgaatcg ggtttaggga
1476121 cagtgcctgg cgggtagttt aactggggcg gttgcctcct aaaatgtaac ggaggcgccc
1476181 aaaggttccc tcaacctgga cggcaatcag gtggcgagtg taaatgcaca agggagcttg
1476241 actgcgagac ttacaagtca agcagggacg aaagtcggga ttagtgatcc ggcacccccg
1476301 agtggaaggg gtgtcgctca acggataaaa ggtaccccgg ggataacagg ctgatcttcc
1476361 ccaagagtcc atatcgacgg gatggtttgg cacctcgatg tcggctcgtc gcatcctggg
1476421 gctggagcag gtcccaaggg ttgggctgtt cgcccattaa agcggcacgc gagctgggtt
1476481 tagaacgtcg tgagacagtt cggtctctat ccgccgcgcg cgtcagaaac ttgaggaaac
1476541 ctgtccctag tacgagagga ccgggacgga cgaacctctg gtgcaccagt tgtcccgcca
1476601 ggggcaccgc tggatagcca cgttcggtca ggataaccgc tgaaagcatc taagcgggaa
1476661 accttctcca agatcaggtt tctcacccac ttggtgggat aaggcccccc gcagaacacg
1476721 ggttcaatag gtcagacctg gaagctcagt aatgggtgta gggaactggt gctaaccggc
1476781 cgaaaactta caacaccctc ccttttggaa aagggaggca aaaacaaact cgcaaccaca
1476841 tccgttcacg gcgctagccg tgcgtccaca ccccccacca gaacaaattt gcatagagtt
1476901 acggcggcca cagcggcagg gaaacgcccg gtcccattcc gaacccggaa gctaagcctg
1476961 ccagcgccga tgatactgcc cctccgggtg gaaaagtagg acaccgccga acatacaaaa
1477021 acacccccgg taacggtggt gtttttgtat gtttatatcg actcagccgc tcgcgagcgg
1477081 gcgaattatg gcttcgattt tcgcaatgac gataccctcg cgggcggggg cgctcagtcg
1477141 aagagcgtca agtctgcggg cgcccggctt ttctccaact cgagcagagc tcgtttccgg
1477201 ttgattccac cgccgtaccc ggtgagcttt ccgctggcgc cgatcacgcg gtggcacggg
1477261 acgatgatgg cgatgggatt gtggccgttg gccaatccca cggcgcgtgc ggcgccgggg
1477321 gcgccgatct ggtcggcgat ttccccgtag gaccgggttt ccccgtacgg gattgtcagc
1477381 aatgctttcc atactcgttg ctgaaagtcg gttccccgga ggtcaagttc cacatcgaat
1477441 tcggtgagct cgccggcgaa ataagcgttg agttggtcga cagcgccaga aaatgcgccg
1477501 gggtcgggtg tccagtgtgt gcggcttggc tcatacgtct gctcgagcat ccgcaggttc
1477561 gtcaacaccg agccatgccc ggccagggtt aatggcccga tggggctatc gatggtgcgg
1477621 tagtgaatca tgcgatcttc tcctgcggtg gccattggtt taccggatgt tccagggtgg
1477681 tccacaggtg ctgggtggca taggagcgcc aggggcgcca gcgagcgctg tgcaccgtca
1477741 gggctcgtcg ttgtgcaggc aggcccagct ttttggcggc cagccgcagg ccgagatcac
1477801 tggccggaaa ggcgtccggg tcaccgaggc cgcgcatggc gatgacctcc gcggtccagg
1477861 ggcccactcc gggcagcgct agcaactgcc cgcgggcgcg ttgccagtca catccggcgt
1477921 ccaggaccag acttttgtcg gcaaggctgg cgacgagcgc gtttatggtc ctttgacgcg
1477981 ccttggggac ggccagatgg ccgggatcga tctcagcgag ctgctcgatc gacgggaagg
1478041 tgtgggtcaa agcgccgtgg cgatcgtgga ccggccgtcc gtaggcggcg accagtcggc
1478101 ccgcgtgagt gcttgcggcc ttcgtcgata cctgttgggc gaggaccgcc cgcacggcga
1478161 attctgcctc gtcgactgtg cggggaatgc gttgcccggg tgccttgccc accactgcgc
1478221 gcagatccgg atcggcgccc agcgcctcga cgatcgcttc gggatcggcg tcgaggtcca
1478281 gcagccgtcg gcaacgtgca gtggccgtca tcaggtcgcg gaaatcatcg agcacaagca
1478341 ggcagcgcac atgatcgggt gccggcgtca ggctgacgat gccgttgccc catgggagcc
1478401 gtagcgtgcg tcggtacgca ccatcgcgga cctcttcgca acccggcacc gcggtggcgg
1478461 ccagatggcc gaaaacaccc tcgaaggcga atggtgcacg gacgggtagc cgcagcgaca
1478521 ccgtgcccgc tgatgcggtg gcagactcga atcgggcggc cgcgcgcgca cgcaatgccg
1478581 tcggtgtgcc gtcgcacgcc aggcgaacgg tgtcgttgaa ctgacggatg ctggaaaacc
1478641 cggcggcgaa tgcgacatcg ccgaacggca ggttcgtggt ctcgatcagc acccgggcgg
1478701 tctgcatgcg ttgggcgcgg gccaacgcga gcggaccggc gccgaccacg gcctgcaaca
1478761 gccgctccag ctggcgaatg gtgtaaccga gctgggccgc gaggccgctg acaccgtcgc
1478821 ggtccaccgt tccgtcggca atcagccgca tcgcccgcgc cacgacgtca ctacgcacat
1478881 tccattccgg agacccaggc gaggcgtcgg ggcggcaccg tttgcaggcc cggaatccct
1478941 ccccctgagc ggccgccgca gtcggcagga accggacatt gcgcgcgaac ggtggccgga
1479001 cggggcaact cggccggcag tagacaccgg tggtcaaaac cgcgacgacg aaccagccgt
1479061 cgaaccgggc gtctttggac tggatcgccc ggtagcagcg ttcgaagtcg tcgtgcaccc
1479121 ttcaacaatt acacccgccc accgacatga ctggcggaaa aacgacattg tgatggggtc
1479181 gtcgtgggtt cgggcaggtt acctacgcgg cttggtcagc ccgaccggct tggccagccg
1479241 gaccggttgg tcgtgcccac gaagtttcac atgcctaccc aaagaccaac gggcgcgctc
1479301 ctcttcgctt gcggcgtcca cggcctgtgc cgaagccagc aacttgccgg gacgcgattt
1479361 ggccagttcg cacaatcggg ccgcctcgtt gaccggctcc ccgatcacgg tgtactcgaa
1479421 ccgttctcgg gcacccacgt tgccggcaat gacctgcccc gccgccacgc cgatcccggc
1479481 ctggcactcg ggcatttcgt tgaccagccg atcggctatc gcccgcgcgg cggccagtgc
1479541 cttgtcttcg ggacagggaa gccggttcgg ggcgccgaag atggttagcg acgcgtcccc
1479601 ctcgaacttg ttgaccaatc cgtggtggcg gtcgacctcg tcgacgacaa tcgcgaagaa
1479661 cttgttgagc agcttgacga cgtcggccgg cggccggctg gtcaccaatt gcgtcgagcc
1479721 gacgatgtcg atgaacacga cggcgacgtg gcgttcttcg ccgcccagtt tcgaacgttc
1479781 acgctcggcg gcggcggcga cttcgcgtcc gacgtggcgg ccgaacagat cgcgcactcg
1479841 ttcgcgctcc cgcagtccgg cgaccatcgc gttgaaacca cgctgcagct cgccgagttc
1479901 ggtgccgtcg aagaccacca ggttggtccg tagctcgccc cgctcgacgc gccgcagcgc
1479961 cgcacgcacc acccgcaccg gggtcgccgt cagccaggcc aggatccaca tcaggatgaa
1480021 cccgaacacc aatgtgacca tcgagatgat cagcacgccc gtcgcgaact gcatccgagt
1480081 gagattgagc agcaccattt cgaacatcgc catcagggcg atgccgacga cgggtactcc
1480141 cgaaccgagc agccacacca ccatggtccg gcccaggatt cccggcgcca accggcgtgg
1480201 cggcggcccg gcctcgagcg cctgggcggc gaacgggcgc aatgcgaact cggtatgcag
1480261 ataggttgcg gttgcgacca atacgccgca aaagctgacc gcgaacagga atcgcgggat
1480321 gaacgcgttg ttgatcaggc cgtagagtgt cgtcaagagc gccgtgccaa caccccagaa
1480381 catgaggtgg cccacggcga ctcgccaggg ggccaggaag gtgcggcgct cctcctcacg
1480441 agtcggtttc cgtccttcga tcgcccagcg cagggcttgc acggtctgcc tggtcagtgc
1480501 gtagctaccc aaagcgaggg ctagcaggac atagcccggt accaccccga acgtgagcca
1480561 ccgtggcgtg tcgcgaacga tgctcggttc ggggatggcg atcgtcacca atagcagggc
1480621 aaccccgatg ccgagcaggt tcgcggtcac gaccagcgcg gtcagcatga cctggatccg
1480681 tacccgtcgg cgccgttggc tttccgaaac ccgcccaagc agccaggagc cgtacgcggg
1480741 agtttctggc agccggccgc tctgccgggt caccgtctcc agcacccgac ccaagcgttg
1480801 cgccgtgctc ttcttggccg acattgtggc gtcagactag tttgtcgaag agtcgggtgc
1480861 gaccggttgg cgcgctcgtg ttgtttgccc ggcttaggtg ggcacggcca gccgagtcgg
1480921 ctgctcatgt ccgcgcagcg tcaccgtctc gcccaaagac caatgggcac gttcggtttc
1480981 gctggcagcg tgcagtgtgt ccgaggatgc tagcaatcgc gcggggtgtg atttggccag
1481041 ttcgcacaat cgggccgcct ggttgaccgg cttgccgacc actgtgtatt cgaatctttg
1481101 cttggcgccg acattgccgg cgacgatctg gcctgccgcc accccgatgc cggcttggac
1481161 ctcgggcatc tcgttggcca gccgatcggc tatggcccgg gcggcggcca gcgcggcgtc
1481221 ttcgggacgg tcgaggcggt tcggggctcc gaagatggcc agggcggcgt cgcctgcgaa
1481281 cttgttgatc agtccgtggt gacggtcgac ctcgttgacg acgatcgcga aaaaccggtt
1481341 gaggagcttg accacgtggg cggcaggttg gttgtccacc agctgggtgg agccgacgat
1481401 gtcgacgaag acgacggcgg cgtggcggtc ttcgccgcct agctgtggtc gttcacgctc
1481461 ggcggcggcg gcgacttcgc gtccgacgtg gcggccgaaa aggtcgcgca cgcgttcgcg
1481521 ctcgcgcagg ccgttgacca tcgcgttgaa accacgctgc agctcaccga gttcggtgcc
1481581 gtcgaacacc accagatccc ctcgcagatc cccctgctcg acacgcttga gcgcagcgcg
1481641 caccactcgc accggcgccg ccgtcagcca agcaagaatc cacatcacga gaaacccgaa
1481701 gatcaacgtg gttatcgaca ggatcaacac cgccgacgcg agctgcgttt cggtcagatt
1481761 gtgcaccaat aggacgtaga gcgctgtcgt ggcgatgccg gtcacaggca cgcctgaacc
1481821 tagcgaccac accgtcatcg ttcggcccat gatgcccggt gcaaaccgtc gtggcggtcg
1481881 tcccgcttcg agtgctttag cggctacggg tcgcagcgcg aactcggtga acaagtagca
1481941 attggtggct accaaaacgc cgcagatagt caccgagaac aaaattatgg tgacgaatac
1482001 gcggttggcc agcccgtaga gcgtggccaa caacgccccg ccgatatccc acagaatgag
1482061 gtggacggct gccactcgaa acgggagcag caaggtgttg cgcccgtcgg cctggctcgg
1482121 cgcgcgttcc tcgatcgccc accgtatgga cgctctgacg attcgcgtgg ttatccagta
1482181 ggtgccgatg gccagtgcga gcgtcgcata ggccggtgcg accccgaagg tgacccacca
1482241 tggggcgtcg gtgtagatgc taggcaccgg aaaagcgaag gtcaccacta gcagcgcgac
1482301 cacgatcccg gtcaggttcg ccgtcatgat atagacggtc acgatgcgct tgatgcgtac
1482361 ccagcgacgc gacgggcttt ctgacacccg cccaagcaac caggagccat acgccggggt
1482421 ctcgggcagc tggccgcact gacgggtcat cgtctcgagt gcctggccca ggcgttgcgc
1482481 catggtcttt ttcgccggca tggtggcgtc agcctaatct gtcggatgcg ccccacggta
1482541 aatcgtgtgg gtctggtgat cgcccagtgc accgccgact atgtcggccg actgagcagg
1482601 catctgcagc tgttgaactg gcgacgtcag ccggatgggc tggtcgtgcc cgcgaagtgt
1482661 cacggtctcg cctaaagacc aacgggcaca ttcgttttca ctggcaccgc gcaacgtttg
1482721 cgacgacgcc aacaatcggc tcgggtatga ttttgccagt tcgcacagtc gtgcagcctc
1482781 gttgaccggt tcgccgatca cggtgtattc gaaccgttcg tgggcgccga cattgccggc
1482841 gacaacctga cctgccgcta ccccgatgcc ggcttggcac tccggcattt cgctggctag
1482901 ccggtcggcg atggctcgtg cggtggccag cgcggcatct tcgggatggc tcaggcggtt
1482961 gggggccccg aagactgcca gcgaggcgtc tccctgaaac ttgttgacaa gtccacggtg
1483021 atggttcact tcatcgacga ttaccgtgaa gaaccggttg agtagcatca cgacctctgc
1483081 cgcaggccgg ctggtgacca attgagttga accgacgatg tcgacgaaga cgacggcgac
1483141 atggcgctct tcgccgccca gttttggtcg ctcgcgttcg gctgctgcgg cgacctcgcg
1483201 accgacgtgg cggccgaaga gatcgcgtac gcgttcgcgc tcgcgcaggc cctcgaccat
1483261 tctgttgaaa ccacgctgta gctcaccgag ttcggtcccg tcgaatacga ccagatcgcc
1483321 gcttagatcg ccctgctcta cgcggttgag cgcctcgcgg accacgcgca caggcgtggc
1483381 cgtcagccaa gcgagaatcc acatcaggat gaatccgaag atcaacagtg gtgcccacag
1483441 gatcagcact gtgatcatga attgatcatt ggagagttcc caaaacgtat cgtcgaagat
1483501 ggcggtgagg gcgacaccga cattgggtac gcctgaacag agcagccaca ccagcatggt
1483561 tcggcccacg atgcctcgca ccagcgatcg tggtgttgct cccacttcga gcgcctgggc
1483621 ggccatcggg cgaagcgcaa actcggttaa cagatagcag ctggtggctg cgacaacgcc
1483681 gatgacgccc atcgaaaaca ggaaccgcgg gataaacaac cggttggcca ggccgtagat
1483741 tatcgtccac aacgctgcgg cggcgcccca caggaaaaga actgccaacg ccactcgcag
1483801 tgggactagg aaagcgctgc gcgcctcatc atggctgggg gtgcgttcct cgattgccca
1483861 ccgcaacgct cgagccgttt gcctggtgag ccagtaggtg cccagtatga aggcgagcac
1483921 gcagtatccc ggaacgatcc cgaacgacac ccaatgcggg gcgtccaaaa tcacgcttgg
1483981 tttcggaaag gcgaccgtca gtagcatggc accgacaatg agcccgatca cgttcgtgac
1484041 caaaatggcg acggtcagca tgccctggat acgtacccgc cgcatccgtg ggctctccga
1484101 cacgcgccca agcagccatg agccgtatgc gggcgtctct ggccgtcgtc cagtgcgcgg
1484161 gctgagagtc tcgacggccc ctggcaagtg tcgagtggtg gccttctcgg atggcatggt
1484221 gacgtcagcg tagtgtgtcg gtcacgctct aaggaacaac gtcgttgcgc gctctaaggt
1484281 gagtcgggtg cgtctagtca tcgcccagtg cactgtcgac tacatcggcc ggctcaccgc
1484341 gcatctgccg tccgcgcgcc ggctgttgct gttcaaggcc gacggatcgg tcagcgtaca
1484401 tgctgacgac cgcgcctaca agccgttgaa ctggatgagt ccgccgtgct ggttgaccga
1484461 agagtccggc ggccaggcgc cagtgtgggt ggtcgagaac aaggccggcg agcagctgcg
1484521 catcactatc gaaggaatcg agcacgacag tagccacgag ctgggcgtgg accccgggct
1484581 ggtcaaggac ggcgtcgagg cccacttgca ggcgttgctc gccgagcaca tccaattgct
1484641 gggcgaaggg tacacgctgg tccgccgcga gtacatgacc gcgatcggac ccgtcgacct
1484701 gctgtgcagc gacgaacgag gtggctcggt cgcggtggaa atcaagcggc gtggcgagat
1484761 cgacggcgtg gagcagctga cccgctacct cgagttgctc aaccgcgaca gtgtgctcgc
1484821 gccggtcaag ggggtgtttg ccgctcaaca gatcaagccg caggctcgga ttctggccac
1484881 cgaccgcggg atccgttgtt tgacattgga ttacgacaca atgcgcggga tggatagcgg
1484941 cgagtaccgg ctgttctgag ttgcgcgatt aaactgatgc gatggctcgg cgccgcaaac
1485001 cgctgcaccg gcagcggccg gaaccgccgt cgtgggccct gcgccgagtg gaagcggggc
1485061 ccgatggcca cgagtatgaa gtacgaccgg tcgctgcggc ccgcgccgtc aagacctatc
1485121 gctgtccggg gtgtgatcac gaaatccgtt ccggtactgc acatgtggta gtgtggccga
1485181 ctgacttgcc gcaagccggc gtcgatgacc ggcgtcactg gcacaccccg tgctgggcga
1485241 accgagcaac ccgcggtccg actcgaaaat ggacctaggc ttttggcggc tggtgcgccc
1485301 tgctggtgcg ccttaggggg ccggctccac caactcgatc agaaccccgc cggcgtcttt
1485361 cgggtggatg aagttgatcc gtgagttcgc ggtgccacgc ctggccgtct cgtagaccag
1485421 ccggacgccc tgggagcgca gccgccgaca catggcgtca agatcgctga cccggcacgc
1485481 cagctgttgg atgcctggcc cgcgcttgtc caggaacttc gctatcaccg aggattcgtc
1485541 gagcggggcc atcaactgga tttgcgccgc ggagcccggc accgccagca gtgcctcgcg
1485601 gatgccctga tcgtcgttga tttcctcgtg gaccaggatc atgccaaggt ggtcgtgata
1485661 ccactcgatg gcaacgtcca ggtcggcgac cgcaataccg acgtgatcga gtccagttac
1485721 caacgaggta gccagcatgt gacgggcgtg gacttgatcg gtcgtcatca cacaacggta
1485781 acctgaaggg aaagaatctg cttctccggg tcggtcagat cggctttcgg gtgcgctgag
1485841 gaggtagtca taacgacatc ggtgattgtt gctggcgcgc gtacacccat cggcaagttg
1485901 atgggctccc tgaaggattt cagcgccagc gagctgggtg ccatcgccat taagggcgcc
1485961 ctggagaagg ccaacgtgcc ggcgtccttg gtcgagtacg tgatcatggg ccaggtgttg
1486021 accgcgggtg ccgggcaaat gcccgcacgg caggcggcag tggcggccgg catcggttgg
1486081 gatgtccctg cgctgacgat caacaagatg tgcctgtccg gcatcgacgc aatcgcgctg
1486141 gctgatcaac tcattcgggc cagagagttc gacgtggtgg tggccggcgg tcaggagtcg
1486201 atgacgaagg cgccccacct gttgatgaat agccggtcgg gttacaagta cggcgacgtt
1486261 acggttttgg accacatggc ctacgacggt ctgcacgacg tgttcaccga tcagccgatg
1486321 ggcgcgctca ccgagcaacg caacgacgtc gacatgttca cccgctccga acaggacgag
1486381 tacgcggctg cgtcccacca aaaggcggcc gcggcatgga aggacggcgt attcgccgac
1486441 gaggtgatcc cggtgaacat cccgcagcgc acgggcgatc cactgcagtt caccgaggac
1486501 gaggggatcc gcgccaacac caccgccgcc gcgctggccg gtctgaagcc ggcgttccgt
1486561 ggcgacggca ccatcaccgc cgggtcggcg tcacagatct ccgacggtgc ggccgcggtg
1486621 gtggtcatga accaggaaaa ggcccaggaa ctggggctga cctggctagc cgagatcggc
1486681 gcccacggtg tggtggccgg gccggattcc acactgcaat cgcagccggc caacgcgatc
1486741 aacaaggcgc tggatcgcga gggcatctcg gtggaccagc tcgacgtggt ggagatcaac
1486801 gaggcgttcg ctgcggtggc attggcctcg atacgcgaac tcgggctgaa cccccagatc
1486861 gtcaacgtca acggtggtgc gattgccgtc gggcatcccc tcggcatgtc agggacgcga
1486921 atcacgctac atgcggcgct gcagttggca cgccggggat cgggcgtcgg ggttgccgca
1486981 ttgtgcgggg ctggcgggca gggcgacgca ctgatattgc gggccggata gcggttgagg
1487041 ggtcggtggc ggccagtgtg atcttggtca taccaaccga tcgcggtatg tcggctcctg
1487101 ccgcagggtc ggcgccaccg ggtggatcga tgaccgcagc ggcatgacag acttgacggc
1487161 gtgacgcgtc cgcgaccccc gctcgggccg gccatggccg gtgctgttga cctctccggc
1487221 atcaaacaac gtgcccagca aaacgctgcg gcgagcacgg atgccgaccg ggcactgtcg
1487281 acgccgtccg gtgtgaccga gatcaccgag gcgaacttcg aggacgaggt gatcgtccgg
1487341 tccgacgaag tgccggtggt ggtgttgctg tggtcacccc gcagcgaggt atgcgtcgac
1487401 ttgcttgaca cgctgtccgg cttggccgct gccgctaagg gcaagtggtc gctggcgtcg
1487461 gttaacgttg acgtcgcacc cagggtggca cagatattcg gcgtccaagc ggttccgacc
1487521 gtggtggcct tggctgcggg acagccgatc tcgagcttcc agggcctcca gcccgcggac
1487581 caactgagtc gctgggtgga ttccctgttg tctgcgacag ccggaaagct caagggcgca
1487641 gcgagttccg aggagtccac cgaagtcgat ccagcggtgg cacaggcgcg ccagcagctc
1487701 gaggatggcg actttgttgc cgcgcgcaag tcatatcagg cgattttgga tgccaaccca
1487761 ggaagcgtcg aagccaaggc ggccatccgc cagatcgaat tcctcatccg cgcaaccgca
1487821 caacggcccg acgccgtctc ggtcgccgac agcttgtcgg atgacatcga cgccgcgttt
1487881 gcggcagccg acgtgcaagt cctcaaccag gatgtgagtg cggccttcga gcgcctgatc
1487941 gcgttggtgc gtcggacatc tggagaagag cgcacccggg tgcgcacccg gctgatcgag
1488001 ctgttcgagc tgttcgaccc cgccgatccc gaggtcgtgg ccggtcggcg caacctcgcc
1488061 aacgcgctgt actgaggccg gctggcgagc agacgcagaa tcgcctaaac ccgcacgggt
1488121 ttaggcgatt ctgcgtctgc tcgcgctggg cggctacgac aacccgggtg atccgttcag
1488181 gccgagcagc ccggcggtgc cgccggcgcc acccttaccc ggcgcactgc cgactccgcc
1488241 gtttccgccg ttgcctccat tgccgatcag ggtggcgttg ccgccggagc cgccgacacc
1488301 gccgtttgcc accacgcttg cgccgccggc gccgccgtcg ccgccgttgc cgaccatccc
1488361 ggccttgcca cccttgccgc cgttcccccc gtcgccggcg atgccgagtc cgccggcgcc
1488421 gccggcgccg ccatcgccgt tgagcaggcc ggcgttgccg ccggccccac cgtcgccggc
1488481 ggtctcgccg aacccgccgg ctccgccggc cccgcccgca cccgagagcc cggcggcgtt
1488541 gccgccggcc ccgccggccc ccccgaccga cccgaattcg atgccagtcc cgccggcgcc
1488601 accagcgccg ccgtcaccga tcaacccgcc ggtgccgccg gtgccgccgc taccggccgc
1488661 gccccggacg ctgtcgccgc cggtaccgcc ggcgccgccg tcgccgatca gcttggcggc
1488721 cccgccgctg ccaccggacc cgccgatgcc gccggccatt tggtccgcac tggaggcgcc
1488781 gaaccctccg gtgcccccgg cgccgccggg accgaacagt gcgccggcac cgccgatgcc
1488841 gccgacgcct cctttgccgc cggtgccgcc ggggtcgggc gcgccgagac cggttccgcc
1488901 ggtgccgcca atgccgccag cgccgaagag gatgccggcg ttgccgcccg ccccgccggc
1488961 cccgccctca ccgcccacga gttggttacc ggtgccagtt ccgccggtgc cgccggtccc
1489021 gccgttgccg gtgaagatgc cgccgtcgcc tccggtgccg ccgttccctc cggccgagcc
1489081 ggagactccg aacccgccgg cgccgccggc accgccattg gagaacagcc cgccgccccc
1489141 gccggtgccg ccggtgccac cggtgccccc gttgacgctc aacccgccgg tgccgccggc
1489201 accgccggcg gccaacacct cgaacagccc gctgcgaccg ccggccccgc cggcgccacc
1489261 gttgaagcct ggcccgccgg ccccgccgat gccaccggct ccgaacagcc cggccgcccc
1489321 gccgtcgccg ccgagcccgc ctgtgccggt gttcccgact ccgccgggcc caccggcgcc
1489381 gccggagccg aacagcagcc cgccggcccc gccggccccg ccagccgcgc cgttgcccgg
1489441 gccgtcaccc ccggccccac ccgccccgcc gttgccgaat agccccgcgg ctccacctgg
1489501 gccgccggcc tggccgggcg ccccggaccc gccggccccg ccgttgccgt acagcagccc
1489561 gccggccccg ccggcttgcc cggtccccgg tgcgccgttg gcgccgttgc cgatcagcgg
1489621 acgccccagc aacagctggg tgggcgtgtt cacaatgttg agcaggccct ccaacggcgc
1489681 cgcggcggcg gcctcagcgc tcgcgtacgc gccagcgccc gcagtaaagg tttgaacgaa
1489741 ctgggcatga aacgccgaca tctgagcgct caccgcctga taggcctggc catgcgcggc
1489801 gaacagcgac gcgatggccg ccgacacctc atcagcaccg gctgccagaa gttccgtcgt
1489861 cgggcccaat gccgcggcgt tggcggcccc cagcgtcgac ccgatgttcg ccaaatccga
1489921 agcggccctc accagcgtct cgggagcggc gattacaaac gacatgcttt cctccgatca
1489981 gctgtgcgtc gagtatccag ctcgagttag cacagggtag cgctatcgct tagcctttct
1490041 gatcaatctc ggagtgcagt gtgcagagtg catcgaatcg gctcatcagg catgtgcaat
1490101 ctgctcatgg caggcgctag gcgggcgtca gccacagcgc cgaagtgggc ggcagcacca
1490161 gcaccgcgga cgccgggcgg ccatgccagg ggtcgtcggt ggcgtccacg ccgccgaggt
1490221 tgccgatccc tgagccgtgg tagatcgtcg cgtcggtatt gagcacctcg cgccagcggc
1490281 ccgcgcgcgg cagcccgagt cgatagtcac ggtgttcggc acctgcgaaa ttgaacacgc
1490341 aggccagcac cgagccgtcg ctgccgtagc gcataaagct caacacattg ttggcggagt
1490401 cgttggcgtc gatccaagaa tagccttcgg gggtggtgtc taagctccac agcgccgggt
1490461 ggcatcggta gatgtcgttg atgtcgcgca ccagccgctg aatcccgttg gagaagccgt
1490521 tttcgtcgag ttggaaccag tccaggccgc gctgctcgga ccattcggcg cgttggccga
1490581 attcctgacc catgaacagc aattgcttgc cggggtgtgc ccattggtag gcaagcaggc
1490641 tacgcaggcc ggcggccttg acgtgattgt tgcccggcat ccgcccccac agcgtgcctt
1490701 tgccgtgcac cacctcgtca tgactgagcg gcaacacgta attttcgctg aacgcataca
1490761 gcatcgagaa cgtcatctcg tggtggtggt agctgcggta caccggatct cggctgacgt
1490821 agtcgagcgt gtcgtgcatc cagcccatgt tccacttcat cgaaaagccc aggccgccaa
1490881 tgttggtcgg gcgggtcacc ccagaccacg gcgtggactc ctcggcgatg gtgacgattc
1490941 ccggcgcgac cttgtgcgcc gtggcgttca tctcctgcag gaactgcact gcttccaggt
1491001 tctcccggcc gccgtggacg ttgggggtcc agccgccctc gggtcgcgag tagtctagat
1491061 agagcattga ggccaccgcg tccacccgca ggccgtcgat gtggaactcc tgtagccagt
1491121 acaacgcatt ggctaccaga aagttgcgca cttccgggcg gccgaagtcg aacacgtatg
1491181 tgccccaatc cagttgctcg ccgcgtttgg gatcggaatg ttcgtagagc ggagtgccgt
1491241 cgaaccgtcc cagggcccac gcgtccttcg ggaagtgcgc tgggacccaa tccacgatga
1491301 cgccgatgcc ggcctggtgc agggcgtcga ccagcgcccg gaagtcgtcg ggtgtgccga
1491361 atcgtgatgt cggcgcatag taggacgtga cctgataccc ccatgatccg gcgaatggat
1491421 gctcggcgac gggcaacagc tccacatggg taaacccttg atccacaatg taatccgtca
1491481 actcacgagc aagctggcgg tagctgagtc caggccgcca cgaaccgaga tggacttcgt
1491541 aggtgctcat cgcctcgttc accgggttgc gcagcgcacg cccagccatc cagtcgtcgt
1491601 caccccaggt gtagtcactc gacgtcaccc gcgatgcggt ctgcggcggc acctcggtgc
1491661 cgaacgcgaa cgggtcggcc cgatcggtaa ccacgccgtc ggcgccgtgc acgcggaact
1491721 tgtacagacc gtcgcaaggg aagtcgggcc agaacaattc ccatacccct gatgggccga
1491781 gcacccgcat gggggcttcg tggccattcc aaccgttgaa ctcgccgatc aagctgacgc
1491841 ccttggcgtt gggcgcccac acggcgaacg acacgccact caccacaccg tcggccgtgg
1491901 taaacgagcg ggggtgggca cccaggactt cccaaagccg ttcgtggcgg ccctcggcga
1491961 acaggtgcag gtcgacctcg cccagggtgg gcaggaatcg gtacgcatcg gccacggtgt
1492021 gtggctcgca accttcatag gtcacctgca ggcggtagtc gatgaggtcg acgaacggca
1492081 atgcgacggc aaacaggcca gaatcgaggt gctgcaacga gaaccggtcc ttaccaacga
1492141 gcgcgacgac ctcgacggca tgcggacgga acgctcggat gacggtatgg tcgtcgtatt
1492201 cgtgggcgcc caggatgccg tgcgggttgt gatgtgtacc cgccaccaag cgcgccattt
1492261 cggccggctc gggtgcaagg tgctccccgg tgagtttctc ggatcgactc atgagcccgt
1492321 cacctcctgc gcagcagcgt gtttcggctc tcgtagggca cggctggcat gttgatgatg
1492381 tgggcgactg cccgtgctgg gtcgatgcgg atgtaattgg cttgccccca ttggtattct
1492441 tcgccggtta tctcgtcgcg cacccaaaac cggtcgtagt cctccatgcc caacgccgcc
1492501 atgtccaacc acagcgtagc ttcttcagga ccaaatgcgt tgagtgtcac caccaccaac
1492561 acgcagtcgc cggtggccgg gtcgaacttg ctgtaggcca gcaacgcgtc gttgtcaacg
1492621 tggtgaaaat gaatggtacg caactgttga aacgccgggt gcagccggcg aattatattg
1492681 agccgtgtga tgaacggctg caaagatcta ccctggtcca gcgcgctggc aaagtcgcgg
1492741 ggacgcaatt cgtacttctc cgagtccagg tactcctcgc tgccctcgcg caccgcacgg
1492801 tgctcgaaaa gctcataacc gcagtacatc ccccaggctg ggctcatggt ggcggccagc
1492861 accgcgcgga tggcgaacat gcctggaccg ttgtgctgca gcaccgcgtg caggatgtcc
1492921 ggggtgttga cgaacaggtt gggccgacgg tagtcggcga gttcggctat ctggttgccg
1492981 aattcggtga gctcccactt ggtcgtgcgc caggtgaaat agctgtagga ctgcgtgaag
1493041 ccgagcttgg ccagcccgta ctggcgggcg ggcggggtga aagcctcgga caggaacagc
1493101 acgtcggggt cgacggtctt cacctgcgcg atcagccagg cccagaagtt gggtggtttg
1493161 gtgtggggat tgtcgacgcg aaagaacttg acgccgtggt taacccaatg ttgcaccacg
1493221 cgcagcactt cgtcgtacag gccctcggga tcgttgtcga agttgagcgg atagatgtcc
1493281 tggtacttct tcggtggatt ctccgcgtag gcgatggtgc cgtccggcag ctcggtgaac
1493341 cactgccggt gttcgcgggc ccacggatga tccggtgcgc attgcagcgc caggtccagc
1493401 gcgacctcca tgcccagatc gcgtgccgcg gagacgaagt cgtcgaagtc gtcgatggtg
1493461 cccaggctgg gatgaacggt atcgtgaccg ccctcatcgc taccgatcgc ccacggcgat
1493521 cccacgtctg tcggtgcggc ggtgggcgag ttgttgcgac ccttgcgatg caccttgcca
1493581 attggatgga tcggcggcag gtacaccacg tcgaacccca tgccggcgat gcgcggaagt
1493641 tctgccgcag cggtggcgaa ggtgccgtgt accgggttgc cgtcgtcgtc ccacccgccg
1493701 gttgagcgcg gaaacatctc ataccaagcg ccgaaccggg ccaacggccg atccacccag
1493761 acgccgaatt gctcgccccg ggtgaccagg tcccgcagcg gatagtcggc cagcagctct
1493821 tcgatttccg gtgtcagggc caacgcggtg cgggtcaccg ggtcaccggg ggtccgcagc
1493881 gctgccgcgg ccgccaggag gggatcgcgt aacccgcgcg gcacaccggt cgccgcgcgc
1493941 tccaacagca ccgcgcctac caacaggtcg ttggacagct cggtctctcc ctggccggca
1494001 tctagcttgg ctatcagccc atggcgccag gtgtggatcg ggtcacccca accatccacc
1494061 cggaaggtcc acaatccgac ccggtcgggg gtgaactggc cgtggaaaac gaagggctcc
1494121 tggccgctcg tcatcgggat cagcagcggc ttgacgcgtt gttggggctc gctcggcgtc
1494181 ggaagcaccc tggcccgggg tctgtcggtg aggtgtgggt aacgcactcc gaggtagcgc
1494241 acgaccagcg tcgctgcgac ggcctcgtgg ccttcacgcc agaccgccgc gctgaccggg
1494301 accacctcgc cgaccaccgc cttggcggga tatacgccgc acgaaacgac gggcgcgacg
1494361 tcatcgattt cgacacgacc gggcacccac cactccgttt ccgttccgat tgcccggcca
1494421 ctcaccggga catcttgtat gtgtcgttcc ttgtgtgtcc ttcttgcgcc cgatacccac
1494481 cctagtatcc gatcacaccc gcgaaggcac agcggtcggc gggcgcactg cacgcggtgg
1494541 catcctcagt aaggtaagga cgcgtgaaag cccttcgccg gtttaccgtc cgagcccacc
1494601 tacccgaacg tcttgccgcc ctggaccagc tgtctaccaa tctgcggtgg tcctgggaca
1494661 aaccgacaca ggatctgttc gcggcgatcg accctgcact gtgggagcaa tgcggtcatg
1494721 atccggtggc gctgctgggc gcggtgaacc cagcgcgtct cgacgaactt gcgctggacg
1494781 cagaattttt gggcgccctc gatgagctgg cggccgactt gaacgactac ctgagccgtc
1494841 cgctgtggta tcaggagcag caggacgccg gggtagccgc acaagccctg ccgaccggga
1494901 tcgcgtactt ctcgctggag ttcggggtag ccgaggtgtt gcctaattac tcgggcggtc
1494961 ttgggattct cgccggcgac catctgaaat ccgcgtccga tctgggcgtg ccgctgatcg
1495021 cggtggggtt gtactaccgc tccggctact tccggcaatc gcttaccgcg gacggctggc
1495081 agcacgagac ctacccatcg ctggacccgc aagggctgcc gttgcgtctg ctcaccgacg
1495141 ccaacgggga tccagtgctg gtcgaggtcg ccctgggaga caacgccgtg ttgcgcgccc
1495201 ggatctgggt agcgcaggtg ggtagggttc cgttgctctt gttggattct gatatcccgg
1495261 agaacgagca cgacctgcgc aacgtcaccg accgcctcta cggtggcgac caggaacatc
1495321 gcatcaaaca agagatcctg gccggcatcg gcggggtgcg ggcgattcgt gcgtacaccg
1495381 ccgtcgaaaa gctcaccccg cctgaggtct tccacatgaa cgagggccac gccggattcc
1495441 tcggcatcga acgcatccgt gaactggtca ccgatgcggg tttggatttc gacaccgcat
1495501 tgactgtggt gcggtccagc acggtgttca ccactcatac tcccgtcccc gccgggatcg
1495561 accggttccc gctcgagatg gtgcagcgct acgtcaatga ccagcgcggc gatggccggt
1495621 ctcggctgtt gcctgggttg ccggccgacc gcatcgtcgc gttgggcgcc gaggacgatc
1495681 cggccaaatt caacatggca cacatgggcc tgcggctggc gcagcgggcc aacggcgtct
1495741 cgttgctgca tggccgggtc agtcgtgcca tgttcaacga gctgtgggcg ggattcgacc
1495801 ccgatgaggt gccgatcggc tccgtcacca acggtgtgca cgcgcccacc tgggcggcgc
1495861 cgcagtggtt gcagctgggc cgcgagctgg ccgggtcgga ctctttgcgc gagcccgtcg
1495921 tttggcagcg actgcatcag gtcgatcctg ctcatctgtg gtggatccgc tcacaactgc
1495981 ggtcgatgct ggtggaggac gtccgggcgc ggttgcggca atcatggctg gaacgtggtg
1496041 caacggatgc cgaactgggt tggatcgcga cggcattcga tccgaatgtg ctcaccgtcg
1496101 gcttcgcccg gcgggtcccg acctacaagc ggctgacgtt gatgttgcgc gatcccgatc
1496161 ggctcgagca actgctgctc gacgaacagc ggccgatcca gctgatagtg gctgggaagt
1496221 cgcacccggc cgacgacggg ggcaaagcgc tgatccagca ggtggtgcgg ttcgccgacc
1496281 ggccgcaggt ccgccaccgc atcgccttcc tgccgaacta cgacatgtcg atggcccggc
1496341 tgttgtactg gggctgcgac gtctggttga acaacccgct gcggccgcta gaggcgtgtg
1496401 gtacctcggg catgaaaagc gcgcttaacg gcgggctgaa tttgtcgatc cgtgacggct
1496461 ggtgggacga gtggtacgac ggcgaaaacg gttgggagat accgtctgcc gacggtgtgg
1496521 cggacgagaa ccgtcgcgac gacctggagg ccggcgcgct ctacgacctg ctggcacaag
1496581 ccgtggcacc gaagttctac gagcgcgatg aacgcggggt gccgcagcgg tgggtagaga
1496641 tggtccggca taccctacaa acgctcgggc ccaaggtgct ggcttctcga atggtgcgcg
1496701 actacgtcga gcattactac gcgccggcgg cgcagtcttt tcgccggacc gcgggcgccc
1496761 agttcgacgc ggcccgcgag ctggccgact accgccggcg cgcggaagaa gcgtggccca
1496821 agatcgagat tgccgacgtc gacagcaccg gtctgccgga tactccactg ctcgggtccc
1496881 agctgaccct gacggcaacc gtgcggctgg ccgggctgag gccaaacgac gtgacggtgc
1496941 agggggtgct gggcagggtc gacgccggcg atgtgctaat ggatccggtc accgtcgaga
1497001 tggcgcatac cggcaccggc gacggcggct acgagatctt ctcgacgacg acgccgctgc
1497061 cgctggcggg gccagtcgga tacaccgtgc gggtgctgcc tcgccacccg atgctggccg
1497121 ccagcaacga gctcggcctg gtcaccctgg cctgacccgc cgagaagacg caaaagctcc
1497181 taaatctggc cgatttagtg ggcttttgcg tctgctcgcg caaggcgccg cagggccgcg
1497241 cgcacttgcg tggcgttggt ggtctgccaa aagggcggca gcgaggctcg caggaattcg
1497301 ccatagcggg cggtagccat ccgtgaatcg agcaccgcaa ccacgccccg atcggtgacg
1497361 cgccgtaaca gccggccgga tccctgtgcc agcagcagcg ccgcgtggct ggcggcgacc
1497421 gtcatgaagc cgttgccgcc acgggcggcc accgcacgct ggcgggcact cagcagggga
1497481 tcgtccggcc gggggaacgg gatgcggtcg atcaacacca acgacagcga cggtcccggc
1497541 acgtcgaccc cctgccacag cgacagcgtg ccgaacaggg aggtcgccgc atcggcggtg
1497601 aacttctcca ccagcgtgga cgtactgtcg tcgccctgac acaacaccgg cgtggacagc
1497661 cgttcgcgca tggcctcggt ggctgcccgg gcggcccgca tggacgagaa cagccccagg
1497721 gtgcgcccac ctgcagcggt gatgagttcg gcgatctcgg tcagttgttc ggccgagccg
1497781 ctgccgtctc ggcccggcgg cgggagatgg gcggccacgt agaggattcc cgactttgcg
1497841 tgctggaaag gcgagcccac gtccaggcca cgccagggcg tgtctgcagt caggccccat
1497901 gccgtggcca tcgcgtcaaa cgacccgccg attgtcagcg ttgccgaggt caatacggtc
1497961 gttgcacggg cgaacacctg ggtggccaac agctcggcca ccgatagcgg agccacccgc
1498021 agcaccgcgc gagccgattc gtggttgtcc tcgtgctcca gccaaaccac gtcgctgcgg
1498081 tcagggatag cgggggcgaa cgacgccagg attcgtgacg cggtatcgga tatttcggtc
1498141 agtaccgcgc ccgcttcggc gcgcacggac gccgtcgtgg tgtcgctgcc ggtatcgatc
1498201 gctgagcgcg ccgcactggc cgcatcgcgc agcgcgctca gataggtcgc catctcgtca
1498261 tcgaggcaat caatgcggcc cggtctggcg tcgtgaatcg ccgaactgaa ggtagccgaa
1498321 gccgcctgaa gccgctgggt cactttcggg tcgaccagcc gggtgatccg tcgtgcggcc
1498381 ataccgagcg tggcagacgt cagctcagcg gcggctaccg aggtcacccg gtcggccaat
1498441 tcgtgagcct cgtcgacaac cagcagccga tgttctggca gtaccgccga ttcggcgacg
1498501 gcatcgatgg ccagcagcgc gtggttggtg acgacgacat cggccaggcc ggccgctcca
1498561 cgagcccgtt cggagaagca ctccgagcca aacgggcagc gggccacgcc gaggcattcc
1498621 cgcgccgaaa cgctgacctg cgaccaggat cggtctccca caccgggctt aaggtcgtcg
1498681 cgatcaccag acacggtcgt cgaagcccag gcggttagcc gttgcacatc gcgtcccagc
1498741 gcggtgaccg ccaccgggtc gaagagctcc tcctgcggcc gctcgtcgtc atggtcactg
1498801 gctgtgactg agttgtggat cttgttcagg cacaggtagt tccgtcgacc tttgagcagg
1498861 gcgaacttcg gtcggcgggg gagcgcattg gtgagcgaat ctaccagctg gggcaggtca
1498921 cgatcgacga gttgacgttg caaagcgatc gtcgccgtcg acaccacgac cggcgcgtcg
1498981 tcgcaaagag cgcggatgat cgcgggaacc agatacgcca gcgacttgcc ggttccggtg
1499041 ccggcctgga ccaccaagtg ctcaccggtt tcaaacgcat gcgctaccgc ggcggccatc
1499101 tcttgctggc cgcgacgccg ggtgccgcca agtgccgcca cggcgatggc aagcagctca
1499161 ggcacagaca tggataccga ctcggacacg ggacgtggtc acatccttgc gctcaggccg
1499221 ggatcgtgcg tgtcggaatc gccggctcgc cgggtgccaa tttcagcccg tcgcctggca
1499281 ggctgcgcaa cccggatgcc accagctgcc gtgccgcggc caggctggta tcggctaccg
1499341 gttgcccggc gcggaccagt ggcagcgtca aaacccggtg cggctcgaca atgaccggcg
1499401 gacggcccgc cggatgcacg agctcctcgg tgatggtgcc cgtcgcacgg gagcgccgca
1499461 gtgcctcttt gcggccgccg ggggattctt tgtagctgct gcgcttttgc accggtacac
1499521 cgtctacctc gaccagtttg tagaccatgt tggcggtcgg cgcgcccgac ccggtgacca
1499581 gcgacgtgcc cacgccgtag ctgtcgacgg gttcaccgcg caacgcggcg atgctgaact
1499641 cgtcaaggtc gccggacacc acgatgcgcg tccgggtggc tcctagccgg tcgagctgct
1499701 cccgcgcttg gcgggccagt accccaagct caccggaatc gatgcggatc gcgccgagct
1499761 cagcgccggc ggcggcaacg gcattggcca caccggtcgt gacgtcatag gtatccacca
1499821 gcagcgtggt accgggtccc agcgcttcga cctgggcgcg gaatgcggct cgctcggcta
1499881 gttcggtggg gccgccatgc tgggcgtgca acatggtgaa tgcgtgtgcc gcggtgccgt
1499941 gcgcgggcac tccgtagcgt cgctgcgccg ccaagttgga tgacgcggcg aaaccggcga
1500001 tatacgccgc ccgggccgct gccaccgcgg cgcgttcgtg ggtgcgccgc gagcccatct
1500061 cgatcagtgg gcgccccccg gcggcgctga ccatgcgcgc cgctgccgag gcgatcgctg
1500121 tgtcgtggtt gaagattgac agcaccagcg tttcgagcag gacgcattcg gcgaagctgc
1500181 cgcgtaccga gagcaccggt gacccgggaa aatacagctc cccctcggca tagccgtcga
1500241 tatcgccgcg gaaccggaat tcgcgaagat accgcaccgt ggccgggtcg aggaattggg
1500301 ccagcaactc gcacgcgtca gcgtcgaacc tgaactgcgg caacgcttcc agcaaccggc
1500361 cggttccggc gacaactccg tagcgacggc cggtggggag tcggcgagcg aacacctcga
1500421 atgtggtggg gcgattggcg ctgccgtcgc gcagggcagc cgccagcatg gtcaactcgt
1500481 acttgtcggt caacagcccg gctgggtctt gattgtcggg ctctccctct cgccgcctgg
1500541 cggctggggg tggccccaca gcggtccgac gcggtccgca gcgtcgcccg gttgggaccc
1500601 agtcgttcac accgccacgg tatcggctcg cggccacggt gcgctgggta tcctggggcc
1500661 atggctgttg tgtcagcgcc cgccaagcca ggtaccacct ggcagcgcga gtctgctccg
1500721 gtcgacgtga cggacagggc atgggtcacc atcgtgtggg acgacccggt caacttgatg
1500781 agctacgtga cttacgtgtt tcagaagttg ttcggctaca gcgagccgca tgccaccaag
1500841 ctgatgttgc aggtgcacaa cgaaggtaag gcggtggtgt ccgcgggcag ccgagagtcc
1500901 atggaagtcg acgtgtccaa gctgcatgcc gccggtttgt gggcgacgat gcagcaggac
1500961 cggtgagatt cgaggatatt cgggatccat cgtgcgcagg tggaagcgcg tcgagacccg
1501021 cgatggtccc cgctttcgat cgtcgttggc tccgcatgag gccgccctgc tcaagaacct
1501081 ggcaggcgcg atgatcgggc tgctcgacga tcgcgactct tcttcgccgt cagacgaact
1501141 cgaggagatc accggcatca agaccgggca tgcgcagcgt ccgggtgacc cgaccttgcg
1501201 tcggctgttg ccggatttct accgtcccga tgacctggat gacgatgatc cgacggccgt
1501261 cgacggctcc gagagcttca acgctgccct gcgcagcctg cacgaacctg agattatcga
1501321 cgccaaacgt gttgccgcgc agcagttatt agacacggtt ccggacaatg gcggccggtt
1501381 ggagctgacg gaatccgacg ccaatgcttg gatcgccgcc gtcaacgacc ttcggctggc
1501441 gctcggagtg atgcttgaga tcggcccgcg tgggccggag cgcctgccgg ggaaccaccc
1501501 gttggccgcg cacttcaatg tctaccagtg gctgacagtc ctgcaggaat acctcgtgct
1501561 ggtgctgatg gggtctcgat gatctgcgcg gcggcccgat gaactccatc accgacgtcg
1501621 ggggcatccg ggttggccac taccagagac tggaccccga cgcgtccctc ggcgccgggt
1501681 gggcttgtgg cgtcacggtg gtgttgccgc cgcccgggac ggtcggtgcg gtcgattgcc
1501741 gcggcggcgc ccctggaacc cgcgagactg atctgctgga cccggccaac agcgtgcgct
1501801 tcgtcgacgc cctgttgctc gccggcggca gcgcctacgg tctggccgcc gccgatggcg
1501861 tcatgcgctg gctagaggaa caccggcgcg gcgtcgcgat ggacagcggc gtggtgccca
1501921 tcgtgccggg cgcggtgatt ttcgaccttc cggtcggcgg ctggaattgt cggccgacgg
1501981 ccgatttcgg ctattcggcc tgtgcggcag ccggagtcga cgtcgcggtc gggacggtgg
1502041 gcgtgggggt tggggcgcgc gccggagcgc tcaagggcgg tgtcgggact gcatcggcta
1502101 ccctgcagtc cggtgtgacc gtcggtgtcc ttgctgtggt aaatgccgct ggcaacgtcg
1502161 tcgatccagc caccggcttg ccgtggatgg ccgacctagt cggcgagttc gcgttgaggg
1502221 ccccgccggc cgagcagatt gctgcgctgg cgcagttatc gtccccgctg ggagccttca
1502281 acaccccgtt caatacgacg atcggtgtga ttgcgtgtga cgccgcgctg agccctgcgg
1502341 cttgccggcg catcgcgatt gccgcccacg acgggttggc ccgcaccatc cggccggcac
1502401 acaccccctt ggatggcgac acggttttcg cgctggccac cggcgcggta gcggtgccgc
1502461 cggaggccgg cgtgccggcc gcattgtctc cggagactca gctggtcacc gcggtcggtg
1502521 cggcggcggc tgattgcctg gctcgtgcgg tgctggccgg cgtgctcaat gctcagccgg
1502581 tagccggaat accgacctac cgtgacatgt ttcccggagc attcgggtcc tgaaacttcg
1502641 gtgttgctta ggaaaggaac cgtctacgtg ctggtgattc gcgcagacct ggtgaatgcg
1502701 atggtggccc atgcgcgtcg cgaccacccc gacgaagcct gcggagtgct ggccggaccc
1502761 gagggctctg accgtcccga gcggcatatc ccgatgacca atgccgagcg ctcgccgacc
1502821 ttctaccggt tggattccgg tgagcaactg aaggtgtggc gggctatgga agatgccgac
1502881 gaggtcccgg tcgtcatcta tcactcgcac actgcgaccg aagcgtaccc gagccgtacg
1502941 gacgtgaagc ttgccaccga acccgacgcg cactacgtgc tggtgtccac ccgcgacccg
1503001 caccggcacg agctacgcag ctaccgcatc gtcgatggcg ctgtcaccga ggaacctgtc
1503061 aatgtcgtcg agcagtactg aaccgttccg agaaaggcca gcatgaacgt caccgtatcc
1503121 attccgacca tcctgcggcc ccacaccggc ggccagaaga gtgtctcggc cagcggcgat
1503181 accttgggtg ccgtcatcag cgacctggag gccaactatt cgggcatttc cgagcgcctg
1503241 atggacccgt cttccccagg taagttgcac cgcttcgtga acatctacgt caacgacgag
1503301 gacgtgcggt tctccggcgg cttggccacc gcgatcgctg acggtgactc ggtcaccatc
1503361 ctccccgccg tggccggtgg gtgagcggag cacatgacac gatacgactc gctgttgcag
1503421 gccttgggca acacgccgct ggttggcctg cagcgattgt cgccacgctg ggatgacggg
1503481 cgagacggac cgcacgtgcg gctgtgggcc aagctcgagg accgcaatcc gaccgggtcg
1503541 atcaaggacc gcccggctgt gcggatgatc gagcaggccg aggccgacgg gttgttgcgg
1503601 ccgggcgcca ccatcctgga gcccaccagc ggaaacaccg gcatttcgct ggcgatggcg
1503661 gcccggttga aggggtaccg attgatctgc gtgatgccgg agaacacatc ggttgaacgg
1503721 cggcagctgc tcgagctcta cggcgcgcag attatcttct cggcggccga aggcgggtcc
1503781 aacactgcgg tggccaccgc caaagagctg gccgcgacca acccgtcatg ggtgatgctg
1503841 taccagtacg gcaatcccgc caacaccgac tcgcactact gcggcaccgg ccccgagctg
1503901 ctggccgacc tgcccgaaat cacgcacttc gtcgccggcc taggcaccac gggcacgctg
1503961 atgggcactg gccgtttcct gcgcgagcac gttgccaacg tcaagatcgt ggcggccgaa
1504021 ccccgctacg gtgagggggt atacgccctg cgcaacatgg acgaaggctt tgtgcccgag
1504081 ctgtatgacc cggaaatact gaccgcgcga tattctgtcg gcgcggtgga cgcagtgcgc
1504141 cgcacccgcg agttggtgca caccgaaggc atctttgcgg gcatctcaac cggcgcggtg
1504201 ctacacgccg cactcggagt cggggccggc gccctggcgg ccggcgagcg ggccgacatt
1504261 gcgttggtgg tcgccgacgc cgggtggaag tatctgtcca ccggcgccta cgccggtagc
1504321 ctggatgacg ccgagaccgc tctggaaggg caactatggg catgaccccg cgccggaagc
1504381 gacggggagg agcggtgcag ataacacggc ccacaggccg tccgcgaaca ccgacaacgc
1504441 agacgacgaa gcgcccgcgc tgggtggtcg gcgggacgac gatcctcacc ttcgtcgcgc
1504501 tgctctatct cgtcgaactg atcgaccagc tgtccgggag tcggctggac gtcaacggca
1504561 tcaggccgct gaaaacagac ggcctgtggg gcgtcatctt tgcgccactt ttgcacgcga
1504621 actggcacca cctaatggcc aataccatcc cgctgctggt gctggggttt cttatgacgc
1504681 tggccgggct gtcccggttt gtctgggcca ccgcgatcat ttggattctg ggcggcttgg
1504741 gcacttggct gatcggcaat gtgggcagca gctgtggccc gaccgaccat atcggcgcct
1504801 ctggcctgat ctttggctgg ctggccttcc tattggtgtt cgggcttttt gtgcgcaagg
1504861 gatgggatat cgtcattggg ctggtggtct tgtttgtcta tggcggcatc ctgctcggcg
1504921 cgatgccggt gctgggccag tgtggtggcg tgtcatggca gggtcattta agtggtgcgg
1504981 ttgctggcgt cgtggcggcg tatctgttgt ccgctccgga gcgtaaggcc cgtgcactga
1505041 aaagggccgg cgcgcgttcc gggcatccga agttatgaat tcgccgttgg cgcccgtcgg
1505101 agtctttgat tccggcgtcg ggggactgac ggtcgcgcgg gccatcatcg accaactgcc
1505161 cgacgaggac atcgtctacg tcggcgacac cggtaacggc ccgtacggtc cgctgaccat
1505221 cccggagatc cgggcgcacg cgctggccat cggcgacgat ctggtcggcc gaggcgtcaa
1505281 ggcgttggtg atcgcctgca actcggcgtc gtcggcgtgc ctgcgggatg ctcgcgagcg
1505341 ctaccaggtg cccgtcgtcg aagtgatact gccggcggtg cggcgtgcgg tggccgccac
1505401 ccgcaacggc cgcatcgggg taatcggcac gcgggcgacc atcacttcac acgcctatca
1505461 ggacgcgttc gctgcggccc gcgacaccga aatcaccgcg gtggcttgcc ctcgcttcgt
1505521 ggacttcgtc gagcgcggcg tcaccagcgg tcgtcaggtg ctcggtctgg cgcagggcta
1505581 cctggaaccg ctgcagcgcg ccgaggtcga cacgctagtg ctgggctgta cgcactatcc
1505641 actgctgtcc ggactgattc aactggcgat gggcgagaac gtcacgctgg tctccagcgc
1505701 cgaggagacc gctaaggaag tggtccgggt gctcaccgag atcgacttat tgcgtccgca
1505761 tgacgcgccg ccggcaactc ggatatttga agctacgggc gaccccgaag cgtttaccaa
1505821 attggccgca cgattcctgg gtccggtgct cggtggtgtg caacccgttc acccatcgcg
1505881 cattcattag gccatggaag agattctcgt caccgaatgc gtcgatgtat tccgcatcgt
1505941 tgtatcgggc atggcacagt agtgtccgtg cggataaccg tgctcggatg ctccggtagc
1506001 gtcgtggggc cggattcgcc tgcgtcgggg tatttgctcc gagcgccgca cacaccgccg
1506061 ttggttatcg acttcggcgg gggtgtgctc ggcgcgctgc aacggcacgc ggatcccgcg
1506121 tcggtgcatg tgctgctgtc gcatctgcat gcggaccatt gtctggactt gccgggactt
1506181 tttgtgtggc ggcgttacca cccgtcgcgt ccctctggca aggcattgtt gtacggcccc
1506241 agcgacacct ggtcgcgatt gggggcggcg tcgtccccgt acggtgggga gattgacgac
1506301 tgttcggata tcttcgatgt tcaccactgg gccgacagtg agccagtgac gttgggcgcc
1506361 cttacgatag tgccgcggct ggttgcccac ccgactgagt cgtttggcct gcggatcacc
1506421 gatccgagcg gtgcgtcact ggcttatagc ggcgacaccg gcatttgtga ccagctcgtc
1506481 gagctggctc gcggcgtcga cgttttcctc tgcgaggcct cctggacaca ctcgcccaaa
1506541 catccacccg atctacacct gtcgggcacc gaagccggta tggttgccgc gcaagccggc
1506601 gttcgtgagc tgctgctgac gcatatcccg ccgtggactt cgcgtgagga cgtcatcagc
1506661 gaggccaagg ccgagttcga cggcccggtg cacgcggtgg tatgcgacga gacgttcgaa
1506721 gtccggcgag ccggctaggt ctagggttgg cgtcgtgtcc aagcgagaag acggccggct
1506781 cgaccacgag cttcgcccgg tgatcatcac ccgcggtttc accgaaaacc cggcgggatc
1506841 ggtgctcatc gaattcggtc acaccaaggt cctgtgcacc gccagcgtca ccgaaggggt
1506901 gccccggtgg cgtaaagcaa ccggtctggg gtggctcacc gcggagtacg ccatgctgcc
1506961 gtcggccacc cacagccgct ctgatcgcga gtcggtgaga ggcaggctta gcgggcgtac
1507021 tcaggaaatc agtcggctca tcggccggtc gctgcgcgca tgcatcgacc tggcggcgct
1507081 gggggagaac acgatcgcta tcgattgtga tgtgttgcag gccgatggtg gcactcgaac
1507141 cgcggccatc accggcgcct acgtggcatt ggccgacgca gtgacctact tgtcggcggc
1507201 gggtaagttg tccgacccca ggccattgtc gtgtgccatc gccgcggtca gcgtcggtgt
1507261 tgtcgacggc aggatccggg tggatctgcc ctacgaggaa gattcgcgcg ccgaggtcga
1507321 catgaacgtc gtcgctaccg acaccggaac cctggtagag attcagggca ccggcgaagg
1507381 cgcgacgttc gcacgttcga cactggataa gctgctggac atggcactgg gcgcctgcga
1507441 cacgttgttt gccgcacaac gcgacgcgtt ggcgctgccg tatccgggtg tgctgccgca
1507501 gggaccgcca ccgccgaagg cgtttggcac ctgaccgcgc cgcgacgatg cagagcggag
1507561 cgatgaggag gagtggcgct tgtgaccaag cttctggtcg ccagccgcaa ccgcaaaaag
1507621 ctggccgaac tgcgccgggt gttggacggc gccggactat cgggtttgac gctgttgtcg
1507681 ctgggcgatg tgtcgccgct gcctgaaaca ccagaaaccg gtgtgacatt cgaggacaac
1507741 gcgctggcca aggcgcgcga cgcgttctcc gcgaccggac ttgccagcgt tgccgacgac
1507801 tccggtttgg aggtggccgc actgggcggc atgcctggcg tgctgtcggc ccggtggtcc
1507861 ggcaggtatg gcgacgatgc cgcgaacacc gcgctgttgc tggcgcagtt gtgcgatgtg
1507921 cccgatgagc ggcgcggagc agcgttcgtg tcggcctgcg cgttggtctc ggggtccggc
1507981 gaagttgtcg tgcgcggtga atggcccggc acgatcgccc gtgagccgcg cggtgacggc
1508041 gggttcggct acgacccggt cttcgtcccg tacggtgacg accgcacagc ggcccagctg
1508101 agcccggcgg aaaaggacgc ggtatcccat cgcggtcgcg cgttggctct gctgctgccg
1508161 gcgctgcgct ccctggcgac aggctaaagc ccgaagcggg ccttgatctc tttggtctgg
1508221 aagtgctcga cgacgatgcc gagcagcgga attgtgccgg cgagcagaac accggctgtt
1508281 ttgccgagcg gccagcggac cttgaccgcc aggttcaacg tcagaagcag atacgtgaag
1508341 tacacccagc cgtgcaccac accgatccac gtcggcggat tgtcaacctt gacgacgtag
1508401 cggaccacga tctcgtagca cagtgcgatg agccagaggc ccgtcgtcca cgccatgatc
1508461 cggtagccga gcaaagcggt gcgaatcctc tcgacggcga tggcaggctc ggcgtgctgc
1508521 gccgcgggcg tttcgggtgc ggtcatgcgg tggtcctgtt ctgcttcctg gcatcgtcct
1508581 tggctagctc ggctaggtag gcgttgtatt cccgtagtac gggatcgtcg ggtggctgct
1508641 gcgccggctt cggccgctcg ggcagcaatc cggcaggtat ctcggcggcg gcgccgccgg
1508701 tgggcggttg cgggggcgtc tcttcatacc gaacgaagtt gcggtacgcg tagacgcaga
1508761 accaagcaaa caatggccac tgcaacgcgt aacccagatt ttgaaaggtg cccgaggtcg
1508821 attgaaacct ggtccactgc caccaaccca gggccaggca accacaggtc gcgatgatca
1508881 ccaacgcgat cagcgcgggt ctgcgacggc gggtagtgga caccccacga cgttaccgcg
1508941 cactgctcta ttgggcgccc gggcgcgatg tggcgatatc cactaagtac aaggctagcc
1509001 ttgcctaata ccccaggtgt agcctccttc gccatgacct catcgccgtc caccgtcagc
1509061 actacgctgc tgagcatcct gcgcgacgac ctcaacattg acctgactcg agtcacgcct
1509121 gatgccaggt tggtcgacga tgtgggactg gattcggtgg ccttcgcggt cggtatggtg
1509181 gccatcgagg agcggctcgg agtcgcactg tccgaagagg agctcttgac gtgcgacacg
1509241 gtcggagaac tggaggcagc gatcgcggcc aaataccgcg atgagtgagc tcgcggccgt
1509301 gctcacgcgg tccatgcagg cctctgccgg cgacttgatg gtcctcgacc gcgagacctc
1509361 gctgtggtgt cggcacccgt ggcccgaggt acacgggctg gccgagagcg tagcggcctg
1509421 gctgctagac catgaccgac ccgccgcggt gggtctggtc ggcgaaccga cggtcgagtt
1509481 ggtcgccgcg atccagggtg cctggcttgc cggcgctgcc gtgtcgatcc tgcccgggcc
1509541 ggtacgtggc gccaatgacc agcgatgggc ggacgcgacg ttgacccgtt tcctcgggat
1509601 tggggtgcgc accgtattga gccagggttc ctaccttgcc cgcctgcgat cggtcgatac
1509661 ggccggcgta acgatcggag atctcagcac ggcggcgcac accaatcgtt cggccacacc
1509721 ggtggcgagt gaagggcccg cggtccttca aggtaccgcg ggatcgacgg gcgcgccccg
1509781 taccgccatc ctttcgccgg gcgcggtgct cagcaacttg cgtgggctca atcagcgcgt
1509841 gggcaccgat gctgcgaccg acgtcggttg ctcatggtta ccgctgtacc acgacatggg
1509901 gctcgctttc gtgctctctg ctgcgctggc cggtgcgccg ctctggttgg ccccgacgac
1509961 ggcgttcacg gcgtcgccgt tccgttggtt gagttggctc tcggacagtg gtgccaccat
1510021 gaccgcggca ccgaacttcg cctacaacct catcggcaaa tacgccaggc gggtatccga
1510081 ggtcgacctg ggtgccctgc gagtgacgct caacggtgga gagccggttg actgcgatgg
1510141 gctgacgcgg ttcgcggagg cgatggcacc gttcggattc gatgccggcg ccgtgttgcc
1510201 ctcctacggg ctcgccgagt cgacgtgcgc ggtgaccgtg ccggtccccg gaattgggtt
1510261 gcttgccgac cgtgtcatcg acggcagcgg tgcgcataag cacgcggtcc tgggtaaccc
1510321 catccccggt atggaggtac ggatctcgtg cggtgatcag gcggcaggca atgcgagccg
1510381 tgaaattggc gaaatcgaga ttcgcggtgc gtcgatgatg gcgggttacc tgggtcagca
1510441 gccgatcgac cctgacgatt ggtttgccac cggcgacctc ggctatcttg gcgctggcgg
1510501 cctggtggtg tgtggtcgcg cgaaggaagt catctccatc gcgggacgca acatctttcc
1510561 gacggaggtc gagctggtgg cagcgcaagt tcgcggagtg cgcgaaggcg ccgtggtcgc
1510621 cttgggcacc ggtgatcgct cgacccgccc cggtctggtg gtcgcggccg agttccgcgg
1510681 cccagacgag gcgaacgccc gcgccgaact gatccaacgc gttgcgtccg agtgcggtat
1510741 cgtcccgtcc gacgtcgtct tcgtgtcgcc tggatcactg ccccggacgt cgtctggaaa
1510801 actgcgccgc ttggcagtcc ggcgctccct ggagatggcg gactgatgac ggccggctcc
1510861 gacctcgacg acttccgcgg tttgctcgcc aaagcgttcg acgagcgggt ggtggcatgg
1510921 accgcagaag cggaagcgca ggaacgtttt ccgcgccagt tgatcgaaca cctgggtgtc
1510981 tgcggcgtat tcgatgcgaa gtgggcgacc gacgcccgtc ccgacgtcgg taaactcgtc
1511041 gaactcgctt tcgcgttggg ccagctggcc tctgccggca tcggtgtggg tgtcagcttg
1511101 catgactcgg cgatcgcgat tttgcgccgg tttggtaagt cggactactt gcgggatatc
1511161 tgcgatcagg cgatccgtgg cgccgcggtg ctgtgcatcg gagcctcgga ggagtccggc
1511221 ggatccgacc tgcagatcgt cgaaaccgag atacggtccc gtgacggtgg tttcgaggtc
1511281 cgcggcgtca agaaattcgt gtcgctgtct ccgatcgccg accacatcat ggtggtggcc
1511341 cgcagcgtcg accacgatcc gaccagtagg cacggcaatg tcgcggtcgt ggccgtgccg
1511401 gccgcacaag tcagcgtgca gaccccctac cgcaaggtcg gtgcgggacc gctggatacc
1511461 gccgcggtct gcatcgacac ctgggtaccg gccgatgcac tggttgcgcg ggccggcacg
1511521 gggctggcag ccatcagttg gggactggct catgagcgga tgtcgatcgc cgggcagatc
1511581 gcagcgtcgt gtcaacgggc gatcggaatc accctggccc gcatgatgag tcgacgtcag
1511641 ttcggtcaga cgctgttcga acaccaggcg ctgcggctgc gtatggcgga cctgcaggcg
1511701 cgtgtcgatc tgctgcggta cgcgctgcac ggcatcgctg aacaggggag actggaactg
1511761 cgcacggcgg cagcggtcaa agtcaccgcc gcccggctcg gtgaggaagt catctccgaa
1511821 tgcatgcaca tcttcggtgg ggcgggttat cttgtcgacg aaacgacgct tggcaaatgg
1511881 tggcgggaca tgaagctcgc ccgggtcggc ggcggcaccg acgaggtgct gtgggaattg
1511941 gtggctgccg gcatgacgcc cgatcacgac ggttacgcag ccgtggtcgg agcttccaaa
1512001 gcgtagagcg ccatgcgccg gtttgtcgtg tcatgctcac cgaggaactt gcatccggcc
1512061 cactcacaca accgacgggt cgcggtgttg cggtgatcgg ggtcgaacat gatccgccgg
1512121 caacgcggct cgttggcaaa gacgctggcc acgatccgcg gtagcagcag cgggccgaag
1512181 ccccgattga ccttcgacaa gtccgcgatg gccgcgtgca gccccaaatc gtaggggtct
1512241 gcgtcgtagt agtgagaaat caaatccttt gctgcccagt ataattcgag ataaccacca
1512301 tctgttccgt gccagctgcc gatcaatggc aacgaatagg ttccctcaag ttgggcgttc
1512361 aggtgttgac gccaacgtga cgccggccag tcgtactccc aggccgccgc cagatgagga
1512421 cggttcatcc actccgccaa catctccgcg tcggtcagct gtgcgacccg caacccgtat
1512481 ggcggctcca acgatggaac gggcgggcgg gcgaggcgtc gtacctggtc aggtaggtcg
1512541 aatcgctcgc gggctagccg aaccagcgcg tcgtcggcct ggccagcgga tgtgggtttg
1512601 gtcattgcgg gccgagctta ccggagggct cgctgcttag gttaggcatg ccatacatgc
1512661 gtgagccggg atcacgtcgc ccgctgcccg gctgtccggg ggtcgaggcg gtacgatcgc
1512721 tacgcccgcg ggcgtgatga aattggcaaa catgccggtt ttaggtgccg gtgctcgaaa
1512781 gagtttgagg gttcgagtcc ctccgcccgc actccatggt ccccgagttt gaccttcggt
1512841 aaggcaaccc ttagtttgga cgagatcgtc cgactggggc cgactgggtt gtatgcgcgg
1512901 gctgagtatc agcgcggtcg cggcgcagct cggggtatcg gcggagcgcg acgccgttgc
1512961 acgccggttg gccggtaacc cagcgttcgt ggtcgcccga tctgagaagt cgtggcggat
1513021 taggccgccg cgagagagga ccgctgatgg cacgcgggtt gcagggtgtg atgttgcgca
1513081 gtttcggcgc gcgcgaccac accgcaacgg tgatcgaaac catttcgatt gcaccgcatt
1513141 tcgtgcgggt ccggatggtt tcgccgacgc tcttccagga tgcggaggct gagcccgccg
1513201 catggctgcg gttctggttc cccgacccga acgggtccaa caccgagttc cagcgcgcct
1513261 atacgatctc cgaagctgac cccgccgcgg gccgcttcgc ggtcgacgtt gtattgcatg
1513321 acccggcggg tccggcctcg tcgtgggcgc gcaccgtcaa acctggcgca accatagcgg
1513381 tcatgtcgct gatgggctca tcgcggttcg acgtgcccga ggagcagccc gccgggtatc
1513441 tgctaatcgg cgactcggcg tcgattccgg ggatgaacgg gatcatcgaa acggtcccga
1513501 acgacgtccc gatcgagatg taccttgaac aacacgacga caacgacacg ttgatcccgc
1513561 tcgcaaagca tccccggctg cgggtgcgct gggttatgcg ccgcgacgag aaatcgctgg
1513621 ccgaggcgat cgagaaccgc gactggtcgg actggtatgc gtgggcgacg ccagaggctg
1513681 ccgcgctgaa atgcgtccgg gtgcggctgc gcgacgagtt cgggttccct aagtccgaga
1513741 tccacgctca ggcttactgg aacgccgggc gtgccatggg cacccaccga gcaaccgaac
1513801 cggcggccac cgaacctgag gtgggcgcag ccccgcagcc agaatcggcg gtgcctgccc
1513861 cggcgcgtgg cagctggcgc gctcaggctg ccagccggct gctggcgccg ctaaagctgc
1513921 cgctggtgct ctcgggtgtg cttgcggctc tggtcacgct ggcgcagttg gcgccgttcg
1513981 tgctgttggt cgagctgtca aggctgctgg tctccggcgc cggcgcgcac cggttgttca
1514041 cggtcgggtt cgccgcggtg gggttgctgg ggaccggggc cttgctggca gccgccctca
1514101 cgctgtggct gcacgtgatc gatgcccgct tcgccagggc gttgcgcttg cggctgctga
1514161 gcaagctgtc ccggttgccg ctgggctggt tcaccagccg cgggtccgga tcgatcaaaa
1514221 aattggtcac cgacgacacg ctggcgttgc actacttggt cacccatgcc gttccggacg
1514281 cggtcgccgc ggttgtcgcc ccggtggggg tgctggtcta tctgttcgtc gtggactggc
1514341 gagtggcgct ggtcttgttc gggccggttc tggtctacct gaccatcacg tcatcgctca
1514401 cgatccaatc cgggccccgc attgttcaag cgcagcggtg ggcagagaag atgaacggcg
1514461 aagcgggtag ttacctcgag ggtcagccgg tgattcgcgt cttcggcgcc gcgtcatcga
1514521 gcttccgtcg ccggttggac gagtacatcg gattcctggt cgcctggcag cggccgctgg
1514581 ccggcaagaa aaccctgatg gatctggcca ctcgcccagc aacgttcctg tggctcatcg
1514641 ccgctaccgg caccttgttg gtagccacgc atcgaatgga tccggtgaat ttgttgccgt
1514701 tcatgttctt gggtaccacg ttcggtgccc gcctgctcgg gatcgcctac gggctcggcg
1514761 gcctacgcac gggacttctg gcggcccggc acctgcaagt cacactcgac gaaaccgaac
1514821 tcgccgtgcg ggaacatccg cgcgaaccgc tcgacggcga ggcgccagca actgtggtgt
1514881 tcgaccacgt caccttcggg taccgccctg gagtgccggt gatccaggat gtatcgctta
1514941 cgctgcggcc gggcacggtc accgcgctcg tcggcccgtc cggctccggc aagtcgacac
1515001 tggccaccct gctggctcga ttccacgatg tcgagcgagg tgcgatacgc gttggtggac
1515061 aggatattcg atcactggcc gcggacgagc tgtacacgcg agtcggcttt gtgctacagg
1515121 aagcccagct tgtgcatggc accgccgccg aaaacatcgc gctggcggta ccggatgccc
1515181 ccgccgaaca ggtccaggtc gcggcccgcg aagcgcaaat ccacgaccgg gtgcttcggc
1515241 tgccggacgg ctacgatacc gtgctcggag ccaacagtgg tctttcgggc ggggagcgac
1515301 agcggctcac cattgcccgt gccatcctcg gcgacactcc ggtcctcatc ctcgacgagg
1515361 ccaccgcgtt tgccgatccg gaatcggaat accttgtgca acaggcgctt aaccggctga
1515421 cccgggaccg caccgtgctg gtaatcgccc atcgactgca taccatcacc cgggccgacc
1515481 agatcgtcgt gctcgatcat ggtcggatcg tcgaacgcgg cacccacgag gagttgcttg
1515541 ccgcgggcgg acgctactgc cggctgtggg acaccggcca gggcagccgg gtggcggtcg
1515601 ccgcagcgca ggacggcacc cgatgatccg cacctggata gcccttgttc cgaacgacca
1515661 ccgcgccagg ctaatcggct ttgcgctgct cgcgttttgt tccgttgtcg cgcgagcggt
1515721 gggcaccgtg ttgctggtgc cgctgatggc ggcgttgttc ggggaggcgc cgcagcgcgc
1515781 gtggctgtgg ctgggctggc tgtccgccgc gaccgtggcc gggtgggtgc tagacgccgt
1515841 gaccgcacgc atcggtatcg agctgggttt cgccgtcctt aaccacaccc aacatgatgt
1515901 ggcggaccgg cttccggttg tccggttgga ttggtttacc gccgaaaaca ccgcgacggc
1515961 acggcaggcg atcgcggcca ccgggccgga acttgttggc ctggtggtta atctggtgac
1516021 accgttgacc agcgcgatcc tgctgccggc agtgatcgcg ctggccctgt tgccgatctc
1516081 ctggcagctc ggcgtggctg cactggccgg cgtgccgttg ctgctggggg cgctgtgggc
1516141 ctccgcagcc tttgcgcggc gtgccgatac cgcagcagac aaagccaata ccgcgctcac
1516201 cgaacggatt atcgagttcg ctcggactca acaggcattg cgggccgccc ggcgcgtcga
1516261 gccggctcga agtctggtcg gcaacgctct ggccagccag cacaccgcga cgatgcggtt
1516321 gctgggcatg cagataccgg gccagctgtt gttcagcatc gccagccaac tggctttgat
1516381 cgtgctcgcc ggcaccaccg cggcgctgac catcacggga acgctcacgg ttcccgaggc
1516441 catcgccctg atcgtggtga tggtccgtta cctcgagccg ttcaccgctg tcagcgagtt
1516501 ggcgccggcc ctcgagagca cccgcgcgac cctggggcgc atcggatcgg tgcttaccgc
1516561 accggtcatg gtggccgggt ctggcacgtg gcgtgacggc gccgtggtcc cgcgtatcga
1516621 gttcgacgac gtcgccttcg gctacgacgg cggcagcggg ccggtcctcg acggggtcag
1516681 cttctgcttg cagccgggaa ccacgacggc gatcgtcgga ccgtctggct gcggaaagag
1516741 cacgatcctg gcgctgatcg cgggcctgca ccagcccact cgcggtcgtg tcctcatcga
1516801 cggcaccgat gtcgcgacgc tggatgcccg ggcgcagcag gcggtctgca gtgtcgtgtt
1516861 ccaacatcct tacctgttcc acgggacgat ccgcgacaac gtgttcgctg cagacccggg
1516921 cgctagtgac gatcagtttg cgcaagccgt ccggctggcg cgggtggacg agctcatcgc
1516981 caggctgcca gacggcgcaa acacaatcgt tggcgaagcc ggctcggcgc tgtccggcgg
1517041 cgagcggcaa cgcgtaagca tcgcacgggc tctgctgaaa gccgctccgg tgctactggt
1517101 cgacgaggcg accagcgcac tggacgccga gaatgaggcc gcggtggtcg acgcgcttgc
1517161 ggccgatccg cgatcacgca cccgggtgat cgtcgcccat cggttggcaa gcatccgtca
1517221 tgccgaccgc gtcctgtttg ttgacgatgg ccgagtggtc gaggacggtt cgatctccga
1517281 gttgctcacc gcgggtgggc gtttcagtca gttctggcgc caacagcacg aggccgccga
1517341 gtggcagatc ctcgccgagt aacgcgagaa accaccgcgc cacgcagata gccacttcct
1517401 ccgtgaatct gcatcgcgag gtcggccacc ttgccagcta gttcggtgta gaagagcttc
1517461 gccgccgacg gtgcaaaata tgatattcgc atggcgtcat tgctgaacgc tcggactgcc
1517521 gtaattaccg gcggtgcaca agggctgggg ttagctatcg gccagcgatt cgttgccgag
1517581 ggtgcacggg ttgtgcttgg tgatgtgaat ctcgaagcga ccgaggtcgc agccaagcgg
1517641 ctgggcggcg atgacgttgc tctggcggtg cggtgcgatg tgactcaagc cgacgacgtc
1517701 gacatcctca tccggaccgc tgtcgagcgt ttcggcggtc tggatgtcat ggtcaacaac
1517761 gccgggatca cccgcgacgc aacgatgcgc acgatgaccg aagagcagtt cgatcaggtc
1517821 atcgcggtgc atctgaaggg aacatggaac ggtacccggc tggcggcggc aatcatgcgg
1517881 gaacgcaagc ggggcgccat tgtgaacatg tcttcggtgt caggcaaggt cggtatggtc
1517941 ggccaaacca actactcagc ggccaaggcc ggcatcgtag gaatgaccaa ggcggccgcc
1518001 aaagaacttg cacacctcgg cattcgggta aacgcaatag ctccggggtt gatccgttca
1518061 gcgatgacag aagctatgcc gcaacgcatt tgggaccaga agcttgccga agttccgatg
1518121 ggtcgcgccg gcgagcccag cgaagtcgct agcgtggccg tgttcttggc ttcggatcta
1518181 tcctcgtaca tgaccggcac cgtgttggac gtgactggcg gccggttcat atgacaccga
1518241 gatcattgcc acggtacggc aattcgtcaa gaaggaaatc tttcccaatg caccggccct
1518301 cgaacgtggc aacagctacc cgcaagaaat cgtcgatcgg ctgggtgtta ttggcttgct
1518361 cggtcgccgg ctgcaagggt atcgacacca ccgagttcat tctcgggcgt gccggcgcat
1518421 tcgagctggc ggtgcgcgct gcccagcacc gtcataggta cttgacgatg gtcaacgtcg
1518481 gacgagcgcc accacgtcgc tgccgaacgg tatgcatggc ggctaccgat actccgcgga
1518541 atatcagatt gaacggctga tgcctgatgc gcccgttgct gctcagcgga gcgggaacca
1518601 gcgcgatcca gaagcctctg aggactcgaa ggctggcctc cggagtccat cgatgatgtg
1518661 cagttgcatc gcgattgccg ccaggggcgt tgtcgcttga gcacatctgg gcataggctg
1518721 ccatcttgga gggcaggcaa cctgcatgat agggaggaga atatggcccg cacgcttgcg
1518781 ttgcgcgcat cggcgggact cgtcgcgggt atggcaatgg ccgcgatcac gctcgcacct
1518841 ggggcccgcg ccgaaaccgg tgagcaattc cccggggatg gggtgtttct cgtgggaact
1518901 gacattgcgc caggcaccta ccgcacggag gggccgtcga atccccttat tttggtgttc
1518961 ggcagggtgt ccgagctctc aacctgctca tggtcgacac acagcgcacc cgaggtgagc
1519021 aatgagaaca ttgtcgacac caacacctct atgggcccga tgtcagtggt gatcccgccg
1519081 accgtggcag ccttccagac gcataactgc aagctttgga tgcggatctc ataggggccg
1519141 gcgtacccgg taccggccgc gggcctacca cgtgccggaa ctggaagcgc agtaagccct
1519201 caacgcgcca ccgctttggc ccgcgcgccc ggcgtaggcg catcggcggt ggccgtgggg
1519261 cggcgcactg cgacctcacc agcggctttc gagctttgtt cgatcaaccg gccagcatgg
1519321 tcgaggatgc attcgagacc atattcgaaa ttggtttcat cgggggcccc gatccgatgc
1519381 cccctcccag ttgcgtgagc aagcagcgga gtcgtcgcgg gatcgatggc cacggggtgt
1519441 tcaatggcgg atggtccgct gcccgccgac tggctcttgc gggagagccg atctagcacc
1519501 accgatccgc gcacgtggac cgaaaccgcc gagtagatgt cgaaagcgtc ttcgagcgac
1519561 aggcccgccg tcaccagatt ggcgatggcc ttctccatct cttgggcgcc caaccgcgcc
1519621 gttttcgggg acagcgccgc tcgaatcagt atcagatcgc acagtacggg gttgtccgcg
1519681 aacgtcttcc gcatcgagcg ggcatgattg cgcaacgttt cgcgccagtc gccggcttcg
1519741 atgtacgggg tagcgaacac gtacttgctc aaagcgcggt cggtcatcgc gttgagcaga
1519801 tcgtccttct tgcggaagta ccagtagatg ctggtgaccc cgacgccaag gtgtttgccg
1519861 agcaatggca tgctcaagtt gtctatcgat acctgctggg cgagttcgaa tgcgccgctg
1519921 atgatgtcct cggggttgat ggatccgcgc tgccgtcgtt gacgcttgcc tggggttgtc
1519981 tgcattgccg ttacggcacc tccatcaaga taacgccggg tcagttgcag gtatgcaggt
1520041 cggcggtagt cgtcgtgcgg acaacatgtg ccgcatggcc tccccgggga caggccggga
1520101 gaacaagaag ccttgcgcac ggtaacagcg ctgatccaat agaattctgg cggcagcctc
1520161 ggtctcgacg ccttcggcta ctacatcgag ttggaagcct tcggcgagtg tcatgatgcc
1520221 gcgcacaatg accagatcgc tagtgttggt tccgagttgc cgcacgaatg ttttgtcgat
1520281 cttgagcgtg tcgatcggta gcgtctgcaa cagtgatatg gcgctatagc cggtgccgaa
1520341 atcgtcgata gcgatgtgaa cgccgacttc tttgagtcga gccagggtgg ctctggcggt
1520401 atgtaggtct tgcaccacaa cgttttcggt gatttccaaa cacacggacg aggcgtccag
1520461 accgtgctgg ccgatcgtgt ctgcgacgaa gtcaacaaac ccgcccgtca ccagctgtcc
1520521 agctgagacg ttgatacgca gcagcgcgtc gtggcccaaa ccggctgact gccactcgga
1520581 gaattcattg caggccctcc gcagcaccca tctatccaat tcgcctgcaa ggttgatgga
1520641 ttcggccaca gggatgaagc agcccggtgc cagcagccca cgggtggggt gctgccaccg
1520701 gaccaatgcc tcggtcccga caatgtcgcc ggtccgtagg tcgacctcgg gtaggtagac
1520761 caggcgaagg gcgtcggatt cgataccacg tcgaaggtgt agttcaatat cgttgcgcag
1520821 ttcgccgctg accgacatgt ccgcggtgaa aatcgcgacg ctatctccgc cggcgtgttt
1520881 ggctgccaga gcggcttggt cggctcggcg caggaggtcc gacggtgtgt gctgtccggg
1520941 agtccctgag gcgacaccga tactgacggt gcgggtgagc acctcaccgc cgatagcgac
1521001 gtggtccttg agctggtcgc gaagacgttc ggcgagcggt tgagcggcat cggcactcat
1521061 tggagatgcg ggtatgagga cgaattcgtc gccgccgagt cgggcgatca ggctctcgcc
1521121 aacgagtgcg tcaccgatcc gttgggcgaa cacatggatg aactggtcac cggcggcgtg
1521181 gcccaggtag tcgttgatgg ccttgaggcg gtccaagtcg agaaatagcg ccgcgaccgg
1521241 gccaggttgt ccgggggcca gtctttggtc caggtgctgc agcaacgcgc gacggttatg
1521301 cagtccggtc agatcgtcat ggtcggccag atagcgaagc cgcgcctcgg cggcgacgcg
1521361 agcctgcacc tgggcgaaga gtgtagcgat ggtcatgagg gcgttaagct cggcctcgtg
1521421 ccatttccga tcaccgaact tgatgaaccc cagcagtcca gtggtgatct cgccagatac
1521481 cagcggcacg gcggcagccg acgttaccgg aaccccgcgg gcttcttcga tgaggcgttg
1521541 atagtcctcg gtggccggct cgggccggaa cacgagaggc tctttggcgt gttcgcatag
1521601 cgcaaacacc gggtcggcat cagcgaagta gatcagcctg agcggatcgg ggtccggtat
1521661 gttgaggcga ggtggccatt cggccaccag cctcgtcgcg cgcctgtcgc gatcgttatg
1521721 acgcaaaaag ctgacatcta cgcccagctg ttccactaga taggccaaaa cgcgctgact
1521781 gacttcggct gacgtggcag cgtcgactgt catgagctgg ttggctacgg tggtgacgag
1521841 ctcctcaagc tgcggcgtcg cggtgtcgtt gcacatctcg gatgctatct gtgcggctct
1521901 ggtatggcgt gccgtacgcg tcggcggcta cacaccgacg gcggtggcgc gtggaacaac
1521961 ctgaagatca acacctcgtg cccttctttg cccggcttga ccagttcccg aaagtcgagt
1522021 tgcaggcggt gcagctgtgc ggcgaaatgg ggtgacgctt ggtcgaggtc gtggcggcca
1522081 cgtgcataca ggaagatcgg tgacatcggt tgtacggcca gtccatgttg ttgggccaca
1522141 atccacaccg cctgcatggc tgatccgcca cgcgcaaaat cggtgagcgt ggcgccatca
1522201 acgtagacga ttgcgagcgc tgaactcgcc gacacgcgct cattggtgtt gtcttcgagg
1522261 gctgttccgc aatcccattg cgctagccgt gccacgacgt cggagcgtcg caggatatcg
1522321 agaacccgca attcgccgga atccagttcg aggcttcgga catcgatgcc cgcatcgagc
1522381 gaagggtcgc ccggccaccg gagctcggac atcatttcct catgtagcct cggggtgaga
1522441 tagcggattc ggtctgcagc cgctaaaatt gttgcagccc ggtcgatctc gtttcgtgac
1522501 agcaacagct gtaaccgcgc accctcagcc gcggcggtgt tcgttaacaa ctcaacggtc
1522561 gcggggtgga cgtgaccggg cataccgtgg tggcgattgg tcgttctgag cagcatcggc
1522621 cggtaaaggg ccgcaaggct tggatcatca ccacggccaa aatgcattgt cgcttgcagc
1522681 ggcgagtcgg gctgggattc gtcgaactct actgatccca ggacccggtg tgcagcggca
1522741 gcgacacgcg cgttaaacat ggccgcgccg acggccactg cgctaccacg aaacgcgata
1522801 tccattgcgc tggtgtgctc aggtgctagt cggatggtca gcgaatgctg tttggccaca
1522861 acatgccatg gctgaacgtt gccccctgaa ggcgcgcgaa tcgccgcctg agccacgatt
1522921 tcgctggttg gctgcggctc ggctggcgct gttggcggca cggactcgag caaccatccg
1522981 ttcccgcgag acggcatggg cggttgatcg aggcgatcta gcgctgcgga cacatccacc
1523041 cgtacccggc cagactcaag tggttctccc agaccgattc tgcgtaccgc ttcagctacc
1523101 gtcgctgcgc ccacccagat atcgcctgcc aactgcggcc atccccacaa cgtctggtca
1523161 acttcgatca tcgaagccgc acaacgcgcc gagagctctt ggcaatcaag gatgttgaga
1523221 acgtggggga ctttgtcttt tgtggtcagt ccacacagct tgtcggcgtc gatgtcgccc
1523281 aatagcccat gaaagatcgg tcgcccaggt tcgacgtcgt agcgttcgac atcgaccagg
1523341 ccgcggtcac tggtcgccat cagtacgggg acaccacggg cgcacgcggc ttgtcgcagt
1523401 atcactttga tatccagcga gtcgcattct tcgataacga cgtcaaggcc gtcgaggaac
1523461 tcgtcgacgg attccggcga gagcccggat gtaacgaggt ccacggccag gtagggatcc
1523521 agctccgcga tcctgcgcgc cgcaatcatc gccttgttga ggccaatgtc gaagacgccg
1523581 accggcacgc gattcaggtt cgacagctca attttgtcga aatcggccaa ccgcagtgtg
1523641 ccacaggcac cttcggcggc aagggtgtat gcgatcgcat ggccggcgct gagtccgacg
1523701 acgccgaccc gtagcgcgtg cagtgcgcgt tgttcctcag cggtgatgag gtgcctgttg
1523761 cggtccaagc gcacggcacg gaacccccgg agacccagaa tggcaacaac catgcgccgc
1523821 cagggataat aggcccatcg cttcgcttct tctagcagat ctggatcagg ctgtggcagc
1523881 aggcgccgca cgcccgctag ctgttctgcg aatcggtcga cgaactcgat gctcggatct
1523941 gagcgtagtc gatcgagcac caggacatcg tcgtggtcat cgtcacgaag gacgagaatg
1524001 ccggtgctgc cgccctcgtg tgggatggtc actgttcggc tccagcggtc gctgcggtgg
1524061 ttgcgctcaa cgcttctaca tcgcgcagaa gcttgcgcga ctcgacaagc attcttgaca
1524121 gttgttttgg ctcggcatgg ttagccaagg ttctgcggtc ccaccagatc atcttggtcc
1524181 ggtagcgctc gtccgggtat gctgccgccg ggattctcgc tgctattact ccccccgaag
1524241 aacgccaccg gtccagcgcg tgggccgccg cggtccccat cacaaactga acccccaaca
1524301 gggacatgct tagcggtagg gcgcgcgcca aggcggcagc aatcgcatca ctgcgctgcg
1524361 cgtcactatt aacccacccg gacttcactt ccacgacccc gaatggcgcc cggtcattga
1524421 tcatcttgcg caccgcggat aatccgggat tgccagccca ttcgactacc gcatgcgagt
1524481 catcggctga ccgcagcggt ccgattaccc gagcgccccc gactacatct cctccaatat
1524541 caatggcggc aaagaacaac tgtgtatcgg aaccgtcact gatggcgtcg agatctaagg
1524601 tacactcgac tccgtgctta ctataggcgc gaagcgcacc ctgaaggtat gtattccaca
1524661 acgtgggatc gagcgcgggt tgcgatacca caagccggca ttgcgcatca gaaacccaca
1524721 cactgagatt ttccgaaaaa tgcaacttct gcggtgcgat aggacgaagt tgagcggtgg
1524781 tcatgattct ccaatctgtt aggtatccgg caattaacac gagatttgct gcccctgtat
1524841 cgagcagcgc agacgttggg gctgcgcccg gagaattgct gccgttgcgc agaacggcgc
1524901 cgcacggcag ggttcaacgc ccggccgcgc tggtatttat cgagtcgctg cgagagccgt
1524961 gaacaaattg tcacgaaatc gtgcgcacgc gcgttcacaa ataccacgcg cacgcgctcg
1525021 aaaactacat gaccagatag ccagattttt ccggaccggc aaagcgttgt tcagtgttgg
1525081 tcacggctct tgatcgtatt taccccgggt ggcgtagacc ctatcgatgg tggaccccgt
1525141 tcatcggggt aatcgaatgg atcatgcaaa atattacttt gacgagtatt cattccgatt
1525201 caaccggtcc cacccacctc tcatgcgtgc ggggcatact gttctacggc ttggtgaaac
1525261 acgccgttgc catcgatcta cacccacgcg acctactctc tgaaaaagtc gaccggcagt
1525321 gccttggcaa agtgccagcc ttgtgcggct ttacagccga aggcgcgcaa ccgggcggct
1525381 tggctggggg tttcgactag ctttgcagtg acggtgatac cgagcttgtc gccaaggtcg
1525441 atcattgccc gggtgatctg ttcgttggcc agccgagctt gaatgtcgcc atcgaggcac
1525501 tcgatgaact ttcccccgag tttgaccacg tcgacgggga ggcggggaag gtaggcgagg
1525561 ctggagaatc caatgccgaa gtcgtcgatg gcgatgccga cgccgagagc ggacaattct
1525621 tgtagcctgg tcaccgcctt ctcgtctctg ctaaggcgcg cgtcctcggc cagttcgagc
1525681 tgcagggcat gggcgggcag gccggtttcg ccgagcacac cttcgaccag caccaggaag
1525741 ccgggatcgc agatggtgct ggcggagacg ttgacgctga caaacggttg cgggtcggtg
1525801 ctgtggtcac gccaactgcg gacgtggcgg caggcctgct cgagcacgaa ggccgtgagc
1525861 ggcaccatca gtccgttgtt ctcggcacgg tcgatgaacc ggcccgggag tagcgtgccc
1525921 aacgtcgggt gttcccagcg cagcagggcc tcggcgccga tgatgcggtt gtcggcaagc
1525981 cggatgattg gctggtagac gaggaagaat tcaccgcgat ccagtgccac gcgcatcgaa
1526041 gtggacagat aatggcgagt gttgacctgg tcgcggtcgg agtccgccca ttggtcagga
1526101 ttggctacca tcgctcgcgc ttgcatcgcg cccctaaaca tctcttcgta gtcgatcaac
1526161 ttggtcggcc tgagcgcgca agcgaacgct gtagcgcgct gacaacaacg atccatccaa
1526221 gggctgcatc aggattcaca gcccggtggg cacctcgccg accgcggtgg caacgcgaag
1526281 cacaccaccg aagtcgtctt gacccgaacc gtcgcagtag attctggagt cctgggaggc
1526341 aaagatcgtc agcgataatg cgtaaaagtc cgtcacgtac tacgtagaag gtccgtgagt
1526401 gcagccgttc cgggcatgca cgaaccggcg cttacacgtc gaaggcggct gcgcggcaat
1526461 cagtctcggt gggtaaccca ttgtcggcgg gcgatcggtt acctctcgaa tcgacggccg
1526521 cccgcatctg agttagccag gccagcggtt tcctacgggc gctgggtgca aagatacgac
1526581 ttccgggtgc aatagttacg cgctatcgct gatgttcttg tccgcaccgg ccttcagagt
1526641 tgagccaacg cgtagtcgcc actcggcact acggtgggcg cgtcatcgac gcttcgctga
1526701 cggcccgagg tggcagatgt tgcgctcgct gcagatcgcc gatcaaatcg ctcgtacggg
1526761 tcacatgcca gtgaggcgtc ttgatctgat ctggatcagc gcacgaaacg ccgcgagacg
1526821 ggagcttgat ctgggcgtgg ctgcgctggt ggaggctgtg acgttgctca ctgctgacgt
1526881 cgagggctcg acacggctgt cgcagacgcg actcaacgag ctagcggccg attacccaac
1526941 cttggatcag aacatatcgg aagctgtcgc ggcccatggc ggggtgacgc gaccggtaga
1527001 ccaggaggtg ggtagcggtc tcgtcgtcgc gttcctgcgt gctggcgacg cgatcgcgtg
1527061 cgctttggaa ctgcagctct caacgttggc gcctatgcgg ccgcgtgtcg gtgtgcacac
1527121 cggcgatgtc cggctgcgcg gcgacggcac catcaccggc tccgcgatca acgagagtgc
1527181 gtgtctgcgc gacctcgcac acgaaggcca gactttgctt tcagccgcca ctggcgatct
1527241 ggtcatcgac cagcttccgg caaatacctg gctgaccgac gtcggcaagt accccctgcg
1527301 gggtttgcat cgccaagaac gggttatcca gttgtgtcat cgagacctac gcaatgagtt
1527361 tccgccgctg cggatgtcgg tcggtaacag atccagcctt ccggcccagt tcaccacttt
1527421 tgtaggccgt gacgcacaga tcaacgaggt gcaagaggtc ctgacgaact accggctggt
1527481 gacgctgcgc ggcgagggcg gtgtaggtaa gacgcgtctg gcgatccaga tcgcggccgc
1527541 gtcggaattt cgcgatggtc tgtgtttcgt cgacttggca ccgattgccg atcccggcat
1527601 ggtgtccacc accgcggccc atgctctagg tctgatcgat cggccgggca gctcaacatt
1527661 cgacactctt agtcatgcca tcggcaactg ccacatgcta atggtgttgg acaactgtga
1527721 gcacgtgttg gatgcgtgcg ccgagctggt cgttgagctg ctgggtgcct gcccggagtt
1527781 aagcattttg gcgaccagcc gcgagtcgat cggcgtgacc ggcgaggtca catgggtggt
1527841 gccgtcgttg tctccggcga acgaagcaat ccagttgttc actgaacgtg cgcgcctagt
1527901 ccaacccaat tttgagatcg ttgctgacaa cttcgacgcc gtgagcgaga tctgccggcg
1527961 gctagacggt atgcccctgg caatcgagtt ggccgcggca cgattgcggt cgttgtcgcc
1528021 aaacgagatc gccaacagtt tggatgaccg attccgcctg ctgaccggtg gtgctcgcag
1528081 tacggtgcag cgccagcaga cattacgggc atctatggat tggtcgtacg cactgctgac
1528141 tgacaccgaa cggatcctgt tccgccgcct tgcggtgttt gtgggcggtt tcgacctcac
1528201 cgcggcgagc gaagtcgccg ccgccggcgg cgacgacttc gtcgagcggt attcagtgct
1528261 tgatcaactg acgctgcttg tcgacaagtc gctggtggta gccgaagaaa gccgaggcag
1528321 tacgcgctat cggctgttgg aaaccgtacg ccagtatgcg ctagaaaaac tgaacgaatc
1528381 cgaagaaatc gacggggtgc gcgctaggca ccggacccac tacgcaacca tggcggcagg
1528441 gctgaacgtt cccgcctcca ccgactatga acaacgcctc ctgcaggctg aagccgaaat
1528501 cgataatttg cgtgccgcat tcacctggag ccgtggaaac ggcgatattg cagccgcatt
1528561 gcagctcgca tccgcattgc aaccgctgtg gtcgcagggg cgcatgcgcg aagggctggc
1528621 ctggctcgaa tccatcctcg agcgggaagg cgacaatcat cttgtgccgg cgggggtttg
1528681 ggcgcgggcg cttgcggaga aggtaatact caaggcttgg ccggccacga gcccgatggg
1528741 cgcccccgac atcgtcgcgc aggctcacca tgccttggcg ctggcacgcg acgcaggcga
1528801 ctgcgcagtg ttggctcgag cgctcgtcgc atgtggctgc ggcagtggtt gcgacacgga
1528861 agccgctcaa ccctacttcg ccgaggcgat cgagctggcg cgcgccatta acgatgagtg
1528921 gacattgagc caaatcgatt attggcaggt ggtcgggatc ttcatatcgg gtcagccaat
1528981 tcctttgcga gctgcggccg aacaagctcg agagctcgcc gacagcatcg gaaaccggtt
1529041 cgtctcacgt caatgccgcc tgtttgcctg cctggcgcag atatgggaag gcgacgcgaa
1529101 cggagcattg gcactatctc gcgacgttac cgccgaggcc gaggtggcaa acgatgtcgt
1529161 tactaaggta ctcggtttgt atgtcgaagc catggcactg tcttacatcg gcgacagcgc
1529221 cgcccggacc atcgctggtg cggctctcga agctgccacc gagttaggcg ggatttacca
1529281 agatctgggt tacggagcga taactcgcgc ggcgttggcc gcgggcgacg tagcggccat
1529341 tgaggctagc gaagcgagct gggatcttcg caatcaacac aacgtggtaa cggcacacca
1529401 cgagctgatg gcgcaggcag ccctggttcg cggcgatgtg accacggcaa gacgtttcgc
1529461 cgacgaagct gtgcttgcga gcaccggatg gcatctgatg atggcgctga tagcacgggc
1529521 gcgagtggcg attgcgcagg acgagctggg aaaggcacgc gatgacgccc acgccgcggt
1529581 ggcgtgcggc gtcggtgtgc agacgtacct cgcgatgccg gatgccctag aacttctcgc
1529641 aggtctggcc ggtgaggccg gtaaccacgg tcaagcagtg cgccttttcg gcgcggccgc
1529701 ggcccagcgg cagcgtacgg gggaggttcg ccacaagatt tgggacgccg gctatgaggc
1529761 cgccacggcg gcgcttcgtg atgcgatggg cgacgaagat ttcactgccg cctgggctga
1529821 gggtgccgcg gcccccttgg acgaggcgat cgcctacgca caacgcggtc gcggcgaacg
1529881 caaacgccca agcaacggct gggacgcgct gaccccggcc gagcacaaaa tcgtaaagct
1529941 cgtcaccgaa ggactggtca ccaaggacat cgccgcgagg cttttcgtct caccgcgtac
1530001 cgtgcaaaca cacctcaccc acatctacac caagctcgac gtcacctccc gtgtccaact
1530061 tgtacaggag gccgcgcaac actcgaccta ggattgcgcg gccagcgcag gcccggagtt
1530121 cgaatcggat gcaatacgca accaatctgg gctcttctgc gcgttgtcgc tgatgttcat
1530181 ggctcttcgc gcccccatgc ttgagcgcat gaacggtttg catacagatg acgcgccggt
1530241 caattggctc gagcggcgag gtggccggct tacgtcgagg cggagggtga cgttgctcca
1530301 tgctggagtg gaacacccga tgcggctgtg gggcgtccaa tccgaggcga taactgccgc
1530361 gatggtgctt agccggaagg tatcggccat cattgccgga cactgcggtg tgcgcctagt
1530421 tgatcagggc gtgggcgatg gcttcgtcgc cgcgttcgcc catgccagcg atgccgtcgc
1530481 atgtgctctg gagttgcacc aggctccgtt gtccccgatc gtcctgcgca tcgggattca
1530541 caccggtgag gcgcagttgg tcgacgagcg catctacgcc ggcgccacaa tgaacctggc
1530601 tgcagagcta cgggatttag cccatggtgg gcagaccgtg atgtcgggtg ctaccgagga
1530661 tgcggtactc ggccggcttc ccatgcgcgc ttggctaatt ggcttgaggc ccatggaagg
1530721 gtccccggaa gggcataact tcccccagtc acaacgcata gcacaattgt gccatccgaa
1530781 ccttcgcaac acctttccgc cgctgcgcat gcgcatcgcc gatgcgagcg gaattcctta
1530841 tgtggggcgg attctggtta acgttcaggt agttccccac tgggaaggag ggtgtgccgc
1530901 agcggggatg gtccttgctg ggtgaagcgc cattgagggc cagacgatag gttggccagc
1530961 gacgtcctca actcagactc tcggcgcgac ctgaccggcg gttacgatca tctgctcgga
1531021 cattcgcaag agagcgtgct cgcccactcc ctgcggcaag gtgtaggcca gctcgcgcaa
1531081 cttaaccgcg cactcgtaga gcgtctggcg gaaatgcgtt tcggtcatcg gggtgccttc
1531141 gctcgtcggc gagatcggca gcggtgtctt gtgctcatac agatcaatct cattcatcag
1531201 agccatcatt cgccggctag cagctgcaaa tcatcagcac atccacgtat gtcgtcggct
1531261 gcccagcgcg caatgtgtgg cacggcgagt tgatgttcaa cctcggcgtg tcctgcatac
1531321 tggatttctt actgtaaagt cacccaaatg ggtggtgccc gccggctcaa gctcgacggg
1531381 agcatcccca accagctcgc ccgggcggcc gacgcggccg tcgcacttga gcgcaatggt
1531441 ttcgatgggg gctggacagc tgaagccagc catgatccct ttctcccgct gctactggct
1531501 gccgagcaca cgtcgcgact tgagcttggc accaacatcg cggtagcgtt cgcgcgcaat
1531561 ccgatgattg tcgccaacgt gggctgggac ctacagacgt actcgaaggg aagattgatc
1531621 ctcggtctgg gaacccagat ccggccgcac atcgagaaac gattcagcat gccctggggt
1531681 catccggcac gtcggatgcg tgaattcgtc gccgcgctgc gtgcgatctg gttggcttgg
1531741 caggacggga ccaagctttg cttcgagggt gagttctaca cccacaagat catgaccccg
1531801 atgttcacac ccgagccgca gccctatccc gttccgagag tcttcatcgc cgctgtcggt
1531861 gaagcgatga ccgaaatgtg cggcgaagtc gccgacggcc acctcggtca ccctatggtc
1531921 tcgaaacggt acctcaccga ggtgtcggtg ccggcgctgc tacgtggcct ggcgcgatcg
1531981 ggtcgcgatc gcagtgcctt cgaggtgtcg tgcgaggtga tggtggccac tggcgcggac
1532041 gacgccgaac tggcggccgc ctgcactgcc acgcgcaagc aaatcgcctt ctacggatcc
1532101 acgccggctt accgcaaagt cctcgagcag catggctggg gcgatctgca cccggagctg
1532161 caccgcctct ccaagctggg tgagtgggag gccatgggtg ggctaatcga cgacgagatg
1532221 ctcggtgctt tcgcggtggt cggtccggtg gacacgatcg ccggtgccct tcgcaatcgt
1532281 tgtgagggcg tcgtcgaccg cgtcttgccg attttcatgg ccgcatctca ggagtgtatt
1532341 aacgccgcac tgcaggactt tcgccgttga gcgcgccatc ggtggatgag gccaccaaga
1532401 tcgctgcccg catagagggc ccgcattgcg tgcggatcgg cgttacccgg cggcgggcac
1532461 acggggcatt acgtacgccc gcggcggcat ccgcaacgca ttgctaaccc cgccgaaccc
1532521 gccgccgcta ttggtcagtt gccccagcgg tagcccgccc agcatgtgtc cgggggcggt
1532581 ttgggcggcg ctggtcaggc tggtcagcgg cagcgcccgc gccgccgggg tgaccgcctg
1532641 gttggccgcg gcccaggcct gcggcaccga caacgaaccg accgaggccg cccgacccaa
1532701 gttggcggcc accccagcgc ccagacccga agaacccagc gacgaaccca gctggctgcc
1532761 cagcgagctc atcgcctgga ccccgttttg cgccgcggtt tccacggcct gagccgccgc
1532821 cggagcaaag cccttcaaca tcgagtgcaa ggtgctggcc atcgacacac ccgagttggt
1532881 catcgacacg tggttgttga gcatcgacac gatgttgctg agcggcgaca gatgcggcga
1532941 gatggctttc cagagttcac tcagttggtc gaacggccag atgcttttcg tgggctgggc
1533001 cagttgttgc agcgcttggg gcacattgtt catcaactgg ttcgccgcgg cggtgtcgat
1533061 ggcctcctcg accgcgacgg cctgctcaag gagcccgccg gggttggtga tcagtggggc
1533121 gtcctcgaac ggcagcaacg cctcggtcgc cgtcgccgcc gtggcggcgt agccaaacat
1533181 cgcggcggcg tcttgggccc acatctcccc gtattcggcc tcgttgaccg cgatcgccgg
1533241 ggtgttttgc cccaagaggt tggtcgctat cagaatcatc agttcagcac ggttctcggc
1533301 gatcaccggc gggggcaccg tcagcccata cgccgtctcg taggccgccg cagcaacccg
1533361 gacctgggcg gcggtcagct cggcctgccc cgcggtgacg ctcatccacg ccacatacgg
1533421 cgaggccgcc gccaccatca gacccgccga cgaacctatc cacgatcccg tcgtcagacc
1533481 ccagaccacc gactgaaacg ccgacgcggc cgaaaacagg tcactcgcca cgctgtccca
1533541 catcttcgcg gcggccacca gcgaggccga acccgggccg gcgtacatcc tcgcggagtt
1533601 gatctccggt ggtaacgccc cgaagtccac cacttcgata atccttccgc tcggccataa
1533661 ctagcaccaa tgatggacag caaacaacgt cggcaacagg tcaaattctc tcaagtagtc
1533721 acaaccccag atgcaaagtg caccagccgc cctgccgcga agctaaatcc agctgaacaa
1533781 tctgaacatc aggtaaatac agtggcaact aatcttaaat aacccggccg attagacagc
1533841 ggccgagatc tgtttgaggt cgggccgtga ttgtccggag aacggccggt atctcgcacg
1533901 agcagccacc cgcgcccccg tcagacttgg cgaccgccta cggcaaccta aaccggggtg
1533961 aacttggtga tcagccaatt gccgtcgacc ttggctaggg tcaccatcac gctgctggcc
1534021 gccatcgacg gattggggct gtccttactg gtagtgctct ggtcgacaaa aaccagaacg
1534081 acggccgaat ccggatgtag ctccgacacg gccgcgcgca ccaccttggc ggtggttttc
1534141 agtgacttct gtttggccgc cggagccacg atctgctgcg tgaactggtc gtagtaggac
1534201 aggaaatcgc cggcgaggtg cgacctggcg gtagcgaagt cttggtcgag cgtgtcgggt
1534261 gaatacgaca acagcgcgat tgtcccgtca gacgccgcgg cgacggcagc acgggcggcg
1534321 ccggagtccg tctgctgatc gggtcggtat tgctcaaggt atagccatcc cgtcgcgccc
1534381 ccagagatca acatgagcag gatgagaatc accggaacgg gtttcaaggt aacctgcatt
1534441 cgccacaggt cacggtgccg ctgacccttc tgcgcggtag attccgttgc agagtcggtg
1534501 tcaaatgcct cggtcgccga atcaccggct tcgcctgcgg ctgagtcgat ctcagcgact
1534561 tcggtggcgt cagtggtttc ggtgttgacg tcgcgtacgt catcggtcac ggtacgaact
1534621 caactttcga catcttgtac tgtcccccct cttcggtcac ggtcactttg agccgccacg
1534681 cacgtggttc gtctttcgcc ccagcggaat tggtgacccg tgaagtcgcc gcgacgagca
1534741 ccacggcgga atgctcgttc atggattcga cggctgtcgc gttcaccgtg ccttcggtga
1534801 ccactttgga ctgttcgaca accttggtga aatcggctgc ccgctgctgg aagtcatccc
1534861 tgaattcgcc ggtggagctg tcgatcacac gcgcgacgtc ttctttggcc ttgttgaagt
1534921 ccagcgaggt catgttgatg acaccttgct tggctccggc ggcgaacgcc gcggcgcgct
1534981 gctggcgttc ggtggcctca tggtgttgcc acacaatgta tccgctgagc ccggtgaagc
1535041 cgcagatgat gacgactgcg gccgccatgg caatcgtgga cagtcttggt aaccgcaccc
1535101 gcaaccgccg tcgccaggat gccgaccgtg cggcctcctg gtctgcggcc tcatagtcgt
1535161 catagtcgtc atagtcttcg gcgtcttccc agtctgcata ctcctcgggg acgttctcgt
1535221 cctcggctgg ggccatcgcc agcgcctcac gcttcaaccg ggcggcacgg gcacgggccc
1535281 gcgccgcggc ggccagcgct tcggcttcgg cggcttcggc ttcggcggcc aacgccatcg
1535341 cgtcggcttg cgatgtcccc gcgtccgacg gtggttcggt tgtctcagcc atcgtggata
1535401 cagcccgtca gtatcattct cgactgaact ccggtatcgc tcacagtatt gcccattgct
1535461 aacattcgag gccccagcga actcctacga ggaccgatca ggcagacgat cacccacctg
1535521 agttttcccc ggcagcatga ctggtgttga ctctctcgaa aacatactct ttacttcgac
1535581 cctccaagcg tttctccaaa agattcccgg ttgtgccatg tcgtgtcgtg aacgcgtgca
1535641 ggcgatggtc gacggaacgc ccgtgcaggc tcgttgagcc gcctactcct gggcgaagat
1535701 gtcctcggtg tcggcgccga caacgggcag ctggaccagc gacaagacat ggtgcgccgg
1535761 gctgccgggt ggggccacca gcacgcactc ggtcccctgt ttgcgtgccc ggtcacaagc
1535821 ggcagcgagg gcgccgacgc cggccgaacc aaggtgggtg acggcactga ggtcgatcgt
1535881 cacgggtgct atgccagaac ggctttcgac ggcgatctgg cggtccaatg tggctgcggt
1535941 ggtcgaatcg acgtcgcccc ggacaacgat gcggccggat tcaactaggg agacgaattc
1536001 gctgtcgatg gtttgttgga aagctgcccg gcgaaccatc gtgtcggtga caaaccgcgc
1536061 cggccgcgac aggcgatgcg taagtgtggc agtcgttccg ccggcgccat gcatgatgcg
1536121 cgcctccgac actagggcct cggccatcgc caggccgcgc ccacggccac gggcgccgtc
1536181 gcggtggtcc ttccattggc cccggtcgat taccgatgcc cgcacgttgc cgtcgccggc
1536241 cagcgcggcc gcgacaacga tgcccttgga gacgtccgtg gcgtatccgt gttcgaccgc
1536301 gttctcgacg aattcggaga tcgcgtgcac gatatcggcg atgtcggagt ggtcggcgcc
1536361 gatctctgcc agccactcac gaagctgggc tcgaacggtt cgtgccgcgt tgatcgtcgc
1536421 atccagcgtt atgtgcagcg gcggcgttgg cgcccggcgt tgcatcgcaa gcagggtcac
1536481 atcgtcgttg tagccggtgg accgcagcag caattcaagt gtgtccgaac agagtcggtc
1536541 gatgggccgt gccggggcgt cgagcacaaa gccgccactg ccgctggcga tgctggccgc
1536601 taggtcggca aattcggcgg tgctggcctc gagcggccga ccgggccgct cgatcaggcc
1536661 gtcagtgtaa aagaggatcg cgtcgccgat gttgagcact tcactgcgca ctggaaatcc
1536721 ggttccgctg ccgagcggac ccgcgccggt tggttcgaca taccgcgcac tcgcgtccgc
1536781 ggtcaccagc agcggtggcg ggtgtccggc tgtgcagtac tggaattcgc ccgaggtgaa
1536841 gtcgagcgag ccgacacaca tggtggccga tttcgatcca ggtacctgtt tatggaagcg
1536901 gtccactgcc tcaagcgcct cgacgaccgt gtaccccgcc gagatctgca tgcgtaacgc
1536961 cgtacgtaat tgcgacatga ccgctgcggc ctccacgccg tggcccacga cgtcgccaac
1537021 gacgagcacc aaccgatccc cgagggccag cgcgtcgaac cagtcgccgc cggccgcggt
1537081 atcctcggcg gcgaccaggt actcggcggc tatgtcggcg ccgggaacca cgggcaccga
1537141 cgcggccagc aacgcctgct gcataacggt ggctgaatcg cgcacattgc gatagcgctc
1537201 ggacagttcc tccacgcgcg cctcggccgc ctgccgggct cgcactcggc tggtgacgtc
1537261 gtccacaatg agctgcacgc cctcgatcga tccgtccgcc cggcggcgcg gtgtgacgac
1537321 aaagtcgaag tatcgttcct caactccgga accgtcgtaa tcagtttgta gtcgccactc
1537381 cgatcctgat tgcggctcac cggtttgata gacccggtcc aacatttcgt agatctgctg
1537441 accctccagt tcgggataga cctcccgagc gggctgtccc acggtgtcaa gcaatggact
1537501 gaagccgcga taggccgcgt tcactgcgac aaagcgatgg tcaggcccct cgaggccaac
1537561 cagaatcgca gggatgtgct cgaaaatgcg tcgtacatcc tcggccgcac cgaccgtttt
1537621 gtcccagtcc atttcggccg ccatttggcc gtccctccta cggaccgatg tagcaaacgg
1537681 gtcaacgtgc gcagaccaat tcgccaggca acgcaaccag gttatcaacg tgccctacca
1537741 gcttgccgga aaagcaaaag tgcgtttggg gcaggccgcc acttatgtcg ctgacagcgc
1537801 ggactccgtg gtcgggtgta cgggcagcac gtcgccgtat ccgcaggcgt ggatgatgcg
1537861 cgcgacagca cggtcgcggc ttaccaggcg cacgtccacg ccccggcgtc gacaccgttc
1537921 ggcctcgtga gcaaggacgg cgactgcgca gcagcccatg aaatcgaggc cgttgaggtt
1537981 gaccacgagt ggttccggcg cggtggtggc cgcggccgcc ttcgtgacca gatcttgcca
1538041 agtgtgctca ttggcggcgt cgatctcgcc acgcgcatgg ataatcacag ccgagtcgtg
1538101 gtgctggatg gtcgccttga gcgcgttgct caccggagta gtgaatgacc ctgcctgagt
1538161 cgggttcatg gtgcactcct catcggcggc acccgagccc ccaattggat tgccggtcct
1538221 gcgcgccgcg gaaaaccgtc gtctttgtat agcaaggccg gcccgctccg tctatagcgc
1538281 cgaagccggc ggccaatgag cttctcggcg tcctcggagc cgaccccatt ctccgcgcgg
1538341 gtggccccgc agatgcgatc cagcaacccc gccgactcgc tccggacagg tggtggtagc
1538401 cctcgtaggc tcagcaatcg tggacttgca ttcacgacca ccgtggtcga acaacgcggt
1538461 gcgtcgtctt ggcgtggcac tgcgcgacgg agttgacccg ccggtcgact gcccgtcgta
1538521 cgccgaggtg atgctgtggc atgcggactt ggccgccgaa gtccaggacc ggatcgaggg
1538581 ccggagttgg tctgcgtcgg agttattggt tacctcacgt gcgaagagcc aagacaccct
1538641 gctagcaaag ctgcggcgtc ggccttacct gcaactgaac accatccaag acatcgcagg
1538701 tgtccgcatc gatgccgacc tcctgctggg cgagcagacg agacttgctc gcgagatcgc
1538761 cgaccacttc ggtgctgacc agcccgctat tcatgatctg cgtgaccacc cgcacgccgg
1538821 ctaccgggcc gttcatgtct ggcttcggtt acctgccggt cgtgtcgaga tacagattcg
1538881 caccattttg cagagcctgt gggccaactt ctacgagctt ctcgctgacg cgtacggtcg
1538941 gggcatccgc tatgacgagc ggccggagca gctagcggcc ggcgttgtcc cggcacagct
1539001 tcaagagctg gtaggggtta tgcaagacgc ttcagcggat ctggcgatgc atgaagccga
1539061 gtggcaacac tgtgcagaga tcgaataccc cggccagcgg gcgatggcgc ttggcgaggc
1539121 gagcaagaac aaggcgacgg tgctcgcaac gaccaagttt aggctggaaa gggccatcaa
1539181 tgaggccgag tcggcagggg gaggtgggtg aggtggctgg ctatgtcgtc gaatacaacc
1539241 ggcgcaccca cgtgcgtcgc atcaccgagt tcgccacccc gcaagaagcg atggagcacc
1539301 ggttgaagct ggaagccgag cgcaccgaca gcaatatcga gatcgttgcg ctcgtcagta
1539361 agtcgttggg aaccctgaag caaacgcatt cgcggtactt cactggtgaa gagctgaacg
1539421 tcggaaacgg cgcgcggtag gcccttgggt ttccgcgagt gtgccgggtc cggtcgacat
1539481 ggggaggttc ggtcaacatg tctacccggc actagagccc gagcgcccga taggtgcggc
1539541 ggacgaattt tggttgcgcg gtccgcagtt tcgccaggga tgggttaccc gcgacggccg
1539601 cggcagcgtc cacggacaga tcgggacaat gctggatcag atacagcagt atcaggtcgg
1539661 cgctcgggtc ggcctgccac catgtcccgt acgcgccggg ccagctgaag gtcccgagcc
1539721 cgcccggccc gaacagcggc ctggacttcg ccggatcggt caccaccgat aggttcagcc
1539781 cgaagccgcg gcccacccag aacggcgccc ccagaaagct gtgccgtttc tgctcgtcgg
1539841 tcagccggtc ggtgcgcatc aggcgcaccg attcaggtga caacacccgg accccgtcga
1539901 ccgtcccgtc gcccaacagc atccgcacga accgcaggta gtcatcggcg gtcgaccaca
1539961 acccgccgcc ggcgttacag aacgacggcg gcgtgacgtg tggcggcccc atcacgtcgt
1540021 gccgcaaccg gtcttgttcg tcgagccggt acatggtcgc ggcccgtcgc tgcgcgtcgg
1540081 ccgacacgta gaagccggtg tcggtcattc ctgccggacc cagcactcgc tcgtcgatga
1540141 tctggtacag cggtgcgtcc tcgatgcggg agacaatgac acccaagacg tcgatggcgt
1540201 ggctgtaggt cacccggtcg ccaggttggt gcacgagcgg aagggttgcc agcgctgcca
1540261 gccaaacgtc gggaccctgg ccgaacggca gtcgctgata ggcccgcgaa attggccccg
1540321 acaccgagaa accgtaagcc aggccgctgg tgtgagtgag caggtcctcg atcaaaatgg
1540381 ctcgtcgcgc gggatgtgtg cgatccagcg ggccggcggc atcgtccagc acggccacct
1540441 tgcagagctc cggtgcccaa cgcgtgatcg ggtcacgcag tgccagtttg ccctcgtcga
1540501 ccaggctcat cgccgccgcc accgtgaccg gcttggtcat cgacgcgatg cgaaacagcg
1540561 tgtcgcgttg catgggcacg cccgcgtcga tatcgcgata gccgatctcg ttgacttgca
1540621 acaatttttc gcgctgccag accatggtta ccgcgccgga aagcaggccc gcgtcgcata
1540681 cctcgcggat ggacgcctga ttgccgtcga gattcacccg gttcaggata ctgtccgagc
1540741 cagcgcggct cggcggatta ctgattgtgc gaacgttttc ccgcgcaccg gtcgcgtgtt
1540801 actgtcgcgc tctccggcga atgtgatctg gggaacatgc tgtgagcgcg gcggcatgct
1540861 agtgacgatg gtgtcgctgc tggtgaacca gggtgtgggt aggcagtcac cgagacccgc
1540921 aaccatggac ggggctggat tcgaggctcc gtgcatgccg tacgactagg ggtagcgccc
1540981 agctgctcaa taccatcggt tggataacaa aggctgaaca tgaatggctt gatctcacaa
1541041 gcgtgcggct cccaccgacc ccggcgcccc tcgagcctgg gggctgtcgc gatcctgatc
1541101 gcggcgacac ttttcgcgac tgtcgttgcg gggtgcggga aaaaaccgac cacggcgagc
1541161 tccccgagtc ccgggtcgcc gtcgccggaa gcccagcaga tcctgcaaga cagttccaag
1541221 gcgacgaagg gcctgcattc cgtccacgtg gtggtgacgg taaacaatct ctcgaccctc
1541281 ccgtttgaga gcgtcgatgc cgacgtgacc aaccaaccgc agggcaatgg ccaggcggtg
1541341 ggcaacgcca aggtcagaat gaagcccaac accccggtgg tggccaccga gttcctggtc
1541401 acgaacaaga ccatgtacac gaagcggggc ggcgactatg tctcggtggg tccggcggag
1541461 aagatctatg acccgggcat catcctggac aaggaccggg ggctgggcgc ggtcgtcggg
1541521 caagtgcaaa acccgacaat ccagggacgt gacgccatcg acggcctggc caccgtcaag
1541581 gtgtccggga ccatcgacgc cgcggtgatc gatccgatcg tgcctcagct aggtaagggt
1541641 gggggcaggc tcccgataac cttgtggatc gtcgacacca acgcctcaac gccggcaccc
1541701 gccgcgaacc tggtgcggat ggtcattgac aaggaccaag gcaacgtcga catcacgctg
1541761 tccaattggg gtgcgccggt caccatcccg aacccggcgg gataacaggc gcgaaccggc
1541821 ccggtccagc cccatcgctg gtcgatggcc tggccggtcc ggtactcgtc cgcgggcgga
1541881 ggccgccttc gaagaaatcc tttgagaatt cgccaaggcc gtcgacccag catggggtca
1541941 gctcgccagc ctgaaccgcc ccggtgagtc cggagactct ctgatctgag acctcagccg
1542001 gcggctggtc tctggcgttg agcgtagtag gcagcctcga gttcgaccgg cgggacgtcg
1542061 ccgcagtact ggtagaggcg gcgatggttg aaccagtcga cccagcgcgc ggtggccaac
1542121 tcgacatcct cgatggaccg ccagggcttg ccgggtttga tcagctcggt cttgtatagg
1542181 ccgttgatcg tctcggctag tgcattgtca taggagcttc cgaccgctcc gaccgacggt
1542241 tggatgcctg cctcggcgag ccgctcgctg aaccggatcg atgtgtactg agatccccta
1542301 tccgtatggt ggataacgtc tttcaggtcg agtacgcctt cttgttggcg ggtccagatg
1542361 gcttgctcga tcgcgtcgag gaccatggag gtggccatcg tggaagcgac ccgccagccc
1542421 aggatcctgc gagcgtaggc gtcggtgaca aaggccacgt aggcgaaccc tgcccaggtc
1542481 gacacatagg tgaggtctgc tacccacagc cggttaggtg ctggtggtcc gaagcggcgc
1542541 tggacgagat cggcgggacg ggctgtggcc ggatcagcga tcgtggtcct gcgggctttg
1542601 ccgcgggtgg tcccggacag gccgagtttg gtcatcagcc gttcgacggt gcatctggcc
1542661 acctcgatgc cctcacggtt cagggttagc cacactttgc gggcaccgta aacaccgtag
1542721 ttggcggcgt ggacgcggct gatgtgctcc ttgagttcgc catcgcgcag ctcgcggcgg
1542781 ctgggctccc ggttgatgtg gtcgtagtag gtcgatgggg cgatcggcac acccagctcg
1542841 gtcagctgtg tgcagatcga ctcgacaccc caccgcaaac catcggggcc ctcgcggtgg
1542901 ccctgatgat cggcgatgaa ccgggtaatt agcgtgctgg ccggtcgagc tcggccgcga
1542961 agaaagccga cgcggtcttt aaaatcgcgt tcgcccttcg caattcggcg ttgtcccgcc
1543021 gcaagcgctt cagctcagcg gattcttcgg tcgtggtccc gggccgtgcg ccggcatcga
1543081 cctgcgcctg gcgcacccac ttacgcaccg tctccgcgca gccaacacca agtagacggg
1543141 cgacctcact gatcgctgcc cactccgaat cgtgctgacc gcggatctct gcgaccatcc
1543201 gcaccgcccg ctcacgcagc tccggcgggt acctcctcga tgaaccacct gacatgaccc
1543261 catcctttcc aagaactgga gtctccggac atgccggggc ggttcagccg cgccggctgg
1543321 caaccgttcc cgctcgagaa agacctggag gaataccagt gacaaacgac ctcccagacg
1543381 tccgagagcg tgacggcggt ccacgtcccg ctcctcctgc tggcgggcca cgcttgtcag
1543441 acgtgtgggt ttacaacggg cgggcgtacg acctgagtga gtggatttcc aagcatcccg
1543501 gcggcgcctt cttcattggg cggaccaaga accgcgacat caccgcaatc gtcaagtcct
1543561 accatcgtga tccggcgatt gtcgagcgaa tcctgcagcg gaggtacgcg ttgggccgcg
1543621 acgcaacccc tagggacatc caccccaagc acaatgcacc ggcatttctg ttcaaagacg
1543681 acttcaacag ctggcgggac accccgaagt atcgattcga cgaccccaac gatctgctgc
1543741 accgggtcaa agcgcggcta gccgagccag cgctggccgc ccggatcaag cgcatggaca
1543801 cactcttcaa cgccatcgtt gcagtactgg ccgtgggtta tttcgcggtt cagggtgtgc
1543861 ggttggtgga accgagctgg atgccgctgt gggccttcgt gattgcgatg gttctgctgc
1543921 gcagttcgtt ggccgggttc ggtcattacg cactgcaccg cgcgcaacga ggcctcaacc
1543981 gggttttcaa caatgccttc gatctcaact atgtggcctt gtccttagtc accgccgacg
1544041 gacacaccct gctgcaccac ccgtataccc agagcgaggt ggacatcaag aagaacgtgt
1544101 tcacgatgat gatgcggcta ccgtggttgt atcgcgttcc cgtacatacg attcacaaat
1544161 ttggccacat gctcagcggc atggcgatcc ggatcgtcga cgtcttcagg atcacgcgca
1544221 aggtaggtgt cgaggaatcc tacggaagct ggcgcgccgc gcttccacac ttccttggat
1544281 cggccggggt gcgcttgctt ctggtgagtg aattggtggt cttcgcgatc gccggcgact
1544341 tctggccctg ggcactgcaa ttcgtagcga cgctgtgggt tagtaccttc ttggtggtgg
1544401 cgagccatga gttcgaggac gacacccagg gcggtgccgt caacggcgag gactggggca
1544461 tagatcaact cgagcacgct aatgacctaa cggtgatcgg gaaccgctac gtcgactgct
1544521 tcctgtcagc cggcctgagc tcccaccgag tccatcacgt gctgccgttt cagcgcagcg
1544581 gcttcgcgaa catcgtcacc gaggacgttt tgcgtgagga agcagcgaag ttcggtgtcg
1544641 agtggcttcc cgcaaagggt ttcatcaccg atcggctgcc gaggctgtgt cggaagtatc
1544701 tgttgacgcc gtcgcgccaa gccaaggagc gtcattgggg tttcgtccgc gagcactgct
1544761 cgccggcggc attgaaagcc agtgccagct acgtggttgc gggtttcgtc ggaatcgggt
1544821 cggtatgaac gtctcagctg agagcggtgc gccgcgccgg gccggccaga ggcatgaggt
1544881 tggccttgcc cagttgccgc cggctccgcc caccacggtg gcggtgattg aagggcttgc
1544941 gacgggcacg ccgcgtcggg tagtcaacca gtccgacgcc gccgatcggg tcgccgagct
1545001 tttcctcgat cccggtcagc gggaacggat tccgcgggtg tatcaaaaat cgcggatcac
1545061 cacgcgccgg atggcggtcg acccgctcga cgccaaattt gatgtcttca ggcgggaacc
1545121 tgcgacgatc cgtgatcgga tgcatctgtt ctacgaacac gcggttccgc tggcggtgga
1545181 cgtgagcaag cgtgccctgg ccggcctgcc ataccgtgcc gccgagatcg ggctgctggt
1545241 gttggccacc agcaccggat tcatcgcgcc gggcgtggac gttgcgatcg tcaaagagct
1545301 cgggctctcc ccgtcgatat cacgtgtcgt ggtcaatttc atgggatgtg ccgccgcgat
1545361 gaatgccctg ggcaccgcca ccaactatgt tcgtgcccac ccggccatga aggcgctggt
1545421 ggtgtgtatc gaattgtgct cggtgaacgc tgtttttgcc gacgacatca acgacgtcgt
1545481 cattcacagc ttgtttggcg acgggtgcgc ggcgttggtg atcggcgcca gccaggttca
1545541 ggagaagctc gagccaggca aggtggtagt ccgcagtagt ttcagtcagc tgctcgacaa
1545601 caccgaagac ggtatcgtgc ttggcgtcaa tcacaacggc atcacctgcg agctgtcgga
1545661 gaatctcccc ggctacatct tcagcggggt cgcaccggtg gtgacagaga tgttatggga
1545721 caatggatta cagatatccg atatcgatct ctgggcgatc catccgggtg gccccaagat
1545781 catcgagcag tcggtgcgct cgctggggat ctccgcggag ctggcggcgc agagctggga
1545841 cgtgctcgcc cgcttcggca acatgctcag cgtatcgctt atctttgtgc tagagacgat
1545901 ggtgcagcag gcggagtcgg ccaaagccat ctcgacgggg gtggcgttcg cgttcgggcc
1545961 gggcgtcact gtcgaaggca tgctgttcga catcatccga cggtgaccgc catgaattca
1546021 gaacacccga tgaccgaccg ggttgtgtat cgatcgttga tggccgacaa cctgcgatgg
1546081 gatgccctgc aattgcgcga cggcgacatc attatctcgg cgccgtccaa gagcggcctg
1546141 acctggacac agcgcctggt gtccctgctg gtgttcgacg ggcccgactt gcccggaccc
1546201 ttgtcgacgg tgtccccgtg gctcgaccag accattcggc ccatcgagga agtggtcgct
1546261 actctcgatg cccagcagca ccgccggttc atcaagaccc acacgccgtt ggacggcctg
1546321 gtgctcgacg accgcgtcag ctacatctgc gtaggacgcg acccgcgcga tgccgcggtg
1546381 tcaatgctgt accaatcggc caacatgaac gaagaccgga tgcggattct gcacgaggcc
1546441 gtagtgccgt ttcacgagcg aatcgccccc ccgtttgcgg aactcggtca tgcgcgcagc
1546501 ccgaccgagg agttccggga ttggatggag gggccgaatc agcctccccc tggcataggt
1546561 ttcacacatc tgaaggggat cggcactctg gccaacatcc tgcaccagct aggcacggta
1546621 tgggtccgcc gtcacctacc caacgtggcc ttgtttcatt acgccgatta ccaggcggac
1546681 ttggcgggcg agctgctccg gccggcaagg gtcctcggta tcgccgcgac ccgcgatcga
1546741 gcccgggacc tggcgcagta cgccacgctg gatgcgatgc gctcccgcgc gtcagaaatc
1546801 gctcctaaca ccaccgacgg catctggcac agtgacgagc gtttcttccg ccggggcggg
1546861 agtggcgact ggcagcagtt cttcaccgaa gccgagcacc tgcgctacta ccaccgcatc
1546921 aaccagctgg cgccacctga tctgctggcc tgggcacacg agggccgccg gggatacgac
1546981 ccggccaact gaggttcagt gccgcattct ctcctgtcag ttgctgcact ttagacgctc
1547041 aatgcgctgc gacaacatta aatgtcagca gtcacaccca gtgtggggga aatttgcata
1547101 tgcgatttag ttgtgtgtag cttgttttgc tgtctgtacg actgcaccga ggggtgagcg
1547161 cgtgtcgcac gaaagtctgt tcgaagaaag cgaagcgccc tacgcggcgc tgtgcgtagt
1547221 tgccaacttc acgacagacg gcgagtgagc aggcgctcat caccagggct acgagcccag
1547281 cacaggggac gcggtgaagc gcatgtccca cgaatccgtg ttccaacaga gtgaagcgct
1547341 ctacacggca tatttttcgc ccaacggcga atgagcgagc gccgatcggt gcgttaggcc
1547401 gggcgggcga ccgcccccgt cgccccttta agtgcgcatg tgcgtagtcc agtcgagggt
1547461 cgggagctgg cccagtgccc caagatgcga tgcggctggc cacattctca tccgcaacgc
1547521 tagttaccac aagtcacacc atacccattt tggcagaaac tattgcacat acagataatt
1547581 gtcggtagct tgtcttgcgg tgcagagaac ggaggaggga atcgcgtgcc ccacgaaatc
1547641 ttgtttgacg cggacgaaaa ggcattctcg gcgttttgca ttatctcgtt tacgaccgac
1547701 agcgagtgaa gctgcggtca tcgggggcgc cactcccaga gaggagagga ggtgaatcgc
1547761 atgtcacagg aaaccttgtt ccaagaaagc caagcgctct acgccgcgta tttctttgcg
1547821 gccgacggtg aatgaccggt cgccgattgg cgcgattccc cgcattcagg gctggcgtag
1547881 cgcaagacga tgacgtgggg tcgaccctga gtcagggctc gacgacaggt gtgttgtcgg
1547941 gcccgaattg gtcgtactgg ccaagccgtg tattagggtc tgcggacccg acgacgatcg
1548001 ctcaccggca cggcacccac cgcatcacta gcccggacga gacctggctg gccctgcagc
1548061 cctttctcgc gccagcaggc attaccgggg tcgccgacgt gacatggctg gattgtcttg
1548121 gcattccaac ggttcaggcg gtgcgcccgg catcgctgac gttgtcggtc agccagggca
1548181 aagccgccag ctatcgggct gcccaggtct cggcggtgat ggagtccttg gagggatggc
1548241 acgccgagaa cgtcactgcc gacttgtggt ctgcgaccgc ccgggatctc gaggcagacc
1548301 tgacttacga ccccgcccaa cttcgccacc ggccgggcag cctctaccac gccggcgtca
1548361 agctcgattg gatggtcgcg acgacgttgc tgaccggtcg ccggacctgg gtaccgtgga
1548421 cggcggtgct ggtgaacgtg gcaacccgcg attgctggga accgccgatg ttcgagatgg
1548481 acaccaccgg actggcctcc ggcaactgct acgacgaggc caccttgcac gccttgtacg
1548541 aggtgatgga gcggcatagc gtggctgcag cggtcgccgg agagaccatg ttcgaggtgc
1548601 caactgacga tgtcgccggc tctgacagcg cccacctggt tgagatgatc cgtgacgccg
1548661 gggacgatgt ggaccttgcc cgcatcgatg tctgggacgg ttactactgt tttgccgccg
1548721 agctcacctc cgcgacgctg gaggtgacct tcggcgggtt cgggttacac cacgacccta
1548781 acgtggcgtt atcgcgggcg atcaccgaag ccgcccagtc gcgcatcacg gcaatcagcg
1548841 gagcccgcga ggacctcccg tcggcgatct accaccggtt cggccgggtg catacatacg
1548901 cgaaggcgcg aaagacgtcg ttgcggctga accgcgcgcg gccgacaccg tggcgggtgc
1548961 ccgatgtcga ctcgctgccc gagttggtgg cgtcggcggc gacggcggtg gccaaccgat
1549021 ccggcaccga gccgctggcg gtcgtgtgcg acttcgccga tgcctgtgtc cccgtggtga
1549081 aggtgctcgc cccgggcctc gtgctgtcga gcgcatcgcc gatgcgcaca cccctacagg
1549141 aggctgaatg acggcctgcg gcaggattgt cgtcaccgct gggcccacga ttagcgccgc
1549201 ggacatccgc tcggtggtgc cggatgccga ggtggcgccg ccgattgcgt ttggccaggc
1549261 gctctcctat gacttgcggt cgggtgacac gctgctgatt gtcgacggat tgttctttca
1549321 gcagccgtcg gttcgacata aggagctttt gacgttgatg gccgacggtg tccgagtcgt
1549381 cggatcgtcg agcatgggcg ccctgcgggc cgctgagctg catccattcg gcatggaggg
1549441 ctatggctgg gtcttcgaaa gctaccgaga tggggtactc gaggccgacg atgaggtcgg
1549501 cgtggtgcac ggcgacgccg acgacggcta cccggtcttc gtcgacgcgc tggtgaacat
1549561 gcgccacacc ctggcgcggg ccgtcgcaac tggtgtggtg tgctccgagc tggccgagcg
1549621 gatcatcgag accgcgcggg ccacaccgtt caccatgcgc acctgggcgc ggctgctgag
1549681 tgaggtcggc gccccggacc agcgcggcct cgccgcacag ttgcggtcac tgcgggtcga
1549741 tgtcaaacac gccgatgcgc tgctggcgtt gcggcagctc ggccagcgcc cccgggtgga
1549801 gccgcttcgt ccgggtccgc cgcccaccgt gtggtcgcgg cggtggcggc agcgatgggc
1549861 accgcccacc tccgtcgccg catcggccga ccacggcgag tcttttgtcg acgtcaccga
1549921 cttggaggtc ttgtcgtttt tgagcgtgag ctcggttgac tactgggcct accggccagc
1549981 actgcaacag gtcgctgcct ggtactggac gttgaaacac cccgaacaat ccggaagcgt
1550041 cggtgagcgt gccgcacgag ccgtcgccga ggtggcatcg gagggctacg ggcgcgccct
1550101 ggaattcatt gcctatcgct acgcacttgc caccggcatc atcgacgaga ccggctttcc
1550161 cgaggcggtc gcagcgcatt ggctcaccac cgaagagcgc cacggcctgg gcaatgaccc
1550221 catctcgatc tcggcgcgag tgatcacccg cacgttgttc gtcgtccggt tattgccggc
1550281 gatcgaccat ttccttgacc tgctgcggaa ggactcccga ctgccccgat ggcgtgccat
1550341 ggcggcccac gcactctgca agcgcgacga tctggcccgg caaaagccgc acctgaacct
1550401 gggccggccc gatccgacgc aattgaagcg cctctttggg gcccgatggg ggacccaggt
1550461 gaaccgcatc gagttggccc ggcgtggact gatgaccgag gacgccttct atgctgccgc
1550521 caccccgttc gccgtcgcgg ccgtcgacga ccaactgccg cgcatcgagg tcggcacctt
1550581 aggacccgcg ccgctgagcg cggacgttcc agaacgccat ttcgacttcg gttccgtcta
1550641 actcgcggcg cacggtggcg ggctccagcg actcgatatc ccagccagcg ccaccgagga
1550701 cgtcgcgcag cgtttgctcg gataccgtcg accgcggcca ttcctcatcg ggcggcatgg
1550761 cgttggagaa gcagctgagt agcagggtgg cgcccggtcg ggtggcccgg tgcaccgagg
1550821 cggcgtagct gcgcttgccg tcgtcgtcta ggcagtggaa catcccgcag tcgatcacgg
1550881 tatcgaacgc gccggtgtag ccggtcagct tggtggcgtc acccactgcg aacttgacat
1550941 cgactccggc gtcgctggct cgccgtttgg cggtggtcag cgcggtggga gagatgtcca
1551001 acccggtcac ctggtagccg ttcctggcga ggtagatcgc gttgtcaccg agcccgcacc
1551061 cgatgtcgag cacgtcgccg tgcacccagc cgccggtgtg ccagccgatg acattgtcct
1551121 tgggcgcttt ggtgtcccac ggcggtgtcg tgatcggcgg gaggccctcg ccggggcttt
1551181 cgccacggta gagcgcgtcg aaatctatac ctggcatgct ggccagctta ggcggcgtgt
1551241 aggtgggtga gggcgacacc gattctggct tccacctggc taacgtctat ctccaacggc
1551301 ccgggcagtg gtggcgcggt gcagtgatag tacatcccgg tgggcgtggt gaattcagct
1551361 gtgtgacggc cggtttcgtc cgtgtcggtg ctgacgcgcc agccgggagc ttccttgacg
1551421 tagttacagc gttcacacga tccgaggccg ttggtcgcgg tggtcgggcc gcctcgatga
1551481 tgcggctggg cgtggtcacg gtggcggatc ggggcatcgc agtagggcat gcgacagcgc
1551541 tgatcgcgca acccgatgaa cgcggccagc cccttcggga accggcgtgc ccgcgattcc
1551601 atcgccacca aggcccccga gcgcggatga cggtagagcc ggcgcagcgt ggcccgtgac
1551661 cgcgtatcgg caaccgcgtc gcgcaccagg ttgcgggcca cggccgccgg gatggggcca
1551721 tacccgtcga ccaccgccgg ggcgcggtcg ccagctaaca gtgtctcgtc ggagagcacc
1551781 aggttgaccg ctaccggttg ggccgcctcg gcgggttgtc cggtgacccg ctcgaccaac
1551841 gtgtcggcca ttacctggcc ccgtgtccga tcgtcgaatg tcgtgtcggc ggcccgcttg
1551901 agcgccgcat agaccgacac gcctcgggcc accggaagca acgccgtcac ccaggtcatg
1551961 gtgtcggggg ccgggcggat cgtcaccgtg cgttcggtct cggccctggc ggcccgctcc
1552021 accaccgcct gggcatcgag ccggtaggca atcgcccggg ccgcggcggc gatccgcgca
1552081 tcacccatcc cgtccaatgc ggacatgtcg gcgcacagct cggcgtcgag tgcgcggcga
1552141 tcctcgacgt ccaggcaggc cgactcccgc acgatcagcg tggcccgcca ctccgatagc
1552201 cgcccgacct cgagcgcggc gagtgtgtgc ggcatctcat acaccaacgc cttcgcgaac
1552261 cccaggtggc gcccgccgcg cgccggcgaa tcccgtcgcg ccagcgctac ttcactggcc
1552321 accccacgcc cgcgccgccg tgccggcacc cccgcatccg cctcattgca gcgacgcaac
1552381 ttgtccagcg ccgccgcagc acgtgcctga ccggcggccg cggccgattt gacccgctcc
1552441 agctcggcga tccgcgcggt caggctcgcc tcatcgtcgc gcgaatccac gcccgcgagg
1552501 ctcactaaat cgaacatgtg ttcgagtata gcaggcctgg gccaccgcgg ccaccgcacc
1552561 gcgggcccgc agcgtgcgag tgctacgctg ccgagcggtc gacatccttt aacgatccgt
1552621 ccagagaggc ggagaaggag gtcaaggttt cccatgggtg ctgcgggtga tgccgcaatc
1552681 ggccgggagt cccgcgagtt gatgtccgcg gccgacgtcg gccgcacgat ttcgcgcatc
1552741 gcgcatcaga ttatcgagaa gaccgcgtta gatgacccag tcggacccga cgcgccgcgg
1552801 gtggtgctgc tgggaatccc gacccgtggc gtgacgctgg cgaatcgcct ggccggcaat
1552861 atcaccgaat acagcggcat ccacgtcggc catggcgcgc tggacatcac cctgtaccgc
1552921 gacgatctga tgatcaagcc gccgcggccc ttggcgtcga cgtcgatccc ggccggtggg
1552981 atcgatgacg cgctggtgat cctggtcgat gacgtgctct actccgggcg ctcggtgcgt
1553041 tccgccctgg acgcgctgcg cgacgtgggc cggccgcggg cggtgcaatt ggcggtgctg
1553101 gtcgacaggg gtcaccggga actgccgctg cgcgccgact atgtgggcaa gaacgttccg
1553161 acctcgcgca gcgagagcgt gcacgtgcgg ctgcgcgagc acgacggccg tgacggcgtg
1553221 gtgatctcgc gatgacccca aggcacctgc tgaccgccgc cgacctcagc cgcgacgacg
1553281 ccaccgccat cctcgacgac gccgaccggt ttgcgcaggc gctggtcggt cgcgacatca
1553341 agaagctgcc gacgctgcgg ggccggaccg tcgtcacgat gttctatgag aactccaccc
1553401 gcacccgggt gtcgttcgag gtagcgggta agtggatgag cgccgacgtg atcaacgtca
1553461 gcgctgccgg atcttcggta ggcaagggtg agtcgctgcg ggataccgcg ctgaccctgc
1553521 gcgcggccgg ggctgacgcg ctgatcatcc gccatcccgc gtccggcgcc gcccatctgc
1553581 tggcgcagtg gaccggcgcc cacaacgatg ggccggcggt gatcaacgcc ggtgacggca
1553641 ctcatgaaca ccccacgcag gcgctgcttg atgcgctgac catccgtcag cgcctcggcg
1553701 gcatcgaagg ccggcgcatc gtgatcgtcg gcgacatcct gcacagccgg gtcgcccgct
1553761 ccaacgtcat gctgctggac accctgggcg ccgaggtggt gctggtggcg ccacccacat
1553821 tgctaccggt cggggtgacc ggctggccgg ccaccgtctc ccacgacttc gatgccgagc
1553881 tgcccgccgc cgacgcggta ttgatgctgc gggtacaggc cgagcggatg aacggcggtt
1553941 ttttcccgtc cgtacgggag tactcggtcc gctacgggct aaccgagcgg cgccaggcga
1554001 tgcttcccgg ccacgccgtg gtgttgcacc cgggaccgat ggtgcgtggc atggagatca
1554061 catcttcggt cgcggactcg tcgcaatcgg ctgtgctgca acaggtttcc aatggagtcc
1554121 aggtgcggat ggcggtgctg ttccatgtgc tggtgggagc gcaggatgcc ggtaaagagg
1554181 gtgcggcgtg agcgtgctga ttcgtggtgt gcggccctac ggcgaggggg agcgggtcga
1554241 cgtactcgtc gatgacggcc agatcgccca gataggaccg gatctggcga tccccgatac
1554301 ggccgatgtc attgacgcca ccggacacgt gctgctgccc gggttcgtcg atctgcacac
1554361 ccatctgcgc gagccgggcc gcgagtatgc cgaggacatc gaaaccggtt cggccgcggc
1554421 cgctttgggc ggctacaccg cggtgttcgc gatggccaac accaaccccg tggccgacag
1554481 cccggtggtc accgaccacg tctggcaccg cggccagcag gtcggcctgg tcgacgtgca
1554541 ccccgtcggc gcggtcaccg tcgggctggc cggagccgag ctgaccgaga tgggcatgat
1554601 gaacgccggc gccgcccagg tgcggatgtt ctccgacgac ggggtctgcg tgcatgaccc
1554661 gctgatcatg cgccgcgccc tggaatatgc caccggtttg ggcgtgctga tcgcccagca
1554721 cgccgaggag ccccggctga cggtcggcgc cgtcgcgcac gagggaccca tggcggcgcg
1554781 gctgggcctg gcgggatggc cgcgggccgc cgaggaatcg atcgtcgccc gcgacgcctt
1554841 gctggcccgt gacgccggcg cccgggtgca catctgtcac gcgtcggccg cgggcaccgt
1554901 cgaaatcctg aaatgggcta aggaccaggg tatttcgatc accgccgagg tcacccccca
1554961 ccacctgttg ctcgacgatg ccagattggc cagctatgac ggcgtgaacc gggtcaaccc
1555021 gccgctgcgc gaagcttccg acgcggtcgc cctgcgacag gcgctggccg acgggatcat
1555081 cgactgtgtg gccacagatc acgccccgca tgccgagcac gagaaatgcg tcgaattcgc
1555141 cgcggcccgg cccggcatgc tcgggttgca gacggcattg tcggtggtgg tgcagacaat
1555201 ggtggcgccc ggcttgttga gttggcgcga tatcgcgcgg gtgatgagtg agaacccggc
1555261 gtgcatcgca cgcttgcccg atcagggccg gccactggag gtgggggagc cggccaacct
1555321 gacggtggtg gaccccgacg ccacctggac ggtcaccggc gccgacctgg ccagccggtc
1555381 ggccaacacg ccgtttgagt cgatgagcct gcccgccacc gtgaccgcga ccctgctgcg
1555441 cgggaaggtg accgcgcgcg acgggaagat ccgggcatga actccggcac gctggcgggg
1555501 tcgctgatct tcgcggcggt gctcgtcatg ctgatcgcgg tgctcgctcg gctgatgatg
1555561 cgcggctggc ggcgccgttc ggagcggcag gcggagctgc tcggcgactt gcccgacgtg
1555621 cccgagcacg tgagctcggc cacggtcacc acccgcggcc tgtacgtggg cgccacgctg
1555681 tcgccggcct ggaacgagcg ggtcaccgtc ggtgatctcg ggtatcgcag caaggcggtg
1555741 ctcacccggt atccgtcggg catcatggtg gaacgcgcac gggctcagcc gatttggatt
1555801 cctacggagt cgatcgccgc cattcgcatg gaacgcggcg tcgccggcaa ggtggtggcc
1555861 ggcatcggga tactcgcgat ccgttggcga ctgccgtccg gcaccgagat cgatgtcggg
1555921 tttcgggcag acaaccgcga cgaataccag gagtggctgg aggaacccgt ttgagcaaag
1555981 ccgtattggt cctcgaagac ggccgggtgt tcaccggcag gccgttcggc gcgaccggac
1556041 aagcgctcgg ggaggccgtg ttttccaccg gcatgtccgg ttatcaggag acgctgaccg
1556101 atcccagcta tcaccgtcag atcgtggtgg ccaccgcgcc gcagatcggc aacaccggct
1556161 ggaacggcga ggactccgaa agccgagggg agcggatctg ggtcgccggt tacgcggtgc
1556221 gcgacccgtc gccgcgcgcg tccaactggc gcgccaccgg cacgttggaa gacgaactca
1556281 tccgccagcg catcgtcggg atcgccggca tcgacacccg ggccgtggtg cgccatctgc
1556341 gcagccgcgg gtcgatgaag gcgggggtgt tctccgacgg ggcgctggcc gagcctgccg
1556401 acttgatcgc gcgggtgcga gcacaacagt cgatgctggg cgccgatctg gccggcgagg
1556461 tcagcaccgc ggagccgtat gtcgtcgaac ccgacgggcc accgggtgtt tcgaggttca
1556521 ccgtggccgc cctagatctt ggtatcaaga ccaacactcc gcgtaacttc gcccggcgcg
1556581 ggattcgctg ccatgtgctg ccggcatcga ccaccttcga gcagatcgcc gaactcaacc
1556641 cgcatggcgt gttcttgtcc aacggccccg gcgacccggc caccgccgat cacgtcgtcg
1556701 cgcttacccg cgaggtgctg ggcgccggaa tcccgttgtt cggcatctgt ttcggcaacc
1556761 agatcctggg ccgcgcgctg ggcctgtcga cctacaagat ggtgtttggg caccgcggca
1556821 tcaacatccc ggtcgtcgac cacgccaccg gtcgggtggc ggtgaccgcg caaaaccatg
1556881 gcttcgccct tcagggggag gcgggccaat ccttcgccac cccgttcggt cccgcggtgg
1556941 tcagccacac ctgcgccaac gacggtgtgg tcgaaggcgt caagctcgtt gacgggcggg
1557001 cgttttcggt gcaataccac ccggaagccg ccgccggccc gcacgatgcc gagtacctgt
1557061 tcgaccagtt cgtggagctg atggcagggg agggccgcta gtgccccgtc gcaccgatct
1557121 gcaccacgtg ctggtcatcg gctccgggcc gatcgtcatc ggccaggcgt gcgagttcga
1557181 ctactccggg actcaggcgt gccgggtgct gcgcgccgag ggcttgcagg tcagcctggt
1557241 gaactctaat ccggccacca tcatgaccga cccggagttc gccgaccaca cctacgtaga
1557301 gcccatcacc ccggcgttcg tggagcgggt tatcgcccaa caggccgagc ggggcaacaa
1557361 gatcgacgcc ctgctggcga ccctgggtgg gcagaccgcg ctgaacaccg cggtcgcgct
1557421 gtacgagagc ggggtgctgg aaaagtacgg cgtggaactc atcggcgccg atttcgacgc
1557481 catccagcgc ggcgaggacc ggcagcggtt caaggacatc gtcgccaagg ccggtggcga
1557541 atccgcccgg agccgagtgt gtttcaccat ggccgaagtg cgtgagacgg tcgccgagct
1557601 cggcctgccg gtggtggtgc ggccgagctt caccatgggc gggctgggtt cggggatagc
1557661 gtactccacc gacgaggtcg accggatggc cggcgccggg ctggcggcct cgcccagcgc
1557721 caacgtgctc atcgaggaat cgatttacgg ctggaaggaa ttcgaactcg agctgatgcg
1557781 cgacggccac gacaacgtgg tggtggtgtg ctcgatcgaa aacgtcgacc cgatgggtgt
1557841 gcacaccggc gactcggtca ccgtcgcgcc ggcgatgacg ttgaccgacc gggaatacca
1557901 gcggatgcgc gacctgggca tcgcgatcct gcgcgaggtg ggtgtggaca ccggcggctg
1557961 caacatccag ttcgcggtca acccgcgcga cggtcggctg atcgtcatcg agatgaaccc
1558021 gcgggtgtcg cgttccagtg cgttggcgtc caaggcgacc ggctttccga tcgccaagat
1558081 cgccgccaaa ctggccatcg gttacaccct cgacgagatc gtcaacgaca tcacagggga
1558141 aacgccggcc tgtttcgaac ccaccctgga ctacgtggtg gtcaaggcgc cgcggttcgc
1558201 gttcgagaag ttccccggtg ccgatcccac cctgaccacc accatgaaat ctgtcggtga
1558261 ggcaatgtcg ttgggccgca acttcgtcga ggcgctcggc aaggtgatgc gctcgctgga
1558321 gacgacccgc gccgggttct ggacggcacc ggatcccgac ggcggcatcg aggaagccct
1558381 gacccggctg cggaccccgg ccgaaggccg gctctacgac atcgagctgg cgttgcggct
1558441 gggtgcgacg gtggaacggg tggccgaggc cagcggtgtc gacccgtggt tcatcgcgca
1558501 gatcaacgag ctggtcaatc tgcgcaacga actcgtcgcg gcacccgtgc tgaacgccga
1558561 gctgctgcgg cgcgccaagc acagcggact atcggatcac cagatcgcgt cgctgagacc
1558621 ggaattggcc ggcgaggccg gcgtgcggtc actgcgcgtg cgcctgggca tccacccggt
1558681 atacaagacg gtggacacct gcgcggcgga gttcgaagcc caaaccccct accactacag
1558741 cagctacgag ctcgaccccg ccgccgaaac agaggtggcc ccgcagaccg aaaggcccaa
1558801 ggtgctgatc ctcggttcgg ggcccaatcg gatcggccag ggtatcgagt tcgactacag
1558861 ctgcgtacac gcggcaacca cgttgagcca ggctggcttt gagaccgtga tggtcaactg
1558921 caacccggag acggtgtcca ccgactacga caccgcggac aggttgtact tcgagccgtt
1558981 gacgttcgag gacgtcttgg aggtctacca cgccgaaatg gaatccggta gcggtggccc
1559041 gggagtggcc ggcgtcatcg tgcagctcgg cggccagacc ccgctcgggc tggcgcaccg
1559101 gctcgccgac gccggggtcc cgatcgtggg caccccaccg gaggccatcg acctggccga
1559161 ggatcgcggc gcgttcggcg acctgctgag cgccgccgga ctgccggcgc caaagtacgg
1559221 caccgcaacc actttcgccc aggcccgccg gatcgccgag gagatcggct atccggtgct
1559281 ggtgcggccg tcgtatgtgc tcggtggtcg cggcatggag atcgtgtatg acgaagaaac
1559341 gttgcagggc tacatcaccc gcgccactca gctatccccc gaacacccgg tgctcgtcga
1559401 ccgcttcctc gaggacgcgg tcgagatcga cgtcgacgcg ctgtgtgatg gcgccgaggt
1559461 ctatatcggc gggatcatgg agcacatcga ggaggccggc atccactccg gtgactcggc
1559521 ctgtgcgctg ccaccggtca cgttgggccg cagcgacatc gcgaaggtgc gtaaggccac
1559581 tgaagccatt gcgcacggca tcggcgtggt ggggctgctc aacgtgcagt acgcgctcaa
1559641 ggatgacgtg ctctacgtcc tggaagccaa cccgagagcg agccgtaccg ttccgtttgt
1559701 atccaaggcc acagcggtgc cactcgccaa ggcatgcgcc cggatcatgt tgggcgccac
1559761 cattgcccag ctgcgcgccg aaggcttgct ggcggtcacc ggggatggcg cccacgcggc
1559821 gcgaaacgcc cccatcgcgg tcaaggaggc cgtgttgccg tttcaccggt tccggcgcgc
1559881 cgacggggcc gccatcgact cgctactcgg cccggagatg aaatcgaccg gcgaggtgat
1559941 gggcatcgac cgcgacttcg gcagcgcgtt cgccaagagc cagaccgccg cctacgggtc
1560001 gctgccggcc cagggcacag tgttcgtgtc ggtggccaac cgggacaagc ggtcgctggt
1560061 gtttccggtc aaacgattgg ccgacctggg ttttcgcgtc cttgccaccg aaggcaccgc
1560121 agagatgttg cgccgcaacg gtattccctg cgacgacgtc cgcaaacatt tcgagccggc
1560181 gcagcccggc cgccccacaa tgtcggcggt ggacgcgatc cgagccggcg aggtcaacat
1560241 ggtgatcaac actccctatg gcaactccgg tccgcgcatc gacggctatg agatccgttc
1560301 ggcggcggtg gccggcaaca tcccgtgcat caccacggtg cagggcgcat ccgccgccgt
1560361 gcaggggata gaggccggga tccgcggcga catcggggtg cgctccctgc aggagctgca
1560421 ccgggtgatc gggggcgtcg agcggtgacc gggttcggtc tccggttggc cgaggcaaag
1560481 gcacgccgcg gcccgttgtg tctgggcatc gatccgcatc ccgagctgct gcggggctgg
1560541 gatctggcga ccacggccga cgggctggcc gcgttctgcg acatctgcgt acgggccttc
1560601 gctgatttcg cggtggtcaa accgcaggtg gcgttttttg agtcatacgg ggctgccgga
1560661 ttcgcggtgc tggagcgcac catcgcggaa ctgcgggccg cagacgtgct ggtgttggcc
1560721 gacgccaagc gcggcgacat tggggcgacc atgtcggcgt atgcgacggc ctgggtgggc
1560781 gactcgccgc tggccgccga cgccgtgacg gcctcgccct atttgggctt cggttcgctg
1560841 cggccgctgc tagaggtcgc ggccgcccac ggccgagggg tgttcgtgct ggcggccacc
1560901 tccaatcccg agggtgcggc ggtgcagaat gccgccgccg acggccgcag cgtggcccag
1560961 ttggtcgtgg accaggtggg ggcggccaac gaggcggcag gacccgggcc cggatccatc
1561021 ggcgtggtcg tcggcgcaac ggcgccacag gcccccgatc tcagcgcctt caccgggccg
1561081 gtgctggtgc ccggcgtggg ggtgcagggc gggcgcccgg aggcgctggg cggtctgggc
1561141 ggggccgcat cgagccagct gttgcccgcg gtggcgcgcg aggtcttgcg ggccggcccc
1561201 ggcgtgcccg aattgcgcgc cgcgggcgaa cggatgcgcg atgccgtcgc ctatctcgct
1561261 gccgtgtagc gggtgccctg ccaccgcgcc gctaaatccc accagcatgg ggtggtgagc
1561321 ccagcgctcg tgtgaccaaa ctcaccgccc tgggccgtcg tcacgctgtg ttaacctctc
1561381 gttcaaatga tattcatatt caatagtggc gctaagtgtc cggttgaatc cccgttgaac
1561441 ccccaacaga tggagtctgt gtcgtgacgt tgcgagtcgt tcccgaaagc ctggcaggcg
1561501 ccagcgctgc catcgaagca gtgaccgctc gcctggccgc cgcgcacgcc gcggcggccc
1561561 cgtttatcgc ggcggtcatc ccgcctgggt ccgactcggt ttcggtgtgc aacgccgttg
1561621 agttcagcgt tcacggtagt cagcatgtgg caatggccgc tcagggggtt gaggagctcg
1561681 gccgctcggg ggtcggggtg gccgaatcgg gtgccagtta tgccgctagg gatgcgctgg
1561741 cggcggcgtc gtatctcagc ggtgggctat gaccgagccg tggatagcct tccctcccga
1561801 ggtgcactcg gcgatgctga actacggtgc gggcgttggg ccgatgttga tctccgccac
1561861 gcagaatggg gagctcagcg cccaatacgc agaagcggca tcagaggtcg aggaattgtt
1561921 gggggtggtg gcctccgagg gatggcaggg gcaagccgcc gaggcgtttg tcgccgcgta
1561981 catgccgttt ctggcgtggc tgatccaagc cagcgccgac tgcgtggaaa tggccgccca
1562041 gcaacacgtc gtcatcgagg cctacactgc cgcggtagag ctgatgccta ctcaggtcga
1562101 actggccgcc aaccaaatca agctcgcggt gttggtagcg accaatttct ttggcatcaa
1562161 caccattccc attgcgatca atgaggccga gtacgtggag atgtgggttc gggccgccac
1562221 cacgatggcg acctattcaa cagtctccag atcggcgctc tccgcgatgc cgcacaccag
1562281 ccccccgccg ctgatcctga aatccgatga actgctcccc gacaccgggg aggactccga
1562341 tgaagacggc cacaaccatg gcggtcacag tcatggcggt cacgccagga tgatcgataa
1562401 cttctttgcc gaaatcctgc gtggcgtcag cgcgggccgc attgtttggg accccgtcaa
1562461 cggcaccctc aacggactcg actacgacga ttacgtctac cccggtcacg cgatctggtg
1562521 gctggctcga ggcctcgagt tttttcagga tggtgaacaa tttggcgaac tgttgttcac
1562581 caatccgact ggggcttttc agttcctcct ctacgtcgtt gtggtggatt tgccgacgca
1562641 catagcccag atcgctacct ggctgggcca gtacccgcag ttgctgtcgg ctgccctcac
1562701 tggcgtcatc gcccacctgg gagcaataac tggtttggcg ggcctatccg gcctgagcgc
1562761 cattccgtct gctgcgatac ccgccgttgt accggagctg acacccgtcg cggccgcgcc
1562821 gcctatgttg gcggtcgccg gggtgggccc tgcagtcgcc gcgccgggca tgctccccgc
1562881 ctcagcaccc gcaccggcgg cagcggccgg cgccaccgca gccggcccga cgccgccggc
1562941 gactggtttc ggaggcttcc cgccctacct ggtcggcggt ggcggcccag gaatagggtt
1563001 cggctcggga cagtcggccc acgccaaggc cgcggcgtcc gattccgctg cagccgagtc
1563061 ggcggcccag gcctcggcgc gtgcgcaggc gcgtgctgca cggcggggcc gctcggcggc
1563121 gaaggcacgt ggccatcgtg acgaattcgt cacgatggac atgggtttcg acgcggcagc
1563181 tccggcccca gagcaccagc cgggtgcccg ggcgtccgac tgtggtgcgg gacctatcgg
1563241 atttgctggc acggtgcgca aagaggcggt cgtgaaagcg gcggggttga ccacgctggc
1563301 cggtgacgac ttcggcggcg gcccaacgat gccgatgatg cccggcacct ggacccatga
1563361 tcagggcgtg ttcgacgagc atcgctgata gctgactggg cagtggctgg caaacagctg
1563421 agagagcact cgagagctat cgtcagggca atgtccgatg atgctgagca cccgcgtttg
1563481 gggcactagc agccacgatg atccttgttg ggttgcaccg cggagatgtc ggcgaaaatt
1563541 ggcagggttg cgttgacgca accatggcgc gacacgcgcg ataggtcgcc caaccgcgag
1563601 tgatccccgg cactgcgagt tgcgacgcca cctgccgcca ccagtcgtcg gccgtcgtcg
1563661 accggttgag caggtccgga aagccgaaat ccattgttag gcaacactat tcatgtccca
1563721 tgccagccat gccggcacgg acacggggct ccgtcgagag gccttcgagg tcgcccggcg
1563781 gaccgctggc cggtggcacg tgctactccc acgctgcacg tttgtcccca aaaccagggg
1563841 gtcgggttag atttcgtcag gaagcctgag tacggtcgtc tgcgctggcc ggcgtacccg
1563901 gccgggacaa acaacgatcg attgatatcg atgagagacg gaggaatcgt ggcccttccc
1563961 cagttgaccg acgagcagcg cgcggccgcg ttggagaagg ctgctgccgc acgtcgagcg
1564021 cgagcagagc tcaaggatcg gctcaagcgt ggcggcacca acctcaccca ggtcctcaag
1564081 gacgcggaga gcgatgaagt cttgggcaaa atgaaggtgt ctgcgctgct tgaggccttg
1564141 ccaaaggtgg gcaaggtcaa ggcgcaggag atcatgaccg agctggaaat tgcgcccacc
1564201 cgccgccttc gtggcctcgg tgaccgtcag cgcaaggccc tgctggaaaa gttcggctcc
1564261 gcctaacccc gccggccgac gatgcgggcc ggaaggcctg tggtgggcgt acccccgcat
1564321 acgggggaga ggcggcctga cagggccagc tcacaattca ggccgaacgc cccgtggggg
1564381 gaacccgccc aggagcgcca gtgagcgtcg gcgagggacc ggacaccaag cccaccgcgc
1564441 gtggccaacc ggcggcagtg ggacgtgtgg tggtgctgtc cggtccttcc gcggtcggca
1564501 aatccacggt ggttcggtgt ctgcgcgagc ggatcccgaa tctgcatttc agtgtctcgg
1564561 ccacgacgcg ggcgccacgc ccgggcgagg tcgacggtgt cgactaccac ttcatcgacc
1564621 ccacccgctt tcagcagctc atcgaccagg gtgagttgct ggaatgggca gaaatccacg
1564681 gcggcctgca ccggtcgggc actttggccc agccggtgcg ggcggccgcg gcgactggtg
1564741 tgccggtgct tatcgaggtt gacctggccg gggccagggc gatcaagaag acgatgcccg
1564801 aggctgtcac cgtgtttctg gcgccaccta gctggcagga tcttcaggcc agactgattg
1564861 gccgcggcac cgaaacagct gacgttatcc aacgccgcct ggacaccgcg cggatcgaat
1564921 tggcagcgca gggcgacttt gacaaggtcg tggtgaacag gcgattagag tctgcgtgtg
1564981 cggaattggt atccttgctg gtgggaacgg caccgggctc cccgtgaccc acgtcgtgac
1565041 tagtcagtat ttagctttcc aagccgctct acgccgccag gagaaatttc acgtgagtat
1565101 ctcgcagtcc gacgcgtcgt tggccgccgt ccccgccgtg gatcagttcg atccgtcgtc
1565161 aggtgcatca ggtggctacg acaccccgct gggcatcacc aatccgccca tcgacgagtt
1565221 gctggaccgc gtctcgagca aatacgccct cgtgatctat gcggcaaagc gtgcccggca
1565281 gatcaacgac tactacaacc agcttggcga gggcatcctc gaatatgtcg gtccgctggt
1565341 tgagccgggg ttgcaagaga agccgttgtc catcgcgttg cgcgagatcc acgccgatct
1565401 gctcgagcac accgagggcg agtagcaggg caggcctgag gtggtggacc ataaacggat
1565461 ccccaagcag gtaatagtcg gtgtctccgg gggcatcgcc gcctacaagg cgtgcacggt
1565521 tgttcgtcaa ctcaccgagg ccagtcatcg cgtccgagtc attcccaccg aatccgccct
1565581 gcgcttcgtc ggtgccgcga ccttcgaggc gctctccggt gagccggtgt gcaccgacgt
1565641 tttcgccgac gttccggcgg tcccgcatgt tcacctcggc cagcaggccg atctggtcgt
1565701 agtggcgccg gccaccgccg acctgctggc ccgcgcggcg gccggtcgag ccgacgatct
1565761 gctgaccgcg acgctgctga cggcgcggtg tccggtgctg ttcgcgccgg cgatgcacac
1565821 cgagatgtgg ttgcatccgg ccaccgtcga caacgtggcc acgctgcgcc gccgcggcgc
1565881 ggtggtgctc gagcccgcga caggacggct taccggcgcc gacagcgggg ccggccgact
1565941 gcccgaggcg gaggagatca ccaccctcgc ccagctgctg ctggagcggc acgacgccct
1566001 gccctacgat ctcgcggggc gaaagctgct ggttaccgcc ggtggcacac gcgagccgat
1566061 cgatccggtg cgctttatcg gcaaccgcag ctccggcaag cagggctatg cggtggcgcg
1566121 ggtggccgcc cagcgcggcg ccgacgttac tttgatcgct gggcataccg cagggctcgt
1566181 cgatcccgcc ggcgtcgagg tggtgcacgt cagctcggcc cagcaactcg ccgacgcggt
1566241 gtccaagcac gctccgaccg ccgacgtatt ggtgatggcg gcggccgtcg ccgacttccg
1566301 gcccgcgcag gttgccaccg ccaaaatcaa gaaaggcgtc gaaggcccac cgaccatcga
1566361 gctgctgcgc aacgacgacg tgctggccgg ggtggtgcgg gcccgagccc atggacaact
1566421 gcccaacatg cgggccattg tgggcttcgc agccgagacc ggcgacgcca atggcgacgt
1566481 gctctttcat gcccgagcta aactgcgacg caaaggctgc gatctgttag tcgtcaatgc
1566541 cgtcggcgaa ggcagggcct ttgaggtaga cagcaacgac ggctggctac tggcgtccga
1566601 tggtaccgag tcggcattgc agcacggctc caagacactg atggcgagcc gtatcgttga
1566661 tgcaatcgtc acgttcctgg caggctgtag cagctaacgg gtccggcggc cggttctgta
1566721 cgggtcctgg acaggtgctg gacgatccct tgctcgattg gacgagctga gattgatgcc
1566781 tgaggatata attcggctaa ctatttatcg gaaggatgac gatagtgagc gaaaagggtc
1566841 ggctgtttac cagtgagtcg gtgacagagg gacatcccga caagatctgt gacgccatca
1566901 gcgactcggt tctggacgcg cttctagcgg cggacccgcg ctcacgtgtc gcggtcgaga
1566961 cgctggtgac caccgggcag gtgcacgtgg tgggtgaggt gaccacctcg gctaaggagg
1567021 cgtttgccga catcaccaac acggtccgcg cacggatcct cgagatcggc tacgactcgt
1567081 cggacaaggg tttcgacggg gcgacctgcg gggtgaacat cggcatcggc gcacagtcac
1567141 ccgacatcgc ccagggggtc gacaccgccc acgaggcccg ggtcgagggc gcggccgatc
1567201 cgctggactc ccagggcgcc ggtgaccagg gcctgatgtt cggctacgcg atcaatgcca
1567261 ccccggaact gatgccactg cccatcgcgc tggcccaccg actgtcgcgg cggctgaccg
1567321 aggtccgcaa gaacggggtg ctgccctacc tgcgtccgga tggcaagacg caggtcacta
1567381 tcgcctacga ggacaacgtt ccggtgcggc tggataccgt ggtcatctcc acccagcacg
1567441 cggccgatat cgacctggag aagacgcttg atcccgacat ccgggaaaag gtgctcaaca
1567501 ccgtgctcga cgacctggcc cacgaaaccc tggacgcgtc gacggtgcgg gtgctggtga
1567561 acccgaccgg caagttcgtg ctcggcgggc cgatgggcga tgccgggctc accggccgca
1567621 agatcatcgt cgacacctac ggcggctggg cccgccacgg cggcggcgcc ttctccggca
1567681 aggatccgtc caaggtggac cggtcggcgg cgtacgcgat gcgctgggtg gccaagaatg
1567741 tcgtcgccgc cgggttggct gaacgggtcg aggtgcaggt ggcctacgcc atcggtaaag
1567801 cggcacccgt cggcctgttc gtcgagacgt tcggtaccga gacggaagac ccggtcaaga
1567861 tcgagaaggc catcggcgag gtattcgacc tgcgccccgg tgccatcatc cgcgacctga
1567921 acctgttgcg cccgatctat gcgccgaccg ccgcctacgg gcacttcggc cgcaccgacg
1567981 tcgaattacc gtgggagcag ctcgacaagg tcgacgacct caagcgcgcc atctagcgtc
1568041 gagggcgcga gcagacgcag aatcgcacgc ggaaaggctt ccgcgtgcga ttctgcgtct
1568101 gctcggcgct agctgctgat gcggtagtcg ccgaggtcga accgccggct gcgccagtag
1568161 gcttcgaccg tggtggtcgg gcgcaacggg acgtcaccgt tcttgtcgaa gtaatagctg
1568221 ttggccagcc gacaactgtc ctgccagaag acctggcggt gccggcggcg catcacctcc
1568281 gcgaaatagc gagcgttggc ttcttcggtc acctcgatgc gggtggcgcc ggtgcggcgg
1568341 gctcgcttca ggcaccggat gatgtggtgt gcctgcgtct cgatgagcgc gaagtacgac
1568401 gacccgacgt agccgtacgg tccgaacacg gtgaagaagt tcgggtagcc gggaacgctg
1568461 acgccctcat aggcctgcag ccgatgctcg tcccagaacc ggctcaagga cgcaccgcca
1568521 gttccggtga cggcataggt cgggatgctg tcggtgtcta gcaccttgaa gccggtcgcc
1568581 agcaccagca catcgatctc gtggctggcg ccgtcggtgg tggccaccgc agtgggtgtg
1568641 atcttgtcga tcggctcggt gaccagccgc acgttgtccc ggttgaacgt cgacagatag
1568701 gtgttgtgga agccgggccg cttgcacccc accgcgtatc ggggggtgag ttgctcgcgc
1568761 accaccggat cgtggacctg ttggcgcagg tagcgccgtc ccgctgactc catgtgcttg
1568821 gccaacggaa acaccgcgaa gtagtgcgcc gcgatgggga acgttgcttc cacgaaggcc
1568881 tggctgagca gccggtggac ggctttgccg ccgggaatcc gcatcgccca gcggacggct
1568941 gtgggcagtg gaacgtcgaa tttggggaaa caccaaatag gggtgcgctg aaaaacggtg
1569001 aggtgggaga caattggcgc catctcggga atgacctgca ccgccgaggc cccggtgccg
1569061 atgatcccga cgcgcttgcc ggtcaggtcc tgggtgtgat cccagcgtgc ggtgtgcatg
1569121 gtgacgcctt caaacgagtc caccccgtcg atgtcgggta gtttgggcac cgtcagaatg
1569181 ccgcatgcgc tgatcaggaa cctggctgtg atttcgccgc ccgggtccgt ttgcacccgc
1569241 cacaggctgt gctcgtcatc gaactcggcg gcaagcacct tggtgttcaa ccggatccgc
1569301 gaccggatgc cgtatttgtc gacgcagtgt tcggcgtagg ccttcagctc gtgtccgggt
1569361 gcataggtgc gcgaccagtg ccggctctgc tcgaaagaga actgatagga gaaggacgga
1569421 atatccacgg cgataccggg ataggtgttc cagtgccagg tcccgccgac accgtcgccg
1569481 gcttcgacca cgaggtagtc gctgaatccc gcccggtcga gcttgattgc ggcgccgatc
1569541 ccggagaacc cggcgccgac gatcagtgcg tggtagtcgg gcatcatcgc ctcctcccga
1569601 tgacgtgtac tccgtgcttg ggtcgcaggg tcagcgtcgc ctcgagttcg acgtgatagc
1569661 caggggcgag gtcaaaggtg aagtgttgac tcatgattgc cgccatcaaa accatctcca
1569721 tcagggcgaa gctctgtccg atgcagatgc gtcggccgcc accgaacggc aggtatgcgc
1569781 agcgaggacg gtccgtgggg caccgcaaaa accggccagg atcgaatcta tccgggtcgg
1569841 gccaccagcg cgggtcgtgg tgaatgtggt gaatcgggat gacgacggtg gtgccgcggc
1569901 gaattcggtg tccgtcgatg atgtcatcat cgacggcctc gcgcgcgatt atccacaccg
1569961 acgagaagta gcgttgcgat tcctgcaggc acgcggtggt ccaggccagc ttgcccaggt
1570021 cgtcggcggt cgggcggcgc atgcccagca cgtcgtccag ctcggtgagc atgtggtcgc
1570081 gggcctgcgg gttcagcgcc atcagatacc agaaccagga catggcgttg gcggtggttt
1570141 cgtggccggc gagcatgaac gtcagagctt catcgcgtac tcgctggcgg ggccagattc
1570201 cgccgtcggc gctcagcaac acgttgagca ggtccgcgga gttagtcggc tcggccagtc
1570261 gccgatcgat caccgagttg atggcgcgat ccagggtcag cgtgatctct tgcatttccc
1570321 gcaacggcgg cggcagatga acacccgagt agatacacca gatcagcgtg tcgtaaaccg
1570381 tccgcggcat cagcccccac agccccagcc gctccagctt ttccgcccgc cgcaggccgc
1570441 gagtcgcaag atcgtgcatg gactgcacca acggcccgaa gtcctggctg aacagggcgt
1570501 tggcgactac ccgcaatgtc gtctcgacca tgctttggtg catgtcgaac tgcgcgccgg
1570561 gcacccgcgc ggcggtgacg tcggcgattg ggtcgatcat cagaccgacg agtccgcgca
1570621 ggtggcgccg ggcgaaggtc gagtttaacg cgccgcgatg tcttgcccat gagtcgccct
1570681 cgtcggtgag caagttaaga ccggcggtgg cccggatcgg tccgtattcg tcggatttga
1570741 catatttcag gcgggcctcg tgcagcacat ggtcgacgta gtcggggtga ctgatcgaga
1570801 caaaacgtct gccagcacaa cgaaatcggg tgatgtcgct gccgcgtagc cggcccagga
1570861 agccgtcgcc ggcgtcgaat ccgatggtga tggcttcccg ggtcatcgtc caggtgctca
1570921 tccgcttggc cggtcccttc aggggccgct gggtggtggc ggtggccatg acttcactgt
1570981 atggatgacg ctgactggcc cgaaatgaga ctatgggaca aagtgttgtg agtttaggac
1571041 agcctcgtgg gacatctacc gcctccggcc gaggtgaggc atccggtgta tgcgacccgg
1571101 gtgctgtgtg aggtggccaa cgagcgcggg gtgccgaccg ctgatgtgct ggcgggcacg
1571161 gcgatcgagc cggccgacct cgacgatccg gacgcggtgg tcggtgcgct tgacgagatc
1571221 accgcggtgc gccggttgct ggcccgattg cccgacgacg ccggtatcgg gatcgacgta
1571281 ggcagccggt tcgcgctcac ccacttcggg ttgttcgggt ttgccgtgat gtcatgtggc
1571341 acccttcgcg aactgcttac catcgcgatg cgctatttcg cgttgaccac catgcacgtc
1571401 gacatcacgt tgtttgaaac cgccgacgat tgcctggtcg aactggatgc cagccacttg
1571461 ccggccgatg tccgtggatt cttcatcgag cgcgatattg ccggaatcat cgcgacgaca
1571521 acgagtttcg cgcttccgtt agccgcgaag tatgcggatc aagtatcggc cgaactggcg
1571581 gttgacgcgg aattgttgcg cccgttgctc gagcttgtgc cggtgcacga cgtcgcattc
1571641 gggcgcgcgc acaaccgggt gcacttcccg cgtgccatgt tcgacgagcc gttgccgcag
1571701 gccgaccgcc atacgttgga aatgtgtatt gcacaatgcg acgtgctgat gcaacgcaac
1571761 gagcgacgcc gtggcatcac ggccttggtg cgcagcaagc tgtttcgcga ttccgggctt
1571821 ttcccaacgt ttaccgacgt tgctggcgaa cttgacatgc atccgcggac gctgcggcgt
1571881 cgacttgccg aggaaggcac ttcgtttcgg gccttgctgg gcgaggcgcg ctccaccgtg
1571941 gccgtcgacc tgctacgcaa cgtcgggctg acggtgcagc aggtgtccac ccggctgggc
1572001 tacaccgaag tctcgacgtt ctcgcatgcg ttcaaacgct ggtatggcgt tgcgcccagc
1572061 gaatattcgc gccgcgggta gaccagccct tttcagggtt tcgcggcccg cgtcggtttg
1572121 gtcgggttag gcggggccgg gctggccggg cggaccgggt tggccgggct ggccgaacag
1572181 ggttcccccg gtcccgccga cgccgccgcc cccgccgttg ccgggggtgc catcgttgcc
1572241 ggccccaccg tttccgccgg cgccgccgcc cccgccgttg ccgattagga cggcggcccc
1572301 accgtttccg ccggtcccgc cgttgccgcc ggtaccgtcc tcgccggcgg tgccgccctt
1572361 tccgccggtc ccgccggtcc cggcgtcgcc gatcaggccg gcggcaccgc ctcgcccgcc
1572421 ggtcccgccg gcgccgccct tgccgaacac gccgaagccg tcgccgccct tgccgccggt
1572481 gccgccggtg ccgccggtgc cgtagagttg tccgccgttg ccaccggccc cgccggcacc
1572541 accaattccg ccattgccgt cgggcccctg ggcgctgtgc ccgccggccc cgccggtgcc
1572601 gccgtggcca atcagaccgg cggacccgcc ggctccgcca gcaccgccaa gaccgttcgg
1572661 actggtgacg gtcccgcctg cccccccggt gccgccgttg ccaatgagtt gcccaccagc
1572721 gccgccggct ccaccggcgc cgccgccctg gccacggata tcaccgccgt tgccgccggc
1572781 accgccgtcg ccgatcagcc aggcattgcc accggccccg ccggcgccgc taattgcgcc
1572841 ttgcccgccg ttgccgccgg caccgccgtt gccgatgagc ccgccggtac cgccggcacc
1572901 gcccgcgccc ccgaagttat tctccccgac tttgcctcca accccagttt gcccgccgcg
1572961 cccgccggcc ccgccgctgc ccgacaggcc gcggccgtcg ccgccggtgc cgccggcccc
1573021 gccgttgcct cctgagctga cgccggttcc gccctgcccg ccgtgtccgc cggcgccgcc
1573081 gtcgccgtgc agccagccac caccgccacc ggcgccgccg ataccccccg tgccgccgtc
1573141 gccggacttg ccgccaccga cccccccttg cccgccggtg ccgccggacc ctccgctgcc
1573201 ccacaatccg gcggcgccgc cggcaccgcc ggcaccgccg acaccaccgg ggtcgccggc
1573261 caccccgacc ccgccattgc cgccggcccc gccgttgccc cacagccatc cgccggcccc
1573321 gccggcacca ccggacgcgc cggtgccacc caggccgccg gccccgccgt ggccgatcag
1573381 cccggccgcc ccgcccgcac cgccggcctg accggtggcg ccggacccgc cgttgccgcc
1573441 gttgccgtac aggatcccgc cggccccgcc ggcctgcccg gtccccggcg ccccgtcggc
1573501 gccgtggccg atcagcgggc gccccagcag cgccatggtc ggcgcgttga tcgcacccag
1573561 cagctgctgc tcgacgttgg cggcctcggc gctggcatac gcgcctgccg tgctcgtgag
1573621 ggtctgcacg atctgctggt gaaacgccgc cgcctgagtt ctcagcgcct gataggtctg
1573681 cgcgtggccg ctaaacagcg ccgccacggc ggcggacacc tcatcggcac cggcggccag
1573741 cacacgcgtc gtggcggccg cggccgcagc attggccgtg ctgatcgccg agccgatgct
1573801 tgccagatcc gtcgccgccg cgcccagcat ttccggctgt gcaaacaaaa acgacatgac
1573861 cgtccccctg aatcctgtgg gtatgagcag acttgtcgtg atcgtgcagc ataagcgcag
1573921 gtgatatagg ccatcattgg taatgttata gaaacgttat aggtgatctt gaccttgtca
1573981 aattgttcga caaggagtgc ggtcttattg caactttgtt tattaatgtc gcgcggcccg
1574041 cggcctggga cctccgtcgg acagcggcga cacgatgcaa ctatgggggc cgcagcgagg
1574101 tgtcgtcggt gtcatgcccg cggtcggtgc cccggcaccg caaatggtgg tttcagctgc
1574161 tcgaacatgg ggaaatgcca cacgttgagg gttgccaatt gcaggtcctg gacgtcggcg
1574221 gtagcagcta tcagatagtc gccaagtcca atccggttgt ggctgcgacg atatcggcgc
1574281 atcatgtcgc cggcgcggcg tgcgattacc tcggttgctg gctgtacccg aaacgatgca
1574341 agcaggcgcc acacctcgcg ccgttcggcg gtccgcattc cgccgatgag ttcggcggtg
1574401 gacaccacgc tgatcgccag cggtccgtcc ttgcgggcgc tgacaagcca atcgcgagca
1574461 gcaacgacac cccgcaaatg cgcgatcagc acatcggagt cgacaaggat catgaggtgg
1574521 cgcgccacac ctgggcaagg tgctgttcac gaccaccgga gcgacgcacc ggcggatcca
1574581 ggtggcgaag cgtgccgaac gaatcgttta tagcctgcag gtccgatgca aggtcgtccc
1574641 cagcggtggt gagggctcgg ttcagcagga ggcggatcag ctcggcgcgc gaaacacctt
1574701 cttgcgcggc caacttgtcg aggcttgccg tctgctcctc gtcgaggtag atgttggtcc
1574761 gcttcataca ccatatcata catcacaatg tgcggcccgg gcggcaccgc ggcgggcggc
1574821 gattcagccg accgggcatg ccgccgacgt tatgcgtgca acgccctctt cagcgccgcc
1574881 aagccgcggc cggtggcttc ggccgcggcg ggcaccacca gggcgaagtt gacgtagccg
1574941 tgcaccatgg tgggctcgtt gcttagctct acggaaaccc ctgcggccgt gagcaattcg
1575001 gcgtagcaag caccgtcgtc gcgcagcgga tcatgctcgg cggtgccgat gaaggcggga
1575061 ggcaggccgg acaggtcagc gtttcccggg gccagtgtcg tgggcagcat cgtgtgatca
1575121 ctgatgtcca gccccggcac ataccaggcc aggaacgcgt cgatgacgtc acggtccagg
1575181 attggcgcat cggcattttc ggtgaaagac ggcagcgaca ggtcggccat ggtcgtcggg
1575241 taccacagca gctggaacac cagcggcggt ccgccgacat cccgggccaa ctgcgccatg
1575301 accgccgaga tgttgccgcc cgcagagtca ccggccacgg cgatccggct cgggtcaccg
1575361 cccagttcgg cggcgttttc gccgacccag cgcaatgccg cccagctgtc gtcgatcccg
1575421 gccgggtagg gatgttccgg ggcaagccgg tagtcgacgg acaccacgat ggcctgcgcg
1575481 ccgacggcgt gggcgcgggc gacggggtcg tgggtgtcca gaccgccgag cgaccagccg
1575541 ccaccgtggt agtagacaac cacgggcagg ttgtcgcgaa cgaccggcgg ccagtagacg
1575601 cggaccggaa tgtcggtgag cccgtcgtag ccaacggtcc gttcctcgat ccgtagctcc
1575661 ggcagcaact ccgggggtgt cttcagctgg cggagccgcg cgcgggcgac ttcgacaccg
1575721 tcggccgcgg tgaaggtcac cggaaaggta tcgagcagca tcttcagcac gggatcgata
1575781 tcaggccggg cgacggtcgg ctctgtcatg ggcctaccgt acgaccgcca ggcctatccg
1575841 tgtagcacaa cccgtagcgc caccagccca cggttggtgg cctcggtggc ggcgggcacc
1575901 acaccggcat agccaacgta gccgtgcacc agcgtctggg cgttgtgcac ctcgacggga
1575961 acaccggcgg cggccagcag ctcgccgtac cgaatcccgt cgtcgcgcaa agggtcgtag
1576021 ccggcgacag cgatgtaggc cggcggcagg tcggccaggt tctccgctcg gccgggcgcc
1576081 attggcgctg gcgggttgtg caagtcgatt tcgcctgcgt accaacggga gaacgcggca
1576141 attgccttga cgtcgaggat cggtgcgtcg gcattctcgg ccaacgacgg cagcgattgg
1576201 tcccacagag tggagggata ccacaacagc tgaaacacaa tgggcgggcc gcccatatcg
1576261 cgggctcgct gcgcgatcac cgcggcgatg gtgccgccgg cggaatctcc ggcgacggcg
1576321 atgcggccga ggtcagcacc gacctggcgg ccatgctcgg cgacccaccg cgttgcggcc
1576381 caagcatctt cgatggcagc ggggtagggg tgctcaggcg ccagccggta gtcgacggac
1576441 acgacaatcg cgtcagcgcc gacggcgtgc tggcggcagg tgccatcgtg cgtgtcgagg
1576501 tcgcccatga cgaatccgcc gccatggaaa tacagcacaa cgggcgcctc ggcttgatcg
1576561 ggacacgttg gcggccaata gatccgggtc ccgatcggcc ccgccggtcc atcgatcgca
1576621 aggtcaacga cccgcagctc ggggtgcacc ggctggcgcg gtagatcgcg caaccgctgg
1576681 cgcacggcct cgatcccatc gtcgatcgat agccgaaacg gaaccgcatc cagtaccttc
1576741 agcaggatgg ggtcgatcgc gggtttctcg tcggcggtgt tgtccaaact gggcataccg
1576801 gtaccgtacg cacctcgctt gctggccggc ggctgggtgg tcgccggctg ggcgggcctc
1576861 gcctacggcg tgtacttgac cgtgatcgca ttgcgcttgc caccgggcag cgagttgacc
1576921 gggcacgcga tgttgcagcc cgcgttcaag gcatcgatgg cggtgctgct ggccgcggcc
1576981 gcggttgccc atcccatcgg ccgcgagcgg cggtggttgg taccggcgct gctgttgtcg
1577041 gccaccggcg actggttgtt ggcgatcccc tggtggacgt gggcgttcgt gttcggcttg
1577101 ggggcattcc tgttggcgca cttgtgcttc attggtgccc tgctgccact ggcgcggcag
1577161 gcggctccat cgcgtggccg ggtcgctgcc gtggtggcga tgtgcgttgc gtccgcgggg
1577221 ctgctggtgt ggttctggcc gcacctgggg aaggacaacc tgaccatccc ggtcacggta
1577281 tacatcgtcg cgctgtcggc gatggtgtgc accgcgttgc tggcacggct gccgacgatt
1577341 tggaccgcgg tcggggcggt gtgtttcgcc gcgtcggact cgatgatcgg cattggccgg
1577401 ttcatcctcg gcaacgaggc gttggcggtg ccgatctggt ggtcctacgc cgcagccgag
1577461 atcttgatta cggccgggtt cttcttcggc cgcgaggttc ctgataacgc cgcagcacct
1577521 acggatagct agcggaccgg ttgtctagca gcggatctcg cggtcaagcc cgcacgcccg
1577581 tcgaagtaga gccgatcgcg cgggtgctgc cgatgttgtc ggtgccgcac ctggaccgcg
1577641 acttcgacta cttggtgccc gccgaacact ccgacgatgc ccagccgggg gtgcgggtac
1577701 gggtgcggtt tcacggtcgg ctggtcgacg ggtttgtcct agagcgccgc agcgacagcg
1577761 atcaccacgg caagctgggc tggctggatc gtgtggtgtc gcccgaaccg gtgctcacca
1577821 cggagatccg ccggttggtc gatgcggtgg cggcgcgcta cgccgggacc cgccaggacg
1577881 tattgcggct cgcagtgccc gcccggcacg cacgggtgga gcgggaaatc accacggccc
1577941 cgggtcggcc ggtggtagcg ccggtcgacc cgtcgggttg ggcggcctac ggtcgcggtc
1578001 ggcaattcct ggccgcgctg gccgactcgc gcgctgcgcg ggccgtttgg caggcgctac
1578061 cgggcgagct gtgggcggac cgattcgccg aggctgccgc gcagaccgta cgtgccgggc
1578121 gcacggtact ggcgatcgtg cccgatcagc gggatctgga caccctgtgg caggccgcga
1578181 cggccctcgt cgatgagcac agtgtggtag cactgtcggc cggcctgggc ccggaggcac
1578241 gctatcggcg ctggctggcc gcgttgcggg gcagcgcgcg gctggtgatt ggcacccgca
1578301 gcgcggtgtt cgcgccgttg agcgagctgg gcctggtcat ggtctgggcc gacgccgacg
1578361 actccctggc tgagccgcgg gcaccctatc cgcacgcccg tgaggtggcg atgctgcggg
1578421 cgcatcaggc gcggtgcgca gcgctgatcg gcggctacgc ccgcacggcc gaggcccacg
1578481 cgctggtgcg tagcggctgg gcgcacgacg tggttgcacc ccggccggag gtgcgtgcac
1578541 gctctcctcg cgtggttgcc ctcgacgaca gcggatacga cgacgcgcga gacccggccg
1578601 cccgcaccgc acggctaccg tccatcgcgc tgcgcgccgc gcgctcagcg ctgcagtccg
1578661 gggcgccggt gctggtgcag gtgccgcggc gcgggtacat cccctcgctg gcctgcgggc
1578721 gctgccgggc gatcgctcgt tgccggtcgt gcacgggtcc gctatcgctg caaggcgccg
1578781 gctcgcccgg tgcggtatgt cgctggtgtg gacgggtgga cccgacactg cgatgcgtgc
1578841 gctgtgggtc ggacgtggtg cgtgccgtgg tggtgggggc ccggcgcact gccgaagagc
1578901 tcggccgggc attcccgggt acggcggtga ttacgtcggc cggcgacacc ctggtgcccc
1578961 agctcgacgc cggcccagcc ctggtggtcg ccactccagg agccgaaccc cgggcgcccg
1579021 gcgggtatgg ggcggcgctg ctgctggata gctgggcgct gctgggccgt caagacttgc
1579081 gcgcggccga ggacgcgctg tggcgctgga tgacggcggc cgccctggtt cggccgcgcg
1579141 gggcgggcgg tgtggtgacc gtggtcgccg aatcgtccat tccgacagtg caatcgctga
1579201 tccggtggga tccggtcggt cacgcggagg ccgaactggc agcccgaacc gaagtcggcc
1579261 tgccgccaag tgtgcacatc gctgctcttg acggccctgc cggcaccgtg acggcattgc
1579321 tggaggcggc tcggctgccc gacccggatc gcctccaagc cgatctgctg ggcccggtgg
1579381 acctgccacc cggcgtccgt cgcccggcgg gcatccccgc cgatgcgccg gtcatcagga
1579441 tgttgctgcg ggtgtgccgc gagcagggcc tggagttggc ggcgagtctg cggcgcggca
1579501 tcggtgtgct cagtgcgcgg caaacccggc aaacccgtag cctggttcgg gtacagattg
1579561 acccgctgca tatcgggtaa acggagtaac cgctagctca acacttccgg gcggtgaaga
1579621 taaggtattc ccactgcatc acgccgtcgc agaggtattc gcgacaaagt tcggtgattt
1579681 cggcgtcgag tgtggcgacg cactcggggc tgtcggcgat ggagcggtag gcgttgatcg
1579741 ccgggccgta gaaattcttg aaatagtcgc gacattcgtc cgggcaaccg aaccggtcca
1579801 ctgtcagcga tcctcgccgg gtacggatgt cggacacatg gtcgcgaaac aggccactca
1579861 cgtaatcctc gcttccccac cacacctcgt gcggcgctcc cgccggcagc gtcggccggt
1579921 acggtctgat ggtggacagc aatttgccgt agaaaccctc gggggtccag ttcagggtgc
1579981 tgatcttgcc gccgcgccgg cagacccggg ccagttcgtc ggcggtgcgc tgatgacgcg
1580041 gggcgaacat caccccgatg gtcgagagca ccgcatcgaa ttcgccggcg ctaaacggga
1580101 gggcttctgc gttggcttcc cgccagccga gctccagtcc ggctgccgca gcacgcgcct
1580161 gggcgcggcg cagcagctcg ggcgtcaggt cgctggcagt gacgtgggca cctgccatgg
1580221 ctgccgggat cgatacgttg cccgagcccg cggccacgtc aagcacgcga tcgccgcggc
1580281 gaataccgct ggtggagact aggattgggc caagcggggc caacagctcc tcggcgatgg
1580341 cggcgtagtc gcccaatgcc cacatttgcc gatgcgtggt cgccggcgcc tggcgctcgc
1580401 tggtgggtgt gtagacagtc atcggaactc ctgcgagacg tcgggtgagg ctggtaccga
1580461 attgtgtcag cagacaacag tatacgttct aaataatcaa tgtcgacgat ggtcagatgc
1580521 tagactttcc tgacttaccc gcacggtgta cgacgaagtt gacgccgggg acggccccgg
1580581 gaaaggggta atgatgccaa cggaatatcc ggcgacagcc gaggaatccg tggacgtgat
1580641 caccgatgca ttgctgacgg cgtcccggtt gctggtagcc atctcggccc attcaatcgc
1580701 tcaggtcgat gaaaacatca ccatcccgca gttccggacc ctggtgattt tgtctaatca
1580761 cggtccgatt aacctggcta cgctggcgac gttgctgggt gtgcaaccgt cggccaccgg
1580821 ccgcatggtc gaccggttgg tcggcgccga actgatcgac cggttaccgc accccacctc
1580881 tcgacgggag ctgctggcgg cgctgaccaa gcgtggacga gatgtcgtcc gtcaggtcac
1580941 cgagcaccgg cgcaccgaga tcgcccgcat cgtggaacag atggcaccgg cggaacgcca
1581001 tgggctggtg cgtgccctga cggcgttcac cgaggcgggc ggtgagcccg acgcacgcta
1581061 cgaaatcgag tagctagcgg ccgagcccgt gtcgggccgt ccgttacgtg ctgggacgac
1581121 ccgacacagg ccggattgcc cgcctcagcg cttttcggcg gtgagcagca ggtactccca
1581181 ttccatgaca ccgtccgaca ggtattgcgc tgcgagttcg acaagctggc ggtcgagctc
1581241 ggcggccagc accgcgttgt caccgatgtg cgcgtaggcc tcgatcgtcg ggccatagtt
1581301 gttcttgaag tagtcgtgga cggcctgggc ggtgtcgaac cgcttcactt ccaacaagcc
1581361 acgggccgtc ttgaggccag tgactccatc gcccagcaga ccagtgacat aggcctcacg
1581421 tccccacaac gccgacggcg gcagatccgc cgacacgctg ggccggtatg gcctaatggt
1581481 tgccagcatc cggccgaaga atccctcgca cgtccagctg atcacaccga tcgtcccgcc
1581541 aggccggcag acgcggacca gctcgtcggc cgcggcctga tgatccggtg cgaacatcac
1581601 gccgatcgct gagatcaccg tgtcgaactc gtcgtcggca aacggcaggg cttgcgcgtt
1581661 ggcttcctgg tattgcaggg tcagcccctg ttgggcggcc ctggcctggg accgctgcag
1581721 cagctcgggc gtcaggtcgg tggaaatgac cgtggcaccc gtcttggctg cgggcagcga
1581781 aatattgcca gagccagcgg cgacgtcgag cacccgaaca cccggcccga tgcccgcggc
1581841 ggcaaccagg atcgggccga gtggcgccat cacctcttct gccatcaggg cgtagtcacc
1581901 cagggcccac atcgcccggt gtgtggccgc aagcgtttgg tcctcgcgag caggtgtgtc
1581961 gatagtcatc aggtctcctg agaagtaagt gatgtggctg cgaacttcga catcgttgtc
1582021 gcgggcacgg cgggagcctg ggcagtagcg tgccttgcgt acccaccgga tacagtatgc
1582081 atcagaaata gtgtattcct ctaactatcg cgcgtgtcgg aattgtggcc cacgccacgt
1582141 cggcggcgct tcttagactg ggcgcgtgcg ccttgtcttt gccggcaccc ccgaacccgc
1582201 gctggcctcg ctgcgcaggc tcatcgaatc gcccagtcac gacgtgatcg ccgtgttgac
1582261 ccgtccggat gccgcctccg gccggcgggg caagccgcag ccgtcaccgg tggcccgtga
1582321 ggcggcagag cgcggcattc cggtgctgcg gccatcgcga ccgaactcgg cagagttcgt
1582381 cgccgaactg tcggatctgg cgccagagtg ctgcgccgtg gttgcctacg gagccctgct
1582441 cggcggtccc ttgctggccg tgccgccgca tggctgggtc aacctgcact tctcgctgct
1582501 gccggcctgg cgtggcgcgg cgccggtgca ggccgccatc gccgcgggag acacgatcac
1582561 cggagccacg acgttccaga ttgagccaag cctggactcg ggaccgatat acggtgtcgt
1582621 caccgaggtg atccagccga ccgacaccgc gggcgatcta cttaagcgac tggcggtatc
1582681 gggggcagcg ctgctatcga ccacgctgga tggcatcgcc gatcagcggc tgacgccgcg
1582741 gccgcaaccg gcagacgggg tcagcgtggc gccgaaaatc accgtagcga atgcccgggt
1582801 gcgatgggac ttgccggcgg cggtcgtgga gcggcggatc cgcgccgtca ctcccaaccc
1582861 cggcgcctgg acgctcatcg gtgacttacg ggtcaaactt ggaccggtgc acctcgacgc
1582921 cgctcaccgg ccatcgaagc ccttgccgcc cggtggaatc cacgtggaac gcacgagcgt
1582981 gtggatcggc accggctcgg aaccggtgcg gctgggccag attcagccgc ccggcaagaa
1583041 actcatgaac gcggccgact gggcgcgggg cgcacggctg gacctggccg cacgggcaac
1583101 atgaccccta gatcgcgtgg gccgcgccgc cggccgctgg acccggcgcg tcgtgcggcc
1583161 ttcgagacgc tgcgggcggt tagtgcgcgc gacgcctacg cgaacctggt gttgcccgcg
1583221 ctgctggccc aacgcggtat cggcggtcgc gacgccgcgt tcgccaccga gctgacatac
1583281 ggcacctgcc gagcccgcgg cctgctcgac gcggtcatcg gtgcggccgc cgagcgttcg
1583341 ccgcaggcga tcgatccggt gctgctagac ctgttgcggc tcggcaccta ccaattgctg
1583401 cgcacgcggg tcgacgcaca cgccgcagtg tcgaccaccg tcgagcaggc cggaatcgaa
1583461 ttcgattcgg cgcgagcagg tttcgtcaac ggtgtactac gaacgatcgc cggccgagac
1583521 gagcggtcct gggttggcga actcgctcct gatgcgcaga acgatccgat cgggcatgcc
1583581 gcgttcgtgc atgcgcatcc ccgatggatc gcccaggcct ttgctgacgc gttgggcgcg
1583641 gcggtcgggg agctcgaggc agttttggcc agcgacgacg aacggccagc ggtgcacctg
1583701 gcggcacgcc ccggggtgct gaccgccggc gaactggccc gcgcggtgcg cggaaccgtc
1583761 ggtcggtatt cgccgtttgc ggtgtatctg ccgcgcggtg acccggggcg actggcgccg
1583821 gtgcgcgacg gccaagcgct ggtccaggac gagggcagcc agttagtcgc ccgagcattg
1583881 accctggcgc cagtcgacgg cgataccgga cggtggctgg acctgtgtgc cggaccgggc
1583941 ggcaagaccg cgctgttggc cgggctgggt ttgcagtgcg cagcccgggt gaccgcggtg
1584001 gaaccctcgc cacaccgcgc ggacctggta gcacagaaca cccgcgggct gccggttgag
1584061 ctcttgcgtg tcgacgggcg gcacaccgac ctcgacccgg gtttcgaccg ggtgctggtg
1584121 gatgcgccct gcaccgggct gggcgcgtta cgccgtcggc cggaggcccg ttggcgtcgt
1584181 cagccggcgg acgtagcggc actggccaag ctacaacgcg agttgttgag cgccgccatc
1584241 gcgctgactc ggcccggcgg tgtcgtgctc tatgccacat gctcgccgca cctggccgag
1584301 actgtgggtg ctgtcgccga cgcgctacgc cgacatccgg ttcacgcgct cgatacccgc
1584361 ccactgttcg agccggtgat cgcggggctg ggggaggggc cccacgttca gctgtggccg
1584421 caccggcacg gtaccgacgc catgttcgcc gcggcgttgc gccgcctgac gtgaggttcg
1584481 ccgcagcggc tcagtaatgt gtcgctcatg gccggtagca cggggggacc gctgatagcg
1584541 ccgtcgatcc tagccgctga tttcgccaga ctcgcggacg aagcggccgc ggtcaacggc
1584601 gccgactggt tgcatgtaga cgtgatggac ggtcacttcg tgccaaacct gaccatcggc
1584661 ctgccggtgg tggagagcct gctggcggtc accgacatcc cgatggattg ccatctaatg
1584721 atcgacaacc cggaccggtg ggctccgccg tatgccgagg cgggcgccta caacgtcacc
1584781 ttccacgcgg aggccaccga caacccggtc ggcgtggccc gcgatatccg ggccgcgggg
1584841 gccaaagccg ggatcagcgt gaagccgggg accccgctgg agccatacct ggacatcctg
1584901 ccccatttcg acaccctgct cgtcatgtcg gtagagcctg gcttcggtgg ccagcggttc
1584961 attcccgagg tgctgagcaa ggtgcgtgcg gtgcgcaaga tggtcgacgc gggcgagctg
1585021 acgatcctgg tcgagatcga cggcggcatc aacgacgaca cgattgagca ggctgccgag
1585081 gccggcgtcg actgctttgt cgccggatcg gcggtgtacg gcgccgatga cccggccgcg
1585141 gcggttgcgg cactacggcg acaggccggt gccgcctcac tccacctgag cctatgaacg
1585201 tggagcaggt caagagcatc gacgaggcta tgggtctcgc catcgagcac tcctaccagg
1585261 tcaaaggcac gacttatcca aaacccccag tgggggccgt cattgtggat cccaacggtc
1585321 ggatcgtcgg cgccggcggc accgagccgg ccggtggcga tcatgccgag gtggtggcgc
1585381 tgcgccgggc cggcggattg gctgccggcg ccatcgtggt ggtcaccatg gaaccctgta
1585441 accactacgg caagactccg ccatgcgtga acgctctgat cgaagccagg gtggggacgg
1585501 tggtctacgc cgtcgccgac ccgaacggga tcgctggggg tggcgcgggc cggctgtcag
1585561 cagcgggcct acaggtgcgg tccggggtgt tggctgaaca ggtggcggcc ggaccgctgc
1585621 gggagtggct ccacaagcaa cgcaccggtc tgccgcatgt cacctggaag tacgccacca
1585681 gcatcgacgg ccgcagcgcc gccgccgacg gctccagcca gtggatctcc agcgaggccg
1585741 cacgcctgga tctgcatcgc cgccgcgcca tcgccgacgc gatcttggtc ggcaccggca
1585801 ccgtcctcgc cgacgacccg gccctgaccg cgcggctggc cgacggctcg ctggcgccgc
1585861 agcagccgct gcgcgtggtg gtgggcaagc gcgacatacc gccggaagca cgggtcctca
1585921 acgacgaggc acgcaccatg atgatccgca cccacgaacc tatggaggtg ctcagggcgt
1585981 tgtcggatcg caccgacgtg ctgctggaag gaggtcccac cctcgccggc gccttcctac
1586041 gagcgggtgc gatcaaccgg atcctggcct acgtcgcacc gatcctgttg ggcggtccgg
1586101 ttaccgcggt cgatgacgtc ggggtgtcca acatcaccaa cgcgttgcgt tggcagttcg
1586161 acagcgtcga aaaggtcgga ccggatctgt tgctgagctt ggtggctcgt tagagcggct
1586221 ccacttgggg cgccagggtc ggttgctcct ggacttccgg ttcatcggca tgttccttgc
1586281 ggccgctgat caacagacct agcaccgcgc cgaacacgca cacgatcgcg gtgatggtga
1586341 atatctcgcc gtacatcagc gcgaacgcct gctggtaccg ggctccaatt gcggccgcgc
1586401 gctcgagcag gctggcgttg ggcgggatgg ccgccgacaa ccccgccagg atctggttga
1586461 accggtacaa cccccaggcg ctcagcgcgg ccacgccgat caacatgccg gtcatccggg
1586521 cgaccaccac cgccgccgaa gcgatgccgt gctgggccga cgggacaacc cgtagggtgg
1586581 ccgacgatag cggcccgatc accagcccca accctaaacc agccaccacc aggtcggtgt
1586641 gcatcgccgg cacggtgaac aatccgagga tgttgtgccg atcggccaac aggtccaccg
1586701 gccagtggga aataagccag taaccgtacg ccgcaataag cagtccggca aaggccaccg
1586761 cacggtcacc ggccctggtg gcgatccacc cgcccgtcac tgccccgatc ggtagggcga
1586821 taaggaacca cagcagcatt ccggccgcct gagcctggtc catctgcagc acgccctggc
1586881 cgaacagctc gacatcaacc agcgtcacca tcagcgccgc gccggcggcg acggaggcac
1586941 ccagcgcgga caggaacggc cggaagtgca caccggccgg gtcgatcagc cgggtgcgag
1587001 cgaaacgttc ccaaccgaag aacgccaccg cggcaacgag agcgccgacc agcaacggag
1587061 ccccgtagtc cggcagtacg tgtttgccgt cgggattggg gttgtacagc ccgatgacgg
1587121 cgaggcccaa cgcgagtgcc agcagcagac caccgaccag gtcgactcgc tcgggctccg
1587181 tgctgcggtc gtgtgagggc aggctgaagt ggatcattac catggcgatc gcggtcaacg
1587241 ggacgttgat ccagaacacg tcacgccagt cgtgcaatag ccaaacgatg aagattccgt
1587301 acaacgggcc cagaacgctg ccgagctcct gcgcggcgcc gataccgccg agcacgccgg
1587361 cgcggttgcg ctgcgaccac aaatcggcgc ccagcgccag cgtgatcggc aatagcgcgc
1587421 cgctggcaac accctggatc gtgcggcccg cgatcagcat gtggaaatcg ccaaaatgcc
1587481 cggccagcgc ggtcactacc gagccgatga tgaacccggc caggctgacc tgcagcatca
1587541 gcttgcgccc gaatcggtcg gaagcccggc ccagcaacgg catggcggcg atgtagccca
1587601 ggaggtacat cgtgacgatc caggtgatcc ggtggagttg gttgatcggt ataccaacgc
1587661 tgttcatgat gtcgcgcatg atggtgacca cgacataggt gtccagggcg cccagcagta
1587721 ctgccaggct gcccgcgcta atcgcgactc gacgtcctgc tcgcatgctg atcagctcac
1587781 cgggggcttc gtgacctgga ccttctcgcc ccatttcgac aaggtcatct ggacggaatt
1587841 gcccgagccg cggtccaact gggcctgtgc cagttgatga tcgccggtct cctgaatcca
1587901 gacggtcgcc ggcaccggct gcgtcgcgtt gaacggcggc gctatctggt tcaccgcctg
1587961 tgccgatacc ttcccgctga tgcggatggt gttctggccg ttgatggtat cccgcccttc
1588021 ggcttttgcg tcggcgaaat tcgccagcac gttggccagg ccggtatccg gattcagcac
1588081 ctgggcgggg tcgtagatgt cggcggcggg accgaaatcg ctccactggt tgggcgtcag
1588141 ggtggcgtac aggatcccgt cgaacaccac gaagtcggca tcgatatcag acccacccag
1588201 cgtgagcttg acgtttcccg tcgcggcggt ggggttggtg gtgagatcgc cgctcagcgt
1588261 cttcagagac agtcccggga tcttgccgtt gaccgtcagc accatgtgcg cgctcttgag
1588321 agccttggtc tgcgcggtgg cctcctcgac cagcggcttc gcgtccggaa gtggtccgcc
1588381 gcttggcttc gagcccgacg agcagccggc aacgacagtg gcggcgatgc taacggcggc
1588441 gaggacggcg atgcgacggc agtggcgtct gggggtccgc ataccctgca tcgtagaggg
1588501 tgtctgtgag ttggccggtc ggcgagtggg gtgcgggtcc gcgggattgc tgcctaacct
1588561 ggtgcgatgt tcaccggaat tgttgaggaa cgcggagaag tgaccgggcg tgaggccctg
1588621 gtcgatgcgg cgcggctgac catccgcggt ccgatggtta ccgccgacgc cggccacggc
1588681 gactcgatcg ctgtcaacgg cgtgtgtctg acggtcgtcg atgtattgcc cgacggccaa
1588741 ttcaccgccg acgtgatggc cgagacactg aaccggtcca acctgggtga gctacggccc
1588801 ggcagccggg tgaacctgga acgcgccgcg gcgctgggca gccggctcgg cgggcacatc
1588861 gtgcagggac atgtggacgc caccggtgaa atcgtggcgc gttgtccctc cgagcactgg
1588921 gaagtggtgc gcatcgagat gccggcttcg gtggctcgct atgtcgtcga aaagggctcg
1588981 atcaccgtcg acgggatttc tctgacggtc tccgggctcg gcgccgaaca gcgggactgg
1589041 tttgaggtct cgctgatccc gacgacccgg gagctgacca cgctggggtc cgctgcggtg
1589101 ggaacccggg tgaacctcga agtcgacgta gtcgcaaagt atgttgagcg gttaatgcgg
1589161 agcgccggct gacatcgctc gccgagggag ggagccccat gtcttgcatt ccggacgaga
1589221 tcgatacgcc cgacgtgctg atcgaccgcg acatccttga ccgcaacatc gggcgaatga
1589281 gttccgccgt cgccgcgaaa gggatcgccc tgcgtcccca cgtgaagacg cacaagctgc
1589341 ctgagatcgc ccatatgcaa ctccgcgcgg gcgcgcggcc tgacggtggc caccatcggg
1589401 gaagtcgagg tattcgtcga ccacggcgcc gacgacgtat tcatcaccta cccattgtgg
1589461 atcggcacac gccaagccga ccggctccgt cagctggctg accgcgctcg catcgctgtc
1589521 ggtgcgggca ccgccgaggg cgcttcgaac accggcgcac ggctcgcaga cgccgctggc
1589581 gcgatcgatg ttctcatcga aatcgacagt ggccatcacc gcagcggcgt ccgtgccgaa
1589641 caagtgttgg aggtcgccca cgccgtcggt gaggctgggc ttcacctggt gggggtgttc
1589701 accttccccg gtcacagtta tgcgccaggt aaacccggcg aagccggcga gcaagagcgg
1589761 cgcgctctca acgacgcggc gaacgcgctg gtcgcggtgg gcttcccgat cagctgccgc
1589821 agcggtgggt ccactcccac cgcattgctc accgccgcgg acggggcctc cgagacgtcc
1589881 cggcgtctat gtgctcggtg acgcccagca actggaactc gggcgctgcg cgccggcgga
1589941 catcgcgctg accgttgccg ccaccgtagt gagccgccag gactgcaggt ccggcttgcg
1590001 ccgaattgtc cttgactgcg gtagcaagat tctcggcagc gatcgtccgg cctgggcgac
1590061 tgggttcggc cgtctgatcg accacgccga tgcgcgcatc gcggcgctgt cggagcatca
1590121 cgccaccgtt gtctggcccg acgacgcccc gctcccgccg gtgggaacac gtctgcgggt
1590181 gattcccaac cacgtgtgcc tgaccaccaa cctcgtagat gatgtcgccg tggtgcgcga
1590241 cgcaaccctg attgatcgct ggaaagtcgc cgcccgcggt aagaaccatt gatcctgtcg
1590301 cacttggtca cggcaatacc gcctggctca atggttcata ctgaatggaa cacgtgggct
1590361 tcgcgtgcgg ccaggcctga cagctaggta gcaaagatga cgaggttgga ctccgtcgag
1590421 cgggcggttg ccgacattgc ggcgggtaag gccgtcatcg tcatcgacga cgaagaccgg
1590481 gagaacgagg gtgacctgat cttcgccgcc gagaaggcaa cgccggagat ggtggccttc
1590541 atggtccgct acacctccgg atacctgtgc gttccgctgg acggtgccat ctgcgaccgg
1590601 ctgggcctgt tgcccatgta cgcggtgaac caggacaagc acgggacggc atacaccgtc
1590661 acagtcgatg cacggaatgg cattggaact ggcatttcgg cgtccgatcg ggctaccacc
1590721 atgcggttgc tggccgatcc gaccagtgtg gccgacgatt tcacccgccc cggtcacgtg
1590781 gtccccttgc gggccaagga tggtggggtt ctgcgccggc ccggccacac cgaggccgcc
1590841 gtggacctgg cccggatggc cgggctgcaa cccgcggggg cgatttgcga gatcgtcagc
1590901 caaaaagatg agggctcgat ggcgcacacc gatgaattgc gggtgttcgc cgatgagcac
1590961 ggtctggcgc tgatcaccat tgctgacttg atcgaatggc ggcgcaagca cgagaagcac
1591021 attgagcggg tcgccgaggc gcggattccg actcgtcatg gggagtttcg cgccatcggc
1591081 tacaccagca tctacgagga cgtggaacat gtcgcgctgg tccgcggcga gatcgccggg
1591141 cccaacgccg acggtgacga cgtgctggtc cgggtgcatt cggagtgctt gaccggcgat
1591201 gtgtttgggt cacgccgctg cgattgcggg cctcagctgg acgccgcgct ggcgatggtc
1591261 gcccgtgagg ggcgcggcgt ggtgctgtac atgcgtggcc acgagggccg cggcatcggc
1591321 ctgatgcaca aactgcaggc ctaccaactg caggacgccg gtgccgacac cgttgacgcc
1591381 aatctcaagc ttggactacc tgccgacgca agggattacg ggatcggcgc acagatcctg
1591441 gtcgatcttg gggtacgttc gatgaggctg ctgaccaaca acccggccaa gcgggtggga
1591501 ctggatggat acggattgca catcatcgag cgcgtgccgc tgccggtgcg ggccaacgcg
1591561 gagaacatcc gttacctgat gaccaagcgt gacaaattgg ggcacgactt ggctgggttg
1591621 gacgattttc acgaatccgt gcatctgccc ggagaattcg gcggtgcctt gtgaagggtg
1591681 gcgccggggt gccggatctg ccgtcgctgg atgcgtctgg tgtgcggctg gcgattgtcg
1591741 ccagcagctg gcacggaaag atctgcgacg cgctgttgga cggcgcccgc aaggtggccg
1591801 ccgggtgtgg cctcgatgac ccgactgtgg ttcgggtgct cggcgcgatc gagattccgg
1591861 tggtggcgca ggaattggcc cgcaatcatg atgccgtcgt cgcacttggc gtcgtgatcc
1591921 gcggtcagac accacatttc gactacgtgt gcgatgcggt aacccaggga ctgacccggg
1591981 tatcgctgga ttcctcgacg ccgatcgcca acggcgtgct gaccaccaac accgaggagc
1592041 aggcgctgga tcgggcgggg ctaccgacgt cggccgagga caagggcgcc caggcgactg
1592101 tggcagccct ggccaccgcg ttgaccctgc gcgagctgcg cgctcactcg tgaccgccgc
1592161 accgaacgac tgggacgtcg tgttgcgtcc tcactggacg ccgttatttg cctacgctgc
1592221 agcgtttctg atcgcggtag cgcacgtcgc ggggggcctg ctgctcaagg tcgggtccag
1592281 tggcgtggtc ttccagaccg ctgatcaggt ggcaatgggt gccctggggc tggtcctcgc
1592341 cggggcggtg ctactgttcg cgcggccgcg gctgcgggtg ggttctgccg ggctttcggt
1592401 gcggaatctg ttgggtgaca ggatcgttgg gtggtctgaa gtgatcggtg tgtcgtttcc
1592461 cggcggtagc cggtgggcgc ggatcgacct ggccgacgac gagtacatcc cggtgatggc
1592521 gatccaagca gtggataagg accgcgccgt ggccgccatg gacacggtgc gctcgttgct
1592581 ggctcgatac cggcctgacc tgtgcgcccg ctgaagcgac ttcccgtacg atcgcgaaat
1592641 ggcatgtctt gggcgccctg gctgtagggg ttgggcgggg gcgagcttgg tccttgtggt
1592701 ggtgttggcc ctggctgctt gcaccgagtc ggtagcgggc cgcgcgatgc gtgctaccga
1592761 ccggtcgtcc gggctgccca catccgccaa gccggcgagg gcgcgcgacc tgctgctgca
1592821 ggacggggat cgcgctccgt tcggccaggt aacccagtct cgcgtcggcg acagctactt
1592881 caccagcgcc gttccacccg agtgctcggc ggcgctgctg ttcaaaggtt ccccgctgcg
1592941 gcctgacggc tcgtcggacc acgccgaggc ggcttataac gtcaccggtc cgctgccgta
1593001 cgcagagtcg gtcgatgtct acacgaatgt cctgaacgtc cacgatgtgg tctggaacgg
1593061 gttccgcgac gtgtcccact gccgtggcga tgccgtcgga gtgagccggg ccggcagatc
1593121 gacgcccatg cgactcaggt acttcgctac gctgtcagac ggtgtcctgg tatggaccat
1593181 gagcaatccg cgctggacgt gtgattacgg attggctgtg gtcccgcacg cggtgctggt
1593241 gttatcggcg tgtggcttca agcccggatt ccccatggcg gaatgggcgt cgaaacggcg
1593301 ggcccaactg gacagccagg tttaacgcca gcccccatgc tcttcgcggg cgggtttgaa
1593361 ccggccaaac ggggtcaaag tcacggcggc ctgggcatac tcaaatgtgt cccacggccc
1593421 accatcggat cccgacgacg gcccactgtg aactgcgccg ctcgtggtgc attacccaga
1593481 ccacgatgag agaatggcgg ggaaatgggt gaattacggt tggtgggcgg tgtgctccgg
1593541 gtccttgtcg tggtcggtgc ggtgttcgat gtggcggtgc taaacgccgg tgcggctagt
1593601 gccgacggcc cggtccagct gaagagccga ttgggcgatg tttgcctgga cgccccgagt
1593661 gggagctggt tcagcccgct ggtgatcaac ccctgcaatg ggaccgactt tcagcgctgg
1593721 aatctcaccg atgaccggca ggtcgagagc gtggccttcc ccggggaatg cgtgaatatc
1593781 ggaaatgctt tgtgggcgcg cctgcagccc tgtgtgaact ggatcagcca gcactggact
1593841 gtccagcccg acggcctggt caagagtgat cttgatgcct gcctcacggt tctcggcggt
1593901 ccggatcctg ggacctgggt gtccacccgc tggtgcgacc ccaatgcacc cgaccaacag
1593961 tgggatagcg tgccgtaacc ggcctgcccg gcgaaccccc gcctttctgg gcgccgtcga
1594021 agcgaccact agcctagata cgtgccagat cccgcaacgt atcgccccgc gcccgggtcc
1594081 atcccggtcg agccgggcgt gtaccgattc cgggaccagc atgggcgagt catctacgtc
1594141 ggcaaggcca agagcctgcg tagccggctg acgtcctatt ttgccgacgt ggccagccta
1594201 gcgccgcgga cccggcagct ggtgaccacc gcggccaagg tcgaatggac ggtcgtgggg
1594261 accgaggttg aggcactgca gctggaatac acctggatca aggagttcga tccgcgattc
1594321 aacgtccgct accgcgacga caagtcctac cctgtgctgg cggtcaccct gggcgaggaa
1594381 tttccccggt tgatggtcta tcgcggtccg cggcgcaagg gtgtgcgcta tttcgggccg
1594441 tactcgcacg cgtgggcaat ccgggaaacg ctggatctgc tcacccgggt gtttccggcg
1594501 cgaacttgct cggcgggggt gtttaagcgg cacaggcaga tcgatcgtcc atgcctgctc
1594561 ggctacatcg acaaatgttc cgcgccgtgt attggcaggg tcgatgcggc ccagcaccgc
1594621 cagatcgtgg cagacttctg cgactttctg tccggcaaga ccgaccggtt cgcccgcgcc
1594681 ttggaacagc aaatgaacgc cgcggccgag caactggact tcgaacgagc ggcgcggctt
1594741 cgcgacgacc tgtccgcact gaagcgtgcc atggaaaagc aggccgtggt gctcggggac
1594801 ggcaccgacg ccgacgtggt ggcattcgcc gacgacgaac tcgaggcggc ggtgcaagtg
1594861 ttccacgtgc gcggcggacg ggtccgcggc cagcgtggct ggattgtcga aaagccagga
1594921 gagccaggag attccggaat ccagttggtc gagcaattcc tgacacagtt ctacggcgac
1594981 caggcggcgt tggacgacgc cgccgacgaa tccgccaacc cggttccccg cgaggtgctg
1595041 gtgccctgtt tgccgtccaa cgccgaggag ctggccagct ggctgtccgg cctgcgcggc
1595101 tcaagggtcg tgctgcgggt gccgcgccgc ggggacaagc gggcactggc cgaaacggtg
1595161 caccgaaacg cagaagatgc actgcaacaa cacaagctga agcgggccag cgatttcaac
1595221 gccagatccg ctgcgctgca gagcattcag gactcgttgg gcctggcaga cgcacccttg
1595281 cggatcgagt gtgtcgacgt cagccatgtg cagggcaccg acgtggtcgg gtcactggtg
1595341 gtgttcgaag acggcctgcc gcgcaagtcg gactaccgcc acttcgggat ccgggaagcc
1595401 gcaggccagg ggcgctccga cgacgtggcc tgtattgccg aggtgacccg gcgccgcttc
1595461 ctgcggcacc tgcgcgatca gagcgatccg gatcttcttt ctccggaaag gaagtcgcgt
1595521 agattcgcct atccgcccaa tctgtacgtc gtcgacggcg gcgcgccgca agtcaacgcg
1595581 gccagtgcgg taatcgacga actcggtgtt accgacgtcg cggtgatcgg cctggccaag
1595641 cggctggaag aggtatgggt gccgtcggag ccggacccga ttatcatgcc gcgcaacagt
1595701 gagggactct atctgctgca gcgagtgcga gacgaggcac accggttcgc tatcacctac
1595761 catcgcagca agcggtcgac gcggatgact gcctcagcgc tggactcggt gccgggattg
1595821 ggggagcatc gccgcaaagc gctggtcacc catttcggat cgatcgctcg cctcaaggag
1595881 gccaccgtcg acgaaatcac cgctgttccc ggtatcggcg tggccacggc cacggccgtc
1595941 cacgacgcac tgcgacctga ctcatcgggg gccgcgcgat gatgaaccat gctaggggcg
1596001 tcgagaatcg ttcggaaggc ggcggtatcg acgtcgtctt ggtaaccggg ctgtccgggg
1596061 ccgggcgcgg cacggcggct aaagtgctgg aagacctggg ctggtatgtg gccgacaatc
1596121 tgccgcccca gctgattacc cgcatggtgg acttcgggct ggccgccgga tcacggatca
1596181 cccagctggc ggtggtaatg gatgtgcgat cgcgcggatt caccggcgac ctcgattcgg
1596241 tccgcaacga gctggccacg cgtgccatca ccccgcgtgt ggtgttcatg gaggcgtccg
1596301 atgacacgtt ggtgcgccgc tacgaacaga atcgccgcag tcatccgctg cagggtgagc
1596361 agactctggc cgagggcatt gccgcagagc gcaggatgct agcaccggtt cgcgccaccg
1596421 ccgacctgat catcgacacg tcgacactgt cggtgggggg cttaagggat agcatcgagc
1596481 gtgccttcgg cggtgatggc ggcgcgacca ccagcgtcac cgttgaatcc ttcgggttca
1596541 agtacggcct gccgatggac gccgacatgg tcatggacgt gcggttcctg ccgaacccgc
1596601 actgggtgga cgagttgcgg ccactgaccg gccaacatcc ggccgtgcgc gactatgtgc
1596661 tgcaccggcc gggcgcggct gagttcctcg agtcctacca tcggttgcta tccctggttg
1596721 tcgacggcta ccgccgagag gggaagcgct atatgacaat cgccatcggc tgtaccggtg
1596781 gtaagcatcg cagcgtcgcg atcgctgaag cactgatggg acttctgcgc tccgatcagc
1596841 aactgtcggt gcgggcgctg caccgggatc tgggtcgcga atgaccgatg gcatcgtcgc
1596901 gctgggcggc ggacacggct tgtatgcgac gctgtctgcg gcccgccggt tgacacccta
1596961 cgttaccgcc gtggtgaccg tcgccgatga cggtggctcg tcgggccggc tgcgcagcga
1597021 gctcgatgtg gtgccgccgg gcgatctgcg aatggccttg gcggcgttgg catccgatag
1597081 cccgcacgga cgcctgtggg caactattct gcagcacaga ttcggcggca gtggtgcgct
1597141 ggccggacat ccgatcggca atctgatgct agcgggcctg tccgaggtgc tggccgatcc
1597201 ggtcgcggct cttgacgaac tcgggcgcat cctcggggtg aaaggcaggg tgctgccgat
1597261 gtgcccggtc gcgcttcaga tcgaggccga tgtctccggt ctggaggccg acccgcgcat
1597321 gttccgcctg atccgtggcc aggtggcgat cgcgaccacg cccggaaagg tgcgccgggt
1597381 gcggctgctg ccgactgacc cgccggcgac ccggcaggct gtcgacgcca tcatggctgc
1597441 cgatctggtg gtcctggggc ccgggtcgtg gttcaccagc gtgatacccc atgtgctggt
1597501 gccgggtctg gccgcagcgc tgcgagcaac gtcggcccgc cgtgccctgg tgctcaacct
1597561 ggtggctgaa ccgggagaga cggccggttt ctcggtggag cgtcatctgc acgtgctagc
1597621 ccaacacgcg cccgggttca ccgttcacga catcatcatc gacgccgaac gagtgccgag
1597681 cgaacgggag cgggagcaac tgcgccgcac ggcgacgatg ctgcaggccg aggtccactt
1597741 cgccgatgtc gccagacctg gtacaccttt acatgacccg ggcaagctgg cggcggtcct
1597801 cgacggggtg tgtgcgcgcg acgtcggcgc gtcggagcct ccggtggcgg ccacacagga
1597861 gataccgatc gacggtggac gaccgagggg tgacgacgcg tggcgatgac gaccgatgtc
1597921 aaagacgagc tgagccgact ggtggtgaag tccgtcagcg cgcggcgcgc ggaggtcacc
1597981 tctctgctgc gattcgccgg cgggttgcac atcgtgggcg gccgcgtggt ggtcgaagcc
1598041 gagctggacc tgggcagtat cgcacggcgg ctgcgtaagg agatcttcga gctctacggc
1598101 tacacggcgg tggtgcatgt gttgtcggcc agcgggattc gcaagagcac ccgctacgtg
1598161 ctgcgggtcg ccaacgacgg cgaggcgttg gcacgccaaa ccggactgct tgacatgcgc
1598221 ggtcgtcccg tgcggggtct gccggcccag gtcgtcggcg gcagcatcga tgacgctgaa
1598281 gctgcgtggc gaggagcatt tttggcgcac gggtcgctga ctgagccggg acgctcctcg
1598341 gcgttggagg tcagttgccc gggcccggag gccgcgctgg cgctggtggg tgcggcacgc
1598401 cggcttgggg tcggcgccaa ggctcgtgag gtgcgcggtg ccgatcgcgt ggtggtgcgc
1598461 gacggtgagg cgatcggcgc actgctgacc cggatggggg cccaagacac ccggctggtc
1598521 tgggaggagc ggcggctgcg tcgtgaggtg cgtgcgacgg ccaaccggct cgccaatttc
1598581 gacgacgcca atctgcgccg ctcggcgcgg gccgcggttg ccgcggccgc ccgggtggag
1598641 cgtgccttgg agatcctcgg cgatacggtg cccgagcact tggcctcggc cggcaaattg
1598701 cgtgtcgagc accggcaggc gtcgctggag gagctgggcc ggcttgccga tcctccgatg
1598761 acgaaagacg ctgtagccgg acgtattcgg cgattgttgt cgatggcgga tcgtaaggcg
1598821 aaggtggacg gcatccccga tacggagtcc gtagtgacgc ccgatctgct ggaagacgcc
1598881 tagcgggctg acttacttcg gtgccacgca caccaattgg ctgcttgccg ggggtattgc
1598941 tggcccttcg atttcctcgg gcggctgcag agagactgac gcggaatcgc agcgccctcc
1599001 ggcaccgagg ctcttgatct cggtgacgac gaatcggctg aactcccggt ttgcagaacg
1599061 tgttccaggc acaagcgcgg tggctacccg cggtgaaggc agcgattcgt cgcacgccga
1599121 cggcgcgtac agcagcacgg atggcggctt gccgggggtc gtcaccgccg gatagcagta
1599181 tccgacccgc accaggtact tcaggcagta atacgcccga tggttctggg tgatcaattc
1599241 gtagtcgatc cgcatgcaac tcggagcgtt ggcatggaat ccgtcattgc ggatccgggc
1599301 ctcccggcta tcgcaagcaa cgacctgcgg acgagacggc gccagcttgg agtcgtaggt
1599361 gaaccggttc aggcacatcc ccaagtccat ggagaacacc aacttcagcg tcgcacgatc
1599421 gtagccccgc ggctcgttgt aacccgaagc ggaagcggtc tggcacgcac tcagcagcag
1599481 cgtgagaatc cccagcaaca ctgggaaaac gagcttctcg gctggcggtc gccggtacga
1599541 cgggaagcta taccgcctcg ccgatgtttg ggccgaagct tgcacacatt gacgataact
1599601 tggtcgcgag accgcagaag ctggcctcga cggcgcgccg gggactacgg tcataccatg
1599661 aagcggcttt cgagcgttga tgctgcgttt tggtccgcgg aaaccgcagg ctggcatatg
1599721 cacgtgggcg cactggcgat ctgcgatccc agcgacgcgc ccgaatacag ctttcagcgg
1599781 ctccgcgagt tgatcatcga acggctgccg gagatcccgc agttgcggtg gcgggtcacc
1599841 ggcgccccgc tcggactgga ccggccgtgg ttcgtcgagg acgaggaact cgacatcgac
1599901 tttcacatcc gccgcatcgg tgttccggct cccggtgggc ggcgcgaact cgaggagctc
1599961 gtcggacggc tgatgtccta caaactggac cgttcccggc cgctgtggga actgtgggtc
1600021 atcgagggcg tcgagggcgg ccgcatcgcc acgctgacca agatgcatca cgccatcgtc
1600081 gacggtgtct ccggtgccgg gctgggcgaa atcctgttgg acatcacacc agaaccacga
1600141 ccaccgcaac aggaaacggt cggcttcgtg ggattccaga ttccgggcct ggaacgccgg
1600201 gcgataggtg cgctgatcaa cgtgggcatc atgacgccct tccgcatcgt caggctgctg
1600261 gagcaaaccg tgcgtcaaca gatcgcggca ttgggtgtgg ccggcaaacc ggcgcgatac
1600321 ttcgaagcgc ccaagacgcg gttcaatgcg ccggtgtcgc cgcaccggcg ggttaccggc
1600381 acacgcgtcg agctggctag ggccaaagcg gtcaaggacg cgttcggcgt caagctcaac
1600441 gacgtcgtct tggcgctggt ggccggggcg gcccggcaat acctacagaa gcgtgacgag
1600501 ctgcccgcca agccgttgat cgcgcagatt ccggtctcca cccgcagcga ggaaacgaag
1600561 gccgacgtcg ggaaccaggt cagctcgatg accgcgtcgc tggcaaccca tatcgaggat
1600621 ccggccaagc gcctggcggc catccacgag agcaccctca gcgccaagga aatggctaag
1600681 gcgccctccg cgcaccagat catggggctg accgagacca cgccaccggg tctgctgcag
1600741 ctggccgccc gggcctatac ggccagcggg ctgtcacaca acctggcccc aatcaacctc
1600801 gtcgtctcca atgtccccgg tccacccttc ccgctatata tggccggcgc gcggctggat
1600861 tcgctggtgc ccctggggcc gccggtgatg gacgtggcgc tgaacatcac ctgcttctcc
1600921 taccaggatt atctggattt cggcctggtg accacacccg aggtggccaa cgacatcgac
1600981 gagatggccg atgccatcga accggcactg gccgagctgg agcgtgccgc ggaatagcaa
1601041 tagctggcct atagctgact acgtggccgg cgggttggtc gcgtacaccc aagacaggaa
1601101 gcgggccacg gcctcggcgg tgtgatgcgc ccgcggggag ccgaagacgt cgaaggcgtg
1601161 ttgggcgtgg ggcaggtccg cgtaggcgac gggcgacttc gacaccgccc gcagttcctc
1601221 gacgaacgca tgggcttcgg ccacggggat cagggagtcg tggcggccgt gcagaacgaa
1601281 gaacggtggg gcgtcggccc gcacatggtg gatcggtgag gcatcgacga agatgtcgcg
1601341 gtgcgtgctg aatttccgtt tcaccacgaa cgtttcgagc aacccgacga attcccgacg
1601401 ccccggcgca tcggtcgtaa accagtcgta acgcccgtat accggaaccg ctgccgccac
1601461 cgaggtgtcg acctgttcga acccgggctg aaatcgcgga tcgttggggg tcaacgccgc
1601521 cagggcgcac agatggccgc cggccgaacc gccgctgatg gcaacgaaat tcggatcccc
1601581 gccgtaggcg gcgatgtttt ccttgaccca cgccagcgcg cgcttcacgt cgacaatgtg
1601641 gtcgggccag gtgtggcgcg gcgacacccg gtagttcagc gacacgcata cccagccgcg
1601701 cgcagccaga tggctcatca acggatacgc ctgcgggcgg cgccacccca gtacccaggc
1601761 gccgccgggc acctgtacca gcaccggtgc cttggcgtcg cgtggcaggt cgcggcggcg
1601821 ccagatgtcg gccaggttgg cccgcccgta tgggccgtag cacacgacgt tcgtcgtctc
1601881 gacgtagcgc cggcgtgcca tggcggtacg cagcgggaga ttgcgacctc tgctacgcat
1601941 cggttccgtg ggcagggtag cgagttcctt agcgtagtcg ggcccgagct gttcggtcag
1602001 gcccgcttcg agcaccggtc caggggtggt ggcgccgcgg tagcggatca ccgcaaggat
1602061 cacccaggcc gctgccgtta aggccagtgc cgcctttcct ttcagcccac cgaagtcgcc
1602121 tcggcggccg cggcgcagtg cgtccagcac ggaggcgcct aggtacactc ctggcacttc
1602181 cgacgtcggc cagcccaacc aaaacgccag aaccgtgctg tagccgctac cggacagtgg
1602241 gcgtaatccg ttggcggcat tgagcaattc caccgctgca cgtgttaacg gtctcgggcg
1602301 tgccatccgc cgaaatcgca ttagctgccg acccgtgatt gcagctcggt gcgcaggatc
1602361 ttgccggtaa tgccgcgtgg cagctcgtcg aggacggcga tgtcgcgcgg taccttgtag
1602421 ttggccaggt tgtctcggac atgctgcttg agggtttccg gggtggccga aacaccgggc
1602481 ttgagcacca cgaaggccgc cagccgctgg ccgtactgct ggtcgtccac gccgatcacc
1602541 gcggcctcgg ccacgtcggg gtgggtggcc agcgtcttct ccacctcgat cgggtagatg
1602601 ttctcaccgc cggagacgat catctcgtcg tcgcgcccga cgacgaacag ccggccgttc
1602661 tcgtcgaggt agccgacgtc gcccgatgac atgaacccgg catggaaatc ctttgcggcg
1602721 ccagatgtat agccatcgaa ttggctgtcg ttgcggacgt agatggtgcc gacctcgccg
1602781 gtgggcacct cggtgaactg ctggtccagg atccggattt cggttccttc ggcgggccga
1602841 cccgcggtgt cgggtgcggt ccgcaggtcc gccggtgtgg cggtggcgat catcccggcc
1602901 tcggtcgcgt tgtagttgtt gtagatcacg tcgccgaatt ggtccatgaa tgcgatcacg
1602961 acatcgggcc gcatccgaga acccgacgcg gcggcgaacc gcaacgaccg gccgtcgtag
1603021 cggtttcgaa tctcggccgg caggtccatg atgcgatcga acatcaccgg caccaccacc
1603081 agacccgtcg cgtggtggcg gtcgatcagg tccagcgtcg cctccgggtc gaacctgcgt
1603141 cgcgtgacga tcgtgcaggc cagcgaggag gccagcacca gctgcgagaa gccccaggca
1603201 tgaaacatcg gcgccacgat cacggtgacc tcctcggccc gccacggcgt gcggtccaag
1603261 atcgccttca gtgtcccgat gccaccgcca gaatgcctgg cgcccttggg tgttccggtg
1603321 gttccggagg tcagcaggat cacttttccg tggctgccgg tgtgctcggg ccgccgtccg
1603381 gcgtgcgcgg ctacaagttt ctcaacggtc aggtcgtggt cttcgtcggt ccacgccacg
1603441 atacgggtgg cctgcggttt ttccgccagc gcgcgatcca ccgtcgcgct gaactcttcg
1603501 tcatagacga cagtgtcgac gccttcgcgg gtaaccacct cggccagtgc cggaccggcg
1603561 aaggaggtgt tgagcaacag gatgtgcgcg ccaatccggt tgaccgccaa cagcgcatcg
1603621 acgaagccgc gatgattgcg gcacatgatg ccgacgaccc tggggggtcc ggctggcagg
1603681 gcctgaagcg ccgcggccag cgcgttgccg cgttcgtcga gctggcgcca ggtcagcgtg
1603741 cccagttcgt cgatcaggcc ggggcggtcc gggcagcgtc gggccgcacc ggcgaacccc
1603801 gccgtaaacc ccatgccttc gcggcgcatg gcggcgacga tccgcaggta gcggtctggt
1603861 cgcagcggag cgatcaaccc tgcccggcgc atggtggcga tcaagccgaa tgcttgtctg
1603921 atacgcatgg cttagcccag aatcgggaag cggcgcttgg cggcgaggtc gttgagggct
1603981 tgctgcatca ccgaccgtac gtgctcgtcg accgcgtcga catcagggtc ctcgccgaac
1604041 tgcttggtga ggttgatcgg gtctaacacc tgcatgacga tcttggcggg cagcggcaga
1604101 ttgggcggga tcgcggcgga gaacccgaac ggaaagccga acgagatcgg caggatgtcg
1604161 ctgcggagca gtcgcttgag ccctagccgc cgggcgagcc aggtgccgcg ggacaggtag
1604221 agctggcttt cctggccacc gatggacacc gccggcacga tgggcacgcc agcttcgacg
1604281 gcagtgctga cgtatccctt gcggccgttg aagtcgatca cgttctccgc gaaagtcggc
1604341 cggtacgcgt catagtcgcc gccgggaaaa acgaccacca cacccccgga ccgcaacgcc
1604401 ttagccgcgt tttctcgggt ggcgcgaatg tagccggtgc gtcggaacaa gtccccggtc
1604461 aggcccatga acaagatgtc gtggctgagc gtgtagaccg gtcggtcgta gccgaacttg
1604521 tcgtagaagt cgacgctgaa gaccggcacg tccatcggga acatgccacc ggagtggttg
1604581 gccacgacca gtgcgccacc cggcgggaag gagtccaggc catgcacctg cgaccggtgg
1604641 taggtcttca agactggacg cagcacactt atcaggcgct gggttaggcc agggtcgaat
1604701 ttgccgatgt cgccgatacc tgcatcgtcc ccgttaccag ggctatcggt ttcgctcaac
1604761 tgttctccct cgaggcctcc gaggcctcat tgccgcgtcg ggtctttaga tggtagcgat
1604821 gcacggtgga taggcacacg cggcaggtct gctagcaagg acgagaggtg gtccagagtg
1604881 gctgaagctg gtggcgggcc catttcggtg atcgcccggc atatgcagtt gattcgcgat
1604941 gacttcatct ccgagttgtt tgacaagatg aaggcggaga ttcgggggct ggattacgac
1605001 gcgcggatgg cggacctgtg gcgggcgagc atcaccgaga atttcgtgac ggccgttcac
1605061 tatttggatc gcgatacgcc gcagtccttg gtggaggctc cagcggccgc gctggcatac
1605121 gcccgcgccg cggcgcagcg tgatattccg ttgtccgggt tggttcgggc gcaccggctc
1605181 gggcatgcgc gtttcttgga ggtggcgatg cagtacgtgt cgctgctgga gcccgctgac
1605241 cgggtgtcga cgatcatcga gctggtgaat cgctccgctc gcctcgttga cctggtggcc
1605301 gaccagttga ttgtcgccta tgagcacgaa cacgatcgct ggctgagtcg ccgcagcggt
1605361 ctgcaacagc aatgggtcag cgagctgctc gccgataccc cggtcgacgt tccgcgggcc
1605421 gagcgcgcgt tgggctatcg gttggacggt gtgcatatcg ccgcggtggt atgggtcgat
1605481 tcggcggtgc ccatcggtga tgtggtggcg caattcgacc aggtgcgctg cttgctggcc
1605541 ggggagctgg gccccgaact gggccccgtg gcgaactcgc tgatggtgcc gaccgatgag
1605601 cgcgaggcac ggctgtggtt ttcgcccgcg cccacgcggg ccttcgcccc gtcgcggatt
1605661 cgcgcggcgt tcgagtcggc gggaatccgg gcgcgtttgg cgtgcggtcg ggtaggggac
1605721 gggctgcgtg ggttccgggc gtcgttgaaa caggccgaac gagtgaaggc gttggccctg
1605781 gccggtggcg cccggcccgg cggccgggtc atgttttatg acgatgtcgc gccagtcgcg
1605841 ttgctggccg acgatctaga ggaactgcgg cggttcgtca ccgatgtgct gggtgacctg
1605901 agtgttgacg acgagcgcaa tagctggcta cgcgagacgt tacgggagtt cttgctgcgt
1605961 aaccgcagct acgtcgccac ggccgacgcg atgatcctgc accgcaacac cattcaatac
1606021 cgggtgatcc aggcgatgga actatgcgga cagaatctcg acgatcccga tgccgcgttt
1606081 cgggtgcaga tggcgctgga ggtctgccgc tggatggcac cggcggtgct ccgcgccaaa
1606141 caatagtgtc tcggtaaccg ccggtccgtt catgccgtgc gcacaatcgt ggtcgtgagc
1606201 ttcggtgtcg gcgcatatgg tctccgacgg attcggcgcc taacgtttgc ccacgtcaaa
1606261 caacccgacc agaaagccag ccgggtccgc cagagggggg cggacccggc gtatacccaa
1606321 ttcgcgtcgc tcggttctag ttgggcgcta tcatccgttg ccacggggtt ggtcggaagg
1606381 tcggtatgtc gttcgttttc gcggtgccag agatggtggc ggcaaccgct tccgatttgg
1606441 ccagcctcgg agcggcgctg agcgaggcca ccgcggcggc ggctatcccc accacacaag
1606501 tactggccgc ggccgccgat gaggtgtcgg cggccatcgc ggagttgttc ggtgcgcacg
1606561 gccaagaatt tcaagcgctc agcgcccagg catcggcgtt tcatgaccgg ttcgtgcggg
1606621 ccctaagcgc cgcagcgggc tggtatgtcg acgccgaggc cgccaacgcc gcgctggtgg
1606681 acaccgcggc caccggcgcg tcggagttgg ggtcaggtgg gcgcacggcg ctgattctgg
1606741 gctccaccgg aaccccgcga ccgcccttcg actacatgca gcaggtctac gaccgctaca
1606801 tcgcacccca ctacttgggc tatgcgtttt ccggcctgta cacgcccgcg cagtttcagc
1606861 cgtggaccgg catccccagc ctgacctacg accaatcggt cgccgaaggc gccggctatc
1606921 ttcacaccgc gatcatgcag caagtcgcgg ccggcaatga cgttgtggtg ttgggtttct
1606981 cgcagggcgc gtcggtcgcc accctggaaa tgcgccatct ggcaagcctg ccggccggcg
1607041 tcgcgccgag tccggatcag ctctcgttcg tattgctggg caaccccaac aacccaaacg
1607101 ggggcatcct cgcccggttt ccgggtctgt acctgcagtc gctcggcctg acgttcaacg
1607161 gtgcgacccc ggacaccgac tacgcgacca ccatttacac gacccaatac gacggctttg
1607221 ccgacttccc gaagtacccg ctcaacatcc tggcggacgt caacgcgctg ctgggtattt
1607281 actattcgca cagcttgtat tacgggctca cgcccgagca ggtcgcttcg ggtatcgtcc
1607341 tgccggtgtc ttcgccggac accaacacca cctatattct gcttcccaac gaggatctgc
1607401 cgctgctgca gccgctgcgc ggtattgtgc ccgagccgct gctggatctc atcgagccag
1607461 acctgcgcgc gatcatcgaa ttgggttatg accgaaccgg atacgccgat gttccgaccc
1607521 cggccgcact gttcccggtg cacatcgacc cgatcgcagt cccgccccag ataggcgctg
1607581 cgatcggtgg tccgctcacc gccctggatg gcttgctcga caccgtgatc aacgatcaac
1607641 tcaatcccgt cgtaacgtcg ggcatctatc aggccggtgc tgagctgtcg gtggccgcgg
1607701 ccggctacgg tgctcccgca ggcgtcacca atgccatttt tattgggcag caagtgttgc
1607761 cgattttggt ggaaggcccc ggtgccttgg tgacggccga cacccattac ctggtcgatg
1607821 cgattcagga tttggccgcc ggtgacctca gcgggttcaa ccaaaacctg caactcatcc
1607881 cggctaccaa catagccctg ctggtcttcg cggccggaat tcccgctgtg gcggccgtcg
1607941 ccatccttac cggtcaggat tttccggtat aggcccccgg cccccgctgt accgagctcg
1608001 gccagtgaag aacaacccca ggcgttgcca gtccgaatag attgtattcg tcagccggcg
1608061 caggacagga agcgaggccg ccatgggatt tctgaagccc gatcttcccg acgtcgatca
1608121 cgacacctgg ttgacccagc cacgccggac acgattgcag gtcgtgacac gggactgggt
1608181 agaacacggt ttcggaacgc cgtatgcggt gtacctgctc tatctgacca agattgcggt
1608241 gtacgtcgcc gccggcgccg cgatcatctc gctgaacccc ggactgggcg ggctgagccg
1608301 cataggcgac tggtggacac agccgatcgt gtaccagaag gtcatcgtct tcacgttgct
1608361 gttcgaggtt ttgggttttg gctgcggatc cggcccgctg accgggcggt tttggccacc
1608421 catcgggggc ttcctttatt ggttgcggcc caacacaatt cggctgcctg cttggccgga
1608481 taaggtcccg ttcacccaag gcgacacccg caccgtcgtc gacgtcgcct tgtatgccat
1608541 cgtgttgatc ggcggggtgt gggcgctgtt gtcacccggc tcgccaggtc cggggggaac
1608601 gccggtcacc gccgccggcg acgtcggcct gatcaacccg gtgctggtag tgccgacgat
1608661 cgtcgccctg ggcgtcttgg ggctgcgtga caagacgatc tttcttgccg cccgcggcga
1608721 acactactgg ctgaagctat tcgtgttctt ttttcccttc accgaccaga tcgcggcgtt
1608781 caagatcatc atgctgtgct tgtggtgggg ggcggcgact tccaaactca accaccattt
1608841 cccctacgtc gtcgcggtga tgaccagcaa caacgccctg ttgcgcagca gagtgttcaa
1608901 cccgatcaag cacctgcttt accgcgacca cgccaacgat ctgcggccct cctggctacc
1608961 gaaactcatg gcccacgggg gtggcaccac ggcggaattc ctggtgcccg ggattctggt
1609021 gctcgtcgcc gacggtcacc catggcggtg gttcctcatc gggttcatgg tgctctttca
1609081 cctcaacatc ctgtccaacc tcccgatggg ggtcccgttg gagtggaacg tgttcttcat
1609141 cttctcgctg tgctatctat tcggccacta cggcgcgatc actgccaccg accttcggtc
1609201 gccgttgctg ctggcgatcg tgatcgcggt ggttgccgtg gtgatcatgg gaaacctgtt
1609261 gcccgaaaag atttcgtttc tgcccgccat gcgctactac gccggcaact gggccaccag
1609321 catctggtgc ttccgaggtg atgcggaagc caccatggaa accagcgtcg tgaaaagctc
1609381 tgcgctggtg gtcaatcagc tggccaagct ctacgacggg gccacggccg aaatcatgac
1609441 cgacaaggtc gccgcattcc gggccatgca cacccacggc agggcgctca acggcctgct
1609501 gccccgcgct ctcgatgacg aagctcacta ccgcatccgc gagggcgaaa tcgtggccgg
1609561 gccactggtc gggtggaatt tcggcgaggg ccatctgcac aacgagcagc tggtggccgc
1609621 cgtgcagcgg cggtgcaact tcgccgacgg cgatctgcgg gtgatcattc tcgaaggtca
1609681 gcccatccac gttcagaagc agtggtatcg cattgtcgac gccaagaccg gtttgttcga
1609741 ggccggttac gtcacggtcg aggacatgtt gagccgccag ccatggcccg agcccggtga
1609801 cgagttcccg gttcacgtca cgacgcaacg cggcacgcca tcaaagccat gacgaccgcg
1609861 gtcgtcgtcg gagccgggcc caacggcctg gccgcggcga tccacctggc ccgtcacggt
1609921 gtcgacgtgc aggtgctgga ggcgcgcgac accatcggcg ggggagcacg ctccggtgag
1609981 ctgacggtgc ccggggtcat ccacgaccac tgttcggcgt ttcatccgct gggcgtcggg
1610041 tcgccattct gggcggcgat cgacctgcaa cgctacgggc tgacgtggaa gtggccggac
1610101 gtcgactgcg cacacccact cgatgacggc accgcgggcg tgctatatcg gtcgatcgaa
1610161 gccaccgccg ccggcctggg tcccgacggc aagcggtggc agcgcgccgt gggtgacctc
1610221 gccgccggat tcgatgagct ggccgaggat ctgctgcgcc cggtgctcaa catgccgcgt
1610281 cacccgatcc gcctggcccg ctttggtccg cgcgcggcgc tgccggccac cgccatggcg
1610341 cgtcggtttc acaccgagcg ggcgcgcgcg ttgttcggcg gcgccgcggc gcacgtctac
1610401 accaggttgg atcggccgct gaccgcgtcg ctggggttga tgatcctggc cagcggccat
1610461 cgccacggtt ggccggtcgc ccggggcgga tccgggtcga tcacgaaggc gctggccgcg
1610521 gccctggacg cgtacggcgg caccgtcgcc accggggtga ccgtcaccag ccgccgcgac
1610581 atccccgacg ccgacatcgt gatgctcgac ctcagcccgg ccgcggtgct cgggatctac
1610641 ggcgatgtga tgcccacccg catcaaccgg tcctatcggc gctaccgcgc cggatcgtcg
1610701 gccttcaagg tcgacttcgc catcgagggc gacgttgggt ggaccaaccc cgattgccgg
1610761 cgcgcgggca ccgtccacct gggcgggacc ttcgcggaaa tcgcagacac cgaacgtcaa
1610821 cgcgcccaag gcacgatggt gcagcgacca ttcgtgctcg tcgggcagca gtacctcgcc
1610881 gacccgtccc gctcggtcgg caacatcaac cccatctggg cctacgcgca cgtgccgttc
1610941 ggctacaccg gcgacgccac cgccgccgtc atcgaccaga tcgagcggtt cgcccccgga
1611001 ttccgcgacc gcatcgtggc aaccgtcagc acctccacca ccgaactgca aacgtacaac
1611061 cgcaacttca tcggcggaga cattatcggc ggcgccaacg accggctgca ggtcatcttc
1611121 cgcccgcgcg tggccgtcga tccgtatgcg atcggtgtgc cgggtgtcta tctgtgttca
1611181 cagtccgcgc cacccggtgc cgggatccac ggattgtgtg gctaccacgc cgccgaatcg
1611241 gcgctgaggt ggctgcgcaa gcgacgttga cgcaggtcat cgtcgagatc gacgttagcg
1611301 cgacgtccac tcgtgccgta gccaaaacgt gacggaggtt tgatcgaatt gctaaggcgc
1611361 gcctgcactt ccactcttca atgcacctct accatcactg gtgcaactgt gtcgttgaca
1611421 gggaattgga gccatgcggg cggtttttgg gtgtgctatt gccgtcgtcg ggatcgctgg
1611481 gagcgtggtt gcggggccgg ccgacataca cctggtggcg gcgaagcagt cttacgggtt
1611541 cgccgtcgcg tcggtgctac caacgcgcgg ccaggtggtg ggcgtggcgc accccgtggt
1611601 ggtgacgttc agtgcgccga taactaaccc agccaatcgg cacgcggccg agcgcgccgt
1611661 tgaagtcaaa tcgacgcccg cgatgaccgg caagttcgaa tggctcgaca acgacgttgt
1611721 gcagtgggtt cccgaccgct tctggccggc gcacagcacg gtggagcttt cggtgggcag
1611781 cctgtcgagc gatttcaaga cgggtcccgc cgtcgtcggg gttgccagca tctcccagca
1611841 cacgttcacc gtgagtatcg acggagtcga ggagggaccg ccgcctccgc tgccggcgcc
1611901 gcaccaccga gtgcacttcg gcgaagatgg ggtgatgccg gcatcgatgg gtagaccgga
1611961 atacccgacg ccggtcggct cctacactgt cttgtccaag gaacgctcgg tgattatgga
1612021 ttcgagcagc gtcggcatcc ccgtcgacga tcccgatggt taccggcttt cggtggatta
1612081 tgccgtccgc atcaccagcc gcggcctcta cgtgcattca gccccgtggg cccttccagc
1612141 actgggactt gaaaatgtca gccacggctg cataagcctg agccgcgagg acgcagagtg
1612201 gtattacaac gcggtcgaca ttggcgaccc ggtcattgtg caggaatagc agctgatgcg
1612261 ggcgtcgccc gcagagcgcg tcgacggcgc gtacgcgggt gcggggcctc acacccagtc
1612321 cgtcctggaa gaggaccagc gtcagcgcgc acctgcgggc gcagaggccg aaggaccggg
1612381 cagaaccggc tgaccaggca ccggtccgcc agctggcgcc ggatcggtca gcgcatcctt
1612441 gaccccggac atgccaatga tgggagcact gaccacacca tccccgggag caccagccag
1612501 gaccggccca agcgcaatca gcggagttcc gaccggtatc accggagccg gaacggcggg
1612561 taccggtacc ggtgcgcccg gtatcggtac cggtccgccg gggattggta ccggtgcgcc
1612621 cggtatcggt accggtgcgc cagggattgg taccggtgcg ccgatgggca ccggtgcagc
1612681 tgccggcact ggcccaggcg cgacgaacgg aacaccagcc atgtcagtaa gtgcggcact
1612741 gcacgctccc gcggctgccg gtccaccggc agccaccggg tcgccggcgg ctaccggcgc
1612801 gtcgcccgcc atgccctgga tgcacgcgta gccacccgtc atcagcgggt cagccgccgc
1612861 gtccgggctt aacgctatag cagctgcaaa caacccagcg ccggcaatta ctttgatgtt
1612921 gaaccgattg acgatcgcca tcagcgtcaa ctctcctcta ttcgcgcgca gatatttccg
1612981 caatcaattt ggttcagcag aaccgcatag ccgtatcgag ttccttttcg accatcggct
1613041 caattgtcag catcctatgg ggaacatgag ccccgccgca ccgggccgtt tccaaatggt
1613101 gacgtcacaa cggtgtcaca agccagcgca atgtccgcgg tagggacgcg gcggctggga
1613161 tcggtggggt gagcgcccgg cttctcaaag cgaggggagc cccgggactc ttaccggccg
1613221 aaggcggcgg gtgtcactga tctaggctga cggccagtgg ttgtttagcc aacaaggatg
1613281 acaacaaata agccgaggag agacaagtga cggtccgagt aggcatcaac gggtttggtc
1613341 gaatcggacg caacttctac cgggccttac tggcccaaca ggagcagggc accgccgacg
1613401 tggaggtggt cgccgccaac gacatcaccg acaacagcac gctggcgcat ctgctcaaat
1613461 tcgactcgat tctgggccgg ctgccttgcg atgtcggcct cgaaggcgac gacaccatcg
1613521 tcgtcggccg cgcgaaaatc aaggcgctcg cggtccggga ggggccggcg gcattgccat
1613581 ggggagacct cggcgtcgac gtcgtcgtcg aatccaccgg cctgttcacc aatgcggcca
1613641 aagccaaagg ccacctggac gccggcgcca agaaggtgat catctctgcg cccgccaccg
1613701 acgaggacat caccatcgtc ctgggagtta acgacgacaa gtatgacggc agccagaaca
1613761 tcatctccaa tgcgtcgtgc accacgaact gccttgcgcc gctggccaaa gtgctcgacg
1613821 atgagttcgg catcgtcaag ggcctgatga ccaccatcca cgcctacact caggatcaga
1613881 acctgcagga cgggccgcac aaggacctgc gtcgcgcccg cgccgccgcg ctgaacatcg
1613941 tgccgacctc caccggcgcg gccaaggcca tcggcctggt gatgccgcag ctaaagggca
1614001 agctcgacgg ttatgcgctg cgggtgccga tccccaccgg ctcggtcacc gaccttacgg
1614061 tcgacttatc cacacgggcc agtgtcgatg agatcaacgc ggcgttcaaa gccgcggccg
1614121 aaggcaggct caagggcatt ctgaagtact acgacgcgcc gatcgtctcg agcgacatcg
1614181 tcaccgaccc gcacagttcg attttcgact ctgggttgac caaagtcatc gacgaccagg
1614241 ccaaggtggt gtcgtggtac gacaacgagt ggggctactc caaccgcctg gttgatctgg
1614301 tcacgctggt cggcaagtcg ctctagccat gagcgttgca aacctcaagg atctactcgc
1614361 cgaaggtgtt tcggggcgtg gagtgctggt gcgctccgat ctcaacgttc cgctcgacga
1614421 ggacggcacc attaccgatg cgggccgcat catcgcgtcg gcgccgacgt tgaaggcgtt
1614481 gctcgacgcc gacgccaagg tggtggttgc cgcgcacttg ggacgtccca aggacgggcc
1614541 ggacccgaca ctgtcgctgg cgccggtcgc cgtggcgctg ggtgagcaac tcggccggca
1614601 cgtccagctg gctggagacg ttgtcggcgc cgatgcgctg gcccgcgccg aggggctcac
1614661 cggcggcgac atcctgctgc tggagaacat ccgcttcgac aaacgcgaaa ccagcaagaa
1614721 cgatgacgac cggcgggcac tggccaagca gctggtcgaa ctggtcggaa cgggaggcgt
1614781 tttcgtctcc gacggctttg gggtggtgca ccgcaagcaa gcctcggtct atgacatcgc
1614841 aaccctgttg ccgcactacg ccggcacgct ggtcgccgac gagatgcggg tactggagca
1614901 gttgaccagc tcgacccagc ggccctatgc ggtagtgctc ggcggatcaa aggtgtccga
1614961 caagctgggt gtcatcgagt cgctggcgac caaggcggac agcattgtga ttggcggcgg
1615021 aatgtgcttc acattccttg ctgcacaggg attttcggtt ggcacatcgc tgctggaaga
1615081 cgacatgatc gaagtctgtc gcgggctgct ggaaacctat cacgacgtgt tgcggctgcc
1615141 cgtggatcta gtggtcacgg agaagttcgc cgccgactcg ccgccccaga cggtcgacgt
1615201 cggcgctgtg cccaatggct tgatgggcct ggatatcggg ccgggatcga tcaaacggtt
1615261 cagcacgctg ctgtccaacg ccgggaccat cttctggaac gggccgatgg gagtattcga
1615321 gttcccggct tatgcggccg gcaccagagg cgtcgccgag gcgatcgtcg ccgccaccgg
1615381 caaaggggcg tttagtgtgg tcggcggcgg tgactccgcg gccgcagtgc gcgcgatgaa
1615441 catccccgag ggcgccttct cacacatatc caccggcggc ggtgcctcgc tggaatacct
1615501 tgagggcaag acgcttcccg gcatcgaggt actgagccgt gagcagccaa ccggaggagt
1615561 tttgtgagcc gcaagccgct gatagccggc aactggaaga tgaacctcaa ccactacgag
1615621 gcgatcgcgc tggtgcaaaa gatcgcgttc tcgttgccgg acaagtatta cgaccgggtt
1615681 gacgtcgcgg tgatcccgcc gtttaccgac ctgcgcagcg tgcaaaccct ggtcgacggc
1615741 gacaagctgc ggttgaccta tggtgcacaa gacttgtcac cacatgactc cggtgcctat
1615801 acgggtgacg tcagcggcgc ctttctggcc aagttggggt gcagttacgt tgtcgtcggg
1615861 cactccgagc ggcgcaccta tcacaacgag gatgacgcgc tggtggccgc caaagccgcc
1615921 accgcactca agcatggctt gaccccaatc gtgtgtattg gcgagcacct cgacgtccgc
1615981 gaggcgggaa atcatgtggc ccacaacatc gaacagttgc gtggatcgct ggccgggcta
1616041 ttggccgagc agatcggcag cgtcgtcatc gcctacgaac cggtctgggc gatcggcacc
1616101 gggcgggtgg ccagcgccgc cgacgcccag gaggtgtgtg cggcgatccg aaaagagttg
1616161 gcctcgttgg cctcgccgag gattgccgat acggtgcggg tgctctacgg cggctcggtg
1616221 aacgccaaaa acgtcggcga catcgtggcc caggatgacg tcgatggtgg cctggtcggc
1616281 ggggcgtcgc tggacgggga gcatttcgcg acgctggccg cgattgcggc cggtggtccg
1616341 ttgccgtagc ggatcgcggg cgtgctacac ccgtagacct tcgagtaggg ccataaatgc
1616401 gcgttcgacc tcgactctgg tccggtcttt gtccgtcgcg tccgcgatct gcagcgcgga
1616461 ttcggttagc gcggccagca gcagatgcga aagtggtggc aacggtacgc gctgaatcac
1616521 cccggcggcc atcccgcgtt cgagagcccc gaccagcaga ccaagcccta gcgcatgtcg
1616581 atccggcgcc attcgcccca cccgagcact gacgggccgt caatcgcaat gacctgcagc
1616641 gcatccggtt tggtcgccgc gtcaaggaag gcgtggaagc cgacgaccag cagatccagg
1616701 cgtcggtgac cttcgctatg gcggcttcga cgtcggcgac caggtcggct tcgacaacct
1616761 cgagtaccgt ctggaacaga tctttcttgc tgtcgaagtg gtagtccagg gcgccacggg
1616821 tgactcgggc acgggtgacg atgtcttcga tcgagacgtc accatagtcg cgccgcgcga
1616881 ataggtaacg gccagcgtcg acgagggctc gacgcgtcgc gtccgtgtgg tccgagcgcc
1616941 tgctggccgt catttcgacg tcaagcccgg cttcgcatgg ttgtcaacca gccacgccag
1617001 gccgacggat gcttgactac cttgatcaac agtgggagcg agtcgaaata gctcacgcgt
1617061 tctacggcct tgtcgccacg cagcaggaac cgatcgacga ctggccactc gacgacctcg
1617121 ctgccgagcc gtgctatcag ccggaactcg atgaacacca cgtcgcctgc ttggctccac
1617181 cggtcaactt ccccgtgcag gtcaggcagc aaacccagaa tccgagtgaa ctcccgctgg
1617241 gccgccccca ggccgtgcct cggcggtgac agtggccgta ccaggactac gtcgggatga
1617301 aggtgatcgg tcagtctatc cggcgacggc gccttccaga agtcggcgaa cccttcgacg
1617361 aatgcgttgg atgcgctcat ctgcatggcc ctttcggtgt ttgttcgctc gacagtctta
1617421 ctgcgtaagc ctgggggcga attcagcgga catcgttgct tatcggtagg aagctacggc
1617481 cgtcacagtg gtctcagcag cgggggaata cacattttgc ccgccccggc gcgacaactc
1617541 ggttgaagtc atgcccggat cggcatgttt ggccacgaac ggaatcgcga cagcgccacg
1617601 gcgtcgagcc tcgccatgca cctagccggc gcctttgaac tcgtgagcgg accgaagtgg
1617661 accgcctgtc gcttcgaggc gggcacagtg cgtattccct cgcaagggaa gcgccggtgg
1617721 caggcgtgac agccgcggtc agtgcacgcc tcaaagccga tgaggcgcga cggcctgggt
1617781 tctacgcggc aggcagcggt ccgctgccgc aggttcgggg gagtacgcta cccgtcatgg
1617841 aattggccct gcagatcacg ctgatcgtca cgagcgtgct ggtggtgttg ttagtactgc
1617901 tgcaccgggc caagggtggc gggctatcga cactgttcgg cggtggtgtg cagtcaagcc
1617961 tgtccggctc gacggtggtg gagaagaacc tggaccggtt gacgctgttc gttaccggca
1618021 tctggctggt gtccatcatc ggcgtggcgt tgctcatcaa ataccgctag cgctggtcgg
1618081 ctaccgccga ccggaccggg ggaagcggta gctcattgcc gattacgact tggtgcagcg
1618141 caggattctg ctgaccatga ccgggctggc cagcgcgctc agaaacagtg gttagtcggc
1618201 ctgaccggtc acccgtgctt tccttgcgcg ccattggcgc cgccgatccc gtcgggcaca
1618261 ccgacgccgc caggtccgcc ggtgccgccg tcgccgccaa agccgggatt gccgccacct
1618321 tggctgggcc cgccgtcacc gccgttgccg ccggcgccgc cgttaccgcc ggcgccggtg
1618381 ccgcctccgc ctgccccacc cgcggcgccg ttgccgccgt tgccgccgtt gccggcttgg
1618441 cctttgccgt cgaggctttc gatatagccg ccggtgccgc cggtgccgcc tgcgccgcca
1618501 gcgccgccgg cgccggcgct gctgccattg ccgatggtca atgcgctggc gccgccggtg
1618561 ccaccgacgc cgccgttgcc gccggtaccg cctttgccgc cgatcattga gctgccgccg
1618621 ccggtgccgc cggcgccgcc gtcgccgccg gcgccgccgg cgccggcgct gctgccgccg
1618681 atgccagctg tgccgccagt accaccggcg ccgccggtgc cgccgtcgcc gccgatgccg
1618741 ccagcgccta gcgccgtgcc gccgtcgcca ccttggccag cggtgccgcc gttgccgccg
1618801 gcgccgccat tgccgaacag ccggccacca gccccacccg cagcgccgtt gccgccgtcg
1618861 ccgccacggg cgccgttggc accgctgtta ggactgtcgc cggcaccgcc ggcgccgccg
1618921 tccccgccgg tcccaccggc gccgccggtg ccgaacatcc cagcagcacc accggcatca
1618981 ccgccaccgc cgttaccgcc agggctggcg gggacggggg ggaggccgcc gccgccgtcg
1619041 gcgccgctgg cgccagtacc gccgttgccg ccggcgccgc cgttgccgct tagccagcca
1619101 ccggctccac cggcgccgcc ggctccaccg gccgcgccgg ttccggccgc cgggctgtaa
1619161 ccggcaccgc cggccccgcc gttaccgaac attccggcat ccccgccgtt gccgccgttg
1619221 gggtgggcgg cgtcgccggc tccgccgttc ccgccgttgc cccacagcaa cccgccggcc
1619281 ccaccgtttt gaccgggcag cccgtcggcg ccgttgccga tcagcggacg ccccagcagt
1619341 gtctgggtgg gcgcgttgat ggccgcgagc acctgttgtt cgagggcctg caagggggag
1619401 gcgttggcgg cctcggcggc ggcatacgag cccacgctcg cggttaaggc ctgcacgaac
1619461 tgttgatgaa atctggccat ttgggcactg agcgcctgat agtcgcgggc gtagccagaa
1619521 aacaacgacg cgatggccgc cgacacctca tcggccccgg cggccaggac accagccgtc
1619581 gtgggtgccg cggctccgtt ggccgcgcta agcgccgcac cgatgctcgc cacatccgct
1619641 gccgccgctg acaacattcc cgggactacc atcacgttcg acatcgctgc agtctaaaac
1619701 ctggtgccat cgttgcgacg caaaacaatc gacatgctta ccatttctga gctcaactag
1619761 ctgctaggtt gccgcactag actgctgcaa atgcaggtct atacgtcggc aacgcactgg
1619821 ggcgtgttca ccgctcgggt gcacggcggc gacattgcgg ccgtggccgc gctcgccagt
1619881 gacaccaacc cggctccgca gctgcaaaac ctgcccggcg cggtacgtca ccgcagccgc
1619941 atcgccaacc ccgccgtacg gcgcggatgg ctgcagcatg gcccggggcc cagctcggct
1620001 cgcggcgccg aagagttcgt ggaggtcagc tgggacgagt tgatcgagct gctggcttcc
1620061 gagctgcgcc gtaccgtcga ccgctacggc aacgaggcga tctatggcag ctcctacggc
1620121 tgggccagcg ccggacggtt ccaccacgcg caaagccagg tgcaccggtt cctcaacatg
1620181 ctcggcgggt acaccgcatc ccggcacagc tacagcgccg gcgcgtccga agtgatcttc
1620241 ccgcatatcg tcggcgcggc cctgttcgaa gccctggccg agaccacgac ctgggatgtc
1620301 atcgtcgacc acaccgcgct gttggtggcg ttcggcggat tgccggtgaa gaacaccgcg
1620361 gtgatgcccg gcggtaccac cgctcatccg gaccgcgact acgtcggccg gtaccgggct
1620421 cgcggcggtc ggctggtgtc ggtcagcccg ctacgtgacg acatcgccgc gatcgccggt
1620481 ccgctcgacg atcgatgtcg ctggcttgcg ccggtgcctg gcaccgatgt ggcgatcatg
1620541 ctcgggctgg catacgtgct ggccaccgag tcgctggccg atcgcgcgtt ccttggcagg
1620601 tattgcaccg gctacgaacg cttcgagcgc tacctgctgg gcctggatga tgggattccc
1620661 aagacacccg aatgggccgc cgcgctgtcc gggctcgccg ccggcgatct gcgagatctg
1620721 gcccgccgga tggccgagca ccggactctg atcaccacca gtctgtcgtt acagcggata
1620781 gagcacggcg agcagaccgt gtggatggcc gcgaccctag cggcgatgct gggccagatc
1620841 gggcttcccg gagggggttt cggtcacggc tacagcagca acggcgtcgg caacccgccg
1620901 ttggcgtgcg gcctgccggc attgccgcaa ggcaacaatc cggtgtcgac gttcattccg
1620961 gtggcggcga tcagtgagct gctgcagcgg cccggccagc ggctggccta caacggccga
1621021 ttgctggagc tgcccgacat caagtgcgtc tactgggccg gtggaaatcc gttccaccac
1621081 caccagaacc tgccgcggct gcgtcgtgca ctgtctcggg tagacacgat cgtggtacac
1621141 gaacagtatt ggaccgcgat ggccaaacac gccgacattg tggtgccaac caccaccagt
1621201 ttcgagcgcg acgacttcgc cgccagcaag accaatccca ccttgatcgc aatgcctgcg
1621261 atggtgccgc cgtatgccaa cgcccgcgac gactaccaca cgttctccgc gttggcccac
1621321 cggctggggt tcggcaagca attcaccgag ggccgcagcg cgcgcgagtg gctcgagcac
1621381 atgtacgaca agtggtcggc cgagctggat ttcccggtgc cgtcattcgc cgaattctgg
1621441 cggaccggcc ggctggaact accgaccaga accggtttga cgtggcttgc cgatttccgg
1621501 gccgacccgg cggcccatcc gttggggaca cccagcgggc ggatcgagat cttctcggac
1621561 acggtcgacg cgtttgcctt gccggactgt gccgggcacc ccacctggta tgaaccgtcc
1621621 gaatggctag gcgggccgcg ggccgcgcgc tacccgctgc atctgatcgc caaccagccg
1621681 cggacccgac tgcacagcca gctcgatcac ggcggcgcca gcatggcatc gaaaatccgt
1621741 ggacgagaac cgatccggat tcacccggat gacgccgcgg cccgtgagct tactgacggc
1621801 gacatcgtgc gcgtgttcaa cgaccgcggc gcctgcctgg cgggtgtggt gatcgacgac
1621861 gggctacggc ccaaggtggt gcaactgtcc accggtgcgt ggttcgatcc cgccgatccg
1621921 cgcgacccgg actcgatgtg tgtgcacggc aatcccaatg cgctgagcaa cgattccggc
1621981 acgtcgtcac tggcccacgg cagcaccggc cagcatgtct tggtccagat cgagaggttc
1622041 actggcgaac tgccgccggt gcgcgcccac gagccaccgc ggctggctta gcgccggacg
1622101 tcgacttgtt gggcgcgaaa cgccgcaatg gaccgaacga ctcgacgtaa gtgtgccctg
1622161 ctggtgtcgg ctcgagtcgc agcacgggtg agcaccacgt gcgccactag ccctgagcga
1622221 agtgtcgctg caaccgccgg tgccgatgac cgaagagcgc gcgcaaccct gccgcgatga
1622281 gcggcgcggc aaacctgagt ccggcacgcg tctggaacgt gatgcggtcg cggacaatcg
1622341 ttttcgtgtc accctcgggc gtcacggtgc gttcgtgctg ccattgccgc atgctcagca
1622401 tcgtcgaatc ctcgcgaaac cgccgtcccg gctcgagctc ggcgatgctg agccggtcat
1622461 agtcgaatgg caacacaccg aacagtcgca gccaggcacg tccgatcggc gcgccgatcg
1622521 gcaccgtgtc gacggtcatc cctttcgcgc cgcgaggcac cgacatcgtc atccaggggc
1622581 gcaactcatc gttgatgccc tccggggtga cgacccgttg ccacacctgc tcggcaggtg
1622641 cggcgacgac gctttgccgt tcaatgagca ccggttcagc gtatccgacc acgcggcgcg
1622701 gtggggctac gtctccctcg cctcggtggc tgcctaaagg ccgttccgtc ccgggttgag
1622761 ttctgcgatg cagaggtggc agatcgtcaa tgcgggcgag aatttgttcc ggcctctgtt
1622821 gatgcgggtg acatcggaag gtgtgggtaa agggatcagc ccgagatcat gcaatcactg
1622881 tcctgacaac cagattcagc acggcctggt aatcgacagg attctgggac tatcagactc
1622941 cagcatcacg gttctcaccc gggcccaggt cgaggcgatg gtcgcggcgc tgccgcgaag
1623001 ctactgattc cgcgcagctg ctctgtcagg gccgctgact tttctctcgg tcatcgtggt
1623061 cgcaggcgcc gcactcggtg tcttcgggtg gggaagcgcg acctcgaagg ccactgaaac
1623121 gccttacgga gacgcgacga accaaatgcc gacgaatacg gcgaggccgg tggctaccgg
1623181 gagcctgcca cagaggatcg cccaacctgc ccagatcgtt gcctggccga ggaacatcgg
1623241 gttccgcgag aacgcgtagg gacctccagc tcctcgatga cccgcctcag ttcgtcggct
1623301 cgtgcacggt ccggtttcgg agccggtcca acacgccgcg aaccgcgtgc tcggtgaccg
1623361 acagcggtga catcaccgtt tcgccgaggc tcacgatgta gtcgatccga tcgacgatgg
1623421 cttccaccgg ctcgaccaac acgatgagcc gtttcgcgag atcgtccagg ctgtgcaggg
1623481 taccttcgag atggtccaga ccgtcctcca agcgctccac ggtgctgttc agctgtgaca
1623541 gcgagctgtt cagctcggcc atggtcttac ccagaccgtc caggacgtct tcgacctgct
1623601 ccaccgtctt gtcggcgttc aatgcggcct gggtgagggt tttcattcgc cgtcgcacgg
1623661 gcgcggggcg gccgcttctg tctgccatga cggtcattat gaccctgacg cggttaactc
1623721 ggaagcttgg cggcggcgtc gcggtccagc agccagagcg tgttctgacg cccgacggcc
1623781 ccggccgccg gtaccgaaac cggatcggcg ccgccgatgg ccgcggccac ggcgtcggcc
1623841 ttacccggcc cggaaaccag cagccacacc tcgcgggaac gctgaatcgc cggcagggtc
1623901 aaggtgattc ggcgtggcgg cggtttcggc gagtcgtcga ccgccaccac catgcgggtg
1623961 ctctcgagga cggcggggct gtgcgggaac agcgagttaa tgtggccctc gggccccatg
1624021 cccagcaggt ggacgtcgaa attcggcgcc gggtcacctg gtgcggcact ggcggccagc
1624081 acctgttcgt aggccagggc cgcggcgtcc agatcgccgc cgaagtcacc atcactggcg
1624141 gccatcgggt gcacctggtt cgatggaatg tcgacgtgat tgagcaacgc ccgccgggcc
1624201 tgcttgagat tgcgctcgtc atcgtcttcg ggaacgtagc gttcgtcgcc ccagaacagg
1624261 tgcaccttgg accattcaat ctgctgtgct tgggcgctga ggtagcgcag aagcgcaatc
1624321 ccgttgccgc ccccggtcag cacgatcagc gcctgccctc tggccgccac cgcggccccg
1624381 atggcgccaa ccaagcgctt acccgcggcc gcgaccagaa tgtcgctatc ggggaagatc
1624441 tcgatgctac tgctcaccgg tactgcacct tcttgattcc ctcgagcgcg gcgcagtaga
1624501 tttcgtcggg gtccagccgg cgcaggtctt cggctaggca ctcaccggtt accctgcgcg
1624561 ccaaaggaac cagagcgtcg ggcttgcccg tccgggtcag ggtggccgtg attccctcct
1624621 ggggacggct tagcacgatg gtctcgctgt tgcgcaccag ctcgactttg agttcgccga
1624681 ccgcccgtcg caccggacct tcgatccggc tggctagcca gccggctagg acgtcgagcg
1624741 ccggttcggt cttcaagccg gacaccagcg ccgactcgat cggctcgtgt cgcggctggt
1624801 cgacggccga cgtgagcagc gcacgccaat aggtgatgcg gctccaggcc agatcggtgt
1624861 cgccggcgcc gtagccggct agccggctct tgatggccga cagcgggtcg attgcgttgg
1624921 tggcgtcggt gatgcgccga attgctaact tgcccaacgc atcctgtgct ggcaccgccg
1624981 gtgcgatgtc gggccaccac gccaccaccg ggatgtcggg cagcaggaag gggataacga
1625041 cgctgtcggc gtggccggcc agtggcccgg acagccgcag caccacaaac tcgccggcgc
1625101 cggcgtcagc gccgacccgc agttgtgcgt ccagccgcgg tctgtcggcg tacggatcgc
1625161 cccgcatcgt tacgatgatg cggctgggat gctcatggct ggcgtcgttg gccgcctcga
1625221 tggactcttc cagcatggct tcgctgtccg gcgcaatgat gagcgtgagt acccggccca
1625281 tcgcgacggc gccgatcttt tcgcgcagct cgtcgagctt cttgttgacc gcggtggtgg
1625341 tggtgtcggg caagtcgaca atcatctgcg ccgctcctcc tcatcgcttc gctctgcatc
1625401 gtcgccggcg cggatcacta tggccgccgc cattcccggc cggtgcggcg cagcatctcc
1625461 aaggatgatt ccggacccca ggtacctgcc tcgtaggcgt cgggcgtccc gtgtgccgcc
1625521 caatgttcca acgctggatc gaggatctcc cacgccagtt cgacctccgc gttgaccgga
1625581 aacagcgagg gctcgccgag caggacgtcg aggatgagcc gctcgtaggc ctccggtgaa
1625641 tcttcggcga atgccgagcc gtaggagaag tccatgttga cgtcgcggac ttccatggcg
1625701 gtgcccggca ccttggagcc gaaccgcaat gtgacacctt cgtcgggctg cacgcggatg
1625761 accatcgcgt tggtgcccag ctcgtcggtc atggtggcgt cgaacggcag atgcggcgcc
1625821 cgcctgaaga ccagagcgat ctcggtcacc cggcggccca atcgttttcc cgttcgcaga
1625881 tagaacggca cgccggccca ccggcgcgta tcgacttcca gggtgatagc ggcgaaggtt
1625941 tcggtggtgg agtcctcggc gaacccctcc tcgtcgagca gcccaaccac cttctccccg
1626001 ccttgccagc cggcggcgta ctggccgcgg ctggtggtct ggtcgagtgg ctcggcaagg
1626061 cgggtggccg agagcacctt gatcttctcg gcctgcaacg ctgccgggtg gaagctgacc
1626121 ggctcctcca tcgcggtcag cgccagcagc tgcatgagat ggttctggat gacatcgcgg
1626181 gccgcgccga tgccgtcgta atagcccgcg cgcccgccca ggccgatgtc ttcggccatg
1626241 gtgatctgta cgtggtcgac gtagtgcgca ttccagatcg ggtcgaacag ctggttggcg
1626301 aaccgcagcg ccaggatgtt ctgcaccgtc tctttgccca ggtagtggtc gatgcggaag
1626361 accgcttcct ccgggaagac cgcgttgacc gccttgttca gctcgcgtgc gctggccagg
1626421 tcgtggccga acggcttctc tatcacgact cggctccacc ggtcgccttg cgggcgggcc
1626481 aggccggact tgtgcagctg ctcacacacc accgggaagg atttgggcgg gatcgccagg
1626541 tagaaggcgt ggttgccgcc ggtgccgcgc tcggcgtcga gcttctccag cgtctcggcg
1626601 agttgggcga acgcgtcgtc gtcgtcgaaa gtgcctggca caaaacggaa tccctcggcc
1626661 agccggtccc agttctgttg ccgaaacggt gttcggcagt gctcttggac ggcgttgtac
1626721 accacttgac cgaaatcctg ggtgctccag tctcggcggg caaaccccac cagcgagaat
1626781 gtgggcggca gcaggccgcg gttggccaaa tcgtagacgg ccggcatcac cttcttgcgg
1626841 gccaggtcgc cggtgacgcc gaaaatcacc atgccgcacg ggccggcgat tctgggtaat
1626901 cgcttgtccc gcttgtctcg tagcgggttg cgccacgacg ccgcggcgtg ggccggtttc
1626961 attgggcagc ggtgtcgaga tgcgcccggg tttcctggag tagctcgttc caggaggcct
1627021 cgaacttccg cacgccttcc tcctcgagga cggcaaacac gtcggtgagg tcgatgccga
1627081 tcgcccccag ctggtcgaac accgcctggg catcggatgc agttccggtg accgtgtcgc
1627141 cttggatcac gccatgatca gcgacggcgt caattgtctt ttccggcata gtgttcacgg
1627201 tgtgtggggc gaccaactcg gtgacgtaga gggtgtccga gtaatcgggg ttcttcacgc
1627261 cggtggaagc ccacaacggg cgctggaccc gggcgccgtc gaccttgagg gaccgataac
1627321 gatcgctgtc ttcgaagacc tcccggtagg tggcataggc caggcgggca ttggcgacac
1627381 cggcctggcc gcgcagttcg agcgcttgcc gcgagccgat tctgtccagc cgcttgtcga
1627441 tttcggtgtc cacccgggag acgaaaaacg atgccaccga atggatcttg gacaggctgt
1627501 gtccggcttg ccgggccttt tccatcccgg tcaggtaggc gtccatcacc tcgcggtacc
1627561 gctgcacgga gaagatcagc gtaacgttga ccgaaatccc ttccgccaga acggcactga
1627621 tggcgggcag accggcctta gtggccggga tcttgatgaa aaggttcggc cggtcgacga
1627681 tcttccacag ctcgattgcc tgttggatcg ttttttcggt ttcgtgtgcc agccgcgggt
1627741 cgacctcgat cgacacccgg ccgtcgaccc cgtcggagtc ctcccactgg gggaccagca
1627801 cgtcgcacgc gctgcgcacg tcgtcagtgg tgacggtgcg gatggtggca tccacgtcgg
1627861 cgccgcgcgc ggccagctcg gcgatctggg cgtcgtaggt gtggccctcc gacagcgcct
1627921 tctgaaagat cgacgggttg gtggtcaccc cgacgacgct cttggtgtcg atcagctcct
1627981 gcagattgcc cgagcgcagc cggtcccgcg acaggtcatc cagccacacc gatacccccg
1628041 cggcgctcaa tgcggccagg ttggggttct gagcggtcat cggtaatcac ccttcctcag
1628101 ttatccagcg ctcgttcggc ggcggcggcc acggcctcgg cagtgaagcc gtactcgcgg
1628161 aacaaggtct tgtggtccgc ggattcgccg tagtgctcga tcgagacgat ctcgcccgtg
1628221 tcgccaacca gctggtgcca gcattgcgcg acgccggctt cgacggccac ccgcgccgac
1628281 accgtcgggg gcagcaccgc gtcgcggtac tcgtagggtt gggcctcgaa ccactccagg
1628341 cacggcatcg acaccacccg agcgaggatg tcgttgtccg ccagcaacgt ctgcgccgcg
1628401 accgccagct gcacctccga gccggtggcg atgagaatga cgtcgggttc ctcgcccggt
1628461 tgcagaccac cggcgtcact cagcacgtaa ccgccgcggg caaccccctc ggcgtcggtg
1628521 ccgtccagca ccggcacacc ctggcgggtc aggatcaacc cgaccggccc gctgccgttg
1628581 cggcgggcca ggatcgtgcg ccaggcgtag gctgtctcgt tggcatctgc cgggcgcacc
1628641 accgacagcc gggggatcgc gcgcagcgcc gagaggtgct cgatcggttg atgggtgggc
1628701 ccgtcttcgc cgaggccgat cgagtcgtgc gtccagacgt agatggtgtc gatgtccatc
1628761 aacgccgcca gccgcaccgc cgggcgcatg tagtcggaga actgcaggaa ggtgccgccg
1628821 taagcccggg tgggtccgtg cagcacgatg ccggacagga tggcacccat cgcgtgctcg
1628881 cgaacaccga agtgcaaggt gcgaccatac cagtgcgcgg tgtactcctt ggtggaaatc
1628941 gagggcgggc caaaggagtc ggcgcccttt atcgttgtgt tgttgctgcc cgccaggtcg
1629001 gccgaaccgc cccacaactc gggcagtttc ggcccgagcg cggacagcac cgcacccgag
1629061 gccgcacggg tggccagcgc cttggacccc ggttcccagt ggggcaagtc ggcgtcccag
1629121 ccgtcgggca acttctgcgc gagcagccgg tccagcagcg ccttgcgctc gggttcacgc
1629181 cgcgcccagg catcgaattc gagctgccag cgttcgtggg cctgtttgcc gcgggccacc
1629241 agccctcggg tgtgggtgag gacgtcctcg cggacctgga acgtcttgtc cggatcgaag
1629301 ccgacgatct tcttgactgc ggccacctcg tcgtcgccca gcgccgcgcc gtgcgccttg
1629361 ccggtgtcca tcaggttcgg cgccggatag ccgatgacgg tgcgcagcgc gatgaacgag
1629421 ggccggtcgg tgaccgcctg cgcattggcg atggcctcct cgatgccgac gacgttctca
1629481 ccgccctcaa cctcttgcac gtgccagccg tacgcgcggt agcgggccgc ggtgtcctca
1629541 cacagcgcga tgttggtgtc gtcctcgatc gagatctggt tgcggtcgta gaacacgatg
1629601 aggttgccca gttgctggac cgcggccagc gacgacgcct ccgaggtcac cccttcttcg
1629661 atgtcaccgt cggaggcgat gacatagatg tagtggtcga aggggctggc gcccggttcg
1629721 gcgtccgggt cgaacaggcc gcgctcgtag cgcgaggcca tcgccatccc gaccgccgac
1629781 gccagtccct gccccagcgg gccggtggtg atctcaacgc cgggggtgtg gcggaactcc
1629841 gggtgtccgg gggtcttgga tccccaggtg cgcaacgact caatgtcgga cagttccagg
1629901 ccgaagccgc cgaggtagag ctggatgtag agggtcaggc tgctgtgccc ggccgacaaa
1629961 acgaaccgat cgcggcccag ccagtgtgtg tcgctgggat cgtgacgcat tgtccgctga
1630021 aacagcgtgt aggccaacgg agccaggctc atcgccgttc caggatgacc gttgccgacc
1630081 ttttggacgg catcggcggc caatacccgg atggtgtcga cggcagccga atcgatctcg
1630141 gtccagtagt cgggatggcg cggtcgggta agcgcggaga tctcttcgag tgtggtcaca
1630201 aattcagtcc tcgagtcagc aagatgatca gtcctcaccc tagtgcggga atcccggcgc
1630261 ttgcagtgcc gcatatccgg gtacccatcc gggccctgtg aaacgtaacc cgcgcgctac
1630321 ccacgcttcg cattcggtgc cgatatgccg aaaaatcacc gtcatcgacc ctgcggctct
1630381 gctgctgggg ctacgtcgaa caccgtacgt cgcagaagtg tggtgcgggt cgggcggccg
1630441 gcttaatcgc ggtgataatc ggttggtcgg cgatcaccgg catcatcggt tggccggcgc
1630501 tggtgatgct gttcgccggg cctcgcgtcg gcgagccggg caagccggtg cgcctgccga
1630561 tcccatggcg ggatgttggt gggtaccgcc cgaccggaag aagcatcgcg gcatgccggc
1630621 gtggcgagcc tcggggtcta cacgaattcg ccgccgccga gcccgccgaa gccaccgccg
1630681 ccaccggcgc cgccggcggt acctgtggcg atggaccccg ggctaccgag gccgccgaga
1630741 ccgccgagac caaggaggat gctgaagccg ccgccaccgc cctgcccccc gtggccaccg
1630801 gtcccaccgg tgcctgttcc aaagggcccc gcgtcgccgg tgccgccggt gcccccggag
1630861 ccacccatcc cgccccggcc accgacgccg gcaaaaccat tgccgccaaa gccgcccgca
1630921 cctccgttgc cacccatccc aggctgagag ccgttgtggc cggtgccgcc ggtgccgcca
1630981 gcgccgccgg tgccgccggt gttaccgttg ccgccgttgc cgccagtgcc gcctctgccg
1631041 ccggtgaggc cgccgttggc accctggccg ccggtgccgc cggtgccgcc ggtgccgccg
1631101 gtgccccagt cgccgggggt gccacctggg ccgctggaac cgccaagtcc tgcatcgcct
1631161 ccgcgtcctg catcgcctcc gcggcccccg ccgccgccgt caccaggtga ggtgacaagg
1631221 tcgccactgg cgccgttgcc accgttgccg ccgttgccgg gtgtcccgcc ggtcccaccg
1631281 ttgccgccgg ctccggtgag gccttggccg ccgttgccgc ctctgccgcc gttgccgcct
1631341 ctgccgccgt caccgccatc gccctcgttg gtgccgagga cgcccttggc gccggtgctg
1631401 ccggcgccgc cagtcccgcc gatgccaccg ttgccgccgt tggcgccggt gccgccgtta
1631461 ccgccgttac ccccgtggcc gccggggccg ccgtttccgc cgctggcagc gccgtggccg
1631521 ccgtgaccgc cgttgccgcc gtcgtgcagg atgctgccgg ccggccccgc cttgcctgcg
1631581 gtggagccgg tgccgccggg gccgccggca ccggcgttgc cggcgttgcc gccgtcgccg
1631641 cctcgcccgc cgccgccgcc ggcgaaggcc cctgctccct ggccgttgcc gccgttggcc
1631701 ccgtcaccgg gagcaccgcc gtcgccgccg gccccaccgg caccgcccgc gccgtcgctg
1631761 actacgcctt gaccgccgtt gccgccggcc ccgccgttgc cgccggcgcc gccgtgcccg
1631821 ccggcaccgc cgggttgtcc gggcgcaccc acggccacgc cgttggcacc ggcggcgccg
1631881 ttgccgccga atccgccgag gccgccgttg ccgccggcgc caccgttacc gccgttcagg
1631941 ccggccccgc cggccccgcc ggcgccaccg ttgccgccgg ggttaccgtt tggcccgttt
1632001 tcaccagggt tggtggcgtt ggcactcatg ccaccaaacg cgccgtcgcc gccgcggccg
1632061 ccgttgccgc ccgtgccggc gctgccgccg ttgccgccat tgccgccgtc gccgccgttg
1632121 ccgccgacca cttgggagtt gccgccgttg ccgccgtcgc cgccgtcgcc gccgctggtt
1632181 ggagtgaagc cgtgggcgcc cttggcgcct ggggtagagc cggcgccacc gctaccgccc
1632241 tgcccgccgg cgccggggtt accgccgtta ccgccgtgac cgccgttacc atcgccgaag
1632301 gcgaagttgc cgttggcgcc gttgccgccg tcaccggcga gcccgccggc cccccctttg
1632361 ccgccggacc cgccgacacc ctggattccg ttctggccaa agaggttccc cgccaaaccg
1632421 ccgggcccgc cttggccgcc gttaccgcct tgcgcgccgg gcccgccgtg gccgccgtcg
1632481 ccgcccttgg cgcccggcgt ggtggcgttg gcgccgttgg cgccgttgcc gccggcccca
1632541 ccggtcccgc cgtcgccccc gaagtctccg ccccggccgc cggccccgcc cgccccgcca
1632601 gccccgccgt tctggccgct cgtgccggat tcgcccgcgg tggtgggcga ggaaccggcg
1632661 acaccggcca tgccgtcccc gcctttgccg ccggccccgc cattaccaac aagcccgccg
1632721 ttgccgccct tgccgccggc cccgccggcc ccgccggcga cggtggcgtt cgcgccgttg
1632781 ccgccggtgc cgccgttgcc gccgctggtc ggggtggcgc cgcgggcacc gtctgcaccc
1632841 gcggtggatc cggcgccgcc gatcccacca gcaccaccga tgccgcggct accgccgttg
1632901 ccgccgttgc caccaactcc atcgccgccg ttatcgaacg tgcccttggc accgttgccg
1632961 ccatcaccgc ccatgccgcc ggcgccgccg tttccgccgg ccccgccggc acccatgctg
1633021 ccgtcctggt gggtggctgc aagcgcctta ccgccttgcc caccggctcc accgccaccg
1633081 ccggctccac cgttgccgcc cttgccgccg tcggtgccat ccgcgcctgc ccccaggccg
1633141 ttaaggccgg tggcgccggt ggcgccgttg ccgccgttgc cgcccttacc gccggcgccg
1633201 ccagcaccgc cgtcgcctgc ttgggctccg ccgtcgccgc ccttaccgcc agcgccgcca
1633261 gctccgccgc caccgccgtt agggtcgccg ccagaaggcg gggcaccggg ggcgccgttg
1633321 ccgccggcac ctccggcgcc gccattgccg accagcccgc cggccccgcc ggccccgccg
1633381 ttaccgccgg ctttgccgcc cgatgagaag tgggcgccgt tgccgccggc cccgccgttg
1633441 ccgccgctgg tggggctggc cccggccgcg ccgtgggcac cgatcgtgga gccggctccg
1633501 ccggtgcctc cggccccgcc ggcgccgggg tcaccgccgt tatccccagc gacaatcaag
1633561 gcacgagaaa atccggcccc gccggccccg ccggtcccgc caaccccacc ggccccgccg
1633621 gccccaccgg cgccggccag ccagccgccc cgccctccgg tgccgccatc gccggcgtcg
1633681 ccgccgaccc caccggacgt accgtgcggg gacaagtcct caccggctgc gccggccaca
1633741 ccctccgcgc cgtgtccgcc ggcaccaccg tgcccgccca cgcccaacag cccggccgca
1633801 cccccgacac cgccgtgtcc acccacacca ccgatcgggc cgggcccgcc ggcacctccg
1633861 tgcccgccgg ccccgtagag ggtcccgccc aggccaccgg caccaccggt accgccgacc
1633921 ccgccgggcc cgccgggccc gccgggcccg ccggttccgc cgaccccgaa cagtccggcg
1633981 ttgccgccgg ccccgccggt tgccccgccc agcaggctct gcccgccggc cccgccgact
1634041 ccaccattgc ccagcagcca gccgccgcta cccccggccc caccggcggc gccggcccca
1634101 ccggccccac cggccccgcc ggtgccgaac aacccggcgg ccccgccggc cccgccgact
1634161 tggccgggcg cgcccgagcc gccggcccca ccgttgcccc acaagatccc gccggccccg
1634221 ccggcctgcc cggtgccggg tgctccagcc gccccatcac cgatcaacgg gcgacccagc
1634281 aacgcctggg tgggcgcatt gagggcattg agcacgttgt gctccagcgt cgccaacggt
1634341 gcggcgttgg tcgcctccgc gctgacatac gagccgaccg cggcgcttaa cgtctgcgca
1634401 aatcggtcat gaaacgccgc cacctgcgtg ctgatcgcct gatactcccg agcatggctg
1634461 ccaaacagcg tcgcgatcgc cgccgacacc tcatcggcgc ccgcggccag cacgctggtg
1634521 gtcgaccccg ccgccgccgc attggccgcg ccgatcgatg acccgatgcg cgccacatct
1634581 aaggctgcgg ccgccaccgt ctccggggcc acgatcacca acgacatcac agacctcccg
1634641 ccacgcccct gccccttcgg caggtcacac tcctgccaga taagggtcgc gccgccacct
1634701 tgtccgattc caggtcaaaa tccccataac cagcacgaat ctgctgtgca cagtgcacat
1634761 tcgccctact atcggctcgt ggcattgcgg ctagcaacgg ttggtcttcg ggcccaatcc
1634821 ttagggcgtc acactgatca atcccagata gcgattttca tcgggctggt gtgaaaattg
1634881 tcctgaccgc ggttcgggct ggcgagcggt gccgatatgc cggcgaagtc gtgtgaatcg
1634941 accctgcggc tctgctgcca cagttacccg gtctaccatc gtgcgtagta gaagctgcgc
1635001 gcggctgcga ttcccgagga gttagtgcgt gaacgttcgc gggcgcgtcg cgccgcgccg
1635061 agtgactggt agggcaatga gcaccctgct ggcctacctg gcgttaacca agccgcgagt
1635121 catcgagctg ctgttggtca ccgcgatacc ggcgatgctg ctggccgacc gcggcgccat
1635181 tcatccgctg ctcatgctca acacgctcgt cggcgggatg atggccgccg ccggcgccaa
1635241 cacgctcaac tgcgtcgccg acgccgatat cgacaaggtg atgaagcgaa ccgcgcgccg
1635301 gcccttggcg cgggaagcgg tgccgacccg aaacgcgttg gcactcgggt tgacgttgac
1635361 ggtgatctcg ttcttctggc tatggtgcgc cacgaacctg ctggcggggg tgctggccct
1635421 ggtcaccgtc gcgttttatg tgttcgtcta cacgctttgg ctcaagcgac gcacgtcaca
1635481 gaacgtggtg tggggtgggg cggccggctg tatgccggtg atgatcggct ggtcggccat
1635541 caccggcacc atagcctggc cggcgctggc gatgttcgcg atcatcttct tctggacgcc
1635601 gccacacacc tgggcattgg cgatgcgcta caagcaggac taccaagtgg ccggggtgcc
1635661 gatgctgccg gcggtggcga ccgagcgtca ggtcaccaag cagatcttga tctacacctg
1635721 gctgaccgtg gccgcgacgc tggtgctggc gttggcgacc agttggcttt acggcgcggt
1635781 ggccctggtg gccggtgggt ggttcctgac gatggcccac cagttgtatg ccggggtgcg
1635841 cgccggcgag ccggtcaggc cgctgcggct gtttctgcag tcgaacaact atctggcggt
1635901 ggtgttctgc gcactggccg tcgactcggt gatcgcgctg cccacgctgc actgattggg
1635961 ggcccagttc cgctgcggtg ccggccctgc tcggccaacg tagtcagatg gttggatcgc
1636021 caccggcgcc accggcgccg cccgcgccac cagcaccgcc gctgccatct gggtccgtcg
1636081 agtcgccgag gacgccggcg ccgccattgt cgccaaatac cgtgagacct agcagggtgc
1636141 cggcgccgcc cttgccgccg gccccgccgt ttccgccgcc gccatcgccg atgatgtttt
1636201 ccccgccctt gccgccagcc ccagcgttcc cgccggctcc gccactggcg ccggtgccgc
1636261 cgggtgcaac ggcgttggcg ccgttaccgc cgttgccgcc tttgcccccg gtgtctgcaa
1636321 agtcgggggt cgcaccctgc gcggcgcggg tcacgccgtc accgctgagc cccccgagcc
1636381 cgccagcgcc gctgaagcca ggattgccgc cgttgccgcc atggccgccg ttggcaccgg
1636441 gtgcgacggc gttgccgccg gtcccgccga ccccaccgtt gccgccttta ccaccgtcct
1636501 ggccacgctc gcccgcggtg gtggcattgg caccctcggc accactacca ccgagcccgc
1636561 cgtctgcgcc gcggccgcca gtcccaccgg ccccgccatt gccggcgaga gttccgccgt
1636621 cgccgccggc gccgccctgg ccgccgttgc cgccgctatt gcctttgcca ccgactgcgc
1636681 ccgaatcgct cgcgttcgtc cctgcggcgc cgttggcgcc gttgccgccg gcgccgccgt
1636741 tgccgaccag cccgccatgg ccgccgggtc cgccgttggc gccgttggtg cccgcggtgg
1636801 tggcgttggc gccgttgccg ccggccccgc cgttgccgcc gctggtgggg gtggcgccga
1636861 tggcgccctg agcgccggtg atggagccgg ctccgccggt gcctccggcc ccgccggcgc
1636921 cggggtcacc gccatggccg ccggccccgc cggcacctgc gttgaaggcc tggttgccgg
1636981 ggccgccggc tccgcggtca ccgccgacgc caccagcgcc gccggtcccg ccggccccgc
1637041 cggcgccttg gccgcccagc aggctgatca ggccgccggc cccgccgggg ccgccagccc
1637101 cgccagcccc gcccatcccg ccgttaccac catcaccgcc gttatcccca gcgacaatca
1637161 aggcacgaga aaatccggcc ccgccggccc cgccggtccc gccaacccca ccggccccgc
1637221 cggccccacc ggcgccggcc agccagccgc cccgccctcc ggtgccgcca tcgccggcgt
1637281 cgccgccgac cccaccggac gtaccgtgcg gggacaagtc ctcaccggct gcgccggcca
1637341 caccctccgc gccgtgtccg ccggcaccac cgtgcccgcc cacgcccaac agcccggccg
1637401 cacccccgac accgccgtgt ccacccacac caccgatcgg gccgggcccg ccggcacctc
1637461 cgtgcccgcc ggccccgtag agggtcccgc ccaggccacc ggcaccaccg gtaccgccga
1637521 ccccgccggg cccgccgggc ccgccgggcc cgccggttcc gccgaccccg aacagtccgg
1637581 cgttgccgcc ggccccgccg gttgccccgc ccagcaggct ctgcccgccg gccccgccga
1637641 ctccaccatt gcccagcagc cagccgccgc tacccccggc cccaccggcg gcgccggccc
1637701 caccggcccc accggccccg ccggtgccga acaacccggc ggccccgccg gccccgccga
1637761 cttggccggg cgcgcccgag ccgccggccc caccgttgcc ccacaagatc ccgccggccc
1637821 cgccggcctg cccggtgccg ggtgctccag ccgccccatc accgatcaac gggcgaccca
1637881 gcaacgcctg ggtgggcgca ttgagggcat tgagcacgtt gtgctccagc gtcgccaacg
1637941 gtgcggcgtt ggtcgcctcc gcgctgacat acgagccgac cgcggcgctt aacgtctgcg
1638001 caaatcggtc atgaaacgct gccacctgcg tgctgatcgc ctgatactcc cgagcatggc
1638061 tgccaaacag cgtcgcgatc gccgccgaca cctcatcggc gcccgcggcc agcacgctgg
1638121 tggttgaccc cgccgccgcg ctgttggcta caccgatcga tgacccgatg cgcgccacat
1638181 ccgaggccgc cgcggccacc gtctccgggg ttacgatcac caacgacatc acagtccacc
1638241 cgccacgccc ctgccccttc ggcaggtcac actcctgcca gataagggtc gcgccgccac
1638301 cttgtccgat tccaggtcaa aatccccata accagcacga atctgctgtg cacagtgcac
1638361 attcgcccta ctatcggctc gtggcattgc gggaaacctc accgcgaata catgagctga
1638421 tccgcgaggc agcgcgaatc gccctcaacc cgacccagga atggctcgac gaattcgacc
1638481 gtgccattct ggccgccaac ccatccatcg ctgccgaccc cgccctggcc accgttgtca
1638541 agcgttccaa tcgggcgcat ctcatccatt tcgcggccgc caacctgcgc aatcccggcg
1638601 ccccggtgcc cgcgaacctt ggtcccgagc cgctgcgcat ggcccgtgat ctcgtgcgcg
1638661 tcggtttaga tgccttggcc ctcgacatct accgcatcgg acaaaacgtg gcctggcggc
1638721 gctggacgga catcgcgttc ggactgacct ccgaccccga cgagttgcac gaattactgg
1638781 atgtgccatt tcggacagcc aacgagttcg tcgacaccac ccttgcgggc atcaccaccg
1638841 agatgcaatt ggaacgcgac aagctcaccc gcgacgttcc tgccgaacgc cgcaaaatcg
1638901 tccagctgct catcgacggt gcccccatca gccgtgagca cgccgaagcg cgattgggct
1638961 accctctcga ccgatcccac accgccgccg tcatctgggg tgaccaggcc cagggcgacc
1639021 acagccacct ggaccgagtc gccgacgcgt tcggccatgc cggcggatgc ccgcacccgc
1639081 tggtcgtggt agccggcgcc gcgactcgct gggtgtgggt aaaagacgcc cccgggtttg
1639141 acatcgacct gattcacgag gtgctccatg acatacccga cgcgcgtatc gccatcgggg
1639201 ccaccgcgcc gggaatcgag gggttccggc gcagccaccg agacgcactc accaccgctc
1639261 ggatgattat ccggctggaa tcaccgcacc gagtcgcctt tttcaccgac gtcgagatgg
1639321 tcgcgttgct caccgaaaac gccgagggtg ccgacgactt catccaacgc accctcggaa
1639381 acctcgagtc ggccagcccg gctctgaaaa cgacgctatt gaccttcatc aaccagcagt
1639441 gcaacgcttc tcgggccgcg agacttctct tcacccaccg caacaccttg atgaaccgac
1639501 tcgagaccgc gcaacgactt ctgccccgcc ctctcgccga caccaccatt cacgtcgccg
1639561 tcgcactcga agcccagcag tggcgggaga agccaaccag cgatcctccg gcaaagaaag
1639621 agtcgaatgg caccaagatg cgttagcaag acagcgcagc acagaccgct acgctacggc
1639681 agcagcacga ccgagccgac cgtcttgcga gcctccaggt cctgatgggc gcgcaaggcg
1639741 tcggccagcg ggtaacgtcc gccgaccgcc acggtgatcg cttcgctgcc gatcgcgtcg
1639801 aacagctcag cggcccgcca gctgaactcc tcgccggtgc gggtgaagtg gaacagcgag
1639861 ggacgggtga ggtacaccga tccggcggca ttgaggcgct gcggatcgac cggtggaacc
1639921 ggaccgctgg cggcgccgaa cagtgctaat gtcccgcgga cagccaggct ggctaggctg
1639981 gcgtcgaagg tggtggcgcc gacaccgtcg taaacggctt gcacaccggt gccgccggtc
1640041 agttcgcgaa cccgcccggc gaactgccag gcatcctccg ggtagtcgag aaccacgtcc
1640101 gcgccggcat ccttggacag cttggccttc tccgccgtcg aaacggtggt gatcacccgc
1640161 acccccaggt gagtggccca ttgtgtcagg atcaagccga cgccgccggc gccagcatgc
1640221 accaagacgg tgtcaccacg cttcaccggg tacaccgact tcagtaggta atgcgccgtc
1640281 aggcccttca gcagcgccga agccgctacc tcagacgtga cgtcgtcggg gaccttggcg
1640341 gtcagagatg ctggcgctgt gcagaattcg gcgtaggcgc cgttggctga ggcgctgacc
1640401 acgcggtcgc cgacgctgat ggcggtgtcg gctgcggtaa cccctgggcc gacggcctcc
1640461 accgtgccgc atacctcgga gccgatgacg aacgggagtt cgcgcggata ttgcccggag
1640521 cggaagtagg tgtcgatgaa gttgacaccg atggcctcgg ccttgatcag gagctcgccg
1640581 tggccgggtt gaggttgcgg ctggtcgacg tggcgtaaga cgcctggccc gccggtttcg
1640641 gtgacttcga ttgcgtgcat gtggctatca tgcccgggca tgaagcttgc ccggccggac
1640701 gtcttccatc cgcgcgtcgt tttggcgggt tggccacagc agcccgccgg tgacggcgac
1640761 gatgctgggc tggttgcggc cctgcgccac cgcggcttgc atgctggttg gctgtcttgg
1640821 gacgatcccg aaatagtcca cgcggatctg gtgattttgc gggctacccg cgattacccc
1640881 gcgcggctcg acgagttttt ggcctggact acccgcgtgg ccaatctgct gaactcgcgg
1640941 ccggtggtgg cctggaatgt cgagcgccgt tacctacgtg acctgatgga tcggggggtg
1641001 ccgaccgtgc ccggcgaggt gtatgtgccg ggagagccgg tccggttgcc acgcaaaggc
1641061 caggtcttcg tcggtccgac catcggtacc gggacacggc gctgtagtgc ccggttcgct
1641121 gccgagttcg tcgcgcaact gcacgcggcc ggccaggcgg tgctcgttca gcccggaggt
1641181 tccggtgacg agaccgtgtt ggtcttcctt ggcggtgagc cgtcgcatgc gtttaccaag
1641241 caggccgaca cttggcgcca gaccgagccc gacttcgaaa tctgggacgt gggtgcggcc
1641301 gccgtggccg gcgcggccgc gcaggtgggt gttgacccag gtgagctgct ctacgcgcgg
1641361 gcccacatca caggtggaag ccgagatccc cggttgctgg aattgcaatt ggtggacccg
1641421 tcgctgggct ggcagtggct ggacccagac atccgcaatc ttgcccagcg tgacttcgcg
1641481 ctatgcgtcc agtcagcgtt ggagcggctg gggctgggcc cgttctccca tcgacgccca
1641541 tagcgcggcg gtggccgccg taaccgccgc ggcaccggcc acgtgaatgg cgaccagggc
1641601 ggcgggtacc ccggtgaagt attgcgtggt accgacggcg gcttgcgtgg caaccagggc
1641661 gagcagcacg gcgagtcgca ccagaatcgc ccgggtggca cccacggcca gcagcccgaa
1641721 acccaacccg atcagcagcg caaggtaggc aaccaacagc gacgaatgca tatgcaccaa
1641781 ggtggtgatt tcgactttca gccgcggcac ggtccggctg gggctgcgat ctcccgcgtg
1641841 cgggcctgcc gccgtgacta gcgtgcccgt caccagcacc gcggccaggt tcagcgcgct
1641901 gagcgccgtg agcgcacgca acgggctgac caccagttcg tggacgactc cgtcatcggg
1641961 ctggccgatc ttgacgtaga gcagcaccgc cagccacacc atcgtcatcg acgccagcag
1642021 gtggatggcc accgtccacc acagcagccc ggtgcgtacg gtgatgccac cgatcatcgc
1642081 ctgcaccacc gtcgacaccg gcatcagcca cgcgtaggcc aggacttccg tgcgccggcg
1642141 cgcccgggtg acgaccagca cggccagtgc cgcggctatc accaccgcaa acgtgaccat
1642201 ccggttgccg aactcgaccg cctgatggac ccgcggcacc tcggcgacca ccaccggggt
1642261 gaagctaccc ggaaaacact gcggccaggt cggacacccc aggcctgagg cggtaacccg
1642321 gacgattgcc ccggtgacgg cgatgccgcc ctgggtgagg atgacgattg cggcgatgac
1642381 ccgctggaca cgcaggctgg gagacaccgc ccgatcgtaa ggcaccaaaa actacacgct
1642441 gtagtacggg cggaccggtg tcgaaactgc aaccacgcac cgatgcgtcg gcgtgtcttg
1642501 tgcgtggttg cagtgtcgcg aagccgggcg gccggttcag gtgaaccgga accagcgcag
1642561 tgcggccagt gcggccagcg cgccccacac cgctaggacg acgatcccga accagtccac
1642621 cgacacggtc atggcctgcg acagcgcctc ggtgagcgcg cccgacgggg taacccgagc
1642681 cacccatttg aacgccgtcg ggatcacgtt cgactccaag gtcagcgcac cgaaaccggc
1642741 gaatacgaac cacatcaggt tggcgacggc gagaacgatc tcggctcgca aggtgccgcc
1642801 gagtagcagg ccgagcgccg caaagcccgc ggtacccagc gcgatgatcc cggcgcccaa
1642861 tgtcagggcc gtcagcgccg gccgccagcc gagcgcaaag ccgatggcgc ccaagatgat
1642921 ggcctgcaag aacaccacgg caaccactgc cagcgacttg ccggcgatga tcccccaaac
1642981 cggcagcggg gtagcaccga gtcgtttgag ggcgccgtag cggcgatcga acgcgaccgc
1643041 gatggcttgc ccggtgaatg cggtggagat caccgcaagc gccatgatga ccggaacaaa
1643101 ggtggcggcg cggttgtggc cgaacgagcc catcggcagc aaagtcagcc cgaccagcag
1643161 ggtgatcggg atgaacatgg tcaacagcag ttgctcgccg ttgcgtaaca gcagcttcaa
1643221 ttccaggctg aactgtgcgg caagcatcag ggggacggcg ttggggcggg ggtccgggct
1643281 gaaggtgccc gcgggaaaag cggggcgatt ggtttgggtc actgccgcaa cttcctgccg
1643341 gtgagatcca ggaacacgtc ttcgaggctg cgttgctcga cccgcatgtc ggtggctagc
1643401 acgtcgattt gtgcgcacca cgcggtgacc gtcgccagca cctgcgggtc aaccggacct
1643461 tcgaccaggt actcgcccgg ggtcagctcg gtggcctggt agccctcggg cagtgccgag
1643521 gccagcagcg acaggtcgag ccgcggcggc gcggtgaacc gcaactggtc tttggcgccg
1643581 ctgcgcatca gttctgccgg tgtgcctgcg gccaccgtca ccccgtggtc gatgatcacc
1643641 aaccgatcgg cgagttcctc ggcctccttg agatgatgcg tggtcagcac cacggtcacg
1643701 ccatcgcggc gcagcgcgtc gatcaactcc cacaccagta cccgggcatg ggcatccatg
1643761 cccgcggtgg gctcgtcgag gaacaccagt tggggacgcc cgaccagcgc gcaggccagc
1643821 gcgagtcgtt gctgctgccc gccggagagc cgtcgatagg tggtgcgggc ggcctcggtg
1643881 agacccaagg tgtccagtag ccagtgcggg tccagcgggt tggcggcgta ggacgcgacc
1643941 agatccagca tttcgccggc gcgtgccgcc gggtagccgc cgccaccctg caacatcacg
1644001 ccgatgcgtg cgcgcaggcg tgcgttgtcg gtgatcgggt ccagtccaag tacctcaatg
1644061 ctgccggcgt ccgggcggac gaagccctcg cacatctcga cggtcgtggt cttgcccgcg
1644121 ccgttggggc ccagcagcgc catcacttcg gcgtcatgca cgtcgagatc gaggttggaa
1644181 acggcggtta ttgacccgta tcgcttacat accccgcgaa gccgcagtac cacctcgggg
1644241 gtgtctgggg cgcggttcac gagcgccgct cctcctcatc gcttcgctct gcatcgtcgt
1644301 cggcgcggtt cacgagcgcc gctcctcctc atcgcttcgc tctgcatcgt cgtcggcgcg
1644361 gctcacgtgg aatcagcgta ggcgtcgggc gctgccgtcg gccggcgggt cgcaggggtc
1644421 ttgctggccg actccgcggc ggtgaccact tgctcggctg caagtggccg ccatggtaac
1644481 cgggtgtagg tcagggcaat caggaggatc acgatgatgg cgctggccgc ggtcgcatcc
1644541 acgatctgaa acagcgcgaa gcggtcacca ttggcggtcg gaccgaaaat tccgacgatg
1644601 agggtggcca ggattgccgc tacccgaaat cccgggcggg ttgcccaggc ggccagcgga
1644661 attatcgccc acagcaggta ccagggctgc acgacgggaa acagcagcac ggtgacagct
1644721 agcgcaacgc ccaggccgcc gatcgggtgc agccggccgc ggagcacggc caataacagc
1644781 cagcacacca tcaccgtgat gatcagcacg ccgatggcgc gggtgagtga caacacggcg
1644841 gtggtgtgat cacccaggcc cagcaggatg ccgacgtgcc cggtgcccag ggccagcagt
1644901 gtcggcggcg acatccagct gcgcaccaca ttggcggtgc ccagcgtgtt gatccagccg
1644961 aatccgagac cgctggccca acccaggatg gccattatcg ccagcgttag actcgccatc
1645021 acagcggcgg cgagcagcag tgctcgcaag ttgccacccc agcggtatgc cagcactgtc
1645081 gtgacgaagc ccatcgccag cagcgagggt agcttcactt gcgacgacag cgtgatcagg
1645141 atggaacccg ccagcagcat ggccaggggc ccccattccg gacggggttt gactgcccgg
1645201 ctcgcgcccg cacgcgggga tgcccccagc tcgggccgcc ggctggcccg tattgtggcg
1645261 gggcccaacc gccaggtttc gggcgacggg cgtggggtat tcgccatatc aaggccgcgc
1645321 agcgcgaatt cgacgccggt cagcatcagc ccgagcatca gcgcttcgtt gtggatgccg
1645381 gcgaccaaat gcatgatcag cagcggattg gccgcgccta gccacagcgc gctgacctcg
1645441 gcgacgccac agcgctgagc tagccgaggg gtcgcccaca cgatcagggt cacaccgatc
1645501 aacaccacaa gccggtggca gagcacggca gcgacgatgt tttccccagt cagcgacgag
1645561 attccgcggc cgatccacaa gaacagcgga ccatatggcg ccggtgtctc ccgccacagg
1645621 ctgggcaccg acagggtgaa cacgtggccg aggcccaagc cggacgccgg acccacccgg
1645681 taagggtcga gtccgtccct gccgatctca ctttgggcta gatatgagta gacatccttg
1645741 ctgtacatcg gtggtgcgat caatagcggc agcatccaga gcagcagggt gcggtccagt
1645801 ttgccgcgcg acatccgccg cctgcccagc gtgaaccggc cgagcatcag ccaggccagc
1645861 gccatcatga ccgccccggt cgtggtcatg gtcaacgaca ccgtttggat tcgtgacggc
1645921 agattgagca gccggacccc gaaggtgggg tcctggacga cgggtcgggc cccggcgccc
1645981 agggcgccga tggccatcag gacggtgccg gtggccccaa acaggcgggt gcgcgccagc
1646041 gcggtgagct cggtagtggt cagcggtgca cccaccgcct gctcgtcgcc atgcaggctg
1646101 gcgatcgacc agctcagcgt atggtggcgg gctgccattg gtgcagccta acggcatgcc
1646161 cgggaattgc ttaggcgatc tcaatgtgac cagcacaacc ctgccgcata gggcatccct
1646221 ggtagaccga tcaacggaat tttgtcacac tgatgttgtg aaaatcccgg cggtctctac
1646281 cactgtcccc gcggcagtct cggacggtca cactcgtcgg gccattgtgc gcttgctgct
1646341 ggaatccgga tcgatcaccg ccggcgagat cggtgaccgg ctgggcctgt cggccgccgg
1646401 tgtgcggcgt catctggacg cgctgatcga ggcgggtgac gcggaagcgt cggcggccgc
1646461 gccgtggcag caggtgggac gcgggcggcc cgccaagcgc taccggctga ccgcggccgg
1646521 ccgggccaag ctcgaccact cctatgacga cctggcgtcg gcggccatgc ggcagctgcg
1646581 ggagatcggc ggcgaggagg cggtgcggac gtttgcccgg cgccgtatcg acgccatcct
1646641 ggccgacgtc gcgccggccg acggtcccga cgacgccgcg ctcgaggcgg ccgccgagcg
1646701 gatcgcaacg gcgctcagca aagccggcta cgtcgccacc accacgcggg tgggcgggcc
1646761 gattcacggt gtgcaaatct gccagcacca ttgcccggta tcccatgtcg ccgaggaatt
1646821 ccccgaattg tgcgaaaccg agcagcaggc catggccgag gtgctcggca cccacgtcca
1646881 gcggttggcg accatcgtca acggagactg cgcctgcacc acccacgtac ccctgtcgcc
1646941 ggcgcccagc ccgcgcccac ccgccaccag caccgaagga gcgtcccgat gacactcacc
1647001 ccagaggcca gcaagagcgt tgcccagccc ccgacccagg ctcccctgac ccaggaagag
1647061 gcgatcgcgt cgctgggccg gtacggctac ggctgggcgg actccgacgt cgcgggtgcc
1647121 aacgcgcagc gcgggctttc cgaggcggtg gtccgcgaca tctccgcgaa gaagaacgag
1647181 cccgattgga tgctgcagtc gcggctgaag gcgctgcgca ttttcgaccg caagcccatt
1647241 ccgaagtggg gctccaacct cgatggcatc gatttcgaca acatcaagta cttcgtgcgc
1647301 tccaccgaga agcaggccgc gagctgggat gatttgccag aggacatccg caacacctac
1647361 gaccggttgg gaatcccgga ggccgagaag cagagattag tagctggagt agccgcacaa
1647421 tacgaaagtg aagttgtata tcaccagatc agagaggatc tggaggctca aggagtcata
1647481 tttttagaca ctgatactgg tttgcgagaa cacccggata ttttcaagga atatttcggt
1647541 acagtaatcc ctgccggcga taataagttt tctgcattga atactgcagt ttggagtggt
1647601 gggtccttta tttacgtccc gcccggtgtt cacgtcgaca ttccgctgca ggcctacttc
1647661 cgaatcaaca ccgagaacat gggccagttc gagcggacgc tgatcatcgc cgatgagggc
1647721 tcttacgtgc actacgtaga gggctgcctg cccgccggcg agctcatcac gaccgccgac
1647781 ggcgatttgc ggcccatcga gtcgattcgc gtcggtgact tcgtcaccgg ccacgacggg
1647841 cggccacacc gcgtcaccgc tgtacaggtg cgtgacctcg atggcgagct gttcaccttc
1647901 acaccgatgt cgcctgccaa cgcattctct gtcaccgccg agcaccccct tctcgctatt
1647961 ccccgcgacg aggtgcgtgt tatgcggaag gaacgcaatg ggtggaaggc tgaagtcaac
1648021 agcaccaagc tgcgtagcgc cgagccgcga tggatcgcgg cgaaggatgt ggccgagggt
1648081 gacttcctga tctaccccaa gccgaagccg atcccccaca ggacggtttt gccgctcgag
1648141 tttgcgcgcc tggcgggcta ctacctggcg gagggtcacg cgtgtctcac caatggctgt
1648201 gagtcgctga tcttctcgtt ccacagcgat gagttcgagt acgtcgagga tgtgcgccaa
1648261 gcgtgcaagt cgctgtacga gaagtcggga tcggtattga tcgaggagca caagcattcg
1648321 gcgcgcgtca ccgtgtacac gaaggcgggc tatgcggcga tgcgcgacaa cgtcggcatt
1648381 ggatcgtcga ataagaagct gtcggatctg ttgatgcgtc aagacgagac gttcttgcgt
1648441 gagctggtcg acgcctatgt gaatggagac ggcaacgtca cgcgccgtaa cggggcggtg
1648501 tggaagcggg tacatacgac atcgcgcctc tgggcgttcc agttgcagtc catcctggcg
1648561 cgtctgggtc actacgccac tgttgaactg cgccgaccgg gcggccctgg tgtgatcatg
1648621 ggccgcaacg tcgttcgcaa ggacatctac caggtgcagt ggaccgaggg cggccgcgga
1648681 ccgaagcagg cccgcgactg cggcgactac tttgcggtgc caatcaagaa gcgagcggtc
1648741 cgcgaagcac atgagcccgt ctacaacctc gatgtcgaga atccggacag ctacctcgcc
1648801 tacgggttcg ccgtgcacaa ctgcaccgca ccgatctaca aatcggattc attgcactca
1648861 gcggtggtcg agatcatcgt gaaaccccat gcgcgcgtgc gttacaccac catccagaac
1648921 tggtcgaaca acgtctacaa cctggtcacc aagcgggccc gcgccgaagc cggggccacc
1648981 atggagtgga tcgacggcaa catcgggtcc aaggtgacca tgaagtaccc ggcggtctgg
1649041 atgaccggcg agcacgccaa gggcgaagtg ctctcggtgg cgttcgccgg cgaagaccag
1649101 caccaggaca ccggcgccaa gatgctgcac ctggcgccga acacgtcgag caacatcgtg
1649161 tccaagtcgg tggcccgcgg cggcggccgc acctcctacc gtggcctggt gcaggtcaac
1649221 aagggggcgc atgggtcgcg gtccagcgtg aaatgcgatg cgctgctggt ggatacggtc
1649281 agccgcagcg acacctaccc ctacgtcgac atccgcgagg acgacgtcac catgggccac
1649341 gaggccaccg tgtccaaggt cagcgagaac cagctgttct acctgatgag ccgcgggctg
1649401 accgaggacg aggcgatggc gatggtggtg cgcggcttcg tcgagccgat cgccaaggag
1649461 ctgccgatgg agtacgcgct ggagctcaac cggctgatcg agctgcagat ggagggcgcg
1649521 gtcggatgac ggctccggga ctgacagcag ccgtcgaggg gatcgcacac aacaagggcg
1649581 agctgttcgc ctcctttgac gtggacgcgt tcgaggttcc gcacggccgc gacgagatct
1649641 ggcggttcac cccgttgcgg cggctgcgtg gcctgcacga cggctccgcg cgggccaccg
1649701 gtagcgccac gatcacggtc agcgagcggc cgggcgtata cacccagacc gtgcgccgcg
1649761 gcgatccacg actgggcgag ggcggcgtac ccaccgaccg cgttgccgcc caagcgtttt
1649821 cgtcgttcaa ctccgcgact ctggtcaccg tcgagcgcga cacccaggtc gtcgagccgg
1649881 taggcatcac cgtgaccggg ccgggggagg gcgcggtggc ctatgggcac ctgcaggtgc
1649941 gtatcgagga gcttggcgag gcggtcgtgg tcatcgacca ccggggcggc ggaacctacg
1650001 ccgacaacgt cgagttcgtt gtcgacgacg ccgctcggct gaccgccgtg tggatcgccg
1650061 actgggccga caacaccgtt cacctcagcg cgcaccatgc tcggatcggc aaggacgcgg
1650121 tgctgcgcca cgtcaccgtc atgttgggcg gcgacgtggt gcgaatgtcg gcgggcgtgc
1650181 ggttctgcgg tgcgggtggg gacgcggaac tgctggggct gtatttcgcc gacgacggcc
1650241 agcacctgga gtcgcggctg ctggtggacc acgcccaccc cgactgcaag tcgaacgtgc
1650301 tgtataaggg tgcactgcaa ggtgatccgg cgtcgtcgtt gcccgacgca cacacggtct
1650361 gggtgggtga cgtgctgatc cgtgcgcagg ccaccggcac cgacaccttc gaggtgaacc
1650421 ggaacctggt gctcaccgac ggcgcgcgtg ccgactcggt gcccaacctg gagatcgaga
1650481 ccggcgagat cgtcggcgcc ggacacgcca gcgccaccgg tcgcttcgac gatgagcaat
1650541 tgttctacct gcgttcgcgc ggtattcccg aagcacaggc ccgccggctg gtggtccgcg
1650601 gcttcttcgg tgagatcatc gccaagatcg cggtgcccga ggtacgcgag cgcctgaccg
1650661 cagccatcga acacgagctg gaaatcacgg aatcaacgga aaagacaaca gtctcatgac
1650721 cattttggaa attaaggacc tgcacgtcag cgtggagaac cccgcggagg cggaccacga
1650781 gatcccgatc ctgcgcggcg tcgacctcac cgtgaaatcc ggtgagacac atgccttgat
1650841 gggacccaac ggctcgggca agtcgacgct gtcctacgcc atcgcgggcc atcccaaata
1650901 ccacgtgacg tcgggcacca ttaccctcga cggcgcggac gtgctggcga tgagcatcga
1650961 cgaacgtgcg cgggccggcc tgtttctggc catgcaatat cccgtcgagg tgcccggtgt
1651021 ctcgatgtcg aacttcctgc gctcggcggc aaccgccatt cgcggcgagc cgccgaaact
1651081 gcggcactgg gtcaaagagg tcaaggccgc gatggccgcg ctcgacatcg acccggcctt
1651141 cgccgagcgc agcgtcaacg agggtttctc cggtggcgag aagaagcgcc acgagatcct
1651201 gcagctagaa ctgctcaagc ccaagatcgc catcctggac gagaccgact ccggcctgga
1651261 cgtcgacgcg ctgcgcgtgg tcagcgaggg ggtgaaccgc tacgccgaat cccagcacgg
1651321 cggcatcctg ctgatcacgc actacacccg catcctgcgc tacatccacc cggaatacgt
1651381 gcacgtgttc gtcggcggcc gcatcgtcga gtccggtggt tcggagctcg ccgacgaact
1651441 cgaccagaac ggctacgtgc gtttctcccc cgcaagcggg cggtaccccc accaacccgc
1651501 gccaaccgga gcctgacatg acggcctcgg tgaactcgct cgatctggcg gcgattcgcg
1651561 ccgatttccc catcctcaag cgcatcatgc ggggtggaaa cccgttggcg tatttggact
1651621 ccggcgccac ctcacaacgc ccgctgcagg tcctcgacgc cgagcgcgag ttcctgaccg
1651681 cgtccaacgg cgcggtccat cgtggcgcgc accagctgat ggaggaggcg accgacgcct
1651741 acgagcaggg ccgcgcggac atcgcgttat tcgtcggcgc cgacacggac gagctggtgt
1651801 tcaccaaaaa tgccaccgag gcgctcaacc tggtgtcata tgtgctgggg gacagccgtt
1651861 tcgagcgtgc cgtcggcccc ggcgacgtga tcgtcaccac cgagctggag catcacgcca
1651921 acctgatccc gtggcaggag ctggcccggc gcaccggggc cacattgcgc tggtacgggg
1651981 tgactgacga cgggcgcatc gacctggact cgctgtatct ggacgaccgt gtcaaagtcg
1652041 ttgcgttcac ccatcattcc aatgtgaccg gggtgctgac accggtgagc gagctggtct
1652101 cccgcgccca ccagtcgggt gcgctgaccg tgctggacgc ctgccagtcg gtgccgcacc
1652161 agccggttga cctgcacgaa ctcggcgtcg acttcgccgc gttttccgga cataaaatgc
1652221 tgggccccaa cggaatcggt gtgctgtacg gccgccgtga gctgctagcg cagatgcccc
1652281 catttctcac cggcggttcg atgatcgaaa cggtgaccat ggaaggcgcc acctacgcgc
1652341 cggcgccgca acggttcgag gccggtaccc cgatgacctc ccaggtggtc gggttggccg
1652401 ccgcggcccg ctatctcggc gcgatcggca tggccgcggt ggaggcccac gagcgggagc
1652461 tggtagccgc ggccatcgaa ggcctgtccg gcatcgacgg tgtgcggatc cttggcccga
1652521 cgtcgatgcg ggaccgaggg tcgccggtgg cgttcgtcgt cgagggcgtg cacgcgcacg
1652581 acgtgggtca ggtactcgac gacggcggcg tggcggtgcg ggtcgggcac cactgcgcgc
1652641 tgccgctgca ccgcaggttc ggtctggccg ccaccgcgcg ggcgtcgttc gcggtgtaca
1652701 acaccgcaga cgaggtggac cgcttggtgg ccggcgtgcg gcgatcccgg catttctttg
1652761 gaagagcgtg acgttgcgtc tggagcagat ctatcaggac gtgatcctcg atcactacaa
1652821 gcatccgcag catcgggggc tgcgggagcc gttcggcgcc caggtgtatc acgtgaaccc
1652881 gatctgcggc gacgaggtca cgctgcgggt cgcgttgtcc gaggacggca ccagggtcac
1652941 cgacgtttcc tatgacggac aaggctgttc gatcagccag gccgcgacct cggtgctcac
1653001 cgaacaggta atcggacaac gcgtgccgcg ggcgctgaac atcgtcgacg ccttcaccga
1653061 aatggtgtcc tcccgcggga ccgtgccagg cgacgaggac gtcttaggcg atggggtcgc
1653121 gttcgccggg gtggccaaat acccggcccg ggtgaaatgc gcgctgctcg gatggatggc
1653181 gttcaaagat gcgctggccc aagccagcga agccttcgag gaggttacag atgagcgaaa
1653241 ccagcgcacc ggctgaggaa ttgctcgccg acgtcgagga ggcgatgcgc gacgtcgtcg
1653301 acccggagct ggggatcaac gtcgttgacc tgggcctggt ctacggcttg gacgtgcaag
1653361 acggtgacga agggaccgtc gcgctgatcg acatgaccct cacgtcggcg gcgtgcccgc
1653421 tgaccgatgt catcgaggat cagtcgcgca gcgcgctggt cggcagtggc ctggtcgacg
1653481 acatccgcat caactgggtg tggaacccgc cgtggggccc ggacaagatc accgaagacg
1653541 gccgcgaaca attgcgggcg ctcggcttca ccgtctgaac cggcgcgtcg ccgaacgtga
1653601 actgagggcg gagaatccgg caaaataccg ccgtgagttc acgttcggcg ggcggtgcga
1653661 gcgaaacccg cctcagaagg cgtcttcggg cacgcgcatg atgtcgtcgt cgatgttttc
1653721 gatgacactg cgcaccccgg tcagtttcgg cagcatgttc ttcgcaaaga acgccgcgac
1653781 cgcgatcttg ccccgataga acgcttcatc gttctgcgat ggcccgtcgg ccagtgcggc
1653841 gtgtgcgacc ccggccagca cgagcagccg ccagccgatg agcaagtcgc ccacggcgag
1653901 caaatagcgc acggatccga gccccacctt gtagatgtcg ctggagtgct gcgcggcgga
1653961 catcaggtac ccggtcagcg cgcccgtcat tgccgtgatg tcgtcgagcg cggtgcgcag
1654021 cagctcggct tgcggtttta gcgacgggtc aatgttctcg acggtgtggg tgacctgagc
1654081 cagcacaaat tgcaaagcct tgccgtgatc gcgcacgatc ttgcggaaga agaagtccag
1654141 tgcctggatc gccgtggtgc cctcgtagag ggaatcgatc ttggcgtcac ggatgtactg
1654201 ctcgagggga tagtcgacca gaaagcccga gccgcccagc gtctgcagcg actcggtgag
1654261 gatttcgtag gcgcgttctg aacccacgcc cttgacgatg ggcagcagca gatcgtccac
1654321 gcggtgcgcc atgtcgtgat cggcacccga aacccgttgg gccacagcgt cgtcctggtg
1654381 agcagcggca tacaggtaca gcgcccgcag gccttcggca taggcctttt gggtcatcag
1654441 gctgcgccgc acgtcggggt ggtgcatgat tgtgacccgc ggcgccgtct tatccgtcat
1654501 ctgggtcaga tccgcgccct gcacccgctc cttggcgaag gcgagtgcgt tgagatagcc
1654561 cgtcgacaat gtgccggcgg acttaactcc gatggtcatg cgagcatgct caatcaccgt
1654621 gaacatctgc gcaatcccgt tgtgcacgcc gccgaccaga tagccaacgg cgggcacgtc
1654681 ggcaccgccg aacgtcaatt cgcatgtcgg agaggacttt aagcccatct tgtgttccag
1654741 gccggtcacg tagacgccgt tgcgggcgcc gagctcgaac gtatcggggt cgaagaggta
1654801 gttgggaacg tagaacaggc tcaacccctt ggtgcctggg ccggcgccct caggtcgggc
1654861 caacaccaaa tggaagatgt tctccgcggt attgccgaca tccccaccgg agatgaaccg
1654921 cttgacgccc tcgatgtgcc aggtgccgtc gggttgttcg aacgctttgg ttcgacccgc
1654981 gccgacatcg gaaccggcgt cgggctcggt gagcaccatg gtggcctgcc agccgcgctg
1655041 cacgccctcg gccgcccacc tgcgttgctc atcattgccc tcgatgtaaa gggactgggc
1655101 cagcaccggg cccaggttga aaaagcacgc cgacgggttg gcgcagtaga tcatttcgtt
1655161 gacggcccat gccagcggcg gcggcgctgg catgccaccg atctcctcgg ccaggcccag
1655221 ccgccaccag ccggcctcct tgattgcctg cactgtcttg gccaactcgt cgggcacgct
1655281 gatggagtgg gtgttcgggt cgaagaccgg tgggttgcgg tcggcgtagc cgaaggattc
1655341 ggcgatcgga ccctcggcca gccgcgccgc ttcggccaag atggtgcgga ccgtgtcgac
1655401 gtccagatcg ctgtagcgtc cggtgcccag gaccgcgccg atatcaagga cttcgagcag
1655461 gttgaactcg agatcgcgga cattggcgat gtagtgtccc aatgcggttc ccttcaggtg
1655521 gctgatcggc cctgatcggg cccagtctct ccgagcggga agaacgtacg caaccgtaac
1655581 ctgcggtggg agggcggaac tgcggcgact atgttccgtt cgcgccgggc aggccgagca
1655641 gcagcccgcc cctgccgccg agcccggggg cgccggcccc gccgccgtcg ccgccgtcac
1655701 cgccgttacc gatcagctgg gcgttgccac cgttgccgcc gttgccgccc aacgcgccgc
1655761 catcgccgcc ttccccgccg ttgccgaaca acccggcctg gccgccggcc ccgccgtggg
1655821 cgctcgatgc ccccccggct ccgctgccgc cggcgccgcc gttgccatag aagaacccgg
1655881 catcgccgcc acgcccagcg ctacccgcgg atagggctgc cccgccggca ccaccgtcgc
1655941 cgaacaggaa ggccctgccg ccggcgccac ctccgccgag gaagctgctg gcgccagcac
1656001 cgccgttgcc aaaaaacagc ccgccgttgc ctccagagcc accggctccc atgccgttgg
1656061 ggctgatgcc acccgcgccg ccggccccga agagcacggc ggagccgccg atgccgccgg
1656121 caccgccgcc accgccgcta ttgccgccgg ccccgccgtt gccgaacagc cacccgccgg
1656181 tgccgccggc gccgccgttg gcgcccaggg cgcccacgcc gccgttgccg ccgtggccca
1656241 gcagtccggc ggcgccgccg ttgccgccgg ggccggcagc gggcgagaag ccgttgccgc
1656301 cattgccgat caggagtccg ccggcctggc cgttggggtt cgccgcggtc ccatcggcgc
1656361 cgttgccgat cagcggacgg ttcaacagcg ccagggtggg cgcgttgatg acgtcgaata
1656421 gcggctgcaa ggggccaaag ttggtggcct ccgcggcggc gtacgcctgc gcgccgccgg
1656481 acagggcttg cacgaactgg ctgtgaaacg ccgcggcttg ggcgctgagc acctgatagg
1656541 tctggccgtg cgcgccgaac aacgccgcga ccgccgccga cacctcatcg gcgcctgcgg
1656601 ccgcgacagc ggtcgtctgg gccgccgcgg ccgagttggc cgcgctaatc atcgaaccga
1656661 ggcgcgcgag attccccgcc gctcccgaca cgaactccgt attcgcgacc acgaacgaca
1656721 tctggcacct ccgcaatgaa gagctagcga ccgacgtatc ttatcgcgat ccagcggccg
1656781 cttcacccgt ttcggggtaa cgcaccccgc cagaatggtt aatccgttag tggccccgct
1656841 tgccttgtgc cagtgaccaa ttcaatcgca taccgcaatg caatcgagat ttttggtcgt
1656901 tcctgcgtcc ctacactcgg ttcatcctga cgaattcgca cccctgtcgt gaggccgccg
1656961 gaatgacctt gaccgcttgt gaagtaactg ccgcggaggc tcctttcgac cgcgtttcaa
1657021 agaccattcc ccacccattg agctggggag ccgcgctgtg gtcggtagtc tccgtgcgct
1657081 gggccaccgt ggcgctgctg ctgtttctcg ccggactagt ggcgcaactg aacggtgctc
1657141 ccgaggccat gtggtggacg ctttacctgg cctgttatct ggccggcggc tggggctcgg
1657201 catgggcggg cgcacaagcg ttgcggaaca aggcacttga tgtggatctg ctgatgattg
1657261 ccgcggcggt cggagcggtc gcgattgggc agatcttcga cggcgcgctg ctgatcgtga
1657321 tcttcgccac gtccggtgcg ctggatgaca ttgccaccag acacaccgcg gaatcggtca
1657381 aaggcctgct ggacctcgcg ccggatcagg cggtggtggt ccagggcgac ggcagcgaac
1657441 gggtggtggc ggccagcgag ctggtggtgg gggaccgggt ggtggtgcgg ccgggggacc
1657501 ggatacccgc agacggtgcg gtgctgtcgg gggctagcga cgtcgaccaa cgctcgatca
1657561 ccggtgaatc gatgccggtg gccaaggccc gcggtgacga ggtgttcgcc ggcaccgtga
1657621 acggatcggg tgtattgcat ctggtggtca cccgtgaccc gagccagacc gtggtagccc
1657681 gcatcgtcga actggtcgcc gacgcttcgg cgacgaaggc caaaacccaa ctgttcattg
1657741 agaaaatcga gcaacgctac tccctgggca tggtcgcggc cacccttgcc ctcatcgtta
1657801 ttccgctgat gttcggcgcc gacctgcggc cggtgctgct gcgcgccatg accttcatga
1657861 tcgtggcatc gccatgcgcg gtggtgctgg ccaccatgcc gccgctgctt tcggcgatcg
1657921 ccaacgcagg ccgtcatggg gtgctggtca aatccgcggt ggtcgtcgaa cgcctggccg
1657981 ataccagcat cgtcgctttg gacaagaccg gtacgctgac ccgtggcatc ccgcgactgg
1658041 cttccgtcgc accgctggac cccaacgtgg tcgatgcccg gcgattgttg caattggcag
1658101 ctgccgcaga acaatccagc gagcacccgc ttggccgggc gatcgtcgcg gaagctcgtc
1658161 ggcgtggtat cgccataccg cccgccaagg acttccgcgc ggtcccgggc tgcggggtcc
1658221 acgccctggt gggcaacgat ttcgtcgaga tcgccagccc gcaaagctac cgcggtgcac
1658281 cgctagcaga gctggcgccg ctcctttctg ccggcgccac tgccgccatc gtcttgttgg
1658341 atggagttgc catcggtgtg ctcgggctca ccgatcagct tcgtccggat gccgtggagt
1658401 ccgtcgcggc gatggctgca ttgaccgccg caccaccggt gctgctcacg ggtgacaacg
1658461 ggcgagcggc ttggcgggtc gctcggaacg ccgggatcac cgatgtgcga gccgcattgc
1658521 tgcccgagca gaaggttgaa gtcgtgcgca acctgcaggc cggtggtcac caggtgctgc
1658581 tcgtcggcga cggcgtcaac gacgctcccg ccatggccgc cgcccgcgcc gctgtcgcca
1658641 tgggcgccgg cgccgatctg accctacaga ccgcagacgg ggtgaccata cgggacgaac
1658701 tgcacaccat cccgacgatc atcgggttgg cacggcaggc gcgccgggtg gtcaccgtca
1658761 acctggccat cgcggccacc ttcatcgccg tcctggtgct gtgggacctt tttgggcagc
1658821 tgccgctgcc actgggtgtg gtgggtcacg aagggtccac tgtgctggtg gccctcaacg
1658881 gcatgcggct attgaccaac cggtcgtggc gggccgcggc ttcggctgcg cgttaggctc
1658941 gatgtcgcag aactgaccag ggctgcgtta ggggtgcccg tgaccactcg agacctcacg
1659001 gcggcgtatt tccaacagac catctccgcc aacagcaacg tgcttgtgta cttttgggca
1659061 ccgctgtgcg ccccgtgcga cctgttcaca ccgacctacg aggcgtcgtc gcggaaacac
1659121 tttgacgtcg tgcatggcaa agtcaacatc gaaaccgaga aagatctggc ctcgatcgcc
1659181 ggggtcaagt tgttgcccac gctgatggcc ttcaagaaag gcaagctggt cttcaaacaa
1659241 gccggcatcg ccaatcccgc gatcatggac aatctggtgc aacaactccg ggcatacacc
1659301 ttcaagtccc cggccggcga aggtatcggc cctggaacaa agacttcatc ctgaggcgtt
1659361 gaggcaggcg tgactacccg agacctcact gccgcacagt tcaacgaaac catccaaagc
1659421 agcgacatgg tgctcgtcga ttattgggcc tcctggtgcg gcccgtgccg cgcgttcgcg
1659481 ccgacctttg ccgagtcgtc ggaaaaacac cccgacgtgg tgcacgccaa ggtcgacacc
1659541 gaagccgaac gagagcttgc agcggccgct cagatccgat ccatccccac gatcatggcc
1659601 ttcaagaacg gcaagttgtt gttcaaccag gccggcgcgc tgccgccggc agcattggag
1659661 agcctggtgc agcagctcaa ggcctacgag gtggaggccg gcgaagccac cacccagaac
1659721 gggcgagccc aacaagcctg accgggcgcc aggcgcccgg ctgtgcccca ccgctgcgcg
1659781 gcgcaagtcg tcgccgggta ccgttcaacg gtgagtttgg tcctcgtcga acacccgcgg
1659841 cccgagatcg cgcagattac cctcaaccgg ccggagcgga tgaactccat ggcattcgat
1659901 gtcatggtgc cgctcaaaga ggccttagcg caggtcagct acgacaactc ggtgcgggtg
1659961 gtggtgctga ccggcgcggg tcgagggttt tctccgggtg cggatcacaa gtcggcgggg
1660021 gtggtgccgc acgtcgagaa cttgactcgg cccacctacg cgctgcgttc gatggagctc
1660081 ctcgatgacg tcatcttaat gctgcgacgg ctgcaccagc cggtgatcgc cgcggtcaac
1660141 ggccccgcca tcggtggtgg gctgtgcctg gcactggctg cagacattcg ggtggcctcg
1660201 agtagcgcct acttccgggc cgccggtatc aacaacgggc tgaccgccag cgaattgggg
1660261 ctgagctacc tgttgcccag ggccattgga tcctcacgtg cgttcgagat catgttgacc
1660321 ggtcgcgacg tcagcgccga ggaagccgag aggatcgggc tggtatcccg tcaggtaccc
1660381 gatgaacagc tgctagatgc ctgctacgcg atcgccgcac ggatggcggg attctcgcgg
1660441 ccgggaattg agttgaccaa acgtacgctg tggagtggac tggacgccgc cagtctggag
1660501 gcgcacatgc aggccgaggg cttggggcag ctcttcgtcc ggctgctcac cgccaacttc
1660561 gaagaagcgg ttgccgcacg ggccgagcag cgggcgccgg tgttcaccga tgacacgtaa
1660621 cagcgcccaa gacaaccgac gaccagggag cgaatgtgat cacagctacg gacctcgagg
1660681 tccgcgctgg cgcgcgcatc ctgctcgcac ccgacggccc cgacctgcgt gtgcagcccg
1660741 gcgatcgtat cgggctggtc ggacgtaacg gtgccggcaa gaccaccacg ctgcgcattc
1660801 tggcggggga ggtcgaaccc tatgccgggt cggttacccg tgccggcgaa atcggctacc
1660861 tgccacagga tcccaaagtt ggcgatctcg acgtgctggc ccgtgaccgg gtgctgtccg
1660921 cccgcggact ggacgtcctg ctcactgatc tggagaagca gcaggcgttg atggccgagg
1660981 tcgccgacga ggacgagcgt gaccgcgcca tccgccgtta cggtcagctc gaggagcgat
1661041 tcgtcgcgct gggcggctat ggcgccgaaa gcgaagccgg ccgcatctgc gccagcctag
1661101 gcttgcccga gcgggtgctg acccagcggc tgcgtaccct ttccggaggt cagcgccgcc
1661161 gggtggaact agcccgcatt ttgttcgccg cgtccgagag tggcgctgga aattccacca
1661221 ccttgttgct cgacgagccg actaaccacc tcgacgctga ttcgctgggc tggctgcggg
1661281 acttcctgcg cttgcatacg ggcgggctgg tggtcatcag ccacaacgtg gacctggtgg
1661341 ccgatgtcgt caataaagtg tggttcctgg atgccgtgcg cggccaggtc gatgtttaca
1661401 acatgggctg gcagcgctac gtcgacgctc gggccaccga cgagcaacgt cgcatccggg
1661461 aacgcgctaa cgccgaacgc aaggcggccg cgctgcgtgc acaggccgcc aagttgggcg
1661521 ccaaggccac caaagccgtt gcggcccaga acatgttgcg ccgcgccgat cggatgatgg
1661581 ccgcactcga cgaggagcga gtcgccgaca aggtggcccg gatcaagttc cccaccccgg
1661641 cggcgtgtgg acgcacaccg ctggtggcca acggtctggg caagacgtat ggctcgctgg
1661701 aagtcttcac cggtgtcgac ttggccatcg accgcggctc gcgggtggtc atactcggac
1661761 tcaacggtgc cggcaagacc acgctgctgc gattgctggc cggtgtcgag cagcccgaca
1661821 ccggagtgct ggaacccgga tacggtttac ggatcggcta tttcgcgcag gagcacgaca
1661881 cgctcgacaa cgatgccacc gtttgggaga acgtccggca cgcggcaccg gatgccggcg
1661941 aacaggacct gcgcggcctg ctgggtgcgt tcatgttcac cggtccgcag ctcgagcagc
1662001 cggccggcac gctctccggc ggtgagaaga cccggctcgc gctggccggc ttggtggcct
1662061 ccaccgcgaa tgtgctgctg ctcgatgaac cgaccaacaa tctcgatccg gcctcgcgcg
1662121 agcaggtgct cgacgcgctg cgcagctacc gaggtgcggt ggtgctggtg acgcatgatc
1662181 ccggggcggc cgcggcgctc ggtccccaac gggtggtgct gttgcccgac ggcaccgagg
1662241 actactggtc cgacgagtat cgagatctca tcgagctggc ctgacctaga tgcggctgcc
1662301 gcgtaacgat ttcggccaaa gcaccaccgg ggcggcggcg ggttcttagg ctaggtgcct
1662361 gggatcgacg gagggtaccg atgcggaagt caaagaagac gcgcgatcag ctgctgcgcg
1662421 agttgcgcaa cgcctacgag ggcggggcca gtatccgcaa cctggcggcc accaccggcc
1662481 ggtcgtacgg atctattcac agcatgctgc gcgagtcagg caccacgatg cgcggccgcg
1662541 gcggccccaa tcgccgttcc cggccgcgtt gatccgccga ttgtgaatct gacgacgcga
1662601 cagcggcgtg tcgcgtcgtc agattcacag tcagcgcatg tcaagaccga cgcaccgagt
1662661 tctccaccag gtcgaggacg gcggctagcc gctgcgggtc ttcgccggag gccagccggg
1662721 ccagcaatcc gtcgagcacc aggtccaggt agcaccgcaa aacgtcgcta ggcacatcgt
1662781 cacgcactcg gttagcctgc ttttgccggc gcagccgatc ggtggtcgcc gccgccaatt
1662841 ccgcggagcg ctccgcccag ccgcggctga agtcagggtc gttgcgcagc ttgcgtgcga
1662901 tctccaacct ggtggccagc cagtcgaact ggtcgggcgc ggcaagcatg tcgcgcatca
1662961 caccgatgag gccttcgcgg gatgctacag ccgccattcg ctcggtatcc tcgcgcgcca
1663021 gcgcgaaaaa cagcgcgtcc ttgtcgcgga agtggtgaaa gatcgcaccg cgcgacatcc
1663081 cgattgcctg ttccaggcgc cggaccgtgg ccttgtcata gccgtattcg gcaaagcaac
1663141 ggcgcgcacc gtcgaggatc tgacggcggc gagccgccag atggtcctcg ctgaccttgg
1663201 gcacgggcgc tcggtcagcc tgacttcagt atgttgcgca gcacgtactg caggatgccg
1663261 ccgttgcggt agtagtccgc ctcaccgggg gtgtcgatgc gcaccacggc gtcgaactcg
1663321 atcgtggcgc cgtcgccctt ggtggcctgg acgcacaccg tcttgggtgt cttgccgtcg
1663381 ttaagcacgt cgataccggt gatgtcgaag acctcggtac cgtcgagtcc caacgacgac
1663441 gctgactttc cttcggggaa ctgcagcggg atcacgccca tgccgatcag gttggaccgg
1663501 tggatccgct cgaatgactc ggcgatcacc gcccgcacgc ccagtagcaa tgtgcctttg
1663561 gccgcccagt cccgtgacga acccgacccg tactctttgc cgccgaacac aaccagcgga
1663621 atgtgttgcg ccgcatagtt ctgcgcggcg tcgtagatga acgcctgcgg accgcccggc
1663681 tgggtgaagt cgcgggtata accgccggac acgtcgtcta gcagttggtt acgcagccgg
1663741 atgttggcga aggtgccacg aatcatcacc tcgtggttgc cgcggcgaga accgaaggag
1663801 ttgtagtcct tgcggtcgac accgtgttcg tcgaggtagc gcgccgcggg agttccgggc
1663861 ttgatggcgc cggcggggga gatgtggtcg gtggtcaccg aatcaccgag cagcgccagc
1663921 acccgggcac cgctgatgtt gccgaccggt tcgggtttgg ctgtcatccc ctcgaaatac
1663981 ggcggcttgc gcacgtaggt cgaattcggg tcccactcaa aggtgttgcc gctcggggtt
1664041 ggcaggttgc gccagcggtc gtcgcccttg aacacgtcgg cgtagttgcg ggtgaacatc
1664101 tcctggttga tcgccgcggc gatggtgtcg gagacatcct gctgcgatgg ccagatatcg
1664161 cggagaaaaa cgttcttacc gtctttgtct tgaccgagcg gctgggtttg gaagtcgaag
1664221 tccatggtcc cggccagcgc gtaggcgatg accagcggcg gcgatgccag gtagttcatc
1664281 ttcacgtctg ggttgatacg gccctcgaag ttccggttgc cggacagtac cgcggtcacc
1664341 gaaaggtcgt tgtcgttaac cgcttttgag atttcctcgg gcagcggccc ggagttgccg
1664401 atgcaggtgg tgcagccgta gccgaccaga tagaagccga gcttctccag atacggccac
1664461 aggccggatc tgtcgtagta gtcgttgacc acttgcgagc ccggggcaat cgtggtcttc
1664521 acccacggct tcgaggtcag tcccttttcg acggcgttgc gggccagcag cgccgcgccc
1664581 agcattactt cggggttgga ggtgttggtg caggacgtga tcgcggcaat caccaccgcg
1664641 ccgtggtcga gcacgaattc gccgagttcg tccgacttca cccgcactgg gttgctcacc
1664701 cggccatcgg catgcgcggc agccgagtgc acggtttcgt cagtggcgac gtcgtcgttg
1664761 gcgaacgtca gctgccccgg gtcgctggcc gggaatgtct cctcgactac ctcgtccagc
1664821 ttcgagtgcg ggtcgtgggg ggaatccggg gaaccattgc cgacatagtg gtaaatctgc
1664881 tcgcggaatg ttgatttggc ttgcgccaac gcgattcggt cctgtggacg ctttggtccg
1664941 gcgatcgacg gcaccacgtc ggataggttg agttcgaggt attccgagaa ctccggctcg
1665001 tgcttgggat cgtgccacat gccctgcgcc ttggcgtagg cctcgaccag tgcgacctgc
1665061 tccggcgtgc gaccggtaaa ccgcagatac ttgatggttt cttcgtcgat cgggaaaatc
1665121 gctgcggtgg aaccgaattc gggactcatg ttgcccaggg tggcgcggtt ggccagcggc
1665181 acctcggcca cgccctcgcc gtagaactcg acgaatttgc cgacgacgcc gtgctggcgc
1665241 agcatctcgg tgacggtcaa caccacgtcg gtggcggtga ctcccggctg gatctcgccg
1665301 gtcaacctga aacccacgac ccgcgggatc agcatcgata ccggctgacc cagcatcgcg
1665361 gcctccgcct cgatgccgcc gacaccccac ccgagcacac ccaggccgtt gaccatggtg
1665421 gtgtgtgagt cggtgcccac gcaggtgtcg gggtaggcca ctccgtcgcg agtcatcacc
1665481 acgctggcca ggtactcgat attgacctgg tgcacgatgc cggtgcccgg cggcaccact
1665541 ttgaagtcgt cgaaagcgcc ttggccccag cgcaggaatt ggtaacgctc accgttgcgc
1665601 tggtattcga tttcgacgtt gcgctcgaat gcgtcggcgc ggccgaacaa atcggcgatc
1665661 accgagtggt cgatcaccaa gtctgcgggc gccagcgggt tgaccttgtc cgggttgccg
1665721 cccagatcgg cgatcgcctc gcgcatggtg gccaagtcga cgatgcacgg tacgccggtg
1665781 aagtcctgca tcaccacccg ggcgggcgtg tactggatct cgatgctggg ctcggcctta
1665841 gggtcccagt tggcgatggc ctcgatgtgg tccttggtga tgttgctgcc gtcctcgttg
1665901 cgcaacaggt tctcggcgag cactttgagg ctgtagggga gtttcgcggt attggggacg
1665961 gcgtcgagac gatagatctg gtaactcttt tcgccgacct tcagggtgtc gtgggctccg
1666021 aatgagttca cagatttgct agtcacatca actcccaggg atttggttcg cccgccgacg
1666081 ggccgtgtcg acggcgtggt gtcagcctag cagtacgctt gtcctgcttt gttgccgtgt
1666141 gggtgcgcgc cgaagtgcga gcagcgcgta acgtgccagt agcacgtcgg caggaaggat
1666201 gcgatgaccg ggccatattt tcctcagacg atcccgttcc tgcccagcta cattccgcaa
1666261 gacgtcgaca tgaccgcggt caaagcggag gtcgccgcac tcggtgtcag cgctccaccg
1666321 gcggccacgc cgggcctgct cgaggtggtc cagcacgctc gcgacgaggg catcgatctc
1666381 aagatcgtgc tgctcgacca caacccgccc aatgacacac cgctgcgtga catcgcgacc
1666441 gttgtcgggg ccgactactc ggatgccacc gtcttggtgc tcagcccgaa ctatgtcggc
1666501 agttacagca cgcaataccc ccgggtcacg ctcgaggccg gggaagacca ttccaagacc
1666561 ggcaatccgg tgcagtccgc gcagaacttt gtccatgagc tgagcacacc cgagtttccc
1666621 tggagcgcgc tgaccattgt tttgctgatc ggtgtgctgg cagcggctgt gggtgctcgg
1666681 ttgatgcaac tgcgcgggag gaggtcagca acgtcgactg acgccgcccc aggggcgggg
1666741 gacgatctca atcaaggcgt ctagccagcc acatctatct cttctcgtgt tgccgcgcta
1666801 accgggcggt tgtttgcggc aaacgcgcga ggtcaccgtt gggtcacatt agtcgcacgt
1666861 accgggggca gtttgtgact tacgtttcca tagcgtcaga tgtgacgtac ggtgcaaatg
1666921 atgcttgtgg tgtcgttggc gttgacctgc gctgtccctc cgagttgagc cctaggagat
1666981 ctgagtcgaa tgagacggaa tcgccgtggc tcgccagcgc gaccggccgc acggtttgtc
1667041 cgtccggcaa ttccgtcggc tttgagtgtg gccctgctgg tatgcacacc ggggctggct
1667101 accgccgatc cacagacgga caccatcgcc gcgctgattg ccgacgtcgc caaggccaac
1667161 cagcgcctgc aagacctgag cgacgaggtt caggccgaac aggaaagcgt taacaaggcg
1667221 atggtcgacg tggaaaccgc tcgggacaac gctgccgcgg ccgaagacga cctggaggtc
1667281 agccagcgcg cggttaagga cgccaacgcg gcgatcgccg cggctcagca ccggttcgac
1667341 accttcgcgg cggccaccta catgaacggt ccctcggtca gctacctcag cgcgagcagc
1667401 cccgacgaga tcattgccac tgtgaccgcc gccaagaccc ttagcgccag ttcccaagcg
1667461 gtgatggcca acctgcagcg ggcccggacc gagcgggtga acacggagtc ggcggcgcgg
1667521 ctagccaagc agaaggctga taaggccgcc gccgacgcaa aggccagcca ggatgccgcg
1667581 gtggcggcgc tcaccgagac ccggcggaag ttcgatgaac agcgcgagga ggtccaacgc
1667641 ctggccgccg agcgcgatgc ggctcaagcc cgactgcagg cggccaggtt ggttgcctgg
1667701 tcctcggagg gtggtcaggg tgcgccgccg ttccggatgt gggatcccgg atcgggccct
1667761 gccggtgggc gtgcatggga tggcttgtgg gaccccacgc tgcccatgat ccccagcgcc
1667821 aacatccccg gcgacccgat cgcggtagtg aaccaggtgt tggggatctc ggcaacgtca
1667881 gcgcaggtca ccgccaatat ggggcgcaag ttcctggagc agctgggcat cttgcagccc
1667941 accgataccg gcatcaccaa cgctccggcg ggctcggccc agggccggat tccgcgagtt
1668001 tatgggcgcc aggcttctga atacgtgatc cgccgcggca tgtcacagat cggggtgccc
1668061 tattcctggg gcggcggcaa tgccgcgggc ccgagcaagg gcatcgactc cggggccggc
1668121 accgtcggct tcgactgctc aggcctggtg ttgtactcgt ttgctggggt gggcatcaag
1668181 ctgccgcact actcgggttc gcagtacaac ctgggccgca agatcccgtc ctcgcagatg
1668241 cgccgcggcg acgtcatctt ctacggcccg aacggtagcc agcacgtgac gatctacctc
1668301 ggcaacggcc agatgctcga ggcgcccgac gtcggtttga aggtgcgggt tgcgcccgtg
1668361 cgcacggctg gcatgacccc gtatgtggtc cgatacatcg agtactagac gaggattcat
1668421 gcgccacacg cgttttcacc cgatcaaact ggcctggatc accgcggtgg ttgccggcct
1668481 gatggtcggt gtggcaacgc ccgccgatgc cgaacccgga caatgggatc ccacgctgcc
1668541 ggcattggtc agtgcggggg cgcccggaga tccgctggcg gtagccaacg cgtcgttgca
1668601 ggccaccgcc caggccaccc agaccacgct ggatttgggc aggcagttcc tcggtgggtt
1668661 gggaatcaac ctcggcggcc ctgctgccag cgctcccagc gccgccacaa ccggcgcgag
1668721 ccggattccg cgggccaacg cccgtcaggc cgtcgaatat gtgattcgcc gggccgggtc
1668781 gcagatgggg gtgccctatt cgtggggtgg tggctcgctt cagggcccca gcaagggcgt
1668841 ggactcgggg gccaacactg tcggcttcga ctgctcaggt ctggtgcggt atgccttcgc
1668901 cggggtcggc gtgctgatcc cgcggttctc cggtgatcag tacaacgccg gtcgccacgt
1668961 tccgcccgct gaggccaagc gcggcgacct gatcttttac ggcccaggcg gcggccagca
1669021 cgtcaccctg tatctgggca acggccaaat gctggaggca tccggaagcg ccggcaaagt
1669081 cacggtgagc ccggtgcgaa aggccggaat gacgccgttc gtgactagga tcatcgaata
1669141 ctgagccagg tgtgatttgc cgggcaccac cgcggcgtcg acggaatcca ggaggcctgg
1669201 aatagttgaa cgcgggcgcg tcgctgcccc gcgacgttgg tcatgtcggc agtcgtgtcc
1669261 gattgagctg tggaggattt tgatgacatc agcaggtggg ttccccgcgg gcgccggcgg
1669321 ttaccagacc ccgggtgggc attcagcttc gccagcccac gaggcgcccc ccggtggtgc
1669381 cgaggggctg gccgccgagg tgcacacgct ggagcgggcc atcttcgagg tcaagcggat
1669441 tatcgtcggc caggaccagc tggtggagcg gatgctcgtc ggcctgctgt ccaaggggca
1669501 tgtgctgctt gagggcgttc ccggcgtggc caagacgttg gcggtggaga ccttcgctcg
1669561 ggtggtcggc gggacatttt cgcgcatcca gttcaccccg gatctggtgc ccaccgacat
1669621 catcgggacg cgcatctacc ggcaaggcag ggaggaattc gacaccgaac tcggaccggt
1669681 ggtggccaac ttcctgctcg ccgacgagat caaccgggct ccggcgaagg tgcagtcggc
1669741 gttgctggaa gtcatgcagg agcgccatgt gtccatcggc ggtaggacct tcccgatgcc
1669801 cagcccgttc ctggtgatgg cgacgcagaa cccgatcgag cacgagggcg tctacccgct
1669861 accggaggcg caacgggacc gcttcctgtt caagatcaac gtgggctacc cgtcgcccga
1669921 agaagagcgc gaaatcatct accgtatggg tgttaccccg ccgcaggcca agcagatcct
1669981 gagcacgggc gacctgctgc ggctgcagga gatagcggcc aacaacttcg tccaccacgc
1670041 gctggtcgac tatgtcgttc gagtcgtctt cgccacccgc aaacccgagc agttggggat
1670101 gaacgacgtg aagagctggg tcgcgttcgg cgcatccccg cgtgcttcgc tgggcatcat
1670161 cgccgccgca cggtccctgg cgctggtccg gggccgtgac tatgtcatcc cgcaagacgt
1670221 catcgaggtc attcctgatg tgctgcgaca ccggctcgtg ctcacctatg acgcgctcgc
1670281 cgacgaaatc tcaccggaga tcgtcatcaa ccgtgtgctg cagactgtgg cgctgccaca
1670341 ggtgaatgcc gttccacagc aaggccattc ggtgccgccg gtgatgcagg ccgcggccgc
1670401 ggcgagcggc cggtgaccga atccaaagcg ccggcggtgg tgcatccgcc gtcgatgctg
1670461 cgcggggaca tcgacgaccc gaagctggcg gcggcgctgc gcaccctcga gttgaccgtc
1670521 aagcagaagc tcgacggtgt cttgcacggc gatcacctcg gcctgatacc tgggccgggt
1670581 tcggagccag gggagtcgcg cctctaccag cccggtgacg atgtccgccg gatggactgg
1670641 gcggtcaccg ctcgcaccac tcacccgcat gtccggcaga tgatcgccga ccgggaactg
1670701 gaaacctggc tggtggtcga catgtcggcc agcctggatt ttggcaccgc ctgctgcgag
1670761 aaacgtgacc tcgcggtggc ggcggcggct gccatcacct tcctcaacag cggcggcggc
1670821 aaccggctcg gtgcgctgat cgccaacggc gccgcgatga ctcgggtgcc ggctcgcacc
1670881 gggcgccaac atcagcacac gatgttgcgc accattgcga ccatgccgca ggcccctgcg
1670941 ggggtccgcg gcgacctggc ggttgccatc gatgcgctgc gccggcccga acgtcgtcgc
1671001 gggatggcgg tgatcatcag cgattttctg ggcccgatca actggatgcg tccgctgcgg
1671061 gcgatcgcag cccgccatga ggtgctggcc atcgaagtgc tcgatccgcg cgatgtcgaa
1671121 ttgccggacg tgggtgatgt ggtgctgcag gacgccgaat ccggggttgt gcgcgagttc
1671181 agcatcgacc ctgcgctgcg cgacgacttc gctagggcag ctgcggcgca ccgggccgac
1671241 gtggcgcgca ccatccgcgg ttgcggggca cccttgctat cgcttcgcac cgaccgcgac
1671301 tggcttgccg atatcgtacg attcgtcgcc tctcgccggc gtggggcatt ggcgggacac
1671361 cagtgatggg tcagttatga cattgccgtt gctggggccg atgacgctat ccggcttcgc
1671421 gcattcatgg ttcttcctat tcctgtttgt cgtggccgga ctggtcgcgc tgtacatcct
1671481 gatgcagctg gcgcgccagc ggcgaatgct gcggttcgcc aacatggagt tgctggagag
1671541 cgtcgcaccc aagcggccat cccgctggcg gcatgtcccg gcgatcctgc tggtgttatc
1671601 gctgctgctg ttcaccatcg cgatggccgg tccgacgcat gacgtccgga ttccccgcaa
1671661 ccgcgcggtg gtgatgttgg tgatcgacgt gtcgcagtcg atgcgcgcca ccgacgtcga
1671721 gcccagccgg atggtggccg cgcaggaggc tgccaagcag ttcgccgacg agttgacccc
1671781 gggcatcaat ctgggattga ttgcctacgc gggcacggcg acggtcctgg tgtcgccgac
1671841 gaccaaccgg gaggcgacca agaatgcgct ggacaagtta cagttcgccg accgtaccgc
1671901 caccggggag gcgatcttca ccgcgctgca ggccatcgcc acggttggcg cggtgatcgg
1671961 tggcggcgac acgccgccgc cggcgcgcat cgtgctgttc tccgacggca aggagacgat
1672021 gccgaccaac ccggacaacc ccaagggcgc ctacaccgcc gcccgcaccg ccaaggacca
1672081 gggcgtgccg atttcgacga tctcgttcgg caccccatac ggcttcgtcg agatcaacga
1672141 ccagcgccaa ccggtgcccg tcgacgacga aacgatgaag aaggtcgccc agctctccgg
1672201 tggaaattcc tacaatgcgg cgactttggc cgagctgagg gccgtttact cgtcgctgca
1672261 gcagcagatc ggctacgaga ccatcaaggg tgacgccagc gtcggctggt tgcggttggg
1672321 tgcgctggcg ctggcgttgg cggcgctagc ggcgctgctc atcaaccggc ggttgccgac
1672381 ttagcttctc ccgcggcccc ggcagcccgc gagcgtaacc tggctgcgat ttccggcgcg
1672441 gattttcgca gtgcggttac gctcggaaag cgcgggcctc gcccacgcgg cggatgatgt
1672501 cagcggggtg gtcctcggcg acgacccgga ccacgatcca cccgtagcgg tgctggactt
1672561 tctcgtgccg gaggatgtct ttccggtagt ggtagcgact ggtcagatgg tggtcgccgt
1672621 catactcggc cgcgaccttg atgtcttgcc agcccatatc caaatgggct tccgcccagc
1672681 cccattcgtt gcgcaccgcg atctgcgtct gggggcgcgg aaagccggcg cggatcaaca
1672741 acaagcgcag ccaggtttcc ttgggggact gggcaccgcc gtcgacgagg tccagagcgg
1672801 ctcttgcggc cttcatgcca cggcggcccc gatagcgctc gatcagcggc tcgacgtcgg
1672861 ccaccttcaa atcggtggcc tgtatcaggg cgtcgacggc cgcgacggcg gggtccaatg
1672921 gaaatcgact ggtcaggtcg agcgccgttc gctccggtgt ggtcacgcgc atgccctcga
1672981 tgacgcagat ctcgtcgggc tcgatgcgct cttcccagac ttgcagcccc ggggcacggc
1673041 ggcggttggt gtcgatgatc gcggcgggaa gatccgcgtc gatccacttg gcgccatgga
1673101 aggcagaagc cgagtagccg gccagcacgc cgcggcggcg cgagcgcagc cacagcgctt
1673161 ttgcacgcaa ttgcgcggtc agttccacac cctgcggcac gtacacgtct ttatgtagcg
1673221 cgacatacct gctgcgcaat tcgtagggcg tcaatacacc cgcagccagg gcctcgctgc
1673281 ccagaaaggg atccgtcatg gtcgaagtgt gctgagtcac accgacaaac gtcacgagcg
1673341 taaccccagt gcgaaagttc ccgccggaaa tcgcagccac gttacgctcg tggacatacc
1673401 gatttcggcc cggccgcggc gagacgatag gttgtcgggg tgactgccac agccactgaa
1673461 ggggccaaac ccccattcgt atcccgttca gtcctggtta ccggaggaaa ccgggggatc
1673521 gggctggcga tcgcacagcg gctggctgcc gacggccaca aggtggccgt cacccaccgt
1673581 ggatccggag cgccaaaggg gctgtttggc gtcgaatgtg acgtcaccga cagcgacgcc
1673641 gtcgatcgcg ccttcacggc ggtagaagag caccagggtc cggtcgaggt gctggtgtcc
1673701 aacgccggcc tatccgcgga cgcattcctc atgcggatga ccgaggaaaa gttcgagaag
1673761 gtcatcaacg ccaacctcac cggggcgttc cgggtggctc aacgggcatc gcgcagcatg
1673821 cagcgcaaca aattcggtcg aatgatattc ataggttcgg tctccggcag ctggggcatc
1673881 ggcaaccagg ccaactacgc agcctccaag gccggagtga ttggcatggc ccgctcgatc
1673941 gcccgcgagc tgtcgaaggc aaacgtgacc gcgaatgtgg tggccccggg ctacatcgac
1674001 accgatatga cccgcgcgct ggatgagcgg attcagcagg gggcgctgca atttatccca
1674061 gcgaagcggg tcggcacccc cgccgaggtc gccggggtgg tcagcttcct ggcttccgag
1674121 gatgcgagct atatctccgg tgcggtcatc ccggtcgacg gcggcatggg tatgggccac
1674181 tgacacaaca caaggacgca catgacagga ctgctggacg gcaaacggat tctggttagc
1674241 ggaatcatca ccgactcgtc gatcgcgttt cacatcgcac gggtagccca ggagcagggc
1674301 gcccagctgg tgctcaccgg gttcgaccgg ctgcggctga ttcagcgcat caccgaccgg
1674361 ctgccggcaa aggccccgct gctcgaactc gacgtgcaaa acgaggagca cctggccagc
1674421 ttggccggcc gggtgaccga ggcgatcggg gcgggcaaca agctcgacgg ggtggtgcat
1674481 tcgattgggt tcatgccgca gaccgggatg ggcatcaacc cgttcttcga cgcgccctac
1674541 gcggatgtgt ccaagggcat ccacatctcg gcgtattcgt atgcttcgat ggccaaggcg
1674601 ctgctgccga tcatgaaccc cggaggttcc atcgtcggca tggacttcga cccgagccgg
1674661 gcgatgccgg cctacaactg gatgacggtc gccaagagcg cgttggagtc ggtcaacagg
1674721 ttcgtggcgc gcgaggccgg caagtacggt gtgcgttcga atctcgttgc cgcaggccct
1674781 atccggacgc tggcgatgag tgcgatcgtc ggcggtgcgc tcggcgagga ggccggcgcc
1674841 cagatccagc tgctcgagga gggctgggat cagcgcgctc cgatcggctg gaacatgaag
1674901 gatgcgacgc cggtcgccaa gacggtgtgc gcgctgctgt ctgactggct gccggcgacc
1674961 acgggtgaca tcatctacgc cgacggcggc gcgcacaccc aattgctcta gaacgcatgc
1675021 aatttgatgc cgtcctgctg ctgtcgttcg gcggaccgga agggcccgag caggtgcggc
1675081 cgttcctgga gaacgttacc cggggccgcg gtgtgcctgc cgaacggttg gacgcggtgg
1675141 ccgagcacta cctgcatttc ggtggggtat caccgatcaa tggcattaat cgcacactga
1675201 tcgcggagct ggaggcgcag caagaactgc cggtgtactt cggtaaccgc aactgggagc
1675261 cgtatgtaga agatgccgtt acggccatgc gcgacaacgg tgtccggcgt gcagcggtct
1675321 ttgcgacatc tgcgtggagc ggttactcga gctgcacaca gtacgtggag gacatcgcgc
1675381 gggcccgccg cgcggccggg cgcgacgcgc ctgaactggt aaaactgcgg ccctacttcg
1675441 accatccgct gttcgtcgag atgttcgccg acgccatcac cgcggccgcc gcaaccgtgc
1675501 gcggtgatgc ccggctggtg ttcaccgcgc attcgatccc gacggccgcc gaccgccgct
1675561 gtggccccaa cctctacagc cgccaagtcg cctacgccac aaggctggtc gcggccgctg
1675621 ccggatactg cgactttgac ctggcctggc agtcgagatc gggcccgccg caggtgccct
1675681 ggctggagcc agacgttacc gaccagctca ccggtctggc tggggccggc atcaacgcgg
1675741 tgatcgtgtg tcccattgga ttcgtcgccg accatatcga ggtggtgtgg gatctcgacc
1675801 acgagttgcg attacaagcc gaggcagcgg gcatcgcgta cgcccgggcc agcaccccca
1675861 atgccgaccc gcggttcgct cgactagcca gaggtttgat cgacgaactc cgttacggcc
1675921 gtatacctgc gcgggtgagt ggccccgatc cggtgccggg ctgtctgtcc agcatcaacg
1675981 gccagccatg ccgtccgccg cactgcgtgg ctagcgtcag tccggccagg ccgagtgcag
1676041 gatcgccgtg accgcggaca tccgggccga gcgcaccacg gcggtcaacg gtctcaacgc
1676101 atcggtggca cgctgagcgt ccgacaacga ctgcgttccg atcggcaatc gactcagccc
1676161 ggcactgacc gcgatgatcg catcgacgtg cgcggcattc tcgagcaccc gcaatgcgcg
1676221 cgatggcgcg tggtcgggaa cccggtgttg ccgtgacgat tcgagcaact gctcgacgag
1676281 gccacggggc ttggcgacgt cgctagatcc cagtccgatg gtgctcaagg cttcggcggc
1676341 cgagcgcacc gctgaccgca acgcgtattc ggcatcgccg agctcgtagt gttccaacac
1676401 tggggccccg ggaagtgaat acaccatcca agaaagtgca cacaattcgg gcgtgagtgg
1676461 ctcgctctgc gcggcttcgt cgacatcgcc ataggagaac tccgggacca ggccaacggc
1676521 gctgccggga tcctccgggt tggcgacgat caccgcctcg ccggcggcaa gggcgtcgtg
1676581 ctcgaactgt gttcccgcag ccagcccgcg cacatcgccc ggcaccggca acaccacatt
1676641 gatcgtcccc cgcagtcggc gccggcccac cgcggcgcgc agtgtctgca ggagcgagac
1676701 cgttccagca tcgtggacgt cgggccacgg cagcccggtg tggcccgcag ccacggcatc
1676761 ataagctgcg acggattgcg ttggcgccca aagtgataat gcatccaaca cgtcgtcggg
1676821 agcagccttg ccggcgagcc aagcgttagc ccagatcgac agcgaaacac tgggacacca
1676881 catgatcttg cagtgtagtt gttcgacccg gctgacgcgg atcacgcgta tcctaagcgc
1676941 atgcccgtcg ctttgatctg gcttatcgcg gcgttggtgc tcgtcggcgc agaggcactg
1677001 accggcgaca tgttcttgct gatgctcggc ggcggtgcgc tggccgcctc ggtaagcagc
1677061 tggctgctgg cttggccgat gtgggccgac ggggcggtgt ttctcctcgt ctcggtgctg
1677121 ctgctggtgt tggttcggcc ggcggtgcgg cgccggctga cgcagaccaa aggtgtgcag
1677181 ctgggcatcg aggcgctgga gggtaagaag gcggtggtgc ttggtcgggt ggcccgcgac
1677241 gggggtcagg tgaagctgga cggccaggtg tggacggcgc gcccgctcaa cgacggtgat
1677301 gtgttcgaac ctggtgactc ggtgaccgtg gtgcaaatcg acggcgccac ggcggtggtc
1677361 ttcaaggacg tgtagggact cgagaaagga attccggtgc aaggagccgt tgctggtctg
1677421 gtgtttctgg ccgtcctggt gattttcgcc atcatcgtgg tggccaagtc ggtggcgctg
1677481 atcccgcagg cggaggccgc ggtgatcgag cggctgggtc gctatagtcg tacggtcagt
1677541 gggcagttga cgctgttggt gccgttcatc gaccgcgtcc gggctcgggt ggacctgcgc
1677601 gagcgggtgg tgtcgtttcc gccgcaaccg gtgatcaccg aggacaactt gacgctgaac
1677661 atcgacaccg tcgtctactt ccaggtgacc gttccgcagg cggcggtgta cgagatcagc
1677721 aattacatcg tcggggtcga acagctcacc accaccaccc tgcgcaacgt tgtcggcggg
1677781 atgacgctgg agcagacgtt gacctcgcgt gaccagatca acgcccagct gcgcggcgtt
1677841 ctcgatgagg cgaccggccg ctggggtctg cgggtggcgc gggtggagct gcgcagcatc
1677901 gatccgccgc cgtcgattca ggcgtcgatg gaaaagcaga tgaaggccga ccgggagaag
1677961 cgagcgatga ttctgaccgc cgaaggtacc cgggaggcgg cgataaaaca ggccgagggg
1678021 caaaagcagg cgcagatcct ggccgccgag ggcgccaagc aggccgcgat cttggctgct
1678081 gaggccgatc ggcagtctcg gatgctgcgc gctcagggtg agcgcgccgc ggcctacctg
1678141 caggcgcaag ggcaggccaa ggccatcgag aagacgttcg ccgcgatcaa ggctggccgg
1678201 cccaccccgg agatgctggc ctaccaatac ctgcagacgc tgccggagat ggcgcgtggg
1678261 gacgccaaca aggtatgggt ggtgcccagc gacttcaacg ccgcactgca ggggttcacc
1678321 aggctgctgg gcaagccggg tgaggacggg gtgttccggt tcgagccgtc cccggtcgaa
1678381 gaccagccca agcacgcggc cgacggtgac gacgccgagg tcgccggctg gttctccacc
1678441 gataccgacc cgtcgatcgc tcgggcggtg gctacagccg aggcgatagc ccgcaagccg
1678501 gtcgagggtt cgctggggac gccccccagg ttgactcaat agagtggtcc gatgagtggt
1678561 ttgacctcac cgaaaaccta tgcggtactg gcagctctgc aggcgggcga cgcggtggcg
1678621 tgcgccatcc cgctgccacc tatcgccagg ttactcgacg acttggacgt tccggtcagc
1678681 gttcgcccgg tgctgccggt ggtcaaggcc gcctctgcgg tcggtttgtt gtcggtcacc
1678741 cgattcccgg ccttggcgcg gctgacgaca gcgatgttga cgttgtactt catcctcgcc
1678801 gtgggggcac atgtccgggt gcgagatcgc gttgttaatg cgattccggc ggcgtcattc
1678861 ctgacgttgt tcgcgctgat gacggcaaag gggccggagc gcacttaagc atggaggcgc
1678921 aactcgacct atggcagtgg tgtgtcggtc ggtgaggtcg aggtgctcaa ggtcgaaaac
1678981 agccgggtgc gcgccgagca gctggccaaa ctgtacgaat tgcgctcaag tcgggatcgg
1679041 gtcagggtcg acgccgcact agccgagctg agccgcgccg cggccgcccg cggttgtgcc
1679101 ggtactagcg ggctcggcaa caacctgatg gcgccggggc cgccccattc cctcctggga
1679161 cgggatcgct gacgccacaa tcgacctgct acgaaggctg gccgagcggc tggggtacac
1679221 actggattgg cgagcgatcc gtggagccga acccgttgcc accgccattc tgcgtcggtt
1679281 agtctctttt tcgaccttgg ggcgcggagg gtcgttatgg tgtgtcacag tgctttgctg
1679341 tcaaaggcat tggcggtgcc gaccaagcga cactgggcag tgcagaaatc ctcgtgaaat
1679401 acgctcaact cgctgacaaa cgcgctcggg tatatgtcct ggtgtcgacc tggttggtcg
1679461 tgtggggtat ctggcatgtg tattttgtcg aagctgtctt tccgaatgcc atcctgtggt
1679521 tgcattatta cgcggccagc tatgaattcg ggtttgtacg tcgcgggctg ggcggtgaac
1679581 tgattcgcat gttgaccggc gatcatttct ttgccggcgc ctataccgtt ctgtggacgt
1679641 ctatcacggt gtggctgatc gcccttgccg tcgtggtgtg gcttatcctt tccacgggca
1679701 accggtccga gcgcaggata atgcttgccc tcctcgttcc ggtgctaccc tttgcctttt
1679761 cttacgccat ctataatcca catccggaac tcttcgggat gaccgcgttg gtagccttca
1679821 gcatttttct gaccagggcc cacacctctc gaacccgggt gatcctcagt acgctgtacg
1679881 gacttacgat ggccgtgctg gcgctcatac acgaagcgat tccactggaa ttcgcactcg
1679941 gcgcggtgct ggcgataatc gtgttgtcga agaatgcgac aggtgcgaca aggcgaatct
1680001 gtactgcgtt ggccatcggt ccggggaccg tctcagtatt gttgctcgct gtggtcgggc
1680061 gtcgcgatat cgcggaccag ttgtgtgccc atatcccgca tgggatggtc gaaaatccgt
1680121 gggcggttgc aacgacaccg cagcgagttc tcgattacat attcggtcgt gtcgagagcc
1680181 atgcagatta ccacgattgg gtgtgcgagc atgtgacccc gtggtttaac ctcgactgga
1680241 ttacctctgc aaagctggtg gccgtggttg gcttccgcgc actattcggt gcattcctcc
1680301 tcgggttgct gttcttcgtt gccacgacat cgatgatccg ctatgtctcc gccgtgccgg
1680361 tcagaacctt ctttgccgaa ctgcgcggca atctggcgtt gccggtgctg gcatcggcat
1680421 tgctggttcc gctgttcatc accgctgtcg actggactcg ctggtgggtg atgatcacac
1680481 tcgacgtggc cattgtctac atcttgtacg cgatcgacag accggagatc gagcaaccgc
1680541 cgtcgaggag aaacgtgcag gtcttcgtct gcgttgtgtt ggtgctggcg gtgataccga
1680601 ccgggtccgc caacaacatc ggcagatgag gcaccccgcg ggaccacccg aaggcgggca
1680661 tggtgacgta ggccaaccgc cgctgacatg cttgggacgg tgatgctgtt gcaggcctat
1680721 taggggttgt cggatcggga gccttgtgac cggttggccc ttgatctgcg ttgggaggcc
1680781 gcggcggggt tgacggtgca cgcgccgtcg ttgcatccca cggtgttggt cgggatgcgt
1680841 aaccggctgc gggcttcgga tccgacgtgt tggtggatgc accattttca aatgccgtcg
1680901 cgggtcgaaa cttgggtgcc gtcgaagaat aaccccacca aaggccctac atcagcgccg
1680961 tcctacgttc gtgtgtcgga caatccttag tgccgatgcc ggatattcgg gcactaacgg
1681021 aaaagacgtc ctccgcgtag aggctccgtt gttcgaggcc cagttacagg ggcaaggtca
1681081 gtggccgtga cctctgcttc ccgacacgag aatgctggcc gaccgaacgt agcgcggtgc
1681141 gttgacggca tcgagctgcc acgccaaatt tgcacgcgct gatgcgctga ccccgaccga
1681201 aggtttatca aatgagagcc ggctcgcgca cagggtcgtc gtaacccggc atgcgtcggt
1681261 gctgccgtcg ataattgcgg atctcataga cgagcccagt cagacctagc gcgcccgtgc
1681321 ataccgacac caggatcagc agcgggctac cgctaccggc gaacgcgtcg cccaggatga
1681381 ccaccgccgc ggtgccgggg agcaagcctg ccaaggtcgc ccaggcgaag gacaggatcc
1681441 gcacgcccga ggcgccggcg gcatagttga tcgccgcgaa cgggacgacg ggaatgagcc
1681501 gcagcgacaa gatggccagc cagcctcgct cacgcagacg ctcgtccagc cggttgatcg
1681561 ctcggcggcg caccagactg ttcagctgcc agccggtggc acgcaccagc agcatcgcga
1681621 ttaccgcgct agcggtgctg ccgaccaccg cgatgaatac gcccaccaca gagccgaaca
1681681 acagcccggc ggccaacgtg aacgcggtgc gggggaatgg cggcaccgtg acgacggtat
1681741 gcaccagcaa aaatgccagc gggaaccacg cgcccagtga cttggcccag tcgcgcaatt
1681801 ccaccgcagt gggcaccgga accagcagcg cgaccactac cagtactgtg attcccacca
1681861 ctgttcccac gatgcgcggc agcgacgcct gacgcgcgac cgcgccgagc gaggtggcga
1681921 taccgtgcac ggtttcggtg gtgttgcaga tggcgggagc cgtcacgtct tcggagcgta
1681981 cggggtcaac atgaataact cgtttcccca ggctggcgtt tcgtcacact ccggccgcga
1682041 ttgccgcacc tgggcgtcta tatgggcgtc ccgatcaact agccttatta gttaagtgac
1682101 aatcccgaag caagcccaag caacatcgct aattgctggg aaaacaggag cagtcggtgt
1682161 ccattgatgt acccgagcgt gccgacctag aacaggttcg cgggcgctgg cgcaacgcgg
1682221 ttgccggtgt gctgtccaag agcaaccgta ccgactcagc acaactcggc gatcaccccg
1682281 agcggctgct ggatacccag accgctgacg ggttcgccat ccgggccctc tacaccgcgt
1682341 tcgacgagct cccggagccg ccgttgccgg gccagtggcc ctttgtgcgc ggcggagacc
1682401 cgctgcgcga cgtgcattcc ggctggaagg tcgccgaggc gtttcccgcc aacggtgcga
1682461 cggccgacac caacgcggcg gtgctggccg cgctcggcga gggggtcagc gcgctgctga
1682521 tccgggtggg ggagtcgggt gtggcgcctg accggctcac ggcgctgctg tccggggtgt
1682581 atctgaacct ggcgccggtc atcctcgacg ccggcgccga ctaccgcccg gcctgcgacg
1682641 tcatgctggc gctggtcgcc cagctcgatc ccggccagcg cgacaccctg tcgatcgacc
1682701 tgggcgccga cccgctgacg gcgtcgctgc gcgatcgtcc cgccccgccg atcgaggagg
1682761 tcgtcgcggt cgcatcccgg gcggccggcg aacgtgggct tcgtgcgatc accgtcgacg
1682821 gaccggcctt ccacaacctg ggcgcgaccg cggccaccga actcgcggcc accgtcgcgg
1682881 ccgcggtggc ctacctgcgg gtgctcaccg aatccgggct cgtggtgagt gacgcgctgc
1682941 ggcagatcag cttccggctc gccgccgacg acgaccagtt catgacgctg gccaagatgc
1683001 gggctctacg tcaactgtgg gcgcgggtcg ccgaggtcgt gggcgacccg ggtggcggcg
1683061 cggccgtcgt gcacgcggag acgtcgctac cgatgatgac ccagcgtgat ccgtgggtga
1683121 acatgctgcg ctgcacgctg gcggccttcg gcgccggtgt cggtggcgcg gacaccgtgc
1683181 tggtgcaccc gttcgacgtg gcgattcccg gcggctttcc cggcacggcg gccggctttg
1683241 cgcgccggat cgctcgcaac acccaactgc tgcttttaga agagtcgcat gtcggcaggg
1683301 tgctcgatcc cgccggcggg tcgtggttcg tcgaagagct caccgaccgg ctggctcggc
1683361 gcgcctggca gcgtttccag gccatcgagg cccgtggcgg cttcgtcgag gcccacgact
1683421 tcctggccgg ccagatcgcc gagtgcgccg cccgccgcgc cgacgacatc gcccatcggc
1683481 gcctggcgat caccggcgtc aacgaatacc cgaacctggg cgaacccgcg ctgccgcccg
1683541 gtgatccgac atcgccggtg cgccgctacg ctgccggatt cgaagcattg cgcgatcgat
1683601 ccgatcacca cctagcccgc actggcgcac ggccgcgggt gctgttgctg ccgttgggtc
1683661 cgctggccga gcacaacatc cggacgacct tcgccaccaa cctgctggcg tccggcggca
1683721 tcgaggcgat cgacccggga acggttgatg cgggcaccgt cgggaatgcc gttgccgatg
1683781 ccggttcgcc cagcgttgcc gtgatctgcg gcaccgatgc gcgctaccgg gacgaggttg
1683841 ccgacattgt gcaagcggcc cgagccgccg gtgtttcgag ggtgtacctc gcgggtcccg
1683901 agaaggcgtt gggagatgcc gcacaccggc ccgacgagtt tttgaccgcg aaaatcaatg
1683961 tggtgcaagc cttgtcgaat ctgctgacgc ggttgggggc ctagatgaca accaagacac
1684021 ccgtgatcgg cagcttcgcc ggcgttccgc tgcatagcga gcgtgccgcg caatcgccca
1684081 cagaggccgc ggtgcacacg catgtcgccg ccgccgcggc ggcgcacggg tacacgcccg
1684141 aacagttggt gtggcacacg ccggaaggca ttgacgtcac accggtatac atcgccgccg
1684201 accgggccgc cgccgaagcc gagggctacc cgctgcacag cttcccgggc gagcccccct
1684261 ttgtgcgcgg cccctatccg acgatgtatg tgaaccagcc gtggaccatc cgccagtacg
1684321 ccgggttttc caccgccgcg gattccaatg cgttttaccg acgcaacctg gccgccggcc
1684381 agaaggggct gtcggtggcc ttcgatctgg ccacccaccg cggctacgac tccgaccatc
1684441 cccgcgtgca gggcgatgtc ggaatggccg gtgtggcaat cgattccatt ctcgacatgc
1684501 gacagctgtt cgacggcatc gacctgtcga ccgtgagcgt gtcgatgacg atgaacggtg
1684561 cggtgctgcc gatcctggcg ctgtatgtgg ttgccgccga ggagcagggc gtggcgccgg
1684621 agcagctggc cggcaccatc cagaacgaca tcctcaaaga gttcatggtc cgcaacacct
1684681 acatctatcc gccgaagccg tcgatgcgga tcatctccga catcttcgcc tacaccagcg
1684741 ccaagatgcc caagttcaac tccatctcca tttccggcta tcacatccaa gaagccggtg
1684801 ccacggcgga tttggagctg gcctacaccc tggccgacgg cgtcgactac atcagggcgg
1684861 gcctgaacgc cggcctggac atcgacagct tcgcgccccg gctatcgttc ttctggggca
1684921 tcgggatgaa tttctttatg gaggtcgcca aactgcgggc cggccggttg ctgtggagtg
1684981 agctggtcgc acagttcgcg cccaagagcg ccaaatccct ttcgctgcgt acacattcgc
1685041 aaacatcggg gtggtcactg accgcccagg atgtgttcaa caacgtggcg cgcacatgca
1685101 tcgaggcgat ggccgccacc caggggcaca cccagtcgct gcacaccaac gccctggacg
1685161 aggcgctggc gctgcccacc gatttttcgg cccgcatcgc gcgcaacacc cagctggtgt
1685221 tgcagcagga gtcgggcacc acgcggccga tcgacccgtg ggggggctcc tactatgtgg
1685281 agtggctgac ccatcggctc gcgcggcgag cccgggcgca catcgccgag gtcgctgaac
1685341 atggcggcat ggcgcaggcc atcagcgacg gcatccccaa gctgcgcatc gaggaggcgg
1685401 ccgcgcgcac ccaggcccgc atcgactccg gtcagcaacc ggtggtcggg gtgaacaaat
1685461 accaggtgcc cgaggaccac gagatcgagg tgctcaaggt cgaaaacagc cgggtgcgcg
1685521 ccgagcagct ggccaaactg cagcggctgc gggcaggccg ggacgagccg gcggtacggg
1685581 ccgcgctggc cgagctgacc cgcgccgccg ccgagcaagg acgcgccgga gcagacgggc
1685641 tgggcaataa tctgctggcc ctggccatcg acgccgcccg ggcccaggcc accgtgggcg
1685701 agatctccga agcgctggag aaggtgtacg gacggcaccg ggccgagatc cgtaccattt
1685761 ccggggtcta ccgcgacgaa gttggaaagg cccccaacat cgcagccgca accgagctag
1685821 tggagaagtt cgccgaggcc gacggccgcc ggcccaggat tctgatcgcc aagatgggcc
1685881 aggacggcca cgaccgcggg cagaaggtga tcgcgaccgc gttcgccgac atcgggttcg
1685941 acgtcgacgt ggggtcgctg ttttccaccc ccgaggaggt ggcgcgtcag gccgccgaca
1686001 acgacgtgca cgtgatcggg gtgtcctcgc tggccgccgg ccatctgacg ctggtgccgg
1686061 cgctgcgcga cgcgttggcg caggtgggca ggcccgacat catgatcgtg gtcggtggtg
1686121 tcatcccgcc gggcgacttc gacgagctgt acgccgccgg ggccaccgcc attttcccgc
1686181 cggggacggt gattgccgac gcggcgattg acctgctgca caggctggcc gagcggctgg
1686241 ggtacacgct ggattagcga gaggcccgcg gtgccgtttc tggttgcatt atccggtatc
1686301 atctcgggcg tgcgtgatca ttcgatgacc gtgcggctcg accagcaaac tcgccagcgc
1686361 ctgcaagaca ttgtgaaagg cggataccgg agcgctaatg cggcgatcgt cgacgccatc
1686421 aacaagcgct gggaggcgct acacgatgag caactcgacg ccgcctacgc ggccgcgatc
1686481 catgacaatc cggcgtaccc gtacgagtct gaggccgaac ggagcgccgc gcgggcccgg
1686541 cgcaacgcca ggcagcagcg ctcggcacag tgaacgcgcc gttgcgtggt caggtctatc
1686601 gatgcgacct cggatacggg gccaaaccgt ggctcatcgt ctccaacaac gcccgcaacc
1686661 gtcacaccgc cgacgtggtg gctgtgcgcc tgacaacaac gcggagaacc ataccgacct
1686721 gggtcgccat gggccccagc gatccattga ccggatacgt caacgcggac aacatcgaga
1686781 ccctcggcaa agacgagctc ggtgactacc tcggtgaggt cacgccggcg acgatgaaca
1686841 aaatcaacac ggcgctcgcg accgcgctgg ggctaccgtg gccatgatgg ccgcatccca
1686901 cgacgacgac accgtcgacg ggttggcgac ggccgtgcgc ggcggtgacc gtgcggcgct
1686961 gccacgggcc atcacactgg tcgagtcgac ccgccccgac catcgtgagc aggcgcaaca
1687021 gctgctgctg cgattgctgc cggactccgg gaacgcccat cgcgtcggca tcaccggggt
1687081 cccgggggtg ggcaagtcga ctgccatcga ggcgctgggc atgcatctga tcgagcgcgg
1687141 gcatcgggtg gcggtgctgg cggtcgaccc gtcgtcgacc cgcacgggtg gatcgattct
1687201 tggtgataaa acccggatgg cgcggctggc ggtgcacccg aacgcctaca tccggccgtc
1687261 cccgacgtcg ggaacgctgg gtggggtgac gagggccacc cgggaaacgg tggtgctgtt
1687321 ggaggcggcc ggttttgatg tgatcctgat cgaaaccgtc ggggtgggcc agtccgaggt
1687381 cgcggtggcc aacatggtcg acacgttcgt gttgctgacc ttggcccgca ccggtgatca
1687441 gttgcagggc atcaagaagg gcgtgctgga gctcgccgac atcgtggtgg tgaacaaggc
1687501 cgacggggag caccacaaag aggcccggct ggccgcccgg gagctgtcgg cggcgatcag
1687561 attgatctat cctcgcgaag cactgtggcg cccaccggtg ctcaccatga gcgcggtgga
1687621 gggcagggga ctggccgagc tgtgggacac cgtcgagcgt catcgccagg tgctcaccgg
1687681 ggccggcgaa ttcgacgccc gtcggcgcga tcagcaggtc gactggacct ggcagctggt
1687741 tcgcgacgcc gtcctggatc gggtgtggtc caatccgacg gtgcgcaagg tccgctccga
1687801 gctcgagcgt cgggtccgcg ccggcgaact gaccccggcc ctggcggctc agcaaatact
1687861 ggagatagct aacctaacgg ataggtaaat aaatccgtgt ttgccgatgg tcgctgcgaa
1687921 atccacgtaa gttcgaccgt gtgatggttg acaccggagt cgatcaccgc gcggtttcgt
1687981 cccacgacgg accggacgcg ggccggcggg tgtttggtgc ggcggaccca cgctttgcgt
1688041 gcgtcgttcg agcctttgcc agcatgtttc cggggcgccg gttcggtggc ggagcgctgg
1688101 cggtgtatct cgacgggcag ccggtcgtcg acgtgtggaa ggggtgggct gatcgggccg
1688161 gatgggtgcc gtggtcggcg gattccgcgc cgatggtgtt ctcggcgacc aagggcatga
1688221 cggccacggt catccaccgg ctggccgacc gggggctgat cgactacgaa gctcccgttg
1688281 ccgagtattg gccggcgttt ggcgccaacg gcaaggcaac cctgacggtt cgtgacgtga
1688341 tgcgacacca ggccggcctg tccggattgc gtggcgcgac gcagcaagac ttgctggatc
1688401 acgtcgtgat ggaagagcgg ctggcggcgg cggtgcccgg gcggctgctg ggcaaatccg
1688461 cctaccacgc gctgacgttc ggttggttga tgtcgggcct ggccagggcc gtcaccggaa
1688521 aggacatgcg cctgctgttc cgcgaggaac ttgccgagcc gttggacacc gacggcttgc
1688581 acctgggtcg gccgccggcc gacgcgccga cgcgggtcgc cgagatcatc atgccgcaag
1688641 atattgccgc caatgcggtg ctgacctgtg cgatgcgccg gctcgcccat cggttctccg
1688701 gcggatttcg ctccatgtat tttcccggcg ccatcgcggc cgtgcagggc gaggcgccgt
1688761 tgctggacgc cgagataccc gcggccaacg gggtggcgac ggcgcgagcg ctggcgcgga
1688821 tgtacggcgc aatcgccaac ggcggcgaga tcgacggcat acggttcttg tcgcgggagc
1688881 tggtcacggg cctgacccgc aaccgacggc aagttctgcc ggatcgaaat ctattggtgc
1688941 ccttaaattt tcatcttggc tatcacggta tgccgatcgg caacgtgatg ccggggtttg
1689001 gtcatgtggg cttgggcggc tcgatcggct ggacagaccc ggagaccggg gtggcgttcg
1689061 cgctggtgca caaccggctg ctgtcaccgt tggtgatgac cgatcacgca ggctttgtcg
1689121 gcatctacca cctgatccgg caggccgccg cccaggcgcg caagcgtggt taccagccgg
1689181 tgacgccatt cggggcgccg tactcggagc cgggagccgc ggcgggctaa tctgcccgcc
1689241 taatcggcct gccggcagcg gcgctcggcg ccacggtgtc gcgatgcttc ccggatgccg
1689301 acctagctcg cggttttggt cgcgatgacg atgtcctgga agcttaggcg tggttcccgg
1689361 ccactccatg agccgtagtg caatggttcg tgcacggcga ggccgaactt gccatagaca
1689421 tccctgacga aggtctccgg caagccgatt gcttcttcgg gccgcttctt gtggattgtc
1689481 cgataacccg gtccctcatg ctggaagttg tgcgcactct ttccttccgc gatgtgggct
1689541 aacgactcgt cattgagcaa gaagtacgtg cacaggcatc gtccgccggg cttcagcacg
1689601 cgggagatct cgtccagata gtgctccacg tccggcggaa acatgtgggt gaacaccgag
1689661 gtaagaaaca ccacatcgaa cgacgcatcc ggatatggaa agcgaaagtc tagtgactgg
1689721 tatttccctt tcgggttgta cagcgagttg tagatgtcgg agacctcgaa ctggaagttg
1689781 gggtgcgccg aggtgatgtg ctcctggcac cacgcgatgg ctttctgcga gatatcgaag
1689841 ccggcgtagc gtccctcgct gttcagatag ccggtgagcg gcaacgccat ccgccccgag
1689901 ccgcagccga cgtcgagcac cgcttcgtcc ggctgcagcc cacacaggtc gaccagatac
1689961 ccgacgaatt cagcaccgac ttccttgtag gcgccgccga cgaattgtcg cagggatttt
1690021 ggaggcagcg cctcggcgga gccaccgtcg gctgaaccgc gtttcgagcg cgtcaggatg
1690081 ttctggaaaa gtcgcttaat gatgcacctc agttatcggc cgcgcttgaa ggttcaggaa
1690141 tcctccaggc ggaagccgac tttcatagtc acctggaagt gcgcgaccgc tccgtcgacc
1690201 aggtggcctc gaattgactg tacttcgaac cagtccagcg cgcgcatggt ctgcgcagct
1690261 cgggccagac cgccctggat tgccgcgtcg acgccgtcgg gcgaggtccc gacgatctcg
1690321 atcactcggt aggtgtgatt gctcatcgtg tcccctcaca ttcttttacc cgctcttacc
1690381 ggccagcggc acaccagaat agtccggtgc catcggggga gccctctacg gccggtcact
1690441 ttgagcactt gccgcgcggc agcttcggcc ggattctctc cgtcctcaat gccgctgccg
1690501 accatcatcc acgtgagttg ctcgtcgtcg ggattgcgac cttcgaccag aagcgcccgg
1690561 cggtgggggt cgatgagcac gacccgggtg gtgcggcgac gccggcggtg gtcatcaact
1690621 acgagagccg gtcgtcggct ggcggcacca tcggccattc aacaacgtca caggtagcgt
1690681 gctgtttgta tcagcagccg aaacgcccag cgctccggcc gaccaaggcg gcagcgacga
1690741 ccgcagcgac aacctggatc gaacgagtcc aaaaccgccg cggacgccac tcggccctcg
1690801 tatgatcccg aggagatacc ctacggggtg gattggggat ggatcggcga tgcgcctctc
1690861 gatcgtaacg actatgtaca tgtcagagcc ttacgtgctg gagttctaca ggagagcgcg
1690921 cgcggcggcg gacaaaatca cgcctgacgt cgagatcatc ttcgtggatg acggctcgcc
1690981 ggacgcagcg ctccagcagg ccgtctcgct gctcgacagc gacccctgtg ttcgggtaat
1691041 tcagctttcg cgaaatttcg gccaccacaa agcgatgatg accggcctgg cgcacgccac
1691101 gggggatctc gtctttctga tcgactcaga cttggaagag gacccggctc tcctagagcc
1691161 gttctatgaa aagctgatct cgacgggcgc cgacgtagta tttggttgcc acgcgcggcg
1691221 gcccggcggt tggttgagga atttcggacc gaaaatccat tatcgggcgt ccgccctgct
1691281 gtgtgacccc ccgcttcatg aaaatactct caccgtgcgg ctgatgacag ccgactatgt
1691341 acgcagcttg gtccagcacc aggagcgtga actttcgatt gccggtctgt ggcagattac
1691401 tggtttttac caggtgccca tgtccgtaaa caaggcatgg aaaggaacga ccacatacac
1691461 gtttaggcgt aaagtagcga cactggtcga caatgtcact tcatttagca acaaacctct
1691521 agtcttcatt ttctatcttg gtgcggccat ttttattatt tcaagctcgg ccgcgggcta
1691581 tctgatcatc gatcgaattt tctttcgcgc tctgcaagcg gggtgggcat ccgtgatcgt
1691641 atccatctgg atgctggggg gtgtgacgat tttctgcata gggctggtcg gaatttatgt
1691701 atccaaagtc ttcatcgaaa ctaagcagcg gccatacaca attatccgaa gaatctacgg
1691761 ttcggattta acaacccggg agccatcctc tctgaagacc gccttcccgg ccgcgcacct
1691821 gtcgaacggg aaacgcgtca catcagagcc agagggattg gcaactggca acaggtgaat
1691881 aagcgtagca tgattcctgt aaaggttgaa aacaatactt cgctcgatca ggtgcaagac
1691941 gctcttaatt gcgtcgggta cgcggttgta gaagatgtgc ttgatgaggc gtcactggca
1692001 gcgacccgtg atcgcatgta tcgtgtacag gagcggattc ttaccgagat tggcaaagag
1692061 cggctggcaa gggccggtga gctcggtgtt cttcgactca tgatgaagta tgaccctcat
1692121 ttctttacct ttcttgaaat acccgaagtc ctaagcatcg ttgatcgtgt gctatctgaa
1692181 acggccatct tacatctgca gaatggcttt atccttccgt ccttcccgcc cttctccacg
1692241 ccggacgttt ttcagaatgc gttccaccaa gactttccca gggttctgtc cggttacatt
1692301 gcctccgtca atattatgtt cgccatcgat ccctttacac gagacaccgg cgcaacgctc
1692361 gtagtgccgg ggagccacca gcgcatagag aaaccggacc atacctacct cgcgcgcaat
1692421 gccgttcccg ttcaatgcgc ggcgggctcg ttgttcgttt ttgactctac gctttggcat
1692481 gcggctggcc gaaacacctc cggcaaagac cgcttggcca taaatcatca gtttacgcgc
1692541 tcgtttttca agcagcagat cgactacgtc cgcgcgctgg gcgacgccgt ggttctggag
1692601 cagcctgcgc gtactcagca actgctcgga tggtacagtc gagtggttac caatctggac
1692661 gagtattacc agccgccgga caagcgattg tatcggaagg ggcaaggcta gttttgcgag
1692721 aattccgttg cgcctatttg aaagcccgac atgaaacgat cgcttttaag cgcatatgtc
1692781 tgttctgcaa aaatgtctaa tttttccgat aaaggttggt gggaaagctc gatgcgtgcc
1692841 gtgttttgta ggtggccgga tgatccactt agacaggccg tggaagcaga atttgcgcgt
1692901 cccgatggcg ttgcggtggc gtaatggcct ggcgaaagct cgggagaatt tttgctccgt
1692961 cgggcgaact cgactggtcg cgaagtcatg ctgcgctacc ggttcctgaa tggatcgagg
1693021 gtgatatttt ccgcatctat ttcagcggcc gcgatggtca gaatcgttcc agtatcggta
1693081 gcgtgatcgt cgatctcgcc gtgggcggca agattctgga cattccggcg gagccgattt
1693141 tgcgccccgg cgctcgagga atgtttgacg actgtggggt gtcaatcgga tcgattgtgc
1693201 gtgccggcga tacgcgactt ttgtactaca cgggctggaa tctcgctgtc accgtgccct
1693261 ggaaaaacac cataggcgtg gcgattagcg aagcaggtgc accattcgag cgatggtcta
1693321 cttttcccgt cgttgcgctg gacgagcgtg atccattctc gctttcttat ccctgggtca
1693381 tccaagatgg agggacatac cgtatgtggt atggctcaaa tctaggctgg ggagagggca
1693441 ccgacgagat acctcacgtg atcaggtatg cgcaatcaag ggacggtgtc cactgggaaa
1693501 agcaggatcg cgtgcatatc gacacaagcg gatccgacaa tagcgcggcc tgtaggccgt
1693561 acgtcgtccg cgatgcggga gtatacagaa tgtggttttg cgctcgcggt gcgaaatatc
1693621 ggatttactg cgctacatcg gaggatggtt tgacttggcg gcaactcggc aaagatgagg
1693681 gcatcgacgt ttcgccagat agctgggact cggatatgat cgagtatcct tgcgtgttcg
1693741 atcacagggg acagcgcttt atgctttatt cgggcgatgg ctacggtcgc accgggttcg
1693801 gtttggcggt gctggagaac tgatcagggc tgacaataga tgtttagcgg ctgatgatgc
1693861 gcttcccgct cgaataggct gagaccatta ttgccgcggt agcgatgatt tcccggatta
1693921 tcgtcgtcgc cgcgatcact cactgctcgt cgaggccctt taagggcttc attgtatcct
1693981 tcgcactgct tatcttcatg cgcgcaacgt caggatgcgc gtgagcgcct cgacaacgcg
1694041 gctctgatct acctcctgaa gtccaaccca catcggcaga cggattaggc gggaagccac
1694101 gtcgttggtg acggtcaggt tgccattggt gcggccgtag cgacgcccgg ccggcgaatc
1694161 gtgaagcggc acgtaatgaa agaccgcgcc tataccttcg ctcgtcagac gcgccagcac
1694221 ctcctcccga tcggcgctgg gcgctagtaa cacgtagtac atgtgggcgt tgtgagagca
1694281 gccctgtggg atgatcggac ggcgcaggag cccccgctgt tccaatgatt cgaagctttc
1694341 atgataccgg ttccataggt ccaatcggat acgcgtgatc cgctcggctt cctcgaactg
1694401 agcccataga aaggcagcga ctaattcgct gggcaaatag gaagaccctt tgtcctgcca
1694461 cgtatatttg tcgacctcgt tgcgaaggaa gcggctgcga ttggtgccct tttccctgag
1694521 aatctctgcc cggagcagga agtcttatga gttgacaagc agggcgccgc cttcgccgga
1694581 aatcacattc ttggtctcgt gaaatgagag cgctcccagg tcgccgatgc tgccgagcgc
1694641 ccgcccacga tacgacgcca tcgcgccttg ggccgcgtct tcgaccaccg ccaggttgtg
1694701 gtgcgtggcg atcttcatga tcgcgtccat ctcgcaggcc acgccggcat agtgaacggg
1694761 gacgatggcc ttggttcgcg gggtgatggc gtctacgatg cgagtttcat caatgttgag
1694821 cgtgtcgggc cgaatatcga caaagactgg cacaccaccg cgcaacacga aggcgttggc
1694881 ggtagagaca aaggtgtatg acggcagtat gacttcgtcc ccctcctcta tgtccagaag
1694941 cagcgccatc atttccagcg cggcggtgca tgagggggtg agtagtgcct tgcgacaacc
1695001 ggtctgctgt tcgagccatg catggctacg ccgggtgaag ggaccatcgc cggccaggtg
1695061 gccgcaagaa tgcgcttcgg cgatgtacgc gagctcccgg ccggtcatgt acggccgatt
1695121 gaatggaact ttgtgatctg acactcgacg ccaacttctc aaatcatcga acagggcgct
1695181 gaagtgttcg gtgatcgggg tcgaacatcc accagaattc tccttgtggc cggcggatcc
1695241 ctagcctttt caggtatccc aacatgcctt cactatttct tcatatcttc cgcaactccg
1695301 tgctgggcac cggacggcgc tccgtcttgg ttcctatata gacaccatcc gcgtcagcgt
1695361 cgccaaggag tagggcgccc gctccgacca cacaccgtga accgatggtg atatggtcgc
1695421 gtagcgttgc attgacgcca atgaaagatt gctcctctat taccacgcca ccggatacga
1695481 cgatatgaga cgctagaaaa cagtgatcgt gaatcgtcga gtgatggccg atatgattgc
1695541 cgctccacaa tgtgacgttg ttgccaatcg atacgaatgg ctggatagtg ttgtcttcaa
1695601 gcaggaagac attttcaccg atccgcccat cgttcaagac ggtagcgtgg gagctcacat
1695661 agctggcgag ttcgtagccg agagccttag cggcaagata tttttccttc cgcacaccgt
1695721 tcagtttggc gtaggccagc gccacgaaca tcgcgtggga ctccggcgga aagcgttgtg
1695781 cgacctcgtc gaaggccact aaaggcaggc cgcaaaactc ggacacgctt gcatagtctc
1695841 ggtcgactgt gaacgcgacg acctcatatt ccgaatccct tgtgaagtag taatgtgcga
1695901 gctgagcgat gtcgccgctc ccaaaaatta ccaatggttt ggtcatgacg ccttcctaac
1695961 cagaattgtg aattcataca agccgtagtc gtgcagaagc gcaacactct tggagtacct
1696021 gcgcttgcag agatcaaata gggcgcatgg gtcagcatag tacaggtcgt cgcgcatctt
1696081 tgatgcatcg gaataagatg tcaggcaatt aaaagagaag ccacggcgac tcgcggcatt
1696141 cagcatgtcg agcgtcgctt cgatgtgagc gcaccattcc gtgtccaacg atttcagacg
1696201 aacattgaat attccactcg cgacgctata gtccgcctcc cgatctatgc gcgccgcgca
1696261 gatgaagtct gcgttcgccc gaccttcgaa acgtagtgcg gccgcgcgca ccatttcggg
1696321 ggagacgtcg atgccggtgt aatcagtttt gaagccacgc gcatctaggt agtccagtag
1696381 agccccatag ccacagccta gatcgttgat cgaaaatggg tccgccgcat tgacaatgcg
1696441 caccagctgg tcaaagcgca acgcctgccc ggcttcgccg ttccaatcga cgccgcgcgg
1696501 gtgccgtgtg cttcgagttt cgatgcgtag taacgggcca cgtcagcgag catggtcgtt
1696561 gcgtcttccg ccatgaagct gcctcacgat ttgtgtgtgt gggcgtcggt gcgtgggtcc
1696621 gagactatac cttcaacagt tgcatgccga ggctgcggcg ggcaatgacc caaaaacccg
1696681 ccggcacggt tcgccgagca aggaagcgtg gagacgatag ataatttcac tggcgacagt
1696741 acctcaaata gtccggagcc tcggctccga cgttaaagag cagatccaga atcgacacgg
1696801 cgggctcgaa ccctccccac aattgcttat aatcgcggta gccgtcataa tcgaaccaag
1696861 ttacccggat gctaagttcg tcgaacacgc gctcatcgac atacgaacgg gctgaggggc
1696921 cagagacata ttcggtcgct gcggcctgtt ggcagaggtt ggccagtctc tcggtcttgc
1696981 cgtcggctaa ttcgtagtcc cacgaatttg ccagtcgcgt gctgataccg agataactgc
1697041 aaatcgcatt caatagacgc ctgttgagta aggaaagatt cgtgtgctgt tcttcgaggt
1697101 aaatcggcgc gagccagtca gcgatctccg caaaatgagc ggccgcgctg tagttgaatt
1697161 ctagtgcccg ccagtgcgct ttcgcccaat cggtgccgtc gatcagcgtc tcacgtatct
1697221 tttgatggaa acgtcccttc acctggacgg gaacagttat ccactgtaac ccctggctcg
1697281 ttttgatccg atttctgttt cgccaatcac gcttggtata ttgcatgtca tcatagatga
1697341 tgaattcatc gacgaatgca atcaggtcaa aatatcctcg ccaaggtatg taatttgatt
1697401 gaacaatcgc gactttcttc aacgcggtgt ctccaattta gaataacaaa tacgtcgcgc
1697461 ccgcgacagc tccgctggag cgagttcaag cgattctgcg acatattcaa tatggtgctc
1697521 gggaaggcca ggatgggccg cgacccgggg cgtccggtgc gcgatgaacg tcgcatcgtc
1697581 tcctgtgaga taattgcatc cgatcatata gggctggctg cggctaggtt gctggcaaaa
1697641 agatatcgcg gccgatccgt ttctggtttt gtcttgatga tcaaatccgc ttccgttcac
1697701 gagatcgatt cctggtcttc ccccagcgtc gcgatgtcga taggtgtcgc gctttgttcg
1697761 tacccgcact acgcggcggc gagaacctcg ccaccgaatc gggattgggg ggaggatacc
1697821 actcggtcga ggcccgtcac cggccttcta gcgggttgac catcagtgtt tgcagggccc
1697881 tatcccggta tggcgcacca cgggatcggc agcgttccgg ttgctggcgt ggtacctcgt
1697941 tgtggcgccg tggtccatgt cgattgagtg cgtggatcag tgtaaaccgt tgcgcgccat
1698001 gttctgtagg cactggttcg ggttgtggtt aggctgcacg gttggcaggt taccaaccac
1698061 tgagcccctg ggcggatgtg agctcggact ccgcctatgg ggtgtaattt tggcagattg
1698121 ggccgggtcc ccgtggtgag gactcctcaa ccggattggg taagcatgag gtggtgctgg
1698181 cagcggtgtc ctggtcgctc tcccgagtag gcccgttgtg actgtcatgt gggcgagcgg
1698241 gtttgcgcgc gtaggagacg atgattacta cgcacgtgac caaccacaag aacggtgccc
1698301 atgtcaccgt ggtgaaaacg agtggcgtgg taccgactac ccctttggct cccagctgtc
1698361 catagagcgg cacgtagaac ggctggcccg ggaccgcgac gttgacgatg ctcagcgcca
1698421 cggccaaact cacgcagacg ccgaccgcgc ggcggcggtc tccatgggct gcgagttggt
1698481 cgaatatccc agcaccagga ggcccgttgg ggtctcgggc taccagtgca gcgattggca
1698541 agacgaaaac gagatagtag aaggcgacgt ccgcggggga gaaggtggcg gtggcgagca
1698601 acacaatccc caccatgaca ggcgggatac ggcgtccgag cgccagcacg gcgaccacga
1698661 ctatgactag gacagcaaac ccgatctgcg ttcgcggacc agtgaggaaa ccctctggga
1698721 tcttgcccga ttgatagttc ttgatgctat cggggatcag caggagtgcc ttgccaaagg
1698781 acacgttccg cgggtctcga agccctccga acgaactatt gaacttgatg atgccgtgga
1698841 tcgactgtgc gatcgtcccc gggaagcctc gtggccacaa cagaaaggct gcgatattgg
1698901 acaccaccac gccggtgatc ccgataccag cccaccgcca ttgtcgagcc gccaacaaca
1698961 ccacgccgag aacgacgaac tgcggcttta ccaggacggc caagatcacc gtgatggtgg
1699021 cgaggcccca ccgctgtcgg gacaacgcca cgaagtaagc cagcgcgatc ggtaccacga
1699081 accctgtcga gttgcctcga tcgatgaccc cccacgccgg gatggccgcg gcgcccagtg
1699141 tcacgaagat gaccactcgc tccagaccac gtgccccccg ggccgcccag atggcgggag
1699201 atatgaccgc catcgttagg gcgaccaggt aacagatcag ccccaagcgc ggcgcaccca
1699261 gccaatggct gggtagtccg aaaatcgcat acggtatgcg ggcgggggcc catgcagcaa
1699321 ccgcggtcgg ctggtaatcg gcgggtagcg agatcaggta gtccgcggga ttgggttgaa
1699381 tcccggcggc ggcgaccatg gcgtagtcgc tgaagcagtg ccgaccgata ttcatgcccc
1699441 aatcaagcca acagtcccca gggactacca aaagagtgga aaagacgtcg accgcgtacc
1699501 actgactgag ggcgtacgcc gtcgccgccg aaatcaccga cgccagcagg atggtgccga
1699561 gcatgagggt gcgctcggat tgggagccga tcgcccagag ccgctcccgg ctcgcggtca
1699621 cggcaccgcg caacacctcc gggggtcgct tcatctggat tctcctcggt tctgcgcgaa
1699681 acggtagcag agcgccatgg ttgccaacgc ggtcgccggg cagtctagac cggatcttcc
1699741 tcgtggcaac cgacaacagg acgtcgttgc cgaaagggcg ctgggcaccg acatctagga
1699801 tgaacccaca gccacgcccc gacgttatgc catggcgaag agcgaccggc aggagcggga
1699861 acccagtgaa gcgagcgctc atcaccggaa tcacaggacc ggacggctcg tatctcgcta
1699921 agctcccgct gaagggatat gtggccgctg gtagcccggc cgaggtctat ttctgctggg
1699981 cgacacggaa ttatcgcgaa ttgtatgggt tgctcgcggt caacagcatc tggttcaatc
1700041 acgaatcacc gcgtcacggc gagacattca tgactcgtaa tcctgcacca tatcgcggtc
1700101 ggcaacgagg cgctgatcga tgcgcagacg ctgatgcgcc ggcccacccg gataggtatc
1700161 agtattgggg cgttccggcc agcgtacgag gcgtgatcga ccgcgcaatg ggtgtttgcg
1700221 ttgagtaata atctgaaccg tgtgaacgca tgcatggatg gattccttgc ccgtatccgc
1700281 tcacatgttg atgcgcacgc gccagaattg cgttcactgt tcgatacgat ggcggccgag
1700341 gcccgatttg cacgcgactg gctgtccgag gacctcgcgc ggttgcctgt cggtgcagca
1700401 ttgctggaag tgggcggggg ggtacttctg ctcagctgtc aactggcggc ggagggattt
1700461 gacatcaccg ccatcgagcc gacgggtgaa ggttttggca agttcagaca gcttggcgac
1700521 atcgtgctgg aattggctgc agcacgaccc accatcgcgc catgcaaggc ggaagacttt
1700581 atttccgaga agcggttcga cttcgccttc tcgctgaatg tgatggagca catcgacctt
1700641 ccggatgagg cagtcaggcg ggtatcggaa gtgctgaaac cgggggccag ttaccacttc
1700701 ctgtgcccga attacgtatt cccgtacgaa ccgcatttca atatcccaac attcttcacc
1700761 aaagagctga catgccgggt gatgcgacat cgcatcgagg gcaatacggg catggatgac
1700821 ccgaagggag tctggcgttc gctcaactgg attacggttc ccaaggtgaa acgctttgcg
1700881 gcgaaggatg cgacgctgac cttgcgcttc caccgtgcaa tgttggtatg gatgctggaa
1700941 cgcgcgctga cggataagga attcgctggt cgccgggcac aatggatggt cgctgctatt
1701001 cgctcggcgg tgaaattgcg tgtgcatcat ctggcaggct atgttcccgc tacgctgcag
1701061 cccatcatgg atgtgcggct aacgaagagg taatgacatg gcgcaagcga catcgggcat
1701121 tcgcgcggca ctttcgcaac ctgctgtgta tgaggcgtat cagcggattg cgggcgctaa
1701181 aagcgggctt gcgtggatca caaccgaccc catccagtcg ttgccaggca tgcgtactct
1701241 cgacctcggt tgctggccag cggtgataca cagctccccg ccagtggacg tgacatgtac
1701301 gagagacggc atgagcgcgg aatgtgcgac cgtgccgtcg agatgaccga cgtcggcgct
1701361 acggcagccc ccaccggacc tatcgcgcgg ggcagcgtcg ctcgggtcgg cgcggcgacc
1701421 gcgttggccg ttgcctgcgt ctacacggtc atctatctgg cggcccgcga cctacccccg
1701481 gcttgttttt cgatattcgc ggtgttttgg ggggcgctcg gcattgccac cggcgccacc
1701541 cacggcctcc tgcaagaaac gacccgcgag gtccgctggg tgcgctccac ccaaatagtt
1701601 gcgggccatc gtacccatcc gctgcgggtg gccgggatga ttggcaccgt cgcggccgtc
1701661 gtaattgcgg gtagctcacc gctgtggagc cgacagctat tcgtcgaggg gcgctggctg
1701721 tccgtggggc tactcagcgt tggggtggcc gggttctgcg cgcaggcgac cctgctgggc
1701781 gcgctggccg gcgtcgaccg gtggacacag tacgggtcac tgatggtgac cgacgcggtc
1701841 atccggttgg cggtcgccgc ggcagcggtt gtgatcggat ggggtctggc cgggtacttg
1701901 tgggccgcca ccgcgggagc ggtggcgtgg ctgctcatgc tgatggcctc gcccaccgcg
1701961 cgcagcgcgg ccagcctgct gacgcccggg ggaatcgcca cgttcgtgcg cggtgccgct
1702021 cattcgataa ccgccgcggg tgccagcgcg attctggtaa tgggtttccc agtgttgctc
1702081 aaagtgacct ccgaccagtt aggggcaaag ggcggagcgg tcatcctggc tgtgaccttg
1702141 acgcgtgcgc cgcttctggt cccactgagc gcgatgcaag gcaacctgat cgcgcatttc
1702201 gtcgaccggc gcacccaacg gcttcgggcg ctgatcgcac cggcgctggt cgtcggcggc
1702261 atcggtgcgg tcgggatgtt ggccgcaggg cttaccggtc cctggttgct gcgtgttgga
1702321 ttcggccccg actaccaaac tggcggggcg ttgctggcct ggttgacggc agcggcggta
1702381 gctatcgcca tgctgacgct gaccggcgcc gccgcggtcg cggccgcact gcaccgggcg
1702441 tatttgctgg gctgggtcag cgcgacggtg gcgtcgacgc tgttgctgct gctgccgatg
1702501 ccgctggaga cgcgcaccgt gatcgcgctg ttgttcggtc caacggtggg aatcgccatc
1702561 catgtggccg cgttggcgcg gcgacccgac tgatttgtgc cccaggtcga caaatcacgc
1702621 cgtctcgtca gtgagcactc cgtcctcggg tccgatcctt ccaggagacg ttgcaacctg
1702681 atttggctca aattggtgcg caccgagggt cgggcacatc gtagggtcgc aacagtcaca
1702741 tgtgtcactg caccgggcga cacccgatgt cccggctctc agcgacagct gtctgacctg
1702801 tggttttgtt cccaagttgg tcgtggctgt gcgggattgg aggtggcgtg ggggtcgcgt
1702861 cgtatggatt ctcctcctcg gttccgcgcg aaacggccgc aggcgcaatg gtcaccaact
1702921 tggccgcggt ggagtctagc ctcacatttt cctggtcgcc cccgacaacc aggaggtcgc
1702981 tgcagaacgg gcgttcccta cccacatcta ctatgaagcg acagcggcgc cccgctgtga
1703041 tggctgagca tgaccgacag aggcgggaag acagtgaagc gagcgctcat caccggaatc
1703101 accggccagg acggctcgta tctcgccgaa ctgctgctgg ccaaggggta tgaggttcac
1703161 gggctcatcc ggcgcgcttc gacgttcaac acctcgcgga tcgatcacct ctacgtcgac
1703221 ccgcaccaac cgggcgcgcg gctgtttctg cactatggtg acctgatcga cggaacccgg
1703281 ttggtgaccc tgctgagcac catcgaaccc gacgaggtgt acaacctggc ggcgcagtca
1703341 cacgtgcggg tgagcttcga cgaacccgtg cacaccggtg acaccaccgg catgggatcc
1703401 atgcgactgc tggaagccgt tcggctctct cgggtgcact gccgcttcta tcaggcgtcc
1703461 tcgtcggaga tgttcggcgc ctcgccgcca ccgcagaacg agctgacgcc gttctacccg
1703521 cggtcaccgt atggcgccgc caaggtctat tcgtactggg cgacccgcaa ttatcgcgaa
1703581 gcgtacggat tgttcgccgt taacggcatc ttgttcaatc acgaatcacc gcggcgcggt
1703641 gagacgttcg tgacccgaaa gatcaccagg gccgtggcac gcatcaaggc cggtatccag
1703701 tccgaggtct atatgggcaa tctggatgcg gtccgcgact gggggtacgc gcccgaatac
1703761 gtcgaaggca tgtggcggat gctgcagacc gacgagcccg acgacttcgt tttggcgacc
1703821 gggcgcggtt tcaccgtgcg tgagttcgcg cgggccgcgt tcgagcatgc cggtttggac
1703881 tggcagcagt acgtgaaatt cgaccaacgc tatctgcggc ccaccgaggt ggattcgctg
1703941 atcggcgacg cgaccaaggc tgccgaattg ctgggctgga gggcttcggt gcacactgac
1704001 gagttggctc ggatcatggt cgacgcggac atggcggcgc tggagtgcga aggcaagccg
1704061 tggatcgaca agccgatgat cgccggccgg acatgaacgc gcacacctcg gtcggcccgc
1704121 ttgaccgcgc ggcccgggtc tacatcgccg ggcatcgcgg cctggtcggg tccgcgctgc
1704181 tacgcacgtt tgcgggcgcg gggttcacca acctgctggt gcggtcacgc gccgagcttg
1704241 atctgacgga tcgggccgcg acgttcgact tcgttctcga gtcgaggccg caggtcgtca
1704301 tcgacgcggc ggcccgggtc ggcggcatcc tggccaacga cacctacccg gccgatttcc
1704361 tgtcggaaaa cctccagatc caggtcaacc tgctggatgc cgccgtggcg gcgcgggtgc
1704421 cgcggctgct gttcctgggc tcgtcgtgca tctacccgaa actcgccccg cagccgatcc
1704481 cggagagcgc gctgctcacc ggtccgttgg agccgaccaa cgacgcgtac gcgatcgcca
1704541 aaatcgccgg catccttgcg gtccaggcgg tgcgccgcca acatggcctg ccgtggatct
1704601 cggcgatgcc caccaacctg tacgggccag gcgacaactt ttcgccgtcc ggctcgcatc
1704661 tgctgccggc actcatccgc cgctatgacg aggccaaagc cagtggcgcg cccaacgtga
1704721 ccaactgggg caccggcacg ccccgacggg agttgctgca cgtcgacgac ctggcgagcg
1704781 catgcctgta tctgctggaa catttcgacg ggccgaccca tgtcaacgtg ggaaccggca
1704841 tcgaccacac catcggcgag atcgccgaga tggtcgcctc ggcggtaggc tatagcggcg
1704901 aaacccgctg ggatccaagc aaaccggacg gaacaccacg caaactgctg gatgtttcgg
1704961 tgctacggga ggcgggatgg cggccttcga tcgcgctgcg cgacggcatc gaggcgacgg
1705021 tggcgtggta tcgcgagcac gcgggaacgg ttcggcaatg aggctggccc gtcgcgctcg
1705081 gaacatcttg cgtcgcaacg gcatcgaggt gtcgcgctac tttgccgaac tggactggga
1705141 acgcaatttc ttgcgccaac tgcaatcgca tcgggtcagt gccgtgctcg atgtcggggc
1705201 caattcgggg cagtacgcca ggggtctgcg cggcgcgggc ttcgcgggcc gcatcgtctc
1705261 gttcgagccg ctgcccgggc cctttgccgt cttgcagcgc agcgcctcca cggacccgtt
1705321 gtgggaatgc cggcgctgtg cgctgggcga tgtcgatgga accatctcga tcaacgtcgc
1705381 cggcaacgag ggcgccagca gttccgtctt gccgatgttg aaacgacatc aggacgcctt
1705441 tccaccagcc aactacgtgg gcgcccaacg ggtgccgata catcgactcg attccgtggc
1705501 tgcagacgtt ctgcggccca acgatattgc gttcttgaag atcgacgttc aaggattcga
1705561 gaagcaggtg atcgcgggtg gcgattcaac ggtgcacgac cgatgcgtcg gcatgcagct
1705621 cgagctgtct ttccagccgt tgtacgaggg tggcatgctc atccgcgagg cgctcgatct
1705681 cgtggattcg ttgggcttta cgctctcggg attgcaaccc ggtttcaccg acccccgcaa
1705741 cggtcgaatg ctgcaggccg atggcatctt cttccggggc agcgattgac gcgccggcgc
1705801 gtcaatctat ttcgacattc gcgtgaagac gttttcccag aatcgactgt tgtaggcgta
1705861 gaactcccgg ccgcgtaggt aggcatgtga tattcgcctt cccccgaacg ggtagcggcg
1705921 atgaaggtcg cccatgcggc gcagatcacc gaagaccgcg cttggttccc ggtgcgagcc
1705981 gacgcccgtg gtgtcgaact cgcacagcac acaccgaatc gtgaccggct cgcataccag
1706041 cgcggcccgc aatatgaatt cctggtcggc ggcgatcccg aaatcaaggt cgtagccacc
1706101 gatcttggcc accagcgatg atccgaagaa cgatgcttga tgcggaacaa cctgcttgcc
1706161 ggccaggaat ttgcgcaggc tgaaaggtat cgggccgcgc acccgatcga gcccgacgag
1706221 acgatccatc ccgaagcccc acaattcgga caccggtccc ttgccggata gcgcctccac
1706281 ggcctgggct accacgtcgg gcccggaaaa acgatcggcg gagtgcaaga accacaacag
1706341 atcacccgat gcgtgcgcga tgccctggtt catcgcgtcg taccgcccgc cgtcgggctc
1706401 ggactgccaa tacgcgaagc ctggttcaca cccggacagg tatgccacca cgtcgtcgcc
1706461 gctgccaccg tcgattacga tgtgctcgat gcgtccccgg tagcgttgcg cccgcacact
1706521 tttcaccgtg cgctgcaacc cgtcgaggtc gttgaacgag atcgttatca ccgagacggt
1706581 cggagcagac gtcaccgagt tcccctaggt tgctggcggc gattgtggat caccgggtct
1706641 tgataccgat gaaggtgcct cgaagattcg ccgcatagga acctccgagc aacgactcgg
1706701 cgatgcttgg ttccaagttg tcgtactcct ccatcaccag gtcgacgccg acgtctttga
1706761 tggcctgaag taggtgctcg cgttgaatcc agaatgaccg gcgattgtcc caggacgccc
1706821 attttgcggt gtcgcgctgg ccaaacgagc ggtcgtcgga aaactcggta aaccacctac
1706881 cgggaagtcc ctcatgttcg gtgggcgccg agagcatgaa cttcaccggc gccggccgcc
1706941 gcagcaaccg atcggtcaat tgtcgtgccg tcgtgggcaa ccggagccat ttatcgctcc
1707001 ggttgatgat cgagaagtgc gtctggagaa tcagcagctt gttcgttacc gacgagaggg
1707061 tttccaggta ttgcttcgga ttctccaggt ggtagaagag gccgcagcag aagacggtat
1707121 cgaagagccc gtggttggcg atgttgaggg cgttgtcgtg gacgaaccgg agattcggca
1707181 ggttggtctt cgatttgatg tagttgcagg ccgccatgtt cagctcgcga acctcgatcc
1707241 cgaggacctg aaatcccatg cgcgcgaacc cgaccgcgta cccgccttcc aagcagccga
1707301 catcggccag gcgtaggtgg ctcttgtccc cgggaaagac ggtttccaga atcccgcgcg
1707361 ccgagatgaa ccaggacgat tcgtctaacg tgcgcgagga ctccggtatc gtcaaggttc
1707421 cgtcgtcgag gcgaacgttg tgggcggtga attgtaccgc gccggccgaa tgttcctgtg
1707481 ccatcacttg gttagcccct tcggctggtc ctgggtttgt cgacatggtc aggctcgaca
1707541 gccgcgtcgg agccgggagg gccacacatc cacgagcccc ctgcggctcg gcgtcgcggc
1707601 ggcgagcttg cgccactggg tcttgagccg ccgcgcgggt gtcgccccgc ggtgctgcag
1707661 cgccagcatg gcgatccggg gatggcgcgc gatggtttcc tgcagcgcgg cgcgcccctc
1707721 cgggcctgga acgttggcga tctggcgaag gatccagtcg gccatgacgg cgatgagctc
1707781 ctcgcgcgcg gggtctcccg ggaacaggtc gagcatcgcg tcaaacgtcg ccgcatgccc
1707841 cggaccctgc gtcaaccaga actttggcgg gtccaccacc tggttgtgcc acatgccttg
1707901 ggcgtggcgg cgatacacgg ccatggtgtc gggcaacatg gcgatgtcgc catgcaccgc
1707961 gtgccggacg tgcagatacc agtccagggg catgacgtcg gcaggaatgt cgtcgtagcg
1708021 ctcgaggcga cggtacacgg ccgagttggt ctggatgaag ttcatcaaga tcaacgcatc
1708081 caggctcaag ttgccccgca cccgaaccgg ggggaacttc gagtccttgg catggccgtc
1708141 ctcccatatc actcggacgg gatggaagca caccgtcgtc ttggggtgcc ggtcgaggaa
1708201 tgcgacctgt ttgcttagct tcagcggatc gatccagtag tcgtccgcct cgcacaacgc
1708261 gacgtactcg ccgcgagcgg ccgacagggc gccggtcagg ttcccattga ggccgaggtt
1708321 ttcggtcctg aagatcggcc ggaacacgtg cgggtaccgc tcggcgtact cacggatgat
1708381 cgccggggtg gcatcggtcg acgcgtcgtc ggcgacgatg atctccaccg ggaagtcggt
1708441 ttgctggtcg agaaagctgt cgaaggcctg acgggcgtag cccgcctggt tgtgagtggt
1708501 cgagacgatg ctcaccttgg ggcaaagctg gggactcacc gtcggccctt ttcctgcgcg
1708561 gccgcaaggg tattgcgatg gcgaacgtga atcgcctgtg cccgccggcc gtcggccgtc
1708621 gtggcctggt ggtcggcgga cgtacggcac acgctggcga agtatagcga gggtgcactg
1708681 acgttgggct cgaaccgcgt ggcgcgcggt gtgggcgcac cgtctcgagt cggtgctggt
1708741 tggctcgcgg cctacaacgg cgctctccgc ggcgcgggcg taccggatat cttagctggt
1708801 caatagccat ttttcagcaa tttctcagta acgctacggg gcgcgccgtg ccgtagtagc
1708861 gtccccactg atgtggacga tggtgctcct tttggggttg gggatggcga ttgacccggc
1708921 gcgtctggga ctcgcggtcg tcatgctgtc gcggcgtcgg cccatgctga atctgttcgc
1708981 cttctgggtg ggcggcatgg tggcgggtgt cggcatcgcg ctagccgtgc tggtgttcat
1709041 gcgcgatgtc gccttggcgg ccatacaagg cgtggtgtcc gcggccaacg agttcaggga
1709101 agcggtcggg atcctggcgg gtgggcgtct gcacatcgtc atcggtgtca tcatgctgct
1709161 gttggccgcg cgcatggtgg ctcgcgcgcg ggcgcaggta ggggtaccgg tagggccagt
1709221 gggggtagcc gacggtggaa tgtcggccct ggcgctagcg cagcgccccc cgggtcttgt
1709281 tgcgcggctg gaagtgcgta ctcaacagat gctgcagggc gacgttgtgt ggccggcgtt
1709341 cgtggtgggc gtcgcctcgt ccgcaccgcc cttcgagagt gtggtggcgt tgacggtcat
1709401 catggcatcg ggagccgaga tcggcactca gctcggcgca tttgtcgtgt tcaccctcct
1709461 ggtgcttgcg gtcatcgaga ttccgttggt cgcctacctg gcgataccgc agcaaaccca
1709521 gcaggttatg ctgcggtttc aggattgggt acggtccaat cgtcggcaga tctccctcac
1709581 catcctgata ggggtcgggt tcctcttttt gtaccagggc gtgactagtc tctgagtcgc
1709641 catgtggtgc ctggtgatgc atcaagcgtg gtatcggtga acccggcgaa accgcttatc
1709701 tcggtgtgca tcccgatgta caacaacggc gccaccatcg agcgctgtct gcgtagcatc
1709761 ctcgaacagg agggcgtcga gttcgagatc gtggtcgttg acgacgactc gtccgacgac
1709821 tgcgccgcga tcgccgcaac gatgctgcga cccggagacc gcttgctgcg aaatgagcct
1709881 cgcctcggcc tcaaccgaaa ccacaacaaa tgtctggaag tcgcgcgcgg cggacttatt
1709941 cagttcgtac atggtgatga tcggctgctc cccggagccc tgcagacact cagccgacgt
1710001 tttgaggatc ccagtgtcgg aatggctttc gccccccgac gggtggagag cgacgacatc
1710061 aagtggcaac aacggtacgg cagggtccat acccgtttcc gcaagctgcg cgaccgcaac
1710121 cacgggccgt cgctggtctt gcagatggta ttgcacggcg cgaaggaaaa ttggatcggc
1710181 gaaccgaccg ccgtgatgtt tcggcggcaa ttggcgctgg acgccggtgg ttttcgcacc
1710241 gatatctacc agctcgtcga tgtggacttc tggcttcggt tgatgctgag gtcggcggtc
1710301 tgcttcgttc cgcacgagct ctcggtgcgc cgtcacacgg cggcgacgga gaccacacgg
1710361 gtgatggcga ctcggcgcaa cgtgctggac cgacagcgca ttctcacctg gttgatcgtg
1710421 gacccgttgt cgcccaacag cgttcgcagc gccgcggcgc tgtggtggat acccgcatgg
1710481 ctggccatga tcgtggaggt ggccgtgctc ggaccgcagc ggcggacgca cttgaaggct
1710541 ttggcgccgg ccccattccg cgagttcgcc cacgcccggc gtcaactgcc gatggctgac
1710601 tagcagtcgc actctgcctg gccgtcgtcg gagccacaga caattccaac ccatttggcc
1710661 tggcggccaa gatgacattt ttacaaggta aggctagcct taagcgtccg cgtatccagg
1710721 acctcgggtc tgttgcgttg tggttgcctc gcatgcgacg gagtgctctg cgccaacggc
1710781 ccaggtcgtc cgagaaggcc agccttgacc tgtacagctg tggcgacccg aacgttgcac
1710841 agcttggcga cgaatgccga gttggtcgag tcggccgatc tgaccgtcac cgaggatatt
1710901 tgctcgcgaa tcgtgtcgct gccagttcac gaccacatgg ccattgccga cgttgcgcgg
1710961 gtcgttgcgc cgttcgggga agggttagcg cgcggtggtt gacccgacag cgacggattc
1711021 gcccaaggtg agtatcgtct cgatctccta caaccaagag gagtacattc gcgaggccct
1711081 ggacggcttc gccgcccaga ggaccgagtt ccccgtcgag gtgatcatcg ctgacgatgc
1711141 ctccacggac gccaccccga ggatcatagg agagtacgcc gcccgctatc cgcagctgtt
1711201 tcggccgatc ctgcggcaga ccaacatcgg tgtccacgcc aatttcaagg atgtgctgtc
1711261 cgccgctcgt ggcgagtacc tcgcactgtg cgaaggcgac gattactgga ccgatccgct
1711321 gaagctgtcc aagcaggtaa agtacctgga ccggcatccg gagacgacgg tgtgttttca
1711381 tcctgtgcga gtgatctatg aggatggcgc aaaagactcc gagttcccgc cgctcagctg
1711441 gcgccgcgac ctgagcgtcg atgccctgct cgcgcggaac ttcatccaaa ccaactcggt
1711501 cgtgtaccgc cgtcagccga gctacgacga catcccggcc aacgtcatgc cgatagattg
1711561 gtacttgcat gtgcggcatg cggtgggcgg cgagatcgcc atgttgcccg agacgatggc
1711621 ggtctaccgt cgccacgctc acggtatttg gcattccgcg tacactgacc gccgaaagtt
1711681 ttgggagaca cgaggccatg ggatggccgc gacgctcgag gcgatgctcg acctagttca
1711741 cggccaccgc gagcgcgagg cgatcgtcgg tgaggtgtcc gcctgggtgc ttcgcgagat
1711801 cggaaagaca cccggccgac agggtcgcgc cctgcttctg aagtccatcg cggaccatcc
1711861 gcggatgacg atgctgtcgc tacaacaccg gtgggcgcaa acgccctggc ggcggttcaa
1711921 gcgccggctg tccaccgagt tatcgagctt ggcggcgctt gcgtacgcca cccgacggcg
1711981 cgcactcgaa ggtcgggacg gcggttatcg cgaaaccact tctccgccga ccggtagggg
1712041 acgtaacgtc cgcggatcac atgcctagat cttgatagat cgcccgtctg gcctctatgg
1712101 atggagcatg cgggatcgga ccggttgccg ccgactcgac gaccgaaaga gccatcaaat
1712161 agccttgcgg cccatctttg agatctgtca acccgccggt cctgatgtcc tccaggctct
1712221 ggtcgggatg agctagtgcg gttcccgaac tcggcatctt cgtcagtcct ggagagaaac
1712281 aacaccagcg aaggtagtgt gatgtccgtg gtcgaatcct ctcttcctgg tgtgctgcgt
1712341 gaacgcgcca gttttcagcc caacgacaaa gcgctcacct ttatcgatta cgagcggtcc
1712401 tgggatggtg ttgaagaaac tctgacgtgg tcgcagttat atcggcgaac gcttaacctc
1712461 gccgcacagc taagagaaca tgggtcgacc ggcgatcggg cattaattct ggcgccacaa
1712521 agcctcgact atgtcgttag ctttattgcc tcgctgcagg ccggaattgt cgcggttccg
1712581 ctttcgattc cccagggtgg tgcccacgac gagcgcaccg tttccgtgtt cgccgatacc
1712641 gcaccggcga tcgttctcac ggcgtcctcg gtcgtcgaca atgtcgtcga atacgtccag
1712701 ccgcagcccg gccaaaacgc accggcggtg atcgaagtcg atcggctgga tcttgatgct
1712761 cggccgagct ccggttctcg ttctgccgct cacggccatc cggatatctt gtacttgcag
1712821 tacacctcgg gttccacgcg cacgccggcc ggtgtcatgg tctcgaataa gaatcttttc
1712881 gccaatttcg aacaaattat gaccagttac tacggcgtct atggcaaggt cgccccgcca
1712941 ggctccaccg tggtgtcgtg gttgccgttc tatcacgaca tgggtttcgt cttgggactg
1713001 atattgccga ttctggctgg catccccgcc gtgctgacca gcccgatcgg tttcctgcag
1713061 cgcccggctc gctggataca gatgttggca agcaacactc ttgcgtttac cgccgcgccg
1713121 aacttcgcat tcgatctggc gtctcgtaag accaaagacg aggacatgga gggcctcgat
1713181 ctcggtggcg tacacggcat cctcaacggc agcgaacggg tgcagccggt gacgctgaag
1713241 cgcttcatcg accggttcgc cccgttcaat cttgacccca aggcgatacg tccgtcgtac
1713301 ggaatggcag aggccacggt atatgtggcc acccgcaagg cgggtcaacc gccaaagata
1713361 gtgcaattcg atccccagaa gctgccggac ggccaagctg agcggaccga aagcgacggc
1713421 ggcacaccgc tggtcagcta cggcatcgtc gacacccagc tggtgcgcat cgtcgacccg
1713481 gacaccggca tcgagcgccc cgcgggaacg atcggtgaga tttgggtgca cggcgacaac
1713541 gtcgccatcg gctattggca gaaacccgag gcgaccgaac gcacctttag cgcaacgatc
1713601 gtcaatccct ccgaaggcac acccgcagga ccatggctgc ggacgggaga ttcgggtttc
1713661 ctctccgagg gtgagctgtt catcatgggg cgcatcaagg acctcttgat cgtgtacggg
1713721 cgcaaccact ctcccgacga tatcgaggcg acgattcaga cgatcagtcc gggccgctgt
1713781 gcggcgatcg ctgtttccga gcatggtgct gagaagctgg ttgccattat tgaactcaag
1713841 aagaaggacg agtccgacga cgaggcggcg gaacgactgg gtttcgtgaa acgcgaagtg
1713901 acctcggcaa tctcgaagtc gcacgggttg agcgtggcgg atcttgtgct cgtctccccg
1713961 ggctcaatcc caatcaccac cagcggcaag atccggcgag cacagtgtgt ggagctgtac
1714021 cgtcaggacg agttcactcg cctggacgca tagcacccac aggcgaggct cccgcaatgg
1714081 ggcgcaatgg ggatcgtcac accagtagca ccagcccctg gaggggcaac aggggaaaac
1714141 tgagttgagc gccaaccgtg cgcactgagg ctcaggtgct cagcttcgcg tcgggctttg
1714201 accccgcgtg accgactgcg ggttcgccga tagacgtgtc atcccaacgg tcgtagctcg
1714261 gtaggccggc aagaccgaac agcggcagcg agtggccgag tagatggtcg acgggttctt
1714321 taccgatgtg ggcgccgtcg ccgttgggtt tcgacacgcc atccacgaca tcgtaggccg
1714381 gcatggcggc atagccgaac agcggaagcg aatgtctgcg caggtggtcg atcaggtact
1714441 ccccgttgcc ttcggctagg tcagcgggct tgccgttggg aaccgacttg gttgccgcct
1714501 tgcttgcgtg cccgttggtg ttgcggacga ccttggtgtg gggcggcttg ggcgccggga
1714561 tcggggcctt gcgtcggtgg cctttcaccc gccgcagcca ccgatcggct ttggtcggcg
1714621 gcgtggatgg gtcgcgtccc agctcggacg gccaccagtt tgcccggcca atcatcgtgg
1714681 tcaaggccgg caccgtgacc gtgcggacca ggaaggtgtc cagcacgatc ccgatgccga
1714741 tggtgaaacc ggcctgagcc atcgtgttga tgctcgcgcc caccagaccg aacatcgacg
1714801 cggcgaagat gagacccgcc gaggtgataa caccaccggt ggagcccacg gttcggatga
1714861 cgccgatgcg tataccgtgt ggtgattcgt cgcggatgcg tgaaatgagc agcatgttgt
1714921 agtcagcgcc gatggcaacc aataatatga aggacagtcc cggcaggctc caatgcattt
1714981 cctggcccag tatcaattgg aaaacgagag ttcctatgcc tagggccgac aagtaagaaa
1715041 tcagcaccga gcctatcaga tatatcggag ccacaagtgc gcgcagcaga atgacgagaa
1715101 tcaagaatac gataacgatc gtcgcaatga cgatgaattt catatcgctg ttgtagtagt
1715161 cgcggatatc ccgcagcgca gtcggaaccc ccgccagacc tatcgtggca tcctcgagtt
1715221 cggtattcgg tcgcgcggaa tccgcaacac ggaggatatc gttgacctga tccatcgcct
1715281 cggtggtggc cggattcagc gcgctctgca cgaagtaccg cgccgcatga ccatcggccg
1715341 acaggaaaat ctgggcgccc ttcttgaact cgtccctcga aaaaatctgc ggtggaatgt
1715401 tgaagcccgc cattgacggc ttgtccgcat cccgcttgat ccccaacagg aagtcggcgg
1715461 cctcgttgag ccctgagccc atctttttga cctgatcgac caattcctgc acgcctgccg
1715521 ccagcgctgc gctgccgtcg gcgagagcgt tggctccttg ctgcatttga gccaatttgg
1715581 tgggtaggcc gtcgaccgct ttgagggtgc tgacgacttg cttcagttgc ccgtccagtg
1715641 tgctcaccgt ccgggcgagt gtctggtatt cctgcgtctg ttgcagggtg acggctagcg
1715701 ctctgatgga cctgagcagg ccgtcgtcct gcgcctggac aatcgccgcc aactgtgcgc
1715761 gcgacgtccg acaggcggga tcgctgttac acaccgggct ggagttgagg gcgttgacca
1715821 tagggctggc ccaagtggcg atttgttcgg catcggtgac ggtcccgctc agattgtccc
1715881 ccagagcccg catgcgcccg acatattggg acgcattttc cagttgtcgg atggtcttgt
1715941 cgccgcccat caggtccatc atggcctgca gggtgttgac tatcccgctc gagctggcca
1716001 cggccccatt gatttcgttg cgtatttggg cgagggcgtc ggccaactgg tgcgcaccgc
1716061 cggtcagctg gtccagctcg cctccgtgct cttcgagcag ggtggtcgct tcgtcgagct
1716121 tgccgcccac ttcaccagcc tgaaacgaga ccttggtctc cttcagaggt tccccgttcg
1716181 gtcgggtcaa gccccgcacc atcacgatgt tgggcaattc tgctatctcg cgggacatca
1716241 tctcgatgtc ggcaagcgcg ccgggtgtcc gcaggtctcg gggggatttg atgaacagca
1716301 ccatcggagt catcgcgttc atcgggaaat ggcggttcat cgcctcgtat cctttgacgc
1716361 tttcgacgtg ctgcggcacc gtcttgagat cgtcgtagtt gaatcggatc agcagcgtgc
1716421 agccggccag ggcgaccagc acaatgagac tgccgaccag gtggatggtg gaccgacgca
1716481 cgatgcgaac acccgaacgc cgccacattc gactggtcag gtcgcgtcgc ggcttgatcc
1716541 agccccgccg tccggtgagt gtcaggatgg cgggcagcag ggtgaccgca cccagcagcg
1716601 acaccgtgat ggcaaccgca attgccgggc ccaccgccga aaacacttcc agtttggtga
1716661 acaccatcgc cagaaatgtg acggcgacgg tggccgccga tgcggtgatc accttgccga
1716721 tggacatcaa cgccttcttg accgccatgt ccgatttttc gccgtggcgc acatagtcgt
1716781 gatagcgact tatcagaaag acggcgtaat cggttcccgc cccgatcatg accgcgctca
1716841 taaagacgat cgcctgcatg ttcacggcca ggccgaactc ggcgagcccg gacaacgtgc
1716901 cctgcgcagt gaccaccgac gctccgatgg tggccagcgg caccagcatg gtcaccaggt
1716961 tccgatagac gaggatcagg atgatcagca cgctgaccgc ggtgccgatc tcgatgatcc
1717021 gcacatcttt ctcgccgagc tccgtcaggt cggcgaccgt ggcgatcgga ccgctgaggt
1717081 ggacggtcag gctggttccc gcgactgttt gcttgacgat cgcggcgacg cgtttgaacg
1717141 ccgcttgtgt ctcaggcgac gcggcatcgc ccgcgaacgt gatgggcagg ttccaagcct
1717201 tgttgtcctt gctggccaac agctccttca tttcggggac ggcgagaaaa tcctgaaccg
1717261 atattttgtc ctgcgtgtcc gcccgcaggt tttcgatcag ttttcggtag acggcctcgt
1717321 cggcgggtcc cagcccgttc tcgttggtca agaggaccaa aaggagggcg gaggtctcaa
1717381 ttttttcctg gaaagccgcg ctcatctcct tttgcaggac catcgatggg gccccgggcg
1717441 gcaggggagc ttgctcgcgc tttgcggctt gcgcctgcag cgttgggagc aacagcgtca
1717501 gcgcggccgc caccgcgatc cagcacccaa tgacgatcag cggccatcgc accacgaagt
1717561 tgccgatacg gtcgaacagt cccccggctt tggcctcgtc atgccttgcc acccgataac
1717621 cgtacaagcc tggcaatcgg tggcgtgggg aaatgacgat aaccgcatta accgtgacgt
1717681 tgccgttact ttggcggcgt ttgaccactg cgggcgtcaa atacgcagat caggggcatt
1717741 tcgtgggatc ggctggcgtg cccgcagccg acgctggcgg gcgggatgcg gcgtccgaac
1717801 agatagctcg ctggactcaa acttgcacgg tcgtgctggt ttgcggtcac ggtccggcaa
1717861 agtgggcatt tcggtcctgg tgcacctcgc ggtcgtgcga cactctcccc gtggctctta
1717921 ggtatcgcct gcagtccaat ccgttggtcg gcaagctcac gaccaagtac ttcttgccgc
1717981 ttggcactcg ccaggtcggc gatcacgtgg tgtttttcaa cttcggctac gaggaggatc
1718041 cgccgatggc gttgccgctg tcggagtccg acgagcccaa tcggtattgc atccagctct
1718101 accaccagac ggccagtcag gtggacctca ccggcaagga ggtgctagag gtcagttgtg
1718161 gcgccggtgg cggggcctcc tacatcgccc gcaacctagg tccggcctcc tacacggggc
1718221 tggacttgaa tccggccagc atcgacctct gccgggcaaa gcaccggctg cccggcctgc
1718281 agttcgtgca gggcgacgcg cagaacctgc ctttccccga cgaatccttc gatgcggtgg
1718341 tcaatgtcga agcctcgcac cagtaccccg actttcgcgg cttcttggcc gaagtggcgc
1718401 gcgtgcttcg cccgggcgga cacttcctct acaccgattc ccgtcgaaat cccgtcgtcg
1718461 ccgaatggga ggcggcgttg gccgatgctc cgctgcgcac gatttcgcag cgggacatcg
1718521 gcgcgcaggc caagcgtggg ttggatgcga acacggcgcg ttcgcaagag gccatcggcc
1718581 gccgcgcacc cgtattgctg gccggcttga cccgctgtgc ggtgcgtgtg ctggactggg
1718641 atctacgtcg cggcggcggg ttcagctatc ggatctactt gttcgccaag gattgattcg
1718701 gcgagaccac acccatgaaa aactcatgaa atttgtcgtg gccagctatg ggactcgcgg
1718761 cgacatcgag ccctgcgcag cggtcggcct ggagctgcag cggcgcggcc atgatgtgtg
1718821 ccttgccgtg ccgcccaacc tgattggttt cgtggaaacg gccgggctgt ctgctgtcgc
1718881 atacggaagc agggactctc aggagcagct cgacgagcag ttcctgcaca acgcgtggaa
1718941 acttcagaac cccatcaagc tgctgcgtga agcgatggcg cccgtcaccg agggctgggc
1719001 ggagctgagc gcgatgttga cgccggtggc cgccggggcc gacctgctgt tgaccggtca
1719061 gatctaccag gaggtggtcg ccaacgtcgc cgagcaccac ggcattccgt tggccgcgct
1719121 gcatttttat ccggtgcgag ccaatggcga gatcgccttt cccgcgcggc tgccggcgcc
1719181 actggtccgc tccaccatca cggccatcga ctggctgtat tggcgcatga cgaaaggtgt
1719241 tgaggacgcg cagcggcgtg aactgggcct gccgaaggcg tcaactcccg cgccgcggcg
1719301 aatggccgta cgcgggtcgc tggagatcca agcctacgac gcgctttgct tcccggggct
1719361 ggcagcggaa tggggcggcc gacgcccgtt cgtcggcgcg ttgacgatgg aatcggcgac
1719421 cgacgcggac gacgaggtcg cttcatggat cgctgccgat acaccgccga tttatttcgg
1719481 ctttggcagc atgccgatcg gatccctggc cgaccgggtc gccatgatca gtgcggcctg
1719541 cgcggagttg ggcgagcgcg cgttgatttg ctcgggaccc agcgatgcga ccggaatccc
1719601 gcagttcgat cacgtgaagg tggtgcgtgt ggtcagccac gcggcggtct ttcccacctg
1719661 ccgtgcggtc gtccaccatg gcggcgcggg caccaccgcc gccggtcttc gagccggtat
1719721 ccccaccttg attctgtggg tcacctccga ccagccgatc tgggctgctc agatcaaaca
1719781 gctgaaagta ggccggggga gacgcttttc aagcgccacc aaagaatcgc tgattgccga
1719841 ccttcgaacg atacttgcgc cggactatgt cacccgagcg cgggagatcg cgtctcggat
1719901 gaccaaaccc gccgccagcg tcacggccac cgccgatctg ctcgaagatg cagcccgccg
1719961 tgcgcgctaa gcgagggtgg cgcttcggcg aatggccttc ggcgcgagga tgatcgttgt
1720021 acgctccgct tgtgtccctg atgattacgg tgccggtgtt tgggcagcac gaatacaccc
1720081 acgcactcgt ggccgacctg gaacgtgagg gcgccgacta tctcatcgtc gacaaccgcg
1720141 gtgattatcc taggatcggc accgagcgag tgagcacacc gggagagaac ctaggctggg
1720201 ccggggggag cgagctcggt ttccgacttg cgttcgcgga gggttactcc cacgcaatga
1720261 cgctcaacaa cgacacccgg gtctcgaagg gatttgttgc cgcgttgctc gactcgcggc
1720321 taccggccga cgccggaatg gtcgggccga tgtttgacgt gggttttccc ttcgcggtag
1720381 ctgacgagaa accagacgcc gaaagctatg ttccgcgagc gcgataccgg aaggtgcccg
1720441 cagtcgaggg aacggcgctg gtgatgtcgc gggattgctg ggatgcggtc ggcggcatgg
1720501 acctgtccac gttcgggcgc tacggatggg ggctcgacct ggatctcgcg ttacgggctc
1720561 gaaagtccgg gtatggcctg tacacaaccg agatggccta catcaaccat ttcgggcgca
1720621 agaccgccaa tacgcacttc ggtgggcacc ggtatcactg gggtgcaagt gcggccatga
1720681 tccggggatt gcgtcgaacg catggctggc ccgccgctat gggtatcttg cgggagatgg
1720741 ggatggccca tcatcgtaag tggcacaagt catttccgct cacctgcccg gcgagctgct
1720801 aggcgtgctc ccaggcgttt ggcgtgccgt cgcctccagc aggtccgcgg ccgcggtgac
1720861 ggcggctgtc ggccgggtca tccgtgtcga gatctcacgt gcccgcgcgg cgcattccgg
1720921 cgccaggatc gatcgtagct ccttgagcaa tgacccgcgg gtgatgttcg taaagcgttt
1720981 ggcagagccg actttgagtc gttggacggc accggcccag atcggttgat cggccacgtc
1721041 ccagagaatc agcgtgggca ttcccgctcg caggccggcg gcggtggtac cggcgccacc
1721101 gtggtggacg accgcgcggc acttgggaag gatggtcgaa tagttgacca ggccgacacg
1721161 tttcacgtgg tcggcatgac gaatgcgggt ggagttggct gccggagaat agatcagggc
1721221 tcgctcgccg agctgtgcgc agacatcgga gatcatggcg agcgtttgga cgggcgtttg
1721281 gacgggcgtg ctgccgaagc cgaagtagat gggtggtgtt ccggcggcga tccacgactc
1721341 gagttcttcg ttgggttcgc tgtgtaactc catggtcagc gggccgacaa acgggcggcg
1721401 gtcgctccat tcggccgcca gtccggggaa aaaaaccggg tcgtaggctt ggatttcggg
1721461 cgctccgcgt tccgccagcc gacgcaccgc cggcgccggt gctggcggta ggcccagttc
1721521 acgtcgttgc gcgcgatcgg catccttgct gacgtacgca tacagccgcc atgagacctt
1721581 catcgtcgcg cgcaccagag tcgccggcgt cggtatcgac gggatcgcga tttggccgtt
1721641 gacctgcatc ggaaagtgat gcagtgccgc agccggaatg tcgtagtact cggcgacgtt
1721701 ggctgccaca ccatgatatg tctggcccgt catcaccagg tcggcgccgt cggccaacgt
1721761 ggtcaacgtc gtgcccatct ccgcccagcc ttcgacgaat agttccttga cggcgcgggc
1721821 gaggttgagc ggattctggg ctctggtgag gttgcggacg aatgccgcga ccgtgttgat
1721881 ctgttcgtcc gagtccgggc cgtaggcgac gccggtcaga cctgccgact cgacgaactc
1721941 gatcaggttg ggcggcactg ccatatgaac tgcgtggcct cgccgccgca gctccacgcc
1722001 aaccgcggcg caaggttcga catcaccgcg ggttccgtgg accgccaaga caaacttcat
1722061 cagcgccttc ccgcgttcga cgtcaggcgg gtgccggcgc gtccctgtcg gccgccaact
1722121 tgtcgcacat cagatccgcc aggccacgaa cggtggtgtt gatttcggtg gcggaaatgc
1722181 ggatcccggt ttcggcttcc acccgcgcac gcagttcctg gctgctcagt gagtccaggc
1722241 cgtactcgct gagcagccgg tcggtgtcga tggtgcggcg taggattagg ccgacctgct
1722301 tggagagtag ccgccgcagc cggtctggcc attcctcgcg gggcaggtcc accagctcgg
1722361 caaggaattt gcttgtgcct gaacggtttt gccccaggga ttggaacttc tccgcgaatg
1722421 ggctgtgctg ggcgaaggct gtcagccagg gtgatccgat caccggggcg tagccgctgt
1722481 aggcgcggtt gtggcgcagc agggtctcga aggcgtaggc gccttcctcg ggggcgatgg
1722541 cgtcgccggt ttgttcggca aaggcgatcg cgcggccgat ctggccccag gcgccccagg
1722601 cgatggaggt ggctggtagg tcttgggctc gccgccagtg ggtgaaggtg tccagccagc
1722661 tgttggccgc ggcgtaggcg ccctgacccg gcgagcccac cagggcggcc gctgaggaga
1722721 atgagcagaa ccagtccagc ggctggtccg cggtggcccg gtgcagttgc caggcgccat
1722781 atgccttggg cgcccagtcg cgttcgatga gttcgtcggt gatgttggcc aaggtggcgt
1722841 cctcgaccac cgcggccgcg tgcagcacgc cgcgcagcgg caaacccgtc gcggtggccg
1722901 ccgtgaccaa ccggtcggcg gtgtccggct gggcgatatc gccgcactcc accactacgt
1722961 cagacccgat cgcgcggacg agttcgatgg tctccaacgc cttttggctg ggctgtgagc
1723021 gcgagctgag cacgatgcgg ccggccccgg cgttggccat cttctcggcc aggaataagc
1723081 ccagcccacc caggccaccg gtgatgatgt aggacccgtc tgaacggaaa acccgagcct
1723141 gttcgggggg aagcaccacg ctgctgcgcc cggcgtgggg gacgtcgagg atgagcttgc
1723201 cggtgtgctc ggccgcgccc atcacccgga tcgcggtggc cgcctcggcc agcgggtaat
1723261 gggtgctctg cggcatcggc agcacaccct cgacggtcaa ccgatacacc gtgctcaaca
1723321 gttcgcggac cgcagccgga tggctcaccg acatcaaccc caggtctaga ccgtagaacg
1723381 ccagattgcg ccggaatggc aagagttcca gtcgggtatt ggagtagatg tcgcgtttgc
1723441 cgatttcgat gaagcggccg cccagggcca gtagtttgag gccggccaac tgtgcggcac
1723501 cggtcacgga gttgagcacg atgtccacgc cgtagccggc ggtgtcgcgg cggatctgct
1723561 cggcgaactc gacgctgcgc gagtcataga cgtgttcgat gcccatgtcg cgcagcaggt
1723621 ctcgacgctt ttcgttgcct gcggtggcgt agatctgggc tccggccgca cgcgcgatcg
1723681 cgattgcggc ctggcccact ccgccggtgg cggagtggat gagcaccttg tcgccggcct
1723741 tgatccgcgc caggtcctgc agcccgtacc acgcggtggc gctggcggtg gtcactgccg
1723801 cggcttgggc gtcggtcagc ccctcgggca gtctggtggc caggcgggcg tcgcaggtga
1723861 cgaacgtggc ccagcagccg ttgggtgaca tgccgccgac ccggtcaccg accttgagtt
1723921 cgctgacccc gggcccgacc gcgctcacca ccccggcgaa atcggtgccc agctgcggct
1723981 gtcgcccgtc gagggtttgg tagcggccga aggtgaccag cacgtcggcg aagttgatgc
1724041 tggacgcggt gacggcgacc tcgatctctc ccgggcccgg cgggacccgg tcgaacgcgg
1724101 cgaactccaa ggtttgcagg tcaccgggag tacggatctg taggcgcatg ccggcctcgg
1724161 cgtggtcgac gacggtggtt tgccgctcct cggggcgcag cggggctggg cacaaccggg
1724221 cggtgtacca ctggtcgttg cgccaggcgg tctcatcctc gccgctggcc gccagcagct
1724281 gacgcgccac cgactccgcg ccggtctgct catccacatc gacatagctg gccttcaaat
1724341 gcggatgctc agcaccaatc acccgcaaca acccccgcat cccaccctgc tcaagattgg
1724401 gtcggtcacc agacaacacc gcctgagcat tgtgggtcag cacatacaac cgcggctctt
1724461 gggccgtgat ctctggaatc tcgcgggcga tacgcaccac atgtttgaca agctcgccgc
1724521 cgcgcacggg ggattccgcg tcggggtcgc cggtctgcgg cgcggtcaac acgaatacgc
1724581 cggtgaaccc gccggtgccg agctggtcgc gcagccgcgc ggcctgggct gcgtggtcgg
1724641 cgcgctgcgg ccaggacatc gttgtgcact gcgcgtcgtg caccttcagc gcgtcggtca
1724701 actgtgcggc caccaaatcc gtagcgtcac acgtgctgat cagcagccag gcgccgggtt
1724761 cggcgtggct gttttcgggc agctcacgtt cgtgccattc gatgctcagc agccgctcac
1724821 ccaaaacccg ggcacgttcg ctggcctgcg acgcgccggt acccaactgc agcccacgca
1724881 ccgccaacac caccgcgccg tgctcgtcca acacgtccag gtcggcttcc acgcccacac
1724941 cgcacgcggt caccgtcgtg cagcagtacc gggcatgacg ggccgaccca taggaccgca
1725001 accgccgcac acccaacggc agcaacaaac caccgtcggc cataccctgg acggcgggat
1725061 gagccgccac cgactggaag cacgcatcca gcagcacggg atgcacgccg taagctttga
1725121 cctgcgagcg aagcgggccc ggtaggttga cctcggccag caccgtgtcg ccggcccctt
1725181 cggcgatgta cgcgtcaacc agacccgcaa aagccggccc taagcgatga ccacgcttgt
1725241 ccagccattg ccgaacctcg gcgccgtcca ccttgtgggg atggctggcc agcagttcgg
1725301 cgatgttttt ctggggtggc tggtccgggg cgtcgtcggc ttcccggaca acgtgcagaa
1725361 ccgcggcgag ttgccgtgtg tacctaccat catggctggt ctctactgtg agtgggacaa
1725421 cgccgggggc ttctaccgtg gcggtgacgc cgatgggggt ttcgtcgtcg agcagcaaca
1725481 tctgctcgaa tcggatgtcg cggacttcgg aggcttcgcc gaggacggcg cgggctgcgg
1725541 ccaacgccat ctcgcagtag gcggctcccg gaagggcggc cgcgccgtgg atttggtgat
1725601 cggccagcca gggttgtgtc acggtgccga cctcgccctg ccagacgtgg cgttccggct
1725661 cctcgggcag gcgcacgtgg gagcccagca atgggtgtac ggcgacggta ttggcgtggg
1725721 cgatgcgacg ggtcgtgtcg tcgagcagca gacgacggtg gttccatgtg ggcagtggtg
1725781 cgttgatcag tcggccggtg gggtagagca cggcgaagtc gacggcggcg ccggcggcgt
1725841 agaggtcgcc ggccagtgcg cgcagcccgt ggggcagtgg ttgttcgcgg cgcatgccgg
1725901 ccagcgcagc cgcggacatg tcgaggctgc gggcggtctg gtcgaccgcg tgggtcagca
1725961 gggggtgggg ggtcagctcg gtgaagaccc ggtagccgtc ttcgagggcg gcttgcaccg
1726021 ccgcggcgaa gcgtacggtg tggcgcaggt tgtccaccca gtagtaggcg tcgcagtagg
1726081 gctcctcgcg cgggtcgaac gaggtcgccg agtagtaggg gatttccggt tgcagcgggc
1726141 tgatttcggc gagcgcttcg gccagttcgt cgaggatcgg gtcgacctgc ggggagtgcg
1726201 atgctacgtc gacggccacc tcacgggcca gcacgtcgcg ttgctcccag gcggccacca
1726261 ggtcgcgtac cgtctgggtg gccccgccga tcacggtgga ctgcggggag gccaccaccg
1726321 cgaccacggc gtcgttgacg ccgcgcgcca tcaactccga aagcacttgt tgagcaggca
1726381 gttccaccga tgccatggcg ccggcgccgg cgatacgggt catcagcgcc gaccgccggc
1726441 agatgacgcg cactccgtct tcgaggcaga gcgcgccggc gaccaccgcg gccgcggact
1726501 cgcccagcga gtggccgatg accgcgccgg gcgctacgcc gtaggacttc attgtggccg
1726561 ccagcgcgac ctgcatggca aacagggtcg gttgcacccg gtcgatgccg gtcacgacct
1726621 cgggggcggt catggcttcg gtcaccgaga agccggattc cgcggcgatc agtggttcga
1726681 tcgcggcgat ggtggcggcg aataccggtt cggtggccag caggtcggcg cccatgcccg
1726741 cccattgcga gccttgcccg gagaacaccc agaccggtcc gcggtcgtct tggccgaccg
1726801 cgggtgggta ggggggttcg ccggtggcga cttcccgcag cgcctcggtc agctccgcgg
1726861 tggtggcggc cagtacggcg gtgcgcaccg gccggtgtcc gcgccggcgg gccagggtgt
1726921 aggccagatc cgccggcgcc agctcgggtc cttgggcgtc gacccaatcg gccagccgcg
1726981 cggcggtctg ccgcagcgcg tcctgcgagc tggccgacag cgcgaacagc agcgcgccgt
1727041 cgataccggg tgtggccggg gtgtcgcctg gtgcaccgga ttcgggggct ggcaccggtg
1727101 cctgctcgac aatggcgtgc acattggtgc ccgtcatgcc atacgacgac accgccgcgc
1727161 gccggggcgt ttcttgatcg gcgccgggcc acggcgtaat ctcttgcggc acaaacaggt
1727221 tggtttcgat tgcggcaagc ttgtcaggca gggccgtgaa gtgcagattc tgtgggacca
1727281 cgccgtgttg gagggccagg accgccttca tcagtcccag cgctccagcg gccgactggg
1727341 tgtggccgaa attggtcttc accgatgcca gcgcgcaggg gccgtcgttg ccgtatacct
1727401 cggccaggct ggcgtattcg atggggtcac ccaccggggt gcccgggccg tgcgcctcga
1727461 ccatgcccac cgtagccggg tccacaccgg ccacatccaa cgcctcccga tacgccgcga
1727521 cctgcgcgga ccgtgatggt gtcgcgatat tgacggtgtg gccgtcttgg ttggcggccg
1727581 tgccacgaat tacggccagg atccggtccc catcggccag cgcatccggc aaccgcttga
1727641 gcgccaacat gacacaaccc tcaccggaga cgaaaccgtc cgcggaaacg tcgaacgcat
1727701 gacagcgccc ggtcgcagac aacatgccca acgccgagcc cgaggcgaac cgccgcggtt
1727761 cgagcatcac gtagacaccg ccggctagcg caatgtcgct ttcgccgtcg tgcaggctac
1727821 gacaagccag gtggatagcg gtgaggccag acgagcatgc ggtatctacc gtgatcgcgg
1727881 gaccctgcaa gcccatggcg tacgccaccc gcccggatgc gaagcaggca ttggtgcccg
1727941 tgttgccgta cggcccttcg aaagtctggt tgtcggcgtg taccaatatg tagtcggtat
1728001 gaaccaaccc cacgaaaacc cctgtccgcg aggccatctg gttcggtgtt aggccgccgt
1728061 gctccatggc ttcccaggag gtttccagca acaagcggtg ctgcggatcg atcgctatcg
1728121 cttctttctc cccgatcccg aagaactcgg gatcaaagtc gccgacgtta tcgaggtacg
1728181 cgccccattt gcagtcggtg cgtccgggca cgccgggttc ggggtcgtag tactcgtcga
1728241 tgtcccagcg gtcggcgggg atctcggtga ccagatcgtc gccccgcagc aacgcctccc
1728301 acaaccgatc gggtgagtcg atgccccccg gcagccggca ccccatacca atgacagcta
1728361 ccggcgtaac acgtgtccta tccacggtct ttgttctctc cttacccacg gttcaagctt
1728421 ttgccagcgg cgtatcgtcg aacttcggtc cgggttgata gaaccgcagc accaaacgca
1728481 cccaccgacc cccacgcttc acgccaaccc tttagttcat tggcgtgaac agcagcgtag
1728541 ccggttgccc cgatatatgt ggaaaaatcg ttcggacgta caaaaaaagt tcctgacgct
1728601 ggcgtcaact cgaaactgcc tcggaagtca tgattgattc atcagtcaat attaaagtcg
1728661 cagctcacaa ctataatacg ccggtgcagc ggacaattgc ggaagcgccg gacgcctcgc
1728721 ggtccgatgt cgcctttccc tgcctcgtcg tcaatatctg atggtggacg accgcccgtg
1728781 ccggaccggc ttaggtagcc agccgggctt cgcgccacgc aatttgccta gtcgtgaaag
1728841 acggattgcc gaagtgtcga aggcaacccg aactccgatg ttcaggttat gccaattggt
1728901 gcccggaaat ccccgaaatc gaaaatgtta cgtgcaggtt tcactggacg gatcaaggcc
1728961 gtcgtcgctg aagctgggcg gctggggcga catcgcgcga tccgccctcg gcgatgcgca
1729021 cgtacgccga ttgcatcgtc tctggatgcc gcgcgatcga gccctgcgcg atcggactac
1729081 tgggggacaa cgcggtgacg gtgctctcct cgtgaaactt gttgacccac atgcacgctt
1729141 gcgcgccgat ccagccatcg ccgaatactc tggcattcat ccggtccagt tgtattgcga
1729201 tgaccgcaga cagcagaagc gcgccggccg gcatcgaggc acgacgggaa cggaagccgc
1729261 cacctagagg atccaacgag catctatgct tttcccttcc cacggccgcg cgtgaggcat
1729321 cctcgctgtg cagcaccgcc aggtcaggga tcaacgcgcc gactatttct ccgtcgatgt
1729381 ggctggactg cacctgctcc gtctctcttt gctgccacca gcgccaggtt ggttgtggaa
1729441 gctgagtcac cgtcgggcga aaccgtcagc gttgacgaag cgttagaggt agtgtgctgc
1729501 cgtggtcgcg tcttcgattc ccaccgcgct gcgcgagcgc gccagtgtgc accccaatgg
1729561 tgcggccatc acctacatcg attacgagca ggactgggcc ggtgttgccg aaaccctgac
1729621 ctggtctcag ttgtatcggc gaatgctcaa tgtcgccgag ccgctccggc atgtgggggc
1729681 gaccggtgat cgggcagtga tactggcacc gcagggaatc gaatacgtcg ttggatttct
1729741 cggcgcgttg caggccggac gtatcgcggt tccgctgccg gttccacatg ccggcgccca
1729801 cgatgagcgt acgatttcgg tgctaagcga cacttcgccc gctgtcattc tgacgacgtc
1729861 gggggccgtt gacgatgtca gagaatgcgc tcagccacag ccaggccagt ccgcaccatc
1729921 aatcgttgag cttgatttgc tggacttaga ttctcggcag cgctcccgca gccctggcgc
1729981 gcgcccaacc ggcagggata cgccggaaac cgcgtatttg caatatactt cgggatccac
1730041 ccgtacgccg gccggtgtca tggtctcgaa caaaaatgtc ttcgccaatt tcgagcagat
1730101 cgtggccgac ttctttgcgc ccgagggggg cgtcgtcccg ccggacctca ctgtggtgtc
1730161 ttggctgccg ctgtaccacg acatgggtct tctattaggc gcgatcatgc cgatcctggc
1730221 gggtgtaccc accgtgttga cgagtccggt ggggttcctt cagcggccgg ctcgatggat
1730281 acaactgctg gcacgtaacg gtcgcacgat ttcggcagga ccgaatttcg ctttcgaatt
1730341 ggcggtgcgt aagacgtcag acgacgacat ggacggactt gacctcgccg gcgtgcacac
1730401 catcctcaac ggcagcgagc gagtacaccc ggcgaccctc aaacgatttg ctgaacggtt
1730461 cggccgcttt aattttgccg ccgcggcgct gcggcccgcg tatggcatgg cggaagcaac
1730521 ggtgtacata gcgacccgta atgtgaacga accaccagaa atcgtcgact tcgaatccga
1730581 gaaactgcct gcgggccaag cgatccggtg cccgagcgga agcggcacac cgctggtcag
1730641 ctacggcgtc ccacggtcac agctagtgcg catcgttgat ccagacacgt gtatcgagtg
1730701 tccgcaggga tcggtcggtg agatctgggt gcaaggtggc aacgttgcgt ccggctattg
1730761 gcacaaaccc gaggagagca agcgcacgtt tggcgccagg attgtcaccc cttcggcggg
1730821 cacacccgaa gcgccttggc tgcgaaccgg ggattcgggt ttcgtctccg gcggcgagct
1730881 gttcatcatc ggccgcatca aggacctctt gattgtgtat gggcgcaacc acgctcccga
1730941 cgacatcgag gcgaccatcc aggagataac ctccggccgc tgtgcggcga tcgcggtccc
1731001 cgaccacggc accgaaaagc tggtcgcgat tatcgaactc aagaaacggg gagactccga
1731061 cgaggatgtg gcggaccggc tgcgcatcgt caagcgtgac gtcgccgcgg cgatatttga
1731121 ttcgcacggt ctgagcgtgg ccgatctcgt tctggtgtcg cccgggtcga ttcccatcac
1731181 caccagcggc aagatcaggc gggcacagtg cgtccagctt taccgacggc gtgagttcac
1731241 ccggttagac gcttgactgc atcgttggag cttgttttcc attgtgctac aaccggtttg
1731301 ctgtctctgt ggcccagtgt tagtgggccg ctcggcattg actgagcacg acacgattcc
1731361 tagtgtgctg gtatgtcgga cggcgcggtg gtacgggcat tggtattgga ggcgccgcgc
1731421 aggctggtcg tgcgccagta ccggctgccg cgcatcggcg atgatgacgc actagtgcga
1731481 gtagaggcct gcgggctgtg cggcaccgat cacgagcaat acacgggcga gctggccggt
1731541 gggtttgcct tcgtacctgg ccacgagacg gtcgggacga ttgcggccat cggtccgcgg
1731601 gcggagcagc ggtggggcgt gtcggccggc gaccgagtag ccgtcgaggt attccagtcg
1731661 tgtcggcagt gcgctaactg tcgtggcggc gagtaccggc gttgtgtacg gcatggcctc
1731721 gctgacatgt acgggttcat cccggttgac cgagagcctg gcctgtgggg cggttacgcc
1731781 gaatatcagt acctggcgcc ggattcgatg gtgttgcggg tggccggtga cctcagcccg
1731841 gaagtggcca ccttgttcaa cccgctgggg gcgggaatac gttggggagt aacgattccc
1731901 gaaaccaaac cgggcgacgt cgtggcggtg ctgggtccag gaatccgggg gctgtgcgcc
1731961 gccgcggcgg caaaaggggc cggtgccggg ttcgtgatgg tgaccgggtt gggaccccgt
1732021 gacgccgacc ggttggcgct ggcggcacag ttcggagccg acctcgccgt cgatgttgcg
1732081 atcgatgacc cggtcgccgc cctgaccgaa cagaccggtg ggctggcaga cgtcgttgtc
1732141 gacgtgaccg ccaaggcgcc agcggcattc gcacaggcga tagcgctagc ccggcccgcc
1732201 gggaccgttg ttgtcgccgg cacccggggc gtgggcagcg gggcaccggg attttcgccc
1732261 gacgtcgttg tgttcaagga gctgcgtgtg cttggcgccc tcggcgtaga cgccaccgcc
1732321 taccgggccg cgcttgatct gttggtgtcc ggtcgatacc ccttcgcaag cctgcctcgc
1732381 cgctgcgtgc ggctcgaagg cgccgaggat ctgctggcta ccatggccgg tgaacgcgac
1732441 ggtgtcccgc ctatccacgg agtgctcaca ccatgacaac atcccgcgtg cccctgttgc
1732501 cggtcgacga ggccaaagct gctgccgacg aagcgggcgt gcccgactac atggctgagc
1732561 tcagcatctt ccaagtgttg ctgaatcatc cgcgactagc gcggaccttc aacgacctgc
1732621 tcgccaccat gctgtggcac gggaccctgg actcacggtt gcgtgagttg gtgatcatgc
1732681 ggattggttg gctcaccgac tgtgactacg aatggaccca acactggcgg gttgcttcag
1732741 ggcttggcgt gtcggccgac gatctgctcg gtgtacggga ttggcaaggg tacaacgggt
1732801 tcgggcccgc tgagcaggcc gtcctggcgg ccaccgatga cgtggtgcgc gagggcgcgg
1732861 tgagtgcgca gagctggtcg gcttgcgagc gggaattaca ttgcgacaaa gtggttctca
1732921 tcgaactcgt tacggtgata agcgcatggc gaatggtcgc ttcgatcctg cacagcctcg
1732981 aggtcccact ggaagacggc gtttccagct ggccgcccga cggcctttcg ccaaggtgac
1733041 tgcgccgagc gtgtaaccat ggcgagattc cgccggcgat ttttccgccc tgagtgcacg
1733101 ttcggcgcag aagcactaga cgatccggta ggtctgcaca gcgtgagcga cgatgttccc
1733161 gtcgggatcg gttgcggtga tctcggtaaa ggtgagttcc ttgcggcgtc gggcagtgcg
1733221 cgcatgacag agcaagtcac accgcttggc ggcgccggtg tactggatgc tcatcgcgac
1733281 cgtggcggcg cgggtgcccc tgtcgaagtc gtggttcgac caagcggcgg cggcaccggc
1733341 ggtgtccatc accgacgcga tcaccccacc gtgaaagtag gtgccgtcat tggtgaggtc
1733401 ggtgcgaaac gggagtcgga tcacgacgtc gtcgggttcg tagcgttcga acacgatgcc
1733461 gagcccgccg atgaacggcg tcctcggcat cagctcacgc accgcctggc gacgtttgtg
1733521 ctgctcttgg gcggtcaacg ggtcggacat ggcaggtaat ctaccctatt agattgacat
1733581 atcaatcaat aactcttagc gtcgtcgcaa tgcggaccag agtcgccgag ctgctcggtg
1733641 ctgagtttcc aatatgcgcg ttcagccact gccgggatgt ggtggcggcg gtgtccaatg
1733701 cgggcgggtt cgggatcctc ggtgccgtcg cacatagccc caaacggctg gagagcgagc
1733761 tgacctggat cgaggagcac acgggtggca agccgtacgg agtcgacgtg ctgctgccgc
1733821 ccaaatacat cggcgccgag caaggcggta tcgatgccca gcaggcccgg gagctcatac
1733881 ccgaagggca tcgcaccttc gtcgacgact tgctggttcg ctatggcatc cccgcggtca
1733941 ccgaccggca gcgttcgtcc tcggccggtg ggctgcacat ctcgcccaag ggttatcagc
1734001 cgttgctgga tgtggccttc gcccatgaca tccggttgat cgccagcgcg ctcgggccgc
1734061 cgccaccgga tctcgtggag cgcgcccaca accatgacgt gctggttgcc gccctagccg
1734121 gcacggcgca gcacgcgcgg cgacacgcgg ctgcgggtgt tgacctgatc gtcgcgcagg
1734181 gcaccgaggc cggaggccac accggcgagg tggcgaccat ggttctggtt cccgaagtcg
1734241 tcgatgcggt gtcgccaacg ccggtgctgg ccgcgggcgg gatcgcccgt ggccgccaga
1734301 tcgctgcggc gttggccctg ggggcggaag gcgtctggtg cgggtcggtc tggttgacca
1734361 ccgaagaagc cgaaacgccc ccggtggtca aggacaagtt tctggccgca acatcctcgg
1734421 acacggtgcg gtcccggtcg ctaaccggca agccggcgcg catgctgcgc acggcctgga
1734481 ccgacgaatg ggatcggcct gacagccccg acccgcttgg catgccgctg cagagcgcgc
1734541 tggtcagcga cccgcagttg cgcatcaacc aggccgccgg ccagcccggg gccaaggctc
1734601 gtgagctggc gacctacttc gtcggacagg tcgtcggctc actcgaccgg gtgcggtcgg
1734661 cccgctcggt ggtgcttgac atggtcgagg agttcatcga caccgtcggg caactgcagg
1734721 ggttggtgca aaggtgagcc gcgctagcgc gcggcggcgc cgagcggtca gcgatgagga
1734781 caagtcgcaa cggcgcgacg agatcttggc cgcggccaaa atagtgtttg ctcacaaggg
1734841 ttttcatgcc accaccgtcg cagacatcgc caagcaggcc ggcctggcgt acgggctgat
1734901 ctactggtac ttcgactcca aggacgactt gttccacgcc ttgatggccg gtgaagagga
1734961 ggcgctgcgc gcgcatgtcg cggccgaact ggcccgcgtt ggcgggtcta ccgaggcgcc
1735021 gcttcgggcc ctgttacagg ccgcggtaca ggccacgttc gagttcttcg aaaccgacaa
1735081 ggctaccgtc aaactactgt tccgtgacgc ttacgcgctt gggggccgat tcgaagagca
1735141 tctcggcgga atctacgagc ggttcatcga cgacatcgaa gccgtcgttg ttgccgctca
1735201 acggcgcggt gaggttgtcg aggccccgtc ccggatggcc gcgtacacgt tggcggcgct
1735261 ggtggggcag ttggcacacc gacggctgaa taccgacgat aacgtcaccg ccgcccaggt
1735321 agccgacttc gtggtgtcgc tggtgctaga cgggctgcgt ccgcgtgcac tggcggtcgg
1735381 ggcccgcggt ggtcgggccg cccgaacctg agcaaaggct gccaaataca tggtgaacgc
1735441 gtaaggattc gcgacacccg cccggatcac gttgaccgag acgggtaggt cgtgcatgat
1735501 cggtccggta agcacctcgt taggtgaggc ggctacacga acataggcca ctgaccccga
1735561 acgtcgagag acgccccggg tcaggacagc tcttcccggc ttaagggttg agcccaggtg
1735621 gcttccggct taccggacac gtcgtgtggt gccgaagctc tgacgagagg ggtgcggatt
1735681 tccggcagtt gccggcatct ctgtactcct gtgacgcgct ttatcgtgcg gacaaccgta
1735741 cgtgtcgtgg ccgtgaggag gtgagggacg catgagttcc ggtgacagtc cggaccgata
1735801 tccgggctct gtttcgtccc gatccggttt ccggcgcgac gttttgcgct gagtcgtcaa
1735861 accaagatca gccttcttgg atcggaaccg ctacgggacg ggaccaactc ggttcagtcc
1735921 atatgtgctc gttttgattt ccgtcctcgc ttgcaactcc gtctaggagg cgatcatgac
1735981 cgctgctctg cacaatgacg tagtaaccgt agcttcggcc cccaagctgc gggtggtgcg
1736041 ggatgtgccc ccggcccccg cgtccaagaa ggttgctcgc cggctcgacg cgcagccttt
1736101 cggcaccgga ggggacccgc tggtcgacgg ggcagctcgt ttgctgagca ttccgctgcg
1736161 ccacctctac gccgcgttgt ggcgcgtcgg gctgctcgag gtccaggcct agtccgatgg
1736221 gcaggcagcc gaccttgcgc cgcgatgtgg atttgcggcg ctgggcgaca atccccgtag
1736281 aatcagggga acggcatcga tccggcgatc accggggagc cttcggaaga acggccggtt
1736341 aggcccagta gaaccgaacg ggttggcccg tcacagcctc aagtcgagcg gccgcgcatc
1736401 ggcgtggcaa gcggggtggt accgcggcgt tcgcgcaccg gcgtggcgtc gtccccgagc
1736461 ctggattgca ggcacgcagt gccgaacggt gctggggcct ggggagacga cgcgcaaagt
1736521 gaccgataac gcatatccaa agctggccgg cggggcaccc gacctcccgg cactcgaact
1736581 cgaggtcctc gactactggt cccgtgacga caccttccgg gccagcattg ctcgccgcga
1736641 tggcgccccc gagtatgtgt tctatgacgg gccgccgttt gccaacggtc tgccgcatta
1736701 tgggcacctg ctcaccggct acgtcaaaga catcgtgccg cgatatcgca ctatgcgcgg
1736761 ttacaaggtg gagcgtcgct tcggctggga cactcacggg ctgcccgccg aactcgaagt
1736821 cgagcgccag cttggcatca ctgacaaatc ccagatcgag gccatgggta tcgccgcctt
1736881 caacgatgcc tgccgcgcat ccgtgttgcg ctacaccgac gagtggcagg cgtatgtaac
1736941 tcggcaagct cgctgggtcg acttcgacaa cgattacaag acgctcgatc tggcttacat
1737001 ggagtcggtg atttgggcct tcaaacagtt gtgggacaag ggcctggcct acgagggcta
1737061 ccgggtgctg ccgtactgct ggcgcgacga aactccgctg tcgaatcacg aactgcggat
1737121 ggacgacgac gtctaccaaa gccgccaaga tcccgcggta acggtgggct tcaaggtggt
1737181 gggtggccaa ccagacaacg ggctagacgg tgcctacttg ctggtgtgga cgacgactcc
1737241 gtggaccctg ccgtcgaacc tcgcagttgc ggtaagcccg gacatcacct acgtacaggt
1737301 ccaggcgggc gatcgccgtt tcgtactggc cgaggcacgg ctggccgctt acgcccgcga
1737361 actcggtgaa gagcccgtgg tgctcggcac ctatcgcggc gccgaactgc tgggcacccg
1737421 ctacctgccg ccgtttgcct atttcatgga ctggcccaac gcttttcagg tgctagcagg
1737481 cgactttgta acgaccgacg atggcaccgg catcgtgcat atggcaccgg cctatggtga
1737541 ggacgacatg gtggtcgcgg aggcggtcgg tatcgcgccg gtgactccgg tcgactccaa
1737601 gggacgcttc gacgtcaccg ttgccgatta ccaagggcag catgtctttg acgccaacgc
1737661 gcagatcgtc cgggacctga agacccaaag cggcccggct gcggtgaatg gcccagtgtt
1737721 gattcgtcac gaaacctacg agcaccctta cccacactgc tggcgatgcc gtaacccgct
1737781 gatctaccgg tcggtgtcgt cgtggttcgt cagggtgacg gacttccgag accgcatggt
1737841 ggagctaaac cagcagatca cgtggtatcc cgaacacgtc aaggacggcc agttcggcaa
1737901 gtggctgcag ggcgcccgcg attggtcgat ctcccggaat cgctactggg gtaccccgat
1737961 tccggtatgg aagtccgacg acccggccta cccgcgcatc gatgtctacg gcagcctcga
1738021 cgagctggag cgcgacttcg gcgtacgccc ggccaatttg caccggccct acatcgacga
1738081 gctcacccgt cccaacccag acgatccgac tggccgtagc acgatgcgac gcattcccga
1738141 tgtgctcgac gtgtggttcg actcgggatc catgccgtat gcccaggtgc actacccgtt
1738201 cgagaacctg gattggttcc agggacacta ccccggcgac ttcatcgtcg agtacatcgg
1738261 gcagacccgt ggctggtttt acacactgca tgtgttggcg accgcgctct ttgaccggcc
1738321 ggcattcaaa acctgtgtgg cgcatgggat tgtccttggt ttcgatggcc agaagatgag
1738381 caagtcgctg cgcaactatc cagacgtaac agaggtgttc gatcgcgacg gctccgacgc
1738441 catgcggtgg ttcctgatgg catcgccgat tctgcgcggc ggcaacctga tcgtcactga
1738501 gcaaggaatt cgcgacggtg tgcgacaagt cctgctgccc ctgtggaaca cctacagctt
1738561 cctggcgctg tatgcaccga aagtcggtac ctggcgcgtc gattcggtgc acgtgctgga
1738621 tcgctatatc ctggccaagc tggcggtgct gcgcgacgac ctcagcgagt cgatggaagt
1738681 ttacgatatt cccggtgcct gtgaacattt gcgtcagttc actgaggcgt tgactaattg
1738741 gtatgtgcga cggtcgcgtt cgcggttctg ggcagaagac gccgatgcca tcgacacgct
1738801 acacaccgtg ttggaggtga ccacgaggct ggccgccccg ctgcttccgc tgatcaccga
1738861 gataatctgg cgtggtctga cacgcgagcg atcggtgcac ctgacggact ggccagcgcc
1738921 cgacctgctg ccgtcggatg ccgacctggt cgccgcgatg gaccaggtcc gcgacgtgtg
1738981 ctcggcggca tcctcgctgc gcaaggccaa gaagctacgg gtgcgcctgc cgctaccgaa
1739041 actcattgtg gcagttgaga atccgcaact tctgaggccg ttcgtcgacc tcattggcga
1739101 cgagcttaac gtgaagcagg tcgaactgac cgatgccatc gacacctatg gccgattcga
1739161 gctcacggtc aacgcccggg tagccggacc acggctgggc aaagatgtgc aggccgccat
1739221 caaggcggtc aaggccggcg acggcgtcat aaacccggac ggcaccttgt tggcgggccc
1739281 cgcggtgctg acgcccgacg agtacaactc ccggctggtg gccgccgacc cggagtccac
1739341 cgcggcgttg cccgacggcg ccgggctggt cgttctggat ggcaccgtca ctgccgaact
1739401 cgaagccgag ggctgggcca aagatcgcat ccgcgaactg caagagctgc gtaagtcgac
1739461 cgggctggac gtttccgacc gcatccgggt ggtgatgtcg gtgcctgcgg aacgcgaaga
1739521 ctgggcgcgc acccatcgcg acctcattgc cggagaaatc ttggctaccg acttcgaatt
1739581 cgccgacctc gccgatggtg tggccatcgg cgacggcgtg cgggtaagca tcgaaaagac
1739641 ctgaggtcga ctgggcgacg agcgtaacgt cacggctgaa aatccgtgcc cgacttcgcc
1739701 gtggcgttac gctcgcggcg cggggacccg atctctaggg cgttgtcgcc cagatccacg
1739761 tcggccaagg ccgatggcag cggctgaggt tgatcgccat agcgaaaact agctcggtag
1739821 ccccaaatag catcacgggt gtggagtccc gctgggtgct gcacctggac atggatgcgt
1739881 ttttcgcctc ggtcgaacag ctcacccggc cgaccctgcg ggggcggccg gtgctggttg
1739941 gcgggctggg tgggcgaggt gtggtggccg gcgcgagcta tgaagcgcgg gcctacggtg
1740001 cccgatcggc catgccgatg catcaggccc gcaggctgat cggggtgacg gccgtggtgt
1740061 tgccgccacg cggggtggtg tacgggatcg ccagccgccg ggtattcgac accgtgcgcg
1740121 gcctggtgcc cgtcgtcgaa cagctttctt tcgatgaagc gttcgccgaa ccgccccaac
1740181 tcgccggggc agtggccgag gacgtcgaga cgttctgcga acggttgcgg cgacgggtgc
1740241 gcgacgagac cggcctgatt gcctcggtcg gagcgggctc gggcaagcag atcgccaaga
1740301 ttgcttctgg tctggccaaa cccgacggca ttcgggtagt ccggcacgct gaagagcaag
1740361 cgcttctcag cggattgccg gtacgacggc tgtggggcat cggcccggtc gccgaggaaa
1740421 agctgcatcg gctcggcatc gagacgatcg ggcagctggc cgcgctgagc gatgccgagg
1740481 cggccaacat cctaggcgcg acgattgggc ccgcgctgca ccggctggcc cgtggcatcg
1740541 acgaccgccc agtggtggag cgcgccgaag ccaagcaaat cagcgccgag tccacgttcg
1740601 ccgtcgatct gaccaccatg gagcaattgc acgaggcgat cgactccatc gctgagcacg
1740661 cgcaccaacg cctgctgcgc gacggccgcg gcgcccgcac catcacggtg aagctaaaga
1740721 aatccgacat gagcacgcta acccgctcgg cgacgatgcc ctacccgacg accgacgccg
1740781 gcgcgctgtt tacggtggcc cgccggctgc tgccggatcc actgcaaatc gggccaattc
1740841 gtcttctggg tgttgggttt tcgggtttga gcgacattcg ccaggagtcg ttgtttgccg
1740901 actcggactt gacgcaggaa acggcggcag cgcattacgt cgaaacaccg ggagcggtcg
1740961 tgccggccgc gcacgacgcc acgatgtggc gggtcggcga tgacgtcgcc caccctgagc
1741021 ttgggcacgg ctgggtgcag ggagcgggcc acggcgtggt caccgtgcgg ttcgaaacgc
1741081 gtggttcagg cccgggctcg gcgcggacgt tccccgtcga caccggcgac atcagcaacg
1741141 ccagcccgct tgacagcttg gactggccgg actacatcgg ccagctatcg gtcgaggggt
1741201 ccgccggcgc ctcagcccca acggtcgatg acgtcggcga ccggtgagtt ggccgccagc
1741261 gcggccatta gcagcacccg ggcctgggac ggcggcagtc gcggtaccat caccgcgcca
1741321 gcctccacca ggtcgtgccc gggaccatag cctgcgccga cccgcgcgcc ggcgacccgg
1741381 gtagacaccg cgatcaccac cggatcgctc ccgtctcgac agtggcgacg gactccctcg
1741441 atcacggcgg ccccggcatt gcccgagccc agcgcctcca gcaccacggc gcgcgcgccg
1741501 gctgccacac aggcgtccat cgccaccgcg tcacttcccg gatagacggc gacgatgtcg
1741561 actcgtggcg ccacggcagc gcccagatcg ccgagatagg gccgcgtctt ggtgcgcgtc
1741621 agccgcaccc cgcccgacgt gaagccaagc gactcgccgg cgaatccgca caggtccggg
1741681 ttggccacct tgtgcaggcc caaaggctgt aacacccggc cgccgaaact caccagcacc
1741741 ccgaggtcgc gggcggctgg gtcggcggcg accgcaagcg cgtcgcgcag attggccggg
1741801 ccatcggcgc cgggggcatc ggcgctgagc atggccccgg tcaacacgac cgggcggcta
1741861 cccgcatagg tgaggtccag ccacagagcg gtctcttcga gcgtatcggt gccgtgagtg
1741921 atgaccaccc catctgcgcc gccgcggaat gcctcctgca ctgcagcgcc tatccggtcc
1741981 caatcggccg gcgtcaactt tgagctgtcc agcgccatga ggtcgactac ttcgatgtcg
1742041 gagtccatgt cgagaccggc gatcagcgtc gccccgcaat gggttggccg tagcacccca
1742101 tcggggccgg cggtggtcga gattgtccct ccagtagtga tgacggtgag gcgggccatg
1742161 atgggatcat tgcgcacgtg gtttgctccc atccggccgc ggggtctggg cgggccatat
1742221 cggccctagg ggatgatgat ggtgtgcctg acgaaccaac aggatcggct gatccgctga
1742281 cctcgaccga ggaagccggg ggggcggggg aacctaacgc tcccgcgccg ccgcgacggc
1742341 tgcgcatgct gctgtcggtc gctgtggtgg tgctcacact cgacattgtc accaaggtgg
1742401 tagctgtcca actgttgccg cccggccagc cggtgtcgat tatcggcgac acggtgacct
1742461 ggactctggt gcgtaattct ggggcggcct tctcgatggc gaccggatac acctgggttt
1742521 tgacgctgat tgcgacgggt gtcgtggtcg gaattttctg gatggggcgg cggctggtat
1742581 cgccgtggtg ggcgctgggt cttgggatga tcctgggcgg tgccatgggc aacctggttg
1742641 atcgcttctt tcgggcaccg gggccgctgc gcgggcacgt cgtcgatttc ttgtcggtcg
1742701 gctggtggcc ggtgttcaat gtcgccgatc cgtcggtagt cggtggcgcc atcctgctgg
1742761 tcatcctgtc gatctttggc tttgacttcg acaccgtagg tcggcgacac gccgacgggg
1742821 acaccgtagg tcggcgcaaa gccgatggct gaccgctcaa tgcccgttcc ggatggattg
1742881 gcgggaatgc gtgttgacac cggactggcc cgcttgctgg gactgtctcg gaccgctgcg
1742941 gctgccctcg ccgaagaggg cgcggtcgag ctgaatggcg tgccggccgg aaagtccgat
1743001 cggctcgtct ccggcgcctt gctgcaggtg cggttgcccg aggcgcccgc gccgctgcag
1743061 aacaccccca tcgatatcga gggcatgacg attctgtatt ccgacgacga catcgttgcg
1743121 gtcgacaaac cggctgcagt tgccgcgcat gcgtcggtcg gctggaccgg accgacggtg
1743181 ctcggcggac tcgccgccgc cgggtaccgg atcaccacat ccggggtgca cgagcggcag
1743241 ggcatcgtgc atcgcctcga cgtcgggacc tccggggtga tggtagtggc gatctccgag
1743301 cgggcgtaca ccgtgctgaa gcgggcgttc aaataccgca cggtggacaa gcggtaccac
1743361 gcgctggttc aaggacatcc agatccgtcc agcggaacga tcgacgcgcc gatcggtcgt
1743421 catcgcggcc atgaatggaa gttcgcgatc accaagaatg gccggcacag ccttacgcac
1743481 tacgacacgc tggaagcgtt cgtggcagcc agcctgctcg acgtgcatct ggaaactggc
1743541 cgcacccacc agatccgggt gcacttcgcc gcgttgcatc acccatgttg cggcgacctc
1743601 gtttacggag ctgatcccaa gctagcgaag aggctcgggt tggaccgtca atggctgcac
1743661 gcgcgttcac tggcgttcgc tcatccggcc gacggccggc gggtggagat cgtcagcccg
1743721 tatccggccg atctgcagca cgcgctaaag atattgcgtg gcgagggttg accggcatca
1743781 cgaggtgcgg cagacgaacg tggcgccatg gaaatcgagg cgcacctcgc cctggtgttc
1743841 ccagtattca atgccttggc gaccataccg ggcgccactg ccggacagtt cgacgaacac
1743901 gatcacttgg tcgcctttcc agttgagcac ggccgtcttc gggtcgaatt ggttgtagaa
1743961 ctgtgcggtc aatgggccgt cctgcgtggg acaccggtag gtgaggacgg gtggagtcgc
1744021 ggtggcggga tcggcgattg ccaattggac cagccgggtc tggtaggcct cctgcacaca
1744081 ggtacgcggg tcggtgtctt gcgcacaagc atcacgcagc atcgtccagc tgctttgtgc
1744141 ggcttccagc gccgccgagc gtcgatgggc cagcgcctgt tgataggcgg tcgaaagccg
1744201 gtggtccaga ctggtcaact gccggtcgtg gcaaaccagt tgctgcacta tggttgccgg
1744261 tttggtgcag tcgagcgact gcccggcggt cggcgaggtt gtgttagccg gagggtttgc
1744321 ggcgcaggcg ctcagaacca gggcggtcac caggacgccg atccatctca tggaaacgga
1744381 ctacccggct accgacgcgg tgtccagcgc gacacgccac agggctcaga ctggtgccgt
1744441 ggtgctctcg cccgatgtga cgtcgaccgc cagcggcgcg atgacgccga ggatttccgt
1744501 gatcgtttcg gagggcacgc cggctgcggt cagcgcgtcg gccaagtgtc cggcgaccag
1744561 gctgaagtgg tgcatggtaa ttccgcgccc ctgatggact tgcttcatcg gcgcaccggt
1744621 atagggctcg ggcccgccaa gcgcggccgc gaaaaactcc acctgcttgc ccttgaggcg
1744681 gctcatgttc gtaccgctga agaaggccga tagttggtca tcggcaagca cacgaacata
1744741 gaagtcctcg acgacgactt cgatggcctc atgcccgccg atcttgtcgt agatgctgat
1744801 cggctcacgt ttgcgcaagc gtgacagtag tcccatcgtg ccaggggacc atgccggcgt
1744861 tgcctgccgg ttaggtcgcg atcacgctcg gattatcagc tgtaacaagc tgattgccgc
1744921 caacgtcgca cagatcccgt cgcaaacaga tccttggtcg ccgcaccggc cggtagtgga
1744981 ctccattcat cagctcatgt gctagtaggt tggcttcatg acccgtgtcc atcaccccac
1745041 gccgccatca ggagctaccc acgatgaatc ttggtgactt aacgaacttc gtcgagaagc
1745101 cgctcgcggc ggtgtccaac atcgtcaaca ccccgaactc ggccgggcga tatcggccct
1745161 tctacttgcg caacttgctc gatgcggtgc agggccgcaa cctcaatgat gctgtcaagg
1745221 gcaaggttgt cctcatcact ggtgggtcat caggcatcgg tgcggcggcc gcgaagaaaa
1745281 ttgccgaggc cggcggcacg gtggtgttgg tcgcacgcac cctggaaaac ctcgagaacg
1745341 tcgccaacga catacgggcg atccgaggca acggtgggac cgcccacgtc tacccgtgcg
1745401 atctatccga catggatgcg attgccgtga tggccgacca ggtgctcggc gacctcggcg
1745461 gcgtcgacat cttgatcaac aacgcgggcc ggtcaattcg gcgctcgttg gagttgtcct
1745521 atgaccggat ccacgattac cagcgaacga tgcagctcaa ctacctcggc gcggtccagc
1745581 tgatcctgaa gttcatcccc ggaatgcgag aacgccactt cgggcatatc gtcaacgttt
1745641 cctcagtcgg cgtgcagacc cgcgcgccgc gcttcggcgc ttacatcgcc agcaaggccg
1745701 cgctggacag cctgtgtgat gcgttgcaag ccgagaccgt gcacgacaac gtccgattca
1745761 ccaccgtgca catggcattg gtaaggactc caatgatcag cccgaccacg atctacgaca
1745821 agtttcccac gctgacgccg gatcaggcgg ccggtgtgat caccgatgcc atcgtgcatc
1745881 ggccccggcg agccagctca ccgttcggac agttcgccgc cgttgccgac gccgtcaacc
1745941 ccgcggtgat ggaccgggta cgtaaccgtg ccttcaacat gttcggcgac tcgtccgcag
1746001 ccaagggaag tgaatcccaa accgacacat cagaactcga caagcgaagc gagacgtttg
1746061 tgcgggccac ccgagggatc cattggtgac accatgagcc ttccgaaacc gaacaatcag
1746121 accaccgttg tgatcaccgg cgcctcctcc ggcatcggtg tcgaattggc tcgtggcttg
1746181 gccggccgcg gcttcccact gatgctagtg gcgcggcgcc gcgagcgcct cgacgaactg
1746241 gccgatcagc tgcgccagga acactgcgtc ggggtggagg tcttgccgct cgaccttgcc
1746301 gatacgcaag cgagggcaca gctggctgat cgcttgcgta gtgatgcgat tgccgggctg
1746361 tgcaacagcg caggtttcgg caccagtggg cgtttttggg agttgccgtt cgcacgcgaa
1746421 agcgaggaag tcgtcctcaa tgctctggcg ttaatggaac tcacccatgc cgcactgcca
1746481 ggcatggtca agcgcggcgc cggtgcggtg ctcaacatcg cctcgatcgc gggtttccag
1746541 ccgattccct atatggccgt gtattcggct accaaagcct ttgtgctgac gttctctgaa
1746601 gccgtgcagg aggagctgca cggaacgggc gtgtcggtga ctgccctgtg cccaggcccg
1746661 gtacccaccg agtgggccga gatcgccagc gccgagcggt tcagcattcc cctcgcccaa
1746721 gtttcgccgc acgacgtcgc cgaagccgcc atcgccggga tgctctccgg taagcgcacc
1746781 gtcgtgccgg gcatagtgcc aaagttcgtc agcaccagcg gcagattcgc tccgcgcagc
1746841 ctgctgctgc ccgcgatccg gatcggcaac cggctgcgcg gcgggcccag ccgctgatgt
1746901 gaggggcgtt ccggcctggt gccgaacgga gtgctgggcc tgggcaatcc cagccggcta
1746961 gccgcgttgt atgggttgca gctggcgcac gagtcgcagt gctgccagat gcacaatttg
1747021 ccctctgcag cgcgacaagt cactgttgcg tgtcgcgagg aggtgggcat aacgaccatc
1747081 cttgccggca gagacgaatg cggcgtgtgt gacaagacag ctgggttgga tggcgccgct
1747141 ccttagcggg ccatagcgca cggcccgctt cgtcgccggc gctagtctca tgcgatggcc
1747201 tctgttgagc tgtccgctga cgtccccatc agcccgcagg acacgtggga ccacgtttcg
1747261 gagctgtcag agttggggga gtggctcgtc atccatgagg ggtggcgcag cgagttgcct
1747321 gatcaactgg gcgaaggcgt ccagatcgtg ggtgtcgcgc gggccatggg catgcgcaac
1747381 cgggttacgt ggcgggtgac caagtgggac ccgccacatg aggtcgcgat gacaggatcc
1747441 gggaagggtg gaacaaagta cggagtcacc ctcaccgtgc gacccacaaa aggcgggtcg
1747501 gcgctggggc tgcgtctcga gctgggcggg cgtgcgctgt tcggcccgct gggttcggcg
1747561 gcggctcgcg ccgtcaaggg cgacgtcgag aagtcgctta agcagttcgc cgagctatac
1747621 ggctagccgc tagaagacac actttgcgac acgcccgaac ggtgtcggtc ctcggtcata
1747681 gactggcgtc cctatgagcg gttcatctgc ggggtcctcc ttcgtgcacc tgcacaacca
1747741 caccgagtat tcgatgctgg acggtgccgc gaagatcacg cccatgctcg ccgaggtgga
1747801 gcggctgggg atgcccgcgg tggggatgac cgaccacgga aacatgttcg gtgccagcga
1747861 gttctacaac tccgcgacca aggccgggat caagccgatc atcggcgtgg aggcatacat
1747921 cgcgccgggc tcgcggttcg acacccggcg catcctgtgg ggtgacccca gccaaaaggc
1747981 cgacgacgtc tccggcagcg gctcctacac gcacctgacg atgatggccg agaacgccac
1748041 cggtctgcgc aacctgttca agctgtcctc gcatgcttcc ttcgagggcc agctgagcaa
1748101 gtggtcgcgc atggacgccg agctcatcgc cgaacacgcc gagggcatca tcatcaccac
1748161 cggatgcccg tcgggggagg tgcagacccg cctgcggctc ggccaggatc gggaggcgct
1748221 cgaagccgcg gcgaagtggc gggagatcgt cggaccggac aactacttcc ttgagctgat
1748281 ggaccacggg ctgaccatcg aacgccgggt ccgtgacggt ctgctcgaga tcggacgcgc
1748341 gctcaacatt ccgcctcttg ccaccaatga ctgccactac gtgacccgcg acgccgccca
1748401 caaccatgag gctttgttgt gtgtgcagac cggcaagacc ctctcggatc cgaatcgctt
1748461 caagttcgac ggtgacggct actacctgaa gtcggccgcc gagatgcgcc agatctggga
1748521 cgacgaagtg ccgggcgcgt gtgactccac cttgttgatc gccgaacggg tgcagtccta
1748581 cgccgacgtg tggacaccgc gcgaccggat gcccgtgttt ccggtgcccg atgggcatga
1748641 ccaggcgtcc tggctgcgtc acgaggtgga cgccgggctt cgccggcgat ttccggccgg
1748701 tccgccggac gggtaccgcg agcgcgccgc ctacgagatc gacgtcatct gctccaaagg
1748761 tttcccatcg tactttctga tcgtcgccga cctgatcagc tacgcgcggt cggcgggcat
1748821 aagggtgggt cccggccgcg gctcggccgc cggctcgctg gtcgcctacg cgctgggcat
1748881 caccgacatc gacccgattc cacacggtct gctgttcgag cggttcctca accccgagcg
1748941 cacctcgatg cccgacatcg atatcgactt cgacgaccgg cgccgcggtg agatggtgcg
1749001 ctacgcagcc gacaagtggg gccacgaccg ggtcgcgcag gtcatcacct tcggcaccat
1749061 caaaaccaaa gcggcgctga aggattcggc gcgaatccac tacgggcagc ccgggttcgc
1749121 catcgccgac cggatcacca aggcgttgcc gccggcgatc atggccaaag acatcccgct
1749181 gtctgggatc accgatccca gccacgaacg gtacaaggag gccgccgagg tccgcggcct
1749241 gatcgaaacc gacccggacg tacgcaccat ctaccagacc gcacgcgggt tggaaggcct
1749301 gatccgcaac gcgggtgtgc acgcctgcgc ggtgatcatg agcagcgagc cgctgactga
1749361 ggccatcccg ttgtggaagc ggccgcagga cggggccatc atcaccggct gggattaccc
1749421 ggcgtgcgag gccatcggtc tgctgaaaat ggacttcctg ggcctgcgga acctgacgat
1749481 catcggcgac gcgatcgaca acgtcagggc caacaggggt atcgacctcg acctggaatc
1749541 cgtgccgctg gacgacaagg ccacctatga gctgctgggc cgcggcgaca ccctgggcgt
1749601 gttccagctc gacggcgggc ccatgcgcga cctgctgcgc cgcatgcagc cgaccgggtt
1749661 cgaagacgtc gtcgccgtta tcgcgctgta ccggcccggc ccgatgggca tgaacgcaca
1749721 caacgactat gccgaccgca agaacaaccg gcaggccatc aaacctattc acccggaact
1749781 cgaagaaccg ctgcgcgaga tcctcgccga gacctacggc ctcatcgtct atcaagagca
1749841 gatcatgcgc atcgcgcaga aggtggcgag ctactcgttg gcccgcgccg acattctacg
1749901 caaggccatg ggcaagaaga aacgcgaggt gctggagaag gagttcgagg gcttctccga
1749961 tggcatgcag gccaacgggt tctctccggc ggccatcaag gcgctgtggg acaccatcct
1750021 gccgttcgct gactacgcgt tcaacaagtc acatgccgcc ggctacggca tggtgtccta
1750081 ctggacggcc tacctcaagg ccaactatcc cgccgagtac atggccggtc tgttgacgtc
1750141 ggtcggcgac gataaagaca aggccgcggt ttatctggcc gactgccgca agctcggcat
1750201 caccgtgctc ccgcccgacg tcaacgaatc tggcttgaac ttcgcatcgg tcggccaaga
1750261 catccgctac gggctgggcg cggtgcgcaa cgttggcgct aatgtcgtgg gctcgttgct
1750321 ccaaacccgc aacgacaagg gcaagttcac cgacttttcg gactacctga acaagatcga
1750381 catctcggcg tgcaacaaga aggtgaccga atcgctgatc aaggcgggtg cgttcgactc
1750441 gctggggcat gcccgcaagg gtcttttcct ggtgcacagc gatgcggtgg actcggtgct
1750501 gggcaccaag aaggccgagg cactggggca gttcgatctc ttcggcagca atgatgatgg
1750561 gaccggcacc gcagatcccg tgttcaccat caaggtgccc gatgatgagt gggaggacaa
1750621 acacaaactc gccctagagc gcgagatgct gggactgtac gtctcggggc atcccctcaa
1750681 cggtgtggca cacttgctgg ctgcccaggt cgacaccgcg atcccagcga tcctcgacgg
1750741 cgatgtcccc aacgatgccc aagtgcgggt gggcggcatc ctggcgtcgg tgaaccggag
1750801 ggtcaacaaa aacggaatgc catgggcttc agcgcaattg gaggatctca cgggcggcat
1750861 cgaggtgatg ttcttcccgc acacctactc cagctatggt gccgacatcg tcgacgatgc
1750921 cgtcgtgctg gtcaacgcca aggtggcggt ccgtgacgac cgcatcgcat tgatcgccaa
1750981 tgacctcaca gtgcccgact tttccaacgc cgaggtggag cggccgctgg cggtcagctt
1751041 gcccacccgg cagtgcacct ttgacaaggt gagtgcgctc aaacaggtgt tggcgcgcca
1751101 ccccggcacc tcgcaggtgc atctgcggct catcagcgga gaccggatca ccacgctggc
1751161 acttgatcag tcgttgcggg tgacgccgtc gccggcgttg atgggtgacc tcaaggagct
1751221 gctcggccct ggatgtctgg ggagttagcg aggcgaccgc ccccagcggt ttccgcacga
1751281 tcgcccgtga gcgccgctaa tggatccagc ccgacgcccg actgtccccg ttgagatacc
1751341 ccgagacctc gtcgtcgaag ttggcgaagc ccgacatgag gctgccgaag ttgaagaagc
1751401 cagagatcga ggttcccgca ttgacgaaac ccgaaatgtt ggccgtaccg gtgatcgtgg
1751461 gtaccgagtt tctgaagccc gacagatggt cacccacgtt gatgatgccg gcgttgtagt
1751521 tgcccacgtt ggccaggccc gagttaccgg tgacaaattc ggcgtgttcg tcacgggcgt
1751581 tgttatcgaa gcccgagttg aaggtgccgg cgttagcgta gcccgagttg ttggtgcccg
1751641 tgtgcagcca gccggagttc tgtaccggct ggttgaccga gttgaacaat ccggtgttga
1751701 gatcgcccga gttgaagaag ccggtgttga tgttgccgga gttgaagtag ccggtgttca
1751761 cgttgcccga gttgaaatcg cccgtgttca tgctgccggc attgaagcta cccgtgttgg
1751821 tatggccgga gttaaacaga cccatgctgc cggtgaccag gtttccgccc gagtttccga
1751881 ttccggtgtt cgtggtgccc gagttgaacc agccggtatt ggtggtgccg gagttgaacc
1751941 agccggtgct ggtggtggcc gagttgaacc agcccgtgct gagctggccg gagttgccga
1752001 taccggtact gagctcgccg gagttgccga agcccgagct gcgctcggcc gaactgccga
1752061 actccacgct cagcgccccg actccattgc ccgagtttcc catgccgatg ttgttattgc
1752121 ccgagttgaa aaagccgata ttaccgttgc ccgagttccc gaagccgagg ttcccgctac
1752181 ctgaattgag ggcgccgaaa cctatctggt tatcaccggt gagcccgaag ccgatgttgt
1752241 tgttgccgct gttcccaaac ccgatgttat gagagccctt gttgccgaaa ccgatatttc
1752301 cactgccaag gttgccgctg ccaaagttgg tgtcgccggt gtttccgtta ccaaagttga
1752361 cgttaccggt gtttccgaac ccgaaattcg agttcccggt gttgccgcca cccacgttga
1752421 gatttccggt gttaccgccg ccaaagttgg tgtcgccggt atttccacta cccaggttat
1752481 agctgccgag gttgccgccg cccaggttat agctgccgat gtttccgcta ccccagttga
1752541 gcgtgcccgt gtttccactg tccgggttga gatccccggt gttgccgcca cccaggttgt
1752601 agctgccgat attgccgctg cccaggttga gatcaccgat attggcgttg cccaagttga
1752661 cgctgcccgt gttggcgcta cccgggttga agctgcccag gttgccgagg cccagattgc
1752721 cgctggccag attgaagcca ccgatggtga cgttgcccag atcgagaaac ggaaaccccg
1752781 cgatgatcac cgcaccgccg ggcgtggctg ccgcgctcgg cgacggtgtg aacggcgtca
1752841 gcgacaaggc gaccgccgac gcctcgccgt gataaccgag catcgcggcg acatcggcgg
1752901 cccacatctg ctcatagacg gcctcgacgg ccgcgatggc cggggcgttt tgccccaaca
1752961 gattcgaggc caccaaggag cgcaaccgac ctcgattggc gctcaccgcg cccggatgca
1753021 ccgtcgccgc cagcgccgcc tcgaacgccg ataccgccgc ctgggcttga cccgccgcct
1753081 gctcagcctg cgctgcggcc gtggtcagcc agcgagcata ggacgcggcc acgcctgtca
1753141 tggccgctga cgccggacct tgccaggacc cggtggccaa ctgcgaggtc accgccgaaa
1753201 atgaggccgc cgccgaaccc aaatcgccgg ccagcccggt ccaggccgac gccgccgcca
1753261 acatcggtcc cggcccggca ccagcgaaca tcagcgccga attgatctcc ggcggcaaca
1753321 ccgaaaaatt catcacaacc atcccgtcag ccggccacac ccaccgggct tcacggcgct
1753381 gtctggcccc aaccgcagcg aagcctacga aaaagccggg cgcttcggac gggcgcaggt
1753441 taaatccagg taacgcgtga cgaatctcgc gaggagcctc cttgcggcca tgggccgcca
1753501 cgggtctcgg tggtcgcggc cccgtgcttc cgcgtccttc gattgtggac gtacgctcac
1753561 cgatgtgacc tgggccatac tgatccgctg tcaaggagaa cggaaatgac cacaacagag
1753621 cgcccgacaa ccatgtgcga ggcgttccag cgcaccgccg tcatggaccc ggacgccgtt
1753681 gcgctacgga cccccggcgg taaccagaca atgacatggc gagactacgc ggcgcaggtg
1753741 cggcgggtcg ctgccggcct ggcaggtttg ggagttcggc gcggcgacac ggtctcgctg
1753801 atgatggcga accggatcga gttctacccg ctcgacgtcg gtgctcagca cgtcggcgcc
1753861 acctcgtttt cggtgtacaa caccctgccc gccgagcagc tgacctacgt gttcgacaac
1753921 gcggggacca aggtggtcat ctgcgagcaa cagtacgtcg atcgcgttcg cgccagcggt
1753981 gtgcccatcg aacacatcgt ctgcgtcgat ggcgcgcccc cggcacgctc tcgctgacgg
1754041 atttgtacgc ggccgcctcc ggcgacttct tcgacttcga gtcgacgtgg cgtgccgtac
1754101 aacccgagga cattgtcacc ctcatctaca cgtccggcac aacgggaaac cccaagggtg
1754161 tggagatgac ccacgccaac ctgctgttcg aggggtatgc catcgacgag gtgctcggaa
1754221 tccggtttgg cgatcgggtg acgtccttcc tgccatcggc gcacatcgcc gatcggatga
1754281 ccgggctgta cctgcaggag atgttcggca cccaggtcac cgcggtggcc gacgcgcgca
1754341 cgatcgcagc cgcgctcccc gacgtgcggc caaccgtgtg gggggccgtt ccccgggttt
1754401 gggaaaagct taaggccgga atcgaattca ccgtcgctcg tgagaccgac gagatgaagc
1754461 ggcaggcgtt ggcgtgggcg atgtcggtgg ctggcaaacg cgccaacgcc ctgctcgcag
1754521 gtgaatctat gtcggatcag ctggtcgccg aatgggccaa agccgacgag ttggtgttgt
1754581 ccaagttgcg cgagcggctg ggcttcggcg agctgcggtg ggccctgtcc ggagcggcgc
1754641 cgatccccaa ggagacgctc gcgttcttcg caggtatcgg catcccaatc gccgagattt
1754701 ggggaatgtc ggagctgagc tgcgttgcca ccgccagcca tccccgcgac gggcggctgg
1754761 gcaccgtcgg aaaactactt cccgggctgc agggcaagat cgccgaagac ggtgagtacc
1754821 tggtccgcgg tccgctggtg atgaagggtt atcgcaaaga accggccaag accgcggagg
1754881 cgatcgactc cgacggctgg ctacacaccg gagatgtctt cgatatcgac tccgacggct
1754941 atctgcgggt ggtggaccgc aagaaggagc tgatcatcaa tgcggccgga aaaaacatgt
1755001 cgccggccaa catcgagaac accatcctgg ccgcgtgccc catggtcggg gtgatgatgg
1755061 caatcggtga cgggcgaacg tataacaccg cgctgttggt cttcgacgcc gactctctcg
1755121 gtccgtatgc ggcccagcgt ggcctcgatg cctcgcccgc ggctctggcg gctgacccgg
1755181 aggtgatcgc gcgcatcgcc gccggcgtgg ccgagggcaa cgccaaatta tcgcgggtcg
1755241 aacagatcaa gcggttccgc atattgccca ccctgtggga gcccggcggg gacgagataa
1755301 ccctgacgat gaaactcaag cgccgtcgaa tcgccgcgaa atattccgcg gagatcgagg
1755361 agctctacgc cagcgagctg agaccgcagg tttacgagcc cgctgccgtg ccatcgacac
1755421 aaccggcatg acgggggcta gccagtgact gcacgggagg tgggccgcat cggactgcga
1755481 aagttgctgc agcgcatcgg tattgttgct gaatcaatga cgccgctagc gaccgacccc
1755541 gttgaggtta cccaactgct ggatgcccga tggtatgacg agcggctgcg tgcgctggcc
1755601 gacgagctcg gacgcgatcc ggacagcgtg cgcgccgagg cggcaggcta tctgcgggag
1755661 atggccgcct cgctggatga gcgggccgtg caggcatggc gcggcttcag tcgctggctc
1755721 atgcgcgcct acgacgtact ggtcgacgag gaccagatca cgcagctgcg caagcttgat
1755781 cgcaaagcca ccctggcgtt cgcgttctcg catcgttcgt acttggatgg gatgctgctg
1755841 cccgaggcga tcctggccaa ccggctctcg ccggcgctga ccttcggcgg ggcgaacctg
1755901 aacttctttc cgatgggcgc ttgggccaaa cgtaccgggg ctatcttcat tcggcgtcag
1755961 acgaaagata ttcccgtcta ccgcttcgta ttacgtgctt acgccgcgca gctggtgcaa
1756021 aaccatgtca acctcacctg gtcgatcgaa gggggtcgga ccagaacggg caagctacgg
1756081 ccaccggtgt tcgggatcct gcgttacatc accgatgcgg tcgacgaaat cgacggtccc
1756141 gaagtgtatt tggtgccgac ctcgatcgtg tacgaccagc tgcacgaggt ggaagccatg
1756201 accaccgagg cctatggcgc ggtgaaacga cccgaagacc tgcgctttct ggtccggttg
1756261 gcgcgacagc agggcgagcg actgggccgc gcctatctcg acttcggcga accgctgccg
1756321 cttcgcaagc gcctgcagga gatgcgcgcc gacaagtcgg gcaccggcag cgagatcgaa
1756381 cggatcgcgt tggatgtcga gcaccggatc aaccgcgcca caccggttac ccccaccgcg
1756441 gtggtgagtc tggccctgct gggcgcggac cgctcgttgt ccatcagcga ggtgttggcg
1756501 acggttcgcc cgttggccag ctacatagct gcccgcaact gggcggtggc cggcgccgcc
1756561 gatctgacga atcgctcgac gatccggtgg accttgcatc agatggttgc ttccggcgtg
1756621 gtgagtgtct acgacgcggg caccgaggcg gtgtggggca tcggcgagga ccagcacctg
1756681 gtggcggcgt tttaccgcaa caccgcgatc catatcctgg tcgatcgggc cgtcgccgag
1756741 ttggcgttgc tggcggccgc agagaccaca acaaacggct cggtttcccc ggcgaccgtg
1756801 cgtgatgagg cgttgagcct tcgcgacttg ctgaagttcg agttcttgtt ttctggccgt
1756861 gcccagtttg agaaagacct cgcaaacgag gtactgctga tcgggtcggt ggtcgacacc
1756921 tccaagcccg cggccgcagc cgatgtgtgg cgcctgctgg aatcggccga tgtgctgctg
1756981 gcccacctgg tgctgcggcc gtttctcgat gcctaccaca ttgtcgccga tcggctggcc
1757041 gcccatgaag acgactcttt cgacgaggaa gggtttctgg ccgagtgtct acaggtcggc
1757101 aagcagtggg agctgcagcg caatatcgcc agcgccgagt ccaggtcgat ggagctgttc
1757161 aagaccgcac tgcgcctggc tcgccatcgc gagctggtcg acggtgccga tgcgacggac
1757221 atcgccaaac gccgacagca gttcgccgac gagatagcca cggcaaccag gcgggtaaac
1757281 acaatcgcag aactggcccg caggcaatga gcgacaaatg cggccgccag ggccgctgcg
1757341 ccgtccagcg aacgggtcaa acggtggacg cgccatcccc ccgggcatag tctgaatgtg
1757401 atctaggtca cgtgccagca ccggaggagg cgggactatg gtcgcgacca ctacgcactt
1757461 cccgaagcaa aaagcgccct gcgggcacat ggttgacggc gatcaccaca tcgagcgcga
1757521 cgacgaaggc cttgcctacg acgacctcaa gttttcctgc ggctgccgcg aaatccggca
1757581 tttctaccac gacggatcca tgcgggtacg cacgattcga cacgacggca aggtgttgaa
1757641 ggacgagcac agcggcgatc acgaagcgtg aaccagcgcg atgaccgccc aacacaacat
1757701 cgtggttatc ggcggcggtg gtgcgggtct gcgcgccgcg attgcgatag ccgaaaccaa
1757761 tccgcacctg gatgtggcga tcgtttccaa ggtgtacccg atgcgcagcc acaccgtctc
1757821 ggctgagggc ggcgccgcgg cggtgaccgg tgacgacgac agcctcgatg aacacgcgca
1757881 cgacacggta tccggtggcg actggctgtg tgaccaagat gcggtcgagg ctttcgtggc
1757941 cgaggcgccc aaagagttgg tgcagctcga gcattggggc tgtccgtgga gccgtaaacc
1758001 agacgggcgc gttgccgttc gcccgttcgg cgggatgaag aagctgcgca cctggtttgc
1758061 cgccgacaag acgggatttc acctcctgca cacgttgttt caacggctgc tcacctattc
1758121 cgacgtcatg cgctatgacg agtggttcgc tacgacgctg ctggtcgacg acggcagggt
1758181 atgtggtctg gtcgctatcg agttggcgac cgggcgcatc gagacgatcc ttgccgacgc
1758241 ggtgattctg tgcaccggcg gatgcgggcg ggtatttcca ttcaccacca acgcgaacat
1758301 caagaccggc gacggcatgg cgctcgcatt ccgcgcgggc gcgcccctaa aagacatgga
1758361 attcgtccaa taccacccca ccggactgcc gttcaccggg atcttgatca ccgaggccgc
1758421 acgagctgaa ggcggctggc tgctcaacaa agacggctac cgctacctcc aggattacga
1758481 cctcggcaag cccacgcccg agcccaggct gcgcagtatg gagctcgggc ccagggaccg
1758541 actgtcgcag gccttcgtac acgagcacaa caaaggaagg acggtcgaca ccccgtacgg
1758601 ccccgtcgtc tatctagacc tgcggcacct gggggcggac ctgatcgatg caaagttgcc
1758661 gttcgtacgt gagctgtgcc gcgactacca gcacatcgac cccgtggtcg aattggtccc
1758721 ggtacgaccg gtagtgcact acatgatggg tggcgttcac accgatatca acggcgccac
1758781 aacgcttccc gggctatatg ccgcaggtga aacagcctgc gtgagcatta atggcgccaa
1758841 ccgcctgggg tcgaactcgc tgcccgagct gctggtgttc ggggctcgag cgggccgtgc
1758901 cgccgcggat tacgcagcgc gccaccaaaa gtcggaccgt ggcccgtcgt cggcagtgcg
1758961 ggctcaggcc cgcaccgagg ctctacggct agagcgtgag ctcagccgcc atggccaggg
1759021 aggcgaacga atcgcggata ttcgggcgga catgcaggcc accttggaaa gcgccgcggg
1759081 tatttatcgt gacggaccca ccctcaccaa agcggtcgag gagattcggg tgctgcagga
1759141 acgattcgcc acggcgggca tcgacgatca cagccgcaca ttcaacaccg agctgactgc
1759201 gctgctcgag ttgtcgggga tgctcgacgt tgcactggcg atcgtcgaat cgggtttgcg
1759261 ccgagaagaa tcccgtggcg cacaccagcg aaccgacttt ccgaaccggg acgacgagca
1759321 tttcttggcg cacaccttgg ttcatagaga aagcgacgga acgctgcggg tcggctacct
1759381 tccggtcact atcactcgct ggccaccggg cgaacgcgtg tatgggaggt aaggatgatg
1759441 gatcgaattg tcatggaggt ctcccggtat cggcccgaga tcgaatcggc cccgacattt
1759501 caggcctacg aggttcccct cacccgcgaa tgggcggtgt tggacggcct gacctacatc
1759561 aaggatcacc tcgacggaac actctccttc cgctggtcgt gccggatggg tatctgcggc
1759621 agtagtggta tgacgatcaa cggcgaccca aagctggcgt gcgcgacatt ccttgccgat
1759681 tacctacccg ggccggtgcg ggtggagccg atgcgaaact tcccggtgat ccgcgatctc
1759741 gttgtcgaca tcagtgactt catggccaag ctgcccagtg tgaagccgtg gctcgtccgg
1759801 catgatgaac cgcccgtcga agacggcgaa taccggcaga ccccggccga actcgatgca
1759861 ttcaagcagt tcagcatgtg tatcaactgc atgttgtgct actcggcgtg cccggtgtac
1759921 gcgctggacc ccgacttcct cggtccggcg gcgatcgcgc tggggcagcg gtacaacctg
1759981 gactcgcgcg accaaggtgc ggcggatcgc agggatgtcc tggccgcggc cgacggcgct
1760041 tgggcgtgca ccctggtggg cgaatgttcg acggcttgtc cgaaaggcgt cgatcctgcc
1760101 ggcgcgatcc agcgctacaa gctgaccgcg gccacgcacg cgctgaagaa gttgctgttc
1760161 ccttgggggg gcggatgagc gcctatcgcc agccggtcga aagatactgg tgggcgaggc
1760221 ggcgttctta cctgcgattc atgcttcgcg aaatcagttg catcttcgtg gcctggtttg
1760281 ttctctatct gatgctggta ttgcgcgccg ttggcgcggg cgggaattcc taccagcggt
1760341 ttttggactt cagcgccaat ccggttgtcg tagtgctgaa cgtcgtcgcg ttgagtttcc
1760401 tgctgctgca tgctgttacc tggttcggat cggcaccgcg cgcgatggtg attcaggttc
1760461 gcggccgccg ggtacccgct cgcgcggtcc ttgctgggca ctacgcggca tggctggtgg
1760521 tttcggtgat cgttgcctgg atggtgctgt catgactccc tcgacatcgg atgccaggtc
1760581 gcgccgacgc tcggcggagc ccttcctgtg gctgctgttc agcgccgggg gcatggtcac
1760641 cgccctggtt gcgcccgtcc tgctgttgct gttcggactc gcgtttccgc tcgggtggct
1760701 cgacgcgccc gaccacgggc acctactggc gatggtgcgc aacccgatca ccaagcttgt
1760761 tgtgctggtc ctggtggtac tggccctgtt ccatgcggcg caccggttcc ggttcgtgct
1760821 cgaccatggg ctgcaactgg gccggttcga ccgagtgatc gccctgtggt gttacggcat
1760881 ggccgtgttg ggctcggcga cggcgggttg gatgttgctc actatgtaaa gtcgctggcc
1760941 gggcgctttg gccgccggca cggtacggta cggacctgta ccaccacaac ggttctatgg
1761001 taggcgctgt gacccagata gcggatcggc ctacagaccc ctcgccctgg tcgccgcgag
1761061 agaccgagtt actggcggtg acactacggc tgctgcagga gcacggttat gaccggctaa
1761121 cagtggatgc cgttgcggcg agcgcccgcg ccagcaaggc aacggtctac cggcgctggc
1761181 cgtcgaaagc cgaattggtg ctggccgcgt tcatcgaggg catccgccag gtcgcggtcc
1761241 cgcccaatac cggcaacctg cgcgacgact tgctgcgact gggggagctg atctgtcggg
1761301 aggtgggcca acacgccagc accatccgcg cggtgctcgt cgaagtgtcg cgcaatcctg
1761361 ccctcaacga cgttttgcag catcagttcg tcgaccaccg taaggccctg atccagtaca
1761421 tcttgcagca ggccgtcgac cgcggtgaga tctccagcgc ggccatcagc gatgaactct
1761481 gggacctgct acccggctac ctcatcttcc ggtccatcat ccccaaccgg ccgcccaccc
1761541 aggacacggt gcaagccctc gtcgacgacg tgatactccc cagcctcacc cgatccaccg
1761601 gttgagtcag cggtgcgaat ggctgggcac cgttgtggtg tccggtcccg taccgtactg
1761661 ttgaatccgc ggatccccgc ctgaggtacg gggcgtggtc gcgccccggg caatagcgtc
1761721 gccggttatc gaaaggctaa cgggtgcagg ggatttcagt gactggcctg gtcaaacgcg
1761781 gctggatggt gagatccgtc tttgacacga tcgacggtat cgaccaactc ggcgagcagc
1761841 tggccagcgt gaccgtaacc ttggacaagt tggctgcgat ccagcctcaa ttggtggcgc
1761901 tgctaccaga cgagatcgcc agccagcaga tcaatcggga actggcgctg gctaactacg
1761961 ccaccatgtc cgggatctat gcccagacgg cggccttgat cgaaaacgct gccgccatgg
1762021 gacaagcctt tgacgccgcc aagaacgacg actccttcta tctgccgccg gaggcttttg
1762081 acaacccaga tttccagcgc ggcctgaaat tgttcctgtc ggcagacggt aaggcggctc
1762141 ggatgatcat ctcccatgaa ggcgatcccg ccacccccga aggcatttcg catatcgacg
1762201 cgatcaagca ggcggcccac gaggccgtga agggcactcc catggcgggt gctgggatct
1762261 atctggccgg cacggccgcc accttcaagg acattcaaga cggcgccacc tacgacctcc
1762321 tgatcgccgg aatagccgcg ctgagcttga ttttgctcat catgatgatc attacccgaa
1762381 gcctggttgc ggcgctggtg atcgtgggca cggtggcgct gtcgttgggc gcttcttttg
1762441 gcctgtccgt gctggtgtgg cagcatcttc tcggtatcca gttgtactgg atcgtgctcg
1762501 cgctggccgt catcctgctc ctggccgtgg gatcggacta taacttgctg ctgatttccc
1762561 gattcaagga ggagatcggt gcaggtttga acaccggcat catccgtgcg atggccggca
1762621 ccggcggggt ggtgaccgct gccggcctgg tgttcgccgc cactatgtct tcgttcgtgt
1762681 tcagtgattt gcgggtcctc ggtcagatcg ggaccaccat tggtcttggg ctgctgttcg
1762741 acacgctggt ggtgcgcgcg ttcatgaccc cgtccatcgc ggtgctgctc gggcgctggt
1762801 tctggtggcc gcaacgagtg cgcccgcgcc ctgccagcag gatgcttcgg ccgtacggcc
1762861 cgcggcccgt ggttcgtgaa ttgctgctgc gcgagggcaa cgatgacccg agaactcagg
1762921 tggctaccca ccgttaaggt ggtgggatgc cgctttcagg ggaatatgcg ccgagcccgc
1762981 tcgactggtc gcgcgagcaa gccgacacgt atatgaagtc cggcggaacc gagggcacac
1763041 agctgcaggg aaagccggtc atcctgctca ccaccgtcgg ggcgaagacc ggcaaactcc
1763101 gtaagacccc gctgatgcgc gtcgagcacg acggccagta cgcgatcgtc gcctcgctgg
1763161 gtggggcgcc gaaaaatccg gtctggtacc acaacgtcgt gaagaaccca cgggtcgagc
1763221 tgcaggacgg caccgtgacc ggcgactacg acgcccgcga ggtgttcggt gacgagaagg
1763281 ccatctggtg gcagcgcgcc gtggcggtct ggccggacta tgccagctac cagaccaaga
1763341 cggaccgcca gattccggtg ttcgtgctga ccccggtgcg cgcgggcggc tagccattgg
1763401 gatagggcgg cgtggcacca ttgaccggtg tccgccgaac tgagccagag cccgagcagc
1763461 tcgccgctgt tttcactatc tggggcagac atcgaccgtg ccgccaagcg gatcgcaccg
1763521 gtagtcacgc ccaccccgtt gcaacctagc gatcggttgt cggcgatcac tggcgccacg
1763581 gtctacctca agcgcgaaga cttgcagacg gtgcgctctt ataagctacg cggagcgtac
1763641 aacctgttgg tgcagttgtc cgatgaggaa ctggccgcgg gcgtggtgtg ttcttctgcg
1763701 ggcaaccacg cgcagggctt cgcgtatgcg tgtcgctgtc tgggtgtgca cggccgggtc
1763761 tacgtacctg ccaaaacccc caagcagaag cgtgaccgga tccgctacca cggcggggag
1763821 ttcatcgacc tgatcgtggg tgggtcgacc tatgatctgg ctgcggcggc ggcccttgag
1763881 gacgtggaac gcaccggggc cacgctggta ccgccgtttg acgacctgcg caccatcgcc
1763941 ggccagggca cgatagccgt cgaagtgctt ggccagctcg aggacgagcc ggacctggtg
1764001 gtggtcccgg tgggtggcgg cggctgcatc gcggggatca ccacctacct ggccgagcgg
1764061 acgaccaaca ccgcggtgct gggcgtcgag ccggctggtg cggccgccat gatggccgcg
1764121 ctcgcggcgg gcgagccggt gacgctggac catgtcgacc agttcgtcga cggcgccgcg
1764181 gtgaaccggg cgggcacgct gacctatgcc gcgctagccg ccgccggcga catggtttcg
1764241 ctcaccaccg tcgacgaggg tgcggtgtgc acggcgatgc tcgatctgta tcagaacgag
1764301 ggcatcatcg ccgaaccggc cggtgccctg tcggtcgccg gtctgttgga agccgacatc
1764361 gagcccgggt ccaccgtggt gtgcctgatt tcgggcggca acaacgacgt gtcccgttac
1764421 ggggaggtgt tggagcgctc gctggtccac ctgggcctca agcactattt cctggtcgac
1764481 ttcccgcagg agcccggtgc gctgcgccgg tttctcgacg acgtgctcgg acccaacgac
1764541 gacatcacct tgttcgagta cgtcaagcgc aacaaccggg agaccggtga ggcgctggtg
1764601 ggtatcgagc tgggatcggc cgcggatcta gacggtctgc tggcccggat gcgggcgacc
1764661 gacattcacg tcgaggcgtt ggaaccgggg tcgccggctt accgctatct gctgtagcga
1764721 ggcgtcggcg cgaccgtgcc gacaaacctc gcatgtgtat cgttggtgta tgtcgcgcac
1764781 caacatcgac atcgatgacg aacttgccgc cgaggtcatg cgcaggttcg gtctgaccac
1764841 caagagggcg gcggtcgacc ttgccctacg acggttggtc gggtcgccgt tgagccgtga
1764901 gtttctgctc gggctggaag gcgtcggctg ggaaggcgac ctggatgact tgcgaagcga
1764961 tcgcccagac tgatctcgat gatcctcatc gacacatcgg cctgggtgga gtacttccgt
1765021 gccaccggat caatcgccgc tgtcgaagta cgccggctgc tgtccgaaga agcagcgcga
1765081 atcgctatgt gtgagcccat tgcgatggaa atcttgagtg gcgcgctcga cgacaacacc
1765141 cacacgacgc tagagcggct cgtgaatggc ttgccgtcgt tgaacgttga tgacgcgatt
1765201 gactttcgtg ctgccgcggg tatctatcgc gccgcccggc gcgccggcga aacggttcga
1765261 agcatcaacg actgcctcat agcggcgctc gcgatccgcc acggtgcgcg tatcgtccac
1765321 cgtgacgccg actttgatgt gattgcccgg attaccaacc tgcaggccgc atcgtttcgg
1765381 tgagcatgcc gccccagcat caggccggct ccgcagcccg cagtatcgca agcgaatacg
1765441 ctgctagctc ggtggaatta tcgccgataa tcggcgactc ccaggccagc accagctcac
1765501 cgctgaccgg cacgcaggtt ggctcggcac caaggttgca ggcgatcatc agctggccgc
1765561 ggcgcatcac aacccagcgt tgctgctcgt cgtagtcgac cataaggtgg tccagccagg
1765621 ggtccgcaag gtcggcctcg ttgtgccgca aagcgatcag atcgcgataa aaccggtgca
1765681 acctggcgtg ttcgccggag ccggcttcgg cccagttcag cttgcagcgc tggaatgtct
1765741 gcgggtcctg cgggtccgga atgtcgtccg cggcccagcc atgttcggcg aactcctcct
1765801 tgcgtcctgc cacggtgcta tgggccagtt ccggttcggg atgtgagcaa aagaactgaa
1765861 acgggctgga ggccccccac tcttcgccca tgaaaagcat tgcggtatag ggagatccaa
1765921 gggtcaacgc cgccttgatc gcgagctggc caccggtcag gtattgcgat gggcggtcgc
1765981 cgagagcgcg gttgccgact tggtcgtggg tgcaggtgta ggcgagcagc ctggtggccg
1766041 ggatcgcaga agtgtccaat gcacgcccgt gccgacgacg ccggaacgac gaatacgtgc
1766101 cggcgtggaa gtagccgttg cgcagcgtgt acgcgagagt ggccagcgag ccgaaatccg
1766161 catagtagcc ttgccgctca ccggataccg cggtatggat ggcgtgatgg atgtcgtcat
1766221 tccattgggc ggtgatcccg tagccgccat ggctgggccg ggtgatcagc cgcgggtcgt
1766281 ttcggtcggt ttcggcgatc agcgacaacg gacggcccaa ctggcctgac agccagcggg
1766341 tcgcgttggc aagctcctcg aggacatgca cggcggtggt gtccaccagt gcatgcacgg
1766401 cgtccaaccg caagccgtcg gcgtggaagt cgcgcatcca tcgcagcgcg cagtcgatga
1766461 tatagtggcg aacctcgtcg gagtcggcgc cggcgatatt gatgccgtcc ccccacgggt
1766521 tgctggccga cgacaggtac gggccgaatc gcggcaggta gttgcccgat gggccgagat
1766581 ggttgaacac cgcgtcgatc aacacgccca aacgacgggc atggcatgcg tcgatgaacc
1766641 ggaccagacc gtcggggccg ccgtagggtt cgtgcacgct gtaccacagc acaccgtcat
1766701 atccccaacc gcgggttccg gcaaaggaat tgaccggcat cagctcgacg aagtcgattc
1766761 cgagatcgac caggtaatcc agcttttcga tggcggcgtc gaacgtgcca gccgtggtga
1766821 acgtgccgat gtgcaactcg tagatcaccg cgccctcgac cgaccgcccc ggccagccag
1766881 tgtcggtccg ggcagcacca aactggccgg gcggctccca ccgctgggag cgtgcgtgca
1766941 ccccgtcggg ttggcgggcc gatcgcgggt cgggtagcac ggtggggtcg tcgtcgagta
1767001 ggtatccgta gcgggcgtcc gccggcgccg ccaccgtcgt gtgccaccag ccgtcggctg
1767061 agcgggtcat cgcatgtacc gcaccgttca cgtcgagccg gaccagcgcg ggtttgggtg
1767121 cccatactcg gaattcaggc attgtcgcgc accagcagca ccacaggcag atccgcgaac
1767181 agctcgacgg ccggcgtgtg cccactggcc gtgaatccgg tgagggcatc tgtccacgac
1767241 ccgtcgggta ggggcagtac ggtgtggtcc cagccggttt gctgcaggcg caccgtccag
1767301 cgggtcaccg cgaccaggat gtcgtcaccg cggcggaacg caacgacgtg gtcggcggcc
1767361 ggcccggcgg cgaacaccgg atggtatgcg ccgcccagga agctctccgg atgggtgcgc
1767421 cgcagtcgaa gcgccgcggc caacacccga atcttagggt gctgcaaggc tttcagagcg
1767481 acacgccggg tgccgtagtc gacgggacgg cggttgtccg ggtcgaccag gctgtcgtcc
1767541 cacagttcgc tgccctggta gacgtcgggt acgccaggca cggtcaacgc gagcagctta
1767601 gcggccagcg cgtcgctttc ggcatgcgag ttgaggtggg ccacaagtcc ggtcagctcg
1767661 gacgccagcg gtccgtcgag caccagatca agccagccgt gcacgtcgtc ctcgaacgcc
1767721 cggttcgggt tgtgccacga ggtgtgccat gccgcctccc ggatcgcctt ctcggcgtaa
1767781 gtgtgcagcc ggccgcgcag cgcggcgctg acctctccac tcactggcca cactccgaag
1767841 acgttctgcc acagaaactg tccagtcacg gcatcagggg cgggcgcaat ggcttgggcg
1767901 tggccgatga acttggccca cagccacggc acttgggaca gcacgccgat gcgggcacgc
1767961 acgtcctcgc cgcgtttggt gtcgtgggtg gacagtgtcg tcatggaccg tggccacaac
1768021 cgagcacggg tggcggcccg gtgatgaaac tccgcggcgc ccacaccaaa ccggcgcggt
1768081 tctccgccca cttcattgag tgacaccagc cgggcatcac ggtagaacat acagtcttcg
1768141 acggccttgg cgctcaccgc gccgcacagt tgttgcaggc gtacggctgg ttcgccaccg
1768201 cgggccacag ctgcggcaat cagctgcagt ccaggtgcca attgtggtgt tgtcgaatgg
1768261 gtttcagcca acgcgcaggg taggacggcg gcttggccgg ggtaatcaca gcgatagcgt
1768321 ccgatgtggc gcagcagtgc agccaccgcc gcgggcaaca gcggatgatc ggcgccggcc
1768381 gccgccgcga tgcatcgccg caatcggcga agctcactgg ccaacgtatg gacggccgcg
1768441 tgcaccttga ggtcggccaa catcgccggc atctcctgat agtccacacc ggccgattcg
1768501 accagcgctg tcagtggtga ctctccttgg gggtcaacga ggacgccacc tatttcgcgc
1768561 agcacgtcat agccggtgga gccgtccact ggcagcgtgg gctctaacgc ctcgtcgacc
1768621 gccaggattt tttcgaccac gatccaggcg ttcgggccga gcagttcgcg cagctgggcc
1768681 aagtatccgc tgggatcgga tagtccgtcg aggtggtcga cgcgcacgcc gtcgacgagt
1768741 ccttcggtga accagcgagc gacctctgcg tggctggcgt cgaacacagc gcggtcttcc
1768801 tggcgcaggc cggccaacga ggtgatcgag aagaaacggc ggtagccgca cagcccgtgc
1768861 cgccatccga ccagccgata gtgctggcgg tcgtgcacag cggggccggt gccgtccccg
1768921 ctgccggggg cgacgggcag cgccaggtcg cccagccgca gcaggtcgcc gtcgactctg
1768981 aggttggcaa cgtcgctgtc ggagcccaat agcggcagga tgatccggcc atcacctagc
1769041 tcccagtcga tgtcgaagaa ctcggcatac gccgaggacc ggccgaactt caagacatcc
1769101 caccaccacg cgttctgctc gggcttgccg acgccgacat ggctgggcac gatgtcgacg
1769161 atcaggccca tgccccgcga ccgcgccgcc gcggataacc gcgctaggcc gtcagagcca
1769221 ccaagctcgg gtgacaccgt cgtcggatcg gtgacgtcat agccgtgggt cgacccgccg
1769281 accgccgtca aaatggggga caggtacaga tgcgataccc cgaggtcgtc gaggtagtcc
1769341 agcaggttct cggcatcggc gaaggtgaac ccgaatccgt tcgaccgacc gcgcatctgc
1769401 acccggtaag tggaaataac cggaaatgcc atatttcaca acgtcttacg caggaccagc
1769461 agcgagcgcg caggtaccga aaacgtgtca gtggcggtta ccgtcaggtc gatgtcaccg
1769521 acgggatcgt tggtatccag ctctccggtc cactgctgcg catagccgtc atgcggcatc
1769581 acgaactcca cgtcgtggtc atgggcgttg aagcacaaca ggaatgaatc gtcgactact
1769641 cgctcaccac gggcgtccgg tgcggtaatg gcttcaccgt tgagaaacac cgcaacacac
1769701 ctgtcgaagc ctctgcccca atcctcgtgc gtcatctccc gaccgctcgg tgtcaaccag
1769761 gcgatatcgc ggacttcgtc gccactgcgg atcggttcac cctcaaagaa ccggcgtcgg
1769821 cgaaacacct tgtggttctt gcgcaaggtc gtcgccttgc gtgcgaaagc tagcagatcg
1769881 gcattcttgt ccaccaatga ccaatccatc caagataatt cggagtcctg gcagtagacg
1769941 ttgttgttgc cgtattgggt gcgcccaatc tcgtcgccgt gggcgatcat cggcgtgccc
1770001 tggctgacca taagcgtggc ccacatgttg cgcatctggc gggcacgcag cgccaagatg
1770061 tcggggtcat cggtggggcc ctcgacaccg cagttccacg atcggttgta gctttccccg
1770121 tcgcggttgt tctcgccatt ggcctcgttg tgcttgtcgt tgtacgagac caggtcgttg
1770181 agtgtgaacc cgtcgtgggc ggtgacgaaa ttgatactgg cactgggccg gcggccggtt
1770241 gcttcgtaga ggtccgacga cccggtcagc cgggaggcga attcgcctag ggtggccggc
1770301 tcgcctcgcc agtagtcgcg cacggtgtcg cggtacttgc cgttccattc cgtccacagt
1770361 cctgggaagt tgccaacctg gtagccacct tcgccgacat cccatggctc ggcgatcagc
1770421 ttgacctgac tgaccaccgg atcttgttgc accagatcga agaatgccga cagccggtcg
1770481 acgtcgtgca gctcgcgggc cagcgtggac gccaggtcga accggaaccc gtcgacgtgc
1770541 atttcgatca cccagtagcg cagcgaatcc atgatcagct gcagggtgtg tgggtggcgg
1770601 gcattgaggc tgttgccggt accggtgaag tccttgtaga acctcaagtc gtggtccatc
1770661 agtcggtagt aggcggtgtt gtcgattccg cgaaagttga tcgtcggacc caagtggttg
1770721 ccttcagcgg tgtggttgta gacgacgtcg aggatgacct cgatgccggc ttcgtgcagg
1770781 ctgcgcacca tggttttgaa ctcggctacc gcgctgccgg cttgccgggt cgacgcgtat
1770841 tgatggtgcg gggcgaagaa tccgaaggtg ttgtaacccc agtagtttcg caagccgagg
1770901 tccagcagcc gggagtcgtg taggaactgg tgcaccggca tcaactcaac ggcggtgacg
1770961 ttgagctcgt tgaggtggtc gatgatcacc gggtgggcca ggccggcgta ggtgccccgg
1771021 agttcgggcg ggatactggg atgggtctgt gtcatgcctt tgacatgcgc ttcgtagatt
1771081 acggtctcgt ggtacggggt gcgcggcgac cggtcgtatg cccagtcgaa gaacggattg
1771141 atcacgacgc tggtcatagt gtggcccagc gagtcgacca tcgggggagt gctgtccggg
1771201 tcgacggcgt tgacgtcata ggaatacagc gcctgcccga aggtgaaatc gccgtggaac
1771261 gacttcccat acgggtcgag cagcagcttg ctggggtcac accgatggcc ggccgccggg
1771321 tcgaacggcc cgtgcacacg aaacccgtag cgctggccgg gggtgatgtt cggcagatag
1771381 gcatgccaga cgtacccgtc cacctcgtca agcgggatcc gcgactcgac gccgtcctcg
1771441 tcgatcagac atagctcgac cttctcggcg atctcggaga acaacgaaaa gttggtcccg
1771501 gcgccgtcgt aggtggctcc aagcggatag gcgttgcccg gccacaccgt gggtagagcg
1771561 ggcccggtcc cgtcggactc cccggcgttg ttcgacgaca tcacacgacc ttatccaggt
1771621 tctccggcgg gtgtaggcgt caccaccagt cggtgttcgc cgcgatttgc cgaccgagct
1771681 cgctggtcat cgtccgcatg taggtggggg tcaggtgatg actgtcgcgg tacaccagaa
1771741 catttccctc gaccgcgcgg caggtgtcgg tccggcatat cgcgtcggac atatcgagtg
1771801 gcttaagcag cgggaaccgc gcaacgaagt cgagggttgg attccgatcg accagcacct
1771861 tggaccgcgc gatcccacac gactgcggat tgccgccttt ggccaggcag tccgcaggga
1771921 tgaacggttg gccgtccttg accagccaag gggtatcccg catcgcgaga acgggaatgt
1771981 tgttgtcggc gaacgtttgc cagatcccga cataggttgc tggcatcaca tcgccgggtt
1772041 tgatgttcca cggtcgagtc gaggttgtga aaacgtagtc ggggtggtca gcgaccaact
1772101 tggccatcgc cgcttgcacc cactggtgac actgcggata gggagcgtta ttgcccatga
1772161 tcagcgggac ttcctcggtg gacaacgggc aacccatttt gaggtacgtc accaccttga
1772221 agtggtgcat gcgacccagc agatccagtg cggtcagcca gtgttcggcg tgtgaacccc
1772281 cggccagtgc gatggtccgg ggtgcgtcca catcgccgta ggtgcagttg atgatcgccg
1772341 ggttgacgaa gtcgctgatg cagccgtcct tggtcgaggt cggcaggtcg tgacggactt
1772401 ccaggacggt tgggcgcatc cgcagcttgg gcacccggac gtggtcgatc agggcccgcg
1772461 ccccgggata gtcgcgggag ctcaacccgc tcaactcttt gccggcggcg cgctggacga
1772521 tgacgtgctc acgccacgtg aacgaggtcg cggtaagagc gacgccaagc agtgccacca
1772581 cagatcccag cacgatcgtt ggccgacgca gccgcagccg ccagggaatc ggcgggaccg
1772641 ccgccggcga tctcacgccg gcgggtgccc gatagcgtaa tgggtcttcg acaagccggg
1772701 tggtcaggta tgccagcaac ccggatacca gcaggactgc cgcgccttcg acaaagttgg
1772761 cgtgccggtg cccggtgtag gagagccaga agatgagcag cggccaatgc cacagatacc
1772821 aggaataggc catcgcgccc agcgccacca acggagcggt ggctagcagg cgattgggca
1772881 gtggcagccg gtcgcgggta ccgggatggc cctgccggtt ggctccggca aggatcatca
1772941 gcatcgtggc tccgacgggt accagcgccc acggccctgg aaattccttg acaccgtcga
1773001 tcagggcgcc gcacgacagt atcgccgcca gcgcggcggt ggccaccgcg gtgcgcagcc
1773061 acatcggcca gcgcacatgg ggcaccacag cgccgaccag tgctcccgcc aacaactccc
1773121 aggcccgcgc gaaggtgttg tagtaagcgg tcgcctggta ggcgtgatgc gcaacgatgg
1773181 catagatgaa tgaggccaac gtcaacgtgc tcaataacac cacaaacatc gtccgcaggt
1773241 acggggcccg cgggccccga aacagtctgc gcagcaagta ggcgcacccg gcaacaagca
1773301 gcaggaaagc gagatagaac tgaccctgca ccgacataga ccagatgtgc tgcaaggggc
1773361 tcaccgcttc accggctcgc agatagttgg agaccgtgct agccagctcc caattctggt
1773421 aataccccaa gctggccagg ctctggttgg caaacgcttc ccaccgcgtc tgcggttgta
1773481 ttgcgatggt gagcagcgcg cagccggcga ggaccacaac cagtgccggg agcagccggc
1773541 ggatgagtcg gatcacttcg gctataggcg agagtgacag atccgggttg agggcggcgc
1773601 gaagtatttt cccgccaaag aagaagccgg acagcgccag gaacacgtct actccgccgg
1773661 aaacccggcc gaaccaaacg tggaacactg ccaccagggc gatcgcgaca ccgcgcaatc
1773721 cgtccaggtc gtgccggtaa aagccggtcg tacgggtccc catggtaacc gggggcaagg
1773781 ccggctccgg ggtcaaggcc ggtgggcgag gcggcgacag ggtcaacatg gttgacagtt
1773841 aatttaccca aaccagcctc ctgcttcgcg cgctgagcag cgggaagcag gaggcgggtt
1773901 tgggaggcga gaaagcaagc gggaccgtta gcgtgagcgc gcggtgccga agggaggcgg
1773961 ctggacgggc gcttgctgga cgggcgcttg ctggaccggc gcctgttgga ccggcgcctg
1774021 ttggacgggc gcctgttgga cgggcgcttg ctggacgggc gcttgctgga ccggcgctgg
1774081 ctggaccggc gcctgttgga cgggcgtcgg ctgggtcccg agaacccgga ccaggtaagg
1774141 cgtcatgccg ttggtgcgca ccggcgaaac ctggacgacg tcgcccacct ccagcatctg
1774201 gcccttcccg aggtataacg cgacgctttg cgtgccttcg gggccgtaga agatcaggtc
1774261 gcccttgcgc gcttgctgcg gcaggacctt ttgcccaacc ttgtacatct ggccggaaga
1774321 acgcggcagc tttagcccgg caccggcata ggcgtactgg atcaaaccgg aggcgtcgaa
1774381 cccgacggtg ttgatgccgg taccggtgcc gcgcgtgggg ccgctgatgc cgccgccggc
1774441 ccaggagaac ggcacgccgc gctgcgacag cccgcgcgcg atcacgacgt cggtgatctg
1774501 ttgataatcc accggccgcg tggccgggtc tgcggccgca agaccgggcg cggccaccat
1774561 cggggcgagc atcattgcca gaccgatcgc gaaggagccg cttttcatgc tgcgtttcat
1774621 ggggttgtaa cctccttggc actctcgggt ggtgtgtgcc tcagcacgtg acttcaccgt
1774681 ctgccattcc agccggaagt cactttattc acaccaatca ctacagacac tttgacaaca
1774741 gatgccggcc gcgtccatag ctggccagat ccaccagaag tctttttgcc gtaacgtgac
1774801 cggacggtga ctgccgcgct caatctttga tcggcagttg tgatttcagt cacgcgcgat
1774861 taatgccaat agcgttcgct gaatcccgct atcgcgtagc ccgcgatgga ggtgacggtg
1774921 atgacggcga tcgagatgat cggccagaag gacatgtacc agcccttcaa catggaaacg
1774981 aaggggccga tgacggctgt ggcgatggcc gcaccgatcc ctccccacat caccgggtag
1775041 atgtaatagt tgacgccgaa cggtaccagc gggcaagcat ccggcgggca cacgttgtcg
1775101 gtgaaggcga agagccgtga tggccagcta gtcatcgtga ccatgaccag aaatactgcc
1775161 aatatcgcta cggtacatac cacgtcccag ggcgctatcc gcagcgtgag tacccgtggg
1775221 ggtgtccgct cgtcgggctc gtctagagcc gaccgggatt cggtgccagc atcgggctga
1775281 gtgtcttcag gctgattcgg cggtgccatg catgcatgct ccccgatggc agaggttttg
1775341 gcgaccgtta ctgggatggg ccgtggcgtg gctgcattac cctcgatctc catggctgcg
1775401 gcgactggcg ggttgacgcc cgagcagatc atcgcggtcg atggcgccca tctgtggcac
1775461 ccttacagct ccatcggcag ggaagccgtg tcgccggtgg tggccgtcgc cgcccacgga
1775521 gcgtggttga cgctgattcg cgacggccag ccgatcgagg tgctcgacgc gatgagctcc
1775581 tggtggaccg cgatccacgg gcacggccac cccgctctgg accaggcgtt aaccacccag
1775641 ttgcgggtga tgaaccacgt catgttcggg gggctgactc acgagccggc ggcccggctg
1775701 gcgaagctgc tggtcgacat caccccggcg ggtctcgaca cggtgttctt cagcgactcc
1775761 ggctcggtgt cggtggaagt cgcggccaag atggcgctgc agtactggcg cggccgcggc
1775821 ctgcccggca agcgacggct catgacctgg cgcggcggct atcacggcga caccttcctg
1775881 gctatgagca tctgcgaccc gcacggcggc atgcactcgc tgtggaccga cgtcctggcc
1775941 gcccaagtgt tcgcgccaca agtgccacgg gactacgatc ccgcctacag cgcggcgttc
1776001 gaggcgcagc tggcgcagca cgccggcgag ctggccgcgg tggtcgtgga gccggtcgtg
1776061 cagggtgcgg gcggtatgcg ttttcacgac ccgcgctatc tgcacgacct gcgggacatc
1776121 tgccgccgtt acgaggtgct gctgatcttc gatgagatcg ccaccggctt cggccgcacc
1776181 ggcgcgttgt tcgccgccga ccacgccggg gtgagcccgg acatcatgtg tgtcggcaag
1776241 gcgctcaccg gcggctacct cagcttggcc gccaccttgt gcaccgccga cgtcgcgcac
1776301 accatcagcg ccggtgcggc cggggcgctg atgcacggcc ccaccttcat ggccaatccg
1776361 ctggcctgtg cggtctcggt ggccagtgtg gagctgctgc tcggccagga ctggcgcacg
1776421 cgcatcaccg aactggccgc cgggctgacc gccggcctgg ataccgcccg ggcgctgccc
1776481 gccgtcaccg atgtgcgggt gtgcggcgcg atcggcgtca tcgaatgcga ccgaccggtc
1776541 gacctggccg tcgcgactcc cgcggcgctg gatcgaggcg tgtggctgcg cccgtttcgc
1776601 aacctggtct acgccatgcc gccctatatc tgcacaccgg ccgagatcac gcagatcacc
1776661 tcggcgatgg tcgaggtcgc acggctcgta ggctcactgc catgaaagcc gccacgcagg
1776721 cacggatcga cgattcaccg ttggcctggt tggacgcggt gcagcggcag cgccacgagg
1776781 ccggactgcg gcgctgcctg cggccgcgtc ccgcggtcgc caccgagctg gacttggcct
1776841 ccaacgacta tctcggtctg tcccgacatc ccgccgtcat cgacggcggc gtccaggcgc
1776901 tgcggatctg gggcgccggc gccaccgggt cgcgcctggt taccggcgac accaagctgc
1776961 accagcaatt cgaggccgag ctcgccgagt tcgtcggcgc tgccgcggga ttgctgttct
1777021 cctctggcta cacggccaac ctgggcgccg tggtcggcct gtccggcccg ggttccctgc
1777081 tggtgtccga cgcccgttcg catgcgtcgt tggtggatgc ctgtcggctg tcgcgggcgc
1777141 gggttgtggt gacgccgcac cgcgacgtcg acgccgtgga cgccgcgctg cgatcgcgcg
1777201 acgagcagcg cgccgtcgtc gtcaccgact cggtgttcag cgccgacggc tcgctggcgc
1777261 cggttcggga gttgcttgag gtctgccggc gtcatggtgc gctgcttctg gtggacgagg
1777321 cgcacggcct gggtgtgcgt ggcggcggac gcgggctgct ctacgagtta ggtctagcgg
1777381 gtgcgcccga cgtggtgatg accaccacgc tgtccaaggc gctgggcagc cagggtggtg
1777441 tggtgctcgg gccgacgccg gtgcgggccc atctgatcga tgctgcccgg ccgttcatct
1777501 tcgacaccgg tctggcgccg gcggcggtgg gtgccgcacg ggccgcgctg cgcgtcttgc
1777561 aggccgagcc gtggcgaccg caggcggtgc tcaaccacgc tggtgaactt gcgcggatgt
1777621 gcggtgtggc tgcggtgccg gactcggcga tggtgtcggt gatcctgggc gagccggagt
1777681 cggcagtggc cgccgcggcg gcctgcctgg acgccggggt caaggtgggc tgcttccggc
1777741 cgccgacggt gcccgcgggt acgtcgcggc tgcggctgac cgcgcgcgca tcgctgaacg
1777801 ccggcgagct cgagctggcc cggcgggtgc tgacggatgt tctcgccgtg gcgcgccgtt
1777861 gacgatcctg gtcgtcaccg ggaccggcac gggggtcggc aagacggtcg tctgcgcggc
1777921 gctggcgtcg gccgcacgtc aggccggcat cgacgtggcg gtgtgcaagc ccgttcagac
1777981 cggcaccgcc cgcggtgacg acgacctcgc cgaggtcggc cggttggccg gggtgaccca
1778041 gctggccggc ttggcgcgat atccgcagcc gatggccccg gccgccgccg ccgaacacgc
1778101 cgggatggcg ttgcccgccc gcgatcagat cgtgcggctg atcgcagacc tggaccgtcc
1778161 cgggcggttg accctcgtcg agggggcggg cgggctgctg gtcgaactcg ccgagccggg
1778221 cgtcacgctg cgcgatgtcg ccgtcgacgt ggccgccgcg gctttggtgg tggtcaccgc
1778281 ggacctgggc accctcaacc acaccaagtt gacgttggaa gcgcttgctg cacaacaggt
1778341 ttcatgtgca gggctggtga tcggcagctg gccggacccg cccgggttgg tggcagcctc
1778401 gaatcggtcc gcgctggcgc gcattgctat ggtgcgggcc gctctgcccg ccggggccgc
1778461 gtcgctggat gccggggact tcgcggcgat gagcgcggcg gcgttcgacc gcaactgggt
1778521 tgccgggctg gtcggctgat ggtgcattcg atcgagctgg tcttcgacag cgataccgag
1778581 gcggcgatcc ggcgcatctg ggcggggttg gccgccgccg gcatacccag ccaggcgccg
1778641 gccagccgtc cgcacgtgtc gctggcggtg gccgaacgga tcgccccgga ggtcgatgag
1778701 ccgctgggtg cggttgcccg tcggctgccg ctggactgcg tgatcggcgc gccggtgctg
1778761 ttcgggcggg ccaatgtcgt gttcacccgg ctggtggtgc cgaccagcga gcttttggcc
1778821 ctgcatgccg aggtgcaccg gctctgcggc ccgcacctgg cgcccgcgcc gatggccaac
1778881 agcctgcccg gtcagtggac cgcccatgtc accctggccc gacgggtcgg tggtcaccaa
1778941 ttggggcggg cgctgcgcat tgcgggacgg ccgtcgcgga ttgacggtcg gttcgccggc
1779001 ttgcgccgct gggacggcaa cacgcgtgcc gagtacctgc tggggtgagg cgggcccaaa
1779061 aagcttgatg gcgaaggggt ttgatcgcaa cttcgtctta atggccagct cgcgggttcg
1779121 ggcgggtgct ggccaggtgg cgaggacgca cgtcgatgtg gggatgtcca aagatcttcg
1779181 cgggcggcga ttctcacgga tcgtcgtggt tgtcctcgtc gttgtggcgt agcagcttct
1779241 cgtggtggtg gaaggtgttg gtgcggggtt ggccgtggac tgctgaagaa cattccacgc
1779301 caggagatca accatgacca ccacaccagc acgtttcaac cacttggtga cggtaaccga
1779361 cctggaaacg ggtgaccgcg ccgtctgcga ccgcgaccag gtggccgaga cgatccgggc
1779421 gtggttcccg gacgcgccct tggaggtgag ggaagcgctc gttcggctgc aggccgcgtt
1779481 gaatcggcac gagcacaccg gcgagctcga agcgttcctg cggatcagcg tcgagcacgc
1779541 cgacgccgcc ggcggcgacg agtgcggccc ggcgatcctg gccggccgct ccgggccgga
1779601 acaagccgcc atcaaccggc aactcggact cgccggcgac gacgagcccg acggcgacga
1779661 caccccgccg tggagccgga tgatcgggct tggcggcgga agcccagcgg aagacgagcg
1779721 ctgacggtga acaccgcggc aacaggacgc tgggcggtcc cacgggcggg gcatggatag
1779781 cttccggccc atgggccgga agctatctcg gagaaacaaa tggcgccgct ggccgccgga
1779841 tcgcggagct ggagcggccg aaagccaagc agcggcagcg cgaggggcag gatcatggcc
1779901 gccaggctcg atattctggt ttggggccca tgggctacaa accagaatca gagcgtcatt
1779961 cgacgaaaac agacactgct atcggcgcag ccctcggcat ctccgccggc acctaccggc
1780021 ggctcaaacg aatcgacaac gcaacccaca gcgacgacaa agaaatccgc cggttcgcgg
1780081 agaaacaaat ggcgccgctg gtcgccggat cgccgagctg gaacgcccga aagccaagga
1780141 gcgccaacgc gagggtggtc gcctcggtgc atcgatcacc aatgccggct ttggtcccat
1780201 ggaaccaaag ccgtctcagc gccacactga caaggaggta ggcgcagccc tcggcatctc
1780261 cgccggcacc tacaagcggc tcaaacgaat cgacaacgca acccgcagcg acgacaaaga
1780321 aatccgcctg ttcgcggaga aacaaatggc gccgctggcc gccggatcgc cgagctggaa
1780381 cggccgaaag ccaagcagcg gcaacaggaa ggcggcgacc atggccgcca ggctcgatat
1780441 tctggcttgg ggcccatggg ccccaagcca gaatcggagc gtcgttcgac gaaaacagac
1780501 actgctatcg gcgcagccct cggcatctcc gccggcacct accggcggct caaacgaatc
1780561 gacaacgcaa cccgcagcga gttggcgcgt gggcggcccg gcacccctaa gcagaggccg
1780621 cccacgcctg gccctatcct acctacgcgg tagtctccac cttcagaact cgaaacgcgt
1780681 tgcgcaccag cacatctgat ccgaccctga accaggcgaa gaatccgcgc tgcccggtcg
1780741 gccggcgatt cggcccgaac aggtgaggca ccaactccac catggaccca actctgtcgc
1780801 cgatgaggaa ttgcttccag tcgccaagca ccagtggatg attcgtcgct gtcaccgccg
1780861 aatcaacggt gtccatgtgg gagacttcca ggacagactt cccggctagc atcggcggac
1780921 tgtcgtgcag cgatgggaat ttcagcgcgc cattcgaagt ttccgcctgc cgcaacgtgt
1780981 tgatggtgga caagttcgcc gcgaacgcgg cgctggcctg gaaccttggc ggcagcgccg
1781041 actgcaacgc gtaaacatcc gccgccacaa tcgcttctga ccccgcgccg acgaccacct
1781101 gatcggaggt gccggttagc gcgctgacga acccggtggg ctcgccgttg ccggagccgt
1781161 tgacgaacgc cgcggcctgc agttgctcaa cgctgtccgc gagaatcttg ccgatctcgc
1781221 caacgaagct cgccgcgtca ccctccagct cgatggagaa cggaatccag cagcttccac
1781281 ggtagttcgg caccgccggc tgggccaacg ctggcgaatc gtcggacacc tcctgggctt
1781341 cggagtacca acgagcttcg gcgccttcgg aagtcacgcc ccgccaaatc tcggaggtcg
1781401 tttgcaccac cctcgccacc tgccgaatcg ggttcgtcga cccatcaccc gacagcagga
1781461 tcgccgggtc cagcgccgcc gggatcagaa acccgccttg ggtgtccacc aggcccatcg
1781521 ctcgctgctc ggcggccacc gcggcagcct cacgccacgc ggccgcttcc cggtcggtcc
1781581 aaaccgtgtg ccccgcaaca ggattggaaa cccgcttgac gaacgcgccc aaatagtcgc
1781641 ggctgccggt ggccgccagc cagcgctgcg cccacgaggt ggactgcggc ggcccggtgc
1781701 ggcacaaggt ttccgcggtc tccgccgccc gcgacgacat caggccgtct cgcacacaag
1781761 aatccagtgt gcgaaacgcg gtgtcccgca acgagttgcc cggcggcgcg tcgccgtcgt
1781821 cgccgccggt gggagcgccg ggcaccaccc tcagctcacc ggcccggtag cggcgcagcg
1781881 cctcctcggc ttcgcggccg cggcggcgct gctccgcccg cagttcctcg gcgtggcgcg
1781941 tcagcgcctg aaaacgctgc gccgcctcac cggtcaggtc gccggcgaca ctgtcgagga
1782001 gctgcttcgc cgcgtcacgg gtttcaggta aagagaggtt tttgatgtcg tcgaattcgg
1782061 tcatagattg ttcaccaatc gagtagggac agccaggctt cggctgtcga acgggaaacg
1782121 actgtaagcg attccgcgcg caccccggcg atttgtgccc ccgaataggc cggaacgccg
1782181 gttagggaaa cctctaacag cgccgcttcg acgcgcacca gcacatcccc ttcgcgacgg
1782241 tcccggatcg gtcggaaacc caccgaaaac gagtcgacga caccagcttt tacgttcgcc
1782301 aaagcctcgt cgccgtccgg ggtgtccgca atctcgaacg ccccgaacaa gccgtgaggc
1782361 tcctcccgca actcaacggc ccggcccacc gggtagcggg ttcgagcgtc gtgagagacc
1782421 agcagcttca atttgtggcc gcgctcggcg atggagcgcc gaaaagcgcc aggagcgaac
1782481 atttcctgga actcgccgtc gaagtcgcgg acggtggtcg cctcgttgta gggcacgatg
1782541 gtgccgtgca cggttcggcc ttcgccagac cgcagctcgg ccatgcggaa aaggatgcta
1782601 ctcaaaattc ggccaccacc tagcagacgc aagaaacgcg cggaatcgct tgtggcgcat
1782661 ggcggccgct atccgggttc cagccgcccc gcggcgactg cccggcgtca gcggatgccg
1782721 agatgccaaa ctcgattgta tcacacacaa aaggtcatca ccggtccggg gcaaacgggt
1782781 tgagcccgtc gccgtcgtcg cccggcgcca ccgccagtcg ctgctcggcg gccggggtca
1782841 ggccaaactc ggaggccaag cgcagcagat gcatgcgcgc cgtctccgca accgtcaccg
1782901 ccgggttccg gtgcacgaca ccggatttcg gtgaggtaat tgtgaggcct tcggcgcgga
1782961 cccgctgaac cgccgcgacg tagacggacc aggtctcgca gtacgcggac aggagcgccc
1783021 gatcctcagg tttgagcagg tcaagccgct ccaaagtcgg tgcgacgcgc cgccattcgg
1783081 ccagcgcctc ggcgtcgagc cagtccgggg catccggtgc ctgacggata aacttcggcg
1783141 actcggggac tttccggccg ccggaatcgc ggccggggga gcggccctca accagtttga
1783201 gccgggccgg tttcggtggt cttggcatcg gtcctcccat caatttttag tctaggtaat
1783261 gagcgtgcat gcgcgccggc accgtggcgg tgtccgggct gggcctggtc acgatggcga
1783321 ccccgccccc tggtcgtcgt cctgctcgat aggtcgggcg tctcgcagcg ggtcgttgcc
1783381 gggatacgac gcgtggaagg caagccagtc acgatcggca tggacaagaa cattgcctcc
1783441 ggcttcgagg taggcgttct cggtgtcgcc gcggaggata agtgttccgt ctttcgcgaa
1783501 ggattcgagt gcttcgaccg ccgcatcggg tgagcaaccc gtctgcgagc agacaacctg
1783561 gactgccagc tcgtgcatca gttgtcgttc gtcgttggtc aggggccggt tgatcggggt
1783621 cactggtcga cctctatggt gtcgtcggtg ctgtcggcga caccctcggc gattaggaac
1783681 gggcacggct taccgacgtc gacgggacag ttcgcgcgct tccatttgtt gtcggcgaca
1783741 cccatgacgg gttcgccggt ctgcaggttc ggcaggatga tgtacggcac ggcgtcacca
1783801 cagcgtttgc aggtcgccat accgacatcg gcgttgaaag ccatgtcggc gattcgtcgc
1783861 cgcagttcgg cgtggtcggg ggtttcagcc atggcttgtg tcctttcaag cagggttggt
1783921 aagtgcggtt ctggcggcat tgagctgctg ttgcagtatc gggcatccgg ttggggcgtc
1783981 ggggtgcagc actttggata aagccctgta cacggcgggt gtccgctggg gtccgaccgc
1784041 ccggaacaac gctttggccc agtcggtgca ctgctgttgc gccgggtcgg cgggtccggt
1784101 gacggtgtgg ccgtggtagc gcagctcggc ggccagcagt ggggtccagt cagcgtcgat
1784161 gaaccagcag cgggtgtgcg cggaccagga gcgggcatag gcggggatcg tggacttgat
1784221 caacgacacg atcgcagagt cgtaggcgaa tcggacgctg tgccgaccgc cggatgccgg
1784281 ggtgatcgcg acagcggtca tgcggcaccg ccggtgtttg ctggtttggc ggtacagtcc
1784341 gcccggtggc ggccgtgaac ggccaggtag gtaccgcatc ctgggcagaa cggcacggca
1784401 ggccgtgacg catgtgacgt ttgcgcggta taaccgccat acgtgcgcgc gcgtaggcga
1784461 acctggaaat gcgtcacatg cgtcacgtta ggtgtgctaa tcatcgaaat catcggcccc
1784521 tctcaccgct attccggccc gccaacgacc atcacgggcc ttgtcagtga ccgggtatcc
1784581 gtgggtgtcg agcgactggc cgaacgcttt gcgcgagatt tcgggtacgc cttcttgcac
1784641 ccgccacctt tgccacgcct cgaacagatg cgtagtagtg gctttcagca ccggcgagct
1784701 ggtgacgcat tcgtcgtcga tgaacctctt tatcgtgtcg gagtcctcgc ggtaattcga
1784761 cgttgccgcg agcaccgcgt ccggctggga tagtccgatt cgctgatagt cgctccatcc
1784821 ggccaccgcc caggacagga tgctgtcggc ctccaactgc aaccgtgcgt ccagttcccg
1784881 gtcctgctcg tcggcaggaa tcactacttc aaacggcacc actcgaattc gccgccagat
1784941 ggccgtatca tcgccgggca ctctcggtag gtggttggtg atgagcagtg gggtatgtga
1785001 cggcgtgaat tccacgaagt cttgccgcat ctttcgggcg cggatggtgt cgccgccagt
1785061 cagccgtttt atcgttgatt cggccagccg gcgatctttt tcgctctcgg ataccgctac
1785121 ccatcgcacg ccgcggaggt ccatttcgcc tgttgggtga gcgttttccc ggtgcatgaa
1785181 aaggtcaggc tcagcggtgc aggcataatc gccaagggca tagcgaatcg ccttgtcgaa
1785241 cacagatttt ccgttggcac ctacaccgat aagaatcgcc aggacatgtt cgcggacggt
1785301 gcctagtagg ccgacgccgg ccaggcgttg cacgaacccg cgcacacctt catcgggcag
1785361 aacgcgggtc aagaacgctt gccagagagg cgattcggtg tcggactggt aggcaccgcg
1785421 gcatatcttt gtgatgcggt cagcgggcgc gtggggccgc aatttgagcg tgtgcaggtc
1785481 cagcgtccca ttcgcgacgt tgagcaagtg cgggtcgctg tcgaggtcgg ctaccgtcgc
1785541 ggcgaatggt accagtgcgg cggccaggtc gagcacgccg gccacgccgg acgccgattc
1785601 gcattttcgg acgtcggcgc gtaattcctt gtcgttgagg ctgtctgaga gcgcttggcg
1785661 cagctctgcc agcactgcac gtttggcttc gccgcggtcg tcggctgccc agcgtctgcc
1785721 gtcccaggag tgccagccga tcccggccac gtgcagcagc ttgtcctggt aacgttcggc
1785781 tagccggtag gcgattcggg cttggccgcg atgaacttgc gtcggtttgc caccgtcgtc
1785841 gatgagcacg tgcccgtccc ggtcgatcca gggggcgtcg ggatagtcgg tgccgtaggg
1785901 gatgtcggcc atcacgccac ccccgcccgc gggatgtaca cgccgcgccg tcggacgatc
1785961 tcgcgggcga tgccgggcca gtcggcggcc gcagatacgt cacgtgacgc ctgcgccatc
1786021 gcctcctggc acgtctctac cctcagagcc cagtgccggg ctgcgtcgca gatcgcggcc
1786081 catttgcgag gatcggcgtc gtcgagctga cgccaggccg gtgtgccggc catcggccac
1786141 gacccggcag catccaggac cggcgcgaca tgctcgtgca ccgaccacca cgacacggcg
1786201 cgtgacgcgg taggatcggc gctagacggt gtggcgactg tcgcgggtgc ccggtcctcc
1786261 gtggccgggc atcgtcgcgt cggcggcgac ccgccggcgc cggcggtcat cgggcaccgc
1786321 ctgaccgccg cacggggcgc agcagctcgg ccagccgggt gcgctgctcg tcagtcaggg
1786381 gcggcgctgc ggcgagggtg cggatgaggt agtccgcgat gttcgcggca acgagatcgg
1786441 ttttcgcggc gatgaactcg ggatcgtcgg atgcgcggga acgagacagt gcggctacgc
1786501 ggccgcgatg atggtagatg gtcgacacgt gcgactcctt ggggacacca aaaccccgga
1786561 gtcgaagccg gctacgtcgg agtctagcag ctaccacgcg ttggggtggc gcgtagtttg
1786621 ttcggcgtgt cgctttcgca gagcgtgcgc cacagccaca tggcgacgac caccgcgtcc
1786681 gactgcaccg caaaacccgg tgcgtagtcg gggttgccgg ccagtccggt cagtagccgc
1786741 ggaacgttct cgcacagtgt ttgcaggtcg ccgttgcgaa cccgcacggg ccgctgctcg
1786801 cacgtgcgca cgccggcggc gccgtacctc aggcaggcga attcccagtg cagccgcacc
1786861 cacccgtcgc ggcgcatttc aggtcgtagg cgagactcgt tgggcggcaa gccaataacg
1786921 gctcgcggct ggttgtcgtc gtcgagtaat gttgccaccg ctggcgcctg cggtaaccag
1786981 ccctgggtct cgtcgaccca aatgatcggc gcgacaagat cgcagcgctc gtgttcgatg
1787041 cggccatcgc ctttgcggcc gtggtcacag acgatcacga tgttgtggtg ccggctcatc
1787101 gccaattcac ctgcacccgt tcgggattga atatcctgcc gctcttgccg accggctgga
1787161 caacgacttc agcgaggacg tcgaggacgg cgcggaaccg gtccggcgac agctcggcta
1787221 tcatcccggc gacttgcggt gttcccaacg gtatcccgtc gaacactcgg agccgttcct
1787281 gatcctgttg gcgggcctga agtttcgtta tcttggcgtt gacgatgtcg gtgctgatct
1787341 tcacctggcg cgcggtcagt agcccttcgg cgcgttcgac ggcgagcctg tccagctccc
1787401 cgtagagggt ttccagttcc aggcggatgg tttcggcttc ggcggcgtcg tgaatctccc
1787461 ggcgcaacaa gtcaacggcg tcgggcatgg ccagccgctc ggccacgatg tgatacagga
1787521 tcggttcgat gttgtcggcc aggatggcca ccccgtggca cgccttgcac acgtagacga
1787581 cctggccgtc ggtgcggtag ctgccggcca ggtggttgcc gcatttgccg cagcctgcca
1787641 gcccggtcag caggtggcgg cgcacgcttt tgcggccggg ggcgcggccg ggggcgtcca
1787701 gcacggcctg ggcggcccag aacgtcgcct cgtccaccag cggcgaccac tgggccttgc
1787761 cgacaatcgc gtcgcggtcc accgggccgt agcgggcacc cttatatgcg cgtagtccgg
1787821 cgttgcgggg tttgcgcaag aatttcgaca gcgttgtagt cgtccacggg cggccggtga
1787881 tggtgaacgc cccggcgtcg ttccactggc ggcacacgtc gcccagggac gccccggcga
1787941 ggatgtcggc gtaggcctgt ttgaccagcg gcgctgtccg ggggtcgggt tcgggaccgt
1788001 tggggccggg caggtagccg aaggctttcg accagttggg gtggccgcgt tcagctttct
1788061 ggcgggcggc gcggcgctgt cgtgccttct tgtgctcggt ttcgtgagcg gccaccgacc
1788121 ccttcaggcg ggcgactagc cggccctggg gtgtcgccag gtcaacgtcg ccggcgacgg
1788181 tggccagggc cagccgcttc tcgtcggcta atgacatgaa ggcttccagc tcgatgggac
1788241 ggcgatggag ccggtccagg tcccaggcca ccacggcggc gatcttgccg gcggtgatgt
1788301 cggccaacat ctgctcgtag gcggggcggc gcttgccggt tgatgcgctg acgtcgttgt
1788361 cgaggtactc gacgggcacc cattttcgct gcccgcacag ctttaggcag tcctcgcgtt
1788421 ggcgggccac gccgagctgt tcgccggagc ggtcttctga gattcggagg tagacagcag
1788481 cacgcacagg tgtagtgtat ctcacaggtc cacggttggc cgtggtcgag gtggggtggt
1788541 ggtagccatt cggtgtggcc gtgggtgttg ttgtgggtgg tccagccttt ttcggcgagt
1788601 cggttgtcgg ggccgcaggc cagggtcagc tcggtgatgt cggtgcgtcc ggtgctggtc
1788661 caggcggtga cgtggtgggc ttggctgtgg taggccggtg cgtcacagcc gggtttggtg
1788721 cagccgcggt cgttggcgaa cagcatgatc cgctgggccg gggaggctag gcgtttggtg
1788781 tgatacagcg ccaggggtgt gccgtggtcg aagatcgcct gggggtacct cccgcttgcg
1788841 ggggagtagt ggtgggcgtg gctggtcatg cggatcacat cggccatggg tagcagggtg
1788901 ccgccgccgg tgaagccctt gccggcgccg gtttgcaggt cggtcagggt ggtggtgacc
1788961 acgatcgaga cgggaagacc gttgtgttgg cccagtttcc cggaggcgat cagcgcgcgc
1789021 agcccggcca gcagcccgtc gtggttgcgt tgggcttggc tgcgggtgtc gcggtcgatg
1789081 gcggccgcat cgggggtggt gtcgatgacc ggggtgtggt cgtcggggtt ggtcgcgccg
1789141 ggggcggcca gtttggctag cacggcttca aaggtggccc gcgcttgggg ggtcaggtag
1789201 ccacttagcc gtgacatgcc gtcgtattgc tggttgctca gggtgatgcc gcgtttgcgg
1789261 gcgcgttcgg tgtcggtgag gtcgccgtcg gggtgtagcc agtccatgac ccgctgggcg
1789321 tagcgggcca gctcgtcggg acgatattga gcggctttgc cggccaggtc ggcttcggcg
1789381 gcctggcggg tggacacatc caccgcggcg ggcaggtggg cgaaaaaggg cgcgaatcac
1789441 tttgacgtgc gcctcgccga tcaggccctg gcgttgggcg gtggcggtgg cggtcaactg
1789501 tggggctagc ggttcaccgg tgagtgctcg acgaggtccg agatcggcgg cgtcggcgat
1789561 gcgccgggcg gcgtcgggct tggtgatgcg taaccggttg gccagcgcgc agcacagcgt
1789621 gccgcccagt tcttcctcgc tggcttgggc gtcaagttgg ttgatcaacg cgtgacccac
1789681 cgccggtagc cggcgcacca agcattccag acgttccaga gaccgcagcc gttccggggt
1789741 ggtcaacacc tcaaaagaca cctcgtccaa gcggtccagc tcggcatcca gcgcatcaaa
1789801 gacctcgaca agctcctccc ggctattcgc taacatgttc gaatcataac gtcgggcact
1789861 gacaagaagt cgcgccgaca gctgctagaa ctggtgttag ctaagtgaat tcagtgactc
1789921 gagagccctc gcgagcttgg ccgcccacca ggtcggcggg gatgcctacc aggattcgat
1789981 cccgccaacc ggcaatctga ccaaccgggc ataacccccg ccggtgaacc gcagtttagt
1790041 gagcggcttg aggttgcggg atcgacgatt cggcgtctgg gccgctgtgt gggatgcctg
1790101 gcgggtcgag tgcgagtgct gatagctggg ccgctgccaa cgatccgtga cctccgccca
1790161 cgtcgcgttt gtccccgtgc gcaccgctac cgtagcctga acaccgtttc attcaggccg
1790221 ccgagcaggc ggcggatggg ttccgcgcgt gcggagatga cgaaggatgc aggggagtac
1790281 ctggtgacgc aagcggcaac gcgaccgacg aacgacgccg gccaggatgg cgggaacaac
1790341 tcggacattc tggtggttgc ccgccaacag gtgctgcagc gcggtgaggg cctgaaccag
1790401 gaccaggtgc tggcggtgct gcagctaccc gacgaccggc tcgaggagct gttggcgctg
1790461 gcccacgagg tgcggatgcg ctggtgcgga cccgaggtcg aggtcgaagg catcatcagc
1790521 ctgaaaaccg gtggctgccc ggaggattgc catttctgct cgcaatcggg gctgttcgcc
1790581 tccccggtgc gcagcgcctg gctggacata cccagcctgg tcgaggcggc caaacagacc
1790641 gccaagtccg gcgccaccga gttctgcatc gtggccgcgg tgcgcggacc cgacgagcga
1790701 ttgatggccc aggtcgcggc cggcatcgag gcgattcgca acgaagtcga gatcaacatc
1790761 gcctgctccc tagggatgct gaccgccgag caagtggacc aactggcggc gaggggggtg
1790821 catcgctaca accacaacct cgaaacggcg cgctcgttct tcgccaacgt cgtcaccacc
1790881 cacacctggg aagagcgctg gcagacgcta tcgatggtgc gtgacgcggg catggaggtt
1790941 tgctgcggcg gcatcctcgg catgggggag acgctgcagc agcgcgcgga attcgccgcc
1791001 gagcttgccg agctgggccc cgacgaggtc ccgctgaact tcctcaaccc gcggcccggt
1791061 accccgttcg ccgacctgga ggtaatgccg gtcggtgacg cgctcaaggc ggtggccgcc
1791121 ttccggttgg cgttaccgcg caccatgctg cggttcgccg gtggccgcga gatcaccctg
1791181 ggtgacctcg gcgccaagcg aggcatcctg ggcggcatca acgccgtgat cgtcggcaac
1791241 tacctgacca ccctcggccg gcccgcggaa gccgacctgg aactgctcga cgagctacag
1791301 atgccgctga aggcactcaa cgccagcctg taaatggtgg aaatcgtggc tggaaaacaa
1791361 cgcgctccgg tcgctgccgg cgtgtacaac gtgtacaccg gggaactggc ggatacggcc
1791421 acgccgacag cggctcggat gggtctggag cccccccggt tctgtgcgca gtgcggtcgc
1791481 cggatggtcg tccaggtccg gcccgacggc tggtgggcgc gctgttctcg ccacgggcag
1791541 gtggactcgg ccgacttggc gacacagcgg tgaccgagcc acccggtttt ggcggaccgt
1791601 ccgagccttc cggtgcaccg cggacgtcgc ggacacgggc ggtcctgttt gtgatgctgg
1791661 gtctgtcggc gaccggtgtg ttggtcggtg gcctgtgggc gtggatcgcc ccgccaatcc
1791721 atgccgtcgt ggccatcaca cgcgcgggtg agcgggtgca cgagtatctg ggcagcgaat
1791781 cccagaactt cttcatcgcg ccatttatgc tgctggggct cttgagtgtg ctggctgtcg
1791841 tggcatcggc attgatgtgg cagtggcgag agcaccgcgg accgcagatg gttgctgggc
1791901 tgtcgattgg gctgacgacc gctgcggcga tcgcggcggg agttggcgcg ctggtggttc
1791961 ggttgcgcta cggtgcgttg gactttgaca ccgtgccact ttcccgcggc gaccacgccc
1792021 tgacgtacgt cacccaggcc ccgccggtgt ttttcgcccg ccggccgctg cagatcgccc
1792081 tcactctcat gtggccggct ggcatcgcgt cgctggtata tgccctgctt gcggccggga
1792141 cggcgcggga cgacctgggc ggctatccgg ctgtcgatcc gtcgtcgaac gctcgtactg
1792201 aagccctgga aacccctcag gccccggtgt cctaggagag tcgcagccgc ccgccggcat
1792261 ccggagcgga ccgtgtctcc ggtcgggtgt cagcgcttgg attcaagcgg cagatcgtcg
1792321 aactggttta agtctggcgt gacgaggttg tgtgccaggt ccgagttcgc gccggtatgc
1792381 gcagagcgca ttggccaggt cagagcggac ggcggctcaa cttcctgccg gtgatcacct
1792441 tggccgcgat cacggccagt ctcgccatgc cggcgtaggt catcgggttg aagatggtcg
1792501 gccacgtggt ccggacgcgg tggtcggtca gtggcttgcc ggcgaaccgg tcggtgagcc
1792561 agcgaagcgt cattggggcc gacagcgggt gcagggacac atgttcgctg aacaggtcgc
1792621 ggtggtaggt gacgttggcg ccgccggctg tatagctgtc agcgagcgcg tcgatgtcag
1792681 agacgtcgat gaggtagtca tgcacggcct gcacgatcaa taccggcggg gtgggcaccg
1792741 cgctacccag cttggtgtcg ccgaagacat gggaaatttc cggcgtcgac agaatgtcct
1792801 caaggggttc gtcgaggaag tcacccatgt ccctgccggc catccggatc actgcgtcta
1792861 ccgttgtcat ctccgtcagt tgctccagca gctgacgtcc ttcgtcgttg gcgtgctcct
1792921 tgatcacccg ggccaggccg gggtagctgt gttgcagcgc ggccaccacc aacgcgggca
1792981 gaccggcaag aagagtgcca ttgagccggc ggaacgtgtg accaaggtca ccgacgggtg
1793041 atcccagcac ggcgccgacg atgtctaggt ccggtgcgta ctcgccgcat gcttcggcgg
1793101 cccacgcgct ggccagcccg ccgccggagt agccccacag cccgatcggc gttgccgggg
1793161 acaacccgac acgctcggaa ttcaaggcag cccggattcc gtcgaggact cggtaaccgg
1793221 gttcatacgg cgacccccac agccctttcg gcccttcatg gtcgggtact gataccgccc
1793281 atccttcggc aagtgcggcg ctgatcatca acagctccat ttgggtcagt gaccccaggg
1793341 ccttggcccg tcgtcgcagg gcatatgacg gaaaacagcg cgacgacatg gcatcgatcg
1793401 cacactggta cgacagcaag gggcaggtct gacccggggc aagctccgct gggacgatca
1793461 ccgtggtcac cgtcgcctcg gggttgccgt acatgttcgt ggtccggtac agcagctggg
1793521 tagcggtgac gggctgcgga atcaagccca taaacgccag ttcgacatcg cgcgagcgca
1793581 acaccgttcc gggcacggca tgctggtagc cggcaggtgg gaagtagaac ggatcgtcgg
1793641 atggcagcag cgggcgcact ttgcgctgca attcctcgtg cggtggccgg ccgatccatt
1793701 cggcgccggt cgcgcctgcc aaattgccgg gctctaccat taggctccct tcatggccat
1793761 ccggcatcct cgcgcgtgat cggtccctga cggggtagca gcgcggtttg cctgtcgcag
1793821 ttcagcgccg gcactcaagg tcagcgtcgg cactcgaatg gcgccagcgg ctcttatccg
1793881 gctcttaaag tctcatacaa gttacaggat ccaagggccg actccgaggc cagcgcggcg
1793941 tggcgcctat cacaggttgg gtacgccgag ttcccccatc gctggtgcga ccagattcaa
1794001 agctggccgg gaggccgcag tgcggcgaac tcgtcagtga ctcttagctg cgagtcggta
1794061 aaccggtaca acgccgccgg gcggccaccg ctgcggccgg actgcgcgat ggttccggtt
1794121 tgggtgatga ctctgcgacg ggccagtacc cgctgcaggt tggttgcgtc gacctggtag
1794181 cccagtgcgg cgccgtagat gtcgcgcagc gttgagagcg cgaattcttt tggggccaaa
1794241 gcgaatccga tgtttgtata ggacatcttg gcaatcagcc gggtgcgggc atgggtcacc
1794301 atcggaccgt gatcgaacgc cattggcggc aaggaactca ccgggtgcca gcgggtgtct
1794361 gctggcagct cgggggtggc gggggagggc accaccccca ggtaggtcga cgcgatcatc
1794421 cggatgcctg gcagccggtg tgggtcggaa aacaccgcga gctgttctag atgggccaac
1794481 tctcgcaggt cgactttctc ggccagttgg cgccgaaccg agctggtcat gtcttcgtcg
1794541 ttgcgtagcc gtccgcccgg cagcgaccac gcgccgcgct gcggctcctt cgcacgttgc
1794601 cacagcagca cattgagctg gggttttgcc gcaccgcggc tcatgccaac tccgcgcact
1794661 tgaaagacga cggccagcac ttcgtgggcg gtgctaccat gggccatgtt ttcgattata
1794721 agtcgaaaac ctgttggagc gcggaagggg cggcaatgac tgtgctgaat cgcacggaca
1794781 cgctcgtgga tgaactgact gccgacatca ccaacacacc gctcggctac ggcggggttg
1794841 acggtgacga acggtgggcc gccgagattc gccgtctggc gcatttgcgc ggggccaccg
1794901 tcctggcgca caactaccag ctgcccgcga tccaggacgt tgccgaccac gtcggggatt
1794961 cgctggcgct atcgcgggtg gccgccgagg caccggagga caccatcgtg ttctgcggag
1795021 tgcacttcat ggccgagacc gccaaaattc tcagcccgca caaaaccgtg ctgatcccgg
1795081 atcagcgggc cggctgttcg ctggccgatt cgatcacccc cgacgagctg cgcgcctgga
1795141 aggacgagca tcccggcgcc gtcgtcgttt cctacgtcaa caccacggcg gccgtcaagg
1795201 cgctcaccga catctgctgc acctcgtcaa acgccgtcga cgtggtcgca tccatcgatc
1795261 ccgaccgcga ggtgttgttc tgtccggacc aattcctcgg tgcacacgtg cgccgggtga
1795321 ccggccgcaa gaacctgcat gtgtgggccg gcgaatgcca cgtacacgcc gggatcaacg
1795381 gcgacgagct cgctgaccag gcccgcgcac atcccgatgc cgaactgttc gtgcatccgg
1795441 agtgtggttg cgcaacctcg gcgctatacc tcgccggcga aggagcattc ccagccgagc
1795501 gggtaaagat cttgtccacc ggcggcatgc tcgaagcggc gcacacgacg cgcgcccgcc
1795561 aggtgctggt cgccaccgag gtcggcatgt tgcaccagct tcgccgggcg gcaccggaag
1795621 tcgactttcg cgcggtcaac gaccgcgcct catgcaagta catgaagatg atcacccccg
1795681 cggccctgtt gcgctgcctg gtagagggtg ccgacgaagt ccatgtcgat ccgggaatcg
1795741 ccgccagtgg gcgtcgcagc gtgcagcgga tgatcgaaat cggccatccc ggcggtggcg
1795801 aatgatggcc ggtcccgctt ggcgggatgc ggccgatgtt gtcgtgatcg gcacgggcgt
1795861 tgccgggctg gcggcggcat tggccgccga tcgcgccggg cgcagcgtcg tggtgctcag
1795921 caaggctgcc cagacgcacg tgaccgcgac acactacgcg caaggcggta tcgcggtggt
1795981 gctgccggac aacgacgact cggtcgacgc tcacgtcgcg gacaccttgg ccgcaggcgc
1796041 gggcctatgc gatcccgatg cggtgtactc gatcgtcgcc gacggctacc gagcggttac
1796101 cgatttggtc ggagctgggg cacggttgga tgaatcggtc ccgggccgtt gggcgttgac
1796161 gcgcgaaggc gggcactcgc ggcgacgcat cgtgcacgcg ggtggcgacg cgaccggcgc
1796221 cgaggttcag cgggcgctcc aggatgccgc cgggatgctc gatatccgca ccggccacgt
1796281 ggcgttgcga gtgctgcacg acggtaccgc ggtgaccggg ctattagtgg tcagaccgga
1796341 cggatgcggc attatcagcg ctccgtcggt gatcctggcc accggcgggc tcgggcacct
1796401 gtacagcgcg accaccaatc cggcgggctc caccggcgac ggcatcgccc tgggattgtg
1796461 ggcgggcgtc gcggtcagcg atctcgagtt catccagttc caccccacga tgctttttgc
1796521 cggacgcgcc gggggtcggc ggccgctgat caccgaggcc atccgcggcg agggtgcgat
1796581 cttggtggac aggcaaggca attcgataac ggcaggcgtg catccgatgg gtgatttggc
1796641 gccgcgcgac gtcgtcgccg ccgccatcga cgcgcggctg aaggccaccg gcgatccgtg
1796701 cgtctacctc gacgcccgcg gcatcgaggg cttcgcgtcc cggttcccga cagtcacggc
1796761 atcctgccgg gctgccggca ttgaccccgt ccggcaaccg atcccggttg ttcccggtgc
1796821 gcactacagc tgcggcggca tagtgaccga tgtgtacggc cagaccgagc tgctcgggtt
1796881 gtacgccgct ggcgaggtgg cccgcaccgg gttgcacggc gccaaccgcc tggcctccaa
1796941 cagcttgcta gagggtttgg tggtgggcgg ccgcgccgga aaggccgccg ccgcccacgc
1797001 cgcggcggcc gggcgttcgc gtgcgacctc gtcagcgacc tggcccgaac cgatcagcta
1797061 caccgcactg gaccgcggcg acctgcaacg ggcgatgagc cgggacgcgt cgatgtaccg
1797121 cgccgccgcc gggctgcacc ggctgtgcga cagcctatcc ggagcacagg ttcgcgacgt
1797181 ggcttgtcgc cgcgatttcg aggacgtggc gctcacgctg gtcgcgcaga gcgtgaccgc
1797241 cgccgccttg gcccgcaccg aaagccgtgg ctgccatcat cgcgcggagt acccgtgcac
1797301 cgtgccggag caggcacgca gcatcgtggt ccggggagcc gacgacgcaa atgcggtgtg
1797361 tgtccaggcg ctagtggcgg tgtgctgatg gggttatccg actgggagct ggctgcggct
1797421 cgagcagcaa tcgcgcgtgg gctcgacgag gacctccggt acggcccgga tgtcaccaca
1797481 ttggcgacgg tgcctgccag tgcgacgacc accgcatcgc tggtgacccg ggaggccggt
1797541 gtggttgccg gattggatgt cgcgctgctg acgctgaacg aagtcctggg caccaacggt
1797601 tatcgggtgc tcgaccgcgt cgaggacggc gcccgggtgc cgccgggaga ggcacttatg
1797661 acgctggaag cccaaacgcg cggattgttg accgccgagc gcaccatgtt gaacctggtc
1797721 ggtcacctgt cgggaatcgc caccgcgacg gccgcgtggg tcgatgctgt gcgcgggacc
1797781 aaagcgaaaa tccgcgatac ccgtaagacg ctgcccggcc tgcgcgcgct gcaaaaatac
1797841 gcggtgcgta ccggtggcgg cgtcaaccat cggctggggt tgggtgatgc cgcgctaatc
1797901 aaggacaacc acgttgccgc cgccggatcc gtggtagacg cgctacgtgc ggtgcgaaat
1797961 gctgcacccg atctgccgtg cgaggtggaa gtggactcgc ttgagcagct cgatgccgtg
1798021 ctgccggaaa aacccgagct gatcctgctg gacaattttg cggtgtggca gacgcagacc
1798081 gcggtgcagc gtcgggactc gcgcgcgccc accgtcatgc tggagtcatc cggtgggctc
1798141 agcctgcaga cggcggcgac ctacgccgaa accggggtgg actacctggc ggtcggggcg
1798201 ctcacacact cagtgcgcgt gctcgacatc ggcttggata tgtagccggg cggccccggc
1798261 gcccattagg cggcgccgga tagggtaggc gccgtggcgc gaacgttcga agatctcgtg
1798321 gccgaagccg catcagcatc cgtcggcggc tggggttttt cctggttgga cggccgcgcg
1798381 accgaagaac gcccgtcatg gggctatcaa cgacaactca gtcagcggct ggcgaacgcg
1798441 acggctgcct tagatcttga gacaggcggc ggagaggtgc tagccggcgc gggcaacttc
1798501 ccgcccacca tggtcgctac cgaagcgtgg ccacccaacg cggctatggc cactaggcgg
1798561 ctgcatccgc tgggcgcggt cgtcgtcatc accggcgata aaccgccact gccctttgcc
1798621 gatgcggcgt ttgacctggt gaccagccgc caccccagca cccgatggtg gaccgagatt
1798681 gcccgggttc tccgggctgg cggcagttac ttcgcccaac acgtcggacc ggccacgctg
1798741 tgggacctgc gcgagcattt cctcgggccg cgagaacaca acggggccga tcagtacgcg
1798801 caggttgtgc gcacctgcat caccgacgcc ggcctcgaga tcgtcgacct gcagatggag
1798861 cggttgcggg tggaattctt cgacgtcggt gccgtcatct actttctgcg caaggtgatc
1798921 tggtttctgc cggacttcac cgtcgagggc taccacgatc ggctgcgtgc actgcatgag
1798981 cgcatccagg ccgaagggcc cttcgtcacc tactccaccc gcgcgctcat cgaggcccgc
1799041 aaaccgtcct gacgtcggcc ggggccttag gctcaggcga tatcgccgac gaagaccccg
1799101 atccggcgca gctgcaagcg cgccatccgc ggcagcccct gaccgtcgga gccggcgggc
1799161 acaatccggg ggttgatgac gtgaacaacg ccgcgggcga agtgcacgtc ggcttcgccc
1799221 gcggccaaca cgttcttgac ccaatccgtc ttaccgtgcg cgagcgcgat cgccagcaca
1799281 ccgtccttgc ggtaggcggt cacaatcgtt tggtatggct ttccagactt gcgaccgcgg
1799341 tgctcgatcg tggccgttcc gggtaggtag cgcgctatcg gtttgagcgc ccggttgatg
1799401 tacttgacct gcagacgctc gagccagagc gggaacacca tcggaacgcc cggggcgtta
1799461 ttcgggtgat cctttgcgga catggcggct cctctttgcc ggtcctttct actgcactgt
1799521 accggtcaga tatcgacttg agctgctctg ggagaatggt ctacgtgacc gcgccgccgc
1799581 ccgtgcttac ccgtatcgac ttgcggggag ccgagttgac agctgccgag ctgcgggccg
1799641 ctctgccacg cggcggcgcc gatgtggaag ccgtgctgcc gacggtacgg cccattgtgg
1799701 cggccgtcgc cgagcgcggg gccgaggccg cgctggactt cggcgcatcg ttcgacggtg
1799761 tgcggcccca tgccatccgg gtgccagacg cagcgctgga cgcggcgctg gccggactgg
1799821 actgcgacgt ctgcgaagcg ttgcaggtga tggtcgagcg gacccgcgcc gtgcactccg
1799881 ggcagcgtcg caccgacgtc acaaccacac tgggcccggg cgcgacggtc accgagcggt
1799941 gggttccggt cgagcgggta ggcctgtacg tgccgggggg caatgcggtg tacccatcca
1800001 gcgtggtgat gaacgtggtg cccgcccaag ccgcgggcgt cgactcgttg gtggtagcca
1800061 gcccgccgca ggcgcagtgg gatggaatgc cgcatccgac cattctggcc gcggcccggc
1800121 tgctgggcgt cgatgaggtc tgggcggtcg gcggcgctca ggcggtggcg ttgctggctt
1800181 acggcggcac cgacaccgac ggcgcagcac tgacaccggt cgacatgatc accgggcctg
1800241 gcaacatcta tgtcacggcc gccaagcgac tgtgccgttc gcgggtgggc atcgacgccg
1800301 aagcggggcc aaccgagatc gctatcctcg ccgatcacac cgccgacccg gtgcatgtgg
1800361 ccgccgacct gattagccag gccgaacacg acgagttggc tgccagcgtg ctggtcactc
1800421 cgagtgagga cctggccgat gccaccgacg ccgaactggc tggccagctg cagactacgg
1800481 tgcaccgcga acgggtgacg gccgcgctga ccggacgcca atcggcgatc gtcctggtcg
1800541 acgacgtgga cgccgccgtc ttggtggtga acgcttacgc cgctgagcat ttggagattc
1800601 agaccgccga tgccccgcag gttgccagcc ggatccgctc ggcgggagcc attttcgtcg
1800661 gcccgtggtc cccggtgagc ctcggcgact actgcgcggg atccaaccat gtactgccga
1800721 ccgcgggctg cgcccggcat tccagcggcc tgtcggtgca gacgttcctg cgcggcatcc
1800781 acgtcgtgga atacacggag gcggccctca aagacgtttc cggacacgtg atcacgctcg
1800841 ccacggccga ggacttgccg gcgcacggtg aggcggtacg gcggaggttc gagcgatgac
1800901 caggtccgga cacccggtta cattggacga cttgccgctg cgcgccgact tgcgtggtaa
1800961 agcaccatac ggtgcaccgc aattagctgt tccggtacgg ctgaacacca acgagaaccc
1801021 gcacccgcct acccgggcgc tggttgacga cgtggtgcga tcggtgcggg aagcggccat
1801081 cgacttgcac cgctaccccg accgcgacgc cgtggctctg cgtgctgact tggccggcta
1801141 tctcaccgcg cagaccggaa tccagcttgg tgtcgaaaac atatgggctg ccaacggttc
1801201 caatgagatt ctgcagcaac tgttacaggc gtttggcggt ccggggcgta gcgcgatcgg
1801261 tttcgtaccg tcctattcga tgcacccgat catctccgac ggcacccaca cggaatggat
1801321 cgaggcgtcc cgcgccaatg acttcggtct cgacgtggac gtcgccgtcg cggctgtggt
1801381 cgatcgcaaa cccgatgtgg tgttcattgc tagccctaac aacccgtccg gacaaagtgt
1801441 ttcgttacct gacctgtgta agctgctgga cgttgcgccc ggaattgcga tcgtcgacga
1801501 ggcctacggc gagttctcct cgcagcccag cgcggtgtcg ctggtcgagg agtatccgag
1801561 caagctcgtc gtcacgcgca ccatgagcaa ggcattcgct ttcgccggcg gcaggctcgg
1801621 atacctgatc gctacgcccg cggtgatcga cgcaatgctg ctggtgcggt tgccgtatca
1801681 cctgtcgtcg gtcactcaag ccgcggcccg ggccgcgctg cggcactccg acgacacctt
1801741 gagcagtgtc gccgcactga tcgccgaacg cgaacgcgta acaacctcat tgaacgacat
1801801 gggttttcga gtcatcccaa gcgatgccaa cttcgtgttg ttcggcgagt ttgccgatgc
1801861 gccggccgcc tggcggcgct atctggaggc cggcattttg atccgcgacg ttgggattcc
1801921 cggctatctg cgggccacca ccgggctggc tgaggagaac gatgcgttcc tgcgggcaag
1801981 cgcccggatc gccaccgacc tggtccccgt cacccgcagt cctgtaggag cgccatgaca
1802041 accacccaga cagccaaagc tagccggcgg gcgcgtatcg aacggcgtac ccgcgaatcc
1802101 gatatcgtca tcgagctcga ccttgacggt accgggcagg tggccgtcga caccggtgtt
1802161 ccgttctacg accacatgtt gaccgcgctg ggcagtcacg ccagcttcga cctcaccgtg
1802221 cgcgccacag gtgatgtcga aatcgaagcc catcacacca tcgaggacac ggcaatcgcg
1802281 ctgggcaccg cgctcgggca ggccctaggt gacaagaggg gcatccgccg gtttggcgat
1802341 gccttcatcc cgatggacga aacactggcc cacgccgccg tcgacttatc cggccgcccc
1802401 tattgcgtgc ataccggaga gccggatcac ctgcagcaca ccactattgc cggcagttca
1802461 gtgccctacc acaccgtcat caaccggcac gtgttcgaat cgttggcggc caacgcccgc
1802521 atcgcgctgc acgtccgcgt gttgtacggg cgcgacccgc accatatcac cgaagctcaa
1802581 tacaaggccg tcgcgcgcgc gttgcgtcaa gcggtcgagc cagatcctcg ggtgtcaggc
1802641 gtgccgtcca ccaaaggtgc tctgtgacag caaaatcggt tgtagtcctt gactacggct
1802701 caggaaacct gcggtcggcc caacgtgcgc tgcaacgagt aggcgccgag gtcgaagtaa
1802761 ccgccgatac cgacgccgca atgaccgctg acggactggt ggtgccgggc gtcggtgctt
1802821 tcgcggcgtg catggcgggc ctgcgcaaga tcagcggaga gcgaatcatc gccgagcggg
1802881 tggccgccgg ccgcccggtg ctgggggtct gtgtcggtat gcagattctg tttgcttgcg
1802941 gggtcgaatt cggtgtgcag acgccaggct gcgggcactg gccgggggcg gtcattcgac
1803001 ttgaggcccc ggtgattccg cacatgggct ggaatgtcgt ggattccgct gcgggcagcg
1803061 cgctgttcaa agggttggac gtcgacgccc ggttttattt cgtgcattcc tatgccgcgc
1803121 agcgatggga aggctcaccc gacgcgctgc tgacctgggc cacatatcgg gcgccgttcc
1803181 tcgctgcggt ggaggacggc gcattggccg ccacccagtt tcatccggag aagagtggcg
1803241 atgccggtgc agccgtactg agcagctggg ttgatggact ttaaaggata ctggtgatgc
1803301 cgctgatact tttgcccgcc gtcgacgtgg tcgagggtcg tgccgtgcgc ctcgttcaag
1803361 ggaaggccgg cagccaaacc gagtacggct cagcggtgga tgccgcgttg ggctggcaac
1803421 gcgatggcgc cgagtggatc catttggtgg acctggatgc tgcgttcggc cgcggttcca
1803481 accacgaact gcttgccgag gttgtcggca agctcgacgt acaggttgag ctatccggcg
1803541 gtattcgaga cgacgagtcg ctggccgcgg cgctggccac cggatgcgct cgggtcaatg
1803601 tgggcactgc tgccctggaa aacccgcagt ggtgtgcccg ggtgattggc gagcacggcg
1803661 accaggtcgc cgtcggcttg gacgtccaga tcatcgacgg cgagcatcgg ttgcgcggac
1803721 gcggctggga aaccgacggc ggcgacctgt gggacgtgct agaacgccta gacagtgaag
1803781 gatgttcgcg gttcgtcgtg accgatatca ccaaggacgg caccctgggc ggccccaatc
1803841 tggacctgct ggccggtgtt gccgaccgca ccgacgcccc ggtgatcgcg tccggaggtg
1803901 tgtccagcct cgatgacctg cgcgccattg cgactctcac gcaccgcggc gtcgaggggg
1803961 ccatcgtcgg caaggccctc tacgcccgtc ggttcacctt gccgcaagcg ttggccgcgg
1804021 ttcgggacta gatcggcgat gcacttggat tcgttggttg ccccgctggt tgaacaggcg
1804081 tcggcgatcc tggatgccgc aacggcgctc tttctcgtcg gtcatcgcgc cgattcagcg
1804141 gtccgcaaga agggtaacga cttcgccacc gaagtcgatc tagcgatcga gcggcaggtt
1804201 gtcgcagcgc tggtggcggc caccggcatc gaggtgcacg gcgaggagtt cggcggcccg
1804261 gcagtcgact cgcggtgggt gtgggtactg gaccccatcg acggcacaat caactacgcc
1804321 gccggatcgc cgttggctgc gatcctgttg ggcctgctgc acgacggagt tccggtggcc
1804381 ggcttgacct ggatgccatt caccgaccca cgctataccg ccgtggcggg tggtccgctg
1804441 atcaagaacg gtgtaccgca gccgccgctg gctgacgccg aactggccaa cgtgctcgtc
1804501 ggcgtcggca cattcagcgc cgactcacgg ggccagttcc cggggcgata tcgactggcg
1804561 gtgctggaaa agctcagccg agtgtcatcg cggctgcgca tgcacggatc caccggcatc
1804621 gatctcgtct tcgtcgctga cgggatactc ggtggtgcaa taagtttcgg aggtcacgtt
1804681 tgggaccatg ccgctggggt ggcgttggta cgagccgccg gtggcgtggt caccgacctg
1804741 gctgggcaac cgtggacccc tgcatcgcgt tctgccttgg ccgggccacc gcgcgtgcat
1804801 gcccagatcc tcgagattct tggcagcata ggggaaccag aggactactg agatgtatgc
1804861 cgaccgtgac cttccggggg ctgggggcct cgcggtacgc gtgatcccgt gtctggatgt
1804921 cgacgatggg cgggtggtca agggagtcaa cttcgagaac ctccgcgacg ccggtgatcc
1804981 cgtggaactc gccgccgtct atgacgcgga gggcgcggac gagttgacct ttctcgacgt
1805041 gaccgcgtcg tcgtccggaa gagccaccat gctggaggtg gtgcgccgca ccgccgagca
1805101 ggtgttcatc ccgctgacgg tgggcggtgg ggtacgcacc gtcgccgacg tcgattcgct
1805161 gctacgggct ggggctgaca aagtcgccgt caacacggcc gccatcgctt gcccggactt
1805221 gctggcggac atggcgaggc agttcggctc gcagtgcatc gtgttgtccg tcgacgcgcg
1805281 cacagttccg gtgggatcag ccccgacacc gtcgggttgg gaggtcacca ctcacggcgg
1805341 tcgtcgtggc accggtatgg acgccgtgca gtgggcggcc cgtggcgccg acctcggtgt
1805401 gggggagatc ctgctcaact cgatggacgc cgacggcacc aaagccggat tcgacctggc
1805461 tttgctgcgt gcggtccgtg ccgcggtcac ggtgccggta atcgccagcg ggggcgccgg
1805521 tgctgtggag cacttcgcgc cagcggttgc cgcgggggcc gatgcagtgt tggcggccag
1805581 cgtctttcac ttccgggagc tgacgatcgg tcaggtgaag gcggccctgg ccgcggaagg
1805641 aatcaccgtg cgatgacact cgacccaaag atcgcggcgc ggttgaagcg taatgccgac
1805701 ggactggtta ccgccgtcgt ccaggagcgg ggcagcggtg acgtgctgat ggttgcctgg
1805761 atgaacgacg aggccttggc ccgtaccctg caaacccgtg aggccactta ctattcgcga
1805821 tcccgtgccg aacaatgggt caagggcgcg acgtccggcc acacccagca cgttcactcg
1805881 gtgcgcctgg attgtgacgg cgacgccgta ttgttgacgg ttgaccaggt cggcggtgcc
1805941 tgccataccg gcgatcacag ttgcttcgat gccgcggtgt tgttagaacc cgacgactaa
1806001 cccgccgcgg aaagactggg gctagcggct cgcggcgcaa cagattgcag tggtcgcccg
1806061 cgaggcaaga gtgcccatcg acacgccgcc gagcgagcgc ggacatacca ccttgggatc
1806121 catgcagatg tcaagggggg ttgcccgtcc gggcgatggc gtcgatgaga atggcggtcg
1806181 atgctgaaac gagtgccctg gaccgttgtg ctgccttcgc tggcctttgt cgcgctggta
1806241 ttgacctggg gaaagcagat cggcccggtg gtgggcttgc tagcggcggt gctgttagcc
1806301 ggtgctgtcc tggccgcggt caaccatgcc gaggtggtgg cggcccgggt gggtgagcca
1806361 ttcggttcgc tggtgctcgc ggtcgcggtg acgaccatcg aggtggcgct gatcgttgcg
1806421 ctcatggtgt ccggcgggga cgatgcggcg acgctcgccc gcgacaccgt gttcgccgcg
1806481 gtgatgatca ccaccaacgg gatcgccggg ttgtccctgc tgctgggttc gctgcgctat
1806541 ggcgtgacgt tgttcaaccc ccacggcagc ggcgccgcgc tggccacggt caccacactg
1806601 gcgacgctga gcctggtgct gcccacgttc accaccagtc agtcgggccc cgagctatcg
1806661 cccggccagc tcatcttcgc cggcgccgcg tcgctgggac tctacgtgtt gttcctgttc
1806721 acccagactg tccggcatcg agacttcttc ctaccggtgg cgcaaaaggg cgcggtcgag
1806781 gatgacagcc acgccgatcc accgagcacc cgcgcggcgc tgctgagcct tggattgctg
1806841 ctcgtcgctt tggttgcggt ggtgggtctg gccaaggtgg aatcgccggt catcgaggag
1806901 gtcgtctcgg cggccgggtt tccgcaatcc ttcgtcggcg tggtcatcgc cacactggtg
1806961 ctgttgccgg agacacttgc ggcggcccgc gcggcccggc aaggccgcct gcagaccagc
1807021 ctcaatctgg cgtacggttc cgcgatggcg agtattggac tcaccatccc gaccatcgcc
1807081 cttgcttccc tgtggctcag tggcccgctg caacttggcc tcggtgccat tcagttggtg
1807141 ctgctggtgc tcacggttgt ggtcagcgtg ctgaccgtgg ttcccggtcg ggccacccgt
1807201 ctgcagggcg aggtgcatct ggtgttgctg gctgcttacc tgtttcttgc cgtcgtcccg
1807261 tgatgaatcc gtgcgcaagc gatggttttc gccgccgcta tccagatctg attgcccgca
1807321 gcgtcgctaa cgctttgtcg gcgtgggcgt ccatgctgaa ttcgctggag atcacgtcga
1807381 gcaccttacg gtcggtgtcg atgacaaagg tcgtgcgttt gaccggcatc aacttgccca
1807441 acagaccgcg cttgaccccg aattgggcgg cgaccgtgcc ttgggcgtcc gaaagcagcg
1807501 ggtagtcgaa acgccgcacc tcggcgaatt tggcctgctt tcgaacggga tcggtgctga
1807561 tgccgacccg gctggccctg acctcggcga attctttggc caagtcgcgg aagtggcagg
1807621 cttctttggt gcagccaggc gtcatcgccg ccggatagaa gaacaggacc acgggtccgt
1807681 cggatagcag gacgctaagc ctgcgaggag tcccggtctg atcgggcagt tcgaagtcgg
1807741 ctaccgtgtc accggttttc atagtcgtca ggctacaacc gattgcccga ctccttgcgc
1807801 gccgcttcgc ggctgggggt gcccccatgc gcgccgtttg cgcggcgtgc atcgtcgtcg
1807861 ggctacgccc gggccgatcg gcgtatctgg gaagatggtt cggtgcacgc cgacctcgca
1807921 gccaccacct cgcgtgagga tttccgcctc ctggcggccg agcaccgggt ggttccggtg
1807981 actcgcaagg tcttggccga cagcgagacg ccgctgtcgg cctaccgcaa gctcgccgcc
1808041 aatcgcccgg gtacgttcct gctggagtcg gccgagaacg gccggtcgtg gtcgcgatgg
1808101 tcgtttatcg gtgcgggggc gccaacggcg ttgaccgtgc gtgaggggca agcggtatgg
1808161 ctgggtgccg tgcccaagga cgctcccact ggcggagacc cgctgcgggc gctgcaggtg
1808221 accttggagc tgctggctac ggcggatcgt cagtccgagc cgggtcttcc gccgctgtcg
1808281 ggtggcatgg tcggtttctt cgcctatgac atggtgcgac ggctggaacg attgccggaa
1808341 cgggccgtcg atgacctctg cctgccggac atgctgctgt tgctggccac cgatgtggcg
1808401 gcggtcgatc accacgaggg caccatcacg ttgatcgcca acgccgtgaa ctggaacggc
1808461 accgacgagc gggtcgactg ggcctacgac gacgcggtcg ctcggctgga cgtgatgacc
1808521 gcagcgctcg gccaaccact accgtcaacc gtggccacct tcagccgacc cgagccgcgc
1808581 caccgtgcgc aacgcaccgt cgaagaatat ggtgcgatcg tcgaatactt ggtggatcag
1808641 attgcagccg gtgaagcgtt ccaggtggtg ccctcgcagc gcttcgagat ggacaccgat
1808701 gtcgatccca tcgacgtgta ccgaattctg cgggtaacca acccaagtcc ctacatgtat
1808761 ctactgcagg tgccgaatag tgatggtgca gtggactttt cgattgttgg atccagtccg
1808821 gaggcgctgg taacggtcca cgaaggctgg gcgacgacgc atccgatcgc cggaacccgg
1808881 tggcgcggaa ggacagacga cgaggacgtg cttctggaaa aagagctgct ggcggacgac
1808941 aaagaacgtg ccgagcatct gatgctggtc gacctcggcc gaaacgacct gggtcgggtc
1809001 tgcacgccgg gcactgttcg ggtcgaggat tacagccaca tcgagcggta cagccacgtg
1809061 atgcacctgg tgtccacggt gaccgggaag ctcggcgaag ggcgcaccgc gctggacgcg
1809121 gtgaccgcct gctttccggc cggcacgctg tcgggcgcgc cgaaggtgcg ggcgatggag
1809181 ctgatcgaag aggtggagaa gacacgccgc ggcctttacg gcggtgtcgt cggttacctt
1809241 gacttcgccg gcaacgctga cttcgccatc gccatccgca ccgcgctgat gcgtaacggc
1809301 acggcttatg tccaggcagg cggtggtgtg gtggccgact ccaacggatc ctacgaatac
1809361 aacgaggcga ggaacaaggc tcgggctgtg ctcaacgcga tcgctgccgc cgagacgctg
1809421 gccgctccgg gcgcgaaccg cagtggctgc taatgccggc agtgttcggc ccaaccgccg
1809481 ggccaggccg atgatcggca tcgcccagtt gctgttggtg gttgccgccg gggcgctgtg
1809541 gatggccgca cggctgccct gggtggtcat cgggtcattc gacgagctgg ggccgccgaa
1809601 ggaggtgacg ctgaccggtg cgtcgtggtc gaccgctttg ctgccgttag cgctgctgat
1809661 gctggccgcg gcggtggcgg cgctcgcggt gcgcggctgg ccgctgcggg cgctggcagt
1809721 gttgctggcc gcggccagct tcgcggtcgg ctacctcggc atcagtctgt gggtggtccc
1809781 ggatgtcgcg gcccgcggag ccgatcttgc ccatgtccca gtggtgacgc tggtcggaag
1809841 cgcccggcac tattggggcg cggtggcggc ggtgttggcg gcagtgtgtg ctttgctcgc
1809901 tgccgtcttc ttgatgagtt cggcggcgat tcgcgggtcg gctggcgagg acatggcgag
1809961 atatgcggcg ccccgcgccc gccggtcgat tgcccggcgc cagcactcga atgcggccgg
1810021 ccgggcggct ccgcaagacg acgggccgga tatggggccg cggatgtcgg agcgaatgat
1810081 ttgggaagct cttgacgagg gccgtgaccc gaccgatcgg gagcaggagt ctgacaccga
1810141 ggggcggtga cggaccgcgc gctgacggtc gctacccttc atggacgtcg tcgaaattga
1810201 cgagcgcgtg tgggtgacag tgggaaggga acggcaggca tgagtccggc aaccgtgctc
1810261 gactccatcc tcgagggagt ccgggccgac gttgccgcgc gtgaagcctc ggtgagcctg
1810321 tcggagatca aggctgccgc cgctgcggcg ccgccgccgc tcgacgtgat ggccgcccta
1810381 cgcgagcccg gcatcggcgt catcgctgag gtcaagcgcg ctagtccttc ggcaggcgca
1810441 ttggcgacca tcgccgaccc ggcaaagctg gcccaggcct accaggatgg cggtgcccgg
1810501 atcgtcagcg tggtgactga gcagcggcgt tttcagggat cgctcgacga cctcgacgcg
1810561 gtgcgggcct cggtttcgat tccggtgctg cgcaaggact ttgtggtgca gccgtaccag
1810621 attcatgagg cgcgtgcgca cggcgccgac atgttgttgc tcatcgtcgc cgcattggag
1810681 cagtcggtgt tggtgtcgat gttggaccgc accgaatcgt tgggtatgac agcactcgtc
1810741 gaggtccata ccgagcagga agccgaccga gcgctgaagg ccggggccaa ggtgattggc
1810801 gttaacgccc gcgacctcat gacgctggac gtggaccggg attgcttcgc gcgaatagct
1810861 cctggtttgc cgagcagtgt gatcaggatt gctgaatccg gcgtgcgtgg caccgctgac
1810921 ctgctggcgt acgccggcgc gggcgctgac gcggtgttgg taggcgaagg tctggtcacc
1810981 agcggcgacc cacgtgccgc ggttgccgat ctggttaccg cgggcaccca tccgtcctgt
1811041 ccgaaaccgg ctcgctagcc gtcgatgagc cgcttgcatc ttgagcctcg gtgatgacag
1811101 atctatccac cccggatctt ccgcgcatga gtgctgccat cgccgaaccg accagtcacg
1811161 atcctgattc cggcggccat ttcggcggcc ccagtggttg gggtggccgc tacgttcccg
1811221 aggcgctgat ggcggtgatc gaagaggtca ccgccgccta ccaaaaggag cgcgtcagcc
1811281 aggactttct ggacgaccta gacaggctgc aggcgaacta tgcgggccgg ccttcgccgc
1811341 tttacgaggc gacccggttg agccagcacg ctgggtcggc gcgaatcttt ctgaagcgag
1811401 aagacctgaa ccatactggt tctcacaaga tcaacaacgt gctcgggcag gcactgctgg
1811461 cgcgcaggat gggcaagacc cgggtgatcg ccgagaccgg tgccggccag cacggggtcg
1811521 ccacggccac cgcatgcgca ttgctcggcc tggactgtgt catctacatg gggggcatcg
1811581 acaccgcccg tcaggcgcta aacgtggccc ggatgcgatt gctgggtgcc gaagtcgtcg
1811641 cggttcagac gggctcgaaa acgctcaaag acgccatcaa tgaggcgttc cgggattggg
1811701 ttgccaacgc cgacaacacc tactactgct ttggtactgc ggccggaccg catccgtttc
1811761 caaccatggt gcgcgatttc cagcgaatca tcggcatgga ggcacgtgtg cagatccagg
1811821 gtcaggccgg tcggctgcct gacgccgtcg tcgcgtgcgt tggtggcggg tccaatgcca
1811881 ttggtatttt tcatgcgttt ctcgatgacc caggcgtacg gctggtcgga ttcgaggcag
1811941 ccggcgacgg cgttgagacc ggccggcatg ccgcgacatt caccgctggt tcgcccgggg
1812001 catttcacgg atcgttctcg tacttgctgc aagacgagga cggtcagacc attgaatccc
1812061 attcaatttc cgcgggtctg gattatccgg gggtgggccc ggaacatgcg tggctcaagg
1812121 aggccgggcg tgtcgattat cggccgatca ccgactccga ggcgatggac gcgtttggcc
1812181 tgctgtgtcg catggaaggc atcatcccgg ctattgaatc cgcgcacgcg gtggccggcg
1812241 ccctcaagct aggtgttgag ttgggaaggg gcgcggtgat tgtggtgaac ctgtcgggac
1812301 gtggcgacaa agatgtcgag acggccgcga aatggtttgg cttgctgggc aacgactgat
1812361 ggtggcggtg gaacagagcg aagcaagtag gctcgggccg gttttcgatt cctgccgtgc
1812421 aaacaaccgc gcggcattga ttggttactt gccgaccggg tacccggacg tgccagcgtc
1812481 ggtggccgcg atgacagcgc tagttgaatc cggttgcgac attatcgaag tcggggttcc
1812541 gtattcggac ccgggcatgg acggccccac catcgccagg gcaaccgagg cggcgctccg
1812601 tggcggggtg cgagtccggg atacgttagc cgcggtcgag gccatcagta tcgccggcgg
1812661 gcgtgcggta gtgatgacct actggaatcc ggtgctgcgc tatggggttg atgcattcgc
1812721 gcgggatctg gcggcggccg gaggactcgg cctgatcact cctgacctca ttcccgacga
1812781 ggcgcaacag tggctggcgg catccgaaga gcatcggttg gatcgcattt tcttggtcgc
1812841 gccgtcctcg acaccggagc ggttggcggc caccgtcgag gcttcacgcg ggttcgtcta
1812901 cgcggcgtcg acgatggggg tgaccggggc gcgggatgcg gtgtcgcagg cggcacccga
1812961 actggtgggc cgggtgaagg cggtgtctga cataccggtg ggcgtcggtc tgggtgtgcg
1813021 gtcgcgcgct caagccgcgc agatcgccca atacgccgac ggtgtcatcg ttggttccgc
1813081 attggtgacg gcgctaaccg aggggttgcc tagattgcgg gcactgaccg gagagctcgc
1813141 tgccggggta cgactaggga tgtccgcatg atgcggatgt tgcccagcta tatccccagc
1813201 ccaccgcgcg gggtttggta cctgggcccg ctacccgtcc gcgcctacgc agtttgcgtt
1813261 atcaccggca tcattgtcgc actgctgatc ggggatcgcc ggttgacagc ccgcggcggc
1813321 gagcgcggca tgacctacga catcgccttg tgggccgtgc ctttcggcct gattggcggc
1813381 aggctctatc acctggctac cgactggcgg acatatttcg gtgacggtgg tgccgggctg
1813441 gccgcggcac tgcgaatctg ggatgggggc ctgggcatct ggggtgcggt aacccttggt
1813501 gtcatgggcg cgtggattgg ctgccggcgt tgtggaatcc cgctgcccgt cttgcttgat
1813561 gcggtggcgc ctggtgtcgt gttggcgcag gctatcggtc ggctcggaaa ctacttcaat
1813621 caagagctct acggccggga aaccactatg ccgtggggtt tggagatctt ctaccgccgg
1813681 gacccctccg gattcgacgt cccgaattcg ctggacggcg tctcgacggg tcaggtggcg
1813741 ttcgtcgtgc agccaacgtt cctctacgaa ttgatctgga atgttttggt attcgtcgca
1813801 ttgatctaca ttgaccgccg gttcatcatc ggccacgggc gactgtttgg gttctatgtc
1813861 gctttctact gcgccgggcg attctgtgtt gagctgctgc gtgacgatcc cgccacgctt
1813921 attgccggca tccggatcaa ttcgttcacg tccaccttcg tgtttatcgg ggccgtggtg
1813981 tacatcatct tggcgccgaa ggggcgcgag gctcctgggg ccctgcgtgg cagcgagtat
1814041 gttgttgatg aggcgctgga acgtgaaccg gctgaactcg ccgccgctgc tgtggcctcc
1814101 gctgcgagcg ctgtggggcc ggttggcccg ggggaaccga accaacccga cgatgtggcg
1814161 gaagcggtga aagccgaagt cgccgaggtc accgatgaag tggccgcgga atccgttgtc
1814221 caagtagcag accgggatgg tgagtcaacc cccgctgtcg aggagacctc cgaagccgat
1814281 atcgagcggg aacaaccggg cgacctcgcg ggccaggcgc cagccgcgca ccaggtcgac
1814341 gccgaagctg catcggccgc gcccgaggag ccggcagcgt tggcttcgga ggcacacgac
1814401 gaaaccgagc ccgaggtgcc cgagaaggcg gcgcccatcc ccgatccggc caagccggat
1814461 gaattggcgg tcgccggacc tggggacgac cctgctgagc cggacggcat tcgacggcaa
1814521 gacgatttca gctcgagacg ccgccgttgg tggcggcttc gacggcgtcg acaatgacga
1814581 cccacgacgg cactgcctgg tcgccggtgc tggactcaat agaccgccga tcgggcggcc
1814641 gttgccgcag ccggaacgat gcgccgacga agttcccggt cacaaaatgg ccaccggctg
1814701 gaacggtaat cagccgaacc ccgacgcgct tacgagccag accactaagc ccagtaggct
1814761 agcaagcccg gcaggttcca tattttttcg caacccggac gcgcacgcga cgccggggcg
1814821 ctgcctccga tgcccgaccg ccacatgaat atctgtccgt accgctcttt cgtcacgtcc
1814881 gcaacactgg ccttcgccgt cggcgatggt cgctgtgccc agctaagcgc gacaactcgg
1814941 tttctgcagg tcaacgcccg cctccaatcc cgcacagccg cgaccaactc gggaacaaaa
1815001 ccgccggtca ggcagctgtc gctgagagcc gggcacatcg ggtgtcgccc ggtgcagtga
1815061 cacatgtgag agttgtggcc gtgcgatgtg cccgaccctc ggtgcgcacc aatttgagcc
1815121 aactcaggaa atgaatctct gagcggaggt gcaccggttg cccgcctcac aacgacatgc
1815181 tgaggcgcac acggtcgctc gcagccgggc acaacgaaca ctcctgctct gccgcgccga
1815241 tgttgggaac gcatgggcct acggccggca cgggtcgtgc gcccggctcg atctggcatg
1815301 ctgaaaggcg tgaccgatcc cctgcagcac ggtgccttcg agccgggctg gcaatccgca
1815361 ccacccggat atccaccgcc ttatccgcaa tatccggggc ctggctctta ctttgacccg
1815421 ttcgcgccat atggtcgcca tccggtcacc ggccaaccat tttccgacaa atcgaagact
1815481 gttgccggcc tgttgcagtt gcttggactg ttcggcatcg ccgggatcgg gcgaatctac
1815541 ctgggccata ccggcctggg catcgcgcag ctgctggtgg gctgggtgac gtgcggtttg
1815601 ggcgccgtca tctggggcgt cattgacgcc ctgctgatat tgaccgacaa agtcggcgac
1815661 ccttggggtc gtcccttgcg cgatggaagc tagcgggcgt caacgtcgct acgccgcggc
1815721 cggttcggtc gtgctattgg ccggcgcgct tggctacatc ggacttgtcg acccgcacaa
1815781 ctcgaattcg ctatatccac cgtgcctatt caagttgctt acgggctgga actgccccgc
1815841 gtgcgggggt ctgcggatga tccacgatct gctacacggt gagctggcgg ccagcatcaa
1815901 cgacaatgtc tttctgcttg tcggcgtccc agtgctggcc agttgggtcc tgctgcgccg
1815961 ccgccacggc gacttggcgc tcccgatacc ggtgatgatt gctgtggcgg tcgcggtgat
1816021 cgcgtggacg gtgctgcgca acctgccagg cttcccgtta gtgccgacga tcagcggata
1816081 gccgcgccta cccgcggtct ggttggctgg gctgcccgcg gtggtgttga ccggtgtgcc
1816141 gacccggcgg tgccggccct accgccgtcg cgactatgct gagtcgtcgt gacgagacgc
1816201 gggaaaatcg tctgcactct cgggccggcc acccagcggg acgacctggt cagagcgctg
1816261 gtcgaggccg gaatggacgt cgcccgaatg aacttcagcc acggcgacta cgacgatcac
1816321 aaggtcgcct atgagcgggt ccgggtagcc tccgacgcca ccgggcgcgc ggtcggcgtg
1816381 ctcgccgacc tgcagggccc gaagatcagg ttgggacgct tcgcctccgg ggccacccac
1816441 tgggccgaag gcgaaaccgt ccggatcacc gtgggcgcct gcgagggcag ccacgatcgg
1816501 gtgtccacca cctacaagcg gctagcccag gacgcggtgg ccggtgaccg ggtgctggtc
1816561 gacgacggca aagtcgcatt ggtggtcgac gccgtcgagg gcgacgacgt ggtctgcacc
1816621 gtcgtcgaag gcggcccggt cagcgacaac aagggcatct cgttgcccgg aatgaacgtg
1816681 accgcgccgg ccctgtcgga gaaggacatc gaggatctca cgttcgcgct gaacctcggc
1816741 gtcgacatgg tggcgctttc cttcgtccgc tccccggccg atgtcgaact ggtccacgag
1816801 gtgatggatc ggatcgggcg acgggtgccg gtgatcgcca agctggagaa gccggaagcc
1816861 atcgacaatc tcgaagcgat cgtgctggcg ttcgacgccg tcatggtcgc tcggggcgac
1816921 ctaggtgttg agctgccgct cgaagaggtc ccgctggtac agaagcgagc catccagatg
1816981 gcccgggaga acgccaagcc ggtcattgtg gcgacccaga tgctcgactc gatgatcgag
1817041 aactcgcggc cgacccgagc tgaggcctcc gacgtcgcca acgcggtgct cgatggcgcc
1817101 gacgcgctga tgctgtccgg ggaaacctcg gtagggaagt acccccttgc tgcggtccgg
1817161 acaatgtcgc gcatcatctg cgcggtcgag gagaactcca cggccgcacc gccgttgaca
1817221 cacattcccc ggaccaagcg tggggtcatc tcgtatgcgg cccgtgacat cggcgaacga
1817281 ctcgacgcca aggccttggt ggccttcact cagtccggtg ataccgtgcg gcgactggcc
1817341 cgcctgcata ccccgctgcc gctgctggcc ttcaccgcgt ggcccgaggt gcgcagccaa
1817401 ctggcgatga cctggggcac cgagacgttc atcgtgccga agatgcagtc caccgatggc
1817461 atgatccgcc aggtcgacaa atcgctgctc gaactcgccc gctacaagcg tggtgacttg
1817521 gtggtcatcg tcgcgggtgc gccgccaggc acagtgggtt cgaccaacct gatccacgtg
1817581 caccggatcg gggaagatga cgtctagccg ggtcgtgccg gacggtaaac ccatgtccga
1817641 cttcgatgaa ctactggcgg tattggacct caacgccgtc gcaagcgacc tgttcaccgg
1817701 atcccacccc agcaaaaacc cgctccggac atttggtggc cagctcatgg cgcagtcatt
1817761 cgtcgcgagc agccgaacgc taacccgcca ccacctaccg cccagcgcat tctcggtgca
1817821 cttcatcaac ggcggtgaca cggccaagga catcgagttc caggtgatac gactgcgcga
1817881 tgagcggcgc ttcgccaacc ggcgcgtcga tgcggtacag gacggcacgt tgctgtcctc
1817941 ggcgatggtg tcttacatgg ccggtggtcg cgggcacgag catgcgctgg atccgccgca
1818001 ggtggccgag cctcataccc ggccgccgat cggtgagctg ttgcgcggtt acgaggagac
1818061 cgtcccgcat tttgtcaacg cgctgcaacc gatcgaatgg cgctacgcca acgacccggc
1818121 ctggataatg cgggacaagg gcgatcggct tgcctacaac cgggtctggg tcaaggcact
1818181 aggggagatg cccgacgacc cggtgctgca cacggcgaca ctgttgtact cctcggacac
1818241 caccgtgctg gactcggtca ttaccaccca tggtctgtcc tggggcttcg atcgcatctt
1818301 tgcggcctct gccaaccact cggtgtggtt tcaccggcag gtcaacttcg atgattgggt
1818361 gctctactcg acgtcgtcac cggtggccgc cgattcacgt gggttgggtt cggggcactt
1818421 ttttgatcgc tcggggaagc tcatcgcaac tgtggtgcag gaaggtgtgt tgaagtattt
1818481 tcccgccacc cctgacagtg cggcaggacg ctcgtaggat tccgggtcag cacggctgtg
1818541 atcaggcgta acgttcctgg tagccagatg accgatggtg gcagcggccg gcgagccgct
1818601 gaattgccag cgagcgaacc cggaggtgac tgtgaagctg ccgtcggccg atgtggtacc
1818661 gaggctccgt ggtcgccagc gtgtagtcgt gcacgtcgat tcccgcacgg cccgctgtgt
1818721 cggcgcgctg gcgctggtgt gcgcggcctg ctggctgatc gcgctgctcg ccggcgacta
1818781 ccggcacgcc cagtgggcgg tcgccggccg gttgggctgg tcgctgacgg tcctggctgc
1818841 ggtggcattc attgctcgcg gcatcttcct gggccgcccg gtcacggcca tgcatgcgac
1818901 cgcggccggc ctatttttgc tcgccggact ggctgcccac gtgttggtcg cagatctgct
1818961 cggtgagatt ctgatagccg gttcgggatg ggcactgatg tggccgacgt cggcgcatcc
1819021 gcgacccgaa gatctgcccc gcgtgtgggc gttgatcaat gccacccgcg cggactcgct
1819081 tgctccgttt gccatgcagg cgggcaagag ccatcacttc agcgcggccg gcaccgcggc
1819141 tctggcgtat cggacccgta tcggctatgc ggtggtcagc ggcgacccga tcggcgacga
1819201 ggcgcaattc ccccagctgg tcgccgactt cgcggccatg tgtcacatgc acggctggcg
1819261 aatcgtggtc gtgggctgca gcgaacgacg gctcggcctg tggagcgacc ccatggtggt
1819321 cggacaatcg ttgcggccca taccgattgg ccgggatgtc gtcatcgacg tgtctaactt
1819381 tgagatgacc gggcgtaggt ttcgcaacct gcgtcaggcg gtgaaacgca cccacaattt
1819441 cggcgtcacg accgagatcg tcgctgaaca gcaactcgac gaccagcggc aggcggagct
1819501 ggccgaggtg ctggcggcgt cacctagcgg cgcccgcacc gatcgcggct tttgcatgaa
1819561 cctggacggc gtgctggagg gtcgataccc cggaatacaa ctgatcatcg cgcgagacgc
1819621 atcgggtcgg gtgcagggtt tccaccggta cgcgaccgcc ggcggcggca gcgacatgtc
1819681 tctggatgta ccgtggcggc gccgcggggc cccgaacggg atcgatgagc ggctcagcgc
1819741 tgacatgatt gcggccgcca aagatgctgg ggtacaacgg ttgtcactgg cattcgccgc
1819801 gttccccgac cttttcggcg ccaaccagct cggccgcctg cagcgtgtct gccgtgcgtt
1819861 gatccatatc ctcgatccgt tgatcgctct cgagtcgtta taccgatacc tgcgcaagtt
1819921 ccacgcgctg gatgagcggc gttacgtgct gatatcgatg actcaggtct ttgcgctggc
1819981 gttggtgttg ttgtcgctgg agttcgtccc gcggcggcga catctctgat ccgtcgctat
1820041 ggacagctcg gcgcattgaa tgtcgttggg caggtggtgg gtggctacca ccacggtccg
1820101 catagcgctc atgatcccgg agttcggggc cagcagatcg cgcagaaggt cggcgttggc
1820161 ggcgtcgagg tgttcgacag gttcgtcgag caacacgatc cgagccgggg aaagcaccgc
1820221 ccgggcgagc agcaaccttc tgcgctgacc cgccgagacc gcttgcgcgc caccgatcaa
1820281 caccgtcgac aacccctcgg gcaggccggc gagccagccg cacaggccga cccgatccag
1820341 ggcctcgatc agttcgtcat cggggcagtc tcctcgggcg gtcagcaagt tgtcccgaac
1820401 ggtggtagca aagatatgcg catcttcagc gaaaaagctg acagcgctgc gtaattcatc
1820461 ctcatcgaag tcgctcaggt tagttccgtc cagcaacacc cggccgtgca ccggcggcag
1820521 caagccggcc agcgtcatca acagcgtcgt cttgccggcg ccgctcgcgc cggtgacggc
1820581 cagccgggca cccggcggta ggtcaatcgt cacccggatc gactgcgcct cttggtgacc
1820641 gcaacacacg tcggccgcta gcaccccggt acctaccggc agtcgcgccg acaccgtgga
1820701 ttcggtctcg cggacccggt ttgacccagt caggtcgagc agacgagccg ccgcgatgcg
1820761 cgaccgtgtc aactggacgg cggcggcggg tagtgcaacg gtcgcctcga atgcggacag
1820821 cggcaacaac atcaggatgg ccagtgttgt gggcgcgacc gtgggggcca tgccgatccc
1820881 ggccaccacg gcgcccagca ggctggcccc gatcgccgcg gtcggcatgg cctcggcgat
1820941 cgcccccgtt cgtgcggcgg cgtcgagcgc atcggcccag gcatgttggc gccgttgtga
1821001 gtcggcgatg acgttgcgta gggcaccggc gacacgaagc tcgggggcat gctcaagggc
1821061 gatcatcgcc gacgtgtcgc gcatgccccg atgttggcgg gcgatcgctt cctgcgctgc
1821121 ggcggttctg ccggcaagcc agggcgcaac aacgccggca accaaaaggc agaccgccag
1821181 taccacggcg gctggcaccg aaacggccgc gacgaccgcg gtcgcggcta ctgccagcac
1821241 cgctgcgacg gctatcggca ccagagcacg caccagcatg ttggccagtt cgtcgacgtc
1821301 cgcgccgacg cgtgctgcca ggtccccgct gtgcagcccg acggcggccg ccgccggtcc
1821361 gtgggccagc cggtgataga taagggtgcg ggcccggccg gcggcccgca acgcggtgtc
1821421 gtgggtggcc agtcgctcgc agtagtgcag cacgccgcgc gaaatcgcga acgcccgcac
1821481 cgccacgacc gccaccgaca ggtccaggac gggcggcatc tgccaggccc gagtgatcag
1821541 ccaggccgac accccggcca gggccagcgc gctgcccagc gacagcacgc ccagcgcgac
1821601 ggccgccaag atccggggca accggggacc caacagccca gacgcggcca gcaggtcccg
1821661 ctggcggcga ctcacagcac tcggtcggtt catcgtcgga aaccatccga gttcacttcg
1821721 acgacccggt caccggccgc ggcgacctgc tggcgatggg cgacgaccag caccgtcgca
1821781 cccgcgcggg cacgctcgac aatggcgccc aacacgtgtt gttcggtgcg ggcgtccagg
1821841 tgcgcggtgg gctcgtcgag cagcagcacc gcagccggtg atccgagcgc gcgggccagg
1821901 cccagccgtt gccgctgccc cagggataac ccgacaccac cgcgccccag cacggtatcc
1821961 agcccgcggg gcaactcgtc tagtacagcg tcgaatccgg ctgctgcgca ggcacgctcg
1822021 agatcatcca cagggcccag cagaaccagg ttgtggcgga cggttcctgg gaccagcacc
1822081 ggccgctgcg gcagccacga cagttgccgc caccaggcag ccggtgccag gttggtgacg
1822141 tcgactccgg cgaccgtgat tcgtcctgac gacggtgcgg tgagcccggc gatcgcttgc
1822201 agcgtagtgc tcttgccggc gccgtttcgg ccggtcagca ccgtcacccg accgggttcg
1822261 atgtctgcgg tgagatcata cggtgcgcgg ccgtcgcggc ctctgacact gagtctctcc
1822321 aggcgaatca ccccgccgcg cgcggtgacc gttcgtcggc cgggtgttgg tgagggtgac
1822381 tcgccgagga gggcgaatgc cttgtcggcc gcggttctgc cgtcagctgc ggcatgaaac
1822441 tggaccccaa cgcgacgcag cggccagtac acctccggcg ccaatagcag caccgtcaaa
1822501 ccggccgtca ggctcatctc cccgaagacc agccgtagcc cgatgcccac cgcgaccagg
1822561 gccacgccca gcgtggccag caattcgagc accagggccg acaagaacgc gatccgcagc
1822621 gtcgccatcg ccgaccgccg gtggtcagca gacagttccg cgatgcgttg ttccgggccg
1822681 gaagcacggc ccagcgcccg cagggtgggg atgccggcaa tcaggtctaa caaccgggcc
1822741 tggacggcgg tcatggccgc cagcgcggcc gccgaggggt tagtggtagc cagcccgatc
1822801 agcaccatga agatcggtat caggggcagt gtgatcacca caatggccat tgacttcaag
1822861 tcatagagcc cgatcacggc gacggtggcc ggggtcagga tcgcggccag cagcaacgtg
1822921 ggcaaatagc cggtgaagta gggccgcaag ccgtccaggc cccgggtaat cagcaccgcg
1822981 gcggcgtctc gctgcgcagc cagttggctg ggtcggcggg cggttaccgc ggtcagcacc
1823041 tgaccggaca ggtcggcgat cactgcgctg gcgccgcgct gggccaggcg cgcttgtagc
1823101 cactgaatcg acgcacgcaa cccccacagc accaacagga ttgacagtgg ccctagccaa
1823161 cgacgcaggc cagccatccc agggttggcg gggtcgatga cgccggcgac gatgcttgcc
1823221 aacacgatcg ccgagccgat ggcgcagccg gagatcccga ccccgcaggc caccgtgctg
1823281 agtagatagc ggcgcagcgc cgccgatgcc tgccacagcc gcggatccag gggcgcccgg
1823341 gttccccggg ccttggtgct cagggcgcgc gcctcgccag accggtgggt ggaggtatcc
1823401 gttcagctga gatccgttgc cggaaaaccc aatacgtcca tgtctggtac gccaccgtca
1823461 gtggagcgaa gaacgcggtc acccacgtca tgatcttgag ggtgtacggg gtcgacgacg
1823521 cgttatggat cgttaggctc cactgcgggt tcagggttga gggcaccagg ttcgggtaca
1823581 gcgcgccgaa cagcagcacc accacagccg ccacgactat caacgtgcac atgaacgccc
1823641 agccgtcgga cacccgccgc cacactaaga ccgtcgccgc cgcctgcgcg caccccgcaa
1823701 ctgccagcac cagccacgtc cagtctttgc cgtatgccag ttgcgtccaa agtccaaagc
1823761 ccgcaaccag tcccgccaca ggaagcgaaa gccatacggc gaatcggtag gcatcgtcgc
1823821 ggatcggccc ggaggttttc aaagcgatga acaccgcgcc gtagagcgag aacagtccgg
1823881 cggtcgccag accgcccagc agggtgtagg cgttgagcac gtcgggaatc gacagggcaa
1823941 catgaccgtt cgcgtctacc gggagtccgc ggaccagaat ggcgaacgcc acaccccaca
1824001 acagggcagg cagccaggat cccgccgcga tcccgaagtc tgccccggtc cgccatttcg
1824061 ggtcgtcgat cttgccgcgc cattcgatgg cgacggcgcg caggatcata ccgaacagga
1824121 tcgccagcag cggcagatac agcgcggaga acacggtcgc gtaccagccg ggaaacgcgg
1824181 cgaatatggc cgcgccggcg gtgatcagcc agacttcgtt gccgtcccag accggtccga
1824241 tggtgttgag tgccgtgcgc cggtgggtct ccggatcgcc cataccgaca tgagcgaacg
1824301 gcgccatcag catgcccacg ccgaagtcga acccttctag gatgaagaaa ccgaggaaca
1824361 gcgctgcgat gacaccgaac cacaattctt ggagtaccac cggctgctcc tttccggggt
1824421 cagttggcct cagtaagcaa acgacaatgg tgctacctcg tcgtcgcggg gtgccccgtg
1824481 cgcagccggt tccgcgtcgt gttccagggg gccttcgacg atgtaacgct tgagcagcca
1824541 gcaccagatg accgcaagta ccgcgtagac caaggtgaac atcagcaaag acgtggcgac
1824601 cacggtggcg gagtgatccg agacgcctgc tttgacggtg agtcgaacca gctgatcacc
1824661 ggtcgggtta gggacgacga cccagggctg gcgccccatc tcggtgaaca cccatccggc
1824721 gctgttggcc aggaacgggg cgggcatggt tagcagcgcc agccaggaga accagcgttg
1824781 attggggatc tggccgccac gggtgagcca gagcgcaatc agtgcgaaca gcaccgggat
1824841 cgccatcaac ccgatcatca tgcgaaatga ccagtaggtg acgaagaggt tgggccggta
1824901 gtcgtttggt ccgaagcgct gctggtattc ctgctgcaga tcgcggatac cctgcaacgt
1824961 cacaccgctg atccggccct cggcgaggaa cggcaacaca tagggcactt cgatgacacg
1825021 ggtgaggctg tcgcagttgt tttgccggcc gaccgtcagg acagagaagt ttggatctgt
1825081 ctgggtatcg cacaacgatt cggccgacgc catcttcatc ggctgctgct ggaacatcag
1825141 cttgccttgg tggtcgccgg tgaacaacaa cccggccgtg gcggccaacg caacccaaca
1825201 ccccaggatg gtcgcgggac gatacatggc ttgggtatct gagtcggcgt gcgtggtgct
1825261 cgaacggacc agccaccagg cgctcaccgc ggcgacgaag gtcccggcgg tcagcagcgc
1825321 accgctgaca gtgtgggtaa acgccgcctg tgcggtgttg ttggtcagca gcacgacgat
1825381 gctgctcaac tcggcacgcc cggtggtcgg gttgtagtgc gcgccgaccg gatgctgcat
1825441 gaaggagttt gccgcgatga tgaagaacgc ggacacgttg accgcgattg cgacgatcca
1825501 gatgcaggcc agatgcacca gccggggcag cctgttccag ccgaagatcc acaacccgat
1825561 gaaggtggat tcgaagaaga aggccgccag gccctccatg gccagcgggg cgccgaagac
1825621 atcgccgacg aatcgggagt actcgctcca gttcatgccg aactgaaatt cctgcacgat
1825681 tccggtcgcc acgccgatgg caaagttgat caggaacaat ttgccgaaga atttggtgag
1825741 gcgataccag gcggggttat cggtgacgac ccacagcgtt tgcatgaccg cgatcagcgg
1825801 ggccaggccg atggtcagcg gtacgaaaat gaagtgatag acggtggtga taccgaactg
1825861 ccaccgcgaa atgtcgacga cattcatctg tcatctccgg agatactacg gggccgactg
1825921 atttggctac gacgaagtgt agtaggcacg agtgggcccg cgctactggc aatcgtgggt
1825981 gcaccgcgat tctgcggtca gccgagcgtc tgcgaagcct tgcggatggc gaacgacgac
1826041 gcgatctcgc atgtgccgat caccacgagc cagatgccga cgaccaacgc cagtatccag
1826101 atggactcga acggcgatgc catcaccaca atgccggcga tgaggctgat cacgccgacg
1826161 aagatggacc atccccgtcc cggcagcatc ggatcactaa tcgccgaaac cgtggtggcg
1826221 acgccgcgga agatgaaccc gatgccgatc cagatggcca gcaacagaac cgcgtcaccg
1826281 aaatggcgaa aggccagcac agccaggatg agtgaggcgg caccgctgat gaacaacagg
1826341 atccggccgc ccgccgaaac atgcaggctg aacgcgaacg caacctgagc gacaccggta
1826401 atcaggaggt agacaccgaa cgccatggca gcaacgagaa tggatattcc tggccaggcc
1826461 agcaccagga cgcccaggat cagcgacaga attcccgatg ccagagtgga cttccagaga
1826521 tgcggcaaca accttgggag agggctcacg acagggcttg gttccatggg cgcagtgtga
1826581 cacatgtagc ggccccggga tagcgcttgg cggtcagacc cctgccgtgc ggggttcggc
1826641 cccgcgcacc tcgccgggat ctgcggctac cttgcggccg atgaggtacc acgtgcgcat
1826701 tacgcctttc cccttgacgt ttatgtggcc gcgctcgcgc aacacgaagt cgtccttgag
1826761 acgctcgtaa acctcgtctg gcacctgaat ttgccccacc gaatcggtgg attccatccg
1826821 cgacgcgaca ttgaccgcgt cgccccacac gtcgtagaag aaccgtcgag aacccaccac
1826881 acccgccacc accgggccgg tggccaggcc cacccgcagc ggcaccgggt tgccgcgtgg
1826941 atccttcaat tgcgctgcga cattggtcat gtcgagcgca aagtccgcca gtgcttgcgt
1827001 atggtcaggc cggggccgcg gaacgccgct gacaaccatg taggagtccc cgctgacctt
1827061 gattttctcc agcccgtgct ggtcgaccag ctcgtcgaaa gcgctgtaga ggcggtccag
1827121 gaaccggacc aggtccgccg gcgcggtgct actggcgcgt tcggtgaacc cgacgatgtc
1827181 ggcgaacagc accgaggcct cgtcgtattt atcggcgatg atgtttcgct cgggttcttt
1827241 aagccgctcg gcgatgctgg ccggcaacat gttggccagc agtgcttcgg agcggtcgtg
1827301 ctccgcctcc atgaccgcct ccgcgcgcgc agtatcacgc agcgcgaacc acaccgttgc
1827361 gaccgctacc ccgcaggcgg agacggtcgt gaggacgaaa cttaccgaca tggcccaggg
1827421 cggctgaagc ccagtatcgg gcgggaccag gaactccagg gcaatcacca gaccggcggc
1827481 gaccgccgct aggcccaccg ctaacgcggt gtgttcgatg ccgaccagca acaccaccaa
1827541 cgcggcggct accaagaaga agaactgggc acccgcgtcg gtgcccacat cccagccgat
1827601 ggcgaagatc gccacatagg cggtgccgat gaacgtaagc ggtgccacca atcccccgaa
1827661 gcgatgtagc aggggcacga tcgcgaaagt aaccgcggtg aagacgttga tcagggcgat
1827721 gtaccagccc ccggccccgg tcgctagttg cattagcgcg aagctcccgg ttaccacgac
1827781 agcgagccag gcggtgatgg taagcacgcg ctgccgccgc gcgacgcttt cggcgtagtg
1827841 ctgcgtggga gcgcgggcct gagtgcgcac ggccgtgaca cagtctgggc gtcgtgtcga
1827901 gccatccgct gctatcggtg gggcgccgca ttttcttgcc gccacgaact aaagcctaat
1827961 cggtgagtta gcgtttaccg actctgtcgg cgctttccgg gtgcgttcgc ttggtgccct
1828021 cggtgggatt cgaacccaca ctggacgggt tttgagtccg tttcctctgc cagttgggat
1828081 acgagggctt gatccggtct cctactctag aggagccacg tcccgactca ccgccccccg
1828141 aggttcccga tcgcgcccgc tcacgacaca atgtccgtca tgaccggccc caccaccgac
1828201 gccgatgccg ctgtcccacg tcgggtcttg atcgcggaag atgaagcgct catccgcatg
1828261 gacctggccg agatgttgcg agaggaggga tatgaaattg tcggcgaggc cggcgacggc
1828321 caggaagccg tcgagctggc cgagctgcac aagcccgacc tggtgatcat ggacgtgaag
1828381 atgccgcgcc gggacgggat cgacgccgca tccgaaatcg ccagcaaacg tattgccccg
1828441 atcgtggtgc tgaccgcgtt cagccagcgt gatctggtcg aacgtgcgcg tgatgccggg
1828501 gcgatggcat acctggtaaa gcctttcagc atcagcgacc tgattccagc gattgaattg
1828561 gcggtcagcc ggttcaggga gatcaccgcg ttggaaggcg aggtggcgac gctatctgaa
1828621 cggttggaaa cccgcaagct ggtggaacga gcaaaaggcc tgctgcagac caaacatggg
1828681 atgaccgagc cggacgcttt caagtggatt caacgtgccg ccatggatcg gcgcaccacc
1828741 atgaagcggg tggccgaagt cgtgctggaa accctcggaa cacccaaaga cacctgaggg
1828801 cgagcagacg caaaatcgcc catttcgtac ccgaaatggg cgattttgcg tctgctcgcg
1828861 gaacctagcg cgcgacgatc accgacgagc cgtgcccgaa caggccctgg ttggcggtga
1828921 cgccgacctt ggcgtccgcc acctgccggc cggtggcctg accgcgcagc tgccaggtca
1828981 gctcgcagac ctgcgcgatc gcctgggcgg gaatcgcctc accgaaacac gccagcccgc
1829041 ccgacgggtt gaccgggacc ctgccgccga gggtggtcgc gccgctgcgc agcagcgcct
1829101 cggcctcacc cttggggcag agccccaggt gttcgtacca gtcgagttcc aacgcggtgg
1829161 acaggtcgta gacctcggcc aggcttaagt cttctggacc aataccggcc tccgcgtagg
1829221 cagcgtcgag gatctgatcc ttgaacaccc gctccggagc cggcaccgcg gcggtggaat
1829281 ccgttgcgat atccggcaat tcgggcaaat gttgcgggta tttcggggta acggtgctga
1829341 tcgcgcgcac cgacggcacg cccgccaccg agccaaggtg cttctcggtg aaagacttgc
1829401 tggccacgat gagtgcggcc gcaccgtcgg aggtggcgca gatgtcaagc agccgaagcg
1829461 gatccgagac caccgggcta gccagcacgt cgtcgatcga gttctctttg cggtagcggg
1829521 cgttcgggtt gtctaggccg tgccgggagt tcttgacctt cacttgagcg aagtcctcga
1829581 ctgtggcgcc gtacaggtcc atgcgccggc gcgccagcag cgcgaagtac accgtgttcg
1829641 tcgccccgat cagatggaag cgctgccagt cggggtcgcc cttgcgctcg ccgcccacgg
1829701 gcgcgaaaaa gcccttcggt gtggtgtcgg cgccgatcac cagcgccacg tcacagaaac
1829761 cggccaagat ctgcgcgcga gcactctgca gcgcttggga accgctggca cacgcggcgt
1829821 agctggagct gaccggcaca ccggtccagc cgagcttctg ggcgaacgtg gcaccggcga
1829881 cgaagcccgg atacccgttg cggatggtgt ccgctccggc gaccagctgc acgtgccgcc
1829941 agtccacgcc ggcgtcccgc aacgcggcgc gggcggcgac cacgccatac tcggtgaagt
1830001 cattacccca tttcccccac gggtgcatac cggcacccag gatgtaaacg ggttccggcg
1830061 cgctcatcct catcggcgcc gctcctcagc atcgctgcgc tctgcatcgt cgccggcgcg
1830121 cgatgggatc cgccacgcgt agacgatgcg ctgcacaccg tcgtcgtcgg cgaacagcgg
1830181 catggtcgtc agctccatct ccatgccgac cttcagatcg gcggccagcg tgccatcgac
1830241 cactttgccc agcacgatca gtccctcgtc ggccagttcc accgcggcca cggcgaacgg
1830301 ctcaaagggg tcgggtgccg ggtacggcgg tggcggggcg taccggtttt cggtgtagct
1830361 ccaaagcttt ccgcgggtcg acagtccgac cgactctagt gtgtcgctgc cgcaagccgg
1830421 attcggacaa ttgtccgccc ggggtgggaa gacgtacgtg ccgcactggg gacacttgcc
1830481 gccgagcaga tgcgggttgc cggccttatc ggtggtgaac catccatcga ttgccggttc
1830541 ttcacgggtg acctctggca ccggtccagc ctaccgagcc cgggcgtaaa actgaaacgt
1830601 gttgcagttc tgctggcacc tgcgcccgca ttccacgtca gcgtcggtgc ataaagtgtg
1830661 agccgtggtg actactgcca gtgcccccag cgaggatcga gccaagccga cgctgatgtt
1830721 gctggatggc aattcgctgg cgtttcgggc gttctacgca ctgcccgcgg agaacttcaa
1830781 gacccgcggc gggctgacca ccaacgccgt ctacggcttc accgccatgc tgatcaacct
1830841 gctgcgcgat gaagccccga cgcacatcgc ggcggctttc gacgtgtccc ggcagacctt
1830901 ccgcttgcaa cgctacccgg agtacaaggc caaccgatcg tcgacccccg acgagttcgc
1830961 tggccagatc gacatcacca aagaagtgct gggcgcactc ggcatcaccg tgctctccga
1831021 gccggggttc gaggccgacg acctcatcgc cacgctggcc acccaggccg agaacgaggg
1831081 ctaccgggtg ctggtggtca ccggggatcg tgacgcactg caactggtca gtgacgatgt
1831141 gacggtgctc tacccccgca agggcgtcag cgaacttacg cgcttcacac cggaggccgt
1831201 cgtcgaaaag tacgggctca cccctaggca gtacccggac ttcgccgcgc tgcgcggcga
1831261 ccccagcgat aacctgcccg gcatacccgg ggtgggggag aagaccgccg ccaaatggat
1831321 cgccgagtac ggctcgctgc ggtcactggt ggacaacgtt gacgccgtgc gcggcaaggt
1831381 gggcgatgcg ctgcgggcga acctggccag cgtggtgcgc aaccgtgagc tcaccgacct
1831441 ggttcgcgac gtgccgctgg cccagacccc ggacacgctg cggctgcagc cctgggatcg
1831501 cgaccacatt caccggctct tcgacgacct ggagtttcgg gtgttgcgcg accggttgtt
1831561 cgacacgttg gccgcggccg ggggacccga ggtcgacgag gggttcgacg tgcgcggcgg
1831621 cgcgttggcg cccggcacgg ttaggcaatg gttggccgag cacgccggcg acgggcgccg
1831681 agcgggcctg acggtggtgg gtacccatct gccgcacggt ggggacgcta ccgctatggc
1831741 cgtcgccgcc gccgacggcg aaggcgctta cctcgatacc gcgacgctga cgcccgacga
1831801 cgacgccgcg ttggcggcct ggctagcgga tccagctaaa cccaaagcct tgcatgaggc
1831861 aaaggcggcc gttcatgacc tggcgggtcg tggttggacc ttggagggcg tcacctccga
1831921 caccgcactg gcggcctacc tggtgcggcc ggggcagcgc agcttcaccc tcgacgacct
1831981 ctcgctgcgc tatctgcgtc gcgagctgcg tgcggaaaca ccgcagcagc aacaactttc
1832041 actgctcgat gacgacgata cggacgccga gaccattcaa acgacgatcc tgcgggcgcg
1832101 ggcagtcatc gacctggccg acgcgctgga cgccgagtta gcgcgtatcg actccaccgc
1832161 gctgctgggg gagatggagc tgccggtcca gcgggtgctg gcgaagatgg aaagtgccgg
1832221 tatcgccgtc gacctgccca tgttgaccga gctgcaaagc cagtttggcg accagatccg
1832281 cgacgccgcc gaggccgcct acggcgtgat cggcaagcaa atcaacctgg gctcacccaa
1832341 gcagctgcag gtcgtgctgt tcgacgaact gggcatgccg aagaccaaac gcaccaagac
1832401 cggctacacc acggatgccg acgcgctgca gtcgttgttc gacaagaccg ggcatccgtt
1832461 tctgcaacat ctgctcgccc accgcgacgt cacccggctc aaggtcaccg tcgacgggtt
1832521 gctccaagcg gtggccgccg acggccgcat ccacaccacg ttcaaccaga cgatcgccgc
1832581 gaccggccgg ctctcctcga ccgaacccaa cctgcagaac atcccgatcc gcaccgacgc
1832641 gggccggcgg atccgggacg cgttcgtggt cggggacggc tacgccgagt tgatgacggc
1832701 cgactacagc cagatcgaga tgcggatcat ggcgcacctg tccggggacg agggcctcat
1832761 cgaggcgttc aacaccgggg aggacctgca ttcgttcgtc gcgtcccggg cgttcggcgt
1832821 gcccatcgac gaggtcaccg gcgagctgcg gcgccgggtc aaggcgatgt cctacgggct
1832881 ggcttacggg ttgagcgcct acggcctgtc gcagcagttg aaaatctcca ccgaggaagc
1832941 caacgagcag atggacgcgt atttcgcccg attcggcggg gtgcgcgact acctgcgcgc
1833001 cgtagtcgag cgggcccgca aggacggcta cacctcgacg gtgctgggcc gtcgccgcta
1833061 cctgcccgag ctggacagca gcaaccgtca agtgcgggag gccgccgagc gggcggcgct
1833121 gaacgcgccg atccagggca gcgcggccga catcatcaag gtggccatga tccaggtcga
1833181 caaggcgctc aacgaggcac agctggcgtc gcgcatgctg ctgcaggtcc acgacgagct
1833241 gctgttcgaa atcgcccccg gtgaacgcga gcgggtcgag gccctggtgc gcgacaagat
1833301 gggcggcgct tacccgctcg acgtcccgct ggaggtgtcg gtgggctacg gccgcagctg
1833361 ggacgcggcg gcgcactgag tgccgagcgt gcatctgggg cgggaattcg gcgatttttc
1833421 cgccctgagt tcacgctcgg cgcaatcggg accgagtttg tccagcgtgt acccgtcgag
1833481 tagcctcgtc aggtaccaat ctgtccctac gacccaaccc tgtccggagc aacccaacaa
1833541 tatgccgagt cccaccgtca cctcgccgca agtagccgtc aacgacatag gctctagcga
1833601 ggactttctc gccgcaatag acaaaacgat caagtacttc aacgatggcg acatcgtcga
1833661 aggcaccatc gtcaaagtgg accgggacga ggtgctcctc gacatcggct acaagaccga
1833721 aggcgtgatc cccgcccgcg aactgtccat caagcacgac gtcgacccca acgaggtcgt
1833781 ttccgtcggt gacgaggtcg aagccctggt gctcaccaag gaggacaaag agggccggct
1833841 catcctctcc aagaaacgcg cgcagtacga gcgtgcctgg ggcaccatcg aggcgctcaa
1833901 ggagaaggac gaggccgtca agggcacggt catcgaggtc gtcaagggtg gcctgatcct
1833961 cgacatcggg ctgcgcggtt tcctgcccgc ctcgctggtg gagatgcgcc gggtgcgcga
1834021 cctgcagccc tacatcggca aggagatcga ggccaagatc atcgagctgg acaagaaccg
1834081 caacaacgtg gtgctgtccc gtcgcgcctg gctggagcag acccagtccg aggtgcgcag
1834141 cgagttcctg aataacttgc aaaaaggcac catccgaaag ggtgtcgtgt cctcgatcgt
1834201 caacttcggc gcgttcgtcg atctcggcgg tgtggacggt ctggtgcatg tctccgagct
1834261 atcgtggaag cacatcgacc acccgtccga ggtggtccag gttggtgacg aggtcaccgt
1834321 cgaggtgctc gacgtcgaca tggaccgtga gcgggtttcg ttgtcactca aggcgactca
1834381 ggaagacccg tggcggcact tcgcccgcac tcacgcgatc gggcagatcg tgccgggcaa
1834441 ggtcaccaag ttggttccgt tcggtgcatt cgtccgcgtc gaggagggta tcgagggcct
1834501 ggtgcacatc tccgagctgg ccgagcgtca cgtcgaggtg cccgatcagg tggttgccgt
1834561 cggcgacgac gcgatggtca aggtcatcga catcgacctg gagcgccgtc ggatctcgtt
1834621 gtcgctcaag caagccaatg aggactacac cgaggagttc gacccggcga agtacggcat
1834681 ggccgacagt tacgacgagc agggcaacta catcttcccc gagggcttcg atgccgaaac
1834741 caacgaatgg cttgagggat tcgaaaagca gcgcgccgaa tgggaagctc ggtacgccga
1834801 ggccgagcgc cggcacaaga tgcacaccgc gcagatggag aagttcgccg ccgccgaggc
1834861 ggctggacgc ggcgcggacg atcagtcgtc ggccagtagc gcaccgtcgg aaaagaccgc
1834921 gggtggatca ctggccagcg acgcccagct ggcggccctg cgggaaaaac tcgccggcag
1834981 cgcttgatct tgcagctgat cgcgttcacg taatgctgcg catcgggctg accggcggca
1835041 ttggcgccgg gaagtcgttg ctgtccacga cgttctcgca atgcggcgga atcgttgtcg
1835101 acggcgatgt gttggcgcgt gaagtggtcc agccgggcac cgaggggctg gcctcgctgg
1835161 tcgacgcgtt cggtcgcgac atcctgcttg cagacggagc gctggaccgg caggcgttgg
1835221 cggccaaggc gtttcgagat gacgagtcgc gcggtgtgct caacggaatc gtgcacccgc
1835281 tggtcgcccg gcgccgatcc gagatcatcg cggcggtttc gggggacgcg gttgtggtcg
1835341 aagatattcc actgctggtg gaatccggga tggcgccatt gtttccgctg gtggtggtgg
1835401 tgcacgccga cgtcgagcta cgggtgcgac ggctggtcga gcaacgcggc atggccgaag
1835461 ccgacgcccg ggctaggatc gctgcgcagg ccagcgacca gcagcgtcgt gccgtcgccg
1835521 acgtctggct ggacaactcg ggcagcccag aggatttggt gcggcgggcc cgcgacgtct
1835581 ggaacacgcg cgtccagccc ttcgcgcaca acctggccca acgtcagatt gcgcgcgcgc
1835641 cggctaggtt ggtgccggcg gatccaagct ggccggatca ggcgcggcgc atcgtcaacc
1835701 ggctaaagat cgcgtgcggg cataaggcct tgcgagttga ccacattggg tcaaccgccg
1835761 tgtcgggctt ccccgatttt ctagccaagg atgtcatcga catccaggtc accgtcgaat
1835821 cacttgacgt ggccgacgag ctggccgagc ccttgctggc cgccggctac ccacgcctcg
1835881 agcacatcac ccaggacacc gaaaagaccg acgctcgcag caccgtcggc cgctacgacc
1835941 acaccgacag tgccgctctg tggcacaagc gcgtgcacgc ctcggcggat cccggtcggc
1836001 cgaccaacgt gcacctgcgg gtgcacggct ggcccaacca acagttcgcc ctgctgttcg
1836061 tcgactggct ggcggccaat cccggcgcga gagaagacta tttgacggtc aagtgtgacg
1836121 ccgacaggcg cgccgacggt gagctcgcgc gctacgtcac cgccaaggag ccgtggttcc
1836181 tggatgccta ccagcgggca tgggagtggg cggatgcggt gcactggcgt ccctgaacga
1836241 gggcctgccg cactgggcga tgacgccatc gatcgagcag gccgcgcagc tgtcatcccc
1836301 ggccagcctc atctgaggct tccagctcgg gggcgccggc gcccggggcg gtgggcgctt
1836361 ctgctacccg agccggcacg cgcgcttcat gagccgctgc gccaggtcag ctccatcccc
1836421 ttggtggcca gccagcgggt gaggtcatag ccgttgcggg ccaggccctc gacggcgtcg
1836481 actgcgtgcc gcaccgcctg ctcggcgacc gtcggggtca acaggccgtg gcggacggcg
1836541 tcgagtagtt cgtcgacgtc ggcgagctcg gccccgccgc cggtgcggac ttcgatgtcg
1836601 aggtagtggt cttcggaacg ccatacggaa gggcccggtg tgtattcgcc gacgtccaga
1836661 tagtagtcgt gatcgcgttt gtggctggga ttgaagtgaa agacagtggc gcgtaggccc
1836721 aacgacggca acagccacga ctcgaggtag tggaattggg cacggcccgg ggtgggccgg
1836781 gccaggtaga gcccccacgg atgcaccgtg tactcatcga ccgcccgcac tatgcccttc
1836841 ggatcggtat tggtgtgggc gatcaggtcg aacgtctcgt gcttgggtgg gtgaatggct
1836901 caccctatct ggtcgcacga ggcgtgccgg tacatcgaca cgccggtact ggtggcattc
1836961 tgcgcacgct cgccgcacgg tgtgtccgcg ggtggctcta ggctggttgg cgtggctttc
1837021 gctaccgagc atccggtggt cgcgcattcg gagtatcgcg cggtcgagga gattgtgcgc
1837081 gccggcggtc acttcgaggt ggtcagtccg catgctccgg ccggcgacca gccggccgca
1837141 atcgacgagc tggagcggcg gatcaacgcg ggggagcgtg acgtggtgtt gctcggcgcc
1837201 accggcaccg ggaagtcggc gaccaccgcg tggctgatcg aacgcctgca gcggcccacc
1837261 ctggtgatgg cgcccaacaa gacgttggcc gcccagctgg cgaacgaact gcgagagatg
1837321 ttgccgcaca acgccgtcga gtacttcgtc tcgtactacg actactacca gccggaggcg
1837381 tatatcgcgc agaccgacac ttatatcgaa aaggatagct ccatcaacga cgacgtggag
1837441 cggctgcggc actccgcgac ctcggcgctg ctgtcgcgtc gtgacgtggt ggtggtggct
1837501 tcggtgtcct gcatctacgg cctgggcaca ccgcagtcct acctggaccg ctccgtcgag
1837561 ctgaaggtgg gcgaggaagt gccgcgcgat gggctgctgc ggctgctggt cgacgtgcaa
1837621 tacacccgaa acgacatgtc ctttactcgc ggctcgtttc gggtgcgcgg cgacaccgtc
1837681 gagatcatcc cctcctacga agagctggcg gttcgcatcg agttcttcgg cgacgagatc
1837741 gaggcgctgt actatctgca cccgctgacc ggcgaggtta tccgccaggt cgactcgctg
1837801 cggatctttc ccgctaccca ttacgtcgcc ggtccggagc ggatggcgca tgccgtctcg
1837861 gccatcgagg aagaactcgc cgagcgactc gccgagcttg agagccaggg caagctgctg
1837921 gaggcgcagc ggctgcggat gcgcaccaac tacgacatcg aaatgatgcg gcaggtcggg
1837981 ttctgctcgg gcatcgagaa ctactcccgc cacatcgacg gtagggggcc cggcacgccg
1838041 cccgcgaccc tgctcgacta tttccccgag gatttcctgc tcgttatcga cgagtcacat
1838101 gtcaccgtgc cgcagatcgg cggcatgtac gagggcgaca tctcccgcaa gcgcaacctg
1838161 gtggagtacg gtttccggct gccgtcggcg tgcgacaacc gtccgctgac ctgggaggag
1838221 ttcgctgacc ggatcgggca gacggtgtat ctgtctgcca ccccggggcc ctacgagctc
1838281 agccagaccg gcggcgagtt cgtcgagcag gtgatccggc cgaccggtct ggtggacccg
1838341 aaagtggtag tcaagccgac caaagggcag atcgacgacc tgatcggcga gatccgcaca
1838401 cgggcagacg ccgaccagcg ggtgctggtg acgacgctga ccaagaagat ggccgaagac
1838461 ctcaccgact acctgctgga gatgggcatt cgggtgcgct acctgcattc ggaggtcgac
1838521 acgttgcgcc gggtcgagtt gttgcgccag ctgcgtctgg gtgactacga cgtgctggtc
1838581 ggcatcaacc tgctccgcga gggcctagac ctgcccgagg tgtcgctggt ggcgatcctc
1838641 gacgccgaca aagaaggatt cctgcggtca agccgcagcc tgatccagac catcggacgc
1838701 gccgctcgca acgtgtccgg cgaggtgcac atgtacgccg acaaaatcac cgactcgatg
1838761 agggaagcca tcgacgagac cgaacgccgg cgggccaagc agatcgccta caacgaggcc
1838821 aacggaatcg acccacagcc gctgcgcaaa aagatcgccg acatcctcga tcaggtctat
1838881 cgggaggccg acgacaccgc cgtcgtcgag gtcggcggat ccgggcgcaa cgcatcccgc
1838941 ggccggcggg ctcagggtga gcccggccgg gcggtcagcg ccggcgtgtt cgagggccgc
1839001 gacacctccg ccatgccgcg cgctgagctg gccgacctaa tcaaagacct caccgcacag
1839061 atgatggcgg ccgcgcgcga cctgcagttc gagctggcgg cccggttccg cgacgagatc
1839121 gccgacctca agcgggagct gcgggggatg gacgcggccg gcctgaagtg accgaaacag
1839181 cgagcgagac cggcagctgg cgtgagctac tgagcaggta tctgggcacc tccatagtgc
1839241 tggccggtgg cgtcgcgctt tacgccacca acgagtttct gacaatcagc ctgctgccga
1839301 gcacaatcgc cgacatcggg ggtagccggc tgtacgcctg ggtgacaacc ctgtatctgg
1839361 tcgggtcggt ggtggcggcg accaccgtca atacgatgtt gctgcgcgtc ggggcgcgct
1839421 cgtcgtatct gatggggttg gccgtcttcg gtctggccag cctggtatgt gcggcggcgc
1839481 cgagcatgca gattctggtg gccgggcgta ccttgcaagg aatagccggt gggctgctgg
1839541 ccggcctagg ctacgcgctg atcaactcga ccttgcccaa gtcgctgtgg acccgtggct
1839601 cagcactggt gtcggcgatg tggggggtcg cgacgctgat cggaccggcg accggaggcc
1839661 ttttcgcgca gctcgggctg tggcgatggg cgttcggcgt gatgacgttg ctgaccgcgt
1839721 tgatggccat gttggtgccg gtcgcgctcg gtgccggggg ggtcggcccg ggcggcgaga
1839781 cgccggtggg cagcacacac aaggtgccgg tgtggtcgct attgctgatg ggggccgccg
1839841 cactggcgat cagcgtcgcc gcgcttccga actacctcgt ccagacggcc gggctgctag
1839901 ccgccgccgc gctgctggtt gcggtgtttg tggtagtcga ctggcggata cacgcagcgg
1839961 tgttgccgcc cagcgtattt ggctccggac cgttgaaatg gatttacctg accatgtcgg
1840021 tgcagatgat tgcggcaatg gtcgatacct acgtgccgct gttcggtcag cgactgggac
1840081 acctgacccc ggtggcagcc gggttcttgg gtgccgcgct ggcggtgggc tggacggtcg
1840141 gtgaggtcgc cagcgcctcg ttgaacagtg cacgagttat cgggcatgtc gtggcagccg
1840201 caccgctggt gatggcgtcg gggttggcgc taggcgccgt cacccagcgc gccgatgcgc
1840261 cggtggggat catcgcgctg tgggcgctgg cgctgctgat catcgggacc ggcatcggga
1840321 tcgcctggcc gcatctaacg gtgcgcgcta tggattctgt cgccgacccg gccgagagca
1840381 gcgcggcggc cgcggcgatc aatgtcgtac agctgatctc cggtgctttc ggcgccgggc
1840441 tggccggtgt ggtggtcaac actgccaagg gcggcgaagt ggcggcggct cgtgggctat
1840501 acatggcatt tacggtgctg gccgccgctg gtgtcatcgc ctcctaccag gccacgcacc
1840561 gcgaccggcg cttaccgcgt tgacttgacc acctgcgagt agtggaactg ccagcgctcg
1840621 acgatgcgga agccgaggta gctcgggaac cggtatacgg gcgtgcgccc gaagcctgtt
1840681 cccggtgaca acatttcgcc gacctgatga tcgggcaacg acttgtcacg attggctatc
1840741 gtccacagcg tggggcactt gtcgatcttg gccgtcgtaa gccacacagc gacatggcca
1840801 tcccacaaag tgccgacctt ggggccgtag gtgccgcgct cgacgtcaat cagcgaccgg
1840861 aacgccgccg gccgggtggc cagcagggcg cggatgggcc cgggtcgcca acccgcggtg
1840921 ttgtccacca gcaggcaatc cccgggcttg gcatgggcgc tgatgacatc tgccacctgg
1840981 ctgtaatccc agccctcttt cgcgtacggc ccccgctgtg tgaagaagta gttcggaaac
1841041 gctgcggcgg caaggagaaa cacgaccccg gcgatgagcc acggcttgcg ggcgatggtg
1841101 acgacgcaaa ccgccaggat gacggccgcg gcgggggcgg tgaggatcag gtagcgcggg
1841161 tagtagatcg gttcgacggt cgccgagtag atgaggacga cggcggtggg cacgacgatc
1841221 caggctgcgc tgacgagcac gagccggtgg gtatcgccac cgggtccacg agctccggcc
1841281 agatgcgccg cgatgccggc agcgacgatg aggcccgcga ggatggcgaa cggaacactg
1841341 tgatcgaaat actggcggtg tatgacgtcg agaatgatgt ttctgttcaa ccctgcgatc
1841401 cacccgacct gccaaacctg gccgtgggcg aacagtatga acggtgtcat ggccccgagc
1841461 gcggctgccg tgacgaccgt ccaccagatc acgggagatt tgcgtgattt cccggacgcc
1841521 agcagcggca ccatcgtcgc ataggccggt accaacaggg ccaggttgat actgaccaag
1841581 atcgacagca tcaaaaccag cgcgtagagc agccaccgcc gctgggtgtt gcaccgcacc
1841641 gcggccacga gtaatacggt cagccagacg gcggctgcta ccgacagcgc ggaggagcgt
1841701 gcttcgattc cggcccacgt caccctgggc agaatcgcga acacggctcc cgcacacacc
1841761 gccgtggtgc gtcccgaaaa ctgtttggca aaaaccacca cgccggcggc ggccgctcca
1841821 atggccaggc agctgggaag ccgcgaccat aattcggtgg gcggaaatat ggcgaaccag
1841881 ccatgcatca acaggtagta caggccgtgc acggcgtcga tatggcccag cagactccat
1841941 agctctggca atgtccggct ggctgaagcc gagatcgttg ccccctcgtc gaaccacaac
1842001 gatggcctgc ttgcccaggc gccgctgatg accgcggcca gcactgcaat cgccagcggg
1842061 tcgagcagcc ggccgcgcat ccgcgccacc aactcgtcga cgtgtgctgc cgcgggctgc
1842121 tccagagtgg aggcggacat gatgcgggtc accttagggt ccgcgcgatg atcctggtca
1842181 ccggcggttc ggcgactggg cagcccggcg tgcggcggtg cgccgggacg actcgcatgc
1842241 atttcccaaa aagccttgca cagcaacatt ttccgcgatc agcgtgcgta ttgaatcgtc
1842301 gtgtcatcgc caccattgtc ggctggttca ccgcgatcgg gcaaatgagg gttgcgccac
1842361 gccgttgcgg tgtgattaat ctgacctatc tatatccggc aacgcgatac tgtctggggt
1842421 tggcgtagca accgacacct gggagggtaa atgagcgcct ataagaccgt ggtggtagga
1842481 accgacggtt cggactcgtc gatgcgagcg gtagatcgcg ctgcccagat cgccggcgca
1842541 gacgccaagt tgatcatcgc ctcggcatac ctacctcagc acgaggacgc tcgcgccgcc
1842601 gacattctga aggacgaaag ctacaaggtg acgggcaccg ccccgatcta cgagatcttg
1842661 cacgacgcca aggaacgagc gcacaacgcc ggtgcgaaaa acgtcgagga acggccgatc
1842721 gtcggcgccc cggtcgacgc gttggtgaac ctggccgatg aggagaaggc ggacctgctg
1842781 gtcgtcggca atgtcggtct gagcacgatc gcgggtcggc tgctcggatc ggtaccggcc
1842841 aatgtgtcac gccgggccaa ggtcgacgtg ctgatcgtgc acaccaccta gcggccgtta
1842901 ccagccgcgc gcacgccatt cgctgaggct ggggcgttcg gcacccagct ccgtgtcgtc
1842961 accgtggccg gggtagatga cggtggagtc ggcgtacacg tcgaaaaccc gggtggtgac
1843021 gtcgtcgagc agttgggtga agtcggcagg ttgccaggtt ttgccgacac cgccggggaa
1843081 caagcagtcg ccggtgaaga gctgtgtgac gcctccggtc accggcccgc cgagggccag
1843141 cgcgatcgat ccgggtgtgt gtccgcgcaa gtggatgacg tcgaatgtca gctcgccgat
1843201 gcgcacgctg tcgccgtggg tgagcaaccg gtccggtttg accggcagcg ggtcggcgtc
1843261 gatcggatgg gccgcggtcg gcgccccggt ggccgcggcc accgcttgca gcgcctgcca
1843321 gtggtcgaag tgctggtgac tggtaacgat cagggccagc ttcggcgcgt accgccggac
1843381 caggtcgatg aggacctccg cgtcattggc ggcgtcgatc agcagggttt ctccggtcgc
1843441 tgaacacgtc accaggtagg cgttgttgtc catcgggccc accgatgcct tgaggatcgt
1843501 ggcgccgggc aggaagcgac gcgccgcctt gccgcgttcg acgtgtccgg tgtagttgtc
1843561 gtcgactgtt gtcatatgcg ccactgctcc tatgccggct gcgccggcat catcgtcgtt
1843621 ggcgcgggtc atatgcgccg acgttacgac gttaccggtc ccctgatggt tgtcggtacg
1843681 ggcacatagc atgggatacg gcctttggcc ggcgagatga gtttcagtga aagggacagc
1843741 gtggctgacc gcctgatcgt caagggtgcg cgcgaacaca atctgcgcag cgtcgacctc
1843801 gacctgcccc gcgacgcgct gatcgtcttc accgggttat ccggatcggg caagtcctcg
1843861 ctcgcgttcg acaccatctt cgccgagggg cagcggcgtt acgtggagtc gctgtcggcc
1843921 tacgcccgcc aatttctcgg gcagatggac aagccggacg tcgacttcat cgaggggctg
1843981 tctccggcgg tgtccatcga ccagaagtcg accaaccgca acccacgatc gacggtcggg
1844041 accatcaccg aggtgtacga ctacctgcgg ctgttgtatg cgcgcgcggg cacgccgcac
1844101 tgcccgacct gcggggagcg agtcgcgcgc caaaccccgc aacaaatcgt cgatcaggtg
1844161 ctggccatgc cggagggcac tcggtttctg gtgctggccc cggtggtgcg tacccgcaag
1844221 ggcgagttcg ccgatctgtt cgataagctc aacgcccagg gctacagccg ggtgcgggtc
1844281 gacggtgtgg tgcatccgct gaccgatccg ccgaagctga aaaagcagga aaagcacgac
1844341 atcgaggtgg tggtggaccg tctcaccgtc aaggccgccg ccaagcggcg gctcaccgat
1844401 tcggtggaaa ccgcgctgaa tttggccgac gggatcgtgg tgctcgaatt cgtcgatcat
1844461 gaactgggtg caccgcatcg cgagcagcgg ttctccgaga agctggcctg ccccaacggg
1844521 cacgcgctgg ccgtcgacga cctggagccg cggtcgttct cgttcaactc gccctacggc
1844581 gcctgccccg aatgcagtgg tctgggcatc cgcaaggagg tcgacccgga gctggtggtg
1844641 cccgatccgg atcgcaccct ggcgcagggt gcggtggcgc cgtggtcgaa cggccacacc
1844701 gcggagtact tcacccggat gatggccggc cttggcgagg cgctcgggtt cgacgtcgac
1844761 acgccctggc gcaagctgcc ggccaaggcc cgcaaggcga ttctggaagg cgccgacgag
1844821 caggtgcacg tgcgctaccg caaccgctac ggacgcaccc ggtcgtatta cgccgatttc
1844881 gagggtgtgc tggcgttcct gcaacgcaag atgtcccaaa ccgagtccga gcagatgaag
1844941 gagcgctacg agggtttcat gcgggacgtg ccctgcccgg tgtgtgcggg cacccggctc
1845001 aagcccgaga ttctggcggt gacgctggct ggggagtcca agggggagca cggcgccaag
1845061 tccatcgccg aggtgtgtga gctgtcgatc gccgactgcg cggacttcct gaacgcgctc
1845121 acgctgggtc cgcgcgagca agcgatcgcc gggcaggtgc tcaaggagat ccggtcgcgg
1845181 ctcgggtttc tgctcgacgt cgggctggag tacctgtcgc tgtcccgggc ggcggccacg
1845241 ctgtccggcg gtgaggcaca acgtatccgg ctggccaccc agatcggctc cggcctggtg
1845301 ggtgtgctct acgtgctcga cgagccgtcc atcgggctgc accagcgcga caaccgtcgt
1845361 cttatcgaaa ccctcacccg gttacgggat ttggggaaca ctttgatcgt cgtcgagcac
1845421 gacgaggaca ccatcgagca tgcggactgg atcgtcgaca tcggcccggg ggccggtgag
1845481 cacggtggcc gcatcgtgca cagcgggccc tacgatgaac tgctacgcaa caaggattcg
1845541 atcaccggcg cctacctgtc cggccgggaa agcattgaga taccggcgat tcggcgttcc
1845601 gtcgaccccc gtcgtcaact caccgtcgtc ggcgcccgcg agcacaactt gcgcgggatc
1845661 gatgtgtctt tcccgctggg tgtgctgacc tcggtgaccg gtgtctcggg ttcgggcaag
1845721 tcgacgttgg tcaacgacat cctggccgcg gtgctggcca accgcctcaa cggcgcccgg
1845781 caggtccccg gccggcacac ccgggtcacc gggctggact atctggacaa gctggtgcgg
1845841 gtggaccaat cgccgatcgg gcgcacaccg cgatccaacc cggccaccta caccggtgtg
1845901 ttcgacaaga tccgcaccct gttcgccgcc accaccgagg ccaaggtccg cggctatcaa
1845961 cccggacgat tctcgttcaa cgtcaagggc ggtcgctgcg aggcctgcac cggcgacggc
1846021 accatcaaga tcgagatgaa cttcctgccc gacgtgtacg tgccgtgcga ggtctgccag
1846081 ggggcccggt acaaccgcga aaccctcgag gtgcactaca agggcaagac cgtctcggaa
1846141 gtgctggaca tgtccatcga ggaagcggcg gagttcttcg agccgatcgc cggcgtccat
1846201 cgctatctac gcaccctggt cgacgtgggc ctgggctacg tgcggctcgg ccagcccgcg
1846261 cccacgctgt ccggcggtga ggcccagcgg gtcaagctgg cctcggagct gcagaagcgc
1846321 tccaccgggc gcaccgtcta catcctcgac gagccgacga cgggactgca cttcgacgac
1846381 atacgcaagc tgctcaacgt gatcaacggc ctggtcgaca agggcaatac ggtgatcgtc
1846441 atcgaacata acctggacgt gatcaagaca tcggattgga tcatcgacct gggcccggag
1846501 ggcggtgccg gcggcggaac cgttgtcgcc caaggcactc cggaggacgt tgccgcggtg
1846561 ccggcgagct acaccgggaa gtttctcgct gaggtcgtcg gcggcggtgc ctcggccgcc
1846621 acatcgcggt cgaacagacg gcgcaacgtc agcgcctgag ctggactatc gccgcgcgtc
1846681 aagtctgtgc tcacggcggc gaactgggtg cggtctcact catcggtgtg catcgactca
1846741 cggatctgag ctagccgttc ggctgccgcg cgctgccgct gcgcgtactg atcttcgagc
1846801 cggcggcctt gcgggctctc ggcgtcgagt tcggttgccc ccagggccgt tccgtatcgg
1846861 gtttcgatct tctcgcggac ggattcgaag gtcggtaccc cagcgctgtc gtaccgcgga
1846921 tcggactcgg aattcggcgt cgtggcttcc ggtggtgtcg gttcgtcggg catgctctgg
1846981 caatgctcct atctgccggt accggcgatc tgctgtgtcg tacccggcaa cgggatctta
1847041 ggcactcccg gagtggccag ttggccggcc agccatggca gcgccgcagc gaaaacccgg
1847101 tcggcgaaag gccagtcgtg cttgcccggt tgtggaacca cggcgcagta gatgccgttg
1847161 gcgcggccga gggcgcacag tgcattggcg gcagcggcct ggttgcctgg gttggcggcg
1847221 gcatcgcgac cggccagccg catcgtggtg gtatcggcga cagcgttgtc gggcgagggt
1847281 ggacccggcg aagagatcgc gaaccaaccc gacagtccgg tgtagctgcc atgccgggtg
1847341 atcaccgtcg tcgggtcaaa cgccgaccag gcgtcttcgt tgccgccgaa caacctgacg
1847401 atggtttgcg tcttgttgcc agcgttcggg tagaaatcac cggcgatgtc gacaaacgcg
1847461 ctaaacagtg tcgggtgcat gacggtcaga tccaccgcgc aggtcccacc catcgaccaa
1847521 cccacgatgc cccagctggt ctgttcggga ctgacgccga atttcgagac catgtagggc
1847581 acaacatctt tagtcaagtg gtcggccgcg ttgccacgcc gtccattgac gcattcggtg
1847641 tcgttgttga acgcgccgcc ggaatccacg aataccacga cgggagcatt gccgctgtgg
1847701 gcggccgcaa agtcgtcgag cgtcttcacc gcgttaccgg ctcgcgccca atcggcgggt
1847761 gtgttgaatt gaccgccgat catcatcacc gtcggcagct gcggcggcgg agggttctcg
1847821 gaacgatgct ctcggtcgaa ccaggccggc ggcaggtaca ccagttcgcc gcgatgcttg
1847881 aagtgtgatg cgtcggaagg gatcaccact ggcaacaacg tgccgtgcga cggccgcacc
1847941 ccactgtgcg ccagtgcggc aacagcggcc tgatcggcct ggtcgggcaa cgggccggag
1848001 gtgagctggt tccacgcggt ctgcacggtc gggaagtagc caacccacag gttgagcgtc
1848061 aaggtcgcgc tgagcagaca gaggggcacg gccagcagcg acgcgccgcg gcgccaccac
1848121 cgcgcgctgc gccagcccag gatcaacacc gtcgccgccg cgccggtcaa cgcgacccag
1848181 atccacagcg tgctcggcgg ccgttcgttg gccaggccgt tgccggtgac ataccagcgc
1848241 gtcccccatg ccagggtggc cccgatagcg gcggccgtcg gcagccaccg ccgttgccag
1848301 tgacgtgatc gccaccctgc cgccagcacc agcacgaccg cggtcacgac ctggacagcg
1848361 agcggcaccc aaccgtgcat cagcgatgtg tggcctactg ctaacggctg cgtcgcggct
1848421 ggcggcgtcg acgcggtcac cagttcattc tgagccattt cgggcggtga tttgttgggg
1848481 gtttcctgtg atccgacgga cgcccaccgg ctccggctaa tgcggttttg ccaacggaaa
1848541 gggcagtgtt tcgcgaatgc tgcgcccagt gatcagcatg accacccggt caatgcccat
1848601 gcccaagccg ccggtgggcg gcatggcgta ctccatcgct tgcaggaagt cttcgtcgag
1848661 ttccatcgcc tcggggtctc cgccggcggc cagcagggac tgctcctgca ggcggcgccg
1848721 ttgctccacc gggtcggtca gctcgctgta ggcggtgccc agctcgatac cccacgccac
1848781 caggtcccaa cgctcggcga caccgcgctt gctgcgatgc ggtcgggtca acggtgacac
1848841 cgatgtcgga aagtcgatgt agaacgtcgg ttgctcggtg cggcactcca ccaggtgctc
1848901 gtatagctcg agcacgaccg cgccggcatc ccattgggtc cgatagggga caccggcggc
1848961 gtcgcacagc ttgcggagag tggtcaagcc ggtatcggcg tcgatgcgtt caccgagtgc
1849021 ttccgagatc gcatcatgca ccgtccgcac cggccatatc ccggagatgt cgaccggttc
1849081 gaggtggtgg cgggtgccgt cggaaccctt gtccgtccgg ggccgcatgg cgatgggcgc
1849141 cccgttggcg gcctgggcgg cgttctggat gagttcgcgg cagccgtcaa tccactcaag
1849201 gtagtcggcg tgtgcttgat aggcctccag tagggtgaac tccgggttgt ggctgaagtc
1849261 gacgccctcg ttgcgaaagg cacggccgag ctcgaatacc cgttccacgc cgccgacgca
1849321 caggcgcttg aggtagagct ctggtgcgat gcgcaggaac agatccatgg aatacgtgtt
1849381 gatgtgcgtg acgaacggtc gggcggtggc gccgccgtgc agctgctgta ggatcggcgt
1849441 ttcgacctcg acgaatccct ttgcgaacag cgtctcgcgc acagcgcgca gcacgctgct
1849501 gcgagcggtg atcagcgcac gggactcagc gttgaccgcc aggtcgaggt aacgggtccg
1849561 gactcgggct tcgggatcca gtagcccctt ccacttattc ggcaacggtc gcaaacactt
1849621 accgatcagg cgccagccgc tgacgatcaa cgatggagtt ccggtcttgc tggcgcccat
1849681 gtgtccggtc atctccacca gatcacccag atcggtcgcc gcgttgaagt cggccgcgca
1849741 gccctggtcc aggcgtgaat tatccagcag cacttgcatt tcgcccgacc agtcgcgcag
1849801 ctgggcgaac aacacaccac cgtagttacg tattcgcatg atgcgtccgg acaccgacac
1849861 gctagcctgg tggtctgcgg ccagcgcctg tgccaccgtg tgactgggcg gccggcccac
1849921 gggaaaggcg tcaatgccgc tgctccgcag cttctctagc ttgtcgaacc gaactcgcac
1849981 ctgctcgggt agccgccgct cgaccccgtc gccattggtg aggcctactt gccgcagccc
1850041 gctcacgtcc ggtgccgagc cgtcgtgatg caataggccg gtggccgcca accgctcggg
1850101 cactgccgga tgatgccccg tgtgtactcg gttgcgccgg ctgaacggca gcacgaggaa
1850161 cccctctgcg atcaccgagg cgacgcccac tcggggaatc actcgggcgt cttcgtagca
1850221 ggcgtagcgc ggtacccatt cgggttggta cttcatgttg gagcggtaga gcgtctcgag
1850281 ctgccaccac cgtgagaaga agaccagcag cccccgccac aaccgggcaa ccgggccggc
1850341 gccgagttgg gcgccctgct cgaaggccgc gcgaaacacc gcgaagttca acgaaatacg
1850401 agtgatacca aggctttcag cgtgcaaggc gagttcgctg accataagtt cgatagtgcc
1850461 gttcggggat tgtggagaac gacgcatcaa atccagggag acaccggtgg ttccccacgg
1850521 caccagcgac agcattgcca gcacctggtt gtgcggatca atcgcctcca ccagcaggca
1850581 gtcggagtcc gcggggtcgc cgaggcggcc cagcgccatc gagaagccgc gctcggtctc
1850641 ggtgtcgcgc caggaatccg cccgtgtgat ggtctgcgcc atctcgtctt cggcaatgtc
1850701 gcgatgccgc cggatgcgca ccgtcaaccc cgcccgccgg gcccgcgtca cggcctggcg
1850761 caccccgcgc atctccgggc cggacaactt gaaatcggct ggccgcagga tggcctcatc
1850821 gcccagctcg agcgcggtta ggcccgcttc gcgatatgtc tgagcccctt gtgaactggc
1850881 gcccatcacg ccgggtgccc agccgtaggt ctggcacagc cgcagccacg cgtcgacggc
1850941 ctgcggccat gctctgtggt cgcctaccgg gtcgccgctg gctaggcaga caccgacctc
1851001 gacacggtag gtgatacagg cgcggccgct ggatgcgaat accaccgact tgtcgcgacg
1851061 ggtggcgaag tagcccagtg agtcgtcctt cccatacaaa tccaataacc cgcggatagc
1851121 ggattcgtcc tctccggtca gcgcattgtc agcgcgctga gataggaaca agacgatcgc
1851181 agccccgatc aacgcgaacg cgccgaacaa cccgaagatc gcgttgagga agacgtgcgg
1851241 tctgccggtg aacagatcgg gatcggcgag ggcgaatccg accacccggt tggccgcgta
1851301 acccaaccgc tcgtccggcg ctagtgatcc cggaaacagt tcgaccagac cccaagacgc
1851361 cacgattccg accaccgcgc cggcaagcca caccgcagcc gcccgaaaca gcgcgcccct
1851421 gcggaccttg gcccagaact cccgatagcc cagcaccaga acgacgattg ccacaacatg
1851481 cacggcgaat ccgagattct ccccgaagct ctcggcggcg gtgttgccgc ccgctgcgat
1851541 ctcggcggcg ttgaccacgg cggccaggac catatttgcc agcaagacca accaggcaat
1851601 gcgtttgcgt gccgttaacg cggcggccag caatgccagc acgaaggacc acgcgaagtt
1851661 ggtgtcgggg aagttgaaca gataatcgtt gatgaattcg cgcggaacct tgatgatcca
1851721 ccgaatcaac ggcgacacac tggccagtag tgacagggtc gcgatcacgc cgacggtcca
1851781 gccggctgcc gcgggaaccc agtgataccg ggagtttccc ctggtggccg agcgaggttt
1851841 ggtgagtgtc acagaccgcg aggatattcc caaaagccgg gaaatgcccg gcgttgcagc
1851901 cctttgtagc cccgcatcgg tgtgctgagg gcaccggctg atgtcggccg ttgtcttaga
1851961 tgacgtgtca tggctgttag actggacgcc gcgaccatcc cggcgaaggc cagggacagt
1852021 taagtggagt cccactccca ccgctagcca cgagatcgtt tcacaccttc tcaaggttca
1852081 gcggtccggt cacaggcatc tcggatgcct gttctgcgtg cagcgtgggc ggctttggcc
1852141 gcgatcggtc ggcattgggc cctgcttgtg cagggctttt tttgctgatg gtttgggtgt
1852201 gttccccacc tgattccggc cgggtccaac aagctggtcg cgcctggaac agcagccaac
1852261 gagggaggcc ccatcagcac tgaaacccgc gtcaacgagc gcatccgcgt acctgaagtc
1852321 cgattgatcg gcccaggggg ggagcaggta ggcattgtgc gtatcgaaga cgcacttcgc
1852381 gtcgccgcgg acgcagatct cgaccttgtc gaagttgctc ccaatgccag accgccggtc
1852441 tgcaagatca tggactacgg caagtacaag tacgaggccg cgcagaaggc gcgcgaatcc
1852501 cgcagaaacc aacagcagac cgtcgtcaaa gaacaaaagc tgcgaccaaa gattgacgat
1852561 cacgattacg agaccaaaaa gggtcacgtc gtccgcttct tggaggcggg atcgaaggtc
1852621 aaggtcacca ttatgttccg tggacgtgag cagtcgcggc cggagttggg ctatcgattg
1852681 ctgcagcggc tgggtgcgga cgtcgccgat tacggattca tcgagacgtc cgccaagcag
1852741 gacggacgca acatgacgat ggtgctggca ccgcaccgcg gtgcgaagac ccgcgctagg
1852801 gcccgccacc cgggtgaacc ggccggcggg ccgccgccca agcccacggc cggtgacagc
1852861 aaagccgcac cgaactagct cgccagcaag acacgcagaa cctagaaatt ctagaaattg
1852921 aggaaacatg cccaaggcca agacccacag cggggcctcg aagcggttcc ggcgcaccgg
1852981 taccggcaag atcgtccggc agaaggccaa ccgtcggcac ctgctcgagc acaagccgag
1853041 cacccgcacc aggcgcctgg acggccgcac cgtggtggca gccaacgaca ccaaacgggt
1853101 cacgtcgttg ctgaacggct gaccgtaccg ccggccggct ccggcacctg accaatcacg
1853161 tccgaacgag agtaggaaga tccatggcac gcgtaaagcg ggcggtcaac gcccacaaga
1853221 agcggcgcag catcctgaag gcatcgcgag gctatcgcgg ccagcgatcg cggctttacc
1853281 gcaaagccaa agagcagcag ctgcattcac tgaactacgc ctaccgtgac cgccgggcgc
1853341 gtaagggcga gttccgcaag ttgtggatcg cacggatcaa cgcggctgcg cgcctcaacg
1853401 acatcaccta caaccggctt atccaggggc tgaaggccgc cggcgtcgag gtggaccgga
1853461 aaaacctcgc cgacattgcg atcagcgacc cggcggcgtt caccgcgctg gtcgacgtcg
1853521 cccgggcggc actgcccgaa gacgtcaacg ccccctccgg ggaggccgcc tgatccggat
1853581 tccggcctga ggcagggcta cgccggtgct caccgaacgc tcggccaggg tggccacggc
1853641 ggtcaaactg catcgtcacg taggccggcg ccgggcggga cgttttctcg ccgaaggccc
1853701 caacctggta gcggcggcgt tggcgcgcgg gctggtacgg gaggtattcg tcaccgaagt
1853761 tgcggcgcgg cggcacgagc tcttgttggc cgcgcacgag gcttcggttc atctggtgac
1853821 tgagcgggcc gcgaaggcgc tctctgatac ggtcacgccg gccgggttgg tggcggtgtg
1853881 cgatctgccg gcgacccgac ttgaggatgt attggccggc tcacctcagc tgatcgcggt
1853941 gaccgtcgag atccgcgagc cgggcaacgc gggcacggta atccgcatcg ccgacgccat
1854001 gggtgccgcg gcggtgatcc tcgccgggcg cagcgtcgac ccatacaacg gcaagtgtct
1854061 gcgcgcgtcc accggtagca tcttcgcgat cccggtcgtc gtcgcgcccg atgtcggtgc
1854121 cgccatcgcc gacctgcgag cggccggact gcaggtgctg gccaccgcag tggacggcga
1854181 gatggctctc gacgatgccg atcggctgct tgccgagccg acggcatggc tgttcgggcc
1854241 cgaagcacac gggttgtcgg ccgagatcgc ggccttggcg gaccaccgcg tacacatcct
1854301 gatgtcggga ggggcggaga gcctcaacgt cgcggccgcg gccgcgatct gtctgtatga
1854361 gagcgctcgg gcgttgggcc gccgctgatt gtccggccct acgcagcgcg gctggggccc
1854421 cgcgccggcc gcacgccggc cagcgaaagt gtggaatgga ccagcgcccc ggcgcgttcc
1854481 atcagggcct tggcgggatc gagagccgac cgggtaaagc gatgggaacg gggtgggaag
1854541 tagtgcatcg gcagcccctg ccgatcccgt ggtggcgcca tgaagccggg cgcttgcacc
1854601 aggggcgcgt catggcgagt acggcctgcc gctcgccggt aggcggccag cgcgcgcggg
1854661 tgcaaccgga tttcgtcggg caccgccaaa aacgccagtt ctaccacctt gccgaacact
1854721 cgcagcaaca cctcgtcacc cggtgtccag tgcattcccg ccttctcccg cacggccggg
1854781 tcgaacaggc cggccgcgat ccagcgctga ccggctatta gcggcttgaa cagctgatcc
1854841 cagatcggcg ttggcatgag tacaaacctc ggtttgggaa tccgcatctg gaggatgtcc
1854901 acggtcgcct gattgatctc gagcttgtcg cggcacaccc ggtcccaata gtcctgaaag
1854961 tcttcccacg acttgggcac cggtcgcatg ctcatcccat acatccggta ccagcgcacg
1855021 tgctcctcga agagctggtg tttttcggcc tcggtcaagc ctccgcagaa gtattcggcg
1855081 accttgatga caagcatgaa aaacgtcgca tgcgcccagt agaacgtatc tggattcagc
1855141 gcgtgatagc gacgcccctc agcgtcgact cccttgatgg ttcggtggta gcccttgatc
1855201 tgctggccgg tctgggccgc tcggtcaccg tcatagacca cacccatgat cgggtacacc
1855261 gagcgggcta cccgctgcaa gggttcgcgg agcaggattg aatgctcctc gacaccggca
1855321 cctagctcgg gatacatatt ttggatcgcg ccgatccaca cacccatcat cccggtgcgc
1855381 aggtctccga aatatttcca ggtcagcgaa tcgggcccga gcgggtcggc ggatgtcctc
1855441 gatgcgacag tcatgactgc ctccgtgcca ggttagtctg cgcccacgat aggcattgac
1855501 aacgcgcgtt gtccacgatt tggtccgccg atatcgcgcc gtgtcaccca gtgcctcctc
1855561 cgggtggcaa cgagcgtgga cgaggactgc agctgcatag cttggcccgc ggtgcgtgcg
1855621 ggggcaggga gtccaatgaa aaatgttgct tagaacgcca gaaagttttt aactagatca
1855681 ggattgctta gctgtagact ttatttctca atgaccacgt aaggattgct gcggccagta
1855741 caacgtgtac aaggagtcgg gctatgtcgt ttctcaccgt ggcgccggac atggtaacgg
1855801 cggccgccgg gaatttggaa agcgttggct cggcactgaa tgaggccgct gcggcggcgg
1855861 cgccagccac ggttgggctg gcggccccgg ccgcggatcg ggtgtcggcg gtcgtcgcgg
1855921 cgatgttggg ggcatatgcc cgggattttc aaggcatcag tgctcagatc gcgggttttc
1855981 ataaccagtt cgtgggcgcg ttgcggggcg gtgcggccgc ctacgccagc gccgaagccg
1856041 ccaacgtcca gcagaccgtg gtgaacgccg tgaatgcgcc cgcccaggcg ctgttggggc
1856101 acccgttgat cgggcccgag acggtcggct ccagcgccgc cgcggtctcc ttcggcttcg
1856161 gcccgttgct cctcgctggt agcgatccgc tgctggccgt gccattcagc tatccggcca
1856221 gtctgcccac cccattcggt ccagtaacga tgacgctcaa cgggtcgttt gatccgctta
1856281 cccaacaggt tgttttcgac tcgggatcac tcaccgcgcc cgctccgttc gtgtacggtc
1856341 ttggtgcggt aggtccagct ctcaccacca tgaccgcgct gcaaaacagc ggcacagcat
1856401 tttccggcgc ggtgcaaagc gggaacctgc taggggccgc gggcgcgctt ctgcaagctc
1856461 ccggcaacgc ggtgaccggc ttcctgtttg gccaaacagc gatatcgcag tcgataccgg
1856521 ggccatcgaa tctgggctac gagtcggtgg gtatcagcgt tccggtcggg gggctcttgg
1856581 ctccgctgca gcccgtgacg gtcacgttga cgcccacatc tggtatgccg actgccattc
1856641 aattgagtgg tacgcagttt ggcggccttc ttcccgccct actcaacggt ttctaaccgt
1856701 ctgcggacag ccgccgcaaa ccgcgtgatc agcgtgtttg atgcgacttg tgccacaaac
1856761 accgaggtcg tcattggcgg gctcagcccg caccacctac ccttgccacg tggaggtcgg
1856821 gccgcaggat tcggagtccg gcgcgcccga cgagacggca accgccatgg cgtcgccagt
1856881 acctcgacaa cggtccgcac tacgctggct gcgcaccgtg aaccgcagcc ctggcctggt
1856941 gtcattcatc caccgggcgc gccgcctgtt gcctggcgat ccggaattcg gcgacccgtt
1857001 gtccaccgcg ggtgagggtg gtccacgtgc cgcggctcga gctgccgatc ggctgctgcg
1857061 ggatcgcgat gcggcctcgc gcgaggtcgg cctgagtgtg ctgcaggtgt ggcaggcgtt
1857121 gaccgaggcc gtttcccgcc ggccggcaaa cccggaggtg acgttggtgt tcaccgacct
1857181 ggtcggcttt tccacgtggt cgttgcacgc tggtgacgat gccaccctca cgctgctgcg
1857241 gcaggtggcc cgggctgtcg aatcccccct cctggacgcc ggcgggcaca tcgtcaaacg
1857301 gctgggcgac gggatcatgg cggtgttccg caatccgacc gtcgcgctgc gagccgtgct
1857361 cgtcgcccaa gatgctgtga agtcgcttga agtgcaaggc tatacaccgc gaatgcggat
1857421 cggtatccac accggccggc cgcagcggct ggccgccgac tggctcggcg tcgacgtcaa
1857481 catcgccgcc cgggttatgg aacgtgccac caaagggggc atcatgatct cgcaaccgac
1857541 cctggacctg atcccgcaaa gtgagttgga cgcgctgggc gtcgtggccc ggcgggtgcg
1857601 taaacccgtg tttgccagca agcccaccgg cattccgccc gacttggcga tctatcgcat
1857661 caagactgtt agcgagtcga cagctgccga taacttcgat gagatgagtc ccgatgcaca
1857721 gtagaacgcg atgatctacc gcgtcgcctg cctgctggcc cggatccggt tcaccgtggg
1857781 ctacgtggcg gctcttgcat cggtcagcac caccatcctg atgcatggtc cgcaggtgca
1857841 cgcccaggtg attcggcatg ccagtacgaa cctgcacaac ctggcccatg gacacctggg
1857901 aacgctgtgg aacagcgcct tcgtcatcga cgagggcccg ctttatttct ggttaccctg
1857961 cttggcgtgt ctgctcgcgg tcgcggagct gcagctgcgc agcttgcggc tgaccgtggc
1858021 gttcgtcgtc ggtcatattg gggcgacact gttggtggcg gccgtgcttg ccggggcgat
1858081 cgagatcggc tggttgccat ggtccattag ccgggtcagc gatgtcggga tgagctacgg
1858141 tgccctcgcg gcgctcgggg cgctgaccgc ggcaatccct gggcggtggc ggccggcatg
1858201 gattggttgg tgggtatcgc tgggcttggc gactgcgacc atcggcggtg gtttcaccga
1858261 tgccggccac acggttgcgt tgctgttggg catgttagtg actgcctgct tcacccggcc
1858321 cgcgcgctgg acactcgggc ggtgtgcctt gctggcggtg gcgtcggggt tctgcttggt
1858381 gctgctagcc catagctggt ggagcttggt gagtgggtcg gccttgggtc tactcggggc
1858441 cctgggtgcc gccgggtttg cgcgttggac cagagcgcgc gccacatcgc tgccacccgg
1858501 cgcgctggcg attccgcagc cggcgctaag tcgctgagtc ccgcacaacg cgtgccgagc
1858561 cgggccgacc gaatcaccta tgatttgcac ttgcgtcacg ccgttagcgg gcaagtcggg
1858621 tacgtccatc agtccagttt ccgctccgcg acgatgcggg cggtccgaat agcctcgtca
1858681 gcaaggagag tggcgccgcg tgggtgatcc ccccctcgag tcgattgtgt cgatgttgtc
1858741 gccggaggca ttgaccacgg cggtcgacgc cgcccagcag gccatcgccc tagcggacac
1858801 cctggacgtc ctggcgcgcg tcaagacgga gcatctcggc gaccgctcgc cgttggcgct
1858861 ggcgcggcag gcgctggccg tgctgcccaa agaacagcga gccgaggccg gtaagcgcgt
1858921 caacgccgcc cgcaatgccg ctcagcgcag ctacgacgaa cggctggcga cgctgcgtgc
1858981 cgagcgcgac gcggccgtgc tggtggccga aggtatcgat gtcacattgc cctcgactcg
1859041 ggtgccggcc ggcgcccggc acccgatcat catgttggcc gaacacgtcg ccgacacgtt
1859101 catcgcgatg ggatgggaac tggccgaggg gcccgaggtg gagaccgagc agttcaactt
1859161 cgacgccctc aacttccctg ccgaccaccc tgcgcgcggc gaacaagata ccttctacat
1859221 cgcgccggag gattcgcggc agctgctgcg cacccatacc tcaccggtgc agattcgcac
1859281 cctgctagcg cgtgagctgc cggtctacat catctcgatc ggtcgtacct ttcgcaccga
1859341 cgaactcgac gccacccaca cgcccatctt ccatcaggtg gaaggcctag cggtggaccg
1859401 cggtctgtcg atggctcacc tacgtggaac gctggacgct tttgcgcgcg ccgagttcgg
1859461 gccgtctgcg cggacccgga tccggccaca cttcttcccc ttcaccgaac cgtccgccga
1859521 ggtcgatgtg tggtttgcca acaagattgg cggcgccgcc tgggtggagt ggggcgggtg
1859581 cggaatggtg catccgaacg tgttgcgggc caccggcatt gatcccgatc tctactccgg
1859641 tttcgcgttc gggatggggt tggaacgcac cctgcagttt cgcaacggca ttcctgacat
1859701 gcgcgacatg gtcgaaggcg acgtccgatt ctcgttgccg ttcggggtgg gtgcctgatg
1859761 cggctaccct acagctggct gcgcgaggtg gttgcggtcg gcgcttcggg ctgggacgtt
1859821 accccaggcg aactcgagca gacgctgttg cgcatcggcc acgaggtcga agaggtcatc
1859881 ccccttggtc cggtggacgg cccggtgacc gtggggcggg tggccgatat cgaggagctc
1859941 accggctaca agaagccgat ccgggcctgc gcggtagata tcggcgatcg gcagtatcgc
1860001 gagattattt gtggtgcaac caatttcgcg gttggtgatc tggtggtggt agcgctgccc
1860061 ggtgccacgc tgcccggtgg attcaccatt agcgcccgca aggcctacgg tcgcaactcc
1860121 gacggaatga tctgctcggc agccgaactc aatttgggcg cagaccattc cgggatcctg
1860181 gtgttgcccc ccggagccgc cgagcccgga gctgacggcg cgggcgtgct ggggctcgac
1860241 gacgtggtct tccatctggc catcacccca gaccgcggtt actgcatgtc ggtgcgcggc
1860301 ttggcccgcg agctcgcgtg cgcctacgac ctggacttcg tcgaccccgc cagcaactcg
1860361 cgggtgccgc cgctacccat cgaggggcca gcctggccgc tgacggttca gcccgagacg
1860421 ggggtgcgcc ggttcgcgct acgcccggtc atcgggatcg accccgccgc ggtatcgccc
1860481 tggtggttgc agcgccgact gctgctctgc ggtatccgcg cgacctgtcc ggcggtcgac
1860541 gtgaccaatt acgtgatgct cgaacttggc caccccatgc acgcccacga ccgcaaccgg
1860601 atcagcggaa ccctcggagt gcggttcgcc cggtccggcg agaccgccgt gaccctcgac
1860661 ggtatcgagc gcaagctcga taccgccgat gtcctgatcg tcgacgatgc tgcgacagcg
1860721 gcgatcggcg gcgtgatggg ggcggccagc accgaagtgc gggccgactc caccgatgtc
1860781 ctgttggagg ccgcgatatg ggacccggct gcggtatcgc gtacccagcg gcggctgcac
1860841 ctgcctagcg aggccgcccg tcgttacgag cggacggtgg acccggccat ctccgtggcc
1860901 gctttggacc ggtgcgcaag gctgctcgcc gacatcgccg ggggggaggt ttctcccacc
1860961 cttaccgact ggcggggtga cccgccgtgt gatgactggt caccgccgcc gatccggatg
1861021 ggagtcgatg tgccggaccg catcgccggg gtggcctatc cgcagggcac tactgccagg
1861081 cgcttggccc agatcggcgc ggtggtgacc cacgacggcg acaccttgac cgtgaccccg
1861141 ccgagttggc gacctgatct gcggcaaccc gcagaccttg tcgaggaggt gctgcggctt
1861201 gaggggctgg aagttatccc gtcggtgctg ccaccggcgc ccgcgggtcg tggactcacc
1861261 gctgggcagc agcgccgtcg cacgatcggc aggtcgctgg cgctgtcggg ctatgtcgag
1861321 attctgccga ctccatttct gccggccggt gtgttcgatt tgtgggggct ggaagccgat
1861381 gactcacggc gcatgaccac gcgggtgctc aacccgctgg aggccgatcg tccgcaactg
1861441 gcgaccacgc tgctgccggc cctgctggaa gccttggtgc gcaacgtgtc ccgagggctg
1861501 gtcgacgtcg cgctgttcgc catcgcccag gtggtccagc cgaccgagca gacgcgcggt
1861561 gtcgggttga tcccggttga ccggcggccg accgatgatg agatcgccat gctggatgcc
1861621 tcgctgcccc ggcaacccca gcacgtcgcg gcggtgctgg ccggactgcg cgagcctcga
1861681 ggcccctggg gcccgggccg cccggtagag gcggctgatg cgttcgaggc ggtgcgaatc
1861741 atcgcgcgcg ccagccgcgt ggacgtgacc ctgcggccgg cccaatatct gccgtggcat
1861801 ccgggccggt gcgcgcaggt gttcgtcggg gaaagctcgg ttggtcacgc cgggcagctg
1861861 catcccgccg tgatcgagcg ctcgggtctg ccgaaaggca cctgcgcggt ggaactgaac
1861921 ctagatgcga ttccgtgcag cgcgccgctg ccggcaccca gggtgtcgcc gtatccggcc
1861981 gtgttccaag acgtcagcct ggtggtggcc gcggacatcc ccgctcaggc ggtggccgac
1862041 gccgtgcgcg cgggggcagg cgacctgctg gaggatattg cgttgtttga cgtgttcacc
1862101 ggcccgcaga ttggtgagca ccgcaagtcg ctgaccttcg cgctgcggtt tcgtgcgccg
1862161 gatcgcacct taaccgaaga cgacgccagc gccgcccgcg atgccgctgt gcaaagcgca
1862221 gccgaacggg tgggtgccgt gctgcgtggc tgaaccgact cagcacgcgt tcaacgaaaa
1862281 tttgacgacg gcatttcagc gcgccgcgtt tatacctcgc cgccctgtcc gggtagcggc
1862341 gccgccctaa ggggcaattg cctgcgctag ctgtgtggga gcgtagttca ccaacgcggg
1862401 aacgatgccg ccggcgggcg taccttcgag cgtaacggta accggcccga tgaccggtat
1862461 taccgccgtg gcctgaaacg gctgcagagg cgcaagaatg ccgccgacgg gaacctcgac
1862521 cgtcaccgga atcccccctg tcgccgatgt tggcagggcc agcggcagcc tggcctcgcc
1862581 attgaggaag ccgttggcga cgttggcggg agcaccgacc agggccgccg ctgccgcctg
1862641 caggtttccg gcctgcacgg cgctgacgaa cgctgtcgtg ctctcggcga atgcgattgc
1862701 cgtcgtgatc ggcgaaccca ccgcattaag ggtcatcgcc agcggcaatc caaacgtcat
1862761 caccccggtc aagttcgtgg tatcgatcga aaaggcgatg gttgtgtccg tgaccgtcat
1862821 caccacattg gtgaagtttt gtgacatggc gccggggatg ctcaggatgg ggaacaggtc
1862881 tcccaccggc ccgagcagca ggatgttcga caagtcactc gcgtcaacac cgctgacgaa
1862941 gaccttcacc accgccccta acacgtcggt caccgcgccg ctgacgtcgc ctgccgcgag
1863001 ggcttgcaag gccgattgca ggctcggcgg tatgccagcc agcccaatag cgaagtccct
1863061 ggtggcatct gtcagcgcgg ttagggtcag ctggccgtag ccgaactggt tggcgaggta
1863121 ctgctgcagg aacggcgccg ggtcggcaag ccaggtattg ccgatgctcg ccaggttggc
1863181 gaccgtgttg gcgatgaggt cttcgtatgg cccgaggatg ggaacactgc tgctcaggct
1863241 agggaaggcc agcgctgccg cgcccggtgg accggagctg ccactttggc cgaacaacac
1863301 cccgccggtg ccaccggtgc cgccattacc cggggcaccg gccgggctgc cggcgccgcc
1863361 ggcgccaccg gcgccaccgt caccaccgtt gccgatcaag gtggcgttgc cgccgtgacc
1863421 gccgtcgcta ccggtgccgc cggccttggt accggaaccg gcgccgcccg cgccgccggt
1863481 tccgccggtc ccgccgtcgc cgaacacttg gccggcgttg ccgccgtttc cgctggcacc
1863541 gcccttaccg ccgataccgt tgccgccact gtgatcccca ccggtaccac cggcgccgcc
1863601 ctgcccgcca ttaccgaacg cgatggcgct gcctccggtg ccgccgatac cgccggtgcc
1863661 accctcaagg gcgccatcgg cggtggtgcc accgttgccg ccgttcccac cggccccacc
1863721 gttgccccat atcagcccgc cggcaccgcc gtgaccgccg gcaccgccgg taccgccggg
1863781 acttgcgaag agggagccag agttagcccc accagtgccg ccgttcccac cggccccacc
1863841 gctgccgaga agcaacgcgg tgccgccgct gccgccggca ccgccgacac cggagctaaa
1863901 tagcgctgca gccccaccgg cgccaccggc cccaccgttg ccgccattgc cgatgaagct
1863961 actgcccgcg gcaccaccgg cgccgccggc accggcgttg gcgagtatgt tgatagcagc
1864021 cccgccgatg ccaccggccc ccccgttccc gccgttgccg tagagcagcc cgccgacgcc
1864081 gccggccccg ccggccccgc cggctccgct ggtagcgctg gccagatcgc tgctcgtccc
1864141 ccccttgccg ccgacgccac cggtcccacc gttaccgaac aagctggcgt tgccgccagc
1864201 acccccggca ccgccgacgc cggagtcgaa caatggcacc gtcgtatccc caccattgcc
1864261 gccggcccca ccggcaccgc cgttgccgta cagcaggccg gcgttgccgc cggccccgcc
1864321 agcgccggcg ttcatgccga cgcccaacaa tgacgtggcg gcgccgccgt cgccgccggc
1864381 accgccggag ccccacaggc cgacgctgcc gccggccccg ccggccacgc cgctaccggt
1864441 gagaccgctg gtgccgccag cgccgccggc accgccattg ccgaccaggg tattcccgcc
1864501 cgcacccccg gcggcgacgg tgctcgatcc gccgtccccg ccgttgccga acagtgcatt
1864561 tccacctgca ccgccagcct tcgaggtgct ggaaccaccg tccccgccat tgccgaacaa
1864621 cccgccgtcc gcgccggcta gccccgatcc ggccccagca ttgccgccgt taccaaatat
1864681 cgtcccggcg tggccggcgg ctccgccgga agccccactt ccgccgttcc cgccgttgcc
1864741 gaacagcagg gcgttgccgc cggccccacc ggccgcagcg gcactgcccc cgttgccgcc
1864801 ggcaccgccg ttgccataca acagtccgcc ggtgccgccg gccccgccag cgccgcctgc
1864861 acctccagca ccgccggcgc cgccggcgcc gccgttgccg atcaatccgg cggccccgcc
1864921 gttaccgccg gccccgccgt tgccgccgtt gccgtacaaa attccaccgg gcccgccgtt
1864981 gccgccggca tttgacccgg tccccgccac tccatcggcg ccgttgccga tcagtgggcg
1865041 ccccagcagc gtctgcgtgg gcgcattcac cgcgtcgagc agggcctgca tcgacgacac
1865101 gctggcggcc tcggcgccgg tataggccgc cgcgccgccg ttcaacaagc tcacgaactc
1865161 ggcgtgaaac gtcgccgccc gggcgttgag cgcttgaaat tgctgaccgt aggcgccgaa
1865221 tagtcgcgag acagccgccg acacctcatc ggcgccggcc gatgccagcg cggtcgtggg
1865281 ggtcgatgcg gcggcagcgg cttcgctcag tgccgagcga ataccagcta aattggcggc
1865341 cgctgctgtg accaagtccg gctccacgag taagaacgac atggcggtcc cccttcgact
1865401 cggcgcagct agtggacatg tgtcacggga aattcagcct agttgggtct tatgtcatgt
1865461 gagggaaaac gcacgttttc gcggacgcaa cttcgagtcc catcggcgcc gcccggcggt
1865521 gtgtcaagtc ccggcgcagt caccgcggaa tgagtttgca aactgttgca taacgatgca
1865581 aaatcggcag gtggccaatg cgacgaaggt ggcggttgcc ggtgccagcg gatatgccgg
1865641 tggtgagatt ctccgcctgc tgctcgggca tccggcgtac gccgacggcc ggctgaggat
1865701 cggtgcgctg accgcggcga ccagcgccgg cagcacgctc ggcgaacacc atccgcacct
1865761 gacgccgctg gcccatcgag tagtcgaacc caccgaagct gccgtgctcg gtggccatga
1865821 cgccgtcttc ttggccttgc cgcacgggca ttcggcggtg ttggcgcagc aactgagccc
1865881 cgagacactg atcatcgact gcggggcgga ctttcggctc accgacgccg ccgtctggga
1865941 gcggttctac gggtcgtcgc acgccggtag ctggccgtat gggttgcccg agctgccggg
1866001 cgcgcgggac caattgcgcg gcacccgccg catcgcggtg cccggctgct atccgaccgc
1866061 ggcactgctg gcgctttttc ccgcgctggc cgcagacctt atcgagcccg cggtgaccgt
1866121 ggtcgccgtg agcggtacct cgggggcggg tcgtgcggcc accaccgact tgctgggcgc
1866181 ggaggtcatc gggtcggcgc gcgcctacaa catcgccggc gtccaccggc acacccccga
1866241 gatcgctcaa gggctacgcg cggtcaccga ccgcgacgtc tcggtctcgt ttaccccggt
1866301 gctgatcccg gcctcccgtg gcatcctggc cacctgcacg gcacgcaccc gatcacccct
1866361 gtcgcagctg cgggcagcct acgaaaaggc ctaccatgca gagcctttca tttatctgat
1866421 gccggagggg cagctgccgc gcaccggcgc ggtgatcggc agcaacgcag cgcacatcgc
1866481 cgtcgcggtg gacgaggacg cgcagacgtt cgtggcgatc gccgcgatcg acaacctggt
1866541 caagggcacc gccggcgccg cggtgcaatc gatgaacctg gcgctgggct ggccggagac
1866601 cgacggcctt tcggttgtgg gggtggcgcc gtgaccgacc tggccggcac cacccggctg
1866661 ctgcgcgctc agggcgtcac cgccccggcc ggctttcggg ccgccggcgt cgccgccggg
1866721 atcaaggcct ccggtgcgct ggatctggcg ctggtgttca acgagggacc cgactacgcc
1866781 gccgccgggg tgttcacccg caaccaggtc aaggcggcgc cggtgctgtg gacccagcaa
1866841 gtgctgacca ccgggcggct gcgcgcggtg atcctcaact ccggcggcgc caatgcctgc
1866901 accgggccgg ccggcttcgc cgacacccac gccaccgcgg aggcggtggc cgcggcgttg
1866961 tcggactggg gaaccgagac cggggccatc gaggtcgccg tctgctccac cgggctgatc
1867021 ggcgaccggc tgccgatgga caagctgctc gccggcgtcg cccacgtggt gcacgagatg
1867081 catggcgggc tggtcggcgg cgatgaagcc gcccacgcca tcatgaccac cgacaacgtg
1867141 cccaaacagg ttgcgctgca ccatcacgac aactggacgg tcggcggcat ggccaaaggc
1867201 gcgggcatgc tggcgccgtc gttggccacc atgctgtgcg tgctcaccac cgacgcggcc
1867261 gccgagccgg ccgcactcga gcgggcgctg cgccgcgccg ccgcggccac gttcgaccgg
1867321 ctcgacatcg acggcagctg ctccaccaac gacaccgtgc tgctgctgtc gtccggggcc
1867381 agtgaaatcc cccctgccca ggccgatctc gacgaggccg tgctacgggt ctgcgacgat
1867441 ttgtgcgccc agctgcaggc cgacgccgaa ggcgtcacca aacgcgtcac cgtgaccgtg
1867501 accggggccg ccaccgaaga cgacgcgctg gtcgccgccc gccagatcgc ccgcgacagc
1867561 ctggtcaaga ccgcgctgtt cgggtccgac ccgaactggg gacgggtgct cgccgccgtc
1867621 gggatggcac cgatcaccct cgacccggat cgaatcagcg tgtcgttcaa cggtgccgcg
1867681 gtgtgtgtgc acggtgtcgg cgctcccggt gcgcgcgagg tggacctgtc ggacgcggac
1867741 atcgatatca ccgtcgacct cggcgtcggc gacgggcagg cgaggatccg aaccactgat
1867801 ctgtcgcatg cctacgtcga agagaactcg gcctacagct catgagccgc atcgaagcac
1867861 tgcccaccca catcaaagcg caggtgctgg ccgaggccct gccctggctc aagcagttgc
1867921 acggcaaggt cgtcgtcgtc aaatacggcg gcaacgcgat gaccgacgac acgctgcggc
1867981 gcgcgttcgc cgccgacatg gcgtttctgc gcaactgcgg catccatccc gtcgtggtgc
1868041 acggcggggg gccgcagatc accgccatgc tgcggcggct cggcatcgag ggcgacttca
1868101 agggcggatt ccgggtcacc acacccgaag tgctcgacgt ggcccggatg gtgctgttcg
1868161 gtcaggtggg ccgggaactg gtcaacctga tcaacgcgca cggaccgtat gccgtcggga
1868221 tcaccggcga ggacgcgcag ctgttcaccg ccgtgcggcg cagcgtcacc gtcgacggcg
1868281 tggccaccga catcggcctg gtcggcgacg tcgaccaggt gaacaccgcg gcaatgctgg
1868341 atctggttgc ggcgggccgg atcccggtgg tgtccacgct ggccccggat gccgacggcg
1868401 tggtgcacaa catcaacgcc gacaccgccg ccgcggcggt cgccgaagcc ctgggcgccg
1868461 aaaagctgtt gatgctcacc gatatcgacg gcctgtacac ccgctggccg gatcgcgact
1868521 cgctggtcag cgagatcgac accggcacac tggcgcaact gctgccgacg ctggaatcgg
1868581 gcatggtccc caaggtcgaa gcgtgcctgc gggcggtcat cggcggggtg cccagcgcgc
1868641 acatcatcga tgggcgggtc acacactgcg tgttggtgga gttgttcacc gacgcgggca
1868701 ccggcaccaa ggtggtgcgc ggatgaccgg cgcttcgacc acgacggcga ccatgcggca
1868761 gcggtggcaa gccgtgatga tgaacaacta cggcaccccc ccgatagcgc tggccagcgg
1868821 tgacggcgcc gtggtcaccg acgtggacgg cagaacctat atcgacctgc tcggcggcat
1868881 cgcggtcaac gtgctgggcc atcgccaccc cgcggtcatc gaggccgtca cccggcagat
1868941 gtcgacgctg gggcacacct ccaacctgta tgccaccgaa ccgggcatcg cgctggccga
1869001 ggagctggtc gcgctgctgg gggccgacca gcggacgcga gtgttcttct gcaactccgg
1869061 cgccgaggcc aacgaggcgg cgttcaagct gtctcggctc accggacgca cgaaactggt
1869121 cgccgcccac gacgccttcc acggccgcac catgggctcg ctggcgctca ccggacaacc
1869181 ggccaagcaa acgccgttcg cgccgctgcc cggcgacgtc acgcacgtcg gctacggcga
1869241 cgtcgacgcg ttggccgccg ccgtcgatga ccacaccgcc gcggtgttcc tggaaccgat
1869301 catgggggag agcggggtcg tcgtcccgcc cgcgggctac cttgccgccg cccgcgacat
1869361 cacggcgcgg cgcggcgcgc tgctggtgct cgacgaggtg caaaccggga tgggccgcac
1869421 cggagcgttc ttcgcccacc agcacgacgg catcaccccg gacgtggtga ccctggccaa
1869481 gggtctgggc ggcgggctgc cgatcggtgc ctgcctggcc gtcgggccgg ccgccgaact
1869541 actgacccca ggcctgcacg gcagcacctt cggcggcaac ccggtctgcg ccgcggcggc
1869601 gctggcggtg ctacgggtgc tggcgagcga cggcctggtc cgccgcgccg aagtcttggg
1869661 caaatcgttg cggcacggca tcgaagcgct cggccacccg ctcatcgacc acgtgcgcgg
1869721 acgcggactg ctgttgggca tcgcgctgac cgccccgcac gccaaggacg ccgaggccac
1869781 cgcccgcgac gccggttacc tggtcaacgc ggccgcaccc gacgtcatcc ggttggcgcc
1869841 gccgctgatc atcgccgaag cacagctcga cggctttgtc gccgccttgc cggcaatcct
1869901 ggaccgcgcc gtgggggccc cgtgatcagg catttcctgc gcgacgacga tctgtccccg
1869961 gccgaacagg ccgaggtgct cgagctcgcg gccgagctga agaaagaccc ggttagccgt
1870021 cgtcccctgc aagggccgcg cggggtggcg gtcatcttcg acaagaactc cacccgcacc
1870081 cggttctcct tcgagctggg catcgcgcag ctgggcgggc atgccgtcgt cgtcgacagc
1870141 ggcagcaccc agctgggccg cgacgaaacc ctgcaggaca ccgcaaaggt gttgtcccgc
1870201 tacgtcgatg ccatcgtctg gcgaaccttc ggccaagagc ggctggacgc catggcgtcg
1870261 gtcgcgacgg tgcccgtgat caacgcgctc tccgatgagt tccatccgtg tcaggtgttg
1870321 gccgacctgc agaccatcgc cgaacgcaag ggggcgctgc gcggcctgag gttgtcctac
1870381 ttcggcgacg gcgccaacaa catggcccac tcgctgctgc tcggcggggt caccgcgggt
1870441 atccacgtca ccgtcgcggc tcccgagggc ttcctgcccg acccgtcggt gcgggccgcg
1870501 gccgagcgcc gcgcccagga taccggcgcc tcggtgactg tgaccgccga cgcccacgcg
1870561 gccgccgccg gcgccgacgt tctggtcacc gacacctgga cgtcgatggg ccaggaaaac
1870621 gacgggttgg accgagtgaa gccgtttcgg ccgtttcagc tcaactcgcg acttctggcg
1870681 ctggccgact cggatgccat cgtgttgcat tgcctgccgg cccatcgcgg cgacgagatc
1870741 accgacgcgg tgatggacgg gccggccagc gcggtgtggg acgaggccga aaaccggctg
1870801 cacgcgcaga aggcgctgct ggtgtggctg ctggagcgct catgagccgc gccaaggccg
1870861 cgcccgttgc ggggcccgag gtcgccgcaa accgcgccgg ccgccaggcg cgcatcgtgg
1870921 cgatcctgtc gtcggcgcag gtgcgcagcc aaaacgaact ggcggcgctg ctggccgccg
1870981 agggcatcga ggtcacccaa gccacactgt cacgcgatct ggaagagctc ggcgcggtga
1871041 aactgcgcgg cgcggacggc ggcaccggca tctacgtggt gcccgaggac ggcagcccgg
1871101 tgcgcggcgt ctcgggcggt accgaccgga tggcgcggct gctcggtgag ctgctggtgt
1871161 cgaccgacga cagcggcaac ctcgcggtgt tgcgcacccc gccgggcgcg gcgcactacc
1871221 tggccagcgc catcgaccgc gcggccctgc cccaggtcgt cggcaccatc gccggtgatg
1871281 acaccatcct ggtggtggcc cgcgagccga cgaccggcgc gcaactggcc ggcatgttcg
1871341 agaaccttcg gtaaggagag tcatgtcaga gcgcgtcatc ctggcctatt ccggcggtct
1871401 ggacacctcg gtggcgatca gctggatagg caaggagacc ggccgtgagg tggtggcggt
1871461 ggcgatcgac ctcgggcagg gcggcgagca catggacgtc atacggcagc gggcgctgga
1871521 ctgcggcgcg gtggaggctg tcgtcgtcga cgcccgcgac gagttcgccg aaggctactg
1871581 cctgcccacc gtgctgaaca acgcgctgta catggaccgc tacccgctgg tgtcggcgat
1871641 cagccggccg ctgatcgtca aacacctggt cgccgcggcg cgcgagcacg gcggcggcat
1871701 cgtcgcgcac ggctgcaccg gcaagggcaa cgaccaggtc cggttcgaag tcgggttcgc
1871761 ctcgctggca ccggatttag aggtgttggc gccggtgcgc gactacgcgt ggacgcggga
1871821 gaaggcgatc gcgttcgccg aggagaacgc gatcccgatc aacgtcacca aacgttcgcc
1871881 gttctccatc gaccagaacg tctggggccg cgcggtggag accggcttct tagagcacct
1871941 gtggaatgcc ccaaccaagg acatctacgc ctacaccgaa gaccccacga tcaactgggg
1872001 ggtccccgac gaggtgatcg tcggcttcga acgcggcgtg ccggtgtccg tcgacggcaa
1872061 gccggtgtcg atgctggcgg cgatcgagga gctcaaccgc cgcgccggag cgcaaggtgt
1872121 cgggcgcctc gacgtcgtgg aggatcggct ggtgggcatc aagagccgcg agatctacga
1872181 ggcgcccggc gcgatggtgc tgatcaccgc gcacaccgaa ctcgaacacg tcaccctgga
1872241 gcgtgagctg ggccggttca aacgccagac cgaccagcgc tgggccgaac tggtctacga
1872301 cgggctgtgg tactcgccgc tgaaggccgc gctggaggct ttcgtcgcca agacccagga
1872361 gcacgtgtcc ggcgaggtgc ggctggtgct acacggcggc cacatcgcgg tcaacggccg
1872421 gcgcagcgcg gaatcgttgt acgacttcaa cctggccacc tacgacgagg gcgacagctt
1872481 cgaccagtcc gccgcccgcg gcttcgtcta cgtgcacggg ctgtcctcca agctcgccgc
1872541 ccgccgggat ctgcggtgac ggttctcccg cgagcagacg cagaatcgca ccgccacgcc
1872601 cgtcggcgtg cgattctgcg tctgctcgcc acagaaaagt gagcaccaac gaggggtcgc
1872661 tgtggggcgg gcggttcgcc ggcggcccgt ccgacgcgct ggccgcgctg agcaagtcca
1872721 cccacttcga ctgggtgctg gccccctacg acctcaccgc gtcgcgggcg cacaccatgg
1872781 tgctgtttcg ggccgggctg ctcaccgagg agcaacgcga cgggctgctc gccggcctgg
1872841 acagcctcgc ccaagacgtc gccgacggca gcttcggccc gctggtcacc gacgaggacg
1872901 tgcatgccgc gctggagcgg ggcctgatcg accgggtcgg accggacctg ggcggccgac
1872961 tgcgggccgg gcgctcgcgc aacgaccagg tggccgcgct gtttcggatg tggctgcgcg
1873021 acgcggtgcg ccgggtcgcc accggtgtgc tcgacgtggt cggtgcgctg gcagagcagg
1873081 ccgccgcaca cccgagcgcc atcatgcccg gcaaaaccca cctgcagtcc gcccagccga
1873141 tcctgctggc acaccatctg ctcgcgcacg cccaccccct gctgcgcgac ctggaccgca
1873201 tcgtcgactt cgacaaacgc gcggcggtgt ccccgtacgg ctcgggcgcc ttggccggct
1873261 cgtcgctggg cctggatccc gacgcgatcg ccgcggacct cggtttctcg gctgccgcgg
1873321 acaactccgt cgacgcgacc gccgcccgcg acttcgccgc cgaggcggcg ttcgtgttcg
1873381 ccatgatcgc cgtcgacctg tcccggctgg ctgaggacat catcgtctgg agctcgacgg
1873441 aattcggcta cgtcacgttg catgactcgt ggtccaccgg tagctcgatc atgccgcaga
1873501 agaagaatcc ggacatcgcc gagctggccc gcggcaagtc cgggcggctg atcggaaacc
1873561 tggccgggct gctggccacc ctgaaagccc agcccctggc ctacaaccgc gacctgcagg
1873621 aagacaagga gccggtgttc gattcggtgg cccagctgga gctgctgctg ccggcgatgg
1873681 ccgggctggt ggccagcctg accttcaatg tccagcggat ggcggagctg gccccggccg
1873741 gctatacgtt ggccaccgat ctcgccgaat ggcttgtgcg gcaaggtgtt ccgtttaggt
1873801 ccgcgcatga ggccgcgggt gcggcggtgc gtgcggccga acagcgcggc gtggggctgc
1873861 aggaactcac cgacgacgag ctggccgcca tcagccccga gctgaccccg caagtccgcg
1873921 aggtgctgac catcgaaggc tcggtgtcgg cccgcgattg ccggggtggc accgcgccgg
1873981 gccgggttgc cgagcaactg aacgccattg gtgaagccgc cgagcggctg cgccgccagc
1874041 tggtgcgctg agggggcctc gaaactttgc cggccagttc caggcgggct aaacttcggg
1874101 ctctaggcga cccggttgaa ccattcggcc tcgatgtgcg tgtcaaaggg gtgggaccag
1874161 tgagcgtcat cgcaggtgtg ttcggcgcgt tgccgccgta tcgctattca caacgcgagc
1874221 tcaccgactc gtttgtcagc atcccggatt tcgagggcta cgaagacatc gttcgccagc
1874281 tgcacgccag cgccaaagtc aacagccgcc acctggtctt gccgctggag aaatacccga
1874341 agctgaccga cttcggcgag gcgaacaaga ttttcatcga aaaagccgtg gacttgggcg
1874401 tgcaagccct ggcgggggca ctcgacgagt ccggtctgcg acccgaggat ctcgacgtgt
1874461 tgatcaccgc cacggtcacc ggactggcgg tgccgtcgct ggatgcccgg atcgccgggc
1874521 ggctggggct gcgcgccgat gtccggaggg tgccgctgtt cgggctgggc tgcgtggccg
1874581 gggcggccgg ggtcgcccgg ctgcacgact acctgcgcgg ggccccggac ggcgttgccg
1874641 cgttggtctc ggtcgagctg tgttcactca cgtatccggg atacaagccg acgctgccgg
1874701 gccttgtcgg cagtgcgttg tttgctgacg gcgccgcggc ggtggtggcc gcaggtgtga
1874761 agcgcgccca ggacatcggc gccgacgggc cggacatcct ggattcgcgc agccatctgt
1874821 accccgactc gctgcgcacc atgggatacg acgtcggctc ggccgggttc gagctcgtcc
1874881 tatcacggga cttggcggcc gtggtcgagc agtatctggg caatgacgtc accaccttcc
1874941 tggcttcgca cggcctgagc accaccgacg tcggcgcctg ggtcacccat cccgggggac
1875001 ccaagatcat caacgccatc accgagaccc tcgacctgtc gccgcaggct ctcgagctga
1875061 cgtggcgctc gttgggcgaa atcgggaatc tgtcgtcagc gtcggtgctg catgtgctgc
1875121 gtgacaccat cgccaaaccg ccccccagcg gaagtcccgg gttgatgatc gccatgggcc
1875181 caggcttctg ttccgaactc gtgttgctgc gctggcactg atgctggatt ccgcgagcgt
1875241 aacgccactg cgctattcgg atcgcaatct cgcagtgacg ttacgctcgg cggacctcgt
1875301 gccatgaaca gcactcccga agacctcgtc aaggccctgc gcagatcgct caagcaaaac
1875361 gagcgactga agcgagagaa ccgggatctt cttgcccgga ccaccgagcc ggtggcggtg
1875421 gtggggatgg gatgccgcta tccgggtggg gtggattcgc cggagacgct gtgggagctg
1875481 gtggcacacg gccgtgacgc ggtttcggag ttcccggcgg atcgcggctg ggatgtggcg
1875541 gggttgtttg accccgatcc cgacgcggta ggcaagtcgt atacccggtg cggcgggttc
1875601 ttgacggatg tcgccggttt tgacgccgag tttttcggga tcgcacccag cgaggcgctt
1875661 gcgatggatc cccagcagcg gttgctgttg gaagtgtcgt gggaagcgtt ggagcgggcg
1875721 ggcatcgacc caatcacgtt gcggggttcg cagacgggcg tgttcgccgg ggtgttccac
1875781 ggctcgtatg ggggccaagg ccgggtgccg ggtgacctgg agcgctacgg gctgcgtggc
1875841 tcgacgctga gcgtggcctc cgggcgggtg gcgtatgtgt tgggcctgca gggcccggcg
1875901 gtgtcggtgg ataccgcgtg ttcgtcgtcg ttggtggcac tgcatttggc ggtgcagtca
1875961 ctgcgcctcg gcgaatgcga cctggcgctg gtcggtgggg tcaccgtgat ggccaccccg
1876021 gcgatgttca tcgagttcag caggcagcgg gcgctgtccg ccgatggtcg ttgtaaggcc
1876081 tatgcgggtg ccgccgatgg gaccgcgttt gccgagggcg ccggggtgct cgtgctggcg
1876141 cggttggctg acgcgcgccg gttggggcat ccggtgctgg cgctggtgcg cggatcggcg
1876201 gtcaatcagg acggcgcctc caacgggctg gccacgccga atgggccggc gcagcaacgg
1876261 gtgatcactg cggcgctggc cagtgcgcgg ttaggtgtcg ccgacgtgga tgtggtcgag
1876321 gggcacggga cgggcaccac gttgggggat cccattgagg cgcaggcgat tttggcgacg
1876381 tatggacagc ggccggccga tcggccgttg tggctggggt cgatcaaatc gaacatcggt
1876441 catacgtcgg cggctgcggg ggtcgccggg gtgatcaaga tggtgcaggc gatgcgccac
1876501 ggcgtgctgc ccaagacgtt gcacgtggat gtgccgacgc cgcatgtgga ttggtcggcg
1876561 ggggcggtgt cgttgttgac cgagccgcgg ccgtggcacg tgccgggccg gccgcggcgg
1876621 gccggtgtgt cgtcgttcgg gatcagcggc accaacgcac atgtgattct ggaagaggca
1876681 ccggcagtgg aaccggttgg cgcggcccat ggcaacgacc cggtggcggt gccgtgggtg
1876741 ctgtcggcga ggtcggcgca agcgttgacc aaccaggcgc gacggctgtt ggcctgggtg
1876801 ggcgccgatg agaacgtgcg cccgctcgat gtggggtggt cgctggtcaa cacccggtcg
1876861 ctgtttgatc atcgggccgt ggtcgtgggc gccgaccgca ctcagctgat ggaagggctg
1876921 acgggtctgg cggccggcgt gcccggcgcc gacgtggtgg cgggccgcgc ccagacggtg
1876981 ggcaagacgg cattcgtgtt cccgggccag ggcgcgcagt ggctgggcat gggagcccag
1877041 ttatgtgcta ccgcaccggt gttcgccgaa catatccatc gctgcgaacg ggcgctgcgt
1877101 gagcacgtgg agtggtcgct gctcgacgtg ctgcgcgggg cacccggcgc accggggctg
1877161 gatcgggtgg atgtggtgca gccggcgttg tgggcggtga tggtgtcgct ggccgaattg
1877221 tggcggtcgg tgggtgtggt tcccgacgcg gtcatcgggc attcgcaggg ggagatcgcg
1877281 gcggcatatg tggcgggcgc cctgtcgctt cgggacgcgg ctgcggtggt ggcactgcgc
1877341 agccggttgc tggtgcggtt gggcggtgcc ggcggcatgg tctcgttggc ctgtggccag
1877401 ccgcaggccg agaagttggc gtcccaatgg ggagaccgac tgaatatcgc tgcagtcaat
1877461 ggtgtctcgt cggtcgtgct ggccggcgag acggatgccg tgacggagct gatgcagcga
1877521 tgtgaggccg aaggcattcg tgcccgcagg atcgacgtcg actacgcgtc acactcggcg
1877581 caggtggacg cgatccggga ggagctcatc gcggcgctgc gaggtatcga accccgtact
1877641 tccacggtgg cgttcttctc cactgtcacc ggcgaactca tggataccgc cggtgtgaac
1877701 gccgagtact ggtaccgaag catccgccag ccggtgcagt tcgaacgcgc cgtccgcaac
1877761 gccttcgacg gcggataccg ggtgttcgtc gaatccagcc cccatccggt cctgatcgcc
1877821 ggcatcgaag agacgttggt cgactgtgat cgcggcgcta cgggtgaacc gattgtcatt
1877881 ccgacgctgg gtcgcgatga cggcggggtg ggccggtttt ggctgtcggc ggggcaggcc
1877941 cacgttgcgg gcgtgggtgt tgactggcgt gccgcgtttg ccgacctggg aggccgccgg
1878001 gtggagttgc cgacgtacgc gtttgcgcgc cagcggttct ggctagacgg cctaggtgct
1878061 gttggcggcg atctgggtgg tgtcggcttg gtgggcgccg agcatggatt gttggctgca
1878121 gtggtgcaac ggcccgactc gggtggggtg gtgttgacgg gccggatatc ggtggtcgct
1878181 gcgccgtggc tggccgatca tgcggtgggc ccggtggtgc tgttcccggg cacggggttt
1878241 gttgagttgg ccttgcgggc cggtgacgag gtgggttgtt cggtgctgca ggagttgacg
1878301 ttgcaggcac cgttggtgct gccggcagat ggggtgcggg tccaggtggt ggtgggcggc
1878361 gtcgagcagt cgggtactcg gaatgtgtgg gtgtattcgg ctgccggcca ggcggattcg
1878421 agtccgggat ggacgttgca cgcgcagggc gtgttggggg ttggctcggt gcagccggcc
1878481 gcggagctgt cggtgtggcc gccggttggg gcacgggcga tggacgtcgc cgacgggtat
1878541 caggtgttgg cggcgcgggg gtatgggtat gggccggcgt ttcggggttt gcaggccttg
1878601 tggcggcggg gggccgaggt gttcgccgac gtcactctcc ctgagggtgt gccgatacgg
1878661 gggtttggga ttcatccggc ggtgttggat gcggcgttgc atgcgtgggg aattgtcgag
1878721 ggtgagcagc agacgatgtt gccgttctcg tggcaggggg tgtgtttgca cgcaagcggg
1878781 gctgcgcggg tccgtgtgcg actggcgccg gtgggccggg gggcggtgtc ggtggagttg
1878841 gccgatccgc aggggttgcc ggtgttgtcg gtgcggcagt tgatggttcg tccggtctca
1878901 gcggccgcgt tgtcgaggtc gaccgccggc gaccggggat tgctggagat gatctggaca
1878961 ccggtgccgt tggagggcgg cgacattggc gacgacgccg tggtgtggga gctgccgcct
1879021 cacgccggcg cgcaggccgg cggggatgtg ctggcagcgg tgtaccgggg tgtgcacgag
1879081 gtgttggagg tgttgcagtc gtggttggct agcgatgcga ccggtctggg tgtggtggtg
1879141 acgcgtgggg cggtgggtcc ggttgatgac gatgtcaccg atttggcggg tgctgcggtg
1879201 tgggggttgg tgcgctctgc ccaggctgaa catccgggcc gggtggtgtt ggtggatacc
1879261 gatgggtcgg tcgctgtcga ggatgcggtt ggtttcggcg cacgctcggg tgagccgcag
1879321 ctggtggttc gtcgaggccg ggtatatgcg gcacggttgg ccccggtagc ggccgggttg
1879381 actttgcctt cggcgtcggc tgggggctgg cggttggttg ccggtggtgg ggggactttg
1879441 gcggatgtgg tggtggcgcc cgttgctccg gtggagctgg cgacggggca ggtgcgggtg
1879501 gccgtgggtg cggtgggggt caatttccgg gatgtgttgg tggcgttggg gatgtatccc
1879561 ggcggcgggg aactgggtgt cgacggggca ggggtggtcg ttgaagtcgg cccgggggta
1879621 accggtttgg ccgttggtga ccgggtgatg gggttattgg ggctggtggg ttcggaggcg
1879681 gtggtggatg cgcggttggt aaccatggtg ccggcgggct ggtcgttggt ggaggcagcg
1879741 gccgtgccgg tggcgtttct gacggcgttt tacgggctgt cggtgttggc ggaggtcgcg
1879801 gcggggcaga aggtgttggt gcatgccggc accggcgggg ttggtatggc agcggtgtcg
1879861 ttggcgcggt attggggtgc agaggttttc gtcacggcga gtcgcgccaa gtgggataca
1879921 ttgcgggcga tgggttttga cgatatccat atctccgact cgcgatcgtt ggagttcgag
1879981 gaggcgtttc tgcgggccac cgagggcagc ggtgtggacg tagtgctgaa ctcgctcgcc
1880041 ggtgagttca ccgatgcctc gctgcggcta ctgcccagcg gtggccgctt tatcgagctg
1880101 ggtaaaaccg atattcgcga cgggcagacg gtggccgagc ggcatcgggg ggtgcggtat
1880161 cgggcgttcg atttggtcga agccggccca gaccgcattg cggcgatgct ttccgaggta
1880221 gtggggttgc tagcggccgg agtgttggcg cggttgccgg tcaagacttt tgatgcgcga
1880281 tgcgccccgg cggcctaccg gtttgtcagt caggcccgtc atatcggcaa ggtcgtgttg
1880341 accatccccg atggtccggg tgggcagtcc gggttggcgg ggggcaccgt ggtggtcact
1880401 ggggggaccg gcatggccgg ttcggcggtg gctacccatt tggtccggcg acatggggtg
1880461 gccaatctgg ttctggtcag ccgaagcggt gagcaggccg acagggcggc agaagtcgcg
1880521 gccctgttgc gcgagggcgg ggcccaggtg gcggtggtct cctgtgatgt ggctgatcgt
1880581 gatgcgctgg cggcattgtt ggcgggtctg gatccgcgct atccgcttaa aggggtgttt
1880641 catgccgctg gggtgttgga cgatgccgtg atcacgggct tgacaccgga tcgggtggat
1880701 acggtgttgc gggccaaggt cgatggggcc tggaatctgc acgagctaac cgaggacatg
1880761 gatttgtcgg cgtttgtggt gttttcgtcg atggccggga ttgtgggcac accggctcag
1880821 gggaattatg ctgcggcgaa tgcgtttttg gacgggttgg tggcctatcg gcgctcgcgt
1880881 gggctggccg gattgtcggt ggcgtgggga ctgtgggagc aggcctcggc gatgacccgg
1880941 cacctcggcg agcgggatcg cgccaggatg acgcaggccg ggctcgctcc gctaaccacc
1881001 gagcaggcgc tagggttcct ggacactgcg ctgcaggccg atcgcgcggt ggtagtggcg
1881061 gcccggctgg atcgtgccgc gctggccggc gctggtgctg cgctaccggc attattcagc
1881121 cagttggctg ccggtccgac ccggcggagg atcgacgccg ccgatacggc ggtgtcgatg
1881181 tcgggcttag tcagccggct gcatgcgctc acgcccgagc ggcggcagcg cgaactcacc
1881241 gatttggtga tcagcaatgc cgcggcggtg ttgggtcgtt ccagcagtgt cgatatcaac
1881301 gctcacaaag cattccaaga tctcgggttc gattccttga ccgccgtgga gctgcgcaac
1881361 cgactcaaga ccgccaccgg gctcacgttg tcgcccacgc tgatcttcga ctaccccacg
1881421 ccggccacgc tggccgaaca cctcgacagc cggctagtca ccgccagcgg tagcgatcaa
1881481 caaagcctgt cagaccgtgt tgacgacatc acccgcgagc tagttgtgct gcttgaccaa
1881541 cccgacttga gcgccaacgt caaagcgcac ctgcgcaccc gcctgcaaac catgttgacc
1881601 agcctgacca ctgaagacga cgacatcgcc gccgcgaccg aaagccagct tttcgccatc
1881661 ctcgacgagg aactcggctc ctaacccccc gcaaggaaca ccaatgtcgg gaaccaccac
1881721 gcatgttgac tacctgaagc gtctcacggc agatctgcgg cgcacccgca gacgcctgtc
1881781 cgacttggaa gccaagttgt ccgagccggt tgcggtggtc ggaatgggat gccgttatcc
1881841 aggtggggtg gattcgccgg agacgttgtg ggagctggtg gcccagggcc gtgatgcggt
1881901 atcggatttt ccggcggatc gcgggtggga tgtggacggg ttgtttgatc ctgacccgga
1881961 tgcatgcggg aagatgtata cccgccgcgg gacgtttctg gagcatgcgg gtgacttcga
1882021 cgccggattc tttggaatcg gtcctagcga ggcgctggcg atggacccgc aacagcgcct
1882081 gctattggaa gtgtcgtggg aagcgttgga gcgtacggga attgacccga ccaagttgcg
1882141 gggttcggca acgggtgtgt tcgccggtgt tatccatgcc ggctatgggg gccagctatc
1882201 cggcgagctg gaaggctatg ggttaacggg ttcgacgctg agtgtggcct ccgggcgggt
1882261 ggcgtatgtg ctggggttgg agggtccggc ggtgtcggtg gacacggcgt gctcgtcgtc
1882321 gttggtggcg ctgcatttgg cggtgcagtc gctgcggtcg ggggaatgcg atttggcgct
1882381 ggccggtggg gtgacggtga tggccacccc cgccgcattc gtcgagttca gccggcagcg
1882441 ggcgctggcg cgcgacggtc ggtgcaaggt atacgccggt gccgccgacg ggaccgcgtg
1882501 gtcagaaggc gccggggtgc tggtggtgga gcggctggtg gatgcacggc ggttggggca
1882561 tccggtgctg gccctggtgc gcggatcggc ggtcaatcag gacggcgcct ccaacggttt
1882621 gacggcaccc aatgggccat cccagcagcg ggtgattcgg gcggcgttgg ccagtgcgcg
1882681 actgcgcgcg gttgaggtgg atgtggtcga ggggcacggg accgggacca tgctggggga
1882741 tccgattgag gcgcaggcgc ttttggcgac ctacggtcag gaccgcgttg agcccctgtg
1882801 gttggggtcg atcaaatcga acatcggtca tacatcggcg gcggcggggg tggccggggt
1882861 gatcaagatg gtgcaggcga tgcggcatgg ggtgatgccc aagacattgc atgtggatgt
1882921 tcctacgccg catgtggatt ggtcggtggg ggcggtgtcg ttgttgactc aaccgcgggc
1882981 gtggtcggtt cacggccggc cgcggcgggc cggggtgtcg tcgttcggga tcagcggcac
1883041 caatgcgcat gtgattcttg agcaggcacc ggtagttgaa agtgttgtgc cagaagttgc
1883101 atccccaaca gcggcgtccg ccgtgccgtg ggtgctgtcg gcccggtcgg agcaggcgtt
1883161 ggccggtcag gcgcagcggc tgctggcttt cgtcgcggcc aacccggatt tggatccgat
1883221 cgatgtgggg tggtcgttgg tcaagacgcg ggcgatgttc gagcatcggg cggtggtcgt
1883281 gggtgctgat cgcggggccc tgctggcggg gttggcggcg ttggccgctg gtgagtcggg
1883341 tgcgggcgtg gcagtgggtc gagcgcggtc ggtggggaag acggtgttcg tgtttcccgg
1883401 gcaaggggcc caatgggtag gcatgggagc gcagttatat gccgaattac ccctgttcgc
1883461 cctggctttt gacgcggtgg ccgaagagct ggatcggcac ctgcggctgc cgctgcgaaa
1883521 cgtgctctgg gaaggtgacg aggcgctgtt gactagcacc gagttcgccc agccggcgtt
1883581 attcgcaatc gaagtggcgt tggcaacgtt gttgcagcac tggggtatca gcccggattt
1883641 cctgatcgga cattcggtgg gcgagatcgc ggcagcacat ttggccgggg tgttgtcgtt
1883701 gaccgatgcg gcgggtttgg tggctgcccg cggcaggttg atggcggagt tgcccgccgg
1883761 tggggtgatg gtggtggtgg ccgccagcga agaagaagtg ctgccagtgc tggtcgacgg
1883821 ggcgaatctc gcggcggtca acgcgccgca ctcggtggtg gtttcagggt gcgaggcagc
1883881 ggtcagcgat attgccgatc actttgcccg caggggccgc cgggtgcatc ggctagcggt
1883941 atcacatgcg tttcattcgt tgctgatgga accgatgctt gccgagttca cgcggatcgc
1884001 tgccggtatt tcggtgtcga aaccgcggat tccgttggtg tccaatgtga ccgggcagat
1884061 ggccggcgca ggctacggcg atggacagta ctgggtggag catgcgcggc gccccgtgcg
1884121 atttgccgag ggcgtccagt tgctgaatgc ggttggggcc acaaggtttg ttgaggtggg
1884181 tcccggcggt ggcctgacag cattggtcga gcagtcgctg cctttaggcg aggcgctatc
1884241 ggtggcgatg atgcgtagag agcaccccga agtgtcgtcg gtgctcggcg ccgtggcgac
1884301 attgttcact gcgggtgccc aaatggattg gccggcggtg tttggcagtc cgggtcgacg
1884361 gatcgaattg ccgacctatg cgtttcagcg gcagcggtat tggttgccgc ctacgtcggc
1884421 gggttcggca gacatcagcg gtgttggtct gctggcagcc cggcatggtt tgttgggtgc
1884481 ggttgtggag caaccggatt cggacgtggt ggtactgacc ggccggctat cggtggggga
1884541 gcagcggtgg ttggccgatc acgtgatcgc tggagtggtg ttgctcgccg gtgcggcttt
1884601 cgtggaactg gcgctgcgag ccgccgacca ggtggattgt ggggtggtcg aggagctgac
1884661 ggtggtgact ccgttggttt tgccgacggt gggcggggtg cagctacagg tggtggtggg
1884721 tgtcggtgag atgggtcagc ggccagtgtc gatatattca cgcaacgctg agtcggattc
1884781 cgggtgggtg ttgcatgccc ggggcgtatt gggggcaaag gcggttgccc cggcagcgga
1884841 tttgtcggtg tggccgccgc tgggtgctgc cccggttgat gtcgatggcg cctatcagcg
1884901 attcgccgaa ctgggctatg aatatggccg ggcgtttcag ggtctgacgg ccatgtggcg
1884961 gcgggaatcg gagctcttcg ccgatgttgc cgtccccgac gatgtcgatg tgacgttgag
1885021 tgggttcgga attcacccac tggtgctgga tgcggccttg catgcaatgg gcatggtggg
1885081 cgagcaggca gctaccatgc tgcccttctc ctggcaaggg gtctccctgc atgccgcggg
1885141 tgcgtcccgg gttcgggcgc ggatcgcgcc ggccggtgat ggcacggtgt cggtggagtt
1885201 ggccgatcag gcggggttac cggtgttgtc ggtacaggca ttggtcatgc gttcggtgtc
1885261 gtctcagctg ttgtcggcgg ccgtcgccgc tgccgatgcc gcaggtcgcg ggttgttgga
1885321 agtggcgtgg ttgccagtgg aattggcgca caacgacatc agcgccgacc tcgtggtctg
1885381 ggagttggag tctttccagg acggtgtggg tccggtgtat tcggctacgc atcgggtgtt
1885441 ggtggcattg cagtcctggc tggcccagga gcgggccggc cgactggtgg tgctgaccca
1885501 agggtcggtc ggccaggatg ccacgaactt ggccggcgcc gcggtgtggg ggttggtgcg
1885561 gtcggctcaa gccgaacatc cgggtcgggt gatgttggtc gattcggacg gctcgatgga
1885621 tgttggagat gtcattggct gtggtgaaga gcaattgatg atccggaacg gcacagccta
1885681 tgccgcccgg ctggcacagc ttcgaccaca gccgatcctg cagttgcccg ataccaactc
1885741 gggctggcgg ttggtcgccg gcggcgcggg cgcccttgag gatttgacgt tggcatcatg
1885801 ccctgcaaag gaattggcac ctggacaggt tcgaatagag gtgcgggctt tgggtgtcaa
1885861 tttccgggat gtgttggtgg cgttgggaat atatcccggt gccgcggagt tgggggccga
1885921 aggggcaggg gtggtcaccg aagtcggtcc aggcgtgacc ggtttagcag ttggtgatcc
1885981 ggtgatgggt ctgttggggg tggcggggtc ggaagcggtg gtcgatgcgc ggctggtggt
1886041 caagctgccg aaccggtggc cgctgaccga tgctgcgggt gtgccggtgg tgtttctgac
1886101 ggcctactac gcgttacgcg tgctggcgca ggtgcagccg ggcgagtcgg tgctggtaca
1886161 cgccgctgcg ggcggggtgg gtatggcggc agtgcaactg gctcggctgt ggggattgga
1886221 ggttttcgct actgccagtc gcggcaagtg ggacacgttg cacacaatgg gatgtgacaa
1886281 cacgcatgtt gccgattcac gcacactggc attcgaggag acgttttggc tgaccaccga
1886341 gggtcgcggc gtggatgtgg tgctcaactc gctggccggt gagttcaccg acgcatcgtt
1886401 gcggttactg ccgcgaggcg gtcgcttcat cgagatgggc aaaaccgagt tcgggacgcc
1886461 caggtcgttg cccaggacca tcctggggtg gcctaccggg ctttcgactt gatggaggcc
1886521 ggaccgcagc ggattgcgca gatgctggcc gagttagtcg agttgttcaa aactgaagcg
1886581 ctgcatcggc ttccagtcaa gtcatgggat gtgcggcacg ctcgggaggc gtatcggttc
1886641 ttgagccagg cgcgccatgt cggcaaagtg gtgctgacca tgccggacgc gtgggccgcg
1886701 ggcacggtgc tgatcaccgg tggcactggg atggcaggtt ctgcggtggc gcgtcatctg
1886761 gtgagtcgat acggggtgcg gcaggtggtg ttggccagtc gtgctggtga gcacacggag
1886821 agcgtcgcag cattggtgga cgagctcggc tcggccggcg cccgagtgca ggtggtgtct
1886881 tgcgatgtgg ccgatcgtga tgcggtggcg ggtttggtgg caagccaacc agatctgact
1886941 gcagtgtttc atgcggctgg ggttcttgac gatgcggtaa tcaccggatt gacgccggag
1887001 cgggtggata aggtattgcg ggccaaggtc gatggggcct ggaatttgca tgagctcacc
1887061 cggcacctgg atgtgtcagc gtttgtgttg ttttcgtcga tggccgggat tgtgggtgcg
1887121 ccgggccagg ccaattatgc tgcagcgaac gcgtttttgg acgggttggc ggcctatcgg
1887181 cgatcacgtg gactggccgc gttgtcggtg gcgtggggat tgtgggagca ggcttcggcg
1887241 atgaccgagc atttaggcga gcgggatcgg gtccggatga gtcgggttgg actggcgccg
1887301 ttgcctacca accaggcgat gggattcctg gatgccgcgt tgctggcgga tcggcccgtg
1887361 gtggtggctg ctcggctgga tcgtgccgcg ctggccggtg ccgagctgcc ggcactattt
1887421 agccagttgg ttgccggtcc gatccgacgg atcatcgacg gcgccgatga ggtgtcgggg
1887481 tcgggattgg cgtcgcggct gcacgggctg actcccgagc agcggcaccg cgaactcacc
1887541 gagttagtat gtagcaacgc cgcgatcgtg ttggggcatt ccggcactga gatcgacgcg
1887601 cacaaggcat tccaggatct cgggtttgat tcgctgacag cggtggagct gcgcaaccgg
1887661 ctcaagactg cgaccgggtt gaccttgcca ccgaccttga tctttgacta ccccacggcc
1887721 gccgagttgg ccgaacacct cgacatccag ctggcgaacg cccctgccgt cacggtcgac
1887781 caacccaacc cgtcgactcg tttcaacgag gtcacccgcg aactacaagc attgctcgac
1887841 caacccaact ggaaccccga cgacaaaacg cgcctgatca agcgattgca agcgattttg
1887901 accgattgca ccgctccacc ggccagctcc ggcccgtcta ccacccatga cgacgaggac
1887961 atcaccaccg ccactgaaag ccagcttttt gccatcctcg acgacgaact tggaccttag
1888021 cgcacgtgca accgacaggc atcgcaatca tcgggctggc atgcaggttt cccaccgtcg
1888081 tcagccccgg cgacctctgg gacctgttgc gcgacgggcg agaggctgct ggatccattg
1888141 acaacgtcgc cgatttcgac gccgactttt tcaacctatc cccccgcgag gcgagcgcga
1888201 tggaccccag gcaacgactg gcgctcgaac tcacctggga actgctcgaa gacgctttcg
1888261 tggtgccgga aacgctgcgc ggacaaccga tcgcggtcta cctcggagcg atgaacgacg
1888321 actacgcagt actgacgctc gcggcggacc gtgttgacca tcacgcgttc gctggcacta
1888381 gtcgggcaat catcgcaaac cgcgtgtcgt ttgctttcgg gctgcgtgga ccaagcgtga
1888441 cgatcgactc cggtcagtcg tcatccctgg tagcggtgca tctggcatgc gaaagcgtgc
1888501 gaacaggcga agcgccgctg gcgattgccg gtggtgttca cctcaacttg gcacgcgaaa
1888561 cagccatgct ggaacaagaa ttcggcgcgg tatcgccgtc cggccatacc tacgcattcg
1888621 atgaacgtgc cgacggctac gtaccaggcg acggcggtgg cctcgttctg ctgaagccgg
1888681 tgcaagctgc cctggacgac ggagatcgaa tccacgcgat catccgcggc agcgcggtcg
1888741 gcaacgccgg gcacagcgct accgggctga ccgtgccgtc ggtcgccggc caggtggacg
1888801 tcatcaggcg ggcgatgtcc ggcgcggggg tggattgcca tcaggttcac tacgtcgagg
1888861 cacacgggac cggcaccaag atcggcgacc cgatcgaggc gcgggcgctg ggtgagatct
1888921 tcgcggcgcg gcaacgtcgc ccggtgagtg tggggtcggt caagaccaat attggtcata
1888981 ccgggggagc cgctggaatc gccggattac tcaaggcggt gttagcgatt gaaaatgccg
1889041 tgattccacc cagcctcaac tacgtcggtg ccgcaattga tttggatagc cttgggcttc
1889101 gggtcgacac cgcgttgacg ccgtggccgg tggcggatga gccgcgacgg gctggggtgt
1889161 cgtcgtttgg catgggtggg acgaacgcgc atgtgatcct ggaacagggt ccgacgcagt
1889221 cgccagagat agtggaatct gttgccgcag cgggtagtaa cgctccggtg gcggtgccgt
1889281 gggtgttggc tgcgcggtcg ccgcaggcgc taaccaacca ggcggggcgg ttgttggcgc
1889341 acctgactgc cgacgacggc ctgaccgcgc tcgatgtggg gtggtcgttg gtgagtaccc
1889401 ggtcggtgtt cgaccatcgc gcggtggtgg tgggcgctga tcgggggcgt ctgatggcgg
1889461 ggttggcggg gttggccgcc ggtgagccgg gcgcgggtgt ggtggtgggt cgtgcgcggt
1889521 cggtgggcaa gacggtgttt gtgtttcccg gacaggggtc gcagtggctg gggatgggcc
1889581 ggcagttgta cggccggtac tcggtgtttg cccgggcttt tgacgaggtc gttgcggtgt
1889641 tggatgggca gctgcggctg tctgtgcggc aggtgatgtg gggcgccgat gccgggctat
1889701 tggaaagcac agagtttgct cagccggcgt tgtttgtcgt ccaggtggca ttggccgcgt
1889761 tgttgcaaga ctggggtgtg ctgcccgatc ttgtgatggg tcattcggtg ggtgagattg
1889821 ctgcggcgta tgtggccggg gcgttgtcgc tggtggatgc cgcgcgggtg gtggcggcgc
1889881 gcggccggtt gatgcaggcg ttgcccgctg gtggggtcat ggtggccgta gcggccagcg
1889941 aagacgaagt ggcaccgttg ctcaccgagg gcgtgtgcat cgctgcggtg aacgcgccgg
1890001 aatcggtggt gatttcgggt gagcaggctg ccgtgggtgt ggtagtggat cgattggtgg
1890061 ggttgggtcg gcgggtgcgg cggttggcag tgtcgcatgc gtttcattcg gtgttgatgg
1890121 accccatggt cgaggagttc tcgaaggtgc tggctgatgt ctgcgtgcgg gcgccgcgga
1890181 ttgggttggt ctcgaatgtg acaggtcagc tggccggtgc tgggtatggg tcgccggcgt
1890241 attgggttga acatgtgcgc aagccggtgc ggttcttcga cggtgtggga ttggctgaat
1890301 ccctcggggc cagggtgttt gtggaagtgg gtcccggtgc cgggttggag gcgtcggtgg
1890361 cgctgctagc cagggatcgg cctgaggtgg agtcggtgct ggccggggtg gggcgactgt
1890421 tcgccgaagg ggtggcggtt gattggtctt cggtctttgc gggtttgggc ggccggcggg
1890481 tggagttgcc gacgtatgga tttgcccggc agcggttttg gttaggtgac aatggcgagt
1890541 tgtcggtgga ccagacgggc aaagacgccg gcgcaattgc gcgattgcaa agcctagccc
1890601 caccggaact gcagcgccag ctggtagagt tggtgtgctt ccatgcagca atcgttttgg
1890661 gtcgcaagag cagccatgac atcgaccccg aatgtgcttt ccaagacttg ggatttgatt
1890721 caatgagcgg ggtcgaacta cgcaatcgtc tccagatggc tatcggtttg cccggcttgt
1890781 cgctgccgcg cactttgatc ttcgactatc ccactgcgag tgccctcgcc gaatgccttg
1890841 gccagctctt aggcggccaa cacgaatcat ccgacgacga gagtatttgg cagctgctga
1890901 aaaacattcc tatccaccag cttcgacgca ccggcttgct ggacaaattg ctgctgctgg
1890961 ccggccagcc cgaggagtcc ttggctggtc ggaccgtcag cgacgaggtt atcgactcgt
1891021 taagccccga agctcttatc gggctggcgc tcgatgagga cgagaacgat attcgatgac
1891081 gaaatccgtc ctggcaggct caaattatgc tatcggcata ggtgcaaata cgacaggcgt
1891141 tgaatagcga tgtttttgcg agatcgcgta atgtggctta aactttgggc ttcgagggtg
1891201 gcaagtaact taagtgggca ggggcatgag cgtcatcgcg ggtgtgttcg gtgcgttgcc
1891261 gccgcatcgc tatagccaaa gtgagatcac tgattcgttt gtcgagtttc ccggccttaa
1891321 ggaacacgag gagatcattc ggcgtttgca tgccgccgcc aaggtcaacg gtcgacacct
1891381 ggtgctgccg ctgcagcaat acccgtcgct gaccgacttc ggcgacgcca acgagatctt
1891441 tatcgagaag gctgtcgacc ttggcgtcga ggccttgctg ggcgcgctcg atgatgccaa
1891501 cctgcgcccc agcgacatcg acatgatcgc caccgcaacc gtcaccggcg tcgcggtgcc
1891561 gtctttggat gcccggatcg ccgggcggct tggtctgcgc cccgacgtgc ggcggatgcc
1891621 gttgttcggt ctgggctgcg tggcaggggc ggcgggcgtg gcccgcctgc gcgactacct
1891681 gcgtggcgcg cccgacgacg tcgcggttct ggtctcggtt gagctttgct cgctgacgta
1891741 tcccgcggtc aaaccaaccg tgtcgagtct ggtcgggacc gcactgttcg gcgacggagc
1891801 agccgcggtg gtcgccgtcg gcgaccggcg cgccgagcag gttcgcgctg gcggaccgga
1891861 catcttggac tcgcgcagca gcctgtaccc cgactcgctg cacatcatgg gttgggatgt
1891921 cggttcccat ggcctgcggc tgcggctttc cccggacctg acgaacctga tcgaacggta
1891981 cctagccaat gacgtcacca cgtttcttga tgcccatcgg ctgaccaaag acgacatcgg
1892041 cgcctgggtg agccatcccg gtggtcccaa ggtcatcgac gccgtcgcca cgagcctcgc
1892101 gctgcctccc gaggcgctcg agctgacctg gcgctcgctg ggcgagatcg gcaacctttc
1892161 gtcggcctcg atactgcata ttttgcgcga caccatcgaa aagcggccac ccagcggaag
1892221 cgccgggctg atgctggcga tgggtcctgg tttctgcacg gaactcgtct tactgcgctg
1892281 gcgctgactt cctgatttca acggtcaatc ccggccaggg gcgcagcgcg gcaaagttgg
1892341 ccgcccgaat gcggtgagtc cgctgagcgg gcaactgcag catggccctg gcgaccagcc
1892401 gagcgagaat cacggtcatc tcggtggtgg ccatgacggc tccgatgcat cggtgcagcc
1892461 cgccgctgaa cgggatgaat tcatgtggcg cgggtttgcg gtagtccgct gcgttgggat
1892521 cccagcgcag cggacggaat tcggttggct cgggccagat ttctgggagc cggtgggtga
1892581 cgtaggcgct gaagatcaac aggcgtcccg cccggatgcg atgcccgtcg aaccagaggt
1892641 cacgcagcac cctgcgggcc gagatcacgc cgggcgagta caggcgcagc gtctcgtgaa
1892701 caactccgtt gaggtaggtg agcgcgctca ggtcatcggc ggcggggact ctgccaccca
1892761 gcacgcgcgc gacctcgctg gccgcactct cccaggtgcc gggcacggtc agcagtgcgt
1892821 agatcgccca ggccagcgcg ccgctggtgg tctcgtaccc cgcggtgatc agcgaaacga
1892881 tcgaatcgcg aatctcgttg tcgcttaacg tagtaccctc ttcagagcag ccactaatca
1892941 acgtcgtcaa catgtggtcg tcgggtctgg gtgccgtgcg cgcgtcggcg atctgagcgt
1893001 cgatgaggtc gtcgatgcgt ttgcgggctg ccatggcccg tcgccacccg ggcgagttga
1893061 cccgctgctg cagccgcatc acctgaggcg gccgtcgggt taggtccagc aggggctgca
1893121 gttgctcacc gagaaaatcg gaatgtacgg cgaggcgctg gccgaacaga ctctcggcgg
1893181 tactgcgccg gaccgccgag cgcaactctt ggtagatgtc cagccgctgt ccgggctgcc
1893241 aaccgtcgat caccgtgtcg atattggaca ccatcgttgc cacatagcgc tggacgtgat
1893301 ggtgccgcag ccccggtgcc accacactgc ggcggcgccg gtggtccgcg ccgtcgctga
1893361 cgatcagcgc ggtcggcccg tcgacgggaa ccaggctctc aaacgtttgg ctccagctga
1893421 acgcgtcggc attggcgaac acgaatctgt tggcctctgc tcccaggaga taggtgtagc
1893481 catgcccacc gactccggcg ttgatcagcg gaccgcgcca tcgatacagc gccagcagcg
1893541 cttcgccaag cgggtagcgc accgtccgat acgtcctcat tcgagcatct ccgaaagctc
1893601 cagccagcga ttctccatcg ccgcgacgtg gtcttgcagg acacgtagtt gctgggtcag
1893661 ccgggtgatg ccgacgtggt cggactggtc atgctcggcc agttcggtat gtttggcggc
1893721 cacccggtcg gccaggcggg cgagttgacg gtcgactgcg gccaactctt tttcggtggc
1893781 acgtcgctgt gcgcccgaca tcgccggcgg cgctggccgc tcggccggtg ctggggcgct
1893841 aacgcgggca gccagctgca ggtattcgtc gatgccgccg ggcaggtgcc gcaaccggtc
1893901 atcgagaatc gcgtactgct ggtcagtgac ccgctcgagc agataccggt cgtgtgagac
1893961 gacgatcaac gtacccgccc acgagtcaag caggtcttcg gtcgccgtca gcatctcggt
1894021 gtccacgtcg ttggtgggct cgtcgaggag cagcacgttc ggctcggaca acagcgtcag
1894081 catgagctgc aaccgccgac gctgaccacc ggagaggtcg tcgactcgcg cggacagctg
1894141 gtcccggcgg aacccgagac gctctagcag ctgggtcggg gtaacctcgc ggccttcgac
1894201 ctgatagccg ccacgcagcc tgcctagcac atcggcgatc cggtcgtcgg caaacggtgc
1894261 cagatcgtcc ccgtgctgat cgagcactgc cagccggacg gcttgacacg tccgacaccg
1894321 ggctggacgg tgccggcgat caagcccagc agggtcgact tgccggcgcc gttagccccg
1894381 acgatgccga tacgttcacc cgggccgatc cgccattcga tatcgcgcaa caccgggcgg
1894441 cccccagaag gctggtacga gaccgacacg ccgagcaggt cgacgacgtc ctttccgagc
1894501 cgagcggccg ccagcttggc cagctccacg gtgttgcgcg gtggcggcac gtctgcgatc
1894561 agttggttgg cggcctcgat ccggaacttg ggcttgcagg tccgcgccgg tgcgccgcgg
1894621 cgcaaccaag ccagctcctt gcgcagcagg ttctgccgct tggcttcggc cgcggcggtc
1894681 agccggtccc gctcgacgcg ctgcagcacg tacgccgcgt agccgccttc gaaaggttcg
1894741 acgattccgt cgtgcacttc ccatgttgtg gtggcgacct cgtcgaggaa ccagcggtcg
1894801 tgggtgacca cgagtaggcc gccggtattg cgggcccagc gccgccgtag gtggtcggcg
1894861 agccaggtga tgccttggat gtcgaggtgg ttggtgggct cgtcgagagc gatcacgtcc
1894921 cattcgccga ccagcaggct ggccagttgc acccgtcggc gctggccacc gctgagggtg
1894981 ctgaccgggg tgtcccaggc gatgtcggat accaggccgg cgaccacgtc ccggatacgc
1895041 gggttgcccg cccattggtg ttcgggttgg tcaccgatga gcgtccagcc gacggtgcgg
1895101 ttggggtcga gggtgtctgt ttggctgagc gcgttcaccc gcaatccgct acgccgggtg
1895161 acccgaccgg agtccggccg cagttgaccg gtgagcaggc ccagcagact ggatttgccg
1895221 tcgccgtttc gcccgacgat gccgatgcgc gccccgtcgt tgaccccgag cgtgactgcc
1895281 tcgaacacca cctgagtcgg ataggccagg tgcacggcct cggctccgag taggtgcgcc
1895341 atggggccga ccctagcgtg gcgacgatgc gggctgggat gggccgctga ggagccgcgc
1895401 ggtcgagctc tagcgtggcg acgatgcggg ctgggatggg ccgctgagga gccgcgcggt
1895461 cgagctctag cgtggcgacg atgcgggctg ggatgggccg ctgaggagcc gcgcggtcga
1895521 gctctagcgt ggcgacgatg cgggctggga tgggccgctg aggagccgcg cggtcgagct
1895581 ctagcgtggc ggcccagccg cagtgcagtt gattggcggc ggggcttgcc gggtggggtg
1895641 gaggtcgttg taggcgtcga ttgggctggg tgtgattgag gtgtttgaac atttcgtggg
1895701 tttgcacccg gttgaacggg gtcaatgtca cggcgaccgg gatactcgaa tggacgtgcc
1895761 ggggccagcc ggcaagctgc tcgtggcggc tcggcagggg cgtcgtcggt agctttctcc
1895821 agccagccca actgcggact gactgaatca gtcttgggcc accaagtcac tggaatatgc
1895881 ttgggcacaa tacatcttga tgccatgcag tggccatggt cgtcggcgta ccgattggag
1895941 ccggccgttg ctaccacatt aatcggcatc agtgcctggt gggcgaatgg cagcgtgaag
1896001 caatacgccg gtgatctgac tgatcgtgtc gccacgatga cagtttgccg gcgcacgccg
1896061 gctccgcgag tgcattatcg acagtgacac gtttggcagg acccaaggag gccgagtcca
1896121 tgattcgtgc tgtgtggaat ggaacagtgc tcgctgaggc gccgcgaacc gtacgggtgg
1896181 aaggcaacca ctactttccg cccgagtcgc tgcaccgcga gcatctaatc gaaagcccga
1896241 ccacgtcgat atgcccatgg aagggtctgg cccattacta caacgtcgtc gtggacggcc
1896301 cctatggtcc ggttaacccg gacgctgcct ggtactaccg ccggcccagt ccactggctc
1896361 gccggatcaa aaaccatgtt gcgttctggc acggtgtgac ggtcgaaggt gaatccgaga
1896421 gtcggcatgg cttggcgcgc cgggttgtgg cgtggctcgg caaatagcgg cgtgatgcca
1896481 acggtcggac ccgcggacca cgcggcgggc ctagatcggc gcgcgacgcc tgaccagctg
1896541 ccgatatggc gtatcggcat catcagtggg ctggtcggca tgctgtgctg tgtcgggccg
1896601 accatcctgg cgttggttgg gattattagt gcggcaacgg ctttcgcgtg ggcgaacgac
1896661 ctctatgaca actacgcgtg gtggttccgc gtgagcgggc tcgcggtgct tgccattctg
1896721 gtgtggtggg cgctacgaca tcgaaaccga tgtagcgtca acgcaatccg ccggttacgg
1896781 tggcggctga tggcagtgct ggcaatagcg gttggtactt acggtgtctt gtccgctgtg
1896841 acgacgtggt tcggtacgtt cgtatagttg cagtattaga cgaacggggt cgccggcgac
1896901 gggtgcagca tgatttcgga gtcgttggcg catactgtcc ggccagcgtg ccgcagtagc
1896961 aagctacaag ccgccgcggc agcaagtacg gcggcgacgg tcagcaacgc gagatggtaa
1897021 gtgccggtgg cgtctttgag gtggccggtg gcgtagggac cggcgaagct cgccagactg
1897081 gccacggcat tgaccgtcgc gatggccacg gcgacccggg gaccggccag cgcggcggtg
1897141 caacggctcc agaaagcggg catcgcggca aggattccgg cgacggcgat ggtcagccaa
1897201 ctcagcgtca ctatcggtga catcggactc aatgccgcac cgagcgcggc gctgcccgcg
1897261 gccgttgttg gcagtgtgat atggcccgct tgggcgcccg agcggtcgat gctgcggtgg
1897321 ctccaggcca acatggccag cgcggcgaca ccgtacggca gggccgccaa cgtggcagcg
1897381 gtcagcgtgg cggtgccgtg tgccagcgac gcaactagtt ggggcagaaa gaactgcaac
1897441 gcatacagcg cgaaatacag gcccccgtag acgacagcga aaaggacaag atcccaaccg
1897501 gctccactcg accgaccggt cggggcaggg gtgtcctcgg tcagccgggc cgacagctct
1897561 gcacgttcct cgggggtgag ccagcttgcc cgttgcgggt tatccggcaa caggcgccga
1897621 agaagcggcg ccagcagcag tgcaggcaat gcctcgatca caaacattgc ccgccagccg
1897681 ggtagcccgg ccatgtgaac gtggccgacg atcagcccag acagcggcag gccgaccgtg
1897741 ttggcgaccg gaatggccag cagaaaggtg gctacggcgc gggctcgctg cgcgcacgga
1897801 aaccacaccg tcagatacgc gatgacgccg gggaagaagc cgccctcggc gacgccgagg
1897861 gcgaagcgcg ccagatacaa ggtgtgcgcg ctggtgacca aggccgtggc cgccgagcac
1897921 acaccccaag ccaggacgac cgccgtgagc gttcgaccgg caccgaagcg cgccaacgcc
1897981 gcgttggcgg gaacctggaa caggacgtag ccgaggaaga agacgccggc ggcggtgccg
1898041 tatgcggtgg cgctcaggcg caggtcggcg ttcatcgcca gggctgcgac cgagatgttg
1898101 gcccgatcaa cgaagttgat cacatacaac acgaacagca ggggcaacag ccggcgcgcg
1898161 gccttgccca gggcattgtg cgtggggctt gccgcgattg tcgccacctg cggctccttc
1898221 cgtgggcctg tcgaacaatt gcatcatgaa atgaccccaa cccggtcttt gtagtccggc
1898281 gtgtcactaa cacgatcggt tatgtcattg cagtaaaacg gatttggcgt tgcgccggat
1898341 gtgtttcgcc gtcaatctcg gcgtaggggc cggcgaagaa caggctccgg cccgcccgct
1898401 gtggtggggc gagcaggatg tcgcggccga tcgaccacgc gatgtggttg gcctgcaggt
1898461 tcgcgaacag gccgtgggtg ccgtacttcg tcgcacagga ggcgtccgcc ggtagccaac
1898521 ccagcccagc gacgaagaat tccgcccagc agtggtagcc gcacacctcg caatcctgcg
1898581 caccgggctg cggtagctcc aaggcctgac cgagcacaaa tcgtgcgggg atgtcgaccg
1898641 atcggcacag cgagacgaac aatgcgtgga tgtcgttgca gttgcccacc gagcaggtca
1898701 gggcatgctc ggtgctgccc aggaaagact gcttcgtcgc gtcgtagtcc atggcgccgg
1898761 tgacgtagtc gtagatgcga cgggcctgtt cgagcgggtt ggtctcgggg ccgacgacgt
1898821 cttgggccaa cgtacgggtg cgctcatcga catcgacatg tgcttcgggg atcaaggcgc
1898881 ggctgaacaa ttgcgccgtg gccaacgggc gggcccgtgc cggatccgga gcatgcccga
1898941 tcgcccggcg ttccacaaca tagcggatag accaactcgc cgccgtcgcc aagcgcagcc
1899001 ggctgtacaa catcaggttc ccgaactccg gctcacgcgt gaggtcatag ggatcctcgc
1899061 tggtcacctc gacgtccaga acgcgttgaa acgcgccgtc accgatgacc gggcaccaca
1899121 tctcgacggt gtgggcacct tgggtggaat cgatcgtgat gtgatcggtg atttcgaaca
1899181 gcccgatcgt cgcatccgcg tgtgcggata ccgcggggtc ggtgatcgtc atcggttagc
1899241 tccttccgct gagactggtt tatgttcgaa caaccggcag atcggctgcc agccattcgg
1899301 agaacccgcc gtcgagtcgg cgggcagaaa atccgttggg gcgcaacagt tctagcgcgt
1899361 cataggcata cacgcagtaa ggtcctcggc agcaggcgac gatgtcgatg ccggacggga
1899421 gttcatcaag ccgctcggcc agttcgtcga ggggaatgct cactgccccg ggcagatgcc
1899481 cggcggcgta ttccatggcc ggccgcacgt cgaggaccag caccgacccg gcggccaccc
1899541 gagcttgcaa ctcgtctcgg ctgatcggtt ccaggctgtc tctgtcggtg tagtactgcc
1899601 gcaccaggga gccgaccgag gccagattgc gttcggccac agcgcgcacc gcgcgcacta
1899661 cgtcccacac ctgcggatcc gacagtgcgt aaatcacccg tttgccgtcc cggcggctgg
1899721 tcaccaggcc ggcgcgccga agttgcaaca agtgctggga ggcattggca aacgtcaacc
1899781 ccgacgcacg agccagcgcg tccacactgc gttcaccctg caccagcaga tccaacagct
1899841 ccaatcgatg gccgctggac agcgcttgcc cgaccagggc gaactgctcg aagatcagct
1899901 tctttgcacc ggacatgccg ccgctccatt cctcgattca gatgttcgta tattcaattg
1899961 attgtttgat catgtcattc cgacacgctg ctgcggtttc gccgccgggg cgtcgcaccg
1900021 ctactcggtg ccggctacgg cctcacccgc ggccgcgggt tcgcgaccgg gccctgcgcc
1900081 gcgccctcgg ggtgggcgga atgtcctccg cggtcagcac cggtgcattc ctgaccaccg
1900141 tgtgcctcgc gcacctggtg ctcggcgcgc ttatgggtgt actagtgcac gaattcggcg
1900201 ccgacatgct gtcgttgtgg cccgtgggac cggcgctgtg tcattgagcc cgggcgcgta
1900261 atccgtgttg gtcggtgatc tcgatgaccg catacccgac ggtgatcaat cggtcgcgct
1900321 cgaactcctt gagaatcttg ttgatcgatg ggcgctgcgc tccaagcatt gcggcgaggg
1900381 tgcgttgggc aagttcgata cgggcatcga ttgcctcgtc gagcaggagc tgcgcaacct
1900441 gcgcgggcag cgggcggcca agcatgccca ttaaccgaat ctgcgcagtc gacacccgtt
1900501 gcgccacact cgacagccac cgccgtgcga tggccgggtg ggtagctagc agccgctcga
1900561 acgcctgccg gtccaggaac aggcaggtcg cttgggtcaa ggcgcgcccc gtgtagacca
1900621 tcggcatctc cagtagcagc gggatgtcgc catcgacatc gccgggatga aggatgttca
1900681 ccacggcgcg gcgccgcctg gagccgaccg cgagctcaat taatccgtgt cgcacaatcc
1900741 acaccccgtc cgcggtttga tcggcgtgga ataccactgc cccgggggca aactccttga
1900801 cttgtaacgt ttcggccaat gccgacacat cgtcacggtg cagtggcgcc gagcctccgc
1900861 gaccgacgca ccgcgcaatc caggctgcct gtcggacctg ggcctcggaa ggcggttggc
1900921 ccccagtcac cgcatgaacg agatgccgca gcgggcgcac cgaccgatct gccatggccc
1900981 ctccttgaga gcaggcgatg ccgtcatcgt gctgccaatt gtcagcgcgc gtggattgcg
1901041 tgcgggttgg cttgccctga atgggaaatt agtcgatcga agagaacacg caagcccgtt
1901101 ctgcgcccca ggcactctgt cagcacgctg acaaaccgat tcttggcgga gttttgccat
1901161 cggtatggta ttggggtgcc tactcgattg gcccgcggtg cgaccgtgcc gactcgccgt
1901221 ctgcaggaca tcaacgatca accggtggac gtcccggctg cgaccggaag gacacacctg
1901281 cagtttcggc ggttcgcggc ctgtccgatc tgccacctgc acctgcgcag cttcgccaac
1901341 cggcaccaag aggttgcgga cagtggaatc accgaggtgg tgttttttca ttcggcggcc
1901401 gacgcgctgc gcggatacca gtccttgcta ccgttcgccg tgatcgccga ccccgaccga
1901461 gtgcagtacc gcgagttcgg cgtagagaaa agtctgggcg ccatcactca tccgcgggca
1901521 ttgtgggctg ccgttcgggg gtcggcggcg atgttgcatc gcaacgatcc ggaacgggcg
1901581 ggcgtcggat tcggtgacgg cacaacgcat ctgggattgc ccgccgactt tctcctggat
1901641 gccgatggaa ctgtcgccgc tgtgcactat gggcgtcatg ccgacgacca atggtcggtg
1901701 gatcagctca tcgacatcaa ccgctcgctt ggaggtaagg gcactcagtg actcattccc
1901761 gtctgattgg cgcacttacc gtagtcgcaa ttatcgtcac tgcatgtggt tcgcagccga
1901821 aatcccagcc cgcagtggca cctaccgggg acgcggccgc tgccacccag gtgccggcgg
1901881 gccaaaccgt tcccgcccag ctgcagttca gcgccaaaac ccttgatggg cacgactttc
1901941 acggggaaag cctgctgggt aagcccgcgg tgctgtggtt ctgggcgccc tggtgtccga
1902001 cgtgccaagg cgaagcgccg gtagtcggcc aggtcgccgc gtcacacccg gaagtgacgt
1902061 tcgtcggggt ggccggcctg gatcaagtac ccgcaatgca ggagttcgtc aacaaatacc
1902121 cggtgaaaac gtttacccag ctggctgata ccgacgggtc ggtctgggcg aatttcggtg
1902181 tcacccagca gcctgcgtac gcgttcgttg acccgcacgg caacgtcgac gtcgtcaggg
1902241 gtcggatgtc gcaggacgaa ctgacgcggc gcgtcacggc gttaaccagc cgttgatcga
1902301 cgccacgccg gtcggcttgg cgttggccca cgcagaaatg cctggccttc gcgacgagtt
1902361 ggggcttgcg ccgcgtgtga tactgccctc atgacgatgg ctcgggtgcg tcgcggcacg
1902421 gaactgttgt tgtcacctca gtcgccgccg gccaccggcg ggctgatcgt gttgaccggt
1902481 ctgcggctgt tggctgggtt gatctggctc tacaacgtgg tctggaaggt gccgccggac
1902541 ttcggtgagc gcggccggcg ggacctgtat cacttcacgc atctggcggt tgaacacccg
1902601 gtgttcacac cgttcagctg ggtgatcgag catgccgtgc tgccgtactt cacggcattc
1902661 ggttgggggg tgttgttcgc ggagtccgcg ctggcggtgc tgctgctgac cgggacggcc
1902721 gtgcggctgg ccgcgttgat cgggatcggg cagtcggtcg cgatcgggct gtcggtggcc
1902781 gagtcacccg gggagtggcc gtgggcgtac gcgatgctgc tgggcatcca cgtcgtcttg
1902841 ctgttcacct gctcgacccg gtacgccgcc gtcgacgcgg tgcgcgccgc cgccacgggg
1902901 tcggccgctc ggacggcggc gcagcggctg ctggccggtt ggggaatcgt gcttgggctg
1902961 atcggacttg tcgcggtatg gcgtggcctg ggcgatgatc gacccgccta tgtcgggata
1903021 cgggcgttgg agttctccct cggggaatac aacctgcgcg gcgcactggc gctgatcgcg
1903081 atcgcgctgg caatgttggc ggccgccaaa cgcggctggc gcaccgtcgc gttggtcgcg
1903141 gcggtggtcg cggtggccgc cgcggccgcc atctacctgc aagtcggccg gaccgcggtg
1903201 tggctcggcg ggacgaacac caccgcagcg gttttcgtgt gcgcggcggt ggtgagtctg
1903261 gcaaccgaat tccggatcgg acgggtggaa ggggcgtgat ggccacaccg ggcgttgtgc
1903321 aggaagtcgt ttccgtcgct gcagaacacg ccgagcgggt cgacaccgac tgtgctttcc
1903381 cggccgaggc ggtcgacgcc ctccgcaaga ccggcctgct gggtctggtg ctgccccgcg
1903441 agatcggcgg aatgggttcc ggaccagtgg aattcaccga ggtggtcgcc cagctgtcgg
1903501 ctgcatgtgg atcaacggcg atgatctatt tgatgcacat ggcggccgct gtcacggtag
1903561 ccgcgtcgcc tccgccgggt ctgccggatc tgttggcgga catggcttcc ggaaaacaac
1903621 ttggcacctt ggcattcagt gaaccgggtt ctcgttcgca cttctgggcg cccgtgtcca
1903681 cggcgagcgc cgacggtgac ggcatcgcgg tgcgggccga caagagctgg gtgacctcgg
1903741 cggggttcgc cgacgtctat gtggtgtccg tcggttcggc cgacggtgcc gcgggcgacg
1903801 tcgacctcta cgcggttccg gcggacacac cgggcctgcg ggtagcgggc accttcaccg
1903861 ggatgggtct gcgggggaat gcctccgcgc caatggccgt cgacattcgc atcccggatt
1903921 cgtatcgtct cggggaggcc ggcggcggat tcggcatcat gatgcaaacg gtactgccct
1903981 ggttcaatct cggaaatgcg gctgtctcac tgggtttggc gaccgcagcc accggtgccg
1904041 cggtcaagca cgtcgggacc gcccggttgg aacacctcgg tggcagcctg gccgagctgc
1904101 ccacgatccg cgcccagatc gctcggatgg gcaccacgct ggccgcgcaa aaggcgtacc
1904161 ttgaggtcgc cgccaacagt gtcagctcgc ccgacgacac caccttgacc cacgtgctgg
1904221 gtgtgaaggc ctcggtcaac gacgccgcgc tgaccatcac cgaatcggcc atgcgggtgt
1904281 gcggcggggc cgcgttctcc aagcatctgc ccatcgaacg cgccttccgc gacgcccggg
1904341 cggggtcggt gatggcgcca accgccgacg cgctctacga cttctacggc agggccgtca
1904401 ccgggctgcc gctgttctag gaggcgatat gtcaaccgaa ccgctcgtcg tgggagcagt
1904461 cgcatacaca cccaacgtgg tcccgatttg ggaaggcatc cgcggctact tccaagactc
1904521 cgaaagcccg gacacccaaa tggatttcgt gctctactcc aactacgcgc ggctggtcga
1904581 ttcgctgatc gccggccaca tcgacatcgc ctggaacacc aacctggcct acgtgcggac
1904641 cgtgctgcaa accggcgggc ggtgcacgcc attggcccag cgcgataccg acgtcgacta
1904701 caccaccgtg ttcgttgcac atgccggcag cgatctgcac ggcgctaaag acattgccgg
1904761 aaagcgcctt gcgctcgggt ccgccgactc tgcgcacgcg gccatcttgc cgctctatta
1904821 tctgcgccgg gcgggcatcg ccgagtctga cctgcaggtg atccgcttcg acaccgacat
1904881 cggcaagcac ggcgacaccg gtcgcagcga actcgacgcg gtggatgcgg tgctcgccgg
1904941 tgaggccgac gtggcggcga tcggcagctc cacgtgggcc gcgatgggcg ccgcggagct
1905001 gatgggggag tcgttgaccg aggtgtggcg caccgacggc tactgccact gcatgttcac
1905061 cgcgctggat acgctgcccg ccgaaagata ccagccgtgg ctcgaccggt tgctggcgat
1905121 gagctgggat gactccgagc atcgaaagat cctcgaactc gagggtttac gacgttgggt
1905181 gcctccgcac ctggacggct acaagccgct gttcgaggcc gtgcaggagc agggcatcga
1905241 cccgcgatgg tgatcataga gctgatgcgc cgggtggtag gtctcgcaca gggagctacc
1905301 gccgaggtcg ccgtctatgg cgaccgagat cgtgatctcg cggagcgatg gtgcgcgaac
1905361 accggaaaca ccctggtgcg cgccgacgtg gaccagaccg gcgtcggcac cctggtggtg
1905421 cgccgcggcc atccgcctga cccggcaagc gtgttgggcc ccgaccggct acccggggtc
1905481 cggttgtggc tgtacaccaa cttccactgc aacctgtgct gcgactactg ctgcgtctcg
1905541 tcgtcaccaa gcaccccgca tcgcgaactg ggggcggagc ggatcggccg aatcgtcggt
1905601 gaagcggcgc gctggggagt gcgcgaactg ttcctcaccg gcggtgagcc gttcctgctg
1905661 cccgacatcg acacgatcat cgcgacctgt gtgaagcagt tgcccaccac cgtcctcacc
1905721 aacggcatgg tgttcaaagg gcggggtcgg cgcgcgctgg aatccctacc tagagggctc
1905781 gccttgcaga tcagcctgga ctcggccacc ccggagctgc acgatgcgca ccgcggcgcg
1905841 gggacgtggg tcaaggcagt agctggtatc cggttggcgc tctcacttgg cttccgggtg
1905901 cgggtggccg cgacggttgc cagccccgca cctggcgagc tgacggcgtt tcacgacttc
1905961 ctcgacgggc ttggcatcgc acccggggat cagctggtcc ggccgatcgc gctggagggc
1906021 gccgcgtcgc aaggggtggc gctcacccgc gaatcgctgg ttcccgaggt gaccgtcacc
1906081 gccgacggcg tgtactggca cccagtggcc gccaccgacg agcgcgccct ggtcacccgt
1906141 accgtcgaac ccttgacccc ggcgctggac atggtaagcc ggctattcgc cgaacagtgg
1906201 acacgagccg ccgaagaggc cgcgttgttc ccgtgtgcgt agtgcccagt ctgccggccg
1906261 cgaacccagg attaattgct gatgacaagt attgccctac tgcactatag ttctgcttgc
1906321 acttgaaaac aacgaaccgt gatgcgggtc gtaagggatt ccggtaagga acacagtcaa
1906381 gttcttgcac gcgtcggcgg cagtgttgcc tcaacgccca aactgcacca aactgtttcg
1906441 cccacggcgg ggcgtgtctg agaggtatcg cgtgaccacc gcccataacg gatccgctcc
1906501 gcgttttcaa cgtacccgct ctggctacga cccggtcgca gtcaatcatt acatcgccga
1906561 actcgtgctg cgtcagcagg cgcagcactg tgagattgaa acgctcaagg cagaaatagc
1906621 cagtctgaag gacgaaaacg ctgccctgaa ggacacctcg ccgtcagcac aggcggtgac
1906681 cgatcggatg gcgaaaatgc ttcgactcgc tgtcgacgag gtcttccaga tgcagtcgga
1906741 ggcacgggcc gaggccgcaa cattagtttc tgcggctagg gatgaggcgg aagcggtccg
1906801 aacgcagaag cgagaaatgc tggcggatat gaacgcccgg caaagagcgc tggagtccga
1906861 gcatgccgac gtgatgcgcc gcgctcgtga agaggctgaa cagcttgtgg cgcaggcaac
1906921 cgccgaggtg gagcggatgc gtgtcatcga tgccagacgc cgtgagaaag ccgagcagga
1906981 acttgatgcc gaaatcatca ggcttcgcac cgatgcccaa tttcagatcg acgatcagct
1907041 gcaggccaca cagcaggagt gtgagaagcg gcttggcgaa gccaaaatcg aggccgatcg
1907101 acggctgcat gttgccgacg agcagattga gcacggcctc agcgaggctc ggcgaacgtt
1907161 ggaagagatc agccagcggc gagtcggcat cctcgaacaa ctagcgcgta ttcacgcaca
1907221 gctcgagaat attccagcgc tcctggaatc ggctcgacat agcgagacgg agccactgca
1907281 gtccataaac ggcgcggtcg ctgagctacg ggccatttag cgatcgcgtg cctgagcgcg
1907341 actcatctgt gacagttccg tcacggctgg gtcaggtgcc ggtgtcctgg cgacgccgac
1907401 tgcgcacaga ccgaaacagc acggtgtgga tgtgccatga tgtgcacgct gtcaaggcca
1907461 gtcgggtgac gatgcgggcc ggtgtggtcc gaggaggagc ccgacaattt aagctagtcg
1907521 ggtgacgatg cgggccggtg tggtccgagg aggagcccga caatttaagc tagtcaggga
1907581 gccctcagga gcggtggtgg atctcaattt ttcgatggtc acgcgaccaa tcgagcgcct
1907641 ggtggccacg gcgcagaacg gtctggaagt cctgcgactc gggggcctgg aaaccggcag
1907701 tgttccgtcg ccgtcccaaa tcgttgagag cgtaccgatg tacaagctgc ggcggtattt
1907761 tccgccggac aaccgcccgg gacagccacc ggtgggtccg ccggtgctga tggtgcaccc
1907821 gatgatgatg tcggcggaca tgtgggacgt cacccgtgaa gacggcgcgg tggggatcct
1907881 gcacgccagc gggctagatc cctgggtcat cgacttcggc tcacccgacg aggtcgaggg
1907941 cggaatgcgc cgtaacctgg ccgaccacat cgtcgccctc agcgaggcgg tcgataccgt
1908001 caaggacgcc actggccacg atgtgcactt cgtcgggtat tcgcagggtg gcatgttctg
1908061 ctatcaggcc gcggcatacc ggcgttcgaa ggacatcgcc agcgtggtcg cgttcggctc
1908121 gccggtggac accctggccg cgttgcccat gggcatcccg gcgaacatgg gcgctgcggt
1908181 cgccgatttc atggccgatc acgtcttcaa tcgcttggat atcccaagct ggatggcgcg
1908241 catgggtttt cagatgatgg acccactcaa aaccgcgaag gcccgggtgg acttcgtgcg
1908301 tcagttgcac gaccgcgagg cactgctgcc gcgggaacaa cagcgccggt tcctggaatc
1908361 cgaaggatgg atcgcctggt cgggcccggc gatctcggaa ctgctcaagc agttcatcgc
1908421 gcacaaccga atgatgacgg gtggtttcgc catcagcggc cagatggtga cgcttaccga
1908481 tatcacttgc ccgatactgg cgttcgtcgg tgaggtcgac gacatcggcc agccggcgtc
1908541 ggtacgcggc atccggcggg ccgcgcccaa ctccgaggtc tacgaatgtc tcatccgggc
1908601 agggcatttc ggtctcgtcg tgggatcccg agcggcacaa cagagctggc cgaccgtggc
1908661 cgactgggtg cgctggatct ccggcgacgg caccaaaccg gaaaacatcc acctgatggc
1908721 cgatcagccg gccgaacaca ccgatagcgg tgtggctttc agctcccggg tcgcgcacgg
1908781 catcggggag gtctcggagg ctgcgttggc gctggctcgc ggcgcggccg acgcggtcgt
1908841 tgcggccaac agatcggtgc gcacgctggc ggtggagacg gtgcggacgc tgccgcgact
1908901 agcccggttg ggtcagctca acgaccacac ccggatctcg ctgggccgca tcatcgacga
1908961 acaggcacac gatgccccga agggtgaatt cctgttgttc gacgggcgcg tgcacaccta
1909021 tgaggcggta aaccggcgga tcaacaatgt cgttcgtggc ctcatcgcgg tcggggtgcg
1909081 gcagggtgac cgtgtcggcg tgctgatgga gactcggccc agcgcgctgg tcgccatcgc
1909141 cgcgctgtct cggctgggag cggttgccgt ggtgatgcgg ccagacaccg acctgtccgc
1909201 gtcggtccgg ctcgggagag tgaccgagat cctgaccgac cctaccaatc tggatgctgc
1909261 gcgccagttg cccggacagg tgctggtgtt gggtggtggt gaatcgcgtg atctggatct
1909321 gccggccgac gcacttgaac agggccaagt catcgacatg gaaaaaatcg acccggacgc
1909381 cgtcgagttg ccggcgtggt atcgaccgaa tcccggattg gcgcgggatc tggcgttcat
1909441 cgcgttcagt tcggccgacg gcgacctggt ggccaagcag atcaccaact accgctgggc
1909501 ggtgtcggcc ttcgggaccg cctcgacggc ggccctcggc cgcagagaca cggtgtactg
1909561 tttgacgccg ctgcaccatg agtccgcact gttggtcagc ctgggcggcg cggtcgtggg
1909621 cggaacccgt atcgcattgt cccgcggctt gcgcccggac cggttcgtgg ccgaggtacg
1909681 ccagtacggc gtcaccgtcg tctcctacac atgggccatg ctgcgtgacg tggtcgacga
1909741 tccggcgttc gtgttgcacg gcaaccatcc ggtgcggttg ttcatcggct cgggcatgcc
1909801 gaccggattg tgggagcggg tcgtcgaagc gttcgcaccg gcgcacgtcg tcgagttttt
1909861 cgccaccacc gacggacagg cggtgctggc caacgtggct ggcgccaaga tcggcagcaa
1909921 gggccgtccg ttgcctggcg ccggacgtgt cgaacttggg gcctacgacg ccgaacatga
1909981 cctgatcctg gagaacgacc gcggcttcgt gcaggtcgcc ggtgtcaacc aggtcggggt
1910041 gctgctcgca caatccagag ggccgatcga tccgaccgcg tcggtcaaac gcggtgtctt
1910101 cgctcccgcc gacacctgga tatctaccga ctacctattc tggcgtgacg acgatgggga
1910161 ctactggctg gcgggtggac gcggctcggt ggtgcgcact gcgcgcggga tggtttacac
1910221 cgagccggtc accaacgcgt tgggcctcat caccggtgtc gacctcgcgg tgacctacgg
1910281 tgtattggtg cgcggtcgcc acgtcgcggt gtcggcggtg acgttgctgc ctggagcgac
1910341 catcacagcc gccgacttga ccgaagccgt ggcgagcatg ccggtggggc tgggacctga
1910401 catcgtgcac gtggtgccgc agctaacgct cagcggtact taccggccaa cggtcagcgc
1910461 gttgcgggcc aacgggattc ccaaggcggg ccgtcaggca tggtatttca actccggcgg
1910521 caacgagtac cggcggttga cgccggcggt ccgcaccgag ttgaccggcc agcatcggcg
1910581 cggcaatgct tgacgaggcg ctgctcgcca tcctggtgtg cccggcggat cgaggtccgc
1910641 tcgtcttggt cgaggacggc gacatccagg tgctctataa cccgcggctg cggcgcgcct
1910701 accgcatcga ggacggtatc ccggttctgc tggtcgacga ggcccgcgag gtcgacgagg
1910761 acgagcacgc ccgcctcatg gcgcgaggtc gtccggcagc tccccagtga ggtagcgctg
1910821 caggttgggc gcgatggttt gcacgatctg ttcggccggc aacgaagcaa acggttcgat
1910881 tctgacgatg tagcgcgcca tgaccacacc catcagttgc gacgcgacga actgggtacg
1910941 gatcttgccg gttcccggcg ggttgtcgac gcgggaccca agctccacgg tgaccacttc
1911001 ctcaaggaag gagcgcgcca ggcccacgtc ggagcctgag atcaaggatc tcagcgtcgc
1911061 gatcaacccg gcacccagtt cggaatccca aatcggcagc aacaaggacg gcagcttgta
1911121 accgagttcc tcgacaggcg cctcgcgaat cggaccgatg atgaccatcg ggtcgatcgg
1911181 aatgtggatc gcggcggcga aaagctgctg tttggtgccg aagtagtgat gcactagtgc
1911241 ggcatcaaca ccggccttgg cggccacggc tcggatcgat gttctgtcaa tgccgttgtg
1911301 cgcaaagagt tctcgggcac tggacaggat tcgctcccta gtgtcagagc tgccggcggg
1911361 tcgcccgggc cgtctgcggc tgttgtccgg cgccgccacg ctatgacgtc cgtcgccgca
1911421 gtgtcaccgc cgccagacac agcgacgcga ccgcgaaact cagcacgacg acgacgtcgc
1911481 gcaccgcgat accggtcagc tccggatgcg cacccacctg ttgtagcgcc tcgagcgcgt
1911541 agctggccgg catcacgtta ctgatccact ccagccacgt cggcatcagt gcccgcggga
1911601 cgatgatgcc ggcgagcagc agctgcggca ccatcaccag cgggatgaac tgtacggcct
1911661 gaaattcggt gcgggcgaag gcactacaca atagaccgag cccgacaccc aagacggcgt
1911721 tgacgatcgc gatcgcgaac acccacaccg ggctgcccgc cgtgtcaaag ccaaggaacc
1911781 agaacgccac aatgcaggcc agcgtggcct gcgccgccgc ggcgatcgag aacgcggtcc
1911841 cgtagccggc gagcagatca agccggcgta gcggggtggt caggatgcgc tccagcgttc
1911901 ccgaagccct ttcgcgttgc atggtgatcg ccgtgatcac aaacatcaca aagagtggga
1911961 acaggcccag tagcaccagg caagcggtgt tgaacccgga tggggtaccg gggcgatgcg
1912021 ggacgttctc gaacatgaaa tacatcagcg tgatgatcag gatgggtacc agcaagatca
1912081 tcgcgacact gcggtgatca gcggcaagct gccggagaat ccgcgccgta gtggccgtgt
1912141 agttctgcag cgttagccgg ccgcgggcac ggtggtggtg cgtcggacga tggacagaaa
1912201 cgcttcctcc agtgatgtgc atccggtttc ctttcgtaga cggtgcggcg ttgtgtgggc
1912261 cagcagctgc ccctggcgca gaagcaacag atcgccgcag cggtcggcct cgtccattac
1912321 gtggctggac accaacagcg tggtgccacg ccgcgccagc gccgtgaacc gatcccataa
1912381 ttcgacgcgc aataccggat ccaggccgat ggtcggctcg tcgagcacta gcagatcagg
1912441 ccggccgacc agcgcacacg ccagcgagac ccgggcccgc tggccgccgg acaggttggc
1912501 acaacgggcg gtgcggtgat cgcgcaggtc caccgcttcg atcacctcat cggcggcttg
1912561 cctgtcgacg ccgcagagtt cggcgaagta gcggatgttg tcgatcaccc gcaggtcgtt
1912621 gtaaatggtc gggtcctgag gcatgtatcc aacccgatgg cgtagttcgg ctgacccagc
1912681 cggttggccc agcacgctca ccgaacccga ggcaatgatt tgggagccaa cgatgcagcg
1912741 aatcagtgtt gtcttgcccg acccggacgg accgagcagg ccggtgatcg tgccgcaggc
1912801 gacccggacc gaaacatcct gcagggcaag gcgtttacca cggatgacgc gcagctggtc
1912861 gatgatgacc gcggggtcgg caccgtcgcg aagtaattca tcacttgatg aaatcatcat
1912921 gtgatgaata tccgccagtc gtgcgggttt gtcaagggcc ggtgcacaat cgtctctgat
1912981 gaacgctgag gaactggcga tcgacccggt cgcggccgcg catcggctgc tcggcgcaac
1913041 tattgccgga cggggtgtgc gtgcgatggt ggtcgaggtc gaggcgtatg gcggggtgcc
1913101 cgacggtccc tggccggacg ccgcggcgca ctcttaccgc ggccgcaatg gccgcaacga
1913161 cgtcatgttc gggcccccgg ggcggcttta cacctaccgc agccatggga tccatgtctg
1913221 tgccaacgtc gcgtgcgggc ccgatggcac ggctgccgct gtgctactta gggccgccgc
1913281 catcgaggac ggcgccgagc tcgccacgtc tcggcgcggg cagacggtgc gcgctgtcgc
1913341 actggcgcgc ggcccgggaa acctctgcgc tgccctcgga atcaccatgg ccgacaacgg
1913401 gattgacttg tttgatccgt ccagtccggt gcggctgagg ctcaacgaca cgcaccgtgc
1913461 caggtcgggg ccgcgcgttg gggtcagtca agccgctgac cggccgtggc gattgtggct
1913521 cacgggtcga ccggaggtgt cggcctaccg gcgaagctcg cgggcaccgg cccggggagc
1913581 cagcgactag agtcttgcgg gatgtctggc atgatcctcg atgagctcag ctggcgcggg
1913641 ttgatcgcgc agtcgaccga cctcgacacg ttggccgccg aagcacagcg cgggccgatg
1913701 acggtgtacg ccggcttcga tcccaccgcg cctagcctgc atgccggaca tttggtgccg
1913761 ctgctgacgt tgcggcgctt tcagcgcgcc ggtcatcgcc ccatcgtgct ggccggcggg
1913821 gccaccggca tgatcggtga tccacgtgac gtcggcgagc gcagtctcaa cgaggccgac
1913881 accgtcgccg aatggaccga acggatccgt gggcagctgg agcgcttcgt cgacttcgac
1913941 gactcaccaa tgggcgcgat cgtcgagaac aacctggaat ggaccggctc actatcggct
1914001 atcgagtttc tacgtgatat cggcaagcac ttctcggtca acgtgatgct ggcccgcgac
1914061 accatccggc ggcgtctggc gggggagggg atctcttaca ccgaattcag ctacctgttg
1914121 ctgcaggcca acgactacgt cgaattgcac cggcgccacg gctgcacgct gcagatcggt
1914181 ggtgcagatc agtggggcaa catcattgcc ggcgtccggt tggtgcgcca gaagctcggt
1914241 gccaccgtgc atgcgcttac cgtccccttg gtgaccgctg ccgacggcac caagttcggc
1914301 aaatcaaccg gcggcgggag cctgtggttg gatccccaaa tgaccagccc ctatgcctgg
1914361 taccagtact tcgtgaacac cgcggacgcg gatgtgatcc gctacctacg gtggttcacc
1914421 ttcttgtcgg ccgacgagtt ggccgagctg gaacaggcga cagcgcaacg cccgcaacaa
1914481 cgggccgccc agcgccggct cgccagcgag ctcaccgtct tggtgcatgg cgaggcggcg
1914541 accgcagccg tcgagcatgc cagccgggca ctcttcggtc ggggcgagtt ggcccgtctg
1914601 gacgaggcga cactggctgc tgcgttgcgg gaaaccacgg tcgccgaact caaaccgggc
1914661 agtcccgacg gaatcgtcga cttattggtg gccagcggcc tgtcggccag caagggcgcg
1914721 gcgcggcgca cgatccacga gggtggggtg tcggtcaaca acattcgggt tgataacgag
1914781 gaatgggtgc cgcaaagttc ggacttcttg cacggccgct ggttagtgct acgtcgtgga
1914841 aagcggagta tcgccggggt ggaacggatt ggctgagccg agccaccacg tcctcgacgt
1914901 cctcgggtcc caaggtgata tgcgacgtga gcggcccatg gaatatcgct gggcggtagg
1914961 ggagggccag cgggggatct tatctcgagg gatggggtgg ggatgcatcg ataagccccc
1915021 cgctgaagcc tggggttcga cggggatctc agacttgggg ggattgggag gtgatgagac
1915081 ccccgtcgaa gtctagtgcg ttgacctcac tcggcggtgt cgccggcgtg gaacaacggg
1915141 atcgagtacg tggtctcgct ctcactaaac agctgtgcgt gtgacaacgg gtcatcatcc
1915201 tttcatgtga caggcgagcg gcgttgcgtt gtagtcgatt tccacttcct gacttatctt
1915261 tggcgggttt ggactccgct ggtatcccac gactagtcgg tggccggggg aaatgccgaa
1915321 tcccgcatcc ggtggatcgt gaagtccacc aatcggggga cgatcggccc gcggtgcccc
1915381 cctacccggt taacgcgcac acattccaca cgaaacgcgt tagtgtgcaa acctttatcc
1915441 cactgtgctg tgaacgtgac tcttgttggc cactgttgtc gaggtgcctt aaatgacgca
1915501 agtgcgacaa caacgagaag cgggagatga cggcacacac acacgacggg acacggacct
1915561 ggcgaacggg ccggcaggcg acgacgttgc tcgcgttgct ggccggggtg tttggtggtg
1915621 ccgcgagctg cgcggcgccg atccaggccg acatgatggg taacgcattc ctgacagcgt
1915681 tgaccaacgc cggcattgcc tatgaccaac cggcgaccac ggtggcgcta ggcagatcgg
1915741 tttgtccgat ggtggttgcg ccgggcggga cgttcgaatc gatcacgtcc agaatggctg
1915801 agatcaatgg catgtcgcgt gatatggcga gtacgttcac cattgtcgcg attgggacgt
1915861 attgcccggc ggtgattgcg ccgctgatgc ctaaccggtt acaggcctga tagttacggg
1915921 gcgcagcaac ccccgtaacc tctaccgagt ggtcgacgac aggcaagggc gcaggggcgg
1915981 gcgacgaccg cgctcggctg ccgccgacaa ccgacctgcg ttccgggatg ggcccgcgat
1916041 tccgccgggt atccacgcca ggcaactggc gcccgagatc cggcgcgaac tgagcacctt
1916101 ggaccgtgcc acggccgacg cggtggcatg tcacctagta gctgccggcg agttgatcga
1916161 cgacgaccca gaagccgctc tgcgccacgc gcgggcggcg cgggttcggg ccagcaggat
1916221 cgccgctgtg cgcgaagctg tcggaatcgc cgcctaccgc tgcggcgatt gggcgcaggc
1916281 gttggccgaa ttgcgggcag cccgaagaat ggggagcaag tcccccctgc ttgcgctgat
1916341 cgcggattgc gaacgcggtc tgggccggcc gcagcgggcc atcgaattgg cgcgcgggtc
1916401 cgaggcggtc gagctcagcg gtgacgccgc cgacgagttg cgcatcgtcg ccgccggcgc
1916461 gcgcgccgat ctcgggcaac tggagcaggc gttgacggtg ttgtccacgc cgcagctcga
1916521 cccgggccgt acgggttcga ccgcggcgcg cctgttctac gcctacgctg aaatactgct
1916581 ggcgttgggc cgtggcgacg aggccctgca atggttccta cggtccgcgg cggcggacat
1916641 cgacggcgtc accgacgccg aagatcgggt agacgagcta ggcgcacgag aacagaaatg
1916701 aaaagcattg cgcaggaaca tgactgtctg ctgattgacc tggacgggac ggtgttttgt
1916761 ggccgtcagc ccaccggcgg cgcggtgcag tcgttgagtc aggtgcgcag ccgcaagctg
1916821 tttgtcacca acaacgcgtc gcgtagcgcc gacgaggtgg cggcgcactt gtgcgagctc
1916881 ggcttcaccg caaccggtga ggacgtcgtc accagcgctc agagcgctgc ccacctgctg
1916941 gccggccagc tggcgccggg tgcgcgggtg ctcatcgtcg gcaccgaggc gttggccaac
1917001 gaagtcgccg cggtcggatt gcgtccggta cgacgctttg aggatcgacc cgacgccgtc
1917061 gtacagggcc tttcaatgac caccggatgg tccgaccttg ccgaagccgc gctggccatc
1917121 cgggcgggcg ccctgtgggt ggcggccaac gtcgacccca ccttgcccac cgaacggggc
1917181 ctgctgcccg gcaacgggtc catggtggct gcgctgcgca cggccaccgg catggacccc
1917241 cgagtggcgg gcaagcccgc gcccgccttg atgaccgagg cggtggcccg gggcgacttc
1917301 cgggcggcac tggtggtcgg tgaccggctg gacaccgaca tcgagggtgc caacgccgcg
1917361 gggttgccca gcctgatggt gctcaccggg gtcaacagcg cctgggatgc ggtgtacgcc
1917421 gaacccgtgc gccggcccac ctacattggc cacgacctgc gctcgttaca ccaggacagc
1917481 aagctgctgg cggtggcacc gcagccgggc tggcagatcg acgtcggtgg tggtgcggta
1917541 acggtctgcg cgaacggcga cgtcgacgat ctggaattta tcgacgacgg gctatccatc
1917601 gttcgggctg tggccagcgc ggtatgggag gcgcgggccg ccgatcttca ccagcggcca
1917661 ctgcgcatcg aggccggcga cgagcgggcc cgtgcggcct tgcaacgctg gtcgttgatg
1917721 cgcagcgatc atccggtgac tagcgtagga acgcaatgac catcgatcct gaccagatcc
1917781 gtgccgaaat cgacgcccta cttgcttcgc tgcccgaccc cgccgacgcc gagaacggac
1917841 cgtctctggc cgaactcgaa ggcatcgcac gtcgtctttc cgaggcgcac gaggtgttgt
1917901 tggccgccct ggagtcggcg gagaagggtt gagtgcggcg tggcacgacg tgcccgcgtt
1917961 gacgccgagc tagtccggcg gggcctggcg cgatcacgtc aacaggccgc ggagttgatc
1918021 ggcgccggca aggtgcgcat cgacgggctg ccggcggtca agccggccac cgccgtgtcc
1918081 gacaccaccg cgctgaccgt ggtgaccgac agtgaacgcg cctgggtatc gcgcggagcg
1918141 cacaaactag tcggtgcgct ggaggcgttc gcgatcgcgg tggcgggccg gcgctgtctg
1918201 gacgcgggcg catcgaccgg tgggttcacc gaagtactgc tggaccgtgg tgccgcccac
1918261 gtggtggccg ccgatgtcgg atacggccag ctggcgtggt cgctgcgcaa cgatcctcgg
1918321 gtggtggtcc tcgagcggac caacgcacgt ggcctcacac cggaggcgat cggcggtcgc
1918381 gtcgacctgg tagtggccga cctgtcgttc atctcgttgg ctaccgtgtt gcccgcgctg
1918441 gttggatgcg cttcgcgcga cgccgatatc gttccactgg tgaagccgca gtttgaggtg
1918501 gggaaaggtc aggtcggccc cggtggggtg gtccatgacc cgcagttgcg tgcgcggtcg
1918561 gtgctcgcgg tcgcgcggcg ggcacaggag ctgggctggc acagcgtcgg cgtcaaggcc
1918621 agcccgctgc cgggcccatc gggcaatgtc gagtacttcc tgtggttgcg cacgcagacc
1918681 gaccgggcat tgtcggccaa gggattggag gatgcggtgc accgtgcgat tagcgagggc
1918741 ccgtagtgac cgctcatcgc agtgttctgc tggtcgtcca caccgggcgc gacgaagcca
1918801 ccgagaccgc acggcgcgta gaaaaagtat tgggcgacaa taaaattgcg cttcgcgtgc
1918861 tctcggccga agcagtcgac cgagggtcgt tgcatctggc tcccgacgac atgcgggcca
1918921 tgggcgtcga gatcgaggtg gttgacgcgg accagcacgc agccgacggc tgcgaactgg
1918981 tgctggtttt gggcggcgat ggcacctttt tgcgggcagc cgagctggcc cgcaacgcca
1919041 gcattccggt gttgggcgtc aatctgggcc gcatcggctt tttggccgag gccgaggcgg
1919101 aggcaatcga cgcggtgctc gagcatgttg tcgcacagga ttaccgggtg gaagaccgct
1919161 tgactctgga tgtcgtggtg cgccagggcg ggcgcatcgt caaccggggt tgggcgctca
1919221 acgaagtcag tctggaaaag ggcccgaggc tcggcgtgct tggggtggtc gtggaaattg
1919281 acggtcggcc ggtgtcggcg tttggctgcg acggggtgtt ggtgtccacg ccgaccggat
1919341 caaccgccta tgcattctcg gcgggaggcc cggtgctgtg gcccgacctc gaagcgatcc
1919401 tggtggtccc caacaacgct cacgcgctgt ttggccggcc gatggtcacc agccccgaag
1919461 ccaccatcgc catcgaaata gaggccgacg ggcatgacgc cttggtgttc tgcgacggtc
1919521 gccgcgaaat gctgataccg gccggcagca gactcgaggt cacccgctgt gtcacgtccg
1919581 tcaaatgggc acggctggac agtgcgccat tcaccgaccg gctggtgcgc aagttccggt
1919641 tgccggtgac cggttggcgc ggaaagtagc ggcgcgccga aggtgttgac tgaattacgg
1919701 atcgagtcgc tgggcgccat cagcgttgcc accgctgagt tcgatcgcgg ctttaccgtg
1919761 ctgaccgggg agaccggcac cggcaagacc atggtggtga ccgggctgca cctacttggt
1919821 ggtgcccggg ccgatgcaac tcgcgttcgg tccggtgctg accgtgccgt tgtcgaaggg
1919881 cgttttacta caaccgatct cgacgacgcg accgtcgcgg ggctgcaggc ggttctcgac
1919941 tcgtcggggg ccgagcgcga cgaggacggc agcgtgatcg cgttgcgctc gatcagtcgc
1920001 gatggaccgt cgcgcgccta cctcggcggc cgcggtgtac ccgccaaatc gttgagcggt
1920061 ttcacgaacg agctgcttac tctgcacggg cagaacgacc agctgcggtt gatgcgcccg
1920121 gacgaacaac gtggtgcact ggaccgcttt gcggccgctg gcgaagccgt ccagcgttac
1920181 cgcaagctgc gggatgcctg gctaacggcc cgacgcgacc tcgtcgaccg tcgcaaccgg
1920241 gcccgggaac tagcgcaaga ggccgatcgg ctgaaattcg cgctcaacga gatcgacacc
1920301 gtcgacccgc agccggggga ggacgtggcg ttggtcgccg acatcgcccg gctttccgaa
1920361 ctggacaccc tgcgggaggc cgcgactact gcacgcgcga cgttgtgcgg gacaccagac
1920421 gcggacgcat tcgaccgcgg cgccgtcgac agcctcgggc gggcacgtgc ggcactgcaa
1920481 tcgagcgatg atgccgcgtt gcgggggttg gccgaacagg tcggtgaggc gttgacggtg
1920541 gtcgtcgatg cggtcgccga gctcggcgcc tacctggacg agctgcccgc cgacgccagc
1920601 gcgctggacg ccaagctggc gcgccaagcc cagctgcgaa cgttaacccg caagtacgcc
1920661 gccgacatcg atggcgtgct ccggtgggcg gatgaggcga gggcaaggct ggctcaactc
1920721 gacgtctccg aagaagggct ggcagcgctg gaacgccgta ccggtgagct cgcccacgaa
1920781 ttaggccaag ccgcagttga tctcagcacg atccggcgga aggcggccaa gcggctggcc
1920841 aaggaggtca gcgcggagct gtccgccctg gcgatggccg atgccgaatt caccatcggt
1920901 gtgaccacag agctggccga ccacggcgat cccgtcgcct tggccctggc gtcgggcgaa
1920961 ttggcccggg ccggtgccga tggcgtcgat gcggtcgagt tcggtttcgt cgcacaccgg
1921021 gggatgacag tgctgccgct ggccaagagc gcatccggcg gcgaactgtc ccgggtgatg
1921081 ttgtccctgg aggtggtgct ggctacttcg cgaaaacaag cggctggcac cacgatggtg
1921141 ttcgacgaga tcgacgccgg cgtcggcggc tgggctgcgg tacagatcgg gcggcggctg
1921201 gcgcggttgg ctcgcaccca ccaggtcatc gtggtcaccc atctgccgca ggtcgccgcc
1921261 tatgccgatg tgcacttgat ggtgcagcgc accgggcgcg acggtgccag cggtgtgcgg
1921321 cgcctgacca gcgaggatcg ggtggccgag ctggcacgga tgctggccgg gcttggtgat
1921381 tccgacagtg gtcgcgcgca cgcgcgggag ttactcgaga ccgcgcagaa cgacgagctc
1921441 acctagcaag gctgtgactg aagtgatgtc atataacttg tgaggctaat gttacggcgc
1921501 gcctccacgc acctgcccag cttcaccgcc agaatccccc catgaggatg tcagcgcttc
1921561 tgtcccgtaa cacctcccgg ccgggcctga tcggcatcgc ccgggtcgac cggaatatcg
1921621 accgattgct gcgtagggtc tgtcccggcg acattgtggt tctcgacgtc ctggatctgg
1921681 accgcatcac cgccgatgca ctggtggaag cggagatcgc cgccgtggta aacgcatcgt
1921741 cgtctgtctc gggccgctat ccgaacctcg gtccagaggt gttggtcacc aacggtgtca
1921801 cgctgatcga cgagaccgga ccggagattt tcaaaaaggt caaagacggt gccaaggttc
1921861 gcttgtatga aggcggggtg tacgccggcg accgccggct gatccgcggt accgagcgta
1921921 cggatcatga catcgccgac ctgatgcggg aggccaagag cgggttggtc gcccacttgg
1921981 aggcgttcgc cggcaacaca attgagttca tccgcagtga aagcccgcta ttgatcgacg
1922041 gcatcgggat tcccgatgtc gacgtcgatc tgcggcgtcg gcacgtggtg atcgtcgccg
1922101 acgaacccag cggacccgat gacctgaagt ccctcaagcc gttcatcaag gagtaccaac
1922161 cggtgctggt tggtgtgggc accggcgcgg acgtgttgcg caaggcgggg tatcgcccgc
1922221 agctcatcgt cggcgaccct gaccaaatca gcaccgaggt gctcaagtgc ggtgcccagg
1922281 tggtgttgcc cgccgacgcc gatggacacg cgccgggcct ggagcgaatc caggatctcg
1922341 gtgtcggcgc catgacattc ccggccgcgg gctcggcgac ggatctggcc ttgttgctgg
1922401 ccgaccatca tggcgcggcg ctactcgtca ccgccggcca cgctgccaac atcgagacgt
1922461 tcttcgaccg cacgcgtgtg caaagcaacc cttcgacctt cctcaccaga ctccgggtag
1922521 gggagaagtt ggtggacgcc aaggcggtgg ccacgctcta ccgcaaccac atctcgggcg
1922581 gcgccatcgc attgctggca ctgaccatgc tgatcgccat catcgtggca ctgtgggtat
1922641 cccgcaccga cggcgtggtc ctgcattgga tcatcgacta ctggaaccga ttctcacttt
1922701 gggtgcagca cttggtctcc taggttttct tggacggtgg gttcatgatc tcgttgcgtc
1922761 aacatgcggt ctcactggct gcggtcttcc tggcgctggc catgggcgta gtgttgggtt
1922821 ccggcttttt ctccgatact ttgctgtcca gcttgcgtag cgagaagcgg gacctctaca
1922881 cgcagatcga ccgactcacc gatcagcggg atgcacttcg cgaaaagctc agcgcggcag
1922941 acaatttcga tatccaagta ggcagccgaa tagtgcacga cgcgctagtc ggcaagtcgg
1923001 tggtcatctt ccgcaccccg gatgcccacg acgacgatat cgctgcggtg tcgaagatcg
1923061 tgggacaggc cggcggtgcg gtcaccgcaa cggtctcatt gacccaggag ttcgtcgaag
1923121 ccaactccgc cgagaaactg cgctcagtgg tgaactcgtc cattctgccg gccggtagcc
1923181 agttgagcac caaactcgtt gaccaaggtt cccaagccgg cgacctgctc ggcatcgcct
1923241 tgctgagcaa cgccgacccg gcggcgccga ctgtcgagca ggcgcagcgg gacactgtgc
1923301 tggcggcact gcgcgaaacc ggcttcatca cctatcagcc ccgcgaccgc attgggacgg
1923361 caaacgccac ggtggtggtc accggcggag cgctctctac agacgccggc aaccaggggg
1923421 tcagcgtggc tcggttcgcc gcggcgctgg cgccgcgcgg gtctggcacg ctgcttgccg
1923481 gccgggacgg ttcggcgaac cgacccgccg ccgtcgccgt gacccgcgcc gatgccgaca
1923541 tggcggccga aatcagcacc gttgacgaca tcgacgccga gcccggacga atcaccgtga
1923601 tccttgccct gcatgacctg atcaacggag gccacgtggg gcactacggc accggtcacg
1923661 gggcgatgtc agtcacggtt tcccagtagg cccgcgttag ggcgtgttcc ccgcggtgag
1923721 gcgccgtgga tgttagggtg ggtttccgtg ggtcggcagg cccagcaagg ccagagaaat
1923781 cttggcagcg tcaagaacag ccctgcccgt cttcacggag gtcgctcagt gcgaaagcac
1923841 ccgcaaaccg ctaccaagca cctcttcgtc agcggcggcg ttgcttcctc gctcggcaag
1923901 ggactgaccg ccagcagcct aggacaattg ttgacggctc gtgggttaca cgtcacgatg
1923961 caaaagctcg acccgtacct caacgtcgac ccgggtacca tgaacccgtt ccagcacggc
1924021 gaggtcttcg tgaccgagga cggtgccgaa accgatctcg acgtcggcca ctacgaacgg
1924081 ttcctcgatc gcaatttgcc cggctcagcg aatgtgacta ccgggcaggt gtattcaacg
1924141 gtgatcgcga aggagcgccg cggcgaatac ctgggcgaca ccgtgcaggt gatcccccat
1924201 atcaccgacg agataaaacg gcgcatcctg gcgatggccc aaccggacgc cgacggtaac
1924261 cgcccggacg tggtcatcac cgaaatcggg ggcactgtcg gcgatatcga gtcacagccc
1924321 ttcctggagg cagcgcggca agtccggcac tatctcggcc gggaggacgt gttttttctg
1924381 cacgtgtcgc tggtgcccta cctggcgccg tcgggtgagc tcaaaaccaa gccaacacag
1924441 cactcggtgg ccgcactgcg cagcattggg attaccccgg acgcgttgat cctgcgctgc
1924501 gaccgcgacg ttcccgaagc gctgaaaaac aagattgcgt tgatgtgtga cgtcgatatc
1924561 gacggcgtta tctccacccc ggacgcgccc tccatctacg acatacccaa ggtattgcac
1924621 cgcgaggagc tcgatgcgtt cgtggtgcgc cgactcaatc tgccgttccg cgacgtcgat
1924681 tggaccgaat gggacgacct gctgcgccgg gttcacgaac cacatgagac agtgcgaatt
1924741 gctttggtgg gcaagtacgt cgaattatcc gacgcttacc tctcggttgc cgaggcattg
1924801 cgtgccggcg gattcaagca ccgggccaag gtcgagatct gttgggtggc atccgacggt
1924861 tgtgaaacga ccagtggtgc cgcggcggcg ctcggcgatg tgcatggggt gctcattccg
1924921 ggcggattcg gcatcagggg catcgagggc aagatcggtg ccattgcata cgcgcgggcg
1924981 cgcgggttgc cggtgttggg gctgtgcctc ggtttgcagt gcattgtgat cgaggccgcg
1925041 cgatcggtcg gtctcaccaa cgccaattcg gccgaatttg atcccgacac accagatccc
1925101 gttatcgcca cgatgcccga tcaagaagaa atcgtggccg gcgaggcgga tctgggcggt
1925161 accatgcgtc tcgggtccta ccccgccgtg ttggagccgg attcggttgt tgcccaggca
1925221 taccaaacta cccaggtgtc cgagcggcat cgccaccggt acgaggtcaa caacgcgtac
1925281 cgagacaaga tcgccgaaag cggcctgagg ttttccggga cgtcacctga cggacacttg
1925341 gtagagttcg tcgagtatcc gccggatcgg catccgttcg ttgtcggcac ccaggcccac
1925401 cccgagttga agagccgacc cacccggccg cacccactgt ttgtcgcatt cgtcggggca
1925461 gccatcgatt acaaggcggg tgagttgctg cctgtcgaga tccccgagat ccccgagcac
1925521 acacccaacg gtagctccca tcgggacggc gtgggccagc cgctaccgga acctgcgtct
1925581 cgtggctgag catgatttcg agacgatatc gtcggaaacc ttgcatacgg gagccatttt
1925641 cgcattacgt cgggaccagg tgcggatgcc tggtgggggt attgtgacgc gtgaggtcgt
1925701 cgagcacttc ggtgccgtag ccattgtggc gatggacgac aacggcaaca tcccgatggt
1925761 ttatcagtac cgccacacct atggtcggcg gctttgggaa ctgcccgcgg ggttgctcga
1925821 cgtcgctggg gagccacctc atctcacggc cgcccgggag ctgcgggagg aggtcgggct
1925881 gcaagccagc acctggcagg tgctggtcga tctggacacc gcgccgggct tcagcgacga
1925941 atcggtgcgg gtctatctgg ccaccggact gcgcgaggtg ggccggcccg aagcccatca
1926001 cgaagaagcc gacatgacga tggggtggta tcccattgcc gaagcggctc gccgggtgct
1926061 gcgtggcgaa atcgtcaatt ccattgccat tgccggtgtt ttggccgtgc acgcggtgac
1926121 gaccgggttc gcccagccac gcccactcga taccgaatgg atcgacaggc caacggcgtt
1926181 cgccgcgcgg agagccgagc gatgaagacg ctggcactgc aattgcaggg ctacctcgac
1926241 catctgacga tcgaacgagg tgtcgcggca aacacattga gctcctaccg acgtgatctg
1926301 cgccgctact ccaagcacct ggaagaacga gggattaccg atctggccaa ggtcggcgag
1926361 cacgacgtca gcgagttcct ggtggcattg cggcgcgggg atcctgattc cggcacggcg
1926421 gcgttgtccg cggtgtcggc ggcacgggcg ctgatcgcgg tgcgcgggct gcatcgcttc
1926481 gctgccgcag aagggctggc cgaactggac gtggcgcgcg ccgtccggcc accgacgccg
1926541 agccggcgat tgcctaagag cctgacaatc gacgaggtgc tatcgctgct cgaaggtgcg
1926601 ggcggcgata aaccgtccga cggcccgctg acgctgcgaa accgtgcggt gctggaactg
1926661 ctgtactcga ccggggcgcg gatctccgag gccgtcggcc ttgacctcga cgacatcgac
1926721 acccacgcca gatcggtgtt gttgcgcggc aagggtggta agcagcggct ggttccggtg
1926781 ggacgcccgg cagtgcacgc gctggacgcc tatctggtgc ggggacggcc cgacttagcg
1926841 cggcggggcc gcggaacggc ggcgatcttt ctcaacgcgc gcggcggccg gttgtcacgg
1926901 caaagcgcgt ggcaggttct gcaggacgcg gccgagcgtg ccggcatcac cgccggtgtt
1926961 tcgccgcata tgttgaggca ttcgttcgcc acgcatctgc tggagggtgg cgccgatgtc
1927021 cgggtggtgc aggaattgct ggggcacgcc tcggtgacca cgacgcagat ctataccctg
1927081 gtcaccgtcc atgcactgcg cgaggtgtgg gcgggagctc acccgcgggc acgctaagcg
1927141 atgaccgtca ctagcggtag cggttgctgg tcacttggct cgcccgcgac acagaggttg
1927201 cgcctctcgc tcatggatcg tcttcgtcgc tgtcgtgcag gagtttttcg gggtgaaagt
1927261 aactgttggt gcggggttgt ccatggtcga ggtgggctgg gggaagccat tcggtggtgc
1927321 cgtctttgcg tttgcgggtg atccagcccc cggtggtggc cagttggtgg tgggggccgc
1927381 agccctgggt gagttcgttg atgtcggttt cttggcattg ggcgaagtcc gtcacatgat
1927441 gcacctcggt gagatagccc ggtacgtcgc agttggggaa cgagcagccg cggtccttgg
1927501 cgtagaggac gattcgctgt ccgggtgagg ctagccgctt ggtgtgatag agggccagct
1927561 cgcggccgtg gtcgaagata cgtaggtagt ggttggcgtg gctggccagc cggatcacgt
1927621 cgctcatggg cagcagggtg ccgccgccgg tcagcgcgtg gccggcgcgt gattgcagtt
1927681 cggtcaggct ggtggacacg atgatggccg cgggtagccc gttgtgttgg cccagctccc
1927741 ccgagcacag cagggcccgc agcgcggcca gcaggccgtc gtggtggcgt tggccggcgc
1927801 tgcgggtgtc ggcctcgatc gcggcctgtg acggggtgcc ggccaggcag ggggtgtcat
1927861 cggcggggtt ggccatgccg ggggcggcca gcttggccaa cacggcgtcg acggtggcgc
1927921 gggcttcggg ggtcaggtag ccgctgatcg ccgacatgcc gtcggggcct tggttgccca
1927981 ggatgatgct gcggcggcgg gcgcggtcgg tgtcgttgta gttgccgtcg gggttcaaac
1928041 agtcggcgag tttggtggct agtttgtgta gttggtcggg gcgaaaccgg ccgcctaggg
1928101 tggccagctc ggcttcggct ttctcccggg tgggtaggtc cacatggtgg ggtagctggt
1928161 gcaggaagca gcggatgacc tgcacgtggg cggggccgag gtggccggcg cgttgggcgg
1928221 cggcggtggc ggtcagcaac gggggcaggg gttggccggt tagcgtgcgg cgtgggccca
1928281 ggtcggcggc ttcatggatg cgtcgggatg cttcgccgcg gctgatgtgt agccgttcgg
1928341 ccagggcgaa gggtagtttg ccgcccagtt cggtttggtc ggtttggtcg gcgagtttgt
1928401 tgatgaaggg gtgttcggcg gcgggtaggc gccgacggat cttttcgcag cgctgcagca
1928461 ttgccaggca ttccgggatg gtcaggtcgt caggggagac cttcaggacc cggttaaggg
1928521 cggtgtcgag gttgtcgaac gcggcgacgg cctcctcccg gctactcgaa tacatgttcg
1928581 aatactatca cggttagccg gccgatgcca tgctgattgt gggttaatcc aatgtggtgc
1928641 agttgaattc aggagcatcg ccagccgcga ggccacgcct attcggcgag cataatggtc
1928701 ggctcggaga catccagcaa catgaggcga tgaagacatc acgtgcgatg ggtggtcacg
1928761 gtgggcagct ctgacgcgct gtttcgcgta gtcgacggcg tgcaggtagc cccggccttg
1928821 acacgttccg gcccgctcaa gcgagtagtc cgcggatgtc gtcgacggtg ggtacggagc
1928881 cgaaggcgtt gccgtcgtcg acgacgctgg cgaataggtt tgaggtccag cccgaagccg
1928941 cgggcttgag gctgatgagg aaaaccggcg cgttgcgctc gttgaactgc tggatcacat
1929001 tggggcgtca tcgaggtcga tcgacggata catcagggaa tgcatggccg caccgtatcg
1929061 actcggtctg acagccatcc gcagccacac cgcaaccgca cgcgatgacc aatcgacgac
1929121 taaccgtcga ctaacccagg tattcggact ccaataccaa gtcgggcacc agggtctggt
1929181 attcgaggtg cgtcttgtgc tcaatggtgt tccatgacat gccttgttgc cggcgcatat
1929241 atgcacggta cttcggcgcg ccgggcaccc tgacattgtc ggcaaccacg atcgagcccg
1929301 ggtgcaacca gccccggtct aggatgctct gcagatcggg caggtaagcc ttcttgtcat
1929361 ggtcgaggaa cacaaaatcg agtgtgccag ttgcgaatcc gtgctcggtt agcgcgtcca
1929421 gggtgcgccc accgtcgccg atggtgccga ccacgcacac caccctgtca tcgacgccgg
1929481 catgcgccca tattcgccgg gcgttgctgg cgttggcttc ggcgagttcg acggagtaca
1929541 ccctggcctc cggagcggcc cgggcgatcc gcagcgcgcc gtagccgagg taggtgccca
1929601 actccagcgc caatgccggg tcggcgcgcc gaaccgccgc gtcgagcagc gtccctttct
1929661 cgtcaccgac gttgatgagc atcgacttct cataggcgaa cttgtcgatg gtggccagca
1929721 cgtcgtcgat gttgccggcc ccggcgtggg cgaggacata gtcgacggcc gccgcttcgc
1929781 gtccatcacc gatctggccc gtcgtggtga tattgcggat cccggccgcc atccgccaga
1929841 ccgaccaccg caacggggca atgcgcgctt tgcgaatcat cgctcgctag cttacgcaca
1929901 gatttcgcgg acctgcgggc acctggttca cctgctgaca ctggctcgac gacgaccgca
1929961 cttcggagtt tgggccgcgc gtggattttc attgcaagcc tggccatacc gcggccgagc
1930021 tgctgacgaa ccccgacgac ctggcagtga aaaccaaagc tgcggcggct ctgccggcgc
1930081 tgggtgacga gccaacccac ggcgagcagc acgaaccata gcgggaacca cgccaacgcg
1930141 gttgcggttt cggtttcggt ggtaagtgtc cagatcacga acgcgaaaaa caccagcacg
1930201 gcccagcaca tcaccacgcc accgggcatc ttgtacaccg agtcggtgtg acgctgtggg
1930261 tgtcggcgac ggtagacgag gtagctgatg atgatcattg cccacacaaa catgaacagc
1930321 agggatgaga ccgtcgtgac gagtgtgaac gccccaatca ccgaccgacc ggcatagagc
1930381 agcgggatgg aggtcagcag tagcggagcc gtcagcagca gggcgggtgc gggcacgccg
1930441 ccgcgattga gttggtggaa agcggccgga gcgtggcctt cgtcggcgag gccgaaaagc
1930501 attcgcccgg tggagaagaa gccggagttc gctgacgagg ccgctgcggt gaccacgacg
1930561 aagttgacga ccgacgccgc agcggcaagt ccggctaggg agaacatcgt cacaaacggg
1930621 gactcgccac tggcgaactg ccgccacggc acgacggcca ggatcgccag cagggcaccg
1930681 atgtagaaca ccgcgacccg caacggcacg gcattgatcg cgcggggaag ggtgcggcgc
1930741 gggtccgctg tctcagccgc ggcggtgcca acgagctcca caccgatgta tgcgaaaaac
1930801 gcgatctgaa agccactgac cacgcccagg aaacccgttg ggaagaaccc gttgtcgttc
1930861 cacaggttct cgatggtcgc gtgcacacca tgaggggaga cgaagttggt tgccaccagg
1930921 atcgcgccga cggcgatgag gcacacgatg gcagcgacct tgatcaatgc gaaccaaaac
1930981 tccagctccc cgaagtggcg gacgctgaac aaattgacag cgagaatcag ggcgaccgtg
1931041 accagggccg ggacccagat tggcaagccg ggccaccaaa acctggcata gccggtgatc
1931101 gcgacgaggt ctgcgatccc ggtgaccacc catgcgaacc agtacgacca ccccacgaaa
1931161 aagcccgccg ccgggccccg gaggtcggcg gcgaagtcaa cgaacgactt gtagttcagg
1931221 ttcgacagca gcagctcgcc catcgcgcgc aacacaaaaa acacaaaaaa cccaatgatc
1931281 ccgtagacca ccatgaccgc cggaccggcg agcgagatcg ttcgcccaga tcccatgaat
1931341 aggccggtgc cgatcgcgcc tccaatcgcg atcaactgaa tatggcggtt ggcaaggtcc
1931401 cgacgcaggt gcggctgggt gtctgtcggg tcggcagccg cgatatcgtc cggcatatat
1931461 ggcgtcctcg agttctgggg tagggaaggc ctcgcgttat ccggcaaacg gcggccggga
1931521 catcaccgta acccggaacc cgtagcgggg acccgcaccc cccgtaccgg tgcccgaacc
1931581 ggctagcggc atgccgccca acaggtttcc cgccgcaccg gcctccggtt gctcgacgat
1931641 atcgctgacc aggggtgcgg aggccgaacc cacggtcggg gctaggctcg gactggcccc
1931701 tgcccagttg ggcggcagcg ataacttgcc gatggtggcc gcgttgccta gacccgcgga
1931761 tacgggtccg gtaccgccaa ccgcggcgcc gacggccgcc ggcgccgcgg cggcagcttc
1931821 ggcggcctcg ggaccgatcc atcccagcgc ccgccacgat gtaataaggc tgttgccaat
1931881 accaatggcg aaatatggca aacccacggt gttgtaaaac agctgtgata tcggcagata
1931941 ccagttgatg aaccattcca gccaccccgg ggtcgcggcg gcggtcaacg cggacgacag
1932001 gggcgaggtg aggcccagca gcgtgttggg caagtgggcg atcagctccg ctattgcgct
1932061 ctgcgccgcg ccggctgagg tgccggcggc tttggcgact gcggacaact gcgtcgccgc
1932121 ggcggatggg ctggtggtgt tcggcggcgg ggcaaacggc gtcactttgg tcgcggtcgc
1932181 cgaggagccc gcgtaaccgt acatggccat ggcgtcttgg gcccacattt cagcgtattg
1932241 agcttcggtg gccgcgattg atgcggtgtt ttgaccgaac acgttatgcg tgaccagcga
1932301 cgtgagccgc gcgcgattgg ccgcgatcag cggcgggggc acaatggcgg caaacgcggt
1932361 ttcgtaagcg gccgccgccg cacgcgcctg actggctgcc tgctcagctt ggatggcggt
1932421 ggctcgcatc cacgccacat acggggcgac cgcttcgacc atcaacgtcg acgccggacc
1932481 cagccattct tcggtttgca gcgtcgtgat cacccgctcg tagccgacgg cggccacact
1932541 gagctcggcg gccagcccgt tccacgcgga cgctgcggca accatcggtg ccgagcccgg
1932601 gccgcaatac atgcgcccgg agttcacctc cggtggcaac gccccaaaat ccatcgctat
1932661 gaactcctta cctcgtcacg ggttttcggt gggctatccg acgttcggcc ggtcagccat
1932721 cacggtgagt cgtcttccat atcggcgtcc catatgggcg gcgcgactcc tgcccggagt
1932781 cggtgccccc cggagtagga ccgatgtttc agccgcctcg gcggcgctgc gaataccggg
1932841 aatcgatcgc gcgacggttt gcgcctgggg cgtggcgggc ggtgcggacc agcccggcgg
1932901 caccgacatc ggtccgatct tggcggccag agtcgcgctc gccgccaccg gtccagctcc
1932961 cagctgcgac cacgccgacc atccagcggc tccacccgcg ccggccgctg cctcggccgc
1933021 accggcttct gccaatgcgg tgctccacaa catcccgccg acgaactgca gagcattcag
1933081 cgttaaccca ccgctgtcgt aaatgaaccc ttcggcagtg gcgagggcgc ccaggaacat
1933141 catccagtat ttctgtatgt cgctccatgg aatcgccgcg gcccagctgt gctgcccccg
1933201 cagcgcggcc accgctgttg cgtggccgac gaggccggtc gcgttggtgg tttgcggcgg
1933261 tggtgcgaac ggagtcaaaa ccgtggcggg tgccgcggcg ctggcatagc cgtacatcgc
1933321 ggcggcgtct tgggcccaca tctcggcgta ttgggactcg gtggtggcga tcgccggcgt
1933381 gttttgcccg aaccagttgg tatcgacgag cgtcatcaac aaggtccggt tggccgcgat
1933441 cgccggcggg ggcaccgtca tggcgaaggc ggcttcaaag gccgctgcgg ccgccctagc
1933501 ctgcatcgcg gcctgttcgg ctagcgtcgc ggtggtactc agccagccga caaagggcag
1933561 gacggcggcc accatcgaat ccgatgccgg ccccgaccac caccgcatgt ttgtcagctc
1933621 cgagatcgcc gcaccgtagc cagtcgctgc cgacgacaac tctgcggcca gcccgtccca
1933681 ggccgccgcg gcagccatca gtggcccgga tcccggaccg ctatacatac gacccgaatt
1933741 gatctcggga ggtaacgccc caaagttgga cagggaatgc ccggcgatgc cgtcagcaac
1933801 ggcggtgacc ccaacaaggc agcaggcgac gctgcccggg gggacatgcc cctggttgac
1933861 cgggacatcg agggtcatcg aaaaccgcct cgttatgggt gggctggctc gacaccgtcg
1933921 tcgatacgat agctatgact agggcaacag tgacctagca cgttaatctc cataagagat
1933981 cttctgcgaa aaaggtttcg gccgtgtgac gcgcgtgtta ataccccata ggggtataat
1934041 cgttactgtt ggcaacgtct ggcgtcctgg ctcgggcgac acaccgtccc gatacatgtc
1934101 agcaaccggg tcgatcgtgg tgaatgcaca ggcgggcaag gcgaatgccg atgcgacccc
1934161 gacgaagtaa gagggtacgt aatcgataca ccatggggac atttgccctc catggcctca
1934221 cccatcgcct accgtcggcc tcgttgcaga cgacggctgc ccgccacccg gatgtgacgc
1934281 aattctcaat gcctgggcac taccgataac gccgacctgc cgcagctcgc gcatgtggac
1934341 gctgaaagcc cggaaggagc acaccggcat atccggcaag cccaccgcac ggaccgatcg
1934401 ccatggctct actcggtccg gagattctga gctacaagct agtgcgcggc gtttttctcg
1934461 attgccggat cgctgtggcg ctcagggcgt tacgtgaaag gttcggcagc ggtgctgccc
1934521 agcctggccg gtggcgaaca cggtcaacat ggtgaggccc tgcggcaccc gaaatgcggt
1934581 gagcagaacg acgtttggtg ccatcgcgga tagcagccag ccaagcttga acgctgcgag
1934641 cgagcccatg tagagcgttt ggtaccaaac cgatcggtgg gccaacttgc catgggctca
1934701 cagcggctat cgcgagcgtg tagccgatca tcgtccaggc gacggtggcc tgagcggcag
1934761 gggttgcctt attcatcctc ttgcggcatg gttgccgcag ggagtgccgg taagtctggt
1934821 cggcaacctg gcccgctgcg ggttgggttc ggattcgctc ggctagtaag gtgctcgcct
1934881 ggtgttacaa cgaatcgcta gagagctctt atcgggagtg gccgtcgcga tcgttgcgct
1934941 gccgctggcg atcgcgttcg gcattaccgc caccggaacg tcccaaggtg cgctcatcgg
1935001 gctctacggc gccatcttcg ccggattctt cgcggccgtg ttcggtggga cacccggaca
1935061 ggtgacgggc cccaccggcc ccatcaccgt cgtcgctacc gcaaccatcg ccgaacacgg
1935121 actcgagggt gccttcttcg cgtttatcct cgccggcgtc tttcagatcc tgttcggggc
1935181 gtgccggctc ggttcactca tccgctacgt gccccacccc gtgatctctg gattcatggg
1935241 gggaatcgcg atcctcatca tcatgaccca gctggatcag gtgcgcagca gctccctgct
1935301 cgtgttggta acggtcgtcc tgctgctggc tagcggccgg tttatcaaag cgattccacc
1935361 gagcctgctc gtcctggttc tggtcagctc ggtgctgccg ctcgcggcgc catggctgcg
1935421 cgacctgcgc gctgggccgg tctcgatcaa caggacggtc gactacatcg gcgagatccc
1935481 acaggccatg ccgtctttcg acttcccgca agtcgccaat tcgacgatgc tgcaggtgct
1935541 gctgtcggcg gtggccatcg cgctgttggg atccctcgat tcactgctga cgtcgctggt
1935601 catggacaac atcaggggca cccggcaccg gagcaacaaa gaactgatcg gccaggggat
1935661 tggaaatatc gccgccgggc tcttcggcgg gctgtccggt gccggcgcga ccgtccgatc
1935721 ggtggtgaac gtcagaaatg gtggtcagac cgccctgtcg gcggccactc acagtgtcgt
1935781 tttgttcgtt ttcgttgccg ggcttggtgc cgtggtgcag tacatcccgc tcgccgtgct
1935841 gtcggggata ctgatattgg ttgccgtcgg catgttcgac tggcacgcca tgcgcaaagc
1935901 gcatgtgtca cccaggggcg acgtcatcgt catgttcacg acgatgatca tcaccgtcgt
1935961 cgtcgacctc accatcgcgg tgatggtcgg aatcgccctc tcgctgctgg tccataggct
1936021 ccgatcccgg caacgcaaag ccaaggtcac ccaggacgac accggcacct atcgcatcga
1936081 cggtccgttg tcgttcctgt ccgtcgacgg tgtatttggc tccctgcgcg acggtcgtga
1936141 ggacgtgtcg ctggacctcc agcacgtcac ctacctcgac acctctggtg cccgggccct
1936201 gctgtatttc atcgaccact ccgagaagga cggcgtcgcg gtaagcatca agcggatccc
1936261 cccacgcctc gaaagccaac tcaccgcact cgccgacaac gagcaacgtg acaagctgag
1936321 aaccgtcctc gaatccgcct gacgcattgg ctggttgatt tgcctgcggg tctcccgggc
1936381 caggcgtcgg tagccgttag actttcctgc gatgtccccc ctgacgcccg tcaccacgag
1936441 ccacgaccgg gtatgaccga ccaccccgac accggcaacg ggatcggcct caccggacgg
1936501 ccaccacggg caatccctga ccccgcgccg cgcagctcgc acggcccggc caaggtcatc
1936561 gcgatgtgca accagaaggg tggcgtcggg aagacgacgt cgacgattaa cctgggtgcc
1936621 gcgctcggtg agtatggccg gcgggtgctg ctggtggata tggatccgca aggagcgctg
1936681 tccgcgggcc tgggcgtgcc gcactacgag ctggacaaga ccatccacaa cgtgctggtg
1936741 gagccccggg tgtcgatcga cgacgtgctg atccactccc gggtgaaaaa catggatctg
1936801 gtccccagca atatcgatct gtccgcggcg gagatccaac tggtcaacga ggtgggtcgc
1936861 gagcagacgt tggcccgggc gctgtacccg gtgctggacc gctacgacta tgtgctgatc
1936921 gactgccagc cgtcgctggg cctgctcacc gtcaacgggc tggcctgcac ggacggcgtg
1936981 ataattccga ccgagtgcga gttcttctcg ctgcgcggcc tggcattgct caccgacacc
1937041 gtcgataagg tgcgcgaccg gcttaatccg aagctggata tcagcggaat cctgatcacc
1937101 cgctacgatc cgcggaccgt caactcgcga gaggtcatgg cccgtgtcgt ggaacggttc
1937161 ggtgacttag tgtttgacac cgtgatcacc cgcacggttc gtttcccgga gaccagcgtc
1937221 gcaggcgaac ccattaccac ctgggcgccg aagtcggcgg gtgccctggc ctaccgtgcg
1937281 ctggctcgcg agttgatcga ccgatttggc atgtgaacgg ccttcagaac agcctggcga
1937341 acggtgggac ggcacccgag aacggctact cggctggttt tcgggtccgg ctgaccaact
1937401 tcgagggccc gttcgacctg ctgctgcagc tgatctttgc gcaccaactc gacgtcaccg
1937461 aagtggcgtt gcaccaggtc accgacgact tcatcgccta caccaaagcg atcggcgctc
1937521 ggctggaact agaggagacc acagcgttcc tggtgatcgc cgcaaccttg ctcgatctca
1937581 aagcagcccg gctcctgcca gccggacagg tcgacgacga ggaagacctc gcgcttctgg
1937641 aggtacgcga cctgctgttt gcccggctgc tgcaataccg ggcgtttaag cacgtcgcag
1937701 agatgttcgc cgaactggag gccaccgcgc tgcgcagcta tccacgggcg gtgtcgttgg
1937761 aggacgggtt cgtcggtctg cttcccgagg taatgctcgg cgttgacgct caccggttcg
1937821 ccgaaatcgc tgcgatcgca ttaaccccgc ggccagcccc gacggtggcc accgagcacc
1937881 tgcacgagtt gatggtctcg gttcccgagc aggccgaaca cttgctggcg atgctgaaag
1937941 cgcggggcag cggccagtgg gcgtcatttt cggagctggt cgccgactgc acggcgccca
1938001 tcgagatcgt ggggcgcttc ctggcgctgc tcgaactgta tcggacccgg gcggtagcat
1938061 tcgagcagtc agagccgctt ggcgcgctcc aggtttcgtg gaccggtgac gatgcagagc
1938121 gcagcgatga gaaggagcgg cgcttgtgac cgaacatatg cccgaacacg atccgagcta
1938181 tggcatcccg gatatcgctg agcccgcgga gctggatgcc gacgagctta agcgtgtgct
1938241 agaggcgctg ctgttggtga tcgacacccc agtgacagcc gacgcgttgg ccgcggccac
1938301 cgaacagccg gtctaccggg ttgcggcaaa gctacagttg atggccgacg agctcaccgg
1938361 gcgtgacagc ggcatcgacc tgcgccacac gagcgagggt tggcggatgt acacccgcgc
1938421 ccgattcgcg ccctatgtcg agaagctgtt gctggacggc gcgcgaacca agctcacccg
1938481 ggccgcgctg gagaccctgg ccgtggtggc ctaccgccag ccggtcacac gagcgcgggt
1938541 tagtgcggtg cgcggggtca acgtggacgc cgtgatgcgt acgctgttgg cccgcggcct
1938601 gatcaccgag gttggtaccg acgccgatac cggcgcggtg acgttcgcca ccaccgagct
1938661 cttcctggag cgcttgggat tgacgtcgct gtcggagctg cccgatatcg caccgctgct
1938721 tcccgacgtc gacacaattg acgacctgag cgaatccctg gacagtgagc cacgtttcat
1938781 caaactcacc ggtgagctgg cgtccgagca gacgctgtcg ttcgacgtgg accgtgattg
1938841 atggccgagc cggaagagtc ccgggagccc cggggcatcc gcctgcagaa agtgttgtct
1938901 caggctggaa tcgcgtcgag gcgagccgcc gagaagatga tcgtcgacgg ccgcgtcgaa
1938961 gtggacgggc acgtggtgac cgagttgggt actcgggtcg accctcaggt cgcggtggtc
1939021 cgtgtcgacg gggccagggt ggtgctcgac gactcgctgg tgtacttggc gctgaataag
1939081 ccgcgcggca tgcactcgac catgtccgac gatcgcggcc gcccgtgcat cggcgacttg
1939141 atcgaacgaa aggtccgggg caccaagaag ctttttcatg tcggacgcct agacgcggac
1939201 accgagggac tgatgctgct gaccaatgac ggcgagttgg cgcaccggtt gatgcatccc
1939261 tcccatgagg tgcccaagac gtatctggcg acggtgacgg ggtcggtgcc gcgtgggctg
1939321 ggccgaacgc tgcgagcggg aatcgaattg gacgacggac cggcgttcgt cgacgatttc
1939381 gcggtagtgg atgcgatccc cggcaagacg ttggtgcggg taacgctgca tgagggacgc
1939441 aatcgcattg tgcgccgact gctggcggcc gccggcttcc cggtggaggc attggtgcgt
1939501 accgatatcg gcgcggtgtc actgggaaag caacgcccgg gcagcgttcg ggccttgcgg
1939561 tcgaacgaga tcgggcaact gtaccaagcg gtgggcctgt gagtcgccta agcgcagcgg
1939621 tagtcgcgat cgacgggccg gccggcaccg gaaaatcctc ggtgtcaagg cgattagcgc
1939681 gcgagctggg cgcacgcttt ctggacaccg gggcaatgta tcggatcgtg acgttggcgg
1939741 tgctgcgtgc cggtgctgat ccgtccgata tcgctgccgt cgagacgatt gcgtcgacgg
1939801 tgcagatgtc gttaggctac gatcccgacg gagacagctg ttaccttgcc ggagaagacg
1939861 tttcggttga gatacgcggt gacgcggtca cccgtgcggt ctccgcggtg tcgtcggtgc
1939921 cggccgtacg cacccggctg gtcgagctgc agcgaacaat ggctgagggc ccgggcagca
1939981 tcgtcgtgga gggccgcgac atcggaaccg tggtgtttcc ggatgcgccg gtgaaaatct
1940041 tcttgaccgc ctcggccgaa acgcgggccc ggcggcgcaa cgcccaaaac gtcgcggcgg
1940101 gtttggccga cgactatgac ggggtattgg ccgatgtgcg ccggcgcgac cacctcgatt
1940161 ccacccgggc ggtgtcaccg ctgcaagccg ccggtgatgc cgtcatcgtg gacaccagcg
1940221 atatgaccga ggccgaggtg gtcgcccatc tgttggagct ggtcacgcgg cgaagtgagg
1940281 cagtgcggtg acccaggacg gcacgtgggt ggacgaaagc gattggcaac tagacgattc
1940341 ggagatcgcg gagtccggag cggcgcctgt ggtggcggta gtcggccggc ccaatgtcgg
1940401 caagtccacc ctggtcaacc ggatcctggg ccgccgcgag gcggtggtgc aggatattcc
1940461 cggcgtgacg cgtgaccggg tctgctacga cgcgctgtgg accggacgcc ggttcgtcgt
1940521 acaggacacc ggcggatggg agcccaatgc caagggcctg cagcggttgg tggccgagca
1940581 ggcctcggtg gccatgcgca ccgcggatgc ggtgatcctg gtggtcgacg ccggtgtcgg
1940641 tgccaccgcc gccgacgagg ccgcggcccg tatcctgttg cgatccggca agccggtgtt
1940701 cttggccgcc aacaaggtcg acagcgaaaa aggcgaatcc gacgccgcgg cgttgtggtc
1940761 gctgggcctg ggtgagccgc atgcgatcag cgcgatgcac ggtcgggggg tggccgacct
1940821 gctcgacggg gtgctcgccg cgctgcccga ggtgggggag tccgcgtcgg cgagcggcgg
1940881 tcctcgccgg gtggcgctgg tcggtaagcc gaacgtcggc aagagctccc tgctgaacaa
1940941 actcgcgggt gatcagcgat cggtggtcca tgaggcggcg ggcaccaccg tcgacccggt
1941001 ggattcgctg atcgagttgg gcggtgacgt ctggcggttc gtcgacaccg cgggattgcg
1941061 gcgcaaggtc ggccaggcca gtgggcatga gttctacgcc tcggtgcgca cgcacgccgc
1941121 catcgactcc gccgaagtgg ccatcgtcct gatcgacgcg tcgcagccgc tcaccgaaca
1941181 ggacttgcga gtgatatcga tggtcatcga ggccggacgg gcgctagtcc tggcctacaa
1941241 caagtgggac ctggtcgacg aggaccggcg cgagctgctt cagcgcgaga tcgaccgaga
1941301 gctggtgcag gtgcgctggg cgcaacgggt caacatctcc gccaagacgg gccgggcggt
1941361 gcacaagctg gtgccggcca tggaggatgc gctggcgtca tgggacacca ggatcgcgac
1941421 cggcccgctg aacacctggc tcacagaggt gacggcggcc acaccgccgc cggtgcgcgg
1941481 cggcaagcag ccacgcatct tgttcgcgac ccaggccacc gcgcggccac cgacgttcgt
1941541 gttgttcacc acgggttttt tggaggccgg ctatcggcgg ttcttggagc ggcggctgcg
1941601 tgagacgttc gggtttgacg gcagcccgat ccgggtcaac gtgcgggtgc gagagaagcg
1941661 ggccggcaag cgccgctgag cgcacctcga acgtgtgacc cgggtaaccg gggatggaca
1941721 gcgaggccgg ttctgctgtc ccataatgcg gctatgttca gctgcattac gggatttagg
1941781 tgttgacacc cgagcgctcg gcgcttacgc tttctcgtat aacgggtgat aagtaccgta
1941841 ttgcgggagt aggtggagga aatggcgctg gctcagcagg tgccgaacct gggtctggcg
1941901 cgcttcagcg tgcaggacaa gtcgatcctg atcaccggcg cgaccggttc gttgggccga
1941961 gttgccgccc gggcgctggc cgacgcggga gcgcggctga cactggccgg cggcaactcg
1942021 gccggtctgg ccgagctggt caacggcgcc ggcatcgacg acgccgccgt cgtgacctgc
1942081 cggccggaca gcctggccga tgcccagcag atggtcgagg cggcactggg ccgatatggc
1942141 cgtttggacg gagtgttggt ggcctcgggc agcaaccatg tggcgcccat taccgagatg
1942201 gccgtcgagg acttcgacgc tgtgatggac gcgaacgtgc ggggtgcctg gctggtgtgt
1942261 cgggcggccg gacgggtgct gctcgagcag ggtcagggcg gcagcgtggt gctggtgtcg
1942321 tccgttcgcg gcgggttggg caatgccgcc ggttacagcg cgtactgccc gtcgaaggcg
1942381 ggcaccgatc tgttggccaa gacattggcg gccgaatggg gcggtcacgg cattcgggtg
1942441 aacgcgctgg cgccgacggt gtttcggtcc gcggtgaccg agtggatgtt caccgacgat
1942501 ccgaagggcc gggccacccg ggaggcgatg ctcgcccgga tcccgttgcg ccgcttcgcc
1942561 gaaccggaag acttcgtcgg cgccctgatc tatctgctca gcgacgcctc gagcttctac
1942621 accggccagg tgatgtatct ggacggcggg tacaccgcat gctgacctcg cacgggttct
1942681 cccgtgccgc cgtcgtgggt gccgggctga tgggccggcg catcgccggc gtgctggcct
1942741 cggcgggcct ggatgtcgcc atcaccgaca ccaacgctga gattctccac gccgcagcgg
1942801 tggaggccgc ccgggtagcc ggtgctggcc gtggctcggt ggccgcggca gccgacctag
1942861 ccgcggcgat accagacgcc gacctggtga ttgaggccgt cgtcgaaaac ctggccgtca
1942921 agcaggaact cttcgaacgg ctggcgacac tcgcgcccga cgcggtgctg gccaccaaca
1942981 cctcggtgct gccgatcggc gctgtcaccg aacgggtcga ggacggcagc cgagtgatcg
1943041 ggacacactt ttggaacccg ccggatctta tcccggtggt cgaggtggtg cccagcgcgc
1943101 gcaccgcccc agatacggcg gatcgcgtcg tggcgctgct gacccaagtc ggcaagctgc
1943161 cggtgcgggt cgggcgcgac gtgccgggtt tcatcggcaa ccggctgcag cacgcgctgt
1943221 ggcgcgaggc gatcgcgctg gtcgccgagg gtgtctgcga cccgaagacg gtagatctcg
1943281 tggtacgcaa caccattggg ctgcgactgg ccaccttggg gccgctggaa aacgccgact
1943341 acatcgggtt ggacctcacc ctggccatcc acgacgcggt gatcccgagc ctcaaccacg
1943401 acccgcaccc cagcccgctg ctgcgggaac tggtcgccgc cgggcaactc ggggcgcgta
1943461 ccggtcacgg ctttctggac tggcccgcag gagcccgcga ggccaccacc gcccgacttg
1943521 cccagcacat cgccgcgcaa ctccaagcca acgaaaaagg aagggggaca tagccatgac
1943581 gttcgcctgg cccctcggtg ccgccgaatc gacgttggag ttctacgacc tgtcccaccc
1943641 ctggggacac ggcgcgccgg cctggccgta cttcgaggac gtgcagatcg aacgactcca
1943701 cggcatggcc aagagtcgtg tgctgaccca aaagatcacc accgtcatgc attccggcac
1943761 ccacatcgac gcgccggcgc acgtggtgga aggaacaccg tttctggacg agatcccgct
1943821 gagcgccttc ttcggcaccg gcgtcgtcgt ctcgatcccg aagggcaaat gggggatggt
1943881 caccgccgag gatctgcaaa acgctacccc cgacatccgg cccggtgaca tcgtcgtcgt
1943941 caacaccggc tggcaccaca aatacgccga cagcgccgag tactacgcct attccccggg
1944001 cttcgacaag aaagcgggcg agtggtttgc ggccaaaggc gtcaaggcgg tcggcaccga
1944061 cacccaggcc ctggaccatc cgctggccac ggccatcgcc ccgcacagtc ccgcggaggc
1944121 acagggcggc ctattgccgt gggcggtacg cgaatacgag gcgcagaccg gccgcaaggt
1944181 gctcgacgac ttcccggact gggaaccgtg ccatcgggcg atcctgtcgc agggcatcta
1944241 cggctttgaa aacgtcggcg gtgacctgga caaggtcacc ggcaagcgcg tcactttcgc
1944301 ggcgttcccg tggcgctggg tgggtggcga cggctgcatc gtgcggctgg tggcgatcgt
1944361 cgaccccacc gggagctatc gcatcgagac cggaaaggcg gtctgatgaa actgacacga
1944421 gcgtcgcagg cccccaggta tgtggcgccg gcgcatcacg aggtgtccac catgcggttg
1944481 cagggccgcg aggcggggcg caccgagcga ttctgggtgg ggctgtcggt ctatcggccc
1944541 ggcgggacgg ccgagccggc gccgacccgg gaggagaccg tctacgtcgt gctcgacggc
1944601 gagctggtgg tcaccgtcga cggcgccgaa accgtgttgg gctggctcga cagcgtgcac
1944661 ctcgccaaag gcgaactgcg atcgatacac aaccgcacgg atcgtcaggc gctgctgctg
1944721 gtgaccgtcg cgcacccggt tgccgaggtg gcgtgatgag ctgcaccggc gacgatgcag
1944781 agcgaagcga tgctgaggag cggtgcgaat gagcatcgtc atcaccgtcg cacccaccgg
1944841 ccccatcgcc accaaggccg acaacccggc gttgccgacg agccccgagg aaatcgcgac
1944901 agccgtcgag caggcctacc atgccggtgc cgcggtggcc cacatccacc tgcgcgacga
1944961 aaacgaaagg cccacagcgg atccgaacat cgcgcgccgg gccatggacc tcatcggcga
1945021 gcggtgtccg atcctgatcc agctgtccac cggggtcggc ttgacggtgc ccttcgagca
1945081 gcgcgagcaa ctggtcgagt tgcgcccgcg gatggccacg ctgaatccgt gctcgatgag
1945141 cttcggcgcg ggcgaattcc gcaacccgcc gcaagcggtt cgtcggttgg cggcacgcat
1945201 gcgggaactg gacatcaaac cggaactgga aatctatgac accgggcatt tggaggcgtg
1945261 cctgcgactg tgggcggaag acctgctggc cgaacccttg cagttcagca tcgtgctcgg
1945321 ggttcggggc ggaatggccg ccaccgccga taatctgctc acgatggtgc gccggctgcc
1945381 ccccggggcg atctggcaag tcatcgcgat cggtaaggcc aacatggaac tgaccgccat
1945441 gggcctggcg ctgggcggca acgcccgagt cggcttggag gacaccttgt acctgcgcaa
1945501 gggcgagctg gcgccgagca atctggcgct ggtatcgcgc acgatacgtc tcgccgaagc
1945561 cttggacctg ccgatcgcct cggtcgaaga agccgaggcg gcgctgcagc tgcccggcac
1945621 gtcctgagag gagctcgctt gtgtccgccg aagagcagga cacccgcagt ggtggcatcc
1945681 aggtgatcgc gcgggcggcc gaactgctgc gggtgctgca ggcgcacccc ggcggtctca
1945741 gccaggccga gatcggcgag cgggtgggca tggcccgctc gaccgtgagc cggatcctca
1945801 acgcgctgga ggacgagggg ctggtggcct cgcgcggggc ccggggaccc tatcggctgg
1945861 gcccggagat cacgcggatg gccaccacgg tacggctggg tgtcgtcacg gagatgcacc
1945921 cgttcttgac ggagttgtcg cgcgagctgg acgagacggt ggacttgtcg atcctggacg
1945981 gggatcgggc ggacgtcgtg gaccaggtcg tgccgccgca gcggctgcgg gccgtgagcg
1946041 cggtggggga gtcgtttccg ctgtactgct gcgccaacgg caaggcgctg ctggccgcgt
1946101 tgccgcctga gcggcaagcc cgcgcgctgc cgagtcgact ggcgccgctg acggcgaaca
1946161 ccatcaccga ccgcgcggcg ttgcgggacg agctcaatcg catccgggtg gacggtgtcg
1946221 cctacgaccg tgaggagcag accgaaggca tctgcgcggt gggcgcggtg ctacgggggg
1946281 tgtcggttga gttggtggcg gtgagtgtgc cggtgcccgc gcagcggttc tacggccgtg
1946341 aagccgagtt ggccggtgct ctgctggcct gggtttcgaa ggtagacgcg tggttcaacg
1946401 gcactgagga tcgcaaatga cagaagcgtt gtgcgacaag ctcgttgggg cctgggacct
1946461 ggtgtcctac gtggagcggg ccgcggcttt ggcgttggga tacctggcct acggcggacg
1946521 gtagttcgtc gacaaggcgt agggcgtggc cgggtttgca ggccggctgc ggtaggcttt
1946581 cgacctgccg ccggtggtgt cgccggtggc accgggctgt ggcgcagttt ggtagcgcac
1946641 ttgactgggg gtcaagtggt cgcaggttca aatcctgtca gcccgactta cgtttccgca
1946701 ggtagaccgc cctgctggcg gtcctcggct gccgctgagg cagtaccgcc aaggggtatg
1946761 tacagcaacc ggtacagcaa cccggtcaaa tccccagagc accgctgaga ccttccactg
1946821 cggctcgcgc cgcttcgtcg ctggtatgac cgcgccaccg tgctggacac cgcctaccga
1946881 gaccacctcg agcggttcgt tcgcaaacca cccgagccac ccgcgctacc ggccttcagc
1946941 gcgatcaacc caccaccaaa ggaggaccag ccgactcaat gaatccccga aaatcgtgtc
1947001 tcagaaatgt tgacaggttc cgcggtagat caggcgacaa gctcgatctc cgcattatgg
1947061 ccatgggatt gggcaagtcg cccgtcgcaa gtgataagcg gtacgccgag gccctcggcg
1947121 agggcgacgt aggctccatc ggccacggta tgagtggacc gaagttggta ggcacgctgg
1947181 gtgaatggct ttaacggcca acgccgaacg ggcaggctaa ggaagttgac aaccacgacg
1947241 agtccttcat gatcgctgat cagctgacgc acgaccgctt gacgtatcgc cccgatcacc
1947301 tcgacatcga aatgtgcagg ggcgtgcacg gtttcgcccc gcaagcgccg ggcgaccgcc
1947361 gcacccgccg gcgtcgtgag catgagctcg acggccgccg aggcgtccaa cacgatcact
1947421 cagatcgagc ctcgtcaaca agctcggctg cgctcgcgcc gagatcccgg cgcggcagtg
1947481 ccgctagacg gtcgagaacg tcgtcgaggg ccggttcttc cgcgatctcg gcaagccgtg
1947541 ctaggaggaa atcgctcagg ctcatccgtt gcgccgctgc gcgggccttc agctcgtgga
1947601 gaagctcgtc gggaacgttg cggatctgaa ccatggcgga catgttgtaa gcatatcgga
1947661 catgtgaaac acatgtccgg ttgccggtgt gaccggctgg ggcgtgtagg cgtcaaccca
1947721 cgccgtgcac gcggccatgg gcgggtgcag acttttgcca tgcaaccatg tgagctcacc
1947781 gccgtcgcgc tgaccgcaac gcccccgccc gcgcctccgt ccctgcgccg ggcaccggcg
1947841 tcgacgtcac cgcggctggc gtgatcgtgc ccgcccgcga gcctgagccc cagccgcgcc
1947901 gcgtgctgaa cggcctttcg gacgtacgcg cgttctttca caacaacacc gtgccgctgt
1947961 acttcatctc gccgacgccg ttcaacctgc tgggcatcta tcgctggatc cgaaacttct
1948021 tctacctgac ctactacgac tctttcgagg gcgaacattc gcgcgtgttc gtgccccggc
1948081 ggcgcgaccg cagggatttc gacggcatgg gggatgtgtg caaccacctg ctgcgtgatc
1948141 ccgagacact cgagttcatc aagaacaggg gtcccggtgg caaggcctgt tttgtgatgc
1948201 tggacgaaga gacccaggcg cttgcgcgcc aggcggggct cgaggtcatg caccccccgg
1948261 cggagctgcg tcatcgcctg gaatccaaga tcgtcatgac gcgcctggcc gacgaggcgg
1948321 gcgtacccag cgtgccgcac gtgatcgggc gggtgagctc ctacgacgaa ttgtcggcgc
1948381 tcgcgcacgg cgcagggctg ggagacgacc tcgtcgtcga ggccgcctat ggcaacgccg
1948441 gcagcgcaac gttctttgtg cgcggattgc gcgactggga ccagtgcgcc ggtggcatag
1948501 tggggcagcc ggaaatcaag gtcatgaagc gcatccgcaa tgtcgaggtg tgcatcgagg
1948561 ccaccgtgac ccgccacggc accgtgatcg gcccggcgat gacgagcctg gtcggttacc
1948621 cggagctgac tccgtaccgg ggcgcctggt gcggcaacga tgtttggcgt ggggcgctac
1948681 cacccgcaca gacccgcgcc gcgcgagaga tggtggcaaa gctgggcgac gtcttgagcc
1948741 gcgagggcta ccgcggctac ttcgaggtgg acctgttgca cgacctggac gccgacgagc
1948801 tctacctcgg cgaggtgaac ccgcgcctct ccggtgcaag cccgatgacg aacctgacca
1948861 ccgaggccta cgccgacatg ccactgttcc tcttccacct gctcgagtac atggacgtgg
1948921 actacgagct ggacatcgag gcgatcaact cgcgctggga gcggggctac ggcgaggacg
1948981 aggtctgggg tcagctgatc atgtcggaga cctcgccgga cctcgagctc ttcaccgcga
1949041 ccccacgcac cgggatgtgg cgcctgaacc acgacgggcg cgtctccttt gcccgccagg
1949101 gcaacgactg ggccacgatg ctcgacgagt ccgaggcctt ctacatgcgg gtcgccgcac
1949161 cgggcgacct acgctgcgag ggcgcccaac tcggtgtgtt ggtcacccgc gggcacctgc
1949221 agaccgacga ctaccagctc accgagcgcg gccggcgctg gatcgacggc ctcaaggcgc
1949281 agttcgcctc gacgccgctg acgcccgccg ccccgatcgt ctcgcggctc gtcgcacggg
1949341 cgtgagcggc ggcgtcccgg ccggtctcgc actggacaac tggctgtcgt cgccgtattc
1949401 gcattgggca ttccagcacg tcgaagactt catgccgacc acggtcatcg cgcgcggcac
1949461 cgagccggtc gtgacgttgc ccgcggacaa tgcgccgatc gccgacatcg gcttgaccag
1949521 cacggacggg atcgccacca ccgtgggcgc ggtgatggcc gccaccgcta ccgacgggtg
1949581 ggcggtcgcg catcgcggtg cgctggtggc cgagcagtac ctcgacggcc tgggaccccg
1949641 gacccgccac ctgctgttct cggtgagcaa gtcgctggtg gcggctgtgg tcggcgcgct
1949701 gcacggggcc ggggcgatcg agcttgacgc gccggtcacg gcgtacgtgc ccgccttggc
1949761 ggactgcggc tacgccggtg cgacggtgcg ccacctgctg gacatgcgat cgggtgtcgc
1949821 cttctcggag aactacgacg acccggccgc cgagattcac gtgcgcgagc aggtgatcgg
1949881 gtgggcgccc aagcgcggtc cggacctgcc cgccacgctg cgcgactacc tgctgacctt
1949941 gcggcggaag tcggcgcacg gcggcccgtt cgaatatcgc tcgtgtgaaa ccgacgtcct
1950001 cggctggatc tgcgaggccg cggccggaca gccgatgccc gaactgatgt cggaactact
1950061 gtggagccgc atcggggccc agtgcgatgc caccatcgcc ctagacgtag ccggcgcggc
1950121 gggcaccgga atattcgacg gcggcatcag cgcctgtctg accgacatga tccggttcgg
1950181 gtcgctgtac ctgcgcgacg gtgtctcgtt ggccggccag caagtggtgc ccgcggcctg
1950241 gatcgccgac accttcgacg gcggccccga ctcgcgtcag gcgttcgccg ccagccccga
1950301 cgacaacccg atgcccggcg ggatgtaccg caaccaagtg tggtttccct acccgggcag
1950361 caatgtcgcg ttgtgcgtgg gcatgtgcgg ccagctgatc tacgtcaacc gcgccgcgga
1950421 ggtggtcgcc gccaagctgt ccacccagcc gcactcccat gagccgcaca tgttagacac
1950481 cctgcgcgca ttcgatgcgg tggcacacga attgtcagga atcagatcga gttcgaccaa
1950541 cgacccgcag cggccttccc cgccagccca ggaggccagt ccggggtaac ggcttgtgcc
1950601 cacgtaaccg agttccaggg cgatgggctt attagcggaa atatgactcg tcccaggtat
1950661 ccatacgacg cttgcgtacc tcggcgagct tgtggtcaag cgccgcctgc tcattttcga
1950721 tggcacgacc ggcgtttctc acggcgttgt agacggcatc gtccagtttg catagatcct
1950781 ttgcggacac gtcggtcgat acgaaaaccg agaaccgaat acggtcgtcg agcagcgaaa
1950841 tgtcgatctt tggtgatggt ttgagttggc gctggaagtg tttggctagt gcttggatcc
1950901 aatactttgg ccaatgcggc accggtctca gatcgtagac gatgatggct tgctcgccgt
1950961 tgtagacgcc gatgggcgct tccgctcggc tgaagcatgg tcgccgcagg ttccgcaggt
1951021 cctggagttc gttctcttca ttacccacca tgagcctccg gcatctggtc tacggacacc
1951081 acggcttgcc gcatggctgg ggcgaaggga ctccaagcca tccaggatgg gaacgcgcgc
1951141 cgcatcgccg gcaggccgtc cagttcgatg cgctcggcgg agatctcggc ggccagtgtg
1951201 ctgcggccgc tgtagacccg atacagatct cgaggatggc cgcgcaccgt gaggtcgaca
1951261 ggtaggcatg gatcgtgcag gcacaccgag atgtccccag gttccaacac gagccaggcc
1951321 cacagtggcc gctcgccgtg gtagcggaac tccaccacca cccgccggcc gggaagggcc
1951381 tcggtgttga cgcgccggga gatccacaac gtgagtagtt cggggtcgca ttcggcggga
1951441 gtggggtcgg ccatcaacca acgggagacc cagtccccca gggtctgcag cacggggcgt
1951501 agctcctcgc cggccaccgt gaaccgatag cccccgcccg tgtgttcggg gaccgcttcg
1951561 atgatgcggt cgtgctgaag tcggcgtagc cgctgggcca gcaccgagcg ggagatgccg
1951621 ggcaggcccc gctcgatttc ggtgaaccgc agcgggccga agagcagctc ccgcacgatt
1951681 agcagcgtcc agcggtcccc cagcagctcc gccgcccgcg ctaccgggca gtactggccg
1951741 tacggctgca cgacaccagg ctagtcgcca tccctggctg cgtggttcgg aattcgaact
1951801 tcccgcaccc cctgtgggag gcgtaacgct tggtgctgga ggtgagaggc gatgaccgcg
1951861 acgctgacca agacgctggg ttccctcgac gatttcaggg gaacgctttg tgtccccggt
1951921 gatccggact accccagggt gcgggccatc tggaacgggc aggtggcccg cgaaccggcc
1951981 ttgatcgcca cgtgccacga cgcgtgcgat gtccgaacgg tgctgcggcg cgcggtggac
1952041 gccgggatgg tgaccgcggt acgtggcggc gggcacaacg tggccggcac cgcgctgtgc
1952101 gacggcggcg tggtgatcga cctctcggcg atgcgggccg tctcgctgga tccagcgact
1952161 gggcgggtac gggtgcaggg tggtgccacg ctcgccgatt tggaccacgc cacggtcccg
1952221 ttcgcccggg tggcccccgc cgggatcgtc accaccaccg gtgtcggcgg gctgacgttg
1952281 ggcggcgggg tgggttggac gactcgacgt ttcggactga gctgcgacaa cctggtcgcg
1952341 gtgcggctag tcaccgccgc cggcgactac ctaagcgtcg acgacgagcg cgacccggag
1952401 ctgatgtggg gcctgcgggg cgggggcggc aatttcggca ttgtcactga attcgaattc
1952461 gccacccatc cgttcggtcc ggtcgccgtg gccggcttcg tcgtctaccg gctggatgac
1952521 gggcccgcgg tgcttcgcgg ctaccggcag ttcgccgctg cggcacccga ggaggtgacc
1952581 acgatcgtgg tcttgcgcca cgccccgccg gcaccgtgga ttcccgttga ccagcgcggc
1952641 aagccggtgg tcatgatcgg cgccgtccac accgggagca tccagaccgg gatcgaagcg
1952701 ctgcgaccgg tcaagtccct cgccagaccc gtcgccgaca ccgtgtggcc gaccccgttc
1952761 ctggcccacc aggcggtgct ggacgcctcc aacccggccg gtcaccgcta ctactggaaa
1952821 tccgaccact tggccgagct gaacgacgag gccatcgact tgctagttga gcagacggcg
1952881 cagctgtcct cgccggacag cctcatcgga atcttccagc tcggcggcgc cgccgctcgc
1952941 ggcggtgagc gttcctgctt cccgagccgg cacgcgcgat tcatggtcaa ctacgccacc
1953001 cattggaccg aggcccgcga ggacgacctt caccgccaat ggacccgcga cgcgatcgag
1953061 gcgctggccc cgtacgggct gggcaccgcg tatgtgaact tcaccgccga cgacgcaccg
1953121 atgcacgtcg aaacacttta cagcacaacg gagttcagtc gtttggtgac cctcaagaac
1953181 cgactcgacc cggacaacgt gttccgcaat aaccacaaca tccgcccctc ggcatgaggg
1953241 ggcccaagtt gaccgtagga aggacgatca tggacctcta ttcaaacctc gtcgaagccg
1953301 aacaacgcct ggtcgcgctg gtttcgtcga tagaagccga cagctactcc tcgccgacgc
1953361 cgtgcgaccg ctgggacgtg cgggcgctgc tcagccacgc gctggcctcg atcgacgcct
1953421 tcgcggcggc cgtcgacgga gcacccggac cggacatggc gcaggtgttc agcggtgccg
1953481 acatcgtcgg ggacgacccc ctcggtgcga cgcagcggat cacccggcgg tcgcaggcgg
1953541 cctggtcgac cgtgcgcgat ctgaacgcgg agctgtcgac cttcatcggc gtgatgccgg
1953601 cggggcaggc tcttgcgatc atcaccttct ccaccgtcgt ccacggttgg gacctagcgg
1953661 tggccacggg ccaggccggc gaactcccgg agcacctggc cgaagcggcc caacaggtgg
1953721 cggccgaact ggttcccgtc ctgcgtccgc ggggcctgtt cgcacacgac gtcgacctag
1953781 cgggggaagc cacgcccact cagcggctcg tcgcccttac cggacggaaa ccgcggtgag
1953841 ctgcgtttgg ttgtcgcgtt cgatcattct ggcggcgtag ggctcatgga tccgacgtag
1953901 taggtttccc gcccggttgg gtatccgccg ccgtcggtgg cgatatggac gtggtcgtag
1953961 tggttgaggg tttctgagcc gtagtccgcc gtccagctcg gcgcgccgat gcctgggtag
1954021 tagccctgcc gccagatcac atggagcact ccccatcgtt tcgcattcgc caaggcaagt
1954081 ccggcgactt ggttgccgag ctggataccc tcgtcgctgt gatggttcgg gatcatcacg
1954141 tcgatcgcta acccgttggg atgccacttc aagggatcct gcctatagcc aaagatgttg
1954201 gtgatctgag gaaatagcac agagacggca cgggctaccc agatcgtctt gacctgcaac
1954261 ccctcttccg acgcaacgcc agcaggtagc gcgaactgga attgctgggc agcgacaggc
1954321 gcgcttgccg ccaacaagtc cgcttccgtg ggactggcga tgcgcggtgc gttggccggc
1954381 gcagagtcgg ggcctgtcgg gattgccgcc ggggtctcgc ggcagcacgt atgctctgcg
1954441 ccttgggcat agaggatggc ggcagagacg acgagcgagg ccgcgattgc caaccagcgg
1954501 ccccggccgt tggccaacac gcctttgctc acgaacagca ctttagtgtg tcgtgtgcga
1954561 cgcgtgtggc aacctttgct atcgattggt tgcagacccg cgttgtgcgc accgggcaag
1954621 ccgttcacgc tcatcgccaa cccgctgccg tcggcggtga aatggaagag tggtcggtca
1954681 ggcagccgct gatgaagatg gtgtcgtcgt ctgcagcgcg cacatcgaga ccgctgcgcc
1954741 ggaacagttc tgccagcgac acgccttcgg gttgccagcc cttggcggcg aggtagtcga
1954801 ggacgtggtt gcgtgggccg gtgtagacca acgaagccaa gtcgacgtcc acgccatgac
1954861 agcggaacgg gttggatatg gtccgcgctc gttcggcgct gaaatccgct ataccggtaa
1954921 caaattcggt ggctaccatg ctcccgggcg cgctgagtgc ggtgatgttg tcgaacagcc
1954981 tgtcttgagt ttgcggctta agatatatca gtaacccctc ggccagccac gccgtcggtg
1955041 ctgccgagtc aaacccggcg gcttgtaatg ccgtcggcca gtctgcgcgc aagtcgatgg
1955101 gcacggcgcg ccggatggcg gagggttcgg cgcccaggtc ggctaaggtt gtcgtcttga
1955161 actccatcac ttttggttgg tcgatctcgt ataccaccgt cctggtcggc cacggcagcc
1955221 ggtaggcccg ggagtccaac ccggacgcga ggatagcgac ttgccgaatc cccccagcgg
1955281 tggcgttaag gagatagtcg tcaaagtatt tggtgcggac cgcgtttccg tacaccattg
1955341 cctgcgccac ggccggtgaa acgtccgcga tcgtcgacat gtcgagttca ccgtccatca
1955401 tcttggtgaa caaatccagc cccaccgcac ggaccagggg ttcggcgaac ggatcgttga
1955461 tcaaaccgcg cggatccttg gtggccagcg cacgcccgac cgcgacaatg gtcgcggtga
1955521 cgccgacgct agacgtcaga tcccagttgt cgtcgtcggt gcgggccacc agcccaccct
1955581 agtctgattg cccggttcct cctcgcgccg caaacggcgc gcatcgtcac cgggcgtcgt
1955641 ctgattgccc ggttcctcct cgcgccgcaa accaagccgg ctggtgctgt gctattggcg
1955701 tcggaacaga cggccgtgct ggctacagaa ccaggcgatg ttgccgtccg gcccgcgcac
1955761 gaagttggag cgactgccgg tgggcttgtt gtcgggtcca aggtcgagcc catagtcggg
1955821 ccgatagaag gcgaggccca gattggcgct gttttggcca tccgggttgg catcgtcggt
1955881 gctcatgctt ccagcaagct ggccgtccct ggcccggaag tcgatgaccg ttgtctcgag
1955941 gtcgccattt tgggcgactt gcttggcgat gtaccggccc tcgtagggcg ccaggtcgac
1956001 ggcaccaagg cgttgcggcg tggccggaag attgctgagc ccggcgaatc tctgcaatgc
1956061 ccagtcggat gcgaaaaggt cgttgatcat atgaaatccg ccatcagagt tagtgagcac
1956121 ggtcatggcg aagtttcgat cgggcaccat gacgaaccca gagcgctgcc ccttccaggt
1956181 gccgccgtgc tcaacgatgg tcacattctc cgcggagggc cgcagcatcc aggtcacgcc
1956241 catcccggtc agttccaccc aaagtgttcc gcccgcccca gggttagagc gcattgcctt
1956301 cagcgattgt cggctcagaa tctgctcacc gttaggcgcc ctgccgtcgc cgaggtggaa
1956361 ctgtgcgtaa cgcagctgat ctcgcgctgt ggacatcaac ccaccggtgg ggttgcagct
1956421 gcgcgggaat gtccaaaagt cagtaacggc aatcggtttg ccgtcgacca cgctatgcga
1956481 tgcggccaca ttcagaccga ttatttggtc ggaaaagtag cgcgtgtgag caagctgcag
1956541 cgggtcaagc aacagcctct gaaccgtaga ttcgtaggtt gttccggcga caagctcgat
1956601 gatgcggccc gcaaccacaa gacctgaatt gttgtacgcg aacgcggttc ccggaggggt
1956661 gagctgcggt aggcgtgtca tcgccttgac atagagcgcc accgcgtcat cgccgcgccc
1956721 aaagtcctgc ccattgcgac catcccagcc tgcggtatgg ttgagcagtt ggcgaacggt
1956781 aaccgtagcg ctggctgatt cgtcggctac cgcgaagtcg gggatgtagc ggcgcacagg
1956841 tgaatccagg tccaccttgc ctcgctcgac cagccgcatc atcaccgtac ctgtgaaagt
1956901 ctttgtggtg gaaccgattc tgaagacagt gtcgccgtca acaggcatcg gatggtcgac
1956961 attggtgacc ccgtagcctt tgacgtattc ttgcccgccg gcccagacag caaccgcgac
1957021 gcccggaatc gcataggcct tcatgcccgc gttgattttt gcatcgagtt cgtcgaacgc
1957081 tgcaccaggg tctgcgcagt tgacagtttc aaccactgca gtggcgattt cgtgcggcag
1957141 tcgatctagc gcacgcacgt attcggtgac gaccgcgcgc ccatggcgcg tcccgcaccg
1957201 cgtgccggtc ggcgtcgcgg aactcaagat gatcggcgga cacaaggacc gcggcgaccc
1957261 ggccggtggc ggccgatctg aacagcttcg tggggggatc cgcttcgtca accaacgcgg
1957321 aaagcatggc tttggccttc cgcggtcgcg tccacatgag tgtcaatata gctggactaa
1957381 catgaacatc gcgaggccgg ttcttcgtgg taacgtgccg ggatcccaag ggactgccgg
1957441 aagcgaattt ggttgcgccg cttggggcgt cgcgagagat tcggcaatcc cctggctgga
1957501 ggatcccgtt cagccagggc gtaggcgctg cggcgtgcac ggcttggccc cacaacccgt
1957561 attgatgcca cctgaacaag aagaacccgg cattcgtcga gaatgccttt ggtcaccaat
1957621 cgcaggccga tactctgtgc cctagacacc cgcatttctt cgaaagaggt gacgatatgc
1957681 ctgcaccctc ggccgaggtt ttcgatcgct tgcgtaacct ggccgcgatc aaggacgtcg
1957741 ccgcacgtcc gaccaggacg atcgacgagg tcttcaccgg caagccgttg actacgattc
1957801 cggtcggcac ggccgcggac gtcgaagcgg cattcgccga agctcgcgcg gcgcagaccg
1957861 actgggcgaa gcgtcccgtc atcgagcgag ctgcagtcat ccgccgctat cgcgacctgg
1957921 tcatcgagaa ccgcgagttc ctcatggacc tcctgcaagc cgaggcgggc aaggcccgat
1957981 gggcggcgca agaggaaatt gtcgatctga tcgcgaacgc gaattattac gcacgagtct
1958041 gtgtggacct gctgaagccc cgtaaggcac agccgctgct gcccgggata ggcaagacca
1958101 cggtgtgcta tcaaccgaag ggcgtggtgg gggtgatctc gccgtggaac taccccatga
1958161 cgcttacggt gtcggactcg gtgcccgcgc tggtggccgg taacgcggtg gtgctcaagc
1958221 cggacagcca gacgccgtat tgtgcgctcg cgtgtgccga gctgctgtat cgggcgggtc
1958281 tgccgcgagc gctgtatgcg atcgtgcccg gtccgggctc ggtggtgggc accgccatca
1958341 ccgacaactg cgactacctg atgttcaccg gttcatcggc gaccggcagc cgcctcgccg
1958401 agcacgccgg ccgccggctt atcggtttct cggccgaact tggcggcaag aaccccatga
1958461 tcgtggcgcg gggtgccaac ctcgacaagg tcgccaaggc ggccacccgt gcctgcttct
1958521 cgaacgccgg ccagctgtgc atctccattg agcggatcta cgtcgaaaag gacatcgccg
1958581 aggagttcac ccggaagttc ggcgatgcgg tgcggaacat gaagctcggc accgcatacg
1958641 acttctcggt cgacatgggt agtttgatct ccgaagcaca gctgaaaacc gtgtccggtc
1958701 acgtggatga cgcgacggcc aagggcgcca aggtgattgc gggcggcaag gctcgacccg
1958761 acatcgggcc gctgttctac gagccgaccg tgctgaccaa cgtcgcaccc gaaatggaat
1958821 gcgcggccaa cgagacgttc gggccggtgg tctcgatcta cccggtcgcc gacgtggacg
1958881 aagccgtcga aaaggccaac gacaccgact acgggctcaa cgccagcgtc tgggccggct
1958941 ccaccgcgga gggccagagg atcgccgccc ggctgcggtc ggggacggtg aacgtcgacg
1959001 aggggtacgc gttcgcctgg ggcagcctca gcgcgccgat gggcgggatg ggcctctcgg
1959061 gggtcggccg ccggcacggt ccggagggct tgctcaagta caccgaatca cagacgatcg
1959121 cgaccgcccg cgtgttcaat ctcgatccgc ccttcggcat cccggccaca gtctggcaga
1959181 agtcactgtt acccatcgtg cgcaccgtga tgaagcttcc cggccgcagg tgacggcgcg
1959241 gcctagcgcc acttgatgcc gcacccgatc gacggtcgtt ggtcggggtt gactggccgc
1959301 ccggcgagca gggcgtcgac cgcggcccgg acgtcggcgg ccgtcaccgg tcggccattg
1959361 cccgggcggg agtcgtcgag ctgaccacgg tagacaagtc ggcgctggcc gtcgaagacg
1959421 aacgtgtcgg gtgtgcaggc cgcggagaag gcgcgggcga cgtcttgggt ttcgtcgtag
1959481 agatacggga acgtccagcc gtggcggcgg gcctcggcga ccatctgatc gggcccgtcc
1959541 tgcgggtagg tgacgacgtc gttactggag ataccgacca tcgggacgcc ttgatcggcg
1959601 aggtcccggc cgagcgtggc caatccggcg gcgacgtgtt gcacgtacgg gcagtggtta
1959661 cagatgaagg tgacgacgag ggcgggaccc gtgagctcgt cgaggctgac cgtggcgccg
1959721 gtcgccggct ggggcagtgt gaacgacggc gcgggggtgc cgagggcgag catgctggat
1959781 tcaacggcca tgccgtccag agtacggtcg cggtccagct tggcggagcc ctggttgccg
1959841 ctaccggacg gttgtcaccg ctgcgtgcag aacaggctgt cgatgtcgtg ttgccaactg
1959901 gcgttgcgaa cgcggatcag aatcgcccga gtgagcgcca gcagggcgcc cgcaaccgcg
1959961 gcgacgctca accagagtcc caaggcggcc agggccgcat ccgcaatggc acgggccggc
1960021 ggagctggtt catcgaccag ctgaccggca ctgtcgaccc aaatgccgac gcggtcaccg
1960081 gatttggttc ccggcttcgc gttgacctca ccgctgcgtt ctattccgtt cacgacccat
1960141 cgggcaggca cggtgatctt cgtgcgcggc ggcgctgacg tggcggtcgt gttgctgtcg
1960201 atcaccccct cgtgatcgat cacggtcgcg gttgcgggat ggcgggtctg ggcctggtgg
1960261 gcatagacgt ggctgcggga atcctggact gcggtgccgg ccgcggcggc gaacgggata
1960321 gtcagcagcg agaccgtgac ggccagcagc atgacgaccg cctcgagtcg atccgtccca
1960381 cgcaccagcg gattgcggct gaacacccgc agtatcgtcc ggcacggcaa gcgcagccta
1960441 aacgtgatca tggtggctcc ttcacgatcg cgggttgtgg cgatcatcgc tgtgaattgc
1960501 tcgtggctcc tagggtcgtt cggccttggg gctggggacg tcggtcacga atggctgggc
1960561 gccgtgcata tcgggtgaac cgggcgtcga acaagcgaag ttttattgtc ggataaggga
1960621 ctttcgcccc ttcccgcctg ctgtgtttgg tggcagtatt ggtgataccg gggaaacccg
1960681 gtgatctgcc cgaagtgctg ggcgattgag cgggtatgta cacccggttt gacctaccgt
1960741 cccaagacgg ggctaccgcc ttcgggcaga tcctcatcct gttactgcgg cgcaccgcgt
1960801 cagctcgttg atcgacagga agaacagcgc gccgcgatgg tcatcgctgc agccgtggtc
1960861 agcgggcagc gtagccagca cggtcgtcat gacgtggatc gcgccgtcga cggcgcaaac
1960921 tcgttgtgcc ggcttgccga aactgaccag cgcgacctga ggtgggtaga tcaccccgaa
1960981 gaccgcgtca accccctggt caccgacgtt ggtcatggtg atcgtgaggt ccgatagctc
1961041 cgagcccggg gacttcggtc cccagagccc ccgacttgga tcagtggtcg gatatcgctc
1961101 gatgacagcg atgagctcta cacaactggc cgaggccaga acacgaggtt cgcccgcgtg
1961161 ctcggaccat atctggtcgt tgtcaccgcc acggcgctag cgcacgcgtc gtcgcggacg
1961221 tcccgcttgt tacgggcgat tggtggccag gcggtcatgg tgctgatggc attgtcgggc
1961281 ggtatctcag ctacatcggc tggtttcgac gaaacgctcg aacttggtgg tcgaacgacc
1961341 gcggcgggcg gcagatgatg gcatgggtgt catcagcggc cccgatggcg tgcgatgacc
1961401 ggccgctgcg gccgatggtg gcggctaggt ggtgcagcat ggcaacgaag gtgatcgtcc
1961461 acaccgccaa cgcgacccaa ccttcgaatt cgccgatgct ttcgacgatg ggcagatggg
1961521 cggccaggcc gagacggtat gcgcccacgc cgtacatgcc gagcgggaac acgacgctcc
1961581 acaacgttgc ctcgtagcgc agcgggacac ggtggacgac atgtttccat atgctggcgg
1961641 cgaccagcgg tgggatcagc cacggtccga aggcccagaa caccaccgac gctcccgcaa
1961701 cgagtccgct ggtgacgata gccattggtg catcagccat ttcgacgatg tgggcgccgg
1961761 ccagcacggt gatagccgtg gcgcccatcg ccacccaata gggcggggtg agatccgcgg
1961821 gccgcagcgg gtagagcagc aggcgggcga cgaccaggct gccgacagcg acgtacagaa
1961881 acacgcctac tgaccaacta atcgcgtgcc gagcacgtcg gacgcagcga caaaggtgaa
1961941 catcccaaat ccccggcgcg gatcagctag gtcgtcggcg aattctttgc ggaagatgac
1962001 gattcgtgtc gtgctcaccg cgatcaagac agcataggcg gtgcaggtca cccacagcag
1962061 gacgacggaa agggcatacg tccacccgca caggcgggtg acgacagggc cgaaagtcgt
1962121 gtctcgcatc gaaatcgacg ccagcgcgga cttgttcgac gagtagacgt gtcgctaacg
1962181 tcgatctcga tgggcagtcc tgtccgctcg ccgaagacgc actcccgtca ccacccgcgc
1962241 cgccgcggcc gcgttagcac cagctcctcg cggctgcggt agatgatgta cgggcggaac
1962301 agatagccga tcggggcgct gaacgcgtgt accagccggg tgaacggcca caacgcgaac
1962361 aacgccaacc cgatcagcac atggatctgg taatacagcg gagcctcggc catcaggtcc
1962421 ccgcgcggtt gcagtaccca caccgagcgg aaccacaccg acaccgtctc gcggtagttg
1962481 tacgcctcgc cgacaacgcc ggagcccaac gccgtcgcac ccagtcccgc gacgatcgcc
1962541 gccaccagca cgaggtacat caccttgtcg ttgacggtgg tagccatgaa caccggcccg
1962601 cgggtgcgcc gccggtagat cagcagggta acgccggcca aggtggtgat gccggcgatc
1962661 gaccccagca cgacggcctg cacgtgatat gcgccctcgc tcaaaccggc ggcctgagtc
1962721 cacgactgcg ggatcacgag cccgataccg tggccgacga tgaccaccag gatgccgaaa
1962781 tgaaacatcg ggctggcgat ccgcagcagc cgcgactcgt acagctggga cgagcgggtg
1962841 gtccagccga atttgtcata gcggtagcgc caccaggagc cgaccgcgac gatcgtcatc
1962901 gtcacatacg gcacgacggt ccagaagagt tcgcccatca tgtcacccgt ccggcatacc
1962961 gcggccaccg tgtgtgcgta tggcaatgcg gcctcggtca gggcattgca cagcgcggcg
1963021 atgggcaccc ggtacccgct cagcaaccgt cgccccgcct cggggtcgac ggtcgcggcg
1963081 aattcgagca ccaccggcag gaagtccggg gtctcgccgc gcggtggtgc gacgtcggtg
1963141 ctgcggtagg tctgggcgaa ggccagcatc tcccggccgc ggttgcgggt gtcgccggcg
1963201 gtccagtagg tcaggtacag ggtggcgcgg cctcgcaggt cgaaggtgtc gacgtagcgg
1963261 gtcgccgcgg tcagcggatc ggcacggcgc agctcagaga ccgtgcgccc caacagatcc
1963321 gcggccggac cgtcgatgtg ggccagcaat tcctctgcgg tgccgagttg ccgtgagttc
1963381 gggtaggtca gcagcaccga ggcgcattgc cacaccacgt cccaccaatc tccggactcc
1963441 ggcacgtcgg tctggtcgcc gaacacctgc ggggaggcca ccggcaggtc ggcgtaccag
1963501 tcgtagaacg acgtcatcac cccgccgatt agctccacga accgcgaccc cgcggcgtgg
1963561 ctcaccatgg acatcgccgg gatgggggag aagccggcaa cccggtccgg gccgtatgtg
1963621 gagatggtgt gcacgtgggc ggcggcgatc atctcggtgg cctcggccca gctgacccgg
1963681 accagcccgc ccttgccgcg ggcgcgctgg tagcggcggc gccgccgcgg gtcggcctgg
1963741 atgtcggccc aggccgccac cggatcaccc aaacgtgcct tcgcctcccg atacatctcg
1963801 acaagcacgc cgcgggcgta cggatggcgc acccgcgtcg gcgaatacgt gtaccaggaa
1963861 aacgccgcgc cgcgcgggca gccgcggggc tcatactcgg gccggtccgg gcccaccgac
1963921 ggatagtcgg tctcctgcgt ctcccaggtg atgatgtcgt ctttgacgta gatcttccaa
1963981 gaacacgacc cggtgcaatt caccccgtgt gtggagcgga ccaccttgtc gtggctccac
1964041 cggtctcgat agaacacgtc gccgtcgcgg ccgccgcggc gggtcacggt acgcagatcc
1964101 gccgagatct cacccgggat gaagaaccgg ccgctgcgtg caagcagctc ctcgatgcgg
1964161 ctgccggtcc gtggtgtcac cgtcacctgg acgcctcctc actcaccggc tcccgcgcgt
1964221 gcagcgcggt gtaggtacac gcgaccagcg cggtcgccac cagcagcagc aacccgaccg
1964281 tgtagtcgtt gtcgaccggg tcgtaggtcg cgcccatcac cagcggcggg aagtaaccgc
1964341 ccaatccgcc tgccgcggcg acgattccgg tgaccgagcc gaccgatgcg gccggggcgc
1964401 ggcgggccac ccacgcgaac acgccgccgg tgcccacgcc gaggcagacc gccagggtga
1964461 tgaaggtggc cgccgaccac acctccggcg gcggctgcaa cgccgcggcg aacgccagca
1964521 gcgcggtccc ggcgagcgag gccagcacca cgtgcctcgg tgcgatccgg tcggagagcc
1964581 acccgcccac cggccgggcc agcaccgccg ccagggcgaa cccggcggtg cgagcgcccg
1964641 cgtcgaccgt ggagaacccg tagatcgtgg tgatgtaggt gggcaggtag ttgctgaacg
1964701 ccacgaaccc gccgaacacg atcgcgtaca gaaacgacat ctcccaggtc accggcaacc
1964761 gtgccgcggc cttgagcctg ggcagcaccg ggtcggcgtt gggccgaaag tagggtgcat
1964821 cacgaagcac gaccatggcc accacggcgg tcgacgcgag cgcggccgcg acgatggcgt
1964881 gggtggtgaa caggccgaac caccgtacaa accgcggggt gaagaacgcc gagagcgcgg
1964941 tgccgaccat gcccataccg aacacgccgg tggagaaacc gcgccgcgcc ggctggtacc
1965001 agttgttggc gaacgggatg ccgacggcga agatcgtgcc ggcaacgccc aggaagagcc
1965061 cgaaaaacac cagcaacgcg taggagccca tggttgccgc gaccccgacc gcgagcaccg
1965121 ggaggatcga cgccagcgtc accgcgatga gcatggcgcg cccgccgaag cggtcggtga
1965181 gcggcccggt gacgatgcgg ccaagggcac ccaccaggat cggggtggcg acgagcagcg
1965241 acgcctcggc gctggacagt gacatgtcac gcgcgtagct ggtcgacagc gggccgatca
1965301 ggttccacgc ccagaagttg accaccgaga tccaggtggc cagcacgaga ttggccgctt
1965361 gccctctcat cgacacgatc cggggtctcg gactccggcg aactccgcgc cccgcccgga
1965421 cagccatgcg ctaaccctgg cttcgatggc gccggctcag ttagggccgg aagtccccaa
1965481 tgtggcagac ctttcgcccc tggcggacga atgaccccag tggccgggac ttcaggccct
1965541 atcggagggc tccggcgcgg tggtcggatt tgtctgtgga ggttacaccc caatcgcaag
1965601 gatgcattat gaccagcgag ctgagcctgg tcgccactgg aaaggggagc aacatcatgt
1965661 gcggcgacca gtcggatcac gtgctgcagc actggaccgt cgacatatcg atcgacgaac
1965721 acgaaggatt gactcgggcg aaggcacggc tgcgttggcg ggaaaaggaa ttggtgggtg
1965781 ttggcctggc aaggctcaat ccggccgacc gcaacgtccc cgagatcggc gatgaactct
1965841 cggtcgcccg agccttgtcc gacttgggga agcgaatgtt gaaggtgtcg acccacgaca
1965901 tcgaagctgt tacccatcag ccggcgcgat tgttgtattg agggtgccgg cgcgttagcg
1965961 ccgacggaac gcctgcactg cggtaggcaa tgtcataaag atatggtctt cgccaatctt
1966021 atcgagaaga ctggcggccc tgagtgattc acgcaagtct tgtttgaccc gggccatggc
1966081 gaacactatt ccccgacgca gcagctcggt gcggagttgg tcgagcgcat ccagcgcagt
1966141 caggtcgacc tccacattgg attcggcgtt gagtacgaac cactcgactt gccccggatc
1966201 ctgatcgacc acggtcagtg ctcgcctgcg gaagtcttcg gcattggcga agcacaacgg
1966261 cgcgtcatag cgatacacca ccagcccggg cacgcgcttg gcctgcggat agtcatcgat
1966321 gtcgtgcatg ccggcaatgc ccggcacgaa cccgagaacg ctgtcatgcg gatgtgcgac
1966381 ccgacgaagc agttcgagga tggacagggc aaccgcggcg aggactccat agaacactcc
1966441 taggcctaac acggctgctg tggtggctag tgccagcatg agttcgctgc gccgaaaccg
1966501 cgccagtcgc cggaattctg acaagtcgat caagcgtagc gcggcatata ccaccaaagc
1966561 gcccagagcg gcgatcggaa acatggccag cagcccactc gcgaaaacca tcacgatgac
1966621 aacaagcccc aacgcgatca gcgagtacag ctgggtgcgg ccaccgacga cgtcggcgag
1966681 ggcggtacgg ctgctgctgg aactcaccgg aaaaccgtgt gtcagcccgg cggcgatgtt
1966741 gcaggccccg accgcgcgca gctcggcgtt ggcattgact tcctgacctc gacgagcggc
1966801 gaaggcgcgt gcggtcaaca caccgtcggt gaaggtaaca atcgcgatcc cggcagccgg
1966861 aatgatcagt gcccgcaagt cttccaccga aacgggcggc acacccggcg tcggcagacc
1966921 ggaaggtatc cgacccacaa tcgcaatacc tttggcatcc aaggacataa cggccactag
1966981 catcgtggcc gcaagaaccg cgatgatcgg tccgggggcg cgcggcgccc accgcgtgag
1967041 catagttagc agcgctagga cagacatggc taacacaaaa gtcggccagt gaactcgcgt
1967101 gacgctagtc gcgaaagagt gtacttcgct gaagaattcg ttgccttcga ccgaggtgcc
1967161 ggtgatagtg ccgagttggc tggagatcat gacaagcgcg atgccggcca tgtatccgac
1967221 gagcaccggc cgcgatcgca ggctggcgag gaaacctagt cgcgccgtgc cagcgagtag
1967281 gcagataagg ccgactagca atccgagggt tgccgccaga acggcatagc gtcgaagatc
1967341 cccggcggcc atcggagcga gcacggccgc cgtcatcaag gcggtggcgg attccgggcc
1967401 gattgaaagc tgccgggacg atccgagcag tgcgtaaatg gcaagcggcg cgatcgacgc
1967461 ccacagcccg gctgccggcg gtaggcccgc cacggtcgca tacgccatcg cttgcgggat
1967521 cagataggcg gccacggtca ggccggcgag gacatcgccg cgcagccaac gccgttggta
1967581 ttcgcggaac tgcaccaccc ctggtgccca gccggccgat gtcatcgtgg gaatcattgt
1967641 ccgacggctg gccgcttagc tagagtcggt ctagaacccg cccaatcttt atagaatcct
1967701 gaccatggaa ttggcggctc gaatgggcga gactttgaca caagcggtcg tagttgcagt
1967761 gcgggagcaa ctggcccgcc ggaccgggcg caccagatcc atttcgctac gcgaggagtt
1967821 ggccgccatt ggccggcgct gcgcggcctt accggtgctc gacacccgag ccgcggacac
1967881 gattctcggc tacgacgagc gcgggttgcc cgcctgatgg tgatcgatac ctctgcgctg
1967941 gtcgcgatgc tcaacgatga acccgaggcg caacggttcg agatagccgt ggcagcagac
1968001 cacgtttggc tgatgtcgac ggcgtcatat ccggagatgg cgaccgtgat cgaaacacgc
1968061 ttcggggaac cggggggacg tgaacccaag gtcagcggcc agcctctcct ctataagggt
1968121 gacgatttcg catgtatcga tattcgcgcg gttctcgccg gctgagccgg cgatgagcgc
1968181 cctgctggat ggggtgttgg acgcccacgg cgggctgcag cgatggcgcg ccgcggaaac
1968241 ggttcatggg cgggtacgca cgggagggct gttgcttcga acccgggtgc cgggcaaccg
1968301 cttcgcggac taccgcatca cggtgcatgt ccaacaggcc cggacggtct tggatccgtt
1968361 cccgcgtgac gggtaccgcg gagtcttcga gagcgggcag gtgcggatcg aaagccacga
1968421 tggcgcggtc atcagctcgc gcgcgcaccc gcgagcggcg ttcttcggac gctcgggcct
1968481 gcgccggaac atccggtggg acccgctgga ctcggtctat ttcgccggtt acgcgatgtg
1968541 gaactacctc accacgccgt acctgttgac gcgcgaaggc gtggcggtcg aggagggagc
1968601 gccctggcag caggagggcg agacctggcg gcgcctgatt gtgagcttcc cgccggatat
1968661 cgacacccac tcgcctcgcc agacctttta cgtcgatgcc agcggtctct tgcgccgcca
1968721 cgactacgtc ccggaggtcg ttggccactg ggcacgggca gctcattatt gcgccgaccc
1968781 cgtggatgtc gacgggtttg tattcccgac ttgccggtgg gtccacccga tcggcccggg
1968841 gaatcgctca ctgcccttcc caactctggt atcgatcctg ctgaccgaca tccgggtcga
1968901 gaccgattag gtttcgccgg aagtcgccgc acctcgcggt tgctgaaacc attagcctta
1968961 tgcctgtcac accaccgcgg ttggcggggt gaggagtcgg gcgatggatg gcaccgcgga
1969021 atcgcgggag ggtacgcagt tcgggccgta tcggttgcgg cggttggtgg gtcgcggcgg
1969081 catgggcgac gtctatgagg ccgaagacac ggtgcgcgag cggatcgtgg cactaaagct
1969141 gatgtcggag acgctctcca gcgatccggt cttccgcacg cgtatgcagc gcgaggcccg
1969201 caccgcgggg cgcctgcagg aaccgcacgt cgtgccgatt cacgacttcg gtgagatcga
1969261 cgggcagctc tacgtggaca tgcgcctgat caacggcgtg gatctggccg cgatgctgag
1969321 acgccagggg ccgctggccc caccgcgagc ggtcgcgatc gtgcgccaga tcggctcggc
1969381 gctcgacgcc gcgcacgctg ccggggcaac gcatcgcgac gtcaaaccgg agaacattct
1969441 ggttagcgcg gatgacttcg cctatcttgt cgatttcggg atcgccagcg ccaccaccga
1969501 cgaaaagctg acccagctcg gcaacacggt gggcaccctc tactacatgg cgccagagcg
1969561 gttcagcgag tcgcacgcaa cttaccgcgc cgacatttat gcgttgacct gcgtgttgta
1969621 tgagtgcttg accggatcac cgccgtatca gggagaccag ctcagcgtga tgggcgcgca
1969681 catcaaccag gcgatcccgc ggcccagcac ggtacggccg ggtattccgg tcgccttcga
1969741 tgcggtgatc gcccgtggca tggccaaaaa tccggaggac cgctatgtca cctgcggtga
1969801 tctgtcagcg gcggcgcacg cagccctggc caccgcggat caggatcgtg ccaccgacat
1969861 cttgcggcgc agccaggtgg ccaagctgcc ggtgccatcg actcacccgg tgtcaccggg
1969921 tacccggtgg ccgcagccga cgccatgggc tggcggggcg ccgccatggg ggccaccgtc
1969981 gtctccgctg ccccggtcag cccgccagcc ctggttgtgg gttggtgttg ccgtcgccgt
1970041 cgtggtggcg ctggcgggcg gcctgggtat cgcgcttgcc catccgtggc ggtcatctgg
1970101 accccgcacg tcggcaccgc cgccaccgcc gcccgcagat gcggtcgagc tccgcgttct
1970161 caacgacggt gtctttgtgg gtagctcggt ggcgccgaca acgatcgaca ttttcaacga
1970221 acccatctgt ccaccctgcg gcagtttcat caggtcgtat gcgagcgata tcgataccgc
1970281 ggtggccgac aagcagctgg cggtgcgcta ccacctgctc aacttcctcg acgaccagtc
1970341 gcacagcaag aactattcga cgcgagcggt ggccgcctcg tactgtgtag cggggcaaaa
1970401 cgacccgaaa ctctacgcca gcttctactc cgccctattc ggcagcgact ttcagccgca
1970461 agagaacgcc gcatcggatc gcaccgatgc cgaactggca catcttgctc aaacagtcgg
1970521 cgccgagccc acggcgatca gctgtatcaa gtcaggagct gatctgggca ccgcccaaac
1970581 gaaggccaca aacgccagcg agacgctggc cggcttcaat gccagcggta cgccgttcgt
1970641 gtgggacggc agcatggtcg tgaactatca ggatccgagc tggctcgcga ggctgatcgg
1970701 gtagcgcggg tggtgtggcc tcgtcccgga caattccgct tgctctcgca gcatgtccgc
1970761 agcggtgcgc ggttgtgacg gtgaattcac gatgctcgcc gttgatgtcg gcaggtacca
1970821 ccgcggtgtg gcttgcgtcg cggacggtgc ggtcagattc ggcgatggtc ccgagggcgg
1970881 cagctactat gccaacgaca ggcgcccaca aatatcctgc ggttgagttg cagaccgggt
1970941 gggtcgttca ccgatccact gtagggccgg tgactcagaa cgtggccgtt aattcgaaac
1971001 ccggcccagg ttgccaaccc gaagatttcg ggcgccgacc acattccgca gtcccgaaca
1971061 attcacgcac cacaaacacc ccacacagtc ggtgcagcgc acgcagccga tacaggccac
1971121 gcaccgggtg caggtgatgc atgctaggca tgccacacac tgccggacag ccacgcacaa
1971181 tacggtcagc agactgccga ttatcccgac gctgcccgcc gtggctgccg ccccggctat
1971241 cgcgacgctg cccgcggtcg cgaccgagcc ggcgactgcg acgctgcccg cggtcgccac
1971301 cgagccggcg actgcgacgg cgcccgtggt cgcggccgat cccgcgacgg cgatgctgtc
1971361 gatgctggcg atcgagcggt taattaccat gtgcggcttt cggtagccgg cagtcgtcgg
1971421 ccacgggcca ctgtgccgga catggtccaa gtttggtcag gtagcccagt tgtgagcggc
1971481 accaagggga taccggggcg attacgccgg cggtaacatc gcgcacgaat tgttcccagg
1971541 acaaccagcg gatcgcgtcg acctcgtccg agttcggccg gggctgttgg tcaacctgga
1971601 ctcggtagac ggggcagatc tcgttttcca cggtgccatc ggccatagcg gcccggtagc
1971661 ggaaccccgg caggatcaga tcgacccgat ctggggtcag tccgagttcg gcagcgagcc
1971721 gccggcgtat ggcgccgggt agcgattcgc caggcagggg gtgcccgcag caactgttgg
1971781 tccataccgc cggccacgtc ctcttggtgg cggcccgccg cgtgatcaac agctgatcgt
1971841 gcagatcgaa cacatagctg gagaacgcga ggtgcaaagg ggtgtcgccg gtgtgcacgg
1971901 tggccttgtc ggccacacct gtcgcgtcgc cgcggtcgtt gagcaaaacc acccgctcga
1971961 tcggtggagc tggccggtag ctgcgggtca tgccagacct ccttacgctt gcttgcgagg
1972021 gtcggttcgc ggccccaacg ctggcaaact accggagagt cacttgtcgc gtgcggagtt
1972081 ccacgattct cgtcgagtgt cgcaagccct gccctcctgg cgggctacga tgccgccatg
1972141 ccgctcgcgg aaggttcgac gttcgccggc ttcaccatcg tccggcagtt gggatccggc
1972201 gggatgggcg aggtgtacct ggcccggcat cccagactgc cccgccagga cgcgctcaag
1972261 gtactgcggg ccgatgtgtc agccgacggc gaataccggg cacggttcaa ccgcgaagcc
1972321 gatgccgcgg cgtcgctgtg gcatccacac atcgtcgccg tccacgaccg cggcgagttc
1972381 gacggccagc tctggatcga catggacttc gtcgacggca ccgacaccgt atcccttctc
1972441 agggatcgtt atccgaacgg gatgcccggc cccgaggtca ccgagatcat cactgcggtg
1972501 gccgaagcgc tcgactatgc ccacgaacgt cggctgttgc accgcgacgt caaacccgcc
1972561 aacatcctga tcgccaatcc tgattcacct gatcgtcgaa tcatgttggc cgacttcggg
1972621 atcgccggct gggtcgatga tccaagcgga ttgaccgcca caaacatgac tgtgggcacc
1972681 gtgtcatacg cggctccgga acagcttatg ggcaacgagc tcgatggacg ggccgaccaa
1972741 tacgcactag ccgcgacggc gtttcacttg ctgaccggct ccccgccctt tcagcacgcc
1972801 aaccccgccg tggtgatcag ccagcatctc agcgcgtcac ccccggcgat cggcgatcgg
1972861 gttcccgagc tgacaccgct ggacccggtc ttcgccaaag cgctggccaa gcaacccaag
1972921 gaccgttacc agcggtgtgt cgacttcgcg cgcgcactcg gccatcgtct gggcggcgcg
1972981 ggtgatcctg acgacacgcg ggtgtcgcaa ccggtcgccg tggccgcgcc cgcgaaacgc
1973041 tcgctgctgc ggaccgccgt catcgtcccc gcggtgctgg cgatgctgct ggtgatggcc
1973101 gtcgcggtcg ccgtgcggga gttccagcgt gctgacgacg agcgtgcagc gcagcctgcg
1973161 cggacgcgga ccaccacatc ggccggcacg accacttcgg tagcccccgc gagcacaacg
1973221 cgcccggccc ccacgacccc gaccacgact ggcgccgccg acaccgcgac tgcatcgccg
1973281 accgctgcgg ttgtcgccat cggcgccctc tgcttcccgc tcggcagcac cggcaccacc
1973341 aagaccgggg cgacggccta ctgctcgacg ctgcaaggca ccaacaccac catctggtcg
1973401 ctgaccgagg acaccgtggc cagtccgact gtgaccgcca ctgctgaccc gacggaggcg
1973461 ccgctgccca tcgagcagga atcgccgatt cgagtgtgca tgcagcagac cggccagacc
1973521 cgacgggaat gtcgcgagga gattcgcaga agcaacggct ggccgtgatg gtcggcttgc
1973581 ctgaccgggt gcacccgccc cggcgtcggc tgcggtcccg atacagttgg tgccgatgag
1973641 ccaaccagcc gccccgcccg tgttgaccgt gcggtatgag ggatcggagc gcacgttcgc
1973701 cgcaggacac gatgtcgtcg tcgggcgtga cctgcgcgcg gatgtccgcg tcgcacaccc
1973761 cctgatctcc cgggcacacc tgctgctgcg attcgaccag ggtcgctggg tcgccattga
1973821 caatggcagc ctcaatgggc tctacctcaa taaccgtcgg gtgccagtcg tggacatcta
1973881 cgatgcccag cgagtccata tcggaaaccc cgacggtccg gcgctggact tcgaagtggg
1973941 ccgccaccgg ggttcggccg ggcgaccacc ccagacgacg tcgatacgcc tgcccaacct
1974001 gtccgcggga gcgtggccca ccgacggccc gccgcagacc ggcacgctcg gctccggcca
1974061 gctacaacag cttccaccgg ccaccacccg gatacccgcc gctccgccat cgggaccaca
1974121 gccgcgatac cccaccggtg ggcaacagtt gtggccaccc agcggaccgc aacgggcgcc
1974181 gcagatttac cggccaccca cggccgcacc gccgccggcg ggtgcccgcg gcggaactga
1974241 ggcgggaaac ctcgcgacat cgatgatgaa gatcctgcgg ccaggcaggt tgacggggga
1974301 gttgccgccc ggtgccgtca ggatcggccg ggcgaacgac aacgacatcg tcattcccga
1974361 ggtgttggcc tcacgtcacc acgccaccct ggtcccgacg cctggcggca cggagattcg
1974421 ggacaaccgc agcatcaatg gcaccttcgt caacggcgcc cgggtcgacg cggcgctgct
1974481 gcacgacggc gacgtcgtga ccatcggcaa catcgacctc gtcttcgccg acggcaccct
1974541 ggcgcgccgt gaagagaacc tgctggagac ccgcgtcggc ggcctcgacg tgcgcggggt
1974601 gacctggacc atcgatggcg acaagacact gctggacggc atctcgttga cggcgcgccc
1974661 cggtatgctc accgccgtca tcggtccgtc gggcgctggc aagtcgacac ttgcccggtt
1974721 ggtggctggg tatacgcacc cgacggatgg cacggtgacg ttcgagggcc acaacgttca
1974781 cgccgaatat gcctcgctgc gcagcaggat cggcatggtg ccacaggacg acgtggtgca
1974841 cggtcagctg accgtgaaac acgcgctgat gtatgccgcc gaactacggc tgccgccgga
1974901 caccaccaaa gatgaccgca cccaggtagt tgcccgggtg ctcgaagaac tcgagatgtc
1974961 caagcacatc gacaccaggg tcgacaagct gtcgggtggt caacgcaagc gggcgtcggt
1975021 ggcgcttgag ctgttgaccg ggccgtcact gctgatcctc gacgagccga catccggcct
1975081 agatcctgcg ctggaccggc aggtcatgac catgctgcgg cagttggccg acgccggtcg
1975141 ggtggtgctc gtggttaccc actcactgac ctacctggac gtctgtgacc aggttctgct
1975201 gttggccccc ggcggcaaga ccgcgttctg tgggccaccg actcagattg gtccggtcat
1975261 ggggaccacg aactgggccg acatcttcag caccgtcgcc gacgacccag acgcggccaa
1975321 agcccgctac ctggcgcgga cgggtccgac cccaccaccg ccaccggtcg agcaacccgc
1975381 cgaactgggc gatccggccc ataccagctt gtttcggcag ttctccacga tcgcgcggcg
1975441 acagttgcga ttgatcgttt ccgaccgagg ttacttcgtc tttctggcgc tgttgccgtt
1975501 catcatgggt gcgctgtcca tgtcggtacc gggcgacgtg ggcttcgggt ttcccaaccc
1975561 gatgggtgac gcgcccaacg agcccggcca gatcctagtg ttgctgaatg tcggtgcggt
1975621 cttcatgggg accgcgctga ccattcgtga cctcatcggt gagcgagcca tcttccggcg
1975681 cgaacaggca gtcggcctgt ccactaccgc ctacctgatc gcgaaggtct gtgtctacac
1975741 cgtgctcgcg gtggttcagt cggcgattgt gacggtgatc gtcctggtcg gcaagggcgg
1975801 tccgactcag ggtgccgtag cgttgagcaa gccagatctg gagctgttcg ttgatgtcgc
1975861 ggtgacctgt gtcgcctcgg cgatgctcgg attggcgctg tcggcgatcg ccaagtccaa
1975921 cgaacagatc atgcccctgc tggtcgtggc ggtcatgtcg cagctggtgt tctccggagg
1975981 catgattccg gtcaccggac gtgttcccct tgaccagatg tcctgggtca caccggcgag
1976041 atggggtttc gcggcgtcgg ccgctacggt cgacctgatc aaattggtgc ccggtccgct
1976101 gaccccgaag gattcgcatt ggcatcacac cgccagcgcg tggtggttcg acatggccat
1976161 gctggtagcg ctcagcgtta tctacgtcgg ctttgtgcgc tggaagattc gcctcaaggc
1976221 gtgctaggcg gcagttcact gcccaaccca ggtggaatta acgggaatgg ctgtctcact
1976281 caccggctca acaggtggcc ttgggcgcgc gacgcgaccg cacccgccga ccgtgacgtg
1976341 cgactgattc tgagctaacg cacgcagggg gaactcgagc ccggtgacca gctcgagcgc
1976401 ggcgccgggc gggtgagatc gacgtgtggg tcgccaacgc cgtgctgcca gcctccggca
1976461 agctcgacag catcaccgcg gagccggttg gccgcgcgct gcggggacgg cgcgcttgac
1976521 ggcgaacgcg cccgagatcg ccctcctcgg cgtcgccgac caggtcgcgg ccggtcagat
1976581 tgacaagcgg tgaagccggt tgccgggtgg tgtctgctcc ggccgaccct ggggccgtcc
1976641 atggtggcat cctggcctgg tggggctact gattcggcta gccgagttgc tcgttgtgat
1976701 gctgccgctc atcggagtgc tatatgtcgg catcaaagcg ctgtcgtcct tcacgcggcg
1976761 gctaggggag gcgtctggcg atcttgcgtc ggatagcccc gcgatgccac gcccaaccac
1976821 tgtcgaaaac gacgcagcgc ggtggcgggc gatcactcgc gcggtcgagg cgcacgagcg
1976881 aacggatgca cgctggttgg aatacgagct cgacgccgcc aagctgctcg acttcccggt
1976941 catgaccgac atgcgggacc cgctcacgac ggcatttcac aaggccaagc tacaagccga
1977001 ctttcacaag ccgttgcggg cggaagatct tctcgacgac ccggacgccg cgggccacta
1977061 tctcgatgcg gttcgggact atgtgaccgc gttcgacacc gcggaggccg aggcgatgcg
1977121 cagacgcaga accggctttt cccgcgagga acagcagcgg ctggcaagag cgcaaagcct
1977181 gctgcgggtg gcatccgacg ccggcgcgac ggcccaggaa cgcgagcgcg catatcgttt
1977241 ggcgcgcacc gaactcgacg gactcatcgt gttgccggac cgtacgcggg ccggcatcga
1977301 gcgggggatc gccggcgagc tcgatgacta aggctgacct ttcggcaccg cgtcgccgtt
1977361 gctgtgccac gaccacgcat agagcgccca catgacgatg ggtagcagga tgtcggtcca
1977421 cagcgggacg ccgatgttgt atgggttggt gttgttctcc accacccagt agtagatgtg
1977481 gccggccgcg tctccgacgt actggatggt gagcaccacg attgtcgcca gccagaagtg
1977541 cccgcggaag cggtacgcca tcaggccgac caccccgatt gccaggtcgc ccattgcgtt
1977601 ctcccattgg aacccgccgt cgccgcgcgt atagccgatc aactcggcgg tccgctcgcc
1977661 gtcgaagacg tggtatcccg cgccgatgat cgataccacg cccacgatca gcaccatcca
1977721 ccacagcata tggatgtccg cggctgggcg gtgccggtga cgccggctct gcacgaacgc
1977781 accgattagc gcgacgatta ccccgacaat ggtgaacatt ccaacaccct tccctagctt
1977841 tagggtcccg tcatgctgtc gaatctcatt gaccgcacgc aacactagcg gacgggctgg
1977901 cgctcaccgc tgttgcgggc gtcccgagaa cgccggccga gtaatggggg agcggacctt
1977961 tccgtacttc atatcgcttt tgccggtccg gacgcgtggt ggtaagcgct gcctcgtggt
1978021 tcgcgcaccc acagggtgtc cgctttgccg accgcggttc cctcgtcgat caactggcgc
1978081 ttgagcacct tgtgtgtggc ggtgctggga aggtcggccg cgatgcggat gtatcgtggc
1978141 cgggctttag tggataggtc aggctgggcg tccagaaatg cttcgaacgc gtcagggtcg
1978201 aaggtgtcac ctgctcgcaa gaccaacgcc gccatcacct gatcgccgac gtattcgtcc
1978261 gggacggcat acaccgcgac acggttaata gccttgtatc gtaatagaat tcgctcgatt
1978321 ggtgccgctg tcaggttctc gccgtctacc cgcatccagt cggcggtgcg gccagcaagg
1978381 tagatccagc cttcagagtc ccggtatgcg aggtctccag accagtacat gccgtggcgc
1978441 atgcgctcgg cgttggcttc ggggtcattg tagtagccgg tgaagaagcc cgaccccgtc
1978501 gtgttgacca actcacctat ggcttcatcg gcgttggtga gtgctccgtg agcgtcgaac
1978561 cgcgcgacgg cgcactcggt gacggtttcg ccgttgtaca ccgcgacccc gtgggctccc
1978621 cggccgatcg agcccggtgg cgtgccgggt tcgcggatca cgatgaccgc gttctcggtc
1978681 gagccaaagc cgtcctcgac ctggactccg aagcggcgtg agaattcctc gatgtctttg
1978741 tcattggcct cgttgccgaa agccacccgc agcggattgt cggcatcgtc gtcgcgttcg
1978801 ggggtggcaa ggatataggc gagcggcttg ccgacgtagt tcatataagt ggcgtggtat
1978861 cggcggacgt cgtcgaggaa gccggtcgcc gaaaacgtcg ccggcgcgat cgcggcaccg
1978921 gagaccaccg ctggcgccca tcccgcgacc accgcgttgg agtgaaacag cggcatggat
1978981 acatagcagg tgtcctgttc ggtgagcccg aagcgctcgg tgaggctacg cccggcgaac
1979041 gtggccatta ggtgtgacac cggtaccgct ttgggatttc cgctggtgcc ggacgtgaag
1979101 atcatcatga acggatccat cgtgtcgact tctcgatagg ggacaaaggc gccgtcacca
1979161 gccaccaatt cagcccaccg cggtgtcgag gtatcaagga tccgcgcgcc cgcgaggtct
1979221 aaaccgtcca acagcgctcg gtggtcggca tcggtcacca cgatctggca atcggctcgc
1979281 ctgacgtcag cggccagtgc atcgccacgt cgcgttgtgt tcaggccaca cagcacatag
1979341 ccgcccaacc cggccgcagc cagctgggcc agcatctcgg gcgtattccc cagcagagag
1979401 ccgatatgcg tcggacgttg cggatcggcg attgtgatga gggccgccgc gcgggccgcc
1979461 gactccgcca ggtactgact ccaagtccat tgcagaccac cgtatttcac ggcaatcgtt
1979521 ggatcggata cgtgctggcg caagagcgat tgaatcgtgt cggtcatgaa ttcgctccca
1979581 tgtcgagtcg cgggctttgg ccgcgacgct gtcatccagc atgatcgcca cgatgccatc
1979641 aatggccagg aggtcgcgac atgacaacaa gatcaccacg ccggcagtgg attgcctcac
1979701 gatcgaacgt ctagattctc ccgcgtccgg cgcccctcag gtcacccctt atgctagggc
1979761 gctaatgggc gagacaacca cgtgcgcgat catcggcggc ggcccggccg ggatggttct
1979821 gggcctgctg ttggcgcggg caggtgtgca ggtcaccctg ttggagaagc acggagactt
1979881 cctgcgcgac tttcgtggcg acacggtgca tccgacgacg atgcggctac tcgacgagct
1979941 tgggctgtgg gaacgctttg cggctttgcc ctacagcgag gtccgcacgg ccacattgca
1980001 ttcgaatggt cgcgcggtga cctacatcga cttcgagcga ctgcatcagc cctaccccta
1980061 tgtcgcaatg gtgccgcaat gggacctgct gaacctgctg gcggaggccg cccaagcgga
1980121 accgagcttt acgctgcgga tgaaaaccga ggtgaccggg ttgctgcggg agggcggcaa
1980181 agttacgggg gtgcgctatc aaggagccga gggcccgggt gaattgcggg cggaattgac
1980241 cgtggcgtgc gacggccgat ggtcgatcgc ccggcacgag gctggactga aggcgcgtga
1980301 attcccggtg aactttgacg tgtggtggtt caagctgcca cgtgaaggtg acgccgagtt
1980361 ctcgttcctg ccgcgattct ccccgggcaa ggggctcggc gtgatcccac gcgaaggtta
1980421 tttccagatc gcctacctcg ggcccaaggg aaccgacgct cagttgcgcg agcgaggtat
1980481 cgaggaattc cgtcgggacg tcagcgaact gctgcccgaa gcgacggcat cggtggcggc
1980541 gctagcgtcc atggacgagg tcaagcacct caacgtcaag gtgaatcggt tgcgtcgttg
1980601 gcacattgat gggctgctgt gcatcggcga cgcggcgcac gcgatgtcac cggtggcggg
1980661 agtcggcatc aacctagcgg tccaagatgc ggtcgcggca gcgaccatct tggccgaacc
1980721 gctgcgtgag catcgagtca gcagccgcca cctggcagcg gtacggcgtc gtcgcgcatt
1980781 tcccaccgcg gtgacccaag cggtgcagcg ggtgttgcac cgaaggctgc tcggcccgct
1980841 gctgcagggc cgggacccca cgccgccggc ggccctgctt ggcctggtcg aacggctgcc
1980901 atggctctcg gcggtgcccg cctactttgt gggagttgga gtccggcctg agcatgctcc
1980961 ggccttcgca cgtcgcgggc ccggcaaccg caaaggccct tgagccgaca tgcgcgccgc
1981021 cgcgaatcgg cgtcttgggt atagcccgga tagcgccgtt ggcgctcatc aagccggtca
1981081 gcgggagcgt cgtggtggca gcacgtgatg tgtcgcgggt ggcgcgacca tggacgctgg
1981141 ctgctatgcc gtccacatgg cccacacgtt cggtggggcc acgccggaag tggtttcggc
1981201 gcaagccaaa ttacgcgatc cagcggtcga tcgggccatg acggccgaac tgaaatttcc
1981261 aggcgggcac accggcggga tccgctgttc aatgcggtcg tcggatctgt tgaatgtgag
1981321 cgctcgagtg gtcggcgacc gtggcgagtt gcgcgtgctc aatccggttg tgccccaact
1981381 cttccaccga ttgccgcccc tcgcatgcgt atcagctcga cgctttcgct gccgcagtgc
1981441 tgcgcgggca agcggtcaag acgacgccca aggacgcggt cgagaacatg agcgcgatcc
1981501 acgcgatcta tcgggccgcc gggctcccat cgcgcaaccc gagctgaata tggtcgccgc
1981561 gagcgggtcc gccgcctgac aggccaatgg cgtcggtcgc ttacccgcca gggttaggac
1981621 gtggtgcctt ggaagaaacc cgccaggttg gtgccgatat tggcaaagcc ggaaacgacg
1981681 ctggctaccg agaacggcag gatgcccctg ttggcgaagc ctgagacgcc gctgccaagg
1981741 ttggaaaagc ccgaggatag cccgccgaag ttctgatagc ccgagccgcc caacagcccg
1981801 gccgggttgg tgttgaacca acccgagagg cccgagccgt tgttgccgaa gcccgagttg
1981861 ccgcccgcac cggaattgaa gaagcccgac gaaggcgcgg tgctcgagtt gaagtagccc
1981921 ggccccccgg ggatcgcgaa ggccccgatc gtggtgctgg gcaggtggat gccgggaacg
1981981 gtgagcgggg gcgtggtgaa gccccccacg ccgatcggct cgatggtgag cggtggggtg
1982041 gtgatgggtg gggtggtgat ttgggggagg gtgaagccgg tgaggttgat ggggtcgatg
1982101 gtcagcggtg gggtggtgat gggtggggtg gtgatttggg ggagggtgaa gccggtgagg
1982161 ttgatggggt cgatggtcag cggtggggtg gtgatgggtg gggtggtgat ttgcggcagg
1982221 gtgaacccgc cgacgccgat cgagttgatg gttagctccg gggtgatgat ttcctgggtg
1982281 gtgatctgcg gcagagtgaa gccgcccacg ccgatcggag ggatcgcgaa ctccggggtg
1982341 gtgatagctg gggtggtgat ctgcggcagg gtgaagccat cgacgttgat agcggggaca
1982401 tcgatcccgg gtatgttgaa ggcgggcaga aagaatgaac cgatgacaat agggccggtc
1982461 aatgtgtatg ggtgaaccac caattgtggt aagtcaaact caccgaagat gagggcgcca
1982521 ttggtgaaag tactaagccc gccgccgggc ggctgaagcg caggcacatt ggtctggaat
1982581 tgtagggtaa agggtattcc aaaagccggt actgttatcc taggtgtgct taggaaaaca
1982641 tcccagccta tggagggcag gccaaattgg cccacgccaa tctggccgac cgttatcggt
1982701 tgagtatgta tcgcaggtag actaaagcca ccgattgtga tacccgcggg tatcgtcagc
1982761 tgcggaatag ttacttccgg aatctgcaat ggcggcaaat taaaagcacc caccgtaatg
1982821 ggcgggaccg tcaccggcgg aatggctacg gaaggaatac tcagcggagg caactgaaag
1982881 ccgcttacgg tgatgttggc gggtgtggtg gcggccggga tgttcaacga cggcaacgtc
1982941 aacccgggca ggctgaaggc gccgacggtg atgttggctg gtgtggtggc ggccgggatg
1983001 ttcaacgacg gcaacgtcaa cccgggcagg ctgaaggcgc cgacggtgat gttggctggt
1983061 gtggtggcgg ccgggatgtt caacgacggc aacgtcaacc cgggcaggct gaaggcgccg
1983121 acggtgatgt tggctggtgt ggtggcggcc gggatgttca acgacggcaa cgtcaacccg
1983181 ggcaggctga aggcacccac ggtgatgttg gctggtgtgg tggcggccgg gatgttcaac
1983241 gacggcaacg tcaacccggg caggctgaag gcgccgacgg tgatgttggc cggtgtggtg
1983301 gcggccggga tgttcagcga cggcagcgtt attgccggca gactgaaggc gggaaccgat
1983361 atccccggta tttgcagcgg cggcagagtc agatcaggtg tcgtaatact gaactgcagg
1983421 ctgccctgcc ccacgccccg gtagaagacg ccattgttca tgtcacccgt gttgaacagc
1983481 ccattattca tgtggccaat attgaagaca ccagtgttga tatttccggc gttgaggaaa
1983541 cccgtgttag catttcccgt gttgaacgtg ccggtgttgg acgaccccgg attgaagtcg
1983601 cccatgttat aactgccggt gttcaggctg cctgtgttcg cgttgccgac gtccaacata
1983661 ccggtgttaa acgagcccgc attgaagaag cccgtgttcc cgtgtccaga attccagcca
1983721 ccggtgttga aattacccga gtttccgatg ccaaagtttc cattgccgga gttgaagaag
1983781 ccgacgtttc cgctgcccga gttgaacaat ccgaaattcc cggtgcccga gttgagcccg
1983841 ccgattccga tctggttgtt gccggtaaga ccgatgccga tgttgttgtt gccagtgttg
1983901 ccaaagccga agttgcccaa gccggtgttg gcaaacccgg tgttgagatt gccaaggttt
1983961 cccacgccga cattgttgct gccgaggttc ccgaagccga tgttgttatt acccaggctt
1984021 gctgagccga tattggagtt accgaaattt ccggacccga aattgtagtt gccaaggttg
1984081 gcgttgccga tgttggcaag gccgttgttg gcgttgccga cgttgccacc gccgacgttg
1984141 gctatgccca ggttgatggc ggtgggtccg cccgcaagcg ccggtatgcc tgcggctgcg
1984201 gtcatggcgg ccgcaggcgc gccgctggcc aaccaagccg gcaagccagc caggttctgc
1984261 agcggtttac tgaacgggga cagcgccgag gcgatcgccg atgccccggc atggtaggca
1984321 gacatcgccg acacatcggc agcccacatt tgctcgtacg tggcttcaat ggcagcgatc
1984381 gccggagcgt tctgtccaaa caggttcgac atcaccagcg acaccaggtc ggcacggttg
1984441 gccgccacca gcatcggctg caccaccgcc gtcttgaccg cttcaaactc ggctatcatc
1984501 gccgcagcct gagcggccgt ctgctcggcc tggaccgccg ccgcggcaag ccacgccgca
1984561 tagggggctg ccgctgccgc catcgccgac gacgacgcgc cctgccacgc cccgcccacg
1984621 agtccggatg tcactgagcc gaaagaggct gcggccgagg ccaattccat ggccaacccg
1984681 tcccaggccg tcgcggccgc cgccatcggt tccggccctg ccccggcgaa tatcagcgct
1984741 gaattgatct ccggcggcag tacagaaaaa ttcatcgtcc agccttccct gcgtgccccg
1984801 cgtgatcagc ggtaaaccgt ggccggtgag tggctcttgg cccacaagct agacgctgaa
1984861 ccgtcgtggc cacataaata tcgcgcacaa atggccacga ctcataggtt tcgtaaattt
1984921 gatttacaaa aggcgctctc gggtcatgcg gaccgcaagc ggcgtccgaa cgcaggggct
1984981 atggcagcac ggtgtgcatc aacatcacgt tgtatgccga ccacaaagac aggttaaagt
1985041 agacgtcttt gcccgtcgac cagggatgca tcatcggcgc gtagatgccg ccgggcatct
1985101 gccatgacga caccagcatt tgctctgcgc tccacggtcc ttgcggagcc ggcgcggtcc
1985161 ttgccaccac gtcgttcata ccgttggtgt agagcgccag gtattgcttg aggtaggtgt
1985221 tgtattggac ggacatttcg cccaccgggc ccggaataac gggtgttgcc gcgtccggct
1985281 tgtttggaac ccaggagttc gagtcgccgt tccagtactg gtacttggtg aggtcgggca
1985341 caaagcgctg cggaactcgt gccagatatg ccgaaccgcc tcgcccgggc ggggtcccga
1985401 acgagtagag gtaaccgtcg ttggacttga ggtacgcccc catctggaag ttctcatttc
1985461 ccggaacgaa cctggctttt ccgccgctgt ccggtccgga cgcgcggatg gtgcccggga
1985521 agacccccca ggtctgacca ttgtccttgg acaccgcgat gcccgagtag ttcgtcgtcc
1985581 attccccatc acggccccaa ttcctgatgg acatgaagtt gacgtattgg gttttgccga
1985641 cggcgatgcc cgcggtcgga atgatccccg tctcgtcgcg cgcccatttg atgctgttga
1985701 tgagctgttt ggagaagccc ggttggcgta ccggtgagcc ggaatatctg ttggaagcgt
1985761 caccggatgt cacatgaact ccgttgccca ggtcgcggtc ttggctgcgg aacagcgtgt
1985821 tgtatcgcca ttgatggcca tcgacagcgc agtagccgaa tgtgtcgccg aagatcatga
1985881 gcacctgacg gttggcggga tcgccgttat cccaaggaat tccgaggtcg gtcccggaga
1985941 tgccgaagcg ttccagggtc ttgttggggc tgtccggtcc ggtcacccac tcggcgaggg
1986001 atgtggtagc cccggcgagc gtggcaccag gatccggcgc cgccgccgga gcagggtcgg
1986061 gtgctggggc tgggttcgga gttagctgag tggcattcgg gggttgtggg cccgtggctg
1986121 gcggattggg tgccggattg ggcccaggat tggccctggg gactagcgct tgctgttgta
1986181 gcggcgcggc atttctagca cccgggttga gcaatgcgga tatcagtgga cccagcttgg
1986241 gtagcggtgc acggtcgttg gcaccgcgag gcttgcgtcc ggtcggtatc ggaccgtgtc
1986301 caggtcgtac cgggccgagc gccgtggccc cggggtcggt cacaatggcg ctcggtggcg
1986361 gcggagcgtt cgcggcgtct ccgctgcacg gcgccgccat cgctggtggc gccaggccta
1986421 ttggaaccat gagtccaata gcggccgccc acgccagcga taccgacacg attcgaggaa
1986481 tcggcgacat gtcacacctt cccgggctgg acgttgcaat tgacgtccgc agttcgctga
1986541 tgtgacgata gtgatctctg ggactcttgt gatcagtgat ccactgatag gtatgcctcc
1986601 gtgaccgtgt cgcaacccat ctgttcatct ccgacctgcg ctgctgcact cggacttggt
1986661 accggtacat tcaaggccca tcggggccgc ggataccacg accaccggtg ccgaacatcg
1986721 acgatccgat caatttgcgt ccactgtcgc ccggacaggt caacaaggtg tggctctggc
1986781 aatcgctacc cggtccctgg atcgggtccg cacggaatac cgtgtacctg accggatttg
1986841 agttcctcga gccttagcac ggaccgctcg gaataccacg ggtaggcgtg gtttcctgcg
1986901 tgggcatgat ctgtggatca ggaacccgat acgggattcc acggtttatc gtgcccagcg
1986961 ccgcgttggg cacgcactgc ggcaccgttg atagcgcgtg cagcccggga taatccaggt
1987021 tgggccatga tgagttgggc gggacagcga agttgaacgt tgacgtcatg tcgccggtca
1987081 cactgcgccg ccaagccgtg aggttgggaa ctggcacccc gaaccgagtt tcgagcaatc
1987141 tcagctgtga ggtgtggtca aacgtgtcgt gaaccatctg cgggccacgg ctgtacggcg
1987201 aaatgacgaa gcagggaacg cgaaagccca aaccgatcgg cccgcgtatt ccgccggagc
1987261 ccggcacctg atcgatgtca ggcaccgtga catattcgcc gggagtcccg gccggcgcgg
1987321 tagcaggaac aacgtggtcg aaaaagccgc cgttttcgtc gtagctgacg atcagcgccg
1987381 tcttttccca caccgcagga ttggcaagca atattcttaa gatgttgacg attgcgaaag
1987441 ccccggccgc ggctggaacc gcaggatgtt cggattcgag aacattggga atcacccagg
1987501 agacccgcgg cagtctattg gctaagacgt cggccgcgaa gctcgcggga tagcttggtg
1987561 ccacgccaaa gcggacaaga tctgacctgg gatcggctga ctgtttgaaa gacgtcacaa
1987621 gcgagccgta agtaagaacc gaggagatgg gcccgagtgt cttgttgcga tacaccttcc
1987681 agctgacgcc ggcatcgcta agtgaaccgc cccggtgagt ccggagactc tctgatctga
1987741 gacctcagcc ggcggctggt ctctggcgtt gagcgtagta ggcagcctcg agttcgaccg
1987801 gcgggacgtc gccgcagtac tggtagaggc ggcgatggtt gaaccagtcg acccagcgcg
1987861 cggtggccaa ctcgacatcc tcgatggacc gccagggctt gccgggtttg atcagctcgg
1987921 tcttgtatag gccgttgatc gtctcggcta gtgcattgtc ataggagctt ccgaccgctc
1987981 cgaccgacgg ttggatgcct gcctcggcga gccgctcgct gaaccggatc gatgtgtact
1988041 gagatcccct atccgtatgg tggataacgt ctttcaggtc gagtacgcct tcttgttggc
1988101 gggtccagat ggcttgctcg atcgcgtcga ggaccatgga ggtggccatc gtggaagcga
1988161 cccgccagcc caggatcctg cgagcgtagg cgtcggtgac aaaggccacg taggcgaacc
1988221 ctgcccaggt cgacacatag gtgaggtctg ctacccacag ccggttaggt gctggtggtc
1988281 cgaagcggcg ctggacgaga tcggcgggac gggctgtggc cggatcagcg atcgtggtcc
1988341 tgcgggcttt gccgcgggtg gtcccggaca ggccgagttt ggtcatcagc cgttcgacgg
1988401 tgcatctggc cacctcgatg ccctcacggt tcagggttag ccacactttg cgggcaccgt
1988461 aaacaccgta gttggcggcg tggacgcggc tgatgtgctc cttgagttcg ccatcgcgca
1988521 gctcgcggcg gctgggctcc cggttgatgt ggtcgtagta ggtcgatggg gcgatcggca
1988581 cacccagctc ggtcagctgt gtgcagatcg actcgacacc ccaccgcaaa ccatcggggc
1988641 cctcgcggtg gccctgatga tcggcgatga accgggtaat tagcgtgctg gccggtcgag
1988701 ctcggccgcg aagaaagccg acgcggtctt taaaatcgcg ttcgcccttc gcaattcggc
1988761 gttgtcccgc cgcaagcgct tcagctcagc ggattcttcg gtcgtggtcc cgggccgtgc
1988821 gccggcatcg acctgcgcct ggcgcaccca cttacgcacc gtctccgcgc agccaacacc
1988881 aagtagacgg gcgacctcac tgatcgctgc ccactccgaa tcgtgctgac cgcggatctc
1988941 tgcgaccatc cgcaccgccc gctcacgcag ctccggcggg tacctcctcg atgaaccacc
1989001 tgacatgacc ccatcctttc caagaactgg agtctccgga catgccgggg cggttcagag
1989061 aggacttcat cgatgcgctg cgttccaaga ttggcgagaa gtctatgggc gtttatgggg
1989121 tcgactaccc ggcgaccacg gatttcccga cagcgatggc cggtatttac gacgcgggca
1989181 cccatgtcga acagacggcg gcgaactgtc cccaaagcaa gctggtgctc ggcggatttt
1989241 cccaaggtgc ggccgtgatg ggctttgtta ccgcggcggc gattccggat ggggcgccgt
1989301 tggacgcgcc caggccgatg ccgcccgaag tcgccgacca cgtggccgcc gtcacactct
1989361 tcggaatgcc ctcggttgcg ttcatgcact cgatcggcgc gccgccgatc gtcatcggtc
1989421 cgctatatgc agaaaagacc atccagctgt gcgccccggg cgaccccgtc tgttctagcg
1989481 gaggcaattg ggcggcgcat aacgggtacg ccgacgacgg catggtcgag caggccgcag
1989541 tgtttgccgc cggtcggctc ggttaaggca gtgtcagcca ctcgccactc agcccgacac
1989601 cgatcggacg tcgtgaccgg cgggaccgag aactgctcga tccgcaacaa cgccgcgacg
1989661 tggattgtgt cccatggtga gctgtgactt ggagtgcggg tggtgagctg aaggcccgtt
1989721 gtcgaccgaa acggggcgac gtccgcgact tcctgtacaa cctgatgctc tgggatttgg
1989781 gctgcggatg cgcggcgggg gttcgctctg gtgtcgtcgg tgttccgccg cgctacgtca
1989841 agccgtgctg cccatcccgg ccgagtacca gcccaccggc gccgccggca cccgccgtgc
1989901 ccccggcttt tccggcattg ccgccgttgc cgccgttgcc gatcaccacg gcgttgccgc
1989961 cggctccacc cttgccgctg gtggcgccat ccccgccggc gccaccgtca ccgccgttgc
1990021 cgtacagccc ggccttgccg ccggcgccgc cgttcccgcc ggcgccggta tcgctggcgc
1990081 cgccggcgcc gccggcgccg ccgaagccgc tgcgaaggcc ggtgatttgg ccggccccac
1990141 cggtgccgcc atcaccgcca gtgccattga ggctgtagcc cccgttgccg ccggccccgc
1990201 cggagccgta gaacaatccc gcgctgccgc cggcgccgcc agcaccggcc ttgcctgaca
1990261 ggctggagcc gccgctgccg ccggcaccgc ccgacgcatt gagggtgagc gagccagcat
1990321 tgccgcctac accgccaccc ccgccggcca tgcccccatg accgccggcc ccgccagagc
1990381 cgccggcacc gtacagccca ccgggcccgc cggcaccgcc tgtccctccg gcccccgtgg
1990441 agccgccgtt cccacctggt ccgccggttc ccccgtgggc gtacagcccg ccggccccgc
1990501 cggccccgcc ggcgcccccg gcggtgctgc cggtcccgcc ggcgccgccg gcccccccgt
1990561 tggcgaacaa cccggcagcg ccgccagtcc cgccggcgcc gccagtggta acgcctgcgg
1990621 tgaaagcgcc gccgccacac ccgccgagcc cagccgcgcc gatgagcaag ccggcgttcc
1990681 cgccggcccc gccgacgccg ccggtggtgg tggcggcccc gccgacacca ccggtaccgc
1990741 cggaaccgat caagaaggcg gatccgccgg cgccaccggc cccgccggca cccgccgttc
1990801 cgacgccgcc ggccccgccg gcgccaccgg tgccaaacag gatcccgcct gccccaccgg
1990861 cgccgcccgc gctgccgttg gtgccggccg caccggcccc gccgttgccg ccgttgccga
1990921 acaaccagcc gccggcaccg ccatcgtccc cggttcccgg cgtcccactg tcgccgttac
1990981 cgatcagcgg gcgtccggtc aatgcctcgg tgggttcgtt gatgaaactg agaatgtcct
1991041 gctgcaggtt gtgccatggc gaggtgctct cgggagcgtt atatccgtcg gcgcccagca
1991101 gcaacccgcc gaagccgccg aagccggact tgccggcgag cgcgccgatg ccgccctcgc
1991161 cgccgttgcc gatcagcacg gcatttccac cggccccgcc gacaccaccg gtgccgccac
1991221 tctcgccgcc gttgccgccg ttgccgccgt tgccgatcaa cccgggcgcc ccacccgccc
1991281 cacccgcccc acctgcggcg gtgcccgcgg ggcccccaga gccgccagca ccgccggagc
1991341 cgccggagcc gctgagcatg ccggcgctgc cgccgacccc accctgcccg ccggcggcga
1991401 agccgaaccc gccggtgccg ccacccccgc cggagccgaa gagcatgccg gcgttaccgc
1991461 cggctccgcc ggcgccgccc ttaccaccac cgaagacagt gccgccagcc ccaccggtgc
1991521 cgccggcgcc accggcggca cccagggaaa gcgtcccggc gttaccaccg ttaccggcag
1991581 cgccgccggt ggtcagtcct gacccgcctg ccccgccgtc cccgccggcg ccgaacaaac
1991641 cgccgccccc accgtccccg ccggccccgc cggtgccgag cgttccgtga tccccgaatc
1991701 cgcccgcccc gcccatgccg ccggcaccaa acaacccgcc ggccccgccg gcgccgcccg
1991761 ccccgcccgt gtgaccctgc ccaccggcgc cgccgacacc gccggtggtg aacagcccac
1991821 cggccccgcc ggcgccgcca gccccaccgg cagtgctgaa gctgaacccg ccggcaccgc
1991881 cggccccggc ggcgccggcg agcataccgg cgttgccgcc ggttccgccg gtaccgccga
1991941 tgccaccgac aagagacgtc gcagccccgc cggcgccgcc ggcgccgccg gccccaaaca
1992001 gcatggcgga cccgccagcg ccaccggccc cgccgatccc gttgttggcg gtggcggttc
1992061 cgccggcacc gccggccccg ccgttgccga acagcccggc ggccccacca gggccaccag
1992121 ccccgccgtt ggcgcccttt gcaccggatc cgccggcgcc accgttgccg atcaaccagc
1992181 cggcatcccc tccgttggcc ccggtgccgg gagcaccgtt agccccgtta ccgatcagcg
1992241 gacggccggt agcggccagg acgggcgcgt tgatcgagtt gagcagcggc gtcacggcgg
1992301 cggcctcggc ggccgcatag gcgccccccc cggtggtcag cgcctgcacg aaccgaccat
1992361 gaaacgccgc cgcctcggcg ctcgccgcct gataggcccg gccgtgcgcg ccgaacaacg
1992421 cagcgattgc cgccgagatc tcatcggcac cggcggccag caggctcgtc gtgttggccg
1992481 ccgcagccgc gttggcccca gcgatcgtcg agccgagatc ggctagatcc gtcgccgccg
1992541 ccgcgatagt ctccggcacc gcgatcacaa acgacatctg aaaacctccc acgaccgctg
1992601 accaccaggt aatgccgacg acccaggaag cctcggcgcc gggtgaatcg gtgccaatca
1992661 gcgtatgggc gggcaggcga cccaaccggt gttccagccc gactcatacc cgctgtcaaa
1992721 tgacctgaca atcactcggt ggtcacacgc tgcgtgcttc acattggtag cttgggcacg
1992781 tcggcaaccg tcacagctgt cacacgggtc cctgtggggt tggtcggcca ccggcgacaa
1992841 cgtttcctgc gcgccttgat ctgtcgccgc tgggcaggca tcgccgcgac ggccgtatca
1992901 ggcttggtcg gtgtgagccg ccaaatcggt attgacgaat tcgtcatcga actcccggcc
1992961 aagaccactt aggtctgatg gcctggttct cgtcctcaag ccgcgttagc accacttcgg
1993021 gacgccacgc ggttcagccc gttctcctcg aatagcagcc tgccggtgcc accggcgtct
1993081 gggcacccca gactttcgcg ccgctgtcac ccgttgcgaa ggcccccgca atggcacggt
1993141 caccgacatg tgatgccgag gggctgcgcc ggggctagat tcgcgtgcaa tgcgtgccta
1993201 aactttttgg cggggttggg gatttctgaa ccgatcagtc ccgggtgggc ggctatggag
1993261 cgactaagcg gactcgatgc tttcttcctc tatatggaga caccgtcgca gccgctgaac
1993321 gtgtgctgcg tcttggagtt ggacacctcg acgatgccgg gcggctacac gtacggccgg
1993381 tttcatgccg cgttggagaa gtatgtcaag gcggcgcccg aatttcggat gaagctcgcc
1993441 gataccgagc ttaacctgga tcaccccgtg tgggtggacg acgacaattt tcagatccgg
1993501 caccacctgc gccgggtcgc tatgcccgcg cccggagggc gtcgcgagct ggccgagatc
1993561 tgtgggtaca tcgccgggtt gccgctggac cgtgaccgcc cgctgtggga gatgtgggtc
1993621 atcgaaggcg gtgcccgtag cgacaccgtg gcggtgatgc tcaaggtcca ccacgccgtg
1993681 gtcgacggtg tcgccggtgc gaacctgctg tcccacctgt gcagcctgca gcccgatgcg
1993741 ccggcaccgc aacctgtccg gggcaccggt ggcggcaatg tgctgcagat agctgcgagt
1993801 gggctggagg ggttcgcgtc gcggccagtg cggctggcga cggtggtacc ggcgacagtg
1993861 ctcacattgg tgcgcacatt gctgcgtgcc cgtgagggcc gtaccatggc cgccccgttt
1993921 tcggccccac cgactccgtt caacggcccc ctcggtcggc tgcgcaacat cgcgtataca
1993981 cagctcgaca tgcgcgacgt caagcgtgtc aaggaccggt ttggggtgac catcaacgat
1994041 gtggtggtgg cgttgtgtgc cggagcgcta cggcgcttcc tactcgagca cggcgtgctg
1994101 cccgaggccc cgttggtggc caccgtgccg gtttcggtac acgacaagtc ggaccgaccc
1994161 gggcgcaacc aggccacctg gatgttctgt cgggtaccga gccagatcag cgaccccgcc
1994221 cagcgcatcc gcaccatcgc cgccggaaac accgtcgcta aagaccacgc cgcggccatc
1994281 ggccccaccc tgctgcacga ctggattcag ttcggcggct cgacgatgtt cggagcggcc
1994341 atgcggatct tgccgcacat ttcgataacg catagccccg cctacaatct gatcctgtcg
1994401 aatgtgcccg gaccccaggc ccagttgtac tttctgggtt gccgaatgga ctcgatgttt
1994461 cccctcggcc ccctccttgg caacgcgggc ctcaacatca ccgtcatgtc cctcaacggg
1994521 gaactgggtg tcggcattgt ctcctgcccc gacctgctgc cggacctgtg gggcgtggca
1994581 gacgggtttc ccgaggcgct caaagagctg ctggagtgca gtgatgacca gccggaaggc
1994641 agcaaccacc aggactcctg agtcgtacgt tcagaaccgg tagtcggtgc cggtgcccag
1994701 aacttcgatg gctgcgttga tgttcgggat cactgtggcg ccgtatcggc tgacgatctg
1994761 cccaagcgcg cgagcaaggt gcggacccac ggcctcggcg atgagggcgt cctcggcgat
1994821 gacgatgccg ttcaccatgt gggcagcgag cagccggccg tcgtgggcga cctcgtaacg
1994881 ccagtcaccg atctggattc gctcgggatt agaccgaaaa aagccacgtc gtgcgggggt
1994941 atgaatcact cccggaagtc cggcgaacac tttgaccacc aacgcgacac cgccgggacc
1995001 gacgagcgcg gccgcgacgg cgcggctcac tcgctcggta tcgaaatcag acatcagctg
1995061 tccatcggca ggacgaatga cggtgtgatc gtttccccgc tgccggtgcg gcgcacggcg
1995121 gttcccgcgg tgtagaactc caccgtgtgc actccccacg cgtagttcga gatggcgaag
1995181 tgcacgccca ccacgccggt tgcgccgtct cgctcggcct cgctctgcat gcgtgacatt
1995241 gccagctcac gcgcttggta gttgccttgc gtccactgtg gcatctccat gttgcggccg
1995301 atctggcgaa gcgtttgcat gaatccctgc acggcgatgt ggaatacgca attgcccatc
1995361 acgaacgcca ccggcgcaaa cccggatcgc agcagcgtca ccatgtcctg gccggataga
1995421 tgactggaga atgcttggcc gttgggacgc cgaaatgctc cgggcttggc ggtgtatcgc
1995481 actgcggtac cgaccgccat gaactcaagg tgttccccgc cctccccatg gtggcgccag
1995541 ttgagccgga caccgacgat cccgtccgct ttgagggcat cggcttcggc ctgcatgcgc
1995601 gccatcgcat tccagcgcgc ccggtatgtc gcctcggtga ggacacccag ttcctgttgc
1995661 tgcctcatgc cgctgaattg gaagccgacg tgatagaccg agacacccat gaccagctcg
1995721 atgggctcaa acccggcccc atgcagcaat gcgaactcgt tgatcgacaa gtcggacgtg
1995781 aatgacttct cagcgtgcga cagccgttcg ctggctactg gatcgagcga gcttgattgc
1995841 atcgttgtgc gtccttcctg tggtgtgtgt cagcgtacga cgcgcaaacc atgcagcgtc
1995901 tgccatcagc gtccccaggg catcggcggc gtcttggcgc cggcaacgct gttgtctggc
1995961 agtcgcgccg gggagtcgac gctaccggtc ggcaccgcgc cggccgcgca tgagtgaggt
1996021 ggcagcgcgt aacgcgccgc gtagtgcgta gacggcagtc accgccgcca acaggatcaa
1996081 caggacaaag gtcggcaacc tgaaccgccc cggcatgtcc ggagactcca gttcttggaa
1996141 aggatggggt catgtcaggt ggttcatcga ggaggtaccc gccggagctg cgtgagcggg
1996201 cggtgcggat ggtcgcagag atccgcggtc agcacgattc ggagtgggca gcgatcagtg
1996261 aggtcgcccg tctacttggt gttggctgcg cggagacggt gcgtaagtgg gtgcgccagg
1996321 cgcaggtcga tgccggcgca cggcccggga ccacgaccga agaatccgct gagctgaagc
1996381 gcttgcggcg ggacaacgcc gaattgcgaa gggcgaacgc gattttaaag accgcgtcgg
1996441 ctttcttcgc ggccgagctc gaccggccag cacgctaatt acccggttca tcgccgatca
1996501 tcagggccac cgcgagggcc ccgatggttt gcggtggggt gtcgagtcga tctgcacaca
1996561 gctgaccgag ctgggtgtgc cgatcgcccc atcgacctac tacgaccaca tcaaccggga
1996621 gcccagccgc cgcgagctgc gcgatggcga actcaaggag cacatcagcc gcgtccacgc
1996681 cgccaactac ggtgtttacg gtgcccgcaa agtgtggcta accctgaacc gtgagggcat
1996741 cgaggtggcc agatgcaccg tcgaacggct gatgaccaaa ctcggcctgt ccgggaccac
1996801 ccgcggcaaa gcccgcagga ccacgatcgc tgatccggcc acagcccgtc ccgccgatct
1996861 cgtccagcgc cgcttcggac caccagcacc taaccggctg tgggtagcag acctcaccta
1996921 tgtgtcgacc tgggcagggt tcgcctacgt ggcctttgtc accgacgcct acgctcgcag
1996981 gatcctgggc tggcgggtcg cttccacgat ggccacctcc atggtcctcg acgcgatcga
1997041 gcaagccatc tggacccgcc aacaagaagg cgtactcgac ctgaaagacg ttatccacca
1997101 tacggatagg ggatctcagt acacatcgat ccggttcagc gagcggctcg ccgaggcagg
1997161 catccaaccg tcggtcggag cggtcggaag ctcctatgac aatgcactag ccgagacgat
1997221 caacggccta tacaagaccg agctgatcaa acccggcaag ccctggcggt ccatcgagga
1997281 tgtcgagttg gccaccgcgc gctgggtcga ctggttcaac catcgccgcc tctaccagta
1997341 ctgcggcgac gtcccgccgg tcgaactcga ggctgcctac tacgctcaac gccagagacc
1997401 agccgccggc tgaggtctca gatcagagag tctccggact caccggggcg gttcaggccc
1997461 cgatggtgtg cccggtggtg atacgggcac accagcacca ggttggccag ctcggtggcc
1997521 ccaccgtcct gccaatgtcg gatgtggtgg gcgtgcaaac cccgggtggc cccacaaccg
1997581 ggaaccacac acgtgcggtc gcgatgctca agcgcacgac gcaaccgacg attgatctga
1997641 cgagtcgttc gaccgcagcc aatgacctgc ccgtcacgtt caaaccaggc ctcaaaggtg
1997701 gcatcacaga gcagatatcg gcgttcggac tcgctgagca gcggacccag gtgcaggcca
1997761 gcggcacgct cctgcacgtc tagatgcatc accacggtgg tgtgctgccc atgtggccga
1997821 cgagccacct cggcgtccca gccggcctca accagacgca gaaacgcctc aacattgccc
1997881 ggcaacgggg gccgctgatc cgacacaccg tcgctgttgt cgtgatcacg cttgtactcg
1997941 gcgatcaacg catccagatg agactgcaac gccgcatcga acttcgccgc ctccacgtgc
1998001 ggaagcttga ttcgccaaca actgaactgc tcatcggcgc tcctggtgat cgagggccgc
1998061 ggttccggcc gaaaatccgg ttcgggttcg ggtcgcggtt ccaacttgag cgcggtccgc
1998121 agctgattca ccgtggcaac gccggccaac tgcgcataat gcgcatccga accctcaccc
1998181 gcccgccccg cgatcacccc aacctgatcc aacgacaacc gcccctcccg cataccccgg
1998241 gcgcagcgcg gaaactccgg caaccgccgc gccaccgtgg cgatcgtgtg ggcgttgcct
1998301 gacgagcagc ccatcttcca ggccaccaac cccgccaccg accgcgcccc cgtcacaccc
1998361 cacaacccgt cgcgatccag ctcagccacg atctccacaa tgcgcccatc aatcgcattg
1998421 cgctgaccgg ccaactccgc caactcctca aacaacacct ccacacgctc ggcaggactg
1998481 actaccgctg cgccagacgt cgcggtcgag gacatgagtt catcatcgca gcagggtctg
1998541 acaactccgg ccaacccgaa tccacgcccg gggccgtgcc gtcatcaccc cgcaaagaga
1998601 tgctcggctc cgccggtacg ggcaccccac gatccaacac cgcctgctca gccgccgacc
1998661 actcaacaac cacaaccgtc aatgcagtta acccggcccc accacggccc caactacggc
1998721 gctcgatcca gcgcgatcca acaacaccaa aaccacacga tccgcaccgc actcgccccc
1998781 cgaaacggtc ctcacgatgc ccacgatggc cacctgaact atcccaggct ttgttcctag
1998841 tcggtgcgag ggccggggtt ggctggctcg cggggtgtga ggtgccggtg agggcggcct
1998901 cgtactcggc ctggactccg gtagcctagg gcttcgtgca ggcattcctg gttgtaccag
1998961 ccagccattc ggcggttgcc agtttgacgt cgtcgatgca ccgccagggt ctgccgcggt
1999021 tgatcaactc ggacttggag gcgacgttga ccgcgagggc gttgtcataa cagtcgccac
1999081 gagacccgac cgaaggggcg atcccgagct cagccagtcg gtcggtatag gtcagcgata
1999141 gttactgcga tccggggtcg gaatgatgca ccaactcaga aagatctgaa tttgattgcc
1999201 aaacagcatg attgaatact tgtacgggca gatcttcggt gcgcatcgtc gccgagacgg
1999261 cccaaacgac gatctttcgg gtgcacacgt cggtgacgaa cgcggtgtag cagaacccct
1999321 gccaggtccg cacgaacgtg atgtcggcga cccacaaccg gttgggctta ctgccttgaa
1999381 ttgccggttt accagatcag ccggccgtgg tcggctacgt cggtgacggt ggtgaacacg
1999441 gccgttgcac gccgcacagc ccggccttgc gcatcaacgg gcgggtttgt tctctgccga
1999501 ggtgccaacc cttgcgtttc atggcctggt gcatcttgtt aatcccgtag accgagtagt
1999561 tgtcgcggtg cgccgtgcgt aggcgaactt gagactatga ctgtgttttc cggccagtcg
1999621 gatgcgccct ggcatggccg gcggtaggag atccaatcgt gcattgtttt cgtgcagcca
1999681 tccaataccc ccctgggtac tatggcggtg ccacttcaac gagatagagg gtgcatgtga
1999741 ttggtgatca agacagcatc gccgcggttc tcaacaggtt acgccgtgct cagggacagc
1999801 ttgccggggt gatttcgatg atcgagcagg gccgcgactg ccgggacgtg gtcacccagc
1999861 tcgccgcggt atcgcgcgca ctcgaccgcg ccggattcaa gatcgttgcg gcagggttga
1999921 aggaatgcgt gtccggggcc acggccagcg gcgcggcacc gctgagtgca gctgagctag
1999981 aaaagctgtt cctggcgctc gcttgaatgg gcccgaagcc atcaataacc aaggccgccg
2000041 tccgtgtata cccatagggg tatattggac gccatgtcgg accagccacg tcatcaccag
2000101 gtcctcgacg acctgctgcc ccaacaccgc gctctacgtc accagattcc ccaggtgtac
2000161 cagcgatttg tagccctggg cgacgccgcg cttaccgacg gcgctctcag ccgcaaggtc
2000221 aaggagcttg tggcgctggc gatcgcggtt gtgcaggggt gcgatggctg cgtcgcatca
2000281 cacgcccaag ccgcggtacg ggccggcgct acagcgcaag aagccgctga ggccatcggg
2000341 gtcaccatct tgatgcacgg tggaccggcc accatccacg gtgctcgtgc ctacgcggca
2000401 ttttgcgaat tcgctgacac aacgccgtcc tagtcgtcgc ggccaccgag cggaccgcgc
2000461 tgacccgggc tgaaacgttc cgaggcggac tggcgaaacg catggtaggt cacgcggaaa
2000521 tgcggggcgt gttggcgcga tggcgatagc ctttgccgag ggttcaatgg tgaccgggcg
2000581 cccgccgggt ttccatgagg cgggaggtcc ctgatgtcct atctcgtcgt ggtgccggag
2000641 ttggtcgcag cggcggcaac agatttggcg aacatcggtt cgtcgattag tgcagccaac
2000701 gcggccgcgg cggcaccgac cacggcactg gtcgcagccg gcggcgacga ggtatcggcg
2000761 gccatagccg cgttgttcgg agcgcatgct cgggcatatc aagcgttgag tgcccaggcg
2000821 gcgatgtttc atgaacagtt tgtccgggcc ctcgccgccg gcggtaactc ctacgccgtc
2000881 gctgaggcgg caaccgcgca atcggttcag caagatctgc tcaacctgat caatgcgccc
2000941 acccaggcgc tgttggggcg tccgctgatc ggcaacggcg ccaacgggct gccgggtacg
2001001 ggccagaacg gcggcgacgg cgggattctg tacggcaacg gcggcaacgg tgggtccggc
2001061 ggggtcaacc aggccggtgg caatggcggg aatgctgggc tgtggggcaa tggcggatcc
2001121 ggcggagccg gcgggaacgc caccactgcc ggccgcaacg gcttcaacgg gggcgccggg
2001181 ggaagcggcg gtttgctgtg gggcaatggc ggtgccggcg gggccggtgg gaacggcggt
2001241 ccggctccgc tcgtgggcgg ggtgggcacc accggtggcg ccggcgggaa cggcggcggc
2001301 gccgggttgt tctacggttt cggcggcgcc ggtgggaacg gcgggatggg cggggtggca
2001361 ccgagcaccg gcccctcgat gggcatcctc ccggccggcg gtgtcggcgg gcctggtggc
2001421 tccggcgggg cgagcgcgct tgccttcggc tccggcggcg tcggcggtgc cggtggcttg
2001481 ggcgggccga ccgatggcac cgtccagggg gtgggcggct tcggcggtca gggcggcaac
2001541 ggcgggcaga gcggcttgtt gtttggcaac gcgggagccg gcggggcagg cgctgccggc
2001601 ggagccggca ccggcgacac cgagagcttc ggcggccacg gcggggccgg cggtgatggc
2001661 ggcgctgttg gcttgatcgg taacggcggg gccggcggca ccggatctcc cggcgctgtg
2001721 gtgggtggta acggcggcgt cggtggtctg ggtggcgccg gcagtcccgg gggtctgttg
2001781 tacggcaccg ggggggccgg cggcaatggc ggaccgggtg gtgacggtgg tactggcgcg
2001841 acggtgggct ttgccggctc cggcggtttc ggcggtgcgg ggggcatcgc ccagctgttt
2001901 ggcacgggtg gcatgggtgg tagcggcggt ggtataggcg ctggcaccac gaccgtggtg
2001961 ccgcccgacg tcgccccggt gggtggcaca ggcggcaatg gcggtcgcgc cgggctgctg
2002021 ttgggtgtgg gtggcatggg cggtaatggc ggtgccacca gcgtcggcgg gacgctctac
2002081 gccgccggtg gaaacggcgg cgacggcggg ttggtgtggg gcaacggtgg caccggcggg
2002141 agcggtggcg ccggcggggc gggcagcgtc ggcaacggcg gtgcgggtgg caacgcggca
2002201 ctgctgttcg gcaacggcgg ggcgggcggg gccggcggcg ccggcggcat cggtgccggc
2002261 ggagccggcg gcttcggcgc ggttctgttt ggcaacggcg gggctggcgg gagcggtgcc
2002321 cccggtggca tcggcgccgg tggcaatggc ggaaacgcgc tgctggtcgg caacggcggc
2002381 aacggtgggg caggtaccgg tggggctgct ggcggtgccg gtggctcggg cgggttgcta
2002441 ttcggccaaa atgggatgcc cgggccgtga gcgccccaac ccaggccaac cccctatggg
2002501 caatctgcac atcaattggc caggtcgaca gcagaccgca cacatctacg agattggttc
2002561 ccgatccgtg ggtggggccg ggaaaagcgg ctgtaagagt tggctaggtt cagtagggtg
2002621 gcggcgtgca tgaggtggct gctcgtgagc aacgttcgga cgggccgatg aggctggatg
2002681 cgcagggccg actgcagcgt tacgaggagg cgttcgctga ctacgatgca ccgtttgcgt
2002741 tcgtagatct cgacgcgatg tggggcaatg ccgatcaact gcttgcgcgc gccggcgaca
2002801 agccgatccg ggtggcgtcg aagtcgctgc gttgccgacc actgcaacgc gaaatccttg
2002861 atgccagtga gcgattcgac gggctattga cgttcacgct taccgagacg ctgtggcttg
2002921 ccggccaagg tttctcgaac ctgttgttgg cctacccgcc gaccgaccgg gcggcattgc
2002981 gtgcgcttgg cgagctgacg gccaaggacc cggacggggc gccgatcgtg atggtggaca
2003041 gcgtggagca ccttgacctg atcgagcgca cgaccgacaa gccggtacgg ctgtgtctgg
2003101 atttcgatgc cggctattgg cgcgccggcg ggcggataaa aattggttcc aagcgctcgc
2003161 cgctgcacac cccggagcag gctcgcgcac tcgcggtgga gatcgcgcgg cggccggcgc
2003221 taacgttggc ggcgttgatg tgctacgagg cccacattgc gggcctcggt gacaacgtcg
2003281 ccggcaagcg ggtccacaac gcgatcatcc gtcggatgca gcgcatgtcg ttcgaagagc
2003341 tgcgcgagcg tcgtgcccgg gccgtcgagc tggtgcgcga ggtcgccgac atcaagatcg
2003401 tcaacgccgg tggcaccggc gacttgcagc tggttgcgca ggagccgttg attaccgaag
2003461 cgaccgccgg ctcgggtttt tacgcgccga cactgttcga ctcgtattcg acgttcacgc
2003521 tgcagcccgc ggcgatgttc gcgctgccgg tatgccgtcg tcccggtgca aagaccgtga
2003581 ccgcgctcgg gggtggctat ttagccagcg gggtcggggc gaaggaccgc atgccgactc
2003641 cctacctgcc ggtcgggctg aagctcaatg cgctggaggg aacgggcgaa gttcagacac
2003701 cgctatccgg tgatgcagcc cgacggctga agcttggcga caaggtctac ttccgccaca
2003761 ccaaggccgg tgagctgtgt gagcggttcg accatctgca tctggtccgt ggcgctgaag
2003821 tagtcgacac cgtccccacc taccggggtg aagggcgcac cttcctctaa tgctgaaatg
2003881 gacgaggccc acccggctca cccggcagat gcggggcggc ccggtggccc aattcaaggc
2003941 gcgcgaagag gagctgccat gacaccgatc accgccctgc cgaccgagtt ggcggccatg
2004001 cgcgaggtag tcgagacgct cgcacccatt gagcgtgccg cgggcgagcc gggtgagcac
2004061 aaggcggccg agtggatcgt cgagcgcctg cgcacggcgg gcgcgcagga cgcgcgcatc
2004121 gaggaggagc agtacctcga cggctacccg aggctgcacc tcaagctgtc ggtgatcggg
2004181 gtggcggccg gcgtcgcggg cctgctcagc agacgtttgc gcatccccgc cgcgctggcc
2004241 ggggtgggtg cggggctggc aatcgccgac gattgcgcca acgggccgcg cattgtgcgc
2004301 aaacgaacgg agacgccccg gacgacatgg aacgcggtag ccgaggccgg tgatcctgct
2004361 ggtcagctaa cagttgttgt gtgcgctcac cacgacgccg cgcacagcgg caagtttttc
2004421 gaggctcata ttgaggaggt aatggtcgag ctgtttcccg ggattgtgga gcgcatcgac
2004481 acgcagctgc cgaactggtg ggggccgatc ctcgcgcccg cactcgccgg tgtcggcgcc
2004541 ctgcgcggca gccggccgat gatgatcgcc ggaacggtgg gtagcgccct ggccgccgct
2004601 ttgttcgccg acatcgcgcg cagtccggtc gtccccggtg ccaacgacaa tctctccgcg
2004661 gttgcgctgc tggtcgcgct ggccgagcgg ctgcgcgagc ggccggtgaa gggcgtgcga
2004721 gtgttgctcg tgtccctggg ggccgaggaa acgttgcagg gcgggatcta cgggttcctg
2004781 gcgcgacaca aacccgagct ggaccgcgac cgcacatact tcctgaactt cgacaccatc
2004841 ggctcacccg agctcatcat gctcgagggc gagggcccga cggtcatgga ggactacttc
2004901 tatcggccat tccgggatct ggtcatccgg gcggccgagc gcgccgacgc gccgctgcgg
2004961 cgcggcatcc ggtcgcgcaa cagtaccgac gcggtgttga tgagccgcgc cggctacccg
2005021 accgcgtgct ttgtgtcgat caaccggcac aagtcggtgg ccaattacca cctgatgtcc
2005081 gatacacctg agaatctctg ctatgagacg gtgtcccacg ccgtcaccgt cgccgaatcc
2005141 gtgatcaggg agctggcccg atgagcccga tatggagtaa ttggcctggt gagcaagtct
2005201 gcgcgccgtc ggcgatcgta cggccgacct cggaggctga gctggccgac gtgatcgcgc
2005261 aggcggcgaa aagaggcgag cgggtacgcg cggttggcag cgggcattcg tttaccgaca
2005321 tcgcctgcac ggacggggtc atgatcgaca tgaccggcct gcagcgggtc ctcgacgtgg
2005381 accagccgac tggcctggtg acggtcgagg ggggcgcaaa gctacgtgcg ctgggacccc
2005441 aattggcgca acgacggctc ggcctggaga accagggtga cgtggatccc caatccatca
2005501 ccggcgcgac cgcgaccgcg acgcacggaa ccggggtgcg tttccagaat ctgtcggcgc
2005561 ggatcgtttc gctgcggctg gtcaccgcgg gcggggaagt gctcagtctg tccgaaggtg
2005621 acgattacct ggcggcacgg gtttccctcg gcgcgctagg agtgatctca caggtcaccc
2005681 tgcagacggt tccgctattc acgttgcatc gccatgatca gcgacgctcg ctggcgcaga
2005741 cgctggagcg cctcgacgag ttcgtggacg gtaatgacca tttcgagttt ttcgtattcc
2005801 cttacgcaga taaggcgttg acgcgcacca tgcatcgcag tgacgagcag cccaaaccca
2005861 cgcccgggtg gcagcgcatg gtcggcgaga acttcgagaa cgggggattg agcctgatct
2005921 gccagaccgg ccgtcgtttt cctagtgtgg cgccgcgact gaaccgcctg atgacgaaca
2005981 tgatgtcgtc ctccaccgtg caagaccgcg cctacaaggt ctttgcgacc caacgcaagg
2006041 tcaggttcac cgagatggag tacgcgatcc cgcgtgaaaa cgggcgcgag gcgctccagc
2006101 gtgtcatcga ccttgtgcgc cgtcgcagct tgccgatcat gtttccgatt gaggtgcgat
2006161 tctccgcccc cgacgattcc ttcctgtcga ccgcatatgg gcgcgacact tgctacatcg
2006221 cggttcatca atacgccggt atggagttcg aaagctactt ccgcgccgtc gaggagatca
2006281 tggacgacta cgccggtcgg ccacactggg gtaaacgtca ctatcagacc gccgccacgc
2006341 ttcgtgagcg ctatccgcag tgggatcggt tcgccgcggt tcgcgatcgc ctcgatccgg
2006401 accgggtgtt tctcaacgac tacacccggc gcgttctcgg tccctgacaa cgaatcaacg
2006461 aaccctcgtg gtgttcggcc gatatcgaca cggtcacaac cgcgtaccga tatcagcggt
2006521 ggtatggcgt aacgggcacg atgcacaaat catggcagca tgcgcgttgg gagccaccgt
2006581 cgcgaaccaa gcgtgcgcgt tcacggattc gtccgcctga gttggcggat atcggttggg
2006641 ttcaacagga ggtagccaac ccatgacggc gaatcgaggg cccgctgcaa tctcgagcgg
2006701 ctcgaactct ggccgcgttc tcgacaccgc ccggggtatc ctcatcgctc ttcggcggtg
2006761 ccccgcagag accgcgttcg acgagttgca caacgccgct caacggcaca gattgccggt
2006821 cttcgaaata gcttgggcac tagtgcattt ggcggtcgag ggaagcacgc catgccggag
2006881 cttcgtcgat gcccagtcgg cggctcggcg ggagtggggt cagctttttg cgcatgcggc
2006941 ggcgtaatgc cagcttggcg gtggtgtggg gaagcaccgc cgccagctaa acggatcggc
2007001 ttcgaatcca ggagcccaat cagcgagtcc agtccggcga gtccgcggcg gcgcgcaacg
2007061 cggcgattat gcgctgctct ttttccagaa atcgtgcggt gggcgccggc accgagatcg
2007121 cgatcacgtt gtcgcccagg gcgcgtcgtg cgatcgcagc cgcggatatc cctggggtgt
2007181 gctcgttgcg gtcgaaagcg ataccggtgc gccggatctc gacgatctcg cgccgtagac
2007241 cttcggccac catgggatcc agacggcaga gcgcggcctc ggcgtcggcg tcgtcgagag
2007301 cagccagcgc cgcttttcca ttcgcggttc cgttcaacgg gaagcggagc ccgacggctg
2007361 agaccgcacg cagccggtaa gacgattcga tctggtcgac aaaccacatt cgctggccgc
2007421 gcagtaccga caggtcgacc gtttcgccgt cggtcgcgcg ggcaactcgc tcgacggtcg
2007481 gccggaacgc cgcggctatg tgggctccgg tgacacttcc gaatcccagc aaacgctcgc
2007541 ccagtgcgaa gcggccgtgc gaatcgacac taaccagccc cacctcgacc aggccgacca
2007601 gcaagcgtcg agtcgtcgat ttggccagcc ccagccgctc gcagagatcg actaggcgca
2007661 ggtgtcccgg ttcggcagct atttcgtcca gcgcggcgac ggcgcgacgg agcacctgga
2007721 tgccttcgtc gcgattcgtt gtcgactttc cttccgtagg cggcacaact gcaatatagt
2007781 gaaccgaaat acggatcaca atgattcgaa atacggacca ggagttttgc tatgagggcg
2007841 ctaccggccg ggcggcactt cttccggggc agtgacgggt acgaggcggc tcgccgcggc
2007901 accgtgtggc atcggcgcgt accggatcgc taccccgagg tgatcgttca ggctgtcagt
2007961 gctgacgaca ttgtcagcgc catccgctac gccacggtca atggccataa ggtgagcgtc
2008021 gtgtccggtg ggcacagttt tgccgccagc catctgcgcg atggcgctgt gctgctcgac
2008081 gtgagccgga tagaccacgc ctccatcgac gccgataagg gccgcgcggt cgtcggtcca
2008141 gggaagggcg gcagcgtgct catggccgaa ctggaggcgc agggcctgtt cttcccgggt
2008201 ggccactgca ggggagtctg tctcggaggt tatctgctgc agggcggata cggctggaac
2008261 agccggatct acggcccggc gtgcgagagc gtgattggcc tggacgtcat caccgccgac
2008321 ggcgcgcaga tccattgcga cgcagacaat cacgccgatc tgtactgggc cgcccgcggc
2008381 gccggtccgg gcttttttgg cgtcgtcacc tcgttttacc tgaagctgta tccgaggccg
2008441 gccacctgtg gcaccagcgt ctatgtctac ccattcgacc ttgccgacga ggtctttacc
2008501 tgggcccgcg cggtcagcgc cgaagtcgac cctcgggtcg agctgcaagc ccttgcctcc
2008561 cgcggtgaac cgagcatggg catcgacgtc cccgtcatct cccttgcctc gcccgctttc
2008621 gctgactcgc ccgaagaggc cgaacaggcc ctcgccctgt tcggcacctg cccggttgtc
2008681 gagcaggcac tggtcaaagt cccttatatg ccaaccgatt tgcctgcctg gtatgacgtc
2008741 gcgatgaccc actacctgtc agaccatcac tacgcggtgg acaatatgtg gacgtcggcg
2008801 tccgctgagg acctgctgcc gggtatccgc tcaatcctgg acacgctgcc cccgcatccg
2008861 gcgcacttcc tctggctgaa ctggggtcca tgccctcccc gtcaagacat ggcctatagc
2008921 atcgaagccg acatctactt ggcgctctac ggctcctgga aggatccggc cgacgaggcg
2008981 aagtacgccg actgggcgcg gtcccacatg gccgcgatgt cgcatctggc ggtcggcatc
2009041 cagctcgccg acgagaacct cggtgcgcgt ccggcgcgct tcgccagcga cgcggccatg
2009101 gccaagctcg accgggtgcg cgccgaatac gaccccgacg gtttgttcaa cagttggatg
2009161 ggaagaatct gatggccagc gatctgtacc tgggctaccg caacgacgac gcggacacgc
2009221 cgttcggcaa gttcttcaaa cccgagatgg ccccgctgcc acagcatgtc gtggtggcgt
2009281 tgcagcatgg cccccaggcc gggatggcgt tgctcgcctt cgacgacgcc gcgagcatcg
2009341 ttgatgaggg ctatcagcag accgagaacg gctacgggat tctcggcgac ggcagcatgc
2009401 aggtatccgt gcgcaccgac atgcccgggg tcactcccgc gatgtgggca tggtggttcg
2009461 gctggcacgg cagcgacacc cgccgctaca agctgtggca cccgcgggcc catctatcgg
2009521 cgcggtggaa ggacggcgac caggacagcg gggccggccg tcggggcgcg cagcgttacg
2009581 tcggccgctg gtcgatgatc agcgagtaca tcggctcgac gaaactgggt gccgcaatac
2009641 aattcgtcga gccggcggcc atgggtctgc ccgacgacag cgacgatacg gtgtcgatct
2009701 gtgcgcggtt gggctctgct gacgccccgg tggatgcggg ctggttcgtc catcaggtcc
2009761 gatcgacgcc gggcgggtcc gagatgcggt cacggttttg gatgggcgga ccgcacatcg
2009821 cggtgcgcaa ggcacccgag gtcgcgtcca aggcggtgcg tcccatcgcg tcgaagctaa
2009881 tcggcgtctc ggaatcgacc gcgcgtaatc tgctggtgta ctgcgcgcag gagatgaacc
2009941 acctggcggg gttcttggcg gacctgtggg aaagcttcgg tgacgagtga ggtttcagct
2010001 ttgctcggca aacgctggcg ccacgtattt ttcgaccagc cggcgttcgg cttcgtcgtt
2010061 ctcagctggc caatacatca gtgagagcac cacgcgtacc acccatttcg cgccttgcgg
2010121 atcaccgccg gctatgccgg tgagctcggt agcaaagtcc gcaagcaacg gtgactcggt
2010181 gagccaggcc aattcaccgg cgccaccgtg gatcgagccg aacatgagct tgcccagcgg
2010241 gtcggatcgg attcgctgaa gcgataacag gatcgccgcg acgactcgct cccgcccccg
2010301 cagagtttcg acatccgagc gcacgccgtc ggcgatccgg gccgcggccc gggtcagaac
2010361 gacatcccgg atctgggcct tgccgccggc acggcggtag atggtcgctc gggagcagtg
2010421 gacctcgcgg gctaatttgt cgatgtcgag tgcgttgagc ccgtagcgcg taatgaggtc
2010481 ggttgcggcg gcgtagatcc gttcggcagc gatcgtgcgg cggttgccgc ccacgatcca
2010541 atcgttaccc ggcactggtc aggcgcattt ccatcgagag gcgaagagcg attcttctca
2010601 tagtgagaca caagccttac ttattctcat cgtagttgca ggtccgcctc ccgcggtgag
2010661 acgttcgccg aaaggctccc cgggcgcagt tctcgacttg cagcgacgcg ttgaccaggc
2010721 ggtatccgcc gatcacgctg aactaatgac aattgccaag gatgccaaca cgttctttgg
2010781 tgccgaatcc gtgcaggacc cctacccgct gtatgagcgc atgcgcgccg caggctcggt
2010841 ccaccggatc gctaactcgg acttctatgc cgtgtgcggt tgggacgctg tcaatgaggc
2010901 catcggtcgt ccggaggact tctcctcgaa tttgaccgcc acgatgacct atacggccga
2010961 gggcaccgct aaaccgttcg agatggaccc actcggcgga cccacacacg tgttggccac
2011021 cgccgacgat cctgcccacg ccgtgcaccg caagctcgtg ctgcgtcact tggcggccaa
2011081 gcggatccgc gttatggagc agttcaccgt acaggctgcc gaccggctgt gggtcgacgg
2011141 catgcaggat gggtgcatcg aatggatggg cgccatggcc aatcgcctac cgatgatggt
2011201 cgtagctgag ctcatcggcc tgcccgaccc cgacatcgcc cagctggtga agtggggata
2011261 cgcggccact cagctactcg aagggttggt cgaaaacgat cagctcgtcg ccgcgggtgt
2011321 ggcgttgatg gagctcagcg gttacatctt cgagcagttt gaccgtgccg cggccgatcc
2011381 gcgggacaat ctgctcggtg agcttgccac cgcctgcgca tcgggggagc tggacactct
2011441 caccgcccag gtcatgatgg tcaccttgtt cgccgccggc ggcgagtcca cggcggcgct
2011501 gctgggcagc gcggtatgga tactggcgac acgtcccgat atccagcaac aggtgcgcgc
2011561 gaaccccgag ctgctgggag cgtttatcga agagacgctg cgttacgagc cgccatttcg
2011621 cggccactac cgccacgtgc gaaacgccac caccttggac ggcacggaac tgcccgcgga
2011681 ttcgcacctg ctgctgttgt ggggcgcggc caaccgcgat ccagcccagt tcgaggcacc
2011741 cggcgagttc cgtcttgacc gtgcaggagg caaaggccac atcagtttcg gaaaaggggc
2011801 ccacttctgt gtcggcgctg cactggcacg cttggaggct cgaatcgtct tgcgtctgct
2011861 gctcgatcgc acctcggtaa ttgaggcagc cgatgtcggc gggtggttgc ccagtatcct
2011921 ggtgcgccgc atcgagcggc tagagctagc tgtacaatag gcgctcgacg actcctattg
2011981 cagcacaacg gatatcagca acagcaggtg ccaaccgcgg cgatcggatg cgtgagaata
2012041 gtgaaagtgg ttgtcgcggt caggatttct gcgatcaacc ctacccgcat gacgccggcg
2012101 ggtggccccc gccggccacg ataaatgctt cgaccgccgt ggcccgctcg taaccttcga
2012161 cctccacgcg ccactcgtag attcctggtt ccaagggaat tcccgcagga atgttgaggg
2012221 tgagcggcat gcgaaccgag gtgccgtgga ttgcgccagg agcgcggccc gcctcggcgg
2012281 cggcttcaaa gaggatccgc tgcggcccgt gtggtcccgg cacgaccacc ggatcgccgt
2012341 cggcggtgag caactggcat ttcagctggt gctgcttatt ggtctcatcc cagtcgatgt
2012401 caaggaacag taccaaagcg aatggggggg tcggtgtttg gcattgccgc cagcccagcc
2012461 cgagcgcatg gaccttcccg gactgggcat cagcctgcgc cgcgtccgac aggaacagac
2012521 tgaccctcat gtcgccgccg ctgcgatcga actcccgggt tccgattcca cccctgtcct
2012581 tccccaatgt gcaactagcc gaaggtcggt caataccgca cccacttaga ctgactccat
2012641 cccgacggca ggataatacg tggcgaccgg tagatctatg ttgtgctatc tgggcggtgg
2012701 cagctggcgc ggaccgtcgg gggaacgcag ttcatgcgga ccctcccgtt gggtcagctc
2012761 cccggtcgac ccaactgata ggctcgccag gtctcgcgga ggcacctgcg ctaacggcgg
2012821 gtgatcatcg ttggtagcca gccggctacg gcgcgcagag tccgacgatg cgatcgggtt
2012881 gctttcggca ggggcagccg gggagtggga ttccagcggg ggctggtcgt tggggtcgga
2012941 accttcggca ttgaccgtca ccttgtgggt gcgcttgaac gaaaacgcga tctcctcgac
2013001 ctcttcgaac acctgacgcg cggtgcgcaa cggcgcagtg gtgttgtcga gcattcgtgc
2013061 gacaaacggc ggcaccagtg ggcgaatcca ccgagccgca gccttggtgg cgtctgggat
2013121 cgaccggatc actggggttg cacgcttctc gcgtggttca accgcaccct ccggttggac
2013181 ctgtgccggc aggtttttcg cgataccggg gcggtgatgg gctgccccag caggcaattg
2013241 ggcgaccgtc cggctggcag cttcggtttc ggcggcgatg ggcagataca cctcgtcctc
2013301 cactggctgc aaggttcgct ccgacgaagc gcgcactgga ccttcgagcg cttcgacgac
2013361 tcggcggcgt tgctgttcgc ggtcgatttc ggcctgggcc tcgatggcga ggcgggtctg
2013421 ggtgagttgg tgctcggccc acatgatttc ggcggcccgg cgaacctccg cccgcttgat
2013481 cgcgatcgcg gtgtccgcct ccaactcggc gcgctcccgt tccgctcgcg cggccgcgtg
2013541 gcgatcgtgc gttgtgtcac cgcgccatag ccggagaatc agcggcaaca ggtacagcag
2013601 cgcgaagaaa gcgatcgcca gcattcgcgc cgtcaaggcg ccggcgctgg ccaatgtcag
2013661 atcgttcatg gcgacccagc gcgagcccaa accacgaccc gcatccgcga ccacggcctg
2013721 gcgcacctcg gcaagagcct gctcgtcgtg tgccattttg gcgtccaagg caggtgcttg
2013781 gtgatcacga gccgccagcg cgttgtccag ctcacgctgc gcgtcggcga gaagctggtt
2013841 cgccgttcgt gtttcgggcc ctcggccggg aacgccggtg atccgggtct gcgggcaggc
2013901 cggagttggg tggtattcgc agcgtgcgac gaccagcgca tcgtccagtc gtccgcgcgc
2013961 ccgctcgacc gcgctgtcca gcgcagtgcg cgcattgcgg gcctgttgca gggaggccga
2014021 cgcttgcacg gccgccggcg tcgcgtcggc gctgtgcata gcttgttcat cgagacggcg
2014081 gtcgatggca ccggaaaaca tgaccagcgc agcgagttcg ccgacgacga aaccgacggc
2014141 gaccgcgacg gacgcgcgtc ccgtaacgcc ggcccgaccg cgagctgggc cactggccgt
2014201 accgcgggtc accgcgccga ccagcaggcc gagcaccagg gcgagcgagg cagccccgat
2014261 gggggacgag atcggcccct gggccgcctc gctcaccgcg aggctcgcga ggagtccggc
2014321 cagcgcggcg cccacggcca caatcacgcc ggccacggcg tgcgtggacc gctcgtgacg
2014381 ctcgccgagt tcgcgccagt gtccgccgcc gagccaggta agcagcccct cgattccgga
2014441 cacggccgag cgctgctcag catattcgtg ggcgcacatg agactgaaaa cacctcctgc
2014501 tggtcaagcc tggcaggccc ccgcccgaca caccgaatcg aagcggcccc ttgtggtgtt
2014561 gttcacaact gcgcgagaga tgacgcagat cacgtcgcgg ctgcccagcc gaatcctcag
2014621 cgagttcaat gtcaaaatta ccgcggcgcg agcggatcag cggccattat ggcaggtgac
2014681 gtgagacggt atacacctat gcaaaatcac gactacgtta cctacgaaga gttcggccgc
2014741 agattcttcg aggtagcagt taccccggac cgcgtcgccg ccgcgtttgc cgacatcgcg
2014801 ggcagcgagt tcgcaatgga accgatctcc cagggccccg gcgggatcgc caaggttagc
2014861 gcgaacgtca agatccgaga gccccgggtg acgcgaaagc tgggtgacct gatcacgttt
2014921 gtcatccata tcccgctgtc gatcgatctc cttcttgacc tgcgcctcga caagcagcgg
2014981 tttatggtcg ccggcgacat cgcgctgcgc gccaccgcac gcgccgccga gccgctgcta
2015041 ctgattgtcg acgtcgccaa accgcggccc tctgatatca cggtcaacgt gtcgtcgaag
2015101 tcgatccgcg gtgaggtgtt gcgcatcctc gcaggcgttg acggtgagat tcggcgattt
2015161 atcgcccagt acgtctctgc cgagatcgac tcgcccaaat cccaagccgc tcaagtcatc
2015221 aatgtggccg aacaattgga ctctacctgg agcggcccgt agccagctct ggatgcagtc
2015281 tggctgccgg ccaccgaaag ctcaccaaca gctcatcggt gaggtcgtcg cagcgcgcac
2015341 cgcctcggcc aaggtggctg ccctgcgatc ggtgaagatg tcctcgagca gcatcggctg
2015401 accgtcgggg ccggtgagcg gcacccgcca gttcgggtac tcgtcggtgg tgccaggctg
2015461 gttttgcgtc cggcggtcgc cgaccgcatc ggtcaacgcc actgccaaca gccgcgaggg
2015521 cgttcggccc aggtagcggt agagagccag gacggcctcc tccgagtcgg gctcggcacc
2015581 gtccgccagc agtccgaccc ggcgcagctc ggccatccag gctgcccggt cggcccgggc
2015641 ggattcgagt tccgcctcca cggggttggt taacaaccca agggactcgc gcagccgtac
2015701 ctggtcgccg gccaggtagc cggcggtcgg cggcagatca tgggtggtca ccgacgacaa
2015761 gcagtactcc cgccagcgtt cggccggcaa tggtgttcca gccggcccgc aatctcgatc
2015821 ctgctcaaac cagagaattg aggtgcccag caggccccgc aatagtagat agtcgcgtac
2015881 ccacggctcg acggtgccga gatcctcacc gacgacaacc gccccggccc ggtgggcttc
2015941 cagggcgacg atgccgatca tcgcgtcgtg gtcgtagcgc acataggtgc cttgggtggg
2016001 cggtgcgccg tcggggatcc accacaaccg gaacagcccg atgatgtggt cgatgcgtac
2016061 cgcaccggcg tgccgcaacg cggcctggat cagcgcgcga aacggtcggt actcctgctc
2016121 agcgagccgg tccggccgcc acggtggctg cgaccagtcc tggccgagtt ggttgaactc
2016181 atccggcggc gcacctgcgg tcacaccttg ggccagcacg tcctgcagag cccaggcgtc
2016241 ggccccgttg gggtgcacgc caacggcgag gtctgccatg atgcccagcg acatgccggc
2016301 ccggagcgcc tgcgactgcg cactggcgag ctgctcgtcc agctgccact gcagccagcg
2016361 gtggaaatcg acggcatcgg cgtgtttgtc gacgaaatcg gcgacacctg aggcatcggg
2016421 atgccgcagc gatttcggcc atcgatgcca atcatcgccg tacgtctcgg ccagcgcgca
2016481 ccaggtggcg aagtcgtcga gggcgcggcc ctcgcgggta cggaaggcgg cgtaggccag
2016541 ctcgcgaccc gccgaccgcg gcacccggtg cacgagcttg agtgctgcgc gtttggccgc
2016601 ccaggcgctg tcgcggtcaa tggtgtcgag ctggtcggcg tgctgttgca cgttggtgcg
2016661 caaccgttgc acccggccac gcttgggcag atcgacgagt tccggaatgg cctccacccg
2016721 aaggtagaga gggttgacga agcgtcgcga tgtcggcagg tagggcgatg gttcgattgg
2016781 cttcgagcgc ccagcgggcc cgggaagcgt agccgcatgc aggggattga ccagcacata
2016841 gccggcaccg tgcgcagacg ccgaccacag cgcgagattc gccaaatcgg tgagatcccc
2016901 gatgccccat gactgccggg accgcacgct gtagagctgg acggccaggc cccaggcacg
2016961 acggcctgcc agcttgtccg gcagccccaa ccaatccggc gtcacgacaa cagcggcgct
2017021 ggcctgcgag tcgcccgaac gcagattcac ccggtggtag ccgaggggca ggtcggcggg
2017081 caacacgaag ctggcctcgc cgatccagcg tccgtcaaga tcgaatggcg gggtgaaatt
2017141 gtcgacctgc accacctcgg cacgtgtcgt gccgtcctcg agctgcaacc acacgtcggc
2017201 cggagcgcca tcggtcacat gcaccctgaa ctgcgtctgc tctccggcgc gcatgacgat
2017261 ggtcgccggc aatggacgcg cccagtagga tcgcagctgc gcggccaggg cgtcattgcg
2017321 ttgctgttcg gtctgggcgg gaacgccgag ggcggcaaga gcagccacca atgtagcctc
2017381 ggagaccagc acctgccggc cagtccagtc cgtgtactcg gtggcaatgc cgaatcgtcg
2017441 ggcaagttcg accagcgaag gcgcgagctc ggtcatgtcg cccatcttgc gtccggcacc
2017501 cgtgtgcggg cgagcgcagg aatctgagcc ttccgtcagc acagcacggt tggctaccga
2017561 acaccactac gttgcaggtc aacgaggtag actgcggagc ggacagttcc acaggcggac
2017621 tcggtcattc gccgctacca tgcccagtga agacacgacg aatccttggg ggatccgcgc
2017681 agtggcaaat acccaggtca atgtccaggt gttctgagca gaccggaagg tgatctagcg
2017741 tggctgaaga gagccgcggg cagcgggggt cggggtatgg ccttgggttg tccacgcgga
2017801 cccaggtaac cggttatcag ttcctggcgc gtcgaaccgc aatggcgttg acacgctggc
2017861 gtgtgcgtat ggagattgag ccgggtcggc ggcagacgtt ggcggtggtg gcgtcggtgt
2017921 cggcggcgtt ggtgatctgt ctgggggcgc tgttgtggtc gttcatcagc ccgtccggcc
2017981 agttgaatga gtcgccgatc atcgcagacc gcgattccgg tgcgctctat gtccgtgtcg
2018041 gtgacaggtt gtacccggcg ctgaatttgg catcggcacg gctgatcacc gggcggccgg
2018101 acaacccgca cctggttcgg tcaagccaga ttgccaccat gccgcgcggt ccgctggtgg
2018161 gtatcccggg tgcgccgtca tcgttctcgc caaagagtcc acccgcgtcg tcttggctgg
2018221 tctgcgacac ggtagcgacc tcgtcaagca tcgggtcgct gcaaggcgtg acggtgacgg
2018281 tcatcgacgg gaccccggac cttaccggtc accggcagat tttgagtgga tcggacgcgg
2018341 tagtgctgcg ctacggcgga gatgcgtggg tcatccggga ggggcgccgg tcacgaatcg
2018401 agccgacgaa tcgagcggtg ttgttgccgc tggggttgac gccggagcag gttagccagg
2018461 cgcgtccgat gagccgggca ttgttcgacg ctttgccggt cgggcccgaa ctgttggtgc
2018521 cggaagtgcc gaatgcgggt ggtcctgcga cgttcccggg cgctcccgga ccgatcggga
2018581 cggtaatcgt cacaccgcaa atcagtggac cacaacagta ttcgttggtc ctgggcgatg
2018641 gagtgcaaac gctcccgccg ttggtggccc agatcctgca gaacgctggt agtgcgggca
2018701 acaccaagcc gttgaccgtg gaaccctcaa cgctggccaa gatgccggtg gtgaatcggt
2018761 tggatctctc tgcgtatccg gacaatcccc tggaagtggt ggacattcgc gagcatccgt
2018821 cgacctgttg gtggtgggag cggacggccg gtgaaaaccg ggcccgtgtg cgggtcgtgt
2018881 ccgggcctac cattccggtc gcggcgaccg agatgaacaa ggtggtgtcg ttggtgaagg
2018941 ccgacacgag tggccgccaa gccgatcagg tctacttcgg ccccgaccat gcgaacttcg
2019001 tggccgtcac cggcaacaac ccgggggccc aaacgtccga atcgctatgg tgggtgaccg
2019061 atgcgggcgc gcggttcggg gtggaggaca gcaaagaagc gcgtgacgcg ttggggttga
2019121 ccctgacgcc gagcctggcg ccgtgggtgg cgctgcggct gctgccacag ggccccacgc
2019181 tgtcacgagc ggacgcgttg gtggagcacg acacgctccc aatggacatg acccctgcag
2019241 agttggtggt accgaaatga agcgtggttt tgcccgcccg acaccggaaa agcctccggt
2019301 catcaagccc gagaatattg tcctatcgac accgctgagc attccgccgc cggagggcaa
2019361 gccctggtgg ctgattgtgg ttggcgtcgt ggtggtgggc ctgctgggcg gcatggtcgc
2019421 catggttttc gccagcggat cacacgtgtt cggcggcatc ggctcgatct tcccgctctt
2019481 catgatggtc gggatcatga tgatgatgtt ccgcggcatg ggcggcggcc aacagcaaat
2019541 gagccggccg aaattggacg cgatgcgcgc tcagttcatg ttgatgctgg acatgctgcg
2019601 cgagacggcc caagagtcgg ccgacagcat ggacgccaac tatcggtggt tccacccggc
2019661 gcccaatacg ttggcggccg ccgtggggtc accccggatg tgggagcgca agcccgacgg
2019721 taaggacctg aacttcgggg ttgtccgcgt cggcgtggga atgacgcgtc ccgaagtgac
2019781 ctggggtgag ccgcagaata tgccgaccga catcgagctg gagccggtga caggtaaggc
2019841 gctgcaggaa ttcgggcgct accaaagcgt cgtgtacaac ctgccgaaaa tggtttcgct
2019901 gctggtcgaa ccctggtatg cgctggtcgg ggaacgcgag caggttctgg gtttgatgcg
2019961 ggcgatcatc tgccagctgg cgttctccca cgggcctgac catgtccaga tgatcgttgt
2020021 cagttccgat ctagaccaat gggactgggt gaagtggcta ccgcatttcg gtgactcgcg
2020081 gcggcacgac gcggcgggta acgcgcggat ggtctacacc tcggttcgtg agtttgccgc
2020141 agagcaagcc gaattattcg cgggccgtgg ttctttcacg cctcgacacg cgagttcgtc
2020201 ggcgcagacc ccgaccccgc acaccgtgat catcgccgac gtcgacgatc cgcaatggga
2020261 gtacgtgatc agcgccgagg gtgtcgacgg ggtgacgttc ttcgacctga ccggctcttc
2020321 gatgtggact gacatcccgg agcggaagct gcagttcgac aagaccggcg tgatcgaggc
2020381 gctgccccgc gaccgcgaca cctggatggt gatcgacgac aaggcttggt tcttcgctct
2020441 caccgaccaa gtcagcatcg ccgaggcaga agagttcgcg cagaagctgg cgcagtggcg
2020501 gctggctgag gcctatgaag agatcggcca gcgggttgcc cacattggtg cccgagacat
2020561 cttgtcctac tacgggattg acgatcctgg caacatcgac ttcgactcgc tgtgggctag
2020621 ccggaccgac accatgggac ggtcgcgatt gcgggcgccg ttcggtaatc gctccgacaa
2020681 cggcgagctg ctgttcttgg atatgaaatc gctcgacgaa ggcggcgacg gcccgcacgg
2020741 ggtcatgtcc gggacgaccg gttccggtaa gtcgacgttg gtgcgaaccg tgatcgaatc
2020801 gctgatgctc agccatccgc cggaggagtt gcagttcgtt ttggcagacc tcaaaggtgg
2020861 ctcggcggtc aagccgttcg cgggagtgcc acacgtgtcg cggatcatca ccgacctcga
2020921 agaagaccag gcgctcatgg agcgctttct ggatgcgctg tggggcgaga tcgcccgccg
2020981 caaagcaata tgcgacagcg ccggtgtcga cgacgccaaa gagtacaact cggtgcgagc
2021041 caggatgcgt gcgcgcggtc aggacatggc gccgctgccg atgctcgtgg tggtcatcga
2021101 cgagttctac gaatggttcc gcatcatgcc gacggcggtc gacgtcctcg actcgatcgg
2021161 ccggcagggc cgcgcctact ggattcacct gatgatggcg tctcagacca tcgagagccg
2021221 agccgaaaag ctcatggaga acatgggtta ccgcttggtg ctgaaagcgc gtaccgcggg
2021281 agcggcgcag gcggccgggg tgcccaacgc ggtgaatctg cccgcacagg ccggtctggg
2021341 ctacttccgc aagagcctcg aggacatcat ccgattccag gcggaattcc tgtggcggga
2021401 ctacttccaa cccggcgtca gcatcgacgg cgaggaagcg cctgccttag tacacagcat
2021461 cgactacatt cgcccgcaat tgtttaccaa ctcgttcaca ccgctggaag ttagcgtggg
2021521 gggtcccgat atcgagccgg tagttgccca gcccaacggt gaggtgctcg agtcggacga
2021581 cattgaaggc ggcgaggacg aggacgaaga gggggtgcgc accccgaagg ttgggacggt
2021641 gatcattgat cagctgcgca agatcaagtt cgagccgtac cggctctggc aaccgccact
2021701 aacccaaccc gtcgccatcg acgacttggt caaccggttc ctcggccgcc cgtggcacaa
2021761 ggagtacggt tcggcgtgca atctcgtgtt cccgatcggg ataatcgatc gcccctataa
2021821 gcatgaccag ccaccgtgga cggttgacac ctccgggccc ggtgccaacg tgctaatcct
2021881 gggcgccggc ggttcgggca agaccactgc gctgcagaca ctcatctgct cagcggcact
2021941 gactcacacc ccgcagcagg ttcagttcta ctgcctggcc tacagcagca ccgcgttgac
2022001 cacggtctcc cgcatccccc acgtgggcga ggttgccggt cccaccgatc cctacggtgt
2022061 gcgccggacg gtggccgagt tgctggcgct ggtgcgcgag cgcaaacgca gcttcctgga
2022121 atgcggaatc gcgtcgatgg agatgttccg gcgccgcaag ttcggcggag aggccgggcc
2022181 ggtacccgac gacggcttcg gtgacgtcta cctggtgatc gataactacc gggccctggc
2022241 cgaagaaaac gaggtgctga tcgagcaggt gaacgtgatc atcaaccagg gcccctcgtt
2022301 cggggtgcac gtggtggtca ctgccgaccg cgaatcggag ctgcggccgc cggtgcgcag
2022361 cggcttcgga tcccgtatcg agctgcgctt ggcggcggtt gaggacgcca agctggtgcg
2022421 ttctcgattc gccaaggacg ttccggtcaa gccggggcgc ggcatggttg cggtcaacta
2022481 cgtccgcctg gacagcgacc cgcaggccgg cctgcacacc ctggtggctc gaccggcgtt
2022541 gggcagcaca cccgacaatg tcttcgagtg cgacagcgtg gtcgcggcgg tgagccggct
2022601 caccagcgcc caggctccac cggtgcgccg gttgccggcg cggttcggcg tggaacaggt
2022661 gcgggagctg gcctcgcggg acacccgcca aggcgttggc gctggcggaa tcgcctgggc
2022721 gatatcggaa ttggatctgg cgccggttta tctgaatttc gccgagaatt cgcacctgat
2022781 ggtgactggt cgacgcgaat gtggccgcac caccacgctg gccaccatca tgtccgaaat
2022841 cgggcggctc tacgcgccgg gcgccagtag cgcaccgcct cccgcccccg ggcggccctc
2022901 tgcgcaggta tggctggtcg acccgcgccg tcagctgctg accgcgctcg gttcggacta
2022961 tgtggagcgg ttcgcctaca acctcgacgg ggtggtggcg atgatgggtg aacttgcggc
2023021 ggcgttggcc ggtcgtgagc cgccaccggg cctgtccgcc gaagagttgt tgtcgcggtc
2023081 gtggtggagc ggcccagaaa tcttcctgat cgtcgacgac atccagcagc tgccgccggg
2023141 cttcgattca ccgttgcaca aggctgttcc gtttgtgaac agggccgccg atgtcggctt
2023201 gcatgtgatc gtcacgcgca ccttcggtgg ttggtcgtca gccggcagcg acccgatgtt
2023261 gcgggccctg catcaggcca atgcgccact gctggtgatg gacgccgatc ccgacgaggg
2023321 cttcattcgc ggcaagatga agggcggccc gctgccccgc ggtcgaggcc tgttgatggc
2023381 agaagacacc ggtgtgttcg tccaagtggc agccaccgag gtgcgtcggt agttcggcca
2023441 aaccgatcag ctccagcgta gcggcaagtt cttaagcgcg aaggacttgg acgggaaccg
2023501 tatttcgggc gcgtagtccg gcgcgagctc gaagtcggga atttgattca gccactcgcc
2023561 caccagcagg gtgagctcta aacgggctag atgcgaaccc aggcaacggt gtggaccgcc
2023621 gccaaatccc cagtgccggt gcacctttcc atccatcacc aactcgtcgg tggacatcgc
2023681 gtcgctgccg tcgcggttga ctgcggccat gcataaccgc actggtgacc ccgcaggcag
2023741 tgtcatgccg ccgacggtga cgggctcggt ggtaactcgc ggcgccaccg gcgccgatgg
2023801 ctccagccgg acgatctctt cgatgaaaac cctgatctgc ttgggattgt cgcgcagcat
2023861 ggcgcgcagc tgtggtctgc gggcgagctc gagcagcgaa aagcctaccg ctgccgtcac
2023921 ggtgtccagt cccgccagta tcaggaggtg gctcaaaccc aaaacctcga tctcgctcaa
2023981 cgggtcctcg ccgatctgca cttgcgacaa gacgtccggc cctgggtttc gccggcgttc
2024041 ggcgaccatg gccgtgagat actcgagcag ctcgcgcgcc gcagcgacat cggcttcggt
2024101 cgggtgaggt cgatccgaca tggcgatgac ggcgtctttc cagccgatca gacggtcacg
2024161 gtcttcgagc ggcaggccgt acaggacgag aaacaactga aacggaaaca gattcgcgag
2024221 atcggccatc gcctcgcact cgccccggcc tgcgatggcg tcgatcatag cgacagtgtg
2024281 acggcgcagc gacggtagcg ccttgctcaa agcggccggg ctgaagtatg gctgcaggat
2024341 cctgcggtat cgggtgtgct cgggcgggtc gaacgcgagc ggaaccaccg gcagcggatt
2024401 tcccggaggt tgcagcgctt tccgcgacga gaaaaccttc ggattccgca gcgccgcgag
2024461 cacatcttcg cggcgcgtca ggtagtacca gccgttcatg aacaccacgg gccccgcgtc
2024521 gcggagggtc ttccagccga caccccggtc aacggccatc ggtaacgtcg aatattcgag
2024581 ccgcggtaga taaaacgagc cggcgtggtc ctcgccgggg gtggtcatgc gctcaagtct
2024641 ttcgtgtctc cgttcttgtc gcaggtcgca gacgtagcca agcggtgccg acctagccaa
2024701 tatcgcacgt gggcgtgcac ccaccattgt ggtgtcgagc gcatctgggg gctcagcggc
2024761 taatcttcga agcgaactgt ccggtccaag ctggcgtgtg ctttgggcgg taaagggagg
2024821 aaatcccgtg aaagtccgtc tcgatccatc gagatgcgtg ggtcatgcgc agtgctatgc
2024881 cgtcgatccg gacctgttcc cgatcgacga ctcgggcaac tcgatcctgg cagagcacga
2024941 ggtgcggccc gaggacatgc agctgaccag agacggtgtg gccgcttgcc ccgaaatggc
2025001 gctcatcctc gaggaggacg acgcggactg acgattccgg gtcataccac aaaattaacg
2025061 ctggccaaac gatcgtttac gaggaatgaa tatttggcgt catcggcgct ggaggccggt
2025121 attgcaatct aatgtgtttt ctatgcaaca gttgcgcagc gacgccgtta tcgactagcg
2025181 gtgctatatt cggcgccttt tcgatgccga gcgcgcgtct cgttggccac gtttggtggc
2025241 aatgctcatc agggctcatc cggatcgcca acgcgatcgt gtgtggagag ggaggactgg
2025301 ttggacttcg gggcgttacc gccggagatc aattcgggcc gtatgtattg cggtccgggg
2025361 tcggggccga tgctggctgc ggccgcggcc tgggacgggg tggccgtgga gttggggttg
2025421 gctgcgaccg gttatgcgtc ggtgatagcc gagctgaccg gtgcgccgtg ggtgggtgcg
2025481 gcgtcgttgt cgatggtggc ggcggccacg ccgtatgtgg cctggctgag ccaagccgcg
2025541 gcgcgggccg agcaggcggg gatgcaggcc gcggcggccg cggcggctta tgaggccgct
2025601 tttgtgatga cggtgccgcc gccggtgatt acggcgaatc gggttttggt gatgacgctg
2025661 attgcgacca attttttcgg tcagaactcg gcggcgatcg cggtcgctga ggcgcagtac
2025721 gccgaaatgt gggcgcaaga cgccgttgct atgtatggct atgcggctgc gtcggcgagc
2025781 gcgtcgcggt tgattccgtt cgcggcgccg ccgaagacca ccaactccgc tggggtggtc
2025841 gcacaggtgg ctgcggtcgc ggcgatgcct ggactgctgc aacgactttc gtcggctgca
2025901 tcggtcagct ggtcgaatcc caatgattgg tggctcgtgc ggttgctggg ctcgattacc
2025961 cccacggaaa ggacgacgat cgttcgtttg ctcggtcagt cgtacttcgc gacgggcatg
2026021 gcgcagttct tcgcctcgat cgcacagcag ctgaccttcg gcccaggggg cacaacggct
2026081 ggctccggcg gagcctggta cccaacgccg caattcgccg gcctgggtgc aagccgggcg
2026141 gtgtcggcga gtttggcgcg ggccaacaag attggggctc tgtcggttcc gccgagctgg
2026201 gtcaaaacga ctgcactgac cgaaagcccg gtcgcccacg cggtgagcgc caaccctacc
2026261 gtcggttcgt cacacggacc gcatggcctg ctccgcggac tgccgctagg gtcgcggatc
2026321 actcggcgta gcggcgcctt tgcccaccga tatgggttcc gtcacagtgt ggttgcccgc
2026381 ccgccatcgg ccggataacg ccatgacctc agctcggcag aaatgacaat gctcccaaag
2026441 gcgtgagcac ccgaagacaa ctaagcagga gatcgcatgt cgtttgtgac tacccaacca
2026501 gaagcactgg cggcggcggc cggcagtctg cagggaatcg gctccgcatt gaacgcccag
2026561 aatgcggctg cggcgactcc cacgacgggg gtggtcccgg cggccgccga tgaagtgtcg
2026621 gcgctgacgg cggctcagtt cgcggcacac gcccagatct atcaggccgt cagcgcccag
2026681 gccgcggcga ttcacgagat gttcgtcaac actctacaga tgagctcagg gtcgtatgct
2026741 gctaccgagg ccgccaacgc ggccgcggcc ggctagagga gtcactgcga tggattttgg
2026801 ggcgttgccg ccggaggtca attcggtgcg gatgtatgcc ggtcctggct cggcaccaat
2026861 ggtcgctgcg gcgtcggcct ggaacgggtt ggccgcggag ctgagttcgg cggccaccgg
2026921 ttatgagacg gtgatcactc agctcagcag tgaggggtgg ctaggtccgg cgtcagcggc
2026981 gatggccgag gcagttgcgc cgtatgtggc gtggatgagt gccgctgcgg cgcaagccga
2027041 gcaggcggcc acacaggcca gggccgccgc ggccgctttt gaggcggcgt ttgccgcgac
2027101 ggtgcctccg ccgttgatcg cggccaaccg ggcttcgttg atgcagctga tctcgacgaa
2027161 tgtctttggt cagaacacct cggcgatcgc ggccgccgaa gctcagtacg gcgagatgtg
2027221 ggcccaagac tccgcggcga tgtatgccta cgcgggcagt tcggcgagcg cctcggcggt
2027281 cacgccgttt agcacgccgc cgcagattgc caacccgacc gctcagggta cgcaggccgc
2027341 ggccgtggcc accgccgccg gtaccgccca gtcgacgctg acggagatga tcaccgggct
2027401 acccaacgcg ctgcaaagcc tcacctcacc tctgttgcag tcgtctaacg gtccgctgtc
2027461 gtggctgtgg cagatcttgt tcggcacgcc caatttcccc acctcaattt cggcactgct
2027521 gaccgacctg cagccctacg cgagcttctt ctataacacc gagggcctgc cgtacttcag
2027581 catcggcatg ggcaacaact tcattcagtc ggccaagacc ctgggattga tcggctcggc
2027641 ggcaccggct gcggtcgcgg ctgctgggga tgccgccaag ggcttgcctg gactgggcgg
2027701 gatgctcggt ggcgggccgg tggcggcggg tctgggcaat gcggcttcgg ttggcaagct
2027761 gtcggtgccg ccggtgtgga gtggaccgtt gcccgggtcg gtgactccgg gggctgctcc
2027821 gctaccggtg agtacggtca gtgccgcccc ggaggcggcg cccggaagcc tgttgggcgg
2027881 cctgccgcta gctggtgcgg gcggggccgg cgcgggtcca cgctacggat tccgtcccac
2027941 cgtcatggct cgcccaccct tcgccggata gtcgctgccg caacgtatta acgcgccggc
2028001 ctcggctggt gtggtccgct gcgggtggca attggtcggc gccgagatct cggtgggtta
2028061 tttgcggtgg gattttttcc cgaagccggg ttcagcaccg gatttcctaa cggtcccgcg
2028121 actcaacggc accgcgccgt cagcaagttc cggtggtgtt gatcgcggta tccatgcagg
2028181 tggtgatggc gcggcgagac tggtcgtgtg cgctgaagca cagggtactt ggcggttgtg
2028241 gctcccggga tgtagctggc cgcccaacgt cccgcagcgt cggggtcagc ggcggagcag
2028301 cacggcgatt tagcctcaca accgagcagc tagctcgcgt ttcccagcgg ctcaatcccc
2028361 gtcgagccat tgaaaggcac ctcagatgtc gtttgcgact ccgcaaccgg agaaagggtt
2028421 cggaatggac ttcggggcgt taccgccgga gatcaattcg ggccgtatgt attgcggtcc
2028481 ggggtcgggg ccgatgctgg ctgcggccgc ggcctgggac ggggtggccg tggagttggg
2028541 gttggctgcg accggttatg cgtcggtgat agccgagctg accggtgcgc cgtgggtggg
2028601 tgcggcgtcg ttgtcgatgg tggcggcggc cacgccgtat gtggcctggc tgagccaagc
2028661 cgcggcgcgg gccgagcagg cggggatgca ggccgcggcg gccgcggcgg cttatgaggc
2028721 cgcttttgtg atgacggtgc cgccgccggt gattacggcg aatcgggttt tggtgatgac
2028781 gctgattgcg accaattttt tcggtcagaa ctcggcggcg atcgcggtcg ctgaggcgca
2028841 gtacgccgaa atgtgggcgc aagacgccgt tgctatgtat ggctatgcgg ctgcgtcggc
2028901 gagcgcgtcg cggttgattc cgttcgcggc gccgccgaag accaccaact ccgctggggt
2028961 ggtcgcacag gcggttgcgt cggtcagctg gccgaatccc aatgattggt ggctcgtgcg
2029021 gttgctgggc tcgattaccc ccacggaaag gacgacgatc gttcgtttgc tcggtcagtc
2029081 gtacttggcg acgggcatgg cgcggtttct tacctcgatc gcacagcagc tgaccttcgg
2029141 cccagggggc acaacggctg gctccggcgg agcctggtac ccaacgccac aattcgccgg
2029201 cctgggtgca ggcccggcgg tgtcggcgag tttggcgcgg gcggagccgg tcgggaggtt
2029261 gtcggtgccg ccaagttggg ccgtcgcggc tccggccttc gcggagaagc ctgaggcggg
2029321 cacgccgatg tccgtcatcg gcgaagcgtc cagctgcggt cagggaggcc tgcttcgagg
2029381 cataccgctg gcgagagcgg ggcggcgtac gggcgccttc gctcaccgat acgggttccg
2029441 ccacagcgtg attacccggt ctccgtcggc gggatagctt tcgatccggt ctgcgcggcc
2029501 gccggaaatg ctgcagatag cgatcgaccg cgccggtcgg taaacgccgc acacggcact
2029561 atcaatgcgc acggcgggcg ttgatgccaa attgaccgtc ccgacggggc tttatctgcg
2029621 gcaagatttc atccccagcc cggtcggtgg gccgataaat acgctggtca gcgcgactct
2029681 tccggctgaa ttcgatgctc tgggcgcccg ctcgacgccg agtatctcga gtgggccgca
2029741 aacccggtca aacgctgtta ctgtggcgtt accacaggtg aatttgcggt gccaactggt
2029801 gaacacttgc gaacgggtgg catcgaaatc aacttgttgc gttgcagtga tctactctct
2029861 tgcagagagc cgttgctggg attaattggg agaggaagac agcatgtcgt tcgtgaccac
2029921 acagccggaa gccctggcag ctgcggcggc gaacctacag ggtattggca cgacaatgaa
2029981 cgcccagaac gcggccgcgg ctgctccaac caccggagta gtgcccgcag ccgccgatga
2030041 agtatcagcg ctgaccgcgg ctcagtttgc tgcgcacgcg cagatgtacc aaacggtcag
2030101 cgcccaggcc gcggccattc acgaaatgtt cgtgaacacg ctggtggcca gttctggctc
2030161 atacgcggcc accgaggcgg ccaacgcagc cgctgccggc tgaacgggct cgcacgaacc
2030221 tgctgaagga gagggggaac atccggagtt ctcgggtcag gggttgcgcc agcgcccagc
2030281 cgattcagct atcggcgtcc ataacagcag acgatctagg cattcagtac taaggagaca
2030341 ggcaacatgg cctcacgttt tatgacggat ccgcatgcga tgcgggacat ggcgggccgt
2030401 tttgaggtgc acgcccagac ggtggaggac gaggctcgcc ggatgtgggc gtccgcgcaa
2030461 aacatttccg gtgcgggctg gagtggcatg gccgaggcga cctcgctaga caccatgacc
2030521 tagatgaatc aggcgtttcg caacatcgtg aacatgctgc acggggtgcg tgacgggctg
2030581 gttcgcgacg ccaacaacta cgaacagcaa gagcaggcct cccagcagat cctgagcagc
2030641 tagcgccgaa agccacagct gcgtacgctt tctcacatta ggagaacacc aatatgacga
2030701 ttaattacca gttcggggac gtcgacgctc atggcgccat gatccgcgct caggcggcgt
2030761 cgcttgaggc ggagcatcag gccatcgttc gtgatgtgtt ggccgcgggt gacttttggg
2030821 gcggcgccgg ttcggtggct tgccaggagt tcattaccca gttgggccgt aacttccagg
2030881 tgatctacga gcaggccaac gcccacgggc agaaggtgca ggctgccggc aacaacatgg
2030941 cgcaaaccga cagcgccgtc ggctccagct gggcctaaaa ctgaacttca gtcgcggcag
2031001 cacaccaacc agccggtgtg ctgctgtgtc ctgcagttaa ctagcactcg accgctgagg
2031061 tagcgatgga tcaacagagt acccgcaccg acatcaccgt caacgtcgac ggcttctgga
2031121 tgcttcaggc gctactggat atccgccacg ttgcgcctga gttacgttgc cggccgtacg
2031181 tctccaccga ttccaatgac tggctaaacg agcacccggg gatggcggtc atgcgcgagc
2031241 agggcattgt cgtcaacgac gcggtcaacg aacaggtcgc tgcccggatg aaggtgcttg
2031301 ccgcacctga tcttgaagtc gtcgccctgc tgtcacgcgg caagttgctg tacggggtca
2031361 tagacgacga gaaccagccg ccgggttcgc gtgacatccc tgacaatgag ttccgggtgg
2031421 tgttggcccg gcgaggccag cactgggtgt cggcggtacg ggttggcaat gacatcaccg
2031481 tcgatgacgt gacggtctcg gatagcgcct cgatcgccgc actggtaatg gacggtctgg
2031541 agtcgattca ccacgccgac ccagccgcga tcaacgcggt caacgtgcca atggaggaga
2031601 tgctagaggc aacgaagtcg tggcaggaat cggggtttaa cgtcttctcc ggcggagatc
2031661 tgcgccgaat gggcatcagt gccgcgacgg tggccgcgct ggggcaggcg ttgtcggatc
2031721 ccgcggccga ggtcgcagtg tatgcgcgac agtaccgaga cgacgccaag ggccccagcg
2031781 cctcggtgtt gtcgctgaaa gacggctccg gtggacgcat cgcgctgtat cagcaggcgc
2031841 gaacggcagg ttccggcgag gcgtggctgg ctatctgccc ggctaccccg cagttggtgc
2031901 aagtaggagt gaagaccgtt ttggatacac tgccctacgg cgagtggaaa acacacagca
2031961 gagtatgacg ccagggcgtg aaacccgaag tacaacaaca aatttgagca tcagatacaa
2032021 cccagatacg tacagggcaa attgctctag aatcgactgc aatactgcaa ggcaaggtca
2032081 accacaacga tttggtcgcg aggcaaggca aatgaaatcg gagttagtcg agccgcagct
2032141 cccggtgggc taccgcgcct cggtgcctac accgacggag ctccccgcgc cactgaagcc
2032201 acggtgtaac acgtttgcca tggcaggggg tacaggacga tgaccgcagt agctgacgca
2032261 cctcaggctg acattgaggg tgtggcatcg ccccaggctg tcgtcgtggg cgtcatggcc
2032321 ggcgaaggcg tccagatcgg cgtcctgctg gatgccaacg ccccagtttc ggtgatgacc
2032381 gacccgctgc tgaaagtggt taatagtcgg ctcagagagc tcggtgaggc tccactggaa
2032441 gccactggac gcggccgatg ggcgctgtgt ctggtggacg gcgcgccgtt gcgtgctacc
2032501 cagtcgctga ccgaacaaga cgtctatgac ggcgaccggc tgtggattcg gttcatcgca
2032561 gacaccgaac gtcgctccca agtcatcgaa catatctcca ccgcagtcgc ctcggatctc
2032621 agcaagcggt tcgccaggat cgacccgatc gttgctgtgc aggtcggggc gtcgatggtg
2032681 gcgaccgggg ttgttcttgc caccggggtg ctcggctggt ggcgctggca tcacaacacc
2032741 tggttgacca ccatctacac cgcggtgatt ggtgtgctgg tgctggcggt cgccatgttg
2032801 ctgttgatgc gtgccaagac ggacgcggat cgacgcgtcg ccgacatcat gctgatgagc
2032861 gcgatcatgc ccgtgacggt ggcggcggca gcggccccgc ccggcccggt gggctccccg
2032921 caggccgtgt tgggcttcgg agtgctgacc gtcgctgcgg ccctggccct gcggttcacc
2032981 ggtcgccgcc tggggattta caccacaatc gtcatcatcg gtgcgctgac aatgcttgca
2033041 gccttggcgc ggatggtcgc ggccacaagc gcggtgacgc tgttgtcgtc cttgttgttg
2033101 atttgcgtag tggcctacca cgcggcgccg gcactgtctc ggcggctggc cggcatccga
2033161 ctgccggtgt tcccgtccgc caccagccgg tgggtcttcg aggctcggcc cgacctaccg
2033221 accaccgtgg tggtgtccgg tggcagcgca ccggtcttgg aagggccgtc atcggtgcgt
2033281 gatgtgctgc tgcaagctga gcgcgctcgg tcgttcttga gcggcctgct aacgggactt
2033341 ggcgtgatgg tggtggtgtg catgacatcg ttgtgcgacc cgcacaccgg gcaacgttgg
2033401 ctgccgctga tactggccgg atttacctcg ggcttcctgc tgttgcgggg ccgctcctac
2033461 gtcgaccgtt ggcagtcgat taccctggcc ggaactgcgg tgatcatcgc tgctgcggtg
2033521 tgtgtgcggt acgcgctgga attgtcctcg ccgttggctg tgtccattgt cgccgcgatc
2033581 ctggtgctgc tgccggcggc gggcatggca gctgctgcac atgtgcccca caccatctac
2033641 agtccgctat tccgcaagtt tgtggaatgg attgaatacc tctgcctgat gccgatcttc
2033701 ccgctggcgt tgtggttgat gaacgtctat gcagcgattc ggtaccggta gcagcaggtc
2033761 gtggtgtggt cgcgcgggta ccgcgaccat tgccgcagtc ttgctagctt cgggcgcgct
2033821 gaccggcctt ccgccagcgt atgcaatttc gcctccgacg atcgatccgg gcgcgctgcc
2033881 acccgacggg ccgcccggac cgctggcgcc catgaagcag aacgcctact gcaccgaggt
2033941 cggggtcttg cccggcaccg actttcagct gcagccaaaa tatatggaga tgctgaacct
2034001 gaacgaggct tggcagttcg gccgcggcga cggtgtgaag gtcgctgtca tcgacacggg
2034061 tgtgactcca catccccggt tgccgcgtct gatccctggc ggcgactacg tgatggccgg
2034121 tggcgacggt ctgtcggact gcgacgccca cggcaccctg gtggcgtcga tgatcgcggc
2034181 ggttccggcg aacggggcgg taccgctgcc gtcggtaccg cgcaggccgg tcaccattcc
2034241 cacgaccgaa acgccgccgc cgccacagac ggtgaccctt tcaccggtac cgccgcagac
2034301 cgtgaccgtg attccggctc cacctcccga ggaaggagtt ccgccgggcg caccggtgcc
2034361 aggaccggag ccgccgccgg ctcctggtcc acagccgccg gccgtggacc gcggtggcgg
2034421 cacggtgaca gtacccagct actccggggg ccgcaagata gccccgatcg acaacccgcg
2034481 taatccgcac ccgagtgcgc catcgccagc gctgggacca ccgccggacg cgttcagtgg
2034541 gatcgccccc ggtgtcgaga taatctccat ccgccagtca agccaggcct tcggccttaa
2034601 ggacccttac actggggacg aagacccgca gacggcgcaa aagatcgaca acgtcgagac
2034661 aatggcgcgc gcgatcgtgc atgctgccaa catgggtgct tcggtgatca atatctccga
2034721 tgtgatgtgc atgagtgctc gtaatgtcat cgaccagcgt gcactgggtg ccgcggtgca
2034781 ctacgccgcg gtcgacaagg acgcggtcat cgtggctgca gcgggcgacg gcagcaagaa
2034841 ggactgtaag cagaacccga tttttgatcc cttgcagccc gacgatccac gcgcttggaa
2034901 cgcggtcacc acggtggtga caccctcgtg gttccacgac tacgtcctga cggtcggagc
2034961 ggttgacgcc aacggtcaac cgctcagcaa aatgagtatc gcgggaccct gggtctccat
2035021 ttcggcgccg ggaaccgacg tcgtcggact ctcgccccgt gacgacggcc tgatcaatgc
2035081 gattgacggc ccggataatt cgttgctggt tccggctggc accagttttt ccgccgcgat
2035141 cgtgtccggg gtggctgcgc tggtacgtgc taagttcccc gaattgtcgg cgtaccaaat
2035201 catcaatcgg ctgattcata ccgcccggcc acccgctcgc ggcgtcgaca accaggtcgg
2035261 ctacggtgtg gtcgacccag tggcagcact gacttgggat gtgcccaaag gcccggccga
2035321 gccgcccaag cagctgtcag cgccgttggt ggtgccgcag ccgcccgccc cccgcgatat
2035381 ggtgccgata tgggtggccg ccgggggatt ggccggggca ctattgatag gcggtgcggt
2035441 gttcggtacc gcgaccttga tgcggcgatc acggaagcag caatgaaggc tcagcgcagc
2035501 ttcgggttgg cgttgtcgtg gccgcgggtg accgcggtgt ttctggtgga tgtcctgatc
2035561 ttggcggtgg ccagtcattg cccggattcc tggcaggccg atcatcatgt ggcgtggtgg
2035621 gtcggcgtcg gcgtggcggc cgtagtgacg ttactgtcgg tggtcagtta ccacggcatc
2035681 acggtgattt cgggtttggc gacgtgggtg cgggattggt cggcggatcc gggcacgaca
2035741 ctgggtgcgg ggtgcactcc ggcaatcgac caccagcgcc gttttgggcg tgacacggta
2035801 ggggtgcgtg agtataacgg ccggctggtc tcggtgatcg aggtcacctg cggtgagagc
2035861 ggcccgtcgg gtcggcattg gcaccggaaa tcgccggtac ccatgttgcc ggtggtcgcg
2035921 gtcgccgatg gtttgcgcca gttcgacatt cacctcgatg gcatcgacat cgtgtcggtg
2035981 ctggtgcggg gcggggttga tgctgctaaa gcttcggcct cgctgcagga gtgggagccg
2036041 cagggctgga aatccgaaga acgagccggt gatcgcactg tcgccgatcg gcgccgcacc
2036101 tggttggtgt tacggatgaa tccgcagcga aatgtggctg cggtggcgtg tcgtgactcg
2036161 ttggcgtcga cgctggtggc agccaccgag cggttggtcc aggatctgga tgggcaaagt
2036221 tgtgcggccc ggccggtgac ggccgatgag ctgaccgagg tcgacagcgc cgtgttggct
2036281 gacttggaac cgacatggag tcgccccggt tggcgtcacc tcaagcattt caatggttat
2036341 gcgaccagtt tttgggttac gccgtcagac atcacgtcgg agaccttgga tgagctgtgt
2036401 ctgccagata gccccgaagt cgggacgacc gtggtcacgg tgcgtctgac cactcgggtc
2036461 gggtcgcccg cgctatcggc atgggtgcgt tatcacagcg acacgcgcct gcccaaggag
2036521 gtagcggccg gactcaaccg gctcaccggt cgccagttgg ccgcggtgcg tgccagcctg
2036581 ccggccccga cgcaccgtcc actcctggtc atccccagtc ggaacctgcg tgaccacgac
2036641 gagctcgtgc tgccggtggg ccaggaactc gagcacgcga caagctcgtt tgtggggcaa
2036701 tgacacgccc gcaggccgcc gccgaagatg cccgcaacgc catggtcgcc ggtctgctgg
2036761 catcggggat ctccgtcaat ggactgcagc ccagccataa cccgcaggtg gccgcccaaa
2036821 tgttcaccac ggcgaccagg ctggatccca agatgtgtga tgcctggctg gctcggctgc
2036881 tggccggcga ccagagcatc gaagtgctcg ccggcgcatg ggctgcggtg cggactttcg
2036941 gctgggaaac ccgccgcctc ggcgtgacgg atctgcagtt ccgccccgag gtgtccgacg
2037001 ggctattcct gcgactggcg attaccagcg tagattcgct ggcctgcgct tacgcggcgg
2037061 tcctcgccga ggccaagcgt taccaggagg cggcagagct gctcgacgcc accgatcctc
2037121 gccatccgtt cgacgccgag ctggtgagtt acgtgcgggg cgtgctgtac ttccgcacca
2037181 aacgctggcc tgacgttctt gcgcagttcc ccgaggcaac gcagtggcgt caccccgagc
2037241 taaaggccgc gggggcggcg atggccacca cggcgctggc gtcgctcggg gtgttcgaag
2037301 aggcctttcg gcgcgctcag gaagcaatcg aaggtgaccg ggtgccgggc gcggctaaca
2037361 tcgccttgta cacccaaggc atgtgcctgc ggcacgtcgg ccgtgaggag gaagctgtcg
2037421 aactcctgcg ccgcgtgtat tcgcgcgatg cgaagttcac cccggcccgc gaggcgctgg
2037481 ataaccccaa ctttcggctg atcctcaccg acccggaaac gattgaggcg cgcacagatc
2037541 cgtgggatcc ggacagtgcg ccaacccgcg ctcagaccga ggccgcccgc catgccgaga
2037601 tggccgcgaa gtacttggcc gaaggggatg ccgagctcaa cgcgatgctt ggcatggagc
2037661 aggccaagaa ggagatcaag ctcatcaagt cgacgacgaa ggtgaattta gcgcgtgcca
2037721 agatggggct tccggtcccg gttacgtcgc gccacacctt gttgctcggg ccgcccggta
2037781 ccgggaagac ttcggtcgca agggctttca ccaagcagct gtgcgggttg acagtgctgc
2037841 gcaagccgct ggtggtggag accagccgca ccaagctgtt gggccggtac atggccgacg
2037901 ccgagaagaa caccgaggag atgctcgaag gggcgttggg cggtgcggtc ttctttgacg
2037961 agatgcacac tctgcatgag aagggctact cccagggcga cccgtacggt aacgcgatca
2038021 tcaacacgct gctgttgtac atggaaaatc accgtgacga gctggtggtg tttggtgcgg
2038081 gttacgccaa agcgatggag aaaatgctcg aggtgaatca gggtctgcgc cggcgctttt
2038141 cgacggtgat cgagttcttc agctacaccc cgcaggagct gatcgcactg acccagctga
2038201 tgggtcggga gaacgaagac gtgatcactg aggaagagtc tcaagtgttg ttgccgtcgt
2038261 ataccaagtt ctacatggag cagagctact ccgaggacgg cgacctgatc cgcgggatcg
2038321 atctgttggg caatgccggc tttgtgcgca acgtggtgga gaaggcccgc gaccaccgta
2038381 gtttccgttt ggacgatgag gatctcgacg ccgtactggc cagcgatctc accgaattca
2038441 gcgaggatca gctgcgccga ttcaaggagt tgactcgcga ggacctggcc gaagggctgc
2038501 gcgctgcggt cgcggagaag aagacgaagt aggcactctt ttcgtcggtg tcactggcta
2038561 ctttgacctg aacagtcggc ggtgggtgag tggtctgtgg ttggcgaatg aggcggggcg
2038621 gggcggagac tggtccagat ggtgtccgtg cacgcggggg agggtgtggt gttcagccgc
2038681 tcagggcggg gtacgtgccg tctcaatccg tgctgtgtcc aaattgttta caattaacgg
2038741 tggtgccaca ccttaaattc caaatgtaaa tatatttgac gtcggtcaaa aatcccacgt
2038801 ttggcacaag tatcggtggc gcgttgccaa gtcattaggc aatcgagcgg actcccgggc
2038861 atggaaatgc gtgtctttcg tttgtgggtg tccggtatcc agacagcatc gcttgcgcct
2038921 cgactacagg tttgctacta aaattcctat gcgccatagt gattgagaag ggccacgccc
2038981 ccttcgtgtg acgcacggcg ggcgacggcg gcgccgtgcc cggcattggt tgggtgtcaa
2039041 tgaggcttca aggatatcta ccaaatttcc cagaaatatt tcacggaggc cgcaatggag
2039101 ctagcattta atcggcgtac ggtcaggcca atatatcgaa acatgagagg aatgatcgat
2039161 gagcgtcaag agtaagaacg gtcgtctcgc cgctcgggta ctggtggcac tggcggccct
2039221 gtttgcgatg atcgcgctga cgggctcagc atgtctggca gagggtcccc cgcttggccg
2039281 caaccctcag ggggcaccgg ctccggtggg tggcactgtg atcgtcgcgc cgatgcacag
2039341 cggcgtctga ccgccccgtt cgggatctgt acgcactttc atccgactgc gcggttgttt
2039401 gttagcgcat cggatgaaag tgtgccgtct cggctgagga aggaccgtcg cgatgctgcc
2039461 gaatttcgcg gtgctgcccc ccgaggtcaa ttcggcgagg gtgttcgccg gtgcggggtc
2039521 ggcgccgatg ttagcggcag cggccgcctg ggatgatcta gcctccgagc tgcattgtgc
2039581 tgcaatgtca ttcgggtcgg ttacgtcggg attggtggtt gggtggtggc agggatcggc
2039641 gtcggcggcg atggtggacg cagccgcgtc gtacatcggg tggctgagca cgtcggctgc
2039701 ccacgccgag ggcgcggccg gtctggctcg ggccgcggta tcggtgttcg aggaggcgct
2039761 ggccgcgacg gtgcatccgg cgatggttgc ggcaaatcgc gcccaggtgg cgtcgctggt
2039821 agcgtcgaac ttgtttgggc agaacgcgcc tgcgatcgcc gcgctcgaat ccttgtatga
2039881 gtgtatgtgg gcccaggatg cagcggccat ggcgggttat tacgttgggg cttcggcggt
2039941 ggccacacag ttggcatcgt ggctgcaacg gctacagagc atccccggcg ccgccagtct
2040001 tgatgcccgt ctgccgagct cggccgaggc accgatggga gtcgtccgcg cggtcaacag
2040061 cgcgatcgcc gccaatgcgg ctgcggcaca aaccgttggc ctggtcatgg gaggcagcgg
2040121 cacgccaata ccgtcggcca gatatgtcga gctcgcgaac gcgctgtaca tgagtggcag
2040181 cgtcccgggt gttatcgcgc aggcgctctt cacgccccaa gggctctacc cggtggtcgt
2040241 gatcaagaac ctcactttcg attcctcggt ggcgcagggt gccgtcattc tcgaaagtgc
2040301 gattcggcag caaattgccg ccggcaacaa cgtcaccgtc ttcggctact cgcagagcgc
2040361 cacgatctcg tcactagtga tggccaatct tgcggcttcg gccgacccgc cgtctccaga
2040421 cgagctttcc ttcacgctga tcggcaatcc caacaacccc aatggcgggg ttgccaccag
2040481 gttcccgggg atctcctttc caagcttggg cgtgacggcc accggggcca ctccgcacaa
2040541 tctgtacccg accaagatct acaccatcga atacgacggc gtcgccgact ttccgcggta
2040601 cccgctcaac tttgtgtcga ccctcaacgc cattgccggc acctactacg tgcactccaa
2040661 ctacttcatc ctgacgccgg aacaaattga cgcagcggtt ccgctgacca atacggtcgg
2040721 tcccacgatg acccagtact acatcattcg cacggagaac ctgccgctgc tagagccact
2040781 gcgatcggtg ccgatcgtgg ggaacccact ggcgaacctg gttcaaccaa acttgaaggt
2040841 gattgttaac ctgggctacg gcgacccggc ctatggttat tcgacctcgc cgcccaatgt
2040901 tgcgactccg ttcgggttgt tcccagaggt cagcccggtc gtcatcgccg acgctctcgt
2040961 cgccgggacc cagcagggaa tcggcgattt cgcctacgac gtcagccacc tcgaactgcc
2041021 gttgccggca gacgggtcga cgatgccaag caccgcaccg ggctcgggta cgccggtccc
2041081 cccgctctcg atcgacagcc tgatagacga cctgcaggtg gctaaccgca acctcgccaa
2041141 cacgatttcg aaggtggccg cgacgagcta cgcgacggtg ctcccaaccg ccgacatcgc
2041201 caatgcggcg ttgacgatcg tgccgtcgta caacatccac ctttttttgg agggcatcca
2041261 gcaagcgctc aagggcgacc cgatgggact cgtcaacgcg gtcggatacc cactcgcggc
2041321 cgacgtggca ctgttcacgg ccgcaggcgg tcttcagctc ttgatcatca tcagcgcggg
2041381 ccgaacgatt gccaatgaca tctcggccat tgtcccctga tcgtgttttg cgtgaacttt
2041441 aaagcgttgt gctgaggtat gttccgctcg cgtgtggggc ggcccgcgcg accacctatg
2041501 catgagcgcc aatggtcgag acaactacct gcgcggtcat cgggcggcca cccagagggc
2041561 atggttctcg ggctgctact ggctcgcgtg cttccatcga gcgtgaatac atgccgccaa
2041621 atcggcagtc ggcgccgctg gcgtgccgct agctgatcac aaagcgccga taccgatgcg
2041681 gctggccata gcaatgccaa tgttggcgaa tagatctcac gcgcggccca agccaacagc
2041741 gaggtgatgg tgatcattct ttacgttgcg attacctcgc cggaacgtga cacgagcaat
2041801 actcgccaac catgatcgcc agatatttgg aacgggtttg ggtccagcgg ccgccaaaaa
2041861 ccgactcgcc gccgtccctg acaactcagc ggcgagaggt gaacacgggt gatttgtcac
2041921 tacgggccgc tgcggttcct gcgctgccag ggggccgcga gtgcgattcc ggcgagccac
2041981 gcgattaggg attaagcgaa atggatttcg ggttgttacc gccggagatc aactcaggca
2042041 ggatgtatac ggggccgggg ccggggccca tgctggccgc cgcgacagcc tgggacgggc
2042101 tggctgttga gctgcacgca acagcggctg gctacgcctc ggagctatcg gctttgaccg
2042161 gggcatggag cggtccttcg tcgacgtcca tggcatctgc agccgcaccc tatgtggcat
2042221 ggatgagcgc caccgcagtg catgccgagc tggcgggcgc gcaagccagg ttggcgatag
2042281 ctgcctatga agctgcgttc gctgccaccg tgcctccgcc ggtgatcgcc gctaatcgtg
2042341 cccaactgat ggtgttgatc gcgacgaaca tcttcgggca gaacacgccg gcgatcatga
2042401 tgactgaggc ccaatacatg gaaatgtggg cgcaggatgc cgccgcgatg tacgggtacg
2042461 ccggctcgtc agcgaccgcc tcgcgaatga cagcgttcac tgagccgccg caaaccacta
2042521 accatggtca gttgggggcc cagtcctccg ccgtcgcaca aaccgccgcc accgcggccg
2042581 gcggcaacct gcaatcggca ttcccgcagc tgctctccgc ggttccccgc gccctgcaag
2042641 gcctggcatt gccgaccgca tcacagtcgg catcggcgac gccgcagtgg gttaccgacc
2042701 tggggaacct gtccaccttc ctgggcgggg cggtcaccgg cccgtacacc tttcccgggg
2042761 tattgcctcc ctccggggtg ccatacctgt taggcattca gagcgtcttg gtaacccaaa
2042821 acgggcaggg ggtaagcgcc ttgcttggca agatcggggg gaaaccaatc accggagcgt
2042881 tggctccgct ggccgaattt gctttgcata caccaatttt gggttcggag ggcttgggtg
2042941 gtggatcggt ttccgcgggt attggccggg caggcttggt cggaaagcta tcggtgcctc
2043001 agggctggac ggtggccgcc ccggagatcc catcgccggc ggcggcgttg caggcgacgc
2043061 gcctggccgc cgcgccgatt gcggccaccg acggcgcggg tgcgttgctc ggtggcatgg
2043121 cgctgtcggg cttggctggc cgcgctgccg ccggttctac cggccacccc atcggcagcg
2043181 ccgcagcacc cgccgtcggt gccgctgccg ctgccgtcga ggacctggcc accgaagcca
2043241 acatcttcgt gataccggcc atggacgact agcgccatgt cacgggagag aaggttgtcg
2043301 acacttttgc gaccagcgcc ggttcggtat gtggccaccg gggctgccaa tggggttacg
2043361 gcccgttaag gagggatgcg gtaatggatt tcggggtgtt accaccggag atcaattccg
2043421 ggcgcatgta tgccggtccc gggtcgggtc cgatgctggc cgcggcagcg gcctgggacg
2043481 ggctggccac cgaattacag tccacggcgg ccgactatgg ctcggtgatc tcggttctga
2043541 ccggcgtgtg gtcgggacag tcgtcgggga ccatggcggc tgcggccgca ccgtatgtgg
2043601 cgtggatgtc ggccacggcg gcgctcgctc gggaagcggc cgcccaggcc agcgcggcag
2043661 cggcggccta cgaggcagcg tttgcagcca cggtgccgcc gccggtcgtc gcggccaacc
2043721 gcgccgagct ggcggtgttg gcggcgacca acattttcgg tcagaacacc ggtgcgatcg
2043781 cggccgccga agcccgctat gcggaaatgt gggcgcaaga cgcagccgcg atgtatggct
2043841 atgccggctc gtcgtcggtg gcgacccagg tgacgccatt tgctgcaccg ccgccgacca
2043901 ccaacgcggc cggactggcc acccaaggcg ttgcggttgc ccaggctgtc ggcgcgtcgg
2043961 ccggcaacgc gcgctcactg gtgtccgagg tgctggaatt cctggcaacg gccgggacga
2044021 actacaacaa gacggtggcc agcctgatga acgcggtcac cggggtgccg tacgcatctt
2044081 cggtgtataa cagcatgctc gggcttggct tcgctgagtc aaaaatggtc ctgccggcta
2044141 acgacaccgt aatatcgacc atcttcggca tggtgcagtt ccagaagttc ttcaatccgg
2044201 tgacgccctt caatcccgat ttgatcccga aatctgctct aggggccggg cttggcctgc
2044261 ggtctgcgat ctcgagtggt ctgggctcga ccgcgccagc gatatcggcg ggtgcgagcc
2044321 aggccggctc ggtcgggggg atgtcggtgc cgccgagctg ggcagcggcc accccggcga
2044381 tccggacggt tgccgctgtg ttctcgagca ccggacttca ggctgtcccg gcggccgcaa
2044441 ttagcgaggg cagtctgctc agccagatgg ccctggcgag tgtggccgga ggggcccttg
2044501 gcggcgccgc tgcacgcgcc actggtggtt tcctcggcgg aggccgagtc accgcggtca
2044561 agaaatctct caaggacagc gactcaccgg acaagctgcg gcgggtggtc gcgcacatga
2044621 tggagaagcc cgaatcggtg cagcactggc acaccgacga ggacgggctc gatgatctac
2044681 tcgcggaatt gaagaagaaa ccgggcatcc acgccgtgca catggccggc ggcaacaagg
2044741 ctgaaattgc accgacgata tcagaatcgg gctagggcag ggttagggcg tgtcttccaa
2044801 ttgataggcc ccgaggcaga cacgagtcgc cagaccgcac cattgcttga gttggttgat
2044861 gcccttgaga tcggaacccg aatcccacag caggagaatt agtttcgtcc ccagaccggc
2044921 ggctacggct gcccgttctg cccaggcaaa ccgatcaatc cgcccttgcc gccttggccc
2044981 ccgggtgcgg gtgggacacc atctccgccg tcgccaccgg taccgatcag cagggcggcg
2045041 ttaccaccgt caccgccggc accgccagtg cccgcactgc cgccggttcc gccggcccca
2045101 ccggtaccgc cacttccccc gggtccgccg ttgccgatcc ccaggccgct tgccccgcct
2045161 tggccaccat cgccgccgtt gccgccgtcg ttgcccgacc cgccgacgcc gccggccccg
2045221 ccgatgccgc cggccccgcc gctaccgaac agtaggcctc cgctgccgcc cgcgccaccg
2045281 tcgctgccgt cacctccggc ttcctgaata atgttgccta ctccggtccc accggtcgcc
2045341 ccattccctc cggccccgcc gttgccgatc agaatggcgg cgccaccctg gccggcgctg
2045401 ccttcgaagc cggtacctcc gccgctgccg gcgttaccac cgttgccgcc attgccgtat
2045461 agcaccccac cttggccgcc gtcaccccct gatgcaccaa attgaatgct gaggctgccg
2045521 gccccaacgt caccaccgtt gccaccgtca ccgccgtgac caaacaaccc aaaaccctgg
2045581 acactaatcg gtccgaagtt aacggcacct acccagccgc caccgccagc agagccgcca
2045641 aagcccgcaa atccgttggt gcctgcgtca ccgccctgac ccccgttgcc gccggacgcg
2045701 ccgctgccga acaaccaccc gccgttgccg ccgtcgccgc ctgagccacc gaccccgccg
2045761 ctcccgccga agatggtagt acccagcgca gacccggccg ctccattccc gccgttgcca
2045821 ccggccccgc cgttgccgac taggcccgcg tcaccgccgt taccggctat cccggccgaa
2045881 ccgccggaag cgccgttcat gacgcccgtt tgagtggagt cggtgccgcc gccggcgccg
2045941 ctgtccccac cttgcccccc gttgccgatc agccacccgc cctgggcgcc gttgcccccg
2046001 ttgcctccta atccgccgct gccggccgaa tctccggctg tgtcattagt gccttgtcct
2046061 cccatgccac cgaccgagcc gttgccgccg ttgccgaaca acagtccacc gcgaccaccc
2046121 gaacccccgt ttccgccggc gcccccatcg aagcctgccg acgcaccccc gggcgctgtg
2046181 gcgttgcccc cgtttccgcc ggccccacca tgtccaccgt gaccatagat ccatccaccg
2046241 gcgccgccgt tgccgccgga cccgcccgct ttcccgggtt gaccggctgc gccgttggca
2046301 cccgccccgc cctggccgcc attgccgccg ctaccccata gcccagccga cccgccgttg
2046361 ccgccatttt ggcccgtccc gccggacccg ccgttgccac cgttgccgta tagccatccg
2046421 ccatcgccac cgttttgccc ggttcctgcg accccgttgg caccgttgcc gataagcgga
2046481 cgcccggtca gcgtctgcac gggtgaattg atggcatcga gggcggtttg gcccacgatt
2046541 tgcaatggtg acgagttggc tgcctcggcg ctggcgtact gggccgcccc cgcgctcatg
2046601 agctggacga actgctcatg gaatgcgacc gcgtgggcac tgagctcctg gtatgcctgc
2046661 ccgtgcgttg cgaacagcgc cgcaatcgca gccgacacgt cgtcagcgcc cgcaggcagt
2046721 aacgccgtta tcgggaccaa cgcttcggcg ttggcccggc taatcgccga accaatagtt
2046781 gctaggtcct ttgccgctgc atcgacaaac gccggcgcca cgatcatctg cgacgtccac
2046841 acctcctggc cgttgtcgtc gcatggggaa tccatacgac cgccaaagga attttggaac
2046901 cgacgccaac gttacagttt tgcggacccg ctatggggtg cattcaccag attcactggc
2046961 aacgatgtga accccgtgtc accccaagcg gggtcaatcc actgattact ctctagccca
2047021 aactatttcg cgctgacgct ggttttagtg atctggtggg ggcaatagac atgcgcggag
2047081 atcgcagcga acttgcaaca accgtccatc gaaaacccgg gattgcgggt ccgcagctcg
2047141 ttgacgacct gaagacccga ttcgccgctt tcgactaacg cgcatacggc cttgcccgat
2047201 gctatggctt gatccgggtg gctgtaggta atgcctgccc gctctagcga ggcaagaaag
2047261 accgcgtcgt caccgctggg ccccgcgtgg gccggaaccg ccaagccgat catcaacgga
2047321 atgctgagta gcgttgacac aactctcata gacaacgatt ctcccggaat tgcgcttctc
2047381 ttgcggtgca accggttacc gcgtcattcc aatacgttac ggctgcgcta acttcccgtc
2047441 tcagggtgtt cgggttgcgc tggacctgaa ggtcgtctgc tgaccggcgt tgtctgctcg
2047501 ctggctaaca gccgatcttg atagcctccg gggcatcgga tgagtcaagc cgttgggttg
2047561 acgcgcgtcg ctacgagtgt cacgattacc cttgcaagca cctcgctagg tgaggcgtct
2047621 gcgcggatat aggccactga cctcgaacgt cgaaagacgc ccagggtcag gacagctctt
2047681 cccggcttaa gggttgagcc caagtggctt ccggctggac cggccggata cgccgtgtgg
2047741 tgccaaagct ctgacgagag gggtgccgag ttcggtggtc tgctgggctg tcatcccttt
2047801 gtgctgtgca tcggcatccc cgtgtgcccc ggccgtgagg aggtgagagc gaaatgagtc
2047861 ccggcgatag tccgtatccg agatcgacga ccgtttcgtt ccgatccgac cccggcgccg
2047921 ttttcgcact ctgaatcggc cttccggttc gaaatccgtt atttcgcaag ctcgttgctt
2047981 cgcggccttg tgtgagtgac gttcacggga agtagccacg acagaagcgg tcataggcct
2048041 ccgggttcgg tcgtctgtca ggagaagacc catggcgttt gttcttgtct gtccagatgc
2048101 gctggccatc gcggccggtc agttgcgcca tgttggatcg gtgatagccg cgcggaatgc
2048161 ggtcgcggca ccggcaactg ccgaattggc cccggcggcc gctgacgaag tatcagcttt
2048221 gactgcaaca caattcaact tccatgccgc catgtaccaa gcggtcggcg cccaggcgat
2048281 cgccatgaat gaggcgttcg tcgcgatgtt gggcgccagc gcggattctt acgcggctac
2048341 cgaagccgcc aacatcattg ctgtgagcta acgaggagat caacgatgac tgccgcactt
2048401 gacttcgcca cgctaccgcc cgaaatcaac tcggcgcgta tgtattccgg cgcgggctcg
2048461 gccccgatgc tggccgcagc gtcagcctgg cacggcttgt ccgcagaact gcgcgccagc
2048521 gcactgtcat acagctcggt gctttcgacg ctgaccggtg aagaatggca cggtccggcg
2048581 tcggcatcga tgacagccgc ggccgccccc tacgtggcct ggatgagcgt caccgccgtc
2048641 cgggccgagc aggccggggc acaggcggag gctgccgctg cagcgtacga agccgcgttc
2048701 gcagcaacgg tgcccccgcc ggtcatcgag gccaaccgcg cccagctcat ggcgctgatc
2048761 gccaccaatg tgctaggcca aaacgccccc gcgatcgcgg ccaccgaggc ccagtacgcc
2048821 gaaatgtggt cccaggacgc gatggccatg tacggctacg ccggcgcctc ggcagccgct
2048881 acccagctga ccccgttcac cgagccggtg cagactacca acgcgtccgg cctggcggcc
2048941 cagtcggctg cgattgccca cgccaccggc gcctcggctg gtgctcagca aacgacgctg
2049001 tcgcagctga tcgccgccat accgtctgta ctgcaaggac tttcgtcatc gactgcagcc
2049061 acgttcgcgt cggggccgtc cggattgctg ggcattgtcg ggtctggatc ttcctggctc
2049121 gacaaactct gggcgttact ggaccccaac tccaatttct ggaacacgat agcttcgtcc
2049181 ggactgttct tgccgagtaa cacgattgcg ccctttttgg gtctactcgg cggcgtggca
2049241 gctgcggatg cggccgggga tgtgttggga gaggccacca gtggcgggct cggtggcgcg
2049301 ctggtggcgc cgcttggctc agcgggcggg ctaggcggca ctgtcgcggc cggcctgggc
2049361 aacgcggcca ccgtcggaac cttgtcggtg ccgccgagct ggacggcggc cgcaccacta
2049421 gccagcccct tgggctccgc gttgggaggc acaccgatgg tggcaccgcc cccagcagtg
2049481 gcggccggca tgcccggaat gcctttcggc accatgggcg gtcaaggctt cgggcgtgcc
2049541 gtgccccagt atggcttccg ccccaacttc gtcgcacgac cgcccgccgc cgggtgatcc
2049601 cgtagggggt gggttccctg gaaagcgcca gggtcacgat ggcgcagccg aatagccgac
2049661 agtgcttttc tctgcgaata ccggagttgg tcgcgcgaaa tcatttccgt ttagcgcgtt
2049721 caccagcgca ggcgggccag gctcaataag cggaaatttc tcgggcgaag cacccgtgca
2049781 gcagcgcaaa tagatgggat cggcaggacg tagacattgg gatatctggt gaagttcata
2049841 agagcttgac cagttggtgg gcagaactac gcgagcgtga ttagcatggc ggccatcgag
2049901 gggaccggag gtcagggatg ttggatttcg gggcgctacc accggagatt aattcggggc
2049961 gaatgtacgc gggtccggga tccggaccgt tgctggccgc cgcagcggcc tgggatgcgc
2050021 tagccgccga gttgtactcc gcggcggcgt cctatggctc aacgattgag ggcctcaccg
2050081 tagcaccgtg gatgggtccc tcctcgatca cgatggccgc cgcggtcgct ccatatgtgg
2050141 cgtggattag cgtcaccgcc ggccaggccg aacaggcagg ggcccaggcc aagatcgctg
2050201 cgggcgttta tgagacggca tttgcggcaa cggtgccgcc accggtaatc gaggccaacc
2050261 gcgctttgtt aatgtcgctg gtcgccacga acatcttcgg gcagaacaca ccggcgatcg
2050321 cggccaccga ggcccactac gcggagatgt gggcgcaaga tgcggccgcg atgtatggct
2050381 atgccggctc gtcggccact gcgtcgcagt tggcgccgtt cagcgagccg ccgcaaacga
2050441 ccaatccgtc ggcaacggcc gctcaatcag ccgtcgtcgc ccaggccgcc ggcgccgcgg
2050501 ccagctctga catcacagcg cagctgtccc agttgatcag cctgctaccc agcaccttgc
2050561 aaagcctggc gacaacagcg accgcgacgt cggccagcgc tggttgggac accgtcctgc
2050621 aaagcatcac cactatcttg gcgaacctca ctgggccgta cagcatcatc gggctgggcg
2050681 ctatacctgg cggctggtgg ctgacgttcg gccagatcct cggcctagcc caaaacgccc
2050741 caggtgtggc cgccctactg ggcccgaaag ccgccgccgg cgcgttgtcg ccattggcgc
2050801 cgctacgggg cgggtatatc ggagatatca cgcctctcgg tggtggggcc acagggggca
2050861 tcgcccgtgc gatctacgtc gggtcgctct cggtcccgca gggctgggcc gaggccgcac
2050921 cggtgatgag ggcggtcgca tcggtattgc cgggcaccgg cgccgccccc gccctggccg
2050981 ccgaggcacc aggtgccttg ttcggcgaga tggccctgtc gagtctggcc ggacgcgcgc
2051041 tggcaggaac cgcggtgcgc tctggtgccg gagctgctcg cgtcgcaggc ggttccgtca
2051101 ccgaagacgt cgccagcacg accaccatca tcgtcatacc cgcggactga caggactttc
2051161 gagatggcac ttgaactggg tgttagcccc caccggagag gagagaagga cggtgtcatc
2051221 gccactgtgg ccggtggctg gcggccagcc agttagcggc cggttgagga aaggtgtggc
2051281 aatggatttc ggattgcagc caccggagat cacctccggg gagatgtacc taggtccggg
2051341 cgccggtccg atgttggctg cggcagtggc ctgggatggg ttggcggccg aattgcagtc
2051401 catggcggcc tcctacgcct cgatcgtcga gggcatggcg agtgagtcat ggttgggtcc
2051461 gtcgtcggcc ggtatggccg ctgcggccgc accatatgtg acctggatgt cgggtacctc
2051521 ggcacaggcc aaggcggccg ctgaccaggc cagagccgcg gtggtcgcct acgaaaccgc
2051581 gttcgcggcg gtggtgccac cgccgcagat tgcggccaac cgcagccagc tcatatcgct
2051641 ggtggcgacc aacattttcg gacaaaacac cgccgcgatc gcagccaccg aagccgaata
2051701 cggcgaaatg tgggcccagg acaccatggc gatgttcggc tatgctagct cctcggcgac
2051761 cgcctcgcgg ctgaccccgt tcactgcacc gccgcagacc accaacccgt ccggacttgc
2051821 cggccaggcg gccgcaacgg ggcaagcgac cgccctagcg agcggcacca atgcggtgac
2051881 aaccgcgctt tcgagtgcag cggcgcagtt tccgttcgac atcatcccga ccctgctgca
2051941 gggcctggcc acactcagca cccaatacac ccaactcatg ggccaactca ttaacgccat
2052001 cttcgggccg acgggcgcaa cgacctatca gaacgtgttt gtcaccgcag ccaacgtcac
2052061 caagttcagc acgtgggcca acgacgccat gagcgcgccc aacctgggaa tgacggagtt
2052121 caaggtgttc tggcaacccc cgccggcgcc cgagatcccc aaatcgtcgt tgggtgccgg
2052181 acttggcctg cggtcagggc ttagcgcggg cctggcccac gccgcatcgg cgggtctggg
2052241 tcaggcgaac ctggtgggag acctgtcggt accgcccagt tgggcctcag ctaccccggc
2052301 ggtcaggcta gttgccaaca cattgccggc caccagcctg gctgcggccc ccgcgacaca
2052361 gatcccagca aacctgctcg gtcagatggc tctggggagc atgaccggag gtgccctcgg
2052421 tgccgccgcc cccgccatct acacgggcag tggcgcccgg gcccgcgcca atgggggaac
2052481 gcccagcgct gagccggtca agctggaggc tgtcatcgcg cagctacaaa agcaaccgga
2052541 cgcagtgcga cactggaatg tcgataaggc cgatcttgat ggcctgctgg atcgattgtc
2052601 gaaacagccc ggcatccacg cggtacacgt gtcgaacggc gacaaaccca aggttgcctt
2052661 gcccgatact cagttgggtt cacactgaac gtgattcgaa atccacactg atactggagg
2052721 tgattaccgg ctgaagcaaa gcgcattgga aatccaggct tagaccattg ccatgtggcc
2052781 gtgagattcg tcacgtcttg acatccgcgt ccggcgggtc accttcgacc gcggtcaatg
2052841 tcattggtag gtaagggctt tgctgtactg atggccgaat tttgactcga aaagtatgtc
2052901 gggccctcgc agcagatctg ccgcaggacg cgatgcaatt acaacgcacg atgggacaat
2052961 gcagacctat gagaatgcta gtagcgctcc tgctgagcgc cgccaccatg atcggcctag
2053021 ccgcacccgg gaaagccgat ccaacaggcg acgatgccgc cttccttgcc gcgttggacc
2053081 aggccggcat cacctacgct gacccaggcc acgccataac ggccgccaag gcgatgtgtg
2053141 ggctgtgtgc taacggcgta acaggtctac agctggtcgc ggacctgcgg gactacaatc
2053201 ccgggctgac catggacagc gcggccaagt tcgctgccat cgcatcaggc gcgtactgcc
2053261 ccgaacacct ggaacatcac ccgagttagc ggggcgcatt tcctgatcac cgcggtggtg
2053321 cgcggtggtg tggtgcgtcc gagggggttg cgatgcaccc ggttcgccta ggctcaaact
2053381 gctgttaacc tgcgcgtggt tggctgccgt ggccgtcttg cgatcgggaa ggactcggcg
2053441 tcatgcaaac gctgactgtc gccgatttcg ctctccggct ggccgtcgga gtgggttgcg
2053501 gggccattat cgggctcgag cgccagtggc gggcgcggat ggctgggttg cgcaccaacg
2053561 ctctggtggc gaccggtgct accttgttcg tgctgtacgc ggtcgccacc gaggacagca
2053621 gccccacccg agtggcgtcc tacgtggttt ctggaattgg attcctgggc ggcggggtca
2053681 tcctgcggga ggggttcaac gtccgcggtc tgaacacggc tgccacgctt tggtgctcgg
2053741 ccgcggtcgg agtgctggcc gcctccgggc atctggtgtt caccctgatt ggcaccggaa
2053801 ccatcgtcgc tgtccatctc ctggggcgcc cacttggccg gctggtcgac cgcgacaacg
2053861 ccgtcgaaga cgaagggctg cagccctacc aggtacgggt gatttgtcgg cccaaagcag
2053921 agacctatgt acgtgcccat atcgtgcagc gcaccagcag caacgacatc acgctgcggg
2053981 gtatacgcac ggggccggcc ggagacgaca acatcacgtt gacggcccac ctattgatgg
2054041 ttggccatac cccggccaag ctagagcggt tggtggcgga actgtcgctg cagccgggcg
2054101 tttacgctgt gcactggtat gccggtgagc acgcgcaggc cgaatgaccc acgacactag
2054161 gggcggggct gtactcgcgg cgcggccgca gccagcaagt ctgcccgact gccgttcagc
2054221 ggcgggtaga tccgccgggt attgattgac tgcttggtgg tcttggccgg tgcgccctgc
2054281 gataccactt tgcgttccca tccctcggtg tacaccgcgc ccgccgatcc tagatcgaga
2054341 accgtgacat accaagggat ccgaagagcc agcaacggtt ggtcgaacag atcgttgatg
2054401 acgttgcagc cggcatagcg gcccatcggg cgcccatgct gacacgacat gaccgacagg
2054461 tgctcgtcat ccatccgggc cgcggccaca tcgccagcag caaacatcgc aggcaccccg
2054521 atcacccgca ggtagtcgtc gacttgcagg cgtcccagcc gatcacgggc taccggcagc
2054581 tgctcggtca ggcggctggc ccgcatgccg gcgcaccaca ccacggtggc cgctgccagc
2054641 cgttcccccg atgacagcgt tacaccgccc gggctgacgg cggcaacgct cacgccggtt
2054701 ctggtctcga cgccgttgtc caacagcgcc tgttcgatca ccggccgcgc cgataaaccc
2054761 atatcggagc cgacgaaggg gttgtggtcg atgagtacca cgcggggggt gacaccatca
2054821 ccacgggcga acaacgcgtg cagtcggccc ggcaactcgc aggccgtctc gataccggtc
2054881 agcccggcac cgacgaccac gacggttgcc gccgccgatg tcagcggccc gccggccagt
2054941 ccttgcagat gctgctgtag cctgaccgcg ccgtcgtacg tgtcgacatc aaaaccgaac
2055001 tctgccagtc ctggcaacgc gggtttgacc acgtgactgc ccgacgcgag gaccagtcgg
2055061 tcatagctat atgaggcacc ggtcgacgtg gtgacgcggc ggccgtcggc gtcgatcgcg
2055121 gtcacctcgg cggtgacatg cgcaacgccg gcagggccga gcacgtcgcc gagcgggatg
2055181 cggcaggcgc tcagatcagc ctcatagttg cgaacccgga tatcatgaaa cggtttgttg
2055241 ctcaccacca tgacgtcgac cgtgcccgct aggacggcga gctcgtcgag tcgtcgggcc
2055301 gcaccgagcg ccgcccacag gcccgcgaac ccggagccga tcaccaccac ccgggtcaac
2055361 ggctaaacac ctgacgactc tggggtatcg ccgccgccgc gtggcgaccg ggcaggaaca
2055421 tccacacgtg ccaacctcct tcgagcccgg gccatccgat aaccccgtta gccgtcgcga
2055481 gcttacagaa ggtgcaggca tcgggattga gtgcatcatg ggataccggt gaataccgtc
2055541 agccggggca gccagggtag gggacacccc ccgctcgggc tgccagcgga gtatcgagcg
2055601 gatcgccatc ggcgtagcag ataccgggtc agagcagcgt acgctggcac attcggcttc
2055661 ggctcgctgg ttagcgattg ttagttgcac gcccagttga cgatccgccc gccttcgagt
2055721 cggttcacgg cgtcgtcttc tgccgcgcgg cgcgtgagtc cggttccgcc ttggtatttc
2055781 gagccgttgt aggcgaccgc gccgcacctg gtgaagcgac taaccacttt gcaagtcttg
2055841 tcaccgcact tttctagtgc gacttgctct gctcgcgccg gtgtgcgctg gtgccacgct
2055901 ttgcccgacg cgccgctggg ggcataggca atcgccccgt aatggataat cggagggata
2055961 ggcaacccgg caatttccga catcatgact tccgacatcg aaccgttggc gagatgggcg
2056021 tccaccgtcg gaaccagcag gatgcccagc ccgagagcag cccctaggcc ggcggctgcc
2056081 atcgcggttc ggcgtcggag gtttgtgatc atgtcctgcc ccctttctgc ggtcggtaat
2056141 ccagcggttt gaaagggttg agccgactta cgcgcagtgg atgcgtcgaa gggtcaatga
2056201 ggctgggtac tgagacggcc acggttggaa gcccggcgcc ctggccgatg atcgatcagg
2056261 tcatcgctgt atggaggctg cccacccacg gtgctcggtt cggtccggga ttctggcgct
2056321 tgtgtgtcat gtgcccaagt gtgcgataaa tatacctgac ccgggtaggg cataaagtct
2056381 ctaacagcac cgaccggata gggaacaacg gccttcgggc aagcggcttc actgtcaagt
2056441 cgtcacctgt cacgcatgcg agtcgtagcc tgtctgatgt ggatgccgtc gccggattct
2056501 tctcagcgct gcccgaggaa atgcgggacc cggtactgtt cgccattcca tgttttctat
2056561 tgctgctgat tctcgaatgg acggcggccc gcaagctgga aagcatcgag accgctgcta
2056621 ccgggcagcc acggcccgcc tcgggcgctt acctcacccg cgactcggtg gccagcatct
2056681 cgatggggct ggtttcgata gccaccaccg ccggctggaa gtcccttgcc ctgctcggtt
2056741 atgccgcaat ctatgcctac cttgccccct ggcagctgtc cgcccaccgg tggtacacct
2056801 gggtgatcgc gatcgttggt gtcgatctgc tgtactactc ctatcaccgc atcgcccacc
2056861 gagttcggct gatctgggct acccaccagg cgcatcactc cagcgaatac ttcaacttcg
2056921 ccaccgcgct gcgccagaag tggaacaaca gcggcgagat tctcatgtgg gttccgctgc
2056981 cactgatggg gcttccccct tggatggtgt tctgcagttg gtcgctgaac ttgatctacc
2057041 agttctgggt gcacaccgag cggatcgaca ggctgccgcg gtggttcgaa ttcgtcttca
2057101 ataccccgtc gcaccaccgg gtccaccacg gaatggaccc ggtgtatctg gacaagaact
2057161 atggcggcat cctcatcatc tgggaccgcc tgttcggtag ctttcagccg gagctattcc
2057221 gaccgcatta tggcctgacc aagcgggtcg acacgttcaa catctggaag ctgcagaccc
2057281 gcgagtacgt ggcgatcgtg cgtgactggc ggtcggcaac acgtctgcgg gatcggctgg
2057341 gctacgtctt cggaccgccg ggctgggaac cgcgcaccat cgataaatcc aatgccgccg
2057401 cctccctggt cacgtctcgg taacgtcgcg acccgacatt gcgaaagtat taccgtcggg
2057461 ttttggtacg ccttagccgt aaccggcggc gggcgatgcg cttggccccg acggatggga
2057521 gttcaaggtg gtccgcctgg taccacgcgc attcgcagcg acggtcgccc tattggcggc
2057581 cgggttttcg ccggcgaccg ccagtgccga tccggtcttg gtgttccccg gcatggaaat
2057641 ccgtcaggac aaccacgtct gcaccctggg ctacgtcgac ccagctctga aaatcgcgtt
2057701 taccgcgggg cattgtcggg gcgggggagc ggtcaccagc cgggactaca aggttatcgg
2057761 ccatctcagg gccatccggg acaacacacc cagcggctcc accgtggcca cgcacgagtt
2057821 gatcgccgac tacgaggcga ttgtgctggc tgacgacgtc acggcaagca acattttgcc
2057881 gagcgggcgt gcactggaat ccagaccggg tgtggttctt cacccgggcc aagcggtctg
2057941 ccatttcggc gtcagcacag gcgaaacctg tgggaccgtc gaaagcgtca acaacggctg
2058001 gttcaccatg tcccacggcg tgctcagtga gaagggggat tcggggggcc cggtctacct
2058061 ggcccccgat ggcggccccg cgcagatcgt cgggatcttc aacagcgtct ggggcggctt
2058121 tcccgcggcg gtgtcctggc ggtcgacgtc cgagcaggtt cacgcggatc tcggcgtgac
2058181 gccccttgct tagcaagcac cccgttagcg gccaccaggt tgatcgccgt gtgtttgcta
2058241 gagcggtgat ctcggttgtg tcagacttgc cgcgtgggca aacgccggga tgcgagggaa
2058301 cagatcgagg cgaaaattgt cgaactcggc cgtcgccagc tgctggatca cggcgcggcc
2058361 gggttgtcgc ttcgggcaat tgcccgcaac ctgggcatgg tgtcctcggc cgtataccgc
2058421 tatgtgtcca gtcgtgatga gctgttgact ttgctgctcg tcgacgccta ctccgacctg
2058481 gccgataccg tggaccgagc ccgcgacgac accgtcgccg actcgtggag tgacgacgtc
2058541 atcgcaatcg ctcgagcggt gcgcggttgg gcagtcacta accccgcccg ctgggccttg
2058601 ctatacggta gcccggttcc tggttatcac gcgccgcctg accgtaccgc gggcgtcgcc
2058661 acccgcgtgg tcggagcgtt cttcgacgcg atcgccgcgg gaatcgccac cggagacatc
2058721 aggttaaccg atgacgttgc gccgcagccg atgtcatcgg acttcgaaaa gatccggcag
2058781 gagttcggct ttcccggcga cgatcgtgtc gtcacaaagt gctttctgct ctgggcgggc
2058841 gtggtgggcg cgatcagcct ggaggtattc ggtcagtacg gggccgacat gctaaccgat
2058901 ccaggagtgg ttttcgatgc ccagacacgg ctgctggtgg ccgtgctggc cgagcattga
2058961 agctgctgca atcggcgtgt ccagccggaa ttagaacgtg ttcactcaag gctaccagtg
2059021 ctgacacttg cggtggtggc aaatgcaatc tgagcccttt ctggcctctg gcaagctggg
2059081 ctgtcctgcg agacgctcat ccttctcgtt ctgtcgctga tacagatcgc aggggttacc
2059141 cccggaccta gaagccgccg aaacggctct caccggcttg ttaggcgtcc ggaagcggat
2059201 tcggatgcgc gatgtccgct ttgcgcacga cacctgtagc agtctgggca agcccgcgat
2059261 gtcgtcgcga gtatctcgtt gagctatctc ggagagatgc ccttcgagtt agtatcgtcg
2059321 gttcgtgtag agaatatcta tagtgacttt tgcgggactg tgggccgggt ctacaccagg
2059381 ggctcgaagc cgcattggcc gaagcaagcg gaggtgcaag tgccgacatg agcggcgcca
2059441 atgagccgcg ccggcgacga tgcagtgggg gtaccgcccg cttgcggggg acgaagcgat
2059501 gacgaggagc ggcgccaatg agccgcgccg gcgacgatgc agtgggggta ccgcccgctt
2059561 gcgggggacg aagcgatgac gaggagcggc gccaatgagc accgacatac ccgccaccgt
2059621 tagtgcggag accgtgacgt cctggtcgga tgacgtcgat gtaacggtga ttggtttcgg
2059681 catcgccggc ggttgcgcgg cggtcagcgc ggccgccgcc ggcgcccggg tactggtgct
2059741 cgaacgtgcc gccgcggcgg gcggcaccac cgcgcttgcc ggggggcact tctacctggg
2059801 gggcggaacc acggtgcagc tggcgaccgg tcatcccgat tcacccgagg agatgtacaa
2059861 gtacctggtc gcggtctccc gagagcccga tcacgacaag attcgcgcct attgcgacgg
2059921 cagcgtcgag catttcaact ggttggaggg cctgggtttt cagttcgagc gtagttactt
2059981 tcccggcaag gctgtgattc aacccaacac cgagggcttg atgttcaccg gaaatgagaa
2060041 ggtgtggcca ttcctggagt tggcggtgcc ggcaccgcgc gggcacaagg tacccgtgcc
2060101 gggcgacacc ggcggtgccg ccatggtgat cgacctgctg ctcaagcgag ccgcaagcct
2060161 ggggatacag atccgctacg agacgggcgc caccgagctc atcgtggacg ggaccggcaa
2060221 ggtaaccggg gtgatgtgga agcggttctc cgaaaccggt gcaatcaaag cgaagtcggt
2060281 aatcatcgcg gccggcggat tcgtgatgaa cccggacatg gtggccaaat acactccgaa
2060341 actggccgag aagccgttcg tgctgggcaa cacctacgac gacgggttgg gcatccggct
2060401 gggtgtatca gccggcggcg ccacccaaca catggaccag atgttcatca cggctccgcc
2060461 gtacccgccg tcgatcttgc tcaccggcat catcgtcaac aaactcggac agcggttcgt
2060521 cgccgaggac tcctaccatt ccaggaccgc tgggttcatc atggaacagc cagacagcgc
2060581 ggcgtatttg atcgtcgacg aagcccacct ggagcacccc aagatgccgc tagtcccgtt
2060641 gatcgacggc tgggaaacgg ttgtggaaat ggaagccgcg cttggcattc caccgggcaa
2060701 cctggcggcg acgctggacc gctacaacgc ctacgccgcg cgcggcgcag atcccgattt
2060761 ccacaagcag ccggaattcc ttgcagcaca agacaacggg ccgtgggggg cgttcgacat
2060821 gtcgctgggc aaggcgatgt atgccggatt cactctgggc gggctggcca cgtcggtgga
2060881 cggtcaagta ctgcgcgacg acggcgcggt ggtggccggc ctgtacgcgg tcggggcatg
2060941 cgcgtccaat atcgcccagg acggcaaggg atatgccagc gggacccagc tgggtgaggg
2061001 gtcgtttttc gggcgtcgcg ccggagcgca tgcggcagcc cgagcgcagg gcatgtaagc
2061061 ctcctcgcgc cgcgactggg aatcctgcga cgcgacacgc cgacaaggcg tcgtgagatt
2061121 cacagtcgca gcgcggcttc aggtaagacg ccgggagcgc ggtagccggc ctcccggcta
2061181 cggtaacccg ttcatcccgt tcttacccaa cagcccgccg gcaccgccgg tgcccgcgct
2061241 gccgttaggt gtgccactcc cggcgttgcc gccgttgccg ccgttgccga ccaggatggc
2061301 accgccgcca gcgccgccgt caccgccctt ggcaccggtg ccgtttcctc cggcgccgcc
2061361 gtcaccgccg tcgccgatca gcccggcttt gccgccgagc ccaccggcgc ccccggcacc
2061421 gccgaagccg aatccgccgg cgccgccggc accaaacagc aggcccgcag tgccgccgtt
2061481 tccgccggcg ccgcccaccc cggtagcgcc accgccgagt gcgccggcgc cgccggcccc
2061541 gccggcgcct accagcaggc cggcgttgcc gcccgccccg ccggcaccgc cggtagtgga
2061601 cccgacccca cccgcgccgc cggcaccgcc gtcgccccag agcagggcgg acccgccgga
2061661 ccccccggca ccgccgttcc cgaccaatcc gattccgccg gcgccgccgg ccccaccgac
2061721 gccgaacagc ccaccggccc cgccggcacc accgggcccg ccgggggcgg tgcccaggaa
2061781 tgccacaccg tcaccgccaa caccgcccac cccgccggcg ccgaacagga gcccgccatt
2061841 gccgccggcc ccgccggcac cgccggtgac attagtgccg gtgccgccgg ccccgccggc
2061901 accgcccacg ccgaagaaca acccgccgtc tccgccggcc ccgccgtcac cggcgtcagc
2061961 cgcgagtccg ccgacgccgc cggccccgcc ggcgccgaac agcagcccgc cattgccgcc
2062021 ggccccgccg gccccaccaa taccgcccac cccaccaccg gcgcgtccgc cggcgccgcc
2062081 ggccccgccg gcgccgtaga gcagcccgcc ggccccgccg gccccgccga accctgcggt
2062141 gccggacgct acgttccccc cggcgccgcc ggccccgccg ttgccgaaca ggccagcggc
2062201 tccgccgttg cccccgggca tgccggccgc gccggagccg ccggccccgc cgttgccgat
2062261 caagattccg ccgtcgccgc cgtttgcccc ggtccccggg gccccgttgg ctccgttacc
2062321 gatcagtggg cgccccaaca gcgccagggc gggggcgttg atcacgtcga gcacaccctc
2062381 tagcggggcc gcgctggcgg cctcggcggc cgcatacgag cccgccccgg cggtgagcgc
2062441 ccgcacgaac tgctcgtgaa acagcgccgc ctgggcgctc agcgcctgat aggcctgggc
2062501 gtgtccggag aacaatgccg ccatcgccgc cgacacctca tcggcggcgg cggccaacac
2062561 cgtcgtggtc gggaccgcgg cggccgcgtt ggcggtgccg atcgtcgacc cgatacccgc
2062621 caaatcggtc gccaccgccg ctagcgcctc cgggatcgtg accacaaatg acatctggca
2062681 cctcgtcaac accctgtggc cccggcgcgg ggccgctacc gatcgcctgg tcactcccca
2062741 gagatcgacg gattcagcgt atcgcgatca cggaagcggc cacgccgatt tgggaagctc
2062801 gtcccggctt acacttcggc gggcgccgcc tcgactgggg ccagccgcca ttggccgcca
2062861 ccgagtagtt cgagctggtt ttcgtgcagc cgctcgaggg cggggcgatg gctgacgctg
2062921 atcacgatgc agtccggcag ctcgctgcgc agcaattggt agagcgcaaa ctccagcccg
2062981 gtgtccagcg ccgaggtact ttcgtcgagg aagaccgcct tgggtttggt gagcaggatg
2063041 cgagcaaagg caacacgttg ctgctcaccg ggggagagca ccttggccca gtcgcgttcc
2063101 tcgtccagcc ggtcacacag tggggccagc gccaccttgg tcagcgtgtc ccgcagggtg
2063161 gcgtcgggga tggcggccgc agagttgggg tagcacacca cgtcacgcag cgtccccagc
2063221 ggcacatacg gcaactgcga caagaacatc gtctcgttct cgccgcccgg ccggtgcagg
2063281 gtccccgatg cgtagggcca cagttccgcc agactgcgca gcagcgtggt cttgccggcc
2063341 ccagaacgcc cggtgatcac cagcgagcct ccgcggtcca gccgcacatc gagcgggtcg
2063401 atcaaccgat cgccggcagg cgtacgcacc tcgatgtcgt tgagctcgac ggactcgtcg
2063461 tcgctcggtc gggtcaggac cgcgggcagg gcgcggcctt tctcgttggc gtcgaccagc
2063521 ccatgcaatc ggatgattgc tgcgcggaag gacgcaaacg cgtcgtagtt gttgcggaag
2063581 aacgacaacg agtcgtgaat gttgccgaag gaagtcgccg tctgcccgac atcgccgaag
2063641 tcgatctgcc cggcgaataa tcgaggcgcc tggatgaccc acggcaacgg aacaattgtc
2063701 tggctcaccg acagattcca tccattgaat gcgatgctgc gccgaacgta gcgacggtaa
2063761 ttgtcgatca ccggcgtgaa ccgccgctgt agctgggtac cttccacccg ctcgccgcgg
2063821 tagaaaccca ccgcctcggc ggcgtcgcgt agccgaacca gcgcgtaacg gaaagcggca
2063881 ttgagctttt cattgcggaa gctgagccag atcaggggcc gcccgatgat gaacgagatg
2063941 accgtggcca cgaacacata gaccagcacg gtccagaaca ttgcgcgcgg gatggacacg
2064001 ccgaagatat tcagggtgcc cgagagattc cacaggatcg ctgtgaaaga aatcaccgaa
2064061 atgatcgact gcacggcccc gaaaagcagc gtgctggccg tcccgttgga gggagcattc
2064121 ggagtgccgc ctgccccggc ggtgaagata tcgacgtctt gctgaatgcg ctggtcgggg
2064181 ttgtcgatcg tttcgtcgat gaacaggtct cggtagtagg ccctgccgtc gagccagtct
2064241 tgtgtgaggt ggtgggttag ccagaccctc caggcgatga tgaagcgctg cgtcaagtag
2064301 atgtcggcca tgacccgggt cacgtgcagc acggccatca cgctgaaaac cccgatcgac
2064361 atccaaaatc ctcgcacgcc tgagcgtttg accgtgccat cgccagaggc gatgccctcg
2064421 aaggccttct gcaaggccgt gtacatgtcg ttgccttggt agctgaatag cacattcagg
2064481 cgcactgcca gcactaccga aagcaacaac acgccgagca tcagccacac gcgaacgctg
2064541 ttggggccaa cgaagtatgc gcgggtgatc cgccagaact gccggcccca gggcgtcaaa
2064601 tacctgagca gaaccaatat cgcgagcaca cagatggcac tgatcgtcca ggctttgccg
2064661 acccaataca cggaatccgg gaatgctcta gaccaatcga tggacggctt aaacaatttc
2064721 gggcccaagg tcgacgtctc ctcacaaaca gaaatccttc gggcgaaggt acccgaaggt
2064781 tgtcgatagg ctgccgatat gagcaccgac accgccccgg cccagaccat gcatgctggc
2064841 cggcttatcg cgcgccgact taaagccagt ggtatcgaca cggtcttcac gttgtcgggc
2064901 ggccacctgt tttccatcta cgacggctgc cgtgaggagg gcatccgcct gatcgacacc
2064961 cgccacgaac aaaccgccgc ctttgccgcc gaaggctggt cgaaggtgac cagggtgccg
2065021 ggcgtggccg cgctcaccgc ggggccgggg atcaccaacg ggatgagcgc gatggcggcg
2065081 gcccagcaga accagtcacc actggtggtg ctcggcggcc gggcgccggc gctgcgctgg
2065141 ggtatgggct ccctgcagga gatcgatcac gtgccgtttg tggcgccggt ggcccgcttc
2065201 gccgctacag cgcagtcagc cgagaacgcg ggcctgctgg tcgatcaggc gttgcaggcg
2065261 gcggtgagtg cgccgtcggg tgtggcattc gtcgacttcc cgatggatca cgcgttctcc
2065321 atgtcctcag acaatggccg ccccggcgcg ctcaccgagc taccggccgg tcccacccca
2065381 gccggcgacg ccctggaccg ggcggcgggc ctgctttcga cggcccagcg tccggtcatc
2065441 atggcaggta ccaacgtctg gtggggccat gcggaggcgg cattgctgcg tcttgtcgag
2065501 gaacggcaca ttccggtgct gatgaacggg atggcgcgcg gcgtggtgcc cgccgatcac
2065561 cggttggcct tctcacgggc gcggtcaaaa gcgctggggg aggctgatgt cgcgctgatc
2065621 gtcggtgtgc cgatggattt ccgtctgggc ttcggtgggg tattcgggtc gacaacgcag
2065681 ctcatcgtgg cagaccgcgt cgaacccgca cgcgaacatc cgcgaccagt cgcggcgggg
2065741 ctctatgggg atctgaccgc caccctttcg gcgctggccg gatctggcgg caccgaccac
2065801 cagggctgga tcgaggagct cgcgacggcc gagaccatgg cgcgtgatct cgagaaggcc
2065861 gagctggtcg atgaccggat cccattgcat ccgatgcggg tgtacgccga gctggccgcg
2065921 ctgctggagc gggatgctct agtcgttatc gatgcgggcg atttcgggtc gtacgccggc
2065981 cggatgatcg acagctatct gccaggctgt tggctggaca gcggtccgtt tggctgcctg
2066041 gggtcgggtc ccggctacgc cctggctgcc aaactggcgc ggccgcagcg ccaggtcgtg
2066101 ctcttgcagg gcgacggcgc gttcgggttc agcggcatgg aatgggacac gctggttcgg
2066161 cacaacgtgg cggtcgtgtc agtgatcggc aacaacggca tctggggttt ggagaagcac
2066221 ccgatggaag cgttgtacgg ctattcggtg gtggccgaac tgcgcccggg aacccgctac
2066281 gacgaggtgg tgcgcgcact gggcggccac ggcgagctgg tgtcggtgcc cgctgaactt
2066341 cggccggcgc tggaacgggc ctttgccagt ggcctgcccg ctgtggtcaa cgtgctcacc
2066401 gacccaagcg tggcttatcc acgccgatcc aacctggctt gacgtccagc cgggccgtga
2066461 acgtgcacgg ttgtccacga attgcggcct gtcggtgtac agacacgcac cctcgcggcc
2066521 ggccggcatt cgcgtaccgt tggtttgtgc ccaagaccac ccgcgctcaa cccggccggc
2066581 tgagcagccg attctggcga ttgctcggcg ccagcaccga aaagaaccgg agccgctccc
2066641 tggcggatgt aaccgcttcg gcagaatacg acaaggaagc tgccgatctg tccgacgaga
2066701 agctgcgtaa ggcggcaggc ctgctcaacc tcgacgacct cgcggagtcc gccgatatcc
2066761 cgcagtttct cgcgattgcc cgggaagccg ccgagcggag gaccgggctg cgaccatttg
2066821 atgtgcagtt gcttggcgcg ttgcgcatgc tcgccggaga cgtgatcgag atggccaccg
2066881 gtgagggcaa aacccttgcc ggggcgatcg cggccgccgg ttatgcgctg gccggccggc
2066941 acgtgcacgt cgtgacgatt aacgattacc tggcccgccg cgatgcggag tggatgggcc
2067001 cgctgctgga cgcgatgggc ctgacggtcg gctggatcac cgcggactcg acccctgacg
2067061 agcgccggac cgcatatgac cgtgatgtca cctatgcctc ggtcaacgag attggcttcg
2067121 atgtactgcg cgatcagttg gtgactgatg tcaatgacct ggtatcgccc aatccagacg
2067181 tggctctcat cgacgaagcc gactccgtgc tggtcgacga ggcgctggtg cccctggtgc
2067241 tggccggaac cacacatcgt gagacgccgc ggctggagat catccggctg gtcgctgagc
2067301 ttgttggcga caaggacgcc gacgagtact ttgccaccga ttccgataac cgcaatgtcc
2067361 acttgaccga gcacggggca cgcaaagtcg agaaagcgct cggtggcatc gacctgtact
2067421 ccgaggagca cgtcggcacc acactgactg aggtcaatgt cgcgctgcac gcgcatgtgc
2067481 tcctgcaacg cgacgtgcac tacatcgtcc gcgacgacgc ggtgcacctg atcaacgcgt
2067541 cgcgtggccg tatcgcgcaa ctgcagcgct ggccggacgg gttgcaagct gcggtcgagg
2067601 ccaaggaagg tatcgagacc acggaaactg gggaagtgct cgacaccatc acggtgcagg
2067661 ccctgatcaa ccggtatgcg actgtgtgcg gaatgacggg aaccgcgctg gccgccggtg
2067721 agcagctacg gcagttctac cagctcggtg tctcaccgat accaccgaac aagccaaaca
2067781 tccgcgagga cgaggccgac cgggtctaca tcaccactgc agccaagaac gacgggatcg
2067841 tcgagcacat caccgaggtg caccagaggg ggcagcctgt gctggtcggt acccgcgacg
2067901 tggccgaatc cgaggaactg cacgaacgcc tggtgcgccg cggtgtgccc gccgtggtgc
2067961 tcaacgcgaa gaacgacgcc gaggaggccc gggtcatcgc cgaggccggc aaatacggcg
2068021 cggtcacggt gtcaactcaa atggccgggc gcggcaccga catcaggctc ggcgggtccg
2068081 acgaagctga ccacgacagg gtcgcggaat tgggcggcct gcacgtggtc ggcactggcc
2068141 gtcaccacac cgagcggcta gacaaccagc tgcgcggtcg ggccgggcgc cagggagatc
2068201 ccgggtcgtc ggtgtttttc tcaagctggg aagacgatgt cgttgcggcc aacctcgacc
2068261 acaacaagct gccgatggca accgacgaaa atggccggat tgtcagcccg aggacgggta
2068321 gtctgctcga ccatgcccag cgcgttgccg agggccggtt attggatgtg cacgccaaca
2068381 cgtggcgcta caaccagctg atcgcccagc agcgcgccat catcgtcgaa cggcgtaaca
2068441 cgttgttgcg caccgtaacc gcgcgtgagg aactcgccga actggcgcct aagcggtacg
2068501 aggagctgtc cgacaaagta tccgaggaac gcctcgagac gatttgtcgg cagatcatgc
2068561 tgtatcacct cgaccgtggc tgggccgatc acctggcgta tctggccgac atccgggaga
2068621 gcatccatct acgcgcgctg ggccggcaga acccactcga cgagtttcac cggatggctg
2068681 tggacgcgtt cgcgtcgctg gccgccgacg ccatcgaggc ggctcaacag acgttcgaaa
2068741 ccgcgaacgt ccttgaccac gagccggggc tggacctgtc caaactggcc cggccgacgt
2068801 cgacatggac ctacatggtc aatgacaacc cactgtccga tgacacgctt tctgccctca
2068861 gtctgcccgg ggtgttccgc tgagctgccc agcgtaagcg ccgagcgtaa cgccactgcg
2068921 aaatttcggg cagaaaatcg cagtggcgtt acgctcgcgg ctaggggtgc ccccacagcc
2068981 cgccgtttcg gcgcgcatcg tcgccaggct agatccgatt gcccggctcc tcagcccgcc
2069041 gtttcggcgc gcatcgtcgc caggctaagg tcacggctca tggagccggt gctcacgcag
2069101 aatcgggtgc tgactgtccc caacatgttg agcgttattc gcctcgcgct catcccagca
2069161 ttcgtctacg tcgtgctcag cgcgcacgcc aatggctggg gggtagcgat cctggtgttc
2069221 agtggcgttt cggactgggc tgatggcaag attgcacggc tactaaacca gtcatcgcgg
2069281 ctgggcgcgc tgctggaccc ggccgttgat cgcctctaca tggtcactgt tcctatcgtg
2069341 tttggcctga gcggcatcgt gccgtggtgg tttgtcctta cgttgctgac ccgcgatgcg
2069401 ctgctggctg ggacgctgcc gctgctatgg agccgtggac tgtcagcgct accggtgacc
2069461 tacgtcggta aggcagcgac tttcggcttc atggttggct ttccgaccat tctgttgggg
2069521 caatgcgatc cattgtggag ccatgtgctg ctggcctgtg gttgggcatt cttgatctgg
2069581 ggtatgtatg cctacttgtg ggccttcgtg ctgtatgcag tgcagatgac gatggtggtg
2069641 cggcagatgc ctaagctcaa gggcagggct catcggccgg cggcccagaa cgctggtgaa
2069701 cgtggctgag tctgaccggc tgctcggcgg ctacgacccc aacgccggct acagcgccca
2069761 cgcaggggcg cagccacaac gcatcccggt tccgtcgttg ctgcgcgcgc tgctatcaga
2069821 gcatctggat gctggatacg cggcggttgc cgccgagcgc gagcgtgctg cggcaccacg
2069881 gtgttggcaa gcccgcgccg tcagctggat gtggcaggca ttggccgcga ccctagtcgc
2069941 cgccgtgttc gctgccgcgg tagcgcaggc gcgctcggtg gcacccggcg tgcgcgccgc
2070001 ccaacagttg ctcgttgcga gtgtgcgatc aacccaggcc gccgcgacca cgttggctca
2070061 acggcgcagc acactctcgg cgaaagtcga cgacgtgcgg cggatcgtac tcgcagacga
2070121 cgccgaggga cagcggctgc tggcccgtct cgacgtgctt agcctggccg cggccagcgc
2070181 accggttgtc gggcctggtc tgacggtgac cgtgaccgat cccggtgcga gccctaatct
2070241 ttccgacgtg tccaagcagc gggtcagcgg tagccagcaa atcatcctcg accgcgattt
2070301 gcagctcgtc gtcaactcac tgtgggaaag tggcgccgag gccatctcga tcgatggcgt
2070361 ccggatcggg ccgaacgtca cgatccggca agccggcgga gcaatcttgg tcgacaataa
2070421 tcccacgagt agtccctaca ccatcttggc ggtcgggccg ccacatgcca tgcaggacgt
2070481 cttcgatcgc agcgccgggc tgtaccgcct gcggctgctg gagacctcct acggtgtcgg
2070541 cgtcagtgtg aacgtcggcg acggtctggc attgcctgcc ggtgcgaccc gggatgtcaa
2070601 gttcgccaaa cagattgggc cctagtgaga gaagtcctgg tgaataggaa accatgggga
2070661 gcgatacggc ctggagtccg gcgcgcatga tcgggatcgc ggcgctcgcc gttggaatcg
2070721 tgctgggttt ggttttccat cccggcgtgc cagaggtcat ccagccgtat ctgccgatcg
2070781 cggtggtcgc cgcgctcgac gcggtgttcg gtggcttgcg cgcctatctc gagcggatct
2070841 ttgacccgaa ggtcttcgtg gtttcgttcg tgttcaacgt tttggtggct gccctaatcg
2070901 tctatgtcgg tgaccaactg ggcgtcggca cacagttgtc caccgcgatc atcgtcgtgc
2070961 tgggcatccg catcttcggc aacaccgcgg ccttgcggcg gcggttgttc ggagcgtgac
2071021 ggagatgaga tcaccgtgag tgagaatcgc ccagaacccg tggcagccga gacttccgcc
2071081 gccacaactg cgcgtcactc ccaagccgac gcgggcgctc acgacgccgt gcgacgtggt
2071141 cgtcacgaac taccagccga ccatccgcgc tccaaggtcg gaccgctgcg gcggacaaga
2071201 ttgaccgaaa tactgcgggg tggtcgctcg cgtctggtgt tcgggacgct tgcgatcttg
2071261 ttgtgcttgg ttctgggggt tgccatagtc actcaggtcc gtcagaccga ctccggtgat
2071321 tcattggaaa cagcccgtcc tgcagaccta ttggtgttgt tggattcgtt gcggcaacgc
2071381 gaggccacgt tgaacgccga agtgatcgac cttcagaaca cgctgaacgc gttgcaggca
2071441 tccggcaaca ccgatcaggc agcgttagaa agcgcccagg ctagattggc cgcgttgtcc
2071501 atcctggtcg gcgccgtggg tgccaccggg ccgggcgtca tgataacgat cgacgatccg
2071561 ggacccggag tagcgcctga ggtgatgatc gacgtgatca acgaactgcg tgccgctgga
2071621 gccgaggcga tccagatcaa cgatgcacac cggtcggtgc gggtcggggt tgacacctgg
2071681 gttgtcggtg tgcccggctc actgacagtc gacaccaagg tcctgtcccc gccgtattcg
2071741 attctggcga ttggtgatcc tccaacgctg gccgcggcga tgaacattcc tggtggtgca
2071801 caggacggtg tcaaacgcgt cggcgggcgg atggttgtgc agcaggccga ccgtgtggac
2071861 gtgaccgcct tgcggcaacc aaaacagcac caatacgctc agcccgtcaa gtgaactagc
2071921 ccaactccga gccgaccaga ataggattac cgtgagcgat atcccgtccg atctgcacta
2071981 caccgccgaa cacgagtgga ttcgccgcag tggcgacgac accgtccggg tggggatcac
2072041 cgactatgca cagtcggcgc ttggcgacgt cgttttcgtt cagctacccg ttatcggcac
2072101 cgcggtcacc gccggcgaga ccttcggcga agtggaatcg acgaaatctg tgtcggatct
2072161 ctatgcgccc atttcgggta aggtgtctga ggtcaacagc gatctggacg gcactccgca
2072221 attggtgaat tccgacccct acggagccgg ctggctgctg gacatccagg tcgacagctc
2072281 ggatgtcgct gccctggagt cagctttgac gacactgctc gacgctgagg cctaccgcgg
2072341 cacactgacc gagtgacgat tgctaaggtc cctgccagcg tcacgtggga ggtcgcgggt
2072401 ctgcacggat ccgggccggg cagggcaatc gagcctggga tccgctgggg tgcgcacatc
2072461 gcggacccgt gcgcggtacg gtcgagacag cggcacgaga aagtagtaag ggcgataata
2072521 ggcggtaaag agtagcggga agccggccga acgactcggt cagacaacgc cacagcggcc
2072581 agtgaggagc agcgggtgac ggacatgaac ccggatattg agaaggacca gacctccgat
2072641 gaagtcacgg tagagacgac ctccgtcttc cgcgcagact tcctcagcga gctggacgct
2072701 cctgcgcaag cgggtacgga gagcgcggtc tccggggtgg aagggctccc gccgggctcg
2072761 gcgttgctgg tagtcaaacg aggccccaac gccgggtccc ggttcctact cgaccaagcc
2072821 atcacgtcgg ctggtcggca tcccgacagc gacatatttc tcgacgacgt gaccgtgagc
2072881 cgtcgccatg ctgaattccg gttggaaaac aacgaattca atgtcgtcga tgtcgggagt
2072941 ctcaacggca cctacgtcaa ccgcgagccc gtggattcgg cggtgctggc gaacggcgac
2073001 gaggtccaga tcggcaagtt ccggttggtg ttcttgaccg gacccaagca aggcgaggat
2073061 gacgggagta ccgggggccc gtgagcgcac ccgatagccc cgcgctggcc gggatgtcga
2073121 tcggggcggt cctcgacctg ctacgaccgg attttcctga tgtcaccatc tccaagattc
2073181 gattcttgga ggctgagggt ctggtgacgc cccggcgggc ctcatcgggg tatcggcggt
2073241 tcaccgcata cgactgcgca cggctgcgat tcattctcac tgcccagagg gaccattacc
2073301 tgccgctgaa ggtgatcagg gcccagctgg acgcccagcc cgacggtgag ttgccaccat
2073361 tcggatctcc ttacgttcta ccgcgattgg tgcccgtagc cggcgacagt gctggcggcg
2073421 tcgggtcgga caccgcgtcc gtgtcgctca cgggtatccg gctcagtcgg gaagacctcc
2073481 tggaacgatc ggaagtggcc gacgagctac tgacggccct gctcaaagcc ggtgtgatca
2073541 ccaccgggcc gggcggcttc ttcgacgaac acgccgtcgt gatcctgcaa tgcgcacgag
2073601 cgctggccga atacggcgtc gagccgcggc atctacgcgc cttccgctcc gcggccgacc
2073661 ggcagtccga cctgattgcc cagattgccg gcccgctcgt caaggccggc aaggccggtg
2073721 cccgcgaccg ggccgacgac ttggcccgtg aggtggccgc gcttgctata actttgcaca
2073781 cgtcgctgat caagtctgcg gttcgcgacg ttcttcaccg ctgaggacta gacttcgttc
2073841 gacagcttgg tgttcgacgt cacggtagag acgtggcgcc caccgcgtcg tcgcaccgag
2073901 cgtgagtcgg acaccggttg catgtgcgga gggcagacgc agatgggtga agttcgtgtt
2073961 gtcggcattc gcgtcgagca gccgcagaac cagccggtgc tgttattgcg cgaggccaac
2074021 ggtgatcgat acctgccgat ctggatcggc cagtcggagg ctgccgctat cgcgctggag
2074081 cagcaaggcg tcgagccgcc acgtccgctg acccatgatc tgatcaggga tctcattgct
2074141 gcgctggggc attcgctcaa agaggtgcgc attgtagacc tgcaggaagg aactttctac
2074201 gctgatctga tcttcgaccg caatatcaag gtgtccgccc gtccctcgga ctcggtggca
2074261 atcgcattgc gagtgggtgt tccgatctac gtcgaggagg ccgtactagc ccaggccggt
2074321 ctgctgattc ccgacgaaag tgacgaggag gccaccaccg ctgttcgcga ggacgaggtg
2074381 gagaaattca aagagtttct cgacagtgtg tcacctgacg atttcaaggc cacctagcgc
2074441 ggcgacgatg cgcgccggga cggcgggctg aggaggcgcg cgataaggcc gagcgcggcg
2074501 acgatgcgcg ccgggacggc gggctgagga ggcgcgcgat aaggccgagc gcggcgacga
2074561 tgcgcgccgg gacggcgggc tgaggaggcg cgcgataagg ccgagcgcgg cgacgatgcg
2074621 cgccgcgacg gcgagcatcc attatttgcc ggccagcaac gtcacggctg cgtctcatct
2074681 ctggctgcaa ttgtcgacac gcctagcggt tagtgcctaa tgcgcccggc gaccgcgata
2074741 ctttgatcac gacctgatag ttaaccggga gcatcgcgcc catcgaacag cgtatgctct
2074801 ctaacactcg ggccctcagt aatggctgtc gggggagcca gtgacgcagc tagtgacaag
2074861 agcgcgatcg gcgagaggaa gcaccttggg cgagcagcca cgtcaagacc agctcgactt
2074921 tgctgaccac acgggcactg ctggtgatgg taacgacggc gccgctgcgg ccagcggacc
2074981 cgtgcagccc ggcctgttcc ccgacgattc cgttcctgac gagttggtag gttatcgcgg
2075041 accgagcgcc tgccagatcg ctgggatcac ctaccgccag ctcgactatt gggcgcgcac
2075101 atcgttggtt gtgccgtcga tccgtagtgc ggcaggatcc ggcagccagc ggctgtactc
2075161 gttcaaggac atcttggttc tcaagatcgt caaacggttg ctcgacaccg gtatctcgct
2075221 gcacaacatc cgggttgcag ttgaccatct gcgccagcgt ggcgtccagg atctggccaa
2075281 catcaccttg ttctccgatg ggaccaccgt gtacgagtgc acgtcggccg aggaggtcgt
2075341 cgacctcctg cagggcggcc agggtgtgtt cggcatcgcc gtctcgggcg cgatgcggga
2075401 gctgacgggt gttatcgccg acttccacgg tgagcgcgcc gacggcgggg agtcgattgc
2075461 tgcccccgaa gatgaactgg cctcccgacg caagcatcgc gaccgcaaga tcggctagcc
2075521 gagagttccc ccgcgaacag acacagaatc gcacgcggca ggctcctcgg atgcgattgt
2075581 gtgtctgctc ggcagtagac tggacaacgc atcgctctag tgcgggagag ttctgtggct
2075641 gccagctacg gacgccgaag gagcaatacc tctccgtcaa cctctcaggc acccggaccg
2075701 cgcgagacta cgatgcctct ggaaagcggt ggcgacccct ggcggtcctc acccgccgat
2075761 ggggaaaggc gattcacctg acggtggaca gagtcgccga atctctcagg cgcctggcgt
2075821 gcaggtgaag acagagggag agggccgcta gtcctctgct ttgtcaggag ttcaccgtgt
2075881 ccgaccattc gacgttcgca gaccggcaca tcggtctgga cagccaggcc gtcgcgacca
2075941 tgctcgccgt gatcggggtg gattcgctcg atgacctggc agtcaaggcg gtcccggcgg
2076001 gcatcctaga cacactcacc gacaccggag ccgcaccggg tttggacagt ctgccaccgg
2076061 ctgccagcga agccgaggcg ctggccgagc tgcgagcgct ggccgacgct aacaccgtcg
2076121 ccgtgtcgat gatcgggcaa ggctactacg acacacacac ccccccggtg ctgttgcgca
2076181 acatcatcga gaacccggcc tggtataccg cctacacgcc gtaccagccc gagattagtc
2076241 agggtcggct ggaagccttg ctgaacttcc agaccctggt caccgatctg accggcctcg
2076301 agatcgcgaa cgcgtcgatg ctcgacgagg gcaccgcggc ggccgaggcc atgactttga
2076361 tgcaccgcgc ggcccgcggg ccggtgaaga gggtggtcgt ggacgccgac gtgttcaccc
2076421 agaccgcggc ggtgctggcc acccgcgcca agccgctggg tatcgagatc gtcacggccg
2076481 acctgcgcgc cggtctgccc gacggcgaat ttttcggcgt catcgcccag ctgcccgggg
2076541 ccagcggccg gatcaccgac tggtctgccc tggtgcaaca ggcccacgac cgtggcgcac
2076601 tggtggccgt cggcgccgac ttgttggcgc tgacgctgat cgcgccgccc ggagagatcg
2076661 gcgctgacgt cgcctttggc accacacaac ggttcggagt gccgatgggg tttggcggcc
2076721 cgcatgccgg gtaccttgcg gtgcacgcca agcatgcgcg tcagctgccc ggccggctgg
2076781 tcggtgtgtc cgtcgacagt gacggcacgc cggcctatcg gttggcgctg cagactcgcg
2076841 agcaacacat ccgccgcgac aaggccacca gcaacatctg caccgcacaa gtgctgttgg
2076901 cggtgcttgc cgcgatgtac gcgagctacc acggcgcggg cgggctgacc gccatcgcac
2076961 gccgggtgca tgcccacgcc gaggctatcg ccggtgcact gggcgatgcg ttggtgcacg
2077021 acaagtactt cgacacggtg ttggcccggg tgcccggtcg tgccgacgag gtgctggcca
2077081 gggccaaggc caacggcatc aacctgtggc gtgtcgacgc cgaccatgtg tcggtagcct
2077141 gcgacgaagc caccactgac acccacgtgg cggtcgttct ggacgcgttc ggtgtagcgg
2077201 ccgccgcacc cgcccatacg gacatcgcaa cgcgcacatc ggagttcctg acgcatccag
2077261 cgttcacgca ataccgcacc gagacgtcga tgatgcggta cttgcgtgcg ctggcggata
2077321 aggatattgc cctcgaccgc agcatgattc cgctcggctc gtgcacgatg aaactcaacg
2077381 ccgccgccga gatggagtcg attacctggc ctgaattcgg gcgtcagcat ccatttgccc
2077441 cggcatctga taccgctggg ctgcgtcaac ttgttgccga cctacagagt tggctggtgc
2077501 tgatcaccgg ttatgacgcg gtgtcgctgc aacctaacgc gggctcgcaa ggcgagtatg
2077561 cgggcctatt ggcgatccac gagtaccacg ccagccgggg tgaaccgcat cgcgacatct
2077621 gcctgatccc gtccagcgcg cacggcacca atgccgcgtc agccgccttg gccggcatgc
2077681 gcgtggtggt ggtggactgc cacgacaacg gcgacgtcga cctcgatgac ctgcgcgcta
2077741 aggtcgggga gcatgccgag cggttgtcgg cgctaatgat cacctacccg tccactcacg
2077801 gcgtgtacga acacgacatc gccgagatct gcgctgccgt gcacgacgcg ggcggccagg
2077861 tatacgtcga cggagccaac ctcaacgccc tggtcggcct ggcccggccg ggcaagttcg
2077921 gcggtgacgt cagtcacctc aacctacaca agacattctg cattccgcac ggcggcggtg
2077981 gcccaggcgt cggcccggtg gcggtgcggg cgcacctggc accgtttctg ccaggtcacc
2078041 ccttcgcccc cgagctgccc aagggctatc cggtgtcgtc ggcaccatat gggtcggctt
2078101 cgattcttcc gatcacctgg gcatacatcc ggatgatggg ggctgaggga ctgcgggcgg
2078161 catcgctgac agcgatcacg tcggctaact acattgcgcg ccgccttgac gagtattacc
2078221 cggtgctgta caccggcgag aacggcatgg tcgcccacga gtgcatcctg gacttgcgcg
2078281 gtatcactaa gttgaccggt atcaccgtcg acgatgtcgc aaaacggctg gcagactatg
2078341 gttttcacgc accaacgatg agttttccgg tggccggtac gctcatggtg gagcccaccg
2078401 agagcgagag cctggccgaa gtggacgcct tctgcgaggc catgatcggc atccgcgccg
2078461 agatcgacaa agtcggggcc ggggagtggc ctgtcgacga caatccgctg cgcggcgcac
2078521 cgcacaccgc gcagtgcctg ctggcgtctg attgggacca cccgtatacg cgggaacagg
2078581 ccgcctaccc gctcggcacc gcattccgac ccaaggtttg gcccgcggta cgtcgcatcg
2078641 acggcgccta cggggatcgc aacctggtct gctcatgccc gccggtagag gcttttgcct
2078701 aaacgctcgt cgaccggccc ccggtcgagc tcgaggcccg ggtgctactg ggtgggtagc
2078761 tgacgtgtcg gctgctatgg gtcgttgtcg gggttgcgga gtttttcggg gtggcggcag
2078821 gtgttggtgc ggggttgacc gtggtcggag gtggggtggg gagctattcg gtgtcgccac
2078881 ccgcgctcca acaatgccag ctgttgcggg gtgctcagcg acaaaggttc agccgaagcg
2078941 ctcaatgatc gcggcggcga tccggtcggg ggcgtcctcc tggatgaagt gtttggcgtt
2079001 gggcagctcc accaggacgt ggtcgggaaa tgtcgcactc agtctgggga taatcgtttt
2079061 cggcctgaat gcgacatcct tcatccccca aatcaacagg gtgggcttgg tgcccagcgt
2079121 ggctggcacc tcccgggcga gccgtgccag caggggacgg gcggccagga tctgtttggg
2079181 catctcggct acgcctcggc gtgccgcggc gttgggctgc accgcccggt agtgcgccat
2079241 caccgcgcta ctcggccggt gctcggttcc cgcgggtatc aagcgctcga caaagaagtt
2079301 gcgccgtaag atcgcgtact gcactggcgg gctggacatc accctgctga aggccttcat
2079361 cgccagcgtg tccgccggcc agaaccacgt gttgcccaac acgacgccgc ggacccggtc
2079421 ggcacgctcg acagcgaccg ccatgctgat cgggccaccc cagtcctgac ccatgctcag
2079481 gtagcggtcc aggcccaggt gatcgacgaa ttcgccgatc acccgcgcgt gctcgtcgat
2079541 ctggtacccg aatcccgagg gacgctccga taacccgaaa cccagataat ccggagccac
2079601 acaacggaaa cggtcccgca gtgcgacgat gatgtcccga tacaggaaac tccacgtcgg
2079661 gttgccgtga cacaacagga tcggcggacc cgtgccctcg tcgacgtagt ggatgcgtcc
2079721 acgcgagctg tcgaaccagc gcgactcgaa cgggtacagc tgcggatccg gcgtgaaatc
2079781 gatgctcatt accctcctcc gatcgcgctc atgatggtat gcccgaaggg tgacatcacc
2079841 gagtgtccgg gagtggcgtg acggtggccg ctggctgccg acggctgtcg gaaaggtgtt
2079901 cgtccggtcg gggccgggcg acacgccaac aatgctcctg ctgcatggct atccgtccag
2079961 ttcgttcgac ttccgggcgg tgattccaca cctgaccggc caggcttggg taacgatgga
2080021 ttttctgggc tttggcttgt ccgacaagcc gcgcccgcac cggtacagcc tgctggagca
2080081 ggcccacctg gtggaaacgg tggtcgccca caccgtgacc ggcgcggtcg tcgtgctggc
2080141 ccacgacatg ggcacgtcgg tgaccaccga gctgctagcc cgtgatttgg acggccggtt
2080201 gccgttcgat ctccgacgtg cggtgctgag caacggcagt gtgatcttgg agcgggccag
2080261 cctgcgtccg atccagaaag tactgcgcag cccgcttggt ccggtcgctg cccggctggt
2080321 cagccgcggt ggcttcacac gagggtttgg ccggatcttc tccccagcgc acccgctgtc
2080381 ggcgcaggag gcccaagccc agtgggagtt gctgtgctac aacgacggca accggatccc
2080441 gcacctgctg atcagctacc tcgacgagcg gatacggcac gcgcagcgct ggcatggcgc
2080501 ggtccgcgat tggcccaaac cgcttgggtt cgtgtgggga ctcgacgatc cggtggcaac
2080561 aaccaacgtg ctcaatggac tacgggaatt gcgccccagc gccgccgtcg tggaactgcc
2080621 agggttgggc cactacccgc aggtcgaggc tcccaaagca tatgccgagg ccgcgctatc
2080681 gctgctcgtc gactagccgg ctacggctgt atcacgggca gatcgatgcg agaggcatgc
2080741 atccggctac ggtagacgcg cacggtcggt gcgcaaccgg gaaggatggc gaagtggctt
2080801 gcgtccgcgc cggcgatggc gatgcggatg cggtgccccg gttggaacag atacgacgtc
2080861 ggcagcaggt cgaatgtcag ccgggcaatc tcgcccggga ctaggggcca cgcgtccccg
2080921 ctcgcgaacg ttcggtaggg gaccacctgg cggtacggcg gcggcccgtc gctgagccgg
2080981 cggtggatgg cgcgtagctg gccctcggtg atgtaggcga cacggccgcg cggatcgacg
2081041 tcttccagat agacgaagaa ggtgccgtcg ctcgacgtcg acgtgataaa cagcgtgacc
2081101 accacatgac cggtcacctc caggggatgg tcgagcggtg cggaggtata ggtcagcagc
2081161 ttggcatcct gggccttgcg gtccgggtag caaacgtgtc caccgatgcc cacttgcgag
2081221 cgccagcgtg agcgctcgcc cgttccggcc gtctgatcca ccacgtattc gtctgcaccg
2081281 ctgtcgcaat cgggtgcgtc cgggcgcagc tgtcggtctg cggacaggta gtagctctgc
2081341 gtggtggcgg gcggcggcca ggtgtcggcc gacttccagc ggttctcgac catggtgaag
2081401 tagtgcaccg gcggctcgga gccgatgccc gtatcggccc ccttgacgtg atggtcgatg
2081461 aacctcaaca gctcgccgtc gtgatcgaag tcgggtctgc tgagcccgcg cagtgggtcg
2081521 acgcgccagc cgccggtgtg gttccatgga ccgaggatca agtggctgcc cggggtggag
2081581 acggtcagaa aacgtttgat tgcggcatgc gcatacccgc cgtcgaacca gccgctgtag
2081641 ctgtagatgg ccgctcccga cgcctgcacg tcacgccaat aattgtgcgg gctgatcagg
2081701 ttgatgctgc ccgactcgat cggtgtaccg atcggctcga gccgggcgtc aggttggcca
2081761 cgatagggat ccgaggcgga tacgtcgtcc cggaacgtca atgaccccgc gatctggtga
2081821 acgtcgtagt tgccgcgatg cgcggcgatg gccccgtccc gcagcgagcg atcacggtcc
2081881 tcctgcaccg gctgcatgcc ggtcaccggg agcttcgccc accacccgac cacttcgtgc
2081941 agggcgttgc ggtcgagcgc ctcgttgtag cgtccccagg tgtcggtgaa ccaggcggcg
2082001 tggatgccgc cggggaacgc gatgtcggtg tagacgtcga acagcgagaa gcacggggcg
2082061 atcacccgca ccgcgggatg ctggttgacc agcagtaact cggccgacgt gccgtcgtac
2082121 gaatttccca gcgcagcgac cgttccgttg caccaaggct ggcgcacgat ccagtcgacg
2082181 atctcggcgc cgtcccggat ctcgtcggag gaccattcgc acacgcgggc gccgaacgac
2082241 gcgcccgatc cgcgcacatc cacatcgacc caggcgtagc cgctggcgac gaaacgtctc
2082301 cgacgacgct tatctgcggc gatgtgctgg aggggcttgc ccccgagcaa catccgcaac
2082361 ggccagcgca actgcagcga ccggtagtag cgggtctgat gcaggatcgc gggcagcctt
2082421 gcggcactcg tcaggcccgc gggcaggtag aggtcgatgg cgatgcgcac cccgtcgcgc
2082481 atcgtcacat agcacgagga gtagcgcatc ccacgatatc tcgggtaggc ggatcgttgg
2082541 tccggcgcgg agtaccaggc cgcatccgag ccgccgcgtc tggtcatcgg gtagccaggc
2082601 gatcagctca agaagatgtt gaccgcggtt gccaggtcgg gggatgccga tgtctccagg
2082661 ttttggtagc tgccgccgct gagctgtgcg acggcttccc aggttgcccg atcgggatca
2082721 gcaccgaagt cgatgatgtt gaccgcgatc ggcttggccg ggtctgcgct cttgcggatg
2082781 aaatcctgca ggcccggccc gtcgagggtt tggtccgtat gcggccccgc ggtaataacc
2082841 agcacagaat tagcctggcc aacacggtaa ttggctagca tctcctgata gatcaagcgc
2082901 agagtggtga acgacaccgc gccaccgccc gaggagtatt gcttgcccaa cgcggccgtc
2082961 aaggccgcgg ggcggggctg gccgttgacc gggtcggcca atggcccggc cggcacctct
2083021 gttcggccct cgcggccgtc gaatgtccac agtccgacga ccgaactggg cggcatcgcc
2083081 ttgatccggt tctcaagcgc cgcaacgaca ttgctaagcc ggctattgcc gccttcatca
2083141 ttgggcatcg attggtcgag catgatggtc gcggccactc cggccgacgc ggtgaccatg
2083201 gtgtccgcca gggtcgcgcg catggagtcg tcacccaccg acaaagtcga aggcagcgct
2083261 gggaaactgg tgacggggct gctcggcggt ttgacgtcgc tgactcggaa accagctctg
2083321 gccagtttgg ccagttgctc gggcttgtgc aaatacctgg caaacgcgct ggccgccgac
2083381 gtttgctcct gcgatagcca tgcaccactg agcagcaccg tcggatagtc agcgaccgca
2083441 gccggccccg gcggcagcca ggaacccaag gtgttctcgg catctgaaag tgactggccg
2083501 cgctggaaca actgttgttc ggtggtgacc accgcgtgca cgggtgccgt ggcgacatcg
2083561 ccgggcttga gcagcgtgtc catcgccgcg gtcaaggagt cgtcggcgag cttaggtcgt
2083621 gcgcccatca gggtgcgcac cgcgccgata cccgctgttg ctggcgcgcc agcaggtgct
2083681 gacgcggcag ccaccgcctc gccggccaaa tacgcggcat cgccgttgcc actgctcggc
2083741 attgccagcc gcagtgatcc ccaggcaggc aagtccaagc cggacaacga gttcggattg
2083801 gtttgcaggc cgggcaacgc cgcccagttc tggttggcga gggcctgctg caattcgggc
2083861 cgcacggcga gcaacaccgg cgatatcacc agtgagcggc tatcgctaat ggcttggctg
2083921 cccgcggccc cggtaagccg cgccgccgag atggagctac tcggaatcca caatcccggc
2083981 tggccgccca gttcggtcgg ccatttgccg atgaaaccat tgatgacggc atcggagccg
2084041 gccgaggtga cagccactgc cacacaacgg tcgccgaccg ggcccgccga cgcgttgtag
2084101 ctgtcggctg actcctttac ctgatcggcg attgatgggt cggctataac agcgacggtg
2084161 tccttgccgc ccacgcagcg ggcggcagcc gtatgcgagc ggttggacaa cgcgtcaccg
2084221 aagaagcgcc acaagatcac cccggccacc attaccacca ctgcgacaag ggccacgatc
2084281 acgccgatac tgactccccg ccgcccgtcc gcgctacggt gcccggcctg ccagtcgccg
2084341 ggcccccgat gtccgaagcg aaacagcggc ggcggggcgg ccgctatggg ctcggcaccc
2084401 gttggctccc agtcggggcg gggtggaatg tcagggtagt cttctgagcc gctagccgag
2084461 tagccgccga cggcggagta gtggccctcg ctggataacg ggccgtcatc gggctgatct
2084521 acaccgggat agtcgtagct acccgatatg tcctcccagt gctgttgttc cgccgcatgc
2084581 ccgtcggaca ggtcgtcaac ggaatcctcg gggtcgggct tgctgtgcct acccataccg
2084641 gcgtctgcgt cctctccgtc gaaggccggc gcctgtcaag cacgagctac gcaccggctc
2084701 tgcccgatgg ggccggctct ctcccgcaag cgggcggtgc ccccacagcg gcccgctagc
2084761 gggccgcatc gtcaccggcc ctgtccgatg gggccggctt ctcagcggcc cgggccttaa
2084821 actcccgacg acgtcggtgc aggatcggct cggtgtagcc gttgggctgc tgggccccgg
2084881 acaagatcag ctcctgcgcg gccaggaagg cgatactgtc gtcgaagttg ggtgccatcg
2084941 gtcggtatgc cacgtcgccc gcgttttgtc gatcgaccaa cggcgccatc cgctccaagc
2085001 tggcccgcac atccgcgctg gtgatcacac cgtggcgcag ccagttggcc aacaattggc
2085061 tggagattcg cagcgtggcc cggtcctcca tgagcgcgac gtcgtggatg tcgggcacct
2085121 tcgagcagcc gacaccttga tcaacccagc gaaccacgta gccgaggatg gattgacagt
2085181 tgttgtcgac ctcttcgcgg atctcgtcgg gagcccaggc caattccttg gccagcggaa
2085241 tggtcagcaa ttgttcgatg gtggcgcgac gcttccccgc cagtccttgt tgcaccgcgg
2085301 cgacgtcgac ctggtggtag tgcagcgcat gcagggtggc cgcagtggga gagggaaccc
2085361 aggcggtgct ggccccggcg cgcggctggg cgatttttgt ctcgaccatg tcggccatca
2085421 gctcggtcat tgtccacatg cccttgccga cctgggctcg gccgctgaac ccggcggcca
2085481 ggccggcatc gacgttgtgg tcctcgtagg ccaagatcca cggctggctc ttcatggtgc
2085541 ccttgcgcac catcgggccg gcctccatcg aggtgtggat ttcatcgccg gtgcggtcca
2085601 ggaacccggt gttgatgaac accacgcggt ccgcggcagc tttgatgcac gccttgaggt
2085661 tgaccgtggt ccggcgttcc tcgtccatga tgccgatctt catggtgttt tgcggcaacc
2085721 ccagcacatc ttcaacccgg ctgaacagtt cgcaggtaaa cgccacctcg gccggaccgt
2085781 gcatcttcgg cttgacgatg tagatggagc cggtgcggct gttgatcagc ggcccgttga
2085841 cgtcgctggc ctttagcccg tggatggcga tcaggccggt gaatagggca tccatgatgc
2085901 cttcgaacac ctcgctgccg tcagtgtcga cgatggcgtc attcgtcatc aagtgaccga
2085961 cgttgcggac gaacatgagg ctgcgtccag gcagcgtgaa ctggccaccg ccgggtgcgg
2086021 tgtagttccg gtccctattg agcacccgca ggaaagcggt gccgtccttg tctaccgctg
2086081 ctgccaggtc gcccttgttc aggccgagcc agttccgata acccagcacc ttgtcggcgg
2086141 cgtccacggc ggccaccgag tcctcgaagt ccatgatcgt ggtgatcgcg gattccagga
2086201 tcacgtcctt gacgccggcc cggtcggtgg tgccgacctg cgactccgga tcgatcagga
2086261 tctcgatgtg caaaccgtga ttgattagca gcaccgatgt cggcgactcg gctgcgccgg
2086321 tgtagccggc gaactggccg gggttggcca ggccggtgga cttatccggc aaggcaacca
2086381 cgagctggcc atcctgcact gtgaaaccgg tggcgtcgcc aaaggaaccc gacgacagcg
2086441 gaacactgtc gtcgaggaac ttgcgggcat acgcgatcac cttgtcgcca cgaaccttgt
2086501 tgtacgtggg gcctttttcg gcgccgtcgg tctcggggat gacatcggtg ccatacaagg
2086561 cgtcgtagag ggagccccag cgagcgttgg ccgcgttcag agcaaaccgc gcgttgagca
2086621 ccggcaccac cagctggggg ccggcggtcg tggtgatctc agcgtcgaca ccggacgtgg
2086681 tgatggtgaa gtcatcaggt tcgggaagca ggtagccgat ctcggtgagg aactggcggt
2086741 aggcatccat gtcgatgggc tcgatcaccc gacgccggtg ccacttgtcg atctgcgcct
2086801 gcagctcgtc gcgggcgttc aacagagctt ggttctgcgg ggtcaggtcg gcgacgacct
2086861 tgtcgacgcc cgcccagaag ctgtccgggt cgatatcggt gccaggcagg gcttcattgt
2086921 tcacgaagtc gtagagcacc cgagcgatgc gcaagttgcc caccgacacg cgatctgtca
2086981 ttgcttcctc ccttactggc aattgctcag cctaccggcc gacaagacga ctactacatc
2087041 cggcgacccg caaccgcagg tcacgtcaag ctctgtcagc acctcggcac ccggcatgct
2087101 cgctggctgg caacgcgacg cagtggccgc agcgatcata cgggtggggc ggtctgccta
2087161 ctacaatccc gttggatccg ttctggccgg acagcatccc gccgggagcg gctccggcca
2087221 cgtcggtgcc gctcattgcg gcggtgtgat tccgaatcag gccagacgct tgatccccgg
2087281 ataggagtcg aacccacggt cgaagctcat cagccgggta atgtcgtggt gagccatgac
2087341 ggcgatgtgt agtgcatccc tggccgacaa cgtttgatag cgcaacaggg catccctcgc
2087401 gtgttcgaca tcggtgcgct cgatcggcag cacttcgtcg accacgccga taattgcatc
2087461 gaaagccggc tgaatcgcct cacggcgttt gattgccaca taccggtggc atatctcctg
2087521 cagcacctcg gcgtcggtga ctaggcgttc accgcccgac agcgccgact ccagcagacg
2087581 ttgcgcgtcc agcttatgcg ggtgcgaggc acccaccaga tacatgggaa tgttggagtc
2087641 aacgaggatc accgtgatcc ttcgcgctcc gcaccgcgtc cgcgttcgat ttcctcgagc
2087701 atctgctcga cgtcggctgt cgggaactca tggcgtgcgg cggcacggac agatcgcagc
2087761 ttcatgtcta gatcgccgcg cggttctcgc tcccgcgcct cccgcagcgt ccggcggacc
2087821 cactcggaca ctgtcgtgcg gtgccggcgt gcaatctctc ggagttcttc ccactcgtcg
2087881 gggtccagca gaacctgcag gcgcttactc atagcatgag tgtatacagc tcatacgggt
2087941 gtatgaatcc agctcgcctg cgcgcgggag ctatcccccg ggggacccgt tctggccggc
2088001 cagcgttccg cccgtaccgc cgctgccgcc cggcccgcca gagtcgccgg gcccaccgtc
2088061 gccgccgtcg ccgatcaact gggcgtagcc gccgttaccg ccggtgccgg gggtgccgtc
2088121 cccgctgacg ccggcggcgc cgccattgcc accgttgccg atcaacccgg ccgtgccgcc
2088181 gttacccccg gtgccgccgg cgccggtgac gggtaccgcg actgagggaa tctgggttgg
2088241 cccaccggag ccgccggcgc caccgttgcc gaccagcagc gcgccgttgc ctccgttccc
2088301 gccactgcca ccgccggggg cgaagacgcc ggtaccggcg gacccggcgc ctccggcgcc
2088361 accgttgccg atcagcccga cggcgttgcc gccgtcgccg ccgtggcctc ggagaaagcc
2088421 gtcggtttgc acgctgttgc cgccgtcgcc gccgttgccg atcagcgtcc cgccggtgcc
2088481 gccgtcgccg ccgttgccat cgaagaagct gaacccgccg ttaccgccgt cgccgaacat
2088541 cccggcgtta ccgccggtac caccgtcgct gaaaccttgc agggtgctgc ctccggaacc
2088601 gccgtcgccg tacagccacc cgccgttgcc gccgttgccg ccgttgccga tgccggtggg
2088661 ggcggcaccg acggagccgc cgtcgccccc gttgccgatc agccgggcgt caccgcccgc
2088721 tccgccgtcg gcggctcccg atgggacatt gccgccgttg ccgccgttgc cgtacagcag
2088781 tccgccggtg ccgccggtgc cgccggcccc gcccgcgaag ccggccttgc cgagcccgcc
2088841 ggccccgccg gccccgccat ggccgaacag cccgacggcg gctccaccgg gcccgccgat
2088901 cccaccggta gcgccgacgg gtccggtacc gagtccgccg gcaccgccgt tgccgccgtc
2088961 gccgaagagc agtccgccga ccccgccggc accaccggca aggccggtcg ccccgggccc
2089021 gccgatgcca ccgttgccgc cgttgccgat caaccctgca tccccaccgg cgccgccggg
2089081 ctggccgatc ccgccgttgc cgccgttgcc gccgttgccg tacagcaacc cgccgggccc
2089141 gccgggctgt cccggcgcgc cattggcgcc atcaccgatc aacgggcggc cgaacaacgc
2089201 ctgaaacggc ccgttgagca cgtccagcgc ggcggcgtcc gccgcctcgg caccggcata
2089261 ggcccccgcg ccggcggtca tggcatgcac aaactgctcg tgaaacagcg ccgcctgcgc
2089321 actcaatgcc tgataggcct gggcgtgcgc gccgaacaaa tccgcaacag ccgccgacac
2089381 ctcatcggcg cccgcggcca gcacccccat cgtgggcacg gccgcagccg cattcgccgc
2089441 gccgatcgcc gacccgatgc cggccaaatc cgacgccgcc gccaccacca cttctggggc
2089501 cgccaccaca aacgacatga cgcgctcctc acgggaccgg gtgcgcagtc ccagcggtta
2089561 cagcgtattg acgtcccgcc accacgtccg gcgttcgggc caactgatcc gaaacgattg
2089621 tcagcggcag cagcccccga ttacgctcgg tgtcccgtca gacaccgatc cctgcgtcag
2089681 tcaacgatgc gtcccgtcgc gcatggtgcc aaccaggtcc tccaccacgt cctccagcgc
2089741 caccatcccc acgacagaac cgttgtcggc ggttaccaag gccagatggc tgttgatgcg
2089801 ccgcatccgc gacagggcgt cggccagcgg caacgattgg ggaacccgcg gcagcgggcg
2089861 cacaacggcc agatcgatca cggtttgcgg attgtcaccg agggtcagca cgtccttgat
2089921 gtgcagatat ccgatgaacc ttccaccgcg atccaccacc ggaaagcggg agtagccggt
2089981 ttgcgccaag gcctgttcga ccccgccgat ggtgggcccg gaccctaccg ccgacacctg
2090041 cactgcccga atgttgacca gcggcaccgc gacatcggca accaggcgag ttcgaatccg
2090101 aagggctcgg gttagccgcg tgtgctcctc gtgatccagc aggccttcgg atagcgattc
2090161 ggcgatcatc tcggacagtt ccgcagtgga gacggcgatg tcgagttcat ccttcggctg
2090221 caccccaacc agccgcagta tcgcgttggc gcagttgttg tagaacgcga tgaacggccg
2090281 ggcgaggcgc acgtagacca ggtacggcgg gaccagcaac atcgctgttc gctccggacc
2090341 agccaaagcg atgttcttcg gcaccatctc accgagcagg acatgcagcg ccaccacgat
2090401 cgccaacgac aaggtgtgca gcagcgccgg cggtacaccg ctcagcccga acgacagctg
2090461 tagcagcttg acgactgccg gttcgccgac ccggccaagc aggatcgagg acaccgtaac
2090521 ccccagctgt gcgccggtca gcatcgccgg gagctgttcg cccgcccgga tcacggtgac
2090581 ggcagtggcc ttgccctgct cggccagcgc ttcgaggcgg tcacgacgcg ccgagatcaa
2090641 cgcgaattcc gcgcccacga agaacgcgtt ggcgccgatc agcaaaagcg ccagcaacac
2090701 cgcggacagc acatccatca gcggccccgc cccgacccgg ggtcggcatg gccgcccatt
2090761 ttgatcaact ccaacaagtc gatccggcgc ccgtccatct ggatcacggt ggctaaccac
2090821 cgcatcgagt cgtcgggaag tccgtcctgg tccaaggcag tcagctcgac cgtttcgccg
2090881 gccaccggga tgtggccgag ctctcgaagc accaacccgc cgatcgtctc gtacggaccg
2090941 tcgggggctc gatagccggt ggcgctggcc acctcgtcga tgcgtagcag acccgagacc
2091001 cgccatccgt tgccggctgc caccacatcc ggtgtcgcat cgtcgtgttc gtcgcggacg
2091061 tcgcccacga tctcttcgat caagtcctcc agggttacca tgcccgcggt gccgccgtac
2091121 tcgtccacaa ccatggcggt ctgtagcgca ctggcgcgga cctgcgccat caccgcatcg
2091181 ccgtcgagcg tcgagggcac caccgcgacc ggctcggcga ccgtcgttag cagcgtgtgc
2091241 gcgcgatcgc cgggcggaac ctcgaacacc tgcttgacgt gcacgatgcc gacggtcgca
2091301 tcgagatctc cctcgaccac cgggaagcgc gagaatcccg atgcggccgc ggccgcaacc
2091361 aggtcggcga tggtgtcatc ggtctgcagc gccacgatct tcgaccgtgg cgtcatcagc
2091421 tcctcggccg tcagggcgcc gaactgcagc gagcggcgca tcagccacgc cgtggcgtca
2091481 tcgagtgcgc cgctgcgcgc ggaactacgc accaacgaca ccagctcctg cggtgtgcga
2091541 gctgagcgca gctcctcggc cggctcgatg ccaagtcgac gcacgatcca gttcgccgct
2091601 ccgttcgtga gacggatggc cggggtgagc agcagtgaga acagcacctg gccggccacg
2091661 actgagcgcg cggtgcgcag cgggcgcgcc accgcgagat acttggggac cagctcgccg
2091721 aagaccatcg acagcgatgt cacgatcacc agggcaaaaa acgtgataag accgtcggcc
2091781 acccgatcag acattccgac tgcgaccagc ccaggatgcg gtagctcggc caccagcggt
2091841 tcggtcaggt agccggtagc caaggtggtg atcgagatac ccaactgagc acccgaaagc
2091901 tggaacgaca gccggtggtg tgcgcgctgg atgaagcggt cccgactggt gccgccgcgg
2091961 gcgttggcct ccacggtgct gcggtccagc gcggtcagcg agaattcggc cgcgacgaac
2092021 acccccgtgc ctgcggtgag cgccaagatc gccaggatgg tggcgacggt atcggtgagg
2092081 ttcacgggcg gctcggtcgt cgcgctatat cgggccgagc cagtaccggc cgctcgcctg
2092141 gaaaaccgac ggtgtggacg ggtgcccgcg gcacgtcatc cctttcgctc gcaaccgcgc
2092201 agcgcgatac tgcgggtttg aagtacacat cgtagcgaga tagctcgtgg cgccagcttc
2092261 accagccggc gggcagcgga tggccctcgg caaagcccgc tcccgactgc acgcccacca
2092321 cggcccgctc atgcagctcc gccaggttcg aggcacccac ataggtgcag gtgctgcgca
2092381 cgccagaagt gatgtggtca attaggtcct ccacacctcc gcggtcgggg tcaaggccca
2092441 tccgcgacgt cgagatgcct tcctcgaaca acgccttacg agctcggtcg aacgggttgt
2092501 ccgcgccggt ccgggccacc accgcccgct tggatgccat gccgtagctc tccttgtacg
2092561 gctgatcgtc gcggtcacgc atcaggtctc cgggggattc gtaggtgccg gcgaaccacg
2092621 atccgatcat cacgttcgag gcgccggcgg ccagcgccag agccacgtcg cgtggatgcc
2092681 ggatcccgcc gtcggcccag atatgaccac cgagctgcct tgccgcagaa gcgcattcga
2092741 gcacagcgga gaactgcggg cggccgacac cggtcatcat tcgggtggtg cacatggcgc
2092801 cggggccgac accgaccttg acgacgttcg ccccggcttt cagcagatcc cgggtgccct
2092861 ccgccgacac cacgtttccc gccgccagcg gcaaacccaa gtccagtgcc gagaccgcct
2092921 tgatcgcgtc caaggtcttg acctggtgtc cgtgtgcggt gtcgatgacc agcacgtcga
2092981 cgccggcttc ggcgagcgct cgggccttag cgcccacgtc gccgttgatg ccgacggccg
2093041 cgccgatccg cagccggccc gcgctatcgg tggccggggt gtagataccg gcgcggatag
2093101 ccccggtgcg gcttagcact cccgccaacg tgccgtcggc gtcggtcagc accgcaacgt
2093161 cgaccggggc gtgctccagc aggtcgaaga tcttgcgtgg ctcggttccc gctggagcgg
2093221 tcacatagtc cgtcacggcg atatcgcgca cccgggtgaa gcgatccacg cccaggcagg
2093281 acgattcgcg caccaatccg atcgggcgac cctcgaggat gaccaccgcg acgccatgtg
2093341 cgcgcttgtg gatgagcgcc atggcgtcgg acaccgaatc gtcgggtgcc agcgtcactg
2093401 gggtgtcgag caccaggtcc cggcttttga cgaacgccac cgtctgcttt accgccggga
2093461 tcggcagatc ctgcggcagg attacgatgc caccgcggcg ggcgaccgtc tcggccatcc
2093521 gccgcccggc taccgcggtc atattggcga ccactaccgg aatggtggtg cccgagccgt
2093581 cggcggtgga caaatcgacg tcgaagcgcg acgcgacctc ggatcggttc ggaacgatga
2093641 acacgtcgtt gtatgtcagg tcgtacccgg gtgggtgccc gtctagaaat ctcatcactt
2093701 acccctttac ccccttttag ttctagcccg ctacaccggt acttcggtgc ggtctgaact
2093761 ccatagtgtg tggaacttgc ctggttcgtc gatccggccg taggtgtgtg cgccgaagaa
2093821 gtcgcgctgg gcctgggtga gtgcagcggg cagccgcgcg gtgcgcagcg cgtcgtaata
2093881 cgacagggcc gacgagaatc ccggggtcgg gatacccagt tgggccgccg tcgacaccac
2093941 acgccgccaa ctgtcgatcg ccgattcgac ggcgccgcgg aaatacgggg ccacaatcag
2094001 actggccagg ttcgggctgg cgtcaaaggc ttccttgatg tggttgagga acttcgcccg
2094061 gatgatgcag ccgccacgcc agatggtggc caggtcgccc ggcgtgatgt cccagccgaa
2094121 ttcggcgctg ccggcctgga tctggttgaa gccctgagcg taggccacga tcttggaggc
2094181 gtacaacgcc tggcggacgt cttcggtgaa cgtggcgggg tcggcgggct gctcgccgag
2094241 cttgcccgaa gccagaccgc tggcggccga gcgttgcccc acggatcccg agagagcgcg
2094301 ggcaaacacc gcttcggcga tgccggtcac cggcacaccc aggtccagcg cggacttgac
2094361 ggtccaacgg ccggtgcctt tctgctcggc ccggtccacg atgacgtcga cgagcggttt
2094421 gccggtcttg gcatcggtct gccgcagcac ctcggcggtg atctcgacca ggtagctgtc
2094481 cagatcgcca ttgttccact cggtgaacac atcggcgatc gccggcgcgg tcagacctag
2094541 cccgtcgcgc atcagctggt aggcctcacc gatgagctgc atgtcggagt actcgatgcc
2094601 gttgtggacc atcttgacga agtgcccgga gccgtccggg ccaatgtggg tgcagcacgg
2094661 cacgccgtcg acatgcgcgg agatctcctc gagcagcgga cccagcgatt ggtatgactc
2094721 ggcgggtccg ccgggcatga tcgacggccc gttcaacgcg ccctcttcgc cgccggagat
2094781 cccggccccg acgaagtgca agccccgctc acgcatcgct ttctcgcggc gcatggtgtc
2094841 ggtgtacaac gcattgccgc cgtcgatgat gatgtcgccg ggttccatgg cgtcagcaag
2094901 ttcgttgatg acagcgtcag cgtcagtggc ctctccggcc ttgaccatga tcagcacccg
2094961 acgcggtttt tccagtgcgg caagaaattc ggggatcgtt tcactgcgca cgaacttgcc
2095021 gtctgagctg tgctccttaa gcagcgcgtc ggtcttggcg accgaccgat tgtgcactgc
2095081 cacggtgtag ccgtgccggg cgaagtttcg ggcgatgttg gaacccatca cggccaggcc
2095141 agtgacgccg atctgcgcga tgccggctgg cgattccgac gaactcatgt cctgcctttc
2095201 agttgggccc ggcttcgcta ggcgatgaac agccgctgca gctgcgtgag ccacggtacg
2095261 gccagcgcga cggtgggcac caccaggacg gcggccgcag ctagatatgc ggccgcggac
2095321 agaaccgcgc tatttccacg ccccgacagc cggcgcacgc ggagcaccgt gctgggacct
2095381 ccgacggcca acgcacccga cggcgcccgc ccggacgcac aggcgaccaa tgcccgagcc
2095441 aggggagtgc gcccggcggc gcgcaccgcg gcgtcatcgg ccaggagctc gacgagtagc
2095501 tgcaccgccc ccagcgcatt ggcgctgcgg accaaccgcg ggaaagccgc gtgcaccgcg
2095561 gtaaacgcct ccaggacaag atcgtggcgg gcgcgtagat gagcccgctc atgggtaagg
2095621 atcgccgcga cctcggcgtc ggcgagcgcg gtcagtgtgc cttcgctgac cacaacccgg
2095681 ctacgcacac cgggcagaca gtaggcaagg ggctgcgcga cgtccaagac ccgaaggtcg
2095741 cgggcccgcg cgcacggctg ggcaagcgcg ccattgtgtc cgaccccgac gagatcgacc
2095801 accatgcggt ggtgtgcccg tcgtcgtcgc gtggcggtgg cgacgcgcac cacggcgacc
2095861 gccagccggg caccgaccag cacagtcaac gcaaagacgg tgatgtaggc cgcccacagc
2095921 ggccagccga ggcggccggc cgcgccgacg aagctggtcg tagggcgtcc gtcgggaccg
2095981 ggcatgagca gcctgctagc gatcgcgatt ccggcgctga acgacgacag caccgcggcc
2096041 agggcaatcg cctgccacag caccatggcg gcgcgcggtg cgcgcagtgg ccacgttgcc
2096101 cgggctagca gggctggggt cgggccagcc agcagcaccg cgaggatggt gaaggccagc
2096161 gcggacacgc cgttagtctc cctcaagtct ccgttgccgc gccagccggt ggccgattgc
2096221 catgaccggc ttccaattcg gcgagcgcac gtcgtagcgc atccgcctcg tcggcaccga
2096281 ctcgctcgac gaagtgcacc agcgcggctt gcctgctgcc ggagtcctcg gcctgagcca
2096341 atgcatcgac catcagcccg gcgaccaatt cgtcgcggcc gtgcacggga gcgtagcggt
2096401 gggctcgatc gtcgcggatc tgcagcacga ggttcttctt tgccaaccgt tgcagcacgg
2096461 tcatcaccgt cgtgtaggca aggtcgcggc gcgccgacaa cgcttcgtgg acttggcgaa
2096521 cggtttgggg ttccgtcctg gaccacaaat ggtccatgac cgcgcgttcc aaatccccca
2096581 accgtgtcag cttggccatt gttcgttcat ctcctgcggg ttgaaaccag cgtactccgg
2096641 cttactactc gctgtcgtat ccaaaccggc gggcggccgt accgggccta tgcacccggc
2096701 tcgcaaacat tacacgctaa cgcttgctaa attagggcag ccttgcctat cattacttcg
2096761 tcgagccaca acgaccgcgg ccgagtcctg agggctgcag tgacccccgg tcgactcgat
2096821 cggcgagccc cgtgccttgg tgcacggggc tcgcccgttg gtgtagacac aaggacgtgc
2096881 agccatcgcc ggactcaccc gctccgctga atgtcaccgt gccgttcgac agcgagttgg
2096941 gtttgcaatt caccgaactg ggtcccgacg gggcccgagc gcagctcgac gtccggccca
2097001 agttgttgca gctgacgggc gtcgtgcacg gcggtgtcta ctgcgcgatg atcgagagca
2097061 tcgccagcat ggcagccttt gcctggctca attcgcacgg cgaaggcggg agtgtggtcg
2097121 gcgttaacaa taatacggat ttcgtgcgct ccatcagctc agggatggtg tatggcaccg
2097181 ccgaaccgct gcatcggggt cggcggcaac agctgtggct ggtcaccatc accgacgaca
2097241 ccgaccgggt ggtcgcccgc ggccaagtgc ggctgcagaa cctcgaggcg cggccttaac
2097301 ccgctcgaaa ccgttgaacc tgccgcggcg tggcaggatc gcagagcatg cgcctgacgc
2097361 cgcacgaaca ggagcgtttg ctgttgtcct acgccgccga gttggcccgc cggcgtcggg
2097421 cccgcggcct gcgcctcaat catccggaag ccatcgcggt gatcgccgac cacatcctgg
2097481 aaggcgcgcg tgacggccgc accgtcgcag agttgatggc atccgggcgt gaggtgctcg
2097541 gccgtgacga tgtgatggag ggagtgccgg agatgctcgc cgaggtacag gtggaggcga
2097601 cgtttccgga cggcaccaag ttggtcaccg tgcatcagcc gatcgcatga ttcccggaga
2097661 aatcttttac ggcagtggtg atatcgagat gaacgccgcg gcactctccc gcctgcagat
2097721 gcggatcatc aacgccggcg atcgtccggt gcaggtcggt agccacgtcc atctcccgca
2097781 ggccaatcgg gcgctgtcat tcgaccgtgc gacggcccac ggctaccgtc tggacatccc
2097841 ggcggcgaca gcggtgcgct tcgagccggg cattccccaa atcgtcgggt tggttccgtt
2097901 gggcggacgg cgcgaggtac ccggtctgac gctaaatccg cccggacggt tggaccgctg
2097961 atggcgcgac tgtcaaggga gcgctacgca cagctgtacg gacctaccac cggcgaccgg
2098021 atacggctgg ccgacaccaa cctgctggtt gaggtcaccg aagaccggtg tgggggaccg
2098081 ggactggccg gtgacgaggc ggtgttcggc ggcggcaagg tgctgcgcga gtccatgggc
2098141 cagggccgtg cgagccgggc cgacggtgcc cccgacaccg tgatcaccgg tgcggtgatc
2098201 atcgactact ggggaatcat caaggccgac atcgggattc gcgatggccg catcgtcggg
2098261 atcggaaagg ccggcaatcc cgacatcatg acaggtgtgc atcgggatct cgtcgtcggg
2098321 ccgtccaccg aaatcatcag cggcaaccgt cgaatcgtca ccgcaggcac cgtcgactgt
2098381 cacgtgcact tgatctgtcc gcagatcatc gtcgaagcct tggccgcggg caccaccacg
2098441 atcatcggcg gtggcaccgg acccgccgag ggcaccaagg ccaccacagt cactcccggc
2098501 gagtggcacc tggcccggat gctggagtca ctggacggtt ggccggtgaa cttcgcgctg
2098561 ctcggcaagg gaaacaccgt gaatcccgac gcactgtggg aacagttgcg cggtggcgca
2098621 tcgggtttca aactccacga agactgggga tcgaccccgg cggccatcga cacctgcttg
2098681 gcggtcgccg acgtggccgg ggtgcaggtt gcgctgcact ccgacactct caatgagacc
2098741 ggattcgtcg aggacaccat cggcgcgatc gccggacgtt cgattcacgc ctaccacacc
2098801 gagggcgccg gcggcgggca cgcaccggac atcattaccg tcgcggcgca accgaatgta
2098861 ctgcccagct cgaccaatcc gacccgcccg catacggtga acacccttga cgagcatctc
2098921 gacatgctga tggtgtgcca ccacctcaac ccccggatcc cggaggacct cgcgtttgcc
2098981 gaaagccgga tccgaccgtc caccattgcg gcagaagatg tgttgcacga tatgggggca
2099041 atctcgatga ttggcagcga ttcccaggcg atgggccgtg tcggcgaggt ggtgctgcgc
2099101 acctggcaga ccgcgcacgt gatgaaagcc cgccgcgggg cactggaagg tgacccgtct
2099161 ggtagccaag ccgccgacaa caaccgggtc cgccgctaca tcgccaaata caccatctgc
2099221 ccggccatcg cacacggcat ggatcacctg atcggttcgg tggaggtggg aaagttggcc
2099281 gacctggtgt tgtgggagcc ggcgtttttc ggggttcgcc cgcacgtcgt gctcaaaggt
2099341 ggggcgatcg cctgggcagc gatgggcgat gcgaacgcgt caatcccgac cccgcaaccg
2099401 gtgctcccgc gaccgatgtt cggcgcggcc gcggcaaccg cggcggcgac ctcggtgcac
2099461 ttcgtcgcgc cgcaatccat cgacgcgcgc ctggcggacc ggctcgcggt caatcgggga
2099521 ctagcgccgg tggccgacgt gcgcgcagtg ggcaagaccg acctgccgct caatgatgcc
2099581 ctaccgagca tcgaggtcga tcccgacacc ttcaccgtgc gaatcgacgg ccaggtgtgg
2099641 caaccgcagc cggccgccga actacctatg acacaacggt atttcctgtt ctaatgacct
2099701 cgctggccgt gctgctcacc ctcgccgact cgcggctgcc cacgggtgcg cacgtgcact
2099761 cgggcggcat cgaagaagcc atcgccgccg gcatggtgac cggcctggcc accctggaag
2099821 cgttcctgaa acggcgggtc cgcacccacg gcctgctgac ggcgtccatc gcggccgcgg
2099881 tgcaccgggg cgagctggcc gtcgacgacg ccgaccggga aaccgacgcg cgcacaccgg
2099941 ctcccgcggc cagacacgcc tcacgcagcc agggccgcgg gctgatcagg ctggcacggc
2100001 gggtgtggcc cgattccggc tgggaggaac tgggcccgag gccgcatctg gcggttgtgg
2100061 ccggacgggt cggcgcgctg agcgggctgg cgcccgagca caacgccttg cacctcgtct
2100121 acatcacaat gaccggctcg gccatcgccg cccagcgact gctggcgcta gatcccgccg
2100181 aagtgaccgt ggtgaccttc cagctgtccg aactgtgcga gcagatcgcg caggaggcca
2100241 cagccggact ggcagacttg tctgatccgc tgctggacac gctcgcccag cggcatgacg
2100301 agcgcgtgcg tcccctgttc gtttcctgaa aggtaaggca tggcaacgca ttcccatccc
2100361 cactcgcaca ccgtgcccgc tcggccaagg cgggtccgca aaccgggcga gccactgcgc
2100421 atcggcgtcg gcggcccggt cggctccggc aagaccgcac tggtggcggc gctgtgccgg
2100481 caattgcggg gagagctgtc gctggcggtg ctgaccaacg acatctacac caccgaagac
2100541 gccgacttct tgcgcacaca tgcggtgctg ccagacgacc ggatcgcggc cgtgcagacc
2100601 ggcggctgcc cgcacaccgc gatccgcgac gacatcaccg ccaacctgga tgcgatcgac
2100661 gagttgatgg ccgcccacga cgcgttggac ctgatcctgg tcgaatccgg cggcgataac
2100721 ctcacggcca ccttctcttc ggggctggtg gatgcgcaga tcttcgtcat tgacgttgcc
2100781 ggcggcgaca aggtgccgcg caagggcggg ccgggggtga cctattcgga tttgttggta
2100841 gtcaacaaga ctgacctggc tgcattggtg ggcgccgacc tggcggtgat ggcccgcgat
2100901 gcggacgcgg tgcgcgacgg ccgcccgacg gtgctgcaat cgttgaccga ggacccagct
2100961 gccagcgatg tcgtggcctg ggttcgtagt caactggccg ccgatggagt ctagtgttct
2101021 ggtggtcgcg tcgccgaatc ggttgccgcg catcgactgt cggggcggtg tccaggcacg
2101081 ccgaaccgcg cccgacacgg tgcacctggt gtcggcggcc gcgaccccgc tgggcggtga
2101141 caccatgaga atccgggtga tcgtggaacg gggtgcccag ctacggctgc gtagtgccgc
2101201 cgcgacggtg gccttgcccg gcgtggatac cctgacgtcg catgctcact gggagatcga
2101261 cgtgaccggc accctggatg tggacctgga gccgacggtc gtcgccgcct cagcccggca
2101321 tctgtcgcat gccaccttgc gcctgcacga cgacggtcgg gtccgcttgc gcgagcgcgt
2101381 gcagattggc agatgcaatg agcgcgaagg attttggtcg tcatcgctgc aggccgatcg
2101441 gcatggtcgt cccctgctgc ggcaccgggt ggaactgggt gccgggtctt tggccgacga
2101501 cgtcattgcg gcgccgcgcg ccactatcag cgagctgcgc tatccggcga cggcattcac
2101561 cgacgccatc gacgcacggt cgaccgtttt ggcgttggcg ggtggcggaa cactgagtac
2101621 ctggcaggct gaccggttgc ctggctaacg ctagctggcc accttagcgc ttgccgctga
2101681 gccctgcgcc tcggcggcca gctcggccag ctgttcgagc cgcgttcgcg caaatgcctg
2101741 ctggtcggtg atggtcagct ggccgcggcg agtactgagg aaagtcaccg tccacgacag
2101801 cagagtggtg atcttggtct tgaacccgat caggtacgcc aggtgcagca ccagccaaat
2101861 cagccaggcg ataaagccgc tgaactcaac gggaccgatc ttggccaccg ccgaaaacct
2101921 cgaaaccgtg gccatcgatc ccttgtcgaa gtactggaat ggctcacgct ccgccgggtt
2101981 ggcgccggcc agttcggcct tgatcgtgct ggcgacgtat ttcgccccct ggatggcgcc
2102041 ctgcgccaca cccggcacac cctccacagc ggccatatcg cccaccacga acacgttcgg
2102101 gtacccggga atggacaggt cgggcagcac ttggacccgg ccggcccggt cgagctcaac
2102161 ccgtgattgc tcggcaaggt ccctgcccaa ccgactggcc gaaaccccgg ccgaccagac
2102221 cttgcaggcc gactcgatgc gccggacggt gccgtcggag tccttgacgg tgatgccgtt
2102281 gcggtcgacg tcggtgacca tcgcacccag ctggatttcc acgcccagct tctgcaaccg
2102341 ggcagccgcc cgctgaccga gctttgcgcc catcggtggc agcaccgccg gggcggcgtc
2102401 aagcagaatc acccgcgcct tggtcgagtc gatgtgccgg aatgcgccct tcaacgtgtg
2102461 ctcggccagc tcggcgatct gtccggccat ttcaacaccg gtggggccag ccccgacaac
2102521 ggtgaatgtc agtagcttgg cccgccgttc cggatcgctg gaccgttcgg cttgctcgaa
2102581 agcgctcaat atgcggccac gcaactccaa cgcgtcgtcg atggacttca tgccgggtgc
2102641 gaattcggcg aaatggtcgt tgccgaaata agactggcca gcacccgcgg cgacgatcag
2102701 gctgtcgtag ggggtttggt aggtgtgacc gagcaattcc gagacgacgc actgcccggc
2102761 caggtcgatg tgggtgacgt tgcccaacag tacctggaca ttgcgctgct tacgcagcac
2102821 gacccgggtc ggcggagcga tttctccctc ggagataatc ccggtggcca cttggtacag
2102881 cagcggctgg aacaggtgat gggtggtgcg cgcgatcagc ttgatgtcaa cgtcggcccg
2102941 cttgagcttc tttgccgcgt ttagcccgcc gaacccagat ccgatgatca caactcgatg
2103001 cctacgaggt ggttgcgctg tgggttcttg ctggggactc atgttccgct gctcctgacg
2103061 gggtcacctc gatgagcgag ttcagttagc tactacggta gtcaacccga ccgctgcagg
2103121 cccagttgag gacatgtgtc atcagccaca ccacagcgtg cctgcgtcac cggcccccgg
2103181 tggctacaca cccagcagcg ggcgcagcgc ttcagcggcg gtggtgatga ccccgggcag
2103241 atagccgtgc ggagccaagt tgatgattaa tccgtcgaca ccggcatcga gcaccttggc
2103301 ctgaatttgg tcggcgatct gtgccgggct gcccaccacc acgcgaccgc tcatctccgc
2103361 gggaatcgca tctggcgaga gtgtctcgtc gatcatcacc gtcaacagca ggctggtctg
2103421 aagcgtcgac cggtcccggc cggcctcgtc gcaccgcgcg gccagcgccc gcatcttgcg
2103481 cggcagctcg tcgaccgccg ccacgatgtt gagatggtcg gcaaagcggg cggcgatcgc
2103541 gaatgtcttt ttctcaccac cgccgccgat caagattggg atgcggtcgc gataccgcgg
2103601 ctcggccatc gccgattcgg tggtgtacca atcgccgaaa aacgttgggc gctcaccctt
2103661 gaccattggc tcgaggatct gtagcgcctc ttcgagccgg ttgaaccggt cactgaaagt
2103721 gccgaactcg aagccgagct ggcggtgttc cagctcaaac caaccggctc caatgccgag
2103781 gatcgctcga ccggcgctaa ccacgtcgag cgtggtgatg atctttgcca gcagggtcgg
2103841 gctgcggtag gtattgccgg tcaccaacgc gcccagttgc agccgctcgg tcgccgtggc
2103901 cagcgcacca agggccgtgt aggcctccag catcggctgg tcgggcgtcc ccaacatggg
2103961 cagttggtag aagtggtcca tcacaaacag ggagtcgtaa ccagccgctt cggcctcacg
2104021 cgcttgagcg atgacggacg ggaaaagctt ctccacccct gtgccgtagg agaagttggg
2104081 gatctgtaga cccagccgaa tagtcacact acctaccgta gcgatcggcc ggtgaagcga
2104141 aaggttcagc cgaagtgagc cagcgcgccg tggctgacgt gcagcgtctg gccggtgatg
2104201 tggcgagccg caggggtggt aaggaacagc gccagccgcg caatctcggc cgcgacgggc
2104261 gcgggtgtgc gcgaaagccc ttcgtaaccg gtctgcacgc tgcggccgca agcgactgta
2104321 ttgatggtga tcccgcgcgt gccgaaaacg gcggcctggc ccgcgatcca attcgagagg
2104381 gccgctttga tcgcggactc ggcgccaccg gcaggcgggt tctccgccac cacgctgaca
2104441 atcgagccgc cggagcgcag gtgatcgccc acggattgca ccgtcagcac caccgagagc
2104501 accgtcgcgt cgagcgcatt gcgccaggcg ttggccgtgt cggacaccga gtaggcgcgc
2104561 gggtcaccgg catcccagga cggcgctggc acgttgacga tggtgtccag gtgacggggg
2104621 aacagtcccc gtgcctcggt gaggctggtc gggtcggtgg tgtcgcacac aacggcgtcc
2104681 acgtcgagtt ccttcgcggc gacctcgagg tcgccgcggc gggcacccac cagggtgacc
2104741 ttgtggccgt cgttgcgaaa gccttcagcc attgtgcgcc cgagatcggt atccccgccg
2104801 gtgaccagca cctccactgc catgacctcc tcgtgttcaa cgctgaaccc agaccctgga
2104861 ccgttgcctg gaatcgcatc gtgatggcgt aagctccggt agatgttact ggacagtagc
2104921 tattcgggga aactccgcac cgccacgacg cgcagacgat cttggtaacc attaggtttg
2104981 gccagtgcgt tggatcggac tgtcaactgg cctagtgtca gcgatgctgg tcgcgggcct
2105041 ggtggcatgt ggatcgaatt cacccgcatc gtcgccagcc gggccgacgc agggtgcccg
2105101 gtcgatcgtg gtgttcgcgg ctgcctcgct gcagtctgcg ttcactcaga tcggtgagca
2105161 gttcaaagcc ggcaacccag gggttaacgt caacttcgct ttcgctggtt cttctgagtt
2105221 ggccacccag ctgacccagg gcgcgaccgc cgacgtcttt gcatctgcgg acaccgcgca
2105281 aatggacagt gtggccaagg cggggttgct ggccggtcat ccgacaaact tcgccaccaa
2105341 cacgatggtc atcgttgccg ccgcaggcaa tcccaagaag atccgatctt ttgccgacct
2105401 cacgcggccg gggctcaacg tggtggtctg ccagccgtcg gtgccatgcg gatcggcgac
2105461 ccggcgcatc gaagatgcaa ccgggattca tctcaacccg gtcagtgagg aacttagcgt
2105521 gaccgacgtt ctgaacaagg tcatcaccgg gcaagccgat gccgggctgg tctatgtcag
2105581 tgacgcgctc agcgttgcca ccaaagtgac gtgtgtcaga tttcccgaag ccgcgggtgt
2105641 ggtcaatgtc tacgccatcg cggtgctaaa gcggacctcc cagcccgctc tggcccggca
2105701 gttcgtggcc atggtgaccg ctgcggcagg tcggcggatc ctggatcagt cgggtttcgc
2105761 caagccctga cgatgcaccc gcctacggat ctgcctcgtt gggtatatct cccggcgatc
2105821 gcggggatcg tgttcgtggc aatgccgctg gtcgcgatcg ccatccgggt cgattggccg
2105881 cgtttctggg cgctgatcac tactccgtct tctcaaacgg ccctgctgtt gagcgtgaag
2105941 accgccgcgg ccagcacggt gctgtgcgta ctgctgggcg tcccgatggc gctggtgctg
2106001 gcccgcagcc gcggacgact ggtgcggtcg ttacgaccgc tgatcctgtt accgctggtg
2106061 ctgccgccgg tagtcggggg tatcgcgttg ctctacgcgt tcggccggct cggcctgatc
2106121 gggcgctacc tggaggcggc cggcatcagc atcgcattca gtaccgcggc tgtggtgctg
2106181 gcgcagacct ttgtctcgct gccgtatctg gtgatttccc tagagggtgc agcccgcacc
2106241 gccggagccg actacgaggt ggtggcggcg acacttgggg cgcggcccgg cactgtctgg
2106301 tggcgcgtga ccctgccgtt gctgctcccg ggcgtggtgt ccggatcagt actggcgttt
2106361 gcccgctcgc tcggagagtt tggcgcgacc ctaacctttg ccggttcccg gcaaggggtc
2106421 acccgtaccc ttccgctgga gatttacctg cagcgggtga ccgatccgga cgcggcggtg
2106481 gcattgtcac tgctgctcgt tgtggtagcg gcactggtgg tgctgggtgt gggtgctcgt
2106541 acgccgatcg ggaccgatac caggtagccg gtcatgagca agctgcagct gcgcgcggtc
2106601 gtcgccgacc ggcgtttgga cgtcgaattc tcggtgtccg cgggcgaggt gcttgcagtg
2106661 ctcgggccca acggtgcggg caagtccacc gccctgcatg ttatcgcggg gctgcttcgc
2106721 cccgacgcgg gcttggtacg tttgggggac cgggtgttga ccgacaccga ggccggggtg
2106781 aatgtggcga cccacgaccg tcgagtcggg ctgctgttgc aagacccgtt gttgtttcca
2106841 cacctgagcg tggccaaaaa cgtggccttc ggaccacaat gccgtcgcgg gatgtttggg
2106901 tccgggcgcg ctaggacaag ggcgtcggca ctgcgatggc tgcgcgaggt gaacgccgag
2106961 cagttcgccg accgtaagcc tcgtcagcta tccgggggcc aagcccagcg cgtcgccatc
2107021 gcgcgagcgt tggcggccga accggatgtg ttgctgctcg acgagccgct gaccggactc
2107081 gatgtggccg cggccgcggg tatccgttcg gtgttgcgta gtgtcgtcgc gaggagcggt
2107141 tgcgcggtag tcctgacgac ccatgacctg ctggacgtgt tcacgctggc cgaccgggta
2107201 ttggtgctcg agtccggcac gatcgccgag atcggcccgg ttgccgatgt gcttaccgca
2107261 cctcgcagtc gtttcggagc ccgtatcgcc ggagtcaacc tggtcaatgg gaccattggt
2107321 ccggacggct cgctgcgcac ccagtccggc gcccactggt acggcacccc ggtccaggat
2107381 ttgcctactg ggcatgaggc aatcgcggtg ttcccgccga cggcggtggc ggtgtatccg
2107441 gaaccgccgc acggaagccc gcgcaatatc gtcgggctga cggtggcgga ggtggatacc
2107501 cgcggaccca cggtcctggt gcgcgggcat gatcagcctg gtggcgcgcc tggccttgcc
2107561 gcatgcatca ccgtcgatgc cgccaccgaa ctgcgtgtgg cgcccggatc gcgcgtgtgg
2107621 ttcagcgtca aggcgcagga agtggccctg cacccggcac cccaccaaca cgccagttca
2107681 tgagccgacc cgcgccgtcc ttgcgtcgcg ccgttaacac ggtaggttct tcgccatgca
2107741 tcaggtggac cccaacttga cacgtcgcaa gggacgattg gcggcactgg ctatcgcggc
2107801 gatggccagc gccagcctgg tgaccgttgc ggtgcccgcg accgccaacg ccgatccgga
2107861 gccagcgccc ccggtaccca caacggccgc ctcgccgccg tcgaccgctg cagcgccacc
2107921 cgcaccggcg acacctgttg cccccccacc accggccgcc gccaacacgc cgaatgccca
2107981 gccgggcgat cccaacgcag cacctccgcc ggccgacccg aacgcaccgc cgccacctgt
2108041 cattgcccca aacgcacccc aacctgtccg gatcgacaac ccggttggag gattcagctt
2108101 cgcgctgcct gctggctggg tggagtctga cgccgcccac ttcgactacg gttcagcact
2108161 cctcagcaaa accaccgggg acccgccatt tcccggacag ccgccgccgg tggccaatga
2108221 cacccgtatc gtgctcggcc ggctagacca aaagctttac gccagcgccg aagccaccga
2108281 ctccaaggcc gcggcccggt tgggctcgga catgggtgag ttctatatgc cctacccggg
2108341 cacccggatc aaccaggaaa ccgtctcgct cgacgccaac ggggtgtctg gaagcgcgtc
2108401 gtattacgaa gtcaagttca gcgatccgag taagccgaac ggccagatct ggacgggcgt
2108461 aatcggctcg cccgcggcga acgcaccgga cgccgggccc cctcagcgct ggtttgtggt
2108521 atggctcggg accgccaaca acccggtgga caagggcgcg gccaaggcgc tggccgaatc
2108581 gatccggcct ttggtcgccc cgccgccggc gccggcaccg gctcctgcag agcccgctcc
2108641 ggcgccggcg ccggccgggg aagtcgctcc taccccgacg acaccgacac cgcagcggac
2108701 cttaccggcc tgaccggatc cggccgcacc ccaagtgata cccctgggcg gggtgtcagc
2108761 gcggccgggc gctcttgagc cggcgcagcg gcgtccatgg agcgccgccg gccaacgcgg
2108821 cgttcttggc gccggcgcga acgttgttca ggtgccaacc ggtggtgggt cgtggttggc
2108881 gacttgtaca gcttccggtt ctccataggt cgcgccgggg acgggcagcg ggtcgtgtgc
2108941 gcgtctttca gtgcaccgtg cgaaacgccg acaccgttga actccacctg aaagcaccgc
2109001 tgaacagcag aaaagcgccc acgaaaacac cgtggggcgc cacacacgtt tgatcacgcc
2109061 acaacccacc gacaccgtca ctaccctcaa atcgttacgc agaagcggta taccgatatc
2109121 acggccctgt gctgggctaa gccagcgtct gcaaggagaa ccgcatggac atcacggcaa
2109181 caaccgaatt ttccgccatg aacctcgacg gcaagacggg tataggttgg ctcggctaca
2109241 tcgtcatcgg cggtatcgcc ggctggctcg ccagcaagat cgttaagggg ggcggctcgg
2109301 gcatcctgat gaacgttgtg atcggcgtcg tcggggcatt cggcgccggc ttggtcctta
2109361 acgcgctggg cgtcgacgtc aaccatggcg ggtactggtt caccttcttc gtcgccctgg
2109421 gcggggctgt cgtcctgctg tggatcgtcg gcatggtgcg caagacctag cgccaaactg
2109481 ttgtcggcca tgcaaattga gtgtgactgc ggcggccggc gacggtagcg gcatgatgga
2109541 gtgatggtct caccggcgac cacggcgacg atgagtgcgt ggcaggtgcg tcggcccggc
2109601 ccgatggaca ccggcccgct cgaacgagtg accacccggg tgccgcgccc ggcgccatcg
2109661 gagttgctgg tggccgtgca cgcatgcggg gtgtgccgca ccgatctcca cgtgaccgaa
2109721 ggtgacctgc ccgtgcaccg cgaacgggtg attcccggcc acgaggtagt gggagaggtc
2109781 attgaggtgg gctcagcggt gggcgcggct gccggtggcg aattcgaccg aggagaccgg
2109841 gtgggtatcg cctggctgcg tcacacttgc ggggtctgca agtactgccg gcgcggcagc
2109901 gagaacctct gcccgcaatc ccgctacacc ggctgggacg ccgacggggg atacgccgaa
2109961 ttcacgacgg ttcctgcggc tttcgcgcac catctgccga gcggctatag cgacagcgag
2110021 ctggcgccgt tgttgtgcgc cggcatcatc ggatatcgat cgctgctgcg caccgagcta
2110081 ccacccggtg gccggctggg tctctacgga ttcggcggca gtgcccacat caccgcccag
2110141 gtcgcgttgg cgcaaggcgc cgaaatacat gtgatgacac gcggggcccg cgcgcgcaag
2110201 ctggcgctgc aacttggcgc tgcatcggct caggacgccg ccgaccggcc acccgtgccg
2110261 ctggacgccg cgatcttatt cgccccggtc ggggatctgg tgctgcccgc gctggaagcg
2110321 ctggaccgtg gcggcatctt ggcgatcgcc gggatccacc tgacagatat tccggacctg
2110381 aactaccagc agcacttgtt ccaggagcgt cagatccggt cggtcacgtc gaacacccgc
2110441 gccgatgcgc gcgcgttctt cgacttcgcc gcccagcatc acatcgaggt caccacgccg
2110501 gagtacccgc ttggccaagc cgatcgtgcg ctgggcgacc tgagcgccgg ccgcatcgcc
2110561 ggtgccgccg tgctgctgat ctgaccgagc tcaggtcgac aggtgccaga ccagggcagc
2110621 ggccagggca cccatcccgt tcagcgacca atgcagtgcg atcggtgcga tcaggctgcc
2110681 gctgcgccgt cgcagccagc tgaacacgaa tccggccact ccggtggcca acaccgccag
2110741 catgacaccg gccaccagcc cgatgatccc gccaccgaac agtcgagtga agccgacatt
2110801 gctgctcgtg agccccagcg acgtcgcaat atgccacaga ccgaacagca ccgaacccgc
2110861 caccgcgaca ccccggaatc cccaagcccg attcagcgcc ccatgcaaca caccgcggaa
2110921 ggccagctct tcggggatga cggtttgcag cgggatcatg accatcgagg cgatcaccgc
2110981 gccggagatc gtcgcgtagt gatggttcat gaacatcggc cgggttatcg gcagcaggac
2111041 acctaccgag atcaccgcca ccaccagggc aacggccgct agcgcataga cgagcccgga
2111101 tttccagtgt tggcggctca gtccgagttc agcccagccc aggcctctac tccgcaccaa
2111161 gatcaccagt ccgaccgcgg cggccgggac ggtggcgatg ctcgcccacg gtgtggtgaa
2111221 atgcgcgatc aggttcgtca gtaccagcac caggacgacg acggcgatgt cgacatatat
2111281 ccggaaccgg tgcatcaccg agaggtgcga caccagtgga cctggatgaa cggctgcgca
2111341 agcagtcaag tggtcagaca tcgtcagcag agtctaccgg cggagggctc ggtgtccgct
2111401 ctcgcgcgta ggccttgagc tcggctgcga gcgcgtctgc cgccaacagc tggggaagca
2111461 gctccgattc agaggttcgg gcgcgaaaca cgagcccgac ggtcacgttg tgctcagggc
2111521 ggtaatcgac ggtgattgtg tcgccggcgc gcactgttcc gggagcgatc acccgtaggt
2111581 aggcgcctgg tttggcggcc cgggtgaagg tcttgatcca ataacgcaaa tccaggaagg
2111641 ccgcgaaggt ccggcacggg atccggggcg ccgagacttc caacaccaat ccgtcggagc
2111701 cgatgcgcca gcgttcacca atccgcgcgt acgtcacgtc gacgcccgag gtggtcagat
2111761 tctcgccgaa cattccgttg tgaagggtgc ggtgaagctg ggtttcccac gcgtcgaggt
2111821 cttctcgcgc atacgcatag acggcctgat catcaccgcc atggagcttc gggttgccga
2111881 cggtgtcgcc aaccaggccg ctgccgacac ccgcatgcat cgacccgggt gcccgcacca
2111941 tgaccgcctc agatgccgcc actttgtcga ttccggtcaa cttcgactgc gcgcgcggat
2112001 cagggttcgc ccgaacacga gccaggttga ccgacaacac atgcgccacc cgcacagggt
2112061 agctctgacg cgcgttggtc cacgccagcc ggcgcggcgc aacggtcact cctcgccgcg
2112121 agcccgagcc tcgtaggtcc tgcgcttctc catgtcgaca tcgtcggtga agacatgctc
2112181 gccgccgagg agtcggttca agccctcgga aacctggcgc ggcatgaacc gctgtgccac
2112241 gatcatcgag ccagccgctt tcgtgacccg cacccgcggt ttgggatgaa caatcagccc
2112301 gacgatcgcg tcggcgatat cggccggctc ggcgttcttg aatcctttga tcccaccggt
2112361 gcccgcaatg agctcggtgt tgacaaacga cggcaacacc atcgagaact tcacgccggc
2112421 cgaacggtat tcaagcctgg ccgaatcggt gaacgcgacc accgcgtgct tgctggcaca
2112481 gtaagtggcc acgcctacgg cgtagatttc cccggcaagc gaggcgacat tgataacgtg
2112541 tccccgcccg cgcgggacca tccgctgcgc cgccagcttg ctacccaaga tcaccccgta
2112601 gacgttgatg tccaggattc ggcgggttac cgggtctggt tcgtcgacaa tccgccccac
2112661 gggcatgatg ccggcgttgt tgaccagcac gtcgatcggg ccgagttggc gctcgacggc
2112721 gtcgaggaat cccgaaaacg aatccgggtc ggtgacatcg agtttgccgt acatgtcgag
2112781 gtcgagatcg gcacccgact ctttcgccat cgcctcatcg atgtcgccga tagcgacctt
2112841 ggctcccaag ttgtgcagcg cggccgctgt ggccaatccg atcccccggg cgccgccggt
2112901 gatggcgatt actttgtcct ggaccttgtc ccggatcttg acgccgatgg atgtcctgcc
2112961 tggcactgtc gtcccttcgc tcggcgggcc ttagccgccg tccaatgcgg tcgcgcccgt
2113021 gtagtcacgg tagccgcgaa cgccgatgaa acagctacgg tgtgcacgtg cccgaacgat
2113081 tgctcgatgc cgtgcgtgtg ctcgacttgt ccgacggctg ttctgctgga ggcaccgata
2113141 tggtgacacg actgctcgcc gacctgggcg cagacgttct caaggtggaa ccccccggcg
2113201 gcagcccagg acgccacgtg cggcccacgc tggccggcac cagcatcggg ttcgccatgc
2113261 acaacgcgaa caaacgcagc gcagtgctca acccgctcga cgagagcgac cgtcggcggt
2113321 tcttggacct cgccgccagc gccgacatcg tcgtcgactg tggtcttccg ggacaggccg
2113381 ccgcgtacgg ggcatcgtgt gccgagttgg ccgatcgcta ccgacacctg gtggcgctgt
2113441 cgatcaccga ctttggcgct gccggtccgc ggtcgtcatg gcgcgcgacc gatccggtgc
2113501 tgtacgcgat gagtggtgct ctctcgcggt cgggccctac cgccggcacg ccggtactgc
2113561 cgccggacgg tatcgcttcg gcaaccgcag cggtgcaggc agcctgggcc gtactggtcg
2113621 cctatttcaa ccgattacgt tgtggtactg gggattacat cgacttctcc cggtttgacg
2113681 ccgtcgttat ggcgttggat ccccccttcg gggcgcacgg gcaggtcgca gccggcatcc
2113741 gcagcaccgg gcgatggcgg ggacggccca agaaccagga cgcttacccg atttatccgt
2113801 gccgggacgg ctacgtacgg ttctgcgtga tggcgccgcg gcagtggcgc gggctgcgcc
2113861 gctggttggg ggagcccgaa gattttcagg accccaagta cgacgtgatc ggcgcacgtt
2113921 tggccgcatg gccgcagatc agcgtgttgg tcgcgaagtt gtgcgccgag aagaccatga
2113981 aggagttggt ggcagccggc caagcgctcg gggttcccat taccgcggtg ctgacaccgt
2114041 cgagaatcct ggcctccgaa cacttccagg cggtgggtgc gatcaccgat gccgagctcg
2114101 ttccgggggt gcgcaccggg gtgcctaccg gatacttcgt tgtcgacggg aagcgcgccg
2114161 gtttccgtac tccggccccc gccgcggggc aggacgaacc gcgctggctc gcggatccag
2114221 cgccggtgcc cccaccctca ggccgggtcg gcggctatcc attcgaaggt ctgcggattc
2114281 ttgatctggg catcatcgtg gccggcggcg agctcagccg gctgttcggc gacttgggcg
2114341 ccgaggtcat caaggtcgaa agtgccgacc accccgacgg gttgcggcag acccgagtcg
2114401 gggatgcgat gagtgaatca ttcgcgtgga cccatcgcaa tcacctcgcg ctgggcctgg
2114461 acctgcgcaa cagcgagggc aaagcgatct tcggtcgcct ggtcgctgaa tccgacgcgg
2114521 tgttcgccaa cttcaaaccg ggaaccctta cctcacttgg gttttcctac gatgtactgc
2114581 acgccttcaa cccccggatc gtgctcgccg ggagtagtgc attcgggaac cgagggccgt
2114641 ggagcacccg gatgggctac gggccactgg tgcgcgccgc caccggggtc acccgtgttt
2114701 ggacatccga tgaggcgcag ccggacaact ctcggcatcc cttctacgac gcgacgacga
2114761 tcttccccga ccacgttgtc gggcgggtcg gtgccctgct cgcgctggcg gccctgatcc
2114821 accgcgatcg aactggcggc ggagcccacg tccacatctc ccaggccgaa gtcgtcgtca
2114881 atcagctaga caccatgttc gttgccgagg ccgcccgagc gaccgacgtt gccgagatcc
2114941 acccggacac cagtgtgcat gcggtctacc cttgtgctgg cgacgacgaa tggtgcgtca
2115001 tctcaatccg ctccgacgat gaatggcgtc gcgcgacatc tgttttcggc cagcctgaat
2115061 tggcgaacga cccacgcttc ggggcaagcc ggtcacgcgt ggccaaccgt tcggagttgg
2115121 tggccgcagt gtcggcctgg accagcaccc gtaccccggt gcaagcggcc ggcgcgctgc
2115181 aggcggccgg agttgcggcc ggcccgatga atcgcccgtc ggatatcctc gaggatcccc
2115241 agctgatcga gcgaaacctg ttccgcgaca tggtgcatcc gctgatcgcc cgtccgctgc
2115301 ccgccgagac gggtccggct ccgtttcgtc acattccgca ggcaccccaa cgcccggcgc
2115361 cgctgcccgg acaggacagc gttcagatct gccgcaagct gctcggcatg accgcggacg
2115421 agaccgaacg cctaatcaac gagcgcgtaa tgttcgggcc ggccgtcact gcctaagtgg
2115481 tctcgccggt gtcgttcgtc gacggtcggc tgattgccct tccggctccg agatcgacgt
2115541 tttgcccgcc tgttcgtgct ttatctgcga agccccgatc tgggcgcatc ggggtgacgc
2115601 attcgggcag ctaaagcttt tcgacccgca agccggcggt gcccctcctc gttccgctgc
2115661 ccggtctgct cgatcggttc ggggtcgccg cgctaggccc aattgcccgg ctcctcctcg
2115721 ggccgttcca cgacccgcat cgtcgccggg ctaggttcaa gccatgccgg tagaccccag
2115781 gacgccagtg ctgatcggct atggacaggt caaccaccga ggcgacatcg acgccgagaa
2115841 gcagtccatc gaacccgtcg acctgatggc cgccgcggcc cggaaagccg cggattcgac
2115901 ggtgctcgag gcggtggatt cgatccgtgt ggtgcacatg ctgtcggcgc attaccggaa
2115961 tcccgggcag ctcctcggcg aacgaatcaa ggcgaggacc ttcaccaccg gttacagcgg
2116021 ggtgggcggc aacatgccgc aatccctggt caaccgggca tgcctggaca tccagcgcgg
2116081 gcgggccggc gtggtgctgc tggctggcgc cgaaacctgg cgcacccgaa cgggcctgcg
2116141 cgccaagggc agcaaactgg agtggactgt gcaggacgaa tccgttccgc tgccggacat
2116201 ggccggcgac gacgttccga tggccggtgc ggctgagctg cggatcaacc tggaccggcc
2116261 ggcctacgtg tacccgatat tcgagcaggc gctgcgcatc gcctacggcg agtcgatcga
2116321 gaaccaccga aagcggatcg gcgagctgtg ggcgcggttc agtgccgtag ctgctgacaa
2116381 cccgcacgcg tggatccgca acccggttac ggctgacgag atctggcagc ccggcccaca
2116441 gaaccggatg gtcagctggc cctacaccaa gcttatgaac tccaacaaca tggttgacca
2116501 gggtgccgcg ctgctgctga cgtcggtcga acgtgcgaca cgtctgcgaa taccggccga
2116561 acgctgggtt tatccacagg ctggcaccga cgcccacgac acaccggccg tcgccgaccg
2116621 ccaccgactg catcggtcga cggccattcg gatcgccggt gcccgggcgc tggaactggc
2116681 tgggctgggg ctcgatgaca tcgaatacgt cgacctgtat tcgtgctttc cctccgctgt
2116741 ccaagtcgcc gcaatcgaac tcggcctgga caccgacgat cctgcccgcc cgctgaccgt
2116801 caccgggggc ctgaccttcg ccggcgggcc gtggagcaat tacgtcacgc actccatcgc
2116861 caccatggct gaactgctgg cggccaatcc cgggcgccga ggcctgatca ccgccaacgg
2116921 cggttacctg accaaacaca gtttcggggt ctacggcacc gagccgccgt cggaattccg
2116981 ctgggaggac atgcaacccg cggtcgatag ggagcccacc ggagatgggt tggtcgagtg
2117041 ggaaggcatc ggcaccgtcg aagcgtggac cacaccagtc aaccgggacg gacaacccga
2117101 gaaggcgttc ctggcggtgc gcacgcccga cgggtcgcgc agcttggccg tgatcaccga
2117161 tcccgcatcg gtgcaagcaa cggtgcgcga ggacatcgcc ggcgtcaagg ttgccgtcgc
2117221 ccccgacggc accgcgaccc tgcgatagcc ggcgggcagc acgagtcacg ttccagaagc
2117281 aatggtcgcg caagcgacac tgacgtgcct attgtcatga ggagacgttg ggggaggtga
2117341 ggccgggtgc agatcctggt taccgacgcc acgggtgccg tcgggcggtc ggtcactcgg
2117401 cagttgatcg ctgccggaca cacggtgagc ggtatagccc agcacccgca cgatgctctg
2117461 gacccccgcg tcgactatgt ttgcgcgtcg ttgcgcaacc cagtgctgca agagttagcc
2117521 ggcgaagccg acgcggtgat ccatctcgcc ccggtcgaca ccagcgcccc gggcggtgtt
2117581 ggcatcaccg gactggcaca tgtggccaac gcggccgccc gcgccggtgc ccggctgctg
2117641 ttcgtttctc aggccgctgg gcgacccgaa ctatatcggc aggctgagac gctggtgtcc
2117701 accggttggg cacccagctt ggtcatccgt attgcgccac cggtcggccg ccaactcgat
2117761 tggatggtgt gccggacagt ggccacgctg ctgcggagca aagtctcggc acggccgata
2117821 cgagtgctac atctcgacga cttggtccgc ttcctggttt tggcgctgaa taccgaccgc
2117881 aacggtgtcg ttgacctggc cacccctgac accaccaatg tggtcaccgc gtggcggctg
2117941 ctccgatccg tggacccgca cttgcgaaca cgtcgggtcc gcagctggga gcaattgatt
2118001 cccgaggtgg atatcgctgc cgtgcaggag gattggaact tcgagttcgg ctggcaagcg
2118061 accgaagcaa ttgtcgacac cgggcggggc ctcgtcggcc gcagactgca cccggcaggc
2118121 gcgaccaacg gatcgggtca actagcactg ccggtggagg cgcccccgcg gtctgtgcct
2118181 tcccacgggg aacccttggg cagcgcggct ccagaagggt tggagggaga gttcgacgac
2118241 cgtatcgacg agcggttccc ggtcttcagc tcggccagtc tcgccgaagc gctgccgggt
2118301 ccgctgaccc cgatgacgct ggatgtccag ttgagtggac tgcgcgcggc cggtcgggcg
2118361 atgggtcggg tactggcgct tggcggtgtc gttgccgatg agtgggagag aagagccatc
2118421 gcggtgttcg gtcaccgccc gtatatcgga gtgtcggcca atattgtggc cgccgcccaa
2118481 ctgccggggt gggacgcgca ggccgtagcc cggcgggcac tgggcgagca accgcaggtc
2118541 actgagctgc ttccgtttgg tcgaccgcaa cttgcgggcg gaccgctcgg ctcggtcgcg
2118601 aaggtggtcg tgacggcgcg gtcgctggcc ctgctgcgcc atctccggag cgacacacac
2118661 cactatgttg ccgccgcaga tgccgagcac ctcgctgccg ggcagcttgc ctcgctaccg
2118721 gacgccggct tggaggtccg gattcggctg ttgcgtgatc gcatccacca aggctggatt
2118781 cttacggtgc tgtgggtgat cgacacgggc gtcacagcgg cgacgttaga gcacacccgc
2118841 gcaggctccg cggtgtccgg agggggcatg atcatggaaa gtggcagaat cggcgccgag
2118901 attgctccgc tggctgcggt gctgcgcgcc gacccgccgc tgtgcgcgct ggccaacgac
2118961 ggcaacctcg ccagcatccg cgcgctgtct gctcccgccg ccgccgcagt tgacgcggtc
2119021 attgcccgga tagggcaccg cgggttaggc gaagccgagc tggctaacct gacgtttgcc
2119081 gacgatccgg cgctactgct gaagacagcc gccgaaatcg ccgcgcggcc cgccgggcca
2119141 gctcacccag cgacgttgat ccagcgactg gctgccggca cgcgcagtgc ccgggagctg
2119201 gcgcacgaca ccaccatccg attcacccat gagctccgga tgacattgcg ggagttggga
2119261 tctcgacgag tcgcggcgga tgtgatagac gtcgttgacg acgtgttcta cctgacctgc
2119321 gacgaactga ttaccacgcc ggccgacgct cggctgcgaa tcaaacgtcg gcgcgccgaa
2119381 cgagaacgcc tgcaggcaca gcgcccgcca gacgttatcg atcatgcctg ggtacccgtg
2119441 gagtagcggt caacacacgt caattcgtcg tcaggtccgc caacggccac tgcggatcaa
2119501 ccagcctgtc aacgtcgacc gggttcccgg accggatcag gcccttgacg tcgtccacca
2119561 cgtcccagac gttgacattc atcccggcta gcacccggct gtcgccgtcg agccagaagg
2119621 agaggaactc gcggccggca acgttgccac ggaacaccac ccgatcacag ctgggggcgt
2119681 ggccgacgta ctccatgccg aggtcgtatt gatcggtgaa caaatagggc agttcagcgt
2119741 attcgcccgg ccggcccagc atgccggcag ccgccaccgc gggttgtttg agcgcgttgg
2119801 cccagtgttc ggtacggacg cgggtaccca atagcgggtg ttcagcggcg gcaatgtcgc
2119861 cgactgcgta gatgtcggga tcgctggtgc gcagcgatgc atcaaccaac acaccgccct
2119921 cgcccatcgc cagcccggcc tgttgggcga gttctacgtt gggcttcgcg cccacagcga
2119981 ctagcacggc gtcggcggca accgtcgacc cgtcacgcat cttgagcccg gtcgccttgc
2120041 cgtcggctgc agtgatctct tcgagctggg tctgcaaccg taagtccacc ccttgatctc
2120101 gatgtaggtc ggcaaacact ttgccaaccg cttccccgag cgcggccagc agcggttgta
2120161 tggcggtctc gacgacggtg acgtcgacgc cacgttgacg cgcactggcg gccacttcca
2120221 ggcctatcca gccggcaccc accactgcga gggaagaccc ctgcaccaga acggagttca
2120281 atgccacggc gtcgttgtag ctgcgcaggt agtggacgcc ggcggcatcg gatccaggta
2120341 ttggtgggcg ccgtggggcc gatcccgtgg ccaacagcag cttgtcgtag cgcaccgcag
2120401 cgccgtcggg aagctctacc gtgtgtgcgg accgatccaa tgacgacacc cgcacgccga
2120461 gccgcacatc cacgtcatgg tcgcggtacc aatcggaggt ctggatggtg aagtcgctca
2120521 gcgacttttt gccggccaga aactccttgg aaagcggcgg ccggtcgtag ggcaggtgct
2120581 cttcgtcgcc gaacaagata atccgaccgc cgaagtcgct gcggcgcaac gcctctacgg
2120641 ctttagcccc ggcaagtccc ccgccaacaa tgacgaacgt ggttgagctg gccataattg
2120701 ctgctccgtc ctgttgtgtg cggtgccgct tgacagccta cgagccggtc gcgtacctgg
2120761 gtcaaccggt cacctgcagg cgcagctcgt cgtcttacgc cactcgcact aacgcagcag
2120821 cgagcagcgc attggagctg ggtgccaccg acgccagctt cttcgggtca gtgggcaagc
2120881 cgagctgctt cgccgcggcg gtggctcgat cgtcgaaata cggtcgtacc cagatccaga
2120941 cgtcttggac ctcgcgtaag aaaatgtcgg caccggtgtc gccgattccg ttgaaagtct
2121001 tgagcatacg tttggcggcc gaaacgtcgg gtcgtgtgcg ctgggcgagt tcccgcaaat
2121061 caccggagta ctcgtcgcga acccggtgag cgatagcggt gagccgggtg gctgagctct
2121121 cgtcataccg cacgtagtgg gcacggccaa acgcactgat catcgtttgt cgctctgctg
2121181 acagcacagc tttgggtgtc cgcaggcccg agcagaacaa ttcccgggcg gcacgtgctg
2121241 ccgtggcggc accgatcggc ttgctggcca gcatgcacag caccagcagc tgaaacagcg
2121301 gcatcggttt gtccctgatc cggattcccg cctccgccgc gtaagtggtg ccggcgagtt
2121361 taagcagtcg tcgtgccagt ggctccggct tgatcacaag caaccgcata cccgcaatgc
2121421 gtggcggcaa accgcgacta ttgctcgggc aagcgcgctc cggcggccta agccccggtt
2121481 ccggccaacc cctgtcagtc caaatccacc cggatggtca gcaagtcggt gcccatcgcg
2121541 cgtacgccgg cactgttcag ccggggtagg ccgcgcagcc gctgcctcgg atcgtcgtcg
2121601 ggtagcaggt aggcggtccc actgcgccat cggccgccga tgcggacccg cacggcgggg
2121661 ttggccttga tgttgtagac gtaatcggaa tgctcgccgt gctcggacac catccagaac
2121721 tggttgtcta cgacgcgccc gcccaccgcg gtacgccgcg gctgtcccgt tttgcggccg
2121781 atggtttcga gcatggtcat cggcagttgc cggccgattg gattgaccac gaaccgttgc
2121841 acgcgatgga cgaattcccg cttgagattc atagctgcat tcaacgctac cgatctggcc
2121901 gcggcctcac gttggtgccc cgatagggcc gagccgccgc agttgtgtca cgtgccgagg
2121961 tgacagctcc tcaaggcagg tcacgcccag tagccgcatg gtccggatca cacctgtctg
2122021 aaggatctcg atcgcgcggt tgacgcccgc ctcaccaccg gccatcagcc cgtaaaggta
2122081 ggcccgcccg atcagcgtgc accgtgcccc caacgcgatc gccgcgacga tatcggcgcc
2122141 cgacatgatg ccggtgtcca ccaggatttc ggtgtgtttg cccagttcgc gtgccacgtg
2122201 gggcaacagg tggaagggta ccggggctcg gtcaagctgg cggccgccgt gattggacaa
2122261 cacgatgccg tcgacgccgc ggtccaccac ggcgcgggcg tcgtcgagtg tttggatccc
2122321 tttgacaacg agcttgcccg gccactgcga cttgatccag gccaaatcgt cgaaggtgag
2122381 gctggggtcg aacacggtgt tcaagtactc gccgacggtg ccaggccagc gatccagtga
2122441 agcgaaggcc agcggttcgg tggtcaacaa gtcgaaccac caccgcgggt gtcccatcgc
2122501 gtcgagaacg gttcgcagcg tcagcgccgg cgggatggac atcccgttgc ggacatcgcg
2122561 tagccgggca ccggcgaccg ggacgtcgac cgtgaccagc atggtgtcaa atcccgcggc
2122621 ggcgacgcgc cgcaccaatg ccatcgagcg gtctcgatca cgccacatat acagctggaa
2122681 ccatttgcgg ccctgcggca cagcgatgac gaggtcttcg atggcacagg tggccagggt
2122741 ggatagcgaa aacgggatcc cagccgcggc cgccgcccgc gcgccggcga tctcgccctc
2122801 ggtgtgcatc aagcgggtga acccggttgg cgcgatcccg aatggcaaga cggtgggctg
2122861 accgaggacg ttccagccgg cgcacacggt ggtgacgtca cgcaggattg tcgggtgaaa
2122921 ctcgatgtcg cggaaccctt gtcgagcacg cgcgatggac agttcgtcct cggcaccccc
2122981 gtcggcgtag tcgaacgccg ccctaggggt acgccgtttg gcaatgcgtc gcaggtcctg
2123041 gatggtcagc gcggcgccca ggcggcgctt ggaggtgtcg aactgcggcc tgttgaactg
2123101 gagcaggggt gccagatcgc gcactctggg cactcgccgg ttgaccgcca tccgtttatc
2123161 taaccagttt gatatgaagt cagcaagcga cccgttcgac ctgaagcgtt tcgtgtacgc
2123221 gcaggctccg gtctaccgca gcgtcgtcga ggagctgcgc gccggacgaa agcgcggtca
2123281 ttggatgtgg ttcgtcttcc cacaactccg cgggctaggt agtagcccac tggcagtgcg
2123341 ctacggcatc tcctcgctcg aggaagccca ggcctatctg cagcatgacc tgctcgggcc
2123401 ccgcttgcat gagtgcaccg ggttggtcaa ccaggtgcaa ggccgctcaa tcgaggaaat
2123461 cttcggcccg cccgacgacc tcaagctgtg ctcgtcgatg accctgttcg cccgtgccac
2123521 cgacgccaac caggactttg tcgcgctgct cgccaagtat tacggcggcg gagaggaccg
2123581 gcggacggtg gcattactgg cggtcacata gaccgcgcga tccaccgggg cgtcgacgcc
2123641 tgacagcgga tgtaggttcg ggctcatgga gaaggtgatc gccgtgctca tgcggcccga
2123701 gccagacgac gactggtgtg cccgccaacg agctcaagtc gccgacgccc tgctgggact
2123761 gggcgttgct gggctgtcga tcaatgtccg ggacagtacc gtgcgcgact cactgatgac
2123821 cctgacaacg ctgtacccac cggtcgcagc ggtggtcagc ctgtggaccc agcagtgcta
2123881 tggcgagcag gtagcagccg ccctcaggct actggctcag gagtgtgatg aactcggcgc
2123941 atacctggtg accgagtcgg ttccgctgac cttcccatcg ctcgtcgagt ccggttctcg
2124001 tacaccgggt ctggccaaca tcgcgctcct gcgccggccc gatggcctgg accaggcgac
2124061 ctggctgacc cgctggcagc gcgaccacac gcaagtggct atcgaggcac aggcgacatt
2124121 cggctacacc cagaactggg tggtacgagc cctcacccca gaggcaccgg gaatcgcggg
2124181 cattgtcgaa gagttgtttc ccgtggcggc gacaaccgat ctgaaagcct tcttcggagc
2124241 cgccgacgac aacgatctgc ggaatcggat aagccggatg gtcgcgagca catctgcatt
2124301 cggtgccaac cagaacatcg acaccgtgcc aaccagccgc tacgtgttca gaacaccgtt
2124361 caaggattga ggaacgtgag atgacaacac tcaacgaagc cgcggcactg gcggcggcag
2124421 aacgtgggct tgcggtggtt tccaccgttc gtgccgacgg caccgtgcag gcgtcgctgg
2124481 tcaacgttgg actgttgccg catcctgtca gcggcgaacc atctctggga ttcaccacct
2124541 atggcaaggt caaactcggc aaccttaggg cgcgcccaca actggccgtc acgttccgca
2124601 acggttggca gtgggcgacc gtcgaaggcc gagcacaact tgtcggcccc gacgatccgc
2124661 ggccgtggct ggtcgacggc gagcgattgc ggctgctact ccgcgaggtc ttcactgcgg
2124721 cgggtggcac gcacgacgac tgggacgagt acgaccgggt gatggcgcag gagcagcgcg
2124781 ccgtggtgct gatcacgccc acccgcatct acagcaacgg ctgagggact cagcaaacgg
2124841 cgtcgctcgt gcgacctgcg gggtcgagtt gggttgggtt gagtcgggcg gctgcgatga
2124901 tagctcgcag tgtgcgccgg cagcgtccgc agtcgccgcc agccccgcac acagcggcca
2124961 cttctttgga ggtcgacgca cctcgcgcca cggcgtcaca cacggtttgg ttggtgacgc
2125021 cgacgcacaa gcacacgtac atcagcaaac ccccagcaga tgctgcgtcg gcgaacgatc
2125081 aagccgcata ttagtggagt ctagcctaag ctgattagtg gagtctaacc taacaatgac
2125141 ccgcggcttg gactttgcgc cggcgagacg cgccgacgcc gcaacaaacc ctgcgccgac
2125201 ccgtactcgc tgcactagat tgagacgcgg cacgcaaacg tgctgttatc agcccaagac
2125261 gagcccgaca ccggtgcgct ccagccctgc ccacctggcg cggttcgcca cgacagcctt
2125321 atatcccata ggagtggtca tgcaaggtga tcccgatgtt ctgcgcctgc tcaacgaaca
2125381 attgaccagc gagctcaccg ctatcaacca atactttctg cactccaaga tgcaggacaa
2125441 ctggggtttt accgagctgg cggcccacac ccgcgcggag tcgttcgacg aaatgcggca
2125501 cgccgaggaa atcaccgatc gcatcttgtt gctggatggt ttgccgaact accagcgcat
2125561 cggttcgttg cgtatcggcc agacgctccg cgagcaattt gaggccgatc tggcgatcga
2125621 atacgacgtg ttgaatcgtc tcaagccagg aatcgtcatg tgccgggaga aacaggacac
2125681 caccagcgcc gtactgctgg agaaaatcgt tgccgacgag gaagaacaca tcgactactt
2125741 ggaaacgcag ctggagctga tggacaagct aggagaggag ctttactcgg cgcagtgcgt
2125801 ctctcgccca ccgacctgat gcccgcttga ggattctccg ataccactcc gggcgccgct
2125861 gacaagctct agcatcgact cgaacagcga tgggagggcg gatatggcgg gccccacagc
2125921 accgaccact gcccccaccg caatccgagc cggtggcccg ctgctcagtc cggtgcgacg
2125981 caacattatt ttcaccgcac ttgtgttcgg ggtgctggtc gctgcgaccg gccaaaccat
2126041 cgttgtgccc gcattgccga cgatcgtcgc cgagctgggc agcaccgttg accagtcgtg
2126101 ggcggtcacc agctatctgc tggggggaac tgtcgtggtt gtggtggctg gcaagctcgg
2126161 tgatctgctc ggccgcaaca gggtgctgct aggctccgtc gtggtcttcg tcgttggctc
2126221 tgtgctgtgc gggttatcgc agacgatgac catgctggcg atctctcgcg cactgcaggg
2126281 cgtcggtgcc ggtgcgattt ccgtcaccgc ctacgcgctg gccgctgagg tggtcccact
2126341 gcgggaccgt ggccgctacc agggcgtctt aggtgcggtg ttcggtgtca acacggtcac
2126401 cggtccgctg ctggggggct ggctcaccga ctatctgagc tggcggtggg cgttttggat
2126461 caacgtgccg gtttcgatcg cggtgctgac agtggcggca accgccgtcc ctgcgttggc
2126521 ccgaccgccc aaaccggtca tcgactacct tgggatcctg gtcatcgctg tggccacgac
2126581 cgctttgatc atggccacaa gttggggcgg aaccacctac gcctggggct cagcgaccat
2126641 tgtcgggctg ttgatcgggg ccgcagtggc gctgggtttc ttcgtgtggc tggagggccg
2126701 cgccgctgcg gccatcctgc cgcccaggct gtttggcagc ccagtatttg ccgtgtgctg
2126761 cgtcctgtcc ttcgtggtcg gattcgcgat gctgggtgca ctgaccttcg taccgatcta
2126821 tctggggtac gtggacggcg cgtcggcgac cgcgtcaggt ctgcgcacgt tgccgatggt
2126881 gatcggcctg ctgatcgcct cgaccgggac gggtgtcctg gtcggccgga cgggccgcta
2126941 caagatcttc ccggtcgcgg ggatggcgct gatggcggtt gcgttcctgc tgatgtcgca
2127001 gatggacgag tggacgccac cgctgctgca atcgctgtac ctggtcgtcc taggtgccgg
2127061 catcggattg tccatgcagg tgctcgttct catcgtgcag aacacgtcgt ctttcgaaga
2127121 cctcggcgtc gcaacatcgg gtgtgacctt cttccgggtg gtcggcgcct cgtttggtac
2127181 cgcaacattc ggtgcgttgt tcgtaaactt cctggaccga agactcggtt ccgcgctgac
2127241 gtcgggcgcc gtgcctgtcc cggcagtgcc atctccggct gtcttgcatc agctgcccca
2127301 gagcatggcc gccccgatcg tgcgggcata tgccgagtcg ctcacccagg tgttcctttg
2127361 cgcggtctcg gtcacggtgg tcggtttcat cctggcgctg ttgctgcgag aggtaccgct
2127421 caccgacatc cacgatgacg ccgacgacct cggcgacggg ttcggtgtgc ccagagccga
2127481 atcgccggag gatgtgttgg aaatcgcggt tcggcgtatg ctgccgaacg gggtgcgact
2127541 gcgcgatatt gcgacacaac ccggttgcgg actcggcgtc gccgagctgt gggcccttct
2127601 gcggatctat caataccagc ggctgttcga ggcagtacgg ctgaccgata tcggtagaca
2127661 cctgcacgtg ccctatcagg tctttgaacc cgtcttcgac cgtctggtcc agaccggcta
2127721 cgcggcacgc gacggcgaca tcttgacgct aaccccgtcc gggcaccgtc aggtcgactc
2127781 cctcgcagtt ttgatccgtc agtggctgct cgaccacttg gccgtggcgc ccggcttgaa
2127841 gcgacagcca gaccaccaat tcgaagccgc tctgcagcac gtcaccgacg cggtgctcgt
2127901 tcaacgagac tggtatgaag atctgggcga cctgtcggaa tcacgccaac tcgcggctac
2127961 aacgtagcga tgcttgccgc gcgtagccgc gcgagctgat ccgcgctgca gaatgactgc
2128021 catgacagcc acaccgcttg ccgcggccgc gatcgcccaa ttggaggcag agggcgtcga
2128081 caccgtcatc ggcaccgtcg tgaaccccgc cggactcacc caggccaaga ccgtgccgat
2128141 acgccggacc aacacattcg ccaatcctgg cctcggcgcc agtccggtgt ggcatacctt
2128201 ctgtatcgac caatgcagta ttgcattcac cgcagacatc agtgtggtcg gcgatcaacg
2128261 tctccgcatc gatctgtccg ccttgcgcat catcggcgac gggttggcgt gggcgcccgc
2128321 cgggttcttc gagcaggacg gcacaccggt ccccgcctgc agccgaggaa cactgagccg
2128381 gatcgaggcc gcgcttgctg atgccggcat cgacgcggta atcggccacg aagtcgaatt
2128441 cctcttggtc gacgcggacg gccagcggct gccttcgacg ctgtgggcgc agtacggtgt
2128501 cgccggggtg ctcgagcacg aggcgttcgt ccgcgatgtc aacgccgcgg caacggcagc
2128561 aggcatcgct atcgagcagt tccatcccga atacggtgcc aaccaattcg agatctcgtt
2128621 agcgccgcag ccgccggtcg cggccgccga tcagctggtg ctgacccgcc tcatcatcgg
2128681 ccgtaccgcc cgccggcacg ggttacgcgt gagcctatcg ccagcgccct tcgccggaag
2128741 tatcggatcc ggtgcccacc aacacttctc gctgactatg tcggaaggga tgctgttctc
2128801 cggtgggact ggagcagctg gcatgacctc ggccggggag gccgcggtgg caggagtgct
2128861 tcgcggacta ccggacgccc aaggcatcct gtgcggatcg atcgtgtccg gtctgcgaat
2128921 gcgacccggt aactgggccg gaatctatgc atgctggggt accgaaaacc gggaagcggc
2128981 ggtgcgattc gtcaagggcg gggctggcag cgcgtacggc gggaacgtgg aggtgaaggt
2129041 cgtcgacccg tcggccaacc cgtatctcgc gtcggcggcg atcctcggac tggcactcga
2129101 cggcatgaag accaaggcgg tgttgccgtc ggaaacgacc gtagacccga cacagctgtc
2129161 tgacgtggat cgtgaccgtg ccggcattct gcgacttgct gccgatcagg cggatgcaat
2129221 tgctgtactg gatagttcga aactgcttcg gtgcatcctt ggcgatcccg tggtagatgc
2129281 cgtggtcgcg gtacgccagt tagagcatga gcgctacggt gacctcgatc ctgcgcagct
2129341 ggccgacaag ttccggatgg cttggagtgt gtaacgatgg ccgactccgc cggttcggac
2129401 ctgacgcggc acacggccga agtgccgttg atcgatcagc acgtccacgg atgctggctg
2129461 accgagggga accggcggcg gttcgagaac gcgctcaatg aggccaacac cgaacccctg
2129521 gcagacttcg actcgggatt cgactcacaa ctcgggttcg ccgtgcgcaa ccactgcgct
2129581 cccatccttg gattgcctag gcacgttgat ccgcagactt attgggatcg ccgcagtcaa
2129641 ttcagtgaag ctgaattggc tcgcagattt ctgcaggccg ccggggtaac cgactggctg
2129701 gtggagaccg gaatcggcta cgacgtgtcc ggaatggcaa gcgtcgccgg cctcggcgaa
2129761 ctgtcgggca gccacgctca cgaggtggtt cgtcttgaac aggtggccga acaggccgtg
2129821 caggcatccg gcgactacgc ctcggcgttc aacgagatac tgcgccggcg cgcagccaca
2129881 gcggtggcaa ccaagtccat cctggcctat cgaggtggat tcgacggtga tctgaccgag
2129941 ccacccgcgg cgcaggtcgc cgaggccgcc aagcgctggc gcgaccgtgg cggtgtccga
2130001 ttacaggatc gggttctgct gcgcttcggg ttgcatcagg cgttgcgcct gggcaagccg
2130061 ctgcagttcc acgtcggatt tggcgaccgg gacgctgatc tgcacaaggc caatccgctg
2130121 tatctgctcg acttcctgcg gcagtccggc aataccccaa tcgtgttgct gcactgctat
2130181 ccctacgaac gagaagccgg ttatctggca caagccttca acaacgtcta tcttgacggc
2130241 gggttgagtg tgcactacct gggggcccgg tcgccggcct tcatcggccg actactggag
2130301 cttgccccct tccgcaagat cgtgtactcg tcggacggat tcggccccgc ggaactgcac
2130361 tttctcggtg caacgttgtg gcgcagtgga attcagcgtg ttctgcgtgg ctttgtcgag
2130421 cgcgacgact ggtgcgagac cgatgccctg cgggtggtcg acctaattgc ccatggcact
2130481 gccgcacgca tctatcgcct tggcgatcgg tagctttcag gtggcgcaag tgtggccccg
2130541 tcacgggcta accatggacc gtgccggacc cagtgtcacc ggcagcgtcg accaaccgcg
2130601 cagcacccgc gtgtcacgcc gacttccggc acccgcggcc cgcacatcgg ggaagcggtc
2130661 gaagaacgtt ctcagcccga cctcgccttc ggcgcgggcc agggcggccc ccaggcagaa
2130721 gtggcggccg gtagagaacg caagatgtcg tccggcattg gggcgttcga tgtcaaagcg
2130781 gtgcggatcc gggaacacag cgggatcgcg gttggcggct gctaggtaga tcaccacgac
2130841 ttcgccgcgt ttgattcgca caccagccac ctcgacgtca cggcaagcca cccgggcggt
2130901 gagctgaacc ggcgaatcca gccgcaggat ttcttcaacc gtattcggcc acagctccgg
2130961 atgttggcgc agtgtggcca gatgttcggg ggtatccaac aacatgcgaa tcccgttgcc
2131021 taacaggttc actgtggttt cgaatccggc gaccaaaacc agtccggcga tcgcccgaag
2131081 ttcggtctcg tcgagctgtg tctcgttgtc cccgctttcg gcgatctgga tcaactgact
2131141 catcaggtcg tcacccggag cgtgccgcaa ctgctgcaga tgcccttcca gccagcagtc
2131201 gaatcctcgt atcccctgct gcacacgcag gtactgccgc cacggaatcc cgatgtctag
2131261 actcggcgct gccaactcac caaattccag gacgcgcggc ctgtcatgct cgggcacgcc
2131321 caaaatttcg ctgatgacca cgatcggcag ttgcgagcaa tagcgtccta cgacgtccac
2131381 aatcccgggc tgctcagcga accgatccaa gagattgatc gcggtctgtt cgaccagatc
2131441 gcgtagcgcg ctgaccgccc gtgaggtgaa caccgccgac accgttttgc ggtagcgagt
2131501 gtgatcgggc ggctcgacgg ccagcagcga aggttctcgc agggggtgaa gttgatcgcc
2131561 gcgggtccgc cgctccagcc agcgcagcgg tggtggcaga ttctcgccga aggagacgac
2131621 gcggaagtcg tccgatcgca gcaggtcatg ggcgagccga tggtcgacgg tcaggtagtt
2131681 ggcgcggttg cgcaccaggg cgccgtggga ccggacttcg tcgtaaaagg gcaccggatc
2131741 ggtggcgacg gccggatccg cgatcagccg ggcctgcaag tcgccacgcc gaatcccgat
2131801 tgccgcaatg ccgcggatca ccccgtgcat cgccaaccag tgcagcttgt ccttcaccgc
2131861 gcctccgtcg atcgagtggc ttttcttcaa gactagaacc cgcaattcaa cattcggcga
2131921 ggatgttgaa gtctgttgac accaccgtgt tgggtttttt gctgctgatg ccgtaggcac
2131981 tgccggcaac tgtgtatgtg ttgcgggcgc ggtcggcgcg ggcgttgccc accccgccgt
2132041 gccagaagct gccgttgaac ccgtcgacgt tacggatctt cacccactgc gggattaccc
2132101 tgtcaccgct gagcaatacc acggcttgga cggtgctgtc gtggttgcgg atgtcgatgg
2132161 tccggtagga gtgctcctgg ctgcatgttg cgggacgtgt cgtgtgagtg acgccgtcaa
2132221 tagtcaggcg tgcggctttt cggggtaccg tctgagcttg cccgcacgcg gagagaccag
2132281 ccgcgacgac cattgcaact ccggtcactg tgaccaaccg attgcacacc agccacctcc
2132341 attcgggcct gagcattgtg ctcgggacat tacttccgtt ttggctccaa cgtggccagg
2132401 gacttggcaa tgtgacgtcg gacgaactcc ggactgacgc ccttgagccg atcaatccag
2132461 cgaatgcttc ggggcacata ccaatgcaac cgtgtggggt gctggtaggc ccgccaggct
2132521 gcctcggcga cgctggacga gggcatcagc cggaacatgc ccttcttggg cgcggcagcg
2132581 cggatctgct ccgcggagat cgtgtagggg ccctcgtcgg aatgctggcg cgtcgaggtg
2132641 aggatagcgg tgtcgatcag accgggcagc acgtcggcga cgcgaacccc atgacgctgc
2132701 cactcaacgc tcaacgcctc ggtcaacccc ttgacggcgt gtttggtcgc cgagtagacc
2132761 gcgatacgcg gcatgccata ggtgcccgag gacgacgacg tcgagaacat cagacttccc
2132821 ggtgctttct tgaggtaagg cagtgcggcg taggcgccag tgagcaccgc cttgaagttc
2132881 acgtcgacga cgcgcacggc ggcctcgtac ggcacgtcct cgaaccaacc gccttcgccg
2132941 atgccggcgt tgttccacat catgtcgaga ccgccgccga cattgccggc gcagaaatca
2133001 gcgagcgcac cctcaagggc cgccttgtcc gtaacgtcga cggcgcgggc ccacagccgt
2133061 tcggcaccaa gctgtacgcg cagggcagcc agcccatcct cattgcggtc tatcgcacct
2133121 actcgccagc cgttggcgtg gaaaagcgtt gcaccctcgc ggcccattcc actgccggcg
2133181 ccggtgatga atatcgcttt catgcggaat ccggaatagc cgaaccgccc tcagcctgct
2133241 tcaaccagat ctttgatgcg ctgcaacgtc ttggtcatgt ctcggatgtt gcggcgctga
2133301 cgcagccagc ccccgaacac ccggtagtac acggtggtca acacggacgg ggggagccga
2133361 aacgactcag tgacctcggt gccgtcggcg gtgggcgtca aacgataatg ccaattgttc
2133421 accggtctgt cgccgagcag cacagcaaac ccgaactcac ggcccggttc gcataccgtc
2133481 cagtagaccg gcccgatccc gttgcgccgg acatgcccgc ggaatcgagc gccaagcgcg
2133541 gggccggtgg caccgtcaag ccactcggcc tcgaaggttt ccggcgagaa ccggccggta
2133601 ttgcggacat ccgcgatcaa tgtccagatc ttgtccggcg gcgctgccat gtgaactgtg
2133661 gccgaacctt ccatgacctg atccaaacac atacgtcgac ctggtcatag accgcacacg
2133721 ccgccaaccg tcagcgcgga atacttgcct gaatgcctgc ccaaatgatc tcgttgatga
2133781 tttgcttgat gccctgcgcg ggtttcgacc acagtgcgat cggaaggcca gaggcggcgc
2133841 cgcacgtcgg ccacgcgtcc aatccctgtt cggcgagaac ccgattggca actgcgattt
2133901 gttgttcccg agaggcagct gctgggttgc cgacaccgcc gaatgcggcc caggtggccg
2133961 gcttgaactg cagtccgccg tatttgccgt ttccggtgtt ggccgcccag ttgcccccgg
2134021 attcgcactg cgcgacggcg tcccagttcg ggctgggacc ggcgtgggca acggcggtgg
2134081 agagcgacat ggatgccgtg acgagtcctg cggccatggc ggacttgatg agcggcttgg
2134141 cgattcttgt catgctcgac atatcgccgg aagtggccga agcgttaccg attagagaga
2134201 gtggtgagat cgggtgtcta ttgcaccgcg accggccgtg gtcggccggc aaaggatgca
2134261 caaccggatt gatcaggccg gcggtagggc ctggcaatac gactgtgttg ctgtcgtcag
2134321 ggcccgttga tagaggctat cgaggtggcg ggaccgcact atgtcgcgtt tggcgcggtc
2134381 gagttgggcg gcgcaggacg gcgcggacag caaactccag tgactccaaa tctgcgacag
2134441 catccgatta ttcagggagt cgatcgccga tcgcgatgcc gatagatccg gcggctccgg
2134501 gggcgcgctg gccgggttga gcttccagtc cgagaaccgg ctgtactcga ttgcctcggt
2134561 ggcgcgaatc tggtcgtcga agacgcgggt gacgtagtcg gggtcgatgt gctgcgagcg
2134621 ggcatcttcg cccaactttg cgagttgctg ttcgactcgg ccggaatcct caatgggcag
2134681 ctgagcacgc cacttgaagg ctgccaccgg gtcggcgacc tccaaccgct cagcggcggc
2134741 gtcgaccaac tcggctaact ggctggtgcc gtcggctcgc gccagcgggg ggcctagtgg
2134801 tgcaatcagc gacaacagga tgccgatcga gacggcggtc gcgaggtata tctcacgtgg
2134861 acgggtaagc aacccttcgg ttgatcccgt cagccggcgc ctaacgaact ctgcaggtca
2134921 cccttcatgg cgttgagctg agcgccccag tactcccagc tgtgcgtgcc gttgggcggg
2134981 aagttgaaca cggcgttgtg cccgcccgcg gcgttgtacg catcctggaa cttcaggttg
2135041 ctgctacgaa cgaagttctc caagaactcg gcgggtatgt tggcaccgcc caactcgttc
2135101 ggggtgccgt tcccgcaata aacccatagc cgggtgttgt ttgcgaccag cttggggatc
2135161 tgctgcgtag ggtcgttgcg ctcccatgcc gggtcactcg agggacccca catgtctgcg
2135221 gccttgtaac cgccggcgtc acccatcgcg aggccgatca ggctaggccc catcccctga
2135281 gaggggtcca gcagggccga cagcgagccg gcgtagatga actgctgggg gtggtaggcg
2135341 gccaagatca ttgccgacga gccggccatc gacaagccga ttgcagcgct gccggtgggc
2135401 ttcacggccc tgttggcgga caaccattgc ggcagctcgc tggtcaggaa ggtttcccac
2135461 ttgtaagtct ggcagccagc cttaccgcag gccgggctgt accagtcgct gtagaagctg
2135521 gactgcccgc cgaccggcat gactatcgac agtcccgact ggtagtacca ctcgaacgcc
2135581 ggggtgttga tatcccagcc gttgtagtcg tcttgggcgc gcaggccgtc gagcagataa
2135641 accgcaggtg agttgttccc accgctctgg aactgaacct tgatgtcgcg gcccatcgac
2135701 ggcgacggca cctgcaggta ctcgaccggc agccccggcc gggagaacgc gcccgcggtt
2135761 gccgctccgc cggcaagccc caccaggccc ggaaggacta cagccgctgc cgtgccgatc
2135821 atcaatcggc gtccccaagc tcgaatcttt cggctcacgt ctgtcatact tgtgcccctt
2135881 tgtcctgtat gtcgtcgtgt gctcgggcca gaacataccg tgtgtggagg ccaaatgtcg
2135941 attcgggcgc aaagtcgtct catttccgta tcggttaccg ccgcggacag agcaagtgtg
2136001 cttagggggc tcacaaacgg tatggcggta tggatctatc gcggatttct cagaatcgcg
2136061 gcccggggct accggctgtg ctcccccagg gaggccgaac ttgcgttcac cgcgtaggct
2136121 cgctcgaagc aagccgacga agaccacgct atcccggtct gttccggcgt ccgcgtaaca
2136181 ccgcactggg gtttgtggcg tgcgatggtg cgggctgagg gcatcggagg ttccgggaac
2136241 gattgaggtg cgagaatttg gacacggtac ttgggctctc gataacgcct accaccctgg
2136301 ggtgggtcct cgctgaagga cacggcgcag acggcgccat cttggaccgc aacgaattgg
2136361 agctacatag cggtcgtaac gcgcaggcca tacataccgc agagcagctg gcggcggaag
2136421 ttctgctcgc ccatgaagtg gccgctgcag gcgatcatcg gttgcgcgtc atcggagtga
2136481 cctggaacgc cgaagcttcg gctcaggcgg cgctgctggt agagtcgctg accggtgcag
2136541 gtttcgacaa tgtggtgccg gttcggcggc tacgtgccat cgagacactg gcgcaggcta
2136601 tcgcacccgt tatcggctac gagcaaatcg cggtatgcgt tcttgagcat gagtcggcga
2136661 ccgtcgtcat ggtcgacacc cacgacggaa agacgcagat cgccgtcaag catgtgtgcc
2136721 gcggattatc aggactgacc tcctggctga ccggcatgtt tggtcgcgat gcctggcgcc
2136781 cggccggcgt ggtcgtggtc ggctcggata gcgaggtcag cgaattctcg tggcagctcg
2136841 aaagggtcct gccggtgccg gtctttgcgc aaacgatggc gcaggttacg gtcgcgcggg
2136901 gtgcggccct ggcggcggcc cagagcaccg agttcaccga tgcgcagcta gtggccgaca
2136961 gcgtcagcca accaacggtc gcgcccaggc gatcccggca ctacgccggg gcggcggcag
2137021 cgttggccgc cgcggccgtg accttcgtgg cttcgctgtc cctagcggtg ggcatccagc
2137081 tggctccgca caacgatacc gggacggcga agcacggagc gcacaagccg acgccacgta
2137141 tcgcaaaggc cgtggcgccg gcggtgccgc ctccgccgac ggtcacgcca ccagtccctg
2137201 ctcgggcacc ccggccggct gcgcagcacg aaccacccgc tcgcgtcacc tccggcgaag
2137261 cgctcacgga gccgaacccg cctgaggagc aaccgaatgc ttctgcgccg caacaggatc
2137321 ggaatgacag ccagccgatc actcgagtgc tagagcacat acccggcgct tacggtgact
2137381 cggcaccccc agctgagtag tcggaggccg ccgtagccgg ttgcgaaacc tgttcgcgcg
2137441 gacccatgtc gaggcgaagc ggtgggtact cgtcgcgcat cagcgtggtg tatgcgcgga
2137501 cccgcaacgc ccaccggttt acaggttgta tagccctatg gggtaccggc cggtgaacag
2137561 gagcgccacc acggcgacga gcagcaggat caccagtagc gaaggccaca ttatgccgac
2137621 gcggtcgtgg gggtcgatca ggaagactcg ccaaccgctg gagaggaaga ccgccaggat
2137681 caggtagtgg gggatagcaa gtagccacca cttaatcagc accaggccgc ggctcaaccg
2137741 ctccggatag tcaacctcca agtcagccgg atactccgcc tttgtctgca ggctgaaggg
2137801 cgggtaccgg tcggttccca gcgccgacag cgcatagaag gcaacccgcc agcgccaccg
2137861 catgacgccg acattgaagt cgaacagcgt ccggggatat ctgcccgtga acaggatggc
2137921 aaagaacgcg atcacggtga ccaccacggc ggcaacgtgc aagaagaaca agacaatgta
2137981 gtgcgggatg gccaaaaacc acttgactag ccactgccaa cgtgacaacg caggatcgag
2138041 gtcaccccgg acccggactg gataggcgtc aggttgcatg atcgacggct cctttacatg
2138101 cgcgtcggct cgatccacga gccaggccca ttgtctctca tctgccgcgc atgggcgaag
2138161 ccatcgtcgt gcgctacgga caccggatcg acgtgcagta atagccttgg gctgtaggca
2138221 gctttccggg cgatgacggc ggcactggta atccattgtc ggccaacaat ttactgagag
2138281 gggtcggtac agattgccag ccgtggctat ccaggtacgt ggcaacgtcg ttgcgctcgc
2138341 cgtcgctgta tagcaggttg ggtgatttct atgtcgaacc cgtggacgct ccagcgctgc
2138401 gaagcggtgt caaggaggtc ggatgccggt ccgccatcgt catctaccga ctccccggcg
2138461 cgctgagcgc ggtgatgttg tccagcaagc gatcctgagc gtcgggcggc aggaatgcca
2138521 gcaggccctc ggcgagccag gcactgggtt ggttggggtc aaagcccgct tggcgcaacg
2138581 gggtcggcca gtcacgtctg aggtcgacgg gaaccacgcg aggtcagctg ttgcagtggc
2138641 atccagatca gcaagtgtcg tcatcggtat gcgcgcgcgt caagacctga ggccaggatg
2138701 acagcctgcc gaatccccgc agacgtcgcg tcacggaaaa acgcatcgaa gtaccgcgtc
2138761 cgggcggcca acaggtcggc caatcgctgc agtccccacg tgccgtcggg gtcgtcgacg
2138821 tcggtcgcct tgatgtttcc ggcggcccag cgagtgaaga agtcaatccc cacggctctc
2138881 accagtggtt cggcgaacgg atcatcgatc agcgggttat cggccctggt ggccaccgcg
2138941 cgggcggcag ccaccatcgt cgccgttgct ccgacgctag ttgccaggtc ccacgcgtcg
2139001 ttgttggtgc gcggcatcgg gatcctttcg gctcggccag cgatatacag ccttcgaagt
2139061 ccaccgcttg tgggatcaat cgtcctttgc ccgaaccgcg gtgaatgcca cgctcacttc
2139121 gtcggcgacc cgtattgaac ccatcaacag cgagtagggt ttgacgccgt agttggactg
2139181 gcgaaccgtg gtgtcggcag agatgcgcca cgcagcacca agatcctctg tgtgcaagtc
2139241 gatgacgtgt tctcgcgact ttccccggat gtgcagtttc ccggtcaggc ggtacccatt
2139301 cccggtctgg gcaatggctt ccgtggtaaa gcgaatatgg gggaagcggc tggcgttgag
2139361 cgttttcagc gcgttcgccc gcaccagagc tttctcaggc tcggacagcc ccttcacgcc
2139421 accctcaccg cgcatcacct cgaaggaatc cacctcagcc acaagctcgc cggcgacggg
2139481 atcggtgccg gaccagttca ccagggcctg ccaccgtgtc atcgcgatgg tcaggcgatg
2139541 acccaagcgc gcggctctgc caacgactcc ggtgcgaagt accagctcgc cgtcggaagc
2139601 atcaagagtc cacaccgcgt cgctcacgcc acgactgtat tcagacgacc tgcctgcccg
2139661 cccctcccgc cgcgtcttgt gggccacgac acaatcgtta tgcttggtga ggctcgccgg
2139721 tgccgttgga ggggtgcaac atgattcgcg aactggtcac caccgctgcg atcacgggtg
2139781 ccgcgatcgg tggggcgcca gtcgcgggcg cagacccgca gcgttatgac ggcgatgtgc
2139841 cggggatgaa ctatgacgct tcgctgggcg ccccatgctc cagctgggag cgcttcattt
2139901 ttggacgagg cccctccggt caggccgaag cctgtcattt tccgcctcct aaccagttcc
2139961 cgccggccga aaccggctac tgggtgatct cctacccgct atacggcgtc cagcaggtcg
2140021 gtgcgccgtg tccgaagccg caggcggccg cgcagtctcc ggatgggttg ccgatgctgt
2140081 gtctgggagc ccgtggatgg cagccgggat ggtttaccgg ggccgggttc ttccctccgg
2140141 agccataacc ggtgggcgtt tctcatgatc atgtgcgaag gccggcccac cgaatcaccg
2140201 atcccacggt ggctgcgctt cgtgcttacg tctgaccgtg ccggctcggc atggtatatc
2140261 ggggcaggct tcttcttcgc gccagtgctg gcggtgcttt cgccatggcc gaccatcacc
2140321 gcggtgctgt ggtggatcat cggactggcg ggactatggc tcggactgct cggaatcgcg
2140381 atggcagtcg gactggcccg ggtgttgcgt tccggcgccg aaataccgga agcctactgg
2140441 cgcacgctgg tcgactaccg atccgccaac gaataggaga ctccgatgag cttcaatccc
2140501 aaagatgcgg tcgacgctgt ccgggacatt gcggccaatg ccgtcgagaa ggcctcggac
2140561 atcgtggaaa acgccggcca catcatccgc ggcgacatcg ctggcggggc cagcggcatc
2140621 gtcaaggact ccatcgacat cgccacccac gcggtcgaca gaacgaaaga agtgttcacc
2140681 ggcaagacgg acgacgaagg ttagtcgaga ctagtcggcg cgcgcttgtc gtccgttgtc
2140741 aaacggacgc ggcagcattg agtgcgtcca accgggcggt cgcctcgagg tactcctgca
2140801 cccagcgttc gataacggta gccgtctttt ccaccttggt gaactgccca acaacctgcc
2140861 ccaccgggtt gaacgcgacg tcgacggtct cgttcgggta tttatgtgtg gctttgacgg
2140921 ccatgccgga gaccatgtat tgcaacggca taccgagcgg cttcgggctc tccggttgct
2140981 cccaggcctc agtccagtcg ttgcgcagca tccgggccgg cttacccgtg aaggaacgac
2141041 tgcgcacggt gtcgcggctg gtcgccttga cgtatgcggc ctgttgaacc gcggtgtttg
2141101 cggcttcctc gaccatcagc cactgcgaac cggtccatgc cccttgggtc cccagcgcca
2141161 acgctgcagc gatctgctga ccgctgccga tgccacccgc cgccaacacc ggaaccggcg
2141221 ctacctcctt gacgacctga ggccacaaca caatggagcc cacctcgcca cagtgcccgc
2141281 cggcctcgcc gccctgggcg atgatgatgt cgacgcccgc atcggcgtgc ttgcgggcct
2141341 gcgagggtga gccgcacaat gcggccacct tgcgacccga gtcgtggatg tgcttgatca
2141401 tgtccgctgg gggggtgcca agcgcgttgg cgaccatcgt catcttgggg tgcttcagcg
2141461 ccgcgtcgac ctgtggggtg gccgtcgcct cggtccaacc gagcagctgc agactgtcct
2141521 cgtcggcgtc ctcgaccggg acaccatgat cggcgaggat cttgcgggcg aagtccagat
2141581 gctcctgcgg gaccatcgac cgcagcgtct tggcgagctc atccgccgac agctgggagt
2141641 ccatgccctc gtacttgttc gggatcacga tgtcgacccc gtaggggtgg tcgccgatgt
2141701 gttcatcgat ccagttgagc tcgatctcca gctgctccgg cgtgaaccca actgctccga
2141761 gcacaccaaa accaccagct ttgctgacgg cgaccaccac atcgcggcag tgagtgaagg
2141821 caaaaatagg aaactcgata ccgagctcgt cgcaaatggc agtgtgcatg cctgctcctg
2141881 gaatgctagc ggacgcaaat agaactgaaa cgtgttctag tttagtaccc gtcttggtaa
2141941 ggtggccaac agcccaggtt ccggtcgggt ttcggcgcgc accccggcga agctgacgag
2142001 gcggtctaag gtcaccttca cccgcgcatg gccggccagc aacaacgacg gctgtcccac
2142061 cgagcagaag tactgggcga tggtgtgcac cgcggtcggc taccaccgcg acgaccccgc
2142121 cgcagaactg ctgttacgca acgaaggctt ggcagctgca gtccaaactg gccacctacg
2142181 tctacccgcc acagaaacta gtcgccaagg tccgtgcggg cgccaaagtg tccgacaacc
2142241 acgaccaggc gaccactctg ttccaccacg cgatcgatca cccaaccgtg accgtgcagc
2142301 agacctactc cctgatcaac cctcaatcgg ccccggggcg atggaccttg atccgctggg
2142361 gccccgccgg tagcctagtg ctgcgaatta cgctatgccg agtctcggaa ttgccggccc
2142421 gccgttcacc acgttcaaac gcccgagacc ggtgccaggc aggtacgcga acctcatggg
2142481 tctcaattcg ttctgccaca aagaaagtga gtaagccagc atgcgtgcgg tagtcatcga
2142541 cggggccggc agcgtcagag tcaacaccca gcccgacccg gcactgcccg ggcctgacgg
2142601 agtggttgtc gccgtgaccg ccgccggcat ctgcggatcc gatctgcatt tctacgaagg
2142661 cgaatatccg ttcaccgagc cggtggccct cggtcacgag gcggtaggca ccatcgtcga
2142721 ggccgggcca caggtgcgca ccgtcggagt tggcgacctg gtcatggtgt cttcagtggc
2142781 cggctgcggc gtctgcccgg gatgcgaaac ccatgatcca gtcatgtgct tctccggccc
2142841 gatgatcttc ggcgccggcg tgcttggcgg cgcacaggcc gatctgctgg cggtgccggc
2142901 cgccgatttc caggtgctca agatccccga aggtatcacc accgagcagg cactgctgct
2142961 cacggacaac ctcgccaccg gttgggcggc agcccaacga gccgatattt cattcggctc
2143021 cgccgtggcg gtcatcggcc tgggagccgt cggcctctgc gcgctgcgca gcgccttcat
2143081 acacggtgcc gcaacggttt tcgctgtcga ccgagtaaag ggacgcttgc aacgcgcggc
2143141 cacctggggt gctacgccga taccgtcacc ggcggccgag acgattctgg ccgcgacgcg
2143201 gggtcgcggc gcagactcgg tgattgacgc cgtcggcacc gacgcctcga tgagcgacgc
2143261 gctcaatgcg gtgcgccctg gcggcaccgt ctcggttgtc ggcgtgcacg atcttcagcc
2143321 gtttcccgtg cccgcactga cgtgcctgtt gcgaagcatc acgctgcgaa tgaccatggc
2143381 accggtacaa cgaacctggc cggaactgat cccgttgctg cagtcgggcc gactcgatgt
2143441 cgatggcatc ttcactacca ccctgccgtt ggacgaagcg gccaagggct atgcaaccgc
2143501 gagggcgcgc tcgggtgagg agctaaggtt ctgcttacgc cctgacagcc gtgatgtact
2143561 gggagcgcat gaaactgtcg atctttacgt ccacgtccgg cggtgtcagt ccgtagccga
2143621 cctgcagctc gagggtgctg cggacggggt cgacggccca tccatgctca actagccact
2143681 ccacgggatc ggtcttgtcg tcgtaggtga gcgcggagaa attcacgtca ccagacatat
2143741 tgacccccgg gtgtgcggtt tccagcgcgg cgagctgctc gtgatccaac cgggacccta
2143801 aggcgcccaa ggcaactcgg ctgccaggcg cacacaactc atcgatccgg gcgaacagag
2143861 catattgcgc atcgccggtc aggtagggca gtagtccctc gaccgaccag gcgctgggtc
2143921 gttgcggatc gaacccggcc gctgtcagcg gcgtgggcca gtccgtacgc agatctgctg
2143981 gcaccgccac ccggtgagct ttgggtacag caccccgctc acttagcacc cgtgctttga
2144041 attccaggac cttcggcaca tcgatctcga aaaccgttgt cccgggctgc cagtcaaggc
2144101 gataagcgcg gcagtccaga ccggcggcga cgatcaccgc ctgtcgtatg ccagcctcat
2144161 cagcgcagtt gaagaagtcg tcgaaaaacc gggtttgcac gccgtagagc cgagggaaag
2144221 cggtgccgtc ctccgacgtt ctcgggtttg ctaacagacc ctccagatac gggtcggccg
2144281 aagcggtgat gaaatgcttc gcgtattcgt cttggaccag cggtttaggg cccgtggtgt
2144341 gcagtgcacg ccaacccgca accagtagcg cggtgtagcc cacgttgctg acaatgtccc
2144401 agtggtcgtc atcggaacga agcgagccat actcaggtgt agtcatctca tcagccttcc
2144461 agcattacgg tcaccggacc gtcgttgacc agttcgacct gcatgtgggc accgaacacg
2144521 ccggcttcca cgtgcgctcc caactggcgc agcgctgccg cgaacgctgc tatcaggggc
2144581 tgcgccaccg cacctggcgc cgcggcgttc caggacggtc gccgaccctt cgcggtgtct
2144641 gcgtagaggg tgaactggct gattaccagg atcggtgcgt gcatgtcgga ggcggatttc
2144701 tcgtcggcga gaacccgcaa attccagagc ttttcggcga gacggcgcgc cttgtcgaga
2144761 tcgtcgccgt gggtgacacc gacgaacgcg accaggccct gcccgtccgg ccggatagcg
2144821 ccgaccaccc gaccatcgac cctcaccgca gccgatgaga cccgttgcac cagaacccgc
2144881 acgagcctcg atgctgccag gccggctatg cagtcgctgg ggctgggtag gctcattgtg
2144941 tgtctgtgct ggtcgcgttt tccgtcaccc cgctgggcgt gggggagggg gtcggcgaga
2145001 tcgtcaccga agcgattcgc gtggtccgtg attccggcct gccgaaccag acagatgcca
2145061 tgttcaccgt gatcgaaggc gatacctggg cggaagtgat ggccgtcgtg cagcgcgcgg
2145121 tggaggccgt ggccgctcgg gcaccgcgag tcagcgcggt gatcaaggtg gactggcgtc
2145181 ccggggtcac cgacgcgatg acccagaagg tcgctaccgt cgagcggtat cttctccggc
2145241 ctgaatagca gcgctaaacg cccgctcggc cgcatcccca tggaccgcaa ataccaccct
2145301 ttgcagcgac cccggccggt gccgacggac ggcgccgacc atcagccgcg cagcgtcgtc
2145361 gagcggaaag ccgcccacgc ccgtgccgaa agccaccagc gccagcgagc ggcaaccgag
2145421 ctcgtcggct ttccgcaggg tagcagcggt ggctgcggtg atgatctcgc ccgaggtcgg
2145481 acctcctagc tccatcgtcg ccgcgtggat cacgtagcgc gccggcatgt caccggccgt
2145541 ggtctcgacc gcttccccaa gcccaatcgg cgccttctcg gtggactcgc gctgcagctc
2145601 ggggccgccg gcgcgggcga tggccgcagc gacaccaccg gcatgccgca gtcgggtgtt
2145661 cgccgcattg gtgatggcgt cgagctcgag cttggtcacg tcggcctgat gtacctccaa
2145721 ctcgatcatc gacacattgt cccccctgca agtactcggc ggccgcggtg atgcacccct
2145781 tgttgtgttg gaccgtcgcc accatcgccc acacaatcga accctcgccc ggcgccactg
2145841 cggcccatcg agactccggc ccatcgagcc cagattcagg gtagcttgag gtgaacgagg
2145901 acaatcaagc ggctggcaag gacacagacc gatggctcgt gatccagttg taccgagggt
2145961 gcgaacagca tgagtggcga cgacgccggg ccgggcgagg tcagccatgc ccgcggcgtc
2146021 ggtgggccgg gcggagccgg aggcgccggt ggccggggtg gtgccggcgg tcgcggcggg
2146081 gcgggcggta gaggcggaga tggcggcata ggcggggcag cgggccccgg cggtcaaccc
2146141 ggccagggcg gggtgggcgg cgcacccggc cccggtggaa cccccggcga accaggtcag
2146201 cccggcaaac caggacaacc ggggcaaccc ggcagcccgg gacattagcg cgtgcgggtg
2146261 gcgtcgtcgc gcatgagcac gcatagccgc catctgcccg gtacgccctt gagttcctgc
2146321 tcaccacgct cggcgaaccg gtgccgtgat ccggcgacga tgtctcgcac ggtcgaggac
2146381 accagcacct cactgggtcc ggccagcgcg cagacgcgcg caccgatatg cacggccacg
2146441 ccggcgacgt cggtaccgtg cgaggcatcg cgcacctcga cctcgcccgc atgaataccg
2146501 atccggacct caatacccag cgcggcgacc gcgtcgacga tgtcgtccgc gcacgcgatc
2146561 gcggcactcg gactggtgaa cgtcgcgacg aaaccgtcac cggccgtgtt cacttcgcga
2146621 ccgccgaacc gctggatttc gtggcacacg atggtgtcgt ggttgtccaa caggtcgcgc
2146681 catcggtcgt cgccgagcgc ggcggcgtgc tgggtcgagc cgacgatgtc ggtaaacatg
2146741 atggtggcaa gcatgcgctc ggcgtcagcg ccgccgcgca cgccggtgat gaattcctcg
2146801 atttcatcga gcatcggccc ggtgtcgcca acccagtaca gggtatcggt gccgggtagt
2146861 tcgaccaagc gggatccagc gatgtgctcg gcgaggtagc gaccatgtcc caccgggatg
2146921 tacgtcgatc cgacacggtg caagatcagt gttggagcct cgatgtgtcc caagacatct
2146981 cgtacgtcgg cctcggctat gacctttgaa acggcacggg caatgctcgg cggtccggca
2147041 cggttgccgg cgagatccca ccaggctcga aacacgtcat ctccggccac ggtaggagcc
2147101 acgatgctca gcacgtcgaa gccccgctcg acggcatccg gttccagcgc caccgtcagg
2147161 aacgggtcag ctcgacgaac ctgggcgcct accgggtagt cgggcgccca tagtgggcgc
2147221 gccgagccgt tgacgacgat caggctgcgc acccgctcgg ggtagtcggc ggcgagaaca
2147281 agtccgttca tggcgtggaa actgggcgcg aaaattgtcg cctgctcgca tccgaccgcg
2147341 tccatcaccg cgatcgcgtc ctgggcccag aacttcggcc ccagcgtggt tatcgcggcg
2147401 agccgtgacg acaggccgac cccacgatgg tcgaggcgga tcaccctgct gaatgacgca
2147461 agacggcgat ggaaacggta cagcgatggc tcgtcgtcga tcgagtcgat cggcacgaac
2147521 ggccccggca acaccagcag atccgtcgga ccgtcaccca gcacctggta ggcgatatcc
2147581 atgtcgccgc attttgcgta gcgggtcctg tgaatgtggg gagcctgcgc cacggtccta
2147641 cgttagttca tgcgtaggct catggcggtg agcgcacgtg cgggcatcgt gatcaccgga
2147701 accgaggtcc tgaccgggcg ggtccaagac cgcaacggcc cctggatcgc cgatcggctc
2147761 ctggagctcg gggtcgagtt ggcacacatc acgatctgcg gcgaccgtcc cgccgacatc
2147821 gaggcacagc tgcgattcat ggctgagcag ggtgtggacc tgatcgtcac cagcggcggc
2147881 ctggggccga ccgccgacga tatgaccgtc gaggtggtgg cgcgctattg cgggcgcgag
2147941 ctggtgctgg acgacgagct ggagaacagg atcgccaaca tcctcaagaa gctgatgggg
2148001 cgaaatcccg ctattgaacc cgccaacttc gactccatac gcgccgccaa ccgcaaacag
2148061 gccatgattc cggccggatc gcaagtgatc gatccggtgg gcaccgcccc cggtctggtt
2148121 gtgccgggac ggccagcggt gatggtgctt cccgggccac cgcgcgagct gcagccgata
2148181 tggagcaagg ccatccagac ggctccggta caggatgcga ttgccggccg gacgacctac
2148241 cgacaggaga ccatccggat cttcggcctg ccggagtctt ctctggccga cacactgcgt
2148301 gacgccgagg cagccatccc gggttttgac ttagtcgaga tcaccacctg cctgcggcgc
2148361 ggcgagattg aaatggtcac tcgctttgaa ccgaacgccg cgcaagtgta cacgcaattg
2148421 gcacggttat tgcgcgaccg gcacggccac caggtctatt cggaagacgg tgcgtccgtg
2148481 gacgagctgg tcgcaaaatt gctaactggc cgccggatag cgaccgccga atcctgcacc
2148541 gcagggttgc tggcggcacg gctcaccgac cggcccgggt cgtccaagta cgtggcgggc
2148601 gcagtggtgg cctactctaa cgaggcgaag gcacagcttc tcggtgtgga tccggcgctg
2148661 atcgaggccc acggggcggt ttccgagccg gtcgcccagg caatggcagc gggggcgctg
2148721 caaggcttcg gcgccgacac cgccaccgcg atcaccggaa ttgcgggtcc gagtggggga
2148781 acgccggaaa agcctgtggg aacagtgtgc ttcaccgtcc tgctggacga tggccgaaca
2148841 accacccgaa ccgtgcggct gcccgggaac cggtcagaca ttagggagcg ctcgacgact
2148901 gtggcgatgc acctgctgcg gcgcaccctg agcggtatcc cgggctcacc ctagcgacgg
2148961 cgaaatcgac agcagcgcga caaagttcga cgagaagaca ccgcgctaat gtcgatttcg
2149021 atgacgaaca agaaaagcag tttccgtagt accaaagcgg attccggtgg catccttgcc
2149081 aatcgccgtc agcaccgcta cgaccaatag cacgggcacg atcgtcgcgg ccaaggcgaa
2149141 ggggtagcca tgggattcgg ccagacgctc ttgaatagga aggttgaacg ccgccagcag
2149201 attaccgagc tggtaggtta cgccggggta gacgccccgg atagcgtctg gcgacatctc
2149261 ggtcagatgc gcggggatca caccccaggc accctgtacg aagacttgca tcaaaaacga
2149321 acccaggcac aacatcgccg cagtgcgcga gtaagcgaac agcggcacga tcggcagtcc
2149381 cagcgccgca cagaaaacga tggtgtaacg gcggctgaac cgctgggaca acgtgccgaa
2149441 cgccagaccg ccgatgatgg cgccgatgtt gtagatcacc actatccacc tggcggtcag
2149501 gctggacaaa ccggcaccat gatcggtagt cgcggtcagg aaggtcgggt agacatcctg
2149561 ggtgccgtgg ctcatccagt tgaaggcggt catcaacagc actaggtaga caaaccggcg
2149621 cacaattgcg gggttaccca ggacatcgcg gattcgggtc ttggtgagcc gcatgcggtc
2149681 ctgcgcggct tcccagactt cggattcctt tacccggtac cggatgatca agctgatcag
2149741 agccgggatg atgcttaggc cgaacaacca ccgccacgac agccctagcc agttcatcac
2149801 caccagcgct gccacactgg ccagcagata gccgaacgcg tagccctcct gcagcagccc
2149861 ggagaagacg ccacgccgct cggctggaac cttctccatg gacagcgcgg cacccagccc
2149921 ccactctccg cccatgccaa tgccgtagag cagtcgcagg atcaccagca cggtgaagtt
2149981 gggtgcgaat gcgcacagaa atccgatcac cgaatagaac gacacgtcga ccatcagcgg
2150041 gacccgccgg cccacccggt cggcccatag cccgaacagc aacgcaccca cggggcgcat
2150101 ggccagggtg gcggtggtga gaaacgcgac gtcggtcttg gtgtggtgga aggtcgttgc
2150161 gatgtcggca tagaccagca ccacgagaaa gtaatcgaac gcatccatcg tccaacccaa
2150221 gaaagatgcc ataaaagcgt ttcgctggtc gccggtcaac cgcggtgctg ccacgtctgc
2150281 atcgtggcgt accgggcgcg gcaccgcgag tccggggaca tggcgaacag cggcggctcg
2150341 catgtccgtg gcaggatcgg gcaatggtgc cttttctgat gcgcgccgca gtgaccggat
2150401 tcgcattatg ggtggtgact cttttcgtcc cgggcatgcg gtttgcgggc ggcgacacaa
2150461 cgctgcagcg ggtcgccatc atcttcgtcg tcgcggtgat cttcggtctg gtcaacgcgt
2150521 tcatcaagcc catcgtgcag atcttgtcga tcccgttgta catcctgact ctcggtcttt
2150581 tccatgtagt cgttaacgcg tcgatgctgt ggcttaccgc gtggatcact gagcacacca
2150641 cccactgggg actgcagatc gaccacttct ggtggaccgc gatctgggcg gcgatcttgt
2150701 tgtcgatcgt cagctggatc ctgtcgctgt tggctcgtga ctttcgacgt gtcactcgcg
2150761 cacactagag ccacaaattt tggtgggggg acatcctagg ttttcggggc atgttccact
2150821 tatgcttact cacactgctt gccaacctcg tccaagacag gcaccctgtc ttcggcgtga
2150881 tgacgctgac ctcccgccct ccaatacgcc ggacggcagc acctaacagc acacgacgac
2150941 gggactgcaa atgatgcgca ctgtcgcgat tggaccaggt gccggtcctt cgagcacacg
2151001 gccgagttcg caacccagtg acctgcatag cggcctacgc gcggttaccg agtgcaccgg
2151061 ctcagcggtg gtcgttcatg tgggcggcga catcgacgcc agtaacgagg tcgcttggca
2151121 gcgtctggtg agcaagagcg ccgctatcgc catcgcgccg ggtccgttcg tcatcgacat
2151181 tcgggacctc gacttcatgg gatcatgtgc atacgctgtg ttggcccagg agtcggtgcg
2151241 gtgtcgccgg cgcggggtga atatgcggtt ggtgagtaac cagccgatcg tggcccgcac
2151301 cattgccgcg tgcggactgc ggcgactaat tccgctgtat gcaacggtcg agaccgcact
2151361 ggcgccgcct cccagcgcgc attgaccgac ccattaaccg accggtgcca cccaacccgc
2151421 catggtgtcg ggttaaccgc cgccgacaag attgaccacc tcccgcgcac aaccccatga
2151481 cagggtcacg ccgtcacctc cgtggccata gttgtggatg cacagcgctc gcccgatcgg
2151541 ttcagcttcc acccgcacgg acggccgatc aggacgcagc ccggtaatcg tctcaatcac
2151601 tgccgcctcg gcaagccgtg gttgtatgcg gcgacaccgt tgcaggatcc gctcggttat
2151661 ctccggctct ggggtggggt cccacctgcc agggatactg atgccgccgc agactacacg
2151721 ctgcgggtgg gcaaagtagc agatccattc cgagccgccg gtgcgctcga taaacagttg
2151781 ctctagacct ggattggtga ggacgacgtg ctggccgaac cgcggccaga ccgtggcgtc
2151841 gccggccagt tcccgagcgc ccagaccagc acagttgatc actatgggcg ccgcctcagc
2151901 ggcctcggcc agcgaccgta gcgggcgcgt ttcgatttca cagccagtcg ccgccaatcg
2151961 ctgggtcaga cagtcgaggt actggggcat atcgatcatc ggcaaggtgg catgaaaccc
2152021 agcacggaag cccccgggca cgtcggccgg gtcagccggc cgcacgtcgg ggatcagctc
2152081 caacccgggc ggcatcgcac cggtctcgat acgatcgccg acactcagcg ccggcgtcat
2152141 gcgcacgccg gtggcgggat ccttggccaa gtcgcgaaac acgtgcaatg actgttcgat
2152201 ccacccgcgt accttggcaa cgggttcctt cggccgcggc ccccagaccg cacccgccac
2152261 cgccgatgtc gtttgctgcg gcaatgcggc cgcccatacc cgcaccggcc accccgcctc
2152321 ggccaggcat atggccgacg tcagtccgct gacgccggcc ccaatcacga tgacctgttg
2152381 ctcacctatt gccacagcag gaccgtagcc gaagccagcg tcagttaggg ctgaggcact
2152441 cgccctccag tcggtccgag taagccgttg aggatgccga gctgattttg tagttgggcc
2152501 cccgcttcag gtccaggaac tccggcaggg gcagcgcctt cgctgcccgt gttctgccag
2152561 ggttggcagc cgtgcgtctt gaacgccttg tcggtcggct caatcgtcac tacctgtggt
2152621 ttcttgctga gtgcgttatc gatgagcgcg ccatcggggt tacccatccg cttccaatag
2152681 caggtgccgt cgccgacggg tcccgcggag ctgtacgtgc cgggagcgat gtcaatcccc
2152741 accgcatagg tgccgtcgct atcaattgcc gtcttcggtg tcggtgccgg ctccggatcg
2152801 gcgccggcga ggcccacgga tccggcccag cctgcgagga tcaggccggc gacggcaaag
2152861 gctgcagcag gagatggggc tggcttcaag cgcatcacac aatagcctac tggggcctac
2152921 cggtatccgg aactcactcg gcctggaagc aatcactcgt tctcccgccg ccgatgggct
2152981 tgttcgatcc ccatatgcgc ctgcgagcgc acggacggcg cgccaccgac gcagtgtccg
2153041 gcaatgatgc ggtaaatcgc ggacggcgcc aacgcttcca ccgagtcaca gccttgtccg
2153101 ccagcacacc gcccagaccg catgtatcgg aggatgtccg gaagccgttg gccacctccg
2153161 tgtcgagcaa ccaccgctgt cactgcattg ctgtcactaa atcgttgtcc ggcaacacgt
2153221 ttagagcgct cgcgtcaggc tgacctcctg gtggctcgca tcccgagcac cggctgggta
2153281 ccgcgacctt cgtcgaagtc cgccgcccac ggccagcgac cacgccggtc ggcccacacc
2153341 aactgcaagg ccgtcacctt gtcgccaaag atggcgatcg cacaatacaa atgcgcgtcc
2153401 ggatgtgtaa cctggaccgt ttcgacaaga gggccggctg ggagggtggt ctgcataccg
2153461 ggagtcagca agtcaccgac cagagccctg cgagcggcga tgttcaacaa ccgctgccca
2153521 cgtcgtggcg agaggccagt caccaccagt tcgggcaagc cgcgccgggt tagaccaacc
2153581 gtgtaggcaa atggccgtcg ctcgcactcc acgtgctgta ccgcccagcc atgcatgagc
2153641 attatcccgt acacctcgtc gaggtactcc tcggcggtgg cttccgggtg atcgcacatc
2153701 cagcacattt cggcgccctt tctcctcatc cccgtctcgt catccccgtc tcgtcgtgcc
2153761 tgcgaccacc atgcacgcgg ggtctgacaa atcgcgccgg gcaaacacca gcaccccgcg
2153821 agccggtcag ctcgcggggt gctgcggcgg gttgtggttg atcggcgggc agggccgatc
2153881 aacccgaatc agcgcacgtc gaacctgtcg aggttcatca ccttgtccca ggcagcgacg
2153941 aagtcctgca cgaacttcgg ctgcgcgtca tcggcgccat agacctcgac aagcgcccgc
2154001 aactccgagt tggacccgaa gaccaggtcc acgcggctgc cggtccactt caccttgcca
2154061 ctgccatcct tgccctggta ggtcccgtca tctgctggcg agggctccca ggtgataccc
2154121 atgtcgagca ggttcacgaa gaagtcgttg gtcagtgact cggaggcctc ggtgaacacg
2154181 cccagcggta agcgcttgta gtttgcgccg aggacgcgca ggccacctac cagcaccgtc
2154241 atctcagggg cactgagcgt aagcaggttc gccttgtcga gcagcatgta ctcggccggc
2154301 aacgggttgc cctttccgag gtagtttcgg aagccatctg ccttgggctc cagcacggca
2154361 aaggattcca cgtcggtttg ttcctgcgac gcatccgtgc ggcccggggt gaagggcacc
2154421 gtgatgttgt ggccagccgc ctttgctgct ttctctatgg cggcacagcc accgagcacg
2154481 acgaggtcgg cgaaggacac tttgatgttc cccggcgccg cggagttgaa tgactcctgg
2154541 atctcttcca gggtgcgaat gaccttgcgc agatccccgt cggggtcgtt gacctcccac
2154601 ccgacttgtg gctgcaggcg gatgcgacca ccgttggcgc cgccgcgctt gtcgctacca
2154661 cggaacgacg acgccgccgc ccatgcggtc gaaactagct gtgagacagt caatcccgat
2154721 gcccggatct ggctcttaag gctggcaatc tcggcttcgc cgacgaggtc gtggctgacc
2154781 gcagggaccg gatcctgcca cagcagggtc tgcttgggga ccagcggccc aaggtatctc
2154841 gcaacgggac ccatgtctcg gtggatcagc ttgtaccagg ccttggcgaa ctcgtcggcc
2154901 aattcctcgg ggtgttccag ccagcgacgc gtgatccgct catagatcgg atccacccgc
2154961 agcgagaggt cagtggccag catcgtcggg gagcgccctg gcccgccgaa cgggtccggg
2155021 atggtgccgg caccggcgcc gtccttggcg gtgtattgcc aagcgccagc agggctcttc
2155081 gtcagctccc actcgtagcc gtacaggatc tcgaggaaac tgttgtccca tttcgtcggg
2155141 gtgttcgtcc atacgacctc gatgccgctg gtgatcgcgt ccttaccggt tccggtgcca
2155201 tacgagctct tccagcccaa gcccatctgc tccagcggag cagcctcggg ttcggggccg
2155261 accagatcgg ccgggccggc gccatgggtc ttaccgaaag tgtgaccgcc gacgatcagc
2155321 gccgctgttt cgacgtcgtt catggccatg cgccgaaacg tctcgcgaat gtcgaccgcc
2155381 gcggccatgg ggtccgggtt gccgttcggc ccctccgggt tcacgtagat cagccccatc
2155441 tgcaccgcgg ccagcgggtt ctccagatcc cgcttaccgc tgtaacgctc atcgccgagc
2155501 caggtggctt ccttgcccca atagacctca tcgggctccc actggtcgac ccggccgaag
2155561 ccgaacccga acgtcttgaa gcccatcgat tccagcgcgc agttgccggc gaaaacaatc
2155621 aggtccgccc atgagagctt cttgccgtac ttcttcttga ccggccacag cagccggcgc
2155681 gccttgtcca agctggcgtt gtcgggccag ctgttaagcg gcgcgaaccg ctgcatgccg
2155741 cccccggcgc cgccgcggcc gtcgtggatg cggtaggtgc cggcagcgtg ccacgccatc
2155801 cggataaaca gcggcccgta gtggccgtag tcggcgggcc accacggctg cgaggtggtc
2155861 atcacttcct cgatgtcccg cgtcagggcg tcaacgtcga tggtcgcgac ctccgcggca
2155921 tagtcgaacg ccgcacccat cgggtcagcg acggccgggt tttggtgcag taccttcaga
2155981 ttgagccggt tgggccacca gtcctggttt ccgccgccct cgacggggta tttcatatga
2156041 cccacgacgg gacagccgtt gctagcggct ccggtggtgg tttctgtaat gggtgggtgt
2156101 tgctcgggca cagcattcct tccaggagtt ggtgttatcg ggctgtgatc acggatgtga
2156161 tcgcgaagtg tcggatatcg aacaatcagg acatagaccc cagtagatga cctccgcctc
2156221 gtccaacagg aagccgttat ggtccgaggc cgtcagacag ggtgcctcgc caacagcaca
2156281 gtcgacatcg gcgataaccc cgcaagaccg gcagacgatg tgatggtggt tgtcgccgac
2156341 cctggactcg tagcgcgcga cggagcccga gggttggatc tttcgcacca agcccgcggc
2156401 ggtcagggca tgcagcacgt cgtacacggc ttgccgggat acgtcgggca gcgcaaaacg
2156461 cacggcaccg aaaatcgttt ccgtgtcggc gtgtggatgc gcattcactg cttccaggac
2156521 ggcgacgcgc ggtcgggtca cgcgcaggtc ggccgtccgg agctgttcgg cgtagtccgg
2156581 tatagaggac acactagaca atatgactcc cttttctgga atcagtcaag actttggcta
2156641 gcgtgacagg cgtctgctag gacccgatcg ccccggggcc gctggatcgt gggatggcgg
2156701 gtggatcagc cttcgtatgt tccgatgagc cgggcctgca tggtggcggc ctgcgcgatc
2156761 acccgcgccg cttgtgtccc agccagtccc gcgagtggag gcacggcagg aaggtggtag
2156821 agggtaaacc ggtagtggtg tgtcccggtg cccgccggcg ggcaggggcc ggtgtatgcg
2156881 ggctgaccgc tggagttcgg caggctgatt ccgccaccgg gagtctcacc atcggcggtg
2156941 ctgccagcac caggggcgat cccgatcacg atccaatgga cgtaaggttc gcgaggtgcg
2157001 tccggatcat cgacaacgag tgcgccgcca aacggcgccg accaggtcaa cggaggcgcg
2157061 atattggctc ctttgcaggt gtactgttcc gggatcggcg caccgtcggc gaatgccgga
2157121 ctgctgattg tcagtacatc gccggtaggc gtttcgggca tactccgacc gagcgctgct
2157181 gctttcggcg ccagcggcgc cgcctttcga ctgtcaccgt tgccaccgta ggcaactagc
2157241 gccacgggga gcgccagccc caagatggcc agtgcgaacc ggtgaaatgc gtgcgccact
2157301 gtcgattcca tattgatcat tgtcgccagg cgcaattgga gaagccaggg tttcgaccac
2157361 ctcgccaggg atgccgcggc gtcagccttc gaatgtgccg acgagccggg cctgtccgct
2157421 ggcggcctgt gctatcgcct gtgccgcttg gactcccgtg gctcccggtg gcagctggag
2157481 cgcgacagga aggtggtaga gggtaaaccg gtagtggtgt gtcccggtgc ccgccggcgg
2157541 gcatggaccg aagtatcctt gccgaccacc agaattcggc acgctgtgcc caccagcagg
2157601 agtctgacca tccgccgtgc tgccagagcc aggggcgatt ccggtcacga tccagtgcac
2157661 gtacagtccg ccgaccgcgt cggggtcatc gacgacgagt gccagttcgg ctgcgcccgc
2157721 gggcgacgac cacgtcaacg gtggcgccac gttggccccc ttgcagctga attgcaccgg
2157781 gatcggggcg ccgtcggcga acatgggact ggcgatcgtc agtggctcgg cggccggcgc
2157841 cggcgttgtt gcgtcgacgg tcgtcgcttt cggcacgtat ggcggtgtct ctcgactgtc
2157901 accgcccccg cccccgcagc cacccagcgc cactacgagc gccagccccg cggtggctaa
2157961 tggggttcgg tgaagtgtgc tcgtcattgg agattccata gcacattgtt actaactggg
2158021 attcgagagt acagctgttt tgcggccgcg cttaccagac agccgggccc cgggccaccc
2158081 atcgcctcac ggtaccagca ccaccttgtc gacgttctcc cgtgcggcca gaatccgatg
2158141 tgcttcagga gcttcggcga acggcacgat tgcatgaacg atcggcagga tcgttccgtc
2158201 gttgagcgcc ttggtcagcg gcgcgatcca gggttcaagg gtgcggcgat cgtcccacaa
2158261 ccgcagcatg ttaagaccga tcacggtttt cgactcctcg agttgtttca tcaggttaaa
2158321 gccgcgcagc attgacaacg cgtggggcgc caccctgcgc atcgatcgtt tctcgccgtg
2158381 ctgcatattc gaaatcccgt agccaaccag ccttccaccc gggcgcagca gagtgtagga
2158441 ccgccgcagc gaggtgccgc cgagcgcgtc aagcacgacg tcatacgggc ccaatccctg
2158501 ccaccagccg tcccggcggt agtcgatcgc gcggtccaca ccgaactcgg ccagcttctg
2158561 atgtttttgg ggtgatgcgg tgccgtgcac ttcggccttg gctgctttcg cgaattggac
2158621 cgccgcgatg ccgactccac cggccgcggc gtgaatcagc acccgctcac cggcgcgcaa
2158681 cgatccgtag ccgtgcagcg ccgcccaggc ggtcgcgtaa ttcaccggga ccgcggcacc
2158741 ctgttcgaag ctcagcgcat cggggagcac aaccgagtcg gtggccgcaa cgttgacgat
2158801 ctcgcagtag ccaccaaatc gtgtaccggc caggactcgt tcgccgaccc ggttcgggtc
2158861 gaccccatca ccgacagcct cgaccgtccc agcgacttcg tatccgacca ccgccggaag
2158921 tttcggcgcg tctgggtaca ggccgacgcg ggcgagatgg tcagcgaagt tcacccctgc
2158981 tgcgcggacg gcgacccgca gctggcccgg gcccggtggc ggcgggtccg gtcgctgccg
2159041 cacctgcaag accgatgggt cgccatgttt ggtgatgacc actgctcgca taatgttctc
2159101 cttgtcaggc ttgacgggtc gcacccgcga acacccctct gtgatagcac gagttatcag
2159161 gaggttcggc ggggcgttac ctttgcggtt gtgcacttcg actgggagcg cctgaccgac
2159221 agcgtgcatc gctgccggct gccgttctgt gacgtcaccg ttgggctggt ccggggccgc
2159281 accggaatac tgctcgtcga caccgggacc accctcggcg aagcaacagc aatcgcggcc
2159341 gacgtcaagc agatcgctgg ttgccaggta acgcatgttg tgttgacaca caagcatttc
2159401 gaccatgtgc tgggttcctc ggtgttcgac caagcggagg tgttctgcgc tcccgaggtc
2159461 gtcgaatacc tacggtcggc taccgaccgg ctccgcgaag atgccctgag ctacggcgcg
2159521 gacacagctg aggttgaccg cgcgatcgcg gccctgaaac cacctcagca cgggatctac
2159581 gatgcagccg tcgatctcgg ggaccgcacc gtcaccatca ctcaccccgg cagcggccac
2159641 accacagcag atctcgtcgt ggtggcgccg gccaccggcc atgcagacgg cccaacggtg
2159701 gtcttcacgg gtgatcttgt cgaggagtca gccgatcctg atatcgacgc cgattccgac
2159761 ctggcggcct ggccggcaac gcttgatcgg gtacttgcga tcggcggccc tgacgccagc
2159821 tacgtcccgg ggcacgggaa ggtcgtcgat gcgcagtttg tccgtcgcca gcgcgcctgg
2159881 ttgcgaacac gtgcgagccg ccagcctcgt gaaacgccag ctactttgcc gtgcaagcgg
2159941 tgacgagcgc atccgggtcg gtaacgctga cccacaattc gcgcaccgtc atcgacttct
2160001 tccacatctt tgcctgttcg ggcggatcga tcgtcagtgc caccaggccc ttacgtgacc
2160061 cgttgaccag ccagcggccg aatccaaagt gcaccccggc tgcgtagacc cttgcgttgg
2160121 tcgcctctgc cttcgtgatc gacgtcaacg ggatgtcggc ggcaaatgcc catcccatct
2160181 tgacgtgcag gctccccgcc ccaacccata gctcgctgtt cttggggccg agcccgagcg
2160241 gcaccgcaag cgggagaaac caacggtcaa agcgcaactg ggtcggcacc aagatgaccc
2160301 taccggtgct agtgcggctc agtaccatgt aggagttagt ctcgaaccgc cccagtggcg
2160361 ttgcggaatt tgcgagccgt catcggtcag tgatctaggt cgcccgtccg gggatacact
2160421 cggtccgtca ggtgaatcgg ggctgcagag gagcgcaagg ccatggccat cgccgaaacg
2160481 gacaccgagg tccacacacc gttcgagcag gactttgaga aagacgtagc cgccactcag
2160541 cgatacttcg acagctcgcg ctttgctggg atcattcggc tctacaccgc ccgccaagtc
2160601 gtggaacagc gcggcacgat ccccgtcgac cacatcgtgg cgcgagaggc ggcgggcgcc
2160661 ttctacgagc gtctgcgcga actctttgca gcccgcaaga gcatcacgac gtttggcccc
2160721 tactcgccgg ggcaggcggt gagcatgaag cggatgggta tcgaggcgat ctacctcggt
2160781 ggttgggcta cctcagctaa gggctccagc accgaagatc cggggcccga cctcgccagc
2160841 tacccgctga gccaggtgcc tgacgatgcc gcggtgctgg tgcgcgcctt gctcaccgcg
2160901 gaccgcaacc aacactatct acgcctgcag atgagcgagc gacagcgtgc ggcgacaccg
2160961 gcttacgact tccgcccgtt tatcatcgcc gacgccggca ccggccacgg cggcgatccg
2161021 cacgtacgca acctgatccg ccgcttcgtc gaggtcggtg tgccgggcta ccacatcgag
2161081 gaccaacgac ccggcaccaa gaagtgcggc caccagggcg gcaaggtcct ggtgccgtcc
2161141 gacgaacaga tcaagcggct caacgccgcc cgcttccagc tcgacatcat gcgggtgccc
2161201 ggcatcatcg tcgcacgcac cgacgcggag gcggccaacc tgatcgacag tcgcgccgac
2161261 gagcgtgacc agccgttcct tctcggcgcg accaagctcg acgtaccgtc ctacaagtcc
2161321 tgtttcctgg caatggtgcg gcgttttacg aactgggcgt caaggagctc aatggtcatc
2161381 ttctctatgc gcttggcgac agcgagtacg cggcggccgg cggttggctt gagcgccaag
2161441 gcattttcgg cttggtctcc gacgcggtca acgcgtggcg ggaggacggc cagcagtcga
2161501 tcgacggcat tttcgaccag gtcgagtcgc ggttcgtggc ggcctgggag gacgacgcgg
2161561 gcctgatgac ctacggagag gccgtggcgg acgtgctcga attcggtcag agcgagggcg
2161621 aacccattgg catggctccc gaggagtggc gggcgttcgc cgcgcgtgca tcgctgcatg
2161681 ccgcccgggc aaaggccaag gagctgggcg ccgatccgcc atgggactgc gagctggcca
2161741 agaccccgga gggctactac cagatccgcg gcggcatacc gtatgcgatc gccaaatcgc
2161801 tggccgcggc accgtttgcc gacattcttt ggatggagac caagaccgcc gatctcgccg
2161861 acgctcgaca gttcgccgag gcgatccatg ccgagttccc cgaccagatg ctggcgtaca
2161921 acctctcacc atcgttcaac tgggacacca ccggcatgac cgacgaggag atgcggcgct
2161981 tccccgagga gctcggcaaa atgggcttcg tcttcaactt catcacctat ggcgggcacc
2162041 agatcgacgg tgtcgcggcc gaggaattcg ccaccgcgct gcgccaggac ggcatgctgg
2162101 cgctggctcg gttgcagcgc aagatgcgct tggtcgaatc tccctatcgc acaccgcaaa
2162161 cgctagtcgg cgggccgcgc agtgacgccg cattggctgc ctcctccgga cgcacggcga
2162221 ccacgaaggc aatgggcaag ggctccaccc agcaccagca cttggtgcaa actgaggtgc
2162281 cgcgcaagct gctagaggaa tggctggcca tgtggagcgg tcactaccag ctcaaagaca
2162341 aactgcgcgt acagcttcgg ccgcagcggg ccggctcgga ggtgctcgag ctcggcatcc
2162401 acggcgaaag cgatgacaag ctcgccaacg tgatattcca accgatccaa gatcgccgcg
2162461 gccgcaccat cctgttggta cgcgaccaga acacgttcgg tgcggaacta cgccaaaagc
2162521 ggctgatgac cctgatccac ctctggctcg tccaccgctt caaggcgcag gcggtgcact
2162581 acgtcacgcc caccgacgac aacctctacc agacctcgaa gatgaagtcg catggaatct
2162641 tcaccgaggt caaccaggag gtgggcgaga tcatcgtcgc cgaggtgaac cacccgcgca
2162701 tcgccgaact gctgacgccc gatcgggtgg cgctgcggaa gttgatcacg aaggaggcgt
2162761 agccagcgct gccaactgtc ttgggggcca accgggtgtg cgtcgaggtg gcgcacatcg
2162821 cgaaacgcga aggatgctgt cagacggcgt ctgcggtggc ctgtcgaaga tccagcgcac
2162881 cggcgttcac ctgcgtcggc ccgcggtcgc gactaccatc gccgcccccg tttacggccc
2162941 ggcacccggt gagaagaagc ccaggagcat ttggccgatg ttgttgacgc ccgagttaaa
2163001 cgcagcggtg aggtgaccaa cggtgctcgt gttgttgaag cccgagacgg tgttgcctag
2163061 gttcgccacg cccgacgcca gctgcccgac gttgtagatt cccgagactc cgccttgcag
2163121 cgcgttcggc acctggttcc agaggcccga aatgccgggc ccgacgttgc cgaagccgga
2163181 tgcgcttcca tcgccactgt tgaagaagcc cgaagacggg gtggtggtgg agtttccgaa
2163241 gcccggggcg ctcgtgatgt tgatcgggat gttgatcggt cccaagccgc cgttggcggt
2163301 caagttcagg ggggatccgg gaatggtgaa gccggggatc gtaaccgggc tcgtgccccc
2163361 gctcaacgga acattcaacc caaacggatt aatcgcgaaa ccagggatcg taaccgggct
2163421 cgtgcccccg ctcaacggaa cattcaaccc aaacggatta atcgcgaaac cagggatcgt
2163481 gacagcgttg gtagcaccgc tcagcggaat attcaaaccg aacggattaa cactgaatcc
2163541 ctggatgcca gactccaggg tgccgccggc cagcgtgacg cctaatacga atgtgctaag
2163601 cgggatgggg ccgatgtagc ccgtgaagat accagcgacg ttaaacggaa gttcgttgag
2163661 agtgatgttg accggtatcc tgatgttaat cgtaaggggg atgcgggaaa tagggacgcc
2163721 gggaacggtg atcggaccga caccacccag cgcgttcagg ctcaacggaa taccaggaat
2163781 agtaatatca ggcaccacaa tcggaccgac accacccagc gcgttcaggc tcaacggaat
2163841 accaggaata gtaatatccg gcaccacaat cggaccgaca ccacccagcg cgttcaggct
2163901 caacggaata ccaggaatag taatatccgg caccacaatc ggaccgacac cacccagcgc
2163961 gttcaggctc aacggaatac caggaatagt aatatccggc accacaatcg gaccgacacc
2164021 acccagcgcg ttcaggctca acggaatacc aggaatagta atatccggca ccacaatcgg
2164081 accgatgcca ccattcactt cgacgctcag tgggatggcg ggaatgctga gtgtgtctga
2164141 gtagccaatc agaccctggt aatcgcccct ccacagtatg ccgttgctgt agctgcccga
2164201 gatcagggcg ccggtgttaa ggtcgccaat gtttccccag ccggtgttga ggtcgccgag
2164261 gtttaggtac cccgtgttgg cgttgcccgg gttgaggtcg cccgtgttgg tgtcgccggc
2164321 gttgtagctg cctgtgttgt agcttcctgc gttgccgatt ccagtgttga cgttgccggt
2164381 gttgaacagg cccgtgttgg cgttgcccac gttacccagg ccggtgttgt agttgccgga
2164441 gttgccgatg ccgacgtttc cgttgcctga gttgaagaag ccgatgttgc cgttgccgga
2164501 gttgaagaag ccgatgttgc cgctgccgga gttcagcgcc ccgaatccga cctgattgtc
2164561 gccggtgagc ccgataccaa tatttccagt gcccgtgttg ccgaagccga tgttgccgtt
2164621 accgatgttc gcgaagccgt agttgttgcc gccgatgttc ccaaagccaa tgttgtgcag
2164681 ggcctccgtc aaccccggac ccgtgtttgc aaacccaagg ttgttgctgc cgacgtttcc
2164741 aaaaccgaag ttgttgcttc cgatgtttcc gaaaccgaaa cttccgttgc cgatgtttcc
2164801 gctaccgaag ttgtagctac cgacgtttcc gctacccacg ttgtagtcgc cgaggtttgc
2164861 gttgcccaag ttgagtgtgc cgtcgttggc gaagccgaag ttgaataacg tcccacctgc
2164921 ggcgttgcgc atgaagccgg cgagttggct gtcggtgtta ccgacgccgg agtgaaaggc
2164981 cgatgtcgct aggcccagcg tgctggtgtt gtagaggcct gagactgtgt tgccgaagtt
2165041 caagattccc gatgtcagtg gcccgacgtt aaggaatccg gagttgccga gattcccagc
2165101 aatgttccag aagccagatc cgcccgaacc gacgttcccg aaacccgatg tgccgcccgt
2165161 accgctgttg aagaagcccg atgacggggt ggtggtcgag tttccgaagc ctggggtgcc
2165221 cgcgatttcg atcgggatgt tgatcggccc gaggctgccg gacacgtcga tgcccaacgg
2165281 gattgagggg atcgtgattg gcggggtagt gagggggccg atggcgccgc ccacatcaat
2165341 acccaacggg attgccggaa gtgagtagcc atccgggaac accgtaaacg ggcctaaccc
2165401 tccgcccaca tcaataccca acgggattgc cggaagtgag tagccatccg ggaacaccgt
2165461 aaacgggcct aaccctccgc ccacatcaat acccaacggg attgccggaa gtgagtagcc
2165521 atccgggaac accgtaaacg ggcctaaccc tccacccaca tcaataccca acggaatagc
2165581 cggcaaacta taaccacccg ataagaaggt gatgggaccg atttgaccac tcactgtcac
2165641 gtaatctgga gggaatccgg ggaaaaatgg cggaatcgcg ggaatctcag gagtgcctag
2165701 ctgtatcgat atgctacccg ggcctatgct gccaacggtg ggatttacgc cgaataagcc
2165761 gatcgcaagc ggagacgcgg ggatcgaaat cgatcccacg ttaatgacct ggaacgccga
2165821 tagctctagg ccaatagaat ttagagtgat cggcgggatg ttgatggggc caacgagtgc
2165881 cccggtactg ttgatgccca gcccgatggc gggaacagta ataggcggaa cattgatcgg
2165941 ccccaccaac gctccggaac tgttaatgcc caggccgatt tcgggaatgg tgatggacgg
2166001 gatggtgatg gggccgacgg agccgaggcc gttgaggtct aggccagcag cgggaatggt
2166061 cagtgtgccg gagaagccga tcaagccctg gtagtcgcct cgccagaaga agccgttgct
2166121 gtagttgcca gagttgaatc caccggtgtt gacgttgccg gtgtttccca cgccggtgtt
2166181 gaggttgccg gggttgaaga agcctgtgtt ggagctgccc gtgttgaagt cgcccgtgtt
2166241 gaagctgcct agattgaagc tgcccgtgtt gtagttgccc gtgttgccga tgccagtgtt
2166301 ggcgatgccg gcgttgaaga agcccgtgtt ggcttggccc gtgttgccga tacccgtgtt
2166361 gtagctggta cctgagttcc cgatgccgaa gtttccggtg cccgtattgc cgatgccgat
2166421 gttgccggtg cctgagttga acaagccgat attgccggtc cccgagttcc agccgccgaa
2166481 cccctgctgg ttgtcgccgg tgaggccgaa gccgatgttt ccgttgcccg tgttgccgaa
2166541 gccgatgttt ccgttgccgg tgttgcccaa gccaacgttg ttgctgccga catttccaag
2166601 gccgaagttg ttgccgccgg gatttaggct gcccaagttc aaaatgccaa ggttagcggc
2166661 gcccatctgt ccgaagcccg agtttgccag gcctaagcta agatttgcca gcacaccctt
2166721 ggaactggtg atcgccgcgg tgacgacggc cgccggagcg gccgccaact gggcgggcag
2166781 gtctgtcaga ttctgcggcg gcgcagtgaa cggcgtcagg gccgacgcca ccgccgatgc
2166841 cccggcatgg taggccgaca tcaccgacac atcgatggcc cacatctgtt cgtatgcggc
2166901 ctcaatcgca gcgatcgccg gagcattctg cccgaagaag tttgagaaca ccaatgacac
2166961 caggtcggag cggttggccg ccaccagcgc cggttgcacc atcgccgccc ggacagcctc
2167021 gaactcggcc acgagggccg cggcttgggt tgccgaccgc tgggcctggg ccgctgccgc
2167081 ggcaagccat cctaggtacg gcgctaccgc agcggccatc gccgccgatg acggtccgag
2167141 ccacgattcg ccgaccaggc ccgacgtcac ggagttgaaa gaggccgctg ccgaggccaa
2167201 ttccatcgcc agttggtccc aggcgaccgc ggccgccgac atgggttctg atcccgcccc
2167261 gccgaatatg agggccgagt tgatctctgg tggcaatgtt gaaaaattca tggccccgac
2167321 tttccctggg tgcaccgaat tcatggcggc tcaccaaccc gcggtcggcg agcgccgtgt
2167381 cgctcgacgc tactcggcga tcttcgcggc cgtatgcata tcacccgaat agggccatga
2167441 ttcatagatc tcgtcaaact gatttacggc gggcgctttt tagccgctct aggaatcgac
2167501 gccaaaccca acgaacgagc ctcagccaag gccgaaatcg attaattccc cgatgatttc
2167561 atcgttgtgg aggtcgtcgc aggcgtcgtt gatctgatcg tggcgattac ggctggtgat
2167621 cctctccgcg gggcggggtc cgcacggatt atggcgtggt gctctggaag aacaggcccg
2167681 acaggttgtt gccgatgttg gccaaaccgg agaccaagct ggtcacggca aacggcaggg
2167741 tgccggtgtt ggcgaagccc gatatgccgc tgccaaggtt ggagaagccg gagataagac
2167801 caccgtagtt ctggtagccc gagccggcta gcagcccaac aggacttgtg ttgaaccaac
2167861 ccgacagtcc cgagccgctg ttgccgaagc ccgagttccc accgattccg gcgttgaaaa
2167921 agcccaacga gggcgttgcg ctcgagttga agtatcccgg ccccgctggg attgcgaatc
2167981 cgcccatggt ggtgctcggc aggtggatgc tggcgatggt gagtgcgggt gtggtgaagg
2168041 ccgccaagcc caccggctgg atggtgaact ctggcgtggt gatctccggg atattgacct
2168101 gggggagggt gaaaccgcta agtccgatcg ggtcgatggc gaacggtgga gtcgttatct
2168161 cgggcgtcat gatctgagga agcgtgaaac cacccagcgc tatcggatcg atcgtgaacg
2168221 ccggggtggt aatcgccggg atgctgagct gcggcagcgt aaacccaccc agcgtgatcg
2168281 ggtcgatggt caactccggg gtcgtgaact gttgagtagt gatatccggc aggctcaatg
2168341 caccgacacc aatcggactg atcgtcaacg ccggagtggt gaattcttgg gtgctgatct
2168401 ctggcagggt gaacccgtcg accgagatcc ccccgaggga ccacggttgg atgacgacgt
2168461 tggggagggt gaagggggtg acgttgattg cgccgatcga gaagccgacg ccgttgattt
2168521 gacctccacc cacggtaatg gtcccagtat taataaaggc aggaggtgta ttagcgaagc
2168581 cgccaatctg cgggaatacc ccgggcatat tggtttgcaa ggcagtgatg ttgttcggaa
2168641 tgaacaccac caaattagtt atcgtaatgc cgttaaggct aaaggtggga agattgatga
2168701 caccagaatt tgcttgcgtg gctatgccgg gagtgctaaa gccgcctata cttatttggg
2168761 gtgtacttat taacggggtg tgtatcgtgg gtagcgtaaa tccgccgaca gtggtgccag
2168821 ccggaatcgt gatcggcgga accgtcaccg acggaatact cagcgtcggc agattgaacg
2168881 cacctagcgc tgtgccagcc ggaatcgtga tcggcggaac cgtcaccgac ggaatactca
2168941 actgaggcaa gttaaacgca cctaccgtga tgttggctgg tgtcgttgta gctggaatcg
2169001 tcaacgacgg caccgtcaac cccggcaaat caaacgcacc caccgtgatg ttagctggcg
2169061 tcatcgccgc tggaatcgtc aacgacggca ccgtcaaccc cggcaaatca aacgcaccca
2169121 cggtaacgtt ggccggcgtc gtcaccgccg gaatcgtcaa cgacggcaag gttatcgcgg
2169181 gcaggctgaa cgcgggaacc gagattccgg gtatttccag agacggaagc gtcaaatcag
2169241 ggctggtgat ggcgaactgc aggctgcctt ggcccacacc acggtaaaag acaccattgt
2169301 tcatgtcgcc cgtgttgaac aagccgttat tcatgtcgcc tatgttgaag gcgccggtgt
2169361 tgatgcttcc tgtgttgaac cagccggtgt tggcgccgcc cgtgttgaag gtacccgtgt
2169421 tcgacgggcc cgggttgaag gcaccgaagt tgtagtggcc gacgttgaag ctgccggtgt
2169481 tcgcgttccc aacgtcgaac atgcccgtat tgaaagagcc cgcattcagg aatccggtgt
2169541 tgccgtgtcc ggggttgaac aggccagtgc tgaagttacc ggagttcccg atgccaaagt
2169601 tgccattgcc ggagttgaag aaaccgatat tggcgctacc cgcgttgaat aatccgacgt
2169661 taccgttgcc ggaattgagt ccgccaatgc cgatttggtt gtttccagtc aggccgttgc
2169721 cgatattgtt gttgccggtg ttcgcaattc cgaagttgcc gatgcctgca ttggcgaatc
2169781 ccgtgttcaa attgcccagg tttgcaagtc cgaagttgtt ggcgcccgcg tttcctatgc
2169841 cgatgttgtt gccacctagg ttggccgagc cgatattgaa gctaccgaag ttgccggacc
2169901 ccagattgtt gttgccaagg ttggcgttgc cgatgttgcc gagcccattg ttggcattgc
2169961 cgaggttgcc accaccgacg ttggccaagc cgaggctagc ggcgatcgcc cggccggcaa
2170021 aagtcggcat gcccacggcc gtggtgagcg cggtcaccac ggccgcgggc ccggccgcca
2170081 gacccgccgg aagccgcagc gggagggcga atgccggtag cgccacagcg accgccgacg
2170141 ccccggaatg gtaggccgcc atcgccgata catccagagc ccacatctcc tcgtatgcgg
2170201 cttcggcggc cgcgatcgcg ggagcgtttt gaccaaaaag gttcgatatc accagcgata
2170261 tgaggccgga acggttggcg gccaccagcg ccggttgtac catcgccagc cgcacagcct
2170321 cgaactcggc caccatcacc tgggcctggg tggccgcctg ctcggcctgg gtcgccgccg
2170381 cggccagcca ccccgcatac ggggctgccg ccgctgccat cgccaccgat gaccgaccct
2170441 gccacgaccc gccgaccagc ccggctgtca ccgagccgaa agagacagca gccgaggcta
2170501 attcggttgc cagcccgtcc caggccgacg ccgccgccag catcggtccg gagcccgccc
2170561 cggcgaagat caaggccgag ttgatctccg gcggcaacac tgagtaatgc atcgctcccc
2170621 accttccggg gtgagcctgg tgctgatgaa aggtcacacg cccgtcgtcg ctgactcgtt
2170681 cgtagcgcat gagagtacgc ggagatcttg aattgtgtat ccgagcaaat gaaaccgtta
2170741 tctatttgtt atagacatat cgggcacgga tgcaaagttc ttttacacgc tatgcgtaat
2170801 cacgatccgt gcccgtctga tgtaaaccac cgacgtaggc gcactgatat aaatgcattt
2170861 attaccaagg tgattgggtg aaataattac cccggaaaac tgtgctcaat aggaacgatt
2170921 attagtttga atcactgcca taatccaccc tatgtgcaac ccggatgaat tccgatcgcg
2170981 tgcttattcc tgccaaacat tcgggcttta gccctggccc accacgcggg caccaatccg
2171041 acgctgcccc tacagcgaaa tcaccggcgc accgcctccc gctcggccgc cttcaccagt
2171101 tgacccgcga agaacctgac cgcgccaccc agcgccgccc gcatcaccgg ccccgtccca
2171161 cgaacctttt cggtaaacga gccactccag cggagatcgg taccgcccga cgcatttggt
2171221 gtaaggacca cctcgccgaa gtagtcctgg acgggtgtcc tcgcgccaac cagcttgtag
2171281 acgtggcgac ggtcctgctc atactcgacg gtctcttcct gcacgaacac cggccacatg
2171341 cctagtttgc ggatggcccc gatgccgccg ggcgcgggat caccgcgtcg cgcccaactc
2171401 gattgagcaa cgatgggctt ggcccaggtc gcccagttgc caccgtctgt cacgagccga
2171461 aacaaggttg cagccggcgc gctgctggtc ttggtgacct cgaacgaaaa tttccgaccc
2171521 gacatgcgcg actcccgaaa cgacaactga agcggcccga tatggtgctg ccgcgtaccc
2171581 taccgcgcag ccgtccgtgc cggccgtagt ggaccagcca aggtgttccc gcgctggccg
2171641 cagcaggcgc ataatcacga ggtgtcccgc gcagataccg tctcagtgcc ccgtgcgccc
2171701 acccaggctg aggtcgccgc agtgctgcgc atcatgacgc cgctgcgcaa ggtgattaaa
2171761 ccaaaggtct atgggatcga aaatgtgccg accgaacgcg cattgctggt tggcaaccac
2171821 aacacgcttg gcttggtcga cgcgccattg ctggccgccg agctctggga gcgggggaga
2171881 atcgtccggt cccttggcga ccacgcccat ttcaagattc cggggtggcg cgacgcgctg
2171941 acacgaacag gggtcgtcga aggcaccaga gagatcacct cggagttgat gcgacgcggc
2172001 gagctcgtca tggtctttcc cggcggcgcc cgtgaggtca acaagcgcaa gaacgagcgc
2172061 tacaagctgg tgtggaaaaa tcggctgggg ttcgcgcgct tggcaattca gcacggctat
2172121 ccgattgtgc cgttcgcttc ggtgggtgct gaacacggca tcgacatcgt gctcgacaac
2172181 gaatccccac tgctggcacc ggtccagttc ctcgccgaga agctgctcgg caccaaagac
2172241 ggtccggcgc tggtccgtgg tgtcggactg acaccggtac cgcgccccga acggcagtat
2172301 tactggttcg gcgagccaat cgacaccaca gagtttatgg ggcagcaagc cgacgataac
2172361 gccgcacgca gggtgcgcga gcgtgccgcc gccgctatcg aacacggcat cgagctgatg
2172421 ctggccgagc gcgcagccga tccaaatcga tccctggtcg gacggctctt gcgctcggac
2172481 gcctaaggcg cccctgaggc gttcccgggg cctgattcag aagtcagaag accgagtcga
2172541 cttgatcggg gattggggtg ccgtcgttgc gcaataccgg ttgtttcgat ccgtcggggt
2172601 tgatgaatgc ctccccgcat acgtaaggag cgtgctgggg cagcgggtcg ataaacatcg
2172661 ggttgatcgc ccacttaccg cccctggtga acaggccgtc gtaggcccgg cacatgaggt
2172721 cgtcctggtt gcggttgatc acgagtgaca ccacggtggc gtcgccgacg aaggtggcgt
2172781 cgctgttcga gtcgccggcg gcgaggactt gacgacgatc cgccgcgagc tgattgaagg
2172841 cttgcgggcc agtcaccccg aagatgacct gattggccca acaccgtttg ccatcaaggt
2172901 aggtcatgac tgaatcgtcg ccgtcgcgga cgcctccgca accgacgagg tgagcggtga
2172961 gtttcccgga ctggtcggcg acgctgcgga ctccgacgac atgctgatcg tctagaccta
2173021 cctcgcccgc ccacaccttg acgatcggtt cgggtgacgc tgacaccacc caggtgtcga
2173081 taccgtgtgc ctgcagagta ccgatgaggt ctttcatttg tggatagacg cggatgtaac
2173141 catcgacctg ctgtgttccg acctgctggg tggcgccgac atcggcggca aggttctgtt
2173201 tcttggcctg gtctgcgaat ccggcgagct cctcagcggt gtagcccgcc gacagtgcgt
2173261 tgctccacgc gtacggaccc gccaaccggc gcacgttgtt acccacgaaa gccggctgtc
2173321 ccgtggtggt ttcgccgtcg agaagggaaa ggatctcgtt cgcgcacaac gcattgctgc
2173381 cggtcggcag cggcttgccg gcaggtacaa ccttgccgca tgccacgctc agcgcgttcg
2173441 ccgccgcgtc ggtcaggtat cggctggcgg catgccaatc ctggttggct ggctgcagca
2173501 ccaggctgtg ctgcagcatg tagtagttcg tggcgtagcc gatgtcgttc ttgacgacgg
2173561 tgttgtccca gtcaaagatg gcgaccttgc gcgcagaacc gtccgcggtg ccggtgcacc
2173621 tgctgttggc atcgatcgcc gactgcagga attcacgaac tccgtggtgc cacttcagaa
2173681 acgcgtcgag ctgacgacag ccggacgctg gggtcggggg ttggtgggcc gagcagccga
2173741 tgacgccacc gagcacggtt gccattgcca acagcgacgg tatgagtcgc accatgtaag
2173801 cccttcgtca gcccttggtc gtgccagcat gcgccggatg gaagggggat gggaactgaa
2173861 tggttgcctg ctgaactgaa cgctgagcaa attcgatgcc gacgaaacat tatgggtttg
2173921 tttctcgacg gcaacccgtg cgcgattcga cagtcaccgc gatgctgccg acgccggccc
2173981 gcgctcccgg gcgatccgcg tgagcagcgt aatctcgtgc gcacggattt gcggcccgga
2174041 ctagcgcgaa agatactgtt gaacagatgg attcgactgt aacggcctcg atccgacgca
2174101 tgctgggact gctcgccgcc acattgctgc tcggcggctg caccggccag cacacgacac
2174161 gcacagcggc gagcaccaca tacacgcccc acatcaaggc cagcagtcag gacgtactgg
2174221 acggcgccat caatgccgac gagccaggtt gttcggccgc ggtaggagtc gaggggaaag
2174281 ttatctggtc aggcgttcgc ggcattgcgg atctggcatc cggcgccaag atcaccacgg
2174341 acaccgtgtt cgacatcgcg tcggtgtcca agcagttcac cgccaccgcg atcctgctgc
2174401 tcgtcgaagc cggaaagcta acactcgacg acccgatatc ccaatacgta cccgagctac
2174461 ccgactgggc ccaaaccgtc accgtcgagc agctcatgca tcaaaccagc ggcatccctg
2174521 attacgtcgc attgctggca gccagggggt atcaggtcag cgaccgcacc atcgaggccg
2174581 aagcccggca ggcgttagcg gccgcccccg agctgcaatt caagcctggc accaggttcg
2174641 attactccaa ctccaactac ttgctgctcg gcgagattgt ccaccgcgca tcgggacaac
2174701 cgctgcctga gttcctcagc gccgagatct ttcaaccgct tggtctggcc atggtggtgg
2174761 atccggtcgg gaaggttccc aacaaagccg tgtcatatga gaagggcact ggtggaaacc
2174821 ggtccgagta ccgggtgggc aatccggcct gggagcagat cggcgacggt ggcatccaga
2174881 ccacgcctag ccaactggcc cggtgggcgg acaactaccg gacaggaagc gtcggcggcc
2174941 tgaaactgct cgaagcacaa cttgccggtg cggtggaaac cgaacccggt ggcggcgacc
2175001 gctacggcgc cggaatcgtg tcgcgcgccg acggaacact cgaccacgcg ggcgcctggg
2175061 ccggattcgt cacggcattc cacatcagca gtgaccgacg gacttcggtg gccatcagct
2175121 gcaacaccga caagccggac ccggtggcca tggccgatgc gctggggcgc ctttggatgt
2175181 agcggggcta ccgcggttgg ccgccggtac ccaggctgca atcattcacg gtatggcgca
2175241 accaccgtca ctcctcacaa ctgacaatgg cctacccttc ggcgtgcaag gtgcctgcga
2175301 ctcccgtttc accggagtca tccgtgcctt tgctgggctg taccccggcc gcaagttcgg
2175361 gggtggggca ctgtcggttt atatcgacgg tcgccaggtc gtcgatgtct ggacggggtg
2175421 gtccgatcgg cagggcaaag taccctggac ggccgatacc ggggcaatgg tgttctccgc
2175481 gaccaaaggg ttggccgcaa cggtgattca ccgtttggtc gatcgcggcc ttttgtccta
2175541 cgacgcgccg gtcgcggagt actggcccga gttcggagct aacggcaagt ctgaggtcac
2175601 cgtcagcgat gtgttgcgac atcggtccgg actggcgcac ctcaaggggg tggacaagga
2175661 cgaggtcatg gaccacctcc tgatggagca gaagttggcg gctgcgccgc tagaccgcca
2175721 gcacgggaag ttggcttacc atgcggtgac ttacggatgg ctgctgtccg gcttggctcg
2175781 tgcagtgacc ggcaaaggca tgcgtgaact gttccgcgaa gaactcgctc gcccgctgaa
2175841 caccgatggt attcatctcg gccggccacc ggccgactcg cctaccaagg cggcacagac
2175901 acttctgccc caagccaagg tccccacccc actgctcgat ttcatcgcac caaaggttgc
2175961 ggggctgtcg ttctccgggc tgctcggcgc cgtctacttc ccgggcatcc tgtcgttgct
2176021 gcaagacgat atgccgttcc tcgacggtga ggttccggcg gtcaacggcg ttgtgaccgc
2176081 gcgcgccctg gccaagacgt atggggcgtt ggccaatgac ggtgtgatcg acggcacccg
2176141 actgctgtcg tcgcaggcgg tacgtggatt gacggggaag tccgagctat ggccggacct
2176201 taatctcggt cttcctttta cctaccacca gggttaccaa tcgtctccgg tgcctgggct
2176261 gctggagggg tacggccaca tcgggctcgg tggcacgatc ggatgggccg acccggagac
2176321 cggcagcgca ttcggatatg tgcataaccg cttgctgacg ctactgttgt tcgatattgg
2176381 ctcgttcgca gggctggctg cgctgctgaa cagcgccgtc gtggcagcac gtcgcgatga
2176441 ccccctggaa gtgccgcatt tcggtgcgcc ctatagcgaa ccgcgtcatg agcaggcggc
2176501 ctcgggtgca taactgctcc cgttatgccg cgagcgcgag cccgacgggc tagaactcgt
2176561 aaacgagtag ccagacgaga gcgacggccg ccaagaacag accaaccagg atagccgcgc
2176621 gggtaaccag tacctggcga tggaaccact ctcgcagctg ggtgaatcgc cagtcggtcc
2176681 aggcgtaggc gcgcacagcc cactgcgcct cgaccgcgag cagtcgaaac gcgaccagca
2176741 gggccgggat gccgagttcg gggagcagca cgatcatcgg cagggatacg acgaatagcc
2176801 cgccaccgac cacagcgagt gtcgcgcgaa tcagtagcgg cctggcccgt acccgctgtc
2176861 ggtatgcgag cactcgggcg agcgcggcgt cgcgggtgga agtcgggttg atgacgtcgg
2176921 ccgggtccat gactgctcct agtgtgcctg cctcgacgcc tagcggacgg ctgtgtcggg
2176981 ggtggtttgg ttcggactct agtggagccc ggttgcgcac tcgggtccga ccaatgcggg
2177041 gccgcgcctc atacgcacga taagcgtggg tgtatagact gcggttatga atgacggctc
2177101 ccggcaggaa ctcagggttc gtagcggcct actacaaatc gaggactgcc tggatgctga
2177161 cggcggcatc gcattgccgg caggcaccac gctgatctcg ctcatcgagc gcaacatcaa
2177221 gtatgtcggc gacctcgtgg cgtatcgcta cctggaccac gcccgttcgg ccgccggatg
2177281 cgccctggaa gtgacctgga cgcaattcgg tatgcgatta gcggccatag gtgcacacgt
2177341 gcaacggttc gcaggccccg gcgaccgcgt tgcgatcctc gcaccacagg gcatcgacta
2177401 tgtttgcggg ttctacgctg caatcaaggc aggcaccgtc gcggtgccgt tgttcgcacc
2177461 cgaactgccg ggtcacgccg agcgtcttga tacggcactt cgcgattcgg agccagcggt
2177521 catactcacg acggcggcgg cgaaaaacgc cgttgaaggt tttctgaaca acgttccgcg
2177581 cctgcgaaag ccgacagtcc tcgtcatcga tcaaataccc gaccgcgagg gggagctgtt
2177641 cgtcccggtc gagctggaca tcgacgccgt atcccacctg cagtacacct cgggctcgac
2177701 gcgacccccg gtcggtgtcg agatcaccca ccgcgcggtc ggcaccaacc tggtgcaaat
2177761 gatcctgtcg atcgacctgc tcaaccgaaa cacccacggc gtcagttggt taccgctgta
2177821 ccacgacatg ggcctatcca tgatcggctt tccggcggtc tatggcggac actccaccct
2177881 gatgtcgccc acggcgtttg tccgcaggcc actgcgatgg atccaggcgt tgtccgaggg
2177941 gtcgcggacc ggacgcgtgg tcaccgcggc gccaaacttc gcctacgagt gggccgcaca
2178001 gcgtggacta cccgcgcaag gcgacgacgt cgacctcagc aatgtcgtgc tgatcatcgg
2178061 ttccgaacca gtcagcatcg atgcggtgac cacgttcaac aaagcgttcg cgccctatgg
2178121 tttaccgcgt acagcgttca aaccctcgta cggcatagcc gaggcgaccc tgctcgtcgc
2178181 gaccatcgac catgccgctg agccgacggt tgtttatctt gacccagagc agttgggcgc
2178241 cggacacgcg acgcgcgtcg cgccggatgc gcccaacgcc gtcgtgcacg tgtcgtgtgg
2178301 ccatgtggcc cgcagcctgt gggccgtgat cgtcgacccg gataccggcc ccgaggcggg
2178361 cgccgaactg cccgacggtg agatcggtga ggtttggtta caaggcgaca acgttgctcg
2178421 ggggtattgg ggacggccgg aagaaacgcg gatgacgttc ggtgcccgct tgcaatcacc
2178481 gctcgccgaa ggcagccacg ccgacgggtc cgcgatcgac gacacctggc tgcgcaccgg
2178541 agacctcggc gtgtacctcg acggtgagct ctacatcacc ggtcgaatcg cggatctgct
2178601 gaccatcgac ggccgcaacc actatccgca ggacatcgag gccacggccg ccgaggcctc
2178661 gccgatggtg cggcgcggat acataaccgc tttcacggtg ccggccagcg acggggacga
2178721 ccgcaatcag cgactggtga tcatcgccga acgtgcggca ggcaccagtc gcagcgaccc
2178781 gcggccggcg ctcgacgcga ttcgcgcagc ggtttgcaac cgccacgggt tatccgttgc
2178841 ggacctgagt ttcctgccgg ccggcgccat tccacgcacc accagcggga agctggctcg
2178901 ccaggcctgc cgcgcccaat acctcagcgg tcgcctgggc gtgcattagc tacgatctac
2178961 ggctcccaaa tcagcagatc ctccatgccg ttgttcatcg cgacgatggt tggcgatggg
2179021 ccggtgacat cgaagtagat tttgccggtc gattgttcgc cttgggggat agtggctccg
2179081 ctaatggtgt cggggcccgc ggcttgccac agcacccggt agttgatgcc gtcggcggtg
2179141 cgggcattga actgcgagac cgcgggcgtg acgctgccgc gaatcgcatt gaccgtggca
2179201 gtggcctccc agacctggcc ggccaccgga tagccgggga tgactgccgt gctggatttg
2179261 agatcactga ccttccagcc gagcacgact tggccaacgg tgtcggtcat cgttagctca
2179321 ctgccaagtt ttccggtgat gggataggca gccaacgcga ccggtgccgc aaaggtcgcg
2179381 atggccgcca tggccacgac cgctactgcc gtcttgatca ttgtggtgag cttcattggt
2179441 ccctacctcc actacttgtt ggggcgatta cctggttcga acctcgccga cgtcattacc
2179501 ttaagccgca aatgacccgc tgctaactcc agattcgata ggaaccgtgg ggcagacgat
2179561 gccgttcaca tccgtagccg gcgcaccgac gacgggcgtg gccatgaatg cttgatggcc
2179621 gagtcgtagg cgaccagcgc aagggagcca aaccgcatgt caggatggtg tggtgaccgc
2179681 catacccggc ccgtcgggcg ccgaacccgg tgagagccgc gcgctcgcgg gttacccggt
2179741 gacgccgccg gcgctgcccc gcccggtgat cttcgaccag cgctggactg acctgacctt
2179801 catccactgg ccggtgctgc cggagagcgt ggcaggcagc tacccgcccg ggactcgccc
2179861 cgatgtcttc gccgatggga tgacttacgt gggtctggtc ccgtttcgca tgagcagcac
2179921 caaactcggc accgcactgc cgatcccgta tgtcggcacc ttcccggaga ccaatgtccg
2179981 gttgtactcc attgataacg ccggccggca cggggtgctt ttccggtcgc tggaaacagc
2180041 tcgactgact gtcgtaccgc tcacgcggat aggactcggc atcccgtacg cctggtcgag
2180101 gatgcggatg atgcgctctg gtaagcacat tacgtatcac agtgtccgcc gctggccacg
2180161 gcgcggactg cgcagcctat tgacgatcac catcggtgac ctggttgagc cgacgccgct
2180221 ggaagtctgg cttaccgcac ggtggggtgc gcatacccgc aaggctggcc ggacttggtg
2180281 ggtgccgaac gagcataagc cgtggccgtt gcgggccgcg gagatcgccg agttgaacga
2180341 cgagttgatc gacgcaagtg gcgtgcaacc cactggcgat cggttgcgcg ccctgttttc
2180401 accgggtgtg catgcccgat tcggccgtcc gtgtgtcgtt cagtgacgtt taggggcagg
2180461 tgtatccacc atcaatcacg atgtcggaac cggtcatata gctggaagcc tcgctagcca
2180521 gatacaggta gaggccagcg agttcttcgg gccggcccaa ccggcccaac ggaatcttgg
2180581 gctcccatag cggctggtat tccgtgtacg gttcgacgag ctcggtcagg atatagcccg
2180641 gactgacact gttcacccgg attttatgcg gcgccaactc cacggccatg gctttggtta
2180701 gatgaatgac cgccgccttg gaggcgcagt agtgggaaac ctgctgcggg acgttgatga
2180761 tgtggcctga catggaagca gtgttgatga tgaccccgcc ttggccttgt ttgaccatcg
2180821 ccttggcagc ggcctgcgcg gtaaggaaga cgcctgtcac attggtgttt tggaggcgct
2180881 ggaactcttc cagcggcatg tccagcatcg gagtgaccgt gatgatgccg gcgttgcaga
2180941 ccgcgatgtc gatcccaccc agctccgcgg tcacctgatc caacatgctg gtcacctgct
2181001 ggtgctggct cacatcgcag cagacgggca cgaccttgcc acctgatgtg ccaatctcat
2181061 ccgccaactt ctctaaggca tccaaatgcc gtgcggcgat cgccacttga gccccggctt
2181121 cgacgtatgc cagggcaact ctcttgccga tgccggtgga tgccccggtt atcagcgccc
2181181 tcttgccgtg caagtcgaac aggtccaaca cgctcattcg tgatcccctt tcgcgcgacg
2181241 cagggccgat acctgatgga atcacatgcc gaaatgcgtt cgatgaactg ccgcaatggc
2181301 ttccagtggt ccgctcactt cgacccgcgc tacggctcgg cgtccaaaga cgtacagcag
2181361 caactcgccg ggcggtccgg tcaggcgagc cgtcggctcg cctgaccgga ccctcacccg
2181421 cttaccggtt ccaacccact cgatctcaag cccgcaaccg tgcagccgcc gactcaggaa
2181481 gtggctgccg cgccgaacat ttcgccatag ggcagcatcc atttcgggcg tgaggcttcg
2181541 gggccctcgt ccgctggcgc ggcgaacgtc ctcgtgatgg acaaagaatt cgttgaggtt
2181601 cgccaaggta cgaacccatc cgatgcggaa gaaccccatc ggtggaccgg accgaatccg
2181661 agcgacgagc cacgtgaagt ctttactctg agccaatctc gctctacggc gttcggcaaa
2181721 ccgctggaag ggacccggta gaacgatgca aaggccagca acgagatcgc gttcacgcag
2181781 cacgatgtga gcggccaggt cgtgagcagt ccagccctcg atcagtgtag caaccgcagg
2181841 accgagctcc tcaaggagat cacagagctc caagcgttct tgcgcgtcca acgggacatc
2181901 agccacgccg cgggagtcta cgggcgacgt gcctgcgcgc caacgggctg ccgcttgcgc
2181961 cgtcgcgact gcacagcagc cagcgcccgc tcccaggcga gcagcgttgc ggccgtcaga
2182021 ttggccggtt tggcgctgtc cttggacagc agcgcggtcg cggcggcttt ggtggtcggc
2182081 gacgccttcg acatgtgacc ggagtcgaac ggcggctgcg ggtcgtactc gatcgccagc
2182141 tgaatcgcct tggcccgggc ctccccgccc agctgtccgg ccagccagag ggcgagatcg
2182201 agcccggcgg acacgcccgc gctcgtgaca atgttgtcct ggtgcacaat ccgctcgtcg
2182261 gcgaccggga tagcgccgaa tgccttgagc gcgggaagcg tcagccaatg cgaggtcgcg
2182321 cgccggcccc ggagccacac gaaccgcacc tgggcgtgcg gcaggtttcg cagcacctcg
2182381 tacgggccga ccacgtccag cgcggtaacg ccggggtagg ccacgaatgc gatttgcgtc
2182441 atcggtgttc tccctagtgt caggcgaagg ctttgcggta ttggtcgggt gatatcccga
2182501 cgcggcgaat gaagctgcgg cgcatggttt ccgcggtccc gaagccgcat cgggcggcaa
2182561 ttgccaccac ggtgtcgtgg gtctcctcca actggcggcg cgcagcctcg gtgcggatgc
2182621 gttcgacgta ccggccgggc gcctcgccga cctcgtcgct gaacacccga gtgaaatgac
2182681 gcgggctcat ggccgcacgt tgagccagtt cgccgatgcg gtgcgcgccc ccggctcggc
2182741 ctcgatggcc tcctgcaccc ggcggatcga ggtccgtttg gcgcgtggca tccacaccgg
2182801 agccgcgaac tgggtctgcc caccgggtcg gcgcagatac aggacgagcc agcgggcaac
2182861 cgtctgggca atctcggtgc cgtggtcgtc ttcgaccagt gccagcgcga ggtcgatgcc
2182921 ggcggtgact ccagccgcgg tccacacctt ctgcgaactg cgcatgaaga tcgggtcggc
2182981 atcgacccga acggccggaa attcgcgggc gaaatgttcg gcaaaggccc agtgcgtcgt
2183041 cgctcggtgt ccgtcccaac aaccccgctt cggccgcaag aaacgcgccc gtgcacacgg
2183101 tgacgacgcg gcgggcggtg ccggagacgg ctttgaccca gtcgatgagg gccggttcgg
2183161 accgtgcggc atcgactccg gcgccaccgg gcaggatcac ggtgtcgacg gggtcgccgg
2183221 ggaatcccac gataaccact cttcgcgcca tgaatgccag tgttggccag gcgctggcct
2183281 ggcgtccacg ccacacaccg cacagattag gacacgccgg cggcgcagcc ctgcccgaaa
2183341 gaccgtgcac cggtcttggc agactgtgcc catggcacag ataaccctgc gaggaaacgc
2183401 gatcaatacc gtcggtgagc tacctgctgt cggatccccg gccccggcct tcaccctgac
2183461 cgggggcgat ctgggggtga tcagcagcga ccagttccgg ggtaagtccg tgttgctgaa
2183521 catctttcca tccgtggaca caccggtgtg cgcgacgagt gtgcgaacct tcgacgagcg
2183581 tgcggcggca agtggcgcta ccgtgctgtg tgtctcgaag gatctgccgt tcgcccagaa
2183641 gcgcttctgc ggcgccgagg gcaccgaaaa cgtcatgccc gcgtcggcat tccgggacag
2183701 cttcggcgag gattacggcg tgaccatcgc cgacgggccg atggccgggc tgctcgcccg
2183761 cgcaatcgtg gtgatcggcg cggacggcaa cgtcgcctac acggaattgg tgccggaaat
2183821 cgcgcaagaa cccaactacg aagcggcgct ggccgcgctg ggcgcctagg ctttcacaag
2183881 ccccgcgcgt tcggcgagca gcgcacgatt tcgagcgctg ctcccgaaaa gcgcctcggt
2183941 ggtcttggcc cggcggtaat acaggtgcag gtcgtgctcc cacgtgaagg cgatggcacc
2184001 gtggatctga agagcggagc cggcgcataa cacaaaggtt tccgcggtct gcgccttcgc
2184061 cagcggcgcg accgtctgga gttcgtcacc gttggccgcg ctcatcgcgg cgaacatcac
2184121 cgtcgcccgg gtggcgtcga tctcgatcat catgtcggcg caggcgtgct tgaccgcctg
2184181 gaaggaaccg atcggtcgat cgaattgcgt tcgccgcccg gcgtattgca ccgccaggtc
2184241 gaggcaggcc tcggcgccgc ccagcatctc ggcggccaac agcacccggg ccacgtcgag
2184301 cacccgctcc atatcgtcgg gcgtcccggc ggtcagcggc tcggcggggg accccgccag
2184361 ccggagcgtg gcgaccggac gggtgatgtc aaacgagggc aacggtgtga cggtcacccc
2184421 gggggcgtcg gcggccacga cgtgcagaac gatcgacccg tcggccaccg cgggcaccac
2184481 gaacaggtct gcgacgtgac cgtgcagcac cggggtgcac tcgccggtga gtgcgggccg
2184541 accgtcgcgc cgaacggccc gaacggtggt agccgacgcg acgtcgtggc cactgacggc
2184601 gatcgttccg atccgcgcgc cggtaagcag accggcgagc aggcgcttgc gctgctcgtc
2184661 gtcgcccatg cgcagaatcg cttcgatcgc aaacaccgtg gccgcaaagg gaattggggt
2184721 gagcgcccgg ccgagttcgg caaacgcgat cgcggtctcg actaaggtgg cacccaatcc
2184781 gccgtgctcc ggcgggacgt gcagcgcggg taattcgagc tcggtgcaaa gccgttgcca
2184841 cagcctgcgg tcggatccgt ccgcggcagc catctcccgc acgggcgcgc cccggccaag
2184901 gaagccgcgc agcgaggcgc ggaaatcgtc ttgttcggtg ctgtatcgga agtccacgtc
2184961 agcagagcac ttcgggccgc ggctccttgg ggaggccgag cagccgctcg ccgatcacgt
2185021 tgcgctggat ctgcgagctg ccggcataga tcgtcgcggc ccgtgcgtag agcagctcat
2185081 ccatccagca ggccggggag tttggcgtac ccgcctccgg gaccagccgc gcaccgccgt
2185141 tgccgggccc ccgcgggccc agcgcctcga gccccaggat ttcgacggcg agatcggtgt
2185201 accggcggaa atattcgctc cagatgacct tcgtgatcgc ggcttccgcg ccgggcggcc
2185261 gtccggtcag ggccagggtg aggtcacggt agccccgata ccgcatgatc tgaacccggg
2185321 catagcacca cgccaagccg tctcgtaccc gtggatcggt gtgtaatccg cggtcacggg
2185381 ccagctcgca cagccgctgc aggtcccgct caaaatcgat ggcggcggtg gcgatgtgcg
2185441 atccgcgttc gaagccgagc agcgtcatgg cggtcgacca gccgtcgccg acccggccga
2185501 cgacattgcc ggcgctggtg cgggcatcgg tcaggaagac ctcgctgaac gaggagtgcc
2185561 cggccgcgtt gacgatcggc cggaccacga cgccgggctg gtccatgggc accagcagaa
2185621 acgacaggcc ccggtgtttc gcagcgctgg gatcggtccg cgccagcagg aagatccagt
2185681 ttgcggtggt gccggccgac gtccagattt tgtggccgtt gatcacccat tcgtcaccgt
2185741 cgagcacccc cctggtgcgc accgaggcca ggtcggagcc ggcctccggc tcggagaagc
2185801 cctggcacca ccgatgctcg ccgctgagga tgcgcggcag gaaatgccgc ttctgcgcct
2185861 cggaacccag ggcgatcagg gtgttgccca gcaggtcgat tccgagcagg tcgttttccg
2185921 cgcgttcggg cgcgccggcg cgggcgaatt cctcggcgag caccacttgt tccatcgggg
2185981 acaggccacc acccccgtat tccgtcggcc aggacaccgc gaccaggcca gcgccggcca
2186041 gggcccgccg ccagtgccgg gcgaactctt cccgctcgtg gggcggcagc gccccgggtc
2186101 cgggccaccc gggcggcagg tgctcggcca caaactcccg gatccggtcg cggaacgctt
2186161 ccgcttcggg tgggtagctg acgtccactg cgcgccccgg cctcagggcc gctgcttgat
2186221 cgcgggccgg atctgcggtg cggcgcgcca gtcctccagg ccgtactcga ccgttccgta
2186281 ggacagcttg ccgccggtga cttcgcccca gtgcgcgtga ttgagctggt ggatcttgaa
2186341 gcaaccgtcc agcgcggcgg aaaaccccat ggcatcgacg gtttggttca ccgattcctt
2186401 gatcagcagt gccgccatcg tcggcacctt cgcgatccga cgcgcgaatt cgattgtgct
2186461 ggtcgcgagt tcgtcagcgg gaaacacctt gctgaccatc cccagcgcgt gggcctcgtc
2186521 ggcgcctatg cagtcgccgg tgagcagcag ttccttggtc ttgcgcggcc cgaactccca
2186581 cggatgtccg aagtactcga ccccgcacat gcccagccgg gtgccgacca catcggcgaa
2186641 cacggtgtcc tcgctggcga cgatcagatc gcagcaccag gccagcatca accccgccga
2186701 cagcacggcc ccgtgcacct gggcgatggt gatcttgcgc aggttgcgcc accgcttggt
2186761 gttttcgaag tagtagtgcc actcctggcg gttgcgtgac tcgaccccgc cgaaggtcgc
2186821 cccgttgcac cggtagctgg ggtgctggtc cggcccgggc gagcgttccc ggatatcgtc
2186881 agcggatccg aggtcgtgac cggcggagaa ggcggggccg gcggcccgca ggatcaccac
2186941 ccggacggtg tcgtccgcct cggcaagttc gaaggcggcg cccagctcga ccagcatgcc
2187001 gcgggtctgg gcgttgcgtt gtttcgggcg gtccagggtg atcgcggcga tgcgcccatc
2187061 gtcgatggtt tcgtagcgga tgtattcgaa ctcccggggc cgtcgggagc gttccccgtc
2187121 cgaccggcga tcgaccggac cgaccctgcc gacgaacatg tccgctcctt actggacgtg
2187181 aacggctgac ctgtgcgagg ttacccgtcc cttagccaac atgtccatag ccaatacgca
2187241 catgagagtg atcgatatag acaaattccc atgcaaagaa gcacttgtgt acaacgaagt
2187301 atcttggtag tactgtgata tacgcaaagg gcgccaccgc agcgcgccgg gcatccgacc
2187361 ggtacaacca ggaagggttg acgatggaga tcggaatatt cctcatgccg gcccatccac
2187421 cggagcgcac cctctacgac gccacccggt gggatctgga cgtcatcgag ctggccgatc
2187481 aactcggcta cgtggaggcc tgggtcggcg aacacttcac cgtgccgtgg gagccgatct
2187541 gcgcccccga tctgctgttg gcgcaggcgc tgctgcgcac ccaacagatc aagctcgccc
2187601 cgggtgcgca cttgttgccc taccatcatc cggtcgagtt ggcccaccgg gtggcctatt
2187661 tcgaccacct cgcccagggt cggttcatgc tcggcgtggg cgccagcggc atcccgggtg
2187721 actgggcgct gtatgacgtg gacggcaaga acggcgagca tcgcgaaatg acccgggaag
2187781 cgctggagat catgctgcgc atctggaccg aggacgagcc ctgggagcat cgcggaaagt
2187841 actggaacgc caacggaatc gcgccgatgt tcgagggtct gatgaggcgc cacatcaagc
2187901 cgtaccagaa gccccacccg cccatcggcg tcaccgggtt cagcgccggc tcggagaccc
2187961 tcaagctcgc cggcgaacgg ggttacatcc ccatgagtct ggacctcaac accgaatacg
2188021 tcgccaccca ctgggacgcg gtggaggaag gcgcgctgcg cagcgggcga accccggatc
2188081 gccgcgattg gcggctggtg cgggaggtgc tggtggccga gaccgatgag caggcgttcc
2188141 ggtatgccgt ggacggcacg atgggacgcg ccatgcgtga gtatgtgctg ccgacgtttc
2188201 ggatgttcgg catgaccaag ttctacaaac acaatccgtc ggtgcccgac gacgaggtga
2188261 caccggagta tctcgccgag aacaccttcg tggtcggctc ggtgcagacc gtggtcgaca
2188321 agctcgaggc cacctacgac caggtcggcg ggttcggcca cctgctgatc ctcgggttcg
2188381 actacagcga taacccgggc ccgtggaagg agtcgttgcg gctgctggcc cacgaggtca
2188441 tgcccagact caacgcccgc ctcgccacca agcccgccac cgcggtggtg tagccatggc
2188501 ggttcgtcag gtcaccgtcg gctattcgga cggcacgcac aagacgatgc cggtgcggtg
2188561 cgaccagacg gtcctggatg ccgccgagga acacggcgtg gccatcgtca acgaatgcca
2188621 aagcgggata tgtggcacct gcgtggccac ctgcaccgcc ggccgctacc agatgggacg
2188681 caccgaggga ctgtccgatg tcgagcgggc ggcgcgaaag atcctcacct gccagacgtt
2188741 tgttacctcc gattgccgga tcgagctgca gtatccggtc gacgacaacg ccgccctgct
2188801 ggtcaccggt gacggtgtgg tgaccgcggt cgagttggtg tcgcccagca ccgccatcct
2188861 gcgggtggac acctctggca tggccggcgc gctgagatac cgggccggcc agttcgccca
2188921 attgcaggtt cccggtacca acgtatggcg caactactcc tacgcccatc cggccgacgg
2188981 ccgcggtgag tgcgagttca tcatcaggtt gctgccggac ggcgtgatgt cgaattatct
2189041 tcgcgaccgc gcccagcccg gtgaccatat cgcgctgcgc tgcagcaagg gcagctttta
2189101 tctgcgcccg atcgtgcgac cggtgatcct ggtcgccgga ggaaccggcc tgtcagcgat
2189161 cctggcgatg gcccagagcc tggatgccga tgtcgctcac ccggtctacc tgctctacgg
2189221 ggtcgagcgc accgaagacc tgtgcaagct cgacgaactc accgagctgc gccgccgcgt
2189281 tggccgcctg gaggtgcacg tcgtcgtcgc tcgcccggac cccgactggg atgggcgcac
2189341 cgggctggtc accgacctgc tcgacgagcg gatgctggcg agcggtgacg ccgacgtgta
2189401 tctgtgcggt ccggtcgcca tggtcgacgc agcccgaacc tggctggacc acaatggctt
2189461 tcaccgtgtc gggttgtact acgagaagtt cgtggccagc ggggcggcgc gccgccgcac
2189521 cccggctcgg ctggattacg cgggcgtgga cattgccgag gtgtgccgcc gcggccgcgg
2189581 caccgcggtg gtcatcggcg gcagcatcgc gggcatcgcg gcggcgaaaa tgctcagcga
2189641 gaccttcgat cgcgtcatcg tgctggagaa ggacggcccg caccgtcgcc gcgagggcag
2189701 gccgggcgcg gcacagggtt ggcacctgca ccacctgctg accgccgggc agatcgagct
2189761 ggagcgcatc ttccctggca tcgtcgacga catggtgcgc gagggagcgt tcaaggtcga
2189821 catggccgcg cagtaccgta tccggctggg cggcacctgg aagaagcccg gcactagtga
2189881 catcgagatc gtctgcgcgg gaaggccgct gctcgaatgg tgtgtgcgcc gccggctcga
2189941 cgacgaaccg cgcatcgact tccgctacga atcggaggtg gccgatctcg ccttcgaccg
2190001 cgccaacaat gccatcgtcg gcgtcgccgt ggacaatggc gacgccgacg gaggcgacgg
2190061 tttgcaggtg gtgcccgccg agttcgtcgt ggacgcgtcg ggcaagaaca cccgcgtgcc
2190121 ggagttcttg gagcgtctcg gtgttggcgc tcccgaggcc gagcaggaca tcatcaactg
2190181 cttctactcc acgatgcagc accgggttcc gccggagcgg cggtggcagg acaaggtgat
2190241 ggtgatctgc tatgcgtacc gccctttcga ggatacctac gccgcgcagt actacaccga
2190301 cagctcccgc accatcctgt ccacctcact ggtggcctac aactgctatt cgccgccgcg
2190361 taccgcccga gaattccgcg cgttcgccga cctgatgccg tccccggtca tcggggagaa
2190421 catcgacggg ctggagccgg catcgcccat ctacaatttc cgctatccca acatgctgcg
2190481 gctgcgctac gagaagaagc gcaacctgcc gcgggctttg ctggcggtgg gcgatgccta
2190541 caccagcgcc gacccggtgt cgggtctggg tatgagcctg gcgctcaagg aagttcggga
2190601 gatgcaggcg ctgctggcta aatacggcgc cggtcaccgg gatctgccgc gccggtacta
2190661 ccgggcgatc gccaagatgg ccgacacggc ctggttcgtg atccgcgagc agaacctgcg
2190721 cttcgactgg atgaaggacg tcgacaagaa gcgcccgttc tatttcggtg tgctgacctg
2190781 gtacatggac cgcgtgctgg agctggtgca tgacgatctc gacgcgtacc gggaattctt
2190841 ggccgtcgtc catctggtca agccgccgtc ggcgctgatg cgacccagga tcgccagccg
2190901 cgtcctcggc aaatgggcac gaacccgatt gtcgggccag aagacgttga ttgcccgcaa
2190961 ctacgaaaat catccgatac cagccgaacc cgcggaccaa cttgtaaacg cttaggagag
2191021 cccaacgtgt cgcaggtcca tcgaatcctg aactgccggg gcacccgcat ccatgccgtg
2191081 gcggacagcc cacccgacca acagggaccg ttggtggtgt tgctgcacgg gtttccggag
2191141 tcctggtact cgtggcggca tcagattccc gcgcttgccg gcgcgggcta ccgcgtggtg
2191201 gccatcgacc agcgcgggta tggccgctcg tcgaaatacc gggtgcaaaa ggcctaccgc
2191261 atcaaggaat tggttggcga cgtcgtgggc gtcctcgact cctatggtgc ggagcaggct
2191321 ttcgtggtgg gccacgactg gggtgcgccg gtcgcctgga ccttcgcctg gctgcacccc
2191381 gaccgatgcg ccggcgtggt gggaatcagc gttccgtttg ccggtcgcgg cgtgatcggc
2191441 ctgccgggca gcccgttcgg cgagcgccgt cccagcgact accacctgga gctggccggg
2191501 cccggaaggg tctggtatca ggactatttc gccgtgcagg acggcatcat caccgagatc
2191561 gaggaagact tgcggggctg gctgctcggg ttgacctaca ccgtttccgg tgaggggatg
2191621 atggcggcga ccaaggcggc cgtcgacgcg ggcgtcgacc tggagtccat ggacccgatc
2191681 gacgtgatcc gtgccggacc gctgtgtatg gccgaaggcg cgcggctcaa ggacgcgttc
2191741 gtctacccgg agaccatgcc ggcctggttc accgaggccg atctcgattt ctacactggc
2191801 gaattcgaac gttccgggtt cggcgggccg ctgagcttct accacaacat cgacaacgac
2191861 tggcacgacc tggccgacca gcaaggcaag ccgctcaccc cgccggctct gttcatcggc
2191921 ggccagtatg acgtcggcac catctggggc gcgcaggcca tcgagcgtgc gcacgaagtc
2191981 atgccgaact accgcggcac ccacatgatc gccgacgtcg gacactggat ccagcaggaa
2192041 gcgcccgaag agaccaaccg gctgttgctc gacttcctag gcgggctgcg gccgtgagct
2192101 gcaccttcga catggtcccg gagaccgtcg atcatctcga cgaggtcggg ctgcggcggg
2192161 tcttcggctg ctttccgtgc ggcgtgatcg ccgtctgcgc gatggtcgac gaccagccgg
2192221 tcggcatggc ggccagctcg ttcacgtcgg tttcagttga cccgccgctg gtatcgatct
2192281 gtgtgcagaa ctgttcgacg acgtggccga agttgcgcga ccgcccacgg ctcggtgtga
2192341 gcgtgctcgc cgaggggcac gacgcggcct gtatgagcct gtcgcgcaag gaaggtaacc
2192401 ggttcgccgg ggtgttctgg agcgaattgt ccagcggggg tgtggtgatc gccggggccg
2192461 gcgcctggct ggattgccgc ccgtacgcgg agatcccggc gggggatcac ctgatcgccc
2192521 tgctggagat ctgcgcggtg cgcgccgatc ccgagacacc gccgctggtg tttcacggta
2192581 gccggttccg ccggttggag tctcgatgaa gacgaccgat gtgcgggtac gtcgtgcgat
2192641 cacggcgatg gcgggcggtc acgccgtggt cctgaccggc gaccccaatg gcgatggcta
2192701 tctcgtcttc gccgcccagg ccgcgacgcc gcggctggtt gcctttgcgg tccggcacac
2192761 ctcgggttat ttgcgcgtcg cgctgccggg cgccgaatgc gagcgactgc acctgccgcc
2192821 catgtgtgac cgagacacca cgcattgcgt gtcggtcgac gttcgcggca ccggcaccgg
2192881 aatctcggcg agcgatcgcg cctggaccat cgcggcactg gcttcggcca cctccgtcgc
2192941 cgccgatttc caacgtccgg gccatgtggt gcccgtgcag gcgcaagccg acggtgtgct
2193001 gggtcggcgg ggacccgccg aggcggccgt cgacctggcc cgcctggcgg aacggcggcc
2193061 ggccgccgcg ctctgcgaga tcgtctcgcc cgataatccc gtccagatgg cgcaccacgc
2193121 cgagtcggtc gaattcgccg tcgaacacgg actggccatg gtctcgatcg gggagctggt
2193181 ggcgtatcgc cggcggatcg agccccaggt ggtccggttt acggcagcga cgctgcccac
2193241 ctgggccggc gcctcgcgtg tcatcggctt tcgtgacgtt tacgacctcg gcgagcattt
2193301 ggcggtcatc gtgggtgcgg tcggtgccgg ggtgcccgtg ccgctgcacg tccacatcga
2193361 gtgcctgacg ggcgacgtgt tcggctcgac ggcgtgccgc tgcggcgagg aactcaacgg
2193421 cgcgctggcg aggatgtcgg ctcagggcag cggcgtggtc ttgtatctgc gtccgcccgg
2193481 acccgcgcaa gcgtgcggct tgttcgcccg gggcgatgcg gcgaccgatg tcatgccgga
2193541 gaccgtgaca tggatcctgc gcgatcttgg ggtgtatgcg atccgacttt ccgatgatgt
2193601 gccaggattt gggcttgtca tgttcggggc gatccgagaa gccagcacgt tggcggccgc
2193661 aggttgaacc atccagacct ggccggcaag gtcgcgatcg ttactggggc gggcgccgga
2193721 atcggtctgg cggttgcccg gcgactcgcc gacgagggct gccatgtgct gtgcgcggac
2193781 atcgatggtg atgccgcgga tgccgcggcc accaaaatcg gttgtggcgc agcggcctgc
2193841 cgggttgacg tcagcgacga acaacagatc atcgccatgg tcgacgcctg tgttgccgcg
2193901 ttcggcgggg tggacaagtt ggtcgccaac gccggtgtcg ttcatctggc ttcgctcatc
2193961 gacaccaccg tcgaggactt cgatcgggtc atcgcgatca atctccgcgg cgcctggctg
2194021 tgcaccaagc atgcggcacc gcggatgatc gagcgcggcg ggggagccat tgtcaacctg
2194081 tcgtcgttag cgggccaggt agcggtgggc ggcaccggcg catacggcat gtcgaaggcc
2194141 ggcatcatcc agctcagccg catcaccgcc gccgaactgc gctcgtcggg catccgctcc
2194201 aacacgctgc tgcccgcatt cgtcgacacc ccgatgcagc agaccgccat ggcaatgttc
2194261 gacggggccc tgggcgcggg gggtgcgcgc tcgatgattg cccggctgca gggccgcatg
2194321 gccgcaccgg aggagatggc cggcatcgtg gtgttcctgc tgtccgacga tgcgtcgatg
2194381 atcaccggca ccacccagat cgccgacggc gggacgattg ccgcgctgtg gtgatcccct
2194441 cgggtcaggc ggtttcgaaa gatcacgcga gacattgcct gcgacggcat gctacatatg
2194501 tgattccggt gtattcgggc ctctgcgcat tgctttcgat cacaatgagc ttggccgcga
2194561 gccgtcttgt tcgttgagcc acggggccgt tcgaatgcgt tcgtcagaac tccggctcgg
2194621 attctcgcta gtttgctgac gtgtcatcga gagcaatcga cggcgacctc gagggccgtg
2194681 cagatggcgc gcatccggat gtcggcgagg cggccaagcc gattcaccaa taccgcgacc
2194741 gagacacttt cgactgagtc caaattcacc gcggaacggc gcgggatcgg gtcggaaccg
2194801 ggttcaagaa caacctcact ggctagccct cggatggtcg tggtgcaggg cgcgacaagt
2194861 gcgcgtcgca gccgagggat cgcggcatcg cgcgacagca cgacgactgg tcgccgaccg
2194921 atctcagcca tctcacacca ccacacctct ccgcgcgccg gaagtgcggt cacgagtctc
2194981 cagccgcccg ccgccacgac gctagatcgc cccactcgtc gggctcatcg accgggtgct
2195041 tgtcgtaggc cgcatagctg gcatccacct cggccgatcg atgacgagcc agtaatgccg
2195101 caagggcctc atcgatgagg gctgcgtcag tgattcctgc ccgcatgtcg cgcgcacttg
2195161 tcaagagtgc ggcgtcgaca gtagtgctca gccgtatgcg attcatgcca ctactatgcc
2195221 acactccggg gcgtggatcc gcctgatcgg acgcaacgtg ctcgatacgg gcgaaacatt
2195281 ggtcgctgga cgaattgatg aggtctaccg cgcagcgcaa cgtcacctgc aaccgggccg
2195341 tcttcacggt gcgggttccg tgtcgatgaa cgacgctgcg gcacaacact ttttgtactt
2195401 gtgccccgag ccgcaccagc actgttggtt gcggcccggt ggccaggcca tcacatcgtg
2195461 gtcaccgtgt gctgtcaggt acgcggcata ctcggcgcgg gcctccggcg agtccggctc
2195521 ctgaccctgt tcggcgcacc aggcagcgaa gggtgccacg cggatcgcgg cgaccgccag
2195581 tcctgggaaa ccagcctcgg cgaattcgac cagcttttgc tgcatcctcc ggcagtacag
2195641 cgggtgcgcc accggcccgt ccggaccggt caccaggtcg ctgccggcga agtctggcca
2195701 caggtcgagc gcccgctcgt agtcaccggc aggcagccac gccaatgaca ccgcggtgat
2195761 cggttcggcg gattccgccg cgggtgtctc atcgacggga ggcacccggc tggctccgtt
2195821 gtcactcatg gtccaacatc ctgccgcatc accaccgcac gcggcatatg atgctcgcag
2195881 tcgcggtggt gcggccttat cgccatgagc gaaatcttct gtatcactga tcattccgag
2195941 cctatgacgg cccggttctt gtcagtggtg cttcgtagaa tccgaggcat gaggtcggac
2196001 acgcgcgagg agatctccgc ggcgttggat gcctaccacg cctcgttgtc gcgggtgctc
2196061 gatctcaagt gcgatgcgtt gaccaccccg gaattgctgg cctgtttgca gcgactcgag
2196121 gtcgaacggc gccgccaggg cgccgccgag cacgccttga tcaaccaact cgctgggcaa
2196181 gcctgcgagg aagagctcgg cgggacgctg cgcacggcgt tggccaaccg gctacacatc
2196241 actcccggtg aggccagccg ccgcatcgcc gaagccgaag acctcggtga gcgccgcgcc
2196301 ctgaccggtg aaccgctgcc agcgcagttg accgcgaccg cggccgctca acgtgagggc
2196361 aagatcggcc gagaacacat taaggagatc caggccttct tcaaggagtt gtccgccgcg
2196421 gtggatctgg gtatccgcga ggccgccgag gcccagctgg ccgaactggc caccagtcgg
2196481 cgtcccgatc acctgcatgg cctggccacg cagctgatgg actggctgca ccccgacggc
2196541 aacttttccg accaggagcg tgcccgcaag cgcggcatca cgatgggtaa gcaggaattt
2196601 gacgggatgt cacgtatcag cggtctgctg accccggagt tgcgggccac catcgaggcg
2196661 gtgttggcca aactggccgc accgggggcg tgcaaccccg atgaccagac cccggtcgtg
2196721 gatgacacac cggatgcgga cgcggtgcgc cgcgacaccc gcagccaagc ccaacgacac
2196781 catgacggtt tactggccgg gctgcgcggg ttgttggcct ccggtgagct agggcagcat
2196841 cgggggttgc cggtgaccgt cgtggtgagc accacgctta aagagctgga agccgccacc
2196901 ggcaaggggg taaccggtgg tggttcgcgg gtgccgatgt cggaccttat ccggatggcg
2196961 agcaacgcgc accactatct ggcattgttt gacggcgcta agccgttggc gttgtatcac
2197021 accaagcggt tagcttcccc ggcgcagcga atcatgttgt acgccaagga tcgtggctgc
2197081 tccaggccgg gttgcgacgc cccggcctac cacagtgagg tccaccacgt aacgccgtgg
2197141 acaaccaccc accgtaccga catcaacgac ctcacgctgg cctgcggccc cgacaatcgc
2197201 cttgtcgaaa aaggctggaa aacccgcaag aacgccaaag gcgacactga atggctaccg
2197261 ccggcccact tggaccatgg ccaaccacgc atcaatcgat accaccaccc cgagaaaatc
2197321 ctgtgcgaac ccgacgacga cgaaccacat tgacacccaa tgaccgtggc attgccggtc
2197381 acgtcgcaac caagtactgc gaccgtagcc gcgctcaagg ctcggggtag acgagcgcgg
2197441 agagaggcac gttgccgagc tgcctgccga cgacgagtat cccaatatcg tgctcaccca
2197501 tagcgtttca gcgggcaacc aacgattgcc ggccagcgaa tctcggtggc ggtagccagc
2197561 atgaaggacg cagatgacct cgccgactac gggctgagca tagagcaggt gcgtgcagcc
2197621 gtcgactcgc atgtggacgt ggaccattct gtctcagcgc tgtgaccgca cggtagagtt
2197681 cgccatcgtg gctgacgatg acgtcaccgg tcaggatggc tccggcgacg gcaccgatcc
2197741 gcgcaccatg ctgggccggt ttgccaacca gcacaacgaa tgggtgcgcc tgagcgtgcg
2197801 ccacgtgctc gatgcgggcg aagcattgga tgccggacag attgattagg tctaccgcca
2197861 ctttcggcag gaaaaggcac tggacacacg ccaccgagcc ggccgtacca ccgttgacac
2197921 tcggcatcag caacccggaa acagccgaac ccctgatcat ctggccgacc tcgcccctgg
2197981 ccgcaccgcg accatcgggc tgcgggattc cagctgcctg cgcgtggacc gctacaacga
2198041 ccaggcgtcc gggcgagcgc tcatcgagat ccggttgtgc aacgaacgtg ccacgccgat
2198101 gccaatcccg atcgggctgt ggatgtttca gaccaagctc cacgtcaacg ccggcggcgc
2198161 tgacgtgttc ctgccggtct gcgacgtgct ggagcaagac ctcgccgagc gcgacgagga
2198221 ggtacgccag ctgaacctgc agtaccgcaa ccggttggag tatgcgatcg ggcggacttg
2198281 ctcggcggcc tggtcggtga acggctcgcg gcgcccgtcg gcagtgtgga ccacctggct
2198341 gccggtcgcc gaaacacccc acacccgggc ccggtcggtg gagaacgcgc tgttgtccat
2198401 ggacagtcgc ggaggggtta cgtagcggac tggcgtcgtt cgtcgcggga tatggaagct
2198461 ggtttcaggg tcaggcggct gtcgcggccg agctgcccga gcacctgcac ccgaccgccg
2198521 acgagaggct ggctcatgtt gcggccgaaa aggaagcgct gcgctgcttc cagttcatga
2198581 accaggtgat gcgcgatcac cgtaaaagct tgtcagaggt gcagtgaaca ctgtttccat
2198641 gaccaagagc aacgggcact gttgagacac agcgcgtcgc caacgggcgc tgcctgtggc
2198701 cgaacatcgt aaatcaagca tattcgtcaa cagatatcat caatgtcggc gccggactat
2198761 tcaaatcatc gatatactgg tggcctggtc cttcgccatc gatcaatggc gatagcttat
2198821 cgaggatttc taccaacttc gtgtcatcga agcgccatac aacggtttgc gatcccagtt
2198881 ccatatccgc agttccgctt tctcgaacta tccgttgctg tacaccatct atgtcgaaag
2198941 ttgcctgacc actctcatgg gccgatcgca cggcgtactg gaaaatgcga agcccatccc
2199001 ggtctgcggc cgccagaacc acgtcaccga agtagttatc cggcttgata ccgaaaacgg
2199061 tcattctggt ccaatcactt gtgagtcgga aggtccccga tgggaatatt ctgccacctg
2199121 gcggtcggcg aatcgtgggg gttgtaatcc caatgcggat agcggtaatt gtctcccgga
2199181 aaatatcgcc actcgccgcc gttctcgtcc cagaggcttt cgccgccgcg agcctgttgg
2199241 ataggacgac tgggcggtcc aaccgttagg ttgctctcgg cgggcgggct gacaccgggc
2199301 ggaggtaagc cttcgttcgg ttgtggtcca gcggggtcgg gagcaggagg gggttcgcct
2199361 tcgaccggca cgcccaattc gcctaaccgg gctctgattg cggcttgtct ttcaaagaga
2199421 gaacccttgt ccgcgatgca cgcgtcgtag gctgcctgct cgttgggcag aacgaaggtg
2199481 cgtccgcatc gggcgttgta ccgagcgatg tcagcgttga cggcgtccca ggctgcgcgt
2199541 gcctgtacgg ctgtcatgtc tttcgggtcg cccggcatcg gtgagggtgg atcttgtttc
2199601 cagctgcggt cgaccgcgtg gatttgcggt ttctcgttgt ggggcaccgg tgtcggtagc
2199661 gacggtgcga ttgggggttc gtggaagccg acggtgttaa ggggtgcggt agcggtggct
2199721 attttggcgg ccacttcgtg ttcgactccg atgagttgtg tcgcgcgttg gcggatatcc
2199781 ccggccaatg cttgtgcttg ggcctggcga gctgcttgtt cggcgaaggt gcggctggtt
2199841 cgggtgtcgg tgaccgagag gtcctcttcg acgttgaagc ccgcgttgtg ggcatcttga
2199901 acggcataga tgaccctgcg ctgggctgcg ccgatggttc cggcgccttc acgggcaagc
2199961 ccactcgctt ggcgcaaatg ctcggctatg ccactgacta tctgtaggtc agcgccggtt
2200021 cgctgtcgca gccatcaccg cctgcgcctt cccacgcgat gaagtgggat cggttacgca
2200081 tctctaggaa cacgtcttcc cactgatcgg cgaccttcgt ccagtagtag gccgcctcga
2200141 tgagatgttc ggtgtcccag gcgtggatat gcgacagggt cggcagcaat tacaccagcc
2200201 tcgtttgcgg cacggccgcc atctcggccg ctgcggccgc ctcgttgttg gcatactccg
2200261 ccgcggccgc ctcgaccgca ctggccgtgg cgtgtgtccg ggcggtaaac gccgccacgg
2200321 caagaccaac cgctgcgtgg gcaccgccca cagccgccgt ggtgggttgg aacggctgcc
2200381 ccagcggagg tggtgcaagg acgctgagtt cagtgcttcg cccgctccat tggctggccg
2200441 tagccgctac ctgttggata ttgacccgca gctcaccggc tttcatcctc ggaaagttta
2200501 atagcgagct acagggtggc aactcatcgc aggtcgagcc aactactgcc gggccgggtg
2200561 accgcagctc gtgctgaggc agcaccgagg ctggctgact caagcagtct cggcgtatgc
2200621 cagcctgatc gcgaacacgg gagtcaaccg gggcaaccgc cgtccgccgg acaacctcga
2200681 tccgatatca attaagcgat atcgtcatct ccgatggagc agatcgtgat ccgcaacctt
2200741 cccgagggga ccaaggcggc actacgggtc cgtgctgcac gtcatcacca ctccgtcgaa
2200801 gcggaagccc gcgcgatcct caccgcggga ttgttgggcg aagaagtccc catgccggta
2200861 ctgctggccg ccgacagtgg ccatgacatc gacttcgagc ccgaacgtct cggcctgatc
2200921 gcccgcaccc cgcaactgtg acctacgtcc tggacaccaa cgtggtgtcc gctttgcgcg
2200981 tgccgggacg ccaccccgcc gtggcggcgt gggcggactc ggtgcaagtc gccgaacagt
2201041 tcgttgtggc gataacgctg gccgagattg agcgaggcgt gatcgccaag gaacgcaccg
2201101 acccgaccca gagtgagcac ctacggcgct ggttcgacga caaggtgctg cgcatattcg
2201161 tgttcgcccg ccggggcaca aacctcatca tgcagcccct agctgggcat ataggttaca
2201221 gcctatattc tggtataagc tggttttaga cgaaaaggac cccacctcgg ggtctgatgg
2201281 ccaggggcag ggtcgtgtgc attggggatg caggttgcga ctgtacaccc ggcgtgttcc
2201341 gcgcgacagc gggtgggatg ccggtgctgg tggtcatcga gtctgggaca ggaggtgatc
2201401 agatggctcg taaagctacg tccccgggta agccggctcc gacgtcggga cagtatcgcc
2201461 cggttggcgg tggcaacgag gtgaccgttc cgaagggaca ccgtctgcct ccctcgccca
2201521 agcccggtca gaagtgggtg aacgtcgatc cgacgaagaa caagagcggc cgcggctgag
2201581 cttgtgccgt cgggatgggt gtcgcaccgt ctcggcgggt cgcccaagtg cataagtgct
2201641 ttgtcgctgc cctccggtac cgtcggagcc ccgtccaagc cggacaacga cgccactcga
2201701 ggcaggacaa gaccaactgt gccgccccct gatccagccg ccatgggtac ctggaagttc
2201761 ttccgggcat ctgtggatgg ccggccggta ttcaagaagg agttcgacaa gcttcctgat
2201821 caggcccggg ccgcgctgat cgtgctaatg cagcggtatc tcgtcggcga cctcgccgca
2201881 gggagcatca aaccgattcg tggcgacatt ctggagttgc gatggcatga ggcgaacaac
2201941 cacttccggg tactgttctt ccgctggggc cagcatcccg tagcgctgac agcgttctac
2202001 aagaaccagc agaagactcc caagacgaag atcgagacgg ccctggaccg gcagaaaatc
2202061 tggaaaagag ccttcggcga caccccaccg atctgaacaa cgcccaacca ctgttacgag
2202121 gctaggagag cacaaccatg agcattgact tccctttggg tgacgacctc gccggctata
2202181 ttgccgaggc gattgcggct gatcccagct tcaaaggcac tctcgaagac gccgaggagg
2202241 cacgcaggct ggtcgatgcg ctgattgcgc tgcgcaagca ctgccagctg agccaggttg
2202301 aggttgctaa gcgtatgggg gtgcgccagc ccaccgtgag cggtttcgag aaggaaccca
2202361 gcgaccccaa actgtctacg ctgcaacgtt atgcccgtgc attggacgcc cggctgcggc
2202421 tggtgctcga agttcccacg cttcgcgaag tgcctacgtg gcatcggctc tcctcttatc
2202481 ggggctccgc acgggaccac caggtccggg tgggtgcaga caaggaaatc ctgatgcaga
2202541 cgaactgggc ccgccacatt tcggttcggc aggttgaggt ggcatgactg accgaaccga
2202601 cgccgacgac cttgacctgc aacgcgttgg cgcgcggctg gcagcccgcg cacagatccg
2202661 cgatatccgg ctgctgcgca ctcaggccgc tgtccatcgt gcgcccaagc ctgcgcaggg
2202721 cctgacctac gacctcgagt tcgaacccgc tgtggatgcc gatccggcca ctatctcagc
2202781 atttgtggtg cggatttctt gccacctgcg cattcaaaac caggcggcag acgacgacgt
2202841 caaggaaggc gataccaaag acgagacaca ggacgtagcc accgctgatt tcgagttcgc
2202901 ggcactgttc gactaccact tgcaagaagg tgaagacgac cccaccgaag aagaacttac
2202961 ggcatacgcc gccacgaccg ggcggttcgc gctttatccg tacatccgcg aatacgtcta
2203021 cgacctcacc ggccgtctcg cactgccacc gttgaccctt gagatattgt ctcggccgat
2203081 gccggtttct cccggcgccc aatggccggc aacgagagga acgccctgac caaacgaggg
2203141 tgaatcaagc tgcccgacga ccatggtttc cacacctacc gccagatgca gcgctggact
2203201 gtcagcccag cggcacgggt cgagatcctg ggccgctact ggtggagaat ccgccgccgt
2203261 gccaccgaag gggcgaaggc gaaatccaaa ggcaaggccc gccgcggctc tcagttcaag
2203321 gttctcgaac acgggtgatg cggttcgagc ccgggaaggt ggagcgttag ccgcagggga
2203381 gggaatcttg gcgggtcggc cgacaagagg ttgaacttga ctgcgggaca gcagtttacg
2203441 gctcttgtcg ccacgcctac agcggattcg cataccgccg gggttcattg acaaccggcg
2203501 ggggttcgtt ccgccgtgtt tccgaggtag gtatcggcgg gggtgtatgt cggtaggcct
2203561 cgggaatgtc cgacaggcgc gatgggagat cttcgcgttg atcaccgcgc caatggatgg
2203621 tgtcgggatc atcccccggc tgacgggaaa tgcggccggc cattcttcct caagatcgag
2203681 tcagaggttc cggtcgacgt ccatccgttg gtgcaggact cgcacgacgt cgatggtgcc
2203741 ttcgccagtc acccgataga acaacgtgtg tgacccggcc gagagcttgc gatagccggg
2203801 gcgaatctcg tcgcacgctc gtccgatccg cgggtttgcc gcagcacggt cgatagcgtg
2203861 ttgaagttcg cgcaggtact gctcggcctg atcgacaccc caacggtcat aggtgcagtc
2203921 ccagatctct tccagatgtg cctgcgcggc aggcgagaga aggtatcggc tactcaccgg
2203981 ccacgcgagg cgtcagcccg cttacgaccg aggaatccgt cgaagtcgaa cggtgtcgag
2204041 ctgccgctgc gttcgccggc ctcgagagcc tcacgaagcg cgcgcagctg ggtttcacgg
2204101 tcctcgagca gtcgcaacgc ggagcggatg acttcactgg ccgaccggta gcggcccgcg
2204161 gcgatctcgc cgtcgatgaa ggcgctgtag tgctcgtcga ggacgaagga cgtgttctta
2204221 cccacgaacg cacaatacca attgttggta gtaggtgtta gcccctggga caccccaagc
2204281 cccagcggca gaatctcctg gggatcggca tggccgcacc aggcgcggcg cgcccagaca
2204341 tgtcagaggg tgaggcgaca ctggatgatc gacaccaccg aagcggcata tcggctgacg
2204401 tatcagccgg acggcacgtc gatcaccgtc cgggagaacc tggtcgacat cctggcgcgt
2204461 gagctgctcg gcccgatccg cggcccgcag gaggtgttgc cgttcagccc gcgctcgcaa
2204521 tacctggtcg ggcacctcgc cccggtaaag ctgaccggcg ccgcgctcat cgacgacaac
2204581 gcggtccagg cccgtgccaa cgccgaggcg ctcgccgagg gcggtggcgt gccggcctac
2204641 gcggccgacg aaacgacgcc gacaccgacg acgacgccca agaccgcgca cccaagcagg
2204701 gcctgatgat cccggcatca atgggtttac ggtttcaggt gccacccgat ctggtgtcgt
2204761 tcaccatcac cgcgtcatgg ataacctacg agaccgtcga gagcgggagg tgaccaaggc
2204821 cggccgtacg atagccagcg cgatagcagt gatctcgtcc cggcttcatc gcgcttgtcc
2204881 gggtgcgacg accgccaacg acagggcctc ggcggcttcc ttaaggcggt tgtcgtaggt
2204941 aaccagcgcg gtcaatggtg caacggatcc ggcggtttga gcagtggcta ggtgtatcgc
2205001 gtcgagcgag cgcagtgctg ggttggggta ggccgccgcg gtggagcgta tgaccgcgtc
2205061 gatttcgaaa cggtccagcc tggctagcac ggagggcacc gccggtagcc cttctgggga
2205121 gactgcgcgg atggctctgg atagctcaac ttcggtcaaa gccgatgtga tccaccgtag
2205181 ttcggtgcgg tcatcgagcc aatcagctaa agcgtcagat tcgacctcga tccgaattag
2205241 cttgaccagc gccgaggttt ccaggtagat cacgcgctag taccgctcct cggcgcgcat
2205301 gcgctccaac agcgttcccg agtcgagacc gccgcgcatc ggaattgtgg gccgaggcgc
2205361 cgggccatgc actctcgccg gttgcacact gccggtgctg atcagtgagt cgagagggcc
2205421 ggcagaagcc gggattattc gggcgataac cttgccgcgc tcagtcaggt tgatctcttc
2205481 accgcgcttg acgcgggcca ggaccttgga cgtctcctgg ttgagcgttc gtatggacac
2205541 ctcattcaca ccgataatgt actacctatt tgttctacat gctatgcgcg caagaggtta
2205601 cctgccccgc tggtcaggat cgccagcgcc aggccactga tctcgtcggc gactccggcg
2205661 tagcgcgtga gatgccaggt gcgagcgacg tcttcgatga agctaatcgc cgccgcgacc
2205721 agcagtcgcc cctgggcgac actggtcgcg ggtaccagct tgccgatgag gtcgatccac
2205781 acggcctcgc ggtcgccctg atttcgcagg tagccgtcgc gtacttcgac agaggcgtgc
2205841 gacagttcgg tgaccgacac tgccaccaga tccggagcgt ccaagctgat ccgaacgtgc
2205901 ccttggacaa ggccgcgcaa ccgttgtgcc gcttgctgat tcgctcgtag cgctcggatg
2205961 cactccaggc agcgccactc gtcgaggcgg cggatgagcg cgtccaggat ggcctgtttg
2206021 gaagaaaacg aacggtacag ccccgggccc gcgatgccgg ctcccttgcc gatttcgctg
2206081 gtgttgacgg ccggatagcc ctgcgcacgg aacagccgcg cgcccgcggc cagcagggtc
2206141 tcgtagcggg agaacagcac gtcggcctcg tcgcgtgcgg catcaccggc cggcagtggc
2206201 ggcaattcgc agacgggagg cgtccttgcc gcggccatac acgcctggta gagaagcttt
2206261 ttcagttcct cgcccggcag gcttaggctg tgccggccca ggctggtcaa agtgctggac
2206321 accgcccacg cccgcaactc cgaatgctgt ggactcagat cgggcacctc cagcagcacg
2206381 ctgtcacgca tgccggcgac gatcgcgttg atgcggcgcc ggaccgccgt gcggtcgtcc
2206441 tcgttgaggt agcgggcctc gcgctgccac agcaccgtca acgcccgaga ggcgaccgcc
2206501 gcggcgatca ggtcttccag atcggcgttc aacggccgcg gcgtcggctc cgtctcgccc
2206561 tcggtgagac gacgcgcgct ctggtactga tcctggccgg ttcggatcgc ttcggcgagc
2206621 aacgcctgct tgttgtcgta gtggcgatac aacgcgcgcg cggtcacccc ggccgcctcg
2206681 gcaatgtcct ccaatttgac cgaatggaag ccacgttcga tgaacagtcc aacggcctga
2206741 tccaaaatct gcttcttccg gtcctttggg cggcgcctaa cgggttgggc gacggatgcc
2206801 atcggctcga acccccttct tgcgcaccgg aatcacaaat cctgctagca gcatcgcctc
2206861 agcttcaccc cgctcattct tcacctcgaa tgcgccggtc accgggtgcg acacttaccg
2206921 gccgtcgttc atggtgacgt ttcgaggctg tgctgctgcc aagaccccag gaagtctcgg
2206981 acgagagact cgctagcctc cgtggtatcg ggcatcccta tcacccctgc tcgatcctca
2207041 atatcggact aacaaaatac atcatcgcgc ctgtatacgc gattacattg caatttatcc
2207101 ttatcaccct tcttagagtg catatcagta atagacatat cgcgctcctc gcgccccagg
2207161 aggcggtcga cgaattcgcc gtgcgcaacg acatgagccg tcgctgagcc tgaaaacctg
2207221 cagacaaagc gcgagtgggg gctggcaaaa ctacaggctc gttagcagca agttgcttcg
2207281 acgaccatgg tggcaacctc gccggtcgcg aaggctctgg tcggcgggcc cgaatcgagg
2207341 cggtcaggat gcggcatccg atcaccgccc gtcgggcgcg ctgttgatgc ctgatcgtgg
2207401 tgcctcgcca gcgtgactcg agccaacggc ttgaccggtg atgcgcctgt cggccgccaa
2207461 ggcagcagag cacatcgccc cgcgctatag gatactagca agatacatca tagccaatat
2207521 atgccagttt gcattgctat ttaccgatca gttgtccaag caatcgcgta ttggctatgg
2207581 acatcagcgg ttctgccgcg tacgctcacc aatgtcaccg atcgtcgacc tgtccggggg
2207641 gccagcgtgc gccacctcac ccaacggccc agcatcgaat ccagctggtg cgccgcgcca
2207701 tggtaatcgt ggccgacaag gcggccggtc gggtcgctga tccggtcttg cggccggtgg
2207761 gcgcgctggg cgatttcttc gcgatgacgc tcgacacgtc cgtgtgcatg ttcaagccgc
2207821 ctttcgcgtg gcgtgaatac ctacttcagt gctggttcgt ggcgcgggtg tcgacgctgc
2207881 ctggggtgtt gatgacgatc ccatgggcgg tgatctcggg gtttctcttc aacgtcttgc
2207941 tgaccgacat cggtgccgcg gacttttccg gcaccggctg tgcgatcttc accgtgaacc
2208001 aaagcgcccc gatcgtcacg gtcttggtgg tcgcgggcgc gggcgccacc gccatgtgcg
2208061 ccgatctggg tgcgcgcacc atccgtgagg aactcgacgc actgcgggtg atgggcatca
2208121 acccgatcca agcgctagcg gctccgcgcg tgctggcggc caccacggtg tcgttggcgc
2208181 tgaattcggt ggtgaccgcg acggggctga tcggcgcgtt cttttgctcg gtgtttctca
2208241 tgcacgtctc ggcgggggca tgggtgaccg ggcttaccac gctgacccac accgtggacg
2208301 tcgtcatttc gatgatcaag gcgacgttgt tcgggctgat ggccggactg atcgcctgct
2208361 ataagggcat gtcggtcggt ggcggcccgg ccggagtcgg ccgggcggtg aacgaaaccg
2208421 tggtgtttgc cttcatcgtc ttgttcgtga tcaacatcgt cgtcaccgcg gtcggcatcc
2208481 cattcatggt gtcctgaggt gaacccatga cggcagcgaa agcccttgta agcgaatgga
2208541 atcggatggg atcgcagatg cggttcttcg tcggcacgct ggccgggatt cccgacgccc
2208601 tcatgcacta ccgcggcgag ctgctgcggg tgatcgcgca aatggggttg gggaccgggg
2208661 ttcttgcggt gatcggtgga acggtcgcga tcgtcgggtt cttggcgatg accaccggcg
2208721 cgatcgtggc cgtgcagggc tacaaccagt tcgcttcggt gggtgtggag gcgctgaccg
2208781 gcttcgcgtc ggccttcttc aacacccgcg agattcagcc cggaaccgtg atggtcgcgc
2208841 tagcggccac cgtcggtgcc ggtaccaccg ctgcgctggg ggcgatgcgg ataaacgagg
2208901 agatcgacgc gctcgaggtg atcggcatcc gcagcatcag ctacctggcg agcacccggg
2208961 tgctggccgg agtggtcgtg gccgtccctc tgttctgtgt gggactgatg acggcctacc
2209021 tggccgcgcg cgtcggcacc accgccatct atggccaggg gtcgggcgtg tacgaccact
2209081 acttcaacac gttcctgcgc ccgaccgacg tgctctggtc gtcggttgaa gtcgtcgtgg
2209141 tcgctctgat gatcatgctg gtgtgcacct attacggcta cgccgcacat ggcgggccgg
2209201 ccggggttgg cgaggcggtc ggccgggccg tgcgtgcctc gatggtcgtc gcgtcgatcg
2209261 caatccttgt catgacgctg gccatctacg gccagtcgcc caactttcac ctggcgacct
2209321 agtgacatga gacgcgggcc gggtcgacac cgtttgcacg acgcgtggtg gacgctgatc
2209381 ctgttcgcgg tgatcggggt ggctgtcctg gtgacggcgg tgtccttcac gggcagcttg
2209441 cggtcgactg tgccggtgac gctggcggcc gaccgctccg ggctggtgat ggactccggc
2209501 gccaaggtca tgatgcgcgg tgtgcaggtc ggccgggtcg cccagatcgg tcggatcgag
2209561 tgggcccaga acggggcgag cctcagactg gagatcgacc ccgaccagat ccggtacatc
2209621 ccggccaatg tcgaggcaca gatcagcgcc accaccgcat tcggtgccaa gttcgtcgac
2209681 ctggtgatgc cgcaaaaccc aagtcgtgca cggctgtccg ctggggcggt actgcattcg
2209741 aagaacgtca gcacggaaat caacaccgtc ttcgaaaacg tcgtcgacct gctcaacatg
2209801 atcgacccgc tgaaactgaa cgccgtgctg accgcggtcg ccgacgccgt tcgcgggcaa
2209861 ggtgaacgga taggccaggc caccaccgac ctcaacgagg tgctggaggc actcaacgca
2209921 cgcggcgaca ccatcggcgg caactggcga tcgctcaaga acttcaccga cacctatgac
2209981 gcggccgccc aagacatcct gacgatcctg aacgccgcca gcaccaccag tgcgaccgtc
2210041 gtgaatcatt cgacgcagct ggatgccttg ctactcaacg ccatcggact atccaacgct
2210101 ggcaccaacc tgcttggcag cagccgagac aatctcgtcg gcgcggccga catcctggcg
2210161 ccgaccacga gcctgctgtt caagtacaac cccgaataca cctgcttcct gcagggcgcc
2210221 aagtggtatc tcgacaacgg cggctatgcg gcctggggcg gggccgacgg gcgcacgcta
2210281 caactcgatg tggcgctact gttcggcaac gacccctatg tctatccgga caacctgccg
2210341 gttgtcgcgg ccaagggggg tcccggcgga aggccgggat gcgggccatt gccggatgcc
2210401 acccacaact tcccggtgcg ccagctggtc accaacaccg gatggggaac cgggctggac
2210461 atccggccca accccggcat cgggcatccc tgctgggcca actacttccc ggtgacccgc
2210521 gcggtgcccg agccgccgtc gatccgtcag tgcatccccg ggccggcgat cgggcccaac
2210581 cccgcggcgg gggagcagcc atgagggaga acctgggggg cgtcgtggtg cgcctcggcg
2210641 tcttcctggc ggtatgcctg ctgacggcgt tcctgctgat tgccgtcttc ggggaggtgc
2210701 gcttcggcga cggcaagacc tactacgccg agttcgccaa cgtgtccaat ctgcgaacgg
2210761 gcaagctggt gcgcatcgcc ggcgtcgagg tcggcaaggt caccaggatc tccatcaacc
2210821 ccgacgcgac ggtgcgggtg cagttcaccg ccgacaactc ggtcaccctc acgcggggca
2210881 cccgggcggt gatccgctac gacaacctgt tcggtgaccg ctatttggcg ctggaggaag
2210941 gggccggcgg actcgccgtt cttcgtcccg gtcacacgat tccgttggcg cgcacccaac
2211001 cggcgttgga tctggatgcc ctgatcggtg gattcaagcc gctgtttcgt gcgctgaacc
2211061 ccgagcaggt caacgcgctg agcgaacagt tgctgcacgc gtttgccgga caggggccca
2211121 cgatcgggtc attgctggcc cagtccgcgg ccgtgaccaa caccctggcc gaccgtgatc
2211181 ggctgatcgg gcaggtgatc accaacctca acgtggtgct gggctcgctg ggcgctcaca
2211241 ccgatcggtt ggaccaggcg gtgacgtcgc tatcagcgtt gattcaccgg ctcgcgcaac
2211301 gcaagaccga catctccaac gccgtggcct acaccaacgc cgccgccggc tcggtcgccg
2211361 atctgctgtc gcaggctcgc gcgccgttgg cgaaggtggt tcgcgagacc gatcgggtgg
2211421 ccggcatcgc ggccgccgac cacgactacc tcgacaatct gctcaacacg ctgccggaca
2211481 aataccaggc gctggtccgc cagggtatgt acggcgactt cttcgccttc tacctgtgcg
2211541 acgtcgtgct caaggtcaac ggcaagggcg gccagccggt gtacatcaag ctggccggtc
2211601 aggacagcgg gcggtgcgcg ccgaaatgaa atccttcgcc gaacgcaacc gtctggccat
2211661 cggcacagtc ggcatcgtcg tcgtcgccgc cgttgcgctg gccgcgctgc aataccagcg
2211721 gctgccgttt ttcaaccagg gcaccagggt ctccgcctat ttcgccgacg ccggcgggct
2211781 gcgcaccggc aacaccgtcg aggtctccgg ctatccggtg ggaaaagtgt ccagcatctc
2211841 gctcgacgga ccgggcgtgc tggtggagtt caaggtcgac accgacgtcc gactcggaaa
2211901 ccgcaccgaa gtggcaatca aaaccaaggg cttgttgggc agcaagttcc tcgacgtcac
2211961 cccccgcggg gacggccgac tcgattctcc gatcccgatc gagcggacca cgtcgcccta
2212021 ccaactgccc gacgcccttg gcgatttggc cgccacgatc agcgggttgc acaccgagcg
2212081 gctgtccgaa tcgctggcca ccctggcgca gacctttgcc gatacgccgg cgcacttccg
2212141 caacgccata cacggggtgg cccggctcgc ccaaaccctc gatgagcgcg acaaccaact
2212201 gcgcagcctg ctggccaacg cggccaaagc caccggggtg ctggccaacc gcaccgacca
2212261 gatcgtcggc ctggtgcgcg acacgaatgt ggtcttggcg cagctgcgca cccaaagcgc
2212321 cgccctggac cggatctggg cgaacatctc ggcggtggcc gaacaactgc ggggcttcat
2212381 cgctgagaac cgccagcagc tgcgcccggc gctggacaag ctcaacgggg tgctggctat
2212441 cgtcgaaaac cgcaaagagc gtgtgcggca ggccatcccg ctgatcaaca cctatgtcat
2212501 gtcgctgggt gagtcgctgt cgtcgggccc gttcttcaag gcatacgtgg tgaacctgct
2212561 gccgggtcag ttcgtgcaac cgttcatcag cgccgcgttc tccgacctgg ggctcgaccc
2212621 ggccacgttg ctgccgtcgc agctgaccga cccaccgacc ggtcaacccg gaaccccgcc
2212681 gttgccgatg ccctacccgc gcacgggcca gggcggtgag ccgcggctga cgctgcccga
2212741 cgcgatcacc ggcaatcccg gcgatccgcg ctatccgtac cggccggagc cgcccgcgcc
2212801 gccgcccggc gggccgccgc ccggcccgcc cgcgcagcag ccgggagacc aaccgtgaca
2212861 acgaaactca gacgtgcccg ctcggtgttg gcgaccgccc tggtgctggt cgcgggcgtg
2212921 atcctggcca tgcgcaccgc cgacgccgcc gcccgcacga ccgtggtcgc ctacttcgac
2212981 aacagcaacg gtgtgttcgc cggtgacgac gtgctcattc ggggcgtgcc ggtgggcaag
2213041 atcgtcaaga tcgaaccgca accgctgcgc gccaagattt cgttctggtt cgaccgcaaa
2213101 taccgagtcc ccgccgatgc cgccgcggcg atcctgtcgc cgcaactggt gaccggccgg
2213161 gccatccagc tgacaccgcc gtatgccggc gggccgacca tggccgacgg cacagtaatc
2213221 ccgcaagagc gcaccgtggt gccggtggag tgggacgact tgcgggcgca acttcagcgg
2213281 ctgaccgcat tgctgcagcc cacccggccg ggcggcgtca gcacgctggg tgcgctcatc
2213341 aatactgccg ccgacaacct gcgcgggcaa ggcgccacca tccgcgacac catcatcaaa
2213401 ctgtcacaag cgatttcggc tctcggtgac cacagcaaag acatcttctc caccgtgacg
2213461 aacctgtcga cgctggtcac ggcgctgcat gacagcgctg acctgctcga acggctcaac
2213521 cacaacctgg ccgcggtgac ctcgctgctg gccgatggcc cggacaagat cggtcaggca
2213581 gccgaggacc tcaacgcggt cgtagccgac gtcggcagct tcgccgccga gcaccgcgag
2213641 gcgatcggca ccgcatcaga caagctcgcg tcaatcacca ccgcgctggt cgacagcctc
2213701 gacgacatca agcagacgct gcatatcagc ccgacggtgt tgcagaactt caacaacatc
2213761 ttcgaaccgg ccaacggcgc gctgaccggc gcgctggcgg gcaacaacat ggccaaccca
2213821 atcgccttcc tgtgcggcgc gatccaggct gcctcccggc tgggcggcga gcaagcggcc
2213881 aaattgtgcg tgcaatacct ggcgccgatc gtgaagaacc gccagtacaa ctacccgccg
2213941 ctgggggcga acctgttcgt cggggcgcag gccaggccta acgaggtcac ctacagcgag
2214001 gactggctgc ggcccgatta cgttgcacca gttgcggaca cgccgccaga tccggccgcg
2214061 gccgtgaccg tcgatcccgc gaccggcctg cgcggcatga tgatgccgcc ggggggtggc
2214121 tcgtgaggat cggcctgacc ctggtgatga tcgcggccgt ggtagcgagc tgcggctggc
2214181 gcgggctgaa ttcgctgccg ctgcccggca cgcagggcaa cggcccgggg tccttcgcgg
2214241 tccaggcgca gctgccggat gtcaacaaca tccagccgaa ctcgcgggtg cgggttgccg
2214301 acgtgacggt cggccacgtc acgaaaatcg agcgccaagg ctggcacgcg ttggtgacca
2214361 tgcggctgga tggcgacgtc gatttgcccg ccaacgcaac ggccaagatc ggcaccacca
2214421 gcctgctggg ttcctaccac atcgagctgg cgccaccgaa aggcgaagcg cggcaaggca
2214481 agctgcgcga cggttcactc attgcgctgt cacacggtag cgcctaccca agcaccgagc
2214541 agacgctggc agcgctgtcg ctggtgctca acggcggcgg actgggccag gttcaagaca
2214601 tcaccgaggc gttgagcacc gcgtttgccg gccgtgagca cgatctgcgc gggctgattg
2214661 ggcagctgga caccttcacc gcatacctca acaaccagtc cggtgacatc atcgcggcca
2214721 ccgacagcct caaccgcctc gtcggcaagt tcgccgacca gcaacccgtc ttcgatcggg
2214781 ccctggccac catccccgac gcgctcgcgg tgctggccga tgagcgggac acgctcgtcg
2214841 aggctgccga gcagctgagc aagttcagcg ccctgaccgt cgactcggtc aacaagacca
2214901 ccgcgaacct ggtcaccgaa ctgcggcaac tcggaccggt gttggagtcg ctggccaatt
2214961 ccggtccggc gctgacccga tcgctgtccc tgctggccac gttcccgttc ccgaacgaga
2215021 cgttccaaaa tttccagcgc ggcgaatacg ccaacctgac cgcgatcgtc gacctcacgc
2215081 tcagccgcat cgaccagggc ctgttgaccg gcacccgctg ggagtgtcat ctgacccagc
2215141 tcgagctgca gtggggtcgc accattgggc agttccccag cccgtgtacc gcgggctatc
2215201 ggggtacccc gggcaatccg ctgacgatcg cctaccgctg ggatcagggg ccctagatgc
2215261 tgcatctacc gcgccgagtg atcgttcagc tggccgtctt taccgtgatc gcggtgggcg
2215321 tgctggccat cacgttcctg catttcgtga ggctgccggc gatgcttttc ggcgtcggcc
2215381 gctacacggt gacgatggag ctggtcgaag ccggtgggct gtatcgcacc ggcaatgtca
2215441 cctaccgcgg ctttgaggtg ggccgggtgg cagcggtgcg gctcaccgac accggggtgc
2215501 aagcggtgct ggccctgaaa tcgggcatcg atatcccgtc ggacctcaag gccgaggtgc
2215561 acagccacac cgcgatcggc gaaacctacg tcgagttgtt gccgcgcaac gccgcctcgc
2215621 cgccactgaa gaacggcgat gtcattgcgc tggccgacac ctcggtgccg cccgacatca
2215681 acgacctgct cagcgcggcc aacaccgcat tggaggcaat acctcacgag aacctgcaga
2215741 ccgtcatcga cgagtcgtac accgcggtgg ccgggttagg gctcgaactt tcccggctga
2215801 tcaagggctc ggcggaactg gcgatcgatg ctcgcgcgaa tctcgatccg ctggtggcgc
2215861 tgatcgaccg ggcaggaccg gtgctggatt cgcagaccca cacctcggat gcgatcgcgg
2215921 cctgggcggc acagctggcc gcagtcaccg gccaattgca gacacacgac tcggcggtcg
2215981 gcgatctcat cgaccggggc ggtccggcgt tgggggagac gcgccaactg ctcgagcggc
2216041 tacaacccac cgtgcccatc ctgctggcca acctggtcag cgtcggccag gtcgcactca
2216101 cctatcacaa cgacatcgaa cagctgctgg tggtgttccc catggccatc gccgccgaac
2216161 aggccggcat cctggccaac ctcaacacca agcaggccta ccggggccag tatctgagct
2216221 tcaacctcaa cctgaacctg ccgccgccgt gcaccaccgg ctttctgccg gcccagcagc
2216281 ggcgcattcc cacgttcgag gactacccgg atcgcccggc cggtgatctg tactgccggg
2216341 tgccccagga ttcgccgttt aacgtgcgcg gcgcccgcaa catcccctgt gaaaccgtgc
2216401 cgggcaagcg cgcacccacc gtgaagttat gcgagagcga cgcgccatac ctgccgctga
2216461 acgacggcta caactggaag ggcgacccca acgccacggt gccgggtttg gggtccggcc
2216521 aggacatccc gcagacatgg caaacgatgc tgctgccgcc gggcagctga cggtgatgga
2216581 gggaggacac gatgtcggta gcagtggatt ccgacgccga ggatgacgcc gtatcggaga
2216641 tcgctgaggc agccggcgtg tcgccggccc cagccaaacc atccatgtcg gcgccgcggc
2216701 gcatgctgct gttcggcctg gtcgtcgtcg tcgctttggc ggtgctgttg tgttgctggg
2216761 gatttcgcgt ccagcgggca cgccatgcgc aggaccagcg tggtcacttc ctgcaagcgg
2216821 cccggcagtg cgcgctgaac ctaacgacca tcgactggcg caacgccgag gcggatgtgc
2216881 gccgcattct ggacggcgcc acaggcgagt tttacaacga cttcgcccag cggtcccagc
2216941 ccttcgtcga agtactgagg cacgcaaagg ccagcacggt cggcacgatc accgaggccg
2217001 ggctgcagac gcagaccgcc gacacggccc aggcgctggt ggcggtgtcc gtgcaaacgt
2217061 cgaatgccgg cgaagccgac ccggttccac gagcgtggcg aatgcgcatc accgtgcagc
2217121 gggtcggcga ccgggtcaag gtgtccgacg tcgggttcgt gccgtgagct ggtcgcgggt
2217181 gatcgcctac gggctgctgc ccgggctggc gttggcgctg acgtgtggcg cgggcttgct
2217241 gaaatggcag gacggcgccg tccgcgacgc cgcggttgcc cgtgcggaat ccgtgcgggc
2217301 cgcgaccgac ggcaccaccg cgctgctgtc ttaccggccc gacaccgtgc agcatgacct
2217361 cgagagcgcg cgaagcaggc tcacgggcac gttcctcgac gcctacacac agctgaccca
2217421 cgacgtggtg atccccggcg cacagcagaa gcagatctcg gccgtggcca ccgtcgcggc
2217481 cgcggcgtcg gtgtcgactt ccgccgaccg cgccgtcgtc ctgctgttcg taaaccagac
2217541 catcaccgtc ggcaaggacg cgccgaccac cgccgcttcc agcgttcggg tgaccctcga
2217601 caacatcaac gggcgttggc tgatctcgca attcgaaccg atctgacggg gggcaccagt
2217661 gcagcgccaa tcattgatgc cccagcagac ccttgccgcc ggcgttttcg tgggtgcgct
2217721 gctatgcggt gtcgtgacgg cggcggtgcc accacacgca cgcgccgacg tggtcgccta
2217781 tctggtcaac gtgacggtac gcccgggcta caacttcgcc aacgccgacg ccgcgttgag
2217841 ttacggacat ggcctctgcg agaaggtgtc tcggggccgc ccttacgcac agatcatcgc
2217901 cgacgtcaag gctgatttcg acacccgcga ccaataccag gcctcgtatc tgctcagcca
2217961 ggctgtcaac gaactctgcc ccgcgctgat ctggcagttg cgaaactccg cagtcgacaa
2218021 tcggcgctcg ggctgaggta aggggactga catgtcgcgt cgagcatcgg ccacgtgtgc
2218081 cttgtccgcg accaccgccg tcgccataat ggctgctccc gccgcacggg ccgacgacaa
2218141 gcggctcaac gacggcgtgg tcgccaacgt ctacaccgtt caacgtcagg ccggctgcac
2218201 caacgacgtc acgatcaacc cgcaactaca attggccgcc caatggcaca ccctcgatct
2218261 gctgaacaac cggcacctca acgacgacac cggttctgac ggatccacac cgcaagaccg
2218321 cgcgcatgcc gccggcttcc gcgggaaagt cgctgaaacc gtggcgatca atcccgccgt
2218381 agcgatcagc ggcatcgagt tgataaacca gtggtactac aaccccgcgt ttttcgcgat
2218441 catgtccgac tgcgccaaca cccagatcgg ggtgtggtca gaaaacagcc cggatcgcac
2218501 cgtcgtggtg gccgtttacg gacagcccga tcgaccttcc gcgatgccgc ccaggggagc
2218561 ggtaaccgga ccgccgtccc cggtggccgc gcaagagaac gttcctatcg accccagccc
2218621 cgactacgac gccagcgacg agatcgaata cggcatcaac tggctgccat ggatcctgcg
2218681 cggcgtgtac ccgccgcccg caatgccgcc gcagtaggcg gtcgctagcg caccgctgag
2218741 ttccgcggct gccagatctg ggccgggcac cggagattaa ccgcgtggga gaccggcagt
2218801 tccagcagcg catctgaggc gtcttcgatc gccggagccc taatcactgc gtgcggcggg
2218861 ccgcgttcga cccgcgcggg tcgataaggt cacggaaccg ttctgccggg tagactgccg
2218921 cacccaagtc tcggacccgg tcggtcaacg ctttgtccga tgtcaccaca cgaatctctt
2218981 gtggctgggc gccggatcgg accagccgga cgatctcgtc gtcggccgag ttggcggccg
2219041 ccttgggcgc atgcgccact tcgaccaccg atgacgggat ggcggtcgac ggcggccgct
2219101 cgaacaccac cgtcacgtcg tcgccccgag ccttggtgat ggcccacccc tcgagccttt
2219161 ccaccagcat caccatcgcg cgatggcggt cgcgccacca accatccgga cgacttccga
2219221 tcacgttcat accgtcgaca atccaccgca cacctcacgg tacgacggcg ccacctcacc
2219281 gcgtgtgtcg acgccggcta tgcgtttgcc gcactaccac catctgcgct ttcggtgctt
2219341 cttcagctct tgctggaact tctggtaatg ctccagcgcg aatcgctctt ccaaagcccc
2219401 aagggcgtta atgacctcgg gatctttgac cccaggggtc gatggccaat ctcaggttgg
2219461 taaatcgggt gctcagatcg gccctccgga ccaggttgtc gcctgggcag atgtgcgctc
2219521 gctaaccgcc aactcacttt caaactacgc tgcgagttgt gagcgtaatg tcagtgatct
2219581 gacggcaaag gtcacggatt tcgtcgagca gatggacggt atttcgcgaa aagcggttcg
2219641 acctactggc tcctggtgtg tggcctccca gggtgctggg ctgcggtttc gccaaccaac
2219701 ctgctggtcg gcgcgccgta ttctgaagac cggaccaacg aggggaccga gccatgtctc
2219761 agacacccgc tacaacccgc aaaacgtttc ccgagatcag ctcaagagcg tgggagcacc
2219821 ccgccgaccg gaccgccctt tccgcgctgc gccggctcaa aggcttcgac cagatcttga
2219881 agctgatgtc ggggatgttg cgggaacggc agcaccggct gctgtacctg gccagcgcgg
2219941 cacgggtcgg gccgcggcag ttcgccgacc tcgacgcgct gctggacgaa tgcgtggatg
2220001 tgctggacgc gtcggcgaaa cccgaactct acgtgatgca gtcaccaatc gcggatgcct
2220061 tcaccatcgg catgggcaag ccattcaccg tgatcacctc ggggctgtac gacctggtga
2220121 cacacgacga gatgcggttc gtgatgggcc acgagctcgg ccacgcactg tccggccacg
2220181 cggtgtaccg cacgatgatg atgcatctgc tgcggttggc ccggtcattc ggcgtcttgc
2220241 cggttggcgg ctgggcgctg cgcgcaatcg tggctgcgct gctggaatgg cagcgcaaat
2220301 cggagctgtc cggcgatcgc gctgggttgc tgtgcgcgca ggatttggac accgcgctca
2220361 gggtggagat gaagctcgct ggcggctgcc ggctggacaa gctggactcg gaggccttct
2220421 tggctcaggc ccgggaatac gagacatccg gcgatatgcg cgacggggtg ctcaagctgc
2220481 tcaacctgga gctgcagacc catccgttct ctgtgctgcg ggctgccgcc ttgactcact
2220541 gggtggacac cggcggctat gccaaggtga tagccggcga gtacccgcgt cgggccgacg
2220601 acggcaacgc caaatttgca gacgaccttg gcgcggccgc ccggtactac cgggacggct
2220661 tcgaccagtc caacgacccg ctgatcaaag gtatccgcga cggattcggt ggcatcgtcg
2220721 agggcgtggg acgggcagcc tcgaacgcgg ccgattcatt gggccgcaag atcaccgagt
2220781 ggcggcagcc ctcgaagtga cggcccctct gctacgtagc taagcacgcg cgaccggcgg
2220841 gctggggagc ccggtcagcg gtctcatagc attgcgaaca cgggacgtcg agaggggaag
2220901 agctgccatg ggtgaggcga acatccgcga gcaggcgatc gccacgatgc cacggggtgg
2220961 ccccgacgcg tcttggctgg atcgtcgatt ccagaccgac gcactggagt acctcgaccg
2221021 cgacgatgtg cccgatgagg tcaaacagaa gatcatcggg gtgctcgacc gggtgggcac
2221081 cctgaccaac ctgcacgaga agtacgcccg gatagccctg aaacttgttt ctgacattcc
2221141 caacccgcga atcctggaac ttggtgcggg ccatggcaag ctctcagcga aaatcctcga
2221201 gctacacccg acagcgacgg tgacgatcag cgatctagat cccacctcgg tggccaacat
2221261 cgccgcggga gagctgggaa cacatccgcg agcacgcacc caagtgatcg acgccaccgc
2221321 aatcgacggc cacgaccaca gctatgacct ggcggtcttc gcgctggcat ttcaccacct
2221381 gccgcctacg gtcgcctgca aagcgatcgc cgaggccacc cgggtgggga agcgctttct
2221441 gatcatcgac ctcaaacggc agaaaccgct gtcgttcacg ctctcttcgg tgctgctact
2221501 gccgctccac ctactgctgc tgccatggtc gtcgatgcgc tcgagcatgc acgacggctt
2221561 tatcagcgca ctacgtgcct acagtccctc ggcgttgcag acgcttgccc gcgccgccga
2221621 tccgggaatg caggttgaaa tcttgcccgc accgaccagg ctattcccgc catcgctcgc
2221681 cgttgtgttc tcccgttcga gctcagcgcc aacggaatct agcgagtgct cggccgatcg
2221741 ccaacccggc gaatgattcg gtagtagtgc agataagcca tcgccggtac cacgatgaac
2221801 gtgatcacga tcaaagcaat cgagaagtag ttcggaccac cccgcactag aaagatgcag
2221861 cggtagtcgt aggacactgc cagcccaacc gagaccacga tcgcaacaag cggtaacacc
2221921 ttgtcggtga acgcatttcg ccgcacagca gcatgttcta ctgcctgaga cctcgccaat
2221981 gcgatgagag cgatcggcac gatgatgaac tggacgaatc gggcgatcac cgccaggccg
2222041 gtcaggtgca ggttgtcgaa ccgcagcgcc aacgggaatg cgagcgccaa cgacgccgta
2222101 attgcgaagg agaccatcgg cacgtcgtat tggttcttgc gtgacaagcg tgtcggcaga
2222161 accccgctgt ccgctaacgc ggtccaaagc cgcggtgcac cgaacgaggc cgcgacattg
2222221 atgccgaaca tcgatatcag ggctccgacg acgatgatcg ttcggaaggt agcgtttccg
2222281 atggccgcgg ccagtttcac ggtgtcgtcc gacgcggcga tcttgttcga tccgagcagc
2222341 atcgctaccg ttagggtgag caagtagatc gcgccaaccg agaagatcgc gatcggtata
2222401 gctctcggca ggttccggtc cggcgcgtcc atttcttcgg cggcgttcgc gatcgattcg
2222461 aaaccggtga atgcgtacaa cgcgacaatc gtggccagcg ccatactcga gaacgtgccc
2222521 ttgccaattt cggcgacgcc aagcaacgag tacggggtcg cgctgtatgc cgaccacgcc
2222581 gttgcgtagt tgttcacgtg ctgggtggtg atgatccaca gcccgccgac aatgaatgcc
2222641 gagagcgcga atgccttgcc taccgttgac gttccgttgg cccacttgat cgcccggttg
2222701 ccgaagaggt tgatggccaa cagcacgccg ataaagccga gaaacgtcag cgtcttcaca
2222761 ctgaacagtt gctcggcgtc ggcccaggcc ttgtcgggga aggccactcg caacagcgtc
2222821 gagacgaaaa aagaagccaa caccccccaa gcgatggacg cggtaatggc gtgggtgaca
2222881 ccgacataga tgccgatccg gcgcccaaat gcggccgttg tgtaggcgta ggaggcaccg
2222941 tttgttctga cgtaccttgc cgccgtcgcg aagacgatcg ccacgacacc cgcgaaaatg
2223001 ccagctaaaa cataggccat cggcgcgaag ggtcctgcga gcccgatcac ctcacctgga
2223061 gttaggaaga taccggcgcc gattatcgag ttgatcccga gcatgacgac gctgcagaaa
2223121 cccagcttgt ggatcgcata tcctctcgtc cgcgggccga ccaccgcacc aaggctgtct
2223181 agcagggaat cctctaacgc accatagatt ctctagcgac gattcttgag ctcccggcct
2223241 gtcgatgccg gcgctgcagg tgagtcaccg cagtgggcgc accgaacact catttccgcc
2223301 gccccaaatc cgcgcagtga ccaccgcgcg gtcctcgcga gtctaggcca gcatcgagtc
2223361 gatcgcggaa cgtgggacca atacctgggt tgggccggct gcttcgggca gcaactcccc
2223421 cgggttgaag aagaaaatca ccccgtcgtt cgtgactgcg aagttctgat aattcaccgg
2223481 gtccaagccg gcattcggcg ctatcgatac ctgttgtccg gtctgcttgc tcagttcacc
2223541 ttgcacaatg gggaagacga ctggcagcgg atcggtgtca gcctgccaca gcgtgtcata
2223601 ggtgattggc ttgcgatagg cctggtccca atcgaaggcc ttgtacgtgg tcgttgggtg
2223661 cgtgccgccg gcgttctggt agaccttgag caccacggcc tgcgtaccac gcggcggtat
2223721 cgcggactgg tatgtggccg aggtgatatt caattcgtag ggggcttcgc gtggagtgga
2223781 cgatgtggcc gcgctgagga acttgtcgcg cgtctgggcg atgtaatttt ccagcgactt
2223841 ctggtcgggg tagtaactgg gcaggctgat gttgatgttg taggccgggt cggacatttg
2223901 aatctggcac gcctggccgg tatcggtgcc tttcaactcc tcgcagtagg tcttgggcgc
2223961 ggccgtggcc acacccgaac aacagagcaa aacgacagcc gtgaccagca tgaagatctt
2224021 gatgcgcacg tcgaaattcc tccgggagta gtttgcagca ccgccggccg caggcgggag
2224081 attggattgc cgcgatatct gagtcgacga caaacatagg gcatcgcgct gctgacgacg
2224141 atgcctgacc agactcaagc tagcagatcg atcgggcccg gtgtcgcgtg gtgctcgacg
2224201 cccccgacgc gctgggcggt tagaagtccc agtcggtgtc ggtggtgggt tggtgggtgc
2224261 ccattacgta tgagcttccg gagccggaga aaaagtcgtg gttctcccct gcaccggggt
2224321 cgagagctgc gcgcacggcc gggttcacct ggcaggtgtc acgatcgaat gcaggctggt
2224381 atcccaggtt ggctagcgcc ttgttggcgt tgtaacgcat gtagggcaaa acgtcgtcgg
2224441 tccagcccaa ctcgtcgtac aagtcgtgcg catagtcgat ctcgttcgcg tagagcgtgt
2224501 gcagcagctc gcaggtgtat tcgcggtggt cggcccgctc ggcgtcggtc aggtcggcca
2224561 aacctcgttg acatttgtag ccgatgtagt agccgtggac ggcttcatct cggatgatca
2224621 gccggatcag atcggcggtg ttggtgagct taccccgcga cgaccagtac atgggcaggt
2224681 agaagccgga gtagaacagg aaggactcca gcattaccga cgatgctttg cgcttgagcg
2224741 cgtcgtcacc gcggtagtag tcgacgatga tctgcgcttt tcgctgcagg taagggttct
2224801 gttccgacca gtcgaaggca tcgtcgatct gcttggtcga gcacagggtc gagaagatcg
2224861 agctgtagct cttggcgtgc actgactcca tgaacgccat gttggtcagg accgcctctt
2224921 cgtggggggt gaccgcgtcg tcgatcatgg ccactgctcc caccgtcgcc tgcgcggtgt
2224981 cgagcagggt caagccggtg aacacccgga tcgtcgtctg ctgctcggtg gaactcaacg
2225041 tttgccaaga tgccaggtcg ttggagagcg gaatcttttc cggcaaccaa aagttaccgg
2225101 tcaaacgttc ccagacctgc aaatctttag catcgagcaa ccggttccaa ttgattgcgt
2225161 gcacccgctc aacgagcttg ccggtcatcg agggccgtcc tgccttgcca tggtcatgcc
2225221 gctgttggcc ggtgcgtacg ctcctgtggg cgtcaagtcc ggcagtcggt ccttgggcat
2225281 ttcggccgtc ctccttgtca ttgacggtct ttcatggcgt gcaccagcac tgtagcttag
2225341 tgatttcggc tacccatatt ttattcttcg tgtcgctgaa ctcattacaa acagcgatca
2225401 ccgcgcatac ggttacgcga cgcctggcca gtagccgacg acgccgcgga actcaaggtc
2225461 ggtttgcggg aagtcgttgc cgacggccag cagtggttgg tggcccagct gggcggtcgc
2225521 gtacgtcata cagtctccga agttgagagc cgcgcggtgg cgccccttgc cgtatcgcag
2225581 aaaggctcgt tgcgtggcag cggcatgctc ggcggtgaaa gatgacacgc tcaagccgat
2225641 ttcgctgcga agtcgttcga agatcgtgcg cgcaacgggg ccgtgacggg cggtcaagac
2225701 aatcaggcat tcggcgacgg tgggtgcaga catgacgggg ctatgggcgc cggccagggc
2225761 ggccgcgacc agggtggcgt gcggccgctc gccttgaacc agggccacca cggcgcttgt
2225821 gtccacgatc attgcggtgc tcagactccg gttgcggggt cgtagccgag gatttgttcg
2225881 cgctcgagct tggtgatggg ggagcggtcg gcaagcaggg gccagatttc ggtacgcaag
2225941 atgtcgagaa gttgtgcctc acggtcgccg gcgcgcgact ccaaaaacgc cagctgggca
2226001 gacagggcat gccggatggc ggcagtcttg ctggtgtgca gccggtcagc gagttcggcg
2226061 gctagtcggt ctacctcagg gtctttgata ttcagcgcca caggtagatg gtaccagcaa
2226121 atagccacta tctacctaac gcgtgctgtg ccgtgcggta gctactgaaa atccgagatg
2226181 tcaaaggcag cgtctggata cgctgtatgc gcgcagggat ggtgatcgag gcggaggggc
2226241 ggcgtgtcat ttctggtcgt ggttcccgag ttcttgacgt ccgcggcagc ggatgtggag
2226301 aacataggtt ccacactgcg cgcggcgaat gccgcggctg ccgcctcgac caccgcgctt
2226361 gcggccgctg gcgctgatga ggtatcggcg gcggtggcag cgctgtttgc caggttcggt
2226421 caggaatatc aagcggtcag cgcgcaggcg agcgctttcc atcaacagtt cgtgcagacg
2226481 ctgaactcgg cgtcaggatc gtatgcggcc gcggaggcca ccatcgcgtc acagttgcag
2226541 accgcgcagc acgatctgct gggcgcggtc aatgcaccaa ccgaaacgtt gttggggcgt
2226601 ccgctaatcg gcgacggagc acccgggacg gcaacgagtc cgaatggcgg ggcgggtggg
2226661 ctgctgtacg gcaacggcgg caacggttat tccgcgacgg cgtcgggggt cggcggcggg
2226721 gccggcggtt ccgcggggtt gatcggcaat ggcggcgccg ggggagccgg cggacccaac
2226781 gcccccgggg gagccggcgg caacggtggc tggctgctcg gcaacggcgg gatcggcggg
2226841 cccgggggcg cgtcgagcat ccccggcatg agtggtggag ccggcggaac cggcggtgcc
2226901 gcaggacttt tgggctgggg agcgaacggc ggagccggcg gcctcggtga tggagtcggt
2226961 gtcgatcgtg gcacgggcgg cgccggaggc cgcggcggcc tgttgtatgg cggatacggc
2227021 gtcagtgggc caggcggcga cggcagaacc gtcccgctgg agataattca tgtcacagag
2227081 ccgacggtac atgccaacgt caacggcgga ccgacgtcaa ccattctggt cgacaccgga
2227141 tccgctggtc ttgttgtctc gcctgaggat gtcgggggaa tcctgggagt gcttcacatg
2227201 ggcctcccaa ccggattgag catcagcggt tacagcgggg ggctgtacta catcttcgcc
2227261 acgtatacca cgacggtgga cttcgggaat ggcatcgtca ccgcgccgac cgccgttaat
2227321 gtcgtcctct tgtccatccc aacgtccccc ttcgccattt cgacctactt cagcgccttg
2227381 ctggccgatc cgacaacaac tccgttcgaa gcctatttcg gtgccgtcgg cgtggacggc
2227441 gttctgggag ttgggcccaa tgcggtggga ccaggcccca gcattccgac gatggcgtta
2227501 ccgggtgacc tcaaccaggg agtgctcatc gacgcacccg caggtgagct cgtgttcggt
2227561 cccaacccgc tacctgcgcc caacgtcgag gtcgtcggat cgccgatcac caccctgtac
2227621 gtaaagatcg atggtgggac tcccataccc gtcccctcga tcatcgattc cggtggggta
2227681 acgggaacca tcccgtcata tgtcatcgga tccggaaccc tgccggcgaa cacaaacatt
2227741 gaggtctaca ccagccccgg cggtgatcgg ctctacgcgt tcaacacaaa cgattaccgc
2227801 ccgaccgtca tttcatccgg cctgatgaat accgggttct tgcccttcag attccagccg
2227861 gtgtacatcg actacagccc cagcggtata gggacaacag tctttgatca tccggcgtga
2227921 tcgagcctgt tcgccgcgaa tgtcgccgcc tggcttgtca tccccgactg aacatacgaa
2227981 acatgcgcca taatattgcc gcctccggtg catattggat cgtcgggagc acacaagttt
2228041 atggtcttag agctatacag cggaccgatt gtcggcaacg acccgccgcc ccacaacatg
2228101 ctggagaaac cactggatgg ctcgccgaaa agggcgacag cggcgacatg atctgccacc
2228161 gcgggcggca tcgccgaggt ggacaaatcg atgaccgtcg caccctgcga atagccacca
2228221 agcacaatcc tggtgttcgg gcagctggcg acggtgcgct ggatgtgggc gctcgcatca
2228281 tcggaaccgt ttgacgcgct cgcgcggtag tcgtcgcttg ctgggtagtt caccgcgtag
2228341 accccaatcg accgcccgcc aacttgcgag gtaagcgagt cgacgaacgc ctcaccgacg
2228401 tcgccaagac cagaagcctg atgcgtgccg cgagcgaaaa cgaccgcgat gtccgaacac
2228461 ggatccgcat gcgcggcacg accgccggcg ggtgcgctca ccagcgccaa ggtcgtcgca
2228521 accacgacac caacgatgcg aacaaggctg cgtggagtca tctgcacatg ctgacatact
2228581 gccggcgacc gaggtggcgg tgggccgctg agacatgacg tgcctcacgt cgtcggcgcc
2228641 cacgcagccc caggtcagaa cggtagcctt aggcgatgac cgactctgtg gtcgtccgcg
2228701 tcaagcccgg cagtcacaaa ggacccctgg tcgaggtcgg tcccaacggt gagctgatta
2228761 tctacgtccg cgagccggcg attgatggca aggccaacga tgcggtcacc cggctgctcg
2228821 cagctcacct tcaattgcca aagagccgag tcaaattggt gtccggagcg acgtcgcggt
2228881 tcaagcgttt ccgtctgagt cgttaagttc aacctgtttg aggaagcggg tccagcaagg
2228941 ccgggacatc gagaccaagc cgcgctaaca caacaacatg ctggcgtcgg tcaacccggt
2229001 cggcggcggc gttgctggcc ccggtacaga ccgcttgccg ccgccctcac cgtgtcggta
2229061 attcgcgcga tgatcggact gtccagtttc cagcattgcc aatagagagg gacgtcgagg
2229121 tgtatgtcgc agacccgtac gaacgatcca tcggcaagcg gagatgctgc cagcttctcg
2229181 gggaacatgc cccatcccag cccggcgcgc gctgcggcgg tgaagccctc tgtggtcggg
2229241 acaaagtgcg tcggtctggt gatggcgcga cgaaaggcct tacgcaccaa catgtcctgc
2229301 agcccatcgt cacgattcca cgccagtgac ggagctttag ccgccgcggc ggcagtgaac
2229361 ccgtcggata gatggcgctg gacgaatggc ctgctggcca ctggtaggta gcgcatttca
2229421 cccagcgggt gcacccggca gcccggcacc gggttccgct cggtggtcac cgcgcccatc
2229481 gccacaccct cccgtagcag ccgcgcggaa tggtcctggt cctcgatccg aacgtcgagc
2229541 aggacgtcgc cgagaccgtc gaacacggcc gaaaaccatg tcgccatgga atcggcgttt
2229601 accgcaatgg tgatccgcgt gcgtttcagc gacgcgttgc cacccatttc agcgagcgcc
2229661 tcggactcga gcaacgctgt ttgcgcggcc aaccgcaaca gcgggatacc tgcggtcgtc
2229721 gcccgacatg gcttttccct gaccaccagc acctggccga cctgctgctc caacgacttg
2229781 atgcgctgac tgacagccga cggggtgaca tgtaggcgct ccgcggccgc atcgaagctg
2229841 cccagttcga ccacggcagc caatgcggcc agctgtggac cgtcaagctg cggatccacc
2229901 atctcaggtg tagaccatct gcggagcgtc gcactgcaca ttaataatgc taatgtaaat
2229961 gaagaattat tagctatact gacccataca aactgcctag tgtcgattgc gtgaactcac
2230021 cactggtcgt cggcttcctg gcctgcttca cgctgatcgc cgcgattggc gcgcagaacg
2230081 cattcgtgct gcggcaggga atccagcgtg agcacgtgct gccggtggtg gcgctgtgca
2230141 cggtgtccga catcgtgctg atcgccgccg gtatcgcggg gttcggcgca ttgatcggcg
2230201 cacatccgcg tgcgctcaat gtcgtcaagt ttggcggcgc cgccttccta atcggctacg
2230261 ggctacttgc ggcccggcgg gcgtggcgac ctgttgcgct gatcccatct ggcgccacgc
2230321 cggttcgctt agccgaggtc ctggtgacct gtgcggcatt cacgttcctc aacccacacg
2230381 tctacctcga caccgtcgtg ttgctaggcg cgctggccaa cgagcacagc gaccagcgct
2230441 ggctgttcgg cctcggcgcg gtcacagcca gtgcggtatg gttcgccacc ctcgggttcg
2230501 gagccggccg gttgcgcggg ctgttcacca accccggctc gtggagaatc ctcgacggcc
2230561 tgatcgcggt catgatggtt gcgctgggaa tctcgctgac cgtgacctag tacagcacgt
2230621 gtgcacacgc gggttggacc acgtgatcgt cgatgggcac ataccgttcg gcaggagggc
2230681 gcgcggtcag tctgcacaac tcagtcacca gctgacacgc cgacggcggc ctcgcccggg
2230741 cgtgtcggcg ccaccagtgc acattcggcg tgacgcggcc ctacggatcg tgttggagct
2230801 gtagcccgtt gataccggtc gcgaacggtg aacggcgcta atcgggggag tggggtcgag
2230861 gctgtctggc cttccccgtc cgcaagttcg cgttcggccg ggccgatatc tggttcaggg
2230921 tgggtcgagg ccaaatttca tcacggttgc ggttgagcaa agttgctgta gcttgctcgc
2230981 gaggagacgg ccgatatcgc ctcattggca ttagtgttgg ctgtcatggc cggactgaac
2231041 atttacgtga ggcgctggcg gacagcgctt cacgcaaccg tgtcggcatt gatagttgcc
2231101 atcctcggac tcgccatcac cccggtcgct agtgcggcga cggccagggc gacgttgtcg
2231161 gtgacatcga cgtggcagac cggtttcatc gcccgcttca ccatcacaaa ctcgagcacg
2231221 gcgccgctaa ccgattggaa gcttgaattc gacttgccgg caggagaatc cgtcttgcac
2231281 acatggaata gcaccgttgc acgatctggc acgcactacg ttctcagccc agcgaattgg
2231341 aatcgcatca ttgcccccgg tggttcagcc acgggcggcc taagaggcgg gctgaccggt
2231401 tcttactcgc cgccgtcgag ttgtctgctc aacgggcaat atccttgcac ctagacgcga
2231461 ctgcgcactg aggctcgccg actgcaacaa tgcggctact gccaggtggg tctagtgggt
2231521 cgtcacggcc aacgtcatct cggagttgat gcggacggcg ccagagccct ggggctggtg
2231581 atgaccagaa ggttgcctga accgagaaat tggattgatc gcagtgccgg tggcgggcta
2231641 cggtcgggcg cgtgggcatc tacgcagtga cggtacgtcg tgtccgccct cggacggtcg
2231701 cgacgggcat ggggctggca ccggctccat gacgaatggg cagcgcgggt agtcagcgcg
2231761 gccgcagtgc ggcccggtga gctcgtgttt gacatcggcg ccggcgaagg ggcactgacg
2231821 gcgcatctag tgcgagcggg ggcgcgggtg gtcgccgtgg agttgcaccc gcgacgagtc
2231881 ggtgtcctcc gcgagcgatt ccctggcatt accgtggtgc acgcggacgc cgcctcgatc
2231941 cggttgcccg gccggccgtt ccgggttgtg gcgaacccgc cgtacgggat ttcgtcccgc
2232001 ctgctgcgga cgctgctggc acccaacagc gggcttgtcg cggccgatct cgtgctgcag
2232061 cgagccctcg tatgtaaatt cgcttctcgc aacgcgcgaa ggttcaccct gaccgtcggc
2232121 ctcatgctgc cacggcgcgc gttcctgcca ccgccgcatg tggattccgc ggtgctcgtc
2232181 gtccgccgcc ggaagtgcgg tgactggcag gggcggtaaa cccgcggccg ccagtaggtg
2232241 taccaccttt gctagaagtg gcacacttcg ttctatgtcg accactcgtc cgcgctacca
2232301 aataaccgaa accccggagg tagctcaggc attggaccgg gccgcccagc gatggcctgg
2232361 cgagccccgt tccaaattat tgcggcgcct gatcatcgat gctcgacgat ccgcgttccg
2232421 cgggtagcgt cgttgcgccg tacgacgatg gcgagctgct gcgtctcgcc gaactacgcg
2232481 ctagcagcgg gctaaaacta cctgattgct gcgtgccgga tgtggcaatt catcaccagg
2232541 caagcctcgc aacctttgac gacacgctcg ctgccgcagc acgcacaagg agcgtgcccg
2232601 ctagcacaaa cggcgcagct aacccaatac gaccagcttc acttgacata atgtcgctta
2232661 tcggcttata agtgatgcga gttgctcctt acgatgacca tggcacagcg gcatccttct
2232721 ctgcgccaag ctggccagct acgtggctcg aagttcttgg taaagagcag gcgtcagatc
2232781 gacgctttgt cgcagttgta gttggcccgg ccgagttcgc tgttcatacg cggtgacaac
2232841 gaggccgaca ccgcccgccg ccggcacgag gacaccttgc atgtgcaaga accaggccgc
2232901 atgtccgacc gcctggcacc ctgaccagtc gtcgccatag atgtcgtcgt tctcgagccc
2232961 cacggcttcc cgagcttgcg gggttgtcag atcgaggacg gccaggtccg tgacgtcgat
2233021 cgtgtgtagt cggtaggccg cctcgagcat cttctctgcg gtcgttgaag ccgcttgcgc
2233081 cgcccgttcc acctcaacca tgcaggcttg ggcggaatca gcaagataga tcgccggaaa
2233141 gagcagcggc ggattccacc tgcctccgaa tctgcgcgcg ccctcaccgg acaaggcgtc
2233201 acggtgcgcg ccggtatacc ggtagcacgt ttccgaccac tcaattgttc cgcgtgcgtc
2233261 gatacgctgg acgagccctt catcgagggc atcgctcaca cgaacactcc ctccgccatc
2233321 gcgtcgatga gcgccaacac gcgttggtac tcgccgtctc gcacgaggtc ggcaggcttg
2233381 cggtgttcca gtaaccgatt cggcgaaaac atccacacgt tcgcctggtc acgcggcagc
2233441 acttccgcga gggcgtcggc gacataggcc agctcgataa gtcgttgctt gttgaggcgt
2233501 tggggaacca cctgacctgc ggtccatcgc gccacggaac gcggcgaggc atcgacgatg
2233561 tcaccgactt cctcgtaggt caatcccaag cgctcgatcg cacccgacac ggtcgaggcg
2233621 agcacattta ctcccatggg cagcctgtct tccttttgtc tattgatttg tcatgtatta
2233681 tgacacgaac cgaggcgtcg atgcgagagg aacttcacga cgatgggcat tcagtttcgg
2233741 ctcgggccgg gtgatcacaa accggtcgag gacttcctgt cccgcgacca cgccggcacc
2233801 actgcgatca cgctggacac caacgccact cgtcaccagc acgacgctgc cgcagccgca
2233861 gtcgacgcag gcctagatgt ctactgggag ccagcagccg agcgcctcgc cgcgcacccg
2233921 gcttcgggct cgacaagttc cctctgtgaa acgggcagcc ctacgacacg gatgccctga
2233981 cgcgcgacgc ggcggcacgc gccgaactcg tcggcaggac tctcgacaaa cacccgtcga
2234041 tcgtcacgca cgtcacggcc ccacacttct acctcaccaa cgagcgcacc gcacgcctca
2234101 acatcgacct tgccgagcgc acgcgcttgg ccgtcggcta ggcggaccgc atgcgaacgg
2234161 ccttgacccc gagccacgcc cgtaatgaat gcaaccttgc cctcaagcct gcccacaaca
2234221 ccacctccgg cgagtagttc ccccggcggg ggggcttaca ccaagcagga acgtcaccgt
2234281 gacgaattgt cgcgtggcgc agtgtcaaag gtccagtacg cgacgaagtc ctcggtcaac
2234341 ctcgtgcatc aagctcgctg gcacctcccc aactcggtcg gtgaggtcag tcttgttgag
2234401 cgtgacaatc gccgtgacgt tgacgaccga gtcacgtggc agtcgcgttg tggtcgcggg
2234461 caagaacacg ttgccgggca ttgccgccag cgccgtattg gacgtgatca ccgctgcgat
2234521 cacagtggca aggcgacttg cgttgtacgg atctgactgg attacgagca ccgggcggcg
2234581 cttcgccggc tgactgcctg atggcggccc gaggtcagcc cagtagatct cggcacgact
2234641 aatcaccact catcgtccat ggtttctagc acgcggtatg cgttggccac ggcgagggcc
2234701 tccgcttcgt cggtgccatg gatgctctct agagccctgt cgatctggcc cgtgagcaat
2234761 tgggcgtcca gctcgtgcag gtagcgctgc gcagccttcg tgaagaactc ggaccgactc
2234821 atgccgagct cactcgcacg ccgcgatacc cgatcgaacg tctcatccgg cagagaaata
2234881 gctgtcttca tacagatagt ataaccgggt ataacttcca gaagacggcg gctgtttcgt
2234941 cacagtgacg ctattgctgg tccaaacaca ctccacgatt ccgcgcgtcg ctaccccggg
2235001 atagtccgat caggtgtctt gggtggcccg gcaagtggtt tgatgcgtcc ggcccgcacg
2235061 ccgttggcga tgacgatgac ctcggtgaac tcgtgcacaa gcacgaccgc ggccagtccg
2235121 aggatcccga acaacgccag cggcatcagc acggtgatga tacttaggga caatccgacg
2235181 ttttgcacca tgatctgccg cgagcgccgg gcatggtcta gggcttgggg cagatgccgc
2235241 aggtcttggc ccatcagggc gacgtcggcg gtttcgatgg cgacgtcggt tcccatggcg
2235301 cccatcgcga ttcccaggtc ggcggcggcc agggccggag cgtcgttgac tccgtcgccg
2235361 accatcgcgg tgggttgccg agcccgcagc tgtgcgacca gatgagcctt gtcctcgggc
2235421 cgcaattcgg catgtacctg ctcgatgccg gcttgggctg ccagggcggc agcggtggca
2235481 tggttgtcgc cggtgagcat cgtcacctgg tagccgccgg tgcgcagccc ggccaccacc
2235541 tcggcggctt ccgggcgtag ttcgtcgcgc acggcgatgg caccaagcag ctgctggtcg
2235601 cgttcgacga gaaccgctgt ggcgccggct tgttgcatgc acgccacatg atctgcgagc
2235661 tcggcggcat cgagccagcc gggtcgcccc agtcgcacca cccgcccgtc gaggcggcct
2235721 atcagcccgg cgcccgggac ggcttgcacg tcgctggcgg cggtcgtcgc ttgggtcgcg
2235781 gcaagcacgg ccacagccag gggatgttcg ctgcgggctt ccagggcggc tgccaccgcc
2235841 aacacttcct cgcgggtagc gccgtttgtg gtggcgacgt cgatgacgac gggccggttg
2235901 gcggttaacg taccggtttt gtccagggct accgcgcgga tggtgcccag ggtttccagc
2235961 gcggcgccgc ccttgatgag cacgccgagt ctggaggcgg cgccgatgga cgcgaccacg
2236021 gtgaccggaa cggcgatggc cagcgcgcac ggggcggcgg cgactaatac cacgagcgcg
2236081 cgttcgatcc agaccagcgg attacccaag acgctgccgg tcccggcgat cagcgccgcg
2236141 gcgatcatga tgctgggcac caacggtcgc gcgatacagt cggctagccg ctgactagca
2236201 ccttttcgga cctgttcggc ctccacgatg tgcacgatgc gcgccagcga gttgttggcc
2236261 gcggtagcgg tgacccccac ctgcagcacg cccaagccgt tgatcgaccc ggcgaacact
2236321 tcgtcaccgg gtccaacctc gaccggcacc gattcgccgg tgatcgcgga gacatccagg
2236381 gcggtgcgcc cggcacgaat gatgccgtcg gtggccaggc gttcgcccgg tttaacgatc
2236441 atctggtcac cgacgtgcaa ttcggttgag gccacgatgg tttcggtgcc ctcccgcaga
2236501 actgtggcct gatccggcac cagcgacagc agggcgcgca ggccacggcg agtgcgcgcc
2236561 gtcgcgtatt cctccaagcc ttcgctgatc gagaacagaa acgccagcgt agcggcctca
2236621 cccagctcgc caagtgcgac agcgcccagc gcggcgatgg tcatcagggt gcctacgccg
2236681 acgcggcctt cggccagtcg tttgaggctg gagggcacga atgtcgaggc cccaaccgcc
2236741 agcgcaaggg ccttcagtcc cagtacgacc ggccacagcg gataagccca tgcggcaact
2236801 agcgacgcgg tcagcaacac tccggagaat gcggctcgcc gcagtttggc gacttgccag
2236861 agctgctccg gctcgcggtc ctcgttgtcc tcgccgtcgc agcaggcatc gctcgtctcc
2236921 cccgatggct gcgcggccac gtcacgccga actcctgata gtgttcgcgt gctccagtcg
2236981 atgattttct gcactacccc ggccttgcgg ttactggccg agcgcgaagc atacgcgggc
2237041 accgccgccg cagggacggt ctcggcatcg atgattgccg acaggatggc agcggtgtcg
2237101 cagattgcgc gtgaatacca gatcacaatg gatgccgtcc gcggataggc atgcacggcc
2237161 tgcacaccgg ccaccttgcc gacggtgtcc tcgatcgcaa cggcccgtcc cgcgtcgaac
2237221 tgaaacccgg tggcctgcac acgcatccgc ccggctgcat cggatacaac ggtcagctgg
2237281 acctcggcgt caactacagt cgtcactcgt cgaccctggc gccagcgggc aggggcgcct
2237341 cctcaccgat gcgcccgcga gcctcggcaa cgacgtcggc gactgtcagc cgggccgact
2237401 cggccgccgc ctccgcgcgc cgggttccgc gcaggcccca ctccatcacg gtcaccgacg
2237461 cccggcgaat gggcgccgta cccagcgctt tgcgcagcgt ttcgtaggcg ctcaccccga
2237521 ccagtccggt gagcaccgcc ccggccgcct taaccaatag ctcatgcgta accacggtca
2237581 gttctccttt gctttgtcct gtaaccacaa gtcgtgtcgt ctgctgctca gctacctgtc
2237641 atctcgaccg cctccccgga cgcggcgcgc tcggcgacac agggttggtc ggtatccacc
2237701 gcgagaacga cctggaccaa ctcgcccaag gctcgcgcca ggtgactgtc ggccagcgca
2237761 taccgaacct gccggccctc ataggttgcg actaccagcc cgcagccccg caaacacgac
2237821 agatggttgg acacattcga tcgggtcaac ccgaggtgcg cagctagctg gccgggatag
2237881 caaacgccat ccagcaacgc caccagaatc cggcaccgcg tcggatcagc cagagcccgg
2237941 ccgagtcgag ccagggccga ttcccgcatc tcacacgtca gcatagatca aatagtacac
2238001 catatactgg tataacagca agagctgaat tgtacatcca tagcagatat gatcggcgcg
2238061 cgtcacaagc ttccggccgc agagccgcca actcacgata tcgttaaccg atatcccgag
2238121 ccgatagctg gcgggctcgg gtggtggcca gcggcgctgc gacgaaaggt gtgaccgtca
2238181 tgaaacagac accaccggcg gccgtcggcc gtcgtcacct gctcgagatc tcagcatccg
2238241 cagccggtgt gatcgcgctt tcggcgtgta gtgggtcgcc gcccgagccc ggcaaaggcc
2238301 ggcccgacac aaccccggaa caggaagtcc cggtcaccgc gcccgaggac ttgatgcgcg
2238361 aacacggagt gctcaaacgc atcctgctga tctatcgcga ggggatccgc cgcctccaag
2238421 ccgatgatca gagtcccgct ccagcactga acgaaagcgc gcagatcatt cgacgcttca
2238481 tcgaggacta ccacggacag ctggaagagc aatacgtctt ccccaagctg gaacaagccg
2238541 gcaagctcac ggacatcacc tcggtcttgc gcacccagca tcagcgcggc cgggtgctca
2238601 cggaccgggt actcgccgcc accactgcag cggctgcatt cgatcagcct gcgcgagaca
2238661 ccctggccca agacatggca gcgtacatcc gaatgtttga gccgcatgag gcgcgcgagg
2238721 acacggtcgt tttcccggcg ttgcgcgacg tgatgtccgc tgtcgagttt cgcgacatgg
2238781 ccgagacctt tgaagacgag gagcaccggc gctttggcga ggccggtttt caatcggtgg
2238841 tcgacaaggt cgccgatatc gaaaaaagcc ttggcatcta cgacctgagc cagttcaccc
2238901 ccagctaaag acactaatgc ccttgggtta gggaccatcg cctcctgacg cgatcgcgac
2238961 agctggctaa cgtcggtagt acacccatgc agaggggacg ccaatgtcag cccaacaaac
2239021 gaacctcgga atcgtggtcg gtgtggatgg ttcaccctgc tcgcatacgg cagtcgaatg
2239081 ggccgcgcgc gatgcgcaga tgcgcaacgt tgcgctccgc gtggtgcagg tcgtgccccc
2239141 ggtaataacc gccccggaag ggtgggcatt tgagtattcg cggtttcaag aagcccaaaa
2239201 gcgcgaaatc gtcgaacact cgtacctggt cgcccaagcg caccaaatcg tcgaacaggc
2239261 ccacaaggtc gccctcgagg catcctcctc aggtcgcgcc gcgcaaatca ccggcgaagt
2239321 gctgcacggc cagatagtgc ccacgctggc caacatctcc aggcaggtcg cgatggtcgt
2239381 gctgggctac cgaggtcagg gcgccgtagc cggcgccttg ctgggatcgg tcagctcaag
2239441 cctggttcgc cacgctcatg gccctgtcgc cgtaataccc gaggagccgc gaccggcgcg
2239501 cccgccgcac gcgccggttg tggtgggcat cgacggctcg cccacctcgg gattggcggc
2239561 cgagatcgcc ttcgacgagg catcgcgccg cggcgtggac ttggtggcgc tgcacgcgtg
2239621 gagcgacatg ggccccctcg actttcctag gctcaattgg gcgccgatcg aatggagaaa
2239681 cctcgaagac gagcaggaga aaatgctcgc ccggcgtctg agcggatggc aagaccggta
2239741 tcccgatgtc gtcgtgcaca aagtcgtggt gtgcgatcga ccggcacccc gcctgctcga
2239801 attggcacaa accgctcagc ttgtggtggt tggcagccac ggccgcgggg ggttccccgg
2239861 catgcatctc ggctcagtca gcagagcggt ggtcaattcc ggtcaggctc cggttatcgt
2239921 cgcccgaatc ccccaagatc cggcagtgcc ggcctgaggg cctgtgcgat ctgctcgggt
2239981 ggtgcccacc cgcgcggaaa gccccgtccg aaccgtgatt gggcaacgtc gggccgggcc
2240041 agcagcgctg gaccgtaggt ccctgcagtg gatgacttac ggccctgatc cacaccggcg
2240101 accgttaggc agggttgagc caaccgtcgg ttgagcgtct ggctgcgagg tgaggtgatt
2240161 gtcggcgtca gtgtctgcca cgacggctca tcatggcttg ccagcacatg aagtggtgct
2240221 gctgctggag agcgatccat atcacgggct gtccgacggc gaggccgccc aacgactaga
2240281 acgcttcggg cccaacacct tggcggtggt aacgcgcgct agcttgctgg cccgcatcct
2240341 gcggcagttt catcacccgc tgatctacgt tctgctcgtt gccgggacga tcaccgccgg
2240401 tcttaaggaa ttcgttgacg ccgcagtgat cttcggtgtg gtggtgatca atgcgatcgt
2240461 gggtttcatt caagaatcca aggcagaggc cgcactgcag ggcctgcgct ccatggtgca
2240521 cacccacgcc aaggtggtgc gcgagggtca cgagcacaca atgccatccg aagagctggt
2240581 tcccggtgac cttgtgctgt tagcggccgg tgacaaggtt cccgccgatt tgcggctggt
2240641 gcgacagacc ggattgagcg tgaacgagtc agcacttacc ggcgagtcga cgccggttca
2240701 caaggacgag gtggcgttgc cggagggcac accggtcgct gatcgtcgca atatcgcgta
2240761 ttccggcaca ttggtaaccg cgggccatgg cgccgggatc gtcgtcgcga ccggcgccga
2240821 aaccgaactc ggtgagattc atcggctcgt tggggccgcc gaggttgtcg ccacaccgct
2240881 gaccgcgaag ctggcgtggt tcagcaagtt tctgaccatc gccatcctgg gtctggcagc
2240941 gctcacgttc ggcgtgggtt tgctgcgccg gcaagatgcc gtcgaaacgt tcaccgctgc
2241001 gatcgcgctg gcggtcgggg caattcccga aggtctgccc accgccgtga ccatcacctt
2241061 ggccatcggc atggcccgga tggccaagcg ccgcgcggtc attcgacgtc tacccgcggt
2241121 ggaaacgctg ggcagcacca cggtcatctg cgccgacaag accggaacgc tgaccgagaa
2241181 tcagatgacg gtccagtcga tctggacacc ccacggtgag atccgggcga ccggaacggg
2241241 ctatgcaccc gacgtcctcc tgtgcgacac cgacgacgcg ccggttccgg tgaatgccaa
2241301 tgcggccctt cgctggtcgc tgctggccgg tgcctgcagc aacgacgccg cactggttcg
2241361 cgacggcaca cgctggcaga tcgtcggcga tcccaccgag ggcgcgatgc tcgtcgtggc
2241421 cgccaaggcc ggcttcaacc cggagcggct ggcgacaact ctgccgcaag tggcagccat
2241481 accgttcagt tccgagcggc aatacatggc caccctgcat cgcgacggga cggatcatgt
2241541 ggtgctggcc aagggtgctg tggagcgcat gctcgacctg tgcggcaccg agatgggcgc
2241601 cgacggcgca ttgcggccgc tggaccgcgc caccgtgttg cgtgccaccg aaatgttgac
2241661 ttcccggggg ttgcgggtgc tggcaaccgg gatgggtgcc ggcgccggca ctcccgacga
2241721 cttcgacgaa aacgtgatac caggttcgct ggcgctgacc ggcctgcaag cgatgagcga
2241781 tccaccacga gcggccgcgg catcggcggt ggcggcctgc cacagtgccg gcattgcggt
2241841 aaaaatgatt accggtgacc acgcgggcac cgccacggcg atcgcaaccg aggtggggtt
2241901 gctcgacaac actgaaccgg cggcaggctc ggtcctgacg ggtgccgagc tggccgcgct
2241961 gagcgcagac cagtacccgg aggccgtgga tacagccagc gtgtttgcca gggtctctcc
2242021 cgagcagaag ctgcggttgg tgcaagcatt gcaggccagg gggcacgtcg tcgcgatgac
2242081 cggcgacggc gtcaacgacg ccccggcctt gcgtcaggcc aacattggcg tcgcgatggg
2242141 ccgcggtggc accgaggtcg ccaaggatgc cgccgacatg gtgttgaccg acgacgactt
2242201 cgccaccatc gaagccgcgg tcgaggaagg ccgcggcgta ttcgacaatc tgaccaagtt
2242261 catcacctgg acgctgccca ccaacctcgg tgagggccta gtgatcttgg ccgccatcgc
2242321 tgttggcgtc gccttgccga ttctgcccac ccaaattctg tggatcaaca tgaccacagc
2242381 gatcgcgctc ggactcatgc tcgcgttcga gcccaaggag gccggaatca tgacccggcc
2242441 accgcgcgac cccgaccaac cgctgctgac cggctggctt gtcaggcgga ctcttctggt
2242501 ttccaccttg ctcgtcgcca gcgcgtggtg gctgtttgca tgggagctcg acaatggcgc
2242561 gggcctgcat gaggcgcgca cggcggcgct gaacctgttc gtcgtcgtcg aggcgttcta
2242621 tctgttcagc tgccggtcgc tgacccgatc ggcctggcgg ctcggcatgt tcgccaaccg
2242681 ctggatcatc ctcggcgtca gtgcgcaggc catcgcgcaa ttcgcgatca catatctacc
2242741 cgcgatgaat atggtgttcg acaccgcgcc aatcgatatc ggggtgtggg tgcgcatatt
2242801 cgctgtcgcg accgcaatca cgattgtggt ggccaccgac acgctgctgc cgagaatacg
2242861 ggcgcaaccg ccatgatgcc ccgtccgtga gtacggtgtg cgtgcggtcg atccggccag
2242921 agttaccagg tcggaactag ccagttacgt tgtactcgtg cggttctcgt agtcaaccaa
2242981 gcgtgcctgc agttcggcgt acggtacgga ccgtggcagc tgctctccgt cgctcacggc
2243041 ccgagccgcg tgggccgctg catacaaccc cgcgctgtag ggcactgaac cggttgacac
2243101 ccgggccacc ccgagctcac caaggtcggc gatcgtcaag ccgggcacgg gcaacgtgtt
2243161 aaccgggcac ggaatgttgc gagtgagctc agcaagttcg tcgggatcgt tggccagtgg
2243221 gacaaagacg ccgtcggcgc cggcatcgac gtagcgaagt gcgcgctgga tcgtgctggt
2243281 ggtatcggcg tgctggcgca accaataggt gtcgacgcgg gcgttgacga acacctcggg
2243341 gttacgttgt ttgatcgcaa cgattttagc ggctgccagg gcggggtcga tgagcttttc
2243401 ggcgctactg tcctcgatat tgattccggc tgtcgacagt tgtgcgacgt agtcagcaat
2243461 ggcgtcgggt tcgtcgctgt atccgtcctc gatgtcgacg ctgacgtagc attgcagcgg
2243521 tgccagggcg gccgccagtg cgatgttggc gccgcgagtg gcgcggtgcc cgtccgggtg
2243581 cccgccgctg gacgagaccc cgaaactggt tgtgccgata gccgtgaagc cctccgcgag
2243641 gtaggccagg gccgacggca catcccaggc gttgggcaac acgaacggaa caccttggtg
2243701 atgaagatcg tggaaactca ttccctacct ccctgctggc ggatgggcct gattgtatgt
2243761 gtgacccgcg tcagcagggt cagtcggtga gacccgtcgc cgctggccga ttcaactagg
2243821 ttgcggacgg atgaccactt cgttgggtat caccagaatc agtctgtcgt gctcgacgag
2243881 tgatgatgcg gcgcacaccg tatgccgcca caccgacacc gagcaccgcg gccccggcgg
2243941 ccaccgagga gagtggcagc gcgaacgcca ggactacgca gccgatcagt cccaccagcg
2244001 gaatcaggcg gcggggccgg ccctcgtcga gccccagagt caaggcggag gcgttggcga
2244061 tcgcgtagta gaccagcaca ccgaaggacg aaaagccgat cgcaccacgg atatccgctg
2244121 tcgccgccag cgccgccacc accgcgccaa ccaccagttc ggcacgaaag ggcaccttga
2244181 acctagggtg cacggcggcc agccagcgcg gtaggtgccg gtcgcgtgcc atcgccaagg
2244241 tggtgcggga gaccccgaga atcaaggcca gtagcgagcc caatgcggcc accgcggccc
2244301 ctatctgcac gacgggaatc agccagttca cccccgcgac ccgcatggcc tccgacaacg
2244361 gggcggcggc ccgcgcgagc cgctgcggac ccaacacagc gatcacggcc acggcgacca
2244421 gggcatacac cgccagggtg atgcccagcg ccagcgggat ggcgcgtggg atcgtgcggg
2244481 ccgggtcgcg gacctcctcc cccagcgtgg cgatgcgggc atagccggcg aacgcgaaaa
2244541 acagcaggcc ggccgcctgc agcatccccc agacgtgtgc atctacaccg atatcgagtc
2244601 gcgccgggtc cgcagcgccg gagccatagg cggcgaccac gactgcggtc aagaccacca
2244661 acaccacggc gacgatcgac cgggtgagcc aggcggactt ctgtatcccg gcgtagttca
2244721 ccgcggtcag tgccaccacc acggcgacgg ccaccgcgtg cgcttgcgcg ggccacacat
2244781 agaagccgac cgtcaacgcc atcgccgcac acgatgccgt cttgccgacc acaaagcccc
2244841 agcccgccag gtatccccag aagtcgccca gccgcatccg gccatacaca taggtgcccc
2244901 ccgaggccgg gtagcgcgcg gccagccgcg ccgacgagat cgcattgcag taggccacca
2244961 ccgcggccac tgccaacccg agcaacaacc cagaaccggc cgcgtacgcg gccggggcca
2245021 gggcggcaaa gattccggca ccgatcatgg acccaagccc gatcaccacc gcatccaaga
2245081 gccccagccg tcgccgcagc tcatctggaa tatcgcgtgg gtctagcggg cgtctcatgc
2245141 ctcgataagg ctacggcatc cgatatcggt atacgatatc tacccggaat ttgacgcccg
2245201 agacccgcat gcgtccaggg tttgtgggtt tggggtttgg tcagtggccg gtctacgttg
2245261 ttcgctggcc taaactccac ctgacgccgc ggcagcgaaa gcgtgtcttg catcggcgac
2245321 gattgctcac cgatcgcccg atttcgttgt cacaaattcc aatccgcaca ggagggccca
2245381 tgaacgaccc gtggcccagg ccaacgcaag ggccggcgaa aaccatcgaa accgactacc
2245441 tggtgatagg tgccggagcg atgggaatgg cattcacgga taccctcatc accgagtccg
2245501 gtgcgcgcgt cgtcatgatc gaccgcgcat gtcaacctgg tggacattgg accaccgcct
2245561 acccgttcgt gcggctacac cagccatcgg cctattacgg cgtcaactca agggcactag
2245621 gcaacaacac cattgacctc gtcggttgga accagggact gaacgaactg gcaccagtcg
2245681 gcgagatatg cgcctacttc gatgctgtat tgcagcagca actgctcccc accgggcggg
2245741 ttgactactt cccgatgagc gaatacctgg gcgacggccg gttccggaca ctggcaggca
2245801 ccgaatacgt cgtcaccgtc aatcggcgca tcgtcgatgc cacctacctg cgtgccgtcg
2245861 taccgtcgat gcggccggcg ccgtactcgg ttgcacccgg cgtcgactgc gtcgctccaa
2245921 acgaactgcc caaactcggc acccgggatc gctacgtggt cgtcggtgcc ggcaagaccg
2245981 gcatggacgt ctgcctatgg ttgctccgaa acgacgtctg ccctgacaag ctgacctgga
2246041 tcatgccgcg tgattcctgg ctgatcgacc gagcgacgct gcagcccggg cccacattcg
2246101 tcaggcagtt cagggaaagc tacggtgcga ctctcgaggc catcggggcc gcgacctcga
2246161 ccgacgatct gttcgaccga ctagagaccg ccggaaccct gctgcgcatc gacccctcgg
2246221 tgcgtccgag catgtatcgc tgcgccactg tgtcgcacct cgaactcgag cagctgcgcc
2246281 gtatccgcga catcgtcagg atgggccacg tccaacgcat cgagcccacc acgatagtgc
2246341 tcgacggcgg atcggttccc gccacaccca cggccctcta tattgactgc accgccgatg
2246401 gagcaccaca acgtccagcc aagccggttt tcgacgcaga ccacctaacc ctgcaagccg
2246461 tgcgcggatg ccaacaggtg ttcagcgccg cgtttatcgc gcacgtcgaa ttcgcctacg
2246521 aggacgacgc ggtgaaaaac gaactctgta ccccgattcc acacccggac tgcgatctgg
2246581 actggatgcg tctgatgcac tccgatctag gcaactttca gcgctggtta aacgaccccg
2246641 atctgacgga ctggctgagc tcggcgcggt tgaacttgct cgccgacctg ctgccgccgt
2246701 tgtctcacaa gccgcgggtg cgcgagcggg tggtgtcgat gttccaaaag aggttgggca
2246761 ccgccggcga ccagctagcg aagctgctcg acgccgccac cgcaacaacc gaacaacgct
2246821 aaggatcggc cgtgcaccat aaccgcgatg tcgacttggc gcttgtcgag cgacccagct
2246881 cgggatacgt ctacacaacg ggttggcgac tggccacaac ggacatcgac gagcaccaac
2246941 aactgcgcct cgacggtgtg gcgcgctata tccaagaggt cggtgccgag catctcgccg
2247001 atgcccaatt ggcagaggtc catccccatt ggattgtcct gcgcacggtc atcgatgtca
2247061 tcaacccgat tgagctaccc agcgacatca cctttcaccg gtggtgcgca gcgctttcca
2247121 ccaggtggtg cagcatgcgt gtgcagctgc aaggatccgc cggcggccgc atcgaaaccg
2247181 aagggttctg gatctgcgtg aacaaagaca ccctgacgcc gtcccgtctc accgatgact
2247241 gcatcgcacg tttcggcagc accaccgaaa accaccggct caagtggcgc ccatggctca
2247301 ccgggccgaa catcgatggt accgagacac catttccctt gcgtcgcacg gatattgacc
2247361 cgttcgagca tgtcaacaac accatctact ggcacggtgt gcacgaaata ctctgccaga
2247421 tacccaccct gacggcaccc taccgcgccg tgctcgagta ccgcagcccc atcaagtccg
2247481 gcgaaccgct gaccattcgt tacgagcagc acgacgacgt cgtgcgcatg cacttcgtcg
2247541 tcggcgacga cgtgcgcgcg gcagcgctgc tgcgcaggct ataaccgtct ggacgaatcg
2247601 gcggtatgcc gaccaccatg aaccaaggtc cgcaacgcat cgaagcacga ggagaatcca
2247661 tgtctggacg gttgatagga aaggtcgcac ttgtcagcgg cggggcgcgc ggtatgggtg
2247721 catcccatgt gcgggcgatg gtggccgaag gcgcaaaggt tgtgttcggc gacatcctcg
2247781 acgaggaggg caaggcggtg gccgccgaac tggccgatgc ggcccgctac gtccatctcg
2247841 acgttaccca acccgcgcaa tggacggctg cggtggacac cgcggtcacc gcattcggtg
2247901 gcctgcacgt gctggtcaac aacgccggca ttctcaacat cgggacgatc gaggactacg
2247961 ccctcaccga atggcagcgc atcctcgatg tcaacctgac cggagtcttc ctgggcatcc
2248021 gcgctgtcgt caagccaatg aaagaggctg gtcgcggctc catcatcaac atttcgtcga
2248081 tcgaggggct ggccggcacg gttgcttgtc atggctatac cgccaccaag ttcgccgtgc
2248141 gggggctgac caagtccacc gctctcgagt tggggcccag cggaattcga gtcaactcga
2248201 ttcaccctgg gttggtcaag acgccgatga ctgactgggt ccccgaagac atcttccaga
2248261 ccgcgctggg ccgcgcggcc gaacccgtgg aagtgtccaa cctcgtcgtc tacctggcca
2248321 gcgatgagtc gagctattcc accggcgcgg aatttgtggt cgacggcggg accgtagctg
2248381 gcctggcaca caacgacttc ggtgccgtcg aggtgtcctc gcagccggaa tgggtgacgt
2248441 aaacgccgat tggcaggcaa tgcccgaccg gtctggcgat gacgatcgcg tccgcgctca
2248501 accgcaatcg gatacccagc cggcctgtcc cgcacccggc ccaaggaacg gcgtcgtggt
2248561 ggctattccg actcgagtgg gtgatcatcc ttaggctcgt gcgcttggtc gaccgccgag
2248621 atagcaacga agccggcgcc ggcttggata ccgtcatggg cggcttcgat gtcgtaccgg
2248681 gcgagtcccg gcggttggtg cagcgtgcag cggcgggcga tgacccggaa tcccgagtct
2248741 gcgagcagtt gttcgagttc ggccgcggtg tagaagcggg cgtcgcggta gcctggctgt
2248801 ccgcgggccg cgcgcagagc gtacaggtcg gcccacggtg tcccgcgagg caagaacccg
2248861 ataacaaggc cgccgccgtc ggcgagcaga cgccgcgttt cccggaatat ggcggccggg
2248921 tcggtgacga aacagagcgt gaatgccatg aggaccgccc cgaagtgccg gctgacgaaa
2248981 gggaccgcct cgccgacggc attggcgacc aggacgccgc gccggcgtgc gaacatcagc
2249041 gcatcacggg atggatcgag tccgaaccgc acgccgagca ggtcggcgaa acgtcctgta
2249101 ccgacaccga tttccaagcg tggctgggca aagacctcga tgagcggccg caacgcggcg
2249161 acctcggtcg ccaggatcgg ccgcccggtg ggtgagtcat accaggcgtc gtaggccgcc
2249221 gcgtcgcgcc cggcggccga cgatgccggc atccgggtgt caggcgtcac cgcgagctga
2249281 ttccagcaac aatcggcgtt cggcggccgc gaccgacccc ggggtagcag caatcgcgcc
2249341 cgaatggacc gacactgagg tgattcccat ccggaccaga tgctcggcga aagtcgggtt
2249401 gcccgagagc gcttgaccac acagcgacga tgtgctgctg acagtgatgg ttggcatcgg
2249461 ttttcctttc ggcgttctca gatcgcgctg cgccagatgt ggtaggcctg tcccacggag
2249521 cgctcacgcg gccccgccgt gtcgatccgg tgcccggtgt cccagtccgc ttgccgggcg
2249581 gccaaggccg ccgcgatctc ggcggtggcg tcggagttgc ccccggctct agcaacgatt
2249641 ctgtcggcca tcacgtcaac cgtcgccgaa cacctgaatt cgacaatcgc cgagtgcgtg
2249701 tccgccgcga gacgccgggc gcaggcgcgc atctgcggat caccccaggt accgtcgagg
2249761 atcactgagt gcccactacc caagagcagg cgggctttgc gcagcgcctc ctggtagacc
2249821 gccacaacgt tggcacgact gtagagcccg gagtccaaaa cgccgggctc cccggtgatt
2249881 actccgcaat cgcgtagccg ccggcgcaca tcgtcggttg agatcacctg cgcccccacc
2249941 agttcggcga ccccgcgggc cagggtcgac ttgccggtgc ccggattgcc accgaccagc
2250001 gccaaccgga ccgtagcgtg ctgtaggtgt tgggtggcga tgatcaggtg gcgcacggcg
2250061 tccgcagcgg cctccggttt gccctgggag aatcgcacgc actcgacttt cgcgcgcacc
2250121 accgcgcgat aagcaatgta gaagtcgcgc agcgacgccg gggcggtatc acccgaacgc
2250181 accgcatagc cggccaggaa gtagtcccca agatctttgc ggcccaagaa ctccagatcc
2250241 atggccaaaa aggcggcgtc gtcgatgcgg tcgaggtagc gaagctcgtc ttcgaactcc
2250301 aagcaatcca gcagcgccgg ttcgccatcc accaagaaga tgtcatcggc cagtagatcc
2250361 gcgtggccgt ctacaataca accttctttg atccggccgg cgaacaaaac ctcgcgcccg
2250421 gaaacgaatt cgtcgaccat gtgttcaatc cgccgaatca catccccgga gaccactttg
2250481 tccgcgtggt ggcgaagttc ggccaggttt tcgtgccaac gccgcgccac cgcaccgacc
2250541 tcgccttgag tatcgatgca ccggttacgc tgtgcgcgct ggtgaaaccg ggccaacacc
2250601 tcagcgatcg cgtccagggc accctcgacc ggcaggccgg cggtcaccat cgacgccagc
2250661 cgctgcttgt cgcggtaacg ccgcatgacg acgaccggtt cggcgtgccc gccgcttgga
2250721 tcgctgagat gggcaatgcc caagtagctc tgcgcggcca gccgactatt caactcgaat
2250781 tcccggatac aggcgcgctc acgctgttcc gccgtgcgga agtcgcagaa atccgtcacc
2250841 acaggctttt tcgccttgaa cgcccggtcg ccggccaaca caaccactgc ggtgtgggtt
2250901 tcgcgcacat cgatgaaagg ctcatctgtc acaggatggg cgtcacacgt gccgtcgttg
2250961 gtcggtgagt ccatggcggt agccaagcca agtagtcacg actgccgtgc cacgatcact
2251021 ggcacccgcg cggcgtgtaa gaccgcgtta ctgaccgacc ccagaagcat gccggtcaag
2251081 ccacctcggc catgactgcc aacgacgaca agctgggcgg acgccgactt ttgcaccagc
2251141 ttccgcgccg ggcgatcgca aacgacaacc cggctcaccg gcacatcggg atagcgttct
2251201 tgccaacctg ccaagcgttc ggcgagacta agctccgctt cctgctgtac agccgagaag
2251261 tccaaacccg gaagttccac cacttcgacg tcactccacg cgtgcacggc gatcagttcg
2251321 acgccgcggc gcgacgcctc gtcaaatgcc accgccgtcg caagctccga aaccggcgaa
2251381 ccgtcgattc ccaccagcac gggagcgtgc tgcggatcag ggatcaccgc atcatcgctg
2251441 tggatgaccg cgaccgggca cccggcgcgt cgcaccaggc tcgagctgac cgaaccgagc
2251501 aagcctcggg ccagcgctcc ccggcccgag ctgcccaaca ccaccatctc tgcctcgttg
2251561 gagatttcaa ccatggtagg taccggcgtg gaaaatacga gctcgctctt tacgctgagc
2251621 tttcgatccg ctccaaccgc ctctttggcg agcttgacgg cgttggcgac gatctggcga
2251681 ccctcgtcct cctgccaaac cccccaggtc tccggatacg gcatcggcgg ccacgtcgct
2251741 acatcggcgt tcaccacgtg gaccacggtc agcggaatgt tcctcatcgc cgcatcggtg
2251801 gcaccccaac aggcggcggc atccgattcg agcgaaccat ctaccccgac gacaactccg
2251861 tgctgcttgc ggggtttaga catctcattc tcccttcgcc tcgagcaacg ctatgaaccg
2251921 ggacagtcac cggtcatgag gctttagtcc ccaatcggac ggccaaccga ccatgattgg
2251981 attcgacgcc cgaatccaag cgtgcgctgt ggcatcgtcg tcaatgtgac cggaccgccg
2252041 cccaccatcg accggcgcta ccacgacgct gtcatcgtcg gcctcgacaa cgtggtcgac
2252101 aaggccacgc gagtgcacgc cgcggcatgg acgaagttct tggatgacta cctcacccga
2252161 cgaccccagc ggaccggcga agaccattgc cccctcaccc acgacgacta ccgccgcttc
2252221 ttggccggca aacccgacgg tgtagccgac ttcttggccg cccgcggaat caggctgccg
2252281 ccgggctccc cgactgatct caccgacgac accgtgtacg ggctgcaaaa cctcgagcgc
2252341 cagacattcc tgcaactgtt gaacaccggt gtccccgagg gcaagtcgat tgcctcgttc
2252401 gcacgtcggc tgcaggttgc cggtgtccgc gtggccgccc acacctccca ccgtaactac
2252461 gggcacacgc tggatgccac cggcctggca gaagtgtttg ccgtctttgt cgacggcgcc
2252521 gtcaccgccg agctcgggct accggccgag cctaacccgg ccggcctgat cgagacggcg
2252581 aagcggctgg gagcaaaccc cggtcgctgt gtggtcatcg acagctgcca gaccggtctg
2252641 cgcgccggcc ggaacggcgg attcgcgctg gtgattgccg tcgacgcgca cggcgatgcc
2252701 gagaacctgc tgtccagcgg agccgacgcc gtggtcgcag acctggccgc tgtcacggtg
2252761 ggaagcggcg acgccgccat ctccacgatt cccgacgccc tgcaggtcta cagccaattg
2252821 aaaagactac tgaccggccg acgaccagcg gtgtttctcg atttcgacgg cacgttatcc
2252881 gatatcgtcg agcgccccga agcggcaacg ctcgtcgacg gcgcagcaga agcgttgcga
2252941 gcgctggcgg cccagtgtcc ggtggcggtg ataagcggac gcgacctggc cgacgttcgc
2253001 aaccgggtca aagtcgacgg gctgtggctg gccggcagcc acggcttcga attagtggcg
2253061 ccagacggca gccatcacca aaacgccgcc gccactgcag ctatcgacgg attggccgag
2253121 gcggcagcgc aattggccga cgcactccgc gaaatcgccg gagcagtagt ggaacacaaa
2253181 cgcttcgcag tcgcagtgca ctatcgcaac gttgccgacg acagcgtcga caacctgatt
2253241 gcggcggtgc gccgactcgg acacgcagca gggctgcgtg tcaccaccgg ccgcaaagtc
2253301 gtcgagcttc gcccggatat agcctgggac aagggcaaag cactcgattg gatcggtgag
2253361 cggctcggcc cggccgaagt cggccccgac ctacggttgc cgatctacat cggcgacgac
2253421 cttaccgacg aagatgcctt tgatgccgtg cgtttcaccg gtgtcgggat tgtggtgcgc
2253481 cacaacgaac acggtgatcg acggtctgcc gctacctttc gtctcgaatg tccttacacc
2253541 gtttgccaat tcctctccca gctggcttgc gatctgcagg aggcagtgca gcacgacgat
2253601 ccgtggactc tggtcttcca cggctacgac cccggccagg agcggctgcg tgaagcgctg
2253661 tgcgcggtgg gcaacggcta cctgggttcg cggggctgcg cacccgaatc agcggaaagc
2253721 gaggcacatt acccgggcac ctatgtggcc ggggtgtaca accagctcac tgaccacatc
2253781 gaagggtgca ccgttgacaa cgaaagcctg gtcaacctcc ccaactggtt gtcgctgacc
2253841 ttccgtatcg acggcggagc atggttcaac gtcgatacgg tcgagttgtt gtcctaccgg
2253901 cagacgttcg acctacgccg tgccacgttg acccgcagct tgcgattccg agacgccggc
2253961 ggacgagtga ccacgatgac ccaggagcgg ttcgcgtcca tgaaccggcc caacctggtc
2254021 gcactgcaaa ctcggattga atccgaaaat tggtcgggca cagttgattt ccggtcacta
2254081 gtcgacggag gtgtgcataa caccctggtg gaccgctatc ggcaactatc cagccaacac
2254141 cttaccaccg ccgagataga agtcctggcg gactcggtgt tgttgcgcac ccagacgtcg
2254201 caatcgggta tcgcgatcgc ggtcgccgct cgcagtaccc tgtggcgcga tggccaacgg
2254261 gtcgacgcgc aatatcgggt cgccagggac accaaccgcg gcggccatga catccaggtc
2254321 accctgtcag cggggcaatc ggtcacgctg gaaaaggtcg cgacgatctt cacgagccgg
2254381 gacgccgcga cattgacagc ggcaataagc gcacagcgct gtctaggtga ggccggtcgc
2254441 tatgccgagc tctgtcaaca gcacgtccgc gcgtgggcac ggctgtggga acgatgcgcc
2254501 atcgatttga ccggcaacac cgaggaattg cggctcgtgc gactgcacct actgcacctg
2254561 ctacagacca tttcgccgca taccgctgag ctcgacgccg gggtcccagc gcgcgggctg
2254621 aacggagagg cctaccgcgg gcatgtcttc tgggatgcgc tgttcgtcgc tccggtgctc
2254681 agcctgcgga tgccgaaggt ggcgcgatcg ctgctggact atcggtaccg acgactaccc
2254741 gcggcccgcc gagcggcgca ccgggcgggc caccttggcg cgatgtatcc ctggcagtcg
2254801 ggcagcgacg gaagcgaagt gagtcagcag ctgcacctca atccacggtc cgggcggtgg
2254861 actcccgatc ccagtgatcg tgcccatcac gtcggtctag cggttgccta caacgcgtgg
2254921 cactactacc aagtgaccgg tgaccgccag tatctcgtcg actgcggggc agagctgctg
2254981 gttgagatcg cacgcttctg ggtaggcctg gccaagttgg atgacagtcg cggccgctac
2255041 ctgatccggg gagtaatcgg tcccgacgaa ttccattcgg ggtatcccgg caacgagtac
2255101 gacggaatag acaacaatgc gtacaccaac gtgatggcgg tatgggtgat cctgcgggca
2255161 atggaggcgc tggacctgct accgctgacc gatcgccgcc atctgatcga aaagctcggg
2255221 ctgacaacgc aggagcgcga ccaatgggac gacgtgagcc gacgcatgtt cgttccattc
2255281 cacgacggcg tgatcagcca gttcgagggc tattcggaac tggcggaact ggattgggat
2255341 cactatcggc accgatacgg aaacatccaa cgactcgacc ggatcctgga agccgagggc
2255401 gacagcgtga acaactacca ggcgtccaag caagccgacg cgctgatgct gctctacctg
2255461 ctgtcttccg acgagctgat cggcctgttg gcccggcttg gctaccgctt cgcgcccaca
2255521 caaatcccag gcaccgtgga ttactatctt gcccgcacct cggatggatc taccctgagc
2255581 gctgtcgtgc atgcgtgggt tctcgcccgc gccaaccgga gcaatgccat ggagtacttc
2255641 cgtcaggtcc tgcgctccga tatcgccgac gtccagggcg gcacaaccca ggaaggaatt
2255701 cacctggcgg ccatggctgg cagcatcgac ctgctgcagc gttgctattc cggattggaa
2255761 ctgcgcgacg accggctggt gttgagcccg caatggccgg aagcacttgg accacttgag
2255821 tttccgtttg tgtaccgccg ccaccagctg agcctgcgaa tcagtggccg aagcgccaca
2255881 ttgaccgcag aaagtggaga cgccgagcca attgaggtcg aatgccgtgg ccacgtgcag
2255941 cggctacggt gcgggcacac catcgaagtc ggttgcagca ggtgaccaat gtcgcacatg
2256001 gtgggtcgac gatctctcct ggaaaggacg gccggccgcg gtctccctta ttgcgttggg
2256061 tgttgtgtgc tcgtcgcctg cgactaaggg cactccaccg ggatagccgc gaccagaggc
2256121 gtgtcgactc cgatcgggcc caccgctgcg gcaccacccg gcgaacccag cggagccact
2256181 cggcccggca ggacttggtg gaaaaaggcg gcgttgtccc ccagatgctg gtgttgatcg
2256241 tcgggtagat cgccttccca gtagatcgcc tcgacgcggc aggccggttt gcacgcacca
2256301 caatccacgc actcgtcggg gttgatgtag agcattcggg cgccctcata gatacagtcg
2256361 accggacact cctgcacaca ggacttgtcc atcacatcca cgcactcact accgatcaca
2256421 taggtcacaa acggcaagct accggcccga tgccgaggat cgcgcctatc caaagacccc
2256481 taccggaaag gaccaaaggc cttattcgtc aagttcgtca ctggcacgtc gacgcggggt
2256541 gcaagaaaac cggggcggtt cacccgaccg ccagcgggat tcacgctccc ccaggccata
2256601 aacttacgat agcccgtcat ttcaagagcg cgagaagttc atcgacactc ccggtggtca
2256661 agatctgatc cgcgggaacc gcaacgaccg tgtcgctcaa gggaaagcgg tgttcgccag
2256721 ggtagacgat tgccaacctc gccagttgga ggtcgacaag agccgagcgc atcgaccggg
2256781 aaatcgacgg tgtagacgtc cgcttgatct cgaatccata gggacggcca gataattcga
2256841 catagagatc gagttcggcg tcttgctggg tgcgccagta atacagcgga ttcggggcga
2256901 gcagggccgc aagctgctcg agcacgaacc cctcccagct cgcgccgagc ttcggattgc
2256961 gttcgagggc aagccgatcg tcgataccga gcaacctgtg caacaaaccg gtgtcccgga
2257021 tgtagatctt gggtgatcgg cgttgtcgct ttccgatgtt ggcgaaccag ggcgtcagct
2257081 gacggacgac gagtgcatcg gtgagcgcat cgaggtatcg ccgcgccgtc gtctgagcaa
2257141 cgtcgagtga gcgggcaagt tctgcgccgc tgaagagctg gccatggtag tgggcgagca
2257201 tcgtccacgc gcgccgcatc gtcgcggccg gaatgcgcac accaagctgg gcgagatcgc
2257261 gctccagaaa cgtggtgatg tagccgtcgc gccacgccgc ggagtcctcg ttggagcgtg
2257321 ccgtgaacga gggcggtaga cccccacgca accagaggcg atcggcggcc gaggatccga
2257381 cgtcgcggac cgtcaggccg gacaactcca ccaactcgac gcgtccggcc aaactttcgg
2257441 acgccagccc gacaagatcg ggtgaggcgc tacccaggat aagaaaccgg gccggcatga
2257501 caggcctgtc gacgagcacg cgtaggaccg gaaacagatc cggaatccgt tgcgcctcgt
2257561 cgatcgtgat caacccgcta aggccggata aagccaacat cgggtcggca agccgtgtcg
2257621 cgtcgacggg attttcggcg tcaaacgtac attcgggtgc ggacttgccc accagccggc
2257681 taagggtggt cttgccggct tgacgaggtc cggtaagcaa caccaccggc gctcggtgta
2257741 gcgcgcgtcg caaccgcgcg gcggcgtcgc ggcgttcgat caacatgcat gaaattctag
2257801 cggtaggcgc tgatatttca tggttagccg cccccgggag actcggtggt gggtcccaca
2257861 cgcctagaaa gtcgccggcg ataacgaccg gccaggtcag cggggttggc cgcagcccga
2257921 taaggctctc gatctcgtcc atcaggcatg ctccacatcg cctgcaccag ggcaaagctg
2257981 caccggtcgt gcgagccggt tagcaaatag cacgttcata cacataaatg tgtatagtgg
2258041 tgttgtgtca cggaccaaca tcgagatcga cgacgaactc gtggccgccg cacagcggat
2258101 gtaccgactc gattccaagc gaagtgccgt cgacctcgcg ctgcgccggc tcgtgggtga
2258161 accgttgggc cgcgatgagg ctttggcgct gcagggcagc ggtttcgact tcagcaacga
2258221 tgagatcgaa tcgttctcgg atacggaccg caagctcgcc gacgagtcgt agatgatcgt
2258281 cgacacctcg gtctggatcg catatctctc cacgtcagag tcgttggcca gtcgctggct
2258341 agccgatcgc attgccgctg actcgacggt gatcgtgccc gaggtggtga tgatggagct
2258401 gctgatcggt aagaccgatg aggacaccgc cgcactgcgc cgacggctcc tgcagcgatt
2258461 cgctatcgaa ccgctggccc cggtccgcga cgcggaagat gccgccgcca ttcaccggcg
2258521 ctgtcgtcgc ggcggcgaca ccgtacgcag cctgatcgat tgccaggtgg ccgcgatggc
2258581 gttgcggatc ggggtcgccg tggcgcatcg tgatcgcgac tacgaggcga tccgcacaca
2258641 ttgcggacta cgcaccgagc cgttgttctg actgcggaca cccggacgat ttcgtgtctc
2258701 acatctgacc cgtggccgtc gtcgtccgcc gccgggtaca tcgacatagt ggaccaggga
2258761 acatcgccag cgcatgagtg agcgcggata ccacccggtc cggggacgcg ttggcgctgg
2258821 ccgaagccga ccggcccagc gatgacatcg acttcaagga cgttcggctt tcagcgcgac
2258881 gatcatccgc ctcaggctgt cgcgggtcgc ttgcagcgcg gccgggtcta cggcgtcagc
2258941 aagtcggttg ttgacgacga tggcgcgttc ggtgattgcc tggagaacgc ggcgaccatt
2259001 ctcggttagc accagcagtg gtgatgtgcg gtggtcgggg ttgtgtctga gctcggccaa
2259061 gccgcaaacg accagatcgt tggccactcg ctgcaccccc tgacgggtaa caccaaggcg
2259121 gcgagcggct tggggcacgg tcagcgctcg atcggagacc acgctcagca gctgccatcg
2259181 cgcctgcgtg tgcccctctc tggcagcgac cacctcacct gagcgccgta gcaggccagc
2259241 gagctcgaat acgtctgcta ccagccgagc gatctcatcg gacatcccgc ctccaacttt
2259301 gacaatatat tgtcatcatg gttcgatgct gtcaaaatcg aaacggtcct gtcgtcgtcg
2259361 tgaaaccctt cgcatcggag aaaagatgag cgctccaatt acgaatcttc aagccgcaca
2259421 gcgtgatgcc atcatgaacc gaccagcggt caacggcttc ccccatctgg ccgagacgct
2259481 gcgccgcgcc ggtgtccgaa ccaatacctg gtggctaccg gcgatgcaaa gcctgtacga
2259541 gactgattac ggtccagtcc ttgaccaagg cgtgcccctg atcgacggcg tggccgaggt
2259601 cccggcattc gaccgcacgg ccctcgtcac tgcgctgcgc gccgatcagg cgggtcagac
2259661 gtctttccga gagttcgccg cggcagcctg gcgagccggt gtgctccgct acgtcgtgga
2259721 cctcgagaac cgcacctgca cctacttcgg cctgcatgat cagacgtata tggagcacta
2259781 cgcggcagtg gagccttccg gtggtgcccc tacgagttga gctgcgcccg tcgcagcgac
2259841 attccagcag accgcgacgt cagtcttggg cggcctgact atcgcgatga tccgtcgccc
2259901 gctcatcaac ccggttcgtg gtcaagactt ttcaccgggg cgacgtttcc tggggctagt
2259961 aaggcggttg ccgatcttcg tgaagcggcg gtgtccgaga cccacgacac caaggacgtg
2260021 ttagccgctt tggccgcgcg caagtccccg gtgcgacctt tctgatgcga tcgacgatgt
2260081 aggtgggatc tcgtgctctc cgcaccagtc gttgggatcc tgggcgattc cggacgcttt
2260141 gtcggtggtg acgcggtcga tgatccagcc tagcgccgaa cccgagccga gcaggcaacg
2260201 cccggcccca agtggtgcgc accgccgccg tggatcttga tgggagcacg cgaagctcac
2260261 tggtgcacca tccttgtgtc ggtgaccttg gatggattgc cgatgcaccc aaggcgccgc
2260321 tgggttatcg ccctgctcgc tcgacagccg tgatgtccac gatgagttct gcggagtccg
2260381 gcggtagccc cggacgcgcc gaccgtcgac aggactgagc gccgacgagc gccgaacagt
2260441 gagcggccca aaccactacc ctgcccgacg agccgcggaa cggcgtcacg ggtggaatcg
2260501 attgggcgcg agatgatcac gcggcgtcga tcgtcgatgc gcgtgggcgc gaggttcgcc
2260561 gcgccacgat cgagcacaac gccgccggac tgcgcgagct gctcgagctg ctgagccggg
2260621 ccggtgcccg cgaggtcgcc atcgaacgcc cggacggccc ggtcgtggat accctgctcg
2260681 aggccgggat cacggtggtg gtgatcagcc ccaaccagct gaagaatctg cgcggtcgtt
2260741 acggctcggc tggcaacaag gacgaccggt tcgacgcgtt cgtgctcgcc gacacgttgc
2260801 gcaccgaccg gtcccggctg cgccccctgc tgcccgacac cccggccacg gccaccctgc
2260861 gccggacctg ccgcccccgc aaagacctcg tcgcccaccg ggttgcgttg gccaatcagc
2260921 tgcgcgcgca cctgcgcgtc gtctttccgg gtgtggtcgg gttgttcgct gaccttgact
2260981 cgccgatcag cctcgcgttt ttgacgtttt tgccccgttt cgactgccag gaccgcgcgg
2261041 actggctgtc ggtcaagcgc ctggccggct ggctggccgc cgctggctac tgcggccgtg
2261101 ctccacgacc ggctcaccgg tgccccgcgc ggcgccaccg gtgacgaggg tgccgccaac
2261161 gcccacatca cccgggccat ggtcgccgcg ctcaccagcg tcgcgaccca gatcaagacg
2261221 ctcgacgcgc agatcgccga acagctctcc ttgcacgccg acgcgcatat cttcacctcc
2261281 ctgccccgct ccggcaccgt ccgcgccgcc cggctgctcg ccgagatcgg ggactgccga
2261341 gcccgtttcc ccacgcccga atcgttggcc tgcctggctg gcgtcgcccc ctccacccgt
2261401 cagtccggca aagtcaaaca cgtcggattc cgttgggccg cagacaaaca actccgcgac
2261461 gccgtctgcg acttcgccgg tgacagccgc cgagccaacc tctgggccgc cgaccgctac
2261521 aaccgcgcca tcgcccgagg acacgaccac ccccacgccg tgcgcatcct ggcccgcgcc
2261581 tggctctacg ccatctggca ctgctggcaa gacggcgccg cctaccaccc tgccaaccat
2261641 cgcgccctcc aggcactgct caaccaagat caagaccggg cggcttgaca cagggctact
2261701 catcggccta gcgggtgggc gccaccagcg ggtagcacga acgaaatcct tgatgcccca
2261761 aaccgtttaa gcgttactgc agggtacagg taccgagcgg gacccgctgc cgggcctagt
2261821 tgcttatcgg tggtggttgc ggctggaagg gttcatacca ccaccagtcg gcgcgctcgc
2261881 cggtgggccc aggccacggc gctaccgccg gcggcggctt cgtcgacgcc cgcgccaacg
2261941 atcccgcgct caaaggtcgg cccgcgctgt cggcgacggt gaggttgtct gccggtccgg
2262001 taatggtgat caggccccga tggtgtgccc ggtggtgata cgggcacacc agcaccaggt
2262061 tggccagctc ggtggcccca ccgtcctgcc aatgtcggat gtggtgggcg tgcaaacccc
2262121 gggtggcccc acaaccggga accacacacg tgcggtcgcg atgctcaagc gcacgacgca
2262181 accgacgatt gatctgacga gtcgttcgac cgcagccaat gacctgcccg tcacgttcaa
2262241 accaggcctc aaaggtggca tcacagagca gatatcggcg ttcggactcg ctgagcagcg
2262301 gacccaggtg caggccagcg gcacgctcct gcacgtctag atgcatcacc acggtggtgt
2262361 gctgcccatg tggccgacga gccacctcgg cgtcccagcc ggcctcaacc agacgcagaa
2262421 acgcctcaac attgcccggc aacgggggcc gctgatccga cacaccgtcg ctgttgtcgt
2262481 gatcacgctt gtactcggcg atcaacgcat ccagatgaga ctgcaacgcc gcatcgaact
2262541 tcgccgcctc cacgtgcgga agcttgattc gccaacaact gaactgctca tcggcgctcc
2262601 tggtgatcga gggccgcggt tccggccgaa aatccggttc gggttcgggt cgcggttcca
2262661 acttgagcgc ggtccgcagc tgattcaccg tggcaacgcc ggccaactgc gcataatgcg
2262721 catccgaacc ctcacccgcc cgccccgcga tcaccccaac ctgatccaac gacaaccgcc
2262781 cctcccgcat accccgggcg cagcgcggaa actccggcaa ccgccgcgcc accgtggcga
2262841 tcgtgtgggc gttgcctgac gagcagccca tcttccaggc caccaacccc gccaccgacc
2262901 gcgcccccgt cacaccccac aacccgtcgc gatccagctc agccacgatc tccacaatgc
2262961 gcccatcaat cgcattgcgc tgaccggcca actccgccaa ctcctcaaac aacacctcca
2263021 cacgctcggc aggactgact accgctgcgc cagacgtcgc ggtcgaggac atgagttcat
2263081 catcgcagca gggtctgaca actccggcca acccgaatcc acgcccgggg ccgtgccgtc
2263141 atcaccccgc aaagagatgc tcggctccgg ctccgccccc gccggggcca agggcacacg
2263201 agacaacgaa atcagcgaac ccaccatgga aacgctcaac ggcgtgggcc gcgaagccgg
2263261 cgaaatgctg ggagcagctg gtggacatcg catagatagg ccccagaccc agccagcacg
2263321 gctccaaccg tcgacgcgcc tagctgcaaa atcgcatgct tgtcagcgga taccggtata
2263381 ttttccggta tgttttcaga gccttatccg accgatggcg aagtcatgac ggaactcggc
2263441 gacaagttcc ttgctgctct tgttggcacc atcagggata cgcgcttcga catcgccgac
2263501 atgcggaact ggcggccggg atggtttccg accatgcata gccggtgtct gtccaacctc
2263561 atccacgaca gaatctgggc acacctggtc accctcatcg cgagcaatcc aggcaccagc
2263621 atcaaggaca agggtgccac ccgcgagatt gtggttggcg cacacctgcg gttgcgaatc
2263681 aaacgccacc acgcaggtga cgagatcagc acctacccga cccgaaccgc catcgaattc
2263741 tggcaacagg gcagccagcc cgccttcccg gggctggaag aggttcgcat tgcggtgggc
2263801 tatcggtggg accctgatac ccgcgagatc ggagcccccc tgctgtcgct tcgcgacggg
2263861 aaagatcacg tcatctgggt agtcgaactc gacgagcctg cggccggcgt gaagatcacc
2263921 tggaccccga tcgagccgac actaccgtcc atcgacttcg gtgacttggg tgaagactct
2263981 ggagcatcgg gggaacgatg aacggcctgg gagacgtgct cgcggtcgcc cggaaggctc
2264041 gtggactcac ccagatcgaa ttggccgagc tggtgggact cacccagccg gcgatcaacc
2264101 ggtacgaatc aggcgaccgt gaccccgacc aacacatcgt ggccaagctg gccgaaatcc
2264161 tcggtgtgac cgacgatctg ctcatacacg ggaacaggtt tcgaggtgcg ctcgcagtcg
2264221 atgcgcatat gcgccgccac aagaccacga aggcgtcggc ctggcgtcag ctggaggccc
2264281 ggttgaacct gttgcgcgtg cacgcgtcat tcctcttcga ggaagtggct atcaatagcg
2264341 agcaacatgt gcccgcgttc gacccggagt tcaccgccgc cgaggacgcc gcccggttag
2264401 tccgtgccca gtggcgcatg ccgatgggcc cggtcgtcaa cctgacccgg tggatggagg
2264461 ccgcgggctg cctggtgttc gaagaggact tcgccaccca gcgcatcgac gggttgtcgc
2264521 agtgggtcga cgactacccc gtcatgctga tcaacgccaa cgcagcaccc gaccgaaaac
2264581 gcttgaccct tgcccacgaa ctcggccacc tcgtgctgca ttccaccaac cccacggaga
2264641 acatggagac cgaagccacc gccttcgccg ccgagtttct catgcccgag agcgagattc
2264701 ggcccgagct gcgtcggctc gatctcggca agttgctcga actgaaacgg gaatggggcg
2264761 tctcgatgca agccctcctg gcgcgggcat atcgcatggg cctggtatcg gccgaggctc
2264821 gcaccaagct ctacaaggcg atgaacgcgc gcggctggaa aaccaaagag ccaggcatcg
2264881 agtccatcgt gcgagaaaaa ccgagcctac ccgcccacat cggcatgaca ctccgaagcc
2264941 gcggattcac cgaccagcaa gccgccgcca tcgccggata cgccaatcct gcggacaatc
2265001 cattccgccc cgaaggtggc cgcctccatg cgatttgact tccgattgac gctgggtttt
2265061 catgccgacg gcgccaggtg cggtcacaca aggcggccgg aacaggcatc gattcttggc
2265121 gacgccgttg ctgtaccgat agcgactgcc ccgtatcgat cccagggaac gtgaccatgg
2265181 tcgtagggat gacttgacag tttcaacggg gtgcgaccac cgttgcgctc agaaggcata
2265241 cgttggtgga acacgtcgga aagctgggag gtgaatctga tggctggcga ccaagagctg
2265301 gaactgcggt tcgacgttcc tctttacacg cttgccgagg catcgcggta cctggtggtt
2265361 ccccgcgcca ccctggctac gtgggctgac ggctacgagc gtcggccggc caacgcaccg
2265421 gcggtccagg ggcaaccgat catcacggct cttccccacc cgaccggcag tcacgctcgg
2265481 ctcccattcg tcggaatcgc cgaggcgtat gtgttgaacg ccttccgccg agcgggcgtc
2265541 cctatgcagc ggatccggcc atccctcgac tggctaatca agaatgtcgg gccacacgcg
2265601 cttgcgtccc aggatttgtg cacggacggt gccgaggtgc tctggcggtt cgctgaacgg
2265661 tccggggagg gcagtcctga tgatctggtg gtcagggggc tgattgtccc gcgatccggg
2265721 cagtacgtct tcaaggagat cgtcgagcac tacctgcaac aaatcagctt tgccgacgac
2265781 aacctggctt cgatgattag gttgccgcag tacggcgatg ccaacgtcgt cctcgatcca
2265841 cgccgcggct atgggcaacc ggtgttcgac ggaagcggcg tccgggtagc tgacgtgctc
2265901 ggcccattgc gcgccggcgc gacgttccag gctgtcgccg acgactacgg tgtgaccccg
2265961 gaccagcttc gagacgcgct cgacgccatt gcagcctgat cggaatctcc tcgccgacct
2266021 cgatcacatc tttgtcgacc ggagtttggg cgctgtgcaa gtcccgcaac tccttcggga
2266081 tgccggattc cggctgacaa cgatgcggga gcactacggc gagacgcagg ctcagagtgt
2266141 cagcgaccac aagtggatcg caatgaccgc cgagtgcggc tggattggat ttcacaagga
2266201 tgccaatatc cggcgcaacg ccgtcgagcg acggacggtg ctcgacacgg gagcccggct
2266261 attctgtgtg ccgcgggccg acatcctggc agagcaagtc gcggcacggt atattgcgtc
2266321 ccttgcggcg attgcccgtg ccgcacgatt tccgggacca ttcatctaca cggttcaccc
2266381 gagcaagatc gttcgcgtgc tctagtcgtt catcgctccg ttaaccgccg gcgaggccgt
2266441 cgacgatctt catggtctcg acgctgacgg tggtcacctt cttgatgagg tcgacgatgt
2266501 aggtgggatc gtcgtgttcg tcgcaccagt cgttggggtc gttgacgatg cccgacgctt
2266561 tgtcggtggt gacgcggtag cgctcgatga tccagccgag cgccgagcgg gagcgagcag
2266621 gtagcgctcg gcctcgtcgg gaatgccggc gatggtgacg cgggagtaga acgatcgcca
2266681 agtggtcggt cttggctgcc cacttcatcc ccggcgccac cggcaggtct cgcggtcatc
2266741 tcgaccaacg gagggccgtc ggtggttcgt atccggccaa gaacggcgag aacggtttgt
2266801 gcctctatgc cagggtgaat gtctcatctc ccaggcggac ggtgatatcc agttctccgc
2266861 caagagcgga cacgtatttg cgcagtgtgt tgacctgtgc ggagccgatg tcgccgttct
2266921 cgatgctgga tacccggctc tgccggatgt gcgccagcgc agccacctgg acctgggtga
2266981 gtgactgagc cgcgcgcagc tcccggagcc ggaatgcccg cacttcatcg cgcattcgtg
2267041 ccttgtgccg gtccaccgcc tcccggttaa cgggacgtac ggcgtccatg tcccgtagtg
2267101 tcatcgccat cgtgccactt accctttctt gcgcttgcgc ctctttggct tcgtgtcctc
2267161 gaactgtgcg agatgttcgg caaacatctc atcggccgct ttgatcttct cgtcgtacca
2267221 ctgggtccac cgcccggcct tgttaccggc ggccagcatg atcgcctgcc gcgccgggtc
2267281 gaaggcgaac agaatgcgga cctcggaccg cccttgtgat cctggacgca gctccttcat
2267341 gttcttgtgg cgcgacccac gcaccgtgtc caccagagga cagccaagtg cggggccctc
2267401 ttcctcgaga acctcgatag ctgcgaacac caattcgtag gtctctcggt ccaagccgtt
2267461 gagccaggcg gagatgcgct ccacatccgc cgtccacccc acagagtcgc agagtagcgc
2267521 gatacgcgat atcacacaag ggtgatattc ctccgggtaa gagcagcggg cgacggggct
2267581 accgtcgagg aaatgccggc aggcgaggac ggactctgcg cacccgggcc gttgaaacag
2267641 tagcctgtgc caggccgaga attcatcccc acgtatgagg cagtacagtg cgccgccgtg
2267701 cgcgttctcc catggaacgt tcacgggctc ccgtggatga caggcgtttc atgaacgcca
2267761 gcgccgccgc aacccgaccg aaagcggttg accccaagga gagctggaag tcgaggccac
2267821 caccttcgcc gcggagttgc tcatgcccga gagcgagact cgtcccgaaa tacgccggct
2267881 cgatttcggc aagttgctcg aactgaagcg ggaatgggcg tcgacccgct cgaccagccc
2267941 cagccgggtg accagcccca gccgggtgac cagccgatgc accgcggcga tcccaccgaa
2268001 gccggtggca tcgatgttgg cgccgacctc gtagcgcacc gcgcccgaac ccagcatcgg
2268061 cctgggctgc gccgcccagc gtccagcccg cgcgtgccgc gccgccaccc tgcgccctcg
2268121 gcgtgtgatg tttcgccgac tctgttcatg ggttatcttc ttcaccacaa aggcctttcc
2268181 tgctgggctg tgttgaggtc gcaaacccag ccagggtaag gcctttggcc tctcctaccc
2268241 ggccgacacg cttactgaag gcctagtcta ggcaggccat tcaatctgcg gaatcgaaaa
2268301 attcggttcc agcctgctcg tttcctttcc gacagcgatc tgacgttgcg taacgtcatt
2268361 tgtacggact cttttagcgg cattgatttc agatgccaac gccgtctgtg ctgtagcgcc
2268421 gattggccga aactgtaaat ttgtatgatt atttaaatct ttgacgaaca cgcgccacaa
2268481 acgtactatc tctttggcaa agtccaccgg catctcattc aacggttttg tttgcgcgtg
2268541 gtcgtcatat gttggtaact gtgtaaccgg ccgcctatct tgcgcgtgca tcatatgact
2268601 atgaatcggc cttctccagt gaaattgata caagatcgat ccgataagcg gtaccttgta
2268661 cacagtgcaa ttgtagtaat tcgcgttttg tcctacgctt gtattctgcg tgaagaattc
2268721 aaacacgcca ggcccgggcc gtcgtcaacc aattcgcggt atgcctcaac cactttcggg
2268781 aacagctcgg caacctgctt ggacgtcttg atgtccttgg cgaacgccac cgcccgacgc
2268841 atcggcggct caccggcgac aatgccggta ccggaccgct tggccaggcc attccagcag
2268901 ccgacgatct tggaggcgtc gtcgagcatc agctcgccgg aaaccccgga gagttcctgc
2268961 tgcaaccggg gcgcgatcac gccctgatcg acggtgagca ccatcacctt gtagtcggtg
2269021 agcagcccgc gctccaccgc ctcgccgaac gacagccggt gaaactccgg cccgaacgtc
2269081 agctcgtcgt ccatcgacac caactcggcg gagtgctggt cggccctgtc cttgatgctc
2269141 tcggtgaaaa tccttggcgt ggcggtcata tacagccgcc gggccgcctt cagatactga
2269201 ccgtcgtgca cccgcacgaa gttcgactca tcgtcccccg ccagcgtcac gccggtggtg
2269261 cggtgggcct cgtcgcacat caccaagtcg aactcgtcga cccccagccg ttgggccttg
2269321 gccaccgtgg gcagcgactg gtaggtgcaa aacaccacgg tcaggccctg ggcgcgcctg
2269381 cggtgcgcca tttcgtgcag caatacccgc gcgtcggtgg tgaccgggat cggcacatcg
2269441 tggacgtggt agtcctcggc cgagcgcgac accttggtgt ccgagcacac cgcgaacgcc
2269501 cgcacatcca gctcactctg tgcggtccac tcccgcagcg tctggctcaa cagcgaaatc
2269561 gagggcacca gcaacagaat ccgcgcgctg ccgccgttgt cggcggcgat gcgctcggcg
2269621 atcttgagcg cggtgaacgt cttgccggtg ccgcaggcca tgatcagctt gccgcgatcg
2269681 ttgcccaccg cgaacccgcg gaacaccgcg tcgatcgcct gctgctggtg cggccgcagc
2269741 tcgtggcgtt tggccggggt caggttcacc tgcaggtcgt cggccggcca ggcgatgtcc
2269801 cagtcgatcg gcgattcggc gatctcggcc atgccgatgc gctgcaccgg gaccaactga
2269861 tcggccagcg cgtcctcggc attgcggccc caccgatccg tcgtggagat gatcacccgg
2269921 ttggtgaagc ccgtcttgcc cgacgcggtg aaaaacgagt cgatgtcccc cttggccagt
2269981 gtgtgcgtcg gctcgtagaa cttgcactgg atcgcggtgt agttgccggt gtcacgttcg
2270041 cgggcgacca ggtcgattcc ggtgtcggtc ctgccccgcc gctccggcca gtcgatccac
2270101 caccacaccg cgtcgtactg ctgggccatc gtcgggtcca gctcgaaata gcgcaccatc
2270161 aactgctcga acttggtccc gcgctccgcg ttcgacggag ccttccggaa cgcctcgatg
2270221 acgtcgtgca ccgaccccat agttcaatga ccatactggc ggcaaccgac acgtggcggg
2270281 atccctcgcg ttcgatccaa cccaaccagc tcggccaacc gcatcgcggg ccggcatctt
2270341 cgccgtccta actcgggaaa tagcggttgt cactatctga gcgcagctat ctcatttgcg
2270401 gagaactagc cctgatcaat tcctgcctcg gttacgtgtg tcatgatcag ccggccagtt
2270461 cgaggttgag gtgaccttca catagtgaag cctcccgggt ttcgtgcgca ccttctttcg
2270521 agggaaggac gccacgctga gctgcgagtt cgtcgccgag catcgagccc ggttcgaggt
2270581 cgctgcgatc tgtcgcgtgc tgtgtgggca gggctgcaga tcacccggag aaccttctac
2270641 gcctgggcag cgtcggccgc cgtctaggcg tgccctgcgg gagatgacgg tcaccgagcc
2270701 cctggccggt tacgacgggc ccgataccga tggccgccgt aagcccgagt cactctacgg
2270761 tgcggccacg atctgggatc gacgagccat gttcagccgg ataggcgtgg atgagggcgg
2270821 tggtcagctt gggaacggtg tgggtgagtt cgtgttcggc gtcgtgggcg atgcggtgag
2270881 cttgcgcgag gtccagggcg gggtcgacgt cgagttcggc atcggcgtgc aagcggtgtc
2270941 cgatccagcg catccgcacg ctgcgtaccg cctgcacgcc gggccgggcc gccagggctt
2271001 gttcggcggc atcgaccatc gctgggtcga cgccgtcgag caggcggcgg aacacatctc
2271061 gcgcggcagt tcgtagcacg gccagaatcg ccgccgtgat gagcaggccg acgatggggt
2271121 cggccagtgg gaacccaagt gcgacaccgc cggccgagca cagcacggcc agcgaggtga
2271181 atccgtcggt tcgagcgtgt agtccgtcgg cgatcagggc ggccgagccg atgcggtgcc
2271241 caaccctgat gcggtagagg gcaacccact cgttgccgat gaatccgacc agcccggcca
2271301 gggcgaccca gccgacatgc tcgatctgct gcgggtggat caggcgggcg atggcttcgt
2271361 aaccggcgat gatggccgac atcgtgatca tcgcgaccac gaacgacccg gccaggtcct
2271421 cgacgcgacc gaatccgtag gtatatcggc gagtggcggg cttggcgccc aacgcgaacg
2271481 cgatccacaa cggcaccgcg gtcaacgcat cagcgaagtt gtggatggtg tcggcggcca
2271541 gcgcaaccga ccccgacatc accacgatca caatctggat gagcgcggtc aacccgagaa
2271601 ccaacaagct gatcttgacc gtacggatcc ctgccgcagt ggattccagg gtgtcgtcga
2271661 cgctgtcggc ggcgtcgtgg gagtgcggcg cgaagatctc cttgatcatc gccggcacac
2271721 ctcgtgaatg agcgtggtcg tgggtcatcg ggcgcaggcc ctttgtgaca gcaggccaga
2271781 tcggccgcgt tcgaccacca agcaagctct tttatctgca ttcatacgca gataatagcg
2271841 gatgctctcg ccggttccag tactagctgg gacggacgac gatcaccggg attctcaccg
2271901 aatgggctac cgcggaactc accgaaccca acagcatgcc ggaaaacccc ccgcgcccat
2271961 ggctgccgac caccaccagc tgagcttgct cagaatgctc gagcagccac cgagcgggct
2272021 tgtcgcacac cagcgatcgg tgcacgcgga catccggata ctgctcttgc cagccggcga
2272081 ggcgttcagc gaggacctca gcctctctct tctcgcgctc tcgccaatcc atccccagaa
2272141 ccggaaacat ccccagatcg gtccaggcgt gcaacgccac caggtccacc cttcggcggg
2272201 aggcttcgtc gaaggctagg gccgttgccg cctcagaggc tggcgatccg tcgatgccca
2272261 ccaacaccgg tgcatcggag tcgggagtcg cgccattacc ggaatgaatg atggccactg
2272321 gacaccgcgc atggtggagc aacgcggtgc tgatcgagcc gagcagcagt cgacccaatg
2272381 cgcccatccc ctggctgccg acgaccatca accaagcctg ttgggatgca tcgataagcg
2272441 tcggcacaac attggaaaag accaactcgg tatgcacctg cggcggtttg gactcaccca
2272501 agctgttggt gagcgcctcg cgggcctgct caatgacctg ctgtgcgttg tccttttgcc
2272561 actcagtcat attcgcgtac agctggccca ccggccagcc gacaaccaca ggggcaacaa
2272621 tgtgcagcag ggtgatgggc agctggcgca tgacggcctc acgggcggcc caggctaccg
2272681 ccgcgttgga ttgcgctgat ccgtcgacgc caacgagtat tccgtatttc gctgtcgcag
2272741 cagacatttc acgctccttg cggtcggaac acagtccatc aatccatcag cgcagcggtg
2272801 cagaccaccg cagcaaggtg cctccggtcg gcatgttctc gactgtgaat tcgccgcccg
2272861 cgtcgtcggc acgctggcgg agattgcgca ggccgctttc ggtgatgtcg ccggagatgc
2272921 cgacaccgtc gtcgacgacc tcgacccgca catcatcctc gacgctgacg ttgatggcca
2272981 ggctggtcgc gttcgcgtgc cggacagcgt tgctaaccgc ctcccgcaga accgcttcgg
2273041 cgtggttggc caggacggtg tcgacaacgg acagcgggcc cgtgtactgg accgtggtgt
2273101 gcagcgcggg gatcgcgagt tggtcgatga ccttgtccag tcggtggcgc agacccgtcg
2273161 cccgggaggg cccggcgtgt aggtcgaaga tcgcagatcg aatctcctga atgatttcct
2273221 ggagatcgtc gatgctgctg tagatggatt cccggacggc ggggacacgt gctcgcggag
2273281 cggcaccctg cagggtgagc ccgactgcga agagccgctg gatgacgtgg tcatgcagat
2273341 cacgtgcgat ccggtcgcga tcggtcagga tctccacttc tcgcatctgt cgctgcgcgg
2273401 tcgccagccg ccaggcgagc gcagcctggt cagcgaaggc ggccatcata tcgagctgtt
2273461 tgtcgctgaa cggctgttca tcggcactgc gaagtgcgac cagcacaccg gcaacagtgt
2273521 cggcggcacg cagcggcagc accagggcgg gcccgggctc caccgggccg tcgaccgcga
2273581 ggtcaagccg gtcgaaccgg cggggcgtac ggtcgtgaaa gactcccccg atcgacgttc
2273641 cgctgacggc aaccgtcatt tgcttgaccg ccggggagat ctctccggcc acctctacga
2273701 tgaccaggtc gtcgacctcg caagccggcg cttcgtcgtc gagcggcacc gccaccaagg
2273761 tggctgcccc agccatcaac gtcaacgctt cctcggcgat gagccgaaac accatggccg
2273821 ggtccgcacc ggccagcatc tgcgttccga tgtcgcgggt tgcctcgatc cacgcttccc
2273881 gggtccgtga ttcctcgaag agacgggcat tgtcaacggc aatcccggcc gcggcggcca
2273941 gcgcctgcac cagcacctcg tcgtcatcgc tgaacggctg gccatctgcc ttctcggtca
2274001 agtaaagatt gccgaacacc tcgtcgcgga tgcgcactgg aaccccgagg aaggtccgca
2274061 tcggcggatg gtgcagcgga aatccaaccg atgcgggatg ccgcgagata tcgtccagcc
2274121 ggatcggctt tggctcctcg atcagcgcgc cgagaacacc tcgcccctcc ggcaatgagc
2274181 cgatgaggtg ccgggtctct tcgtcgatcc cctcgtagac gaattcgacc aatctatggt
2274241 cgtaaccgcg caccccgagc gccccgtagc gggcatccac caactcggcg gcggtatgca
2274301 caatggcgcg cagggtggcg tcgagcttga gtcccgatgt gatcgccaag atggcgtcga
2274361 tcagaccatc cagccggtcg cggccttcga cgatctgttc aatccggtct tggacttcca
2274421 gcagcagctc tcgcaaccga agctgcgaca gtgtctcgcg caatggcggg ctgccagggt
2274481 taacgttcgc cctgtcaggg tgtgtcacat agctatgttg acaccggagc tgcgctcaac
2274541 caactggtct ggctacccag cggcacagtc acagatactg ctgaccgacg accagcaggg
2274601 tgcagccggc ctcctgcaac acggcgttgc ccggcgctcc cacaagttgc tccacatgct
2274661 cctggtcgct cgcgctgagc accaccatgt gtaccgatcg acccagccca gccagataat
2274721 ccagcagctc gccgtgcact gccgccgatt gcacccgcac atcgggatac cgtggttgcc
2274781 aacgggcaag ccagcggtcc aggctggcac ggacgtcgtc cccggtatcg cccactccgg
2274841 attgccggca ggtgaccacc cgaaccggcg agtcgcgcag ccgtgcttcg gccatcaccg
2274901 cccccagcaa aacaccgata tcggacgacc cgtccgcctc gacgacgatc catgcggcgt
2274961 cgcgtccgat ggggacccgg tggggtcgca cgatcgccac tgggcactgc gccgataacg
2275021 ccagggccgc tgcggtagat cccacccgct ccggtcggaa gtggtgcacg ccgatagcgc
2275081 caacgcacac cagggcagca gccgccgaag cgcggatcaa cgaggtgacc ggccgctcct
2275141 gggtgatctc cacctcgacc ttgaccggcc ggtccgccgc ctcgaccgct gtgaacgcgt
2275201 agcgcaccgc gttctcggcg gcggcgagtt tgcgagccgc cgcgccgtgt gcggcgtacc
2275261 cgggatcgtc gggttcgatc gcgtacagca gacgcagcgg gatgtcacgg ctggctgcct
2275321 cgtcgaccgc ccacagtgcg gcttgcacgg ccggcttcga gccatcaata ccgacgacga
2275381 tcgatggggg tttgtgtgat tggttcatgg cgaggcttcc gggttaacga tcgggtgcca
2275441 aacgtattga tcctgcccga cttcggtggg ttcggccgcc agctcgaaga acctctccac
2275501 atcgtcgcga ttgcaggccg cggtgcctgg cgtcagcagc atggctgcac ctgccgcgtt
2275561 tcccaagcga acggacttga tgagcgacca gccacggctg aggcccacgg taatcgcggc
2275621 caccatcgcg tcgccggcgc cgacaccgct aaccgcggtc atcggaatcg acgaaaatcg
2275681 atggctcgca tgtcgtgtgg ccaatagcgc gccctgagat ccaagcgaga ccaccacgac
2275741 ctcggcgcgc ccacggtcaa tgagttcgtg tgcggcggcc agttgttcgg gctcggtcag
2275801 cagttcggat ccgacgcact cgcgcagttc ccgcacgctc gccttgagaa gaaacacccc
2275861 ggacgaaatg tgctgcaacc cgccaccaga tgtatccagg atcagcggag tgctcgatcg
2275921 gcggcagatg tcggcaaccc gctgatagta gtcggcagcc acacctggcg gcaggctgcc
2275981 actggccacc acaaaggcgg ccgaagccgc cgcaccgcgc agttcgtcga ggcattgctc
2276041 ctgctccgcg acggtcagcg acggccccgg aagcacgaaa cgatactgct tggcggtcct
2276101 ggactcgttg accgtgaagc tctcccgcgt cgaggccgcg atcggaatga cgcgaaatgg
2276161 cactcccgca tcaccgagca gcgccatcag caggctcccg gtcgacccgc cggccgggaa
2276221 cagtgctgtc gagcaaccgc cgaggacatg cacaatgcgg gcgacattga taccgccgcc
2276281 gccgggatcg tagcgaggtg cgccacaacg cattttctcg gtcgggcgca ccacgtcgac
2276341 gctcgtcgtg atgtccaagg cggggttcat ggtcaaagtg atgattcgcg gcttgccttc
2276401 gtcccacgcc gctggctccg tcatcgtcgt ggactctgcg ctacagaccg gtcgggtagg
2276461 tttccgggtt ctcgccggcg atccaccggc tcgtcacctc gagaggttcc agggcacggg
2276521 tctgatcgat gtggatcatg gcgtcgaact ggtcggcggg ccgcacgtgc aagtagtgac
2276581 tttgccgttc cgttgccggt agataaacga cgccgatggc acgtcccaac cggacaacgt
2276641 ccagcggggc ttcggcgtcg cggcttagcc gcgctgacac caggaaactg tctgcagtct
2276701 ggtggaagag ctcctcgaca ctgccgtgca gtgccggccg aaccgctttg cgttgggcga
2276761 taccacccca ttcgctggcc gcggtgacgg tgcccgtgta cgtgctgaat ccgatgctgc
2276821 gcgactcgtc accgtatcgc tcacggacta tctggccgag ggtgagctgc ccgtcggccc
2276881 acacctcggt agcgcgtgcg tcacccacgt gggagttatg agcccacacc actattcgcg
2276941 ccggcggcgc atcgaggtgt cggtccaaat gcgtcagcaa actgccaagg gtctgcgcca
2277001 tgtgctggtc gcgcaggttc cacgaggtaa cgcgtccact gaacatggcc cggtaataca
2277061 cctctgcgtc gcgcaccgtc tgcgcgtttt gctgggcgta gaacagttcg tcctcggcaa
2277121 gcagcccgtc ttggcgcgca tacgccaggg cattgcgctg aacgtcgacc agttgctcga
2277181 cggcttcacg ttcgcacgac ggaccggcgc cgaatgcggc cgcgaatccg tacgcctgac
2277241 cgtcatcggc gcaggcatgg tcgaagcacg cataccgggc ccgcgcccgt gccgccgcac
2277301 gcgggtcgac cttgtcgaga tagctgatca cctcttggat cgaccgatgc aggctgtaaa
2277361 gatccagacc gtagaagccg gcttgccgca gcgcgcccga ctcgtagcgc tggttgcgtg
2277421 tgcgcagcca ttccacaaaa tctcggacca cggtgttgcg ccacatccag gcgggaaacc
2277481 gctcgaatcc gctaagcgcc tcgtcagcgt tggtgtcctc gccgaggccg cgaacgtacc
2277541 gattgacccg gtaggcgtcg ggccagtccg cctcggcggc taccgcacca aagcccttct
2277601 cctcgatcag ccactgtgtc atggcggccc gggcctggta gaactcgtgt gtgccgtgcg
2277661 agctttcgcc gatcaacacg attcgtgcat cgccgaccag ctccgccaac acctcgtgcg
2277721 tcggaacacc cccgggggcg tcgatcgcga ctctgcgcag aacatcggcc gccgttgacg
2277781 ccgcgggccg gcgcagcgac ggcccagcgg tcggggtggc caggagccgg cggacctcct
2277841 cgtcggtgac ctgccggaag tcccaaaacg actcaccgac ggccaggaac ggggtcggca
2277901 tggtcgcgca cacaacgtcg tcgacgaggc cggcgaactc ccggcacgtg gactccggcg
2277961 ccgccggcac ggcaatcacg atctgcgctg gttgcgcatc gcgcaatgcc tgtaccgccg
2278021 cgaacatgct tgcgccggtg gccaaaccgt catcgacgac aatgaccgtc ttgccggtga
2278081 tatcggtggg cgggcgctcg ccgcggtagg cggactcgcg ccgaagcagt tcccgaccct
2278141 cacgttcggc gatgtcgcgc agttgctgcg gtgtgatccg caggccccgc acgacgtcgt
2278201 cattgaccac gacgcggccg ccgctggcca gtgcaccaac ggcgaactcg tcatgccccg
2278261 gggcaccaag tttgcgcacg acgaaggcgt ctagcggggc atgcagtgcc gcggcaacct
2278321 cccatgcgac cgggaggcca ccccgggcca agccgagcac aatcacgtcc ggctggtccc
2278381 gataggcggc gagtaattcc gccagcaccc ggccggcctc gcggcggtca cggaacacgc
2278441 gccgcggcga gcgccgggtg acatcagccg ctgcggtcat cagcacggac ccagtggtca
2278501 gttggtggac cggatctgaa tgtgcttttc ggttggcttc ccttccgaaa ccgccaccga
2278561 cacagtaaga atgcccttgt cgtaggtggc cttaatgtcg tcctcgtcag cacctaccgg
2278621 cagcgacacc gtgcgaacga aggaaccgta cgcgaattcc gagcgaccgt cgaagtcctt
2278681 ctgctcggtg cgctcggcct tgatggtcag ctgaccatcg cggaccataa tgtcgacgtc
2278741 cttgtcgggg tcgaccccgg gaagctccgc gcgtacctcg tagcgcccct ctttcatctc
2278801 gtcttccagc cgcatcaacc gggtgtcgaa ggtgggccgg agtccggcga atgacgggaa
2278861 ggccgcgaac agctcagaaa actcggggaa gagggaccgc gggtggcgct gaacgggaag
2278921 ggtggtggcc atttgatgcc tcctaatcga tggaaacgga tgcctttgat ccgaccagcc
2278981 catcgtggcc agggctaggg acagaagtcc ccgaagcgcg ggccatttgt ccgcgcccgt
2279041 cggtgatcca cttggggacc attgaccctg ttgtctgcca accgccgttc agaaagatcg
2279101 gggtgatatc gaacagcgga ggttgatcat gccggacacc atggtgacca ccgatgtcat
2279161 caagagcgcg gtgcagttgg cctgccgcgc accgtcgctc cacaacagcc agccctggcg
2279221 ctggatagcc gaggaccaca cggttgcgct gttcctcgac aaggatcggg tgctttacgc
2279281 gaccgaccac tccggccggg aagcgctgct ggggtgcggc gccgtactcg accactttcg
2279341 ggtggcgatg gcggccgcgg gtaccaccgc caatgtggaa cggtttccca accccaacga
2279401 tcctttgcat ctggcgtcaa ttgacttcag cccggccgat ttcgtcaccg agggccaccg
2279461 tctaagggcg gatgcgatcc tactgcgccg taccgaccgg ctgcctttcg ccgagccgcc
2279521 ggattgggac ttggtggagt cgcagttgcg cacgaccgtc accgccgaca cggtgcgcat
2279581 cgacgtcatc gccgacgata tgcgtcccga actggcggcg gcgtccaaac tcaccgaatc
2279641 gctgcggctc tacgattcgt cgtatcatgc cgaactcttt tggtggacag gggcttttga
2279701 gacttctgag ggcataccgc acagttcatt ggtatcggcg gccgaaagtg accgggtcac
2279761 cttcggacgc gacttcccgg tcgtcgccaa caccgatagg cgcccggagt ttggccacga
2279821 ccgctctaag gtcctggtgc tctccaccta cgacaacgaa cgcgccagcc tactgcgctg
2279881 cggcgagatg ctttccgccg tattgcttga cgccaccatg gctgggcttg ccacctgcac
2279941 gctgacccac atcaccgaac tgcacgccag ccgagacctg gtcgcagcgc tgattgggca
2280001 gcccgcaact ccgcaagcct tggttcgcgt cggtctggcc ccggagatgg aagagccgcc
2280061 accggcaacg cctcggcgac caatcgatga agtgtttcac gttcgggcta aggatcaccg
2280121 gtagcgggcg ccgccgggac cgcgtctaag caccgcagct gaatcgggcg gatgatgtgt
2280181 cgatgagcgg atccggcgat ggcgacggtg tcgcgcggtt gggcagacat cttccgcggc
2280241 tattcgtccc cggccggctg agtgacgaag tcgatcagtt cttccacccg gccgatcaac
2280301 gccggctcta ggtcggtcca gtcgcgtact tgcgaacgga tgcgccgcca cgccgcggcg
2280361 atgtcggcct ggtcggcgtg cggccagccg agcgcatcgc acacgccgtg cttccactcg
2280421 atgtgccgcg gcaccctcgg ccaggcggcc agcccaactc gttgtggctt gaccgcctgc
2280481 caaatgtcga cgtaggggtg cccgacgacc aaagtgtcgg agccgcccgg tccgcggcgc
2280541 accacctcgg cgatgcgcgc ctctttcgac cccgcgacca aatggtcaac gagaacgccg
2280601 agccgacgcc gcgggccggg ccggaacttg gcgacgatct ccaccaggtc gtcgacgcca
2280661 ccgagatgtt cgacgacgac accttcgatt cgcaggtccg ctccccatac cgccgcgatg
2280721 agttcagcgt cgtgtcggcc ctcgacatag atccggctgg cccgggccac ccgggcacgc
2280781 gcgcccggca ccgcgaccga gccggatgcc gttcgcctcg ggccggcagc cgctgcgcac
2280841 cgcggcgcgg tgaggatcac cggcaggccg tcgagtagat acccggggcc cagcggaaac
2280901 ccgcgggtct tcccgtagcg gtcttccaag tcgatgcggc catattcgac tcggaccacc
2280961 gcaccgacgt agccggtctc ggcgtcttcg acgaccatgc cgagctcgac cgggtgctca
2281021 accgagcggg gccggcgccg cccgcctgcg gcaagcacgt cggttccata gcgatccagc
2281081 acgccgcaat actagggagc ctctctgccg gtcatcgccg cgacgcgccg catgggttct
2281141 cggaaaatgc ttgtaccagt cgactttccg gcgggccaac gtcgccaacc gatactcggc
2281201 tccaacgcca tgggtgacgg gatgcccgga tcacgtgtca caccacccgc gcacccttgc
2281261 ggaagaatat ccgtaagtct aaacttacgg ttcgtgtcca cttacagatc accggatcgc
2281321 gcttggcagg cgctggcgga cggcactcgc cgggccatcg tggagcggct ggcgcacggc
2281381 ccgctggccg tcggcgagtt ggcccgcgac ctgcccgtca gccgacccgc ggtgtcacag
2281441 cacctcaaag tgctcaagac cgccaggctg gtgtgcgacc gccccgcggg aacacgccgc
2281501 gtctaccagc tcgacccgac aggccttgcg gcattgcgca ccgacctcga ccggttctgg
2281561 acacgcgccc tgactggcta cgcgcagctc atcgactccg aaggagacga cacatgacac
2281621 gcccgcgaac cgatgccatc caccaccacg ttgtcgtcaa cgccccgatc gagcgtgcgt
2281681 tcgccgtgtt caccacgcgg ttcggcgact tcaagcctcg cgagcacaat ctgcttgcta
2281741 tcccgatcac cgagacggta ttcgaatgcc atgcgggagg ccatatctac gatcgcggtg
2281801 ttgacggaag cgtgtgcaaa tgggcgcgcg tgctggtcta tgaaccgccc agccgggtgc
2281861 tattcacgtg ggatatcggc ccgacttggc ggccggaaac cgatctggcc aagaccagtg
2281921 aggtcgaagt ccgcttcacc gcgcagtccg ccgagacgac acgcgtcgac ctcgaacatc
2281981 gccatctcga ccgacacggt ccgggctggg agtcggtcgc cgacggcgtt gacagcgagg
2282041 ccggatggcc gttataccta cgccgctata ccgacctgct ctgcatccag gtgcagccat
2282101 gatcgcggca gacgacgata ccgagaagtc catgatggac atggcccgcg ccgagcgggc
2282161 cgaactagcg gcgtttctga ctaccctcac actgcagcaa tgggaaacac ccagcctgtg
2282221 cgccgggtgg agcgtcaaag aagttgtcgc acatatgatc agctacgaag atctcggcgt
2282281 tttcgggttg ctcaagcgct ttgccaaagg ccggatcgtc cgggccaatg aggtgggtgt
2282341 cgacgaattc gctgggctca gcccacagga gttggccgac tatgtcggcc ggcatctcca
2282401 accgcgtggg ctgacagcgg gtttcggcgg aatgatcgcc ctcgtcgatg gcatgatcca
2282461 ccaccaggat atccgccgcc cgctcggtca gccccgcacc atccccgcgc agcgacttga
2282521 ccgcgtgttg cggctgatgc cgaagaaccc caggctgcga gctcggccac gcatcaaagg
2282581 gctgcgactg cgagccaccg acctcgactg gacaatcggc accgggcccg aagtaaccgg
2282641 gcccggcgaa gccttgctca tggcaatggc cggcaggcca gcggcggtca gcgacctctc
2282701 cggccccgga aagcccacgc tagccggacg actcggttaa cgacagctac agcgacggcg
2282761 tgaacgggcc gccgcagtca gccagacaat cggcgtaatt ccagttcgcc aagaactttt
2282821 gacccgcctg aaatccgcgt tggtaaagag cctcgcgttg ttcggcggtg atgtcgaagt
2282881 cgatcggact cacgtcgtgg gcgggcacga agatggtgcg ccgaacggta cacggatcgt
2282941 cgatgtaggc gttgtcctga ttgctcacca gtgtttcgat cgccgcgatg cccaacgaca
2283001 ctggcccttg gaccggccgg gtaggtggaa tgcccggacg cgctgacaac ctgatcccga
2283061 acgtgggcca tcgcggttca gcgtcggttc ggtcgaacag cgccaccgga aagttcgaca
2283121 gcaagccacc gtcgacccag gtagcgccgc gcacccgaac aggctcgaac acaaacggga
2283181 tcgccgatga ggcgtgcacc gcacgcgcca ccgagaagtc gtccgggtgg atgccgtagg
2283241 agtccaggtc ccacgggatg cgaacgagtc ggcgacggga taggtcgctg gcggtgacca
2283301 ccagcgacca ggcgaactgt tcgggtgcct cgccggtgcg caagtcgcca aaggtgtgca
2283361 cgcctaggtc agcgagcaaa ccgccgagca gctgttccag ataggccccg cggtaaacgc
2283421 cgtccgacaa cagcagagaa agtcccccgc cgatcaacgg cacgtgtcct atcagattgc
2283481 ggtcgaggaa cttcgggtag tcgatgctgc gcatcatctc ggcaagccgc gtcaccggct
2283541 caccggccgt ttgtagggcc gcgaccagcg acgcgacgat cgcacccgcg ctgctgcccg
2283601 ccaccctggg aaatcggtaa ccggcatcgg ccagcgcgtc caccgctcca accaacccta
2283661 tcccccggac cccgccgcct tcacacacca ggtcgacgcg tgctgtgctc accagcgcca
2283721 cgttagcccg gaatccgacg cccgtcgacg gcgaagaagt gcaggtgtcc cggtgtggga
2283781 catagccgca cgcgactacc ccgctcgggc gggccgcggc cgtccactcg agcgacgatt
2283841 gactggtcca tttcgcagcc gcccgacacg attcggccat acaagtaggc gtccgctcca
2283901 agttcttcga ccatgtcgac gtccatctcg atgccggcgc cgcccagctc caaatgttcg
2283961 gggcgaacac cgataatgac ctcggctgcc gtaccgacga ccgcacgcgg cagcaggatc
2284021 tgccaatcac ccagtgacac cgtggaatcg gcgatggaaa gcctgaacag gttcatcgcc
2284081 ggggaaccga tgaaccccgc gacgaacacg ttgcccgggt tgcggtagag ctctcgaggc
2284141 gaagcacact gttgcagcac accgtcagac agcaccgcga cgcggtcacc catcgtcatg
2284201 gcctcgacct ggtcgtgagt gacatacacg gtggtcgtac ccagttgccg ttgtaacgcg
2284261 gcgatctgat tgcgggtttg cccgcgaagt ttggcgtcaa gattggacag cggttcgtcc
2284321 atcaggaata cctgtgggcg ccgcacgatc gcacgaccca tcgccacccg ttgccgttgg
2284381 ccgccggaga gatctttcgg cttgcgatcc agataagatt gcagatcaag caatttcgct
2284441 gcggcaagca cccgctcgcg gatctcggcc ttgccgatct tggcgacctt caacgcgaag
2284501 cccatgttct gcgccaccgt catgtgcggg tagagggcgt agttctggaa caccatggcg
2284561 acatcacgat ccttgggatc gacctcggtg acgtcgcgct cgccgatccg gatacgccca
2284621 cagtccagcg tctccaagcc agccaccatc cgtaacgacg tcgtcttgcc acatccggac
2284681 ggccccacca ggacaacgaa ctcgccatcg ccgacgatca ggtcgagccg atccagggcc
2284741 ggtcggtccg tgccgggata gcgccgggtt gcctgctcaa aactcaccga agccatggtt
2284801 acccgccgag cccagtcacc gcgataccac ggacaaagga acgttgtgcg accgcataaa
2284861 ggatgaccaa cggcaccagc atcagcatcg acgccgccat cagcaccggc caccgggcga
2284921 cgtattcgcc ccgcaatcgg accaggccaa gggtgagcgt cgccaggctg tttcgctgga
2284981 tcatcagcag cggccacaga aagtcgttcc acacgttgac ccaggtgagc acacccagca
2285041 ccagcaccgc gggacgtgaa tgcggcagca gaatccgcca gtagatctgc cacggcgagc
2285101 aaccgtcgag aatcgcggct tcctcgagat cggtcggcag cgtgcggaag aactgccgca
2285161 tcaggtaggt accgaacgcg ctaccgaaca atcccggcac gatcatcgcc cacggcgtat
2285221 ccacccaccc cacgatccgc atgagaatga cctgtgggat gacggtcacc gtcaacggca
2285281 ccatcaaagt gctcaagtac aagacgaaca acgtatcgcg gccccggaac tgcagtcgcg
2285341 cgaaggcata accggccaac gagcagaaga agacctgccc ggcggtgaca catccggcat
2285401 acagcacggt gttgaagaac atccgccaga acggcatcaa cgcgaacacc tcgcggtagt
2285461 tggaccattg cggatgcgac gggaacagcg tcggctcggt cacctcgccg tccgccttca
2285521 gggagcccga cagcgcccag atgataggga acagcgcgca ccaagcgatc ccgatcagtc
2285581 ccgcgtacag ggcaagccca cgaatgaagt ggcggtggac tattcgatca gcccagccca
2285641 cgggacgcct cccaggagcg ccggtgcgta attcgcaact gcagcacggt caacaccagc
2285701 aagatggcga acatcaccca cgccaacgcg gacgcatagc cgaattccag gaacgaaaac
2285761 gcgtgctgga acagcatgat gcccaaaaca taggtagccg tctcgggacc accgttggca
2285821 ccggtaagga cgtagacaag gtcaaacgcc tggaacgcgt ggatgatcga tatgacaacc
2285881 acgaatgaca atgccccccg gatcagcggt accgtgatgg acacgaactg gcgaatctcg
2285941 ccggcaccat cgatcctggc cgcctcgtac acagtctccg gaaccccctg catcgcggcc
2286001 agcaggacga ccgtggcgaa gggcacactg cgccagacgc tgaccaggca aagcgagacc
2286061 atggcccatc ggggttcgat tagccatggg atggggccga ttcccagcca gccgagcatg
2286121 atgttgagta ggccattgtc ggtgttgaag acgaactgcc agacgaccgc catcaccacc
2286181 gaggaaatcg ccaacggcaa gaagacgacc gtccgaaaga ggctgatgcc tttgattttc
2286241 cggtttagaa aggcggcgac gacgaggctg acgataacgg tcggtaccac ggtgccgacg
2286301 gtgtaaaccg cggtgttgac cacggcgatg agaaacagcg gatcagaagt gaagaggttt
2286361 ctgaaattgt ccaacctcac gaacgtcgca tgcgtaaaca agtcccactt ctgaaagctc
2286421 atgtacagcg agaatcccag cggaaacagc atgaacacca caacggcagc caagttcggc
2286481 gcgacgaaca tacgccccgc ccacgcgcgt cgccccctgc gccgtgtcat ggattgcgca
2286541 gcacttcatc gacggcctgt gatagcccgg tcagcgaggt cgccggccgg gatccacgca
2286601 gcacgggtcc gaagtagcgg tccatcaggg cggcgatctt ctcccaggcc ggggtcaccg
2286661 gcaagccttc cgaataggcc ggcccctcgc tgagcacggc aagattgcct accctgcggt
2286721 gggcgttggc gaatccgtgc gagttgatcg ccgatctcag caccggcacg aacaggcggg
2286781 attcgccgat caatgcctgc cccaccgggc cggtcgcgaa ctttacgaat tcccacgcct
2286841 ggtccttgcg tcgactggtc gccgcaatgg ccagcccggt gacaccgata tctgaacagg
2286901 cggctcgtcc gcgcggaccg atgggcagtg gggcgacgtc gaagtccaga ccgtcggcac
2286961 ggtcgaacgt ctgatatcgc cagtgcccgg ccaacgcgat cccggccttg cccacagaaa
2287021 acaggtccgc cgtcgacatc gactgctgct cagcagcgct gggggccacc ttgtgcttgt
2287081 tggtcaggtc ggcgtagaac tgcaccgctt cgaggaaccc atcgtggtcg aaattgaggt
2287141 gggtgggatt catccgcgga accgaccacg gtacaccgtt attcatggcg aacaacccgg
2287201 cagcgtagaa cgagacccac gcgttgacga agccccattg cctgtcccgt cccgaccggc
2287261 cctgcttggt aagcgcctgg gcggcatcca ggaattcggc gaagctccat ggccgttccc
2287321 agctaccggg cggcggtggc acgccggcgt cgtcgaatag ctgtttgttg tagaacaaga
2287381 agttgccgga ccattgctcc ggaaaggcgt actggcctcc gttgaacgtg aaagtctcat
2287441 acagggcccc gatgctgtcc gatttcagct ccgcggcgaa agcctggtcg cgcgccaata
2287501 gcgtgttcag gtcaagcaac accccccggt cggccagttc ggcataggtc agttcccatg
2287561 ccatcagcac atccggacac ttgccacccg cgcaaaacgt tgcgagctgc tgcatgacgc
2287621 cgggtccgga caacagggcc cgtaccttga tatcgggata gcgccgctgg aattcgttga
2287681 cgacgcgcat ccggggacgg agctcgtccg gattggctgc aaaaaagaaa gtcaacgcgt
2287741 catcgtcatc ggcagcacac ccagcggccc agggagccag cgaggccgca gtaagcgcgc
2287801 ccgcaccccg taacagactg cgccgctcga acggcttatt gaccatcgtg ctcccgattt
2287861 tgggtcctgt ggtacaacga ccgtcaggct gggaagtacc gaatccgatt gatccggttg
2287921 ccgcgccacg gcacgtcggc gaacatgatg ccgcgccggt ggtccgacgc gagcgacacc
2287981 gcgacggtgg atccggcacc ggtcaccttg gtccagctag ccccgcgcag ctgctcgaac
2288041 agctcgacaa tgtcgagtag ctcatcctcg cctaaagtca ttgtggcagt gcgtgataac
2288101 gcgtgatacg cagcggactt gtctgcccgg gacgcggcgt tgaggaacgt ttccaccagc
2288161 ttcttgtgcc gccggcccgc ccggcgaaag ccggtcagga atcctgcggt gccgcccaac
2288221 ccttgattgc ctagcagcgc tcgcgacagt tgcagggcgg gtcttgtggc ccccgatccc
2288281 gtgcgcagaa actgcagcat catcgccggc aactcccagt acgcccgcag tgcggcaatc
2288341 tgccactcgc cggtaaccgg tcgtaggtca tagcgtagga aggcgggaat gaacaccgtc
2288401 acagccgagt ccatcgcgac ctcgagttcg agatcgcgca gcaccaccgt gccggagacg
2288461 atatccagat cgcgatggaa cgtgatatcc cgcggcccga tgaaggtgtc gtagaagcgg
2288521 ccgatggcct catgccccac ctgcggctgc gaacccaccg ggtcttcgac ccgcgcgtca
2288581 ccggtgaaca acccgaccca gccggcgcgg tcgtgcgcgg cggccgcttg cggcgagcgc
2288641 tccaccgccg ccaacagttc atcccggttc ggcggtgcca tcaggagctg caaaccaact
2288701 cgacgctggc ggtgcgcatc tcctccagcg cggcgacggt ggtatcggcc gacacacccg
2288761 ctgtcaggtc caccagcacc ctggtggcca agccattgcg taccgcgtcc tcggccgtct
2288821 ggcgcacaca atgatcggtg gcaataccga ccacatcgac ctcatcgacg ccgcgttgcc
2288881 gcagccaatt cagcagtggc gtgccgttct cgtcgactcc ttcgaagccg ctgtacgctc
2288941 cggtgtaggc acccttgtag aacaccgcct cgattgccga cgtgtccaga ctgggatgga
2289001 agtccgcgcc gggagtaccg ctgacgcaat gcggtggcca cgacgaggaa tagtccggtg
2289061 tgccggagaa gtggtcaccc gggtcgatgt ggaagtcctt ggttgccacg acgtgatggt
2289121 agtccgccgc ttcggccagg tagtcgctga tggcgcgggc cagcgcggcg ccaccggtta
2289181 ccgccagcga gccaccctcg cagaagtcgt tctgcacgtc gacgatgatc aacgcccgca
2289241 tacgtccacc atacgttcgg gcgactgccc gggcagtttg cctaccgacg cggcagccac
2289301 agatataggg tccatgacgc cgcgacgatc gcgaacatga ccagctgagc ggcggccacc
2289361 caaccggcgg gatagatcac gccggtgatg tagtgagcga caaatccgtc cggtgacaga
2289421 ggtgtcatcg cggccttggt gcgagcccag cgctccaccc aggtcagcgg gcagtcgacc
2289481 cgcttagcgg cgatgccgat cccccatatc accgccggaa catgcagcca catcgtgcgt
2289541 cgccaccgca gggcaaggaa accgccggca aggacgtaag cgatgaaagc gaagtgcatt
2289601 accaccgttg atacaacgac ggtttcgtac atctctcggg ttgcctttcc aggtcgcggc
2289661 gctccggcca ctgacagaaa aggttcaatt cgccagcgaa aacccgtccc atgcgatccg
2289721 gcggtgctga tgcggatcga actcgatgcg gcacctgcgg tcgaaaacca ggacggcacg
2289781 gtcgtcttgg gtgtaagccg gccagtcgtc gcccggaaca ccaatttggc tgaaacaacg
2289841 ccagcggcgt tgcacctcgt tgctgacccg aagggcggca cggcggtcgg cggcggcggt
2289901 cagcaatgcg ccaaatctgg tgcgatagat gtcgaagacg gcaaacagtt cggtggcatg
2289961 ggtggcgccg aaacccgacc agcgcagcgt ccgtggcgcg tagtcatatc ggtataggta
2290021 ggtgggcgca ttggcgccgt gagcctcggc gatctgccag gccgccgagc taaaggcgaa
2290081 gtcaccaccg agctggatgc acgccgaggg cgcagggtaa ttcgggtagg cggcggtaat
2290141 gcgttcacga tcggccggtt tcatgcccga cagtagctct tcaaccatcg gttcgttggt
2290201 cggcagcatc cccagaaagc gggtgaacaa ccgaccctct tcggcgttgg ttcccacgat
2290261 cagcggaacc gcgtgcaccc ggccggaccg catcgcctcg acggggtcca tgggcaggta
2290321 gtcgtcgccg aacaccggac caatcgggaa ggcgcccagc cttttccgca ttccctggcg
2290381 aatcaggtgg tgttgggctt ccaccagctg cgcgggggac gcctgcatca acgcattggc
2290441 ggcatcctgg gtacgcgcgc cgatcagatt ggcaaagcgt gccgcgaact cggcggccac
2290501 ctcgcgcgaa cgcaccatgc ccgccgctgg gctttccgag atcgccctgg cgaataggcc
2290561 tttggcggct ggcaccgcca acagtgtggc ggtgatatgc gcgcccgcgc tttcgccgaa
2290621 aatggtgaca ttgcctgggt caccgccgaa ctccgcgatg ttgtcgtgga cccaacgcaa
2290681 cgccaacacc aggtcgcgca ggtacacgtt gctgtcgagg gtgatctgcg gtgtcgacaa
2290741 ggacgacagg tcaagacacc ccaacgcgcc cagccggtag ttgaccgaca cgtacacgca
2290801 gccgcggcgt gccaacgctg cgccgtcgta tatcggggtt gccgagctgc ccaggatgta
2290861 gcccccaccg tggatgaaca ccattaccgg cagcggctgg gtggctggct cttcgggtgt
2290921 gacgacgttg agggtgagac agtcctcgct gcgggtctgg tacctgccga tgcccatcac
2290981 ggtgtagcgg cgctgctgag gagcacagtt ggcaaacgtg tggcagtgcc gtacgcccgg
2291041 ccagggctgc gctggctgcg gcgcccggaa tcgcagcgag cccaccggcg ccctggcgta
2291101 agggattgat cgccaacggt gcacaccgtc gcgcgtgaag ccttcaacga tgccggtggc
2291161 cgtgcgggcg cgcacggtgc gctcgtgcat agacccgacg gtagccgact ccagggccac
2291221 gcggcatgcg cagtgcagga atgggggcgg ggcggctagc ctgtcgggat gcggatcgcc
2291281 gcgctggtcg cagtgtcgtt gctgattgcg gggtgctcgc gcgaggtcgg cggtgatgta
2291341 gggcagtcgc agaccatcgc cccgccggcg cccgccccgt cggcggcgcc gtcaacacca
2291401 ccggccgcag gagcgccgat caccactatc gtgtcttgga ttgaggcggg tcacccggtt
2291461 gatcccgccg cctatcacgt cgccacccgc gacggcgtca ccacccagct tggcgacgac
2291521 gtcgcgttca gcgcttcgtc gggcacggtg gcctgtatga cggatgccag gcacactagc
2291581 ggcaccctgg cctgcctggt ccgactcgcg aacccaccac cccggcccga gacggcctac
2291641 ggcgaatgga agggcggctg ggtcgacttt gacggcatcc acctgcaggt cgggtccgcc
2291701 cgcgccgacc cgggcccgtt cgtctacggc aatggacccg agctggccaa cggggacacg
2291761 ctgtcgatcg gggactaccg ctgccgctcc tatcaagcgg gcctgttctg cgtgaactac
2291821 gcccatcagt ccgcggtccg gttcgccagc gccgggatcg agccgttcgg ctgcctgaag
2291881 ccggcgccgc cacccgacgg cgtgggcgtt gcgttcggct gctgaggtgc acccgtcaca
2291941 agctgacacg acgaactagg ttcagcgact gagatcgctt cccggaagcg ccggcccatc
2292001 ttcggacgcc agctcaacca catgaatttc cccggtagcc ccgtcgacct ccaccaatgc
2292061 tcctggtggc agaaaccggg tagctccctg ggcgtcgacc acgcaaggga atccgaactc
2292121 gcgggcgacc accgcggcat gtgacatcgg gccgccgagc tcggtcacca cggcggcggc
2292181 gtagcagaag gccgcggtgt atccgacgtc ggtgacctcg gcgaccagaa tctcgccggg
2292241 ctgcaaatcg tcgatggtct ccggacgcac gatccgcacc cggccgcgca cccgtccgcc
2292301 gcagacgccg actccgcgta gagtgtcccc ggctgccagc gccgccgccg acgaaggcga
2292361 cggttcccag cttccgctga acaccgtggg cggaacgatg ccggcaagcc tgcgctgttc
2292421 ggcacggcgc cgagccacca gccccgacac gtctgccggc agcgcatcga tttcatcgac
2292481 caagaggtag aacacatcgt ccggggtgtc gaagacgccg gcctcggtca gccggcgccc
2292541 gtactcccgc agcagagcac gcagcaccca gatggcacgc accatcctgt cgcggcggac
2292601 ctcgcggtcg cggagctggc gggccgccag caacgcaacg ggcttggccc gcaacggaat
2292661 caccggcgtc ggcggttgcg gcgctggcac cgcacgtagc gtcttggcta ccatccgcac
2292721 cagcaactcg gggttgtcgg catagctggt ggcggccatc tcgacttccg ccggaccgcg
2292781 gtgcccgatc agcgtcagct cggccagcac cgcggaatgg aactccggcg cctcgacagc
2292841 tagcttgtcc agacgctccc ccggctcggc cagcaaccga atcacgaccg gatcccgccg
2292901 tgccgcggcc accagccgct gcaccgcctc caccgatcgc gcgctgacca actccggccc
2292961 ggccgccggt gcggtgtccc gcccgcacaa tcctcgcaac aacacgttga acgccgcaca
2293021 cagcatgaac gaccccgagg ccagcaccca gccgtgcacg acgtggtcac gtgccaacaa
2293081 gatcaggctc aacaaccggc ggtcgtcgtg ggtagcgagg ttatcgaagg cgagacgctc
2293141 caggcgatcg acgtcggcga cataggcatc ggtgtcgcgg ggtgagccgg cggacaggcc
2293201 caccaggttg acgccgaaca ccccgatatt gcgtagcgta cgtaaccacc tgcgggcacg
2293261 gctggattcc gatggcggtc gctgcgcgcc aaagatgggc agcgaagcca tgctgggtcc
2293321 gaagaacccg ctgttgctga cgatcgtcgc cggcttggcg aaggggacgg ttgctgccat
2293381 gaaatgcgcc gacgtgatgg ccccgtacag ccggtgggcg aacaccgcga cggtccgcat
2293441 ggcgatttcg cgctggatca ccccgctggg ccgcagccgc tcggcgatgc ccaccccgcc
2293501 ggcacgcagg ccccgcacag tcaccgatgc cgacgacggc gagaacgggc cgggcagcgc
2293561 ctccgagagg ttggtggcca gataggtcgg gaagcgcggg tcgatcggcg tgtcgaactc
2293621 gccgttggcc ccttctgggc cggccaatct gggtgcgaca ccgtcgtctg ccggggagtc
2293681 gaccgccgga aggtcctgga tgttagccag ccgccaaggc agggaaaatg ttcgctttcc
2293741 cagaccgatc cggccacgca ccgccagggt gaagtcttcg agacactcct cggcgttcca
2293801 ggccggctgg aatccccagc ggtcacgcag gagcgtgaca tccatcaatg gcgcgctgtg
2293861 caggagttcg agttcggcga acgaggtgac acgtcgtagc actggggagc caataggcac
2293921 catgggccgc ccgagcgcgg ccgcaatgcg ccgaaacgtc aactcgccag gggcggcgag
2293981 attaacaggg ccgctgtcga ttaccgtgtc cagtagcgcg cgaaccaaca gccgctgcgc
2294041 gtcgtcggag tggacgactt gtacgacgcg atcagcatac ccggcgggta acaccggcag
2294101 agcaaacagc cgctgcaccc agttgtcgac atttcgaccg aaaatgagcg cgcagcgcac
2294161 ggcgacccat tccaggccgc agtcggccag catctgctcg acgcggggtt ggtgaccgct
2294221 ggacgtgaaa acgatgcgcc cggttccggt ctcggccatc gccttgagga cattggcggt
2294281 gccgtcgata ttgatgtggt cgtttcggcc acgcacccac gcacaatgcg cgaccacatc
2294341 cgcacctgtc atagcacttt cgacggcggt ggcatcccgg atatcggccg caatgaaatc
2294401 cgctgagctc ggccagctgt ccggtcgatg acgtgcgatt ccgacgacct cgtgaccctg
2294461 actcagcaat ctggcggtca ggccgcggcc gagaactccg ctggccccgg tgacggcgat
2294521 tctcacggtc ctactcgtcg tcgttccgaa acgccgcgtt gaccaggtcg tcgaggtcca
2294581 tgtccgcgat ctcttgttct gcggtcggcg ccaacgccgg gtcctggccg ctggtttcgg
2294641 tttcatttgc cagcgcgagc aacagatcca gcactcccgc ctgccgtaag cgcttgaccg
2294701 gaatggacgc cacaatgcgt tgtagttcgg cttccccggc cgccacggct gaagtgtctt
2294761 gcggtgatga gccgagcagt tctcgacgca tatagccggc cagcgccgcg gagttggggt
2294821 agtcgaagat gagcgtgggt gaaagcgcca ggccggtggc ggatttgagc cggttgcgca
2294881 tttcgaccgc ggtgagcgag tcgaaaccca actcctggaa tgccctatcc gggtcgatgg
2294941 cttcggggct ggcgctaccc agcacggtgg cgatgtgcga gcgcaccagg tccagcagga
2295001 cggcgtgttg ctcgtcttcg ggcagtcctt ccaggcgttg cagcagagcc gatttcgatt
2295061 tcgccgcggc caacgagtca tcgacctggc gcctggtcgg cgcgttgatc agatcgacga
2295121 acatcggcgg caacgtgccg ccatcgaact tgaccttcaa cgccgcaaag tcgatgtggg
2295181 cgggcagcat gaatggctcg tcgacgatca ttgcggtgtc gaacaattgc agggcgtcag
2295241 cagacgacat cgccacgatg ccgtcgcggg cgaagcgttt gaagtccacc gtcgccaggc
2295301 cgccggtcat ggcgctggcc tgatcccaca gaccccagcc cagggagatg gccggcagcc
2295361 catgggcccg ccggtgggcg gccagcgcat ccaaaaacga attggcggcc gcatagttgg
2295421 cctggcccga cgatccgacc agcccggcca tcgacgaaaa catgacaaac gccgacacat
2295481 ccaggtcgcg agtcaactcg tgcaggtgcc acgccgcgtc caccttggac cgcaacacca
2295541 catccacccg atccggtgtc agtgacatca ccaccgcgtc gtcgagtgcg ccggcggtgt
2295601 ggatcacgcc cgacaatgga tgctgaaccg gaatatcggc gatcaccttg gccaacgccg
2295661 ctcgatccgc cgcgtcacag gccaccacct gcacctgcgc accggcggcg gccaactcgg
2295721 ccaccagctc cgcagccccg ggagcatccg ggccgcgccg gctcaccaac accagattgc
2295781 gcaccccatg acgagccacc acgtgacggg ccaccgccga acccgccatc ccggtgccac
2295841 cggtgatcaa caccgtgccc gccgcccacg agccgggcat cagcatgacg accttgccgg
2295901 tgtggcgcgc ctggctcaga taacgcaacg ccgcaggcgc gcaccgcacg tcaaaagtgg
2295961 tgaccggcaa cggccgcagc accccatcgc cgaacagcgt ggcgagctcg gcaaggatct
2296021 gcgcaatgcg gtccggtccc ggttcgaata ggtcgaaggc gcggtagcgc acgcccgggt
2296081 actgctgggc gatcacgccg gggtcgcgga tgtcggtctt gcccatctcc aagaacaccc
2296141 cacccggtgc caccagacgc agcgacgcat ccacgaattc accggccagc gagtccaaca
2296201 ccacgtcgaa ccctcgaccg ccagtggccg cgcggaactt gtcctcgaac tctaggctac
2296261 gtgaatcgga tatgtggtcg tcgtcaaagc ccatggcgcg caaggtgtcc cacttaccct
2296321 tgctcgcggt cgcgaacacc tccaacccca gatgccgagc cagctgcacc gccgccatgc
2296381 ccaccccgcc ggtgccggca tggatcaaca cgcgctggcc cgacctagca gcggccaaat
2296441 ccaccagcgc gtagtgggcg gtggcgaaca ccaccgaggt ggtggcggcg gccgtgtgcg
2296501 accaccccgc cggcaccttg accagcagcc gctggtcggt gctggcgacg gttccggtgc
2296561 cctcggggaa caggcccatt acccggtctc cgaccgcgaa agatcccttg ttcaagctgg
2296621 tttcgataac gacgccgcag gcctcaacgc ccatgaccgc gtccggatcg ggatacagac
2296681 ccagcgcgat catgacgtcg cggaagttgg cggcaatcgc ggacaccgca actcgaacct
2296741 gcccggggcc cagcggcgcg tcggcatcgg gaatcagctc cagccgcaga ttctcgaagg
2296801 tgccggcggt gctcatcgcc aaccgccacg gccggtcact cggaggaacc aacagcccgc
2296861 ccaccgcgcg gctaccgtgc acccgcgccg tataaacctc cccgcgccgc cacaacacct
2296921 gcggctcgcc tgtcgtcact accgccgcca gggccgaatc gtcgagcggc gcatcggaat
2296981 cgaccagcac gatccggccc ggatgctcgg tctgcgccga ccgcaccaat ccccatacgg
2297041 cggcacccgc caaatcggtg acatcttcgc ccggcaatgc caccgcaccg cgggtcatca
2297101 ccaccaaaac ccctgcccca tcacgggtta gccacgactg caacacatca agcaccgaac
2297161 tcgtggcggc atacacgccc gccactacgt caccggccag aggcaccgac tcaaacacca
2297221 ccgccgccga gtcctccgtt gtcccccagg cgcacaccgg tagcggctcc accgcggccg
2297281 atggctgcgg cgaccaggtg acctcgaata gccggtccgg acccgagctc gacaccgccg
2297341 cccgcaattg ctgatcggtc accggtcggg ccagcatgga agcgactgac aacaccggca
2297401 atcccaaccc atcggccagc tcgatcgaca ccgccgacgg acccactggc gcgatgcggg
2297461 cccgcaccgc cgacgccccc gctgcatgca acgagacccc ctgccaggag aacgggacca
2297521 acaccgaacc ttggccacgc tcggcgcttt ccgcgctcaa caccaccgcg tgcaaggccg
2297581 catccagcag caccggatgc accccgaagc cggtgaccga gaccccggca tcggcgggca
2297641 acgccacctc cgcgaacacc tcatcacccc ggcgccacat cgcggtcagt ccccgaaacg
2297701 ccggcccgta gccgtatccg cgctcggcca gctgctgata gccgtccgcc acctcaaccg
2297761 ggacggcgcc cgccggcggc cacatcgcta gatccgcggt cggttccgcc gacccggcgc
2297821 gcagcgcgcc ctcggcgtgc aacacccagc cggtaccgac gtcaccacgc gaatacaccg
2297881 acaccccgcg cacgccggac tcgtcgggac cattgacgac cacctgaacc gccaccgaac
2297941 cggatgcggg caacaccaac ggcgcggcca gcgttaattc gtcgacaacg ccacaaccca
2298001 cttcgtcgcc ggcgcggatc gccaactcca caaatcccgc tcccgggaag atcgtcacgc
2298061 cggcaacgga gtggtcggcc aaccagccct gcacgctggg cgacagccga cccgtcaaca
2298121 ccaccccgcc cgaggccggc agatcgatca ccgcgcccaa gagcgcgtgc tcactggccg
2298181 ccaaccccaa gccggccgcg tccgccgcga caccatcacc ggacagccaa aaccgccgcc
2298241 gttggaaggc atacgtcggc aactcgacaa actgcgcctc gcctaccaca gcgcgccaat
2298301 ccaggtccat accggtgaca aacccttgcg cgacggcgtt ggtcaacgtc gccggctcgg
2298361 ggcgatcctt gcgcagcgca gacatcgttg tcaccgcaac gtcgggcaac gactcttcga
2298421 tcgacgcaac aaggccaccg ctgggcccga cttcgaggaa tcggctgcct ccggccgcct
2298481 gcgcgaagcg cacactgtcg gcgaaccgca cggcttgccg gatgtgacgt cgccagtagg
2298541 ccgctgatcc gaaatcgtcg cccgccaact gcccggtcac gttggagatg actccgatgg
2298601 tgggccggcc gatggcgatt ccggcagcga cggctgcgaa ttcgtcgatc atcggatcca
2298661 tcaacggcga gtggaacgcg tgggaaaccg ccagctggtg gactcgtcgt ccgtcggcgc
2298721 gcagctggtc ggccaccgcg gccacggcgt tttgtgcacc cgaaatcacc agtgacgctg
2298781 gaccgttgac cgcagcgatg tcaacctcag cgctcagcag cggccgcacc tcttcctcgg
2298841 cggcttgcac ggcgaccatc gccccaccgg ccggcaacgc ctgcatgagc cggccgcggg
2298901 cagccaccaa caccgcagcg ttctccaacg acaggacacc ggcgacatgt gccgcagaca
2298961 actcaccgat cgagtggccc atgacaaaat ccggtcgtac accccaggat cccagcaacc
2299021 ggaacagggc aacttccacc gcgaacagcg cgggctgcgc gaattccgtg ctgttcagta
2299081 ggttttcgtc gtgaccccac atcacttcgc gcagtgggcg cagcagatgc cggtcaagtt
2299141 cgcccactac ggtgttgaac gcctcggcga acaccgggta tccggcgtgc aatcccattc
2299201 ccatgcccag ccattgggag ccttggccgg ggaagacgaa caccgtctta cccgccgcag
2299261 tcgccgtgcc ccgaacaacc gagccgccca actggtcacc cgccagctca tcgagcccgg
2299321 ccaacaaccg atcacggtcc ccgccaacca ccaccgcccg atgctcaaaa accgaacgac
2299381 ccgccaacga ccaccccaca tcggcaacat cgaggccatc atcgccacgc acgtacgcgg
2299441 ccaaccgagc cgcctgcccc cgcaacgccg actccgactt cgccgacacc acccacggca
2299501 ccaccggccc cgcccaacca gcctcccgcc gcggcaccac cggcaccgcc tcgataatca
2299561 catgcgcatt agtgccacta atcccaaacg acgacacccc cgcacgacgc gtccgagcac
2299621 cagcaggcca cacccgcggc gcggtcaaca actccaccgc ccccgccgac caatccacat
2299681 gcgggctagg cacatccacg tgcaacgtcg ccggcaacag ctcatggcgc atcgccaaca
2299741 ccatcttgat caccccggcc acccccgccg cggcctgcgt atgacccata ttcgacttca
2299801 ccgaccccaa ccacaaaggt tctcccggct ccccccgatc ttgcccataa gtggccaaca
2299861 acgcctgagc ctcaatcgga tcccccaacg tggtcccggt cccatgcccc tccaccacat
2299921 ccacctcggc cgcgctcaac ccggcattgg ccaacgccgc ccgcaccacc cgctgctgcg
2299981 aaggaccatt aggcgcggtc aacccattcg acgccccatc ctgattaacc gccgacccga
2300041 ccaccaccgc caacaccgga tgacccaacc gccgcgcatc cgaaagccgc tgcagcacca
2300101 acatcccacc gccctcggag aatccggtgc cgtcggccgc cgcggcgaat gccttgcagc
2300161 gcccgtccgg ggataatccg cgccagcggc tgaattccac gaagatgtcg ggtgtggcgt
2300221 tgacggtgac gccgccagcc agcgccagat cgcactcccc cgaccgcagc gatcccaccg
2300281 ccatatgcaa cgccaccaac gacgacgaac acgccgtatc caccgacacc gccggaccct
2300341 ccaaccccag cacataggcc acccgacccg aggcgacgct ggacaattgg ccggtcagcc
2300401 ggaagccttc taccggctcg gcggcgaaca tgccgtagcc ttgcgtcatt accccggcga
2300461 ataccccggt ggcgctgccg cgcaatccgg tcggatcgat accggcccgc tccaacgcct
2300521 cccaggacaa ctccagcaac atccgatgct gtggatccat cgcgagggcc tcgctcggcc
2300581 ccaccccgaa gaaggcgggg tcgaagtcgc cgaccccgtc cacaaagccg ccggtgcggg
2300641 tgtagcacgc acccgcggcg tcggggtcgg ggttgtatag cccggccagg tcccacccgc
2300701 ggtccgccgg gaattcggag agcacgtcgc ggccctggat cagcatgtcc cacatgtcgt
2300761 ccggggaatt caccccgccg ggatagcggc acgccatgcc cacgatcgcg atcggatcct
2300821 cgctcgtggt gcgtaccgcg ggtgtgtgct tgatttcctg tgggaggccg gcaagttcgg
2300881 tgcggatata ggaggccagc cgattgggtg tcgggtagtc gaagatgagc gtgggtgaaa
2300941 gtgaaaggcc ggtggcggat ttgagccggt tacgcatttc gaccgcggtc aacgagtcaa
2301001 aacccaggtc ctggaacgcc ttgtcggggt cgatggcttc tggcgtgatg ttgcccagca
2301061 cggtggcgat gtgcaaacgc accaggccta gcaagacggc gtgctgttcg gcttcgggca
2301121 gcccgtgcag gcgatgcgcg agcgccgatt tcgactttgc ggcggccacg gagtcgtcga
2301181 cctgacggcg ggtcggcgcg ctggctaggt cggagaacat gggcggcacc gccaccgcat
2301241 gggctcgcag tgcggtgagg tcaatgcggg cgggcgccag gaatggctcg tcgacgatca
2301301 ttgcggtgtc gaacagttcc agcgcctcag cggtggacag cgccagcacc ccttcacgac
2301361 ccagccgggc caggtctgcg gcgtccaggc cgccggtcat ggcgctggcc tgatcccaca
2301421 gaccccagcc cagggagatg gccggcagcc catgggcccg ccggtgggcg gccagcgcat
2301481 ccaaaaacga attggcggcc gcatagttgg cctggcccga cgatccgacc agcccggcca
2301541 tcgacgaaaa catgacaaac gccgacacat ccaggtcgcg agtcaactcg tgcaggtgcc
2301601 acgccgcgtc caccttggac cgcaacacca catccacccg atccggtgtc agtgacatca
2301661 ccaccgcgtc gtcgagtgcg ccggcggtgt ggatcacgcc cgacaatgga tgctgaaccg
2301721 gaatatcggc gatcaccttg gccaacgccg ctcgatccgc cgcgtcacag gccaccacct
2301781 gtacctgcgc accggcggcg gccaactcgg ccaccagctc cgcagccccg ggagcatccg
2301841 ggccgcgccg gctcaccaac accagattgc gcaccccatg acgagccacc acgtgacggg
2301901 ccaccgccga acccgccatc ccggtgccac cggtgatcaa caccgtgccc gccgcccacg
2301961 agccgggcat cagcatgacg accttgccgg tgtggcgcgc ctggctcaga taacgcaacg
2302021 ccgcaggcgc gcgccgcacg tcaaaagtgg tgaccggcaa cggccgcagc accccatcgc
2302081 cgaacagcgt ggcgagctcc agcatgtact gatgcatccg gggacgtccc ggttcgaata
2302141 ggtcgaaggc gcggtagcgc acgcccgggt actgctgggc gatcacgccg gggtcgcgga
2302201 tgtcggtctt gcccatctcc aagaacaccc cacccggtgc caccagacgc agcgacgcat
2302261 ccacgaattc accggccagc gagtccaaca ccacgtcgaa ccctcgaccg ccagtggccg
2302321 cgcggaactt gtcctcgaac tctaggctac gtgaatcgga tatgtggtcg tcgtcaaagc
2302381 ccatggcgcg caaggtgtcc cacttaccct tgctcgcggt cgcgaacacc tccaacccca
2302441 gatgccgagc cagctgcacc gccgccatgc ccaccccgcc ggtgccggca tggatcaaca
2302501 cgcgctggcc cggttgtacg tcggccaaat gtatgaatgc gtagtacgcg gtggtgaaga
2302561 cagccgagat ggcggcggct tcggcgtagg accagtcggc gggcatcggc agcagcagcc
2302621 ggacgtcgcc ggccaccagg gtgccgctgc cgtcggggaa gaatccgaac accgaatcac
2302681 cgaccgagaa ttcggtgaca ccggggccga cctcgacgac cacgcccgcg ccttcgccgc
2302741 cgagcagcgc gtcgtgggtg aacatgccta gggtgatcat gatgtcgcgg aagttcgcgg
2302801 cgatggcgcg catggccacc cggacctggc cgggccccaa cggtgcgtcg gcgttgggaa
2302861 ccggctcgag ccgcagattt tcgaaggtgc ccgcgctgcc cagacccaac cgccatggcc
2302921 catcgcccgg cggcaccaag atggcatccg ccgcgcggct gccgcgcacg cgcgcggtgt
2302981 acacctgtcc gccccgcagc actacctgcg gctcgccagt cgccaacgcc atcgcgatcg
2303041 ccgcgtcgtc ggtggccgca tcggaatcga ccagcacgat ccggcccgga tgctcggtct
2303101 gcgccgaccg caccagcccc cacacggccg cgcccgccag atcggcgacg tcttcgcggg
2303161 gcagcgccat cgcgccccgg gtcgccacca ccagcacccc ggattcatgg tcggtcagcc
2303221 acgactgcac tgcggccaga gcctggtggc tgcgcacgta gctgccggct accggatctt
2303281 ggtcagccgc aaccgattca aagatctggt aggcgggggt aggccccggg gacgtggccg
2303341 ccgacgcggg cgaccagatc acttcgaaca gccggtcggg acccgagccc gacaccgccg
2303401 ccagcagctg ccgctcggtc accgggcggg ccaccatcga ggccaccgac aataccggca
2303461 gacccagccc gtccgccaac tccaccgaca ccgccgacgg ccccgccggc gcgatccggg
2303521 cccgcaccgc cgaggccccc gtggcatgca acgacacgcc ctgccaagcg aacggcaatg
2303581 cgagttcgtc cgggtcgccg gcgatcacga ccgcatgcaa gacggcgtcc aacaaagccg
2303641 gatgcacacc gaacccaccg actcccccgg ccgcctccgg cagcctcacc tcggcgaata
2303701 tttcctcgcc gcgggcccac atcgcggtca gcccgcgaaa cgccggtccg taccggtagc
2303761 cgcgtgtcgc caaccgctca tagccatcgg ccacgtccac cgtcacggca cctgccggtg
2303821 gccacaccga taggtccgcg cctggttcaa ccgacccggg ccgcaggata ccctcggcat
2303881 gcaaaagcca gcccgcttgc gcgtcagctc gggaaaatat cgacacacca cgggaattcg
2303941 aatcccggcc agcgtcgact accacctgca ccgcaacgga gccggtggcg ggcaacagca
2304001 ggggtgcggc cagcgtcagc tcgtcaagca ccgagcagcc gacttcgtcg ccggcgcgga
2304061 tcgccagctc cacgaatccg gtgcccggga acagcaccac gtctgaaacg gcgtggtcgg
2304121 ccaaccacgg ctgcacgttg ggcgacaacc gacccgtcaa caccaccccg ccggaggcgg
2304181 gcaggtcgac caccgcgccc agcaacgggt gttcgctcgc acccaacccc aaaccggata
2304241 cgtcggcgcc tgagccctcg gccgagagcc aaaaccggcg cttgtcaaag gcatacgtcg
2304301 gcagctccac atagcccgct ccgtccagcg tgccccgcca gttcacagcc acccccgcca
2304361 caaacgcgga cgccgccgag agcaggaatc ggtgcagccc accatctcca cgccccagcg
2304421 tggggacgac aatggcctcg ctgtcaccgt cggtgcacgc ggcgaatgtt tcctcgacac
2304481 cggtaatcaa cgccggatgc gggctggatt cgatgaacgt gcggtagccc tgctcgcagg
2304541 cgttgcgcac cgcctggtcg aatagcacgg tctggcggac gttgcggtac cagtagtcgg
2304601 cgtccaaacc agctgtatcc aaacgatttc cggtcaccgt agagaagaag acggtacgcg
2304661 tggatcgcgg ttcgatgccg gacagagctt cggcgagtgg gccacggatc gcctcgacct
2304721 ccaccgaatg cgaggcatag tccacctcga tccggcgggt ccgcagttcc ttggtggagc
2304781 acaccgcgat cagctcctcc agcgcgccca cttcgcccga caccaccacc gccgaggggc
2304841 cgttgacgac ggcgatgctg acccgatcgc cgaagggcgc caacaaatcc cgcgcctggt
2304901 cggcaccgca cgcgatggac accatgccgc ccgggccggc cagtccggcc agcaacttgc
2304961 tgcgcagcgt gaccacccgt gcggcgtcgc gcagcgacag cgcgccggca acgtaggcgg
2305021 cagcgatctc gccttgcgaa tgaccgatca ccgcatccgg atgcactgcg accgacttcc
2305081 acagctcggc cagtgacacc atcaccgcga acagcacggg ctgcaccaca tccacgcgat
2305141 ccagtcccgg tgcaccgggg gcgccacgca gcacgtccac cagcgaccag tcgacaaatt
2305201 ccgcgaacgc ctcggcacac gcgtcgatct gctgcgcgaa tgccggtgcg gtatcgagca
2305261 gttcgattcc catgcccagc cattgggagc cttggccggg gaagacgaac accgtcttac
2305321 ccgccgcagt cgccgtgccc cgaacaaccg agccgcccaa ctggtcaccc gccagctcat
2305381 cgagcccggc caacaaccga tcacggtccc cgccaaccac caccgcccga tgctcaaaaa
2305441 ccgaacgacc cgccaacgac caccccacat cggcaacatc gaggccatca tcgccacgca
2305501 cgtacgcggc caaccgagcc gcctgccccc gcaacgccga ctccgacttc gccgacacca
2305561 cccacggcac caccggcccc gcccaaccag cctcccgccg cggcaccacc ggcaccgcct
2305621 cgataatcac atgcgcatta gtgccactaa tcccaaacga cgacaccccc gcacgacgcg
2305681 tccgagcacc agcaggccac acccgcggcg cggtcaacaa ctccaccgcc cccgccgacc
2305741 aatccacatg cgggctaggc acatccacgt gcaacgtcgc cggcaacagc tcatggcgca
2305801 tcgccaacac catcttgatc accccggcca cccccgccgc ggcctgcgta tgacccatat
2305861 tcgacttcac cgaccccaac cacaaaggtt ctcccggctc cccccgatct tgcccataag
2305921 tggccaacaa cgcctgagcc tcaatcggat cccccaacgt ggtcccggtc ccatgcccct
2305981 ccaccacatc cacctcggcc gcgctcaacc cggcattggc caacgccgcc cgcaccaccc
2306041 gctgctgcga aggaccatta ggcgcggtca acccattcga cgccccatcc tgattaaccg
2306101 ccgacccgac caccaccgcc aacaccggat gacccaaccg ccgcgcatcc gaaagccgct
2306161 gcagcaccaa catcccaccg ccctcggacc agccgacccc atcagcccgc ccggcgtaag
2306221 gcttgcaccg gccgtcgggt gccagcccac gatgcctgct gaattccacg aagaccgtcg
2306281 gtgtggcgtt gacggtgacg ccgccagcca gcgccagatc gcactccccc gaccgcagcg
2306341 atcccaccgc catatgcaac gccaccaacg acgacgaaca cgccgtatcc accgacaccg
2306401 ccggaccctc caaccccagc acataggcca cccgacccga ggcgacgctg gaggtcatcc
2306461 cggtcagccg gtagccctcg atctcctcgg ccaacattcc gtagccgccg acgatgagcc
2306521 cggcgaatac cccggtggcg ctgccgcgca atccggtcgg atcgataccg gcccgctcca
2306581 acgcctccca ggacaactcc agcaacatcc gatgctgtgg atccatcgct aacgcctcgc
2306641 tgggcgaaat accgaagaac gcgggatcga aatccgcgac gccatccacg aagcccccag
2306701 tgcgcgcgta cgacttatgg cgcacgtcgg gatccgggtc gaacaacccg gccagatccc
2306761 acccacggtc ggtgggaaat tctgacatca cgtccctggc gtcggccacc atctgccaca
2306821 gcccttccgg ggaatcgacg ccccccggga agcgacacga catgcccacg atcgcgatcg
2306881 gctcgctcga gcgctccagc aacgcacggt tggtgcgctt caggcgttcc acctggacca
2306941 gcgctttgcg cagcgcttcg gtcgcatgct ggagttgatc aaccattact aacctcgcct
2307001 aactctcgct aatattggcc gtcgccgacc gccggatgcg gctcccgccg agtcaccgaa
2307061 gttgctgcac aaaacgacgc cgtcgtacgg cgctctggcg caagttcgct ggtgagtatt
2307121 gccaactccg gcaggatttc aaagcgtcca atactccctg ggcaccagtg cgcccgtgca
2307181 aagcctgccg tccatggcgc gactgtaccc gcccgcccgt caacgccgga tgggcgcatg
2307241 tcaatgcggt gctagcggtg gtcttcacaa cacagccgca cgaatgcagc gactaggcgc
2307301 cggctcggcg ccacccatcg gcagccctgg cggcccggat cagctcgtcg cacagatcgc
2307361 gcagttcggt cgccgcggct ccttcgtcga gcgcggtgac gacatcctcg gcggcgcatc
2307421 gcacctggta aacacgatcc gacagatcgg ccgcgtcgtc ggctgacaac acgaccgcat
2307481 cggcgggcag cgccctcacc tcaccccggg tcagcatggc gcgctgctcg taagcccgct
2307541 gccggcaaga ctgccggcaa taccggcggc gacggcccat gccgacgtcg gtcacgtcac
2307601 ggccacacca cccgcacggc tgcggacggg cacgacgagt catgcctgca gacattagtc
2307661 cgcccgggtg tccgatcccg gtatcattga tggtcgcgcc gcgcgcgtcg cgtgccggga
2307721 actacgcaga cggccgcagc gtttgccaac cggagccagt cgccagtacg caacctacca
2307781 gcagagccca gggctcacag gacctaaagg agtagcgccc atggctgatc gtgtcctgag
2307841 gggcagtcgc ctcggagccg tgagctatga gaccgaccgc aaccacgacc tggcgccgcg
2307901 ccagatcgcg cggtaccgca ccgacaacgg cgaggagttc gaagtcccgt tcgccgatga
2307961 cgccgagatc cccggcacct ggttgtgccg caacggcatg gaaggcaccc tgatcgaggg
2308021 cgacctgccc gagccgaaga aggttaagcc gccccggacg cactgggaca tgctgctgga
2308081 gcgccgttcc atcgaagaac tcgaagagtt acttaaggag cgcctcgagc tcattcggtc
2308141 acgtcggcgc ggctgacccg ggaaccccct gctcccggcc gggcaatgtc cggtcgtgcg
2308201 cgtgcgtggt ccgagcgcga aaggcgtccc tcgatgcccc agcgggcgac tttgaccagc
2308261 gcctcacgaa tgttggaccc gctcatcttg gacacaccga gctcgcgctc ggtaaaggta
2308321 atcggcacct cggtgacgac gaacccgttg ctcaccgtgc gccaggtgag atcgatctgg
2308381 aagcagtagc ccttggagtc cacgccgtcc aggtcaatcg cttcgagtgc ttcgcggcgg
2308441 tacgcgcggt agccagcggt gatgtcgtgg atcccgattc cgagcgccag gcgcgaatag
2308501 gtgttagcgg ttttggacag gactagccgc cgccaaggcc agtttcgtac cgtccccccc
2308561 gcgacatagc gcgaaccaat cgcaagatcg gcaccagcgt cgacggcgtc cagcaggcgc
2308621 tgcagctgtt cgggcgcgtg gctgccgtcg gcatccatct cgaccagcac cgaatactcc
2308681 cggctcaacc cccaggcgaa acctgccagg tacgccgcgc ccaaaccgtt cttggcggtg
2308741 cggtgcatca cgtgggtgcg gccgggatcg gcctgcgcca gctcgtcggc gagctggccg
2308801 gtgccgtcgg ggctgctgtc gtcgacgacc agcacgtgca cggcggggca tgcttgcgtc
2308861 agccgccggt ggatcaccgg aaggttctcc cgctcgttga acgtaggaat gatcaccagg
2308921 acgcgctggc tgggacggtt acccggggct gggggcgccg gctggccggt ggtcatgtaa
2308981 ctcctcgatg ttgctctgtg tcgtccgaaa ccggatgagt gtcggccgcc ctgctcgggc
2309041 tgaatgagtt cgtcgtcgga ttcactcagg gccggcggac cggaggcctc agatctgccc
2309101 gggggcgcat cggaatcgtc attttcgccc tttggctccg agcgcctcgg acgcgggaac
2309161 cacccattct gccgcatggc gacgagaacg accgctgcgg ctgccccgac gagaatccat
2309221 tgcaggattg gaccccatcg agttgccggt gtcagcctcg tcttgaggcg cacctggctg
2309281 tccaggtatg cgggctggaa aaagtcggtc cggatcagct cacccccgtc tggtgctatc
2309341 accgcactga tcccagtggt accggcaacc accacgtatc tgtcgtgctc gacggcccgt
2309401 accttggcga atgccagctg ctgttcgctc attgtcttgt tgaaggtggc gttgttgctg
2309461 ggcacggtca acagctgcgc gccgcccaga atcgacttcc gcggggcgcg gtcgaagatc
2309521 acctcccagc aggtagccac cccgaccggg accccagcga tgcgcaccac accggtgccg
2309581 ttgccgggca cgaagtggcc ggcgcggtcg gcgtagccgg agaggtgccg aaacagccac
2309641 ggcatgggca ggtactcgcc gaagggctgc acgattgcct tgtcgtggcg gtcggccggc
2309701 ccggtgccgg gattccagac aatggccgta ttggtccact ccggattttc acgaggacgg
2309761 cccggaacat ccatcagggt gccgatcagg atcggcgcgc cgatcgcttc ggccgctgcg
2309821 gagatccgtt gaccggcgtc ggggttgacg aacgggtcga tgtccgacga gttctccggc
2309881 cagatgacga actggggttg ctgcgccagc cccgcatgca cgtcggcggc cagccgcaac
2309941 gtctcctcaa cgtggttgtc tagcaccgcc cgacgttgcg cattgaagtc gagaccgagc
2310001 cggggcacat tgccctggac caccgcgacg gtgaccgtgg gttcgccgcc cgatccgcta
2310061 cccgcatgcc gcacctgcgg ccagacgacg atggcggcga acaagaccag gcatatgcac
2310121 gcggccggca gcaccaccgc cggcggcgca tccccctgac caccggttcg ccaccacttc
2310181 tcgatttcca gcgcgatcgc ggtcaagccg catccgacca gcgctacccc cgttgacagc
2310241 agcgccacac cgccgagctg gaccaacggc aacagcgggc cttcggcttg accgaaggcg
2310301 accgaccccc acggaaatcc accgaacgga aggatcgact tcaaccactc ctgcgccgcc
2310361 caccccaccg cgaaccagat cggccaaccc ggcaacaggc gtaccacgac ggcgaacaga
2310421 ccgaagatgc cggggaacag cgcgcacgtc gtcgccagtg ccaaccaggg cccggggccc
2310481 accagctcgc cgatccacgg caacaacgag acgtagaaca ccaggccgaa tagcaggccg
2310541 tagcccagcc cacccaccgg tgtcgtcgcg cggtgggtca gcacccaggc cagcaatgcg
2310601 agcgcaacca ccgccgccca ccagcagttg cgcggcggga agctggcata caacagcaga
2310661 ccggccacga tgctgaccac caggcgcgtc agccgcgtcc gcaccgcggt ccgtgtggtg
2310721 ggcagctgcg ctgccaccca ggcgccaagc ttcaccaggc gccggcgggc cgcggcgccg
2310781 agccaggcag ccgcgctcgg cgcgtcgggg ccttccgccg gctcggccga cagttcgatc
2310841 tctggatcgg cggggctctc cgggccggcc tcggcgacct cagcgggccg cgccttccgg
2310901 ccgaaccatt ccctagccat agatgaccgc acctcgatgc acggtttggc ggcaacgcgg
2310961 caaggcgtcg gtcgggccca gccgcggcaa tgcgggtacc cgggagcgcg ggtcggtaga
2311021 ccagcgctgg actgcgtcgc gcggtgcgtc gacgtcaaag tccccggcgt cccatatcgc
2311081 gtaggacgcg ggcgcgcccg gcaccagggt gccgatccgg ccgtctcgaa caccaccggc
2311141 ccgccagccg ccgcgggtcg cggcagcaaa cgccgcccgc gccgataccc cgctgcccgg
2311201 cgtgcggtga ttgaccgccg cgcgcacgct ggcccaggga tcaaagcccg tgacgggcgc
2311261 gtcggagcca agcgcgaggg gcacgccttg ggatgctaac agcgccagcg ggttgagttc
2311321 gctgcctcgc tgggcgccca ggcggcgagc gtacatgccg tcgccaccgc cccacagctc
2311381 atcgaagttg ggctgcacac tggcgatgac cccccaagcg cccagcttcg cggcctggtc
2311441 cgcggtgacc atctccacat gctcgaggcg gtggccgcag cgggcgacgg caaccacgcc
2311501 gagatctgcc accacccgtt cgaaggcggc gactgcggcc gacaccgcag cgtcgccgat
2311561 gacgtggaag ccggcggtca cttcggcctt ggtgcatgct cgtacgtgcg cttcgatgcc
2311621 gtctacgtca aggtggcagg tgccgatgca gtcgggggcg tccgcgtagg gctcgtgcag
2311681 ccaggcggtg cgcgacccga gcgccccgtc gacgaacaaa tcaccggcca gccctcgagc
2311741 cccggtctcg gtcaccaggt cacgggcctg ggccggcgtg gccacggcct caccccagta
2311801 cccgatcacc tcgactccgt gctcgagtgc acgcagccgc aaccagtcgt cgagcccgcc
2311861 gatttccgga ccggcgcatt cgtgcacggc gacgacgccg gccgcggcta tggcctgcag
2311921 cgccacggcc cgggcgtcgg caagctggac gtcggtcaag aggtagcgtg cggcggcccg
2311981 ggctaggtgg tgggcatcac cggtcagcgg ccgctgggcc gtgtaaccgg ttgccgccgc
2312041 cagctcgggg accagccgcc gcagtccgga ggagaccaac gcggagtgcg agtcgatcct
2312101 ggccaggtag gcgggacagt caccgagaac cgcgtctagg tcggcggtgc tgggcgcagc
2312161 attctccggc caggccgact catcccaacc gtgaccccac agcggctgac ccggatggtc
2312221 ggccgcatag tcggcgacca tccgtaggca ctgcgcgcgt gaggtcgcgg gccgcaagtc
2312281 cagcccgctg agcatcagac cggtcgcggt caggtggatg tggctgtcca cgaaccccgg
2312341 cgccacgaat cggccgtcga gatcctgcac gtcagcgtct gggaactggt cgcggccgac
2312401 gtcgtcgctg cccaaccagg cgacgacatc gccgcgcacc gccatcgcgg tggcttcggg
2312461 gtgggtgggg ctgtacaccc ggccgttgac caggagtttg acgggaatct ggctcacacc
2312521 gctaattcga ccccggcgat ggaggttctg cggctacccg agggggctga agggtcaacg
2312581 gctcgacatc tatgacgtcg atgacctcgc catcaataaa gtccgggtcg gtgccgctct
2312641 cgccgaaggc cccggccatg ttggccgccg catcggccgt cagtggcacg ttccgcagga
2312701 aaccgcgcac ggcgatcgcg gtcagcccgg gtcgagcgag cgcccggatc ggcggcacca
2312761 gcagcaacag ccccatcgtc gtggtgacca gaccaggaac aagcaccaag accgaggcaa
2312821 cggtgaccag cgcgccgtca ctcagtgcgc ttcgtggttc cgccaagccg gatcgcaacc
2312881 acaggagccg tcggccgagc tgccagccac cgagcggcgc cagcagaccg aacccgagga
2312941 cgaacgtcgc cagcaacacc agcaaagtcc agccaaaccc gatcgtcgcc gccagcgcga
2313001 aaaccaccgc gagctcgacg acggcgtagc tgagcagcag ccgcgacacc acgtgacgcc
2313061 aacgtctgcg ggctaggccc gagttcctcg ggggcggaca tcgaggctgc agttagatga
2313121 cgctatgaca acgatagaga tcgacgctcc cgccggaccc attgatgcgc tgctgggcct
2313181 tccccccggc cagggcccgt ggccgggtgt ggtggtggtg cacgacgcgg tcgggtatgt
2313241 ccccgacaat aagttgattt ccgagcgtat cgcccgggca ggctatgtgg tgctcacccc
2313301 gaacatgtac gcccgaggcg gccgcgcccg atgtatcacc cgagtctttc gcgagctgtt
2313361 aacgaagcgg ggccgcgcgc tcgatgacat cctggccgcc cgcgatcacc tgctggccat
2313421 gccagaatgc tccggtcggg ttggcattgt gggcttttgc atgggcggtc agtttgcgct
2313481 tgtcttgtcg cccagaggtt ttggcgccac cgcgcccttt tacggcactc cactgccgcg
2313541 ccacctcagc gagacgctaa acggggcatg cccgatcgtc gccagcttcg gcacccgcga
2313601 cccgctgggt atcggcgcag ccaatcgact acgtaaagtg accgcggcca aaaacatccc
2313661 cgccgatatc aagtcctacc cgggcgccgg gcacagcttc gcgaacaaac tgcccggtca
2313721 gccgctggtg cgcatcgcgg gattcggcta caacgaggcc gcgaccgaag acgcgtggcg
2313781 tcgggtcttt gagttcttcg gccagcactt gcgcgccggc tcgcctggtg agccttaggt
2313841 acgacttcga ctccccgcgg atgccgatga ccttgtcccg tcggagggcg gcggggctgt
2313901 catgtccgcg tgcaccccga aggcgagatg aacatgattg tcatcatgaa gtagtgggcc
2313961 acagctgcgg gtgtcagctg gcgaaaaatg cgcgcggcgc cctcttcgtt gcctgacgtg
2314021 tgcggcgcgc cgacatgggt ttggcgagca tggcctcggt aagttccccg gcttgccgga
2314081 tgcgggtcat gggcacagtg cagcgcgtcg ctgcctgtcc tggcccgggt agggcagcag
2314141 cgccatctcg cgggcgttct tgatcgcctg ggcgacttgg cgttgctgct ggactgtcag
2314201 gccggtcact ccccgggagc gaatcttgcc tcggtcagag atgaacaccc gcaatgttgc
2314261 ggtgtctttg taatcgacgc tctcgacgcc gaggctatcg agcaggtttt tcttcgcctt
2314321 cgtcgggccc tttcgcgcgg atttggcggc catctaccag ctggccttcc ggacaccggg
2314381 caggtgtccg tcgtgggcca gttggcggac ccgcacacgg gagagcccga atttgcggag
2314441 atgtccgcgc ggccggccgt cgatggcgtc gcggttgcgt aaccgcacgg gactggcgtc
2314501 gcggggctgg cgggcaaggg ctcgctgggc ggtactgcgc tgttcggggg cgctcgatgg
2314561 ggatcggatg atgtctttga gcgcggtgcg acgcgatgcg taacgggcga cggtggccgc
2314621 ccgccgctga ttcttgacga tcttggactt cttggccacg tcagcgttcc tcgcgaaagt
2314681 ccacgtgacg ccgcaggatc gggtcgtatt tgcgcaagat gagacggtcg gggtcattac
2314741 ggcggttctt gcgggtggtg taggtgtagc cggtgcccgc cgtggaacgc agcttcacaa
2314801 tcggccggat gtcggtgcgc gccatcagat ccgctgcccc tggcgacgca ggcgggccac
2314861 gaccgcttcg ataccgtcgc ggtcgatgac ctttataccc ttcgtggaca cccgcagccg
2314921 aatgcgacgg ccctcggagg gcaggtaata cgttcgttgc tgaatgttgg gcgaccatcg
2314981 ccgacggctt cggcgatggg agtgcgagac ggtgtttcca aatcccggct tgcggccggt
2315041 gacttggcag tgggcggaca aggggcaccc ttccttcgaa gctcggctta ttgaaaatca
2315101 ttttcgacaa cagctaggtg gcactgtacc gtcgacgtcg caataatgaa aactgttatc
2315161 gataaggagg acggtggcca ccccggtgat ccttgtcacc ggacacgagg gcaccgccgc
2315221 cgtgaccgct gacctgctgg gcctgctcac cgatcacggc actgcgacac ttcggtcagt
2315281 ggcaccagga tccgtgcggc gagccgatcc ccgcccacgg tgtcaccgcc gagaacaacg
2315341 acgacgacac cgggcatcca tgaaatccgc catccatccc gaccaccacc cccgtcgtct
2315401 tccacggtgc ccggtcctcc gccgcgacca agttgtactg gaaatgattg tcattacgat
2315461 ggtcgggcgg ccgagcgggc cgggcgaaag gaaatgggat gtgtggggca gcgtggcacg
2315521 cgcggtcacc ggcgggcatg tacccgtcaa atccatcctc accggcgccc atgccgaccc
2315581 gcattcgtac caggccagcc ccgcggacgc cgccgcgatc gtcgacgcgg agctggtgat
2315641 ttacaacggc ggcgggtacg acccgtgggt cgaccaggtg ttggccggcc atcctggtgt
2315701 ccaggcggtc gatgcctact cgctgctcgg cgccgtgggc gacgacgacg cgcccaacga
2315761 acacgtcttc tacgacccca atgtcgccaa ggcggtcgcg gcaacgatcg ccgaccggtt
2315821 ggcggacctc gacccgtcca attccgggaa ctatcgagcg aacgccgccg agttcagccg
2315881 cggcgccgac gcaatcgcaa tttccgaaca cgcgatcgcc accacctatc ccgacgccgc
2315941 ggtcatcgcg accgaacccg tcgtgcacta cctgctggcg gcagccggcc tgaaaaatcg
2316001 aaccccggct accttcatcg cggccaacga aaacggcaac gaccccaccc cggccgatat
2316061 ggcggccgtg ctcgacatga tcgccggccg tgaggtcgcg gcgttgctgg ttaacccgca
2316121 gacacctacc gcggcgaccg acgaactgca ggtggccgcc cggcgggcag gagtgccaat
2316181 caccgagttg accgagacct tgcccagcgg aaccgaccgg gaccagtttt gcgctgctga
2316241 ccggccagat cgtcggggtc ggtcactccg ggctgaccat gctgaccgtg gtttgtctgc
2316301 tcgtggtcac cgtgttggcg atctgctacc gaccgctctt gtttgccacc gtcgatccgg
2316361 aggtcgcggc cgcccgcggc gtgccagtgc gcgccctggg aattgtgttc gccgcactga
2316421 tgggcgtggt agccgcccag gctgtccaga tcgtcggggc actcctcgtg atgtctttgc
2316481 tgatcacccc cgccgcggcg gccgcccggg tcgtggttgc cccggtcgcc gcgatcgcga
2316541 cctcggtggt cttcgccgag gtttccgccg tcggcggcat cctgctgtcg ctggcgcctg
2316601 gagtcccggt gtcggtgttc gtggccacca tctcgtttgt gatctacctg atttgctggt
2316661 tgctccggcg gcgccgctaa ctagccggtc tcgctttcgg ccactttgag ctctaggcca
2316721 atgttgttcc gcatgccgcc gcgcagctta ctgacgaagg tgaacagctt gccctggatg
2316781 ccgtagcgct tgacgatcgc gtcgtagacg gcgcccgttt gggattcgtc gaggatggcc
2316841 gcggtggctt cgacggcctc gctggtcggc cggccgcgca aggtgcaggt cgccagcgtc
2316901 acccgcggcg tgttgcggat ccgcttgacc ttccacgatt tcttctcggt gatgaccagc
2316961 agtcgatccc cgcggtcggt gtccaaggcg gcccagatgg gaaccggctt gggccggccg
2317021 tccttggtga aggtggtcag cagcaggtac tgcgcctcgg caaggtcaga aaaggtaggg
2317081 gtcacgggtg ccaacctacc gcgcgagcag acgcagaatc gcactgcgcg gggtcccgcg
2317141 catgcgattc tgcgtctgct cgccgtactc aggcttccag gtcgccctcg gtttccagca
2317201 gcacctggcg caacccgtcc agggtttccg gtgccggctg tgcccacagg ccgcgaccgg
2317261 ccgcttccaa cagccgttcg gccatgccgt gcagcgccca cgggttggac tcggtcatga
2317321 acgtgcggtt ctgcgcgtcc aggacgtaac gctgcgtgag ctgctcgtac atccagtccg
2317381 ccatcacccc ggcggtggcg tcataaccga acagatagtc gacggtggcc gccatctcga
2317441 atgcgccctt gtagccgtgc cggcgcatcg cggccatcca cctcggattg accacgcggg
2317501 cgcgaaacac ccgcgtggtc tcctccgaca gcgtgcgggt gcggatcgcg tcgggtcggg
2317561 tgttgtcgcc gatataggcg gccggtgctt ggcccgtgag cgcccgcacg gtggccacca
2317621 tgccgccgtg atactggaag tagtcgtcgg agtcggcgat gtcgtgttca cgggtgtcgg
2317681 tattcttggc ggccaccgca atacgccggt actggcggtt catgtcgtcg atcgcctcgc
2317741 ggccatccag gtcgcgcccg taggcgaatc cgccccaggc ggtgtacacc tgggcgaggt
2317801 cggcgtcgtc gcgccagctg cggctgtcga tcagctgcag cagcccggcg ccgtaggttc
2317861 ccggtttgga tccgaaaatc cttgtggtgg ctcgccgttg atctccgtgg tgggccagat
2317921 ccgcttgggc gtgcgcgcgc acgtagttgt cctcggcggc ctcgtcgagg tcggcgacca
2317981 accgcaccgc gtcatcgagc atggtcacca catgcgggaa ggcatcacgg aaaaagccgg
2318041 agatccgtac cgtcacgtcg atgcgcgggc ggcccagctc ggccggctgc atgggcgcca
2318101 ggtcgatgac ccgccgcgag gcgtcgtccc ataccggccg aacccccagc agcgcaagca
2318161 cttcggcgat gtcgtcgccg gccgtgcgca tcgccgaggt gccccacacc gacagcccca
2318221 ccgaccgcgg ccaccgccca tgctcatcgc ggtagcgcgc cagcagcgaa tcggccagtg
2318281 ccacaccggc ttcccacgcc agccgggacg gcaccgcctt gggatccacg gagtagaagt
2318341 tgcgcccggt gggtagcacg ttgaccaggc cgcgcagcgg cgaccccgac ggcccggccg
2318401 ggatgaaccg gccgtccaaa gctcttagca cctgctcgat ttcggttgcg gtgccagcca
2318461 accggggtat cacttcggtg gcggcgaacc gcagcaccgc ggcggcgtcg gcgttgccgg
2318521 tgagtcggtc ggcggcggag gggtcccagc cggtggcctg cagggccgcg accagttcgc
2318581 gggctttcgc ctcggtctgg tcgactgtcg cgcgttcgtc ggtgccatcc tcggccaggc
2318641 cgagtgcctg ccgcaggccg gggatcgcgt gcgcgccgcc gaacagctgg cgggcccgca
2318701 agatggccag caccaggtcg agttcttgct cccccgttgg gttttgcccg aggatgtgca
2318761 gcccgtcgcg gatctggacg tccttgatct cgcacagcca gccgtcgacg tgtagcagca
2318821 tgtcgtcgaa cgagtcctct tccgggcgtt cggtcagtcc caggtcgtgg tccatcttgg
2318881 cggcgcggat cagcgtccag atctgctggc ggatggcggg cagcttgccg ggatccagcg
2318941 cggcgacgct ggcatgctcg tcgagcaact gttccaaacg cgcgatgtcg ccgtaggttt
2319001 cggcgcgggc catcggagga atcaaatggt cgactagcac cgcgtgcgcg cgccgcttgg
2319061 cctgggtgcc ctcgccgggg tcgttaacca gaaacgggta gatcagcggc agatcgccca
2319121 gcgcggcgtc gggtccgcag gacgccgaca tgcccagcgt ctttcccggc aaccattcca
2319181 ggttgccgtg cttgcccaaa tgcaccacgg cgtgcgcccc gaaaccgttc gagaatccgg
2319241 tatcgagcca gcggtaggcg gccaggtagt ggtggctggg cggcaggtcc gggtcgtggt
2319301 agatcgccac cgggttctcc ccgaagccgc gcggcggctg aaccatgagc accaggttgc
2319361 ccgctcgcag tgcggcgatg acgatctcgc cgtccgggtc gtggctacgg tcgacgaaca
2319421 gctcaccggg tggcgggccc cagtacgctg ttaccacgtc tgtcagttcg gcgggcaggg
2319481 tggcgaacca gtcccgatac tccttggccg acacccggat ggggttgccg gccagctggc
2319541 cttcggtgag ccagtcgggg tcgtgtccgc cgcattcgat caacgcgtga atcagcgcgt
2319601 cgccgtcgtt tgattcgaca cccggcagat cacccacccg atatccgcgc tgccgcatcg
2319661 cttgcagcaa ggccaccgcg ctggccgggg tgtccaggcc caccgcgttg ccgatgcggg
2319721 cgtgtttggt cgggtaggcc gagaagacca gggccacccg cttgtcggcg ggggcgacct
2319781 ggcgcagccg tgcgtgccgg accgccaggc ccgcgacccg ggcgcagcgc tccgggtcgg
2319841 ccacatagga gatcagcccg tcgtcgtcaa tctccttgaa cgagaacgga accgtgatga
2319901 tgcggccgtc gaactcgggc accgccacct ggctggccac gtccagcggc gacaggccgt
2319961 cgtcgttggc gcaccactga tcccgcgggc tagtcaaaca caggccttgc aggatcggga
2320021 tgtccagcgc cgccaggtgc tcaacgttcc agctgtcatc gtcgccgccg gccgaggcgg
2320081 cggccggctt gactcccccg gcggccagca cggtgaccac catggcgtcg gcgccgccga
2320141 gcctttccag cagccgcggc tcggcggtgc gcagcgacgc gcagtagagc ggcagcgggc
2320201 gtccgccggc gtcttcgatc gcccggcaca gcgcctcgac gtagccggtg ttgccggcca
2320261 ggtgctgggc acggtagtag agcaccgcga tcgtcgggcc ggtcttgccg gcgtccggac
2320321 gctccagcac cccccaggtc ggggtggcga ccggcggcgt gaacccgaag ccggtcatca
2320381 gcacggtgtc gcacaggaag gcgtgcaact cgcgcaggtt gtcgacgccg ccgtgggcca
2320441 ggtagatgtg ggcctgcagc gcggtgccgg ccgcgaccgt ggagcggtcg gtcaactcgg
2320501 catcggcggc ctgctctccg ctgaccagta cggccggtac cccgccggcg atcaccgtgt
2320561 cgattccgct ctgccaggcg cggtagccgc cgagaatccg gatcaccacg atcgacgctt
2320621 cggccagcag gtcggtcagt tccaggtcag acagccgcga gggattcgcc caccggtagt
2320681 tcttgccgct ggaccgggcg ctaatcaggt cggtgtcgga cgtcgacaac agcagaacgg
2320741 tcggttccgg caccaattct tcttaccgga gcaggactcg agcggtggcg tcgggcccgc
2320801 gagctttgta gccacgccta gactacaaac atgtctacat ccacgacgat tagggtttca
2320861 acccagactc gggatcgtct ggccgcccaa gcccgcgaac ggggaatctc gatgtcggct
2320921 ctgctcaccg aactggccgc ccaggccgag cgccaggcaa tcttccgcgc cgaacgcgag
2320981 gcctcgcacg ccgagacgac cacccaggca gtccgcgacg aggaccgcga gtgggagggc
2321041 acggtaggcg acggccttgg ctgagccacg gcgaggagac ctttggctgg tcagcctcgg
2321101 cgccgctcgc gcgggtgagc ccggcaagca tcggcccgcg gtggtcgttt ccgtggacga
2321161 gctactcacc ggaatcgacg acgaactcgt tgtcgtcgtg ccggtgtcaa gctcgcgctc
2321221 ccgcacccca ctccggccac ctgtcgcgcc ctcagaaggt gtagctgccg atagcgtcgc
2321281 ggtgtgccgc ggcgtccgcg cggtcgctcg tgcccgactc gtggagcgac tcggcgccct
2321341 caaacccgcc acgatgcgcg caatcgaaaa cgccctgacc ctgatcctcg gcctcccgac
2321401 gggacctgag cgcggcgagg cggcgaccca ttctcccgta cggtggacgg gtggccggga
2321461 cccgtgacgc ggacgcctgc cccggtgcgt tgcggccgca ccaggccgcc gacggggcgc
2321521 tggcgcggat ccggctgccc ggcgggatga tcaccgcggc acaactggcg acgctggcca
2321581 gcgtcgccag cgacttcggc tccgcgacac tggaactgac cgcgcgcggc aatgtccagt
2321641 tgcgcgggat ccgcgacgtg gcagcggtcg cggacgcggt cgccaaagcc gggctgctgc
2321701 cgtcggcaac acacgagcgg gtgcgcaata tcgtcgcctc gccgctgtcc ggccgggccg
2321761 gcgggctagc cgacgtgcgg gcatgggtcg gtgagctcga cgcggcgatc cgcgccgagc
2321821 cccggctggc ggaactgggc ggccggttct ggttcggtct cgacgacggc cgcgccgacg
2321881 tgtccggcct gggtgccgac gtcggcgtgc aggtgttccc cgacggtccc cgactgctgt
2321941 tgaccggacg tgacaccggc gtgcgggtgg ccgatgtcgc cgagaccctg atcgaggtcg
2322001 cgttgcgttt cgtcaagatc cgcgaaaccg cctggcgagt aacggaatta gccgatatcg
2322061 gcgagctgca gtccggtgtc gagctgggcc catccgttcg gcccgtcacc aaaacgcccg
2322121 tcggctggat accccaggat gacagccggg taacgctggg cgccgcggtg ccgctggggg
2322181 tcttgcccgc ccgggtcgcg gaatgcctgg ccgcgatcga ggccccgctg gtgatcacgc
2322241 cgtggcgatc ggtgctgatc tgcgacctcg acgacgcgac ggccgacgcc gcgctgcggg
2322301 tgctggcgcc gctgggcctg gtgttcgacg agaactcccc ctggctgaac atcagcgcct
2322361 gcaccggcag ccccggctgc gcgcactcgg ccgccgacgt acgggccgac gccgcgcggt
2322421 cactgaacgt ggagtcagcc gggcatcggc atttcgtcgg ctgcgagcgg gcctgcggca
2322481 gcccaccggc cggcgaggtg ctggtcgcca ccggcggtgg ataccggcga ttgcggccgt
2322541 agggtgagcg agtgctcgac tacctacgcg acgccgcgga aatctaccgg cggtcattcg
2322601 cggttatccg cgccgaggcc gatctggcgc gcttccccgc cgacgtcgcg cgggtggtgg
2322661 ttcggttgat tcacacctgc gggcaggtcg acgtcgccga gcatgtggcc tacaccgacg
2322721 acgtcgtcgc gcgggcgggt gccgcgctgg ccgccggtgc cccggtgctg tgcgattcgt
2322781 cgatggtggc cgccgggatc accacctcgc ggctgcccgc cgacaaccag atcgtctcgc
2322841 tggtcgccga tccacgcgcc accgagctgg ccgcccgtcg ccagaccacc cgatcggcgg
2322901 ccggggtcga gctgtgtgcc gagcggctgc ccggcgcggt gctggccata ggcaacgcgc
2322961 ccaccgcgct gtttcggctg ctcgaactgg tcgacgaagg ggcaccccca ccggcggccg
2323021 tgctgggcgg accggtgggt ttcgtcggat cggcacaggc caaagaggag ctcatcgagc
2323081 ggccccgcgg gatgtcctac ctggtggtgc gcggtcgccg cggcggcagc gcgatggccg
2323141 ccgccgccgt caatgcgata gccagcgacc gcgaatgagc gctcggggca cgctgtgggg
2323201 agtcgggctg gggcccggcg atccggagtt ggtgaccgtc aaggccgccc gggtgattgg
2323261 cgaggccgat gtggtggcct atcacagcgc cccacacggt cacagcatcg cccgcggcat
2323321 cgccgaaccg tatctgcggc ccggtcagct cgaggagcac ctggtctacc cggtgaccac
2323381 cgaggccacg aatcatcccg gcggctacgc cggtgcgctc gaagacttct acgccgacgc
2323441 gaccgagcgc atcgccacgc acctggacgc cgggcgcaac gtggcgctgc tcgccgaagg
2323501 cgacccgttg ttctacagct cctacatgca tctgcacacc cggctgacgc ggcggttcaa
2323561 cgccgtcatc gtgcccggtg tgacgtcggt gagcgccgcg tcggcggccg tggccacacc
2323621 gctggtggcc ggcgaccagg tgttgtcggt gctgccgggc acgctgccgg tcggcgagct
2323681 gacccgccgg ctggccgacg ccgacgcggc cgtggtggtc aagctgggcc gttcgtatca
2323741 caatgtgcgg gaggcgcttt cggcgtccgg cctactcggc gacgcgttct acgtggagcg
2323801 ggccagcacc gccggccaac gggtattgcc ggccgccgac gtcgacgaga ccagcgtgcc
2323861 gtacttctcg ctggccatgt tgccgggcgg gcggcgtcgt gcgttgctga ccggcaccgt
2323921 cgcagtggtg ggcctggggc ccggcgacag cgactggatg acaccgcaga gccggcgtga
2323981 gctggccgcc gcgacggatc tgatcggcta tcgcggctac ctggaccggg tcgaagtccg
2324041 cgacggccag cggcgccatc ccagcgacaa caccgacgaa cccgcccggg cgcggctggc
2324101 ctgctcgctg gccgatcagg gccgggcggt ggcggtggtg tcctccggcg acccaggggt
2324161 attcgcgatg gccaccgccg ttttggagga agccgagcag tggccggggg tgcgggtccg
2324221 ggtgattccg gcgatgaccg ccgcccaggc cgtcgccagc cgggtcggcg cgccgctggg
2324281 acatgactac gcggtgatct cgttgtccga ccggctcaaa ccctgggacg tgatcgccgc
2324341 gcgcctgacc gccgcggccg ccgccgacct ggtgctggcc atctacaacc cggcttcggt
2324401 gacccgcacc tggcaggtcg gcgcgatgcg cgagctgctg ctggcccatc gcgaccctgg
2324461 cataccggtg gtgatcggcc gcaacgtctc cggaccggtt tccggaccga atgaggacgt
2324521 tcgggtggtg aagttggccg acctgaaccc cgccgaaatc gacatgcgct gcctattgat
2324581 cgtggggtcc tcgcagaccc ggtggtattc ggtggattcg caggaccggg tgttcacccc
2324641 gcgccgctat cccgaggcgg gcagagctac cgcgacaaag tcgagccgcc acagcgactg
2324701 aaagagcttg cggccgaatt cctcaaggtc ggccaggctg cctccggaag gctcgccagt
2324761 tcgcgccacg cacccggcaa tctcccgaat cgtgcggcga ccgtcaacct gctgcagaaa
2324821 ggccaactgg gcggggctgg gcgccatgcg ccaacccggc caaaacatat cggtgccgga
2324881 gacaccgcaa cgcgtgcgca tcagcggtac gtaatcgagc gcggcaaccg tcgaaaaatc
2324941 gatcgtgtac tgctccttgg gtcggtcacg acggcacgcc ataaagagat gggtagcgtt
2325001 caaggtctcc agacgttcca tcacggacca ggccttgacc tcgggtaacg tgttcacggc
2325061 cgcataaaac tcgctgttcg ggacgaaaaa atcgtgcggg taatacggcg ccttgtggaa
2325121 ccatccctga aataccagtc cggcggacgt gaccagatcg acgcattcct cgacggtgta
2325181 actgcgttgg cgaccatgca agaacgtatc gacgagggcg ctatcggaaa gtaaatcccg
2325241 agctttcgtg agatagtttc ggagcggatg atacgtcggt agtaacgaga ttgcttcctt
2325301 cgccaatttg atcgatgcat cgtcctgccc taatccaaga tcacgaaaga ccgaaccgag
2325361 cagttcgact ccgatccgac cgtacttccc gtagagcatc gccgccacga cgccatcccg
2325421 gcgcaggcag tgggcgagtt ctttcatgcc cgcccgcgga tctgccaggt gatgtaaaac
2325481 gccggtcgat accacgaggt cgaagtcgcg tcccagcgtc gccagctctt cgatcggaag
2325541 cagatgcaac tccagattcg ccagcccgtg cttgtctttc agatattgct gatggtccag
2325601 tgccggtcga ctgatatcga tcgccactac tttcgccgca cgattggtga atgcgaaaat
2325661 cgccgcctgg ttggttccgc aaccggcgat cagaatatcc agatcgggcc ggtattcgcg
2325721 gtccggccat aatatccggt gggagtgcac cgggtcgaac cattcccaat tcgctgtggt
2325781 ccacgcctca agatcggcga tcgggtgcgg gtacaaccac cggtggtact gccgggacac
2325841 aatgtcggcg cgcggatgat cgtcggtcac ttcggtccca cgagcctatg caagcacacc
2325901 ggcaacgcac gtcgccgcct cggcgagcag cgcctcacgg ggctcggcgt catacccgcc
2325961 gccggcacga tcggacatga cggccaccac gtagggcacg ccggtcggtg accacacgac
2326021 cgcgatgtcg tttgctcgtc cgtagtcacc ggtcccggtc ttgtcgatca ccttccaatc
2326081 ggcgggaaag cccgctcgga tccgcttggc tccggtggtg ttgcgcgcca tccaatcggt
2326141 gagcagtgcc cgcttgtcgg gcggcaacgc gttgccgaga acaagctgct gcaacaccag
2326201 ggcgatggcg tgcggtgttg tggtatcccg ttcgtccccg ggcggatcgc ggttcaactc
2326261 cggttcctcg gcgtccaacc ggctcacggt gtcacccaag ctgcggaggt agccggtaaa
2326321 tgccgcggtg ccgcccccgg gaccgccaag atcggccagc aacaggttgg cggcggtgcc
2326381 gtcgctatag cgtatcgccg catcgcaaag ctgcccgatc gtcatcccgg tctgaacgtg
2326441 ttgttgggcc accggggaga tcgaccgaat gtcgtcactg gtgtaggtga tcagtttgtc
2326501 cagatgcgtg agcgggtttt ggtgcagcac cgccgccacg agcggcgcct tgaacgtgga
2326561 gcagaatgcg aaccgctcat cggcgcggta ttcgatcgcg gcggtggtgc cggtggcggg
2326621 cacatacacc ccaagccggg catcgtatct gcgctccagc tcggcgaagc gatccgccag
2326681 atccgctccg gccggcaagg ttgtcgatgc cggacgggcc ccgctcgcat gccgtgcaca
2326741 ccccgtcacg gaaaccagca ttgccatcgc taccagcagt tcgcgacgac cgaatcctct
2326801 gttgcgcatg ccgtagtatc acacgcgcgc agatggcagg cgccaaagcg cattcgacgc
2326861 cgcgctcccc cggctgctcg gcggcgggat ctacgacgac cggtcgtaga ctgaccggac
2326921 ctgccgggct atggtttatg cccatgaccg cgacggcaag cgacgacgag gccgttaccg
2326981 cactcgcctt gtcggcggcc aaggggaacg ggcgggccct tgaggcgttt atcaaagcca
2327041 cccagcaaga cgtgtggcgg ttcgtcgcct atctgtccga cgtgggcagt gcggacgatc
2327101 tcacccaaga gacattccta cgagcgatcg gcgccatccc gcggttttcc gcacgctcca
2327161 gcgcccgaac ttggttgctg gccatcgcgc gccatgtcgt cgccgatcac atccgccacg
2327221 tccgatcccg gccccgcacc acccgcggcg cgcgtcccga acatctcata gacggcgacc
2327281 gccatgcccg cggattcgaa gacctcgtcg aggtaaccac gatgatcgcc gacctaacca
2327341 ccgaccaacg ggaagcgctg ctgctgaccc agctgctcgg gctgtcctat gcggacgccg
2327401 cggcggtgtg cggctgcccg gtgggcacca tccgatcccg tgtcgctcga gcgcgcgatg
2327461 cgctgcttgc cgacgcggag cccgacgacc tcaccggcta ggcagaccgg ccacccacat
2327521 ggcggcccgg tggacagaat cgaccgccgc taccccagcc ggcagcagcg ggcgcgctat
2327581 catgaccacc gaaataccca gcgcagcagc ggcatccagc ttcgctcggg tcatcttgcc
2327641 accgctgttc ttggtgacca atgcgtcgat gcgctgctca cgcagcagtg cgaactcatc
2327701 gtggtaacca tatggcccgc gagatagcac cagtttgtgc cgccgcggca gggcggtgcc
2327761 atcgggcgcg gtaaccacgc ggatcaaaaa ccacgcgtcg ctgttggcga aggccgcaat
2327821 acccgagcgt ccggtggtca ggaacactcg cgaataacct tgttcagcaa caacgtctgc
2327881 agcctcgatg tccgataccg cgatgatggc ggtaccggga tcccacggcg ggcgagccag
2327941 taccaggtac gggagcccga gctcaccgca cacctgcgcg gcgtgcgcgg tgatggttac
2328001 cgcgaagggg tgggtggcgt cgacgacggc atcgatgcgc tcctctcgca gccaaccgcg
2328061 cagcccctcg acaccgccga acccgccgat gcgcaccgga ccgatcggca gggcagggtt
2328121 gggtacccgg ccggccagcg agctgacgat ctcaacgtgt gggtgcaact ctttcgccag
2328181 cgcacggccc tcggcggtgc cgccgagcaa caacacccgg gtcactgtgc ataccgaccg
2328241 tgccgtgcca ccgaatatag gtagctgtcg gtaaagccct cagcggtcag cacgtcgcca
2328301 acaacgatca cggcggtcct ggtgatcttg gcatcgtgca tccgcgcggc gatatcggcc
2328361 aacgtgccgc gtagcgtccg ctgttgcggc caactcgcga aagccaccac cgcaaccggc
2328421 gtttcgggtc ggtaaccacc gtctagcagt cgcggaacga tggcgtcgat ctgggctgcg
2328481 gccaggtgca agaccagagt ggcgcgggat cgggcgagcg cggccaggtc ctcaccgggc
2328541 ggtatgggtg tggacagcgt cgccacccgg gtgagcgtca ccgtctgcgc cacgcccggc
2328601 acggtgagtt cgcgctttag cgccgccgcg gctgcggcaa aagccggtac gcccggcacg
2328661 atttcgtagc cgatgcccag cgcgtcgagt tcgcggcact gttcggccag cgcgctgtac
2328721 agcgacgggt cgccggaatg cagccgggca acgtcgcggc cgtcggcgtc ggcgtcggca
2328781 agtttgcgca cgatttgttc gagggtcagc ggaccggtgt cgacaatcgt cgcgccgggc
2328841 ggacactgcg ccaacaggtc gtcgggcatg atcgaacccg catacaggca caccgggcat
2328901 cgttgcagga gccgttggcc gcggacggtg attaggtcgg cggcgccggg gcccgctccg
2328961 atgaaataga ccgtcatcgc ttggtcaccg accactgggt gaccggcagc tgtgggcgcc
2329021 aaccggtgaa gccgcccagc ggttcgccga gatagtgctg gaatcgtcgt agctcgccac
2329081 cgaggcgcga atatgcatgc gccagagcgg cttccgattc gacggtgaca gcgttggcga
2329141 ccaagttccc gcctgcgggc aggctgtcca ggcaggcctc aagcaggcct ggctgggtta
2329201 caccaccgcc aagaaaaatc accgacggcc gtgcggcgtc gtcgaacgca tcgggcgcgt
2329261 cgccgcgcac gtcgacgctc accccgaagg ccgcggcatt gaacccaatg ttgcggcggc
2329321 gccgttcgtc gcgctcgaac gccaccgcgg tgcagcccgg ccagctccga caccactgga
2329381 ccgcgatggc gcctgagccc gcgccgacgt cccataaccg ctgcccgggc cttggcgcca
2329441 gcgcagccag ggtcagcacg cggatcgggt gtttggtgat ctgcccgtcg tgcgcgaatg
2329501 cctcgtcggg tgcccacgac gtgcgctcgt cgagcaggta gcgcacggcg atcacgttga
2329561 gctcatcgac atcgaggggt gggtcgcagg cccatgcccg ggccgtaccg tcgcggcggc
2329621 gttcggccgg gccgccaagc tgttcgagca cgctgaactt ggagtcaccg cgaccgtgct
2329681 cggtcagcag caccgccagc gcctgcgggg tggaccgatc gccggacagc acgatggccc
2329741 ggccgccgcg gcgcaccgcg gtgtgtggtt gcgcggtgac caggctgatc acctcggtgt
2329801 catacacgtt ccagcccatc cgggcgcacg ccaacgtcac cgcggacacg tgcggcaaca
2329861 cggtcacgtt gtcgtggccg aacagccgga tcagggtgga gccgatacca tgcaacaacg
2329921 ggtcgccgct ggcaaccacg tgtaggtcag ccccatccgg tgacaggcct tgcaccgcgg
2329981 gcagcatcgg cgtcggccac tcccagcgct cggcggtgac ggtatcgtcg agcagggcaa
2330041 gttgccgttt cgagccgtaa attactgtgg ccctgcgcaa ttcggagcga gaatgctcgg
2330101 agagaccggt catgccgtcg gcgccgatcc cgacaacgat gatcatcggc gccgctctcc
2330161 cccgcaagcg ggcggtaccc ccaccgcatc gctgcgctct gcatcgtcgc ggatcatcgc
2330221 ggcatcctgc gccagacgaa ccggggaagc aaccgcagcg caacaaacat tggccgcagc
2330281 gcccacggaa tccacaccac gcgcttaccg ttgaccagcg cacgcgcggt cgcggcggcc
2330341 acccgctccg gggtgaccga caggggtgcg ggcgtcatgc cctcggtcat gcgcccgatg
2330401 acgaatcccg gccgcgcgat cagtaaccgc accccggtgc cgtgcaacgc atcggccagg
2330461 ccgctggcga agccgtccag gccggctttg gccgatccgt agacatagtt ggcgcggcgc
2330521 acccgaatcc cggcgaccga ggagaacacc accagcgatc cccgtccggc ggtgcgcatc
2330581 gccgctgcca gatgagtcag caggctgacc tgggcgacgt agtcggtgtg cacgatggcc
2330641 accgcgtgcg ccgcgtctgt ctcggcgcgg gcctggtcgc cgagtatccc gaaggccagc
2330701 accgcggtgc cgatggggcc gtgctcggca acgagcgaag cgaccaacgg gccgtgtgcg
2330761 gccaggtcgt cggcgtcgaa ctcccgggtg tgcaccgcta tagcgccagc tgcgcggagt
2330821 gcggcggcct ggtcggcgag ttgatcggcg ttccgcgcgg ccagcaccat cgtcgccccg
2330881 gcagccaggc gtcgcgcgag ttcgccgccg atctggctgc ggccgccgaa aattactacc
2330941 ggagcagcgc ccgtgtcgtc cacggctgcg attattgcct gcgctagcgt gagtggcgat
2331001 ggtcaacacc actacgcggc ttagtgacga cgcgctggcg tttctttccg aacgccatct
2331061 ggccatgctg accacgctgc gggcggacaa ctcgccgcac gtggtggcgg taggtttcac
2331121 cttcgacccc aagactcaca tcgcgcgggt catcaccacc ggcggctccc aaaaggccgt
2331181 caatgccgac cgcagtgggc ttgccgtgct cagccaggtc gacggcgcgc gctggctctc
2331241 actggagggt agggcggcgg tgaacagcga catcgacgcc gtgcgcgacg ccgagctgcg
2331301 ctacgcgcag cgctatcgca ccccgcgtcc caatccacgc cgagtggtca tcgaggtcca
2331361 gattgagcgc gtgctgggat ccgcggatct gctcgaccgg gcctgacaac cgaggtcatg
2331421 gcggcagtag gtaatgcacc caggcgccac cggcgggccc ggccacggcg tgcagacggg
2331481 cgttctgatt gcccgttcgg ggcagggtaa agtccgcgcc gatggctgtg caggctaggg
2331541 cagccccggc gaagaccacg ggtgccggcg tcacggtcca cctgcctgcc gcgtcccgac
2331601 aggccgcagg gtgtgggtca ccgcacgatg cggcgaccca gcggccatcc gcgccctgca
2331661 gggcgcatgc tccggcaccg gcacgcggtt cgtccggtgc ccagctccac aacgacgcct
2331721 gaatgcggcc gtcttcgggg agcagctgat cgaagccgaa cagattgacc ccgcaatcgg
2331781 tcatcgccgg caccttcggc ggggtaagcg cctgcggatt ggccggtgga cgggtcgggt
2331841 tggccaacgc cgtggccagc gtggagtcct cgtaatagcg gaccagtcgc caagcgtaga
2331901 caccgcggcc ataggtggca tcgcaggccg ggtatggccg gtagccggag ttcgagccgc
2331961 tttccagctc aacgccgctc cagtcgaaga cggcggccga ccaacctggc gcacaagacc
2332021 cgacgagcac ggctcgtgcg ccggatgcgc ggatttcctc ccgcgacacg tcgagtggaa
2332081 gcgggacaca gccgttggtg gcacgccggg ccgggttggg acggtagata aggcttgttc
2332141 cgtccgcacg ccgcaacact tggtcgaggg tagccaccac cgactcatac gccgacgcgt
2332201 tcttcagctg gtcctccagg tagagcagga tgacctcctc ggtatgcccg ggtgcgttca
2332261 accagttggc gatctgcggc agcactgtgg ccagcagagg ttcgacggtg cagcctaggt
2332321 tcgcgttctt cggtcccagc ccgtgacaca cggtgacgcc gggggcgccg tggccctcga
2332381 ggcggggcaa gtagtgcagg tctagctcga gcgcgcggac gtcgatgtcg agctgttggg
2332441 ccaacgacag ctgctggttt gagtctgcgt gcgagaccgt gaacgaatcg ctgaggctgt
2332501 tgaacgagtt gtgcgtgccg agccactgag tttcccgcag cggcaccggg tcttgcaacg
2332561 catcctggaa ccgcgcggtg cgatgcaccc aagactgtag gtaggcatca cgcgcggcct
2332621 gggtcacccg gtgcgcgagc ggaagcacgc accgcgcatc gggcacaccg acgcggcgac
2332681 actccgcagc gaccgcgtcg gcgaacttgc cgagcgccac gcaggggatc gcaaccgggc
2332741 ttattacgtc acaggatgcg gtgggcgagg gcggagcggg cacctggtag gcatcggcgg
2332801 ccaccggtgc cgcggttatc aacaccacgg ccaaggcgcc catgagggcc gcgctctgca
2332861 gccatcgggc gcggggcatg cgctactttg gcacgtcgat acaccgctta ccaggggtgt
2332921 tgtcgaagtg ttgcgtggtc tcgtcgaagc cgtcacgtaa ctccaagccg ccccgcgtcg
2332981 atgacgagac actagggctg cgaccgccag ggccgtgtag acgttgctct acaaggtcac
2333041 cggtcctggt cagaacttat ccgacggctc ctgcgcattt tcccgtacac aaccgcgggg
2333101 atgaggacca gcaacccgag actccagata tcccaccaca gtgacccctt cacggcattg
2333161 gcgattgcac tgatggccag cagaacccag gcgacaccca taaaggcgaa atagcacccg
2333221 cccctgagcc gtcccgctgg ccgaggccac agggagcctg cgacaccgcc gatgaggcag
2333281 acaaccacga cggcaacgct gaagacgaca acgggagtcg cgctacttgg tggcacagtt
2333341 gaccaccgcc gctcccgatc cgccaacccc cagtaaggcg gcgccaagta gtgcccagtc
2333401 ggcagggccg gccggaattg ctagggcggt cccaactacg ccagccgatg atcctgcgaa
2333461 acccgcaaca gccgccgtcc actccgcgct gttacatggc cggtgcagag cttgaaacgc
2333521 cagccggcgc gcctccaccg cgatggggtc atccggcggc ctagcggcca gctcgttgac
2333581 catgttgtcc acccaccgtt tggtcgcgtc tgatacgggt gcctctgtcc cggccggtgg
2333641 cagcatcatt gaagtgatcg gatcggagta cggtccgtcg gctccaccgg acgggtgtgg
2333701 cgctcctggc ggtggaggtg ttgggccgtc ttgtttgaag aagtcgacta gctgaaccgc
2333761 gctgtgggca acaaccgggg cgcccgcgaa gcggacattt cccacatcac cggtggtcgc
2333821 ggcgagctga ccggacacct cgttctccgc cgcaaccagt tgcccgacac gtaagcggat
2333881 gtcaccggcc aacgcctgag cctgagctag tcgagcggcc tgcactgcag ccggctgcgt
2333941 cgttttggtg tcggtgaccg ataggtcttc accgacgttg aaaccggcgt cctgggcgtc
2334001 ctctacagca tacataactc ttcgttgtgc cgcgtcgata gtgccggcgc cgttgcgcgc
2334061 gatcgtggct gctctccgca gctggtcggc tatgccactg accgttgaga agtcagctcg
2334121 ggttcgttgt cgcagcccgt cgcccccggc gccattccag gcgatggcat gggcctggtt
2334181 tcgcatctgc agaaacacgt cttcccaccg atccgcggtt tcggtccagt agccggccgc
2334241 atcgataagg tgctcggtgc tccatgcccg gatttgggac agggtggcca gcatctaaac
2334301 caccgtcacc tgcgtcaccg cggccatctc gctcgccgca gttgcctctt gatgggcgta
2334361 agctgcggcc gcggcagcca ccccggtagc cgtagcctgc gtccgggtgg cgaattccgc
2334421 tgccgcgcag cagattgctg cgttgatacc acttaccgcc accgtcgtgg cttggaatgg
2334481 ttggccggat tctggcggcg ttgccgaggc ggcgaactgg gcgccaaggc cctgcgattg
2334541 actggccgca acctcaagct gaccaagtac aacctgtagt tcattcgacc ccacccgcgg
2334601 gagtctaaat cgagaccacg cagagggcta ttcacgccga ttcaaagccg tcgaagaaac
2334661 gacaccaccc gcgggccgat gagacaggaa cgatcacaca ggtgcttgcg aagatccgtc
2334721 accacgtatg cgggcgaacg gtgtgttcgg cctgttggcg gccgccgcgt gcggtgttcc
2334781 catccccgtt atcgacaacc gcgccgagga gatgacgggc cggcacgcca caacggcaac
2334841 gagtttcagc atcacggacc agtcgtgcgc atcatgagga ctgccgcgcc gctgcgctca
2334901 ccgcggtcgt caaagcattg gatccaatga cgccatcgcg gtggcgcccg gtgaggtgcg
2334961 tgaccgtggt ctccggttat accttcgagc cgaccgcagg gtgacttgat cgtcaaatcc
2335021 acgacagtag ccttacacca agtccgaagg gagtagcggt gtttgtcgat gttgaacttt
2335081 tgcattcggg ggcaaacgag tctcactacg ccggtgagca cgcccacggt ggtgctgatc
2335141 agctgtcgcg gggacccctg ctgtcgggga tgttcggtac atttcctgtc gcccagactt
2335201 ttcacgacgc ggtcggcgcg gcccacgcac agcagatgcg aaacctgcac gctcaccggc
2335261 aggcgttgat cacggtgggc gagaaagcgc gccatgccgc gacggggttc accgacatgg
2335321 acgacggcaa cgccgctgag ttgaaagctg tggtatgcag ctgcgccaca taaacatccg
2335381 ggcgctgatc gccgaggccg gcggcgatcc ctgggcgatc gagcacagcc tgcacgcggg
2335441 tcggccggcc cagattgccg agctggcgga ggcgtttcac gcggcgggtc gatacaccgc
2335501 cgaggccaac gcggccttcg aggaagcccg tcgccgcttc gaagcgtcct ggaatcgaga
2335561 aaacggcgag cacccgatca acgactccgc cgaagtgcag cgcgtgaccg cggcgctggg
2335621 tgtgcagtct ttgcaattgc ccaagatcgg tgtcgatttg gagaacattg cggccgacct
2335681 cgccgaggcg caacgggctg cggccgggcg gattgcgacg ctcgaaagtc aactgcagcg
2335741 gatcgacgat cagcttgacc aagcgctgga actcgagcac gacccccgac tggccgcggc
2335801 cgaaagatcc gaacttgatg cgctgatcac ctgccttgag caagatgcca tcgacgacac
2335861 ggcgtcagca ctgggccagc tgcaatcgat acgcgccgga tactcggatc acctgcagca
2335921 atcgctggcc atgttgcgtg ccgatggcta cgacggggcg gggctgcagg gattggacgc
2335981 accgcaatcg ccggtgaaac ccgaagagcc gattcagatt ccgccaccag gcaccggggc
2336041 accagaggtg catcggtggt ggacgtcgct gacgtctgag gaacggcagc gtctgatcgc
2336101 cgagcacccg gaacagatcg gcaatctcaa cggcgttccg gtcagcgcgc gcagcgatgc
2336161 caacatcgcg gtgatgacgc gggacctgaa tcgggtacgt gacatcgcca ctcggtaccg
2336221 cacgtcggtt gacgacgtcc tgggtgatcc ggcgaaatac ggtctgtccg ccggcgatat
2336281 cacccgctac cgcaacgccg atgagaccaa gaaaggcctc gaccataacg cccgtaatga
2336341 tccccggaac ccctccccgg tatacctgtt cgcctacgat ccaatggcat tcggcggtaa
2336401 gggacgagcc gcgatcgcta tcggcaaccc cgacaccgca aaacacaccg ccgtgattgt
2336461 gcccggcacc agcagcagcg tgaaaggcgg ctggttgcat gacaatcacg acgacgcgct
2336521 gaacctcttt aaccaggcca aggccgccga cccgaataat ccgaccgcgg tgatcgcctg
2336581 gatgggatat gacgccccga acgacttcac cgacccgcgt atcgccactc cgatgctggc
2336641 ccgaatcggt ggtgcggcac tggccgagga cgtcaacggt ttgtgggtaa cgcatctcgg
2336701 cgtcggccag aatgtcaccg tgttgggcca ctcgtacggc tcgaccaccg tggccgacgc
2336761 gttcgccttg ggcggcatgc atgccaacga tgcggtgcta ctgggctgcc cgggaaccga
2336821 cctggcccac agcgccgcga gctttcacct ggacggaggc cgggtgtatg tgggtgcggc
2336881 ctctacggat ccgatcagca tgctcgggca gctcgacagc ctcagccagt atgtgaaccg
2336941 tggcaacctt gcgggtcagc tgcaaggttt agccgtcggc ctgggcaccg accccgccgg
2337001 cgacggattc ggttcggtga ggtttcgcgc tgaggtgccc aactctgatg gcatcaaccc
2337061 ccacgaccac tcctattact accaccgggg cagcgaggcg ttgcgcagca tggccgacat
2337121 cgcctccggt cacggcgacg cgctagcatc cgatggcatg ctggcccaac cacgtcacca
2337181 acccggcgtc gagatcgaca ttccaggtct tgggtcggtg gaaattgaca taccgggcac
2337241 gccggccagc attgacccag agtggagccg ccctccggga tctatcaccg acgaccatgt
2337301 tttcgatgcc ccactccacc gctgatcgac ggcttcggct gacgcggcag gctttgctcg
2337361 ccgcggccgt ggtgccgttg ctagcaggat gtgcgctggt gatgcacaaa ccccattccg
2337421 cgggttcgtc taatccctgg gatgattccg cgcacccgct caccgacgat caggccatgg
2337481 cccaagtcgt cgagccagcc aaacagatcg tcgccgccgc cgacctgcag gctgtcagag
2337541 cgggattctc gttcacctcg tgtaacgacc aaggcgatcc gccttatcag ggcaccgtca
2337601 ggatggcctt tctgttgcag ggcgatcacg acgcgtactt tcagcacgtc cgtgccgcca
2337661 tgctgtcgca cggctggatc gacggccccc caccgggaca gtacttccac ggcataaccc
2337721 tgcacaagaa cggagtgacc gcgaacatga gcttagcgtt ggaccacagt tacggagaga
2337781 tgatccttga tggtgagtgc cgcaatacga ccgaccacca ccatgacgac gagaccacca
2337841 acatcaccaa ccaactcgtt cagccatgaa ggcgtcgggt gccttcactg ttcccacatc
2337901 gatgtcagtg atcaccaacc cgtgtggcac gtggcgaccg gcgaccggcg agcccgcatc
2337961 gcaccaggta tcgaggaact cggacccacc ctggtcgaaa cggtacgccg ccgcgacgca
2338021 ctgccccgca tcgcccaagc cgtagtagtg gccgccaccc gcaactacgg cgtccccgac
2338081 aacgaaaccg acctactgcg gtcgcccagg ccaaggtggc caccaaacgc tgctggcatg
2338141 caggtggagt gcacagacac ggcagctgca atagccttac gcgggtgacc aacacccccc
2338201 ccacccacca caggacaatg gacaccaacc caccccccag cgccgccgcg ttcacgcaat
2338261 tggccgttgg cggcggtggc cagcgtcgcg attgccgcgg ttgtgctggg tgccgcagct
2338321 ttaatcgtgg cactgacgcg cccgacgaac agcggtccag ccaccgccgc tggaacgacc
2338381 gccgagccga catacaccgc agcagaaacc gccgccgcgc accaaaagtt atgcgaggtg
2338441 tacaaactgg cagcgcgggc ggtccaaatc gcgacaaacg gcgacaaccc ggcgttcgca
2338501 aacattgcca cagtcaatgg tgcggtgatg cttcagcaga cactgaatac gaccccggcg
2338561 ctcgtgcccg gcgagcgcac cgatgcactt gcactagcag aagcatatgg ccaagctaca
2338621 gcctttgcga tggagcaaga ccatccagcg tggcagtcag cagccaatga tgtcaatgcc
2338681 aaggatgcgc gcatgaaggc catctgcggt ggcgggtgat ctgccacccg gtcggtggtc
2338741 ggcgctcttg gtgggtgcgt ggtggccggc gcggcccgat gcgccgatgg ccggggtgac
2338801 gtattggcgt aaggcggccc agctcaagcg caacgaggcc aacgacctgc gcaacgagcg
2338861 atccctgtta gcggtaaacc aagggcgcac cgccgacgat ttgttggagc gatattggcg
2338921 cggcgaacag cgactagcca ccatcgcgca tcagtgcgag gtcaaaagcg accaaagcga
2338981 gcaagtcgcg gatgcggtga actatttgcg ggatcggctg accgagatcg cacaatccgg
2339041 caatcagcaa atcaaccaaa tcctggccgg caaagggccg atagaggcca aagttgccgc
2339101 ggtgaacgcc gtcatcgagc agtcgaatgc catggccgac catgtgggag caaccgcgat
2339161 gtccaacatt atcgacgcga cgcaacgagt gttcgacgag accatcggtg gtgacgccca
2339221 cacctggttg cgtgaccacg gtgtaagcct cgacactccc gcgcggccac gcccagtgac
2339281 cgctgaagac atgacttcta tgacggcgaa ctcgcctgca ggatccccat tcggtgctgc
2339341 tccgtctgcg cccagtcatt cgacgacaac cagcggcccg ccgacagctc caacaccaac
2339401 atcaccattc ggcactgctc ccatggtgct aagttcatct tcaacaagta gcggcccgcc
2339461 gacagctcca acaccaacat caccattcgg cactgctccc atgccgcccg gcccaccccc
2339521 accgggtacc gtctcaccac ccctaccccc cagcgccccc gccgttggtg ttggtggccc
2339581 gtcagtaccg gccgctggca tgccaccagc agcggcggcg gcaacagcgc cgttatcccc
2339641 acagtcgttg ggccagtcgt tcaccaccgg gatgacgacg ggcacgccgg ccgcggccgg
2339701 tgcacaggcg ctgtcggcag gggcgctgca cgcggcaacc gaacccctgc cgccaccggc
2339761 gccacccccg acgacaccca cggtcaccac accgacagtc gcgaccgcca ccacggccgg
2339821 gattccccac atccccgaca gcgcgccgac ccccagcccg gcaccgatcg cgccaccaac
2339881 caccgacaac gccagcgcca tgacacccat cgcgcccatg gtcgctaatg gcccgccagc
2339941 atccccggcc cccccggccg ccgcccccgc ggggccactg cccgcctacg gcgccgacct
2340001 gcgcccaccg gtaaccacac cccctgccac gccacccacc ccaaccggac ccatctccgg
2340061 tgccgcggtc acaccctcct cacccgcagc aggcggctca ctaatgtcac ccgtcgtcaa
2340121 caaatccacc gcaccagcca ccacccaggc ccaacccagc aacccaacac caccgctagc
2340181 cagcgccacc gcggccgcca ccaccggcgc cgcagccgga gacacctccc gccgagccgc
2340241 cgaacaacaa cgcctacgcc gcatcctcga caccgtcgcc cgccaagaac ccggattatc
2340301 gtgggctgcc gggctacgcg acaacggcca aaccaccctg ctggtcaccg acctcgccag
2340361 cggctggatc cccccacaca ttcgcctacc cgcccacatc accctgctcg aaccggcccc
2340421 ccgacgccgc cacgccaccg tcaccgacct actgggcacc accaccgtag ccgcggcaca
2340481 ccacccccac ggctacctca gccaacccga ccccgacaca cccgcactca ccggcgaccg
2340541 cacagcacgc atcgcaccca caatcgacga actcggaccc accctggtcg aaacggtacg
2340601 ccgccacgac acactgcccc ccatcgccca agccgtagta gtggccgcca cccgcaacta
2340661 cggcgtcccc gacaacgaaa ccgacctcct acaccacaaa accaccgaga tccaccaagc
2340721 cgtactgacc acctacccca accacgacat cgccacggtg gtcgattgga tgctgttggc
2340781 ggcgatcaac gcactgatcg caggcgacca gtcgggggcg aactatcacc ttgcctgggc
2340841 gatcgccgcg atatcaacga ggagatccag atgacgtcaa tcgaatcgca tcccgaacaa
2340901 tattgggcgg cggccggcag gccagggccg gtgccgctgg cgctgggacc cgttcatccc
2340961 ggtggaccga cgctgatcga cctgctgatg gcgctgtttg gcttgtccac gaacgccgat
2341021 ctgggaggcg cgaacgccga catcgaggga gatgacaccg atcggcgggc acatgcggcc
2341081 gatgccgcgc gcaagttctc ggcgaacgag gccaatgcgg cggagcagat gcagggggtg
2341141 ggcgcgcagg gaatggcgca gatggcgtca ggcatcggcg gagcgctcag cggcgcgctc
2341201 ggcggcgtca tggggccgct gacccagctc ccgcaacagg cgatgcaagc cgggcagggc
2341261 gccatgcagc cgctgatgag tgcaatgcaa caggcccaag gcgctgacgg actggcggcc
2341321 gtggacgggg cgcggctgct ggacagcatc gggggcgagc ccggtcttgg cagcggtgca
2341381 ggtggcggtg acgtcggggg cgggggcgct ggcggcacta cccccaccgg ctatctgggt
2341441 ccaccacccg taccgacgtc gtcaccgccg acgactcccg cgggggcacc gaccaagtcg
2341501 gcgacgatgc ccccgcccgg cggcgcttca cctgcctcag cgcacatggg tgcggccggg
2341561 atgccgatgg tgccgccggg cgcgatgggc gcccggggcg aagggagcgg ccaagaaaag
2341621 ccggtcgaaa agcgcctgac cgcgcctgcg gtccccaatg gccagccggt caagggccgc
2341681 ctgacggtgc ccccgagcgc accgaccacg aaacccaccg acggcaagcc cgtagttcgc
2341741 aggcgcatcc tgctgcccga gcacaaggac ttcggacgca tagctcccga cgagaagacc
2341801 gatgccggtg agtgacgatt cgtcgtcggc gttcgatctg atttgcgccg agatcgaacg
2341861 ccagttgcgc ggcggcgagc tgctcatgga tgccgcagca gcatccgaat tactactcac
2341921 cgtgcggtat cagctcgata cccagccgcg gccacttgtc atcgtgcatg gaccgctgtt
2341981 tcaggccgtc aaagcggccc gcgcacaggt gtacggacgc ctgatacagc tgcgacacgc
2342041 gcgctgtgag gtgctcgatg agcgatggca gctacggccg acgggtcagc gcgatgtgcg
2342101 cgcactgctg atcgatgtgc tgaacgtgtt gttggcggcc attaccgccg caggcgtgga
2342161 acgggcatac gcgtgcgcgg agcggcgggc gatggccgcc gcggttgtcg ccaagaatta
2342221 ccgggacgcg ttgggtgtcg agctgcagtg caattccgta tgccgagccg ccgccgaggc
2342281 gatccacgcg ctggcgcacc gcacaggggc taccgaggat gccgactgcc tcccgccggt
2342341 tgatgtgata cacgccgacg ttactcgccg catgcatggc gaggtggcga ccgacgttgt
2342401 cgcggccggc gaactggtga tagcggcgcg acacttgctg gaccccatgc ccaggggcga
2342461 gctcagttac ggcccactcc acgagggggg aaatgcggcc cgtaaatcgg tctatcgacg
2342521 cctggttcag ctatggcaag cgcgccgggc tgttaccgac ggtgacgtcg acctgcgcga
2342581 cgctcgcacg ctgctgaccg atctggacag cattttgcgt gagatgcgca cggccgcaac
2342641 cattcaacag agcggaacgg cgggcgatgg cggcggcggt cgtcgccaag attcgcggcg
2342701 acgcaatggg cctcgacgcc cagcgcgacg cggtacatcg cgcggccgcc gatgcgctcc
2342761 acgcgttgca atcggttggc atacaccaat aggcgaccct ttggcagttg agggtgtaga
2342821 ggagatcggc gcgtcgttgc cggggcggga gtcgacgcct tccgatgatg gaggttccct
2342881 acacccatca ggaagacctc gacgcgtcca tcgccgccgg tggtgcgggc ttggcctgtg
2342941 ctgacacatg accgctttcc gccgccttga ttgttgaccg gcactgggtt tgggggcggc
2343001 cgcgtcactg taggtgagta tgggacgtga gcgacatgtg cgacgtggtg tcgttcgttg
2343061 gcgccgccga gcgtgttctg agggcgagat ttcggccgag cccggaatct ggccccccag
2343121 ttcacgctcg gcggtgcggt tggtctctgg ggatcagcgc ggagacgctg cgccggtggg
2343181 caggtcaagc cgaggtcgat agcggtgtgg tggccggcgt gtccgccagc agaagtggga
2343241 gcgtaaagac cagcgagctt gagcaaacca tcgaaatact caaggtcgca acgagtttct
2343301 tcgcgcggaa gtgcgacccg cgacaccgct gatctgtgcg ttcggcgaca agcacaagca
2343361 cacctacggg gtcacaccga tctgtcgggc actggccgtg cacggcgtgc agatcgcctc
2343421 gcgcacctat ttcgcggatc gcgcggcagc gccttcgaaa cgcgcactgt gggacaccac
2343481 aatcaccgaa atcctggccg gctactacga acccgacgcc gagggcaaac gcccaccgga
2343541 atgcctgtac ggcagcctga agatgtgggc gcacctgcag cgccagggct tccggtggcc
2343601 ctctgccacg gtgaagacga tcatgcgggc caacggttgg cgcggagtgc ccctcgcagc
2343661 gcacatcaca caccaccgaa ccagacccgg ccgcggccca ggccctagac ctggcgggtc
2343721 ggcaatggcg ggctttagca acgaacctgc tggaagcggc cgacttcacc tacgcgccga
2343781 tgacgtggag ttccggctac accgcgttcg tggtcgacgc ctacgccggt gtgatcgcgg
2343841 gctgggaatg ctcgctgacc aaagacgcag cgttcgtcga acgcgcatta cgccacggcc
2343901 ttccagactc acctaggtca cccgtttggc ggagctattc atcatcgcga cgccggaagt
2343961 cagtatactg caatatattt cggcaagaca ccgatgctag ccgggctgcg gccgtcgata
2344021 ggcattgttg gcgacgccct cgacaacgcc ttatgtgaaa ccacgacagg gccccacagg
2344081 accgaatgca gccacggcag cccgtttcgt agcgggccga tccgcaccct ggctgacctg
2344141 gaagacatcg cctcggcgtg ggtggagcac acctgtcaca cacaacaagg tgtgcgaata
2344201 cccgggaggc ttcaacctgc gtagtgggcg gaagcgtttc acgacgcgat cggcttagcg
2344261 tatgcgcggg ccgataccac gggtgcacgc gatcacctgg aactggtgag ttggctatcg
2344321 tggtttggtg attacttgcg cttgggggct tgccgacggt tgcgccgggc gcaagtgggg
2344381 tgcggttttg cggttgatgg atggtagctg gtggcccacg agttgagtgc gggttcggtt
2344441 tttgccgggt accggataga gcggatgcta ggtgccggcg gaatgggcac cgtatatctg
2344501 gcgcgtaatc ccgatctgcc gcgtagcgaa gccttgaaag tccttgctgc ggagttgtcg
2344561 cgtgacctcg attttcgggc acggtttgtc cgcgaagccg atgtggccgc ggggttggat
2344621 catcccaaca tcgtggcggt tcatcagcgc ggccagttcg agggtcggct atggattgcg
2344681 atgcagttcg tcgatggcgg gaacgctgag gatgcgctgc gggcggcgac catgaccaca
2344741 gcgcgggcgg tgtacgtgat cggcgaggtc gccaaggcgc tcgactatgc gcaccaacaa
2344801 ggcgtgatac atcgcgatat caagccggcg aacttcttgt tgtcgcgagc cgctggcggc
2344861 gatgaacgag tgctgctaag cgattttggg atcgcgcgtg cgctcggcga cacgggactg
2344921 acgtccaccg gttcggtgct ggccacgttg gcctatgctg cgccggaagt tcttgcaggg
2344981 caaggttttg atggccgggc cgatttgtat tcgttggggt gtgccctatt tcggctccta
2345041 accggtgagg cgccgtttgc cgccggtgct ggagcggcgg tggcagtggt ggcgggtcat
2345101 ctgcaccaac cgccgccgac ggtcagcgat cgcgtgccag ggctgtcggc ggcgatggat
2345161 gcggtgatcg ccactgcgat ggccaaggat cccatgcgtc ggttcacctc agcgggtgaa
2345221 ttcgcacatg ccgccgccgc agccctgtac gggggagcca ccgacggatg ggtgccgccg
2345281 agccccgcgc cgcacgtcat atcgcaaggc gccgtgccag gttcgccgtg gtggcagcat
2345341 ccggtcgggt cagtgaccgc gttggccacg ccgcccggtc acggttggcc gccaggcctg
2345401 ccgccgctgc cgagacgacc gcgccgctac cgtcggggcg tggcggcggt ggcggccgtg
2345461 atggtggtgg ccgccgcggc cgtcaccgcg gtgaccatga catcgcacca accgcggacc
2345521 gcgacgccgc caagcgctgc agccctttct cccacctcgt ccagcacaac accaccgcaa
2345581 ccaccgatcg tgacaaggtc gcgcctaccc gggttgttgc cgccccttga tgacgtcaaa
2345641 aacttcgtgg gcatccagaa cctggtcgcc catgagccaa tgcttcaacc ccagactccc
2345701 aacgggtcaa tcaaccccgc ggagtgctgg ccggcggttg ggggtggcgt tcctagcgcc
2345761 tacgacctgg ggaccgtcat cggcttttac gggttgacaa tcgacgagcc gcccaccggg
2345821 actgccccaa atcaagtggg gcaactgatc gtggcctttc gcgacgcggc cacagcccaa
2345881 aggcatttgg ccgatttggc gtcgatctgg cgccgatgcg ggggtcgaac cgtaacactc
2345941 ttccgtagtg agtggcgaag gcccgttgaa ctgtcgacga gcgttcccga agtcgttgat
2346001 ggcatcacca ccatggtgtt gacggcgcag ggaccggtgc tacgagtccg cgaagaccat
2346061 gcgatcgccg cgaagaataa tgtgcttgtc gatgtcgaca tcatgacgcc cgacaccagc
2346121 cgcggccagc aggcggtcat cggcatcacc aactacatcc tcgccaagat acccggctga
2346181 gcgcgacacc attggcctag gacaccggca ccacgatcaa ctcgtgcggg cagttgttga
2346241 cagacacagc accgtcctcg gtcacgatca cgatgtcctc gatgcgggcg ccccaccggc
2346301 ccgggaaata gattcccggc tcgatggaaa acgccatgcc gggaaccaac accaggtcat
2346361 tgccggcgac gatatagggc tcctcgtgca cgcacagccc gatgccgtgc ccggtgcggt
2346421 gcacaaaata ctccgcgagc ccggcctcgg cgagcacgtc acgcgcggcg gcgtccacct
2346481 gctccgctgt cacccctggg cggatggcct cgaacgccgc ccgctgggct cgctgcaaca
2346541 tcgaatatga ctgcgctaca tcagaatcag gctcgccgat gctgtaggtt cgggtggagt
2346601 cggagtggta tccaggccca tacgtgccgc cgatgtcgac gacaacgatg tcaccctccc
2346661 gcaattcgcg gtccgaatat ccgtgatgcg ggtcggcgcc gtgcggcccg gaacccacga
2346721 tgacgaacgc tacctccgaa tgcccttcgg cgacaattgc ttcggcgatg tcggcggcta
2346781 cgtcggcttc cgttcggccc gggaccagaa actccggcac tcgggcatgc actcgatcga
2346841 tcgccgcgcc ggccttacgc agcgcgtcga tctcggtttc ctccttgacc atccgcagcc
2346901 tgcgcagcac gtcggtggcc aataccggca gcacacccag tgcgtcggcc agcggcaaca
2346961 tgtgcaacgc cggcatggaa tcggtgaccg cggtcgctac cggagctccg cccaacacgg
2347021 cactcaccaa cccgtagggg tcgtcaccgt cgacccaatc gcacacgcgc agacccaatt
2347081 ccgctgcggc ggattgcttg agggcggcga gctccagccg cggcagcaca accgccggcg
2347141 caccggcggc cggcaacacc aacgcggtga gccgctcgaa cgtctccgct cgcgacccga
2347201 tgaggtaaca caggtcgtag ccgggagtta tcaccagacc cgccagaccg gcgtccgccg
2347261 tcgcggccgc cgctaaagcc agccgccgtg cataaacctc ggcgtcgaat cggcgagaac
2347321 ccatgtcagc caggttaacc gcgcgttcgc gagcgctggc aagatagccc gcatgcccgc
2347381 acccgatccg atgcgtggcg acccgccgca cccggctccg ccgcgcttgc gatcgccact
2347441 ggacccaaca agtggcgacc cgctgcaccc ggctccgccg cgcttgcgat cgccactgga
2347501 cccaacaagt ggcgacccgc tgcacccggc tccgccgcgc ttgcgatcgc cactggaccc
2347561 aacaagtggc gacccgctgc acccggctcc gccgcgcttg cgatcgccac tggtgctact
2347621 ggacggcgcc agcatgtggt tccgctcgtt cttcggtgtg ccatcatcga tcaccgctcc
2347681 ggatggccgg ccggtcaacg ccgtacgcgg cttcatcgac tccatggcgg tggtgatcac
2347741 acagcagcgg ccaaaccggc tggcggtctg cctcgacttg gattggcgcc cgcagttccg
2347801 ggtggacctg atcccgtcat acaaggcaca ccgggtggct gagcctgagc ccaacggcca
2347861 gcccgacgtc gaggaggtgc ccgacgagct gaccccgcag gtcgacatga tcatggagtt
2347921 actggacgcg ttcgggatcg cgatggcagg cgccccggga ttcgaagccg acgacgtgct
2347981 gggcacgctg gcaacccggg agcgccgcga cccggtaatc gtggtcagcg gagaccgcga
2348041 cctgctgcaa gtggtcgccg acgatccggt cccggtccgg gtgctctacc tgggccgcgg
2348101 ccttgccaag gccaccttgt tcggaccggc cgaggtcgcc gagcgctacg ggttgccggc
2348161 acatcgcgcc ggcgcggcct acgccgaact cgcgctgctg cgtggcgatc cgtccgacgg
2348221 cctacccggc gtgccaggcg tcggcgagaa gaccgccgct accctactgg cccgacacgg
2348281 ctcgctagat cagatcatgg cggccgccga cgaccgcaag accacgatgg ccaagggcct
2348341 acgtaccaaa ctgcttgccg cgtcggccta catcaaggcc gccgaccggg tggtgcgggt
2348401 cgccaccgac gcaccggtca cgctgtcgac acccaccgac aggttcccgc tggtcgcagc
2348461 tgacccggag cgcaccgccg agctggcgac ccgattcggg gttgaatcct cgatcgcgcg
2348521 actacaaaaa gcgctcgaca cgctgcccgg atgacgatta ctgtggccgg ccgacctcgt
2348581 aggtgccctt gttgtcctgg aaggtcacgg tcacgcgctt tgaggtgccg tcgatgctca
2348641 ccgtgcattc gaaggtggcg ccctttttga ccgtggggtc tgaaccgttg ttgcacttga
2348701 cgtctttgac gttcttggcg ccgtaccccg tggtctcatc ggtgagaacc tgctgcacac
2348761 cggcctgcgc cttaatgacg tccagcttgg tggtgacgaa gaatccgggt gcccagaagc
2348821 cgagtattag aaccgcgccg atgaacagca cggccatcac ggcgatcacg ccgccgatca
2348881 ccgcaaccga acgcttcgac ccctgacccg actggccata cgggccgtat tgcccggggt
2348941 actgaccggg cggtgcgtac tggccgggct ggccgtactg tcccggctgg ccatattggc
2349001 ccggctgctg gtattggccg tactgaccgg gcacgccgag ctgggtgggc tgtgcaccga
2349061 actgttcggg ctgcgcatag ccgggtgtgg gctgcgggta ctgctgcggg tacgccgggt
2349121 cagccggctg ttggtactgc ggtgtgtacg ccggggcctg ccacgtcgcc tcctgggtcg
2349181 gctgctgctg ccagggatat cccgcggcca cggtggggtc cgaggaatgg tcggcgccct
2349241 ggccgggcgg ctgccacggc tgccttgggt ccgatccctg cggtccgctc atcgcttctc
2349301 ctcagtctgt gttaaccgta actctggccc agcctacccg gcgtcaaccg cgacgacgcc
2349361 gcgccgaatg tcaccgatag cgcgctttgc ggtagcccgc agttcggggt tgggcgcagc
2349421 gttacgaact tggtccagca gatcgagcac ctgacggcac caacgcacga aatcccctgc
2349481 caataacggt gatccgctgc cgttcacgtc ggcagcggcc aatgccgccg ctagatcacc
2349541 ggttcgcgac cagcggtaga tgactctgac aaagccatcg tcgggttcgc gactcggggt
2349601 gatgcggtgt gcctgctcgt cggcgcgcaa tgtcgtggac agccttgatg tctgagtcag
2349661 agcctgccgt aaccgcggtg tgggcacatc ggctccgaac ggggcgccct ggccgtcacc
2349721 accgcgcgtc tcgtagacca ccgccgacac cacccccgcc aattcggccg gctttaaacc
2349781 ctcccacgca cctgtacgta ggcactcggc caccaacagg tcgctctcgc tgtaaatccg
2349841 cgccagcagc cggccgtcgt cggtgaccac gggatcagtg gccgggccat cgatgaactc
2349901 ccgttcggtg agcagcccga cgaatcggtc gaacgtgcgg gccaacgagt tggtggcggc
2349961 ggcgaccttc ctctctaatt gcgcgttgtc gcgttcgatg cgtaagtaac gctcggcctg
2350021 gcggatctgg tcctcgagcc cgggcgaggt atgcaccgga tgacggcgca attgttcgcg
2350081 cgacgactcc agctccggat cgtgaaaccc gccggcctcg ctgacgcgcc gggcggctgg
2350141 aataaccaga cccgcggctg ccgatcgcag cgccgaggcc aggtcacgcc ggacccgcgg
2350201 ctggcggtgc tccacccgct tgggcagcgt catcgacccc accggcgtcg tgcccgagta
2350261 gtcggccgag gagatccgtc ccgcccatcg gtgttcggtt agcaccagcg gacgcgggtc
2350321 gtcgcggtcg cgggctgatt ccaggacgac ggccagacca ccgcggcggc cgtgggtgat
2350381 ggtgatgatg tcaccgcggc gcagcgcggc cagcgcatcg gtggccgcct gccgtcgctg
2350441 taaccgcgac gcgcgggcct gcgcacgttc cagctcggac acccgcgcgc gcaatcgagc
2350501 gtattcgagg atgggcgcat cagatccgcc cagttcggct gcgatctcgc cgagtatcct
2350561 gttgccccgc tcaattccgc ggaccagtcc gaccacggat cggtcggcct gatattgggc
2350621 gaacgactgc tcgagcagtc ggtgcgcctg ttgcggaccc atccggtgca ccaggttgat
2350681 cgtcatgttg tacgacgggg caaacgagct gcgcagcgga aaggtgcggg tggaggccag
2350741 gcccgccacc tcggacggtt caatttccgg gtgccagatc accaccgcgt gaccctcgac
2350801 gtcgataccg cgccggccgg cgcgaccggt cagttgggtg tactcccccg gcgtcagcgg
2350861 catgtgctgc tcaccgttga acttcaccag ccgctccagc accaccgtgc gggccggcat
2350921 gttgataccg agcgccagag tctcggtggc gaatacagcc ttgaccaaac cggcggtgaa
2350981 cagctcctcc accgtgtgcc ggaaggccgg caacatgccc gcgtggtggg cggccagacc
2351041 gcgcagtaac ccttcccgcc attcgtagta gccgagtacc gccaggtcgg agtcggccag
2351101 gtcaccgcag cggtggtcga tcacctcggc gatccgtgcg cgctcctctt cgctggtcaa
2351161 ccgcagcggt gaccgcaggc attgggtgac cgcggcgtca caaccggccc gggagaacac
2351221 gaaggtgatc gccggcaaca gcccttcagc gtcgagtttg gcgatcacct cgggtcggcc
2351281 gggtggccgg tagaagccgg gccggcccga gcctcggcgc cgaggctgcc aatcggccat
2351341 ccggtcggcc tcacggcgat gcgcgatgtg gcgcagcaac tcgcggttga cttggggctg
2351401 cccttcggct tcgccgatcc ggtaatcgaa caggtcgaac atgcgcttgc ccaccaagac
2351461 gtgttgccac aacggcaccg gccgatgctc gtcgaccacc accgtggtgt cgccccgcac
2351521 cgtctggatc caaccgccga actcctcggc gttgctcacc gtcgccgaca ggctgaccac
2351581 ccgcacgtcg tcgggcagtt gcaggatcac ctcctcccac accggacccc gcatccggtc
2351641 ggcgaggaaa tgcacctcat ccatcaccac ataggaaagc ccctgcagcg caggcgaatc
2351701 cgcgtagagc atgttgcgca gcacttcggt ggtcatcacc accaccggcg cgttgccgtt
2351761 gaccgacagg tcaccggtca gcagcccgat ctggtcacgg ccgtagcgtg ctgtgagatc
2351821 ggtgtgcttt tggttgctca gggctttcag cggcgtggtg tagaaacatt tactgccggc
2351881 cgccagcgcc aggtgcacgg cgaactcgcc gaccaccgtc ttgccagcgc cggtcggcgc
2351941 gcacaccagc acaccgtggc cgcgttccag cgcgctgcaa gcccgctgct gaaagtcgtc
2352001 gagcgagaac ggtagttccg cggtgaaccg gtccagctcg gccagctcag tcacgtcgcc
2352061 gccgcctcgc cagttgaccg cgcccgctcg cggctagcgg gcctacgtga cgtcgtcatg
2352121 agatccgatg accgatggcg ccggcaccgg cgagggcggg tcgatgaccg aagcttcgtc
2352181 gtcgggaatc gcggcttcgc gcttggcttt tcgcttgtca tgcacgcggg cgatctgaat
2352241 ggcgagctct agcagcacgg tcaacgccgc accgagcgcg gtcatcgaga acggatcgga
2352301 tccgggcgtg aagatcgccg cgaagacgaa catcgcaaag atcaacccgc gccgccaaga
2352361 cttgagccgc tcataggtca gcaggcccgc caggttcagc atcacgatca gcagggggaa
2352421 ttcgaagctg accccgaaca ccaccagcag gttgagcaga aagccaaagt agcggtcgcc
2352481 agacagcgcg gtcacctgca cgtcgctgcc gacggtcaac aaaaagccca acgccttgga
2352541 caacaccagg taggccagta cggcaccggc gacgaacagc accgctgctg ggatcacgaa
2352601 ggccaccgcg aagcggcgct ccctctggta gagaccaggc gtgatgaacg cccacagctg
2352661 gtagaaccac accgggcaag ccagcacaat gccggcggcc atcccgacct tgagccgcaa
2352721 catgaactgg tcgaacggcg cggtggccaa caaacggcac tctccgtcgg cgctgatatc
2352781 cgcccgggcc gactgcggca gggcacagta gggatgccgc agccactctc cgaggctgtc
2352841 caacccgaaa atcgaatgcg aataccagac gaacccgaag attgtggtga ccaagatcgc
2352901 ggccagggag atcagcaacc tggtgcgtaa ctcggtcagg tggtcgacca gcgacatcgt
2352961 cgcgtcagga ttgacgcggc tgcgcctgtt acgtgggttg agccgtttga gaagaccggc
2353021 ggcgcgcact gaagcgacgc ccgagctaag ccggccgagc ctcggtgctg tcttgaccag
2353081 acgccgctga ggggtcgaca cgctgcgatt gcaccggcgt gggggtctcg atagacgctt
2353141 ccgctttgtt ctcgttctgc agttcacgga cctcggactt aaagattcgc aatgacttgc
2353201 ccaacgagcg cgccgcatcg gggagcttct tggcaccgaa caacacgatc accacgacag
2353261 cgaggatcgc ccaatgccac ggactcagac tgcccacttt gattacctcc agacgttgac
2353321 ccgatgctac cgcagcggcc gcggcacccg gagatttcgc gccgtcacgg cggcgcagct
2353381 gcctggtatg catccagcgc ggccgtcgcg gcgtcgcgaa cccgctgagc gagcgactcc
2353441 ggcgccagaa cgcgcacgtc cgaaccgaag cccagcaata ggcgcgtcat ccaatcctca
2353501 gaggcgtagg tcatggccac ctcacaggag ccgtccggca gctgtcgtag ctcccgaatc
2353561 gggtagtact ccagcatcca cgaggccgac ggtgccaccc gcaacgtcgc cgacggcagc
2353621 gataggtcac cgtcgaacag cgacgtgtcc ggtggcgcct gccgtgccga ttccggcgga
2353681 accgcgggct cgcccaactc ggcggcatcg acaatccggt cgaaacggaa caggcgaacc
2353741 ccttcggcct cacgcgacca ggcctccaaa tagctgtgcc cgccgatcaa cagcacccgg
2353801 atgggatcca cgatccgagt ggtgagggtg tcatgcgacg cggcgtaata gtcgatggtc
2353861 agcgcccgac tgttccgcac cgcggcccgt acggccgcgg cggccgggct ttctgtgggt
2353921 gcctgttcgg caacggcggc caccgcgccg gccgcggcgg cgatcttggc gatggcgctg
2353981 cgcgccgcct gcgggtcaac cacgccggga atgtccgcta gcgcccgcaa cgccaccagc
2354041 agcccggtgg cctccggcga tgtgagcttt aacggccggt cgatgcccgc cgagaacgtc
2354101 acctcgatgg tgtcaccgca gaattcgaag tcgatgaggt cacccgggga atagcccgga
2354161 aggccgcaca tccacagctg gttgaggtcc tcctccagct gcttggcggt gacacccagc
2354221 tcggcggcgg cctcggcgcg ggtgatccgg gggttggcct ggaagtacgg caccatgttg
2354281 agcagccgca ccagccgggt ggacagggcg ctcatgccag tgctccggct tgcgcgcgta
2354341 gtcgggccag cacatcgtcg cgcagagacc cgggctgcag cacgattgcg tcggccccat
2354401 agccggtgat ctcacgcgcc agccggtcgc tggatcgaat ctcaagctcg atcacctcgc
2354461 catcgcgacc accaagttgt cgcggcccgg cggaccgccc ggcacgtcgc aacgcggtgg
2354521 cccgaccctc ggctacccat accgtggctt gctcaccggt cggcacctcc gtcaccttct
2354581 gcgccacgat gctgcgtagg tccacaccgg caggcacggt ggttgcgccg gccggcccga
2354641 ttggcgtcac ctgcgctccg atccgggaca gccggaagac gcgggttgca tcccggtcgc
2354701 ggtcgtggcc gaccagatac cagcggccct tctcggtaac cacaccccac ggctcgacgg
2354761 tccgaacggt gtacggctct gcgcgcgacg atcgatgaga gaactgcacc acctgcccgg
2354821 aatcgatggc cgacaacaag attccgagaa cgtcctcaga gccgcgcagt cccgaaacgg
2354881 ccgccgccga cgcgatggcc accggtgccc cggtatccaa gggatcgacg tccaccccgg
2354941 cggcccgcag cttcagcaac gcgccctggg tcgcggtgat caactccggt gactcccaca
2355001 gctgggtggc gacggctacc gcggccgcct catccggggt cagctcgaca ggcgacaggg
2355061 cgtaggcgtc gcggttgatg cgatagccct cggtgggctc caacgccgag accctgccga
2355121 cctcgagcgg aatgccgagg tcacgcagct cgttcttgtc gcgctcgaac atccgggaga
2355181 acgcctcaac gctggggctg tccgaatagc ctgccacgct ggacctgatc ttctccgcag
2355241 tgatgtagcc acgagtggac agcaaggcta tgacgagatt gaccagccgt tcgactttcg
2355301 aggtcgccat tggtggtgct acatgctcgc gatcagccgc ttaacccgct catcgaccgc
2355361 ccggaacggg tctttgcaca gcacggtgcg ctgcgcctgg tcgttgagtt tgagatgtac
2355421 ccagtcgacg gtgaaatcac gtcccgcctc ctgcgcggcg ctgatgaact caccgcgcag
2355481 ccgggcccgg gtggtctgtg ggggctgatc gacggcctcc gcgatttctt cgtcggtggt
2355541 gacgcgcgcg gccaaccctt tgcgctgcag gagatcaaag atcccgcgtc cgcgcttgat
2355601 gtcgtggtag gccagatcca gctgagcgat cttcgggtgg gacaactcca tgtcatagcg
2355661 gtcctgataa cgctgaaaca gcttgcgttt gatcacccag tcgatttcgg tgtcgacctt
2355721 ggcgaaatcc tggctttcga cggcatcgag ttggcggccc cacaggtcga cgacctgctc
2355781 gatctgcgcg ttgggctccc gagtctgcaa gtgctcgact gcgcgggtgt agtactcccg
2355841 ctggatgtcc agcgcgctgg cctgacggcc tccggccaac cgcaccggcc ggcgaccggt
2355901 gacatcatgg ctaacctcac ggatggcgcg gatcgggtta tccagggaaa aatcacggaa
2355961 ggcgactcca ctttcgatca tttccagcac gagcgccgcg gtgcccacct tgagcatggt
2356021 ggtggtctcg gacatgttgg agtcgccgac gatgacgtgc agccgccggt acttctcggc
2356081 gtcggcatgt ggctcgtcgc gggtgttgat aatggggcgg gatcgggtcg tggcgctaga
2356141 gacgccctcc caaatgtgtt cggcgcgttg gcttaagcag taggtggcgg ccttgggggt
2356201 ctgcagcacc ttgccggccc cgcagatcag ctggcgggtg accaggaagg gcagcagcac
2356261 gtcggagatc cgggagaact caccggcccg cacgatcagg tagttttcgt ggcagccgta
2356321 ggagttgccc gccgaatcgg tgttgttctt gaacaggtag atgtcgccgc cgatgccctc
2356381 gtcggccagc cgctgctcgg cgtcaacgag caggtcttcc agcacccatt caccggcccg
2356441 gtcatgggtg accagctgca ccaggctgtc gcattcggcg gtggcgtact cgggatgact
2356501 gcccacgtcg agatacaggc gcgcaccgtt acgcaggaag acgttggagc tgcggcccca
2356561 ggacaccaca cggcgaaaca ggtagcgggc cacctcgtcc ggggacagcc gacggtgacc
2356621 gtgaaatgtg caggtgacac cgaactcggt ttcgatgccc atgattcgac gctgcacgta
2356681 tttgagggta ctggttgttg gttggcggcg gcgcgatagc cacgcccgtt acccgtccgg
2356741 gccggacggg ccggggactc cgaacagcag cccgccggtg ccgccgctgc cgccgggccc
2356801 cgcggccccg tccggagtac cgggtccgcc ggcggcgcca gccccaccgg cgccaccgtc
2356861 gccgaacaag atggcggtgc cgccgtgccc gccgacaccg cccggcccgc cgggcgaggt
2356921 ggtgttcatg ccgggccccc cttggccggc ggccccgccg gcgccaccgt tgccgtacca
2356981 cacgccgccg ttgccaccgc tgccgccggg gttgcccgcg cccccgacgc caccgctgct
2357041 gaccgagcca ggcgcgccgc tcccgccgct accgccggca ccaccgttgc cgatgagccg
2357101 cgcgctgccg ccgttgccgg cgttggtgga gccaataaat ggcagccccc cattaccgcc
2357161 gtcgccgccg ccgccgccat cgccgtacag ccacccgccg accccaccgt cgccgccgcg
2357221 actacctacc tggaacaggc gcgcaccgag ccctgggtcg ccgccgttgc cgccgccgcc
2357281 gccgccgaca ccaatcagcc ccgcgtcgcc gccccggcca ccgctgccgc ccaacccggc
2357341 gaaaccgtcg ctggagacgc cggtacctgc atcgccaccg ttgccgccgg aaccggccgc
2357401 ccctccattg ccgtacagca gcccgccggc gccaccgaac tggccgaagc cgccactgcc
2357461 gccactgccg ccggccttgc cgctcccgcc gtgcccaccg tccccaccgt ttccgccggc
2357521 accgccgtga ccgatcagcc ccgcccgtcc acccaaaccg ccatcgcctc ccccgccgcc
2357581 agcaccgagg tctcccacac cgttgtcacc ggtaccgccg actcccccgg cacccccgtt
2357641 gcccagcagc aatccgccca ggccgccatt gcctcctgca ccgccgggcg caccgttgcc
2357701 gcccctgccg ccgttgccga tcagccccgc tgacccgccg gctcccccgg caaccccggg
2357761 gctcgtgctg tcgccaccgt tgccgccgtt gccccacaag atgccgccgt ccccgccggg
2357821 ctgtcccacc ggaccactgg ccccgtcggc gccgtcgccg accagcggac gccccagcag
2357881 cgtctgggtg ggcgcgttca ccgcgttcag caggttctgc tgcgcgttgg caatctcggc
2357941 gctcgcatat gaacctccac cggcgttaag cagttggacg aaccggtcat gaaacgccgc
2358001 cgcctgggcg ctgaccgctt gatagctctg gcctgggcgc caaatagcgc cgctatgccc
2358061 gccgacacct catcggcggc gggcgccaac gcccccgtcg tcgggaccgc cgccgccgcg
2358121 ttcgctgccc tgatggtcga acggatggcc gctaaatccg tggccgcagc cagcaatgcc
2358181 tccgggctcg caatcacaaa cgacattgcg cacctcccac caacccgcga taacccggct
2358241 gcgccggaac cgtcgatgcg tatggcagga atatcgtatt gcgatccccc accctcagtc
2358301 ggggtgttcg ccagattcgt cgcagctcag cgctgcgccg gcgccagcat tggcgatggc
2358361 tggtggttaa cgcgagtggt cgaaggtgat ggccggggca ctgttcgaac cgtcgttcgc
2358421 cgcagcgcac ccagcggggc ttctcagacg acccgtgacg cgaaccgtcg tgctgtcggt
2358481 ggccgctact agtatcgcac acatgttcga gatatcgctg ccggacccga cggagctgtg
2358541 ccgatccgat gatggcgcgc tggtggccgc gatcgaggac tgcgctcgtg tggaggcggc
2358601 tgcgagcgcc cggcggttgt cggcgatcgc cgagctgacc ggccggcgca ccggcgcgga
2358661 ccagcgggcc gactgggcgt gtgacttctg ggactgcgcg gccgcggagg tggctgcggc
2358721 gttgactatc agccacggca aagcctccgg acaaatgcat ctgagccttg ccctgaaccg
2358781 gctgccccag gtggcggcgt tgtttttggc cgggcatctt ggtgcgcggc ttttctcgat
2358841 catcgcctgg cggacctacc tcgttcgcga cccgcacgca ctgagtctgc tcgatgccgc
2358901 cctggccgaa cacgccggcg cgtgggggcc gctgtcggcc cccaaactgg aaaaggccat
2358961 cgactcctgg atcgatcgct acgatcccgg ggcgctgcgg cgcagccgta tctcggcccg
2359021 cacccgcgac ctatgcatcg gtgatcccga tgaggacgcc ggcaccgccg cgctgtgggg
2359081 ccggctgtat gccaccgacg ccgcgatgct ggatcgccgg ctcaccgaga tggcccacgg
2359141 cgtgtgcgag gatgacccgc gcaccctggc ccagcgccgc gccgacgcgc tgggcgcgct
2359201 ggccgccggc gccgaccacc tggcgtgcgg ctgcggcaag cccgactgcc cctccggtgc
2359261 cggcaacgac gagcgggccg ccggtgtggt catccacgtc gtcgccgacg cctcagcact
2359321 tgacgcacaa cccgacccac acctatccgg cgacgaaccc ccttcgcggc ccctcacccc
2359381 ggagacgacc ctgttcgagg cgttgacacc cgaccccgaa cccgatcccc ccgccaccca
2359441 cgcgccggcc gagctgatca ccaccggcgg cggtgtggtg cccgcgccgc tgctggccga
2359501 actcatccgg ggtggggcca ccatcagcca agtgcgccat cccggcgatc tcgcagcaga
2359561 gccgcactac cggccgtcgg ccaagctggc tgaattcgtc cggatgcggg atttgacgtg
2359621 ccggtttccc gggtgtgacg tgcccgccga gttttgtgat atcgaccatt cggcgccctg
2359681 gccgttgggg ccgacgcatc catcaaatct gaagtgcgcg tgtagaaaac accacctttt
2359741 gaaaactttc tggacgggct ggcgggatgt gcagttaccc gatggcacgg tcatctggac
2359801 cgcgcccaac ggccacacct acactaccca tcccggcagc cgcatcttct ttcccacctg
2359861 gcacaccacc accgccgaac taccccaaac atcaacggca gcagtcaacg tcgacgcacg
2359921 cggcctgatg atgccgcgac ggcgccggac ccgagccgcc gagctggccc accgcatcaa
2359981 cgccgaacgc gccctcaacg acgcgtacat ggccgaacgc aacaagccac catcgttctg
2360041 atgggcggct attcccacct catgtcaaac accccttctg gatgtcacgc cccttctgga
2360101 caccaccgac gagttctcgt gtcgccgcac ctatccaaga agaccaaccg ctacgatcgg
2360161 tcgatgtcgc ggcgccgcag tcgacgcagg agaaccgcga aacgtgccgg ccgctccgtc
2360221 gacaagagag aaggactgca tgctggtttt gcacggcttc tggtccaact ccggcgggat
2360281 gcggctgtgg gcggaggact ccgatctgct ggtgaagagc ccgagtcagg cgctgcgctc
2360341 cgcgcggcca cacccgttcg cggcgcccgc tgacctgatc gccggcatac atccgggcaa
2360401 acccgcaacc gccgttttgc tgttgccgtc gttgcgatcg gcgccgctgg actcgccgga
2360461 gctgatccgg ctcgccccgc gcccggccgc gcgaaccgat ccgatgctgt tggcgtggac
2360521 ggtaccggtg gtggacctgg accccaccgc ggcgttggcc gccttcgacc agcccgcccc
2360581 cgacgtccgc tacggcgcgt ccgtcgacta cctggccgag ctggccgttt tcgcgcgcga
2360641 gttggtcgag cgtggtcgcg tgctgcccca gctgcgccgc gacacccacg gcgcggccgc
2360701 ctgctggcgt ccggtgttgc agggacgcga cgtggtcgcg atgacctcgc tggtctcggc
2360761 gatgccgccg gtctgccgcg ccgaagttgg tgggcacgac ccgcacgaac tggcaacctc
2360821 ggctctggac gcgatggtcg acgccgccgt gcgcgcggcg ctgtcaccga tggacctgct
2360881 gcccccgcga cggggtcgct ccaaacggca tcgggccgtg gaggcttggc tgaccgcgtt
2360941 gacctgcccg gacggccggt tcgacgcgga gcccgacgaa ctcgacgcgc tggccgaggc
2361001 gttgcggcca tgggacgacg tcggtatcgg caccgtcggc ccggcgcggg cgacgtttcg
2361061 gctgtccgaa gtcgagaccg aaaacgagga gacgcccgcg ggctcgttgt ggaggctgga
2361121 gttcttattg cagtcgacgc aggaccccag cctgctggtc cccgccgagc aggcatggaa
2361181 cgacgacggc agcctgcgcc gctggctgga ccggccgcag gagctgctgc tgaccgaact
2361241 gggccgggcc tctcggattt tccccgagct cgtcccggcg ctgcgcaccg cgtgcccgtc
2361301 cgggcttgag ctcgacgccg acggcgccta ccgattcctg tcgggtacgg ccgcggtgct
2361361 cgacgaggct gggtttggcg tgctgctgcc gtcctggtgg gaccgccgcc gcaagctggg
2361421 cttggtcctg tccgcatata ccccggtcga cggcgtggtg ggcaaggcca gcaagttcgg
2361481 ccgcgagcag ctcgtcgagt tccgctggga gctggccgtg ggcgacgatc cgctcagcga
2361541 ggaggagatc gcggcgctga ccgaaaccaa gtccccgctg atccggctgc gtggccagtg
2361601 ggtcgcgctc gataccgaac agctgcgccg cgggctggag tttttggagc gtaagccaac
2361661 cggccgcaag accaccgccg agatcctcgc gctggccgcc agccaccccg acgacgtgga
2361721 caccccgctc gaggtcaccg ccgtacgcgc cgacggctgg ctcggggacc tgctcgccgg
2361781 ggccgccgcg gcgtcgctgc agccgttgga cccgcccgac ggattcaccg cgacgctgcg
2361841 tccctaccag cagcgcggtc tggcgtggct ggcgtttttg tcctcgctcg gtttgggcag
2361901 ctgcctggcc gacgacatgg gcctgggcaa gacggtgcag ctattggccc tggaaacctt
2361961 ggaatccgtt cagcgccacc aggatcgcgg cgtcggaccc acactgctac tgtgcccgat
2362021 gtcgttggtg ggcaactggc cgcaggaagc ggccaggttt gcacccaacc tgcgggtgta
2362081 cgcccaccac gggggcgccc ggctgcacgg cgaggcgttg cgcgaccacc tcgagcgcac
2362141 cgacctggtc gtgagcacct ataccaccgc cacccgcgac atcgacgagc tggcggaata
2362201 cgaatggaac cgggtggtgc tggacgaggc ccaggcggtg aagaacagcc tgtcccgggc
2362261 ggccaaggcg gtgcgacggc tacgcgcggc gcaccgggtc gcgctgaccg ggacaccgat
2362321 ggagaaccgg ctcgccgagc tgtggtcgat catggacttc ctcaacccgg gcctgctcgg
2362381 atcctccgaa cgcttccgca cccgctacgc gatcccgatc gagcggcacg ggcacaccga
2362441 accggccgaa cggctgcgcg catcgacgcg gccctacatc ctgcgccggc tcaagaccga
2362501 cccggcgatc atcgacgatc tgccggagaa gatcgagatc aagcagtact gccaactcac
2362561 caccgagcag gcgtcgctgt atcaggccgt cgtcgccgac atgatggaaa agatcgaaaa
2362621 caccgaaggg atcgagcggc gcggcaacgt gctggccgcg atggccaagc tcaaacaggt
2362681 gtgcaaccac cccgcccagc tgctgcacga tcgctccccg gtcggtcggc ggtccgggaa
2362741 ggtgatccgg ctcgaggaga tcctggaaga gatcctggcc gagggcgacc gggtgctgtg
2362801 ttttacccag ttcaccgagt tcgccgagct gctggtgccg cacctggccg cacgcttcgg
2362861 ccgtgccgcc cgagacattg cctacctgca cggtggcacc ccgaggaagc ggcgtgacga
2362921 gatggtggcc cggttccagt ccggtgacgg cccgcccatt tttctgctgt cgttgaaggc
2362981 gggcggtacc gggctgaacc tcaccgccgc caatcatgtt gtgcacctgg accgctggtg
2363041 gaacccggcg gtcgagaacc aggcgacgga ccgggcgttt cggatcgggc agcggcgcac
2363101 ggtgcaggtc cgcaagttca tctgcaccgg caccctcgag gagaagatcg acgaaatgat
2363161 cgaggagaaa aaggcgctgg ccgacttggt ggtcaccgac ggcgaaggct ggctgaccga
2363221 actgtccacc cgcgatctgc gcgaggtgtt cgcgctgtcc gaaggcgccg tcggtgagta
2363281 gcacctggta tccaccaccg tcccggcccc gtccggtcga gggtgggatc aaggcgcgca
2363341 gcacccgcgg cgcgatcgcg cagacctggt ggtcggagcg gttcattgcg gtgctggagg
2363401 acatcggcct gggtaaccgg ctgcagcgtg gccgcagcta tgcgcgcaag gggcaggtga
2363461 tctcgctgca ggtggatgcc ggcttggtca ccgcgctggt gcagggcagc cgggcccggc
2363521 cgtaccggat ccgcatcggg attccggcgt tcggcaagtc gcaatgggcg cacgtcgagc
2363581 gaaccctggc cgaaaacgct tggtacgcag caaaattgct gtccggcgaa atgcccgaag
2363641 acatcgagga cgtcttcgcc ggcctgggcc tgtcgctatt ccccggcacc gcccgagagc
2363701 tatcactgga ctgctcctgc cccgactacg cggtcccatg caagcacctg gccgccacct
2363761 tctacttgct ggccgagtcc ttcgacgagg atccgttcgc catcctggcg tggcgtggcc
2363821 gcgagcggga ggatctgctg gccaacctgg ccgctgcccg cgccgacgga gcggcaccgg
2363881 ccgccgacca cgccgaacaa gtggcccagc cgctcaccga ctgcctagac cgctattacg
2363941 cccggcaggc cgacatcaat gtccccagcc cgccggcaac cccatcgacg gcattgctcg
2364001 accagctgcc cgacaccgga ctcagcgccc gcggacggcc gctgaccgag ctcctgcgac
2364061 ccgcctatca cgccctgacg caccatcaca acagcgcggg cggctgatcc cagcgcaccc
2364121 cttcgaatcg gccgaagtca ctgtcgtagg acacgatgct ggcgcgatgc tcgacggcaa
2364181 gcgcggccag atgcgcgtcg ttgaccaggt tggcaccggt tcccacgtac gtcagcattc
2364241 tcgccaggat atcggcgtgc cggacggtcg gattcaccaa gacggcgctg ggtgcggcta
2364301 gccaatccgc gacctgggtg atggccgcct cccgcggaag cggacggggg aacaacccca
2364361 ccttggtcgc caatcgcacg aacgccaaca acggcaccca ggcgaacccg acgcggtcgg
2364421 cgcccgacag cgcaccgtca agccagcgca gcgacggctt gtggtgctca cttgtggtgt
2364481 tcacggcgta gagcaagacg ttcgcgtcga cgatcttcat caaccgctat gacccgcggc
2364541 gttgacggcg cacaagctct tcgtcctcga ggtcggccgc aagctgcaag gcccggtcga
2364601 ggttgaccgc agggacgccc aagtctgccg tgcgggtgct gaagtgactc ggcgcaggtc
2364661 gcccggaggc gccgtcgcga atcgcgtcgt tgagggcctt cttgaaggac acttgccgct
2364721 cggccatccg gcgccttacc aactgctcga cgtcgtcatc caatgtgaca gtcgtccgca
2364781 ttttgatagc atagcatcaa gattgtcgac agcatctcgt caatcggcgc gcgggcccgt
2364841 cactaatccg gcgattcgcc gtcggactgg gagtctttgg cgcccgtgga acccctttgt
2364901 gtcccttggc atctttgcga tccagttccc gcagccgttt tcccaacgcg gcacccgcga
2364961 tgcgccgaaa cgcgcgccgt agccggtcgg cgtcgagcac ggccacctcc agggtggcca
2365021 ggggtgggtt gagcaccacg gtcgtgaacg tcattcgcgg tagcccgact cggcgacctc
2365081 gagcagtcga cacgccttct gcacgggaag tccttctgcg gccatcgttg ctatggccgc
2365141 ttactgcctt ctagtccgtg cggctctcgc aacagctcac gggacctttt tgaggatcgc
2365201 cacttcaggt cttcaactcg cggatgccct cattggcaac gtttgcgcct gccttggggc
2365261 ggccggcagc caccaagtcg agcactttgc ggcggaacta ctcggggtaa cacttcggca
2365321 cggacacggc tcgttcgacg gacgtcgtga ccagaagtcg agcaaaccga ctccactcta
2365381 gctagtgata caagcttttt tgtagccgcg cgatgaaccg ccccggcatg tccggagact
2365441 ccagttcttg gaaaggatgg ggtcatgtca ggtggttcat cgaggaggta cccgccggag
2365501 ctgcgtgagc gggcggtgcg gatggtcgca gagatccgcg gtcagcacga ttcggagtgg
2365561 gcagcgatca gtgaggtcgc ccgtctactt ggtgttggct gcgcggagac ggtgcgtaag
2365621 tgggtgcgcc aggcgcaggt cgatgccggc gcacggcccg ggaccacgac cgaagaatcc
2365681 gctgagctga agcgcttgcg gcgggacaac gccgaattgc gaagggcgaa cgcgatttta
2365741 aagaccgcgt cggctttctt cgcggccgag ctcgaccggc cagcacgcta attacccggt
2365801 tcatcgccga tcatcagggc caccgcgagg gccccgatgg tttgcggtgg ggtgtcgagt
2365861 cgatctgcac acagctgacc gagctgggtg tgccgatcgc cccatcgacc tactacgacc
2365921 acatcaaccg ggagcccagc cgccgcgagc tgcgcgatgg cgaactcaag gagcacatca
2365981 gccgcgtcca cgccgccaac tacggtgttt acggtgcccg caaagtgtgg ctaaccctga
2366041 accgtgaggg catcgaggtg gccagatgca ccgtcgaacg gctgatgacc aaactcggcc
2366101 tgtccgggac cacccgcggc aaagcccgca ggaccacgat cgctgatccg gccacagccc
2366161 gtcccgccga tctcgtccag cgccgcttcg gaccaccagc acctaaccgg ctgtgggtag
2366221 cagacctcac ctatgtgtcg acctgggcag ggttcgccta cgtggccttt gtcaccgacg
2366281 cctacgctcg caggatcctg ggctggcggg tcgcttccac gatggccacc tccatggtcc
2366341 tcgacgcgat cgagcaagcc atctggaccc gccaacaaga aggcgtactc gacctgaaag
2366401 acgttatcca ccatacggat aggggatctc agtacacatc gatccggttc agcgagcggc
2366461 tcgccgaggc aggcatccaa ccgtcggtcg gagcggtcgg aagctcctat gacaatgcac
2366521 tagccgagac gatcaacggc ctatacaaga ccgagctgat caaacccggc aagccctggc
2366581 ggtccatcga ggatgtcgag ttggccaccg cgcgctgggt cgactggttc aaccatcgcc
2366641 gcctctacca gtactgcggc gacgtcccgc cggtcgaact cgaggctgcc tactacgctc
2366701 aacgccagag accagccgcc ggctgaggtc tcagatcaga gagtctccgg actcaccggg
2366761 gcggttcacg attgggccgc ccgtaaggaa tgcgtcatga gcgacttcgc atcacgggcg
2366821 accaatcatt aatttgtcaa accctttgac atgcactact tgtccacatt ttgtacacga
2366881 aatacctaac acactatggt gcacatcacg cacttccacg ttccgtattc ggtgtacgat
2366941 tttgtcacgc aactaagcgt tcaagaggga gtactatgac tcatccaaaa gtaaaagatg
2367001 acatagaaat agaagagtcg tggttccggt gcgggtagct cccgatggct tgactgtggt
2367061 aagcaccagt ggcgtgttcc ccgtggttga gaccaggaag ttttaaagtc ctacagcccg
2367121 cggtattccg cagaggacat tgtgtgcatt tcgcaccttc gggtgggaga aatcgggatg
2367181 atctcaccac cggccaccgg tgggcgcact ttgtaccctt cgattccgtt attcggcgga
2367241 tttaagcagt tcgcaccatt accaagcagc caatgaggaa gagcgcaggt gactaggtcg
2367301 cttgatcttt ccctgtgcag tagctcgggt tctttgagtt tcgaggagga gaaaccacat
2367361 gtcctttgtg aatgtagacc catttgggat gttggcggca gctgcgacac tggagtccct
2367421 tggttcccac atggcggtaa gcaatgccgc ggtggcctcg gtgaccacca aggttcctcc
2367481 cccggccgcc gactacgtat caaaaaagtt atcgctgttc tttagtagcc acgggcagca
2367541 gtaccaggtg caagccgctc ggggcacggc ctttcatcga aaattggtcc ggaccctggc
2367601 gaatggcgcg cttgcgtatg aggaagtcga gatcgccaac aacgaaggtt tctaacgtgt
2367661 cgccagttac gcacgagtgg ctaccagcga gtacaaggga gtaacgaatt atgcccaatt
2367721 tctgggcgtt gccgcccgag atcaactcca cccggatata tctcggcccg ggttctggcc
2367781 cgatactggc cgccgcccag ggatggaacg ctctggccag tgagctggaa aagacgaagg
2367841 tggggttgca gtcagcgctc gacacgttgc tggagtcgta taggggtcag tcgtcgcagg
2367901 ctttgataca gcagaccttg ccgtatgtgc agtggctgac cacgaccgcc gagcacgccc
2367961 ataagaccgc gatccagctc acggcagcgg cgaacgccta cgagcaggct agagcggcga
2368021 tggtgccgcc ggcgatggtg cgcgcgaacc gcgtgcagac cacagtgttg aaggcaatca
2368081 actggttcgg gcaattctcc accaggatcg ccgacaagga ggccgactac gaacagatgt
2368141 ggttccaaga cgcgctagtg atggagaact attgggaagc cgtgcaagag gcgatacagt
2368201 cgacgtcgca ttttgaggat ccaccggaga tggccgacga ctacgacgag gcctggatgc
2368261 tcaacaccgt gttcgactat cacaacgaga acgcaaaaga ggaggtcatc catctcgtgc
2368321 ccgacgtgaa caaggagagg gggcccatcg aactcgtaac caaggtagac aaagagggga
2368381 ccatcagact cgtctacgat ggggagccca cgttttcata caaggaacat cctaagtttt
2368441 gattcgggaa catcctaaga aacggggggc gtcgccgttg gagacgtcgc aacgtgtccg
2368501 cagtcccaag ggcaacagtg aagggcccac ggtgcgatcc ccaacacccg gctagagtgc
2368561 gcataatatt ttcccgcctc ggctcaaggc gtgcaccccc atcaccgcta accatgctgt
2368621 gtatcaacag atttcattgt cccggccgtc gcgcgaccga ccaatagggt gagttccatg
2368681 tgcgatatcg cctaacagcc ggctcccgta ctcccgtggc cgatgtgatt attgattacg
2368741 tggatcacca tgtgggtgat cgcggtcgac agctttggta ccgagcacat cgccacaacg
2368801 cgcggtacga atctagtaca caaatccgca ccagccgcca tgcgacttcg caggtcatag
2368861 ccccgcagag tcgccgaacc tgccgcagtg acaaaagtca ggacggccgg cgacgcgtcg
2368921 agccggggtt aggcgcagtt aacgtcgcag cggggtccca gacacgcgtc ggactttcgg
2368981 actcagcccg acgattcgcc gtcagactgc gggctttcct ggtctaccag caacgcttgc
2369041 agggcggagc cggtgatgcg ccggaacgcg cgccgtggcc ggttggcatc gagaacggcc
2369101 acctctaagc tggccacgcc aagggtgggt tgatcaccac ccgaggtgtc ggcactgccg
2369161 gcccgcaatg cagcgaccgc gatacgcagg gcgtcggtca ggctggcgtt ctcggcatac
2369221 gactctttga gcgcgttggc gatcggctcc gtggtgccgc ccatcaccac gaaatgcggc
2369281 tcgtcggcga tcgacccgtc gtaggtaata cgatacaact cagggcgttt cgtctcgccg
2369341 taatgcgcca cctcggccac acacaactca acctcgtagg gcttggcctg ttcggtgaag
2369401 atggtgccta gagtctgcgc gtagacattg gccaactgcc gacccgtgac gtcacgacgg
2369461 tcataggcgt aaccgcgggt gtcggcgaac tggatcccgc cgcggcgcaa attgtcgaac
2369521 tcgttgaact tgcccgcagc cgcaaaaccc acccgatcgt agagctcact gatcttctgc
2369581 agcgaccgcg acggattctc cgcgacgaac agcacaccac cggcataggc cagcgccacc
2369641 acgcttttgg cccgcgcaat gcccttacgc gccaactcgc tgcgctcgcg catcgcctgc
2369701 tcaggcgaga tgaaatacgg aaaactcact tctcaccgcc atcggagccg aaagtatccg
2369761 cacccgaacg gctttcgatg atcgcgcggg ccaattcggc aatccggctc tccggcacgt
2369821 caaccgcccc gtcggcgtcg atgatcaccg ccgtcggaaa gatgccccgc accaggtccg
2369881 gaccgccggt ggcggagtcg tcgtcggcgg cgtcgtagag cgcctcgacc gccacccgca
2369941 gccccgaatc accgtcggta acctgcgaat acaacttctt catcgacgac ttcgcgaaca
2370001 gcgaacccga gcccaccgcc tgatagccct cttcctcgat gttccaaccg ccggcggcgt
2370061 cgaacgaaac gatacgaccc gcgctctgcg ggtcagacgc atgaatgtcg tagcccgcca
2370121 gcaacggcaa cgccagcaga ccctgcatcg cggccgccag attgccacgc accataatcg
2370181 ccagccggtt gattttgccg gcaaacgtca gcggcacacc ctcgagcttc tcgtagtgct
2370241 caagttccac ggcatacagc cgggcaaact caaccgcgac cgcagccgtg ccagcgatgc
2370301 cggtagcggt gtagtcatcg gtgatataca ccttgcgcac atcacgccca gaaatcatgt
2370361 tgccctgcgt cgaacgccgg tcacccgcca tgacaacacc gccggggtat ttcagcgcga
2370421 caatggtggt gccgtgcggc agttgcgcat cgccgcctgc gagtggcgca ccgccgctga
2370481 tgcttgccgg cagcaactcc ggcgcctggc ggcgcaggaa gtcagtgaaa gaagataggt
2370541 ctacagcggg tgttccagag agtgaattaa tggacaggcg atcgggcaac ggccaggtca
2370601 ctgtccgccc ttttggacgt atgcgcggac gaagtcctcg gcgttctcct cgaggacgtc
2370661 gtcgatttcg tcgagcagat cgtcggtctc ctcggtcagc ttttcgcgac gctcctggcc
2370721 cgcggcggtg ctgccggcga tgtcgtcatc atcgccgccg ccaccgccac gcttggtctg
2370781 ctcttgcgcc atcgccgcct cctgcttcct catggccttt caaaaggccg cgggtgcgcg
2370841 tcacacgccc gctgtctttc tctaccctac cggtcaacac caacgtttcc cggcctaacc
2370901 aggcttagcg aggctcagcg gtcagttgct ctaccagctc cacggcactg tccaccgaat
2370961 ccagcaacgc accaacatgc gccttactac cccgcaacgg ctccagcgtc gggatgcgaa
2371021 ccagcgagtc gccgcccagg tcgaagatca ccgagtccca gctagccgcg gcgatatcag
2371081 ccccgaaccg gcgcaggcat tcgccgcgga aatacgcgcg ggtgtcggtc ggcgggttct
2371141 ccaccgcact cagcacctgg tgttcggtga ctaaacgctt catcgagccg cgcgcgacca
2371201 gccggttgta caggcccttg tccagccgga catcggagta ctgcaggtcg acgaggtgca
2371261 gccggggcgc cgaccagctc aggttctccc gctgccggaa accgtcgagc agccgcagtt
2371321 tggccggcca gtccagcagc tccgcgcaat ccatcgggtc acgctcgagc tgatccagca
2371381 cgtgtgccca ggtttccacg atgtcggccg cccgcgggtc cgggtcgcgg ctatccacca
2371441 acttagccac tcggtccagg tagatccgtt gcagcgcaag accggtcagt tcccggccgt
2371501 cggccagcgc aacggtcgct cgcagcgacg gatcgcggga gattgcgtgc accgcatgta
2371561 ccgggcgggc cagcgccagg tcggtcagat ctattgcgtg ggctggtcct tcttcgatca
2371621 ggtcgagcac cagcgccgtg gtacccaact tcagataggt cgacgtctcg gcaaggttgg
2371681 cgtcgccgat gatgacgtgc agccggcggt acctgtcggc gtcggcgtgc ggttcgtcgc
2371741 gggtgttgat gatgccgcgc ttgagcgttg tttccagccc tacctcgacc tcgatgtagt
2371801 ccgaacgctg ggatagctgg aagccgggct catcacccga gggcccgatg ccgacccggc
2371861 ccgagccggt caccacctgc cgggatacca gaaagggggt cagcccggtg atgatcgccg
2371921 agaacggtgt ctgccgcgac atcaggtagt tctcgtgcga cccgtaggag gctcccttgc
2371981 cgtcgacgtt gttcttgtac agctgcagtt tcgcggcccc gggcacgctg gcgacatggc
2372041 gggcagcggc ctccatcacg cgttcgcccg ccttgtccca gatcactgcg tccagcgggt
2372101 cggtgcattc gggcgcggag tattccgggt gcgcgtggtc gacatacagc cgcgccccgt
2372161 tggtcaggat catgttggcc gcgccgacct cgtcggcgtc gaccaccggc ggcggcccgg
2372221 ccgagcgact caaatcgaag ccccgggcgt cgcgcagcgg cgattccacc tcgtagtccc
2372281 aacgggtgcg tttggcacgc tgaatgccgg cggcggcggc gtatgccagc accgcctgcg
2372341 tcgaggtgag gatcgggttg gcggtcgggt ccgacggcga ggaaatgccg tactcgacct
2372401 ccgttccgat aatccgctgc atgccgtaga gcctaggccc gccgacgatg cgggccgcgc
2372461 agcgggccgc tgaggaggcg ggcatcaagc aacgcccgcc gacgatgcgg gccgcgcagc
2372521 gggccgctga ggaggcgggc atcaagcaag gcccgccgac ccagaacatc ggagcgggcc
2372581 gcgcaggagg tggacaatca agcagggccc ggcgctaggg taggccggca tgagcctttc
2372641 cgtccgtcgc cccccggcgg cccgagcagc ggccattgtg gaggctgaaa gctggttctt
2372701 gaagcgtggt ctgccctcgg tgctgaccat gcggggccgg tgccgtcggc tgtggccgcg
2372761 gtcggctccg atgttggccg cctgggcggt ggtcgagggc tgcctcatgg ccgtcttctt
2372821 cgtcaccgac ggcggcgaag tcttcatcag cgcgacgccg acgacagcgc aatgggtgat
2372881 cctggcgctg ctcgcggttg ctcttccgct ggcctccctc gtcggctggt tggtgtcgca
2372941 gatatcaagc gggcgtggcc aagcggcggt ggcgaccatg gcggtggcct tcgcggccgc
2373001 atccgacgtc atcgaatccg gcccgatcca gctgttgcgg accgccgtcg tggtgggcct
2373061 ggtgctgctg cagaccggct gcggcgtcgg gtcggtgctt ggctgggcgg tgcggatgac
2373121 gctggagcac cttgcgacgg tcggcacgct ggcggtccgg gccctgccga tcgtgctact
2373181 gacggcattg gtgttcttca acacctatgt ctggctgatg gccgccaaca tcaacggcga
2373241 gcggctgacg ctggcgatgg tttttctgct cgccatcgcc ggggcgttcg tcgtgtccaa
2373301 gacggtggaa cgggtgcgtc cgctgcttcg ctcaacgacg gtgatgcccc aaggcagcca
2373361 aagcctggcc ggcacaccct tcgcgaccat gggcgacccc tctcccggct tccccctcac
2373421 ccgggccgaa cgcctcaacg tggtcttcct gctggcggcc tcgcaactcg tcgagatcct
2373481 ggtagtggcg tcggtcggcg ccgcgatata cctcgttctg ggcatgatca ttctcactcc
2373541 gccgctgctt cgggaatgga cgcactacga ttcgatgacc acgacggtgc tcggcatgac
2373601 gttcccggcg ccggattcgc tcatccgtat gtgtcttttc ctgggcgcgc tgacgttcat
2373661 gtacatcagc gcccgcgcgg tcgacgacgc cgagtaccgc gcgatgttcc tcgaccctct
2373721 gatcgacgac ctgcacaccg cgctgctcgc gcgcaaccgc taccgcaaca acgtggtgac
2373781 cgcgccgtgc gccggtgttg acgccggtca cgtcgatgac taggttcacc ctgatgtcgg
2373841 ctcccgaacg ggtaaccggc ttgtccgggc aacgttacgg ggaagtcctt ctcgtaacac
2373901 ccggggaggc cggtccacag gccaccgttt acaacagctt cccgcttaac gattgtccgg
2373961 ccgagctgtg gtccgcgctc gatccgcaag ccctagccac cgaacacaaa gcggccaccg
2374021 ccctgctcaa cggtccgcgc tattggttga tgaacgccat cgagaaggcg ccccagggcc
2374081 cgccggtgac gaagaccttc ggcgggatcg agatgctcca gcaggccacg gtgctgctgt
2374141 catcgatgaa ccctgcccca tacaccgtca gccaggtcag ccgcaacacg gtctttgtgt
2374201 tcaacgccgg cgaagaggtc tacgaactgc aggaccccaa gggacagcgc tgggtgatgc
2374261 agacgtggag tcaagtggtg gaccccaacc tgtcccgagc cgacctgccc aagctgggtg
2374321 aacggctcaa cctgccagcc gggtggtcct atcatacccg cgtgcttacc agcgagttgc
2374381 gggtcgacac taccaaccgg gaggcccgcg tcctgcaaga cgacctcacc aacagctact
2374441 cgctggtgac cgcctgagcc ctacaggtac tggccgaggt tggactcggt atcaatagcc
2374501 ctgctggccg acgaactctt tccggtgacc agggtgcgga tgtagacgat ccgctccccc
2374561 ttcttgcccg agatccgcgc ccagtcatcg gggttggtgg tgttgggcaa atcctcgttc
2374621 tcggcgaact cgtcgacgat cgaatcgagc agatgctgta tacgcagtcc cggttggccg
2374681 gtctccagca ccgatttgat ggcgttcttc ttggctcggt cgacgacgtt ctggatcatc
2374741 gccccggagt tgaagtcctt gaagtacatg acttccttgt cgccgttggc ataggtgacc
2374801 tccaggaacc ggttgtcgtc gatctcggca tacatccggt cgacaacctt ctcgatcatc
2374861 gccttgatgc aggccgaacg gtcaccgtcg aactcggcga gatcgtcggc gtgcaccggc
2374921 aagaactcgg tcaggtactt cgagtagatg tcctgcgccg cttcggcatc aggccgctcg
2374981 atcttgatct tcacgtcgag gcgcccgggc cgcaggatgg cagggtcgat catgtcctct
2375041 cggttggagg cgccgatcac gatgacattc tcgagtccct ccaccccgtc gatctcgctg
2375101 agcagctgcg ggaccaccgt ggtctcgacg tccgaggaaa cgccggtgcc acgggtgcga
2375161 aagatcgagt ccatctcgtc gaaaaacacg atcaccggag tgccttccga cgccttctcg
2375221 cgggcccgtt ggaagatcag ccggatgtgg cgttccgttt ccccgacgaa tttgttcagc
2375281 agctcggggc ccttgatgtt gaggaagtac gacttcgcct cgtgggcatc gtcgccgcgg
2375341 acctcggcca ttttcttggc caacgagttg gccacagcct tggcgatcaa cgtcttacca
2375401 cagccgggtg ggccatagag caacacaccc ttgggcgggc gcagcgagta ctcccggtac
2375461 aactccttgt gcaggaacgg cagctccacg gcgtcgcgga tctgctcgat ctggcggctc
2375521 agaccgccga tgtcggcgta gctgacgtcc ggcacctctt ccagcaccag gtcttctacc
2375581 tcggctttgg ggatgcgttc gaaggcatag ccggctttgg tgtcgaccag cagcgagtcg
2375641 ccggggcgca gcttgcgcgg ccgggtgtca tcgttgaggg cctcagggag gccgtctggc
2375701 aggtcctcgg cgatcagggg atcagccagc caaacaacgc gttcctcgtc ggcgtggccg
2375761 acgaccagag cccgatgacc gtcggccagg atctcgcgca aggtggatat ctcgccgacc
2375821 gcctcgaatg tgccggcctc cacgacggtc agggcctcgt tgagccggac cgtctgcccc
2375881 ttcttcagcg atgcagcgtc aatattcggt gagcacgtca ggcgcatctt gcgacccgat
2375941 gtgaacacat cgaccgtgtc gtcgtcgtgc gtggccagca ggacgccgta gccactgggc
2376001 ggctgcccca gccggtcaac ttcctcgcgc agcgccagca gttgttgacg ggcttcttta
2376061 agagtttcca ttaatttgga attgcgggca gcaagtgagt cgatacgggc ttcgagttga
2376121 tgtatatcgc gggcagagcg cgtcggggca tgtgatccga cggcgttctc aagttgctcg
2376181 cgcaggaccg cagcctcgcg ccgcagctgt tctaattcgg cggcatcacc actggacagc
2376241 gggctatccc gggggatgcc gaatgcctca gaacgctctg actcacccat gttgcgctcc
2376301 tttcccacgc caggaatcgc gcggcggata ctccaacgct accggcgatc ggcgcttcat
2376361 gttggcagtc gaatgccgat ggaaagtaac aacttgtatc gctggtaatc tcggccccga
2376421 atccagccga tcaaacggac cttgagagga gcactgtgac cgcgaaatcc ctagccacag
2376481 gcgtagtggg cgacgcggcg atcagtgcgg cggccgccgc cgagacttct gctgcattcg
2376541 caagcggccg gtagccgagc gtgtcgctgg atgcgccgaa acatccgtgt aaccctgggc
2376601 gccgccacca tcgtggcggc gttagggctc tccgggtgtt cacaccctga gttcaagcgt
2376661 tcgtcgccgc ctgccccgtc actgccgccc gtcacgtcga gcccgctcga ggccgcgccg
2376721 atcacgcccc tgcccgcacc cgaagccctg atcgatgtgc tgtcccggct cgccgacccg
2376781 gccgtgccgg gcaccaacaa ggtgcagctc atcgagggcg cgacccccga aaacgccgct
2376841 gccctggaca ggttcaccac cgcactgcgt gacgggagct acttgcccat gaccttcgcg
2376901 gccaacgaca tcgcatggtc ggacaacaag ccgtccgacg tgatggccac cgtcgtcgtc
2376961 accactgccc atccggacaa ccgcgagttc acgtttccca tggaattcgt gtccttcaag
2377021 ggcggctggc aattgtctag gcagaccgcg gaaatgctgc tggccatggg taactcaccg
2377081 gattcgactc cgtcggctac cagcccggcg ccggccccat caccgactcc ccctggctga
2377141 gctcccgatg tggattggct ggctggaatt cgacgtgctg ctgggcgacg tgcgctcact
2377201 caagcagaag cggtcggtga cccgccccct ggtcgccgag ttgcagcgca aattcagcgt
2377261 gtcggccgcc gagaccggtt cgcatgatct gtaccggcgg gcgggcatcg gtgtggccgt
2377321 ggtgtccggt gaccgcagcc acgccgtcga tgtcctcgac aacgccgaac gtctggtagc
2377381 cgcacatccg gagttcgagt tgctgtccgt gcgccggggc ctgcaccgca ctgacgacta
2377441 agtggactgg ctcccagctg tgtctcccgc tacccgtcgc gtccctcgcg cttacgacct
2377501 agcggcgccg gagccacagc ccccggcgcc aaccggcgcg ttgctaccag gaacgcggta
2377561 tgcccgcgca tcgaatgctg cggccgaacc gccaacccta cgacgttcca gccccgctgc
2377621 agcgtctccc aggctctcgg ttcggtccag cactgcttgg cccgcagtgc ctccacgatc
2377681 ctcgacagct gagtgacggt ggccacgtag accatcagca ctccgccggc gaccagcagc
2377741 cgcgataccg cgtcgagcac ctcccacggc gccagcatgt cgagcacggc ccgatcaacg
2377801 gatccgtcgg gcagttcgga gtcggcgagg tcgctgacga ccagtcgcca gttgtccggc
2377861 ggctggccgt agcagccgct cacattgcgc cgggcgtgtt cggcatgatc ggcgcgctgt
2377921 tcgtaggaga tcacctgtcc ggccggccca accgcccgca gcaaagacaa ggtcagagca
2377981 ccggatccgg ctcctgcctc cagcacccgc gcgccgggaa atatgtcgcc ctcatgcacg
2378041 atctgggccg catctttggg atagatcacc tgcgggccgc gcggcatcga catgacgtag
2378101 tcgaccagca gcgggcgcag caccaggaac agggcgccgt tgctggattt gaccacgctg
2378161 ccttgctcca acccgatcac cgcgtcgtgg gcgatcgagc cacgatgagt gtggaattcg
2378221 gcaccgggag tcagcgacat ggtgtagcgg cgccccttag cgtcggtgag ctgaacacgt
2378281 tcgccgatgc tgaatgggcc ggttgctgac acgccgtcta gcgtgccagc cgactcgccg
2378341 cgatcggtgc tcggggttgt cggcgcccaa ccctaagctg cggacatggc cgaccagccg
2378401 gacccgccca caccacggcc ggcgttatca ccgtcacggg cgacggactt caagcaatgc
2378461 ccgctgctat accggtttcg cgcgatcgac cggctacccg aggcgacgtc ggcggcgcag
2378521 ttacggggtt cggtggtgca cgccgcgctt gagcagctct atgggctacc cgcggggctg
2378581 cgcagcccgg atactgcgag gtcactggtg cagcgcgctt gggaccagat ggtcgccgcg
2378641 gagcccgaac tggccggcga actggacccc ggacaaccaa cccagctgct ggaggacgcc
2378701 cgcgcgttgg tgtccggcta ctaccggctg gaagacccga ctcggttcga cccgcaatgc
2378761 tgcgaacagc gggtggaggt cgaactggcc gacggaactc tgttgcgcgg ctacatcgac
2378821 cgcattgacg tcgccgccac cggcgagctg cgggtggtcg actacaagac tggcaaggcg
2378881 ccgccggcgg cgcgggcgtt ggcggagttt aaggcgatgt ttcagatgaa gttctacgcg
2378941 gtggcgctat ttcggtcgcg cggcgtgccg cccacccggc tgcggctcat ctatctggcc
2379001 gacggccagc tgctcgacta ttcaccggac cgcgacgagc tattgcgttt cgaaaagacg
2379061 ttgatggcga tttggcgtgc tatccaatcc gcaggcgaga caggcgattt ccgccccaac
2379121 ccatcgcggc tctgcgattg gtgcccgcat caacagcgct gcccggcctt cggcggaaca
2379181 ccaccgccct atccagggtg gcccaccgag ccggcggcat aaacgatcgc gtcgaagtgc
2379241 ggtgtcatag ggccgccgcg gcggcgacga tggcaaaccc gcccaacacc gcgaccgaat
2379301 cctcgagcag cgcgatcggc aggtcgtggc cgccacgggc agccaccagc ctcgtacgtg
2379361 cctgatagcc gcccatggtg ccgagcacgg cgccgataac cccagcgcca agcccgcccc
2379421 accggtagcc ccacgcggtg ccgatgaccg cgccggcgaa cgcgcccaaa atgatccgga
2379481 cagcgaacac cggcgtcacg gtacgcggcg gtgttttggg acgtttgtcg ttaacgagtt
2379541 cggcgaccgc aagaacgctg acgatcacca cggtcacgaa attgcccatc caggatgccc
2379601 aggttccatg caggttgatc cagccgagaa aggcggccca ggagaccacg gccggggccg
2379661 tcagggaacg caacccggcg acgacaccga taagcagcgc cagcagcaga acaaggacat
2379721 gcgtcacagc gatccctcct gacacagacg ttatgggcaa tcaggcccca gcggacgcta
2379781 acacagcgtg ggccccgcca caggatcaga atcggcagaa cctgatgtcc gacgccagaa
2379841 tcgctttggc cccgatcgca gcgagctcat ccatgatgcc gttgacgtcc cggcgcggca
2379901 ccagggcgcg gattgccacc cagtccgggt cggccagcgg ggcgatggtc ggtgactcca
2379961 gccccggcgt gatcgccgtg gccttcttca acgccgagcg cgggcaatcg tagtcgagca
2380021 tcagatactg ctggccgaag accaccccct gcacccgagc gaccagttga tcgcgcgcct
2380081 cggtctggtc ttggccgtcc gtaccggccc gctcgatgag caccgcctcc gaatcgcaca
2380141 gcggctcacc aaaggccacc aggtcgtgct ggctcagcgt gcgacccgac cccaccacat
2380201 cggcgatggc atcggccacc ccgagctgca ccgagatctc cacggcacca tcaagtctga
2380261 tgaccgttgc ttcgattccc ttggtggcca gatctttccg gaccagattc gggtaggcgg
2380321 tggcgatccg catcccggct aggtcggcag tcgtccagtt ccgcccggcg ggagcggcat
2380381 agcggaagct ggacgacccg aagcccagcg ccaggcgttc ccgaacctgt gcaccggaat
2380441 cgcacaccag gtcgcgtccg gtgatcccga agtcgagctc tcccgaaccg acatatatgg
2380501 caatgtcttt gggccgcaag aagaagaact cgacgttgtt gaccggatcg atgacggtca
2380561 agtctttgga atcggtgcgg cggcggtagc cggcctccgc gaggatctcg gtggccggct
2380621 cgctcagcgc acccttgttg ggaaccgcga cccgcagcat gctcacagct ttcgatagac
2380681 gtcgtcgagg gacagtccac gggagatcat cagcacctgc gtccagtaca gcaactggct
2380741 gatctcctcc gccagtgcgt cgttggattc gtgctcggca gccagccaca cctcgccggc
2380801 ctcctcgaga agcttcttac ccagagcatg aaccccgccg tccaatgccg ccaccgtggt
2380861 gctgtcggcc ggccgggtgc gggcacgatc gccgagttcg gcgaacagat cctcgaaggt
2380921 cttcacggcc agcgattgtt gcacgtgtca gccagccaag tcacggtggt ttgacgccac
2380981 acgttcgcca ccgccgcgcc gcgcattagg gcatcctaat ataggttagg ctaccctagt
2381041 tattcctgtg gtcgaaggag gcagccgaac gtgaccttcc cgatgtggtt cgcagttccg
2381101 ccggaagtgc cgtcagcatg gctgtccacc ggcatgggcc ccggtccgct gctggccgcg
2381161 gccagggcgt ggcacgcgct ggccgcgcaa tacaccgaaa ttgcaacgga actcgcaagc
2381221 gtgctcgctg cggtgcaggc aagctcgtgg caggggccca gcgccgaccg gttcgtcgtc
2381281 gcccatcaac cgttccggta ttggctaacc cacgctgcca cggtggccac cgcagcagcc
2381341 gccgcgcacg aaacggccgc cgccgggtat acgtccgcat tggggggcat gcctacgcta
2381401 gccgagttgg cggccaacca tgccatgcac ggcgctctgg tgaccaccaa cttcttcggt
2381461 gtcaacacca tcccgatcgc cctcaacgag gccgactacc tgcgcatgtg gatccaggcc
2381521 gccaccgtca tgagccacta tcaagccgtc gcgcacgaaa gcgtggcggc gacccccagc
2381581 acgccgccgg cgccgcagat agtgaccagt gcggccagct cggcggctag cagcagcttc
2381641 cccgacccga ccaaattgat cctgcagcta ctcaaggatt tcctggagct gctgcgctat
2381701 ctggctgttg agctgctgcc ggggccgctc ggcgacctca tcgcccaggt gttggactgg
2381761 ttcatctcgt tcgtgtccgg tccagtcttc acgtttctcg cctacctggt gctggaccca
2381821 ctgatctatt tcggaccgtt cgccccgctg acgagtccgg tcctgttgcc tgccgggctg
2381881 accgggcttg ccgggctcgg tgcggtatcg gggccggccg gaccaatggt cgaacgtgtg
2381941 cactccgatg gtcccagccg gcaaagctgg cctgcggcca ccggagtcac cctggtgggt
2382001 accaacccgg ctgccctggt taccacgccc gcacccgctc cgaccacgtc cgcggcaccg
2382061 acggcaccgt cgactcccgg atccagtgcc gcccaaggcc tttacgcggt cggtggtccc
2382121 gacggggaag ggttcaaccc gatcgccaag acgacagcac tcgccggtgt taccaccgat
2382181 gccgccgcac ctgccgccaa actgcccggc gaccaagctc agagcagcgc cagcaaagca
2382241 acaagactgc ggcgacgtct ccggcaacac cgcttcgagt ttctggccga cgacggccgc
2382301 ctgaccatgc caaacacacc ggagatggca gacgtcgccg ccggcaaccg tggattggat
2382361 gcgctggggt tcgccggcac gatcccaaaa tcggcgcccg gatcagcgac cgggcttact
2382421 cacctaggcg gcggattcgc cgacgtcctg tcgcagccga tgcttccgca cacgtgggac
2382481 gggtcagatt aaacgttgaa gtacttggct tccggatggt gcaggacgaa cgcgtcggtc
2382541 gactgttcgg gatgcagctg taattcctcg gataacgtca caccgatgcg ttcgggctcc
2382601 agcagcgcca tcatcttggc gcggtcctcc agatccgggc atgcgccgta gccgaaggca
2382661 aagcgagcac cgcggtagcc gagcttgaaa tagtcttctt tcgcctccgg atcctcggcc
2382721 gccatcgccc gatccccgga gaacttgagc tcctcacgga tccgccggtg ccagtactcg
2382781 gccagcgcct cggtgagctg cacgccgata ccgtgcacct ccaggtagtc gcggtaggcg
2382841 ttggacgcga acagctcgtt ggcgaaatcc gcgatcggct gacccatggt caccagctgg
2382901 aacggcagca cgtcaacctc gccacgctcg gcggccagct cccgcgagcg gatgaaatcg
2382961 gcaatgcaca aaaaccgacc gcgctgctgg cgcgggaagt gaaaccggta gcgcaccggg
2383021 gcgtcgggct tgggctcggt gagcaccacg atgtcgttgc cctcggacac cgccgggaaa
2383081 tagccgtaca ccacggcggc gtgcgccaag atgccgtcgg tggacagccg gtccaaccag
2383141 taccgcagcc gcggccggcc ctcggtctcg acgagatctt cgtaggacgg accctcaccg
2383201 ccgcgctggc cgcgtaaacc ccactggccc aaaaacaatg cgcgctcatc gagcagaccg
2383261 gtgtagtcgg ccaccgccag gcccttgacg atccgcgaac cccagaacgg cggcgccggg
2383321 acctcgatgt cggccgcgac atcggagcgt tcgggcacct cgactggttc ttcggcggct
2383381 ttgcgctgtg cggcaatgcg tttggatcgc tggtggcggg ccttacgttc ggcttctttc
2383441 tcacgcgcct taatggcttc cgggctgttt tcgtcgggcg cctcgccgcg cttggcgctc
2383501 atgatggtgt ccatcaactt caggccctcg aaagcgtctc gcgcgtaatg cacttcgccc
2383561 tggtagatct cggccaggtc gttttcgaca tagctgcgcg tcaacgccgc gccgccgagc
2383621 agcaccggga acttttcggc gactccccgg gtgttcatct cctcgaggtt ttccttcatc
2383681 accacggtcg acttcaccag caggcccgac atgccgacca cgtcggcgct cttgtcctcg
2383741 gcgacttcga ggatggtggc gattggctgc ttgatgccga tgttgaccac ttcgtagccg
2383801 ttgttgctca agatgatgtc gaccaggttc ttgccgatgt cgtgcacgtc gcccttgacg
2383861 gtggccagca cgatgcgtcc cttgcccgaa tcgtcgtccg agcgctccat gtgcggttcc
2383921 agatacgcga cggcggcttt cattacctcc gccgactgca gcacgaacgg cagctgcatc
2383981 tggccggagc cgaagagctc gccgaccgtc ttcatgccgg ccagcagatg ttcgttgatg
2384041 atctgaagcg gcggcttttg cgtcatcgcc tcgtcgagat cggcgtccag gccgttgcgc
2384101 tcgccgtcga cgatgcgttg ggccagccgt tcgaacagcg gcagcccagc tagttcagcc
2384161 agtcggtcct ctttcgagga ggccgccgac acgccttcga acagccgcat cagctcctgc
2384221 agcggatcgt agtcctcgcg gcggcggtcg tagaccagat ccagggcgac gttgcgttgc
2384281 tcctcgggaa tccggttcat cggcaggatc ttcgacgcgt gcacgatcgc cgaatccagc
2384341 cccgcttctt ggcattcgtg caggaacacc gagttgagca cctggcgcgc tgcgggattg
2384401 agaccaaacg agatgttgga cagaccaagt gtggtctgca catccgggtg gcgctttttc
2384461 agttcgcgga tcgcctcgat ggtctcgatg ccgtcgcggc gggactcctc ctgaccggtg
2384521 gcgatggtga acgtcaaggt gtcgatgagg atggatgatt cgtcgacgcc ccagttgccg
2384581 gtgatgtcgt tgatcagccg ctcggcgatc tcgaccttct tctgcgcggt gcgggcctgg
2384641 ccctcttcgt cgatggtcag cgcgaccacc gccgcgccgt gctcggcgac cagcgccatg
2384701 gtcttggcaa agcgcgattc cgggccgtcg ccgtcctcgt agttcaccga gttgatcgcg
2384761 caacggccac ccagatgctc caaacccgcc tgcagcaccg cggtttcggt ggagtccagc
2384821 atgatcggca gcgtcgagga cgtggccagc cggctggcca gcgccttcat gtcggccaca
2384881 ccgtcgcggc ccacgtagtc cacacacagg tccagcaggt gggcgccgtc gcgggtctgg
2384941 tccttggcga tgtccaggca cttctggtag tcctcggcga tcatcgcctc acgaaaaccc
2385001 ttggagccgt tggcgttcgt tcgctccccg atcaccagaa ccgaggcgtc ctgggcgaac
2385061 gggattgcgg tgtacagcga cgacaccgac ggctcgtagc tgacctgtcg ctcgggacgc
2385121 ttgatgttcg caaccgcggc agccacttcg cggatatggg ccggggtggt gccgcagcag
2385181 ccaccgacca gcgagagccc gaactcggcg atgaagccgg ccagcgcctc ggccaattcg
2385241 tcgggcagca acggatattc ggcgcccttg gcgcccagca ccggcaaccc ggcgttgggc
2385301 atcaccgaca ccgggatgcg ggcgtgccgg gacaggtggc gcaggtgctc gctcatctcg
2385361 gccggacccg tcgcgcagtt caagccgatc atgtccacac cgagcggctc gacagcggtc
2385421 aacgccgccc cgatctcgct gcccagcagc atggtgccgg tggtctcgac ggtgacgtgg
2385481 gcaaacaccg gaatgtgccg cccggcccgc gtcatcgccc gccgcgaccc caacaccgcc
2385541 gccttcagct gcagtaggtc ctggcaggtt tccaccagga tggcgtcggc tccgccgtcc
2385601 agcatgccca gcgcggcctc ggtgtaggcg tcgcggatca ccgcgtattc ggtgtggccc
2385661 agagtcggca gcttggtgcc cggccccatc gaccccagca cgtagcgctt gcggtcggga
2385721 ctgcccagct cgtcggccac ccggcgtgcg atcgcggtgc ccttctgtga tagatcgcgg
2385781 atcctgtcgg cgatgtcgta gtcgccgagg ttggacaggt tgcagccaaa cgtgttcgtc
2385841 tcgacggcgt cggcgcccgc ttcgaaatag ttgcggtgaa tggtttccag cacgtcaggg
2385901 cgggtttcgt tgaggatctc gttgcagccc tccaggccgc ggaagtcgtc gagcgtgagg
2385961 tccgcggcct gtagttgggt tcccattgca ccgtcgccga ccatcactcg ctgcgacaag
2386021 acgtcgagca gatcggtgtc gtagaggtgc ttgtcggccg cagtcacatg gcaaggatag
2386081 tcggcctatg aaatttcctc agtcgttgac agcgctctgc caggtaccgc gacgtcgcat
2386141 cggtcacagc tgccacaaga gtctcagctg aggcaggcac acaacgtgcc cacctcagcg
2386201 cgacaaagcg tggccatcgc tactagccgg gccgcctcag acgacgtgca cggttcgcat
2386261 cgtcgcccgg gtggacgccg taggctgacc aggtgacccc atcggagggc aacgcaccgc
2386321 tgcccgaact gcacaacacc gtcgtcgtgg ctgcgttcga gggctggaac gacgccggcg
2386381 acgcggccgg cgatgccgtg gcacacctgg cggccagctg gcaagcactg ccgattgtcg
2386441 agatcgatga cgaggcctac tacgactacc aggtcaatcg gccggtcatc cgccaagtcg
2386501 atggggttac ccgggaactg cagtggccgg ccatgcggat ctcgcactgc cgcccacccg
2386561 gcagcgaccg cgacgtggtg ttgatgtgcg gggtggagcc gaatatgcgc tggcgcacgt
2386621 tttgcgacga gttgctggcg gtcatcgaca aactcaacgt ggacaccgtg gtgatcctgg
2386681 gggcgctgct ggccgacacc ccacacaccc ggccggtgcc ggtctcgggc gcggcctact
2386741 ccgcggcgtc ggcgcggcag ttcggccttc aagaaacacg ctacgagggc cccaccggca
2386801 tcgccggcgt cttccaatct gcctgtgtgg gggccggcat cccggcggtg acgttttggg
2386861 cggcggtgcc gcactatgtg tcgcacccac cgaacccgaa ggcgacgatt gcgttgctgc
2386921 gccgggtcga ggacgtgctc gacgtcgagg tgccgttggc ggacctgccc gcacaggccg
2386981 aagcgtggga gcgcgagatc accgagacga tcgccgaaga tcacgagctg gccgagtacg
2387041 tgcagacgct ggaacagcac ggcgacgccg cggtggacat gaacgaggct ctcggcaaca
2387101 tcgacggcga cgcgctggcc gccgagttcg agcgctatct gcgccggcgc cgcccggggt
2387161 tcgggcgcta gagggaggtt gcgctgcggc ggacgacggt gtcagccggg cggcccagga
2387221 tcgccggaat caccctgagt gcccggagcg ccggctttgc cgggattcgt gcctgtcgac
2387281 gtaccaccgc cggcaccagc ctcgccgcgc gcaccgccgc cgccgccggc cccgccctcg
2387341 ccgccgctgc ccatggcgcc gtgggcgccc gagtggccac tgagccagcc gcccgccccg
2387401 cccgcgccac cggcaccgcg ggcacctccg gcgccgccgg tgccaccatc gccaccatcg
2387461 ccgccgtcac cgccgcggcc accgaaggcg ttaccacccc caaaggcgct ggcaacgccg
2387521 ccgccaccgg tcccgccggc ccctccccca ccgcccacac cgccggcacc gccaatgccg
2387581 ccggcaccgc cagccccgcc gtcaccgatc agcagcccgc cggccccgcc agccccgccc
2387641 gcgccgccgg caccacccat gccgccagag gctccggtat tcccgttgcc gccgaagcca
2387701 ccgcggccac cttgggcaaa gcccccagtg aattcgtcgg cgaacccacc tttcccgccg
2387761 tcgccaccga ggccgccggg agcgccggcg cctccgatgc cgccattgcc accggcgccg
2387821 ccggccccgc cgttaccgat caatcccgca ctgttgccgg ccccacggtc ctgaccggcg
2387881 gcacccgccc caccgtgccc gccattgcca tacagcaatc cacccggccc accgggctgg
2387941 cccggcccgc cgttagcgcc gtcgccgatc aacggccggc caacaatgcc tgggtgggcg
2388001 cattgacggc attgagcact tcgtgtgcca acgtggcgtt ggcggtctcg gcggccgcgt
2388061 accacccgcc acccgaggtt agggccgcga caaactgcgc gagatacgcg gccgcctgcg
2388121 cgctgatctg ttggtattcc tgcgcattcg cgccgaacag cgccgcgata gccatcgaca
2388181 cctcgtcggc ggcggtcggc cgccaacgcc gtcgtcgggc ctgccacgag cgcattggcc
2388241 gcgctgatcg ccgaaccgat ccccgccaca tctgcggcgg ccgcggtcag aaagaaggtt
2388301 gcgcgattac gaacgacatg tagtctccaa ccgtttacgg ccgcccggca aggacctaac
2388361 gaaccgttaa gtaggcggcg acagcgcgaa cgctaccgtg accgcactcg cgcgacccca
2388421 cactaggaag cagcactaat gattttctta tcttctccgc agcatcgacg gcgccagccg
2388481 acgttgcggt gtgtgcgggt acgattccgg tggagttgcc gccaccccta gagtgggcga
2388541 ggatcgcaag agcaaattcc gcgccggtag gacaacgata ggaccgccat tacgaagccg
2388601 cccgagactc ctgaattgag cgcggcctca cagcgtgtcg gcgccttcgg cgaagaggcc
2388661 ggctatcaca aaggcctcaa gccccgacaa ctgcagatga tcgggatcgg cggcgcgatt
2388721 gggaccggcc tgttcctcgg cgccggcggc cggcttgcca aggccggacc tgggttgttc
2388781 ttggtgtacg gcgtgtgcgg ggtttttgtc ttcctgatcc tgcgggcgct gggtgagctg
2388841 gtgctgcacc gtccgtcgtc aggctcgttt gtgtcgtatg cacgtgaatt tttcggcgag
2388901 aaggccgctt acgcggtggg ctggatgtac ttcctgcact gggcgatgac gtcgatcgtg
2388961 gacaccaccg cgatcgccac ctacttgcag cgttggacga tcttcacggt ggtcccgcaa
2389021 tggattcttg ccctgatcgc cttgacggtg gtgttgtcga tgaacctgat ttcggtcgaa
2389081 tggttcggcg agctggagtt ttgggccgcg ctgatcaagg ttctcgcgct gatggcgttc
2389141 ctagtggtgg gaaccgtttt tttggccggg cgataccccg tcgacggcca cagcaccgga
2389201 ttgagcttgt ggaacaacca tggcgggctg ttcccgacaa gctggctgcc gctgctgatc
2389261 gttacctcgg gagtggtgtt cgcgtactca gcagtcgaat tggtagggac ggcggccggg
2389321 gagaccgccg agccggagaa gatcatgccg cgggcgatca attcggtggt cgctcgcatc
2389381 gcgatctttt atgtcgggtc ggtggccctg ctagcgctgt tgctgccgta taccgcctac
2389441 aaggccggcg agagcccgtt cgtcacgttc ttttccaaaa tcggtttcca cggtgccggt
2389501 gacttgatga acatcgttgt gcttaccgcc gcgctgtcga gcctgaacgc ggggctgtat
2389561 tcgaccggcc gcgtcatgca ttcgatcgcg atgagcggca gcgccccaag gttcaccgcg
2389621 cgaatgtcga aaagcggtgt gccctacggc gggatcgtgt tgaccgcggt catcaccctg
2389681 ttcggtgtcg cgctgaacgc cttcaagccc ggtgaagcct tcgagattgt gctcaacatg
2389741 tccgcgctgg gcatcatcgc gggttgggcc accatcgtgc tgtgtcagct tcgacttcac
2389801 aagctggcca acgccgggat catgcagcgg ccgcggttcc gcatgccctt ctccccctac
2389861 agcggctacc tcaccttgct cttcttgctt gtcgtgctgg ttacgatggc gtccgacaaa
2389921 ccgatcggca cctggacggt ggcgacactg attattgtca ttccggccct gaccgcaggc
2389981 tggtacctgg tacgcaagcg tgtcatggcc gtcgcccgcg aaaggctggg tcataccggg
2390041 ccatttccgg cggtcgccaa cccgcccgtg aggtcaagag actgatgctt cgaagaggtg
2390101 aatcgatcat ccgcaaccgt tacgccagta agccaccact gtacggaatg gcaatggtct
2390161 tcttggccat ggccgtcgtc gccgtgaccg cgtactttcg catgggctgg tggtcgatca
2390221 tcggttacgc cgccgctgcc attatcggag tgatcgggtt cgcactcgcc ttccgcgacc
2390281 tgtcctgaat cgagcgcgac agaacctcta ggaattctcg agtgattcgg tgtaggcgct
2390341 ggcaaagcgg ccgagcgcgg cgacctcggc atccatctgg ggcatcagct tggcaacggt
2390401 gttgcggatg ggacgttggc ctacccgggt ggacaacaac ggcttgagcc aacggaacag
2390461 ggccacccag cccgggcagt acacgcgatc ttttcggccc tcaatgccgt tgacgaatgc
2390521 ggccgcacac ttgttgaccg acgtggtctt gttcaacggc caagggaggc gcgccagcaa
2390581 ttcggcgaac gcaggcaggt cggccttggt atcgcgaacc aacgcggtgt cgatccacga
2390641 catgtgcgcc gagccgacgc tgacgcccag gtgtgcgacc tcgagtcgca acgcgttggc
2390701 gaagtgctcg ttacccgcct tcgacatgtt gtagggcgcc atcccgggcg gcgccgcgaa
2390761 cgcggcaagc gacgagacga tcaatacgta accgcggcgg tcgatcagcg cgggcaacgt
2390821 cgcccgcacc gtgtggaagt tacccagcaa attgacgtcc aacacccgcc ggaacgcctg
2390881 cgggtcgacc ttcagcacgg agccgtagct ggcgatgccg gcgttggcca cgacgacgtc
2390941 gatgccgccg aatcgttcga cggccgtctc ggctgcggcc tgcatggcgg gcaggtcgcg
2391001 cacgtcggct accacggtga gtaggcggtc gtcgccgccg agttcggcgc ccatcaccgc
2391061 cagctctgat ttgctcaggt cggtcagcac cagtttggcg cccttgttgt gcagccgacg
2391121 ggcgacctca gccccgattc cccgggcagc accggtaatg aagacgacct tgccttgcag
2391181 cgatgtcatg gccgaaaacg taccgccgcg ccggctacag gtccaccccg agcagggcat
2391241 cgatcgccgt cgccaccaac ttcggcgccc cggcatcgtg gccgccgtac tccaccgcat
2391301 cggtgaccca accatccagt gcggcaatcg ctttgggcgt atcgagatcg tcggccaggt
2391361 agcggcgcac ccgagcgaca acgtcaactg cggccggacc ggcgggaagt gcggttgcgg
2391421 tgcgccaacg gtgcagccgg gcggtcgcct cgtcaagcac ctgctggctc cagaaccgat
2391481 cggctcggta gtgtccggcg agcaaaccca gccgaaccgc cgatggctca acgtcctgcg
2391541 cacgcagcgc cgacaccagc acgaggttgc cgcggctctt tgacatcttg tgcccgtccc
2391601 agccgatcat cccggcatgc acgtagtgcc gcgcgaatcg ccgttcgccg ctgacacatt
2391661 cggcgtgcgc agcggtgaac tcgtggtgcg gaaagatcag atcgctacca ccgccctgga
2391721 tgtcgaggcc gcttccgata cgactgagcg cgatggctgc gcactcgaca tgccagcctg
2391781 gccggccagg cccgaacggg gacggccagc tgggctcacc gggccgcgcg gcccgccaca
2391841 acaacgcgtc gagttcgtcg ctcttgccgg ggcgccgcgg atcgccgcca cgttcctcgc
2391901 acagccgcag catggtgtca cggtcatacc ctgactcgta gccgaactgc agggtggcgt
2391961 cagcgcggaa gtagatgtcc tggtactctc ccatttcccg gtctatgaca taggccgccc
2392021 cgcacgccag cattttttcg atgagctcga ccatttcagc aatcgcttcg gtggccccca
2392081 cgtagtcttg cggtggtagc acccgcagcg ccgccatgtc ctcacagaac agggcgacct
2392141 cggcttgggc aaggtcacgc cagtcgacac cgtcgcgatc cgcgcgctca aatagtggat
2392201 cgtcgatgtc ggtgatgttc tggacatagt gcaattcatg accgagatcc agccacagcc
2392261 gatggatcag gtcgaacgtc acataggtgg cagcatggcc cagatgcgtg gcgtcgtagg
2392321 gcgtgatccc gcagacgtac atggtggcct tagatccggg cgccaccgga cggacctgcc
2392381 ggtcggcgct gtcgtacagc cgtagctgcg ggcctcgtcc cggcaacacc ggaaccggtg
2392441 ggcaatacca cgactgcatg tcctcgactc taaacggccc ggtgactcca gcctttctga
2392501 gcagcccgcg cgccgatcag cgccacgcgt cggcgatggc accgagcagg atcggcgcca
2392561 cctcggctcg acacatcagc agatccggca ggtaggggtc cagttggttg tatcgcagcg
2392621 gcgagccatc gagtcgtgac gcgtgcatgc cggcggccaa catcacccca gccggcgccg
2392681 cggaatccca ctcccattgg cctccggcgt gcaggtaggc gtcgacgtag ccgtcaatga
2392741 cggccatcgc tttggcgccc gccgaaccga tcgacaccgg ttggatcgcc agcgtctggc
2392801 ggatgcggtg caggactgcc ggtggccggg tggcgctgac ggcaatccgc aaggtgccag
2392861 gaacgccggc cggcgcggcg ccggaagtca ccgtatcggt gcggtacacc acgttgccac
2392921 gggccggcaa cgccaccgcg gcgtcggtga tctcgggctg gccattggag gaacgccgcc
2392981 acagcgcaat gtgtaccgcc cagtcgtcgc gacccggtgt ggagaactcg cgggtgccat
2393041 ccaacgggtc aataatccac acccgatcgg atttcagccg ggccagatcg tcgtgggcct
2393101 cctcactgag cactgcgtca cccggccgtt cggcctgcag ccgtcgcaac agcagcgagt
2393161 tagcctggcg gtcaccggct tccccgagcg tccatggctg atcgaaaccg atctccgcac
2393221 gcacctggag caacagcttt cccgcgtccg ccgccaggtc ggcggccagc tcggcgtcag
2393281 tcaggtcgtc cgtcagatca ggtgcggcag ggctcaccac ttcagtatcg ccgagctgaa
2393341 cgcaggcatt tgacaatggg gcttcacatc atgatgctct ataattcgca tcttgatgca
2393401 caatagtggg atgcgaacca cggtcagtct cgccgacgac gttgccgctg ccgtgcagcg
2393461 cttgcggaag gaacgctcga tcgggctgag cgaagccgtc aacgagttga tccgtgccgg
2393521 gctcacgaaa cgacaggtcg caaatcggtt ccagcagcag acgtacgaca tgggcgaggg
2393581 aatcgactac tccaacatcg gcgacgcgat cgaaacactg gacggcccgg caagcggcta
2393641 atgctcattg acgcaaacct cctgctctat gccgtcgacg agcgtgccgc gcggcaccgc
2393701 gccgcggttg gctggctttc ggaacaactc aacggctccc gtcgggtcgg cttgccgtgg
2393761 cagagcctgg ccgccttcct gcggatcggg actcatccac gtgcgttccc gcgaccactc
2393821 acacctgccg cggcattcga catcgtcgac ctaaaacgcc ggccagggaa tgggacgatg
2393881 cccattcggc ccgggcatca ccggttggtc cagcagcgat tgcgcgcgtc ggcgcagcgc
2393941 gccgatttcg gctgcggcga ttcgcccggc caacgcctcg gcaagcgggc cgccaagagc
2394001 atcggcgagc ccggcaaccg cctgcagaat ttggtcgtca atcggcttgc cggcccaacc
2394061 ccacagcacg gtgcgcagct tgttctcgac gtgcagacac aatccatggt cgaccccgta
2394121 gacctggccg tcgatgccgc acaggatgtg accgcccttg cggtcggcgt tgttgataag
2394181 cacgtcgaac accgccatcc ggcgcaaccg gatgtcgtcc gcgtgcatca aaacgacctc
2394241 gtcaccggcg tagtcgtagg cccgcagcac cggcagatag cccggccgcg gccggtgggc
2394301 gggaaacagg tcgaccaggt cgggcccggg cagagggtcg gagtcgaccg cgtcgccggg
2394361 ttgctgcacc cagagctgta gcatgcctat gcccgccgga ccgtctcgga tgatggtgtg
2394421 cggcaccagg ttccagccca actgtgtcga caccagatag gcgctgagtt cgcggccggc
2394481 cagcgttccg tcggggaaat cccacaacgg ccgctcgccc gagaccggct tgtagacgca
2394541 atgcaggctg cgcagaccca gcgtggactc acacaaaaag gtggcgttgc tcgccgagcg
2394601 gatccgcccg aggactgtca gctcgccgtc ggccaacacc gcatgctcgt catcccgcag
2394661 ggtcatcgcc agacccgagc agcacatcgc gccggtaacc gttggtgcgc gcacagatgt
2394721 gtccctcggg atccagcggt tcatcgcaga gcgggcacgg cgggcgtccc gcagagatga
2394781 cgcggtagga ccgagtagcg aactgtcggg cggactccgg cgtcagaaat acccgcaccg
2394841 cgtcgggccc ttcctcggtg tcgtcgagca ccacggaagc gtcgaactcc gcgtcggtga
2394901 cggccagcag ttcgaccacc acgctctgcg cctccgaatc ccagcccagc cccatcgtcc
2394961 cgacccgaaa ctcggcatcc accggcatga tcagggggct gaggtcgtcg atctcagtgg
2395021 gttccggggg caccggggtg ccgaaccggc ggttaacctc gaacagcagc gctccgatgc
2395081 gctcggcgag caccgcaacc tgctgcttct ccaggaccac cgacaccacc cgggagtcgt
2395141 gcaccgcctg taggtagaac gtgcggtttc cgggctggcc aacagtcccg gcgacgaaac
2395201 ggtcgggtgt gcggaatacg tgaattgcgc gggccatggc acctccaaaa taccgcgcag
2395261 acgccgttgc cgcgttcttc gtcgacggtc accccacacg ctagtcggtg gaaccgccga
2395321 tcaccgcgtc gccgggtggc accgccgcgt tcggctccgg tgacgcaccc tgggcggaag
2395381 ccgcggcctg caaagccggg gccagccggg cgccggtgtg gttgacgtgc agcacgaacg
2395441 ggcgcagctg ggtgtagcgg acgacactca ccgaacccgg gtcggcggtg attcgctgaa
2395501 agctgtccag atgcataccg aacgcgtctg cgatcaccgc cttgatgaca tcgccatggg
2395561 tgcaggccag ccacagcacg tcgtggccgt gctgatcggc cagccgccgg tcgtgttcgc
2395621 ggacggctgc cacagcgcga gtctgcacct gcgccaaacc ctcaccgccg ggaaacaccg
2395681 ccgcgctggg gtgggcctgg actacccgcc acaacggctc gtcgaccagg tcaccgattt
2395741 ttctgccagt ccattcgccg tagtcgactt cggagaaccg gtcatcgatg agcggctcca
2395801 ggcacagcgc ctcggccagc ggttcgacgg tgcgttgaca ccgcagcatt ggagaagacg
2395861 cgaccgcccg gatcggcagg tcaccaattc gatcgatcaa cccggtggcc tgctcgcgcc
2395921 ccttctcgtc gaggtcgacg ccggaccggc cggccagcac gcccgcggtg ttcgaggtgg
2395981 aacgggcatg gcgtagcaag atgacggtca tgtcgcggct accgtcccgg tagccagcag
2396041 cacgagcatg cccgtcccga cgagcacccg gtagccgacg aaccagtaca tgttgtgtcg
2396101 caccagaaac cgcagcagcc aggccaccgc ggtcagaccg aggacgaacg cgatcagggt
2396161 ggccaccagc aactgcgggc cagtagcgct catgccctcg gttaccgggt ggaatgcgtc
2396221 gggcaacgag aacaacccgg aggcgaacac cgctggaatg gccagcagga atccgaatcg
2396281 ggcggccagt tcacggtcga gtccgagaaa cagtccagcg ctgatggtcg acccggacct
2396341 ggataccccg gggaccagcg ccagggtttg ggcaatacca accaccacgg catcccgcca
2396401 ggtcaaccgc tcaatgtgac gactctggcg ccccacgtat tcggcgagtg cgatcacccc
2396461 ggaaaacacc accagcgcgg tcaccacgac ccacaggttg cggacgcccg accggatgtc
2396521 gtctttgaag aacaggccca gaatgcagat cgggattgtg ccgatgatga cataccagcc
2396581 cagccgataa tcggtgtttc gatgtgcctt cacgaccagg ccgtgcaacc aagcgctcag
2396641 gatgcgcaca atatcgcgcg caaagtagat cactacggcg gcctcggtgc ccaactggct
2396701 cacggcggtg aacgaggcac cggcgtcgcc gctgaagaag atccgcgaca cgatcgccag
2396761 atgtcccgag gacgacaccg gcaggaactc ggtcaaaccc tgggccgcgg ccaacacgat
2396821 gacttgccac caagacatcg ccggagccgc ggtcacgacg acgacggtac ccggttaccg
2396881 gcggccggta gacggatgcg cctaacgcga caccggcgcc gcggatgcca ccgagtcgcg
2396941 cacggccgca gcaaggctgc gttcgtcggt caggtcaatg tcgaccaggc cacggaccgc
2397001 catcgcgacc acatcctcag cctgcggcac cggaccggcc acgcgcggtc gatagatttc
2397061 gacgacgagc gagcgatgct cgatgtggaa ggagaaactg cgtccatcgc cgacttgccc
2397121 atacccgctg gcgaaaattc ccgtcgatat atcttcaaca gcaaactctt cgcgcttgtc
2397181 tgcgagatgc cggtcagcgg tgacggtcat gcccagagaa tacctctgga gtaccatttc
2397241 ccgtgggcga catgacgaga ttgaaagcaa cttgccagat tcggattcgt gagaggttga
2397301 cttcatgttt cgcatccgaa ggctgaccgt tgctaacagg gaataaacca gcagttcaac
2397361 gccgcttcat cggcctgttg atgttgtcag tcctggtcgc aggctgttct tcgaacccgc
2397421 tggctaactt cgcacccggg tatccgccca ccatcgaacc cgcccaaccg gcggtgtcac
2397481 cgcctacttc gcaagacccg gccggtgcag tgcgaccact gagcggccac ccccgggcgg
2397541 cactattcga caacggcacc cgccaattgg tggctctgcg cccgggcgcc gattcggcgg
2397601 cacccgccag catcatggtc ttcgatgacg tgcacgttgc accgcgcgtc atttttctgc
2397661 cgggcccggc agccgcgttg accagcgacg accacggcac ggccttcctt gccgcccgcg
2397721 gcggctactt cgtggccgac ctgtcctccg gtcacaccgc acgagtgaat gtcgctgacg
2397781 cagcgcacac cgatttcacc gcgatcgccc gccgctccga cggcaagctg gtgctgggca
2397841 gcgcagatgg cgccgtctac acgcttgcca agaaccccgc agttgacccg gcgtccggcg
2397901 ccgccaccgt agccagccgg accaagatct tcgcgcgcgt ggatgccctt gtaacacaag
2397961 ggaatacaac cgttgttctg gatcgtggcc agacctcggt gaccacgatc ggcgccgacg
2398021 gtcatgccca gcaggcactg cgcgccggcc aaggtgcgac gaccatggcc gccgatccgc
2398081 tgggccgggt gctgatcgcc gacacccgtg gtggccaact actggtgtac ggcgtcgacc
2398141 cgctgatctt gcgccaggcc tacccggtgc ggcaggctcc gtacgggctg gccggatccc
2398201 gcgaattggc gtgggtgtcc caaaccgcgt ccaacaccgt cattggttac gatctgacca
2398261 ccggaatacc cgtagagaag gtgcgttacc caaccgtgca acaacccaac tcgttggcct
2398321 tcgacgaaac gtcggacacc ttgtacgtgg tgtcgggatc cggtgccggg gtccaggtca
2398381 tcgaacacgc ggcgggcacc cgatgagcag ccgacccgcg gcgcggcgga cctggttgcc
2398441 taccggctgg gattccgaga tgtccgacga gtacgagtgg gcgccattgc gcctaccgcc
2398501 agaagtgacc agggtcagcg cgtccacccg gctgtccatc gaggccgaat accgcggctg
2398561 ggagctagca cgggtacgcc tctataccga cggcagcagg cgggtattgt tgcgccgcaa
2398621 gaaatctcgc tgggcagacg cagaggcgaa ccgccggcca gaccagccgc agctgtggct
2398681 ctgaaggccg gggccagccc gcgcgcagac cgctatcgga tgtatcccct ggtgcgtcgg
2398741 ctgttgttcc tgatcccacc cgagcacgcg cacaagttgg ttttcgccgt gctgcgcggc
2398801 gtggccgccg tggcgccagt gcgccggctc ttgcgccgac tgctgggccc gacggatccg
2398861 gtgctggcca gcacggtgtt cggggtgcgc ttcccggcac cgctcgggct ggccgcgggg
2398921 ttcgacaagg acggcaccgc actatccagt tggggtgcga tggggttcgg ctacgccgag
2398981 atcggcaccg tcaccgctca tccgcagccc ggcaacccgg ccccccgcct gttccggctg
2399041 gccgacgacc gcgccctgct gaaccggatg gggttcaaca atcacggtgc ccgggcactg
2399101 gcgatccgac tcgcgcggca ccgacccgag atcccgatcg gggtgaatat cggcaagacc
2399161 aagaaaacgc cggccggcga cgcggtcaac gactaccggg ccagcgcccg gatggtcggc
2399221 ccgctggcgt cgtatctggt ggtcaacgtc agctctccga acacaccggg gttacgcgat
2399281 ctgcaggcgg tcgaatcgct gcggcccatc ctgtctgccg tccgcgccga gacttcgacg
2399341 ccggtgctgg tgaagatcgc gccggacttg tccgattccg acctcgacga catcgcggac
2399401 ctggccgtcg agctagacct ggccggcatc gtggcaacca acaccacggt gtcacgcgac
2399461 ggcctgacca caccgggggt cgaccggttg ggtcccggcg gcatctcggg gccaccgctg
2399521 gctcagcgcg cggtccaggt gctgcgtcgg ctctatgacc gggtcggtga tcgattggcg
2399581 ctgatcagcg tgggcgggat cgagacggcc gacgacgcgt gggagcgcat cacagcgggc
2399641 gcatcgctgc tacagggcta taccggcttc atctacggcg gggaacggtg ggccaaggac
2399701 atccatgaag gcattgcccg caggctgcat gacggcgggt tcggctcgct gcacgaagcg
2399761 gtcggctcgg caagacgtcg gcaacccagc taaagcgcta acgctgctcg taggtgccga
2399821 agatgaccgc tcgtgcaatc gcgtgctgga acaggttgaa tcccagatat gcaggactcg
2399881 cgtcctcggg gaggtcgagc ttttcgacct tcaccgcgtg taccgcgacg tagtagcgat
2399941 gcaccccatg accgggaggc ggcgccgcac ccacataccg gcgcataccg gcgtcgttga
2400001 ccaatgtcag tgccccgccc ggcagttcgc ggccatcgcc gacaccctcg ggcaactcgg
2400061 tgacgttggc aggcaggttg gccaccgccc agtgccagaa cccggacagg gtgggggcat
2400121 cagggtcgta gacggttacc gcgaagctgc gggtctcgct gggaaatccc gaccacctca
2400181 gctgcggact ggcatccgcc ccgcccgcac ccatgatccc gctgacctgg ggtgtagcca
2400241 gcggctgccc atcggtgatc gaggttgacg tcaggctgaa ggacggcagc ttgggcagcg
2400301 cggcatacgg gtcgggtgaa gttgtcatgg tcagtcctct cgtgtgatcg acgttgcgac
2400361 tagcctcgtt ttcgactagc agtgtgtcag caagtgcgtt agcacctcgg tgccgaaccg
2400421 caacccatcg atgggtaccc gctcgtcgac gccgtggaac aacgaggtga aatccaagtc
2400481 cggcggcaag cgcagcgggc tgaagccaaa gcaccgaata cccaagcgcg cgaacgcctt
2400541 cgcgtccgtt ccaccggaca gcatgtacgg caccgtgcga ccgtctgggt cgaccgccaa
2400601 caccgcggcg ttcatggcgg cgaccagatc accgtcgaag gtggtctcat atgatggcag
2400661 atcgctgacc cactcccggg tcacgtcggg tccgatcagc gcgtcgactt cggcctcgaa
2400721 cgccgcccgg cgacccggaa gcacgcggca gtccacaact gcctccgcgg tcgccgggac
2400781 gacgttggcc ttgtatccgg ccttgagcat cgtagggttc gcggtgtcat gtagcactgc
2400841 cttcaacatg cgggccatcg ggccaagctt gtcgatcgtc ccggccaggt ccggcgagtc
2400901 aaggtcgaag gccagtccgg tctcctctcc gactacggcc aagaactggg cgacggtgtc
2400961 agtgcagacc agcggaaact ggtggcgccc taggcgagcg accgcctcac aaacggcggt
2401021 gaccgcgttc tggtcgtgca ccatcgagcc gtgcccagcc cggccgcgtg ccgtcagccg
2401081 catccactgg atgcccttct cggcggtttc aatcaggtac aggcgacgtt cgccaccatc
2401141 gtgccggggc acggttagcg agaaaccgcc gacttcaccg attgcctcgg tgatgccgtc
2401201 gaacagatcg ggcctattgt cgaccagcca gtgcgacccg tacttgccgc cgtgctcctc
2401261 gtcggcaacg aacgcgaaca ccagatcccg tggcggcacg atagcggcct gacgaaggtg
2401321 gcgggcaacc acaatcatca tgcccaccat gtccttcatg tcgaccgcgc cacgacccca
2401381 gacgtagccg tcttcgatgg cgccggaaaa cgggtgcaca ctccattcgg ccggttcagc
2401441 cggcaccaca tcgagatgcc cgtggatcag cagcgcgccg cgagaactat cggcgcccgc
2401501 cagccgggcg aacacgttgc cgcggccggg cgcaccggat tcaacgtatt caggttggta
2401561 gccgacttcg gcgagctgct cggcgaccca gcgtgcgcac tcggcctcac ccttggtggt
2401621 cccgggttcg ccactgttgg tggtatcgaa ccggattagc ctgctgacga cctgggcgac
2401681 atcatcgctg tggtcgcttg aagccccggt ctcatctgtc acagtcacct ttcctaccac
2401741 tcgtaaccct ggcgagccga tcgcccctgg cgcgccgggc ccgcgtcgtc gccgagctgg
2401801 atttgcttac gtgggctgat tgcctggctc ctcctcaccc cgttacccgg ggcgcatcgt
2401861 cgccgagctc gatttgattg cccggctcct cctcaccccg ttacccgggg cgcatcgtcg
2401921 ccgagctagg ttgggccggt gcggggcaat ccgatagcct tagctgccag ccccggtggt
2401981 tggttggtcc gagtggcgga atggcagacg cgctagcttg aggtgctagt gccctactaa
2402041 tgggcgtggg ggttcaagtc ccccctcgga cacaacttct tagctctata gatcaaaacc
2402101 aagccttgac ctcgtcaagg actaacgtta tgagtttgct cataccaacg atggtcatct
2402161 cgttgatgtc ctaataccta agaactcacc gatcactcga aggtgcggcc agagatctca
2402221 gcctcgaccg cgttcgggtt ctccattccg tgccgaacag ccagtatgtc gatagcctcg
2402281 tcggtcgtcc gataggcaac gtagtacctg aagggccgga ggtagatgtg tcgatagtgc
2402341 ttgaataacg gcgcaaacgc gttcggagcc tgcggaatcc gcttcgtcac ggcatcgaca
2402401 aacaagttgt aaagccgatc gatctgatct ggcgccgcgt ccgcgtagta ggaaaacgcc
2402461 tcgaataggt cgtcttcaac cccgttatgg acgcgcagcc tgcgcgtcat ccgagccggg
2402521 cgcggatccg cttgtcgaag tcatcaatgg tggaccaatg agcatcgtcg gtgtcattgg
2402581 cccgcgcttc gatgagcgcc tggttggcct cgctgatatg catgccctcg gctaggtttc
2402641 cgttgatgtg ctcgacgagc tcaatctgct catcacgcga cagtgcgtcg acgctcgcca
2402701 gcaatgcccg gttgaccacc actcaacgat acccaaggca gccaacgccg gcagcgcagc
2402761 attcggaggc caggctgaac ttcaagctgg caggtgtcat ccgctcagtt gaaagacctc
2402821 aacccgggtc gcaggtggcc aagtcccccc tcggacacca catgtgacgg gtcgaagacg
2402881 aggcacgccg cggacgactt cgagggtaag cagccgtatc ccggggaggc ctgccatgac
2402941 cacttctggg cctatggcag ctagcaaacg tcatgaatgg aagcgccacc atatgccggc
2403001 gatccgacgt tcgagcgttt gcggcgctcg tttcagccag ccgatctact gccggaactg
2403061 caagcggcag gagtgcatta cacaatcgct gtcgaggcgg cggacgatcc ggccgagaat
2403121 gagtctctgt tggccactgc gcgccaccat gattggatag cgcgcgtgat cggttgggtc
2403181 ccactcgccg atccggatga ggttaccgag agctcgacgc acgggcggca ccgcccggac
2403241 gcctcctggc gacgagatct gcggtgcccc ggcctgctgc cgcccgggtg ccaccagcca
2403301 gtcttggtcg taggcttggt aggtcagcag ccggaaatgc gaccgatgaa tccaccaagt
2403361 ggttttctcc ggcggacgcc gacccgcagg tttcgcgacc gccgcgatgc tggtcgcgta
2403421 ttggccgacg aacttgcgtc ctatcgcggc agggaccggt tgctcgtcct cggccttgcc
2403481 cgcggtggcg tccccgtcgg ctgggaagtc gcgtcggcgc taggcgccga attggatgta
2403541 tttctggttc gcaagctcgg cgtgccgcag tggcgcgagc tggcgatggg cgcgttggcc
2403601 agtgggggcg gggtcgtgat gaacgacgac gtggtttcca gcttgcgcat caccgaccag
2403661 caggtgcgtg cggcgatcga cagcgagacg gcagagctgc agcggcgcga gctggcgtat
2403721 cgcggcggac gccctgtcgt cgatccgcgc gccaggatcg tgatcctggt tgacgacggc
2403781 atcgccaccg gcgcgagcat gctggcggcg gtgcgcacca tccgtgccac cggaccggag
2403841 tcgatcgtcg tcgcggtccc ggtcggtccg gccacagcct gccgcgagct cgcggcggaa
2403901 gccgacgacg tggtgtgcgc aaccatgccg gcagcgtttg aggccgtcgg ccaggtctat
2403961 aacgactttc atcaggtcac cgacgacgag gtccgcgagc tgctcgcgac gccaaccaca
2404021 ggcgcagcga cctaacgaga ggattctcgt gaggtgactg ggatggtcag gatgcgtggt
2404081 cgagggtcta gatccggagc tgggcgacaa accacccgat aacctcccac gacgccccta
2404141 ccgaggtcgg tgtcgctgac gaccctactt ggcgctgtcg tcgcttcggt ccgccgatac
2404201 cgccgactcc tcggtcgctt cgctggcctc ctccgatggc tcctcactgc cgatgacacc
2404261 ggcgtcgacg gcttggctct cctcgggggc ttcctccggg tagtcgacgt cggcttcctc
2404321 cgcgacaccc gtttccccag ccccatcagc ttcgtccgcg ccaccttgct ggcgttctcg
2404381 caacgcatcg acgatcagca acgccacacc cagcacgctg gccccgatgc atacccaggc
2404441 cactagctgg ttgctggtga ccaccgcgaa caccaaggcc aggagcccaa tcagggccaa
2404501 gaccagcgca atgatcagca tcggtcatcc tccaaccggc tagcagcgac tgcccaacct
2404561 accaggatct ggctgccgac ctcgaaaact ggcgcgtgtc cggcacgcct ggtggctagt
2404621 ttttgccccg gttgaattga tcgaagccac cggcatccgc attggaatcg accggcgccg
2404681 ccgatccacg ctggccgagt tcctccagct gcgattccag gtaggtcttg agcctggtgc
2404741 ggtactcacg ttcgaaggta cgcagctgct cgaggcggcc ttcaagcacc gcgcgctgct
2404801 ggttgatggt tcccatgatc tcggagtgct tgcgttccgc atcggcctgt aaggcatcgg
2404861 ccttctcctg cgcctggcgc aactgggcct cggatcggga ttgggcatcg gccagcatgg
2404921 catcggcacg ctggcgggcc tcggcgaccg tggcgtcggc ggtgtgtcgg gcctcaccga
2404981 ggatctgctc cgcattggca cgggcatcgg ccagcatctt gtccgactcg gctttggcgg
2405041 tgtttgtaag ccggtcggcg gtgtcttggg ccagactcag cactcgcgcc gccttcaggg
2405101 cctgttcctc gttcatcccc gccgagaccg ccgccggcgc cggcttgccc ggttcgggct
2405161 catacgccgg gattgcctgg gtggcctgcg gcgtaacgcc ggcaccgccg cccgcggcga
2405221 gctcttgatc cagctcgttg atcctctgac gcagatcgga gttctcttcg atcaggcggg
2405281 tcagctcgtt ttccaccagg tcgaggaagg cgtcgacctc atcttcgttg tacccacgtt
2405341 tgccgatagg cggcttactg aacgccacat tgtggacgtc ggcaggtgta agcggcattg
2405401 tttgtcccct cgagttcctg gacggtcaaa cgatctggaa gtgtagaacg gagtggtagc
2405461 cgtggtgcaa ctaccgtcca tcctgtcaca ccagactcgg cggttgccga ttggactaag
2405521 taaataagga ccaatttcaa actctaagac caaataaatc acaatcctta gatttgaaat
2405581 cgtgcgcgcc aaacttgtcc ccaaatcgtg gccgaaccgt ctctcaatcc tcgtcatgca
2405641 cccggccgtg tgaccgcgcc gcggctcagg ccgcagcacc aaacgccagt tgcataccga
2405701 tgaacgcaac cagcagcagc accatgatcg acaggtcgaa ccggaccgcg ccgatcgtga
2405761 gttgcgggat cagccggcgc agcaccttca ccggcggatc agtgatcgac atgatgatct
2405821 ccaagatcac cacggtgaca ccggtgggac gccagtcacg gctgaacgag cggatgaact
2405881 caacgacgac ccgagcgatc agcagcagcc agaagatgaa cagcgcgaac ccaaggatct
2405941 gaaaaaacac caccaacgag agccccgacc ttactgagga ggatgaagaa atgttgcgtc
2406001 gccaccgatg cgggcggcaa cgccagccta ccgactcggg tggcgtgccc acatctcatg
2406061 gcgggccacg ccccgcccag cgtggatgcc caatgggtct acaggcgacc gtcgcgtcta
2406121 ttggtaggcg tagaacccgg tttcggcgat cctgcggcgc tcctcggggg acacatcgac
2406181 gtctgcaggc gagagcagga acaccttggt cgcgaccttg tcgaacgagc cgcgcagcgc
2406241 gaaggccagg ccggccgcga aatcgaccag ccgcttggca tcggcgttgt ccatcgacac
2406301 cagatccatg atgaccgggc tgccgtcgcg gaaccgctca ccgatggtgc gagcctcgct
2406361 gtagtccttg ggccgcagcg tggtgatctt cgagagcgga tggccatcct cgaacatcat
2406421 cgccatccgg cgggggtcca tcgctagcgc gccgcgggtg gagttgcgca gccacgatcc
2406481 gaagcgcggc cgtgtcatct ccgcgcggtc gaactcccgg ggccggaaac gtggttcgtc
2406541 cgcgtacccg ccgcgatatc ccggtggtgg atagtcggcc ggctcaccgc gcaggtcacc
2406601 gcgtgaatcg ctgcgcgcgt cgtcgtagtc gcgcccatcg tagcggccgt agtcgtcgtc
2406661 gaatcggggc cgcgcatacc cgcgcgaggg agcgcggtcg tcgtagtact cgtcgtcgta
2406721 atcctccatg ggagccatac cgaagtaggc cttgaccttg tgcagtgtgc tcattgcgtg
2406781 accccttcta gccctgggag atctgttgtc tgtgatgaag gtgtgactac agtgactatt
2406841 cacggtgacc gtaaccgccg cggacccaat agcgcggtac cgacacgcac acaggtcgaa
2406901 ccatgtttga cggcgacttc aaggtcgttg gacatgcccg ccgacagacc gatcgcgtgc
2406961 gggaacatcg cacgcacccg gttgtgctcc gattgcagcc ggtcaaaggc ctcgtccggg
2407021 tcccaatcca gcggcggaat gcccatcaac ccgaccagtt cgaggccctc tgactcctgc
2407081 acctgcgcgc aaatccggtc tacggcgccg ggcgtcgtgc tgtcgacgcc gccccgggat
2407141 ccgtcaccgt cgaggctgac ctggacgtaa acccgcagcc gctcgccacg acggtgttcg
2407201 gccagcgccg caacaaccgc ccgatccagc gcggtcacca accgcgagct gtccaccgag
2407261 tgagcggtgt gcgcccagcg agccagcgac ccggctttgt tgcgttgaat ccggcccacc
2407321 atgtgccagt gcacaccccc cgagtgaccc aactcggcag ccgccaacaa ccgattaagt
2407381 tcggccatct tggctgaagc ttcctgttcg cgcgattcgc caacggaccg acaacccaat
2407441 cgaaacaaaa tcgcaacatc ggttgctgga aagaatttgg taatcggtag aagttcaatt
2407501 tcgccgacat tgcgacccgc cgcctccgcg gccgccgcaa gtcgcgatcg cattgccgcc
2407561 aacgcatgcg tcaattccga ttcgcggtct ggatacgccg aaagatccgc cgccatcgcg
2407621 gtcattccat ccacaccaac gacgcgaacc gtccggtggg cgcatcgcgg cggtggctga
2407681 acaacgtcgg atcggccacc gtgcagcggg gatcgacgtc gatagactca acacccaaat
2407741 cgcggagctg gcaagcgatt ccggcgcgca ggtcgactcc gggagtgccg gcagcggtgg
2407801 tggtgcggct gcccggcaac gccgcctcga cctcatcggc catcgctgcg ggcacttcgt
2407861 agttgcgacc actgaccgcg ggacccaaca gtgccgagat gtcgcggacc tgggcaccca
2407921 ggctcaacat cacctccagc gcgcgaacca ccacaccgcg ctgcgcgcct gcccgaccgg
2407981 catgaaccgc ggcggcgata ccggcccgtg cgtcggccat cagcaccggc acgcagtcgg
2408041 cggtcacaac cgccagcgcc aatcggggtg tagcggtcac caatccgtcg gtgtcatcga
2408101 gtgccgtatt gcgcggctgg tcgaccagct cgacccgatc cccgtgcacc tggttcatcc
2408161 acaccactcg gttgccgggc agtccgatgg ctgcggccag ccgagcgcgg tttgccgcca
2408221 ccgcggccgg gtcgtcacca acgtggtcgc cgaggttgaa ggtgtcgaac ggtggggccg
2408281 acacaccacc tgcccgggtg gtggtgaccc gacggatgcg aacactcacg ttcccagtat
2408341 cgccgcgggc gatgtgccgc gtactggcga gcaagccgat gctctcagcg gcgcatgaag
2408401 ggcggcacgt cgacatcgtc gtcatcaccg ccgatgctca gggttgcgcc gttggtgtgc
2408461 aacggcacgc tgacggcgtc gaccggctcg aacaaggtcg aggtgagctt gcctgccttg
2408521 gctgactcga tccggtgggc gccgccggtc tcgcccatca ccggcttgcg gccgggaccg
2408581 ctgacgtcga agccggccgc gatcacggtc acccgcacct cgtcaccgag cgaatcgtcg
2408641 atgacggtgc cgaagatgat gttggcatcg gggtgagcgg cgtcttgtac caacgaggcc
2408701 gcctcgttga tctcgaacaa gcccaagtcg ctgccgccgg cgatcgacat cagcacgcct
2408761 tgcgcgccct ccatcgaggc ttccagcaac ggcgagttga tggcgatctc ggccgctttg
2408821 agcgaccggc cttcgccccg ggccgagccg atgcccatca gtgcggtgcc ggcaccggac
2408881 atgatgccct tgacgtcggc gaagtcgacg ttgattagac ccggggtggt aatcaggtcg
2408941 gtgatgccct gcacgccgtt gagcagcacc tcgtcggcgc tacggaaagc atccatcagc
2409001 gataccgcgg catctcccat ctgcagcaac cggtcgttgg gaatcacgat gagggtgtcg
2409061 caactctccc gcagcgccgc gatgccattt tcggcctgat tgctgcgtcg cttgccctcg
2409121 aacgagaacg gccgggtgac cacaccgacg gtcaacgcgc ccagcttgcg ggcgatgctg
2409181 gcgacgacgg gtgccccccc ggtgccggtt ccgcccccct cgccggcggt gacaaacacc
2409241 atgtcggcac cgcgcagcag ctcttcgatc tcgtccttgg cgtcctcggc ggccttacgg
2409301 ccgacctccg gatcggcgcc ggcgcccagc ccgcgggtgg agtcgcggcc gacgtcgagt
2409361 ttgacgtcgg catcgctcat caacaacgcc tgggcgtcgg tgttgatcgc gatgaattcc
2409421 acgcctttga ggccctgctc gatcattcgg ttgacggcgt tgacaccgcc accaccgata
2409481 cccacgacct tgatgacggc caggtagttg tgcggggggg tcatcgttcg gcttcctccc
2409541 tggtggggct cggttcttcg gtgtgtctgc tggcaaactc tcaacctcaa ccataggctt
2409601 agagttatgt caagtagttg ctcgtagtca gaaccgtatg gctacgacgg ttgctaaccg
2409661 tgcaggcgcg ccgatacgcg gcgggcattt tttcggctat ttcacggtcg gcaggtcggg
2409721 gctggacacg tcgtacgttc tgcctggctg ggtcaacagc gccgccagct tttcggcctt
2409781 ctcttcgcag cggtcggtgg ttccccagat caccacgcgg ccatcggcca acgtcagggt
2409841 gatcgaggcc accgacgggg ccgcgatccg ccccacctgg cttgcaactt caggatgcag
2409901 cgcggtcaac acctgcagcg ccgccttggt cgtcggatcg ctaggaccgg gattgtccac
2409961 atcgaaataa ggcaacgccg gcggtggcgg atcggtcgcg aagtcgacgc cgtcgcggtc
2410021 aaaaaggtgc gggccgtccg aaaaatcctt gaccaccacc gggacccgct cgacgatggt
2410081 gatccgcaag gccgacgggt actgccgctg cacccgcgca ctggccaccc gccggatcgt
2410141 ggccactcgg tcagcaacct gttgggtgtc gatctgcagc aacggcgttg ccggccgcac
2410201 tctggcggcg tcgagaacct cctcgcggct caccgccccg atcccgatga tcacgatctc
2410261 gcgggccgac atcgccggcg tgaagtacag cgcgagccca agcccgatcc cgacgacggc
2410321 cagcacgacc gtcgcgagca gcgccttcag ccctcgaaca acacctcggg cggccggttt
2410381 ggcggggttc tgctcactga cgatctgccc gcgggctcgc cgtttggccg cgcggcgagc
2410441 ctgctcgatc gcggtagctc gagcctgcgc ggcgcgacgt tcggcacgtt cgcggcgggc
2410501 gcgccgacgc ggcccttcga attctgggtg ctcggccggt tcgtccttcg attcggtggc
2410561 caacggctcc gtaaccgcct cctcgtcggc ggcgtcgtcg gccacgcgct cgatctgtgg
2410621 gtcctcgttg tgttccgtca tcccagcacc cccggacggc cgggggcgct tcggttggcc
2410681 cggacccgaa gggcggtcag gatttccggg cccagcaagg tcacgtctcc ggcacccatc
2410741 gtgacgatga cgtcgcccgg actagcggcg gcggccactt gctgtgcgac cgccgaaaaa
2410801 tccgggacgt agcgcatcgg cacagtgacg tgctcagcga cgctggctcc gctgacaccg
2410861 gccagcggtt gttcacgagc tccgtagacg tcgagtacga acacctcgtc agcggcattc
2410921 agcgcacgcc caaactcagc agcgaatgcc tttgtccgcg aatacaaatg gggttgaaac
2410981 acaaccatgc agcggccacc gtcgccctgt tcgagcacca tgcgcgccgc cgccagtgtc
2411041 gcgctgatct ccgtcgggtg gtgggcgtag tcatcgaaca cgcgcaccga cgcctttccg
2411101 acgccgcagg tcccaaccag ttcgaatcgt cgccgcactc cttcgaagcc ggccagcccg
2411161 tcgagcacct cgtcggccgg ggcgccgatc tgcaccgcgg ccagcagcgc tcccagcgcg
2411221 ttgagcgcca tgtgtcgccc gggcaccgac agccgcatca cgcggggacc ctgtgctgtg
2411281 gctagttctg aggccaaccg gatatgtgcg accgcgccga ccccctgttg ctgccacgag
2411341 accaacgtgg ctgccatggt ctcacccggc accgacccgt atcgcagcac tcgaattccc
2411401 agctcagtcg cgcgctgagc cagcgcggcc cctccggggt cgtcagtgca caccaccagc
2411461 gcacccccgg ggacaatgcg ctccacgaag gagtcgaaca ccgcaacata cgcctcgacg
2411521 ctgccgtaga agtccaggtg atcggactcg atgttggtga tcaccgcgac gtggggtgtg
2411581 tactgcaaca gcgagccatc gctttcgtcg gcttcggcga cgaaacagtc gccactgccg
2411641 tgatgggcgt tggtaccggc ctcccccagc tcaccgccga ccgcaaagga cgggtcaagc
2411701 ccgcagtgct gcagggcgac gatcagcatg gacgtcgtcg ttgtcttgcc gtgcgtgccg
2411761 gtgaccatca atgtggtgcg cccggccatc aacttggcca gcacggccgg ccgcagcacc
2411821 acgggaatgc cgcggcgcct cgcttcgacg agctcggggt tggttttggg gatggcggca
2411881 tgggtagtga cgaccgccgt ggcgccaccg ggcaacaggt ccagcgacga cgcgtcgtgt
2411941 ccgatccgga tcaacgcgcc ccgcgcccgc agcgcatgca caccgcgcga ctccttggcg
2412001 tctgacccgg agaccagccc gccgcggtcc agcaggattc gggcgatgcc cgacatgcca
2412061 gctccgccga tgccgaccat gtgcacccgc cgcagatcgg gcggcaactg ctcggtgctc
2412121 acgtcgttgt cctggcaccg gccccggtgg cgacggccag cgcggcccgg gccacctggc
2412181 ccgcggcatc gcgatgtccc accctggctg cggccgcggt catcgcggcc agccgcgcgg
2412241 ggtcggtgag cagcccggca acctggcggg ccaccaactc gggggtcagg gcggcgtcgg
2412301 cgaccaccat gccgccgccg gcattgacta ccggcaacgc attcagccgc tgttcaccgt
2412361 tgccgatcgg cagcggcacg tagatggccg gcagaccgac ggcggatact tcggcgaccg
2412421 tcatcgcccc ggcccggcag atcaccagat cggcggcggc gtaggccagc tccatccggt
2412481 ccaaataggg caccgccacg tacggtgggt caccttgagc ccgacggcgc aactccagca
2412541 cgttctgggg tccatgggca tgcagcacgc aaacaccggc ggcggccagg tcggcggcgg
2412601 cgccggacac cgcccggttg agcgagaccg cgccctgcga acccccgaac accagcagca
2412661 cccgcgcgtc gtcggggaag ccgaagtgtg cccgcgcctc ggctcgcagc accgcgcggt
2412721 ccagcgcggc gatcgacgca cggaccggga ccccaaccac ctcggcgcgc cgcagcccgg
2412781 aatccggcac cgcggagagc acccggtccg cggtatgggc gccgacccgg ttggccagtc
2412841 ccgccctggc gttggcttcg tggatcacca ccgggatccg gcgccggcgc cggggcggca
2412901 aaggcaggcc gcgagcggct aggtaagccg gtagcgcgac gtacccaccg aaaccgacga
2412961 cgacgtcggc gtcgacatcg tcgagcacgt cccgggcctc ccggacggcg cgccacaccc
2413021 gcgacggcag ccgggccagg tcgccgccgg gcttgcgcgg catcggcacc gccgtgatca
2413081 gctccaggtg gtagccgcgc tggggcacca gcctggtctc tagtccacgg agggtgccca
2413141 acgcggtaat ccggacgcgc ggatccaacg cgaccaaggc gtcggcgacg gccatggcgg
2413201 gctcgacgtg cccggcggtc ccgccgccgg cgagaacgac cgacacggaa tcagcagacg
2413261 gcgaggaacc acaagacggc gaggcggcat cggcgggccg gggcgccgtt gccccgcgcc
2413321 cgccggccgg ctggctgacc gtgtccttca cccgtaacgc tgaccttcca atgcccgaac
2413381 gcgccgtgtg cgacgctggc ccgcgtaccg ctggccagct ccatgatgca ctgatcgacg
2413441 aaccggcgga tcggccgtgc ggggcgagcc gggtcgcggg ggcaggccca tctgccgggc
2413501 aggctgtccg ggcgccgtgc ggggggtctt ccgcgcgggc tgcgtttggg ccggttgcgg
2413561 gttggcgcgc ttgcggtcac gaaacgcctc gagacgaggg ggcagatacg gctcgggcag
2413621 cggcagccgc agcaaccggt tcaccttgtc gtcgcgccca gcccgcagcg cggccaccgc
2413681 ctccggttcg tggcgagccg cgttggcgat gatgcctatc agcgaaagtg ttgcggccgt
2413741 ggaggttcca ccggcggaga tgagcggcag ctgcaggccg gtgacgggca gcagcccgat
2413801 cacatagccg atgttgatga acgcctgtcc cagcacccac agtgtcgtgg tggcggtcag
2413861 cagccgcagg aacgggtcgg cggaccggct agcgatgcgc atgccggtgt aggcgaacaa
2413921 tccgaatagc cccagcagtc cgagcgcgcc gacgagaccc agctcttcgc cgatgatggc
2413981 gaaaatgaag tcgttgtggg cgttgggcaa gtagttccac ttggccacgc cttggcccag
2414041 accgtcgccg aaaatgccac cttgagccag cgcgaacttt gcctgtcggg cctggtagcc
2414101 ggagtcttgc ggatcgtttt cggggttgag ccacgaccgc acccggtcgg atcggtagcc
2414161 cgcggacacc gccaggatgg cggccgagac gacgaccgcc gccagtgagc tgaggaagac
2414221 gcgcagcggc agccccgcat accacagcag gcccaacaag atgatgccca tcgacacggt
2414281 ctgtccgagg tcgggctggg ccacgatcag cgccagcgca acgacggcgg ccggcaccag
2414341 tggaatcagc atctcgcgca gtgaagcccg ttccatgcgc cgggcggcca gcagatgcgc
2414401 tccccagatg gcgaacgcca tcttagccag ctcagagggc tgcatcgaga agcccgcgac
2414461 cacgaaccag ccgcgcgagc cgttggcctc cttgccgatc cccggcacca gcaccagcac
2414521 cagcatcacg atggtgatcg cgaaaccgga gaaggcgatg cgccgcatga accgcaccga
2414581 catccgcaga cagacatagc cgccgataag acccacaagc gtccacaaga cctgcttgcc
2414641 gaagatcacc caagccgatc cgtcgtcgtc gtaggaccgc accgccgatg ccgacagcac
2414701 catgatcagt ccaagggtgg tcagcaatgc ggcaacggcg atgatgaggt gaaacgaggt
2414761 catcggacgg cccagccagg caccgaaacg ggtgcggggc ctcgccgaac ccgggttaga
2414821 ggcttcttcc gggcccgtcc gctgcccctc gaccggctcg gcccctcgag tctgggagcc
2414881 gtcggtgtcg ctggtgcccc gacgcagcaa ccgggttagc acgctgcccc cgcctaccgg
2414941 atcaccgcgc ggaccgcggt cgcgaatgcc tcgccccggt cggcataacc ggtgaactgg
2415001 tcgaatgagg cgccggccgg tgccagcagc acggtgtcac cgggttgggc catccgccgg
2415061 gccgcggcca ccgcagcggt catcacggca gcgccaacgg tctcaccggc tttgtcatct
2415121 tttgccacat ctagaacaca agcaacagga acctcaacag tcgcaggcat accagtatcc
2415181 tcgcctgcca caacctgaac gactgggaca tcgggcgcgt gtcgtgataa cgcctcggca
2415241 accgctgcgc gatcccggcc gatcagcacc gcaccgacca gccgcgacgc catcgccgca
2415301 acctcggcgt gaagcgacgc gcccttgagc aggccaccgg cgatccatac caccctcggg
2415361 tatgcaagca ccgaagcccg cgcggcgtgc gggttggtgg ccttggagtc gtccacgtag
2415421 gtgatgccgt cggcaacggc caccacctcg gcgcggtgtc ggcccactcg aaacgacgtg
2415481 accgcgtcgg cgatcgcacc ggcgggcacc ccgaccgagc gggccagcgc cgccgcggcc
2415541 agggcgtcaa gcacgccgac cggacctggc accggtatcg acgcgaccgg cagcagcgtc
2415601 aagtcgtcgg agaaggcgcg atcgaccagg tgggcgtcgc gcacgcccag ttcccgcgcg
2415661 gccggctcgc cgagccggaa gccgacccgc acctgcgccg gtgagccgtc cagcagtgcg
2415721 gccgctcggc tgtcatccag cccggccacc gctaccccgc cggtcagcac ccgggccttg
2415781 gccgcggtgt attcggccat cgtggcatgc cagtccaggt ggtcttcggc aatgttgagc
2415841 accgcgccgg cctcgggccg cagcgacggc gcccagtgca gctggaaact ggacaactcc
2415901 acggccagca gctcggccgg ctcgtccagc acatccagca ccgcactgcc gatattgccg
2415961 cacagcacgg cgcggcggcc accggcgatc agcatggcgt gcagcatcga cgtcgtggtg
2416021 gtcttgccgt tggtgccggt caccaccagc cagctgcgcg gcggtccgta gcagcccgct
2416081 gcgtctagcc gccaggctaa ctccacgtca ccccagatcg gcacccccgc cgccgcggcc
2416141 gcggccagta gcggggttgc gggcgagaag ccgggactgg cgaccaccag cgcatacccg
2416201 gttatctgct gcaccgcgtc cgaggaacta acggtcggca gcccacgttc ggcgtgcggt
2416261 cgcagcatga ccggatcgtc gtcgcacacc gtcggcgtcg caccaaaccg agtcagcacc
2416321 gcggccaccg cctgaccggt cacccggcca ccggctacca acacgggcgc acccggcccc
2416381 agagggtcaa gcacgtcagg caccgaccgc ggcaagccac tcaccgtaga acaaggccac
2416441 gcccagaccg caggtgatcg cggtgagcag ccagaaccgg atgatgaccg tggtttcagc
2416501 ccaaccgacc aactcgaaat ggtggtggaa gggcgccatc cgaaacatcc ggcgcccggt
2416561 ggtccggaag gtcaggattt gcaacaccac cgaggtgatc tcggcgacga acagcgcacc
2416621 cagcaccacc gcaaggatct cggtgcggct ggtcaccgac aaccccgcga tgacgccgcc
2416681 caacgccagc gacccagtgt cacccatgaa gatcttggcg ggcgcggcgt tccaccacaa
2416741 aaaaccgatg caggcgccag cggttgcggc cgcgatgagc gccaggtcca gcgggtcgcg
2416801 cacgttgtag cagcccaggc ccggcgccgt cacgcacgcg ttgcggtact gccagaaggt
2416861 gatcagcacg taggcggcgg tgaccatcgc catggtgccg gcggccagcc cgtccaggcc
2416921 atcggtgaag ttgaccgcgt tcgaccaggc gctgacgatg accacgcaga acaacacgaa
2416981 cagcaccggc gccaatgtga cggtggcgat ctcacgcacg taggacagat ccgcgctgcc
2417041 cggtgtcagg ccggcagcat tccggaactg cagcaccagc acgccaaaca gcacggcgga
2417101 ggtgatctgc ccgacggtct tggccgtctt gttcaacccg agattgcgcg acctgcggat
2417161 cttgatcaga tcgtcgatga acccgacgcc gcccaaagcg gtggctaggc ccagcaccaa
2417221 cagacccgat gcgccgatgc cttcaccgtc aaacgccagg cccgctaggt gggcgcccag
2417281 gtagcccgcc cagatgccgg ccagaatcgc caccccgccc atcgacggcg taccgcgctt
2417341 ggtgtggtgg ctgggcgggc catcctcacg gatctggtgg ccgaagccct gcttagtgaa
2417401 caaccggatc agcaccgggg tcagcaagat ggacaccgtc accgctacgg caacggcgat
2417461 aaggatctgc ctcatgggcg cacactcccg catgtgtcgt ctgcgaccaa tgcatcggcc
2417521 accgcaccca gcccggccgc gttcgaggcc ttgaccaaga ccacatcccc gggtcgcagc
2417581 tcggcgcgca gtagtgccag ggcggcgtca ccgtcggcca cattgacggc cgtgcgatcc
2417641 gcaccgtgat cagcagtggc ttcccccgag ccccacgccc cctccaggac cgctccgtgg
2417701 tgcatggcgc tgatcgacct cccggttccc acgacaacga gtcgagacac atctaagcgc
2417761 accgcgagcc ggccgatgcg atcgtgctcg gctatcgcgt cctcacccag ctcggccatc
2417821 tcacccagca ccgcccagct gcggcgggtg gcctcgggtt ggtgcgcgat ccaggccagc
2417881 gcctgcagcc cggcccgcat ggagtcgggg ttggcgttgt aggcgtcgtc gatcaccgtc
2417941 accccgtcgc cgcgggtggt cacctgcatc cgatgccgcg acaccggcgg cgccgcggtc
2418001 agcgcggccg cgacctgttc aacgctggcc ccacactcca gcgcgaccgc cgcggcgcac
2418061 agcgcgttag tgacctggtg gtcgccgcag accccgagtc ggacctcggc ttgggcatcg
2418121 tgggcatgca gcgtaaagcg cggcctggcc aattcgtcca gcgacaccgg ccccgcccaa
2418181 acgtcaccgg tgttgtcccg gctgacccgc accacccggg ccgcggtcag cttggccatc
2418241 gccgccaccg cggggtcatc agcgttgagg acgaccgctc cggaatgcgg aacagcctgc
2418301 ggcagttcgg ctttggtctg tgcgatgacc tcgcgggagc cgaactcacc caaatgtgcg
2418361 gtgccgacgt tgagcacgac tccgatcgac gggggcgcga tctcggcgag cgcggcgatg
2418421 ttgccgtgat ggcgtgccgc catctccaaa atcaggtagt cggtgcgccg cgtcgcgcgc
2418481 agcaccgtcc acgggtgacc cagctcgttg ttgaacgatc cgggcggggc caccacctcc
2418541 cccagcgggg ccagcacggc ggccatcagg tccttggtcg acgtcttgcc cgacgagccg
2418601 gtgatcccga tgatggtgag cccgccggcc accaactgcg cggccaccgc ggtggccagc
2418661 ttggccagcg cggccagcac cgccgccccc gacccgtcgt tgtcgtgctc gaggacgccg
2418721 gccaatacgt tcggcgcggc cactggcgga accacgatgg ccggcacccc caccgggcgg
2418781 gcggccagca cgacggcggc gcccgcggct accgccgacg cggcatggtc gtggccgtcg
2418841 gcgcgcgccc ccggcagggc gaggaacagc ccgcccgggc cgatggcgcg cgagtcgaac
2418901 tcgacggtcc cggtgacgcg gcggtgcgcg gcgtcttgcg gggagatatc ggccactgcg
2418961 cccccgacga tctcggcgat ctgcgcgacg gtcagctcga tcatgcgcgc cgctcgaggg
2419021 cctctagcgc ggcagccagc tccacccggt cgtcgaacgg gcggacccgc ccgccgccgc
2419081 gttgcccggt ctcgtggcct ttgccggcga tgagcaccac gtcgccgggg cgcgcccagg
2419141 caaccgcgtg ccggatcgcg tcccgccggt ctgcgatctc gacgacctgg gcatcaccgc
2419201 cgacttcggc cgccccagcc aggatttcgc ggcggatcgc cgtgggatct tcgtcacgcg
2419261 ggttgtcgtc ggtgacgacc accaagtcgg ccagctgcgc ggctatccgg cccatcgggg
2419321 cccgcttgcc cgggtcacga tcgccgccgg cgccgaacac caccgccagc cggcggtccg
2419381 ggtgcgccaa ggtggtcagc accgaccgca gcgcttccgg tttgtgcgcg tagtcgacca
2419441 gcgcgagaaa gccctggccg cggtcgatct gctcgagccg ccccgggacc cggatctcac
2419501 gcaggcccgg caccgcctgt tccggggaga ccccgacggt gtccagaatc gccagggcga
2419561 ccaggcaatt ggcgacgttg tagcggcccg gtagccggat tccgatgtga tgccctacgc
2419621 cggcggggtc gatggcggtg aattgttgcc cgcccgcgtc cgtgggcgcc acatccgtgg
2419681 cgcgccagtg tgcgggccgg tcggcggcgc tgacggtgat cgcgtcggcg gcccgcgccg
2419741 ccatcgcgcg cccggcgtcg tcgtcgatgc acaccacggc ggtgcgggcg cgcagtgccg
2419801 agtccggatc gaacaatgac gccttggcct cgaagtagtc ggccatgctg gggtggaaat
2419861 ccaggtggtc acgggagaga ttggtgaagg cgccgacggc gaaccgggtg ccgtccaccc
2419921 ggcccagcgc cagcgcgtgg ctggacacct ccatgaccac ggtgtccacc ccgcgttcga
2419981 ccatcgccgc cagcatcgcc tgcagcgtgg gggcctccgg ggtggtcagc gcgctgggaa
2420041 ggtcggcgcc gccgacgcgg atgccgatgg tgccgatcag cccggcgacg cgtccggcag
2420101 cccgtaaccc ggcctcgacc agataggtgg tggtggtctt gccggacgtt ccggtgatcc
2420161 cgataaccgt caaccgctcg gacggatgcc cgtacacggt ggcggccaag ccgccgagca
2420221 cgccgcgggg tgcggggtgc accaacacgg gcacggccgc tcgtccggcg atctcggcga
2420281 ccccggcggg gtcggtgagc accgcgacgg cgccgcgtgc gatcgcgtcg ccgacgtggc
2420341 gggccccgtg ggtggtcgag ccggtcaggg cggcgaacag gtcaccgggt gacacgtcct
2420401 gggcgcgcag cgtgaccccg gtgaccgtcc ggtcctcggt gacggcacgc tgagctggac
2420461 cctcggccag ggccgcgccg acctgatcgg ccagtgcggc caaccgaacg cccacgacgg
2420521 cgttggggcg caagccagtg ggcgcagcct ccacctgtgt cgccacctcc gttcgccgcc
2420581 gcgagatccc tcgggccagc gatgacaccc taccgacagg gcgcgcacac tcacccagtc
2420641 gggttttgcc gcgacacctg gccctcggcg gcggcgccga tccaggtgcc gatgcgccgc
2420701 gcggcggtga aggcggccca ggccagggcg ccaaccagcg ccgcatcggt gtcgagcagg
2420761 gatcgggccg cggcgacgtc gtcgtcggtc acctgatgcg gggccaggcc ggtcagcagg
2420821 gcaagacggg tgggcgcgtg caggtcggcg ggcagctcgg cggtgtgctc gttcgtccag
2420881 cgactgctca tcggcattgg ctcgccgtgc cacgacccca cgacccgcct gaccacctga
2420941 cgagtcggtg gcggcaggtg cggcgcggtg tccaggtggt ggctgagcgc ggcgaacgcg
2421001 gttgctatgg gctcggacgg tgttgcccat gccagatcgt cgggcagcgt tcgcggctcg
2421061 agccggcggg tggagcggcc cggccgatgc tccgcgcgca ccttgcgggc gaacaccagt
2421121 ccaccggcgc ggcgcatgag ctgttgggcg cgcgggcccc ccggcaggaa ggtttcgtcc
2421181 agcagcacca ggaccaggcg tgcgatgaag tggaattgca ccgcggtgcc caggtattcg
2421241 gcggcgacat ccgggccgaa cggtgccggc ggtcccgccg gtgtcccggt tcctgccgcc
2421301 cacgccacat acggcgcgtt cgggtcaccg gcggcaggtg ctgtgccggc caagatcgcc
2421361 gcggcggtgt cggtttggcc tgccgcgtac agcatggtgg tgtgtgcgtc gacgcaccag
2421421 gggcagcgca ggctggccgc gacggcggcg gcgacggctt ccttgcggcc acgcggcacc
2421481 tggcccacca gcagtgtctc gcgcaacgtc gcccagccgg cggtgagcag tccctcgtcc
2421541 ggggacagca tggcgagcgg ctcgggcagc cggccgaact cgcggcgggc ctcggcatag
2421601 acctcggcga ccgcgccgcc ggctcggcgg ggcgcgacgg gctcaatatg gttgacaaat
2421661 ttcatgattc gactccctcc tgggtggtgc cgactctggc cagggccgcg tcgatcgccg
2421721 ttcgcgcccg ctctccggcg ccgtcgtcgt cgagcagcag cagcgcccag ttggcctcca
2421781 tcgcgtaggc gtgcagctcg aacgcgagtt ggcgcacttc gatatccgcc cggatctcgc
2421841 cccggcgttg cgccgtttcg acgtcggccg tgatggcggc gattccggcc cgcccggtcg
2421901 cggcgatgcg gtcgcgcacc gggccaggct gtgagtccac gtcggcggcc gcggccgcga
2421961 aaaagcagcc gccggcacgt cgcgttccag gtatccgacc cacgcatgca tgagggcgcg
2422021 cacccggtcc accccgggcg gcgctgccat cgcgggagcc acgacctcgg cttcgaacac
2422081 gctcacggcg gcctcgacgg tcgccagctg cagctgctcc ttggcgccga aatgccggaa
2422141 caggcccgac ttgctcatgc ccagccgccc ggcaagctcg ccgatggaca gccccgagag
2422201 ccccttcacc gaggcgatat ccatcgcggc gcgcaggatc tgcgcccggg tttggcggcc
2422261 gacgtcggcg ctaggcatgg cttttgacct cccggtcgtc tccggcgaac gcatccacca
2422321 gcggggccga ccggtccagg gcggccagca cctggtcgcg gcccgccgag ggcagcgcga
2422381 gcgccacctc cgcgacaccg gcccggcggt actcgtgcag ggtcgccggg tcgccggccg
2422441 acgagtacac acagacctgg gcggtcgccg gatctcgccc ggcacgctcg aacgcggcgt
2422501 gcagcatcgg caacgcgccc aggagctcgc cgtacccctc gatcggctgc caaccgtcgc
2422561 cgtggcgggc gatcacctcg aacgcccgcg cactgggccg gcacccgaac agcaccggcg
2422621 gcgccacggc cggtttcggc cacgcccacg acggcggcac cgacgcgtgc gtgccctcgt
2422681 agtggaccgg ctctgcggcc catagcgccc gcatggcggc gagcttgtcc accgtcaccg
2422741 cgatccggtc ggcgaacggc acgccgtggt cggcgagctc ctccacgttc cacccgaaac
2422801 ccacccccag cacgaaccgc tcgccggaca tggcgcacag cgaggcgatc tgtttggcca
2422861 gcaggatcgg atcatgcacc gccaccaggc aggccccggt gcccacgcgc agccgcgtcg
2422921 tgaccgccgc ggcggcggcc agcgccacca ccgggtcata gcagcggcga taccagtccg
2422981 gcagctctcc accgggccac ggcgtgctcc tgctgatcgg cacgtgcgtc ttctccggca
2423041 catacaggcc cgcgaagccg cgctcctcgg cccacaccgc gaccaactgc gggggtgggg
2423101 tcaggtcggt gacgaactgc atgagcgaga cgagcatcgg cggcggcttt cattaagcac
2423161 gaacgttcgt gtttaacgat ggtccgcctg gggcgtgctg tcaatgccgg attgcgtgac
2423221 cgctcgctcg gggcccgggt cagccgtcgg cgccgtttgc tccaggggtg ccgaacagca
2423281 caccacggct gccgccggca ccaccacttc cgacgggtat gccgaagccg ccggccccgc
2423341 cgttgccgcc gttgccgatc accacggcgt tgccgccgtt gcccccgtta ccaccgtcgc
2423401 ctttaacgcc tggggggccg tcgccgcctt ccccgccgtt gccgccgcgc ccgccgtcac
2423461 cgatcagcct ggcgttgccg ccggcgccgc cgtcaccggc attacccggc gtgggagcct
2423521 gtccgccgtt gccgccgtcc ccgccgccgc cgccgctgcc gatcagcccg ccgatcccgc
2423581 cggcaccgcc gatgccgccg tccccgccgc tggtgccggc cgacgagaag ccgccgttgc
2423641 cgccgcgccc gccgacgccg ccgttgccgt agaacagccc gccgttgccg ccggccgcgc
2423701 cggcgccgcc ggaccccgca tcggcaaggg tggagctgtt gtcgttgccc ccgttgccgc
2423761 cggcaccgcc gttgccgccg ttgccgatca gcccgacgtg cccaccggcc ccaccggccc
2423821 caccggcccc accggcgccg ccggccccac cgctgttgcc gtggccaccg ttgccgccgt
2423881 gccccccgtc gccgccatta ccgatcaggg cggccccgcc ggcaccaccc gccccaccgc
2423941 tggcgccggt gttgctgagc ccgccgttac cgccgtcacc gccggcgcca ccgttgccga
2424001 tcagcccggc ggcgccgccg gcaccgccgt ttccgccgtg caccccggtc accccgttgc
2424061 ttccgttccc accagccccg ccggccccgc cgtcgccgta cagcagcccg ccgcgccctc
2424121 cgtcaccacc ggcgccgccg gcccccggtg ccccggatgc gctgccgccg gccccgccgg
2424181 ccccgccatg gccccacagc ccggcggccc cgccggcccc gccggcgggg ctgacgcccc
2424241 cggcggtgcc gagcccggcc gcacccccgg gccccccgtt gccgtacagc catccgccat
2424301 tgccgcccgc acctcccgct ccggtggccg cacccgcgcc tccggccccg ccgttgccga
2424361 tcagccccgc cgatccgccg ttgccgccgt tgggattggc ggtgtcaccg gccccgccgt
2424421 taccaccgtt gccgtacaac aagccgccgg gcccaccgtt ttgcccggga cccccgtcgg
2424481 cgccgttgcc gatcaacggg cgccccagca acgtttgggt gggcgcgttg atcgcgttga
2424541 gcagggtctg ctgcacgttg gcggcctcgg cgctggcata cgagcccgcg ccggcgttca
2424601 gggcccgcac gaactggttg tgatacgccg ccagctgagc gctcaacgtc tgatagccct
2424661 gggcgtgcga cccgaacaac gccgagatcg ccaccgacac ctcgtcggcg ccggccgcca
2424721 ggattcccat cgtggggcct gccgccgccg cactggcggc gctgatcgac gacccgatgt
2424781 tcgccaaatc cgtggcggcc gctgccatca cctccggcgc cgcaatcaca aacgacatcc
2424841 cgcacctccg accagctcag cacaacttca cgaatcccag acctgcgaca ccgtcggcag
2424901 ggctttcgat cctataacaa tctgaaaaca ggatgtcgca ctttccttaa aagagcttcc
2424961 gccaacccga tcgtcagcgc gcacatgttg cgcaaaagtt gttggagccg aaacgaaccg
2425021 gcgcgcgccg ttaccggcgc cgccgcccta ggtggcctgc aagaccaaag gaggcccggg
2425081 atcgggtgac agcgggacgt tttcgcgctg catcagccag cccgcgatgt tgtggaacag
2425141 cggggcggcc gagtgcccag gcgcgccgtc ggagttgcgc gccgggttgt ccaacatgat
2425201 gccgatcacg tagcggggat tgtcggcagt ggcgattccg gcgaaggtga tccaatacac
2425261 gtcgtcgaag tagcagccgc agccagggtt gatctgctgc gcggtaccgg tcttgccggc
2425321 catctgatag ccgggcaccc cggccgtcgg cccggtaccc tgctggtagc ccatcggatc
2425381 gcgttgcacc acggcacgca gcatctggcg cacggtctgg gcggtctgcg ccgacaccac
2425441 gcgaatgtcg tcggggcgcg gttcttcggt tcggctgccg tcgggtgcga cggtggcctt
2425501 gataatgcgt gggggtaccc gcactccatc gttggcgatg gcctggtaca tgccggtcat
2425561 ctgcagcaaa gtcatcgaaa gaccttggcc aataggaaga ttagcgaacg tactgcccga
2425621 ccactggtcg attggcggca ccagtccggc gctctcaccg ggcaggccca cgccggtgcg
2425681 ctgtcccaac ccgaacttgc ggagcatatc gtaatagcgt tccggtccga cacgttggga
2425741 aagcatcagc gtgccgacgt tggaggactt tccgaacacc cccgtggtgg tatagggcat
2425801 cacgccgtgc tcccaagcgt catgcacggt aacaccgccc atctggatcg agccaggcac
2425861 ctgtagcacc tcgtcggggc tgctcaaccc gtgctcgatg accgcggacg cggcgacgat
2425921 cttgttcacc gagcccggct cgaagggcga cgacaccgcc gggttgccca actgcttgtc
2425981 gccctggcgc ccgatgtctt gcgacgggtc gaaggtgttg tcgttggcca tcgcgagcac
2426041 ctcgccggtc ttggcgtcca ggacgacggc cgagacgttg tgagcccccg ataggttctt
2426101 ggcctgctgc acctgctgct gcacgtagaa ctggatgtcg ttgtcgaggg tgagcacgac
2426161 ggtggaaccg tggaccgcct tgtgccgatt ccggtagctg ccggggatga cgacgccgtc
2426221 tgacccacgg tcgtaggtga ccgatccgtc ggttccggcc agcaccgcat ccagggagtc
2426281 ctccagaccc agcagcccat gaccatccca gtcgatgcca ccgacgacgt ttgccgccag
2426341 cgacccaccc gggtactgac gcagatcctg tctttccgca ccgacctcgg gatacttcgc
2426401 gcagatcgcg ctggcgacag ccgggtcgac cgcacgcgcc aagtagacga aggtctcgtc
2426461 gctttgcagc ttcttcagca cggccgcggc atctggcttg ttgttcagct tgccggcgac
2426521 ctcctgggcg atatcgcgca ggcgctgctg cgggtcgggt gcagccgacg tcttcttcct
2426581 ggcctcttcc aattgccgcc gaatccgctt cggctggaac gtcagggcac gcgcctcgat
2426641 ggtgaacgcg agccggtcat tgttgcggtc gacgatgctg ccgcgagccg ctggctggac
2426701 gtcggtgacc ttgagttggc cggccgcctg cgcacgcagg cccgcggcat gtgatacctg
2426761 cagaaagaac aattgtgttg ccgcgaccaa catcaacacc aagatgaccg cgtttccggt
2426821 ccgatgccga aagacgaacg acgcaccgcg cgtcccgacg tccaccacct gccgggtgcg
2426881 cctcgcacga gtcgagcgac ccgcgggtgc gacgtctgac cgtgtcgcag ggcgggattt
2426941 cgtggcttcc tgggcttgcc gggctttctg cgttttgccg ggccgtttgc gttgcccaac
2427001 ctcctgggct cccggtggcc ggcgcaaacc gcgcgccggt cgcgtcgact gcgactgact
2427061 ggcccgcctg ggggcggcgc ggctcacctg ggagcccccg gcgccgttgg caccggcgcc
2427121 gtgacgggac cgaactgttc gccgttggcc ggcactggag cgggtggtgc caccatgggt
2427181 tgcgacccac ccgacagccc gggcgtcgca gccaccggtg ctggtccagg gagcccggcc
2427241 gggggcgccg cacccacctg gagcggcacc ggattttccg ctggtgccgg ggatggcact
2427301 gcgccgagcg gaggagccgg catcggaccc ggcgccccag gtatcggcac cggaccgggc
2427361 agctgcgggc cggcctgggt gggcaggtgg gttgcgccgc ccagcgtcgc tgtgccgtct
2427421 ggggtacgca ccagcacctc cgggccagac cgggcgggcg gagcgggatc atcggggcct
2427481 ggtgtcaccc ggaccggcac ctcgaggggc accgccgcgg gtttcggggg cggcggcgga
2427541 tcttcgggca acttcgtgtt cagcggcggc ggtggaactc cgtcagccgg cttgggtgta
2427601 ccgaccacca cccaattgcc gtccggatcc tgaaccaggt gggcggtatc cctcgtcggg
2427661 atcatgccct ggcgacgagc cgcctcggcc agcgccggcg ccgacgcagc ctcgcgtacg
2427721 tcgcgttcca gcgcttcctt gtgctgctgc agcatccggg tccgctcccg ggcgttgctc
2427781 agctggtagg acctctcggc ggcatcggtg gacaaccaca gtgtgaggcc tagtccgacg
2427841 ccgagcgaac cgataaccag caccacaaac ggaaccttgt ttgccaacgt gcgcggccgc
2427901 aggtcgatcg acgtgagccg ggcggcgaga cgctccatcg gcgtaggacg gaccagcttg
2427961 ggcgccttgg cttttcgggc cttggcccgc gccttggcct ggctggtgtt ctttgcgggg
2428021 gccggccggt cgaacgggct gagcatcggg ctggtttgcg gtccagggcg cgacacccgg
2428081 gcctgccggc cgggtgccga ggtcttgccg gcacggctcc ggatgcggcg cgacggcgcc
2428141 gagttcgtag tcgttcgcct cgtcgccgcg gcaggactgt cggctctcct gcgacgatcg
2428201 ctgctgcggc ttttcggtgc ctcacgcttg gccctcatga atcacccttc tcggttgccc
2428261 attgctgcga ttgcgcccgg tgctcgactc gttgcagggc ccgcaaccgc actggagtac
2428321 tgcggggatt gcgttcgatc tcagccacac tcgctcgttc ggcgccgtgc gttaacgaac
2428381 ggaatcgcgg ctcatggccg ggaagttcga ccggaagtcc cgcaggggtg gccgacgcga
2428441 ctgcctcggc gaacacccgt ttgacgatcc tgtcctctag cgactggtag gccagcaccg
2428501 cgatgcgccc accgatagcg agggcatcca gcgcggcagg aacggccgtg cgcagcgatt
2428561 ccagctcatc gttgaccgcg atgcgcagcg cctggaatgt tcgcttggct ggatgcccgc
2428621 cgacacgccg ggccggagct ggaatcgcct ggtacagcag ggcaaccagt tcggcggtcg
2428681 aggtgaacgg ggtttttgcg cgtcggcgga cgataccggc agcgatgcgc cgagcaaacc
2428741 gctcctctcc gtagcgacgc aggatgtcgg ctagtgccgc ctcgtcgtaa gtgttgacaa
2428801 tgtcagctgc ggtcaacggc gtcgtcgggt ccatccgcat gtccaatggc gcgtccgtgg
2428861 cgtaggcgaa gccccgctcg gcgcggtcga gctgcatgga tgagacgccg agatcgaaca
2428921 ggattccgtc gactgatccc actgcggcat aaccggattc agccagcgct gcgcccagac
2428981 agtcatagcg ggtgtgcacc agggtaagtc ggtcagcgaa tcgcaccagc cgagaccgcg
2429041 cgacgtccag agcggttggg tcacggtcga gcccgatcag gcgcagaccc ggcaatccct
2429101 ccaaaaaccg ctccgcatgc ccgcccgcgc cgatggtcgc gtcgagaagg accgcctgcg
2429161 agccgtctgg atagtagcgg gttagtgcgg gggtaagcag ttcgaagcaa cgttgcgcca
2429221 ataccggcac atgaccgaaa ccggttggcc ccgaacctgg atcagccacc gtgatacctc
2429281 cccaggtctg gcaagccgta cttcgggacg cggctattcc aggcgccgcc cctgcaccga
2429341 ggtccctgtc cgaagacacg aacctggcgt tggggaagta cgccagggtc gcttcgggca
2429401 gagaccacgg tgcacgggtt tgcacctcag aagatgtcac cgagtgcttc atcgctggcc
2429461 gcggagaagt tctcttcatg gatttgttgg tagttctgcc aggcttgcgc atcccagatc
2429521 tcgagatagt cgaccgcgcc gatcaccaca cagtccttgg aaaggcttgc gtagcggcgg
2429581 tggtcggccg acaaggtgat ccggccttga ctgtcgggat gctgttcgtc ggtaccggcg
2429641 gcgagattac gtaggaacgc tctcgcctcg gggttgcttc gtggcgcctt gctggcccgg
2429701 cgcgccagct gctcgaacgc cgcccgcggg taaacggcca ggctgtgatc ttggctcttg
2429761 gtgaccatca acccccctgc caacgcgtcg cgaaacttgg ccggcagcgt cagccgcccc
2429821 ttgtcgtcga gtttgggcgt gtaggtgccg agaaacatgg ggcacctccc tgccaaatcc
2429881 atctcaccca aacacctcag ccaccatacc ccacaatccc ccactttgcc ccataactgg
2429941 ggtatcaaag cggcgttttg ccgtctctgt accactgaag cgcgcggcta gcccggctac
2430001 gacctcagaa aaccgcatgt cgccgggcaa atgggtggca agtggggcca agtggggcac
2430061 aactggggct caaaccggac tcaatatcgc cgacagccgg tgacgacccg gctgggtgaa
2430121 ccgccccggt gagtccggag actctctgat ctgagacctc agccggcggc tggtctctgg
2430181 cgttgagcgt agtaggcagc ctcgagttcg accggcggga cgtcgccgca gtactggtag
2430241 aggcggcgat ggttgaacca gtcgacccag cgcgcggtgg ccaactcgac atcctcgatg
2430301 gaccgccagg gcttgccggg tttgatcagc tcggtcttgt ataggccgtt gatcgtctcg
2430361 gctagtgcat tgtcatagga gcttccgacc gctccgaccg acggttggat gcctgcctcg
2430421 gcgagccgct cgctgaaccg gatcgatgtg tactgagatc ccctatccgt atggtggata
2430481 acgtctttca ggtcgagtac gccttcttgt tggcgggtcc agatggcttg ctcgatcgcg
2430541 tcgaggacca tggaggtggc catcgtggaa gcgacccgcc agcccaggat cctgcgagcg
2430601 taggcgtcgg tgacaaaggc cacgtaggcg aaccctgccc aggtcgacac ataggtgagg
2430661 tctgctaccc acagccggtt aggtgctggt ggtccgaagc ggcgctggac gagatcggcg
2430721 ggacgggctg tggccggatc agcgatcgtg gtcctgcggg ctttgccgcg ggtggtcccg
2430781 gacaggccga gtttggtcat cagccgttcg acggtgcatc tggccacctc gatgccctca
2430841 cggttcaggg ttagccacac tttgcgggca ccgtaaacac cgtagttggc ggcgtggacg
2430901 cggctgatgt gctccttgag ttcgccatcg cgcagctcgc ggcggctggg ctcccggttg
2430961 atgtggtcgt agtaggtcga tggggcgatc ggcacaccca gctcggtcag ctgtgtgcag
2431021 atcgactcga caccccaccg caaaccatcg gggccctcgc ggtggccctg atgatcggcg
2431081 atgaaccggg taattagcgt gctggccggt cgagctcggc cgcgaagaaa gccgacgcgg
2431141 tctttaaaat cgcgttcgcc cttcgcaatt cggcgttgtc ccgccgcaag cgcttcagct
2431201 cagcggattc ttcggtcgtg gtcccgggcc gtgcgccggc atcgacctgc gcctggcgca
2431261 cccacttacg caccgtctcc gcgcagccaa caccaagtag acgggcgacc tcactgatcg
2431321 ctgcccactc cgaatcgtgc tgaccgcgga tctctgcgac catccgcacc gcccgctcac
2431381 gcagctccgg cgggtacctc ctcgatgaac cacctgacat gaccccatcc tttccaagaa
2431441 ctggagtctc cggacatgcc ggggcggttc aggggcttcc cgagactgcg attcccaaac
2431501 gatgacgccc aaacaaaaag cgggaccgcc gatggctgcc ccgctgccgc tggttgcgtt
2431561 cggcttactc gtcgaagcgg cgccggaacc gatcttccat acggctggtg aatgagcccc
2431621 cggccccctt ggtacgacgc tggcgcgaag ccccagcagc cgatccgcca cgatccatcc
2431681 tgccggacaa ccgaggaccg gtgatggcat acaccacacc accgaacatc acgacaaaac
2431741 cgaaaacgct gagtatcggg aaacttccga tcatggtctc tttgaacgcc acgccggaaa
2431801 ccaacatccc cagaccgatg atgaacaacg ccgcgccctg caggcgccgc cgcgcggtcg
2431861 gtgcgcggaa gcccccgcca cggacactcg atgcgaactt gggatcttcg gcgtagagag
2431921 cgctctcgat ctggtcaagc atccgctgct catgatcgga gagtggcatg cgtccctcct
2431981 tgccgacaga ctgtcacgta ataccgataa cacgcggatg cccattgcgc gggcaactaa
2432041 ctcagatgat acgaggtcaa tctgcgccgt accactggtt cgcgggcgat tctatcccgg
2432101 cggcgccgca gcgacgagct gagcggaaac ggccatacgc tacaagcccc gtccagcgcg
2432161 ggcggcctca tcggcttgtc cgatactggt gcgcaagcac gcatcggttc atcacatgag
2432221 gaggacaccg cgcgttggcg atattcctca tcgatctgcc gcccagcgat atggagcgcc
2432281 gcctcggtga tgccctgacg gtgtatgtcg acgcgatgcg ctaccccagg ggcaccgaga
2432341 ctttgcgcgc cccaatgtgg ctggagcaca tccggcggcg cggctggcag gcggtcgcgg
2432401 ccgtcgaggt aacggcagcc gaacaggccg aggccgccga caccacggcg ctgccgtcgg
2432461 ccgccgaact gagcaacgcg ccaatgctcg gagtggcgta cggctatccc ggggcgcccg
2432521 gccagtggtg gcaacagcag gtggtactgg gcttgcaacg cagcggcttt ccgcgcctag
2432581 cgatcgcccg actgatgacc agctacttcg agttgactga attgcacatc cttccccgcg
2432641 ctcaaggccg tggcctcggg gaggcgttgg cccgccgact gctagccggt cgcgacgagg
2432701 acaacgtcct gctctccaca ccggagacca acggtgagga caatcgggcg tggcggttgt
2432761 accgccggtt gggcttcacc gacatcatcc gcggctacca cttcgccggt gacccccgag
2432821 cattcgccat cctgggtcgc acgctaccgc tctaacccgc gcccgacagc ttgccgacgc
2432881 ggcatgcccg gtctggcacg atgacctggt gcgcgctagc tatgccccac cgtcatccca
2432941 aggatcgcga gtggcaagga cccgacggcg cggcatgctg gccatcgcga tgttgctgat
2433001 gctggtgcct ctggctaccg gatgcctgcg ggtccgagcc tcgatcacca tctcgccgga
2433061 tgacctggtg tccggggaga tcatcgccgc ggccaagccg aaaaacagca aagacaccgg
2433121 ccctgcgctc gatggcgatg tgccgttcag ccagaaggtt gcggtctcga actacgacag
2433181 cgacggctac gtggggtcgc aagcagtgtt ttccgatttg acctttgccg agctgcccca
2433241 gttggccaat atgaactccg acgccgccgg agtgaacctg tcactgcgcc gaaacggcaa
2433301 catcgtgatc ctggaaggcc gagcggatct gacatcggta tccgatcccg acgccgacgt
2433361 cgagttgacc gtcgccttcc ccgcagcagt gacttccacc aacggcgacc gcatcgagcc
2433421 cgaggtagtg cagtggaagc tcaagccggg cgtggtgagc acgatgagcg cacaggctcg
2433481 ttataccgat cccaacaccc ggtcgttcac cggagccggc atctggctgg gcatcgccgc
2433541 gttcgcggcc gccggtgtgg tggccgtgct ggcgtggatc gaccgggacc gctccccacg
2433601 gttgaccgct tcgggcgacc cgccaaccag ctagtccggc ttgcccggct cggcaggtga
2433661 ccagtaggca agcatttccg cgaaggtctc gaaagccgcg gccgaaacgc catacgtcgc
2433721 ctcgagatgg atgcttagcg gaaaacccag atcggcgacg ccgtctagca cacgcttgta
2433781 caagtcgacc atgagccggc gccgccgtgc gggttcactg ccggccaact tctgcacgaa
2433841 cgcctgctcg tcggccaccg cggcgtttcc cgggtcctgg atcagccagt tgatcaggcc
2433901 gatgcgggtc tcgaccttcg ggacaaagcc gaacgacagc agaatctcgg gtcggtgttc
2433961 ggtggtcctg gcgaactcgc gcaggaagcc cacgatcgcg tcggaataca acagctgggt
2434021 catgccgtag gttgcgcccc gactgcactt gaaattgagc cggccctgct cgccgtctcg
2434081 ggtggggatc acgatcacac cacggttggc caccagctgg cgatacagcg acagggcatc
2434141 cgtcggcgcg actccggagc cctcgccgtc ctgcatcgtg cgcggtacac cgacgaatac
2434201 gatgccctcc atgccggcat cggacagatc gaccagccgc cggtgcaacg atggctcgtc
2434261 catgaacgcg gttacctgcg tacacaggcc atggactccc gccaactccg gtttgatgat
2434321 cgaccagaaa tcgagtacat ccagcttcgg ctgcatcggg atgggcctat cgtcatcctc
2434381 ggcgatcatc cccggcatca ttacgtgccg tatccggccg tcaagcccgg atgcagccga
2434441 gtactgcacc accttgcgag catcttcgat tgcccgctcc ttgccaccct cgaggttcgg
2434501 tggcaccagc tccagcgcga tcgtgttgag ggtcacacgg ctcctcttcg tcaaacgagt
2434561 acttccatgg ccgccaatgg ggccaccggt gggccgcgcc gcgtcgcgca aatcgccatc
2434621 ctgggccggg ccggaccagc caacccaagg gcgctgaaga cagcataaac acgaaatagt
2434681 cagttagtcg aagcaacttg tgtggtttcc gcgagcccac ccgccgaatc atcgatagcg
2434741 gccactcgcg ccggcgcgga atacactgtc gggccatagg cacgccaaat gagaaagggg
2434801 cgccgcgctg agcctgaatg caccggcagc accggcagcg gtccagttgg ccggcgccat
2434861 caccgaccag ctgcggaggt atttgcacgg ccgccgccgt gcggccgccc acatgggcag
2434921 tgactacgac ggcctgatcg ccgacctgga ggatttcgtt ctcggcgggg gcaagcgcct
2434981 acgaccgctc ttcgcctatt ggggctggca cgccgttgcc agtcgggaac ccgatcctga
2435041 tgtgctgctg ctgttttccg cgctggaact gctgcacgcc tgggcgctgg tccacgacga
2435101 cctgatcgac cgttccgcca cccgccgggg ccgcccgacc gcccagctgc gctacgcggc
2435161 gctgcaccgc gatcgggact ggcgggggtc accggaccag ttcggcatgt cggcggccat
2435221 cctgctcggc gacctcgcac aggtctgggc tgacgacatc gtctcgaagg tctgccagtc
2435281 cgccctggca cccgatgccc agcggcgagt gcatcgggtg tgggccgata tccgcaacga
2435341 ggtgctgggc gggcaatacc tcgacatcgt cgcagaggcc agtgccgccg agtcgatcga
2435401 gtcggcgatg aacgtcgcga cgctcaagac cgcctgctac acggtatcgc gaccgctaca
2435461 gcttgggacg gccgccgcgg ccgacagatc cgacgtagcg gccatcttcg agcatttcgg
2435521 agcggacctc ggcgtagcgt ttcagttgcg cgacgacgtg cttggcgtgt ttggcgaccc
2435581 agccgtgacg ggcaagccgt ccggtgacga cctaaagtcg ggcaagcgta ccgtgctggt
2435641 agccgaagcg gtggaattgg cggacaggtc agaccccttg gcggccaaac tattacggac
2435701 ctcgattggc acccgattga ctgatgcgca ggtacgtgaa ctgcgcacgg tcatcgaggc
2435761 agtgggcgcg cgcgccgccg cggagagccg catcgccgcg ctcacccagc gagcactggc
2435821 caccctggcg tccgcaccca tcaacgcaac agccaaggcc gggctgtccg aactggccat
2435881 gatggctgcg aaccggtccg cctaaccgat gactactccg agccatgctc cagcggttga
2435941 tttggctaca gcgaaagatg ctgttgtcca acacctttcg cgacttttcg agttcactac
2436001 cggtccgcag ggcggaccgg cgcggctggg cttcgccggc gcggtgctga tcaccgcagg
2436061 cgggctggga gccggcagcg tccgccaaca tgacccgctg ctggagtcga ttcacatgtc
2436121 ctggctgcgc ttcggccacg gactcgtgct gtcgtcgatt ctgttgtgga caggtgtggg
2436181 tgtgatgctg cttgcgtggc tgggtctagg ccgacgggtc ctcgccggcg aagccaccga
2436241 gttcaccatg cgggcaacca ccgttatctg gctggcgccg ctactgctgt cggtgcccgt
2436301 cttcagccgg gacacttact cgtatctggc ccaaggggcg cttctgcgcg acggtctgga
2436361 tccttacgct gttggcccgg tcggtaatcc caatgcgctg ctggacgacg taagcccgat
2436421 ctggacgatc accaccgcgc cctacggtcc tgcgttcatt ctggttgcga agttcgtcac
2436481 ggtaatcgtc ggcaacaatg tcgtcgccgg aaccatgctg ttgcgtttgt gcatgctgcc
2436541 cgggctggcg ttgctggtct gggccactcc acgcttggcc agccatctcg gcacccacgg
2436601 cccgaccgcg ctgtggatct gcgtgctgaa cccactggtc ctcatccatc tgatgggcgg
2436661 ggtgcacaac gagatgctga tggtgggtct gatgaccgcc ggtatcgcgt tgaccgtcca
2436721 gggccgtaat gtcgcgggga tcatcctgat caccgttgcg atcgcggtga aggccaccgc
2436781 cggaatcgcg ttgcccttct tggtctgggt ttggctgcgt catctgcgtg agcgacgggg
2436841 gtaccggccg gtccaggcgt tcctggcagc cgccgcgata tcgctgctga tcttcgtcgc
2436901 ggtgttcgcg gtgctgtctg cggtagccgg cgttggccta gggtggctga ccgcgctggc
2436961 cggctcggtg aaaatcatca actggctgac ggtgcccacc ggggcggcca acgtgatcca
2437021 cgcgctgggc agagggctct tcacggtcga cttctacacc ttgctgcgga tcacccggct
2437081 gatcggaatc gtgatcatcg cggtgtcgct gccgctgttg tggtggcggt tccggcgcga
2437141 cgaccgggcc gcgctgaccg gggtcgcatg gtcgatgctg atcgtggtgc tgttcgtacc
2437201 cgccgccctg ccgtggtact actcctggcc gctggcggtc gctgccccgt tggcccaggc
2437261 acgacgggcg atcgcggcca tcgccgggct ctcgacttgg gtgatggtga tcttcaaacc
2437321 cgacggatcg cacgggatgt attcgtggct gcacttctgg atcgccaccg cctgcgcact
2437381 gactgcgtgg tatgtcctgt atcggtcacc ggaccggcgc ggagtgcagg ctgcaacccc
2437441 ggtggtcaat acgccatagc ctgggcccgg cgcaccacct cgcgagcctg gtgggcatgc
2437501 aatgcatcga cgggacgggc gttgctgacg gcgtcacgcg agccgtcgcg ggtgatggtc
2437561 agcgacggat cgggggtaaa cagccagcgc ataatctcgg tgtcgcgata gcccccgtcg
2437621 tgcaggatgg tcaacagccc cggcaggctc ttgaccacct gaccggagtt ggtgaagaag
2437681 acctgaggga tcaccacgcc accagcgcgc cgcacggcca ccagatgacc ttcccgcagc
2437741 tgctgggcca ccttgctgac cggaacgccg agcagctcgg cgacccgggg caggtcgtac
2437801 gtcggttcgt cagggtccaa aacgtcatcg ccagcgggaa tgctgcccac ccgcgcaagt
2437861 gtagagcctg gtgcgcggcc aggcatgcgc gttaggcttc cgttctgcat ccaatcgcgg
2437921 cggccaccta cgatgacccc gtggtcgaag ctggcacgag ggacccgttg gagagcgcgc
2437981 tgctggacag ccgctatctg gtccaggcca agatcgccag cggcggcacc tcgacggtct
2438041 accggggcct ggatgtccga ctcgaccggc ccgtcgcgct gaaagtgatg gattctcgct
2438101 acgcgggcga tgaacagttt ctgacccgct ttcgactgga ggcccgtgcg gttgcccggc
2438161 taaataaccg cgcgctggtc gcggtctacg accagggcaa agacggcagg cacccgtttc
2438221 tggtgatgga gctcatcgag ggcggtaccc tgcgcgagct gctgatagaa cgtggtccca
2438281 tgccgccaca tgccgttgtg gcggtgctgc gcccagtgct tggcgggctg gctgccgccc
2438341 atcgagccgg tctggtgcat cgcgatgtca agcccgagaa catcttgatc tccgacgacg
2438401 gcgacgtcaa actcgccgat ttcgggttgg tccgcgcggt cgccgccgct tcaatcacgt
2438461 ctaccggcgt catcctgggt accgcggcct acctgtcccc tgagcaggtc cgtgatggaa
2438521 acgccgatcc tcgaagcgac gtctactctg tcggcgttct ggtctacgag ctgctaacgg
2438581 ggcacacacc gttcaccggc gactcggcct tgtcgattgc ctaccaacgg cttgatgctg
2438641 acgtgccgcg tgccagtgct gtaatcgacg gtgtaccgcc acaattcgat gagttggtgg
2438701 catgtgcaac tgcccgcaac cctgccgacc gatacgccga tgcgatcgcg atgggcgccg
2438761 atctggaggc gatcgccgag gagctggccc tgcctgaatt ccgggtaccg gcgccgcgca
2438821 actccgctca acaccggtcg gccgcgttgt accgcagccg gattacccag caagggcagc
2438881 tgggtgccaa accggttcac caccctactc gccagctgac tcgccaaccc ggcgactgct
2438941 ccgagccggc ttcagggtcg gagcccgaac acgagccgat caccggccaa ttcgccggca
2439001 tcgcaatcga ggaattcatc tgggcgcgac agcacgcccg tcgaatggtg cttgtctggg
2439061 tgtcggtggt gctggcgatc accgggctag tggcgtccgc ggcatggacg atcgggagca
2439121 acctgagcgg cctgctctaa ggcaggcgag cagtcgcaaa agcccccatt tcggcacgaa
2439181 aatgggggct ggtacgtgaa ttaaggtgac cacggcaagc gtgacccgcc ggcgactgca
2439241 gcgaagccgg gtctgttggt gacagtgtgt atgtcggggt ttcaggcggc aggttcgagg
2439301 gtgaccccca atccttgggc ttcgagtttg gcgacgaggc gacgtcgttc tttgtcggga
2439361 tccatgcggg tggtgaagta gtcggcgccg agatcctggt aaggccggcc ggtggccagc
2439421 acgtgccaaa tgatgacgat cagcttgtgg gcgacggcga tgatcgcctt cttgttggca
2439481 gcgggactgc ggaagccacc gaacttgcgg acctggcggc ggtagtactc gcgcaggtag
2439541 ccatcggtgc gcacggcggc ccacgcgcac tcgaccagga ccggctgcag gtgctggttg
2439601 cctgtgcggc gggcaccgtg atggcgtttg ccggccgatt cgtggttgcc cgggcacagc
2439661 cgcacccacg aggccagatg ctcagccgag gggaaccagg ccgccgggtc ggcgccgatt
2439721 tcagagatga ccgtcgccga ggcacccacc ccgatccccg ggatcgatgc aatcagctcg
2439781 cgtcgggcac aaaagggatg catcagctgc tcgatctgct cgtcgagagc accgatcatc
2439841 gcatcgagct gatccagatg agccaggtgc aacctacaca tcagggcatg gtgatcatcg
2439901 aagcgccctt ccagcgcccg ctgcagatcg gggatcttcg agcgcataag gtgcgcttga
2439961 tcgtcttgcg cccgtcagga ccctcgcccg gcacccacac cgccaccgcg atgatgtcct
2440021 ggcccacatc aacaaaggcg caccgctcgt acagaatatg catcccacca gcccctttcc
2440081 ggctcagcgt cgcaaccaac aacgcgcgct gcgaagggag cccccaaaca tgaactaaag
2440141 agactggtac tcgcgctcgt agcagcaacc gggacacacc cgaaagtggg ggggctccaa
2440201 cgtcagtctc ttgcacggcc acacacagcc aagcccctac gacgtcgaca ccgcaacgca
2440261 cgcaccgatt ctcattcacc atgagcgggc gcaccagcgc ccatcatgtt cttttacgac
2440321 tgctcgccga gctagtcccg cagcatctcc gcgaccagga acgccaactc cagcgactgc
2440381 tgggtgttca gccgcggatc acatgccgtc tcatagcggc cggccaagtc cgtctccgaa
2440441 atgtcttgcg cgccaccaag acattcggtg acgttctcgc cggtaatctc gacatggatg
2440501 ccgcccggat gggttccgag ggcacgatgc acctcgaaaa aaccctgcac ttcatcgaca
2440561 atgcgatcga agtgacgggt cttgaacccc gtggacgact cgtgggtgtt gccgtgcatc
2440621 gggtcgcatt gccagatcac ctgatgcccg gtggcctgga ccttctccac gatcggtggc
2440681 aacagatcgc ggaccttgtg gttgcccatc ctgctcacca acgtcagccg gcccggctta
2440741 ttgtgcgggt cgagccgctc gacgtactcc acggccagtt ccggggtcat gttggggccc
2440801 aacttgaccc cgaccggatt agcaatcacc tgggcaaacg cgatgtgcgc gccatcgatt
2440861 tgtcgggtcc gctcgccgat ccacacggtg tgtgcggaca ggtcaaacag ttgtggttca
2440921 ccgtcgtcac cgtcggacaa cctcaacatg gcgcgctcgt agtcgagcac caaagcttca
2440981 tggctggcat agatttcggc ggtctgtaga ttgcggtcgg ccaccccaca ggcactcatg
2441041 aaccgcagcc cacgatcgat ctcggtggcc agcgcctcat agcgcgcgcc ggccggcgag
2441101 gtccggacga attcccggtt ccagtcgtga accagatgca gcgacgccag gcccgacgaa
2441161 gtcagcgcac gcaccaagtt catcgccgca ctggcgttag cgtaagcccg gaccagccgc
2441221 gacgggtcgt gctcgcgcgc cgcggcgtcc ggggcgaagc cgttgatcat gtcgccgcgg
2441281 taagaccgca gacccagcgc gtcaatgtcg gctgaccgag gcttcgcgta ctgaccggcg
2441341 atgcgggcca ccttcaccac tggcatgctg gcgccgtagg tcagcaccac ggccatctgc
2441401 aacaaggcac ggacattgcc ccgaatatgg ggttcggtgt tgtccatgaa tgtctcagcg
2441461 cagtcgccgc cctgcagcag gaaagcctca ccctttgcca cctgggccag ctgctcttgc
2441521 agccggacga tctcggacgg caccgtcacg ggtggcacgc tctccaacac cgtgcgcatc
2441581 gccaacgcct ggtcggccgg ccaggtgggt tgctgggccg ccggcttggc cagcgcggcg
2441641 tccagtcgtg ttcgcaggtc agtcggcagc ggcggaagcg acgggagctg gtcgatcggt
2441701 atgtcgacgg tccagttcat cggtccatgg taaccgggga tttcctgacg gctgctcagg
2441761 gcgaggttcg ctcggaggtc ctcgccggcg ggatctgact gtccgtctcc tcagcgggcc
2441821 gcgccgcggc ccgcatcgtc tgtggacgtg atgagacgaa accggcgcag ctgatctcgg
2441881 gcatcgacca gcgcgtcgtg gacgtcgcgt ggccgcggcg gcatccgggg gcatccccgg
2441941 tcctcccaca actgccgcag ttcccgggtg aaacggggca ctgtgggtgg caaggcagtc
2442001 atcgggcccc acaattgaca cagcgctaca tggtcgtagg cccccaccca ggcccacaac
2442061 tcgatcgaat ccgtgccgtc gatgcggagg aattcttcca ggtcaagacg aatctgctgg
2442121 cgcgagcgcc acagttgcga ggcgggcggc ggcagcttgg gcagcacatg ggtgcgcacc
2442181 cagctgccgg cccgctcggg atcgaattcc gtggatactg cgtagtattc gcggccgtct
2442241 tctgcgacca ccccgatcga gatcaactcg atggtgtgcc catcctcgat gaattcggtg
2442301 tcgtagaagt accgcaccgc cgcagcctaa tccgaccaga ccgagccgct gatcagaatg
2442361 ggcgcggttc tctccggcgg tggtgcgggg cgcacgtcct ggtcgagctg ggcgtcgacc
2442421 gcgcgctcgt cgggcatccg tggcgtcccg gcgatcacgt attgcagcca cagcttgatc
2442481 cgcaccaccg ggcggcgcca tgtccgttcc cgctgtagcg cacggcgcat cttttccggg
2442541 tggcgggtgt agcgccaccg ggcccacgga gcgtgcggac gcgacagccg gactgcgccg
2442601 acgaccaaca gcacgacaac gaacatgcca agcaacccgg tccaaacctt gcccttgagc
2442661 agcaccacca ccgccaacgg caacgtcaag accaatcctg cgatcagggt ggtttgcagc
2442721 accacccagt tggcgccttg ccgaaccggc aggaagaaga tcagcgggtg taggcccatg
2442781 atcaacagcc ccgcgacggc cactgcggca aagacggcgt ctaccgacgt gcgtccgtct
2442841 tcctcccagt agacatcgga cagatgcagg atcagtgcgt actcgtcgag caccaaggcg
2442901 gccccgactc cgaaaatgct cgccgctatg gtgaattcgg gttctcgacc gtcgactgac
2442961 aaggtgacca gcgtcagccc ggagatcatc accagcacca ccccaaacgc gacgtggtgg
2443021 atgtgcaccg acccgatgtg gacatttcgc ggctgccacc acctggccgg ccgaccgtcc
2443081 gcggcgcgac ggtggataaa ccgtacaaaa ctacgcgtga cgaggaaggt caggacaaag
2443141 gcgaccaagc agcacaacaa cggcagccgg ccacggtcga cgatgtcgtg ctgcagccag
2443201 tggaacacct ccaaaaagct acgcccacct tgactgcata tgcaggcgcc gtacagcgcc
2443261 accatgcgcg cctacgcgaa actactaggc tgttctgcga catgagtgca tggcgggcgc
2443321 ccgaggtggg cagtcgactc gggcggaggg tgttgtggtg cctgctgtgg ctgctggccg
2443381 gcgtggcgtt gggctacgtg gcctggcggt tgttcggcca cacgccgtat cgcatcgata
2443441 tcgacatcta tcagatgggc gctcgagctt ggctggacgg gcgtccgctg tatggcggtg
2443501 gtgtgttgtt ccacacaccc atcgggctga acctcccgtt cacctatcct ccactggcgg
2443561 ccgtcctgtt cagcccattc gcctggttgc agatgccggc tgccagcgtc gcgatcacgg
2443621 tgctaaccct ggtgctgctg atcgcgtcga cggcgatcgt gctgaccggc ctcgacgcat
2443681 ggccaacctc ccgactggta cccgcgccgg ctcggttacg ccggttgtgg ttggccgtgc
2443741 tcatcgtggc tccggcaacg atttggctgg agccgatcag ctcgaacttc gctttcggtc
2443801 agatcaatgt ggtgctgatg accctggtga tcgtcgactg cttcccacgc cgaacgccat
2443861 ggccacgcgg gctgatgttg gggctgggga tagccctcaa actcaccccc gcggtgtttc
2443921 tcctctactt cctgctacgt cgggacggtc gggccgcgct gacggcgctg gcgtcgttcg
2443981 cggtcgccac gctgctcggt ttcgtcctgg cgtggcgcga ctcctgggag tactggacgc
2444041 atacccttca ccacacggac cggatcggcg ctgccgcctt gaacacagac cagaacatcg
2444101 cgggcgcact cgcgcggttg acgattggcg atgacgaacg cttcgcactg tgggtggccg
2444161 gatccctgct cgtgttggca gcgaccatat gggcgatgcg gcgagtgttg cgggccggcg
2444221 agccgaccct ggctgtgatc tgcgtcgccc tgttcgggtt ggtagtttcg ccggtctcgt
2444281 ggtcacacca ttgggtgtgg atgctgccgg ccgtgctggt gattgggcta ctgggttggc
2444341 gtcgccgcaa cgtcgcgttg gccatgctca gcctggccgg ggtggtgctg atgaggtgga
2444401 caccgatcga cctgcttccc caacaccggg agacgactgc ggtctggtgg cgtcaactcg
2444461 cggggatgtc ctacgtgtgg tgggcgctgg cggtcatcgt cgttgccgga ctcaccgtta
2444521 ccgccaggat gacgccgcag cgctcgctta cgcgcggact gaccccggcg ccgacggcca
2444581 gctgactagc cagcggctgt ctcggggatt cgtgcggcgt ccgttgaatt gggatttgca
2444641 ccggcaccgc ccgcgttgcg gccgtctttg acactggcgg catagatgtc gacgtactcc
2444701 tgacccgaga gccccatcag ctcatagatc acttcgtcgg taacggcccg ctcgatgaaa
2444761 tggttaccgg ccaacccctc gaaccgggag aagtccatcg gcttgccaaa ccgaacggtg
2444821 accctgccga acctcagcat cttcctgccc ggcgggttga cgacgttggt accgatcatc
2444881 gccaccggaa tcaccggaac cccggtgtgc aatgccaacc gggctaggcc ggtcttgcct
2444941 ttgtagagcc gaccgtccgg cgagcgagtg ccttctggat acatgcccag cagcttgccc
2445001 tgacccagca acaccactgc cgtctgcagt gcgccctgcg cggagtcggc attggtgcgg
2445061 tcgatgggaa cctggccgga gacgctgtag aaccagcggt tgatccagcc tttcagtccg
2445121 gtgccggtga agtattccga tttcgccagg aaccagatac gacggcgaac taccaacgga
2445181 aggtagaagc tatccgccac cgcaagatgg ttactggcga ggatggccgg acccgaactc
2445241 gggatgtatt ccagtccttc aactttcggg cgaccaagca acgtaaagag cggacccatg
2445301 aaaatgtact tgaacaggta gtaccacatg gccctccctc tcgcccacac cggatggtgt
2445361 ctgcgccaac tgtacccatc cgcgatggct gcgactacct gcgcgggcag cggctcactc
2445421 ctcgatggta accgggatgg cctggtagtg ggatttcatg ctgccctcgc cgttggtatt
2445481 ctcgccgcct gacgcaccgg tctggccgcc gcccggcggg ccttcgggtg gcggtttcgc
2445541 cgaccggtca atgtcgtcga ctatggcgcg gatcacctcc agcagagcca gactgtgatc
2445601 cgcgatgacc gtcagcagcg gatgctgctc gccggttacc aacgctgcca acgcgcacaa
2445661 cggacaccac acttgctggc acttgccggt cccgggacct ccacccgaag ccatcgccgc
2445721 cgccacccgc accgcggggt cgatcccatc gaggattgcc tgcgccagct tgcgcagctc
2445781 gggacgaacg tcggtatggg ccccgctcac gtcggccaca cctccggatt tggtcggaaa
2445841 cgaactgtta actcaccacc ccgcagatgc gcgtccagca ccgtgcacct ccgcaatacg
2445901 gacgccaacc gaactcggcg ccgcatcccc ccagcactga cgatcaagtc gtcgtcggcc
2445961 cggcccaacg tcagcgtccc gggatcgagc tggggcaacg ctagccgcag tcggtatatc
2446021 gacgccaatc ccgacccgga ttccaggtcc acaataggct gtagcgggcc tggcggcgcg
2446081 cttccttggc gacgacgggc actatcgagc aacccgccca gggccttggg gccgatcggt
2446141 tcgccggcca agtgcggcac cagcaccagt gccacgtcac cgatggtggc atcgaggtcg
2446201 tcgaggacgg cacgctgctc accgatgcgt tcggcatacc agtggaaagc cggatggtcg
2446261 ggcagactgc gatactcata gttctcgtct tgcaccagaa gctgattgac gagcagctct
2446321 tcgacccgga cccccatgag cgccaacgac cccagcgtcc ggaccgcctc agcggcgacc
2446381 acccgctccg gagtcagcac caggtgggca ctgaccaggg caccgtcggt cagcaatgtg
2446441 cttagccgct cgacgctggc gcggatgcgc tccagcagtt ccgccagcac ggctgacctg
2446501 ccgtcgtcgg cgccgatgga caacctgcga tgccgcggcc aggcacgttc gacgtacagc
2446561 ccgaaggtgg cgggtagcgt caacatccgc aaggcgtccg ccgtcgaggc gcagtcgacc
2446621 acaatccgat cccatcgtcg ggctgccgca agctcgccga cggcgtgcag ccccagcacc
2446681 tcctggatcc cgggcagcgc gcagagttct tcgggcgcaa tgctgctcaa ctcggagccc
2446741 ggaaatctgc ggtccagggt ctcgaccacg tgcaaccacc ggccctcgag cagggccagg
2446801 gtatccagcg ccagcgcgtc gagaaatccg cccccggctt cggggtcgta ggcgagcacg
2446861 cgaacaggat cgccctgacc ggtaggcggg accgcgatgc ccagcacgtc gcccagcgag
2446921 tgcgcctggt cggtggatac caccaacact cgctggccgg ccccggcatc acataccgcg
2446981 gtggcggacg ccagagtgga ctttcctacc ccgcccttgc cgacaaagag actgatccgg
2447041 gcctgagccg gcgtaccgga atcactcagc cctcgactcg tttcttcaga tccttcaacg
2447101 cgccgtctat caacctgcgt tccgccttac gcttgagcat cccgatcatg gggacagcaa
2447161 ggtcgacggc aagctcgtag gtgacctcag tgccagaacc cttgggcgcc aagcgatacg
2447221 tgccttcgag ggactttagc agcgagctgg attcgagagt ccagctaagc gattggcggt
2447281 cttccggcca ctcgtaggac atgatcaagg tgtctttgaa gatggctgcg tccatcaaca
2447341 ttcgcgctcg tttcgggtag ccctcgtcgt cggcctctag gatctcgact tccttatact
2447401 ccgaaatcca ttgcgggtag gcttcgatgt cggcgatcgc cttcatcacc tcgcctggat
2447461 ccgcgtcgat gtaaatcgtc tgtgtcgtct tgtccgccac ctggctactt ccctttcccc
2447521 gcaagcgggt cggccccgat catctgcggg agctcccgat ctcccgggga gaaacggtac
2447581 tccctcgtgc caaccttgac ccggttaagt taccggagaa accccgatgg ggcgtgaccg
2447641 ttctagcact gtcttgacct cgaaggccat ttttttgccc gcgacccgtc ggtggtgcgt
2447701 cattctggcc aggttcatcc gggccagctg ccaggctgct accccggtcg gttcggcgtg
2447761 caggaaatag tgcagtagca ccccatccat cgacggttcc agccagatct ccatggtgcc
2447821 ggtcagggcg ccggtaaccg tccacctgat tcccttgtcg gcacgatcct cggtgacctg
2447881 tagccgtagg tcaggccacc accgacgcca gctgcatcga tccgcgaccg cggctgaaac
2447941 ccgcgcggcg tcggctgcga cataggtctc gtcagcgatc tggatgctgt tcatcgcctc
2448001 agcttcacat acccgaggcc gtgggcaagc cggaccccga agggcaccaa ccaacggaca
2448061 cgcgatatcg gtctattccg caccggcatc aacccctcta ggcttgacga cagcaaaccg
2448121 gacccggaag acggcaacag gtcaagtgag gtgttgatcg tgcgtgagat tagcgtcccc
2448181 gccccattca ctgtcggcga gcacgacaac gtcgcggcca tggtgttcga gcatgaacgt
2448241 gacgatcccg actacgtcat ctatcaacgc ctgatcgacg gcgtctggac cgatgtcacg
2448301 tgtgcggagg cagccaacca gattcgtgcc gcggctctcg gtttgatttc actgggggtg
2448361 caggccggcg atcgggtagt catcttctct gccacccgct acgagtgggc gatcctcgat
2448421 ttcgcgattc tggctgtggg tgcggtcacc gtaccgacct acgagacctc gtcagcggag
2448481 caggtgcgct gggttttaca agactccgaa gcggtggtgt tgttcgccga aaccgactca
2448541 cacgcgacaa tggtcgccga actctccggc agcgtgcccg ccctgcggga ggtactgcag
2448601 atcgccggtt cgggtcccaa cgcgctcgat cggctcacgg aggcgggcgc ctcggtcgac
2448661 ccggccgagc taaccgcccg cctcgccgca ctacggtcga cggacccggc gacgcttatc
2448721 tacacctcgg gcaccaccgg acgacccaag ggctgccagt tgacccaatc caacctggtt
2448781 cacgagatta agggcgccag ggcatatcac ccgacgctgc tgcgcaaggg tgagcggctg
2448841 ctggttttcc tgccgctagc tcatgtgctg gcgcgcgcga tcagtatggc cgccttccac
2448901 tccaaagtca ccgtgggatt caccagcgac atcaagaatc tgctgccgat gttggcggtg
2448961 ttcaagccga cggtggtggt gtcggtgccg agggtgttcg agaaggtgta caacaccgcc
2449021 gagcagaacg ccgccaacgc cggcaaaggg cgaatcttcg cgatcgccgc gcagaccgcg
2449081 gtcgactgga gcgaagcttg cgaccgcggc ggaccggggc tgctactgcg cgccaagcac
2449141 gcggtgttcg accggctggt ctaccgcaag ctgcgtgcgg cactgggtgg caactgccgc
2449201 gccgccgtct ccggcggcgc gccgctgggt gcgcggcttg gtcacttcta tcgcggcgcc
2449261 ggtctcacca tctacgaggg atacggcctg agcgggacca gtgggggcgt cgccatcagc
2449321 cagttcaatg atctaaagat cggaactgtc ggaaagccgg tgcccggcaa cagtctacgc
2449381 atcgccgacg atggcgagct gctggtgcgc ggtggcgtgg tattcagcgg ctactggcgc
2449441 aacgagcagg ctaccaccga ggcattcacc gacggctggt tcaagaccgg tgatctcggt
2449501 gcggtggacg aagacgggtt cttgacgatc accggccgca agaaagaaat tatcgtcacc
2449561 gcgggcggta aaaatgtcgc ccccgctgtg ctggaagacc agctgcgggc ccacccactg
2449621 atcagccagg cggtggtggt tggggacgcc aagcccttca tcggcgcgtt aatcaccatc
2449681 gaccctgagg cattcgaggg ctggaagcaa cgcaacagca agacagctgg cgcgtcggtg
2449741 ggcgatttgg ccaccgaccc cgatctgatt gccgagatcg acgcggccgt caaacaggcc
2449801 aatcttgcgg tgtcacatgc cgagtcgatc cgcaagttcc gaatactgcc cgtcgacttc
2449861 accgaggaca ccggcgagct gaccccgaca atgaaggtca aacgcaaggt ggtggccgag
2449921 aagttcgctt ccgatatcga ggcgatctac aacaaggaat agccgactgt gcccggctcc
2449981 tccccggccc gctcaacggg ccgcatcgtc gccgcgcaga aaatctgcta gcttggcggc
2450041 cagcgtgtcc caacgccact gcgccgtgac ccattctcgg ccggcggcgc ccatcgcgac
2450101 ggcccgatcc cgatcgatca gcaactcggc cacggcgtcg gccacccggt ccaccgacct
2450161 accgtcgacc actagcccag tcttgttgtg ctgcaccgtt tccggcgctc cgccagaatt
2450221 gccggcgatt accggcacgc cggcggcgga ggcttcgagg aacacgatgc ccaagccctc
2450281 gacgtccatc ccggcgccgc gggtgcggca tggcatggcg aacacgtcgg ccagtgcgtg
2450341 gtgggcggga agttcgtcgg ttgccacgcc gccggtgaac gtcacgtggt cggccacccc
2450401 acagtcgtga gccagcttgc gcaacgtctc tagatatgga ccgccgccga caatcaccaa
2450461 cgcggctcca tcaacgcgac gccggatcga cgggagcgcc gtgaccaggg tgtcctggcc
2450521 tttgcgcggc accaaccgcg acagacacac taccgtgggc cgctcgccta gccgatagcg
2450581 cttccgcaac tcggcgcgtg cggccggatc ggggcggaac cggtcggtgt ccactcccgg
2450641 cggtaggtat tccaacgaag ccgcgggccc gaacgcagaa gcaaaccggg accgcgtgta
2450701 gctgctgacg aaagtcacca cgtcggtgcc gtcgccgatg cggcgtagca ccgatcgagc
2450761 gaccggaagc atcgaccagc ccacttcgtg gccgtgcgtg ctggccaaca cccggctagc
2450821 tccagccagc cgggcacgcg gggccagcag ggccagcggt gcggccgcac cgaaccagac
2450881 ggtttcgatg tcgtgctcgg cgatcagccg gcgcatccgg acatcgaccg ttggacccgg
2450941 cagcatcacc gtgctgggat ggcgcaccac ccggtaaccg gcagcacggg ctgcgtcgtc
2451001 gaaggcgtcg gcgcctttcc actgcggtgc atacactgtc atcgcatgcg ctcgggagcc
2451061 gaccagccga ccgacgaact cccccagata ggactggatg cccccgcgtc ggggtggaaa
2451121 gtcgttagtt accaacagga cccggctcac ctgggtcagg ctagcgggtc caccttgcgt
2451181 gagcagacgc aaagtcgccc aaaatcgccg gtttccgggt gattttgcgt ctgctcgcgg
2451241 cggaagctag cccattagcc accgctgcca gcgcgcgagc aggccagcgg cgtcaatgcc
2451301 gaggacgtcg tgggcggcgg tagccaggtc gaagtgtccg acaccacaag tggccagata
2451361 aagctcacgc agcttggcgg taccgtaggc ggccgcgacg aaccgagcga accaccacgc
2451421 gcggtcatat gccagcgagc gctgtggccc cggagtgtcc aggtcggtgt ccgacggtaa
2451481 cgacagcgcc acagacaccg catccgcggg cggcggggtc ttgggcctgg caacgaaatc
2451541 ggccaccccc tcggccagcc atcgaggtgc atccagggcc gtgtcggccc gggccgcata
2451601 gtgaaaaagc tcgtggccca acactattcg tagcgccgct gggctcatgt gtgccgcgcc
2451661 cggcgcgaac acaatccgtt ggccgaccac cgtgcgacga gcaggatcga cacggtcgac
2451721 caccgtgatc gcggcgatgt ccgcccattg cgacgccaaa cccccgcctg cggcggcatg
2451781 aaactgctcg tcgctaccgg cggcaaccac aaagatgtcg tgcgaccaat cggtgcccca
2451841 gaatgccacc acctcgtcga ccgcggcgtc gatgcccgcc gcgatgcgcg acagcaagcg
2451901 gtcggtggcc gcgccaccaa ggctgagcag ccgcaccgtg cggtcgtcgg cgacccgcag
2451961 cgcgacaaac ccatcggctg gcgcgaccac ctgtgccggt gctgcaggtc catcgcgcac
2452021 cggattacca gacagggccg ccgcgccaat cagctccgca acaaacagac aggccagcaa
2452081 gatccgaggg caaagccgcc gcgcgacgag ccggtcagta acggcgggcg tcgtagatcg
2452141 gccccgacga gtccatcggc accacccgca ccggaacacc gtaggtggag gaatgaacca
2452201 taagaccatc accgatgtag atgcctgcgt gtgacgcgtc ggaatagaag gtcaacacgt
2452261 cgccgggctg cagatccgac aacgcgaccg gctgaccacc gtgagccagc gcctggctgg
2452321 agtgcggtaa cgcgatacca gcctgctgga acgcccacat caccaagcct gagcagtcga
2452381 acccgccggg cgcggcacca ccccacgcgt agggcgcgcc gacctgcgtc aacgccgctt
2452441 ggacaacggc cgtacggtcg ccgccagcgc cgtcgggctg cacgaaaggc aatccgggca
2452501 tcccaccagg cggcggcgcc acgccaggcg ccgggccgtc gccaggcggc gcaccgggcg
2452561 gcaacgccgc aggtggggcc ccgggggcga tcgcagcaac cgccgggacc ggtcctggat
2452621 cagcgagggc cgtgcgctcc tccggcgtca acgcgacgta ttgcgacttg acgacggcaa
2452681 tctgcacctg cagctggctc tgtttgtgct gcagattcgc tcgtaccgcg gcagcttgct
2452741 cggccgcgga cctggcatcg gccgccgatt tggctgcagc ctgctcggcc ttgacggcct
2452801 gttctccagc ggccttgaaa cgggccatct gcgtggacat ttgatgcgcc atcacccgct
2452861 gtaccgatag ccgatcgatc aacagttgcg gggactccgc cgtcaggatc gcatccatgc
2452921 cgtgggtacg accacccatg taggtagcgg ccgcgacctt gttcaccgcc gtctgaaaag
2452981 tcgccaagcg tgctctcgca gcatccaagg ccgttctgtt gtccgcaagc ttctggtcgg
2453041 cggcccgctg ggcagcgagc ttttcgttga gatccagctg cgcactgtgc agcgcctcgg
2453101 tggtctgctc ggcctgccgg gataactcgt tgagcttggc cagcgcgtcg tcggccggat
2453161 cagccagcac attcgcggcc aggacgccgg aggagacggt gaagctcgca aagaaaccta
2453221 tggcggaccg catgattaca cgcgcgatca accacctctg gtcgagcctc aaaatttgct
2453281 tccttaaacg ggccatcgac ggatgacgtc gagctggttt aggtctcaaa caggttacga
2453341 aacgatctcg gaattgtcca aaaggggaag ttaagaaaat ggatagattt ctaccatttc
2453401 gctgtggacg atcgtacttc tgctataggg ctccaggggc atcgacacgc aacgacctta
2453461 cgcgacaccg gatccgcgct ggcggcggac cggcaccagg cgcaaccgag gggccaatcc
2453521 gacatcggcg agcacttcca acgcagcacg ctcgtcatgc gacaggcttt ccggtacccc
2453581 gatgagcacg ctgaccacac agtcgcggca tccagatccg cgcgccgcgc aatcgtcaca
2453641 gtcgattacc accggcgccc ccggcccggg ggctgtgccg ccgctagtgt ctggtccgct
2453701 gcgtgccatg gggtcgttcc tctcggcttg gctcatgagg tcgtccgaac gctaatcgcg
2453761 agcaccgaca tccgttgccg ccgcgtgcgc gctcggcgta gggagcgttt gcgtgtcagt
2453821 gcaggggcct aacgtcgcgg ccatgggtgc aaccggtggg actcagctga gtttcgccga
2453881 cctggcacac gcccaggggg cagcctggac cccagccgac gagatgtccc tgcgcgagac
2453941 caccttcgtc gtggtcgacc tggaaaccac aggtgggcgc acgacgggta acgacgcaac
2454001 accgccggac gcgatcaccg aaatcggggc ggtcaaggta tgcggcggcg cggtgctcgg
2454061 tgaattcgcc accctggtaa acccgcaaca cagcattccg ccccagatcg tgcggctcac
2454121 cggtatcact acggcgatgg tgggtaatgc cccgacgatc gacgccgtcc tgccgatgtt
2454181 cttcgagttc gccggcgact cggtgctcgt ggcccacaac gctgggttcg atatcggatt
2454241 cctgcgcgcc gccgcgaggc ggtgcgatat cacctggccc caaccacagg tgttgtgcac
2454301 gatgcggctg gcccggcggg tgctgagccg agacgaagcc cctagcgtgc gtctggccgc
2454361 gctagcgcgg ctgttcgccg tcgccagcaa ccccacccac cgcgccctcg acgacgctcg
2454421 cgccaccgtc gacgtgctgc acgcactcat cgagcgagtg ggcaaccagg gcgtgcacac
2454481 ctatgccgag ctgcgctcgt atctgcccaa cgtgacccag gcgcagcgct gcaaacgggt
2454541 actggcggaa acactgccgc accggccggg ggtgtacctg ttccgcggac cgtcgggcga
2454601 ggtgctctat gtcggcaccg cggcggactt gcgccgccgg gtaagccagt acttcaacgg
2454661 caccgaccgc cgcaagcgga tgacggagat ggtcatgctg gccagctcga tcgatcatgt
2454721 cgaatgcgcg caccccctgg aggccggtgt ccgtgagctg cggatgctgt cgacgcatgc
2454781 cccgccgtat aaccgcaggt cgaagttccc ataccggtgg tggtgggtgg cgctcaccga
2454841 tgaagcattt ccacgcctgt cggtcatccg ggccccgcga cacgaccgcg tcgtcggccc
2454901 gttccgatcc cgctccaagg ccgccgagac ggcagcgctg ctggcacgct gcacgggact
2454961 gcgaacctgc accactcggc tgacacgttc cgcccggcac ggacccgcct gccccgagct
2455021 ggaagtgtcg gcctgcccgg ccgcccgcga cgtcacggcc gcgcaatacg ccgaggcggt
2455081 actgcgcgcg gcggccttga tcggcggatt ggacaacgcc gcgctggccg cggccgttca
2455141 acaggtcact gagctcgccg agcgccgtcg ctatgagagc gctgcccgac tgcgtgacca
2455201 cctcgccacc gccatcgagg cgttgtggca tggccaacga ttgcgagcac tggccgcgct
2455261 gcccgagttg atcgccgcca agccggacgg ccccagggag ggcggctacc aactggccgt
2455321 cattcgccac ggccaactcg ccgctgccgg cagggcaccg cgcggggttc ctccgatgcc
2455381 tgtggtcgac gccatccgcc gcggcgctca ggcgatcctg cctacgccgg caccgctcgg
2455441 cggggcactg gtggaggaga tcgcgctcat cgcccgctgg ctggccgagc cgggagtgcg
2455501 catcgtcggg gtctcgaacg acgccgcagg gttggcctcc ccagtgcgct cggccggccc
2455561 gtgggcagcg tgggcggcaa cggcgcgctc ggcccagttg gccggcgagc agctcagcag
2455621 aggttggcag tcagatctgc cgaccgaacc gcacccatcg cgcgagcaac tgttcggccg
2455681 caccggtgtc gattgccgca ctggcccgcc gcaacccctc ctcccaggcc ggcagccatt
2455741 cagcacggct ggataatccg gcgtgggcga cgatcgcacc ggcggcgttg agcaccacag
2455801 cgtcccggac cgggcccctg gcaccgccca acaccgcgcg caccgcggcc gcgttggctt
2455861 gcgcatcgcc tccagccagc tggtcaagct gggcgcgcgc aaacccgaat ccggcgggat
2455921 caaacgtcaa cttatccacg ctgcccgccg caacgcgcca gatcgtgctc gtggtggtgg
2455981 tggtcaactc gtccagccca tcgtcgccgt gtaccaccag cacactggac cggcgcgcag
2456041 caaacacccc ggccatcact tcggcgaggt cggcgaacgc gcatccgatc agtccagccc
2456101 ggggccgggc cggattggtc agcggcccga gaagattgaa cacggtgggc acaccgatct
2456161 cgcggcgtac cgcggccgcg tgccggtagg agggatggaa ccgcggcgcg aagcagaacc
2456221 cgatcccaac ctccgcgagg ctgcgcgcga ccaggtcggg tcccaggtcg atgcgcaccc
2456281 ccagcgcctc cagcgtgtcg gcgccaccgg acaacgagga cgccgctcgg ttgccgtgct
2456341 tgaccaccgg cacacccgca gccgccacca caatcgccgc catggtggat aggttcaccg
2456401 tgttgactcc gtcgccaccg gtgccgacga cgtcgacggc gtcgtcgggg accgtatcgg
2456461 cgggcaacgg atgcgcgtgg ctgagcatga cgccagcgag ctcaccgact tcgtcggcgg
2456521 tcggagcctt catcgtcatc gccaccgcga aggcggcgat ctgcgccggc cgcgcattgc
2456581 cggtcatgat ctggtccatg gcccaggcag cctggccccg cgccagatcg cggttgtcgg
2456641 tcaaccgccc caaaatctgc ggccaggacg gcaccgatgc ggcttctgct ttcggcgagc
2456701 ccccgcgaga tccccccgaa gaaccctcag ctgacagcgc cacgcgctga tggtcccatg
2456761 aggatcaacc aaccccaacc gcgccctgaa cacgtcgacg acttgcgcta accaaacggc
2456821 cgggcgacac gcggaactga cttaccgaaa tttccgaccc gggtagagtt cgacaactac
2456881 aaagcgtcat acttgcggat gtgacgagtg ctgttgggac ctcgggtact gccatcacat
2456941 cgcgcgtgca ttcgctgaat cggcccaaca tggtcagtgt cggcaccata gtgtggctat
2457001 ccagtgaatt aatgttcttt gctgggctgt tcgcgttcta tttctcggca cgagctcagg
2457061 ccggcgggaa ttggccgccg ccaccgacag aactgaatct gtaccaggcc gtcccggtca
2457121 cgctggtcct gattgcctcg tcgttcacct gccagatggg cgtgttcgcg gccgaacgcg
2457181 gcgacatctt cgggctgcgc cgctggtatg tgatcacatt cctgatgggc ctgttcttcg
2457241 ttctgggcca ggcctacgag tatcgcaacc tgatgtcgca cgggacgagc atccccagca
2457301 gcgcatacgg cagcgtgttc tatctggcca ccggattcca tggactgcac gtcaccggcg
2457361 gcctcatcgc cttcatcttc ctgctggtac gcactgggat gagcaaattt actccggcgc
2457421 aggccacagc cagcatcgtc gtctcttact actggcattt cgtcgacatc gtgtggatcg
2457481 cgctattcac cgtgatctat ttcatccgat gagccggcgt ccgacgaaca tcccacgaac
2457541 aggagtgctc ggttgacgaa actggggttc acccgatccg gtggcagtaa gagtggtcgc
2457601 acgcgacggc gcctgcgccg ccgattgtcc ggcggagtgt tgctgctgat agcgctgacc
2457661 atcgccggtg gattggcagc tgtgctgacc cctaccccac aggtggccgt cgccgacgaa
2457721 tcctcctcgg cgttgctgcg caccggcaaa caacttttcg acacctcgtg tgtgtcctgc
2457781 catggcgcca acctgcaggg cgtgcccgac cacgggccga gtctgatcgg ggtcggcgag
2457841 gccgccgtct acttccaggt gtcgaccggc cggatgccgg ccatgcgcgg cgaggcacag
2457901 gcgccgcgca aagatccgat cttcgacgaa gcacagatcg acgcgatcgg cgcctacgtg
2457961 caagccaatg gcggtgggcc gacggtggta cgtaaccccg atggcagcat tgcaacgcag
2458021 tcgctacgtg gcaacgacct gggccgcggc ggcgacttgt tccggctcaa ctgcgcctcg
2458081 tgtcacaact tcaccggcaa gggcggagca ttgtcgtccg gcaaatacgc acccgacctt
2458141 gcgcccgcca atgaacagca aatcctcacc gcgatgctga cgggtccaca gaacatgccg
2458201 aagttctcca accgccagct ctccttcgaa gcgaaaaagg acatcattgc ctacgtgaag
2458261 gtcgccaccg aggcgcggca gcccggtggt tacctactcg gcggattcgg acccgcaccc
2458321 gaaggcatgg ccatgtggat catcggaatg gtcgccgcga tcgggctggc actgtggatt
2458381 ggggcgcgat catgagccgc gccgacgacg atgcagtggg ggtaccaccc acttgcgggg
2458441 gacgaagcga tgaggaggag cggcgcatag tgcccggacc taacccgcaa gacggggcca
2458501 aagacggggc taaggcaacc gccgtccccc gtgaaccgga cgaagccgcg ctggccgcga
2458561 tgtccaacca ggagctgctc gcattgggcg gcaagctgga tggtgtccgg atcgcctaca
2458621 aagagccccg ctggccggtc gagggcacca aagccgagaa gcgcgccgag cgttcagtgg
2458681 cggtgtggct tttgctaggt ggcgtgttcg gactggcgct gttgctgatc ttcctgttct
2458741 ggccgtggga gttcaaggcg gcggatggcg aaagcgactt catctactcg ctgactaccc
2458801 cgctctacgg cctgactttc ggattgtcca tcctgtcgat cgccatcggc gccgtgttgt
2458861 atcagaaaag gtttattccc gaagagattt caatccagga acgtcacgat ggcgcttcgc
2458921 gggagatcga ccgcaagacg gtggtggcga acctgaccga cgcgttcgag ggctcgacga
2458981 tccgacggcg caagctgatc gggctgtcct tcggcgtggg catgggtgcg ttcgggctag
2459041 gcaccttggt cgcgtttgct ggtggcctca tcaagaaccc ctggaagccg gttgtcccca
2459101 ccgccgaggg caaaaaggcg gtgctctgga cgtcgggttg gaccccccgc taccagggcg
2459161 agacgatcta tctggcgcgc gccaccggca cggaggacgg accaccgttc atcaaaatgc
2459221 gcccggagga tatggacgcc ggtggaatgg agaccgtttt tccctggcgg gagtccgacg
2459281 gcgacggcac caccgtcgaa tcacaccata agctgcagga aatcgcgatg ggtatccgta
2459341 acccggtgat gctcatccgg atcaaaccca gtgacctggg ccgcgtggtc aagcgcaagg
2459401 gccaggagag tttcaacttc ggcgaattct tcgcgttcac caaggtctgc tctcatttgg
2459461 gttgcccgtc atcgctgtac gagcagcaga gctaccgaat cctgtgccct tgtcaccagt
2459521 cgcagttcga cgcattgcat ttcgctaagc cgatcttcgg tccagcggcc cgcgccttgg
2459581 cgcaactgcc gatcacgatc gacacggacg ggtatctggt cgccaacggt gactttgtcg
2459641 agcccgtcgg accagcattc tgggagcgaa caacaacatg agtccgaaac tgagtccgcc
2459701 gaacattggt gaggtcctgg cccgccaagc cgaagacatc gacacccggt atcacccctc
2459761 ggcggcgctg cgtcgtcagc tcaacaaggt cttcccgacc cactggtcgt tcttgctcgg
2459821 cgagatcgct ctgtacagct tcgtggtcct gctgatcacc ggcgtgtatt tgacgctgtt
2459881 tttcgatccg tccatggtcg acgtcaccta caacggtgtc tatcaaccgc tgcggggcgt
2459941 cgagatgtcg cgtgcctacc agtccgcgct ggacatttcc ttcgaggtgc gcggtggcct
2460001 gttcgtgcgc cagatccatc actgggccgc tttgatgttc gcggcggcaa tcatggtgca
2460061 cctggcacgc atctttttca ccggagcgtt ccggcggccc cgcgagacca actgggtgat
2460121 cggttcgctg ttgttgatcc tggcgatgtt cgagggctat ttcggctact cactgcctga
2460181 cgacctgctg tcgggactcg gtctgcgcgc ggcactctcg tcgatcacgc tgggtatgcc
2460241 ggtaatcggg acctggctgc actgggcgct gtttggcggt gacttccccg gcaccatctt
2460301 gatccccagg ctctacgccc tgcacatttt actgttgccg gggatcatct tggcgctgat
2460361 cgggctgcat ctggcgttgg tgtggttcca gaagcacacc cagttccccg gcccgggccg
2460421 caccgagcac aacgtcgtcg gcgtgcgggt gatgccggtg ttcgcgttca agtccggcgc
2460481 atttttcgcg gctatcgtcg gtgttctggg cctgatgggc ggcctgctgc agatcaaccc
2460541 gatctggaat ctggggccct acaagccatc acaggtgtcg gcgggctcgc agccagactt
2460601 ctacatgatg tggaccgagg gtctggcccg gatctggccg ccgtgggagt tctacttctg
2460661 gcatcacacc attcccgccc cggtctgggt cgccgtgatc atgggcctgg ttttcgtcct
2460721 gctacccgcc tacccattcc tggagaagcg gtttaccggc gactacgcgc atcacaacct
2460781 gttgcagcgg ccacgggacg ttccggtgcg caccgcgatc ggcgccatgg cgatcgcctt
2460841 ctatatggtg ctcactctcg cggcgatgaa cgacatcatc gcgttgaagt tccatatttc
2460901 gctgaatgca accacgtgga ttggccgcat cggcatggtg attctgccgc cgttcgtcta
2460961 cttcatcaca tatcggtggt gtatcggatt gcagcgcagc gatcggtcgg tgctcgagca
2461021 cggcgtcgag accggcatca tcaagcggct gccccatggc gcctacatcg agctgcatca
2461081 gcccctcggc ccggtcgacg agcatggcca cccgataccg cttcagtatc agggagcgcc
2461141 gctgcccaag cgaatgaaca agctgggctc ggccggatcg ccgggtagtg gcagttttct
2461201 gttcgccgac tccgcggcag aggatgcggc gctgcgcgag gcagggcacg ccgccgaaca
2461261 acgtgccctt gccgcactgc gcgaacacca ggacagcatc atgggttcgc cagacggcga
2461321 gcactagccc ggcgacgacc cgggtcggca cgacccggga aggaaccggg caaatcaagc
2461381 acagcccggc gacgacccgg gtcggcacga cccgggaagg aaccgggcaa atcaagcaca
2461441 gcccggcgac gacccgggtc ggcacgaccc gggaaggaac cgggcaaatc aagcacagcc
2461501 cggctaactg gactggggcg ccaccacccg gcgcagctgc cgagcgtata gccactcgat
2461561 caccggcatg cccgcggtga ccaccccggc caacccgtag ctgatccaag atggcccgtc
2461621 gtgaccgacc gccatgaggt aggtcgccgc cgccacggca atcaacgcaa tgccaatcgc
2461681 actggtcaac acgactgtcc cgcgcaacca gatccggtcc accgcctcac tggaccactc
2461741 ggcggccacc tcgaatgcat ccgcgtgctg tacgggtgcc gactcggcca cagcgcgttt
2461801 cgccggatgc ccggatccga tcgatcgccc gccccgcacg gatgcacccg tcggcctcgt
2461861 cgcgggctcg gcctcagcca tgcggcgagc tcgcaacagc accggtatcg cgcccacgat
2461921 gaccagtgcg gagaccacaa ttacggcgta cagcacccac gtggtgtgcg ggtttccggc
2461981 catctcgtgg aagcccctac ccaggtccat cagggcgaca gcggcggcca ccgacacgcc
2462041 ggtgaacacc agccacaccg cggcacatgc cccaaccagg atgcgatcga tgacgtccgg
2462101 cgagattaca tccggcccac gccggtatgc ggaatatctg ctcaccatca gcagctcgtt
2462161 tgcggtccat cgttggagtt cgatgagagc accgttccgt cgctcgtggt gatcgagcag
2462221 ttgagtttgc tgacccggaa aaggctggag gcctccaccg agccaacgtc ggattgcgag
2462281 atcggggtga ccgtcatgga ccacgggatg tacacattgt gctgtgtccg tcggcgcccg
2462341 gcggcatcga cgtaagtcac cgagataatg tcacccggcg ccttggtacc ggtcaccgaa
2462401 taggtgactt gccgcggacc ggtcggcgtg gtggtcgtgg gcggcggtgc cgccgccgtt
2462461 gtggtggtcg ccggcggcgg cgccgtggtt gtcgccggtg ggggcggtgg tggcggcgtc
2462521 acagtgaccg tctgtgtctc cgtcgctgtc gggatctcgg tggtgggcgg tggggctggt
2462581 ggcggcggtg gcggcgccgg cttggtggtc gtgatttcgt cctgcacggg cggtgcagag
2462641 gacgtagtgt cgccggtggc gagtttgctg gtatgtggtc gcgtgacgag caacgacacc
2462701 gaaaccacga gcgcaacggc ggcaattatg gcggcgacac cgaccaccca cggccagcgc
2462761 ggagcggcca gttcgtcgtc caggtcggac gactcctcat agtcgtcgta gtcatagagc
2462821 ctgagatcgg ctggcacata cgggccgccg gtgacgtgct cggattccgg ggcagagtat
2462881 gcccgagaat atgcgtcggt ctcgcccgtc tggtcactgg gcagtttgtc gccgcccccg
2462941 gcgacgggcg gcaagtggtt gccggaagcc cgttcgtcgc ccgtgtcgct gacgggttcc
2463001 gattcgggtt cgtcaggttc ccgtcccggg ggattcggcc cgctcatgtt tgcctaccct
2463061 gtccaactgc ctcaccaaca cgcgtggctt tccgcctgca tccttgcccg cgcgctcggc
2463121 gcattcttca ttggtgccac ggaaacccta cccaaccggg caggaccgag aagtctgggc
2463181 aaccgtgcta ctggtcaact gatgccctga ttgtgacctt cccggcgccg gatcagtgct
2463241 tctcaggacc gacgtaatat tcgaagacca atccggccgc cgaggcgagg atgaatgcca
2463301 caccggcggc gatcagccac gggagccaca acgcgatgcc gaccgctgcc accgagccgg
2463361 acaacgcgac catgatcggc caccagctat gcggactgaa gaatccaagt tctcctgcgc
2463421 cgtcgctgat ttcagcgcct tcgtagtcct cgggccggga atctaaccgg cgggccacaa
2463481 accggaagaa ggtggcgacg atcaacgcca tgccgccggt aagcgccagc gcagtggtgc
2463541 cagcccactc gacaccaccg gtggcgaaca tcgaggtcaa cacgccgtac agcaccgccg
2463601 tcaccacgaa gaacgcggcg acaaactcaa acagtcgggc ttcgatatgc atgagcgtcc
2463661 taacctacgg gctgcggggc caattcaccg cggcgagtat caaacgggtg ggtggtcacc
2463721 gcaaggggcg gctggttgat cgcccgcagg gcctcggcgt ttgtcttccc gtcgatgcgt
2463781 tgctgcaggt aggccttgaa atcgttgggg gtcacgacgc ggacctcgaa gttcatcatc
2463841 gagtgatacg tgccacacat ctcggcgcag tggcccacga atgctccggt cttggtgatt
2463901 tcttcgatct ggaagacgtt gaccgagttg tttgccaccg ggttaggcat cacgtcacgc
2463961 ttgaacaaga actccggcac ccagaatgcg tgtatcacat cggctgaggc catttggaat
2464021 tcgatacgct tgccggacgg cagcaccagc accggaattt cggtgctggt gcccaacgtc
2464081 tcgaccttgt cgaaattcag gtaggtccgg tcctcggtgt tgagcccgcg caccggcccg
2464141 accagctctt cgccgtactt gtccttgccc tctggcttgg aaaccatggc gcgcttgcgc
2464201 tccggatcgg caccatcata ggtcagtgtg ccgtctttga agttcaccct ttgatagcca
2464261 aacttccaat tccactggaa agacgtgata tcaatcacga cctcgggatc cttggctatc
2464321 tgcagcatct tctcctgcac cacgacggtg aaataaaaca gcaccgagat gatgaggaac
2464381 ggtatgacgg tgagaaccag ctctagcggc atgttgtagc cgaactggcg gggcaactca
2464441 gtgtcggtgt tcttcttccg gtgaaatacc gcggaccaga agatgagacc ccacacgatt
2464501 accccaaccg ccagggaggc gatcaccgcc ccgatccaca gttctcgatt gaggtgtgcc
2464561 tccggggtaa tgccctccgg ccaaccgatg cccagggctt ccgaccagct gcatccactg
2464621 acggtgacgg ccaatgcccc cagcattgct gcgagcgcca gctgtcgaag accacgggca
2464681 ggccctccgg agccgcgctg aggcctgcac tgcgacaagc gttgcaaacg acctggcccg
2464741 cgaggtgtca ctgttggcgc ctcctgtatc acaagctggg ccgactggga tagcaccggc
2464801 tgcggcgaga accatcggct aactcagaca tcgaatacta cgcagcgtag accacgccgc
2464861 ccgcgcgggc gacgatgcgg gccgaaacgg cccgctgagg agccgcgcca tcagccccgc
2464921 gggcgactgc ctggtcgtcg cgacccgccg gacgaggcat ccacaagagt cgccaagtgg
2464981 ggcatactgg ggcgccgtgt gtggactgct ggccttcgtc gcggccccgg ccggtgctgc
2465041 ggggcccgaa ggtgccgacg ctgccagcgc catcgcccgc gcatcgcatt tgatgcgcca
2465101 ccgcgggccc gatgaatcgg gcacctggca cgccgtcgat ggcgcctccg gaggcgtcgt
2465161 gttcgggttc aaccgactgt ccatcatcga catcgcgcac tcgcatcagc cgctgcggtg
2465221 ggggccgccg gaggctccgg accgctacgt gctggtgttc aacggcgaga tctacaacta
2465281 cttggagctg cgtgacgagc tgcgcaccca gcacggcgct gtgttcgcca ccgacggcga
2465341 cggtgaggcg atcctcgccg gctatcacca ctggggcacc gaggtgctgc agcggttgcg
2465401 cggcatgttc gcattcgcgc tgtgggacac cgtcacccgc gaattgttct gcgcgcgaga
2465461 tccgttcggc atcaagccgt tgtttatcgc caccggagcc ggcggcacgg cggtggccag
2465521 tgagaagaaa tgcctgctgg acctcgtcga gttggtgggg ttcgacaccg agatcgacca
2465581 tcgggcgttg cagcactaca ccgtcctgca gtacgtgccg gaacccgaga cactgcaccg
2465641 tggggtacgt cggctggaat caggctgctt cgcccggatc cgtgccgacc agctcgcgcc
2465701 ggtgatcacc cgttatttcg tgccgcgatt tgcggccagt ccgatcacca acgacaacga
2465761 ccaggcccgc tatgacgaga tcacggcagt gcttgaggac tcggtggcca agcatatgcg
2465821 cgccgatgtc accgtcggcg cgtttctgtc cgggggtatc gactccacgg ccatcgcggc
2465881 gctggccatc cggcacaatc cgcggctgat caccttcacc accggtttcg agcgcgaggg
2465941 cttctccgag atcgacgtcg cggtggcttc ggcagaggcc atcggtgccc gtcacatcgc
2466001 caaggtggtc agcgccgacg agttcgtcgc cgccctgccc gagatcgtct ggtacctcga
2466061 cgagccggtc gctgacccag cgctggtacc gttgttcttc gtcgcccgcg aggcccgaaa
2466121 gcacgtcaaa gtggtgttgt cgggcgaagg cgccgacgaa ctgttcggcg gctacacaat
2466181 ctatcgagaa ccgctgtcgt tgaggccgtt tgactacctg cccaagccac tgcgccggtc
2466241 gatgggaaaa gtttccaagc cactgccgga gggcatgcgc ggcaagagtc tgctgcaccg
2466301 cggatcgctg acactcgaag agcgctacta cggcaatgcc cgcagtttct ccggcgcgca
2466361 gctgcgcgaa gtactgcccg ggttccggcc ggactggacc cacacagatg tcacggcgcc
2466421 ggtctacgcc gaatcggccg gctgggatcc ggtggcgcga atgcagcaca tcgacctgtt
2466481 cacctggctg cgcggcgaca ttctggtcaa ggccgacaag ataacgatgg ccaactccct
2466541 ggagctgcgg gtgccgttcc tggacccgga ggttttcgcg gtggcctccc ggttgccggc
2466601 gggcgccaag atcacccgta ccaccaccaa gtacgcgctg cggcgcgcgc tggagcctat
2466661 tgtgcccgca cacgtgctgc accggcccaa gctcgggttc ccggtcccga tccggcattg
2466721 gctgcgtgcc ggcgagctgc tggagtgggc gtatgcgacg gtgggctcgt cgcaggccgg
2466781 tcacttggtt gacatcgccg ccgtgtatcg catgctcgac gagcaccggt gcggcagcag
2466841 cgaccacagc cgccggctgt ggaccatgct gatctttatg ctgtggcacg cgatcttcgt
2466901 cgagcacagc gtggtgcccc agatcagcga gccgcagtac cccgtccagt tgtaaccgcc
2466961 ccttcgcgag cagacgcgga atcgcatcgg cggggcccac acggtgcgat tccgcgtctg
2467021 ctcggcggtg ccgcggctag gccaagccgc ggctaggcca gcacggcgac gatctcggcg
2467081 gccgcgtgct cgccgtaagc accagccagc ctgctggccg cggcctcgta gtcccactgc
2467141 cactcctgag ttccggtcga ctccagcacc agcacggcaa ccagcgagcc cagctgcgcc
2467201 gaacgctcca ggcctagtcc ggcactgcgg ccagtcagga aaccggcgcg gaacgcgtcg
2467261 ccgacgccgg tggggtcggt ctggctggtt tcggggacca cgccgacgtg gatggtggtg
2467321 ccgtcaggtt ctaccaaatc gacaccctta ggacccaatg tggtcacccg caggtcgatc
2467381 tgcgccatca catcggcctc tgaccagccg gtcttggaca gcagcagatc ccattcgtag
2467441 tcgttggtga acaagtaagc agcaccgttg acgagcctgc gaatttcctc acccgacagc
2467501 ctcgccagct gctgagacgg atcggcggcg aaggccagcc ccagcttgcg acactcctcg
2467561 gtgtgcaaga acatcgcctc ggggtcgttg gcgccgatga tcaccaactc cggcttgccg
2467621 atggccgaca ccacgtcggc aagcttgatg ttacgtgcct ccgacatagc cccggggtag
2467681 aacgatgcga tctgggccat gtcgacatcg gtggtacagg taaaccgcgc cgtgtgcgcg
2467741 gtctcggaga tcagaacgtg gtcgcagttg acaccgcggg ctttcagcca gtcgcgataa
2467801 tcggcgaagt cggcgcctgc cgccccaact agcgcgacct cgccacctag cacaccgatg
2467861 gcgaaggcca tgtttccggc cacgccgccg cggtgcatca ccaagtcatc gactaggaag
2467921 ctaagcgaca ccttgtgcag gtgttcgggc agtagctgct cggaaaatcg gcctggaaac
2467981 cgcatcaaat ggtcggtcgc aatcgaaccg gttaccgcga tcgtcacaaa atctccgtcc
2468041 ttcgttccta aggttgccta gtctttcaac attatcggcg ccgcggcccg ccccgtcgcg
2468101 ttgagagctg acggcagctg ttgcgctagc ctgcctaggg agctcacctg attgccgatg
2468161 ctgccggctg acgcgacggg cggttgtcgc cctagcagct ggtcccgtcc accaccctag
2468221 gagaaccaca atgcccggtc cccactcgcc gaaccccggt gtcggcacca acggaccggc
2468281 gccgtacccc gagccctcat cccacgaacc ccaagccctg gactaccccc acgacctcgg
2468341 cgccgccgaa ccggccttcg ccccgggacc ggcagacgac gcggcgctgc cgcccgccgc
2468401 atatcccggc gtgccgccgc aggtgtccta cccgaagcga cggcacaagc ggctgctgat
2468461 cggcattgtg gtagccctcg cgctggtgtc ggctatgacg gcggcgatca tatacggggt
2468521 ccgcaccaac ggagccaaca cggcaggcac attctcggag ggaccggcca aaaccgcgat
2468581 tcagggatac ctcaacgcgc tggagaaccg cgatgtggac accatcgttc gcaatgcgct
2468641 gtgcggtatc cacgacggcg tgcgcgacaa gcgctccgat caggccttgg ccaagctgag
2468701 cagcgacgcg ttccgcaagc agttctccca ggtcgaagtg acctcgatcg acaaaatcgt
2468761 gtactggtcg caatatcagg cccaggtgct gttcaccatg caggtgacac ctgccgccgg
2468821 cggcccgcca cgcggtcagg tgcaaggcat cgctcagttg cttttccagc gcggtcaggt
2468881 cttggtgtgc tcgtacgtgt tgcgcaccgc ggggtcgtac tagcgtttta tcagttgaac
2468941 gaatccccgc acgcgcagga gccggtggcg ttgggattgt cgatggtgaa gccttgcttc
2469001 tcaatagtgt cgacgaaatc gatcgacgcg ccttccacat acggcgcgct catccggtcc
2469061 acgatcaacc tgacaccacc gaactccgcg gtttggtcac catccagcgt ccggtcgtcg
2469121 aagaaaaggt tatagcgcaa tccagcgcac ccccccggct gaaccgcgat ccgcagcgcc
2469181 agatcgtccc gtccctcctg gtccaacagc gacttcgcct tggcggcggc cgcttcggtc
2469241 aggatcacgc cgtgggtctt ggcgctcggc tcgttctgca ccgtcatgac ttctcctaga
2469301 tgtctcatcg ttgggtgggc cccgcccact agcgtttcag cctgcggaat ccagtctggg
2469361 gtctgcttgg ggaaaatccc acttcctcaa cggtaccctg aaggaccgct attcccgagt
2469421 cgcgccgcta cctgagacgc caagcccatg agctgattgg ccgcatcggc cagcgccaac
2469481 cgcaccgaac cggcgtactc agcgatggac aatgcggcca taatgcccgc cgaccgcaac
2469541 gcggacttgt ccagcgacac ctggccggcc aacactatca ccggaattgc gagcgggcgg
2469601 gccgcagccg cgatcgcacc aaccaccttc ccgtgcaggg attgctcgtc gaatcggccc
2469661 tcaccggtga cgatcagctc cgcatcggca aggtcgtcgg caaaatgcgt gtgctctgcg
2469721 atgattgccg cacccgactg gtaccggccg ccaaccgcga gcagcccagc cccgatacca
2469781 ccggcggcgc ccgcgcccgg ctcggcgctc accccgcgcc cggcggccgc gtccagttca
2469841 atcgcccatg ccgccagacg gccttccaac actgcgacgg tggccatgtc cgcgcccttc
2469901 tgcggcgcga acaccctggc cgtgccccat ggtcccagca atgggtattc gacatccgag
2469961 gcggcgatca cctcgacgtc ggccaactgt cggcgggccg cgtccaggcc gccaagctcg
2470021 gcaatcatcc ccttcccccc gtcggtacat gcgctgcccc ccaaccccac cacgatccga
2470081 gccgccccgg cccgcagtgc cgcggcgatg agctggccga cgcccttgct gtgggccgcc
2470141 agcgcggtct cgggcgtggg cgggccgcca agcaacccca gaccacaagc ctgcgcacac
2470201 tccaaatacg cggttgccga gcccggatcg aacacccacg ccgcgttcac gacggtgttc
2470261 agtggcccgc aaacacgcag ccggcgggtc tctcctagcc ggctgcccag cacctcaaca
2470321 aaacccggac cgccatcgga ttggggggcg acgatgaacg aatcgcctgg tcgcgaccgc
2470381 gtccagccgg tcgcaatggc cgcggcggcc tccaccgcag acaggctgtc gccgtagcag
2470441 tccggtgcca ccaacacccg catggcgggc agctggagtc ggccgggccc caagctaccg
2470501 gtcgcgtcat ccgaggcctg cgagcctttc atcactggcc agagtaggtc tgcgcaccca
2470561 cacgcgtacc taaacgcacg caaattccaa acgggccccg ccgcgaagta gcctggcgac
2470621 tgtgaagctg ctgggccacc ggaagagcca tggacaccaa agggccgacg catcacccga
2470681 tgccgggtcg aaagatggtt gccggcctga ttccggacgc acgtccgggt cggacacatc
2470741 gcgcgggtcg caaaccaccg gccccaaggg ccggcccacg cccaagcgca accaatcccg
2470801 tcgccacacc aagaagggcc cggtcgcacc ggcaccaatg actgcggccc aggcacgggc
2470861 ccggcgcaag tcgcttgccg gccccaaact tagccgcgag gaacggagag ccgaaaaggc
2470921 cgcaaaccgg gcccggatga cggaacgccg ggaacgcatg atggccggcg aagaggccta
2470981 cctgctcccg cgcgaccggg gcccggtacg ccgctacgtg cgcgatgtgg tggactcccg
2471041 gcgcaacctg ctcgggctgt tcatgccctc ggcgttgacc ctgctgttcg tcatgtttgc
2471101 cgtgccgcag gtgcagtttt acttgtctcc ggcgatgttg atactgctgg ccttgatgac
2471161 gatcgacgcg atcatcttgg gtcgcaaagt tggccggctg gttgacacga agttcccgtc
2471221 taacaccgaa agccggtgga ggctgggtct ttacgccgcc ggccgagctt cccagatacg
2471281 ccggttgcgg gcgccccgac cccaagtcga gcgcggcggc gatgttggct aacggacgcc
2471341 ggaagtcatc tcacccggtg tacaccctag tgctcagcgg gcggaccgaa ccgatcaagc
2471401 cggcgaaagg atgatcggct tcgcgccggt gtcgacgccc gatgcggctg ccgaagcagc
2471461 cgcccgcgcc cgacaagaca gcttgaccaa gccgcgggga gcgctgggca gtctcgagga
2471521 cctgtctgtc tgggtcgcgt cgtgccagca gcgctgtccg ccgcggcaat tcgagcgcgc
2471581 ccgggtggtg gtgttcgccg gtgaccatgg tgtggcccgg tccggggtgt cggcgtaccc
2471641 gccggaagtc accgcccaga tggtcgccaa catcgacgct ggcggggcgg cgatcaacgc
2471701 gctggccgat gtcgcgggcg cgaccgtgcg ggtcgcggac ctggccgtgg acgcggaccc
2471761 gctgtctgag cgcatcggcg cgcacaaggt gcgccgcggc agcggcaata tcgccaccga
2471821 ggacgcgttg accaacgacg agaccgccgc cgcgatcaca gccggccagc agatcgccga
2471881 cgaagaggtt gatgccggcg ccgacttgct catagccggc gatatgggaa tcggaaacac
2471941 taccgcggcc gcggttcttg tggcggcgct gaccgatgcc gagccggtcg cggtggtcgg
2472001 gttcgggacc ggtatcgacg acgccggttg ggcgcgtaag acggccgcgg tgcgcgacgc
2472061 cctgtttcgg gtgcgcccag tgttgcccga cccggtcggg ttgctgcgct gcgccggcgg
2472121 cgctgacttg gccgcgatag ctggcttctg cgcgcaggcc gcggtccgac gcaccccgct
2472181 gctgcttgac ggggtggcgg tgacagccgc cgccctggtc gctgagcgtc ttgcgcccgg
2472241 cgctcaccgg tggtggcagg cgggtcatcg atccagcgaa ccgggccacg ggctggcgct
2472301 ggcagccctc gggctggacc cgatcgtgga ccttcacatg cggctgggcg agggaaccgg
2472361 cgccgcggtg gcgttgatgg tgttgcgcgc cgcggtcgcg gcgctgtcgt cgatggcgac
2472421 cttcaccgag gccggcgtgt ccacccggtc cgtcgacggt gtcgaccgga ccgcaccccc
2472481 ggcagtctca ccgtgatgcg ttcgctggca acagctttcg cattcgcaac ggtgataccc
2472541 acaccgggct cagcgaccac cccgatgggc cgtggcccga tgaccgcgct gccggtggtg
2472601 ggcgcggcgc tgggtgcact ggcggcggcg atcgcatggg ctggcgcgca agtgttcggc
2472661 ccgtccagcc cgctgtccgg catgctcacg gtggcggtac tgctggtcgt cactcgaggc
2472721 ctgcacatcg atggcgttgc cgataccgct gacggactgg gctgctatgg gccgccgcag
2472781 cgtgcgcttg cggtgatgcg cgacgggtcg accggaccgt tcggggtggc ggccgtggtc
2472841 ttggtcatcg ccttgcaggg cctggccttc gcgaccctca ccacggtcgg gatcgctggg
2472901 atcacgctgg cggtcttatc cggccgggtc accgccgtac tggtctgtcg ccggttggtg
2472961 ccggcagccc acggcagcac cctgggctcg cgggtcgccg gtacgcaacc cgcgccggtg
2473021 gtggcggcct ggctcgccgt cctgctcgcc gtttcggtgc cggccggtcc ccggccttgg
2473081 caaggaccga tagcggttct ggtagcggtg acggccggcg cggccctggc ggcgcattgc
2473141 gtgcaccggt tcggcggtgt caccggtgac gtgctgggca gcgcgatcga gctgagcacg
2473201 acggtcagcg ccgtgacgct tgcgggcttg gcccggcttt agcaggcggc gagcgggacg
2473261 ctgcagtaga ctcatgtccg ccgtcccttc caacacaggg ctcccctccg tgtccccaga
2473321 ttaggggaca tgaaattcaa ccgacggtgt ccgattggcg gatcgttttg gccgcgcggc
2473381 atatatagcg tcgttaatca tgcccgcatc acgactggtc agacaagtgt ctgcgccacg
2473441 gaacctgttc gggcggctgg ttgcccaggg gggcttctac acggccgggc tgcagttggg
2473501 cagcggtgcg gtggtactgc cggtcatctg cgcacatcag ggcctcacct gggcggctgg
2473561 gctgttgtat ccggcgttct gcattggcgc cattctggga aattcgctgt cgccgctgat
2473621 tctgcagcgc gccggccagc tccggcacct gctgatggcg gcgatatcgg cgacggcggc
2473681 ggcgctggtt gtgtgcaacg ctgcggtccc ctggactggc gttggcgtcg ccgcggtttt
2473741 tttggcgacc acgggggccg gtggtgtcgt caccggagtc tccagcgtcg cctacaccga
2473801 catgatctcc agcatgttgc ccgcggtacg gcggggcgag ctactgctca cccaaggtgc
2473861 cgcggggtcg gtgctggcca ccggcgtcac attggtgatt gtgccgatgc tggcccatgg
2473921 caacgagatg gcgcgctatc acgatctgct gtggctgggc gccgcaggtc tggtttgctc
2473981 cggcatcgcg gcgctgttcg tcggcccgat gcggtctgtg tccgtcacaa ccgccacccg
2474041 aatgccactg cgggaaatct attggatggg cttcgcgatc gcccgctccc agccgtggtt
2474101 tcgccggtat atgacgactt acctgctgtt cgttccgatc agcctgggca ccacgttctt
2474161 cagcctgcgc gccgcccagt ccaacggcag tctgcacgtg ctggtgatcc tttccagcat
2474221 tggattggtc gtcggttcga tgctgtggcg acagataaac cgcctgttcg gggtgcgtgg
2474281 cctgctgctg ggcagcgcac tgctcaacgc cgctgctgcg ctgctgtgca tggtggccga
2474341 gtcgtgtggg cagtgggttc acgcctgggc gtacggcacg gcgttcctgc tggctacggt
2474401 ggccgctcaa acggtggtcg ccgcatcgat atcgtggatc agcgtcctcg cgcccgagcg
2474461 gtaccgcgcc accctgatct gcgttgggtc gaccttggcc gccgtcgaag ccaccgtgct
2474521 gggagttgcg ctcggcggaa ttgcccaaaa gcatgccacc atctggccgg ttgtcgtcgt
2474581 gctgacactg gccgtaatcg ccgcggtggc gagtctgcgc gcaccgacac gaatcggggt
2474641 gacggcggac acgagcccgc aagcagcgac cttgcaagcc taccgcccgg ccactcctaa
2474701 ccccatccat agcgatgaac gttcgacgcc gcccgaccat ctctcagtcc gccgcgggca
2474761 gttacgacac gtatgggaca gtcgccggcc cgcgccaccc ctgaaccggc caagctgtcg
2474821 ccgcgcggcc cgccgtccag cgcccggcaa acccgctgcc gcactacccc agccgcgcca
2474881 tccagccgtg ggtgtccgcg aaggtgcccc gctggatgcc ggtcagcgta tcgcgtagtg
2474941 ccatggtcac ctcacccggc tgaccgtcgg cgattctgaa ctcgctggca ccgtgccgca
2475001 cccgcgcgac cggggtgatg acagcggcgg tgccgcacgc aaacacctcg gtgatctcgc
2475061 cggcggcggc tttcttctgc cactcgtcga tatcaatcct gcgttcctcg accgcgaatc
2475121 cggcatcaat agccaactgc aacaacgaat cccgtgtgat cccgggcagc agggaaccgg
2475181 acagctccgg ggtgaccagc cgcgccgatc cgccgctgcc gagcacgaag aagatgttca
2475241 tgccacccat ctcttcgata tagcggcgtt ccacagcgtc cagccacacc acctggtcgc
2475301 atccgttctc ggcggcttcg gcctgcgcca gcaacgaggc ggcgtagttg ccgccgaact
2475361 tggccgcacc ggtgccgccc ggacaggccc gtacatactc cgtcgaaacc cagacgctga
2475421 caggggcgat gccgcccttg aagtacgcac cggccggcga ggcgatcaac aggtaacggt
2475481 attgggtggc aggccgcacg cccagtcccg gctcggtggc gaagatgaac ggccgcagat
2475541 acagcgcctc ctcaccgccg gcaccgggca cccaagcttt gtcgacagcg attagctggc
2475601 gcagggattc gatgaacacc gcgtcgggca gttcgggaat cgccaaccgc cgcgccgacg
2475661 aacgcaacct ggcggcgttg gcgtcggcgc gaaacgacac gatggacccg tcggcccagc
2475721 ggtaggcttt gagcccttcg aacacctcct gcgcatagtg cagcacgatc gccgagggat
2475781 ccagctcgat cgggccataa gggattaccc gcgcgttgtg ccaaccacgg ccctcggcat
2475841 agtcgatcga caccatatgg tcggtgtggt atttgccgaa acccggctcc cgcagcatcg
2475901 attcacgctg cgcgtcggtg gccggattga ccgcacgtaa caccgtgaat tgaagggagc
2475961 cgctggtcat gggccgattc tatccgtggg cgaacggtta ttgacggccc ggaggccact
2476021 ccgctgccac caagtggtga ctcagcgcgt tttcacggca acgaacggcg gacacaccac
2476081 ttgacattcg acagcacggc cgcggacgtc gacattgatt tgctggccgt cttcgatgcc
2476141 ggcatcactg tcgatcagcg ccagcccgat gccgacctgc aacgtgggag aaaacgttcc
2476201 cgacgtggtg accccaaccg tctcatcccc gacaagcaca gccagcccgg ggcgcagcac
2476261 accgcgaccg accatgcgca gcccccgcag cagccgccgc ggcccggccg ctttctcggc
2476321 caacaacgcc gcacgaccaa agaaggcgtc cttccgccag ccgaccgccc agccgcatcg
2476381 ggcctgcagc ggcgagatgt ccagcgaaag ctcgtgcccg tgcagcggat agcccatttc
2476441 agtgcgcagt gtgtcgcgag caccgaggcc ggcgggctcg ccgcccgcgg ctgataccgc
2476501 cgccaacagt gcgtcgaaca ccacacccgc cgactcccat ggcggcagca gttcgtaacc
2476561 gtgctcaccg gtgtagccgg tgcgacagac acgcaccggc acccccgagt acgaagcgtc
2476621 ggcgtagccc atgtagtcca tctcggttgg cagccccaac gcggtgagca cgtcggtcga
2476681 acacggcccc tgtacggcca gcaccgcgta ggaccgatgc agattggtga tgctcagacc
2476741 gcccggtgcg gcagcttgta gcgcgccgac caccgcggcg gtattggcgg cgttgggcac
2476801 cagaaagatc tcgtcgtcgc tgacgtagta ggcgatcagg tcgtcgatca caccgccgga
2476861 ttcggtgcag cacaaggtgt attgcgcctt gccgggcccg atacgaccca ggtcgttggt
2476921 gagcgcggag ttgacgaact gcgccgcacc cggtccacgg accagtgcct tgcccaggtg
2476981 gctgacgtcg aaaaggccga cggcggtgcg ggtggcgttg tgctcgctga cggttccggc
2477041 atacgagacc ggcatcagcc agccgccgaa ctcggcgaaa ctcgcaccca gctcgcgatg
2477101 gcggtcttcc agcggtccgt gtatcagctc tggcacatcg ctcacggcgt cccaccctaa
2477161 tgggcgtccc tgctggcaca cttaggcagg tgtacgattc cttggacttc gacgccctcg
2477221 aggccgccgg aattgccaac ccacgcgagc gggccggctt gctcacctac ctggatgagc
2477281 ttggcttcac ggtcgaagag atggtgcaag ccgaacgccg cggccggttg ttcgggctgg
2477341 ccggtgacgt cctgctatgg tccgggcccc cgatctacac cctggcgacc gcggctgacg
2477401 aactggggtt gtcagccgac gacgtcgcac gcgcgtggag tttgctcggc ctcaccgtcg
2477461 cgggtcccga cgttcccacg ctgagccagg ccgacgtcga cgccctggcg acctgggtcg
2477521 cactgaaggc gctggtgggt gaggacggcg cattcggcct gctgcgagtg ctcggcactg
2477581 ccatggcccg actcgccgag gccgagtcga ccatgatccg cgccgggtca ccgaacatcc
2477641 aaatgacgca cacccacgac gaacttgcca cggcacgggc ctatcgcgcg gctgcggagt
2477701 tcgtcccccg gatcggtgcg ctgatcgaca ccgtccaccg tcaccacctg gccagcgcac
2477761 gaacctactt tgaaggcgtc attggcgaca cgtcggcaag cgtgacgtgc ggtatcggct
2477821 ttgcggatct gtccagcttc accgcgttga cccaggcgct cacccccgcg cagttgcagg
2477881 acctgctcac cgaattcgac gccgccgtca ccgacgtggt gcatgccgac ggtggccggt
2477941 tggtgaagtt catcggcgac gccgtgatgt gggtgagctc gtcgcccgaa cgactggtgc
2478001 gggcggcggt ggatctcgtc gatcatccgg gtgcgcgcgc ggccgaactg caggtccgtg
2478061 ccggtcttgc ctatggcacg gtgctggccc ttaacggtga ctacttcggc aacccggtca
2478121 acctggctgc gcgcctggtg gcggccgcag cgccagggca gatcctggcc gcagcgcaac
2478181 tccgcgacat gttgccagac tggcctgccc tcgcccatgg cccattgacg ctcaaggggt
2478241 ttgacgcccc ggtgatggcc ttcgaactgc acgacaaccc tcgtgcgagg gatgctgaca
2478301 cgccaagccc cgccgccagt gattagggtg gttgcccgtg accaccgaac cgggttacct
2478361 atccccctcc gtcgccgtcg cgacctcgat gccgaaacgt ggtgtcggcg ctgcggtgtt
2478421 gatcgtgccg gtcgtctcga ccggcgaaga ggatcggccc ggcgcggtcg ttgcctcggc
2478481 cgagcccttc ctgcgcgccg acacggttgc cgaaatcgag gcgggcctgc gagcgctgga
2478541 cgccaccggc gccagtgacc aggtgcaccg gctggcggtg ccgtcgttgc cggtgggcag
2478601 cgtcctgacg gtcggcctgg gcaaaccgcg gcgcgaatgg ccggccgata ccatccgctg
2478661 cgccgccggc gtggccgcgc gtgcgctcaa cagttcggag gcagtgatca ccacgctagc
2478721 cgaattacct ggcgacggca tctgctcggc caccgtcgag gggctgatcc tgggcagcta
2478781 ccgattcagc gccttccgca gcgacaagac cgcgcccaaa gacgccggac tccgcaaaat
2478841 caccgtgctc tgctgtgcaa aggacgccaa gaagcgcgcg ttgcacggtg cggccgtcgc
2478901 gaccgcggtg gccaccgccc gggacttggt caacactccc ccaagccacc tgtttcccgc
2478961 cgagttcgct aagcgcgcaa agactttgag cgaatctgtc ggcctcgacg tggaagttat
2479021 cgacgaaaag gcgctgaaga aggccggcta tggcggggtg attggtgtcg gccagggctc
2479081 gtcgcggccg ccgcgactgg tgcggttgat tcatcgggga tcgcggctgg ccaagaaccc
2479141 ccaaaaggcc aagaaggtgg ccttggttgg caaggggatc accttcgata ccggcggcat
2479201 ctcgatcaag ccggcagcgt cgatgcacca catgacctcg gacatgggcg gagcggccgc
2479261 ggtgatcgcc actgtcacgc tggctgcccg gctgcgactg ccgattgacg tgatcgccac
2479321 ggtgccgatg gccgagaaca tgccgtcggc gacggcgcag cgcccgggcg acgtgctgac
2479381 ccaatacggt gggaccaccg tcgaggtgct caacaccgac gcggagggcc ggttgatcct
2479441 ggccgacgcc atcgtccggg catgtgagga caagccggac tatctgatcg agacatccac
2479501 gttgaccggt gcgcaaacgg tggcgctggg gacgcgcata ccgggtgtga tgggcagcga
2479561 cgagttccgc gaccgggtcg ccgcgatctc gcagcgggtg ggcgagaacg gctggccgat
2479621 gccgctgccc gatgacctca aggatgactt gaaatccacg gtggccgacc tggccaatgt
2479681 gagtggccag cgtttcgcag gcatgctggt ggccggggtt ttcctgcgtg agttcgtcgc
2479741 cgaatcggtg gattgggcgc acatcgacgt ggccggcccg gcctacaaca ccggcagcgc
2479801 ctggggttac acgcccaagg gcgccaccgg tgtgcccacc cgcaccatgt tcgcggtgct
2479861 cgaggacatc gcgaagaacg ggtaggcggc cgcccggacc caaagcactt cacgagtagc
2479921 ggttagatca cccgcagccg cgcggtactg cgcagcgcct gcggcagcac ccgggagatg
2479981 ccgtatagcg cataggcttc cggcgcgacc ggtctgatcg gcttcttctt cttgaccgcg
2480041 gacacgatcg cgtcggctac cttgtccggc ccgtagctgc gcagcgcaaa catcttgtcg
2480101 atctgccccc gccggccgtc gatcttctcc tcgtcggttc cgggcgcgtg gaaaccggtg
2480161 gtagcgacga tgttggtgtc aatgacaccg gggcagatgg tggtcagtcc gacaccggcg
2480221 gcatcgagtt cggcccgcaa acagtcggag aacatgtagg tcgccgcttt ggaggtgcag
2480281 tacgcgctga gcgactgcag cggcgcatag gcggccatcg acgacacgtt gacgatgtgc
2480341 ccgccagtcc cccgctcgac cagacgctgc ccaaaagcgc ggcaaccgtt caccacgccg
2480401 cccaggttga cggccagcac ccggtcgaac tgctcagccg gggtgtccag gaaccgaccc
2480461 gcctggccga tgccggcgtt gttgacgaca atgtcgggga ccccgtgttc ggcgctgacc
2480521 cgctcggcga atgcctcgac cgcctcggcg tcggacacgt cgagcacata ggggtacgcg
2480581 atgccaccac gtgcggcgat ctcggcggcg gtgtccttga cggtggcctc gtcgatgtcg
2480641 ctgataacga tctctgcacc ctcacgagca aaggcgagcg cggtctcgcg gccgattccg
2480701 ctgcccgccc cggtaaccga caccagcgtg tcaccgaagt acccgcgggg ccgtccgacc
2480761 tgggcgcgta acagcgcgcg gctcggctgc ttgccgtcgg ccaggtcggc gaagtcgtgc
2480821 acggcggccg ccatcacctg cgggtgcgac atcggcgaaa agtgaccagc tttgatgtca
2480881 cgccgccaga gccgcggcac ccagcgcgcc gtctggtcgt atccgtaggg ccgcacgtag
2480941 gggtcctggg aattgacgat cagctgcacc ggcacatcaa ctatcggaat ggcccggccg
2481001 cggcggctgc tggaaaacga ccgaaagtag tttgcggggt aagtcttgac cgagtgggcg
2481061 gcatcacggg ccagcgtctc cgagtgatga atctggtcga cgggaatgtc gccgaccatg
2481121 ttgcggcgga cggccgcact cgacagcgca acccgaagca gcagcggtgc gaccaccggt
2481181 accgagaaca aggccatgta gctcaaccgc agtgtctggc tgatcgcccg tagaaaggtt
2481241 cgcggacgcc aaggccgccg cagaccgcca taaacgtagt tgaccaggtg gtcttgactg
2481301 gggccggaca ccgacgtgaa cgaggcgacc cgatcactgg ctccgggccg gcgcaggtac
2481361 tcccacaccc ccaccgaacc ccagtcatgg gccagcacgt gcaccggctc accggggctc
2481421 agctcgccga tgacggcgtc gaaatcgtcg gcgaaatggg ccatggtgta ggccgaaatg
2481481 ggtttgggca ccgatgagcg accgacacca cggttgtcgt agcgaacgat ccggaaccgt
2481541 tcggccagca gcggaacgac accgtcccac agcacgtgcg agtccggaaa gccatgcacc
2481601 agcacgacgg tcgggccgtc gggattgcct tcgtggtaga ccgcgatgcg aacgccatcc
2481661 gggctgtcga ccagacggga catctgttgt gttgccggca tcgcacctcc gcccaccggg
2481721 acttgctgtt gcaaccagtc gcccaaaccg tagcaaggac ggccgactgc accgatgtcc
2481781 ccgccgaggt gtcggcaacg gccgccgggg ccaccaactc gccgcgccct ggatgtgtgt
2481841 cgctccgggc gcagtgacag gataggtttc gacatccacc tgggttccgc acccggtgcg
2481901 cgaccgtgtg ataggccaga ggtggacctg cgccgaccga cgatcgatcg aggagtcaac
2481961 agaaatggcc ttctccgtcc agatgccggc actcggtgag agcgtcaccg aggggacggt
2482021 tacccgctgg ctcaaacagg aaggcgacac ggtcgaactc gacgagcccc tcgtggaggt
2482081 gtcgaccgac aaggtcgaca ccgaaatccc ctcgccggcc gcgggtgtgc tgaccaagat
2482141 catcgcccag gaggatgaca cggtcgaggt cggcggcgag ctcgctgtca ttggcgacgc
2482201 caaggatgcc ggcgaggccg cggccccggc acccgagaaa gtccctgcgg cccaacccga
2482261 gtccaagccg gcacccgaac caccaccggt ccaaccgacg tccggagcgc ctgctggtgg
2482321 cgatgccaag ccggtgctga tgcccgagct cggcgaatcg gtgaccgagg ggaccgtcat
2482381 tcgttggctg aagaagatcg gggattcggt tcaggttgac gagccactcg tggaggtgtc
2482441 caccgacaag gtggacaccg agatcccgtc cccggtggct ggggtcttgg tcagtatcag
2482501 cgccgacgag gacgccacgg tgcccgtcgg cggcgagttg gcccggatcg gtgtcgctgc
2482561 cgacatcggc gccgcgcccg cccccaagcc cgcacccaag cccgtccccg agccagcgcc
2482621 gacgccgaag gccgaacccg caccatcgcc gccggcggcc cagccagccg gtgcggccga
2482681 gggcgcaccg tacgtgacgc cgctggtgcg aaagctggcg tcggaaaaca acatcgacct
2482741 cgccggggtg accggcaccg gagtgggtgg tcgcatccgc aaacaggatg tgctggccgc
2482801 ggctgagcaa aagaagcggg cgaaagcacc ggcgccggcc gcccaggccg ccgccgcgcc
2482861 ggccccgaaa gcgccgcctg cccctgcgcc ggcgttggca catctacggg gcaccaccca
2482921 gaaggccagc cggattcgtc agatcaccgc caacaagacc cgcgaatctt tgcaggcaac
2482981 ggcacagctg acacaaaccc atgaggtcga catgaccaag atcgtggggc tacgggcccg
2483041 ggccaaggcg gcgttcgccg agcgtgaggg cgtgaacctg accttcctgc cgttcttcgc
2483101 caaggccgtg atcgatgccc tcaagattca cccgaacatc aacgctagct acaacgagga
2483161 caccaaggag atcacctact acgacgccga gcacctagga ttcgctgtcg acaccgagca
2483221 gggcctgctc tccccggtca tccacgacgc cggcgatctg tcactggccg gtctggcgcg
2483281 ggcgatcgcc gatatcgcgg cccgtgcccg gtcgggcaac ctgaaacccg acgagttgtc
2483341 cggcggcacc ttcaccatca ccaacatcgg tagccagggc gcgttgttcg acaccccgat
2483401 cctggttccg ccgcaggccg ccatgctggg caccggggcg atcgtcaagc ggccgcgggt
2483461 ggtcgtcgat gccagcggca acgagtcgat cggggtgcgc tcggtctgct acctcccgtt
2483521 gacctatgac catcggctca tcgacggcgc cgacgccgga cgtttcctca ccacgatcaa
2483581 gcaccgcctc gaagagggag cgttcgaggc cgatttagga ctgtgatggc caacgccgtt
2483641 gtcgcgatcg cgggttcgtc tggcttgatc ggctctgccc tgaccgcggc gctgcgcgcg
2483701 gccgaccaca cggtgctgcg gatcgtgcgc cgggcacctg cgaattccga agaactgcac
2483761 tggaatcccg aaagcggcga attcgatccg cacgcgctca ccgatgtcga cgccgtggtc
2483821 aacctctgcg gcgtcaacat cgcccagcgt cggtggtcgg gggctttcaa acagagcctg
2483881 cgcgacagcc ggatcacacc caccgaggtg ctatccgccg cagtcgccga cgccggcgtc
2483941 gctaccttga tcaacgccag cgcggtgggc tactacggaa acaccaagga ccgggtggtc
2484001 gacgaaaacg actcggcggg aacaggtttt ctggcccagc tgtgcgttga ctgggaaacc
2484061 gccacgcggc cggcgcagca gagcggtgcc cgcgtggtgc tggcccggac cggagtggtg
2484121 ctgtctccgg cggggggcat gctgcgacgc atgcggccac tgttttcggt gggcctgggc
2484181 gcgcggctgg gcagcggccg gcaatatatg tcatggatca gcctggagga cgaggtgcgg
2484241 gcgctgcagt tcgctatcgc gcagcccaac ctgtccggcc cggtgaactt gaccgggccg
2484301 gcccccgtta ccaacgccga attcaccacc gcgtttggcc gcgccgtcaa ccgccctacc
2484361 ccgctgatgt tgcctagcgt cgcggtacgc gcggcgtttg gtgagttcgc cgacgagggg
2484421 ttgctcattg gtcagcgcgc catcccctcc gcgctggagc gagccggatt tcagttccac
2484481 cacaacacca ttggcgaggc gctcggctac gccaccaccc ggcccggcta ggcttgaccc
2484541 cgtctgccca gccgtgcgct ggcggccgag tagcctagct atcgtgacgg gttctatccg
2484601 gtcgaagctg tccgcgatcg acgtccgcca gctggggacc gtcgactacc ggaccgcgtg
2484661 gcagctacag cgagagctag ccgacgcccg ggtcgccggc ggcgccgaca cgctgctgct
2484721 gttggaacac cccgcggtct acaccgccgg acggcgtacc gagacacacg agcgacccat
2484781 tgacggcact ccggtcgtcg acaccgaccg cggcggcaag atcacctggc acggtccggg
2484841 gcaattggtc ggctacccga tcatcgggct ggccgaaccc ctcgacgtgg tcaattacgt
2484901 tcggcgcctt gaagaatcgc tgatccaagt ctgcgccgat ctgggcctgc acgccggccg
2484961 cgtcgacggc cggtccgggg tctggctgcc cggcaggccg gcgcgcaagg tcgcggccat
2485021 cggtgtccgg gtgtcgcggg cgacgacact gcacgggttt gcgctcaact gcgattgtga
2485081 tttggctgcc ttcaccgcca tcgtgccatg cggaatcagt gacgccgcag tgacatcgct
2485141 gtccgccgaa ctcggccgta cggtcaccgt cgacgaggtc cgcgcgacgg tcgccgccgc
2485201 tgtctgcgcc gctctggacg gcgtcctacc ggtcggtgac cgcgtgccct cacacgccgt
2485261 accatcgccg ttatgagtgt cgctgccgag ggccggcgcc tgttacgcct ggaggtgcgc
2485321 aacgcgcaga ccccaatcga gcgcaaaccg ccgtggatca agacacgagc ccgcatcggg
2485381 ccggagtaca ccgagctgaa gaacctggtc cgccgcgagg ggctgcacac ggtctgcgag
2485441 gaggccggct gccccaacat cttcgaatgc tgggaggacc gagaagccac cttcctgatc
2485501 ggcggtgacc agtgcacccg ccgatgcgat ttctgccaga tcgacaccgg aaagcccgcc
2485561 gagctggacc gcgacgagcc acgccgagtc gccgacagcg tgcgcacgat gggcctgcgc
2485621 tatgccaccg tcaccggcgt ggctcgcgac gacctgcctg acggcggggc ctggctgtac
2485681 gccgcgaccg tgcgcgccat caaggaactc aatccgtcga ccggcgtcga actgctgatt
2485741 cccgacttca acggcgaacc aacccggctg gccgaggtct tcgagtccgg cccggaagtc
2485801 ctggcacaca atgtcgaaac cgtgccccgt atcttcaagc ggatccggcc ggcgttcacg
2485861 taccggcgca gcctgggtgt gcttaccgct gcgcgcgacg ccggcctggt caccaagagc
2485921 aacctcatcc tcggcctggg cgaaacctcc gacgaggtgc gcaccgccct gggcgatctg
2485981 cgcgacgccg gctgcgacat cgttaccatc acccaatacc tgcggccgtc ggcgcgccac
2486041 catccggtcg agcgctgggt gaagcccgag gagttcgtcc agttcgcgcg attcgccgaa
2486101 gggctgggct tcgccggggt attggcggga cccctggtta ggtcgtcata tcgggcgggc
2486161 cggctctacg aacaggcacg taactcacgg gccttggcat cccgctagcc agcgtttacg
2486221 tattctggac gattatggcg aaaccccgaa atgccgctga aagcaaggcc gccaaagctc
2486281 aggcaaacgc tgctcgtaag gctgccgccc gccagcgccg cgctcagctg tggcaagcgt
2486341 tcaccctgca gcgcaaggag gataagcgcc tgctgccgta catgattggt gctttcttgc
2486401 tgatcgtggg cgcatcggtg ggggtcgggg tgtgggctgg cgggttcacc atgttcacga
2486461 tgatcccgct gggggtgctg ctgggtgcac tggtggcgtt cgtcatcttc ggccggcgag
2486521 cccagcgaac ggtttaccgc aaagccgaag gccaaaccgg cgcagccgcc tgggcgctgg
2486581 acaacctgcg gggcaagtgg cgggtgacgc ccggggtggc cgccaccggc aacctcgacg
2486641 ccgtgcaccg ggtgatcggc cggcccggtg tcatcttcgt cggcgaggga tcagcggccc
2486701 gcgtcaaacc actgctggct caggagaaaa agcgcaccgc gcgactggtc ggggacgtgc
2486761 cgatctacga cattatcgtc ggcaacggcg atggcgaggt tccgctggcc aagttggagc
2486821 gccacctcac ccgccttccg gccaacatca cggtcaagca gatggacacg gtggagtcgc
2486881 gactggcggc gctgggttcg cgtgccggtg cgggcgtcat gcccaaggga ccgctaccca
2486941 ccacggccaa gatgcgcagc gtccagcgca cggtccgccg taagtaacgc ggctcagcgt
2487001 cgcaccaccg ccgtagcagt gagccgatcg tgcagcccac gcccgtccga gtcggtgaac
2487061 agcggcggaa ccaccagccc gatcagcagg ccacgcacca ccagacggcc gatccccacc
2487121 ggccgccggc cacccactgc caccacgacc agacccagca tcaactgccc gggtgtgaat
2487181 ccgaacaagc ggaccgccgc caccccgagc agcagccaaa tcaccaggac aaccgtcgac
2487241 agcatcgggg tcgaccaaac accgaattcc acgcccagca acgccagacc gtaggcgatc
2487301 agccagtcga tcagcagagc cgccagccgg cgccccatcg gagccagcga acccggtccg
2487361 gtgtccggca agcccagcgt cttgccggga tagtcgggcg gcgatttcgc cgtcatcggg
2487421 cagacccgat aaccaggttc ccgttcggca tgccaccggt tacgatcttg ccgaccatgg
2487481 ccccacaata gggccgggga gacccggcgt cagtggtggg cggcacggtc agtaacgtct
2487541 gcgcaacacg gggttgactg acgggcaata tcggctccat agcgtcggcc gcggatacag
2487601 taaaggagca ttctgtgacg gaaaagacgc ccgacgacgt cttcaaactt gccaaggacg
2487661 agaaggtcga atatgtcgac gtccggttct gtgacctgcc tggcatcatg cagcacttca
2487721 cgattccggc ttcggccttt gacaagagcg tgtttgacga cggcttggcc tttgacggct
2487781 cgtcgattcg cgggttccag tcgatccacg aatccgacat gttgcttctt cccgatcccg
2487841 agacggcgcg catcgacccg ttccgcgcgg ccaagacgct gaatatcaac ttctttgtgc
2487901 acgacccgtt caccctggag ccgtactccc gcgacccgcg caacatcgcc cgcaaggccg
2487961 agaactacct gatcagcact ggcatcgccg acaccgcata cttcggcgcc gaggccgagt
2488021 tctacatttt cgattcggtg agcttcgact cgcgcgccaa cggctccttc tacgaggtgg
2488081 acgccatctc ggggtggtgg aacaccggcg cggcgaccga ggccgacggc agtcccaacc
2488141 ggggctacaa ggtccgccac aagggcgggt atttcccagt ggcccccaac gaccaatacg
2488201 tcgacctgcg cgacaagatg ctgaccaacc tgatcaactc cggcttcatc ctggagaagg
2488261 gccaccacga ggtgggcagc ggcggacagg ccgagatcaa ctaccagttc aattcgctgc
2488321 tgcacgccgc cgacgacatg cagttgtaca agtacatcat caagaacacc gcctggcaga
2488381 acggcaaaac ggtcacgttc atgcccaagc cgctgttcgg cgacaacggg tccggcatgc
2488441 actgtcatca gtcgctgtgg aaggacgggg ccccgctgat gtacgacgag acgggttatg
2488501 ccggtctgtc ggacacggcc cgtcattaca tcggcggcct gttacaccac gcgccgtcgc
2488561 tgctggcctt caccaacccg acggtgaact cctacaagcg gctggttccc ggttacgagg
2488621 ccccgatcaa cctggtctat agccagcgca accggtcggc atgcgtgcgc atcccgatca
2488681 ccggcagcaa cccgaaggcc aagcggctgg agttccgaag ccccgactcg tcgggcaacc
2488741 cgtatctggc gttctcggcc atgctgatgg caggcctgga cggtatcaag aacaagatcg
2488801 agccgcaggc gcccgtcgac aaggatctct acgagctgcc gccggaagag gccgcgagta
2488861 tcccgcagac tccgacccag ctgtcagatg tgatcgaccg tctcgaggcc gaccacgaat
2488921 acctcaccga aggaggggtg ttcacaaacg acctgatcga gacgtggatc agtttcaagc
2488981 gcgaaaacga gatcgagccg gtcaacatcc ggccgcatcc ctacgaattc gcgctgtact
2489041 acgacgttta aggactcttc gcagtccggg tgtagaggga gcggcgtgtc gttgccaggg
2489101 cgggcgtcga ggtttttcga tgggtgacgg tggccggcaa cggcgcgccg accaccgctg
2489161 cgaagagccc gtttaagaac gttcaaggac gtttcagccg ggtgccacaa cccgcttggc
2489221 aatcatctcc cgaccgccga gcgggttgtc tttcacatgc gccgaaactc aagccacgtc
2489281 gtcgcccagg cgtgtcgtcg cggccggttc aggttaagtg tcggggattc gtcgtgcggg
2489341 cgggcgtcca cgctgaccaa cggggcagtc aactcccgaa cactttgcgc actaccgcct
2489401 ttgcccgccg cgtcacccgt aggtagttgt ccaggaattc cccaccgtcg tcgtttcgcc
2489461 agccggccgc gaccgcgacc gcattgagct ggcgcccggg tcccggcagc tggtcggtgg
2489521 gcttgccgcg caccaacacc agcgcgttgc gggcccgggt ggcggtcagc caggcctgac
2489581 ggagcagctc cacgtcggct gcgggaacca gatcggcggc cgcgatgaca tccagggatt
2489641 gcagcgtcga ggtgttgtgc agggcgggaa cctggtgcgc atgctgtagc tgcagcaact
2489701 gcacggtcca ttcgatgtcg gccagtccgc cgcggcccag tttggtgtgt gtgttggggt
2489761 cggcaccgcg cggcaaccgc tcggactcga tacgggcctt gatgcggcga atctcgcgca
2489821 ccgagtcagc ggacacaccg tcgggcggat accgcgtttt gtcgaccatc cgtaggaatc
2489881 gctgacccaa ctcggcatcg ccggcaaccg cgtgtgcgcg tagcagggcc tggatctccc
2489941 atggctgtgc ccactgctcg tagtatgcgg cgtaggaccc cagggtgcgg accagcggac
2490001 cgttgcggcc ctcgggtcgc aaattggcgt cgagctccag cggcggatcg acgctgggtg
2490061 tccccagcag cgcccgaacc cgctcggcga tcgatgtcga ccatttcacc gcccgtgcat
2490121 cgtcgacgcc ggtggccggc tcacagacga acatcacgtc ggcatccgac ccgtagccca
2490181 actcggcacc acccagccga cccatgccga tgaccgcgat ggccgccggg gcgcgatcgt
2490241 cgtcgggaag gctggcccgg atcatgacgt ccagcgcggc ctgcagcacc gccacccaca
2490301 ccgacgtcaa cgcccggcac acctcggtga cctcgagcag gccgagcagg tccgccgaac
2490361 cgatgcgggc cagctctcga cgacgcagcg tgcgcgcgcc ggcgatggcc cgctccgggt
2490421 cggggtagcg gctcgccgag gcgatcagcg cccgagccac ggcggcgggc tcggtctcga
2490481 gcagcttcgg gcccgcaggc ccgtcctcgt actgctggat gacccgcggc gcgcgcatca
2490541 acagatccgg cacatacgcc gaggtaccca agacatgcat gagccgcttg gccaccgcgg
2490601 gcttgtcccg cagcgtggcc aggtaccagc tttcggtggc cagcgcctca ctgagccgcc
2490661 ggtaggccag cagtccgccg tcgggatcgg gggcatacga catccagtcc agcagcctgg
2490721 gcagcagcac cgactgcacc cgtccgcgcc ggccgctttg attgaccaac gccgacatgt
2490781 gtttcaacgc ggtctgcggt ccctcgtagc ccagcgcggc cagccggcgc cccgcggcct
2490841 ccaacgtcat gccgtgggcg atctccaacc cggtcgggcc gatcgattcc agcagcggtt
2490901 gatagaagag tttggtgtgt aacttcgaca cccgcacgtt ctgcttcttg agttcctccc
2490961 gcagcacccc ggccgcatcg tttcggccat cgggccggat gtgggccgcg cgcgccagcc
2491021 agcgcactgc ctcctcgtct tcgggatcgg gaagcaggtg ggtgcgcttg agccgctgca
2491081 actgcagtcg gtgctcgagc agcctgagga actcatacga cgcggtcatg ttcgccgcgt
2491141 cctcacgccc gatgtagccg ccttcgccca acgccgccaa tgcgtccacc gtggacgcca
2491201 cccgtaacga ctcgtcgcta cgggcatgaa ccagctgcag tagctgtacg gcgaactcca
2491261 cgtcgcgcaa tccgccgctg ccgagtttga gctcgcggcc gcggacatcg gcgggcacca
2491321 gctgctccac ccgccgccgc atggcctgca cctcgaccac aaagtcttcg cgctcgcagg
2491381 ctcgccacac catcggcatc aaggcggtca ggtaacgctc gccaagttcc gcgtcgccaa
2491441 cgactggccg tgctttcagc aacgcctgaa actcccaggt cttggcccag cgctggtagt
2491501 aggcgatgtg cgactcgagc gtacggacca gctccccgtt gcgcccctcc ggacgcaggg
2491561 cggcgtccac ctcgaaaaag gccgccgagg ccacccgcat catctcgctg gccacgcgcg
2491621 cgttgcgcgg gtcggagcgc tcggcaacga atatgacatc gacgtcgctg acgtagttca
2491681 gttcgcgcgc accgcacttg cccatcgcga tgaccgccag gcgcggtggc gggtgctcgc
2491741 cgcacacgct cgcctcggcc acgcgcagcg ccgccgccag agcggcgtcc gcggcgtccg
2491801 ccaggcgtgc ggccaccacg gtgaatggca gcaccggttc gtcctcgacc gtcgcggcca
2491861 ggtcgagagc ggccagcatt agcacgtagt cgcggtactg ggttcgcaat cggtgcacga
2491921 gcgagcccgg cataccctcc gattcctcga cgcactcgac gaacgaccgc tgcagctggt
2491981 catgggacgg cagtgtgacc ttgccccgca gcaatttcca ggactgcgga tgggcgacca
2492041 ggtgatcgcc caacgccagc gacgagccca gcaccgagaa cagccgcccg cgcagactgc
2492101 gttcgcgcag cagagccgcg ttgagctcgt cccatccggt gtctggattc tccgacagcc
2492161 ggatcaaggc gcgcagcgcg gcatcggcgt ccggagcgcg tgacagcgac cacagcaggt
2492221 cgacgtgcgc ctgatcctcg tgccgatccc accccagctg agccagacgc tcaccagcag
2492281 gggggtcaac taatccgagc cggccaacgc tgggcaactt cggccgctgc gtggcgagtt
2492341 tggtcacgac cacgacggta gcgcaaagcg cgtcggcgtc ggatcaaccg gtagatctgg
2492401 gctacagcga caggtaggtg cgcagctcgt atggcgtgac gtggctgcgg tagttcgccc
2492461 actccgtgcg cttgttgcgc aagaaaaagt caaaaacgtg ctcccccaag gcctccgcga
2492521 cgagttcgga ggcctccatg gcgcgcagcg cactatccaa actggacggc aattctcggt
2492581 accccatcgc tcggcgttcc tcgggtgtga ggtcccatac gttgtcctcg gcctgcgggc
2492641 ccagcacgta acccttctct acaccccgca atcccgcggc cagcagcacg gcgaatgtca
2492701 gatagggatt gcacgccgaa tcagggctgc gtacttcgac ccgccgcgac gaggtcttgt
2492761 gcggcgtgta catcggcacc cgcactaggg cggatcggtt ggcggccccc cacgacgcgg
2492821 ccgtgggcgc ttcgccgccc tgcaccagcc gcttgtaaga gttgacccac tgatttgtga
2492881 ccgcgctgat ctcgcaagcg tgctccagga tcccggcgat gaacgattta cccacttccg
2492941 acagctgcag cggatcatca gcgctgtgga acgcgttgac atcaccctcg aacaggctca
2493001 tgtgggtgtg catcgccgag cccgggtgct ggccgaatgg cttgggcatg aacgacgccc
2493061 gggcgccctc ttccagcgcg acttctttga tgacgtagcg gaaggtcatc acgttgtcag
2493121 ccatcgacag agcgtcggca aaccgcaggt cgatctcctg ctggccgggt gcgccttcgt
2493181 gatggctgaa ctccaccgag atgcccatga attccagggc atcgatcgcg tggcggcgaa
2493241 agttcaaggc ggagtcgtgc accgcttggt cgaaatagcc ggcgttgtcg accgggacgg
2493301 gcaccgaccc gtcctcgggt ccgggcttga gcaggaagaa ctcgatttcg ggatgcacgt
2493361 agcaggagaa gccgagttcg ccggccttcg tcagctgccg ccgcaacacg tgccgcgggt
2493421 ccgcccacga cggcgagccg tccggcatgg tgatgtcgca aaacatccgc gctgagtggt
2493481 ggtggccgga actggtggcc cagggcagca cctggaaggt cgacgggtcc gggtgcgcca
2493541 ccgtatcgga ttccgagacc cgcgcaaagc cctcgatcga ggatccgtcg aagccgatgc
2493601 cttcctcgaa ggcgccctcg agttcggctg gggcgatggc gaccgacttg aggaaaccga
2493661 gcacgtctgt gaaccacagc cggacgaagc ggatgtcgcg ttcttccagg gtacgaagaa
2493721 cgaattcctt ctgtcggtcc atacctcgaa cagtatgcac tgtctgttaa aaccgtgtta
2493781 ccgatgcccg gccagaagcg ttgcggggcg gcccgcaagg ggagtgcgcg gtgagttcag
2493841 ggcgcgcacc gcagactcgt cggcggcaag gtcccgtcga gaaaatagtg catcaccgca
2493901 gagtccacac actggttgcc atcgaacacc gcagtgtgtt gggtgccgtc gaaggtgatc
2493961 agcggtgcgc ccagctggcg ggccaggtct accccggact gatacggagt ggccgggtcg
2494021 tgggtggtgg acaccacgac gaccttgcca gccccggccg gcgccgcggg gtgcggcgtc
2494081 gacgttgccg gcaccggcca cagcgcgcac agatcgcggg gggcggatcc ggtgaactgc
2494141 ccgtagctaa ggaacggggc gacctgacgg atccgttggt cggcggccac ccaggccgct
2494201 ggatcggccg gtgtgggcgc atcgacgcac cggaccgcgt tgaacgcgtc ctggtcgttg
2494261 ctgtagtgcc cgtctgcatc ccggccgtca tagtcgtcgg caagcaccag caagtcgccg
2494321 gcgtcgctgc cgcgctgcag ccccagcaga ccactggtca ggtacttcca gcgctgaggg
2494381 ctgtacagcg cgttgatggt gcccgtcgtc gcgtcggcgt agctcaggcc acgtggatcc
2494441 gacgtcttac ccggcttctg caccagcggg tcaaccaggg cgtggtagcg gttgacccac
2494501 tgggccgagt cggtgcccag agggcaggcc ggcgagcggg cgcagtcggc ggcgtagtca
2494561 ttgaaagcgg tctgaaatcc cgccatttgg ctgatgcttt cctcgattgg gctaacggct
2494621 ggatcgatag cgccgtcgag gaccatcgcc cgcacatgag taccgaaccg ttccaggtaa
2494681 gcggtgccca actcggtgcc gtagctgtat ccgaggtagt tgatctgatc gtcacctaac
2494741 gcttggcgaa ccatgtccat gtcccgtgcg acggacgcgg taccgatatt ggccaagaag
2494801 ctgaagccca tccggtcaac acagtcctgg gccaactgcc ggtagacctg ttcgacgtgg
2494861 gtgacaccgg ccggactgta gtcggccatc ggatcgcgcc ggtacgcgtc gaactcggcg
2494921 tcggtgcgac accgcaacgc aggggtcgag tggccgaccc ctctcgggtc gaagcccacc
2494981 aggtcgaagt ggcggagaat gtcggtgtcg gcgatcgcgg gtgccatagc ggcgaccatg
2495041 tcgaccgccg acgccccggg tcccccagga ttgaccagca gtgctccgaa tcgctgtccc
2495101 gtcgcgggga cgcggatcac cgccaacttc gcttgtgtcc caccgggttg gtcgtagtcg
2495161 acggggacgg acaccgtcgc gcagcgtgca gtgcgaattt cgctggtgtc ggcgatgaac
2495221 tcgcggcagc tgttccaact ctgttgcggc gccacgaccg gcgcacccgg ggtttggccg
2495281 gcgccgggtt cttcagtcgc gccggccaac gggggcgctg ctaggggcag tccgccgagc
2495341 agcaacccga aggacagcag cgccgagctc aacggtctgc ggcgccacat ggccgccatc
2495401 gtctcaccgg cgaatacctg tgacggcgcg aaatgatcac accttcgttt cttcgccccg
2495461 ctagcacttg gcgccgctgg gcggcgtggt gccgccgatt aaatacgccg tcacgtactc
2495521 gtcaatgcag ctgtcgccct ggaataccac cgtgtgctgg gttccgtcga aggtcagcaa
2495581 cgaaccgcga agctggttcg ccaggtcgac cccggccttg tacggcgtcg ccgggtcatg
2495641 ggtggtggat accaccaccg tcggcactag gccgggcgcc gagacggcat ggggctgact
2495701 tgtgggtggc accggccaga acgcgcaggt gcccagcggc gcatcaccgg tgaacttccc
2495761 gtagctcatg aacggtgcga tctcccgggc gcggcggtct tcgtcgatga ccttgtcgcg
2495821 atcggtaacc gggggctgat cgacgcaatt gatcgccacc cgcgcgtcac cggaattgtt
2495881 gtagcggccg tgcgagtccc gacgcatgta catgtcggcc agagccagca gggtgtctcc
2495941 gcgattgtcg accagctccg acagcccgtc ggtcaagtgt tgccacagat tcggtgagta
2496001 cagcgccata atggtgccca cgatggcgtc gctataactc agcccgcgcg gatccttcgt
2496061 gcgcgccggc ctgctgatcc tcgggttgtc cgggtcgacc aacggatcga ccaggctgtg
2496121 gtagacctcg acggctttgg ccgggtcggc gcccagcggg cagcccgcgt tcttggcgca
2496181 gtcggcggca tagttgttga acgcgtcctg gaagcccttg gcctggcgca gctccgcctc
2496241 gatgggatcg gcattggggt cgacggcacc gtcgagaatc attgcccgca cccgctgcgg
2496301 aaattcctcg gcatacgcgg agccgatccg ggtgccgtac gagtagccca ggtaggtcag
2496361 cttgtcgtcg cccaacgccg cgcgaatggc atccaggtcc ttggcgacgt tgaccgtccc
2496421 gacatgggcc agaaagttct tgcccatctt gtccacacag cgaccgacga attgcttggt
2496481 ctcgttctcg atgtgcgcca caccctcccg gctgtagtca acctgcggct cggcccgcag
2496541 ccggtcgttg tcggcatcgg agttgcacca gatcgccggc cgggacgacg ccaccccgcg
2496601 ggggtcgaac ccaaccaggt cgaacctttc gtgcacccgc ttcggcaatg tctggaagac
2496661 gcccaaggcg gcctcgatac cggattcgcc gggtccaccg ggatttatga ccagcgaacc
2496721 gatcttgtct cccgtcgccg gaaagcgaat cagcgccagc gccgccacgt caccatcggg
2496781 gcggtcgtag tcgaccggta cagcgagctt gccgcataac gcgccgccgg ggatctttac
2496841 ttgcgggttt gacgaccggc acggtgtcca ctccaccggc tggcccagct tcggctccgc
2496901 catacgagcg cgtcccccga ccacgcggat gcagcccaca agaaccaacg ccacggcggc
2496961 gagcgcggcc cagatcaaca gcatgcgcgc gatcttgtcg cggcgagaca gcctcatgcc
2497021 cacaatgctg ccagagcaga cccgagatcc tggccagcgg ccaccgtcgg ccgactaacc
2497081 ggccgctgcc agcagtcctg ccatcgccga tggcgaactc gtcggccatc ccccatacgt
2497141 ccggtaacag atccgggcaa gacaccgacc cgtcgaccgg atccggcacg ggcgcgtcgg
2497201 cctcggcggt gcacaactgc gacatcaggt tggcgctggc accccgtcca cgccggcatg
2497261 gtgcaccttg gccatcgccc gagggcgatc cccgatgccg tccacccctt cgacgaaccc
2497321 atctcccacg gcggtcgccg gcagcgacgc gatgtggccg cagatctccg agagttcggc
2497381 ccgcccgccc ggcgacggca acccgatgcc gtgcaagtga cgatcgatgt gaggttcaag
2497441 gttcagcgca ctgctggcaa gctttttccg aaaccgcggc ctcgccttga tctggagtca
2497501 gaacgcgtca cgcagccggt caaaggcgta acccatgctc gagcaaacat gcatgggctg
2497561 agtggacgtt tccagacaca gcaactggcg tccaggccac tgagccgctg catgcgcgat
2497621 ggtatgccga tgggggcccc gggcgcgtct gaggggaaga agtggcagac tgtcagggtc
2497681 cgacgaaccc ggggacccta acgggccacg aggatcgacc cgaccaccat tagggacagt
2497741 gatgtctgag cagactatct atggggccaa tacccccgga ggctccgggc cgcggaccaa
2497801 gatccgcacc caccacctac agagatggaa ggccgacggc cacaagtggg ccatgctgac
2497861 ggcctacgac tattcgacgg cccggatctt cgacgaggcc ggcatcccgg tgctgctggt
2497921 cggtgattcg gcggccaacg tcgtgtacgg ctacgacacc accgtgccga tctccatcga
2497981 cgagctgatc ccgctggtcc gtggcgtggt gcggggtgcc ccgcacgcac tggtcgtcgc
2498041 cgacctgccg ttcggcagct acgaggcggg gcccaccgcc gcgttggccg ccgccacccg
2498101 gttcctcaag gacggcggcg cacatgcggt caagctcgag ggcggtgagc gggtggccga
2498161 gcaaatcgcc tgtctgaccg cggcgggcat cccggtgatg gcacacatcg gcttcacccc
2498221 gcaaagcgtc aacaccttgg gcggcttccg ggtgcagggc cgcggcgacg ccgccgaaca
2498281 aaccatcgcc gacgcgatcg ccgtcgccga agccggagcg tttgccgtcg tgatggagat
2498341 ggtgcccgcc gagttggcca cccagatcac cggcaagctt accattccga cggtcgggat
2498401 cggcgctggg cccaactgcg acggccaggt cctggtatgg caggacatgg ccgggttcag
2498461 cggcgccaag accgcccgct tcgtcaaacg gtatgccgat gtcggtggtg aactacgccg
2498521 tgctgcaatg caatacgccc aagaggtggc cggcggggta ttccccgctg acgaacacag
2498581 tttctgacca agccgaatca gcccgatgcg cgggcattgc ggtggcgccc tggatgccgt
2498641 cgacgccgga ttgccggcgc ggacgcgcca gcgggaccca tcggcgtcgc gttcgccggt
2498701 tgagcccggg gtgagcccag acattcgatg tgcccaacac catccgccac agcccaattg
2498761 atgtggcact ctatgcatgc ctatccccga ccaaccacca ccgcggcgac gcatcatgac
2498821 cggaggcgaa gatgccagta gaggcgccca gaccagcgcg ccatctggag gtcgagcgca
2498881 agttcgacgt gatcgagtcg acggtgtcgc cgtcgttcga gggcatcgcc gcggtggttc
2498941 gcgtcgagca gtcgccgacc cagcagctcg acgcggtgta cttcgacaca ccgtcgcacg
2499001 acctggcgcg caaccagatc accttgcggc gccgcaccgg cggcgccgac gccggctggc
2499061 atctgaagct gccggccgga cccgacaagc gcaccgagat gcgagcaccg ctgtccgcat
2499121 caggcgacgc tgtgccggcc gagttgttgg atgtggtgct ggcgatcgtc cgcgaccagc
2499181 cggttcagcc ggtcgcgcgg atcagcactc accgcgaaag ccagatcctg tacggcgccg
2499241 ggggcgacgc gctggcggaa ttctgcaacg acgacgtcac cgcatggtcg gccggggcat
2499301 tccacgccgc tggtgcagcg gacaacggcc ctgccgaaca gcagtggcgc gaatgggaac
2499361 tggaactggt caccacggat gggaccgccg ataccaagct actggaccgg ctagccaacc
2499421 ggctgctcga tgccggtgcc gcacctgccg gccacggctc caaactggcg cgggtgctcg
2499481 gtgcgacctc tcccggtgag ctgcccaacg gcccgcagcc gccggcggat ccagtacacc
2499541 gcgcggtgtc cgagcaagtc gagcagctgc tgctgtggga tcgggccgtg cgggccgacg
2499601 cctatgacgc cgtgcaccag atgcgagtga cgacccgcaa gatccgcagc ttgctgacgg
2499661 attcccagga gtcgtttggc ctgaaggaaa gtgcgtgggt catcgatgaa ctgcgtgagc
2499721 tggccgatgt cctgggcgta gcccgggacg ccgaggtact cggtgaccgc taccagcgcg
2499781 aactggacgc gctggcgccg gagctggtac gcggccgggt gcgcgagcgc ctggtagacg
2499841 gggcgcggcg gcgataccag accgggctgc ggcgatcact gatcgcattg cggtcgcagc
2499901 ggtacttccg tctgctcgac gctctagacg cgcttgtgtc cgaacgcgcc catgccactt
2499961 ctggggagga atcggcaccg gtaaccatcg atgcggccta ccggcgagtc cgcaaagccg
2500021 caaaagccgc aaagaccgcc ggcgaccagg cgggcgacca ccaccgcgac gaggcattgc
2500081 acctgatccg caagcgcgcg aagcgattac gctacaccgc ggcggctact ggggcggaca
2500141 atgtgtcaca agaagccaag gtcatccaga cgttgctagg cgatcatcaa gacagcgtgg
2500201 tcagccggga acatctgatc cagcaggcca tagccgcgaa caccgccggc gaggacacct
2500261 tcacctacgg tctgctctac caacaggaag ccgacttggc cgagcgctgc cgggagcagc
2500321 ttgaagccgc gctgcgcaaa ctcgacaagg cggtccgcaa agcacgggat tgagcccgcc
2500381 aggggcggac gagttggcct gtaagccgga ttctgttccg cgccgccaca gccaagctaa
2500441 cggcggcacg gcggcgacca tccatctgga cacaccgtta ccgggtgcct cgagcggcct
2500501 acccgcaggc tcgggcgagc aaccctcaag cgcctgcgcg gccgcacttt cggtgcggcc
2500561 ttcttggcct tgcttcgggt ggggtttgcc tagccacccc ggtcacccgg aatgctggtg
2500621 cgctcttacc gcaccgtttc acccttgcca ccacgaggat ggcggtctgt tttctgtggc
2500681 actttcccgc gagtcacctc ggattgccgt tagcaatcac cctgctctgt gaagtccgga
2500741 ctttcctcga ctcgacgctg aacctcgtga atccacacaa gccctacgcg agccgcggcc
2500801 gcccagccaa ctcatccgcg acgaccacgc taccccgctg ggcggtgtcg cggccagtgt
2500861 gaccgctgga cgacacggct agtcggacag ccgatccggc gggcagtcct tatcgtggac
2500921 tggtgacacg gtgggacaaa cgcgtcgact ccggcgactg ggacgccatc gctgccgagg
2500981 tcagcgagta cggtggcgca ctgctacctc ggctgatcac ccccggcgag gccgcccggc
2501041 tgcgcaagct gtacgccgac gacggcctgt ttcgctcgac ggtcgatatg gcatccaagc
2501101 ggtacggcgc cgggcagtat cgatatttcc atgcccccta tcccgagtga tcgagcgtct
2501161 caagcaggcg ctgtatccca aactgctgcc gatagcgcgc aactggtggg ccaaactggg
2501221 ccgggaggcg ccctggccag acagccttga tgactggttg gcgagctgtc atgccgccgg
2501281 ccaaacccga tccacagcgc tgatgttgaa gtacggcacc aacgactgga acgccctaca
2501341 ccaggatctc tacggcgagt tggtgtttcc gctgcaggtg gtgatcaacc tgagcgatcc
2501401 ggaaaccgac tacaccggcg gcgagttcct gcttgtcgaa cagcggcctc gcgcccaatc
2501461 ccggggtacc gcaatgcaac ttccgcaggg acatggttat gtgttcacga cccgtgatcg
2501521 gccggtgcgg actagccgtg gctggtcggc atctccagtg cgccatgggc tttcgactat
2501581 tcgttccggc gaacgctatg ccatggggct gatctttcac gacgcagcct gattgcacgc
2501641 catctataga tagcctgtct gattcaccaa tcgcaccgac gatgccccat cggcgtagaa
2501701 ctcggcgatg ctcagcgatg ccagatcaag atgcaaccga tataggacgc ccgacccggc
2501761 atccaacgcc agccgcaaca acattttgat cggcgtgaca tgtgacacca ccagcaccgt
2501821 cgcgccttcg tagccaacga tgatccgatc acgtccccgc cgaacccgcc gcagcacgtc
2501881 gtcgaagctt tccccacccg ggggcgtgat gctggtgtcc tgcagccagc gacggtgcag
2501941 ctcgggatcg cgttctgcgg cctccgcgaa cgtcagcccc tcccaggcgc cgaagtcggt
2502001 ctcgaccagg tcgtcatcga cgaccacgtc cagggccagg gctctggcgg cggtcaccgc
2502061 ggtgtcgtaa gcccgctgta gcggcgagga gaccaccgca gcgatcccgc cgcgccgcgc
2502121 cagatacccg gccgccgcac caacctggcg ccaccccacc tcgttcaacc ccgggttgcc
2502181 gcgccccgaa tagcggcgtt gctccgacag ctccgtctgc ccgtggcgca acaaaagtag
2502241 tcgggtgggt gtaccgcggg cgccggtcca gccgggagat gtcggtgact cggtcgcaac
2502301 gattttggca ggatccgcat ccgccgcagc cgattgcgcg gcggcgtcca tcgcgtcatt
2502361 ggccaaccgg tctgcatacg tgttccgggc acgcggaacc cactcgtagt tgatcctgcg
2502421 aaactgggac gccaacgcct gagcctggac atagagcttc agcagatccg ggtgcttgac
2502481 cttccaccgc ccggacatct gctccaccac cagcttggag tccatcagca ccgcggcctc
2502541 ggtggcacct agtttcacgg cgtcgtccaa accggctatc aggccgcggt attcggcgac
2502601 gttgttcgtc gcccggccga tcgcctgctt ggactcggcc agcacggtgg agtgatcggc
2502661 ggtccacacc accgcgccgt atccggccgg tccgggattg ccccgcgatc cgccgtcggc
2502721 ttcgatgaca actttcactc ctcaaatcct tcgagccgca acaagatcgc tccgcattcc
2502781 gggcagcgca ccacttcatc ctcggcggcc gccgagatct gggccagctc gccgcggccg
2502841 atctcgatcc ggcaggcacc acatcgatga ccttgcaacc gcccggcccc tggcccgcct
2502901 ccggcccgct gtctttcgta gagccccgca agctcgggat caagtgtcgc cgtcagcatg
2502961 tcgcgttgcg atgaatgttg gtgccgggct tggtcgattt cggcaagtgc ctcgtccaaa
2503021 gcctgctggg cggcggccag gtcggcccgc aacgcttgga gcgcccgcga ctcggcggtc
2503081 tgttgagcct gcagctcctc gcggcgttcc agcacctcca gcagggcatc ttccaaactg
2503141 gcttgacggc gttgcaagct gtcgagctcg tgctgcagat cagccaattg cttggcgtcc
2503201 gttgcacccg aagtgagcaa cgaccggtcc cggtcgccac gcttacgcac cgcatcgatc
2503261 tccgactcaa aacgcgacac ctggccgtcc aagtcctccg ccgcgattcg cagggccgcc
2503321 atcctgtcgt tggcggcgtt gtgctcggcc tgcacctgct ggtaagccgc ccgctgcggc
2503381 agatgggtag cccgatgcgc gatccgggtc agctcagcat ccagcttcgc caattccagt
2503441 agcgaccgtt gctgtgccac tccggctttc atgcctgatc tctcccagtt tcgtgatcga
2503501 ggttccacgg gtcggtgcag atggtgcaca cacgcaccgg cagcgacgcg ccgaaatgag
2503561 accgcaacac ttcggcggcc tggccgcacc acgggaattc gcttgcccaa tgcgcgacgt
2503621 cgatcagggc cacttgcgaa gctcggcaat gctcgtcggc tggatgatgt cgcagatcgg
2503681 ccgtaacgta cgcttgcacg tccgcggcgg ccacggtggc aagcaacgag tccccggcgc
2503741 cgccgcagac cgcgacccgc gacaccagca ggtcgggatc cccggcggcg cgcacaccgg
2503801 tcgcagtcgg cggcaacgcg gcctccagac gggcaacaaa ggtgcgcagc ggttcgggtt
2503861 ttggcagtct gccaatccgg cctaacccgc tgccgaccgg cggtggtacc agcgcgaaga
2503921 tgtcgaatgc cggctcctcg taagggtgcg cggcgcgcat cgccgccaac acctcggcgc
2503981 gcgctcgtgc gggtgcgacg acctcgaccc ggtcctcggc cacccgttcg acggtaccga
2504041 cgctgcctat ggcgggcgac gccccgtcgt gcgccaggaa ctgcccggta cccgcgacac
2504101 tccagctgca gtgcgagtag tcgccgatat ggccggcacc ggcctcaaag accgctgccc
2504161 gcaccgcctc tgagttctcg cgcggcacat agatgaccca cttgtcgaga tcggccgctc
2504221 cgggcaccgg gtcgagaacg gcgtcgacgg tcagaccaac agcgtgtgcc agcgcgtcgg
2504281 acacacccgg cgacgccgag tcggcgttgg tgtgcgcggt aaacaacgag cgaccggtcc
2504341 ggatcaggcg gtgcaccagc acaccctttg gcgtgttggc cgcgaccgta tcgaccccac
2504401 gcagtaacaa cgggtggtgc accaatagca gtccggcctg gggaacctgg tccaccaccg
2504461 ccggcgtcgc gtccaccgca acggtcaccg aatccaccac gtcgtcgggg tcgccgcaca
2504521 ccagacccac cgaatcccac gactgggcaa gccgcggcgg gtaggcctgg tccagcacgt
2504581 cgatgacatc ggccagccgc acactcatcg gcgtcctcca cgctttgccc actcggcgat
2504641 cgccgccacc agcacgggcc actccgggcg caccgccgcc cgcaggtacc gcgcgtccag
2504701 gccgacgaag gtgtcaccgc ggcgcaccgc aattcctttg ctctgcaaat agtttcgtaa
2504761 tccgtcagca tcggcgatgt tgaacagtac gaaaggggcc gcaccatcga ccacctcggc
2504821 acccaccgat ctcagtccgg ccaccatctc cgcgcgcagc gccgtcaacc gcaccgcatc
2504881 ggctgcggca gcggcgaccg cccggggggc gcagcaagca gcgatggccg tcagttgcaa
2504941 tgttcccaac ggccagtgcg ctcgctgcac ggtcaaccga gccagcacgt ctggcgagcc
2505001 gagcgcgtag cccacccgca atccggccag cgaccacgtt ttcgtcaagc tacggagcac
2505061 cagcacatcg ggcagcgagt catcggccaa cgattgcggc tcgccgggaa cccaatcagc
2505121 gaacgcctcg tcgaccacca ggatgcgtcc cggccggcgt aactcgagca gctgctcgcg
2505181 gaggtgcagc accgaggtgg ggttggtcgg attacccacg acgacaaggt cggcgtcgtc
2505241 aggcacgtgc gcggtgtcca gcacgaacgg cggctttagg acaacatggt gcgccgtgat
2505301 tccggcagcg ctcaaggcta tggccggctc ggtgaacgcg ggcacgacga ttgctgcccg
2505361 caccggactt aggttgtgca gcaatgcgaa tccctccgcc gccccgacga gcgggagcac
2505421 ttcgtcacgg gttctgccat gacgttcagc gaccgcgtct tgcgcccggt gcacatcgtc
2505481 ggtgctcgga tagcgggcca gctccggcag cagcgcggcg agctgccgga ccaaccattc
2505541 cgggggccgg tcatggcgga cgttgacggc gaagtccagc acgccgggcg cgacatcctg
2505601 atcaccgtgg tagcgcgccg cggcaagcgg gctagtgtct agactcgcca cagcgtcaaa
2505661 cagtagtggg ccggtgtgcg ggccaagaat ccagagcacc gccgacgcgt tgtctacgcg
2505721 gcgacaaccg cgacatcaca ggcagctaac agggcgtcgg cggtgatgat cgtcaggcca
2505781 agcagctgtg cctgggcgat gagcacacgg tcgaatggat gtcgatggtg atccggaagc
2505841 tctgcggtgc gcagtgtgtg cgtggtcaac tgacagcggc gacgtgccgc agcggcgcat
2505901 tcgatcgggc acgtaagagg ccgatggctc gggcggcggg agcttgccga ggcggtagtt
2505961 gatcgcgatc tcccaggcac tggcggccga caagagaatg ctgttgcgga cgtcctgaac
2506021 aatcgcccgt gtttcgttga cggcatccgc agccaaacgt gggtgtcgat gaggtagcgc
2506081 ttcaccggtg aaagcgttcg agcacgtcgt ctgacaacgg agcgtccaaa tcgtcgggca
2506141 cgcggtacac gccatggtca atgcctaacc gccgagtctc atgaggatgc agcggcacaa
2506201 gctttgctac cggctcgccg cggcgggcaa tctcaacctc tgcccgccgt agacgagccg
2506261 cagcagctcg gacaggcgtg tcttcgcctc gtgaacgccg acccgcttcg caggcgccca
2506321 gactttcgcg tcgaccacct gctcaccaaa cttcgcgatc atcgcctgat accacagcgc
2506381 caacgggtag cggtttgtcc aaccgcttcg tcaacgacaa tgggatcgtg accgacacga
2506441 ccgcgagcgg gaccaattgc ccgcctcctc cacgcgccgc cgcacggcgc gcatcgtcgc
2506501 cgggtgaatc gccgcagctg gtgatcttcg atctggacgg cacgctgacc gactcggcgc
2506561 gcggaatcgt atccagcttc cgacacgcgc tcaaccacat cggtgcccca gtacccgaag
2506621 gcgacctggc cactcacatc gtcggcccgc ccatgcatga gacgctgcgc gccatggggc
2506681 tcggcgaatc cgccgaggag gcgatcgtag cctaccgggc cgactacagc gcccgcggtt
2506741 gggcgatgaa cagcttgttc gacgggatcg ggccgctgct ggccgacctg cgcaccgccg
2506801 gtgtccggct ggccgtcgcc acctccaagg cagagccgac cgcacggcga atcctgcgcc
2506861 acttcggaat tgagcagcac ttcgaggtca tcgcgggcgc gagcaccgat ggctcgcgag
2506921 gcagcaaggt cgacgtgctg gcccacgcgc tcgcgcagct gcggccgcta cccgagcggt
2506981 tggtgatggt cggcgaccgc agccacgacg tcgacggggc ggccgcgcac ggcatcgaca
2507041 cggtggtggt cggctggggc tacgggcgcg ccgactttat cgacaagacc tccaccaccg
2507101 tcgtgacgca tgccgccacg attgacgagc tgagggaggc gctaggtgtc tgatccgctg
2507161 cacgtcacat tcgtttgtac gggcaacatc tgccggtcgc caatggccga gaagatgttc
2507221 gcccaacagc ttcgccaccg tggcctgggt gacgcggtgc gagtgaccag tgcgggcacc
2507281 gggaactggc atgtaggcag ttgcgccgac gagcgggcgg ccggggtgtt gcgagcccac
2507341 ggctacccta ccgaccaccg ggccgcacaa gtcggcaccg aacacctggc ggcagacctg
2507401 ttggtggcct tggaccgcaa ccacgctcgg ctgttgcggc agctcggcgt cgaagccgcc
2507461 cgggtacgga tgctgcggtc attcgaccca cgctcgggaa cccatgcgct cgatgtcgag
2507521 gatccctact atggcgatca ctccgacttc gaggaggtct tcgccgtcat cgaatccgcc
2507581 ctgcccggcc tgcacgactg ggtcgacgaa cgtctcgcgc ggaacggacc gagttgatgc
2507641 cccgcctagc gttcctgctg cggcccggct ggctggcgtt ggccctggtc gtggtcgcgt
2507701 tcacctacct gtgctttacg gtgctcgcgc cgtggcagct gggcaagaat gccaaaacgt
2507761 cacgagagaa ccagcagatc aggtattccc tcgacacccc gccggttccg ctgaaaaccc
2507821 ttctaccaca gcaggattcg tcggcgccgg acgcgcagtg gcgccgggtg acggcaaccg
2507881 gacagtacct tccggacgtg caggtgctgg cccgactgcg cgtggtggag ggggaccagg
2507941 cgtttgaggt gttggcccca ttcgtggtcg acggcggacc aaccgtcctg gtcgaccgtg
2508001 gatacgtgcg gccccaggtg ggctcgcacg taccaccgat cccccgcctg ccggtgcaga
2508061 cggtgaccat caccgcgcgg ctgcgtgact ccgaaccgag cgtggcgggc aaagacccat
2508121 tcgtcagaga cggcttccag caggtgtatt cgatcaatac cggacaggtc gccgcgctga
2508181 ccggagtcca gctggctggg tcctatctgc agttgatcga agaccaaccc ggcgggctcg
2508241 gcgtgctcgg cgttccgcat ctagatcccg ggccgttcct gtcctatggc atccaatgga
2508301 tctcgttcgg cattctggca ccgatcggct tgggctattt cgcctacgcc gagatccggg
2508361 cgcgccgccg ggaaaaagcg gggtcgccac caccggacaa gccaatgacg gtcgagcaga
2508421 aactcgctga ccgctacggc cgccggcggt aaaccaacat cacggccaat accgcagccc
2508481 ccgcctggac cacccgcgac agcaccacgg cgcggcgcag atcggccacc ttgggcgacc
2508541 ggccgtcgcc caaggtgggc cggatctgca actcatggtg gtaccgggtg ggcccaccca
2508601 gccgcacgtc aagcgcccca gcaaacgccg cctcgacgac accggcgttg gggctgggat
2508661 ggcgggcggc gtcgcgccgc caggcccgta ccgcaccgcg gggcgaccca ccgaccaccg
2508721 gcgcgcagat caccaccagc accgccgtcg cccgtgcgcc aacatagttg gcccagtcat
2508781 ccaatcgtgc tgcagcccaa ccgaatcgga gataacgcgg cgagcggtag ccgatcatcg
2508841 agtccagggt gttgatggca cgatatccca gcaccgcagg cacgccgctc gaagccgccc
2508901 acagcagcgg caccacctgg gcgtcggcgg tgttttcggc caccgactcc agcgcggcac
2508961 gcgtcaggcc cgggccgccc agctgggccg ggtcacgccc gcacagcgac ggcagcagcc
2509021 gtcgcgccgc ctcgacatcg tcgcgctcca acaggtccga tatctggcgg ccggtgcgcg
2509081 ccagcgaagt tccgcccagc gctgcccagg tggccgtcgc ggtggccgcc acgggccagg
2509141 acctgccggg tagccgctgc agtgccgcgc cgagcaagcc caccgcgccg accagcaggc
2509201 cgacgtgtac cgcaccggcg acccggccgt cacggtaggt gatctgctcc agcttggcgg
2509261 ccgcccgacc gaacagggcc accggatgac ctcgtttggg gtcgccgaac acgacgtcga
2509321 gcaggcagcc gatcagcacg ccgacggccc tggtctgcca ggtcgatgca aacactccgg
2509381 cagcgtcgca cacgtggtct acgctcagct atttatgacc tcatacggca gctatccacg
2509441 atgaagcggc cagctacccg ggttgccgac ctgttgaacc cggcggcaat gttgttgccg
2509501 gcagcgaatg tcatcatgca gctggcagtg ccgggtgtcg ggtatggcgt gctggaaagc
2509561 ccggtggaca gcggcaacgt ctacaagcat ccgttcaagc gggcccggac caccggcacc
2509621 tacctggcgg tggcgaccat cgggacggaa tccgaccgag cgctgatccg gggtgccgtg
2509681 gacgtcgcgc accggcaggt tcggtcgacg gcctcgagcc cagtgtccta taacgccttc
2509741 gacccgaagt tgcagctgtg ggtggcggcg tgtctgtacc gctacttcgt ggaccagcac
2509801 gagtttctgt acggcccact cgaagatgcc accgccgacg ccgtctacca agacgccaaa
2509861 cggttaggga ccacgctgca ggtgccggag gggatgtggc cgccggaccg ggtcgcgttc
2509921 gacgagtact ggaagcgctc gcttgatggg ctgcagatcg acgcgccggt gcgcgagcat
2509981 cttcgcgggg tggcctcggt agcgtttctc ccgtggccgt tgcgcgcggt ggccgggccg
2510041 ttcaacctgt ttgcgacgac gggattcttg gcaccggagt tccgcgcgat gatgcagctg
2510101 gagtggtcac aggcccagca gcgtcgcttc gagtggttac tttccgtgct acggttagcc
2510161 gaccggctga ttccgcatcg ggcctggatc ttcgtttacc agctttactt gtgggacatg
2510221 cggtttcgcg cccgacacgg ccgccgaatc gtctgataga gcccggccga gtgtgagcct
2510281 gacagcccga caccggcggc gtgtgtcgcg tcgccaggtt cacgctcggc gatctagagc
2510341 cgccgaaaac ctacttctgg gttgcctccc gaatcaacgt gctgatctgc tcgagcagct
2510401 cacgcatatc ggcgcgcatc gcatccaccg cggcatacag gtcggccttg gtcgccggca
2510461 gctggtccga cgtcattggc cgcaccggcg gtgctgtctg tcgcgccgcg ctgtcgcttt
2510521 gaaacccagg tcgctcaccc acgaccacga cactgccata tccggcgccc cgccgacaac
2510581 gaagcacagc tagccggtgg gcgcggacgg gatcgaaccg ccgaccgctg gtgtgtaaaa
2510641 ccagagctct accgctgagc tacgcgccca tgaccgccgc aggctacacg ccttgcggcc
2510701 aagcacccaa aaccttaggc cgtaagcgcc gccagagcgt cggtccacag ccgctgatcg
2510761 cgaacttcac ccggctgctt catctcggcg aaccgaatga tccctgaccg atcgaccaca
2510821 aaggtgcccc ggttagcgat gccggcctgc tcgttgaaga cgccgtaggc ctgactgacc
2510881 gcgccgtgtg gccagaagtc cgacaacagc ggaaacgtga atccgctctg cgtcgcccag
2510941 atcttgtgag tgggtggcgg gcccaccgaa atcgctagcg cggcgctgtc gtcgttctca
2511001 aactcgggca ggtgatcacg caactggtcc agctcgccct ggcagatgcc cgtgaacgcc
2511061 aacggaaaga acaccaacag cacgttcttt gcaccccggt agccgcgcag ggtgacaagc
2511121 tgctgattct ggtcgcgcaa cgtgaagtca ggggcggtgg ctccgacgtt cagcatcagc
2511181 gcttgccagc ccgcgatttc ggctgtacca atctgctggc gctccagttg cccagattga
2511241 ccgacgaggt cggcatcagc ccagctgtgg gcgccgcctc ggcaatctcg gcgggcaata
2511301 catggccggg ctggccggtc ttgggcgtca ccacccaaat cacaccgtcc tcggcgagcg
2511361 ggccgatcgc atccatcagg gtgtccacca aatcgccgtc gccatcacgc caccacaaca
2511421 ggacgacatc gatgacctcg tcggtgtctt catcgagcaa ctctcccccg cacgcttctt
2511481 cgatggccgc gcggatgtcg tcgtcggtgt cttcgtccca gccccattcc tggataagtt
2511541 ggtctcgttg gatgcccaat ttgcgggcgt agttcgaggc gtgatccgcc gcgaccaccg
2511601 tggaacctcc ttcagtctcc gcgggccatg tgcacaccgt cgcgatgggc attatcgtcg
2511661 cacagccaga accggtccac ccgcccgcct cagaaggcgg ccacgcacat tgtcaatgcc
2511721 tttgtcttgg tgtcgttgag ccgatcaacc cgccggttga attccgctgt cgacgcgtgc
2511781 gcaccgatgg catttgccac cgcgcgggcc gcgtcgacat atgcgttgag cgcatccccc
2511841 agttgcgcgg acagcgcggc gctcagactg cctgagaccg tcgaggcact gttgttgagc
2511901 gcgtcgatgg ccggaccttc ggtcggcccg gtgttgcggc cctgattgaa cgcggccacg
2511961 taggcgttca ccttgtcgat ggcgtccttg ctggtggccg ccagcgcgtc acacgaggtg
2512021 cgaatcgcct tggtcgtcag cgattgttgg cgctgcgact cccggatgct cgacgtcgcc
2512081 gccgaagccg acaccgacgc ggacaccgac gagcggtagg ccggtgcgac gttggtgtcg
2512141 ggcatggccg taccgtcggt gacagtggta catccgacga tccccatcag cagcagcgcg
2512201 atgcagccga gcgccagggc gcctcgcctg gggagctccc ccccgtgcct gcgaggcacg
2512261 gcgcgccatc cgatgagcac ggcatgtgag gttacctggt cgcagcgcga ccgcgctggc
2512321 cgtggtgtgt cgcgcatccg cagaaccgag cggagtgcgg ctatccgccg ccgacgccgg
2512381 tgcggcacga tagggggacg accatctaaa cagcacgcaa gcggaagccc gccacctaca
2512441 ggagtagtgc gttgaccacc gatttcgccc gccacgatct ggcccaaaac tcaaacagcg
2512501 caagcgaacc cgaccgagtt cgggtgatcc gcgagggtgt ggcgtcgtat ttgcccgaca
2512561 ttgatcccga ggagacctcg gagtggctgg agtcctttga cacgctgctg caacgctgcg
2512621 gcccgtcgcg ggcccgctac ctgatgttgc ggctgctaga gcgggccggc gagcagcggg
2512681 tggccatccc ggcattgacg tctaccgact atgtcaacac catcccgacc gagctggagc
2512741 cgtggttccc cggcgacgaa gacgtcgaac gtcgttatcg agcgtggatc agatggaatg
2512801 cggccatcat ggtgcaccgt gcgcaacgac cgggtgtggg cgtgggtggc catatctcga
2512861 cctacgcgtc gtccgcggcg ctctatgagg tcggtttcaa ccacttcttc cgcggcaagt
2512921 cgcacccggg cggcggcgat caggtgttca tccagggcca cgcttccccg ggaatctacg
2512981 cgcgcgcctt cctcgaaggg cggttgaccg ccgagcaact cgacggattc cgccaggaac
2513041 acagccatgt cggcggcggg ttgccgtcct atccgcaccc gcggctcatg cccgacttct
2513101 gggaattccc caccgtgtcg atgggtttgg gcccgctcaa cgccatctac caggcacggt
2513161 tcaaccacta tctgcatgac cgcggtatca aagacacctc cgatcaacac gtgtggtgtt
2513221 ttttgggcga cggcgagatg gacgaacccg agagccgtgg gctggcccac gtcggcgcgc
2513281 tggaaggctt ggacaacttg accttcgtga tcaactgcaa tctgcagcga ctcgacggcc
2513341 cggtgcgcgg caacggcaag atcatccagg agctggagtc gttcttccgc ggtgccggct
2513401 ggaacgtcat caaggtggtg tggggccgcg aatgggatgc cctgctgcac gccgaccgcg
2513461 acggtgcgct ggtgaattta atgaatacaa cacccgatgg cgattaccag acctataagg
2513521 ccaacgacgg cggctacgtg cgtgaccact tcttcggccg cgacccacgc accaaggcgc
2513581 tggtggagaa catgagcgac caggatatct ggaacctcaa acggggcggc cacgattacc
2513641 gcaaggttta cgccgcctac cgcgccgccg tcgaccacaa gggacagccg acggtgatcc
2513701 tggccaagac catcaaaggc tacgcgctgg gcaagcattt cgaaggacgc aatgccaccc
2513761 accagatgaa aaaactgacc ctggaagacc ttaaggagtt tcgtgacacg cagcggattc
2513821 cggtcagcga cgcccagctt gaagagaatc cgtacctgcc gccctactac caccccggcc
2513881 tcaacgcccc ggagattcgt tacatgctcg accggcgccg ggccctcggg ggctttgttc
2513941 ccgagcgcag gaccaagtcc aaagcgctga ccctgccggg tcgcgacatc tacgcgccgc
2514001 tgaaaaaggg ctctgggcac caggaggtgg ccaccaccat ggcgacggtg cgcacgttca
2514061 aagaagtgtt gcgcgacaag cagatcgggc cgcggatagt cccgatcatt cccgacgagg
2514121 cccgcacctt cgggatggac tcctggttcc cgtcgctaaa gatctataac cgcaatggcc
2514181 agctgtatac cgcggttgac gccgacctga tgctggccta caaggagagc gaagtcgggc
2514241 agatcctgca cgagggcatc aacgaagccg ggtcggtggg ctcgttcatc gcggccggca
2514301 cctcgtatgc gacgcacaac gaaccgatga tccccattta catcttctac tcgatgttcg
2514361 gcttccagcg caccggcgat agcttctggg ccgcggccga ccagatggct cgagggttcg
2514421 tgctcggggc caccgccggg cgcaccaccc tgaccggtga gggcctgcaa cacgccgacg
2514481 gtcactcgtt gctgctggcc gccaccaacc cggcggtggt tgcctacgac ccggccttcg
2514541 cctacgaaat cgcctacatc gtggaaagcg gactggccag gatgtgcggg gagaacccgg
2514601 agaacatctt cttctacatc accgtctaca acgagccgta cgtgcagccg ccggagccgg
2514661 agaacttcga tcccgagggc gtgctgcggg gtatctaccg ctatcacgcg gccaccgagc
2514721 aacgcaccaa caaggcgcag atcctggcct ccggggtagc gatgcccgcg gcgctgcggg
2514781 cagcacagat gctggccgcc gagtgggatg tcgccgccga cgtgtggtcg gtgaccagtt
2514841 ggggcgagct aaaccgcgac ggggtggcca tcgagaccga gaagctccgc caccccgatc
2514901 ggccggcggg cgtgccctac gtgacgagag cgctggagaa tgctcggggc ccggtgatcg
2514961 cggtgtcgga ctggatgcgc gcggtccccg agcagatccg accgtgggtg ccgggcacat
2515021 acctcacgtt gggcaccgac gggttcggct tttccgacac tcggcccgcc gctcgccgct
2515081 acttcaacac cgacgccgaa tcccaggtgg tcgcggtttt ggaggcgttg gcgggcgacg
2515141 gcgagatcga cccatcggtg ccggtcgcgg ccgcccgcca gtaccggatc gacgacgtgg
2515201 cggctgcgcc cgagcagacc acggatcccg gtcccggggc ctaacgccgg cgagccgacc
2515261 gcctttggcc gaatcttcca gaaatctggc gtagctttta ggagtgaacg acaatcagtt
2515321 ggctccagtt gcccgcccga ggtcgccgct cgaactgctg gacactgtgc ccgattcgct
2515381 gctgcggcgg ttgaagcagt actcgggccg gctggccacc gaggcagttt cggccatgca
2515441 agaacggttg ccgttcttcg ccgacctaga agcgtcccag cgcgccagcg tggcgctggt
2515501 ggtgcagacg gccgtggtca acttcgtcga atggatgcac gacccgcaca gtgacgtcgg
2515561 ctataccgcg caggcattcg agctggtgcc ccaggatctg acgcgacgga tcgcgctgcg
2515621 ccagaccgtg gacatggtgc gggtcaccat ggagttcttc gaagaagtcg tgcccctgct
2515681 cgcccgttcc gaagagcagt tgaccgccct cacggtgggc attttgaaat acagccgcga
2515741 cctggcattc accgccgcca cggcctacgc cgatgcggcc gaggcacgag gcacctggga
2515801 cagccggatg gaggccagcg tggtggacgc ggtggtacgc ggcgacaccg gtcccgagct
2515861 gctgtcccgg gcggccgcgc tgaattggga caccaccgcg ccggcgaccg tactggtggg
2515921 aactccggcg cccggtccaa atggctccaa cagcgacggc gacagcgagc gggccagcca
2515981 ggatgtccgc gacaccgcgg ctcgccacgg ccgcgctgcg ctgaccgacg tgcacggcac
2516041 ctggctggtg gcgatcgtct ccggccagct gtcgccaacc gagaagttcc tcaaagacct
2516101 gctggcagca ttcgccgacg ccccggtggt catcggcccc acggcgccca tgctgaccgc
2516161 ggcgcaccgc agcgctagcg aggcgatctc cgggatgaac gccgtcgccg gctggcgcgg
2516221 agcgccgcgg cccgtgctgg ctagggaact tttgcccgaa cgcgccctga tgggcgacgc
2516281 ctcggcgatc gtggccctgc ataccgacgt gatgcggccc ctagccgatg ccggaccgac
2516341 gctcatcgag acgctagacg catatctgga ttgtggcggc gcgattgaag cttgtgccag
2516401 aaagttgttc gttcatccaa acacagtgcg gtaccggctc aagcggatca ccgacttcac
2516461 cgggcgcgat cccacccagc cacgcgatgc ctatgtcctt cgggtggcgg ccaccgtggg
2516521 tcaactcaac tatccgacgc cgcactgaag catcgacagc aatgccgtgt catagattcc
2516581 ctcgccggtc agagggggtc cagcaggggc cccggaaaga taccaggggc gccgtcggac
2516641 ggaaagtgat ccagacaaca ggtcgcggga cgatctcaaa aacatagctt acaggcccgt
2516701 tttgttggtt atatacaaaa acctaagacg aggttcataa tctgttacac cgcgcaaaac
2516761 cgtcttcaca gtgttctctt agacacgtga ttgcgttgct cgcacccgga cagggttcgc
2516821 aaaccgaggg aatgttgtcg ccgtggcttc agctgcccgg cgcagcggac cagatcgcgg
2516881 cgtggtcgaa agccgctgat ctagatcttg cccggctggg caccaccgcc tcgaccgagg
2516941 agatcaccga caccgcggtc gcccagccat tgatcgtcgc cgcgactctg ctggcccacc
2517001 aggaactggc gcgccgatgc gtgctcgccg gcaaggacgt catcgtggcc ggccactccg
2517061 tcggcgaaat cgcggcctac gcaatcgccg gtgtgatagc cgccgacgac gccgtcgcgc
2517121 tggccgccac ccgcggcgcc gagatggcca aggcctgcgc caccgagccg accggcatgt
2517181 ctgcggtgct cggcggcgac gagaccgagg tgctgagtcg cctcgagcag ctcgacttgg
2517241 tcccggcaaa ccgcaacgcc gccggccaga tcgtcgctgc cggccggctg accgcgttgg
2517301 agaagctcgc cgaagacccg ccggccaagg cgcgggtgcg tgcactgggt gtcgccggag
2517361 cgttccacac cgagttcatg gcgcccgcac ttgacggctt tgcggcggcc gcggccaaca
2517421 tcgcaaccgc cgaccccacc gccacgctgc tgtccaaccg cgacgggaag ccggtgacat
2517481 ccgcggccgc ggcgatggac accctggtct cccagctcac ccaaccggtg cgatgggacc
2517541 tgtgcaccgc gacgctgcgc gaacacacag tcacggcgat cgtggagttc ccccccgcgg
2517601 gcacgcttag cggtatcgcc aaacgcgaac ttcggggggt tccggcacgc gccgtcaagt
2517661 cacccgcaga cctggacgag ctggcaaacc tataaccgcg gactcggcca gaacaaccac
2517721 atacccgtca gttcgatttg tacacaacat attacgaagg gaagcatgct gtgcctgtca
2517781 ctcaggaaga aatcattgcc ggtatcgccg agatcatcga agaggtaacc ggtatcgagc
2517841 cgtccgagat caccccggag aagtcgttcg tcgacgacct ggacatcgac tcgctgtcga
2517901 tggtcgagat cgccgtgcag accgaggaca agtacggcgt caagatcccc gacgaggacc
2517961 tcgccggtct gcgtaccgtc ggtgacgttg tcgcctacat ccagaagctc gaggaagaaa
2518021 acccggaggc ggctcaggcg ttgcgcgcga agattgagtc ggagaacccc gatgccgttg
2518081 ccaacgttca ggcgaggctt gaggccgagt ccaagtgagt cagccttcca ccgctaatgg
2518141 cggtttcccc agcgttgtgg tgaccgccgt cacagcgacg acgtcgatct cgccggacat
2518201 cgagagcacg tggaagggtc tgttggccgg cgagagcggc atccacgcac tcgaagacga
2518261 gttcgtcacc aagtgggatc tagcggtcaa gatcggcggt cacctcaagg atccggtcga
2518321 cagccacatg ggccgactcg acatgcgacg catgtcgtac gtccagcgga tgggcaagtt
2518381 gctgggcgga cagctatggg agtccgccgg cagcccggag gtcgatccag accggttcgc
2518441 cgttgttgtc ggcaccggtc taggtggagc cgagaggatt gtcgagagct acgacctgat
2518501 gaatgcgggc ggcccccgga aggtgtcccc gctggccgtt cagatgatca tgcccaacgg
2518561 tgccgcggcg gtgatcggtc tgcagcttgg ggcccgcgcc ggggtgatga ccccggtgtc
2518621 ggcctgttcg tcgggctcgg aagcgatcgc ccacgcgtgg cgtcagatcg tgatgggcga
2518681 cgccgacgtc gccgtctgcg gcggtgtcga aggacccatc gaggcgctgc ccatcgcggc
2518741 gttctccatg atgcgggcca tgtcgacccg caacgacgag cctgagcggg cctcccggcc
2518801 gttcgacaag gaccgcgacg gctttgtgtt cggcgaggcc ggtgcgctga tgctcatcga
2518861 gacggaggag cacgccaaag cccgtggcgc caagccgttg gcccgattgc tgggtgccgg
2518921 tatcacctcg gacgcctttc atatggtggc gcccgcggcc gatggtgttc gtgccggtag
2518981 ggcgatgact cgctcgctgg agctggccgg gttgtcgccg gcggacatcg accacgtcaa
2519041 cgcgcacggc acggcgacgc ctatcggcga cgccgcggag gccaacgcca tccgcgtcgc
2519101 cggttgtgat caggccgcgg tgtacgcgcc gaagtctgcg ctgggccact cgatcggcgc
2519161 ggtcggtgcg ctcgagtcgg tgctcacggt gctgacgctg cgcgacggcg tcatcccgcc
2519221 gaccctgaac tacgagacac ccgatcccga gatcgacctt gacgtcgtcg ccggcgaacc
2519281 gcgctatggc gattaccgct acgcagtcaa caactcgttc gggttcggcg gccacaatgt
2519341 ggcgcttgcc ttcgggcgtt actgaagcac gacatcgcgg gtcgcgaggc ccgaggtggg
2519401 ggtccccccg cttgcggggg cgagtcggac cgatatggaa ggaacgttcg caagaccaat
2519461 gacggagctg gttaccggga aagcctttcc ctacgtagtc gtcaccggca tcgccatgac
2519521 gaccgcgctc gcgaccgacg cggagactac gtggaagttg ttgctggacc gccaaagcgg
2519581 gatccgtacg ctcgatgacc cattcgtcga ggagttcgac ctgccagttc gcatcggcgg
2519641 acatctgctt gaggaattcg accaccagct gacgcggatc gaactgcgcc ggatgggata
2519701 cctgcagcgg atgtccaccg tgctgagccg gcgcctgtgg gaaaatgccg gctcacccga
2519761 ggtggacacc aatcgattga tggtgtccat cggcaccggc ctgggttcgg ccgaggaact
2519821 ggtcttcagt tacgacgata tgcgcgctcg cggaatgaag gcggtctcgc cgctgaccgt
2519881 gcagaagtac atgcccaacg gggccgccgc ggcggtcggg ttggaacggc acgccaaggc
2519941 cggggtgatg acgccggtat cggcgtgcgc atccggcgcc gaggccatcg cccgtgcgtg
2520001 gcagcagatt gtgctgggag aggccgatgc cgccatctgc ggcggcgtgg agaccaggat
2520061 cgaagcggtg cccatcgccg ggttcgctca gatgcgcatc gtgatgtcca ccaacaacga
2520121 cgaccccgcc ggtgcatgcc gcccattcga cagggaccgc gacggctttg tgttcggcga
2520181 gggcggcgcc cttctgttga tcgagaccga ggagcacgcc aaggcacgtg gcgccaacat
2520241 cctggcccgg atcatgggcg ccagcatcac ctccgatggc ttccacatgg tggccccgga
2520301 ccccaacggg gaacgcgccg ggcatgcgat tacgcgggcg attcagctgg cgggcctcgc
2520361 ccccggcgac atcgaccacg tcaatgcgca cgccaccggc acccaggtcg gcgacctggc
2520421 cgaaggcagg gccatcaaca acgccttggg cggcaaccga ccggcggtgt acgcccccaa
2520481 gtctgccctc ggccactcgg tgggcgcggt cggcgcggtc gaatcgatct tgacggtgct
2520541 cgcgttgcgc gatcaggtga tcccgccgac actgaatctg gtaaacctcg atcccgagat
2520601 cgatttggac gtggtggcgg gtgaaccgcg accgggcaat taccggtatg cgatcaataa
2520661 ctcgttcgga ttcggcggcc acaacgtggc aatcgccttc ggacggtact aaaccccagc
2520721 gttacgcgac aggagacctg cgatgacaat catggccccc gaggcggttg gcgagtcgct
2520781 cgacccccgc gatccgctgt tgcggctgag caacttcttc gacgacggca gcgtggaatt
2520841 gctgcacgag cgtgaccgct ccggagtgct ggccgcggcg ggcaccgtca acggtgtgcg
2520901 caccatcgcg ttctgcaccg acggcaccgt gatgggcggc gccatgggcg tcgaggggtg
2520961 cacgcacatc gtcaacgcct acgacactgc catcgaagac cagagtccca tcgtgggcat
2521021 ctggcattcg ggtggtgccc ggctggctga aggtgtgcgg gcgctgcacg cggtaggcca
2521081 ggtgttcgaa gccatgatcc gcgcgtccgg ctacatcccg cagatctcgg tggtcgtcgg
2521141 tttcgccgcc ggcggcgccg cctacggacc ggcgttgacc gacgtcgtcg tcatggcgcc
2521201 ggaaagccgg gtgttcgtca ccgggcccga cgtggtgcgc agcgtcaccg gcgaggacgt
2521261 cgacatggcc tcgctcggtg ggccggagac ccaccacaag aagtccgggg tgtgccacat
2521321 cgtcgccgac gacgaactcg atgcctacga ccgtgggcgc cggttggtcg gattgttctg
2521381 ccagcagggg catttcgatc gcagcaaggc cgaggccggt gacaccgaca tccacgcgct
2521441 gctgccggaa tcctcgcgac gtgcctacga cgtgcgtccg atcgtgacgg cgatcctcga
2521501 tgcggacaca ccgttcgacg agttccaggc caattgggcg ccgtcgatgg tggtcgggct
2521561 gggtcggctg tcgggtcgca cggtgggtgt actggccaac aacccgctac gcctgggcgg
2521621 ctgcctgaac tccgaaagcg cagagaaggc agcgcgtttc gtgcggctgt gcgacgcgtt
2521681 cgggattccg ctggtggtgg tggtcgatgt gccgggctat ctgcccggtg tcgaccagga
2521741 gtggggtggc gtggtgcgcc gtggcgccaa gttgctgcac gcgttcggcg agtgcaccgt
2521801 tccgcgggtc acgctggtca cccgaaagac ctacggcggg gcatacattg cgatgaactc
2521861 ccggtcgttg aacgcgacca aggtgttcgc ctggccggac gccgaggtcg cggtgatggg
2521921 cgctaaggcg gccgtcggca tcctgcacaa gaagaagttg gccgccgctc cggagcacga
2521981 acgcgaagcg ctgcacgacc agttggccgc cgagcatgag cgcatcgccg gcggggtcga
2522041 cagtgcgctg gacatcggtg tggtcgacga gaagatcgac ccggcgcata ctcgcagcaa
2522101 gctcaccgag gcgctggcgc aggctccggc acggcgcggc cgccacaaga acatcccgct
2522161 gtagttctga ccgcgagcag acgcagaatc gcacgcgcga ggtccgcgcc gtgcgattct
2522221 gcgtctgctc gccagttatc cccagcggtg gctggtcaac gcgaggcgct cctcgcatgc
2522281 tcggacggtg cctaccgacg cgctaacaat tctcgagaag gccggcgggt tcgccaccac
2522341 cgcgcaattg ctcacggtca tgacccgcca acagctcgac gtccaagtga aaaacggcgg
2522401 cctcgttcgc gtttggtacg gggtctacgc ggcacaagag ccggacctgt tgggccgctt
2522461 ggcggctctc gatgtgttca tgggggggca cgccgtcgcg tgtctgggca ccgccgccgc
2522521 gttgtatgga ttcgacacgg aaaacaccgt cgctatccat atgctcgatc ccggagtaag
2522581 gatgcggccc acggtcggtc tgatggtcca ccaacgcgtc ggtgcccggc tccaacgggt
2522641 gtcaggtcgt ctcgcgaccg cgcccgcatg gactgccgtg gaggtcgcac gacagttgcg
2522701 ccgcccgcgg gcgctggcca ccctcgacgc cgcactacgg tcaatgcgct gcgctcgcag
2522761 tgaaattgaa aacgccgttg ctgagcagcg aggccgccga ggcatcgtcg cggcgcgcga
2522821 actcttaccc ttcgccgacg gacgcgcgga atcggccatg gagagcgagg ctcggctcgt
2522881 catgatcgac cacgggctgc cgttgcccga acttcaatac ccgatacacg gccacggtgg
2522941 tgaaatgtgg cgagtcgact tcgcctggcc cgacatgcgt ctcgcggccg aatacgaaag
2523001 catcgagtgg cacgcgggac cggcggagat gctgcgcgac aagacacgct gggccaagct
2523061 ccaagagctc gggtggacga ttgtcccgat tgtcgtcgac gatgtcagac gcgaacccgg
2523121 ccgcctggcg gcccgcatcg cccgccacct cgaccgcgcg cgtatggccg gctgaccgct
2523181 ggtgagcaga cgcagagtcg cactgcggcc ggcgcagtgc gactctgcgt ctgctcgcgc
2523241 tcaacggctg aggaactcct tagccacggc gactacgcgc tcgcgatccc gtggcaccag
2523301 accgatccgg gtccggcggt cgaggatatc gtccacatcc agcgccccct catgggtcac
2523361 cgcgtattcg aactccgccc gggtcacgtc gatgccgtcg gcgaccggct cggtgggccg
2523421 ctcacatgtg gcggcggcag cgacgttggc cgcctcggcc ccgtaccgcg ccaccagcga
2523481 ctcgggcaat ccggcgcccg atccgggggc cggcccaggg ttcgccggtg cgccgatcag
2523541 cggcaggttg cgagtgcggc acttcgcggc tcgcaggtgt cgcagcgtga tggcgcgatt
2523601 cagcacatcc tctgccatgt agcggtattc cgtcagcttg ccgccgacca cactgatcac
2523661 gcccgacggc gattcaaaaa cagcgtggtc acgcgaaacg tcggcggtgc ggccctggac
2523721 accagcaccg ccggtgtcga ttagcggccg caatcccgca taggcaccga tgacatcctt
2523781 ggtgccgacc gccgtcccca atgcggtgtt caccgtatcc agcaggaacg tgatctcttc
2523841 cgaagacggt tgtggcacat cgggaatcgg gccgggtgcg tcttcgtcgg tcagcccgag
2523901 atagatccgg cccagctgct cgggcatggc gaacacgaag cggttcagct caccggggat
2523961 cggaatggtc agcgcggcag tcggattggc aaacgacttc gcgtcgaaga ccagatgtgt
2524021 gccgcggctg gggcgtagcc tcagggacgg gtcgatctca cccgcccaca cgcccgccgc
2524081 gttgatgacg gcacgcgccg acagcgcgaa cgactgccgg gtgcgccggt cggtcaactc
2524141 caccgaagtg ccggtgacat tcgacgcgcc cacgtaagtg aggatgcggg cgccgtgctg
2524201 ggccgcggtg cgcgcgacgg ccatgaccag ccgggcgtcg tcgatcaatt gcccgtcgta
2524261 cgcgagcaga ccaccgtcga ggccgtcccg ccgaacggtg ggagcaatct ccaccacccg
2524321 tgacgccggg attcggcgcg atcggggcaa cgtcgccgcc ggcgtacccg ctagcacccg
2524381 caaagcgtcg ccggccagga aaccggcacg caccaacgcc cgcttggtgt gacccatcga
2524441 cggcaacaac gggaccagtt gcggcatggc atgcacgaga tgaggagcgt tgcgtgtcat
2524501 caggattccg cgttcgacgg cgctgcgccg ggcgatgccc acgttgccgc tggccagata
2524561 gcgcagaccg ccgtgcacca acttcgagct ccagcggctg gtgccgaacg ccagatcatg
2524621 cttttccacc aaggccaccg tcagaccgcg ggtggcagca tctaaggcaa tgccaacacc
2524681 ggtaatgccg ccgcctatca cgatgacgtc gagtgcgcca ccgtcggcca gtgcggtcag
2524741 gtcggcggag cgacgcgccg cgttgagtgc agccgagtgg ggcatcagca caaatatccg
2524801 ttcagtgcgt gggtaagttc ggtggccagc gcggcggaat cgaggatcga atcgacgatg
2524861 tccgcggact ggatggtcga ctgggcgatc agcaacacca tggtcgccag tcgacgagcg
2524921 tcgccggagc gcacactgcc cgaccgctgc gccactgtca gccgggcggc caacccctcg
2524981 atcaggacct gctggctggt gccgaggcgc tcggtgatgt acaccctggc cagctccgag
2525041 tgcatgaccg acatgatcag atcgtcaccc cgcaaccggt cggccaccgc gacaatctgc
2525101 tttaccaacg cttcccggtc gtccccgtcg aggggcacct cccgcagcac gtcggcgata
2525161 tggctggtca gcatggacgc catgatcgac cgggtgtccg gccagcgacg gtatacggtc
2525221 gggcggctca cgcccgcgcg ccgggcgatc tcggcaagtg tcacccggtc cacgccgtaa
2525281 tcgacgacgc agctcgccgc tgcccgcagg atacgaccac cggtatccgc gcggtcatta
2525341 ctcattgaca gcatgtgtaa tactgtaacg cgtgactcac cgcgaggaac tccttccacc
2525401 gatgaaatgg gacgcgtggg gagatcccgc cgcggccaag ccactttctg atggcgtccg
2525461 gtcgttgctg aagcaggttg tgggcctagc ggactcggag cagcccgaac tcgaccccgc
2525521 gcaggtgcag ctgcgcccgt ccgccctgtc gggggcagac cacgatgcgc tggcgcgcat
2525581 cgtcggcacc gagtatttcc gcaccgccga tcgcgaccgg ctgctgcacg ccggcggcaa
2525641 gtccacccca gacctgctgc ggcgcaaaga caccggtgtc caggatgcgc ccgacgcggt
2525701 gttgctgccc ggcggcccca acgggggagg acgccgtcgc cgacatcttg cactactgct
2525761 ccgaccacgg cattgccgtg gtcccgtttg gtggcggcac cagcgtcgtt ggtgggcttg
2525821 accccgttcg caacgacttt cgcgcggtga tctccctgga tatgcggcgc ttcgaccggc
2525881 tgcaccggat cgatgaggtg tccggcgagg ccgaactgga ggccggtgtc accgggccgg
2525941 aagccgaacg tctgctcggc gaacatggct tctcgctcgg gcacttcccg cagagcttcg
2526001 agttcgccac catcgggggg ttcgcggcca cccgctcgtc aggccaggac tcggctggct
2526061 atggccggtt caacgacatg attcttgggc tgcgcatgat cactccggtg ggggtgctgg
2526121 atctgggtcg agtgccggcg tcggcggccg gcccggacct gcgccagctg gcgatcggct
2526181 ccgaaggcgt cttcggcgtc atcacccggg tgcggctgcg ggtgcaccgg attccggaat
2526241 cgacgcgtta cgaggcgtgg tcgtttcccg atttcgcgac cggggttgcg gcgctgcgca
2526301 ccatcaccca aaccggcacc ggccccaccg tcgttcggct ctctgacgag gccgaaaccg
2526361 gcgtcaacct cgccaccacc gaggcgatcg gggaaaccca aatcaccggc ggctgtttgg
2526421 ggatcaccgt gttcgagggc acccaggaac acaccgagag caggcacgcc gagacgcgcg
2526481 cgttgctggc ggcccgaggc ggcacctcgt tgggcgaagg accggcgcgg gcctgggaac
2526541 gcggcaggtt cgccgcgccg tatctgcgtg actccctgtt ggccgcggga gcgctctgcg
2526601 agaccctcga gaccgccacg gtgtggtcca acacccccgt gctgaaggcc gccgtgaccg
2526661 aagcgctcac cacctcgctg gccgcatcgg gtacaccggc gctggtgatg tgccacgtgt
2526721 cgcacgtgta tcccaccggc gcgtcgttgt acttcaccgt tgtcgccggg cagcgaggcg
2526781 atccgatcga gcagtggctg gccgccaaga aggcggcgtc ggatgcgatc atggccaccg
2526841 gaggaacgat cacgcaccac catgcggttg gttccgacca ccgcccctgg atgcgcgcgg
2526901 aggtgggtga tctgggcgtg acattgttgc gcacgatcaa ggcgacgctg gatccggccg
2526961 gaattctcaa ccctggcaag ctgattccat gagcgccggg cagctgcgcc ggcatgagat
2527021 cggcaaggtc accgcgctga ccaatcccct gtcaggccat ggcgccgccg taaaggctgc
2527081 acacggcgcg atcgcccggc tgaagcatcg gggggtggac gtcgtcgaga tcgtcggcgg
2527141 ggacgcccac gacgcacgcc atctgctcgc cgcggcagtc gcaaaaggca ctgacgcggt
2527201 gatggtgacc ggcggtgacg gagtcgtctc caacgcgcta caggtcttgg cgggcaccga
2527261 cattccgtta ggaatcattc cggccggcac tggtaacgac cacgcacgcg aattcgggct
2527321 tcccacaaag aatcccaagg cagccgcaga tatcgttgtt gacggctgga cggaaaccat
2527381 tgacctgggc cggattcaag acgacaacgg tatcgaaaag tggttcggta ccgtggcggc
2527441 taccggattc gactccctgg tcaacgatcg cgccaaccga atgcgctggc cacacgggcg
2527501 gatgcgctat tacatcgcga tgctcgccga actgtcgcgg ctgcggccgt tgccgttccg
2527561 gctggtgctc gacggcaccg aagagatcgt cgccgacctc acacttgccg acttcggcaa
2527621 tacccgcagc tacggcggcg gattattgat ctgccccaac gccgaccact cggacggcct
2527681 gctcgacatc accatggccc agtcggattc ccgtaccaag ttgctccgcc tgttccccac
2527741 cattttcaaa ggcgcccatg tcgagcttga cgaggtgagc accacacgag ccaagacagt
2527801 ccacgtcgag tgccccggta tcaacgtcta tgccgacggc gacttcgcct gcccgttacc
2527861 agccgagatc tccgcggtgc cggccgccct tcaggttctt cgcccccgcc acggataagc
2527921 gggtggtaac gactcggtcg taaagcgcga catccttcca aacccgctgt acgggaggaa
2527981 cagatgtccg gacaccgcaa gaaggcaatg ctcgccttgg cggctgcgtc gctggcagcg
2528041 acgctggccc cgaacgcagt cgcggccgca gaaccgtcgt ggaacgggca gtacctcgtg
2528101 acgttgtctg ccaacgcgaa aaccggcacc agcatggcgg ccaaccggcc agagtatcca
2528161 cacaaagcga actacacgtt cagctcgcgc tgcgcgtccg atgtctgcat tgccaccgtg
2528221 gtcgacgctc cgccaccaaa aaacgagttc atcccgcggc caatcgaata cacctggaat
2528281 gggactcaat gggtacggga gatcagctgg caatgggact gcctgctacc cgacggcaca
2528341 atcgaatatg ccccagccaa atcgatcacg gcctacacgc ccggtcagta cggaatcctc
2528401 accggcgtct ttcataccga tatcgccagc ggcacgtgta aaggcaatgt cgacatgcca
2528461 gtgtcggcca aaccgatcgt tggctgacgt tgccagccct gccgagcatg ggcggcacat
2528521 cacgcaaacg catggacgac cagcacagcc ccgaatgcgg cgataacggc gttgccggca
2528581 aggactgtca tccgacggac gcgggcggtc gcccgggacc tgagaaacgc tcccgccgag
2528641 acaagcagca actgccagag caacgacgcg agcgctaccc cgaccacaac agcgatcgcg
2528701 gtcgttgcgc gcaacgcgcg cgccagcgtc acggctactg cggtgaagta cacgaacgtg
2528761 gccgggttga tcgccgttag gccgaagatc aacgcaaacc gaacacagcc cagctgtttt
2528821 tgtggggccg gaaccggctc cggcgatgga cgcaacccgt gcccgattcc catcgcagcg
2528881 atgaccagca gcacgatcgc accgacgatt tcgggccaaa ccctcaacac gttgatcgtc
2528941 ggtgccgcaa ctgtctccaa atcgcggtag cgcaatacgc tacgtcgaca agggcgaccg
2529001 ccgcggcggc cggtattcca cgacgccagc cgcgctcaac acctgcttgc cgaggaaagc
2529061 gttcccggtg gcggcatcga ggcgtttgtc gatgtgcgac ttcgaccggc ggaggacagc
2529121 gacgactttc tggcatggtc gagcacggac accacgatcg acgatgccgt ccacgtcacc
2529181 ggaccctacg actacctgct acacattcgg gtctgcgaca cagcggacct ggaccgcctg
2529241 ttacgcaggc tcaagacctc cgcggaagct gcgcaaaccc aaacgcgcat tgcgctcagg
2529301 tcccggcgtt gacaccgcgc cagcaggcgc caccaaaccc ttagccaact ccccgactca
2529361 gccaagtcac ctcgccggcg tcgccgccgt cacgatacac ctcgagcgcc tggtcccagg
2529421 ccgttcccag caccgaatcc agttcggcgg ccagtgtgtc cgcaccttgg gccatcatcg
2529481 cccgcagccg catctccccc accatgatgt cgccgttggc gctcatcgcc ccgctccaca
2529541 gacccagttg cggggtgtga ctgaatcgct ggccgtcgac tccagggcta gggtcttcgg
2529601 tgacctcgaa ccgcagcacc gaccaggaac gcaaggcgtt ggctagtcgc gccccggtgc
2529661 ccaccggccc gacccaatta gtgaccgcac gcaactgcgg cggcagggcc ggttgcggcg
2529721 tccagaccag gttcgccttg gcctgtaggg tcgacgacaa cgcccactcg acatgcgggc
2529781 acaccgccgc gggcgaggcg tggatgtaca ccacaccgga cgtcacgtcg gcgaattggt
2529841 tcgacgctcg catctgctgc tccttcggtt ccacgaggga cgtcttcccc aacgacctgg
2529901 tgaacccgac aagcaggatg cctgctgtga aatttcgaat ttttgtgtcg tgcgtttcta
2529961 ttgtgccttg tgatacccgt gttgcgctag tgtgcggttc tgcctaggtg tactcggcta
2530021 gaaccgcgtc ggaaatcgcg ggccacaagt ccaacgccca gtcgccgaaa tcgcgggccg
2530081 tgaggaccac cagagccagg tccgccttgg gatccaccca gatgaaaccg cctgattggc
2530141 cgaaatggcc gaatgtccgc gtcgagttgc actcgccggt ccagtggggc gatttcgaat
2530201 tcctgatctc aaagcccagc ccccagtcat tgggccgctg cacaccgtac ccgggcagta
2530261 caccgtccag gccgggaaac tgcaccgtgg tcgcgtcggc atgcatctgc gccgagaccg
2530321 tcgatggacg cagcagatca cccgcgaaca ccgccaagtc cgcgaccgtc gaggtcgccc
2530381 cgaacccggc ggcagcgggg cccccgtcca gccgggtggt caccatgccc aggggttcgc
2530441 acaccgcctc ggtcaggtag cgcccgaact cgatccccga ctcccgctgc acgctctcgg
2530501 ccagcacggt gaaaccgtag ttcgaataca tccggcgggt gccggggcgg gccagcgcct
2530561 gatcggaatg catcgccaac cccgatgtgt gcgccagcag gtgacggacc gtggagccgg
2530621 gcgggcctgc cggggtgtcg agattcacca ccccctcctc aacggcgacc tgtgcggctc
2530681 gggccaccag cggcttggtg accgacgcca gcgcgaacac ccgcgcggta tcgccgtggg
2530741 tggctagcac ccctgcgggt ccgatcaccg cggcggccgc agccgggacc ggccagccac
2530801 caagcacttc gagagcggtc atcgactccg gcgcgtcact tccgggcgat gtagtagttg
2530861 ttcaacacgt ccgactcgat ctcggccacc gtcacgtcgg taaaaccggc gtcggcgagc
2530921 atcgaggtgg ccaactgcct gccccacacc gtccccaacc cggccccgtc aagcgccagc
2530981 gacaccgtca tgcagtgcat tagcgaggtc gtgtacaggt aggtgctcag cggaacgccg
2531041 acattgtctt ccagttgact cgatgccttg atgtcgacca tcagcagcac accaccgggt
2531101 cgcagcgcac gatagatgtt ctgcaggacg cgcgccggct gcgcctggtc gtgaatcgcg
2531161 tcgaacacgg tgatcacgtc gtaggccccc accttgtcca gctctgccag gtcatggcgc
2531221 tcgaaggtcg cgtttgccag gcccaaccga gccgcctcct cggtccccgc cgcaacggcc
2531281 tcgtcggaaa agtcgatgcc ggtgaatcgg ctcgcgccga acgcctgcgc catcagcttg
2531341 accgcgcgac cactgccgca accgaaatcg gccacgtcgg ctccggaccg caagcggtcc
2531401 ggaaggccgt cgaccagcgg gagcaccacg tcgatcaagg cggcatcgaa caccatgccg
2531461 ctcatctcgg ccatcagctt gtggaagcgc gggtattcgc tgtagggcac accgccgcct
2531521 tcccggaagc agcgaatgac cttttgttcg acctcgccga gcagcgaaac gaactgtgct
2531581 atcacggcga ggttgtccgg cccggccgca cgggtcagca tgccggcgcg gtgggcaggc
2531641 agcgagtagg tcgagctccc cgcgtcgtat tcgacgatct gcccggtggt catgccgcct
2531701 agccactccc gaacgtagcg ctcttccaac cccgcagcct cagcgatctc catgctggtg
2531761 gctggcggaa gtccggccat ggtgtccagc agcccggtct ggtgtccaac gctcaccagg
2531821 atcgccaaac cggcgctgtc gatggccgca acaaaacggt tgccgaattc ttcggtggtc
2531881 tcgagtgctc cgctcatctg cgccgctcct cctcatcgct tcgctctgca tcgtcaccgg
2531941 cgcgactcat ctgcgccgct cctcctcatc gcttcgctct gcatcgtcac cggcgcgact
2532001 catctgcgcc gctcctgctc atcgcttcgc tctgcatcgt caccggcgcg actcatctgc
2532061 gccgctcctg ctcatcgctt cgctctgcat cgtcaccggc gcgactcatc tgcgccgctc
2532121 ctgctcatcg cttcgctctg catcgtcacc ggcgcgactc atctgcgccg ctcctcctca
2532181 tcgcttcgct ctgcatcgtc accggcgcgc atggtcagcg acgctacacc gtaggttgga
2532241 caccatgagt cagacggtgc gcggtgtgat cgcacgacaa aagggcgaac ccgttgagct
2532301 ggtgaacatt gtcgtcccgg atcccggacc cggcgaggcc gtggtcgacg tcaccgcctg
2532361 cggggtatgc cataccgacc tgacctaccg cgagggcggc atcaacgacg aatacccttt
2532421 tctgctcgga cacgaggccg cgggcatcat cgaggccgtc gggccgggtg taaccgcagt
2532481 cgagcccggc gacttcgtga tcctgaactg gcgtgccgtg tgcggccagt gccgggcctg
2532541 caaacgcgga cggccccgct actgcttcga cacctttaac gccgaacaga agatgacgct
2532601 gaccgacggc accgagctca ctgcggcgtt gggcatcggg gcctttgccg ataagacgct
2532661 ggtgcactct ggccagtgca cgaaggtcga tccggctgcc gatcccgcgg tggccggcct
2532721 gctgggttgc ggggtcatgg ccggcctggg cgccgcgatc aacaccggcg gggtaacccg
2532781 cgacgacacc gtcgcggtga tcggctgcgg cggcgttggc gatgccgcga tcgccggtgc
2532841 cgcgctggtc ggcgccaaac ggatcatcgc ggtcgacacc gatgacacga agcttgactg
2532901 ggcccgcacc ttcggcgcca cccacaccgt caacgcccgc gaagtcgacg tcgtccaggc
2532961 catcggcggc ctcacggatg gattcggcgc ggacgtggtg atcgacgccg tcggccgacc
2533021 ggaaacctac cagcaggcct tctacgcccg cgatctcgcc ggaaccgttg tgctggtggg
2533081 tgttccgacg cccgacatgc gcctggacat gccgctggtc gacttcttct ctcacggcgg
2533141 tgcgctgaag tcgtcgtggt acggcgattg cctgcccgaa agcgacttcc ccacgctgat
2533201 cgacctttac ctgcagggcc ggctgccgct gcagcggttc gtttccgaac gcatcgggct
2533261 cgaagacgtc gaggaggcgt tccacaagat gcatggcggc aaggtattgc gttcggtggt
2533321 gatgttgtga tggccgccat cgagcgcgtc atcacccacg gcaccttcga actcgatggc
2533381 ggcagttggg aagtcgacaa caacatctgg ctggtcggcg acgactccga ggtggtggtt
2533441 ttcgacgccg cccaccacgc ggctcctatc atcgacgccg tcggcggccg caaggtggtt
2533501 gcggtgatct gcacgcacgg ccacaacgac cacgtgacgg tggcccccga actgggcacg
2533561 gcgcttgacg caccggtgct gatgcatccc ggcgacgccg tgctgtggcg aatgactcac
2533621 ccggacaaaa gctttcgcgc cgtttcagac ggtgatgcgg tgcgggttgg cgggacggag
2533681 ttgcgtgcgc tgcacacccc ggggcactcc cctggatcgg tgtgctggta tgcgccagag
2533741 ctgggtcccg gaacaggcac cgtgttcagc ggagacacgc tgttcgctgg cgggccgggt
2533801 gcaaccggcc gctcgtattc cgacttcccc acgatcctgc ggtcgatatc cggacggctc
2533861 ggcgcattac cgggcgacac cgtcgtgcac accggccacg gcgacagcac caccatcggc
2533921 gacgagatcg tccactacga ggaatgggtg gcccgtgggc attgatcccg cgggcgcgcg
2533981 cagaatgccg gtcgtagcgg cgtgtcggtg tacaagcacc gcgcggtcca tgagccgagc
2534041 gctacttatc cgcgcaatct gacactcgag ccaagctgcg gcgcagaaac accgcaaagc
2534101 cggcacccat gaccacaaat gccgtcactg gcacccagtc acccaaccga aggtagagcg
2534161 tgacattcga tgccaacgga acgttcacca cgatggcacc gttgaattcc gccgagcacc
2534221 aggccagccg acggccccgg gtatcaaagg ccgagctgtc gcccgacaag ctggcgtgca
2534281 ccgctgggat gccggcttcg acggcgcgca ccgcgggctg ggcggccaac tgcggctgcg
2534341 cccaactccc ttggaacgtc gaggtggaac tctgatacac cagcagcgcc gccccgagcc
2534401 gcgcggcgtg ccgggtcaga tcggagaagg tcatctcgta gctgatcaac ggggcgatat
2534461 gcaaggagtt caccgccaac accaccggcc cggcgccgcg ctgccgatcc tttgcggcgg
2534521 ccttgctgta gcgggtgatc cagccgaaaa gcgggcgcag cggagcacat attcgccaaa
2534581 cggaaccaac cgggtcttcc ggtagctgcc cacagcttcg tgcgcgccga caagcaccgc
2534641 cgacttgtag attcccccgt ccggtgccgg ggcgtcgacg ttgaccaaca aatccgcgcc
2534701 cacccgctgt gacagctcgg ccaggcgagc caggacgtca ggatggcggg tgaggtcttg
2534761 tccgacgctg ctttcccccc agaccaccaa gtccggccgc tggtccgcaa cggccgcggt
2534821 gaactcttca ccggccgcca gtcgagccgc cgcatcggct atgtcgccgg cctgtaccag
2534881 cgccacgcgc accgtcggac cgccgaccgg caccgagccc agcaggtagg aagccgggcc
2534941 gagtcccgca cacccaatca cgcatcccag cgcgaccagc cggccgcccg ttgcccggca
2535001 cacgagcacg ctcgcgatgg cggtattggt cgcaaccaga agaaaacttg tcagccacac
2535061 cccacccagc gacgccgacg ctagcgtcac gggctggctc cattgcgatg cacccagcaa
2535121 cgcccacgga ccgcccagcg attgccagga ccgcaccgct tcggctgcca cccacgcgct
2535181 gggcaccacg accagggcgg caccgacgcg gcatgtggtc accggtaccg acaacagccg
2535241 gtgcgccaac cacccggccg gcagccacag cacacccagg ccggcggcca acagcaccag
2535301 catcggacca gcactggtca ccagccagta ctgggttgcc agcacaaatc cgcccatacc
2535361 cgtccacgcc cgcagcgcgc cctcccacga cgtcggcgcg gcccgcacca ctaacagcag
2535421 tgggaccaag ccgaaccagg ccagccacca ccaagacggc gcgggaaagg ccagcgcggg
2535481 taacccgccg aacaccaacg ctgccgcaca accaatgacc ggttgtcgcc gggctcccgc
2535541 gcgcaacgcc atgccgatca gcatgccggc cacattcgcc tgcgtcgagg aaaagagcag
2535601 actaagaccg gcagtccccg ccagaaaggg agtgatttgc atggccaagg atctggtcgc
2535661 cacggtgccc gatctttccg ggaagctggc aatcatcacc ggcgccaaca gcggtctagg
2535721 cttcgggctg gcccggcggc tgtcggcggc tggcgccgac gtaatcatgg cgatccgcaa
2535781 tcgcgccaag ggcgaggcgg cggtcgagga aatccggacc gcggttccgg atgcgaagct
2535841 gaccatcaag gccctcgacc tgtcatcgtt ggcgtccgtc gccgcgttgg gggaacagct
2535901 catggctgac gggcggccga tcgacctgct gatcaacaac gccggcgtca tgaccccacc
2535961 ggaacgcgtt accactgccg acggcttcga attgcagttc ggcagcaacc atctcggaca
2536021 cttcgcgcta accgcacacc tgctgccgct gttgcgcgcg gcacagcgcg cgagggtcgt
2536081 ctcgttgagc agcttggcgg cccgccgcgg ccgcatccac ttcgacgacc tacagttcga
2536141 gaggtcgtac gccccgatga cggcctatgg ccagtcgaag ctggcggtct tgatgttcgc
2536201 ccgcgagctg gaccgccgca gccgcgcggc cggctggggc atcatctcca atgccgcgca
2536261 tcctggcttg accaagacca acctgcagat cgcgggaccg tcccatggcc gcgacaagcc
2536321 ggcgctgatg gaacgcttgt acaagacgtc ctggcgtttc gcaccgttcc tctggcagga
2536381 gatcgaagag gggatcttgc ccgcgctgta tgcagccgcc accccgcaag ccgacggtgg
2536441 cgcgttctat ggcccccgcg gccgctacga ggtcgccggc ggtggtgtgc gagaggccaa
2536501 ggttcccgca gccgcccgca acgacgccga tagcaagcga ctttgggagg tctccgagca
2536561 gctcaccggt gtcagctacc cgaaatcgcg ctgaactgcc cgatcccggg aacctgaggt
2536621 attccggggg ggagctgcgg aatctccgga atcggtggga tcggcgggat cggtggaggg
2536681 ctgggggacg tggtcgccgg cggctgcgtg gtcgccggcg gctgcgtggt cgccggcggc
2536741 gcggaagcgg gggtcgtcgg tgccggagtg atgacatcgg tggtcaccgc cggttgcgta
2536801 ttcgtcgttg tcggcggagg cggcaacggc tgctgcagcg gcggcgcggg cccaccggtg
2536861 gctggcgcct gtacgggagg tgcgggctcg gtagtggggc catcggatgc cggcgctggg
2536921 gacgggggcg gtgcggcggt cgtggtcaca cccggcctct gcggggtccc cggcgccgtc
2536981 ggctggtcgc cggtggacaa cccgatcgcc acggcggcac ccaccagcaa caccgccacc
2537041 gtcgtgccgg tgatgatcac ggccggcagg cgataccacg ggattggcgg ggacttgggc
2537101 tcgggctccg catgggcatc gtggtcgaag ctcagcgacg ggcgggccgc tgtgtagcca
2537161 ggggccggcc cgatgtggga gtcctcgtcg gcctccgacc aggccaaagc gggctgcagg
2537221 accgacgccg gcgcatcggc cggcgccgtc gccgtcgccg aggtgaccgc ggtcagcacc
2537281 gttgcgctgg tgtcgccggg tctgcgtgcc gcccacaacg cgccgccgaa agcggccgtc
2537341 aattgcggac gaggcgtcct gaccaccggc acgcagaaac gtccggacag cgtcgtggtg
2537401 actgccggga tatttgcacc accacccacc gaaacgatcg ctaccagctc ggccgtgcga
2537461 attccgctgc gggccagggt ttgttccaag gccctgccca cgctgtccag cgagtcacgg
2537521 attgtgtcct cgagctcgtt gcgggtcaac cggatatccc cgcccaacgc gtcggtcagc
2537581 gtggtcaccg tgcttgacga aagccgttcc ttggctttgc gacattcgat ccgcagctta
2537641 gtcagtgagc cgatcgccga ggtgccggct ggatcgaacg cgcccgtgcc cggtagttcg
2537701 gacatgacgt agctcaacag cgactgatcg atcagatcgc cggagaaagc ctgatggcgc
2537761 accgtcgcgg ccaccggccg atactcgtct gcggcgtcga cgagcgtgat gccggtcccg
2537821 ctgccaccga agtcgcatac cgcgacgatc ccacgggccg gtatgcccgg gtcggcccgt
2537881 atcgcgtaca gcgctgccgc ggcgtcaggg agcagtgaca gtggctgggc cgtactcgaa
2537941 gtcccgtgcg accattccga ggcccgacgc agcgcgctat ccaacgctgc taccgcagcc
2538001 ggcccccagt gggcgggata ggtcaccgtg acacttccgg gaagagcacg accgccggta
2538061 gcggtgtagg ccagcgccag cagtgcgtca gccactagcg cctcgctgcg gtacaccgag
2538121 ccgtcggcag ccacgatgcc gaccgaatct cccacccggt ctacgaagtc ggtgatcacc
2538181 aggcctggct cgtccagcct cgggttctcc gatggcacac cgacctcggg cgggcgctgt
2538241 cgatacagcg tcagcacggg tttacgtgtg atggagtgat cggcagccac agccgctagg
2538301 ttggtgacac cgatcgacaa gcctaatgcc ggtctcgccc ctgttgccat atggcccaat
2538361 ccccgtgtcc ggcggctcgt cgcaaccgcc tacctcgaat tttccgtcat acctatagcc
2538421 aatgtgggcg ccggtgatct ggatagcgac attgccgcaa cgcccggttg gtcagcaaat
2538481 ggtgcccatg ctggcgacca acgggacctc cggcgcggta aggcagccgg gctccagtaa
2538541 tcccagcggc taggccaagg cctcgatgtc gtcggtggcg acgatgccta ccggcttgga
2538601 gccgtgttga gaaatgagtt cggccgtcgg cagcaacctc cccactcagc aatcccagct
2538661 tcaccctaaa cctggcgttc gtacgccacc tagcatctgg tgggtgcgaa cggtgatgtc
2538721 gcgttgagcc gcatcggcgc cacccgtccg gcattgagcg cgtggcgatt cgtcacagtg
2538781 ttcggggtgg tcggcctgct cgccgacgtc gtgtatgaag gggcccgttc gatcaccggc
2538841 ccgctgctgg cttcgttggg agcgaccgga ctggtggtcg gagtcgtcac cggcgtcggt
2538901 gaggccgccg ccttgggctt gcggctggtg tcggggccat tggccgatcg aagccgacgg
2538961 ttttgggcct ggaccatcgc cggctacacc ctgacggtgg taacggttcc gctgctcggc
2539021 atcgcgggcg ccctgtgggt ggcgtgcgcg ttggtcatcg ccgagcgagt cgggaaagct
2539081 gtgcgcggcc ccgccaaaga caccctgctg tcgcacgcgg ccagtgtgac cggccgaggc
2539141 cgcggtttcg ccgtgcacga ggcgctggac caggtcggtg cgatgatcgg ccctctcacc
2539201 gttgccggga tgctcgcgat caccgggaat gcctatgcgc ccgcgctcgg cgtgctgacc
2539261 ctgcccggcg gtgccgccct tgctctgttg ctgtggctgc agcgtcgggt gccccgcccg
2539321 gagtcctacg aggactgtcc ggttgtcctc ggtaatcctt cggcgccgcg accctgggcg
2539381 ctgccggcgc agttctggct gtactgcggg ttcaccgcga tcaccatgct ggggtttggc
2539441 acgttcgggt tgctgtcgtt tcacatggtc agccacggcg tgctggccgc cgccatggtc
2539501 ccggtggtct atgcggccgc aatggccgca gatgcgctga cggccttggc ctcaggcttc
2539561 agctatgaca gatatggcgc gaaaaccctt gccgttctgc cgattctgtc gattctggtg
2539621 gtgctattcg ccttcacgga caacgtcaca atggtggtca ttggcacgtt ggtgtggggc
2539681 gcagcggtcg gaatacaaga gtccacgctg cgcggcgtgg tggccgacct ggtcgccagc
2539741 ccacggcggg ccagcgccta cggcgtgttc gccgcagggc tgggcgctgc gaccgccggg
2539801 ggcggcgccc tcatcggctg gctgtacgac atctccatcg gcacgctcgt tgtggtggtg
2539861 atcgcacttg aactgatggc cctggtgatg atgttcgcga tccgactacc ccgcgtagca
2539921 ccgagctaaa gaagcgatca ggcggcccaa cggaacagca ggttggtatg cgacaacatg
2539981 cttgaccggc acgccaacaa gcacgactgc caccgatcca ggtaagtggc ggccaaggac
2540041 ggtcaaccgg tctaggctcg ccagtattac cccttcaagg gcgaaggggg caggaggatc
2540101 tcgatgggcc tcaacacggc gatcgcgact cgggtgaatg gcacgccgcc gccggaggtg
2540161 ccgatcgccg atattgaact gggttccctg gatttctggg cactcgatga cgacgttcgc
2540221 gatggcgcct tcgccacctt gcgccgcgag gcgccgatct cgttctggcc cacgatcgag
2540281 ctgcccgggt ttgtcgcggg caatgggcat tgggcgctca ccaagtacga cgatgtcttc
2540341 tacgccagcc gtcatccgga cattttcagt tcgtacccca acatcacgat caacgaccag
2540401 acaccagagt tagccgaata cttcggctcg atgatcgtgc tcgacgatcc gcgccatcag
2540461 cggctgcgct cgattgtcag ccgagccttc accccgaagg tggtagcccg catcgaagca
2540521 gccgtgcgtg accgggccca tcggttggtc tcatcgatga tcgccaataa tcccgaccgg
2540581 caggccgatc tggtcagcga actcgcaggt ccactgccgc tgcagattat ctgtgacatg
2540641 atggggattc ccaaggcgga ccatcagcgc atttttcact ggaccaacgt cattctcggc
2540701 ttcggcgatc ccgatctggc caccgatttc gacgagttca tgcaggtttc ggcggacatc
2540761 ggcgcctacg ccaccgcgct ggccgaagac cgccgggtca accaccacga cgatctgacc
2540821 agcagcctgg tcgaagccga ggtcgacggc gagcggctgt cgtcgaggga gatcgcgtcg
2540881 ttcttcatcc tgctggtggt ggccggcaac gagacgacgc gcaacgcgat cactcacggc
2540941 gtgctggcac tgtcccgcta tcccgagcaa cgggacaggt ggtggtctga cttcgacggc
2541001 ctggcgccca ccgcggtcga ggagatcgtg cggtgggcct ccccggtggt ctacatgcgc
2541061 cgcaccctga cccaagacat tgagttgcgc ggcaccaaga tggccgccgg tgacaaggtc
2541121 tccctgtggt attgctcggc caaccgggac gagtcaaagt tcgccgatcc ctggacattc
2541181 gacctagcac gcaaccccaa tccgcatctc ggtttcggtg gcggtggcgc ccatttctgc
2541241 ctgggcgcca acctagcgcg tcgggagatc agggtcgcgt tcgacgaact acgcaggcag
2541301 atgcccgacg tcgtcgcgac cgaggagccc gcacggctgt tgtcgcagtt cattcacgga
2541361 atcaagacgc tgccagttac gtggtcctga aaggccgaac gtggctcggc gggtatatgg
2541421 tgcgccattc ccggtggctg tgggatttgc actacacagg aagcgttgtc gcccacccac
2541481 tggcggaccg gtaggcaccg atcggtgccg gcctgttttg ggtagcggat caagcgcaca
2541541 aacgactcgc ggtggccgaa caggatgatg ttggcgagac gccccgtctg gcatgaccgc
2541601 tgccgacgcg ttcgagtgcg gtcgagagcc aaaggcggct tgatcagccg ccaaccgcag
2541661 gccgaagacg tgccggctca ggtgtgtgac gatcgtagcc gtagcggtcg atgatctcgc
2541721 cccagtgctc atcgacaatc gcacgctgct cgacggtcag ttgatagctg ttggttttgt
2541781 agtccgcatg gtcagctagg tattgccgca gacgcggcag gtaacactcg aagtcgccca
2541841 gtcccaggtg ctggtatagc cggcgcagct gtccctcggg atcaccgatc aaatcctcat
2541901 aacgcaattc gtaaaagcgt gtggggtcaa cgagttctcg gccttcgtcc aactttcggt
2541961 ataggtcgac gtaggtcgac acgaccttgt cgtccaaccc gtcgaacgtc ggttgttgca
2542021 agccatgtat gcggtacagc gccttatgaa gatggatggt tgatggatag accacatagg
2542081 gatctcggac gatgtggatg aacttcgctt gcgggaatac ctccagcagc accttgattc
2542141 gaaaactatg cgttggattc ttgaggatca ccgtcttgcg acggcggaag tacacctgct
2542201 gaacgaaccg gaacagggtc cgtttccaga tttctagttc tcgcggtgcc acctgctcta
2542261 gatccaggta ctcctcatac tggggcggcc ggttcgggaa tgcgatggtc agatacggcg
2542321 acggcaggcc ctgcatacac cacacgaact cgtcttcctg cgggtgatgc aagctcaaat
2542381 ccatgttgtc cattgcccga tgcttcgata ccaggaattc cacatatggc gcaaaccact
2542441 cggtcagtag aaaatggtgt ggcgcaaggc attcgtagcc ggtgggaccg gtgtggcgat
2542501 catcgacgac caacagttca tgcagcaagg tggtgccggt acgccaatgc ccaacaatga
2542561 agattggcgg atcggcgatc accgtttcgg ccactcgcct accgaaaacg atcttctgcc
2542621 acaaccccag acaggaattg accatgctga gaaacgtata gaggaccgcg aagtgccagc
2542681 ggctgtgatg cacggcgaag cggttacgga tcaaaagccg catccaggcc gagaagttgc
2542741 agccgaccca cagcggtgcg gcccactcgc gccaccggga aagtcgagac gacgaacgga
2542801 gagccttcat ggtgcgacgc ggggggtaac ggcgacccgt aaccgggtca agccgcgaag
2542861 gttggcgttt gtcgtccacg tcggcggctc gaccacctct attcggtcga tattggcgac
2542921 gatctcgcgc aagatcgcct gaccctccat gcgcgccagc tgggtccccg gacacaggtg
2542981 gatgccggag ccgaacgcga gatgcccgac cgggttgcgg tcggcgcgaa agacatccgg
2543041 gtcttcgtac tggcgcgggt cacggttggc tgcaccccat gccagcagca ccagtgagcc
2543101 tgccgggatg accgcttgac cgaccgaata gtcgacgcgc gttgtgcggc agatgttttg
2543161 gattggcgat ataaagcgga ggtgctcctc gatcgccgac gggatcaggt ctggttgctg
2543221 cgcaaggagt gtcagctgat ctggatagtc ggccagcgtc agaaacaatg tgctaatcat
2543281 atgagcagtg ctctcatagc ccgcaaccag cagcaacacc gcgaagaaga acaattcgtc
2543341 atcgctgagt cgaccttgct cggcatgggt ggcaagcttc ccgagaacag tgcattccct
2543401 aagcagcccg ttgtcacgcc gatgagtgaa gagtgcacgc aatcgccgga atccggcaaa
2543461 gccctgcaca agcgaaatca acccggaggc tgacaaggca acgtcggtga tccgtaccgc
2543521 ctggttggac aaacggcaga aggcggcctc gtccggtcca tctacgccga gcacactggt
2543581 gatagcgcgc atcggcatcg gtgcggccac ggtggagacg acgtccgcgg gcgtctgggt
2543641 cagtaacccg ccgaccagtt ctcgggcaag ctggtcgacc atcgggcgcc acgtctccaa
2543701 cgcgccacgc gccatacctg gtgccagttg cttgcgcatc cgggtgtgcg ccggcggatc
2543761 ggacgtcggc agaaacggca gccacccccg tgagaaggtg accccacggg cgctggacaa
2543821 cgtgtcgtgg ttacgcgcag cctcgcggac gtcggcgtat cggctcaaaa tgtagacgtc
2543881 gcgcttgggg ttgtactgca cccgctcgcc ggccaacagc tctcgataat gcgggtaagg
2543941 atcagcggca atcgcgggat cgaacgggtc aaagtcggtg agctgcataa atttccggca
2544001 atgccggccg gtcaacctgg accgagcctt cccggcgacc ctcagcgcaa gtgctttcgc
2544061 gaccgcgggc ccgtaggttc gcacagtttg cgcgtcgcgc cacatgctgg tggctaccgg
2544121 gatgccacca gatgacgcgc gccggcgcgt gggaacgccc agagccgtgg tcgcgtcctg
2544181 cgcggtcaga ccaacgtcgg gcgtgcccgc taacgggcac ccggccagcc gcactcggtc
2544241 cggcgcgggc tcgggagggg actgtgtcgc ggtcatgacc ctccgaactc agagaggcgt
2544301 agaacagtca cagggtaacg gcgggcatcg caataattgc gcagtttcgc aaagcgtttc
2544361 gcaacgcaat aagatggtta cccggagttc ggacaggcga atctgcccag cgcaaggctg
2544421 gtgatagcgc cgaccaacgg cgccgtgatc ggtaaccgtt tccgaccggc cgataccggc
2544481 ccggccacca tagcggaggt caaccccacc tgttggcgga acgcccaaaa ctgggccgac
2544541 tgtgtaggca tgcgtcgcac ttgattggtc gccgacccgg caattcgcta gccgcgctaa
2544601 gggtcgcgca tcgttggcca caacaggcgc gacttgcgcg aatgtgcttt ctcgccggca
2544661 tcgcgatgcc taactttatg ttttcgagga gactgcgatg cggcttccag gccgtcatgt
2544721 gttatacgcc ctgtcggcgg tcaccatgct ggcggcctgc tccagcaacg gtgctcgtgg
2544781 cggcattgcg tcgacgaaca tgaatccgac aaacccaccc gcaactgcgg agaccgctac
2544841 cgtctcaccg acaccggctc cgcagagcgc gcgaaccgag acctggatta accttcaagt
2544901 cggcgactgc ctggccgacc tgccgccggc ggatctgagc cggataaccg tcacgattgt
2544961 cgattgcgcg acagcgcatt cggccgaggt atacctgcgt gctccggtgg ccgtcgatgc
2545021 cgccgtcgtt tccatggcca atcgtgattg tgctgccgga tttgcgccct acacaggcca
2545081 atccgtcgac accagcccat actcggtggc gtatctcatc gactcgcatc aggatagaac
2545141 cggggccgat cccaccccga gcaccgtcat ctgtttgctg cagcccgcca acggtcagtt
2545201 gctcaccggg tcggcccgtc gctgaccgga cgacccgttg ttcgggtgcg tggcacacga
2545261 caccaaccgg tatcgtctgt tgccgtgact tctccgattg ctccgaatac caaaagcgac
2545321 ggttctcgct gatgactacc ccacccgaca aggcgcggcg ccggtttctt cgcgacgcct
2545381 acaagaacgc tgagcgcgtc gcacgaaccg ctttgctcac aatcgaccag gaccagcttg
2545441 agcagctgct cgactacgtc gacgagagac tcggcgaaca gccttgtgac cacaccgccc
2545501 ggcatgcgca acgatgggcc caatcacacc gcatcgaatg ggagacgctg gccgagggcc
2545561 tacaagagtt tggtggctac tgcgattgtg agatcgtaat gaatgtcgaa cctgaggcga
2545621 tcttcggcta gtcctctgcc ggcgatgttc tcataacgac atggcaagcc acgcgcttga
2545681 ctaaactcag ccgacgtcaa accgcctgtc cccgatatgc cctgcgaggt tgcctcgtgg
2545741 ctgatgactc aaacgacacc gcgaccgatg tcgaacccga ctaccggttc acccttgcca
2545801 acgagcggac cttcctggcc tggcagcgca ccgctctagg cctgctggcc gcggcggtcg
2545861 ccctggtgca gctcgtcccg gaactgacga tccccggcgc acgccaggtg ctcggtgtgg
2545921 tgctcgcgat tttggcaatc ctcaccagcg gaatgggtct gctgcgctgg cagcaggcgg
2545981 atcgcgccat gcgccggcac ctgccattgc cccgtcaccc cacaccgggc tacctcgcgg
2546041 tggggctctg cgtggtcggg gtcgtcgcgc tcgcattggt ggtagccaag gcgatcaccg
2546101 ggtgaaccgt cactcgacgg cagcgagcga tcgcgggctg caggccgaac ggacgacgct
2546161 ggcctggacc cggacggcct ttgcgttgct ggtcaacggc gtgttgctga cgctcaagga
2546221 cacgcaaggc gccgacgggc cggctgggct gatcccggcc ggcctagctg gtgctgcggc
2546281 ctcgtgctgc tatgtgatcg ctctacaacg ccaacgagca ctttcgcacc gcccgctacc
2546341 ggcacgaatc actccccgcg gccaggtcca catcctcgcg acagcggtgc tggtgcttat
2546401 ggtcgtcacc gcctttgctc aactgctcta gcgcggcgaa cagacgcaaa agcccccgca
2546461 cgcacggagt gtcgggggct tttgcgtcta ctcgccaaat gcgatcgtgg ccgatggcgg
2546521 cgcggacctt cctgtaaatt gccggaattc acgattttgt gcggctagac caacgccggg
2546581 agccagcgtg cctgcgagga taggagcgcc tcggccgatc cgccggcgca gccgttcggt
2546641 cacaacggat ctgacctgct cagcctgcaa gtcaaccaca agaccggtcc aggctgatac
2546701 gcaaaatatg tgagtgtacc cgccgccaca gcggcagcag ctggatcccc cttttggtgg
2546761 acacgagatc cacccaatag gctgggccga tcgggcgata gacattgtca gttcgtgccg
2546821 gcaccctgat cactgacctc aacaccgagc gtcgaccccg tccctatggt ccaaggaaaa
2546881 caatgtcata cgtggctgcc gaaccaggcg tgctgatctc gccgacggac gacttgcaga
2546941 gcccccggtc agccccggca gcgcatgacg aaaatgcgga cggcataaca ggcgggacca
2547001 gagacgactc tgctcccaac tcacggtttc agctaggcag gcgcattccg gaagccaccg
2547061 cccaggaagg gtttctggtt cggccattca cccaacaatg tcagatcatc cacaccgaag
2547121 gagatcatgc tgttatcggg gtatccccgg ggaacagtta cttctcccgc cagcgcctac
2547181 gggatctcgg gctttggggt ctcacgaatt ttgatcgtgt ggacttcgtc tacaccgatg
2547241 tccatgtcgc cgagagttac gaagcgctag gcgattccgc aatcgaagcc cggcgcaagg
2547301 cggtcaaaaa catccgcggc gtccgcgcca agatcaccac cacggtgaac gaactcgatc
2547361 cggccggggc ccggctgtgc gttcgtccga tgtcggagtt ccagtccaac gaggcatacc
2547421 gggagctgca tgcggacctg ctcacgcgcc tgaaagacga cgaggacttg cgcgccgtct
2547481 gccaggacct agtgcggcgc ttcctgtcca cgaaagtggg tccgcggcag ggggcgacgg
2547541 ctactcaaga gcaggtgtgc atggactaca tttgcgccga ggccccgcta ttcctcgaca
2547601 cacctgcgat tctcggagtg ccgtcgtcgt tgaattgcta ccaccaatca ctgcccctcg
2547661 ccgaaatgct ctacgcccga ggatcgggac tacgggcatc gcgcaatcaa ggccacgcca
2547721 ttgttacccc tgatgggagc cccgccgaat gaccgcgacc gttctgctcg aggtcccgtt
2547781 ctctgcacgt ggggatcgga ttcctgacgc cgtcgcagaa ttacgaaccc gcgagcctat
2547841 ccgcaaggta cggaccatta ccggcgccga agcctggctc gtctcctcgt atgcactgtg
2547901 cacacaggtg ctcgaggatc ggcgtttttc catgaaggaa accgccgctg ccggcgcccc
2547961 ccgcctgaac gcgctgactg ttccacccga agtggtcaac aacatgggaa acatcgccga
2548021 cgcgggactg cgcaaggcgg tgatgaaagc gatcacaccc aaggcacccg ggttggagca
2548081 attcctacga gacaccgcga actcgctgct ggacaacctg attaccgagg gcgcaccagc
2548141 cgatctgcgc aatgacttcg ccgacccgct ggccactgcc ctgcactgca aggttctggg
2548201 catcccgcaa gaagacggcc cgaagctgtt ccgtagcttg agtatcgctt tcatgagttc
2548261 ggccgacccg atccccgccg cgaagatcaa ctgggatcgc gacatcgaat acatggccgg
2548321 aattctggaa aacccaaaca tcacgaccgg cctcatgggt gagctcagcc gcctccggaa
2548381 agatcccgcc tactcgcacg tctccgacga actattcgcg accatcggcg tcactttctt
2548441 cggtgccggc gtcatctcaa ccggcagctt cctcaccacc gcgctgatat cgctgataca
2548501 acgcccgcaa cttcggaact tgttgcacga gaagccggaa ctgatcccgg ccggtgtaga
2548561 ggaactgctg cggatcaatc tctccttcgc cgacgggtta ccgcgcctgg ccaccgccga
2548621 catccaggtc ggcgacgtgc tggtccgcaa gggggagctg gtgctggtgc tgctcgaggg
2548681 cgccaacttc gatcccgagc acttccctaa cccgggcagc atcgaactcg accggcccaa
2548741 ccccacctcg cacctcgcgt tcggccgcgg ccaacacttc tgtcctggat cagctctcgg
2548801 tcgccgccac gcacagatcg gcatcgaagc gctgttgaaa aagatgcccg gcgtcgacct
2548861 ggctgtgccc atcgaccaat tggtctggcg cacccgattc caaagacgca tccccgaacg
2548921 ccttccggtg ctctggtagg cttccggaaa ctcacccgag ccatcaccgc aagatttggc
2548981 aagcgttggg acagaacaat ttcgaccttg caccggccga aggcgctgcc ttctaccgaa
2549041 taaaagtacg ggcctccccc aaactccgaa atcgtcagta ccgcacgcaa ttcaaatgaa
2549101 ccgcaccctg acagcgagcg acgttaatga cgccattgtt gggccgccag cggcgagtcc
2549161 acaagtaccg catcgagtcc gattttgtga gccaggcggt agtcgtcgac agttttcacc
2549221 gcgaaaccca tgaccttcat gccggactgc gatctgaaac agtcgaccga ggcctcgtcc
2549281 cacaactcgg cattcaccgc ggagataccg gaccccaacg tgaattcttc ggtgacggtg
2549341 acatcgcgat gcaactcgaa tccggcccac ttcccaggat ccggctgcgg atcacagtga
2549401 tggttcaatg ccatgttgaa aaggcgctgg cgggtcacgt cacgactttc ggcgacctgc
2549461 agtccctcct gccgcgaggc tgcagccgtg atgtcagcgt tggtggaata tacgatcgac
2549521 cgcccggcag caccagtcct ggtcaacacc tgcgcgaccg ctgagaccag cggctgtggc
2549581 ggagtctgct tgaggtctag aaacagagtc atatcgggcg gagtcgcgcc aatggcttgc
2549641 tccagtgtcg gtatcggggt cgcccgttgc cggtagggat ggccctcgac gcccggcgtg
2549701 gtgaaattcc atcccgcgtt gagctgctgg agttgctgaa ccgtcttcga attcaccggg
2549761 ccggcgccgt cggtcaacgt tgccagatcg gacggacgat acagcaccgg cacgccatcg
2549821 ctgctgacct ggacggtcag ccacatgcca tccacaccag ctgcgactgc gttggtaatc
2549881 gccagaacgg tgttctcggg aaaatcgcgc gtacccgcgc gatgcgcgac aatcatcggg
2549941 tcgtcagtct ggcccagcgg caaagcatcc gccacaccgc aagtccctcc caaggcgatc
2550001 accagcgcca ccgtgaaccg ccccggcatg tccggagact ccagttcttg gaaaggatgg
2550061 ggtcatgtca ggtggttcat cgaggaggta cccgccggag ctgcgtgagc gggcggtgcg
2550121 gatggtcgca gagatccgcg gtcagcacga ttcggagtgg gcagcgatca gtgaggtcgc
2550181 ccgtctactt ggtgttggct gcgcggagac ggtgcgtaag tgggtgcgcc aggcgcaggt
2550241 cgatgccggc gcacggcccg ggaccacgac cgaagaatcc gctgagctga agcgcttgcg
2550301 gcgggacaac gccgaattgc gaagggcgaa cgcgatttta aagaccgcgt cggctttctt
2550361 cgcggccgag ctcgaccggc cagcacgcta attacccggt tcatcgccga tcatcagggc
2550421 caccgcgagg gccccgatgg tttgcggtgg ggtgtcgagt cgatctgcac acagctgacc
2550481 gagctgggtg tgccgatcgc cccatcgacc tactacgacc acatcaaccg ggagcccagc
2550541 cgccgcgagc tgcgcgatgg cgaactcaag gagcacatca gccgcgtcca cgccgccaac
2550601 tacggtgttt acggtgcccg caaagtgtgg ctaaccctga accgtgaggg catcgaggtg
2550661 gccagatgca ccgtcgaacg gctgatgacc aaactcggcc tgtccgggac cacccgcggc
2550721 aaagcccgca ggaccacgat cgctgatccg gccacagccc gtcccgccga tctcgtccag
2550781 cgccgcttcg gaccaccagc acctaaccgg ctgtgggtag cagacctcac ctatgtgtcg
2550841 acctgggcag ggttcgccta cgtggccttt gtcaccgacg cctacgctcg caggatcctg
2550901 ggctggcggg tcgcttccac gatggccacc tccatggtcc tcgacgcgat cgagcaagcc
2550961 atctggaccc gccaacaaga aggcgtactc gacctgaaag acgttatcca ccatacggat
2551021 aggggatctc agtacacatc gatccggttc agcgagcggc tcgccgaggc aggcatccaa
2551081 ccgtcggtcg gagcggtcgg aagctcctat gacaatgcac tagccgagac gatcaacggc
2551141 ctatacaaga ccgagctgat caaacccggc aagccctggc ggtccatcga ggatgtcgag
2551201 ttggccaccg cgcgctgggt cgactggttc aaccatcgcc gcctctacca gtactgcggc
2551261 gacgtcccgc cggtcgaact cgaggctgcc tactacgctc aacgccagag accagccgcc
2551321 ggctgaggtc tcagatcaga gagtctccgg actcaccggg gcggttcacc gcgcccaaca
2551381 tagccgtctt caccatcggt ccccttcagg ctttccccac cgtagaaacg tgcgcaatgc
2551441 gcggcgcaca gtatcgaacc gtaccgctga gagccaacca cgatgatttg cccgcaccgg
2551501 cagcgataaa gtaagtcgcg gtcgggcacg cagcgcagcg ttggaaagtg aggcctccga
2551561 tgagtgaaat gacagctcgg ttttccgaaa tcgtcgggaa cgccaatttg ctgaccggcg
2551621 acgcaatccc cgaggactac gcacacgacg aagagttgac ggggccgccg cagaagccag
2551681 cctatgccgc caagccggcc acccccgaag aggttgccca actgctgaag gccgcctctg
2551741 aaaacggtgt gccggtgacg gcccgcgggt ccgggtgcgg cttgtcgggg gccgcacgac
2551801 cagtcgaggg tgggctgctg atctcgttcg accggatgaa caaggtcctc gaggtcgaca
2551861 ccgccaacca agtcgccgtc gtgcagcccg gggtggcgtt gaccgacctg gacgccgcta
2551921 ccgccgatac cgggctgcgg tacacggttt acccgggcga gctgtcctcc agcgtcggcg
2551981 ggaatgtcgg aaccaacgcc ggcgggatgc gcgcggtcaa gtacggagtg gcccgccata
2552041 acgtgctcgg gttgcaagcg gtattgccca ccggcgagat catccgaacc ggcggcagga
2552101 tggccaaggt gtccaccggc tacgacctca cccagctgat catcggctcg gagggcaccc
2552161 tggccttggt caccgaggtg atcgtcaagc tgcatccgcg gctcgaccac aacgccagcg
2552221 tgctcgcccc gttcgccgac ttcgaccaag tcatggcggc ggtgcccaag atcctcgcca
2552281 gcggcctggc acctgacatc ctggagtaca ttgacaacac ttcgatggcc gcactcatct
2552341 ccactcagaa cctggagcta ggtattccgg accagatccg cgacagctgc gaagcttatc
2552401 tccttgtggc gcttgagaac cgcatcgccg accgactgtt cgaggacatt cagacggtgg
2552461 gtgaaatgct catggaattg ggagcggtgg acgcctacgt gctcgaagga ggctcggcgc
2552521 gcaagctgat cgaggcccgc gagaaggcat tctgggcggc aaaagcactc ggcgccgacg
2552581 acatcatcga caccgtcgtc ccacgcgcgt cgatgccaaa attcctgagc accgcgcgcg
2552641 gtctggcggc ggcagcggac ggtgccgcgg tcggttgcgg gcacgccggc gacggcaacg
2552701 tacacatggc catcgcgtgc aaggatccgg agaaaaagaa gaagctcatg accgacatct
2552761 ttgctctcgc aatggaattg ggtggcgcga tctctggcga acacggcgtc ggccgggcca
2552821 aaaccggcta tttcctcgag ctggaagacc cggtcaagat cagcctcatg cgccgtatca
2552881 agcagagctt cgatccggcg ggcatcctca acccaggcgt tgtcttcgga gacacctgag
2552941 cacggacaag agccggccgg accaaggccg gtcatcggcc ggccaacagg cctgcaagtc
2553001 tcgagcgcaa catcttcgtg gacagctcgg tccgccggtc gtcaaagccg atttccccgc
2553061 atctgtccgg tcagtccgat gcagcgtcgg tcaccgttat tcatccggcg tttacccgtt
2553121 gctagccgcc atgacgtagc ctgctgacgc tcgatcgcca acacaagccg acatgagcga
2553181 caatgccaaa caccacaggg atgggcattt ggtggctagc ggacttcagg atcgcgcagc
2553241 gcgcacaccg caacacgagg gcttcctcgg gccggaccga ccatggcacc tgtcgttcag
2553301 tctgctgctg gcgggttctt tcgtgctgtt ctcgtggtgg gcattcgact acgcagggtc
2553361 cggcgcgaac aaagtcatcc tggtgctcgc caccgtcgtc ggcatgttca tggccttcaa
2553421 cgtcggcggc aatgatgtcg ccaactcgtt tggcaccagc gtcggcgcgg gcacgttgac
2553481 catgaaacag gcgcttctgg tcgcggcgat cttcgaggtc agcggcgcgg tgatcgccgg
2553541 cggcgacgtc accgagacca tccgcagcgg catcgttgat ctgtccgggg tgtccgtcga
2553601 cccacgcgac ttcatgaaca tcatgctgtc ggcgctatcg gcagccgcgc tctggctgct
2553661 gtttgctaac cgtatggggt acccggtgtc gaccacacac tcgatcatcg gcggcatcgt
2553721 cggcgcggcg atcgcgctgg ggatggtgag cggccagggc ggtgccgcac tcaggatggt
2553781 ccagtgggat caaatcggcc agatcgtggt gtcctgggtg ctgtcgccgg tgttgggcgg
2553841 cttggtgtcg tacctgctct acggcgtcat caaacggcac atcctgctgt acaacgaaca
2553901 ggccgaacga cggctaacag aaattaagaa agagcgcatc gcacaccgcg agcgccacaa
2553961 ggcggcgttc gaccggctca ccgagatcca gcagatcgcc tataccggcg ccctggcgcg
2554021 cgacgccgtc gcggcaaacc gcaaggactt tgatcccgac gaactggaat ccgattacta
2554081 ccgcgagcta cacgaaatcg acgccaagac atcgtcggtc gacgcgttcc gggccctgca
2554141 gaactgggtt ccgctggtcg ccgccgccgg atccatgatc attgtcgcga tgctgctgtt
2554201 caaggggttc aagcacatgc acttgggcct taccacgatg aataactact tcatcatcgc
2554261 gatggtcggt gcagcggtgt ggatggccac ctttattttc gccaagacac ttcggggcga
2554321 atcactttca cggtcaacgt ttttgatgtt cagctggatg caggtcttta cggcctcggg
2554381 cttcgccttc agccacggca gcaatgacat tgccaacgcc atcgggccgt tcgcggcaat
2554441 cctggatgtg ctgcgcacgg gcgccattga aggcaacgca gcggtgcctg ccgcggccat
2554501 ggtaacgttc ggcgtcgcgt tgtgcgcggg gttgtggttc attggacgac gggtgatcgc
2554561 caccgttgga cacaacctca ccacgatgca cccggcatcg gggtttgctg ccgaattgtc
2554621 ggccgccggg gtggtcatgg gagccacggt cctgggtctt ccggtttcca gcacgcacat
2554681 tcttatcggc gccgtcctcg gcgtcggcat cgtaaaccgg tccaccaact ggggactgat
2554741 gaaaccgatc gtgctagcgt gggtcatcac gctgccttcg gcggcgatcc tcgcctcggt
2554801 cggtcttgtc gcgctacgcg cgattttctg acgacgccgg gtccatcaac cccagcgcaa
2554861 cctccgcgag cagtcgctaa agcccccgac acgccgtgcg tgcgggggct tatgcgactg
2554921 ctcgccggac ggaggtccta cgtgctgcgg gaagtgatgt ggctgagcag gtctcgtatc
2554981 gcacccgccg gcggggtgcg cccaccgacc cagatggctc gaagctggcg ccgcaggttc
2555041 aacgcgggga tgtcgaccgc gagtaatcga ccgaacgcca ggtcatcggc tatcgctagc
2555101 cggctcatcg cagccggtcc agcgccggcc aagaccgcgg cccgcacggc cgcagccgat
2555161 gataattcca gcaccggtgg cgcttgctgc atgtcctccc cgagcgtgtc acgtaacgcc
2555221 gcggtgagtg aatcgcggat gccagagttc ggttcgcgag tcaccaaagg cgtctgagcg
2555281 agctcccggg cgctcactac tcgtgaccgt cgggcccact tgtgacccgg cggcacgacg
2555341 acgaccagtt cgtcgcgtgc aaccacaacg ctgcctaatc ccgtgggagg acaggggttt
2555401 tcgatgaatc caagatctgc gatgccgtca cgaacggctg cgatcgcatg ctcgctattg
2555461 gtggcggtca ggattacctc agggacagta ccaccgcggc gcatgtcggc ggcccgcaag
2555521 gacagcatcc aatgcggcat cagctgttcg gctatcgtct ggctggccac cactctgatg
2555581 cgctggcggc cttcggtgcg cagcgagccg aggccggcat cgatctcgtc ggcgacttcg
2555641 agcaagcggg ccgcccattc ggcgacgacg atgccggcag gcgtgagttg ggagccacgt
2555701 gtcgtccgga tggccaatcg caccccgatc tgggcctcca tcgatgcgag ccgccttgac
2555761 acagcttgtt gagtcaaccc gagttcgcgt gcggcgccgc caagactgcc ggcctcagcg
2555821 atggccagaa agatttcgaa gcaggtgagt ccgggcatac gagagctgag cggcatgcct
2555881 gatcaaatca caaccaatgg ttgttcccaa caacattcag acccctagtg acgacggccc
2555941 atgctcgaaa aatgccccca cgcgagcgtc gactgcggtg cctcgaaaat cggcatcacc
2556001 gacaacgacc ccgcgaccgc caccaaccgc aggctggcga gcacaattcg caagccgccg
2556061 atcgagcacg cggccgggcc cttagggtcc acatcacgcg ctggccaccg ttcgtacggc
2556121 ggggtggcct cgtaaggtaa ccacatgggc gctcctcgac tcatccacgt catccggcaa
2556181 atcggggcct tggtggtagc ggcagtgacc gccgccgcca cgatcaacgc atataggccg
2556241 ctggcgcgca acggattcgc atcgctgtgg tcgtggttta ttggcctggt ggttaccgag
2556301 tttccgttac cgacgctggc gagccagctc ggcgggctgg tgttgacagc ccaacgcctg
2556361 acccggccag tgcgggcggt ctcctggctg gtagcggcct tctcggcgct ggggctgctg
2556421 aacctcagtc gcgcaggccg tcaggccgat gcccagctca ccgccgcatt agacagcggc
2556481 ctggggcccg atcgccgcac cgcctcggcc ggtctgtggc gccgcccagc cggcggtggt
2556541 accgccaaga cccccgggcc gctgcgcatg ctgcggatct accgcgatta cgcacacgat
2556601 ggcgacatca gctacggcga atacggcagg gccaaccacc tcgatatctg gcgacgtccc
2556661 gatctagatc tgaccggaac agcgcccgtg ctgtttcaga tccccggcgg tgcatggacc
2556721 accggaaaca aacgcggaca ggcgcatcca ctgatgagcc acctcgccga gctaggctgg
2556781 atctgcgtgg cgatcaacta ccgacacagc ccgcgcaaca cctggccgga tcacatcatc
2556841 gacgtcaagc gcgccctggc gtgggtcaag gcgcacatca gcgaatacgg cggcgatccg
2556901 gacttcatcg ccatcaccgg tggttcggcc ggcggccacc tgtcgtcact ggccgcgcta
2556961 acgccgaatg acccacgatt ccaaccggga ttcgaagagg cggacacccg ggtgcaggca
2557021 gccgtgccgt tctacggcgt ctatgacttc actcgtctgc aggacgcgat gcacccgatg
2557081 atgctgccgc tgctggagcg aatggtggtc aaacaaccgc gcacggcgaa catgcagtcc
2557141 tacctcgacg cctcaccggt cacccacatt tccgccgacg ctcccccatt ctttgtgcta
2557201 cacggccgca acgactcgct ggttcccgta cagcaggcgc gtggcttcgt cgatcagctg
2557261 cggcaagtca gcaagcagcc ggtggtatac gccgaattgc cctttaccca gcacgctttc
2557321 gacctgctcg gctcggcacg tgcggcacac acggcgatcg ccgtggagca attcctggcc
2557381 gaggtctacg caacgcaaca cgcgggcagt gagccgggcc ccgcggttgc gatcccatag
2557441 cttttggggt tgaggtcgct agggttggcc ttgtgaagct gctcagcccg ctggatcaga
2557501 tgttcgcgcg catggaggcg ccgcgcacgc caatgcacat cggcgcgttt gcggtcttcg
2557561 acctgcctaa gggagcaccg cgcaggttca tccgcgacct gtacgaggcg atctcacaac
2557621 tggcgttcct gcccttcccg ttcgacagcg tgatcgccgg cggcgcgtcg atggcgtact
2557681 ggaggcaggt gcagcccgat ccgagctacc acgtccgctt gtccgcccta ccttatccgg
2557741 ggaccggccg cgatctcggc gcgttggtcg agcggctgca ttcgacccca cttgacatgg
2557801 ccaagccgct atgggagttg cacctcatcg aggggctaac cggccgtcag ttcgccatgt
2557861 acttcaaggc ccaccactgc gcggtcgacg gattgggtgg ggtgaacctg atcaagagct
2557921 ggctcaccac cgatcccgag gcacccccag gctcgggcaa gcccgagccg ttcggcgatg
2557981 actacgactt ggccagcgtg ttggccgccg ccacgacgaa gcgggcggtc gagggcgttt
2558041 ccgcggtcag cgaactggcc ggaaggctat ccagcatggt gctgggcgcc aacagctcgg
2558101 tgcgggcggc cctcaccacc ccgcgtaccc cgtttaacac ccgcgtcaac cggcatcgac
2558161 ggctagcggt gcaagtgctg aaactgccgc gcctcaaggc agtggcccac gccaccgact
2558221 gcaccgtcaa cgacgtgatc ctggcgtctg tcggcggggc ttgccgacgc tacctgcagg
2558281 agctgggcga cctgccgacg aacaccctga ccgcctcggt gccggtcggc ttcgagcgcg
2558341 acgcagacac ggtcaacgcc gcctcgggtt tcgtcgcgcc gctgggcacc tcgatcgaag
2558401 acccggttgc gcggctgacc acaatctcgg cgtcgaccac ccgcggcaag gccgaactgc
2558461 tggcgatgtc accaaatgcc ttgcagcact actccgtatt cggcttgctg ccgatcgcgg
2558521 tggggcagaa gaccggcgca ctcggggtga ttccaccgct gttcaacttc accgtctcca
2558581 atgtggtgct ctcgaaggac ccgttgtatc tttcgggcgc caagctggat gtgattgttc
2558641 cgatgtcgtt cctgtgtgac ggctatggcc tcaacgtgac gctggtcggc tacacggaca
2558701 aggtcgtcct cggctttctg ggctgccgtg acaccttgcc gcatctgcag cggctagcgc
2558761 agtacaccgg cgcggcattc gaggaactcg agaccgccgc cttgccatag cgaccaaacg
2558821 acgacaacgc tccgcccatc gccggcagta cccgccaatc accacggtgt agccgctcag
2558881 gagcggcccg ccagccggtc gatatcaacg atctccccgc gattgatgct cacccaatcg
2558941 cgcccatcga ggtaggggcg tagctgctgg gcaatgagtt caacatcggc tggtgacttc
2559001 ggtcgctgaa gttcgtagac gtgcggcagc cccgccatgc ccgtgacgac gctccacagg
2559061 ttcagggcgg ccggtccagc aggcgggtcc accagcaccg gcccaaaaag gcattgtccg
2559121 tccaaaaaga gcgtcggcac gccgtatccg cccgcggcga caacccgttg gtggtcggcg
2559181 cggacgtcgt cgtgggtcgt cggatcatcc agcgccgcgt ccaaaatcgc cgcattgacg
2559241 ccgacgtcgc acagtaggcg tcgcgccacc gcgggatcat gcggtttgcc gcccagggtg
2559301 tgcagctcat gaccgatcgc tgcataccac cgatcaagca acgacatgtt cgttcgacgc
2559361 agcagcgcac cgatccgcat caacgaccag ccataggacc agtctcgctc ccacgggtgc
2559421 ttcttgcccg ctaccaggtt gatctcctcg aggctgaaaa accgccagtt gatcgtgatt
2559481 cccaattgcg cgcgcacatc acggatccac accgaggtct gataggcgaa cgggcacaaa
2559541 gggtcaaagt ggaaatccac ggtggtcatc agacctgagt cctccagctg atcgagtcga
2559601 cacctcgatg acattgtgcc gtgcgccacg ttgtcagcgg actgagtcga cccaacatct
2559661 cgcggtgttc gccagggtgc cgaaacaggt caacgcggcg gtatgaatgg tcgacgcacc
2559721 ataggcgagg atgggctggt gttcgggctc gtcgttatcg ttgcgctggt cgccgccgtg
2559781 gtcgtgggga ccgtcctggg ccaccgctat cgcgtgggcc ctccagtgtt gctcatcctg
2559841 tccggttccc tgctgggtct gattccccgt ttcggtgacg ttcagatcga tggcgaggtg
2559901 gtgctgctgc tgttcctgcc ggcgatcctt tattgggaga gcatgaacac cagctttcgc
2559961 gagatccgct ggaacctgcg cgtcatcgtc atgttcagta tcgggctggt gattgccacc
2560021 gcggtcgcgg tgtcgtggac ggcacgagcg ctgggcatgg agtcccacgc cgcggctgtc
2560081 ctcggtgccg tgctctcccc caccgatgcc gcggcggtgg ccggcctggc gaaacggttg
2560141 ccgcgccggg cgctgacagt gctacgcggc gagagcctca tcaacgacgg gaccgcgctc
2560201 gtgctgttcg ccgtcaccgt ggcggtcgcg gaaggtgccg ctgggatcgg cccggccgcg
2560261 ctggtcggcc ggttcgtcgt ctcctatctc ggcggaatca tggccgggct gctggtcggc
2560321 ggcctggtga cattgctacg ccgcagaatc gacgcaccat tggaggaggg agccctgagc
2560381 ttgctgacgc cgttcgcagc gttcttgctc gctcaatctc tgaagtgcag cggtgtggtt
2560441 gcggtgctgg tttcggccct ggtcctcacc tacgttggtc cgacggtgat acgcgctcgt
2560501 tcccgcctgc aggcgcatgc gttttgggac atcgccacgt tcctgatcaa cggctcgttg
2560561 tgggtgtttg tcggcgtcca gatcccgggc gcgatagacc acatcgccgg cgaggacggg
2560621 ggactaccac gggccacagt cctggccctg gcggtgacgg gtgtcgttat cgccacccgg
2560681 atcgcctggg tacaggcaac cacggtcctg ggtcacaccg tggaccgggt cctgaagaag
2560741 cccacccgcc acgtcggctt ccgtcagcgt tgcgtcacaa gctgggccgg tttccgcggc
2560801 gcggtatcgc ttgccgcagc gctggcggtg ccgatgacca ccaatagcgg cgctccattc
2560861 ccagaccgca acctgatcat cttcgtcgtc tcggtcgtca ttctggtcac cgtgctggtc
2560921 caagggactt ccttgcccac cgtcgttcgg tgggcgagga tgcccgaaga cgtcgcgcac
2560981 gccaacgaat tgcagctggc ccgcacccgt agcgcccaag ccgccctcga cgctttgccg
2561041 acggtcgccg acgaactcgg ggtcgccccc gatctcgtca aacacctgga aaaggaatac
2561101 gaagaacgcg cggtgctcgt catggccgat ggcgccgact ccgcgaccag cgatctggcc
2561161 gagcgcaacg atctggtccg gcgcgtgcgt ctaggcgtgc tgcaacacca gcggcaggcc
2561221 gtcaccacgt tgcgcaacca aaacctcatc gacgacatcg tgctgcgcga gctgcaggcg
2561281 gcgatggatc tagaggaagt gcaactcttg gaccccgccg acgccgagtg agccggcgcc
2561341 gcccgctgat cgaaccagca acggttcagg ttttggccat tgctttcaca gactcattca
2561401 gcgtttcatt gcactggccg cagcgcgagc agggctgccg cacagcgatc ttggcgccta
2561461 tgcgaaggtg gtgcgatggt gatgtggacg ggcgaaagtt actgccaccg gcacgccgca
2561521 ctggcaccca acagaggagg atcaggcccg ccgcacccag ggtctacacg accggcgaca
2561581 tcctgcgtga tcggaagggc atagcgccat ggcaggaaca acgcgaaccg ggctgggcgc
2561641 cgttcggttg gctgcacgag ccctcgggcg caaggtgccc aaaagccgac gggcagtcag
2561701 tctaagtgtc ttgataggtg cggtgatagc agctcttgcc ggggcgctga ttgcggtaac
2561761 cgtaccggcg cggccgaatc gccctgaggc cgaccgtgaa gcactgtgga aaatcgtgca
2561821 cgaccgttgc gaattcggct atcggcgtac cggtgcgtac gctccctgca cattcgtgga
2561881 tgaacagtct ggaacggcgt tgtacaaagc ggattttgat ccgtaccagt tccttttgat
2561941 cccgcttgct cgtatcaccg gaatcgagga tcccgcccta cgggagtcag cgggtcgcaa
2562001 ttacctctac gacgcttggg ccgcacggtt cctcgttacc gcgcgcctga acaactcact
2562061 tccagagtca gacgtagtcc tcaccatcaa cccgaagaac gcgcgcactc aggatcagct
2562121 gcacatccac atatcgtgtt cgtcaccaac aacatcggca gccctgagga acgtggatac
2562181 ctcagagtac gttggctgga agcagctccc catcgacctc ggtggtcgca ggtttcaagg
2562241 attggcggtt gacacgaagg cgttcgaatc caggaacctg ttccgggaca tctacctgaa
2562301 ggtaaccgct gacggcaaga aaatggaaaa tgcatcgatt gcggttgcca acgtagcgca
2562361 ggaccaattc ctgctgctct tggcagaggg aactgaggac cagcccgttg cagccgagac
2562421 tctccaagac cacgactgct ccatcaccaa gtcctgatag cacgatgcca gcgggccaca
2562481 cgacagggcg cagtgtgcga acctgacccc gccacggcgg gccgttgatg gcattttgct
2562541 agtgtcggag cggcaatccg cctatatttc tcctcgccta ccagtgaggg agccgggctt
2562601 gactgatccg cgccacaccg ttcgaatcgc tgtcggagct accgcgctcg gcgtgtcggc
2562661 actcggggca actctgccgg cctgctccgc acacagcggg ccgggttctc cccccagtgc
2562721 gccgtcagct cccgcggccg cgaccgtcat ggtagaggga catacgcaca caatttccgg
2562781 agtggtcgag tgccgcacct cgccagcggt aaggacggcg acgccgtcgg agtcggggac
2562841 tcaaactaca cgggttaacg cacacgacga ttcggcctcg gtgacactgt ccctgtccga
2562901 ctccacgccc ccagacgtca atggttttgg tatctccctt aaaatcggaa gcgtcgacta
2562961 ccagatgccc taccagccgg ttcagtcccc aactcaggtc gaagcgacca ggcagggcaa
2563021 gagttacaca ctgaccggga cgggtcacgc ggtgatcccg ggccaaaccg gcatgcgtga
2563081 gctgccgttc ggggtacatg taacctgtcc gtaactacac tgattgcgcg acaagggaat
2563141 tagccgcgtt ggcaggcaac acggaggtga ccggtgcaag cccgtggtca ggtcctgatc
2563201 accgccgcgg aactggctgg catgatccag gccggcgatc cggtgtcgat cctggatgtg
2563261 cgctggcggc ttgatgaacc tgacgggcat gcggcctacc tacagggtca cctgccggga
2563321 gcggtatttg tgtcactcga ggacgaactg agcgatcata cgatcgccgg ccggggccgg
2563381 cacccgctgc cgtcgggggc tagtctgcaa gccaccgtcc gccgatgcgg aatccgacac
2563441 gatgtgccgg tcgtggtcta cgacgactgg aatcgagccg gttccgcgcg agcgtggtgg
2563501 gtgttaactg cggctgggat cgcgaatgta cgcattctag acggcggctt gcccgcgtgg
2563561 cggtccgcag gcggcagcat cgagaccggc caggtcagcc cgcagctcgg gaatgtgact
2563621 gtgctgcacg atgatttgta tgccggacag cggctaaccc taacggcgca gcaagccggt
2563681 gcgggtggtg tgacgctgct cgatgcgcgc gtaccggaac gtttccgcgg cgatgtcgag
2563741 cccgtggatg cggttgccgg tcacatcccc ggcgccatca acgttcccag cggtagtgtc
2563801 ctggccgacg acggcacgtt ccttggcaat ggcgccctta acgcactgct gtccgaccac
2563861 ggcatcgatc acggtggccg cgtgggtgtc tactgcggct cgggtgtcag cgcagctgtc
2563921 atcgtcgcgg cactggcagt gatcggccag gatgcggagc tgtttccagg gtcatggtcg
2563981 gagtggagtt cggatccgac ccgtcccgtc ggccgtggca ctgcatagtc agacgccggc
2564041 ccagttctgc aggaaggctt cggtgacccg ggcggcgttg ttggccgcaa tctgcttgta
2564101 aacgaagaac tggacgggga agcccggcag atgcagcggg tcgccgggcc cgtcggacat
2564161 accgcgaatt cccaggaacg ggacgccgtg tgcatcggcg accgcctgcg cggctgccgt
2564221 ctcctggtca accgcgtcga agccggggtt caccgtcgat acgatgttca ggttgctgat
2564281 cagagcgttc ttcagccagg gtcccgccgc ctggaaaaag ttaccggtat agccaagtga
2564341 gcgatcgggt gcactacagg gttggcagca aaaacgctgc cgccgttcgg gatgcaagga
2564401 aaagcctggc cgttgttctt gtcggagcta gacccgtcac cgccgacgaa cagttgcggc
2564461 tggcgcccca ggtggttcaa ccggacgacc ggaacgttcc tgcacagaca gacaggattg
2564521 ccgagcgtgt tgatgttgtc cagtacaaca gaaagcgtct gggcagtagc cagcatgccg
2564581 ggatcgaccc cacggaatgt tgccccgttg tccagggtcc accgtgctgg tattgccacg
2564641 tccccaatgc tggtgcggcc ggcaccaccg gcgacgcccg agaacatcac ggcggcaatg
2564701 gcaatggaag aagcacaggt aaagcgtgcg aaggcggtct cggtggtgtt ggtagcgttc
2564761 actaggccga tgccggtcat cgccacaatc accttcttgc cgctgatcga gcccaggtag
2564821 tagcgacgac ggtcggcgac caccaccggg ttggcgtcca gcgcggtgtg cgccagcacc
2564881 gcgtcggcct cagccggaaa cgccgacaag accagcgtgc gctgttcgca cgggatcaca
2564941 tttgccacgt atccgggatc ggccgccgcc acgccacagc ccagcgacaa cgcggccgcc
2565001 accaaaagac agtgccgcaa aggcgcgccc acaatccctt atccccaaaa atcgtgattt
2565061 gacatggatg ccggaactct ctgtcattta gccgtggccg atttggggct tggccctgat
2565121 tttcgcgcac catcggcgac ggacgaatat ttgttatcgt ttttttcgtc tagcgattcc
2565181 tcggcgttat ttcatcgcgg cggaacgagc cgccctatga ccaactgtgc aagcgtgatt
2565241 ggtcgatagc cccggtcggg ctatgttccc cggtgtggct agaccagttg accggtgcgg
2565301 gacgcggata cggctagtct gccggagtga tacctaaccc actcgaggag ctaacgctcg
2565361 agcaactgcg aagccaacgc acgagcatga agtggcgtgc gcacccagcc gacgtcttgc
2565421 cgttgtgggt cgcggagatg gacgtgaagc ttccgccgac ggtggccgat gccctccgta
2565481 gagctatcga cgacggcgac accggatatc cctatggaac ggagtatgcc gaagccgtcc
2565541 gcgaattcgc ttgccaacgt tggcaatggc acgacctgga agtgagccgc acggccatcg
2565601 ttcccgacgt catgctcggc atcgtcgaag tgctgcgtct gatcaccgac cgcggtgacc
2565661 ctgtgatcgt caactccccg gtatatgcgc cgttctacgc tttcgtgtcg catgacggcc
2565721 gccgagtgat cccagcgccg ctgcggggag acggccggat cgatttggac gcgctgcagg
2565781 aagcgttctc gagcgcgcgt gcttcaagcg gctcgagcgg caacgtcgcc tacctcctgt
2565841 gcaatccgca caacccgacg gggtcggtgc acaccgccga cgaactgcgc ggcatcgcgg
2565901 aacgcgccca acggttcggt gtccgggtgg tgtccgacga gattcatgcc cctcttatcc
2565961 cgtccggggc acggtttacg ccctatctga gcgtccccgg tgcggaaaac gcattcgcac
2566021 taatgtcggc ttccaaggcg tggaatctcg gcggactcaa ggcagccctg gccattgccg
2566081 gtcgcgaggc ggcggccgac ctcgctcgga tgcccgagga ggtcggtcac ggccccagcc
2566141 acctgggtgt catcgcgcac accgcggcgt tcaggactgg tggcaactgg ctcgacgcgc
2566201 tgctgcgcgg tctggaccac aatcgaacgt tgctaggcgc tctggtcgac gagcatcttc
2566261 ccggggtgca ataccgatgg ccgcagggta cttacctggc gtggctggat tgccgagaac
2566321 tcggcttcga tgacgcggct agcgacgaga tgaccgaagg cctggcggtg gtgtcagatc
2566381 tgtccgggcc agcccgctgg ttcctcgacc acgcgcgggt tgcgctcagt tctggtcacg
2566441 tcttcgggat tggcggtgcc gggcatgtgc gcatcaactt cgcgacctcc cgagccattc
2566501 tcatcgaggc ggtatcgcgg atgagccggt cactactcga gcgccggtag cgcgtccaga
2566561 gaaccgctag cgccaacacg atcacctcgg gtgacggtct tgtccgctcg gcggcccttc
2566621 agtgcccagc caatgcggcc gaccccgcgg cggccgcatt cggtagacaa aggaagtctg
2566681 acaccgtagg cgcctcgttg atcgcgtttt cgccgagaaa cgtgaaggcc gtttgcccgc
2566741 ccgtgcggat cagctacgat caaggcgaca catggaccag tcggccaacc atgcgtgtct
2566801 gcccaccccg ctggcgagca caacagggcg cgggcaagat catgagatgc ctgtcgaaga
2566861 gacctccacc ccccagaagc tgccccaatt tcgttatcac cccgatcccg tcggcaccgg
2566921 ctcgatagtc gccgacgagg tgagctgcgt gagctgcgag caacgtcggc cctacaccta
2566981 caccggcccg gtgtatgcgg aggaggagct taacgaggcc atctgtcctt ggtgtatcgc
2567041 agatggcagt gcggcgagtc gcttcgatgc cacgttcacc gacgccatgt gggcggtgcc
2567101 cgacgacgtt ccagaggacg tgaccgagga agtgctgtgc cgaacacccg ggttcacggg
2567161 ctggctgcag gaggaatggt tgcatcactg cggggacgcc gccgccttcc ttggcccggt
2567221 gggcgccagc gaggtggccg acctccctga cgccctggat gcgctgcgca atgagtaccg
2567281 cggctacgac tggcccgccg acaaaatcga ggaattcatc ctgacgctcg atcgaaacgg
2567341 gctggcgacc gcctacctct tcaggtgcct gagctgcggc gtccacttgg cctacgccga
2567401 tttcgcttaa cctcggcggc gactgagtcg acgcgagcgc ggatatcgga cgcttttgca
2567461 caacaatggt tccgacgtgg cacagctcag agaggagcag atcatggatg tcctacgcac
2567521 cccagactcc cggttcgaac acctggtggg ctacccgttt gcaccgcact atgtcgatgt
2567581 gacggccggc gacacccagc cgttgcgaat gcactacgtc gacgagggcc cgggcgacgg
2567641 tccgccgatc gtcttgctgc acggcgagcc cacctggagt tatctgtacc gaaccatgat
2567701 tccgccgctc tccgccgccg ggcaccgtgt gctcgcgccc gacctgatcg gcttcggccg
2567761 ctccgacaag ccgactcgca tcgaggacta cacctacctg cggcacgtcg agtgggtgac
2567821 gtcctggttc gagaatctcg acctgcacga cgttacgctc ttcgtgcagg actgggggtc
2567881 attgatcggt ctgcgcatcg ctgccgagca cggtgaccgg atcgcgcggc tggtggtcgc
2567941 caacgggttt ctccccgccg cgcaggggcg caccccactc cccttctacg tgtggcgggc
2568001 gtttgcgcgc tattctccgg tgcttcccgc tggccgtctg gtgaacttcg gcaccgtcca
2568061 cagggttccc gccggggtcc gagccggcta cgatgcacct ttccccgaca aaacgtatca
2568121 agccggcgcc cgggcgttcc cacggttggt gccgacctca cccgacgatc cggcggtacc
2568181 ggccaaccgc gcggcatggg aagccctggg ccggtgggac aaaccgttcc ttgccatctt
2568241 cggttatcgc gacccgatac tcgggcaagc ggacggtccg ctgatcaagc acattcccgg
2568301 cgcggcgggt cagccgcacg cccgcatcaa ggccagccac ttcatccagg aggacagcgg
2568361 aaccgaactc gccgaacgca tgctctcctg gcagcaggca acgtaaccgc gacggctgcg
2568421 gacgaaggat cggcagaatg gcgatggaga tggcgatgat gggcctgctc ggcaccgtgg
2568481 tgggtgcctc ggccatgggc atcgggggga ttgcgaagtc gatcgcggaa gcgtatgtcc
2568541 cgggggtcgc ggctgccaag gaccgtaggc agcagatgaa cgtcgatctg caagcacggc
2568601 gctacgaggc ggtgcgagtg tggcggtctg ggttgtgcag tgccagcaac gcctaccggc
2568661 aatgggaggc cgggtctcgg gacacccatg cgcccaacgt cgtcggcgac gagtggttcg
2568721 aaggtttgcg gccgcacctg cccaccactg gggaggcagc gaagttccgt accgcttacg
2568781 aagtccgttg cgataaccca actctcatgg tgctttcgct tgagattggc cgtatcgaga
2568841 aggaatggat ggtggaggcg agcggccgga caccaaagca ccggggatga ctgcgaagac
2568901 tcgcggttgg tagcgcaccc ggctggtgcg gcgccgacaa gctgcccaca ttcggtgaca
2568961 ctgaatttct gcagcaaaag cgcgagtgac caacggtctg cgaaattacc ggctcggggt
2569021 cggctacacc gtcgagcgac gcggtcgccg ccgcgccgag cccctcggta cggtggcaga
2569081 catgaaatat ctggacgtcg acggaatcgg acaggtcagc cggatcgggt tgggcacttg
2569141 gcagttcggc tcgcgtgaat ggggatatgg ggaccggtac gccaccggcg ccgcccgcga
2569201 cattgtcaaa cgcgcacgcg ccttgggggt cacgctgttc gataccgccg agatctacgg
2569261 cctgggcaaa agcgagcgta ttctcgggga ggccctcggc gacgaccgca ccgaggtggt
2569321 ggtggctagc aaggtcttcc cggtcgcgcc gtttccggcg gtgatcaaga accgcgagcg
2569381 cgccagtgcg cggcggctgc agctgaaccg tatcccgctg tatcagatcc accagcccaa
2569441 cccggtggtc cccgattcgg tgatcatgcc ggggatgcgt gacctgctgg acagcggcga
2569501 cattggcgcg gccggtgtct ccaactactc actggcgcga tggcggaagg ccgacgccgc
2569561 gcttgggcgc ccagtcgtca gcaaccaggt acatttctcg ctcgcccacc ctgatgcgct
2569621 cgaagatctg gtgccgttcg ccgagctcga gaaccgcatc gtgatcgcct acagcccgct
2569681 ggcgcaagga ctattgggtg gcaagtacgg actcgagaat cgtcccggtg gcgtgcgcgc
2569741 gttgaacccg ctgttcggca ccgagaacct gcgccggata gagccgctgc tggctacgtt
2569801 gcgcgccatc gccgtcgacg tcgacgccaa gcccgcccag gtggcactgg cctggctgat
2569861 tagcctgccg ggggtggtcg ccattcccgg agcgtccagt gtcgagcaac tcgagttcaa
2569921 cgtcgcggcc gctgacatcg agctcagcgc gcaatcccgc gacgcgctca ccgacgccgc
2569981 ccgggcgttt cgcccggttt ccaccggccg cttcctcacc gacatggtgc gtgagaaggt
2570041 cagccgtcgt tgagctcgct acaaggtacg cgcgagacgt tcggccagca gctcggcgaa
2570101 cctcgccgga tcctcgagtg cgccgccttc ggcgagaagc gctgtgccgt aaagtaattc
2570161 cgcggtttcg gccaatgatt tctcggcatc gtctgcgcgg tcctggtggg cttggcgcag
2570221 gccggtcacc aacggatggc tcgggttgag ctcaagtatc cgcttgccga ccggaacctc
2570281 ctggccggaa gcccggtaga tgcgcgcgag cgcgggtgtc atcccgaagg catcggtgat
2570341 cagacaggcc ggtgactcgg tcaggcgggt ggacagccgc acctccttga cgtgatcgct
2570401 caacgtctcc tgcaaccagg tcagcaggtc ggcaaattcc ttctgccgct cctcgcgctc
2570461 ggcctcgctg gtgtcctctt cggaactcaa gtccacctcg cccttggcaa ccgactgcag
2570521 cggtttgccg tcgaactccg gcaccattcc cacccagacc tcgtcgaccg ggtcggtgag
2570581 cagcagcact tcgtacccct tggccttaaa cgcctccagg tgcggtgact tcagcagttg
2570641 ttggcgcgtc tcgccggtgg cgtagaagat ctgttgctga ccgtccttca tgcgctcgac
2570701 gtattcggcc agcgtggtgg gttcctcctc gctgtacgtg gagacaaacg aagaaatacc
2570761 gagcagggtc tcccggttat cgatgtctga cagcagtccc tctttgagga ccctgccgaa
2570821 ctgtgtccag aacgtgcggt agtcctccgg ccggctggac tgcacgtcct tgatcgtgga
2570881 cagcaccttc ttggtcagcc gccggcggat ggccttgatc tgccggtcct gctgcaggat
2570941 ttcgcgagaa acgttgagcg acatgtcctg cgcgtcgacc acacccttga caaaacgcaa
2571001 gtactcgggc atgagctggt cgcagtcgcc catgatgaac acccgcttga cgtagagctg
2571061 gataccgacg tgggcgtccc ggtcgaacag atcgaacggg gcatgagacg ggatgaacag
2571121 cagggcctgg tactcgaagg tgccctcggc cttcatcgcg atgatctcga gcgggtcgtc
2571181 ccaggcgtgc gcgacgtgtt tgtagaactc cttgtactcc tgctcagaca cctcttcttt
2571241 gggcctcgcc cacagcgcct tcatcgagtt gagggtttcg gtttcgatgg tgacggtctc
2571301 ctcgccgcct tccccccctt cttcctggga ggctggggtg cggcgctcga cgtccatccg
2571361 gatgggccag gcgatgaagt cggagtattt cttgaccagg ttacggatct tccattccga
2571421 ggtgtagtcg tgcaggtcgt cctcggcgtc ttccggcttg aggtgcaggg tgaccgacgt
2571481 gccctggggg gcatcctcga cggactcgat ggtgtaggtg ccctcaccgc tggactccca
2571541 tctggtggcc gcgctctcgc cagccttgcg ggtaagcagt tggaccttgt cggccaccat
2571601 gaacgacgag tagaagccga tgccgaactg accgatcagt tcctcggagg cggccgcgtt
2571661 cttggcctca cgcagctgtg cgcgcagctc ggcggtgccc gacttggcca gcgtgccaat
2571721 cagatccacc acctcctcgc gcgccatccc gatgccgttg tcacgaacgg taagagtcct
2571781 tgcagctttg tctgcgtcga tctcgatgtg cagatcggag gtgtcgacct ccaggtcctt
2571841 gttccgcagc gcctcaatcc gcagcttgtc tagcgcatcg gaggcattcg agatcaactc
2571901 ccgcagaaac gcgtccttat tggagtagac cgagtggacc atcaaatcca gcagttgccg
2571961 ggcctccgcc tgaaactcca actgctcgac atgggcgttc atgagattcc ttccgacgac
2572021 atagcgactc gaatttagcg agctgcgatc cggcgccgag ctgggggtgg cctggctagg
2572081 ccgtatcgcg agcaagctga tagaggtcgg gatcgtgtgc gcagacgatg agtagatccg
2572141 ggtcgtggcg tcgatggagt tcgacgattc gggcctggtt gtcgcgcagt tggttgcggt
2572201 tatacgacaa cagcttttcc tcggcccgca tcacgaaggg cacccggaac cggccatcga
2572261 gggtgccgcg atgatagaag gcgtcgccgc agtgcaaaac ccagcggtga ccggcatcga
2572321 cagctaccgc ggcgtgcccg cgggtgtgac cgggcatcgg caccagaacg acaccggtgc
2572381 cgatggaatc gaggggtttg gccgatgcga atccgcgcca gggttccccg tcgggaccgt
2572441 gctccaccag cttcgggccg tgggcccact gtccgcgtcg atatcgcagt cgctcgcgga
2572501 gcgaaggggc gtggatggca ccgcgggctt cggcggcggt gacgtggagg tgagcctcgg
2572561 ggaagtcggc gatcccgccg atgtggtcga agtcgaagtg ggtgagcaca atgtgtcgaa
2572621 cgtcggacgt gcggtagccg agctgttcga tctggcgggc cgcggtttcg gcctgcaaga
2572681 atgccggccg caggacatga cggaatagac ctacccggcc ggggtcaagg cagtcctgga
2572741 taccgaagcc ggtgtccacc agcaccaatc catcgtcggt ctcgacgagc agaacgtggc
2572801 ataacagagc gatgccaaat gcattcatgg tgccgcagtt gaggtggtgg accttcaccg
2572861 gcggtccctt cgcttcgggg gcgacaccta acatactggt cgtcaaccta ccgcgacacc
2572921 gctgggactt tgtgccattg ccggccactc ggggccgctg cggcctggaa aaattggtcg
2572981 ggcacgggcg gccgcgggtc gctaccatcc cactgtgaat gatttactga cccgccgact
2573041 gctcaccatg ggcgcggccg ccgcaatgct ggccgcggtg cttctgctta ctcccatcac
2573101 cgttcccgcc ggctaccccg gtgccgttgc accggccact gcagcctgcc ccgacgccga
2573161 agtggtgttc gcccgcggcc gcttcgaacc gcccgggatt ggcacggtcg gcaacgcatt
2573221 cgtcagcgcg ctgcgctcga aggtcaacaa gaatgtcggg gtctacgcgg tgaaataccc
2573281 cgccgacaat cagatcgatg tgggcgccaa cgacatgagc gcccacattc agagcatggc
2573341 caacagctgt ccgaataccc gcctggtgcc cggcggttac tcgctgggcg cggccgtcac
2573401 cgacgtggta ctcgcggtgc ccacccagat gtggggcttc accaatcccc tgcctcccgg
2573461 cagtgatgag cacatcgccg cggtcgcgct gttcggcaat ggcagtcagt gggtcggccc
2573521 catcaccaac ttcagccccg cctacaacga tcggaccatc gagttgtgtc acggcgacga
2573581 ccccgtctgc caccctgccg accccaacac ctgggaggcc aactggcccc agcacctcgc
2573641 cggggcctat gtctcgtcgg gcatggtcaa ccaggcggct gacttcgttg ccggaaagct
2573701 gcaatagcca cctagcccgt gcgcgagtct ttgcttcacg ctttcgctaa ccgaccaacg
2573761 cgcgcacgat ggaggggtcc gtggtcatat caagacaaga agggagtagg cgatgcacgc
2573821 aaaagtcggc gactacctcg tggtgaaggg cacaaccacg gaacggcatg atcaacatgc
2573881 tgagatcatc gaggtgcgct ccgcagacgg ctcgccgcca tacgtggtgc gttggctggt
2573941 aaacgggcac gagacaacgg tgtaccccgg gtcggacgcg gtcgtcgtca ccgccaccga
2574001 gcacgcggag gccgaaaagc gcgctgccgc gcgggccggg cacgcggcga catagccggt
2574061 gaaaagctct gctggcgatg tggggcctac aggtctcacg tgtcgagccg cagcacacgt
2574121 gtggcgttac gccatagcca gtcctccagg acttcccggg ggaccggcag cgcacgcatc
2574181 tcgtcgcaca attgcaggta agggcggttg atgagaaatc cgccggtacc gtaaacgatc
2574241 ttgttgcgga ttgttgtctg cccaaaccgc atcagcggct cccatccagc gcccggtgaa
2574301 gcgaagtact tgggacggtg cgcggccaat tccaggtaga cgttcgggtg tttccaggcg
2574361 atcaggcatg cctgcagcac ccacgggtag ccgccgtggc tcatcaggat cgttaactca
2574421 gggaagcggc aggcaacgtc gtcgatgtgg cggggatggc cgagatcgct gagccgtgtc
2574481 cgagtccaat cggcggaggt gtggatggaa acgggcacac caagctcgac gcatttggcg
2574541 tagcaaggga agtaggcggg gtcggatgcg ggccgtccaa tcatgaacgg acgcaagctc
2574601 aacccgcgga aaccgtgctc gaccacccag cgctcgaact cgtcgactgc cgagtcgccg
2574661 gccaggatgt cggcaccggc gaagggtagg aaccgatctg gatagcgggc cgcgacggcg
2574721 gccaccgagg cattgtggac aaaggtgaca ccacacgtgg accgttcatc gaatcccgtg
2574781 atcagactgc gggtaatccc ggcgtcgtcc agggagtcca gtatttggtc gtctgtcctg
2574841 cgtagcgact ccgcgtaggc accgaactgc tcggcgctga tcgtcgtctt ggtgaagacc
2574901 tcgaaatacg acagcagctc gacgggaaat ccttcccgaa gatcgtcaat gacctcggcg
2574961 gacggaacga acggtgccca catatcgatg accggcaccc gcggttcggg cgcggtcatg
2575021 gggtgctccg cgggccaacc ggaccgtgca ggaagtcatc gaatccggca tcgcgctcca
2575081 cggcgaatgc ctgctcgaac gtcgtggcgg ggcggccggt gcacgtcgcc tccttgacat
2575141 cgactcgctt cccggtgagg tcgcacagga cacaacggtc cagcgcgccg tcgtcggctt
2575201 cctcggtagc aatgtcgtgg ctcatcgctc ctccgttgac tgtgtcgacc agctgagcat
2575261 gcgctcttat gcgattacgc caagtcaact gaccccgccg acgcttcgca tacctagtgt
2575321 cggccagggc cacctggccc gcccggacct cccggcccgc ctggtccgcc cggacccccg
2575381 ggtccgcctg gtcggtttac ggcggggagc cagaacacgc attgattcaa gtcggggctc
2575441 cacacccagc cgggcgcgca atcatcgtcg gcccggctgt tcgccggctc gacaagtccg
2575501 gtcaccgcca acaccgtcaa caccgcagtg aacgcgcaaa gcgcgcagcg tcgtagaaaa
2575561 tgcctcatcg cagacctcac ggtttgtcgt ccggcgctgg acctaggtta tcgccacgac
2575621 cgccgcggcg gcagcacacg tggcgactca ccgcggccgt agaaccggtt gagcagcaag
2575681 ccactgcgcg ttggtaagag cggatccaag cgccggcaac ggatggtcgg cgagggcgct
2575741 gatcgggcaa cgatgcccag gccaggcggc cccagcgaac gccgcaccgg ctggaggaag
2575801 atagccccat gacccaaacg ctgcgcctta ccgcgctgga cgagatgttc atcaccgatg
2575861 acattgacat cgttccttcg gtgcagatcg aggcgcgggt gtccggtcgt ttcgacctcg
2575921 accggcttgc cgctgccctg cgcgccgccg tcgccaagca cgccctggct cgggcgcggc
2575981 ttggccgcgc cagcctaacc gcacggacgc tgtattggga ggtacccgac cgcgcggatc
2576041 acctcgccgt ggagatcacc gatgaacccg tcggtgaagt tcgcagtcgc ttttatgcgc
2576101 gggctcccga actgcaccga agcccggtct ttgccgtcgc ggtggtacgc gagaccgtgg
2576161 gcgaccgcct cctgctcaac ttccaccacg cggccttcga cggcatgggc gggctgcgtc
2576221 tgttgctctc actggcccgg gcctatgcgg gcgagcctga cgaggtcggt ggccctccga
2576281 tcgaggaagc ccgcaacctt aaaggcgtcg ccggctcccg cgacctgttc gacgtcctga
2576341 tccgcgcccg cggcctggca aaaccggcca tcgaccggaa gcggaccacc cgggtcgccc
2576401 cggatggcgg ctcgcccgac gggccgcgct tcgtgttcgc cccactcacc atcgagagcg
2576461 acgagatggc aaccgcggtt gctcgtcgac ccgagggggc gacggtgaac gacctggcga
2576521 tggccgcgct ggcgttgacg atcctgcagt ggaaccgcac acacgatgtc ccagccgccg
2576581 attccgtgtc ggtgaacatg ccggtgaact tccggccgac cgcgtggtcg accgaggtca
2576641 tctcgaactt tgccagctac ctggcgatcg tgctgcgggt cgacgaggtg accgatctcg
2576701 agaaggcgac cgccatcgtc gccgggatca ccggaccatt gaagcaatcc ggcgccgccg
2576761 ggtgggtcgt ggatctgctc gaagggggaa aggtgttgcc ggcgatgctc aagcgccaac
2576821 ttcagctgct tctccccttg gtcgaagatc ggttcgtcga aagcgtctgt ctgtccaacc
2576881 tgggccgcgt cgacgtcccc gctttcgggg gcgaggccgg ggacaccact gaggtgtggt
2576941 tcagtccgac ggcggccatg agcgtcatgc cgatcggggt tggcctcgtc ggcttcggag
2577001 gaacgctgcg cgccatgttc cgcggcgacg ggcgaaccat cggcggcgag gcgctgggcc
2577061 gcttcgccgc actgtatcgc gacacactgc tgacctgagg gcccggcatg accgacaacg
2577121 agtgcccggc cgacagccga cggcgccatg tcctgcggct cgccctgttc gccgggattt
2577181 tgctggggct gttctacctg gttgcggtgg cacgagtcat ccacgtcgac ggggtccgta
2577241 gcgcgatcgt ggtggcgacg ggtccgatcg cacccctggc gtacgttgtg gtgtcggccg
2577301 cactcggcgc gttgttcgtc ccgggcccga tcctcgccgc cggcagcggg gtgctgttcg
2577361 ggccgctact agacaccttt gtgaccctgc cagctttctc ggccggcgcg caggccggaa
2577421 tgacgcccag gcgctgctgg gtgtcgatcg cgcccatcgc ctcgatgcac agatcgaacg
2577481 gcgcggattg tgggcggtgg tcggtcagcg cttcgtcccc ggcatctcgg atgcgctggc
2577541 ctcgtacacc ttcggggcgt tcggagttcc gttgtggcag atggtcgttg ggtcgttcat
2577601 cgggtcggcg ccacgggtgt tcgtctacac cgcgctgggc gcgtcgatca ccaacctgtc
2577661 gtcgccgctg gtttactcgg cgatcgcggt gtggtgcgtg accgccatca tcggggcgtt
2577721 cgccgcgcgg cgttggtacc ggaagtggcg tgcgcgcccg cgccggcggt gcggcctggc
2577781 tcagctcacg accggtagtc agcaacgcca cacgagtcac cggacaccgg cgggcgtcgt
2577841 catgcccggt tcactgtccg agcaccgccg tctccgtcaa gaagcgccgg atcgcatcga
2577901 gcatcacccg cccatcgagt agttccgggt cgttgtgacc cacaccggga accaccacgt
2577961 atcgcttagg ctcggcggcc gctgcgacca gccgctcact aagcgtagcg gggacgatgt
2578021 cgtcgctgcc gcccgcgatg accagcaccg gcgcgtgtac agaggcgatg cgctcgatcg
2578081 acgggtagtg gtccagcagc aaccggcgca gcggcagcca cgggtagtgc accgcgccga
2578141 cctcggccag cgacgtgaac ggagatctca gcacgagtgc cgccggcggc cgttgcacgg
2578201 ccagcccgac cgccaccgcc gcgccgaggg attcgccgaa ataggcaatg cgcgcggggt
2578261 cgacgtcgga ctggccggac agccactcct gcgcggcccg agcgtcggcg gccaggccct
2578321 gctcagacgg ccgacccggg ttaccgccgt agccgcgata gtcaaacagc aacaccgaca
2578381 ggcccaggcc atgcagcgcg acagccagct ccgcacgcat cgaccggtcg ccggcgttgc
2578441 cattgcacac cagcaccgcg ggcccactac cgcccgaagt atgcgggaag taccagccac
2578501 ccaagcgcat tccatcttgt gtttcgacca cgacatcgcg gccggcgggc aaaacggagg
2578561 aagccgatgg caccggaccc gcagacggga agtagattag ccgacgctgc tgcgaccaga
2578621 tgaacataat cacgcccgat gccaccagcg cgacgatagc gaccaccggc aacgcgcgac
2578681 acctctttag cgacatctag ccccgcaccg gtgcgacgca tcgaaagcgg ggtccccgcg
2578741 accagtggat taccgaaacc accgttccaa acagaaaatc gacacgaaat tcaacgacgc
2578801 ggcgggccgg cgatggccac gagacaccca caaccagcaa ccgccccaat catcacgcca
2578861 accagctcag tacaccgccg tggcgcgaac acgtgcctga ccggtgtgtg ctgaacgagt
2578921 acgacccgtc cctacaaatt gcggtggcgc cgggtggcgc ccccgaacct ggcggcactt
2578981 gccggggagc aggtatgcac tgaccgtcca cgttctcgta gtagccgcta ggacaggcaa
2579041 acaccgaagt cggcgtcgac ggagaaatgg ccgggacgaa gccgaaacca actgccgccg
2579101 caacaacgcc gacggcaaac cgcctccgag cagacactgc tagccttcga tcatcacgct
2579161 tacgactccg cgtcccagca aagcgtaccg agtacatcgc cagccgggaa gggatatggt
2579221 cccgcgacta gcggatcagc agagtgcgca gttccagtgc tctggcaaac caacacgtat
2579281 tgctcgccga tccaacatat tcgttgaacc ttgagaaagg cttgcggcgc atcgcccagc
2579341 ccagcgccac tgccaccacg ggaggagaaa tccaaccgtc accacgacac cacggatagc
2579401 gaagatcaac aaatgccacc cacgttcggg cgcaccaagg aagccaccgt cgcgatactt
2579461 acctatcgtt gcatccgttc tggcgatatt tttcaactcg cattcatgcg ccccctccgc
2579521 aagagccggg agcggctaat ggtggcaccg ggctaccatc gtcaataaca cacgacaagg
2579581 taagcgtcgt accaacaaac ggcgctggta cccgcacttg atgccaatag ctgccgtctg
2579641 gatatctgat tccgtcacaa tatccccacc cggtaatccc accaaagcca ccgccagggc
2579701 aatatcccat cgcactattc ggcatgtgcg gatcttgtcc cggcggtggc gcgggttcgg
2579761 cgttggcaga aaccatagaa aattcaactg ccatagtcaa tgtaccgatt gcgatagcaa
2579821 tactattttt atacattttc tcaacacctg aattcattcg tgtggggaat gcagcctttt
2579881 ggcccccaca tgcccggtgt cccatcgctg gcgggccagt agggacttct tccacggccg
2579941 gaagatcatt gcgcgttggt tgtgcgagcg ggcggctgac ggcttcgcat aatggcgtgg
2580001 acgggctgtc atcgttgtcc ctcagcgcta caacaagtca gggaaactct tcacaggcgg
2580061 tgccgtcgtc gccgtggtcg aggccaagac ggtaacccgg ctcaccccat agagcggggc
2580121 cacccccgcg tcccgccttg cagttctggt agtaccggaa ccacgcgggt atcggcgttg
2580181 gggctgcatg agccacaggt ggcgccacat cgccgaccgc gatcacagct gcgaggaccg
2580241 gtggacgctg catgatgagc cctacgtgta gtaccagacg gctttggttg tgactggctg
2580301 gtcagtcgcg taaaccgtgg acctggctac tgctgaaagt accatgacgc ggggcaacga
2580361 aacagcagca acgtcgacag acagcggaac tgtcggctac cgccgataac gttgtgtcat
2580421 gcgtgcggac atgtccgtca cctcgatgct cgaccgagag gtctacgtat acgccgaggt
2580481 cgataagctg atcggcctcc ccgccggcac cgcgaagcgg tggatcaacg gctacgagcg
2580541 tggcggcaaa gatcacccgc cgatcctccg cgtcacgccg ggagctacgc cgtgggttac
2580601 gtggggcgag ttcgtcgaga ctcgcatgct tgctgaatac cgcgaccgcc ggaaagtgcc
2580661 aatagtgcgg cagcgcgcag cgattgaaga actgcgtgcg cggttcaatc tccgataccc
2580721 gctggcacat ctgcggccgt tcttgtcaac gcacgagcgg gatctgacga tgggcggcga
2580781 ggagattggt ctgccggatg cggaagtgac gatccgtact gggcaagcgt tgcttggtga
2580841 tgcccggtgg ctcgccagca tcgcgacacc cggtcgggat gaggttggcg aagccgtgat
2580901 cgtcgaactg cccgtcgaca aggcctttcc cgaaatcgtc atcaacccaa gccgatatag
2580961 cgggcagccc acgttcgttg ggcgtcgtgt gtcgccggtg acgatcgccc aaatggtaga
2581021 cggcggtgag gaacgcgagg acctggccgc cgactacggt ctcagcctga agcagattca
2581081 agacgcaatc gactacacca agaagtaccg gctggcccga ctggtggcgg cataaggccc
2581141 ggcgatgctc gaagtcgaca aagtcaccca tgttgtcgat gaaaacctgc ttcggcttgg
2581201 tgtggccttg tcgccgtcag aaaagacacg gcccggtttg gccgcccgcc cgtcgacgac
2581261 ctgctaccgc aaggcatcct cgacaccgac tggatcccca tcgtcggggg tcgggtgggt
2581321 ggtcatcagc aacgacaggc atctccggac gcggccagtg gaggccgagc tggcggtcgc
2581381 ccacaagctc aaagtcgtgc acttgcatgg ccgtgtgggc ggactagtcc gcgtgggcac
2581441 agctgacgcg gctggctgcg cggtggccgg ccattgagca ccaatatgag aaggcaccgg
2581501 aagggccttg gtggttgtcg gtgcggagga gcaggaccgc cgtaatggag ttcgcgcccg
2581561 gcgccgtcga caccatagcg tcggacaaca tggctgccca aaatgtccac gatacggctg
2581621 tgaagacctc gaggtgatgg ccgaaaggtg accacctcgc agtggtagga cgacagcgac
2581681 ccgatcgaag gcaatgccgc cgcatcgagc gcgactttgg gcatgacagg atttcgagta
2581741 agcgcatcaa cgtgtccgaa atgtggggcg ggcggggctc gaacccgcga ccaacggatt
2581801 atgagtccgc ggctctaacc aactgagcta ccgccccttg tgctaactag ctgcagatat
2581861 gttctccacc gcgactgaat cagggtcgga ataccgcagt gatgccgcag cactcttgat
2581921 ggcctgcaca agcaaacctg ccacgcccgc caggtcgtcg ctgagcaggt ggccatggcg
2581981 gtccaaggtc atggccgctg tggcgtgtcc gagaagcctc tgcacgactt tgacattagc
2582041 gcccgcactg atcgccagcg acgccgtggt gtgcctcagc ccgtgcggga ccaggtcggc
2582101 aatgccaacc gccttgcatc ccttgtcgaa ggctctgcgg tactcctcga taggtaggtg
2582161 cccgccgcgg tagcttggga acacgagggc attgggctcg gttggcagtt catcacgcag
2582221 gcgctccgat accggctcgg ggacaggcac gtgacgcacc cggttggtcg tcgtctcgac
2582281 aatcccggcg ccggtcacac agatgagcga atcgtcaact cccggtcccc acgttcttgc
2582341 gacgcagggc cgctgcctcg ccgaagcgca gtccgcagta gccgagaacc agggtcagcg
2582401 tcagtaccgc aacaatccgt ggtacgaatc cgttactcac ccactccccc gcgctcggtc
2582461 ttggcagctt ccgcctctac ccacgcatcc aggtcggcga tatcgcaaaa cgtgtgtcgg
2582521 ccaaggcgat agctgcgcgg actggtgccc agtaacgcca gtacctcagc gtcgactcag
2582581 gtaggccgcc gaggtattcg gctgcggcct tggtgcccag ccgaaccaca gatgtcgccg
2582641 tcatcgctct acttcctgtc gtcgctcaac gcgcttatgt cccaatccct ttggcagtcc
2582701 cagggccgac cgcaaaatcc tttccattga ccgcacagta accattagcc cgatggcatc
2582761 taacaaccga agaacgccga gaagtcgaca ccaagatccc gatgtttgcc gtagcaggaa
2582821 cggcggtcac actcgggctg attcgagcca gtcgtacatg tcgcgccgcg tccagcgccg
2582881 atcccgcccg ccgaggcgca cataatgggg tcccggtgcg tcaattccgc gctctcgctt
2582941 tgcagcccag ccgtgcaggg tcgacactgg cacaccggtg atctcccgca cctagatggt
2583001 ggtaagcatc tccgcgtggc tttcgttgtc ttccatcatg tgctttggcc accagtagcg
2583061 acgacatcac cataaatcga caccctccgt tgaattgcgc cgtaaatcgc cacgacgaaa
2583121 gccgacggtc tccgctgcgc cggggcctac tcgccaacgg cctaagagag aggcaagctg
2583181 gggcattatt cgaacgttac gaaagccagt tcgattcatt cggatatatc gagaaggtgc
2583241 ggtatcgggg ctcagggtat cgagtcgaag acgtttatgc ccgagcggac agtggaccta
2583301 gcgccggtgc tgagcttcct gtcggcccat gagcggcggc gcggccgcac gctggccccc
2583361 agctacgcgc tggtgggcgc cacgagcacg accgcgtcga gctgccgcgc gaggttcatc
2583421 aggcgctaag gcaggtggtg gctgcgctgc acgccggcaa ggcggtgacc atcgcgccgc
2583481 agagcatgac gctgaccacc cagcaggccg ccgaccttct cggggtgagt cgtccgaccg
2583541 tggtgcgtct gatcaagagc ggcgagctgg ccgccgagcg catcgggaat cgccaccggc
2583601 tcgtgctcga cgacgtgttg gcctaccggg aggcccgccg gcagcgccag tacgacgcgc
2583661 ttgccgagag cgcaatggac atcgacgccg acgaggatcc cgaggtgatt tgcgagcagt
2583721 tgcgtgaggc gcggcgtgtt gtcgccgcgc gccgtagaac tgagcggcgg cgcgcctgag
2583781 accatcgctg catgctcgac acgtcgctgc tgtggtcaag ccggcagcgc gactttctgt
2583841 tgtcgttggc gacgtcgccg cgaactacga cgggcgggtg gtggtggcgc cgacaggcca
2583901 ggccgtcgac gtcgcggtac gtgaaggcgc cggcgatgtc ggctacagcg tcgagcgaga
2583961 gaatcttccg gccgacgatc cggtgcgcaa cggcaaccgc tggcgggtca tcgcggtcga
2584021 caccgaacac caccggatcg ccgcccgccg cctgggcgac ggcgcacgcg ccgccttcag
2584081 cggcgactac ctgcacgagc acatcaccca cggatatgcc atcaccgtcc acgccagcca
2584141 gggcaccacg gctcactcca cccacgctgt gctgggcgac aacaccagcc gagcaacgct
2584201 gtacgtggca atgacgccgg cacgcgagtc gaacaccgct tacctatgcg agcgaacggc
2584261 gggcgaaggc gcgcgagtgg atctcgccgg atgggacctt tgggtgagtg ggaaagctga
2584321 ggcaatgagt gacgagaaat ccgcatcgcc agtttggtgc cgtgtcggag ctcggtgcga
2584381 tcatcgggga aagcgttcct gctggtgagg gcagaattgt tgtgcacgtc gtgcgctata
2584441 ccgtggtgac gactcgccga agcatggact aaggaggtag ctgcgatgat gaaggagatc
2584501 gagctccatc tggttgacgc tgccgccccc agcggcgaga ttgcgatcaa ggacctagcc
2584561 gccctcgcga ctgctctgca ggaattgacg actcgaatca gccgcgaccc aatcaacacg
2584621 cccgggcctg gtcgcacaaa acagtttatg gaagagctct cgcaactggc cagcgccccc
2584681 gggccagaca tcgacggcgg gatcgaccta actgacgatg aattccaggc gtttcttcag
2584741 gcggcgcgtt cgtgaatcaa gtagcggcga cggtggtcga caccgacgtc ttcagcctga
2584801 tctaagacac cgactcgcgt gacctcggct gccgcgccca gacgccgtgg cacttctgcc
2584861 gttcggtcgc cgcctggctg gccggagtca tcacagcacg ctccaatagc gcctcatgga
2584921 atcagccggc gccctcgaat cgagccttac ccgcccgaaa cgacacgcct cgacggtacc
2584981 tggcgcgctg acctggccct acatcagtca acgtatacga accacagcgt cgcggagctg
2585041 ccagaccgcc gtcaaccgaa caccgtctga ccgtcaagcc caatgcgata ccgttcggtg
2585101 ccctgctgca ccctgggcgc atcagcaccc aacgacactg caaccttgtt gctggcgttg
2585161 cgcatgatgt caaaggtcag ctcgacggcc tcgtcgtccg agaaccggga gcgcacctcg
2585221 acggcaacgt cgacggcgag gtgcgcaggg gtccaaatta acgcatctgc atacctcagg
2585281 gcggcttttg cgcgaacgtc gagcaagacc gaggtatcga aacgctcgat ctcgccatac
2585341 aacgtctccg aaccgcccgc atcaagcgcg gagacctccc gcaacgactt gcacacccgg
2585401 caattgtgct gcgcagctcc acgcagccgc accagctcag aggtgaccgg gtccagtgcc
2585461 cgcatccggg ccaccgccgg cagaaatccg ttgaacaccg cagcggacag atcggtgttg
2585521 tgatcccagg agatcggccc ggttacccag cccagatact ccttgccgac gcccaatgct
2585581 tccaacccgg cgcgcacccg cggcacaaag tcggcgatgt acatcgccac aaccgcaccg
2585641 aaagcgtctt cccccaaatg cgtccacagc agggatcgct gctcgccggt gatcgctgag
2585701 acatcgacgc tgaactgctc ggcgaactcg gcaacgacgg cctcggccgg cgactccggc
2585761 tcgttcaccg caacctcaca cggcaacgac ggtagcgaca gcgcccgcgc gcacacctgc
2585821 ctcaccagcc ccgcaatccg gccgtcgccc ggcgatagcg ccaccaaccg acacagatcg
2585881 tcacgaaccg aaaccggggc cggcaccctt cacacgctac tgcgcctggc tcaccgagga
2585941 catgtggaag tcgggaatcc gcagcggcgg catcgcggta cgggtaaccc aatctgacca
2586001 ttcgcgcggc agtgtcggct cgctgacacc tgcttcggtg gcccgtcgca gcaggtccag
2586061 tgggctttcg ttaaaccgga agttgttgac cgccgcgctg acctcgccgt cttcgaccag
2586121 gtagacaccg tcgcgggtca gcccggtgag cagcagcgtg gtcgggtcga cctcgcggat
2586181 gtaccacagc gtggtcagca acagtccgcg ctcggtgccc gcgatcatgt cggcgagatc
2586241 ggccgacccg ccggtcatga tcaagttgtc ggcggcgacc gcaactgggg cgtcgaattt
2586301 ggcggcagtg gcccgtggat acgccagcgc attgatcaca ccgctgcgga tccagtccac
2586361 ctggctgatt tccatgccgt tgtcgaacac cgattgcgtc tccgaggagt tgctcaccgc
2586421 cacaaacggc gtacacgcca gacccggcgc agccggatcg gtgaacaacg tcagcggcag
2586481 ctcggtcaac cgctctccca cccgggttcc accgccagga gccgagaaag cggttcggcc
2586541 ctcctgcgcg ccgcgcccgg ccatcgacca acccaggtag atcatcatgt cggccaccgt
2586601 cgacggaggc atgatggtct ggtagcgccc ggccggcagc tcgacggtgc gttgcgccca
2586661 ccgcagccgc gtcgacagcc gctcgagcat cagatcgatg ggcacctcga cgaaatcggg
2586721 tgtgccgatc cccacccaag cgctggcgtc gccgcgtttg gcgttgatct cgatcgcccc
2586781 ggtgggctgg gtgtagcggc ggcgcagacc cgtcgacgat gccagaaacg tcgtggacac
2586841 actgcggtgc gcgtagccgt acaagcggtc ggccccgcgg aagcccctgc tcagtgagcc
2586901 ggcgataccg gtgaaaaccc ctgccccggt gcccggaacc ggggcatccc agtcgtcggg
2586961 ctctccggta tcggcaagca gcggcgcggc atcaccggcc tccggcgcgg agcgggccgc
2587021 gtcctgggag gacaccacca gaccgggcag caccgacggg tccacttcgg cggagaccac
2587081 ggagccgacg aaggcgctat ctccccgtcg gacgatcgaa atcacggtga cgtttcggct
2587141 gtgggaaacg ccgttggtgg tcatcgaatt gcccgcccaa cgcagtgtcg cctcgacctt
2587201 ttcggtgacc agcaccatgg tctcgtccgc ccggccagac ctggccgctt cctttaaaac
2587261 gatgttgacg gcgtgctgcg gctcgatcat cgaccacctt cagtacgagt attgagcaca
2587321 ttgacgcccc ggaacaacgc cgacggacag ccatggctga ccgcggcaac ctggccgggc
2587381 tgggccttgc cgcagttgat ggctccgccc attcgccagg tcgacggccc gcccacggct
2587441 tccatggcat tccagaaatc ggtggtgctc gattgatagg cgacatcacg cagctgcccg
2587501 tacagctggc cacctcggat gcggaagaaa cgctggccgg tgaactgaaa gttgtagcgc
2587561 tgcatgtcga tcgaccatga cttgtcgccg acaatataga tcccgtcgtc gacccggccg
2587621 atcaggtccg cggtgctgag gtcttcgatg cccggctgca gcgatatgtt ggccatccgc
2587681 tggatcggca cgtgatgtgg cgagtcggca tacgagcagc cgttggaacg tggctccccc
2587741 aaccgtgggg cgaacgcccg gtcgagctgg taaccaacga acaccccgtc acgcactaga
2587801 tcccagctct gcgcggccac tccctcgtcg tcgtaaccga cggtggccaa gccgaattcg
2587861 gcggtacggt cggcggtcac gttcatcacc ggcgagccgt agcgcagggt gccgagtttg
2587921 tctggggtgg caaacgatgt cccggcatag gcagcctcgt agccgatggc acggtcgtat
2587981 tcggttgcgt ggccgatgga ttcgtgaata gtcagccata ggttagtggg gtcgatcacc
2588041 aggtcggtgg gccccggcat cacgctaggc gctcggacct tctcggccaa cagcgatggc
2588101 agctgcgcga gctcgtcggt ccagttccag atctcgtcgc cggccaccac ttcccagccc
2588161 cgggcggtcg gcggagccaa cgtccgcatc gattcgaagt tgcccgccgc ggaatcaaca
2588221 gcaaccgcat ccaggcacgg cagcagccgc acccgctgtt gggtaatcga tgacccgaag
2588281 gtgtcggcgt agaaggtctg ctccttgacg gcgttcaagc tggccgatac gtggtcgatg
2588341 ccgtcggcgt ccagtaaccg cccggagtag tcgcgcagca cggcgatctt ctcggaggcg
2588401 ggaacgccga acggatcgat ccggtagttc gagacccact ccgcgtcggt gtatacgggc
2588461 tcgggcgcca atctgacccg ctcggtgttc agcgccgcca gcacggtagc cacgtgtacc
2588521 gcatggcgag cggtcgcggc cgcgacgtcg ggtgccaact cagcatggga ggcgaatccc
2588581 cacgtgcccg cgacgattac ccggacggcc aggccgagct cacggctgat caccgcggtc
2588641 tccagctcac cgtcacgcag ttggatgatc tcggtgctaa tgcggtgaac ccgcaggtcg
2588701 gcgtggctgg ccccggccgt ggcggccgcc gacaatgcgg cgtcggccaa ctgctggcgc
2588761 ggcaggtcca ggaagtcttc atcgatcccc cggttcggtg tcacgactcc accgtaacga
2588821 ccagctttaa tacacccatg cgcgacgcgc cacgtcggag gacggcactg gcatatgccc
2588881 tgctggcgcc cagcctggtg ggcgtggtcg ccttcttgtt gctgcccatc ctggtggtgg
2588941 tatggctgag cctgcaccgg tgggacttgc tgggcccact gcgctacgtc ggcctgacca
2589001 actggcggtc ggtgctgacc gattccggct tcgcagactc attggtggtc accgccgtct
2589061 tcgtggcgat cgtggtcccg gcgcagacag tactgggact gctggccgcg tccctgctgg
2589121 cccggcgact gccgggcacc ggcctgttcc gcacgctgta cgtgctgccc tggatctgtg
2589181 caccgctggc gatcgcggtg atgtggcgct ggattgtggc gcccaccgac ggcgcgatca
2589241 gcactgtgct cggacaccgc atcgaatggc tcaccgatcc aggcctcgcg cttcctgtgg
2589301 tttcggccgt cgtggtgtgg accaacgtcg gatatgtctc gttgttcttc ctagccggat
2589361 taatggcgat tccgcaggac attcacaacg ccgcacgcac cgacggcgcc agtgcctggc
2589421 agcgcttctg gcgcatcacc ctgcccatgt tgcggcccac catgttcttc gtcctggtta
2589481 ccggaatcat cagcgccgca caggttttcg acaccgtcta cgcgctgact ggcggtgggc
2589541 cgcagggcag caccgacctg gtggcccacc gcatctacgc cgaggcgttt ggggccgcgg
2589601 caatcgggcg ggcatcggtg atggcggtgg tgctgttcgt catcctggtc ggtgccaccg
2589661 tggtgcagca tctgtatttc cggcggcgga tcagctatga gctcacctag tcgcgtctcc
2589721 aacactgcgg tctacgcggt gctgacgatc ggcgcggtaa tcacgctgtc ccccttcttg
2589781 cttggcctgt tgacctcgtt cacttccgca caccagttcg cgacgggtac tccgctgcag
2589841 ttgccgcgac cgcccacgct ggccaactac gccgatatcg ccgatgccgg atttcgccgc
2589901 gcggcggtgg tgaccgcgtt gatgacggcg gtgatcctgc tgggccagct gacattttcg
2589961 gtgctggccg cctacgcgtt cgcgcggttg caatttcggg gacgtgatgc gttgttctgg
2590021 gtctacgtcg caaccttgat ggtgccgggg acggtgaccg tggtgccgct gtatctgatg
2590081 atggcccagc taggcctgcg caacacgttc tgggcgttgg tgctcccgtt tatgttcggt
2590141 tcgccgtacg cgattttcct gctacgcgag cactttcgcc tcatcccaga tgacttgatc
2590201 aatgccgcgc gcctcgacgg tgccaacact ttggacgtga tcgtgcatgt ggtgatccca
2590261 agcagccggc cggtcctggc cgccttggcg atgatcaccg tggtctcgca gtggaacaac
2590321 ttcatgtggc cgttggtgat caccagcggc cacaaatggc gtgtcctaac ggtggcgacg
2590381 gctgacctgc agtcgcggtt caacgaccag tggacgctgg tgatggcggc gaccacggtg
2590441 gcaatcgtgc cgctgattgc gctcttcgtg accttccagc ggcacatcgt cgcatcgatt
2590501 gtggtctcgg ggctcaagtg acccggcccc gccagtccac gctggtcgcc accgcccttg
2590561 tgctggtggc gatcctgctg ggtgtgacgg cggtgctatt ggggctctcc gccgaaccgc
2590621 gtggcggaaa gatcgtcgta acggtgcgac tctgggacga gccgattgct gcggcgtatc
2590681 gacagtcgtt tgcggcattc acccgcagcc atcccgatat cgaggtgcgc accaatctgg
2590741 tggcctattc gacctacttc gaaaccctgc gcaccgacgt ggctggcggc agcgcggacg
2590801 acatcttctg gctatccaac gcctacttcg ccgcctacgc tgacagtggc cggctaatga
2590861 agattcagac cgatgccgcc gactgggagc cggcggtggt tgaccagttc actcggtccg
2590921 gcgtcttgtg gggtgtgccg caactgacgg acgccggaat tgccgtgttc tacaacgccg
2590981 atctgctggc tgccgccggt gtcgacccca cgcaggtgga caacttgcga tggagtcgcg
2591041 gcgatgacga caccttgcgc ccgatgctgg ctaggctcac cgtcgacgcc gatggacgca
2591101 ccgccaacac gccaggattc gatgctcggc gggtccgcca gtggggatac aacgccgcca
2591161 acgatcctca ggccatctac cttaactaca tcggctcggc cggcggtgtg ttccagcgcg
2591221 acggcaagtt cgcgttcgat aaccccggcg ccatcgaagc cttccgctat ctggtcggcc
2591281 tgatcaacga cgaccacgtc gcaccgccgg cctcggacac caacgacaac ggcgatttct
2591341 cccgtaacca gtttctggct ggcaagatgg cgctattcca gtccggcacc tacagtttgg
2591401 cgccggtagc ccgtgacgcc ctcttccact ggggtgtggc gatgcttccc gccggccccg
2591461 caggccgggt aagcgtcacc aatggtattg ctgcagctgg taattcggcg tccaaacatc
2591521 cggatgcggt gcgtcaggtg ctggcctgga tgggcagcac ggagggcaac tcctacctgg
2591581 gccgccacgg tgcggccatc cccgcggtgt tgtctgcgca accggtctac ttcgactact
2591641 ggtctgctag gggcgtcgat gtcacgccgt tcttcgcggt gttgaacggt ccgcgcattg
2591701 cggcccccgg cggcgccggc ttcgccgccg gacagcaggc cctcgaaccc tacttcgacg
2591761 aaatgttcct cggccgtggc gatgtcacga caaccctgag gcaggcacag gcggcggcca
2591821 atgctgccac acagcgctag ttgcgatcta gcccggtagt actagcacgg ggaccgggct
2591881 gtagcgaatg atcttgccac tccaggagcc gaggaatact ctcgcgacat caccgaacgg
2591941 cgaggtgccc aaggccagga tctccccgtc ctgccagtcc gcagcgtcca gcgcctgcgc
2592001 ccagccgttc ccggtgacca cttgcagcac aacgtcttca ctcacgacgc cgttaattct
2592061 tagtttttcc aacagttctc gcgcttgcgc cgcccatgcc tccagaaccg aagcctcggc
2592121 atgcagcccc acttcgggcg gatacatggt ccggccgcgg accgcgaatg tgatcacccg
2592181 catcggcacg ccataccggc tggccaggtg gccgcatcgc ctcaccacgt cgaccgaacc
2592241 cgacgtcgcg gagtagccgc agctgagccg tgtcaaccgg tcggtgtagc aacggtagcg
2592301 gcggggggtg atcgccaccg gtaccggcga cgaatgcagc agccggtcgg cggtcgagcc
2592361 gatcaacacc cgcgcgcgcc gcccgctggg aaacgacccc agcaccagca cctcggcttc
2592421 gagttcctcg acgacgtcga gcagaccagc cgacaccgat cggtgtgcgc ggtggtggta
2592481 gctgacctcg atcccgtcgg ccagtctgcg caggtagcgc tgggcctctc gcgcggaggc
2592541 ggcagccagc tgctcagacc agagctcgta ctcggcgtcg acgcgggcga gcgacggtgt
2592601 cggccagtgc ctgcgcacga tggtggccac tgtgagcgac gtcttgtgca tccgcgcgac
2592661 gcggacggct agatgtaatg cggacggacc gaccttgcca gccaaatacc cgacgacgat
2592721 ggtcacggca cttcctcgtt gagcgcactg tggtgccgac cccacatcag gtaaaagatc
2592781 actgccaccg ccacccatcc gctgaacgcc agccaggtgt accagtgcaa gctggccagg
2592841 atatacccgc aggccagcac cgaaagaaca ggcgtcacag ggtaaccggg taccttgaac
2592901 cctcggggta agtcgggctc gcgcacccgt agaacgatca cacccacagc caccacgctg
2592961 aacgcggtga gcgtgccgat ggacaccatg tccgccaagc tatccagcgg tatgaaggcg
2593021 gccagcgtcg atgcgaagat cgcgacgatc accgtgttgt gcaccggcgt catggtgcgc
2593081 ggattcacct tcgcgaaccg cgccggcagc agcccgtcgc gccccatcgc gaacaggatc
2593141 cgggtctggc cgtacatggt gaccagcgtg acggtgaaaa tcgagaccac cgcaccggcg
2593201 gccagaatcg tgctggccca ttcgccatgc gtgacgttgt ccaagatgat ggccagcccg
2593261 gcggtttcct gctctgcgaa gtcctgccac ggttgggtgc ccagcgcggc cagtgcgacc
2593321 agcacgtaga caccggtgac gaccaccagc gctgcgatca gcgcacgcgg catggtcttc
2593381 tgcgggtcct tcacctcgtc gccggcggtc gacaccgcgt caaggccgat gtatgagaag
2593441 aagatcgtgc ccgccgcgga gccgatgccg gcgacgccga atgggacgaa atccttgagg
2593501 tggtcggcgc tgtacgcgct gaacgcgatg atcatgaaca tgcccagcac gccgagcttg
2593561 atcagcacca tgatcgcgtt gaccctcgcc gactcgctgg cccctcgaat caacagcagc
2593621 gcgcatagcc cgatcaggat gacggcgggc aggttcaccc aaccgggatg ggtgtcccac
2593681 ggcgccgccg acaatacgtg cggcatctga aatccgaaca gattactcag cagcttgttc
2593741 acgtagccac tccagccgac cgcgaccgct gcggtggcta ccccgtattc cagcagtagg
2593801 caggccgcca ccaccatcgc gaccgcctcg cccagcgtcg tgtacgcgta ggagtacgcc
2593861 gacccggaaa tcggcacggc ggaagccagt tccgcgtagc agatagccgc gagcccagcg
2593921 gcgatgccgg cgatgatgaa cgaaacaatc acgcccgggc cggcctctgg aactgcctgg
2593981 gcaagcacga aaaagatgcc ggtacctatc gtcgcgccaa ccccgaacat ggtcagctgg
2594041 aaggtgccga aactccgctt gaggttcccc gatgccccgg atgcgaccgg ggcgccgctc
2594101 accgggcggc gccgcagcat cagttctcga aggctcatcg acgttgtcgg caattatgaa
2594161 cccgcctccc atagcgcgtc ggcgaaccgg cgaaccgcgc agtcgatctc ctgcgcggtg
2594221 atcactaacg gcggcgcgaa ccgcagggcg gcgccgtagg tgtcttttaa cagcacaccg
2594281 cgatcggcca accgcatgct catgtctgtg ccaatggcaa gcgcccgttc gatgtcgacg
2594341 tcagcccacc atccgaggcc gcgcagggcc accgcaccat cgccgatcag gtccgccagg
2594401 cgctgatgca gatgcgcacc caatttagcg gagcgagctt gacattctcc ccagacgacc
2594461 atggaaacca cgggggtacc gatcgcggcg gccaacggat tgccgccgaa cgtcgacccg
2594521 tgttcgccgg gatgcaccac gccgaagatt tcgcggtccg cgaccatcgc cgacaacgga
2594581 accgcaccgc caccaagtgt cttgccgagc aggtaaatgt ctggcagcac acccccgtgg
2594641 tcgcaggcga acgggtaacc cgtacaggcc agccccgatt ggatttcgtc ggcgatcatc
2594701 agcacgttgt gctcgacgca gccggcaggt agtcgtcggc cgggacgatg atgcccgcct
2594761 ggccgggaat cggctcgagc aggtcagcga cggtgttgtc gtcgattgtc tgcgccggtg
2594821 ccgcagcatc gccaaacggt accgagcgga gtcccggggt agaaggttcg acgccgctgc
2594881 ccgcagccgg gtccgacgag aagctgacga cactgctggt gtggccatga aagttgttgt
2594941 ttgccaaaat gatatcgtgc cggcccgcgg ggaggccgtt gacgtcggct ccccacttgc
2595001 gggcgaccct aagaccgctc tccaccgctt cagcatcaga gttcattggc aacaccacgt
2595061 ctttgccgca cagctgggca agcgcggcgc ccaacggccc gagtcggtcg gcatgcaagg
2595121 cccgattcag cagggtgacg gtgtcgactt gggcatgagc cgtggcggtg ctcgcggggt
2595181 tgcgatggcc aaggttgacc gccgagtacg cagccagcca gtccaggtag cgcaggccgt
2595241 cgatatcggc gatccacgca ccctcagcgc tggccgccac cacaggcagc ggcgaataat
2595301 tgtgcgctgc atgcctttcg accagtgcca tagtggcctg agtggcatcc gcgagatttg
2595361 tcatgggtgt atctccagcg tgcagcactt gacggaaccg ccgcccttga gcagctcgga
2595421 cagatcgaca ccgaccggct cgaagccggc tgcgcgtaac tgcgccgcaa aacccatggc
2595481 cgcgaccgga agcactacgt tcagaccgtc agagacggcg ttgagtccga acacgaacgc
2595541 gtcggcactg ccgaccacaa tcgcgtcggg gaacagcgcc gacaactgtt cctgcgctgc
2595601 cgtactgaac gccggcgggt agtaggcgat cgtgtggtcg tcgagcacgg ccagcgcggt
2595661 gtccaggtga tagaaccgtg ggtcgaccaa ctcgagggag accaccggca gaccaagcac
2595721 cgcggcgatt tcggcgtgtg cgcgctggtc tgtgcgaaag ccgtagcccg ccaacaccct
2595781 ttcgccaacc atcagcaggt cgccctgtcc ctcgttgacg tggcgggtgg tcaccgggcg
2595841 atatccgacc gaggacatcc agctggcata ggctctagac tcaccagctc gttcggggaa
2595901 ccggaaccgg gcgaccacgg cgatgtcgtg cgcgatgaac ccaccgttgg cggtgtacac
2595961 catgtccggt aacccggaaa tgggctcgat cagatccacg ctgtggccta gccgaagata
2596021 ggtctggtgg aggtgctccc actgtgcttg cgcgacttgg acgtcgactg gcgcggtgac
2596081 gtccatccag gggttgatcg cgtatgcgac ggcaaagaag gccggcgggg tcattgcata
2596141 ccgccgcgtc cggggggtgc ggcgtgcagg tgaccctaga cgggcagcag cgacgtagga
2596201 atccgtcata aaccaacgat atttggctct gatttcacaa tcaaacgatg gtcgttgcgt
2596261 attttccatt gatacattgc gttaacctcg aatctgtggt gattcgttgc gtgcttagaa
2596321 cggaggaggg ccgatggacc gcctggatga caccgacgaa cgcatcctcg ccgagctggc
2596381 cgagcatgca cgggccacct tcgccgagat cggtcacaag gtgagtttgt ccgctccggc
2596441 ggtgaagcgc cgcgtcgacc ggatgctcga gagcggcgtc atcaagggct tcaccacggt
2596501 ggtcgaccgc aacgcgctcg gctggaacac cgaggcttac gtgcagatct tctgccacgg
2596561 caggattgcg cctgatcagc tgcgtgccgc ctgggtgaat atccccgagg tggtcagcgc
2596621 ggcaacggtg actggcacgt ccgacgcgat cctgcacgtg ctcgctcatg acatgcggca
2596681 tctggaggcc gccctcgagc gcatccggtc cagcgctgac gtcgaacgca gcgaaagcac
2596741 cgtcgtgctg tcaaacctca tcgaccgcat gccgccctag tgttccgcgc caatgctaga
2596801 aaaggcctgc tgagctacgt agacgcagca tgagcaggtc ctcgcgccgc caacccgcga
2596861 aacggcgcgt ctgtacaccg acacgccgtt agggcgcgcg cccacgccca gctatcgccc
2596921 aagctcacca tcgcgttggg cggcggcggt ggcggccaac atcggggcta tagcggctgg
2596981 ccggtccgcg cgccgcccgc gccgccacct aggagtgcaa tatcaggctc tctatcgcca
2597041 ccgctgtccc gctggccatg gcagtgatcg caagcgtcac ccagtcggca agtttgggtc
2597101 gcccaggatg cgctgacagc tggccggtgc cgccacgggc ggtgatcgcg tcgcccatct
2597161 cgtcggcacg gcgcagggtc accgtgatgg cagcggcaag caggtcgatc agctcgcgcg
2597221 catgccgctg gcgccgagcc ttgcggcttg gcggcatccg cttgggccgc agccggcgcg
2597281 cggcgtagag cacctggaat tcgtcgatca acatcgggaa ggcgcgcagc gcgagcgcca
2597341 acgccaccgc ccattcgtcg accgggatcc gcaacacccg aaacggccga cccaaagtgg
2597401 ctaccgcagg gctgatttcg gcaacattgg tggtccagga caccatcgcc cccagcgcca
2597461 ggagcacaac cgacagcgcg gtgatccgca ggaagtgcag tgcgccgccc aatccgagct
2597521 gcactccgcc cacggcgacc actggagtgc caccggctag cgcagcggtc agaaagccga
2597581 tcgcgaggac gatccacagc cagcgaggta ccgacggcag cgcgccgcgc ggaatgtgcg
2597641 cgattcgggc cgcggccagc accaaagccg ccatcatccc gatcgtcacc catcccgggt
2597701 agaacgtcag caacaccgaa atgccgaaaa ccaccaataa tttggtgccg gcccacaggt
2597761 cgtggatgac cgagctaccc ggcaccggaa tcaacagcac aatcggacgt gacgggcgac
2597821 gagtcccgtt gcgtgccggg gccgaagttg tggtcatgac attccccccg cctccgacgc
2597881 cgccgccgat tccagcacac cgtcgcgcag atgcagggta cgcgggcaaa gctcctccat
2597941 ccccgcgaag tcgtgcgaaa ctacgaccac cgtcaggccg cgcgcccgac gcaagtcttc
2598001 cagcagccgc agcaggccgc gctggctggc cgcgtccaac cccgccaacg gctcatcgag
2598061 gatcaacgcc cggggtgcac gcgcaagcag cccggccagc accacccgac gcatctggcc
2598121 cccgctgagc tggtcgattc gtcgcgcgcc cagcgcgggg tccaacccaa cgacagtcag
2598181 cgccgcagcc acccggtcct gctcgctagc cgaaaaacct gctgcggaag caacttccag
2598241 gtctacacgg ctgcgcatca gctgcagccg ggccgcctga aaagacaacg ccaccgcgcc
2598301 gacctgctcg tgggtgggcc gaccgtcaag taggcaggct ccggtcgtgg ggatcgtcag
2598361 cccggccatg atccacgcca gcgtcgactt ccccgagcca ttgccgccgt ggatcagcac
2598421 cccgtctccc tgctcaacaa cgaagttgat atcgcgcaac gcggtctttg cccacggggt
2598481 gccgctagcg tattcgtggc cgacgcccac cagttcgagc gccggcgcgt gctggggctg
2598541 atccaccccg atgaccgggg ccggcatcgc ggcggtgtgg accatatcgg tgttatccgg
2598601 cgaatcgctc aggctgagcg tgcggtcggc ggaatcggct tcgttgtcgt agtgcgtgat
2598661 gtgcaccaag gcggtccggt gccgctgcgt cagacccgac agcacggcca gcaaagcgtc
2598721 cctgccctgc tggtcaacca tggtggtgac ctcgtcggcg atgagcatcg ccggctcccg
2598781 ggccagcgct gccgccagcg ccaggcgctg cagctcacca ccggacaggc ttccggtgtc
2598841 gcgttcggca agcgcttcca agccgacctc gctcagcaac cggccaacgt cagcggtggt
2598901 acccagcggc agcccccaca ccacgtcgtc ggcaacccgg gtgcccagga cctggctttc
2598961 cggatgctgc aagacgacag cggtgccgcc cagctttccc aaacccaccg tgcccggacg
2599021 atccacggtg cccgacgtcg gtgcccggcc ggccagtatc agcatcaagg tggtcttccc
2599081 tgatccgttg gccccgatga tcgctaggtg ctcgccggcc cggacgtcga ggctgacctc
2599141 ccgcagcgca tcttggccgg cgcgggggta acggaagcgg accttgtcca accgcaccgg
2599201 caccggcccg atcagagcgt ccacgtcatc tcctggcggt gggtcaagtt tgtgtacatc
2599261 ggggattccg cgcatccgct ccagcaggcg cgacaacgcc caccacccaa tcagcgacac
2599321 gatcatgatc ccaatgttga aatagcccag cagcacccac ggccagtact gcagtccctc
2599381 ggcgaaatac cgcttgacgt cggcggctgc cccctgcatg tgcatccggg ccaaggtggc
2599441 ggcgataccg tccacgtttg cggtcatgac cttgaaaatc agatgccgca gtcggaccat
2599501 ggcggccaac atcccgacca tcgccgcgcc gaacacgaat ccgccgatca gcgacgagac
2599561 gaccaccgtc ggggtgcccc ggcccctgcg tttgacgatt ccggtcagcc caccgatgta
2599621 ggcactgtgg accaccccca tgaaaccgcc cagccccgcg atcaggaagg cgatcatccc
2599681 ggccgcaacc gtcgcggccg ccagcacgcg gagacggtag cggtaggcca gcaggccggt
2599741 gggcacggtg cccaacagcg ccagaccggc cgcgaacgga acgacgacgg agatgatcgc
2599801 ggtcaccgcg cacagcgccg ccatcaccga cgcctgcgcc aattcactcg gccgcagcgg
2599861 cccgccccga tgttgcgcgg ggcaagggcc gagcggggtc acttcaccga ttctgccagg
2599921 ctcaggcccg cacacggcgc agcacatcga ttagcctcgc atagcaaagc tatgcaacga
2599981 tggggggatg agtccctccc ccgccgccgc caaccgcagc gaggtcggcg ggccactacc
2600041 gggcctggga gcggatctgt tggcagtggt cgcgcggctc aaccgcctag ccacgcagcg
2600101 catccagatg ccactgcccg cggctcaagc cagactgctg gccaccatcg aagcccaggg
2600161 ggaagcccgg atcggcgact tggccgccgt cgatcactgc tcgcaaccaa cgatgaccac
2600221 gcaggtacga cgactcgagg acgctggact ggttacccga accgccgacc cgggagacgc
2600281 ccgggcggtc cgcatccgca tcacgccgga aggcatccgc acgttgaccg cggtgcgggc
2600341 agaccgcgcg gctgcgatcg agcctcagct ggccctgctc ccaccggcgg accgccgggt
2600401 gttggcggat gcggtagacg tgttgcgccg gctgctcgac catgccgcca ccacgccggg
2600461 ccgggcgacg cggcaatagg catcgagatg tcgaacgccg cgccgttggc ggtgtgggtc
2600521 ggatcgatgc gcccgaaaac gcaaagggaa tcgcttggcg gctcctgctg ctggagttgt
2600581 ccggaccatc ccgactactc cgaaaggcca atgcgagccg gctgattgac ggcgaacgcc
2600641 aacttggccc gaaaagaccg gcatttcact actatcaatg tgcctcgatc gtcgttggat
2600701 aacaaccgta gtgagtcgag aggaaccagt atgcagttcc tgagcgtgat tccagagcag
2600761 gtcgagtccg cggctcaaga tttggcgggc attcgctcag cgctgagcgc gtcttacgcg
2600821 gccgcagcgg gacccacaac agcggtggtt tccgctgccg aggacgaggt gtcgaccgcg
2600881 attgcgtcga tattcggcgc ctacggtcga cagtgccagg ttctcagcgc ccaggcctcc
2600941 gcgtttcatg acgagttcgt caacctgttg aaaactggcg cgactgcata ccgcaacacc
2601001 gaattcgcca acgcccaaag caacgtgctg aatgcagtga acgcaccggc ccgatcgctg
2601061 ttggggcacc cgagcgcggc tgagagcgtg cagaactcgg ccccaacgct aggcggtggc
2601121 cacagcaccg tgaccgctgg gcttgccgca caggccggtc gtgccgtcgc gacggtcgaa
2601181 caacaggctg cggctgcggt tgccccgttg ccaagcgccg gcgccggact ggctcaggtt
2601241 gtcaacggcg tcgtgaccgc cggacagggt tccgccgcca aacttgccac cgcgctgcag
2601301 agcgccgcgc cctggctggc caagagcggc ggcgagttca tcgtggctgg gcagagcgcg
2601361 ctgaccggtg ttgctttgct gcaacctgcc gtggtcggcg ttgttcaggc gggcggtacg
2601421 ttcttgaccg ccggaacgag cgctgctacc ggactgggtc tgctcacact tgctggtgtt
2601481 gagttcagtc aaggcgttgg caaccttgcg ctggcttcag ggaccgccgc gaccggactt
2601541 ggtctgctgg gcagtgccgg tgtgcaactg ttcagtcctg cctttttact ggctgtgccc
2601601 accgcgttgg gtggagttgg ctcgctcgcg atcgcagtag ttcagcttgt gcaaggcgtc
2601661 caacacctgt cgttggttgt gccgaacgtt gttgccggga tcgctgcact gcagaccgcc
2601721 ggtgcccagt ttgcccaggg tgttaaccac acgatgctgg ccgctcagct cggtgcccct
2601781 gggatagctg tcttacagac cgccggtggc cattttgctc aaggcattgg ccacctgacg
2601841 acggctggca atgccgctgt cacggtgctg atctcctagc cgggcggtcg agcttcatcc
2601901 cggagccgct acgttacgcc gagatgctgc acccggagaa tcggtccgat tgagttctgg
2601961 gaccgataag ttcggctggc gtcgatgccg gctgccgcac caaggccgcc tgcaacatcc
2602021 ccatgtcggt gaccgttcgg cggtcgtaca ctttccaagt cagaacggcg gcagcggcgt
2602081 agcacatcat gaagatccag aacgcatcgg tcccactgcc ggtgctgagg taggactcac
2602141 gcagcgccat attgattccg accccgccga gcgcgccgaa ggcggccaca aacccgatga
2602201 ctactcctga gatgatgcgt gaccagtcgc ggcgttcggc ttcactgaga tccagggagc
2602261 ggctgcacgc ctcaaaaatc gtcggaatca tcttgtacac agacccgttg cccaacccgg
2602321 ataggacgaa caacgcgacg aagcagacga agtagccgac catggtagcg ccccgatgct
2602381 ggccgacatg tcggccttcg agggtgctgg cactgatcag cagcccagcg gcgagcgtca
2602441 tcgccacaaa gactataagg gtcaagcggc ttccaccgac tcgatcggcc agccggccac
2602501 cgtaaatccg ggccaccgcc gccagcaacg gcccgacaaa cgccaactcg acggcatgca
2602561 gcgtcgcgcg cgccgggctt tgtccgcacg ccaggaagtt ggtctgcaac acctggccaa
2602621 acacgaagga gaagccgatg aatgagccga aagtgccgag gtagagcagc gagagcaacc
2602681 acgtgtcgcg ggtcgacaga accgcggaaa cgatcggccg aagccggttc acctgcaccc
2602741 ggtgctgttc gacattgttc atgaacagcg acactccgat taccgcgatt gccaccagaa
2602801 ccacatacag tgcgcagacc aggtaaggct tccgctcacc gacagtggcg attgccaaca
2602861 acccaactag ctggatcgcc ggcaccccga gattgcctac cccaccggca attccgagcg
2602921 ccgaaccctt gagccgatgt ggatagaaag cattggcgtt gctcattgac gacgcgaagt
2602981 tgccgccgcc taagccggtc agggccgcac acaccagata cggccacagc ggtagccccg
2603041 gatgggtcaa caacaccgtt gtgccaatgg ccggaattag caacacgatt gccgaaaaag
2603101 tcgcccagtt gcgaccgcca aagatcgcgc tggccaacgc gtagggcatc cgcaggaacg
2603161 cgccaaacag cgtcgcgatg gtgccgagca gaaacttgtc actggttgaa aagccgtaga
2603221 cgtcctgggg catcagcaac tccagcaccg gccagagcgt ccacaccgag taacccaggt
2603281 gaaccgtcac gaccgaccaa agcagattgc gtcgggcaat gcccttgttg cctgcctccc
2603341 acgctcctag atcctcggga tcccaatgcg tgatgtgacg tgagccaccc aggcgcctga
2603401 gcgaaggggc cgcgggactg cgcggcgact cctcgcgttg cagcagcgtg tgctgttcca
2603461 tcaccctcct tgttcccacc ctggtgcgaa tgcgggccgg cctaccaggg tgccagcctt
2603521 gcgtgtacga agttgtttcc tggcagcctg aaactcctgt agaactcctg taaaagtgct
2603581 gaaggcaata cacaattggg ctcgcccttg agccgagaag acctaaaccc tacatgtaaa
2603641 gctgcgctgt tgtcctcgca gcaagaaaac agcgaaagct attgtgctcg agtactactg
2603701 atgggggatc gagccgagcg cctcgagctt gccatctgat ccgatgtgga atcgcaccgt
2603761 gccgatgccg gtgggacagc actcctggtc gctgccgatc tgccattggt actgaaccgt
2603821 cacggtgtca tcgcctgcag gcaatacggt gatgtagggc ttcggattcc gagtcggcga
2603881 gcccagcggg atgttgcggt cgaagaacaa cagctgttgg ggagtcgact gggaggcaat
2603941 tgtcgggatg atttgcaccc aatgcaagcg gcagttgcgg gtatgtcctc gggtgatttc
2604001 gacccatttg gagcccggta ccacgatcgg gaccgcagcg atggcctgcc gtaccgtgtc
2604061 agcggtcggc ccgtcggaat ccttgcaggt gttcggtggt gacggtcgtg ttgtcggcgg
2604121 cttccaggcg caaccggagg cgcccagccc cacaatcagt gccaacagtg ccaacagtgc
2604181 caacagtgcc agaatcggga cggcgctacg ctgacgacgc acgtcacgag cttagcgaaa
2604241 actgggaatt tcccctacgt ttcatcaacg cctcaggtgt cgatcctaaa gcgcgggtgc
2604301 cgccggtatt cttgccccaa atcggtcggt tgacacccga tgcggtcggc gaagccatcg
2604361 gcatcgcggc cgacgacatc ccgatggcgg cacgctggat cggcagccga ccatgctcgc
2604421 tcatcggcca gcccaacacg atgggcgacg aaatgggtta cctgggacca ggtctagcgg
2604481 gtcagcggtg cgttgatcga ttggtcatgg gcgccagtcg atccacctgc tcccgattgc
2604541 cggtcatcgc gtccgtcgac gaacggctgt cggtgctcaa accagttcgg ccgcgcctgc
2604601 attcaatctc attcatcttt aagggccgcc ccggggaggt gtacctgacg gtcaccggtt
2604661 acaactttcg cggtgtgccg tagttcgggg tgtgctcgac ctgcctcgcc gagcgccccc
2604721 gacaatcggg tcgccatcta tgaaaggaca tctagcaaca ttcggccacc cagcgcttcc
2604781 gacataccga ggatcatggt tgagtcggga accgggatcc ccctaccggc ttcctgctgg
2604841 agccggacga gatcgaggcg atgcatgccg aaggattcct cgccgcactg gatctggcac
2604901 tcttctgcgg ccagggcagc gctgtacgtt cgcggcaaac gccgacccga tggccaaggg
2604961 cgtcgatcgt gcgctctgcg aaatcgtggc cgaacgccgg caactggacc tggacctggc
2605021 caaagcccaa gtccggtcgg cgctcgccaa ccagcgttac catcgcgacg tccattaaac
2605081 ccagcacggt cacgaacgga ggttgtgatg agcgacgccc gcgtgccacg gatcccggcc
2605141 gcgttgtccg caccaagtct caaccgtgga gtcggcttca cccacgcgca gcggcggcgg
2605201 ctggggctga ccggccggct tccgtcggcc gtgctcacgc tcgaccaaca ggccgaacgc
2605261 gtatggcatc agttgcagag cttggccacc gagctgggcc gcaacctgct tctcgaacag
2605321 ctgcactacc gccacgaggt gctgtacttc aaggtgctgg ccgaccattt gcccgaactg
2605381 atgccggtgg tgtacacgcc caccgttggc gaggcaatcc aacgcttctc cgacgaatac
2605441 cgcgggcaac gcggactgtt tctgagcatc gacgaacccg acgaaatcga ggaagccttc
2605501 aacacgttgg ggctggggcc cgaggacgtc gacctgatcg tgtgcaccga tgccgaggcg
2605561 atcctgggta tcggtgactg gggtgtgggt ggcatccaga tcgctgtggg caaattggcc
2605621 ctctacaccg ccggcggcgg cgtcgatccg cgccgctgcc tcgcggtgtc tctggatgtc
2605681 ggcaccgaca atgagcagct gctggccgat ccgttctatc tgggcaatcg ccacgcccgg
2605741 cggcgcggtc gggaatacga cgagttcgtc agtcgctata tcgaaacggc tcaacggtta
2605801 tttccgcgtg ccattctgca tttcgaggac ttcgggccgg cgaacgcgcg gaagatccta
2605861 gacacatacg gcacggatta ctgcgtgttc aacgatgaca tgcaaggaac cggcgcggtg
2605921 gtcttggccg ccgtatacag cggtctgaag gttaccggta tcccgctgcg cgatcagaca
2605981 atagtcgtct tcggcgcagg caccgcaggg atggggatcg ccgatcagat ccgggacgcg
2606041 atggtggcag acggtgccac gctcgagcag gcggtgtccc agatctggcc gatcgacagg
2606101 ccgggcctgt tgttcgacga catggatgac ctgcgcgact tccaagtgcc gtacgcgaaa
2606161 aaccgccacc agctcggtgt ggccgtcggg gatcgggtcg ggctgagcga cgcgatcaag
2606221 atcgcatcgc ccactatcct gctcggctgc tcaacggtct acggagcgtt caccaaagag
2606281 gtggtcgagg cgatgacggc gtcctgcaaa cacccgatga tctttccgct gtccaacccg
2606341 acgtcgcgca tggaagccat ccccgccgac gtgctggcgt ggtcgaatgg cagggcgctg
2606401 cttgccaccg gcagcccagt cgccccagtg gaattcgacg aaaccaccta cgtcatcggt
2606461 caggccaaca acgtgttggc gtttcccggc atcggactgg gcgtcattgt cgctggtgcc
2606521 cggttgataa ccaggcgcat gctgcatgca gcagcgaagg ccattgcgca ccaggccaat
2606581 ccgacaaatc ccggagactc gctgttgccg gatgtccaaa atctgcgggc catctcgaca
2606641 acggtcgccg aagctgtcta tcgggccgcc gtccaagacg gggtggcttc caggacgcac
2606701 gacgacgtca ggcaggccat agtcgacacc atgtggctcc cggcatatga ctaaccgcgc
2606761 actcgacggt catcgctgta ggcagcctct cgcttaggtc gctgcccgcg gtgtgcacgt
2606821 cacgcggaaa ccatcgccag ccggcgagaa acacgacagc cagtgttgca gtggcgacga
2606881 gcaacgccac ccgaatgcct tcgatgaaat cctcctccgc aatcgcgacg gggtcgcgat
2606941 gctcaatgtg ccgccggggg acgattccgc ccacatgcgc tcgcggattg gcactgtcga
2607001 taatgatctc ggcaaggacg tggcgctgga ccgggtcggg caccgcgcgc tccagatggg
2607061 gctcgagtgt ggccgaaagc caggcggcaa ggacggagcc caaaaccgcg aacccgatcg
2607121 tcgagccgat cgcccgctga gcactcatga tgccggacgc catgcccgca cgctcggcgg
2607181 ggaccgcggt catggcgacg gtcgtgatcg gcgtcaggca caacgcgacg ccgctcccgc
2607241 acaagcccag cccgaccagg accagggccg agctccggtg ctcgctgaag atgagcatga
2607301 gcagacccag catcaacatg cacagccccg ccaggatggg aacgcgtgct ccgatccggc
2607361 caaccaggtg cccaacaagt ggcgacacga tggccacggc cgcactgaac ggaaggatca
2607421 tcaggccggt cacgctcggg gtatagccgc gcacgttctg caggaactgg gtggtgagca
2607481 gcagcatccc atagacggcg aagaacaccg tgcagatggt cgcgatggcc agggcgtatg
2607541 aggtgtcgcg gaacagggtc agatccatca tcggattcga tgatctgcgc tcaagccaga
2607601 cgaacagggc gcagccgacg gcggctgtcc agagcatcac gatggtctgg acagacgtcc
2607661 agccgatctg ggggccttcg atgaccgcat acaccagggc acccacggca acgatgaaca
2607721 gcagctgccc ggacagatcg aagcggcgtg cccgctcgtt acacgactcc tcgacgtagc
2607781 acaaagtcag gaagaggacg agtgcgccca tgggcaggtt gacatagaag atgctgcgcc
2607841 acccccactg gtccaccagc agaccgccca gtgtcgggcc cgtcgtcgta ccgatgctcg
2607901 cgatggcggt ccagatcccg atggcgcgcg ccttctcctt cgcctccgga aaggccgcgc
2607961 tgaccagggc gagcgaggtt acgctgacgg ccgccgcacc taggccctgc gcgccccgcg
2608021 cggtggtgag caccgcgatt gagggcgcca acccgcaggc gatagatccc agcgtgaaca
2608081 acgaaacacc tatcaagtac cagcggcgcc gaccgtcgag gtcggcaagc gtcgccgccg
2608141 acatgatgaa gaccgccatt ccgaggctgt aggacgccac cacccactgc aggccgtcct
2608201 cccccaccgc gaaactgcgc tggatgtcgg gcagcgccac gttcacgatc agtgcgtcga
2608261 gaaagatcat gaacaggccc aggccagtgg cgatgagcgt gaggagctgc gtgcggttca
2608321 tgcgggcccc gatctacatg gatttcggtg gcgatctgtg accagacact aggctgcgcc
2608381 agcgacggcg tcagccgctt cggtcgattc gagccgaatg gtcgacggct gcggaaccga
2608441 ccgcaaaact ggggcaaaag gttcaccgcg ggtgtaagcc agctaggtga accgatcccg
2608501 ctggcccatg gcctatagtg ggcccatgca acaggccata cagctgcgct ttatcctccc
2608561 gcgccgcctc gccgtgggct gttgttgttg ttgattcctg gcgtccacag caatcctcgc
2608621 gctcttgccc gcaaacgggt ggaaatcggt gttcgcccgc ggcgtacagc cgccgcgcac
2608681 tcacgagtcg ttcagaaaga tcaacagcca tgaccgtgcc cacggatgca gccatcgact
2608741 tcgacgtcag ctgggaggcc aactgggcct ggaccgacac tgttgggcgt agcagatgag
2608801 catcgccgag gacatcaccc aactcatcgg gcgcacaccg ctggtccgac tgcgccgagt
2608861 caccgacggc gccgttgccg acatcgtcgc caagctggaa ttcttcaacc cggccaacag
2608921 cgtaaaagac cgtatcgggg ttgccatgct ccaagcggcc gagcaggcag gtttgatcaa
2608981 gccggacacg atcattctcg aacccacgag cggtaacacc ggcatcgccc tggccatggt
2609041 ttgcgcggca cgcggctacc ggtgcgtgct gaccatgccc gagacgatga gtctggagcg
2609101 ccggatgttg ctgcgcgcat acggtgctga actcatcctc actccgggtg cggacggcat
2609161 gtcaggtgcc atcgccaagg ctgaggagct ggccaagacc gatcaacgct acttcgtgcc
2609221 ccagcaattc gagaacccgg cgaacccggc catccatcgc gtcacgaccg ccgaggaggt
2609281 ctggcgtgac accgacggca aggtcgacat cgtcgtcgcg ggagtcggca ccggtggcac
2609341 catcaccggc gtcgcgcagg tcatcaagga acgcaagccg tcggcccggt tcgtggccgt
2609401 agagccggcc gcgtcgccgg tcctttctgg tggccagaag ggaccgcacc cgatccaggg
2609461 catcggcgcc gggttcgtcc cgccggtact cgaccaggac ctagtcgacg agatcattac
2609521 cgtcggtaac gaagacgcgc tcaacgtggc gcgccggctg gcccgggaag agggcttgct
2609581 ggtcggcatc tcctcgggcg ccgccacagt ggccgctctt caggtggccc gccggccaga
2609641 gaacgccggg aagctaatcg tcgtagtgct ccccgacttc ggcgaacgat atctgagcac
2609701 accgttgttc gccgacgtgg ctgactaagc catgctgacg gccatgcggg gcgacatccg
2609761 agcagcccgg gagcgggatc cggcggcccc taccgcgctg gaagtcatct tctgctaccc
2609821 gggcgtgcac gccgtgtggg gccaccgcct cgcccactgg ctgtggcagc gtggcgccag
2609881 gctgctcgcg cgggcagctg ccgaattcac tcgcatcctg accggtgtag atatccaccc
2609941 cggtgccgtc atcggtgctc gcgtgttcat cgaccacgcg accggcgtgg tgatcggaga
2610001 aaccgcggag gtcggcgacg acgtcacgat ctatcacggc gtcactctcg gcggcagtgg
2610061 catggttggc gggaaacgcc atcccaccgt cggtgaccgc gtgatcatcg gcgccggggc
2610121 caaggtcctc ggtccgatca agatcggcga ggacagccgg atcggcgcca atgccgtcgt
2610181 ggtcaagccc gtcccgccga gcgcggtggt ggtcggggtg cccgggcagg tcatcggcca
2610241 aagccagccc agtcccggcg gcccgtttga ttggaggctg cccgatctcg tgggagccag
2610301 cctcgattcg ctgctcacca gggtggccag gctggaggcc ctcggcggcg gcccgcaagc
2610361 agcaggagtc atccggccac ccgaagccgg gatatggcac ggcgaggact tctcgatctg
2610421 aggcaatacc cggccgccga caatgccttc ttcggcgccg cccaccgacg cgcatcatcg
2610481 gctgctagcc cccgcaccgg gttccgtcct cgccgaattc acctcgggcc ggaggttgag
2610541 ctgcttgggc ttcggcagcc gaaaccgggg cgatacaaac gtgggttgcg gatacgaccg
2610601 ctttgcgacg cggtttgtcc aacgcaggct tggaaaactt ctccaagcac gagcgagatt
2610661 actgattcga attggctctt gacagcaccg gcgaagaggt gtagagatgc gaatcactat
2610721 gtggacagca atctttggaa agctcttgct gtcaaatccg tcacgaacct atgcttagcg
2610781 ataccttgcg ccaaacatgc agtcgcttga ccgttgagat cgctgaggta tcggccatgg
2610841 atgtccctca cgagcagcca gccctctctt cgagcaaatc gaatcgcttt acttcgcaaa
2610901 ggcaaacaac tggtgtggga accaccactg ttgaacggct cgaaccgcgg ttatctcccg
2610961 cgtcccgcca catcactgag gctaaagctt tcggcaccga gtgccacgta agttccttta
2611021 cccgtgagca ggatcccgac agggcggtcc gtgtggagca gatccacggt gaagcgtatg
2611081 tcgccgccgg ccatgtgtac gaatctgcgc tcgatgaatt gggccggctg gacaattcca
2611141 acgccgagtt catcctcgac aaggcacgcg gtagcacccg agaaaccgag gtcatatacc
2611201 tgcatgcggt tcccgcggag cccctctccg gcagccaagg cgaaggaggc ctgcgaatag
2611261 tcggcatttc cgctgtgggg tcaattgacg acctcagtgc atttaaggcc gccaaaccgt
2611321 cgatgggcct ggcgcatcaa cgcaagcttt atgacgcgat cgaagacctg ggtcacggcg
2611381 gggtcaagga gattgcggca ttatcggtta cggccgatgc ccctcccacg gtgtcgtatt
2611441 cgctcatccg ggaggttttg cgcttgtacc accgaaccgg cgaaaaattg ataatcacat
2611501 ttgccatgcc agcatacgcc aagatggtga tgaattttgg tcgatttgcg atgcctcaag
2611561 tgggcgaacc gttctatgcg cacagaaata atgaccctag gacatcgaat gatctcttgc
2611621 tggttccctc aatagtcgag ccatcgaatt ttctcgagaa tatttcccgc ggggtcgtga
2611681 cagcggatga cggcccgacc gcgagaaggc gattcgccac cctatgctat atgaccgacg
2611741 gccttgatga ctatttcatg ccgttgactc ggcaggtcct tagcgaagga atccaagaca
2611801 tctgagttct ggaagcggta atgggcggtc gggcgtgcgc aactccggca acaaacagct
2611861 tggagctttt acgcgaagcg ggattcacta tccgaaccag accgctcggc aggggcatag
2611921 caataagctt caaccgattg acgcattgtg cgaactgacg gcgcccgcgc atggccaatc
2611981 cggaagacca tcattggcca gtggccgggc gctaacaggt tccagccccc caccagtgcc
2612041 gctcgaacat gcggtgcaac ccattcgcag gccggcaggg aaagcaccgc ggaagccgca
2612101 aagggctgca gttccgcgcc caatagtgtc gtccgcaacc agatgcgctc gaaaaccgcg
2612161 ccggcagtca gcgcacccga cgcgaggtcg agagacgtcg tcagcgcgcc cacatggggt
2612221 gccaatcggc acggcaggta ggccgcgcgc aacccgagcg cgtggtgcat gcccacggtc
2612281 cgcaggaggc gcagcacccg ccaatgccga agcccacgaa acatcgggcg catccacgct
2612341 tcaacctcaa gagacccggg cggcaaccca tcgtcgctgc tcgcggtcca gccaatgtcg
2612401 aagcggacgg ccgaaaagag ttcttcgtgt agttcacgag atcgaaagcg ctcagtttcg
2612461 gccaatctga ccaaccgaag gatctgtttc ctggtctctg gcgagtcaaa ccaatgcagt
2612521 tggatcccgt caatgccggt ggcctccgcc gagagtgcac ccaattcgcc ctgcgaaagt
2612581 ggcggtccac gaaagcgaac acgccggttg gtgcgccttc gctcgatcgc gccctcgatt
2612641 ggatccaccc tggtttgtgg caggcgatcc acgtcgatct ccgccaccag ccccggattc
2612701 ccgctatccg gaaaccagca caccttcgtt tcaaaaccaa ggcgtccagc gcgcagcttc
2612761 acgttttcga cagccgcacc gatcgcgacc aaactcatga tgcggcggtg ctcgggggcg
2612821 gacctccaag tctgatcgcc ccacaaccgc acccgcctac cggcatgttc gagctggact
2612881 tcgcgccggt tgtccgcgga tggcgccagc gccgccgcct cgacgagcga caggaattca
2612941 gcaggatcca gacccgtcat acccgggccc cagcggccgg cacgcattgc cgtggcagag
2613001 tggtcgcgcc gacgaacagt gcggaagcga tatgtctatc ccatgttcgc tcaaacagcg
2613061 gtgcgctggc agtatctgag tacaccattc taggtgcagc tcccaactag tagctcggtt
2613121 ccgtcctgtg ataccgcagt cccggtatta cccccgccga tcgtcgattt atgtagcggg
2613181 ccagcaatcg ccgcttgact ctctgtagag ggtggcgatt tccgcaccgt aaacgcttcc
2613241 gaacatagat gctgcggtaa gcatcgaact gatgaaagta gggagcagcg taaacgcgcc
2613301 catgtccgag cagaatcttc aacacctcgg ccgccaccac accggaagcc agatgacagg
2613361 cgaggccaac cgatggaccc gtgcgatttt cgatgtcgac gtaggacaga tctatggagc
2613421 gccgatgcgt cgcggatggt gctattccag ctataaatgc gacgaactta tccaccgtgt
2613481 tcatcgcatc agacagatcg aaataccgat cgaacgtcat acccttagga tcgaaaacga
2613541 cccaggccgt actgaacccg agcgggccag cgcctagcgc gtagattccc cgctgctgtg
2613601 cttcacgata gagcaggcga cgcaaatcga tttcgaacgc gtcgatgccg tccaccaaaa
2613661 catctgctcc ctctagaaag gtagctgcat tctctttccc aataggttcg cagaaagcac
2613721 ggatttctgc ttcagggtta atatcatgaa cgatattgcg catgacctct gccttggcct
2613781 ggccgttggt cgagcgcata gcgccgtact gccgattcga gttgcgtatt tcgaagacgt
2613841 ccgggtctgc aatggtgaac tttcctattc ccatccttgc gagggcgacc atgtcaattc
2613901 ccccaacccc acccatccca gcgattgcaa cgcgactatt ccgaagccgt tgttgttcgg
2613961 ttgggctaat caatccaagg ttgcgacaga aagcttcgtc ataagaccat ggtgcgcttt
2614021 ctttcacccg tccagagtcg ggggcatccg caccggctcg catcgcatca tcctcccacg
2614081 acgggccgct catcagcttg ggccatttca atgtacttga taccccgcgc tgcgggtagg
2614141 ccactgcgac gattcaaaca cggtgtcaca cggtgaatag tgtcgagatg ggctctgatc
2614201 aaccgtcgca aacccggttt cgcatcgata gcggaatcgc accgggttgc atggaggctg
2614261 ctgaccttgg aaaacaagat gtattcatta cgacaaaaca agcgccgcgg aaactttgca
2614321 cgctcgagca ttccgccgcg gctcacgcac atcctggccg ccttcccgca accgtccccc
2614381 ggaattactg atcaaaccct gggtttacca acttccgggc atggggcgaa ggtcgacagc
2614441 cagaacatgg ccgtgcgtga tatgggcatt cacgggacgg agccgctaag gagaccggta
2614501 cgattcaatc tccatatgag cggtgcggcg gctgttgtca ggtacgttga acaccggtgg
2614561 cgatcgggtg ccggcaggtt ggtcttctcc tgtgatgcga gcgcgcctcc gcgccaacca
2614621 ccgcgtgcga agcaggtgct gatgccacag tgctgatgtc acaaggaacc gcgagggggt
2614681 cccggaccct acatggtgcc gggcgaagtc cacatgagtg atacgccgtc aggcccgcac
2614741 ccaatcatcc cgcggacgat tcgcctggcc gcgattccca tcttgctgtg ttggctggga
2614801 tttaccgttt tcgtcagcgt cgccgttcct ccgttggagg cgatcggtga aacccgggcc
2614861 gtggcagttg cccccgacga tgcgcaatcg atgcgtgcga tgcgacgtgc cggaaaggtg
2614921 ttcaacgaat tcgattccaa tagcatcgcg atggtcgtcc tggaaagcga tcaaccacta
2614981 ggcgagaagg cccataggta ttacgaccac ctggtcgata cgctcgtact ggaccagagc
2615041 catatccagc acattcaaga cttttggcgt gatcccctga cggcggcggg tgcggtcagc
2615101 gcagatggta aggcggcgta cgttcaactt tacctcgccg gcaacatggg tgaagcactc
2615161 gcaaacgaat ccgttgaagc cgtccggaaa attgtggcga atagtacacc gccggaaggc
2615221 atcagaacct atgtcaccgg accggcggcc ttgtttgccg accaaatcgc cgccggtgac
2615281 cgaagcatga agctgatcac cggattaacg ttcgcggtaa tcaccgtgtt gctgctgctc
2615341 gtctatcgct cgatcgccac cacgctgctg attcttccca tggtgtttat tggactcggc
2615401 gcgacgcgtg gcaccattgc ctttcttgga taccacggaa tggtcggcct ttcgactttt
2615461 gtggtcaata tcctcacggc acttgccatt gctgccggta cagactacgc gatcttcctg
2615521 gtcggccgct atcaagaagc ccgccatatc ggccagaatc gcgaagcctc tttctacacg
2615581 atgtacaggg gcaccgctaa cgtcattctc ggatcgggac tgaccatcgc cggcgcaaca
2615641 tattgtctga gtttcgcccg gctgacgctg tttcacacca tggggcctcc gttggcaata
2615701 ggcatgctgg tttcggtcgc ggccgcgctg accctggcgc ccgccatcat tgccatcgcc
2615761 ggccgcttcg gcttgctcga ccccaagcga agactgaaga ccaggggctg gcgtcgtgtg
2615821 ggtaccgcag tcgtgcgctg gcccgggcca attctggcca cgtcggtcgc gcttgccctg
2615881 gtgggattgc tcgcactacc gggctaccgg cccggctata acgatcgcta ctacctgcgc
2615941 gctggcacgc ctgtcaaccg cgggtatgcg gccgccgacc ggcactttgg cccagcccgg
2616001 atgaaccccg agatgctgct ggtcgagagc gatcaagaca tgcgaaatcc ggccgggatg
2616061 ctcgtcatcg acaagatcgc caaggaggtc ctgcacgtgt ccggggtcga gcgggtgcaa
2616121 gcgatcaccc ggccgcaggg ggtgcccctt gagcatgcgt cgattccctt tcagatcagc
2616181 atgatgggtg ccacccagac gatgagcctg ccctacatgc gcgaacgcat ggccgatatg
2616241 ttgaccatga gcgacgaaat gctggttgcg atcaattcca tggaacagat gctcgacttg
2616301 gtgcagcagc tcaacgacgt tacccatgag atggcagcca cgacgcgcga gatcaaagct
2616361 actaccagcg aactgcgaga tcaccttgcg gacatcgacg atttcgtcag gccgttgcgt
2616421 agctatttct actgggagca ccattgcttc gacattccgt tgtgctcggc gacgcgatca
2616481 ctgtttgaca ccctagacgg cgtcgacacg ctgactgacc aattgcgggc ccttaccgac
2616541 gacatgaata agatggaggc gctcacaccg caatttctcg cactgctgcc gccaatgatc
2616601 acgaccatga agaccatgcg gaccatgatg ttgaccatgc gatcaacaat aagtggcgta
2616661 caagatcaaa tggccgatat gcaagaccat gcgactgcga tggggcaggc cttcgacacc
2616721 gcaaaaagcg gcgattcatt ctatcttcct ccggaagcct tcgataatgc agaattccag
2616781 caaggcatga agttgttttt gtcgccgaat ggtaaggcgg tgcgcttcgt aatttcccac
2616841 gagagcgatc cagcaagtac tgaaggtatc gatcgcatcg aagcgataag ggccgcgacc
2616901 aaagatgcca tcaaggcgac accattgcaa ggcgctaaaa tctatatcgg tggcacggct
2616961 gcgacctacc aagacattcg agacggtacc aagtacgata tcctcatcgt tggtatagcc
2617021 gcggtatgcc tggtatttat tgtcatgctc atgattaccc agagcctgat tgcgtcactc
2617081 gtcattgttg gcacggtact tctgtcattg ggtactgcgt tcggactgtc cgtgctcatc
2617141 tggcagcact ttgtcggtct ccaggtgcat tggacgatcg tcgcgatgtc tgtcatcgtc
2617201 ttgctggccg tcggttctga ctacaacctc cttttggtgt cccggttcaa ggaggaggtc
2617261 ggcgctggat taaagaccgg gatcatccgg gcgatggccg gcaccggcgc agttgtcacg
2617321 tcggccggtc tggtattcgc gttcaccatg gcgtccatgg ccgtcagcga actccgcgtt
2617381 atcggacagg tcggcaccac catcgggctc ggtctacttt tcgataccct ggtggtccga
2617441 tcgttcatga cgccatccat cgcagcgctg ctaggtcgct ggttctggtg gccgaacatg
2617501 atccactcga gacccaccgt cccggaggcg cacacacgcc agggcgctcg ccgaattcag
2617561 ccgcatctgc accggggttg atatgcactt cggtgccgtg atcggcgccc ggggtgttcg
2617621 tcgaccatgc gaccggcaac gcggccttgc gcacaggcgc gatcgctcat tcgtgcccgg
2617681 gcggtcgaag accaagagcg cgcagcagtt ggtcgcggtc ccacggccgg ccgctgccac
2617741 tagcattgtc gccggatgct gtcagcagcc catttcgagc tcgaagcccg gacaacttct
2617801 ttagcgtgtg gcgcaacccc cgaagactcg tcaacggaag aagcagtagc tgctcatcgc
2617861 gcccgccatc agcccggcgc gccgagttgc ccgggtcggc cgggttgccc tggtgtgccg
2617921 cgttgccggg gttggtcgtc gcgtgcatcg cctgcgcctt ggtcgccggc gtcgagccgg
2617981 attcggctgc caccgcagac gtggtagccg gcgacaccgc aggtgccgtg gctaccgcag
2618041 gtgccacctg ttcacccact ccgccgatag caccggaatg gccttcaccg ccgagccccc
2618101 agtgcccgcc aacccacgga gccccaccga agccgggcat caacccgccc tcagcagaag
2618161 cgcccgcagc gccggtgctc agaccgccgt caccgctggc catgccgact ccgccgtccc
2618221 cgcgaacaga cccgacgatg tccctgccag tcccggcacc accgactgcg tctgcgctgc
2618281 cggccccagt cccattgccg gctgcgctac cgaccccagc accactgcca cccgggtccg
2618341 cgacaccggc ggcacctgtt gcgccgctgc cgtgcgaagc agaaacgccg ctgccgtgcg
2618401 cggcgccagc cactccgggg ttaccgtcgg tgctgccgag ctggccggcc ccatgctgct
2618461 cgccgacctg accgttgccg atcggtccgc cgtcccagcc ctttccgcca gcctggccga
2618521 caccgccaaa cccgccggca ccgcgagatt gcccggtgcc cgtcccccca gtgcgatctt
2618581 gggcgagttc gctgaccacg ccctgcgctt tctgcagcgg caaggcgttg gcggcctcag
2618641 ccatggcata cgccgccgcg ccctcttgca ggatctgtac aaaccggtcg tgaaacagcg
2618701 ccgcttgagc gctaatggcc tgataggcct gcgcccgcgc gccaaacaac gccgcgatgc
2618761 cagccgacac gtcatcgccg ccggcagcca gcactcctgc cgtcggggcg gccgcagcgg
2618821 cgttggccgc gcgcatagtg gagccgatcg cggctagctc cccggccgac gccgccagaa
2618881 cgttcggggc cgcggtaacg tgcgacataa gcgagcacct gcccgtgttg ccaactcgct
2618941 gtgaccggat cgctggtcga cccgcgttgt caccgcgaat cctatcgcga tcgaccagga
2619001 acatcccagc attcaggcat gcctactgcg cctcacactg aagtgtcgag gtcggcggag
2619061 tcccggcatc atcaggcgag tggcatgcac tcaccaaccg cggccagctc ggcaccagct
2619121 tggtgtcggc gcacagagct gttcgggccc atacgtcgac gtagccgaac ccgccccgac
2619181 tctcgtcgga cacgttctgc tgtttggcgt ggccgaacga tcagatctcg tcgcgccgaa
2619241 cgtgtattgc cgggccggtg gaagagtctg tcgggagaaa aaggaaaagc cctgcagaga
2619301 ctggtgtgac acgccttgcg cagccacgcg gtcggaaaac cgaaccttag ctcatcagaa
2619361 cccaacacaa gaggcgggac aagccgagtt caagccgaac gccctgctcc cccgggagga
2619421 ctcgaacctc caacccttcg gttaacagcc gaacgctctg ccaattgagc tacaggggac
2619481 cgcctggtcc gtgcgaacgc tggcgcagtc gcgggacgac tctagcgtac tggtgtgacg
2619541 gcgcccaact agggagattc cttaccgatg ggagcaggct gatggcagca ggcacgatgc
2619601 cagtaggtgg tcggcagcac gttttcgaga agctggccag catcctgggc ttggtcgccg
2619661 cgccgctcat gctccttgga ttgagtgcct gcggccgcag cgccggcaag accagcgaac
2619721 cgacctgccc cacggagccg atcgatgcgg ccgacagctc gacaacaccg gacccctcgt
2619781 gtgtggtgcg ggccactgag atcaacggca acgggtcgcg catccagacc tggaccggca
2619841 gctatgatgc ggccgcaacc cagtccggtg gtgtgtgtgg tggcacctgc aacttccacg
2619901 ccacagtgcg gttcacggtc gacgaaggcc agatctcggg cagcgtcgat caggtctatc
2619961 aagcggcgat ggttgctatc gcaacacgcc ccacttcgcc atctctggca ccatgacgat
2620021 gacgcggtga ccatcgcgtg atccaagacg tacctgacgg gcaataagcc gataccaaag
2620081 ccgagcccgc atcacgccga aacaaccgcg gagtatctgc tcggcgtcgt gaattgggtg
2620141 accaagtgga acctcgattg cgtcgaaggc tgcaaatagg acatcgggta ccgcataacc
2620201 ggatcgggcg cgcgtagcca ggcgtgtaag gcaggatgga tgcaaccgca ccgttagtcg
2620261 gagggaccgc attgatcggg tatgtcgccg tgttgggact gggttacgtg ctgggcgcaa
2620321 aagccgggcg ccgccgctac gagcagatcg cgagcaccta tcgcgcactc accggcagcc
2620381 ccgtggccag gtcgatgatc gaaggcgggc gtcgcaagat cgccaatcgg atctcacccg
2620441 atgctgggtt tgtgaccctg gccgagatcg acaaccagac cgccgttgtc cagcgcgggg
2620501 tcgagcggca gccgaaaacc gcgcgctgac cctcacgcgg tgagatcgtc gccgctggcc
2620561 tgctctaaca ggctgcgccg ataggcctcc atggcgacca ggtcgccgaa cagcgcgtgg
2620621 tattcgtcgc cttgctcgat cggcgacatg cgctgcagtt tggacttcac ctcggcgatc
2620681 tgccgcccca accaaacctc ctgcagacgg gccagcacgc cggcgatata gcgcggcagc
2620741 ttgtcgtcgt cgacctgaat cgcctccacc cccagctcgc tgatcaaagc cgaggtcacg
2620801 gttgatgtcg tctgctggcg caccatatcc agccactgcg caccgctaag gccagccgag
2620861 gtaccgcccg ccgtgtcgat ggccgcgcgc acagccgcgt actcggggtg cgtgaagcct
2620921 tcgacggtca gcgcgtcgaa caccgggccg gccaacgccg ggtactgcaa cgccgatttg
2620981 agtgcctcac gctgtggcca cagggtcggg tcacgcggat caggtcggac tgcgagttcg
2621041 gtcggggggc cggcggtggg ccgctgcgct gcccgggcga tggtcgtcga tcccagtctg
2621101 cccagcctgg ggtgcttggt tcgtttggcc tcaccccgca cccgaccgat gacctgtgcg
2621161 acgtcggccc acccgaccca gccggcgagc tgacgggcgt attcgtcacg cagcgtgggg
2621221 tctttgatct ggcccaccat cggtacgcaa cggcgcagcg cggccaccct gccctcggcg
2621281 ctatccaggt ccatctcggc aatcgcggcg cgaatcgcga actcgaacaa tggggttcgt
2621341 cgtgccacga ggtcgcgcag ggcagcgtcg ccgcacttca gtcgtaggtc gcaggggtcc
2621401 atgccgtcgg gagccaccgc gacgaaagac tgaccagcca gcttctgctc accgtcgaag
2621461 gccttgagcg cggcggcgcg gccggcctcg tcgccgtcga aaacgtagat cagctcgccg
2621521 cggaagaagc tgtcgtccat catcagtctg cgcagcatcg ccaggtgctc gccgccgaat
2621581 gcggtcccgc acgacgccac cgcggtggtg accccggcca gatgcatggc catgacatcg
2621641 gtgtagccct cgacgacgac ggcctgatgt cccttggcga tgtcgcgttt ggccaagtcg
2621701 atgccgaaca tcaccgatga cttcttgtac agcaatgtct cgggcgtgtt gacgtacttg
2621761 gcctccatcg cgtcgtcgtc gaacagtcgc cgggcaccga acccgaccac ctcgccggcc
2621821 gaggtgcgga tgggccacag cagccgacgg tgaaaccggt ccatcgggcc gtgccggccc
2621881 tgccgggaca gtcccgcggc ctccagttcc tcgaactcaa aacccttgcg ctgcagatgt
2621941 tttgtcaatg agtcccagcc cgacggggcg aacccacagc cgaatttacg agcggccgcc
2622001 gcgtcgaagc tgcgttcggt caggtactgg cgagccggtg ccgcctcgtc ggactgcagc
2622061 gcctgcgcat agaacgctgc cgcggccgcg ttggcggcca gcagcctgct gcgactgccg
2622121 cggtcgcgct gcacgctggt ggccgcaccg gtgtagctga tcgtgtggcc gatccggtcg
2622181 gcaagcaact caaccgcctc gacgaagctg acgtgctcga tcttctggat gaacgcatac
2622241 acgtcgccgc cctcgccgca gccgaagcag tggaagtggc cgtggttggg ccgcacgtga
2622301 aaggacgggg acttctcgtt gtgaaacggg cacagcccct tcagcgaatc ggcaccggca
2622361 cgcctgagct ggacatagtc gccgacgaca tcctcgatac gggccccctc gcggattgcc
2622421 gcgatatcgc gatcggagat ccggccggac atcggctcag tctaaagcgt tcctgctgac
2622481 gccaagctga tcggcatcga tgcgttccaa ccgaccctcg gtataggagg cgatctgatc
2622541 aacgacgacc cgcaaccggg cagcgtcgtc ggcggcggta ttgaacgcag cggcataaac
2622601 cgggtcgagc gtctgcggcg cccccgagta cagcctgtgc gccacccggt gaatacgttc
2622661 gcgctgccgt gcctgggttt ccagatgccg agggtcggac atgatgaact gcagcgcgag
2622721 gattttcagt accgcgacct cggcacgtac cagatcgggc acctgcaggt cggcccggaa
2622781 gcgcaccaac ggtcccggac cggccgcggc ccgggtggtc gcgatcgcgg ccgatgcaaa
2622841 gcggcccacc agctcgctgg tcaaccgctt gagcgcgacc gatgccgaca aggtggcgtc
2622901 atacttgccg acggcggcca ccacgggcag ccgcgacagc cgccgcgcgg ccgccatcaa
2622961 ctcgtcggcg ctcacccggg agaactcgcg ctcccctaac ctggccagcg cggcagcgtc
2623021 ctcttcggcg gccagcacac gcaggtcgat gcgttcggag acaacgccgt cctcgacgtc
2623081 gtgaaccgag taggcgacgt cgtcggccca gtccatcacc tgcgcttcca ggcacgcccg
2623141 ctccgggggc gcgccttgcc gaacccatac cgccgattcg cggtcgtcgt cgtagaagcc
2623201 gaacttcctc cgctggctgc caagcccgtc accacgcatc cacggatact tggtgaccgc
2623261 gtccagggac gcgcgagtta ggttcagccc cgcactaagt ccttgtgcgt caactacttt
2623321 gggctcaagg ctggtcaaga tacggaagtt ctgcgcgttg ccctcgaaac cgccgtggct
2623381 ggctgcgact tcatcaagcg cccgctcacc gttgtgtcca tacggcgggt gcccgatgtc
2623441 atgggctaga ccggccaatt cgaccagatc aaggtcgcag cccagcccga tcgccattcc
2623501 ccgtccgatc tgagccactt ccagcgagtg ggtcagccgg gtacgcggcg tatccccttc
2623561 ccggggtccg accacctggg tcttgtcggc tagccggcgc agtgcggcgc tgtgcagcac
2623621 ccgggcccgg tcccgggcga agtcggagcg gtactgaccc tcagtgcccg gcagaccggc
2623681 agtctttggc gcttcggcta cccgccgctg gcggtcgaag tcgtcgtagg ggtcgtgctc
2623741 actcgcgctc accgacccac agtctgccag ggtggtcgcc gcacgcccgt atccgccggc
2623801 acagcgtcta aattgacggt atgcgtctcg ttcgcctgct cggcatggtc ctgactatcc
2623861 tcgccgccgg gctgctgctg gggccgcccg ctggcgcgca accacctttc cggctgtcga
2623921 actacgtgac cgacaacgcg ggcgtgctga ctagctccgg tcgcaccgcg gtgacggcgg
2623981 ccgtcgaccg gctctatgcc gatcgccgca tccgactgtg ggtggtctac gtcgagaact
2624041 tctccggtca gagtgcgctc aactgggcgc agcgcacgac gcggactagc gagctgggta
2624101 actatgacgc gcttctggcc gtggccacca ccggtcgcga atatgccttt ctagtgccat
2624161 ccgcgatgcc gggtgtcagc gaggggcagg tcgacaacgt gcggcgctat cagatcgaac
2624221 cggcgctgca cgacggcgac tacagcggcg cggccgttgc ggcggcgaac ggactcaacc
2624281 ggtcacccag ttcgtcgagt cgagtggtgt tgttggtcac ggtcggcatc atcgtcatcg
2624341 tcgtcgcggt cctgctggtg gtgatgcgcc accgcaaccg gcggcgccgc gccgacgagc
2624401 tggccgcggc acgccgcgtc gaccctacca acgtaatggc actggccgcc gtgccgcttc
2624461 aggccctcga tgacctctcc cggtcgatgg tggtagacgt cgacaacgcc gtgcgcacca
2624521 gcaccaacga gctcgcgctg gccatcgagg agttcggcga acggcgaacc gcaccgttta
2624581 cccaagcggt gaacaacgcc aaagcggctc tgtcccaggc gttcaccgta cgccaacaac
2624641 ttgatgacaa cacgcccgag acgccggcgc agcgacgtga gctactcacc cgagtgatcg
2624701 tgtcggcggc gcacgccgac cgtgaactcg cgtcgcaaac cgaggccttc gagaagctac
2624761 gcgatttggt gatcaacgcc ccggcccggc ttgatctgct cacccagcag tacgtcgaac
2624821 tgaccacccg gatcggcccg actcagcaac gcctggccga gctgcatacc gaattcgacg
2624881 ctgcggcgat gacgtcgatc gccggcaatg tcaccaccgc caccgagcgg ctggcgttcg
2624941 ccgaccgtaa catcagcgcg gctcgggatc tggccgacca ggcagtgagc ggacggcaag
2625001 ccggactggt ggatgcggtg cgtgccgccg agtcggcact cgggcaagcc cgggcgctgc
2625061 tcgacgcggt ggacagcgcc gccaccgaca tccggcacgc cgtcgcgtcg ctgccggcgg
2625121 tcgtggccga catccagacg ggcatcaagc gagccaacca acacctacag caggcgcaac
2625181 aaccccaaac cgggcgcacc ggtgacctga tcgcagcccg cgatgcggcg gccagggccc
2625241 tcgatcgcgc gcgcggagcc gccgatccgt tgaccgcatt tgaccagttg accaaggtcg
2625301 acgctgacct cgaccggctg ctcgccaccc tggccgaaga acaggcaacc gccgatcggc
2625361 tcaaccgctc acttgagcag gcgctgttta ccgcggagtc gcgggtgcgc gccgtctcgg
2625421 agtacatcga cacccgccgc ggcagcatcg ggccggaggc ccggacccgg ctggccgagg
2625481 cgaaacggca gctggaagcc gcacatgacc ggaaatcgag caacccgacc gaagcgatcg
2625541 cctacgctaa cgcggcatcg acgctggccg cacatgcgca gtcgctggcc aatgccgacg
2625601 tgcaatccgc ccagcgcgca tacacccgtc gtgggggcaa caacgccggc gcgatcctcg
2625661 gtggcatcat catcggcgac ctgcttagcg gaggcaccag aggcgggttg ggtggatgga
2625721 tccccacgtc gttcggcggt tcgtcgaacg cgccgggaag ttcacccgac ggcgggttct
2625781 tgggcggcgg cgggcggttc taagccacgc gccagcgcac ggggataccc gtacgctggc
2625841 gcgtgtggcc gtcgacctag gcttcttcct agggttcgtc gaccctgtca ggcccagctg
2625901 gagccgacgg cgctgtcggt ttgtgccatg ttgttgccgg cagcctgcac cttctgcccg
2625961 tgggcgttgg cctgctcgta gatcacctgg aagttacggc ccagctgggt gatgaactcc
2626021 tggcaagcca ccgaaccggc gccgccccaa aagtcacccg cggccaacac atcacgaacg
2626081 atggcctgat gctccgcctc cagcaacccg gcctgagcgc ggatcatggc gccatgagcg
2626141 tcgacatcac cgaactgata gttgatggtc atcgaacctg ttctccttcg cttgtaaaag
2626201 tattgtgctg cagcggctga cgttagctgc tgaggatctg ctgggaggcc tgctcttgct
2626261 gctcgtagtt gttggcgtcg cgaaccagcc cgtcacgcac cccgtgcagc atgttcacga
2626321 tgttgcgaaa cgcctgattc atctgggcca tggtgtctag cgaggtcgcc tcggccatgc
2626381 cactccagcc cgcgcccgag atgttttgcg cggacgccca catccggcga gcctcgtcct
2626441 ccaccgtctg ggcgtgcacc tcaaaacggc ccgccatgtc ccgcatcgcg tgcggatccg
2626501 tcataaaacg tgttgccatg ttgcctgtct ccttgttgaa cctggaccta atacctgtaa
2626561 cttgtcatgc acattgactg ttgtcatagc cggccgcggg aacaccgaga ccgccgatca
2626621 ctggtcaaat aacgacagtc tgcgccccct ctcctagccg gccgccggag aatgcggaat
2626681 cacgctgctg ctactccgtg gcacctcaaa gcggggttca gcgttctccg ccacccactc
2626741 gttccacgcc tgccactcat cccactcgtc catggccgcg gcctctgcgt ccgccccttc
2626801 ggccgcctgg acatcgacat cggcgccgtc ctccggcgca ggcgcccagt ggtcataatc
2626861 atcgggtggc acagccactc cccagctgag cggaaccgac aacccgccga gcattcccga
2626921 ctcagcccgt ttcgccacca ccgcgtcggg cggcaaaggc ggaccaagag gcaaaagcac
2626981 gttgtcccct tccaggccag ggtctcaaca catccacact caatggctaa acacgaacca
2627041 ccaagcactc agcatcgtat gacaatccgc ggacaatatc ccgggttttc taatttcgct
2627101 gccatgagcc cgtccagcgg ccctggcgcg ggtttcgacc tagccaaccg ttacgtctga
2627161 accatccccg gctagcagat gccgctggga atcggccgcg cgggaccgga ttcctggact
2627221 ggcgttgttt gggggtaggg cacccgatac ggcaggcctt cgttcaagaa acccagcacc
2627281 acattgggca cgcacttggc gaccttcggc aattgacgga ccgggtggtc cagattgggt
2627341 ggcgacgggt ccggcggggc cgcgaaattg aatgccgacg tcatatcgcc ggtgacactg
2627401 gcacgccagg gtgtcaagtt gggaaccggc accccgaaac gcttgccgat caattgcagc
2627461 tgcgatgtgt ggtcgaaccg atcatggacc atcagcccgc cgcgactgta aggcgaaatg
2627521 acgaagcagg gcacgcgaaa gcccaagccg atgggtccac gtattccgcc ggagccgtcg
2627581 accttgtcga tgtcaacact gttgggaatc cattcgccgg gtgtgccctc cggcgcggtg
2627641 agcggtgtga cgtggtcgaa gaagccgcca tgttcgtcat aggcgatgat caacgcggtt
2627701 ttctcccaca ccgccggatt gcgcagcaac acccttatca agttcacgat cgtcaccgca
2627761 ccgactgcca ccgggaatga cggatgttcg gactcgacgg tcaacggaac gacccaggac
2627821 acctggggca gcgtgttgtt gatgacgtcg cggatgaaat cccacgggta ggccggggcg
2627881 atgccataac gggccaggtc cgacctcgga tctgcggcct gtttgaaact gcccacatac
2627941 ccgttacggc tcaaggaagt gtcgttgagc ccgccgagca gcttgctgtt gtacaccttc
2628001 caactgatgc cggcgtcact gaggttctgc ggcatgatgc gccaggtgaa ggtcaacttc
2628061 ggctggatgg cgggttcgac gatctgcggc ccaccttgat ccccgtcggg attgacggtg
2628121 gcgctgatcc aatagagccg gttaggcatc gtcccgccaa gaagcgacga gaagtactgg
2628181 tcgcagatcg tgaaggtatc ggccaacaag tagtggatcg gtatgtcagg acgtgcgtaa
2628241 tagcccatca ccacgggcgt gttggccacc gaccgggtcc gcgcctgcgc cggcagccag
2628301 ccgtcattgg cgccgccgtt ccatgacaag tgcgcggcaa tccactggtg gtctgggtcg
2628361 ttgacgcact cgccaacccc gttgggaccc ccggtggtat tgatgcggta gggcagcgta
2628421 atgccggtgg ggtccagcgc ctgcgtctcc gggttccagc ccttttgttg aaacagcggc
2628481 gtcggagtgt cgaacccgtc gacggcagaa agcgtgccga aatagtgatc gaacgacctg
2628541 ttctcctgta ggcacagcac gatgtgctcg atatcggtca aatgacccga gcagggaccg
2628601 gcaccatagg ccttttcgat caccggtgcg gcccagtccg tcaaaaccgc cgctgccccg
2628661 gctccagccg ccttagccag gaatgctcgg cgtgacattc cggcgaatgc accttggctc
2628721 accacatcgg ctctccctcg tgtatttcgg cttaccgtcg cggccatcgc cgactgtggg
2628781 tcaacagaga ccgctgggaa tcccccgagt gggtgcggtt tcttgggtgg gcatcgactg
2628841 tgggaatggc acccgatagg gaattgccgt cttggtcacc gttcccagta ctgcgttggg
2628901 cacgcactgc ggcaacttcg gaagcgcatt gagccgcggg tggtccagat tgggtttcga
2628961 cgggttcggc ggagcggcga agttgaacgt cgaagtcata tcgccgaccg tcgcgtcccg
2629021 ccaagcggtg agattgggaa ccgggacgcc gaaccgcgcg cggatgagct tcagcgttga
2629081 cgtgtgatcg aaggtgtcgt ggaccatcag tgggccgcgg ctatagggag agatgacgag
2629141 gcaagggacg cgaaacccca gaccgatcgg cccacgaatg ccacccgagc cgggcaccga
2629201 gtcgatgtcg gggaccgtga cgaattcgcc gggcgtcccc ggcggcggtg tcggcggcac
2629261 gacgtggtcg aagaacccgc cgttctcgtc gtagttgacg atcagcgcgg tcttttccca
2629321 caccgcaggg ttggacagca agatccgcag tgcatcgaca attgcaacgg cgccgacgtt
2629381 caccgggaat gcgggatgtt cggacagcag aaacccgggc agcacccagg agaccttggg
2629441 taatcggttg tttctgacgt cggcggcgaa gtccagcggg taggtcggtg agatgccgaa
2629501 acgggccaga ttcgacctcg gatccgcggc ctgcttgaag tcattgacca gcccgttgta
2629561 gccgacgacg gtgttgttga gagcccccag caatttgttt tggtacacct tccagctgac
2629621 cccggcatct tcgaggttct ccggcatgat gcgccagctg tagtgctgca gaggttggat
2629681 attgggctcg atcagcaccg gcccgccgtc agtgccgtcg gggtcgatcc aggcgctcat
2629741 ccagtagagc cggttgggcg tggtcccgcc cagcagcgag caaaaatagc cgtcgcagac
2629801 cgtgaacgtg tcggctagca ggtagtgaat gggcaggtca cgacgcgtgt agaaacccat
2629861 cgtgaccggc acgttgccct gcaacggact gaacgggacc tgcgccggca gccagttgtc
2629921 gttggcgccg ccgttccacg agttgtgcat gccgatccag ctgtggtccg ggtcgttgac
2629981 gcattcgccg gcgaccagcg ggccccgggt ggtgtcgaag cgatatggaa gggtgacgcc
2630041 ggcggggtca accgcctgtg tcatcgggtt ccagcccgac tgcgcgaata ccaccggcgg
2630101 ggtggtgtca tcgaacccgc gggtgtcaga aagagtgccg aagtagtgat cgaatgaccg
2630161 attctcctgc atcaacaaca cgatgtgctc gatgtcggtc aaatgtccgg ggcaaggccc
2630221 cgctccgtag gctttttcga taatcggacc agccaaggac atgaaggccc cggcggtggt
2630281 agcggcggcg gctttggcaa aaaattgtcg gcgggtcatt ccgtcgacgg ggtgttcgct
2630341 ccccacgcgc cctccttgac ggcccacacg gccattgctg atcacggtat agttgcggcc
2630401 gcgatcggct atgccttgcc gaccggcgtg tcgtgttctg attccgcctg cctgccgggg
2630461 cgggcgcggg attggtgcgg gcgatttgct cgcgcacatg caagcaaatc gaacgccggg
2630521 agattaccgg gaaatttcag ctgcacagcc cgctgggagt cccgcggacg ggtgtggttt
2630581 cctgagttgg catcacctgc ggatagggca cccgataggg aatgctcggc aacgcgccgt
2630641 cggtggttcc caacaccacg ttagggatgc actgcggcag cttcggcagc gctcccagca
2630701 acgggtggct caagttgggt ctggtcgaat tcggtggagt cgcaaagttg aacgctgagg
2630761 tcatgtcgcc aaccacgccg tcgcgccagg cggtcatgtt gggaaccggc acgccgaacc
2630821 gggcgcgaat caacttcaat tgcgaggtgt ggtcgaacgt gtcggagacc atcagcgggc
2630881 cgcggctgta cggcgaaatg acaatgcagg gaacgcgaaa acccagaccg agcggaccac
2630941 gaatgccacc ggacccgggt actgcgtcga tgttgggcac cgtgacgaat tcgccgggtg
2631001 tcccgggcgg tgccgtgggg ggcgtgacgt ggtcgaagaa gccgccgttc tcgtcatagc
2631061 tgacgataag tgcggtcttt tcccacaccg cgggattgga cagcaagatc cgcagcgcgg
2631121 tcaccatgga caccgcgcca agcgctaccg gcagggcggg gtgttcggac tgcaggatgt
2631181 tgggaactaa ccaggagacc ttgggtagcc ggttggccct gacgtcggca gcgaagtccc
2631241 cagggtaggt cggggcgata ccgtagcggg ccaagttcga cctcggatca gctgcctggc
2631301 ggaaggcctg caccagcccg ttattgctga tgggcgtgtt gatgaatcgc ccgaggccct
2631361 tgttctggta caccttccag ctgaccccgg catcttcgag gttttccggc atgatgcgcc
2631421 aactgaattg ctgcagcggc aggaagcccg gctctaccaa ttggggtccc ccgtcggtgc
2631481 cggcggggtc gatgttggcg ctcaaccagt agagccggtt gggcagggtg cccgtcagca
2631541 gcgagcaatg gtagccgtcg cagatggtga acgtgtcggc cagcagatag tggatcggga
2631601 tgtcttggcg cgtgtagtaa cccatggtca aagggacata tggtcctgcg cgggtggtcg
2631661 cctgcgccgg cagccagttg tcgttggcac caccgttcca ggccaggtgc atccccaccc
2631721 actggtgctc ggggtcgttg acgcactcgc cgtccaggaa ggggcctcgg gtggtgtcca
2631781 agcggaacgg aatggtgacc ccggcggggt ccaacgcctg cgtcatgggg ttccaaccca
2631841 tttgttggaa tgccggcgac gcggcgttga acccattggt gctggaaagc gttccgaaat
2631901 agtggtcgaa tgaccggttc tcctgcatca gcaacacgat atgctcgatg tcggtcaaat
2631961 gtccgggaca aggcccggcg ccgtaggcct tttcaatcac cggtgcagcc cagtccatca
2632021 ggaatgccgc tgcgcctgcg ccagtgagct ttgtcaaaaa ctctcgacgt gacattccga
2632081 ggagtgggct tgcgctcact tgccctgcct tcctgcactc agctcagatc acgttatagt
2632141 gacgacagcg gtccatcgcg atacgccaac cggcgtgtcg cacgcggatt ttcgcgttcc
2632201 agcaaccgca accgcaccgt ttggcgcggc cgacggccgt ctaggggata tcgcagcggg
2632261 aagggtgccg taaccatgat tgtcgctggg tatcgggcac tcgccgacag taaaaaatta
2632321 ttcgaatccc gcattcctga caaaacttga tatgaccgat ctcaccggcc ggcttcggcg
2632381 cttaagtcac tagacagttc gaggtcagcg acgggatatc gcgctatcgg taaactaatt
2632441 tcgtatctgc ccaaccgcgc cgccaatgca gcgtccgtac catgtggact acggtgctga
2632501 tgttgactct ggtggcgacg gctgacaccg tccggatccg aactggcgtt cttttgtccg
2632561 cccattgctt gcattctggc tccggggcat agcgacaagt gttgccctgg ctgttgacgt
2632621 gctcttcggg caagcggact tcacgctttc aagcgtgcac tcggccgaac ttgccagcgc
2632681 gaactccacc agcggacacc ttcagatcgc gatggttgtg ctggcgctgc tgatcgccgg
2632741 gctcacggcc ggaggggctt tccgcatggc cagcggactg ggccacgcct aaagacttag
2632801 ctctctttcg cgagcgcgac cgcttcggtg cacttcattt cgccgacaat cacggcacca
2632861 aggccaggga tttccaacga cgtcgccgcc gcgatgactc ccgcgtcgac gcgccctgcg
2632921 cgctatccga tcccgacccg cggcaccaca ctgggccgag cctgcaccac atgcggattt
2632981 gcgccaccgc ggcccatcat cccggccggc atacccgccc cagcaccccc catacccatc
2633041 ggcatcggca tcatccccat gggcccgcct gccgccggca cctcagcagg catagccccc
2633101 aaacccgcca tcgccgaact ggccatccgc gcaggaaccg acccctccca ggtcggaggc
2633161 accgacatcg cccccaccaa ccgcgcctta cccaactccg ccgacatccc cgcacccaga
2633221 ccaccggcac cacctaggcc cgtccccgaa gcgatatcac cggcaaacgt cggcacatcc
2633281 gccgcagcca accccgcagc ctccgcaccg gccaacccag ccgtgttggc cgtagtcccc
2633341 atctgcgcca actgcatcat cggcccaatc aacatactgg ccggatacgc cgcggcctgc
2633401 cccacctgca gcgccgcatc caccggcaac cccgccgcca ccgactgcgc cgcagccacc
2633461 acagccggca ccccctccac cgcaccctcc gcgatcggag acaacgcagc cgaaaccgac
2633521 gtcgccatcc cggtcaactg cgcaccggcc tgggaagcca accccgccaa atccagcggc
2633581 ggcacactaa acggcgtcaa cgtctcagcc accgccgccg cccccgcgtg ataccccacc
2633641 atcgcaccca cgtcctgagc ccacatctcc acataatcga actcagtggc cgcaatcgcc
2633701 ggcgtgttct gacccaaaat gttcgtcgcc accaacgccc ccaacaacac ccgattcgcc
2633761 gtcaccgccg ccggatgcac cgtggccgcc aacgccgcct caaacgccgt cgccgccgcg
2633821 gtagcctgac cagccgacaa ctccgcctgc ccggccgccg cactcaacca ccccacatac
2633881 ggcgccgccg cccccgccat cgccaccgac gccggacccg accacggccc agccgccaac
2633941 ccggcgatca ccgcatcaaa cgaggacgcc gaggcccgca aatccgcagc caacccctcc
2634001 cacgccgccg ccgccataaa caacggcccc gaccccgcac cggcatagat ccgcgccgag
2634061 ttgatctccg gcggcaacca cgaaaaatcc aaaatcatcg caaccccaaa ccagccagcc
2634121 gcctcaacgg ctccgcctac cactctccag acacaaacca gcccacgggc ggatggtaag
2634181 acaatccaca ccgaaaatcc gcacttttac caaaacttta ttcatgaatt cggcatgagc
2634241 cgttcacgcc ggcacgtcac cgccgccagc caccgggcaa gtgtctagta actggacacc
2634301 ggaaggcagc caccgggcag gcctcgccgc aatccgcagc tacacggctc gcgatatttc
2634361 cgggccagag ttttagccac cgcgagccat cagcaactcg cgtaaagact gcgcgaagcc
2634421 aacgaaaaaa taaggcggca aaaatatccc gtcagacggt cacgtcatac cgagtgaggt
2634481 aaccgtgatt agaccaacta catcgcacta ccgaacggaa accaccacta tccgaacaag
2634541 ttcttgaaga aacccgaaag cccattgccg ctgaccagca ggcccgagtt gcccgtccca
2634601 aaattgaaaa atcccgaact catcacgccg gtcacaaaaa tcccggtgtt gttgacggcc
2634661 gcgttataga aacctgagtt gccgtagccc gtgttgagca cccctgagtt accgccgaac
2634721 atgcttgtgg tgctggtatt gacatagccc gagttgccga agcccgagtt ctgaatgccc
2634781 gagttgccac tgccagccgg gtcgttgtgc ccgaaaccag agttaccggt accggcgttg
2634841 aagaagcccg aattcggacc agcttgggtc atcgcgctga agaagcccgt gttgagcgtg
2634901 cccggattaa acccaccagt attgatgttg cccgagttcc ctaagccagt gttgacatca
2634961 cccgcattgc ccacaccgga gttgacgtcg ccagcattga ggaaaccact gttgccgtca
2635021 cccgaattcc caaaactcga gtttatgttt ccggcgttaa gactgccgaa gttgtagttg
2635081 ccagcgtcga aaaagcctgt gttgccggcg ccggcgttag cgaggccagt gtttgtgctg
2635141 ccgccgttcc aaaatccggt gttgacgttg cccgcgttcc cgaatccagt gttcgcagta
2635201 ccggagttcc cgaagcctac gttgccggtg ccggagttga acaaaccgac gtttccggtg
2635261 ccggagttcc cgaaaccgat gtttccgctg cccgagttca gtccgccgat gccgatctga
2635321 ccatcgccgg tgagcccgat accgatgttg ttgttgcccg tgtttccgaa accgaaattc
2635381 ccgctgccgg tgtttccgaa gccgatgttg ttactgccgg tattgccgct accaaagttg
2635441 aagttgccgt tgtttccgtt accgaagttc gtgtcgccga tgttgccgct gcccacgttg
2635501 gtgctgccga tgttgccgct gcccacgttg gtgctgccga tgttgccgct acccaggttt
2635561 tggctaccga agtttctgaa ccgccccggc atgtccggag actccagttc ttggaaagga
2635621 tggggtcatg tcaggtggtt catcgaggag gtacccgccg gagctgcgtg agcgggcggt
2635681 gcggatggtc gcagagatcc gcggtcagca cgattcggag tgggcagcga tcagtgaggt
2635741 cgcccgtcta cttggtgttg gctgcgcgga gacggtgcgt aagtgggtgc gccaggcgca
2635801 ggtcgatgcc ggcgcacggc ccgggaccac gaccgaagaa tccgctgagc tgaagcgctt
2635861 gcggcgggac aacgccgaat tgcgaagggc gaacgcgatt ttaaagaccg cgtcggcttt
2635921 cttcgcggcc gagctcgacc ggccagcacg ctaattaccc ggttcatcgc cgatcatcag
2635981 ggccaccgcg agggccccga tggtttgcgg tggggtgtcg agtcgatctg cacacagctg
2636041 accgagctgg gtgtgccgat cgccccatcg acctactacg accacatcaa ccgggagccc
2636101 agccgccgcg agctgcgcga tggcgaactc aaggagcaca tcagccgcgt ccacgccgcc
2636161 aactacggtg tttacggtgc ccgcaaagtg tggctaaccc tgaaccgtga gggcatcgag
2636221 gtggccagat gcaccgtcga acggctgatg accaaactcg gcctgtccgg gaccacccgc
2636281 ggcaaagccc gcaggaccac gatcgctgat ccggccacag cccgtcccgc cgatctcgtc
2636341 cagcgccgct tcggaccacc agcacctaac cggctgtggg tagcagacct cacctatgtg
2636401 tcgacctggg cagggttcgc ctacgtggcc tttgtcaccg acgcctacgc tcgcaggatc
2636461 ctgggctggc gggtcgcttc cacgatggcc acctccatgg tcctcgacgc gatcgagcaa
2636521 gccatctgga cccgccaaca agaaggcgta ctcgacctga aagacgttat ccaccatacg
2636581 gataggggat ctcagtacac atcgatccgg ttcagcgagc ggctcgccga ggcaggcatc
2636641 caaccgtcgg tcggagcggt cggaagctcc tatgacaatg cactagccga gacgatcaac
2636701 ggcctataca agaccgagct gatcaaaccc ggcaagccct ggcggtccat cgaggatgtc
2636761 gagttggcca ccgcgcgctg ggtcgactgg ttcaaccatc gccgcctcta ccagtactgc
2636821 ggcgacgtcc cgccggtcga actcgaggct gcctactacg ctcaacgcca gagaccagcc
2636881 gccggctgag gtctcagatc agagagtctc cggactcacc ggggcggttc aacaccgaaa
2636941 aattcaccac taccgcccct cctctaacaa atcattctca accgcacccc cgcgcgttac
2637001 cccaaacgac acgcggacac ccgtcaccga gacgtcctac gttgtctggg cgccaaaccg
2637061 gctcgatccc cgacttggct cacgattcgc ggctcagcat taatagagcc cgttgacctg
2637121 tgagtttgct tggtgacggg tcgaaaattg tgcacttgat gcactcagga gtacctggac
2637181 gcccggacgg ccaaccgggg cgccgccgaa ccacggtggc gcgccagatg actcaattga
2637241 cccgagtgct gctcccgctg tccgtaccgc tctttcgtca cgtccgcaac actggccctc
2637301 gccgtcggcg atggtcgctg tgcccacctt agcgcgacaa ctcggtttct gcaggtcaac
2637361 gcccgcctcc aatcccgcac agccacgacc aactcgggaa caaaaccgcc ggtcaggcag
2637421 ctgtcgctga gagccgggca catcgggtgt cgcccggtac agtgacacat gtgaccgttg
2637481 cgaccgtgcg atgtgcccga cgctcgatgc gcaccaattc gaaccaactc aggtcttacg
2637541 ctgcctggac gccgaactag ctcgatccag cgccgacccg caccccacta ccggcatctg
2637601 aaggtgagcc agagacgcgt cgaccaggaa gaaccgtggc cgcacgggtc acccgggcac
2637661 acccaaccgg gccgtggcaa gtgccgacta cctgaagaat cccgaaagtc ctacacccgc
2637721 attgaaagca ccggagttct ggctacccga atttaccgca cccgaactgt cgtcacccga
2637781 gttggagata ccggcgaggt tgttacccga gtttgcaatt cctgcattga aagagccaat
2637841 gtttgcaaac ccggagttga agccaggaag catggctggg ccggcgttgg agaagcccga
2637901 attaccgttg cctgtgttga agaacccgga gttgccggtg cccgaggggt cactgttccc
2637961 ccaacccgag ttgccggtac cgaggttccc gaagcccgag ttggcacctg cttgggtgag
2638021 cgcgctgcca aaaccggtgt tgacgttgcc gccattgaaa ccaccggtgt tgatatctcc
2638081 accgttaaag aaaccggtgt tgacgttacc tgcgttcgcg aaaccggtgt tcgagtcacc
2638141 cgcattgaag aagccggtgt ttccagcacc cgaatttccg aagccggtgt tctgaaagcc
2638201 cacgttgaag ctgcccgagt ttgagttccc gccgtcgaag ataccgacgt ttccgttgcc
2638261 ggcactcccg aagcccgtgt ttaaattgcc tgcgttccag aaaccggtgt tgatatttcc
2638321 ggcgttcccg aaacccgtgt tgccgtcacc cgagttgaag aagccgatgt ttccatcacc
2638381 cgagttgaag aagccgatgt tgttgttgcc ggagtttccg aagccgatgt ttccagtgcc
2638441 tgagttcagt ccgccgatgc cgatctgacc atcaccggtg agcccgatac cgatattgtt
2638501 gttgcccgtg tttccgaaac cgaaattccc gctgccggtg tttccgaacc caaagttgag
2638561 ggtgccatta ttcccgccgc caaagttgaa gtcgccggtg ttcccgccgc cgaaattgac
2638621 atcaccgtta tttccgttgg cgaggttgag cgtgccgaag tttccgctgc ccacattgag
2638681 gctgccgata tttccgctgc cgaagtttcc gctgccgaag tttccgctgc cagggttgta
2638741 gtcacccgtg tttccgctgc cggcattgcc ggtaccggtg tttccgctgc cccagttcag
2638801 gctgccgtag ttcccgctgc ccaggttggt gccgccgaca ttgccactgc ccacgttggt
2638861 accgccgatg ttgccgctgc ccaggttgag gctgccgatg ttgccgacac ccaaattcaa
2638921 ggtcagctcg gcgaggcctt gtgcagcgcc ttgtgcagcg gccgccggtg cgttagccgc
2638981 accgcctagc aagcccgaca agcccggcac cgcctgctgc catggcgcca acgccgccgc
2639041 cgccgccgat gccccaccgt gataacccac catcgccgcc acatcggcag cccacatctg
2639101 ctcataggtg gcctcagcag cggcaatcgc cggcgcattc tgcccaaaca cattcgacag
2639161 caccaactgc acaaacgcac tgcgattagc cgccaccacc accggatcca ccatggccgc
2639221 ccgcgccgcc tcaaacgcgc cggccaccgc cttagcctga accgcagccc ccccagcccg
2639281 cgccgccgca gcagccaacc accccgcata cggcgccgcc gccaccacca tcgccgccgc
2639341 cgccgcaccc tgccacgcct gacccgaccc acccgccaga cccgaggtca ccaacccaaa
2639401 cgactccgcc gccaacccca actcagccgc caacccatcc caggccgccg ccgccgccaa
2639461 catcggcccc gaccccgcac caaaaaacat ccgccccgaa ttaatctccg gcggcaacac
2639521 cgaaaaattc accactaccg cccctcctct aacaaatcat tctcaaccgc acccccgcgc
2639581 gttaccccaa acgacacgcg gacacccgtc accacggcgc cgcccaccca gcggccacca
2639641 cagctcaccg ggtcgtgccc ggaccggggc tgctagctgc ccttgagccg caccgcgaga
2639701 tagtcggcca cgctgctcat cgcaacccgg tcctgcgtca tggcgtcacg ctcccgcacg
2639761 gtgacggcat tgtcctgcag cgagtcgaag tcaaccgtca cacagaacgg ggtaccgacc
2639821 tcgtcctggc gccggtaacg ccgcccgata gcgccggcat catcgaaatc gatgttccag
2639881 catttccgta attcggcgcc caggtcccgg gccttcgggc tcaggtccgc gtgccgggac
2639941 agcggcaaca ccgccgcctt gaccggcgcc agccgcgggt ccaatcgcag caccgtgcgc
2640001 ttatccatcc cacccttggt attcggggcc tcgtcctcgg tgtacgcgtc gatcaaaaac
2640061 gccatgaatg accgggtcaa gccagctgcc ggctcgatga cgtacggcgt gtaccgaaca
2640121 tcgttgatct ggtcgtagaa agacaggtcg acgccggaat gccgcgcatg cgtcgatagg
2640181 tcaaaatcgg ttcggttggc cacaccttcc agttcacccc atggattgcc catgaagccg
2640241 aacttgtact cgatgtcgac ggtgcggtcg gagtaatgtg acaacttgtc tttggggtgc
2640301 tcccacaacc gcaggttctc ccgacgaata cccaggtcga tataccactg cagccggttg
2640361 tcgatccagt actgatgcca ttccttggca gtcgccggct cgacgaagaa ctccatctcc
2640421 atctgctcga actcgcgggt ccggaagatg aagttgcccg gagtgatctc gttgcgaaag
2640481 ctcttgccga tctgtccgat accgaatggc ggcttcttac gagcagttgt caccacgttg
2640541 gcaaagttca cgaagatgcc ctgcgcggtt tccgggcgca gatagtgcag cccctcctcg
2640601 gtctcgatgg gtccgaggta ggtcttgagc atcatgttga actcgcgtgg ctgcgtccac
2640661 tggccgggtt cgccggtttc cgggtcgcga atgtcggcca acccgttagg cggcggatgc
2640721 ccgtgtttgg cttcgtaggc ctcgatgaga tggtcggccc ggtagcgctt atgtgtgatc
2640781 agcgactcga ccagcgggtc atgaaagaca tcgacgtgac cggaagccac ccacacctca
2640841 cgcggcagga tgatcgacga atcgattccg acaacgtcgt cgcggccagt caccaccgat
2640901 cgccaccact ggcgcttgat gttctctttg agctcaaccc ctagcggacc atagtcccac
2640961 gccgactttg tgccgccgta gatctcgccc gacggataga cgaagcctcg ccgtttggct
2641021 aggttgacca cggtgtcgat gacgggcgcc acggggtggt gcactccctt cgagggatcg
2641081 ggcagacgcg cgcagcccga cacgactacg cgcaaaacat cagtcatggt agcgatcggg
2641141 acctgggtct cctattgcct ttgacatgca tcatcatgca tgtgacagtg gaggtcagtg
2641201 gcaggtcctt cctaatacgg cacttctcga ggtgaagact ccaatatggt gacgtccccc
2641261 tcaacgccga ccgccgccca cgaagatgtg ggtgccgacg aagtaggcgg tcaccagcat
2641321 cccgcggata ggttcgccga atgccccacg ttccccgcac caccgccgcg ggagatccta
2641381 gacgctgccg gcgagctgct gcgtgcgctg gccgcaccgg tgcggatcgc catcgtgctg
2641441 caattgcgtg aatctcaacg ctgcgtgcac gaactggtcg acgcactgca cgtgccccag
2641501 ccgttggtca gccaacatct gaagatcctc aaggcggcgg gcgtggtcac cggggagcga
2641561 tcgggccgag aagtgctgta ccgacttgct gaccaccacc tcgcgcacat tgtgctcgac
2641621 gccgtcgcgc acgccggtga ggacgcaata tgagtgcagc cggtgtccgc tctacccgcc
2641681 agcgggcagc catctcgaca ctgttagaga cgctcgacga ctttcgttcg gcccaggaac
2641741 tgcacgacga actgcgccgg cgcggcgaga acatcggtct gaccaccgtc taccgcacac
2641801 tgcagtcgat ggcatcctcc ggactggtgg acacactgca caccgacacc ggtgaatcgg
2641861 tctaccgcag atgctcggag caccatcacc accatctggt gtgccgcagc tgcggttcca
2641921 ccatcgaagt aggtgaccac gaggtggagg cgtgggcggc ggaggtggcc accaaacatg
2641981 gattctctga cgtcagccac accatcgaga tcttcggcac ctgctcagac tgccggagct
2642041 aggacaccac cgaggtcgag cgaccccaca cgccgaacgt gcaaccatgg cggctccgcc
2642101 cggcgtgtcg ccgccaccag ggcacgttcg gcgcacagcg agcacactcc tagccaacga
2642161 gcgcgctgcg gatcgtggcg cccgtctcca gcaccaaaag gatcaacgtg cgcaacgcgt
2642221 cgtcggtcaa accggtgccg ggaaagttgt atcgcagcat cacgtccgcg gtgttggacg
2642281 cgggccgacc agagcttcgc cgcgcagcct tctcgctgac cttttcccgc aggctcaccg
2642341 agccgaagtt gatgtcgcgt gcctgcttgg ccacttgctc ggcgagcctc ttggtcaacg
2642401 gcagatccca cgccaggatc tgggtaaggg acaccagctc gaggtcctca gcgatgctca
2642461 ctacccgcaa cgaggcaaac gtaccgtcat ggcgaaccgt cagcgcgccg tcgggttcct
2642521 cctcggcagg aaggacatcg cgcagtatcg atgccagccg gtccggtagg gatggcacta
2642581 ggcgctcccg aaccgccgag tgcgcgacgc gtattcctcg caggccgccc acaagtcgcg
2642641 gcggtcatag tcgggccaga gcttgtcctg gaatatgtat tcagcgtagg ccgcctgcca
2642701 cagcatgaag ttgctggagc gctgctcacc cgaggtccgc aggaagaggt caacgtcggg
2642761 aatgtcgggt cgctgcaggt ggcgggcgat cgtggattcg gtgatccgct ccgggttgag
2642821 cctgcccgcg gcgacctcac gagcgatttc gcgggtggct tcggtgattt cggtgcgtcc
2642881 gccgtagttg acgcaatagt tgatggtgat gacgtcgttg cttttggtca tctcctccgc
2642941 gaccgccaac tcattgatga cgctacgcca cagccgtggt cgtgaaccca cccaccggat
2643001 ccggacccct agcttcttta gggtgtctcg gcgccgtcgc accacgtcgc ggttgaagcc
2643061 catcaggaag cggacttcct cgggcgaacg cttccagttc tccgtggaga aggcgtagag
2643121 gctgagccac ttgatcccaa gttcgatagc accgcaagcg atgtcgatca ccaccgcctc
2643181 gcccatcttg tgaccttcgg tgcgggccag cccacgttgg gtggcccagc ggccattgcc
2643241 gtccatgaca atggcgacat ggttgggcag ccggtcggcc ggtattcgtg gcgcggccgc
2643301 tttcgaagtg tgctgcggtg gccggcaggg gcctccgtag ggcgctgccg gcaactccgg
2643361 gaagacgacg ggccacgtcg acgtatcagg aaaggtcggg tagtcgtcgg gggccggagg
2643421 cagctgcggg aagttgctgg acgtccgctt ccgtgcatcc ctagccaccg gctatatcct
2643481 gcccgatcag cgcggcgcga cgttcggcaa ccgatcgatc ggcctggtag aaccgctcca
2643541 ccagcggcaa cgttttcagc tgccgttcca gatgccattg caggtgtgcg gccaccaacc
2643601 cgctgacatg gctgcgggcc gattgcggcg ccgcctcggc ggcctcccaa tcgccgtcgt
2643661 acagcgcgga catcaggtct acgacgccca gcggcggtgt ggtcgagccg gccggacggc
2643721 agtgtgcgca gacactgccc ccggtcgcga tgtgaaacgc ccgatgcgga ccaggcgtgg
2643781 cgcagcgggc gcactcggtc aacgctggtg cccagccggc gatgcccatg gcgcgcagca
2643841 gataggcgtc caacaacagg tcccgaggcc gctgtccatc ggccaccgcc cgcagcgcgc
2643901 ccaccgtgag ccggtgcaga gccggagcgg gcgcccgctc ctcaccggcc aggcgttcgg
2643961 cggtttccag tatcgcgcat ccgcaggtgt agcggccgta atcggcgacg atgtcggtgg
2644021 cgaacgcgtc gacagagaca acctgggtga cgatgtcgag gttgcggcca gggtgcagtt
2644081 gcacctcgat atgcgcgaac ggctccaggc gcgcgccgaa tttgctgcgg gtgcgtcgaa
2644141 cacctttggc caccgcgcgg accaacccgt gatcgcgggt cagcagggtg acgatccggt
2644201 cggcttcgcc gagcttgtgc tggcgcagca caacagcccg gtcccgatac agccgcatca
2644261 caatagtttt gcaccccgcc acgacatcgc gggtatccgc gccgatagtc tcgtaccccg
2644321 tggttggcgc ttctgggtcg gatgctggag ccatttccgg ctctggcaac cagcgcctgc
2644381 ccaccctgac cgacctgctc taccagctgg ccacccgcgc agtgacgtcc gaagagttgg
2644441 tgcgacgttc cctgcgcgcg atcgatgtga gccagcccac attgaacgcc ttccgggtag
2644501 tgctcaccga atccgcgctg gccgacgcgg cggccgccga taagcggcgg gcggccggcg
2644561 acacggcgcc gctgctgggc attccgatcg cggtcaagga cgacgtcgac gttgctggag
2644621 tgccaaccgc cttcggcacc cagggctatg tcgcgcctgc taccgacgac tgtgaggtcg
2644681 tccggcgcct caaggcggcc ggagcggtga tcgtcggcaa gacgaatact tgtgaattgg
2644741 gccagtggcc gttcaccagc ggacccgggt tcggacacac ccgcaacccc tggtcgcgcc
2644801 ggcacacgcc gggtggatcc tcgggcggta gcgcggcggc ggtggccgcc ggcctggtta
2644861 ccgccgctat cggctccgac ggcgccggca gcatccgcat ccccgcagca tggacacacc
2644921 tagtgggcat caagccacaa cgcggtcgga tctccacctg gccgctgccg gaggcgttca
2644981 acggcgtcac ggtcaacggc gtactggccc gcactgtgga ggatgcggcg ctggtgctgg
2645041 acgccgcgtc cggcaacgtc gagggcgacc gccaccagcc acccccggtg acggtgtccg
2645101 atttcgtcgg catcgcccct ggaccgctga agattgcctt gtcaacccac ttcccgtaca
2645161 ccggctttcg ggccaagttg catcctgaga tcttggccgc gacccagagg gtgggcgacc
2645221 agctcgagct gctcggccat acggtggtga aaggcaatcc ggactacggc ctacggttgt
2645281 cgtggaactt tcttgcccgg tccaccgcgg gcctctggga atgggcggag cggctaggcg
2645341 acgaggtgac cctggatcgt cgcaccgtat ccaacctgcg catggggcac gtgctgtcgc
2645401 aggcgattct gcgcagcgcg cgccgccacg aagccgccga ccagcgtcgg gtcggctcga
2645461 tcttcgacat cgtcgacgtg gtgctggcac cgaccacagc acaaccaccg ccaatggcgc
2645521 gcgcgtttga ccggttgggc agcttcggca ccgatcgcgc catcatcgcc gcgtgcccgt
2645581 cgacctggcc gtggaacctg ctgggctggc cgtcgatcaa tgtgccggcg gggttcacct
2645641 ccgacggttt gccgatcggt gtgcaactga tgggaccggc caacagcgag ggcatgctga
2645701 tctcgctggc cgccgagttg gaagccgtca gtggctgggc gaccaagcag ccgcaggtgt
2645761 ggtggacgag ctaaaacccc agtcggccaa gctgtttggg gtcgcgctgc cagttcttgg
2645821 cgaccttgac ccgcaagtcg agatagacct tggtgcccag caggttttcg atctggctac
2645881 gggccgcggt acccacctcc cgcagccggg caccaccctt gccgatgacg atgcccttct
2645941 gactatctcg ctcgacgtac agcgcggcgt gtacgtcgat caggtcgtca cgcccctcac
2646001 gtggactgac ctcgtcaatc accaccgcca gcgaatgggg cagctcatcg cgcacgccct
2646061 gaagggccgc ctcgcggatg agctcggcca tcagaacctc ctcgggttcg tcagtcaact
2646121 caccgtcggg gtaatacgcg gggccggccg gcaatgccgc ggccagtacg tcgatcaaca
2646181 ggtctacccg gtcgccggtc atcgccgaaa ccgggacaat ctcggccgca ttcgtgacga
2646241 gttcgctgac cgctaccagc tgggcgacca ctttttcttt cggcaccttg tcaatcttgg
2646301 tgacgatgac caccagtgtc gtattggcag ggccggtcga acgaagctgc tcgacaatcc
2646361 accggtctcc cggaccgatc gcctcgtcgg cggggatgca tagcccgatg acgtcgaccg
2646421 ccgcgtaggt ttcgcggacc aagtcgttga gccgcttgcc cagcagagtg cgcggccggt
2646481 gcagaccggg agtgtcgacg aggatgatct ggaagtcgtc gctatgcacg atcccacgaa
2646541 tggcgtgcct ggtggtctgc gggcgcgtcg acgtgattgc cactttcgcc ccgaccagcg
2646601 cattggtcag cgtggacttg ccggtgttcg gccggccgac caaacacaca aagccagaat
2646661 ggaattcggt catgccggtt tcctcgccga acgtgaacac agggagactt ttcccgcttt
2646721 tttccgccgt gaatgcacgt tcggcgtcat agcgggttac ctgcccgatc ggtgacgatg
2646781 atcgcagcgg tcggggcgag ttcgcggacg gcggcaatgc ccggatcgtc aacggacccg
2646841 gccaccaaga cggcggcctg aagaccggtc gccccactgg acacggccgc ggccaccgcc
2646901 gcctgcagac cggtcagctc gagcgccgac agggccaccg gcgccgccgc gtacgtgcgg
2646961 ccgtcgacat cgcggaccgc cgcgccggca ccggcctcgg cacgtgccat cgccgcccgt
2647021 gccaacacaa ccagctttgc gtcctcggca tctagctgct cagccagggt gatcggcctc
2647081 ctcatcatcg gcgccgtcgg gttcggccgg actcagcaac acggtgccga ttcgtacccg
2647141 tccccgatga tcggtgccac cctcggcatg cagccgcagg ccatgcgata tcacctcagc
2647201 gccgggcagc ggcacccggc ccagttctag ggccagcagc ccgcccaccg tgtcgacgtc
2647261 aaggtcgtcg tcgaactcca cgccgtacag ctcgccgacg tcttcgatgg gcaggcgcgc
2647321 cgatacccgg aaacgcttgt cgcccaagtc ttccaccggc gccgtctcgg cctggtcgta
2647381 ctcgtcggca atctcgccga cgatctcctc cagcacgtct tcgatgctga cgaggccggc
2647441 tatcgcgccg tactcgtcga ccagcagggc catgtggtta cggtcgcgct gcatttcccg
2647501 cagcaatgcg tccagcggct tggagtccgg cacgaacaca gctggccgca tcacccgcgc
2647561 gacggtcgtt tcgcggccgc cgttcgtcga gcagaacgtc tgctcgacaa ggtctttcag
2647621 gtacaccacg ccgacgatgt cgtcgacgtt ctcgccgatc accgggattc gggaatgtcc
2647681 gctgcgtacc gccagggtca ttgcttgacc ggctgtcttg tcgctttcga tccagatcat
2647741 ctcggtgcgc ggcaccatca cctcgcgggc tggggtgtca cccagctcga agaccgactc
2647801 gatcatccgg cgctcgtcgg cagcaaccac gccccgctgc tgggctaggt cgacaacttc
2647861 gcgcagctcg atctcggatg caaacggccc gttgcgaaag ccgcgcccgg gggtcagtgc
2647921 gttgcccagc aacaccagca agcggctgat cggcatcaac aaccacgaga tcagccgcag
2647981 cggaagggcc gtggccaacg agatggaata tgcgttctgg cgcccaaggg tgcgtggccc
2648041 cactcccacg acgacaaagc tggccaaaac catgatgccc gcggcaagat acaaccccca
2648101 caccatgctg aagtggtatc ggatgaaaac caccagcagc gcggtcgcgg tgatctcaca
2648161 gctggtccgc agcaacacga ccaggttgac gtaccgcggc cggtcggcca tcaccttacg
2648221 cagcgacccc gcgcccggcc gctggtcgcg tactagctca tccacccggg ccggagacac
2648281 ggtgctgatg gcggcgtcaa tcgcggcgaa caacccaccc aaaccgatca atacgatcga
2648341 gccgagcagc tggtagtacc cggtcaaagg tcaaaatacc ttgacttgtc gagcaaccgg
2648401 cggtccttct cgtcctgccg gtcgtgctgg taggcctcaa cctggtcggc tacccactct
2648461 tcaagcaacc ggtcctgcag ggcgaacatc tctttttcct cgtctggctc ggcgtggtca
2648521 tagccgagca ggtgaagcac accgtggatg gtcagcaggg ccaattcgtg gcccaggctg
2648581 tggccggccg cagccgcctg ctcagcggcg aattccgggc acagcacgat atcgcccagc
2648641 atggacggtc ccggttcggg ggcgtcgggg cgaccacccg gctcgagctc gtccatcggg
2648701 aagctcatca cgtcggtcgg cccgggaaga tccatccagc gcatgtgtag gtcggccatc
2648761 gccgcggtgt ccagcagcag catcgacaat tcggcgcacg gattgacgtc catcttggcg
2648821 atgacaaacc gtgcgacact gactagttcc gcttccgaga cgtcgatgcc tgactcgttg
2648881 gctacctcga tgctcataag atgctcacgc acccatcatc ggcgaccgcg ggcgccggac
2648941 gcccgccgag ccgcccgatt cagccccgac ccgggctcct cgtaccgcgc ataagcgtcc
2649001 acgatctccg agaccagacg gtggcgtacc acatccacgc tggtcagctc cgcgatatgg
2649061 atgtcgtcga tgtcttcgag gatgtcgacc gccgcccgca gacccgaccg ggcgccgccc
2649121 ggcaggtcga tctgggtgac atctccggtg accacgacct tggatccgaa gcccaggcgg
2649181 gtgaggaaca tcttcatctg ctcggccgtg gtgttctgcg cctcgtccag gacgatgaac
2649241 gcgtcattca gggttctacc ccgcatgtac gccagcggtg ccacctcgat gactccagcg
2649301 gacatcagct tcgggatcag ctcggggtcc atcatgtcgt acagcgcgtc atagagcggt
2649361 cgtaggtacg gatcgatctt ttcgctcagc gtgcccggca gaaatccaag gcgttcaccg
2649421 gcttccaccg cgggtcgggt caagattatg cgggtcacct gcttggtctg cagcgcgtgg
2649481 accgctttgg ccatcgcaag ataggtcttt ccggtgccgg ccgggccgat tccgaagacg
2649541 atggtgttgg cgtcgatcgc gtccacgtag cgtttctggt tgagcgtctt gggccggatc
2649601 gtcttccccc gacgcgacaa aatgtctaga gtgagcactt cggccggtga ctcgttgcct
2649661 gtgccgacca gcatggcaac gctgtggcgc actacctctg gggtcagcga ctggccgctg
2649721 gccacgatcg caatcagttc ggagatcacc cgttcggcta gcgcgacatc cgccggctca
2649781 ccgcagaggg tcaccgcgtt gccgcgcacg tgcaggtcgg cactcagcgt gcgttcgagg
2649841 gcacgcagat tttcgtcggc cgaaccgagt aagcccacga cgaggtcagg cggaacgtcg
2649901 atgctgctgc gaacttgagc gtcggcttgc cgggctccag ccgcgtcagc agcgcgggtc
2649961 tcgcgggacg tcacctggct tctgatgcct gctttctggc ctatcgactg gaacctgtcg
2650021 aactgacgag tgttgaagtt tcattctaac gccggtcagg gacggcgtcg gagcacaacg
2650081 cacaacgccg agcccgtgcg cgctcacctt tatccgcgat gaggcctgtc tgtgtccgcc
2650141 cgttcgatgc cgacgaacgg cagccactct cgggcctgcc agctgtgcct gccggtgcgc
2650201 ggcaacatcc cgaccgtgcc catgccggtc cgccaagccg acgatcaccg ctcaagctgg
2650261 gccagccgtg agcgtcggcg ccccaatgat tcgggtggcg ggctagtaat cccttcgacg
2650321 ggggtttcca cggggtcgct ggtctgactg ccgcgccatt ggagggcgct gatggccacg
2650381 gcgacctgga tgatcgtgtg gtcgaggggt cggggtagga gtcgttgggc ggtttcgagt
2650441 cggcgtagca gggtgttgcg gtgggtgtgt agtacgtgcg cggcgcggga ggcgttgcat
2650501 tgttcgttga tgtaggtcaa tacggtggtg agcagttgag ggctggccga ttcgaggtcc
2650561 ccgagggtgc tggtgatgaa atcggctgcg ctgtccgggt tttcggtgag taccgcgatc
2650621 atgtggatgt cggcgaagaa agccaggcgc tgttgggatc gaagccgggc cagcatgcgt
2650681 tgggtggcca gggcgtcgcg gtggctgcgc cgaaacccgt cgattcctcg tgcggtggtc
2650741 ccgaccgcga tgcgggcatg tggtgcgtgg tcgagcacct ggtggattcg gtcggtgtcg
2650801 agggttgccg cgtcgctgac ccatacccag cgggtggccg cgctggcgac cgcgatcagg
2650861 ggctgtgggc atcccagtgc gcggccgaac gcgcgtgcgg tgtggtcgag gtggttttgg
2650921 ttgtcgtcgg gatcgtcata ccagatgatg gcggcggtgt gggatcggtc tagggggtag
2650981 cccagtttgg cttcggcgct ttggcggctg atgggggcgc cgtcgaggat cagttcgacg
2651041 atgcggcggt gttcggcgtg gacgtcgcgg gtcagttcgt cgtattcgag ctgcatttgt
2651101 gcggccaggc cggccagggt ggcgtcgatg aattcggagg ccgagcgaaa cggcagggtg
2651161 agcagttcgt gcagttcttg ggggtcggtg gtgagtccga acgcgatttc ggtccatcgt
2651221 tgccaggcga cgttttgtcc gacgcggtag acgtccagcg ctgaggcgtc tagtccgcgg
2651281 cgcaccaggt cgcgggccat gcgtagcggg tcggggccga ggtttgccgg tacgggttgg
2651341 ccgggtttgc gcaggttggc ggtggcgaag tggatcaggt gggagcggtt ggcgcggctg
2651401 accactgttg ctagggcggg gtcggcggcg atggatgggt gggcggcgag ggtggcgcgg
2651461 tcgagttcgt cgagccattc cggggtgggg tgcagggcga cttttgctgc ttggcggatg
2651521 agttcacgtc cgcgcggtgt gggtttgggc aataccacga gatgagacta gttgcctagg
2651581 tgcgttgtgc accacgttct ggggaatgtt ggtgaggttt actccttcag ccgtggtgga
2651641 cgtttagccg gtgtggcgcg ttcgggatta ttgggatgaa cggttaccca ccgcggcggc
2651701 agcgggccgt gcgcctgccg agtcgtcgac atttagcgtt caggaggtct cgatgtcgtt
2651761 ggtcagcgtg gccccggagt tggtggtgac ggcggtaccg gatgtggcgc gcatcgggtc
2651821 gtcgatcggt gcgcccgaca ccgcggcggc ggcgagaccg accaccagcg tgctggccgc
2651881 cggcgccgat gaggtgtcgg cggacgtcgt ggcgctcttt ggctgggtcg cccgttgatg
2651941 gtgatggggc cgctggggcg cccgagaccg ggcaacggcg gggccggcgg ctcgggtgcg
2652001 cccggccaag ccggcgagtg ggattctgac gaccggctac cggcgtgtca cgtcgcagta
2652061 ttcacagtcg ctcgctgatg catcccaacg agatgtgagc acaccgacag cacccaatgc
2652121 caccgcggcc gcggtcgatg tccgcagcac cgtcgggccc agccggaccg cgacggcgcc
2652181 ggcatcggtc agcgcggcaa gctcgtccgg tgcgatccca ccctcgggtc caaccacgag
2652241 catcaacgaa ccagcttgcg ccgcagcgat atccacaatc cgctcggtcg cctcctcgtg
2652301 caggaccagc accgccgcgc cggcggccac ctcttctcgg acacgctgta caagcattgg
2652361 cgtcgacaac acgccgtcga ccggcgggat gcgcgcccga cgagattgcc gggccgccga
2652421 gcggaccacc gctcgccacc gacgcaaacc cttgtcgaca cgcgccccgt cccagttcgc
2652481 cacgcagcgc gccgcctgcc atgccaggaa cgcgtcggct ccggcttcgg tggccagctc
2652541 gattgccaat tcggagcgtt cggatttggg cagcgcctgc accacggtca ccggtggccg
2652601 cacgggcggg acgctccagc gcctaagcac ccgggcccgc agcccgccac gtccggcctg
2652661 ctccaccaca cagcgggcca ggcgaccgac accgtcacca agcaccaact gctcgccggg
2652721 acggatccgc cgcacggtgg cggcgtgaaa tccttcgtcg ccgtctacga ccgccaccgc
2652781 accggtgtcg ggcagtgtgt cgacgtaaaa cagcatcgcc accatgtgcg ggccgtgatt
2652841 agcgcccggt gaaggtctcg cgcaaccggc tgaacagtcc gccggcggcg gcgtgggtcg
2652901 aacggacctc ggccacctcg cggtcgcggc gacccttcag ctcgcgcagc agttcgatgt
2652961 cctggtgatc cagccgggtc gggaccacca cctccacgtg aacgtgcagg tcgccacgcg
2653021 tgttggaacg caggtgcggc attcctcgac cgcgcagcgt gatcaccgaa cctggctgcg
2653081 tgccgggtgg aatggtgatc tcgctcaggc cgtccaggat ggcgtccacc gtgaccgtaa
2653141 cacccagcgc cgcgtcgacc atgggcaccg aaaccgtgca atgcagatgg tcaccttcgc
2653201 ggacaaagac gtcgtgcgcc tgctcatgga cctcgacgta gaggtcaccc gccggccctc
2653261 ccccgggccc gacctcgccc tgagcggcga gccgaactcg catcccgtcg ccgacaccgg
2653321 ccgggatctt gacgctgatc tcccgacggg cccggatccg gccatcgccc atgcattgct
2653381 ggcacgggtc ggggataacc accccgacgc cgcggcaggt gggacacggc cgcgacgtca
2653441 acatctgacc caacagcgat cgctgcacgg tctgcacctc cccgcggcca ccgcaggtgt
2653501 cgcagggtat cggaaccgaa tcgccgttgg tgcccttgcc ctggcaccgg tcgcacaaca
2653561 ccgcggtatc gacggtgacc tgcttggtga cacctgttgc gcactcttcg agatccagcc
2653621 gcattcgtag cagcgagtcc gaacccggcc ggacccggcc gatcggccct cgggacgccg
2653681 cgcccccacc gaaacccccg ccaaagaacg cctcgaacac gtcgccgagg ccgccgaagc
2653741 caccgaaccc attgccgccc gcagcggcgc tctccagcgg atccccgccc aggtcgacga
2653801 tgcgacgttt gtccgggtca ctgagcacct cgtaggcgac gctgatttct ttgaatttcg
2653861 cctgcgcagc ctcgtccggg ttgacgtcgg gatgcagctc gcgcgccagc ttgcggtagg
2653921 cgcgtttgat gtccgcgtcg ctggcgttct tgctcacgcc gagcagcccg taataatcgc
2653981 gtgccacgct tgattctcct atgccgcgtc tttatgccgc ttctcaagcg gctatccaca
2654041 aaccctgcag caggtgcgcg ttcatcgagc acccaggacg tcgccgatat aaagagcaac
2654101 cgcagccacg ctggcgatag ttcccggata gtccatccgg gtggggccca ccacacccat
2654161 accgccgtag acggtatggg cggtaccgta ggccgtcgac accatcgagg tgcccaccat
2654221 ctgctcagac gccgtctcat gacctatgcg aaccgtcacc ttgccggctt cctgctgagc
2654281 cgccagcagc cgcaacacca ccacctgctc ctcaagtgct tccaatattg accgcagtga
2654341 accaccgaag tccgcagcgt tgcgggttag gttggcggta ccgcccagca aaaggcgttc
2654401 ctcggtgtgc tccactagcg actccagcaa tacggtcgcc gcgcggccca cggcgtcgcc
2654461 caatccgccg gcgccgccca gctggctggc gaggtcggcg accgccaccg aagccgctga
2654521 aagcttcttg ccttccagcg cctggccgag tatttcacgc agctgggcta gctggtgatc
2654581 gtcgatgaca tcgccgagtt cgacgatgcg ctgatcaacc cggccggagt cggtgatgac
2654641 caccatcagc agccgggccg gtgtcagcgc gatcacctcc aagtggcgaa cggtcgacgt
2654701 tgacaacgtc gggtactgca cgacggccac ctggcgggtc agctgcgcca gcaatcgcac
2654761 ggcacggcgc agcacgtcgt cgagatcgac accggattca aggaagctct ggatcgcccg
2654821 gcgctcggcc gacgataggg gtttgacgtc ctcgagccgg tcgacgaact cgcggtagcc
2654881 cttctccgtg ggcacgcgtc cggaactggt gtgtggctga gtgatatagc cttcggcttc
2654941 cagcaccgcc atgtcattgc ggactgtggc cgacgagact cccaggttat ggcgttccac
2655001 cagggatttg gagccgatcg gttcctgggt tgcaacgaag tcggcgacga tggcacgcag
2655061 cacctcaaag cgacgctcgt cggcgcttcc catcgactgc tcacctcact tcttacgctg
2655121 cctgaccggc ttcattttac gttctcggcg gccactgacc gtcatctagc aggcgtctgc
2655181 cgatggtcag ggggcgtgtg ccccgactaa cgtgtccagc atgatctcgt cgggcttcag
2655241 ccactcggta gggaagatcc gccaatgatc ttcaaagggg tgcgggaagg caagccgtat
2655301 cccgagcatg gactgtccta tagggactgg tctcagatac cgccgcaaca gatccggctc
2655361 gacgagttgg tcaccacgac tacggtgctc gcgctggacc gcctgctgtc agaggactcc
2655421 acgttttacg gtgacctttt cccccacgcg gtgaagtggc gaggcaccac ctatctcgag
2655481 gacggcttgc accgggcggt gcgtgcggcc ctgcgcaacc gcaccgtgct acacgcgcga
2655541 gtgttcgaca tggacgcgtc accaggcggg cggcgtagct gaacagcggg ctgaagccgg
2655601 cccgccaatc agttccctgc ggcctgcagc aactccatcg ccgatgcgcg tgacagcatc
2655661 cagccgcctt gattcacgaa cgtgacgttc tgcgtgaccg gcgacgagag cttcggaccc
2655721 gagacggaaa cgtcggcggt ggccgaaccg gcggccgccg gctggatgtt cgtcacgctg
2655781 aacgacagcg gcagatcccc gtgctcggcg gccttcttca gcttgtggtc ggcgatgcgc
2655841 gcctcggtgc ccccgatgcc gccctcgacc agactgccct tgttcgcaaa cgacacgttg
2655901 ggatcggcga ggctgttgag caggctggtc aactgggcgg cggtcgggac gtcaggggcg
2655961 gatgccgggt ccaacggcag tggcgcgccg aagacgaccg gctgcatctg gtatacgacc
2656021 gggccgccag ccatgatcga agtcacaccg gccgcagcgg cgccgattgc agccgcggcg
2656081 gtcagacctg cggcgatcga tttcaccatc ttcatggttg tgttcttccg ttcgtttgcc
2656141 cgtcgattgt gcgtttggtt caaactaccg gtgcacgcgc cgggcaagtc tgtgtcgtag
2656201 ctgtgagcga gcggtcagtc ctcgaccatg gcgtcacgca ggctcttcgg ccgcagatcg
2656261 gtccagttct tttccacgta gtccaggcag gcggcacggc tggcttcgcc gtgcaccacg
2656321 cgccagccgg ccgggatatc ggcgaacacc ggccacaggc tgtgctggtc ttcgtcgttg
2656381 accagcacga agaatgcgcc gttgtcgtca tcgaaaggat tggtgctcac cgcttctcct
2656441 tgtgtcgttg tgtttggtcg gcgtaaagat gccggcgccg agcacccggt ccgacaacaa
2656501 gccgaggcag ctcaggttgg ggaacccggg cccctgggtg agtccggaca gggtgggcag
2656561 gaacagcttg ggcgtgacgt cggtgactgc caagtcgtag ccgatcgctt cctgcaggcg
2656621 gtcggcggtc agcggtccac ccagtcccag ctcgagcagg tcgagggtgt gctgactgaa
2656681 cagtgaggtg aaccacagcg gatcggcgcc cgagccgtcg atgacgagat cgaatccgtg
2656741 cacggtctcg aagttctcgc tgccccggtt ggtgctcagc gtcaaccgga tctgcccctg
2656801 acggcccacc gcgtgggcga cccggccacg cagatgatgg atgcggtcat cggccagcag
2656861 cgcttcctgc acggtcgccg agaacactcc tcggtcggtg cgggccagcg cgtcgcgccg
2656921 ttcgtcgaac gtcaaggccg cccagtcggt cggatcggaa aacagtgagt tctcgaagaa
2656981 tccctcgccg cgggtgaaca gggttacctg cggggagatg acggtgatgg ttgagacccg
2657041 atgccggaac agctcgttga gcatcgatgc ggccgtctct ccgccaccga tcaccgcgac
2657101 ccgctcggcg ttgatccggt cgtggccggc ggcacggtcc cagaactgtg cgattgagag
2657161 cacgcgcggg tttccgggca gtagcgactt ttcagcctgg ccgggcccgg tgatcatcaa
2657221 cgcgtcggcc tgcacggtgg tctcgtgggt gcacaacgcc cagcggtcac cggtgacggc
2657281 gagccgttcg acctcgccgt ggatcacctt gaggccaatg tgatcggcca cccaggctag
2657341 gtactgactc cacctgcgat gggtgggcgc cgggcggccc cggtcgatcc attccgcgaa
2657401 cgacgcggtg gcgatcagat acgactgcca gctgtagcgg gtcatccgct cgtccaattc
2657461 tgcgttgcgc cgtggcacca gcgccgaccg gtagggaaaa ccgacatcct tttctgggct
2657521 ggtgcccagc cggtgggctc cgtcggtcca gccaccgctg gcctgccagt tggccccgac
2657581 cccgatgcgt tcgacggcga tcacgtcggg cacgtcgacc cccatgtcac gcagcacgga
2657641 tgccttggcc gcgaccgcca ccgccttggc tccagcgccc aggaccgcga gcgtcggatt
2657701 catgctgtta tctccgccag cgcgccctgc cacagtgatt gcagcgtggc gacgtcgtcg
2657761 gcggacagga tgtcgggcag cgtgcgccac cgcgtggcta gcacgggagc gtcggcgggc
2657821 ccgaggagcg ccgccagcac cgtcagttcg tggcgcaccg gctgttcggg ttcaggcagt
2657881 tgccccacat cagccagtag tgcgcggtcg accgccagat ctcccacccc gacgtgcagg
2657941 ctacccagat agttcagcag cagctggggt tcgcggtggg cgcgtagtcg ctccgcggta
2658001 tcggcgcgca ggtaccgcag caggccgtaa tcgatgccgc tgccgggtat ccgcgcgaag
2658061 tcggtcgcgc cgtcgcagtg gatgcgcagc ggatagatcg cgctgagcag cccgaccgtg
2658121 tcgctggtgt cggcagtctt atcgacgtgg acgtccgcgc ggccatgcgt ctccaacgcc
2658181 aacagcggtg ctggtgtttg ttgaccgcgt tgccggcgcc aggcggtcac catccgcgca
2658241 gcggcggtag ccagcagatc ggtcatcgac cgtcccgtcg aaagcagccg cgcggtcaga
2658301 tcggcgtcgg agatcgacat ggtgatcgct agctcaccaa cccggtcggt ctgcggcgcc
2658361 accctgcggg cacccaacgg cggatcggcg ccctcgagtt cggcgaccca gaaatcaacg
2658421 ctatccagcg ccttagcccg ctgcgccagc agccgcgacc actgccggta gctggtgttc
2658481 tcgcgcgctg ggctgggcgc gcgcccggcc gccagcgcgt gcaggccggc gtcgagttca
2658541 cccagcacaa tccgccagga ggctgggtcc atcgccagca catgggcggt cagcaccaga
2658601 acaccgggcc cgtcgggttc gcgcagccac accgccgaga gcagtcggcc ggcctggggg
2658661 tcgagactcg ccagcgcgcc aagagtctgc tcggccaccg cggtgaccag ttcaccgctg
2658721 acccaaacct cgctgagaat gtccgttttc ggttgtgcga caagggccat cgcatcccgg
2658781 tcgaaccggc accgcaacac ctcgtgtccg tcgacgaccg cggccaacac ggcatccagg
2658841 cgttcgcggg tgatccggtc gggcaacctg atgacctcgg tttgtgccag ccggcgcggg
2658901 tcgccgtact cgtagagcca atgagtgttg ggtagcaccg ggatcggctc gccggcatcg
2658961 ttggccggtg cctgccatgc ggcatcggag tcaatggccg ccgcgagttc acggatggtg
2659021 tcgcactcca ccatcagcct ggcccgcaac gcaatcccac gacggcgcgc ggcctgcacc
2659081 accgacagcg ccacgatgct gtctagaccc atctgcaaaa agcccgcggt gacatcgacg
2659141 ttcgaggttt ccatgacatc ggcgaacgcc tcggccagca ccagctcggt cggtgtctgc
2659201 ggcggagttg ccggtccttc ggtgacattg attgccgcca aagcgttttc gtcgatcttg
2659261 ccgtgtggag tcagcggtaa ctcgtcgagg acgacgatat ggtgcgggac tagataacgc
2659321 ggcaaccgct ctagcagcat cgcccgcaat tcggccaccg gtggcggttg tggtccgcct
2659381 gccacatacg ccgtcagccg ggggccactg gcatggccgc gggccgtcac atggcaaccg
2659441 tgcaccgcat ggtggccgtt gagcaccgcg gcaatctcac ccggctcgac gcggaaaccg
2659501 cggatcttca cctggtcatc gctgcgcccg aggaactcca gtccaccgtc gggcaggcgg
2659561 cgcaccacat ctccggtgcg gtacattcgg ctaccgcgcc cgtttggctc agcgacaaag
2659621 cgcgccgcag tctcggccgg gcggccgagg taaccgcggg tcaactgggc gcccgccaga
2659681 tacagctcgc cggcgacgcc atcgggcacc ggccgcagcc aggagtccat gacgtaggcg
2659741 cgggtggtgc aggtcggacg tccgatgacc ggtcgcgcat gctcagcaac ggcggcgacc
2659801 acggcttcga ccgtggtctc ggtaggcccg tagcagttga aggccgtcat ggccgtgcgc
2659861 gcgcagttct gctggatcat ccgccacgtc gcggcgccca aggcttcgcc gccgagcgca
2659921 agcaccgcca acggcgcccg gtcgagcagt ccagcgttgt gcagctgggc gaacatcgac
2659981 ggcgtggtgt caatcatgtc cagaccgaat cggtcgatcg cttcgaccag cgcccctgcg
2660041 tcccgctgac gatggtcgtc gacaatgtgc accgcgtggc cgtcaagcag tgcgaccaac
2660101 ggctgccacg ccgcgtcgaa ggtgaacgac caggcatgcg cgattcgcag cgggcgcccg
2660161 agccgctggg ccgccggccg caacacgcgc tcgatgtggt cgtcggcgta ggccgacagc
2660221 gcccgatggg tgccgatgac acctttcggg gtaccggtgg tgccggaggt gaaaatcacg
2660281 taggccgcct ggtccaccgg caccgtgatg gcacggtcct cctcgagtat gtcagcgcca
2660341 accgaagcgg cgaacacgcc ctcatcgatg accaccggag ccgatgtctg gcgcaagatc
2660401 tcggcgacac gctcaccggg catcgccggg tccagcggca cgatcatgcc acccgccttg
2660461 aggaccgcca gcatggcggc cacgtagcgc ggaccacggg acagcgcgac ggccaccggg
2660521 gtctcgcgac tcacgtccgc gcggcgcagc ccagtggcca gccggtcggc caatgcatcc
2660581 agctcccggt acgtcagctg accatccgcc caactgaccg ccaccgagtc aggctgtgcc
2660641 gcagcgattt cggcgaaccg ggtatgcacc gcgggtgccg acgtcgtcac atccggcagg
2660701 ccgggtgcgg tcggatcgtg ctcgccgtcc agcagaatgt cgacgtcgcg cagcggccga
2660761 tcccaccggc tgaccaagcg ctgtaacaca gccagcaccc gcctgccgag gctttcgggc
2660821 gccatcgtgc ccagcgcacc gtcgagcacc tccactagca gcgtgagctc accggtgctg
2660881 cggtgcgcgg cgacggtcac cggaaagtgc gacaaactct ctagcgccac cggacggaac
2660941 gtcaccccgt ttgcgacgaa ctccgcggtg cccaccacct cgccgggcgg gaagttctca
2661001 tacaccagta gggtgtcgaa catctcaccg ataccggcga tggcacgaaa ctcgttgaaa
2661061 ccgagatagc tgtggtcgcg caacatggcg aattgacgtt gtaggacagc gcattgcccg
2661121 ccgacggtag cgcgggcgtc caggcggacc cgcagtggca ccgtattgat gaacaggccg
2661181 atcatcgttt ccacgccgga cagttcgctg ggcctgccgg acaccgtcac accgaacgtc
2661241 acatcgccac gaccggtgaa tgctgaaagc gtggtagccc aagccatttg aacaagtgtg
2661301 ctgatcgtga cgccacgggt gcgggcggca tcggccagct ccgcggtggc ttcacggtca
2661361 aggcgcactt cggtgcgtcc cggaataccc ggctgcacag gagtgtcggc gagtgccggc
2661421 gataacagag tcgggccgtc caggccattg aggtggtccg cccacattgc gcggctagcc
2661481 gtctgatcgc ggccggccag ccagccgatg tagtcgcgat acggccgcgg cgctgccggc
2661541 aacgcggcga cgtgaccacc agcccgatac aaggcgagca gctcggagac gaacagcggc
2661601 aacgaccatc cgtcgatgac gatgtggtgc gcgacgatga ccagatgcca acattcgtcc
2661661 ggtagttcga tgagcaggaa ccggatgagt ggtccgcggc cgacgtcgaa gcggcgccgg
2661721 cgctcttcgg ctgccagcgc cccgacctca ctggggtggg cgcgcacgtg acgccaaagc
2661781 acctcggcac tggatggtat tacctgcacg ggccggctca ggttcccgtg taggaagctc
2661841 gcccgcaggt tggggtgccg ggtcagcatc gcggcagcgc agtcgcgaag caaggcgatg
2661901 tcgagcgggc cggccgcgtc ggccgccatc gcgatcacat acgggtcggc ctctgcggcc
2661961 tcagagccgg actccgcggc gaccagtgtc gccctagaaa acagtccctg ttgcaatggg
2662021 ctgagcgcca tcacatcgtc gatggcgccc cgcgcgtcgg ctcgcgtcac ggccactggt
2662081 cccatgacgc ggtcagggcc gacagttcgt ctggggaaag ccctgatgtg ctcatcggcg
2662141 cgtgatgctt gtcgtccggc tcggcctcga cgtgaggctt ggcgtcgacc gcggcggcga
2662201 gctcacacaa aacgggatgc tcgaaaacca tccgcgcggt cagcggtatc ccgccatctc
2662261 gagcccgggc agccacctga gtcgcgagga tgctgtcgcc gccgaggttg aagaagtcgt
2662321 cgtagcgtcc gacctccccc acctcgagca cgtcggcgag gatggcagcc agcgcgcgct
2662381 cggtttcggt gtcggcgggc tcggccggca ccggtgccgc ctgcgccgtt ggcagccgtt
2662441 cgatttcggc cagcagctcc agttggccgt cggccttcca cactccgcgc tcgccgttgc
2662501 ggtagagccg agaacccggt tgcgcggcga acggatcggc aacgaatcgg gtcgcggtct
2662561 ccgatggccg ggccaaccgg gcaccgacgg cgggaccgcc accgtaataa acgtcaccca
2662621 ccacgcctac cggaacgggc ttaagtgcgt cgtcaagcag gtacacccgg gccgttccgg
2662681 cgcccgcatt ggaccggtcc aaaatgcgcc gtctggcttg cgcgctgacc atctcgacct
2662741 cgcgcagcgg ttggtccgga cggtcggcga acgcctcgac gacacggact agccagtcgg
2662801 cgaagcgttg tgcggtggcg cgctcataca actcggtgcg gtagatgacg tggccgcggt
2662861 actcgtcgcc gcaggcgaag aagttgaccg atagatcggc ttgcgcggca tcgaatgtcg
2662921 gctccagcac gcgcaacgtg gtgtcaccgt cgggcccggt gtcgatgacg tggtcttgcg
2662981 gcatttgttc gcgaacgtgc acaacaatgt cgaacaacgg attgcgggac agcgaccgct
2663041 gggggttgac cgcctccacc acctggtcga acggcaggtc ctgatgtgca tacgctgcca
2663101 gcgccatctg cctggtgcgc tgcagcacct cgcgcagcgt ggggttcccg cgcaggtcgt
2663161 tgcgcaacac cacgatgttg atgaagaacc cgatgagctg gtccaggttg gcctcgctgc
2663221 gaccggccac cggggcgccg atggggacgt ctaccccgcc gccggccttg tgtaacacca
2663281 ccgcgacggc ggcctgtagc agcatgaact cggtgacacc gaggtctcgg ctcacggcag
2663341 ccaatttgtc gcggatcgcg gcgccgagac gaaattcgac cgcgtcaccg gcaccgctga
2663401 gcagggccgg gcgcgggaag tccgggcgca gaccggtttc gcctgccagg ccccccagct
2663461 ggcggatcca gtagtcgcgt tgcggaccga cgatgcccgc accgtcgtcg agtagcgccg
2663521 actgccacac gctgtagtcg gcgtactgca ccggcagcgg tgcccacgac ggccgttgtc
2663581 cggtgctgcg ggcccggtat gcggtcagca gatcggtgaa caacacccca gccgaccagt
2663641 ggtcgccggc gatgtgatgc accaccagcg acaacacggt ctgctccggc gtgctcagca
2663701 gcgccgcccg gatcggccag tcggtttcca ggtcgaaaac gtaacctcgc tcgttgttca
2663761 gttcggctcg cagccacgcg gcgtcggacc cggcggcgca ccgcaccggc acctcggcgg
2663821 gcggctggat gatctggtgt ggcacgccgc cgatctcgcg gtagacggtg cgcaggatct
2663881 cgtggcgtgc caccacatcg gtgatggccg ccgcgaacgc gttggtgtcg cagggcccat
2663941 gcaatgccgc ggcgaaggga atgttgttga cggcgttggg cccgtcgaag cgatagttga
2664001 accagctacg catttgagac gacgacaatc gcactggccc gtcatgatcc acccgggtca
2664061 gccgcggcct cgccgaatcc gaatccaacg tatcgatgtg tccggccaac gcggtcaccg
2664121 tggcgaattc gaagatctcc cgcacaccga catcgacgcc gaacgcgttg cgcacggccg
2664181 caacgagttt ggttgccagc agcgagtgac cgccgaggtc gaagaacgag tcgtcagcac
2664241 ccactcggtc gcggccgagc agctcaccga acagttgggc aaggcgccgc tcggtggcgg
2664301 tctgcggcgc gcggaactcg gtgtccgacg cgatctgcgg ttccggcagc gcggcgcggt
2664361 cgattttgcc atgcgcggtg atcggaatct catccagcac aacataggcc gcgggcagca
2664421 tatattcagg cagtgccgcg gccacccggg cgcggatgcg gtcgagatcg acgccgacat
2664481 cggcgggtcc gtcgccgccc gcggcgggtg tcacgtagcc caccagactc ttgcccagcc
2664541 gcggcaggtc gctaaccacc acaacggcct gcccgaccgt agggtcgacc gcgatggccg
2664601 ctgctacgtc accgagttcg attcggaatc cgcgaatctt gacctgctcg tcggcacggc
2664661 ccacgaactc gatgtcaccg tcagcattgc ggcgcgccag atccccggac cggtacatgc
2664721 gggaaccggg attaaacggg tcggcaacga atcgctccgc ggtcagcccg gcgcggcgat
2664781 ggtatccgta tgcgacatgc gtccctccaa tatagatctc gccgatcaca ccggtcggca
2664841 ccggctgcaa cgaatcgtcg agcaggtgca tggtggtgtt gatcttgggc cggccgatgg
2664901 gcacgatgcg ggtgccctgt gggcccacca ctttaaaccg gctggcgttg atcacggttt
2664961 cggttggacc gtagaagttg tgcagcagcg catcgaatgt cgcgtggaac ttgtcggcca
2665021 cctcaccggg tagcggctcc ccgccgatgg gtacccgctg caacgtccgc cactggctca
2665081 cacccggcag cgacaggaac agcccgagta gggacggcac gaaatgcatt gccgtgatgc
2665141 cctcgtcgcg caacagggcg gtgagatatc caatgtcggt gagtcccccg gggcgtggta
2665201 tcaccatccg cgcgccacag gccagcgtgc cgaagatctc ggcgatcgag acgtcgaagc
2665261 tgggtgaggc gacctgcagt agccggtcgg tgtcgtcgac gtcgtattcg cccttgaacc
2665321 agacgaagta ctcggcgacg gggcggtgtg gcaccgcgac acctttgggc aatccggtgg
2665381 taccggacgt gtagatgaga taggccgtgt tgtctggccg tagcggccgg attcgatcgg
2665441 cgtcggtggg gtcgtcgctg cggtatccgg ccagctcacg tactggcgtg cgcagcacca
2665501 gtttcgcgtc gcagtcggcg aggatgaaat ccagccggtc ttgcgggtag ctgggatcca
2665561 cgggcacata caccgccccg gacttgacca cccccaaggc cgtgacgatc aggtccggcg
2665621 atttgtcaag aagtaccgcg acccggtctt cgctgcctat cccctgctcg atcagccagt
2665681 gccccaaccg gttcgacgcc tcattgaggt cgtggtaggt gaagtgttgg ccctcataca
2665741 ccacggcggt ggcgtcggga gtccgcgtgg tctgctcgtt caccaggtcc acgagggttt
2665801 tgacaggggt atcgaaccgc tcgccgcgcg acacctcgcg cagcctggcg gcgtcgcgct
2665861 catccatcag cgccagcccc gacaacgtgt tgtcgggggc ggccagcgca ttgtcgagca
2665921 gcacaccgaa gtgtcgaagc atctgcttgg ccagggcggg ttccaggatc tccaccaggt
2665981 gttcggcctc gaccagcaca cccgcgcggt cgaattcgac catgaagccc aacggcagct
2666041 gcgtgatgtt gctgcgcagg tcgtagcgct cgcactcgat gcctggcggg ttgaatccgc
2666101 cgccgtcggg ctcccggaaa ccgaagctga cccgggtcat gcgctcggca ccgtgccggc
2666161 gatcggggtt cagttccctt accacgcggt cgaggttgat ccgttggtgt gcgaacgccc
2666221 cgctggcgat gtcgcgggtg gcggtcagca actcccggaa actcatcgcc gattgcggtc
2666281 gcagccgcat cgctaccgtg ttgccgaaat agccgatggc atcttcggtt ccggcgccac
2666341 ggttgagcac cggagccgcc acgaggaagt cgtcactgtg ggtgtagcga tgcaccaggg
2666401 caccgaacgc ggccagcagc accatgtagg gagtgcaacc ggtgttcttc gccatcgtgg
2666461 ccacccgcgc agcggtgtcg gcgggcagcc gcaacgtggc gcgcgcggca cgccaactgg
2666521 tcggcacaca cgttccggct gggccgggaa gttccagcgg ctctggcgga tcggccatga
2666581 tcgcgcgcca atagttgagg tcggcctcgg tagtgtcggg tccggatgcg gccgacggac
2666641 ggtgttctgg ccccagatcg gcccctaggt cagctcgcga gtacgcctgg gtgagatcgg
2666701 tgaagaacac ccgccacgaa ccatcatccc aggcgatgtg gtgggccacc aacagcagca
2666761 cgtgttcgtc ggcagccgtg cgcaccaccg tgattcgcaa tggcgcgtcg cgggaaagct
2666821 cgaagggagc gcagaattcg cgctgagcca acacctccag gcgcagccgc tgggcgcgtt
2666881 gggacaggtc cgtcaggtcg tattgtgtcc agccggggcg aagatccgcg tgcacggtcg
2666941 gctgggcgac tccgtcgtcg ccgacagggt aggtggtacg cagtatccga tggcgacggg
2667001 cgacggcgtt gactgcgtcg cgcaacctgg ccagatcgat gtcaccggtg atgcggtagg
2667061 acacacagat gttgagtaac gcaccgctgg ggtcggccat ctgcacgaac cacatccggg
2667121 cctggccgtc ggagagccga tcgtcagtgt gcgggccaat gtcctgcgca gccgaggaca
2667181 ggccgcggtc ggcgagcctg cgacgcagca gctccaatcg ggcctcgtcg aggcgggcgc
2667241 cgatgtcggc ggtattagtc acgcgaaatg tccactttct gtgcggtgtg tgagcgctcg
2667301 tcggcatctt cgagtttcgc gacaagtcca tcaccggtga tgtcgcccat gagcgtggcc
2667361 agcgacaccg tcgcgccgat tgatcgtttg agtcggttac gcaagtccag tgccagcatg
2667421 gaatcgacac cgagatcgaa cagcgattcc tgcaggttca cctcgccggc ctgcgggatc
2667481 ccgagcacgg ccgccaattg ggtgcgcacc gcgtccacga tcgtcaggtt ggggtcggtt
2667541 ggaccctcgt accgttcgaa ttgcctgctg tccaacaaca tctgcaaccg ggccgcgtcg
2667601 gcggcgaaca ctagcgggtc gacagtgaat tcgtgcaggc tcgcctcgat cgcctgctgg
2667661 ggcgccatct ggcggagtcc agaccgctcg acgcgggcga tcgtaaccgc atccgcgatt
2667721 ccccgagctg gttcgccggc cttgggggcc tgccataggc cccatttcac cgccacgcag
2667781 tgcctgccct gggcgcgcag ctgggcggcc atcacgtcga gcagccggtt ggccgccgag
2667841 tacgcgacca ccccgtgtcc accccacacc cccatcaccg aggaacacag cagggttcgc
2667901 acatccgggc gcagcggcca cagctcgatc atctgggcca ggccgagcac cttggccgcg
2667961 aagttgtcaa cgacggcggc cgacgtcacc cccggtgcgg taccagagat cacgctgcct
2668021 gccgcgtgca cgatcaacga ggcgccgacg ccaccgtatt cggctgcaat cgctgacaac
2668081 tgggtgggat cggtgatatc gcacggcggc gacacgatca cggtgccatg ttgctttctg
2668141 agcatggcca ccgtcgcctg atccgcggcg cgccggctga gcagcacgat gcgccgtgcg
2668201 ccatgctcgg cgagataccg cgcgtagtgc atcccgatgg cacccgcgcc accggtgacg
2668261 acgacatcgt cgagcacgcc ggagtccaac gaccagttcg ggacggccgg ggcatcggcg
2668321 agggttcgct cgaacagcgt gtacccgttt accgagccgc gtagcgcggt ctcaccgaag
2668381 ccccgcagta ccgccgttat gaccgagacg ccgaggaccg ggtccaagtc ccacgacggc
2668441 aagtccaggt ggctgaaagt ctgttcggga tgctcgaatc cgatgcttcg atgcatcgcg
2668501 gccagcgcgg cctggccggc cgacggcacc gcgtccgctg cgtcgacctg ctcggcgccg
2668561 acggtgacca gacataccga ttggcaacgg gcaccgatat gcatcggata gtccagcaaa
2668621 ccggccccga cgaggtcggc gagtgcaccg gcggcccgga cggcgtcggt gtgttcgaag
2668681 tcgggcgcga tcaccaggat caactcggcg tcccgcgcag cactcagctc ggtatcgggg
2668741 tgcgaatcaa ttgctgcgca cagtgtttga gccagcgcgc ggtgagcacc gagatcgagc
2668801 actgcgaggt gacggtgccg cccagcgacc ggtgtcgacg gcaccatccg ttcccaccgc
2668861 tcaaccgcaa tggtcagtcc ggacaccggc ggcagcggtt cggggtgcgc ccacatcggc
2668921 accgcacgca tcggcgcgtt cgggaacccg gacagatcga cgtcgccgtc gagtgggtca
2668981 ccgcccaggt caccccacgg gtagccaggg tcagcgaccg ccgcgctaac aatattcgcc
2669041 gacaacgcat caacaaaccg ctcgccacga cgtgccgacc cgaccagcac agcgggaccg
2669101 tccggcaggt tggcggcgcc ctcacagttc tgaccgatcg caaacaacag cgcgggatgg
2669161 gccgatatct cgatgaacgc ccgtgctcca cagcggattg ccgattcgac agcgcggtcg
2669221 aaacgcaccg tatggcgcag gtttgcgtac cagtagtcgc cgaaagtggt gcctggcgcc
2669281 accacgtcgc cggtggttcc gccgatgaat tgcactggcg cttccataaa ttcggagtca
2669341 ggcagctgct cgcataattc atcgcggagc gattcgagca cgctggtatg caccgggaag
2669401 cccacggtga tcccgcgggc gaagtgaccg ctggaccgga ctgtgtcaac gatggccgct
2669461 accgcttggc gctcaccgga cacggcgacg gtcgaggagg cattgaccac agacagttcc
2669521 agccagccgc cggtggtcgc gatcagcgcg ctcgcgtcct gttcaccgat gcccagcgcc
2669581 gccaccgcat agcgaccagg caagcggccc accacgttgg cgcgggccgc caccacggcc
2669641 acagcatccg acaaggtgat acttcctgcg agataggccg ccgctacttc gccgaggcta
2669701 tgaccgactg ttagatcggg cagcacaccg caggaacgcc atacctccgc cagcgcaacg
2669761 gcatggacga actgcgcgcc ttcgatctcg atctcgcaga acgcttgccg ctcatcggtt
2669821 ccgggcgggg cgatcaggta tggcagcggc gagtcgacac cagcggccgc aaatgcggcg
2669881 gcgcacgtgt cggtcgcggt ccgataggtc ggcagctcgc ggtaggcgac ggcgcccatg
2669941 cccggccaat gaccaccctg gccgggaaag acgaacgcct ggcgcggggc cgagcccaac
2670001 gacgaccgcg cgatgagcgg atgctcgcgt ccggcggcca gcgcgcgcaa gccctcggcg
2670061 agttccagcc ggtcggcggc ccgaagcacc gcccgatgcc gacggacccg tcgggtcttg
2670121 cgcagctgcc gagccacttc ggtcacggtc gtagccggaa agcgctcgag gtagtcggcg
2670181 atggcccgag cgtccggccc gatcagttcc tcggcatggg cgctgagcaa aaccgcaacc
2670241 cgcccatcgg gcagctgttt gggggccatc acacctcccc acactcgggg ccacgctcgg
2670301 gcgcggaaac ggtgtccggc atcgaaacga tcacgtggct attggtaccg ctcatcccga
2670361 acgcggacac cgccgcggtg cgccatccgt caacggcccg ccacggcgtg agtttgtcgg
2670421 ccagccgcag accctgtttc tcccaatcga tttcgcggct gggctcgtcg acgtgcagtg
2670481 tcggcgggat cgcggcgtgc tgggcggcca gaatgacctt cacaaggccc agcccgcccg
2670541 ccgccgcctg agcatgcccg atgtttgact tgaccgatcc caacagcggc ccgcgtccgg
2670601 ccggggcggt gccgtagctg gctgccagtg accgcaattc ggtgcgatcg ccgagccggg
2670661 tcgcggtgcc gtgcccttcg accatcccga catcggcggg cacaactgct gcctgcgcga
2670721 tggcgcgccg gagcagtcgc gtttgcgcgt cgccgctggg cgcggtcagc ccgtcgctaa
2670781 gtccatcgga gttcaggcaa ctggcacgca cctcggcgag gacacgacgc cggtcagcgg
2670841 ttgcccgcga ccggcgctgc aggaggaaca tggcggcgcc ctctgcccag gcggttccgc
2670901 tggcgtgcgc gctgtagggc cggcagtggc cgtcgtcgga tagcgcgtgc tgcttggaga
2670961 actcgacgaa atagccgggc gtacccatca cgcacacgcc gccggcgagt gccaggtcgc
2671021 agtcgccggc ccggatagct tgaaccgcgg tgtgaaaggc cgccagcgcc gacgaacacg
2671081 aggtatcgac ggtcagcgcc ggcccggcca ggtcaagggt gtaggcgatg cgcccggaga
2671141 tgacacccag cgacgtcccg gtgatcagat ggccactgtg gtgggagaat tcggtcaaag
2671201 cgggaccgta ttcgagcgcc gaggcaccga cataacagcc cacatcgtga ccggccaggt
2671261 catcgggatt gatcccgctg ttctccaggg tgcgccatgc tactcgcagc cccacccgct
2671321 gctgcgggtc catcgccgtc gcctcgcgcg gtgagatgcg gaagaactca ggatcgaatg
2671381 tagttgcgct ggaaaggaat ccgccaaggt tgtggatcgg tttgaatccg tttcgacgcg
2671441 acccgtcgaa cagctcgcga agtgcccaac ctcgatcggt ggggaacggt ccgagtccct
2671501 cgcgctgttc ggagagcagt gtccagtagt cgtcggcggt ttcgacacca ccgggtgcct
2671561 cgatggccag cccgacgatg acgaccgggt cgttatcgga catcggcact caccatccgg
2671621 gccacggcgt cgaggtgatc gttgagatag aagtgaccac catcaaagtg cgacagcgtg
2671681 aagcgaccgg aggtgtgagt ctcccaactg gtcaacatct cccggctgat gcggtggtcg
2671741 cggttgccgc cgaccgcgtg gatgttggcg cggatgcgca cgtcgggtgg acatgaatag
2671801 ccgctgaggg cccgatagtc ggccttgacc gccggcacca gcagttcaac gaattcctcg
2671861 tcctcgagca gcacgggatc ggtgccgcca agatccacca tgtcggccag gacgtcacgg
2671921 tcggcggtcg gcaacggtcc ggacgcggcc accgtcgacg gagcctgacc ggaggaagcc
2671981 cacagtgcac gtaccggcac gccattgcgc tcggcgaggc gagcgaactc gaaggccact
2672041 atcgcaccca tgcaatggcc gaacagcgtc agcggagccg tcaggtgcca gtcgcccgcc
2672101 tcgaacagct cgagcgccag cgcctcgatg ctgtctgccg ccgggtggct gcgccggtca
2672161 gcccgctgcg ggtactgcac cacgaacgtg tcaacgtcgt tggccactaa cgattttgcc
2672221 aaccaccggt aagccgcggc agcgccgccg gcgtgtggaa acaccagcac cgcgccgggc
2672281 ttgtcagtac cggtgaaccg cttcacccac ggtttgaagg ctggctgtgc gggctgctcg
2672341 atcggatcga gcgccgccat cacgtcggca cttgtcatat tcgcgatttc taagtacacc
2672401 tcggcgacca gttcgagtcg gtcggcgttg gcttcccgac cggtgagcaa ctgggccaac
2672461 gcggcaatgg tcctggcggc aaacatgtcg gcgaccatca ggctcggcga atccagccac
2672521 cgccggatac cggcgacgac ctgggtcgca agcacggaat cgccgcccag ggcaaagaag
2672581 tcgtcgtgca cgcccacggc atcgttggca cggcccagga tgtccgcgac gatgcggcgc
2672641 agtgcccgct gaagcaccgt tcgcggcgcc gcatagggtg ccgatctgtc gccagaccgc
2672701 tcgacctcgg cggcaagcag ggcgccaacc tccgcgcggt cgatcttgcc gctgtcggta
2672761 aaggggatgc ggtctagcag cgtgacgtgg cgcggaatca tgtgcgcggg caccagatcg
2672821 gcgagctgct gtcgaatcga ctccgcggtc acgccggcat cgtcgacgca gaccgccgcg
2672881 gccagcacat cggacccgcc aggaagcacg gtggccgccg ccgcgtgcac accgggcaag
2672941 cgctgcagcg cggcttcgat ctcgccgagt tcgacgcggt acccgctgat cttgacgcgg
2673001 tgatcggcac ggccgacgaa ctccagggtg ccgtcgtgcc agtagcgggc cagatcaccg
2673061 gtgcgatacc aggtgcggcc gtcatgctcg acgaagcgct ccgcggtcag ctcgggacgg
2673121 ccacggtaac cccgggcgat tccgcgaccg gacacccaca actcaccggc cacccaatcg
2673181 gggcagtcgt cgccgctgtc ggccactacc cggcaggcgt tgttgggaaa cgggacgccg
2673241 tatggcaccg aggcccagtc cggtggcaga ttggccgcgt cctggacctc gaaaatggtt
2673301 gcgtggaccg cggtttcggt ggctccaccc aaccccgcga accgtgcgct cggcgcttgc
2673361 acctgcaggc ggcgggccag gtcgggacgc acccagtcgc cgccgacggc caccgctcgc
2673421 agcgacgaca gccggccccc gccgacttcg agcagcatgt ccaaccagcc cggcatgaaa
2673481 ttcaacgccg tgacctcgta agtgtcgata agccgggccc aggcgtcggg atcgcggcgc
2673541 tgcgcttcgt cgaccaccac gatcgctccg ccggagcgca gggcggcgaa gatgtccagc
2673601 accgacatgt cgcactccag cgtcgccagg gcaagccagc gatctgcggc gcctagctcg
2673661 aagtgccgga tgaaggtctc cacggtgttc atcgcggcgt cgtgcgccac ctcgacaccc
2673721 ttgggttccc cggttgagcc cgaggtgaac aacacatagg cgagcgcggt gggatcgcta
2673781 ggcccgggca cgaattctgc cggcgcggcg gcaagcacgt cagccagcaa cagcgtcggg
2673841 accggcaccc gcacttggca tggcgggccg caaacgagcg ctaagttgac cgaaccggtc
2673901 gccaggatgc gctccgcgcg gtcgcggggc tggtcgacgc cgatcggcag atagaccccg
2673961 ccggcggcca aaatccccag cacagccgcc acttgttcgc ccgttttcgg acccagcacc
2674021 gcgacggtgt cgccgactcg taggcccgca gcacgcagcg ccgcggccac cgccgatgcc
2674081 tggtcgcgca gttgggcgta gctcaagtcg ccggaactgg cgaacaccgc cggcgcgtcg
2674141 ggctgctgtt gggcctggcg gaaaaacccg tcgtgcagcg cctcggtgct gggggcggcg
2674201 gtgcgaccgt tcagcgccgc gcgcaccgcg cgttgcgcgg cgggtagcgc ggacgggctc
2674261 ggcgcatccc aggcgtcgtc cccggcggcc aaccggagca attcgtcgac ctggtgggtg
2674321 aacatggcgt cgatgacgcc gggtgcaaag accccctcgc ggacatccca gttcaccagc
2674381 acaccgccgt cgaactcggt gacctgggcg tcgagcagca cctggggccc ctgcgaaatg
2674441 atccatccgg gtgtgccgaa ttgctcggtg acgtccgggc agaaaaggtc gccgagcccc
2674501 agcgcgctgg tgaataccac cggtgccagc acctgggtgc cacggtggcg gctgaggtca
2674561 cgcagcacag acagcccggg gtatgcactg tggcctgcgg cgctgcgcag ggcttcctgc
2674621 accgcctgcg cccgcgccgc cgccgtgcgc gcaccggtca gatcgacgtc gagcaacagc
2674681 gaggaggtga agtcaccgac cagcaggtcg acgtctggat gcagggcctg gcgactgaac
2674741 aacggcaggt tcagcaggaa ccgcgacgac gctgaccaac gcgccagcac gttggcaaag
2674801 gccgcggcca gcgtcatcgc cggggtgatg ccgcgggccc gggctcgggc gaacaacgcg
2674861 tcgcgggtct gcgggtctag ccagtgccag cgccgggtgc tgcggcgccg gtcgcgttcg
2674921 ccgccggccc gggtaggcag cgcgggcgga tccggcagct gcgggatgcg ctgcgcccac
2674981 cagtcccggt cggcgtcgcg aaccggttgg ggcagcgtct cctccgcctc gatagcctgc
2675041 cggtattccc ggtaggtgta gcccagtgcc ggcggttcac ggccgtcata gagggccgcc
2675101 aggtcggcca gcaagatgcg gtagctcatc gcgtcagcgg cctgcatgtc caggtcgaca
2675161 tgtaggcggg tgcgctcccc cggtaataac gtcaacgcaa gttcgaatac cgcaccgtcg
2675221 agctgctggt gcgatttggc gtcgcggatc cccgccaacc gctgatcgac gacatccggg
2675281 gccacgtgac gcaggtcggc aacactgatg ggaaagtcgc gagatcccgc cgccggcggg
2675341 atgcgctggg tgccgtcggg caagaactgc acccgcagca tcgggtgccg cagcgccaac
2675401 cgggtggccg ccgcgcggag cctgtccgga tcgacccggg caccatcgaa ctcgacgtag
2675461 aggtgcccag ctaccccgcc gagctgttgg tggtcgtggc ggccgaccca catcgcgtgc
2675521 tgcatcggcg ccagcgggaa aggctcgcct tcctgggata acccggcatc ccctggtgcg
2675581 gcaactgccg tgggcgcgac gccggtgccg gcggacacca gttgggacca ggcctcgatt
2675641 gtgggtgtgg cggccagtgt ggcgaagtcg acggcgatgc ccttccggcg ccagcgcccc
2675701 accagcgaca tcatccggat cgagtccagg ccctgaccaa cgaggttggc gccggggtgc
2675761 agagcatcgg cgcggacacc gagcaactct gcgacctcgg cgcgaatgat ctccgagcac
2675821 gccgtagcat gcaccacaaa ccctcccctg ttagcacagg ctgccctaat tttagtggtt
2675881 accctatctt cgaaccacgc acctgcgcta ccagcccccc tgttaaggag cccacatgcc
2675941 accgaaggcg gcagatggcc gccgacccag tcccgacggc ggactgggtg gctttgtacc
2676001 gttccccgcg gatcgggccg cgtcgtaccg ggcggccggc tattggtcgg ggcgaaccct
2676061 ggacaccgtg ctctccgatg ccgcgcggcg ctggcctgac cgcctcgcgg tggccgacgc
2676121 cggtgatcgt cccggccacg gcggcctcag ttacgccgaa ctcgaccagc gggccgaccg
2676181 ggccgccgcg gcgctgcacg gcctgggcat cacgccaggc gaccgggtac tgctccagct
2676241 gccaaacggc tgccagttcg cggttgccct gttcgcgtta ttgcgggcgg gagcgatccc
2676301 agtgatgtgc ctgcccggtc accgcgccgc cgaattgggc cacttcgccg ccgtcagcgc
2676361 ggccaccggg ctggtggtcg ccgatgtggc cagcgggttc gactatcggc cgatggcgcg
2676421 cgaacttgtt gccgatcacc ccaccctgcg ccatgtcatc gtcgatggcg atccgggacc
2676481 gttcgtgtcg tgggcgcagc tgtgcgccca ggccggcacc ggttcgccgg caccgccggc
2676541 cgatcccgga tcgccagcgc tgctgctggt ctccggcggc accactggca tgcccaaact
2676601 cattccacgc acccacgacg actacgtgtt caacgcgacg gccagcgccg cactctgtcg
2676661 gcttagcgcc gacgacgtct atctggtggt gctggccgcc ggccacaatt tcccgctggc
2676721 ctgcccgggc ctgctcggcg cgatgaccgt cggggccacc gccgtgttcg cccccgatcc
2676781 cagcccggag gccgccttcg ccgccatcga gcgccacggt gtcaccgtca ccgcgttggt
2676841 tccggcactg gccaaactgt gggcccaatc ctgtgagtgg gagccggtga caccgaagtc
2676901 actgcggttg ttgcaggttg gcgggtccaa gctagaaccc gaggacgctc gccgggtacg
2676961 caccgcgctc accccgggcc tgcagcaggt gttcggcatg gcggaggggc tgctgaactt
2677021 cacccgcatc ggcgacccac ccgaagtggt ggagcacacc caggggcggc cactatgccc
2677081 ggccgacgaa ctgcgcatcg tcaacgccga tggtgagccg gtggggcccg gggaggaagg
2677141 cgaactcttg gtgcgcgggc cctacacgct gaacggctat tttgctgccg aacgcgacaa
2677201 cgagcgctgc ttcgatccgg acggcttcta ccgcagcggc gacctggtcc gccgccgcga
2677261 cgacggcaat ctggtggtca ccgggcgcgt caaggatgtc atctgccgtg cgggagaaac
2677321 catcgccgcc agcgacctcg aagaacagct gctgagccat ccggcgatct tctcggccgc
2677381 ggcggtggga ctacctgacc agtatctggg ggaaaaaatc tgcgctgcag tcgttttcgc
2677441 tggagctccg attacgcttg cggagttgaa cggctacctt gaccggcgtg gtgtggccgc
2677501 gcatacgcga cccgaccagc tggtcgcgat gccggcgctg cccacaacgc cgatcgggaa
2677561 gatcgacaaa cgagcgatcg tccgccagct cggcatcgcg acgggtcccg tgacgaccca
2677621 gcgctgccat tgactgacgt caacaagttg aattgactgc gttgcatgac cgacggtgtt
2677681 ccggcccgcg ggtcacttcg atcacgcggc gcggtagcgg tgagctcgat ggtgttgcgg
2677741 cccatcaccg gggcgattcc gccagacggg ccgtggggga tatgggcctc gcgccggatc
2677801 atcgccggac tcatgggcac gttcgggccc tcgctcgcgg gcacccgagt ggaacaagtc
2677861 aactccgttc tgccggacgg acgccgggtc gtcggcgaat gggtgtatgg accgcacaac
2677921 aacgcgatca atgccggacc cggtggcggc gccatctatt acgtacacgg cagcggttac
2677981 acgatgtgtt cgccccgaac ccaccggcgg ctgacatcct ggctgtcgtc attgaccggg
2678041 ctaccggtat tcagtgtcga ttaccgactg gcgccgcgct accgtttccc gaccgcggcc
2678101 accgacgtgc gggcagcctg ggattggtta gcgcacgtat gcggcttagc cgcggagcac
2678161 atggtgatcg ccgcggattc cgcgggtggc catctgaccg tcgacatgct gctgcaaccc
2678221 gaggtcgccg cccgacctcc ggcggcggtg gtgttgtttt cgccgctgat cgacctcacc
2678281 ttccggctgg gcgccagtcg tgagctgcag cgccccgatc ctgtcgtgcg cgctgaccgt
2678341 gcggcccggt cggttgcgct gtactacacc ggagtcgatc ccgcccacca ccggctggcg
2678401 ctcgatgttg ccggcgggcc accgctgcca ccgacgctga tccaggtggg tggagccgag
2678461 atactcgagg ccgatgcgag acaactcgat gccgacatcc gcgctgccgg cggcatatgc
2678521 gagttgcaag tgtggcctga tcagatgcat gtgttccagg ccctgccgcg gatgacgccc
2678581 gaagcggcca aagccatgac ctatgttgcc cagttcatcc gcagtacaac agcacgtgga
2678641 gacctctgaa cgttactggc gtgcaaccag ataaggcgtc aatgtggata gcttttcgca
2678701 agtctcctcg aattcgcgct ctggctccga ttcttcgatg atgccggcgc cggcccgcag
2678761 ccaagtccgc ccgccgacct ggtatgccgc ccgcagcgtc agcgcggcgt ctagcccgcc
2678821 atccgccgaa agcatcacca ccgcaccgga atacagccca cgtgggcact catcgaggcg
2678881 aaagatggcc tcaacgccag ctgctttcgg gattccggat gcagtgacag caggaaaaag
2678941 ggcttccagg gcggccatcc ggtcgctcga tggatccaac cgtgctctga tggtggagcc
2679001 gaggtgctgc acactgccgc gctcgcgcac cgtcatgaaa tcgatgaccg cagcactccc
2679061 tggttcggcg atgtcggtaa tctcctcaag cgaagagcgc actgaaatgg cgtgctcgac
2679121 aatttctttg gagtttgatt ccaggtcatc acgagccagt cggtcaatgg cgggaccacg
2679181 gcccaaggcg cgggtaccgg ccaacggctc ggtgatcacc actccgtcgg cgcgcaccgc
2679241 cgtgacgagt tcggggctgt aacccagagc acggattccg cccaactgca acaaaaacga
2679301 cctcaccggg gtgttgtgcc gacgccccag ccggtaggtc aacggaaagt cgatcgcgaa
2679361 aggcacttcg acacaacggg acagaatcac cttgtggtag cggccggcag cgatttcatc
2679421 gacggctacc gccacccgac ggcggaagcc ggatggatcg tcggagacgt cgacggagcg
2679481 ggactgcggc acctctcgca ccccggtggc gagtaatcgg tcgatggcct cgcggtggcg
2679541 aatcccagca tcgaacaggc gaatctcctt ttcgctcacc atgatccggg ttcggggcga
2679601 aaacacccgg gccagtgggg tgtgcggcgc cagccgctgc tgcaacccat agcggtgcac
2679661 gccgaattcg aaggcgaccc agccaaaagc ttgatcggtt tccagcaaca gccgatcgac
2679721 ggcttcgccc agggccgctc ccgggcgacc cgaccattgc tgtcgccgcg taacgccatc
2679781 acggatgacg cgcagttcgt cgctgtctag ctccaccatc gcctgcacac cggcggccag
2679841 gacccattgg ccgtcgcact cgtagagcag gtaatcctcg tcgacggact cggtaaccac
2679901 cgccgccagc tccgctgcca ggtcggcggg gttgacaccg gcgggcatcg ggatggacga
2679961 cgacgcggtg ctgacggcgc ctgtcgcgac gctgagctcg gacacagcta gtaaatgtag
2680021 cctaacctac ttaatgggtc gcagcccccc ggggtcgtcg catgtccaac gtgctcgact
2680081 ggaagaaaat gctcgtcggg agcaaatggc accagccggg gcggcgacag gacccaccca
2680141 cggccggacg gtccgcggac tgcgtttcgc agcgtaatca tttccgcagg cagaggcggt
2680201 cgcggccggt gctcgccggt taccatgccc gccaactcac gcacacgaaa tcgtgaaacc
2680261 tttgccaacc gtttactggc tagctacaaa gcaaggtttt gccttcgccg gaattctcct
2680321 aacatcactc actaaccacg tagaccatcc ggtcgacgac gtagtcgcgg tacgcgtggc
2680381 tcgccaagct cggtatgtcc gctgggtctg cccaggcatc gcccgatcgt tagccagtca
2680441 acagagagga cccgacgatg ttcgtaatcc ggctcgccga cggcgaagaa gtccacggcg
2680501 agtgcgacga gctgacgatt aacccagcaa ccggcgtcct cacggtctgc cgggtcgacg
2680561 ggttcgagga aaccaccacg cactactcgc cgtcggcgtg gcggtcggtg acacaccgca
2680621 agcggggggt cggcgttaga ccatccctgg tctcaactgc tcaataagcc cgagccacac
2680681 tttctagatt cgacttgata ttcctggtcg ctcccctgac gctgggtgct tcctggatcg
2680741 ccgcaccagg tatgggaggc gccaatgctg catgagttct gggtgaactt cactcacaac
2680801 ctgttcaagc cgctgctgct gttcttctat ttcgggttct tgatcccgat cttcaaggtg
2680861 cgattcgagt tcccctatgt gctctaccag ggcctaaccc tgtatctgct gctggccatc
2680921 ggttggcacg gcggcgaaga actcgccaag atcaagccgt ccaacgtcgg cgccatcgtt
2680981 gggttcatgg tggttggctt cgccttgaac ttcgtgatcg gcaccttggc atacttcctg
2681041 ctgagcaagc tgaccgccat gcgccgggtc gacagggcga cggtcgccgg ctattacggg
2681101 tcggactcgg cagggacatt tgccacctgt gtagcagtcc tgaccagcgt cggcatggcc
2681161 ttcgacgcct acatgccggt catgttggcc gtcatggaga tccccggctg cctggtggcg
2681221 ctgtatctgg tggcgcggct gcggcaccga gggatgaacg aggcggggta catggccgac
2681281 gagcccggct acaccacagc ggcgatgatc ggagcggggc ccggcacgcc cgcccggccc
2681341 gctcacagcg acagcctcac ggcccaagcc gagcgcggca tcgaagaaga gttggagctc
2681401 tcgctggaaa agcgcgagca tccaaattgg gatgaagacg gcgtcaaaga cagcggcacg
2681461 aatgcgtcga tcttctcacg cgagttgctg caggaagttt tcctcaaccc ggggctcgtt
2681521 ctcctcttcg gcggcatcgt catcggcctg atcagtggac tgcagggaca gaaggtccta
2681581 cacgacgacg acaacttctt tgtggcggca ttccagggcg tactttgcct gttcctgttg
2681641 gagatgggca tgacggcgtc gcgtaagttg aaggatctgg cgtcggcggg cagtgggttc
2681701 gttttcttcg gcctgctggc accgaatctg tttgcgacgc ttgggatcat cgtggcccac
2681761 ggctacgcat acgtcactaa caacgacttc gcgccgggca catatgtgct gttcgcggtg
2681821 ctctgcggcg cggcgtccta tatcgccgtc ccggccgtgc aacggcttgc gatccccgag
2681881 gccagtccga ccttgccgct ggccgcgtcg ctgggtttga cgttctccta caacgtcacg
2681941 atcgggatcc cgctgtacat cgagatcgcc cgcatcgtcg ggcaatggtt ccctgccacc
2682001 ggggcttcga tcggttagcc cagcagagtg cgcaccaccg cgtcggccag caatcgcccc
2682061 cggccggtga ggaccagtcg gtcgccgtgg tagtccagca atccgtcggc caacaccgcc
2682121 tcggcacgtt cccgttcggc agcccctagc cgggcgagcg gtagcccctg gcgcagccgg
2682181 accttcagca acacgtcttc ggtgtgcaaa gcgtcggcgc ccagctgctc gaagcccgct
2682241 accggcaacg tcgccccggc cagtatctcg gcgtaagtgt tggggtgctt gacattccac
2682301 cagcgtgtca cgccaatgta gccgtgcgcg cccggacctg cgccccacca ctggccaccg
2682361 tcccaataac ccaggttgtg ccggcactcg ccgcccggtc gacaccaatt ggacacctcg
2682421 taccaggcaa acccggccgc cgacagccga gcatcgacca actcgtagcg atgcgccagc
2682481 acgtcgtcat cgggcgcggc cagctcacca cgccgaaccc ggcgagccag tgccgtgccg
2682541 tgctcgacga ccaaggcata cgcggacaca tgatccacac cggcctgcac cgcggcgtcc
2682601 actgagcgca ccaggtcgtc gtcggactcc cccggggttc catagatcag gtcgaggttg
2682661 acgtgtgtga agccctccgc tatcgcctcg gtggccgcgg ccgccgcccg gcccggcgag
2682721 tgcacccggt ccaaggttgc cagcaccctc ggggccaccg actgcatgcc gagcgacacc
2682781 cgcgtgtaac cggccgcgcg gatcgtggcg aagaactccg gccacgtcga ctcggggttg
2682841 gcctcggtgc tgacttcggc gtcgggcgcc agcacaaagt ggtcccgcac catgtccagc
2682901 aacgtggcca ggcgctcccc cccgagcagc gatggcgtcc cgccacccac atacacggta
2682961 tgcaccgtcg gtgcgtccag cttggcggcc gccagttcga gctccgcccg cagcgccagc
2683021 agccaacggt ccgggctgac gccacccagc tgggccgggg tgtaggtatt gaagtcgcag
2683081 tacccgcaac gggtcaggca gaacgggacg tgcaggtaga ccccgaacgg ttgtccgggc
2683141 atgggcgcca ggccgggcag ctcaactggt gcctgccgaa ataccatgcc aaatcatcgc
2683201 atagcgcgta ccagctaggg tggccagcaa tgtaacgcag gcacacctca atcgtccctg
2683261 ctccccgaac aacctccagt ctcggccgcg aggaacgtca ggatgtgggt gagcgagccc
2683321 agcggtgcgt ctccctgact acaagaacta catttcggcc acgcacccgg gccttgggtt
2683381 ttcataatgt tgtctgcgac ctcgatctgt tgctggggac tcgcggccgc cggcgacccg
2683441 acaccaccgt tggaatccca cgtcgcctgg ctgatctgca gaccaccgta taacccgtta
2683501 ccggtgttgg ccgcccaatt gccgccggat tcgcattgcg cgatggcgtc ccaatcgatg
2683561 tcgtcggctt tcgagctgat ggtggacaga cccaacaacg cgacaaacat ggtcgcgaca
2683621 acggcggttt cgatgaacac cgtgcatacg atcctggcgc acctgtcacg tggtcggcca
2683681 gcacccgcag tagtaagcaa acccggtgtc atagcagctc caccttgctg gccagccagc
2683741 ggccgttcac cttgtccatg atcaccttga tccgactgcg gtcgatctgc ggcgttgggc
2683801 tgttccggtt gctgaccgac tggtcgatga acatcaggac cactaccttg ttcgtggtgg
2683861 ctgatttgac cgacgccgcc acgacggtcc cgtgggtggc cacccgattg tcggccagca
2683921 gttggcgaag gtgcgcactg gatttgccgt acttatcttt gaactcgccg gtcgaaccct
2683981 cgagaatgtc cctcatgttg tggtcgatcc gctcacagtc catggtggcc agcttgacga
2684041 catagctgcg tgcggcctgc agtgcctggc cggcggcgac gtctgtctga tgcttctcaa
2684101 agagcaccca tccgcaccat ccagacccgg ccaacgacac aaccaccgcg acggcgccaa
2684161 cccagccaat caccgatctg gttaaccgac cgcggccggg agtttcggcc ggttcgccgg
2684221 tgccgcctgg ctcacttgca ccgtggcccc ggccgaagat ggccattctg cgcacgattg
2684281 acctcgatca ctatccgcta agacaactat ctcagtagtc atatttggtc acatctgtca
2684341 ctcctgtcaa cgtcaggtgc gcgtctccca gcggattccc gggtcggcct atccatccat
2684401 ccaggcttgt tgcgtagttt tgatcatcgt gaaaagaaat ttgaccaggt cgcgcagctg
2684461 cacgccatcc atggcagaat gtcaccgtga ccgccgccaa gaacccgcgc cccgatctgc
2684521 gaatcgcgct ggtggctcgg cggcacatcg acctcaagcg ggtctgcagc tgtggctgtc
2684581 ggccttgacg ccgtaaaccc agcccacctg tatctgcagc cggcgaccgg atctgcccct
2684641 cccggaacaa gcggcgttta gcgcgtccta ggtcggcgat gtccgcgaag gagaaccccc
2684701 aaatgaccac tgcacgtccc gccaaggctc gaaatgaggg ccagtgggcg ctgggacatc
2684761 gcgagccact caacgccaac gaagagctga agaaggccgg caacccgctc gacgtgcggg
2684821 agcgcatcga aaacatctac gccaaacagg gtttcgacag catcgacaag accgacctgc
2684881 gagggcgctt tcgctggtgg ggcctgtaca cccagcgtga gcagggctac gacggcacct
2684941 ggaccggtga cgacaacatc gacaagctcg aggccaaata cttcatgatg cgggtgcgtt
2685001 gcgacggcgg cgcgctctcg gctgccgcgc tgcgcacgct gggccagatc tcgacggagt
2685061 tcgcgcgcga taccgccgat atctccgacc ggcagaacgt gcaataccac tggatcgaag
2685121 tggaaaacgt ccctgaaatc tggcgacggt tagacgatgt cggactgcag accaccgagg
2685181 cgtgcggtga ctgcccgcgg gtagtgctgg gctcgccgtt ggccggcgag tcgctcgacg
2685241 aagtgctcga cccgacctgg gcgatcgagg agatcgtgcg tcgctacatc ggcaagcccg
2685301 acttcgccga cttgccgcgc aagtacaaga ccgccatctc tggcctgcag gacgtcgcgc
2685361 acgagatcaa cgacgtcgcc ttcatcggcg tcaaccatcc cgagcacgga ccaggcctgg
2685421 atctgtgggt gggcggtgga ctgtcgacca acccgatgct ggcccagcgg gtcggcgcct
2685481 gggttccact gggcgaagtg cccgaggtgt gggcggcggt cacctcggtg tttcgcgact
2685541 acggctaccg gcgactgcgc gccaaggccc ggctgaaatt tctgatcaaa gactggggca
2685601 tagcgaagtt ccgcgaagtg ctcgaaaccg agtacctcaa gcgtccgctg atcgacggtc
2685661 cggcccccga accggtcaag catccgatcg accacgtcgg ggtgcaacga ctcaagaacg
2685721 ggctcaacgc cgtcggagtc gcccccatcg ccgggcgggt atcgggcacc atcctcacgg
2685781 cggtcgccga cctgatggcg cgggccggtt ccgaccggat ccggttcacc ccctaccaga
2685841 agctggtcat cctcgacatt ccggacgcct tgctcgacga cttgatcgcc ggtctggacg
2685901 cgctggggct gcagtcgcgc ccgtcgcatt ggcgccggaa cttgatggcg tgcagcggga
2685961 ttgagttctg caagttgtca ttcgccgaaa cccgggttcg agcacagcat ttggtgcccg
2686021 agctggaacg ccggcttgag gacatcaact cgcagctcga cgtaccgatc accgtcaaca
2686081 tcaacggctg cccgaactca tgtgcgcgaa ttcaaatcgc cgacatcgga ttcaagggac
2686141 agatgatcga cgacggacac ggcggctccg tcgaaggctt ccaggtgcat ctgggcggac
2686201 acctcggcct ggatgccgga ttcggccgca aactgcgcca gcacaaggtc accagtgacg
2686261 aactcggcga ctacatcgac cgggtggtgc gcaacttcgt caaacaccgc agcgaaggtg
2686321 aacgcttcgc gcagtgggtc atccgggccg aggaggacga cctgcgatga gcggcgagac
2686381 aaccaggctg accgaaccgc aactacgtga gctggccgcg cgcggagctg ccgaactcga
2686441 cggcgccacc gccaccgaca tgttgcgctg gaccgacgaa accttcggcg acatcggcgg
2686501 cgccggcggc ggcgtgagcg gacatcgcgg gtggacaacg tgcaactacg tagttgcttc
2686561 caacatggct gatgcggtgc tggtggatct ggccgccaag gtgcgaccgg gcgtaccggt
2686621 catctttctt gataccggct accacttcgt cgaaacaatc ggcaccagag atgcgatcga
2686681 gtccgtctat gacgtccggg tgctcaatgt cactccggag cacacagtgg ccgagcagga
2686741 cgaactgctg ggcaaggact tgttcgcccg caacccccat gaatgctgcc ggttgcgcaa
2686801 ggtcgttccc ctgggcaaga cgctgcgtgg ctactccgcg tgggtgaccg ggctacggcg
2686861 ggtcgatgca ccgacccggg ccaatgcccc gctggtcagc ttcgatgaga cgttcaaact
2686921 agtgaaggtc aacccgctgg cggcgtggac cgaccaagat gtgcaggaat acattgccga
2686981 caacgacgtg ctggttaatc cgcttgtgcg ggaaggctat ccgtcgatcg gttgcgctcc
2687041 gtgcacagcc aaacccgccg aaggcgccga cccgcgcagc ggacgctggc aggggctggc
2687101 caagaccgaa tgcgggttgc acgcctcgtg accgcgccgg cgacgatgca gagcgcagcg
2687161 atgctgagga gcggcgccat cgaagcaccg ccggcgacga tgcagagcgc agcgatgcgg
2687221 tgggggcacc tcccgcttgc ggaggagagc ggcaccatcg cgcctcagct cgtcctcacc
2687281 gcacacggca gcaaagatcc gcgatcggcc gccaacgcac gggctatcgc gggccggctg
2687341 gcgcgcatgc ggcccgggct cgacgtgcgg gtcgcgttct gtgagctcaa ctcgcccaac
2687401 ctggtcgacg tgctcaaccg ctgtcgagga gcagctgtgg tcaccccgct gctgctggcc
2687461 gatgcctacc atgctcgcgt cgacatccct gcccagatcg ccagctgccg cgttggtcac
2687521 cgggtacgcc aggccagtgt gctgggtgag gacattcggc tggtgtcagc gctgcatgag
2687581 cgcctcaccg agctgggggt ttcgccgttc gaccacacac tgggggtggt cgtgctcgcg
2687641 atcggctcat cgcatcccgc ggccaatgcg cgcacctcga cggtggcgtc aaggctggcg
2687701 gaggggaccc agtgggccgc ggtgacgacc gctttcatca cccgaccgga ggcttcgctg
2687761 gccgatgcca ccgatcggtt gcgacgccac ggtgcccgtc ggatggtcat cgcgccatgg
2687821 ctgctcgccc ctgggatact gtctgaccgg gtacgcggat acgcacggga agccggcatc
2687881 gcgatggcac aaccgctggg tgcacacccg atggtggccg cgaccatgtg ggatcgctac
2687941 cgacaagccg tggccggtcg gatcgcggcc taggtcttct cgaaggtctg ctggaacgga
2688001 tgtcctctgg tgagtgtttg gttgcgagcg ggcgccttgg tggctgcagt gatgctgtcg
2688061 ctgagcggat gtggcggctt ccacgcgggt gcgccaagca cggccggtcc gtgcgagatc
2688121 gtccccaatg gcacgccggc gcccaagaca cccccggcta ccgtgccttc gtcgcgcaac
2688181 ctcgcgacca accccgagat cgccaccggc taccgccggg acatgaccgt ggtgcggacc
2688241 gcccactatg cggcagccac cgccaatccg ctggccactc aggtggcctg ccgagtattg
2688301 cgcgacggtg gtaccgccgc cgatgccgtc gtggccgccc aggcggtgct ggggttggtc
2688361 gaaccgcaat cctccgggat cggcggcggc ggatatctgg tgtacttcga cgcccgcacg
2688421 ggctcagtgc aggcctacga cggccgtgag gtggccccag cggccgccac cgagaactac
2688481 cttcgctggg tcagcgacgt cgaccgcagc gcgcccaggc ccaacgcccg agcctcggga
2688541 cggtcgatcg gagtaccggg catcctgcga atgctggaga tggtgcacaa cgagcacggg
2688601 cgcacaccct ggcgcgacct cttcggcccc gcggtaacgc tggccgatgg cggttttgac
2688661 atcagcgcca ggatgggcgc ggccatctcc gacgctgcgc cgcaactgcg agacgacccg
2688721 gaggctcgca agtatttcct caatcccgac ggcagcccga aacccgcggg aacccggctg
2688781 acgaaccccg cgtactcaaa aaccctgtcc gccatcgcct ccgccggcgc caacgccttc
2688841 tattccggcg acattgccca cgacatcgtg gcggcggcga gcgacacatc gaatggccgc
2688901 acgccgggcc tgttgaccat tgaggacctg gcgggttacc tcgccaagag acgccaaccg
2688961 ttgtgcacga cctatcgcgg ccgggagatc tgcggcatgc catcgtcggg tggcgtcgcc
2689021 gtggccgcaa ccttgggcat cctcgagcac ttcccgatga gcgactacgc gcccagcaag
2689081 gtcgacctca acggcggtcg cccgaccgtg atgggggttc acctgatagc ggaggccgaa
2689141 cggctggcct atgccgaccg cgaccaatat atcgctgacg tcgattttgt ccggctgccc
2689201 ggcggctcgc tcaccacgct ggttgacccg ggctacttgg cagcacgcgc cgcgctaatc
2689261 tcgccgcaac acagcatggg cagcgccaga ccgggggact tcggcgcacc gacggccgtc
2689321 gccccgccag tgcctgagca tggcaccagc cacctcagcg tcgtcgattc gtacggcaat
2689381 gcggccacgt tgacgacgac ggtggaatct tcgttcggct cctaccacct ggtggacgga
2689441 ttcatcctca acaaccagct gagcgatttc agcgccgagc cacacgctac tgacggatca
2689501 ccggtggcta accgggtcga gcctgggaag cgaccgcgca gttcgatggc accgacgttg
2689561 gtgttcgatc actcgtcggc ggggcgcggt gcgctgtacg cggtgctcgg ttctccgggc
2689621 ggctccatga tcatccagtt cgtcgtgaaa acacttgtgg cgatgctgga ttggggtctg
2689681 aatccgcagc aggcggtttc cctggtcgat ttcggcgccg cgaactcgcc gcacactaac
2689741 ctcggcggtg agaatcccga gatcaacact tccgacgatg gtgatcatga cccgctggtg
2689801 caaggcctgc gcgcgctggg gcatcgagtt aatcttgccg agcaatccag tgggctctcg
2689861 gcgatcaccc gcagcgaggc gggttgggcc ggcggcgccg acccacgccg cgaaggcgcg
2689921 gtcatgggcg acgatgcctg agccgttcgc cggcgggcgg ccaaacgaac gcggaccact
2689981 tcgagccgat aattttgccg gccctctcgg gctttgtctg cggttttacc ggctcggtgc
2690041 attcgcgcgc tagccgatag ggtctatcgc catgtccggt gccacggtgg gtgcgcgcga
2690101 aatcaccatc cgcggagtcg tcctgggcgc attgattacc ttggtgttca ccgcggccaa
2690161 cgtgtacctg gggctaaggg ttggattgac attcgccact tccataccgg ccgcggtgat
2690221 ctcgatgggc gtgctgcggt tgttcgccaa ccactcagtg gtggagaaca atattgttca
2690281 gacgatcgcg tcggcggccg gcacgctgtc gtcgatcatc ttcgtgttac cggcactgct
2690341 catgatcggc tggtggagcg ggtttccgta ctggacaacg gcggcggtgt gtgcactggg
2690401 cgggatcctt ggcgtcatgt actcaattcc gttgcgccgc gcactcgtca ccggatcaga
2690461 cctgccgtac ccagaaggcg ttgccggagc cgaggttctc aagatcggtg actccgcacg
2690521 ggagatggag cacaaccgta ggggaattgg ggtaatcgcc ctgggcgcgg cagcggcggc
2690581 gggatatgca ctgctggcat ccctgcgggt gatcaacaac tcactgtcgg ccaccttccg
2690641 agtaggttcc ggtgcgacga tgatcggtgc cagcttgtcg ctggcgttga tcggcgtcgg
2690701 tcatcttgtt ggcgtcaccg tcggtgtcgc aatgatcgtc ggattggcta tcgcctttgg
2690761 ggtaatgctg ccaatacgga cagccggcca actgccgccg gacggggact acgccgtcgc
2690821 cgtcgccaga attttctcga cggacgtgcg gttcatcggg gcgggcgcca ttgcggtggc
2690881 ggccgcctgg acgttcttga agatcctggg gccgattctg cgtggcatcg ccgacgccgc
2690941 ggtctcagct cgaacccgac gccgagggca agcggttggc cagaccgagc gcgacatccc
2691001 gatccacatc gtggccatgg tggttcttct ctcgctgatc ccaatcggat ggctgctcgc
2691061 ggactttacc gacgggacac cgctcgatga ccgcaggccc ggcgccatcg ccgccggggt
2691121 actgctcgtc ttggtcatcg ggttgatggt cgctgcggtc tgcggttaca tggccgggtt
2691181 gatcggctcg tcgaacagcc cgatctcggg cgtgggcatt ctggtggtgg tgctggccgg
2691241 tctgctgatc aagactgcgt atggtccggc caccggctcg cagattccgg ccctggtggc
2691301 ctacaccgtg tttaccgctg cattggtctt cggcgtggcg actatttcca acgacaatct
2691361 gcaggacctc aaaaccggcc aactcgtcgg cgctacccca tggaagcagc aggttgcact
2691421 gatcatcggc gtgctcgtcg ggtcggtggt gatggcgccg atcctgcagc tgatgcaggc
2691481 tggattcggg ttccaggggg cgccgggcgc aacggccaac gcattggccg ccccgcaagc
2691541 cgcgctcatg tccgcgctgg ccaagggagt atttggtggc tcgctgaact ggtcgctggt
2691601 cggtgtaggg gccttgaccg gcgtgatagc ggtcgcgctc gacgagacac tggccaagac
2691661 gacaaccaac cttcggctgc cgccactagc ggtgggtatg ggtatgtacc tgtcggccgc
2691721 actgacgctg atgatcccga tcggcgcatt cctcgggcgg atctatgact cctgggcgcg
2691781 gtggtctggg gatgacgacg agcgcaagaa acggttgggc gtcatgctcg cgacgggcct
2691841 gattgtgggc gaaagcctat acggggtgct ctttgccgtc atcgtcgcga caactggcaa
2691901 agaggagccg ctggccatgg tcggcgacgg attcaggttt gcctcccagc cgctgggagc
2691961 catcgtcttt gccggcctcc tcgcttggct ctaccagcgc acccgggtca cagcgtcgta
2692021 ccggctggca gcgccggccg gcagctccaa gccactgccc gatttgcctg ggtaaccgca
2692081 ttgcgcccga ggggtccggc ttttcacagc aacttcacgg ttgacatcca ccttggctcg
2692141 cagctctgcg aggcagcctg aggtgacaaa gccggcggcc cgacacatgc agccgagttg
2692201 gctggctcgg aagggggaca gagttgacca tgacagcgag tgtggccaag gtgacagctg
2692261 cacgcccgga gccaagcgcg gcgtgggctg aagcccggcg gcgggtacgc caacgccgcg
2692321 aggacatgct gcgccatcct gcatttctgt ccaagcagct ccctgccgaa ccagcagacg
2692381 acgacggcgt cgcggccgtc tacgacatcg cgattgcgcg tcggcgccga cctgcttgag
2692441 cgggtcccgg cgggtcaacg tcggcggctg ccgggtaaac cggcaatcga cgaccgggcc
2692501 ttggcgggcg cgtcgcgttc tgccagctga actcgccgag cctggtcgat gtgcctgggc
2692561 tggtgcccgc gatgcccttg gacgcgctcc ggccggcgag acagccgacg agtggcttgg
2692621 gcgaatgcgc cacgatgcgt cggccagagg cgggtaacga gaaggtggcg gtgatctggg
2692681 aaagcctgga tgtcgttccc cccgagtcgc tatagtcaac tgcgccgatg ggtcaatgct
2692741 ggccaggcga tgctctggtc gacatggctt agcaatcctg acattttgga ggtgccggat
2692801 gtcgttcctg attgcttcgc cggaggcgct agcggcgaca gccacatatt tgacaggtat
2692861 cggttcggca atcagcgcgg cgaacgcggt cgcggccgcc ccgacaacag agatcctggc
2692921 ggcggggacc gacgaggtgt ccaccgccat ctcagcgctg ttcggcgctc atgcccaggc
2692981 atatcaggcg ctcagcgccc acgtggcggc atttcacgac cagttcgtgc ataccttgac
2693041 cgccggtgcc ggctcataca tggccgccga ggccgccgcc gcctcgcctc tgcaggcttt
2693101 gcagctggag ctgctcaacg ccatcaatgc acccaccctg gcgctgttgg gacgcccgtt
2693161 gatcggcgac ggcaccgatg cggcgccggg gagcgggggg gccggcgggg ccggcggcat
2693221 cttgatcggc aacggcggga ccggcggcgc cagcgactta gccgggaccg gccgcggcgg
2693281 ggtcggcggg gcgggcggcg ccggcgggct cttcggcatc ggcggcgccg gcgggggctg
2693341 cgggtccgcg gtggcgatcg ggggtgacgg cggggctggt ggcgccggcg gcgtgttcag
2693401 cggcggcggc gccggcgggg ccggcgacgc catcgggggt agcggcggcg cgggcggcac
2693461 cggtgggctg ttgggtggtg gcggcggcgc gggcggcgcc ggcggcgccg gcggcaatgg
2693521 cgggggcgcc agcaacagcg caagtatcgg gggtgacggt gggtccggcg gcgcgggcgg
2693581 catgctctac ggtgccggcg gcgtcggcgg caacggcggg gccgcggtcg ctatcggggg
2693641 tgacggcggg gccggcggca gggccggagc gatcggcaac ggcggtgacg gcggcaacgg
2693701 cgggacttcc aacacccccg gcggtagcgg cggcgacggc ggcaatggcg ggaacgccgg
2693761 actgatcggc aacggcggta acggcggcaa cgccgagatt gtcatctccg gcggtagcgt
2693821 cgccggcacc ggtggcaacg gcgggttgct gttgggcttc aacggcacga acgggctgcc
2693881 gtagcgggcg agcccgccgg cctctggatc acgtcgatgt gactttgacc cgttccacgc
2693941 cggcatcgtc gacgcccgat acgccaccgg caatcggcgg cacccgggtg gcacgcacgt
2694001 agacggtgtc accctcgcgt agggccagcg cctcggcatc gccgcgggtg atctgggcgg
2694061 tgaaggcccc gccggtggcc gcgctggtca actccacgcg gacctcgaag cccagcacca
2694121 ccacccgatc cacaacagcc cgtagcacac cggtggaccc ggcggtgccg tcagcggcgg
2694181 ccacggccat attgggagtc cggccgaccc ggatgtcgtg cgggcgcacc agggagccgt
2694241 tcaacgtgga aaccgctccc aagaaggaca tcacgaaggc gttcgccggg gcgtcgtaaa
2694301 cgtcggtcgg ggatccgacc tgctcgatac ggcccttgtg gagtacggcg atgcggtcgg
2694361 ccacatccag cgcttcggcc tgatcgtggg tgaccagcac cgtggtgaca tgcacctcgt
2694421 cgtgcaggcg gcgcagccag gcacgcagct cttcgcgcac cttggcatcg agtgcgccga
2694481 acggctcgtc gagcagcagc acctccggat cgaccgccag cgccctggcc agcgccatcc
2694541 gctgtcgttg cccaccggag agctgattgg ggtagcggct ctgaaatccg ctcaggccca
2694601 ccacctgcag cagattgtcg accttggcct tgatctcggc cttggggcgc ttacggatct
2694661 tcaacccgaa cgccacgttg tcacggacag tcaggtgttt gaacgccgcg tagtgctgga
2694721 agacgaatcc gatgccacgc cgctgtggcg gcacccgggt gacgtcgcgg ccgttgatcg
2694781 tgatggttcc ggtgtccggt tggtcgaggc cggctatggt gcgcaacagc gtcgacttgc
2694841 ccgaaccgct ggggcccaac aatgcggtca gcgaaccggt cggtacgacg aaatccacgt
2694901 ggtcaagtgc gacgaagtcg ccgtagcgtt tggtggcgtc ggccacgacg atggcgtagg
2694961 tcattttcac cgtctccttc tcagccctcg ctgaccgctc gtgcccggcg ggcgtctagc
2695021 accatctgga cgatcagcac caccacggaa accgccatca gcagcgtcga cagcgcgtag
2695081 gcaccgtact cggccccacg gtggtagcgg tcggagacca agagggtcag tgtttgcgat
2695141 gtccctggaa ggttcgacga gacgatgatg accgccccat attcgccgag ggttcgagcg
2695201 acggtcaata cgatgccgta cgtcaggccc caccggatgg agggcagcgt gattcgccag
2695261 aatgtctgcc accaaccgga acccagcgtc gccgccgcct gctcctggtc ggtgcccaat
2695321 tcgtgcaata cgggttccac ttcgcgcacc acgaatggac aggtgacgaa catgctgcca
2695381 agcacgattc ccggcagccc gaagatgatc ttgaagccaa ggtcctgctc gacgaagccc
2695441 agggcgccgg ccgatcccca cagcaagatc aacgagacgc ccacgatgac gggtgaaacc
2695501 gcaaaaggca gatcgataat cgcctgcaag acgcccttgc cgcggaaccg gttgcgggcc
2695561 agcaccaatg ccgtcgtgac tccaaagatc acgttcagcg gtaccacgat agccaccacc
2695621 agtagcgaca ggttcagcgc tgatatcgcc gccggggtac tgatccaggc gtagaactgg
2695681 ccaaagcccg gttcgaaggt ccgccacagg atcagcgcta ccggaacgat caacagcaca
2695741 aagacgtacc ccagcgcgac cgatcggacg aggtagcgag ccgccggcaa ggaggtcatg
2695801 cggccatctc ctcacgtttg gccgcacgcg cgccgacgac acgtaggatg agcagcacaa
2695861 tgaacgaaat cgagagcaat acaaccgata tcgcggccgc tccggtgcgg tcgtcgttct
2695921 cgatcagggt gcgaatccat tgcgaggaca cctcggtctt gcccggcacg gccccgccga
2695981 tcagaaccac cgaaccgaac tcgccgatag cgcgcgaaaa cgccaggccc gcaccggata
2696041 acaatgccgg cgtcagcgac ggcaacacca ccgaagtgaa gattttggca ccattagcgc
2696101 ccagcgacgc cgccgcctcc tcggtctcgc gatcgatttc cagcagcacc ggctgcacgg
2696161 cgcgcaccac gaacggcaat gtgacgaacg ccaacgccac cccaacaccg gtcgcggtgt
2696221 gttgaaaatg aagccccacc gggctgttgt tcccgtacag tgccaacatc accaggctgg
2696281 cgacgatggt gggcaacgca aacggcagat cgataatcgc atcgacgatc cgcttgccag
2696341 cgaagtcgtc acgcaccagc acccaggcga tcagcaagcc gaacaccagg ttgatgaccg
2696401 tgactgcggt cgaaatcgtc agcgttaccc ggaacgactc catcgcggca tgcgacgaga
2696461 ccgccagcca gaaggcccgc caaccaccgc ccgcggcctg ccagacgatg gcggccagcg
2696521 gcaacagcac gatcaccgaa agccacacca ctgccatacc gacccgaacg gaaggggggc
2696581 ccgcggggcc ggaaaggcgc gcgcggaact gcggcgcgcg gcgttcgccg accaacgatt
2696641 ccgtcatccg gtggcccgca gataaatctt ggtgatgctg ccggtcgcct tgtcgaacag
2696701 ctgaggatcc acgctgcccc agccaccgag gtcggcgatc gtccacagtt tcgccggcac
2696761 cggaaacagg tcggcaaaat cggcggcgac cgccggatcg accggccgga aaccggcctg
2696821 cgcccataac ttctgcgcct gcacggtgta ctggaagttt ctgaatgcgg tcgccgctcc
2696881 aaggtgtgtg ctggtcgcca ctacggccaa cggattttcg atcttgaacg tctgcggcgg
2696941 ggtgacgtgc tgcaccggtt tgcccgcccg ctcggtggcg atggcttcgt tctcgtagct
2697001 gatcaacacg tcaccgctgc cctggacaaa aacatcggtg gcttcccgcc ccgacccggg
2697061 gcgcaatttg acgtgttcat tcaccaatgt attgacaaag tcgatccccg cttggttatt
2697121 ccggccaccg tcacttttcg cggcgtaggg ggctagcaga ttccacttgg cagaacccga
2697181 actcagcgga ctgggcgtga tgacctcaat acccgggcgc aacaggtcat cccaatctct
2697241 gatgttcttc gggttacccg cgcggaccac aaacgtcacc accgacccga acgggatgcc
2697301 cttggtggca tcggcgtccc agtccttgtc aaccttgccg gccttgacca ggcgagcgat
2697361 gtccggttcg accgagaagt tcaccaggtc ggccggttta ccgtcggcaa caccgcgcga
2697421 ctggtcggcc gacgcgccat atgaggtaat cacctggact ccccggccct gttcggaagc
2697481 gttgaacgcg ggaatcaccg cactccagcc gggttccggg acggcgtagg cgaccagggt
2697541 gatgctcgta tgcgcacggt ccggtcccgc acggccgacc acgtcgctgg gaccgccatg
2697601 acaccccacg ccgataccgg cgatcaatgc gcacaccacc ccggcaggga taatgtgccg
2697661 ccagcgggat gcgctagcga tgcagctcgc ttcagaaagc gtcaaggaga gcattggcga
2697721 ccttccggtg cgggactttg gacaacgttc ccgtagcggc ggaaaggcga tcgctgaaca
2697781 ttgcaggact cacgaactcc acatcagacc gcgcacgggt ggggagtcag cgacaacagt
2697841 gcaggttggc cgcagcgccg caaacgagcg cgccgacata gcgccccgaa aaacccgatg
2697901 ctgcgtgcac gtggcgaagc ctaacagaat tcggctggcc gaccagttgg cgcgcagctc
2697961 aatgggtgag aagccaggtc acgatcacca gcgcaaccag cgtgaccaga accaacgtga
2698021 cgtgcgacct cggcatccgg gctacctggg cgcctgatcg gggcggcggg cgcggcgaat
2698081 caactgaatg acccggccga gcagggcatc cagcaatgcc gcggtgaaat aggccaaagc
2698141 cagcacgacc ggcatgactg ccaacgcctg cagcgcgaac gggagtccgg acagccacag
2698201 ctcgacgccg tcccaccaac tcaggaaccc gttcatcggg cccacactat agcgccggca
2698261 ggcaaaaccc caggtgtgtc gcgattacgg tgaccgccga cgccaaaccg cgacacggca
2698321 cacggctgct aggcccacct gagcacgcac ccaactacgc cgggcgccgg gcgtgaagtg
2698381 gacgccgagc aagtcgacag atgatgatgt cggcatggtc ctgcacgctc aaccccccga
2698441 ccaatcgacc gaaacagccc gcgaggctaa agcgttggcc ggggcaacgg acggggcaac
2698501 ggccacatcc gcggatctgc acgcacccat ggctctatcg tccagttcgc cactgcgcaa
2698561 cccgtttccg ccgatcgccg actacgcgtt cttgtccgat tgggaaacga cgtgcctgat
2698621 ttcgccggcg ggttcggtgg agtggctgtg tgtgccacgg ccggactccc ccagtgtgtt
2698681 cggcgcgatc ctggaccgca gcgccggcca ttttcgtctg ggcccctacg gtgtttcggt
2698741 gccttcggcg cgacgctacc ttccgggcag cctgatcatg gagaccacct ggcagaccca
2698801 taccggctgg ctgatcgtgc gagacgcgct ggtgatgggt aaatggcacg atatcgaacg
2698861 gcgatcgcgg acccaccgcc gcaccccgat ggactgggac gccgagcaca tcctgttgcg
2698921 cacggtgcgc tgcgtcagcg gcaccgttga actgatgatg agctgcgagc cggcgttcga
2698981 ctatcaccgc ttgggcgcca cctgggaata ctcggccgag gcttacggcg aggccatagc
2699041 ccgcgccaac acggagcccg acgcgcaccc gacgctgcgg ctgaccacca acctgcggat
2699101 cgggctggag ggccgggaag cacgcgcacg cacccggatg aaggagggtg acgacgtgtt
2699161 cgtcgcgctg agctggacca aacacccgcc gccgcagacc tacgacgagg ccgccgacaa
2699221 gatgtggcaa accaccgagt gctggcggca gtggatcaac atcggcaact tccccgacca
2699281 cccatggcgg gcgtacctgc agcgcagcgc gctaaccctg aaggggttga cctactcccc
2699341 caccggggcg ctgctcgcgg cgagcaccac gtcgctgccg gaaaccccgc gaggcgaacg
2699401 caactgggac taccgctatg cctggattcg cgactcgacc ttcgcgctgt gggggctcta
2699461 caccctggga ttggaccggg aagccgacga cttctttgcg ttcatcgccg acgtgtccgg
2699521 cgccaacaac aacgaacgcc atccgctgca ggtgatgtac ggggtgggcg gtgaacgcag
2699581 cctggtcgaa gcggagctgc accatttgtc cggctacgat catgcccgcc cggtgcgcat
2699641 cggcaacggc gcctacaacc agcgccaaca cgacatctgg ggttcgatcc tggactcgtt
2699701 ttacctgcac gcaaagtccc gcgagcaagt cccggagaac ctatggccgg tgctgaagcg
2699761 gcaggtggaa gaggccatca agcattggcg tgagcccgac cggggaatct gggaggtgcg
2699821 cggcgagccg caacacttca cgtcgtcgaa ggtgatgtgc tgggtcgcct tggaccgggg
2699881 ggccaaactg gccgagcgtc agggcgagaa aagctacgcc cagcagtggc gggccatcgc
2699941 cgacgagatc aaggccgaca ttctggaaca cggggtggac tcgcgcggcg tgttcaccca
2700001 gcgctacggc gatgaggcgt tggacgcctc actgctgctg gtggtgctga cccgattcct
2700061 gccgccggac gacccgcggg tgcgcaacac cgtgctggcc atcgccgacg agctgaccga
2700121 ggacggcctg gtgttgaggt accgggtgca tgagaccgac gacgggcttt ccggcgagga
2700181 aggcacgttc accatctgct cgttttggct ggtatcggcg ctggtcgaga tcggtgaggt
2700241 gggccgcgcc aagcggctgt gcgagcggct gttgtccttc gccagcccgc tgctgctcta
2700301 cgcggaggag attgagccgc ggagcgggcg tcacctgggc aacttcccgc aggcgttcac
2700361 ccacctggca ctgatcaacg ccgtggtcca cgtgattcgc gccgaggagg aagccgacag
2700421 ctcggggatg tttcagcccg ccaacgcccc catgtaggac ttccgatgcc gagcagacgc
2700481 aaaatcgccc aaattcgggc cgaaatgggc gattttgcgt ctgctcggca agcgtcaact
2700541 caattcgctg atcctgtcca tcatcgcgtg tgcgatatcg acggcgctgg tgctgatgtc
2700601 ggccgacccc tgatccgacg ggtgggtgat gccaaagaag gtgaccgcga cctcgaccac
2700661 gcaattgccc cgtacgccga cggcacgggc ctgagggacg gacgccagta tggagtgcgt
2700721 gccgcgtcgc agcgagaccg ttgccgcgac aactgaatcc gcaacccgga cgtcggtgat
2700781 ggagcgttga ccgaacgcgc tggcgggcac cgtcagcgtt gtgccatcac attccttcca
2700841 ctgcgcagaa aacctcgcga acagatcatc ggcggctgcc gcggaaggca gggcgacgac
2700901 accctcatcg acgtcatcca ccttcaccga ggaaccgtcg tgtcgccacg acacccgggc
2700961 gacgcttttg acctcgacgg accggtaaac gttccgctgc gtcaggtaac cgacgcccac
2701021 gcagtcagcg ggccgagccg atacatcact gtctcccaaa ctgtcgctgc ccccgaacac
2701081 cggcgggaaa ggtggaaggg cctgaaacgg ctggttgagg agcgttgaca gcgcagcgcc
2701141 gtcgagcggt acccgctgga tcagtgaacc catcagcgga cgcggcactg cgttcggcgc
2701201 cagacctgct ttcccggtcg tcgttgtggt gcacccggca gcgaggaaca cggcaaacag
2701261 cggaaccacc cagcgccagc ggtttgtcac ttcttgcctt tgtccccggc ggcatcggtg
2701321 gacaatgccg cgacgaaagc ctcctgtggc acctcgacgc gcccgatggt cttcatccgc
2701381 ttcttgcctt ccttctgctt ctccagcagc ttgcgtttgc gcgtgatgtc gccgccgtag
2701441 cacttggaca acacgtcctt gcggatcgcg cggatgtttt cgcgggcaat gattttcgat
2701501 ccgatggcgg cctgcaccgg cacctcgaac tgctggcgcg ggatcagctc cttgagtttg
2701561 gtggtcatct tgttgccgta ggcatacgcc gtgtccttgt gcacgatcgc gctgaacgca
2701621 tccaccgcct cgccctgcag caggatgtcg accttgacca gcgcggcctc ctgttcgccg
2701681 gcctcctcgt agtcgaggct ggcatagccg cgggtgcgcg atttcagtgc gtcgaagaag
2701741 tcgaagatga tctcgccgag cggcatggtg tagcgcagtt ccacccgctc gggggagaga
2701801 tagtccatgc cgcccaactc gccgcggcgc gactggcaca gctccatgat ggtgccgatg
2701861 aactcgctgg gcgcgatgat ggtggtcttg acgacgggct cgtagaccgt gcggatcttg
2701921 ccctccggcc agtccgacgg attggtcacc cggatttcgg tgccgtcgtc tttgtgcacc
2701981 cgatacacca cattgggtga ggtcgagatc aggtccaggc cgaactcgcg ctcaaggcgc
2702041 tcacgggtga tctccatgtg cagcaggccc aagaaaccgc accggaaccc aaaacccagc
2702101 gccaccgagg tttccggctc ataggtcaag gccgcgtcgt tgagctgcag cttgtccagg
2702161 gcgtcgcgca ggttcgggta gtccgaaccg tcgaccggat acaaccccga gtagaccatc
2702221 ggtttgggct cacggtagcc ggtcaacgct tcggcggcag ccccgcgggc ccgggagagg
2702281 ctggtcacgg tgtcgcccac cttggactgg cggacgtcct tgacgccggt gatcaggtaa
2702341 cccacctcgc cgacaccgag gccctcacac ggtttcggct cgggtgagac gatgccgacc
2702401 tcaagcagct cgtgggtggc gccggtggac atcatcatga tgcgctcacg ggggctgatc
2702461 ttgccgtcga cgacgcggac gtaggtcacc actccgcggt agatgtcgta aacggagtcg
2702521 aaaatcattg cgcgggtagg tgcctcggcg tcgccctgag ggggcggcac ctgtcggacc
2702581 acctcgtcga gcaggtcgga cacgccttcg ccggttttgc cggacacccg caacacctcg
2702641 gccggctcgc agccgatgat gtgtgccatc tcggcggcgt aacggtccgg gtcggccgcg
2702701 ggcaggtcga tcttgttgag caccgggatg atgtgcaggt cgcggtccaa cgccaggtag
2702761 aggttcgcca gcgtctgcgc ctcgatgcct tgcgcggcat cgaccaacag caccgcaccc
2702821 tcgcaagcct ccagcgcacg cgagacttcg taggtgaagt cgacatggcc cggggtgtcg
2702881 atcagatgca gcacgtagtc ggtcttgtcg acccgccagg gtagccgcac attctgggcc
2702941 ttgatggtga tgccgcgttc ccgctcgatg tccatccgat ccaagtactg ggcccgcata
2703001 gagcgttcgt cgaccacgcc ggtgagctgc agcatccggt cggccaacgt tgacttgccg
2703061 tggtcgatgt gggcgatgat gcaaaagttc ctaatctgcg ccggcgcagt gaaggttttg
2703121 tcggcgaaac tgctgatggg aatctcctgg agcgggggtt gacgggtatc cagggtatcc
2703181 gcgtcgggca gctgcgaccc aatcgcgctc ggtcgatcgc gtctatgctg cgagcatggc
2703241 gtccgcacgg aagtcacagt ggaaaacgtt gcagcgcttc gcggagaacc tggtgttcac
2703301 tgaggctcct aagctggtgc gtcacctgca aaacacgcag gaaacgcttc gcacaatccg
2703361 gcaagccgtc aagatcaccg cgaacatcat gaccaccgcc gtgccgtcgc caccggccga
2703421 aattgccgcg ggccggccgg tgaccagcac cagctgtccc accgcagcgc gagcccgcag
2703481 acttgtctac gccccggacc tcgatggccg ggccgatccc ggcgagatcg tgtggacttg
2703541 ggtggcctac gagcaggacc ccacccgcgg caaagaccga cccgtgctcg tcgtgggccg
2703601 agaccgcagc gttctgttgg ggttgctggt gtccagccag gagcgccatg ctgccgaccg
2703661 ggactgggtg ggaatcggtt ctggcgcttg ggactacgag ggccgagaaa gctgggtacg
2703721 gctggaccgg gtgctcgacg tacccgagga gagtatccgc cgcgaaggcg cgattctgga
2703781 acgcgaggtc ttcgacgtgg tagccgcccg gctgcgtgcc gactacgcct ggcgctaaac
2703841 cgggccgggc ggccagcgca atcggctggg caacgagccc cgatcaggcc ccaatcagcc
2703901 ccgcctggcg acgacgcggg ccgcccagcg gcccgctgag gagccgggca gtcagccccg
2703961 cccggcgacg atgcgggccg cccagcggcc cgctgaggag ccgggcaatc agccctgagt
2704021 gatgtaggac tgaagctgct gctgctcggc ctcgagttct cccatgcgcg atttcaccac
2704081 gtcaccgatg ctaacgatgc cgatcagttt cttcccgtcg agcaccggca cgtggcggac
2704141 ccggttttcg gtcatcagca cactgatctt gtcgaccgtg tcggattttg tacaggtggc
2704201 gacggtggtc gacataatct tggcgaccgg gcgagacagc acgctggcac catacgtgtg
2704261 tagctggcgc accacgtcgc gttccgacac gataccgacc acgccttcgg cgccgaccac
2704321 taccatggcg ccgatgttct gctcagcgag gccagcgagc agctccccga ccgtggcgtc
2704381 ggggttgatc gtcaccaccg ccgccccctt gttccgcaag acgtccgcga tgcgcatcaa
2704441 ggcctcccgc cggtggtgag ctggttcaca ccaggctacg gcgaactcgg gcggcgggaa
2704501 agccgatacc ggaatatgcg gcatctagca cccgaacccg caggtgcccg gcggtcggta
2704561 gctgcgtagc ccgggcagga attcggccgc cgacaacgcc catgtcggcc gcatcctcga
2704621 ggctaaaact cgttggccat cagccgaatc ggtcgatcgg ggccgctgga tccatcgagc
2704681 ttgtcaggat agggccatgc ttgagatcac gttgctcgga actgggagcc ccattcccga
2704741 cccggaccgt gccggaccat ccactctggt gcgggccggc gcgcaggcgt tcctggtgga
2704801 ctgcggtcgc ggcgtgctgc aacgcgcggc ggccgtcggt gtgggcgccg caggattgtc
2704861 ggcggtgctg ctcacccatt tacacggcga cgtgcttatc accagttggg tcaccaactt
2704921 cgctgctgat cccgcgccct tgccgatcat cggaccgccg ggcaccgccg aagtggtgga
2704981 ggcgacgttg aaggcattcg gtcacgacat cggctatcgg atcgcccacc acgccgatct
2705041 gacgacacca ccaccgatcg aggtgcacga atacaccgca ggcccagctt gggatcgcga
2705101 cggcgtgaca atccgggtgg cccctaccga tcatcggccg gtcacgccga cgatcggatt
2705161 ccggatcgaa tccgacggtg cttcggtggt gctcgccggt gacaccgttc cttgtgacag
2705221 cctcgaccag ctggccgccg gagcggatgc gttggtacac acggtgatcc gcaaagacat
2705281 cgtcacgcag atcccgcagc aacgggtcaa ggacatctgc gattaccact cgtcggtgca
2705341 ggaagccgcc gcaaccgcga accgcgcagg ggtgggaacc ctggtcatga cgcactatgt
2705401 gccggctatc gggcccggac aagaagaaca gtggcgggcg ctggccgcga ccgagttcag
2705461 cgggcggatc gaggtcggca acgacctaca ccgagtcgag gtgcacccgc ggcgctagca
2705521 cgccagctat gaccaaccag ccccgacacc agggcgatcg ataaggcaag aagtagatcg
2705581 cccgaaccag cgccgggtcc gtgctgaccc tcgggcgcca cacggtcttg cccagcaaac
2705641 cggtcagccc ggacgctccc gcccgccacg gtgccgccgg ccaacgccga tcgtcgaacc
2705701 ccacccggtc actgaaagct gccgcaggcg gttggctgat gcaacaccgc ggtggcaata
2705761 cgtgcagcgc gaccggctca tcgcggatct acggcgcaac cgcggtgatc ggcgtcacgc
2705821 cgcgggtgcg acccccacgg gaccccggtt cccactgctg tttggcggtg aatcgctgac
2705881 accgtggacg gcgcccagcc gcggctgttc gcggtggtgc agccgacccg atttcacgga
2705941 aacacaggct gtcatcagcg agggaaacta ttcgccgtgc aaagcatttc catggcgcca
2706001 caccgatagc cggcttgtgc tgatcgcacg tcccgatatc ttatgcagtc gcggtccgga
2706061 ggcaatgcgg gccaaagccg ccgatttgga cttggctgcg gcggcaaaga cggtcggagt
2706121 gcagcccgcc gccgatcagg tggcggcggc aattgccgca atattgctgt cacacgccca
2706181 gatctaccag gacatcagca cacagatggc ggcattccac gaccagctcg tagagaaccg
2706241 cacggcagat agcacgtcgt acgccagcgc cgaggccaac gcccagcaga gcctgctcaa
2706301 tgcgatggat gcaccgagct ggcaacagcg ccgagaaacc gtcggcgagg tggggctccc
2706361 agcggaccca gcgggatccg gcacggcgac ggcggcagtg gcggcggcga cgacggcgcg
2706421 ggcaggaagc cgttcggccg cccaggcaac cgtggcgcct atcggcgggc tgaaactccg
2706481 ccgcgaatct gcgctaagcc agccgggtga tctccaccac cacgtcgagg tcggtgacgc
2706541 cctccccaga gtagatccct ttcagcgggg aaacgtcggt gtagtcgcgg cctacaccca
2706601 cactgatgta ttgctcggtg atctcattgt cattggtggg gtcgtagtgc caccatccac
2706661 cggtccaggc ctgaacccag gcatggctgc gcccgtctac cgtctttccc accacggcat
2706721 cacgcttagg gtgtagatac ccagacacgt accgacaggg aattcccatg ctgcgcaaca
2706781 ccatcagcga caagtgcacg aagtcctggc agacgccctt gccttgttcc agcgcatcga
2706841 gcccggacga gtgcacactg gtggtgcccg gaatgtagtc cagctcgctg cgcgcccacc
2706901 gggcggcggc gactacggcc tcgctgggct catggcattt cctgatccgc ctgccgacgg
2706961 catcaacgcg ggcgcttgcc ggggtgtgcg gggttgggcg gagcacttcg tcgaacctgt
2707021 cgatcacggc cgtcgattgc aggtcggccc aggttgcctt ggcggccaac ggctccgggc
2707081 gctcggtctc caccaccgac gaggacgtca ccgtcagttc ggtgtgcggc gcatgcaagt
2707141 caaacgccgt cacggcagta ccccaataat cgatatagcg gtaggagcgg gtggccggga
2707201 tggtttcgac tcggttgagg acgaggttct gccgcgaact cgaccgaggg gtcagccggg
2707261 cttcgttgta tgaggccgtc accggcgact ggtagacata tccggtggtg tgcaccaccc
2707321 gggttcgcca catcaggatt cctcttggct tccgacgagt tggccacgct ggcctgcatc
2707381 cgaccacgca acccagggag ctgcgtgaaa gtactgcagc gccaatgcat ctccgacatc
2707441 acgacaggtc gtctgcaagc ccgccaggcg gctctccaag gtctcgagca ggacgccggg
2707501 ttgcacgaat tccagctcgc tgcgtgcttg ccctaacaac cgctgtgctt cggtggtcgc
2707561 cccgatccgg ctgtgcggat tgtgcatcaa ctcggcgaga ttgtgttcgg ccagcttcaa
2707621 cgagtgaaag accgagcgcg ggaaaagccg gtcgagcatc atgaactcca ccacccggcc
2707681 cgcgtccagc acaccgcggt aggtgcgcag gtacgtgtcg tgcgcacccg ccgagcgcag
2707741 cagcgtcacc caggccggcg acgatgcgct atcccccacc cgtgacagca acagccgcac
2707801 cgtcatgtcg acccgctcaa tcgcgcgccc aagcaacatg aagcgatatc cgtcgtcacg
2707861 caaaagcgtc gaatcggcca ggccggcaaa catcgccgca cggccctcga tgaacgacag
2707921 aaactcgtgc ggcccaaggc gtttggcagc gcgttcgcgt tcaggcaggg cgttataggt
2707981 ggtgttgaga cactcccacg tctcgctgga ggtgacttcc cgcgccgatt ttgcgttttc
2708041 ccgtgccgcc gagatcgcgt cgacaatgga agaaccaccc tggctattgg tgctgaaagc
2708101 caccaggtcc gtcaaggacc agacatccag ctcgtggtcg ggcggctcga tgcccagcac
2708161 ccgcagcagc agccgggagg cctggtcggg atcgacactg gaatcctcga gcaattgatg
2708221 caccgcgacg tcgagaatgc gcgcggtgtc gtcggcgcgc tcgacgtagc gaccgatcca
2708281 atacagtgct tcggcgttgc gggcgagcat cagtggaacg cctgctgttg ttgttgctgc
2708341 tgctgttgcg gttgttggtc gtgcggttca tacccggacg cgtccaccgt tgggtcgcac
2708401 agcggctgcg gcagcgaacg cacaatctgt gcagcgccca actcgcgggc ggccgccgaa
2708461 gcgcgcgggg ccagcaccca ggtgtccttg gagccgccgc cttggctgga gttgaccacc
2708521 cgggaaccct caaccaacgc cactcgggtc agcccgcccg gcagcaccca tacctcgtta
2708581 ccgtcgttga ccgcgaacgg ccgcaagtcc acgtagcggg gcgccagcgt gccttcgatc
2708641 cgggtcggca cggtcgacag ttccatcatc ggctgcgcga tccagctgcg gggatcgtcg
2708701 cggatctttt ggctaacggc cgccaattcg gcctgagagg cttccgggcc gaacacgatg
2708761 ccgtaaccac cggatccctc gaccggcttg aggaccaatt cgcggatccg gtccaacacc
2708821 tcttcgcgtt cgtcatccag ccagcatcgg agggtttcca cgttcgccag cagcggcttt
2708881 tcgtggaggt agtactcgat catggtcggc acgtacgtgt agacgagttt gtcgtcaccg
2708941 actccgttgc cgatcgcact ggacagcacg acgttgccgg cccgggcagc gttgaccaat
2709001 ccggccaccc cgagcaccga atcggcacgg aactgcagcg gatccaggaa ggcgtcatca
2709061 atgcgccgat agatgacgtc gacctggcgc tccccctcgg tggtgcgcat gtatacctgg
2709121 ttgtctcgac agaacaggtc gcggccctcg accaattcga cacccatctg ccgggccagc
2709181 aatgaatgct cgaaatacgc cgagttgtag accccagggg tcagaaccac gaccgtgggg
2709241 tcggcctcgt tggtggccgc cgagttgcgc agcgcgcgca gcaggtgcga agcgtagtca
2709301 tcgaccgccc gcacccgatg ggtggcgaac aggttcggaa agacccgcgc catggtgcgc
2709361 cggttctcca tcacatacga cacccccgac ggcgagcgca ggttgtcctc gagaacccga
2709421 aagtcgccgc ggtggtcgcg gatcaggtcg atgccggcga cgtggattcg cacaccgttg
2709481 ggtggcacga tcccgactgc ctgacggtga aagtgctcac aggaggtcac caaccggcgc
2709541 gggatgacac cgtcgcgcag aatctcctga tcaccataga tgtcgtcgag gtagcactcg
2709601 agggccttga cccgctgggt gatgccacgt tccagtcggg tccactcggg ggccgaaatg
2709661 acccgtggca ccaggtcgag cgggaacggc cgctcctggc ccgacagcga aaacgtgatg
2709721 ccctggtcga tgaacgcacg ccccagcgca tcagcgcggg ccttgagttc ggacgcgtcc
2709781 gacggcgcca gctcagcgta gatacctttg taggggccgc ggacaatgcc ctgggcatcg
2709841 aacatttcgt cgaaggccat cgcatagacg tccgacgtgt tgtagccgcc gaagatgcgt
2709901 tcgccgcgtg tgggcgaccg ccgccgggtc tcgttgagtt ggtttggcag actcacgcgt
2709961 ctcatgctgc ctcaaattcg acattccggc agaccacaga ttccgctttt gggcgaaaac
2710021 gtaaccgact gataacctgg gcagccgaat cacaccgaca aagggaactt gcacgtggcc
2710081 aacatcaagt cgcagcagaa gcgcaaccgc accaacgagc gcgcccggct gcgcaacaag
2710141 gcggtgaagt cctcgcttcg taccgctgtc cgtgccttcc gcgaagctgc ccatgcaggc
2710201 gacaaggcaa aggccgcgga actgctggcg tcgaccaacc gcaagctgga caaggcggcc
2710261 agcaagggcg tgatccacaa aaaccaggcc gccaacaaga agtcggcact ggcccaggcg
2710321 ctcaacaagc tctgacagcc acctgccgac tcatcggccg cggtcggcca ccaactcggc
2710381 gacctgccgg accgcggatt ccagcgcgta gtccgcatcc gcgacggcgc ccttgacgtt
2710441 agcattgagt tcggccacca acctcatcgc ggtcgccacc gtgtcacgcg accaccgccg
2710501 agcctgcttc tgggctttct gcacccgcca gggcggcatc cccagttgtg cggccaggcg
2710561 gtacgggtcg ccggactgcg gcccgacccg gccgatggtg tgcacggctt cggcgagcgc
2710621 atcggccaac accactagcg gctcaccgcg catcatcgcc caccgcaacg cttcggcagc
2710681 tcccgccacg tcgccggcta ccgccttgtc ggcgatgtcg aagcccctca cctcggcttt
2710741 gccgctgtga tagcgccgta cagcggcggc gtcgacggct cctccggtat cggcgaccag
2710801 ctgtgaacag gccgaggcga gttcgcgcac gtcggagccg acggcgtcca gcagggcggt
2710861 cacggtctcg tcgtcgacct tgacccgcag cgacgcgaac tcgctacgga tgaagtcggc
2710921 gcgctcactg accttggtga tccgcgcgca cggatgaacc tgcgcaccca tcgaccgcag
2710981 ctggttggcc agcgatttgg cgcgcccgcc acccgagtgg accactacca gcacggtgcc
2711041 ggccggaaga tcggcggcgg ccgactcgat taccgcggca gcgtccttgc ccgcctccgc
2711101 agcggccccc agcacaacga tccgctcctc ggcgaacagt gacgggctca gcagttcggc
2711161 gagctcatag gcaccgacgt cacccgcgcg cattcggctc accgggacgt cggctgtacc
2711221 tgcccgctgc cgagccgagc gcaacacgtc ggccaccgcc ctttcgacca gcagttcttc
2711281 gtctcccagg accaggtgca acggcttagc ctcgctcacc ccacgatggt gtcacgaagg
2711341 gccgaccagc ccggacagcg accaggcaag cagacatatg acggccaccg ccatcgtttt
2711401 gcacatggcc gcgcgaaacc agcgccagcg ccactgcgca accgtgaaca cggtggcgcc
2711461 accgaccagc agtacgccgg gcagacctgc ggccaccgga acggtcgccg cgggcacacc
2711521 cgacgcccaa tgcgccacgc gcaacaccca ccacacttcg ggcccggtga accggatcag
2711581 cacctgcgcg ccggccggcc acggcacgac cagcacggcc gcaacgctgc ccagcacggt
2711641 gatcggcgcg atcacggccg ccaccgccag attggccacc acggccacca gactgacccg
2711701 gccggagatg gcggccacca gtggcgccgt caccagctgc gcggccgccg cgactgcgag
2711761 ggcatcggcc agcaccttcg gacatccgcg gtcgaccaag cggcgtgacc aaaccggcgc
2711821 gatgacgacc agtgcacccg tggccgccac ggacagcgcg aagccgatgt ccacagcaag
2711881 atggggagcg gcagccagca aaaccagcac gctacccgac aaagctggaa tcgcctgccg
2711941 ccggcgcgca gacagcatcc ccacgagggc aatggcgccc atcacagctg cccgcaacac
2712001 gctggccgtc ggctgcacca ggatgacgaa tgccaccaac gcgacggccg cgcacaccac
2712061 ggccgcacgc ggtccgatca accgtgccga aaccagcgcc gccgcacaca cgatcgtgac
2712121 attggccccc gagaccgccg tcaagtgcgt caggcccgcc gcacggaact cgcggctggt
2712181 taaggcggtg accgtcgagg tatcgccgag aaccagggcc ggcaacatcg tggcctggtc
2712241 agcgggcagc acctcacgaa ccgcggccgc gaatcgatgg cggacgatgt gagcggcgcg
2712301 gtgtaccggg ccggcacggc ccacggtcgg ccgaccggtc gcattgaaca ccgcgaccgt
2712361 caggtcgtga cgcgccgggc gactgatacg cgcgcggaac tggacgggct gtccgaccat
2712421 cagctcgccg aagtccagcg ctcgcgcgaa aaccactacc cggccggatg tctcgtcatc
2712481 ccgcagccgt tgaaccgtcg cccggaacat caaccggccc cgccccagcg acactgggct
2712541 ctcgctgggg gtgaccgtga ccagcgcgga ggtgccaaat gccacggtga ttgggtggcg
2712601 atcgaccgcc tcggagcgca acgcgaccgc aagcccgtac cccgcgccca ccataccgac
2712661 cgcgaccagg ccggcgctga tcgaacccag tcgcggagcg tgccacgacc ggcgcgccac
2712721 acaccaccac agtgcgccgc cgccgagggc caccacgacg cagcacaagg cacacacgtt
2712781 gccgatcggc cacacgatcc cggccgccgt cacaatccag ctgaccagcg ccgccgggac
2712841 caggcgtacg tccaaacggg acgcgccgaa gcccatatgg cgcaccggta tcagacacgg
2712901 accagattgc gccgcttgtc cagccgcgcc ggaccgatgc cgtcgacgtc ggcaagctgg
2712961 tcgacgctgg tgaacctacc attgcgctgc cgccacgcca caatcgctgc ggcggtgacc
2713021 ggcccgatgc cgggcagggc gtccagctgc tccacggtcg cagtgttgag gtcgagcacc
2713081 tcagctgtct taggagctgt cttagggcct gtcgtggctg tgcccgaggt acccgccggt
2713141 cccggcgtcc ccgcaccgac cgagctgccc agcaccctcg gctgtcccga gggcggagct
2713201 agcccgacca cgatctgctc accgtcacca agctgccgag ccatgttcag tccgacggtg
2713261 tccgcgccgt ctaccgctcc gccggcggcc tgtagcgcat cggcgatccg cgcgcccggc
2713321 gccagggtga cgagtcctgg ggtgtgcacc aggccaacca cgctgaccac caccggcagg
2713381 ccggaacggt ccggcgagcc cgggcttgcc gacgacctag ggttcgtcgg cgaaaccggc
2713441 tctaccggag gaagtttggc tgacattacc ggctcagtcc ggtcgcggat caaggtgaat
2713501 accgtcacca gcaccgcgag ggcggcgatc accgccaatg cgacggcgcc ggcacggccc
2713561 ggatctgcgc gtatcctgtc cgcccaacct tgcccacggg aagtgtcggg aagccagcgc
2713621 ggcagcagcg agttcggatc gtcgcgtggc tcgtcgtggt ctggaccgtc gtccgttgga
2713681 tcgtgtggct ccgggtctaa gtgtgcagat gcggcgtgcg agtcgatatc cgggacggca
2713741 ccgagccgcc tttgcagtcg ctcggcgggc agttctgttc gcatgggccg accgcagctg
2713801 cggggaccgc cagaaccggc gcgcacgacg gcgtcgcgct gccctgctgt ggatcaatcc
2713861 gaggctgtgg acaagccgct ttggcgatgg atcaagatgg gacaaaccgc gccaacatcc
2713921 ccgaacaacc agcaccgggc tgcgacgtcc atccggactc ggctcaccgc gatcgagagt
2713981 gtactcggca acgcgatccg cgagtgctga gccgcgcggc cgatccccat ccatggcgtg
2714041 tggcgaccga agccggcgcg cagcacgcgg gtcgctgacc acgccgaaaa gcccgtcagc
2714101 ctagcgccgg cctagcacgg ccttcagaac tcgaacgcgg tctggacggg aacatcactg
2714161 gcaaacgccg cgtcgagtcg acgaagcagc tgggaatctt tggtgcgcaa ccggttagcg
2714221 gcggctaacg tcgaagcgcg gtgcgctcca aggtaaaggc tgcccagtac gtcccgatcc
2714281 atttcgatct cggctgccgc atcggtcggg gtacaccgcg cacggccgtc accgatcttg
2714341 agcgcgaacc ggccgccatc ggatacctcg aggaccgtgg aaaactcgcc aacttcgtga
2714401 gcgtaaccac gcgcctcgag tgcggccggt acgttcatga tgcgcaacca caggccgtcc
2714461 tggcgccagg tagtgcgggc cagtcgggta tcggtgagca ggtggggtaa cgggtcctgt
2714521 ggatgggtga tgatgctgat tcgctccatg gagtcgaggc caatcagggc ccgccacaac
2714581 gcacaatgcg catctgcggt taccgccctg agttcgctga cgcgcgctag cttgagatcg
2714641 gtgcgatcca cccggtacag cgcgtacccg tcgggatgca gtaacgcgaa cgattcacgg
2714701 tctccaccgg gcgcggcttt gcattctgcc agcagctcgt cccagagcac ctgcgggcgt
2714761 agcagcccgc ccggcacctg ctggcgccat cgctcgtaga tcgcctcaaa ctcgccgcga
2714821 tgctcggtgg gtctgaccaa ccggacgctg ctgccaccta ggccgccgcc cggtgcgtcg
2714881 gcgtgaaagc gcgcgaagcg tcggtcgacc gtcagctcat gcaaggtggt agcgggcccg
2714941 tagccgaacc ggccgtagat gccgccctcg ctagcatgca gtgccgcgac cggatagccg
2715001 gaatcggcta tgcggcggtg cagttcggcg cacatcgcgc gcagcaagcc gcgccggcga
2715061 tgcgtcggcg ccaccgcgac gaaactgaga ccggcggtcg ggagcaccac ttcaccaggc
2715121 accgtcaacc gcagatccat gtacagcgcc atcccgacca cctcagaacc cgggccggca
2715181 ccatcgcgga ccaccaccgc tccgtcggtg ggcaccaggg tccgccaggc ggtcgctgat
2715241 tcagggccga tgaaatcggt gaaactggcc gcggccagta ggaacatccc cggccagtcg
2715301 tcctcggtcg ggctacacag ggtcacagtc acagaatccg actgtggcat atgccgcggc
2715361 cacgtgcacg tgaatattac gacgacagtg tctggcaaag gatcacgcga tgcgggtagc
2715421 cccgccagcg tgacgccact gcgagaatca gcgacgaatt tcgccgtgac gttacgctgg
2715481 cggcgacgct cccacgtcga cgcatacccc gacggctccg gcaccgacgt gcagagcaag
2715541 taccggtccc atggcggtca ccatggccgg ctcacacgcc ggcagccgct ccgccagcgc
2715601 cgccgccacg tcgttcgcag ctgccgggtc ggcgacgtga tgcaccgcga gagcggcggg
2715661 gcggtcgccg acaagctggc aaacccggtc gatcatcacc gccgtcgcgt tgctcacagt
2715721 gcgaacccgt tggaccagaa caagttttcc gtcgtcgact gacagcagcg gcttgagcgc
2715781 cagcgcggtg cccaaccatg ccttggcccc actgatgcgc ccgctgcggc gcagattgtc
2715841 caaccgcgct acagcgacga acgcgtgaat ccggcttacc gccgcagccg ctgcgcgcgc
2715901 gaccgtatcc agctcatcgc ctgcggcggc tgcccgcccg gccgccagtg ccgcgaaacc
2715961 gacgcccatc gcggccgacc tcgagtcgat caccctaacg gcgggaccta gttccgccgc
2716021 ggtcagctcg gcggctcgaa aggtacccga cagcgccgac gaaatgtgca ccgccactac
2716081 cccgtcgccg ccactgtccg ccaacgcccg ttggtaggcg gcggacagct caaccggggt
2716141 cgccccagcg gtggtggcgt ggcgcttgtg gatgtcatcg gggatttcgt ccacaccgtc
2716201 gcgcaggtcg aggccgtcaa gcaagatatg cagcgggacc tggcggatcg accactgttc
2716261 gcgcaggtcg gccggcagtc gacacgacgt atcggtcacc accacaacgg tcaccggcgc
2716321 cgctctcccc cgcaagcggg aggtgccccc acctcatcgc ttcgctctgc atcgtcgccg
2716381 gcgcggggca tgtctcagcc gcgcgatttc tcgttcggca ccccggcttc ggccagtgcc
2716441 ttgagcatca gttcggcgac cgcctggtgg gcttcaaaat tccagtgaat gccatcacga
2716501 ttaccatatc cactcaatat ctgttctgcg acagcggctt tgagatcaac tagaggaatg
2716561 tcatggtgct gtgcccattc cgtgatcgcc gccaccgtgc ctgcgcggcc gtgatgggcc
2716621 ttgccgtagg tctcggcgat atgcaccgag ggcagcgatg cgatgatcgg tatgcccgga
2716681 cgattgaaat caattgcacc acgggtcttt tcaaggtact cagcggtcag gtgcggcggc
2716741 aacgccgcac gggccactgg cgacagtcgc ggttgaaccc aggcgtagcc gtcgcggacc
2716801 caccgtcgca gccaagacgg acgtacatag cggatgagct cacgcagcgc cgtcggtaat
2716861 accgacggca gcgaatccat tccgccggtc gcgaagatca ccgctccggc cctgggtaac
2716921 gccgcccaag cgcgcggatc ctgggttgcc gcccaccaga catcccgaca ggtccagccg
2716981 atgcggccaa tcagctctaa atcccaatct agttgggaag caacaatatt gggccagata
2717041 cgggggtcat cggcaggcag gccgccggtg ggcccgtagt aggccagcga gtcagcgaag
2717101 accaacaatg cgggcctgcg cccgcgccta gaggacatcg ctggagacct gcgccgaagc
2717161 attccacaca tcaaggcgcc accggatgct ctcgaagtcg gagcccgggg cccaatggcc
2717221 actcagctga gtccaactgg cattgcccat gccgcccaaa gccggccagt tggccaccgg
2717281 caacttcagc agcgccgccg acaacgcggc gatcagaccc ccatgggcta ccagcaccac
2717341 cgggcgatcc ggctcgtcag cgccacccca ttccggttcg ctggcaacca actcggcaac
2717401 caacggccga cttcgggcag ccacgtcaac cctgctttcc ccgccgtgcg gcgcccaggt
2717461 cgcatcctcg cgccaggcca accgggcgcc cggggcatca gcgtcgatct gagcgtgggt
2717521 taagccctgc caatcgccaa ggtgagtttc ccgcaatcgg gtgtcgaccc ggaccacaag
2717581 gccggtgcgc tcgcccagct tgaccgccgt gtcatatgcg cggcgcaggt ccgacgatac
2717641 gatcagtagc ggctgccgct tgcccagcac ctcggcggcc gcgaccgctt gggtgcggcc
2717701 aagttcgctc aactcagtgt ccagctggcc ctgcatccgg ctaccgacgt tgtagtccgt
2717761 ttgtccatgc cgcagcatca ccagtcgccg cgctctcatt gcgcacccgc tgagttcgcc
2717821 gataaatcaa ccggcaccac cgggcagtca ccccacaacc ggtccagggc gtagaaattg
2717881 cggtcgtcct gatgctggat gtgcaccacg atgtcccggt aatccaacag cgtccagcga
2717941 ccctcgcggg caccctcacg gcgggccggc cggtaacccg cctgtcgcat tttctcctcg
2718001 acctcatcga cgatggcgtt gacctgccgc tcgttggagc ccgaagcaat gacgaagcag
2718061 tcggtgatga ccagctgccc ggagacatcg atgaccacga cgtcatcggc gagcttggcg
2718121 gcggccgcgc cggcggccac cctcgccatg tcgatggctt cccggttggc ggtcataggc
2718181 cattcccagc ggccaggctg gtcgttgaac gcgcgcccgc gtcgcaggcg ccacagtaga
2718241 gccggcactt ggagacatac tgcacgacgc cgtcgggcat caggtaccac agcggccggg
2718301 actgctcggc gcgctgacgg cagtcggtcg acgaaatggc cagcgccggg atctcgacca
2718361 gagtcaacgc atccttggcc agctgaccca gcaggctagt gatgtgttcg ttgcgcaact
2718421 cgtagccggg ccggctgacc cccacgaacc gcgccaattc gaacagctcc tcccagccct
2718481 gccaggacat tatggaagct agcgcatcgg cgccggtggt gaagtacagc tcagagtccg
2718541 ggtgcaaagc atgcagatcg gccagcgtgt ccttggtgta ggtgggtccg ccgcggtcga
2718601 tgtcgacccg gctcacagag aatcggggat tggaggcggt ggcgatcacc gtcattaggt
2718661 agcggtgctc ggcggcggag acctgtcgac ccttttgcca gggttgcccg ctgggcacga
2718721 ataccacttc gtcgagatcg aacaggtcgg ccacctcgct ggcggcaacc aggtggccgt
2718781 agtggatggg gtcgaacgtc ccacccatga ctcccaatcg acgcccatgc acgattggcc
2718841 agcttactgg attatcttgc cgcagttccg ttcgcggcaa ctgccagcca gcctaagcga
2718901 gcagccattg ataaggcagc acgattggtt attcctaagc ctttgcgtga tcatcttggt
2718961 ctcgttccgg gtgaggtcga ggtcgtcgcc gacggggcgg gactgggtgt cgcgaccctc
2719021 gccggtgact ccctcggcga gcggcatggc ctaccggtga tacccgcggg cagtgcggcg
2719081 cgatgccggc cagcgttagc accgtgctcg tggacacgag cgtcgcggtc gcaccggtgg
2719141 tcgccgatca cgaccaccac gaagatacct ttcaagcgct acgtggccgc accctcggtc
2719201 tggccgggca cgcggctttt gaacgcagga cgctggcgac cgtggcgaag ctgcttgcac
2719261 acacattccc ggcgaccagg ttcctcggcg ctggggcggc gatgtcgctg ctacccgaac
2719321 tcgcaccggc cgaaatcgcc ggcggagccg tctaggatgc gctgatcggt acggctgcca
2719381 acgagcatcg gctccccctg gcaacccgcg accggcaggc gctgaaggtc taccgcgcgc
2719441 tcgcaatgga agccgagctg ctggcctgag cgtcgcggtt gcgcggccaa tcacacccgc
2719501 gccgctgcca ggccaacggc tgcccagctg cccggtccct cacgtttttc acccgatgta
2719561 cccgcaacga tctactcggt cgtgtagaag gggtctgtgg ataatttgcc gatcgaatca
2719621 gccgagtcga cgcggttggc gaaggcggcg atgacccgac ggttttacac ccgctcggtg
2719681 gtgaaaggcg agatcacgct gccggccgtg ccgagcatga tcgacgagta cgtgacaatg
2719741 tgcgccggcc tttttgcggg tgtgggcaga aagttttccg acgaagaact tgctcatctt
2719801 cgcgcggtgc tccagggtca gctggcagag gcgtacgcgg cctcccagcg ttcgaccatc
2719861 gtcatctcat acaacgcccc catgggcccg accttgcact accaagtccg agcccaatgg
2719921 cggacggtgg cgcaggaata cgagaactgg atcgccaccc gtgagccgcc gctcttcggt
2719981 accgaaccag acgcacgtgt gtgggcgctg gccaacgaag cagccgatcc tacgacgcat
2720041 cgggtgctcg aaattggcgc cggaaccggg cgtaacgccc tggcgttggc acggcgcgga
2720101 cacccggtcg acgtggtgga gatgaccccg aagttcgccg acatcattcg ctccgacgcc
2720161 gaacgagatt ccctcgacgt gcgcgtcatc atgcgtgacg tcttctcgac catggacgac
2720221 ttgaggcagg actatcagct gatggtgctc tccgaggtgg tgccggactt ccggacgacg
2720281 cagcagctgc gcaatctgtt cgaactcgct gcccagtgcc ttgctcccgg tgcccgcttg
2720341 gtgttcaacg ccttcctggc gaacggagat tacgcacccg accaagccgc gcgtgagttc
2720401 gggcagcaga tgtataccgg gatgtgcacg cgggccgaga tgtctgctgc agcggccggc
2720461 cttcctctcg aactcgtcgc cgacgactcg gtatacgact acgagaaaac gcacctgcca
2720521 ccgggcgcct ggccgcccac cagttggtac gccgactgga tccgtggcct cgacgtgttc
2720581 accaccaacg ttgagagctg cccgatcgag atgcgctggt tggtgttcca gaggaggcgg
2720641 tgagcagtcg caaaagcccc cgaaaccggt cggatttggg ggctggtacg tgaattaggg
2720701 tgaccacggc aagcgtgacc cgccggcgac tgcagcgaag ccgggtctgt tggtgacagt
2720761 gtgtatgtcg gggtttcagg cggcaggttc gagggtgacc cccaatcctt gggcttcgag
2720821 tttggcgacg aggcgacgtc gttctttgtc gggatccatg cgggtggtga agtagtcggc
2720881 gccgagatcc tggtgaggcc ggccggtggc cagcacgtgc caaatgatga cgatcagctt
2720941 gtgggcgacg gtggtgatcg ccttcttgtt ggcagcggga ctgcggaagc caccgaactt
2721001 gcggacctgg cgacggtagt actcgcgcag gtagccatcg gtgcgcacgg cggcccacgc
2721061 gcactcgacc aggaccggct gcaggtgctg gttgcctgtg cggcgggcac cgtgatggcg
2721121 tttgccggcc gattcgtggt tgcccgggca cagccgcacc cacgaggcca gatgctcagc
2721181 cgaggggaac caggccgccg ggtcggcgcc gatttcagag atgaccgtcg ccgaggcacc
2721241 caccccgatc cccgggatcg atgcaatcag ctcgcgtcgg gcacaaaagg gatgcatcag
2721301 ctgctcgatc tgctcgtcga gagcaccgat catcgcatcg agctgatcca gatgagccag
2721361 gtgcaaccta cacatcaggg catggtgatc atcgaagcgc ccttccagcg cccgctgcag
2721421 atcggggatc ttcgagcgca tactgccgcg cgccagatca gccagcaccg ccgggcggcg
2721481 ttcaccgtcg atgagcgcct ccaccatcgc ccgcaccgac ttgggggtga ccgaggacgc
2721541 cacgctgtcg gccttgatcc ccgcgtcttg aagcacattg cccaggcgct gcagcttcga
2721601 ggtgcgatgc tcgaccagct tgcggcggta gcggatcacg tcgcgggcgg ccttgatgtc
2721661 ggcgggcgga atcaaccaac cccgcagcag accgcattcc agcaggtgca ccaaccactc
2721721 ggcatccaag aggtcggttt tgcggcccgg ccgttcttca cgtgcccggc attgcacacc
2721781 agcagctcac tcgccgtggg ccaacaacgc gtgataagcg ggcgcaccag cgcccatcat
2721841 gttcttttac gactgcccgc ccggcctaca ccggcagtag ctggtcgatc accgtggcca
2721901 gctgcttggc ggatcggcat tcgtgcatcg tgatcacctc ttggtagcgc ggcaccgccg
2721961 agtcaccgct gccccacaga tgcttgggct ccgggttgag ccagtgcgcg tgccggctgg
2722021 cggtcaccat gtcggccagc acgtcggtgg ccgggttgcg gtagttggtg cgcccgtcac
2722081 caagcaccag cagcgagctg cgcggcgaca gcacatttgg gaagccctgc atgaacgaga
2722141 cgaacgcgtt gccgtagtcg gaatggccgt cgcgggcata cacaccagcc tcccgggtga
2722201 tccgctggat cgctatggcc aggtccgatt ccggcccgaa catatgggtc acctcgtcgg
2722261 tggagtcgat gaaggcgaag acgcgaaccc gggagaactg ttggcgcagc gcgtgtacca
2722321 gcagcagcgt gaagtggctg aagcccgcga ccgagcccga cacgtcgcac aacacgacga
2722381 gttccgggcg cgccgggcgg ggtttgtgca acaccaggtc gatcggcacg ccgccggtgg
2722441 acatcgactt gcgcagcgtc ttgcgcagat cgatcgatcc cgcgcgggcg cggcgccgcc
2722501 gggcggccaa ccgggtcgcc agggtgcggg ccaacggggc caccacccgg cgcatctggc
2722561 gcagctgctc acccgaggca cgcagaaact cgacgttctc ggaaagctgt ggaattccgt
2722621 acatctggac gtgctcgcgg ccgagttgct cggctgtgcg ccgcttggtc tcggcgtcga
2722681 ccattctgcg cagctgcgcg atcttttgtg cggcaagcgc tttggcaatc tgttcctggg
2722741 tggctgtggg ctcatcgccg tagggagcaa gcaggcccgc cagtagcttg ccctccagtt
2722801 cgtccagcgc catggccttg agtgcctgat acgacgagaa cgacggaccg cggctggaac
2722861 tgtacttgcc ataggcctca acgatccgcg cgatcatctc caccaaccgc tcgtccttgc
2722921 cggccaggtc ttggttgttg gccagcagat ccagcagcag ctgccgcata gcctcgacat
2722981 catcgggcgg caaacccccg gagcctgccg actcgtcttc cgtggtgatg accgcccgag
2723041 cccccagtgc cgcgggaaac cacaggtcga acatggcgtc ataggtatcg cggtggtcag
2723101 gccggcgcag caccgcacaa gcaatgccct cccgcaacac ctcacgatca cccagcccga
2723161 gggtggccat cacccggccg gcatccaccg tctctgacgg gcccaccgaa atcccgctgc
2723221 cacgcagcgc ttccacaaag cccaccaagt gtccgggcag cccatgcggg gcgagtggcc
2723281 gggcagcacg aatacgacgg gcggccacta gttcaacctg agctctccgg tggcccgttg
2723341 ctggtcggat tggtgcttga gaaccacgcc gagcgtggcg gcaacgaccg catcgtcgat
2723401 ggtgtccagt cccagtgcca agacggtgcg accccagtcg atggtctcgg cgatcgatgg
2723461 caccttctta agctgcatgc cgcgcagcac gccgatgatg cgcactaact cctcggcgaa
2723521 gtgctcgggc agctcgggaa ctcgggataa caggatgcga cgctccagct cgggggtcgg
2723581 gaagtcgatg tgcaagtaca ggcagcgacg cttgagcgcc tcggacagct cacgggtggc
2723641 gttggaggtc agcagcacga acggcgcccg ggtggcggtc agggtgccca gttcggggac
2723701 ggtcaccgcg aagtcggaca gcacctccag cagcaggccc tcgatctcga tgtcggcctt
2723761 gtcggtttca tcgatcagca gcacggtggg ctcggtgcgc cggatagcgg tcagcagcgg
2723821 acgctgcagc aggaactctt cgctgaacac atcggttttg gtggcctccc aatctcccga
2723881 gccggcctgg atacgcagga tctgcttagc gtggttccac tcatacaggg cgcgagcctc
2723941 gtcgacgccc tcgtagcact gcagccggac cagaccggat ccagtggcct gcgccacggc
2724001 gcgcgccagc tcggtcttgc cgaccccggc ggggccttcc accagcagcg gcttgccgag
2724061 ccggtcggcg agaaagaccg ccgtcgcggt ggcagtgtcg ggcaggtagc cggtctcggc
2724121 cagccgccgc gagacgtcgg cgatgtcggc gaacagcggc gtgggccggg cgggcacggt
2724181 cacgatcggg tctcctctag cacgatcggg tctcctctag ccaacggcgt caggccggac
2724241 gggtgtggcc ggctccccat gcgatccact tggtcgacgt caattccggt agtcccatcg
2724301 gtccgcgggc atgcagtttc tgggtggaga tgccgatctc ggcgccgaag ccgaattgct
2724361 cgccgtcggt gaacgccgtt gatgcgttca ccatcaccgc ggccgcatcg atctgttcgg
2724421 taaagcgttg ggccgcatca agattggtgg tcacaatcgc ttctgtgtgc ccggtgccgt
2724481 attcgttgat atgggcgatg gcagcgtcga caccgtcgac caccgccacc gcgatgtcca
2724541 gcgacaggta ttcgcggcgc aggtcggcct cgtccgggtc gagatgtacg gtgacaccgg
2724601 cgtgctgcag ggcggccagc aatcgaggca acgccgtttc ggcgatcgct gcgtcgacca
2724661 gcagcgtctc ggcggcgttg cagacgctgg gccgccgcgt cttggagttc agcaagatac
2724721 gctcggccac gtccaggtcg gccgcttggt gcacgtagac atggcagttc ccgacgccgg
2724781 tctcgatggt gggcacctgg gcatcgcgta cgaccgcctc gatcaggccc gctcccccgc
2724841 gtggaatcac cacatcgacc aggccgcggg cctgaatcag gtgagtgacg gtggcgcggt
2724901 cggcagccga cagcagctgg accgcgtcgg ccggcagctc caggccgacc agcgcggtgc
2724961 gtaacaccgc caccagggcc tcgttggact ttgcggccga cgagctgccg cgcagcaatg
2725021 cagcgttacc cgacttgagt gtcagcccga aggcatccac ggtgacattg gggcggccct
2725081 cgtagatcat gccgaccacg cccaggggga cgcgctgctg gcgcagctgc agcccgttgg
2725141 gcagggtata gccacgcagc acttcaccga ccggatcgcg cagtcccgcg acttgccgca
2725201 acccggcggc gataccgtcg actcgttgcg ggttcaagga caaccggtcc agcatggcgg
2725261 ccggggtgtc cgcctcgcgc gccgcgttca ggtcttcggc gttggccgcc aggatctggt
2725321 cgcggtgagc cagtagctcg tcggcagccg cgtgcagcgc gcggtctttg acagtcgtcg
2725381 gcagcgatgc cagccggcgg gcggccaccc gggcgcggcg tgcggcgtcg tgcacctctt
2725441 gacgcaagtc gagctgcgac ggtgctggca cggtcattgc cccagggtaa cgggcttgcg
2725501 ctggccaggt aagacgaccc gctccggacg ggccgcgcag cgatccggct gggtggttgc
2725561 tatgcgatca ggcgtacttg acggtcgccc ctgatcagct tgccgataat cccggcaaga
2725621 cgctggtagg acttctcgcg gccgccgaaa gagctaaaca ccaaaccgat tcgtcgcgcc
2725681 gggcaggggc gacgaatcgg gcgagttcca gccggcttcg cgtggtctcg acggcggccg
2725741 cggtctgcgg aatcagtgtc acccccagcc cgccggtcac gcactgcacg acggtggcca
2725801 gccacaccgc ccgggtgttg ggcagcatcg agcgtctggt cgcgtaggca gtgcccctca
2725861 tgcagtcaca acaaagtcag ctctgacagc gcggtcagcg gcacccgctg cttgccggaa
2725921 agacatgccc tgggggtgca ccgagaccgg cttccgacca ccgctcgccg caacgtcgac
2725981 tggctcatat cgagaatgct tgcggcactg ctgaaccact gctttgccgc caccgcggcg
2726041 aacgcgcgaa gcccggccac ggccggctag cacctcttgg cggcgatgcc gataaatatg
2726101 gtgtgatata tcacctttgc ctgacagcga cttcacggca cgatggaatg tcgcaaccaa
2726161 atgcattgtc cgctttgatg atgaggagag tcatgccact gctaaccatt ggcgatcaat
2726221 tccccgccta ccagctcacc gctctcatcg gcggtgacct gtccaaggtc gacgccaagc
2726281 agcccggcga ctacttcacc actatcacca gtgacgaaca cccaggcaag tggcgggtgg
2726341 tgttcttttg gccgaaagac ttcacgttcg tgtgccctac cgagatcgcg gcgttcagca
2726401 agctcaatga cgagttcgag gaccgcgacg cccagatcct gggggtttcg attgacagcg
2726461 aattcgcgca tttccagtgg cgtgcacagc acaacgacct caaaacgtta cccttcccga
2726521 tgctctccga catcaagcgc gaactcagcc aagccgcagg tgtcctcaac gccgacggtg
2726581 tggccgaccg cgtgaccttt atcgtcgacc ccaacaacga gatccagttc gtctcggcca
2726641 ccgccggttc ggtgggacgc aacgtcgatg aggtactgcg agtgctcgac gccctccagt
2726701 ccgacgagct gtgcgcatgc aactggcgca agggcgaccc gacgctagac gctggcgaac
2726761 tcctcaaggc ttcggcctaa ccgggatctg gttggccggg aatcaatgag tatagaaaag
2726821 ctcaaggccg cgctccccga gtacgccaaa gacatcaagc tgaacctgag ctcaatcacc
2726881 cgcagcagcg tgctcgacca ggaacaacta tggggaaccc tgctggccag cgccgcagcg
2726941 acacgaaatc cgcaggtatt agctgacatt ggcgctgaag cgaccgacca tctgtcggct
2727001 gcagcccgcc acgcagccct cggagccgcg gccatcatgg gcatgaataa cgtgttctac
2727061 cgtggccgcg gcttccttga aggccggtac gacgacctgc gccccggact gcggatgaac
2727121 atcatcgcca atccgggcat accgaaagcc aacttcgagc tctggtcctt cgcagtgtcc
2727181 gcgatcaacg ggtgctcgca ttgcctcgtc gcccacgagc acacgctgcg tacggtaggt
2727241 gtggaccgag aggcgatctt tgaagcgctg aaagccgcag caatcgtttc aggcgttgca
2727301 caagcgctgg ccacaatcga ggcactaagc ccaagctaag tgtctgtacg cgatgacgcc
2727361 gtgctgggtg acaccggtgc gaccaacacg gtactgtggg cgatcggcgg cggcgccttc
2727421 cacggagtca acttcgacaa cgcatccgac acccgaagcc tgtagtccct catcacctct
2727481 ccgtcctcgt cccagaagtc gtcatattct tggtcgaggt cggcgatctg cgcagtgaat
2727541 tgcccaagcg cgttgttgtc gatcagaatc tgcctctcag cacggttgtt gtagatctgc
2727601 gccaggggca ccatatcgtg atgtgcccat tcataggccc gcacgatctc gtggatctgc
2727661 ctctcgacct cagacagctg cacacagagg tcggtcagcc acctgacaaa cggcttggct
2727721 gcctccatca actgcatcac cactggaccc gcccaggcgt ccatcagaga cagcagcgtt
2727781 cggttgaacg acctctgcac ggccgtcatt tccacatcca acgacctcca cgccctggcg
2727841 gcagccaaca tcgagtcagg accggggccg gcatatatgt tggcggagtt gacctccggt
2727901 gggtacgctt cgaaatgcat ctgtttgttc gttgttccgt cggctcgtga cgactgtagt
2727961 gactcgttaa ctaaaggtct tgatgttgtc ggcctcggcg gtcgcatact tatcggcgcc
2728021 agtggtcaag gcgtgcgcaa actcctcaag aaccaccgcc gccgcagcga tggtctgccg
2728081 atacttcctt gcgtactcga ccaggaacgt cgccgccttc tccgacacca gatccgcagc
2728141 cggaggccgc acagcggttg tcatcggggc cacctgagca tcgctttgga tcgcacgatc
2728201 gcgaatccgt cgtacctccg tggccgccac ggtcaacgcc tcgggatttg tgatcacaaa
2728261 agacatgccg actccactcc gcgattaacg aacccccggc actgcaccgg gctgatcaac
2728321 caccggttgt ttgcgctgcg actgcccacg ttgagaaaac gcaacgactt cactggcata
2728381 attatccaac agacgaaggg atcaattccg ggtaagccgc tgcaaatcaa gccgactcaa
2728441 ggcacacaac gccacccgac gatacccccc atgctgacgt tcaaagcagt agggatgtag
2728501 cttaccatgc cccaatggcc gtcggaggcc agccaccagc gcacatgcct gcacggtgca
2728561 cctaatcggt gccggcttcc agcggccggc agttgacccg cgatgacaga cacgcccagg
2728621 ctcgttgagg ccgatcgcgt tctcacacag cgcattacgg ctcgtgacag atgagggagt
2728681 agagcgggtc ggcaagggaa acccatcatg gcgccgggct ccgccccggg ttgggccagt
2728741 gcgatggctg cgacgtcgtg gaaaagcgcg gtggggtgct cgggcatgac ggatgggcac
2728801 tcatcacatc ctcctgctcc acggcagtgt tcggctcgca ccgtcattgt gctgatggat
2728861 cagaacgtcc gctcgcacgc cggacaccgc gccgcgcacc gaggtagccg acgctagcca
2728921 ccaggaacgg gaccaaataa ttgatcacca tccgtaccca cgtgccgatc gtcgcggcgc
2728981 cctcggcaag ggtggcaccc tgattcaccg cacatagcac ggtacccacg atcagcgccg
2729041 tcggagctgc ggtgcgcagg gtgtggccgc gcagaaacag accgatcgct tggccaaccg
2729101 tgtcccaccg ctcgtcagcg tcgcgcaggc ccacgatgct cgccggccgc cgctggggat
2729161 tggtgcaagt cgcggcgaat tgcctgttgc gccttccttt gccgctcgtc gataacccga
2729221 cccagctcct gcagcagcat cggcttgttc atcacgacct gctcaaggtg ctcccggccg
2729281 atctgcagcg cggtcacctc ttccagcgct accgcaccgg cggggtcggg ttgccgagtc
2729341 agcgcagtca agcccagaaa cgtgcccttt ttgagggtgg caatcgcaac cacggatccg
2729401 tcatcggtcg taaccgtcag ccgcacgctg ccggcgatca cgaaggtgat acccatggga
2729461 accacacccg cgtgctgcac gatctcatca gtgccgtagc gcaccagcct cgcgtaccga
2729521 gccagcgact gctgatcgct agagctcagt cgcagctcgg gccccaccac cgtgcgcagg
2729581 gcggactcca cacgttcggc cgtcgagaac tcgtcgtcgg cctcgtcgag gtgtagccct
2729641 tcccgacgcg cggcgtacca gacccagcgc agaaacgttg cctgcgttgg gccttcgtcg
2729701 gccggtgatg tcagcctgac cgtcgttcga tactcggcgg ctcctcgggc aattgtggcg
2729761 ggcacgaccc cgggcttaac atgcggtagc gcgctggcag ccctgttcag catggcgcat
2729821 accttgtccg ggggatcgga cgtggaaaat gtggtcgtga tcgagcattc gtgcgccccg
2729881 gccggccggc tgagattggt aaacgcggtg gtggccaaca tcgagttggg catgatctgc
2729941 agtccgctgc cggtgtcgat atggacagcc cgccagttca cctcgacgac tcgtccgcgg
2730001 gctgtgggtg tttccaacca atcatcgatc cgaaagggct gttcgaacag catgaacaag
2730061 cccgacacga tctggccgac ggagttctgc agcatcaggc cgatgacgac tgacgtcaca
2730121 cctaacgcgg cgaacagtcc accgacccgc accccccaga tgtaggacag gatcaccgcc
2730181 aaacctatgc cgatcagcgc gaagcgcgcg acatcgacga agatggcggg tagccgcttg
2730241 cgccagctct gttggggcgc accctgaaac agggtggcat tcagtaacga cagcagcagc
2730301 accagcacca gaaatccgaa cgctgtcgtg agcacccgca cggtggggtc ctcggccggg
2730361 acttcagatg ccttgacaag cagcagcaaa accgcgccca ggggtagcag gtagtttcgc
2730421 agcagacttg cctgcctggc cagatggctg ttccgtcgga cgagtatgtt gtgcagttcg
2730481 gtgagaacga ttagcccggc cggcaatccg atcgcaatgc caacggccca gtagaaccat
2730541 gtcgagtcga gcaggttcat gatcgctccg acaatcggta gatcggctct tctaaccctc
2730601 cgacagaaat cgtgcccgca gccgtgaact gccacacgtc tcgcatcgcc tcatacacct
2730661 gcgaggtgac atagatgccg ggctgtggtg aaccgctgtg catttggtag gccagactca
2730721 ctgccgcgcc ccacatgtcg tagacgacac ttgatctgcc gaccagcccg ctaatgacgt
2730781 ccccggtgtt gataccgact cgcaggtgca gatcgttacc ggtttggcaa ttgaaccgat
2730841 cgacgatgcg ccgcatctct agggcgaagt cgacggttcg gggaatattg tccagccgtg
2730901 gcgtggttac cccgcaaccg gcgagatagc cattgtgcag cgtgcgaatg cgttcgacac
2730961 caaggtgttc ggcggccgaa tcgaactggc ggaccagctc gtcgacaatt ttgaccagtt
2731021 cgttacccga caggccgctg gaaatctcgt cgacacccag gatgtcggca aacaggacgg
2731081 tgacatcttg gtgctcctgc gcaatggtct gctccccaag gcggtaccgc tcgacaactg
2731141 gctcgggcat catcgatagc aataaccggt cgttttcctt gcgttgctcg ttgagcagct
2731201 cctctttggt ttgcagattc cgactcatct cgttgaaagc ggctgtaaga tcaccgattt
2731261 cgtcgcgtga ctttaccgga atgttgactt cgtagtcgcc tgcgctgatc ttctgggtgc
2731321 caacctcgag ccgccggatt ggccgcacca tcgcatgggc gatcagcatc gacgccacac
2731381 agatgacgac aatgatgcca actgtaacca gcacaagcgc cctgctgaac gacgcgacgg
2731441 ccgcgaacgc ctcagaatcg ttccgcgttg ccaggatcga ccagtgcaga tcggagtccg
2731501 gcacattcag cggcgcgtag gcctccagtt ccctgctacc cgtgtagtcg gtggaggtga
2731561 cggttccggt ctgtccgcgt tgggcggcgc gcagtccttc ggtcgcaaca ggctgcagca
2731621 gcgtcgtccc accgaactgg atcgctctgt tgaccacatc aagtgacgtg cctgctgcca
2731681 caacctgttt ccggtattcc tccgggtctt gcaggaagag ccgagaatcg gaccgcatca
2731741 gactgtccgg accggcgaga taggtttccg tcccactacc catgccagcc gcttgccatt
2731801 gcctgtcggc ggtcatgatc ttattgatct tgtcgatcgg caacggcagc gccaaaacgc
2731861 cctgagtttt gccgcccgct tcgaccggtg ccaccaacca cgcggtcggc acgccgagtt
2731921 gaggctgata cggcttgaag tcggtaatcc aggtaaagtc gacggcgttg gcgcccaacg
2731981 ctttaaggta ggcgtcacgc agattggatt cgcgatacgg cccggtcaga atgttggtac
2732041 cgaggtcggg gtccttgctc agggtataga cgatattgcc ccgggtgtcc agcaataccg
2732101 cgtcgtcgta atcgaaccgg gtgacgattt cccggaaata gctgttgaat tgcgcgttgg
2732161 cggccgacca tgcactgccg tcgccggcat cgtccagccg catcgcatct tggtccgacg
2732221 tgaatggtgc agtgtagtac gcctgaagat acctttgggc cggagaagtc ggcagcagcg
2732281 cggtgatgtc gagtttatcg ccggtcgtgc gttcgacggg tgtgatgaat tcgttgttgt
2732341 agtagttgac gatcgcctgt tgttgggcgg ggctgatcgt ggcgtcagcc agctggtcaa
2732401 agccggccgt gaaccgcacg acggcatcga caaccgtgag tccacgttcg taaatgacca
2732461 gcgaattcgt caggtcagaa aatagtgtct caactgcccg cttctgcgac tcgcgcaact
2732521 gggtcaaccg ctcgtaggcg gctgctctta gcgaagtgcg accagattga tagacaatgg
2732581 ccgcaatcgc cgcgacggac acgatactcg tcaacagcag cagcaccatg agcttggact
2732641 ggatgctggc ccggaaacgc ggccgacgcc ggagcacatt cttatggcgc ttcttagccg
2732701 gggtggattc actctcggct accgagtcca gtgcctcacc cgacgtcaac cggcttcccc
2732761 tctgctgtcg gtcgcaggct gctctacgac gcgccgatta cgcagcagac taacgtgccc
2732821 agcccacgat catcgcgttt gccgaaaagc caccagcgac caatcgagga atgcgccgcg
2732881 tacgggtcct cgtcatcgtc ctcgtcgcgc acgcgcttct tgaggggtgg tagcgattgg
2732941 ttctgggtgg tccgtaatcg aggtgagcca ggatagctcg gccgtatcgc aatgttcagc
2733001 gagtcgatgg atcaacacat gccccggcac cggcaaccgc tgcggagtgg tcaacgcatc
2733061 aaacgacgac gcactcagac catcgaccga cagcatcgag ccggtccagc atcccgacca
2733121 cccgtcccga tccgcaagca tgttcgaata ctgggacgcg ccaccgacag gacacccact
2733181 gatacccttg ggacaaaagt gacacaagtg atttcagcca acagcaagca tggcaaacgc
2733241 cagtgagact aacgtcggcc ccatggcgcc ccgggtgtgc gtggtaggca gcgtgaacat
2733301 ggacctgacg ttcgtggtgg acgcgcttcc gcgccccggc gagacggtgc ttgcggcgtc
2733361 gttgacccga acgccaggcg ggaagggcgc caaccaggcg gtggccgcag cgcgcgcagg
2733421 cgcgcaggta cagttctccg gtgcattcgg cgacgatcca gccgccgccc agctgcgggc
2733481 ccacctgcgc gccaacgccg ttggactgga caggaccgtc acggtgcccg gaccgagcgg
2733541 gacggcgatt atcgtggtcg atgccagcgc cgagaacacc gtgctggtgg cgccgggtgc
2733601 caatgcacat ctgactccgg taccctcggc cgtcgccaac tgcgatgtac tgttgaccca
2733661 gttggagatt cctgttgcaa ccgcgctggc agccgcgcgg gcagcccagt cggccgatgc
2733721 ggttgtcatg gtcaacgcct ccccagccgg ccaggatcga agctccttgc aggacttggc
2733781 cgctatcgcc gacgtggtga tcgccaacga gcatgaggca aacgactggc cgtcgccacc
2733841 aacacatttc gtgatcaccc tgggtgtgcg cggtgcccgg tacgtcggcg cggacggggt
2733901 gttcgaggta cccgccccaa cggtaacgcc agtggatacc gccggcgccg gcgacgtatt
2733961 tgccggggtc cttgctgcga attggccgcg caacccaggt tcgccggccg agcgactgcg
2734021 cgcattgcgg cgggcctgcg ctgcgggtgc gctggcaact ttggtgtccg gtgtcggcga
2734081 ctgcgcaccg gccgccgccg cgatcgatgc ggccctgcga gccaaccgcc acaacggttc
2734141 atgaccactg ctacgcaccg aaggagaccc gctgatgcga acgaccaccg cggccgactt
2734201 agcgctggca ctcttcgcgg ttttcagtgt ggtcggattc ggctgacgca gttggctgca
2734261 gcaccgacgc accggatcca ccggctttcg cggcgtcagc ggccgggtcg gttcgctgga
2734321 gtggattacc gggacgtgct ttgtcatcgc cctgatcgtg acggtggtcg ctgcggtgct
2734381 gcagcggacc aacgttgtcc aaccgctgaa tactctgcgc atggtctgga ttcaggttgc
2734441 cggcataatc ccggcgacgg ccgggatcgc ggccacggtt tacgcccagc ttgcgatggg
2734501 cgattcgtgg cggatcgggg tggacgagca ggagaacacc actctggtgc gcaccggccc
2734561 gtttaaatgg gtgcgtcacc ccatctacac ggccatgatg gcgtttggcc tcgggctgtt
2734621 gctggtgact ccgaatctcg ttgccctcgc cgggtttatc ctgctcgttg ccacgctcga
2734681 ggtgcatgtc cgccgcgtcg aagaacccta cctgttgcgg acgcacagtg ccgtctaccg
2734741 cggctacacc gccagcgtcg gccggttcgt cccgggtgtg gggttgatcc gctagccctt
2734801 gggcacctca cggtcgatct gatcgagcca gattcgcgct gacatatccg acggggcccg
2734861 ccaatcccca cgcggcgaca acgcgccccc gtgggacacc ttggggccgt tgggcaatgc
2734921 cgaacgcttg aactggctaa acgaataaaa ccgctggacg aaaatctgca gccaatgccg
2734981 gatttcggcc aatgaatagg acgggcgttc gctctttggg aagccgggcg gccagttgcc
2735041 ccgctccgca tcgttccacg catgccaggc caaaaacgca atcttcgacg ggcgaaatcc
2735101 gtagcgcagt acctgaaaaa gcgaaaagtc ctgtagggcg aaaggtccga ccttggcctc
2735161 gctgctctgc agctcctcct cgccggtcgg aatgagttcg ggggtgatct cggtgtcgag
2735221 caccgactgc aatacctcac ccaccttctc accgaactca cccgccgaaa tgacccaccg
2735281 gatcaggtgc tggatcagcg tcttgggcac accggcgttg acgttgtagt gcgacatctg
2735341 gtcgccgaca ccgtatgtcg accaacccag tgccagctcc gacaggtccc cggtgcccag
2735401 tacgattccc ccgcgctggt tggcgatacg gaaaagatag tcggtgcgca acccggcctg
2735461 gacgttctcg aaggtgacgt cgtacacttt ttcgccaacc gaatacggat ggccgattgt
2735521 gtgcagcatc aaccgagcgg tgtcgccgat atcgatttcg gagaaggtaa cccccagcgc
2735581 acgtgccagc ttgatcgcgt tgttcttagt gtgctccccg gtggcgaatc cgggcaacgc
2735641 aaacgccaga atgtcgctgc gcggccggcc ctcgcggtcc atggcatggg tcgcgacgat
2735701 cagcgcgtgc gtcgagtcca atcccccgga cacaccgata acgaccttcg gatagtccag
2735761 cgcccgcaac cgttgctcga gtccagacac ctggatgttg taggcctcgt agcaatcctg
2735821 ttgcaatcgt tgcggatcgg ccggaacgaa cgggaaccgc tcgacctcgc gcagcagtcc
2735881 gatgtcgcct gccggtgggt cgagtgcgaa gtcgatgcgc cggaacgatt ccgttaactc
2735941 ccggtggtga cgccggttgt cgtcgaacgt gcccatccgc agccgctccg accgaagcaa
2736001 ctcggtgtca acgtcggcga cactgcggcg cactcctttg gggaaacgtt cggactccgc
2736061 gagcagtgcg ccattctccc agatcatcgt ctgaccgtcc caggccaggt ccgtcgttga
2736121 ctccccctcc cccgcggcgg catagacata ggcagccaga caccgcgccg acgccgagcg
2736181 cgcaagcagc cggcggtcct cggcacggcc gatggtgatc gggctgccgg acagattcgc
2736241 cagcaccgtc gcgcccgcca gggccgcctc ggcgctgggc ggcatcggca caaacatgtc
2736301 ctcgcagatc tccacatgca acacaaagcc gggtagatct gacgcggcga acaacaggtc
2736361 cgtgccgaag gccacgtcgg cgccaccgat gcggatcgtg ccccgctccc cgtctccggg
2736421 cgccatctgg cgccgctcgt agaactcgcg ataggtgggt agatacgact tgggcaccac
2736481 gccgagcacg gcgccgcggt gaatgacgac cgcggtgttg tagatgcggt gtcgatgccg
2736541 cagcggagcc ccgaccacca gtacaggtaa caggtcggcg gattcggtca ccaggtcgag
2736601 cagcgcgtcc tcgacggcat cgagcagaga gtcctgcagt agtacgtcct cgatggagta
2736661 gcccgacagc gtcagctcag gaaagaccgc caacgctgcg ccatcgtcgt ggcacgcacg
2736721 ggccatgtcc aataccgacg cggcgttggc cgccgggtca ccgatggtgg tgtggtgagt
2736781 gcaggcggca acgcgcacga acccgtgctg gtaggcggag taaaagttca tcgtcctttc
2736841 attgtcgccc agcgacgtca gaacgcccga atcacccgcc gagtatccac gctcgacacc
2736901 gtggaatccc ccgcgctgct ggcagatggc ggcattgacc ggcgtgggga tgctaccgac
2736961 tgggccgctg ccgaccctgg gccctgattg gccgccgagc agtcccatga cgatccgcta
2737021 gttcacctcg gatacccgct cggccgcaat gcgcagctag cggccatgtt gatcgaaatc
2737081 atttggggta caccgcatct cggagcaata tggtagctaa acttgcttag cttgcttcgc
2737141 cgacaccgcg accagatcgt cggcgtgcac caccgggcgg cgcagctcgc cgggtagctc
2737201 agaggtggac cggcccacca tggtggccag ctcggacgcg tcgtaggcaa ccaccccgcg
2737261 ggctaccatg gccgcgtcgg gtgcacgcag ttcgaccaca tcgccgccgc aaaaccggcc
2737321 ggacaccgcg gtgatacccg ccgccagcag tgaccggcgt tgtcgcacca cagcgcgcac
2737381 cgcaccggcg tcgagagtca gtgcgccggt tgcttcggcg gcataacgca cccagaaccg
2737441 ccgggccgac agacgcgcgg gccgggccgc aaacaccgtg cccaccgacg cgtcggcgag
2737501 cgcggtcgcg gcgtcggccg cgggggccag cagtaccggc accccggcgt cggcggccaa
2737561 cagcgccgcc gccaccttgg acgccatgcc gccagtaccc aggtggctac tgcggccggc
2737621 gaccacaccg tccagatccg ccggcccgga cacctccgga atgaacgtcg cgtccgcggt
2737681 tttgcgcggg tcgcagtcgt agaggccgtc gatgtccgac agcagcacca aagcgtcggc
2737741 gccgaccagg tgcgccacca gtgcagacag ccgatcgttg tcaccgaacc ggatctcgtt
2737801 ggtggccacg gtgtcgttct cgttgacaat cgccaccgcg tgcaacgcgc gcagccgatc
2737861 cagcgtgcgt tgggcgttgg tgtgctgcac ccgcatcgaa atgtcgtgcg cggtcagcag
2737921 cacctggccc accgtgcggc cgtagcgggc gaacgccgcg ctccacgagt tcaccagcgc
2737981 gacctgcccg acgctggccg ccgcctgctt ggtcgccaga tctttgggac gacgggacag
2738041 cccgagcggc tcgatgccgg cggcgatggc gcccgaagac acgatgacga cgtcggaacc
2738101 cgccttcatc cgccgctcga ccgcctcggc cagtccggcc agccggccgg catcgaacat
2738161 cccggacggt gtggtaagcg ccgtggtccc gaccttcacg acaaggccgc gcgcggtccg
2738221 gattgcgtcc cgatgcggac ttctcatcag ccatccccgt gttcgcgacg ccgactccga
2738281 gcggcctttc gctcggccgc gcccacccgc ttgttgctgt ccagccgcgg atcggtgccc
2738341 cggccggaca tcgcgaccgg ctcacccgca ggcgtttgcg gctcccaatc gaacgtcatc
2738401 tcgccgatgg tcaccgcgca tcctgaccgc gcacccagcc tcagcaattc ctcctcgaca
2738461 cccaggcgcg ccagccggtc ggcgagatag ccgacggcct cgtcgttgtc gaagttggtc
2738521 tggtcaatcc aacgctcggg ccgggcaccg ctgacgacaa agccaccatg cccgtcgggt
2738581 tcgacggtaa aaccgctgtc gtccaccgga atcggacgaa tcaccggccg ccgtggcacc
2738641 gccaccggcc gcgcagcgtt gtagtccgag atcatctgcg acagcccaaa gatcaacggc
2738701 tgcaggtttt cccgggttgc ggtcgacacg cagaacaccg gccagccgcg ctgggcgatg
2738761 tcgtcacgga cgaactccgc gagctcgcgg gcctccggca catcgatttt gttgaggacc
2738821 accgcacgcg gccgtgcggc gagatcgccc agagccgcgt ccccttgcag cgtgggcgtg
2738881 tagcacgcga gttccgtttc cagcgcgtcg atgtccgaga tggggtcgcg gcccggctcg
2738941 gcggtagcgc aatccaccac atgcaccagt acagcgcagc gctcgatgtg ccgcagaaag
2739001 tccagcccca gaccacggcc ccgggatgcg cccgggatca accccggcac gtcggcgacg
2739061 gtgaacgcgt gctcgccagc cgagaccaca ccgaggttgg gcaccagggt ggtgaacggg
2739121 tagtcggcga tcttcggctt ggccgccgaa atcgccgaca ccagcgagga ttttccggcc
2739181 gacggaaacc cgaccaggcc gacgtcggcg acggtcttga gttccaaggt gaggtctcgg
2739241 gactgtccct tttcgccgag gagtgcgaaa ccgggggcct tacgcacgcg ggaagccagc
2739301 gcggcgttgc ccaaaccgcc acggcctccg gcggcggctt caaagcgggt gcccgcgccg
2739361 accaggtcgg ccagtagccg gccgttctcg tccaatacca cggtgccttc gggaactttc
2739421 acttccaaat ccgcgccggc ggccccgtcg cggttattgc ccatcccgtg cttgcccgaa
2739481 gccgcggtga gatgcgggcg gaaatggaag tcgagcaggg tgtgcacttg cggatcgacg
2739541 acgaagacga tgctgccgcc ccggccgcca tttccgccat cggggccgcc cagcggcttg
2739601 aatttctcgc gatggaccga agcgcagccg ttaccgcccg aacccgctct ggtgtggatg
2739661 acgacccgat cgacaaaccg aggcaccgag ctccccttca tctgcggagt gtgcagctac
2739721 tgcgggtttt gcccctcgtg aatcttcgca gtgggcgcac acgcgcgacg ctcaggcagt
2739781 ggtcgaaccg acgatgctca ccgtcttacg tccgcgtttg atgccgaact cgaccgcccc
2739841 ggccgtcttg gcgaacaagg tgtcatcgcc gccacgcccg acgttgacgc cgggatggaa
2739901 tttggtaccg cgctggcgga ccaggatctc gccggccttg acgacctggc cgccgtaccg
2739961 cttaaccccc agccgctggg cggcggaatc gcgaccgttg cgcgagctgg aagccccctt
2740021 cttgtgtgcc atgtctgtcg cctccgttat gcgatgccgg tgaccttcag gaccgtcagc
2740081 tgctgacggt gtccctgccg tttgtggtag ccagtcttgt tcttgaactt gtggatacgg
2740141 atcttggggc ccttggtgtg cccgagcacc tcaccggtca ccgcgacctt ggccagtgcc
2740201 ttcgcatcgg tggtgacggt ggcgccgtcg acaaccagag ccaccggcag ggacaccttc
2740261 tccccctgct cggattccag cttttcgacc ttgaccacat ctccgacagc gactttgtac
2740321 tgcttgccgc cggtcttgac gattgcgtag gtcgccatca ttgctcctgc ctcttcatac
2740381 ttccgctgca tgcgttgcgc ttcgcgcgcg ggccagcggc gggacgcgtg ctgggtcttg
2740441 ggcgggcacc tacaacggac cccgcatcgt ctccagccgt cagcctggcg acaactggtc
2740501 aagggtacgt gacctgcaac tacggggtca aaccagcggg gcctcagcga gatcgacgcc
2740561 agcacacgaa agtgcgccgg tagcgtcgat ctcgacgcta ccggcgcact ccggggcccg
2740621 ggtggtgacg tcatccgggt tggaccgctg atggctgcgg ctaacatcgt gccgaatcgc
2740681 gtccgatgtc gatctggagg aaccgccgat gaccgccccc ttggatcgtg cgccggtcac
2740741 ggatttgccg gctaacaaca aaggccgaga ccgcacccac tggctgtatc tcgcggtcat
2740801 tttcgcagtg atagccggtg tgatcgtggg gctgacggcg ccgtcgaccg gaaaaagcct
2740861 cacggtgctc gggacggtgt tcgtcaacct gatcaagatg atgatcgcac cggtcatctt
2740921 ctgcacgatc gtgctcggga tcggctcggt gcgcaaagcc gcggccgtgg gcaaggtcgg
2740981 cgggctggct ttggcctact ttctaacgat gtcatcggtg gcgctcggga tcgggttgat
2741041 cgtcggcaac ctactcagtc cgggtaggga tctgcacctt aggcctggtg cggtcggaag
2741101 cggcgcagca ttggccggcc aggctgcgga gtcacacgga atcgctgggt tcatccagca
2741161 gatcattccg aggtcgctcc cctcagccct tactgaaggc aacgtgctgc aggtgttact
2741221 cgtcgcgctg ctggtcggtt tcgcggtcca aggcctgggc cccgcaggcg agtccatcct
2741281 gcgtgccgtc gagaacctgc aaaagctggt gttcaaggtg ctcgtgatgg tactgtggct
2741341 ggctccgatc ggcgcgttcg gtgcgatcgc caatatcgtc gccacgactg gcttcaacgc
2741401 cgtcaccaac ctgctgctgc tgatggccgg cttctacctg acgtgcgtgg tgttcgtttt
2741461 cggcgtcctg ggagtgctac tgcgcatcgt gtcgggtttg tcgatctttc ggctgctgcg
2741521 ctatctagcc cgcgagtact tgctgatctt cgcaacatcg tcgtcggagg tggtgctgcc
2741581 cagactgatc accaagatga aacacttggg cgtgcaatcc agcacggtcg gcgtggtggt
2741641 gccgaccggc tactcgttca atcttgacgg caccgctatc tatctgacca tggcgtcgct
2741701 gttcatcgcc gacgcgatgg gacatcgctt gacatggggc gagcagatcg cgctgctggc
2741761 gttcatgatc atcgcgtcca agggcgctgc cggggtcagc ggtgcgggcc ttgcgacgct
2741821 ggccggcggc ctgcaggctc atcgccccga gctgctggac ggtgtcgggc tgattgtggg
2741881 gatcgaccgg ttcatgtcgg aagcccgttc gctcacgaac ttctccggca acgccgtcgc
2741941 aaccatcctg gttgcctcgt ggacaaagac cattgacctg tccaaagccg acgaggtgtt
2742001 gcgcggtcgt gatcccttcg acgaatcgac catggtcgat ccccacgatg aggagccacc
2742061 cgccgccaca ccccacgggg gcggcgtccc gacgaaccct gcgctgtgcg atttcgagca
2742121 ggtcagtcta ggcggattgg tgggccggcc ggccggcccg caacgcgccg acgtggacgg
2742181 gtaggggcca gctccgtgac accggggacg tcgacttcgc ccggggaacc gtccaagccg
2742241 gctgcatcct cctcgtcgac gtcggcatcg gcggcgtctt cgtcggagtc ttcgtcgtcg
2742301 gaatcggagt cttcaacgtc gagatcctcg tcgaggtcct cgtcgtcgag gtcctcgagg
2742361 tcctcgtcgg cgtcgagctc gtcctcgtct tcgtcggtgt cctcggtgtc ctcgaagtcc
2742421 gcttgggcgg tgtcgtcgag gtcagtgggc ggttgatcgc cggcctgctc ggcgagttcg
2742481 gcagcgggct ccccggattc ctcgtcaccg cgaccagcca gcgaggacaa gcccgctgcc
2742541 atcgccttga acatgggatg ctcaccggga gcgtgcacgg ggaccttggc gaccatgctc
2742601 ctatcactgg actcttcgga ccggctcttt ttcgatcgct tgccccgccg agcaccgggc
2742661 tcagactttc gcccagtcgc cgcggccgaa tcgaccgggt cggcgtgcag caggatcccg
2742721 cggccactgc agttcggaca cgatgtggag aacgcttcga tcagtccggt tcccaaccgc
2742781 ttgcgagtca actgcaccag ccccagcgac gtcacctcgg acacctggtg gcgggtgcga
2742841 tcgcgggcca gcgactcggt caaccggcgc aacaccaagt cgcggttgga ctccagcacc
2742901 atgtcgatga agtcgatgac cacgatgccg ccgatatcgc gcagccgcag ctggcgcacg
2742961 atctcctcgg ccgcttccag attgttcttg gtgaccgtct gctcgaggtt gcccccggct
2743021 ccggtgaatt taccggtgtt gacgtcaatg accgtcatgg cttcggtccg gtcgatcacc
2743081 agcgtcccgc ccgacggcaa ccacaccttg cggtccatcg ctttggccag ctgctcgtca
2743141 atgcggtgca ccgtgaagac gtccggcgcg gactggccat ccggcccgtc agcggactcg
2743201 tacttggtca acttcgaaac caattcggga gcaacagaat tcacgtattc attgatcgtg
2743261 ttccaagcct cgtcgccgga aacgatgagg ccgacgaagt cctcgttgaa caggtcacgg
2743321 ataaccttga ccagcacgtc cggttcttcg tacagcgcca ccgcagcgcc cgcggccttc
2743381 tccttggtct cttgtgcctt ggcctcgatc tgctcccagc gttcccgtag ccgagcgacg
2743441 tctgcgcgaa tgtcgtcctc tttgacgccc tcagacgcgg tacggatgat gaccccagcg
2743501 tcagacggca ccacctcgcg caggatctcc ttgagccgct gacgttcagt gtcgggcagc
2743561 ttgcggctga tcccggtcga cgacgcgccc ggcacataaa ccagaaatcg accggccagc
2743621 gacacctgcg tggtcagccg cgcgccctta tgccctaccg ggtccttgct gacctgcacc
2743681 acgacatagt cgccgggttt gagggcctgc tcgatcttgc gatcggcccc gcccaacccc
2743741 gctgcatccc aattgacttc accggcgtag agcactccat tgcgaccgcg cccgatgtcg
2743801 acgaacgccg cctccatcga cggcagcacg ttctgcacaa ttcccaggta gatgttgccc
2743861 accagggaag ccgaggccgc agacgtcacg aaatgctcca cgacgatacc gtcttcgagc
2743921 accgcaatct gggtgtaccg cgtgcccggc agcggtggct cggtgcggac ccggtcgcgc
2743981 accaccatca cccgctcgac cgcctcacgg cgagccagaa actcggcctc actcaacacc
2744041 ggtgggcggc gccggccggc gtcgcgcccg tcgcggcggc gttgccgctt ggcttccagg
2744101 cgggtcgagc cgtcgatgcc cttgatctca gtggagccag agccgccatc ctgcgagttg
2744161 ccggccttgt cacccgcgcg gggcacgcgt tcgtgtacga cagtgttggg cggatcgtca
2744221 ggcaacgggc cctctaacgc agcgtcgttg tcgtcaccag aagccgactt acgccgtcgc
2744281 cggcggcgcc ggcgacgatt gccggcctcc agcgaaccgt tttcgtcctc gccgttgtca
2744341 ccggcttcgg tatcttcgga atctcgatcg tcgccgtcgt cggtttcggc ggcgtccgcg
2744401 ctggtaaatt gttgggcccg gggctcggat tgctggtcaa ccggatcacc gtcggatcca
2744461 ccctgctccc cgcgtccgcg accgcgaccc cgacggccgc gacgtcgccg ccggttcgcc
2744521 ggccggtcta gctgcccttc gtcgtcagcg tcggaatcgt cggcgacgta gtcggggcca
2744581 tcgtcgacgt cctcgtcgtc cgctaacggc tcgggaatcg gctggggcgc gacgaacagc
2744641 ggcatatagt gcggccgctc cacgtcggca ttccgagtct cctgggtctc tagcatcagc
2744701 cgggactcgg gttcctcgga cgcttcgggc gcatggaccg aggccgccag cacgccggca
2744761 gtctcgagat gagtggccag cagatcgcgc acccggaccg catcgacgcg atccaccgtg
2744821 gaatgtgcgc tgcggacccg tccgtcgagc gcggtgagcg catccagcac ccgcctgctg
2744881 gtggttccca gcgttcgtgc cagcgaatgg actcttaggc ggtccggcag ttcctcatgc
2744941 tggctcggtt ctggtggatc tgaaggtggg gcaccgtcta tcacgtattc tcctcaagcc
2745001 cccgggcgcg tcttgatcga cgcggccacg cgagggcttc gctatctgcc cgggtcactt
2745061 gtctcccgag cttgtgatgg tcttgtcccg agcagctcat gacgaaccca ctcggcaccg
2745121 tgctgaatga cggcccgaca tgccgcgccg catcgaagga tggcgatggt cgcggttgcc
2745181 taagtcttca ttcgggcgtc cgacaccgct tcggcgacgt tcacccgtca tcagtatccc
2745241 acatcactgg gccgagtcac cttcccttga gctggggtgc tgcccaagcc gcccgggatc
2745301 ggcgcacccg gagctaggcg ccgggaaacc agagcgcgat ttcgcgctgc gcggattcgg
2745361 ccgaatcaga cccgtgcacc aggttgaact gcgtctctag agcgaagtcg ccccggattg
2745421 tgccgggcgc cgccgcctgc accgggtcgg tgccgccggc gagttggcga accgccgcga
2745481 tggctcgggt tccctccacg atcgccgcta ccaccggacc cgacgtgatg aactccagca
2745541 acgatccaaa gaatggtttg ccttcatgtt cggcgtagtg ctggctggcc aactccgcgc
2745601 tgacggtcct gagctgcagc gcagcgatgg tgaggccttt gcgctcgatg cggctgatga
2745661 tctcgccgat cagctgcctt tcgatgccat ccggcttgat cagtaccaga gtccgttcgg
2745721 tcacggtgcc caacactaga tgccgcaaga tgtatgccca aaccggtcat tgcgacaccc
2745781 ggtaatcccg acgccgccgc acctcggcac gcaaatacgc gatcaggacc cacaacgcgg
2745841 cgaacagcac gccaatgaaa cccacacccg ggtacacggc gaagccggca accagcaccg
2745901 gttgtgcgcc caggttcacc cagattgccc agggtctgcg ctgcagcccg gtcagcagta
2745961 tcaacagcac ggccagaccg accaaatagc ccagcgaggc cggacgcagc ccaccgccga
2746021 ccgcgtccac taccggtatt gccagcagca ccacgatcgc ctcgaggatc agcgtcgccg
2746081 ccatcaccgc gctgaatccc ttccacgggt cagccggctc acgcgaccgg tcggtcattg
2746141 cggatcacga ccgaacaagg tccgagccgc ccctgcggtg acaaccgagc cggtgatgac
2746201 gatcccggtt ctcgagaatg cgtccccggc cacatccggg tcggcggcgg cgtcgtcgac
2746261 cagtgaggtg gcaacgtcga tagcatcgcg caggttctcg gcggtgcgca cccggtcggg
2746321 tccgaaccgc tcgccggccg ccagcgccag ggcctcgaca tccagcgccc gcggcgaccc
2746381 gttgtgggtc acgacgacgg aatcgaacac cggctccagt gcggccagga tgccgtccac
2746441 gtccttgtcg cccagcacgc tgagcacccc gaccagaaat cggaagtcga actcatgcgc
2746501 cagcgtttgt gccagagcac tcgccccggc cggattgtgc gcggcgtcga tgaacaccgt
2746561 gggtgcgctg cgcatgcgct ccaaccggcc gggactggtg acggcggcaa agccggcccg
2746621 gacggcgtcg ccgtcgagct gacgctgcgc accggcaccg aaaaaggcct cgacggaagc
2746681 gagggcgagc accgcgttgt gcgcctggtg ttcaccgtgc agcggcaagt agatgtcgga
2746741 gtaaaccccg ccgaggccct gcagttgcag tacctgaccg ccgaccgcga tctgtcgccg
2746801 tagcaccgcg aattcggaat cctcccgggc caccgacgcg tcggcgcgca ccgattcggc
2746861 cagcagcacc tccatgacct tcgggacctg acgcccgatg accgcgacgg tgtccggcga
2746921 accgtcgggg gcccgagtga tgatgcccgc cttctccccg gcgatcccgg cgatatcggc
2746981 accgagatag tcgacgtgat caatgctgat cggggtgatg acggcgaccg gtgcgttgat
2747041 cacgttggtg gcgtcccaac gtccgcccat gcccacctcg accactgcca cgtcgacggg
2747101 cgcgtccgca aaggccgcga acgccatcgc ggtgagcacc tcgaacttgc tcatcgccgg
2747161 gccaccctta cccgcagaag cctgcgactg ctggtcgatc agcgccacca acggctcgat
2747221 ctcccggtag gtcgccacat actgcgccgg gctgatcggc ttgccgtcga tcgaaatgcg
2747281 ttccaccggt gactgcaggt gtgggctggt ggttcggccg gtgcgccggt gcagcgcggt
2747341 gaccagcgcg tcgaccatgc gcgccaccga ggtcttgccg ttggtgcccg cgatatggat
2747401 cgacggatag ctgcgttggg gcgagcccag caggtccatc aacgcgctga tccgggtcag
2747461 gctcggatcg atgcgggtct ccggccagcg ttggtcgagt agatgctcaa cctgcagcag
2747521 ggacgcgatc tcgtccggag tgggcacgac gccggtggcc gatcccgagt caggcgggcc
2747581 ggaattcgtc gaattcattg cagcgcagcc aaccgggtgg tgatgcgctc ggtttcctgc
2747641 tgcgccacgc gctggcggtc ccggatcttg gcaatgacgg cgtcgggcgc tttggccaga
2747701 aagtccgcgt tggccaactt ggcggcggtc gacgccagct ccttttgggc gccggccaac
2747761 tccttttcca ggcggcgacg ctcggcggcc acgtcgatgg tgcccgaggt gtcgagctcg
2747821 acgacgacgg tgcggttcat ctcggggccg agccgaacct ccaacgagac cgacggctca
2747881 aaatccgggc ccggctcggt gagccacgcc agcgaggtca cggcggccac ctggttgctc
2747941 agatccgagt cccgcacacc gtgcattcgg gccggaacct tctgccggtc ggccagacct
2748001 tgatcgctgc ggaaccgccg cacttcggtc accaacttct gcatatcgtt aatccgttgc
2748061 gcggcaacaa ggtccacgct aatcccggaa ggctccggcc agtcggcgct gaccagcgat
2748121 tccctgccgg tcagcgccag ccatagcgcc tcggtgagga agggaatcac cgggtgcagc
2748181 aggcgcagca gcgtgtccag cccggcggcc agcacggcgg tggtgtgtgt gagtccctgg
2748241 gcaagctgcg ttttggccag ttcgaggtac cagtcgcaga attcgtccca ggcgaagtga
2748301 tacagggact cacaagcgcg gctgaactcg tatccgtcga aggccgaatc aacttcggcc
2748361 cgaacctctt ccaaccttcc gagaatccag cggtcggcgt cggtcagctc gttcggcgat
2748421 ggcaggggtg ctggcgcggc gccattgagc agtgcgtacc gagtggcgtt gaacagcttg
2748481 gtcccgaaat tgcgcgacgc ccgcacggca tcctcgctca ccgccaagtc accaccggga
2748541 ctggccccgc gggccagcgt gaaccgcagc gcatcggccc cgaacatttc cacccaatcc
2748601 agcgggtcga tgacgttgcc cttggacttg ctcatcttgc ggccagactc gtcgcggatc
2748661 agcccatgca gaaacacgtc ggtgaacggc acctgcgggc cccggcggcc gtcgagggtg
2748721 atggcggcgt cgtcgccgac gaaggtgccg aacatcatca ttctggccac ccaaaagaac
2748781 aagatgtcat agccggtaac cagaacgctt gtcggataga acttttccag ctccgccgtc
2748841 ttgtccggcc aacccagcgt ggaaaacggc cacagcgccg acgaaaacca ggtatccagc
2748901 acgtcaggat cctgttccca gccctgcggg ggtgtttcgt ccgggccgac gcacacctgt
2748961 tcgccgtcgg gtccgtacca gatcgggatc cgatgccccc accagagctg tcgcgagatg
2749021 caccagtcgt gcatgtcgtc gacccaggag aaccagcggg gttccatgct ggccgggtga
2749081 atcacggtgt ccccgttgcg caccgcatcc ccggccgctt tggccagcga ttccacccgg
2749141 acccaccact gcagggatag ccgcggctcg atcggctcgc cgctgcgttc ggagtgtccg
2749201 acgctgtgca ggtagggtcg cttttcttcg accacgcggc cctgggccgc gagcgcttgg
2749261 cgcaccgcga cccgtgcctc gaagcggtcc atgccgtcga atcgcgttcc ggtgtcgacg
2749321 atccggccct tggtgtccag gatcgagggc atcggcagct ggtggcgcac cccgatttcg
2749381 aagtcgttgg ggtcgtgggc gggtgtgact ttgaccgcgc cggtgccgaa ttcagggtcc
2749441 acgtgctcgt cggcgacaat ggccagctcc cggtcgacga atgggtgcgc caggctggtg
2749501 ccgaccaggt gacggtagcg ctcgtcatcg ggatggacgg cgatcgcggt atcgcccagc
2749561 atcgtctcga cccgggtggt ggcgaccacg atgtggggtt gcgagtcgtc aagcgagccg
2749621 tacctaaacg acaccagctc gccttcgacg tcgcggtagt tgacctcgag gtcggagatc
2749681 gcggtctgca gcaccggcga ccagttgacc agccgctcgg cccgatagat cagcccggcg
2749741 tcataaagcc gcttgaagat cgtgcgcacc gcccgcgaca gaccttcgtc catggtgaac
2749801 cggtcgcggc tccagtccac cccgtcaccg agtcggcgca tctggccgcc gatggcaccg
2749861 ccagactctc gcttccaatc ccacaccttg tccacgaaca gctcgcggcc gaggtcttct
2749921 ttagtcttgc cgtcgaccgc cagctgctgc tcgaccacgc tctgggtggc gatcccggca
2749981 tggtcggtgc ccggctgcca gagcacctca tagccctgca tccgcttgcg ccgcgtcaag
2750041 gcgtccatca tggtgtgttc cagcgcgtgg cccatgtgca ggctgccggt cacgttcggc
2750101 ggcggcagca cgatcgaata ggccggcttg gtgctggtcg ggtccgcggt gaagtagcca
2750161 gcgtccagcc acttctgata gatggcgctc tccatcgcgg ccggatccca cgacttgggc
2750221 agcatatcgg cggcagggtg agggctggcg gtcaccgatc aattctagga accgcttcac
2750281 accggcatga aagcgcccga aaccgcccgg attcagctag ccagtcgcgt ggtctgcagc
2750341 gacacaccgg cggccggcaa acgctccagc agggcgtcac ccattgcggc cgcgggggtt
2750401 aacacaccac gcatgtcgga cagcttgtcg cgatccagtg ccagcgccag accacactcc
2750461 cccaacaaca ccgacgtcgc cttgtagccg gggtcaccat cttgggccat gcgcgccagg
2750521 taccgggctc cggtggttgt ggtggtgtag gtctcgatgc ggtagtagcc gcgctcgcga
2750581 gccgccgcac tggggccggt gccgggtttg gggacgacac gctttaccag tccccgcggc
2750641 agcaggcgga tgtagcggct ggccaagccg aacatcgcgt tgccgacacc gccgccgaca
2750701 accgatacca ccggcgccag caccgtggac cctacgctca tggtttcgct gtagcggaac
2750761 cgccggccgt aggcccagtc caggagcgcg ttgctgcggc gcacgatccg ggtgttggtg
2750821 ggcgccatga tgaatcccgc ggtccacaca ccggccagtt ccggcgcgag ccgacggcca
2750881 cgacgcgacg gcaggtcagg ctgtgggccc agttcgggtt cggcgccgcg gtctgggctc
2750941 agcatgtagg ggtcggatag ctggcggcgc gcatcgggat cgttagaagc ggtgctcaac
2751001 acctccagca tcgatgcgat ggtgccgccg gagaacccgc ctttgaagga acgcaccacg
2751061 cagttggtgt cggtcagctc gccggcgccg tcttctcgtg ccgcgtggta tagggcgtac
2751121 acgctcagat cagatgggac ggagtcgaat ccgcaggcgt gcacgatgcg tgcaccggtg
2751181 tcggcggcct gcttgtggta caagtcgatg ctgttgcgca tgaacatcgg ctcgccggtc
2751241 aggtcggcgt agtcggtgcc ggcggcagcg catgcggcca ccagcggcag cccgtagcgg
2751301 gtgtagggcc caacggtggt gaccacgacc tgggcgcggg cggccatggc ttgcagcgtc
2751361 gacggcaacg acgcgtcggc ggtcaggatc ggccaggtct gcgcggattc gcccagggct
2751421 tcgcgaacgg cgagcacccg ttgcgtcgac ctgccggcca gcgcgatccg ggcatctccc
2751481 ccggcccggg ccaggtattc ggcggtcagc ttgccgacga agccggtcgc cccgtacaac
2751541 acgatgtcga attcacgcgg cgtagcggtc acgggtttga cgctactccg gggtgcgcga
2751601 gcagacgcaa aagctcccaa atccgaccgg atttgggagc ttttgcgtct tttcgcggtg
2751661 gtcagccgcg gcggccgcag accggccagg cgcggatacc ctgcgaacgc agcacgttct
2751721 cagccacccg gatctgctcc tcccggctcg cgttggccgc ggaccccgag ccaccgttgg
2751781 cacgccaggt gccggcggtg aaccgcaggc cgccgtagta accgttaccg gtgttgatcg
2751841 accagtttcc accggactcg cactgcgcga tcgcgtccca gttcacgctg taggccacgg
2751901 gcacgggagg cgcttcctcc gcaggcgggg acaggaagtc cggggccagc ggcgggggga
2751961 ggttgggatc aaagcccgcg tcctccggag ccggcggagt atcgacgggt gcagcgtccg
2752021 gggccggcgg caggttcggg tcaaagccca cggcatccgg gccggctgcg gcgtttgggt
2752081 ccaagcccgc gtcgtcggca ttggcgatac cggctggtga cgtggtcacc aacgtcccgg
2752141 caatcgcggc ggcgatgagc gtcgtacggg cgttcttcaa cgttgttcct ttcgcggtgc
2752201 gcgcgcgcca aagccaaccc acgggcatgg gttagctgcc aggtgcattc gagggtgctg
2752261 cgtgggacgt gccgtctcgg tccggcacgg cagcggagcg cttgatctgc ccggcgcggc
2752321 tgctagccgc cgcctgcggg tcggccaacc gattcagccg tccccggctc cgctcgcacg
2752381 cgggtccgta gattcaattg ttgagatttc ttgctgcccg tctgccgggc caaggggacc
2752441 gtacgataac gatttggatt cgtcatctcc ggcaaaccga gatatcagtt caatcacaag
2752501 ccgatcacgg cgcggtggca caattgttgt tgcaggtcag aagtgcggtt ttggctcagc
2752561 tgtatctttg cgaccgcggc gctatcgtga gccgaatcac gcaaatattg tgaccccgga
2752621 cacggatttg tcaccatcgt ggccctggtc cgggatctga tccacacgcc gtggtgacct
2752681 gcgccacaac gacttgccca ccccgacgtc caccacacct cgaatcagct agactgctcc
2752741 caataatccg ccctaatact aagtgccgca ctgtgattca taggtaacct ggggcaccac
2752801 caaatagcag tctgccgtaa cagccggatc ctctaccgtc agcagactca aatgtcctcc
2752861 accccaacgc aatacgtgat caaccgcgca ccagagacgc caactgtagt caaggcagta
2752921 ctagaagcgg cggccatggc caatgttaat aacgtcttca ttgaaaacaa gacgagaata
2752981 tctcgaaagg ccaccagaaa attaatacgg aatagtatta gcgtccgggc tgcatcggtg
2753041 cgtgcaagcc tgcggccgaa ttgacgttgg tcagcggtcg ggaatccgcc atcacgatcc
2753101 gcagtgcatc cgaagcgtcg accagggcgc tcatctttcg ctcgccggca ccgaccaacg
2753161 tgtcgacgcg gtcggccaga tccgtccgat acaccgcggc caggtagtgg ttacggccat
2753221 cccagggcaa caccacttcg gcatcggtct gcaccgcgcg gcgcgcgaga tcctcgatca
2753281 attccactgt cagataaggc atgtcgaccg cacagacaaa cgcgagccgg acaccggcct
2753341 ccgcagccgc acgcaacccg cgaccggtcg ccggcagcgg ccccagcccc ggcagctcat
2753401 cacgcagaac ggggaccggc agcgtgggca acggttgtcc cggagcggcc atcacgaaaa
2753461 ccggcgcgca gcgctggccg agaatgccga ccatatgctc caccagcgtg gtggttcccc
2753521 cggggagggg cagggtggct ttgtcgcgac ccattcggcg ggattcacct cccgcgagaa
2753581 caaccccggc cagcggcact gtgtcgggcg cgagctcagc cacgtcagtc gacggtccaa
2753641 gtgtcgcgcc cgtgcaacag tgactgcagt gcagcggtgc cggacggggc ggcgtttcgg
2753701 gccgcgacta cctgcgagcg ggccgcatca tcgtaggttg gccggctgat gtgccgaaag
2753761 attcccagca cggtgtggtc caggttctga tcggacagcc gggacagcgc gaaggcgtag
2753821 gccgggtcgt cgacctgcgc atcgtgcaca atgatctcgt cgatggccac atcggccgtc
2753881 ttggccactt cgaggccgaa tccggacttg accacgcagt attcgccgtt ggccccgaag
2753941 acgatcggct cgccgtggcg gaccttgatg acccgctcct cggcgccctc cttgcgcagc
2754001 gcatcgaacg agccgtcgtt gaagatcggg cagtcctgca ggatttcgac cagggcagca
2754061 ccgcgatgct gggccgcggc acgcagcact tcggtcagcc cgttacggtc tgagtccagc
2754121 gcgcggccaa cgaacgtcgc ctctgccccc agcgccaacg acaccggatt gaacgggtga
2754181 tccagcgagc ccatcggtgt cgacttggtg accttgccga cctccgatgt cggcgaatac
2754241 tgtcctttgg tcagcccata gatccggttg ttgaacagca gaatcgtcac gttgatgttg
2754301 cggcgcagcg cgtggatcag gtggttaccg ccgatcgaca aggcgtcacc gtcgccggtg
2754361 accacccata ccgacagatc ctcgcgagcc agcgccagac cggtcgctat cgcgggcgcg
2754421 cggccgtgaa tcgaatgaaa gccgtaggtt tccaggtaat aggggaaccg gctggagcat
2754481 ccgataccgc tgatgaacac gatgttctca cgccgcagcc ccagttcggg caggaagttt
2754541 cggatggtgt tgaggatgac gtagtcgccg cagcccgggc accagcgcac ctcctggtca
2754601 ctggtgaaat ccttgccctt ctgcggctga tccgtggtgg gcaccccagc gttcttggtc
2754661 aagctcggag tcaggccgag ctcggtgccc gccaaatcac cggtcacgcc ggtcatgagc
2754721 tgtgcttcat cgccggagcg ggtcatccgt ttgctcccgc tcccgccgtg gccgccgaca
2754781 atctggcgac caacgtcttg tcttgctcaa gctcggccaa tctcccggca agtgcggccc
2754841 ggataaagcg cccaatctcg tcggccagga acgagacacc cttaaccttg gtgaccgatt
2754901 gcacgtcgac caggtactta ccgcgcagca cctgggccag ctggcccaag ttcaactccg
2754961 gagccaccac cttggggtaa cgccgcagca cctcacccaa attggccggg aacgggttga
2755021 gatagcgcag atgggcgtgc gctaccttgg tgcctcggcg acgcgcgcgc cggcacgctt
2755081 caccgattgg gccgtaggag ctgccccacc cgatcaacaa cagctcggcg tccccggtcg
2755141 gatcatcgac ttccagatcg ggaacatgga taccgtcgat cttggcttgg cgcaaccgga
2755201 ccatgaggtc atgattagtc ggctcgtagg agatgtcgcc cgagccattg gcagcttcca
2755261 gcccgccgat gcggtgttcc agaccggggg tgcccggaat ggcgaactgg cgggcaaggg
2755321 tttcccggtc acgggcataa ggctggaagg gctcgccggg tttggcgaag gtgtgcttaa
2755381 tgggcggtag cgcattgaca tccgggattc gccatggctc cgagccgttg gcgatggcgc
2755441 cgtcggacaa caagatcacc ggggtgtggt aggacaccgc gatgcgcacc gcctcaaggg
2755501 cggtttcaaa gcagtcggca ggagagcgcg gcgccagcac cgccaccggt gactcgccat
2755561 tgcggccgta gagcgcctgc agcaagtcgg cctgctcggt cttggtgggt agaccggtcg
2755621 acggcccgcc ccgctgcacg tctatgacca gcaacggcag ttcggtcatc acacccagtc
2755681 ccagcgcttc ggacttcagc gaaattcccg gtcccgatgt gctggtgact cccaacgcac
2755741 caccgtaggc ggcacccagc gcagcgcaga tgccgccgat ctcgtcttcg gcctggaagg
2755801 tgacgacatt gaagttcttg tgcttggaca gttcgtgcag gatgtccgac gccggagtaa
2755861 tcggataact gccgagcacg accggaaggc cggcgagctg accggccacc acgatcccgt
2755921 aggccagcgc ggtattgccc gagatctgcc ggtactcgcc gggcggcaaa gtcgcgggcg
2755981 gtatctcata ggtcgtgccg aaggcctcgg tggtttcgcc gtagttccag ccggccttga
2756041 gggccaacac gttggcctcg gcgatttcgg gcttgcgggc gaacttctcc ctgatgaagg
2756101 cctcgctgtg ctcgagctcg cgcccgtaca tccacgacag cagacccagc gcaaacatat
2756161 ttttggcgcg ctggccatcc ttcttggacg cgccgatcgc ctcgacggca cccagggtca
2756221 gtgtggtcat ggcgacggtg tgcaccacat agtcggacag ctcgccggac tccagcgggt
2756281 ttgtcacgta gcccactttc gtcaggttgc gcttggtgaa ctcgtcagag ttcacgatca
2756341 ccattccgcc aagcggtagg tcgccgatat tggccttcaa cgctgccggg ttcatggcga
2756401 cgagcacgtc gggacggtca ccggcggtca ggatgtcgta atcggctatc tgaatctgaa
2756461 aagacgacac tccgggcaac gtgcccgccg gtgcccggat ctctgcgggg tagttcggct
2756521 gggtcgccag atcgttgccg aaaagcgctg cctccgaggt gaatcggtcg ccggttagct
2756581 gcatgccgtc gccggagtct ccagcgaacc ggatcaccac attttccaag cgttgccgat
2756641 caggcgcggc atgaaatgcc gcgtcatgag actctggccc ggccccgctg ccgttcggat
2756701 ccacgtctcc gccttccatg tgttatcgga caggcactcc gcgctgcagc ttcaggttac
2756761 gcgtcgtcgg agcgacaccc ccgcgccgca cggcttgtgt cactggcggt agcgattatg
2756821 acatttcatt tcgggtgtaa ggcggtctcc gatgccatat atgcggccgg taaccgacca
2756881 aaaggcgaag tcagcgaggg ctggcggtag cgacgacaca gaactgtggt attggtcact
2756941 tccccccgag ggttggccgc gaccgcaccc ggacatccga atccacggtt tccggcatcg
2757001 cgaccaggta caggaggaag ccggccccgg cgagcgcacc cagcgacatg aatgccgcgt
2757061 catagcccgc gacgaccacg atccagccgg caacaagatt agacagcgcg gcaccaatgc
2757121 ccgttgccgt ggttaccgcc ccgaggctga tattgaaatg tcccgttccg tgtgtgacgt
2757181 cctgtacgac aaggggaaac aacgccccga aaatgccggc tccgataccg tcgagcaact
2757241 gcacgcccac cagccagtag gagttatccg acaacgtgta gaggaacccg cgagcggtca
2757301 agacagcgaa ccccaccaaa aagatcggct ttcgccccca cgcgtcggcc ctggtcccga
2757361 ccacatacgc caccggcacc atcacgacct gcgccgcgac gatgcacgac gacatcagcg
2757421 ccgttccttc gtctcgattg tgcaacgcca acagctcgcc gaccagcggc agcatcgccg
2757481 cgttggcgaa gtggaacgcg acaaccgccg ccccgaagat caccagttcg cggttgtgcg
2757541 ccaacacggt gaaccgcgac ggctgcggat gcggctcgcc gggcgcatgg tccataccac
2757601 gcgctaaatc gtggtcgacc gcgtccggcg ggatccgcag tgtcgccagc acgctgatca
2757661 acgccatgcc ggccagcacc cagaacacca ccaccggccc gaagaagtac gccagcgcgc
2757721 cggtcgcccc agccgccgac gcgttaccgg cgtggttgaa cgcttcgtta cgcccaatcc
2757781 gtctggcgaa aaactgagga ccgacagcac ccaacgtgat cgccgccaac gccggagcga
2757841 aaaccgagct ggcgatcccg gtgacggcct gcagcaccga gatggaatac aagcccgcaa
2757901 acagcggcat cgccactgcg gcggcggtga ccagcaccgc gccggcgacg accagcgccc
2757961 gcttggccgt ggtccggtcc accagggcgc caatcggcgt ctgggccacg atggccgcaa
2758021 tgccgccgac cgccatgacg aacccgatcg aggcttgatc ccaatcgtgg atcaacagga
2758081 ggtatatcga cagatagggg cccagaccgt cgcgaacatc agccaacgag aaattcagca
2758141 ggtccagcgc acgcgccacc cgtggcggca ctgccacaac ggtgcccgac atgcagtcgt
2758201 cgcggggcta cgcgctcttg tcgcggcgct ccgaacggga cggcttgcgt ggcacgattg
2758261 tcggcaacac gttgtcctgc acggtctcct tggtgaccac cactttggcg acatcgtcgc
2758321 ggctcgggat gtcgtacatc accggcagca ggacttcttc catgatcgcc cgcaggccgc
2758381 gggcaccggt gccgcgatgg atcgcctggt cggcgatcgc ttccagcgca tcgtcggtga
2758441 actccaactc cacgccatcc atctcgaaca gccggatgta ctgcttgacc aaagcgttct
2758501 tcggctcgga caggatcttg accaacgact ctttgtccag gttggtgacc gaggcgacca
2758561 ccggcaggcg gccgatgaat tccgggatca ggccgaactt gatcagatcc tccggcatca
2758621 cgtcggcaaa gtggtcggtg gtgtcgatct cggccttgga acgaacctcg gcgccaaagc
2758681 cgaggccccg cttgccgacg cgctcgtaaa tgatcttctc cagcccggcg aacgctcccg
2758741 cgacgatgaa cagcacgttg gtggtgtcga tctggatgaa ctcttgatgc gggtgcttac
2758801 ggcccccctg cggcggaacc gacgcctgag tgccctccag gattttcagc aaggcctgct
2758861 gaacgccctc accggagacg tcgcgagtaa tcgacgggtt ctcactcttg cgggcgatct
2758921 tgtcgacctc gtcgatgtag atgatgccgg tctcggcgcg tttgacgtcg tagtcggcgg
2758981 cctgaataag tttgagcaag atgttctcga cgtcctcgcc gacgtaaccg gcctcggtca
2759041 gcgcggtggc gtcggcgatg gcaaacggca cgttaagcat cttggccagc gtctgggcca
2759101 ggtaggtctt gccacaaccg gtgggtccga gcatcaagat gttcgacttg gtcaactcaa
2759161 cgggctcaca tcgggagtca cggcccttct ccccggcctg gatccgcttg tagtggttgt
2759221 acaccgccac ggccagcgtg cgtttggcgg tatcttgccc gatgacgtag ccctcgagga
2759281 actcccggat ctcggccggc ttgggcagct cgtcgagttt cacatcgtcg gcgtcggcga
2759341 gttcctcttc gatgatctcg ttacacaggt cgatgcactc atcgcagatg tacacgccgg
2759401 ggccggcaat gagcttcttg acctgttttt ggctcttccc gcagaacgag cacttcagca
2759461 ggtcaccacc gtctcctatg cgcgccataa tgctgatggc ctacttcctg atcgccgttc
2759521 gtgttgccgt gccccgtgta tgccccgacg ctacccgctt gctccggccc cccgcgaccg
2759581 ttagcaccga atagcgtcct agagatttca gggtgttcac gcctctcgtc tgaatgaaac
2759641 atatagcccg actgcgcccc actcgccgag acgcgcgatc cgtgtctctg gcgtgtcgcg
2759701 gtcgtaaccc caccgaggcc cgcgcgtcgc ggacccggca gcggcccgac cgccagctga
2759761 ccaccctaca gtggcgttgt ggaattggtc agcgattccg tgctgatcag cgatggcggc
2759821 ctggccaccg agcttgaggc gcgcggtcac gacctgtccg acccgttgtg gtcggcgcgg
2759881 ctgctggtgg acgctccgca cgcgatcacc gcggtgcata ccgcgtactt tcgcgctggg
2759941 gcccagattg ccacgactgc cagctaccag gcctcgttcg agggcttcgc ggcgcgcggc
2760001 ataggtcatg acgacgccac cgtgctgctg cgccgcagcg tcgaactcgc ccaggctgcg
2760061 cgcgacgagg tcggcgttgg cggtctatcg gtcgcagcct cggtcgggcc atacggcgcc
2760121 gcgctggctg acggatccga ataccgcgga tactacggcc tgtccgtcgc agccttgatg
2760181 aagtggcatc tgccacggct cgaggtgcta gtcgatgccg gcgctgacat gctcgccctg
2760241 gaaaccatcc ccgatatcga cgaagccgaa gcgctggtca acctggtgcg gcggttggct
2760301 acgccggcct ggctcagcta cacgatcaac gggacgcgga ctcgcgccgg gcaaccgctc
2760361 accgacgcgt ttgcggtggc cgcaggagtt cccgagatcg tcgccgtcgg cgtcaactgc
2760421 tgcgcacccg acgacgtgtt gccggccatc gctttcgccg tcgcccacac aggcaaaccg
2760481 gtgatcgtgt acccgaacag cggtgagggt tgggatggtc ggcgccgcgc ctgggtaggt
2760541 ccgcggcggt tttccggatc ttccgggcag cttgcgcggg aatgggttgc ggcgggcgcg
2760601 cgcatcgtgg gcggatgctg ccgagtacgg ccgatcgata ttgccgaaat cgggcgagcg
2760661 ctgaccaccg cgccgccccg aggctgaaag cgaaaattgc ctctactgcc tcatcgaggc
2760721 gttacctagg gttagttctt gtgaccgcga agcccggcta cgcatgagta agaaccgcat
2760781 tatgggcaac caaccggaga agtcagatgt gactgcggca cccgacaccg tggagggcga
2760841 ttcccacact gcaatgacac cgcgccagcg gctgaccgtg ttggcaacgg ggctgggcat
2760901 cttcatggtg ttcgtggacg tcaacatcgt caatgtcgca ttgcccagca tccaaaaggt
2760961 gtttcacacg ggcgaacaag gtctgcagtg ggcggtcgcc gggtacagcc tgggcatggc
2761021 ggccgtgctg atgagttgcg ccctgctggg cgatcgctac ggtcgcaggc gcagttttgt
2761081 gttcggggtc acgctcttcg tcgtgagctc tattgtctgt gtgctaccgg tcagcctggc
2761141 agttttcacg gtcgcacgag tgatccaagg tttaggagcg gcgttcatct cagtgctctc
2761201 gctggccttg ctaagccact cctttcccaa tccccgaatg aaagcacggg cgatatccaa
2761261 ctggatggcc ataggcatgg tcggtgcggc atctgccccc gcgctgggcg ggctcatggt
2761321 cgacggcctc ggttggcgca gcgtgttcct ggtgaacgtt ccgctcggtg ccatcgtgtg
2761381 gctgctgacg ctagtcggtg tcgacgagtc acaggatccc gagcccactc aactcgactg
2761441 ggtgggacag ctgacgctta tcccggccgt cgccctgatc gcatacacca tcatcgaggc
2761501 tccccggttc gaccggcagt ccgccgggtt cgtggcggcg ttgctgttag cggctggggt
2761561 actgctgtgg ctgtttgttc gacacgaaca ccgcgccgct ttcccgttgg tcgatctcaa
2761621 actgttcgcc gagccgttgt accgatcggt gctgatcgtc tacttcgtgg tgatgtcctg
2761681 ctttttcggg actctgatgg tgatcaccca gcacttccaa aatgtgcgcg acctatcgcc
2761741 gctgcacgcg ggtttgatga tgttgccggt ccccgcggga ttcggggtgg cgagtctgct
2761801 ggcgggtagg gcggtcaaca aatggggtcc tcagctcccg gtgctgacgt gcctggcggc
2761861 catgttcatc gggttggcga ttttcgcgat ctcgatggac cacgcgcatc cagtggccct
2761921 tgttggcctg acgatctttg gcgcgggagc cggcggctgc gccacaccgc tgttgcatct
2761981 tggaatgacc aaggtcgatg atggccgtgc cggcatggcc gccgggatgc tcaatctgca
2762041 gcggtcgctg ggcggcattt tcggcgtcgc cttcctgggc accattgtcg cggcctggtt
2762101 gggtgccgcg ctgccgaaca ccatggccga cgaaattccc gatcccatcg ctcgcgcgat
2762161 cgttgtcgac gtcatcgtgg acagcgcgaa tccgcatgcc cacgcggcat ttatcgggcc
2762221 aggacaccgg ataactgcgg cgcaggagga tgagatcgta ctggccgccg acgcggtctt
2762281 cgtgagcgga atcaagctcg cgttgggcgg cgccgccgta ttgctgaccg gcgcgttcgt
2762341 ccttggttgg acgcgcttcc cccggacccc cgccagctaa gtggtctcgc tcggtgcgcc
2762401 cccacagtcc ctgcgccgag atcgacgtta gcgtcacgcc ttatggtgat tttccgctct
2762461 ggcgtggatc tcggcgcatg tcgggtggcg accaccaagc cacgccacgg ccgcaccacc
2762521 cgcccatggc tcaggcggtt tgcgcggaga gcttccggta ctcgagcacc gtgtcgatga
2762581 tgccgtagtc cttagcctct tccgcggtca agatcttgtc ccggtcagtg tctttgcgga
2762641 tcactccggc gtccttgccg gtgtggcggg ccagcgtggt ttccatcagg gtgcgcatcc
2762701 gctcgatctc ggcggcctgg atctccagat cggagaactg tccctggatc acgcccgaca
2762761 acgacggctg atggatcaac acccgcgcat tcggcagcgc catgcgcttg cccggtgttc
2762821 cggcggccag cagcaccgca gccgccgagg cggcctggcc cagacacacc gtctggatat
2762881 cggcccgcac gtattgcatg gtgtcgtaga tcgccatcag cgaggtgaac ccaccgcccg
2762941 gcgagttgat gtacatggtg atatcgcggt cgggatccaa cgactccaac accagcaact
2763001 gtgccatgat gtcgttcgcc gacgcgtcgt cgacctggac gccgaggaag atgatgcgtt
2763061 cctcgaacag cttgttgtat ggattggact ccttgacccc gaagctggag tgctcgatga
2763121 acgacggcag gatgtagcgc gcctggggct ggatctgaga attttgggaa ttcactgtgc
2763181 ttctccattg acgtgggcgc gggtgatgat gtgatcgacg aaaccgtatt ccagggcttc
2763241 ggcggcggtg aaccagcggt cgcgatcgga atccgcctca atgcgctcga tcggctggcc
2763301 ggtgaattcg gcgttgagcc ggaacatttc tttcttgatc acggcgaact gctcggcctg
2763361 gatggcgata tcggccgcgc tgccggtcac cccgcccaac ggctggtgca tcaggatgcg
2763421 agcatgcggc agcgcgtagc gcttgccctt ggtacctgcc gccagcagga actcgcccat
2763481 cgaggcggcc atgcccatcg cgtaggtggc gatgtcacag ggcgccagca ccatggtgtc
2763541 gtagatcgcc atgccggcgc tgatcgatcc acccggcgaa ttgatgtaga ggctgatgtc
2763601 cttgctggcg tcttcggcgg ccagcagcag aatctgagcg cataaccggt tggcgatctc
2763661 gtcgttcacc tccgagccca ggaagatgat gcgctcggag agcaagcgct cgtagaccga
2763721 atccgtgagg ctaagaccct gcgagttcga acgcatgtca gtcacttggc tcacagtggg
2763781 gcacctgctt tcctcgagtt cttctatgct ccgacactaa ccaaccaggc tggctgtttc
2763841 gcggtcacgc accccctgaa accggcgcgt tcgcttacag cgtcatacgg tcacgttgtc
2763901 gcttcgtcgg acgccgcccg cgcggcaccc tcgtctgccg gttcggcctc ctcagcctca
2763961 ccggccgaca cacgcttgcc gaagaactca ctggtatcga tcgtgtttcc gtcactgtcg
2764021 gtgaccgtcg ccgcctccac tgcggccctg atcgccagct cgcgccgcac gtcagcgaac
2764081 atggtcggca gctggttgcg ctcttggagg tagccgaaca gctgctgcgg ctcgatgccg
2764141 tattgccgag acgtcgtcac cagtcgttcg gtcagatcat cctggccaac ttggacctgc
2764201 agctcatcgg ccagggcgtc tagcaacagc tgcctcttga cgtccttttc tgaggcggtg
2764261 cgcgcctcgg catcgaacgc cgcgcgtgac gagccttgct cgacgagcaa ctcattgaac
2764321 cgggcttcgt cgtgattaag accgctgagc gcgctgtgca gcacgctgtc gaattgggcc
2764381 tgcacatacg actccggcaa cggcacgtcg acctgttcga gtagcgcatc gatggtggcg
2764441 tttcgaatct gctcggcctg ctgggcgcgc ttggcctggc gcacctggtc gctgaggctg
2764501 gcccgcaatt cgtcgatgct gtcgaactcg ctggctaact gcgcgaattc gtcgtcgggc
2764561 tctggtagtt cgcgctcctt aaccgacctg accgtgacgg taacctgagc ttcctgcccg
2764621 gcgtgctcgc cggctgccag cttggcggtg aagacccggg actcgtcggc ggacagacca
2764681 acaaccgcgt cgtcgagacc tgcgatgagc cggccggagc cgacctcgtg ggagagtccc
2764741 tcagcggctg cgttcggtat gtcctctccg tcgaccgtgg cagacaagtc gatcgagacg
2764801 acgtcgccga cggccaccgg ccggtccacc gcggtcaggg tgccgaaccg ggtacgtaac
2764861 gactgcagtt cggcgtcgac gtcgtcctca ccgatttcga tcggatccac cgagaccgtc
2764921 agcgcgctca ggtccggggg actgatcttc gggcggatgt cgacctcggc ggtgaattgc
2764981 aggtcctggc cgtactcctt cttggtcacc tcgatgttgg gccggccgag cggttggaca
2765041 tccgactcgg ccaccgcctg tccgtaccgg ctgggcagcg catcgttgac gatttgatcc
2765101 agcatggcct cccggccgat gcgggcttcg agtagtttgg ccggcgcctt cccgggccgg
2765161 aagccgggca gccgcacctg tttggccagc tctttgtagg cccgctggaa atccggctca
2765221 agctcggcga atggcacctc cacgttgata cgaacccggg tggggctcaa ctgctcgacg
2765281 gtgctcttca cgggtgtgct ccttggtagt cgataacggc ggtcggctgg tcggggtgac
2765341 aggatttgaa cctgcggcct tccgctccca aagcggatgc gctaccaagc tgcgctacac
2765401 cccgcgctga cctcgcgatc ctacggcccg gcgacaccgg caccgcaatg acctcttgag
2765461 acctcacggg aaggtctcaa aacgactccg attagatttg atgtctgtca ccacgtacag
2765521 tcgcgctcga ctaaatacat gcgggcgtag ctcaatggta gagccctagt cttccaaact
2765581 agcgacgcgg gttcgattcc cgtcgcccgc tcgggccatg cgtttgttcg gcagaaaggc
2765641 gccatgcgcg acccatgaat cagcctgaca tcaagggctc gtgcgcgtcg gagttcacca
2765701 aggtacgcga cgcgttcgag cgcaactttg tgctgcgcaa cgaggtcggc gcggccgtcg
2765761 cggtgtgggt cgacggggat cttgtcgtca acctgtgggg cggctccgcc gacgccggcg
2765821 gtacccggcc ctggcagcac gacacgctgg ccaccgtgct gtccggtacc aaggcactaa
2765881 cggccacgtg tgtgcatcag ctcgtcgatc gcggtgagct tgacctgcat gcgccggtgg
2765941 cacgctactg gcccgagttc ggacaggcgg gtaagcaggc catcacgctg gcgatggtga
2766001 tgagccaccg ctccggggcg atcgggccgc gcggacggct gggctgggag caggtcgccg
2766061 attgggattt tgtctgcgag caactggccg ccgccgaacc gtggtggcag ccgggtgccg
2766121 cgcagggcta ccacatgacc accttcggtt tcatcctcgg cgaagtgttc cgccgcgtca
2766181 caggccgtac ggtcggtcaa tacctgcgta ccgagatcgc tgagccgctg ggtgcggacg
2766241 tccacattgg cttgcatccc ggcgaacagc tccgctgcgc cgatctagtt gataagccgc
2766301 acatccgcca attgctggcc gacgtccaag cccccggcta ccccaccagc ctaaacgaac
2766361 atcccaaggc tgcattgtcg gtgtcgatgg gcttcgcccc cgacgacgaa ctcggctcca
2766421 acgacctgca gctgtggcgt cagatcgaat tccccggcac caacggccag gtgtctgcgc
2766481 tggggctggc gacgttctac aacgggcttg cccaggagaa gctgctcagc cgcgagcaca
2766541 tggagctggt ccgggtctca cagggcggct tcgacaccga tctggtgctc ggcccgaggg
2766601 tcgccgacca tggctggggt ctgggctaca tgctcaacca gcgcggcgtc aatggaccca
2766661 acccacggat tttcgggcat ggtggcctcg gcggctcgtt tgggttcgtc gacctcgagc
2766721 accggatcgg ctacgcctac gtgatgaacc gcttcgacgc caccaaggcc aacgcggatc
2766781 cgcgcagcgt cgtcctgtcc aacgaggtct acgccgcgct cggggtaaac cgttcctaga
2766841 cggctagcca ccaggcggtc aggtctgaca gaccgggcac cagaaaacat tgcggccctc
2766901 gagcagtgcc gtgcggatca ctcccccaca cacccgacac ggctcgccgg ctcggcggta
2766961 cacataggtg cggggccggt cgggcagata tgacggcaga ccatggtcat gttcggggcg
2767021 caccacgatg atcttgccgc ggcgcaagcc caccttcatc aacgacacca gatcgttcca
2767081 ggccgcgtcg aattccggct caccgatccc gcggccgggc cgctgtgggt cgatccggtg
2767141 ccgaaaaagc aactcattac ggtagacgtt gccaacaccg gcgatcaccg tttggtccat
2767201 caagagcgcg cctatgggcc tgcgagactt ggtgatccga gaccatgccg acgacgggtt
2767261 ggcgtcgcta cgcaacgggt cgggtcccag cctggcaacc acgtccgcaa cctcgccgtc
2767321 gtcgatcgac tcacacaccg tcgggccgcg caagtcggtg ccgaattctg ccccgaccat
2767381 ccgcatccgc acctgccccg cgggttcggg tagccaccca tctgtggggc gtgcccattc
2767441 ggtgaaggtg ccatagagcc cgagatgcac gtgcaccacg gggccgccga cgtagtgatg
2767501 gaacaggtgt ttgccccagg cactggcccg ccgcaacacc cgaccgttga gcgcggaagc
2767561 cgaatcggcg aaccggccct gggggctgga caccgagacc ggcgcaccgg cgaaccggcg
2767621 ctggtgcagc cgggccagcc gatgcagcgt atgcccctca ggcacgggag tcaggccgga
2767681 gcgccgggca ccggcggcgc ttcgtgggtc cgttcgtact cggcgagaat gtcgatacgc
2767741 cgttggtggc gttgcgcttt cgaccacggc gtggtgacga aggcgtcgac tatcgccagt
2767801 gcctcggcca ccgtgtgcat gcggccgccg atgccgatca attgggcgtt gttgtgctcg
2767861 cgagccagcg ccgcggtctg cacactccag gccagcgcgc agcgagcgcc gggcaccttg
2767921 ttggcggcga tctgctcccc gttgcccgat ccgcccagca cgatgcccag gctgcccgga
2767981 tcggcgacag tgcgcgtcgc tgcggcaatg cagaatgccg ggtagtcgtc gtcggcgtcg
2768041 tagcgcaacg cgccgcagtc gatcggctcg tggccggttt gcttcaggtg ctcgatgatc
2768101 cgctgcttga gctcatatcc ggcgtggtcg gcccccaggt agacgcgcat gcccgacatt
2768161 gtgcccgaca cactgccggg cgccggcgcg ggcgcccgcc gatagtgaat tcggcgacaa
2768221 gaacccgggc gtgttccggc gccgaattca ctatcggcgg ctagtcgaac tgaggcggct
2768281 cggtgcgggt ccgcttgagc tcaaaaaagt gcgggtagga agcgaaggta accgaggcat
2768341 cccagagctt gccggcttcc tcgccgcgcg gaatcttcga gagcaccggc ccgaagaacg
2768401 ccacaccatt gacatggatc gtcggcgtac cgacgtcctc gcccaccgcg tccatcccgg
2768461 cgtggtggct tttgcgcagg gcgttgtcgt aagcgtcgct ggtagcggcc ttggccaact
2768521 ccgcgggcag accggcgtcc gccagcgact gggtgatgac ctcgtcgagt tcgtggttgc
2768581 cctggttgtg aatccggttg cccatcgcgg tgtacagcgg gtccaggact ttcgccccat
2768641 gggcctgctc ggcggcgatc gccacccgta ccggtcccca tgccctcgcc atgccttcgc
2768701 ggtattgctc gggcaggtcg tcacggtttt cgttgagtat tgccaggctc atgacgtgga
2768761 agttcacctc gatgtcgcgg acctttgcca cctcgaggat ccagcgcgac gtgatccagc
2768821 accacgggca cagcggatcg aaccagaaat cggcgacaga cttctggggg gccttctcga
2768881 gcatggcgcg gtcctctcgt tggagtcagc agcggtgagt acaccgccca gcacaaccac
2768941 ggccgccccg cacctgttcc cgccgacccg gttaagttgg acgccgtggc ccttccaaac
2769001 ctcacgcggg accaagccgt cgaacgcgcc gccctgataa ccgtggacag ctaccagatc
2769061 attctcgatg tgaccgacgg taacggcgct cccggcgaac gcaccttccg gtcgaccacc
2769121 accgtggtgt tcgacgcact ccccggcgcc gacacggtca tcgacatctc cgcccacacc
2769181 gtgcgccgcg ccagcctcaa cgaccaagac ctggacgtct cgggatatga cgaggcggcc
2769241 gggatcccgt tgcgcggact ggcccagcgc aacgtcgtcg tcgtcgacgc cgactgccac
2769301 tactccaata ccggcgaggg cctgcatcgg tttgtcgatc cggtggacgg cgagacctac
2769361 ctgtactcgc aattcgaaac cgccgacgcc aagcgcatgt tcgcctgctt cgaccaaccc
2769421 gacctcaagg ccacgtttga cgtgcgggtg accgcgcccg cgcactggaa ggtgatctcc
2769481 aacggcgcgc cgctggccgc ggcaaacggc gtacacacct tcgccactac cccgcggatg
2769541 agcacctatc tggtggcctt gatcgccgga ccatacgcgg cctggacgga cacttacatc
2769601 gacgaccacg gggaaatccc actcggcatc tattgccggg cctcgcttgc cgaatacatg
2769661 gacgccgagc ggctgttcac ccaaaccaag cagggattcg gcttctacca caagcacttt
2769721 ggcctgccat acgcgttcgg caagtacgac cagctcttcg tccccgaatt caacgccggc
2769781 gcaatggaaa acgccggcgc ggtgaccttc ttggaggact acgtcttccg cagcaaggtc
2769841 acccgggcat cctatgagcg gcgcgcggag accgtgctgc acgagatggc ccacatgtgg
2769901 ttcggcgacc tggtcaccat gacctggtgg gacgatctgt ggctgaacga gtccttcgcc
2769961 accttcgcct cggtgctgtg ccaaagcgag gccaccgaat tcaccgaggc ttggacgacg
2770021 tttgcgaccg tggagaagtc ttgggcgtat cgccaagacc agctgccgtc gacgcacccg
2770081 atcgccgccg acatccccga cctggccgct gtcgaggtga acttcgacgg gatcacctac
2770141 gccaagggcg cctcggtgct caaacagctc gttgcctacg tcgggctgga gcgctttctg
2770201 gccggcctgc gtgactactt ccgcacgcac gcttttggca atgccagctt tgacgatctg
2770261 ctggccgcgt tggaaaaggc ctcgggccgc gacctgtcga attggggcga gcagtggctg
2770321 aagacgaccg ggctcaacac cctgcgacca gatttcgagg ttgatgccga gggcaggttc
2770381 acccggttcg cggtgacaca gagcggtgcg gcacccggcg caggtgagac cagggtgcat
2770441 cggttggcgg tgggcatcta cgacgatgat ggttccaaga gttccggcaa gctggtccgg
2770501 gtgcaccgcg aggaactcga tgtctccggt ccgatcacga acgtccctgc gctggttggc
2770561 gtttcgcgcg ggaaactgat tctggtcaac gacgacgacc tgacctactg ttcgctgcgg
2770621 ctggacgagc ggtcgctaca gaccgcgcta gaccgcatcg ccgacatcgc cgagccgctg
2770681 ccgcgcacgc tggtgtggtc ggccgcctgg gaaatgaccc gtgaagccga actgcgtgcc
2770741 cgcgacttcg tgtcactggt gtccggcggc gtgcacgcag aaacggaggt cggggtcgcg
2770801 cagcggctgc tgctacaggc gcagacagcg ttgggttgct atgccgagcc cggctgggcc
2770861 cgggagcggg gatggccgca gttcgccgac cggctgctgg agttggcgcg cgaagccgag
2770921 cctgggtcgg atcatcagct ggcctatatc aactcgctgt gttcgtcggt gttgtccccc
2770981 cggcatgtgc agaccctagg ggcgttgctc gagggtgagc ccgccgcatg tggattggca
2771041 ggcttagccg tcgacaccga cctgcgctgg cggatcgtaa ccgcgctggc caccgcgggc
2771101 gccatcgacg ccgacgggcc ggagacaccg agaatcgacg ccgaggtgca gcgcgacccg
2771161 actgccgccg gaaagcggca tgccgcccag gcccgcgcgg cgcggccaca gttcgtcgtc
2771221 aaggacgagg cattcaccac ggtggtcgag gacgacaccc tggccaacgc cactggccgc
2771281 gcgatgatcg ccggcattgc cgcacccgga caaggcgagc tgctcaagcc gttcgcgcga
2771341 cgctactttc aggcgatccc cggagtatgg gcacggcgat ccagcgaagt cgcgcaatcg
2771401 gtggtgattg gcctgtatcc gcactgggac atcagcgagc agggcatcac cgccgccgag
2771461 gagttcctca gcgaccccga ggttccgccc gcattgcgcc ggctggtgct cgagggccag
2771521 gccgcggtgc agcgatcgtt gcgggcccgc aacttcgacg ctgacggcta gccctcaccg
2771581 cgagggcgcg tgtctgtaca acgacacgcc gcatcgggcg tacattcggg cgtgctcgcc
2771641 gggtcagccc ggcgcgatcc ccgcgctgag cacgcggatc gcgctgatca gcccatctac
2771701 cagctcaccc tgctcgaacg ctgaggaagc ggcggcaacc ccgagcggag ccgccgactc
2771761 ggcaccgcgg ccgcggactt gcgagccgta gaccacttcg atggcgcact ggttgggcga
2771821 gaccgcgagc agcacagcat tgtccggcgt gggcaccttg cccaagatct cgcgggcccg
2771881 cgcggcggtg tcacgaccca agtcgccgag gtagatggcg aacctcacct gacacgcccg
2771941 cgagctgtag gtcagcgcgt cgtccagggc gacgagatct gcgatgggga acgggtagtg
2772001 cacggacagt tccccgggct cggtgacccc cgagatccgt ccgctggtgg tcagcaccca
2772061 acccggcggc agctcggcgt gctcaatcgt cgcaacgtca ccacgtgcca ctggccccac
2772121 ctccaaccgt gaactccgat gcgtcatgcc cgtgtccgcc gtgcgcgctg ccaacgacct
2772181 cgtcggtggc ggcccacagg atgggcgggt gtgtccaagg ctccgacagt ttgtaggttg
2772241 ccgggtgagg tcccttgcgc gaccagatca gcacagacag cacaaccacc agcaacaacg
2772301 ggataccgac aaagaagagg tggatctcca tagcactcac gacgcaaacc gtatcccacc
2772361 gggttttcag gccgcaccct caccgaggta tcgcgcccag gacgggtcca gctccttgac
2772421 cgccgacagc agtcgccagt gcggtcccgt gggcggcagc ggcgcccggc ggagtgccca
2772481 gccaagctcg gtcaacagcc tgtcaccctt gcggtggtta cacggcgagc agcacgcaac
2772541 gcagttctcc caggagtggg caccgccccg gctgcggggt accacgtggt cgacggtgtc
2772601 ggccttgccg ccgcagtagg cacaacagaa ccggtcccga tgcatgagcg cggcccgggt
2772661 catcggaacc cgggcacggt agggaacccg gacataggag cgcaactgga tcaccgacgg
2772721 gaccaggatc gatctggtcg ccgagtggat gaccggcccg gacgggtctt cgtgcaccac
2772781 gtcggccttg ccacagatca ccatgacaat cgcccgccgc atcgacaacg cggtaagcgg
2772841 ctcgtaggtg gagttcagga gcagcacccg ccggcggttc cagatcgatg cgctctcgtg
2772901 acggttcggt ggatgggtct cgacgcctga cgcgagtcgg tgggagtgga cactgtgcag
2772961 gcatgaagcg ggcccggtta cgcctgccgc gacaccggaa ctgcggtggc cgcggcgctt
2773021 cttgccgtgc gccataggtc ctccgccgaa cagtccacca tgattcgcgg ctaatcgcac
2773081 gccaaatgcc acgtccacac cgtgtcgctc cggtgaacaa accgggggct ggctggtcgg
2773141 ccacgacaaa tagaccacaa tggaggggat ggatcagatg ccgaagtctt tctacgacgc
2773201 ggtcggcggc gccaaaacct tcgacgcgat cgtgtcgcgt ttctatgcgc aggtcgccga
2773261 ggacgaagta ctgcggcggg tgtaccccga agatgactta gccggcgccg aggaacgatt
2773321 gcggatgttc ctcgagcagt actggggcgg cccacgaacc tactcggagc agcgcggcca
2773381 cccccgattg cggatgcggc atgccccgtt tcggatctcg ctcatcgaac gcgacgcctg
2773441 gctgcggtgc atgcatacgg ctgtggcctc catcgactca gaaacgctcg atgacgagca
2773501 ccgtcgagag ttgctggatt atctggagat ggccgctcac tcgctggtca actccccgtt
2773561 ttgatggacc aacaccagcg accggatcca atgggccccg gctctcctcg cgccagcgct
2773621 cgtcgaccgg agccagatcc gatgggcgag ccgtggtggt cgcgagccgt gttctaccag
2773681 gtctatcccc gatcgttcgc cgacagcaac ggcgacgggg tgggcgacct ggacgggttg
2773741 gcgagccggc ttgaccacct gcaacagctc ggtgtcgacg cgatctggat caacccggtc
2773801 accgtctcgc cgatggcaga ccacggatac gacgtcgccg atccccgcga catcgaccca
2773861 ctcttcggcg ggatgccggc gttcgaacgg ttggtcgctg cggcacaccg gcagggcatc
2773921 aaagtcacca tggacgtggt gcccaaccac accagttcgg cgcacccatg gtttcaggcc
2773981 gcgctggctg acctcccggg tagcccggcg cgggatcgct atttctttcg cgacgggcgg
2774041 ggccccgacg ggtcgctgcc gccgaacaac tgggagtcgg tgttcggcgg gccggcctgg
2774101 acccgagtgc gcgaaccgga cggcaacccg ggccagtggt acctgcacct tttcgacacc
2774161 gaacagccgg acctgaactg ggacaacccg gaaatccttg acgacttcga gaaaacactg
2774221 cgcttctggc tggaccgcgg cgtggatggc ttccgcatcg acgtggcgca cggcatggcc
2774281 aagcccccgg gcctgccgga ctcaccggac ctgggcatcg aggtgctgca ccaccgcgat
2774341 gacgacccgc gcttcaacca cccgaatgtg cacgcgattc accgcgacat ccgcacggtg
2774401 atcgacgagt accccggagc ggtaaccgtc ggcgaggtgt gggtacacga caacgcccgc
2774461 tgggcggagt atctgcggcc cgacgaactg catctcggct tcaatttccg gctggcgcga
2774521 accgagttcg acgccgccga gatccgcgac gcggtggcga actccctggc cgccgcggcg
2774581 ctgcagaacg cgaccccaac ctggacgctg gccaatcacg atgtgggacg ggaggttagc
2774641 cgctacggcg gcggcgagat cgggctgcgc cgggccaagg cgatggcggt ggtgatgctc
2774701 gccctgccgg gcgtggtctt cctctacaac ggccaggaac tgggtttgcc cgacgtggac
2774761 ctgcccgacg aggtgctgca ggatccgacg tgggaacgct cgggacgcac cgaacgcggt
2774821 cgcgatggct gccgggtgcc gattccctgg tcgggcaaca ttcccccgtt cgggttctcg
2774881 acgtgtccag acacctggtt gccgatgccg ccggaatggg cggcgctgac cgccgaaaaa
2774941 caacgcgctg atgccggctc gaccttgtcg ttttttcgac ttgcactcag attacgtagg
2775001 gaacgaaatg aattcgacgg cgacgtcgac tggctggccg cgcccgacga tgcgctgata
2775061 ttccggcgtc acggcggggg tttggtgtgc gcgctcaacg ccgctgagcg tccgctggcg
2775121 ctgccggcag gtgaacccat cctggccagc gcaccgttga ccgacgccac gttgccaccc
2775181 aatgccgcgg cctggctggt gtagcggcat tccgagctat gcctgcccga catataagcg
2775241 catacgcatc ctaggcgggc accgtctagg tatgatgatg cggatcgccg tgcggctacc
2775301 cggggaagtc atcaccttcg tcgatagcga ggtcagccaa atccgcatac ccagccggcg
2775361 cgccgcagtg gtgttgcgtg cctcgaacgc gagcgacgcc gcgattctta ccgccaccga
2775421 acccaatcac cacctcgacg cactcgccgg acaggccgca aagctagcac caacatcgat
2775481 tgatgcggct catccagctc gcccagctag acgagacccg tgcctttacc cgcgaactgg
2775541 ccaggcctta cctcgcaccg ggtaaccgtg gcacccacct cgagcagcgt agccagcgaa
2775601 ctgctcatgc cctggccgag cgctgccgct agcggtgtgg tcggctggcg caccaccgcg
2775661 accgccagtc agcgatacca tcggccgatg tcggatactc cgttcgccga gccctatccc
2775721 gagcagcggc ccccctgggg tgtcccgcca ccaggttggg acggatcgtc gcggccagcg
2775781 ccctcgacga ctcctcgatc gcccgggcgg tggtctctag tggcggccct agcccttgcg
2775841 gtcgtctcat taggcgtggg catcgtcgga tggtttcatc ggcaaccgca cgacaagcca
2775901 tcaccggccc catccgcgcc gacgttcacc agccaacaga tttccgacgc gaaagaaaac
2775961 gtctgcgccg cacaccggat cgtgcgccag gcggccgtgc tgaataccaa tcaggccaac
2776021 ccggtacccg gagacccgac cggcgatttg gcggtggcag ccaacgcccg cctggcgctg
2776081 tatagcggcg gcgactacct gctgaggcgt ctcaccgccg agccagcgac tcctgccgag
2776141 ttgcgcgatg ccgtccgctc gctcgccaac gctctacaag agcttgcagt gaactatctc
2776201 gctggagctc ccgattccgt ggtaactccc ctgcggctgg cgctggaaag ggacaccaga
2776261 gccgtggatc cgctatgcgt gtgacggcga tccggaaatg aaccatcctc gcccatcagc
2776321 gcagcaccag cgccgcgtgg ccgcgatgcc gataaaccga gccgaagcgg gcgtccagac
2776381 gcaaccacgc cggcgatatc cggacccgga tcagctcgtc ggcgctgatc gtttctgcgg
2776441 actggggaag gaaacccatt gcggtcaaag cgaacacaca gcgcatgggt agcccaacga
2776501 cgacatcggc cgagctgacc tggatgacct cctgatcgag cagcgatacc ggcggaccag
2776561 ccgaactccc gtgctccttg gccagccgcg cgccacggtg cgccaggtcc aacatcaccc
2776621 gggccggtac gtcgtcgaga taggtgaagc cggactccgg cggcaaccca ccccgccacg
2776681 cggagtccat cgagtaaccg ggatcgacat agcccgaggc atccgttgtg gccagaccgt
2776741 gcgcgagtga ccgtgcggcc accgacagat cgtcgggtcg caccttgccg gccaccaccc
2776801 gactggccag cacgtcgaag cccgttgcta cccaagccga tagcaatccg gtagaccgcg
2776861 cgcgaatacg gataacggcg gcatcgtcga gccgaagcgc gtgatccacg aacgtggcca
2776921 gatccgcgcg gtgagccggg tcagggagcc acaacccacg ctcaaccacc ccgcctatcc
2776981 ccgaaaccac cgttgcaggt actcgcgatg gtgtggcgat agtcgaacca accgctgttc
2777041 ctcgatatgg aacgcggcca gctgcgactc ggcgatgacc gcaggcctcg agtctggctc
2777101 cgcgttgacc gaccgcacct cgtacccgag cgtgaagtcg accgcccgca gccgcttggt
2777161 ccagatcgtc acctgtagcg gcgagtcgga caaccgcagt tgacccttgt aggtcacccg
2777221 gacatcggcg atcagcagcc cggtggacgt gatgtcggct ccgaaagcat ccttaagaaa
2777281 cgggacccgt gcctcttcga gaatcgtgac catggtggcg tggttgacgt gctgatacat
2777341 gtcgatgtca gaccagcgca cccccaccgg cgtgacgaac ccgacgctca ccccgagatt
2777401 cctcgcccgc ttgtccgtgt catgcggcgg atctgccgcg cggcgaccga caacgtcgcc
2777461 agatccttct ggccgctggc acggatgtcg tcgagtgtcc gacgtgcccg cgccacccgg
2777521 gaggcgctga ggtgttccca ctcggcgatc ttttgctcgc tactctcgcc gggttccccc
2777581 acggccagca cgtcgaaaca caacgaccgt agcgcaccgt aaatatcgtc gcgaatcgcc
2777641 aagcgcgcca acgaatgcca gcggtcgtgt cggggcagct gggataccgc ggtcagcagg
2777701 ccatcggtgc ccagccggtc catcagggcg aaataggtgt cagcgacctc ggcggcgtcg
2777761 atgtcggcga tgtcggcgat gtcgatgatg tcgagcaggc tgtaccggta caggccggtc
2777821 gagacacggt aggccaagtc ttcaggcaca ccctgcgatg cgaattccgc agctgtcttt
2777881 tcgacgatgg ccttgtcatc accacgcaac cactccgaca tgcgcggtgt cagtgccttg
2777941 accatggccg cgaatcggtt gatctcggcg ccgacggcca agggctgcgg acggtagttg
2778001 agcagccagc gtccggcacg gtcgatcagc cgacgggtgt ccagcgtcaa cctgtctgac
2778061 agcgcgattg gcaggttcgc cgcacggatc cggcgccaaa tgtgaccgac accgaagatg
2778121 gcatcggtgg cgacataggt gcgcacggca tcgatcggcg tgacaccaac gtcttcggcg
2778181 atccggaacg cataggtgat gccggcggta tccaccagat cgttgatcag catggtggtg
2778241 acgatctcgc ggcgcagctg gtgggaacgg atctccgggg tgaaccgttc gcgcagcgcc
2778301 gtcgggaaat aacgaggcaa cctggaagcg aagacatcct gatccggtag ttcggtggct
2778361 agcacctcct ctttgagccc cagcttgacg tgcgccatca gcgtggcgag ttcgggcgag
2778421 gtgagcccga tgccggcctc ggagcgccgg gcaatctcct tctccgacgg cagcgcttcc
2778481 aattcgcggt tgaccccgcg ctcagccacc aaatacttga tctgcattgc gtgcaccggc
2778541 agcaggctgg ccgcgttggc gcgactggtg cccatcaagt cgttctgatc ttcgttgtcg
2778601 gcgagcacca gttgcgctac ctcgtcggtc attgactcga gcagctgtgt gcgttcgtcg
2778661 gctttgaccg tgccggcgct caccagcgag tcgatcagga tcttgatgtt gacctcgtgg
2778721 tccgagcagt ccacgccggc ggagttgtcc agcgcgtcgg tgttgatccg gccgccggac
2778781 agatcgaatt cgacacggcc caacgccgtc actccgagat tgccaccttc gccaatgacc
2778841 ttggcgcgca cttgattcgc gttgactcgc accggatcgt tggcgcgatc gccgacatca
2778901 gcatccgact ctgactcggc cttgatgtaa gtgccgatgc cgccgttgaa cagcaggtcc
2778961 accggcgccc gcagaatcgc ccgaataagg ttgggcgggg ccatctcggc ggcccccccg
2779021 tcaactgagc cgtcgatgcc gaggacggcg cggacctgcg cgctgagcgg gatggctttc
2779081 tgttcgcggc tgtacacccc gccgccctcg ctgatcagag acctgtcata gtcgctccag
2779141 ctggaccggg gcaactcgaa catccgccgg cgttcggccc acgacaccgc ggcatcgggg
2779201 ttggggtcga ggaagatgtg gcggtggtcg aaggcggcga tcagccggat gtgcttgctc
2779261 agcaacatgc cgttgccgaa tacgtcgccg ctcatgtcgc cgattcccac gacggtgaaa
2779321 tcctgggtct gggtgtcgat cccgatctct cggaaatgcc gttttacggc ctcccaggcc
2779381 ccccgggcgg tgatgcccat ggccttgtgg tcgtagccca ccgatccgcc cgaggcgaac
2779441 gcgtcgccca gccagaaccc ataggacttg gcgacatcgt tggcgatatc ggaaaaggtg
2779501 gcagtacctt tgtcggcggc cactaccaag taggcgtcgt cgccgtcacg tcgcaccacc
2779561 tcgggcgggg ggttgacgct tgcggtcgca tgatcgacgt tgtcggtgac atcgagcaac
2779621 ccggagatga acagctgata gcaggcgacc ccttcggcgc gggtggcgtc gcggtcggcg
2779681 gcggggtcgc cggtgggcag cgggggacgc ttgaccacga acccgccctt ggccccgacc
2779741 ggcacgatga cggcgttctt caccgcttgc gccttgacca atccgagaat ctcggttcgg
2779801 aaatcgtcac ggcggtccga ccagcgcaac ccgccacgcg caactgggcc gaacctcaga
2779861 tgcacgcctt cgacgcgggg cgaatacaca aaaatctcgt accggggacg cggcagcgga
2779921 agttcgtcga tcaactgggc attgagtttc agcgccaata catcacggca gcgggccgaa
2779981 ccctggcgtg tcacaaagta attggtgcgc aacgtggcct gaaccaacga cgcgaaggcg
2780041 cgcaggatcc ggtcggtgtc caggctcacc agcgcgtcga tgtccgcggc gacagcggca
2780101 gcggccgctt gggcatcgcg attgctcgcc gaccccgacg gcaccggaac gaaaagcgct
2780161 tcgaacagat cgaccaaaga ccgaacggta gcagggtgct cgttgagcac cgattcaatg
2780221 taggactggc tgtacgggaa gcccgcctgg cgcaggtact tcgcgtaggc acggagcagc
2780281 acgacctgct gccaagtcag cccggcacgc atcaccagct cgttgaatcg gtcgatttcg
2780341 acccggccgt gccagatcgc ggtcaccgcc tcggcgaatc ggtgcgcggt cgcggcccgc
2780401 tcggcaaccg tcggggccaa cgggatcgtg ggatgcggcg agatcttgaa ctgatagatc
2780461 cagaccggca gaccgtccgg ccgggtgacg gagaacggtc gctcttcgag caccacgact
2780521 cccatgcttt gcagcatcgg cagcagctgg ctcagcgaag cggtgcgccc accgaggaac
2780581 caggtcaact gggcgacacc ctgctcgtcg cgttcggaaa acaccagctt gaccgaatcg
2780641 tcggtcagct ccgtgatgac cgcaatgtcg ccaatggcat cggccggggt gacggcctgt
2780701 ttgtaggcct cggagaaggc ggcagcgtaa tgcatagcgt cggcctgtcc gacggagcca
2780761 gccgccgccg ccgcgccgat caaacggtcg gcccaggttc gcgcggcttc ggtcagcaga
2780821 ccctggatcc ggatccggtt ggcttcggaa acgtccaccg gcggggcggc cgccccttct
2780881 cctgccacac ccacttcggg tagccgcacc atgaaatgca tgagtgccca aggtgattca
2780941 ctgacccgag cggtgaactc cagtcgtgtt cccccgaact cgcggacaag gatgtcctcg
2781001 aattgcatgc gcacggcggt ggtgtagcga tctcggggca tgtagaccag gcacgacacg
2781061 aagtactgca accgatccgc gcgcaggaac aacaacgcct gccgttgcga tcccaagtcc
2781121 accacggccc tggccatggt cagcaggcgc tgcgcgctca gggtgaacag ctccggtcgc
2781181 gggacggtct ggatgacgtc gagcagcaat tggcctgggt ggctgggatc gctttcggcc
2781241 atcgccagcg cctcgcggac ccggcgcgag atcgtcggga tctccagcac gtccgcattc
2781301 atggccgcga cgctgaagag cccgacgaag cggtgctcga ccacgctgcc gtcgacgtat
2781361 tcgcggaccg cgatggcata gggataggcg ccgtaacgca ggtagctgcc gacccgcgct
2781421 tgggccaaca ccagcagttt gtcgtcgtcg gtcagccggg gacgcgaacc ggtgcggccc
2781481 cgcaggacgc ccataccgct tgacccctcg ccgtagacca tcccgtcagc cacccggcac
2781541 cgttggtagc ccagcagcag gaagttcccg tcacccagcc aacgcaacag ttccccgacg
2781601 tcttgtcggt cgggcgcgga aaatcggccg ccggcattgg attcgacttc tcccgccagc
2781661 tcgctcaggg tggcgatcag cgctgtggcg tcggtggcca cccgctggac gtcggccagc
2781721 accttgggca gcaaccgctc cacctcggcg aggcctttgt gatcaacggc gggcgagagc
2781781 gctacgtgca tccaggcctc acccaggtgc ggcgacgtgc cctcggcctt cggttcgatg
2781841 cgcagcagct ctcccgtggg gctgcggtgc acgtcgaaca ccggggtcag aatcgccgcg
2781901 taggcgattc caagccggtg cagcagcacc gtaacggaat ccatcagcat gccgccgtgc
2781961 tcggcgacca cctgcagcgc cggaccgaac cccgcgggat cgtccgcccg atagacggcg
2782021 acacagcttt caccggccgc gcggtgccgg ccaagccgat aatgtgcgcc cagcatggcg
2782081 ggcgtcagca gggaggctgg aagccaactg gcctcggcgg ccttggtggc ttccgacgag
2782141 tcgtcgcgcg gtcctcgata gctgtcgatg taggccttcg agatccagtc aggaatgtcc
2782201 gcactcgcgg tgaacgtggt ccacgcctca acatcctgct tagccccggg atcgatcgtc
2782261 atgccgattg ctcccaactc acgacgggta ccgctcgatt caattttccc gctcctgggt
2782321 gcggcgttcc ggacgcatcg tcacggggcg tgggcgaagc taacattagc cgcgcgtcag
2782381 cttgcggtgg gtgaccctat gcggtcgagc ggcgtcgaca ccgagccgtt ccaccttgtt
2782441 ctcctcgtag gcgccgaagt tgccctcgaa ccagaaccac ttcgcctcgt tgtcgtcgtc
2782501 accctcccac gccaggatgt gcgtgcacgt gcggtcaaga aaccagcgat cgtgcgaaat
2782561 caccacggcg cagccgggga agttcagcag agcattctcc agcgaaccca gagtctcgac
2782621 atccaggtcg ttcgtcggtt cgtcgagcag aatcaggttg ccgccctgtt tgagcgtcaa
2782681 cgcaaggttg agcctgttgc gctccccgcc ggatagcaca ccggccggtt tttgctggtc
2782741 cggtccctta aacccgaatg ccgacacgta ggcccgtgac ggcacttcgg tttgaccgac
2782801 ctggatatag tccagaccgt ccgagacaac ctcccagacg gtcttccgcg gatcgatgcc
2782861 agcacgggcc tggtccacgt aactcagctt gacggtctcg ccgaccttga cgctgccgct
2782921 gtccggtgtc tcgagcccga cgatggtttt gaacagtgtg gtcttgccta ccccgttggg
2782981 cccaatgacg ccgacgatgc cattgcgggg caagctgaac gacaggtcct tgatcagggc
2783041 gcgcccgtcg tagcccttat cgaggtggtc gacctcaacc accacgttgc ctaggcgggg
2783101 cccgaccggg atctgaatct cctcgaagtc gagcttgcgg gtcttctccg cctcggctgc
2783161 catctcctcg tagcgctgca ggcgcgcctt gcttttggcc tggcgcgcct tggccccgga
2783221 ccggacccaa gccaactcct cggtcaaccg cttttgcagc ttcgcgtcct tgcggccttg
2783281 caccgcgagc cgctcggctt ttttctccag ataggtcgag tagttgccct cataggggta
2783341 ggcgcggcca cgatcgagct ccaggatcca ttccgcgacg ttgtccagga agtaacggtc
2783401 gtgggtgacc gccaggatcg caccggggta gctggccaga tgctgttcga gccactgcac
2783461 actttccgcg tctaggtggt tggtcggctc gtcgagcaac aacaggtcgg gtttggacaa
2783521 cagcagtttg cacagcgcca cccggcgacg ctcgccaccg gataggttgg ttaccggctc
2783581 gtcggccggc ggacagcgca gcgcatccat ggcctgctcg agctgcgcgt cgaggtccca
2783641 cgcgtcggcg tggtccagtt cctcttgcag ccgacccatc tcttccatca gctcgtcggt
2783701 gtagtcggtg gccatcaatt cggcgacctc gttgaagcgg tcgagcttga tcttgatgtc
2783761 ccccatgccc tcttccacat tgccgcgaac ggtcttgtcc tcgttcagcg gcggttcctg
2783821 ttgcaggatg cccacggtgg cgccggtggc caggaaggca tcgccgttgt tcggcttgtc
2783881 caaaccggcc atgatccgca agacgctcga cttaccggcc ccgttggggc cgacgacacc
2783941 gatcttggcg cccggataga aactcaacgt cacgtcgtcg aggatcacct tatcgccgtg
2784001 cgccttgcgg accttcttca tcgtgtagat gaactcagcc atgccgcggt gttgcctttc
2784061 tggtccttcg ggttacctcg cgaaccatcc taggcaccgc cggggcagca tcgaggcgac
2784121 ccctaagccg atatgggcag ggggttgtgg ccagtgatgg cgtcgtcgac cacgacatcg
2784181 gaaaccgagt cggctgccga cgctggggcg tcggcggcac cggccgcccc ggtccccgtg
2784241 gcggccggga gatcaccggc gcttggaccg gtgtaggccg gcttttcgat gcgcacgatc
2784301 acgcgcgaca aatccggccc taccgacgtc gcccgcatct ccagcgacga gcgacgaatg
2784361 ccgtcccggt cctcatattc actggtgtac acgtgtccca ccacaatcac cggtgcgccc
2784421 ttgcccaatg ctgcgcccac cccggtgacc agccttcccc agcaattgac ggtgataaac
2784481 agcgagttgc cgggctccca accgccgtcg ctggtgcgcc ggcgcgaatt gctggccacc
2784541 cggaacttga cgacctcttg atcaccgact ttgcggcgct gcaaatcgtt gacgatgtga
2784601 ccgaccacgg tcagtgaacc gccccggtga gtccggagac tctctgatct gagacctcag
2784661 ccggcggctg gtctctggcg ttgagcgtag taggcagcct cgagttcgac cggcgggacg
2784721 tcgccgcagt actggtagag gcggcgatgg ttgaaccagt cgacccagcg cgcggtggcc
2784781 aactcgacat cctcgatgga ccgccagggc ttgccgggtt tgatcagctc ggtcttgtat
2784841 aggccgttga tcgtctcggc tagtgcattg tcataggagc ttccgaccgc tccgaccgac
2784901 ggttggatgc ctgcctcggc gagccgctcg ctgaaccgga tcgatgtgta ctgagatccc
2784961 ctatccgtat ggtggataac gtctttcagg tcgagtacgc cttcttgttg gcgggtccag
2785021 atggcttgct cgatcgcgtc gaggaccatg gaggtggcca tcgtggaagc gacccgccag
2785081 cccaggatcc tgcgagcgta ggcgtcggtg acaaaggcca cgtaggcgaa ccctgcccag
2785141 gtcgacacat aggtgaggtc tgctacccac agccggttag gtgctggtgg tccgaagcgg
2785201 cgctggacga gatcggcggg acgggctgtg gccggatcag cgatcgtggt cctgcgggct
2785261 ttgccgcggg tggtcccgga caggccgagt ttggtcatca gccgttcgac ggtgcatctg
2785321 gccacctcga tgccctcacg gttcagggtt agccacactt tgcgggcacc gtaaacaccg
2785381 tagttggcgg cgtggacgcg gctgatgtgc tccttgagtt cgccatcgcg cagctcgcgg
2785441 cggctgggct cccggttgat gtggtcgtag taggtcgatg gggcgatcgg cacacccagc
2785501 tcggtcagct gtgtgcagat cgactcgaca ccccaccgca aaccatcggg gccctcgcgg
2785561 tggccctgat gatcggcgat gaaccgggta attagcgtgc tggccggtcg agctcggccg
2785621 cgaagaaagc cgacgcggtc tttaaaatcg cgttcgccct tcgcaattcg gcgttgtccc
2785681 gccgcaagcg cttcagctca gcggattctt cggtcgtggt cccgggccgt gcgccggcat
2785741 cgacctgcgc ctggcgcacc cacttacgca ccgtctccgc gcagccaaca ccaagtagac
2785801 gggcgacctc actgatcgct gcccactccg aatcgtgctg accgcggatc tctgcgacca
2785861 tccgcaccgc ccgctcacgc agctccggcg ggtacctcct cgatgaacca cctgacatga
2785921 ccccatcctt tccaagaact ggagtctccg gacatgccgg ggcggttcac agtggcgttt
2785981 cgaacatttg ctcattcctt tcctagttgc gttggcacag ttgcgttggc accgggtgat
2786041 tccgcgaact gcccacgcat atgccgagtg ctattcacct cggccacacc gacatttgcc
2786101 gggatgagac cgtcgccgcg cgcaatcctg tgaatgaagc ggtaactgtg gattaaccaa
2786161 ttaattggcc gcttggcctg caaacctggg aaccagaccg aaacctcgct cagtattcac
2786221 aaaacggtcc aatggggcag ggtgacggcg ataacatccc aatgaccgtg attcttcgaa
2786281 ccatggcgac gtacgggcca cgacaacctg ccatcgaagg ggcgacgaca atgaagacaa
2786341 ggaacccacg gacgctgcta acctggctgc tcggcgcgat agttactggg ttgtacgtgg
2786401 ttttcgctac gggctgccaa ttgcaagcgc ccgcgcctcc cactccggaa ataggttggt
2786461 cgggcccgca ggctccactg ccggcgccgg atgcggcgcc aacgcacctc ggcgtctagc
2786521 cgatcgcggc ggacaagtcg cccggcaccc agggcgagca gggcttcacg acagctagtg
2786581 agctatagac gacttcgtgt tagcgccgct ggcggggacg ttggcgctga tggggatcga
2786641 gttcctcagc tgcccgtgga caagaaccgc accccgcagc gagtcggcat ggacactcgc
2786701 gacgccgcca cgagtctggc ggtgtacgcc cattgcgcgc gtcacgcgcc cactgaccca
2786761 gttcactggg gtgccgttcg ccgtgctcgc ggcggcgctc acggcgctgc atctgacggc
2786821 atggcgcacc gcattcggtt tttctgagcg ctgggaaaat ggccagccgt ctggctcatg
2786881 gcgtctacgc aacgccacgc ccccaacacg ttcttagatt cggtcgcgtc cttgacgcgc
2786941 tttgaactcg caggcgacga actggttgcg cgcgatctgc tcgacatagt cgaaatcccg
2787001 cagaatgttt cgtaactccc gccggaaggc gaccctacgt tcggcgaggt cggccgccgg
2787061 cgctatcagc tcctgatcga cggcgacctg gcgtgcagtg gcgaacagca gcgtcgatac
2787121 cggttcgctg ctgcggaccc ggccctgtgc cacaaactga cggccgaggc cgagcgccag
2787181 ctccgtcaac tcctcaggac cgatgtcagg cggagcatcg cgcaacacgt cggcaacgat
2787241 ctcataggct tcgaagaaga cccgcaacat cgcgtccgac atcagcggcc gtttggcata
2787301 cagcatcgcg tcgatctcat tgcccccgac gccaagatga tcctcccagt cttggtgcca
2787361 ggccatctct tgggcgatgt tggcccgaaa cgccgtggaa tccgcgaaat agaagtcgaa
2787421 cttcagcaga tcccgcaacc gcatcgcctg ggcccagaac gcggcgacgc ggtcaccttc
2787481 ggcgtgcttg gcatgggcca gcgcgagctc gacgatcgag gtctccaaaa acgcatggat
2787541 caccgagttc cggtagaacg ccgcggcgtg ctcgtcgtca ggcgctatgt accataccgg
2787601 ctcccggcca ctgtcgaccc gagtgaccgg gtggccgttg gacaacgcgt ccgccgccgc
2787661 acggacgcct tcgcgcgagc gcagtcgcaa tgcgcttgtc gaaaccggcg attgtttgcg
2787721 ttccagatag tccagtgagt cctgcaacgt gtggtgcagc tggtcgagcg tcaacgcggt
2787781 gccgcgggtg gtgagcagca gtgcggacac caaacccgtc gcggtcaccg gcgtcgcctg
2787841 caaaatcctc caggccacct cgaacgacat cttctgcaac gcaagccgtt tcgcggccgg
2787901 atcctgggtc agctcgccgt gcggtgcgcc gaggtactgg cgcatcgaga ccgcttcggg
2787961 gaagcgaacg tagatcttgc cgaagttgcg ttccccctgc gccttgatga agttgtagag
2788021 ccagcgcaaa ccttcgggcg tcttctccgc gccacgcgcg taggcggcgt attcggtgat
2788081 ctcgtgcagc tgatcgaagc aaatcgaaac cccctgcagc aggatgtcgt cactgcggcc
2788141 gtccaggtaa gcatcggcca cgtagctcat caaaccgagc ttgggcggca acatctttcc
2788201 ggtgcgcgac cgggtgcctt cgatggacca gctcaggttg aaccgcttct cgaccacgta
2788261 gcccacgtac tccttgagca cgtacttata cagtgggtcg ttgccgatat tgcgccggat
2788321 gaagatcatc cccgagcgcc gcatgagggg tcccatgaga ccgaacgaca ggttgatgcc
2788381 gccgaacatg tgcaccggcg gtaaccggtt gtcctgcatg gccaccggta ccaccacgcc
2788441 gtcgatgtag gaccggtgcg agaacagcag gaccgccgga tgagcctcca gtgcggcgcg
2788501 catcgccgcg acctgatact cgtcgtagtc gaattccgga tcgaagccgc ggctagccag
2788561 cctgccgagg acggaaacca ggtctaccga cacctggctc catccggtgg agagttcgtc
2788621 gagcatcttc ccggcatctt cgaccgtggc gcccggaatc cggtccaggc cggcacgaaa
2788681 tcgtgcggac gccaacatct ccggcttcac cagccgggga gatttgtatt gcggtccaag
2788741 gatccgatat tcggcgcgcg ccagcgccaa cagcgctcgg cggctgacga actgggcgaa
2788801 atcgcgcttg tgctctgcca ccgtggtatc gcgccactgc tggcgcagtt cggacacctt
2788861 ggccgactcg ccggccacca cccgcgcgcg cctgggatcg gtacgcagga tgcgacgctg
2788921 ctgacgctgg ctgggatggt agggatcccg acccgggagc agtgcggcca ccttgcccgc
2788981 ccggctgcga tcggcgggag gcagccagat cacccgaacc ggcacgatag aacggtcctc
2789041 gccagattgc gggctggatg cgaagccggg ctcgagctgc tcgaccagtg ccgtcagcgc
2789101 cgccggcgga gcgttgcgcg gtggcagctt caatatgtcg aacttcgagt ccggatggcg
2789161 tgcacgctgc tggcccagcc agcccatgat cagctccatc tcgaccggcg tcgccgtgga
2789221 agccagcacc agtgtgtcct cggcagtaag caccgcgctg gcatcggccg ccggtttggt
2789281 cacgaccgtc ctttggcgct agagcttggc gatgcggagg cctcaccatc cttgccagcg
2789341 atcttagatt cgctgggttt ggccttcggc gatgccttct ttgtagccgc cttcgtcgcg
2789401 gccgcgcctt tattggcggc gcttttggcg ggagccttct tagccggcac ccttttcgcg
2789461 gtggccttgg cgacctgagc cctggctttt ctggcggcct tctgctcggc gtacagatcg
2789521 accgcgggca acccatcgac cggccagtcc gccagcgtgt ccagatacag ctggcgcacc
2789581 tcggcgatac gatccggcag ggcgtccagg gtccagtcat cgaccggaat cggcggaaac
2789641 accgcgacgt cgaccgtgcc cggattgatc gtggtggagt tgcgcgaggc gacgatctcc
2789701 gcattgcgga tcacgatcgg cacgatcggg atcttcgcgg ccatggcgat acggaagggc
2789761 cccttcttga atgacccgac ttcggtggta tccaaccggg taccttcggg agcgatcacg
2789821 atcgatagtc cattgcgggc gcgctcctca accgtgtgca gtgtctccac cgcggcgacc
2789881 ggatcatcac ggtcgatgaa cacaccgtcc agcaacttcc ccagcgtgcc catgatcggg
2789941 tcgctcgcca gttccttctt gcccacccca acccagttgt cgcgcaccag cgcaccggca
2790001 atgaccgggt caacctggtt gcggtggttg aagataaaga cggcgggccg ctgggcggtc
2790061 agattctctt ttccgatcac attcaggtgc acgccgctgg tcgccagcag cagctgagag
2790121 aaggtggagg taaagaaatt cacgccgcgg cgccggctac cggtcagcac accgatccct
2790181 accgcgccgg ccgcgaccgg gacgatggtg ctcagaccgg caagtgtccg caactgccgc
2790241 cggatgccca caccgccgcg actgttgaac ttcaagatcg gccagccccg tcgcttggcg
2790301 accgcggcca tctttccttc cggattggtc ggtcgcggat tgcccaccag atacatcagg
2790361 gcgacgtcct cgtcaccgtc ggcatagaag taactgtctt tgagatcgat gtcgtgctcg
2790421 gccgcaaagc gttgcaccgc agtggctttg cccggacacc acaaaattgg cttcagcaca
2790481 cccccggtga gtatcccgtc ctcgttggtc tcgaacttgt tggtgagcat gttgttgatc
2790541 cccagaaaac gtgcgactgg gccaacttgg atggtcagcg ccgacgagct gaggaccacg
2790601 gtgtggccgc gggccacgtg agcccggacc agttcccgca tttccgggta gatccgggac
2790661 tcgatccgct gggcgaatag ccgctcgccg atttcttcca ggtcggtcaa gagccgcccg
2790721 gccagcgccg cggcggcctt tccgataagg tcttcgaact cgattcgccc gagcgtgtga
2790781 ttcaggccgg cctgaaccat accgagcagc tcgcccacgc ccatatcgcg gcgccgcagc
2790841 ctctcctggg tgaggatgac ggccgtgaag ccggcgacca gcgtgccgtc caggtcgaaa
2790901 aacgcaccga ccttcgggcc ggcaggactg gccagaatct cggctaccga accgggtagg
2790961 cgcaaatccg gcgccgactt ccgcgtcgcc cgctcttccc cctgctcgtc agcggcgctc
2791021 atgagcccga caccgatcga ggcactgaac cggctccttg agtatcgaac gacgccggca
2791081 gcacacgcgg tgccggacca ccggccagcg caaggatttc gtcgaaaccc gcctgcaggc
2791141 attgagcgaa caactcgtcg tttcgcaccg acgccctgtc gtagcgcacc gtgacggtgc
2791201 accacccgcc ccgggaaatt agcactacca tcatcgccac accgggcaac ggtccaatac
2791261 cgtactgccg cagtatcttc gcgccggcaa ggtaggtatc ccctgggtag accggaacat
2791321 tgctggcttg cacatcggaa ccgatcaccg aaccggtgat cccctccagc acggccgtcg
2791381 gcaagacact cagcaccggt gcaatggaac cgatgatgtt catcgcgggc tcgtcgcgac
2791441 gctgggtcat ctgcgcccgg atcttcttca tccgagccac cggatcgata gtgcccaccg
2791501 gcgccgccag gttgacaccg gtgaactggt tgccgccggc cgcatcgccc tcggcccgca
2791561 ggttgaccgg caccgccatc ggcagcgtgc tgatcggcac gcccagggcc tcgtggtagc
2791621 ggcgcagcgc gccacacaga cccgcaaggt aggcgtcgtt gatcgacccg ccgccggcct
2791681 ttgcggcctt gtgcaggtcg gcgagccgga tgtcgatggc ctcggtacgg gtggtcaggc
2791741 tgcgccggcg cagtaggggt gagggttcag cagctcggtt cagcacccgg atgcccgacc
2791801 tggcgtagcc caagatcccc gacacggtgg acaccggttc cagaacagcc cgcccggcca
2791861 tcgataccgc cccggacagc gcgtccagga caccgccgac gacagcaatt ggcaggtggt
2791921 tgatgccccg gcgcatcagg tcattggggg acagatcctc cggaatgggt tgcggcggcg
2791981 tcgacctagg tggtggatcg cgctcgaggt catagatctg cgcgaacatc tccacgccgc
2792041 cgacaccgtc ggtgaccgca tggctgacgt gcagcagcat cgccgctctg ccgtcagcca
2792101 taccctccac cagggtggcc gtccacagcg ggcgcgatat gtccagcggc gactgcagaa
2792161 tcacctcggc gagatcgagc acttcgcgca acgtggcggg tccggacaca cgcacccgac
2792221 gcacatggaa gtccagattg aagtccggat ccaccaccca gcgcggggcc gcggtcggca
2792281 aggtcggcac caccaccttc tgccgcagcc gcaacacccg tcgcgaggcg ttttcgaatc
2792341 gggtccggaa gcgatcccag tccggcgtgc cgtccagcag ttccagcgcc atgatccccg
2792401 aacgagtccg cggatttgcc tcgccccgat gcatcaaata gtcgaccggc ccaagctcgt
2792461 cggacaacct gggggactcg ccggactcag ccatggccac gaccccgcgc gggttgggca
2792521 actcgacgca caaactctgt caccgccgat cagacctcct gcttcaaacc cgccaccgcc
2792581 acgcaccaca gtgccaacac aacgctagtc gcgatgacgc ggtggtgaaa gccgatgcgg
2792641 gccatgatcc acccgcagca ccgatgccgc ggccacgacc gacgaaacct cgtgttgggc
2792701 agccgagttg gaacggccaa gctcagctgg ccggaggtga cgacagcgcc agcgaaccct
2792761 tgcgagcacc catccgtcgc ccgtagatca cacccaagaa gtccgagacc gcttcggcga
2792821 ccatccgcga tcggaccgtg gcggcgaggt cgaacgcgtg gtgggcgttg gggagctcag
2792881 cgtaggacac cgtcgcggca cccgcgtcgc gcagcgccgc gctgaaggcg cgagattgcg
2792941 cgctcggcac catcggatcc ttctcaccgt gcaacacgaa gaacggcgga gcctcgctgt
2793001 ggacgtacga aatcggcgac gccgccttga acagccccgg gttgtcgacg tagcggctac
2793061 gcatcacgaa gtgctccagg aacggcatca tcatttcgtg catattctcg gcgttggtga
2793121 ggtcgtagac gccgtagtag ggcgccgcgg cttgtaccgc cgtgtcggcg ctttcgaagc
2793181 ccggctgcag cgccggatca ttcgccgaaa gcgcggccaa cgcggccagg tgcgcaccgg
2793241 cggacccgcc ggtgatcgtg atgaaatccg gatcgccgcc atagtcggcg atgttctcgc
2793301 gaacccacgc aatcgccctc ttcacgtcca caatgtgcgc cggccacgtg caccgtgggc
2793361 tcttgctgta gttgatcgac acacagatcc agccgagttc caccatccgg ctcatcaacg
2793421 ggtaagcctg agggcgtttg ccgttgatgg tccacgcccc gcccgggacc tggatgagga
2793481 ccggagcccg gcggccgggc gctaaatcgg gacgccgcca gatgtcgagt agattctcgc
2793541 ggccgccggg cccgtacggg atgtcggagg tctgggccgc atagcggcga tggggtccgg
2793601 gaatgtgcgg taggttcagc agcccgctgc gccgggcagc ctctgactgt tcgccggtcg
2793661 gatgccacac taggtcacgg aaatccgggc cgaaagcgtc cacgagcgcc gcgtgcagga
2793721 tttgatccgc ccgctgcgcc gcccagctgg tgccaaaccg gccgatcgag cgtggtgata
2793781 tgcgggacag cgcgtggccg gtgacgacgc gggccggaaa ctccgcggac aaccatcctg
2793841 cgacccaacc gatggcgcac ggtgatccac gcagcagcag ggcgccggcc cggcaggtgt
2793901 ctctggcgtc ggccgccagc tgcgctccct ggcgcaatgc ctcggcgccg gcccgcgagc
2793961 accgcgaagt cacgctggcg atgtgcataa caaagcccac ccctcgacgt caggcacacg
2794021 catcgttgcg gtaaacggct ggttgccagc cggttttgta cgtgtgtcga ggatcacaca
2794081 ataaccaata attgacgtgg cggtagacct ttcgcgcgtg tggcgtctgg aaaaattcct
2794141 cgacggccac cgttagataa actgacctgc gcatcgcctc cgtagctcag gtggatagag
2794201 caagggcctt ctaatcccta ggtcgcacgt tcgagtcgtg ccgggggcac tgtggaaata
2794261 gcaggtcagc atggtggcgt ggcttgacac cgcctcgtta tgggtcgacg cccagagtcg
2794321 ccttcaaact caaaccacgg aggtgcccga tggcccaata cgacccggtc ttgctcagcg
2794381 tcgacaagca cgttgcgctc atcacggtca acgacccgga ccgacggaac gccgtcaccg
2794441 acgagatgtc ggcgcagttg cgtgcggcga tccaacgcgc cgaaggcgac cccgacgtac
2794501 acgccgtagt cgtgaccggg gcgggcaagg ccttctgcgc cggggccgac ctgagtgcgc
2794561 tgggcgccgg ggtcggcgat ccagccgagc cgagattgtt acggctctac gacggtttca
2794621 tggccgtcag tagttgtaat ctgcccacca tcgccgcggt caacggcgcg gctgtgggcg
2794681 ccggactcaa tctggcgttg gccgccgatg tgcgcatcgc cggaccggcc gcattgttcg
2794741 acgcccgctt ccaaaagctg ggactgcatc caggtggcgg cgcaacctgg atgctgcagc
2794801 gagcggtggg tccgcaggtc gcccgtgcgg ccttattgtt cggcatgtgc ttcgacgccg
2794861 aatccgctgt gcggcacggc ttggcgctaa tggttgccga cgatcccgtc accgcggcgc
2794921 tggagctggc cgccgggccc gcagccgccc cgcgcgaggt cgtgctggcg agcaaagcca
2794981 ccatgcgcgc cacagccagc cccggatcgc tggaccttga gcaacacgaa ctcgccaaac
2795041 gcttagaact tgggccgcag gcgaaatcgg tccagtcgcc cgagttcgcc gctcgcttgg
2795101 ctgccgctca acacaggtag cgcctaccag cctcgagggt ttccatggcg tgccccagtc
2795161 cgaagctgct gctgcttgac tccgcgcgct gggcccgagc gcgcgctgtt gtacggccca
2795221 aacggcgtgt cggtgtacag tcgcgcgctc gcggcttcag tccggccccc cgactccggc
2795281 aggcccgacg gcgcccagcg ctagccgggc gcgccggcca tgccttcggt gccggaaacg
2795341 ccaggggacc cggggccgtt ggtgaggccc cccgcgcctg cctcaccgcc gctaccgccc
2795401 gcgccaccgg caccgcctgc gccgcccgcg ccaccgatac cgtcagcgcc gctgactcct
2795461 gcggcaccgc tgaggaaccc tccggaccca cccgcaccgc cggcaatacc gccagcgcca
2795521 ccgttaccgc cgtttgcgcc gttgcccccg ttgccgcccg tcccgccggc cccgccgatg
2795581 gagttctcat cgccaaaagt actggcgttg ccaccggagc cgccgttgcc gccgtcaccg
2795641 ccagccccgc cgactccacc ggccccaccg actccgccgc tgccaccgtt gccgccgttg
2795701 ccgatcaaca tgccgctggc gccacccttg ccacccacgc caccggctcc gcccaccccg
2795761 ccgacaccaa gcgagctgcc gccggagcca ccatcaccac ctacgccacc gaccgcccag
2795821 acaccagcga ccgggtcttc gtgaaacgtc gcggtgccac caccgccgcc gttaccgcca
2795881 accccaccgg caacgccggc gccgccatcc ccgccggccc cggcgttgcc gccgttgccg
2795941 ccgttgccga acaacaaccc gccggcgccg ccgttgccgc ccgcgccgcc ggtcccgccg
2796001 gcgccgccga cgccaaggcc gctgccgccc ttgccgccat caccaccctt gccgccgacc
2796061 acatcgggtt ctgcctcggg gtctgggctg tcaaacctcg cgatgccagc gttgccgccg
2796121 cttcccccgg gcccccccgt ggcgccgtca ccaccgatac cacccgcgcc accggcgcca
2796181 ccgttgccgc catcaccgaa tagcaacccg ccggcgccac cattgccgcc agctccccct
2796241 gcgccaccgt cggcgccgga ggcggcactg gcagccccgt taccaccgaa accgccgcta
2796301 ccaccggtag aggtggcagt ggcgatgtgt acgaaagcgc cgcctccggc gccgccgcta
2796361 ccacccccac tgccggcggc tacaccgtcg gacccgttgc caccatcacc gccaaaggcg
2796421 ctcgcaatgt cgccctgcgc gactccgccg tcgccgccgt tgccgccgcc gccaccggca
2796481 gcggcggtac cgccgtcacc accggcaccg ccggtggcct tgcccgagcc tgccgtcgcg
2796541 gtggcaccgt cgccgccggt gccaccggtc ggcgtgccgg cagtgccatg gccgcccgtg
2796601 ccgccgtcgc cgccggtttg atcaccgatg ccggacacat ctgccgggct gtccccggtg
2796661 ctggccgcgg ggccgggcgt gggattgacc ccgtttgccc cggcgaggcc ggcgccgccg
2796721 gtaccaccgg cgccgccatg gccgaacagc ccggcgttgc cgccgttacc gcccgcaccc
2796781 ccgatgcctg cggccacgct ggtgccgccg acaccgccgt tgccgccgtt gccccacaac
2796841 caccccccgt tcccaccggc accgccggcc gcgccggtac caccggcccc gccgttgccg
2796901 ccgttgccga tcaacccggc cgcgcctccg ctgccgccgg tttgaccgaa cccgccagcc
2796961 gcgccgttgc caccgttgcc aaacagcaac ccgccggccg cgccaggctg cccgggtgcc
2797021 gtcccgtcgg cgccgtttcc gatcaacggg cgccccaaaa gcgcctcggt gggcgcattc
2797081 accgcaccca gcagactccg ctcaacagcg gcctcagtgc tggcataccg acccgcggcc
2797141 gcagtcaacg cctgcacaaa ctgctcgtga aacgctgcca cctgtacgct gagcgcctga
2797201 tactgccgag catgggcccc gaacaacccc gcaatcgccg ccgacacttc atcggcagcc
2797261 gcagccacca cttccgtcgt cggcatcgcc gcggccgcat tagccgcgct cacctgcgaa
2797321 ccaatactcg ctaaatccaa agccgcagtt gccagcagct gcggcgtcgc gatcaccaac
2797381 gacacctcgc acctcccgat accccatatc gccgcaccgt gtccccagcg gccacgtgac
2797441 ctttggtcgc tggctggcgg ccctgactat ggccgcgacg gccctcgttc tgattcgccc
2797501 cggcgcgcag cttgctgcgc gagttgaaga cgggaggaca ggccgagctt ggtgtagacg
2797561 tgggtcaagt gggaatgcac ggtccgcggc gagatgaata ggcggacgcc gatctccttg
2797621 ttgctgagtc cctcaccgac cagtagagcc acctcaagct ctgtcggtgt caacgcgccc
2797681 cagccacttg tcgggcgttt ccgtgcaccg cggcctcgtt gcgcgtacgc gatcgcctca
2797741 tcgatcgata acgcagttcc ttcggcccag gcatcgtcga actcgctgtc acccatggat
2797801 tttcgaaggg tggctagcga cgagttacag cccgcctggt agatcccgaa gcggaccgct
2797861 cccatgcgcc cccgggccgc gtcggccgcg ccgaacagcc gcaccgcttc ccggttgctg
2797921 ccggcatccg ccatcaccga ggcgaggcac tcgagaatgt cggggaccca taggtatgcc
2797981 ccaatggacg cggccacgcc gagggcgtcg tgggcatcgc gctcggcccg gtggcgatcc
2798041 ccttgggcga tctcgatgcg gcaacgggta gtcagggcgc gggcgcggtg cacgccacga
2798101 gtgatcgacg ctgcgccgtc ggccaatcgg tgcgccgcgt tcagatcacc tcgcgcacac
2798161 gatatttgag ccgaactggt ggggtcgttg atgatcgccg ccgcgctggc accaaagaat
2798221 cgcgttgccg attcgcgggc gtgttcggcg gccgcgacgt caccggcggc cagggtcgcg
2798281 aagaccagcg cggagcaggc cgagcccgac agcaccgggc tgagtccaac ggcggtgtcg
2798341 atgctggctt gggcggcggc ggccgcctcg gtgtcgccgc ggtgcgctaa cgcgtgcgcc
2798401 aagcaagcct ggcccgcgca gctgctaacc atgtcgtgcg cggcgtcgga ctcgccgatc
2798461 acctcgcgcg acaggccgac cgctgcctcg aggttgccct gccagagatt cgccgcggcc
2798521 agcgcccagc gacatgaacg tgaaaggaat gcatcaccaa tctcgtcggc gaggcttcgt
2798581 gcctcctcgc ccgccgcgcg ggtcgcgccc gggtcaccct cgccggcgaa cccgacatag
2798641 gcctgccagg ccagaacctc ggccaaccgc cacttgtcgc ccaccgcccg ggccaggccg
2798701 acggcctcgg ccagccacgg tcgcgccaga tccgcgttgt aggcggcgac acccccgcac
2798761 gcggtcagcg cccgcgccag cagggccgga tcctcgatgt cgcgcgctat agccagcgcc
2798821 ttctgggcat catctaggcg gtcggtgatg ccggccacgg catctatcag ggcccggtcg
2798881 gccagtgccc gcgcatacaa cccagggtcg gcccccgccg gatgtgcatc gtggtcggcc
2798941 agggcggcgg cgaaccaggc cagcccctct tgcaggcggc cccgggcacg ccacaacggc
2799001 tgcagacatg atgccaacag caacgcgtgg ccggtatcgc cattctcgcg gctgaacgcg
2799061 aaagcggccc gtaggttgtc gatctcgagc tcggcctggt tgagccggcg ttcatggccg
2799121 gccaccgagg gggcgtcaag cccggcggca acggccgcgt agtggtcgcg gtgtcgcgca
2799181 cgcacggcat cggcatcgcc ggattcacgc agcttctcca acgcatactg gcgcaccgtc
2799241 tctagcaggc ggtagcgcgt tcggccgtcg ctgtcgtcgg tcaccaccag agacttgtct
2799301 gccagcaggc tgagcagatc gaccacctcg tagcgctgaa cgtcaccgcc ggcggctgcc
2799361 gcttgggcac cgtcgagatc aaacccgctc gggaaaaccg ccagtcgccg aaacagcacc
2799421 tgctccggtc cggtcagcag cgcatgtgac cagtcgacgg aagcccgcat cgtctgctgg
2799481 cggcgcaccg caatacgcga tccaccggtc agcaggcgga accggtcatg caagctgtcg
2799541 acgatttcgg tcagcgccag ggcacgcacc cgcgacgctg caagttcgat cgccagcgga
2799601 atgccgtcga gtcggtggca gatctcggtc accagggcga ggttgtcggc agtgatctcg
2799661 agttcgggcc gcgcctcacg agcgcggtcg gtgaacaact cgatcgcctc gccgtgcccc
2799721 agcgggggaa cccgccaaat ctgctcaccg gccaccgcga tcggttcccg gctggtcgcc
2799781 aataccctca gcgctgggca cgccccgagc aacgcgacga tcagagccgc gcacccgtcg
2799841 agcaagtgct cgcagttgtc cagcactacc agcatgcgcc ggtcgccgat acgccgcaca
2799901 atggtgtcca ccgtcgagcg gcccggctga tccggcaacc ccaaaacccg cgccgccgcg
2799961 atcggcacca gcgccgggtc ggtgatcggc gccaggttga cataccaaac cccgtccgga
2800021 taaccgtcgg caacggcgct cgcgacctgt gtcgccaggc gtgtctttcc gaccccgccg
2800081 acaccggtaa gggtgaccca ccgtttgacg tccagcagcc cacggacttg cgccacttcg
2800141 tcgacgcgcc ccaccagccg agtgagctgg gccggaagac agtgcgcacc aacgactttc
2800201 cgggtccgca gcggcgggaa cgcgttgtgc agatcagggt gacacagctg caccacccgt
2800261 tccggtcggg gcaggtcgtc cagccggtag gtaccgaggt cgttcagcca cgcgtccttg
2800321 ggcagcaggt cagcaaccag atcgctggta gttcccgaca acacggtctg gcccccgtgg
2800381 gccagctcgc gcagccgggc ggtgcggtcg atggtcggcc ctacgcagtt gccctcgtcg
2800441 ggtgacgaca cctccccggt gtgcatgccg atgcgcagcc ggatcggtgc cagcggcgcc
2800501 cgctgcaagc ccagggcgca cgccacggcg tcggatgcgc gggcgaacgc caccaagaag
2800561 ctgtcgcctt cgccctgttc gaccgggcaa accccgcggt gctcgcgaac caattcggtc
2800621 agcgttcggt ccagtttggc gatcgccgtc gtgtcaagct gagaccccgg caggtgggtc
2800681 gcgccctcga tatcggccag cagcaacgtc accgtgcccg tcggtacaag ctcgctcaca
2800741 ccatctgcgc tccagtccac aggtaccacg tcgacgccgg ggtgaatctt gctcatgcta
2800801 gccagcatcg agccagcgcg tagcgcatta catcggcacc tgcgcctaga ttgctcgaaa
2800861 tctcttggcc gccggtccat gtgttctacg cgctttagtc gatgcattcg gcgaccggcg
2800921 tgccatcgcg gcggacctac agtgcccgtg ctgtccgctg gcaattgtga gtcccccagt
2800981 gctggcagca tcgcccgcaa gaaccgacac gaccgcatcg tgggcggtgc cgtcgaagtc
2801041 gccggctgac cgatcggcgg agtcaccggc ccgatggggt ttccgaaggc tagggaatga
2801101 tgacgatggg gcggccgcct cggccgcctt cgccgtaacc cccaaccatg cggaaaacga
2801161 gcctagcgtc gcccggccgc gcagagcgag ccatcgcggt ggcgccaacg acaggaagcg
2801221 atccggattc tctgaccatg gtgggtgttc tggctacgtg acgttaacgg agatggaggg
2801281 gccgccttcg ccgccttcac cgccggaacc gccggagcca gggtcgcccc tcccgttgcc
2801341 ggagccaccc gactcgcccg acgagccgac gccgccggag gtcaagccac cggcaccgcg
2801401 tccgccgtca cctccgcgcc cgccgtcccc gccgtcaccg ccgccgatgc tgcgaggcgg
2801461 aggggcgccg aagccgccgg agccgccggt cccgccgtcg cctccgtcac caccgggggc
2801521 gccaccgtct cgcccggccc cacccaagcc gccgttgccg ccgttgccac ccggcccgcc
2801581 gtcgcctgca tcagcaaagc tgccgttgcc gtccccaccg tgaccgccgt tcccgccgtc
2801641 gcctccgtca ccgccggggg cgccgaagcc ggccttgccg tgcgcgccac ttgtggaacc
2801701 gaaaccgcct tgtccgccgg ggcggcccca cccgccgtcg ccgccgtcac ctccgtcgcc
2801761 gccaggctct ccgtcaaaat ccgcgagata ggtaaagccg tcaccgccca agccaccatt
2801821 accagcgtcc ccgcccgacc cgccgtcacc gccgtccccg ccaacgcctc gattgccgac
2801881 ctcgccggcg ggtgccgacc cgccggcccc gccgtttccg ccggcgccgc cccacccgcc
2801941 gtagccaccg tcgccgccgt cgccgccgtc gcggcccgtc gtttcgttaa tgtcaaagcc
2802001 gtcaacgccg ttaccgccga ccccaccagc cccgcctagg cctccggccc cgccgtcacc
2802061 accgtcgccg gtctgagttc cgccggcgcc accggccccg ccgtcgcctc ccgccccacc
2802121 gctgccgccg tcgaagccgt cgaagccctt taggtcggag tcgggcgacc aacccgcgcc
2802181 accggccgcg ccgttgcctc cctggccgcc ggttccgccg ccgccgttca tcccggcgtc
2802241 gccgcccgcc ccgccgtgtc caccaacccc gccgccgccg ccggggctgc cgccccggcc
2802301 agccccacct tggccgccgg ctccgccgtt cccgccgtcg cccagaaatg ctccgccggc
2802361 gccaccagcc ccaccggcgc caccagcccc accgttgccg ccagcaacgg tgagccctcc
2802421 gagggcaccg tgcgcgccgt cgccaccctt gccgccgtca ccgccgtcac cgatgtcgcc
2802481 ggcgtcaccg cccttgcctc cagccccacc ggccccgcca tcaccgccga gagcttcggc
2802541 agcggtgccg tcggccccat caccaccggc tccgccgtcc ccgaatagcc cggcgttgcc
2802601 gccgtcaccg ccctggccgc cgtcgccgcc ggccgcggcg gccttggcac cgttgccgcc
2802661 gacgccgccg tcgccgccgg tcagtggccc gtgtttgctg gcgtccacgc cgttggccgc
2802721 ggaggtgccg ttgccgctgt caccccccag accgccgcga ccgcctgcgc cggggtcacc
2802781 gccgttaccg cccgctccgc cggcgccgcc gacggtgata ccaatgccgc cgttgccgcc
2802841 ggccccgcca acgccgccgg cgccgccgag tccgccgtcg ccaccgaccc caccggtgcc
2802901 gtgactgccg accgtccccg aaggtgcggc cccgccgacc ccaccgtccc cgccatgtcc
2802961 accgaccccg ccggcaccgc catcgccgcc accaccgccg gccccaccgg tgccgccgat
2803021 actgtcgata ccgttggcgc ccctggcccc ggccccaccg ctagcgccca caccgccgtt
2803081 gccgccggcc ccgccgttgc cgccggcacc gccgtcaccc gacaccgacc caccggcgcc
2803141 accggcacca ccggcaccac cggcaccgcc ggcctgcccc gcgtcgccct gacccccgtt
2803201 gcctcccggt tggccgaggg cgagggcatc tgaaccaggc gcgcccgaat tggccccgtt
2803261 ggcgccggcc gcgccatcgc caccattgcc gccggcgcca ccatcgccga cccggccggc
2803321 attgccgccg tcgcctccgt tgcccccggc gccgcccgcg acgctggctt gcgcaccgtt
2803381 gccaccgtta ccaccgttgc cgccgctgcc gggcccgtgg tcgctggcgt ccacaccgct
2803441 ggccgcgcgg gtgccgttgc cgctgtcgcc gcccaagccg ccgaggcctc ccgcgccggg
2803501 gtcaccgccg tcaccgccgt ccccgccatc actgccatga ccgccgtcac cgccgttgcc
2803561 gccggctccg ccgagcccgc cgtcaccgcc aacgccgccg acaccgtggc tgccgacctg
2803621 acccgcgggt gcggccccgc cggcgccgcc atcaccgccg ggcccgccgt caccgccaac
2803681 gccgccgaca ccgccgtcgc cgcctttccc gccggcgcct ccaacggcct cagcgctgtc
2803741 ggcgccggag gcgcccttgc cgccgccgcc accactagct ccggcaccac ccgcaccgcc
2803801 ggccccgccc ttgccaccgg gtccaccgtc gcccgacacc gacccaccgg cgccaccggc
2803861 tccgccggca ccgcccgcgc cgccggcctg ccccgcatcg cctcgaccgc cgttgccgcc
2803921 actacctaac gccgaactcc cggcaccacc gtcaccgccg gcaccgcccg cgccgccacc
2803981 gccaacgccg ccttgaccgc cgttggcctc gcttccttcg cccggttgcc ccgagagggt
2804041 gccgtcggcg ccgtcctcac ctacgttcgc gccattcgca ccggccgcgc cgctaccacc
2804101 gtcgccgccg gccccgccgt caccgaccaa cccgccgtta ccaccggcac cgcccttgcc
2804161 gccgttcgcg ccagccacgg tggcgtcggc gccgttaccg cccttgccgc cgttgccacc
2804221 actgtgcacg gtagcgccgg tcgcgccggt cacaccctcg gtggcgccgg cgccgccggc
2804281 gccacccttc ccaccggcgc ctgggtcacc accatcgccg ccggccccac cgtcaccatc
2804341 cttgaaagcc atgtcgccgc ggccaccgct gcccccgtta ccgggcgccc caccagcccc
2804401 gccggcacca ccgtccccgc caacaccctg gctgcccgcc cgacccgcag gtgcgtcacc
2804461 gccagcccca ccggccccac cgtcaccgcc gcgaccgccg gctccgccat caccaccgtt
2804521 gccgccgtca gatacgagca cagcattgaa accgtgagct ccgttaccac cggccccgcc
2804581 ggccccaccg ttgccgccgg caccgccggc cccgccatcg ccggcgtggg ccccacccgc
2804641 gccgccggcc ccaccggccc cgccgttacc tccatcctca ccgggggtac cggatgaacc
2804701 caggaagatc gccgtcatat cggcatagcc ggcacccgcg gctccgtcac cgccatgacc
2804761 gccggcccca ccgtcaccga ccaacccgcc gttgccaccg gcaccgccgt taccgccatg
2804821 accgccggcg accggtgcgt gggcgccatt gccacctttg ccgccgttgc cgccgctgac
2804881 cggcccgtcg ttgccggccg ccagaccatt ggcccccgcg cgagcaccgg cgccgcccga
2804941 cgcccccccg gctccgccag ccccacccag gcccgggtcg ccaccgtgac cgccggcccc
2805001 gccgtcaccg gcggccagcc aactgccacc gttgccgccg gcaccgccgt caccaggcgc
2805061 tccacccagc cccccacccc cgccagcccc gccgtctccg gcccggccga cataccccaa
2805121 tagtccagcc gacccgccag cacccccggc gccgcccacg ccgccgtttc cgccggcacc
2805181 gccattgccg ccggcgccgc cgtcaccgcc ggccgccgag ataccggccg gcccatttat
2805241 tccggtagcc ccggcaccgc cggcaccgcc ggccgcaccg gcaccaccgg ccccgccgac
2805301 accgccaacg ccaccggcgc cgccgttacc gagaagccac cctccccgac caccgttgcc
2805361 gcccacccca ccggcaccgc catcgccccc gtccgaccct gccaaaccgt caccgccggc
2805421 accgtcgtcc gacccggcaa caccagccgc cccatcctga ccgggcgtag caccgttggc
2805481 cccggccgca cctacaccac ccacgccgcc agcgccccca tgaccaaacc accccgcgtt
2805541 accgcccgcg ccgccggcgc caccaccagc cccaccggca ccaccggcgc cgccgttgcc
2805601 gaacaggccc gcgttgccac ccgccccgcc ggcgccacca ccagccccac ccataccgcc
2805661 gacgccgccc ccacccgcca gccatccacc cgtcccgccg gtacctccgg gtgcgcccgc
2805721 cccgcccgcg ccaccggcgc cgccgatccc aaataacccg gccgccccgc cggcgccgcc
2805781 cacctgcccg acggcaccgg cagcgccgtt gccgccattg ccgaacaaca atccaccggc
2805841 cccaccgggc tgcccaggcg ctgtcccgtg cgcaccatcg ccgatcagcg ggcgtcccag
2805901 tagcgtctgg gtgggcgcat tcacggctcc gagcacgact cgcatcgccg cggcgttggc
2805961 gatctcggtg gccgtgtacc acctcgcggc cgcggtcagc gtgtgcacga actggtcgtg
2806021 aaacgccgcg gcctgcgcac ttagcgcctg atactcctga gcgtgcgcgc tgaacaacgc
2806081 cgcgatgccc gccgacacct cgtcggcgcc ggcggccacc acttccgtcg tcggcatcgc
2806141 cgcgaccgca ctagccgcgc tcacctgcga accaatacgc gccagatcaa aagccgcagt
2806201 tgccatcatc tccggcgtcg cgatcacata tgacatctcg cacctaccca atagcccgac
2806261 cgtcgccgcg ccgctcccgc tgcgactagt gaccccttgg tctcttgagc cagcgacccc
2806321 aactaccgcc gcgacaggcc ttgttctgat ttgccgcgac gacctcccag gtgggtcgaa
2806381 cccactctgt cggccagcag caatgccacc gaacccgccg ccaccggatt gcccacgtcg
2806441 tctttgctga ctttgctgca gtccagaggt gccacgtcgg cacccgggtc aatctcgcgc
2806501 atgccagcca gcatcgagcc agcgggcacc gcaatacatc agcacgtgtg actagattgc
2806561 tccgaattct gtcgaacgcg ggtccgcgtg atctgcgcgt ttcggtcgat gctttcggca
2806621 gcccggcctc cgatcattaa cgaacccgag acgaggagag cgccatggtc gacacgagcg
2806681 cgcccgccag ccggctggac accgatccgc gccgcgctca tgtgagtctt agtaagcacc
2806741 cctaccagat tggagttttc gggtccggaa caattggtcc gagagtctac gaactggcct
2806801 atcaagtcgg tgccgagatc gcaaagcaag gccacattct catcagtggc gggatgactg
2806861 gcacaatgga agcctcctca cggggtgcgt cggacgccga cggccttgtc gtcggcgtcc
2806921 tgccgggcga caagtttacc gatggcaatg cctattccac gataaagatt ctgagcggta
2806981 tgcagtttgc tcgtaactac ataacaggtt tgagctgcca cggagcaatt gtcgtcggcg
2807041 gctcgagcgg cgcctatgaa gaagcccgtc gtgtctggga aggccgtggc cccgtggtgg
2807101 ttctagcgaa cagcggatcg ccaacgggtg cgtctgcgca aatgctgtcc atgcaggaaa
2807161 tctttggggt cgcctttccg gaggacaaac ccaagccctg gcgagtcttt tcggcggcaa
2807221 cccccgccga atcggtgtcg cttgtcattg gcctgatccg gaaaggatat gcccaacatg
2807281 agccgtagga taattaacga gttcggagta cagatctacg gggccacgat aggtgacacc
2807341 tgggccgggc tggtcagggc ggtgcttgac cttgggtctc agtgttttga cgaagaccga
2807401 gagcgtatag cgctgtccaa cgtccgcatc aagtcttcgg tgcagaatta tcccgatctc
2807461 actattgaag aacattgcaa cagcgcccaa ctaaaggcca tgctagattt catgttcaac
2807521 accgatacca tggaggatat cgatgtggtc aagagcttca gtcgtggcgc aaaaagctac
2807581 catcgccgga taaaagaagg acgaatgatt gagttcgtaa ttgagcgact gagtctaatt
2807641 ccggaaagca agaaagcagt ggtcgtgttc ccgacttacg aggattacgc ggcggtcatg
2807701 cgtaatcatc gagacgatta cttgccttgc cttgtttcga tacagttccg cttgttgcca
2807761 gacggcaaag attacgtctt ccacacgacg ttctattcgc ggtccatgga cgcctggcaa
2807821 aaaggtcacg gcaatctttt gtctatcgcc aagctatcgg attgggtgcg agagaacgtc
2807881 agtgcgcgca ttgggcgcaa gatcatgctt ggcccgcttg atggcatgat ttgtgatgtt
2807941 catatctaca aggagacgta tgcagaggct tgcaagcgtt tggccaacct cgaccttagg
2808001 cgaacacaat ttgacgcggt gcggaattag tgaggacgct aagcctcccc agctgatgcg
2808061 ttgatgcgct agcatcaggg ctgtgcgaac gacacttgac cttgacgacg atgtgatcgc
2808121 cgcggcacgt gaacttgcct ccagccagcg ccgctcgctc ggctcggtga tttccgaact
2808181 cgcacgccgt ggtctcatgc ccggacgcgt cgaggctgac gacgggctgc cggtgatccg
2808241 cgttccagcc gggaccccgc cgatcacacc ggagatggtc cgtcgcgcgc tcgatgagga
2808301 ctgacgcggg tggcgctgct cgacgtcaac gcattggtcg cgctggcgtg ggactcacac
2808361 atccaccacg cccggatccg cgagtggttt accgccaacg ccacgctcgg ctgggcgact
2808421 tgcccgctca ccgaagccgg cttcgtgcgg gtgtcgacga acccaaaagt acttcccagc
2808481 gcgatcggga tcgcagacgc tcgacgggtc ctcgtggcac tacgcgccgt gggaggccac
2808541 cgcttcctgg ctgacgacgt atcgctcgtc gatgacgatg ttccgttgat cgtcggttat
2808601 cgccaggtga ccgacgccca tctgctgaca ctcgcccgcc ggcgcggcgt ccgcctggtc
2808661 accttcgacg ccggtgtctt caccctcgcc caacaacgcc ccaagacgcc agtggagctg
2808721 ctgaccatcc tctaaccaaa gctgccagcc cgcccggcta cagatccaac agcgcggtct
2808781 ccggcgactc gatcagatcc cgcagctcac acatgaactg ggccacctga gcaccatcga
2808841 caacgcggtg gtcgaacaca caagtcaacg tcatcgtcgg ccgtgcgaca acctcgccgc
2808901 cgacgaccac cgggcgcggc ttgatcgccc ccagacccag gatcgccgct tcgggatggt
2808961 tgatcaccgg cacgccgtcg tcgactccca gcgccccgaa gttcgacacc gtgaacgtcg
2809021 aaccgcgcag ctccgcgggt gtgagagtgc cttcacgtgc gccggtgatt aattccgcta
2809081 cgcgggaggc aagttcgcgg gtgttcttgt cctgggcgtc ggtcaccacc ggcaccagca
2809141 atccacgctc agtggccgcg ccgaacccca gatgcacacc gcgatgcacg tgtacttgcg
2809201 ggccttcgcc cgagtcgacc cacgtcgagt tgagaattac gttgtgtttc aatgcaataa
2809261 ccagcagccg cagcgtcagc gcgaacggtg taatctcggg cgccgccgaa acgaaccggt
2809321 cgcgcagccg cagcagttcg gcgcaaatta cctcaacgct ggcctttgcg gtcggaatct
2809381 ccttgtggga caacgtcatt ttttcggcca tccgcgcgtg cacgccgtgg accggccgca
2809441 cgtccggccc ggctccgacg ccgcctcgag cagcggccag cacatcggcc cgggtgatca
2809501 caccgccggc gcccgaccca cgctgcaatg cggccaggtc gaccgccaac tctttggcca
2809561 gcttgcgcac taccggtgcc gccagcggcc ggcttgtccg tctactggtt tcgatcgcgg
2809621 tgtcggcacc gtagccgacc aacgtgggga ccgctccttc accgttaggc tgcgcaactg
2809681 ccgtgggccc ggtgtcgatc cgaactagct ccgcgcccac tttgagcaca tcgccttcgg
2809741 cgccgcctaa ctcgacgatc cggccggcat acgggctggg gatttcgacc tcggccttgg
2809801 cggtctccac cgaacacagc gtctggttga tctccacatc gtcgccgacg gcgacgctcc
2809861 aacacgtcac cgtcacttcc tgcagtccct cgccgaggtc gggcaccggg aaagacctga
2809921 tgctgtcctc accgctcatg gctgacgcag cacacgttcg acgcagtcca acagccggtc
2809981 ggggccgggt aaccacaatt tttccaaccg cgcaggcggg tagggtgtgt caaaaccgca
2810041 ggcacgcaac accggagcct ccaattggta gaacatctct tcctggatgc gcgcggccag
2810101 accggcacca tagccgaggc tgcgcggccc ttcgtgcatc accacgcaac gcccggtgcg
2810161 ctggatcgac gcagcaatgg tgtcgaagtc cagcggcgcc aacgaccgca gatcgataac
2810221 ctccagactc caatcatgtt gctgctctgc agtatccgcg ctagacaggg cggtgctcac
2810281 caggtttccg tacgttacca cggtcacatc ggtgccggac cggcgcacca tcgcgtgccc
2810341 gatcggcggt tccggccggc tagtgtcgac catcccgcgg ccgtggtagc ggcgtttggg
2810401 ctccagatac atcacggggt ccgggcaggc gatagcgtgc cgcagcagcc agtaagcgtc
2810461 accgggtgtc gacggcacca ccaccttgag gcccgcggtg tgcacccagt aggactccgt
2810521 ggagtccgaa tgatgttcgg ccgcaccgat accgccaaac gaggggatcc ggacggtcac
2810581 cggcatgtcc acctcaccgc gggtgcgagt ccggtacttg gccagatggc tcaccacttg
2810641 gtcgaaagcc ggataggaaa agccgtcgaa ctggatttct ggcaccggca caaagccacg
2810701 tagtgccaac ccgacggcta ttccgatgat cgcggactcc gccagtggcg tgtcgaagca
2810761 ccggtctgca ccgaacgtat cggccagtcc ctcggtcacc cgaaacaccc caccctcgac
2810821 cgcgacatcc tcgccaaaca ccaatacccg ctcgtcggcg gccatcgcgt cgtacagggc
2810881 gcggttgatc gcctggacca tggtcaacga ctgcgtgatg tcgctcaccg ctaccgcaag
2810941 cgtctcatcc ggcctggccg gacggtctgc gatttgagtc atgcccgcct cctcagtcag
2811001 tccgcgccag ttcggcacgc agctgttcgc gctgcgcctg caacccgggt gtgatttcgg
2811061 cgtacaccgt ggtgaacacc tcatcgacgt cgaagtcagg cgcatcaaag accgcgtcgc
2811121 gtagctcgga ccgcacgtgt tttgcccgag ccgtcacctg ttcctcgagg cgttgcgacc
2811181 acaggccctg atcttgtaag taagtgcgat agcgcggaat cgggtccagc gtcgcccagc
2811241 ggtccacctc ctcctggctg cggtaccggg ttggatcatc ggcggtggtg tgcggaccaa
2811301 gacggtaagt gaccgcctcg atcagcgttg gaccgtcgcc ggcccgagcc cgagcggcag
2811361 cttcggccat caccgcatag catgccagca cgtcgttgcc gtccacccgg atgcctggca
2811421 tcccgtagcc aatcgccttg tgcgcgatag atggtgcggc ggtctgcctg gataccggca
2811481 tcgagattgc ccactggttg ttctgcacgt agaacacgca cggtgtggtg aacaccgccg
2811541 cgaaattgag cgcctcatgt acgtcgccct cgctggtggc gccgtcgccc agaaaggcca
2811601 ccgtcacgga gtcctcgtcc aggcgttgcg cggccatcgc cgcgcccacc gcgtgcaagg
2811661 tctgggtgcc gatgggaacc gacatcggtg cacagcactt cgtggtgaat tgcagcccgc
2811721 cgtgccaggt tccacgccac gcgaccccaa catgtccagg cgggatgcca cgcactaggt
2811781 agacgcccaa ttctcggtat tgggggaaca accagtcggt tttgcgtagg caagccgccg
2811841 cacccacctg cgcggcttcc tgcccgcgac agggcgtgta caacgccagc tccccctggc
2811901 gctgcagatt gacgaattcg gtatccagct cgcgggtgac caccatcatc tcgtagagcc
2811961 aacgcagcgt ttcctcagga aggtcacggt ggtagcggcg ttcggccgtc ggcgtaccgt
2812021 ccgggccgac gagttgcacc ggctcaagat cgacagacat caacatccca gatggcctcc
2812081 gagaaccctc ccccataccg tctcctcagc tcgcgatcac aacgcggtta cgcgtcagaa
2812141 gatgccgtgc gttccatcct tagcgtcggc gctggtggtg cggcgctcac agcacatccc
2812201 gcctgggaaa ccgctgcgag ccgaagttga tcgccggccg caccaaagct tccgctcgcc
2812261 gcaacactgg cgcttcctcc attatgcccc caaatgtgaa gagtccggac cgatcgcgaa
2812321 cgcatcgcaa ccgtgtcgcg ggggatctgc gccctcattc ggaggtggct tccccggctc
2812381 gccgcaacat cgtttccgcg tgcgtgagca ctggagagtc gaccatctgg ccttcgaacg
2812441 cgaacgcccc acgctcgctt cgcgacgcgg ccaaaacccg ccgagcccag gccagcttct
2812501 cgtggctggg tcgataggcc ttgcgcacca ccgggatctg actcgggtga atgcacacgg
2812561 tcacgtcaaa gcccaccgcc gcggcgtctc tggcctcttc ctgcaagccc tcgacatcga
2812621 ggatatccag atgtacggca tcgagcgcga gacggccgaa cgcggacgcg gcgagcagga
2812681 tggtcgagcg gacatgtcgg gccacgtcac gataggcacc gtcggcccgc cggctcgagc
2812741 taccgccaag ggtggcgatc aagtcttcgg caccccacat cattcccacg gtgggatcgg
2812801 ccgcggcgat ttcggcggcg cacacggcac cgcgcgcggt ctccaccagc gcgatgacat
2812861 cacgcggcgc aagctcgatg acttgggccg ccgattcggc cttgggcagc atcaccgtgg
2812921 tataggcggt gcctgcgagg gcctccagat cgcgggcctg atcagcagta ccgcccgcat
2812981 tgatacgcac caccgtgcgt tccgggtcca gcggggtgtc ccgcaacgca ttgcgcgcgg
2813041 caggcttctg cgcctcggcc acgccgtcct cgaggtcgag aatcaccacg tcggccgcgg
2813101 cggcagcctt cgcaaagcgt tccggacgat cggcagggca gaacagccac cccggaccgg
2813161 cggcacgcag gttcattgcg cctccttaat ggactgcttt tggaccagcg tcgtgcgcac
2813221 cgcgcgggcc accacctcac cgtgctggtt gcgggcgatg tgctcgagtg tgacgatgcc
2813281 ctcgccgggc cggcttttcg actcacgttt accggtacag acggtctctg cataaagcgt
2813341 gtcgccgtgg aagaccggtt tgggaaacga cacctcggag aagccgaggt tggccacgat
2813401 ggtgcccaac gtcaactgcg caaccgacag accgaccatc gtcgagagag tgaacatcga
2813461 gttcaccagc cgctcgcccc gaaaacccgg ctgctgccca gcccacgccg cgtcgaggtg
2813521 cagtgactgg gtgttcatcg tcagcgtggt gaacaacacg ttgtcggcct cggtgaccgt
2813581 gcggccgggc cggtgcaggt atgtggtgcc gatctggaac tcttcaaacc acaagcctcg
2813641 ttgaagaatc cttctgccga ctgtggatcc tgcgacgcga cacgccgata cggcgtcgtc
2813701 agattcacgg tcgccggcgt gctttgtcac tgcagtccca acgatcgcgc gataagcatc
2813761 agctgcactt ccgtggtgcc ctcaccaatc tcgagcacct tgctgtcgcg gtaatgacgc
2813821 gccaccggat attcgttcat aaagccgtat ccgccgtgta tctgggtggc atcgcgggag
2813881 ttgtccatcg ccgcctccga ggagatcatc ttcgcgatcg ccgcctcctt cttgaagggc
2813941 ttgcccgcca acatctttgc ggcggcatca tagtacgctg tgcgggcaac atgggcgcgt
2814001 gcctccatcc gcgcgatctt gaagccgatc gcctgataag cgccgatcgg ctggccaaac
2814061 gactgacgct ggttggcgta cttgacgctc tcgtcaacac agccctgcgc cgcgccggtg
2814121 gccagcgctg caatcgcaat ccggccctcg tccaggatgg acaagaagtt ggcatagccg
2814181 ctcccccggg ctcccagcag gttctccctc gggacccgcg catcggcaaa tgtcagtggg
2814241 tgggtgtccg aggcgttcca gccgaccttg ttatagaccg gttccacggt gaatcccggt
2814301 gtgccgctgg gcacgatgat cgtcgaaatc tctttcttgg catccgcagc ggttccggtg
2814361 gtcccggtaa ccgcagtgac ggtgaccagc gatgtgatgt cggtgcccga gttggtgata
2814421 aattgcttgg agccgttgat gatccactcg tcaccttcga gacgcgccgt ggtgcgggtg
2814481 ctgcccgcgt ccgatcccgc tcccggctcg gtgagaccaa aaccggcgag cgcacggcca
2814541 gacgtcaagt cgggcaacca cttctgtttc tgctcctcgg taccgaaccg gtagatcggc
2814601 atcgcaccca ggcccaccgc ggcctccagc gtgatcgcta ccgattggtc aaccttgccc
2814661 agctcctcaa gtaccagcga cagcgcgaag tagtcgccgc ccatgccgcc gtactcctcc
2814721 ggaaacggca gcccgaacag gcccatctct cccatcttgg cgacaatttc gtatgggaag
2814781 ctgtgttccg catcgtgttt ggccgatacc ggcgcgacca cggtgcgcgc aaaatcggcc
2814841 accgtatccc gaagatcttg gtattccttg ggtaatatcc ccccagaaat cgttgtagtc
2814901 gttgtggtca tgatcctagt ccttgatcct cgccagtacc tgttcgactt tcacctgatc
2814961 gccaacggac accaacacct gtacccgtcc cgaaaccggc gcctccagcg agtgctccat
2815021 cttcatcgct tccaccacca ccaccacatc acccgcagag atctgggagc cggactcgac
2815081 ctgcacggcg atcacgctgc caggcatagg gctgacgacc tccgccggcc gcgcacccac
2815141 ggcgcggtga atcttgtgct cctcggcctc gcgcaggtgc caagtcccgc gctcgtcggc
2815201 gatccacagg tgccggtcag cctctgccca ccgataatcc cggcgcagcc cgcttatcgt
2815261 cacgctcatc tgttctcggg tgacctgcac gctcgcacaa tcgatctcac catcgccaac
2815321 ctgaacctgc gccgactcgg gtggccccca caccgaaacg gtctcgctgc gcagcggggt
2815381 gcgcatggcg gtgcggaccg gtgccatatg gcccccgccg cgccatccgg acggcgcggc
2815441 ccacaggtcg ccctgtgcgc gccgggccag ggcccactgg cggtagaggc cgccggcagc
2815501 tagcacgtcg tcaggcgccg gccgcgcagt gaaatcggcc gatcgctcgt ccagtacagc
2815561 ggtgtccaaa tccccgaccc gcacccgctc gtcggcgagc agaaagcgaa ggaactcgac
2815621 attggtctgc actcccagca ccgcagtccg cgccagcgcc tggtccagcc gatccagcgc
2815681 ttcctcgcga tcggccccgt gcgcaatcac cttggtgagc aacgggtcgt aatcactgcc
2815741 gaccaccgtg ccgcctagca gtgacgaatc cacccgcacc ccggggccgg cgggttcgaa
2815801 caccgccagc acccggccgc cggtgggcag gaattcccgc gcgggatcct ccgcatacac
2815861 ccgagcctcg atcgcgtgcc cacgcagctc gatgtcgttt tgggcgaagc ccaacttttc
2815921 gcccgcaccc acccgcaact gccactcgac caggtccaat ccagtaatcg cctcggtgac
2815981 cgggtgttcc acctgcagcc gggtattcat ctccatgaaa aagaactcgt cggggcgctg
2816041 cgcggagacg atgaactcca ccgtgccggc gccgacgtag tccacgcagc gggcggtgtt
2816101 gcaggccgcg accccgatgc gctcgcgggt ctgcgggtca agcagtggcg acggcgcctc
2816161 ctcgataacc ttctggtggc gccgctggag gctgcactca cgctcaccca gatgcaccac
2816221 gttgccgtga gcgtcggcaa gcacctgcac ttcgatgtgc ctgggccgca acacaaaccg
2816281 ctccaggaat agcgtatcgt ccccgaacga agacatggct tcgcgccggg cactcaccag
2816341 cgcctcaggc agccgcgccg gatcttgcac taaccgcatc cctttgccgc cgccgccggc
2816401 cgacggtttg atcagcaccg gatagcccac ctcagcggca gcggtgacca gcgcgtcgtc
2816461 cgtcagcccg gcgcgcgcca caccgggcac caccggaaca tcgaaagcgg cgaccgcgtt
2816521 cttggcggcg atcttgtcgc ccatcacctc gatcgcgcgc gccggcggac ccaggaacac
2816581 cacccgggcg cgttcacacg ccgcagcgaa atcggcattc tcggcaagaa acccgtagcc
2816641 cggatggatc gcctgggctc cggtgcgcgc cgcagcatcg agcaccttgc cgatatcgag
2816701 gtagctttcg cgtgctgggg cgggccccag ccgcaccgca gcgtccgcct ccaagacgtg
2816761 gcgggcatcg acgtcggggt cgctgtagac cgcgaccgac cggatgccta gccggcgcag
2816821 cgtccgaatc acccgaaccg cgatctcacc gcggttggcc actagtacgg tgtcaaacat
2816881 cgcctcacat ccggaagacg ccgtagccaa cctgatccag cggagcgtgg gcacacaacg
2816941 aaagggcaag cccaacaacc gttctggtgt ccgcagggtc tatgataccg tcatcccaca
2817001 gccgggcagt tgaatagtag gggttaccct ggtcttcgta ctgcgctcgg atgggcgcct
2817061 tgaacgcttc ctcctcgtcg ggtgaccagg gtgtgccggc cgcggacagc tgctcgccgc
2817121 gcacggtcgc caacacggac gcggcctgct caccgcccat caccgagatc cgcgcgttcg
2817181 gccacatcca caggaaccgg ggcgagtacg cgcgtccgca catcgaatag ttacccgcac
2817241 cataggatcc gccgatcacc acggtcaact tgggcacccg cgcgcaggcc accgcggtga
2817301 ccatcttggc gccatgcttg gcgattccgc cggcctcgta gtcgcggccg accatgaagc
2817361 cggcgatgtt ctgcaggaac agcagcggaa tcttgcgttt gtcgcacagc tcgatgaaat
2817421 gcgctccctt gagcgcggat tcgctgaaca acacgccgtt gttggcgacg atcccgaccg
2817481 ggtggccgtg gacgcgtgca aacgcagtca ccagagtctt gccgtattta gccttgaact
2817541 cgctgaattc gctgccgtca acaatccgca cgacgacctc atgaacgtcg taagggaccc
2817601 ggggatccgg gggcaccaca tcgtagagct cggcctgcgg gtacttgggc tcgaccgaac
2817661 ggcgcacatc ccattgggcg ggttcgcacg ggccgaaggt gtccgcgatc gcgcgcacga
2817721 tccgcagcgc gtcctcgtcg tcgtcagcca gatggtcggt gacaccggac gtgcgcgagt
2817781 gcaagtcgcc accgccaagt tcctcggccg agacgatctc gccggtggcc gccttcacca
2817841 gtggcggacc gccgaggaag atcgtgccct gctcacggac gatgacggcc tcgtcactca
2817901 tcgccggcac ataagcgcca cccgccgtgc aggagccgag aaccgccgcc acctgcggaa
2817961 tgcccttggc gctcatcgtc gcctggttgt agaagatccg cccgaaatgc tcgcggtcgg
2818021 gaaacacctc gtcttggcgg ggcaggaagg cgccgccgga gtcgaccaga tagatgcacg
2818081 gcagcatatt ctgcagcgcg acctcctggg cgcgcaggtg cttcttgacc gtcatcgggt
2818141 agtaggtacc gcccttgacc gtcgcgtcgt tggcgacgat cacgcactgg cgtccggata
2818201 cccggccgat cccggtgatg attcccgcgc ccggggattc gtcgccgtac atgccgccag
2818261 cggccagcgg agccagctcg aggaaagggc tgcccgggtc gagcaggcgg tccacccgtt
2818321 cgcggggcaa cagcttgccg cggctgacgt ggcgtttccg ggcgcgttcg ttgccgccca
2818381 gggcggcggc ggcgagctta ttgttcaatt ccgccaccag ccggcggtgc tcgtcggcga
2818441 acgagggggc tattgctatc gacggggtgg tcactgggtc gccaggtccc gaagcacaag
2818501 gggcggttga gtcttcgcga ctacctcgtc gaccgacacg ccaggagcgg tctggaccag
2818561 gtgcaggccg tcagcgcaga catcgatgac cgcgagttca gtgacaatgc ggtcgacgca
2818621 gcccacaccg gtcaacggca atgtgcaccg ctctaggatc ttggggctac cgtccttggc
2818681 ggtgtgctcc atcatcacga tcaccttgcg agcgccgtgt accagatcca tcgcgccgcc
2818741 catgcccttg accatcttgc cggggatcat ccagttggct aggtcaccgg tgaccgaaac
2818801 ctgcatcgcg ccaagcactg cgacatcaag gtggccaccg cggatgattc cgaacgaagt
2818861 cgacgagctg aagaatgcgg cacccggcag cgtggtgacc gtctccttgc ccgcgttgat
2818921 caaatcggca tccacgtcct cccgccgcgg gtaggggccg acgccgagga tgccgttctc
2818981 cgagtgcagg acgacatgga cgccgtcggg aatgtggttg ggaatcaggg tgggcatgcc
2819041 gatgccaagg ttgacatact gaccgtcttc gaactccgcg gccacccgtg cggccatctc
2819101 gtctcggctc cagcccgggg cgctcattgc cgcaccgtct ccctctcgat cttcttggcg
2819161 gggttgggca catgaaccac ccggtgcaca aacacgcccg gggtgtgtac ggtggcaggg
2819221 tcgatctcac ccggctcgac caagtgctcg acctcggcga tcgtgatcct gcctgcggat
2819281 gcgcactccg ggttgaagtt ggccgcggcg tggcggtaca tcaggttgcc gtgccggtcc
2819341 ccctgccagg catgcaccag tgcgaagtcg gtccggatcc cccgctcgag gacataggtg
2819401 acaccatcga actcccgagt ctccttggcc ggcgacacca ccgccacccc gcccgaggcg
2819461 tcgtagcgcc acggcaaccc gccgtcggcg acctgggtac cgacccctgc cggtgtatag
2819521 aaggccggta tgcccatccc tccggcccgc aaccgctcgg ccagcgtgcc ctgcggggtc
2819581 agttccacct cgagctcgcc cgcgaggaac tggcgggcga actccttgtt ctcccccacg
2819641 taggaggaga ctgtccggcg aattcgcttg tgttgcaaca atagtcccag accaacaccg
2819701 tcgattccgc agttgttcga gactgtttcc aggtcggtga caccgctatc caccaacgct
2819761 gcgatcagtg cttcggggat gccgcaaagc ccgaatccac caaccgcaag cgacgacccg
2819821 ttggctatgt ctgcgaccgc ctccgcggcg gtggccacca ccttgtccat accgcagagc
2819881 ctcctagcat ttcagttaat tatcattaac tgaggtgaga ataccattgc ccccgcggtg
2819941 cgtctaggga cctcactgtt ggccgcggag gtattcgagc gcctgttgtc gcatctccac
2820001 tttgcgtact ttgccggtga cggtcatcgg gaactcgtcg acgatccaca ggtaccgcgg
2820061 gatcttgaat cgcgcgatgc ggcccatgca gtactcgcgc agccgctcga tggtcagttc
2820121 cggcgcgtcg tttctcagct tgaccaccgc catgagctct tcgccgtatt tggcgtcggg
2820181 caccccgatg acgtgaccgt cgacaatatc gggatgcgtg tggaggagtt cctcgatctc
2820241 ccgcggcgag atgttctcgc cgccccggac gacgaggtct ttgatccggc cggcgatccg
2820301 cacgtacccg gacgggtcca tctcagccag atctccggtg tgcatccagc cgtcggcgtc
2820361 gatcacctcc gcagtcttct gcgggtcatt ccagtacccg gccatcaccg aatagcctcg
2820421 cgtgcagaac tcgccgacca ccccgcgcgg gaccgtctcg cccgtggccg gatccaccac
2820481 cttgatctca aggtgtggac ccacccgacc gaccgtgccg acccgtcgat ccaccgagtc
2820541 gtcggcgcgc gtctgcgtgg aaaccggtga cgtttcggtc attccatagc agatcgagac
2820601 cccgggcata tgcatgcgtg agatcacctt gcgcatcacc tcgaccgggc acgcggcgcc
2820661 ggccataatc ccggtgcgca gactgcccag ttcgtagtcg gtgaagtccg gcaggcccag
2820721 ctcggcgatg aacatcgtcg gcacgccgta caagctggtg catcgctcgt cctgcaccgc
2820781 gcgcagcgtg gccgcagggt caaagcccgg cgccgggatc accatggccg ccccgtgact
2820841 ggtggccgcc agatttccca ttaccatgcc gaagcagtgg tagaagggca ccgggatgca
2820901 aatccgatct tgtgcggtgt acccgagcag ctcgcccacc aggtagccgt tgttgaggat
2820961 attgcggtgg cttagcgtga cacccttcgg gtatgccgtt gtgccggagg tgtattggat
2821021 gtttaccgga tcactgccgt ctagcctcgc cgcggtctgc tgcagcgcag gcagatcggg
2821081 ctcggcaccc gccagcgcgt cccagcgatc gctttccagc aaaatcacgt cggccagatc
2821141 ggggcatcgc ggcccaacct cggccagcat cgcggcatag tccgcatcct tgaaactcgc
2821201 tacggcaatc accatcgcga caccggactg cctaagcgca tactccactt cgcggacccg
2821261 ataggcgggg tttatggtca ctaggatcgc gccgatctca gcggtcgcgt actggacgag
2821321 cacccactcc caccggttcg gcgcccagat gccgacccga tcgcccgggc cgatccccgc
2821381 ccgcaccagc cccgtcgcca gccggtgcac gtcagtcagc agttcgctgt aattgaaccg
2821441 tcgccgggcc accatgtcca cgagtgcttc ccgatgtccg tacctggcag cggtcgctgc
2821501 gaggttggcg ccgatggtcg actcgagcaa tgatggcgca ctcggaccgc gatcatagga
2821561 aagccgattg gggtctacga cttccgcggc tgccacggtt cctccgcctg gtgcctaccg
2821621 catgtctgac tcgcgttaac atcgaatagc tcgtgctacg ttagtgacga ttaaccgaag
2821681 tgtccagcat gagtcgtgta cggagaccgt cgtgacagcg tccgccccgg acggtcggcc
2821741 cggccagccc gaggccacaa atcgtcgcag tcagctgaag tccgaccgac gattccaact
2821801 cttggcagcc gccgaacgat tgtttgccga acgaggattc ctggcggtgc gactggagga
2821861 catcggcgcc gccgcgggcg tcagcggtcc ggccatctac cgacacttcc ccaacaaaga
2821921 gtcgctgctg gtggaattgc tggtcggcgt cagtgcgcga cttcttgccg gcgcacgcga
2821981 tgtgacgacc cgcagcgcta acttggccgc ggcactggat ggcctcatcg agtttcacct
2822041 tgacttcgca ctcggcgaag cagacctcat ccggatccag gaccgggacc tagcgcacct
2822101 gccggccgtc gctgagcggc aggtgcgtaa ggcccagcga cagtacgtgg aggtctgggt
2822161 cggggtgctg cgcgagctga acccaggcct ggccgaagcc gacgcccggc tgatggccca
2822221 cgccgtgttc ggactgctga actccacccc gcatagcatg aaagcggccg acagcaagcc
2822281 ggcacggacg gtgcgtgcac gcgccgtcct acgggcgatg acggtcgccg cgctatcggc
2822341 cgcggatcgt tgtctatagc tcgccaggct gcgatgtcgc cgggtacatc agcgcacccg
2822401 cacccagcgc gggtaccctg catgccatga ggtggacatg aacgatccac gtcgccccca
2822461 gcggtttggt ccccctctat ccgggtacgg gccgaccgga ccgcaggttc cccccaatcc
2822521 gccgaccgcc gacccggctt acgccgacca gtcgccgtat gcatccacgt acggcggtta
2822581 cgtttccccg ccgtggtctc caggagggcc cccgccaagg cctccccagt ggcccccagg
2822641 cccccacgag gccagtccga cccaacagct gccgcagtac tggcaatacg accagccccc
2822701 accgggcgga tttccccccg acgggctgac tcccccgcca ccgcaagggc cgagaacgcc
2822761 gcgctggttg tggttcgccg ccggctcagc cgtgctgctc gtcgtcgcgt tggtcatcgc
2822821 actggttatc gccaacggct cggtcaaaaa gcaaaccgcg atcgagccgt taccccccat
2822881 gcccgggcct agcccgacac gtccgaccac gaccacaccg accccaccct cacccagcgc
2822941 cgcaccggca ccgacaacta cgaccggtac gcccagtgag acggtcgccg gcgcgatgca
2823001 aaccgttgtc tacgacgtca cgggggaagg ccgggcaatc agcatcacgt acatggatag
2823061 cggcaacgtc atacagaccg agttcaacgt cgccctgccg tggcggaaag aggtcagcct
2823121 gtcaaagtcg tccttgcatc ccgctagcgt cacgatcgtc aacatcggcc acaacgtcac
2823181 ctgctcggtc accgtggccg gggttcaggt acgccagcgc accggggcgg ggttgaccat
2823241 ctgcgacgct cccagctagg aggattgcgc cgtcgtcagc gcaccgccgt gccgcgacac
2823301 ctgtacccgc agcatgagca gcaggccggt tgtcaacacg aggcacacgc cgccgagccc
2823361 ggcacggacc gtgtggaaca cgtcgacgaa gaccgaaaac aaccacggcc ccagaaacga
2823421 caccgcccgg ccggtcatcg tgtagagccc aaaggccaca ccctccttgc cgtgctgcgc
2823481 catatgcagc agcagagcgc gtgccgacga ctgcgccggc ccgatgaaca cacacaacag
2823541 cagcccgcac gcccagaacg ccgttgggcc cgacaacgtc agcaacgtga gcgccgcggc
2823601 gatgatggcg gccagtgatc cgacgatgac cggtttggac ccgatccggt ggtcgacgaa
2823661 cccacccagc acggccccca ccgcagccac cacgcttgcg gccgcaccaa agatcaggac
2823721 atcggcctgg gtgagcccgt atgcgttgac gccaagtacc gcgccgaagg cgaaaatggc
2823781 cgccagcccg tcgcggaata tcgcgctggc caccaggaag tagaccaagt tgcggtcgcg
2823841 ccgccactcc gcgctgatct ccgtccacag cttgcggtag ccgcccagca ggccggtcga
2823901 aggatgagac gccgcaccgg aatcgggtag tcggtgcgcg accaacaaca atggcaggcc
2823961 cagcaacgcc aaccaggccg ccgcaaccag catcgccatt cgcacgttga gtccgttcgc
2824021 gacgggtagc tgcagcaggc cgcgctgcga accgctacct gacatgaaac ccagatagat
2824081 caccagcaag agcgcgacgc tgccgacata gcccgacgcc caaccgaagc cggagatccg
2824141 gcccgccgtg ctgggtgtgg acagttggcg cagcatcgcg ttgtacggaa cgctggacaa
2824201 atcgctggac gccgcggtgg ccgcgagcaa aaccagcccg gcccacaggt agcgggggtc
2824261 gtcgcggatc aggaacattg cgcaggtcag cgcgaccgcg gtgccggtca gcacagacag
2824321 tgccacccga cggcggtgcg gagactccac ccacacgccg acgacgggcg ccagcacccc
2824381 gatggtcaac ccggcgaccg cccccgcacg acccaaccaa ctcgccggtg aggtgccgcc
2824441 cggcagaccc tgacccacgg cgctggtcag gtagacggag aacacaaagg ttgtcacgat
2824501 cgcgttcaga ccggtggaac cgcaatccca catggcccac gccaccaccc ggaagtgcag
2824561 gagggtgccc gcgcgcgacc ccgggttatt catgtccggc actttattgc ttttggcagc
2824621 gacccgctgc gcccggctcc gccgcgctcg cgatcgctac gtgtctacga ttggcgcatg
2824681 ccgatacccg cgcccagccc cgacgcacgt gccgttgtca ccggggcttc gcagaacatc
2824741 ggcgcggcgc tggccaccga actggccgca cgcgggcacc acctgatcgt caccgcacga
2824801 cgcgaggacg tgttgaccga gttggctgcc cggctggccg acaagtaccg cgtcacggtc
2824861 gacgtgcgac cggccgatct ggccgatccg caagaacgat cgaaactggc cgacgagctg
2824921 gctgcccggc ccatctcgat cctgtgcgcc aacgcgggta ccgcgacatt cggcccgatc
2824981 gcatcgctcg atcttgccgg cgaaaagacg caggtgcagt tgaatgccgt ggcggtgcac
2825041 gaccttacgt tggcggtgtt gccgggcatg atcgagcgca aggccggcgg catcttgatt
2825101 tctggttcgg cggccggcaa ttcaccgatt ccctacaacg ccacctatgc cgcgaccaag
2825161 gccttcgtga acaccttcag cgaatctctg cgcggtgagc tacgcggctc cggcgtgcac
2825221 gtcacggtgc tggccccggg cccggttcgc accgagctac cggatgcctc cgaagcgtca
2825281 ctggtcgaga agctggtgcc ggacttcctg tggatctcga cggagcacac cgcccgggta
2825341 tcgctgaatg ccttggagcg caacaagatg cgcgtcgttc cgggtctgac gtcaaaggcg
2825401 atgtcggtgg ccagccaata cgctccgcgc gccatcgtgg cgccaatcgt gggtgccttt
2825461 tacaagaggc ttgggggcag ctaggcatca cttccggcgg cggcgcccgg tgccgaagat
2825521 gctgcgggtg atctcgcgtg cggtggtgtt gaggacgctc ttgacggtcg gattcttgag
2825581 tatctcctcc cacaccgcgg ggccctgcgg ctccaccgga gcgggcatcg gcggaacttc
2825641 aaaatcgtcc ggccagggca gcggatcgta ctgccccctt ggggctgggg cctcctgggc
2825701 cggggcctct tgcgccggcg cgagtttggc gctcagtatc tcgtgggctg acgggcggtc
2825761 gatggtctgg ccatatacgg cctgcaacga gcttgcctgg gccgcggcgc caatcgcttc
2825821 ggctccgatc gcggccatca gcgaccgtgg cgctcgcatc ctggtccagg cgaccggcgt
2825881 cggtgcgccc ttctccgata gcacggtgac gacggcctcg ccggtgccca gcgacgtcag
2825941 cgcggactcc aagtcgtaga catcggtttt cgggtaggtg cgcacggtct tgcgcagcgc
2826001 cttgtggtcg tcgggggtaa acgcgcgcag cgcgtgctga attcgggctc ccagctggga
2826061 gaggacatcg ttgggtagat ccgtgggcag ctgggtgcag aagaacaccc caacaccctt
2826121 ggaacggatc agcttcacgg tctgctcgac ctgctcgaga aaggccttcg aggcatcggt
2826181 gaacaacagg tgcgcctcgt cgaaaaagaa caccagtttg ggcttgtcca ggtcacccac
2826241 ctcgggcagg aaggtaaaca ggtccgccag cacccacatc agaaaagtgg agaacatcgc
2826301 cgggcgcaac gcctggctcc cgaactccag caacgagatg atgccccgac cctggctgtc
2826361 gacgcgcagc aggtcctcgg gcctcagttc gggctcaccg aagaatgtgt cggcaccttc
2826421 ggcttccagg ttgaccaaag cccgcaggat gaccccggcc gtcgtgggcg acaccgcccc
2826481 aagggatttc agctctacct tgccctcatc actggtcaga tgggtaatga ccgcccgcag
2826541 atccttcagg tccagcagcg gaagtcctcg ttggtcggcc cagtgaaaga tcaggcccag
2826601 tgtagattcc tgggtagcgt tgagccccaa cacctttgcc agcagaatcg ggccgaagct
2826661 ggagatggtc gcacgcaccg gaaccccgac gccactggca cccagcgaca ggaactccac
2826721 cgggaaggcc gtcggcaccc agtcgtcacc ggtgtctttc gcacgggcgg ccgtcttgtc
2826781 ggcggcctcc cccgggcggg ccagaccgga caaatcgccc ttcacgtcgg ccatcagcac
2826841 tgccaccccc gccgcactga gctgttcggc gatcagctgc agcgtcttgg tcttgccggt
2826901 tccggtggcc ccggcgacca gaccgtgccg gttgacggtg gccagcggaa tgcgaatctg
2826961 cgcgctcggg tcgggttcgc cgtcgacgac gacggtgccc aactgcaggg cctggccttc
2827021 gacggtgtaa cccgccgcga tccgctgcgc gggcccgcca ggtccaccgg ccgccgattc
2827081 ggtgcccata gctggatcac actacttgcc cgggggagac agccgcgacg gctcgcatgc
2827141 gcctacgctg agcgctgtgc aagacgaact ggtgtggatc gactgcgaga tgaccgggct
2827201 cgatctgggt tcggacaagc tgatcgagat agccgccctg gtcaccgatg ccgatctgaa
2827261 cattctcggc gacggggtgg acgtggtgat gcacgccgac gacgccgcgc tgtcgggcat
2827321 gatcgacgtg gtcgccgaga tgcactcgcg gtcggggctg atcgacgagg tgaaggcatc
2827381 cacggtcgac ctagcgaccg ccgaggccat ggtgctcgac tacatcaacg agcacgtcaa
2827441 gcagcccaag accgccccac tggccggcaa ctcgatcgcc accgaccgcg cgttcatcgc
2827501 ccgcgacatg cccacgctgg actcgtttct gcactaccga atgatcgacg tcagctcgat
2827561 caaggaactg tgccggcgct ggtatccgcg gatctacttc ggccagccgc ccaaggggct
2827621 gacgcaccgg gcgctggccg acatccacga atccatccgc gaactgcggt tctaccgccg
2827681 caccgcgttc gtgccccagc ccggcccttc taccagcgaa atcgcggccg tcgtcgccga
2827741 gctttccgac ggggcgggcg cgcaggaaga aacagattcg gccgaggcgc cccagagcgg
2827801 ttaatatcga cgtcgccgct cattagcccc cgcgggggcg gccggcggcc atggtgagtg
2827861 tagttcagtt ggtagagcac caggttgtga tcctgggtgt cgcgggttcg agtcccgtca
2827921 ctcaccccaa cagggcggca gggtgtttat ggccctgggc cctttgctgt ccccgccgag
2827981 ggcgtgcacc tgcaaccttc gtgtctatga tctggtcctg tggcgaattc gaccactcgc
2828041 cgcgactgca cctggccgcc cgctccaaca cccgccggtc aaactgccat cggacagcat
2828101 gttccccgtc gccagggcct tggcaggtgt cggtttgccc ggtctatttg cctgccgcgc
2828161 aactatcgca cctccggcgt ggcttgttcg gactcactcg gtgtttcgtg ccatggttga
2828221 tgtgcaggac gtttgagacc ccaaccagct agaccaggat gagcgcttct gcgtcagccg
2828281 acaaggtcgt atgcgagtgc tgcgagctct gtgttcctaa acagctcgcg tcagcgattc
2828341 gcaacccata cggactcgtc cgtgggtggc gctgtcgcat ctgtaacgag caccaaggcc
2828401 agccggtcaa gatggcgcaa gaccacgaag aggaggtccg catccgttgg ggcgagacgg
2828461 tggacgaact ccacgctgcg ctggaccgcg ccgggccaag gccagggacg tggtgtacga
2828521 gtgaaggttc ctcgcgtgat ccttcgggtg gcagtctagg tggtcagtgc tggggtgttg
2828581 gtggtttgct gcttggcggg ttcttcggtg ctggtcagtg ctgctcgggc tcgggtgagg
2828641 acctcgaggc ccaggtagcg ccgtccttcg atccattcgt cgtgttgttc ggcgaggacg
2828701 gctccgacga ggcggatgat cgaggcgcgg tcggggaaga tgcccacgac gtcggttcgg
2828761 cgtcgtacct ctcggttgag gcgttcctgg gggttgttgg accagatttg gcgccagatc
2828821 tgcttgggga aggcggtgaa cgccagcagg tcggtgcggg cggtgtcgag gtgctcggcc
2828881 accgcgggga gtttgtcggt cagagcgtcg agtacccgat catattgggc aacaactgat
2828941 tcggcgtcgg gctggtcgta gatggagtgc agcagggtgc gcacccacgg ccaggagggc
2829001 ttcggggtgg ctgccatcag attggctgcg tagtgggttc tgcagcgctg ccaggccgct
2829061 gcgggcaggg tggcgccgat cgcggccacc aggccggcgt gggcgtcgct ggtgaccagc
2829121 gcgaccccgg acaggccgcg ggcgaccagg tcgcggaaga acgccagcca gccggccccg
2829181 tcctcggcgg aggtgacctg gatgcccagg atctctcggt agccctcggc gttgacgccg
2829241 gtggcgatca aggtgtgcac tccgacgacg cggcctgcct cgcgcacctt gagcaccagg
2829301 gcgtcggcgg cgaggaaggt atacgggccg gcatcgagcg ggcgggtccg aaacgcctct
2829361 acggcttcgt cgagctcttt ggccatgatc gacacttgcg acttggaaag ctttgtcaca
2829421 ccaagtgttt cgaccaggcg ctccatccgg cgagtggata ctcccagcag gtagcaggtc
2829481 gccaccacgc tggtcagtgc gcgttcagct cgcttgcggc gctgcagcag ccagtccggg
2829541 aaatagctgc cctggcgcag cttggggatc gcgacgtcga tggttgcggc acgggtgtcg
2829601 aaatcacggt ggcggtagcc gttgcgctga ttggaccgct catcgctgcg ttcgcggtag
2829661 cccgccccgc acagggcgtc ggcttcagcc cccatcaagg cggcgatgaa cgtcgagagc
2829721 agcccgcgca gcagatccgg gctcgcctgt gcgagttggt cagccagaag ctgctcggtg
2829781 tcgataagat gagaagaggt cattgcgtca tttccttcga ttgacttttg ctggtcgttt
2829841 cgaaggatca cgcgatgacc gcccactact gggctacgac acgcccaccg gccttacctg
2829901 cccgtacacc acacccctgg acgtaactcc gcgccgatga ctacaaggca aagatgctgg
2829961 ctgcgtttag gtctcacgat gccgtgttaa gagagttcga aaagctcggc cgctatcatc
2830021 agtcaaccgg gcacggctgc ctctgcggca aacgaaactg tgcaacgctg tccatcatcg
2830081 atagcaacca gatatatggc cacattgacc gaatgaatcg ccgcgacgag cttggctaag
2830141 ccacaacaga gagaaacaag gtggacgaca tcgcagcatt caagctcgac agcctgccgg
2830201 acataacctt cacggtcacg cgggccataa gttcgggtgg ggaaaatccg gcggggtttc
2830261 tcaatttcgc ggcgcgccga gagcaaccgg agatcctggg tggtggaggc cgtcctggac
2830321 cggtgggccc ggaagcggtc gatactccac gtattcgcgg cgggaaggtg ccgttcgtct
2830381 tccggacgct accgggttac accttctacg ccagccaaat cgagccgaga gtgggcgacc
2830441 cggaagggcc cacactcctg gctggattcg gcaatatccc tgagacttcg cagcggtcgc
2830501 cgggatggat ccgcatcacc tgcacggggc cagacgacga tgaggagctg gaattctttg
2830561 gattcgccgg gccagagtcc taaccaggcg atgaacgaag gatcggcgac ggctacgaac
2830621 ctggataggc aagaatggcg caccgaagcg tcactcgacg tcggccggcc ggagaacgca
2830681 ccacgaaacg aaacacttgt gaggaccaag attctccgat cttcgggtag cacccgagag
2830741 catgtcgtta ggcctgtcgg catgggcgcc ggcaaggtcc tccagccggg tgatgggcgt
2830801 cgcagagtac agacgtggct gctgtccgca ggctgaagcg gatgaagtga cagcccagcg
2830861 gcgcggccag aagctctcag aaagtccatc cctgcgcctc gatatagccc atcagagtta
2830921 gccacggcac gccaagagcg tcgcagacat cggggatgcg cggcttttcg atattgccgc
2830981 tcgcagtctc ctgggtaacc accgtggcgt tgttcaccat cgcgagcgcg atgacgaacg
2831041 ggtcggcggc gcttcgcctg ccaccctgcc ggaccatgtt cgggtgcaac cgcaagatgt
2831101 gccgcgccgc ctgctggatc tgttcatcca gaggacagaa caagccagtt tgcccgtccg
2831161 cccaccgctt cgcgtcatca tcacgcctgg cgagttcgcg ctgaacctca tcgaccgacc
2831221 tgatctgacc ggcgctgatc gcatcctcaa cccggcccca cagactgcga aacaccgctg
2831281 gccgaaacag atcacgccgt ccgttcagga tggcgctggt atcgaaggaa tagagcacag
2831341 cggttagacc acgctccgca gttcggctga ctcagccaac ttcggaatct ggctgacctt
2831401 ggcgtcgagg tagatcgcag cggtgttgct gtcgatgacg cggcggcggt gggcgtcggt
2831461 caccgcccgc acgtagccct taccgaggtc tcggacggta ttgcggtacc agttgccgcc
2831521 cccagccgat cgagcccgtt cggcctcgtc ctcgtgagcc gcgatgaact cggcgcggcg
2831581 ctgtcggtag acctcgaccg gcacgattcc aagcgtgctt agccgccgca ggaacgcctc
2831641 ggcactcacg ccaaaatgcg ccgcgaccgg ccgcagcgat tcgtaatccc acgaagacgg
2831701 agtctcgctg cgaacgatga cctccggccg cgctcgcacc acgtcggcag gcatcagcac
2831761 agcggcggcg atcgcgttgc atcgagcctc cagcgatcgg tcctgggtgc tcggatgagc
2831821 atcggcgatc acgtcacaca agccctcggt gtgcagcacc acgtgcacga actcatgcag
2831881 cagcgagaac aggcgagggc gggggtggtc gctgccattg agcacgatca ccggcaattc
2831941 gtcgaaatac agacacatac cgcgcatctc gtcgatagcg accttgccgc cgcgggtcgc
2832001 gagcaccaga acgccggacg tttcgatggc cgacacccag gcgttcagat gctcgtaagg
2832061 gtcaaccgag gccacgggga taggcaacgg gctgacctcg atcaaggcct tgcggattcg
2832121 tgccgcgata tccgcgtcgg cctcgtcgcc ggataggggc aaacgccagg cgcccggtat
2832181 ctcccggtcc tcggcgtcgg ccagctctag cgcgaagtcg cgttgcgtgt gtgcgcgacg
2832241 gaactcctcg tgaagccccg gcgtccattg acccgacgcg gcaccgtcca atcgtcggaa
2832301 gtcgcgtaag gtgtcaaacc cctcgggcgg ctcggacagg aagaacaccg ccagcgagcg
2832361 cttgtagacc tcggcggcct tgcgcagctg cgcgatggtt ggcacaacct cgcccacctc
2832421 ccaagccgcg acgcgatcat caggcaggcc gagtttgcgg gccgcggcta cctcggtcag
2832481 gccacacgac tcgcgagccc aacggagcac cgagctctcc accgaagcgg gaatcgaccg
2832541 catggcaatg atgatgcacc accccaccca cattggatgg ccgataccca cgcttggttc
2832601 ccgaccagcc gattaaccgc tcccccgcaa cctggcgaga cggtactcgc cgcgttcggc
2832661 gtctgggacg gtgtgccgtg agaccggctg cggtgtaacg ccttacgaac tagtgagcag
2832721 ggtgcaacgg gacggccgcc cactcgtcct gtccagccca acggacgtat agctgatttg
2832781 gaaggggatg gccccaagcc gctatcaaga ccatgttgag cccctctccg gggcgaatca
2832841 ccgtcttctt cgggacattt cgagtgatcg catcgattcg cgagaggtca atctcgacat
2832901 cttctgcgat atcgtcgccg atgttgcgca acacaaagcg gattttgtct gggttctcga
2832961 cacgccaccg gacgttaggt gccttaccgg acctgccgac cgccggtccc accgcccacg
2833021 agtacgcgaa cttggcagtc ccggtatgcg gccgaccggg ctttcgctcc caggtctccg
2833081 caaacctgcg caccgctgcc gcatcccaca ccgcgcctcc acgcaaatct gccaacggag
2833141 cgggaaaccc tgctgtcgac ctcaattggt gcaccctctg acgcgaaacc cccaactcat
2833201 ccgcgatctc agccgcagac atcaactcgg gcgttgtgaa cgcctcagcg cgcagacgat
2833261 gctctggctc gctaatgatc tgcacagcaa tgggactctt ggcttgaact accggcataa
2833321 cctcgccagc catcttggcg agcgcgtcga acacactcca atcgccgggc gcatagaccg
2833381 tgacgtcaat gccgtgtcct gggacccgag ataccagtgc gtcgaagccc tcgagctgcg
2833441 tctcccaggc gtccatggtc tccatcgaag ggtcagcatc aaacgtgaag gtgacgaccc
2833501 agtcggctgt cactgtgcgc cttccttcct gtgctgtgcc cgccgttcct tcttgctcgg
2833561 cggtggccac gtcaggcccg ctttcttcaa cgcgcccaat aggtctcgca tccggcggta
2833621 ctcgttgcta ggtgttgccg gaaaccgagc aatatagacg ccctgggggt tgtagaagcg
2833681 ggtgtagccg ctggcgtcat cctcaaccgt ccattgttgc gattgcgccc acttcgcgat
2833741 cttgatgatt gcgctgttca catcgtctcc ccaacacttg cgatgtgtca agagtaatgg
2833801 caagacgcga catcgtaaag gttttagccg gactcattcg aatatttgag cgatgtagcc
2833861 agtgagtggg tgctccgatg atcacggctt cgcgcgagct cgccccggct ggcctcatga
2833921 tcgccgaccg gctgggcttc acccggtctc agtggttctc ccagtcgcga aggaacaccc
2833981 gagtgtcgtc atggtccgcg cggttgggca ctgcggccat cggatgtcat cgtcgtacaa
2834041 cgaaccatgc ggtcgttgca gggcgtgtat caggcgctgt tggttgtctg gcgttcctcg
2834101 cggcgcgctt acgccttggc gttaccggcg cgccactggt cccacggaat gttccaatcg
2834161 ccgagcccgt cgatccccgg cagggtgcca cccacggtat tgaccacctc gacgatgtcg
2834221 ccgcgcttga catggtcgta gaaccactgc gcgttgctcg ggctgacgtt caggcagcca
2834281 tggctggtgt tggtgtggcc ctgagccccc accgaccacg gcgctgagtg cacgaagaca
2834341 ccgctgtagg agatctgggt ggcccagtcg acatcggtgc gatatccgtt gggcgagttg
2834401 acgggtacgc cgtaggtgga cgagtccatg atgatgtgct tgtaccgcga gccgacgatg
2834461 tatatgccgt tggccgtcgg ggtgctgtcc ttgcccatcg acgtcggcat ggactttacg
2834521 acctcgccat tcacccgcac ggtcagtatc ttggtgttgt cgtcggcggt cgcgatcacc
2834581 tcgtcgccga tggtgaagtg cgtctgcacg ttgtcctcgc cgaacattcc ctcgcccaag
2834641 tcgacgccgt aggtgttgac cgccacatca acggccgtac ctggcttcca gaaatgctct
2834701 gggcgccaac gcacttcacg gttattcagc cagtagaacg cgccctccac gggcgggttg
2834761 gtggtgatct tgatggcctt ctcggccgcg ccccggtcag cgatgttctc gtcgaatcgg
2834821 atcgccaccg gctcgccgac acccacgacc tccccatcac cgggcatgac gtagggcatg
2834881 gtcaggtgcg cgggggaact ggtctggaag gtcagctggc gggtcgccgc gccacccagt
2834941 ccaagcgccg tcgcgttcag cgtgtagcgc ctgttgtagc cgagctgctc agtggtcgac
2835001 cagcgcagtc cgtcggggct gagtcgaccg gccaccggcc tgccgttgtc gttgaccatg
2835061 gtgacggccg ccagcacacc gtcggcggcg gtcaccgaca ccggtgcatc cacggtgacg
2835121 ccgacggcgc cgtcggtgac cgacgcggtg agcttgggca ccagcagatc ggcgaacggc
2835181 gtgcccttgt ccgcgatgac cttgatcggt gcgggtccgc ggccgctgcc gcatgcgacg
2835241 gcaccgatca tcacggcggt catcatcagc gcggttaacc aggctctccg aaccctggtc
2835301 ctacccgcct gagctgcaat ccccaccttt ggcatgcctt ccctcacctc ccccactgcg
2835361 tcgtgaccga gctagactcg gctgtagtct aggtcctgac tggccgccac gctgcgatgc
2835421 tgataccaag ttcagtgtga gatttcacgc gagagcgcaa ggcctgttaa tgtgccttgg
2835481 ctaggtaatc gaggcgccgt tagctcagtt ggtagagcag ctgactctta atcagcgggt
2835541 ccggggttcg aaaccctgac ggcgcacagg tcaacgcgtt atttcggatg caccagccgc
2835601 agctgtcccg ttgggcgacg atttccgtat tcggaaggtg cacgccggtt accggatttg
2835661 ggcagcggat cggatcggag ccacggggat agctcgacga gacagccggg gaagccgcag
2835721 aaaattgggt tgtaggcgcg tgcaatagct acgctgcatg tggacagcgg ggaagaggtt
2835781 agttgtgtcg cgtctgatcg tggctccgga ctggctggcg tcagcagcgg cggaggtgca
2835841 aagcatcggc tcggcgctga gcgcggcgaa cgccgcggcc gcggccccca ccaccctatt
2835901 ggtggccgcc gccgaagacg aggtatccgc agcggccgca gcgctattcg ccaactacgg
2835961 ccgggagtat cagacgctga gtgtgcggtt cgcctcgctt gatcagcagt tcgcgcaagc
2836021 actgaactcg gcggcagcgt cgtatcagac ggccgaagcc acgggtgcgt cgctcgtgca
2836081 gaccgcgaca caaggtgtac tgggtgtgat caatgcgccc accgagttca tgttcggacg
2836141 ctcgctgatc ggcgacggag ctgacggcac ggctgccagc cccatcggcg agcccggcgg
2836201 aatcctgtac ggcgacggcg gaaacggcta ctcccagacc acgcccggag ctgtcggcgg
2836261 agccggcggg tcggccggat ttatcggtaa cggtggcgcc gggggcgccg gcgggcccgg
2836321 cgccggcggc gggactggag gcctcggcgg ctggttatgg ggcaacaacg gcgccgctgg
2836381 caccggcgac ccagttaacg ttgccgtccc cctgcgcgtg gaaaacaact ttccgctggt
2836441 gaacctcttg gtcaaccgcg ggccaactgt ccccatactg ctggacacgg gatcctcgag
2836501 tctcgtcatc ccattctgga aaatcgggtg gcagaacctg ggcttgccca ccgggttcga
2836561 tgtcgttcac tacggcaatg gcgtgagcat cgtctacgcc gacgtgccca cgacggtcga
2836621 tttcggtggc ggcgccgcta ccacaccgac ctccgtccat gtcggtatcc tgccgtaccc
2836681 gcgaaacctt gacagcctgg tcctcatcgc ttccggcggc gctttcggac ccaacggaaa
2836741 cggcatactg ggcatcgggc cgaatgtggg gtcgtatgcc gtcagcgggc ccggcaacgt
2836801 tgtcacgacc gatttgccgg gccaactcaa cgaaggcacc ctcatcgaca ttcccggcgg
2836861 ctacatgcag ttcggcccca acacgggcac tccaatcacc tccgtgaccg gggcaccgat
2836921 caccgtgctg aacgttcaga tcggcggcta cgaccccaac gggggctact ggtcactccc
2836981 ctcgattttc gattcgggcg gcaaccacgg aacgcttccg gcggtgattc tcggcacggg
2837041 ccagacaacc ggttacgccc cgccgggcac ggttatctca atctcaatac atgacaacca
2837101 gacgctgctg tatcagtaca cgacaaccgc gagcaacagc ccagtggtca cggcagaccc
2837161 ccgactcaac accggtctaa ccccgttcct gctgggaccg gtatatatct cgaacaaccc
2837221 tagcggtgtc gggacggtgg tgttcaatta cccgccaccg tagctttccg ccgggtccag
2837281 aaccgccgcg ccataagggc gtcacgttcg tccagaacct cggctaagtg cggagtgcgc
2837341 aatcatggtg cactgcaatg ggtttcccat cggtaactcc gggttggtca gcgattcctg
2837401 atcttgtgga tgaccacgac gacgaccaca gacccgatcc cgaccagtga cacggtcacg
2837461 atgggcttcc tgaggaaggc gatcacccga gtttttgcgt cgtcggcgag gcggcggggg
2837521 ttggcgcgct cggcgaggga atcgatggtc gccgccagtt ggtcgcgggt ttggtcgatc
2837581 tcctgcttga tggtattggg atcgcggtcc accacgtgct gtcctccaag ttctccagtc
2837641 gcccactgcc ggcctgcgtc gcccgccgaa ctaccctaga tcagtgacca aaaccacgcg
2837701 tctgaccccc ggagacaaag cccctgcctt caccctgccc gatgccgacg gcaacaacgt
2837761 gtcgctggcc gactaccgag gacgccgcgt catcgtgtac ttctacccgg cggcctcgac
2837821 accgggatgc accaagcagg cttgtgattt tcgcgacaat ctgggcgatt tcaccactgc
2837881 cggcctcaac gtcgtcggta tctcccccga caagccggag aagctcgcta cgttccgcga
2837941 tgcccagggc ctgacgtttc cgctgctgtc tgatcccgac cgcgaggtgt tgacggcctg
2838001 gggtgcctac ggggagaagc agatgtatgg caagacggtg cagggggtga tccggtccac
2838061 cttcgtcgtc gatgaagacg gaaagatcgt cgtcgcgcag tacaacgtca aggccaccgg
2838121 ccacgtcgct aagcttcggc gcgacctgtc ggtatagccg cgagcttggc cagcagcagc
2838181 gcttcggcgg tcgccgcgcg ttccagcaca cccagatgca ggctttcatt gacactgtgc
2838241 gcctgcgttc cggggtcttc taccccggtg acaaggatgg tcgcctgcgg gaacgcggcg
2838301 gcgaactcgg cgatgaacgg gatcgacccg cccattccca tatcgatcgg atcggcaccc
2838361 cacgcctgcc gaaacgccga ccgcgccgca tcatagacag ggccgctcgc ctcgatggcg
2838421 tagggctgtc cgacctcgcc gcgcgtgaca gtgacctggg cgccccaggg ggcgtgccgc
2838481 cgcagatggg cctccaccgc gtccaggtgc gccgtggcat cgcctccagg cgccacccga
2838541 atactgatct tggcccgggc ccgcgggatc agcgtattgg acgctgccgc aacggatgtg
2838601 gtgtcgatgc cgattacggt gatcgccggc ttcgcccaga gccgctgcgg caccgagccc
2838661 gtgccgattt ccgatactcc gtccagtaga cccgactcag cgcgtacccg tccagccggg
2838721 taatccacac gcgccgcggt gctttcgtgc atgcccgcca cggccacgtt gccgtcgtcg
2838781 tcgtgcaggc tggccaacag ccgcactagc acggtcagcg cgtcgggaac gacgccgccc
2838841 cacaacccgg agtgcagccc gtggtcgagg gtggcgacct cgacgacgca gtcggccatt
2838901 ccgcgtagcg acaccgtcaa agccgggatg tcggtgctcc aattgtccga gtcggcgatg
2838961 acgatcacgt cggctgccag cgcgtcacgg tgggcggcga gcaaccggcc cagtgacggc
2839021 gacccggatt cttcttcacc ctcgacaaag accgtgacgc ccaccggcgg tctgccgccg
2839081 tgtgcccaga atgcggccac atgcgtggcg atacctgcct tgtcatcggc ggtgccccgc
2839141 ccgtagagcc gcccaccacg ctcggtcggc tcgaacggcg gcgacaccca ttgcccgcgg
2839201 tcaccctcgg gctggacgtc gtggtgggca tagagcagca ccgtcggcgc ccccggcggc
2839261 gccgggtacc gcgcgatcac cgccggcgca ccgcgctcgc tgacaatccg cacgtcgtca
2839321 aaaccggcct gcgacaacag gtctgccacc gcacgcgcgc tgcggtgaac ctcgtcgcgc
2839381 cgatctgggt cggcccacac cgattcgatg cggaccagct cctcgagatc acaccgcacc
2839441 gacggcaaca cctcacggac gcgctcaacc agctcgcgag cagacgcaga gtcgcatgaa
2839501 aatccggatt tcgatgcgat tctgcgtctg ctcgcgctca cggggcctcc aggatggcga
2839561 ccgcggccgc ggtatcccct tcgtgggtca gcgacacatg gatcgtcacg tcggccaaat
2839621 actcagcgat ggccccggtc agcctgaccc gcggcctgcc ccacatatcg gtgaccacct
2839681 cgatatcgcg gtggatgtcc tccggcaaca ccggccgctg cgcgaaccgc gatccggacc
2839741 aggccttgat caccgcctcc ttcgcggccc agcgggccgc caggtgccgg gccgccgacg
2839801 aactcttgtc cgaggcgtcc cggcgctcac ccggggtgaa ggtctcggcg aacaccgttc
2839861 cgggctggtc gacctgctcg gcgaaatcgg gaatggagac caggtcgatc cccacaccga
2839921 cgatgcccat gggcggccac gttaatcgat ggcccagtcc ggcgacgatg cggtccgcgt
2839981 tgggggcacc tcccgcttgc gggggacgga ccgaagagat gccgggcagt caggccaagg
2840041 agcacgcggc gagcgtgtat ccatggcggc gacacgccga acaccgtcgc cctgagcgca
2840101 cgttcggcgc ccaacggcag ggtcagccga tatacgcctc gccgtcaccc agccgggccg
2840161 ccggattcag cagcatcgac gcctcctgcg gccgctcggg cgcgtggtgg tcgaagcgac
2840221 ggtcaccggg ccgctggtac atcggcgcac caccggcaat cgccgaggcc agccggcgct
2840281 gaccggccag caggcgggcg tcggcacgcc gctggtagtc cgcgcgctgt gcgggatcca
2840341 gcgaggcgat gaacgcctgc ggatgcacca acgcgaccag gcccgacaca tggccgaacc
2840401 cgaggctggt cagcatgccg gccttgagtg ggaacttgcc gccgagccgc aacgtgtcac
2840461 gcacccacac gaaatgcgcg gagccggcca gctcgtcgtc gacgcagtcg aggctgcggt
2840521 tgggtgggat caccccatcc cgcaatatct ggcagagccc catcatctgg aagaccgccg
2840581 cgccgccctt ggcgtggccg gtcaggctct tctgcgacac cacgaacagc ggggcgccct
2840641 cggaacggcc cagggcgtcg gcgagccgtt catgcaactc ggtctcgttg ggatcgttgg
2840701 ccagcgtcga ggtgtcgtgc ttggagatga ccgccacgtc gtcggcggcc acgcccagct
2840761 tggccagcgc ccgcgccagc ggtgaatcct tgccgccgcg gcccgccccc agcgcgccca
2840821 ggcccggggc cgggatcgag gtgtgcacgc cgtcgccgaa cgactgcgcg aacgccacca
2840881 ccgccagcac cggcagcccc atccgcagcg ccaggtcccc gcgggccaac aggatcgtcc
2840941 cgccgccttg ggcttcgacg aagcccagac ggcggcggtc gttgggccgg gaaaacttcg
2841001 agtcgtggat gccgcggccg cacatcatgg acgtgtcggc ggtggcggcc atgtcaccga
2841061 atccgatgat gccctccagc gtcaggtcat ccaggccgcc ggccaccacc agttgagcct
2841121 tgcccaaccg gatcttgtcg acaccttcct cgaccgacac cgcggcggtg gcgcacgcgg
2841181 ctaccgggtg gatcatcgca ccgtagctac cgacgtagga ctgaaccacg tgcgcggcaa
2841241 tgatattcgg caagacttcc tggaagatgt cgttcggctt gttgcggccc aacagattgc
2841301 cgtggtacat cgtctgcatc gacgtgccgc cgcccatgcc ggtgccctgg gtgttggcca
2841361 ccaaactcgg gtgcacgtaa cgcatcacct cggccgggct gaaaccggac gacaggaacg
2841421 cgtcgacggt cgccaccatg ttccataccg ccaaccggtc gatggaaccg gccatgtctg
2841481 cgctgatgcc ccacaccgtc gggtcgaacc cggtcgggat ctggccgccg acgacgcggg
2841541 acagcttggt ctttcgcggc acccggatct cggtgccggc cttgcggatg acctgccagt
2841601 cggtggagtc gggcaccggc cggatgaccg tgtgctcggg atcgaactcg acgaaggcgc
2841661 gcgcatcggc ctccgaggac accacgaacg cgaagtcctt ctccaggaac accgacacca
2841721 gcagcggcga ggcgtggtcg gggtcgatcg cgccgtcatc aacgaattcg cgaatgccga
2841781 cgcgctgcac cacggcgtcg tggtagcgct gcaccaactc ggattcgtcg accatttcgc
2841841 cggattcggt gtcgtaccaa ccgggttgcg ggtcgtcctc ccagcggatc aacccagtgg
2841901 tccaggccag ctccagcacg ccggccgccg acagctcgtt ttcgacctcc atctcgaacc
2841961 gggtgcgtga cgagccgtac gggccgattt cggcgccgcc gacgatcacc accaggtcgg
2842021 ccgggtcgac atcgaggtcg tcccattgcg gcggcggtgc gggggtgaaa ccccggggcg
2842081 gcgacggcag cgcggcgatg gcgccagggg cctcggcgtc ctcgtcgacg gccgccgctg
2842141 ccgacatctg ctcgcgcgcc ttggccgcca gctcggccat gtcgaggttg gcctcggcca
2842201 ggcccccggt caggtcggcc ttgatcggcg aacgcgccgc agccaccttg gattccgcat
2842261 cacacaggtc gagcagcagc gccgccatct cgtcggtcga gtaggtggtg accccggcct
2842321 cttcgacggc ggccacgatg gcatcgttgt ggcccatcag cccggtgccg cgggtccagc
2842381 cgatgagcgc gtgcgccagg ctgacccgtg ccgcccagga cgactcggcg tgccagcggc
2842441 tcaccacggc atccagcgcg gacttggctt cgccgtaggc gccgtcgccg ccgaacatgc
2842501 cacggttggg cgagccgggc agcaccacgt gcagccgcga cgcgatgtcg cgttcggcgc
2842561 cgatcgtcga caggccgccg atcagccgtt gcacggccca cagcagcact ttcatctcca
2842621 tctcggcgcg cgaaccggcc tccgacaggt ccccgaccac gcgtggcgcc gcgaacggga
2842681 acagcagcgt cggggtctgc gcgtctttga tgtgaatcga ctgcggccca aggctttcgg
2842741 tctgttcggt gccgatccat tcgaccaggg cgtcgacgtc ggagtaggac gccatgttcg
2842801 ccgcgaccag ccacagcgcc gcgccgtaac gggcgtggtc gcgatacagc gtgcggtaga
2842861 acgccagccg ctcctcgtcg agcttggagg tggtcgcgat gacggtggct ccgccgtcga
2842921 gcagccgagc caccaccgac gcggcgatcg aacccttcga agcgccggtc accacggcaa
2842981 cttcgccgcc gtagcggccg ggttcggggt tctcggcgcc ggcggcgatg cggccgtaca
2843041 gcgatgcatg gatctgccgg cccgcggcca gcgacttacc ttgccaccag gtagcctggg
2843101 tcgccacgac gtggccggca ccctcgaagc gctccgccag gcgcggccag tcggcgtcga
2843161 tgtcgccctc gtcggtcagc cacagcttca ccaggtcctc gcgggcgctg gcccagcggt
2843221 cgtcgaatac gacggccttc ttggggtcga acaccggtgc caccaaccgc ggccagtccg
2843281 ctcccagttc ggcggtgacc aagtcgatca gctcggaatc gggggcggcc ggcaaggcgt
2843341 tgacggggtc gtccagtccc agctgcccca gcaccaggcg ggccgcggag gccagcacgc
2843401 cctcacggcc ggtgatttgg tcggtgaact cgctgagcgc ggccgcgtcg atggtggcgc
2843461 cgccaccact accggccgac ggcagcgcta ccgaaacgcc ctggcgcgcg gccaccgatg
2843521 cgaccgccgc gtcgatgacc ttgtcgacgg aggcggcatc ggccagcgcg ccctcgtgca
2843581 ggtggcccat ggcgccgccg cgaacgctgc tgccctcgcg ggtgcccagc gcgacctcga
2843641 cggtgacatg cttggcccag ccctcaccga gctcccaggt cttcttcacc cgctcggcga
2843701 tggcgccggg ccgcttgccc gacggtccga ggacggtgcg aagctggtcg ttgatggcgt
2843761 cggaaagcac tgggccgtaa ggcttgtagg tgcgcgccag tttggtcacc tgtgagcgca
2843821 gaccggccag gtccgattcg gcggcgccgt caatggcacc gaggttcagc tcggagccca
2843881 ggtccaccag cagctggttg cgccgcgacg acgcaccgtc ggtgatggac tcgatggagt
2843941 cgagttcttc gatctggtcg atgcgcatct tggccgagag cgcgatcagc gccagcgtgg
2844001 catcggcggc gtcgaaaacc agatcgtcgg gacgcgggcc cgccgacgaa gcggccggcg
2844061 cgacgggggc ggcttccgag acgacgtccg gcgcgggcga ttccgcgacc ggctcgtctt
2844121 cctccggctc cggctccggg tcggtgtcgg tggcgaacag caccgcggca tcacgctcgg
2844181 cgttgagcac ttccactgtg ctgtgggcgt attcgggcag tttgagggtg ttggtggcaa
2844241 gacccgccac cgtcggtgag ctcttcacac cgatctcgac gaatcgctcc acacccagcc
2844301 cgccggcggc ctcctcgatg aacagcagat cctgcgtctc gatccagcgc accgggctgg
2844361 cgaattgcca tgccagcagc tcgatgaaca ccgtgcgcgc catctcgcgc ggacgctcgc
2844421 gaagccaggt gtcgtagtcg gcgaggatct cgtcgagcgg ctcggcgggc accaaatccc
2844481 ggatttcctg gatgaagtcg cggtccaggg tgaacaaccg cggcaccagg ttgggaatgt
2844541 agcgcccgat gatcaggtcg gggtccgcgt cgcgcggcat gacccggtcc agcgagcgcc
2844601 ggaattcggc caccccgacc cgcagcactc gcgagtggaa cggaacatcg atgccgggca
2844661 ccaaaatgaa cgaccgtcgg ccgccggtga gctcgcggcg ccgctccacc tcggcctcga
2844721 gcgcctcgag gccgcgtacc gtgcccgcga tcgcgtattg cgagccacgc aggttgaaat
2844781 tcacgatctc caggaattca ccggtgctct ccgcgatccc ggcgacgaac gcgggcacgt
2844841 cggcgtcgtc gaggtcgatc tgggacggcc ggatggccgc cagccgatag ttggagcggc
2844901 cgagctcgtc gcgcggaacg atgtcgtgca tcttcgaccc gcggtgaaac accatctcca
2844961 gcaaggcttc cagttggtag atgccggtca cgcaggccag cgcggtgtac tcgccgaccg
2845021 agtggccgca cgcgatggcg ccttcgacga aggctccctg ttcacgcatc tcggcgacct
2845081 gcgcggccgc caccgtcgcc atcgcgacct gggtgaactg cgtcaggtag agcaccccgt
2845141 cggggtggtg gtagtgcaca ccgctggcga tgatgctggt cgggttgtcg cggaccacgt
2845201 gcagtaccga gaagcccagg gtgtcgcggg tgaacttgtc cgcggtgtcc cacaccttgc
2845261 gggccgcctt ggagcgggcg cgcacctcca tgcccatgcc cttgtgttgg atgccctggc
2845321 cggggaatgc gtagaccgtc ttgggtgcgg ccagtcgcgc ggaggccgac atcactagat
2845381 ccgacccgac gcgcgcggcc acgtccacaa tctctgcgcc ctggtcgatt ccgacgcgct
2845441 cgacgcggaa gtccacctcg tcgccggggc gcaccatgcc caaaaaccgc gcggtccagc
2845501 cgaccagccg ggccggtggc cgggcctgcc cgtcggtggc ggtcaccgcg tgttgcgccg
2845561 cggccgacag ccacatgccg tgcacgatcg gcgactccag gccggcaagc agcgcggcgg
2845621 cccggtcggt gtgaatgggg ttgtggtcgc cggacaccac cgcgaacggg cgcatgtcga
2845681 ccggcgcggt gatcgtgacg tcgcggcggc gacggcgcgg ggtgtcggtg gcgttcgccg
2845741 acaccgcgcc accggctcgc gccgggtcgg cgagctcggc ggaaccggtg cgacccagga
2845801 tcgcgaatcg ctcctcgaga gtggcgatca cggcgccatc ggcgccggta acgacgaccg
2845861 agaccggcac gacgcggccc atgtccgtat cggttgcgtt ggcagccgtt gcggtgacgg
2845921 tcaattgggc cgggaccgtg ggcagctgac cgaccacgcg ggcggcgtgg tccagatgca
2845981 ccaggctcag caggccttcc accaccggct caccggtgtc ggtgaccgcc gatccgatgg
2846041 ccgcgaaaac cgctggccaa caagggccga cgagcgcgtc gggcacgttg gtgaggctgg
2846101 gtgccagcgg ctcaccgaac gtggcggtga cgccggtgtg gtcggcaaca cgctcggggt
2846161 gccagtccac cgtcaaagtg gccgtcccgt tggccaccgc aggcaagaac tccgggctgt
2846221 cgacaccggc ggcgatcgcc agcaccgtgc gcatggcgct ggtggcgtcc tcggtggcga
2846281 tcaccggggt gccgccatcg acggtgttgg ccggcaacgt gaatcggatg tcgacccagg
2846341 tgcccgagac gggcacgctc aaggcgacgt cgtcgccgtg cgtctgcagc cgggcgccgg
2846401 tggatgagtg tgtggcgcgc gggttttcgg gtccatcgtg cacctgccat tcggccgggt
2846461 cggcgatccg atgcaccggg ttggtcacgg tgcgaccggc ccagcgcaca tcgggtgcgt
2846521 cgaggacgac agccaacggt ccggccacgt cggcgcggcc cagccggcgc gacgcgacat
2846581 ccttcggctc gacaccggcg ccgagcactt catcgattgc ggcttgctcg aaacggtcca
2846641 gcaactcacc gacgggttca tccatccggg tgatgccggc taccgacgcg gtgcccggaa
2846701 tgatgcacac cgcatcggcg tcgtagcggg cgtcgtgggc ctgccacagc gagtcgctgc
2846761 gccaccagcg ccgcacgtcc tggtcgatca ccggcacgaa gttgaccggc ttgcccagcg
2846821 tcttgcacaa cgtcacgaaa aagggcacat ccgcgggatg caactgcacg gtctcggcgt
2846881 cggggtagcg cgccagcagg gcggcgatcg cctgctgcgg attgtccagc aggccagcat
2846941 cggtgaatag cgtctggatc gggccgaaat cctgtgggtg caaccgggct tcggcacgct
2847001 gcagcatctg ctcgaagcgg tcccgccagg tgtcggccag ccacgggctg cccaccgagg
2847061 cggtgtcggc ggtcgagttg ccttccccga tggccagttc gacgtagcgc cgcagccact
2847121 gcaggtaggt catgtcggcg acgtcgccga agtagggctt ggcggtcttg gccatcgccg
2847181 cgatgatctc gtcgcgacgc tccgcgaccg cctccgcgtc accggccacc tcgtcgagca
2847241 gccgcccgca ccgggatgcg ctgttgtcga tctcgtggat atcggcaccg agctgactgc
2847301 ggctggaggc catgccgccc tgcgcttttc cggcgctgat ccattggtcg gtgccctgag
2847361 tgtcgacgag catccgcttg accgatggcg acgtggtgga ttccttggtg gccatcgccg
2847421 cggtgccgac caggatgccg tcgatcggca tcaatgggaa gccgtaggcc tgcgcccagc
2847481 gcccggacaa atattccgca gcccttctcg gggtgccaat gccgccgccg acgcacaccg
2847541 tgatgttggc gcgtgagcgc aactccgagt aggtagccag cagcaggtcg tcgagatcct
2847601 cccaggaatg gtgcccgccg gcgcgcccgc cctcgacgtg catgatcacc ggcttggtgg
2847661 gcacctcggt ggcgatgcga atcaccgagc ggatctgctc gatggtcccg ggtttgaaca
2847721 cgacgtggct gatgccgatg tcgcccagtt cgtcgatcag ctcgacggcc tcgtcgaggt
2847781 ctgggatgcc ggcgctgatc accacgccgt cgatcgcggc gccggactgg cgggccttct
2847841 gcaccaaccg cttgccgccc acctgaagct tccacaggta gggatcgagg aacagcgcgt
2847901 tgaactgata ggtgcggccc ggctcgagca ggccggccat ttgttcgatg cggttaccga
2847961 agatctcttc ggtgacctgc ccgccgccgg ccagctcggc ccagtgcccg gcgttggccg
2848021 ccgcggcgac gatcttggcg tccacggtgg tcggggtcat gcccgcgagc aggatcggcg
2848081 agcggccggt cagccgggtg aacttcgtcg agagcttgac cctgccgtcg gggaggcgaa
2848141 ccacggtcgg tgcgtagctc gaccaggccc gggcaacctc gggggtggcg ccgacggtga
2848201 acaggttgcg ctggccaccg cgggtagccg ccggcacgat gccgatgccc aggccgcgga
2848261 tcaccggtgc ggtcagtcgg gtcaggatgt cgcccggccc caggtcgagg atccagcggg
2848321 cgccggccgc gtggacacgg gtgatctcgt cgacccagtc gacctttctg atcaagatgg
2848381 catcggccag ctcccgagcc aaggcgacat cgaggcccgc cttctcggcc cagcccgcga
2848441 cgatgtcgat cccgtcggat agccgcgggg tgtgaaagcc cacctccacc tgcaccggct
2848501 cgaagaccgg cgagaagacg tcgccgccgc ggaccttgtt cttgcggtcg gcttcttcct
2848561 tctcggagat ctggcggcaa taaagctcga aacgcgacag ctgctcgggg gtgccggtga
2848621 tgacgacggc acgccggccg ttgcggatgg acaacaccgg tggcagcacc gtgcgcacgt
2848681 cctgggcgaa ctcgtcgagc aaccggccga tgcgctcggg gtcggcgttg gtgaccgata
2848741 ccatcggcgg gcgatcgccc aggacggaaa ttccgcgccg gcgggccacc agcgttccgg
2848801 cggcaccgat caactgggcc aaggcaaaca gctcgacgtc gcgtgcccca ccagccttga
2848861 gggcttccac cgccagcaca ccttgcgaat gccccgccat ggcgaccggc ggggtggcca
2848921 cgaggtccat gccttgacgg gccagcgccc gggtcgccgc gatctgggta agcaacacgc
2848981 cgggcaccga cacggcggcc gacgtcaggt gcttgtcgga cggaaccggg tcctcggccg
2849041 ccagtgcgcg tacccattgc agcggctcga aaccgatcgg gcgcaccaca atcagctcgt
2849101 cggtgaccgg atcgagcaac agctctgcct caccgaccaa cgtcgccaac tcggtttcta
2849161 tcccggtggc cgacaccagc tcttcgaggg tttccagcca ggcgctgccc tggccaccga
2849221 atgcgacagc gtagggctca ccagccatga ggcgatcgac cagagcgtgg gtggtatgcg
2849281 ggctgtcccc gccgcgatca gcggacaccc ggtcgtgctc gtggatcgtc acggtctatg
2849341 tctccctatg tgcatcggta cgtgtcagtt cgtacagcgg cccaggctgc cgtgcggggc
2849401 atccccgact ccgcaccgac tcccagccga aatcctctga ccggtgtgtt gtcggtgggc
2849461 cggcccgtgg gtcgagcagc gcgacgggct gcatcggcct tataagagtc tcataaggat
2849521 cggtccacct tgtttacaca gatcggttac tggcgagttc tacgtacggg taaccgtgtc
2849581 gtgggtaacg ccgggttcga cggccggcgc gtatgtgttg accaaacgtc ctgcgtgcag
2849641 gtggttacgg tggagtagct ataactgcgc tgatcaaggc agttttgtta tcaaatcgtt
2849701 atgctgggaa ttcgctctac gccgggcgcg tgccgacgcg ccgacccaaa ggccgcgcca
2849761 ttggcggcgt tggcccgggg ttggcaatgc cgtgcagcgg gcgaacgagt gtttgctgta
2849821 gtgcagcggg ggccaggctc ggggcggcag gctaagccca ctgcccgaat tggggcttca
2849881 ggatttggtt gacgtccacc ccgaccccac caaccttgcg cttatcgatc tccacctggt
2849941 gcagatgcgc ggccgggtgg gtgtatccct tgggcgagcc ccagttgtgc tgccagaagt
2850001 acgagcccaa gccatcgttg acggcccagt cgatggtttt ggagttggcg tacacgccgg
2850061 tccgctggtg tccgatcacc gactcccagg accgcagata tggcacgatc tggttcttgt
2850121 actgctcata tgatgggttg tcgtcgatcg aggcgtagat cggggcgctc gtcgggccgc
2850181 cggcagcggc atgcagctcc gacccccgtc tggcgtgctg cacgccggcg ctggcaccgc
2850241 ccagccagtc ggcagtgctc cccttgccgt attgataaca ggacacgatc ttgagcccat
2850301 tgccgctcag gtcacgggcc tcgctgagct ggatcggctt gccaagcatc caggcgccgc
2850361 caggccgccg atcggacacg taccggattg cccccaccgc gccggcagcc ctgatctggc
2850421 tggcggggat gacaccggcg gcgtagtcca acagggtgcc cagcgaaccg gccgatgccg
2850481 gcgcggcgcg caacgacgac gcaacgacgc caagacccag cacgcccgga gtcgccgccg
2850541 cgaatttgag cacatcacgc cgagagaccg acatatgcca cagggtacga caaaaacaac
2850601 aactgtcaca ctggtttcag tggtcacgga tgcatcacac tggcagaaca catgcatgcg
2850661 gccataccga caccggtgcg gtctcgggca ggccgcctct ccctgcgacc actactacgg
2850721 tgtgatcgcc tacgctccca acggcgcaat gggcaaaatc gtcgcgccac cgcactcgag
2850781 gccaggcgga tatcgacgca taagaacttt gcggcgtctt agctgcaaag tgctcagcaa
2850841 cttcaccaac taccacgggg gagtccgacg atcgcgcccg ctggcagaac ctggacgtgc
2850901 aaccagttga gtagttccca cactgcgcgc cgagcgtggg ctggctgcgc cgaatgtgca
2850961 ctggtggcgg cgacacgccc gggcgacgcc gccgtggttg cacgttcggc gtaggcagcc
2851021 ccgtgcgctt gccgggcagg tgtcctcaaa ggtccaacta gacacacata tcagacacta
2851081 gtatgtacat atgaccgtaa agaggaccac gattgagctg gacgaagatc ttgtgcgggc
2851141 agcccaggcc gtcaccgggg aaacattgcg agcgacggtc gagcgcgcgc tgcagcagct
2851201 ggtggccgcg gctgccgagc aggccgccgc gcgccggcgg cggatcgtcg accatctcgc
2851261 gcacgccggc actcacgtgg acgcagacgt gctgctctcc gagcaggcgt ggcgatgacc
2851321 acctggattc tggacaagag tgcccacgtg cgactcgtgg ccggcgccac gccgccagcc
2851381 ggcatcgacc tcaccgacct cgccatctgc gatatcggcg aacttgaatg gctgtattca
2851441 gcacggtcag ctaccgacta cgacagccaa caaacgtcac tgcgcgccta tcaaatcctt
2851501 cgcgcaccca gcgacatctt tgaccgggtt cgccaccttc agcgcgacct agcccaccac
2851561 cgtgggatgt ggcatcgaac gccgcttccg gacctattca tcgccgaaac cgcgcttcat
2851621 caccgggccg gcgtgttgca ccacgaccgt gactacaaac gaattgccgt cgtacggcct
2851681 gggtttcaag catgcgaact ctctcgcggg cgctagcttc gcccgaatcc gtgagcggag
2851741 gcgataatcc ttacaggcca tcaaaaaagt cctcgtcgag ccgtaagagt tcgacggtct
2851801 gcaccgcctg gacaccgact cgataccgca cgagcagctc ggccagccga gcgccgtcga
2851861 tgagttcgat ccgggcgttg atccgctcag cttcctcgcg ggcaccgcgg gaaaacgatg
2851921 acgtggtgat gtagacgccc cggtcgccct gcttgcccag gagggcgccg gcgaactcgt
2851981 ggatcttcgg ccggccaatc gtttggtcga cggcgtatcg cttggcctgc acgtagatgc
2852041 ggtccagccc gagcgggtcc tggctgatga ttccgtcgat gccagcgtca ccggaggcac
2852101 tcgtccgttc caccgcgccg gctcgcccgt aacccatcgc ctccaaaagt ctgataacca
2852161 gatcttcaaa cccggtgggc gacaacgtga gtgccttctt caggatctcc ccctcgacgg
2852221 ctgcccggtt ctccgcaagc gcagcgtcga tgagatcctc gggtgagacc tgcacatcgt
2852281 ccccggacgg tcgcttggcg gtcgcgtcga ctggctgctt ggctttggtt cgctcacgaa
2852341 aagcgatgta cgacgggaac tcccgcagca cagccatgtc gacgcgctcg ggatgcgcct
2852401 tcaggacttg acggcccgtg tccgtgacct ggacgtggcc ccgcgtggga cggtcgagca
2852461 atccggcctg cgacatgtga gtgagagacc agtgcaccct gtcgtacatg gtcctttgcc
2852521 gaccgctggg caacatctgc gcccgctcgt cgtcggacag accgaactcg tcggacatcg
2852581 ccgcgatgac gtccttggcc gacttcgctt gtccatcggc aagatacgcg agaatcggcc
2852641 gcatcaacgt ctgggcatca gggatcgtca tggggagcca ttatccagct ggcttgtcag
2852701 ccctccgaac cggccaagtt gggtaagtcc atccggggct ccgtgttctg acaggcccgc
2852761 tgcaggcgtc gcatcttcct catctgcccc acgtgtaccc ggtcccgccg acctaaaagg
2852821 tcggcatatc cctgccatgc cgggacgcgt gaggcgggtg agacacaagg gaacgtgcac
2852881 ctcgcgcacc gggtcgccag cagccgcgac acgccgtcgt ccagtgccac accgaatgcg
2852941 gtgtcgggct cggcgtcaaa cgctgccgat cggccttgcc tcgtcaggcc gccgacagca
2853001 ccgccctggg ctcacggtcc gcggctccgc cgggatccga ccggcggcgg ctcaaccccc
2853061 tcgatcgtct tgagccggtc gacagaccga tcgaaagacg gccaccggat cgtcccggca
2853121 ggggcgagga agtccggcgt ccgagcaagc accgggcgat tgccctcaac gcggaagaca
2853181 acccgatcac ccgattgcag gccgagcgcg tcgcgcaccg ctttcggaac cgtcacctgc
2853241 cccttcgacg tgacgatggg ttcgtcggag tgcctgcttc accgttgccg tacgccgccc
2853301 gtaccctcac actctgtgga gctgctcgtc gccgccaacc ccgctgaaga ctcgcgcctg
2853361 ccctacctga tccggctgcc ggtgggcgcg ggactggtct tcgccacctc agacgtgtgg
2853421 ccgcgcacca aggcgctgta ttgccatcgc ctcgacatcg ccgactggcc cgccgacccc
2853481 gtcgtcgtcg accgggtcga gctacgcagc tgcagccgcc ggggcgcggc catcgacgtc
2853541 gtcgccgccc gcgcgcggga gaaccgatcg caactggtgc acaccatggc gcgcggccgc
2853601 caggtggtgt tctggcagag ccccaaaacg cgcaaacagt cgcggccggg cgtgcgcacc
2853661 cccaccgccc gcgccgccgg catccccgag ctgcacatcg tcgtcgacgc ccacgaacgc
2853721 tacccctaca cctttgccga caaacccgcg aagacgacgc gggaagccct gccctgcggc
2853781 gactacggcc tgaaagtggc cggccaactc gtggcggccg tcgagcgtaa agcgttggcg
2853841 gaccttactt ctggcgtgct gaacggcaac ctgaaatacc aactgaccga actggccgcg
2853901 ctgccacggg ccgccgtggt ggtcgaggac cgctactcgg agatcttcgc gcactccttc
2853961 gcccgcccga cggcgatcgc cgatgggctg gccgaattgc agatcggctt tcccaacgtg
2854021 ccgatcgtgt tctgccaaac ccgcaagctc gcccaggaat acacctaccg ctatctagcc
2854081 gccgccctca cctggttcgt cgacgatgcc gacgccacca cggttttcga gccggctgcc
2854141 gccgagcccg agcccagcag cgccgagctg cgcgcgtggg ccaaaagcgt cggcctgccg
2854201 gtgtccgacc gggggcgcct gcgcccgcag atcctgcagg cctggcgagc cgcccatccc
2854261 cggtgactac aacacctcga cgaggcctgc ggatgctgaa tcggccagtg cggcatcgaa
2854321 tgtgaccaac cggcccccgt agcgcgcggc caaggcgatg agatggcagt cggtgacccg
2854381 acggtggttg gacaccgcat cgcgatcgcc ggcgctccca acgatcagtg gcacatcgtc
2854441 aggccaaaac gtgtgcccgg caagagaagt catcgccgcc aactgagcga tcgcgatagc
2854501 cggcgtggtc gacacctgca tcacactgcg attgcttgaa attcggacat accctgcctc
2854561 ggtgatcggc gtggtggccc acccattcga ggagaactgc gtgaaccatc gctgcgcggc
2854621 cgcatggtga acgtgattcg gccagcccag cgcgatcagc acattgacat cgagcagtgc
2854681 cgtcacacgt cgtcctcgag cgcgcggacg acatcctcgg aagtcaccgt cggcgcatcc
2854741 ggcggaacat caaaaaccgg aaatccgtca acctcgacaa tcccaaccgg acggagcgac
2854801 ctacgcgcca actcagaaat taccgcgccg actgacttgc cctccgaccg cgcgatgcta
2854861 cgagcatctt ctagaacatc atcatcaatc tgcaacgtgg tgcgcatagc atcatgttac
2854921 ggggcttggg ccagctttca cgcgtcttcg gcgaccccct gcagcacact gtcgccgttg
2854981 acggtgccat tcaaagccga agcgtcccgc ggtacctcga aggccggcag cgcggcacct
2855041 accgtggcga cggcgttgcg cgcggcctcc atccgggcca atgccgcctg ggtgaacacc
2855101 gacaacccca ggtcggggtt gtatccgtgg atctctttga cgtcgagctg ggcaagaaag
2855161 tagatgatct ccttggaaac cagttgaccc ggcaccagta ccgggaagcc gggcgggtag
2855221 ggcaccacga acgtggtgga taccagagtc ttgccctcag ccagccggcg cccggccaag
2855281 ccgatctgca cgtactcacg gtcggcctct tcgtagccgg cgtagaaagc cgaccgcatg
2855341 tcaccgaaag agctggcgtc gtcggggcgg aaggcaaggt cgaactcgct gaaatctggt
2855401 agatgcggca gatcctgcgt gatctcctcg acgtggcgtc ggtgtagagc aaggtcggcc
2855461 ccgctggccg ccttctggct gcggtccaga tcgatcgcca cccgacgcaa cacatcgagc
2855521 agatagtgca cgctcgacca ggtgacgccg atcgtgaaga tcagcaacac gctgttgata
2855581 gacgttttgt tgatctggat gccgaatcgc tccatcagga tcttctcgcg gaagtcgtac
2855641 ccgttcatcc cggtcgcccc gataaacagg gtgagccgcg tcggatcgag cacgaattga
2855701 tcggaccgcc aggcttcgtt ccaatcggcc agagccccct gcctgacctg acggtacgag
2855761 ctgaccgtcg aggaccgaaa ggcatcggga accaggtcgg actcgtcaag gatgcggaac
2855821 cacttgctga tcagccggtc tttgcggacg cgatggcgga acaccagcgc catgttgtaa
2855881 acatggcgga ccagctcgaa cccttcgatg tcaacctgtc ggcgcgccaa gtccaacgag
2855941 gcgagaagtt gctggttggg cgaggtcgag gtgtgggtca agaatgcctc accgaacgcg
2856001 tcccgggtga gcgctttgaa atcctggtcg cgcacgtgga tcatcgatgc ctgccgtagc
2856061 gcggacagcg acttgtgagt cgaatgcgtc gcatacactc ggacccgagc gcggttgggg
2856121 tctggcaaca gccggtgatc aacccactcg gagcggtcca ctccgtccat cgacgcacac
2856181 caattccggt attcctcagc gtattccgca gtggacaaca tctgctcgag tcgctcggca
2856241 gcaatcatcg cggtccgctg ccgggcccag ggcaccgccg tcgcaaacgc ataccacgcc
2856301 tcgtcccaca aaaagcagat gtccggtttg atcgctagca cctcctccat cacccggcgc
2856361 gggttgtaca ccacgccgtc aaacgtgcag ttggtgagca acagcatgcg cacccggtgc
2856421 agctgtccgg cggcctcgag gtccagcagc gcctgcttga tggtgcgcaa cggcacggca
2856481 ccataaatcg cgtactgcgg cagcggatat gcgtcgaggt acatcgggta cgcgccggca
2856541 agtaccaggc cgtagtggtg cgacttgtgg caattgcggt cgatgagcac gatgtcgccg
2856601 gggcgggtca gggcctgcac gacgatcttg ttggcggtcg atgttccgtt ggtgacgaag
2856661 taggtctggt tggcgttcca ggtcaccgcg gctttgtcca tcgccgtctt gatgttgcca
2856721 tgcgggtcca gcagcgagtc cagtccacca gaggttgtcg aggtctcggc catgaagatg
2856781 ttgcggccgt agaactcgcc catgtcgtgc agtgacttgg agttgaagat gctggcgccg
2856841 cgcgcgacgg gaagggcatg aaattggccg accggcgccg ccgcataggc ccgcagcgca
2856901 tcgaaaaacg gtgtggcata acggtttcgt aaacccgcga gcaccgtgct gtgcaggtcg
2856961 gtgacgtcgt tgagccggta gaaggtgcgg tcgtagacgt cgggctcgtc ctgggtctcg
2857021 gcggcgatcg actcgtcggt gagcagatag aggtcgatgt ggggccgcaa ctcacggatc
2857081 cactcggcgc attccaccca gtcgtgggtc tcgtttgcca ccgcttcgtc gccatcggtg
2857141 cccagcagcg tggtcatcag cggcacccgg tcgcgggacc gcagcggcag gtcgtgacgg
2857201 atgatcgccg cctgaatctc gccattcagc gccaccgcgg tgatggcatc ttcgatgctg
2857261 gccaccacga gcaactcgaa ctgcacctcg tcggccggat tgcgcaactg ccgcaggcac
2857321 tcggccaagc tgtccggagc cgtcgccggg gagtcgtcgg cgagcagcac ggtgtagaac
2857381 tgctgctgtt tggcctgcgc taccagctcc tgctccgcca gtgacgcgga ggtgtcgaac
2857441 agcgctgtgc ggtcgccgta ttcggacagc agtcgtacgg ccaacgacac ttcctcggta
2857501 agccgcaccg tggaatgact atccagatga gcgcggaaag tcgccagatt ctgtgccccc
2857561 ggatacagcc agtaccgctc ataggcgccg atgcggtcca tcagccgctt cgcccgagcc
2857621 acgtcgtgtg tggtgtcgag cccggcgagg tcgacctccg ccaggtgacg acacgcgtca
2857681 tcgagcaggt tccaggtgtc caggcgggtg taggacgggt tggccaccgc ggccagcgcg
2857741 gagacatgca gccgtcgcgg gcggacgctg tttgggttca tgtcgtcacc tgttctctgg
2857801 tgcgggtagc gccgtagagt gcaaccaggc aattatcgcg cgcaggaccg ggtcagtcag
2857861 ctaagtcgtc gctgtccgcg atccgccgat tagcccgatt cccggagttg tccacccagc
2857921 gcagcaccgg cagctgcgaa agctcccggc ggcgtgccgg cagatcggtg acgtcaccca
2857981 gcgagcgcac cacggcctgc gtcaggccca tgatggcggc catcaccggt agcagcggct
2858041 gcaacggctt tgccgccgtg cgaacagtgc tgatgcggcg tgccaagatc aggcgttcga
2858101 tcgcgtgata cagccaggcg ccgacaccca gcgcgtagat cgacattgcc gaggcgacaa
2858161 tggtcagccc gtaggcggcg cacaccacgg caccgagcac caccgtcgca gccaggacgg
2858221 ccgcgaccac gacgcgcagc tcgagccggg tcatcacgcc cccccacgca ccgcttgagc
2858281 ggccgcacgc agctgcgggg tcaccagcat gacctggccc agcaccccgt tgacaaagcc
2858341 cggcgagtcg tcggtcgaca gctccttggc cagctggacg gcctcgtcga cgaccaccgg
2858401 ctccggcaca tccgccgcgt ggagcagctc ccataccgag acgcgcagaa tggcgcgatc
2858461 cacggcgggc aaccggtcca gcgtccagcc ccgcagatgc gcggtgatca ggtcgtcgat
2858521 gtgggcggcg tgttcactga cccctcgagc caccgcggcc gtgtacggat gtagccgggc
2858581 aatgtcgggc ttcgcttcgg ccagcgcggc acgggtgtcg accacctcgg ccgcgctgat
2858641 gccgcggacc tcggcctcga acagcagggc caccgcgcgc ttacgggcct gatgtcgtcc
2858701 gcgaaccggc tttctgtccg acatcgtcag gcgttgaccc ggcccaggta gctaccgtcg
2858761 cgcgaatcca cctttagttt gtctccggta ttgatgaaca gcggcacgtt gatctgggct
2858821 ccggtctgaa gggtggccgg cttggtgccc gcgctggacc ggtcgccctg caagccgggc
2858881 tcggtgtgag tgacctcgag ctcgacggtc accggcagct cgatgtatag cggcacgccg
2858941 ttgtggaacg ccacctgcac cggcatgccc tccagcagga accgtgccgc gtccccgacc
2859001 agggcctccg gcagcgggtg ctgctcgtag tcttggctgt ccatgaacac gaagtccgag
2859061 ccgtcgcggt aaaggtaggt ggtatcgcgc cggtcgacgg tggcggtgtc caccttcacc
2859121 ccggcgttga acgtcttgtc gacgaccttg cccgagagca cgttcttcaa cttggtgcgc
2859181 acgaacgccg gacccttgcc cggtttgacg tgctggaact cggtgattgt ccacagctgg
2859241 ccgtcgatta ccaggaccag cccgttcttg aagtcagcag tggtcgccac gtgggtctcc
2859301 tacagaatgg ccagttcttt ggggaaccgg gtcaacaatt ccggggtctg cccggcggtt
2859361 tcaggcattt tcggcgtccc gccagccact accaatgtgt cctcgatgcg gacaccgccg
2859421 cggccgggta aatagacacc gggctccacg gtcaccacgg agcccgccag tagtgtaccg
2859481 gcggatgtga ccccgatgcc cggcgcttca tgtatctgca ggccaacacc gtgtcccagt
2859541 ccgtgaccga agtgctcgcc gtagccggcg tcggcgatca gctggcgcgc tgcagcgtcc
2859601 accccccgca gctcggcacc cggcagcaac gcctgccgac cggcctgttg cgcctcggcc
2859661 accagctgat agatctctag ctgccagtcg gcggccttgc ccaacacgaa ggtgcgggtc
2859721 atatcggagt ggtacccggc gaccagggcg ccgaagtcga tcttcacgaa atcgccgacc
2859781 tgcagcaccg cgtcggtcgg ccggtggtgc gggatcgccg aattggcccc ggcagccacg
2859841 atcgtctcga atgacaccgc gtcagcgcca tgatcgagca tcagggcctc cagctcgcgg
2859901 ctcacctgcc gttcggttcg gcccggccgc aggccgccgc gggccaccaa gtcggtcagc
2859961 gcggcatcgg ctgcttcgca ggctagtcgc agcagcgcca gctcgccggc gtctttaacc
2860021 tcgcgcagtg actccacagt tccggatgcc cgcaccaact cggtgttctt gccctccagc
2860081 gcgcccgcca aggcgtccag gccgtccacc gtgaccacgt ggctctcgaa gcccagcttt
2860141 cccacgccgg cctcgccggc ccggccggcc aggtagcgcc cgaccgcgcg ctcgatagcc
2860201 acttcgaggt cgggcgcttg cgaggcggcc tgagtgcggt accggccgtc ggtggccaac
2860261 acggcatcgc gctcatcggc gaacaccagc aatgcgccgt tggacccgct gaagcctgat
2860321 agatatcgca cgtttatcag gtcgctgatc agcatcgcat ccaacccgga ggcagcgatt
2860381 tgtgctttca gcttgtctcg acgctgggaa tgtgtcacga cccttgacgg tactcgctac
2860441 gctgaatgcc catgactaac tggatgctgc gcgggttggc gttcgccgcc gcgatggtgg
2860501 ttctccgcct gttccagggg gcattgatca acgcgtggca gatgctgtcc gggctgatca
2860561 gcctggtgct actgctgctc ttcgcgatcg gaggggtggt gtggggtgtg atggacgggc
2860621 gcgccgacgc caaggcgagc cctgaccccg accgccgcca agacctggcc atgacctggc
2860681 tgttggccgg cctggtagcc ggcgcgctca gcggcgcggt ggcctggctc atttcgctgt
2860741 tctacaaagc gatctacacc gggggcccaa tcaacgagct gaccacgttc gcggccttca
2860801 ccgcgctcat cgtctttctg gtcgggatcg tcggggtagc cgtgggccgg tggctggtgg
2860861 accggcagct ggcgaaggca ccggtgcgac accacgggct tgccgctgaa cacgagcggg
2860921 ccgccgacac cgatgtattc tccgccgttc gcgccgacga cagtccgacc ggggagatgc
2860981 aggtcgcgca gcctgaggca caaaccgcgg ccgtcgccac ggtcgaacgt gaggcaccca
2861041 ccgaggtgat ccgcaccacc gaaagcgata cacccaccga ggttatccgc accgacaccg
2861101 aggcggacca gaccaagccc ggcgacgagc ccaagaagga ttaaccctca cgtcccgaca
2861161 tgctcagcta ggtaccgcag ggccagcagg tagccctgga tgccgagccc gacgatcacc
2861221 ccggtcgcga tggggctgag gtaggagtgg cggcggaact cctcacgcgc atgcacgttg
2861281 gagatatgca cctcgatcag cggagcgctc agctccgcgc aggcatcgcg cagtgccacc
2861341 gacgtgtgcg tcagaccgcc ggcgttgagg atcacgggtt cggccgcatc ggcggcctga
2861401 tgaatccagt ccagcagctg ggcttcgcta tcactttgcc gcacaacggc tttgagtccg
2861461 agctcggcgg cctcacgctc gatcagagcg accagctcgt cgtgggtggt gccgccatag
2861521 acggcgggct cgcgccggcc caaccggccc aggttggggc cgttgatcac gttcacgatc
2861581 agttcgctca tggggcgcaa actccggcgt aggcggttac cagcagaccg gggtccggtc
2861641 ccaccattcg gcccggcttg gccaatccgt cgagcaccac gaaccgcaac acacccgccc
2861701 gagtcttctt gtcgccggcc atgatttcca gcagctgggg cagcgcgtcc gggtcgtagc
2861761 tgaccggcaa tcccaacgag gacaggatgg tgcggtggcg ctgcgcggtc gcgtcgtcga
2861821 gccgcccggc aagcctggcc agctcggccg cgaacaccag ccccaccgac acggcggcgc
2861881 cgtggcgcca ccggtagcgt tcccggcgct cgatcgcgtg gcctaatgtg tggccgtagt
2861941 tgaggatttc gcgcagctcg gattcctttt cgtcggcggc gaccacctcg gccttgacgg
2862001 tgatcgcgcg ccggatcagc tcgggcagca cgtcgccggc cgggtcgagt gcggcctgcg
2862061 ggtcagcttc gatgagatcc aggatcaccg ggtcggcgat gaagccggcc ttgaccactt
2862121 cggccatgcc gcagatcatt tcgtcgcgtg gcaaggtttg cagcgtcgcc aggtccacca
2862181 ggaccgccaa cggctgatga aacgccccga ccaggttctt gccggcgtcg gtgttgatgc
2862241 cggtcttgcc gccgacggcc gcatcgacca tgcccagcag tgtggtgggc aggtgcacaa
2862301 tcgagacgcc gcgcagccag gtggccgccg cgaacccggc gacgtcggtg gcggccccgc
2862361 cgccgaggct gaccagggcg tctttgcggc cgattccgat gcggcccaac acctcccaga
2862421 tgaatcccac gacgggcagg tccttgccgg cctcggcgtc ggggatctcg atgcggtgcg
2862481 cgtcgacgcc cttgccggcc aagcgctttc ggatctcttc cgcggtctcg gctagtccgg
2862541 gctgatgcac gacggcgacc ttgtgccggt cggccagcag gtcttccagc tcgtcgagca
2862601 ggccggtacc gatgaccacc gggtatggcg gatcgacggc cacctgcacg gtcacgggtg
2862661 cgccgatatc ggtcatgtgg ccgcctcgct ggggctggga acctgcagcc gcgacaggat
2862721 atggcggacc accgccccgg ggttgcggcg attggtgtcc actcgcatgg tcgcgacgcg
2862781 ccggtacagc ggtgcccgct tggccatcag cgcgcggtat ttttcggcgc ggtcggggcc
2862841 ggccagcagt gggcgcacgg tgttgccgcc ggtgcggcgc acgccctcgg cggcgctgat
2862901 ctccaggtag acgacggtgt ggccggccag cgccgcgcgc acaccggggc tggtcaccgc
2862961 gccgccgccg agcgacagca caccgtcgtg gtcggccagt gccgcgcgca ccacgtcctc
2863021 ctcgatacgt cggaactcct gctccccgtc ggtggcgaag atgtcggcga tgctgcgtcc
2863081 ggtccgctgc tcgatcgcga cgtcggtgtc gagcaggccg accccgagcg ccttggccag
2863141 ccggcgcccg atggtggact tgccggagcc cggcaggccg acgagaaccg ctttgggtgc
2863201 catctgttaa ccggagaccc gcgcggccgg tgcttcgcgg tcggcgacgc tgcgctggta
2863261 ggcggcgatg ttgcgctggg tttcggccag cgaatccccg ccgaattttt ccagcgccgc
2863321 ccgggccagc accaacgcca ccatggtctc caccacgacc ccggccgccg gcaccgcgca
2863381 cacatccgag cgctgatgga tggcgacggc ctcatcgccg gtcgccaggt cgacggtggc
2863441 cagcgcgcgc ggcaccgtgg agatcggctt catcgccgca cgcacccgca gcggctgccc
2863501 gttggtcatc ccgccttcca gccccccggc ccggttggtg gagcggacga cgccgtcggg
2863561 cccggggtac atctcgtcgt gggcgcggct gccgcggcgg cgcgcggtct ggaatccgtc
2863621 gccgatctcc acgcccttga tcgcctggat gcccatgacg gcggcggcca gctggctgtc
2863681 gagccgatgg tcgccgctgg tgaacgaccc cagccccacc ggcaggccca gcgcgaccgc
2863741 ctccaccacg ccgccgaggg tgtcgccgtc tttcttggcc gcctcgattt gggcgatcat
2863801 gtccgcctcg gcggccttgt cgtaggcgcg taccgggctg gcgtcgatgg cgggtaggtc
2863861 ctcggcccgc ggcggcggac cctcgtaggg tgccgacgcg ccgatcgaga tgacgtggga
2863921 gagcacctcg acacccagcg cctgcctcag gaatgcccgt gcgaccgtgc ccgccgcgac
2863981 ccgggcggcg gtctcgcggg cgctggcccg ctccagcacc ggccgcgcgt cgtcgaagcc
2864041 gtatttgagc atgcccgcgt agtcggcgtg gcccggccgc ggccgggtga gcggggcgtt
2864101 gcgtgcgacg tcggccagct cggcggggtc gaccgggtcg gcggccatca cggtctccca
2864161 tttgggccat tcggtgttgc cgatctcgat ggcgatgggc ccgcccaggg tgctgccgtg
2864221 gcgtatcccg gacagcacgg tcaccgcgtc gcgctcgaac gtcatccgtg cgccgcggcc
2864281 gtagcccagc cggcgtcggg ccagctggtc ggcgatgtcg gccgaggtga cgtgcacgcc
2864341 ggcgaccatg ccttcgacca cggccaccaa ggcgcggccg tgtgactccc ccgcggtgat
2864401 ccagcgcaac acctgaccat cttcccatgc gccgccggcg gccaccgcac gtcaacgcac
2864461 ccactccgtg cgatcgcggt gatgtgcggc cccccggatg ccccgctagc atccctggcg
2864521 tggaagtggc tggcggcacc cgggcccggc tgcgggtcac agccgatggt ttgcaggcgc
2864581 tggccgggcg gtgcgcgacc ctggccggcg aattgtcggc cgcggtcgcg ccgtcggggg
2864641 cggtgttgtc gtggcaggcc aacgcggtcg cggtgaacgc cgcgcatgcc cgcgcgggtg
2864701 cggccgccgc ggctgtgagc gcccgaatgc gggccaccgc cgccgcgctg gggcaggccg
2864761 cccgccggta cgcgggccag gacaccgcag cggcggccgc cctgggggcg gtacgcccgt
2864821 gggggaccca ctgatggcta cgtcggggct gccgccgctg tcggcggtgc agtcgacgag
2864881 ctttgcgcat ctgagcgagg ccgccgccca ctggcggcgg ctggccacgc ggtgggagcg
2864941 cgccttagcc gaggtgcgcg attcgatgcg ccgacccggc ggcaccgact gggagggcca
2865001 ggccgcggcc cgcgcccact accggtcgac cgtcgacgtg gtgacgatcg gtcgcgcggt
2865061 ggaccggctg catgacgccg ccgccgtcgc cggccggggg aagaccagct ggaggccaac
2865121 cggcgggcgg tgctggacgc tgtcagcgac gcccgccggg acgggtttgc cgtcggtgag
2865181 gattacacgg tcaccgaccg ctccacgggt ggctcacgcc agcagcgggc ggcgcgtctg
2865241 ggccaagccc aggggcacgc cgactttatc cggcatcggg tgggcgcgct gctggccacc
2865301 gaccgcgata tcgcgacccg ggtcagcgcc gccacccaag gcctcgatga gctggcgttc
2865361 gaagacgtgc ccggggtcga caccccggcc gaggatgggg tgcaggcggt ggatttccgc
2865421 caggccccgc caccgggagc ccccgggggc atgtcctccg gcgacatcga cgcgatcgac
2865481 gcggccaatc gcgccctgct gcaagacatg ctggcggagt acagccggct gcccgacggg
2865541 caggtgaaaa ccgaccggct ggccgacatc gcggccatcc aagaggcgct gagggtgccc
2865601 gactcgcatt tgatctatgt ggccaggccg gacgaccccg ccgacatgat cccggcggtc
2865661 accgcggtcg gcgatccgtt caccgccgat cacgtgtcgg tgacggtccc cggggtgtcg
2865721 ggaaccaccc gtcagaccat cgccaccatg acccaagaaa cccgtgggct acgagaagaa
2865781 gcgagagtga tcgcccacag cgtgggtgaa agtgagaatg tggcgaccat agcgtgggtg
2865841 gggtatcagc cgccgccggt gctcgcgtcg tggaacaccg ttgatgacga tctcgcgcag
2865901 gccggcgctc cgaagttgga ggcgtttttg cgggatctgc aggcgggatc gcacaatccg
2865961 ggtcacacga cggcgttgtt cgggcattcc tacgggtcgt tgctgtcggg gatcgcgttg
2866021 aaggatggcg ccagttcact ggtcgacaat gcggtgctgt atggctcgcc ggggtttgac
2866081 gcgacctcac cggccaagct gggcatgaac gaccacaact tcttcgtgat gaccacaccc
2866141 gatgacccca tccggtatcc ggcgcgcctg gcacccctgc acgggtgggg atcagacggc
2866201 gccgacacca tcggcactgt aggccgccaa ggcacccctg cacgggtggg gatcagaccc
2866261 caacgagatc atcgccggat ccccggaccg ctaccgcttc acccatctgc agaccgacgc
2866321 gggatccact ccgctgggtg atcacaagac cgccgccagc gggcactcgc aatacggcca
2866381 agacccgctg caacggatga ccggctacaa cctggcgacc atcctgctca accggcccga
2866441 tctggcggtg cgcgaaagcc cacagcagtg atcgcaccac aaccgatttc ccgaacgctc
2866501 ccgcggtggc agcgcatcgt cgcgctgacc atgatcggca tatcaaccgc cctgataggt
2866561 ggctgcacca tggatcacaa ccctgacaca tcacggcgcc tgaccggcga gcagaagatc
2866621 cagctcatcg acagcatgcg caacaagggc tcctacgagg ccgcccggga gcgcctaacc
2866681 gccaccgccc ggatcatcgc cgaccgcgtc agtgcggcca tcccgggcca aacctggaaa
2866741 ttcgacgacg atcccaacat acaacagtct gaccgaaacg gagcactgtg cgacaagctc
2866801 accgcggata tcgcgcggcg gccgatcgcc aacagcgtaa tgttcggcgc cacgttctcg
2866861 gccgaggact tcaagattgc cgccaatatc gtgcgggagg aagccgccaa gtacggtgcg
2866921 accaccgagt cgtcgctatt taacgaatcg gccaagcgcg actacgacgt gcagggcaac
2866981 ggctacgaat tccgactcct gcaaatcaaa ttcgccacac ttaacatcac cggcgattgt
2867041 tttctgttgc agaaggtgct cgacctgccg gccggacaac tccccccgga accacccatc
2867101 tggccaacga cctcgacgcc acattgatcg caccacaacc gattccccga acgctcccac
2867161 ggtggcagcg catcgtcgcg ctgaccatga tcggcatatc aaccgccctg ataggtggct
2867221 gcacaatggg ccaaaacccc gacaaatcac cgcacctgac cggcgagcag aagatccagc
2867281 tcatcgacag catgcgccac aaaggctcct acgaggccgc ccgggaacgc ctcaccgcca
2867341 ccgcccagat catcgccgac cgcgtcagtg cggccatccc gggccaaacc tggaaattca
2867401 acgacgactc ctacggccaa gacttctata gaaatggatc gttgtgtaag gaactcagtg
2867461 ccgatatcgc ccggcggccg atggccaaac cggttgactt cggtagcaca ttctcggcgg
2867521 aagacttcaa gattgccgcc aatatcgtgc gagaggaagc cgccaagtac ggtgtgacca
2867581 ccgagtcgtc gctgtttaac gaatcggcca aacgcgacta cgacgtgcag ggcaacggct
2867641 acgaattcaa cctgggccaa atcaaattcg ccacacttaa catcaccggc gactgttttc
2867701 tgttgcagaa ggtgctcgac ctgccggccg gacaactccc ccccgaacca cccatttggc
2867761 cgacgacctc gacgccaacc ccgtgagcac caccatcgtt gctggcgtga tccagggtca
2867821 cctgccggtg atcctgccca cgcgcaggcg ggctcgcgat ctcgggcaca cgacggcgtt
2867881 atttcgggcg caaacgctcc aatgcatata tctcagtatc gaatacctat atgtttgctc
2867941 catgtctcgg cgtacaacga tcgacatcga tgacatactg ctggcccgcg cgcaagcggc
2868001 gctcggtacc accgggctga aggacagggt cgatgccgct ttgcgagccg cggtgcgcta
2868061 gtcggcgcgc actcggctcg ccgcgcgaat cgcctcgggt gccggcatcg atcggtccga
2868121 ggcgctgctt gcccagacgc gtcccgcgcg gtgatggtgt tctgcgtcga caccagcgcg
2868181 tggcatcacg cggcgcggcc ggaagttgcg cgccgatggt tggcggcctt gtccgcggac
2868241 cagatcggca tctgcgacca cgtgcggttg gagatcctgt actcggcgaa ctccgctacc
2868301 gactacgacg cgctcgccga cgaactcgac ggcttggccc gtataccagt cggtgccgaa
2868361 acctttacgc gcgcatgcca agtccagcgt gagcttgccc acgtcgccgg tctgcatcac
2868421 cgcagcgtga agatcgccga tcttgtcatc gccgcggcgg ccgaactttc aggcaccatc
2868481 gtgtggcatt acgacgagaa ctatgaccgg gtcgccgcca tcaccggcca acctacggag
2868541 tggatcgtgc cgcgcgggac cctttaaccg ctgataggcg ccatcactgg atgtatggtg
2868601 atgtcatgcg gactcaggtg accctgggca aagaggagct tgagctgctc gatcgtgccg
2868661 ccaaggcgag tggcgcatcg cggtccgaac tcatccgacg cgcaattcac cgtgcctacg
2868721 ggactggatc caagcaggaa cggctcgccg cgctcgacca cagccgtggc tcgtggcgag
2868781 gacgggactt caccggcacc gagtatgtcg acgccattcg gggcgacctc aacgaacgac
2868841 ttgctcggct cggtctggcg tgaagctgat cgacaccacc atcgcggtcg accaccttcg
2868901 cggcgaaccc gcggcagccg tgctgctcgc cgaactgata aacaacggtg aggagatcgc
2868961 ggccagcgag ctggtccgat tcgaactcct cgccggtgtg cgggaaagcg aactcgcggc
2869021 gctcgaggcc ttcttctcgg cagtggtgtg gaccctggtg accgaggaca ttgcccggat
2869081 cggcggacga ctcgcccgtc gataccggtc cagccaccgc ggtatcgacg acgtggacta
2869141 cctgatcgct gcgaccgcca ttgtggtcga cgccgacctg ctcaccacca atgtgcgcca
2869201 cttcccgatg ttcccggatc tgcagccgcc gtactgagca ctccctgggg catcagcctt
2869261 ggtcggcgat gagttgttcg atgagctcga cgatgcgctg ttggccggcg gcggccccgt
2869321 ccagcttgcc tcgcatctcg gtgaatccgt cgtcgactcg actaaaacgt tcttctacgt
2869381 gactgaaacg ttcggtcatc tcttcccgca gggcggtgaa atcttctcgc agggcgttga
2869441 agctaccgat tgtagctcgc cggaagtcgc ggaactcgcc aacgaactcc gtgacatcgc
2869501 gatcggccgc gccggctagc acgcgagcgg cggcggcatc ctgttcgctg gcccgcacgc
2869561 ggtcagccag ctcacgcact tgggattcca gcgcggtgac ccgttgttcg aggttctcgg
2869621 gcagcacgag cgaatcctac cgcgattcaa cgcaacgcag ccctgtcccg ggcggacacc
2869681 ggcattgggt gcacgtcgga taagcagggc tgagcggggc tcggctctac tcgggtctta
2869741 cctcgacaaa tccggccgcg ctgaagtcac catcgaaggc atacgcattt tggatgcctt
2869801 tctttcgcat caccgcgaag ctcgtggcat cgacgaacga gtactctcgc tcgtcgtggc
2869861 gtacaagcca ttcccatgcc tgctcttcca ggtcggctgt tacgtgctcg acgcgaacga
2869921 cggtgctcaa gcggattgca gcggcggcaa ccgccgcgcg gtgaccgcag cgccggttga
2869981 gcagcgtcca ggtctcgccc aggacatggt tggaggtcat caccacgggc ggtttgctgg
2870041 cccacaacct cttcgcggtg ccgtgccgag cgtcgccggc gttgccaagt gcagcccaga
2870101 aggacgtgtc gacgaagatc attcgtgctt tccgtaaacc acgtcgtcga cggacgcgga
2870161 caagtcggct tcccccacga acgatccgac gaaggcatcg accggatctg ggcccggctg
2870221 ccggaggtgc tcagcgacgt actcccggat cagcgccgcc ttcgacgtcc gccgccgtcg
2870281 cgcttcaaca gcaagcgctc ggtcaacgtc ttcgtcgatg tagatctgca gccttttcac
2870341 atggcaaata tacgccacta gcataatgct gtatacatcg gtagccgaga atcggatgct
2870401 tgccgctggc tgccgagttt gttgaactcg ccgccgtggt gacctggatg aagtgtgccc
2870461 gccgaaactg ccgccgcccg actaggcgac tggccaaagc gatgacagtg ctgacttctg
2870521 tacaggggcg aagcgagtgt ccgccccttt acgcgcgtcg taatcagccg ctgagttcgc
2870581 catggttccc atgcaagatc gctcacgttc gagcccggcg cgcggtgacc gacatgaaac
2870641 tcccgttacg agcaagcatg cggcaacgcc gcctcgacgg cgacggtcca agctgtcctc
2870701 tgaacgaatc aggttgcgct aagccaagat tcgttgtcaa acgacctctg gtctacactg
2870761 atatcgcgcc aatctcagcc cagcagcgcc aaccccaccg cccccaggct ggccacacac
2870821 atcgacggcc cgtgcggcag ggtgcggaca ccccatggcg tcaccatcac gccgcacacc
2870881 gcggtcagca gcggcgcggc cagcgccgcc agaaaccaca cctcgacccc gaagcagccg
2870941 gtcagcccgc ccagaccgat cgccagcttg acgtcaccgg cgcccatcgc ggcgggcaaa
2871001 gccaggtgca ccagcaggta caccccggcc aaggcggccg ccccggccag cgccggcaca
2871061 ccgcggccgg caaggcccgc gaagagcagg atcacccccg ccccgggcag ggtgagccag
2871121 ttgggtagcc ggcgctgccg gacgtcgcaa acgcacaaca ctcccatcca ggccaacacc
2871181 gccgccgcca gcatgctggg gcacgctagt ccaacgcggc cagcgcgcaa gtcatcgctt
2871241 cgcggggggc gggtagcccg gtgaactgct ccacctgcgc gaacgcctga tgcagcaaca
2871301 tctgcagccc gctgatcacc cgcccgcccg ccgatccgac cgcggcggcc agcggtgtgg
2871361 gccacggatc gtagatggcg tccaacagca ccgggatcgc ggccaaggtg ccggcatacc
2871421 ccgcggccac ctccgctgga atggtgctga ccagcacttc cgcggcggcc accgcatcgg
2871481 ccaacccacc gctgtcgaac gcgcagaacc gggtcgccac gccgacccgt gtgcccaggt
2871541 ccaccagccg ggccgccttg tccgagttgc gcgccaccac ggtgatgtcg gtgaccccga
2871601 gttcggccag ccccaccacg gccgccggtg cggtcccccc ggaccccagc accagcgcgt
2871661 gtccagcagc cgcccccaac gccccggcca ccccgtcgat gtcggtgttg tcggcccgcc
2871721 agccatgcgg cgtccgaacc agggtgttgg ccgaaccgac aaggtccgcg cgtgcggtgc
2871781 gctcgtcggc gaaccgcagg gcggcgaact tgcccggcat ggtcaccgaa acaccgaccc
2871841 actccggtcc gaaaccaccg accacgacgg gcaactcggc cgcaccgcat tcgatgcgct
2871901 cataggtcca gtcgtgcagc cccaacgccc ggtaggcggc caggtgcagc tgcggggagc
2871961 gggaatgcgc gatcggcgaa ccaagcacgc cggctttttt gggaccttcg ctcatcgcgc
2872021 gctgtcgagg acaccgttgt gtttggccag ctcgatgttc gccagatgct gctgatagtc
2872081 cctggtgaac agcgtcgtgc cctgggaatc gatggtgacg aagtacagcc agtcgccagg
2872141 tactggatgc tcggcggcgc gcagcgcgtc gacgccgggc gaacagatcg cggtggccgg
2872201 cagcccctgg gccatgtagg tgttccacgg tgtgcgctgg gcacggtcgg tgtcgctggt
2872261 ggccacctca cggcgatcca gcggatagtt cacggtcgag tcgaactcca acgtgcggtg
2872321 ttcgtgcagc cggttgtaga tgacccgggc caccttcggg aaatcctggg tgttggcttc
2872381 ctgctgcacc agcgaggcca ccacgagaat gtcatagggc gacaggccca gcgactttgc
2872441 ggtgtctacc aacccggatt tcatgtactc cacggcgccg gcgctgatca aggtcgccaa
2872501 gatggtttca gccgatgccg acgggtcgat gttgaaggtc cccggtgcga tcagcccctc
2872561 gatccggcga tggtcagtgc ccagctccat caccggccca accgcccagc gcggcactga
2872621 cagcatcgtc ggcgtgctcc tgctcgccgc cgcgcggagg tcggccaccg agacgcagcg
2872681 ttgggtaccg tcgagatcca cacaggtggc acgggagatc agcgcgaata tgccaggatt
2872741 caccacgttg gtcttcatgt cggtggtgtc gtcgagctga cgcccttccg gtatgaccaa
2872801 cttccccacc cggttgtgcg gatcggtaag ccgcgcgaca gcggaagccg ccgaaatctc
2872861 ggttcgcatc cgatagaacc cgggttggat cgaggaaatc gcggtgttgc cgtgcgcggc
2872921 atcgacgaat gctcggacgg tggccactac accgtgtttg agcagcgtct ccccgaccgc
2872981 cgtggtcgag tcaccggccc tgatctgaat cacgatgtct cgcttgccgg gaccggtgta
2873041 gtcgttaccg aagcccaaca tggtctgcca caacttggcg ccgacgacga cggccaccac
2873101 caccaccacg acgagcaggc tcagggcaaa tccgccggcg acgcgccgtc gccggcggat
2873161 ttgttgggcg tgtcggcgct gagcgcggct gactcgggtc ctgcggtgcc ggttcggtct
2873221 taccgacacc ggctgggcgc ggtggcggtg gccaccgtca ggcatcggag ccttcttgag
2873281 tcccggccat cgccgcgaga cgttcatcca gccagctctg cagtattgcc actgcggccg
2873341 cttggtcgat caccgcacgc tgctcggagg cccgcacccc cgcctgccgc aaagatcgtt
2873401 gagcactgac cgtggtgagc cgctcgtcgg ccagccgcac cggcgtagga gaaacacggc
2873461 gtgccagcgc ctcggccagt tcgattgcgt cttgggccga gcggccgatg cggtcggcca
2873521 gcgtgcgcgg gagcccgacg atcacctcga ccgcctccaa ctcggcggcc agcgcagcca
2873581 gcctgcgcag gtgcttgccg gaacgatcgc ggcgcaccgt ttccaccggg gtggccaaga
2873641 tcgcgtccgg gtcgctgcaa gccacgccga tacgcgcggc gcccacgtcg ataccgaggc
2873701 gtcgtccccg tccagggtcg tgcgctggat cgccgggccg gtcgggcggg cggtgctgtg
2873761 ctgggaccac tcaaccgacc cgcgctatca cggcgatctc ggagcggacc gcgtcgagcg
2873821 cggcgtcgat accggtcgga ttctttcccg agccctgcgc caggtccgcc ttaccgccac
2873881 cgcggccttc gaccgccacc gcaagttgtt tgaccaggtc gttggcacgg attccgaggt
2873941 cctgggcagc gggattggcc gcgaccgcat acggcacagt ttggctttcg ccctcggcaa
2874001 tcagcgccac caccgccggc tcgctaccca gcttgccgcg gatgtcgccg atcaacgacc
2874061 gcaggtctgc cgcggtcatc ccgccggaca ttcgctgcgc caccaaacgg acgttaccga
2874121 tccgctgagc cccggcggcg gcattggtgg cggctgcccg ggcgctggcc atccggacac
2874181 gttcgagttc cttctcggcg gcccgcaggc gctccactag attggccacc cgggccggta
2874241 cctcttcgga cggcaccttc agtgacgagg ccaacccggc catcaacgca cgctccttgg
2874301 ccaggtgacg aaacgaatcc aaccccacgt aggcctccac ccggcgcacc ccggagccga
2874361 tcgacgactc gcccaggatc gtcacgggac cgatctgcgc cgtgttgctc acatgggtgc
2874421 cgccacatag ctccagcgag aacggtccac ccatctccac cacccgcact tcgtcggggt
2874481 agctctcgcc gaacagcgcg atggcaccca tcgccttggc cttgtcgagc tgttcggtga
2874541 acgtgcgcac ctcgaagtcc gcttgcacgg cctcgttggt gacctcttcg acctgggtgc
2874601 gctggtcgtc ggtcaacgga ccctgccagt taaagtcgaa gcgcaaatat cccggccggt
2874661 tcagcgatcc cgcctgaacc gcgttgggcc ccagcacttg tcgcagcgcg gcatgcacca
2874721 tgtgggtgcc cgagtggccc tgcgtggcac cccggcgcca cccgggatcc accgccgcga
2874781 ttacggtgtc accctcgacg aattccccgg attccacgtt gactcggtgc acccaaagcg
2874841 ttttggcgat cttctgcacg tcggtaaccg cggcccgggc agcttcgctg gaaccggttc
2874901 cgctgatggt gccctcatcg gcgatctgcc cacccgattc ggcgtagagc ggggtgcgat
2874961 ctaagacaag ttcgacacgc tgcccttccc cggctccgcc ggctacaccg tgcgccacca
2875021 ccggaacccg cttaccgtcg acgaagatgc ccagaatccg cgcctgggaa cgcaactcgt
2875081 cgaatccggt gaactcggtg gcgccggcgt caaccagctc gcggtaggcg ctcaggtcag
2875141 catgcgcgtg tttgcgcgcg gcggcgtcgg ccttggcacg gcggcgctgc tcggccatca
2875201 gctcacggaa cccgatttcg tctacctgca gaccggtttc ggccgccatc tccagcgtga
2875261 gctcgatcgg gaacccgtag gtgtcatgca acgtgaaagc gtccgatccg gacagcacgg
2875321 tggctccgga tttcttggtg gagctagcca cctcctcgaa cagcctggaa cccgacgcca
2875381 gcgtgcggtt gaacgccgtc tcctcggcga ccgcgatccg gctgatccgc tcgaagtcgg
2875441 cgacgagttc gggatatgac gggcccatcg cgttgcgcac cgtggccatc aggtcgccaa
2875501 cgatcgcagc gtcgatgccc agcagcttgg cggagcggat cacccgacgc agcagccggc
2875561 gcagcacata accgcgaccg tcgttgccgg ggctgacgcc gtcaccgatc aggatcgcgg
2875621 cggtgcggct gtggtctgcg atgatgcggt accgcacgtc gtcttcgtgg ttgccgacgt
2875681 cgtaggcacg cgcggcgacc ctggccacgg tatcgatgac cggcctgagc aggtcggtct
2875741 cgtagacgtt gtgcacgtct tgcagcacca gcgcgatccg ctcgacgccc atgccggtgt
2875801 cgatgttctt gcggggcagc ggcccgagga tctggtagtc ctccttggtg gttccctctc
2875861 cgcgctcgtt ctgcatgaac accaggttcc agacctcgag gtagcggtct tcgctgacga
2875921 tgggaccgcc tgcgggaccg aattcgggtc cgcggtcgta atagatctcc gatgacggcc
2875981 cgcacggtcc gggaatgccc atcgaccagt agttgtcggc catgccgcgg cgctggattc
2876041 gctccgccgg cagcccggca acctcctgcc atagccggac agcttcgtcg tcgtcgaaat
2876101 agactgtcgt ccagattctt tccgggtcca ggccgtagcc gccggcggcg aggctgttgg
2876161 tcagcagtgc ccaggccagt tcaatggccc cgcgtttgaa atagtcgccg aagctgaaat
2876221 tgccggccat ctgaaaaaac gtgttgtgcc gggtggttat gcccacctcg tcgatatcgg
2876281 gggtacggat gcacttctgg atgctggtgg ccgtcgggta cggcggcgtg cgctgtccca
2876341 agaagaaagg cacgaactgg accatcccgg cgttgacgaa caacaggttg gggtcgtcga
2876401 ggatcaccga ggcgctgggc acctcggtgt ggcccgcctt cacgaaatga tcgaggaacc
2876461 gcttcctgat ctcgtgtgtc tgcactctac gttcttcctt gatccgtggt taagtccatt
2876521 accagcctat tcgccggatt atgagaaggc tgtccgacgg cccaattcgg cccgctcagc
2876581 cttccacaaa gctcaatcgc accgaccgcc gcggattgtc ctggttgagg tcgaccagaa
2876641 cgatgctttg ccaggtgccc agcaggggct ggccccccga gaccggcacc gtcaccgacg
2876701 gcgcaacaaa agccggtaac aagtggtcgg cgccgtgacc gtaggacccg tgcgcgtgcc
2876761 ggtagcggtc gtcgcgcggc aacaaccgca ccagcgtgtc caccagatcc tcgtcggaac
2876821 cggcgccggt ctcgataatc gcaacgccgg ccgtagcgtg cgggacgaac acgttgcaca
2876881 ggccatcatc atgggcggtg cagaaggcgc gcacggcgtc ggtgagatcg acaatgcggc
2876941 gacgcgcggt gtccacatcc agcacatcgg tatccacccg tcccagccta cggtgggggc
2877001 gcgccaacct gccaatccat tgacgtcgga ttgcccattg ccccggccgg cccgtcggag
2877061 gaaggtaatg attgaccggt ggcgccaccg gggcgctgcc ccgaacaatg aaagaggggt
2877121 ggatcgtgta cgcgcgctct accactattc aggcgcaatc cgagtgcatc gacaccggaa
2877181 ttgcgcacgt tcgcgatgtg gttatgcccg cactgcaggg gatggatggg tgcatcggcg
2877241 tatccctttt ggtcgaccgg caatccggca ggtgcatcgc caccagtgcc tgggagaccg
2877301 cggaagccat gcatgcaagc cgggaacagg taacgccgat ccgcgatcgg tgcgcggaga
2877361 tgttcggcgg cacgccggcc gtcgaggagt gggagatcgc ggcgatgcat cgcgaccacc
2877421 gctcggccga gggggcgtgt gtgcgggcga cctgggtcaa ggtgccggcg gaccaagtag
2877481 atcaaggcat cgagtactac aagtcgtccg tcctgcccca aatcgaaggc ctcgacggat
2877541 tctgcagcgc cagcctgttg gtcgaccgca cctccgggcg cgcggtgtct tccgcgacct
2877601 tcgacagctt tgacgccatg gagcgcaacc gggaccagtc gaatgcgctc aaggccacat
2877661 cgctgcgtga ggcgggcggc gaggaactcg atgaatgcga gttcgagctg gcgctagcgc
2877721 acctacgggt acccgagctg gtctgatcaa cccgccggcg gcagtaccgg cccgagcccg
2877781 acgctgggcc ggcactgctg tcgtgcgtcg agcggcgctc gcggtaggca ttgccaggct
2877841 cagccggttg gaggaaggta tttggtggga ccggtggcgc caccggggcg ctgccccgac
2877901 acgggagggg gtcgatcgtg tacgcacgct caaccaccat tgaggcgcaa cctctgtcgg
2877961 tcgacattgg aatcgcgcat gttcgtgacg tcgtcatgcc cgctttgcag gagatcgacg
2878021 ggtgtgtcgg ggtgtcgctg ttggtcgacc ggcaatccgg ccggtgcatc gccaccagcg
2878081 cctgggagac cttggaggcg atgcgcgcca gcgtcgagcg ggtggcaccc atccgcgacc
2878141 gcgccgcgct gatgttcgcc ggtagtgccc gggtcgagga atgggacatc gccctgttgc
2878201 accgcgacca cccgtcgcat gagggggcat gcgtgcgcgc cacctggctc aaagtggtgc
2878261 cagaccagct cggtcggtcc ctggagttct accgcacgtc cgtacttccc gagctggaga
2878321 gtctggacgg gttctgcagc gccagcctga tggtcgacca ccccgcttgc cggcgtgcgg
2878381 tgtcgtgctc gacgttcgac agcatggacg cgatggcccg caaccgcgac cgggcgagcg
2878441 agctgcgcag caggcgcgtc cgggaattgg gagccgaggt cctcgacgtc gccgaattcg
2878501 aactggcgat cgcacatcta cgggtacccg agctggtctg agcggacctg cttcccgcag
2878561 agcgcagcgg tcacccccgt ttcttgcgga tgattgcccg caggcggtcc aggcggccgg
2878621 cgatctcgcg ttcgccgccg cgaccagtgg gccggtagta gtccacgtcc accaactcgt
2878681 cgggcgggta ttgctgggcc acaacgccat ccgggtcgtc atgggaatat ttgtagccct
2878741 gtgcattgcc cagcgccgcc gccccggagt aatgcccgtc acgcagatga gccggcacca
2878801 gaccggcctt gccggccttg atgtcgttca tcgccgcggc caacgccgtg gtgacggcgt
2878861 ttgacttcgg tgcggtggcc aggtggatgg tggcgtgcgc cagcgtcagc tgggcttcgg
2878921 gcatgccgat cagcgccacc gtctgtgcgg cggcgaccgc cacctgcagc gcgctcgggc
2878981 cggccatgcc gatgtcctcg ctggccagaa tcatcagccg gcgggcgatg aaccgcgggt
2879041 cctccccggc gaccagcatg cgggccaaat agtgcagcgc ggcatcgacg tcggaaccgc
2879101 gcaccgattt gatgaaggcg ctgacgacgt cgtagtgctg gtcgccgtca cggtcgtagc
2879161 gcaccgcggc tttgtccacc gaccgctcga tggtttgcac gctgaccagc tcgccggccg
2879221 cctgggctgc ctcggccgct acttccagcg cggtcagggc gcgccgggcg tcgccggccg
2879281 cgagttgcac cagcaggtcg acggcctcag gcgctaccgc gactgccctg cccaggccgc
2879341 gggggtcatc gatcgcgcgt tgtactaccg cgcgggtgtc ctcggccgtc agcggccgca
2879401 gctgcaggat cagcgaccgc gacagcagcg gtgccaccac cgaaaacgac gggttctcgg
2879461 tggtcgccgc caccaacagc accacccggt gttccaccgc cgacagcagg gcgtcttgtt
2879521 gggtcttgga aaatcggtgc acctcgtcga tgaacagcac ggtctgctcg ccgtgaagca
2879581 gcgcttttcg cgaattctcg atgaccgccc gcacttcctt gacgccggcc gacaatgccg
2879641 acagggcctc gaaccggcgg ccggtggcct gcgagatcaa cgccgccagc gttgtcttgc
2879701 cgctgcccgg gggaccgtag aggatcaccg acgccacccc cgagccctcg accagccggc
2879761 gcaacggcga accgggcgcc agcaagtggt cctggccgac cacttcgtcc agcgacgccg
2879821 gacgcatccg caccgccagc ggtgccccgg ccgaagcgcc caggtcatgg ccggacgtca
2879881 tcggtacgcc gggcacgtca aacagaccgt cggacacggc ttcaggcata ccacgcccac
2879941 ctgacgacgc gaacgttcgc cgaagacgcc acacgaataa tccgcgcgcc ttcggcaaat
2880001 atttgctaag ttccggtttg cttagcgtcg cgcgggtacc gataaaagcg aactacgaag
2880061 cgattgggac agcgatgagc cagccgccag aacatccagg caatccggcc gacccccagg
2880121 gcggcaatca gggcgctgga agctacccgc cgcccggcta cggagcgcct cccccgccac
2880181 caggctacgg cccacccccg gggacctacc tgcctcccgg ctacaacgca cccccgccgc
2880241 cccccggcta tggcccaccg ccgggcccgc cgcctcccgg ttacccgacg catctgcaat
2880301 cgtcgggttt tagcgtgggc gacgcgatca gttggtcatg gaataggttc acgcagaacg
2880361 ccgtaacgct cgtcgtcccg gtgctcgcct acgctgtggc gttggccgcg gtcatcggcg
2880421 cgacggccgg gctcgttgtc gccctatcgg accgtgctac taccgcatac accaacacct
2880481 ccggcgtctc tagcgaatcc gtggacatca cgatgacccc ggccgcgggc atagtcatgt
2880541 tcctcggcta catcgctcta ttcgccctgg tgctctacat gcacgccgga attctgaccg
2880601 gctgccttga cattgccgac ggaaagccgg tgaccatcgc gacgttcttt aggccgcgca
2880661 atctgggcct ggtgctggtc accggactgc tgatcgtcgc cgtcaccttc attggtggcc
2880721 tgctctgtgt cattcccggc ctgatctttg gcttcgtcgc ccagttcgcc gtcgcttttg
2880781 ccgtcgaccg ttccacttcg ccgatcgact cggtaaaggc cagcatcgag acggtcgggt
2880841 ccaacatcgg tggcagtgtg ctgtcgtggc tcgctcagct cacggcggtg ctcgtcggcg
2880901 aactgctgtg ctttgtcggc atgctgatcg gcattccggt cgccgcgctc atccacgtct
2880961 acacctaccg gaagctgtcg ggtggccaag tcgttgaggc agtccggcca gcgcccccgg
2881021 tcggctggcc gcccggcccc cagctcgcat agtcggcacc cgccgacgcc ggctggccgt
2881081 cttggcccgc tggatttgtc acgcgctcac ccgaattggc atccggggcc tggaacgcgt
2881141 tagggcagtg gctttcccac aggttgacgt aaatgacctc caagataggt atcgaaccaa
2881201 ggttgcggcc gatgtgtacg tagttcgaga gttcgctgat ctgatcactc gcgtggtcga
2881261 tgcagtcgac ggaaccggca gccgccaccc aagggtgcgc aggtggttag caaatcgccg
2881321 acgaacacga cgccaccgcg tcatgcgcca tcgccgaccc cgccttggtg gctgagagcc
2881381 gctcgccggc gttaagctgc ccaacatcat gggcattcaa cgcgccgttc tcctcattgc
2881441 cgacatcggc ggatacacaa attacatgca ctggaaccgc aagcacctgg cccacgcgca
2881501 gtggacggtg gcacagttgc tggagtccgt catcgacgct gccaagggca tgaagttggc
2881561 gaagctggag ggcgacgccg cgtttttttg ggcaccaggg gggcaacacc agtgtcctgg
2881621 tatgcgaccg gcccccgcag atgcgccaga ggttccgcac gcggcgcgag cagatcaaaa
2881681 aagaccatcc ctgcgactgt aagagttgcg agcagcggga caacctgtcg atcaaattcg
2881741 tcgcccatga gggcgaagtg gccgaacaaa aggtgaagcg caacgtcgaa ctcgctggcg
2881801 ttgatgtcat cctggtgcac cgcatgctga aaaatgaggt gccagtgtcg gaatatctat
2881861 tcatgaccga cgtcgtagcg cagtgcctcg acgagtcggt gcgaaaacta gcgacgccgc
2881921 tgacacatga cttcgagggc atcggagaaa cgtcgacaca ctacatcgac ctcgccacgt
2881981 ccgacatgcc gccggcggtg ccagaccaca gcttcttcgg cctgctgtgg gcggatgtga
2882041 agttcgaatg gcacgcgtta ccgtacctgt taggtttcaa gaaggcctgt gcaggtttcc
2882101 gcagcctggg ccgcggcgcc accgaagagc ccgccgaaat gggctaatcg ggttcgcttg
2882161 gctcgatcgc cgatgatctc gaccgccacg accgaccccc tcacctcggt cgaacctcgg
2882221 cgaaccaacg cggcaacgcc agcccatgat catttgattg ggtccacgga agcaggtagc
2882281 ttccgtcgca tgctttttgc ggctttgcgt gatgtccaat ggcgaaaacg acgccttgtc
2882341 atcgcaatcg tcagcaccgg cctagttttc gcgatgacgc tcgttctgac cggacttgtg
2882401 aacgggtttc gggtcgaggc cgagcgaacc gtcgattcca tgggtgtcga cgcattcgtg
2882461 gtcaaggccg gcgcggcagg accgttcctg ggttcgacac cattcgccca aatcgacctg
2882521 ccccaggttg ctcgtgcgcc tggcgtcttg gctgccgccc cactagcgac tgcgccgtcg
2882581 acgatccggc agggcacgtc agcgcgaaac gtcaccgcgt tcggggcacc agagcacgga
2882641 cccggcatgc cgcgggtctc ggacggtcgg gcgccatcga cgccggacga ggtcgcggtg
2882701 tcgagcacgc tgggccgaaa cctcggcgac gatctgcaag tgggtgcgcg cactttgcgg
2882761 atcgtcggca tcgtgcccga gtcaaccgcg ctggcaaaga ttcccaacat cttcctgacc
2882821 accgaaggcc tacagcagtt ggcatacaac ggacagccga caatcagttc gatcgggatc
2882881 gacgggatgc cccgacagct cccggacggc tatcagaccg tcaatcgagc ggatgctgtc
2882941 agcgatctga tgcgcccgtt gaaggtcgcg gtggatgcga tcacggttgt ggcggtcttg
2883001 ctgtggatcg ttgcggcgtt gatcgtcggc tcggtggtct acctctctgc gttggagcgg
2883061 ctgcgtgact ttgcggtgtt caaggcgatc ggcgtgccga cgcgctcgat tctggccggg
2883121 ctggcgctgc aggcggtcgt cgtcgcgctg ctcgcggcgg tggttggcgg catcctttcg
2883181 ctgctgttgg cgccgttgtt cccgatgact gtcgtggtac ccctgagtgc cttcgtggcg
2883241 ctaccggcga tcgcgactgt gatcggtctg ctggccagcg tcgcaggact gcggcgcgtg
2883301 gtggcgatcg atccggcact agcgttcgga ggtccctagc catgggcggc ctaaccattt
2883361 ccgacctggt cgtcgagtat tccagcggcg ggtacgccgt gcggccgatc gacgggttaa
2883421 gcctcgacgt ggcgccgggg tcgctggtga tcttgcttgg gcccagcggc tgcgggaaga
2883481 cgaccctctt gtcctgcctc ggcggcatcc tgcgcccgaa gtccggctca atcaagtttg
2883541 acgatgtcga catcacgacg ctggagggcg ccgcgctggc gaagtatcgg cgtgacaagg
2883601 tagggatcgt cttccaggcg ttcaacctgg tctcgagcct taccgccctg gagaacgtga
2883661 tggtcccgct gcgcgcggcc ggcgtgtcac gagcggccgc gcgtaagcgt gccgaggacc
2883721 tgctgatccg agtcaatctc ggcgaacgaa tgaaacaccg cccgggtgac atgagcggcg
2883781 gccagcagca acgcgtcgcg gtcgcccgcg cgatcgcgct ggacccgcaa ttgatccttg
2883841 ccgacgaacc gaccgcgcac ctggacttca tccaggtgga ggaggtgctg cggctgatcc
2883901 gctcgctagc gcagggcgac cgtgtggtgg tggtcgcgac ccacgacagc cggatgctgc
2883961 cgctggccga tcgcgtcctt gagctgatgc cggcgcaggt gtcgccgaat cagccacccg
2884021 aaacggtgca cgtgaaagcc ggcgaggtgc tgttcgagca gtccacaatg ggcgatctga
2884081 tctacgtggt gtccgagggc gagttcgaga ttgtgcgcga attggccgac ggcggtgagg
2884141 aattggtcaa aaccgccgcg cctggggact acttcggtga aatcggcgtg ctgtttcacc
2884201 tgccacgctc ggcaacggta cgggctcgca gcgacgcgac agccgtcggt tatacggcgc
2884261 aggcgtttcg ggagcggctg ggtgtgacgc gggtggccga cctgattgag caccgcgagc
2884321 ttgccagcga atagttcggc accaagtcgc gatccctgag ggttgcgatg ggcgcggcgc
2884381 cgccgctgaa tcgaccgccc cccactgagc cgccgtggaa tactcgatga atcctgcggg
2884441 cgtgtccgca ctgcgtgtgg ctatggagtt ggggaacatg ttgcttggga taagaacgtg
2884501 aatgagggac cgctcttcac aatgtcaggc actgccgtga gaagtccgct actcgatcgg
2884561 gtgtatgtga gcagtcctgg catgggccga gatgccaaga gccgcatctc atgaccaccg
2884621 cgcgacgacg gcccaagcgg cgtggtaccg atgcgcgaac cgcgctgcgc aacgttccga
2884681 tactcgccga tatcgacgac gaacagctcg aacgactcgc aaccaccgta gaacgccgcc
2884741 acgtgcccgc taaccagtgg ctctttcatg ccggagaacc agcggactcc atctatatcg
2884801 tcgactcggg gcggttcgtc gctgttgccc cagagggaca cgtatttgct gagatggcat
2884861 ccggcgactc gatcggagac ctgggggtga tcgccggggc tgcccgctca gcgggagtgc
2884921 gagctctgcg agacggcgtg gtgtggagga tcgccgcgga gacgtttacc gacatgctcg
2884981 aggcaacccc gctactgcaa tcggcgatgc tgcgagcgat ggcgagaatg ctacgccagt
2885041 cacgacccgc caagacggct cggcgtccgc gggtcatcgg cgtggtatcg aacggggaca
2885101 ccgccgcggc cccgatggtc gacgcgatcg ctacttcact ggactcgcac ggtcgaactg
2885161 ccgtgattgc gccgcccgtc gaaaccacct ccgccgttca ggagtacgac gagctcgtcg
2885221 aggcgttcag cgaaaccctc gatcgcgcgg agcgaagcaa cgattgggtc ttggtggtcg
2885281 ccgaccgagg cgccggcgac ctgtggcggc actacgttag cgcgcaaagc gaccgactcg
2885341 tggtcctggt ggatcaacgg tatccgccgg atgcggtcga ttcgcttgct acccaacggc
2885401 cagtgcacct gatcacatgt ctggcagaac cggatccaag ttggtgggat cggttggcgc
2885461 cggtttcgca tcatccggcc aactccgacg gcttcggtgc ccttgctcgc agaatcgccg
2885521 gccgatcgct cggcctggtg atggccggtg gcggagcccg gggactggcg catttcggtg
2885581 tttaccaaga gctcaccgaa gccggcgtcg tcatcgatcg gtttggcgga acaagttcgg
2885641 gtgcaatcgc ttccgcagcg ttcgcgctgg ggatggacgc cggggatgcg atcgccgcgg
2885701 cgcgagagtt catcgcagga agcgacccac tcggcgacta cacgatccca atatccgccc
2885761 tcacgcgagg tggacgcgtc gatcgtctgg tgcagggatt cttcggcaac acgttgatcg
2885821 aacatctgcc cagagggttc ttctccgtct ccgccgacat gatcaccggc gatcagatca
2885881 tccatcggcg gggatccgtc tcgggcgccg tgcgcgcatc gatctcgatc cccggtctca
2885941 tcccgccagt gcacaatggc gagcagctgc tcgtcgacgg tgggctgttg aacaatctgc
2886001 cggccaacgt gatgtgcgcc gataccgatg gcgaagtcat ctgcgtcgac ctccgccgaa
2886061 cgttcgtgcc gtcgaagggc tttggcctgc tgccgccaat cgttacgccg cccgggctcc
2886121 tccggcggct tttgaccggc acggataacg cgctaccacc gctgcaagag acgttgctgc
2886181 gcgccttcga ccttgccgcc tccaccgcaa acctgcgcga gcttcctcgc gttgcggcca
2886241 tcatcgagcc cgacgtgtcg aagatcggag tgttgaactt caagcagatt gatgccgccc
2886301 tagaggctgg gcggatggca gcccgtgcgg ctttgcaagc acagccggac ctggtgcgct
2886361 gaacccgacc aagtgccgct acggcccact caggtgtccg gcaccgggcg tacgcgctgc
2886421 gccgggcggt ccggtgtgat ctcatcagca gctatgagca tcaaagttgc gctggagcac
2886481 cgcaccagct acacctttga ccggctggtg cgggtgtatc cgcacatcgt gcggctacgc
2886541 ccggcgccgc actcccgcac ctccatcgaa gcctactcgc tgcgcatcga gcccgccgac
2886601 cacttcatca actggcagca ggacgcgctg ggcaactttc tggcgcggct ggtctttccg
2886661 aatcccatgc gccaactgcg tattaccgtc gggcttatcg ccgacctcaa ggtgatcaac
2886721 cccttcgact tctttatcga ggactgggcc gagatatggc cctgcgcagg gatggcctac
2886781 cccaaggcgc tcgccgatga cctgaggccg tacttgcggc cggtcgacga agacggcgac
2886841 ggttcgggcc ccggcgagct cacgcaggcc tgggtgcgca acttcacggt gcccgatggc
2886901 acccgcacca tcgacttctt ggtcgcactc aaccgcgcga tcaacgccga cgtcggctac
2886961 tgcgtgcgca tggagcccgg agttcagaca ccggatttca cgctgcgcac cggcgtcggc
2887021 tcgtgccggg actcggcgtg gctgctggtc tcgatcctgc gtcagttcgg gctggccgcc
2887081 cggttcgtgt ccggctacct ggttcagctg gcatccgaca tcgaagcgct cgacgggccg
2887141 tcggggcccg ccgccgactt caccgacctg cacgcgtggg ccgaggcata catcccgggt
2887201 gccggctgga tcgggctgga cccgacgtcg gggctgttgg ccggcgaggg ccacattccg
2887261 ctggcggcta cgccccaccc cgccagcgcg gcacccatca gcggcggcac cgacgtgtgc
2887321 gacaccgtgc tggagttctc caacaccgtc acccgcgtac acgaagaccc acgtgtcacg
2887381 ttgccctaca ccgacgagtc ctggaagacc atctgtgagg tgggccagcg cgtcgatgag
2887441 cggctggccg ccgccgacgt ccggctgacc gtcggcggcg aaccgacgtt cgtgtcggtg
2887501 gataaccagg tcgccgaaga gtggcggacg gcggccgacg gcccacacaa acgcgaacgg
2887561 gcatccgacc tggccgcccg cttgaaggcg gtgtgggccc cgcagggact catccaccgc
2887621 ggtcagggca ggtggtatcc cggagagccg ttgccgcgct ggcagattgc gctgtattgg
2887681 cgcaccgacg ggcggccgct gtggaccaac gacgcgctgt tggccgaccc ctggggcgcc
2887741 ccgcccgccg accccgtcga cgacgacgcg gcctaccggg tgctcgccgg gatcgccgac
2887801 ggcttggggc tgccgatctc gcaggtgcgg cccgcctacg aagacccgtt gagccggctg
2887861 gctgcggccg tgcgaatgcc agccggcgac ccggtggaat ccggtgacga cctcggctgc
2887921 gacaccaacc ccgacacccc caccggccgc gccgcgctgc tggcgcgcct cgatgaggcc
2887981 atcacctctc cggctgcgta cgtgctgccg ctgcaccgcc gcgacgacgg gcaaggctgg
2888041 gccagcgcga actggcggct gcgccgcggt cgcatcgtgt tgctcgaagg ggattcgccg
2888101 gcgggcctgc ggctgccgct ggattcgatc agctggcgcc caccccgggc atcgtttgac
2888161 gccgacccgg tagctgtgcg atccacattg ccggcggagc tccacaccga ccgggccgta
2888221 gtggaggatc ccgagacggc tccgaccacc gcgttggtcg ccgaggtccg gggtgggctg
2888281 gtgcacatct tcttgccgcc caccgacgcg ctcgagcact tcatcgacct tgtcgcccga
2888341 gtcgaggccg cggcgacgac ggccaactgc ccggtggtga tcgagggcta cggcccaccc
2888401 ccggacccgc ggctgacgtc caccacaatc acccccgacc ccggcgtcat cgaggtcaac
2888461 atcgcgccca ccgcctcttt tgcagaacaa cggcaacagc tggaaaccct gtatcaacaa
2888521 gcgcgcctgg cccgactcac caccgaagcg ttcgacgtcg acggcacgca cggcggcacc
2888581 ggcggcggca accacatcac gcttggcggc gtcacacccg cggactcacc gctgctgcgc
2888641 cggcccgacc tgctggtttc actgctgacc tactggcagc gacacccgtc gttgtcctac
2888701 ttgttcgccg ggcgtttcgt cggcaccacg tcacaggcgc cccgggttga cgagggccgc
2888761 gccgaggcgc tctacgaact cgagatcgcg ttcgccgaga tcctccggct gtcgccgtcg
2888821 tccgggggcg gccggcccca accgtgggtg accgaccgcg cgctgcggca cctgctcacc
2888881 gacatcaccg gcaacaccca tcgcgccgaa ttctgcatcg acaagctcta cagccccgac
2888941 agcgcccggg gcaggctcgg cctgctggag ctccgcgggt tcgagatgcc gccgcacctg
2889001 cacatggcga tggtgcagtc gctgctggtg cgctcgctgg tggcgtggtt ctgggaccaa
2889061 ccgctgcgcg ccccgctgat ccgccacggc gccaacttgc acggtcgata tctattgccg
2889121 cacttcttga ttcatgacat cgccgacgtc gcagccgacc tgcgcgcgca cggcatcgcg
2889181 ttcgagacta gctggctgga cccgttcacc gagttccgct tcccgcgcat cggcaccgcc
2889241 gtattcgacg gcattgagat cgagctgcgc ggggccatcg agccatggca cacccttggc
2889301 gaggaggcca ccgcggcagg caccgcgcgc tatgtcgact cgtcggtcga gcgcatccag
2889361 gtccgcatca tcggcgccga ccggcaccgc tacgtggtga cctgtaacgg ctacccgatg
2889421 ccgttgctgg ctaccgacaa ccccgacatc cacgtgggtg gtgtgcggtt caaagcgtgg
2889481 cagccgccca gcgcgctaca cccgaccatc acggtcgacg gcccgttgcg gttcgagctc
2889541 atcgacatcg ccaccgctac ctcgtgcggc ggctgtacct accatgtcgc ccatccgggc
2889601 ggccgcgcct acgacgagcc cccggtcaac gctgtggagg cggaggcccg ccgcgcccgg
2889661 cgcttcgagg cgaccggctt caccccgggc aagctcgacc tgtccgacat ccgggagaaa
2889721 caggccagga tatccaccga tatcggcgcg ccgggcatcc tcgacctacg acgcgtgcgt
2889781 accgtgcaac agtaatggca ccctcagctt ctgccgctac caacggctac gacgtcgacc
2889841 gcctgctggc cggataccgc accgcgcgtg cccaggaaac actgttcgac ctgcgggacg
2889901 gcccgggagc cggctatgac gaattcgtcg acgacgacgg caacgtgcga ccgacctgga
2889961 ccgagctcgc cgacgcggtc gccgaacgtg gcaaggcggg gctggaccgg ctgcgctcgg
2890021 tggtgcacag cctgatcgac cacgacggca tcacctacac cgcaatcgat gcacaccggg
2890081 acgcgctgac cggcgaccat gatctggaac cggggccgtg gcgcctggac ccgctgccgc
2890141 tggtgatttc cgcggccgat tgggaagtgc tggaggccgg cttggtgcag cgatcgcgct
2890201 tgcttgatgc catcctcgcg gacttgtacg ggccccgcag catgctcacc gagggtgtcc
2890261 tgccgccaga gatgctgttc gctcatcccg gctacgtgcg tgccgctaac gggatccaga
2890321 tgcctgggcg ccaccaactt ttcatgcacg cctgtgatct cagccggttg cccgacggga
2890381 cttttcaggt caacgccgac tggacgcagg cgccctcggg ctccggctat gcgatggccg
2890441 atcgacgtgt cgtcgcgcac gccgttcccg atctgtacga ggaactggcg ccgcgaccca
2890501 ccacaccgtt cgcccaggcg ctccggctgg cactgattga cgcggcaccc gatgtcgccc
2890561 aagaccccgt cgtggtggtg ctcagcccgg gcatctattc agaaaccgct ttcgaccagg
2890621 cgtatctcgc aacgctgctg ggtttcccgc tagtggaaag cgcggacctg gtggtgcgcg
2890681 acggcaagct gtggatgcgt tcgctgggca cgctgaaacg cgttgacgtc gttcttcgcc
2890741 gcgtcgatgc ccactacgcg gatccactgg atctacgcgc cgattccagg ctcggtgtcg
2890801 tcggtttggt ggaagcgcag caccgcggaa cagtgaccgt cgtcaacacg ctgggcagcg
2890861 gcatcctgga gaacccaggc ctgttgcgct tcctgccgca gctatccgag cgcctgctcg
2890921 acgaaagccc gctgctgcac accgctccgg tctactgggg cggcatcgcc agcgaacgct
2890981 cacacctact ggccaatgtc tcgtcgctgc tgatcaaaag cactgtcagc ggggaaactc
2891041 ttgtcggacc gacactttcg tctgcacaac tggccgatct ggcagtgcgt atcgaggcga
2891101 tgccgtggca gtgggtgggc caggagctgc cgcagttctc gtcggcgccc accaaccatg
2891161 ccggggtgtt gtcgtccgcc ggggtaggca tgcgactgtt caccgttgcc cagcgcagtg
2891221 gttacgcgcc gatgatcggc ggcctcggct atgtactggc gcccggccct gccgcatata
2891281 cgctgaaaac cgttgcagca aaagatatct gggtgcgccc aacggagcgt gcgcatgccg
2891341 aggtgataac ggtgccggtg ttggcgccgc cggccaaaac cggagcgggc acctgggcgg
2891401 tcagctctcc gcgcgtgctg tccgatctgt tctggatggg ccgctacggc gagcgcgcgg
2891461 agaacatggc ccggctgctg atcgtcaccc gcgagcgcta ccacgttttc cggcaccagc
2891521 aggacaccga tgaaagcgag tgcgtgccgg tgctgatggc cgcgctgggc aagatcaccg
2891581 gatatgacac cgcaactggc gccggcagcg cttacgaccg ggccgacatg atcgcggtcg
2891641 ccccgtcgac actgtggtct ttgaccgtgg atccggaccg gccgggttcc cttgttcagt
2891701 cggtggaggg gctggcactt gccgcccagg cggtgcgcga ccagctgtcc aacgacacct
2891761 ggatggtgct ggccaatgtg gaacgcgcgg tggagcacaa gtccgacccg ccgcagtcgc
2891821 tggcagaggc ggacgccgtg cttgcgtcgg ctcaggcgga gacgctagcc ggcatgctga
2891881 cgttgtccgg ggtggccggc gagtcgatgg tgcacgacgt gggctggacg atgatggaca
2891941 tcggcaagcg tatcgaacgc ggcctgtggc tgaccgcgtt gctacaagcc acgttgagca
2892001 ccgtgcgcca ccccgccgcc gagcaagcca tcatcgaggc aaccctggtg gcgtgtgaat
2892061 cgtcggttat ctatcggcgc cgcaccgtag gcaagttcag tgtcgccgct gtgaccgagc
2892121 tgatgttgtt cgacgcccag aacccgcgct cgctggtgta tcagctggaa cggctgcgcg
2892181 ccgacctgaa agacctgcct ggctcgtcgg gatcgtctcg tccggaacgg atggtggacg
2892241 agatgaacac ccgcctgcgc cgctcacacc cagaagagtt ggaagaggtc tccgccgacg
2892301 ggctgcgcgc cgagttggcg gaactgctgg ccgggataca tgcctcgctg cgtgacgtgg
2892361 ccgacgtcct caccgccact cagttggcgt tgcccggcgg catgcaaccg ctgtggggtc
2892421 cagaccaacg gcgggtgatg ccggcctaaa cggtgcgacg gctgtgagcc ggctcgaaat
2892481 ccggggccac ctcgtcgacg acggtgtgga tgaaccgcat cttctccagc acagcggccg
2892541 gcagcacaaa ggggtatagg tcgtcgtggc ccatcgagcg attgaccatg ttcagcgacc
2892601 acgacagcgg cagccacttg tcgatgatgg tattaaaagc gctggggccc aacgccggcc
2892661 ggtcgaaggt tgccgacgcc ggtgccaggc cgcaccaggc cgcggtgtcc agggcgtcgc
2892721 ggatatgcag gtaatgagcg aacgtctcgg cccaatcctc actcgcgtgc atggtcgcat
2892781 acgacgagac aaagctgtcc tgccaacctt ccggcgggcc gccacggtaa tgccgatcca
2892841 acgcctggga gtagtcagcg tccgggtctc cgaacaactc gttgaaccgg gacagatagt
2892901 cgcttgacga ggcgatgagt cgatagaagt agtagtgccc gatctcgtgg cggaagtgcc
2892961 caagcagggt ccgatacggc tcgtccatct cgacccgcag ctgctcccga tgcacatcgt
2893021 cgccttcggc gagatccagt gtgatgactc cgttctggtg tccggtggtc acgttctcgt
2893081 gcgcgctgga caatagccgg aaggccaacc catggtcagg atcctggtcg cggccgacga
2893141 tcggcagctt cagctcgtgt agctcggcga tcagccgccg cttggcacct tcggctcggg
2893201 cgaactccgc cagcccggcg gtgttggtat cgctgggccg ctcgatggtc agcacacaag
2893261 aactgcaaag tccgccgagc tgatcactgg gcaccagcca attgcattgc gcgaggtgga
2893321 gattggcgca gagttggaca tcggcgtcgt cggcgatgac cagcagcgcc atccgcccaa
2893381 gagaaaaccc cagcgcgctg ccgcacgaca ggcaggcgga gttctcgaat gccaggcgct
2893441 gcccgcaatt tggacagtgg aagtcacgca tgcagcgcat caccttcgaa gggcacgaca
2893501 tcgacagaaa cgtcgatcac actgttctcg gagttggtgt agatgatgcc gcgtagcggc
2893561 ggcacgtctg cgtagtcgcg gccgcggccc acgacgatgt agcgctggtc gaccaactgg
2893621 tcattggtgg gatccagccc cagccactcg aaccgcccgg gctgctgcgg agtccacacc
2893681 gaggcccagg catgcgtcgc gtcgatgccg atcatccgat cctttccggg cggcgggtcg
2893741 gtggccaggt agcccgacac ataacaggcc gccaaaccgt tggcccgtag gcaggcgatc
2893801 gccagcctgg cgaaatcttg gcatacccct tcgcgggcca gcagcacctc gttgactcct
2893861 gtggaaatcg tcgtggaacc cgagcggtag gtgaagtcgg tgtagatccg cgacgcgaga
2893921 tcgcgcaata cctcgaccag ggggcgtttg ggcaggaagc taggagccgc gtactcacgc
2893981 accgcatcgg tgatctccgg cgggttcaag tccagggtga actcggtggc tagcgatccg
2894041 ggcagcccgg cgggccgggc cgcctcccac ggttgcagcg ccggcccgct ggtgtaaagc
2894101 ccgggcggcg gcggggacac gtcgacgatg gaatcgctgg tgatcgtcaa ggtgcggtgc
2894161 ggttcggtga cgtggaaata ggagctgatg ttgccgtacc cgtcgcggct ggtggaccgg
2894221 tcggcggggg ccgggtcgat ggtcagccgg tgtgcgacac aacgctgccg cagcgaattc
2894281 cgcggcgtga gaaacccgcg gccataggag ctggtcacca cgtcggagta gcggtattcg
2894341 gtgcggtgtg ttactcgata gcggtgagtg cccgacaacg gcaacgacaa cgagctatct
2894401 gctgacaaaa agctacctcc tggctgatca catcacacgc cggcggctcg tccggcgcga
2894461 tcgtcgcgca atgtggcgcc aagcgcacca tagccggagc acaattaaag cgtggctacc
2894521 tgggacgacg tcgcccgtat cgtgggtggg ctgccgctga ccgcggagca ggcaccgcac
2894581 gactggcgtg ttggccgcaa gctgctggcc tgggaacggc cgctgcgcaa gtccgaccgc
2894641 gaagccctga ccagggccgg atcggagcca ccgtccggcg acatcgtcgg tgtccgagtg
2894701 tcggacgagg gggtgaagtt cgccttgatt gccgacgagc cgggcgtgta cttcaccacc
2894761 ccgcatttcg acggctatcc agcggtgctg gtcaggctgg ccgagatcga ggttcgcgac
2894821 ctcgaggagt tgatcaccga ggcctggctg atgcaggcgc cgaagcagct ggtgcaggcg
2894881 tttctcgcca attcaggctg acatgcccga cgggcccggg cgttcgatta cccgttgtag
2894941 atcggtgaca cacgcttgga cgatatcggc gcgcaccact tcgttgctgc cacaagcagc
2895001 cgattgcagt gtcgacgcgg ttgcgcgggc ggcggccgcg tgctcgttcg ctgccgtcgg
2895061 atccgcgtcg gccaggccgg ttcccgcggc gaggtcggtg agcacggcgt gcacgggcgt
2895121 tggcagctta tcgccaccag gcccggcaat ggtgcgagcc agatgcaaca ccgaactgac
2895181 cagcagggcc aggtagacgg cctgttgatc gagatcgcgg acagtgctgc gcacccccca
2895241 tcggcggggc gctcgccgcg ccaccatggc agcgttggcg cgcacctcga tgagcccgtt
2895301 cagctgctga tgcagtcgat cagcggctgc catcggccag tcgggcgggg cgctggtggg
2895361 atcgctcacc gtgttcacca gctcggcgag gatgtcgcgc acagcggcca acacgtcggc
2895421 gcgcgcactg cacagcatga ccaccgggtc gggcgggaag agcagaatgc tgaacacgat
2895481 agccagccca ccaccgacca gcgcgtcgaa gaggcgttcg aaaaccacac tgccgttgga
2895541 cgcgaagacc aagaccagca ccgcggagac ggcggcctgg ttgatgaaca ttaagccttg
2895601 cgcgaccaac ccgcgtgcgc acagcaccgc gaccgacaac gcgatgaaca ccaccacacc
2895661 catggcgatc ggtccggaac caagcagagc atgcacgcca gcacccagca cgatccccag
2895721 cgccaccccg acgatcatct gttgggcacg tcgtgcgcgc agcacgttgg tcgccgacat
2895781 gcacaccaca gccgaaatcg gcgcgaagaa cgcctgcgga tggttgaaca cgtcatgggt
2895841 gagataccac gcgaggccgg cgacgaccga tgtctgggtg atcggccaca gcacggtgcg
2895901 caaccgttgg gcgaccgcac ggccgccgca ggccgtcctg actagcagcg aagcgctcat
2895961 gaacgcctat ttattcacac tcgggtgcga cgtcgtaacc gcaaagatct ggtcatgcct
2896021 gctggacccg cttgggctgg gcatctattc cggactcctt acgttgctga gcggtaatgg
2896081 gcgccggcgc gtcggtgagc ggatcgacgc cgccgccggt cttcgggaac gcgatcacct
2896141 cacggatcga gtccatcccg gccagcagcg cggtggtccg gtcccacccg aacgcgattc
2896201 cgccgtgcgg cggtgcgcca aacatgaacg cctccaacag gaatccgaac ttttcctccg
2896261 cctcggcctt gtccaggccc atcaccgcga acacccgttc ctggatatca cggcggtgga
2896321 tacgcaccga gccgccaccg atctcgtggc cgttgcagac gatgtcgtac gcgtcggcca
2896381 gcacgctgcc ggtatcggat tcgatgcggt cctcccattc cggtttcggc gcggtgaagg
2896441 catggtgcac cgcggtccag gcccccgagc cgaccgcgac ctcaccggcg gcggtcgctt
2896501 cgtcggccgg ctcgaacagc ggcgggtcaa cgacccagac gaatgcccac gcatcggggt
2896561 caatcaggcc cagccggttg gcgatctcga cgcgggccgc gcccagcagt gcccgcgacg
2896621 atttgaccgg accggccgag aagaagatgc aatcgccggg tttggccccg acatggtcgg
2896681 ccagtccggt gcgctcggcc tcggtcaggt ttttggccac cggaccgccc agcgtgccgt
2896741 cttcggcgac cagcacgtag gccagtccgc ggtggccgcg ctgcttggcc cagtcctgcc
2896801 agccgtccag cgtgcgccgc ggctgcgacg ccccgccagg catcaccacc gcgcccacat
2896861 acggtgcctg gaagacacga aatgtggtgt cggagaagaa atccgtgcat tcgacgagct
2896921 ccagcccgaa ccgcaggtcg ggtttgtccg taccgaatcg gcgcatcgct tcggcatagc
2896981 cgatccgcgg gatgggcgtc ggaatccggt agcctatcag cgcccacagc tcggtcagaa
2897041 cttcctcgga gatcgcgatg atgtcctcgg cgtcgacgaa gctcatctcc atatcgagct
2897101 gggtgaattc gggctggcgg tcggcgcgga agtcctcgtc gcggtagcag cgggcgatct
2897161 ggtagtagcg ttccatcccc gccaccatca gcagctgctt gaacagctgc gggctctgcg
2897221 gtagggcgta aaacgaaccg gggtgcagtc gggccggcac caggaagtcg cgcgctccct
2897281 ccggggtcga gcgggtgatc gtcggcgtct cgatctcgac gaagtcgtga cgcgccagca
2897341 ccgcgcgcgc agcggcattc acccgggaac gcagtcgaat cgccgcagcg gggtcgtcgc
2897401 ggcgcagatc gaggtagcgg tacttcagtc gcaactcctc acccgccggt tcgtccagct
2897461 gaaacggcag cggcgcacat tcgcccagca cggtcaacga cgtggcgttg acctcgatct
2897521 cgccggtggc gatctccggg ttggcgttgc cttccgggcg gatctcgacg acgccggcca
2897581 ccgatacgca gaattccgca cgcagccggt gagcctgcgc cagcacctca gtgtcctggg
2897641 ggtcgcggaa caccacctgt gcgatgcccg aagcgtcccg cagatcgatg aagatcacgc
2897701 cgccgtggtc gcggcggcga gccacccagc cggccaatgt cacctgctgc ccggcgtcgc
2897761 cttcccgtag caaacccgcg gcgtggctgc gcagcacaaa cactcccctt caaccggatt
2897821 aaccgactgc tcagtctaga ggtgcccgcg gcgcacatcg gtcacgcagg ataatttcgg
2897881 ctcatctcaa caaacattgc aacaggcatt gccctagtcg gacccggtgc cgtcggaacg
2897941 acggtcgccg cgctgttgca caaggccggg tattcgccgc tgttgtgcgg ccacactccg
2898001 cgcgccggga tcgagctccg gcgagacggc gcagacccca tcgtggtgcc cggtccggtg
2898061 cacaccagtc ctcgggaggt tgccggcccg gtcgatgtgc tgatcctggc ggtcaaggcc
2898121 actcagaacg acgccgcacg tccctggctg acccgcctgt gcgacgagcg caccgtggtg
2898181 gccgtgctgc aaaacggtgt cgaacaggtc gagcaggtcc agccgcattg tccgtcctcg
2898241 gccgtggttc ccgcgatcgt gtggtgttcg gccgagaccc agccgcaagg gtgggtgcgc
2898301 ttgcgcggtg aagccgcact ggtcgttccc accgggcccg cggccgagca gttcgccggg
2898361 ctgctgcgcg gtgccggcgc cacggtggac tgcgaccccg acttcaccac ggcggcctgg
2898421 cgcaaactac tggtcaacgc gctggcggga tttatggtgc tgtccggacg gcggtcggca
2898481 atgttccgcc gcgacgacgt cgcggcattg tcgcgccgct atgtcgccga atgcctggcg
2898541 gtggcgcgcg ctgagggtgc ccgactcgat gacgacgtcg tcgacgaagt ggtccgcctc
2898601 gtccggtcgg ccccgcagga catgggcacc tcgatgctgg ccgaccgggc agcccaccgg
2898661 ccactggaat gggatttgcg caatggggtg atcgtccgca aggcccgcgc ccacggcctg
2898721 gccaccccga tcagcgacgt gctggtgccg ctgctggcgg ctgccagcga cggtcccgga
2898781 tagcaatgta gctaatgtct agatcatgta cccctgcgag cgggtaggcc tgagcttcac
2898841 cgagaccgcg ccttacctct tccgcaacac cgtcgacctg gccatcacgc ccgagcaact
2898901 cttcgaagtg ctcgccgacc cgcaggcctg gccacgctgg gcaacggtga tcacaaaggt
2898961 gacctggacc agtcccgaac cgttcggcgc cggcaccacc cgcatcgtcg agatgcgcgg
2899021 gggtatcgtc ggcgacgaag agttcatttc gtgggagcct ttcacccgca tggcatttcg
2899081 gttcaacgaa tgctccacca gagccgtcgg cgcgttcgcc gaagactatc gggtgcaggc
2899141 catccccggt ggttgccggc tgacctggac catggcgcag aaactcgccg gcccggcgcg
2899201 gccggcgctg ttcgtcttcc ggcccctgct gaacctggcg ctgcgccggt ttctaaggaa
2899261 tctgcgcagg tataccgacg ctcggttcgc cgctgcgcag cagagttagg ctggatcggc
2899321 cgatttcggg agcgtgcgat gaccttcaac gagggtgtgc aaatcgatac cagcaccacg
2899381 tcgacctcgg gtagcggtgg cgggcggcgc ttggccatcg ggggcggcct cggtgggcta
2899441 ctggtggtgg tggtcgcaat gctgctcggc gtcgatcccg gtggcgtgct gagccaacaa
2899501 cctctcgaca cccgcgacca cgtagcaccc ggtttcgacc tgagccagtg cagaaccggg
2899561 gccgatgcca acaggttcgt gcagtgccgg gtggtggcca ccggtaactc cgtggacgcg
2899621 gtatggaaac cgctgttgcc cggctacacc cgcccacaca tgcggctgtt cagcggccag
2899681 gtaggcaccg gatgcggacc ggccagcagc gaggtcgggc cgttctactg cccagtggac
2899741 aaaacggcct acttcgacac cgacttcttc caggtgctgg tcacccaatt cggttccagt
2899801 ggcggcccat tcgcggaaga gtatgtggtg gcccatgaat acggccatca cgtgcagaac
2899861 ctgctggggg tgctcggccg cgctcagcag ggtgcgcaag gtgctgcggg cagtggcgtg
2899921 cgcacggagt tgcaggcgga ctgctacgcc ggggtgtggg catactacgc gtccaccgtc
2899981 aagcaggaga gcaccggtgt gccttacctg gagccgttga gcgacaagga catccaagac
2900041 gccctcgcgg ccgcggcagc ggtgggcgac gaccgtatcc aacagcagac gaccggacgc
2900101 accaaccccg agacctggac gcatggctcg gccgcgcaac ggcagaagtg gttcactgtc
2900161 ggataccaga ctggcgaccc caacatctgc gacacctttt ccgccgcgga cctggggtag
2900221 gcgaattacc agggacgagt cgagcactgc acgccgctgc cgccgtcctg cgacaccacc
2900281 acctggccgt ctacaacaat ctcgcagtgg aactccggat tgacccgcag gccgccgctg
2900341 gcggtgacga tcgcccactg gctcgggttt gccagcgtgg cggtatagac cagcggctga
2900401 ccgccagcga tcggagtgtg caaggtaatc atgtacttcg atgaatcggc attgaaagcc
2900461 gccatgctgg gcggatcggc gctcatgtac cgaatgttgg ccatcaggtc gctggtggtc
2900521 gtgacggtgt aggtcacctg atgcccgacc ggatccgcgc gggcaatcgc cgggatgacc
2900581 ccgctgagcg cggctccggc aaacgtcacc agcgcgacgg cgcttggcac tgtgcgcacg
2900641 gacgtcatat ctaaaacgct accggatgcg ttaccgacgc cggccggcac tgcatgcgat
2900701 gaccgtcgcc cgccatccgg gcaagccgaa ttgcgtgagc cgcaccgcca ttagcagccg
2900761 aaagctgtcg ttggcctcgg gcttcgcgct ctggaggcga tcgctggtgt gagcgtctac
2900821 gcagttcaga aagcctttcc gagcaacgcg ccgaggtaac ttcagatttc ggcagccggt
2900881 ttacccgcag gtaaaccagg gcgggtatga aacgtgagtg ggcgccgatc tgaagcagcc
2900941 gcaggatgcc gattcacccc cgaaaggggt tagccgccgt aggttcctga cgacgggcgc
2901001 ggcagcggtt gttgggacag gtgtcggcgc gggcgggacc gcgctgctgt cgtcacaccc
2901061 ccggggtcct gccgtctggt atcaacgtgg tcggagcggc gcgcctccgg tgggtggtct
2901121 gcacctgcag ttcggccgga atgccagcac cgaaatggtg gtgtcctggc ataccacgga
2901181 caccgtcggc aatccgcgag tcatgctggg cacgccaacc tctggcttcg gcagcgtcgt
2901241 ggtggccgag acccggtcgt accgggatgc gaagtccaat accgaggtgc gcgtcaacca
2901301 cgctcacctg accaacctga cacccgatac cgactacgtc tacgccgcgg tgcacgacgg
2901361 tacaactccg gagctcggga ccgcacggac cgcaccgtcg ggtcgaaaac cgctacgctt
2901421 caccagcttc ggtgatcagt ccactcccgc gttgggcaga ctggccgacg ggaggtacgt
2901481 cagcgacaac atcggatccc ccttcgccgg tgacatcacg attgcgatcg agcgtattgc
2901541 cccgttgttc aacctgatca acggtgacct gtgttacgcc aacctggcac aagaccgaat
2901601 tcgcacctgg tcggactggt ttgacaacaa cacccgctcg gcgcgctacc ggccgtggat
2901661 gccggcagcg ggcaatcacg agaacgaagt cggtaacggg ccaatcggtt atgacgccta
2901721 tcagacctac tttgcggtac ccgactcggg atccagcccg caactgcgcg ggctatggta
2901781 ctcgttcacc gccggctcgg tgcgggtgat cagcctgcac aacgatgatg tgtgctacca
2901841 ggacggtggc aactcctacg tacgcggcta ttcgggcggc gaacaacggc gctggctgca
2901901 agccgaactc gccaacgctc ggcgcgactc ggaaatcgac tgggtggtcg tctgcatgca
2901961 tcagaccgcg atctccaccg ccgacgacaa caacggtgcc gacctcggaa tccggcagga
2902021 atggctaccg ctgttcgacc agtaccaggt cgacctggtg gtgtgcggcc acgaacacca
2902081 ctacgagcgg tcacatccgc tgcgcggggc cctgggcacc gatacccgaa caccgatacc
2902141 cgtcgacacc cgcagcgacc tcatcgactc aacccgggga accgtgcacc tggtaatcgg
2902201 tgggggcggc acgtcgaagc cgaccaacgc gctgctcttc ccgcagcctc ggtgccaggt
2902261 gataaccggc gtcggggatt ttgatcccgc gatccggcgt aagccgtcca tattcgtgct
2902321 cgaggatgcg ccgtggtcgg cgttccgcga ccgcgataat ccttacggct tcgtggcctt
2902381 cgacgtcgac ccgggtcaac ccggcggcac tacctcgatc aaggcgacgt attacgcggt
2902441 gactgggccg ttcgggggac tcaccgtcat cgaccaattc accttgacca agccgcgcgg
2902501 cggatagctc agaacagggt cgcctgaacg ggtaccagtg ccgcttcggt ctccggcggc
2902561 gccgggcgat gatcacccgc caaccgatac tttgcgatca gcggtgccac ccgttcccgc
2902621 agcatctcgc ggtagctcgg cggtagatat ggcccgcgcc ggtacagttc gcggtaccgg
2902681 ctgaccagtt cgggatgcgc gcgggccagc cagcacatga accagccgcg cgtcgaaccc
2902741 cgcagatgca ggccaaagac cgttacaccg gtggcgcctg cggccgcgat ctggcccaac
2902801 agttggtcaa ggtgctcgcc ggagtcggtg agttgtggca gcaccggcgc gaccatcacg
2902861 tgacagtcca agccggcggc gcgaattgcg gtaatgagcg ccagccgcgc ctgcggtgtt
2902921 ggcgtacccg actcgacatc ccggtgcagc tccgggtcgc caacggccag cgacaccgcc
2902981 accgacaccg gcacttgttg ggcggcctcg gcgatcaacg gcaagtcccg tcgcagcagg
2903041 gtgcccttgg tcaggatcga cagcggcgta ccggatgccg ccagcgcgcc gatgatgccc
2903101 ggcatcaggg cgtagcggcc ctccgcgcgc tggtaggggt cggtgttggt gcccaacgcg
2903161 acggtctcgc gccgccagga cggccggcgc aactcgtgac gcagcacagc ggcgacgttg
2903221 gtcttgacca ccacctgggt gtcgaagtcg gtgcccggat tgaagtccag gtactcgtgg
2903281 gtggggcggg cgaaacaata gcgacaagca tgcgagcagc cgcggtagcc gttgacggtg
2903341 tagcgaaacg gcaacgcggc cgcgttgggc accttgttca gcgctgattt gcacaacacc
2903401 tcgtggaagg tgatgccgtc gaattgtggc gcgcgaacgc tgcggaccag gccgatccgc
2903461 tgcaaccccg gcagcgcccc gtcgtcaacg ggcatcccgt tcaccgcgac ggcttgccgg
2903521 gcccaacgca taccattatt cgaacaaccg ttctatactt tgtcaacgct ggccgctacc
2903581 gagcgccgca caggatgtga tatgccatct ctgcccgcac agacaggagc caggccttat
2903641 gacagcattc ggcgtcgagc cctacgggca gccgaagtac ctagaaatcg ccgggaagcg
2903701 catggcgtat atcgacgaag gcaagggtga cgccatcgtc tttcagcacg gcaaccccac
2903761 gtcgtcttac ttgtggcgca acatcatgcc gcacttggaa gggctgggcc ggctggtggc
2903821 ctgcgatctg atcgggatgg gcgcgtcgga caagctcagc ccatcgggac ccgaccgcta
2903881 tagctatggc gagcaacgag actttttgtt cgcgctctgg gatgcgctcg acctcggcga
2903941 ccacgtggta ctggtgctgc acgactgggg ctcggcgctc ggcttcgact gggctaacca
2904001 gcatcgcgac cgagtgcagg ggatcgcgtt catggaagcg atcgtcaccc cgatgacgtg
2904061 ggcggactgg ccgccggccg tgcggggtgt gttccagggt ttccgatcgc ctcaaggcga
2904121 gccaatggcg ttggagcaca acatctttgt cgaacgggtg ctgcccgggg cgatcctgcg
2904181 acagctcagc gacgaggaaa tgaaccacta tcggcggcca ttcgtgaacg gcggcgagga
2904241 ccgtcgcccc acgttgtcgt ggccacgaaa ccttccaatc gacggtgagc ccgccgaggt
2904301 cgtcgcgttg gtcaacgagt accggagctg gctcgaggaa accgacatgc cgaaactgtt
2904361 catcaacgcc gagcccggcg cgatcatcac cggccgcatc cgtgactatg tcaggagctg
2904421 gcccaaccag accgaaatca cagtgcccgg cgtgcatttc gttcaggagg acagcccaga
2904481 ggaaatcggt gcggccatag cacagttcgt ccggcggctc cggtcggcgg ccggcgtctg
2904541 accgcaaccg ggcctcatgc taggccaccg gcgaccgacg gacttcccgc gcgagccgct
2904601 ccaaaagcct cagccgctcg gggtggtcgg ctcgtcaaac gacagcccta tcagccgaga
2904661 caccacgttg tgcagcgcgt caaacacctc caggatctct tctcggctac tcgaaaccca
2904721 tgtttgaaac gtatgacgcc caccgacaag aatggccgcc ttgaggccct gcggccacgg
2904781 tggcgcaagt gatttcggtg actccggctg gaagcggcga ctacccagcc agccgcgaaa
2904841 ttacttcggc cacaaccgaa tccatcgaga ccgaaacttg ctcacccgtc gtcaagtcct
2904901 tcactgcgac cgtcccggcc tcgatgtcgc ggtcgcccgc taccaacgca acacgggcgc
2904961 cggaacgagc ggccgcgcgc atcgcgcctt tgagcccgcg atcaccatag gcaaggtcaa
2905021 cccgcacccc ggccgcgcgc agtcgtccag ccagcaccgc cagcctgagc ttggccgcct
2905081 cgccaagcgg cacgccgaac acgtcgcacc gggcgctgtc ccccgccgtc ttgccctcgg
2905141 cccgcagcgc cagcacggtc cggtccacgc ccagcccgaa cccgatgccc gacaagtcct
2905201 gcccgccaag ctggtgcatc aggccgtcgt agcgcccccc gccgccgatc cccgattgcg
2905261 caccaagccc gtcatggacg aactcgaagg cggtcttggt gtagtagtcc aggccgcgca
2905321 ccatgcgcgg gttgatgaca tagggcactc caagcgcgtc cagatgggcg agcacggtgt
2905381 cgaaatgctg cttggcgaca tcagacagat gatccagcaa caccggcgcc gacgccgtca
2905441 tcgcacgcaa ttcgggtcgc ttgtcgtcga gcacccgcag cggattgatc cctgcgcgcc
2905501 tgcgggtgtc ctcgtcgaga tcgagtccaa acaagaactc ctgcaacagt tcccggtact
2905561 gcggacggca actctcgtct cccagggagg tgatttccag ccggaacccg tcgagaccca
2905621 acgagcggaa cccggcgtcg gcaatggcga tcacctcggc gtccaacgcc gggtcgtcga
2905681 cgccgatcgc ctccaccccg acttgctgta actggcgata ccggccggcc tgcggacgct
2905741 cgtagcggaa aaacgggccc gcataacaca acttcaccgg cagcgcgccg cgatccagcc
2905801 cgtgttcgat caccgcacgc accaccccgg cggtgccctc gggccgcagc gtcaccgagc
2905861 ggtcgccacg gtcggcgaac gtatacatct ccttggacac cacgtcggtg gattcaccca
2905921 cgccccgggc gaacagggcg gtgtcctcga agatgggcag ctcgatgtgg ctatagccgg
2905981 cttgacgggc cgccgcgagc agcccgtcgc gcaccgcgac gaactgcgcc gagtcgggcg
2906041 ggacgtagtc cggtaccccc ttgggggccg aaaatgacga gaattccgtc accggctcaa
2906101 gccctcaagg aacggattga agcgccgctc ggccccaatg gtggtggagt tgccgtgccc
2906161 gggcagcacc accgtgctgt cgtcgagcac caggagtttg tcgacgatgg agcgcaacag
2906221 gtcgcggccg ctgccgccgg ccaagtcggt gcggcctatc gcacgctcga acagggtgtc
2906281 accggtgaac acgatgtcct tgtcgttgtt ggtcgcctgc aggacccgga agaccaccga
2906341 cccgcgggtg tgacccggtg tgtgatcgat gttgaccgag atgccgccga ggtcgatctt
2906401 gtcgccgtct cggtccagct ccacaacctg tttaggctca cgaaagaacg cacccgcaac
2906461 cagctgcgct atccgcgggc ccaggccgta gatggggtcg gtcagcatga accggtcggc
2906521 gggatgcaca taggtggggc agccgaaggt gtctgagacc ttctgcgcgg accagatgtg
2906581 atcgatgtgt ccgtgggtga gcagcaccgc ggcaggggtc agccggttct tgtcgaggat
2906641 gcgacgcagc gtgcccatcg caccctggcc cggatcgacg atgacggcgt cggttccggg
2906701 ccgctcggcc agcacataac agttacacgc cagcaacccc gcaggaaatc cggtgatcaa
2906761 cacggttccc agtttcccat ccccggcgtc cggggacgag gcgggccgcg aacatgggcc
2906821 acttgacacc ggtcgcggcg ccccgattag cctgtgcttt cgtgccgacc aatgctcagc
2906881 gacgtgccac agccaaacgc aaactcgaac gacaactaga gcgccgcgcc aagcaagcca
2906941 aacgccgtcg catcttgact atcgtcggtg gctcactcgc agcggtggcc gtgatcgtcg
2907001 cggtagtcgt cacggtggtg gtcaacaagg acgaccacca gagcaccacg tcagcaaccc
2907061 ccaccgactc ggcctcgacc agccccccgc aggccgcgac cgctcccccg ctgccgccgt
2907121 tcaagccgtc ggccaacctc ggcgccaact gccagtaccc gccgtcgccg gacaaggccg
2907181 tcaaaccggt caagttgccc cggaccggca aggtacccac cgacccggcc caggtcagcg
2907241 tgagcatggt gaccaaccag ggcaacatcg gtctaatgct ggccaacaac gaatcgccgt
2907301 gtacggtcaa tagtttcgtc agcctcgcgc agcagggttt cttcaagggc accacttgtc
2907361 accggctgac cacctcacca atgttggcgg ttctgcaatg cggcgaccct aagggcgacg
2907421 gcacgggcgg tccgggctac cagttcgcca acgaataccc caccgaccaa tactcggcga
2907481 acgaccccaa gttgaacgag cccgtcatct atccgcgcgg gacactggcc atggccaacg
2907541 ccggccctaa taccaacagc agccagttct tcatggtcta ccgggactca aagctgccac
2907601 cccaatacac cgtgttcggc acgatccagg ccgacggact gaccaccctg gacaagatcg
2907661 ccaaggccgg cgtcgccggt ggcggcgaag acggcaagcc cgccaccgaa gtcaccatca
2907721 cgtcggtgct gctggattag cccgacgctc gccgagcaga cacagaatcg cacgaaatca
2907781 gcccgcccaa tgcgattctg cgtctgctcg gcggagaaaa gcgcgctacg cggccgaggt
2907841 cacccggtag acgtcgtaga caccttcgac gttgcggacg gcgttgagca ggtgcccgag
2907901 gtgcttgggg tcacccatct cgaaggtgaa tcgactgatc gccacccggt cccccgaagt
2907961 ggtgaccgac gcggacagga tattgacctt ctcgtcggcc agtgcgcgcg tcacatccga
2908021 cagcagccgg tgccggtcga gtgcctcgac ctggattgcc accagaaaca ccgacgacgg
2908081 cgacggcgcc catagcacct cgatgatgcg ctcggcctgc tgctgcagcg atgcggcgtt
2908141 ggtgcagtcg gtgcggtgca cactgacccc gccgccacgg gtgacgaacc ccataatcac
2908201 atcgcccgga accggcgtgc agcacttggc cagcttggtc agcacgcccg gggcgccggg
2908261 gacggagacc ccgacatcgt cggtgctgcg tgggcgccgc ggcatggtcg ccggcgtgga
2908321 ccgctcggcg agttcctctt ccgcctggtc gataccgccg agctcggcca acaaccgctg
2908381 cacgacgtgt ttcgccgaca cgtgcccctc accgatggcg gtatagagtg ctgacacgtc
2908441 cgcgtagtgc agctcgcggg ccaccgccgc catggactca ccattgacca agcgctgcaa
2908501 cggaagtcca ccgcggcgca cctcgcgggc catcgcatcc ttaccggtct ccaacgcctc
2908561 ctcacgccgc tccttggcga accactggcg gatcttcgtc tttgcgcgcg gcgacaccac
2908621 gaactgctgc cagtcccgcg acggcccggc gttcggcgcc ttggacgtga aaacctcgac
2908681 aacttctccg ttttccagct tgcgttccag cgctaccaac cggccgttca ctcgggcgcc
2908741 gatgcagcgg tggcccacct ctgtgtgcac cgcgtaagcg aagtccaccg gcgtcgaacc
2908801 ggttggcagc gtgatcacgt cgcccttggg ggtaaacacg aaaatctctt gcaccgcaag
2908861 gtcgtagcgc aatgattcca agaactcacc ggggtcggcc gcctcacgtt gccagtcgag
2908921 cagctgacgc atccaggcca tgtcgtcgat ctccgcggcg gcatgcggat gaagaacacc
2908981 gttgcggccc ttggcttctt tgtagcgcca atgcgcggcg atgccgtatt cggcggtgcg
2909041 gtgcatgtcg cgggtacgga tctgcacttc cagcggcttg ccctcaggcc cgaccacagt
2909101 ggtgtgcagt gactggtaca caccgtatct gggctgggcg atgtagtcct tgaaccgacc
2909161 cgccatcggc tgccatagcg aatgcactac gccgacagcc gcgtagcagt cccggatttc
2909221 gtcgcacagg atgcgcacac cgaccaggtc gtggatgtcg tcgaagtcgc ggcccttaac
2909281 gatcatcttc tggtagatcg accaatagtg cttggggcgg ccctccaccg tcgccttgat
2909341 cttcgacgcg gtcagcgtgt tgacgatttc ggcacgcacc ttggccaggt aggtgtcccg
2909401 ggacggcgcg cgaccggcga ccagccggac gatctcctcg tacttcttgg gatgcaggat
2909461 cgcgaaggac aggtcctcca actcccactt gacgctggcc atgcccagcc gatgcgccag
2909521 gggtgcaatg acttccaacg tctcacgggc cttgcgggcc tgcttctccg gcggcaagaa
2909581 gcgcatggtg cgcatgttgt gtaaccggtc agccaccttt atcaccagca cccgcggatc
2909641 gcgggccatc gcggtgatca tcttgcgaat agtctcgcct tcggcggcgc tgcccaacac
2909701 cacccgatcc agcttggtca ccccgtcgac gagatggccc acctcttcgc cgaattcctc
2909761 ggtcaacgcc tccagggtgt aaccggtgtc ctcgacggtg tcgtgcagca gcgcggccac
2909821 caaagtggtg gtgtccatgc ccaactcggc cagaatgttg gcaacggcca acgggtgggt
2909881 gatgtaggga tcaccggact gccgcaactg gctggcatgc ctttggtcag cgacctcgta
2909941 ggctcgctgc aagatcgaca ggtcggcctt gggatagatc tcccggtgca ccgccaccaa
2910001 cggctcgagc accggattgg tggtgctgcg ctgggcggtc atccgccggg ccaatcgggc
2910061 ccgcacccga cgcgacgcgc tgatgctggt cttaagagtc tcgaccggcg actcgggcgt
2910121 ctcgagagcg ggctcgagag ccgcagaagc ctccgtgggc ggtgcaaccg cttgcgccgt
2910181 gagctggtcc tcggccacgt tcgtcacctc cgacctagag gatatccctc acaggcggct
2910241 caggctgtgc accggcagcg gtgcgagcgc cgcgcgaccg ctcaaccccg caagttccac
2910301 cactacggcc gccccggcca cgttggcgcc accgcgctca agcaggcgtc gcgtcgcgcc
2910361 gatggtgccg ccggttgcta acacgtcgtc aatgatcacg acacggcggc ccgcaacctc
2910421 gatgccctca gcgagaatct ccagagtggc ggcgccgtac gccctgtagt actcctcgct
2910481 gagcaccggc cggggcagct tgccgccctt gcgaacggcc agcacaccca cttcgagccg
2910541 ggtggcgacc gcggctgcca ccagaaaccc gcgggcgtcg acgccggcca ccaggtcagc
2910601 tccggacgcc cgatcggcca gcgcttcggt taccgcggcc aatcctcttc ggtcggcgaa
2910661 tagcggggtg aggtccttga actcgacgcc gggaaccgga aagtcggcca catcccgggt
2910721 cagcgacgca accacgtcgg ccacagatat ggctgagctc cggcgggact caccgagcgc
2910781 caatacccgc ccgtcgtcga cccaacgctg ccggcggcgc ttcccccgtg cctttaagga
2910841 gagccccgtc gcgatcacgt tcaacacgta gtcaccagcc catgtaccgc catggcacac
2910901 atcctctccc agacagcccg gagcacctgc gacactacgc tccgataggt ccgcttctcg
2910961 tcgtggaatt ctgtcaatta cctgcagatg gcactggcca tcgtcaccgc gccagcgccc
2911021 agcgatccat gttccaccct gccccccatc gcgtcggatt cctgctcacc gcatacattt
2911081 tcgtcgacat caacaacgtg cgctgctgcc ggtacaacgg caaggttggc atctcatccc
2911141 agagcaccgg cgcggcctcg gcaagcaacc tggcccgctc ggcggggtcg gccgacaccg
2911201 cgagcgcgct gatgatgccg tcgatctgag cgtttgcgta ccccgataga ttgtttccgt
2911261 tgccgctgtg caagtcatag gcatccatcg cacacgatcc gctcgatccg ctgccggtgg
2911321 ccccaccggt gctcgccaac aatacgtcaa tctttccgtc ccgcagcgct tgcggtccgg
2911381 gtgtgtccac cgtcacatcc gaaacggtga tcccggccgg ggcgcaggcg tcggcaatgg
2911441 ttccgatggt ggccgccaac cgagcgttgg gcctgccgta gccgatccgc acggtcagcg
2911501 gcgtaccacc cagcgcgtcg cgagcggcgg cggggtccac ccggccgaac tgacgtgctt
2911561 cggcggcgcc gtcggcatcg gtgagggcat cgtcggtcgc cggggacagc cgcgagttgg
2911621 caatcggaac cccggcatcc cgagcgatcg cgtcccgggg tacacacaac gcgagcgcgc
2911681 ggcgggtgcg gctttgcgcg agtgaacctt gtggtgcgaa gatcagctgc tcgatcccgg
2911741 ccgacgggta gtcggtgcgc tggtagctgt cgggggttac cagggatccc gatgaaccgg
2911801 ccgcgacgtc gaccacgtcg acgctgcggt tgttgacccg gtcttggata tcggctccct
2911861 gcggccagac ggtgatccgc ttcgtgatcg ccttggtgcc ccaccaacga tcattggcga
2911921 cgagcaccac ggcgccatcg tccaggacgg attcgatctt gtacggtccc gacgagggga
2911981 agcggctgcg gacttcgtcg tggctgcggc ccggcttgag gtcccacgtg gaattccaca
2912041 gtcgcgcaat ctgttccacc gctgacacgt tgttgcttag caacgccgcg gtaacatcga
2912101 tgtgcagctg gtcggcgatc acgtgcgacg gcatcagcga cgtcgcggtg aacagctggg
2912161 agtggtcaac gacactgcga tccgggatga acgacacccg ggcctttttc tgccccgccg
2912221 tgcactcgat gttggcgatg tcgacatagc cggcctgcgt agcagcgtcg aagccgggaa
2912281 agcggccgga ttgtgccgcc caggccaata ccaggtcgtc acaggtcacc ggcctgccgt
2912341 cggaatagac ggcgtcgtcg gagatctggt agtcgaggat caacggcgac ccctccacca
2912401 ccgagaccgt tccgaagtcg cggtcagcca ccacttggcc gtcggggccg tgatagccaa
2912461 acccggtgag agtccgggcg aatgcctgcg ccccggccga cgcggcaccg atgacggtat
2912521 tggtgttgta ggtgaccagc gcgccgtcga ccacgtagtc gatctgagcc gcggcgctgc
2912581 ccgaacacgc ggtcagcgtg gttgcggcga ccaacgtcgc ggtaccaacg actcgcaggc
2912641 cggcgatgcg cgtatgacgc cggcggcggg gggccaccgc gcctaccgcc gaccggcgtt
2912701 ccgcttgccg gtcggacgcc tggtaccgac gggacgcact gggcgcgccc ccggcgccgg
2912761 cttgctggag ccctgggccg cccgcggggc ggattggctg ctggcctgcg tgatccccac
2912821 cagcgactgt tcatcagcgg ctgccggctg ctcgccgcca tccgtgctgg cgtcctctga
2912881 tcccgccggc gagccggagt tacgccgttt gagcacccga cgggtgtggt tgcgcaccaa
2912941 ctccgtgcgc tcacggaggg taaccaacag cggcgtggcg aagaagattg acgagtaggt
2913001 gccgatgatg atgccgatca gctgcaccag cgccaggtct ttgagagtgc cgacgcccag
2913061 cagccagacc gccaccacca tcagcgccaa caccggcaac acgccgatca ggctggtgtt
2913121 gatcgaccgc atgaacgtct ggttgatcgc caggttggcc tgctcggcga aggtgcgccg
2913181 ggtggtgtgc tggaagccat gggtgttctc ctcgaccttg tcgaacacga tgacggtgtc
2913241 atagagcgag aacccgagaa tggtcagcag gccgatgacc gtggccgggg tgacttcgaa
2913301 acccaccagg gaatacacgc cggcggtgac ggtcaggtcg aagagcatgg ccgttatcgc
2913361 cgagatggtc atgtagcgct cgtagcgcac ggtaatgtag agggcgacca gcaccagaaa
2913421 caccaccagc gcgatcaccg ccttcttggt gatctgaccg ccccaggtct ccgacaccgc
2913481 cgagtcgctg atggcctgct tgctgggctg accgtcggtt cccttgggcc cgaaggcctc
2913541 gaatagggcg tcccgcagct tggccgtctg gtcgctggtc agcgtctccg aacgaatctg
2913601 caccgtcgcc gaagcaccgg ccccgacgat caccaccgac tggggctcac tgccgagggc
2913661 ccggtagtag acgtcttcga cctgcgcgac ttgggtgctg ccacgcggga acgacaccgt
2913721 ggtaccgcct ttgaaatcga tgccgaaggt gaacccacga aagacgatgc tggcgatggc
2913781 caccgcgacg atcgcaccgc tcacgccaaa ccacaaccgg cggcgtccca ctacctcaaa
2913841 cgccccggtg ccggtgtaca ggcgcgaaag gaagctatgg tgccccagct tcgaggcggt
2913901 gtctgtggtg ctgtcgccgt cggtccgcgc cacagcactc tcggtggcct cggtgagttc
2913961 gaccgccgac gtggcttcgt cgtcgcggcc ggtctttgct ttcgacgcca tcggctatcc
2914021 ccgtcccgtc cgagccatgg cccggcgttc gcgtgcgacc tgctgcaccg ctcccaggcc
2914081 gttgtatgcc ggcttggcca gcagcgacga tttggacgcc agatacacca acggccacgt
2914141 caccaagaac accacgacga ggtccaggat cgtggtgagg cccagggtga acgcgaaccc
2914201 cttcacctga ccgatcgcca gaaagtacag cacggcagcg gccaggaaag tgacggcgtt
2914261 gcccgacacg atcgtcttgc gggcacgcgc ccaaccgcgc ggcactgccg accggaacga
2914321 acggccttcg cggatctcgt ctttgatgcg ttcgaagaac accacgaacg agtcggcggt
2914381 ggtcccgata ccgatgatca ggcccgcaat accagccaga tctagggtgt agttgatata
2914441 tcggcccaag agcaccagga tcgcaaaaac cattgagcca gaagccacta gcgacaaggc
2914501 cgtgagcagt cccagcactc ggtagtagag cagcgaatac accagcacca acagcaggcc
2914561 gatcgcaccc gcgatcatgc ccgcgcgcag cgatgacaac cccaaggtcg ccgaaaccgt
2914621 ttgggcttcc gacggttcga aggacagcgg cagcgacccg tacttgagga cgttggcgag
2914681 ctggcgtgcg gtcgccgcgg tgaatggcgg atccccaccg ctgatctggg ttcggccgcc
2914741 ggggatcgct tcctggatct gcggtgcact gacaacctgc gagtccaggg tgaacgccgt
2914801 ctgggtgccg atatgggcgg cggtgtagtc ggcccagatg ttggccgccg gacccttgaa
2914861 ctgcaggtcg acgacgtagc cgatgccgcg ctggtccata cccgaggtgg cgttttggat
2914921 ctggtcgccg ctgatgatcg acggcgccag caggtacgcg gtcttgtggt cggtcgagca
2914981 ggtcaccaac ggcagtttcg ggtcgtcgtt gccggccaaa atgtcgtcgc tctcgcagcg
2915041 ggtcgcctgg aattgcagtg caaccatctg catgtattgg ttggtgctct gccgcagctt
2915101 cttctcctgg gcgatgcgct cggcgagatc cttgcgcgga tccgtggccg gcgcctcagc
2915161 gggcggcgcc ggcggcgggc tggccggtga ggtcgggttg ggcgatggcg ccgggtcctg
2915221 cggatagggc cgcggttggg ccccaggttg cggtgaagcc ggcgcccccg attgggctgg
2915281 cggcggtgcg gcgggttgac cgggcggctg cggttcggcg ctgggtgccg gctgcggttc
2915341 ttcggctgcg ggctgcgccg gcatcgagtt gagcaccggc cggatgtaca gccgagcggt
2915401 ctgtccgagg ttgcgtgcct cgctgccgtc gttgccgggc accgtgatga ccaggttgtc
2915461 accgtcgacg accacctccg acccggacac tcccagcccg ttgacccgcg cgctgatgat
2915521 ttgctgcgcc tgtgccagcg cttcccggct cggggccgag ccgtccggtg tgcgcgcggt
2915581 cagcgtgacc ctggtgccgc cctgcaggtc aatgccgagt ttgggggcgg tgtgcttgtc
2915641 cccggtgaaa aacaccagca aatagatgcc gatcagcatc accaggaaca ccgacaggta
2915701 acgggcaggg tgcaccggcg ccgaagacga tgccacgttc cttgtatctc ctcgagaatc
2915761 agttttctac ccccgacaga gcctacgtgt cgcgccgggg cgcgtcgcgc aagcggctcg
2915821 tcggttccgg tcggccggtt gccggtcagg aatcgttggt cacccggcgc tcgccggcca
2915881 cgtcgtcaac atccttgtca aggtcctcgt tgagctcctc gtcgatgtcg tcgtccggca
2915941 gaattcggtc acgaatcgcc aacttcatcc acgtggtgac caccccgggc gcgatctcga
2916001 ggtcgatggt gtcgtcggca atggcgacga tggtggcttc cagcccagaa gtcgtgtgta
2916061 cccgctcccc gggctgcaac gagtcgtgca gatcgatggt ggcttgcatg gcccgtcgct
2916121 ggcggcgcga cgcgaagtac atgaacccac ccatgatgag caggaacggc aagaacaaaa
2916181 cgaaactctc catcaacccg tctttcgtat tggtattgcg atcacggtgc caggcctacc
2916241 cgcgggccgc gcacctggta acagtccagt gtgcccgtcc agtctggcag gccggaaaca
2916301 tcggtcagca gataggcttt accagcgatg tgaaccggcg agccgggtga ggaggatctg
2916361 tggccagcct gcagcagagt cggcgcctgg tcaccgaaat ccccggtccc gcatcgcagg
2916421 cactgactca ccgccgggcg gcggcggtgt ccagcggtgt tggggtcacc ctgccggtgt
2916481 tcgtagcccg cgccggcggc ggcatcgtgg aagacgtgga cggtaaccgg ctcatcgacc
2916541 tgggttcggg catcgcagtg acgacgatcg gcaactcgtc gccacgcgtg gtggatgcgg
2916601 tgcgcacgca ggtggccgaa tttacccaca cctgcttcat ggtgacgcca tacgaggggt
2916661 acgtggccgt cgccgagcaa ctcaaccgga ttaccccagg ttcgggcccc aagcgctcgg
2916721 tgttgttcaa ttccggcgcc gaggcagtcg agaacgccgt caagatcgca cgctcctaca
2916781 ccggcaagcc cgcggtggtg gcgttcgacc acgcctacca cggtcgcacc aacctaacga
2916841 tggcgctgac cgccaagtcg atgccctaca agagcggctt cggtccgttc gcgccggaga
2916901 tctaccgagc gccattgtct tacccctatc gggacggcct cctcgataag caactggcta
2916961 ccaatggtga gctagccgcg gcccgagcca tcggcgtcat cgacaagcag gtaggcgcga
2917021 acaacctggc cgccctcgtc atcgaaccga tccagggcga aggcggtttc atcgttccgg
2917081 ccgaagggtt cctacctgcc ctcctcgatt ggtgccgcaa gaaccatgtg gtgttcatcg
2917141 ccgacgaggt gcaaaccggc tttgcccgta ccggggcgat gttcgcctgc gagcacgagg
2917201 gccccgacgg tctagagccc gacctgatct gcacggccaa aggcatcgcc gatggattgc
2917261 cgctgtcggc ggtcaccggc cgcgccgaga tcatgaacgc cccgcacgtg ggcggcctgg
2917321 gcggcacgtt cggcggcaac ccggtggcct gtgcggccgc gctggccacc atcgcaacca
2917381 tcgaaagcga cgggctgatc gagcgggccc gccagatcga acgcctggtg accgaccggt
2917441 tgacgacgct gcaggccgtc gacgaccgga tcggcgacgt gcgtggtcgc ggcgccatga
2917501 tcgccgtaga gctggtcaaa tccggaacca ccgagcccga cgccgggctg accgagcggc
2917561 tggcgaccgc ggcccacgcc gccggcgtca tcattttgac ctgcggcatg ttcggcaaca
2917621 tcatccggct actgccgccg ctgaccatcg gcgacgagct gctgagtgag gggctggaca
2917681 tcgtgtgcgc gatcttggcc gacctctgac ggcctgccgg ccccgactgc gtcatcccgt
2917741 gccgcatctc acagccgatc agcagcaggc ttgcattgtg taatatattt actttagcta
2917801 acgttctatt ggtcgggcgc agcgccgcgc cgtcgatttc ccaccctttc cggcacgccg
2917861 aggtgaccgc atgtcgatca acgatcagcg actgacacgc cgcgtcgagg acctatacgc
2917921 cagcgacgcc cagttcgccg ccgccagtcc caacgaggcg atcacccagg cgatcgacca
2917981 gcccggggtc gcgcttccac agctcatccg tatggtcatg gagggctacg ccgatcggcc
2918041 ggcactcggc cagcgtgcgc tccgcttcgt caccgacccc gacagcggcc gcaccatggt
2918101 cgagctactg ccgcggttcg agaccatcac ctaccgcgaa ctgtgggccc gcgccggcac
2918161 attggccacc gcgttgagcg ctgagcccgc gatccggccg ggcgaccggg tttgcgtgct
2918221 gggcttcaac agcgtcgact acacaaccat cgacatcgcg ctgatccggt tgggcgccgt
2918281 gtcggttcca ctgcagacca gtgcgccggt caccgggttg cgcccgatcg tcaccgagac
2918341 cgagccgacg atgatcgcca ccagcatcga caatcttggc gacgccgtcg aagtgctggc
2918401 cggtcacgcc ccggcccggc tggtcgtatt cgattaccac ggcaaggttg acacccaccg
2918461 cgaggccgtc gaagccgccc gagctcggtt ggccggctcg gtgaccatcg acacacttgc
2918521 cgaactgatc gaacgcggca gggcgctgcc ggccacaccc attgccgaca gcgccgacga
2918581 cgcgctggcg ctgctgattt acacctcggg tagtaccggc gcacccaaag gcgccatgta
2918641 tcgcgagagc caggtgatga gcttctggcg caagtcgagt ggctggttcg agccgagcgg
2918701 ttacccctcg atcacgctga acttcatgcc gatgagccac gtcgggggcc gtcaggtgct
2918761 ctacgggacg ctttccaacg gcggtaccgc ctacttcgtc gccaagagcg acctgtcgac
2918821 gctgttcgag gacctcgccc tggtgcggcc cacagaattg tgcttcgtgc cgcgcatctg
2918881 ggacatggtg ttcgcagagt tccacagcga ggtcgaccgc cgcttggtgg acggcgccga
2918941 tcgagcggcg ctggaagcgc aggtgaaggc cgagctgcgg gagaacgtgc tcggcggacg
2919001 gtttgtcatg gcgctgaccg gttccgcgcc gatctccgct gagatgacgg cgtgggtcga
2919061 gtccctgctg gccgacgtgc atttggtgga gggttacggc tccaccgagg ccgggatggt
2919121 cctgaacgac ggcatggtgc ggcgccccgc ggtgatcgac tacaagctgg tcgacgtgcc
2919181 cgagctgggc tacttcggca ccgatcagcc ctacccccgg ggcgagctgc tggtcaagac
2919241 gcaaaccatg ttccccggct actaccagcg cccggatgtc accgccgagg tgttcgaccc
2919301 cgacggcttc taccggaccg gggacatcat ggccaaagta ggccccgacc agttcgtcta
2919361 cctcgaccgc cgcaacaacg tgctaaagct ctcccagggc gagttcatcg ccgtgtcgaa
2919421 gctcgaggcg gtgttcggcg acagcccgct ggtccgacag atcttcatct acggcaacag
2919481 tgcccgggcc tacccgctgg cggtggttgt cccgtccggg gacgcgcttt ctcgccatgg
2919541 catcgagaat ctcaagcccg tgatcagcga gtccctgcag gaggtagcga gggcggccgg
2919601 cctgcaatcc tacgagattc cacgcgactt catcatcgaa accacgccgt tcaccctgga
2919661 gaacggcctg ctcaccggca tccgcaagct ggcacgcccg cagttgaaga agttctatgg
2919721 cgaacgtctc gagcggctct ataccgagct ggccgatagc caatccaacg agctgcgcga
2919781 gctgcggcaa agcggtcccg atgcgccggt gcttccgacg ctgtgccgtg ccgcggctgc
2919841 gttgctgggc tctaccgctg cggatgtgcg gccggacgcg cacttcgccg acctgggtgg
2919901 tgactcgctc tcggcgctgt cgttggccaa cctgctgcac gagatcttcg gcgtcgacgt
2919961 gccggtgggt gtcattgtca gcccggcaag cgacctgcgg gccctggccg accacatcga
2920021 agcagcgcgc accggcgtca ggcgacccag cttcgcctcg atacacggtc gctccgcgac
2920081 ggaagtgcac gccagcgacc tcacgctgga caagttcatc gacgctgcca ccctggccgc
2920141 agccccgaac ctgccggcac cgagcgccca agtgcgcacc gtactgctga ccggcgccac
2920201 cggctttttg ggtcgctacc tggcgctgga atggctcgac cgcatggacc tggtcaacgg
2920261 caagctgatc tgcctggtcc gcgccagatc cgacgaggaa gcacaagccc ggctggacgc
2920321 gacgttcgat agcggcgacc cgtatttggt gcggcactac cgcgaattgg gcgccggccg
2920381 cctcgaggtg ctcgccggcg acaagggcga ggccgacctg ggcctggacc gggtcacctg
2920441 gcagcggcta gccgacacgg tggacctgat cgtggacccc gcggccctgg tcaaccacgt
2920501 gctgccgtat agccagctgt tcggcccaaa cgcggcgggc accgccgagt tgcttcggct
2920561 ggcgctgacc ggcaagcgca agccatacat ctacacctcg acgatcgccg tgggcgagca
2920621 gatcccgccg gaggcgttca ccgaggacgc cgacatccgg gccatcagcc cgacccgcag
2920681 gatcgacgac agctacgcca acggctacgc gaacagcaag tgggccggcg aggtgctgct
2920741 gcgcgaagct cacgagcagt gcggcctgcc ggtgacggtc ttccgctgcg acatgatcct
2920801 ggccgacacc agctataccg gtcagctcaa cctgccggac atgttcaccc ggctgatgct
2920861 gagcctggcc gctaccggca tcgcacccgg ttcgttctat gagctggatg cgcacggcaa
2920921 tcggcaacgc gcccactatg acggcttgcc ggtcgaattc gtcgcagaag ccatttgcac
2920981 ccttgggaca catagcccgg accgttttgt cacctaccac gtgatgaacc cctacgacga
2921041 cggcatcggg ctggacgagt tcgtcgactg gctcaactcc ccaactagcg ggtccggttg
2921101 cacgatccag cggatcgccg actacggcga gtggctgcag cggttcgaga cttcgctgcg
2921161 tgccttgccg gatcgccagc gccacgcctc gctgctgccc ttgctgcaca actaccgaga
2921221 gcctgcaaag ccgatatgcg ggtcaatcgc gcccaccgac cagttccgcg ctgccgtcca
2921281 agaagcgaaa atcggtccgg acaaagacat tccgcacctc acggcggcga tcatcgcgaa
2921341 gtacatcagc aacctgcgac tgctcgggct gctgtgatcg ggcctggccg ccgcggcgcc
2921401 gggtaaccaa gcagcccgtt acgcccagtt cgcctatgag aaggcagtaa gaagcgcgaa
2921461 aaatggcaga ccccgacgga ggccctctga aagagtcttg atcatcaggg cgcgtgacat
2921521 gtgtcacatg acgggttggg agggtggctg atgtcgtttg tcacggcagc tccagagatg
2921581 ctggcgacgg cggcgcagaa tgtcgcgaat atcggcacat cgctgagtgc ggcaaacgcg
2921641 acggcagcgg cgtccacgac ctcggtgctg gcggccggag ccgacgaggt atcgcaggct
2921701 atcgcaaggc tgttcagtga ttacgccacg cactatcagt cgctgaacgc tcaagccgcg
2921761 gcatttcatc acagcttcgt gcaaacgttg aacgccgccg gtggcgccta ttcgagcgcc
2921821 gaggcggcca acgcttcggc gcaggcgttg gaacagaatc tgttggccgt gatcaatgcg
2921881 cccgcccagg cgttgttcgg gcgtcccctg atcggcaatg gcgcgaatgg aacagcggcc
2921941 agccccaacg gcggtgatgg tgggattttg tacggcaacg gcggcaacgg cttctcccaa
2922001 acgaccgccg gggtggccgg cggcgccggt ggttccgcgg gcctgatcgg caacggcggc
2922061 aatggtggcg ccggtggggc cggtgctgcc ggcggggccg gcggcgccgg cggatggctg
2922121 ctcggcaacg gtggcgccgg cggtcccggc ggcccaacgg acgttcctgc cggcacaggt
2922181 ggagccggcg gggccggcgg cgacgcccca ttgatcggct ggggcggcaa cggcgggccc
2922241 ggcggtttcg ctgcttttgg aaacggtggg gccggcggca acggcggcgc cagcggttcg
2922301 ctctttggcg tcggcggcgc cggcggcgtc ggcggatcga gcgaagacgt cggcggcacc
2922361 ggcggggccg gcggcgctgg ccgcggtcta ttccttggcc tgggcggtga tggcggcgcc
2922421 ggcggcacca gcaacaacaa cggcggtgac ggtggcgccg gcggcaccgc gggaggtcga
2922481 ttgttcagcc tgggcggtga cggtggcaac ggtggtgccg gtaccgcaat cggatccaac
2922541 gccggtgacg gtggcgccgg cggtgacagc agcgccctga tcggctacgc ccagggcggc
2922601 tccggcggcc tcggcggctt cggcgaaagt accggcggcg acggcggcct gggcggcgcc
2922661 ggcgctgtgc tcatcggcac gggcgtcggc ggtttcggcg gcctcggtgg cggctccaac
2922721 ggcaccgggg gcgcgggcgg cgcgggcggc acgggcgcca cgctgatcgg cctgggcgcc
2922781 ggcggcggcg gcggcatcgg cgggttcgcc gtcaacgtgg gcaacggcgt cggcggtctg
2922841 ggcggccagg gcggccaggg cgccgcgctg atcggcctgg gcgccggcgg tgccggcggt
2922901 gccggcggcg ccacagtcgt tggacttggt ggcaatggcg gtgacggcgg tgacggtggc
2922961 ggcctgttta gtatcggcgt cggtggggac ggcggcaacg ccggcaacgg cgccatgcct
2923021 gccaatggcg gcaacggcgg caacgccggg gtcattgcca acggctcctt tgccccgtcg
2923081 ttcgtcggct tcggcggcaa cggcggcaac ggcgtcaatg gcggcaccgg cggcagcggc
2923141 gggatccttt ttggcgccaa cggcgcgaac ggaccgtcgt agcgggtcct ccagcgcact
2923201 actcgaacaa ccccggttga ctcgctccga ccggtggcgt catgcccagg tgcgtccagg
2923261 ccagggcggt ggccacccgg ccgcgcgggg tgcgcgcgac catacccgcg cgcaccagaa
2923321 atggttcgca cacctcctcg accgtggcgg cctcctcccc gaccgccacc gccagcgtcg
2923381 acacacccac tggaccaccg ccgaagctgc gggtcagcgc cgagagcacc gctcggtcca
2923441 gccggtccag acccagctcg tcgacgtcgt agacctccag tgcggccttg gcgacgtcgc
2923501 gggtgatgac gccgtcggcg cgcacctcgg cgaagtcacg cacccggcgc aacaaccggt
2923561 tggcgatccg cggcgttccc cgagaacggc gggcgatttc ggcgccggcg tcggcgccca
2923621 gctcgatacc cagaattccg gcggagcggg ccagcacccg ctccagctcg gcgggctcgt
2923681 agaaatccat gtgcgcggtg aagccgaacc ggtcgcgcag cgggccggtc aacgcgcccg
2923741 accgggtagt cgccccgacc agggtgaacg gcgcgacctc cagcggaatc gacgtggccc
2923801 caggaccttt gccgaccacc acatcgacgc ggaagtcttc catcgccaga tacagcatct
2923861 cctcggcggg ccgggcgatg cggtggatct cgtcgataaa caacacgtcg tgctcgacca
2923921 ggttggacag catcgccgcc aggtcaccgg cgcgttccaa cgccggcccc gacgtcaccc
2923981 gcagcgagga ccccagctcg gcggcgatga tcatcgccaa cgacgtcttg cccaagcccg
2924041 gcggaccgga cagcagaatg tgatccggtg tgccgccgcg gtttttggct ccctcgatga
2924101 ccagctgcag ctgttcgcgg acccggggct ggccgatgaa ttcgcgtaac gagcgcggcc
2924161 gcaggctgac gtcgatgtcg ccctctccga cggtgagtgc gggcgaaacg tcgcggtcgg
2924221 accgctcggt catcgggcct tccccagcaa cgacaaggca gaccgcagcg cgctggatgt
2924281 cgtcgcgtca tggttggcgg ccagcaccgt atcggtggcc tcctcggcct gtttggccgc
2924341 aaagcccagg ccgaccagag cctcgaccac gggactgcgc accgcgtggc cgttggtcga
2924401 gagtgcgccg ccggtggctg ccaccccaac cttgtcgcgt agttccaaca ccatgcgttc
2924461 ggcgccccgc ttgccgatcc caggcacccg ggtcagggcg gcgacgttgc cgtcggccag
2924521 cacctgccgt agcgccggag cgtcgtgcac ggccagtgcc gccatcgcca gccggggccc
2924581 aacgccggag accgacagca gcgtcaggaa taggtcgcgg gtttccccgt cgggaaaccc
2924641 gtacagcgtc atcgagtcct cgcgcacaat catcgcggtg atcagccggg cctcggtgcc
2924701 ttgccgcaac gtcgccagcg tcgccggtgt cgcgttcact cggtagccca caccggcggc
2924761 ctcgatcacc acatggtcaa gcgccacctc gagcacctca ccgcggaccg aggcgatcat
2924821 cgggcggcct tcagcttggc taggtacgca tgacgctgct gcgctgctcg tgcttccgcc
2924881 ctcgacgtgg cctcagccat ccgggcgatc gtcggcgccc gccaacagtg acagatcgcc
2924941 agcgccaaag cgtcggccgc gtcggccggt gtcggtttag cttgcagcgc aaggattttg
2925001 gtgaccatcg cggtgacctg agccttgtct gcggaaccgt tgccagtgac cgccgccttg
2925061 acctcgctgg gggtatggaa atgcacgtcg acaccacgtt tggccgccgc cagggcgatc
2925121 acgccgccgg cctgcgcggt gcccatcacc gtggtcacgt tgagctgaga gaacacccgt
2925181 tcgatagcca ccacctccgg atgatgggtg tccagccagt gctcgacggc atcgctgatg
2925241 gccaacaggc gctgcgccaa ggccgcatcc gacggtgtgc gcaccacgtc gacatccagc
2925301 gcggtgagct gccgaccacg cccactctcg ataagcgaca gcccgcatcg ggtcaacccg
2925361 ggatcgacac ccatcacccg caccgcacgc tccctcagcc atttccgaac aatcgttcga
2925421 tacgctagcg gatcgtcccg acatcccgcg caggacacgc ctatggaacg tgcgatggta
2925481 aatttcctac catgcgaaca accatcgatg tcgcaggacg tctggtgatt cccaagcgga
2925541 ttcgcgagcg ccttggcttg cgcgggaacg accaggtgga gatcaccgag cgcgatgggc
2925601 gcatcgagat tgagccggcc ccgaccggtg tcgaactcgt tcgggaaggc tcggttctcg
2925661 tcgcacggcc agaacgtccc ctgcccccgt tgaccgacga aatcgttcgg gaaacgctcg
2925721 atcgcacacg gcggtgatcg caccagacac cagcgtgctg gttgccggat tcgcgacctg
2925781 gcacgaaggg cacgaggccg ccgtgcgcgc gctcaaccgt ggcgtccatc tgatcgcgca
2925841 cgcggctgtg gaaacctatt cggtcttgac ccggctacca ccgccgcatc gtattgcccc
2925901 tgttgccgtc cacgcctact tggcggacat cacctccagc aactacctgg cactggatgc
2925961 ctgctcatat cgcggcttga ccgaccacct cgccgagcac gatgtcaccg gtggcgcaac
2926021 ctacgatgcc ctggtcggct tcacggcgaa agctgccggc gcaaagctgc tgactcgcga
2926081 cctgcgcgcg gtcgaaacgt acgagcgatt gcgggtcgag gttgagctgg tgacctgaga
2926141 aaccgttgcc gttgagtgtg tttgagttgc acgctcaccg acacccggat ggtgcaccag
2926201 tgagctgggg tgaccgcggc cgagacctgc cgggttcccg gccggacaac tcgcccgttg
2926261 tgacccccgg tcccgcgaaa gctgttacgt taaacggcgc catcgatatg cgaccgatcg
2926321 accaaccgcg gcgcagcggt acgagagggt atgcgtggga aatctgctgg tcgtgattgc
2926381 cgtggcgctg ttcatcgccg ccatcgtcgt tctcgtcgtg gccatccggc ggcccaaaac
2926441 accagccacg ccgggcgggc gccgggatcc gctggccttc gacgcaatgc cgcaattcgg
2926501 cccccgccaa ctcggacccg gcgcaattgt cagccacggt ggcatcgact atgtggtccg
2926561 cggatcagtc acctttcgcg agggtccctt cgtgtggtgg gaacacttgc tggaaggcgg
2926621 cgacacgcca acctggctga gcgtgcaaga ggacgacggg cgtctcgagc ttgcgatgtg
2926681 ggtgaaacgc accgatctgg gcttgcagcc cggtggccag cacgtgatcg acggcgtgac
2926741 gtttcaggag accgagcgcg gtcacgccgg atataccacc gagggcacga cgggcctgcc
2926801 ggccggcggt gagatggact acgtcgactg cgccagtgcc ggtcaggggg ccgacgagtc
2926861 catgctgctg tcattcgagc gctgggcacc ggacatggga tgggagatag cgaccggcaa
2926921 gtccgtactg gccggcgagc tcaccgtcta ccccgcgccc ccagtctcgg catagggccg
2926981 aatcggtgcc acttcatcag ctcgccatag cgccggtgga cgtatcaggg gcattgcttg
2927041 gactcgtgct gaacgcaccc gcgccgcggc cactggccac ccaccgactg gcccacaccg
2927101 acggcagcgc actgcagctc ggcgtcctcg gcgcgtcgca tgtcgtcacc gtcgagggac
2927161 gcttctgcga ggaagtctcc tgcgtggccc gcagccgggg cggcgatctg cccgagtcca
2927221 cccacgcacc cggctaccac ctccaatccc ataccgagac gcacgacgag gcggcgtttc
2927281 ggcgactcgc gcgccacctg cgtgaacgct gcacgcgggc aaccgggtgg ctgggcggtg
2927341 tgtttcccgg tgatgacgcc gcgctgaccg cactcgccgc cgaacccgat ggaaccgggt
2927401 ggcgttggcg gacttggcat ctgtacccga gcgcgtccgg cgggacggtg gtccacacga
2927461 cgagccgatg gcgtccatga gccgcaaccg cctgttcctg gttgccggca gcttggcggt
2927521 tgccgccgcc gtgtccttga tctctggaat cacgctgctg aacagggacg ttggctcgta
2927581 tatcgcctcg cactatcgcc aagaatcccg tgacgtgaac ggaacgcgat acctgtgcac
2927641 cggatcgccc aaacaggtgg ccaccacgct cgtcaagtac cagaccccgg cggcgcgcgc
2927701 gtcgcatacc gacaccgagt acctgcgtta ccgcaacaac atcgtgacgg tcggacccga
2927761 cggcacctat ccgtgcatca tccgcgtcga aaacctcagc gccggatata accacggcgc
2927821 atatgtcttc ctgggccctg gattcacccc tgggtccccg tcgggcggtt cggggggcag
2927881 cccgggcggt cctggcggca gcaagtaagg cgatgacgca aaggagagag tcatgtatta
2927941 ggccggagtc gatttcggga ccatcagcct taccccgatc ctgcatgggg tggtggccac
2928001 cgtcttgtac ttcctagtgg gcgccgccgt gctagtcgca ggctttctga tggtcaacct
2928061 gttgaccccg ggcgatctgc gtcgcctagt gttcatcgac cgccgcccca acgccgtggt
2928121 tctggccgcc acaatgtatg tggcgctggc catcgtcacc atcgccgcca tctacgccag
2928181 ctccaatcag ctggcccagg gcctgatcgg cgtggcggtg tacggaatcg tcggtgtcgc
2928241 gctgcagggg gtggcactgg tgatcctcga gatcgcggtg ccggggcgat tccgtgagca
2928301 catcgacgca cctgcgctgc atccggcggt gttcgctacc gccgtcatgc tgctggcggt
2928361 agcgggggta atcgccgccg cgttgtcatg acgtccaccc ggcaggcggg cgaagccacc
2928421 gaagcttcgg tacggtggcg ggccgtgctg ctggccgcgg tcgcggcgtg cgcggcctgc
2928481 ggtctcgttt acgagctcgc gctgctgaca ctggcggcga gcctgaacgg cggcgggatc
2928541 gtggccacct ccctgatcgt cgcgggctac atagccgcgc tgggagcagg cgccttgctg
2928601 atcaagccgc tacttgcaca cgcggccatc gcgttcatcg ccgtggaggc ggtgctgggc
2928661 atcatcggcg gattgtccgc ggcggcgctg tatgcggcgt tcgcgttcct ggacgagctc
2928721 gacgggtcga cgctggttct tgcggtgggc accgccctga tcggcgggct ggtcggcgcc
2928781 gaggtgccgc tgctgatgac gctgttgcag cgcggccgcg tggcaggggc cgccgatgcc
2928841 ggacgcaccc tggccaacct caacgcggcc gactatctgg gcgcgttggt cggcgggctg
2928901 gcctggccat tcctgctgct gccgcagtta gggatgatcc gcggtgcggc ggtcaccggc
2928961 atcgtcaatc tggcggccgc cggggttgtg tcgatcttcc tgctgcgcca cgtcgtgtcc
2929021 ggccggcaac tggtgaccgc cttatgcgcg ctcgccgcgg cgctcgggct gatcgccaca
2929081 ctgctggtgc attcccacga cattgagacc accggccgcc aacagctcta cgccgacccg
2929141 atcatcgcct accgacacag cgcctaccag gaaatcgtgg tcacccgccg cggcgatgac
2929201 ctgcgcctct acctggacgg aggtttgcag ttctgcaccc gcgacgaata ccgctacacc
2929261 gaaagcctgg tctacccggc agtctccgat ggcgcgcgtt cggtgctggt gctcggtggc
2929321 ggcgacggac tggcagcccg cgaactgctg cgccaacccg gcatcgagca gatcgtgcag
2929381 gtggaactcg accccgcggt catcgaactg gcgcgcacca ccctgcgcga cgtcaacgcc
2929441 ggttcgctgg acaacccgcg cgtacacgtc gtgatcgacg acgccatgag ctggctacgc
2929501 ggcgccgcgg tccccccggc tggcttcgac gcagtgatcg tcgaccttcg cgaccccgat
2929561 actcccgtgc tgggtcggct gtattccacc gagttctacg cactcgccgc ccgcgcgctc
2929621 gcgcccggcg ggctcatggt cgtgcaggca ggcagcccgt attcgacccc gactgcgttc
2929681 tggcgcatca tctccacgat ccggtccgcc gggtatgccg tcacgcccta ccacgtgcac
2929741 gtgcccacct tcggcgactg gggattcgcc ctggcacgcc ttacagacat cgcgcccacc
2929801 cccgctgtgc cgagcactgc ccctgcactg cgcttcctgg accaacaggt gctcgaggcc
2929861 gcgaccgtgt tttccggcga catccggccc cgcacgttgg acccgtcgac cctggacaat
2929921 ccgcacattg ttgaggacat gcggcacggc tgggactagc gcacccatct agggcggcca
2929981 gggtttgcac aacgcagcac gggttccgaa cggaaccggg gcccgctcgt agcccggcca
2930041 taaaagcata aaaacagtat gctgggtaaa tgaagaccac gctcgacctg cctgatgaac
2930101 tgatgcgcgc tatcaaggtc cgcgcggcgc agcagggccg caagatgaaa gatgtcgtga
2930161 ccgaactgct cagatccggt ctgtcccaga cgcacagcgg ggctccaatc ccaacgccgc
2930221 ggcgcgtgca gcttcccctg gtgcattgcg gtggcgcggc tacccgcgaa caagaaatga
2930281 cgccggagcg tgttgccgcg gccttgctcg accaggaggc ccagtggtgg tccggacacg
2930341 acgatgctgc tctgtgacac caacatctgg ctggcgttgg cgctttccgg acacgtgcac
2930401 cacagggcct cgcgcgcatg gctagacacc atcaacgcgc ccggagtcat ccacttttgc
2930461 cgcgcaaccc aacagtcgct ccttcggctg ttgacgaatc ggacggtgct gggcgcgtat
2930521 ggcagcccac cactgaccaa ccgcgaagcg tgggcggcct atgccgcgtt cctggatgac
2930581 gaccgcatcg tgctggccgg cgccgaacct gatggtttgg aggcccagtg gagagccttc
2930641 gccgttcgcc agtcgccggc gcccaaggtt tggatggatg cctacctagc tgctttcgca
2930701 cttaccggtg gattcgagtt ggtgacgact gacaccgcct tcacccagta cggcggaatc
2930761 gagctgcggc tcctggccaa gtgacagcgc aagccccgca gtgctcactc gtcgtcgagg
2930821 gcggccagca cctcgtcgga cacgtcgacg ttggtccaca cgttctgcac gtcgtcactg
2930881 tcttctagcg cgtcgacgag cttgaacact ttccgtgcgc cgtccaggtc cacgggcacg
2930941 ctgaccgagg gttgaaagct ggcctcggcc gattcgtaat cgatgccggc atcttgcaaa
2931001 gcgctacgaa ccgcgaccag ttccgcgggc tcggagatga cctcgaaact gtcgcccagg
2931061 tcgttgacgt cctcggcacc ggcttccaga acagccgcca gcacatcgtc ttcggtcaag
2931121 ccgttctttt ccagggtcac cacgcctttg cgggagaaca ggtaggacac cgaccccgga
2931181 tcggccatgg tgccaccatt gcgcgtcatc gccacccgca cctcgctggc ggcgcgattg
2931241 cggttgtcgg tcagacactc gatcagcacc gccaccccgt tgggcgcgta gccctcgtac
2931301 atgatggtct gccagtcggc gccgccggcc tcctcgccgg cgccgcgctt gcgggcccgt
2931361 tcgatgttct cgttgggaac cgagctcttc ttcgccttct gaatcgcgtc gtagagcgtg
2931421 gggttgccgg ccggatcacc gccaccgaca cgcgccgcca cctcgatgtt cttgatcagc
2931481 cgggcgaaca tcttgccgcg gcgggcgtcg acgacggcct tcttgtgctt ggtggtggcc
2931541 cacttggaat ggccgctcat cgcagtgatt tacctcttct gttgctcgtt cgccagacga
2931601 gtctacgtgg gggttgtggg cggcgagcca accggcacga gcagacacaa aagctccaaa
2931661 tttcggcctg aaacgggtgc ttttgcgact gctcacgccg cggaggtgac gatgtcgacg
2931721 aacaactgat gaatgcggcg atcgccggtc atctccggat gaaacgcggt ggcaagcacc
2931781 gcaccctggc gcaccgcgac gatgtgcccc gccgcgcggg ccagcacctg cacaccgtca
2931841 ccgactcgct caacccatgg cgcccggatg aacaccgcgc gcaccggatc gtctagacca
2931901 gcgaactcga tatcgccttc aaacgagtca acctgacttc caaaagcatt gcgccgcacc
2931961 gtcatattca tcgcacgcag gggcagcgcc tggcggcctg ccgcaccggc gtccaggatc
2932021 tcgctggcca acagaatcat gcccgcgcac gaaccatagg ccggaagccc atcggcgagc
2932081 cgggcccgca gcggtcccag caggtcgagg tcgagcagca ggtggctcat cgtggtggat
2932141 tccccgcccg ggatgaccag cgcgtccacc gcgtcaagtt cgtcgcggcg ccgcaccgtc
2932201 atcggctcgg ccccgcattc gcgcagcgca gccaggtgct cccgggtgtc gccctgcagc
2932261 gccagcaccc cgacccgtgg aacgctcaca gcccgctcac tgccccaccg accggtgacc
2932321 gcgccggtgg cgggtcagcc cctcctgcat gaccgccgcg accatctccc cggaccgtgt
2932381 gaaaatctcg ccccgagtca gcgcacgacc gccgctggcc gacggcgacg actggtcgta
2932441 cagcaaccac tcgtcggcgc ggaagggtcg catgaaccac atcgcatggt ccagcgatgc
2932501 cacctgcagc tggtcgcgca catcgaggtg gttgacttgt gccgatccca gcagcgtgag
2932561 gtcgctcatg taggcgagtg cacagatgtg caacaccggg tcgtcgggca acgggtcacg
2932621 gtggcgaagc cacacctgct gctgggaagc cttgcccggc aaaagccgca ggcgctcccg
2932681 gggcacgatg cacacgtccc actcgtcgaa ctgccggaac ccggcatcat cgaaaacctt
2932741 gatcgagttc aaccccggca ggccgtcggg cggcggcgcc gctggcataa cgtcttggtg
2932801 ggtaatgccc tcctgttcgg tctggaacga cgccgccatg ctgaatatgg tttccccgtg
2932861 ctggactgcg ttgacccgcc tggtgcagaa cgatccaccg tcgcggatgc gttcgaccag
2932921 aaaaaccgtg cgctccttgg catctccagg ccgaagaaaa tagccgtgca gcgagtgcac
2932981 catgtaccgc gggtcgacgg tgcgcaccgc cgacaccagc gactggccgg ctacatgacc
2933041 accgaaagtg cgttgcagga agcccgattc ggggctgaac acgcttcctc ggtagatgtt
2933101 gacctcaagt tgctcaagat caaggatctc ttcgatcgac acgcgatgac cgtctgctcg
2933161 tcgcgggttc tcaccagccg cgctgggcga gccgatgacc gacagcgatc tcgtccacgt
2933221 tgatgcccac catcgcctcg cccagcccgc gcgacacctt ggccagcaca tcgggatcgt
2933281 cgaagaacgt ggtggccttg acgatcgcgg cggcgcggtg ctcaggggcg ccggacttga
2933341 aaataccgga acccacgaag acgccctcgg cgccaagctg catcatcatc gccgcgtcgg
2933401 cgggcgtggc gatacccccg gcggtgaaca gtgtgaccgg caacttgccc gcccgagcta
2933461 cctcggcaac gagttcatag ggcgcttgca attcttttgc cgcgacaaac aattcgtcct
2933521 ccgacatcga cgtcaaccgg cggatctcac caccgatggc ccgcatgtgt gtggtcgcgt
2933581 tggagacgtc tccggtcccg gcctcgccct tggaccggat catggccgct ccctcgctga
2933641 tgcgcctcaa cgcctcaccg agattggtcg ccccacacac gaaaggcacc gtgaagttcc
2933701 acttgtcgat atggtgggcg tagtcagcgg gcgtcagcac ctcggactcg tcgatgtagt
2933761 cgacgcccaa cgtctgcagg atctgcgcct cgacaaagtg gccgatgcgc actttagcca
2933821 tcaccgggat ggtgaccgcg gcgatgatgc cctcgatcat gtcggggtca ctcatccgcg
2933881 acaccccgcc ctgggcgcgg atatcggcgg gcaccctttc caacgccatt accgcaaccg
2933941 caccggcgcc ctcggcgatg cgggcctgct ccggggtgac aacgtccatg atgacgccgc
2934001 ccttgagcat ctcggccatg ccgcgcttga cccgcgccgt accggtcgct gggttacctg
2934061 caggatccat ggtgcctcct cttgtcccca ctacgatacg accgctaccg cgccggtctg
2934121 ctagccactc aggggcgtgg ccaggacgcc gattggtaaa ttacgaatcc ctcagccgtg
2934181 cagcaccgga ggccggaatg gacgatgacg cccaaatggt cgcgatcgat aaagaccaat
2934241 tggcaaggat gcgtggcgaa tacggcccgg agaaggatgg ctgcggagat ctggacttcg
2934301 actggctcga cgacggctgg ctcacgctgc tgcggcgctg gttgaacgat gcacaacgcg
2934361 ccggagtgag tgaaccgaac gcgatggtgc tcgccaccgt tgccgacgga aaaccggtga
2934421 cccgttcggt actttgcaaa atcctggacg agtccggtgt cgcgttcttt accagctaca
2934481 cctccgccaa aggcgagcag ctcgccgtga caccatacgc atcggcaacc tttccctggt
2934541 accagctagg tcgccaggca cacgtacagg gcccagtcag caaggtcagc accgaggaga
2934601 tattcacgta ttggtccatg cgcccccggg gcgcgcagct gggtgcgtgg gcctcgcagc
2934661 agtcgcgccc ggtcggttct cgcgcccagc tcgataacca gctcgccgag gtgacgcgtc
2934721 gcttcgccga ccaggaccag atcccggtgc ccccaggatg gggcggctac cgcatcgctc
2934781 cggaaatcgt ggaattctgg cagggccggg agaaccgcat gcacaaccga atccgcgtcg
2934841 ccaatggccg gctggaacgg ttgcaaccct gatcgtcgag tctggccacc tcgcgggcga
2934901 agtttgacgg aacctcgcag atcttgccgg acatgccata gagtctttga ccggaatgcc
2934961 cgctgacccg tgacgacgcg gtcaccgggg atacccgccg cggtggtggc caaccgataa
2935021 cggccaaccg agaaagtaca cagcgatgaa tttcgccgtt ttgccgccgg aggtgaattc
2935081 ggcgcgcata ttcgccggtg cgggcctggg cccaatgctg gcggcggcgt cggcctggga
2935141 cgggttggcc gaggagttgc atgccgcggc gggctcgttc gcgtcggtga ccaccgggtt
2935201 ggcgggcgac gcgtggcatg gtccggcgtc gctggcgatg acccgcgcgg ccagcccgta
2935261 tgtggggtgg ttgaacacgg cggcgggtca ggccgcgcag gcggccggcc aggcgcggct
2935321 agcggcgagc gcgttcgagg cgacgctggc ggccaccgtg tctccagcga tggtcgcggc
2935381 caaccggaca cggctggcgt cgctggtggc agccaacttg ctgggccaga acgccccggc
2935441 gatcgcggcc gcggaggctg aatacgagca gatatgggcc caggacgtgg ccgcgatgtt
2935501 cggctatcac tccgccgcgt cggcggtggc cacgcagctg gcgcctattc aagagggttt
2935561 gcagcagcag ctgcaaaacg tgctggccca gttggctagc gggaacctgg gcagcggaaa
2935621 tgtgggcgtc ggcaacatcg gcaacgacaa cattggcaac gcaaacatcg gcttcggaaa
2935681 tcgaggcgac gccaacatcg gcatcgggaa tatcggcgac agaaacctcg gcattgggaa
2935741 caccggcaat tggaatatcg gcatcggcat caccggcaac ggacaaatcg gcttcggcaa
2935801 gcctgccaac cccgacgtct tggtggtggg caacggcggc ccgggagtaa ccgcgttggt
2935861 catgggcggc accgacagcc tactgccgct gcccaacatc cccttactcg agtacgctgc
2935921 gcggttcatc acccccgtgc atcccggata caccgctacg ttcctggaaa cgccatcgca
2935981 gtttttccca ttcaccgggc tgaatagcct gacctatgac gtctccgtgg cccagggcgt
2936041 aacgaatctg cacaccgcga tcatggcgca actcgcggcg ggaaacgaag tcgtcgtctt
2936101 cggcacctcc caaagcgcca cgatagccac cttcgaaatg cgctatctgc aatccctgcc
2936161 agcacacctg cgtccgggtc tcgacgaatt gtcctttacg ttgaccggca atcccaaccg
2936221 gcccgacggt ggcattctta cgcgttttgg cttctccata ccgcagttgg gtttcacatt
2936281 gtccggcgcg acgcccgccg acgcctaccc caccgtcgat tacgcgttcc agtacgacgg
2936341 cgtcaacgac ttccccaaat acccgctgaa tgtcttcgcg accgccaacg cgatcgcggg
2936401 catccttttc ctgcactccg ggttgattgc gttgccgccc gatcttgcct cgggcgtggt
2936461 tcaaccggtg tcctcaccgg acgtcctgac cacctacatc ctgctgccca gccaagatct
2936521 gccgctgctg gtcccgctgc gtgctatccc cctgctggga aacccgcttg ccgacctcat
2936581 ccagccggac ttgcgggtgc tcgtcgagtt gggttatgac cgcaccgccc accaggacgt
2936641 gcccagcccg ttcggactgt ttccggacgt cgattgggcc gaggtggccg cggacctgca
2936701 gcaaggcgcc gtgcaaggcg tcaacgacgc cctgtccgga ctggggctgc cgccgccgtg
2936761 gcagccggcg ctaccccgac ttttctaagc ggtccacaaa ccgtgcacgt cagcggatgg
2936821 gctgaggaac gccggcatcg cgcgcggctc cgttgtccag cgcgacgtcc accagccggt
2936881 tggctgccgg caacagctcg cctagttgca acgggtacac ccgctcgccc gccgccacca
2936941 gctgcgcgat gtcgttcgcg tcacaccagc gggcatcgcg aatatagcgg cgttccaact
2937001 cggttcgccc ctgcacagca ggctcgaacc gacgcgtccg gtgcaccagg tagaactcct
2937061 cgctgtcgat cagcgacccg ttgaactcga agacctcgtc gcgtcgccag ataggtccga
2937121 tcatgtcggc cggggccacc cgcagaccgg tttcttcggc cagctcccgg gcggcggcct
2937181 gggccagccg ctcacccggt cgcacttggc ccccgacggt gaaccaccac ttcggcgccg
2937241 cgccgtcccg aaacgccggg ttcgccggat ccgatccgca cagcaacaac acggcaccgc
2937301 tgtcatccaa tagcaccacc cgcgccgagg tgcggcgacc ggacgcaccc tgatcgccgt
2937361 gcaccaatgc gtggggtcgc tcgacgatct cgaaataggt tggcagcaca gcggttccac
2937421 caagccgcag caatcgcacc agccgtcgtt cccccagagc gagggtgtcg cgaacggcgt
2937481 cgttgtggaa gcggcgggcc agcaggacgc gggcttccgc gtcggctaac tcggcgatca
2937541 gggccgcggg cagcgacgcg gggttgacca tcgccaacgc ggccgaaagc tcgttctccg
2937601 cattctcgcg cgcatgccgg ggcgcgccct ccgcggcgtc ggctaaggcg gccagccgac
2937661 tgccctgggg ggcaccgccg tacgcgtcga tcgccaccgc acgtgccacc accgctcgtc
2937721 gcgcgagcgc gctgtccagc gactgccacg acaagtcata gcgcacgttc aaccggttca
2937781 accggttggc cgtctgatat ccccaggcgc cgaacgcaac cagcacaacg agcagcactg
2937841 cgccggccag gaccagccac gtcatcagct ggccacctga accttggcgc ccgacccggc
2937901 gaccgtctcg tacactcgca tgatctggct ggccaccacc gaccagtcat accggcggac
2937961 ggccgcgttg ccggccgcca catagcgctc ccgcaggaca tcgttctcca gcaccgcaat
2938021 cagtccatcg gccaacgcgg cggcctgcaa gtctggcggg tccaccggca ccaggtgccc
2938081 gacctcaccg tcgcgcagca cacgccggaa ggcgtcgagg tcgctggcca ccaccgcagt
2938141 gccggcggcc atcgcttcga ccagcacaat gccgaaactc tcaccgccgg tgttgggcgc
2938201 acagtagacg tcggcgctgc gcatcgccga agcttttccg gcgtcgtcca cctgacccag
2938261 aaagcgcagg tgcgccgcca aacggcccgc ctggccgcgc aactggtcgg cgtcgccgtg
2938321 gccgacgatc agtagctgga catccggaaa ccgctgcacc accttcggca gcgcgtcgag
2938381 caaaacggcc atgcccttgc ggggctcgtc gtagcgaccc aggaacaaca ccgttttacc
2938441 ctggcgcggg tacccgtcca gccgcgctgc cgaggcgaag gaatcaacgt ccaccccatt
2938501 ggggatctcc accgcatcgg atcccaacgc ctccatctgc cagcgccggg ctaggtcgga
2938561 caccgcgatc cggccgacga tcttctcgtg catgggccgc agaatgccct ggaacaccgt
2938621 cagcgtcagc gacttggtgg tcgaggtgtg aaatgtcgcc acaatcgggc cctcggcaat
2938681 gttcagggcc agcatcgaca ggctcggcgc attcggctcg tgtagatgca gtacgtcgaa
2938741 atcaccatgc gcaagccact ttttgacctt gcggtgggtc gccggaccga accgcagccg
2938801 ggccaccgag ccgttgtagg gaatcggaac cgccctacca ccggagacaa agtaatcagg
2938861 cagtgcggca tgcggggagg ccggcgcgag cacactgacc aagtggccgc gggtgcgcat
2938921 cacctcggca agctgtagca catgcgactg caccccgccc gggacgtcga acgagtacgg
2938981 acaaatcatg ccgatccgca tcaggctttc ctcatctgga cctcagttgc gcccgccgcg
2939041 attcggataa gtcggccagc cactggggct gcagcatgtg ccaatccgcg ggatgggcgg
2939101 caatgttctg cgcgaagcgg tcggccagcg cctgtgtgat ggcagcgacg tcaccgctgg
2939161 tgcaatccag cgccggatac acctggaaac cccagccgcg gccctcgaac cagcaatgtg
2939221 tgggcagcaa tgccgcaccg gtctcgaccg ccagcttcgc cggccccacc ggcatccggg
2939281 tgggctcgcc gaagaagtcg acctcaacac cggtgcgggt gagatcgcgc tcggccatca
2939341 ggcagaccac tcggttgttc ctcagccgct cagagagcac ctcgaacggc ggccgttcgc
2939401 cgccggacag cggcagcacc tcaaatccca ggctttcgcg gtagtcgata aagcgctggt
2939461 acagcgattc gggttttagg cgctcggcga cggtggtgaa ggtgccgtgc cgctgcacca
2939521 gccacatccc ggccatatcc cagttgccgc tgtgcggcaa cgccagcacg gcaccgaggc
2939581 ccgcggccag cgccgcgtcc aggtgatcca gtccaccgat cacgcggtcg agctggcggg
2939641 ccagcttgcg gtggtttatc gtcggcagcc ggaacacctc acgccagtag cgcccgtagg
2939701 actccagcga ggcgcacatc agcgggtccg gcaccgcggc tggcggcaca cccaggacgc
2939761 gggccaggtt cttgcgcagc tgctcgggcc cgccgtggcg ggcaaagtag cgcgctccgg
2939821 tgtcgaatgc gttgcgtacg gcgaactctg gcagcgcccg tacggccatc cagccggccg
2939881 catacgccca gtcggtcgcg gtgcgcgtca cggaactgcg cggatctttg ggcagcttca
2939941 agcccttaag gccggcaatc accggtcgcc ctttccagga atcgccatcc gatcgatggc
2940001 tccgggtgaa gtccagaccg tgtgcaaccg ctgcacgcag gtgatcacgc tggcgacggc
2940061 cagcagccac atccccaccg acaacgccgg cggccagggc acaaacggga agtccgacac
2940121 cccggcgccg gtcagcacga tgatcaaccg ttccggccgt tcgatgaagc cgccgtcgcc
2940181 gcgcagcccg ctggcctccg cccgggcctt gatgtaagag atcacctgcg aggtgaccag
2940241 acagatcaag gtcgcgatca ccagcggtcg gtcgcgcatg tgaaacgcta tccaccacag
2940301 cagaccgcag aacaccgcgc cgtcactgat gcggtcacag gtggcgtcca gcaccgcgcc
2940361 gaagcgagtg ccgcccccgc gctcccgggc catcgccccg tccagcatgt cgaacaacac
2940421 gaagaaccac accacacacg cacccgcgaa cagcttgccc atcgggaaca gcgtcagcgc
2940481 tcccgccacc gacgcggtgg tgcccaggat ggtgacgacg tccggcgtga ggccgacccg
2940541 cagcagtccc ctggcgatcg gggtggtaat ccgggcgaac gccgcccggg acaggaaggg
2940601 cagcttgctc atggttgccg agcccactcg gtggcaagca gccgacgggt gtcgcgcagc
2940661 agctgcggaa tcaccttgga gcccccgatg atggtgatga aattcgcatc gccaccccac
2940721 cgtggcacca catgcacgtg caggtgctcg gccagcgacc cgcccgccga tgtccctagg
2940781 ttcaggccga cattgaagcc gtgcggacgc gacacgttct tgatcacgcg aatcgccttc
2940841 tgggtgaacg ccatcaactc ggcgctctcc aaatcggtga gatcctcgag ttcggatacc
2940901 cgacgatagg gcaccaccat caagtgcccg gggttgtacg ggtacaggtt gagcacggcg
2940961 tagaccagct tgccacgagc gaccaccaga ccctcttcgt cggacagctg cgggatctcg
2941021 gtgaacggct gcgcagggct ggccgaggaa ttggggtcac gcttcactgg cgcttcggcc
2941081 aggtagttca tccggtaggg ggtccataac cgctgcagct ggtcgcgctg gccgacaccc
2941141 cgatcgaaga tggtgtggtc ctcggtggcc cgatccgtgc ggtcctcgtc actcacgacc
2941201 ggccactttc accagttccg ctgtaggaac cgcattttcg cggtcagcga tccaggcgac
2941261 aatggccgcc accgcatcgt cacgggccac accgttgatt tgggtgcggt caccgaaccg
2941321 gaaactcacc gcgccggcgg cgacgtcacg atcacccgcc aacaccatga acggcacctt
2941381 gtggttggtg tggtgcacga tcttcttggc catccgatcg tcgctggcgt ccacctcggc
2941441 ccgcaccccg tgcgacttca gttgcgtggc aacctcttcc agataggcga cgtgctcatc
2941501 ggcgaccggg atgccgacca cctgcacggg cgccaaccag gccgggaacg cccccgcgta
2941561 gtgctcggtg agaatgccga agaaccgctc gatcgaccca aatagcgcgc ggtggatcat
2941621 caccgggcgg tggcgggttc cgtcggcggc ggtgtactcc aggccgaaac gttccggaaa
2941681 gttgaagtcc agctggatgg tcgacatctg ccaggtgcgg cccagcgcgt ctttgacctg
2941741 cactgaaatc ttgggcccgt agaacgccgc gccgcctgga tcgggcacca gctccagccc
2941801 ggattcggcg cccacctcgg ccagcacggt ggtggcttcc tcccagacct cctcggcgcc
2941861 gacgaacttc tccgggtcct tggtggacag ttcgaggtag aagtcggtga ggccgtagtc
2941921 ggcgagcagg tcgagcacaa accgcagcag cgaccgcagc tcgtcgcgca tctggtcgcg
2941981 ggtgcagaag atgtgcgcgt cgtccatggt cagcccacgc acccgggtca acccgtgcac
2942041 cacaccggac ttctcgtagc gatacaccgt gccgaactcg aagagccgca acggcagttc
2942101 ccgataggat cgcccgcgcg cgcggaagat caggcagtgc atcgggcagt tcatcggctt
2942161 gaggtagtag tcctggccgg gtttgcgcag cgagccgtcg gcgttgtact ccgcgtcgat
2942221 gtgcatcggg gggaacatgc cgtcggcgta ccagtccaga tgtcccgagg tgtggaacaa
2942281 ctgggccttg gtgatgtgcg ggctgttgac gaactggtag cccgcctcgg tgtgcttgcg
2942341 ccgcgagtag tcctccagtt cgcgacgcac gatgccgccc ttggggtgga aaaccgctag
2942401 gccggaaccg atttcgtcgg ggaagctgaa caggtccagc tcgacaccca gcttgcggtg
2942461 gtcgcggcgc tgcgcctctt cgatgaactc caggtgcctg tcgagcgcct cctgggattc
2942521 ccacgcggtg ccgtagatcc gttgcaggct ggcgtttttc tgatcgcccc gccagtaggc
2942581 ggccgagctg cgggtgagct tgaacgccgg gatgtgtttg gtggtcggga tgtgcggtcc
2942641 gcggcacagg tcgccccaga cgcgctcgcg ggtgcggggg ttgaggttgt cgtaggcggt
2942701 gagctcgtca ccgccgacct ccatgatctc ggcgtcaccc gatttgtcgt cgacgagttc
2942761 cagcttgtag ggctcgttgg ccagctcggc gcgggcctgt tcggtggatt cgtagacccg
2942821 ccggtcgaac agctggcctt ccttgacgat ctggcgcatc cgcttttcca gcgccgccaa
2942881 gtcctcgggc gtgaacggct cgggcacgtc gaagtcgtag tagaagccgt cggtgatggg
2942941 tggtccgatg ccgagcttgg cctgcggaaa cagctcttgg acggcttggg ccaacacgtg
2943001 cgcggtcgaa tggcggatca cgctgcgacc gtcgtcggtg ttggcggcca ccggcgtgat
2943061 atcggtgtcg acgtcgggca cccagctcag gtcgcgcagg ttgccgtcgg cgtcgcgcac
2943121 gacgacgatc gcatcgggcg taccgcgccg cggtaaaccc gcttcgccga cggcggtggc
2943181 cgcggtggtc ccggcaggaa cccgaattcg ggcttgcgac gggtcgccgc catcgactcc
2943241 cggggcgggt tgtgcggggg cgctcatcgg gtcggtctcc aaggcttgga cgtgtcgaaa
2943301 cgatcgcgac catgctatcg gggcgcacgt cgacgaccgt aagccgagtg accggatggg
2943361 ttttcgatca ccggtgtggg cgatcggtac cgggcaggtg accgggtgct ctacggcggc
2943421 tcgatgagcc caaaggatgt tgacgacctg gctacccagc aggacgtcga cgacggacag
2943481 tcgatagagc gtcgctggac ggggagcggt cagcgacgct ggcggcggtc gccgccgacg
2943541 ggccgctacc gtagcaactc gcaaatccag gtctggattt ccggcgccgg ccggctccgt
2943601 tagccgtcgg ctccgttggt gccggccagg ccgggtggcc ccaacagtga tgcaccgccg
2943661 ctgccgccgg gcccgccgaa gcctggagcg ccattgaaga ggctcccggc gccgccgttt
2943721 ccgccgtttc caccgttgcc gatcagtccg acgctgccgc cgttcccgcc tttcccgccg
2943781 tcaccgccgg acccgccagc agtgccggcg ctcgctccgt tcccgccggc cccggcgctc
2943841 ccaccggccc ccgcgttgcc gatgagggca ttgccgccgt ttccaccgct gccgccgcta
2943901 ccgccattcc ctccgaaggc cgtaacagac ccgggcgacc cggcggcacc gccgtttccg
2943961 ccggccccgc cgttaccgta gagtagcccg ccggcgccgc cgttaccgcc ttgcccgcca
2944021 aacccaacgc ccccgaaatc ggcggacaca tcaccaccgg ctccgccggc tccgccattg
2944081 ccgccgttgc cgatcagtcc ggtggttccg gcgtgaccac cgttaccccc gaatccggac
2944141 gctggaccgt tctgagaaat gcctgccccg tttccggcgg ccccgccgtc cccgctgttg
2944201 ccgatcagta ggccgccgtt cccgccgttc ccgccgttgc cgccgctagc ccccgcggag
2944261 ggctcgccgc cgccggtgcc cccggccccg ccggtcccgc cggcgccgat cagcccggcg
2944321 ttgccgccgt tcccaccatg cccgccgata gcgaggttgg tgccggcccc accgatcccg
2944381 ccgttcccgc cggccccgcc gttgccgaac agccatccac cggcgccgcc ggctccgccg
2944441 ttcgcgccgg cctcaaaggg taggccctgg ccgccagctc cgccggcccc accgttgccg
2944501 atcaacccgg ccgcaccgcc ggccccgccg gcctgcccgg gtgcccccga cccgccgttg
2944561 ccgccgttgc cccacagcca cccgccgtta ccgccggctt gcccggtccc gtcgatcccg
2944621 ttcgcgccgt cgccgatcaa tgggcgcccg gtcagcgact gaacgggtgc gttgatcgca
2944681 tcgagcacgt tctgcagcgg tgttgcgctg gccgcttcgg cgaccgcgta ggtgctgcca
2944741 gcttggctta aggccagcac gaaccgttgc tgataggccg cgacctgcgc gctgatcgct
2944801 tgatagtgct ggccgtggct gccgaacagc gcggcgatcg ccgttgacac ctcgtcttgg
2944861 gcggcggcca acacctgggt ggtcgccgcc gccgcggtgt tggcggtgtt gatcgccgag
2944921 ccgatccgcg ctgcatcggc cgcggctgtg gacactaact gtggggccac gttgacaaac
2944981 gacatcgaaa tcctcctgac cgccacgatg ttgagatgcg ggcggcccac cgcctgttac
2945041 cgccgcggtg ggtaaccgtt tattcggacg atccctgccg ttccacgcct gggcgcaggc
2945101 acaaaccgca ccaacattgg tggaacgtgg tgcacactgc acctggggtt ctgccctcat
2945161 cgtgtggcag caggcgaaac ccgcgcggac gagaactctt ccgccaagca gcacaaatcg
2945221 ccctacaccc cagtgaatct ccggacgcca ctacgacagc gcgcaacggt cgcctcatcg
2945281 actgtgtgca cgcgcgcttc gcgatgcgct gccgtggcaa gctggccagg tggacctcaa
2945341 tgcgctggcc gatctgccgc tgacctatcc ggaggtgggc gcgacagcga ccggacgact
2945401 gcccgcgggc tacaaccacc ttgacgtgtc gacgcagatc ggcaccggcc gccagcgttt
2945461 tgagcaggcc gccgacgccg tcatgcattg gggcatgcag cgcaacgccg gcctgcgggt
2945521 gcgggccagc tccgaaaccg ccgtcgtgtc cgcggtggtg ttggtgggaa tcgctttcct
2945581 gcgtgcgccg tgccgagtgg tgtatgtcat cgacgaaccc gacgtgcgcg gattcggtta
2945641 cggcactttg ccgggccatc cggtgtccgg cgaggaacgg ttcgcggttc gctgcgaccc
2945701 gatgacctcc gtggtgtttg ccgaggtgtt gtcgttctcc cgtccggcga cctgggcgag
2945761 caaagccgcc gggccgctgg gcgcggtgac ccagcgcttc atcgcccagc gctacctgcg
2945821 cgcggtgtga ggcgccggcg ccctggttaa ggccgcccga tgcctccgct gtgcacgccc
2945881 tgcgccagcc gggcgagcgc gatggcgcca accagcaaac cgaagtcgcg cagcgcgatg
2945941 tcgtagaaac cgggtccggt gaccaggttg agaatgatcc cggccagcca ggccgcgact
2946001 acccaggcgc cgatgcgcgg tgcgaccgca accaatacgc cggccacaat ctcgattgcc
2946061 ccgaccaagt acatgcattg gtcggcggtg ccgggcacga gatcgttgat ccagccggcc
2946121 agatacatgt tccagtgctg cggatgggtc agcagattga agaacttgtc cagcccgaac
2946181 aggatgggcg cgaccgtgaa cagcgtgcga agcaatacgt atgcagagta tgccggatcc
2946241 ttcagctggt ctgcgagagc agggctggtc gttggtctga tgctcatagc tgcctcccga
2946301 cttctaacag acaacaattt gaacgttaga tcctatagac tgtatcgtca agtgttttgt
2946361 ctgttagaga tggcttgctg aagtggacgg ccgagcttcc ttcgaacgcg acgtcgccgg
2946421 gatcggggca ctcgtggatc cggtgcgtcg ccagctctac caattcgtgt gctcacaatc
2946481 gatgccggtg agccgagacc aggcggccga cgccgtcggc atcccgcgcc accaggcgaa
2946541 attccatttg gaccggctca ctgccgaagg cctgctggat accgagtacg cgcgcctgac
2946601 cggccggtcc ggccccggcg ccgggcggac cgccaagctg tatcgccggg ccggccgcga
2946661 catcgccctc agccttccac agcgggagta cgagcttgct gggcggctga tggccgcagc
2946721 catcgtgctg tcggccacca ccggggagcc gaccgtggaa gtgctcaacc ggatcgccca
2946781 tgactacggc caagccatgg gcgccgccgc caccacccgg ccgcccgcag accccgcggc
2946841 ggcgctggag ctgacgctgg atgtgctgcg caagtacggt tatgaacccc gccgcccggc
2946901 tggccctggc gacgatgagg tcgagctggt gaactgcccg ttccacgcac tggcccggga
2946961 gcagaccgag ctggcctgca atatgaacca cgccttgatc acaggcgtgg ccgacgcgct
2947021 ggcaccgcac agcccggccg ttcggttggc acccggaccg gcccggtgtt gtgtagtact
2947081 caagcgatgt tcggctcacg accccgagtg agcatcgggc agggatttca gcacggtcag
2947141 catgatcacc gaatcctcga cggcgtgcag cgcatgccgt gtcggcggaa tcgcgacgta
2947201 gtcgccggcc ctgccgttcc acgcgtcctc accggcggta aggcacacat ggccctgcag
2947261 cacttgcagc gtcgcctcgc ccgggctgtc atgctcggac aggtcgtggc cggcaagcaa
2947321 tgccagcacc gtctgccgaa gctcgtgggt gtgaccaccg tggatggtgt gggcagcccg
2947381 tccgctgtgt gtctgttgcg cctcggccag cttttcggcg gccaggctgg tcagcgaaat
2947441 ggattccatc ggcgcgtcct ttcagccgtt cagtagcagt atccccgcga cgagcaacgc
2947501 aaccaccttg actatctcca aaccgacata gatgtggtga ccgcgggagc ggggagcctg
2947561 cagcccggcc aatacctgat tggaccgtcg agtcaatcga ggacgcaccg caatcaactg
2947621 gacggccaac gcagccaacg cgaccgaaaa cgccgcggcg atccgcgccg gcgtcgagcc
2947681 gaccaccacg atcgcgagga tgacaagggc gaaaccgacc tcaacggtat tgagcgcacg
2947741 gaagaccaac cggccgatgc cgagcccgat ctgcagcgtc actcctgccg cccggaactt
2947801 cagcggagct tccagaaacg agatcgccac caccattccc agccagacga acgcgacggc
2947861 gacctcgatc gccggtccgg cgctcaccga atggctcctt ccagcggcgt gaagtgggcc
2947921 aggcacaggt cgggttcgac gaacgcgtcg agccggtcga cggtgactgg cgccccccat
2947981 gtttgcaagg ctccccgcat gatccctaag tggacggggc agacgacacc ggcttgagtt
2948041 tcggcgagtt ccagaaacgg acagtgccgc agaccgacct gttgcctgcc gttggatgcc
2948101 cggcgctcgg gagcgaagcc aaggtcgtca agcaccgcga ccaagtggtc gatcgtctcc
2948161 tcggtgtcgg caccggccgg cggcgcttcg agctggcgcc cccacgcccg gcccgcggac
2948221 aacgccatgg cccgcgaatc ccgttcggcg gcaaggccac tggcgaggat ctcggcaagc
2948281 agccggtaac gccgcgtccc agtgctatcc gtccgccgga ccgcccgaaa catcagcggc
2948341 gggcgccccg gtcggccgcg gccgggctcg acccgctcca cctggccatc agcgaccagg
2948401 ttatcgaggt ggaagcggac ggtgttggga tgcacgccca acttgccggc gatcgcggcg
2948461 atgctcatcg gaacccgcga cgcacacaat gcccgcagca ccgcacgacg gcgccccacc
2948521 ggctcttgca gtgacctgat gatgacactc acccccataa ggctcgtcgg ctgcgcctga
2948581 gcaatgcagt aagtttacac aaacggactt gtaaaaacct gcggaggtgg ggtctatggc
2948641 caacaaacgt ggcaatgccg ggcagcctct gcccttgtcg gatcgagacg acgaccacat
2948701 gcaggggcac tggctgctgg cccggctggg caagcgggtg ctgcgtcccg gcggcgtcga
2948761 actcacccgg acactgctgg cccgcgccga ggtgaccgac gccgacgtgc tcgagctggc
2948821 accgggcctg ggccgcaccg cagccgaaat cttggcccgc aacccgcggt cgtacgtggg
2948881 ggcggagagc gatcccaacg cggccaacct ggtccgacac gttctcgccg gccgcggcga
2948941 cgtccgggtc accgacgcgg ccgataccgg attatccgac gccagcgccg atgtcgtcat
2949001 cggcgaggcg atgctgacca tgcaaggcaa cgcggctaaa cacacgatcg tcgccgaggc
2949061 ggcgcgggtg ctgaggccgg gtggccgcta cgcgattcac gaactagcgc tggtgccgga
2949121 cgacgtcgca gagcaggtcc gcaccgacct gcggcagtcg ctggcccgcg cgctcaaggt
2949181 caatgcgcgt ccgctgaccg ttgcggaatg gtcgcacctc ttagcgggcc atggactggt
2949241 cgtcgaacac gttgtcaccg cttccatggc gttgttacaa ccgcgacggg tgatcgctga
2949301 cgaaggcctc ctgggtgcgc tgcggttcgc cggaaacctg ctcatccatc gtgccgcgcg
2949361 tcggcgagtc ctgttgatgc gccacacatt ccgcaggcat cgtgaacgct tgacagccgt
2949421 cgccattgtc gcgcacaaac cgcacgtcga ttcgtgatcc attgaggacc taagcccgtt
2949481 gggctagtga caaacgcctc ctgagcaaaa ccctcctccc ccgttaccgt cgtgcggtag
2949541 ggacaagcca catcggccga gcgggcgatc agccaacgac aggaggaccg cgatgtcatc
2949601 gggcaattca tctctgggaa ttatcgtcgg gatcgacgat tcaccggccg cacaggttgc
2949661 ggtgcggtgg gcagctcggg atgcggagtt gcgaaaaatc cctctgacgc tcgtgcacgc
2949721 ggtgtcgccg gaagtagcca cctggctgga ggtgccactg ccgccgggcg tgctgcgatg
2949781 gcagcaggat cacgggcgcc acctgatcga cgacgcactc aaggtggttg aacaggcttc
2949841 gctgcgcgct ggtcccccca cggtccacag tgaaatcgtt ccggcggcag ccgttcccac
2949901 attggtcgac atgtccaaag acgcagtgct gatggtcgtg ggttgtctcg gaagtgggcg
2949961 gtggccgggc cggctgctcg gttcggtcag ttccggcctg ctccgccacg cgcactgtcc
2950021 ggtcgtgatc atccacgacg aagattcggt gatgccgcat ccccagcaag cgccggtgct
2950081 agttggcgtt gacggctcgt cggcctccga gctggcgacc gcaatcgcat tcgacgaagc
2950141 gtcgcggcga aacgtggacc tggtggcgct gcacgcatgg agcgacgtcg atgtgtcgga
2950201 gtggcccgga atcgattggc cggcaactca gtcgatggcc gagcaggtgc tggccgagcg
2950261 gttggcgggt tggcaggagc ggtatcccaa cgtagccata acccgcgtgg tggtgcgcga
2950321 tcagccggcc cgccagctcg tccaacgctc cgaggaagcc cagctggtcg tggtcggcag
2950381 ccggggccgc ggcggctacg ccggaatgct ggtggggtcg gtaggcgaaa ccgttgctca
2950441 gctggcgcgg acgccggtca tcgtggcacg cgagtcgctg acttaggttc agcggcgaac
2950501 gacaagcacc gaacactcgg cgtgacggaa caccggatgt ccggatggcc cgaccagccg
2950561 cgctagctga ccggcctcac caccgccgat cactgccagc tgtacgcgct cgtcgtggtc
2950621 ggccaggaac cgggcaatac ccgtgtgagt ggtgatcggg tagacgcgca catcgggatg
2950681 acggtggtgc caatcctgca cgcgacgttc gaattcgccg tccggaatct cccggagctc
2950741 ctccggtcgc ccgccgagtg ccagtatggg cgcttgccgc aacttcgctt cccgggcagc
2950801 gtattccagc acggcctcgt tatccggtgc gtcggtcatg cgcaccacga tccagttgat
2950861 gtcagacgct ggctggtcca cttttgagcg catgacggcg accgggcaat gcgccttttc
2950921 ggccagctcg gttgccgtcg aacccaagat cgagctggcg tagcgcccga ttcccacgga
2950981 gccgacgcag atcatctcgg cgtcgcgcga tgcctccaca agcaccgggc cggctggccc
2951041 gcgggggatg tcggtttcga tcttgacgag cttgcccgcg gcctcaacag cggactgcgc
2951101 ttcccgaagc gatctttcag catgcgcaag gtcgcggtcg tagtcgtccg gggacggatg
2951161 tgtcggcttg atcactgaga ccagtcgcag cggcaccgct cggctgatgg cctcgtcaac
2951221 cccccacaat gcggccgtaa tcgccgcgtg cgaaccatcg ataccaacaa tgattgtttt
2951281 catcgtcggc tctcctctcc cagacatttc ccgatgctcg atcaccccgc atcggaaaac
2951341 ctgtccgcat cttggggact cgtggtaaag gtcggttccg gctgggccaa ccggtagacg
2951401 tcaatcagcc gcgcgacatc gctgggagtg acgatgccga ccaccgcgct cccttcggtg
2951461 accagcgcac ggctgcgcgg gccgagcggt gccatccgct ctaggagcgc ggtcagcggc
2951521 tcttgtggtc gggcggtcgg cacgctgtgc agcggcagcg caatgtcacc tacgctggta
2951581 gtgctgcgcc ggctaggcgc aacatcgcgc agctgccgca atgccaccag gcccgtgatc
2951641 gatccgtccc gatcggcaac cggatatgcc gagtgccgtt caccaagcac gtaacgctgg
2951701 atgaaatcct cgacattgat ccatccggga gccgtatgcg gttgggcggt catcgcatcg
2951761 gccacacgca ccccggcaaa cagctgctgg gtcgaaatcc gggtctcctc ctcgcgagcg
2951821 gcagcgaaga taaaccagcc aatgaaggct aaccagaccc caccgacgag gccaccagcc
2951881 acaaactcgg ccaatcccaa cgcgatcaag accagcgcaa ccacccgtcc ggcccgcgcc
2951941 gcaccgatcc cggcgcgcac actatcgccg tggcggcgcc acagataggc ccggaccaac
2952001 cgcccaccgt ccaacggcgc gccaggcagc agattgaaca gccccagcag caggttgaca
2952061 gtagccaacc accaagcaac gctgatcacg atggccgggg tccgcacgcc ggcgagcgtg
2952121 atggccaacg caccgaatgt cgccgacagc gccaggctgg tagccggacc cgcgaacgcg
2952181 atccggaaag cggctttggg cgtctttgcc tcgccgccaa gcgcggtcac cccgccgaac
2952241 agccacaacg tcacgctctc aacggatacc ccggcgcgac gagcgacgac ggcgtgcgcg
2952301 agctcatgag ccaacagcga cgccagcaac atgaccgcgc cacctgcgcc gagaagccaa
2952361 tagaccacgg ccgggtagcc tccgacggta cccggcaaca tggtcgccag actccaggtg
2952421 aacaaccaca ggatcaccaa cacgctccag tggacgttca ccacaaaccc ggcgatccgc
2952481 ccaagcggga tcgcatcacg cattgggtac ctccgatgct ggcggataaa gcctttcgtg
2952541 ccggcggatg atccgaggtc gctagctggc gagggccatg ggcgagcaga ttgccttgac
2952601 gaactgcaca atggcgtgct cgggcaggtg tcgggcgatg tcggcttcgg tgacgattcc
2952661 gaccaagcgg tgctctgaga tgaccggaac acggcggacc tgatgttctt ccatgacgtt
2952721 gagcatctcc tggatgcttg cgttcgcatc gacgtagtag atgctgtccc gggccaactc
2952781 gccagccgtg gcggtattcg ggtctaggcc cgcagccagg cctttgatca caatgtcgcg
2952841 gtcggtgagc atgccgtgca gccggtcgtc gtccccgcag atcggcaacg cgccgatgtc
2952901 gtgctcacgc atgtattgag cggcagcggt tagcgtctcg tgttcgccaa cacaggtcac
2952961 acctgcgttc atgatgtcgc gtgcggtggt catcgggatc ctcctcgagt cggggtgcta
2953021 ttgctgatct gctgccgaag gtacgaccac gtcgtagcga acactagggt cgtttgaccc
2953081 gtgggccgcg ggtcgatgga cccgtactgg cgcgcgttga ggcagctggc ttgcctggct
2953141 tgtcctcgcc gtaggccacc tcaaagtcga aggttgtcaa ttgatttcac cagccggata
2953201 tagcgctatg ggcggccgca ggaccgatag tgatgccgat cggccccgat cggggtaacc
2953261 ggcaatggaa caactgacaa ccatgaaggc tcgtttcgac ggaagcggaa gacgccgaca
2953321 ggcacatgag cctcgcgacg gggccaatcc gttggctttg cgaccgtggt cgtaggtcct
2953381 ggcggagccg ggttgccaca tccgtcacaa gctgacacgc cgaacgtgca accagggcgg
2953441 catcgcctgg gtgtgtctcc gccaccagtg cacattcggc gcagccagcc cacgctcggc
2953501 gcggagttag gcggaacggt cgcgctgtgt ccgtggcgcg tccaacaggc ccgactgctc
2953561 cagcgcagcc tggacaaacc gtcgtaccgg ccgcgactgg aagaagccag tgtgaccgcc
2953621 tggataccac acgatttcgg gtttgcccca gtgctcccag aggcgagtca cctgttcgcg
2953681 tggatgcacg agtcggtcgg caatgcccgc gtagataaag cggcccggca tgggcaccag
2953741 tggcgtaagt gagagcggcg agatcattcg gccgatcggt tcggccatct tgacggtgtg
2953801 gcggcggggg tctttgtgcc gaagaccgca gtggcggccc aacaactcga tcagatcagc
2953861 cactgggaca ccgagaatcg cgcaggcgag accttcttcg aggctggcga ccaatgacgc
2953921 gatgtagccg cccagcgaga gaccgttcaa cccgatcagc gactcctcct cctgcgatcg
2953981 tatccaggac aacagccgcc ggatatccca caccgcttga gccgtcccat gcacatcgtc
2954041 gagaacatct tctccgggaa aaacggcgcc cttcggcaga ccttgcccgc ggggaccatg
2954101 catcggaaga accggcatga caatgttcag gccgagttcg tcatgcagct tccaggcgcg
2954161 gaacaccgcg agatccaacg gggccctgcc catctcggtg ccgtgtacac aaaccagcca
2954221 gggacgcggc tctgggtgcc gcagtaacag ggcgtactcg cgattgttcg cagtgtatga
2954281 gagccaccgt tggctgcccg gttcacccgg atgcggcgta aacccactgt cgaagaagat
2954341 gcgataaaag gagcgtctgc ggtccttgac ctttcggacc gcgacctcgg tgagcggtgg
2954401 gggctgggca aaaaatccgc taggcttctc cagccatctg cgattcccat agaactccag
2954461 tccagcggcc acttcttggc tgatgcgctc gaacactcga tgattgctga ccggacgtcg
2954521 tgccttgagg cccagcagga cgatttcgtc tcgaaaggct tgcgccgcta aggcaatagt
2954581 gggccgtgcg atcggcagtt tatcgggctg ttgacccaga tagtcgcgcc acgattgagc
2954641 gacgtacaga ccggtgtgca tgaacggtcc catggcgccg ctcaagaccg gtggactcag
2954701 gcgaaaagcc gagcgttcgt gggtgccgtc gctcgcagaa cttgccatgg cagcaaagct
2954761 aaccgcgtgc ggaacgacgc gttagggact tacgtcccgc cggaagtcac ctgtgtggtg
2954821 gtggccactg tcgagaccgg cggcccgttg tggtggccca agtgccctaa ggtgatcagg
2954881 tgccgcagcc cggccagcac gccgtcagag tttcacgggg cttggtcgcg gccgatggcg
2954941 tcctcatcgt ggggtcgatg accgaggtgg acgcggcgcg accgggcaca tcgacggtcc
2955001 ccggggcttt gtgggccagt gaagtgacga aagaccccag tggacacgga cttcggcatg
2955061 tccacgcaac gaccgaggca ctccggtatt cgggctgttg gcccctacgc atgggccggc
2955121 cgatgtggtc ggataggcag gtggggggtg caccaggagg cgatgatgaa tctagcgata
2955181 tggcacccgc gcaaggtgca atccgccacc atctatcagg tgaccgatcg ctcgcacgac
2955241 gggcgcacag cacgggtgcc tggtgacgag atcactagca ccgtgtccgg ttggttgtcg
2955301 gagttgggca cccaaagccc gttggccgat gagcttgcgc gtgcggtgcg gatcggcgac
2955361 tggcccgctg cgtacgcaat cggtgagcac ctgtccgttg agattgccgt tgcggtctaa
2955421 gcaccaccta acggtgtcgt cccgaaggga cgattgccga tccggtggat gactttggtc
2955481 cctatgcctt cccgctggac cgcacaacga tcgaaggtgc cacgacgcat agaagacatg
2955541 gccatgccac accctgatag cattgcagca agctacatgt actgctctac caggatcctt
2955601 atgggcaaca gtgggtttga gttatgaaac ccgtgggcac atacccttcc gcgtcgtact
2955661 ggtcagtctc gacagcgaag agatcaccgg ttgatccacc aagcatgcat tggcgggcat
2955721 ctgcataaac ggtgacgtat cagcacaaaa cagcggagag aacaacatgc gatcagaacg
2955781 tctccggtgg ctggtagccg cagaaggtcc gttcgcctcg gtgtatttcg acgactcgca
2955841 cgacactctt gatgccgtcg agcgccggga agcgacgtgg cgcgatgtcc ggaagcatct
2955901 cgaaagccgc gacgcgaagc aggagctcat cgacagcctc gaagaggcgg tgcgggattc
2955961 tcgaccggcc gtcggccagc gtggccgcgc gctgatcgcg accggcgagc aagtactggt
2956021 caacgagcat ctgatcggcc caccaccggc tacggtgatt cggctgtcgg attatccgta
2956081 cgtcgtgcca ttgatagacc ttgagatgcg gcgaccgacg tatgtatttg ccgcggttga
2956141 tcacaccggc gccgacgtca agctgtatca gggggccacc atcagttcca cgaaaatcga
2956201 tggggtcggc tacccggtgc acaagccggt caccgccggc tggaacggct acggcgactt
2956261 ccagcacacc accgaagaag ccatccgaat gaactgccgc gcggtcgccg accatctcac
2956321 ccgactggta gacgctgccg accccgaggt ggtgttcgtg tccggcgagg tgcggtcacg
2956381 cacagacctg ctttccacat tgccgcagcg ggtggcggtc cgggtgtcgc agctgcatgc
2956441 cggaccgcgc aaaagcgcct tagacgagga agagatctgg gacctgacat ccgcggagtt
2956501 cacccggcgg cggtacgccg aaatcaccaa tgtcgcacaa caatttgagg cggagatcgg
2956561 acgcggatcg gggctggcgg cccaagggtt ggcggaggtg tgtgcggctc tgcgtgacgg
2956621 cgacgtcgac acgctgatcg tcggagagct aggcgaggcc accgtggtca ccggtaaagc
2956681 gcgtactacg gtcgcgcggg atgccgacat gttgtccgaa ctcggcgaac cggtagatcg
2956741 cgtggcaagg gccgatgagg cgttgccatt cgccgcgatc gcggtaggtg ccgcattggt
2956801 ccgtgacgac aaccggatcg cgccactaga tggggtgggc gcattgctgc gttatgccgc
2956861 caccaaccga ctcggcagcc atagatccta ggatgctgca ccgcgacgat cacatcaatc
2956921 cgccgcggcc ccgcgggttg gatgttcctt gcgcccgcct acgagcgaca aatcccctgc
2956981 gcgccttggc gcgttgcgtt caggcgggca agccgggcac cagttcaggg catcggtccg
2957041 tgccgcatac ggcggacttg cgaatcgaag cctgggcacc gacccgtgac ggctgtatcc
2957101 ggcaggcggt gctgggtacc gtcgagagct tcctcgacct ggaatccgcg cacgcggtcc
2957161 atacccggct gcgccggctg accgcggatc gcgacgacga tctactggtc gcggtgctcg
2957221 aggaggtcat ttatttgctg gacaccgtcg gtgaaacgcc tgtcgatctc aggctgcgcg
2957281 acgttgacgg gggtgtcgac gtcacattcg caacgaccga tgcgagtacg ctagttcagg
2957341 tgggtgccgt gccgaaggcg gtgtcactca acgaacttcg gttctcgcag ggtcgccacg
2957401 gctggcgatg tgcggtaacg ctcgatgtgt gaattgagac ctgattcatg aaaatcgtcg
2957461 aggagacccc ataccggttc cggatcgaac aagagggcgc gatgcgggtg cccgggatcg
2957521 tgttcgcgtc caggtcgttg ctgcctcgtg acgaaggcga catggccctt gatgcaagtg
2957581 gtcaacgtgg ctacgctgcc ggggattgtc cgggcctcgt atgcgatgcc cgatgtgcac
2957641 tggggatatg gtttcccaat cggcggcgtg gccgcaaccg acgtcgacaa tgatggagtc
2957701 gtttccccag gcggtgtcgg cttcgatatt tcgtgcggcg taagactctt ggtcggcgaa
2957761 gggctggacc gcgaggagct gcaaccacgg ttgccggcgg tcatggaccg gcttgatcgc
2957821 gcgataccgc gcggagtggg cacggcgggt gtgtggcgac tacccgaccg gaacacgctg
2957881 caggaggtgc tcaccggtgg tgcccggttt gcggtggaac aggggcatgg cgtcgcgcta
2957941 gacctcgagc ggtgcgaaga cggcggtgtg atgacaggag cggacgcggc caaaatcagt
2958001 gaccgggccc tccaacgcgg gcttgggcag atcggcagcc ttggctcggg caaccacttc
2958061 ctggaagtcc aggccgtgga ccgcgtctac gatccggttg cggccgcgcc gatgggtctg
2958121 gcggaaggga ccgtctgcgt gatgatccac accggctcac ggggcctggg ccatcagatc
2958181 tgcacggatc acgtccgcca gatggaacaa gccatgggcc gatacggaat cgcggtgccc
2958241 gatcgccaat tggcttgtgt gccggtgcac tcccccgatg ggcaggccta tctcgccgcg
2958301 atggcggcgg cggccaacta cggacgcgcc aaccgccaac tgctgaccga ggcgacgcgt
2958361 cgtgtgttcg ctgatgcaac cggaacacct ctggacctgc tctacgacgt gtcgcacaac
2958421 ctggccaaga tcgagacgca tccgatcgac ggtcagctgc gctcggtgtg cgtgcaccgc
2958481 aagggcgcca cccgctcgct gccgccgcac catcacgagc tgccggccga actggcagcg
2958541 gtcggccaac ccgtgctgat acccgggacg atgggtacgg cgtcatatgt gcttgccggg
2958601 gtcaccggca acccggcgtt cttttccacc gcgcatggtg ctgggcgggt actgagccgt
2958661 caccaggccg cccgccacac cagcggtgaa gcgatacgcg ccagcctcgc aaaacgtggc
2958721 atcatcgtcc gcggtacctc tcgtaggggt atcgccgagg aaaagccgga ggcctacaaa
2958781 gacgtcgacg aggtcatcga agccagccat cagagtggcc tcgcgcgcaa agtggctcgc
2958841 cttgttccct tgggctgtgt caaaggatga atcaacggcg aacattccag ccgtcgcgac
2958901 cgccttcttc agtggtgcag acccgtgacc ggctgatggg tactggcttc gatatccgac
2958961 gacgtcaaag cgaatagctg attcgccaaa tccgacaagg cccgggcgat cgcaagttcg
2959021 tcgccgatct gggccaccgg ctcatcggcc ggatcgagtc gcgccaaacc aacacccacc
2959081 atctgcctgc ctgcccagga cagccgcgcc ttcgcccggg tgcgctcgtc gtgttcctca
2959141 atcagcacat caatttggca ggtttttcca acgtgctcgc tgtctgtcat cgcggcctcc
2959201 ctgtcggatt tgcgcttacg cccgccgatc tgccccgcta gctgaacgcg gtatctatcc
2959261 aatcaccaca atcggtcgtg gagtaggcca gaattctttt cgcccgaccc gggcccgcct
2959321 agcactgaca accgctagat ggccttcagg aggtctgctt tgcccttggt acggagtgtg
2959381 tacagaggtg agccgcgcaa ctgctcaatg cgagccgcca tcttgtcacc gagctcctcg
2959441 agctcggcat cggtgatgtg caccggtgta ggagcgggga tcatgtcgcg ttcctctacg
2959501 tcggcgtgcg cctccaacac ggtccggaac acgttccact cttcttcata cccgggcgcg
2959561 cgctgcggag tgcgcagcag cgtcgcgagc tgatcaacca cctgacggtg ctcggcgtgg
2959621 gtacccgtga ttggtttgcc ggccgcggaa agggcagggt agtacaggtc atcctcgatg
2959681 cggaagtgaa tgtccagctc gatgagcatc tcgtcgaaaa ggacatggcg ctcttcgcta
2959741 ttcaccggcg cctcgccgac tttgcggccc agtcctttaa gcacggtgtg gtggcgcttt
2959801 aatacgtcgt aggcattcac ttcgttgctc tattccgtat tcgggatcaa cgagacaacc
2959861 gtaacctcgc gccgcggccc attaatgtga ggtagctgtg aatcagcaca aagaagcctg
2959921 tgcagtagcg cgacgctcgg cgtaccggca cgagtccgac ggcccgcatg tccatgcggc
2959981 cgccggcacc agcgccgagg cccccgcagg ataccgggat ctgcagctcc tcgtgcggaa
2960041 acagttgccg cagttcgggt tcgggcagtt cggcgagcgt gatgttcgcg cctaacggca
2960101 acaactatcc gtcggcgccc tgggtgccgg gcgggcccat attgccctgg atgccggagc
2960161 tgccacccgg tgacccaccc gcgccgccgg cgcccccgtt gccgcccagc gcgaaatcgc
2960221 cgccctgacc gccggtcgcg ccggtcccgc cgttgccgcc gttgccgccc tggccgccga
2960281 ggccaccttg cccacccgtg ccgcctgcgc cggtgccgcc ggcagctcct gcccacccga
2960341 tcagcccgcc ggctccgccg ctgccgccgg tggtcccgcc ggcgccgccg gtaccgccag
2960401 tgccaccagc gccccccacg ccgcctgtac cgccgccacc gccaattgtc gctcccccgc
2960461 cggtggtggt acccgcgccg ccggcgccac cgttgccgcc ggcaccaccg atgccgccga
2960521 tgccaccggt gccgccgaca ccgccggcac ccccgccacc accaagcccg atgagcgacc
2960581 cagccgcccc gccgttgccg ccgacaccgc cgctgccacc cataccgccg gtaccgccga
2960641 caccgccgag gccccccaga ccgccggtgc cgccttccgc ggtacccgca ccgtcggtga
2960701 gaccctctcc gcccgcgccg ccgacaccgc ccgcgaagcc ggcggcgcca ccaccaccgg
2960761 tgccgcccgt cccgccggcc ccaccggcgc cgccgttgcc gattaacatc ccgccacgtc
2960821 caccgtttcc accggcacca ccggtgccgc cgttaccgcc cgccgcgcct agtgccccgt
2960881 taccgtcacc gccgattccg ccgtcaccgc cgaaagcgtc acctacaccc gtgttgtgcc
2960941 cctgcccccc cttgccgcca gcaccaccca cgccaccgtc gacccctccg gtggcaccgt
2961001 cacccccctc acccccggta gccacgccgc cggcgctgcc gtcggtctca cctatgccgc
2961061 cagcgccgcc agcgccgccg gcaccgccat cggtaccggc agtacccccg gctccaccct
2961121 taccgccggt gccgtcgttg ccgtcgagcg actcccccag cccgccctgc ccgccgacgc
2961181 cgccagcctc gccgacgcca ccggcggggc cgggaccccc gttcccgcca gtttgattcc
2961241 cgttgccgct gttgtcggta ccgttcgcac cggtgttggg gttcgcaatc gagccggggt
2961301 tgaccccgtt tgtcccggcc agaccggtgc caccctgccc gccggcacca ccggacccga
2961361 accagttggc attaccgccg ttgccgcccg cgccgggcat cccgcccagg acacccgcca
2961421 cggccggccc accctgtccg ccggcaccgc catcgcccaa caacatcccg ccggcaccgc
2961481 cattaccacc ggccgccccg gccccaccca gacccccaac accgccattg ccgatcaata
2961541 gcggacccgc accgccgtca ccaccgggcg caccgtcccc accaacgccg ccaccgcccc
2961601 cggtcccgaa gtagctggcc gcccctccga cgccgccggc ggcgccaagg ccaccggccc
2961661 cgccgaatcc accattgccg aacacgccgc caacgccacc gctcccgccc acgccgccgg
2961721 tggtgcccac ccccgccgcg gccccgccag caccgccgaa gcccccgctg ccgatcaacc
2961781 ccgtcgcccc accgacaccg ccagtaccgc cgaccaaagt ggcccctgca gccccaccag
2961841 ccccaccggt cccgccatta cccagcaacc atccaccgcg accaccgaca cccccggcag
2961901 caccggaccc gaccagcccg tccccacctt taccgccagt cccgccgtta ccgatcaacc
2961961 ccgcatcccc gccagcacca cctggctgac ccggcgcacc cgatccgcca ttcccgccgt
2962021 tgccaagcaa cagcccgccc ggcccaccgg gagcccccgt cccgtcggcc ccgttagcgc
2962081 cattgccgat caacgggcgc cccaacaacg cctgggcggg ggcatttacc acgcccaaca
2962141 aatcctgcaa cggcgcagca ctggtggcct cggcaactac gtatgagcgc gcgccgttcg
2962201 taagggactg cacgaactgg gcgtgaaacg ccgacagctg cgcaccaaaa gcctgatagc
2962261 tctgcgcgta cgacccgaac aaggccgcaa ctgccgccga aacctcatcc gcggcagccg
2962321 ccaccacccc cgtggtcggc aatgccgccg ccgcattcgc cgcgttgatc gtcgacccaa
2962381 tgttggccag atccgaagcc gccatcgtca atgcttccgg caccgcaatc acaaatgaca
2962441 tctgcgacct cctggaccgg acaacccgca tggtcgccgc ggatcatcga gcactcggca
2962501 gcaacaaatc ctatcccgcc tcgcagacgg cggaggccat ttggccgccg gcgcgtactc
2962561 ttcgctacga ccgccagagc ccttggttag cgaccggatt cgaccgccgc atgagccaaa
2962621 ctgttaccgg tgtgggtgtg cagaactgcg cagttagcaa acgccgatgc agcgcggtgg
2962681 accacagcag ccgcacaccg taccggcgct gagtgataaa cccgacccgg gcccggcgga
2962741 tgcgatatcg tcttgcggct atggcgggta tgccagaggg caaactcatc ctcctcaacg
2962801 gcggatccag cgcgggaaag acgtcgctcg ccttggcgtt tcaggatctt gccgccgagt
2962861 gttggatgca cattgggata gatctgttct ggtttgcgct gccgccagag cagcttgacc
2962921 ttgcgcgggt gcggcccgag tactacacat gggacagcgc ggtcgaggcc gacgggctgg
2962981 agtggttcac cgtgcacccg ggccccatct tggacctggc catgcattcc cgctaccgcg
2963041 ccatcagggc atacctggac aacggaatga acgtcatcgc cgacgacgtg atctggacac
2963101 gtgagtggct ggtagacgct ctgcgggttt ttgagggctg ccgagtctgg atggtcgggg
2963161 tccacgtatc cgacgaggag ggtgcccgcc gggaattaga acgcggcgat cgccaccccg
2963221 ggtggaaccg aggcagtgcg cgcgctgccc acgccgacgc cgagtacgac ttcgagctgg
2963281 ataccaccgc gaccccggtc cacgagctgg ccagggagct gcatgagagc tatcaagcct
2963341 gcccgtaccc catggctttc aaccggttac gcaaacgctt cctatcttga aatggagcca
2963401 aaagtcgtgc gcaactggaa ctttcactcc tggcaaacgc tggggcgacc cgtcaccgcg
2963461 cgcttgggtt cgggtcgaat cgtcggccgc gcgggtcgtg cggaacattg cacccgacgc
2963521 ggcggaatcg gagttgagaa gtacatggcg ggacgcaccc ggcaccggtc aggcattctt
2963581 tacccatgga tgtggaggcc ctgctgcagt cgatcccgcc gctcatggtc tacctggtgg
2963641 tcggcgcggt ggtagggatc gagagcctgg gcatccccct tcccggcgag atcgtgctgg
2963701 tcagtgccgc ggtgttgtcg tcgcaccccg agctggccgt caacccgatc ggcgtcggcg
2963761 gcgctgcggt gatcggcgcc gtggtcggcg attcgatcgg ctactcgatc ggccgccgct
2963821 tcggcttacc gctattcgac cggctgggcc ggaggttccc aaaacacttc ggccccggtc
2963881 atgtcgcgct tgctgaacgg ttgttcaacc gatggggagt ccgagccgtg ttcctcggtc
2963941 gcttcatcgc gctgctgcgg atattcgccg gaccgctcgc tggcgccctg aagatgccct
2964001 acccgcgctt cctggccgcc aacgtcacag gcggcatctg ctgggccggc ggcaccactg
2964061 cactggtcta cttcgccggg atggccgccc agcactggtt ggaacggttc tcctggatcg
2964121 cgctggtcat cgcggtcatc gccggcatta cggccgcgat cttgctgcgc gaacgcactt
2964181 cgcgcgcgat cgccgaactc gaggccgagc actgccgcaa agccggtacc accgcggcgt
2964241 gaccgaccgg cttgaatccg gtacccacgc tcacaggagc tgcaatctag acagatctcc
2964301 agtcatgtca taaaaatgag atctgaaatt acttgacaag cttgtcttcg gacagtgcgg
2964361 ggcatccgcc gcggtggctg tacgccgtcg attaggagcg caccatgggc ctgatcacta
2964421 cagaaccacg ctctagtccc cacccgctca gcccacggct cgtccacgag ctaggcgacc
2964481 cacacagcac gctgcgggca accactgacg gcagcggggc agcgttgttg atccacgcgg
2964541 gcggcgagat cgatggccgc aacgagcatc tctggcgtca attggtcacc gaggccgccg
2964601 ccggcgtcac ggcgcccgga ccgctcatcg tcgacgtcac cgggctcgat ttcatgggct
2964661 gctgcgcttt cgccgcactg gccgacgagg cacaacgatg tcggtgccgc ggcatcgacc
2964721 tgcgtctggt gagccaccag ccgatcgtcg cccggatcgc cgaagcgggt gggctgagcc
2964781 gagtgctgcc catctacccg accgtcgata ctgcgctcgg caagggcacg gccggtccag
2964841 cccgttgctg atcccggccg taagagcacc gagccgaccg ccggtggccc caccgctagg
2964901 gccgatcgca ccgccgcgcg acgatgttcg cgtcaggcgc gcatgcggta tcgcttgcct
2964961 tgcaaggtaa tccacttcgg acatccacga tgcaggtcgc gatcaagtcg ggcgcgccgc
2965021 agcagtcagt ggccgcgagg ggcgtacatg atcacggcta ccccggccat gcagccaagg
2965081 gcaccgatga catcccaccg gtcgggccgg aacccgtcca gggccatgcc ccaggcgagc
2965141 gaaccggcga caaacacacc accgtaggcg gccaagaccc gaccgaaatg ggcgtccggc
2965201 tgcaatgtgg cgaagaaccc atagacccca agcgcaataa ctccgagtcc cgcccaaagc
2965261 caaccccgtt gctcgcggac gccctgccat accagccacg cgccaccgat ctccgcaacc
2965321 gccgccagga cgaatagcag gattgaccgc accaccatgg ttgcgagcct acgagatccg
2965381 ctgccctgcc gccccccaac caatcgcgca ccccaaatgc ttcccgtcac ccgcgctcag
2965441 ccagacaccg gtgttggcta caactatggt tcccggatca ggcgcagcag ttcgggttga
2965501 gcacggtaca cagcgcttgc agggcttcag gatgtacccg atggaagacg tgcatgcccc
2965561 ggcgatcgga aatgaccagg ccggccttgc gcagctgggc caagtggtgg ctgacggtgc
2965621 catcgctgag gctgagcgcc gccgctagtt ggccgctgac ctgctcgccg gccggcgagc
2965681 tgaacaggta ggacatgatc ttgactcgtg ccgggtcggc cagggccttc agccgcagcg
2965741 ccaccgccaa ggcgtcgccg tcgctcatcg gccccgccgc caccggggcg cagcacacgg
2965801 gagcggagat gtcaatcacc ggcagcgact tgggcatagg cccaccctgc cagatacctt
2965861 gacatatatc aaagagatgt tgcacactgg gttcggcgcc attttgatat aagtcaaaca
2965921 actgggaggt gtctaccaat gtcccgcgtt cagctagccc tcaacgtcga cgacctggag
2965981 gccgcaatca cgttctactc caggctgttc aacgccgagc ccgccaaacg caagcccgga
2966041 tacgccaact tcgcgatcgc cgatccgccg cttaagttgg tgctgctgga gaaccccggc
2966101 accggcggta ccctcaacca tctcggtgtg gaagtcggct cgagcaacac cgtgcatgcc
2966161 gaaatcgccc ggttgaccga agccggactg gtcaccgaga aggagatcgg caccacgtgt
2966221 tgctttgcca cccaggacaa ggtgtgggtg accggcccgg gtggggaacg ctgggaggtt
2966281 tataccgtgc tggccgactc cgagaccttc ggcagcggtc ctcggcacaa cgacaccagc
2966341 gacggcgaag caagcatgtg ctgcgacggc caagtcgccg ttggcgcaag cggctaactg
2966401 taggcctgac cccggggtgc gtctccaagc cgcggagccc accccgggcc actcaatgcc
2966461 ccctaacccg cgtagcgccg ttcaccgcgt ggccgcttgc ggacctgatt cgatatttgt
2966521 caatattgat gtatgtcgaa tctgcatccg ttaccagagg tggcgagctg cgtagtcgcg
2966581 ccgctggtgc gcgaaccgct gaatcctccg gccgcggccg aaatggcggc ccggttcaaa
2966641 gccctggccg atccggtgcg attgcagctg ctgagctcgg ttgccagtcg cgccggcggc
2966701 gaggcctgcg tctgcgacat ttccgcggga gtcgaggtga gccagcccac gatttcgcat
2966761 catctcaagg tgctgcgcga cgcgggtttg ctgacctcgc ggcgtcgggc ctcgtgggtg
2966821 tactacgccg tggtccccga ggcgctgacc gtgttgtcga acctgctcag cgtgcatgcc
2966881 gatgccgcac ccgccctggg ggcaccggca tgacggagac ggtcacccgc accgccgccc
2966941 cggcggtggt gggcaaactc tcgacgctgg accgcttctt gccggtgtgg atcgggtcgg
2967001 caatggccgc cgggctacta ctgggccggt ggattcccgg cctgcacacc gccctagaag
2967061 gggttcagct cgacgggatt tcgctgccga tcgcgctagg cctgctgatc atgatgtatc
2967121 cggtgctggc caaggtgcgc tacgaccgcc tcgacaccgt caccggtgac cgcaagctgc
2967181 tactcagctc gctgctgctg aactgggtac tgggcccggc gttgatgttc gcgctggctt
2967241 ggctgctact ggcggatctg cccgagtacc gcaccgggct gatcatcgtg ggcctggctc
2967301 gctgcatcgc catggtgatc atctggaacg acctggcctg cggggatcgc gaagccgccg
2967361 ccgtgctcgt cgcgttgaac tcgatctttc aggtggccat gttcgccgcg ctcggctggt
2967421 tctacctgtc ggtgctaccg ggttggctgg gcctcgagca gaccaccatc gccacatccc
2967481 cgtggcagat cgccaagtcg gtgctgatct tcctcggcat cccgctgctg gccggctacc
2967541 tgtcgcggcg gatcggcgaa aagaccaagg gccgcaactg gtatgaatcc cgcttcctgc
2967601 ccaaggtggg accgtgggcg ctctacggtt tgctgttcac catcgtgatt ctctttgcgc
2967661 tgcaaggaga tcagatcacc ggccgaccgc tggacgtcgc acgcattgcg ctgccgctgc
2967721 tggcctactt cgccatcatg tgggtaggcg gctacctact gggggcggcg ctgcggctag
2967781 ggtatcggcg caccaccacg ctggcgttca ccgccgcgag caacaacttc gagctggcca
2967841 tcgcggtggc catcgccacc tacggcgcca cctccgggca agccctggcc ggagtcgtcg
2967901 ggcccctgat cgaggtaccc gtcctggtgg ggttggtcta tgtgtccctg gcgctgcgca
2967961 accgcctcgc cggtcccaac gcgacccacg atgccgacaa acccagcgtc ctattcgtct
2968021 gtgtgcacaa cgccggacgt tcccagatgg ccgccgggct attgacccac ttggccggtg
2968081 accgcatcga agtccgttcg gccggaaccg agcccgccgg tcaggtcaat ccgacggctg
2968141 tggccgcgat ggccgaaatg ggcatcgata tcaccgccaa tgcccccaca ttgctcaccg
2968201 gcgggcaggt ccagtccagc gacgtcgtca tcacgatggg ctgcggcgat gcctgccctt
2968261 acttcccggg tgtctcctac cgcaactgga aactacccga tcccgccggc cagcccctcg
2968321 acgttgtgcg catgatccgc gacgacatcg cagaccgcgt ccaagccctg atcgccgagc
2968381 tgctggccac cgccaagacc agatagcgtg tgccacgctc ggtgctgcgc cgatacgtga
2968441 ggtcccggct gggatcggat tttccgcgtg tacggcggct aggcaccagc ggatcgcatt
2968501 tgtactggtt agagacttgc cgagtggccg cattagcctg cgtggagcgc ttggtcaaaa
2968561 agctcggccc tgttcggccc tatgggttcc tgttgatctg ccctgttcgt agtctcgaca
2968621 aagcggctgc ccgagatcgc gtgcgacgat atcgggagcg gctgcggcaa cgaggtctgc
2968681 ggccgataca gatctgggtt cccgatgtga acgcacccga atttgtcggc gaagcacacc
2968741 gtccgtcggc gctcgtcgcg gcccgcgaat acgaggacga cgatcaagcc ttcgtcgatg
2968801 cggtatcggt cgactgggac gacgccacct gacgtgcggc gcggcgacat ccacaccgcg
2968861 gcggcgcgtg gtgcctacac cggcaagcca cgccggtcgc ggtcatccag aatgaccggt
2968921 tcgattcgac ggcctcggtt accgtcgtgc cgtttaccac gcgtgatgtc caggcatccc
2968981 tgatgcgaat cccggcccca gcgtccaaca ccaccgggct gaccgagacc agtcgcctga
2969041 cggtcgacaa ggtgacaaca tcccccgcac cagcctgacg cggcaggttg gtcggttatc
2969101 ggccaaaaac atggtcaggc tcgaccgtgc attgctggtt ttcctggccg gctgacaatt
2969161 gcgccacctg gtcatcagaa ctgatcgggc ggggaaacga aacggggctc ccagcggagg
2969221 tcatgagttg gcgcgccggt ttcgccgcga tctctccgaa cttgaccgct aaacctcggg
2969281 gcagaagtca tgaacaagcc cgttaggagg cgtttgaggc cgtaaatgtt gatgagggcg
2969341 gggaaagtgt cgtcatggcc gtcgcgctga attcaccacg cccccacgac ggagctcgtg
2969401 ggcacccagc attcactgct taccactacg atctcgctca cgaggttcga gcagccactg
2969461 tcgcctgccg ccaacgaata atgctccctg acctagtggt cccggctggg atcgaaccag
2969521 cgaccttccg cgtgtgaagc ggacgctctc ccactgagcc acgggaccgg cgccgaggag
2969581 atgaacgagg tcgaagatta gcacgtgcaa gacatcgtca gcagcagtct acgtgcgctt
2969641 cacatagggg ctgcgatagc ctagagccgc aacgtaccaa gagatttgtg tgggcccgct
2969701 cacctcgact atcgtcgtgc ttcgcaccgg gcgacgatct cgttcgttgc gcgcggatgt
2969761 agcgcagttg gtagcgcatc accttgccaa ggtgagggtc gcgggttcga atcccgtcat
2969821 ccgctcgaag gtgctagtgg catcaaatcc cagcggtgga gtggccgagt ggtgaggcaa
2969881 cggcctgcaa agccgtgcac acgggttcga ttcccgtctc cacctccagg ttcaaccccc
2969941 agcgcgatta gctcagcggg agagcgcttc cctgacacgg aagaggtcac tggttcaatc
2970001 ccagtatcgc gcaccagtgt tcgagcaggt caggcctggt ttttaccggg ccttcgccgt
2970061 ttccgcgcaa taaacgcgca atagtgccgc cgctgggtgc gccccacgga ggagtttgct
2970121 aaatgaccac cacgccccga caacccctgt tctgcgccca cgccgacacc aacggcgacc
2970181 cgggccgctg cgcctgcggc cagcagctcg ccgacgtcgg cccggccacc ccgccaccgc
2970241 cctggtgcga accgggcacc gaacccatct gggagcagct caccgaacga tacggcggcg
2970301 tcacaatctg ccagtggaca cgatattttc cggccggcga cccggtggct gccgacgtgt
2970361 ggatcgccgc cgacgatcgt gtcgttgacg gccgggtgct gcgcacccaa ccggcgattc
2970421 actacacgga accgcccgtg ttggggatcg gcccggcggc ggcccgccgg ctggccgctg
2970481 agctgctcaa cgccgccgac accctcgacg acggccgccg gcagctagac gacctcggcg
2970541 aacaccggcg gtgaacaccg cgacccgggt ccggctggcc cgcaaacgcg ccgaccggct
2970601 caatctgaaa ctaatcaaga acggccacca cttcaggttg cgtgacgccg acgagatcac
2970661 gctggcggtc gggcacctag gggtggtgga agccttcctg gcggcggcca agtcgcaaaa
2970721 caagccgccc ggtccgccgc cgagcctcca cgccccgcca tcctggcggc gcgacatcga
2970781 cgactacctg ctcaacctga acgccgccgg tcaacgccca gcgacgatcc ggctacgcaa
2970841 gacggtgctg tgcgcagccg cccacggcct cggccgccca cccgccgacg tcaccgccga
2970901 acacctcctg gactggctag gcaaacagca gcacctctcc ccagagggcc gcaaaaccta
2970961 tcgcagcacg ttgcggggct tcttcgtgtg ggcctacgaa atggaccggg tgcgcgacta
2971021 tgtcgcagac tccctgccta aggtgcgctg cccgaaacag ccgccccgcc cggccggcga
2971081 cgacgtctgg caagcggcgc tggccaaggc cgaccgtcga atcgagctga tgatccgcct
2971141 agccggtgag gccgggctgc gacgcgccga agccgcccag gcgcacaccg gcgacttgat
2971201 ggacggcggg cttctcctcg ttcacggcaa aggtggtaaa cgccgtattg tgccgatcag
2971261 cgactacttg gccgcgctca tccgcgacac cccgcacggc tacctgttcc ccaacggcac
2971321 cggcggccac ctcaccgccg aacacgtggg aaaactcgtc tcccgggcat tacccggtga
2971381 cgcgaccatg cacaccctgc ggcaccgata cgccacccgc gcctaccgcg gctcccacaa
2971441 cttgcgagct gtacaacaac ttctcggtca cgcctcgatc gtgacaacag aacgctacac
2971501 agcgctgtgc gacgacgagg tgcgcgccgc agcagcagcc gcatggtgag tcgccctggc
2971561 gtttgctgca gccgatcggc gtcacccccg acaggcggct cgtattcggc cagcggcggc
2971621 tcgaggctgc acggctgctc ggatgggagc gcatcccggt gcacgtgtgc cacacgatcg
2971681 ccgacgtggt cgaccgggcc aaagccgaac gctccgaaaa cacgcttcgc aaggatttca
2971741 ccccctcgga gctgctcgcc gctggtcgcc ggatcgccga gctggaacgg ccgaaagcca
2971801 aacagcggca acgcgaaggc ggcgaccatg gccgccaggc tcgatattct ggcttaggct
2971861 ccatggagcc taagccagaa tcagagcgcg atgcccacaa agccgacact gccatcagcg
2971921 aagccctcgg catctcccgc ggccactacc agcggctcaa acgaatcgac aacgcaaccc
2971981 gcagcgaagc tggctaccgg gatggtttaa acggttggag cggctgaccg ccggtgcccg
2972041 ggatgggccc cggcggcaac ttgtccaacg ggcgacgctc acgtccacgc ttgcgcagct
2972101 catcttcgtg aaccgccccg gcatgtccgg agactccagt tcttggaaag gatggggtca
2972161 tgtcaggtgg ttcatcgagg aggtacccgc cggagctgcg tgagcgggcg gtgcggatgg
2972221 tcgcagagat ccgcggtcag cacgattcgg agtgggcagc gatcagtgag gtcgcccgtc
2972281 tacttggtgt tggctgcgcg gagacggtgc gtaagtgggt gcgccaggcg caggtcgatg
2972341 ccggcgcacg gcccgggacc acgaccgaag aatccgctga gctgaagcgc ttgcggcggg
2972401 acaacgccga attgcgaagg gcgaacgcga ttttaaagac cgcgtcggct ttcttcgcgg
2972461 ccgagctcga ccggccagca cgctaattac ccggttcatc gccgatcatc agggccaccg
2972521 cgagggcccc gatggtttgc ggtggggtgt cgagtcgatc tgcacacagc tgaccgagct
2972581 gggtgtgccg atcgccccat cgacctacta cgaccacatc aaccgggagc ccagccgccg
2972641 cgagctgcgc gatggcgaac tcaaggagca catcagccgc gtccacgccg ccaactacgg
2972701 tgtttacggt gcccgcaaag tgtggctaac cctgaaccgt gagggcatcg aggtggccag
2972761 atgcaccgtc gaacggctga tgaccaaact cggcctgtcc gggaccaccc gcggcaaagc
2972821 ccgcaggacc acgatcgctg atccggccac agcccgtccc gccgatctcg tccagcgccg
2972881 cttcggacca ccagcaccta accggctgtg ggtagcagac ctcacctatg tgtcgacctg
2972941 ggcagggttc gcctacgtgg cctttgtcac cgacgcctac gctcgcagga tcctgggctg
2973001 gcgggtcgct tccacgatgg ccacctccat ggtcctcgac gcgatcgagc aagccatctg
2973061 gacccgccaa caagaaggcg tactcgacct gaaagacgtt atccaccata cggatagggg
2973121 atctcagtac acatcgatcc ggttcagcga gcggctcgcc gaggcaggca tccaaccgtc
2973181 ggtcggagcg gtcggaagct cctatgacaa tgcactagcc gagacgatca acggcctata
2973241 caagaccgag ctgatcaaac ccggcaagcc ctggcggtcc atcgaggatg tcgagttggc
2973301 caccgcgcgc tgggtcgact ggttcaacca tcgccgcctc taccagtact gcggcgacgt
2973361 cccgccggtc gaactcgagg ctgcctacta cgctcaacgc cagagaccag ccgccggctg
2973421 aggtctcaga tcagagagtc tccggactca ccggggcggt tcatcggcgg ccttgcgtgc
2973481 ctgctcagcc tggcggcgcc aagcctcata gcgacgccga atctccctct caatcgcgcg
2973541 ctgcacaccc atccggaact gatcctggac acgctgctgc tgccgaaccc aacgctcaag
2973601 ctcacgccgg tagtcgttga ctgatctcgc cacccaaaat cacccctctt gaccctcttg
2973661 gttctctttt tggcggcgtg ggcgacccgg cacccctaag tctccgggcc gtgcgggccg
2973721 ctgggagccg aaaggttgct aaagttctcc ctttttgccc gcacgacccg aaaagggccg
2973781 cccacgcctg gcacctacgc ggtggtctgc accttcagca cgcggaacgc attgtccacc
2973841 agcacatcag aaccgactcg gaaccagcag aagaatccgc gctgtccggt cggtcggcgg
2973901 ttgccgccga acacgtgcgg caccagctcc accgtcgacc cgacccggtc ggtgatgatg
2973961 aactgcttcc agtcgccaag caccagcggg taattggtgg cggtcaccgc cgcgtccacg
2974021 gtgtccatgt tcgacacctc ccagatgtgt ttcccggcca gcatcggcgg gctggcgtgc
2974081 agcgatggga atttcagcgc cccattcgcg gtttccgcct ggcgcagcac gttgatggtg
2974141 gacaagttcg ccgcgaacgc gctgttggat tgaaagcgcg gcggcaacgc cgactgcagc
2974201 gcgtaaacgt cggcggctac aacggcttcc gtccccgcgc cggtgacggt gtagtccgcg
2974261 gtgccggtca gtgcggagac gaatccggtg ggctcgccgt tgccggagcc gctgacgaac
2974321 gccgccgcct gcagctgctc aaccgaatcc gctaggacgc ggcccacctc tgcgacgaat
2974381 ccggcggcgt caccctcaat ctcgagactg aacggaatcc agcaggagcc acggtagctc
2974441 ggcaccgccg gctgggccag cgttggcgaa tcgtcggaca cctcctgggc ttcggagtac
2974501 caatgagcct cggcgccttc ggaggtcacg ccccgccaaa cctcggaggt cgtttgcacc
2974561 accctcgcca cctgccggat cggattcgtt gaaccatcac ccgacagcag aatcgccgga
2974621 tccagcgccg ccgggatcaa aaacccgccg gcggtgtcca ccaagcccat tgctcgctgc
2974681 tcggcggcca ccgcggccgc ctcacgccac gcggccgctt cccggtcggt ccaggtcgtg
2974741 tgccccgcaa cagggttcga aaccctcttg acgaacgccc ccaggtagtc gcggttgccg
2974801 gtggccgcca gccagcgctg cgcccacgac gtcgactgcg gcggcccggt gcggcacaag
2974861 gtttccgcgg cttccgccgc ccgcgacgac atcaggccat cgcgcacaca aacgtccagt
2974921 gtgcgaaacg cgatgtcgcg caacgagttg cccggcggcg cgtcgccgtc gtcgccgccg
2974981 gtgggagcac cgggcaccac cctcagctca ccggcccggc agcggcgcag cgcctcctcg
2975041 gcttcgcggc cgcggcggcg ctgctccgcc cgcagttcct cggcgtggcg tgtcagcgcc
2975101 tgaaaacgtt gcgccacatc accggtcagg tcgccctcga cggagtcgag gagctgtttt
2975161 gccgcggaac gggtttcgtc gaggctgagc tgtttgatgt cgccatcgtc agcgaaatgt
2975221 tgttcattag tcatgagaga gttaccaatc catcagggct aacctggctt cggctagcga
2975281 acgggaaacg actgcaagcg attccgcgcg cacaccggcg atctgcgcgc ccagataggc
2975341 cggaacgccg gtcaaggaga cctccaacag cgccgcctcg acccgcacga tcacatcccc
2975401 ttcccggcgg tcccggatcg gccggaaacc caccgaaaac gcgtccacca caccagcttt
2975461 cacattcgcc agggcctcgt cgccgtccgg ggtgttcgca agctcgaacg ccccgaacaa
2975521 gccgtgaggc tcctcacgca gctcgacggc ccggccaacc gggtagcggg ttcgagcgtc
2975581 gtgggagacc agcagcttca ccttgtggcc gcgctcagcg atggagcgcc gaaaagcgcc
2975641 aggagcgaac atttcccgga actcgccgtc gaggtcgcgg acggtggtca cctcgccata
2975701 aggcacgatg acgccgtaca cggtgcggcc ctcaccaggc cgcagctcgg ccgtgcggaa
2975761 aaggatgcta ctcaaaattc ggccaccgcc tagcagacgc aagaaacgcg cggaatcgct
2975821 tgtggcgcat ggcggccgct atccgggttc cagccgcccc gcggcgactg cccggcgtcg
2975881 gcggatgccg agatgccaaa ctcgattgta tcacacacaa aaggtcatca ccggtctggg
2975941 gcgaacgggt tgaactcgtc gtcgtcgggg tcccccgccg ccgccagcac agcagccaaa
2976001 ttcgcctcag cgcttggcgt gcaccccaat tcgcgcgcga gcaccaaaac gtccctcgtc
2976061 gcggcccggg ccgcggccac ggcaggatgc accgtcaccc gtcggctgcg ggcgttcgtc
2976121 gcgatgaaac cctgttcacg gtaggctgtt acagcctgca tgagctgatc ccaggcgacg
2976181 cagaaggagg tcagcacccc aaggtcggac tccttcagca ggtttaatgc cgcaagctcg
2976241 ggaacgacgc gcccccacat gtctttagcg cctggcggca accaatccgg gcattccggc
2976301 gcaacacgct cgaacgccgc cggtggtgta acccgccggc cgccagaatc acggcccggc
2976361 gagcggccgc cgaggagttt caactgcgcc ggcgccggcg cgggaccacg cctacccatt
2976421 ttcaacacca ccctcctctt tccgggtttc gggtcgcgaa tgccatgatg ccaaaaaacg
2976481 ccccataaaa cttgagcgcg cacacgctct cccaccgtgg cggtgtccgg tcgggcggtt
2976541 gctggcgatg gcaacccacc ccccctacct gcgggtttcg ggttttcact gtttgctgtc
2976601 gggttcgtcg gggaagtgat acggatgcca gccgagcttc atccccgcct caagccggcg
2976661 ctgctcatcg tcgagatgca tcgacaacag cgccagttcg gctgtgtcgt cgtcgatttc
2976721 gtgtgatgtc gccaccatct cggcgtacgc tcggcggata gcctcgaggt cgcgctgccg
2976781 ttgggcgcgg cgctgctcgg cggacggaac gtcggccggc caaccatgtt gccgcccaac
2976841 gcgattccga cgcggggcgt tgagccctgc ggcgatggct ggctggcgtt tagtgcgctt
2976901 gtgggtcaat gatgggctcc tttctccctg gaaaatgatg tgatcgacgg tgttccgggt
2976961 gtccgacagt cgggttctct cggcgggctc acggcggatc accccggtcg acggccgccg
2977021 ccgcggcggc cgtcgcggcg aacaaaacgg ccgcgacgcc gtgcgactcc gccacagcgc
2977081 ggaccaacgc tcgcgcaagc tcgacggccg cggtccgcca tgcgcccgcg gcgtcgccgg
2977141 ccagcgcggc ggccgaagcc tcgactggcg ggccgccgac aagctcgtcc gcggcggcca
2977201 gcaacgtccg agcagccaac gcgtggccgc tcatcgggcg ccgtcccgag cgctagccgc
2977261 cgctcgacct cggcagggcc ggcatttgcc ggcggccttg gcctcagtac tgaggagctt
2977321 gttggggcat cccggcccgg agcacagcgg cgcgtcgccg ttggggtgcc cgttgggcgc
2977381 cggcggctcg tacggcaagt cgcccgcctc cgggagatcg gttgcatcgg ttgcgccggt
2977441 tgcatcaccg ggatcgccaa ccggcggtga aaccgcggaa accgcggaaa ccgataaatc
2977501 tcgttcctcg ggggtttcgt cgtcggcaga gagataccgg gaccacgcat cctcgaactg
2977561 ggtccgcgaa taccctttgt agggtggttc gccaccactg tgctggaact tcggcccgat
2977621 gccgtatctg ccgagccggg tcgcgaggcc gcgcgcgtcg agcgggtcgc cgcggcggat
2977681 ggagccccac ggtccctcct ccatccggtt cagtccggtc aggatgtcgc tggtgcgcat
2977741 ccggtcccgg tcgctgaaga ctcgacggat atcccgcagc agcagcacgc ctatgctggg
2977801 cttggctcct cgatttgcgg ttgcatccgt ttctgcggtt gcacgggcgg ttttgggcca
2977861 gtgcccgccc gcggtgtcag caaccgcaac cagggactcc cagacgtcgg cgcgccggtc
2977921 ggtcaccccg tccggcatcg ccggccaacc gctttccagc gggttaatgg cggccgccca
2977981 gttcgccaac cggtcgtgca gcttctcggc ctcggggccg ttgacgcggg ggcgccacgg
2978041 ctccacgggt tcggttggtg ccctcctgcg catcctcacc acgatcgacc gagacatgat
2978101 ggtgtcgggc aggtcgtcga ggccggccaa ggcgaccgca cagtacgctg gcagttcctc
2978161 ggtctcaacg atcttgccgc ggatgacgca gcggcccgcg acggctccct tgcggtggcc
2978221 ggcgttgatc acgccgcgaa tttcctcgtg ttctttagct ttcgggccaa acagggtgtc
2978281 acactcgtcg tacaggacgg tcggccgccc gaccggatcg gccacccgac ggaacaggta
2978341 ggccggtgtg cagttgatgg catgcaccgg ccggggcact agcggttccg tgacttcgag
2978401 tgcgcggctc ttgccagagc cgggttccgg tgacaaaaaa gcgattcggg gcgttgagtc
2978461 ccacgcctcc ataaaccagc aatgcgcaat ccagagggtg tgcgcgatca gttcatggtc
2978521 gcttggatag actacgaacc gccgcaagaa tgccctaatg tcgtcgagca attcggcgcc
2978581 gaccggcggc atcggctggc cgtcctcgtc acaccagatc gggtcgggat agtcacggcc
2978641 gtaggggatg tcagccatct cagaccacca cccgccgaat gtaggcgtca cgccgacgct
2978701 ggatctcccg agagaccgcc ggccagtcgg cggcggcgga tacgtcacgt gatgcctcgg
2978761 ccgacgcggc ctggcacgtc tccacccgga gtgcccaatg ccgagcagcg tcgcagatcg
2978821 cggcccattt gaccgggtcg gtgtcgtcga ggtcgcacca cgccggggtg ccggccatcg
2978881 gccattccac ggcggcggcc agggtcggtg cgacatactc gtgcaccgac caccacgaca
2978941 cggcgcggga cgcggtagga tcggtgctag acggtgtggc gactgtcgcg ggtgcccggt
2979001 cctctgtggc cgggcatcgt cgcgtcggcg gcgacccgcc gacggcggtc atgcggcacc
2979061 accgaacggg tgcatggcgc cgtcgacctc atcgcggcgc agacggacga ggcgggtgcc
2979121 ggagcggtat ccgcgtaggc ggccgtcggc gatcatctgg cggaccgtgc ggtcggtgac
2979181 cgctagatat tcggcggcct cactgatcgt gatgtaccgc cgtgacaacg ggggagcgtc
2979241 tgccatgccg ggcctttcgg tctcgtgaga gaccgtccac ccgagactcg gcgacgggaa
2979301 cgcgcacatg cgcgcaccgg aaaatttacc cgcctagctg gctcaagcgc aagcataatg
2979361 cgctgaacgg aattacgtgt cgcgcctctg ctattgatgg atcgtcagcg tcggggatgg
2979421 tcgacgttct cagctcgtga agcttcgccc cgaaaccgtc gaggatcgcc gcggcggtca
2979481 tctcggatat cggcgcatac tttcggcatg cccggcattc gagtttccac tcgatatggc
2979541 ggccccactg tgtttcggtg aagcgggtgt tcgaccgcat ctgtatgtgc ccgccggcgg
2979601 gtcgttcgtc gtcgatccag gcgatgatga gcgctcccgg ttcgtcgtcg cagttgcaca
2979661 taactacgta cttaaccgca tcggccatca tcacatctcc tggttctcgg ccagtttgct
2979721 taacagtgcg gcgatttcgc ggtcccggcc cttggcggcg tgctggtagc ggagtgcggc
2979781 gccggctgtg ctgtgtccta gccgctgcat cagttcggcc agtgtggcgc cggtggatgc
2979841 agccaacacg gcgccggagt gtcgaaggtc gtgcacccgt aagtctggtc ggccggcggc
2979901 ttttcgggcc ttgtagaaca tgcggtacag cgccgagggt gctaggtgac ggttggggtc
2979961 gttgaccgat gggaacagca gggactcccg gccggggttg acgtgtttgt gaaggtggtc
2980021 ttcgatggcg ggtatcagat gtggcgggat acttatgtcg cgcactcccg catcgctttt
2980081 cggtgtcgtc accttgaagc cttcgcccac ccgaacgaca gcccgccgca cccgcgcaac
2980141 ctcgccgtgc aggtcgatgt ctttgcggcg taattcggtc agctcgccgt agcgcatggc
2980201 cagccatgcc gccatcagca cgaacgcctg gtaggggtcg ggcatggctt tggtgatggt
2980261 ttccagctcg tcgagggtgg cgggcctgat cttgtggacg cggcgggcgg tggacgcgcc
2980321 tgagatgcgg caggggttgg agtcgatcag gtcgtcggcc aaggcggtct gcatgattgc
2980381 gcgcagcaag ctgtaggagt gtgcccgcat ggtcggtgtg cccacggcgg tggtggcgta
2980441 ccagcggcgc acggcggccg gggtgatgtc gcgtaggtcg gtgtcagcga aggtggccag
2980501 gatgtggttg tccagcagtt tgcgatagtg ggcgcgggtg cggtccttga ttccacgctg
2980561 cttcagccat ccttcggcgt actcaccgaa tggggctccg gggcggtctt cctgacccga
2980621 tgccggggac catagttgtc ggtcgatttc gcggcggcgg tcggtgagcc atgcttcggc
2980681 gtcgatcttg gcgttgaagg ttttgggggc gatgtacacg cggccgtcgg ggccggtgta
2980741 gctggcttgc cagcggccgg agttgaactg tcggatgcga ccgaatttgc gtctctgacg
2980801 cttgccggtt tgcgtcactg tcgtcccctg tcccgcgcaa taaacgcgca ataagagact
2980861 acatcagatg ccgcttgctt ccgcacgctt ccgggggtac tgttgtctat gtcgcctggt
2980921 cagaggcttt ctgtacaggt cagacagtat cccaccggcc cactagtgaa actggttcaa
2980981 tcccagtatc gcgcaccacg attgacctgc ggtttcatcc acaaaatctg ggctgcgtga
2981041 actaaatgtg aactgactcg gtgcaaccac cgaaaggttc ctctgttccg tgcccacgcc
2981101 gacaccgacg gtgaccccac cagatgcgcc tgccgcccgc tggctagcct ggcctgttgc
2981161 tgcaagcgcc tggtcgacgc ccgctatcac gctgttgtcg cgtccaccga actcaccgag
2981221 gcacgccgca cccgcgcaac cgagctgacg gagctgatca ccaccgcgct cgccttctgc
2981281 gaacggctgc aaacggtcgt tgagggtgac cggcgggctg aggtgacccg atgagcggcg
2981341 gctggctcgc cgagcacctc ggcctgtcca caaaccggct ccggcacgaa ctcgcagacc
2981401 ggctcgacgc gcactacggg ccacccgcac agaacaggga gctcgcgcgg ccgagcctgc
2981461 ggattatcaa cgagggcact gatggatgac ctgacgcggc tccggcgcga gcttctggac
2981521 cgattcgacg tgcgggactt cacagactgg cctccagcat cgctgcgagc cctcatcgcg
2981581 acctacgacc cctggatcga catgacggcc agcccgccac agcctgtatc gcccggaggg
2981641 cctcgactcc gactcgtgcg attaaccacc aacccatccg cgagagcagc ccctatcgga
2981701 aacggtgggg actcttctgt ttgcgctggt gagaaacagt gccgcccacc gtagcggcct
2981761 gcgcgtggca attgaccgac ctgacccgag tagccgccag tgggctgtaa gccattcttt
2981821 acggcagcct gttgtaaagg taacgtttac acgtggaggt gagggctagc gcccgcaagc
2981881 acggcatcaa cgacgacgcc atgctccacg cataccgcaa cgcgctgcgc tacgtcgaac
2981941 tggaatacca cggcgaagtt caactgctgg tgatcggccc cgaccaaacc gggcgccttt
2982001 tagagctggt catcccagca gacgaaccac cccggattat ccacgccaac gtactacgcc
2982061 cgaagttcta cgactacctg aggtgatgag ataagagtga agcacaagac cgacattgac
2982121 gagtggctcg acacgatcga gcccaacccg gccgacgccc acgatgccag ccacctgcgg
2982181 cgcatcatcg ccgcgaaaga agcggtccaa acagccgaat ctgagttgcg ggccgcagtg
2982241 aatgctgccc gcgccgccgg cgacacctgg gcagccatcg gcgtcgccct cggcatcacc
2982301 cgccaggccg cgttccaacg gttcgggcca cacagcacag cgagccccta aaccggcgcg
2982361 cctccgcggt ggagttgacg acgaccagac agggccgaag cggagtcaca gcgtctggcc
2982421 gacacacgtg gcgtcgtgtt tgctaggcat gggttttgtg tttgctgtcc cccacaaccc
2982481 cagacccgta caaatcccca gacccctaca cacagcgaca cggcgacccg ccgtctcctg
2982541 agtgtgtttg ctaaaatttc gtttgttctg gtcgatcact tattgtgttt gccggttttg
2982601 gcgatgggct tgattcctct gacagcaaca ccagttggcc ccttcctggc caggacgtga
2982661 tagaccacgc tggtgggtca tgcgcaccgg agcacccgat gatcgtcgtc cgtacggccg
2982721 aggcggccga gcaggccctg actgagggcc agctggtctg cccccgccgc ggatgtggcg
2982781 acaccttgcg gcggtggcga tatggacggc gccggcatgt gcgcagcctc ggctcgcagg
2982841 tgatcgatgt gcggccccag cgggtgcgtt gccgcagatg cgaaagcacc catgtgctcc
2982901 tgccagcggc gctacagcca cgcctagggc gcggcggcgg cggccagtta cgtccagggg
2982961 tgtggtgtac gggcaggtaa ggccggtggg cgtgtcgtag cccagtagtg ggcggtcatc
2983021 gcgtgatcct tcgaaacgac cagcaaaagt caatcgaagg aaatgacgca atgacctctt
2983081 ctcatcttat cgacaccgag cagcttctgg ctgaccaact cgcacaggcg agcccggatc
2983141 tgctgcgcgg gctgctctcg acgttcatcg ccgccttgat gggggctgaa gccgacgccc
2983201 tgtgcggggc gggctaccgc gaacgcagcg atgagcggtc caatcagcgc aacggctacc
2983261 gccaccgtga tttcgacacc cgtgccgcaa ccatcgacgt cgcgatcccc aagctgcgcc
2983321 agggcagcta tttcccggac tggctgctgc agcgccgcaa gcgagctgaa cgcgcactga
2983381 ccagcgtggt ggcgacctgc tacctgctgg gagtatccac tcgccggatg gagcgcctgg
2983441 tcgaaacact tggtgtgaca aagctttcca agtcgcaagt gtcgatcatg gccaaagagc
2983501 tcgacgaagc cgtagaggcg tttcggaccc gcccgctcga tgccggcccg tataccttcc
2983561 tcgccgccga cgccctggtg ctcaaggtgc gcgaggcagg ccgcgtcgtc ggggtgcaca
2983621 ccttgatcgc caccggcgtc aacgccgagg gctaccgaga gatcctgggc atccaggtca
2983681 cctccgccga ggacggggcc ggctggctgg cgttcttccg cgacctggtc gcccgcggcc
2983741 tgtccggggt cgcgctggtc accagcgacg cccacgccgg cctggtggcc gcgatcggcg
2983801 ccaccctgcc cgcagcggcc tggcagcgct gcagaaccca ctacgcagcc aatcacggtc
2983861 gacacaatgc ataacgtcaa cctactgttg acgtcatgcc ggagcccaca cccaccgcct
2983921 accccgtccg cctcgacgag ctcatcaacg ccatcaaacg ggtgcacagc gacgtgttgg
2983981 accaactcag cgacgccgtc ctggccgccg agcatctcgg cgaaatcgcc gatcacttaa
2984041 tcggccactt cgtcgatcag gcccgccgct cgggcgcctc ctggtccgat atcggcaaga
2984101 gcatgggcgt caccaaacag gccgcgcaaa agcggttcgt cccccgagcc gaagccacca
2984161 cactggattc aaaccagggc ttcaggcgtt tcacgccgcg ggcccgcaac gccgtggtcg
2984221 cggcccaaaa cgccgcgcac ggagccgcca gcagcgagat cacccccgat cacctgttgt
2984281 tgggagtgct cactgacccg gccgcactgg ccacggcgtt gcttcagcag caggagatcg
2984341 acatcgcaac cctgcgtacg gcggtcacgc tccccccggc agtcaccgag ccgcctcagc
2984401 cgatcccgtt cagcggcccg gcgcgcaagg tcctcgagct caccttccgc gaggcgcttc
2984461 ggctgggcca caactacatc gggaccgaac acctgctgct ggcactgcta gaactcgagg
2984521 acggggatgg gccgttgcat cgatccggcg tcgacaagag ccgcgccgag gccgacctga
2984581 tcaccacgct cgcatcgctc accggcgcca acgctgccgg cgcaaccgat gccggcgcaa
2984641 ccgatgccgg ctgaggcgag cgacccctcc ccttcgcggc gccgcgtgtg caatcatgcg
2984701 aaggtccccc accgggagcc gaggaggcac agatgcgcca ctggctgatc gtcctcgcta
2984761 cgctgctcgt cgccgccgcg ggcgttgcgg ccgccaacga cgtgccccgt gcgtgggccg
2984821 gcgacgcgcc gatcggccac atcggcgaca cgctgcgtgt ggacaccggc acctacgtcg
2984881 ccgacgtcac cgtcagcagc gtcgtaccgg tcgatccgcc gccgggattt ggctataccc
2984941 gcagcggcgt cccggtcaaa agcttccccg acagctcagt gacccgcgcc gacgtgacgg
2985001 tccgcgcggt ccgggtgccc aactccttca tcttggccac caatttcagc ttcaccggag
2985061 taacgccgtt tgccgacgcg tacaagccgc ggccgtgcga cgcatccgat tggctcgacg
2985121 ccgcgttggg caacgcgcca cagggctcga tcgttcgcgg cggggtgtac tgggacgcct
2985181 accgcgaccc ggtgtcggtt gtcgtgctgc tggacgagaa aaccggccag cacctcgcac
2985241 agtggaacct ttgacctgcg cctcgagatc gccacggccg acgtgaccga cgccgacgag
2985301 ttggccgccg tcgccgcacg caccttcccg ctggcgtgcc caccagcggt cgccccggag
2985361 cacatcgcgt cgttcgtcga cgccaacctg tcgtcggccc ggttcgccga gtatctgacc
2985421 gatccgcggc gcgccatcct caccgcccgc catgacggcc gaattgtcgg ttacgccatg
2985481 ctcattcgcg gtgacgaccg ggacgtggag ctgtccaagc tgtacctgct gccgggttat
2985541 catggcaccg gagccgctgc ggcattgatg cacaaggtgc tggctaccgc cgccgactgg
2985601 ggcgcgctcc gggtgtggct gggtgtcaac cagaaaaacc aacgcgcaca acgcttctac
2985661 gcgaagactg gtttcaagat caacggcacc aggacgtttc gactgggagc ccaccacgag
2985721 aatgactacg tcatggttcg cgagcttgta tgacccccgc cgtcagggcc agcaggcgag
2985781 atgtggcccg caggtacttc tttcggtatc caccggccag catttcctcg ctgaagatgg
2985841 tgtccagctt agcgccggac gccaccaccg gaatgccggc gtcatagagc cgatcaacga
2985901 gcgccaccaa ccgcagcgca acgttctggt cgtcgatgcc gtgcacgccg gtcagaaaca
2985961 ccgcggtcac accttcgatc agggtcagat atcgcgacgg atgcatggtg gccaggtgcg
2986021 cgcacagcgc gtcgaagtcg tcaagggtcg ccccctcaac acgtgcggca cgcgcggcca
2986081 cctcctcgtc ggacagcggc gccggtgccg gcggcagatc acggtgtcgg tagtccggac
2986141 cctcgatcct caccgtggtg aaaatgcttg ccagggtgtt gatctcgcgt agaaagtcct
2986201 gggcggcgaa gcggccctcg ccgagctgtt cgggcagtgt gttggaggtg gcggccaccg
2986261 aaaccccccg ctcgaccaga gccgaaagca gccgggagat cagcgtggtg ttgcccggat
2986321 cgtccagctc gaactcgtcg atacataaag cggtgtaatt ggccaacaga tcgatacagt
2986381 cggcgaagcc gaacacaccg gccagctggg tcagctcacc gaacgtcgcg aatgcctttg
2986441 gacatgtcgg cgcgtccggg ccggttccag gcagctggta gtaggcagag gccagcaggt
2986501 gcgtcttgcc taccccgaac ccaccgtcca ggtacagccc cacaccgggc aacacgtcgc
2986561 gcttgccgaa ccatttcttg cggcctgcac gccgctcgac ggcctgccgg caaaagtcct
2986621 ggcacgccac gacggcggcc gcctgggtgg gttcaaccgg gtcaggtcga tacgtcgcga
2986681 agctcacctc ggcgaacgtc ggaggcggcc gcagttgggc gatcagccgc accggagaca
2986741 cggtcggatg cctgtccacc aggtggtcca ccgaaccgca agcttcggag gcagacccgt
2986801 gcatggtggc actgtagcga cgtgctgcaa tcaaggtcat gcccgactct ggtcagctcg
2986861 gagccgctga caccccgcta aggctgctca gctcggtgca ttacctcacc gacggcgaac
2986921 tcccccagct ttacgactat ccggatgacg gcacctggtt gcgggcgaac ttcatcagca
2986981 gcttggacgg cggcgctacc gtcgatggca ccagcggggc gatggccggg cccggcgacc
2987041 gattcgtctt caacctgttg cgtgaacttg ccgacgtcat cgtggtcggc gtgggcaccg
2987101 tgcgcattga gggctactcc ggcgtccgga tgggtgtcgt ccagcgccag caccggcagg
2987161 cccgaggcca aagcgaagtt ccgcaactgg caatcgtcac caggtccggt cgccttgacc
2987221 gtgacatggc ggtattcacc cggaccgaga tggcaccgtt ggtgctcacc accacggcgg
2987281 tcgccgatga cacgcgccag cggctcgcgg gcctcgccga ggtgatcgcg tgctccggcg
2987341 acgatccggg cacggtcgat gaggcagtgc tcgtgtccca gctcgcggct cgcggtctgc
2987401 gccggatcct taccgaaggc gggccgacgt tgctcgggac attcgtcgag cgtgacgtgc
2987461 tcgacgagct gtgtctgacg atcgccccct acgtcgtcgg cggcctggcg cgccgcatag
2987521 tgacgggacc cgggcaggtg ctgacccgga tgcgctgtgc ccatgtcctc accgacgact
2987581 ccggctacct gtacacccgc tacgtcaaga cctgaaacag ctggacgtga atgcccgcct
2987641 cctcaccgac ccactacgcg gcccgcatcg tcgccgggtg aatggctact gtggtcggca
2987701 tgagtcggcc catgacgtca accgcgatgt tggtcgcgct gacctgctcg gcgacagtgc
2987761 tggccgcatg cgtcccggcg ttcggcgccg acccgcggtt cgcgacctac tcgggcgcag
2987821 gaccgcaagg cgcagccacc acgacaccac cgccggctgg cccaccaccg ctcgccgcac
2987881 ccaagaacga cttgtcgtgg cacgactgca cgtcacgggt gtactcgaat gctgggatcc
2987941 cagcagcgcc cggcgtcaag ctggaatgcg caagctatga caccgacctc gacccgctcg
2988001 tcggcgggtc cacagcggta agcatcggcg tagtgcgcgc gcgctccaac cagaccccga
2988061 gcgacgcagg acccctggtg ttcaccaccg gctccgacct accctcgtcg acgcagttgc
2988121 cggtctggct ggcacacgcg ggcatcgatg tgctccgcag ccaccccatt gtcgccgtcg
2988181 accgccgcgg catgggcatg tcgagcccaa tcgactgccg cgatcacttt gaccgcgacg
2988241 agatgcgtga tcaggcgcaa ttccaggctg gcgacgatcc ggtggccaac ctttccgaca
2988301 tctccaacac cgccaccacc gactgcaccg acgccatcgc gccaggcgag tccgcctacg
2988361 acaacaccca cgccgcctcg gatatcgagc gcttacgcaa actctgggac gtccctgccc
2988421 tcgccttcgt cggcattggc aacggcaccc aagtggcgct ggcctacgca gcatcgcgtc
2988481 ccgacaacgt cgccagactg atcctcgact ccccaatcgc gttgggggtc tctgccgaag
2988541 ccgccgccga gcaacaggtc cagggccaac aggcggcgct ggacgcattc gctgcgcaat
2988601 gtgtcgcggt gaactgcgcg ctgggctccc atccgaaagg cgcggtcagc gcgctgctgt
2988661 cggccgcccg gtccggtgat gggcccggcg gcgcgtcggt ggcggctgtc gccaacgccg
2988721 tcgccaccgc gttgggcttc cccgacagtg gccgggtcga tagcaccacg aaattggccg
2988781 acgcgctggc cgcggcccgc tccggggaca tgaacttgct gtccgccctg atcaaccgcg
2988841 ccgataccac ccgggatacg gacggtcagt tcatcagctc gtgcagcgat gcggtcaacc
2988901 gcccgacacc ggaccgggtg cgcgagctgg tggtggcttg ggggaagctc tacccgcagt
2988961 tcggcgccgt cgcggcgctc aacctggtga aatgcgtgca ctggcccagc agttcgccgc
2989021 cgcagccacc gaaagacctc aaggtcgacg tgctgttgct cggtgtgcaa aacgacccga
2989081 tcgtgggcaa cgaaggggtc gccgcgaccg ccgccacggc catcaacgcc aacgccgcca
2989141 gcaagcgggt gatgtggcaa ggtattggcc acggcgccag catctactcg tcctgcgcgg
2989201 tgccgccact cgtcgcctac ctggacactg gcaagctgcc tgacaccgac acctattgcc
2989261 ccgcctgata ttcggggcgg gcgggacgcg gtgtacggtg cgctggtgac ggcagctgac
2989321 tccatccgaa ccggcctagg cgcatccttg ttggccggat tccgtccgcg caccggcgcc
2989381 ccgagcaccg cgacgatcct gcggtcggcg ctctggccgg ccgccgtcct gtcggtgctg
2989441 caccgcagca tcgtattgac gaccaacggc aacatcaccg acgatttcaa gccggtctac
2989501 cgcgcggtgc tgaacttccg gcgcggatgg gacatctata acgagcactt cgactacgtc
2989561 gacccgcact acctgtatcc ccccggtggc accctgctga tggcgccgtt cggctacctg
2989621 cccttcgccc cgtcgcgcta tctgtttatc tcgatcaaca ccgcggccat cctggtcgcc
2989681 gcctacctgc tgctgcggat gttcaacttc acgctgacct cggtggccgc acccgccctg
2989741 attctggcca tgtttgctac cgagaccgtg accaacacgc tggtgttcac caacatcaac
2989801 ggctgcatcc tgctgttgga ggtgctcttt ctgagatggc tgttggacgg ccgagccagt
2989861 cgtcagtggt gcggcggcct ggcgatcggg ctgaccctgg ttctcaaacc cctgctcggt
2989921 ccgctgttgt tgctgccgct gctgaaccgc cagtggcggg ctctggtggc cgccgtcgtc
2989981 gttcccgtcg tcgtcaacgt ggccgcgctg ccgctggtca gtgacccgat gagcttcttc
2990041 acccgcacgc tgccctacat cttgggcacc cgggactact tcaacagctc gatcttgggc
2990101 aacggcgtct acttcgggct gcccacctgg ctgatcctgt tcctgcggat cctgttcacc
2990161 gcgatcacct tcggcgcatt gtggctgttg taccgctact accgcaccgg tgacccgctg
2990221 ttttggttca ccacctcgtc gggtgtgctg ctgctgtggt cgtggctggt gatgtcgctg
2990281 gcccagggct actactcgat gatgctgttc ccgttcctga tgaccgttgt gctgcccaac
2990341 tcggtgatcc gcaactggcc ggcgtggctg ggagtctacg gcttcatgac gttggatcgc
2990401 tggctgctgt tcaactggat gagatggggc cgcgcgctgg aatacctcaa gatcacctac
2990461 ggttggtcgt tgctgttgat cgtgacgttt accgtgctct atttccgcta tctggacgcc
2990521 aaggcggaca accggctgga cggcggtatc gatccagcct ggctgacgcc cgagcgggag
2990581 ggccagcggt gatcgcaagc gcggcgagcc gggcgcagcg ggtcaccgcc atcgggacta
2990641 gcggtgatcg caagcgcggc gagccgggcg cagcgggtca ccgccatcgg gactagcgtg
2990701 gacccatgac gcgcccaaag ctagaactgt ccgacgacga gtggcgtcag aagctcaccc
2990761 cgcaggaatt ccatgtgcta cgtcgcgccg ggaccgagcg gcccttcacc ggtgaataca
2990821 ccgacaccac aacagcgggc atctaccagt gccgggcctg tggcgccgaa ttgttccgca
2990881 gcaccgagaa attcgagtcg cattgcggct ggccgtcgtt cttcgacccg aaaagctccg
2990941 atgcggtgac cctgcgccct gaccactcgt tggggatgac gcgtaccgag gtgctgtgcg
2991001 cgaactgcga cagccacctg ggccacgtgt tcgccggcga ggggtatccc acgccaaccg
2991061 acaagcgcta ttgcatcaac tccatttcgc tgcgcctggt ccccggtagc gtgtagcgcc
2991121 gagattgacg ttttgcagac gccctctcgc actttcactg caaaacgtca gtctcggtga
2991181 aagtcagtcc acccgggtgg cgtgcacttc ccagaacggg gcatgtacgc ggccgcccac
2991241 cagccacggc ttaatcgccc ggaaccgctc cagcacgcac cgcacttgat cggccatatc
2991301 gggattgcgc gcggccatca gctctagggc ctcgacgctc aagttgacct ggtaggtggt
2991361 cgtccccagg taggtgatct cccaaccgcc gaccggaagc acctggcgaa aatcgtcctc
2991421 ggacaacgac cgcggcatgc tgaacccgtt gacgttgtgc tcgccgaatt cgaacatgta
2991481 cagccgtgca cccggcttgc tggcccggcg cagcgcccgc acatagcacc tttgcagctc
2991541 gggcgcggtg ctgaaggtgt ggtagaaggc gcaatcgacg acggtgtcga accggccgtc
2991601 cagcccgtcg agcgtggtgg cgtcgccgac ctggaagttc accgacaccc ccgccttacg
2991661 cgcgttgtcc cgagcccgct cgatggccgc gaccgacccg tcgatcccgg tggccgcata
2991721 tcccttggcg gcgtagtaga tcgcgtggtg cccgggcccg gtgcccgggt cgagcacctc
2991781 acctcggatc gcgcccaacg caaccagctg ttgaaccacc ggctggggac ccccgatgtc
2991841 ccatggcgtg gcggccggca acccgtgggc gacccgatca tcgcgataca tctcctcgaa
2991901 ccgggtggga tcggcaggat cgaactgggc cgtcatggca gcgagtgcac caactgctcc
2991961 accggcactc gcggaccggt gaaaaacggt gtctccgcgc gggtatggcg gcgcgcgtcg
2992021 gtggcgcgca gctcacgcat taggtcgacg atgcggtcca gctcgggcgc ctcgaacgcc
2992081 aggatccatt cgtagtcgcc cagcgcgaac gccggcaccg tgttggcccg gacgtccttg
2992141 tatccgcggg cggccatgcc gtgttcggcg agcatgcggc gacgttcctc gtcgggcagc
2992201 aagtaccact cgtaagaccg cacaaacgga tagacgcaga tgtaggcgcc gggctcctcg
2992261 ccggccagaa acgccgggat atgacttttg ttgaactccg ccggccggtg caggcccaca
2992321 ccgctccaca ccggcgtgca tgcccgcccc agcgtggtgg tgcgccggaa gtcggcgtag
2992381 gtggcctgca gggcctcgac acgttcggcg tgggtccaga ccatgaaatc ggcgtcggcc
2992441 cgcaggcccg cgacgtcgta gaggccgcgc accacaaccc cgcgctcttc ctgctgtttg
2992501 aaaaacgtgg acgcgtcgtc gatgatcgcg tcacgctggt caccgagcgc accgggactc
2992561 accgagaaca ctgagaacat caggtagcgc agcgtcgcat tcaacgcgtc atagtcaaga
2992621 cgggccatgg catctatcgt gccacctgcg catctaaggc ctcgatgacg ctggtgacgg
2992681 cccggcccgc cgcgccgacg caggccggca cgccgatccc gtcgaggtag ctgcccgcaa
2992741 cggccagcgt cggtggcagg ccggcgcgca gctcggcgac cacatcggca tggccgggac
2992801 cgtactgcgg catcgcctcg atccagcgcc ggacccgaac gtcgaccggg tcgacggcca
2992861 caccgaacac cgtgaccaag tcgtccgctg cccaggccag gagttggtcg tcggaggccg
2992921 tcagggccgg ttcgtcgccg aaccgaccga acgacagccg caacagcgcg acgtcgccgc
2992981 gctgacccca tttgcgcgac gacaatgtga tcgccttggc atgcggtgac tcgtcgccgg
2993041 ccaccagcac gccggaacag tgcggaaacg cggtgccgcc gggcaccgcc agcgccacca
2993101 ccgccgacga cgcgctcacg atctgccggg cggcggcatg tgtgcgcggc gcgatgccat
2993161 cgacgaggcg cgccaaccgc ggcgccggaa ccgccaggat gacggcgtcg gcctgccagc
2993221 ggccgccggt ttcgtcgcgc agcacccagc cgcgttcgag ctggaccacc ctggcccgca
2993281 cccagtgcac ccggctgcgc cggacgagcc cgtcgagcag cacctgatac ccgccgtcca
2993341 gcgcgccgaa caccggcccg ccgcttcccg gcggcagcgc ctgccggacc gcgtcggtca
2993401 cactggtcgc cccgcgatcc agggccgcgg ccacgctcgg ggcggccgcg cgcagcccga
2993461 tcgtcgccgc cgagcccgcg tataccccgc ttaacagcgg gtccaccgac cgggccacga
2993521 cttggtcgcc gaaccggtca gccaccaagt cggccaccgc gggatcgctg cccacctgcc
2993581 aggtgaacgg acgagcggct tcggcgtcga tccgcgccag ggttgcgtcg tcgaccagcc
2993641 ccgccatgga gcccgccgac gacgggatcc cgacgaccgt ctgcggcggc agcgggtgca
2993701 agcgctgctg gctgtagatg agcggccgcg cgccggtgct ggcgagttgg cggtccgaca
2993761 ggcccagctc ggccaaaagc gccggcatct cgggcctacg cagcacgaac gcctccgcgc
2993821 cgaggtccat tggctgtccg ccgatatgct cggtgcgcaa taccccgccg agcctatcgg
2993881 ccggttcgaa caaggtgatg gtcgcgtcat cgccgacagc ctgccgcagc cggtacgccg
2993941 aggtcaatcc cgaaatcccg cctcctacaa cacaatacga gcggggagtc atagcgagtg
2994001 tacgagcgag accaggtcgg ccagcaccgc gggatcgctt tctggcagca ccccgtggcc
2994061 gaggttgaag atatggccgg ccgcaccggc gtcgacggcg cggcgtccgt cgtcgacaac
2994121 ggcacgtgcg gcacgttcca ccgccggcca gcccgccagg accaccgccg gatcgaggtt
2994181 gccctgtaac gccgtgccgg gcaccacccg ggcggcggcg tcggtcagcg gggtccgcca
2994241 gtccacgccg acgacggccc ctcggcctgg ccgctccccg gctgtcacgg cctccgacat
2994301 cgcgcccagc aattcggcgg tcccaacccc gaagtgcgtc atcggcacgc catgctcgcc
2994361 cagcgcagcg aacacccggg cgctgtgcgg caacacgtac tggcggtagt cgatcggcga
2994421 gagcgccccg gcccaggagt cgaatacctg gatggcgtcc acccccgcgt cgatttggcc
2994481 gaccagaaac gcgatggtga ggtcggtcag cttggccatc agcgcgtgcc agctcgccgg
2994541 ctcggccaac atcatcgcct tgacgtgggc gtgatggcgg ctcggtccgc cctccacgag
2994601 gtaggaggcc agcgtgaacg gcgcgccggc gaaaccgatc agcggcacgt cgccaagctc
2994661 agcgaccaac aacgaagccg ccaccaatac cggttgaatc gcttgtggat caagtggttt
2994721 catggcggcg acatcggcgg cggtgcgcac cgggtccgcg atcaccggcc caacgtcggc
2994781 gacgatgtcc aaatccacgc cggccgcccg tagcggcacc acgatgtcgg agaacaggat
2994841 ggccgcgtcg acgtcgtagc ggcgtatcgg ctgcagggta atctcacagg ccacgtccgg
2994901 ttcgaaacag gccgccagca tgctgtaccg ctcgcgcagc gcccggtatt cgggcaacga
2994961 gcgcccggcc tgccgcatga accacaccgg cacccggctg ggcttgcggc cggtgacggc
2995021 ggccagatac ggcgactgcg gaaggtcgcg acgggtactc atcgaactca atgctgccac
2995081 gaccgccacc ccgcacctgc gtaacatcga cccaatgcca gttacctacg acgacttccc
2995141 cagcctgcgc tgcgaaatcc acgaccaacc tggtcacgaa ggcgtgctgg agctggtgct
2995201 ggactccccc gggctgaact cggtcgggcc gcacatgcac cgcgaccttg ccgacatctg
2995261 gccggtgatc gatcgcgacc cggccgtgcg cgtggtcttg gtccgcggtg aaggcaaggc
2995321 cttttcctcc ggcggcagtt tcgacctgat cgccgaaacc atcggcgact accagggccg
2995381 gctgcgcatc atgcgcgagg cccgcgacct ggtgctcaac ctggtcaact tcgacaagcc
2995441 ggtggtgtcg gcgattcggg gcccggccgt cggtgcgggt ctggttgtcg cgctgctcgc
2995501 cgacatttcg gtggcgggcc gcgccgcgaa gatcatcgat gggcacacca aactcggggt
2995561 cgccgcgggg gatcacgcgg cgatctgctg gcccctgctg gtcggcatgg ccaaggccaa
2995621 gtactacctg ctgacctgcg agccgctgtc cggggaggag gccgaacgca tcggtctggt
2995681 ctccatctgc gtcgacgacg acgatgtgct ccccaccgca acacgcctgg cggagcggct
2995741 cgccgctggc gcgcaaaacg ccatccgctg gaccaaacgc agcctcaatc actggtatcg
2995801 catgttcggt cccgccttcg aaacgtcgct cgggctggag ttcatcgggt tcggtggtcc
2995861 cgacgtccgg gaaggcctgg ccgcgcaccg cgaaaagcgc cccgcgcggt tcggcgccga
2995921 ccccgatccc ggcgccggca gctgagcaca gttcggcgcg cctgtgcaca cgtgtcggcg
2995981 gataggtcta ccgtcgaaat ctgtgacctc cgccggcgac gatgcagagc gcagcgatga
2996041 ggaggagcgg cgcttgacct ccgccggcga cgatgcagag cgcagcgatg aggaggagcg
2996101 gcgcttgacc tccgccggcg acgatgcaga gcgcagcgat gaggaggagc ggcgcttgac
2996161 ctccgccgag ccggccctat tccgcgaggc agtagcggcg atgaacgctg tcaccgtgcg
2996221 gccggaaatc gaactcggcc ctatccgacc gccgcagcgg ctagctccgt acagctatgc
2996281 gctgggagcc gagatcaagc atcccgaact cgacgtcatt ccggagcgtt ccgagggcga
2996341 cgccttcggc cggctgatca tgctgtatga cccggacggc tccgatgcat gggacggcac
2996401 tattcgcctg gtcgcctatg tccaggccga cctggactcg agtgaagccg tcgaccccct
2996461 gctgcccgag gtggcatgga gttggctggt ggacgcgctg acagcgcgca ccgaccaggt
2996521 gagggccctg ggcggcactg tcaccgccac cacatcggtg cgatacggcg acatctccgg
2996581 gccgccgcgc gctcaccagc tggagctacg ggcgtcatgg acggcgacca cccccgatct
2996641 gggcgcccat gtccaggcgt tctgcgacgt cctggagcac gcggccggcc tgccgccagc
2996701 cggggtcacc gacctgggct cgcggtcacg cgcctgacat gtgccccgag ccgtctcacg
2996761 cgggagctgc tgagtccgaa ggcacggaat cggaacccac ccccttgctc cggcccgccg
2996821 gtgggatacc ggatctgtgt gtgaccgtcg gtgaaatcgc cgctgccgca gaactactgg
2996881 accgcgggcg cggaccgttc gcggtagacg ccgagcgggc gtcgggtttc cgctactccg
2996941 gccgcgccta cctgattcag atccggcggg ccgaggccgg caccgtactg atcgacccgg
2997001 tcagccacgg cggtgacccg ttgaccgtgc tggcgccggt cgccgaggtg ctcagcacca
2997061 acgagtggat cctgcactcc gccgatcagg atctgccctg tctcgccgag gtcggtatgc
2997121 gaccgccagc gctatacgac accgagcttg ccgggcgcct ggccgggttc gatcgagtga
2997181 acctggcggc catggtcgag cggttacttg gactgggatt gaccaagggc cacggcgcgg
2997241 ccgactggtc caagcgcccg ctaccctcgg cctggctgaa ctacgcggcg ttggacgtgg
2997301 aactgctcat cgaactacgc gcggcgatct cgcgggtgct ggccgagcaa ggcaaaaccg
2997361 attgggctgc gcaggaattc gagcacctgc ggtcgttcga atcaaggcca cccccagcgg
2997421 ccgcccggca ggaccgctgg cgacgaacct cgggtatcca caaagtgcat gaccggcggg
2997481 ggctggccgc ggtccgcgaa ttgtggacag cgcgtgaccg aatcgcccag cgccgcgaca
2997541 tcgcgccccg ccggatcttg ccggactcgg ccattatcga tgccgccatc gccgacccaa
2997601 agtcagtcga cgaccttgtc gcgttaccgg tgttcggcgg acgcaaccaa cgtcgcagcg
2997661 cggctgtgtg gtgggcggca ctggcagccg cacgcgaaag cccagatccg ccggagatcg
2997721 ccgaaccggc aaacgggccg ccgccgccgg ggcggtgggt cagacggaaa ccggcagccg
2997781 ccgcacggct ggatgcggcg cgcgcggcgc tgacggaggt gtcgcaacgg gtgcgggtac
2997841 cgaccgagaa cctggtctca cctgatctgg tgcgacggct gtgttgggaa tgggaggaca
2997901 tctcgcagag ttctccagac ccgattgccg ctgtcgaggc gtacctgcgc accggccagg
2997961 cacgggcctg gcagctcgaa ctagtggtcc ccatcctgac cgcggcgttg acaggggctc
2998021 cggacgccgg cgcccagggc gatgatggct cttagtcgag atgttctgga atcgcgtcgg
2998081 acgcacacac cccggtaccc agcgcggcga cccagccggt gatccgccgg gccacgtcct
2998141 ggtcggtaag ccccagatcg gccagcacct cgcttcgaga cgcgtgctcg tagaactcct
2998201 gcggcaaccc gacatcgcgg cagggcacgt cgatctccgc gcgccgcagc gcggccgaca
2998261 ccgctgaccc cgccccaccg ttgaccccgt tgtcctctag cgtgacgagc agcttgtgct
2998321 gcaccgccag ttcgcgcaca ccgtcagaca ccggcaacac ccagcgcggg tcgatcaccg
2998381 tcacaccgat cccctggttg tgcagccgct tggccaccgc caacgccatc ggtgcgaacg
2998441 cgccgatggc caccaacagg acgtcgtggt tcaaaccatc ggcgggcgcc gccagcacat
2998501 ccacgcctcc acgccgctcc aaagccgaaa tatcttctcc cacatcacct ttggggaacc
2998561 gtaacgccgt cgggccgtcg tcgacgtcga gcgcctcgcc gagttcttca cgcaaccggg
2998621 tggcgtctct gggcgctgcc acccggatgc cgggcacgat acccagcatc gacaagtccc
2998681 acattccgtt gtggctggcg ccgtcgctac cggtgatccc ggcacggtcc agcaccatgg
2998741 tgaccggcag cttgtgcagc gccacatcca tcatgatctg gtcgaacgcc cggttcagga
2998801 acgtcgagta gatcgccacc acggggtgca gcccacccat cgccaacccg gccgccgacg
2998861 tcatcgcgtg ttgctcggcg atcccgacgt cgaacaatcg atccgggaag cgctgcccga
2998921 acgcggtcag cccggtgggg cccggcatgg ccgcggtaat ggccacgatg tcacggcgtt
2998981 tctgggcgta gccgataagt gcatcagaga aggtcgccgt ccagcctggg ccggccacct
2999041 tggtggcttg tccggtggcc ggatcgatcg ggaccgtgga atgcatctgc tcggcctggt
2999101 cggcctcggc cggcgggtag cccatgccct tgcgggtgac gacgtgcacg atcaccggtg
2999161 caccgaagcg ccgcgcgctg cgcagcgcga cctccaccgc ccgctcgtca tggccgtcga
2999221 ccgggccgac gtacttcaac ccgaggtcgg tgaacagcaa ctgcggcgac agcgagtcct
2999281 tgatgccggc cttgacgctg tgcaggaatc gaaaccacag accgccgaca agcggcaccg
2999341 cgcgcaccag gtcgcggccc gtctccagcg cctgctcgta ggccggctgc agccgcagcg
2999401 tggccagatg gtcggcgacg cccccgattg tgggcgcgta gctgcgccca ttgtcgttga
2999461 ccacgataat caccggccgg cgggatgcgg cgatattgtt cagcgcctcc cagcacatac
2999521 cgccggtgag cgcaccgtca ccgaccaccg cgaccacatg ccggttgcgg tgtccggtca
2999581 actcgaacgc cttggccaac ccgtccgcgt acgacagcgc cgcgctggcg tggctcgact
2999641 ccacccagtc gtgctcgctc tcggcacgag acggataccc cgacaacccg cccttcttac
2999701 gcagggttgc gaagtcctgg ctgcgtccgg tcaacatctt gtggacgtag gcctggtgac
2999761 cggtgtcgaa gatgatcgga tcgtgcggcg agtcgaatac ccggtgcagc gccaaggtga
2999821 gttccaccac tcccaggttc ggccccagat gcccccccgt ggcggcaacc ttgtggatca
2999881 ggaactcacg gatctcggcg gccagctccc gaagctgcgc ctgggaaagg tgctgcagat
2999941 cagcgggccc gcggatctgt tgcagcattt cgctagtgta cgcagcaacc cccccattgg
3000001 cccagcatgc ggccgccgat caaaagggcc gaaccacttt gatagcgtcg gtggccggcg
3000061 cgccgggaag cctggtcggc gactcattgt catccaactc cggagttcga tatgaaggta
3000121 aacatcgacc caaccgcgcc cacctttgcg acgtatcgtc gggatatgcg tgccgagcaa
3000181 atggcggagg actatcccgt cgtaagcatc gattccgacg cgctggatgc tgcccgcatg
3000241 ctcgcagagc atcgtctgcc tggactattg gtcaccgccg gagcgggcaa acagtatgcg
3000301 gtactccctg cctcacaggt cgtgcgcttc atcgtgcccc gctatgtgca agacgatccc
3000361 ttactggccg gtgtgctcaa cgaatcgacg gccgaccggt gcgccgagag attgagcggc
3000421 aaaaaggtcc gcgacgtgtt gcctgaccac ctggtcgagg ttcccccggc taacgccgac
3000481 gacaccatca tcgaggtggc cgcggtgatg gcacggctgc gcagcccatt gctcgcggtg
3000541 gtcaaagacg gctcgctgct cggggtggtc accgcatcgc gcctgcttgc tgcggcactg
3000601 aagacttgac ctcgtgagcg tcgtcgcggt caccatcttc gtggcggcct acgttctgat
3000661 tgccagcgat cgcgtcaaca agacgatggt ggcgctgacc ggcgcggcgg ccgtggtcgt
3000721 cctaccagtg atcacatccc acgacatctt ctattcccac gacaccggaa tcgactggga
3000781 cgtcattttc ttgttggtgg gcatgatgat catcgtcgga gtgctgcggc agacgggggt
3000841 gttcgaatac accgcgatct gggccgccaa gcgcgcccgc ggctcgccgc tacgcatcat
3000901 gatcctgctg gtattggtga gcgcgttggc gtcagccttg ctggataacg tcaccacggt
3000961 gttgttgatc gcgccggtca cgctattggt gtgcgaccgg ttaaacatca acacgacgtc
3001021 gttcctgatg gccgaagtct tcgcctccaa cattggtggc gccgcgacgt tggtgggtga
3001081 cccgccgaac atcatcgtgg ccagccgggc gggattgacg ttcaacgact tcatgctgca
3001141 cttgacaccg ctggtagtca ttgtgctgat cgccctcatc gctgtgctgc cccgcctgtt
3001201 cggctcgatc acggtcgaag ccgatcgaat tgccgatgtc atggcgctcg acgagggtga
3001261 agccatccgc gaccgcggac tgctggtcaa atgtggcgcc gtgctggtgc tggtgttcgc
3001321 ggccttcgtc gcccatccgg tgctgcacat ccagccttct ctagtggcgc tgctgggcgc
3001381 tgggatgctg atcgtggtct cgggtctgac gcgatccgag tatctatcca gcgtcgagtg
3001441 ggacacgctg ctgtttttcg ccgggctgtt cattatggtc ggagcgctgg tcaagaccgg
3001501 tgtcgtcaac gatctcgcgc gggcagcgac ccagctgacc ggcggcaata ttgtggccac
3001561 cgcgttccta atcctcggcg tctccgcccc gatctcggga attatcgaca acattcccta
3001621 cgtcgccacg atgacgcccc tcgtcgcgga gctggtcgcg gtcatggggg gtcaacccag
3001681 caccgacacc ccctggtggg cgctggccct gggtgccgac ttcggcggca acctgaccgc
3001741 aatcggcgcc agcgcgaacg tcgtcatgct cggaatcgcc cggcgcgcag gagctcccat
3001801 ctcgttctgg gagttcaccc gcaaaggggc ggtggtcacg gccgtctcga tcgcgctcgc
3001861 ggcgatctac ctgtggttgc ggtacttcgt gttgttgcac tgaccatctg tattgccgac
3001921 agacctgtag caccagacga cgccgcgatg agcggcctac gagaagattc ggaggatggc
3001981 cgatgagcat catcgccatc acggtgttcg tagccggcta tgcacttatc gcaagcgacc
3002041 gagtcagcaa gacccgggtg gcactgacgt gcgcggcgat catggtcggc gccgggatcg
3002101 tcggatcgga cgacgtgttc tactcgcacg aagccggaat cgattgggac gtcatctttc
3002161 tgctcttggg catgatgatc atcgtcagcg tgcttcggca caccggcgtc ttcgaatacg
3002221 tcgcgatttg ggccgtcaaa cgcgcaaacg ccgcgccgtt gcgcatcatg atcctgctgg
3002281 tgctggtgac cgcgctgggg tcggccctgc tggacaacgt caccacggtg ttgttgatcg
3002341 cgccggtgac gctactggta tgtgatcgac tgggggtcaa ttccacgccg tttttggtgg
3002401 ccgaagtctt cgcgtccaat gtcggcggcg cggccacgct ggtcggcgac ccgccgaaca
3002461 tcatcatcgc cagccgggcg ggactgacgt tcaacgactt cctgatccac atggccccgg
3002521 ccgtgctcgt cgtcatgatc gccctgatcg gtctgctgcc ctggctgctg ggctccgtca
3002581 ctgccgagcc cgaccgagtt gccgacgtgc tgtcgctcaa cgagcgcgaa gccatccacg
3002641 atcgcgggct gctcatcaag tgcggtgtcg tcttggtgct ggtgtttgcg gccttcatcg
3002701 ctcatccggt gctgcacatc cagccgtctc tggtggcgct gctgggcgcc ggtgtgctcg
3002761 tacggttctc ggggctggag cgatccgact acctgtccag cgtcgagtgg gacaccctgc
3002821 tgttcttcgc cgggctgttc gtcatggtgg gggccctggt gaagaccggt gtcgtcgagc
3002881 aactggcgcg ggcagcaacc gagctgaccg gcggcaacga gttactcaca gtcggtttga
3002941 ttctcggcat ctcggcaccg gtgtccggca tcatcgacaa catcccctac gtcgccacga
3003001 tgacgcccat cgtgaccgaa ctggtcgccg cgatgccggg ccacgtccac cccgacacgt
3003061 tctggtgggc actggcgcta agcgccgact tcggcggcaa cctgaccgcc gtggcagcca
3003121 gcgccaatgt cgtcatgctc ggaatcgccc ggcgctcggg cactcccatc tcgttctgga
3003181 agttcacccg caagggcgcg gtggtgaccg cggtctcgct cgtgttgtcg gcggtctacc
3003241 tgtggctgcg gtacttcgtg ttcggctaag cgccaacgct cacgcgtgct tagcgcgaaa
3003301 gcgccgaaac agcacccaga cgatggccag gttgtagacg gcacccccga cgagatacgg
3003361 ccaccaggtg ccgtgatcgc tggcgaccca aaatgccttg gcagcccagt acggtggtaa
3003421 gacgccgaac gcgaggttcc agttggaact gatgaaccac ggcaggcagg gcagcccggc
3003481 gatgagcatg cccagcgcac ggaccatcgc caggccctga atcttgttgt tcgccaccgc
3003541 aagaatcagc agcagcgtga ccaccgccga caggccggcc accagtccga tgggaatcag
3003601 tgaagacacc aggcccggtt cgaggatccc gctgcacgac atcgtcgcga cgacgtagat
3003661 ggtggtcacc accatcacgg tggccgcacg atagccgaaa aagaccgaca gcggcaccgg
3003721 ggttactcgc agcgccgtca tcgtgcccgc gtctacgtcg tccagcacca agaacgcggc
3003781 cagcgcaccg gcgacgatga tgctggtcaa caacaggaac gcggtgagga tcagtgggta
3003841 gtatccgacc aggtcgaatc cataacgccg cgccagcatc tcggtgaaca gcggcgtgag
3003901 cagcgcgact ccggtggtcc agatgaccgg tgcgatgacg agcatgacca gcagcggatc
3003961 gcggtaggtg cctcgaatgt cgttgcggcc gaacgcggcc aacgcccgtg ggcccgcaag
3004021 gctcgatatc gctctcacag cacacccgat ctttgcacga cataacggcc gaatagcgcc
3004081 ttggccgccc ggcacaatcc cgccgcacac acgattgggt agaccaccgc atacccgacc
3004141 tgccagggcg ccaagctcac ctgatcgaac gccgcgccga gcaagagcag cggcccctgg
3004201 gtggggatga ggtaaagcac cgggttgggc cacaggccgg agtagtgcac caccggcggc
3004261 gccagcatga tcgcgagcgg gatgaccgcc gccaggaacc aatcggtcac cgaggcgaac
3004321 ggcaacgagg aactgaagcc gaccagcagc atcagcagtg tgcccagcac gatgccggcc
3004381 accagcggca gcaggtggta accaagcccg tgaacgatgg tggccacgac aaccgcaacg
3004441 aacagcgaga tcgccagcag cacagttagt ttggcagcca ggtactccca gaaccgcagc
3004501 ggcgtcgaga cgatcgcgcc gatcgtgcgc tcctgcttct cgaagaacac ggtcccgccg
3004561 acgaagaaga acccgatgat cgcgatatca cccaccagga catagggttc ggcgaccggg
3004621 cgcaggctga ccggcatcgg cagcagcact gccagccaaa tcagtccgga gaaaacggcg
3004681 gcatgcaaga acttctgccg cacctgtagc gtcagctcga gccgcagcgc aggcaccaac
3004741 cgggtcatgt cagctgcctg ccggtgacct cgacgaagac atcgtcgagg ctggcctcgc
3004801 ggctatgaat ggtctcgacg tggtggtttc gcagcacgga gtggaacgcc gggtcgtcgg
3004861 caaggccgtc catgccgaac tcggcggtct cgagtccccc gccgtcgccc cggtattcca
3004921 cccgcacccg ccgccggctg cgagcgatct tcagttcggt gggactgtcc agtgcgacga
3004981 tcctgccgtc gacgacgaac gccacccggt cgcacagctc gtcggcggtg gccatgtcgt
3005041 gcgtggtgag aaagatcgtg cggccgcgcg ccttcaggtc cacgatgatg tccttgatct
3005101 tgcgggcgtt caccgggtcc agcccggagg tgggctcgtc gaggaacagc agctccgggt
3005161 cgttgatcag cgacctggcg aagggcagcc gcatctgcat gcccttggag tacttgccca
3005221 ctagggtgtg ggcgtcatcg gccaggccga cggcggccag cagctgcatc gggtcggccg
3005281 tcgcgccggc gtacagcgag gcgaagaagc gcaggttctc atacccggtg agcttttggt
3005341 agtggttggg cagctcgaag gagaccccga tgcgctcgta gtaatcgggt ccccactcgg
3005401 ccggctcttt gtcccacacc gtggcctggc cgccgtggtc gcgcagcagc ccgatgagaa
3005461 gcttctgggt ggtggacttg cccgcgccgc tgggacctag aagcccgaag atttcgccgc
3005521 ggccgacggt gaactccatg ccacgcaccg ccggctcggc cgcctttggg tagcggaagg
3005581 tgagcccgcg cacgcggatc acctcggttc ccacacgcgc cgatgccaca gcacggttga
3005641 gcgccgtcat gattggctcc gttccctttc gggcgagcgc ggtgcgccgg ctcatccaag
3005701 taaccagaaa gtcaccgcgc caatgctgat acctggttcc gaccagtctt cccggagcgc
3005761 caacccaaga ctactagctg cgctgctgta tacggagcaa cccacgacga ccacgggcga
3005821 gctggtcgag cagctgcatg acctctacac ctttcgggtc aacagcgcaa cgcactcgac
3005881 gtagtgagtc agcgggaacg cgtcgaacac cttgatcttc tccacggcgt aaccgtgacc
3005941 acggtagagg ccgatatcgc gcgcgaaaga cgccgcttcg caaccgatat gtatcaaccg
3006001 tggcaccccc gcaccggcca gcaagtcgac aacctcgcgc ccagcgcctg atcgcggtgg
3006061 atccagcacc gccagatccg cgccggcggg ttgcactgcc aacacccgcc gcaccgaacc
3006121 ggtgacgacc tccacctggg gcaaatcgac cagcgcggca cgtgcggccc cggatgccag
3006181 gcgcgaagtg tcgacggtca acacccgtcc ggactccccg accgcctcac ccagcaccgc
3006241 agcgaaaacc cccgcaccac cgtagagatc ccaggcggtc atgccggggg cgggctgagc
3006301 ccagtcagcg atcagatcgc tgtagaccgc cgccgcgtcg cgatgcgcct gccaaaaggc
3006361 cgttaccggc acccgccagc tgcgccggtg cacacgctgg tgggcgtggt aggcgccctc
3006421 caccacgttg gtcacggttc gggtcctatt ccgagggccc tgccgcacgg aacagaccac
3006481 atggcgctcg ccgtcgtcgt ccagagccac gtaaagctgg gcttccggcg gccagtcagc
3006541 cgctaccagg ccgtctagca tgccgacagg caactgcccg cagtccaggt cggttaccag
3006601 ctcgccactg tggtagcggt gaaaacctgg acgacggtct gcgcccacgt cgagccggac
3006661 tcgaatacgc caacccgtgg ggccggcatc cgacagcggt tgcgcctcgc cctgccagct
3006721 gtgccgcccg agccgttcca gctggttagc cacaacttgc gccttaagtg tgcgggccgc
3006781 ctccggagca gcaaacgcca gatcgcaaca cccggcgccg tcggccccgg cgatcgaaca
3006841 cagcgacccg atccggtcgg gcgacgggtc gatcacctcg aaagcctctg cgtgccagta
3006901 agagccacgt tgcgcggtca cccgcgcccg cactcgttca ccgggcaacg catagcggac
3006961 gaaaaccacc cggccctcgt ggtgcgccac gcagctaccg ccgttcgcgg gcgctccggt
3007021 gaccaacgtc agattcactg catcgtcgcc ggcgcgggtc actggcgccg ctcctcccca
3007081 tcgctttgct ctgcatcgtc gccggcgcgg gtcactggcg ccgctcctcc ccatcgcttt
3007141 gctctgcatc gtcgccggcg cgggtcactg gcgccgctcc tccccatcgc tttgctctgc
3007201 atcgtcgccg gcgcgggtca atcgaagatg ccccgtcacg tgtcaccggg agccgcgtgc
3007261 ggctgtaacg tcttgatccg ctccgacgac gtcagttgcc aaggcaccga agtcaccatc
3007321 acgccgggca tgaacagcaa ccggcccttg agccgcagcg cactctggtt gtgcagcagc
3007381 tgttcccacc agcgccccac gacatactcc ggaatgaata ccgtcaccac ggtccgtggc
3007441 gattccttgc tgacccgctt gacgtaatcg agcaccggcc gggtgatctc acggtacggc
3007501 gaggcgatga ccttgagtgg cacgctcaca tcgctgtcct gccactggcg caccagctcg
3007561 cgggtttccg catcgtcgac gttgaccgtc acggcttcca acacgtcggg ccgggtcgct
3007621 cgtgcgtagg tcaacgcgcg caacgtcggc aggtgcagct tcgacaccag cacgacggcg
3007681 tgattgcggc tgggcaacgt tatctcggct tcctcggcct gttccgccaa ctcccggttg
3007741 acggcgtcat agtgcctgtg gatgagcttc atcatcatga agaaccctcc catggcgacg
3007801 atcgcgatcc atgctccggc aaggaatttc gttaccagca cgatgagcag gacggtaccg
3007861 gtggacacga agccgaccgt gttaaccgcg cgggagcgca gcatcgcgcg acgggcgcgc
3007921 ggatcggtct cggcgctcag caaccgggtc cagtgccgga ccatgccgac ctgactcatg
3007981 gtgaacgaga tgaacacacc gacgatgtac agctggatca gcgcggtcaa ctcggcacga
3008041 aacgcgacca ccgccccgat cgccgccgcc gccaggaaca ggattccgtt ggagaacgcc
3008101 agccggtccc cacgggtgtg caactggcgc ggcagatagc tgtgctgcgc cagcaccgag
3008161 cccagcaccg ggaagccgtt gaaggcggtg ttagcggcca acaccaggat cagcgctgtc
3008221 accgcggcga tcagcaagaa ccccaggtaa aagcccccga acacggcctg cgccagttgt
3008281 gcgaccagcg tcttttgctg ataacccggc ggggcgcccg tcagctgggt gtccggatcg
3008341 tcgacgacct ggaccccggt ctctacggcc agcacgatca tgcccataaa catgctcacc
3008401 gcaatgatgc ccagcatcag cagcgtggtt gccgcgttac gcgacttggg cttttgaaac
3008461 gccggcaccc cgttgctgat cgcctcgaca cccgtcagcg ccgcacaccc cgacgaaaac
3008521 gagcgcgcca ccaagaacac cagcgcgaaa ccgacgatct ggccgtgctc tgcgtgcatt
3008581 tcaaaagccg cggactcggc ccgaaccgga ttgcccagca cgaaaatccg gaacaacccc
3008641 cacacgagca tggtgccgat tccggcgatg aacgcatagg tcgggatcgc gaacgccaac
3008701 ccggattccc gaaccccacg caagttcatc gccatgatca gcacgatcgc gccgacggca
3008761 aacaacacct tgtgctcgta cacgaacggg ctcacagagc cgatgttgga cgccgccgac
3008821 gatatcgaaa cagcaacggt gagaacgtaa tccaccatca gggcgctggc aaccacgaga
3008881 ccgccggtag cacccaggtt ggtggtgaca acctcgtagt cgcccccacc ggaggggtaa
3008941 gcgtgcacgt tctgccggta actagacacc accacgagca gaaccgcggc gaccgccagg
3009001 ccgatcaacg gcgccatcga ataggccgcc aggccggcca ccgagagcac cagaaatatc
3009061 tcctcggggg cgtaggctat cgacgacatc gcatccgagg cgaacaccgg caaggcgatc
3009121 cgcttgggca acaaggtgtg actgagccgg tcactgcgaa acggccggcc gatcagcaac
3009181 cgacgcgccg cggttgaaag tttggacacg agagccaagg gtaggcctat ccgagcgtgg
3009241 cggtagcgtt ccctagacga gaatgttcgc cgacgtaaat cggctggcca ccgcgggttg
3009301 ccgatcgcgt acggcgcacc ggacacagcc gagaggacct ctaatgcggg tggttgtgat
3009361 ggggtgcggc cgggtcgggg cttcggtggc cgacggactg tcccggatag gccatgaagt
3009421 cgcgatcatc gaccgtgaca gcgccgcctt caatcggctc agcccgcagt ttgccggcga
3009481 gcgggtgttg ggtcagggct tcgaccgaga tgtgctgctg cgtgcgggca tccagggggc
3009541 cgacgcattc gccgcggtgt cctccggcga caactccaac atcatctcgg cgcggttggc
3009601 ccgggaaacc ttcggtgtgc cgcgcgtcgt cgcgcggatc tatgatgcca agcgcgccga
3009661 ggtctatgag cgactcggca tccccaccat taccaccgtt ccctggacca ccgatcggct
3009721 gctcaacgcg ctaatgcagg acaccgaaac cgccaagtgg cgcgatccta ccggtaccgt
3009781 cgcggtcgcc gaggtcgtct tacacgaaga ctgggtgggc caccgggcga ccgatcttga
3009841 gcaggccacc ggcgctcgga ttgcgtttct gatccgattc ggaaccggtg tattgccgga
3009901 accgaagacg gtcctacagg ccggcgataa ggtctatatc gctgcgatat ccggccgggc
3009961 cgcagaggca gcggccatcg cagccttgcc acccagtgag gacttcgagt cgggggctcg
3010021 acgatgaaag tagctgtcgc cggagcgggt gcggtgggcc gctcggtcac ccgcgaactc
3010081 gtggaaaacg gacacgacat caccctgatc gagcgcaacc ccgaccacct cgacgccgcc
3010141 gccatcccgg aggcgcattg gcggcttggc gatgcctgcg aactgagcct gctggagtcg
3010201 attcacctcg aagagttcga cgtggtcgtc gccgccaccg gggacgacaa ggtcaacgtg
3010261 gtgctcagcc tgctagccaa gaccgaattc gcggtgccgc gggtggtggc ccgggtcaac
3010321 gatccccgca acgagtggct gttcaacgac gcctgggggg tcgacgtcgc ggtgtccaca
3010381 ccccgcatgc tggcgtcgct gatcgaagag gccgtcacga tcggcgactt ggtgcggctg
3010441 atggagttcc gcacgggtca ggccaatctg gtagagatca ccctgcccga caacacgccg
3010501 tggggcggca aaccggtgcg caaacttcag ctgccgcggg atgccgcgct ggtgacaatc
3010561 ctgcgcgggc cacgagtcat cgtgccggag gccgacgagc cgctggaagg cggcgacgag
3010621 ttgctcttcg tcgcagtcac cgaagccgag gaggagctga gcaggctgct gctgccgtcc
3010681 atgtaaccgg cgggctctac tcgcggccgg cgtcggcgtc gaattcagct gcacctccga
3010741 cggccgcggc gtcgtgagag gccaagatgg cgcgctgggc tgccttgatt gccgcgtagg
3010801 tggccagcgc ggcgagggcg gtcagcggcc aacccatccc gatcctggcc actcccagcc
3010861 aacccgtctt atcggcgtcg tagaggtgcc tttggacgat gaaccgggca gcaaaaacca
3010921 gcgtccaacc cagggtggcg acgtcaaacg caaagacagc gcgggacacg tcgcgccagg
3010981 cgcgatcgcg cccgctgagc cagctccaca agtagccgac tatcggccgc cggatcagga
3011041 tcgacagtgt gaagaccacc gcccacagca acgacatcca gatgcccagc aggaagtacc
3011101 ccttggactg tcccaccagg tacgcgatca gcgcgcacac ggctaccccg cagaatccgg
3011161 caaccaccgg ccgcgcagat tcccggcgca aaagccgcca cagcaggatc aaccccgcca
3011221 tgctcagggc gaacccaatc gcgggcagca agccggcggc gctggaagca accacaaaag
3011281 tcaccaccgg taatgacgaa tagaccaggc cgctcactcc gccggcctgc gccaacaggc
3011341 gctgggcgct agtgcggtta gcgttcacga gacaccggca attccgactg ccggatagtc
3011401 accgctgaat ttcgtaatgc gggttgtaga tagccttcgt cccattttcc agcttgccca
3011461 gccggccgcg cacccgcagg gtacggcccg tgtcgatgcc gggtatccgg cgttgaccca
3011521 accacaccag cgtgacggtg tcgctgccgt cgaacaattc ggcgcgaaca ccacccgagc
3011581 aacccttgcc attggtttcc acgctacgca gggtgccaac caccgtgacc tcctggccgc
3011641 gctggcagtc gatcgcacgc tgtgcgccgg cattgagcac ctcgtcggat aactcttcga
3011701 cgtcgcgttg ctccaggtcc tccgtcaacc gacgggtgag cctgcgcaga taaccctggg
3011761 cccccatggc ctctcctgac acgtcaccta cgttatggaa gtttcgtgca actgccggcg
3011821 tattccacct atgccaacgg ccaccgtaga cctgttggtt cccgggcgcc accgttggcc
3011881 ttggagcacc ccaaagtggc gggcactatc aagggatggc tgtcgatttg gatggggtca
3011941 caaccgtgtt gttgccggga accggatcgg acaacgacta cgtccggcga gcattttccg
3012001 cccccctgcg acgcgccggg gcggtgctgg tgacgcccgt tccgcatcct ggtcgcttga
3012061 tcgacggcta tcgcgccgcc ctggacgacg ccgcgcgcga cgggccggtt gtcgtcggcg
3012121 gcgtctcgct cggagccgca gtggcggcgg cgtgggcgct ggaacatccc gatcgcgcgg
3012181 tcgccgtcct ggccgccttg ccggcctgga ccggggaacc tgaattagca cctgccgcgc
3012241 aggcagcgcg gtatacggca gcgcggctgc gctgcgacgg tctggcggcg acgaccacac
3012301 gcatgcgtgc atctagcccc gtctggttgg ccgaggagct gacccgatcg tggcgagttc
3012361 agtggcccga gctgcccgat gctatggagg aggcggcggc ctatgtcgcc ccaagccgcg
3012421 ccgagctggc ccggctggtc gcgccgctgg ccgtggccgc ggcggtcgat gatccgatcc
3012481 acccgctgca ggtcgctgcc gactgggtgt ccgtagctcc gcatgcggcg ctacggacgg
3012541 tgacgctgga cgagatcggc gcggacgccg ccgcgctggg ctctgcctgc ctggccgctc
3012601 tcgccgaggt ctcgggcgct tgatcgcctg tttgtccgac ggcggagtgc gcgtaccgtt
3012661 tgggtcgccg agcctgtaat tttgcaggcc cccactcgca ctttgcctgc agagttacag
3012721 cctcagcgaa cagcgcgctc gtactgttga ggtcgtcgag ctagtcccga tcgcccgact
3012781 cctcctcacg ccgctacgcg gcgcgctcgt actgttgggg tcgtcgggct agccgcccgt
3012841 cgtgctgcgc aactgctgca tcgccgatcc ttgagcgccg cggcgtgcaa cccccgcggc
3012901 ggcttggcgt tgcgtgtcgg cctgtgccgc cgcagcctcc cttagttgcg ccgccatcgg
3012961 ctcgggcagg tgcaccggta acggcgtccg taccggcagc ggggtatcgc cccggcggac
3013021 cacggtgtcc gccaacgcct cacgggcctc ctcggtcagc gcatcgactg tctcttgtgg
3013081 gccgttgacg acgcatcgga tcatccagcg gtagccgtcg accccgatga agcgcaccac
3013141 accggcggcg atgccgatca cttcgcgacc ccacgggcca tccttgatcg aaactttggc
3013201 cgagtccttg cgcagcgagt cggcgagttc gccggccacc tcacgccaga gcccgccggt
3013261 cttaggtgcc gcgtaggccg caatgctgta gcgaccgttg ggtgtgatga cccacaccgc
3013321 gctgggaaca ccgctctcgg tcagctcgac ctgtacctga cccgcggccg gcatcggaat
3013381 cagcaccgag cccaagtcca gccgggccag caccgccacc gaagggtcat cgaagtcgtc
3013441 gatgtcgaat gggccctgaa gctcctcctg gtcttcgacg cctgacgcgg cggcagcgct
3013501 ggccaccacg gtgtcctccg gtcggacgtg ctcgtcggcc ggctggacgg gggcgtgtcc
3013561 ggccttgcgt ttgccaccgt ctttgcctgt gcgtctaccg aatgccatgg cgagcgccgc
3013621 tctcccccgt aagcgggtgg tacccccacc tcatcgcgcc ctcctttgca tcgtcgccgg
3013681 ggtcacaaac tcgcatgtcc gccggaggaa ccgtggccac cgtcgccgcg ggatgtcgag
3013741 gccagcccgg cctcgtcgaa cgacgagacc tcgaccagct cgaccaactc aacccgttgc
3013801 actagcaact gggcgattcg gtcaccgcga tgtaccacga tgggcgcggc tgggtccaag
3013861 ttgatcaggg ccaccttgat ctccccacga taacccgcgt cgatggtgcc cggactgttg
3013921 acgatcgaaa gccccacccg cgtggccaac ccggagcgcg gatggaccag cccgaccatg
3013981 ccgaacggga cggcgaccgc aacacccgtc cgtaccaggg cgcggcgccc aggtgccagc
3014041 tcgacgtctt cggcgctgta gagatcaacg ccggcgtcgc cgtcgtgagc gcggctgggc
3014101 agcgggagcc cggggtcgag gcggacgatc gccagagtgg tcgacacggg gccacagact
3014161 acccttgacc gcgtgtctgg gacgcgcctc gcgccgcaca gcgtgcgata ccgcgagcga
3014221 ttgtgggtgc cctggtggtg gtggccattg gctttcgcgc tagcggcgct tatcgcgttt
3014281 gaagtaaacc tgggcgttgc ggccctaccc gactgggtac cgttcgcaac gcttttcaca
3014341 gtcgcagccg ggacgctgct atggctcgga cgtgtcgaaa ttcgggtcac cgccggctca
3014401 gcggatggag ccggagtgaa gctatgggcc ggaccagcgc atctgccggt agccgtgatc
3014461 gcccgatcag ccgaaatccc ggccacggct aaatctgcgg cgctgggccg acaactcgat
3014521 ccggcagctt acgtcctgca tcgggcctgg gtggggccca tggttctggt tgtcctcgac
3014581 gaccccaacg atcccacgcc gtactggttg gtgagctgcc gccacccgga gcgggtgttg
3014641 tcggcgctgc gcagctgacc tatcaggcgg cgcagtcggt gcagatcatc acgccgttct
3014701 tctcgctggc caacctgctg cggtgttgca ccaaaaagca actcgagcag gtgaattcgt
3014761 cagcttgctt gggtacgacg cgcaccgaca gttcttcgcc ggacaggtcg gcgccaggca
3014821 gttcgaagga ctcggcggat tcggattcgt ccacgtcgac cacggccgac gccgcctcgt
3014881 tccgtcgtgc tttgagctct tcaagcgagt cctccgagac atcatcggtc tcggtacgcc
3014941 gcggagcgtc atagtcggta ggcattccta tcccctcaca tgcctcataa cttcaagcaa
3015001 cgctttgtac cagcgtcgaa cgcgtccacc aaacgattcg tgcccgtatc gtggcctatt
3015061 caagtgtgat ttacatcaca tattcatatt gcaccttgta cgcggcccta aacggtgcct
3015121 ttttgggtgc gaactacacc caatggtccg cctcctcacc gcgccgtgcc ggcacgcgtc
3015181 gtcagcggat taaagtgcac gtgtggtcgc acaaatcacc gagggtaccg ctttcgacaa
3015241 gcacggacgg ccctttcggc gacgcaaccc ccgacccgct atcgtcgtgg tggccttcct
3015301 cgtggtggtg acttgcgtga tgtggactct tgcactgacg cggcccccag atgtccgcga
3015361 ggccgcagtc tgcaacccgc ctccgcagcc ggcggggtca gcaccgacca accttggtga
3015421 acaggtgtcg cggacggaca tgaccgatgt cgcacccgcc aaactgagcg acaccaaagt
3015481 ccacgtcctc aacgccagcg gccggggcgg ccaagccgcc gatatcgctg gcgcactgca
3015541 agatctgggc ttcgcccagc cgaccgccgc caacgacccg atctatgccg gcacccggct
3015601 ggactgccaa ggccagatcc gcttcggtac ggcggggcaa gccaccgctg ccgcactatg
3015661 gctggtagcg ccgtgcaccg agctgtatca cgacagccgc gccgacgatt ccgtcgacct
3015721 tgcgctcggc accgacttca ccacgctggc acacaacgac gacatcgacg ccgtgcttgc
3015781 caacctgcgc cccggcgcca ccgagccctc agatcccgcg ctgctggcca agatccacgc
3015841 caacagctgc tgatcggccg gctcagtccg ggatcggctc taggccgttg aatcgctgta
3015901 gcgccgccaa cagctcgtcg gcgattccgg gcgcggcagc caccaccacc aaccccgcgc
3015961 cgcccgctct cggcgttgac aacaacacgc gggcccccgc ctcagcggcg atcaacgcac
3016021 ctgccgcaca gtcccacacc tgcaccccgt gctcgtagta ggcgtccagc cgacccgccg
3016081 ctaccatgca caagtccagc gccgcagaac cgatccgacg cacgtcgcgg accaacggca
3016141 caacatgagc cagcaattct gcctgcttct cgcggcaccg aaccgagtac ccgaagccgg
3016201 tacccagcaa cgccatcgac aactcgtcga caccggtgca ccgcaacaca tgtctccccc
3016261 gctcatcggt gagatgtgcg ccgaggcccg tcgccgccga atacaccgtg cgagcggcga
3016321 cgtcggcgac cgcgcccgcc accgtgatgc cgccaacctg tgccccaatc gacaccgcgt
3016381 acgccgggat gccgtagacg aaattcaccg tgccgtcgat ggggtcgagc acccaagtga
3016441 cccggtcgga gggtgtagcc gtcacgtcgg cgggaccacc accttcctcc ccgagaatcg
3016501 ggtcaccggg ccgaagttga gccaaccgat cacgcaagag ccgctccgtg tcggtgtcga
3016561 ccacggtcac cggatcggtc gggctgctct tcgcgcgcac cgcgccgtcg ccgtcgcccg
3016621 ccctggagat gccgaaaacc tcggcccgac gaccgcgaac gaaggccgcc gcctcggcag
3016681 caaggttttc ggccacagag cgcagccgcg cgggttcgtt gtcaggtcgt gtcaccggcc
3016741 tatcgcatca cagtcgccac ccgcatggtg gcgtggactc cagcggccat aacgccctcg
3016801 caactgccgg gccgcagttt aaggtgaggg tcatccacgt ctcgccgagg agattcgatg
3016861 accagcaccg gccccgagac gtccgaaaca ccgggtgcca cgacacagcg tcatggcttc
3016921 ggcatcgacg tcggcggcag cggcatcaag ggcggaatcg tcgacttgga caccggccag
3016981 ctgatcggcg accggatcaa gctgctgacc ccgcaaccgg ccactccgtt ggcggtcgcc
3017041 aaaaccatcg ccgaggtcgt caacggtttc ggctggcggg gtccgctggg ggtgacctat
3017101 cccggcgtcg tcactcacgg cgtcgtccgg accgcggcta acgtggacaa gtcctggata
3017161 gggaccaacg cacgcgacac tatcggcgcc gagctgggcg gtcagcaggt caccatcctc
3017221 aacgacgctg atgccgccgg gctggccgag acacgctacg gggccggcaa gaacaaccct
3017281 ggcttagtgg tactgctcac attcggaacc gggatcgggt ccgcggtcat ccacaacggg
3017341 acgttgatac ccaacaccga gttcggacat cttgaggtcg gcggcaagga agcggaggaa
3017401 agggccgcct cctcggtaaa ggaaaagaac gactggacct atccaaagtg ggccaagcag
3017461 gtgatacgcg tgctcatcgc catcgagaac gcgatctggc ctgacctgtt catcgccggc
3017521 ggcggcatca gccgcaaggc cgacaaatgg gtgccgctac tggaaaaccg cacaccagta
3017581 gtgcccgcgg ccctgcagaa caccgccgga attgtcggtg cggccatggc ctctgtcgca
3017641 gatacgacgc actgaaactt gcccgctcgg gctgtactcg tgcgcagtaa agttacaatg
3017701 gtcagcggcg gccgcccgac cgatagcgcg cgagtattca cgctgatatc aacgccgaca
3017761 ttcgacatag cagacacttt cggttacgca cgcccagacc caaccggaag tgagtaacga
3017821 ccgaaggggt gtatgtggca gcgaccaaag caagcacggc gaccgatgag ccggtaaaac
3017881 gcaccgccac caagtcgccc gcggcttccg cgtccggggc caagaccggc gccaagcgaa
3017941 cagcggcgaa gtccgctagt ggctccccac ccgcgaagcg ggctaccaag cccgcggccc
3018001 ggtccgtcaa gcccgcctcg gcaccccagg acactacgac cagcaccatc ccgaaaagga
3018061 agacccgcgc cgcggccaaa tccgccgccg cgaaggcacc gtcggcccgc ggccacgcga
3018121 ccaagccacg ggcgcccaag gatgcccagc acgaagccgc aacggatccc gaggacgccc
3018181 tggactccgt cgaggagctc gacgctgaac cagacctcga cgtcgagccc ggcgaggacc
3018241 tcgaccttga cgccgccgac ctcaacctcg atgacctcga ggacgacgtg gcgccggacg
3018301 ccgacgacga cctcgactcg ggcgacgacg aagaccacga agacctcgaa gctgaggcgg
3018361 ccgtcgcgcc cggccagacc gccgatgacg acgaggagat cgctgaaccc accgaaaagg
3018421 acaaggcctc cggtgatttc gtctgggatg aagacgagtc ggaggccctg cgtcaagcac
3018481 gcaaggacgc cgaactcacc gcatccgccg actcggttcg cgcctacctc aaacagatcg
3018541 gcaaggtagc gctgctcaac gccgaggaag aggtcgagct agccaagcgg atcgaggctg
3018601 gcctgtacgc cacgcagctg atgaccgagc ttagcgagcg cggcgaaaag ctgcctgccg
3018661 cccagcgccg cgacatgatg tggatctgcc gcgacggcga tcgcgcgaaa aaccatctgc
3018721 tggaagccaa cctgcgcctg gtggtttcgc tagccaagcg ctacaccggc cggggcatgg
3018781 cgtttctcga cctgatccag gaaggcaacc tggggctgat ccgcgcggtg gagaagttcg
3018841 actacaccaa ggggtacaag ttctccacct acgctacgtg gtggattcgc caggccatca
3018901 cccgcgccat ggccgaccag gcccgcacca tccgcatccc ggtgcacatg gtcgaggtga
3018961 tcaacaagct gggccgcatt caacgcgagc tgctgcagga cctgggccgc gagcccacgc
3019021 ccgaggagct ggccaaagag atggacatca ccccggagaa ggtgctggaa atccagcaat
3019081 acgcccgcga gccgatctcg ttggaccaga ccatcggcga cgagggcgac agccagcttg
3019141 gcgatttcat cgaagacagc gaggcggtgg tggccgtcga cgcggtgtcc ttcactttgc
3019201 tgcaggatca actgcagtcg gtgctggaca cgctctccga gcgtgaggcg ggcgtggtgc
3019261 ggctacgctt cggccttacc gacggccagc cgcgcaccct tgacgagatc ggccaggtct
3019321 acggcgtgac ccgggaacgc atccgccaga tcgaatccaa gactatgtcg aagttgcgcc
3019381 atccgagccg ctcacaggtc ctgcgcgact acctggactg agagcgcccg ccgaggcgac
3019441 caacgtagcg ggcccccatg tcagctagcc gcaccatggt ctcgtccgga tcggagttcg
3019501 aatcagccgt cggctactcg cgcgcggtac gcatcgggcc actcgtggtg gtggccggaa
3019561 cgaccggcag cggcgatgat atcgccgctc agacgcgaga cgctctgcgc cgcatcgaga
3019621 ttgcgctcgg acaggccggc gcaactctgg ccgacgtggt ccgtacccgc atctatgtga
3019681 ccgatatttc ccgctggcgc gaggtcggcg aagtgcatgc acaggctttc ggcaagatcc
3019741 gtccggtgac gagcatggtc gaggttaccg cgctgattgc gcccggcctg ctggtagaga
3019801 tcgaggccga cgcctacgta gggtcggcgg ttgcagaccg aaattcggga gccggcccga
3019861 aggacccgtc accagccggt gggtaggcgg cggccccaat cacagcgcgc accggcagtg
3019921 ggccgtagag atgcgggaaa agcatcgacc gcggatcagt aggcacgccc ggctcccaac
3019981 gcacgggtga gtcgagcgcc gccgggtcga tgtacagcag caccaggtca gcacggccac
3020041 ggtaaaggcg gttggcgggc aggtgaacct gctcgagtgt cgacaggtgg atataccccg
3020101 tcttgtcgga ctcgggatag atcccaccgc gttctcgggc atgcgaccac tcctgcaccc
3020161 cgcataggtg caccagcatg gcaggatcgg gcgtcattct caccaccctg cccgattggc
3020221 gggggcgaaa gtcgtgagaa atgacacacc cgacagcggc cggggaacac ggcgagaacc
3020281 ccgaacgtct gagaaggtga agatacccga gaacggagag ccatgaacgc aactctgacc
3020341 agtcctgagc tgactagagc agaccgctgc gaccgctgtg gcgctgcagc tcgggtgcgc
3020401 gccaagctgc cctccggagc cgagcttctt ttctgccagc atcacgccaa cgagcacgag
3020461 gcgaaactga ccgagatgtc cgccgtgctg gaggtcagcg ggagcgaata gaccgaactc
3020521 acccgtccac aatgccggta gcgcgcgcag ttttcggtaa tgctggactg gtatgagcga
3020581 ccaggtcccc aagccacacc gccaccacat ctggcgaatc acccgtagga ctttgtccaa
3020641 aagctgggac gactcgatct tctcggagtc agcgcaagcg gctttttggt cggccttgtc
3020701 tttgccgccg ctactgctgg gaatgctggg cagtctggcc tacgttgctc cgctattcgg
3020761 cccggacacc ttgcccgcga ttgaaaagag cgcgctttcg acggcccaca gctttttctc
3020821 ccccagtgtg gtcaacgaga tcatcgagcc caccatcggc gatatcacca acaacgcccg
3020881 cggtgaggtg gcgtcgctgg gcttcttgat ctcgctgtgg gcaggatcgt cggcaatctc
3020941 ggcgttcgtc gatgcagtgg tggaagcgca cgaccagaca ccgctacgcc acccggtccg
3021001 gcaacgcttc tttgcgctct tcctctacgt ggtgatgttg gtgttcctag tagcgaccgc
3021061 accggtaatg gtggtgggtc cacgcaaggt aagcgagcac atcccggaga gcttggccaa
3021121 cctgctgcgc tacggctact accccgcgct tattctcggt ctaaccgtcg gggtcatcct
3021181 gctataccgg gtggcactac cggtacccct gccgacgcat cggctggtcc taggcgcggt
3021241 gcttgcgata gcggtcttcc tgatcgccac cttgggcttg cgggtctacc tcgcgtggat
3021301 cacccgcact ggctacacct acggagcgct ggccacgccg atcgcgtttc tgttattcgc
3021361 cttctttggc ggctttgcga tcatgctcgg cgctgaactc aacgccgccg tccaggagga
3021421 atggccggcg ccggcgacgc atgcccaccg actgggcaat tggctaaagg cccgcatcgg
3021481 cgtcggcacg acgacgtatt cttcgacagc ccagcacagc gccgtcgctg ccgagccgcc
3021541 gagctagtca gcccttcttg agggtgtcgt aaatccgctt gcaatcggga cagaccggcg
3021601 agcccggctt gggcgcgcgg gtaacgggaa acacctcgcc acacaacgcc accacgtggc
3021661 tacccatgac cgcgctctca gcgatcttgt ctttcttgac gtagtggaag tatttcggtg
3021721 tgtcgctgcc ggtcccgtcg tcgacgcgtt cgtcggcgtc ggtacgttca atcgtctggg
3021781 tctgcatacc tgacattgtg cccttggcag gaaagctctc gaagccggag tgcactgcat
3021841 gtgggacagt agagtaatga agcacggctt gaggctgggt ttcaatggcc agttcgacga
3021901 cttcgacgac ttcgacgata agggccggcc ggtactgatt actgccgccg ctccctcgta
3021961 tgaggtggag catcgcacac gggtgcgtaa gtacctgacc ctgatggcat tccgggtccc
3022021 cgcgctcatt ctggccgcca tcgcctacgg cgcctggcac aacggactga tctcgctact
3022081 gatcgtggca gcctcggtgc cgttgccatg gatggccgtt ctgatcgcta acgaccgacc
3022141 gccgcgccgc gccgacgaac cccgccgctt cgacgtcgcc cgccggcgca tcccgctgtt
3022201 cccgaccgcc gaacggcccg cactcgagcc gcggcgacag ccggcagagc ggtcagcccc
3022261 gcggggattc gccgaccacg gttagccgtc tgttggccgg cgttccgggt tgtcggccac
3022321 tggccacact tctcaggact ttctcaggtc ttcggcagat tcctgcacgt cacagggcgt
3022381 cagatcactg ctgggtggga actcaaagtc cggctttgtc gttaaacccc atgacagtgc
3022441 aagccgatcg ggaggtcgct atggccgatg cacccacaag ggccaccaca agccgggttg
3022501 acagcgatct ggatgctcaa agccccgcgg cggacctcgt gcgcgtctat ctgaacggca
3022561 tcggcaagac ggcgttgctc aacgccgccg gtgaagtcga actggccaag cgcatagaag
3022621 ccgggttgta tgccgagcat ctgctggaaa cccggaagcg cctcggcgag aaccgaaaac
3022681 gcgacctggc ggccgtggtg cgtgatggcg aggcggcgcg ccgccacctg ctggaagcaa
3022741 acctgcggct ggtggtatcg ctggccaagc gctacacggg tcggggcatg ccgttgctgg
3022801 acctcatcca ggagggcaac ctgggtctga tccgagcgat ggagaagttc gactacacaa
3022861 agggattcaa gttctcaacg tatgccacgt ggtggatccg ccaggccatc acccgcggaa
3022921 tggccgacca gagccgcacc atccgcctgc ccgtacacct ggttgagcag gtcaacaagc
3022981 tggcgcggat caagcgggag atgcaccagc atctgggtcg cgaagccacc gatgaggagc
3023041 tcgccgccga atccggcatt ccaatcgaca agatcaacga cctgctggaa cacagtcgcg
3023101 acccggtgag tctggatatg ccggtcggct ccgaggagga ggcccctttg ggcgatttca
3023161 tcgaggacgc cgaagccatg tccgcggaga acgcggtcat cgccgaactg ttacacaccg
3023221 acatccgcag cgtgctggcc actctcgacg agcgtgagca ccaggtgatc cggctgcgct
3023281 tcggcctgga tgacggccaa ccacgcaccc tggatcaaat cggcaaacta ttcgggctgt
3023341 cccgtgagcg ggttcgtcag atcgagcgcg acgtgatgag taagctgcgg cacggtgagc
3023401 gggcggatcg gctgcggtcg tacgccagct gaagctggac atcctgagcc aggtagcaga
3023461 cggtatgccc gccgcgccag cggcgggcat accgctgcgg tggggcggcg ggcaaccatt
3023521 ttcgcagctg gccaagtaga ctcagctgca atggagggtg ctgaatgaac gagttggttg
3023581 ataccaccga gatgtacctg cggaccatct acgacctcga ggaagagggc gtgacgccac
3023641 tgcgtgcccg gatcgccgag cggctcgacc agagcgggcc gacggtcagc cagaccgtgt
3023701 cccggatgga gcgcgatggg ctacttcggg tggctggcga tcgccacctg gagctcaccg
3023761 aaaagggccg cgcgctggcc atcgccgtga tgcgcaagca ccgcctcgcc gaacggctcc
3023821 tcgtcgatgt catcgggttg ccgtgggaag aagttcacgc cgaggcatgc cggtgggagc
3023881 acgtgatgag cgaggacgtc gagcgacggc tggtcaaggt gctcaacaac ccgaccacgt
3023941 ccccgttcgg caacccgatc ccgggcctgg tggaacttgg cgtgggcccg gaaccgggcg
3024001 ccgacgacgc caacctggtc cggttgaccg agttgccggc cggctcgccg gtcgcagtcg
3024061 tcgtccgcca gcttaccgag cacgttcagg gcgacatcga cctgatcacg cggctaaaag
3024121 acgccggcgt ggtgcccaac gcacgagtaa ccgtcgaaac caccccaggc ggcggcgtga
3024181 ccatcgtcat cccgggccat gagaacgtca ccctgccaca cgagatggcc cacgcggtca
3024241 aggtcgagaa agtctgagct aacccgcacc taccctgcgc gttgaccgaa cgcacgtcga
3024301 ggcggcagtc gtattccgag ttgttcagcc cgttggtagc cggtgaccgc gatgtcacgg
3024361 atgtgctcag gtcgcagacc agactgcagt gccgtgtcca gcatgcccgc catccgatgg
3024421 cccggctcac agcacagcgc agcctgcagc gaaacaccgg ccagcggccc gtcaccgcgg
3024481 gcataggcgc tgaacgcgag caacaccagg gcctccaccc gccacggttc gggcagcacc
3024541 cgcgccagta acgcccacaa tgactcggcc gcaccagcat tctcgccgac ggcaagggca
3024601 tacagcatgt cgcggacccg cgcgtcgccc agtgcgcaac ccagccgcgc cagctccgtg
3024661 tcggacaagg actgaccgtc tgcgacccgg gccgcggcgg ccagcgcatt ttccacatcc
3024721 tggcggctgc agccgaccga atcagcacgg tgtgcgatct ctcggtcagc cgcttggtgt
3024781 cctagcgcaa cggcaagctc ggcggagcgc acagggtcgt ccacggcgat gacggcctgc
3024841 aggtcggagc gccgcgggta gagctgcctg ccgtccagca ccgccgccat cgccaacggc
3024901 gacgccgacg gatcgtcgat aacgccgctg cagccgcagc cgtccacaca atgccagcgc
3024961 ccgccagcgg ctacccggtc taccacgtgc gctgcccata gcacgatgtc gcgctgcgac
3025021 aacgccgccg cgagcgccgc gcacagctgc cggtactcct cattgcatcg cggacactgg
3025081 gctccgttcg cgtcaacgat caccgcgatc gcggccgccg ggttcgccgc ggcgacaagt
3025141 tctgcgagat ggccaacccg atcggcgagt tcatcacaga ggtcggcgcg catcaccgac
3025201 cctagttccc ccgctgccaa cgacaccaga accagcgatt tttccggcac gaagccgagg
3025261 atggccggta gcgcggcgat cagtgttgca gggcggttga gttcaaattg tcctcgatac
3025321 ttcgtcatga atgccacgct gactaccggc accgtcagcc ggtgcccacg tcacgcgatc
3025381 gagctgcctt cctgtggacg aaggcgtaac tgtgcgttct actgtcattt catggggtcg
3025441 atgcgtgaat acgacatcgt ggtgatcggg tcaggcccgg gcggacagaa agccgccatc
3025501 gcctcggcga agctgggcaa gtccgtggcc atcgtcgaac gcggccgaat gctcggcggc
3025561 gtctgcgtca acacaggcac gatcccatcc aaaacgttgc gtgaggctgt gctctacctc
3025621 accggcatga accaacgcga gctgtacggc gcaagctacc gcgtgaagga ccggatcacc
3025681 ccggccgacc tgttggcgcg gacccagcac gtgatcggca aggaagtcga cgtggtgcgc
3025741 aaccagctga tgcgtaaccg cgtcgatctg atcgtgggcc atggccggtt catcgacccg
3025801 cacaccatcc tcgtggagga ccaggcccgc agggaaaaga ccaccgtcac cggcgactac
3025861 atcatcatcg ccactggcac caggccggca cggccatccg gagtcgaatt tgacgaagaa
3025921 cgggtgctcg actccgacgg gatcctcgat ctcaaatcgc tgccatcctc gatggtcgtg
3025981 gtcggtgccg gcgtgatcgg catcgaatac gcctccatgt tcgctgcgtt gggcaccaaa
3026041 gtcaccgtcg tggagaagcg ggacaacatg ctggacttct gcgaccccga ggtcgtcgag
3026101 gcgctgaaat tccacctgcg cgacctggcg gtgacattcc ggttcggcga ggaagtgacc
3026161 gcggtcgatg tcggctctgc gggcaccgtg accaccctgg ccagcggcaa acagattcca
3026221 gccgagaccg taatgtactc ggcgggacgt cagggacaaa ccgaccacct cgacctgcac
3026281 aacgccggac tcgaggtgca gggccgcggg cggatcttcg tagacgaccg tttccagacc
3026341 aaggtagacc acatctacgc cgtcggcgac gtcattggct tccccgcctt ggccgcgacg
3026401 tcgatggagc aggggcggct ggccgcctac cacgccttcg gcgaaccaac cgacggaatc
3026461 accgaacttc agccgatcgg tatttattcg attcccgagg tgtcctacgt cggcgccacc
3026521 gaggtggaac tgaccaagag ctccatccca tacgaggtgg gagtggcccg ctaccgggag
3026581 ctggcccgcg gccaaatcgc cggcgactcc tacggcatgc tcaagctgct ggtttccacc
3026641 gaggatctca agctgctcgg cgtgcatatc ttcggcacca gcgccaccga gatggtgcac
3026701 atcgggcagg ccgtgatggg atgcgggggc agcgtcgagt acctggtcga cgcggtgttc
3026761 aactacccga ccttctcgga ggcctacaag aacgccgcac tggacgtgat gaacaagatg
3026821 cgcgcactca accagttccg ccgctgaggg tgccgagcgg atgtgaatcc gtctcggcgc
3026881 ccaagtaggc ttgccagcaa attcgccgcc gcccacgaac ggtcggcgtc gaacgtggcc
3026941 ccgcgctttt ggcgttgtgc agcacagcgg cagccagggt tggctgttca atcattgctg
3027001 tccgctgatt tgagggacac tggttacggc acctcggcga caaccccgag aggaggcaac
3027061 acccatggct cgcgatcaag gcgcagacga agcgcgagaa tatgagccgg ggcaacccgg
3027121 catgtacgag cttgagttcc cggcgcctca gctgtcgtcg tccgacggcc gtggtccggt
3027181 gttggtgcac gctttggaag gtttctccga cgccggccat gcgatccggc tggccgccgc
3027241 ccacctcaag gcggccctgg acacagagct ggtcgcgtcc ttcgcgatcg atgaactact
3027301 ggactaccgc tcgcggcggc cattaatgac tttcaagacc gatcatttca cccactccga
3027361 tgatcctgag ctaagcctgt atgcgctgcg cgacagcatc ggcaccccat ttctgctgct
3027421 ggcgggtttg gagccggacc tgaagtggga gcggttcatc accgccgtcc gattgctggc
3027481 cgagcgcctg ggtgtacggc agaccatcgg cctgggcacc gtcccgatgg ccgttccgca
3027541 cacacgaccg atcacgatga ccgctcattc caacaaccgg gagctgatct ccgattttca
3027601 accgtcgatc tccgaaatcc aggtcccggg tagcgcttcc aacctactgg aataccggat
3027661 ggcccagcac ggtcatgagg tcgtcgggtt caccgtgcac gtcccgcact atctcacgca
3027721 gaccgactat cccgcggccg cccaagcgct gctcgaacaa gtggccaaga ccggttctct
3027781 gcagctgccg ctggccgtgc tagccgaagc agccgcagag gtccaggcca agatcgacga
3027841 gcaggtccag gcaagcgccg aagtggctca agtggtggcg gcccttgagc gccagtacga
3027901 tgccttcatc gacgctcagg agaacaggtc gttgctaacg cgcgacgaag atctgccgag
3027961 cggcgacgag ctcggtgccg agtttgagcg gttcctggct cagcaggccg agaagaagtc
3028021 cgacgacgac ccgacctaac gccgcgaaag cggcccacaa aacggcccca gtcggcccga
3028081 caacaagatt ggcgaggatg accgagcgga agcgaaatct tcggccagtg cgcgacgtgg
3028141 caccgcctac gctgcagttc cgcaccgtcc acggttatcg gcgggcattc cggatcgccg
3028201 gttccgggcc ggcgattctg cttatccacg ggataggtga caattccacc acctggaatg
3028261 gggtgcacgc caagctcgcc caacgattca ccgtcatcgc tccggatcta ctgggccacg
3028321 ggcaatccga caagccgcgt gccgactatt cggttgcggc ttacgccaac ggcatgcggg
3028381 acctcctcag cgtgctcgac atcgagcggg tgaccatcgt gggccattcg ctcggcggcg
3028441 gggtagcaat gcaattcgcc taccagttcc ctcagctagt cgaccgactg atcctggtca
3028501 gcgcgggcgg tgtcaccaag gacgtcaaca tcgtcttccg gttggcctcg ttgcccatgg
3028561 gcagcgaggc tatggccttg ctacggttgc cgctggtgct gccggcagtg caaatcgccg
3028621 ggcggatcgt gggtaaggcc atcggtacca ccagcttggg gcacgacctg cccaatgtgc
3028681 tgcgcatttt ggacgacctg ccagagccga cggcttctgc ggcgttcggc cgcaccctgc
3028741 gggcagtggt ggactggcgg gggcagatgg tcaccatgct ggaccgatgc tatttgaccg
3028801 aagccatccc ggtacagatc atctggggca caaaggatgt cgtgctgcca gtccgtcacg
3028861 ctcacatggc gcatgccgcc atgccgggct cgcaattgga gattttcgag ggctcgggac
3028921 atttcccgtt tcacgacgac cctgcgcgct tcatcgacat cgtcgaacgc ttcatggaca
3028981 ccactgagcc cgccgaatac gaccaggccg cgctgcgcgc gttgcttcgc cggggtggcg
3029041 gcgaagcaac cgtcaccggc tcggcagaca cccgtgttgc agtactgaac gccatcgggt
3029101 ccaacgaacg cagcgctacc tgatcaccac cgggtctgtt agggctcttc cccaggtcgt
3029161 acagtcgggc catggccatt gaggtttcgg tgttgcgggt tttcaccgat tcagacggga
3029221 atttcggtaa tccgctgggg gtgatcaacg ccagcaaggt cgaacaccgc gacaggcagc
3029281 agctggcagc ccaatcgggc tacagcgaaa ccatattcgt cgatcttccc agccccggct
3029341 caaccaccgc acacgccacc atccatactc cccgcaccga aattccgttc gccggacacc
3029401 cgaccgtggg agcgtcctgg tggctgcgcg agagggggac gccaattaac acgctgcagg
3029461 tgccggccgg catcgtccag gtgagctacc acggtgatct caccgccatc agcgcccgct
3029521 cggaatgggc acccgagttc gccatccacg acctggattc acttgatgcg cttgccgccg
3029581 ccgaccccgc cgactttccg gacgacatcg cgcactacct ctggacctgg accgaccgct
3029641 ccgctggctc gctgcgcgcc cgcatgtttg ccgccaactt gggcgtcacc gaagacgaag
3029701 cgaccggtgc cgcggccatc cggattaccg attacctcag ccgtgacctc accatcaccc
3029761 agggcaaagg atcgttgatc cacaccacct ggagtcccga gggctgggtt cgggtagccg
3029821 gccgagttgt cagcgacggt gtggcacaac tcgactgacg tagagctcag cgctgccgat
3029881 gcaacacggc ggcaaggtga tcctgcaggg gttgcccgac cgcgcgcatc tgcaacgagt
3029941 acgaaagctc gtcgccgtcg atgcggtagg aacggtcaag ggcggtcacc tcttttgcgg
3030001 tcggggccaa tccgatcgac ccatccgcgc gtgtggacaa ttcgagttcg atgacgtcac
3030061 cggtcaccga ataggttcca acctcaattt cggtgatgcc gcttggatgg gcgagaacga
3030121 gttcaacgca gcccggtcgg caaacgcgga gataccccgt ctcggaatgc agcggcttcc
3030181 cgtcagctac cgccctggtc tgctgtgtgt acgtcagaaa cggtttaccc acatgggcga
3030241 atacgacttc ctcgaggtat tcgaacggcc ggatggtggg gtacttgccc gcaccgcgac
3030301 ccgcccaact ccccaggagg ggtgacagcg cctgcagggc aggggccaga tctcgggtca
3030361 tcgcccgctt gcgggggaca ggcatgcggg aagcctagcg ccgcgagatc ggtcagctgt
3030421 gggctgatag gttgcggtgc gcgcgaagcg cctcaatctc gcgcgcgaaa tcgtccgcgg
3030481 aagaaaacga ccggtagacc gacgcgaacc gtaggtaggc cacctcgtca agctcgcgca
3030541 acgggcccag gatagccagg ccgacatcgt gactcggaat ctccggcgac cccgcggcac
3030601 gcaccgaatc ctcgacttgc tgagccagca ggttcaacgc atcgtcgtcg acctggcgtc
3030661 cctggcacgc ccggcgcaca ccgctgatca ccttttccct gctgaagggt tcggtaacgc
3030721 cactgcgctt gactacggcc agcaccgcgg tctctacggt ggtgaatcgt cgtccacatt
3030781 cggggcacga cctccggcgc cggatcgcct ggccttcatc ggtttcccgg gaatcgatca
3030841 cccgcgaatc gggatgccgg cagaacgggc aatgcatggc cgctcctttg ccgtcttgac
3030901 atccgggtat cacagacgac tccgagcgta cctgtgtgct cccgcgggta gccactgcag
3030961 tcacgactga tgcgcatatt gcgtcgcggt cacccagtaa cgttgacaca gaacggtttt
3031021 cgcggacacc gggatggcct cagccaaccg gagcgatcag cgtctgaccc acggccaatg
3031081 ccggtgtctg caggccgttg agttcacgga tgcggtcggc aacctggcgg gtcggagcgt
3031141 tcggcgccac ccggaccgcc acgtcataca gggactcccc cgtttccacc cgtaccacgg
3031201 caagcctgtc gggcacccga ccggtcgaat cggccgaccc gtcggccgaa ccgccggtga
3031261 tcatctgccc gaactgcgcc accaaaccaa gccagagagt aatcgccgcg gcaagcagag
3031321 ccagccccac cgtcgtggcc ggcgggacgg gcctgctgcc atgcccagtc ctcgacatcc
3031381 cgaccccggt gcggtggtag cgcagcggcg caccccccgg cctcgatcgg ccgggcctgc
3031441 gcgattgcgc cggctcagcg cggcgccagc gaggtccatc gagcgggccc cgcagattga
3031501 gcggatcggg ggtatgcggt ggccggaccg gtgtcatgtt cgctcctcca actcagacgg
3031561 taatcgctcg cgtgttcgac actgtagtca ctcatgtgtt cgatatccga acatttgatc
3031621 gaagcgtgtc gcacgcgcaa aacggtagac cacaccaccg acacgtttcg gttggagccg
3031681 gacttccggc gcgaaggccc agccactcct cgtgccctcc cgcgaccgga acacgcctgt
3031741 cgaacacatg tttgattctt ggtgcgaatg cgactacatt cattgccatg aacgacagca
3031801 acgacacctc ggttgccggc ggagccgctg gtgcggacag ccgggtgctg tccgcagatt
3031861 cggcgctgac cgagcggcaa cgcactattc tcgacgtcat ccgcgcgtcg gtcactagcc
3031921 gcggatatcc gccgagcatc cgggaaatcg gcgacgccgt tggtctgacg tcgacgtctt
3031981 cggtggcgca ccagctgcgc accctggagc gcaagggcta cctacgccgt gacccgaacc
3032041 gcccccgcgc cgtcaatgtg cgcggtgccg acgacgccgc cctaccgccg gtgaccgaag
3032101 tggccggctc ggacgcctta ccggaaccca cctttgtccc tgtcctggga cgtatcgcgg
3032161 ccggcggccc gatccttgcc gaggaagccg ttgaagacgt cttcccgctg ccgcgtgagc
3032221 tggttggcga gggcaccctg ttcctgctca aggtgatcgg tgactcgatg gtcgaagccg
3032281 cgatctgcga cggtgactgg gtggtggtgc gacagcagaa cgtcgccgac aacggcgaca
3032341 tcgttgcggc catgatcgac ggtgaggcca ccgtcaagac gttcaaacgc gccggcggtc
3032401 aggtgtggtt gatgccgcac aacccggcct tcgatcccat cccgggcaac gacgcgacgg
3032461 tgctgggcaa ggtcgtcacg gtgatccgca aggtctgatg ctgatccgcg tgcaggctgt
3032521 caatccgccc taatgaagcc gttgacttgt gccacttctt cactggcgaa ccagagttcg
3032581 gccagcgtgt cgtggtatag cgcactgccg ggtgggtaat acaggccgaa gctcacactg
3032641 gctttgacgg gatagccgtt cggcatctgg tatgggtcct cgagcggcag atgaattgcc
3032701 gggcgcacgc ccgcactcgg cggttccggc ggttctgcgg ccgcgtgccg cccgcctctg
3032761 tcttcagctg cggatacagc cgccgccggc aacccagtgt cagcaagatc ggcagcgtgg
3032821 acatcgggcg gcaccgcttc aggcgccact gcttccggaa caaaggcttg cggaacgaaa
3032881 gtctccggaa ccactcgctc aggaacaatg agatcgggac cgacttcgga aaggtcggcc
3032941 tgcgacacaa cgggtgtcgg cgtggtgtcc accgcatcgg tgtcttcctc ctcgaccccg
3033001 acgttgctgg ggccggacag caagtcgctg ccgtagccct cctcacccgg aagatgctcg
3033061 gcatcaccga cagccgcccc ggcgccgcgc ggccagctga cccgcggtgt ggacccggcg
3033121 tccggcgcca caggttccgg cgggaactgg tcgccgaaac cgaaatgctc tgaaccgaag
3033181 tcctcgtcgg gcggccagtc tccatcagcg gcggtaccgt actcgacatc cccagcgcgg
3033241 tcatcgtcgt aagcagcggc gtcgtaccca cgtcgacgcc gacgcaatcc gaacaccacc
3033301 aacgccacca tcacgaccag gagcaccccc agggcggcgg cccctaacca ccaccaatgc
3033361 caggtgaact tcttgccggg tgggggcatc gccgaagtac ttggctggtt ctgccctgac
3033421 acctgcagac cggacagcaa gggcgctagg ttagcgggat ccgtagtgaa tgtgtttttt
3033481 gcacggttcc acgaaatcat gccgccggtg aatttctgtg agacaacatc gccgtcgacg
3033541 gtctggtcgc cgaccggggc gccgagcttg ccgttggggc cgcgcagctt gtcccacgcg
3033601 gccaccatgg ctccgcgcac gacgaacgcg ccgtggtccg gagtccagaa aatcaccggc
3033661 ttgtcggccg cggagaacct gacgatccgg ctggagggcc caaaaccacc atcagtttcg
3033721 ttggcgatgg ggaaacccaa gtcgctgctg accggtccgc ccagcgactc gtacttcgcc
3033781 aggatttcac cctcgacggc gtttgcaccg gttgccgggc tgaagaagac cttgccaccg
3033841 acgaagtcct gggcgatacc gtctccgccg atcgggtact gcccaccctt cttggcgccc
3033901 agcggacctg cggcaccacc tgctgcgcgc caggccatgt tgatcgccgc ggaaggatcg
3033961 atcgctacct gcaaaccctt cagctgctcg gccagcaccg ccggaacggt ggtgaactcc
3034021 ttggttgccc ggttccagga gacttcacca ccgctgaact tctgggcggt gacctcgccg
3034081 tcgtaggttt catccccgac cggggcaccc agcacgccac ccgagctgcc gagcttgtcc
3034141 cacgcggcat tcagcgcgcc gcgcacgacg aacgcaccgt gttcaggcgt ccagaaaatc
3034201 accgggttgt cggccgcgga gaacgtgctc acgcgactgt cgggtccggc aaggccgggc
3034261 acctcgttga tggtcgggaa tcccagatcg ctgtcggctg caccgcccag cgactcgtat
3034321 ttgtccagga gcgggccgta gaggtatttg gcaccggtgg ccggggtgaa aaacatcttg
3034381 ccgccggcga agtccagggc gaacccgtcg cctatcgggt aaacgtcacc tttccggaca
3034441 ccaagtgttg aagtgtcacc acccgccttc tcccacgcgg ccatcatggc gtcctcggca
3034501 tcgcccatcg gcgaagccgc caccgtgggc gccagcaaca cggcggtcac cgccgtggcc
3034561 gccaagccga gcagcgtacg cccgatcagc gtgctcaatt gacctctctg cccgttcacc
3034621 aagcctccca gccgatgccc tgcctagccc gccagccggt ggatctccca ccgtgggccg
3034681 gtccccgctg cggtccgtat tgtccccggg ctcgcataac attgctccag cgaacgacga
3034741 ttgcgaagtc caatcgcaaa tattacgaaa acggataccc agccgatgtc aaattgatgc
3034801 cggggcacgc tgctgtggtg agcaaccggg ctgcagcccg ggccgggttt gcgttaccgt
3034861 gccggaaacg acaaccggac tgatgcggtg agaggaatcc cggctgacat gggtgcttcc
3034921 ggcctggtct ggaccctcac catcgtcctg atcgccggct tgatgttggt cgactacgtc
3034981 ctccacgtac gcaagaccca tgtaccgacg ttacgtcagg ccgtcatcca gtcggcgacc
3035041 ttcgtgggga tagcgatcct gttcggcatc gcagtggtgg tgttcggcgg ctcagagctg
3035101 gcggtcgaat atttcgcctg ctacctgacc gacgaagccc tgtcggtcga caacctgttc
3035161 gtatttctgg tcatcatcag cagcttcggg gtgcctcgtc tcgcgcaaca aaaggtgctg
3035221 ttgttcggta tcgcgtttgc gctcgtcacg cgcaccggat tcatcttcgt cggcgccgcg
3035281 ctcatcgaga acttcaactc ggccttttac ctgttcggcc tggtcctact ggtcatggcg
3035341 ggcaacctcg ccagacccac cgggctagaa agccgcgacg ccgaaacgct caagaggtcc
3035401 gtcattatcc ggctagccga ccgcttcttg cggacctcac aggactacaa cggagaccgg
3035461 ttgttcacgg tctcgaacaa caagcgaatg atgaccccgt tgttgctggt catgatcgcc
3035521 gtgggtggca ctgacatact atttgcgttc gattcgattc cagcactttt cggcctgacc
3035581 caaaacgtct atctggtgtt cgccgccacc gcgttctcgc tgttgggcct gcgccagctg
3035641 tacttcttga tcgacggcct gctggatcgg ctagtctatc tgtcttacgg gttggccgtg
3035701 attcttggct tcatcggcgt caaactgatg ctggaagcat tgcacgacaa caagattccg
3035761 ttcatcaacg gcggcaagcc ggtcccgacc gtggaggtga gcaccaccca gtcgttgacg
3035821 gtgatcatca tcgtcctgct gatcacgacc gcggcgtcgt tctggtcggc gcgcggacgg
3035881 gcgcagaacg ccatggcgag ggcccggcgg tatgcaaccg catacctcga cctgcactat
3035941 gagaccgagt cggccgaacg cgacaagatc tttaccgcac tgctggccgc tgaacgccag
3036001 atcaacactc tcccaacgaa ataccgcatg cagcccggac aggacgacga cctgatgacg
3036061 ctgctgtgca gggcccatgc cgcgcgcgac gcgcacatgt gagcccgcgc tagctgaggg
3036121 ctagctgcgc ctaaacaccc aagccacgac cgatgatctc tttcatgatc tcggtcgtgc
3036181 caccgtaaat cgtctgtacc cgcgaatcga gataggcccg ggcgactggg tattcgcgca
3036241 tgtagccgta cccaccgtgc agctgcagac agcggtcgtt cagatacacc tgcttctcgg
3036301 tggcatacca cttggccatg gcggcctgct ctgccgtcaa cttccccgcc aggtgcagct
3036361 taatgaattc gtcgaccatg atgcgcacca cagtggcctc ggttgccagc tcggccagca
3036421 agaatcggct gttctggaag ctaccgatcg acctgccgaa cgccttgcgc tccttggcgt
3036481 actgcagtgt ctgctccagc acggattcca tccccgcggc cgccatgatg gcgatcgaga
3036541 tccgttcttg cggcaggttc tgcatcaagt agatgaaccc catcccctcc tggccgagca
3036601 ggttttcggc tggaaccgcc acgtcggtga aggacagctc ggcggtgtcc tgggcgtcca
3036661 acccgatctt gtccagctgg cggccgcgtt cgaatccagc catgccgcgt tcgacgacca
3036721 acaaactgaa cccttgcgca cccttttcgg gatccgtctg cgccaccacg atcactaggt
3036781 ctgaattgat cccgttggtg atgaacgtct ttgacccgtt tagcacgtaa tgatcaccgt
3036841 gtttgacggc acgggtggtg ataccttgca ggtcactacc ggttccgggc tcggtcatcg
3036901 cgatcgcggt gatcaattcc ccggtgcaga agttgggaaa ccagcgccgc ttctgctctt
3036961 cggtggccag cgccagcaag tacggcgcca cgatgtcgtt gtgcaggcca aaaccgatcc
3037021 cgctgtaccg tccggcgcag gtttcctcgg tgatgaccgt gttgtaccgg aagtccgcgt
3037081 tacccccacc gccatactcc tcgggcaccg ccatgcccag aaatccctgc ttgccggcct
3037141 ccagccacac gccgcggtcg acgatcttgg tcttttccca ttcatcgtga tagggcgcga
3037201 cgtggcgatc gaggaacgcc cggtaagact cgcgaaacaa ctcatgttcg ggttcgaaaa
3037261 gtgtgcgctg gtacttggtg gcactgccca tggatgccct ccggggaaga aaattctggt
3037321 gcccaacaat accaaccggg cggttggtcg gcaggtagcc ggggcgcgcc agccgctgcg
3037381 agcgtaacgc cacggcgagc ttgcgtgcac cgaattcgcc gtggcgttac gctcgcggcg
3037441 caaactcgcg caaggtggca gccagcgcct ccgggacacg ggccttgatc cgggtgccct
3037501 cgggcttgtg ctccgcctgc tgtatccgcc catcggcgtg cacacgggcc accaggtcgc
3037561 cgcggtcgta cgggatcacc acgtcgacgg cggtgtcggc gggcacaacc agctcggcca
3037621 tccgccgtcg gagcgcatcg ataccgtcgc cggtgcgggc ggaaacgaac accgcgccgg
3037681 gcagcccgtg ccgcagcttg gccagcatca ggtcgctagc gacgtcaacc ttgttcacta
3037741 ccagcagctc gggcggcgga tcgccgtcat ggtcggcgat cacctcggag atcacctgac
3037801 ggaccgcgtc gatctgggct agcgggtggc cgtcggatcc gtccacgacg tggaccaata
3037861 gatcggcgtg cacgacctcc tccagcgtgg agcgaaacgc ctcgaccaac tgggtgggca
3037921 ggtgccgcac aaagccgacg gtgtcggtga gcacgactgg cctaccgtca ccgaactccg
3037981 cgcgcctggt ggtgggttcc agggtggcaa acagcgcgtc ctgtaccagc accccggccc
3038041 cggtcagcgc gttgagcagg ctggacttac ccgcgttggt gtagccgaca atcgcgatcg
3038101 acggcacgtc actgtgccgg cgacggctgc gctgggtgtc gcggacctgt ttcatggccc
3038161 tgatgtcgcg ccgtaacttg gccatccgct cgcggatgcg gcgtcggtca gtctcgatct
3038221 tggtctcacc gggaccgcgc agacccaccc cgccaccact gccaccggcg cgaccgcccg
3038281 cctgccgtga catcgactca ccccagccgc gcagccgcgg cagcatgtac tccatctgag
3038341 ccagcgacac ctgggctttg ccctccctgc tggtggcatg ctgggcaaag atgtcgagga
3038401 tcagcgcggt gcggtcaata accttaacct gcacagcctt ttccaaggcg gtcaactgcg
3038461 ccggcgacag ttcgccgtcg cagatgacgg tgtcggcgcc ggtcgccacg atcacttcgc
3038521 ggagttcggc cgctttgccc gagccgatgt aggtcgacgg gtcgggcttg tcgcgacgct
3038581 ggatgagtcc ttcgagcacc tgggagccgg cggtttcggc caatgccgcc agctcggcca
3038641 ggcttgcccg gttgtcagcc gcgctgccct cggtccacac tcccaccaac accacccgct
3038701 ccaggcgcag ctggcggtac tccacctcgg agacgtcggc aagctcggtc gacaacccgg
3038761 caacccggcg cagcgccgat ctgtcctcga gtgcgagctc accgaggctc ggtgtgaagt
3038821 ccgaaaggcc cgtctggggc ggatctggat atgtcatagc cagtacccga tggtggcacg
3038881 tggcagctgg ccgcgcatct gaatttgccg gcataagccg ctgcctggga tcaccccatc
3038941 gcgttccacc aatcgtcagc gagatctccg cgggccacca acactgacgg cccacgcagg
3039001 aagctggtgg catcggtgac ggtaaccacg acctctccgc ccggcacgtg cacggtgagc
3039061 gttccggtcg gcgagcccac cgccgccaac gcggcgaccg cggccgcaac cgtcccggtg
3039121 ccacacgagc gggtttcccc cacgccgcgt tcgtgaaccc gcatccagac cgccccgtcg
3039181 accggcgcgg tgagtacctc gacattgacc ccgtcgggga actgcgcacc atcgaaactc
3039241 accggcgcac ccacgtccaa tgccgccagg ccgtcgacgg tcagctggga atccacgcac
3039301 gccagatgcg ggttacccac atcgacggcc aggccgtgaa accgcctgcc accaacaaca
3039361 gcctcccctg cgcccaatct gttggccttg cccatgtcga cggagacgtc ggcgtaggcc
3039421 gcctcgacgt ggtggcaggt gactggtcgc ggtccggcca gtgaccctac gacgaactcg
3039481 tcgcgaacct ccaggccact ggcacgcaag tagtgcgcga acactcgcac accgttgccg
3039541 cacatctggg ctgccgaccc gtcggcgttg cggtaatcca tgtaccagtc ggtcacgcgg
3039601 acaccctcgg gcaggctgtc cagcactcct accgcctggg cggctccggc ggtcgtaacc
3039661 cgcaacaccc cgtcggcgcc cagccccttc cgccggtcgc acaatgccgc cacccgggca
3039721 gcggtgagca ccaactcggc gtcgacgtca ggcagcaaca cgaagtcgtt ctgggtaccg
3039781 tggcccttcg cgaagatcat ctgcgccact cctcaatcac cagatcaggt tacgtgccgc
3039841 cataaccgca cggcgtcgtc gaccagtcgt gcgcggtccg gtgagctggc cacaccggcg
3039901 tcgagccagt gcacccggtg gtctcggcga aaccaggacc gctgccgtcg cacgtagcgg
3039961 cgggtgccca ggtacgtctg ctcccgcgcg gcgcgcatca tgtcagctcc agcaccggcg
3040021 tccagagcgg ctattacctg cgcgtagccc agcgcgcgtg acgcggtgac cccctcgcgc
3040081 agaccattgc ggagcagagt gcgtacctct tcaaccaggc cctgatcaaa catcaggtcg
3040141 gtgcgacggg ccaaccgctc gtcgagaatc gttgtctgac agtccaaccc gacgataacc
3040201 gtgtcccacc gcggcgcacc gatgcgtggc gcggacgcgg caaatggctg cccggtgagt
3040261 tcgaccacct cgagcgcccg caccgtgcgc cgggcatctg tgggcaggat tgccgcggct
3040321 gcagccgggt ctcggcgggc taactcggcg tgcagccgat ccaccccgac ctcggccaga
3040381 cgccgctccc atctcgcgcg tactgaagga tcggttgcgg gaaacgacca gtcgtcgagc
3040441 agggattgga catacagcat cgagccgccc accacgaccg gcaccgctcc ccgggctgcg
3040501 atcgcctcga tgtccgccgc ggcggcccgc tggtagcgcg ccacggtcgc ggtttcggtg
3040561 acatccagga catcgagttg atgatgcggg atgccacggc gctcgctgac gggcagcttc
3040621 gccgtcccga tgtccatgcc gcgatacagc tgcatcgcgt cggcgttcac gatctccacg
3040681 ctcaccctgg cgccgagccg cgcggcgacg tcgagcgcca actgggactt gccggcgccc
3040741 gtcggtccga taatcgccaa cggtctcacg gctgccagac accggcgaaa taccccacgc
3040801 cgtgtggcgc tcctcggtag aactccttgg ccgatcgcgg tcctggctcg gccaggccgg
3040861 ccagcacctg aaatgccacc cgcccaagca cctgtgcggg cagccgggtc aagacggcga
3040921 ggtcgccgct ggccaacgcg tcgtcgagag cccgctgcat accggcgccg tcggggtcat
3040981 agccgccggg agcgcggggc gtcagggtgt tcaggccgtc ggcgacgact agtaccccga
3041041 tcggatcggg ctcccggtcg atgtcggctc gcagttgcct gccacgtgcc accgcggcat
3041101 cggaaccgtg gtcgctggca tagacgtgga cctgtgccct ggcctcaggc cgggcctggc
3041161 cccgtaccca ggcggtaagt agcgcacaca ggggtaattc caccggaacg gcaactccgt
3041221 caccgtcctg cggcgcgagc ccgactcgca cgtcggcgcc gaagcccgca aaggtgccga
3041281 cgtcggtggg gcgcacgacg tcgtcggcgc gcccggttcc gacagcaatc cagcttttcg
3041341 gcaacaagga ggccgccgcg atcaccgcgg cccccaaatc ggccagctcg gcagcggcgg
3041401 ctccggccag ttcgggaacc aacaccggcg cggacggaac gatcccgatg gcgctcaaca
3041461 caacacaaag ctaacgcctt ggcgggcgga ttcggcctcg tggagcaacg gctgcaaaga
3041521 gaccgtgctg agaggccgac actgtcccgc gctcattggc cagagacggt caacgaaccg
3041581 caagctggcc cgcggccccc aattcgccgg cggaaaccgt catcatcgcg acctcgtcac
3041641 gggccaaggc tacggtcgcg acaaccacca ccactaccgc tgccaccagc gcgaccaggg
3041701 ccacccggcc ggtgtgcagc acctcatcga gcacggtgat ccccagcacc gaagcgatca
3041761 ccggcctcgc cacggtgatc gtcggcaacg aggcggttag cgcgcccacc cgcaacgacg
3041821 actgctgaag catcagcccg atcggtagaa ccaggatcca ggcatacaac gcgggggtcc
3041881 ggatcagtgt cgcgaacccc tcgccgagct ccgtcacgac ccctttggtc agcacggtga
3041941 ataccgccaa cgttgccgac gacgccaccg ccagcagcac cgcggacagc gaacccgagg
3042001 caatccgtgc accaaccaca caaagcacca ccgccggaac aaccacgaca gcaaccaccg
3042061 cccaggtcga gaagggggcc cgagtagtgc cggccgccgg gttgcccgac atgacgatga
3042121 cggccaccgc gccggccagc aataccgccc acatccactc cctgggagta cagcggtgat
3042181 gagtcaaccg agcatcgatc agcagcgcga acaacagtgc ggtggcctgc agcgactgca
3042241 ccaacaccac cgaacccatc gtcagcgcaa tggcctgcag ggtgaaactg gcgactgcgg
3042301 ccaggctgcc cagccaccac agagcgtgac gcaaagagag gtggaacaac gtgaaatggc
3042361 cgacatattc ttcagcggtg acctgtcgcg cggaccgctg aagtgtcaca tacccgatcc
3042421 cggccagcaa cgcggcgccc agcgccagaa tggtcgcgaa ttcgacgctg gccataggtg
3042481 acctcccacc gacattcggc ccggaagctg actgatacat ctcgatttaa gcagttgttc
3042541 aatgatgatg aactggcgcc agacaaatat cacaacaaaa cgttgcgcgc agacgcgtgc
3042601 ttcgtcatcg gcttcggaat tctgcggcat attcgctgcg ccgggattga tgaggaattg
3042661 ccatcatggt ggctcggccc caagtgcggt cggcgggtcg gccgtgcaat tgaccgttgc
3042721 ttacggccct cagcgcttcc acgggaggtg cgcgagtaac agctcggttc ggccccttac
3042781 taccggcggc agctggaccc cgacctcgat cagctctacg gatggcggaa aagcacaggg
3042841 ccatgacacc cacgatcggc aaatatcgcg acgaacagtc tgtcaagcgg cctcaatact
3042901 tgcttcaata ctgttggaaa cggtggcagg accgggtgag ggcatcgggc cgaccacatc
3042961 ggtgccgctt cgcgcggcag atgcgcggca tacgcgcgaa gggttgcaag gtaggtgaca
3043021 agcgcatgac ggccgacgag ccccgcagcg acgattcgtc cgggtcggcc ccccaaccgg
3043081 ctgccacgcc ggtgccccgc ccgggaccgc gtcccggccc ccggccggtg ccgcgaccca
3043141 cctcctaccc ggtgggtgcg caccctccca gcgacccgca ccgtttcggc cgtatcgacg
3043201 acgacggcac ggtgtggctg gtcagtgcga gcggcgagcg tatcgtcggc tcctggcagg
3043261 ccggcgatcc cgaagccgcg tttgcccatt tcggcaggcg attcgatgac ctgagcaccg
3043321 aaatcatgct gatggacgag cggttggcgt ccggcaccgg cgacgcacgc aagatcaaag
3043381 cccatgcgat cgcgctggcc gaaacgttgc cgacggcatg cgtgctgggc gatgtcgacg
3043441 cgctggcaga ccggttgaca agcattcgtg atcgcgcgga ggtcatcgct gccgccgacc
3043501 gctccagacg cgaggaacat cgagccgccc agaccgcccg taaagaggcg ctggccgccg
3043561 aagccgagga gctggccgcc aacgcgacac aatggaaggt cgccggtgac cggctgcggg
3043621 caatcctcga tgaatggaag acgattagcg gtgtggaccg caaggtcgat gacgcgctgt
3043681 ggaagcgcta ctcgacggcc cgcgatacgt tcaaccggcg gcgagggtcc cacttcgccg
3043741 aattggaccg tgagcgatcc ggcgtccggc aaagcaagga acggctttgt gaacgggccg
3043801 aggagttgtc cgagtcgacg gactggaccg ccaccagcgc ggagttccgc aagctgctcg
3043861 ccgactggaa agcggcggga cgcgcgagca aggatgtgga cgacgccctg tggcgtcgct
3043921 tcaaggccgc gcaggactcc ttcttcacgg ctcgcaatgc cgccaccgcc gagaaggagg
3043981 ccgagttgcg agccaatgcc gacgccaagg aggcgctgct ggccgaagcg gagcggctcg
3044041 acacgacaaa ccacgaggcc gctcgagcag cgctgcggtc gatcgccgag aagtgggacg
3044101 cgatcggcaa ggtgtcgcgg gagcgggccg cggagctgga gcggcgacta cgcgcggtcg
3044161 agaaaaaggt gcgagaagcc ggcgaagcgg attggtccga cccgcaggcg cgggcccgcg
3044221 ccgagcagtt ccgcgcccgg gccgagcagt ttgaacacca ggccgagaag gcagcagcgg
3044281 ccggtcgcac caaggaagcc gacgaggcga aggcgaacgc cgaacaatgg cggcagtggg
3044341 ccgaggcagc cgccgacgcg ttgacccgac gcccctaacg gtcggtgccg cggtcgggcg
3044401 ttgtcccggc ctcggagtcc gtttgcacgt ggtccagcag cgtcttgcac tgttgttgcg
3044461 cgacgacgcg gcgacgccgc tcctcggctg cgagctgcac gatggtgcgc gaccacacca
3044521 cctgggccca gtggaatgtc aacacgatcg cggtgatcca ggcgacgatg agcccgatac
3044581 cggggccggg atgaccggcg gcgaccgtct gacgcgacca tacggccagc agcccggtac
3044641 cgctggccat cgccgaaccc gccagcgcca cccaagccag cgcccaccgc cgggtgagca
3044701 acgccagcat cgagaagcca acgccgaaca ccagcgccaa ccaggcgaat acccgcgagg
3044761 gcagcgcgac ggcggccctg ccggcgccgt ggctgctgaa caacacatcc cagccgcgca
3044821 cgcttccggt atgcggcagg ataaacgacc ccaacagcac gaacaccagg attgcgacaa
3044881 ccaaagccct cgcgcctggc tcgatttcgc gcgcaacgcg gcgttctgcc gcctcgatct
3044941 cagcgcggag ggcgtcgaga tccccggcgt cgtgttcgtg gctcatcatc tgcatcctcc
3045001 gggcttggcc gcgctgaccg gcagcccgac cccaggcatg cccaggccga cggcgcgccc
3045061 cggctgcccg gcggtgtgcg cgtcgccggc gcgggtgcgg cggtgggtca ggacgccggc
3045121 gtcggcgatg aggtggtgcg gcgccgcttc ggtgaccttc gtggtgatga cgtcgccggg
3045181 acgcacgcgc ggctggccgg cggtgaagtg caccaggcgc ccgtcgcgcg cccgcccgct
3045241 catgcgcgcc gtgacggtgt ccttgcgccc ttccccggtg gccaccagca cctcgacggc
3045301 ctgcccgacc agggcgcggt tggcttccag cgagatttgc tcctgcagcg cgatcaggcg
3045361 ttcatagcgt tcctgcacaa cggctttcgg cagctgtccg tcgagttgcg cggccggtgt
3045421 cccgggccgc ttggagtatt ggaaggtaaa tgcggccgcg aagcgggccc ggcgcaccac
3045481 gtcgagcgtg gccgcgaagt cctcttcggt ctccccgggg aaaccgacga tcagatcggt
3045541 ggtaatcgcg gcatgcggga tggccgcccg cacgcgctcg atgatgccga ggtagcgctc
3045601 ggcacgatag gaccgccgca tcgcgcgcag gatccggtcg gatccggact gtagcggcat
3045661 gtgcagcgcg gggcagacgt tgcgcgtctg cgccatcgcc tcgatgacgt cgtcggtgaa
3045721 ttcggccggg tgtggggagg tgaaccggac ccgctccagc ccgtcgatgt ctccgcaggc
3045781 ccgcagcaac tcggcgaaag ctccccgatt acggggcaat gcggggtcgg cgaacgagac
3045841 gccgtaggcg ttgacgtttt ggccgagcag ggtgacttcg agcacaccgt cgttcaccaa
3045901 ggaccgcacc tcggccagga tgtctgccgg gctgcggtcg acctccctac cccgcagcga
3045961 cgggacgatg cagaacgtgc agctgttgtt gcagcccacc gagatggaaa cccacgcggc
3046021 ataggcagat tcgcgggagc tgggcagcga cgacgggaac tgttgcagcg cctcggcgat
3046081 ttcgacctgg gcgaccttgt tgtgccgggc gcgctccagc agcgtgggca aagacccgat
3046141 gttgtgggtg ccgaagacaa cgtctaccca cggcgccctg cgcagcacgg cgtcgcggtc
3046201 tttttgcgcc aggcagccac cgaccgcgat ttgcatgtcg ggattggcgc gcttgcgcgg
3046261 ggccagatgg ctgaggttgc cgtacagcct gttgtcggcg ttctcgcgga cggcgcaggt
3046321 gttgaacacc acgacgtcgg cctcggaacc gtcggtcgcc ctccggtagc cggccgcttc
3046381 cagcagaccc gccagccgct cggagtcgtg gacgttcatc tgacagccgt aggtgcggac
3046441 ctgataggtg cgcgctggcg ctcgccgcac gggcggcccg gcgccctcgc cggtcacccc
3046501 cgcggcggca tcgtgcgcca ccatcgaagt cacggggcca tggtacggcg gctgggcggc
3046561 tcgcggccca gcggatggtg tcgcctcgtc gcagcatcgg gctagcgggg acgcgctcga
3046621 cacggtggcc gatcacggct tcgctgcaca ccggctcgaa gaagtcggcc acgcgcatga
3046681 ggtagtcgcg tcgtcaccga cactatggct cgcttgcctc taaagcatcg cttatgccac
3046741 agaccagact tgtcggagcc gctgtctagc atcggggacc gggtgctcgg cgcggacaaa
3046801 cgtcatgaag ggaatcgata atgtcggatc gctcagcgat cgaatggacg ggggcaacct
3046861 ggaacccggt caccggatgc gaccgtgtat cgccgggatg tgaccactgc tacgcaatga
3046921 cgttagcgaa gcggctaaag gcgatgggct ccgacaagta tcaaaccgat ggtgacccca
3046981 gaacctccgg tccgggattt ggcgtcacca tccatccccg cagtcttgac gagccgttcc
3047041 ggtggcgaag cccccgcaca gtgttcgtga actcgatggc ggacctattt cacgccaggg
3047101 tggcgctctg gttcattagg gaagtgttcg aggtgatgcg agccacacca cagcacactt
3047161 accagatctt gaccaagcgc agcctgcgac tgcgtcgcct cgctcacaag ctggagtggc
3047221 cctcgaacgt ttggatgggg gtgtcggtgg aaaatgtcga cgccttccgc cgtatcgagg
3047281 acctacgaca ggtgcccgca gcagtaaggt tcctctcctg cgagccatta ctcgggcccc
3047341 tggacggaat aaatctaggt tcgattgatt gggttatcgc cggaggcgaa tctggtccaa
3047401 atttccgccc gatcgatcca caatgggttc gccatattcg cgatacctgt actgccgctg
3047461 atgtcccatt cttcttcaag caatggggcg gtagaacacc aaaggcattt ggacgtgaac
3047521 tcgacggacg ttgttgggat gaaatgccgc ttattgagat tagaaacccg gatcctcgga
3047581 ccaccagccg cgtgcacgcg gatcccatgt tggcgacggc gcccacagaa tctgcccagc
3047641 gttcgaatcc tggacagcta gttcgccaac gctgaataat cccatctcgc cacggtcctc
3047701 ggactccttc tgctgtttcg cgctcttggc ttgccgcatc atctctggct ccttttgagc
3047761 cgcccggttg tacaggtggc acatgatcgc atctccggcc cagtgatcgg tcgcgaacac
3047821 catgtcaaag attgtgacct tattgtgcat ctgcatggga atacgatgcg aatacttgta
3047881 tcccagctca tactccagct tgacgcgcat gagattaacc atctcggcac ggtaggcagg
3047941 cgcagttaga tggtggcgcc atcgcgctgc ctgtatccgc ttccaatccg cgtctccgta
3048001 catgcgggtg acctgctcga taaacagttc cgcgttcgtg cccttcacgc cccgcgcgat
3048061 catggtgggt gacatcaaca tccatagttc ggtcttgagg ttacgagggt tctggcgaaa
3048121 ggcggcgacc ttattgatcg tttcccaatg gacttcagcg gcctgttggt cgatgaaagc
3048181 gaaggtgggc gcccaccgcc aagggcctag ttcggcaagt gtttcatcga ttgttacgtt
3048241 ggaatcgccg gccacaacgc ggtacctacc gtcaccggga aagcgggtcc gaagggcgac
3048301 gtccaattca gaggcaagcg ggttaagctc gcaaaaccgg agccgcgtga aaggtggatc
3048361 ggctttcata gcgataagag aagagccatc aaatttctct cccatgtcgc ggtctatgtt
3048421 ctcgggctgg cccgccatca agtcgaggta aattcgttca cgagaagtct gactagccct
3048481 gttgaaggcc gggaggtacc cggcaagtat ctccagtttg tttcgcgtcc aatatgacca
3048541 ttctctagcc atcgaatccc tttagacgcg tcggcgctcc cgctcggcgg ccagctcggc
3048601 gataaccacc tcgcacgcca aggtctggcc gtacccacgg cgcgccaaca tcgccaccag
3048661 cctgcggctc acccgcgctt cgtcggtgcc gtcgtcgatc agcacctccc gccgcagcct
3048721 ggcccgtacc agcttttccg cccgcccccg ttcggcaccg gcgtcgatgc ccccgagcac
3048781 cgtggtgatc acgtcgtcgt cgacgccctt ggcgtgcagc tcggcagcca acgcgcgctt
3048841 gctctttgct gcgttcgccc gcctggactg aacccattgt tcggcgaagt cggtgtcatc
3048901 caccaggcca acggcggcca gccgatccaa tacccggttg ccgatgtctt cggggtagcc
3048961 gcgcttggcc agctggccgg ctaactcggc gcgggtgcgg gatcgcgcgg tgagcaggcg
3049021 caggcacagt gcccgcgcct gctcttcgcg ctcagaagtc gacgggggcg ggcaggacac
3049081 cgtcatttga gggatcatcg gtcaccacgg caccaatgcc aagcttttcc ttgatcttct
3049141 tctcgatctc gtcagccacg tcggcgttct ccaccaagaa gttgcgggca ttctccttgc
3049201 cctggccgag ctgctcgccc tcgtaggtga accaggcacc cgacttgcgg atgaggccct
3049261 gatccacacc catgtcgatc agcgagccct ccctgctgat tcccttgccg tagaggatgt
3049321 cgaactcggc ctgcttgaag gggggcgaac agttgtgcac gacaacccct tcggcgacga
3049381 gggtgtgcag ttcctcgacc tcgaggtcga acgttcgtgc ccgccgcgtt ggcagcactt
3049441 ctcggatcac ggaatagcgg agttcttccg ccagcatgtc gtgcaggaat ttgtcatcca
3049501 gggcatccgc gagcgcctgc acgcgatccc gacgaaggcg gctggcacct aagacctgct
3049561 tcattccacc gcgggggtcc ccggaagcta caccgatcat ggccgcggcc tcctgcgcgg
3049621 tcacgccgcg ctcgtccaga taattcagca cggcatcggt catctctgca gccagatatg
3049681 tcgcttgcga tccacgacgc cgcccctgcg tggcttctgg aatcgcctgg ataagcgcgg
3049741 caccgcgcgg cccccacatg ggaactgact ccgcgaatgc cgtgacgtta tccatacccg
3049801 agatccggac ctcgaacact tgacgtttgc tctggatccg tcgaccgttg acgatgctcg
3049861 gccgcttctg ggtcggatcg taatctcgaa cggtgctccc gacaccgaac cgcagcagca
3049921 gccaatgaat ctgatgcgcg agttgttcag aggtcgtcgt gtaaccgacc cgaagtgccc
3049981 cggtctgttc ccggctcacc cacccgtcgc tttcgaacag gccgaagagc agattgccga
3050041 caatgtcggc cgcgatgtcc ggctcgaaga accaattcgg aatcgtcttc tcccacgcga
3050101 gcttgccgta gataccggcc tgctgacaaa ggtctgccac accgttgcgc tcaccgggtc
3050161 gatgagcgat cgcgagtgag atacgcccct gcggatgggc cgcgcaaccg agcgtcgcag
3050221 cgattcgcgt cacgtcgtca atgagcgccc gctgaacatt gatgaagttg atcggagtct
3050281 tgccccccac ccaaccatcc ctgccatctc cgatcaggta gccaagcagc cgggcatgat
3050341 ccgccggaat cggcgcactg tcaccgaatc catcgaagcg tcgcggttgc gccaccctgt
3050401 ctcccttgcg gagttccccg gcggcacgcc agccgtactc tgtcagcacc ttgtgatcgg
3050461 gtgtcgccca cacgatggcg ccaccggcga tccgcaaccc gatcacatcc cgcgttccct
3050521 ggtcgaacca ggacaccacg ggccgcgcat gcagcgttcc gtccttggca gcagccacga
3050581 catgaatagg cttgcgccca tcgacaacat cctcgatgcg atgcgttgta ccggtgaccg
3050641 gatcgaagat ccgagtgccc tctgcgaggc acttgttctt gacgaccttg acccgggtgc
3050701 ggttgccgac cgcgttggta ccgtccttga gcgtctcgac tcgccgcacg tccatgcgca
3050761 ccgacgcgta gaacttcaac gcctttccgc ccgttgtcgt ctcgggcgac ccgaacatca
3050821 ctccgatctt gtcgcggagc tggttgatga agatcgccgt ggtgcccgaa ttattcagcg
3050881 cgccggtcat tttccgcagc gcctggctca tcagccgggc ctgcagcccg acgtggctgt
3050941 cgcccatctc gccttcgagc tccgcgcgcg gcaccagcgc cgccaccgag tcgatcacca
3051001 cgatgtcaag cgcacccgag cggatcagca tgtcggcgat ctcgagtgcc tgttccccgg
3051061 tgtccggctg gctgaccagc agcgaatcgg tgtcgacacc gagcttcttg gcatagtccg
3051121 gatccagcgc gtgctcggcg tcgatgaacg ccgcaacacc accggcggcc tgagcgttgg
3051181 ccaccgcgtg cagcgccacg gtggtcttac ccgacgactc cgggccgtat atctctatca
3051241 cccggccacg cggcaggccg ccaatgccca gggccacgtc tagtgcgatg gatccggtcg
3051301 gaatgaccga aatcggctga cgcgcctcgt cgccgaggcg catcaccgaa cctttgccgt
3051361 aactcttctc gatctgggcc actgccagct cgagcgcctt ttcccgatcg ggggtctgcg
3051421 tcatggtgcc tctcctgtgg tcggtgttcg attgaccggt atcggtcggt tggccgtgac
3051481 actagagaca gccactgaca agtcggctgc tccgaatgat caccacagta gccgaacacc
3051541 tgttcgattc aagtgtgaca cgccgcgtgt ggcaacatcg cgtccgcgct cgtcggcgcg
3051601 tcgaacgccc tggcggcggt gcggcccgac ttgcgtgcgc ggctggtccg gatcaccgac
3051661 gatctgctca acaccgctag cctggccgga tccggcgtgc tcaccggccc ggatctgacc
3051721 tttcggcgtc gcagctgctg cctgttctac cgggtacccg ccggaggcaa gtgcggcgat
3051781 tgcccgcttt gacgaatgtg caacctcacc accgatcgtg gggaacgtcg aagtcggcgc
3051841 acaatgcccg ccagacgtcg cggggctcga caccgtcctc gatggcctgg gcggcgctac
3051901 ggccgtcgaa gccggtcagc acgtgatcga gcagcaccga cgagccataa gccgccccga
3051961 aatgcagggc tacccgctcg tggaactccg tcagccgcac gccagccaac atacccagcg
3052021 cgctaccccg ccaacgcaag cgcgtcgtgg cagacccgca ccggatcggc cgcaccggcg
3052081 acgctggcgg ccgcccgccg cgcggcctcc cggaacctcg gcgacgacaa cacctcgttg
3052141 accgccgcca ccagcgcgtc ggcggtcaac ggccggatca gcaccgcgct accctgccgg
3052201 actacccggt tggcgatctc ccactgatcc ccgccaccgg gaaccaccac catgggcacc
3052261 ccggccagca gcgtcttggc caccatccca tgaccaccgc cgcagatcac cagatcggcc
3052321 cgcgtgagca gctcggcctg gctgcccagc ccggccaccg cccagggcgg caccgtcagg
3052381 tcggctccgc tcaaacgcga caccaccagg cgcgatcccg acggcaccgt ctcacccggc
3052441 gtcagagact gcaacgcgac ctccgtcaat ccggcggtcc cggtcaacgc ggtggacggc
3052501 gccacgacca ccaccggccc ggtgccggcg gggatggcca gcacccgatc ggtcggctcg
3052561 aaatgcagcg ggcccaccac gacggcctcg gccggccagt ccgggcgggg aacctcgagc
3052621 gcgggcagcg tggcgatcag ccggcgcagc ggcccgggat cgcgggccgg caatccgatc
3052681 tcgacccgaa cggcggcacg ctggcgcagc ccggcacgcc aggaccgccc cgtcagcgct
3052741 cgcatggtgg catcgcgcag ccggccgcgg ataccggtgc ctgcagccag tccgctgccg
3052801 atcggcggca gtcccttcga cggcaggtac agcggatgcg ggttgagttc cacccacggg
3052861 atccctagca gttcggctgc catgccgccg cacgccgtga tgacgtcgga caccaccagc
3052921 tccggttcca gagcccgcag ccgcggcacg ttgagcacgg ccatctgcgc cgctcgccga
3052981 tggatcctgg ccccggcgtc gagatcgcgg tcggtggccg ccagcccgtc cagctcgacg
3053041 gcgtcaatgc cagcggcgcg ggcggcttcc agccattcca ccccggtgaa cagggtgggc
3053101 gtgtcagcgg ctgcgcggaa acgctggcac agcgcgatcg ccggaaacga gtgcccggga
3053161 tccggcccgg cgaccacggc gacgcgcatc ggccctaccc tgccacagcg ccacagccgt
3053221 aggctgacag ccatggccga gctgaccgaa acatcgccgg aaacccccga aaccaccgag
3053281 gccattcgtg ccgtcgaggc gttcctcaac gccctgcaga acgaagactt cgacaccgtc
3053341 gacgccgcac tgggcgacga cctggtctat gagaacgtcg ggttttccag gatccgcggt
3053401 ggccgccgca cggcaacgct gcttcgccgc atgcagggcc gcgtcggctt cgaggtgaag
3053461 atccaccgca tcggcgccga cggcgccgcg gtgctcaccg aacgcaccga cgcgctaatc
3053521 atcggaccgc tgcgggtgca gttctgggtc tgcggcgtat tcgaggtgga cgatgggcgg
3053581 atcaccctgt ggcgggacta cttcgatgtc tacgacatgt tcaagggcct cttgcgaggc
3053641 ctggtggcgc tggtggtgcc atcgctgaag gcaacgctgt aggccgacct tccggatcaa
3053701 gcccaacgcg ctgtagaaca tcgggtagcg ctacagccag ccggctgccc gggcttatcg
3053761 ctactctgcg cggcgggcca gcaaagatgc gaagtgtggg cgaaaccgca aatgcatcgc
3053821 ctcggccgct atacgatccc catgcacagt cttgagggtg agctggcgat tttgggccga
3053881 cacgacgggc tgtggcgtgt ttggaggtct cagatgtcat ttgtgatcgc ggcaccggag
3053941 tttttaacgg cggcagcaat ggacttggcg agcatcggct cgacagtgag cgcggccagt
3054001 gccgccgcat cagcccccac ggtcgcgatc ctggccgcgg gcgccgatga ggtgtcgata
3054061 gccgtcgcgg cgctgttcgg aatgcatggc caggcatatc aggccctcag cgtgcaggca
3054121 tcggcgtttc atcagcaatt tgtgcaggcc ttgaccgcgg gcgcgtactc gtatgcctcc
3054181 gctgaagccg ccgccgtgac accgcttcag caactagtcg atgtgataaa tgcgcccttc
3054241 agaagcgcgc tcggccgccc cctgatcggc aacggcgcca acggtaaacc ggggaccgga
3054301 caagacggcg gggccggcgg actcttgtac ggcagcggcg gtaacggggg atcagggctg
3054361 gccggctccg gccagaaggg cggtaacgga ggagctgccg gattgtttgg caacggcggg
3054421 gccggcggtg ccggcgcgtc caaccaagcc ggcaacggcg gcgccggcgg aaacggcggc
3054481 gccggtgggc tgatctgggg caccgcgggg accggtggca acggcgggtt caccaccttt
3054541 cttgatgccg ctgggggtgc cggcggggcc ggcggcgccg gtgggctgtt cggcgcgggc
3054601 ggggccggcg gcgtaggcgg cgccgccctc ggcggcggcg cccaggccgc cggtggcaac
3054661 ggcggtgcgg gcggggtcgg tgggctgttc ggcgccggcg gtgccggcgg cgccggcggc
3054721 ttcagcgaca ccggtgggac cggcggggct ggcggggccg gcgggctgtt cggcccgggc
3054781 ggcggctcgg gcggcgtcgg tggcttcggc gacaccggtg ggaccggcgg cgacggcggc
3054841 agcggcgggc tgtttggcgt cggcggggcc ggcgggcacg gtggcttcgg cagtgctgcc
3054901 ggcggcgacg gcggcgcggg cggcgccggc ggcacggtct tcggctcggg cggggccggc
3054961 ggtgcaggcg gagtcgccac tgtcgctggc cacggtggtc acggcggtaa tgccggcctg
3055021 ctatacggca ccggtggggc cggcggagcc ggcgggttcg gcgggttcgg cggcgacggc
3055081 ggcgacggcg gtatcggcgg gttggtcggt tctggcggcg ccggcggcag cggcggcacc
3055141 ggtaccctaa gtggtggtcg cggcggggcc ggcggtaacg ccggcacgtt ctacggttcc
3055201 ggcggcgccg gcggcgccgg cggggagagc gacaacggcg acggcggaaa cggcggcgtg
3055261 ggcggcaagg ccgggttggt cggcgagggc ggcaacggcg gcgacggcgg tgccacgata
3055321 gcaggaaagg gtggtagcgg cggtaacggc ggcaacgcct ggctgacggg ccagggcggc
3055381 aacggcggca acgccgcatt tggcaaagcc gggactggca gcgtcggcgt cggtggcgcc
3055441 ggcgggctgc tggagggcca gaacggcgag aacggattgc tgcctagctg agccagctta
3055501 gccgcagctt ggcctcagcc accgggcgtg cggcggccca tcgaccgagg cacgtcgaaa
3055561 tcggtgcaca acgcccacca cgcgacgcgg ggctcaaccc cgtcctcgat cgcgcagatg
3055621 gcattgcgcc caccgaaacc ggtcagcaca tggtccaacc agcaccaaaa gcccggtacg
3055681 ccgcgccgaa tcgcgggctg accaactcgt ggaactccgt ccgccgtatg ccgccaaccg
3055741 cgtgcgtcag cgccttgtgg cacacccgca ccggatcggc tacctaaccc gcgccggccg
3055801 ctgccttggc gcggcacccg gtcggccatc caccgcagat ccccgccacc gaacgcaccg
3055861 aaacgccgac cttcggcccg cttcgtatcc ggttctgggc ctgcggcatt ttcgaggtac
3055921 aacgggcacg ctatggcatt accacttcgg cgtccaaggc gctggtgcgc ggtctgaccg
3055981 cgtcggcgtt ctcgtcgccg cgggctaccc tgtagcgaat gagcgacaac gcaatccgcc
3056041 cgcggcccaa cccgtggcag tacatccgct attgctacgg ggcgcggctg ccggactcga
3056101 tgcgagactg ggtgcgcaac gatctggccg gcaagggtgc ggccatccgg atgatgatcc
3056161 gcgtcgcggt tccggcggtg ctggtgctgg ccccgttctg gctgatcccg acgtcgctgg
3056221 acgtccactt gagcatgacg ttgccgattc tcatcccgtt cgtgtatttc tcgcatgcgc
3056281 tgaacaaggt atggcgccgg cacatgctgc gcgtgcacaa tcttgacccc gagctcgtcg
3056341 acgagcacgc ccgccaacgc gacgcccaca ttcaccgggc gtatatcgaa cgctacgggc
3056401 cacggccgga cccgaacgac taacgccggg gcaatccgcc gagctcgtca aacgcctgcg
3056461 cccaagcgac caggcgatcg gtggcgccgg ccaactcctc gcggtagcgc tgttgtccgg
3056521 gcccagcccc acccgcgccg ttcgccgagg aaaccaattg cgctgcggcg gtgaccattt
3056581 cgttgtactg acggacgccg gtgctcagct gcgcggtaaa cgcgttgatg gtcggcacca
3056641 gatacgaccg cgacgccgcc gagcattgca cggcccgctc catcgagacc acctcggccg
3056701 cggtcgccac catcgccgcc gaagtctggt tggccgcggc cgttaggtcg cggatctcgt
3056761 ccgccggcaa catggcgccc cgctccatga cacccaacag cgagaagaac ccgcgttcgg
3056821 aggcgcccag cgccgacatc gcgggtcgcg cggccgagcc cggtggtggc agccggcgca
3056881 cacttgcggg ccgccgcacc ggcagtggct ccgagcgcag ccagcggtag cgaagcagca
3056941 atagcgtcgc cggaatggcc tgcgtgaccg caatcgtgcc ggtaatcacc agcagcgacg
3057001 taaaccagcc ccaggccgcc aacagcgccg tcaccaaccc ccagagcaga cagcctgcgg
3057061 tgaataccag accccagcgc aatgcacggc ggcggcggcg cagcagccgg gcacgcggat
3057121 cgatggcgac gctgatcttt tgtgctacca ggtcggccaa atcaccggcg gtatccacgc
3057181 cgcgctgcag caacgaacgc cacggccggc gctgacccgc tttcactgcc atgccgaacc
3057241 gtctgcccaa ctactgaccg tagggctgct cggcaatagc cccgccagaa gtctcggtgg
3057301 ccggtctggg ggtagccgtg gtcccgccgg ccggcaacgc ttcaccgcgc atcgatgcgc
3057361 ggatctgttc caaccgtgaa tgaccggcca tctggatccc ggcctgctcc acctcgagca
3057421 tccggccctg caccgaactc tcggcaagtt cagccgaacc gatcgcgttg gcgtagcgac
3057481 gctcgatctt gtcgcgcacc tcgtcgaggc tcggcgtgtt gcctggcgcg gcgagctcac
3057541 tcatcgaccg caacgatgcg ctgacctgct cctgcatctt cgcctgctcg agctggctga
3057601 gcagcttggt tcgctcggcg atcttctgct gcagcaccat cgcatttcgt tcgacggcct
3057661 tcttggcctg agctgcggcg ctaagcgcct ggtcatgcag cgtcttgagg tcttcgacgc
3057721 tctgctcggc ggtcaccagc tgggctgcga acgcctcggc ggcgttgttg tattcggtgg
3057781 ccttggcagc gtctccggcg gcggtggcct ggtcggccag cgtcagggct tggcgcacat
3057841 tgacctgaag cttttcgatg tccgccagct gtcggttgag tcgcatctcc aattgacgct
3057901 ggttaccgat cacttgcgcc gcctgttgag tcagcgcttg gtgggtgcgc tgtgcttcct
3057961 caatggcctg ttgaatctgc accttggggt cggcatgctc gtcgatcttc gagctgaaca
3058021 gcgccatgag gtacttccag gctttaacga acggattggc catcagttag ctccgccttc
3058081 gcttcttgtg tgcgccagat ggtctcagcg ccctgtcgct caatttatcg ggtcagcgcg
3058141 cattgcccca cccatggcgc gcatcttgtc gacccggacc gaccggcgac ccttaggcca
3058201 ccgccagcga caccaccggc gcaatgacga ccttggtgct ggcgtcaatg gtggcgccgg
3058261 ttgctctgcc agccggggtg gcgcgggcaa ggcgctcttg acgcgccatc cgctcgcccg
3058321 catcgatgag caccaccgac aacgggagct gcagagccgt acaaatcgca ctgagcagct
3058381 cgctggaagg ctccttgcga ccgcgctcga tctccgacag atacccgagg ctcacccgcg
3058441 ccgaatcgga cacctcgcgc agcgtccgac cctgcgacat ccgcgctccg cgcagcacgt
3058501 caccaacgac ctcacgcacc aaagccgcca tcaaaaactc cttgtccacc tcgcaatcgt
3058561 catcaggtga acgccgccgg cggtggggtt ggttcccgca atcagctggc ggtctggcgg
3058621 atccccccga tgtcccgcag agccctggcc acgtaatcga caccagtgat cacggtgagc
3058681 aggatcgcgg cggccatcac taccaccgcc gcaacgtgca gcggacccga aagtggcaac
3058741 acgaataagc caattgccac cgcctggaca aaggtcttca gcttgccgcc ccagctcgcg
3058801 ggaatgacac cgcgcctaat aaccgccaac ctcaaaacgg tcactccgag ttcgcgggtc
3058861 aggattagca ccgtgaccca ccacggcaag tcgccgagca tcgacaatcc gatcagcgcc
3058921 gagccgatca gagtcttgtc cgcgatcgga tcgacaaacg caccgaattc ggttgccatc
3058981 ccgtaattgc gagccagcag gccgtcgaat cgatcggtaa tgcaggcggt tgcaaatatc
3059041 gcccacgcca ctacgcgggc cgcggagtgg tggccgccgc catagaacaa ggccagcagg
3059101 aagaccggga ccatcaccag ccgcaacagc gtcaggatat tggcgaggtt ggcaatgcgg
3059161 gcgcggcctg ctatctgacc cgtttcaggc tgcgccgaca cggcaacaga ataacgggtt
3059221 gacctgctca tgcgaccctt gatgtcgata ctgtttcaca cgtgaccgaa cgtccacggg
3059281 attgccggcc ggtggtccgg cgcgcgcgaa cctccgatgt gcccgcgatc aaacaactcg
3059341 tcgacaccta tgccggaaag atcttgctgg aaaagaatct cgtgacactc tatgaagcgg
3059401 ttcaggaatt ctgggtggcc gagcacccgg acctctatgg caaagtcgtc ggttgcggtg
3059461 cgttgcacgt gttgtggtcg gatctcggcg aaatccgcac cgtcgctgtc gacccggcca
3059521 tgaccggcca cggtatcggc cacgcaatcg tcgatcggct actgcaggtc gcccgcgatc
3059581 tgcagctgca gcgcgtgttc gtgttgacct ttgagaccga gttcttcgcc cggcacggat
3059641 tcaccgagat cgagggcacc ccggtcaccg ccgaggtgtt cgacgagatg tgccgctcct
3059701 atgacatcgg ggtcgccgaa ttcctggacc tgagctacgt caagcccaac atcctcggca
3059761 actcccggat gctgctggtg ctgtagcccg gcgagcagac gcaaaatcgc ctcatttcgg
3059821 cacgaaatgg gcgattttgc gtctgctcgg cgggctactc gccgccgtca ccccggatcg
3059881 cggccagtgt gcccgccaac tcgtcgggct tgaccagcac ctcacgggcc ttcgagcctt
3059941 cgctgggccc gacgatgccg cgggtctcca tcaggtccat caaacggccc gctttggcga
3060001 agccgacccg cagcttgcgc tgcagcatcg acgtcgaccc gaactggctg gacaccacca
3060061 gttccacggc ctgcaggaag acgtccatgt cgtcgccgat gtcggggtcg acgtcggtgc
3060121 gctccgcggt gggtttagcc gtggtgacgc cctcggtgta ttcgggttcg gcctgttcct
3060181 tgcaggcggt gacgacggcg tggatctctt cgtcggagac gtaagcgccc tgcagccgga
3060241 ggggtttgct cgcacccatc ggcaagaaca ggccgtcgcc catgccgatc agcttttccg
3060301 cgcccgcctg gtccaggatc acccggctgt cggtcagcga cgaggtggca aacgccagcc
3060361 gcgacggcac gttggtcttg atcagcccgg tgaccacgtc caccgacggg cgctgggtgg
3060421 ccagcaccag gtggatgccg gcggcgcggg ctttctgggt gatccgcacg atggcgtcct
3060481 cgacgtcacg cggcgcggtc atcatgaggt cggccaactc gtcgacgatg gccaccacgt
3060541 aggggtaggg ccgatactcg cgctggctgc ccagcggcgc ggtgatggcc ccggatcgca
3060601 ccttgtcgtt gaagtcgtcg atgtggcgca cccgggaggc ctgcatgtcc tggtagcgct
3060661 gctccatctc gtcgaccagc caggccagcg cggccgcggc cttcttcggc tgggtgatga
3060721 tcggcgtgat cagatgcgga atgccttcat acggcgtcag ttccaccatc ttcgggtcga
3060781 tcaggatcat cctgacctct tccggggtgg cccgggtcaa cagcgacacc agcatggagt
3060841 tgacgaagct ggactttccc gagcccgtcg agccggccac cagcaggtgc ggcatcttgg
3060901 ccaggttggc cgagatgaag tcgccttcga tgtccttgcc cagcccgatc accaacggat
3060961 gatggtcgcg acgggtctct cgtgcggtga gcacgtcggc caaccgcacc atttcccggt
3061021 cggtgttggg tacctcgatg ccgacggcgg acttgccggg gatcggtgcc agcatgcgca
3061081 cgctctcggt agccaccgcg taggcgatgt tgcgctgcag cgcggtgatc ttctcgacct
3061141 tgacgccggg ccccagttcg acctcgtagc gggtgacggt gggcccgcgg gtgcagcccg
3061201 tgacggccgc gtcgaccttg aactgggtca gcacctcacc gatggcgccg gccatgtggg
3061261 tgttggccgc actgcgtttc ttgggcggat caccggatat cagcaggtcc agcgacggca
3061321 gcgtgtaggg accctcgacg atccggtcca gcacttgggt atctttgcgg cggccgcgtc
3061381 ttccggagcc ccgaccggcg gaggcttccg gtatcgtcgc agtgtcatcc tgcggaacct
3061441 cggccgacgg ccaggccggt ggcccgtcgt cggagcacag gggcacctcg tcgtagtaac
3061501 cgtcggagaa gtcctggcgg gcgacttcga cggtgtccgc gtcgtcacca tcgaagtccg
3061561 cgaagtcctc gaagtcgtcg gcgtattccc gtggcaacag ccgggtgccg aacatggcgc
3061621 gcatggcatc tggcacctct cggatcgtga tcccggccag caggagcaat ccgaacagcg
3061681 cgccgatgaa taacagcggc gcggcgatcc aggcggtcaa cccgtccgag agcggcccgc
3061741 cgatcgcgaa accgatgaac cccgcggcgc gcaaacgcga ctccggggcc tcgggtgagc
3061801 ccgcccacag gtggcacaag ccgagaaacg acaagccgat caggctggcg ccgaggatca
3061861 gccgcggccg cgaatcgggg ttgggcgacg tacgcatcag caccacggcc acggcggcgg
3061921 caaccagcgg gagcatgacc actgccgacc cgatgaacgt ccgcaacaag gcgtcgaccc
3061981 acgcgccgag cggccgggcg gcgtcgaacc acgagctcgc ggcgactacc acggcaaggc
3062041 cgagcagcac cagcgcgatt ccgtcgcggc gatgcccggg ctcgatgtcg cgggctcgcc
3062101 cgatcgaccg cgccgcgccg ccggtgccct tggccgccat catccagacg gcacgcatgg
3062161 cccggccgca ggcgagtccg gtagacacca gcagcgaccg atggtgccgt cgggagggtc
3062221 tgccgacccc tttgacgggc ctcgacctct ttctgggcac ggccgatcgc gcacttcggg
3062281 acgcgccccg cgaagtggcc tttgacctgc tcgttcgagt gccggagcgg gcaacggtct
3062341 tgctagacat aacggcaagc ctagtcgcta tcacaccatc tacaccatcc gccacactgg
3062401 taacggcgat ctgctcgcct cgttgccagg gtctcctgag tagggtgaca agtgatcgtg
3062461 ccgcgtcacg ccgcccgacg cgcggagttc caggaggccc cagcatgccc gtcgtcgtcg
3062521 tcgccacgct gaccgccaag cctgaatcgg tcgacaccgt ccgcgacatc ctcacccgcg
3062581 cggtcgatga cgtgcaccgc gaacccggct gccagttgta cgcgctccac gaaaccggcg
3062641 agaccttcat cttcgttgag caatgggccg atgccgaggc gctcaaggcc catagcggcg
3062701 cccccgcggt tgccaccatg tttaccgcgg ccggcgagca cctggtcggg gcgccggaca
3062761 tcaaactgct gcagccggtt cccgccggcg acccgagcaa agggcagctg cgccggtgat
3062821 cgaccggcca ctcgaaggca aggtcgcctt catcaccggc gccgcgcgcg gcttgggccg
3062881 cgcacacgcg gttcgactgg cagccgacgg cgcgaacatc atcgcggttg acatctgcga
3062941 gcagatcgcc agcgtgcctt atccgttgag caccgccgac gacctggcgg ccaccgtcga
3063001 gctcgtcgag gacgccggcg gcgggatcgt ggccagacag ggcgacgttc gcgatcgcgc
3063061 atcactgtcg gtcgcattgc aggcgggcct tgacgagttc ggccggctcg acatcgtggt
3063121 ggccaatgcc ggtatcgcga tgatgcaggc cggcgacgac ggctggcgcg acgttatcga
3063181 cgtcaacctc accggcgtct tccacaccgt acaggtggcg atcccgaccc tgatcgagca
3063241 gggcaccggt gggtcgatcg tgttgatcag ctcggccgcg ggactggtcg gcatcggcag
3063301 cagtgatccc ggatcgcttg gctacgcggc cgccaagcac ggcgtcgtcg gcctgatgag
3063361 ggcgtacgcg aaccatctgg caccgcaaaa cattcgggtt aactcggtac atccttgcgg
3063421 ggtcgatacg ccgatgatca acaatgagtt cttccagcag tggctaacca ctgctgacat
3063481 ggacgcgccg cacaacctgg gtaacgcgct gcccgtcgag ctggtgcagc caaccgacat
3063541 cgccaacgcg gtggcatggc tggcgtccga ggaggcgcgc tatgtcaccg gcgtcacctt
3063601 gccggtcgac gcgggctttg tgaacaagag gtagctgatg gctcgaaatc ccgctgcgca
3063661 gaccgccttc ggcccgatgg tgttggcggc cgtggagcaa aacgaaccac ctggccgccg
3063721 cctggtggac gacgacctcg cggacttgtt cttgcccaga ccattgcgat ggctggccgg
3063781 tgcaacccgg tcggcggtgt tgcgtcgttt actcattagc gcctcggagt ggtccggccg
3063841 cgggttatgg gccaatctgg cctgccgtaa acgcttcatc ggagacaaac tcgacgaagc
3063901 gctcggcgac atcgacgcgg ttgtcatcct cggagccgga ttggacaccc gtgcctaccg
3063961 gttgacgcga cgagtgcgga tgccggtatt cgaggtcgac ctgccggtca acatcgcccg
3064021 caaggccaag acggtccgac gggtgctcgg tgaactgccg ctgtcggttc gcttggttgc
3064081 attggatttc gagcatgacg acctgctcac cgctctggcc gagcacggct accgtaccga
3064141 gtaccgggtg ttcttcgtct gcgaaggtgt gacccaatac ctcaccgagc gggccgtccg
3064201 gcggaccttg gagggcctac gcgcggccgc accgggcagt cgaatggtat tcacctacgt
3064261 ccgccgggac ttcattgacg gcaccaaccg ttacggtacc cggacgctat accacacggt
3064321 tcgccagcga cgtcaactgt ggcacttcgg cttagatccc gaggaagtag ccgggtttct
3064381 cgccgactac ggttggcggc tgaccgagca ggccgggccg gaggagcttg tccagcgcta
3064441 cgtcgagccc accggccgca acctcaacgc atcacaaatc gagtggtctg cctacgccga
3064501 gaagagtgag ccggttacac ctcgatgacc gtcggcacaa tcatcggctg gcggcgatag
3064561 gtttccccca cccacttgcc gaccgtgcgg cgcacccctt gagcgatccg gatcggatcg
3064621 gtgacgttgg cggccaccaa cgattccagc tctgcctcca ccttgcgcac ggcgggttcg
3064681 agcgccttgg gatcttcgga gaaaccccgc gagtgtagat gtggcgcagc caacggctgg
3064741 ccggtgccac gtctgaccac gacggtcacc gcgacaaagc ccgacgacaa aatgagccgc
3064801 tcgcccaggg tgatatcgcc gacgtcgccg gcgatcaagc cgtcgacgaa catcttgccc
3064861 accggcaccg caccggagat actggctttg ccggcaacca ggtcgacgct gacaccgttc
3064921 tcggccaaca gaattgactc ttgcggtacg ccggtactgg cggccagctt ggcattggcg
3064981 cgcagcatcc gccaggttcc gtgcaccggc atcacgttgc gcggccgcac cccgttgtag
3065041 aggaacagca gctcaccggc gtacgcgtgg ccggaaacat gcacccttgc ttgggcgttg
3065101 gtgacgactc tggcgccgat cttggacagt gcatcgatga ctccgaagac cgcctcctcg
3065161 ttgccgggga tcagcgacga cgacaacacg atgagatcac cagcagtcaa cgtgatgctg
3065221 cgatgctccc cacgcgacat tcgcgacaac gccgacatcg gctcgccttg ggtgccggtg
3065281 gtgatcaaca caacttggtc gggcgccatc gtttcggcgg cggcgatgtc gatgagatcg
3065341 gaatcagcca ctcgtaggaa gcccagttgc cttgcgacgc gcatgttgcg caccatcgat
3065401 cggccgacga acgacactcg ccggcccaat gccactgcgg catcgatgat ctgctgtacc
3065461 cgatccacgt tggaggcgaa acacgcaact atcacccgtc cgtcggcacc ccggatgagc
3065521 cggtgcagcg ttgggcccac ttcgctttcc gatggcccga caccggggat ctcggcgttc
3065581 gtcgagtcgc acagcaacag gtccacgccg gtgtcgccga gccgcgacat gcccggtaga
3065641 tcggtgggac ggccgtccgg tggcaattgg tcgaacttga tgtcgccggt gtgcaggatg
3065701 gttcccgcgc cggtatacac cgcgatggcc aacgcgtccg gagtggaatg gttgacggcg
3065761 aagtactcgc actcaaacac gccgtgccgg gtgctctggc cctcgcggac ctcgacgaac
3065821 accggtgtta tgcggtactc acgacatttc tctgcaacca gagccaaggt gaacttcgag
3065881 ccgacgaccg ggatgtcggg tcgcagcttg agcagaaacg gaatcgcccc gatgtggtcc
3065941 tcgtgcccgt gggtcaacac cagcgcctcg atgtcgtcaa gccggtcttc gacatggcgc
3066001 atgtccggca ggatcagatc gacaccgggc tcgtcgtggc caggaaacaa cacaccgcag
3066061 tcgataatca acagtcggcc caggtgttcg aaaaccgtca tgttgcggcc gatttcgttg
3066121 atgccgccca gcgcggtgac ccgcaacccg ccggaggtca ggggacctgg cgggggaagg
3066181 tctacatcca cttctgggcc accctttggc tcacctttag atcaccgaag caccgaggcc
3066241 gcgcgcatgt cggcggccaa cgcgtcgatc tgctccggtg tcgcggccac ctggggcagc
3066301 cggggatcac cgacgtcgat gccctgcagc cgcaagcccg ccttggacaa cgtcacccca
3066361 cccaggcggc tcatcgcgtt gcacagcggg gcgaccgcaa tgttgatctt gcgggcggtg
3066421 gcgatatccc cagaaccgaa ggcggacaac aactctcgaa gctgcccggc tgccaggtgg
3066481 gcaatcacgc tgatgaagcc cgtggcgccc atggccagcc agggcaggtt gagcgcgtcg
3066541 tcgccggaat agtaggccag tccggtgtcg gccatgattt gggcgccgct gtgcaggtcg
3066601 gctttggcgt ccttgactcc gacgatgttc ggatgcgacg ccaacgcgcg gatcgtgtcg
3066661 ggctcgatcg gcaccgccga ccgccccggg atgtcataga gcagcatcgg cagctcggtc
3066721 gcgtcggcga cggcggtgaa atgggcttgc agcccccgct gcggcggctt ggaatagtag
3066781 ggcgtgacca ccagcagccc gtgcgcaccc tcggccgcac aagccttggc cagccggatg
3066841 ctgtgcgcgg tgtcataggt gccggcaccg gcgataacac gggcccggtc ccccaccgct
3066901 tccaagacgg cccgcagcag ctcgattttc tccccgtcgg tggtggtcgg cgactcgccg
3066961 gtggtgcccg agaccaccag accgtcgcac ccctgatcga ccaggtggtt ggccagccgc
3067021 gccgcggtgg cggtgtccag ggagccatcg ccgctaaacg gtgtcaccat cgcggtcagc
3067081 agggttccta ggcgcgctgc gacgtcgaat ccgacggtgg tcacggctcc caaggttacc
3067141 tggcgcttta tcccggccgc gagcgcgcgt gtttgtccag cgacacgccg cctcaggctt
3067201 cggtcgccaa cgggctggtc gccacctcgg tgccgtcggc cagggtggtc acctcgaagt
3067261 cggcgaacac cgcgggggcc acggcggcga gctggcgcag gcattcgatg gccagtcgcc
3067321 ggatttccac gtcggcgtgc tcgctggccc gcattgcgat gaagtgccgc caggcccggt
3067381 agttgccggt caccacgatg cgggtttcgg tggcgttggg cagcaccgcg cgggcggctt
3067441 ggcgggcctg cttgcggcgc aggatcgcgt tgggttggtc ggcgaacttg gcttccagct
3067501 tggccagcag ctcgctgtag gtggcgcggg cggcgtcggc ggcctcggtc aggatgtggc
3067561 gcaggtcggc gtcgtcctcc atgccgggcg gcacgacgac ccgcgagtcc ttctcgggta
3067621 cgtagcgctg ggagagctgc gagtaggaga aatgccggtg gcggatcagc tcgtgggtgc
3067681 acgatcgcga gatcccggtg atgtagaacg acacgctggc atgctctagc accgagaaat
3067741 gtccgacgtc gatgatgtgc cggaggtagc cggcgttggt ggcggtcttg ggattgggct
3067801 tggaccagct ctgatagcag gcccggccgg cgaactcgac cagcgcgggt ccgccgtcgg
3067861 cgtcggtggt ccagggcacg tcgggtgggg ccaagaagtc ggtcttggcg atcagttgca
3067921 cgcgcagcgg cgcggtctcg gccacggcgc tcaccttagc gccggccgca actagacgaa
3067981 ctcggtgtgg caggtcagcc cgggctcccg gcgcagacgc gggtccgcgg tcagcagggg
3068041 gatgtcgagg tgactggcca gtgccacgta gagggcgtcg taaaacgtga agttgtgccg
3068101 cagggtccac gcccgtcgag cgtccgcgtt ggcgctggct cccagagttg aaccccacca
3068161 aatctgttgc ctgaagaagc cgatctacct aacggggatc gttgcccttg aagtcgcgaa
3068221 caaataggca agtgtccagc ggccagatcg gacccgcaac gaaagttgcg gtaccaatcg
3068281 ccgcaccgct cctgccgatg gctacaccgg gaccatcgta cgcagctgtg tcatgcatac
3068341 cggtcacccc gaatgacccg ataacaggta ccgttccaga tccccgcgac gccgcaggaa
3068401 gatcatgtcc tcgctgcagc tcaaggactt ccccgaaccg caaggttttc catccatcac
3068461 tcatctaagc cgccccagtt gctcccgcac gaccctttcc agccgcgccg actcatcgaa
3068521 cgcctccagc aacgccttcg acaaccgggc catcttctcg tcgatcggct ctccgtcgtc
3068581 ctcgaccgcg ggcgtaccca cataccgccc cggcgtgagc gcatagtcgg tcgccttgat
3068641 ctccgccaac gtcgccgact tacagaaccc cggaacatcc tcgtacataa tccctttgac
3068701 ggcagccgac ttcgacccgc gccacgcgtg gaaggtatcc ccgatgcgga cgatctcctc
3068761 gttggtcagc gcccgctcgg cccggtccac taggtcgccc agttcacgag cgtcgatgaa
3068821 cagcacctgc ccgcaccggt cgatagaccc ttgcttacct gccgccttgt ctttggcgaa
3068881 aaaccacagg cacaccggga ttccggtgct gcggaacagc tgggtgggta acgcgaccat
3068941 gcaggaaacc aaatccgcct ccacgatctg cgcgcgaata tccccctcgc cgttggagtt
3069001 cgacgacatc gacccgttgg ccatcaccac gcccgcccga cctcccggcg ccaacttgta
3069061 caggatgtgc tgaatccatg cgtagttggc gttattggcg ggcggaacac cgaagcgcca
3069121 gcgtgggtct tcctcgttgc gggcccagtc tttgatgttg aacggcagat tggccatcac
3069181 gtagtccatc tgcacgtccg ggtgctggtc gcgggcgaag gtatcactcc atcgggcgcc
3069241 gagccccttg ttgtcgatgc cgtggatggc gaggttcatc ttcgccatcc gccaggtctc
3069301 ctcaatgctt tcctggccat agatcgagac atccttcgga tcgccgtcgt gttcgtagat
3069361 gaacttctcg gtctgcacaa acatgcctcc ggaaccgcag cacgggtcat acacccgccc
3069421 actcgacggc tccagcacct ccacgatcac cttgaccacg ctgggcgggg taaagaactc
3069481 gccaccccgc ttcccttccg cgcgagcgaa attgccgagg aagtattcgt agacctcacc
3069541 catcagatcc cgggcgcggt gctcgccctg ccggctgaag cgcgcactgt taaataggtc
3069601 gatcagctca ccgagccggc gctggtcgat gttgtccttg ttatacagcc tcggcagcgt
3069661 cccaccgagt gttggattgg ccttcattac cgcgtccatc gcctcgtcga tcagctgacc
3069721 gatgttcttc gccggctcac caccaacggc tggcttgcct tttgtgttct ctgccaagaa
3069781 cttccagcgc gcactcaccg gcacgacgaa tacgccgtaa ccctggtact gctcgggatc
3069841 gtcgatcagg tcttctatct gagactcctc cattccttcg gccgccaact cggcacggat
3069901 tgcctcgcgc cgttcgtcat acgcgtcgga cacgtactta aggaacacca ggccgaggat
3069961 cacgtccttg tattggctgg ccgacagcga cccgcgcagc ttgtcggcgg ccttccagag
3070021 cgtgtctttg agctccttca tcgtcgacgg cgcctgcggc gcctgcttct tcctgggcgg
3070081 cattcccgtt tccttcctat cgatgcgccg cggcgatgcc gggcgtggtg ggccagctcc
3070141 tcgacaacac gaaggtcgca tcgggcgaat cacgctgtcc ctggggccac cacccattcc
3070201 acgggttgcc gtgtgatggc ggcgatgcgt tcgaagtctt ggtcgtagtg catgacgggt
3070261 atgccgtgat gctcggcgac cgccgcaatg atcaagtccg ggatcttgac cgagcggtga
3070321 aatcccttgt cggtcaatgc ttcttggatc tcccatgcac gaacccacac ggtgtcgggg
3070381 gtgttgacgt attcgagcgc gtcacgccgg taggtgccca gtgttcgatg gtcctcgcgg
3070441 gaacgcgccg agactccgaa ctcgagatcg gtaatgccgc accgggccag tagaccgcgt
3070501 tccatcaacg gttccaagcg atgtcggacc gcgggcaagt gcgcgcggta agccgctgat
3070561 ttgtcgagca aatagcgcgt ggtcatgccg tgttctctgg gtggccgtct cgccacattg
3070621 cgttgaccag agcttcgtcc tgggttccgg tggcgttctc ggccatccgg ttcatgagcg
3070681 agcgcgcggc actggctcgc aacgcggccc gcagcgcggc atgcacggtg tctttctttg
3070741 tcgtggtacc cagttccttg gcggcccgag cgagcaggtc gtcatcgatg tcgatcatgg
3070801 tgcgcgtcac acccggagag catactacta atgcatatcc gcgatgcata taacggatgt
3070861 atctcaggcg gggctcaggt gcacgcgggc cggatatcgg tatgcgtgaa gtcatcgcca
3070921 cgaaacagca gcggctcccc ggtgacctgg gccagggcgt agctgtaggt gtcgccgagg
3070981 ttgagacggg ccggatggcc gctgccgcgg ccgtagtcgc gatacgcctg cgcggccacg
3071041 cgggcttggt cggcgtcgac ggcttcgacc tggattccgt agtcgtccag caaacggtcc
3071101 accaatcgag agatctccgg ccggtcccgc cgctgcatga tcgcgcacag ttcgacgtag
3071161 ttgggcgcgg acattcggga gttcggtgac cgctccagcg cctccttgag cacctgcgcg
3071221 cccgattccc cgctcacgat ggcgacgatg gccgacgtat cgacgatcac cggggcagac
3071281 cgctgtcatc gtagaggtcg acctcgtgtc gccgaatcag gcgcttgtcg tcgtcgctga
3071341 gcagcttgtc gaggtcgcgc agggtctgtt cggcggcggc gcgccgggcc tccgcgcgtg
3071401 ccctgtcctc gcggtccaac tccgagaggc ggcgcgcgac ggcgtcctcg acagcagccg
3071461 tctggttggt gccggtgcgt gcggccagtt cccgcaccag cgccacggtg cgctggctct
3071521 tgatattgag gctcatggta gaaggctacc ggccagcggg tagaccatct atcccggaca
3071581 tcaacagcgg aagcagcgca tcgcggcagg atgccaggcg tgcggattca atccgccgct
3071641 cgttgcacag cgcacccagg ttcgcgattg cggccgcgtg tccgggagtc aaccggcgca
3071701 catcgcgcac ccaaacccgc aacagctggg tcggttggat tcgttgccgg cttcccgtca
3071761 tgcccccgac taactgccgc agttctgcca ggacatcggg ttgtcgcagc gccgcccaca
3071821 gggccgaagt gtcgacgccg actggccgca gcacgacgaa ctccgtactc gccagcgcca
3071881 tttccgacgg gaggctggtg atgttccaga ttcgcgggat tcttggattc agtttcggga
3071941 acaacacaca cggctgcgac acgacgagct ttgcgctcct gatcgttcgc ccaccgacgc
3072001 gactgggctg ggcgccgccg tcgaatgccg cgaaactgta atgggcgacg gtgctatcga
3072061 agtgctgcgc atcaagacat gcggttgacc tgctcgccag gctcgacaac ggcacgtatg
3072121 cagagagccg cccgacgatc gcaagcatca acgcctcggc ggcttcgatg acacggtcgt
3072181 tggcggcgat cttgtcgtcg aaggcgccta ggatctcgcc gattcgaggg cggtcgggcg
3072241 cggcgacggc cgataccgaa acgttccgca gaacaccctg actcagcagg ggctgtcccg
3072301 atccggcccg atatcggttg agcccgaaac ccagtagcgc gtaataccaa tatcgggttt
3072361 cctcgggctt cttggcccga cacgccagcg cgttgtcggt cacccacacg tcggaatcgc
3072421 aatagcgcag gctaccgcag tacgagccga cgcggccgac gacgatcagc gggccacgcg
3072481 cgttgtgttg ggcggaatat ccgataaccc cgtttgcacc atagacggga tagcggccgc
3072541 cgggctcgct cgctggcgac gtatggccag acgtatggcc attcgagaag tcgagatggt
3072601 cccctagcct taccttttcg actttctcga cgcggctcat ccgttagtcc gcttggtggc
3072661 cgcgcacagt tccccagcca gatcaccccg ggtggacacg gcgatccccc ccaatcccag
3072721 ccacgacgcc atcgacgcca gctcgccggc caacccctcg gcaaccgtga ccggcggtat
3072781 gtcgagttcg ccaagcacgc ccgccacggg caagctgtcc gcggcgcggt cggttttgcg
3072841 gtccacccgc gcaaccgggt gtccgtcaag gggccgcacg taatacaagt gccggcgttt
3072901 ggccgccact gccgccgaat ccagctgccg cacttggatt cgcgagatca gccgcttgcg
3072961 gtcggcaccg gcgatcgggc cggccgaccc gggttcggcg acgcctccta cgacgacggc
3073021 cgcccggcgg tcccacgcag cagtcgcggc gctcatgagc gcgcgccgcg acgatgcagt
3073081 gggggtacca cccgcttgcg ggggacgaag cgatgaggag aagcggcgct catgagcggt
3073141 ggtagctgta caaccggtac cgcaacccgg accggctgaa gcgccactcc cccgtctcgc
3073201 cccgccatgt ctcgtccagc acgggggcca gcgcgtcacc ggcttcgcgc ggcaggccga
3073261 tgtcgacctc ggtaacctca catctggtcg cgtacggcag cgccagcgca tagacttgtc
3073321 cgcctccgat cacccacgtc tccgggctgg tcagcgcctc ctcgagtgaa ccgacaacct
3073381 cagccccgct ggccataaag tcagcttggc ggctcagtac gacatttcgc cggccgggca
3073441 gcggccggac tttagccggc agcgaatccc atgtgcgccg gcccatcacg atcgtgtgcc
3073501 ccatggtgat ctcccggaaa tgcgcctggt cctcgggcaa gcgccagggg atgtcgccgc
3073561 cgcggccgat gacacccgat gtcgcttgag cccagatcag ccccaccatc gtcacacgcg
3073621 tcactccttg attccggctt gaaggctgtc cgagccgact tcattgtcgt cggcgcgcct
3073681 cataccgcga ctggagcttt gatcgccgga tgcggatcgt agttcttcac aacgatgtct
3073741 tcataggtgt actcgaagat tgaatcccgg tcggctagaa gtagtttcgg atatggccgc
3073801 ggctcgcggc tgagctgcag ccgtacttgc tcgacgtgat tgtcgtagat gtggcagtcg
3073861 ccaccggtcc agatgaactc gccgaccgac aagccggcct gggcggccat catgtgggtg
3073921 agcaacgcat agctggcgat gttgaacggc acacccagaa acaggtcggc gctgcgttgg
3073981 tagagctgac agctcagccg gccatcggcg acgtagaact ggaagaacgc atgacagggc
3074041 ggcagcgcca tccgctcgat ttcgccgacg ttccaggccg acacgatgat gcgccgggaa
3074101 tcgggatcgg tgcgcagcaa atccagcgcc gcgctgatct ggtcgatgtg ctcaccggat
3074161 ggagccggcc acgatcgcca ttgtacaccg tagatcggcc cgagttcgcc tgtatcactt
3074221 gcccattcgt cccagatggt gactccgtgc tcgtgcagcc aaccgatatt ggaatcgccg
3074281 cgcaaaaacc acagcagctc gtaggctacc gatttgaaat ggactttctt ggtagtgagc
3074341 agcgggaaac cggccgacaa atcatagcgc atctgctggc cgaacaggct gcgggttccg
3074401 gtgccggtgc ggtcggattt gggcgtaccc gtttcgagca cgaagcgcag caggtcctcg
3074461 tatggcgtca cgattgacac gcggtcagcc tagcggcgat cgcaagcgcg gcgaagccgc
3074521 cgcagcgact cgccgccaaa caaacccagc gggcgatcgc aagcgcggcg aagccgggca
3074581 cagcgagtcg acgggaatac acccagatcc gcgccacagg agtacaacgg aggccatgcc
3074641 gaaaaccacc gacaccgccg ctactcctga cggcacctgc gccgtgcgtc tgttcactcc
3074701 cgatggtccg ggccgctggc ccggtgtggt gatgtttcct gacgccggcg gcgttcggga
3074761 caccttcgac cggatggccg ccaagctagc cggattcggt tacgtggttc tgcttcccga
3074821 cgtgtactac cgcgaaggcg actgggctcc attcgatatg aagaccgcgt tcggcgatcc
3074881 gcaagaacgc gcacggatca tgtttatgat tggcacccta acgcccgacc gggtaacccg
3074941 tgatgccgat gcgcttctca actacctggc cagccgcccg gaggtgatcg gggaccgctt
3075001 cggtgtctgc ggctactgca tgggcgggcg aatgtcggtg gtggtggccg gccgcctgcc
3075061 ggatcgtgtc gccgccgcgg cagctttcca ccccggcggt ttggtggcca acagcccgga
3075121 cagcccgcac ttgctggccg accggatcag cgccaccgtc tacatcggcg gcgcggagaa
3075181 cgacccgtcg ttcaccgccg accacgccga gaaactcgac aaagcgttca gcgcggccgg
3075241 cgtgccgcac cgcatcgagt gctacccggc cgcccacggg ttcgcggtcc cggacaatcc
3075301 gtcttatgac gccgcagccg acgaacgcca ttgggcagca atgacagaga ccttcggcgc
3075361 agcgctcaac tagccccgcc aagcagacgc agaatcgcat taatcgcgcc cggtttgtgc
3075421 gattctgcgt ctgcttggca gcacctcagg cgccgcgacg tcgatcccga tgatgattca
3075481 gccgacgccg gtccgcggtg cgccccgcga gctacgcgtc gagttgcgtc cgcggcagtg
3075541 cgtggacgca ctttccacgg ggcaaaggcg cccctacacc ggcgcggtca atgctcagtg
3075601 ctgggtgcgg cccggaatcc cagcgcgttg ccgagcagta gaccgccgtc gatgatcatg
3075661 gtttcgccgg tgatccagct tgcggcatcc gaaaccagga acgcgaccgc gctcgctatg
3075721 tcggccggct ccccgattcg tccgagcgca atggtcgccg ccaacggatc ctcgtggtcc
3075781 ttccacagcg cctcggcaag cctggtgcga accaccccgg gacagatcgc attcacccgg
3075841 atgcgcggtg aaagctccag cgccagctgc ttggtgacgt ggatcagcgc ggctttggtc
3075901 gcgttgtaca tgcccatggc cggggactgg tgcatcccgc cgatggaggc ggtgttgacc
3075961 accgcgccgc cgtgctcgcc catccacgcc gtcacgacga gcgaggtcca catcagcggt
3076021 gcccacaggt tgacgtcgaa gatcttggcg aagcgggcgt ggtcctgctc gagcagcgga
3076081 ccgtaagccg ggttggttcc ggcgttgttg atcaggatgt caacgctgcc gaagcgctcg
3076141 agggtgaggt ccacacaacg ccgggcggca tcctcgtcga ccgcgtgtgc accaacgccc
3076201 agggcgcggt cgccgacctg tgcagcagcc tcgtcggcag cttcctgcct gcgtgcggtg
3076261 agcaccacat gggcgccggc agctgccagc tgttgggcga tggcaagccc gatgcctcgc
3076321 gatgcgccag taattatggc ggtgcggccg gtcagatcca gtgaggtcat ttggcttgcc
3076381 ttcggttgct gtggtggccg gactccgccg gcggggagcg tcggtagcgc ccccgcaccg
3076441 tatgcgacaa gaatgctagc gaaatcaaac cccacgaaac caccggtagt ggtggtgcta
3076501 tcgcgattgc cgtagcctgc acaacctcac gccagacttg agccactgcg accatctgcg
3076561 gcgtgtcgcg tgcgtggttt aagtgtcgcg aacggcgagg ccttacagcc tcatgattcc
3076621 gaatgattcc gaacggtatc cggcttgaac gtgccccagc tgtggcggat tctgacattt
3076681 ctcggccagc ccggccacgg gcaccctcgt aaccaaccat ttcgccgcta gcgagcccgg
3076741 cgggggcggc tgcgacgcca tggctccggc ggcttgattg acggtccggg cggcgtcggt
3076801 tgcggcccca ccgtcggttg ccgcaccggc cacgcctggc gggtcgctgt gcgggacata
3076861 gccggccggc ccggtcgatg ggccacaggc caatcagacg acgacctgtt tgggcatgac
3076921 gatgggcttg aacccgtacc gaggcccggc ataggcaccg gctcctttgg ccgccccaga
3076981 aatccccgcc atacccggca ttgcggcgac tggcccggct tcctcgggga ccgcccagcc
3077041 cgagccctcc agtgccgtgg taccagacgt catggccgga gcagcggtcg accaaccggc
3077101 cgggaccgac aggccaccga ccgaggacgc ctcgcccaga ctcgccgtca gcgaggcccc
3077161 accaacgccc actggcgtca ccgtgtgcgc caaaccagct gctgccgcgg cagctggaac
3077221 ggcatcggcg gctgcggtca cggttgccgg gtttagggca gcaaaggcgt gtccgaggaa
3077281 taccgcgttg gggatggtgg ccatgacgaa ccaggcggtg gtgttgaccg cgccgttgat
3077341 cgcgttctga acaaacgtga taccgagcag ctcctcaatg tcctgaatga ttccgcctaa
3077401 tcccgccgcg tcggccgccg atgtcagggg cgaagcgaac cccattaccg cgttcggcag
3077461 gttgctgatc agcgatccca gccccacctg ttggaccgtg ctggcggcag cggcatggct
3077521 gaccgcggcg gcctgaccgg ccagcccggc catgttggcg gtctgggagg gcgtgatcaa
3077581 cgggttcaac ctccccgccg ccgccgagga ggccgcgtaa ccgtacatcg ccagtgcgtc
3077641 ttgagcccac atttcgccgt agtgagcctc ggtcgccatg atcgccggtg tgttttgacc
3077701 caggacgttg gtcgccacca gtgccgcgag cagagccctg ttggcagcga cctccgccgg
3077761 cggaaccgtc atggcgaacg ccgcctcaaa ggcggccgcc gacgccatgg cctgtgcagc
3077821 cgcatgggcc gccgattcag cggtgtaggt caaccaggcc aaataaggct gggcagcaac
3077881 gaccatcgac atcgacgccg gacccagcca ctgttcggta gtcaactgca tgatcaccga
3077941 ctcgacggac gatgctgtag tgctcaactc gacggccagg ccgttccacg tcgccccggc
3078001 ggccatcagg ggtgctgcgc cggcaccggc gtacattcgt gtggagttga tttccggggg
3078061 taaagctcca aaatccattt tccctatccc tctattgatc tctattgatc gaaattcgct
3078121 acttctcaag tgcgggcaac cgcgtcgagg ccgcccccta taccgccggc ttgggcacga
3078181 cgatgggttt ggcgccgtag cgtggcgcac cgaagcccgc gctgctgcgc gtcgccgagg
3078241 ccaaccccgg catcccggga atgaccgtcc ccgcggcacc atgcggtgcc gcggtggtcc
3078301 agccagcgcc ctgcagtgtg ctggtgctcg ataccaggtt ggcctgtccc gcccagctgg
3078361 gcggcaccga caatgcgccg attgacgacg cccgactaag gccggcggct agcggagccg
3078421 cacccagacc ggccgcgatc ggcgcctcgc cgacggccgc ctccgccgcc cccagctccg
3078481 ataggcccgc gccctccaag ccctcctcga gggcggcttc ctcggcagcc ggaagaagac
3078541 caccgctggc cagccctagc aagtccgacg cggcggaggc ccagttccca gccccaatgt
3078601 tgaagatatt ggcaatatct gaaatccagg agggcacctt cccgggcgtg gaacccaaga
3078661 tgctcgcgat acccgacaac ggcgaagcgg ccgcggatga gttggcggcc tcggtggccg
3078721 cataggtgcc agcgctgacc cccagggtct tcacaaacag gtcgtatacc gcagctgctt
3078781 cagcactgac ctgctggtag agagtgccgt acgcggtgaa caacggcgcc tgtagcactg
3078841 atatctcatc agcggcggcg ggaatcacgc ccgtggtggt cggggcggcc gcggccgcgt
3078901 tctgggcgac catcgccgag ccgatggtct cgagcttgcc ggccgcagcc gccaactctt
3078961 caggctgtgt cgtcaggaat gacatcgatt gctcctcata tgactaagcc agcagggcta
3079021 gaaacctgtg aattatctga tcagtccctg ccgaatagct gatcaggtcc tgtgtttaga
3079081 taaggctaac gatccacacc tccgcaagcc cgatcaaaag gcgcaagcgc agaattcatt
3079141 tacggcttat ttacgccggc accggcagtc ttaacacgat ccttttgagc gtggcacctg
3079201 accgctcgcc gcagcagcga aatgaaacac gcgccgcggg agggttagcg caatgtggcc
3079261 gcggcggcgc gctggtcggc cgcgtgcgct tgtctcggtg tctccagatc agaagaggcc
3079321 gtgcttgggc ataacaatcg gcttgactcc gtaccgtggt ccggagtcgg caccaacact
3079381 gttggcggct acgaccattc caggggcagg cggcatcact gcgatcgggc cgtcctcctc
3079441 gggaactgcc cagcctgtgc catccaaggc cgcgccggct gccgtcgccg gcgctgcagt
3079501 agaccagctt gccggcaccg acaggcgacc aaccacggac gcattgccca aatcggcggt
3079561 cagcgctgtt ccgccgacgc ccgctggggc aaccgcgtgt gccaccgcgg ctgccgcgcc
3079621 gccacctgga gcggctccgc caacggttcc catagcatcg gcaagaagcg tcatattgcc
3079681 aatggcggcc gtggcaaagt ctgccacgcc acccaggccg tgaaacgcgg attctacgaa
3079741 cagcggaaca tcgagattga ggaactgcct gaccgcctcc aacccggtat cggccgcgga
3079801 catcaccggg gaggcgaagc tcaggacagc gtcggcgacg tcgctgatca ggtggctcag
3079861 acccacctgg cgcgcgaaag cggatgcgcc ggcttggcca acagcggcgg cttggtgtgc
3079921 gagcccggcc ggattggtga tgtgcgacgg cctggtcagc gggttcagtc ttgcggcgac
3079981 cgcggatgcg gccgcatagc cgtacatggc cgaagcgtct tgggcccaca tttcgccata
3080041 gcgtgcctcg gtagccgcga tggccgacac gttttgccca aggatgttgg tcgctgtcag
3080101 ttcagccaac agggctctgt tggcaaccac ctcggccggg ggcactgtca gcgcaaacgc
3080161 cgtttcaaag gcggccgcag acgccatggc ctgtgccgcc gcgagcgccg aggattcagc
3080221 ggtgcaggtc aaccagacca aatagggctg caccgcggcg gccatcgaca acgatgcggg
3080281 acccatccag tgctcggtgc tcagccgcgt gatgaccgac ccgacggagg acgcagctgt
3080341 gctcacctcg acagctatgc cgttccacgc agccgcagcc gccagcaggt ctgccgcgcc
3080401 cgcgccgcca tacatgcgcg cagaattgac ctccggaggt agagctccaa aatccactga
3080461 ggcgttccgt ttctggtcga gtgcagtggt ggccggtgct ccgtctgagg cagccattat
3080521 tccatcaagg tcagcgccag cgtaggcacc acgctcgcca cggcgtcgat ggcgcccaaa
3080581 tcatcccatt aactgcgcag cgacggttgc tccgaggttc cagcacgcct cgatatcggc
3080641 cttgctcggc ttgcccatca ccactacagt ctcagcggct tgcacccaac ccaggccggt
3080701 tgtgatggcg tcgacggctc gctcggctcc ctcggtgccc tcgttgccgt gaatgtacgc
3080761 gccgaacgaa cgcccacggg tggtgtccag gcagaggtaa tagcagacat cgaaggcatg
3080821 cttgagagca ccactgatgt accccagatt ggctggggta cccagcagat agccgtcagc
3080881 ctccagcatc tcgatcggcg aaaccgtcag ggcgggtcgt ctcaccacct cgacgccctc
3080941 aatctcggga tcggtcgcgc cggacaccac cgcctcaaac atctcctgca tgtgcggaga
3081001 cggcgtgtgg tgcacgatca gcaagcgccg caccgcagga ccctgtcact aaaagtgggg
3081061 taatcgacca aagcgtgcag aagcgctccg gacaggtagc ccaaggccgg caacgtggtc
3081121 atctggcccc cggcctagcg cgcccctcta gctgtagggc cgtcttcatc gcttcccgcg
3081181 cgcggcgccg atcccccgcg tagtcgtagg cgcgcgccag tcggtaccag cggcgccagt
3081241 cgtcggcgtc gtcttcgagc tcggtgcgca cggcagcgaa caacgcatcg gccgcgtctc
3081301 gctgaatgcg gccagaagcc cggcggggca gcgcgctggc gtcgatgtcc agtccgtctt
3081361 cggcgatcag acgggccagc cgctgatacg cgaatccggc ccgcagcgtg gcaatcatgg
3081421 cccacagccc aatgaccggc aggatcagca gcgccagccc cagcccggca gccgcggcgc
3081481 ggcccgaacc gatcattgcg acggcgacac gcccgagcat aaccaggtac gccaccatcg
3081541 ccacgcacat gaacgcgatt atcaactgga catacagggt gcgcctggtc atcacagtgt
3081601 cggtcagtgc agatcgagta ggggctcaag acctacggtg agaccagggc gttcggcgat
3081661 gcggcgcacc gccaacagca caccgggcac aaacgatgtg cgatcgaggc tatcgtggcg
3081721 gatggtcaga gtctccccct cggtcccgaa cagcacctcc tggtgggcga ccagtccggc
3081781 cagccgcacc gcgtgcaccg gtatgccgtc gacgtcggca ccacgcgcgc ccggcaggct
3081841 ggtactggtg gcatcgggat tgggcggcaa gccttttcgg gcctcggcga tcagcttcgc
3081901 ggtacgcgcg gccgtgcctg acggcgcgtc agccttgtgc ggatgatgca gctcaatgac
3081961 ctcggccgag tcgaaaaacc gtgcggcctg cttggcgaaa tgcatggaca gcaccgctcc
3082021 gatcgcgaag tttggcgcta tcaacaccga tgtgttgggt tttgcgacga gccacgattc
3082081 gacttgttga aaccgctcgg cggtgaaccc cgtggtaccg accacggcgt gaattccgtt
3082141 gtcgatgagg aactccagat tgcccatcac cacgtccggg tgggtgaagt cgatgacgac
3082201 ctcggtgtta ccgtccgtta gcaggctcag cggatcgccg gcatccagct cggcggatag
3082261 ggtcaggtcg tcggcggccg ccaccgcccg caccatcgtc gctccgacct tgcctttggc
3082321 tccaaggacg cctacccgca tggccttcac cctagaccgg gccgtcctcg aggccaacga
3082381 ccgcggctgc accaaacccg gcgtgcgccg tgaggcgctt gttgatcgag tggaggtgaa
3082441 agacctgcac ggtagttctg tcgcagctgt ctgaaccacc ccatcggcag attccgtgaa
3082501 gagccagata cggtgaaagt cgcacgtccg gttcgaaggg cggccacggg aaacggaccc
3082561 gcagcaacgc gggcaccgca cccatggtcg acccaactgc cacgcacccg gtgaccggtg
3082621 cgaagtccac catatcgacc agtgggcaac cggcacatcc caccacaggt tggtcggaaa
3082681 cggctggtgc acaacgaagc tccccaacgg ccaaaccgca gggatcccgc caccccacct
3082741 cgaccgcggt gcccacacca aacaactacg cgctgaccgc cgcgactgcg cccacgacct
3082801 atctaggctt taatgatccg aggcgtcagc agcgaaggtg ctcatgtgaa acccagcaat
3082861 atcaggattc gtgcagccaa accgatcgat ttcccgaagg tggcggcgat gcactatccg
3082921 gtttggcgac aatcctggac cggaatcctc gacccgtacc tactcgacat gatcggttcg
3082981 ccgaagctgt gggtcgagga gtcttacccg caaagcctga aacgcggcgg ctggagtatg
3083041 tggatcgccg agtctggcgg tcagccaata ggtatgacga tgttcgggcc cgacattgct
3083101 catcctgatc gcattcaaat cgacgctttg tatgtagccg agaacagtca acgtcacggc
3083161 attggcgggc gcctcctcaa cagggccctg cactcacatc cgtcagccga catgattttg
3083221 tggtgcgccg agaagaacag caaggcacgc ggcttctacg agaagaagga ctttcacatt
3083281 gacggccgca ctttcacgtg gaaaccactg tcaggtgtga acgtgcccca tgtgggctac
3083341 cggctttatc gatccgcccc gcccgggtaa gcatcaggcg tcgataacca cccgaccgct
3083401 cacggcccgc gacacacaga ccagcatctc gttatcgcct tcgatgatgc ggccgcggcg
3083461 gtcgacctgc ccggcaagga ctctcacctt gcaggtcccg cagaagccct gctggcagga
3083521 gtatgccgtc gtcgggtccc agtcgagcat gacgtccagc gccgaccggt tcgccggaac
3083581 tcggagcact cgcctcgacc gtgcgagctc cagctcgaac ggaactccgt cgacaaccgg
3083641 cggcgggctg aatcgctcgt aatgcagcgg cgcgtcggcg tgttgattgc gggccacgcg
3083701 caccgcttct aacatcccgg gcggcccgca cacgtaaacg gccgtcgtcg gccctgcgcc
3083761 ggccaacagt tcatcgacag acgcaaaacg accgtgctcg tcgtcggccc acaccgtgac
3083821 ccggccgggt gccaccgcca ctacctcgtc caggaacggc atgtactccc gaccgcgacc
3083881 ggcatagatt gcgcgccagt cgattccgcg ctgttcggcg gcccggatca tcggcaggat
3083941 gggcgtcacc ccgataccgc cgatcacgaa aagcacgtca cgctcggcca gaccgagatg
3084001 gaaggcgttg cggggacctt cgaactcgca cgtgtcacct acgtcgaagg cctcgtgcat
3084061 ctcgatcgaa ccgccgccgc cgtccgcgat tctgcgaatg gcgatccggt agtccgtacg
3084121 ccgtccgggc acaccgcaca acgagtactg tcggcgccgc cccgagggca gctgcacgtc
3084181 gatgtgccca ccgggcgacc aggccgggag caatccgcca ccggggtcag ccaacgtcaa
3084241 cgccaccacg tcgggagcga ccagctcgcg cttggtaacc accgcgggat tcgtgcgccg
3084301 caccggctgc acccgcgacg gttcccaccg cgaggccgcg cccaatcctc ccaataacgc
3084361 tcgtacaccc cacagcgctg tgaagaagcg gtcccggctg cggcgaccgt aaaggtcggc
3084421 gggcctactg gcccagctgg tctctggcac ggtgcgctcc gccattccta cggatcgtca
3084481 ccgatcagtg cgacgctcgc gcggcgggcg agacggccag gtagtccacg gccgccccca
3084541 gcccgcccag ctgggacggg tgaaaacccg gcttgtagta gtgccccacg acccgaagca
3084601 gccgcggcag cccgggcacc aaaccacggc gtgcggcctt gaaatagtcc cgccagcgcg
3084661 gctttgtccc cggtggcagg tacggatcca ccgaatacat gaaccgcact ccgcgaatcc
3084721 acagcagcaa catcaccggg gtaacggtca gctgggcacg cacctgccgc cagtaaccgg
3084781 cgcgcaagtg cttcatggtg tcgaaggcca cggctttgtg ctcgacttct tctgcaccgt
3084841 gccaccgcag catgtccagc atcacggggt ctgcaccgac ggcatcgagc tgcggggaat
3084901 tcaggatcca ctcgcccatg acggcggtgt agtgctcaat tgccgcgatg aacgaaacct
3084961 gctctagcaa ccagctgtac tgtcgtcgcg ggctccgccg aggactctcc cccagcagct
3085021 tttcgaacag ccacctgatc tggttggtaa acgctgtcac gtcgacaccc tgggcatcga
3085081 agtggtcaac cacgccggag tgcgcctggg aatgcatcgc ctcctgaccg atgaatcctt
3085141 gcacgtccag cctcagttga tcgtccttga tcagcggcag cgtcttcttg aagaccctga
3085201 cgaagaactc ctcgccggcc ggcagcagca tatgcagaac gttgagaacg tgggtggcca
3085261 tcggctcgtt gggcacatag tgaaatggca ggtttgtcca gtcgaattcg acatctcgcg
3085321 gctcgaggac gagacgttcg tggtcggcgg cgcgcgactc tgacgagtgc ggacccgtcg
3085381 cccggtcatc gacgctgacc attgctgccc cctcagaaaa cgtagccacg gcgtttacat
3085441 aaatgcccga catgtcgccc cagtagacat cacgtgttgg caagtatagt tgcgcgtacc
3085501 cgaggggtga agaacctgct cgccagcctg gcgccgaatg cacctcgacg ttcaccgcgc
3085561 ctcggcagcc gacgatgtcg gcttcaccgt gtcgaattcg tcgcctcgcc ctcgtcggcc
3085621 tactcgcaac tggtggcatc agtaatgcca ttgcgcagca acgcacttgc tacggcacgc
3085681 gactcgccat cagtgtcccg ccagcacttt cgctacccgg cctcagctcg gtccttgaga
3085741 cgctgcaggg tgcgtcgaat gtgctcggtg tttacgctcg cccgatcctt gacgccggtg
3085801 gccatccggg caactgcgcg gaaccagctg ggccgccggt cccaggtgct ctccgtaacc
3085861 cgacagccgt gttcggtagc gacgatgcca tattgccagc gtgaaatcgg aataatgccg
3085921 gaccgtacat cgaaagcgaa aacccgaccg ggatcggcgt cggtaacggt gcacgtcgtg
3085981 gtccagcgcc gtccaccgtt ttcgttgcga ccgacaaaca ccgctccctt gcgaacatcg
3086041 tcgcctttgc gcaactgcat cgccaccact tcctcggcca gcgaggccag tgtcggcaga
3086101 tcagtgatca gcccgtatac caggtcggga ttggcgtcga tctcaacggt gaccgtcaca
3086161 gaaggcccat cagggtctgg catcccgcga tcatagcccg ctgggcgggc cgctctagat
3086221 gggcgccgcc ccgcgcagat gctcgaagat cagggacgtc tgggtacctg cgacgtcggc
3086281 gtcggcattg aggttttcga ccacgaacga acgcaggtcc tcggtgtcgc gagcggcgac
3086341 gtgcaagatg aaatcgtcgg cgccggccag aaagtagaca tccatcacct gccgtttgcg
3086401 gcggatctgc tggatgaagc tgcggatttt cccgcgagcg gacgactgca agttgaccga
3086461 gatcatcgcc tgcaacggca aacccaccgc gaccgggtcg atgtcggtgt agaacccccg
3086521 gatcacgccg aggtccacca accgccgaac ccggccgtga cacgtcgacg gcgctatccc
3086581 gacagtgtcc gctaacgcgt tgttgggcat tctggcatcg ccatgcagca agctcaggat
3086641 tctgcggtcc acctcatcaa gttcagcggg tcgaacatcc ttcgacgagg cagcccggcg
3086701 agtcttgtgt tccgttgaat tatcacgcat atggcctcga aaaagaatta tcatcagcaa
3086761 tcttgcagat taatcgaact ttcttcatac tgaagcgtac agtatcgaga ggggtaatca
3086821 tgcgcgtcgg tattccgacc gagaccaaaa acaacgaatt ccgggtggcc atcaccccgg
3086881 ccggcgtcgc ggaactaacc cgtcgtggcc atgaggtgct catccaggca ggtgccggag
3086941 agggctcggc tatcaccgac gcggatttca aggcggcagg cgcgcaactg gtcggcaccg
3087001 ccgaccaggt gtgggccgac gctgatttat tgctcaaggt caaagaaccg atagcggcgg
3087061 aatacggccg cctgcgacac gggcagatct tgttcacgtt cttgcatttg gccgcgtcac
3087121 gtgcttgcac cgatgcgttg ttggattccg gcaccacgtc aattgcctac gagaccgtcc
3087181 agaccgccga cggcgcacta cccctgcttg ccccgatgag cgaagtcgcc ggtcgactcg
3087241 ccgcccaggt tggcgcttac cacctgatgc gaacccaagg gggccgcggt gtgctgatgg
3087301 gcggggtgcc cggcgtcgaa ccggccgacg tcgtggtgat cggcgccggc accgccggct
3087361 acaacgcagc ccgcatcgcc aacggcatgg gcgcgaccgt tacggttcta gacatcaaca
3087421 tcgacaaact tcggcaactc gacgccgagt tctgcggccg gatccacact cgctactcat
3087481 cggcctacga gctcgagggt gccgtcaaac gtgccgacct ggtgattggg gccgtcctgg
3087541 tgccaggcgc caaggcaccc aaattagtct cgaattcact tgtcgcgcat atgaaaccag
3087601 gtgcggtact ggtggatata gccatcgacc agggcggctg tttcgaaggc tcacgaccga
3087661 ccacctacga ccacccgacg ttcgccgtgc acgacacgct gttttactgc gtggcgaaca
3087721 tgcccgcctc ggtgccgaag acgtcgacct acgcgctgac caacgcgacg atgccgtatg
3087781 tgctcgagct tgccgaccat ggctggcggg cggcgtgccg gtcgaatccg gcactagcca
3087841 aaggtctttc gacgcacgaa ggggcgttac tgtccgaacg ggtggccacc gacctggggg
3087901 tgccgttcac cgagcccgcc agcgtgctgg cctgactctc ggccgctcgt tacgccgagc
3087961 acacgtcggg agtaagggaa gcgatgatgt cggccgcggg tcccggccgg gtcttccggt
3088021 gcgccgatcc cgcccaaagg tttgttccgt gcgggtcgtc cgcctgcacc gccgccgccc
3088081 gtatcggctt cgtcatctgg tggacctccg gataacccag cggcgccacg tggtcgagca
3088141 ggcgagtgaa gttgttggcc agaccgcgcg catacctacc cgagaacgcc cgagtgacca
3088201 gggtggcatc gaactctgga ttcttcagcg cggcacggtg tgcggcattg gtaccggctt
3088261 cgtcggccag cagcaatgcg gtaccaacct gcgcggcgat cgctccgcgg cgcagcacgg
3088321 cggccacgtc ctcagccgtg cccaggccac cggctgcaac cagcggcaca tcatgggcgc
3088381 tgccaatccg atcgaggagt tggtgcagcg actccgtacc gggttccatg tccggcgcga
3088441 acgttccgcg gtgcccgccg gcagccgggc cctggaccac caggctgtcc gcgcccgcgg
3088501 caatggccac accggcctcg tagaccgacg tcacggtgat cgagaccaac agtcccagcg
3088561 cgctcaaccg ctgcacgaca tccggcggcg gcgcgccgaa ggtgaacgac accacctccg
3088621 gacgaacatc ggctaccacc tcgagtttgc gcacccagtc gtcgtcgtca ccatagacgg
3088681 gctggcccac ctcggtgtgg tagtactcgg cgacctcttc gagctcgtcc gcgtaatact
3088741 ccagctgcgc ccagtcggcg acgctgggtt ggggcacaaa cagattggct ccgataggac
3088801 cggtagtggc ggcgcgcgca gcggcgatat cgtcggcgag ccggtccgcg ctcagatagc
3088861 cgccggcgac gaaaccaagc ccgccagcgt tggacaccgc cgcggccaac gccggggtgc
3088921 tcgggccgcc ggccatcggg gcgccgacga tcggcaccgc gatgtcccag aagcccaaca
3088981 ccatcgggct aattcgccga cggcgagcgc cggcacggcg cgagtgagga agcggacatt
3089041 tgagctaccc taccatcgct cgaagttgtt gcggcagtga tcgtttcgat ccgtgtgggc
3089101 caagaacggc agcaccgtag cgcctgctca gcaggtggcg ggccaccgcg ttgacctcct
3089161 ccacggtgac ctgctcgatt tgccgcaagg tgtgttcgat gctgcggtgc ttgccgtagt
3089221 tcaactcgct gcggccgagc cggctcatcc gggagctgga atcctccagc cctagcacca
3089281 gcccaccccg cagcgatccc ttggcgatgc cgcattccgc ctcggtgatg ccgtcgcgtg
3089341 ccacgctttc cagcacatcg gcggtcaccc gcatcacgtc ggcgaagcgt tcgggcaggc
3089401 aggccgcgta caccgaaagc gcgccgctgt cggcgaagag atccagcgcg gagtagaccg
3089461 agtaggccag cccgcgggtc tcgcggacct cctggaacag ccgggaactc aagccaccgc
3089521 ccagcgcggt gtgcagcacc gacagtgccc aacgatgctc ccagccgcgc ccgggtgtgc
3089581 ggatgcccag cgacacatgc gtctgttcgg cgtcgcggct aaccagtgtc aaccgggggc
3089641 tgccgttgac ccggccggta cccttgcgcg gcgcaactgg ccgtctcccc cggaccaacc
3089701 gggacccgaa gtgctcgcgg accaacgcaa ccagcccgtc gtgatccaca ttgccggcgg
3089761 ccgcgacgac catccgctcc ggggtatagc gccgcaggtg aaacgattgc agttgagccc
3089821 gcgtcatcac cgacacggat tgcgcgctgc cgatcaccgg gcgaccgacc gggtggtcgc
3089881 cgaacaacgc cgccaggaac atgtccgcca aggcgtcctc ggggtcgtcg tcgcgcatcg
3089941 cgatctcctc gaggacgacg tcacgttcca cctcgacatc gtcggcggca cagcggccgt
3090001 tgagcaccac atcggcgacc aggtcgacgg ccaacggcaa gtcgctgccg agcacgtggg
3090061 cgtagtagca ggtgtgctcc ttggcggtga atgcgttcag ttccccgccc accgcgtcca
3090121 tcgcctgcgc aatgtccacg gcagagcggg tgggcgtcga cttgaacagc aaatgctcaa
3090181 ggaagtgcgc cgccccggcc accgtggcgc cttcgtcgcg cgatccgacg ccgacccaca
3090241 ccccgaccga cgcggagtgc accgcgggca ggaattcggt gaccactcgc agcccgcccg
3090301 gcagggtggt gcgccgcggc gccagcgccg ccgcggggtc agctggtgac cgtcgcggca
3090361 tcggtagcgg cggcggtgct gtcctcgtcg gcgaccagga tcagggagat cttgccccgt
3090421 ttgtcgatgt cggcgatctc cacccgcagc ttgtcaccga cattgacaac gtcctcgacc
3090481 ttcgcgatgc gcttgccctt gccgagtttg gaaatgtgca ccagaccgtc gcggccaggc
3090541 agcaacgata caaaggcacc gaaatcggtg gtcttgacca cggttccgag gaaccgttcg
3090601 cccaccgtcg gcagctgcgg gttggcgatg gcgttgatct tgtcgatcgc ggcctgtgcc
3090661 gatggcccgt cggtggcgcc gacgaacacg gtgccgtcgt cttcgatgga gatctgcgcg
3090721 ccggtctcct cggtgatggc gttgatgacc ttgcccttgg gtccgatgac ctccccgatc
3090781 ttgtccaccg gaaccttgat ggtggtcacc cgcggggcgt agggactcat ttcgtcgggt
3090841 ctatcgatgg cctcagccat cacctccaag atcgtgaggc gggcgtcctt ggcctgctcg
3090901 agtgctccgg caagcacctg cgaagggatc ccgtcgagct tggtgtccag ctgcagcgcg
3090961 gtgacgaagt ccttggtccc ggcgaccttg aagtccatgt caccgaacgc gtcttcggcg
3091021 ccgaggatgt cggtgagggt gacgaagcga cgctccacaa cgccgtcgac cgccccttct
3091081 acttgaatgt cgtcggagac caggcccatc gcgatgccgg ccaccggcgc cttgagcggc
3091141 accccggcgt tgagcagcgc cagcgtcgac gcgcacaccg accccatcga ggtcgacccg
3091201 ttggagccca gagcctccga cacctggcga atggcatacg ggaattcctc gacgctcggc
3091261 aacaccggca ccagggcccg ctcggccagt gcgccgtgcc cgatctcacg ccgcttgggc
3091321 gaaccgaccc gaccggtctc gccggtggag aacggcggga agttgtagtg gtgcatgtac
3091381 cgcttcgatg tctccggccc caacgagtcg atctgctggg ccatcttgat catgtcgagt
3091441 gtggtcacac ccaggatctg ggtttcgccg cgttcgaaca gcgcgctgcc gtgcgcgcgc
3091501 ggaaccacgg ccacctcggc cgacaatgcg cgaatgtcgg tgatgccgcg gccgtcgata
3091561 cggaaatggt cggtgaggat gcgctgccga accagctttt tggtcagggc acgcaacgcg
3091621 gcgccgacct ccttttcgcg accctcgtag gtgtcggcga gccgctgcac aacctgggtc
3091681 ttgatttcgt cgatgcgctg gtcgcgctcg gctttaccgc cgatggtcaa cgcggcggcc
3091741 aactcgtcgg tggccaccga ggacaccgag tagtacacgt cttcgccgta gtcagggaac
3091801 accgggaagt cgacggtcgg tttgcccgac tttccagcgg catcggcaag ctcctgctgc
3091861 gcggtgcaca gcgcggcgat aaacggcttg gccgcctcca ggcccgcggc caccacgctt
3091921 tccgtcggcg cttgggcacc accttcgacg agctcgacga cgttttcggt ggcctcggct
3091981 tcgaccatca tgatggcaac atcaccctcg acgatccggc cggccacgac catgtcgaac
3092041 acggcgcgct cgatctggtc gacggtgggg aagccgaccc aggtgccgtc gatgagcgcc
3092101 acccgcacac cgccgatggg cccggagaac ggcagaccgc ccagctgggt ggacgccgac
3092161 gccgcgttga tcgccaatac gtcgtagaga tcgcccggat ccaggctgag aatcgtcacc
3092221 acgatttgga tctcgttgcg cagcccgtcg acaaacgacg ggcgcagcgg gcggtcgatg
3092281 agccggcagg tcaggatcgc gtcggtggag ggtcggccct cgcgacggaa gaacgaaccg
3092341 gggatgcggc cggccgcata catgcgctcc tcgacgtcga ccgtgagggg gaagaagtcg
3092401 aagtgttctt tggggttctt gctggcggtg gtcgccgaca gcagcatgtt gtcgtcgtcg
3092461 aggtaggcga ccaccgcgcc ggcggcctgc aaggccaatc ggccggtctc gaagcggatg
3092521 gtccgggtgc caaagctccc gttgtcgatg gtggcggtcg tctcgaacac gccttcgtca
3092581 atttcagcgg cagacatgac gtccgtgcgg cctctctgga ttattgagct gtttcgcgtc
3092641 gtcacgcgca atccagcggg ttcgccgaac cccgagagct tcccaggaga aaaggtctga
3092701 atgcggctac ggccatcgat cgaagcggcc gacctgcccc agatccggag agcccggcag
3092761 ccactaccga ggaccgcccg atacaggccg ggggtgctcc cttggatatg catagtgact
3092821 cgctggaacg gcacacgcgg ttctgcgcgt accgcaccat ttgctgggcc gaaccggccc
3092881 agaacgttct cactctacac gggcgaccgg cggcatttgc gtagaactcg ctttgccgag
3092941 ctaccccgcc tcagctccgc gggccgccgg tgacatcctc gacgcacacc gcgaaccgtc
3093001 gctgagtgta gacgtagccc acgccgctgg cgcactggtc gacgctgacg ggagagtcga
3093061 ggtctttcag gatctgggtg gcccgctgcc ggtgcggcac cgaggcgtcg tcgcagtcca
3093121 cccggaacgg gtcggtgttg tgggtagggt cgacgctcat acaaccgcca atcacccaat
3093181 cgatgtccag gcaaatggtg ttggttgagc cgttgaacgc attgcgcatc gaataggtgg
3093241 agtcgacgtc cgccgggcat tccgcgtggt cctcctgcac gacggcaacg accttgaagt
3093301 tggacgccgg gctcccgcac tccgccttag tggcctgcgg ccggtcgggc gtgccggcga
3093361 gtttgacgca gtcccccacc ttgagttcgg cgacgttggt cgctgacgaa caccccgtcg
3093421 ccacgacgaa caaggccgtg gtcgcggccg cgagccaggc gcgcatcgac gccgcgggtc
3093481 agcgacgcag gcccagccgc tcgatgagtg aacgataacg ctccacatcg atctgggaaa
3093541 tgtacttgat cagccggcgc cgccggccca ccagcaacag cagtcctcgc cgcgaatgat
3093601 ggtcgtgctt gtgcaccttg agatgctcgg tgaggtcggc gatgcgtttg gtcagcaacg
3093661 cgatctgtgc ttccggggat ccggtatcgg tctcatgcag gccgtaggag cgcagaatct
3093721 cctttttttg ctcggctgtc agcgccacga aatgtctcca tcaatgggtt cgcgatcatg
3093781 gatatcaggg cacggccacc gcgaaccgca gcacgcaccg atgtcgttgg acagtctagc
3093841 agcgggttga ccgccaaaca caaacgccgc aggtgccagc cgggggtcac gaccgcaaga
3093901 accgtcaacc cgtagacaac aggtcacgtg cccgctcggt atcggcaccc atcgcagcga
3093961 ccagctggcg caccgattcg aacttcttct ggccgcggat acgcccgacg aagtccaagg
3094021 ccacatgttg accgtagagg tcagcggtgg tgtccagcac gaacgcttcg acggtgcggg
3094081 tgcgtccgga gaaggtggga ttggtcccga ccgacaccgc ggcctggtag cgctcacccg
3094141 ggacgaccgt gccggtcacc ggcccatgcc cgagcaccgt gaaccaagcg gcgtacacgc
3094201 cgtcggccgg aatcgccgaa tacatcggcg gcgccacgtt cgcggtggga aagcccagct
3094261 ccgcgccccg cccctcaccg cgtaccacaa ccccctccac gcggtgcggt cggcccagag
3094321 cttccatggc cgccaccatg tcgccggcgt ccacgcagga ccggatgtag gtggaggaga
3094381 acgtcacggt ctcgttgctg tggtgctcgg acaccaacga catcgattcc accgcgaacc
3094441 cgaaccgctc gccagcccga cgcagcgtgt cgacattgcc ggcggccttt ttgccgaagg
3094501 tgaagttctc gccgacgacg acctccacca catgtaggtg ctcgacgagc agctcatgga
3094561 tgaagcgatc cggcgtgagc ttcatgaaat cggtggtgaa cggcatcacc aggaacactt
3094621 cgatgcccaa gtcttgaacg agctccgcgc gtcgggtcag ggtggtcagc tgcgccgggt
3094681 gactgcctgg atagaccacc tccatcgggt gcgggtcgaa cgtcatcagc acggccggta
3094741 caccgcgagc gcggccggcc ttgaccgcgt gcgcgatcag ttcggcgtgc ccgcggtgca
3094801 cgccgtcaaa taccccgatg gtgagcacgc atctgcccca atccgtcggg atctcgtcct
3094861 ggccacgcca gcgctgcacg atcgcaagcc tacggcgcac ggtggtcggc caggcgccag
3094921 attcaccggt gggctctggc cagcggccga tccgggaaca ccatgcacgc ggccgccgga
3094981 cacctggcgc agcacgtccg ggaacgccgg cggcaccgtg gccggtccca gagaattggc
3095041 gcgcgcatac cgaacgattg gtctcaagct ttacgccgac cattgatcag gtgatcaggg
3095101 agtgggtctg atgagtacgt ttagagaatg ccgcagcatg ttcgatgccg cggtgaagag
3095161 ctaccagtcc ggagacctgg ccaatgcccg agcggccttt ggccgcctca cagtcgaaaa
3095221 cccggacatg tccgatggct ggttggggct tctggcctgc ggcgaccatc atcttgatac
3095281 cttggccggt gcccatcaac actccgaagc actgtacagc gaaacccgcc gcgtcggcct
3095341 cacggacggc gaattgtccg ccgtggtcat ggccccgatg tatctggggt tgcgggtgtg
3095401 gtcgcgcgcc acgatcgggc tcgcgtacgc cagcgctcta atcatcgccg accgccacga
3095461 tgaagcggca gcaacgctgg acgacccggt catcacggag gacaccggcg ccgcccaata
3095521 ccgccagttc gtcatggcga cgctgttcca caaaactcgc tcctggtcca accttttgaa
3095581 ggtcaccgaa atttctccgc cgagcggggc caccgatgtc cgtgacgagg tggctgacgc
3095641 ggtggccgcg ctggcctcga ccgctgcggc gagtctgggc caattccagt tcgcgttgga
3095701 gctcgctgag caagtctcga caaccaatcc gcgggtgact gccgatgtga ccctcactag
3095761 ggcgtggtgc ctgcgcgaac tgggtgacga cgacgccgcc agagtggcac ttagcgccac
3095821 gaccaccggt gatgccccca ggacaaacac caccgcggaa caggctggta gcccccaacc
3095881 gaagtttcga catccttacg acgacggccg ggatctcctg gtggctcgcc gccgcccgcc
3095941 ggccggggac ggttggcgca aagcggtaac caaaatgact ttcgggcggg tgaatcccga
3096001 accgagcgcc aagcgcgagc aaaccgacga gctgattcag cgtatctgcg ctccactggc
3096061 cgatgtccat aagttggcgt tcgtctctgc caagggcggc gtaggtaaga ccacgatgac
3096121 ggtgctggtg ggcaacgccg tcgcccggct gcgcggcgat cgggtgatgg ctgtggacgt
3096181 cgatgccgac ctgggcgacc tgtcagcaag gttcagtgag cgcggtggcc cgcagaccaa
3096241 catcgagcat ttcgtgtcat cgcagcacac caagcgctac gcggacgtgc gtgtgcacac
3096301 ggtgatgaac aaagaccggc tggaaatgct tggtgcccag aatgatccgc gatcgacata
3096361 caagtttggc ccggaggact atggggccgc catgcagatc ctggaaaccc actgcaacgt
3096421 catactgctt gattgcggca caccggtcaa cgggccattg ttcagcaata tcctcaacga
3096481 cgtcactggt ctggttgtgg tggcatccga agacgtgcgc ggtgtcgagg gagcgttggt
3096541 cactctggac tggctggggg cgcatggctt tggccggttg cttcagcaca ctgtggttgt
3096601 tctcaacgca atccagaaaa cccggtcact tgtggattgc ggggccgccg aaaaccagtt
3096661 caggaagcgc gttccggatt tctttcggat tccctacgac ccgcatctgg ccacgggttt
3096721 ggcggtcgat ttcagctctc tcaagcgaag gacacgcaac gccgtgctgg atttggccgg
3096781 cggcctggca cagcactatc cggctagccg agtacggccc cgtggcgagg acagttggaa
3096841 aacctggatc gaaacgatgc gtcaggtcgg atgacggttt ggtcgagacc gagttggcgg
3096901 ccatttcccc gactgcgcac cgagcgcgcc gtcacgccgg tatctagact ctctggttgt
3096961 gagggctgac gaggagcctg gcgatcttag cgcggttgcg caggactatc tgaaggtcat
3097021 ctggaccgcc caggagtggt cgcaggacaa ggtcagcacc aagatgctgg ccgagaggat
3097081 cggggtgtcg gccagcacgg cctcggagtc cattcgcaag ctcgccgagc agggcttggt
3097141 cgaccacgag aagtacggcg cggtgacgtt gaccgattcg gggcgacgag ccgcgctggc
3097201 aatggtgcgc cggcaccggc tactggagac attcctggtc aacgagctcg gctaccgctg
3097261 ggacgaggtg cacgacgagg ccgaggtgct cgagcacgcg gtctcggatc gcttgatggc
3097321 ccgcatcgac gccaagctgg ggttcccgca gcgcgatccg cacggtgacc cgatcccggg
3097381 cgccgacggg caagtgccca cgccaccggc tcgtcagctg tgggcgtgcc gcgacggcga
3097441 cacagggacg gtggcccgta tctccgatgc cgacccgcag atgctgcgat actttgccag
3097501 catcgggatc agcctggact cgcggctgcg ggtgctggct cggcgcgagt tcgccggcat
3097561 gatctcggtg gcaatcgact cggccgacgg cgccaccgtc gacttgggga gcccggccgc
3097621 ccaggcaatc tgggtggtga gctgacggct ttggcccgcg agcgtaacgt ggctgcgatt
3097681 ttcggcacgg attttcgcag tccggttacg ctcgcgaagc cggttcgccc agcaggccct
3097741 tggcgatgtg ggttacctgg acctcgttgc tgccggcgta gatcatcagc gacttggcat
3097801 cgcgagccag ctgctccacc cgatattcgg ccatgtagcc gttgccgccg aacagctgga
3097861 cggcctccat cgcgacatcg gtggcggcct ccgaggaata cagcttgatc gccgaggcct
3097921 cggccagcgt cagctgtttg ccggctttga gccgctcgat ggcctgaaat accatgttct
3097981 gcacgttgat ccgcgcaact tccattttcg ccaacttcaa ctggatcagt tggaactgcc
3098041 cgatgttacg gccccacagc gtgcgggtct ttgcgtaatc cacacacagc cggtggcatt
3098101 cgttgatgat gcccaacgac atgagcgcca cgccgaggcg ttcgacggcg aaattggcgc
3098161 gggcgctgtc gcggccgtcc ccctcggcgc aaagcaggcg atccggggtc agccgcacgt
3098221 tgtcgaagaa caactcgccg gtcggcgaag acatcatgcc catcttcttg aacggcttgc
3098281 cctgcgtcag gcccggcatg ccggcatcga gcacaaagac cagcaccggg cggttacgcc
3098341 aatctgaggc gggctcaccg tcggcgagct tggcgtagac caccaggaca tcagcgtacg
3098401 gcccgttggt gatgaaggtc ttgtgcccgt tgaggatgta gtcttcaccg tcgcgggtca
3098461 cgtgagtctt catgccgccg aacgcatccg agccggagtc tggctcggta atggcccagg
3098521 ccgcgatctt ttccagcgtc accagcgtgg gcacccagcg ctcctgttgg gccagggtgc
3098581 cgcggctcat gatcgtcgcc gcgcccaacc cgaggctgac ggccaccgtg ctcagcaatc
3098641 cgatgctgac cccggccagt tcggacacca gcaccgcgac catcgaagcc tggtcagcca
3098701 gcccgaaact gcctgagctg tcccgctttt cccgcttagc ccgctcccca tccagcatct
3098761 ggttgaccga ctcggcaagc agcacgtcca gaccgaactg gctgaacagc ttgcgcgcga
3098821 tcggatacgg cgacagttca ccggtttcca atgcgtcttg gtgcgggcgg atctccttgt
3098881 cgatgaactg gcgaacggcg tcgcgcacca ttagatcggt gtcggaccac tcgaacatgg
3098941 cgtgctccct ccgatcgcgt ggctcaacgt tcggcccgtt ggtatgcggt gaccacggcg
3099001 gcgccgccca gcccgatgtt gtgttgcagc gcggcggtca cgttgtcgac ctggcgcgcc
3099061 tcggcggtgc cgcgcagctg ccaggtcagc tccgcgcact gcgccaaccc cgtcgcaccc
3099121 agcggatggc ccttggagat cagcccaccg gatgggttga cgacccagcg tccgccgtag
3099181 gtggtctggt tgtcgtcgat cagctcgggc gcctcgcccg gcccgcacag gccgagcgcc
3099241 tcgtagagca gtagctcgtt ggctgagaag cagtcgtgca gctcgatcac tccgaagtcc
3099301 ttcgggccga gtccggattg ctggtaaacc cgttgtgccg cttgcacagt catgtcgtag
3099361 ccgatgatat tgcgggcact gccatcaaag gtggaagcga agtcggtggt catcgcctgc
3099421 ccgacgattt ccacagcccg cccggcaagg ttgtggttgg ccaggtaatc ctcactggcc
3099481 agcaccaccg ccgccgaccc gtcggaggtg ggagagcact gcaatttggt cagcgggtcg
3099541 gaaatcatct ttgaggccaa gatgtcgtcc agggtgtatt cgtcctgaaa ctgtgcatac
3099601 gggttgttga ccgagtgctt gtggttcttg tagccgatct tcgcgaaatg ctccgcggtg
3099661 gtgccgtatt tcttcatgtg ttcgcggccg gccgccccga acatccacgg cgccaccgga
3099721 aagccgaact cgtcgatctc ggctaacgcc ttgacgtgcc tgcccagcgg cgactcccgg
3099781 tcgtcggcgc caccgcccag cgctccgggc tgcatcttct cgaagcccag cgccaacacg
3099841 caatcggcca gtccgccgcg gatggcctgc gcgccgaggt agagcgccgt ggatccggtc
3099901 gagcagttgt tgttgacgtt gacgatgggg atacccgtca tgccgagttc gtagagcgcc
3099961 cgctgacccg acgtcgattc tccgtagacg tagccgacgt agccctgttc aacttcgcgg
3100021 tagtcgatgc cggcgtcgcg cagcgctttg gtgcccgact ccctggccat gtccgggtag
3100081 tcccagcctt cgcgtcgccc gggcttttcg aacttcgtca tgcccacgcc aatgacgtaa
3100141 accttgttcg acgacccttg gttaggcatc gttgccgttg caagtgagtg atctttagtg
3100201 gtcacgcgac ttgcaccccg tctcggggtt gttcggcagc cttgcggctg cttcccttcc
3100261 gcgcttcacg gccaccagcc cggccaggcc gggtcttacg gtcggctcca cgcttgacgg
3100321 cggccccaac tgggccgacg acgctactgg tgtcctcgta gcgtgcgagg ttgatcgctg
3100381 cgcagtcatc acgctgatgc gatgccgagc acgaatcgca ttgccagtgc tcggcccatc
3100441 cgatctcttg gacatgcccg cagacgtggc aggttttcga cgatgggaac cagcggtcag
3100501 cgaccactag ttgtgacccg taccagcctg tcttgtagga caggtggcgg cgcggggtgc
3100561 ccagggccgc gtcggagagt ccgcgccggc gagcgcgggc acccgagagg ccctgttgcc
3100621 gcagcatccc tgccgcgtcc aggccttcga caacgatgcg gccgtgggtc ttagccaaat
3100681 gcgttgtcag acagtgcagg tggtgggtgc gaacatcgtt gacccggcgg tgcagccggg
3100741 atatttcggt ggtgcgctca cggtagcgac gtgagccttt cgtgcagcgc gaccgtgccc
3100801 ggcagacatg ccgtagctcg ttgagtgccg cgtcgagtgg ccgtggattc ggcactcgtt
3100861 cgagcaccgc gccgtcggcg gtggcgaccg tggccaggcg gcgcaccccg acatcaacgc
3100921 cgacccgtga accggggtcg gtcaccttcg gttgctgcgg gcgctgcacg aggacccgca
3100981 cactcgcatc gatccgggtc ccgttacggc gcaccgtgat cgcgagcacc cgcgaccggc
3101041 ctttggcgat gagccgctca acccggcgcg tgttctcgtg ggtgcggacg gtcccgatga
3101101 ccggcagcgt gaggtggcgc cggtcgggct cgacgcgcat cgctccggtc gtgaacgtca
3101161 cccggtctgg gtcgcgtccc ttcttcttaa accggggaaa gcccatcctt ttgccatcac
3101221 gtttgcctga tcgcgagttc tgccagttcc agtacgcgtc gaccgcgccg tcaataccgt
3101281 cggcgtaggc ctccttcgag cactccggcc accacacaac accggtctcg atgttgacgc
3101341 acacgtcgtt cttgacggtg ttccagcgct tccgcaacac ccgcagcgac ggctttgccg
3101401 tctggatccc ggtcgcctgc caggcgtcga tatcggcttt cagggtggcg acggtccagt
3101461 tgtaggcctt gcggcgggca ccgaaatgcc gtgccaacgc gcgggcctgc tcggcggtcg
3101521 gatcgagcgt gaaccggaaa gcctgaacca tccagccctc aggaatctcg aatttcgcca
3101581 tcaggcagcc tccgactctt cggcggcggc cgccaatgcg cgcttggccc ggttctgcgc
3101641 agcgcgcttg ccgtacagcc gggcgcacat cgaggtcaag atctcggtca tgtcccgtac
3101701 caggtcgtca tcaacctcgg ccgagtcgac cacgaccagc tcgcggcctt gggcggccag
3101761 cgccgcttcg acgtactcag agccgaaccg gcagaaccgg tctcggtgtt ccaccacgat
3101821 ccgcttcacc gatgggtcac gcagcagcgc aagaaacttt cggcggtgcc cgttcagcgc
3101881 cgaaccgacc tcggtcacga ccttgtcgac cgcgatctgc tcggtcgtgg cccaggcggt
3101941 cacccgcgcc acctgccgat ccaggtccgg cttctgatcc gctgacgaca ctcgcgcata
3102001 cacggccgtc cgcgcccggc gggatctatc ggccggctgg tcgtccacga gaatcagccg
3102061 cccggccttc cgcgccggca ccggcaacaa ccccgcatga aaccagcgat acgcagtcac
3102121 ccgcgcaaca ccgttgcgct cagcccacac cgccagattc atactgttgt tcctacagca
3102181 cgccactgac aactaccgac cactcagacc gcaacagctg acagcccctt ccgaattgaa
3102241 cagcggccca tcgccgtgcg acgtaggccg tgtagcccag tgtgccaccg ttgccgtccc
3102301 ggaccgcatc cccctacatt gaggccaggc tccaaccgaa tcgcccggct cctcctcacc
3102361 ccgctacccg gggtgcatcg tcgccgggcg gagcaccgcc accgacctgg tccgcgaacc
3102421 ctcgtcacgc agcagcgcga taacccggcc gtcggcgtca caggccgcgt acacgccgtc
3102481 gataccgacc gccggcaggg accggccgtt ggcggccgcg ctggcctccg cggcggtcag
3102541 gtcgcggcgc gcaaacatca gcaggcaggc ctcatcgagg ctcaggctca gcgcggggcg
3102601 ctccgcgaga tcgtcgagcg atctcgcctg gtccagctcg aagcggccga cgcgggtgcg
3102661 ccgcaacgcc gtcacatggc ctcccacccc aagcgcgtcg ccgaggtcgc gtgccaacgc
3102721 gcggatgtag gttcccgagg agcagtcgat ctccacatcg atatcgatga gctggtcgcg
3102781 ccggcgtgcg gccagcagct cgaaccggtc gatgcggatc ggccgggctt ccaattgcac
3102841 ggagcgcccc tggcgggcca accgataggc gcgtcggcca ccgaccttga tcgcgctgac
3102901 cgacgacggc acctgccgga tctcaccgcg cagccgctcc atcgcggcgt cgatcgcctc
3102961 gatggtcagg tgcttagccg gaaccgactg cagcacttga ccttcggcgt cctcggtgga
3103021 agtggtctga cccaagcgga tggtggcggc atacgacttg ggggccgccg tcagcagacc
3103081 gaggatcttg gtggcgcgtt cgatgccgat caccaacacc ccggtggcca tcgggtccag
3103141 ggtgcccgcg tggccgaccc gccgggtggc gaagatgcgg cggcaccgcc ccaccacgtc
3103201 atggctggtc attcccgcgg gcttgtcgat aaccacgatt ccggggccgg ttgcgctcat
3103261 agcacgatcg cggtcagcac cagtccgcgc tcaaccgacc agcgtccccg cagcgttgtc
3103321 agcggcggac ccgacagggt ggacccgtcg atgaggatac gggagacgaa gcgacccgtc
3103381 cagccggtgc tatcggtttc gaacgtgatg tgcgcgtcct cgaaacccag ccacctcttg
3103441 gtcagcggaa accacgcctt gtacgttgct tccttggcgc agaacaggat tcgatcccaa
3103501 tgcaacgccg ctggcatggt gcggggcatg tcggcgcgct cggccggcag gctgatcgca
3103561 tccagcacac cattgggcaa cacgtcgtgc ggttcggcgt cgatgcccac ggaacgcacc
3103621 gcatccctgc gtccgacaac cgcgccgcgg taaccggcgc agtgggtgag gctaccgacc
3103681 atgccgtcgg gccagcacgg ttcgcccttg tcgcccttga ggatcggcgc cggcggcaca
3103741 ccgagctggt ccagcgcgat gcgggcgcag tgacgcacgg tgatgaattc gttgcgccgc
3103801 ttggcaaccg atcgtgcgat caacggcgcc tcctcgggca gcggggtgag accgggtggg
3103861 tcggagtaca actcggcata cgccaaatcc tcgaacacgg tcgccggcaa caccgacgcc
3103921 accagcgtgc ctaccgtcat cgagactgcc gttgccgcaa tcgttcccgg aactgggcgg
3103981 cctgggttcg catctcgggc gtgatcacga agtgaccgcc gaagtcgttg aggtagccgg
3104041 gcgcgtattg gggatccggc agcacctgcc gcagccagga gtagggcttg cgccggcgcc
3104101 actcccgcgg gtaacccacc gacacctcct cgaaccgcac accgtcatac caggtggtgc
3104161 ggggaatgtg taagtgtccg tagaccgaac acacggcgtt gtagcgggtg tgccagtcgg
3104221 cggtcttggt ggttccgcac cacagcgaga attccgggta gaacagcgcg tcgcagggct
3104281 gtcgcagcag cggaaagtgg ttgaccagca cggtcggttg catccagtcg agctgttcga
3104341 gacgggcccg ggtggccgcg acccgctcgt ggcaccaggc gtcgcgggtg gggtacggct
3104401 cgggtgagag caggaactcg tcggtggcca cgacgttgcg ttccttcgcg atggccacac
3104461 cttcggcctt gctgtttgcc ccctccggca aaaagctgta gtcgtagagc agaaacatcg
3104521 gcacgatggt ggccgggccg cctcgttcgg tccataccgg gaacggatgc tcgggtgtga
3104581 cgacgcccat ctcgtcgcac atgttgacca gatagtcata gcgtgcgcgg ccgaagatct
3104641 gcatcgggtc gcggttggtg gtccacagct cgtggttgcc cggcacccag atcaccttcg
3104701 cgaaccgccg ccgcagcagg tccagcgacc agcggatctc gtcggtgcgt tcggcgacgt
3104761 cgccggcgac gatcagccag tcgtccggcg aggacgggta cagcgattcg gcgacgggtt
3104821 tgttgccgag gtgaccggtg tgcaggtcgg agatcgccca cagcgtcggc tcggcgccga
3104881 cggtctcctg ccccgatcct ttccaggtca cgacttacca ccctaacgac ccggcgaagt
3104941 gggaacgaaa tccagccagt tcgaccaacc gctacggcgt gagcagacgc aaaagccccc
3105001 atttcgggcc cgaaatgggg gcttttgcgt ctgctcggcc aacctagccc aactgctacg
3105061 gggtcggcga gggttttggg gtgtcggtcc ggctgatccg gcagtccgac tgtgcggtga
3105121 ggaccgccgc cttctgggtc gagcatttga actcgacgcc gccatgaccg gcgaagtaca
3105181 cgtcgtggtc ggccggcttg ttcttcatca ccccaaagcc ggtggcaccg aactgttcga
3105241 caccgtcctt gacgatctgc acggcctgca gccacttgtc gtcggggatc ggtccactga
3105301 aaacgatcat gaaatacgcc gctttggccc tggtccattc atactcacca ccgcagccgg
3105361 tccaggtgtc catatccgtt cgccacgtca ggccgggcac cagggccgtg atggcgttgg
3105421 ccagctgggt caccgccgcc cggtactggt ccttggcgtc ctccagcggg ggcttggcgc
3105481 gcaacgggtt ctccagctcg gcgaccttct ccgggctcaa cggcccctcc tcgccggccc
3105541 gcgtcccgtg gccactgggt ccgcacccag tcgccatcac acacaccaga gccagcagcc
3105601 acgccgtcgg ccaccgcatc aacgtccccc tctcagtgct gggccgggcg ctgccggcat
3105661 gccgccaccc agaattggcg gaagcagcgg cgggcccacc gtgttgtcgg gcagcccggc
3105721 ggcgatcgcc gccaggttat agccggacat ccgcagctgc ggctggccgg cggcatcgag
3105781 gaaggaccgc gggtagtccc cgtgggcata cactccgtca cgccagatcc cgcccggatc
3105841 aaaacccgcc tgtgacgaca gctccgtgaa cccgggggtc agataggggt ccaggcccca
3105901 tccgtgcagc ggcgccaacg gcgccaccag attggtgatg aggtcgtggg gggcctgcat
3105961 gacataagcg tgcccgtgat cgagcccgag ctgcgccggg ctgtacagct ccaagccggg
3106021 tgagccgtaa aacacgacgt cgttgaccgg atgggcgctc tgggcatcga ggtcctgcaa
3106081 cgccagcgac gccgtcagcg acccatacga gtgccccaac acggtcaggt ggccactggg
3106141 gttattggcg cgcacctgct gcaaataccg cgacagatcg gccgcgcccg cgtgtgcctg
3106201 cccatcggtc atggtctgcc acagatcgcc cgcactgccg gtgtcgagtg ggttcggggg
3106261 cgggtggtag cccatccagg cgatggtggc aaccgatgcg ggcttgccgg cagcattgag
3106321 ttgccggatt acctccgacc gcaggtcgcg ggcttcggtc accatgccgg gcagggcgcc
3106381 ccgggtggtg gacccgacgc cgggaaccgt caccgacaca ttggcggcgg tgtcgggatt
3106441 accgacggcc acggccgcca gcacctgctg atttgggtcc tcgggaatct gcagctgggt
3106501 caggtaggtc tcgggtgctc ggctcaacgc ctcgtcgacg gcatcgagct cacccagccg
3106561 gcccctggcg gcgctcagct cgtcggtaag cgctgccagt cggcccaccg cgtcaccgtc
3106621 gaggatgccg ttgtggtagt cacgggcggc ccgcacactc agttggtcat actccgcctg
3106681 taaccgctcg aggtgggcct gcaggcgggc gcgctcctcg cgcagccgct cctcgttggc
3106741 atcgctggcg agctgggtcg gggtcagccc ctcgggaccg accggcgggc cggaatcggc
3106801 cgggatgggc gcgtcaccgt cggccatatt gaccgctgag gccagctcct cgtcgacggc
3106861 attggcctcg gccataatcg catccagctc cgcctgcagc tccgtttgct tggccagcgt
3106921 ccgcgcccac tgcgcctcgg tggatcgcag cccggggatc ggcaccaccc ggttgatcag
3106981 cgcatcgatc gtcagctcgg cggccgcggc ggcatggcgt agtgcggcca gctcggactg
3107041 aaccttcaca atcccgtcgg cggccctgtc ggccgcccgg gcaaccgcca acgcctcgtt
3107101 gccgtgggcg tcgaggtctc ggcgaatgcc cgcgttgtgg tgtgccgccg cctcagcggt
3107161 cttgccaccc gagttcgcaa aaatcgacag cgcggccaac tgacgcgacg cctcgaacgt
3107221 cacctccgct cgggcactgg ccgcgtgaaa cacctcccgg accgcttgcg cgttccaccg
3107281 atcgatatcg gccacggtca gtggcacgaa tcacacccca cgcggaccag ctacgacgtc
3107341 ggcggaaaca cccacctggg cgagcgcctg cgcccgctcc gcctccgccg ccgcatgctg
3107401 gatagcggcc tcctgcagcc cgaatgcgtg atcaccgatc ctggtcagca gcgccctcga
3107461 cgcgtccaac cagtcgtcca tcttggcgtt gagcgccatc gccgaggcgc cctgccagcc
3107521 gaactgggcg gcctgcatcc gatagtccga cgacaaatgt ccgacggcca gaccctcacc
3107581 ctgcgtggtc acctgcgccg ccgagtgcat ccactgctcc ggactgatct gaaacacccg
3107641 ttgcttcctt gcgtccatcg aagtgcatca cattatgcgt cagcgggaac taccgcagaa
3107701 ttcaccgcat caaaggtggc ccgggttaga acaagttctc gtttgactgt gacgacgcgg
3107761 agccgacttg tacactcccg gcaagggacc gccgagggca gggggtgtcg tgttcaccag
3107821 ggtgcggctg atcggagggc tcggtgcgct gacggcagcg gtggtggtgg tgggcacggt
3107881 gggctggcag ggcatccccc cagcgccgac cggcggcgac gcggtccagc tgcgatcgac
3107941 cgcggcgccc atgtccacca cgatgaagag cccgatcgtg gcgaccaccg accccagccc
3108001 gtttgacccg tgccgagaca tcccgttcga cgtcatccag cggctcggat tggcctacac
3108061 gccaccggaa gccgaggagg ggctgcgctg ccacttcgac gcgggtaact atcagatggc
3108121 cgtcgagccg atcatctggc gcacctacgc ccagaccctg ccccccgacg cgatcgagac
3108181 cacgatcgcc ggccaccgcg ccgcgcagta ctgggtgcgg aagccgacgt atcacaacag
3108241 cttctggtac tcctcttgca tggtgacctt caagaccagc tacggggtga tccagcagtc
3108301 gctgttctac tcgaccgtct actccgagcc cgacgtggac tgcccgtcga ccaacctgca
3108361 gcgggcaaac gacctcgtcc cctactacag gttttaggtc cctaccctgg gcgtcgtgag
3108421 taccacctcc gctcggcccg agcggcccaa gctgcgcgcc ctgaccggac gagtcggtgg
3108481 gcaggccctg ggcggactgt tgggtctgcc ccgcgcaacc acccgctaca ccgtcggtca
3108541 cgtccgagtc ccgatgcgcg acggcgtcca gctggtggcc gaccactacg cacccgccac
3108601 gtcgcagccc gtcggcaccc tgctggtgcg tgggccatac gggcgccggt ttccgttttc
3108661 gctggtgttt gccaggattt acgccgcccg cggttatcac gtcgtgctgc agagcgtgcg
3108721 cgggacgttc gggtccggtg gcgtgttcga gcccatggtc aacgaggccg ccgacggcgc
3108781 cgatacggtg gcgtggctgc gtgaacagcc ctggttcacc ggccggttcg gcaccatcgg
3108841 cctgccctat ctgggtttca cccagtgggc gttgctgcac gatccgcccc cggagctggc
3108901 cgcggccgtg atcacggtgg ggccgcacga cttccgggcc tcggtgtggg gcaccggatc
3108961 gtttacggtc aacgacttcc tgggctggag cgatctggtt tcccaccagg aagaccccgg
3109021 tcgcatccgg gccggaatcc gccagctcac cgcgccgcga cgggtggcgc ggacggccgc
3109081 cacgttgccg ctgggtgagt cggcccggac gctgctcggc acgggtgcgc cgtggttcga
3109141 atcctgggtg gaacacaccg accgcgacga tccgttctgg gaccgactgc ggtttcccgc
3109201 cgcgttggac cgcgtccagg tcccggtgct gctcgtcggc ggctggcagg acatcttcct
3109261 gcggcagacg ctgcagcagt accggcacct gcgcgaccgg ggtgtgcacg tcgcgctgac
3109321 ggtcggtccc tggacacaca cccagatgct caccaagggg ctggccaccg gcgctcggga
3109381 atcgttggac tggttggacg cccacctcgg ccgggcgccg gcgctgcgcc ccagcccggt
3109441 gcgggtcttc gtcaccggcc agggctggcg gcacctgccg gactggcctc cggcgaccac
3109501 cgagcgggcg tggtacctgc agcccggtgg ccgcctgggt gagagcgctc cggcttccgg
3109561 cacgccaccg gcgacgtttc gctaccaccc cgccgacccg acaccgacca ccggtggtcc
3109621 gctactgtca tccaacggcg gttaccgcga cgacagccgg ctggccacgc gcgccgatgt
3109681 gctgtgcttc accggggcgc ccctcaccca cgacctctgc gtgcacggaa accccgtcgt
3109741 cgagctggtg cacagctcgg acaaccccta cgtcgacgtg ttcgttcggg tcagcgaggt
3109801 ggacgcgaag ggccggtccc gcaatgtcag cgacggctac cggcgccttg gtgacgcgcc
3109861 ggagctggtc cgcgtcgagc tggacgccat cgcccaccga ttccgcgccg actcccgcat
3109921 ccgggtgctg atcgccggta gttggtttcc ccgctatgcg cgaaacctcg gcaccccgga
3109981 accgatactc accggacggc agctcaagcc ggctacccac gcggtgcatt tcgggcgctc
3110041 ccggctgctg ctgcccgtcg gctaacggct ggtggtgcgg cggacccggg cggcgacccg
3110101 gccgataacc cgagcccgtc cagcggcgcg tgcccagtgg tctccccgac gcggaacctg
3110161 cgagagctac gaccataagt cgagatgcag tttcaaagcc tcatcgagct gggcaagttc
3110221 ggcggctgaa actcggccga ttggccggag caaccgctcg gtagcaatcg atctgatttg
3110281 ctcggcctgc gccttgcagt cgacctggag accagtagtg gtggccgaca acaacacctg
3110341 aaacggatag accttggcga tgttgctcgt caccggcacg acggtgatga cgccgcgccc
3110401 aagacgcgtg gcggtcgcgt tggcccggtc gttgctgacg acgacggcgg ggcgctggtt
3110461 gttcgcttcg ctacctcgag cggggtcgag atcgacctgc caaatctcac cgcggcgcat
3110521 caccgactcc gtcgccgacg gtctgctccc acgcgtccgt gtcgccggct gccgaccatt
3110581 cttgccatgc gttggcatag tcatcttcga gcgtggggta gcgaagcacg cggatcgcat
3110641 gctgcaggcc ggcggagcgg gatggtaatc ccgctcgttt cacatatgcg tccaggatcg
3110701 cgacgtcgtc atcggacagg ctcacgctca acttcacaac ctaagatgct accagggtcg
3110761 tacctaggta gtaataggtt cagcggctgg tcgcgcgcca gtcgcgcagc acttcctcga
3110821 cgtgctcacc cacccggtgc cgcgccgttt cccggtcgac acccgacatc agcagttcgt
3110881 cgaacgaagt gtcgatatgc cgcaccgacg ccgcgacggc cagcctcacc gcttcgggat
3110941 cgagcgcccg tccggccgcg ctacgtccga tcctgccgct gccgcgggtg gccgcgtggc
3111001 gggcgatcgc ctcggcccgg ccggccgggc agttcgggaa cagcgtgcga atcgcggcgc
3111061 cgaattcggc ttgcagacgc aggtcctcgt tggcccgtcg cgcctcgtcg cgctcccggc
3111121 ggcgggcgcg cacctccgca tcggcgaggc actcgttttc ggcgcgctcc agcgcctccg
3111181 cctcgaccag gatgccctga cgctcgtatc gcttacgcgc ccggctccac cgcaccacca
3111241 ccgccgaaag ccggctcgcc cgcttggccc ggcgggtaag cgcggcgtcc ccggacggca
3111301 agaagaccag atggccaagg tccgcgcagt ccaggcacaa cggccccgcg tcctcaagga
3111361 acatcaggtc accgctgccg ccacacgacg cgcatgacca gtcgttgacc ggcatgatca
3111421 cgaccaaatc ggggcgccgg ctctgccgcg cgaccgcacg ctccgagagc tccggcgaca
3111481 cccaatgcgt gcgatacgcg cgctcgatgg cgtcctcgcc ggtgacgctg aaccgcagcc
3111541 gacggcggtc ccgagtgcga gcgacgtaat cggtctccga cgggttgagc ccccggtcgc
3111601 gggcccagcg ccgcaacgcg gccatcacgg cggtgatctt gctgaggttg gcctgtacga
3111661 cttgctccag cgagtcgacg cggccctgcc gccactggtc gacatgcgag ggcgccagcc
3111721 agcccaggcc gagcagcaca tcgatcgcgc tgacgaaccg ctgtcgggcc agcgccgcct
3111781 gcgccgcccg ggccacccgc tgctccagag gttgacgtgc catgacctgc ccgagcctag
3111841 tcggactgcg caccgaggcc gcggaactga gttactccga ccagccggac gcgctcggag
3111901 tggcgatgcg cgaacgtcgg gaacaacaga acctcgttcg gccgccacgg agaaacgctt
3111961 ctcgccgcat caacaccgat cagacgtcga cgaagtacgt ctacattacg tacatgcccg
3112021 agactctgac tggtcgcctc aacttccgcc tgtctcctga acaggagcag gcccttcgcc
3112081 acgccgccgc gctcaccggc cagagcctgt cggggttcgt attgtccgcc gcggtcgacc
3112141 acgcccacga tctcttggcc cgggccaacc ggatcgagct gtccgaggcc gctttccgcc
3112201 gcttcgtcgc cgcgctcgac gagcccgacg aggcggctcc cgaattggtg cgcctcgcca
3112261 gacggaagag ccgcattccc ccccattgag cacccccgcg ctcggccccg tcgagctgtt
3112321 ggacccggac cggcacgaca cggcgcgctt ctccagcgat gttgaggttc tcgaccactg
3112381 gctgcgccga gtcgcgcccg tcgcggctgc cgccggcacg gccgctacgt gggtgctctg
3112441 tcgaggccgg cgggtagttg ggttctacgc gctcgccatg gggagcatcg agcggatccg
3112501 ggtgccatcg cggccgggcc ggggccaacc cgacccgacc cgatcccagt gctcgtcctc
3112561 gctcgcctgg cgctcgaccg gcaggagcaa ggcaccggtc tcggtggcga tcttctcctc
3112621 gatgccctca tccgatccgt ggccggtgcc cggcactacg gcgcccgcgc cctggtcgtc
3112681 gacgccatcg acgaccgcgc cgccgagttc tacggtcacc acggcttctt gcccctcgag
3112741 ggtcgacgcc tctaccggcg gatcagcgac atcgcgcggg cgctgggagt atgaagcgct
3112801 atcgtcgctt ggcgacgtgc tgccgatcga tcgcctcgaa tggcctcgtt gttgttgtcg
3112861 tcggtgatgg ggaggggcaa cggcaagatt ttggatccgg tggtggccac cacggggatg
3112921 ggccgctcga cggcgcggca gatgttgacc ggcccgaggt tgccgggccc ggccgagcag
3112981 gtcgacgggc gtagccttcg gcctcggggc ttcagcgacg aagccagggc gctgctggag
3113041 cacgtgtggg ccttgatggg catgccgtgc ggcaagtacc tggtggtcat gcatgacctg
3113101 tggttgccgc tgttgaccgc tgccggtgat cttgacaagc cgctcgtcac cgaggcgtcg
3113161 gtggccgagt tgaaggcgac agccctacca ggggcgaatc gcatgccgca ctgggccgca
3113221 gggacactcc ctgatggctt tccagcccgg gcggtgagga cgcgcacgtg aaaaccaacc
3113281 cccggtacgg cccggcgttc tactcagtga tgacggtgtt gttcctggcg ctgttcgtgc
3113341 taaatgtgtg cacccacggc tcgacgctgg gcctgatcag taccggaggc ctcgccgtgt
3113401 tgatgggcta catcggctac cggggctggt ccggcaagcg ccatatcaac cggcaatagc
3113461 gatcatcgac cggttccggc acacctgacc agcgccgtcg tcggccgcca accccacggc
3113521 tcgtgtgcca gccgacggtc accgtgtcgc ggcggcggga cacgaggaaa ctgcccacca
3113581 gccacaccta cttcgcgctc acttttaagt gaggcacttc ggcatcgaag gcggataaga
3113641 ccaagatcct ggatcgggtg gtgtccacca ccgggatggg tcgttcgacg gcccggcgga
3113701 tgctgaccgg cccggggctg ccggagccgg ccgagcaggt cgacgggcgc aggctgcggg
3113761 cgcggggctt cagtgacgac gccagggcgc ttttagagca cgtgtgggcc ttgatgggca
3113821 tgccgtgcgg caagtacctg gtggtgatgc tcgagctgtg gctgccgctt gaggccgccg
3113881 ccggtgatct tgacaagccg ttcgccaccg aagcggcggt ggcggagttg aaggcgatga
3113941 gcgcggccac cgtggaccgc tacctcaaac ccgcccgcga gcggatgcgc atcaaaggca
3114001 tctcgacaac caaaccctca ccattgctgc gtaattcgat caccatccac acctgttcgg
3114061 atgaggcgcc caaggtcccg ggggtgatcg aggccgacac tgtggcgcac tgcggcccga
3114121 gtctaatcgg cgagttcgcc cgcaccctga cgatgactga tctggtgacc ggctggaccg
3114181 agaacgcctc gatccgcaac aacgcggcca agtggatcct cgagggcatc aaggagtgcc
3114241 agcagcggtt cccattcccg atgacggttt tcgattcgga ctgcgggggc gagttcatca
3114301 atcacgacgt cgccggctgg ctgcaggccc gcgacatcgc ccagactcgc tcgcggccgt
3114361 accagaagaa cgaccaggcc catgtcgagt ccaagaacaa tcatgtggtg cgcaaacacg
3114421 cgttctactg gcgctatgac accggcgaag agctggagct gctcaaccgg ctatggccgt
3114481 tggtgtcgct gcggtgcaac ttcttcaccc cgaccaaaaa gcccgtcggc tacaccagca
3114541 ccgtcaacgg tcgccgcaag cgcatctatg acaagccggc caccccatgg cagcgcctgc
3114601 aggcatcggg cgtccttgat gcacagcaac tctcgaccgt ggccgcccga atcgaaggct
3114661 tcaacccggc cgatctgacc cgccagatca acgcgatcca aatgcagctg ctcgacctgg
3114721 ccaagaccaa gaccgaggcc ctggccaccg cccgccacat cgacctgcaa tcattgcaac
3114781 cgtcaatcaa ccgattggcc aaggcgaagt aatgcaagcc ccccacgcgc tcactatgcg
3114841 tgaggcacca gccacgcttc gcgctcactt ctacgtgagg cacctcggat gctgttgcga
3114901 atcctgttgg gccgccccag tttaaagtgg atgagcttgg tagaggcgct tacgtgtacg
3114961 ttgggaaaga cgcaacagtg gtcctaaaca aagatggcca agtggtaacc gcctgggcga
3115021 acagccgggc tggatggaga aatccgtgag caacgttctc gatgctattt caacggagca
3115081 ccgtcccgtg atcgagcaag aattagagaa tcgtaatccc gctctcttcg acgagcttcg
3115141 gcgcacagag aagccaacca acgaacagag cgacgctgtt atcgacgtgc tttccgacgc
3115201 cttgatgaag acctttggac ctgattgggt tccgaatgat tatgggttga aaatcgaacg
3115261 agcaattgac gcatacttag agacgtggcc gatataccga taatcgcttg acaccaacta
3115321 ttgccagcac caggcgccta ccgtgcatcg ggagcgcggc cgggctggta ttcgcgtggg
3115381 actgaaggag cttaggcagg aacgcacatg acgtacgcag ccagggacga tacgacgctc
3115441 cccaaactgc tcgcacagat gcggtgggtg gtgctggtgg acaagcgtca gctcgcggtg
3115501 ctgctgctag agaacgaggg accggtcgct tccgcgacgg acacgttgga tacgcgcggt
3115561 gatagcgact atgaaaacca gccggtcgac gcagtggagc ggctatgtcg gcgtttggct
3115621 gaccaggcgg tgcgtcagtg gggttttatg cagggcctca agcagaagct cggaccaggt
3115681 gtcgacgtgc ggatgaagct ggtggagtgg aaccgatgag ctttaatggc tcttccggaa
3115741 tcagagtgca tggatcagct gagccaggtt gccgcagtgc agtagtgaac ggattcggta
3115801 gtgggtgagg tttctgaatc cgagggcgtt acggcatagg gcttccagtc gtccgttgat
3115861 ggcttcggtg ggcccgttgg acgcgtggtg gtcgaagtag gccagcacat cgtggcggca
3115921 gcgccacagg gtgcggccta gtttggccag ttcctctagt acgacaggga caccggttcc
3115981 ggcgctgacg gtgagcagcg cgggggcttg ccgtacccgg gtttgttgtt tgtagtgccg
3116041 gggcggctcg gtgatcaggt cattggtagg cgacggccct cccgtcgtct cttgccggag
3116101 tgctacggga gggccgcctg tgtgcgcttg gaggcgcagt ggtcaccgta gaagcagatg
3116161 tcgatcaagt cgagcgtcgg ctggcggccg gtgagctgag ctgcccgtct tgcgggggtg
3116221 tgctggcggg ctggggccgg gctcggtcgc ggcagttacg cggcccggct ggtccggtgg
3116281 agttgtgccc gcgtcggtcg cggtgcaccg ggtgcggggt gacgcatgtg ttgttgccgg
3116341 tgagcgcgtt gctgcgccgc gccgacacgg cggcggtgat cgtgtcggcg ctggcggcga
3116401 aggccaccag ccgggtcggg ttccgccgga tcgccacgga tgtggctcgc ccggcggaga
3116461 cggtgcgggg ctggctgcgc cggtttgccg agcgtgtcga ggcggtgcgg tcggtgttca
3116521 cggtgtggct gtgcgcggtc gatgccgatc cggtgatgcc ggatgcaggt ggcggcgggt
3116581 tcgtcgatgc ggtggtggcg atcggcgcgc tcgcagctgc catcgggcgc cggttttcgc
3116641 tgcccacggt gtcgctggct gagaccgcgg tagcggtgtc aggtgggcgg ttgttggcgc
3116701 cgggctggcc cggcgagtgg gtgcaacacg agtcgaccct gccgtagccg tcgatcgggc
3116761 cgtaaacctg tgcgctgtcg tgtgttttga cagacagcaa atggaaagga gcggccggtg
3116821 gcggtcggcg atgacgagga gaaggtgcgc gcggagcgcg cgagggcgat cgggttgttt
3116881 cgctaccagt tgatttggga ggccgccgat gcggcgcatt ccaccaagca gcggggaaag
3116941 atggtgcgcg agttggcctc acgcgagcac accgatccgt tcgggcggcg ggtgcgcatc
3117001 agccgccaaa ccatcgaccg ctggatccgg ggctggcggg ccggcgggtt cgacgcgctg
3117061 gtgcccaacc cacgccagtg cacaccgcgt accccggccg aggtgctgga gctggcggtg
3117121 gcgctgcggc gggaaaaccc gcagcgcacg gcggcggcaa tccggcggat cctgcgtacc
3117181 cagttgggct gggcgcccga tgaacgcacc ctgcaacgca acttccaccg gctcgggctc
3117241 accggcgcca ccaccgggtc ggcgccggcg gtgttcggcc ggttcgaagc cgagcacccg
3117301 aacgccctgt ggaccgggga tgtgttgcac ggcatacgga ttgatctccg caagacctat
3117361 ctgttcgcgt tcttagacga ccattcccgg ttggtgcccg gctaccggtg gggccatgcc
3117421 gaggacacgg tgcggctggc cgccgcactg cgcccggcgc tggcctcccg cggcgtgccc
3117481 aacgcggtgt atgtcgataa cggctcgccc tatgtggatg cgtggttgtt gcgggcatgc
3117541 gcgaaactcg gtgtgcgcct tgttcattcc acgccaggtc ggccgcaagg caggggcaag
3117601 atagagaggt tcttccgcac cgtgcgcgag cagttcctgg tcgagatcac cggcgaaccc
3117661 gacgtcgtcg gccgacatta cgtcgctgat ctggccgagt tgaatcggct gtttacggcc
3117721 tgggtcgaaa cggtttatca ccgcagcgtg cattccgaaa ccgggcagac cccgctggcc
3117781 cgctggtcag ccggcggccc catcccgctg cccgcccccg agacgctcac cgaggccttc
3117841 ctgtgggagg agcaccgccg cgtgaccaag accgccaccg tctcgctgca cggcaaccgc
3117901 tacgagatcg acccggcgct ggtcggccgg aaagtggagt tggtgttcga cccgttcgat
3117961 ttgacccgca tcgaggtgcg gctggccggc gcgccgatga ggcgggccat tccgtatcac
3118021 atcgggcgcc attcacaccc gaaagccaaa cccgaaaccc ccaccgcacc gcccaaaccc
3118081 agcggcatcg actacgcgca gttaatcgag accgcgcacg cagccgaact cgcccgcggc
3118141 gtcaactaca ccgccctcac cggggctgcc gatcagatcc ccggccagct cgacctgctc
3118201 accggccagg aggcccaacc gaaatgatgc acaaactgat ctcgtattac ggtttttcgc
3118261 gcatgccatt cggccgcgat ctggcaccgg gcatgctgca tcgccacagc gcgcacaacg
3118321 aagcggtcgc ccgcatcggc tggtgcatcg ccgaccgccg catcggcgtc atcaccggcg
3118381 aagtcggcgc cggcaagacc gtcgccgtgc gcgccgcact agcgagcctg gatcgcagcc
3118441 gccacaccat catctacctg cccgacccca ccgtcggcgt ccagggcatc caccaccgca
3118501 tcgtcgcctc gctcggcgga caacccctca cccaccacgc caccctggcc ccacaggccg
3118561 ccgacgcgct agccgccgaa caagccgagc gcggacgcac ccccgtcgtg gtcgtcgagg
3118621 aagcgcacct gctcggctat gaccaactgg aggcgttgcg gctcttgaca aatcacgacc
3118681 tcgactcgtc aagcccgttc gcctgcctgc tcatcggcca acccaccctg cggcggcgga
3118741 tgaaactcgg cgtgctcgcc gcgcttgacc agcgcatcgg actccgatat gccatgccgc
3118801 ccatgaccga caccaacacc ggcagctacc tacgccacca cctcaagcta gccggacgcg
3118861 acgatgccct gttctccgac gacgccatcg ggttgatcca ccagaccagc cggggctacc
3118921 cccgcgcggt caacaacctc gccctgcaag ccctcgtcgc cgccttcgcc gccgacaagg
3118981 ccatcgtcga cgaatccacc acccgcaccg ccatcgccga agtcacggca gactgaacac
3119041 cacaccgaca ccccgaacac caccgacccc gccggacatc tcccggcggg gtcatttcat
3119101 gaccaaacgt cctcaccgtc aacgccgcca tcatgctcat cctgaatgcc ggtcaacaga
3119161 cgcggtggcg acccagtcgt cgtagtttcc gtcccctctc ggggttttgg gtctgacgac
3119221 tcgggcacgg ccgaaacacc gcgcgaaggg cggttcaagt ttccgtcccc tctcgtggtt
3119281 ttgggtctga cgactgggag gatgtcactc ggacatagct gtcatcggcg gtgtgtttcc
3119341 gtcccctctc ggggttttgg gtctgaggac atggagcagt agcgtggctg tggtgtggcg
3119401 ggcgatatgc gtttccgtcc cctctcgggg ttttgggtct gacgactgct gcacctcccg
3119461 cacccggtgc gattctgcgt ccagtttccg tcccctctcg gggttttggg tccgacgacc
3119521 ccgatagtcg cgctcgtcca tgtcccacca tgagggtttc cgtcccctct cggggttttg
3119581 ggtctgacga ctacctgata gaagccggaa agctccgtgc cgtcaggttt ccgtcccctc
3119641 tcggggtttt gggtctgacg acagggcact ggacctgtat gaggcacaga tggcgtacta
3119701 gtttccgtcc cctctcgggg ttttgggtct gacgacccgg atcggttacc cacgccgatt
3119761 tactggccat cgtcgggttt ccgtcccctc tcggggtttt gggtctgacg acacttgcgc
3119821 gcacaacgca tccgccatcc acggggcgtt tccgtcccct ctcggggttt tgggtctgac
3119881 gacctgaaag ggggactgtg gacgagttcg cgctcaaaat gtttccgtcc cctctcgggg
3119941 ttttgggtct gacgacttga acacgccgat acctatttgg tcgggagtga taaagtttcc
3120001 gtcccctctc ggggttttgg gtctgacgac cggacttgat cgacgcgaac ctgtctgacg
3120061 cgaacctgtt tccgtcccct ctcggggttt tgggtctgac gacggctgga aaagggcgcg
3120121 gggcaaccgc atcgtcaaga gtttccgtcc cctctcgggg ttttgggtct gacgacgcgt
3120181 tgtggtcgtg tcgtggagcc tgtatttcgc tggtttccgt cccctctcgg ggttttgggt
3120241 ctgacgacca ttagttggtg ttgtgatcgc taaacgccgg ggcagtttcc gtcccctctc
3120301 ggggttttgg gtctgacgac ctatccgcgg gaagagatca cgaatccggc gtcgaagggt
3120361 ttccgtcccc tctcggggtt ttgggtctga cgacatgctg agctgaggcg ccggatgatg
3120421 gtggtgctga aggtttccgt cccctctcgg ggttttgggt ctgacgactg acagggtgcg
3120481 gtggtcgctg atcggctccc cgagtttccg tcccctctcg gggtgaaccg ccccggtgag
3120541 tccggagact ctctgatctg agacctcagc cggcggctgg tctctggcgt tgagcgtagt
3120601 aggcagcctc gagttcgacc ggcgggacgt cgccgcagta ctggtagagg cggcgatggt
3120661 tgaaccagtc gacccagcgc gcggtggcca actcgacatc ctcgatggac cgccagggct
3120721 tgccgggttt gatcagctcg gtcttgtata ggccgttgat cgtctcggct agtgcattgt
3120781 cataggagct tccgaccgct ccgaccgacg gttggatgcc tgcctcggcg agccgctcgc
3120841 tgaaccggat cgatgtgtac tgagatcccc tatccgtatg gtggataacg tctttcaggt
3120901 cgagtacgcc ttcttgttgg cgggtccaga tggcttgctc gatcgcgtcg aggaccatgg
3120961 aggtggccat cgtggaagcg acccgccagc ccaggatcct gcgagcgtag gcgtcggtga
3121021 caaaggccac gtaggcgaac cctgcccagg tcgacacata ggtgaggtct gctacccaca
3121081 gccggttagg tgctggtggt ccgaagcggc gctggacgag atcggcggga cgggctgtgg
3121141 ccggatcagc gatcgtggtc ctgcgggctt tgccgcgggt ggtcccggac aggccgagtt
3121201 tggtcatcag ccgttcgacg gtgcatctgg ccacctcgat gccctcacgg ttcagggtta
3121261 gccacacttt gcgggcaccg taaacaccgt agttggcggc gtggacgcgg ctgatgtgct
3121321 ccttgagttc gccatcgcgc agctcgcggc ggctgggctc ccggttgatg tggtcgtagt
3121381 aggtcgatgg ggcgatcggc acacccagct cggtcagctg tgtgcagatc gactcgacac
3121441 cccaccgcaa accatcgggg ccctcgcggt ggccctgatg atcggcgatg aaccgggtaa
3121501 ttagcgtgct ggccggtcga gctcggccgc gaagaaagcc gacgcggtct ttaaaatcgc
3121561 gttcgccctt cgcaattcgg cgttgtcccg ccgcaagcgc ttcagctcag cggattcttc
3121621 ggtcgtggtc ccgggccgtg cgccggcatc gacctgcgcc tggcgcaccc acttacgcac
3121681 cgtctccgcg cagccaacac caagtagacg ggcgacctca ctgatcgctg cccactccga
3121741 atcgtgctga ccgcggatct ctgcgaccat ccgcaccgcc cgctcacgca gctccggcgg
3121801 gtacctcctc gatgaaccac ctgacatgac cccatccttt ccaagaactg gagtctccgg
3121861 acatgccggg gcggttcagg gttttgggtc tgacgactcg cggcgagcac gtctcaccca
3121921 gcaggcggtg aggttgggtt tccgtcccct ctcggggttt tgggtctgac gacacggacg
3121981 agctggaccg catcagcgat gctgagctga gggtttccgt cccctctcgg ggttttgggt
3122041 ctgacgactt gtctcaatcg tgccgtctgc ggtgacacgc tccaagtttc cgtcccctct
3122101 cggggttttg ggtctgacga ccaccaggat cagcgccaag ccagttagcg caatccagtt
3122161 tccgtcccct ctcggggttt tgggtctgac gacctcccgg accatctgca gctcgcccgg
3122221 gtccatgcgg tttccgtccc ctctcggggt tttgggtctg acgaccggag tcatccgcgc
3122281 gggccggcgc gattgttgcc gggtttccgt cccctctcgg ggttttgggt ctgacgactg
3122341 gcgatttacg acgctgacgg gaactcgtgc gaatgtttcc gtcccctctc ggggttttgg
3122401 gtctgatccg cgaaattcac tgcgcgttat tcaaggtttc cgtcccctct cggggttttg
3122461 ggtctgacga cccgagccga ccatccgcat cacaccgaaa gggttggcgc aagtttccgt
3122521 cccctctcgg ggttttgggt ctgacgacac gtggggagag ggaatggcaa tgatggtcga
3122581 cgaagtttcc gtcccctctc ggggttttgg gtctgacgac ctcggacagc atctccccgg
3122641 gcgggcagca gatatcccat gtttccgtcc cctctcgggg ttttgggtct gacgaccgac
3122701 ccgtggccgc caggttgccg ccgccgttgc tcacctggtt tccgtcccct ctcggggttt
3122761 tgggtctgac gacccggaag tcaactagag cgggtgtcga acgctgcccg gtttccgtcc
3122821 cctctcgggg ttttgggtct gacgacatgc gaatccgctg tcagcacatg ggattccgag
3122881 tgtttccgtc ccctctcggg gttttgggtc tgacgaccta ggcggccccg gcgaggctgg
3122941 gggcggtttc acgcgtttcc gtcccctctc ggggttttgg gtctgacgac cagcgcagac
3123001 ggcagccccg agtactcgct ctcctcaggt ttccgtcccc tctcggggtt ttgggtctga
3123061 cgacaggctg aaattgaagc cggaaatgac gacgcattgg tgtttccgtc ccctctcggg
3123121 gttttgggtc tgacgaccta agcccgctaa tcccgcacaa gtggtcagaa aagtttccgt
3123181 cccctctcgg ggttttgggt ctgacgacct gatgattggt cggcgtatga cgtgctactg
3123241 aggtgttgtt tccgtcccct ctcggggttt tgggtctgac gactagaagg cgatcactgg
3123301 aagcacggcg cttgcgagtt tccgtcccct ctcggggttt tgggtctgac gacttggtca
3123361 aaagctgtcg cccaagcatg aggcaaaaag tttccgtccc ctctcggggt tttgggtctg
3123421 acgacacgac taggggagcg tgatccagag ccggcgaccc tctatggttt ccgtcccctc
3123481 tcggggtttt gggtctgacg acgtgcaaga attccgggtt gcagtgcaac acggttttaa
3123541 gtttccgtcc cctctcgggg ttttgggtct gacgactcta tggacaattc gtccagcgtg
3123601 tggtaacaat gcctgctgat gatgtcaaaa gaacacaaac tcctctgcgc tgacaagccg
3123661 tccccttccg tagaacgtaa ctgccgcaac acctcttatc ttatagatcc ggatgttgtc
3123721 gcagtcgatg gcgaagcggt cgatacgtgc aactagtttc gcgagctggc ccttcgtcag
3123781 catcgcttcg aatgcggact cttggacgcg atagccaaac ccggccagga tcttcgcaag
3123841 tgaagcccgc cgccggttgt cgctgatgtc gtatattacg aggacgaaca tcttgcctat
3123901 agtgccgctg gactcgtcca ctttgagcgg gagattgaag tactcctcac ggctgcgagt
3123961 gggcatttag gctccggatg gctcggaggt gatatcgata tcgacgagcc gcgacgggtg
3124021 cccggcttcg ataacacgca cgaggctttg cagttgcaag tcgagggcgt actgaaaggt
3124081 gtatcggtga ggatcgcctt tgatgtaggt ggcggttcgt gcgattcgat taccaaaggc
3124141 gcgcgcgatg gatcgtgtgg cttcccgtgt cgcgaagacg gcccccgtgt cggagttctt
3124201 gctgaaagcc cgggtgtcga ccacaccgtc cgcgatcaat cgaagtacgg tgtcatcgat
3124261 gatcggcgcc cgccatacct ccatgaggtc gctcgccaac gttgcgtgcc ctcgtgaatc
3124321 ctggtgtagg aaaccgatat acgcgttcag gctgtgacgc tcgatcgccc ctatgatgtt
3124381 cttgtacagc agcgaatagc cgaggctgac catcgagttg aaggcgtcca acggcggccg
3124441 agtcgagcgg ccctggaatg cgaactcctg cgggacgaga tgccccagcg cggtgaagta
3124501 tgcctttgcg gcatttccct cgaacccgtt caactccgcc agggagcccg atcgatcgac
3124561 ccaggccagc gagtgcttca tcgtgcggat gctctcagca acgtcttgcc ccgacgtgtg
3124621 tgcccgaatc aaggcctgct gattcaggat cttcctcgac acgatccgct tgcttaacga
3124681 caggcagaac gcaggatcgt cggtgcggtg aacttgctga cggagccgcg gcgcgtatga
3124741 cacgtcgggt gttgagatcc ggccctggta gtggccgtcg gtcgtgaaga gctggatgtc
3124801 gcgctcacgc ttgagcatct caacgatgaa gggcgttgtc atcgtcggcc gcccaaacag
3124861 cgtgatgccg tccagcgtct cgatcggata ctggctctcg ccgagctcct cgctccacac
3124921 gatcacccgg ccgtcggcaa agctgatccg cgacacggag tccgagacat acagctgcac
3124981 catcttgcgc acctgttagc ccagcggtgc catatcaatc tgccggatga tctcgtcgtt
3125041 caaccggtca tagagcgtca aatcagcgcc tgtttcgcgg gcgaggatct tcagcagttg
3125101 ttctgggaga aggccgccat ccttcgtgat gcgatcctca ctgattgaga cgatctcgtg
3125161 tgctgcggtg ttgcggaccc ggctctcgaa ccttccgagt acttcaagag caccaactcg
3125221 atcgggtgcg aattggcgga gcagtgcgag ccagtccttg gtgtagaggt accactccgc
3125281 gtttggcgat ttcggagggt gcttgagcgc gcaccgtatc tccggctctc tttccagctt
3125341 tcggcggtcg acgcggccca tgtcgtcgag atagcggtcc tccggaaggt gttttgccac
3125401 agccgccctg agcacgatag tgattgccgg ggtagctgat cgtgcgaatt cagcccattg
3125461 ctcgcgcttt gccagcagcg caagagcact tatgtactca gcgaccttgt tcgcggggtc
3125521 atacgtgaac gcggtgtcct taaagaactt tggcgctacg aggtgttcca gcctcgagcg
3125581 gtgcatcgcg ccgcggatca gattgctcac ttgatcgggc aggcgcgagt ctgccgcgat
3125641 cgtcactgct gccgagtagt cgtacgacac gatcagctgc ttcaggttgg cccgctcaag
3125701 cagcgcgccg agcgcagcgg aagtcgcctc aaagcaacgg ttgggggctc caggctgatt
3125761 gtcgtcgttt gcgtcccaca ttagttcgag gtcgtaagcg tctggggatt cacgatcgcc
3125821 aggcttgctc aatgcccggg caggcgtgct tacttgcaca gcggtggtcc tgggaatgcc
3125881 aaacacattt atggccacca gcgccgcctg catcgcaggg gtgccggaac tggtattcag
3125941 cagaatggtt cgatcaggga actcagccga cagttcaacc aggtggttgc ggaaaaccgg
3126001 cacgaaaagg tcgaacctgt gcaccgacgg gttggtatag gtgactatgc gaacgtcggt
3126061 ctcaggcgcg agccgcgtga ttgccgcgga gtaccgccgg tccgcgttct caaaggcagc
3126121 tatctcggcg ctgaggaata gcacgacaac tattggtcga tagtggcgga cgatgtgtag
3126181 catcgggccg tcgccgagcg cggtgatcgg gtccgcagtt ccgataggcg agaacaggat
3126241 cattcggctc tcctgatcga cagctcgcac tgacccatct cgtagcatat gttgtcgatc
3126301 ttggttcgct tcaagacaag tggtgagacg cgtagttcgc gcgtcttgtc gacgtgcttg
3126361 actaccttcc cgaactgggc gtcgagcacc ttcgccatgt cgtcttggtc ggtgacaaag
3126421 gtcttgctcc gatagccggc tccgccgccc agatagacaa ttgggccaac tatcgcgttc
3126481 acgccagggt acatggctct gtactccgcg taacgcgcct gattcacgga cgcggctgtc
3126541 tcggccagcg tttcaaggaa ccgctcgccc tcacgccagc cgccgcgagc ggtgggactg
3126601 gtgtcgacca ccacgcggtg cgagattgag gttcccggcg ccaaacattc ccggaagagc
3126661 ggcaggccat caggcttgcc gtggacattc atgtccatct tctggcagat cagcagatcg
3126721 cttgttctca gtgcaggtga gtcggtgacc ctgatcgcct gaaacaggtc gttgaccgcg
3126781 tcttgcggac gggtgttggg gcgccccgat ttgcgcaact ccttccgctc aaacctttcg
3126841 ccgtactgcc ggtgctcccg cgtctggtgt cccggaacac gaacaggttg ggccgtccgc
3126901 ttatgcacaa gcgactgcag gtagatgctg cgaagcattc ccttgacagt cgaacccggc
3126961 acgtagggcc ttccaagagg gtctttgatg aaagcgtgaa tctcgttgag cgtaagcttc
3127021 tttcgagtca tgcgcccgcc tcgaccacga gatgcacgtc gcggttcgat cgacccgatc
3127081 ttcacctcgt aacctcgatg cttagcagga tccagcttga ccgcgtttgg ctctacccac
3127141 tctttgagtg gcgccgtcgc ctgtgcccca tcggtgttca tgacgaacgc ttcgaaagac
3127201 ttcctcttgt gagccggaat gtctgcgtaa agaagttcca tgtccgggaa gtagacccgg
3127261 tcgccctcca cgtggtactc cttcgaggtc cgcttctcgc cggatccgat aaacaccggc
3127321 cccaggcacc gcagcgtgag ttcgaacggc ttcaggtagg tgttcatgcg gcggactccg
3127381 ggagtgcgag aaatagcggt cgcgcgtagc tgtagaccgg atggtttccg cccaggctga
3127441 cgtcgaggat gcctccttgg aagggtcgcg agaagaccga gccggcggcg aatttgtaga
3127501 tgtcgcgttt gcgcaggggc atgtcagcgt atgtgctcga cgcgacgaat ccactgcgct
3127561 tgacgaggcg gtacgtcgcg ccggcgagtg cggcttcgag ctcgtcgtcc gtgggtaggg
3127621 atgtcgtgag cgtcatcaga ctggccgcgt cgactgtcgg cgtgagtgcg gcgggtgctt
3127681 ctgactcggt aaggttaaac gctccgaacc cgcttgtccg ttcgccgccc agcgcggaga
3127741 tccctttcaa cagcctggtg agtaggccga gctcggactc ggatccggtc gccagcaacc
3127801 acagacccgc gtccagctcg aaccggaagt agccgacacg gtacgggtcg gcgtctttct
3127861 ttccgttgtg gatcgctgcc ttcgctgaca cggcgtggac accgatcttg gtctgccgcg
3127921 ccgcgagttc tttcaggtcg gccgtgccat cgaggaagct gccaagctgg gcagcgggaa
3127981 gaaagccgat cttcttcgcc agcttcttct gcatacttga gccgtcggac cgaacgctgt
3128041 gcaggggctt gggaaccagg taatcgggcc ccacataggg cagcagatcg gtcaaccgca
3128101 gcgtcgagca cgcaacgagt tcgccaagca gctgctggcc acccatccgt agcgcttcaa
3128161 cgcaaagcgc agagtagagg gtgtccgcgg ggcagctaat cgtggacgac tcgaggccgt
3128221 ggtcgccgaa gtgtgtgcgg tcgaagtcga acctaaacag ccgcgagttc atggtttagc
3128281 ttctccagca gagaaccgtc gagggcgccg actgcggcgc gggctttcag gttgctgaac
3128341 ttgacctgcc cgtagccacg ggttccgctg ccgccgaggt agtcgagttc gagcaacttc
3128401 aggccgcgcg cgatggcgtt gaagtcctcg atgatctcat cggaggaagg cagagacgcc
3128461 ttctgttcct cgccgggggt gccgaaggag acctcgtaga caagtgagaa cgcgaactcg
3128521 ctgccgggga tcacgcgttc catctggcga aggtttgcct ttgcggtcac ccggttgatg
3128581 gcgttctcga atttcacctc ggtgagagtc ttagcgccgc gggcttcgag gtcgtctttg
3128641 ttggtgagct tcgtgtcgcg gaagacgagt cggcccgtca tgtactcctc ggtgtcgccg
3128701 aaaagccgac ggatatgggc gtggtcctca ttcggcttcc tgtaaaacgt ttctgtgtcg
3128761 gcgccgtatt ggcgggacag caaggtgcgg accttgccct tcaggctggt acccggaatc
3128821 atcggcagcc tgctcagcgg atcacgaacg acaggcttgt cgaccgcgcc gatggcggag
3128881 aagccatcgc cggccccgat ctgcaggccc gtcaggacgg tcagtgtccc ggttatctcg
3128941 atcttggcgt agctcgtagt cattgggttg tctcacttgt ccttcggatc gaggtacttc
3129001 ttgtatgcgg ctagggcttc catgtaccgg cagaatcgca gcagcccgtc gcggctatcg
3129061 cctatccctt ccagcgcttc taggagtttc gcgtttcgga cgaatgtctt aaccgcgtct
3129121 tcacgcccgg actggtagac gaaccggacc cgcaggtact ggaccttctc cttcagctga
3129181 cgcgggagcg tggggttggc gctctgctgc gcctcgtcga agagctgtgc ggtcaggctg
3129241 agtagcaccc gcagctgggt tgtggtcagc tcgaagccgt tctttttctt tggcaggccg
3129301 cgaattactt cggcctgttt cacatagtcg tcttggatga cgctcattcg gactcctcct
3129361 tgcgagtgcg atagatgtag aggtgcagcg cggtcttgag ttgcttggcg tctgtcggat
3129421 cttggaacca ttggtgtagc cggttagcaa actgctgaaa aggcgctgtg tcaccggtgg
3129481 ggttacgcat gcgcgtgagg aagtacaccc atctggcctt tgtgattcga tcgtcgcgtt
3129541 cggcgagtag ttcgagcagc ttgtagatga aggccatgcc gcgttcttcg ttgccactga
3129601 aatagtcggc gatgtgccgg tacttctcct cgatcacctt gctgagcagc tcatcccagc
3129661 cgaaggtgaa ctcgcgatcg aagagtgcaa ccccgttctt gccgggcagc gacttcgccg
3129721 cgtcttcgag atctccgact tcgcgggcca tcacggagat ggggtacttg tcggggaaca
3129781 tgccgatgcc agccgacacg gtgagtttgc cctgggtgaa ttcgtggaac cgctcccgaa
3129841 gctcgatccc gaactcgatg acgtcgtccc acgcgcccac gacgaagacg tcatcgccac
3129901 cggagtagat gatcgtggcc tcgcggggcc gcgccgggtc atcgccggtg atcgggcgca
3129961 gtttcgggcg tgccaacacg tagttgatgt gctgccggaa gaacaacgac agcatccggg
3130021 agaacgcggc cgtgcggcta atcgtgttga acttgccgtt gccttgctcc atgaagccgt
3130081 gcgtgaatgc ctggcccagg ttatcgacgt caaggcgcag aaccccgagg cgcgcgattc
3130141 cgctcgcacg cttcacgtag tcaccgaact ccatctgtgc gacgtagtcg cccacccaga
3130201 gcccggtgcc caaacactcg ccggcgaaga acttgttctt cgcgtaccgc cttcgggttt
3130261 ggggttgctg gagtgcctta tcggcgtcgg ctcggctaca gaacgtgagt gtggcgccga
3130321 acggcagggg cagacctttg gtggcgccgt cagagatgag taggaagcgg cgagactcgg
3130381 attgaatctg cgaagacgca gcggtcagcg cttggcacag gctgcacttt ggctcgtcgt
3130441 cggcgctgac cgtgcggttg accgtgtggc acacgctgca ttcccggtca cctttctgac
3130501 cgtcgtgatc gcgcgagttg agttcccgca gttggtcagc gctgtatcgg gcgagcttct
3130561 tcgcggaaag ttgctcgctc aactcacggt agagcccgct gtagcggagg gcgcggttac
3130621 ttgcctggct cgcactctcg ttcggccgac gcatcaggtc gttcgcggca agcggtacgc
3130681 tgcccgtggc gatgaagagc cgggttgcga agttttccag cagccagtcg ttggcctcac
3130741 gctcgaactg ttcgacggat ttccgcgcgg actccgtgtt gggcagcagc aggtacgcgt
3130801 gcccgccgcc ggagtagttg agattcgcgc ggctgagacc cacccgcgca agtagctcgt
3130861 cgatgagatg ctcggtcagc atctccaggt agaagctgcg ggcacgcagc atcttcgcgg
3130921 cacccgagga atggatcgtg tagatgaagt cctggatgcc tgagacgtcg aaagttgtga
3130981 gcaggaaggc tttttcgttg tagaaggtgt cctgcttgtc gaacagcgct gacttgaagt
3131041 cgctttgtcc ggtggcttgt aggtagtgcc agatgcaggc gccgagcgca cccgtcagct
3131101 tcaggtggtc gaagagtgag acgtcgacga cctcggacgc gtcggtcgag gacggcacga
3131161 acgacagcgt cgcctcgagg acgttgagga ggctggcgag gtaggtgtcg gaacgttcga
3131221 ggtcgaccag aatggcttta agtttgttga cgatggcggc gtagcggtcc ttgtcgaatt
3131281 cgatccggcg tggcgacggt atattgatcg gcttgcggtc gtcgagcatc tccggggcaa
3131341 atgccagatt cgctgtgccg gagccgaatc ggttgaacat cgaatacagg ggcgtgtccg
3131401 gatcccaagt gctcgcacca tggccgtcgt cggagtcggc cttgcggcgg tcggttccgg
3131461 ccgcgatatt gtaggcgatg taggccggcg catcggcggc aaggcggcca ttctcggccg
3131521 ccgtacgcag cgcagaactg tggtgatagc tgatcgcgtc gagaatgcgg cggtcggaga
3131581 ccccaatgtc agcctcatcc acctcgtcgg tgaactgcga cggattgcgg ctgtcgcgca
3131641 accacacctt cttcataaaa gcgcggccaa tcgcactgtg cctgcccggg tagccgagcg
3131701 ccgcgcgctg gaccggtttg ccaatgtcgt gcaagaggca gccgattatg gcctcgatga
3131761 gttgcgggtt catggcttcg gtacgcattt ttccctcggt gccagtggct ggacccggat
3131821 cgcgcccatc cccatggatg cctttattcc gcatcccgag aactccccga accacaacag
3131881 cgccgcgata tagctcgcaa aagtatccac accgcggacg gtgaacgtgg ccgagccggt
3131941 gaagccggga acacgcgccg cgcccaccgc gaacggggcc gacgccaccc ggaacgcgga
3132001 gaggcgaacc gactgaccga attcggcgat gaggccagga tcgggctctt cgccgtcgac
3132061 aattgcaccg tacttctgcg cgagactctg aaacacgagc cgcggatccg gccagaacac
3132121 gtactcgccg gattgcttga atgcggtagg cgtcaggaac tcgacccgga acttgcgcgt
3132181 ctcgggccgc gcgtagaaaa tgcgcgcgaa ttgacttagc gggttctgct ccagcgatcg
3132241 cgacgtgacc tgtgtcgcta tcccgctcgc acggagccga aaacccgcaa acgccgcgtc
3132301 gttgataggt ccgacgatct gctgccgcgc ctcgttcgtc agcgtgctga tcttccactc
3132361 caaagatgtg gtcgagcggg ccagcgcgta ctgactgtac gggttcaccg gcacggtgtg
3132421 gagggtctgc acataatcgg ccgggatcga ctccatgagg acgccatgaa gatgcggccc
3132481 cagggtcgcc accctcgcgc gttcgagcgg ggcatcaacc tctagagtca gcgtcaatcg
3132541 cgacaagtgt tccgtcatcc ggcgatctcc tcggtgagaa aagcccacca gaataagcgt
3132601 tggtgaaatc caggtcaagc ctgattccgc cgcactcgcg cgatgtcggc ctcggggctg
3132661 gccactccga cgtagcagat ccgtccttct gatgccgcct cggcgagcag ccaagggatg
3132721 gcttcctaac gagccggggt tgtagcggtg ggcgccggcc gcgcggagga tggcgccgcc
3132781 aatgctgctg ttgcccgcgc cgtcaattga cgccagcagg gaccgaaccg acagcagatc
3132841 actcgcagcg ccgactgggc gtacagctca gacccaagcg atgccgccca gtcaacccac
3132901 ggcctcgcgg acccgggcgg cgacctcggc cagcgcggcc tcgtcgtgca ccggcgccgc
3132961 caacgtcggc gtcaccggca gctgcaccca gctggtgcaa ccgccgtact cgggcctacg
3133021 cgccagccgg accggctcgg ccagcgggat cgccgagacc accaagacgg ccagtttgtg
3133081 cttgggccga aagtcgagcc ggtcggcgcg caccgactcg gcggtccaga tgtgcagatc
3133141 ctcgatggcg tccagaccct ctggccggtt aaccggcagt gcggcaacaa ctttcgctgc
3133201 ggcccgcagt agcacacact cgtcggtgct gtcggcggcc gccgggccca gcaggtcgcg
3133261 gtgctcgggg cgaacccgct cggcgtggct gtgcgcgacc gtcgggaaca acaagaactc
3133321 gtgggccgcc acctcgaagc gcttctcgcc gatcccgccc ttacgcagca gcaccgtctg
3133381 ccggccgtcc agcagcgcgt gcaccgccgc gctccactcc ttcagcgctg gcgtcaccac
3133441 gatcccgcga gccggaccga tgtccgaatg acgccagcac cgcagggttc cgaggggacg
3133501 ccgatcatct ccgagacgtt ttgccccggg cagtttcatt ggtcctgctg aatcaggccg
3133561 gtcatccagt gcatccaata gtgatgacag tactcgtgtc ttgctcacca ccacagccgg
3133621 attcgtgccc aactgctctc atctagtcga ttcagccgcg tccagccgca accgtgccag
3133681 cggaacggca cgatcgccgg caggttgatc aggaccgcag caccgccagc gcgttctcca
3133741 cttcgcggcg gtgccgttcg tcgcaggcgg cccaccgctg ctcgtcggcg tcgaggtcag
3133801 tgaggaacgc aaatcgcttc cgaacgcgag cttcccaggc agccatagcg acaggacggg
3133861 tcagcacgcc gatcgagtcg ggctggaagt cgtgctcgct gcgggcggcg aggacgtctt
3133921 cgacgcgtag tggccgggtg ccgcgccggt catcgacgac atcaccccac accttgagca
3133981 cccacagccg ccgcacgagc ggttcgtcaa tcgttcgcga ggcgaagtgg ttcaggtcgt
3134041 acaggtcccg tgccagcgca acgcggcggt accgcgcgag tttctctgcg caggcttccg
3134101 cttctgccac gaccggcagt gtcggcagcc caaaaccgta agccttatgg atcggcaact
3134161 ggatgaatgc gagcagctca gacggcaaag ccaacggccg ccgtgcgaac tcgacgctgg
3134221 cgacgatccg gggctcgccc aattccgtgt gccgcacccg caactgccaa tgccggccgt
3134281 cgcctcgtgt gctctgcacg ccgaattcga agccgccgac acgggcgccg tcgatcagct
3134341 cgcacacctc cagcacgacc tcatcgtcgg gcgcgctgaa gtccagatca gtggagaacc
3134401 gcccgacgtt gcccagccgg cacttccgta agctggtacc gcctttgaac accaggcggt
3134461 tatcgccgaa ctggacggtc tgcgacagca ggtacagcag gtggtcctgg gcgacgtcga
3134521 gcagagcggc gtcgtatgcc tcggcccgac caagagcgtg acgcgcaacg agcgcacggg
3134581 tcagaccggc cacagtcacg ccttgccgat cacgcgcagc agcggtacga cgagctcgtc
3134641 gacaagctga tactcgggag cccagacact ctcgccacgg tcgcggctgt gcgcggtggt
3134701 gaatcgagtc accggcatca cttcggtgtg ccgcttggcc agcagcgcct ggcctcgtgc
3134761 cggttcaccg cccgagtcca gcaggtagct tgcacgctgc caggccgatg tcggccggcc
3134821 cgacagtaga cgctccaggc gctcgtcact gcagtcggcg acgaggtcgt caaggtgggg
3134881 gacaaggtcg gcccacggcc cgaacgaggc cgggcgcgtg gcgatttgca caagtaatgc
3134941 ttctggtcct agcgccggta acccggtcgc ccacgcgacg aggtcgagcc gccgccggac
3135001 cagcaacgcg ggacgcggag ccagcagtgc ggtgtccgcc gcgttccagg ggatgcgcac
3135061 gacggacaca tacgatgcta ggccgtcggg cagccttttg gccggcggca gccagatcgg
3135121 gatgcggccg tcgggttggc ggtccaggta tccgaggtgc cacgctgcgg atgcaccggc
3135181 cagcatgaag cccgcgttct ggtcacgggc cagccacgag cgcagcggta gatacgggtc
3135241 cgagatggcg gcctcgccgg ggggaatgaa tgcccaggtg cctttcaccg gcagttggac
3135301 cagccaccca atgcggcgca gttcgcggat ggcggagtcg gggtcgcgtc cacacccagc
3135361 ctctgtaagc cgttgcgtca gatcctcttt cgtgacgact acgggccgat cgcgagcgag
3135421 gccggacacc acccgtgacg cccacgtggg gatgcgccga tcggcgccgg ctgggctcac
3135481 caccgaactt gaattcacac cggaaactat actatatctg tacgcaacaa tgttcaaact
3135541 caagaaatca cttgatttag gaacgggctt cggtcagtga cagtacgaaa cccgttccaa
3135601 actcaagtgc cctgtacggg ctggcggcga tgcggtgcaa cggcgagaga caaaacgcgc
3135661 ttcgcggacg accggccgac gcgccggaga gtcgccaaga acgtcacccc tgaaatcaag
3135721 tgggaccagg atgcactgac gcgttgctcg gaccagtcac ccaggcgatg cgcctcggct
3135781 caaaaactca acccacggcc tcgcggaccc gggcggcgac ctcggccagc gcggcctcgt
3135841 cgtgcaccgg cgccgccaac gtcggcgtca ccggcagctg cacccagctg gtgcaaccgc
3135901 cgtactcggg cgtacgcgcc agccggaccg gctcggccag cgggatcgcc gagaccacca
3135961 gcacggccag ccgatgcttg ggccgaaagt cgagccggtc ggcgcgcacc gactcggcgg
3136021 tccagatgtg cagatcctcg atggcgtcca gaccctctgg ccggttaacc ggcagtgcgg
3136081 caacaacttt cgctgcggcc cgcagtagca cacactcgtc ggtgctgtcg gcggccgccg
3136141 ggcccagcag gtcgcggtgc tcggggcgaa cccgctcggc gtggctgtgc gcgaccgtcg
3136201 ggaacaacaa gaactcgtgg gccgccacct cgaagcgctt ctcgccgatc ccgcccttac
3136261 gcagcagcac cgtctgccgg ccgtccagca gcgcgtgcac cgccgcgctc cactccttca
3136321 gcgctggcgt caccgcgatc ccgcgagccg ggcagccacg tcgggtcggc gcaacggcgg
3136381 gacggtcttc ggcggctgcc gccggggcgg cagggcgtcc agcaaccgcg tcgtcgtcgc
3136441 ggtcacctcg gcgacggcgg cctcaaacgc ctcggcggtg gccgccgacg ggtgcgtgat
3136501 gccactgacc ttgcgcacat actggcgcgc cgccgccgcg atctcgacgg gcgtggccgg
3136561 gggttgcagc ccgcgcagtt cggtgatgtt gcggcacatg ccctcaacga taggcgcggc
3136621 taccagacgg tgaccggtcg tgggtgccga tgactgcgta gccgccggtc cttggtcacc
3136681 agccgccagc cgtgttcgat cgcggtggcg tagatcaacc ggtcggccgg atcgccgggg
3136741 aacgacgagg gcagcgccac cgccgtggcg gcgaccgagg gcgtgatacc gacggtgcga
3136801 acgtgctcgg ccagctgctg aagccaggac agcaccggaa tcgccagttg gatgcgttcc
3136861 tgttcggcaa gccaagccag ctcgaaccac gaaatcgcgg cgacggcgag ctcgtcggcg
3136921 tgttcgatgg cctggctcgc cgccatgctg agacgctgcg gctcggccga ccaccagtag
3136981 gccacatgcg agtcgagcag caccgtcgtc atgaaacgtt ccacgaaacc ccggtggtga
3137041 agagttcgtc gtcatccgcg gccgccatcg ccacacccga gaatcgaccc ttcagcgcgt
3137101 gcggccccgt cgctgccacc agccgggcca cggtgcggcc gtgtttggtg atctcgatct
3137161 cctcgccctg ggccacttca tcaagcaagg agaggatctt cgccttcacc tccgtagcgg
3137221 tcatttttct ggtcattagg acagtctaac ggtcctgtta cggtgatcga atgaccgacg
3137281 acatcctgct gatcgacacc gacgaacggg tgcgaaccct caccctcaac cggccgcagt
3137341 cccgcaacgc gctctcggcg gcgctacggg atcggttttt cgcggcgttg gccgacgccg
3137401 aggccgacga cgacatcgac gtcgtcatcc tcaccggcgc cgatccggtg ttctgcgccg
3137461 gactggacct caaggagctg gccgggcaga ccgcgctgcc ggacatctca ccgcggtggc
3137521 cggccatgac caagccggtg atcggcgcga tcaacggcgc cgcggtcacc ggcgggctcg
3137581 aactggcgct gtactgcgac atcctgatcg cctccgagca cgcccgcttc gccgacaccc
3137641 acgcccgggt gggcctgctg cccacctggg gactcagcgt gcgcttgccg caaaaggtcg
3137701 gcatcggcct ggcccggcgg atgagcctga ccggcgacta cctgtccgcg accgacgcgt
3137761 tgcgggccgg cctggtcacc gaggtggtgg cccacgacca gctgctgccc accgcccgcc
3137821 gggtggcggc gtcgatcgtc ggcaacaacc agaacgcggt gcgggcattg ctggcgtcct
3137881 accaccgcat cgacgagtct cagaccgccg ccgggctgtg gctggaagcc tgcgcggcca
3137941 agcaatttcg cactagcggc gataccatcg ccgccaaccg cgaagccgtg ctgcagcgcg
3138001 gccgcgcgca ggtgcgttag cggcgatcgc aagcgcggcg aagccgggtg ctgggggtac
3138061 ctcccgcgtg cgggggacgg gtcgccgcca tcagcccttc agcgaagccg ggtctcggtg
3138121 cggctgttga agaggcgcac ctcctgcgag tgcggcacga tcgccaacga ctcacccacc
3138181 cgcaccgcgg tacgccggtc ggtgcggaac acgatgcgcg gtgcgcgtga cgaccagccc
3138241 cgctggtcga ccggcgttgc gtagacgaag gattcgaagc cgagctcctc caccaactcg
3138301 acgtgcacgg tcaacgatcc cggggtgccg atcgatgcca cgtcccagga ctccggccgc
3138361 acgccgacca gcacccgctc ggccgccggg tccggaaccg gtatcgccaa atccggtgcc
3138421 cgcaccacac cgtgggcgac ggcggcgtcg atgaggttca tcgccggcgc gccgatgaac
3138481 gtggcgacaa acgtgttgac cgggtcgtca tacagcgccc tcggcgtgtc aacctgttgc
3138541 agcacaccgt ctttgagcac cgccacccgg tcgcccatcg tcatcgcctc cacctgatcg
3138601 tgggtgacgt agacggtggt ggtgcccaac cgacgctgca atccggagat ctgtgagcgg
3138661 gtgctcaccc gcagcttggc gtccagattc gacagcggct cgtccatgca gaacacccgg
3138721 ggccggcgca cgatcgcccg gcccatcgcc acccgctgcc gctgcccgcc ggagagcttg
3138781 gcgggcttgc ggtccagcag atccgtcagc tccagcatgt cggcgacttc cagcacccgc
3138841 cggcgggtgt ccgcgcgcga catcccggcg tttcgcagcg cgaaccccat gttggcggcc
3138901 accgtcatgt tcgggtacag cgcgtagttc tggaacacca tcgccacgtc acgcgcccgc
3138961 ggcggcagat gcgtcacatc cacgtcgccg atgctgatgc gcccgctctc aatgggttcc
3139021 agcccggcca gcacgcgcag cgtggtggac ttgccgcaac cggacggacc gaccagaacc
3139081 agaaactccc cgtcggcgat gtcgaggtcc aagttgtcga cggtcggcgc gtcggcgccg
3139141 ggatagcgct gggtgacagc agagtactga acgttagcca tgccccgcca gcttccgcat
3139201 gatctgccga tccaggatga cctgcaaccg tttttggatg ttcgtgaagg tcttggtcac
3139261 gtcggctccg cgcagcccga tggattccag gccggcggag atgatccggt caccaccggg
3139321 caggaaaacc cgtgcgtagt cttgtgtccg ggtgtgtggc agctggtcga gcgccacccg
3139381 cgcacgggga ttgtccgcca gatagtgccg ttcgctggca tcgtcgacgg cggacttgcg
3139441 caccggcaga tagccggttt gctggctgaa gtaggcggtg ttcgtcgggt tggtgacgaa
3139501 tgcgatgaac ttgagcgcgt tgacttttcg ctcctcggag agcttggccg gtatcgccag
3139561 ccccgcaccg cccgtcggac aggcgggcgc tgcgtccggg cccgtgggca gcggtgcggc
3139621 gccgaagtcg aatcgggcag atgcggtgat gccggccagc gagccggtgg atgccacggc
3139681 cgaggccagg attccggtgg cgaactcgtt ggcaatatcg ttggcgaccg ccgcataacc
3139741 cttgccatgg atggagttcc gatagaagtt gccggccgcg atcgtggcgg gctcggtcaa
3139801 tgtcaatgtc cacttgtcgg agtaggcacc gccgaatgcc cagttcggtc cctgaaacgt
3139861 ccacgagatg aggtcggcgt tagcccagcc gtgcgccgat cgaccggcgc cgaccacgcg
3139921 ctgtaactcc ggaccccact cgtcgaactc tgaccaggat tgcggtccgc ggtcgggtag
3139981 gccggcctgt tgccacgccg ccttgttgta gtagaacagc ggcgtcgagc gagcatacgg
3140041 cacagcgtaa tggcggccgt tgaactcata gtcggccagc agcgaatcga cgtaatccgt
3140101 tgtgtccacc ccaacttggc cgaacaggtc gtcaagggca gtgagaacac cgctgagggc
3140161 gaaatggaac caccatcggt cgtcgagcaa aacgacgtcg ggcacgtcgg ttccgatgag
3140221 cgccgcattg aatttctgtg ccacctcgtc gtagtccttg ccggcgtcga tcagcttgac
3140281 cgacagagtg gggaatcggt cctggaaacg accgatcagc tcccgttccg ccgcgctgga
3140341 ttggccggga tgactggacc agaagtcgat tgggccggaa ccggacttca ccgaaccgcc
3140401 gccgcccatc ccggcgcagc cggcggtcac gccggcggcg gcagcggcca gcgcgaggaa
3140461 ttgtcggcgg ttcagcgggt ccatgcctat cccttgaccg cgcccgaggt gaggcccttt
3140521 atcatctgcc gctgcaaggc gatgaagacc agcaagatcg gcagcatcgc caacagcgtc
3140581 accgccatca ccgggcccca gttcgtcaca ccctcggcct gctgcagaaa cgtcagacct
3140641 atcggcagtg gtgccaccga ttcgtcgtcg gacatcagga acggccacag gtattcgttc
3140701 cattcgttga ccacggtgat gacaccgacg gcgaccatgg tgggccgcga catcggcaac
3140761 accacccgca gcagcagttg ccaccaccgc gcgccgtcca tccgggccgc ctcgatgatc
3140821 tcggcgggca gcgacagaaa gtggttgcgc atcaagaagg ttccaaacgc cacccccgcc
3140881 agaggcagga tgatgccggc aaaggtgttg cgcaggccca ggtgtgagat cagcgcgtag
3140941 ttggaaatca cggtgatctg gttgggcacc atcaacgcgg cgatgatcac caaaaacacc
3141001 gccgtgcggc ccgggaaccg gacaaacacc aagccaaagg cgctgagcac accgagcgtg
3141061 aacttcacca ccgccagcac cgacgtgatg atcagcgagt tgcgcagaaa cgtccagaac
3141121 ggaatctgct cggtggccgt gcggtagttc tgcgggtacc agcgcagcgg ccaccaactg
3141181 gtgggctgcg catagatgtc gggctgatcc ttgaacgagg tgaagaacac gaacagcaac
3141241 ggcccggcaa tcagcgtgac caccagcaac atggccgcgt agccaacgct gctacggagc
3141301 cgatccggcg tcactgccgc tgcccccgat ccatcacccg cacctggtag tacgtcacgg
3141361 ccagcagcac caggaacatg atcgtggcca ccgtggcgcc ataaccggcc cggaaattgc
3141421 ggaacgtctc cacatacacc tggtacacca tggtggtggt gccggtgccc tccggcccgc
3141481 cccgggtcat cacgttgatc acatcgaaca cctgcagcga gttgatcagc acggtgatcg
3141541 acaagaaaaa cgtggtcggc cgcagctgcg gcaacagcac tcgacggaac acggcccacc
3141601 ggctggcgcc gtcgatttcg gccgcctcca acagatctcg gcgtaccccc tgcaacgcgg
3141661 ccagatagat cacgaaggta tagccgaggt tcttccagac gtaggtgatg gtcaccatga
3141721 acaacgccca gcgcgcatcc tggtaaaagt cgggcacccc gaccccgatc cggcgcaaca
3141781 ggtcttgaat cagaccgaaa tgcgggtcga agacgaactg ggcggccagg ccgacagcgg
3141841 caccggagat cacgaacggc gcgaaaacag tggagcgcac caggtttcgt ccacgcaacg
3141901 gtcgatcgag cagcatcgcc agcgccaacc ccagcaccat cgagccgacc accgcggcac
3141961 cggtgaaaac cgccgtgttg aacacgatct ggcgggtgtc cgaccgggtg aaccactcgg
3142021 tgtagttgga taaccccaca aatcgggccg acggatcgga gacgttccag tcgaagaacg
3142081 acagccggat gttgtcggcc aacgggcgat agacgaacag cagcaatagc gccacattgg
3142141 ggccgaccaa cacgacgaac agcgcataat cgcgcacgcg ctctttcgat gaccgaagcc
3142201 gtgctcgttg cggcgccgcc atcggcgcag tgtagctccg tattctgtcg gcgagtttgc
3142261 cgccacggtc gatgaaccaa tcaccgccgt cacggcaatg tcggccagct acgccgcgcc
3142321 cgtcaccgcc caccgaccgc tgtacgcccg ccatccgacg aatatcagcc gcagcacgat
3142381 aaacgtgccc agtcccgacc agatacccgc cagcccccag ccatacgcca gcgacaacca
3142441 gacaagcggc aaaaagccca ccaacgcact cgccaccgtc gccgtccgca tgaacgcggc
3142501 gtcgcccgcg cccagcagca ccccgtcaac tgcgaaaaca attcccgcaa aaggcaattg
3142561 gactaccatg aaccaccacg gcaccccgat cgcggcgagt accgatcgat cgtcggtgaa
3142621 tagcccgggc agcaccgagg agcctagccc taacgccgct gccaaaattc ccgccgccaa
3142681 cagcgaaaac gccgtcaccc gccatgccac cgccttagcg tgcccggcat caccggcacc
3142741 caacgcggca ccgaccagcg actgcgccgc aatcgctagc gaatcaagaa ccagcgcaag
3142801 aagaccccac aactgcaaca cgacctggtg ggccgcgagc gcggcagcgc cgaacctcgc
3142861 ggccaccgcc gcagccgaga cataacaaac ttggaaggcc agggtccgca cgatcaggtc
3142921 ccgcgccatc atcagctggg cgcccagcac ggcgcggtcc ggccgcagcg acacccgctc
3142981 ggccagtaac gcaccggcaa acagcagcgc cgccagccac tgccccacca gattggccac
3143041 cgccgagccg gttaaccccc agcggggcaa ccccagccaa ccgtaaacca gcagcgggca
3143101 cagcagagcc gacgacccga agccggcgac cacataccgc agcggtcgca cggtgtcctg
3143161 cacgccgcgc agccagccgt tgccggcgag cgagaccagg atcgccggcg tgcccaggat
3143221 cgcgatccgc agccacggca aggccgccgc ggtgatgcca tcgccagaag cgatcgccga
3143281 caccagcggc gtcgcggtgg cttccaccac gacgacgacc aacgcgccca gacccaacgc
3143341 caaccaggtc gcctgtacac cttcggtgac cgcggccacc cggttgccgg caccgtaacg
3143401 acgcgccgcg cgcgctgtgg tgccgtagga caaaaacgtc gcctgggaac caaccaggcc
3143461 gagcaccaga ctgccgatag ccagacccgc cagcgatatc gcccccagcc ggcccaccac
3143521 ggcgatgtcg aacagcaggt acagcggctc ggcggccagc acgcccagcg cgggcaacgc
3143581 cagctgcgcg atctgacggc cgcccgcgcg gtgccccacc tggctcaacg gcggctaacc
3143641 aagcgccgcg cgcaacgacg ccacagcgtc gtcgatcgag ccggtggtcg tataccccgc
3143701 ggccagccgg tgaccaccgc caccgaaccc agaggcaacc gcggccaaat tcacggtctt
3143761 agcccgcatc gacaccgacc accgatgcgg ttcgacctcc ttgaacaccg ccgcgacctc
3143821 ggcttgttgc gtggtgcgga cgatgtcgac gatgctttcc acttcctccg agcgcgcagc
3143881 gacccactcc cggttgtcga cgacgacgta aaccagcccg cggccaccga ccgcctcgga
3143941 caccagctgc gccgaaccca acacccgcga tagcaacggc aaccaggtga agggatggct
3144001 gtccatcaag gtcctgctga cggtggcgtt gtccacaccg atctctacca gccgcgccgc
3144061 cagccgatac ccccgcacac tggcccagcg aaacgacccc gtgtcggtcg ccaacccggc
3144121 gtagatgcag tgcgcgacgc gcgggtctat cggtttcccc cacgcgtcga ggatctcggc
3144181 aaccatcgtc gtggtggaat ccgccgacgg gtcaatgaaa ttcgcggtgc cgaacaggtc
3144241 gttggaggcg tgatggtcga ttaccaggag ctcccgcccg gaatcagtta gatcgcccag
3144301 agcaccgagc cgatcaacac tcggaatgtc aacagtcaca accaaatcga catcgcggcg
3144361 catcacctca gggcggacca gcagatggca gcccggcagc gaacgcagcg actcgggcag
3144421 tgtcgccggc gcggcaaagc tgacctctac ccgcttgccg cacccgtcca acaccaatgc
3144481 caatgccaat ccggcgccga tggtgtcggc atcggggtgg acgtggcaga ctaccccgac
3144541 cctggcagcg gccgacaaca gcgcagcggc accgacggcg tccacgcggg cccccgcgcg
3144601 acgccgcccg tcgaccagct cactccttgg gtcgatcgtc gtcaccggtg tctcccccgc
3144661 aagtgagcgg tgcctccaca gcctcgggtc cgtcgctcgt tctgataccc agtcccccgg
3144721 gagccggtga ttgcgccacc gacccgttat cacggtacgg gtcggcctcc cccgccggtt
3144781 tggcgcccac ccggacccgc gccagatcgg catccgcggc gcgagcgcgg gccagcaact
3144841 cgtccatccg gtgcacactg tccgagatcg tgtcgagcgt gaacgtcaag gtgggagtga
3144901 accgaacgcc ggtgcccgcc ccgaccttgg tgcgcagcac ccctttggcc cgttccagcg
3144961 cggcggccgc gccggcgcag ttcggctcgt cgtgtagcgt gcgtcccatc accgtgtagt
3145021 acaccgtggc atcgtgcaag tcggcggtca ccttcgcatc ggtgatggtc accccggcca
3145081 atccaggatc cttgatctcg tactcgatcg ccgaggcgac gatcgcggcg atccgtttgg
3145141 ccagccgccg cgccctagca gcatcagcca tcaggcgcgt tccttctgga ccagctcgta
3145201 ggactcgatg acgtcgccct ccttgatgtc ggcgtaaccc agtgtcaggc cacactcgaa
3145261 gccgtcgcgc acctcggtca cgtcgtcctt ctcccggcgc agcgaagcga tcgaaaggtt
3145321 ctcggcgacc acgatgttgt cccgcaacag ccgcgccttg gcgttgcgcc gcatcacacc
3145381 cgaggtgacc aggcagccgg cgatgaggcc gaccttcgaa gaccggaaca acgcccggat
3145441 ctcagcccga cccagctggt tttcctcgta gatcggcttg agcaggccac gcagcgcctg
3145501 ctcgatctcg tcgatcgcct ggtagatgac cgagtagtag cggatctcca cgccttcgcg
3145561 gctggccagc tcggtcgcct tgccttcggc gcgcacattg aaaccgatga tcaccgcatc
3145621 ggaagccgac gccaggttga cgttggtttc ggtaatgccg ccgacaccgc ggtcgatcac
3145681 ccgcagcacc acctcgtcgt ccacctggat acccatcagg gcctcttcca gcgcctcgac
3145741 ggtaccggcg ttgtcgccct tgaggatcag gttcagctgg ctggtttcct tcagcgccga
3145801 gtccaggtcc tccaggctga tccgcttgcg tgagcgcgcc gccagggcgt tgcgcttgcg
3145861 agcgctacgc cggtcggcga tttggcgggc gatacggtcc tcgtcgacga cgaggaagtt
3145921 gtcgccggcg ccgggcaccg acgtgaagcc aatgacctgc acaggccgcg acggcagcgc
3145981 aacctcgacg tcttcgccgt gttcgtcgac catgcggcga acacggccat aggcgtcgcc
3146041 ggcgaccacc gagtcaccga cccgcagggt gccgcgctgc accagcacgg tagccactgg
3146101 gccgcgacca cggtccaagt gcgcctcgat cgccacaccc tgggcttcca tgtcggggtt
3146161 tgcccgcagg tccagcgcgg cgtcggcggt cagcaacacg gcctcctcca gcgcctcgat
3146221 attggtgccc tgcttggccg agatgtcgac gaacatcgtg tcaccgccga attcctctgg
3146281 cactaaacca tattcggtaa gctgcccgcg aatcttggcc gggtcggcac cctccttgtc
3146341 gatcttgttg accgccacca cgatcggcac gtcggcggcc tgcgcgtggt tgatggcctc
3146401 gaccgtctgc ggcatcactc catcgtcagc ggcgaccacc aaaatggcga tatcggtcgc
3146461 cttggcgcca cgggcacgca tggcggtgaa cgcctcgtgg cccggggtgt cgataaaggt
3146521 gatcagccgc tggctgccgt ccagatcgac ggccacctgg taggcaccga tgtgctgggt
3146581 gatgccgccg gcctcggcct cgcggacgtt ggccttgcgg atggtgtcca acagccgggt
3146641 cttgccgtgg tcgacgtgac ccatcaccgt caccaccggc gggcgaacct gaaggtcctc
3146701 ctcgccgccc tcgtcctcac cgtagctgag gtcgaaggat tccagcagct cgcggtcttc
3146761 gtcctccggg ctgacgacct gaacgttgta gttcatctcg ctgcccagca actccagcgt
3146821 ctcgtcgccg accgactggg tggccgtcac catctcgccg aggttgaaca gcgcctgcac
3146881 cagcgccgcg gggttggcgt cgattttgtc cgcgaagtcg ctgagcgacg cgccgcgtgc
3146941 gagccggatc gtttcgccgt tgccgtgcgg caaccgcacc ccgccgacga ccggagcctg
3147001 catcgagtcg tactcctggc gcttctgccg cttggacttg cggccgcgcc ggggcgcacc
3147061 acccgggcgg ccgaacgcgc cggcggcacc gccacgctgc ccgggacggc caccgccgcc
3147121 gcccccggga cggccgcgga agcccgttcc gggagcggca cccacgccgc caccccggta
3147181 gttgccgccg cccgcgtcgg aacggccagc gccgggcgca ccgggccggc ccccgggtcg
3147241 tggcgcacca ggacgtggtg gacgggcacc cccgacagct ccaccggggc gtggcggcat
3147301 gctgccgggc gaggcgcccg gacgtggaac cccgggccgg gcggtaccgg ggcggggagc
3147361 cggcggacgc gggatgggcc ggtcggcggg ttgcgccgac gagaacgggt tgttgccgac
3147421 gcgcggggtg cgaatccccg gcttcggcac cgggcccggc cgcgccccgg gagccatgcc
3147481 ggggtggggt gcctgagggc tgggcggcac tgcggtcgga ggctcgggtg cggcgggggt
3147541 agttggggag acgattgccg ccccgccgga atcggcggcc ttggcgggcg cggcagtcgc
3147601 cttgccgttg cctgcggcca tgtcgatcgc ggcgtccagc gccttgtcaa gggacttgtc
3147661 ggggcctttg ccgggggact tggcggtgcc tttcgccggg gcaggtttgc tgccaccgaa
3147721 cgattcacgc agccgacggg caaccggtgc ttccaccgtc gacgatgctg atttgacgaa
3147781 ttcgccctgc tcgctcagcc gggcgagaac ttccttgctg gttacaccga gttccttagc
3147841 caactcgtgt acgcgggcct tacctgctgc cactacatct cctgtccatg aggcgacagt
3147901 cgtgggccgc gcctcgggtt tagctatgac gcattgtcat cgggacttca cggtgtgctc
3147961 atgttctatt gctacctgtt ctgttgcccg gtggttcgag ctcgcctaga gactccaggt
3148021 actcgaccac tgcggatgtg tccggcgaac cggcgatgcg cagcgctctt gcgaaagccc
3148081 gccgccgaat cgcttgttgc gcgcactgcc gtagcggatg cagccacgca ccccgccccg
3148141 gcaggctggt cgctgtatca acgatcacgg cgtagttgcc gttcccggtc gacacagcca
3148201 ccactcgaag cagttcgacg gccaaccctc gctttcggca cccgacacac gtccgcaccg
3148261 gtccgcgggg attatccggg cgtcgatgcg ccgaggccga aggctcgcgc tggatcacgg
3148321 ctaagtgtag cgtcaccggg caagcccgat tgcccggcta tctgccgtgg gataacgcac
3148381 ggcgctagcg gtcgtgcgcc ataccgcggc tgactccggg ttcgggctga ccgggcgggg
3148441 gcggcggcgc atcgccgcga atatcgatac gccacccggt gagccgggca gccagccggg
3148501 cgttctgccc ttcctttccg attgccagcg acaattggaa atcgggcacc accacgcggg
3148561 cggcccgggc ggtctggtcg atcaccgaca ccgacaccac cttggccggc gacaacgcgt
3148621 tggcgacaaa acgcgccgga tcgtcgtcat agtcgatgat gtcgatcttc tccccggaca
3148681 gctcgctcat cacgttgcgg acccgttgcc ccatcggacc gatgcaagca cccttggcgt
3148741 tcaagccggc aacgttggac cgcacagcga tcttggagcg gtggccggcc tcccgggcca
3148801 ccgcgacgat ctccaccgat ccgtcggcga tctcggggac ttccagcgag aacagcttgc
3148861 gcaccagatt ggggtgcgtg cgcgacagcg taatcagcgg ctcgcgggca cctcgggtta
3148921 caccaactac gtagcagcgc agccggttgc catgttcata gctctccccc ggtacctgct
3148981 cagcggccgg gatcacaccc tcggaagcct tggtctcggt gccaatccgg acgacgacca
3149041 gaccgcgggc gttggcccgg ctatcgcgct ggatcactcc cgcaacgatc tcgccctcgc
3149101 gggtggagaa ctcgccgtag gtgcgctcgt tctcggcgtc gcggaatcgc tgcaacatca
3149161 cttggcgtgc cgtcgtggcg gcgatccggc cgaagccctc tggagtgtcg tcccactcgc
3149221 tgatgagatt gccagcctca tcggtctcac gggcgatcac ccgaacgaca ccggttttcc
3149281 ggtcgatctc gatgcgcgca tcggtctggt gaccttgggt gtgccggtag gcagtcaaca
3149341 gcgcggactt gatcgtttcg agcagttcat tgaccgagat accccggtcc acctcgatgg
3149401 catgcagagc agccatgtcg atgttcatgc tccggcctcc gtcccgcggg ccagccccat
3149461 ctcggaagac tgggccagtt ccaactccgc cggagccggt ggcgaaaact caacctggac
3149521 aacagctttc acaatctcag caagcgggat ctcacggact gcccagcccc ggtcttcccg
3149581 gatcaccaac gccaccgtgc cagcacgcat ctcgccgacc cggccggtca gtcgcgatcc
3149641 gtctgacaac accagctcaa ccttgcggcc tcgagcacgg cggaagtgct tttcgctggt
3149701 cagcgggcgt tccacaccgg gagagctgac ctcgagcagg tagcggcccc ggatcttgtt
3149761 cgcaccgtcc aggccgtcca gcaaagccga tgccctgcgc gacaatgcgg ctatcgtatc
3149821 caggtcgaga ggggcgtcac cgtcggcgat caccgctatc cgcggcgggc gggcccgcgc
3149881 atcgatgacc acgtcttcga tctcgtagcc ggcgcacgcg aaatctgcac cgagtagctc
3149941 gatcacctgc ctctgcgaag gtagcccggt ggtcacggcg agctcctcat cttgagttgt
3150001 ccggtcatct agcggaggcg ccgccagggc ggctcccagt gtcccgccgg cacgcagcag
3150061 ccggcgtagc taccaacgat acgccaggaa tcacgaatga cgccgtgatc acgccgttca
3150121 acgtctcgcc tgccttcgta gcggcgtctt tctgatggca ggatgttgct gtgcttagag
3150181 cagcaccagt catcaaccgg ctcacgaatc gacccatcag caggcggggt gtgctggccg
3150241 gtggcgccgc gctggccgca ctgggagtgg tgtccgcctg cggcgagtcc gcgcccaagg
3150301 cacccgcggt cgaagagctg cgctcgccgt tggaccaggc ccgacacgac ggtgcgctcg
3150361 cagctgccgc cgccacagcc atcgggatcc cgccgcaggt tgccgccgcg ctgaccgtcg
3150421 tcgccactca gcgaacctcg catgctcgag cgctggccac cgagatcgcc cgggccgcgg
3150481 gcaagctggt atccgctacg agcgaaacca gcagctccag tcccagccca accgatccgg
3150541 cggcaccgcc accagcggtg tccgacgtga tcgattcgct gcgcacgtca gcgggggaag
3150601 ccagtcgact agtggcgacg acatcgggct accgagcagg gttgctcgcc tccattgccg
3150661 cgtcctgcac cgcctcctat acggttgcgc tcgtgccttc aggcccgtcg atatgacctc
3150721 gtccgaaccc gcccacggtg ccacaccgaa gaggtccccc tccgagggga gcgccgacaa
3150781 cgcggcgctg tgcgatgcgc ttgccgtcga acacgccacc atttacggct acggcatcgt
3150841 ctccgcgctc tcgccccctg gtgtcaactt cttggtggcg gacgcgttga agcagcaccg
3150901 ccaccgccga gacgacgtga tcgtgatgct gtccgcgcgc ggagtcaccg ccccgatcgc
3150961 tgccgccggt taccagctgc ccatgcaggt cagcagcgcg gccgacgcgg cacgactagc
3151021 agtgcggatg gagaacgacg gggcaacggc ctggcgggcg gttgtcgagc atgccgagac
3151081 ggccgatgac cgggtgttcg cttcgacggc tctgaccgag agcgcggtga tggccacccg
3151141 ctggaacagg gtgctgggcg cctggcccat caccgcggcc tttccgggcg gggacgaata
3151201 gctacccggt gacggccgct gcgatatcgg tggccagcga ggcgccggca accagctcgc
3151261 gagtctgacc gctgaaccgg tcgcgcagct cgaccacgcc gtccgcccag ccgcgcccca
3151321 cgacaacgat ccagggcata cccaacagct cggcatcttt gaacttgacg ccgggcgatg
3151381 cctggcggtc gtccagcaac acctcaaccc ccagccgatc cagatcggcg gccagcgcgg
3151441 tcgccccggc gcgagcctgc gcgtccttgt tcgcgatcac caggtgaaca tcgaacggcg
3151501 cgaccgtcga cggccagcga aggcccagct cgtcgtggtg ctgctcggca acgacggcaa
3151561 ccaaccgaga cacaccgatg ccgtaggaac ccatggtcaa ccgcacaggc ttgccatcct
3151621 cgccgagcac gtcggcggtg aaggcgtcgg tgtatttgct ccccagctgg aagatgtgcc
3151681 caatttcgat accgcgcgcc atgaccagcg gaccggcgcc gtcgggagat ggatcgcctt
3151741 cgcgcacctc ggcggcctca atggtgccgt ctgcggtgaa gtcgcggccg gccaccaaac
3151801 cgacaacatg gcggccgggt tggtccgccc cggtgatcca gctggtgccg tcgactatcc
3151861 gcgggtcgac gagatagcgg acattgttct cccgcaacgc ctttggcccg atataaccct
3151921 taaccaggaa cgggtgcttg gcgaaatcat cgtcgtcgag caacgcgtag tcagccggtt
3151981 ccagcgctgc gcccaacctt ttgtcatcga cctcacggtc gccgggcacg ccgattgcca
3152041 gcagttcggt gtcccctccc ggctgtcgga ctttgattaa gacgttcttc agggtgtccg
3152101 cggcggtcac cgtgcggccg agatcggcct cgttggccca ggccaccagg ctggcgatgg
3152161 ttggggtgtc gccggtgtcg tggaccaccg cctcgggcag cccatcgatg ggcagggtgt
3152221 ccgggcgggc ggtgacaacc gcctcgacgt tggccgcata acccgactcg aggcaccgga
3152281 caaatgcgtc ctccccggac ggactctcag ccaagaactc ttcggacgca ctgccgccca
3152341 tcgccccgga cactgccgaa acgatgacat agcgcacctg aagtcggtca aatatgcgct
3152401 ggtaggcctc ccggtgagcg tggtaggccg ccttcagccc ggcggcgtcg atgtcaaagg
3152461 agtaggagtc cttcatgacg aactcccgag cgcgcaggat gccggcccgc ggccgcgcct
3152521 cgtcgcggta cttggtctgg atttggtaca gcgtgagcgg gaagtccttg taggagctgt
3152581 actcgccctt cacggtcagg gtgaacagct cttcgtgggt ggggcccagc aggtagtcgt
3152641 tgccgcggcg gtccttgagc cgaaacacgc tgtcgccgta ttgggtccac cggttggtcg
3152701 tctcgtacgg tgcccgcggc agcagggcag gaaataggat ctcctgtcca ccgatggcgt
3152761 tcatctcgtc gcggatgacc cgttctatgt tgcgcagcac tcgcaggccg agcggtaacc
3152821 agctgtacag cccgggcgcg acgggccgga tgtagccggc ccggatcagc agtttgtggc
3152881 tggccacttc ggcgtcggcg ggatcgtcgc gcagggtgcg caagaacaac tcggacatcc
3152941 gggtgatcac aggcggcaag cctaattcgc cgagcagacg caaaagcgcc caggtctgcc
3153001 cgaaaagggg agcttttatg actgctcggc gggaagggtt acagctcgcc ggcgtcgatc
3153061 gcttccttga cctcctgcgc atgggcaacc tgctgcggcg tatacccgat aaacagcgcc
3153121 ataccgccga cgatgatggc cgctccggcc acccacagca ggccgtaggt gtaggcgtgg
3153181 tcaagcgcgg ccaactgcac gtcgttcatg aacttcaccg gaccggtggt accgcccagg
3153241 tacagcgtgc gcgacgtgat cacagcctgg atgacggcga gcaccagcgg accgcccagg
3153301 ctctgcagca tcagcgcaat tgccgatacc ggaccgatct ggtcgaagcc gacgccagcg
3153361 atcgccgaca gagtcagcgg gacgacggcc atgccgatgc caatcccgcc gacgacgatc
3153421 ggcatgacca ggttggggaa gtagggcaca ccacggtgca tgaaaaatga gccgtacagc
3153481 atggcgccga atagcagata tccgccgccg atggtcaaca cccgtggcga aaaccgggac
3153541 accagctgcg aggacacacc taggccgatt cccatcgcga tgacgaacgg gatgaaacct
3153601 acgcccgcgc gtagcgcgct gtagcccaag atgtcctgca cgtacaggcc gatgcagacg
3153661 gtcaggctga acatgacgcc gccggccaac aggatcgcgc tgaacgtgac caaccggttg
3153721 cggtcgcgga acaagtggaa cggcacgacg gggttctcgg cagtgcgctc cacgatgaca
3153781 aacgcgacag cggccgccaa ggccaccagg cccgaaccga tggtaatgcc tgacatccag
3153841 cccttttcag gaccgatcga gaaggcgaaa accgccgcgg tgcatgccag cgtggccagt
3153901 atggccccgg tggcgtcgag cttcatccgt tctttgttgg tttcccgtag ggcggtgcgg
3153961 gccaggtaga tcatcaccag cccgatcggc acgttcacca ggaacgccca ccgccatgac
3154021 acctcggtca gtgctccgcc gaccaccagc cccatcaccg acccgatcgc ggtcatcgcg
3154081 gcgaacaccg ccgtcgcggc gttgcgggca ggtcccttgg ggaacgtggt cgccaccagc
3154141 gccagaccgg tcggagatgc gatggccgac cccacaccct gggacaaccg ggcgatcacc
3154201 aacgtcgcct cgtcccaggc gaccgcgcac agcaccgacg agatggtgaa tagcgcaacg
3154261 ccaacaatga aggtgcgttt gcgcccgatg gtgtcgccaa gccggccgcc gagcagcatc
3154321 agcccgccga aggtcagcac gtaggcggtg atcacccagc tgcggccggc atcagacaag
3154381 ctcagctcgt tttgaatctt aggtagcgcg acgatggcga cggtgctgtc catggtcgcc
3154441 agcagctgca tcccgccgat agcaataacc gcagcgataa agctgcgcga gggcagccaa
3154501 gtcgggtagt acctgctggg gcgctctgaa gcggtctcct ccgagcgcgg cgggcgcatc
3154561 ggggccggac ggtgtgggcg tccggctgtc cagttacgga ccgcccgctc tgtgtcgttg
3154621 agagccgtca tagcgggtta ccttacagta ttcttaagaa ttgtttaaac cccgaacgcc
3154681 gctcaggccg actacagccc cgatcacgat gatcgcggga ggtcggatcc ccgccgcgcg
3154741 gaccttctcc ggcgtgtcgg caagggtggc ccgcaacgtc tgttgagcgg cggtcgttcc
3154801 gtgttgaacc accagtaccg gcgtatccgc agttcggcca ccctttagca gaacgtcaac
3154861 gaaaagctcg atgcgttcga ccgccatcag caaaacgatg gtgcccgtca atgcagccaa
3154921 tgcatcccaa ttcactaacg attcgggatg accgggcgca agatggccac tgaccaccac
3154981 gaattcgtgg gtcatggccc ggtgagtgac tggaacgccc gccatagcgg gcacggctat
3155041 ggcactcgtc acacctggca ccacggtgac cgggattccg gcgtgggcac atgccagcac
3155101 ttcttcatag ccccgggcga acacgaaggg gtcgccccct ttgagacgga ccacaaagtt
3155161 gccggatctg gcccgttcga tcaggacagc gttgatcgcg tcctgggcca tggcccggcc
3155221 gtaagggatc ttggccgcgt cgatgacttc tacgtgcggc ggcagctcgg ccagcagttc
3155281 gggcggggcg agccggtcgg cgaccacgac atcggcctgg gcaagcagcc ggcgaccgcg
3155341 aaccgtgatc agttcgggat cgccgggacc gccgccgacc aacgccactc cgccgctgag
3155401 gacgtcggaa ctctgcgcag tgatgacgcc ctgctgcaac gcctcccgga ttgccgagcg
3155461 gatcgccgcc gaacggcggt gctcaccacc ggcgagcacc cccaccgaca ggcccgcata
3155521 gctgaatgac gccggggtca ccgccgtccc ctccaccgcg atatcggccc ggacgcaaaa
3155581 gatccgtcgg cgctccgcct cggcgacgac agccacgttc acccgcgcgt catcggtggc
3155641 cgcgatcgca taccaggcgc cgtcaaggtc gccgtcgcgg tagtcacgca ccgacaaggt
3155701 gatctggtcc atcgcctcga cggcgggggt gacgctgggg gcgatcacgt gcacgtccgc
3155761 gccactggcg atcagcaggg gtaaccggcg ctgggcgacc gtgcccccgc caaccacgac
3155821 gaccttcttg ccagccagcc gtaacccgac cagatagggg ttctcggtca cccgccaagc
3155881 ctagtggcga tcgcaagcgc ggggaccggg cgccgcgggt cgccaccatc agggccagtg
3155941 gcgatcgcaa gcgcggggac cgggcgccgc gggtcgccac catcagggcc agtggcgatc
3156001 gcaagcgcgg ggaccgggcg ccgcgggtcg ccaccatcag ggccagtggc gatcgcaagc
3156061 gcggggaccg ggcgccgcgg gtcgccaccc ctttggccgc gaatgtaacg ccactgcgaa
3156121 tttccggccc ggcttttcgc agtgccgtta cgctcgtgga gtattgcagg ccgcatgtgc
3156181 gacgaaacgc gccaccgcac cgggtgttgc ggccggatgg gtatgcaggt aggacgcgtg
3156241 cacgccgctg tgcaccgcgc cgtctcgcac gtcgtccacg tcttggccct ggtacaccca
3156301 cgcgggctga tagctatcgg cgaatgtgac tgcggttcgg tggaattcat gtccaaccac
3156361 gcgctcgccg acggagtaca gcgccgaatc aacaaccgcg acggcgtcgc gataacccag
3156421 cttgagatgc tgggtgaacc gcgccgatcc ggccaccaca ccgcacatcg ggtgtccgtc
3156481 gagttcagaa accagataga gcaggccggc acattcggca tgcaccgggg cgccggcagc
3156541 ggccagttcg ttgatctgcc gccggacggt gtcgttggcg gacaactcgg cggtgaactg
3156601 ctcggggaat ccgccgggca acaccaccgc gtccgtaccc tcgggcagag tttcgctgag
3156661 cgggtcgaac tcgaccactt cagccccggc ggcgcgcaac atctcggcgt gttcggcgta
3156721 gccgaaggta aacgcccttc cggccgcgat ggcaaccgtg gctggctggc gggcggtgtt
3156781 gccgacggca atcaccgggt cccatggcgg gtgggccgcc tggctcccgg cgcaggcgat
3156841 caccgcggcc agatcgacgt ggcgagcgac cacagcagtc atcgcctgca cggcgagccg
3156901 tgcgcgacgg ccgtactcga cggcggtaac cagacccaga taccttgtcg gcagctctag
3156961 ttcagctgtg cgtggaatgg cgcccaagac cgcgacaccg gcctggtcac acgcctgtcg
3157021 cagcacctgt tcatgtcggg ccgatccgac ccggttgagg atgacaccgg cgatccgagt
3157081 tgcggtgtcg aacgtggaaa agccgtgcag cagtgcggca acgctgtgac tctggccgcg
3157141 ggcatcgacc accaggatca ccggggcgcc aagcagagca gcgacgtgcg cggtggaccc
3157201 cgctgcgggc gcgcccccgg caggcccaat gcgcccgtcg aacagcccca gcaccccttc
3157261 gatcacggcg atgtccgcgc ccgcaactcc atgcgcgtac agggggccga taagccgctc
3157321 ccccaccagt accgggtcga gattgcggcc gggccgtccc gcggccaggg cgtgatagcc
3157381 ggggtcgata aaatccgggc ctaccttaaa cggcgcgacg gtgtgaccgg cctgccgcag
3157441 cgctccgatc aagcccgtcg cgatcgtggt cttaccgctg cccgacgcag gcgcggcgac
3157501 ggccaccgcg gatacccgca tcaccactcg atgcccttct gccccttgcg gcccgcatcc
3157561 atcgggtgct tcaccttggt catctcggtc accagatcgg cggccgcaac caaccgctgg
3157621 ggtgcgtctc gcccggtgat caccacatgc tgatggccag gccgggctcg caggacatcg
3157681 acgacttcgt cgacgtcgag ccaaccccac ttcagtgggt aggtgaactc gtccagcaga
3157741 tagaagtcgt gacgttgcgt ggccagccgg agcgcgatct cggcccaacc gtccgccgcc
3157801 gcggccgcac gatcgacgtc ggtgccggcc ttgcgagacg tacgtgtcca ggaccagccc
3157861 gcacccatct tgtgccactc caccgctccg ccgatcccgt gctggtcgtg cagccggccc
3157921 agttgacgaa acgccgcctc ctcacccact ttccacttag cgctcttgac aaactgaaac
3157981 accgcgatgt ccagaccagc gttccacgcc cgcaacgcca ttccgaacgc cgcggtcgat
3158041 tttcctttgc cttcaccggt gtgtaccgcc agtatcggca tgttgcgccg ggcccgggtg
3158101 gtcaggccat cgttgggcac tgcgagcgga ttgccctgcg gcatgtgtgg ttacctatcc
3158161 atcgtcaagc cacgccacgc acggcatgca ctagataatc cgcgtgcaac tgctccaacc
3158221 gaaccaccgg cgcacccagc tgacgagcca gttgcgctgc caaacccagc cgtacatacg
3158281 acgtttcgca gtccaccacc accgcggccg cgccctcggc gaccagcccg gcagccgcgg
3158341 ttcggctgcg gcccaacggg tccggcccgg cggtggcccg gccgtcggtc agcacgacca
3158401 ccagggggcg tcgggcgcgg tcgcgtacct tctcccggat gatcagcgca cgcgcggcca
3158461 gcagtccctc agccagcggg gtcttgccgc cggtgctgaa tcgggccagt cgccggccgg
3158521 cgatgtgcgc cgacgacgtc ggcgacagca acagcgttgc ctcgtgctgg cggaaggtga
3158581 tcaccgccac cttgtccctg cgctggtagg cgtcgcgcag cagcgacagg gtggcgccac
3158641 tgaccgcagc catccggtcc cgagcagcca tcgatccgga agcgtcgacg acgaagatca
3158701 ccagattgcc ttcgcgaccc tcgcggatgg cccggcgcac atcgtccggc cacgggcgca
3158761 acggcccggc tccgaacgca cgctcgccgg cggccagcag ggtagcgaac aggtgcagtc
3158821 catgtgcgtc ggggtcgctg acctcggcgg ccgccaccac actgcccgag gcgttgcggg
3158881 cccgagaccg tcgccccggc gcgcccgtgc cgacccccgg gacccgcagc gcgcgggtcc
3158941 ggaatatctt tgacggcggc gcgctcgggc gcggcgacga tcgcaagcgc ggcgaagccg
3159001 ggcgcggcgg gtcgtcgccc atcgagctcg gcgcaccagg ttctgtcgac ttcgagcgtg
3159061 agttcggttg tgaggcaggt tcattggctg actggccgcc cccgggcgga tcgggctcgg
3159121 gctctgggtc gacgctcgcc agcgccagcg cctcatccag ctggtcgcgg tcgatgccgt
3159181 gatcgtcgaa cgggtcgcga cgacgacgat gcggcaacgc cagttctgct gccgcccgga
3159241 tatcctgctc ctcaacggtg cggacaccac gccaggcggc gtgcgcggcg gcggtccggg
3159301 ccactaccag atcggcccgc atgccgtcca cgtcgaacgc cgcgcacaac gcagcgatgc
3159361 gccgcaactc gttgtcgccc aacaccacat cgtctaccgt ggcccgggcc gcggcaatcc
3159421 ggtgggccag ctccgcgtcg gcgtcggcat agcgtgcgac gaacgcatcc gggtcggctt
3159481 cgtaggccat ccgccggcgg atgacctgta cccgcacgtc gatgtcacgt gacgcctgca
3159541 cgtcgacggt cagcccgaac cggtccagca gctgcggacg cagttcgccc tcctccggat
3159601 tcatcgtgcc gatcagcacg aaacgggcct cgtgggaatg ggagatgccg tcgcgttcga
3159661 cgtgtacgcg tcccatggcg gcggcgtcga gcaggatgtc aaccaggtga tcatgcagca
3159721 gattgacctc gtcgacgtag agcacgccgc cgtgggcgcg agccagcagt cccggagaga
3159781 acgcgtgctc gccgtcgcgc atcacccgct gcagatccag cgagccaacc acccggtctt
3159841 cggtggcccc cagcggcagc tccacgaggc cggtctcggt gctcccggtc gcgaccgaca
3159901 acaacgcggc cagcccgcgc accgccgtcg atttcgccgt gcccttctcg ccacggatga
3159961 gcgccccacc gatctccggt cgcacggcac acaacaacaa cgcgagccgc agccgatcgt
3160021 gcccgacgat cgcgctgaac ggataaggct tcacggccgc tccacctgac cggagccggg
3160081 ccgcaacatg ggcacatgcg ggatgccgtc gtccaggaac tcgtcaccgt cgcggacgaa
3160141 gccgtgctgg gcatacatgg ccgtcaggta ggcctgtgca tcaatccgac aggggtagtc
3160201 gcccacctcg gccagtgccg cgcacagcag ccggttggag tggccctgtc cgcgggcgtc
3160261 gcgtttagtg cacagccggc cgatccggaa gaccttctca cccccggcgt gctcttccat
3160321 caggcgtagc gtgcacgtca cctctccgtc gggcgtttcc aaccagaaat gcctggtctc
3160381 ggcaagcagg tcacgcccgt ctagctccgg gtatgggcag gcctgttcga caacgaacac
3160441 ctccaccctc aacttgagca gctcgtaaag ggcccgggcg tcaaggtctt tggcccagac
3160501 gcggcgcagt gcttcggtca taagcgccgc tctcccccgc aagcgggcgg tacccccact
3160561 gtatcgtcgc cggcgcgggt catgcggcac ctaacttcag cgccttggtg ctccatgacc
3160621 acacctcgtc gaacagcgcg ggttcattcg acagctgcac ccccagcgac ggcaccattt
3160681 ctttgagcgt gggcagccag gattgatagc ggttggcaaa gcatttctgc agcacgtcca
3160741 gcatgatcgc caccgcggtc gaagcccctg gggagccgcc cagtagtccg gcaatactac
3160801 cgtcagcatc gccgatgacc gtcgtgccga actcgagcac cccgccgttg cgttcatctc
3160861 gccggatcac ctgtacccgc tgaccggcta tcgtcaactc ccagtccgaa tcgattgcgc
3160921 taggggcgaa ttcgcgcagc gcactgaccc gctcgggttc agagagacgc agctggctga
3160981 tcaagtagtt cagcagtctc cgctcggtga ggcccacgcc gagcacggac aacagattgt
3161041 ccggcctgat cgaccggggc aggtcgctga tctgcccgtg tttcaagaac ttcggcgacc
3161101 agccggcgta tggcccgaac accagccacg acttgccgtt gacaaaccgc agatccagat
3161161 gcaaggcgcc caacggcggg gcgcccggcg ccgggaagcc atataccttt gcccgatgcg
3161221 aggcggtgag cgccgggttc ccggcgcgca ggaaccgacc gccaatcggg aagccggcga
3161281 agcctttgac ctctttgatc ccggatttct gcagcaccgg caaggtgtca cccccggccc
3161341 cgacaaagac gaacttggtg ttcaacttgc gcttttcgcc ggtccggcgg ttgcacatgg
3161401 tgaccgtcca gctgccgtcg gattgccgcg agaggttgcg aacctcgtgc ccgaacaacg
3161461 cggtagtgcc attttgcacg caatagccga tgagttgttt ggcgagggca ccgaagtcga
3161521 cgtcggtgcc gtcggcggcc cagttgagcg ccaccggctc ggagaaggcc cgtttagcgg
3161581 ccatgaacgg cagccggcgg gcgaattcgt cgggactctc gatgaactcg gtgccggcga
3161641 acagcgggtt gccggccaac gccttttggc ggcgccgtag atactcgacg ccccgcgatc
3161701 catggacgaa actcacgtgc ggcacagggt tgaggaagct gcgcacgtcg gtgaggatgc
3161761 cgttttcggc cgcgtatgcc cagaactggc gggtgacctg gaattgctcg ttgacacgca
3161821 ccgctttggt gatgtcgatc gagccgtccg gcatttctgg ggtgtagttc atctcgcaca
3161881 gcgcggagtg cccggtgccg gcgttgttcc agggaccgct gctttcggcg gctaccgcgt
3161941 ccagccgttc gatcagggtg attgaccagt tcggttcgag ccgacgcagc agcaccccca
3162001 gcgtggcgct catgatgccc gcaccgatca gcacgacgtc ggttctggct aggtctgaca
3162061 ccggacggtt ggttccttcc ttggctgcgc cgctcccagg ttatcccgac gggtgttaac
3162121 acgatgacgt ccgcctcctg ggccagtaac cctgtgcagc gcggggcagc caacccaaga
3162181 caattacccc gaagcccaca atgtgcgtcc ctggccgcca tagaatccgc actatccgcc
3162241 cagtccggtt cttcttggga ggtaacgatg ttgtatgtag ttgcgtcacc cgacttgatg
3162301 accgcggcgg ctaccaatct ggcggagatt ggttcggcga tcagcacggc aaatggtgcg
3162361 gcggcactcc cgactgttga ggtggtggcc gcggccgccg acgaggtgtc cacgcagatc
3162421 gcggctctat tcggagcgca tgccaggagc taccaaaccc tcagcaccca ggcagcggcg
3162481 tttcatagtc ggtttgtgca ggcgttgacc acggccgcgg cttcctacgc cagcgtagag
3162541 gccgccaacg cgtcgccact tcaggttgcg ctagacgtga ttaatgcgcc cgcccagaca
3162601 ctgctcggac gtccgctaat tggtaacggc gccgacggat cgacaccggg gcaggccggc
3162661 gggcccggcg ggttgctgta cggcaacggc ggtaatggcg ccgccggtgg gcccaaccag
3162721 gccggcggcg ccggcggcaa cgccggcttg atcggcaacg gcggggcggg cggcgccggg
3162781 ggtgttggcg cggtcggcgg taaacgcggc acgggcggcc tgctattcgg caacggcggg
3162841 gccggcgggc aaggcgggct cggcctcgca ggtatcaacg gcggcagcgg cgggcaggga
3162901 ggccacggtg gcaacgccat cctgttcggc cagggcggtg ccggcgggcc aggtggcacc
3162961 ggcgccatgg gcgtcgccgg caccaatccc acccccatcg gcaccgcagc gcctggcagc
3163021 gacggcgtaa atcagattgg gaacggtggt aacacggacc tcaccggcgg cgccggtggc
3163081 gacggcaatg ccggcagcac caccgtgaac ggcggcaacg gcggtaccgg cggcgcagct
3163141 aggaactcat ctggtggtac cggtaactcc tttggtggtg ccggcggcgc cggaggcgac
3163201 ggcgccaacg gcggcgacgg tggcgctggc ggggaagccc tcaccgaagg cggtgccacc
3163261 gccgttagtg gtgctggtgg taagggaggt aacgccgagg cttccggcgg cgccggcggc
3163321 aacggcggca aaggtggctt tgctcaggcc accaccagcg tgaccggggg taacggcggt
3163381 aacggtggca atggccacga cagtaacgcg ccgggcggcg ctggcggcag cggtggcgtc
3163441 ggcggtgacg gcggccgtgg cggcctgctg gccggcaacg gcggcaccgg cggtgccggt
3163501 ggcaacggcg gtaccggtgg cgccggtgcc cccggcggtg ccggcggcgc cggcggcaaa
3163561 gccgacatcg ccaacagcct cggcgacaat gccaccgtaa ccgggggcaa tggcgggaca
3163621 ggcggagacg gcggcagcgc gctgggcacc gggggggctg ggggtgccgg aggtctaggt
3163681 ggtcacgggg gtgcaggcgg gctgctgatt ggcaacggcg gcgccggtgg cgctggcggc
3163741 ctcggcggtg cgggcggcgc cggcggtgcg ggcggtgagg gcggtgccgg cggcgccgga
3163801 ggcgaagcta ttcccggcgg ggcgtccacc aactccgccg gcggtgacgg aggggcgggc
3163861 ggtactggcg gcaatggcgg tgacggcggt gccggcggag cccccggcct cggtggcgcg
3163921 ggcggggccg gcggatggtt gatcggccag tcgggcagca ccggcggcgg tggcgccggc
3163981 ggtgccggtg gtgccggagg tgccggtggc gcgggcggca gcggcggtgc gggtggccat
3164041 ggcgacacta cctccggcaa gaacggttcg tctggcaccg cgggcttcga cggcaacccc
3164101 gggcagcccg gctgagcggc acaagatctg aacgcgctct aagctgaccc cgtgactggc
3164161 tgggtgcccg atgtgctgcc cggctattgg cagtgcacaa ttccgctcgg gccggatccc
3164221 gacgacgagg gcgacattgt cgcaaccctg gtcggccgcg gtccgcaaac agggaaagcc
3164281 cgcggagaca ccactggggc acaccacacg gtcctggcgg tgcacggcta caccgactac
3164341 ttcttccata ccgagctggc cgatcacttc gccaaccgtg gcttcgcgtt ctatgcactt
3164401 gacctgcgca aatgcggccg atcgcgagcg cccggccaga cgccgcactt catcaccgac
3164461 ctggcccgct atgacaccga actcgagcac tccctgtcca tcatcaacga gcagaaccgc
3164521 tcggcgaagg tcctggtata cggccactcc gccggcgggc tcatcgtgtc gctgtggctg
3164581 gaccggttgc gccagcgcgg cgagatcacc cgcgcggggg tcaccggcct ggtgctcaat
3164641 agcccgttcc tggatctgca aggcccggca atcctgcgcc tgccgctgac ctcggcgttc
3164701 ttcgccgcga tggcgcgaat gcgccccaag tgggtagccc ggccaccaaa agaaggcggt
3164761 tacggttgca cgctgcaccg ggactatgac ggagagttcg actacaacct gcaatggaaa
3164821 ccggtgggcg gtttcccggt caccttcggc tggattcatg ccagccgtcg tggccacgca
3164881 cggttacatc gcgggatcga cgtcggtgtg cccaacctga tcctgtgttc ggatcacacg
3164941 gtacgggaaa aggccgaccc ggcgaccctg caccgcggcg atgcggttct cgacgtcacc
3165001 catatcaccc gctgggccgg ctgcatcggc aaccgcagca ccgtcatcgc ggtggcggac
3165061 gccaaacacg atgtgttctt gtcgctgccg caaccgcgcc agatggctta tcgccgactg
3165121 gatctctggt tggacgacta cctcggcaca cacaacgaca ccgacgcttc ggcatcgtcg
3165181 gggaaagggt gatggcccct acaaatggaa acgtacgaca tcgcgatcat cggaaccggt
3165241 tcgggcaaca gcattctcga cgaacgctat gccagcaagc gggcggcgat ctgcgagcag
3165301 ggcaccttcg gcggcacctg cctcaatgtc gggtgcatcc ccacaaaaat gttcgtctac
3165361 gccgccgagg tggccaagac catccgaggc gcgtcgcgtt acggtatcga cgcgcacatc
3165421 gaccgggtgc gatgggacga cgtcgtctcg cgcgtcttcg ggcgcatcga tccgatcgcg
3165481 ctgagcggcg aggactatcg aaggtgtgcg cccaacatcg acgtgtaccg cacacacacc
3165541 cgtttcgggc cggttcaggc cgatggccgc tacctgttgc gcactgacgc gggtgaagag
3165601 ttcaccgccg agcaggtggt gatagccgcc ggatcgcggc cggtgattcc gccggccatc
3165661 ctcgcgtccg gcgtcgacta tcacaccagc gataccgtca tgcggatcgc cgagttgccg
3165721 gagcacatcg tgatcgtcgg aagcggcttc attgcagcgg aattcgcaca tgtgttttcc
3165781 gctctgggcg tacgggtcac cctggtgatc cggggcagct gcttactacg gcattgtgac
3165841 gacaccatct gcgaacggtt cacccgcatc gcatcgacca aatgggagct gcgcacccat
3165901 cgcaacgttg tggacggcca gcagcgcggc tcgggcgtcg cgctgcggct agacgatggt
3165961 tgcaccatca acgccgacct actgttggta gcgacaggcc gggtgtccaa cgccgacctg
3166021 ctggatgccg agcaggccgg tgtcgatgtc gaggacggcc gggtgatagt cgacgagtac
3166081 caacggactt cggcgcgtgg ggtttttgcg ctgggcgatg tctcgtcgcc gtacttgctc
3166141 aagcatgtcg ccaaccacga ggcccgcgtc gtgcagcaca atctgctctg cgactgggag
3166201 gacacccagt cgatgatcgt caccgaccac cgatacgtac cggctgcggt attcaccgat
3166261 cctcagatcg ctgccgtcgg actcactgaa aaccaagctg tggcaaaggg actcgatatt
3166321 tcggtcaaga tacaggacta tggtgacgtc gcgtacggct gggcgatgga ggacaccagt
3166381 ggaatcgtca agctcatcac cgagcgcggc tctgggcgct tactgggcgc acacatcatg
3166441 ggttaccagg catcctcgct catccaaccg ttgatccagg cgatgagctt tgggctgacc
3166501 gccgccgaaa tggcccgcgg ccagtactgg attcatccgg cgctgccgga ggtggtggaa
3166561 aacgcgctgc ttggcctgcg ttgaccgcaa cggcgagccg tcgtccggca agcgatttgc
3166621 atcccgtcag cgccttacct acagtcggga catcgcgttc tgccccgtgc tggaaggacc
3166681 gacatggcca gcagccagct cgacaggcag aggtcgcggt cggccaaaat gaaccgcgct
3166741 ctgacagcag cagaatggtg gcgtctgggc ctgatgttcg cggtgatcgt cgccttgcat
3166801 ctggttggct ggctcaccgt gacgctcttg gtggagcccg cgcggctcag cttgggcggc
3166861 aaggcattcg gcatcggcgt cgggctgacg gcgtacacgc tgggcttacg gcacgcgttc
3166921 gacgccgacc acatcgccgc catcgacaac accacccgca agctgatgag cgacggacac
3166981 cgaccccttg ccgtcgggtt cttcttttca ctgggccact ccacggtggt cttcgggctg
3167041 gcggtaatgc tggtgaccgg actcaaggct atcgtcggac cggtcgagaa cgactcctcg
3167101 acgctgcatc actacacagg cttgatcggt accagcattt ccggcgcgtt cctgtatttg
3167161 atcggcatcc tcaacgtcat cgtcctggtc ggcatcgtgc gtgtcttcgc ccacctgcgc
3167221 cgcggcgact acgacgaagc cgaactcgaa cagcagttgg acaaccgcgg actgctcatc
3167281 cggttcctcg gccgcttcac caagtcactc accaagtcct ggcatatgta cccggtcgga
3167341 tttttgttcg gtctcgggtt cgacaccgcc accgagatcg cgctgttggt gctggcggga
3167401 accagtgccg cggccggcct gccctggtat gccatcctgt gcctgcccgt cttgttcgcc
3167461 gccggcatgt gtctgctgga caccatcgac ggttcgttca tgaatttcgc gtacggctgg
3167521 gccttctcca gccccgtgcg caagatctac tacaacatca ccgtcaccgg actgtcggtg
3167581 gcagtcgcac tgttgattgg cagcgttgag ctgctgggcc tgatcgccaa ccagttgggt
3167641 tggcagggcc cgttctggga ctggcttggc ggcctcgacc tcaacaccgt cggcttcgtc
3167701 gtcgtcgcga tgttcgcgct cacctgggcc attgccctgc tggtctggca ctacggccgc
3167761 gttgaagagc ggtggacccc ggcgcccgac cgcacaactt gacctcgggc gatcaaccct
3167821 agggcggtgc cgccggaatc gagacggtag ccaagcgagc ggtcgacgtg ttggaaaaga
3167881 tcttcgccga gaacgatgtc cgcgcgaacg tcaaccgggc ggcgtttgag aacaacggga
3167941 tccgcgcgct ggacctgatg agctcaccgg ggtcggggaa gacgaccgtg ctgggcgccg
3168001 cgctcgacga gcacgccgac caattcgcaa tcggcgttat cgaaggcgac atcaccaccg
3168061 acctggacgc ggccaatggc cgcggcaccc aggtgtcgct gctgaacaac cagcatggct
3168121 tttgcgccga atgccacctc gacgcaccta tggtcaaccg cgccctagct ggtgcgcccg
3168181 acggagttcg acgtcggtaa gcgccaaggc gatggtctcc tcggtcaccg agggcaagga
3168241 caagccgctg atgtacccgg cgacgttccg ctcgagggat gtagtgctgc tcgacaagat
3168301 cgacttggtg ccctttctgg acgccgacgt ggacgcgtat atcgcgcatg tccgcgaggt
3168361 caacgcagcc gcgacgatcc tgccgaccag cacgcgcacc ggagccggca tggggtcctg
3168421 gtcatgagcc gccggaaacg gctcgtctca tcggctttca cggtgaggcc accgcagccg
3168481 aaatggacaa cgttgatcgt cttccgggcc tgacagcaat ccgactgtga aatgcactac
3168541 gcgacacgct aacccgttgc gcagttcaca ctcggggcgc gatcacagcg gagtgacata
3168601 ggccgagctg atcccaccgt cgaccaggaa cgtcgaagcg gtgatgaatg atgcgtcgtc
3168661 gctggctaaa aacgctaccg cagcagcaat ttcgtcgggc tcggcgaacc ggcccagcgg
3168721 cacatgcacc atgcggcgag cggcccgttc cgggttcttg gcgaaaagct cttgcagcag
3168781 tggggtgttc accggccccg ggcacaacgc gttgacccgg atgccctgcc gagcgaattg
3168841 cacgcccagt tcccgtgaca tagccagcac tccacccttg gaggcggtgt aggagatctg
3168901 cgacgttgcc gaacccatca ccgcaacgaa ggacgccgtg ttgacgatgg agcctttccc
3168961 agcaagcacc atgtggcgca gggccgcccg gcagcacaag tacaccgact tcaggttgac
3169021 gtcttgtacc cgttgccacg ccgcgagctc ggtgttttcg atcagattgt cctcgggtgg
3169081 tgagatgccg gcgttgttga acgcaatatc tatgcggccg taggtttcgg ctgctccgtc
3169141 gaacagcccg ttgacggcgt cctcatcgca aacgtcggtt ggcacaaaca agcctgatag
3169201 ttcgtcagcg gccgcaccac cggcctcgac gtcgacgtcg ccgaccacga tcgtggcgcc
3169261 ttccgcccgc atccgacggc cggcagccag gccaataccg ctgccaccgc ctgtgatcac
3169321 cgccacccgg ccggccagcc gttggctgag gtccatcaca tctcctcccc gacggcgatg
3169381 aacacatttt tggtttcggt gaactgcagc ggagcgtccg gccctagctc gcggcccaca
3169441 ccggactgct tgaaaccgcc aaacggggtg ttgaagcgca ccgacgagtg cgagtttacc
3169501 gacaggttgc cggattcgac cgcccgcgcc acccgcagcg cgcgggacag gtcatcggtc
3169561 cagatcgatc cggacagccc gtacgcggtg tcgttggcca ggctgatagc gtcggcctcg
3169621 tcgtcgaacg tcagcactac aaccaccggc ccgaagattt cgtcggtgac ggtgcggtcg
3169681 ccgcgtttgg gtgtgagaac ggttggtgga aaccaaaatc cgcgcccagc cggagccgta
3169741 ccccgaaacg ccaccggagc gtcgtcgggc acataaccgg cgaccttgtc acggtgtgcg
3169801 cgcgatacca gcggacccat ctcggtggcg cgtgatccgg ggtccccgac gacaatgctg
3169861 tgtaccgccg gctcgagcag ctccataaac cggtcgtaaa cgctgcgctg caccaggatt
3169921 cgacttcggg cacagcaatc ctgcccagcg ttgtcgaaga ccccggccgg cgcggtcgtc
3169981 gcggcgcgct ccaggtcgca gtcgtggaag acgatgttgg cgctcttgcc acccagttcc
3170041 aacgtcactc gtttgacttg agccgcggca ccggccatga cccgcttgcc gacttcggtg
3170101 gacccggtga acacgatctt gcgaatgtcg gggtgggtga cgaaccgctc cccgaccacc
3170161 gtgccctttc ccggcaacac ctgcagcagg tcttcgtcca gacccgcctc gacggccagc
3170221 tcaccgagcc gcatcgtggt cagcggcgtc agttcggcgg gtttgaccag caccgcgttg
3170281 ccggcggcca gcgccggcgc gatggcccag gacgcgatca ccatcgggaa attccatggc
3170341 gtgatcacac cgaccacgcc catcggttcg ttgaaagtga cgtccacccc gccggcaacg
3170401 ggaatctgcc tgccggacaa ccgttccggg ctggcggcat agaacgccaa cacgtcacgc
3170461 acgtggccgg cttcccactc ggccgacacg atcggatgtc cggaattggc tacctcgagc
3170521 gcggccagtt cgtcgaggtg ggcttgcacg gctgccgcga atgcgcgcag gccggccgcc
3170581 cgctgcgccg gtgccaaccg tgcccagcgc cgctgcgctg ctcgcgcgcg ttgcacggcg
3170641 tcgtccaccg cgttggcgtc ggtgtggtca actgaggcca gcacttcctc ggtggcggga
3170701 ttgatcagtt gcgtggtact catcgtggct ccgcttggct ctgccggccc gcgtatccgc
3170761 tggcggcgtc caccaacgcc ttaaacagcc gcagatcgtc caacgacttc tccggatgcc
3170821 actgcaccgc tagtacgaac gtgtccccag gtagctccag cgcctcgatt accccgtcga
3170881 catccaccgc actgaccacc aggccctcac cgacctggtc gatggcttgg tggtggtagc
3170941 acggcacgtc ggcggattcg ccgatcagct cggccaaccg ggtgcccgat gcggtgtgga
3171001 ccggcaacct ggtgaagacc ccgttgcccg cccgatgccc gctatggcca aggatgtcgg
3171061 gcaggtgctg gtgcagcgtg ccgccgagcg cgacgttgag cacctgggtg ccgcgacaga
3171121 tgcccaacac gggcatcccc cgctgaagcg cgccccgcaa tagcgcgaac tcccaagcgt
3171181 cgcggcccgg gcgagggtga tcggtggccg gatgcggctc ctggccataa gctgccgggt
3171241 ccaggtcgta gcccccggtg atcaccagag cgtgcaggct gtccagcacg cagccgacgc
3171301 tctcggggtc gaccggctgc ggcggcagca gtaccgcaac acccccggcc atggtgatgc
3171361 cttcgaagta atcggcgggc agataacccg caggaatatc ccaaaccccg gtgcgcacct
3171421 gctccagata agccgtcagg ccaaccaccg ggcgactcgc gcccagtggc gatcgcaagc
3171481 gcggcgaagc cgggcgcagc gggtcgccac catcggacac aggcgatcgc aagcgcggcg
3171541 aagccgggcg cagcgggtcg ccaccatcgg acacaggcga tcgcaagcgc ggcgaagccg
3171601 ggcgcagcgg gtcgccacca tcggacctag aggcgctcaa atccacgtat cctctcccaa
3171661 tcggtgaccg ccgcgttgaa cgccgccagc tccacacgcg cgttgttcag gtagtgcgcg
3171721 acaacatcct cgccgaacgc ctcgcgcacc agcgcagaat cctcgaacag caccgcggcg
3171781 tcggccagcg taaccggcag ccgttcgaca tcggcgcctt ggtaggcgtt gccgacacag
3171841 ggctcgggca gctgaaggcc ccgctcgata ccgtacaacc ctccagcaat gagagccgcc
3171901 accgccaggt actggttgac atcaccgccg ggaacccggc attcgacccg gatgttttgc
3171961 ccgtggccaa ccacccgcag ggcgcaggtg cgattgtcca gcccccaagc cagcgccgtc
3172021 ggcgcgaaac tgctatcggc aaatcgcttg taggagttaa tggtcggcgc atagcacagc
3172081 gtgaattcgc gcaacgtggc caactggccg gcgacgaagc tgcggaacat cgacgacatg
3172141 ccgtgcggcc cgttactgtc ggcaaacacc gcggagccat ccgtgccacg cagcgagaca
3172201 tggatgtgac agctattacc ttcgcgttca tcgtatttcg ccatgaacgt taggctcttg
3172261 ccgtgctggt cggcgatttc cttggcgccg ttcttgtaga tcgcatggtt gtcgcaggtg
3172321 accagcgcct cgtcgtaacg aaacccgatc tcctgctggc ccatgttgca ttcgcctttg
3172381 accgcctcga atcgcagacc cgcaccggcc atacccaacc ggatgtcgcg cagcaacggc
3172441 tccatccgcg aggatgccaa tatcgcgtag tcgatgttgt agtcgctggc cggggtcagc
3172501 ccgcgatacc cgctggccca tgcctggcga tacggctggt cgaacacgat gaactccagc
3172561 tcggtggcca catcggcgac cagtccgcgc gccttgagcc gatcgagctg acggcgcaga
3172621 atgctgcgcg gcgagacggc gacctcgctg ccgtcggccc agaccaggtc ggcgatcacc
3172681 agcgccgttc ccggtagcca aggaatcagc cgcagagtgg acaagtccgg cgtcatcacc
3172741 atatcgccgt agccggtgtc ccaactggcc atcgcatagc cgggcaccgt gttcaggtcg
3172801 acgtccacgg ccagcagata actgcagcac tcgacgccgc gggtggctat gtcgtcgacg
3172861 aaatgccggc ccgatatccg tttgccggcc agccggccct gcatgtcggt gaacgcgacg
3172921 atgacggtgt cgacgtcacc ggccgcgacc agtcgctcca actcggtcca cgccaacggc
3172981 ggcgaaccgg ggccggtcac cgcacttcct cccacaccat ggccgctagt caaccatcta
3173041 taggctccgg gcccacatgc tggctgtcgc gggcaccgcg aaccgccgga gccggcgagt
3173101 agacgcgaaa gaacatgatg ggcgctggtg cccatcatgt tcttttgcgc ctactcgcgc
3173161 tacagacagg tcaggatctc gacgccggta tcggtaacca gcagggtgtg ttcgaactgt
3173221 gcggtccact tgcggtcctt ggtgaccacc gtccaaccgt cgtcccagat ttcgtagtcc
3173281 agtgcgccca agttgatcat cggctcgatg gtgaaggtca tccccggctg catgatggtc
3173341 tcgacagcgg gctggtcgta gtgcaagacg accagcccgt tgtggaacgt cgtgccgatg
3173401 ccatgaccag tgaagtctcg aaccacgttg tacccgaacc gatttgcata cgactcgatg
3173461 acacgaccga taacggacaa cgcccgcccg ggcttgacgg tgttgatcgc acgcatggtc
3173521 gcttcgcggg tccggtcaac gagcaaccgg tgttcgtctg cgacatcgcc ggccggaaac
3173581 gtcgcgttgg tgtcaccgtg caccccaccg atgtaggcgg tgacgtcgat gttgacgatg
3173641 tcgccgtcgg tgatcaccgt cgagtcgggg attccatggc agatgacctc gttgagggac
3173701 gtgcagcacg acttcgggaa tcccttgtag cccagcgttg atgggtaggc gccgttgtcg
3173761 accaggtatt cgtgcgcgat ccggtcgagt tcgtcggtgg ttaccccggg cgcgaccgcc
3173821 ttgcccgcct cggccaacgc acctgcggcg atccggcctg ccacgcgcat cttctcgatg
3173881 acctcaggtg tctgcaccca cggctcgctg ccctcttggg cggccggttt gccgacgtat
3173941 tcggggcgcg cgatccagtt gggcaccggc cgtgtcgggg acagcacgcc gggggagagc
3174001 gcggtacgac taggcatccc gctagcttag ccgggcaaat tttggccgcg cccggctatc
3174061 agccccggtg tcggcgcagc agtgcgcgcc gcggtccctt gatgaccacc gacccgcaca
3174121 ccatccgacc ggtcaacacg acatgcggtg ttccttccgc cggtgcgtcc ttgcggcggt
3174181 cgctcgcgct acccacatag acctcgacgt cgtcgatcga cgcactggcg ccgttgggca
3174241 gccggacctc aagtgagccg aacatcatat cgagttcgat caccaccacc ggccccgcga
3174301 aacgggcctt gacgaggtcg agttcgattg accccagccg acgcaccagc gccagccggg
3174361 tgggcacgat ccattcgccg tggcgtttca gggagccggc ccagccgcgc agctccaccc
3174421 ggtcggccgc ggacgtgacg atcgcgccag gcctgggcag gtcaccgacc agcccatcca
3174481 gctcgcttcg cgtacacgcg aaggaaaccc gtgacgagcg ctgctcgaac tcgtcgatgt
3174541 tgataagccc gagcgccacg gcgttgtgca gtcgtcgcat tgtgccgttg cggtcggcgt
3174601 ccgagacccg caacgccacc atgtccccac cggtctccgt catggcccat tcccgagagt
3174661 tctggcacgg cttcaacggc gaacttcgcc taccccccgc aacttaccgc tgttgaaagg
3174721 ccgccgaaaa cctagcagtt taggtaatcc tttccgacga agagcgggag gcgttccggc
3174781 agcaagccgc agcccagcag atgtccctca gtaactggct gcgtcaagcg gggctcaggc
3174841 agctcgaggc acagcgacaa cgtcccctgc gcaccgccca ggaattgcgc gagttctttg
3174901 cgtcacggcc cgacgagaca ggggcagaac ctgattggca ggcgcatctg caggtgatgg
3174961 ctgaatcgcg ccgtcgcggc ctgccggcgc catgatcttc gtcgatacca acgtcttcat
3175021 gtatgcggtc ggtcgcgatc acccattgcg gatgcccgcc cgtgagttcc tcgagcacag
3175081 cctcgaacac caagaccgcc ttgtcacgtc agccgaggcc atgcaggaat tgctgaacgc
3175141 gtatgtgccc gtcgggcgga actcgacgct ggactcagca ttgaccttgg tgcgggcgct
3175201 gacggaaatc tggcccgtcg aggcggccga cgtcgcgcat gcgcgaaccc tgcaccaccg
3175261 ccaccccggt ctgggcgcgc gcgatctgct acacctggca tgctgccagc gtcgcggtgt
3175321 cacgcggatc aagacgttcg accacacact ggccagcgca ttccgatcat gacgcgtccg
3175381 tgtgggcgcg agcgtccgca gttgtacggc cctaacggcg tgtcgtcgta caaacgagga
3175441 ggggcgagcc gcgctacgcc aggtaccccg gcggcagcga ttcgaacatc accttggtca
3175501 tccgcaccgc gtattccgag ctaccgcccc cgacgatcag cgacgcaaat gccagatcgc
3175561 cacggtaccc ggcgaaccag gaatgcgatc cgcccgggaa ttcggcttcg ccggtcttac
3175621 cgaacacctc gccacagcca gcgatctcct tggcggtgcc attggtcacc accaaccgca
3175681 tcatgggccg cagcgcgtcg atcatcttct ggctgatcgg tgtggcatcg ccttcgacgg
3175741 ccgtcggccg gccggcgatc agctgtggaa ccggggtctt cccggcggct accgtcgccg
3175801 ccaccaaggc catgccgaac gggctggcca gcaccttgcc ctggccgaaa ccgtcctcgg
3175861 tgcgttcggc caggtccacc gtcggcggca ccgaaccggt caccgtggtg atgccgtcca
3175921 cctggtagtc aagcccgatc ccgtaccgcc gggccgcctg agtcagaccg cggggaggca
3175981 gcctgctgct cagctcggcg aaggtggtgt tgcaggaact ggcaaacgcg cgtgacatcg
3176041 gcaccacgcc cagatcaaag ccaccgtagt tgggaatggt gcgatgcccg atgtcgatct
3176101 ccccggggca acccagcagc gtctcagggg tagccaggtc acgctcgacg gccgcaccgg
3176161 cggtgatcat cttgaatgtc gacccgggtg gatatagacc ggtggtcgcg accggaccgt
3176221 ccgcatcggc cccggcgttc tgcgcgatcg ccaggatctc gccggtcgac ggcttgatca
3176281 cgacgatcat cgccttgccg ccccgggtgt tcaccgcgtg ttgcgcggcg ttttgcacga
3176341 cccgatccaa cgtgatcgaa accgacgacg caggtgatgg ggcgacctcg tgcagcaccg
3176401 agacgtcgac gccattttgg ttgacgctca ccacccgcca acccgccttg ccgtcgagtt
3176461 catcgacgac ggccttcttg acatcgttga ggaccgccgg cgcgaagtgc ttgtcggtcg
3176521 ggagcagctc ggcctgcggt gtgatcacca cgccaggcag ctgcccgatc gccgcggcca
3176581 cccggttgct gtcgtcggcg tgcaacgtga ccaggtccaa cggctgggtc gacgagctgg
3176641 cctgttcggc cagcagctgc ggatcattga gcgtgtcgtc gaaggggtgc agcgcgccca
3176701 ccaccgcgtg tgccgtgccg aagagctcgc ggccggcctg gccggcgtcc agcgagtagt
3176761 gatacagata gcccggcacc agcacatcgg tgccgccgac ttcgttcacc gaggcgcgcc
3176821 gcggcgggtc ggctcgtagc gcgaacgttt gatgttcgcc tagcttggga tgcaacccgc
3176881 tggtggtcca gcgaacgtgc caacgccctt cgtcgcgggc catcttcagc tggccgtcat
3176941 aggtccagat tcggtccttg ggcagatgcc agctgaagcg ataagcgacc gtaccggtgt
3177001 cctcggcgta cttggcgctg agaacctgcg catccaggtg ggcggcctgc agccccgccc
3177061 aggccgcgtt cagcgcttcg cgcgcctcgt tggggttgtc gctgagctgg gcggcggagg
3177121 cggtgtcacc gatggccagc gcggcgaaga acttttcggc cgccggaccg ggcccttggg
3177181 gacgcggggt gcagcccgac atggcgacga ccgcaagcag cagcaaacct gaggtggctg
3177241 aggctaatgt tgttttagtt accatcgttg ctgatgttaa gaactgtgac ggagacaccg
3177301 gccgcgacac accgagaccg aaccgttacg ccgagactag gtcgcgaatg gaacaccacc
3177361 gcgaaaatcg tggccagaaa tcgcaaccac gttacgctcg cgaccgctca atcgagcaag
3177421 gcgccgaccg caagcaccag caaacctgag acgccgcgca caaagtgcga aaccactgga
3177481 aggtgagccc taatttaggg ctgagcagga cctgtataac ggcctagtat ggcggtatgc
3177541 ggatactgcc gatttcgacg atcaagggca agctcaatga gttcgtcgac gcggtctcgt
3177601 cgacacagga ccagatcacc atcaccaaga acggtgcacc cgcagccgtt ctggtcggcg
3177661 ccgacgagtg ggaatcgttg caggagacgc tgtactggct ggcgcaaccc ggaatcaggg
3177721 agtcgatcgc tgaagccgac gccgacattg cctccggccg cacctacggc gaagacgaga
3177781 tccgcgccga attcggcgtc ccgcgacgcc cccactgagc ggtgccttac accgtgcggt
3177841 tcaccacaac cgcgcgtcga gacctccaca agctgccacc gcgcatcctc gcggcagtgg
3177901 tcgaattcgc gttcggcgat ctgtcgcgcg agcccctgcg ggtgggcaag ccccttcggc
3177961 gcgagttggc cggcacgttc agcgcgcgtc gcggaacgta ccgcctgctg taccggattg
3178021 acgacgagca cacaacggta gtgatcctgc gcgtcgatca ccgcgcggac atctaccgcc
3178081 gatagcaact caccgacggg cgctctgccg tccgacggca gccatgactg agatcggtcg
3178141 gccgggcggc tccgaaaaga cctgaacaga acctcaggat tcctatgctc ccaatgtggc
3178201 ggcaatcacg aagaagctaa tcctcggcca gatccgggaa gtggctgagg cgaacgacgg
3178261 ccgaccgccc ggctgtgagc gctttgccgc cgagaccgga attccagcaa gcgcgtggcg
3178321 tggacggtat tgctaaccca ttctttcaag accgacgatc ctgttggcat cgagaggtac
3178381 tggcagcgcc gacacttgcc agaccgcatc gccgtgcaca ggacgtcgtc agcgctgata
3178441 tgcccgcagc tcggcgctca gtccagcaac accgtcgcga acgtgccgat ctccttaaag
3178501 cccacccggg cgtaggcggc acgggccacc gtgttgaagc tgttcacata caggctggcg
3178561 atgcgcccgc tgccgacgat cactgcggcc aacgttgcgg taccagccgt gcccagaccg
3178621 ataccgcgcc actccggatg aacccagacc ccctggatct gcccgacggc cggagattgc
3178681 gatcccactt cggccttgaa gatcacttga ccgtgctcga atcgggccca cgcgcgtccg
3178741 gccgcgatga ggccggccac ccggcgacga tagccgcgac caccgtctcc gagccgaggg
3178801 tcgacgccga cttcgccgat gaacatgtcg acggcggcca ccaggtagga gtccagttcc
3178861 tcgggccgta cctggcgtac gccggtgtcg atagcgcagc tggggtgagt agccagggcc
3178921 atcagcggtt ggttgtcgcg gacatcccgc gccggacccc acaccggctc gagccgctgc
3178981 cacatcggca acaccaggtc ggccctgccg accagtgacg aacaccgtcg cggcgtgctc
3179041 atcgccacgt cggcgaacgc attcaggtcg atcggtccgc cgcgcagcgg gatgaggttg
3179101 gcaccggcga aacacaggga ttcgtgcgcg ccgcgtcggg tccacagctc cccgccaatc
3179161 gcattgggat cgatgccatg gtctgcgacc cgggcggcga ccatgcacga ttcgatcggg
3179221 tcgtcgtcga gtacccgcca cacggcggcg gcgtcacgca ccacggacac ttgccgctcg
3179281 ccgacaagcc gagagatggg cggagccgac atctgcgaac tccctttggt gggaactgac
3179341 ggccactgaa tgaaaagctg acccctatca gcttacggtc acaataggcg aaccgctcgg
3179401 tgtcgcgccc ggatcttgct cgcccatttc ggcggccagc cgcatcgcct cctcgatcag
3179461 cgtctcgacg atctgtgctt cgggcacggt cttgatcact tcgccccgta caaagatctg
3179521 acctttgccg ttgccggacg ccacgcccag gtcggcctca cgtgcttcac ccggaccatt
3179581 gacgacacac cccatcacgg ccacccgcaa cggcacatcg agaccatcca ggccggcggt
3179641 tacctcgttg gccagggtgt agacgtcgac ttgcgcgcga ccgcacgacg ggcaagacac
3179701 gatctcgagc gaacgcggcc gcaggttcaa cgactcgaga acctgattgc ccaccttgac
3179761 ttcctcgacc ggcggggccg acaacgacac ccggatggtg tcgcctatgc cccgcgacag
3179821 caacgcgccg aaggcaaccg cggacttgat ggtgccctgg aaagcagggc cggcctcggt
3179881 gacaccgagg tgcagtgggt agtcgcaccg tgcagcaagc agctcgtagg cggcgaccat
3179941 caccaccggg tcgttgtgct tgacgctgat cttgatgtca ccgaagccat gctcctcgaa
3180001 aagcgaagcc tcccacagcg ccgactcaac cagcgcctcg ggcgtggctt tgccatactt
3180061 ctccatgaac cgtttgtcca gcgaaccggc gttgacaccg attcggatcg ggatcccggc
3180121 cgcacccgcc gccttggcga cctcacccac ccggccgtca aactccttga tgttgcccgg
3180181 gttgacccgc accgcggcac atccagcgtc gatggcggcg aatatgtagc gcggctggaa
3180241 atgtatgtcc gcgactaccg ggatctggct gtgccgggcg atctcggcca gcgcgtcggc
3180301 gtcctcctgg cgcgggcagg ccacccgcac gatgtcgcat ccggccgcgg tcagctcggc
3180361 gatttgttgc aatgtcgagt tgacgtcgtg ggttttggtg gtgcacatcg attgcaccga
3180421 gaccggatgg tcactgccca cgccgacgtt gccgaccatc agctgacggg tggcgcgccg
3180481 gggagcgagc gtgggtgccg ggggctgcgg catgcccaag cctacagtca ctgaaaatcc
3180541 tttctaccta ctggaaaagc ctaatcgggt tgaccaggtc ggcggtgacg gtcaagagca
3180601 tgtacccgac gacaagaacc aagaccacat aggtcgccgg caagagtttg aggtaattca
3180661 ccggtgcggc cgccaccttg ccacgagccg accggaccat gttgcggatc ctctcgaaca
3180721 ccgcgacggc aatatggccg ccatcgaacg gcagcaacgg cagcaggttg atcgcagcca
3180781 ggatgaggtt cagctgggcc aagaagaacc agaacgccac ccacagccca tggtcgacgg
3180841 tgtcgccgcc gatgatgctg gcgcccacca cacttatcgg cgtctgcggg tcacgctgcc
3180901 cgccgccgat cgcccgcacc agcgcaccta ccttggtcgg gagggcggcc agcgccttgc
3180961 ccacctccac ggtcaggtcg ccggtgaccg cgaatgtggc cggcatggcg gagaacacgc
3181021 cgtagcgcac aggcccgacc cgggcggcgc ccaccccaat cgcaccgacc gttgccggct
3181081 ggagctcacc gccctgcccg ttagggatcc agcgttgggt ggattcgatg tccacgtagg
3181141 taacaatcgc ggtgccgtca cgctcgacaa cgatcgggac gctgccgtgt gacttgcgca
3181201 ccgcggcggc catctcgtcg aaactggaca ccggggtgtc accgaccttg accacgacgt
3181261 caccggagcg aattccggcc agcgccgccg gaccgggccc ggtgcactgc tcgagcttgc
3181321 cctggctcac ttcctgtgca acgcagccag tttcgccgat tacggccctg gttggcggat
3181381 gcaggttagg cagcccccag accagcgcga tggcatagat cagcaccagg cagatagcga
3181441 ggttcattcc gggcccggcg aataacactg cgacccgctt ccaggtggcc tgcttgtaca
3181501 tcgcacggtc acgttcgtcg gggtcgagtt cctcgaccgg ggtcatgccg gcgatgtcac
3181561 agaagccgcc cagcggaacg gctttgacac cgtattcggt ctcgccgcgc cgggtcgacc
3181621 acaacgtggg gccaaagccg acgaaatagc gacgtacctt catcccggtg cggcgcgcga
3181681 cccacatgtg accacattcg tgcagggcca ccgaaatcag gatcgcgagc gcgaacagca
3181741 caatgccggt aacaaacatc atcgaggtgt caggaccttt ctaacgtcga tgcgtgtcga
3181801 cccgctgcgc ccggcttcgc cgtgcttgcg atcgccaccg aagccatacc agataccgcg
3181861 cgctgcgctc gctcgcgggc ccagcgctgc gcgtcgagta cgtcatccac ggtagcgggt
3181921 tcgacggccc attggtcggc agcgtgcaac acgtcggcga tgatgccgac gatggccggg
3181981 aagccgatcc ggccagcaag gaacgccgct gctgcttctt cgttcgccgc attgtaaacc
3182041 gcggtcatgc agccaccggc tacgccggcc tgccgggcca actcgaccgc ggggaagacg
3182101 tcggtgtcca acggctcgaa ctcccagctc gacgcggtat ggaaatcaca ggcagcagcg
3182161 gcgccgctga cccgacgcgg ccagcccagc gctaacgaaa tcggtagctt catgtccggg
3182221 ggactggcct gggcgatcgt cgaaccgtcg atgaaggtga ccatcgaatg gatgatcgac
3182281 tgggggtgca ccacgacatc gatgcggtcg taggggatgc cgaacagcag gtgggtttcg
3182341 atgacctcaa gtcccttgtt gaccagcgac gccgaattca gcgtgttcat cgggcccatc
3182401 gaccacgtag gatgcgcgcc agcctgctcg ggggtgacat gctcgaggtc ggccgcggac
3182461 cagccccgaa acggccctcc cgaggccgtc agcaccagct tggcgacctc gtcgggagtg
3182521 ccgccgcgca ggcactgggc cagcgcggag tgttcggagt cgaccggcac gatctgaccg
3182581 ggccgcgccg cccgcagcac cagcgaacca ccggcgacca gcgattcctt gttggccagc
3182641 gccagccggg cacccgtctt gagcgcggcc aacgtcggtc gcaggcccaa cgcgccgacc
3182701 agcgcattga ggacgacgtc ggcctcggtc tgctcgacca gccgggtggc ggcgtcggat
3182761 ccgtggtagg ggatgtcgcc gacccgctgc gccgcgtgct cgtcagcgac ggcaatattg
3182821 gtcaccccgg tctgcgcacg ttgtcgcagc aacgtgtcca gatgggcgcc gccagcggcc
3182881 agcccgacta cctcgaaacg gtccggattg tcggcgatga cctgaagcgc ctgggtgccg
3182941 atcgagccgg tactgcccag caccaccacc cgcaaccggc cgtcagcgcg cccgtcggtc
3183001 gagttggtca cctcatcatt gtgcgccacc acctcgttgt caccgcgccg ccggatcacg
3183061 acgcgtccac cggtagccac acttccccgt ggaatgcaat cgtcttgatg cctgcgcttg
3183121 atgctaagat gccatgcgtg cgcacgacga tccgtatcga tgacgagctg taccgcgagg
3183181 tgaaagcaaa ggccgctcgt tccgggcgta ccgtggccgc ggttcttgaa gatgcggtgc
3183241 ggcgtggtct caacccgcct aagccgcagg ccgccggccg ttatcgagtc cagccgtcgg
3183301 gtaagggcgg cctgcggccc ggtgtcgatc tatcgtccaa cgccgcactt gccgaagcga
3183361 tgaacgacgg cgtgtcggtc gatgctgtgc gttgatgtca acgtgctcgt ttacgcgcat
3183421 cgggcagacc tacgggagca cgcggactat cggggtttgc ttgagcggct ggccaacgat
3183481 gacgagccgc tgggtctacc agatagcgtg ctcgccggct tcatccgggt ggttaccaac
3183541 cgccgcgtct tcaccgagcc gacgagccca caggacgcat ggcaggcagt cgacgcccta
3183601 ctcgcggcac ccgcagccat gcgacttcgg cctggcgagc gccactggat ggcctttcgg
3183661 cagttagcgt ccgatgttga tgcgaacggc aacgacattg cggacgcgca cctggccgcc
3183721 tacgcgctag agaacaacgc aacctggttg agcgccgacc gcggctttgc ccgtttccgt
3183781 cgactgcgct ggcgtcatcc gttggacggt cagacccatc tataaccggc cccactccga
3183841 atcactggtg tccacccagg aggacggcgt tcaacgccgc cgcagaagca aaggaatcga
3183901 agcgatgatc aacgttcagg ccaaaccggc cgcagcagcg agcctcgcag ccatcgcgat
3183961 tgcgttctta gcgggttgtt cgagcaccaa acccgtgtcg caagacacca gcccgaaacc
3184021 ggcgaccagc ccggcggcgc ccgttaccac ggcggcaatg gctgaccccg cagcggacct
3184081 gattggtcgt gggtgcgcgc aatacgcggc gcaaaatccc accggtcccg gatcggtggc
3184141 cggaatggcg caagacccgg tcgctaccgc ggcttccaac aacccgatgc tcagtaccct
3184201 gacctcggct ctgtcgggca agctgaaccc ggatgtgaat ctggtcgaca ccctcaacgg
3184261 cggcgagtac accgttttcg cccccaccaa cgccgcattc gacaagctgc cggcggccac
3184321 tatcgatcaa ctcaagactg acgccaagct gctcagcagc atcctgacct accacgtgat
3184381 agccggccag gcgagtccga gcaggatcga cggcacccat cagaccctgc aaggtgccga
3184441 cctgacggtg ataggcgccc gcgacgacct catggtcaac aacgccggtt tggtatgtgg
3184501 cggagttcac accgccaacg cgacggtgta catgatcgat acggtgctga tgcccccggc
3184561 acagtaacgt tcggcgcggt caaggcgagg cagcccgtgt aggcggtttg cctcgctcat
3184621 ccggcggctt cgtgccgata gatcacgtga tatcccaagc gcatgacggt gacaccgcgc
3184681 ccagcgcaag ccgatccccg cagcatgcct gctgaagtcg cgtctcgcga actgcgcaac
3184741 aacaccgccg ggctgctacg gcgcgtgcag gccggcgaag acatcaccat cactgccaac
3184801 ggcaaacccg ttgcgctgct gaccgcaggc agcccgcacg gcgccgatgg ttgagtcgag
3184861 acgagctgct gcggcggctt cggcatacgc aagcagatgc gggattgcac ccgcgacctc
3184921 gcaacgctca ctggcgacac caccgacgat ctcggtcccg tccggtgagg gccgctgccg
3184981 ttgccacgtc gcaaggggtg ccggtcgtga cccacgacgg cgacttcgac gccgtcgatg
3185041 gtgtggccga tgtggctatc attcgcatct gacgggtggc gagttcgacg tgaaccgact
3185101 ctgtcaacag cgctcgcgtg agcggtcctg ccaactcgtt gccgtcccgg cagatccaag
3185161 acctaaacgg caacgaataa ccgatgtgtt gaccctcgca ctagtcggct tcctcggcgg
3185221 cctcatcacc ggaatatcac catgcattct gccggtcctg ccagtaatct tcttctccgg
3185281 cgcgcagagc gtcgatgcag cgcaggtggc gaaacccgaa ggcgccgtag cagtccggcg
3185341 caaacgtgcg ctatcagcga cattgcggcc ctaccgggtg atcggtggtc tggtgctcag
3185401 tttcggcatg gtcaccctgc tcggctcggc attgctgtca gtgctgcatc taccgcagga
3185461 cgccatccgc tgggccgcac tggtcgcctt ggtggcaatc ggcgccggcc tcattttccc
3185521 gcggtttgaa caacttctgg aaaaaccgtt ctcccgtatt ccgcagaagc aaatcgtcac
3185581 tcgcagcaac ggtttcgggc tgggtctagc cctgggcgtg ttgtatgtcc cctgcgccgg
3185641 cccgattcta gctgcgatcg tcgtggccgg ggctactgcc accatcgggt tgggaaccgt
3185701 cgtgctcacc gcgacattcg cactcggagc cgcgttgccg ttgttgttct tcgccctcgc
3185761 cggccaacgg atagctgagc gggtgggcgc ttttcggcgc cgccagcgtg agatcaggat
3185821 cgccaccggt tccgtgacga tcctgctggc ggtggcgttg gtgttcgatc tgccggccgc
3185881 gctgcagcgg gctattcctg actacaccgc atcgctgcag cagcagatca gcaccggcac
3185941 ggagatacgg gaacaactga accttggcgg catcgtcaac gcccagaacg cacagctgtc
3186001 gaattgcagc gacggggccg cacaactcga aagctgcggc actgcaccag atctcaaagg
3186061 catcaccggc tggctcaaca cgcccggcaa caagccgatc gacctgaaat cattgcgtgg
3186121 caaggtggtg ctgattgact tttgggccta ctcctgcatt aactgccaac gggccatccc
3186181 ccacgtcgtc ggttggtatc aggcctacaa agacagtggt ttggcggtca tcggcgtgca
3186241 cacccccgag tacgctttcg agaaggtccc gggcaacgtc gccaaaggcg cggccaatct
3186301 gggcatcagc tatccgattg cgctcgacaa caactacgcc acttggacca actaccggaa
3186361 tcgctattgg cccgccgagt atctgatcga cgctaccggg acggtgcggc acatcaagtt
3186421 cggagaaggc gattacaacg tcaccgagac gttggtcagg cagttgctca acgatgccaa
3186481 gcccggcgtc aaactccccc agcccagcag caccaccacg cccgacctta ccccgcgggc
3186541 cgcacttact cccgagacgt acttcggagt cggcaaggtg gtcaactacg gcggcggcgg
3186601 cgcatatgac gaagggtcgg ccgtgtttga ctacccgccc agtttggcag ccaacagctt
3186661 tgcactgcgc ggccggtggg cgctggacta tcagggtgcc acgtccgacg gcaacgacgc
3186721 cgctatcaaa ttgaattacc acgccaaaga cgtctacatc gttgtcggtg gcaccggcac
3186781 cctcacggtc gtgagggacg gaaagccagc cacactaccg atcagcgggc cgccgaccac
3186841 ccatcaggtg gtcgccggct atcggctggc gtccgaaaca cttgaggtgc ggcccagcaa
3186901 ggggctacag gttttttcct tcacctacgg atgaatatcc atccaagacc cggacggctc
3186961 cgaagaaatc atgtcggggg tagcgagacg gcacaagccg ccgtctccgg cagcgaagga
3187021 gtgaacggca tgaaggtaaa gaacacaatt gcggcaacca gtttcgcggc ggccggcctg
3187081 gcggctctgg cggtggctgt ctcaccgccg gcggccgcag gcgatctggt gggcccgggc
3187141 tgcgcggaat acgcggcagc caatcccact gggccggcct cggtgcaggg aatgtcgcag
3187201 gacccggtcg cggtggcggc ctcgaacaat ccggagttga caacgctgac ggctgcactg
3187261 tcgggccagc tcaatccgca agtaaacctg gtggacaccc tcaacagcgg tcagtacacg
3187321 gtgttcgcac cgaccaacgc ggcatttagc aagctgccgg catccacgat cgacgagctc
3187381 aagaccaatt cgtcactgct gaccagcatc ctgacctacc acgtagtggc cggccaaacc
3187441 agcccggcca acgtcgtcgg cacccgtcag accctccagg gcgccagcgt gacggtgacc
3187501 ggtcagggta acagcctcaa ggtcggtaac gccgacgtcg tctgtggtgg ggtgtctacc
3187561 gccaacgcga cggtgtacat gattgacagc gtgctaatgc ctccggcgta atcgtccgcg
3187621 gaggccgccg acccgcccga gagcgactga gcatgtgcca gaatgttcgg gcagtgggag
3187681 ttcgacgtca gtccaaccgg aggaatcgcc gtggcaagta ccgaggtgga gcacttcgcc
3187741 ggctcgcaac atgaggtcga caccgccgag gttccatctg cagcgtgggg gtggagccgg
3187801 atcgatcacc gcacctggca catcgtcggc ctgtgcatct tcggcttcct gctggcgatg
3187861 ctgcggggca accacgtcgg ccacgtcgag gactggttcc tgatcacgtt tgccgcagtc
3187921 gtgctgttcg tcttggcgcg cgacttgtgg ggccgacgac gcggctggat cagatagcca
3187981 gcacaccgtt cggtgtgccc gacccggtca gcgccgcacc cgccgaaacc aggtaccggc
3188041 gaaggcaccg accaccagca caaccagcaa caccgcccaa ggccatgcac cgtgctggtt
3188101 aacccagcca gccagggcac cttgcaggcg gccggccgcg gcaatcaccg catcctgggg
3188161 attcgccccg acaccggcaa tcaggcgcag ctcgtagaga ccgtagtaac ccacgtacag
3188221 cccgaccacc accagcagcg cgccactgat ccggttgacg aacggcaaga ttcgccgtag
3188281 gcggtcggcc agcgccgagc tcgcggtcgc ggccgcgacg gcaagcacgc cgacaacgag
3188341 ggtcaggccc gcgacataag ccagatagat cgctacgctc ccgacgaccg aaccgccccg
3188401 caggcctgcc ccggtaaccg cgagaaacgg cccgatggtg catgacagcg aagcaaccgc
3188461 atagctgatg ccgtagccat acatggaacc cagccgtacc gttggagccc aacgcacgcc
3188521 gagggatcgg ggcgtcaacg ccgtcagccc tcgtcccaac agcagccacc cgccgagggc
3188581 gatgagcgcc agaccgatca gcaccgtggc atagggcagg tatcgctgca ccgccgtggc
3188641 cgcggaaatg gtcagggctc cgaagatgcc gaacaccgtc aagaagccca gcgccatccc
3188701 gaccgtggcg gctgccgctc ggcccactgc gctaagcggc cccgtccggc ccgccgaatc
3188761 ctgcccatac accaccaaca gcaggtaggc cggcaacatg gcaaacccgc atgggttcag
3188821 cgcagccacc aacccggcgg cgaacgccaa accgatcagc gcctcgttca ccgggtcagg
3188881 acgtcagcgc agccacccgg ccggacagct cgtcctgaga catggccgcg gtggggttgt
3188941 tgacgaacgt cgatgtgccg tccgcgcgat agaacacaaa tgccggttgc caaggcacgt
3189001 tgtagcgggc ccagatcaca ccatcggcgt cattgaggtt ggtgaaattc aggttgtact
3189061 tcgagacaaa gctctgcatc gccccgacgt cggcgcgggt ggcgattccg acgaaggtga
3189121 ccgccggatt agcggccgct acctggctga ggctgggggc ttctgcgttg cagaacgggc
3189181 accacggcgt ccagaaccac aacaccgccg gcttgccttg caggcttgcg ccatcgaagg
3189241 gagcaccgct gagcgtggtt gcggtgaact gcagacgttc atcggctgcc accgctcgcg
3189301 gtgtattggc cagaccgaac atcaggacaa ccgcgatagc aacggccaca atgccgtccg
3189361 caaacgcctt gatcggggac accaggcgaa gactcatgac agacctcact tgttcgtgtt
3189421 ttgacctaat gacgtaatac gctccgtgac ggttcagtac atcccggcgc cccctgcgct
3189481 cgcggccagc tgtccgcagc gctggctgat tcgcctgcgc tccagctacc cgcctacggc
3189541 ggccagctgt ccgcagcgct ggctgattcg cctgcgctct agctacccgc ctacggcggc
3189601 cagctgtccg caggcggcgc tgatctcccg cccacgggtg tctcgtaccg tgcaggaaac
3189661 tcctttcgcc cgaacccgtt tgacgaattc acgctcaacc ggcttggggc tggcatccca
3189721 atcactgccc ggagtcgggt tcagcgggat caggttcacg tgcgccaacg gcccgagaac
3189781 acgatgcagt cgctttccca gcaagtcggc ccgccacggt tggtcgttga catcacggat
3189841 cagcgcgtac tcaatagaca cccgtcgccc ggtcacattg gcgtagtacc gggccgcatc
3189901 gagcgcttcg ctgatcctcc accggttgtt gaccggaact agtgtatcgc gcaacccgtc
3189961 gtcgggggcg tgcagcgaca gcgccagggt cacgccgagc cgcgcgtcgg caaggttgcg
3190021 gatagcaggg gccagaccca ccgtcgacac cgtcaccgcg cgggccgaaa tcccgaaacc
3190081 ggacggcggc cgcgcggtaa tgcgctgaac tgcggccaac accctggcgt agttggccag
3190141 cggctccccc catacccatg aacaccacat tcgacaaccg atcgccgaag tcgtcgcgca
3190201 acgccgcggc gccggcacgc acctgctcga ggatctccgc cgtcgatagg ttgcgagtca
3190261 atccgccctg gccagtggca cagaacgggc aagccatgcc gcagccggcc tgcgaggaaa
3190321 tgcagaccgt gttgcgccgc ggatagcgca tcagcaccga ttcgaacatg gtaccgtcga
3190381 cggcccgcca caacgtcttt cgagtctggc cggcatcgca ggtgatgtcg gcggacgcgg
3190441 taagcaagtt cgggaacatc gctccggcga tccggtcgcg aacggccgcc ggaaggtcgg
3190501 tcatctgacg cggatcggcg atcagccgac cgtagtactg gtgtgcaagc tgcttggccc
3190561 gaaacgccgg cagccccagc tccgcgacgg cagacgctcg gcccgccgcg tcgagatcgg
3190621 ccaggtgccg cggcggccga cccggacgcg gctcatcgaa catcaactcg gggaccatga
3190681 cctgtccagt atcgccgttg tcagggcagc agtgtgagga ctatccaggc cgccaccgcg
3190741 gaaggcagta tgccgtcgag ccggtccatc agaccgccgt ggccgggtag caggcggccc
3190801 atgtctttga tgccgaggtc acgtttgacc tgcgactcca ccaggtcgcc cagcgcggtg
3190861 gtgagcacga aaagcacgcc gagcagtgca ccaatccacg gcgttttgcc gaccaggaaa
3190921 gtcgcggtga tgatcgttgc ggtgatcccg cacaccagcg aaccggcaaa gccctcccac
3190981 gacttcttcg ggctgatcgt cggaaccatc ggatgcttgc caaacagcac ccccacggcg
3191041 tagccgccga catcggaagc gatgaccgcg atcatcatgc agaacaccca tcccgagcca
3191101 ttttccgggt agaccagcat tgcgccgaaa gagcagaaca atgggaccca cacggccagg
3191161 aagaccgtgg ccgagacgtc ggacaagtag tttcccggcg acggtgcacc gccggtcgtc
3191221 gggcgcgtca cgctgtcctg catgaacagt cgccaaatca tgcagacaac gaccatgcca
3191281 ccaaagcccg ccaatgcgcc gaccgcgccg aacggccagg tcagccacac cgcggcctgc
3191341 ccgccaatca gcaacgggat aaccgggatg agatagcccg cttcccgcaa cctccgcacc
3191401 acctcatggg tagcgaccaa ggtggcgacg gccacgatgg caacccaaac gcgcggaacg
3191461 aacaccagca ccgcgatgag gactaggcct atggaaaggc ccaccacgat cgctgcgcgc
3191521 aaatcacggc cggcgcggga cgtttcggtc gccggctgct gtttagcacc acgcgccggc
3191581 tgctcggcgg ggtttccggt gccggcatcg ttggttgtca cggattttgt tgctgagcgg
3191641 ccgctagacc tccagcagct cgccttcttt gtgtttaacc agctcatcaa tttgggtgac
3191701 gtattggtgc gtggtcttgt cgagatcctt ttctgcgcga ccgacctcat cctcgccggc
3191761 ctcgccttcc ttacggatgc gatggagttc ctccatcgct ttgcgacgga tattacgcac
3191821 cgaaaccttg gcctcctccc ccttatgctt tgcctgtttg accagctctc gccgacgttc
3191881 ttcggtgagc tgcggtacgg ccacgcgaat aagggcgccg tcgttggtgg gattcactcc
3191941 aaggtcggag ttgcgaattg cagtctcgat agcgcgcaac tgattggctt catacggctt
3192001 tatcacgact agccgcgcct cggggacatt gatgctggcc agttgcgtga tcggggtggc
3192061 cgcaccgtag tagtcgatgg tgatccgaga gaacatgcca gggttggcgc ggccggtacg
3192121 gatagttgac aggtcgtcac gtgccaccgc cacagccttc tccattttct cttcggcgtc
3192181 gaagagagcc tcatcaatca tctgcgccgc tcctcctcat cgctgcgctc tgcatcgtcg
3192241 ccggcgccaa ccatctgcgc cgctcctcct catcgctgcg ctctgcatcg tcgccggcgc
3192301 caaccatctg cgccgctcct cctcatcgct gcgctctgca tcgtcgccgg cgcgaagcag
3192361 cgcgtagtcc ccttaggtgg tgaccagcgt tccgatcttc tcaccccgaa cagcacgggc
3192421 gatattgcca tcggtcagca ggttgaacac caggatcggc atgccattgt ccatgcaaag
3192481 gctgaacgcg gtggcgtcgg ctactcgcag cccgcggtcg aggacctcac gatgactgac
3192541 ggcggtgagc agttcggcct cggggttcac ccgcggatcc tcagcaaaca caccgtcgac
3192601 cgctttggcc atcaagacca cgtcggcacc gatctccagc gcacgctgcg ctgcggtggt
3192661 atccgtcgaa aagtacggca gccccatgcc ggcaccgaag atcaccaccc gtcccttctc
3192721 caggtggcgg acggcccgca acggcaggta cggttcggcc acctggccca tggtgatcgc
3192781 ggtctggact cgggtaacga tgccttcctt ctccaggaag tcttgcagtg caaggctgtt
3192841 catgacagtg ccgagcattc ccatatagtc cgacctggtg cgctccatac cgagctgctg
3192901 cagctgtgcg ccccggaaaa agttgccgcc gccgatcacg acggcgatct ggacgccgcc
3192961 gcgcaccaca tcggcgatct ggcgggccac ctgcgcgacg acatcgggat ccagcccgac
3193021 ctggcctccg ccgaacattt ccccgccgag cttgagcaac actcgcgagt acccggacag
3193081 ctgagccgcc gacgcggcgc cagtgctcgc aggctccggc ttcgaagccg gcgcgccggc
3193141 gacatcgggc tctgtcatct gactcctcgc acgacagtgc catcccggca ccaccaggac
3193201 ggcatctcac atcctgcctc aatagccgcg ctccggcgtg ggcggggtgc gttagtcacg
3193261 caacaacgag gggccggccg aggccaggcc cgtcgactat ctcaaggtgt gagcatcgct
3193321 cgagcaacaa agttggaata gttctgttct gaaccgggta cccaggggta ccggcagaca
3193381 tctccgcgag ggatgcctac gggccccacg acggggaagt ggcaccctca tgaagtttgg
3193441 agatatctct tggaagttct acttcttacc gatgaagccg atcttgaatc ggctctgccg
3193501 gagctggagt cgttcgcgca gtcggtgcag cgcgcaccgc tggacgaccc gggcgcggcc
3193561 aagggtgcgg acgccgatgt cgcgatcatt gacgcgcgcg ccgacttggc ggccgctcgc
3193621 cgggtgtgcc gccggctgac gactagcgca ccagcccttg ccgtggtggc tgttgttgcg
3193681 ccggccaact ttgtggcagt ggacggcgat tggatattcg atgacgtgct gttgaacgcg
3193741 gccggcgggg ccgagctgca ggcacggttg cggttggcga tcacacgtcg acggagcacg
3193801 ctagcgggca cactgcaatt cggggacctc gtccttcacc cagccagcta caccgcgtcg
3193861 ctgggcgacc gggacctggg gctgacgctc accgaattca aactcatgaa tttccttgtg
3193921 cagcatgccg gtcgggcgtt cacccggact cggctcatgc gtgaggtgtg gggctatgag
3193981 tgccatggtc gcattcgtac cgtcgatgtt cacgtacgac gactgcgcgc aaagctcgga
3194041 gccgagcacg aatcgatgat cgacaccgtt cgcggtgtgg gttatatggc ggtgacgcca
3194101 ccgcagccgc gctggatcat cagcgaatcg atactaaacc gttgcaagtg agtgatcttt
3194161 agtggtcact tgacttgcac cccgtctcgg ggttgttcgc cggccgggtg gccggttgcc
3194221 ttccgcgctt cacggccacc cgccgggcca ggcccggtct tacggtcggc tccacgcttg
3194281 acggcggccc caactgggcc gacgacgcta ggtggttcct cgtagcgtgc gaggttgatc
3194341 gcggcgttgt cgtcacgttg gtgcgtgatc gaacagccgt cgcattgcca tttttcgtcc
3194401 cagccgatgt cttgcacatg ccggcaggca tggcaggttt tcgacgatgg gaaccagcgg
3194461 tcggcgacca ccagactcga tccgtaccag cctgtcttgt aggacaggtg acggcgcggg
3194521 gttgccaggg ctgcatcaga cagtgcgcgc cgtctggcgc gcgcccccgg cagtcccttt
3194581 tgccgcagca ttcccgccgc atccagacct tcgacaacga tacggccgtg ggttttggcc
3194641 aatcgtgttg tcagcacgtg caggtggtgg gtacggacat cgttgacccg acggtgcagc
3194701 cgggacagtt cggtggtgcg ctcacagtag cggcgtgagc ctttcgtgca gcgtgagcgt
3194761 gcgcggctga cgcggcgcaa cccgcgcaac gcagcatcaa gcgggcgagg attcggcact
3194821 tgttcaagca ccgtgccctc agcgtctgca acagtggcca aacgccgcac accaacgtcg
3194881 acacccaccc gtgaatcagg aagcgccaca cgccgctgtt gggggcgttg gacgagcacc
3194941 cgcacgctcg catccaggcg ggtgccgttg cggcgcacgg tgatcgccag cacccgcgcc
3195001 cgacctttgg cgatgagccg ctcaacccgg cgggtgttct cgtacgtacg gatggtgccg
3195061 atcaccggca aggtgaggtg gcggcggtcg ggctccacac gcatcgcacc ggtcgtgaag
3195121 cacacgcgat cggcgtcgcg tcccttcttc ttaaaccggg gaacgcctac tgttttgcca
3195181 gcccgtttcc cggcacggca gctctgccag ttccaatacg catcgaccgc gcccgcgatg
3195241 ccatcggcat aggcctcttt cgagcattcc ggccaccaca cctgcccggt ctgcgcgttg
3195301 acacacacct ggtctttgac cgtgttccac cgtttgcgca acacccgcag cgacggcttc
3195361 gccgactcgg tgccatccgc gcgccacgcc ttgatgtcgg ctttaagcgc cgtgacggtc
3195421 cagttgaatg ccttacggcg agcaccaaaa tggcgcgcca agctggcagc ttgcgtctgg
3195481 gtcgggttca gcgtgaaccg aaacgcctgc acacaccacc cctcaggcac ctttaagcgc
3195541 gccatcacct agcctcgtgt cccccggcgc gtgccgccgc ggccacggca cgcgcagcac
3195601 ggttgccagc agcgcgtttg ccgtagagcc gcgcacatat cgacgtcaag atctcggtga
3195661 tatcgcccac aacgtcgtca tcgacatcgg ccgaatcgac cacaaccagc tcacggccgt
3195721 cagcggccag taccgcctgt acacactcaa agccgaaccg ccccaaccgg tcccgacgtt
3195781 tcatcacaat ccgcctcacc gtcggatcac ccagcagcgt aaggaacgtg cggcggcgcc
3195841 cgtacagcgc cgacccgact tcagtaacga ccttgccgac gggtatctgt tccgccgtgg
3195901 cccacgcggt cacgcctacc acttgccgat ccagatccac cttctgatca gccgacgaca
3195961 accgcgcaca caccgccgtc cgcccccacc gccccggctg cccggctggc tcgtcgacaa
3196021 gaatcactcg cccaaccctg cgggcgggaa ccggcaaccg cccgacacgc aaccagcgat
3196081 acgcaataac ccgcgccaca ccgttgccct cagcccacac caccagattc atacttccgt
3196141 tcctacaaca caccaccgac aaccaacgac cacccaaacg caacagctga cagccccttc
3196201 cgggcatcgg cagcaccggc cgaagactcc acagcgcgtt aatgcgccca ggtgtttgca
3196261 acggcggtgt cgaaggctgc cgagaacacg cccactgcgg caatgcgatg taggcttcac
3196321 gcccgtggct atggttcccg ctcaaacgac cggcggcact gcccacaagc gccgggagcg
3196381 cataggaacg atttaccgtt cggcccggca catgtgtcag tatccttgac atgggtctag
3196441 ccgatgacgc cccgctgggc tatctgctct accgggtggg agccgtactg cggccagagg
3196501 tttccgctgc gctcagtcca ctcggcctga cgctgcctga gttcgtctgc ctgagaatgc
3196561 tttcgcagtc accgggacta tccagcgccg aattggcccg gcacgcaagc gtcacaccgc
3196621 aggcgatgaa cacggtgttg cgcaagctgg aagatgccgg tgcggtggcc cggcccgcat
3196681 cggtgtcttc cgggcgttcg ctaccggcta cattgaccgc tcgaggccga gccctggcga
3196741 agcgcgccga ggccgtcgta cgcgccgccg atgcccgcgt cctggccagg ctgaccgcgc
3196801 ctcagcaacg cgagttcaaa cgaatgctgg agaagctcgg gtccgactag atccggacgc
3196861 gggctactcg gcgatatttg gggcgtggat ccgggcccag ggccgggcct cttcgagttc
3196921 gtaagccagc tccagcagca gcgcctcgcg cccggtatca gccgagagca tcatgcccac
3196981 gggcatgccg tccgcggatt gagccaacgg tagcgaaatc gccggcaccc ccgtgacgtt
3197041 ctgcactggc gtgaacacga cccagctgct cagccggtcg agcaccgtct gatagtcggt
3197101 aggcgcaagg tatccgacct gcggagtggc ctccgcgacc gttggcgtga gcaagacgtc
3197161 gtaggtaccg aagaaccgca cgctgcgccg ccgtagcatg cgcagacgca tgatcgccaa
3197221 cggcagccgg tgcaggttgc ggccggtatg gcgggccagc cccaaagtca gttcgtccag
3197281 ccgggtaggg tcgaacgtcc tgccgaatgt gcgccggccg ctgcgcactt gcgccagggc
3197341 caagaacccc caatagagca cgaaatcgtc cacgaaactg gccggtgccg gtgggtggtc
3197401 gacgtgttct acccggtgac ctagttcctc gagcagccct gccaacttca gcgtcagctg
3197461 ccgcacttcg gggctggcct cgcgcagaac cgagcgggtt actacggcaa tcctcagccg
3197521 ctgcttaacg gggcttgtga cgtccccgac cggcggcagc tggtggttac gccaaaggcg
3197581 ctcggcctcg cggtagaagg ctgcggtgtc gcgtaccgtg cgggtcagga cgccattggc
3197641 gacgatgccc accggcaacc tgcgatactc cggctccagc ggcaaccggc cgcgcgacgg
3197701 cttgagcccg accaacccgt tgcaggcggc cggaatacgg atcgagccgc cgccgtcgtt
3197761 ggcgtgcgcg atcggcacca cgccggctgc caccaaggcg cccgatcccg atgaggaggc
3197821 acccgctgtg tagtcggtat tccacggatt acggaccggt cccagccgag ggtgttcggc
3197881 cacggcgctg aagccgaatt ccgacaactg cgtcttgccc agggacacca gcccggtgcc
3197941 cagcaccacc cgggttatct cgctgtcggc gacggccgcg tatggttccc acgcgtcggt
3198001 gccatgcatc gacggctgtc cggcaacgtc gacgttgtcc ttgatgaagg tcggcactcc
3198061 actgaagaac gcttcctggc ccgtacccat cgcggccgcg tctcgcgcca cgtcgaaagc
3198121 cgcatacgcc aacgcgttca gtgccgggtt aacggcttcg gcgcgggcga tggcggcctc
3198181 gacgacgtct gcccgaccca ctcgacctga tcggatggcg tcggcgaggg cgaccgcgtc
3198241 gaggtcacca agggcatcgt caacgaaagc gtgtacgcgc gacatacccg gctaagcctg
3198301 gcccacctcg aagcggacga accgtgtcac cgtcacgccg gccacgtcga gcagggcctt
3198361 gacggtcttc ttattgtcgg acaccgacgc ctgctcaagc agcaccgcat ccttgaagaa
3198421 gccgttcagc cggccctcga caatcttggg cagcgcctgc tccggcttgc cctcggccct
3198481 tgccgtctcc tcggcgatgc ggcgttcgct ggccacgatg tcttcaggca cgtcgtcgcg
3198541 ggacaggtac cgcgcccgca gcgcggcgat ttgcaacgca acggcgtgcg cggcggccgc
3198601 gtcgtcgccg cggtactcga ccagtacacc caccgctggc ggcaggtcag cggaacgtcg
3198661 atgcaggtag gcttccacgg tcccgtcgaa aatcgccaca cgacgcagct cgagcttctc
3198721 gccgatcttg gccgacagct cggcgatcgc ctgctcgacg gtcttgtcgc cgatgctggc
3198781 acccttgagc gcgtcgacgt cggcgggctt agctgctgcc gccgccgcga ccacttggtc
3198841 ggccagcgtt tggaactccg cgttcttggc aacaaagtca gtctcgcagt tgagctcgat
3198901 cagcgcgccg tccttggccg ccaccaagcc ctcggccgta gcccgctcgg cacgcttgcc
3198961 gacatcctta gcgcccttga tccgcagcgc ctcgacggcc ttgtcgaagt ccccgtcggt
3199021 ttcggccagc gcgttcttac aggcgagcat gccggcgccg gtcagctccc tcagccgctt
3199081 gacgtcagcg gcagtgaagt tcgccatatc agcctttcct aggatgcatc tgtggttggt
3199141 tcggttgcgc ctgcgggggc gtcggtgagg gcagttgttg acgcggttgc tgatggcgtt
3199201 gccgaagctg tcgccgaggc cagcagctct tgctcccatt cggccagcgg ctcggcggct
3199261 tcggcctccg gcttgccgtc ggcgcgcccc agtccggcac gggcctgcag gccctcggcg
3199321 accgcggaag cgatcaccct agtcagcagc gcggccgagc ggatcgcgtc gtcgttgcct
3199381 gggattgggt agtcgacctc gtcggggtcg cagttcgtgt caaggatcgc gatgaccggg
3199441 atgcccagtt tgcgggcctc accgacggca atgtgctctt tgttcgtgtc gacgacccag
3199501 atcgccgacg gcaccttggc catgtcgcgg atgccgccga ggctgcgctc gagcttgttc
3199561 ttctcgcggg tcaatcccaa gatttccttc ttggtgcggc cctcgaagcc accggtctgc
3199621 tccatcgcct caagctcctt gaggcgttgc agccgcttat gcacggtgga gaagttggtg
3199681 agcatgcctc ccagccagcg ctggttcaca tacggcatgc cgacccgggt ggcttcggcg
3199741 gccaccgact cctgcgcctg cttctttgtg ccgacgaaga gcaccgaccc accgtgagcg
3199801 acggtctctt tcacgaactc gtacgcctta tcgatgaagg tcaacgtctg ctgcaggtcg
3199861 atgatgtaga tgccgttgcg gtcggtgaag atgaaacgct tcatcttggg attccagcga
3199921 cgggtctgat gcccgaagtg ggtgccgctg tcaagcagct gcttcatggt gactacggcc
3199981 atacctatgc cttactcatg tgtcggttgt tcgcccggca tcggctgaag ccgggccctg
3200041 gcgtctgccg cgatgccgga cccgggagga aatccccgaa gggaaccgcc gcgggaccgc
3200101 cccggcatgc tgttgcggat cccggaaagg cgggccgcgg tgcagacacg cgaagtcagc
3200161 ccgccgatgc gagctgcgcc gagtagttta caccgaccca gctggtgatt ttcccggcag
3200221 cggaatccac agcgacgaca ttgtccacaa aacgggcggc ggcgattggc caaatcgccc
3200281 gcgcggcgct gcactgcaaa ggtacggagg gttctgagcc gcagcgtact gatcctttgc
3200341 tggtcgctgc ttggtgcggc gccggcccat gccgacgact cccggctggg ctggccgctg
3200401 cggccgccgc cggcggtagt ccggcagttc gacgccgcat cgcccaattg gaatccgggg
3200461 caccgcggtg tcgacctggc cgggcgcccc ggtcagccgg tttacgcggc cggcagcgcg
3200521 acggtcgtat tcgccgggct gctcgcggga cggccggtgg tttcactggc ccacccgggt
3200581 gggctacgca ccagctacga gccggtagtc gcccaggtcc gggtcggtca gccggtgtcg
3200641 gcgcccaccg tgatcggcgc gctggcggcc gggcaccccg ggtgccaggc cgccgcctgt
3200701 ctgcactggg gggcgatgtg gggcccggct tcgggcgcca actatgtcga tccgctgggc
3200761 ctgctgaagt ccacaccgat acggctcaag ccgctatcca gcgaagggcg gacgctgcat
3200821 taccgccaag cggaacccgt atttgtgaac gaagccgccg ccggtgctct ggccggcgct
3200881 ggccatcgga aatccccgaa gcagggcgtt ttccgcggtg ccgcgcaggg cggtgacatc
3200941 gtcgcccggc aaccgccagg ccgctgggtt tgcccatcga gcgcgggcgg cccaatcggg
3201001 tggcaccgac aatgaaccag ccgagctccc cttccccaaa gcggccgata ccgatccgcc
3201061 aatgctttct cggtctagtg cccagtacca gtacggctgg ggcgtctgaa ccccgccaac
3201121 agcaccgccg cctgccacac ttgggctcgc ccgcgggccg gcgaagatgg ttggacccca
3201181 gctgtcaagc accgaggatc ccgagtcacc ggcgccgccc ggggtgcccg ggatcgcttg
3201241 ctgggcgagc gaagcctcga attgcagtag cccttcgtcg aagtagctga tgcccagcaa
3201301 ccgaacgatc gtcatcctgt tgtcaggcgt gagaccgaga agattctccg cgagccattg
3201361 ctgcaatgcc gagtaccacg ggatcagtga cgtcgacgag agttgctgca acagttgggg
3201421 caccgcggcg gtggtggcca gcggtgggac cgtcgacgat accgtcgccg ccgcctggcc
3201481 ggccagcgcg gcagggctgg tagtcactgg cgccgcggtg aacggggtca actccgtggc
3201541 gattgccgcg gagcccgcat aggcgtacat ggcggcagcg tcttgggccc acatctcggc
3201601 gtattgggcc tcggtggccg cgatcgccgg ggtgttctgc ccgaaaaagt tggtcgcgac
3201661 cagcgccacc aacagcgcgc ggttggcaac gaccaccggc gggggcaccg tcatcgcaaa
3201721 cgccagctca taggctgccg cggccgctct ggcctgcatg cccgcctgtt cagcctgacc
3201781 ggcggtggcg ctgagccacg ccacataagg cgtgaccgcg gccaccatcg acgccgctgc
3201841 gggccccgcc cagtacgcac cggtcagctc cgagatagcc aaccggtagc cgccggcggc
3201901 caagcccaat tcagccgcca aactatccca ggccgccgcg gcggccatca tgggccccga
3201961 tcccggacct gcgtacattc gaccggagtt gatctcgggc ggcaacaccc caaagtccaa
3202021 cgcccatccc tccctagccg gccgggatca cggcgtggtt acgcgcccca cccgaatagg
3202081 cagtggtacg tgatgcggtc acgaactggt cttgaatcgc cagcctcagg tcgctgatcg
3202141 ctgacagcgg ccccggtcgt cgaacaagcc agtccatcct gtgccctcat ccctgatagc
3202201 tggattttgg cggcttgaca tcggccgcac cagcgtttct gggtaagtgc ttacaaacga
3202261 gacgcatttg ctgtgaccgg agccgaatgt ttgattcccg gccagctacc gttcacctga
3202321 aggaagtcgg cgcgttaccc acagctcgat attcggggtc ctgccggccc gaaccgccac
3202381 cgcacaatcg atgccggctt cgcggctacc gtcgactcca tgaccgttgc cagcaccgct
3202441 caccatacac gtcggctacg tttcgggttg gcggcaccgt tgccccgcgc gggcacccag
3202501 atgcgcgcct tcgcgcaggc tgtcgaggcc gccgggttcg acgtgctggc cttcccggac
3202561 cacctggtgc cttcggtttc gccgttcgca ggcgcgaccg ccgcggcgat ggccacgcaa
3202621 cgactgcaca ccggcacatt ggtgctcaac aacgactttc gccatcccgt ggacaccgct
3202681 cgagaggcgg ccggtgtggc aaccctcgcc gaaggccgct tcgaactggg actgggcgcc
3202741 ggacaccgga ggtccgaata cgacgccgcc ggcattacct tcgattccgg ggcaacacgg
3202801 gtggcgcggc tcatcgaatc ggcgcacctg atccgtgcgc tgctggacgc ggagcccgtc
3202861 gacttcgacg ggcagcatta ccgggtgcac gccgaagcgg gctcactggt ggcaccgccg
3202921 aaggtccggg tccccctgct agtgggcggc aacgggaccg aggtgctgcg gctgggcgga
3202981 cgcatcgccg acattgtcgg cctggccggg atcagccaca accgcgacgc cacccaggtc
3203041 cggttcaccc acttcgacgc cgacggcctg gccgaccgga tcgccgtggt acgtcacgcg
3203101 gccggcgatc gcttcgaagc cattgagctc aacgcgctga tccaggcggt ggtctgcacc
3203161 aacgaccgaa acgcggcggc cgccgaactg gccgccacct tgggcgggat cacgcccgag
3203221 caggtcctcg agtcgccgtt tctgctgctc ggtacccacg agcagatggc cgaggctctc
3203281 gccgcgcggc agcggcggtt cggtgtcagc tattggacgg tgttcgacga gtgggctggc
3203341 cgcgcgtcgg caatgcgcga catcgccgag gtcatcgcgc tcctgcgcta cggctaggcc
3203401 cgcggatggg cccgctcgtg caccgcccgc aaccgggcga ccgcgacgtg ggtgtacagc
3203461 tgcgtggtcg ccaggctgga atgaccgagc agctcctgga ccacccgcag gtcggcgcca
3203521 ccttccagca ggtgggtcgc cgcgctgtgc cgcagcccgt gcggccccat atcgggtgcg
3203581 ccgtccaccg cggccacggt ctggtgcacc gcagtgcgtg cttgccgcac gtcaaggcgc
3203641 cggccccggg cacccagcag cagcgcgtgc ccggactccg cggtgaccag cgcgcgacgg
3203701 ccgtcgacca gccaggcgtg cagcgcatcg gcggctggct gcccgaacgg gacggtgcgc
3203761 tgcttgttgc ccttgccgag cacccgaacc aaccgatggc cggtgtcgat gtcgtcgacg
3203821 tccaggccgc acagctcgct gacccggata ccggtggcgt acaacagctc gacgatcaac
3203881 cggtcccgca gcgctagcgg atcaccttgc tctgcaccag attcggcagc cgccatggcg
3203941 cgcagcgcct gatcctgacg cagcaccgcc ggcaaggtgc gacgggcctt cggcacctgt
3204001 agccgggccg caggatcacc ggccagtagc ccgcgccgca ccgcccaggc ggtgaatgcc
3204061 ttaaccgccg aagtgcgccg cgccagcgtc gtgcgggcgg cgcccgctcc cgccgtcgcg
3204121 gccagccaag accgcaggac cgaaagggtt agtgcgtcca gactcgatcc gcgatcggcg
3204181 agaaacgcga agagcgatct tagatcgccc aggtaggcac gacgggtgtg caccgaccga
3204241 ccgcattgca gggcaaggta ttcgtcgaac tcgtcaagga tcgcctgcac tcccccacag
3204301 tcgcaggcat gacgtctcga gcccgagtcg acgcgccgca ccgtgtccgg ggtgagatct
3204361 ttcggcctgg gatagccgac ctagtgagtc ccggcctccg cctcagccag ttctttcttc
3204421 catttgcgga acatctcctc ggtgcgtccg cgccgccagt aaccggagat cgacgacgcc
3204481 catttggcat ccacaccgcg ctcgttgcga acgtatggcc gcaagttatg catgacggct
3204541 tgcgcctcac cgtgaataaa gacgtggacc tgtcccggca gccacgcggt ggtggtgacc
3204601 gcctcgatca gcggcgcgtg atcaccggcg cggtcctcgg gaaccagatc ggcgcgcccg
3204661 ccgcgataga cccagttcac ctcgacggca tccggcgcgg tcaggccgat ctcgtcgtcc
3204721 gggccggcaa cttcgatgaa tgccctaccg attgcgtcgg ggggcaacgc ttccagcgcg
3204781 gcggcgatgg cggggatcgc cgattcgtca cccgccagca aatgccagtc ggcggctggg
3204841 tcgggggcgt acgcgccgcc ggggcccatc aggtagatcg gttgcccacg ctgggcccca
3204901 gccgcccacg gaccggctac cccgtgctca ccgtgcagca cgatgtccac ggcgatctcg
3204961 cgggccgcgg cgtcgacatg acgaacggtc atggtgcgca ccggcggccg cttcgcggtg
3205021 ggcaggtcgg cgaagctgtc cagggtcagc ggccggggca accgcccgac atcgacatcg
3205081 tcgtcgacga acaccagctt gatgtaagag tcggtgaagt cgctggggac gaatgtgtcg
3205141 aagccgctgc cgccgagcac tacccggacc atgtgcggcg cgaggtgtcg ggtagcgaca
3205201 acctcaaagg cgtgcaatgg tcgacccgcc acatgtcctc ctgtccagac ccgacccgcg
3205261 tcgactatac gagccgggcc gctgcaccct tggccgcggc ctgaccggca ccggcgcgca
3205321 atattcgcca ccgcccgtcg cgacactcgg ccaacccggc gacctcgagg attgccagcg
3205381 gacctagcac ctgcgcgggc agcagcccgg agccgacagc gatctcatca atggtagcgg
3205441 cgccgcggcc cggcagggcc tcgtacactt ggcgttcggc ttcgcttagc acgtcgagcg
3205501 ctgcgccggg ccgcggttca tcaccggcca actcaccgat gtgaccgacg aactcgacga
3205561 tatcgtcggc ccgggtgacc aactccgcgc catggcgaag cagcgtatga cagcccgccg
3205621 atgccgagga tgtcaccggg ccgggcaccg ctgccaccac ccggcccaat gcccgcgccc
3205681 aggcagcggt gttggcggcg ccgctgcgca ggcccgcttc caccactacc gccgccctcg
3205741 cgaccgcggc caccaaccgg ttgcgggtta ggaaccggtg ccgggccgga cggacaccgg
3205801 gcgggtattc ggtgaacagc accccatgtt gggcaatgcg atgtagcaac gccgaatggc
3205861 ccgccggata cgggatgtca aatccgccgg ccagtacggc cacggtgatg ccctcggaat
3205921 ccagcgccgc gcggtgagcc gcaccgtcga tcccgtaggc gccaccggag acgaccgcga
3205981 cgtcgcgctc tgccaacccg gcggccagat cggccgcgac atgctcgccg taggccgtcg
3206041 cagcccgggt tccaacgacg gcggccgcac gtggtgccac ttcgtccagg cgcgcggggc
3206101 ccagggccca caacaccagc ggcgagtggc cgcacggcct tgcccgggct ccggcgccac
3206161 tgaaagcggc gaacgccagc accggccact cgtcgtcgtc gggagtgatc agacgcccac
3206221 cgcggcgcat gagtagctcg agatcgtctg cggcccggtc tatttcgcgt cgggcaccgg
3206281 tgtgctgcgc cagctcgtta ccgacctgcc cgcggcgcac ccggtcggcg gcctccacgg
3206341 ggcccacaca tcgcaccagc gcggccagct gggcgcacgg cggttcggcc acccgggaca
3206401 gataggccca cgcccgcgcc gtcggatcga tcatcgtcgt gctccggttt gccggaagct
3206461 cagggcggcg gcgacctcgt cgatgcctgg cgatgtgcga ccggccaagt cggccaaact
3206521 ccaggccacc cgcaaggtgc gatccacacc gcggatgctg agtagcccgc ggtccagcgc
3206581 ggtgcgcaac gggagcatcg cggcgctgct gggccgaaac ttgcggcgca acagcggccc
3206641 gctgacttcg gcgttggtcc ggaacccatg tggccgccat cgttgcgcgg ccgcctcccg
3206701 ggccagcgcc acccgctggc gaacctgcga cgtcgactcg ccgtccgcgg ccgagaacgc
3206761 cccggcccga agccgatgca tctgcacccg taggtccacc cgatccagca acggcccaga
3206821 cagtttgccc agataccgtc gtttggtagc cgccgcacag atgcaatcct gtggatcggc
3206881 gggcgcgcac gggcacgggt tggcggctag cacgagctga aaccgtgccg ggtagcacgc
3206941 caccccgtca cggcgcgcta ggcggatttc accgtcctcc aacggtgttc gcaatgcttc
3207001 cagcgcgcta aggctgatct cggcgcactc gtccaggaac aacaccccgc gatgcgccct
3207061 gctgaccgcc cctgggcgag ccatccccga tcccccgccg acaagcgccg caacgctgga
3207121 actgtggtgc ggcgccacga acggcggccg ggtaatcaac ggtgtgtccc ccgacagcag
3207181 gccagccacc gagtggatcg cggtcacctc caacgactcg ctgcccgaca gcgacggcaa
3207241 cagccccgga agacgttgcg ccagcattgt tttgccgaca cccggtggac cagtcagcat
3207301 gaggtgatgc gccccggcgg cggccacctc gacggcgaac cgtgcttggg actggcccac
3207361 cacatcggcg aggtccgccg cagactcggg ggtggtgtcg gccgtggtga tccgcccggc
3207421 caagccggtg gacccgcgta gccagctctg caactgcccc agcgtgcgaa caccccggac
3207481 gtcgattccg tccaccaggc tggcctcggg caggttgtcg gccggaacga cgacggccgg
3207541 ccaaccgtca cgtttggctg ccagcacggc gggcaacacc ccacgcaccg gacgcacccg
3207601 tccgtccagc gacaattcac ccagcagcag cgtgttctcc agacgttccc acggcttctt
3207661 ttgttgcgcc gacaacaccg ccgcggccag ggcgatgtcg tagaccgagc ccattttcgg
3207721 cagcgtcgcc ggcgacagcg cgagcgtgag cctggccatc ggccagctgt ttccgcaatt
3207781 ggtgaccgcc gcgcggaccc ggtcgcggga ctcctgcaat gcagcatcgg gcagacccac
3207841 cagatgcaca cccggcaacc ctgaggtgat gtcggcttcg atttccacga tctcgccgtc
3207901 cagcccccgc accgcgaccg agaacgcacg ccccagcgcc atcagccgat cccctgcagg
3207961 tgggtgagct ctggggtgcg gcctgaattc ttggggccga ctcgcacgcc gatcacatcg
3208021 atgcgcaccg cagcccagcg ctcttcctgg tcggccagcc acagcccggc caggcgacgc
3208081 aggcggcgaa ccttgcgctc ggtcaccgcg tgcgcgagcc ccccataacc gtcgccggtg
3208141 cgggtcttga cctcgacgaa caccaccgtg cgggtggcag cgtcgcaggc gatcacgtcc
3208201 agctcgccgt agcggcaacg ccagttgcgg ttcaagatcc gcaaccccat gctggtcagg
3208261 tagtccaccg ctagggcctc gcccatcgct cccagctgaa cccgagtcat cgtcttcagg
3208321 gttgtcatgc ggccaacctg cacgctggcc ccgacatcac ctgccacgaa tcgcgtctca
3208381 ccgatgccgc gacgaccagt tatccccagt cgcggccctg tccacagccc cagtactgcg
3208441 cgggatcacg acaccgcgtc cttgtcatca tcgtctccgt cacatagcaa cttctcgggt
3208501 cccggctact cgcaacgcac cgcaggcggc acacgccgat ccagcaacat catgttcggc
3208561 gccggaagag tcccgttagg tgattcggtc cgctctggtg tagacgttca tcgagtcccc
3208621 ccgcaggaaa gccaccagcg tgatcccgga cgcgtcggcc aacgaaaccg ccagcgacga
3208681 cggcgcggat accgcggcca gcaccggaat cccagccatc agcgcctttt gggtcaactc
3208741 gaacgacgcc cgcccgctga ccaacaacac cgaggcgcca agcggtattc ggtcacgctc
3208801 gaaagcccag ccgatgacct tgtcgaccgc attgtgccgg ccgatatcct cacgcacggc
3208861 aagcatggcg ccgtccaccc cgaatagtgc cgcagcgtgc agcccaccgg ttctcgcgaa
3208921 aaccttttgc gcgcgccgaa gttggtccgg catcgccttg agagtgtcgg cggcgacggt
3208981 agcgggatcg ccgcccggtg cgaatcggct gacctggctc accgcctgaa gcgacgcctt
3209041 accacagact ccgcacgacg aggtggtgta gaaggtgcgg gtgacatcga catcgggcgg
3209101 cttgacgccg ggcgccagag ccacatccaa aacgttgtac gtgctggccc ctgtggcatt
3209161 gccctcgacg cgcctgccac agtagctaac ggtcagcacg tcttcgcggt gcgcaaccac
3209221 cccttcggca agcagaaagc cttgcaccag ttcgaaatcc gatcctggcg tgcgcatggt
3209281 cacggtaacc ggcgtcccat tgacgcggat ctccagcggc tcctcgacgg ccaaggtttc
3209341 cggccgggtg atcacctgat cggcgctgag atgcctgacc cgccgatgcg ccgttgcgta
3209401 ccccactagg ccgttggctc caatcgcacg atgatcgcct tcgacaccgg ggtgttcgat
3209461 tgggccgcgg tatggtcgag cggaaccagc ggattggtct ccgggtagta ggccgcagca
3209521 ttgccgaccg gcgtcgaata tgccaccacc agaaagtctt ttgcccgccg ttcttgcaga
3209581 ccgccttggc cgtcggtcca ctccgacacc aggtcgacac ggtcacccgc cgtcaaaccg
3209641 aacgtttcga tgtcggccgg gttgatgaac accacccggc gtccgccctt cacgccgcga
3209701 tatcggtcgt cgagcccgta gatcgtggtg ttgtactggt catggctgcg tagggtctgt
3209761 agcaccagcc ggccgggcgg caccggcacc cactgcaacg gattgaccgc gaagttagct
3209821 ttgcctgtgc tggtacggaa ttcgcgcgca tcgcgcggcg ggtgcggcaa ttggaatccg
3209881 tcgggcacac gcaccttgtg gttgtagtcg tcacagccgg gcaccaccgc ggcgatggcg
3209941 tcacggatgg tgtcgtagtc atctgcgaac cgttcccatg gcaccggatg tccggggccg
3210001 aacaaggcgc gggccagctg gcagatgatc tgcacctcgc tgcgcacctg atcgctgggc
3210061 gggtgcaggc taccacgcga cagatgcacc atcgacatcg aatcctcaac cgacaccaat
3210121 tgtttgcgac cattgcgggt atcgcgatcg gtccgaccca gcgtcggcag gatcagcgcg
3210181 gtggcgccgt ggacaaggtg gctgcggttg agcttggtcg agacttgcac agtcagcgcg
3210241 cacctgcgca aggccgcctc ggtgacggcg gtgtcggggg tggccgacgc gaagtttccg
3210301 cccatgccca tgaagacgct gacccgaccg tcgcgcatgg cccggattgc ggccacggtg
3210361 tcaaagccgt gcgctcgggg gctggtaatg ccgaactcac gatccagcgc cgccaggaac
3210421 tgctcgggca tcttctccca gatccccatc gtgcggtccc cttgtacgtt ggaatgcccg
3210481 cgcaccgggc acacccccgc gccgggtttg ccgatcatgc cccgcagcag cagcacgttg
3210541 gtgacctcac cgatggtggc cacggcgtgg gcgtgttggg tcaagcccat agcccagcag
3210601 atgaccgtgc gctgcgacgc catcaacatc gcggcgaccc gctgaagttg cgcgagttcg
3210661 atgccggtgg cgtccatcac ggtgtccaag ccgacctgca gagtccggcg gcggtacccg
3210721 tcgaatccgg cacaatggtt gtcgacgaac gaccggtcga caacgctgcc ggggaccctc
3210781 tcctcggcct ccaacaacaa cctgcctaac ccggcgaaca atgccatgtc cccgccgagg
3210841 cggatctgca cgaactcgtc ggcgatcggg ataccatgtc ccacaacccc gttcaccttc
3210901 tgcggatctt tgaaccgaat caacccggcc tcgggcagcg ggttcacggc gatgatcttg
3210961 gcgccgttgg ccttcgcttt ccccagcacc gacagcatgc ggggatgatt ggtaccgggg
3211021 ttttgtccgg cgatcacgat caggtcggcg tgctcgacgt caccgatggt caccgagcct
3211081 tttccgattc cgatcgagtc ggtcagcgcc gcacccgagg actcgtggca catgttggag
3211141 cagtcgggca ggttgttggt gccgaaagag cgcacgagca gctggtaaca gaacgccgct
3211201 tcgttgctgg tgcgccccga tgtgtagaac acggcccggt cgggactgtc caacccgttg
3211261 agctgctcgg cgatcagctg ataagcggca tcccagctga tgggccggta gtggtcatca
3211321 ccggggcgca agaccatcgg gtgggcgagc cggccttgct gggacagcca atattcgggc
3211381 ttcgcggaca gctccgccac cgagtgccga gcgaagaact ccgcagtgac ggtacgcttg
3211441 gtggcctctt cggcgactgc cttggcgccg ttctcgcaga actcggccag cttgcgtccg
3211501 ccgggctcct ccggccacgc gcagcctggg cagtcgaagc cgttacgctg attcaaccga
3211561 gccagcgccg ccgcggtgcg cagcgcgccc atctgctgca tcccccgctg cagcgatacc
3211621 atcaccgccc gcacgcccgc ggcctcgcgt ttgcgcggcg ccaccgttac cgcctgctcg
3211681 tcatagtcgg cgaggacgtc gcgagacgcc gccgaccgct gccacctcac cgcctcaacg
3211741 tacatccacg accgaccgac tgccgcacac agccgattga cgtgtgacgg cgcttggggc
3211801 agctattccg gcaggcgcag ctcgggtttt tcgacttcct cgatgttgac gtccttgaac
3211861 gtgaccaccc gcacctgttt gacgaaccgt gccggccggt acatgtccca cacccaggcg
3211921 tcagccagcc gcagctcgaa gtacacctca ccgtcggtat tccgcggcac catctccaca
3211981 ctgtttgcca aatagaaacg tcgctcggtt tctacgacgt agctgaactg gccgacgatg
3212041 tccttgtatt cgcgatacag cgagagctcc atctcggttt catacttttc gagatcctct
3212101 gcactcatct gctcagacgt ccttctccct gccggttccc cggcttcccc gctcagtgcc
3212161 cctaagtgcc ctgagcgcga cccgtggccc gcattgtcgc tgggtgggaa ctcttgctcc
3212221 atcttccctc acccgtctgt gccgtcccgt cccgagggtc gggttggccg tcggcgacct
3212281 ctgcggtgtt cgacccactc gccacccggc gaacattgat gaacgagtaa cggtgctgcg
3212341 ggcagggtcc caatcgggcc agcgcccggc tgtgcgccgg ggtgctgtaa cccttgtgct
3212401 ccgcgaaacc gtacccgggg tgatcggcgt ccaacgcaac catcacgcgg tcccggctga
3212461 ccttggcgag cacgctagcc gcggcgatgc aggcggctgc cgcgtcgcca ccgatcaccg
3212521 gcaacgacgg catcggcagt cctggcacgc gaaagccgtc gctgagcaca taaccgggcc
3212581 gcaccgccag accggccacc gcgcgccgca taccttcgat attggccacg tgcacgccgc
3212641 ggcggtcgac ctcggccgac gggatgaaca ccacgtgata ggccaccgca taccggcaga
3212701 tcagcgggaa cagcttctcc cgcgcttgct cgctgagctt cttcgaatca tcaagggcgg
3212761 caagacttgc tatccgcccg gggccaagca cgcaggccgc gaccaccaac gggccagcgc
3212821 aggcgccgcg acccacttcg tcgaccccgg ccaccggccc cagaccacca cgatgcagcg
3212881 cggactccag ggtgcgcatt ccccgcaaac ccccagattt acggatcacc gtccgcggtg
3212941 gccaggtctt ggtcatattc cagccatggc taccgacctt gctggggatt caccgaacgc
3213001 acaacacccc aacgcgacgg cggccacacg atcaacctgg ccttaccgat gacgttggcc
3213061 accggcacgg tccccggtag cggatcgtca gtacatagca acgggcagtg agcgcgggaa
3213121 tccgccgaat gggtgcggtt gtcgcccatc acccagacac gcccgggcgg gacggtgacc
3213181 ggcccgaact cgctgcccag gcacgggtat atcgacgggt cggccatcat ggtggccgga
3213241 tccaggtatg gctccttcag tggcctgccg ttgaccgtca ggccggtgtc ggaccggcat
3213301 tgaaccgtct gtccgccgac cgcgatgaca cgcttgacca ggtcgttctc gtcgggaggc
3213361 acgaaaccga tgaacgacaa cgcgttctgc acccagcgca cggcgacgtt gtgcgaacgg
3213421 atcgacttgt aaccaacgtt ccacgacggc ggtcccctga agacgatgac gtcgccaggt
3213481 tgcggtgagc cgaagcggta gctgagtttg tccaccatga tgcggtcgcc gacgcacgtc
3213541 gaacacccgt gcaacgtggg ttccatcgat tccgacggaa tcagataagg gcgcgcgaca
3213601 aacgtcagca tgacgtagta gagcaccaca gcaatcaccg ccagcaccgc gaactcccgc
3213661 agcgttgatc gcttcgcggg ccgcggctcg tccgttttgg ccgccttgga gtcgccttcg
3213721 gagtccgcat ccggggctgc gtcgaacggg gctgcgtcga agacctggcc ggcaatgtcc
3213781 gggtcccggg aggagagctc cggctctgcc ggacccggct ggcgctccga tggggagtcc
3213841 gtggtttcgg tcacgagatc agcgtagcca gcgcaggtgg cggctttcga acatcgccga
3213901 gacgttcccg gtcagcgctt ctccttgatc ttggccttct ttccgcgcag ttcgcgcagg
3213961 tagtacagct tggcgcggcg aacatcgcca cgggtcacca cctcgatatg gtcgatgttc
3214021 ggcgagtgca cggggaaggt ccgttcgacg ccgacgccgt agctctcctt gcgcaccgtg
3214081 aacgtctcgc ggatgccccc gccctgccgg cggatcacca cgcccttgaa cacctggaga
3214141 cgttccttgg cgccctcgat caccttgaca tgcacgttga tggtgtcgcc cgggttgaac
3214201 gccgggatgt cgtcgcgcaa cgacggcttg tcgacgaagt ccagccggtt cattggaaat
3214261 gaccatcctt ggggtcgcgg cgtggttacc ccccacacgc agcgtgcggt ggtcaccaag
3214321 ccggtgggtt cgggcttatt ggtgcatctc gcagcaggcg gcacgcaacc cggccgacca
3214381 ccgcgacaga caactgctca attgtgccag acggtacgca tgcagtgaaa tcacaggaaa
3214441 tctccggtgg ttcgcggccg tcgaaaagcg cccgcaaatg gtacacatga cttacatatg
3214501 actagggtca aaccgcgcgt gtggaaaccc gaagcttggc gtgacaccca acagagggca
3214561 cttaagaggg caatgcggcc gcctacctgc acgttttcgc gatgtcagag gatgccgagg
3214621 gagaacaatg cgagcacggc cgctgacgtt gctcaccgct ttggcggcgg tgacattggt
3214681 ggtggttgcg ggctgcgagg cccgagtcga ggccgaagca tatagcgcgg ccgaccgcat
3214741 ttcgtctcga ccgcaagcgc gacctcagcc gcagccggtg gagctactgc tgcgcgccat
3214801 cacgccgcct agggctccgg cggcgtcgcc gaacgtcggg tttggcgaac tgcctacccg
3214861 ggtccggcag gcaaccgatg aggccgccgc catgggcgcc accctctcgg tggcggtgct
3214921 cgatcgcgct actggccagc tggtctccaa cggcaacacg cagattatcg ctaccgcgtc
3214981 ggtggccaag ctgttcatcg ccgacgatct gctgctggcc gaggccgagg gcaaagtcac
3215041 attgtcccca gaggaccatc atgcgttgga cgtcatgctg cagtcatccg acgatggtgc
3215101 ggccgagcga ttctggagtc aggacggcgg caatgccgtc gtcactcaag tcgcgcgccg
3215161 atatgggctc aggtcgaccg cgcctcccag cgacgggcgc tggtggaaca caatcagctc
3215221 cgcgccagac ctgatccgct actacgacat gctgctcgac gggtccggcg gcctaccact
3215281 ggatcgggcc gccgtcatca tcgccgacct ggcccagtcc acaccgaccg ggatcgacgg
3215341 ctacccgcag cggttcggca tccccgacgg tttgtacgcc gaaccggtcg cagtcaaaca
3215401 gggctggatg tgctgtatcg gcagcagctg gatgcatctg tccaccgggg tgatcggccc
3215461 ggaacgccgc tacatcatgg tgatcgagtc actgcagccc gccgacgacg ccaccgctcg
3215521 agcaaccatc acgcaagccg tcagaacgat gtttcccaac ggccggatct gacgctcgtc
3215581 cggtcgcctc accggcgcga gcagacgcaa aagccaccgc acgttcggcg tgtcggggga
3215641 tttcgcgtct gctcgccagc ggggctagtc ggggtgggac aggtcggggc gtcgttcgcg
3215701 ggtgcgctgc agcgagacct ctctgcgcca ggcggcaatt cgggcatggt cgccggagag
3215761 taggacctcg ggtacatcga ggccacgcca gctcgccggc cgggtgtagc tcggaccctc
3215821 aaggagcccg tccaggcccg ttgagtgcga atcatcttgg tgggaagcgg gattgccgag
3215881 aacaccggcc aacagtcgca gcacggcttc gaccatcacc acggccgccg actccccgcc
3215941 gggcaatacg tagtcgccga tcgagacttc ttcgacgcgc attcgccggg cggcatcctg
3216001 cacgacccgc tggtcgatgc cttcgtagcg gccgcaggcg aacaccagat ggctctcggt
3216061 ggtccagcgc tgggcggtgg cctgggtaaa caacacaccg gcgggcgtgg gaacaatcaa
3216121 caacgtttcg ctggaacaaa tttcgtcaag cgcttcaccc cacaccggcg ccttcatcac
3216181 cattcccggg ccgccgccgt agggtgcgtc gtccaccgag tgatgcacat cgtgggtcca
3216241 gcgccgcagg tcgtgcacgt taaggtcgac caggcccgat tcgatcgcct tgcccggcaa
3216301 cgactgtcgc aacgggtcca ggcaggcggg gaagatcgtc acgatatcga tgcgcacgcc
3216361 ttactccaga ttcagcaagc catggggcgg atcaatctca acgatgccgt cgtccaatga
3216421 caccgacgtg acgatggcac gcacaaacgg caccaaaacc tcatcggaat cacgcttgac
3216481 cgccagcaac tcaccagcgg cggtgtgcac cacttcggtg acgacaccaa caccctcccc
3216541 cgtcgccgtc tggaccataa gccccaccag ctggtgatcg taataggtgt ccggctcgtc
3216601 gatcgggggc aagtcatcgg cgtcgatcac gaacaagctg ccgcgcaacg catcggctgc
3216661 gtctcgatcg gccactccag cgagtcgcac caacaggcgg ccgccgtgct gccgcacact
3216721 ttcgatgacg taactcaccg cactgccctc ggcaccaccg tcaaaaggcc ccttagcgcg
3216781 caacctggta cccggcgcaa accggtcagc tgggtcgtcg gtgcggatct cgacgacgac
3216841 ctcgccggtg acaccgtgcg acttcaccac ccgcccgact accagctcca tgagcggggc
3216901 tccgctactg gtcggtgtcc accacgtcga cgcggatacc gcggccaccg ataccggcta
3216961 ccagagtgcg caatgcggta gcggtgcgtc ccccacgacc gatcaccttg cccaggtcgt
3217021 ctggatgaac gtggacttcg acggtgcgcc cccgccgact ggttatcagg tctacccgga
3217081 catcgtcagg attgtcgacg atcccacgga ccagatgctc aacagcgtca acgacgacgg
3217141 cgctcatttc cccgtcagct ttccgccgtc agctcggcct gctcgccacc cagcgccggc
3217201 gtgtccggct gctcaggctg cggcgctggc tcagcagcct tggcagcctt tttggccggc
3217261 gacttcttct tcggtttggt ggcctcggtg gtaggaccac cgtcggcggc ggccaacgcg
3217321 gcgttgaaca cctcgagctt gctgggcttg ggtgcggcga ccttcaaccg gccctgagcg
3217381 ccaggtaggc ccttaaactt ctgccaatcc ccggtgatct tcagcagctt gaggacgggc
3217441 tcggtgggct gagcacccac cgagagccag tactgggcac gctcggagtt gatctcgatg
3217501 agactcggct cttctttggg gtggtaccgg ccgattacct cgatcgctcg gccgtcgcgg
3217561 cgggtgcgcg catcggcgac ggcgacgcgg tactgaggat tgcggatctt gccaagccga
3217621 gtgagcttga tcttcacagc catgattgag cgctcctatt ggtgtcacgc tgcaattcag
3217681 cgacccgggc gggatgcccg gatccggttt tgcctcgcgt gtatgaccac cgggcggcaa
3217741 ccccgaacag gacaagtcgt cgcgcggtgg acagccgcca attgtgccag aacgtgatgc
3217801 tggggcagta attcgcccag cgggcttcac atcattttct ggaagcactt ggtttcgacc
3217861 cgcctgatga tccgccagcc atcgggggtg cgcacgaaat cgtcgtcgta ccacagtcca
3217921 cagaacagca cttgctgccg gtcgccggcg aacaccatcg ggttgaagca gatcacccgc
3217981 gacgacgcgg tatcgccgtc gacacggacc gagaagttgc ccaacatgtg cgcatatacc
3218041 gggaagtttc ccagcacctg cgacagccat tgcttgatct tcggatacct gccgtcgatg
3218101 ccacctagcg cgcgatagtc gatataggcg tcgggggtga acacccggtc aagatcgtcg
3218161 aatcggcgct ggtcaatcgc gctggagtag tccaccagca actgctggat ttccaaccgg
3218221 tcggaaattt cggccacgct caacatgctc cgatccaaca ccgcacacat cggccggaca
3218281 gcccccgacc agcccgagaa taggcctacc ggagccctgg aagttaaact ctgcgcccat
3218341 gcgaaagctc atgaccgcga ccgccgcgct ctgtgcctgc gcagtcaccg tcagtgcggg
3218401 tgccgcgtgg gccgatgccg acgtgcagcc ggccggctcc gtgccgatcc ccgatggccc
3218461 ggctcagacc tggatcgtgg ccgacctcga tagcggtcag gtgctagccg gccgcgacca
3218521 aaacgtggcc catccgcccg cgagcaccat caaggtgctg ttggcgctgg tggcactcga
3218581 cgagctggac ctgaactcca cggtcgtcgc cgacgtcgcc gacacacagg ccgagtgcaa
3218641 ctgcgtcggc gtcaaaccgg ggcgcagcta caccgcgcgc cagctgctcg acggcctgtt
3218701 gctggtgtcg ggcaacgacg ccgccaacac gttggcgcac atgctgggtg gccaagacgt
3218761 caccgtggcc aagatgaacg ccaaagccgc caccctaggt gcgacgtcca cccacgcgac
3218821 gacgccgtcc ggcctagacg gacccggcgg ctccggggcg tccaccgcgc acgacctggt
3218881 ggtcatcttc cgggccgcga tggccaatcc ggtgttcgcg cagatcaccg ccgagccctc
3218941 ggcgatgttc cccagcgata acggcgaaca gctgatcgtc aaccaggacg agctgctgca
3219001 gcggtacccg ggcgcgatcg gcggcaagac gggctacacc aacgccgctc gcaagacgtt
3219061 cgtgggtgcc gccgcccgcg gcggccgccg cctggtgatc gccatgatgt acgggctggt
3219121 caaagagggc ggaccgacgt attgggatca ggctgcgacc ctgttcgact ggggtttcgc
3219181 cctcaacccg caggccagcg tcggctcgct ctagcaccgc gagcagacgt gggcgctggt
3219241 gcgcccatca tgttcttttg cgtctgctgg cgctcatagg ccggcggtca gcagcgccgt
3219301 cagcatggga atccgctgtt cctcgagttc gggctgcggc agtacccctc gcacaatggc
3219361 ggcgccgtcg aagacgttgg tcatcaacgc cacgatgacc ggaaatgtct cctccggaaa
3219421 gctctcggca cccggcagag cacgcgcggc gtcgtggatc ttcgcgctgt actgccccag
3219481 cacattctgc agcgtctcct tgagcttctc gtcggtgcgc gcggcgacca taagctcgta
3219541 gagcaccgca ttcgtggagc cggccgtgat gtcccgcaaa atcgtcagcg ccgccggaag
3219601 cgccggccga tcggccggta tttcggcgac ttgcttggtg aacgtttcca gctgacggcg
3219661 caacacctcg tatgccgtgg ccgccatgaa atcacccatc gtttcgaagt gccggaacag
3219721 ggcgcctacc gacaccccag cccgcttggt gatcacggca gccgatgccc gcgcgtagcc
3219781 gacctcgatg atcgtgtcga tgctggcctg cagaagccgt gcaacggttt cttcgcggcg
3219841 ctgctgctgg gtcctggcca tgtcaggcag aacggctcag agcggcgccg agctcacccg
3219901 cccgcaggta gcgacccgac ttcacgttct gcccgtagcc gtcgcggaac tgacctccga
3219961 actggcctcc gcggaatacc acggtgccgc ccacgcccgt cgcaaccacg gtcgcatcgt
3220021 tgcggttgac catgcgtcgc agaccgccat agtagggcac cgcctcctcg tggtacccgt
3220081 ccaccgattc atctaggtgg gtagggtcaa tcaccgcgaa gtccgcacgg tcaccctggc
3220141 gcaacgtgcc cgcgcctata ccgaaccact cggccaactc accggtgagg cgatacactg
3220201 cccgctcgat ggacagaaac ggttgtccgg cccggtcggc gtctctggct cgtttgagca
3220261 gccgaagccc gaagttgtag aacgccatat tgcgcaggtg cgcgccggcg tcggagaagc
3220321 ccatgtggac actcggttcg gcggccagct tgttcagctg gttgggccgg tgattggcga
3220381 cgatggtggt ccatcggaca ttgcgctccc cgttgtccac cagcacatcg aggaacgcgt
3220441 ccagcgggtg cagcccgcgc tcgtcggcta ttgccccgaa actcttaccg atcaacgact
3220501 tatccgggca ttcgacgatc acggcgtcgt ggaagtcccg atgccacaac gaaggtccga
3220561 gcttgatgcg atcgaactcg cgccggaacg accggcggta agacctgtcg gccaggagct
3220621 cgttgcgctg cagttggtca cgcagatgaa gggccgccgt tccggcgccg aactcctcga
3220681 agaccggcag gtcgatgccg tcggagtaca gctcgaacgg gaccggcaga tgctggaatc
3220741 gcacctgaga gcctaagagc ttgttcagca cgcgggtgcc caacccgaac acgtgtaccg
3220801 ccagcggcat cgacttggcg tcggcggaca ccaacatgct cattcgaacg cccttgcgcc
3220861 ggttgaatat ccggctgctg gccaagaaaa acagcagcgc ggacaccggg ttgtcgacgt
3220921 cgggtgcgct ctgcagtatc cggccccggt ggcgcagcac cgagatcagc ttgcgacgct
3220981 cccgccaggt cgcgaaggtg gacggcagcg cacgcgagcg gaagcggtcg ccgtcgagct
3221041 tgtcgatagc ggcgtccatc ccggacatgc ccagcatccc ggcctcgagc gcctcatcga
3221101 gcagtttcgc catcttcgcc agctcggctt cggtgggccg gacggtgtcg tcggtggcac
3221161 gatcaaggcc cagtaccgcg gtccgcagat ccgaatggcc aagcagtgaa ctcacattcg
3221221 gcccgagggg cagggcgtcg atcgcttcga tgtactccgc gggcgtcgac cacgtctggt
3221281 tgtcccgcag ggcacccagg acaaattcgc ggggcaccgc ttcaacacgg ctgaacaggt
3221341 cggcggcatc ctcggagttg gcgtagaccg tcgacaacga gcagtttccc agcagcaccg
3221401 tggtgacacc gtggcgcacc gactcccgca aaccaggatc gagcaacacc tcggcgtcat
3221461 agtgggtgtg cacgtcgatg aagccaggca cgacccactt ccccgccgca tcaaccacct
3221521 ccgggcagcc ggtctcgtcc agtgcgccgg cagccaccgt ggccaccacg ccgtcgcgaa
3221581 tgcccagagt gcgagtcaat ggcgcattgc cggtgccgtc gaaccacagt ccgtcgcgaa
3221641 tgatcacgtc gtaggtcacc gtttcctcca gatcgttgag ttgccgccaa gctaacatag
3221701 atagcgatca ctcgcaatct ttttggctga cgccgcttcg ctgccgcggc gctggtcaag
3221761 tgggtgtcag cgaccgggcc ccggcgccgt tgtggtcggc ggcgtcaggg tggctgtgga
3221821 cgttgtatcg ggggtatcag gaatcgttgc tgggtccggc acggtgactg ccgggggaag
3221881 atcaccactg cggctggcca ccgcgggaat ccgaatgacc gctccttgtt gtccacattc
3221941 gttgctatgc acagtgacga ccatttcgcc gacgaggtcg ccctgcggtt gcggtcgcag
3222001 tgcgagcaac tgcgtcgtgg cctgtgtact cggcgagccg ttgggcccga cgcacgggaa
3222061 ctgcaccgtc tccggccgcg acttccactg gccctcgccg aactgcatga ggaacggcct
3222121 aacgggcgga gtcttggcct gggtgtggtc gttgtcgtcg agcatcgttg cggccgcgag
3222181 acattcggtc ggagtgcacg aagtgcggaa cgcccaccag gtgttcacgt ccggcggttg
3222241 cggcgtaggg gtgtagtcgt aggtctgctt tgagcgttgg atctcgatgc ggtatgtgcc
3222301 gtccagtggg accggcgcgg tgaccgcgac ggtggtcgtc ggggcgctgg gcacagccga
3222361 cccactggtc ggcgggcgcg cgacttcggt ggcggtcgtg ttcgtcttgc gcccaatcac
3222421 gatgccgacc gcgaacaggc cagccaatag caacaccgct accgcaccga ccaggatccg
3222481 gcgtggccgg cgcctggtgg ggctcgccgg agccttggtg gcggtggaga agttgtccag
3222541 gcggcgcgcc agcaccccgg ccgctgactg cagcatcgag ccgcgccgtt ggggggtcgg
3222601 ggccgccggc gccggtgccc gggcggatgg ttctttgcag tcgacggcct cgggccaacc
3222661 ataagccggg tagtcgacga catacgcttc ctcaccggcc gccgcggtga cctcagaagc
3222721 gtcgacaccc cccgagctct gatcagcgat cgcgacgccg gcctgttcgt tcatcgcgtc
3222781 ggcgaactcg cggcagctgc cgaaccggtc cgcgggcgct gtggcgagcg cacgcgagag
3222841 gacaccgtcg aggcgtgcca ggtccgggcg gaaggcggag agcttcggtg gctgcagcgg
3222901 tccggtgtgc gaacgatcaa ccggcggcgc accggcgaac aggtgtatgg cggtaagcgc
3222961 caacgcgtac tgatcggcac gcccgtcaac gtcggccccc gccgacagtt cgggcgccgg
3223021 atagctgggt tggctggcaa ttccgaagtc ggccaacagg atccgttggt cgccagcact
3223081 ctgactggtt agcacgacgt tggcggggtt gacgtcacga tgcagcaggc cgcgctggtg
3223141 ggcgtagtcg agagctccgg ctacggcagt gacgatggcg agtacctcac caaccggcaa
3223201 gaccgccgga aaccggtcgg ccatatgctg cgtggcgtcg atgccatcga cgtagtccat
3223261 cgcaatccac agctgcccgt cgaactcacc gcgatcatga acctccagga tgtgcgggtg
3223321 aaatagccgc gcggcaacct cggtctcccg ttgaaatcgg cggcgaaatt cgtcgtccgc
3223381 agccatcgcc ggcgaaagca ccttcagcgc ctgccagccg gggaatccgg gatgttgcac
3223441 gaggtagacc tcacccatcg cggaacaacc cagcatccgc acgacggtgt agccggcaaa
3223501 ggtcacgccg ctggccaacg ccattggccg atagtaaccg cgttcggcac ggcccgcgcg
3223561 gccaaagcta gggcccaaaa gtcctgccgc gcaaaatcac cagatcggga tgctgcagca
3223621 cacccggacc ctgccgcgga tcctgggcgt agcacaacag gtcggccgat gccctatcgt
3223681 ccagcccggg ccggcccagc cagcgtcgag catcccagca cgccgcgccc aacgcctcgt
3223741 gcgcggtcat cccaatcctc tgcagcgccg ctacctcgtc agcgatccgt ccgtgctcga
3223801 tcgtgctgcc cgcatcggtg cccgcgtata ccggcacccc cgcctcccgc gccgcagcga
3223861 cccgcccata gccgcgggca tacaggtcgc gcatgtgcgc ggcataggtt ggatagcgcc
3223921 ctgccgcatc ggcaatgccc ggaaagtttt ccaggttgat cagcgtgggg accaacgcgg
3223981 tgccgtgctc gagcatcaag gcgatggtgt cgtcggtgag gccggtgccg tgctcgatgc
3224041 agtcgatgcc ggcgttgatc aagccgggca gcgcgtcctc gctgaaaacg tgcgcggtga
3224101 cccgggcgcc ctgagcgtgt gccgtgtcga tggcggcttt gagcacgtca tcggaccaca
3224161 acggggcaag atcgccgatt tgacggtcga tccagtcacc gaccagcttg acccagccgt
3224221 caccgcggcg ggcctgctcg gctaccgctg ccggcagctg ggattcgtct tcgagctcga
3224281 ccgcgaagcc ggcgatgtaa cgcttgggtc tggccaggtg ccgtccggcg cggatgatgc
3224341 ggggcaggtc ttcgtggtcg tcaaggccgc gggtgtcggt cggcgagccg cagtcccgca
3224401 acagcagcgc gccgacgtca cgttcggtct cggcctgagc gatcgcctcg tcgagttcga
3224461 cgttgccgtg tttcccaagc ccgacatggc agtgcgcgtc gaccagcccg ggcaggatcc
3224521 agccgccgtc aaagacggtg tcggctcctg ccaccggttc ggtgctaatg cggccgtcga
3224581 cgatccacag ttggatcgcc gtctcgtcgg gcaggcccaa acctcgcacg tgcaggcgca
3224641 cggcgcggct acggggcctg atggtgtcga cccgcttcac ccggctccgc cgcactcgcg
3224701 atcgccacta cttcttgcct gggaacttca gcttggacag gtcgaagtcg gccaggccgg
3224761 gcggcagctc gtcgagacct ttgggcatct gtgagagatc agggagcccc ccaggtagcc
3224821 cagccaagcc cggcatcccg ggcacgccga acgggctctt gaccttcggc ggcgtcggac
3224881 cgcgcgtccc cttcttactc ttcttgccgg atttgccttt tgcgcccttg ctctttcgcg
3224941 tcgcggattt gcgccctatg cccggtatgc ccatgccccc gagcatggac gacatcatct
3225001 tgcgggcttc gaagaagcgc tcgaccagct ggttgacctc ggacaccgtg acgcccgagc
3225061 cgttggcgat gcgcagccgc cgcgaggcat tgatgatctt ggggtctgcc cgttcctgcg
3225121 gcgtcatgcc gcgaatgatg gcctggacac gatcgagttg tttgtcgtcg acctcggcca
3225181 acgcgtcctt catctgagcc gcgccgggca gcatgcccag caggttgccg atcgggccca
3225241 tcttgcgtac cgcgagcatc tgctcgagga agtcctccag ggtcagctcg ccggcgccga
3225301 tcttggctgc ggcctcctcg gcctgttgtg catcgaagac ctgctcggcc tgttcgatca
3225361 ggctcagcac atcgcccatg cccaagatgc gactggccat ccggtccggg tggaagacgt
3225421 cgaagtcctc cagcttctcc ccggtggagg cgaaaaggat tggaacaccg gtcacttcgc
3225481 gcaccgataa cgcggcacca ccgcgggcgt caccgtcgag cttggtcaag gccacaccgg
3225541 tgaacccgac gccctcgccg aacgccgcag cggtggtgac cgcgtcctgg ccgatcatcg
3225601 cgtccaggac gaacagcacc tcgtcggggt tgatggcgtc gcggatggcc gcggcctggg
3225661 ccatcagctc ctcgtcgatg cccagtcgtc cggcggtgtc gacgatgacg acgtcgaagt
3225721 gcttggcccg ggcctcggcc agcccggccg ccgccaccgc aaccgggtca ccggggccgg
3225781 actccggcga ggcacccgga tgcggcgcga acaccggcac tccggcacgc tcgccgacga
3225841 cctgcagctg gttcaccgcg gccggccgtt gcaggtcaca agcgaccagc agtggcgtgt
3225901 gtccttgtcc acgcaggcgg gcggccaatt tgccggccag tgtcgtcttc ccggagccct
3225961 gcaggccggc gagcatcacg acggtcggcg gggtcttcgc aaacgccaac tcgcgggttt
3226021 cgccgccgag gatgcttatc agttcctcgt tgacgatctt gacgacctgt tgagccgggt
3226081 tgagggcact tgacacctcg gccccgcggg cgcgttcttt gatccggtgg atgaatgccc
3226141 ggaccaccgg tagcgaaaca tcggcttcca gcagcgccaa acgaatttcg cgggtagtgg
3226201 catcgatatc ggcatcggtc agtcggccct tgccgcgcag cccctgcagg gcggcggtca
3226261 aacggtcaga cagcgattca aacacgcccg ccagcctaat ggtgatcgcg agcgccgcgc
3226321 agcggcaccg ttatccgttg actctgcgtc caccacgcaa aagtgcgagt aacccgcctg
3226381 gtggacgcag agtcaacacg atgcgacgtc ggacctgcgc cgaaaagcgt tgccatgcta
3226441 catttcaccg ccgccacctc acggttccgg ctggggaggg agcgggcaaa ttcggtccgt
3226501 agcgacgggg ggtggggagt cttgcagccg gtcagcgcga ccttcaaccc tccgttgcgg
3226561 ggttggcagc gccgggcgct ggtgcagtac ctgggcaccc agccgcggga tttcctcgcg
3226621 gtggccactc ccggatctgg caagacatcg ttcgcgctgc ggatcgcagc cgaactactc
3226681 cgttaccaca ctgtcgagca ggtcaccgtc gtcgtgccca cagagcacct caaggtgcag
3226741 tgggcgcatg ctgcggcagc acacggcctt tcccttgacc caaagttcgc caactccaat
3226801 ccgcagacct caccggagta tcacggcgta atggtcacct acgcccaggt cgcttcgcat
3226861 cccacgctgc accgagtgcg taccgaagcg cgcaagacgt tggtggtctt cgacgagatc
3226921 caccacggcg gcgacgccaa gacctgggga gacgccatcc gggaagcttt cggtgacgcc
3226981 acccgccgcc ttgccctgac gggtacaccg tttcgcagcg acgacagccc aatcccgttc
3227041 gtcagctacc agcccgacgc ggatggcgtg ctgcgttctc aggctgacca cacctacggc
3227101 tatgcggaag ccctcgctga cggtgtcgtc cggccggtgg tcttcctcgc ctattcgggg
3227161 caggcgcgct ggcgggacag cgccggcgag gagtacgagg cgcgactggg cgagccgctg
3227221 tctgccgagc agaccgcgcg ggcgtggcgc acagcgctcg acccggaagg cgagtggatg
3227281 ccggcggtga tcacggcggc cgatcgacgg ctccgacaac tgcgtgcgca cgtacccgac
3227341 gcgggcggca tgatcatcgc ctcggatcgc accacggccc gcgcttatgc ccgcctgctc
3227401 accacgatga cggccgaaga gcccacggtc gtgctctccg acgaccccgg atcgtcggcg
3227461 cgtatcacgg aatttgccca gggcaccagc cgttggctgg tcgcggtccg catggtctcc
3227521 gaaggtgtcg acgtgccccg gctttcggtc ggggtttacg ccaccaacgc ctccacgccg
3227581 ctgttcttcg cacaggccat cggtcggttc gtgaggtccc gccgaccggg tgaaaccgcg
3227641 agcatcttcg tgccgtcggt gcctaacctg ctgcagctgg ccagtgcgtt ggaggtgcag
3227701 cgtaaccacg tgctgggccg accgcaccgc gaatcggccc acgatcccct cgatggtgat
3227761 cccgccacca ggacgcaaac cgagcggggc ggcgcggagc ggggctttac cgcgttgggg
3227821 gccgatgcgg aactcgatca ggtcatcttc gacggttcct cgttcggcac cgccacccca
3227881 accgggagcg acgaggaggc cgactaccta ggcatccccg ggctgctcga tgccgagcag
3227941 atgcgcgccc tgctgcaccg ccgccaagac gagcagctga ggaaacgggc tcagcttcag
3228001 aaaggggcca cccagccagc aacgtcgggg gcttcggcat cggtgcatgg ccaactgcgc
3228061 gacctgcgcc gcgagctcca cacgctggtg tcgattgcgc accaccgcac cggcaaaccg
3228121 catggctgga tccacgacga acggcgccgc cgttgtggcg ggcctccgat cgccgctgcc
3228181 acccgcgctc agatcaaggc acgcatcgat gcgttgcgac agctcaactc cgagcggtca
3228241 tgagcgtgcg atcctaatcg ccgacgggtt cgtcgaccac aacgtcgacg ctggcgccca
3228301 acacctccag caggtgttgc tcgaccgcgg ctctcgcgtc caactccgcg gggaccgtca
3228361 cacagaacac atcggccgcg gtcgatccga acgtattgac cttcgcccag acaatgccgg
3228421 ctcccgcgcc ctccagcgcc ccggccagca acgcgagcaa acccgcccga tccatggccc
3228481 gaacttcgag gatcagcttg gccggcgcgg cggtgtcgag ccacaggatg cggggcggag
3228541 cggccgtacg agtcacgggc accccggcct gcacgtcccc ggcccgagcg gataccaagc
3228601 tggcggcatc gctgtcccgc ttctgcagca tgcccagcac gtcgacgtcg ccgttgaggg
3228661 caccgacaaa ctgctgacgc accaactccg ccgcgggcgg ggacccaaac agtggtgaca
3228721 ccacaaactc ggttatcgcg acaccctggt ggacgttgac cgacgccgaa tgtacgcgca
3228781 gcgagttcag cgccagcacc gcggcggctt tcgacaccag tccccgctcg tccggcgcca
3228841 ctattacggc gtcgatgcgt tcaccgtcgc gcggactaat ctccacatgc accccgtggt
3228901 cggccgccag cgaaagataa tggggtgcag tcggttcggc ttgaggcagc gactctccgg
3228961 ccatcaccat ccggcagcga cgcaccaggt catcgaccag tgacgccttc caatcgctcc
3229021 acaccccggg gccggtggcc ttcgagtccg cctccgacag ggcgtgcaaa acttcgagca
3229081 gttgcggatc cccacccagc gcctcggaca ccgcctcgat ggttttgggg tcgtttaagt
3229141 cacgtcgggt tgccgtaatc ggcagcagca ggtggtggcg gaccagcttg gagagcgtcc
3229201 gcacgtccgg cggcgacaac cccagcctgg tgcaaaccgg gattaccaat tcggccccga
3229261 gcacactgtg atcggtgccc cgtcccttgc cgatgtcgtg cagcagcgcg ccaagcgcaa
3229321 gcaggtcggg acgtgccacc cgggtggcca gtggcgccgc atgcaccgcg gtctcgacca
3229381 cgtgtcggtc aaccgtccac ttgtgggcga cgtcgcgcgg cggaaggtcg cgaatgggct
3229441 cccattccgg caacaaccgg ccccagagcc cggttcggtc gagcgcttcg atggtagcca
3229501 ccgtggtggg gccggcggag agcacaacta gtaagtcgtc caatgcctct tgcggccagg
3229561 gagtcggcag atccgggacg ctggcggcca accggctcag ggtggcggcg ccaatgggca
3229621 atccggtgtc ggccgacgcg gcggccactc ggagcaccag gccgggatcg tgttcgggtt
3229681 cggcgtcgcg ggcgagcacg atttcgccgg catactcgac gacaccctcg tcgagcggtc
3229741 gccgctttgg ccgccgcacc aaggccgaga tgccgcgccg cggcaatgca ttcgccgcag
3229801 tccgcagccc ggcttcggcg tggtaaccga tggtgcggcc agcactcgac agtgtgcgcg
3229861 ccaaatcgaa tcggtcaccg aaacccaacg cggcgctgat ctcgtcggcg aactgggcca
3229921 gcaggtggtc gcgtccgcgg cccgacaccc ggtgcagttc ggtgcgcaca tccagcaagg
3229981 tgcgatacgc accgtccagc gaacccgccg gcaggtccgt gtggccgata ccgtgccggt
3230041 cgatgagctg ggcgagagcc agcgcgtcta gcaactggac gtcccgaagg ccgccgcgac
3230101 ccaatttgag atcgggctct gcgcgctgcg cgatccggcc acagcgccgc caacgcgcat
3230161 atgtcatttc gacgagttcg cccatgcggg aacgaattcc gttgcgccac tggcgtcgca
3230221 cgccgtcgat caacgcgaac gagagctgct gatcgccggc gatgtggcgg gcttccagca
3230281 tgcctagagc ggccatcaga tcggaattgg cgatggtcaa tgcctcacta accgttcgca
3230341 cactgtgatc gagccgaatg ttggcatccc acaacggata ccacaacctg tcggcgacgg
3230401 gccgcaagat gtcagcaggc ttgccatcgt gcaacagcaa cacgtccagg tccgaatacg
3230461 gcagcagctc gcggcggccg agcccgccga ccccgacgat tgcaaaacca ctggcatcgg
3230521 cgatcccgat ctcgtcggcc ttgtcgatca gccaagactc atgcagatcc agccacgtct
3230581 gccgcagccc gaccggatcc agctcgcgat ggttgccgga cagcagctcg cgtcgggcga
3230641 cagctaaatc gcttgcggca caaggacttt ctgcctccat ctccctcgct agcgctaatt
3230701 ggtgcggccg ggttggttca gcacagtgcg gctagtttca taacgcgtcg tgtccgcgtt
3230761 caccggtgcg cacccgcacg atggtgtcta ccggactcac ccacaccttg ccgtcgccga
3230821 tcttgccggt gcgcgccgcc cggacaatgc tgtccacgac cttgtcgaca atggaatcgt
3230881 caacaacgac ctcgatccga accttcggta cgaaatccac cgagtattcg gccccgcggt
3230941 aaacctccgt gtggcccttc tgccgtccgt atccctggat ttcactgacc gtcatcccca
3231001 gcactcccgc gtcctcgagg ctcgtcttga cgtcgtcgag cgtgaacggc ttcacgatcg
3231061 cagtgatcag cttcatttcg gctccgcctc cactttctgg cctatacgct cctgaatgcc
3231121 gttgcggcta tcctccacgg tgacccgcgg ggggagaacc gagccgctgg cgacggcgaa
3231181 atcgtagccg ctttccgcgt gctcagcctc gtcgatgccg gtgctctctt gctccgcgtc
3231241 aagcctgagc ccgatggtga atttcaggat caatgccaag atcagggtga tgattccaga
3231301 gtagacgaga acactgcagg caccgagcgc ctgtcgttcc agctgggcga agcctccgcc
3231361 gtaaaacaac cccttcgata ccccggccac accattaatt gccggagcct ccggagctgc
3231421 cagcagaccc accagcagtg tgcccaccag accaccaacc aggtgcaccc cgaccacgtc
3231481 gagcgaatca tcgaagccca gtttgaattt cagccccacc gccagcgcgc acagcacccc
3231541 ggccgacacg cctaccgcca aggcacccag gacattaacc gacgagcagg acggcgtgat
3231601 ggcgaccagt ccggcgacga tgcccgacgc cgcgcccagc gtcgtagcct tgccatctcg
3231661 gacgcgctcc gtgagcagcc agccaagcat ggccgcggcc gtcgcaatcg tggtggtgac
3231721 aaacgtcgcc ccggcaacac cgttggcggt cgtcgccgat cctgcgttga acccgtacca
3231781 gccgaaccac agcagggcgg ccccgagcat cacaaacggc agattgtgcg gtcgaaacag
3231841 cgtcgccggc caaccgcgtc ttttgcccag cacgatcgcc agcatcaagg ccgccacacc
3231901 ggcgttgata tgaaccgcgg tgccgccggc gaagtcgatg gcgtgcagct tgttggcgat
3231961 ccagccgccg tgctcagcgg cgaaaccgtc aaatgcgaag acccagtgtg cgaccgggaa
3232021 atagacgaac gtcgcccaca aaccggcgaa caacagccag gcgccgaact tcaaccggtc
3232081 ggccaccgcc ccggagatca gcgcaaccgt gatgatcgcg aacatcagct ggaatgccac
3232141 aaacacggtc gccggcaggg tacccgccag cggaatattc accgcggcgg tctgcgtgct
3232201 cggatcggca gcaacagcat tgacgccgat gagacctttg agaccccagt attggctcgg
3232261 gttgccggcg atgttgccaa cgtcatcacc gaacgcaatc gagtagccgt aaagcgccca
3232321 gagcaccgtc acgacaccca tcgcgctgat gctcatcatg atcatgttca ggacgctctt
3232381 ggaacgcacc atgccgccgt agaaaaatgc cagacccggc gtcatcaaca gcacgagcgc
3232441 ggaactcacc agcatccagg cggtgtcgcc gccatccgga acgcccatga tggggaattg
3232501 gtccactcgc tatcacctcc agtcgagcgt tggcacggcc ccagccttac gactgacgac
3232561 ctgatccaga accatgcgca ctagttgttg cggcgatggt gccgccatgt ttcatcagga
3232621 ttaacgtaaa acttgctgtg aaagagcttt ccgtggcgat cgcaagcgcg gcgcagccgc
3232681 gcgcagcggg tcgccaccat cagaccccgt ggcgatcgca agcgcggcgc agccgcgcgc
3232741 agcgggtcgc caccatcaga ccccgtggcg atcgcaagcg cggcgcagcc gcgcgcagcg
3232801 ggtcgccacc atcaaacccc gtggcgatcg caagcgcggc gcagccgcgc gcagcgggtc
3232861 gccacctcgg ctagccgagc agggcgtcga cgaatgcggc gggttcgaaa ggcgccaggt
3232921 catcggggcc ttcaccaagc ccgaccagct tcaccggcac cccaagttcc tgttgaacgc
3232981 ggaacacaat gccgcccttg gccgttccgt ccagtttggt gagcaccgcg ccgctgatgt
3233041 cgacgacctc ggcgaacact ctggcctgcg ccaacccgtt ctgtccgatc gtggcatcga
3233101 gcaccagcaa cacctcgtca acggacgctc gccgagtcac cacgcgcttg accttgtcca
3233161 gctcgtccat caggccaacc ttggtgtgca gccgcccggc tgtatcgatg agcacgacgt
3233221 ctgcgccggc ggcgatgccc ttgtcgacgg cgtcgaacgc caccgatgcc gggtcggcgc
3233281 cttcgggccc gcgaaccacc gctgcgccaa cccgcgccgc ccaggtctgt agctgatcgg
3233341 cggcggccgc acggaaggtg tcagccgcac cgagtacgac ccgtcggccg tcggccacta
3233401 gtacccgcgc caacttgccg accgtggtgg tttttccggt gccgttgacg ccgacgacca
3233461 gcaacaccga aggatggccg gcgtgcggta gcgcgcggat cgagcggtcc atgccaggtt
3233521 gcagttcgtt gatcaggacg tcacgcaata ccgcccgggc gtcggcctcg gtacgcacgt
3233581 tgccgctggc caggcggctg cgcagctgcg acaccaccga cgcggtggcc gccggtccca
3233641 ggtcggcgac cagcagggtg tcctcgacgt cttgccagga gtcctcgtcc aggtcgccgc
3233701 cgccgatcag tcccaacagg ccgcgcccga gggcattctg cgatctggcg agccgtccgc
3233761 gcagtcgttc caatcgacct tcgggcggcg cgatggcgtc agcctcgggg acctctggag
3233821 cctggggttc tggctcaaac tcgggaaggt gtacgtcggc gatcgtgcgc ttgggcgcgt
3233881 cgcgagggac ggtcgcatcg tcgcccacgg cgggcagtcc gctcgtatcg atccgctcgg
3233941 ccggctgggt cgtcggcgtc tgactaaacg tgatgccaga cgatgcggtg taaccgcctg
3234001 agcggtcgac aacgccgcgc tcgggccgag gcgacagact gatgcgccgc cgacggtaga
3234061 gcaccagccc cagggtcagc gcagcgatga cgaccagggc ggcgatgacc gccgtggcga
3234121 tccacaaacc ttcccacacg ctgacaatcc ttccaggggt cgcttgcccc gatgcttagg
3234181 gacgaaccct acgaggaatt ggtaaccagc tgatccacct gctgaccgcg catgcgctgc
3234241 gagatgaccg cggtgatgcc gtcgttctgc atggttacgc cgtacagtgc gtccgcgacc
3234301 tccatcgtcg gcttctggtg ggtgatgatg atgatctgcg actgctctcg cagctgttcg
3234361 aacaggctga gcagtcggcg caggttcacg tcgtcgaggg cggcctccac ctcgtccatg
3234421 atgtagaacg gcgatggacg ggcacgaaag atcgcgacca gcatcgccac cgcggtcagc
3234481 gccttctcgc caccggagag caaagacagt cgggtaatct tcttgcccgg cgggcgggct
3234541 tcgacctcga tgccggtggt gagcatgtcg tcgggctcgg tcagccgcag ccgtccttca
3234601 ccaccgggga acaatgcggt gaacacgccg cgaaattcgc gttccacgtc tacgaacgcg
3234661 tcattgaaca cctgcaggat gcgggcgtca acatcggcga cgacgcccag cagatccttg
3234721 cgggcagcct tgacatcctc gagttgggtg gacaggaaat tgtagcgctc ctccaaggca
3234781 gcaaactctt cgagcgccag cgggttgacc ctgcccaact cggcaagcgc acgctcggcg
3234841 cgtttggccc ggcgctcctg ggtaacccgg tcgaacggca tgggggcggg cgcaatcacc
3234901 tgctcgccgc gttcgcgggc ttgctcgaac tcagccatct cgagctcggt cggtggtagc
3234961 gccacatgtg gaccgtattc ggtgatcaag tcggccggcg ccattccgaa ctgctctagc
3235021 accatctgct caagctgctc gatacgcagc gccgcctgcg cgttagccag ctcgtcgcgg
3235081 tgcagcgaat cggtgagttc ccccactcgg gcgctcagcg tgttcacctc gtcgcgcacc
3235141 gcggccatcg ccgctaaccg ctgctgacgt tgcgcggccg acgcgtcgcg cagttgcgac
3235201 gccccgtcca ccgcccggtg caaccgcccg gccagcagcc gtccgcagtc ggcgaccgct
3235261 gcggccaccg cggccgcatg cagtcttgcg gcgcgtgctt gctgagcccg cacccgcgcc
3235321 tcacgttccg ccgcagccgc acggcgcagc gaatcggccc gcccgcgaac cgcgttggcg
3235381 cgttcctcgg cggtgcgcac cgccagccgg gcttccactt cgacaccgcg ggcgcgatcg
3235441 gcagcggcac tgatcgcctg gcggtcgatc ggttgggcca cctgcacccg ttgggtctcc
3235501 tgggccttac gcagctgggt ctcaagttgt atgacgtcgt cgagagtctg tgtgcgcacg
3235561 gcttcctgtt ccgtacgctg ctgcagcaac cggttccact cttcttccgc cgcgcgggcc
3235621 tcctgcccga ggcggcccag ctgctcgtac atcgccgaga tggccgtgtc ggattcgtta
3235681 agcgcggcca aggcttgctc ggccgcgtcc tggcgggcgg actgctcggt cagcgcaccg
3235741 gccagggccg cattcaattg cgccgccagc gcctcggcag cggccagctc actcctggcc
3235801 ttgtcgatct cggaggtgac ctccaaggtg gacagcttgc ggtccgatcc gccgctgacc
3235861 cagccggcgc ccaccagatc accgtcaacg gtgaccgcgc gtagctccgg acgaatctcg
3235921 accaggccca ttgcctcagt caggtcgttg accaccgcga cacccgaaag catggcgatc
3235981 atcgcgccaa ccaactgcgg tggagactcg accaggtcta gggcccactg ggcgccgcta
3236041 ggcagcatct cccccgaggc ggattggggg gcttgcgggg ccggccagtc actcagcacg
3236101 aggaccgcgc gaccgccgtc ggcttgtttg agtgcgctga cggcactacc cgcggcagtc
3236161 aggccgtcca ccgcaagtgc gtcggccgcc ggcccgagcg ccgcggccag tgccgcttca
3236221 tagccggaac gtaccttcac caattgggcg atcgaaccga aaagccctgc gccactgcga
3236281 ttgtgcgcca gccacgccgc gccgtccttg cgctgtagcc ccactgcgag cgcatcgatg
3236341 cgagcccgta gcgatgccac ctggcgttcg gcggcgcgtt cggcggattg cagctcggcg
3236401 acgcgttcgt cggccaaccg caacgcggcc acagtacgct cgtggtgctc atccaggccg
3236461 acctcgcctt gatccagttc accgatgcgg ccctgcacgg tttcgaactc ggctcgggtc
3236521 tgctgggcgc gcattgcggc atcctcgatc cgctcggaca accgtgccac gctctcatcg
3236581 atcgattcga cacgcgcccg catggtctcc acctggccag ccagccgcgc cagtccctca
3236641 cggcggtccg cctcctcccg gaccgccgcc aggtgtgccc ggtcggcctc ggcggcgcgg
3236701 cgctcccggt cggccagctc tgcacgggca gcatcgagtc gggcacgcgc cgcgtccagc
3236761 tccgctaaca gttgttgctc ggcgacggcc acctgctggg cctcggcttc tagctcctcg
3236821 ggctttctgg ggtcggtgtc gctgaccgct accggctcga tatcgagatg atgggcgcgt
3236881 tcgctggcga tgcgcaccgt agcgtccacc cgttcggcca gcgcagacag cccgaaccaa
3236941 gtgtgctgga tcgactcggc ccgcgtcgag agttcggcga ccgcggactc atgcgcggcc
3237001 agctcctcgg atgccaccgc cagccgggcg gcggcctcgt catgctcgcg gcgcatcgca
3237061 gcctcggcct gaaagaccgc ttcccgttcg gctctgcggc ttaccaagtc gtcggccgcc
3237121 aggcgcagcc gggcgtcgcg cagatcggct tggatggccg cggcacgctg ggccgcctcg
3237181 gcctgccggc ccagcggttt gagttgacgc cggagctcgg tggtcagatc ggtgagccgg
3237241 gccaggttcg ccgccatcgt gtcgagtttg cgcagagctt tttccttgcg cttgcgatgc
3237301 ttgagcacac cggcggcttc ctcgatgaac gcccgccgat cctcaggccg cgactgcaag
3237361 atctcctcga gcttcccttg cccaacaatc acatgcatct cacggccgat gccggagtcg
3237421 ctcagcaact cctgcacatc catcaaacgg caactgctgc cgttgatttc gtattcgctg
3237481 gcaccgtcgc gaaacattct tcgggtgatc gacacctcgg tgtattcgat aggcagtgcg
3237541 ttgtcggagt tgtcgatgct aacggtgact tcggcgcggc ccagcggcgc acgcgacgag
3237601 gtgccggcga agatgacgtc ttccatcttg ccgccgcgca gcgtctttgc cccctgctcc
3237661 cccatcaccc acgccagggc atcgaccaca ttggatttgc cggagccgtt gggcccaacg
3237721 acggccgtaa tgcccggctc gaagcgtaaa gtcgtcggcg cggcgaagga cttgaagccc
3237781 ttcaacgtca gactcttgag gtacacgagg ggccagatta ccgctcgctg aacccggtga
3237841 tctgctccgt cgactgcgac cagtcggcga cgactttggc gacgcggccc ggtgtcgtgt
3237901 cgccctgcag cagctgcagc agcttctggc acgcagcgcg cggaccctgg gcgaccacca
3237961 gcacgcgtcc gtcggcgtgg ttggccgcgt aaccggtcag gccgagctcc aacgctcggc
3238021 agcgggtcca ccagcggaaa ccgactccct gcacccaccc gtgcacccag gcggtcagcc
3238081 gcacgtcagg cgccgacatc gacgacctcc aagttgaccg tggtgcccga cttgagggtg
3238141 cgcccgacgg tgcacgccag ctccaccgcg cggttgatga ccaccagcag acgctccttt
3238201 tcgtcctcgg tgaggcccga caagtcgagc tccatggtct cctcgatcag gggatagcgc
3238261 tcctggtcgc ggtcggccgc accggatacc ttgaccaccg cctggtagtc gtcgccgagc
3238321 cgccgggcca gcggctggtc actggccatc ccgctgcatg cggcgagtgc gatcttgagc
3238381 agctctccgg gggtgaatac cccgtcgacg tcctcggagc caaccagcac ctgcgccccc
3238441 cgcgtgctgc gtccgatgta acggcgcgtg ccggtgcgct cgacccacag ttgcgtcatg
3238501 gcttctttct acccgggggt ctttgcgtcg agatcgacgg cagcgccccc gcgagagaga
3238561 gcatcgcgct gacgtcgatc tcgatgcgtc aacacccgcc ctactttcgg ggccgcggct
3238621 ggcatcgcgg gcagtagaac gacgagcggt tcataaacct ctcccggcgt atcaccgcgc
3238681 cgcagcgccg acagttttcg ccttcgcggc cataagcgtc cagcgaccgc tcgaagtagc
3238741 ccgactcgcc gttgacgttg acatacaaag agtcgaacga ggtgccacct ttcgccagcg
3238801 cttcgcgcat cacgtcggcg gcggcatgca ggaccgctcc cagacgccgg caccttagtg
3238861 tggcggcgac gtgggcgccg ttcaccttgg cccgccacag cgcctcatcg gcatagatgt
3238921 tgccgattcc cgacaccacc cgctgatcca gcagctggcg cttgagttcg gaatgcttgc
3238981 gccgcaacac tttaactaca gcgtcacaat cgaaccgcgg gtcaagcggg tcgcgcgcca
3239041 ggtgggcgac cggcaccggt accacgctgc cgtccaccgt caccaggtcg gcaagcagcc
3239101 accctccgaa ggtccgttgg tcagcgaagc tcagcacggt cccgtcgtcg agcagcgcgg
3239161 aaatccggac gtgagcggca cacggcaccg ccccgagcag catctgccca ctcatgccca
3239221 ggtgcaccac gagtgcggtg tccgtcggcc tatggacccc agccgtattg agtgtcaacc
3239281 acaggtactt gccgcgccga tcggttccgt tgatccgcgc tccccgcagc cgcgccgtca
3239341 gatccgcggg cccggcatcg tggcggcgca cagcgcgggg gtggtgcacc cgaacctcgg
3239401 tgatggtccg gccggtcacg tgagcctgca agccgcgccg caccacctcg acttcgggca
3239461 gctcgggcat ccagtgatga tcgcaagcgc ggcgaagccg ggcgcagcgg gtcatcacca
3239521 tcgaaccagt gatgatcgca agcgcggcga agccgggcgc agcgggtcat caccatcgaa
3239581 ccagtgatga tcgcaagcgc ggcgaagccg ggcgcagtcc cccgcaagcg ggaggtgccc
3239641 ccaggtcatc accatcgaac cagtgatgat cgcaagcgcg gcgaagccgg gcgcagtccc
3239701 ccgcaagcgg gaggtgcccc caggtcatca ccatcgaacc agtgatgatc gcaagcgcgg
3239761 cgaagccggg cgcagtcccc cgcaagcgcg gcaaagccgg cgcccccagg tcatcaccat
3239821 caatccagtt aggcggaggt tttgcccggc atggcgttgt cgagcacttc cagggctttc
3239881 caagcggccg ccgcggcttt ttgctcggct tcttttttgg accggcccac tcctgaaccg
3239941 tattcgctgt ccatcacgac aaccaccgcg gtgaattcct tatcgtggtc cgggccggtg
3240001 gaggtgacca ggtatgacgg cgcacccagc cctcgcgctg cagtcagctc ctgcaagctg
3240061 gtcttccaat ccaatcccgc acccagggtc ggcgcggcgt ccagcaacgg gccaaacagc
3240121 cgcaggatca cctcacgggc cttctccata ccgtgttgca ggtagatcgc gcccagcagc
3240181 gattccatac cgtcggccag aatgctggac ttgtcggccc cgccggtgtt cgcctcgccg
3240241 cgacccaata gcacgtgaac accgaggcct tccgcacaga ggcggcgtgc gacgtcggcc
3240301 agggcctggg tgttgactac gctggcccgc agtttggcca gatccccctc cgaccgatca
3240361 ggatgacgat ggaacagcgc gtcggtgatg gtcagcccta gcacggcatc gccgagaaac
3240421 tccaaacgct cgttggtcgg cagcccgccg ttctcgtagg cgtagctgcg gtgggtcaac
3240481 gccagtgaga gcagctcgtc cgggaggtcc acaccgagtg cgtcgagcag gggttgtcgt
3240541 gaccggatca tcgctcacct cgtaatgtgt cggactccgg cccgagcatt tcgaccaact
3240601 tcgcccaccg cgggtcgatc tgttcatggc gatgacctgg ctcgctggcc agcgggacac
3240661 cgcactgcgg gcaaagaccc gggcagtccg gccggcacac cggcgaaaac ggcaattcca
3240721 gaccgaccgc atcgatgatc ggctgctcga gatcgatggt ttcgtcgacg acgcgtccga
3240781 cctcgtcttc ctcggtggtc tcgtcggtgg cgctatccgg ataggcaaac agttcggtca
3240841 gggctacctg aacgcgaccc cgcaccgggc tgaggcaacg agcacactcg ccgacggtcg
3240901 gggcggccac ggtcccggtc accaacacgc cttcggacac cgactcgacc cgcagatcca
3240961 ggtccagaag ggcgccctgg tcaatcgcga tcagctccag cccgatgcgt gcggggctgt
3241021 gcacggtgtc atgcagctcg aacatcgctc ccggtcgtcg ccccaaccgt gcgatgtcga
3241081 ccgtcatcgg cgacgccaca tgtcgctgcg cagtgggacc gtgctgcctg gccataagag
3241141 aaatcctacg gcgcacgcca cccagatcca cgccgcgttg ggcgttggcc ggcgcttgat
3241201 ccttgcgccg ggtgaatggt gttagcgcac cgcgtagtcg tgagtgccgg ccgctgtgcg
3241261 gagctggtgg cgaccgcggc caacggaccg cagggtgccg ttgaggaatt cctcgaattc
3241321 ggcgagcttg ttgtcgacgt agatatcgca ttctccgcgt agccggtccg cctcggcgtg
3241381 cgccgtgtcg acgaggcggg tcgattccgc gttggccgcc gcaaccacct cgttctgcga
3241441 taccaggcgc tgctgctctt tgatgccctc ctgcacggct ttctcgtagg agatgttgcc
3241501 gttttcgatc agccggtcgc attcggcctg ggcgcgactg acgctggcct cgtattcgcg
3241561 tttcgcggcg gtggcgatgc gaatcgcctc ctcgcgtgca tcggcgacca ttcgctcgct
3241621 gtgctggcgt gcctcgctga ccatccgatc agcctgcgcc ttcgcgtcag acaggatccg
3241681 gtcagcctcg gtgcgggcgt ggttgagtat cgactccgcc tcagtggtcg ccgaggacac
3241741 catagagtca gcgtgcgtct tagcgtcctg caacatcgaa tcacgtgcgt cgaggacgtc
3241801 ctgcgcgtca tccagctcac cggggatcgc atccttgatg tcgtcgatca actccagcac
3241861 atccccacgc gggacgacgc aacctgccgt catcggcacg cctcgggctt cttcgactat
3241921 ggcgctcaat tcgtccagcg cttcaaagac tcggtacacg gccacaccct cctggcatct
3241981 tgcaagatcc ctgttgttac cagtgtgcct ggtgtttcgt ctgtgactgc actggtggcg
3242041 ccggtgtgtc gggacacaat ttcatattcg acgagcccgg gcgaccactc agatcacgcg
3242101 gcctgctggg cgcgtgtcgt agaccgttcg gcggctgacg ggtgagccta cgtcgtctgg
3242161 gcgatcttgc ccgagcgtgc cgacaacgta ggtgtcgatg ctggcccgtc acggaccacg
3242221 ctatggtggc tcggtgaacg ggcactcaga cgacagtagc ggcgacgcga agcaagccgc
3242281 acccacgctg tatattttcc cgcatgccgg cggcaccgcg aaagactatg tcgcattttc
3242341 ccgagaattt tccgccgacg taaagcggat tgctgtccaa taccccggcc agcacgatcg
3242401 ttctggcctg ccaccgcttg agagtattcc caccctcgct gacgaaatct ttgcaatgat
3242461 gaaaccgtcg gctcggatcg acgatccggt ggcattcttt gggcacagta tgggcggaat
3242521 gctagccttc gaagtagcgt tgcgatacca atcggcgggc catcgagtcc tggcattctt
3242581 tgtgtcggcc tgctcagcac cgggtcatat cagatacaag cagctccaag atttatcaga
3242641 tcgcgagatg ttggacttgt tcacccgaat gacaggaatg aatccagatt tctttaccga
3242701 cgacgaattt ttcgttggag cgctacccac gttgcgagcg gtccgagcca tcgccggtta
3242761 ttcctgccca ccagagacga agctctcgtg tccgatttat gcctttatcg gagataaaga
3242821 ttggatcgca acgcaagacg acatggatcc gtggcgcgat cggacgacgg aagagttctc
3242881 tatccgtgta ttccctgggg atcacttcta cctcaacgac aatttgccag agctagtcag
3242941 cgacatagaa gacaaaacac tccaatggca tgatcgagct tagctatgct ccggatgtag
3243001 ctggccgaag atccaactgg ccgaagggct cgggggtcaa cacctggaca gccattcgct
3243061 ggacatttgc tgaagattca ccgtacgtcg gcaccggtct ggagcggatg gcttcagaca
3243121 cacacggggg cggtggcggc cgaccggtca ccccgccccc gcccggtatg caccatctcg
3243181 ggtgcagccg aggcgtgttg ttaatctcgt cacaacggga cgccggtcac aagacgtgcg
3243241 acccagccgc cggcggcact ctgacctcgg ttcttacctg actaccaatt cgtcaccggc
3243301 atcgcacacg tcacaccaac cacagcggac gcggcacggc acgcggaagg gacgttagac
3243361 tcggctagca ccaccaccgt gcccaggcaa cgacgccggc cgtcgctaag aaatttggtt
3243421 gacttcatga ataaggccgc gcccgccccg acaaatgatt accttacatt tgcgggctag
3243481 gcatagcgga gcaggggttt tagtctaggg ggagatcggc tggcgctgcg cagacatgct
3243541 gcggaagcag aactgcgtaa tcgtcaggtg gcttggtcag ttcagaccgg cacgtttcag
3243601 agcggtgggg atgtcccgac gtgcgatccg acaggggttc gcagggtccg caaaaaacat
3243661 agtgaacgcc agaaagccga atgggagtac aaggcgatgc cggtgaccga ccgttcagtg
3243721 ccctctttgc tgcaagagag ggccgaccag cagcctgaca gcactgcata tacgtacatc
3243781 gactacggat ccgaccccaa gggatttgct gacagcttga cttggtcgca ggtctacagt
3243841 cgtgcatgca tcattgctga agaactcaag ttatgcgggt tacccggaga tcgagtggcg
3243901 gttttagcgc cacaaggact ggaatatgtc cttgcattcc tgggcgcact tcaggctgga
3243961 tttatcgcgg ttccgctgtc aactccacag tatggcattc acgatgaccg cgtttctgcg
3244021 gtgttgcagg attccaagcc ggtagccatt ctcacgactt cgtccgtggt aggcgatgta
3244081 acgaaatacg cagccagcca cgacgggcag cctgccccgg tcgtagttga ggttgatctg
3244141 cttgatttgg actcgccgcg acagatgccg gctttctctc gtcagcacac cggggcggct
3244201 tatctccaat acacgtccgg atcgacgcgt acgccggccg gagtcattgt gtcgcacacg
3244261 aatgtcattg ccaatgtgac acaaagtatg tacggctatt tcggcgatcc cgcaaagatt
3244321 ccgaccggga ctgtggtgtc gtggctgcct ttgtatcacg atatgggcct gattctcgga
3244381 atttgcgcac cgctggtggc ccgacgccgc gcgatgttga tgagcccaat gtcatttttg
3244441 cgccgtccgg cccgctggat gcaactgctt gccaccagcg gccggtgctt ttctgcggca
3244501 ccgaatttcg ccttcgagct ggccgtgcgc agaacatctg accaggacat ggcggggctc
3244561 gacctgcgcg acgtggtcgg catcgtcagt ggcagtgagc gaatccatgt ggcaaccgtg
3244621 cggcggttca tcgagcggtt cgcgccgtac aatctcagcc ccaccgcgat acggccgtcg
3244681 tacgggctcg cggaagcgac cttatatgtg gcagctcccg aagccggcgc cgcgcccaag
3244741 acggtccgtt ttgactacga gcagctgacc gccgggcagg ctcggccctg cggaaccgat
3244801 gggtcggtcg gcaccgaact gatcagctac ggctcccccg acccatcgtc tgtgcgaatc
3244861 gtcaacccgg agaccatggt tgagaatccg cctggagtgg tcggtgagat ctgggtgcat
3244921 ggcgaccacg tgactatggg gtattggcag aagccgaagc agaccgcgca ggtcttcgac
3244981 gccaagctgg tcgatcccgc gccggcagcc ccggaggggc cgtggctgcg caccggcgac
3245041 ctgggcgtca tttccgatgg tgagctgttc atcatgggcc gcatcaaaga cctgctcatc
3245101 gtggacgggc gcaaccacta ccccgacgac atcgaggcaa cgatccagga gatcaccggt
3245161 ggacgggccg cggcgatcgc agtgcccgac gacatcaccg aacaactggt ggcgatcatc
3245221 gaattcaagc gacgcggtag taccgccgaa gaggtcatgc tcaagctccg ctcggtgaag
3245281 cgtgaggtca cctccgcgat atcgaagtca cacagcctgc gggtggccga tctcgttctg
3245341 gtgtcacctg gttcgattcc catcaccacc agcggcaaga tccggcggtc agcctgcgtc
3245401 gaacgctatc gcagcgacgg cttcaagcgg ctggacgtag ccgtatgacg ggaagcatca
3245461 gtggtgaagc cgaccttcgc cactggctaa tcgactacct agtaaccaat atcggctgca
3245521 cacctgacga ggtggacccc gatctgtcgc ttgccgacct cggcgtcagc tcccgcgacg
3245581 cggtcgtact gtccggcgaa ctgtcagagc tgctgggcag gaccgtatcg ccgattgact
3245641 tctgggagca cccgacgatc aacgcgctgg ccgcgtatct ggccgcaccc gagccgagcc
3245701 ccgactccga cgccgcagtc aagcgtggtg cccggaactc actcgacgag ccaatcgccg
3245761 tcgtcggcat gggatgtcgt ttccctggcg ggatttcgtg cccagaagca ttgtgggact
3245821 ttctctgtga acgccgttcc tcgatcagcc aggtgccgcc gcaacgatgg cagcccttcg
3245881 aaggcgggcc acccgaggta gccgcggcgc tagcgcgcac tacacggtgg ggctcatttt
3245941 tgcccgacat cgacgccttc gacgcggaat tcttcgagat ctcccccagc gaagccgaca
3246001 agatggaccc ccagcaacgc ctgctgctgg aagtggcctg ggaagcgttg gagcacgcgg
3246061 gaatcccgcc cggcacgctg cgccgctcgg caacaggagt gtttgccggg gcatgcctga
3246121 gcgaatacgg tgcgatggct tccgccgatc tgtcgcaggt cgatggttgg agcaatagcg
3246181 gtggcgcgat gagcatcatc gccaaccgcc tctcgtattt ccttgacctg cgcggcccgt
3246241 cggtggcggt agacaccgca tgctcgtcgt cgttggtagc gatccacctg gcctgccaga
3246301 gccttcggac ccaggactgt cacctggcaa tcgcagccgg cgtgaatttg ttgttgtccc
3246361 cggcggtatt tcgcggtttc gaccaagtcg gcgccttgtc cccgacaggt cagtgccgtg
3246421 cgttcgatgc gaccgccgac gggtttgtcc gcggcgaggg tgccggggta gtggtgctca
3246481 agcggttgac cgatgcacag cgcgacgggg atcgggtgct tgcggtgatc tgcggttctg
3246541 cggtcaacca ggacggccga tccaacgggc tgatggcccc caacccagcg gcccagatgg
3246601 cggtgctgcg tgccgcctac accaacgcgg ggatgcagcc cagcgaggtc gactacgtcg
3246661 aagcgcacgg aacagggacg ctgttgggcg acccgatcga agcccgcgct ctcggaacgg
3246721 tgctgggtcg cggccggccc gaggattctc cgttgctcat cggctctgtc aagaccaacc
3246781 tcggtcacac cgaggctgcg gctggaatcg cgggcttcat caagacggtg ctggctgtgc
3246841 agcatggcca gattccgcca aatcagcact tcgaaaccgc gaacccgcac attcccttta
3246901 ccgacttgcg gatgaaagtc gttgacacac aaactgaatg gccggcaacg ggccatcccc
3246961 gccgtgccgg tgtgtcgtcg ttcggcttcg gtggcacaaa cgcgcacgtg gtgatcgagc
3247021 agggccagga ggtgcgcccc gcgcctggac aaggcttaag tccggcggtg tcgaccctgg
3247081 tagtggccgg caagactatg cagcgggtgt ccgcgaccgc ggggatgcta gccgattgga
3247141 tggaagggcc cggcgctgac gtggccttgg ccgacgtggc ccacaccctc aatcaccacc
3247201 gatcgcggca acccaagttc ggcacggtgg tggcccgtga ccgtacccag gcgatagccg
3247261 gattgcgtgc gctggccgcc ggccaacacg cccccggcgt ggtcaaccct gccgacggct
3247321 cgccggggcc gggcaccgtg ttcgtctact ccggccgcgg ttcacagtgg gctggcatgg
3247381 gccgtcaatt gttggccgac gagccggctt tcgcggccgc ggtcgccgaa ttggaaccgg
3247441 tgtttgtcga gcaagccggc ttttcgttgc acgacgtgct ggctaacggc gaggaactgg
3247501 tcggtatcga gcagattcag ctcgggttga tcgggatgca gctggccctg accgaattat
3247561 ggtgttccta cggggtgcgg cccgacctgg tgatcggcca ctccatgggc gaggtggccg
3247621 ccgccgtggt cgccggggca ctgaccccgg ccgagggtct gcgggtgacc gccacccggt
3247681 cacggctgat ggcaccgttg tccggccagg gcggcatggc actgctggaa ctcgacgcgc
3247741 ccactaccga ggcgttgatt gccgacttcc cacaggtgac gctcggtatt tacaactcac
3247801 cacggcaaac ggtgatcgcc gggcccaccg agcagatcga tgagttgatc gcccgggtgc
3247861 gcgcgcaaaa ccggtttgcc agtcgggtca atatcgaagt ggccccgcac aatccggcca
3247921 tggatgcttt gcagccggcg atgcgttcgg agctggccga tctgacccca cggaccccca
3247981 ccatcggaat catctccacc acctacgcag acttgcacac ccaaccggtc ttcgacgccg
3248041 aacactgggc caccaacatg cgcaaccccg tgcgcttcca gcaggccatc gcttccgccg
3248101 gtagcggcgc cgacggcgcc taccacacct tcatcgaaat cagcgcacac ccgctgctga
3248161 cccaggccat catcgacact ctgcacagcg ctcaacccgg agccagatac accagcctcg
3248221 ggaccctgca acgcgacacc gacgacgtcg tgaccttccg gaccaacctc aacaaggccc
3248281 acaccatcca cccaccgcac accccccacc cccccgagcc acatccgccc atccccacca
3248341 ccccgtggca acacacccgt cactggatca ccaccaaata tccggccggc tctgttggat
3248401 cggccccccg agcgggcaca ctgctcggcc aacacaccac cgtcgccacg gtctcagcga
3248461 gtccgccctc ccacctctgg caagcaaggc tggctccgga cgccaagccg taccagggcg
3248521 gtcatcgatt ccaccaagtc gaggtggtcc cagcttctgt tgtgctgcac acaatccttt
3248581 ccgctgcaac agaattgggc tactccgcgt tgtccgaggt ccgattcgag caacccattt
3248641 tcgccgaccg gccacgtcta atccaggtcg tcgccgacaa ccgggcgatc agcctggcct
3248701 cgagtccggc tgccggaaca ccctcagacc ggtggacgcg gcatgttacc gcacaacttt
3248761 cctcgtcacc gtcggattcg gccagcagct tgaacgagca ccatcgcgcc aacgggcagc
3248821 cgcccgaacg tgctcaccgc gacctgattc ccgacctggc cgagctgctc gcaatgcgcg
3248881 gcatcgatgg cctgcctttc tcatggaccg tcgcgtcgtg gacacagcac tcgagcaacc
3248941 tcacggttgc gatcgatctc cccgaagctc tgcccgaagg gtcgactggg ccgctccttg
3249001 acgccgcggt gcacctcgcc gcgctatcgg acgtcgctga ttcgcggctc tacgtgccgg
3249061 caagcatcga gcagatatcg ctcggcgatg tcgtcaccgg gccgcgtagc tcggtgacgc
3249121 tgaaccgcac cgctcacgac gacgacggga tcaccgtcga tgtcaccgtt gcagcccacg
3249181 gcgaagtgcc gtccctgtcg atgaggtcgc ttcgataccg ggctctggac tttggcctag
3249241 acgttggtag ggcgcaaccg cccgcgtcga ccggtccggt cgaggcctac tgtgatgcca
3249301 ccaatttcgt acacacgatc gactggcaac cgcagaccgt tccggacgcg acgcacccag
3249361 gggccgaaca ggtaacccat ccaggacccg tcgcgataat cggcgatgac ggcgcagcgc
3249421 tgtgtgagac cctcgaaggg gcgggctacc agccggccgt gatgtccgat ggggtgtcgc
3249481 aggcccgcta cgtcgtttac gtcgcggatt ctgatccggc tggcgccgac gagaccgacg
3249541 tcgacttcgc cgtccggatc tgtaccgaaa tcaccggtct ggtgcggact ctcgcggaac
3249601 gcgatgcgga taagcccgcg gcgctatgga tcctcacccg cggagttcac gaatcggtcg
3249661 ccccgtccgc gctgcgccag agtttcctgt ggggccttgc cggtgtcatc gccgccgaac
3249721 atcccgagct gtggggcgga ctggtcgatc tcgcgatcaa cgacgactta ggcgaattcg
3249781 ggccggcact tgccgaactg cttgccaaac caagcaagtc gatcttggtg cgtcgtgacg
3249841 gcgtggtgct cgccccggcc ttggctcccg tccgtggcga gccggcgcgc aagtccttgc
3249901 agtgcaggcc cgacgcggcc tacctcatca ccggcggcct gggcgccctt ggcctgctga
3249961 tggccgattg gctcgccgac cgcggcgctc atcgattggt gttgaccggc cgcacgccat
3250021 tgccgccacg gcgggactgg caactcgaca ccctcgacac cgagctgcgc cggaggatcg
3250081 acgcgatccg cgccctggaa atgcgcgggg tgactgtcga agccgtcgcc gccgacgtcg
3250141 gctgccgcga agacgtgcag gccctgttgg ccgcgcgcga ccgtgacgga gcggcaccga
3250201 tccgcgggat catccacgcc gcgggcatta ccaacgatca attggtgacg agcatgaccg
3250261 gcgatgcggt gcgacaggtt atgtggccga agatcggcgg cagccaggtc ctacacgacg
3250321 catttccgcc cggcagcgtg gacttcttct acttgaccgc ctcggctgcc gggatattcg
3250381 gcattccagg gcagggttcc tacgccgccg ccaattccta cttggacgcg ctggcgcggg
3250441 cgcgccggca acagggctgc cacaccatga gcctcgactg ggtagcctgg cgggggctcg
3250501 gattggccgc ggacgcccag ctcgtcagcg aagagctagc gcgaatgggt tcgcgtgaca
3250561 tcacgccgtc ggaggcattc accgcttggg aattcgtcga tggctacgac gtcgcgcaag
3250621 cggtcgtggt gcccatgccc gctccggcgg gcgccgatgg atccggtgcg aacgcttacc
3250681 tattgccggc gcggaactgg tcggtgatgg cagcgaccga ggtgcgatcc gagctcgaac
3250741 aggggttacg ccgcatcatt gcagccgagc tgcgagtgcc tgagaaagag ctggacaccg
3250801 accgcccgtt cgccgagttg ggtctcaatt cccttatggc aatggcgatt cggcgcgagg
3250861 ccgagcagtt tgtcggcatc gagttgtctg ccaccatgtt gttcaaccac ccaacggtca
3250921 aatcactcgc cagctacctt gccaaacgtg tggcaccgca cgatgtgtca caagacaacc
3250981 agatttccgc gctatcctcg tcggccggaa gtgtgttgga cagtctattc gatcgcatcg
3251041 aatcggcgcc gcctgaggcc gagaggtcgg tgtgatgcga acggctttca gccggatttc
3251101 cggtatgacc gcgcaacagc gcacctccct agccgacgag ttcgacaggg tctctcgcat
3251161 cgccgtggcc gagccggttg cggtggttgg catcggctgc cgctttccgg gagatgtgga
3251221 tggaccagag agtttctggg actttctggt cgcgggcagg aatgcgatct cgacggtgcc
3251281 ggcagatcga tgggacgcag aagcgtttta ccaccccgac ccgctaacac cggggcggat
3251341 gacgacgaag tggggcggct tcgtccctga cgtcgcgggc ttcgacgccg aattcttcgg
3251401 tatcacaccg cgggaagccg cggcgatgga cccgcagcag cgaatgctgc tggaggttgc
3251461 ctgggaagca ctcgaacatg ccggcatacc accggattcc ctcggcggca cccgaaccgc
3251521 cgtcatgatg ggggtctatt tcaacgagta tcagtccatg ttggccgcca gtccgcagaa
3251581 cgtagacgcc tacagcggga ccggaaatgc acacagcatc acggtgggtc gcatctccta
3251641 cctgttggga ttacggggtc cggcggtcgc ggtggacacc gcctgctcgt cgtcgttggt
3251701 ggctgtgcac ctggcgtgtc agagtctgag gctgcgcgag accgatctgg ctctcgccgg
3251761 tggagtgagt atcacccttc gcccagagac ccaaatcgct atctctgcct ggggattgct
3251821 gtccccgcag ggccggtgtg ccgcattcga tgcggcggca gacggatttg tgcgcggtga
3251881 gggcgccgga gtggtagtgc tcaagcggtt gacggacgcg gtgcgcgacg gcgaccaggt
3251941 gctggcggtg gtgcgcggtt cggcagtcaa ccaggacggc aggtccaatg gcgtaacggc
3252001 gccgaatacg gcagcccagt gcgatgtgat cgccgatgcc ttgcgatccg gcgatgtggc
3252061 gcctgacagc gtgaattacg tagaggccca tggaaccggc acggtgctgg gcgacccgat
3252121 cgaattcgag gccctggccg ccacgtatgg ccacggcggg gacgcatgcg cgttgggtgc
3252181 ggtgaaaacc aacatcggtc atctggaggc ggccgccggg atcgcggggt tcatcaaggc
3252241 gacgctggcg gtacaacgcg cgacgatccc gccgaatctg catttctcgc aatggaatcc
3252301 agctatcgat gccgcgtcga ccaggttttt cgttcccacg cagaactccc cgtggccaac
3252361 cgcggagggg ccgcgccggg cggcggtgtc gtcgttcgga ttgggcggga cgaacgcaca
3252421 cgtgatcatc gagcaaggta gcgagctggc tccggtatcc gaaggcggcg aggacaccgg
3252481 ggtgtcgacg ttggtggtga cgggtaagac ggcccagcgg atggccgcga cggcgcaggt
3252541 gctggccgac tggatggaag gtccgggcgc cgaggtggcc gtagctgatg tcgcccacac
3252601 ggtcaaccat caccgggccc gccaagccac gttcggcacc gtcgtagccc gtgaccgcgc
3252661 ccaggcgata gccggactgc gcgcgctggc cgccggccaa cacgctcccg gagtggtgag
3252721 ccaccaggac ggttcgccgg ggccgggcac cgtattcgtc tactccggcc gcggctcgca
3252781 gtgggccggg atgggtcgcc aattgttggc cgacgagccg gctttcgccg ccgcggtcgc
3252841 cgagctggaa ccggtgtttg tcgagcaagc cggcttctcg ctgcgcgacg tgatcgccac
3252901 cggcaaggag ctagtcggta tcgagcagat ccagcttggc ctgatcggca tgcaactgac
3252961 attgactgag ctatggcgct cctacggggt gcagcccgac ctggtgatcg gccactccat
3253021 gggcgaggtg gccgccgccg tggtcgccgg agcgctgact ccggccgagg gtctgcgggt
3253081 gaccgccacc cgcgcacggt tgatggcgcc attgtccggc cagggcggca tggcactgct
3253141 gggactcgat gctgcggcca ccgaagcgtt aatcgcggac tacccgcagg tgacagtggg
3253201 gatctacaac tcgccgcggc agaccgtgat cgccgggccg accgaacaaa tcgatgagtt
3253261 gatcgcccgg gtgcgcgcgc aaaaccggtt tgccagtcgg gtcaatatcg aagtcgcccc
3253321 gcacaatccg gccatggatg cgctgcagcc ggcgatgcgt tcggagctgg ccgatctgac
3253381 cccacggacc cccaccatcg gaatcatctc caccacctac gcagacttgc acacccaacc
3253441 gatcttcgac gccgaacact gggccaccaa catgcgcaac cccgtgcgct tccagcaggc
3253501 catcgcttcc gccggtagcg gcgccgacgg cgcctaccac accttcatcg agatcagcgc
3253561 acacccgctg ctgacccagg cgattgccga caccttggaa gacgcgcacc gcccaaccaa
3253621 gtccgcagcg aaatacttga gcattggcac cttgcagcgt gatgccgatg acacggtcac
3253681 cttccgcacc aacctctaca ccgccgacat cgcccaccca ccgcatacct gtcacccgcc
3253741 cgagccgcac cccaccatcc ccaccacacc ctggcaacac acccaccact ggatcgccac
3253801 cacgcacccg agcacggcag cgccagaaga tccgggcagc aataaggttg tggtgaacgg
3253861 acaatcgaca tccgagagcc gtgcgctcga agactggtgc caccagctgg cctggccgat
3253921 ccgcccggca gtcagcgccg acccgcccag caccgccgcc tggctcgtgg tggcagacaa
3253981 cgaactctgc cacgagctgg cccgtgcggc cgattctcgg gtagacagcc tctcgccgcc
3254041 ggcgctcgca gcaggcagcg atccggccgc actgctcgac gcgctgcgcg gtgtggacaa
3254101 cgtgctctac gctccacccg tccccggtga actcctcgat attgaatcgg cctaccaggt
3254161 tttccacgca acgcgacggc tagccgccgc gatggtcgcc agcagcgcca cggctatttc
3254221 cccgccgaag ttgttcatca tgacccgcaa cgcccagccc atctcggaag gcgaccgagc
3254281 caaccctggc cacgctgtgc tgtggggtct cggccggtcg ctggcactag agcatcctga
3254341 aatctggggc ggcataatcg atctcgacga ttcgatgccc gcagagctgg ccgtgcggca
3254401 tgtgctgact gcagcccacg gtaccgacgg ggaggatcag gtcgtatacc ggtcgggcgc
3254461 acgccatgta ccccggctgc agaggcgaac tcttccgggg aaaccggtca cgttgaatgc
3254521 cgacgccagc cagctcgtca tcggtgcgac cggcaacatc ggaccgcatc tcatccgaca
3254581 gctcgcgcgg atgggggcta agacaatcgt cgcgatggct cgcaagcccg gcgcgctcga
3254641 cgagttgacc caatgtctcg ctgcgaccgg aacagatctc atcgcggtgg ccgccgatgc
3254701 gaccgatccc gccgccatgc aaaccctgtt cgaccgattc ggcacggagc taccgccact
3254761 ggagggaatc tatctggcgg cctttgcggg ccgcccagcg ctgctgagcg agatgaccga
3254821 cgacgacgtg accaccatgt ttcgtcccaa gttggacgcc ttggcgttgt tgcaccgacg
3254881 gtcactgaag agcccagtgc gccacttcgt tttgttctct tcggtgtcag gtctgctggg
3254941 ttctcgatgg ctcgcccatt acaccgcgac cagcgccttc ctggacagct tcgccggcgc
3255001 gcgtcgcacc atgggcctgc cggccaccgt cgtcgactgg ggactgtgga agtcgctggc
3255061 cgatgtgcaa aaagacgcga ctcaaatcag cgcggaatcc gggctgcaac ccatggctga
3255121 cgaggtggcc atcggcgcgc taccgctggt gatgaacccc gatgcggcag tcgcgaccgt
3255181 ggtggttgcc gcggactggc ccttgttggc cgcggcatat cgaacgcggg gagcccttcg
3255241 catagtcgac gacctgttgc cggcaccgga agacgtcggg aagggcgaaa gcgaattccg
3255301 cacatcgttg cgtagctgcc cggcggagaa acgacgggac atgttgttcg accatgtggg
3255361 cgccttggcc gccacggtga tgggaatgcc gcccacggag ccgctcgatc cgtcggccgg
3255421 cttcttccaa ctcggcatgg actcgctaat gagcgtgaca cttcagcggg cgttgtcgga
3255481 aagcctgggc gagttcttgc cggcgtccgt ggttttcgac tatccgaccg tttacagcct
3255541 caccgactac ctggccaccg tcctgcctga gctcctcgaa attggggcaa ccgcagtcgc
3255601 aacccagcaa gccaccgact cctaccacga actgaccgaa gccgagttgt tggaacaact
3255661 ttcggaacga ctaagaggaa cacaatgacc gcagcgacac cagatcgccg agcgatcatc
3255721 accgaggcgc tgcacaagat cgatgatctc acggcgcgcc tggaaatcgc cgaaaaatcc
3255781 agcagcgaac cgatcgcggt gatcggcatg ggttgccggt tcccgggcgg ggtcaacaac
3255841 cccgaacagt tctgggattt gttgtgcgcc ggccgaagcg gcatcgtccg ggttcccgcg
3255901 cagcggtggg acgccgacgc ctactactgt gatgatcaca ccgtgccggg gaccatctgc
3255961 agcaccgaag gcggttttct caccagctgg cagccagatg agttcgatgc ggagttcttc
3256021 tcaatctccc cgcgcgaagc ggcggcgatg gacccgcagc agcgattgtt gattgaagtt
3256081 gcgtgggaag cgctagaaga cgcgggcgtc ccgcaacaca ccattcgcgg tacgcaaacc
3256141 tcggtattcg tcggtgtcac cgcctacgac tacatgctca cgctggcggg ccggctacga
3256201 cctgttgacc tcgacgcgta catcccaacc gggaactcgg cgaacttcgc cgccggacgg
3256261 ctggcctaca tcctcggggc acgcggaccc gcggtggtca tcgacacggc ctgctcatcg
3256321 tcgttggtgg cggtgcacct ggcatgccag agcctgcgcg ggcgggaaag cgatatggcg
3256381 ttggtgggtg gaaccaacct tttgctgagc ccgggaccca gcatcgcttg ctcgcgatgg
3256441 gggatgctgt caccggaggg gcggtgcaag accttcgatg cgtccgccga tggatacgtg
3256501 cgcggcgagg gtgccgcggt ggtggtgctc aagcggctgg atgacgcggt gcgcgacggc
3256561 aaccgcattc ttgccgtggt acgcggttcg gcggtcaacc aggacggtgc cagcagcgga
3256621 gtgaccgttc ccaacgggcc agcgcaacag gcgttgctcg ccaaagcatt gacgtcgtcg
3256681 aagttgacag cggccgatat cgactacgtc gaggcccatg gaactggtac tccgctgggc
3256741 gacccgatcg aactcgattc actgagtaag gttttcagcg atcgagcggg ttcggatcag
3256801 ttggtgattg gatcggtgaa gaccaatctc ggtcacctgg aagcggcggc cggtgtcgcc
3256861 gggctgatga aagccgtgct cgcggtacac aacggctaca ttccgcggca tcttaacttc
3256921 caccagctga caccacatgc aagtgaggcc gcatctcggc tgaggatcgc cgccgatggt
3256981 attgactggc caaccaccgg tcgacctcgc cgggcggggg tgtcgtcgtt cggcgtcagt
3257041 gggacgaatg cacacgtggt gatcgagcag gcacccgatc cgatggccgc tgcgggaacg
3257101 gagccgcagc gcggccccgt tcccgcggtg tcgacgctgg tggtgttcgg caagaccgca
3257161 ccgcgggtgg ctgcgacggc atcggtgctg gcagattggc tggacggccc cggcgcggcg
3257221 gtgccgctgg ccgatgtcgc gcacaccctc aaccatcacc gggcccgtca gaccaggttc
3257281 ggcacggtag ccgctgtcga tcggcgccaa gcggtgatcg ggttacgcgc gctggccgcg
3257341 ggtcaatccg cccccggggt ggtggcaccc cgcgaaggct ccatcggagg cggcacggtg
3257401 ttcgtctact cgggacgagg atcgcagtgg gccggaatgg ggcgccaact gctggccgac
3257461 gagccggcat tcgccgctgc catcgccgaa ctggagccgg aattcgttgc tcaaggcggg
3257521 ttttcgctgc gcgacgtgat cgccggcgga aaagagttgg ttggcatcga acagatccag
3257581 ctgggactga tcgggatgca gctggcgctg accgcgttgt ggcgctcata cggcgtgaca
3257641 cccgatgcgg tgataggtca ctcgatgggc gaagtggccg ccgcggtggt ggccggggcg
3257701 ctgaccccgg cccagggatt acgggtgacc gcggtccggt cgaggctgat ggcgccgctg
3257761 tccgggcagg gcacgatggc gttgctggaa ctcgacgccg aagccactga ggcgctgatt
3257821 gccgactacc ccgaggtgag cctggggatc tatgcctccc cacgccaaac cgtgatttcc
3257881 gggccgccgc tattgatcga cgagctcatc gacaaggtgc gccaacagaa cggcttcgct
3257941 acccgagtca acatcgaggt ggccccccac aacccggcca tggatgcact gcaaccggcg
3258001 atgcgttcgg aattggccga tctcaccccg caaccgccga ccatcccgat catctccacc
3258061 acctacgccg acctcggcat ttccctgggt tccggcccca ggttcgacgc cgagcactgg
3258121 gcaaccaaca tgcgcaaccc ggtacggttc caccaggcca tcgctcatgc cggcgccgat
3258181 caccacacct tcatcgagat cagcgcccac ccgctgctga cccactcgat cagcgacacc
3258241 ctgcgcgcca gctacgatgt cgacaactat ctgagcatcg gcaccttgca acgcgacgct
3258301 cacgacaccc tcgagttcca cacgaacctc aacacgaccc acaccaccca tcccccccag
3258361 actccccacc cccccgaacc ccaccccgtg ctgcccacca ccccatggca gcacacccag
3258421 cactggatca ccgccacgtc ggccgcttac cacaggcccg acacccaccc gttgcttggc
3258481 gtcggtgtca ccgaccccac taacggcacc cgggtttggg aaagcgagct cgaccctgat
3258541 ctgctgtggc tcgccgatca cgtcatcgac gatctcgttg tgctgcccgg ggcggcctac
3258601 gctgagatcg cgctggcggc cgcgaccgac accttcgcag tcgagcaaga tcagccctgg
3258661 atgatcagcg agctcgacct tcggcagatg ctgcatgtga ccccaggcac cgtgttggtc
3258721 accacgctca ccggcgacga gcagcgatgc caggtcgaaa tacgcacccg cagcgggtct
3258781 tcgggatgga ccacccacgc caccgccacc gttgcccgcg ccgagccgtt agcaccgctg
3258841 gatcacgaag gacagcggcg cgaggtaacc actgccgacc tcgaggacca actggatccc
3258901 gacgacctgt atcagcgcct gcgcggcgcc ggccaacagc acggacccgc gtttcaaggc
3258961 atcgtggggc tggccgtcac gcaagctggc gtggcccgtg cgcaagtacg gctacccgca
3259021 tcggccagaa cgggttcccg tgagttcatg ctgcacccgg tgatgatgga tatcgcgttg
3259081 cagacactgg gagccacccg gacggcgacc gatctggccg gcggccagga cgcccggcag
3259141 ggcccatctt ccaactcggc cttggtggta ccggtgcgtt tcgccggtgt ccacgtgtac
3259201 ggcgatatca cccgcggggt tcgcgcggtc ggctctctgg ccgcagccgg tgaccggctg
3259261 gtcggcgagg tagtcctgac cgacgcgaat ggccaaccgc tgctggtcgt cgatgaagtc
3259321 gagatggcgg tgctcggatc cggcagtggc gcaacggaac tcaccaaccg cctattcatg
3259381 ttggagtggg agcccgcacc gctggaaaag accgccgagg ctacgggtgc cctgttgctg
3259441 atcggtgacc ccgccgcggg tgacccgctg ctgcccgcgc tgcagtcgtc gctgcgcgac
3259501 cgcatcaccg acctcgagct ggcatccgcg gccgacgaag ccacgctgcg cgcggcgatc
3259561 agccgaacct cctgggacgg gatcgttgtg gtctgtccgc cccgagcgaa cgacgaatcg
3259621 atgccggacg aggctcaact ggagttggca cgcacacgca cgctgctggt cgccagcgtg
3259681 gtcgagaccg tgacgcgaat gggtgcccgc aagagccccc gactgtggat cgtcacccgt
3259741 ggcgctgcac agttcgacgc aggcgagtcg gtcacgttgg cgcagaccgg cctacgtggc
3259801 atcgcacggg tgctgacatt tgagcattcg gagttgaata ccaccctcgt agatatcgaa
3259861 ccggacggca ccggctcgct ggccgccctg gccgaggagt tgcttgccgg ttccgaggcc
3259921 gacgaggtcg ccttgcgcga cggtcaacgc tatgtcaacc ggctggtgcc cgcacccacc
3259981 acgaccagtg gtgatctcgc cgccgaagct cgccaccagg tggtgaacct ggacagctcg
3260041 ggcgcttcca gggcagctgt ccgactgcag atcgatcaac ccggacggct ggacgcacta
3260101 aacgttcacg aggtgaaacg gggcagaccg caaggcgatc aagtcgaggt tcgcgtcgtc
3260161 gccgccggac tcaacttcag cgacgtgctc aaagcgatgg gcgtgtatcc gggactcgac
3260221 ggtgccgcgc cggtgatcgg cggcgaatgt gtcggctacg tgacggccat cggtgacgag
3260281 gttgacggcg tcgaggtcgg acagcgagtt atcgcattcg gccctggcac attcgggacc
3260341 catctgggga ccatcgccga tctcgtcgtc ccaattccgg acacgctagc cgacaacgag
3260401 gcggccacgt tcggcgtcgc ctatctcacc gcctggcact cgctgtgcga ggtcgggcgc
3260461 ctatcccccg gcgaacgcgt gctcatccat tccgccaccg gcggtgttgg aatggcggcg
3260521 gtctcgatcg cgaagatgat cggcgcccgc atctacacga cggccggttc ggacgccaaa
3260581 cgggaaatgc tttccaggct cggtgtcgag tacgtcggcg actcgcgaag cgtggatttc
3260641 gctgacgaga tcctcgagct gacagacggc tacggtgtgg acgtcgttct caattcgctg
3260701 gcgggcgagg cgattcaacg cggcgtgcag atccttgcgc ccggtggccg gttcatcgaa
3260761 ctgggcaaga aggacgtcta cgccgatgcc agcttgggct tggccgcgct agccaagagc
3260821 gcgtccttct ccgtggtcga cctcgacctg aatctcaagc tgcagccggc gcgctaccgc
3260881 caactcctgc aacacatcct gcagcacgtg gcggatggca aactcgaggt acttcccgtc
3260941 accgcattta gcctgcacga tgcggccgac gcattccggc ttatggcatc cggtaaacac
3261001 accggcaaga tcgtcatctc gataccccag cacggcagca tcgaggcgat cgctgccccg
3261061 ccaccacttc ctctggtcag ccgcgacggc ggctacctca tcgtcggcgg tatgggtggt
3261121 ctcggattcg tcgtcgcgcg ctggctggct gagcaaggtg cgggactgat tgtcctcaac
3261181 ggacgctcgg cccccagcga cgaggtggca gccgctatcg cggagctgaa cgcctccggt
3261241 agccggatcg aggtgatcac cggcgacatc accgagccag acaccgccga gcggctggtg
3261301 cgggcggtcg aagacgccgg gttccggctg gccggggtgg tgcacagcgc gatggttctc
3261361 gccgacgaga tcgtgttgaa catgaccgat tccgccgctc ggcgagtgtt cgccccgaag
3261421 gtcaccggca gctggcggct tcatgtggcc accgccgcgc gcgacgtcga ctggtggctg
3261481 accttctcct cggccgccgc gctgctgggc actcccgggc agggcgcgta cgccgccgcc
3261541 aactcgtggg tcgacggcct ggtcgcgcat cggcgctcgg ccggacttcc cgctgtcggg
3261601 atcaactggg gcccgtgggc cgacgttgga cgcgcgcagt tcttcaaaga cctcggggtg
3261661 gagatgatca acgccgagca ggggcttgcc gccatgcagg cggtactcac cgccgatcgc
3261721 gggcgcaccg gtgtgttcag cctcgacgcg cggcagtggt tccaatcgtt ccccgctgtg
3261781 gcggggtcct cgctgttcgc gaagctgcat gactcggcgg cccgcaaaag tgggcagcgg
3261841 cgcggcgggg gcgcgattcg cgctcagcta gacgccctcg acgcggccga acgcccaggc
3261901 cacctcgcgt ccgcgatcgc cgacgagatc cgtgcggtgc tgcgctcagg cgatcccatc
3261961 gatcaccacc gaccgctgga aaccctggga ctcgactcgc tgatgggcct ggaattgcgc
3262021 aatcggctgg aagcaagtct gggcatcacg ttgccggtcg cgttggtgtg ggcatacccg
3262081 acgatcagcg atctcgcgac cgccctgtgc gaacgaatgg actacgcgac acccgcggct
3262141 gcgcaggaga tttccgatac agaacccgaa ctgtccgacg aggagatgga tttgctcgcc
3262201 gatctggttg acgccagcga gctggaagct gcgacgcgag gcgagtcatg acaagtctgg
3262261 cggagcgcgc ggcgcaactg tcgccgaacg cgcgagcggc cctggcgcgc gagctcgtcc
3262321 gtgcgggtac gaccttcccg accgacatct gcgagccggt ggcggtggtg ggcatcggct
3262381 gtcgctttcc ggggaatgtg actgggccag agagcttttg gcagctactg gccgacggtg
3262441 tggacacaat cgagcaggtg ccgcctgatc ggtgggatgc ggacgcgttc tacgatcccg
3262501 atccttcggc gtcgggtcgg atgacgacga aatggggtgg tttcgtttcc gatgtcgacg
3262561 cgttcgacgc cgactttttc ggaatcactc ctcgggaagc cgtggcgatg gacccgcagc
3262621 atcggatgct gctcgaggtt gcctgggaag cgttggagca cgcgggtatt ccgccggatt
3262681 ccttgagcgg cactcgaacc ggcgtgatga tgggtctgtc gtcgtgggac tacacgatcg
3262741 tcaatatcga gcgcagagcc gacatcgacg cgtacctgag caccggaacc ccgcactgtg
3262801 ccgcggtggg gcggatcgcg tatctgttgg gattgcgtgg tccggccgtc gccgtagata
3262861 ccgcttgttc gtcgtcgctg gtggcaattc acttggcgtg tcagagcctt cgcctgcgtg
3262921 aaaccgacgt ggcattggcg ggcggggtgc agctcacctt gtcaccgttc accgccatcg
3262981 cgctgtccaa gtggtcggcg ctgtcaccga ccggccgatg caacagcttc gacgccaacg
3263041 cggatggatt cgtgcgcggc gagggctgcg gcgtggtggt gctcaagcgg ttggccgacg
3263101 cggtgcgcga ccaggaccgg gtgcttgcgg tggtccgcgg ttcggcaact aactccgatg
3263161 gtcggtccaa cggcatgacc gcaccgaacg cgctggcgca gcgtgacgtg atcacatccg
3263221 ccctcaagct tgcggatgtt acccctgaca gcgtgaacta tgtcgaaaca cacggcaccg
3263281 gaacggtgtt gggggacccc atcgagttcg agtcgctggc ggccacttat ggcctgggta
3263341 aaggccaggg cgagagcccg tgcgcattgg ggtcggtcaa gaccaacatc ggccacctgg
3263401 aggcggccgc cggtgtggct ggattcatca aggcggtgct ggcggtgcaa cgtgggcaca
3263461 ttccccgcaa cttgcacttc acccggtgga acccggccat cgacgcgtcg gcgacgcggc
3263521 tgttcgtgcc gaccgaaagc gccccgtggc cggcggctgc cggtccacgc agggctgcgg
3263581 tgtcatcgtt cggcctcagc gggaccaacg cgcacgtggt ggtcgagcag gcacccgaca
3263641 ccgcagtagc cgcagccggc ggcatgccgt atgtttcggc gctgaacgtc tccggcaaga
3263701 cggccgcgcg ggtggcgtcg gcggcggcgg tgctggccga ctggatgtcg gggccgggcg
3263761 cggcggcacc actggccgac gtggcacaca cgttgaaccg gcaccgggcc cggcacgcca
3263821 agttcgccac cgtcatcgcg cgtgaccgcg ccgaggcgat cgcggggttg cgagcgctgg
3263881 cggccggaca accacgcgtt ggggtggtgg attgcgacca gcatgccggt gggcctggcc
3263941 gggtttttgt gtattcgggt cagggctcgc agtgggcgtc gatgggccag cagttgctgg
3264001 ccaacgaacc ggcgttcgcc aaggcggtag ccgagctgga tccgatattc gttgaccagg
3264061 ttggcttttc gctgcagcaa acgcttatcg acggcgacga ggtggtgggc atcgaccgca
3264121 tccagccggt gctggtcggg atgcagttgg cgctgaccga gttatggcgg tcctatgggg
3264181 tgattccaga tgccgtgatc gggcactcga tgggtgaggt gtcggcggca gtggtggccg
3264241 gcgcgttgac gcccgagcag ggcttgcggg tcatcaccac ccggtcgcgg ttgatggcgc
3264301 ggctgtcggg gcagggagcg atggcgctgc tcgagctgga tgccgacgcc gccgaggcgc
3264361 tgattgccgg ctatccgcag gtgacgctgg cggtgcatgc gtcaccgcgc cagacggtga
3264421 tcgccgggcc gcccgagcag gtggacacgg tgatcgcggc ggtagcgacg caaaaccggt
3264481 tggcgcgccg cgtcgaagtc gacgtggcct cccatcaccc gatcatcgat cccatactgc
3264541 ccgagttgcg aagcgcgtta gcggatttga ctccgcagcc gccgagcatc ccgatcattt
3264601 ccactacgta cgaaagcgcg cagccggtgg cggatgccga ctattggtcg gccaacctgc
3264661 gcaacccggt gcgattccac caggccgtca ccgccgccgg tgtcgaccac aacaccttca
3264721 tcgaaatcag ccctcacccc gtgctcacgc acgcactcac cgacaccctg gatccggacg
3264781 gcagccatac agtcatgtcg acgatgaacc gcgaactgga ccagacgctg tatttccacg
3264841 cccaactcgc cgcggtcggt gtggctgcgt ccgagcacac caccggtcgc cttgtcgacc
3264901 tgccccccac accgtggcac catcagcgat tctgggtcac ggatcgttcg gcgatgtccg
3264961 agctggccgc gacccacccg ctcctgggcg cgcacatcga gatgccgcgc aacggagacc
3265021 atgtctggca gaccgatgtc ggcaccgagg tctgtccctg gttggcagac cacaaggtgt
3265081 tcggtcaacc catcatgccg gccgcggggt tcgccgagat cgccttggcg gcggccagcg
3265141 aagccctcgg cacagccgcc gacgccgtcg cacccaacat cgtgatcaac cagttcgagg
3265201 tggagcagat gctgcccctc gacggccaca cgccgctaac gacgcagtta attcgcggcg
3265261 gggacagcca gattcgggtc gagatctatt cccgcacgcg tggcggagag ttctgccgac
3265321 acgccacggc caaggttgaa caatcgccgc gcgaatgtgc gcacgcgcac ccggaagccc
3265381 aaggtcccgc caccgggaca acagtgtcgc cggccgattt ttatgccctg ctccgccaaa
3265441 ccggccaaca ccatggtccg gcgttcgcgg ccttaagccg gatcgtgcgc ctggccgatg
3265501 gttccgcgga aaccgagatc agcattcccg acgaggcgcc gcgccatccc gggtatcggc
3265561 tgcaccccgt ggtattggat gcggcattgc aaagcgtggg tgccgcgata cccgacggcg
3265621 agatcgcggg gtcggcggaa gccagctatc tgccagtgtc gttcgagacc atccgggtgt
3265681 accgcgacat cggtcggcac gtcaggtgtc gtgcccacct gacaaacctc gacggcggca
3265741 ccggaaagat gggcaggatc gtcctaatca acgacgccgg ccacatagcg gccgaagtgg
3265801 acggcatcta tctgcgtcgt gtcgaacgcc gtgcggtacc cctgccacta gagcagaaga
3265861 tcttcgatgc cgaatggacc gaaagcccga tcgcagccgt gccggctccg gagccagctg
3265921 ccgagacgac gcggggaagt tggctggtac tcgccgatgc aacggtggat gcgccaggca
3265981 aggcccaggc caagtcgatg gccgacgact tcgtgcagca gtggcgctca ccgatgcggc
3266041 gggtgcacac cgccgatatc cacgacgaat cggcggtgct ggccgcattt gcagaaacgg
3266101 caggcgatcc cgagcacccg ccggttggcg tggtggtgtt cgtcggcggt gcctcgagtc
3266161 gactggacga cgagctggcg gcggcgcgcg acacggtgtg gtcgatcacc acggtggttc
3266221 gtgcggtcgt cggcacgtgg cacggccgat caccgcggct atggctggtc accgggggcg
3266281 gactttccgt tgccgacgac gagccgggaa cacccgcggc ggcttccttg aaagggctgg
3266341 tgcgggtgct cgccttcgag cacccggaca tgcgcaccac cctggtcgat ctggacatca
3266401 cacaagaccc gctgaccgcg ctgagcgcgg aactgcggaa tgccgggagt gggtcgcgcc
3266461 atgatgacgt gatcgcgtgg cgcggcgagc gcaggttcgt cgaacggctg tcgcgcgcca
3266521 cgatcgatgt atccaaaggg catccggtgg tgcgccaggg agcgtcgtac gtcgtcaccg
3266581 gcggcctcgg cggtctcggc ctggtcgtcg ctcgttggct ggtggaccgc ggcgccggcc
3266641 gggtggtgct gggtggccgc agcgatccca ctgacgagca gtgcaacgtc ctggccgaac
3266701 tgcagacccg cgccgagatc gtggttgtcc gtggcgacgt ggcatcgccg ggggtggcag
3266761 aaaagctgat tgagacggcc cgacagtctg ggggccaatt gcgcggcgtc gtgcacgccg
3266821 ccgcggtcat cgaagacagc ctggtgttct ctatgagcag ggacaaccta gaacgggtgt
3266881 gggcacccaa ggccaccggt gcgctgcgca tgcacgaagc caccgctgac tgcgagctcg
3266941 actggtggct cggattctct tccgccgctt cgctattggg ttctcccggg caagcggcct
3267001 acgcgtgcgc cagcgcgtgg ctggacgcgc tggtcggatg gcgcagggca tccggcctgc
3267061 cggccgcggt gatcaactgg ggtccgtggt cggaggtagg cgtcgcccag gccttggtgg
3267121 gcagtgttct cgacacgatc agtgtcgcag aaggcatcga ggctctcgac tcattgcttg
3267181 ccgccgaccg gatccgcact ggagtggctc ggctgcgtgc cgatcgggcc ctggtcgcat
3267241 tcccggagat ccgcagcatc agctacttca cccaggtggt cgaggagctg gactcggcgg
3267301 gtgacctcgg cgactggggc gggcccgacg cgcttgccga cctcgacccg ggcgaggcgc
3267361 ggcgcgcggt gaccgagcgg atgtgtgcgc gcatcgctgc ggtgatgggc tacactgacc
3267421 agtcgactgt cgaacccgcc gtgcccttgg acaagcccct gaccgagctg gggctggatt
3267481 ctctgatggc ggtacgaata cgcaacggcg cgcgggcgga tttcggcgtg gaaccgccgg
3267541 tagcgctgat actgcaaggc gcgtccttgc atgacctgac ggcggactta atgcgccaac
3267601 tcgggctcaa tgatcccgat ccggcgctca acaacgctga cactattcgc gaccgggcgc
3267661 gccagcgcgc ggcagcgcga cacggagccg cgatgcggcg ccgacctaaa cctgaagtac
3267721 agggaggata agacctgtga gcatccccga gaacgcgatc gcggtggtcg gcatggccgg
3267781 ccgatttccg ggcgccaagg atgtttcggc gttctggagc aaccttcggc gcggtaagga
3267841 gtcgatcgtc accctgtccg aacaggagct gcgcgacgcc ggcgtcagcg acaagacgct
3267901 ggccgatccg gcgtatgtgc gtcgcgcccc gcttcttgac gggatcgacg agttcgacgc
3267961 cggcttcttc gggttcccgc cgctggccgc gcaggtgctg gatccccaac accggttgtt
3268021 cctgcagtgt gcatggcatg cgctcgagga cgcgggcgct gaccccgcac ggttcgacgg
3268081 ctcgatcggc gtatacggaa ccagctcccc cagcggctat ctgctgcaca acctgctgtc
3268141 gcatcgcgac ccgaacgctg tgttggccga gggactcaac ttcgaccagt tcagcctgtt
3268201 cttgcagaat gacaaggact ttctggcaac ccggatttcg cacgcgttca acctgcgcgg
3268261 gccgagcatc gcggtgcaaa ccgcgtgttc atcgtcgctg gtagcggtgc atctggcctg
3268321 cctgagcctg ctatccggcg aatgcgacat ggcgttggcc ggcgggtcgt cgctatgcat
3268381 cccgcaccgt gtcggctact tcacctcacc gggatcgatg gtgtcggcgg tgggccactg
3268441 tcggcccttc gacgtgcggg ccgacggcac ggtcttcggc agcggtgtcg ggttggtggt
3268501 gctcaagccg ctggcggccg ccatcgacgc cggagaccgg attcacgccg tcatccgcgg
3268561 atcggcgatc aacaacgacg gatcggcgaa gatggggtat gcggcgccca acccggccgc
3268621 tcaagccgat gtcatcgccg aagcccatgc ggtgtccggc atcgattcgt cgaccgtgag
3268681 ctatgtcgag tgccacggaa ccggcacccc gctcggtgat cctatcgaaa tccagggcct
3268741 gcgagcggcg ttcgaggtgt cgcagacgag ccgttcggcc ccttgtgttc tggggtcggt
3268801 caagtcgaac atcggccacc tggaagttgc tgccggcatc gcgggtctga tcaaaacgat
3268861 tctgtgccta aagaacaagg cactacccgc gacgctgcac tacaccagcc cgaacccgga
3268921 actgcgcttg gaccaaagtc cgttcgtcgt gcaaagcaag tacggcccct gggagtgcga
3268981 cggcgttcgt cgtgccgggg tgagttcgtt cggggtcggg ggtaccaacg cgcacgtcgt
3269041 cttggaggag gcgccagcag aagcatcgga ggtttcagcg cacgccgagc cggctggccc
3269101 tcaggtaatc ctgctctcgg cgcaaacggc cgcggcgctc ggcgagtcgc ggaccgccct
3269161 ggccgcggcg ctagaaacgc aagacggccc gcgcctgtcc gacgtggcct acacgctcgc
3269221 ccggcgccgc aagcacaacg tcacgatggc cgccgtcgtg cacgaccgcg agcacgcggc
3269281 caccgtgctg cgggcggccg agcacgacaa cgttttcgtt ggcgaagccg cccacgatgg
3269341 ggagcatggc gatcgcgccg acgccgcacc cacgtcggat cgcgtcgttt tcctgtttcc
3269401 cggacagggc gctcagcacg tcggaatggc aaaagggctc tatgacaccg agccggtctt
3269461 cgcccaacac ttcgacacct gcgccgccgg attccgcgac gagacaggca tcgacttgca
3269521 tgccgaagtg ttcgacggga ccgcaacaga tcttgagcgc attgaccgtt cgcaaccggc
3269581 attgttcacg gtggaatacg cgctcgcgaa gttggtcgac actttcggcg tgcgcgccgg
3269641 ggcgtacatc ggatacagca ccggcgaata catcgcggcc accctggccg gcgtattcga
3269701 cctgcagaca gcgatcaaaa cggtgtcgct gcgcgcccgc cttatgcatg agtcgccgcc
3269761 cggtgccatg gtcgcggtgg ctcttggccc cgatgacgtc acgcagtacc tgccaccgga
3269821 ggtcgagctg tccgcggtaa acgatcctgg taactgtgtg gtcgccgggc ccaaagacca
3269881 gatccgtgca ctgcgccaac gtcttaccga ggcagggatt cccgttcgcc gcgtccgggc
3269941 aacccacgcg ttccatacca gcgcgatgga tcccatgctg ggccaattcc aagaattcct
3270001 gtcccgtcaa cagctacgtc ctccgcgcac accgctgctg agcaacctca ccggtagctg
3270061 gatgtccgac cagcaagtag tcgatccggc cagctggacg cgtcaaatca gctcccccat
3270121 caggttcgcc gacgagctgg acgtggtgct ggcagctcca agtcgaatcc tggtcgaggt
3270181 tggtccgggc ggcagcctga ccggttcggc tatgcgccac ccgaagtggt cgaccacgca
3270241 ccgcaccgtt cggcttatgc gccacccact gcaagacgtc gacgaccgcg acacttttct
3270301 gcgcgcgctg ggcgaactct ggtctgccgg agtcgaggtc gactggacgc cgcggcgtcc
3270361 ggcggtgccg cacctcgttt ccctgccggg ttatccattt gcccgtcaac ggcattgggt
3270421 cgaacctaac cacacggttt gggcgcaggc tcccggcgca aacaacggct caccggccgg
3270481 cactgcggat ggttccacgg ccgccaccgt cgatgcagcc cgcaacggag agtcgcagac
3270541 cgaggttacg ctgcaacgca tctggtcaca gtgcctcggc gtcagctcgg tcgatcggaa
3270601 cgccaatttc ttcgacctcg gcggcgattc tttgatggcg atcagcatcg cgatggccgc
3270661 cgccaacgag ggtctgacca tcacgccgca ggatctctac gaatacccga ccctggcctc
3270721 gctgacggcc gccgtcgacg cgtcgttcgc gtccagcggg ttggcgaagc ccccggaggc
3270781 acaagcgaac ccggcggttc cacccaacgt cacgtacttc ctcgaccgcg gattgcgcga
3270841 caccggccgc tgtcgtgtcc cgctgatcct gcgcctggat cccaagatcg ggctaccgga
3270901 tattcgagcg gtgctgaccg cagtggtcaa ccaccacgac gcattgcgcc tgcacctggt
3270961 cggcaacgat gggatatggg agcagcacat cgcggcaccc gcagaattca ccgggctttc
3271021 caaccggtcg gtgcccaacg gcgtggctgc aggcagcccc gaggaacggg ccgcggtctt
3271081 gggcatcctg gccgaactcc ttgaggatca aacggatccg aacgcgccgc tggctgccgt
3271141 tcatatcgcc gccgcgcacg gcggtccgca ctatctgtgc cttgccatac atgcgatggt
3271201 caccgacgac tcatcgcgcc agatcctggc gaccgacatc gtcaccgcgt ttggacaacg
3271261 gctggcaggc gaggagatca cgctggaacc ggtcagcacg gggtggcggg aatggtcact
3271321 gcgttgcgcg gccctcgcga cgcatccggc ggcgctggac actcgctcgt actggatcga
3271381 gaattcgacc aaggcgactt tgtggctggc cgatgccctt cccaacgcgc ataccgccca
3271441 tccgccccgc gccgacgagc tcaccaagtt gtcgagcacg ctaagcgtcg agcagacatc
3271501 cgagctggac gacggccggc gcaggttccg ccggtcgatt cagacgatcc tgctggccgc
3271561 cctcggccgc acaatagctc agacggtagg tgagggtgtg gtcgccgtgg agctcgaagg
3271621 cgagggccgc tcggtgctgc ggccggatgt cgacctgcgc agaacggtcg gctggttcac
3271681 gacgtactac ccggtaccgc tggcatgcgc aacagggctg ggcgcgcttg cgcagctgga
3271741 cgcggtgcac aacactctta agtccgttcc gcactacgga attggatacg ggctgctgcg
3271801 ctacgtttac gccccgaccg gacgtgtcct gggcgctcag cgcacacccg acattcactt
3271861 ccggtatgcg ggcgtgatcc ccgagctacc gtccggcgat gctccagtac agttcgactc
3271921 ggacatgacg cttccggtgc gcgaaccgat cccagggatg ggccacgcca tcgaacttcg
3271981 ggtgtatcgg tttggtggct cactgcatct cgattggtgg tacgacaccc gccggatccc
3272041 ggcggcaacg gcagaagcgc tggagcggac cttcccgctg gccctcagcg cgctgatcca
3272101 ggaggccatc gcggccgagc acacagagca cgacgacagc gagatagtcg gggaacccga
3272161 ggcgggcgct ctggtggacc tgtcgagcat ggatgccggc tgaggaggat cggatgcgca
3272221 acgacgacat ggcggtggtg gttaacgggg ttcgcaagac ctacggcaag ggcaagattg
3272281 tggccctcga tgacgtgagt ttcaaggtgc gccgcggtga agtgatcggg ctgctgggcc
3272341 ccaacggggc cggcaagacg accatggtgg acatcttgtc gacgctgacc cgaccggatg
3272401 ccggctcggc gatcatcgct ggctacgatg ttgtttccga accggccggt gtacgccgct
3272461 cgatcatggt caccgggcag caggtggccg tcgacgacgc gctttccggt gagcagaacc
3272521 tggtgttgtt tggtcgtctg tggggactga gcaagtccgc ggcgcgcaaa cgcgccgccg
3272581 aactgctcga gcaattcagc ctcgtacatg ccggaaagag gcgggtgggc acctactccg
3272641 gcggaatgcg ccgacgaata gacatcgcgt gcggattggt ggtccaaccc caggtggcgt
3272701 tcttagacga gcccaccacc gggctcgatc ccaggagccg gcaagctatt tgggatctgg
3272761 tggccagctt caagaagctg ggcattgcca cgttgttgac cacgcagtat ctcgaggagg
3272821 cggatgcgct cagtgaccgc atcatcctga tcgatcacgg cataatcatc gccgaaggca
3272881 ccgcgaatga actcaagcac cgcgccggcg acaccttctg cgaaatagtg ccccgcgatc
3272941 tgaaggatct ggacgctatc gtcgcggcgc tcggttcgct gttgcccgag caccacaggg
3273001 cgatgctgac gcccgactca gaccgcatta cgatgccggc gcctgacggc atacgtatgc
3273061 tcgtcgaggc agcgcgccgg atcgacgagg cgaggatcga gctagccgat attgcgctgc
3273121 gccgaccgtc actcgatcac gtattcctgg ccatgacgac cgatcccacc gagtctctga
3273181 cccatctggt gtcggggtcc gcgcgatgag cggcccggcc atagatgcga gccccgccct
3273241 gaccttcaac cagtcaagcg cgagcattca gcagcgacgc ttatcgaccg ggcgacagat
3273301 gtgggtgctc tatcggcgtt tcgccgcgcc gagcctactc aacggtgaag tactcaccac
3273361 ggtgggcgcg ccgataattt tcatggtggg cttctatatc ccgttcgcca taccgtggaa
3273421 ccaatttgtg ggtggcgcca gctcgggcgt cgccagcaac ttagggcaat acatcacgcc
3273481 gttggtcaca ctgcaggcgg tctcgttcgc cgcgatcggg tcgggctttc gagccgcgac
3273541 cgattcgctg ctaggcgtca atcgtcggtt tcagtccatg ccgatggccc cgttgacgcc
3273601 actgcttgcc cgcgtgtggg tggctgtgga ccgatgcttc acgggtttgg tgatatcgct
3273661 agtttgcggc tacgtcatcg gattccgttt tcatcgcggg gccctctata tcgtcggttt
3273721 ttgcctactg gttatcgcga tcggggctgt gctgtcattc gccgctgacc tggttggcac
3273781 cgttaccagg aacccagacg cgatgctgcc gctgctgagc ttgcccattt tgatcttcgg
3273841 actgctgtcc attggtctca tgccgttaaa gctgtttccg cactggatcc atccatttgt
3273901 tcgcaaccag ccgatctccc agttcgtcgc ggcgctgcgg gcattggccg gagataccac
3273961 caagacagcc tcacaggtga gttggcctgt gatggctccg acgttgacgt ggttgttcgc
3274021 tttcgtggtg atcctggcgc tttcatccac cattgttttg gctaggcggc catgatcacg
3274081 acgacaagtc aggaaatcga gcttgcaccc acacgtttgc caggctcgca aaacgctgct
3274141 cggctgttcg ttgcgcagac ccttttgcag accaaccggt tgctaactcg atgggcacgt
3274201 gactatatca ccgttatcgg agcgatcgtg ttaccgattc tcttcatggt ggtgttgaac
3274261 attgtgctag gtaacctagc ttatgtcgta acccacgaca gcgggctcta cagcattgtt
3274321 ccgctgatcg cactcggcgc cgcgatcact gggtcaactt ttgtcgcgat cgacctgatg
3274381 cgcgagcgct ccttcggact gcttgcccga ctgtgggtgc tgcccgtgca ccgagcatcg
3274441 ggcctgatct ctcgaatcct ggcaaacgcg attcggactc tggtcaccac tttagtgatg
3274501 ctaggtactg gggtggtatt gggtttccgg tttcgacaag gcctgatccc gagcctcatg
3274561 tggattagtg tcccggtgat actgggcatc gcaatcgcgg ctatggtcac taccgtcgcg
3274621 ctttacacag cacaaaccgt tgttgtcgaa ggcgttgagc tggtgcaagc aatcgcgatc
3274681 ttcttctcca cgggtttggt gccgctcaac tcgtatccag gctggattca gccgttcgtc
3274741 gcccatcagc cggtgagcta cgccatcgcg gcgatgcgcg gttttgcaat gggtggtccg
3274801 gtcctctctc cgatgatcgg gatgctggtg tggaccgcgg gtatctgcgt cgtatgcgcc
3274861 gtacccttgg ccattggcta ccgacgggcc agcacgcatt gaccagcacc gctggcccgg
3274921 gatgccgtga cgagttggga gtgttgagat gtttcccgga tctgtgatcc gaaagctgtc
3274981 gcacagcgag gaagtcttcg cgcagtacga ggtttttact tccatgacaa tccagctgcg
3275041 cggtgttatc gatgtcgatg cgctgtcgga tgccttcgac gccctcttgg aaacccaccc
3275101 agtcctggcc agccaccttg agcaaagctc cgacggcggt tggaatctcg ttgccgacga
3275161 cctgctgcac tctggaatct gtgtcatcga cggcacggcc gccaccaacg ggtcaccgtc
3275221 gggaaacgcc gaactacggc tcgaccagag cgtgtcccta ttgcatctgc agctgatcct
3275281 ccgcgaagga ggagccgagc tgacgctata cctccatcac tgcatggccg atggtcatca
3275341 cggggccgtt ctcgtcgacg agctgttctc ccgctacacc gacgcggtca ctaccggtga
3275401 ccccggcccg ataaccccgc agcccacgcc gctgtcaatg gaggctgtgc tggcacagcg
3275461 gggtatcagg aagcaagggc tttcgggagc tgaacgtttt atgtcggtga tgtatgccta
3275521 tgagatccct gccaccgaga cgccggcggt cctcgcgcat cctgggctgc cccaagctgt
3275581 tccggtcacc cgactctggc tttccaagca gcagacatcg gacctcatgg cgttcggccg
3275641 cgagcatcgc ctcagcctta acgccgtggt cgcggcagcc atcctgctga ccgagtggca
3275701 gctgcgcaac accccgcacg tcccgattcc ctacgtttac cccgtcgacc tgcgatttgt
3275761 tctagctccc ccagtggccc cgacagaagc taccaatctc ctcggggcgg cgtcttacct
3275821 cgctgagatc gggccgaata ccgacatcgt ggatctggca agcgatatcg ttgccacact
3275881 tcgggctgac ttggccaatg gtgtgattca gcagtcgggg ctccacttcg gcacggcatt
3275941 cgaaggaact cctcccggcc taccaccact tgtcttctgc actgacgcca cttcatttcc
3276001 caccatgcgc acaccgccgg gcctggagat cgaagacatt aagggccaat tctattgttc
3276061 gatcagcgtc cccctcgatc tgtactcgtg tgccgtttac gcaggacaac tgatcatcga
3276121 gcatcatggg cacatcgcgg aaccggggaa gtccctcgag gcgatacgtt cactgctgtg
3276181 caccgttccc tcggagtatg gctggatcat ggagtgacct aacgaaccag cccgccgatc
3276241 gggcttcggc cagatcacgc actcgcgtcc cgaaccgatc atcatatccg ccccagctgc
3276301 ggtcgcggct gacaagcctt accccgcagc tcacctcatg atctcaccac gaggcttgcg
3276361 gcacaacaga attcgaccgc tatgatgccg ccggtgccgc cgcctgctcc tcggccagcg
3276421 tgtccgccaa gtactgggcc aaagcgcggg cggtgttgtt tgtggcgatg accttggggg
3276481 tcaggcgtat cccggtctcg gtttcaacgt gggtacgcat ctcgagcatg cccagcgaat
3276541 ccaggccgta ctcgatgaat gagcggtcag cgtcgatcgt gcgacgcagg atcacactgg
3276601 cctgctcaac cagcagacgc cgtagccggc cggcccattc atcttgcggc agcgaaagga
3276661 gctccatgcg gaatttgctt gggccccttg accgctgccc agtggatgcg aacatttcac
3276721 cccacgggct gcgtcggaca aggtcggcca gccatggcgc cccgaggatc ggaatgtaac
3276781 cgctgtaggc gcggtcgtgg cgcacgagcg tctcgaaggc atacgcacct tcctccgggg
3276841 tgatcatgat ttcgcccccc tcggccaaga acgtggcgcg gccgacctcg ccccacgcac
3276901 cccacgcaat cgcgctgacc ggcaggccct gggcgcggcg ccagtgcgcg aagacgtcga
3276961 cccagctgtt ggccgccgcg taggcgccct gacccggcga gccgagcaat gccgctcccg
3277021 aggagaacaa gcagaaccag tccagcggct gaccgagggt ggcgcggtgt aggttccagg
3277081 atccgaacac cttgggcgac cagtcgcgat cgatgagctc atcggtgatg ttggtcagcg
3277141 tggcatcctc gaccaccgcc gccgagtgca gcacaccgcg cagcggaagc ccggtagcgg
3277201 tcgccgcact caccagccgg tccgccgtgt cgggttcggc gatgttgcca cactccacca
3277261 cgatgtcggc cccagccgcg cgcaggcctt cgatggtctg ccgcgctttg gggttgggct
3277321 gggaacgtgc ggtcagcacg atccggccac agcccgccgc ggccagcttc gaggcgaaga
3277381 acaggccgag gccacccagg ccgccggtga tgatgtagga gccgtcgcgg cggtacagcg
3277441 gagcttgctc cggggtgacc gccacgcttc tacggccgct acgcggtacg tcgagcacga
3277501 gtttgccggt gtgctcggcg ttgctcattg cccggatggc gtcggccgcc tcggccaacg
3277561 ggtaatgagt gcattgcggt gcggtcagca ccccgtctgc ggtgagcttg aacaccgtgg
3277621 ccagcaactc acggacccgg tcgggctggg tgaccgacat cagcgcgagg tccaagtagt
3277681 agaaggtcag tccgcgacgg aacgggaaca gccccagccg ggtgttgccg taaacgtcgg
3277741 ccttgccgat ttcgacgaag cgtccgccga aggccaacaa ctccagcccc gcacgttggg
3277801 cggcgccggt cagcgagttc agcacgatat ccacgccgta cccgtcggtg tcgcgccgga
3277861 tctgctcggc gaactcgacg ctgcgcgaat cgtagacatg ctcgacgccc atgtcgcgca
3277921 gcatggctcg cttcgcggga ttgccggcgg tcgcgaaaat ctccgctccc ttggcgcggg
3277981 caatcgatat ggccgcctgc cccacaccgc cggtggcgga gtgaatcaac actttgtcac
3278041 cggccttgat ctgagccagg tcgttgagcc cataccaggc ggtggcatgc gcggtggccg
3278101 ccgtgatcgc ctgctcatcg gtcaagccgg gcggcagcgt gaccgcgagg ttggcgtcac
3278161 aggtgaggaa cgtccgccaa cagccacctt cggagaaacc gccaacacga tcaccgacct
3278221 ggtgaccggt gacaccttcc ccgaccgcag tcaccacacc gacgaaatcc atacccaact
3278281 gcggctcgcg gtcatcgata atggggaatc gtccaaacgc gatcaaaacg tcggcgaagt
3278341 tgatgctgga catgctgacc gcgacttcga tttgcccggg gccgggcgga actcggtcac
3278401 tcgcaacgaa ttccaacgtt tgcaagtctc ccggcctgcg gacctgcacc cgcataccgt
3278461 cgtggtcggg atccaagacc gcggtgcgcc gctcttcatg gcccagcgga ctgggggtca
3278521 agcgggccac ataccagtcg ccattccgcc aggccgtctc gtcctcttcc gatccgctca
3278581 gcagctgctg ggccacccgc tcaacgtccg tgtgttcgtc cacatcgatc aaggtggtgc
3278641 gcagcatcgg atgttcactg ctgatcaccc gtagcagacc acgcaggccg gcctgctcca
3278701 ggttggctct ttctcccgag tcgtgcggct tcactatctg ggcttgtctg gtcaccacga
3278761 acaagcgcgg cagctcgccc tcgaattcag ccagttcccg ggtgatccga accaggtgac
3278821 ggacctgttc acgaccggcc agcagactgt gctcatcggg gtcgccgacg cgaggcccat
3278881 acacgatcac cacaccatcg cggccacgca gctggctgcc cagcttttcg aggccagctt
3278941 gatcgttggg cggggtgtcc tggaccgacc aggacaggct ggcgcattcg gtgccttggg
3279001 ggccgtggga cttcagcgcg tccgtcaacg tggaagccaa catgtcgggg gtgtcgacgg
3279061 cgttggaagt gtcgatcaat agccacgatc cagcctcgcc gtcgccaacc tcgggcagcg
3279121 ctcgctgctg ccatccgagg gtcagtagcc gctcgctgac taggcggtca cgctcgtcgc
3279181 gttcggaggt cccggttccc atgcgtagcc cacgcacggc caacaggacg gtcccgtgct
3279241 cgtccagcac gtcgaggtcg gcctcaccac ctcgggtccc gtcgttgaag gccttggtca
3279301 accgcgtgta gcagtagcgg gcattgcggg taggcccgta ggcacgcagg ctgcgcacac
3279361 ccaacggcaa cagcaggcca ccagtggccg taccggcctg gacgcccgcg ccgaccgact
3279421 ggaaacaagc gtccagcagc gccgggtgga ttcggtaggc gccctgctgg aaccggatcg
3279481 acgcgggcag cgcgacctcg gccagcaccg tcgcggctcc cgcctcggcg gtatgcgcgg
3279541 tggtcagacc accgaacgcg gcgcccaaag taacaccacg ctcggcgaac gattcccgca
3279601 tggcggtccc gttcacggcg tgcggatgcg cctgcagcag agcggtgatg tcgtaccccg
3279661 gcggcgggca gtcatcttcg gcggcgcgca gcgccgcggt ggcatgccgg gtggtttcac
3279721 cgtcccggtt ggtctccacg gtgaagttga cgacaccagg cgcgtcgatc gatgcgacgg
3279781 cgtcgatcgg ggtctgctcg tcgagcaaca acatctgctc aaaggtgatg tcgcgaacct
3279841 cagccgcttc gccgaagacc tcagcggccg cagccaaagc catctcgcag taggcggcgc
3279901 cgggaagggc ggcaacgtta tgcacctgat gatcgctgag ccaggacagc accgaggtgc
3279961 caacgtcgcc ctgccagacg tggcgctcag gttcctcagt cagccgcaca tgcgagccaa
3280021 gcaacggatg cacggtgatg gtgcaggcac cttgtgcccg ctgttcttgc ccatcatcgt
3280081 cgatgaatag gcgggcgtgg gtccacgccg gcagcggcgc atccaccagc cgcccagcgg
3280141 gatacagcgc cgaatagtcc aaagcggcgc ccgcgcggtg cagctccgtc agcaagccgc
3280201 gcagaccatg cggcagaggc tgctctcgcc gcatgccggc cagggcggcg accgacatgt
3280261 cgaggcttcg gcccgtctgt tcgacggcgt gggtaagcag cgggtggggc gacagctccg
3280321 cgaagacccg gtagccgtcc tccatcgcag cctgcaccgc cgcggcgaac tgcaccgtgt
3280381 tgcgcagatt gtccacccag taagcgccat cgcacaccgg ctgctcgcgc gggtcgaaca
3280441 gggtcgccga gtagtacggc accttgggcg tcatcggagc aatgtccgcc agcgccgcgg
3280501 ccaaatcgtc gagtatcgga tcgacttgag gcgagtgcga cgccacgtcg acggccacct
3280561 cgcgcgccat cacgtcccgc tgctcccaac gggcgatgag gtcacgaacg gtgtcgctcg
3280621 taccgccgat caccgtggat tgcggggacg ccaccaccga gaccacaaca tcgtcgattc
3280681 cgcgtgccat cagctccgaa ttcacttgct tggcgggcaa ttccaccgag cccatggcac
3280741 cagcaccggc tatgcgggtc atcagcttcg agcggcggca aatgacgcgc gccgcgtcct
3280801 cgagcgacag tgcccccgcg acgacggccg cggccgactc acccatcgag tgtccgacga
3280861 ccgcgcccgg ccgcactccg taggtttgct ccatggtggc ggccaacgcg acctgaacgg
3280921 cgaacactgc cggctgcact ttgtcgattc cggtcacggt ctgctgcgcc gttatcgcct
3280981 cggtcaccga gaatcccgat tctgcggcga tcaccggctc cagcttggcg atggtggccg
3281041 cgaacactgg ttcgctggcg agcaattgcg tgcccatcgc cgcccactgc gacccttgcc
3281101 cggagaagac ccagaccggt cctcgatcac cgtgtcccac cgccgcgtca tagagggcgt
3281161 caccgtcggc cacctcgcgc aaaccctcga cgagctccgg caggttggcg gcaaccaccg
3281221 cggtgcgcac cggccggtgc gcgcggccac gcgccagcgt gtaggccaga tccgaggccg
3281281 ccacgcagtc ctggtgttct tccacccagg tggctagttg gcgggccgtc tggcgcagtg
3281341 cgtcgctgga cgtggacgac agcatgaata gccgcgggcc cacctcagcg tcgcccggtg
3281401 aactctcggg tgcggaagct tctgctgggg cctcttccac gatggcatgc acgttggtcc
3281461 cggacatccc gaacgaggac accgcgaccc gcttcggtgt gtgatcatta ccgttgggcc
3281521 acggcgtaac cgcttgcggc acaaagagcc cggtctcgac gtcggaaagc tcatcgggca
3281581 gccgattgaa atgcagcagc ggcggcacca ccccgtgccg cagtgacaga attgccttga
3281641 tcagcccgac ggtccccgcc gatgccgtgc tgtgccccat gttgctcttg gccgatccaa
3281701 gcgcgcaggg ggtgcccgcg ccatacaccc gcgccaggct gcggtactca atcgggtcgc
3281761 cgattggcgt accggtgccg tgcgcctcga ccacaccgac cgtttcgggc tgcacgcccg
3281821 ccgccgccaa cgccgcacgg tacacggcaa cctgggcgtc ctcggacggc atggtgagcg
3281881 tctccgtgcg gccgtcctga ttggtggccg tgccacgcac cacggcgaag atccgattac
3281941 cgtcgcgcag cgcatccggc agtcgcttca gcaacaccat cgcgcagccc tcggaacgca
3282001 caaacccatc cgcgtcagca tcgaatgaat ggcaccgacc ggttgacgac agcatgccct
3282061 gcgcagacgc cgccacactg gcatgcggct ccagcagcac cgcacaaccg cccgccaaag
3282121 cgaggtcagc ttcgccgtca tgcaggctgc ggcaggccag gtgcaccgcc atcagacccg
3282181 aagaacacgc ggtgtcaaac gtcatcgccg gaccatgtag acccaatgtg tgcgcgatcc
3282241 gccctgacgc cacactgttg ttgaggccgg taaccacata tggactggcc aaaccgcccg
3282301 ccgttgtggt gagtaccagg tagtcctcgt gggtcagccc agtaaaaacg gccgtcgagg
3282361 acccggccaa cgacgccgga tccagaccag catgctcgat cgcctcccac gacgtttcca
3282421 gcagtagccg ctgctgcgga tcgatcgagg tcgcttcccg ctcgctaatc ccgaagaact
3282481 cagcatcgaa accggcgacg tcgtcaagga acccacccca ccgggacacc gaccgcccgg
3282541 gaacccctgg ctcagggtcg taatagtcgt cggcgtccca gcggtcgggc ggaatctcgg
3282601 tgaccaagtc atcaccgcgc agcaacgact cccacagttt gtcgggcgag ttgatccccc
3282661 caggaagccg acatcccatc ccgatcaccg caacgggagt gacacgtgat tccatactct
3282721 tccaacctcg tctcagctca accggtgtta cccgacgaca tcagcgaatt ttcacaccgg
3282781 gaatgaaacg gccgcggtgc cgctctccca gctcttaagt aatccgagcc aacccggatc
3282841 ccgacaccaa agacaagtgt tacacgacgc caagaccccc cgcgggtagc gctggaatac
3282901 taacacgagc acatgtgctc gcgaccgagt ctcacctcgg acctgggcaa atgaccccat
3282961 gtcgcaggtg catggagttg ttcgggcagt ctcggcgagg ttgcagggct gttcgaccag
3283021 cggatttcga cactcggtaa cgcaagccag ttaggggcgg tcatcggtga tgctgcgcca
3283081 cgaagcacta catccgttgc accgcaatta ttttcggtgc ccgcatgacg ggcgcaatgc
3283141 cttaattgcg ttagccggcg acccgccgcg ggggcggcgc cacatcacat ccgaccgtgt
3283201 ccgatggtgg acccatggcg agccggcaaa cccctgctga gctggccaga tgcgacttgg
3283261 ctaagaccgc ggagcgcgag cacaccccga cggcgactgc gacaactcca agcgtggccg
3283321 gtaacgtgat gcccatgagt gtgcgttccc ttcccgctgc gttgcgcgcg tgtgcgcgtc
3283381 tgcaacccca tgacccggcc ttcacgttta tggattacga acaggactgg gacggcgttg
3283441 cgataaccct gacgtggtcg cagctgtatc ggcgaacgct gaatgtggca caggagctga
3283501 gccgttgtgg ttccacgggt gaccgcgtgg tgatctctgc tccgcaggga ctcgagtacg
3283561 tcgtcgcctt tctcggcgcg ttgcaggccg ggcgcatcgc cgtgccgctt tcggttccac
3283621 aaggcggcgt taccgatgaa cgttccgatt cggtactgag tgattcgtcg ccggtggcca
3283681 ttctcactac atcgtctgcc gtggacgacg tcgtgcaaca tgttgcgcgg cggcccgggg
3283741 aatccccgcc atcaattatc gaagttgatt tgctcgatct ggacgctccg aatgggtata
3283801 ccttcaaaga agacgagtat ccatctaccg cgtatttgca atacacctcc gggtccaccc
3283861 gcacgcccgc tggcgtggtg atgtcccatc agaacgttcg ggttaatttc gaacagctga
3283921 tgtctggcta ctttgcggat accgacggga ttccaccgcc aaattccgca ctcgtatcct
3283981 ggctaccctt ctaccacgac atgggtttgg taataggaat ttgcgcacca attctgggtg
3284041 gataccccgc ggtgctcacc agcccggtgt cgttcctgca gcgcccggcc cggtggatgc
3284101 acttgatggc cagcgatttt cacgcctttt cggcagcacc gaatttcgcc tttgaactag
3284161 cggcacgaag aacaaccgac gacgacatgg ccgggcgtga cctcggcaac atactgacca
3284221 tcctcagcgg tagcgagcgg gtacaggccg cgacgatcaa gcgcttcgcc gaccgctttg
3284281 ctcgcttcaa tctgcaggag agggtgatcc ggccttcata cgggctcgca gaagcaacgg
3284341 tgtacgtggc gacgagcaaa ccgggtcaac caccggagac cgtcgacttc gatactgaaa
3284401 gtttatccgc cggccatgcg aagccgtgcg caggcggcgg cgctacatcg ttgatcagct
3284461 acatgttgcc gcggtcaccg atcgtgcgga tcgtcgactc ggacacctgc atcgaatgtc
3284521 cggacggaac cgtcggcgag atctgggtgc acggcgacaa cgtcgctaat ggctattggc
3284581 aaaaacccga cgagagtgag cgcacgttcg gcggaaagat tgtcacccct tcgccgggca
3284641 cacccgaagg tccttggcta agaacgggcg actcaggttt cgtcaccgat ggcaaaatgt
3284701 tcatcatcgg tcggatcaaa gatctcctaa ttgtgtacgg acgcaaccac tcccccgacg
3284761 acatcgaggc aacgatccag gagatcaccc gcgggcgctg cgcggcgatc tcggttcccg
3284821 gtgaccgcag caccgaaaag ctggtcgcca ttatcgaact caagaagcgt ggcgactcag
3284881 atcaggacgc gatggctaga ctgggcgcta ttaaacgcga agtcacgtcg gctttatcga
3284941 gttcgcacgg tctcagcgtc gcggatctgg ttctggttgc gcctggctcg atccccatta
3285001 ccaccagcgg gaaggtcagg agaggggcgt gtgtcgagca atatcgacag gatcaattcg
3285061 cccgcttgga tgcctagtcc ggctggccgt ctacacagaa ttcggtatat ccgtttgaaa
3285121 aagtcctccc cggactgccg cgccaccatc accagcgggt cagccgacgg tcagcgaagg
3285181 tcaccccggc tcaccaacct gctcgtcgtc gccgcctggg ttgccgcggc ggtgatcgca
3285241 aatctgcttc tcacgttcac gcaagcagaa ccgcacgaca ccagcccggc gctgctgcca
3285301 caagatgcca agacagccgc cgccaccagc cggattgcgc aggctttccc cggcaccggt
3285361 agcaacgcta tcgcctatct cgtcgtggaa ggcggcagca cgcttgagcc gcaggaccag
3285421 ccttactacg acgccgccgt cggtgccctg cgcgccgaca cccgccacgt gggatccgtc
3285481 ctcgactggt ggtcagatcc cgtcaccgcc ccgctgggaa ccagccccga cggccgctcc
3285541 gctacggcca tggtgtggct gcggggcgag gcgggcacca cccaagctgc cgaatccctc
3285601 gatgccgtcc gatcggtgct gcgccagtta ccgcccagtg aggggcttcg cgccagcatc
3285661 gtggtcccgg caatcaccaa cgacatgccg atgcagataa ccgcctggca gagcgcgacg
3285721 atcgtgaccg ttgcggcggt gatcgccgtc ctactgctgc tgcgggcgcg cctgtcggtg
3285781 cgggccgcgg cgatcgtgct gctgaccgcg gacttgtcgc ttgcggtggc ctggccgctg
3285841 gccgcggtgg tgcggggaca cgattgggga accgattcgg tattttcttg gacgctggcc
3285901 gcggtcctga cgatcggaac catcaccgca gccaccatgc tggccgcgcg gctcgggtcc
3285961 gacgcaggtc attcggccgc gcccacatac cgcgacagcc tgcccgcgtt cgccctgccc
3286021 ggggcgtgtg tcgccatatt caccggcccg ctgctgctgg cccgaacccc agcgctgcac
3286081 ggagttggca ctgccgggct aggtgtcttt gtggcacttg cggcttcgtt gacggtgctg
3286141 cctgccctga tcgcgcttgc cggagcgtca cggcagttac cggcaccaac cacgggtgcc
3286201 ggctggacag gccggttgtc gctacccgtc tcttctgctt cggccctggg cacagcggca
3286261 gtgctggcga tctgcatgct acccatcatc gggatgcggt ggggtgtggc cgagaacccg
3286321 acaaggcaag gcggcgcaca agtccttccg gggaatgcgc ttcccgatgt ggtggtgatc
3286381 aaatccgctc gggacctgag ggacccagcc gcgctcatcg ccatcaacca ggtcagccac
3286441 cgtctggtgg aggttcccgg tgtgcgcaag gtggagtcgg cggcatggcc ggccggtgtc
3286501 ccgtggaccg acgcctcgct cagttccgcg gccggcaggc tcgccgacca gctgggtcag
3286561 caggccggat cgttcgtgcc ggcggtgact gcgatcaaat cgatgaagtc cataatcgaa
3286621 cagatgagcg gcgcggtcga ccaactggac agcaccgtga acgtgactct cgccggggca
3286681 aggcaagcac agcaatacct cgatcccatg ctcgccgccg cgcggaacct caaaaacaaa
3286741 accaccgaac tgtcggaata cctggaaacg atccacacct ggattgtcgg cttcacaaac
3286801 tgccccgacg acgtcctgtg cacggccatg cgcaaggtca ttgaacccta cgacatcgtg
3286861 gtcaccggca tgaacgagct gtccactggc gccgaccgca tctccgcgat atcgacacag
3286921 acaatgagcg cgttgtcctc ggcaccgcgg atggtggcgc agatgcggtc ggcgctagca
3286981 caggtgcgct cgttcgtacc caagctggaa acaaccatcc aggacgccat gccgcaaata
3287041 gcgcaggcgt cggcgatgct gaagaatctc agcgccgatt tcgccgatac cggtgagggc
3287101 ggcttccacc tgtccaggaa ggacctggcg gacccgtcgt accggcacgt acgggaatcg
3287161 atgttctcgt cagacggaac cgccacccgg ctgttcctct attctgacgg acaactggac
3287221 cttgctgcgg cagcacgcgc gcagcagctc gagatcgccg cgggcaaggc gatgaaatac
3287281 ggaagcctgg tcgacagcca ggtcacggtg ggtggggccg cgcaaatagc cgcggctgtc
3287341 cgcgatgccc tcatccacga tgctgtgcta ctggccgtta tcttgctcac ggtagtggct
3287401 ctggccagca tgtggcgcgg tgccgtccac ggtgctgcgg ttggcgtggg tgtgctggcc
3287461 tcttacctcg ccgccctggg ggtctcgatt gcactgtggc aacacctact ggatcgcgag
3287521 ctcaacgcct tggtcccgct ggtgtcgttc gccgtcctcg cttcgtgcgg cgtcccgtat
3287581 ctcgttgccg gcatcaaagc cggtcgtatc gccgacgagg caacgggtgc gcggtccaag
3287641 ggggcggtat ccgggcgggg agcggttgcg ccgcttgcgg cgctcggtgg cgtattcggc
3287701 gctggcctgg tgctggtgtc gggaggttcc ttcagcgtgc tcagtcagat tggcacggtt
3287761 gttgtgctcg gtctgggcgt gctgatcacg gtgcagcgag cgtggcttcc gaccacgcca
3287821 gggcggcgtt gaccgcctgt tcgagacccc atgccacgct cggctggccg acgacgatca
3287881 cccatcgcag acaccacact tggtaggggt tgccagttgt tggccgggtg agtggtcggc
3287941 gcgccgttgc ccggggtagg gttcgaggtc tttggatgat gggcgtttcc acgctgccca
3288001 aaggatgacc tcgacgtgtc cgagttcacg ttgaccgcgt gaagttaaac cggtgccgag
3288061 cgtgcactga gggcgaaatc cggcgccgat tttccgccct gagttcacgt tgggcgacgg
3288121 cgcccatgaa cgacgccaca tcgcacatgg cgctcaggcc aagcaccagc ccatctccgt
3288181 cgccggccac cgtcaccgat cgaacgacct cgacccccgc cctggcaaca acacgccgct
3288241 gccctctaca cctccgcgct gtcgaaaatt gtcacggagc cttgcggggg ctggtgcgac
3288301 tgatatgacg caccttccgc cagaggctag cccgacgttt actgacgtta ctgctgctta
3288361 ccgtttgtcg acggcacgtg aaaactgacc ccggcgcggc acccgaattt tgaccccctg
3288421 gtcgggtgga ctggctctac ccgagccagg aggaccgaag ggaatgttga ctgtggaaga
3288481 ttgggctgag attcgccgat tgcatcgcgc ggagggtttg ccgatcaaga tgatcgcccg
3288541 ggtgctgggg atttccaaga acacggtgaa gtcagcgttg gaatcaaacc agcagccgaa
3288601 atatgaacgg gcaccgcagg gttcgatcgt tgatgcggtt gagccgcgga tccgggagtt
3288661 gttgcaggcc tatccgacga tgccggcgac ggtgatcgcc gagcggatcg gctgggagcg
3288721 ctcgattcgg gtgctctcgg cgcgggtggc cgagctgcgc ccggtgtatc tgccgccgga
3288781 cccggcgtcg cgcaccacgt atgtggcagg cgaaattgcc cagtgcgact tctggtttcc
3288841 gccgatcgag ttgccggtag ggttcgggca gacccgcacg gccaaacagt tgccggtgct
3288901 gaccatggtg tgcgcctatt cgcgctggct gttggcgatg ctgctgccca gcaggtgtgc
3288961 cgaggacctg ttcgccggct ggtggcggct gatcgaggcg ttgggggcgg tgccgcgggt
3289021 gttggtgtgg gatggcgagg gcgcgatcgg gcgctggcgc ggcgggcggt cggagttgac
3289081 cactgagtgt caggcgttcc gcggcacgct ggcggccaag gtgctcatct gccggccggc
3289141 cgacccggag gccaagggcc tcattgaacg ggcccacgac tacctggagc gctcgttttt
3289201 gcccgggcgg gtgtttgcct cgccggccga tttcaacgcc caactgggcg cctggctggc
3289261 gctggtgaac acccgcaccc gccgggcgct gggttgtgcg cccaccgatc gcatcggcgc
3289321 ggatcgggcc gcgatgctga gcttgccgcc ggtggcgccg gccaccgggt ggtgcacctc
3289381 gctgcggctg ccccgggatc actatgtgcg ctgcgattcc aacgactact cggtgcaccc
3289441 gggtgtgatc gggcatcggg tgctggtgcg cgccgacctg gagcgggtgc atgtgttctg
3289501 cgacggtgag ctggtcgccg accacgagcg gatctgggcg gtccatcaga cggtctccga
3289561 tcccgcacat gtggaggcgg cgaaggtgtt gcgccgccgg cacttcagtg cagcatcacc
3289621 ggtagttgag ccgcaggtgc aggtccgctc actgagcgac tacgatgacg cgctgggagt
3289681 cgacatcgat ggcggggtgg cctgatgccc accaccaaag ccacccagcg ccgtgatgtt
3289741 tccaccgaga tcgcttacct gacaagagca ttgaaagctc ccaccctgcg tgagtcagtg
3289801 tcccggctgg ccgatcgcgc ccgcgccgag aactggagcc acgaagaata cctggccgcc
3289861 tgcctgcagc gggaagtgtc agcccgggag tcccatggtg gtgagggccg catccgcgcc
3289921 gcccgcttcc cggctcggaa gtcgttggaa gagttcgact ttgagcatgc tcgtggcctc
3289981 aaacgcgaca ccatcgcaca tctgggcacc ctggatttca tcaccgcccg cgataacgtc
3290041 gtgtttttgg gccccgcctg gcaccgggaa gactcatctt gcggtcggcc tggcgatacg
3290101 cgcgtgtcag gccggtcatc gggtgctgtt cgccaccgcc gccgaatggg tagcacggct
3290161 cgccgaggct caccacgccg ggcgcatcta cgccgaactc acccggcttt gccgctatcc
3290221 gctcctggtg gttgacgaag tcggctacat tccgtttgag cccgaggccg ccaacctctt
3290281 cttccagctg gtgtcctccc ggtatgagcg ggccagcttg atcgtcacgt ccaataaggc
3290341 cttcggccgg tggggcgagg ttttcggcgg cgacgacgtc gttgctgccg ccatgatcga
3290401 ccgcctcgtc caccatgctg aagtcgtcgc cctcaaaggc gacagctacc ggctcaaaga
3290461 ccgcgacctc ggccgcgtcc caccagccgg aaccaccgaa gaataaccac caaccgcccg
3290521 gtctaggggg tcaattttca gatgccgtca gggggtcagt tttcgggtgc cgttgacacc
3290581 gttcacaagg gcgtttcgag caacgcgtcg acgcaacttc ggcctagtcg acgttgacgg
3290641 gttcgttcca tttcgactgc gtgagctgaa tcgacccgga tccgaggtcg atgctcgctc
3290701 ggacgaggtg gtgcgagccg tcctgggcaa tccacacggt cgccggcctt gcactcttgg
3290761 cgccaggatc aagcatcttg acagagctcg cggggatggt cccggtgatt ttggtggtcg
3290821 aaattccgtc tatcacttcg gtaccttgcg cttggaggtt cgtgacaccg gacagcagct
3290881 gcgtcacccc agcggcagga tcgagcacgc gtgaagttga cagttcagaa atcgagccga
3290941 gattgctcca gtcgtcgaac agtttcaccg agatgttgtc gccttgtacc cgaaacggga
3291001 caccctgctc gtcgttgtag gtgcatacgc cctttgccgc gagcggattg gcccggacgt
3291061 cgacatcggc actggtaata cccagcaagc tgtcgacttt cccggttgtt cggaccgcta
3291121 cgtgcacgct ggtcaaccct tttgtcgcat caagcgactg cctgatctcg gcgaggagcg
3291181 cggggtcgga cgccgtcggg ctcacgggaa caccctgttc ctcggcatca ggtttcggcg
3291241 aagaacatcc tgatagccac aacgccaggc aggcacctag caccaccaga acagcggacg
3291301 tcaccgcccg ttttccatca ttcatttgcg ctcactacct cgattgtcaa atgggcccgc
3291361 aggccgaatg caggttgatt ggatcacgct gggcatgact gcccgcctcc tcactcgcgc
3291421 cattccggcg ctcgccgtcg ccgggccccg ccaaattgcc cgcctcctca ctcgcgccat
3291481 tccggcgctc gccgtcgccg ggctaggcat ggaccgatac ttccgcggcg gcgggttcga
3291541 caacctgcga cgtcggatca ccggattccg ttgggcggct gccagacatt tgctgggcga
3291601 catactcggc gaccgcagtg ggagtgggat gatcgaaaat cacggtaggt ggcagcgtca
3291661 gtccggtggc ggttttgagg cggttgcgta actccacagc cgttaatgag tcgaaaccga
3291721 ggtcgccgaa ttcggtgtcg gggtcgacgt cctcggcgga gggcctaccc agcactgccg
3291781 ctgcctgcag acacaccagc cccactagca gctcgagttg ttcgtccgcg gccagcccgt
3291841 gtaggcgttg agccagcgcc gacttcgacg aggtggcgtc accggtgtcg tcgatttggc
3291901 gtcggcgtgg gcggcgcgcg agcccgctga acagcgccgg caacgcaccg gcctgggccc
3291961 gggcgtctag tgcagcccgg tccaagagcg tggccaccgc cagagggtga tcgatggcca
3292021 gcgcagcgtc aaacaattcc accgcttcgg cagggctcat cggagccagc ccgctgcggc
3292081 tcatgcgggc cagatctcgg ctgctcaaat gcgcggtcat gccgccaggc tgttcccaca
3292141 aaccccacgc cagtgatatc ccggccaacc ctgcggcctg ccggtgagcg gccaacccgt
3292201 ccagaaacgc gtttgccgcc gagtagttgc cctgccccgg cgagccgacc gtggccgcga
3292261 tcgatgagca cagcgcaaac atcgacaaat ccaggtcact ggtggcctgg tgcaggttcc
3292321 acgccgcgtc caccttggcc cgcaacaccg tatcgatgcg gtccggtgtc aacgaggtga
3292381 tcactgcgtc atcgagcacg ccggcggcat gaatcacccc gcgcaccggc gggtactccc
3292441 gcgacagctg ggcaaacaac cccgctaccg cagcgcgatc ggccacgtca caggccacca
3292501 cctgcacctt ggcgccggcc tccgtcaagt cggcggccaa ttcggccgct ccctccgcgc
3292561 gatcgccccg ccgactggcc aacaccagat gacgcacccc ataggcgcca accaggtggc
3292621 gggccaacac cccaccaacc gccccggtgg caccggtgat caccaccgtg ccgtcggcaa
3292681 gccggtcggc caacgccgag ggcatggtta agacaacctt gccgatatgg cgggcctggc
3292741 tcatgaaccg gaaggccgcc ggggcgcagc gcacatccca cgtggtgacc ggtagccggt
3292801 gcagctcccg ggtgtcgaac agctcccgca cctcggccaa catctcctgc atgcgtgccg
3292861 ggccggcctc cgacaggtcg aacgcccgat actgcacgcc gggataatta gcggcgatct
3292921 cctgcgcatc gcggatatcc gtcttgccca tctcgaggaa acgcccaccg cggaccagta
3292981 agcgcagcga cgcatccacg aactcaccgg ccagcgagtc gagcaccaca tcaaccccgc
3293041 ggccctcggt gaccgccagg aacttctcct cgaactcgca tgtgcgggaa tcgccgatat
3293101 ggtcgtcgtc aaaccccatg gcgcgcagcg tgtcccactt gccacggctg gcggtgacga
3293161 aaacctccac gccccactgg cgagccagct gcacagccgc catgcccaca ccgccggtac
3293221 cggcatggat cagcaccgat tcgcccgcct tgatctcggc taaatcggcc aacccgtacc
3293281 aggccgtcaa gaacaccacc ggcacagcgg ctgcctgagc aaacgaccag ccttgcggca
3293341 cccgggtaac cagttgctga tccaccaccg ccagcggacc ggccccgccc aggaatccca
3293401 tcacggcgtc accgacggca agatcggtca cttcgggacc ggtctcaagc accaccccgg
3293461 cgccttcggc acccagcggt ggggcctggc cgggatacat ccctagggcg gccaccacat
3293521 cgcggaagtt gaccccgacg gccgccaccg ccacgcgcac ctgccccgcc tgtagcggtg
3293581 cctgtacctc cgggcagggc tggatcacca aatcctccag ggtcccgcca ccaccggcgg
3293641 ccaatcgcca cgccgactct gccgccggta acgctagcaa cgccggggcc ggggacagcc
3293701 ggggggcgtg cacagtgccg ccgcgcacca gcagctgggg ttccccgacg ccggctagca
3293761 ccgaggcatc caccgccgca tcggtgtcga tcaacacgat ccggccggga ttttcggcct
3293821 gcgcggaacg cgccatgccc cacaccgcgg cggcggccag gtcgctgatg tcctcgccag
3293881 ccagccccac gccaccatgg gtcaacacca ccaacgtggc cgcccgatcc gcgccgagcc
3293941 aggactgcaa cacctccagg gcggtgtggg tggccgcata caccgagccc accaccgagg
3294001 atgcttggcc accggcagac tcgagttccc acaccacgac actggcgtca ccatcactgc
3294061 cggcgcaaaa gtccgcccaa gacaccgggg caggtggggc ggacccgtta gcgccgccgc
3294121 tgaccaccga gatcggcgac cacaccactt ccagcggccc ctgatcggac gcaccgccgg
3294181 ccgcggtcac ggcggcgcgc agctgttctg cggttatcgg gcgagtaacc agcgagcgca
3294241 ccgtcaacac cggcagccca gtggcgtcgc agacgtccac ggaaatcgca tccgcgcccg
3294301 cggacgcgaa gcgggcccgc acccgtccag cgccgccggc atgcagcgac accccacgcc
3294361 agcaaaacgg cagtctcgtc tcggtgctcg cctgggtctt ctcgacggcc agcccgaggg
3294421 catgcagcac cgcgtccaac accgccggat gcatccccat tcggtcgacg gccacgccgg
3294481 cctcgccggg ggctacaact tcggcgaaca gctccgaccc ccgccgccag atcgccacca
3294541 gaccctgaaa cgcggggccg taggcataac cgcgctcggc caactgcgca tagccgtccg
3294601 agatatccac actctccgcg ccctcgggcg gccacacgga caaatccatc ggcgtctcag
3294661 cggcagccac ccccagcatg ccttcggcgt tcagcaacca accctgggat tgatcaccgc
3294721 gggaatacac cgacaccgca cggtgcccgg attcatcggc agccccgacg accacctgca
3294781 cctgaacccc gacacccggg tgcatcacca acggtgcggc cagcaccaac tcttcgatga
3294841 gcgcgcaccc gacctcatca ccggcgcgga tcaccaactc cacaaaaccc gccccgggga
3294901 acagcaccac cccgttcacc acgtggtcgg ccagccacgg ctgatccgca agcgacaacc
3294961 ggccggtcag caccacctcg tcagaatcgg gccgctcgac caccgcaccc aacaaggcat
3295021 gctcggtcgc gcccagaccc aacccggccg catcggcggg cccatccgcg cccggcgtct
3295081 cccaaaaccg ccgtcgctga aacgcatacg tgggcagctg cacccgccgt ccacccgagc
3295141 cggcgaacac cgccgaccac tgcaccggca caccggtggt gaacacctga ccggcagcac
3295201 cgagcgccga ggccagctcg ggccggtctt tgcccagcat cgacaccacc atcgcctcag
3295261 ccggggccaa ggactgctcg atcgagccag tcaaaccact tcccgggccg gcctcgatga
3295321 agtgggtcgc cccaagggtc tgcaaatgac gcgcactgtc cgcgaagcgc accggccgac
3295381 gaacgtggtc cacccagtac tgcgccgacc cgaaatcagg gccggccaac tcgcccgtca
3295441 cgttcgacac cagcccaagc tggggctcgc gtgcctgcac ccgggccgcg acacgcgcga
3295501 actcctcgag catcggctcc atcaacggcg aatgaaacgc atgcgagacc gccaactggt
3295561 gcacccgccg accctgcgcg gcgaaccgat ccgcaatcgc atttgccgcg gcctgcgcac
3295621 cggagatcac caccgattcg ggcgcgttga tcgcagcgat ccccacaccc tcacccagca
3295681 gcggctccac ctcgtcctca ctggcagcca ccgccaccat cgcaccgcct gccggcagcg
3295741 cctgcatcaa ccggccccgc gccaccacca gcatcgccgc gtccgccaac gtcaacacac
3295801 cggccgcgtg cgccgccgcc agctctccaa cggagtgacc catgacgaag tccggaagca
3295861 caccccaatc ccgcaacacc gcgaacgatg ccacctccac cgcgaacaac gcgggctgag
3295921 caaattcggt gctgtcaagc aaatccgcat cggcacccca aataacgtcg cgcagcggca
3295981 accgcagatg ccggtccaac tcgtcggcca ccgcatcgaa tgcctgcgca aacacgggca
3296041 actcgccgta caactcgcgg cccatcccga tgcgctgcgc gccctgccca ggaaacacga
3296101 ccaccgtctt gcccaccgac cctggctgac cgaccgccac gccggcaccc ggctcgcccg
3296161 ccgcgagccc agccagcccg gcaatcagtt gctcacggct tgcgccgacc accaccgctc
3296221 ggtgctcaaa caccgagcga ctggccaacg agcaccccac atcgatcgga tccagccctg
3296281 ggttggcctg cacgtgggcc ataagtcgac ccgcctgcgc cgtcaacgcc tcagccgatc
3296341 tcgccgaaat cacccacggc accatcgacg gccgcggccc ccggtgcttt cgctcgcctc
3296401 aaccggcgcc tctgcggggg ctggtacggg ggcctcttcc aagatcagat gcgcgttggt
3296461 gccgctgatc ccaaaggagg acaccgccgc ccggcgcgga cgcccgtcaa ccgaccactc
3296521 cctggcctcg gtcaacaccg acaccgcgcc gctggtccaa tccacccgcg gggaaggctc
3296581 atccacatgc aacgtcgccg gcatcacccc atgacgcatc gcctgcacca tcttgatcac
3296641 cccggcgacc cccgcggcgg cctgggtgtg gcccatgttc gacttgattg agcccaccca
3296701 cagcggctgc tccgctggac ctccctgccc gtaggtggac agcaatgcct gcgcttcgat
3296761 gggatcaccc aacgtggtgg cggtcccgtg tgcctccacc acgtctacgt ctgcggcgga
3296821 caacccggcg ttggccaacg ccacctggat cactcgctgc tgggcgagcc cattgggcgc
3296881 ggtcagccca ttggacgcac catcctggtt gaccgcgctc ccccgcacca ccgccagcac
3296941 cgaatgcccc aaccgccggg cgtccgatag ccgctccagc acaaccaccc cggcgccctc
3297001 gccccacccg gtgccgtcgg ccgcggccgc aaacgcctta catcgcccat cggcagccaa
3297061 cccccgctgc cgggaaaacc ccacaaaaat cgacggcagc cccatcaccg tcaccccacc
3297121 ggccaacgcc aaatcacact ccccggagcg caatgacgac atcgcccaat ggatcgccac
3297181 caacgacgac gaacaagcgg tatccactga caccgccggg ccctgcagcc ccaatacgta
3297241 cgacacacgt cccgaggcca cgctgattga cgtgccggtc aacccgtacc cttgcagccc
3297301 cccggtatcc ctattgccgt aactcgccgc gaaaatgccg gtgtacaccc cggtcgccga
3297361 accacgcaac gacaacgggt caatccccgc gtgctccaac gcctcccacg aaacctccag
3297421 catcaaccgc tgctgaggat ccatcgccaa cacttcacta ggagcgatgc cgaagaaccc
3297481 ggcgtcaaag ccggtggcgt cgtctagaaa tgccccccat cgcgtgtagg ttttgccctc
3297541 agcgtcggga tccggatcgt atagcccctc aacatcccag ccccgatcgg tcggaaactc
3297601 cgacaccacg tcgcgccccg ccgaaacgac atcccagagt ccgtccgggc catccacgcc
3297661 gcccggaaat cggcagccga ttcccaccac cgccaccggt tctgtcgcgc gttgctcata
3297721 ttcacgcagc cgagcgcgtg tctcatcgag ctcgacagca accttcttta ggtagtgaaa
3297781 aagcttttcg ctctgctggt cggcaccttc aacgctcatc gtccgttgct cctctatcac
3297841 ttcccaagtt cggaatcgat tagctggaaa atttcgtcag gagtcgaagc agcctggatc
3297901 agcttgccca ggcccgcctc gctgccggcg atggtgccca gcagggcacg caaacggtcg
3297961 gccacccgct gcttctcgcc gtcggcgatg acggccacca gctcttcgac cttgttcaac
3298021 tgctcttcga ttgcccaaag acccgtcgcg ccgctattca ccggaccggc tgatttcaat
3298081 cgaccatgcc cgccggccag ttcggcctcc aaatactggg ctaatcccga tatcgacccg
3298141 tagtcccacc caaccgtctc gggtaaccgc aggccggtaa ctgccgccaa tcgcttgcac
3298201 agcgtgactg tcatttgcga gtcaaaaccc agctccgaga aggcgagatc ctgatcgacc
3298261 gaccaaggat ctggctcacc taacatcttc gcggcctcgg cgcatacggc atccaccacc
3298321 agccgctgac gttcttgccg caaagcgacc aaccgctcgc gaagagtcgc cccgccgtcg
3298381 tttcctccgg cgatcgtcat gttggacgcc gacaggtcat cacgctgcgc ccgcacgccg
3298441 gacccaggtt cagtcaacga gagttcccaa atcggtttgg ttggactctg cttgcgcagg
3298501 gcgccacgca ccaatttccc gttcggggtt cgagggagtc gatcaacaac ggcaaaccta
3298561 tgcggcacct tgaacgcaga caatcggttg agcaatccgc ggtgaaggtc tcgcatgacc
3298621 gacccatcga tggtggcacc gctggtcgca accagaaaag cctgcagtgt cgacgcgccc
3298681 gtggactccc ttaccgcgac aaccgcggcc tcagccacgg cttcgtcctc gatgatgagt
3298741 cgctcgacct cacgcggatc aacgttgacc cctccgataa cctcggtgtc gtcggcgcgg
3298801 cagcggtagg taacccaccc gtcgctgtcg atacacaccc tgtcccgcgt gtcgagccaa
3298861 ccctcattcg cgacggggga atcaggccga ttccaatagc ccttagcgat cgccggtccg
3298921 cggacccata ggtcgccctc aaccccaggc ccggcagttg ttccatccgg cgctacaaca
3298981 cgaatctcgt agggcggcag cacccttccc agcgtcccca ggcgccattc gtcaacccga
3299041 ttcgatacga acgtctgccc gacctccgta gatccaatac cgtccagaat ggggatgccg
3299101 ccaaagaatt ccatgagccg ctcggcaaga cccagctcaa gggcctcccc ggctgacacc
3299161 acacatcgaa gcgaacggaa ggaatcagga gaacatgagt cgatgactct ggcaaagaaa
3299221 tttggcacac cgtagagcac cgatggccca aatcgcgcgc ttagaatggc cgctgcttct
3299281 ggagttaccg gcgccgaatt gatgaccgcg gaaccacctg tcgcgagtgg aaaccagacc
3299341 gaatttccta ggccgtaagc aaaatacatg cgtgcactac atagcccagt atcttcagga
3299401 gtgagccgca aggctttacg acacatagcg tccacgaacg tcaacgggtc ggcgtgccga
3299461 tgaatcgccg ccttcggcgg acccgtggta ccagacgtat acgtagcgta tgcgagtgcg
3299521 tcaccaccca tcggttcgta gcctccaggc gcgactcgag ccgcctcgga catgagttcc
3299581 gcggcttcgg ccacccgcga cggctgaaac cgatcgcgca gcgcatccga ggtgacgaca
3299641 agcgccggtt ccgtgttgcg tgcggccaac gcgtggtcgt cgcgatgcag ctccggattc
3299701 gctagaaacg ccataacccc acgagccagg cacgccagca atagctgcac caggtcgggc
3299761 gaatccggca ggcacaacag aacccgatca ccactggata gtccgcggtt tctcagcact
3299821 tccccaagac gtgcggcacc gtcgtggatt tgaccatgag tcaccacatc ggccgcatag
3299881 aaggccggcc ggtcgtacca tcccgcctcc gatgcctgct cagccaggag ccccgctaga
3299941 ttcccattcc gcatttattg gatgaccgcc ctagcgcgcc agagtgatgg catttgaaaa
3300001 ctgccagcga tcaggttctt catgcggagc atctcgaaat acgcttcgta gaaagtgctc
3300061 cgtcaccacc atgatcggct ggcctccgga aataacgcga taacggcggg caacggctct
3300121 ctttcgggaa ttctgatacc cgtggagcgc gagccaacct ggcaaatctc cgacccagac
3300181 tttagcctct tccttgaagg tctcgatgtg gctggctgcc ataacctcgc cgagaggatc
3300241 gtttgtctgc gtcaaccttg ttataattgc agccggcaac cgatcaatcg caatcaacga
3300301 ctccgcggct acaaataagt gttccgagtt ccgaccttta agtatgatgt accgctgcag
3300361 aacacggccg acccccacct gccctagctg ctcgaattcg gatagcttcg gtgaaacatc
3300421 gtgaatccgc tgcttgacga tttgcacgat cacctcatcg tcagcgacaa tgttgagaac
3300481 cctagtgagg gtgccattag ctgctatcag tattcgaagg tcacgattga gctttcggat
3300541 ctcttgatca gatagaaaac actcggtcat attcttcccc cacatacatg cgctgttatg
3300601 ccatagcatc taggcggctg aattcgtgat gtaggtaacg ctcaacgctg gccgaacgcc
3300661 gaaccttacc gctggtggtg accggaatag aacccggcgc caccataacg acatccgcga
3300721 cgcgcagacg atgtgacctg gatatcgcgg aggcgacttc acgtttgacg gtgcggagtc
3300781 gattcttttc ctcctcatct gtgcgacccc gcttcatgag ttcgataatg gttaccagct
3300841 tttcagtacg gtcatcgggc accgcaatcg ccacaacccg gccgccggtg atttcctgga
3300901 tcgtcgcctc gatgtcttcc ggatagtggt tggccccatc caccaccaac agctccttga
3300961 tgcgacccgt gatgaacagt tcgccctcga aaatgacgcc gaggtctccg gtccgcagcc
3301021 acggaccttc cgaagtcccg ggcgagggag tgacgagccg cgcgcggaac gtcgcctccg
3301081 tctgctgcgg gttgcgccag tagcccaagc cgacgttgtc tccctgcacc cagatttcgc
3301141 caaccgtccc cgcgggattc tccatcctgg tttcggggtc gacgatccgc acggttgacg
3301201 cccggggagc tccataactc accaggttgg ctccctcgct gccgttctcg gcacgcttcg
3301261 cctgaccgac cgacagctgc tggtagtcaa agcaaacact cttcggcgcg cgtcccggtc
3301321 cggcggtcgc cacgtacacc gtcgcctccg cgagcccata tgacggccgg attgccgtct
3301381 cgctgaggtt gaacggggcg aaccgctcgg tgaagcgccg cagcgtcgcg acgtttactc
3301441 gttcggcgcc ggtgacgatc gtccgcacat gcccgaggtc aagtccagcc atatcgtcgt
3301501 cggatgttct gcgtaccgcc aattcgaaac cgaaattcgg tgcgctggaa atctgtgcgc
3301561 ggtgtttggc taataattgc atccaacggg ccggccgctg caagaatgcc atgggactca
3301621 tcaacaccgc ggtgtcttga ttgatcatcg ggagaatgat gcccagcatc aaccccatgt
3301681 cgtgatagaa cggcagccac gatacgggag ttgacggaac cttttccgaa tccccgatgt
3301741 aatcggacat tagctgtacg cagttggtga tgacattctt gtgcgagagg acaacaccgg
3301801 ccggcgcgcg ggtcgaaccg gatgtgtact gtagatatgc tgtgctcgga cgctcgaacc
3301861 gagtcggatc gagcgctctg gatgagctca agtccagagc gtccacagcc acgacgatgg
3301921 gcgcggactg gccctgtgcg gcgcacgcat gtggcgcata tgtcgtgacc tcgtcaataa
3301981 ccgacgaggt cgtaagaata atggacggcg cagagtctcg taatgccgaa gatattcgtt
3302041 cgtcgtgaat gccgaattgt ggcaccggaa gaggaaccgc aatgagacca gcctgcagca
3302101 cacccataaa ggcgatgatg tattcaaggc cctgcggggc caatatcgcg acccgatcac
3302161 cgcttgacgc gtatatccag agctcctctg ccacgatcat cgctcgccgg tggacttgcc
3302221 accacgtcac ggtttcggtg aagccagccg gatccgtgtc atagtcaatg aacttgtacg
3302281 ccgcgcgatt ggggtactgg ctcgccgcct tctgtaggag atcagcgagc gacgactcgc
3302341 tcatagcgaa tcgcgatgtg ctcccgttca gcggttgtgc cgcttgctca ccggtgcccc
3302401 atgccggttg tgtcgccacc tcgcccgcgg catgaaatga cgagttggtt ttcatggtct
3302461 tccttcagct atggacggca gagagcagac ggctgcgctg ccgctttcat acgaatccga
3302521 gtcggcgcat agcgtctgta ccttgcccgg gctcgcgacg cgattcgtta aggtctcacg
3302581 accatagcag gtacgggcca cacccgaggg cctaatggga ttgacggaat cgtcagccgc
3302641 ggcgtcagcg ctggctgcag ccccattcgc gaaacacacc gtcgggctgg cttcgctaag
3302701 cctaatgagc accgtcttcg atgtcgacct gctgatcgtg ccggagcgaa ttcgccagcg
3302761 ccgtgcgatt cgttcgatcc ggtcgcgacg ggtggcaccc gcagagcgct gtcagacccc
3302821 acaggtcaca gttcagagac cgcaaccgac tgatcccgcc ggtacaccgt gcccccacca
3302881 acacgaatca cggcaagccc gttgcggcga ggccgaaccg agtaaccgct gatcaatggc
3302941 ctgacctcaa gtcagctgaa cgtgcgcacg gctgacctgt gggcactctg ggaaattcac
3303001 atcgagttcc aagctcgaca cgccgaaatc gcctgccgca cgccgcgatt ggcacgccag
3303061 ccgctgggcc ggcttacccc atcttcgcga gagtggcgca aatcatagct tcttgagccc
3303121 gcgcaaaacc ttggcgtgcg gcaggacagc cgtcaccgtc ttgcgcaggc tggggttaac
3303181 caaactgccg ttgatcagca caacgtagcg cagcccgtga tctcgccatt ccgctacttg
3303241 atcgatgact tcgtcagggg ttccactgaa gacgacttct ttcataagcg cagccgggac
3303301 cttggccgcg taggacaaaa ccgtctgttt gtccatggtt tgcgggatga tgtcctgcac
3303361 accggagaag tcggctccca ttggatgctc gacgccgtga cgcgcccagg cttccccagg
3303421 taccccgagc gcggtcatct tcacaacgac agattccagc gcctcttcca cgtcgtcgcg
3303481 attccgtcca gtgatgatgc cgcgcaccgc cgccggagta atcgacattg ggtcgcgtcc
3303541 ggcatcggac gccgcgctgc gcaccgcttc gagtgcgcga ctgtagtcgc tgggacgaac
3303601 cacaacaatg ggaatccagg catcggcgta acgtccggtg gcccgtaaca tccgcggccc
3303661 gtgggccgcg acccagattt cgggccattt cccacggtat ggcggaaggt cgaacaaggc
3303721 gttatgtaac ggaaagtatg gcgattcacg tgagataagc tccccgtttg aattccacaa
3303781 cgcgcgaatg gtggccaggg cttcttcgaa ccgcgccacc ggtttggtcc actccacacc
3303841 gtagggctcg ttgccttcac gttccccgac accgataccc aatatggctc ggcctcgggt
3303901 aagcaagtgc aaagtcgcgg cagcctgggc tgtgaccgct ggattgcgcc gacctgcatc
3303961 ggtcacgcac acgcccagtc gcagacggct gggcaacccg aaggcgaggt ttccaagcat
3304021 cgtccacggt tcgtaattgg catcgatctt gggcacgaat ttcgccgcaa ttccgagata
3304081 ttcggaagtc gcaatcgagc gcggcaccag cgcattcaga tggtcgccga cccaatacga
3304141 gtcggcgccc atcacggtgg cggccgccat gctagaccgt gccggcaggg tcggcggcaa
3304201 ccgcgagtgc acgagggcat caacaaaacc gaaacgaagt ccgcccacgc ctaccccttg
3304261 tctactacgc tgttgaccaa cgtcatggct aggaacgcta cctcagcgag tcatgtccgc
3304321 gcggtcgcgc gttgagcaac accggggtcg gatgtcatgg catcgaccgc gggctcggtg
3304381 ttgcgccaac ttctcttctg acgcatcgct cgtacatact gtctgccata ctccttgccc
3304441 atggccttca gtcgaaccca cagcctcctc gcccgcgcgg gcagtacctc gacctacaag
3304501 agagtttggc ggtactggta cccgttgatg acgcgcggac tcggtaacga cgaaatcgtg
3304561 ttcatcaact gggcctatga ggaagatccg ccgatggacc tgccactgga ggcatccgac
3304621 gagcccaacc gagcccacat caacctgtac caccgcaccg cgacccaggt cgatctgggc
3304681 ggcaagcagg tgctggaggt cagttgcgga cacggcggcg gagcctctta cctcacacgc
3304741 acgttgcacc cggcctccta caccggcctg gacttgaacc aggcgggaat caagttgtgc
3304801 aagaaacgac accggctgcc tggtttggac ttcgtgcgag gtgacgccga aaacctgccc
3304861 ttcgacgacg aatccttcga tgttgtgctc aatgtcgaag cctcgcactg ttacccgcac
3304921 tttcggcgtt tcctcgccga ggtggttcgc gtgctgcgcc caggagggta cttcccatac
3304981 gccgacctgc gccccaacaa tgagatcgcc gcatgggagg ccgacctcgc tgctaccccg
3305041 ctgcggcaac tgtcgcagcg gcaaatcaac gccgaagtgc tgcgcggcat cggaaacaat
3305101 tcacagaagt cacgggacct ggtcgaccgc catttgccgg ccttcctgcg tttcgcgggc
3305161 cgcgaattca tcggtgtgca gggcacgcag ctgtcccgct acctggaagg cggggaactc
3305221 tcgtaccgga tgtactgctt caccaaggac tgagccagtt tcgggtaatg tcgcccggat
3305281 gagcccagct gagcgcgagt tcgacatcgt tctatatggc gccaccggct tctccggcaa
3305341 gctgaccgcc gaacacctcg ctcacagcgg gtcaacagca cggatcgcat tggccggtcg
3305401 gtcaagcgaa cggctgcggg gcgtgcggat gatgttgggc ccgaacgcag cggactggcc
3305461 gctgatcctc gccgacgcat cccaaccctt gacgctcgag gcgatggccg cgcgggccca
3305521 ggtggtgctg accacggtcg gcccctacac gcgttacggc ctgccgctgg tggcggcctg
3305581 cgcgaaggcc ggaaccgact atgccgacct gactggcgag ttgatgttct gccgaaacag
3305641 catcgatctg taccacaaac aagccgccga cacgggcgcc cggataatcc tggcgtgcgg
3305701 attcgattcg atcccttcgg atttgaacgt gtatcagctg taccgtcggt ccgtcgagga
3305761 cggcaccggt gaactgtgtg acaccgacct cgtgctgcgt tcattctcgc aacgctgggt
3305821 ctccggcggc tcggtagcaa cgtattccga agcaatgcgc acggcatcca gcgaccccga
3305881 ggcccgtcgg ctcgtcaccg acccgtacac gctgaccacg gaccggggcg ccgaacccga
3305941 acttggtgcg cagccggatt ttcttcggcg tccaggacgt gatctggcgc ccgaacttgc
3306001 cggcttctgg accggcgggt ttgtgcaggc tccgtttaac actcgaatcg ttcggcgtag
3306061 caacgcatta caggagtggg cttatggccg gcggttccgc tactcggaaa caatgagtct
3306121 gggaaagtcg atggcggcgc cgattctcgc cgcagccgtc accggcactg tggcgggcac
3306181 catcgggttg gggaataagt atttcgaccg actaccccga cgattagtgg agcgcgtcac
3306241 gccaaagcca ggcaccggtc cgagccggaa aacgcaagag cggggccatt acaccttcga
3306301 gacgtacacc accacgacga ccggtgcccg ctacagggcg actttcgcgc acaacgtcga
3306361 cgcgtacaag tcgaccgcgg tgttgctcgc gcagagtggt ctggcgctgg cgctcgatcg
3306421 cgatcggctc gccgagctgc ggggggtgct cactcccgca gcggcgatgg gcgatgcgtt
3306481 gttggcgcgc ctcccgggcg ccggcgtggt catgggaacg accaggctga gctaacatct
3306541 ccaccccggc cgccagcaag attagctatg ccatgggcac attagcccaa tcctgttctc
3306601 ccagatctgg gcctttgccg ccgagaatca aactcctgac gacaacccac gttcacatgt
3306661 gggcttcagc accggcgctg caccatcgga agctcctcga ccagggtcgg caggttcagc
3306721 ggagcccgcg aagcgacaaa caccgcacga gccaaacctg tggaagctat cggtccgttc
3306781 gcccgccaat ccagtggaaa ctgccggtgc cggggctgcg tagcggtcac atatacgtgc
3306841 ggcatcttct ccctcagtcg gttcatcacc cacacgcgcg aaggccgaca ccccgtgccg
3306901 gttatcgcct ggctcggcga ggaagccctc tcactaacca gaaaaggctc gtcttcgccg
3306961 gaatagctca cgcatgtctc cagcagcaga aggtccactg cgcggtcaca catccacgcc
3307021 agcgcctcgg caggacggga gaggtggtag agcactccat agcagtacac cacgtcgtat
3307081 tggtgcgctt ctgctgggag atcgccgtcg agatctaggt ggtcgactgt gacattggga
3307141 ttggacccga agcgttggcg aatgacatcc agattctccc cccggggctc ggtgcagagc
3307201 accttgcacc cgcggtcgag gaagaactgc gtgtgatcgc cgatcccggc accaacctcc
3307261 agcacgctct tgttgccgag gtcgagcccc agcgtggcca ggtgctcctg acggcgggcg
3307321 ttgtgccgaa ggtaaaagat gctgtgaaaa tgccgttccg cagtcgggcg caacatgccg
3307381 gggagtcgca tcaggcgagg atagcgcacc tcgccgagga gaaacgctcg ccgatggcta
3307441 tcgagctgct gacacgtctg cggccccagc gtatcgacct cctcgagccc acgcccgctt
3307501 ggccctggac gccaccgcca cccagcagcg caaacgcccg gggcaagcac tcgaggtaga
3307561 gagcggcagc cggcgccagc tatcccttcc ggctcggaat aaagaagtag cagtaccggt
3307621 cgtcgcggtg ccgttggtag ggctgcagcc ccgcatcgtc ggcgtagacg aacggttcgt
3307681 aaccgtacgc gcggatgtcc gcaatggtcc gttccgggtc cggattagag gcggcgcccc
3307741 cgtagatctc caccagcagg accgggcgat cgcgccgcag aagctccgcg gcgcccgcga
3307801 tgaccgcgcg ctcgaggccc tcaacgtcga tcttcagcag acccaccggg aggggcagct
3307861 cggcggcgag cgcgtccagc gtggtacacg gcacccgtgt ccgctcgcga atccgaattc
3307921 gtcccgtgtc gtttagcgaa ctgaaggcgc tgtcggccgc cacgaaaaag tcgacctcgc
3307981 cgaccgcgtc cccggcggcc gtccgcagcg tgcggatgcg gtcttgcagg ccgttggcgg
3308041 ccacgttggc ctccaaccgc gaatgggtgc ccggcgccgg ctccagggct accaccgggg
3308101 ctaacctcgc ccaggccagg ctgtgtatgc cgacgttggc tccgacgtcg aggatgcagc
3308161 ggtctgggta gagcgcggaa tagagcgccg ccgcgatgtc gatctcggtc tcctcgaacc
3308221 cgccggtcaa ccgaacgatc cacgcgatgg ccgaccccgg ctcaagggtg acctggaggc
3308281 cgcgccaata ccagggggcc agccgccacc gatggggggg caagccaaac ggccgccagc
3308341 gttgcaggct tcgaacgagg cggtttggca tggcgcactc taacatccgg atcgcccgca
3308401 tccggtaggt cggccgttga gctccgaggt tctcgaaaca accagtggtg cccagatcca
3308461 aagggcgcca acgccgctgg cccttcgccg gcccaagccg tctgcacact accacccgca
3308521 tcaggcgcac atcttggaac tgcaccaggt ccaatcgtca gcagcgcctg gcgttgtgac
3308581 cgaacctcgg gtccgcagac ccactgcaat gttgcgcgac ccaaactatc ccccggggcg
3308641 gagtatttag cgtgttagtg ttgcacagtg aaatcgttga aactcgctcg tttcatcgcg
3308701 cgtagcgccg ccttcgaggt ttcgcgccgc tattctgagc gagacctgaa gcaccagttt
3308761 gtgaagcaac tcaaatcgcg tcgggtagat gtcgttttcg atgtcggcgc caactcagga
3308821 caatacgccg ccggcctccg ccgagcagca tataagggcc gcattgtctc gttcgaaccg
3308881 ctatccggac cgtttacgat cttggaaagc aaagcgtcaa cggatccact ttgggattgc
3308941 cggcagcatg cgttgggcga ttctgatgga acggttacga tcaatatcgc aggaaacgcc
3309001 ggtcagagca gttccgtctt gcccatgctg aaaagtcatc agaacgcttt tcccccggca
3309061 aactatgtcg gtacccaaga ggcgtccata catcgacttg attccgtggc gccagaattt
3309121 ctaggcatga acggtgtcgc ttttctcaag gtcgacgttc aaggctttga aaagcaggtg
3309181 ctcgccgggg gcaaatcaac catagatgac cattgcgtcg gcatgcaact cgaactgtcc
3309241 ttcctgccgt tgtacgaagg tggcatgctc attcctgaag ccctcgatct cgtgtattcc
3309301 ttgggcttca cgttgacggg attgctgcct tgtttcattg atgcaaataa tggtcgaatg
3309361 ttgcaggccg acggcatctt tttccgcgag gacgattgat tggaatcgct tcgcgaggcc
3309421 cggcaccaga ccgggcacca gaggtccgcg cagatcgcct gggtcgaaga tggtgcagac
3309481 gaaacgatac gccggcttga ccgcagctaa cacaaagaaa gtcgccatgg ccgcaccaat
3309541 gttttcgatc atcatcccca ccttgaacgt ggctgcggta ttgcctgcct gcctcgacag
3309601 catcgcccgt cagacctgcg gtgacttcga gctggtactg gtcgacggcg gctcgacgga
3309661 cgaaaccctc gacatcgcca acattttcgc ccccaacctc ggcgagcggt tgatcattca
3309721 tcgcgacacc gaccagggcg tctacgacgc catgaaccgc ggcgtggacc tggccaccgg
3309781 aacgtggttg ctctttctgg gcgcggacga cagcctgtac gaggctgaca ccctggcgcg
3309841 ggtggccgcc ttcattggcg aacacgagcc cagcgatctg gtatatggcg acgtgatcat
3309901 gcgctcaacc aatttccgct ggggtggcgc cttcgacctc gaccgtctgt tgttcaagcg
3309961 caacatctgc catcaggcga tcttctaccg ccgcggactc ttcggcacca tcggtcccta
3310021 caacctccgc taccgggtcc tggccgactg ggacttcaat attcgctgct tttccaaccc
3310081 agcgctcgtc acccgctaca tgcacgtggt cgttgcaagc tacaacgaat tcggcgggct
3310141 cagcaatacg atcgtcgaca aggagttttt gaagcggctg ccgatgtcca cgagactcgg
3310201 cataaggctg gtcatagttc tggtgcgcag gtggccaaag gtgatcagca gggccatggt
3310261 aatgcgcacc gtcatttctt ggcggcgccg acgttagcgc gataccaccg caacgttgac
3310321 tcgatgccct tgggcggcgt gatcttgggt ggccaacccg cctcttgcaa gaccgacacg
3310381 tctaacagct tgcgtggtgc ggcgcctgtc aagctctttg cgccagtgtc tcattatgtg
3310441 gacgctattt cggatctggg gtgggcgggt tgatccatgc cgcggtcgcc ggtttcgggg
3310501 gttgcggtga gacgccgaat ggattcgggt tggccgagta ggcgttggcc atggccgcgc
3310561 ccatgtggcc tggccaggtg cgggcgtgtt cgatcgaatc gaaccgttca ggagagtcgt
3310621 tgcggtactt cagcgttttg aactgcgaca cgctcccgaa tcaggtgctc gaccggacat
3310681 ccgttggcta gccggcgata tcgtgggcac cctttagcag acgagccgca gcgcactttc
3310741 gatgtgctgc gggaatccgg caaagtctgg tccgaaggct tcggcaagcc gccgggcggc
3310801 ttgtcggaac tcggccccac tgagcacctg ctttacggct gccgccacgc cttcagtgtt
3310861 gagccgctcg gttcgcagga gaacgccggc gccggcccgc tcaagggcct ccatgttcaa
3310921 gtgctggtcc atgttgctgg ggagcccgat caccggcacc ccggccgcca acgcctgctg
3310981 cgtcgtcggg ctgccgccgt tgcagagcac cacggcggag cgcgctgcag ccgcttcgcc
3311041 cggcaggtag tccgcgacga aggcgttggc cggcacgttc ttcaggtggt tccggccagc
3311101 ggtggccgcg atcaccgtga cgggtaaatc ggccagggcg ttcaaaacca cctgcaacag
3311161 gttctttccg ccggaactgc cgagggtcgc ataaataatc ggccggtctg tcggcagcga
3311221 gtgccaccaa gtcggcggtt ttacgtcggg cgaccacagg acgggtccga gatatcgatg
3311281 gttggccggc aggttgtatg tcggcaccag ctcgggtacg tcggcataca gggtgtagtc
3311341 accgtcggtg aaaatgcggc acaaatccca gcccagactc gacagcccgt gcttccggcg
3311401 gagccagttg agcgggagac aatagagggc aaagatcaac ggacggtaca ggcggtacag
3311461 gatgctgacc ggcctgaccc cgaagaagcg ggtccacggc acgtctggca gcggaaaccg
3311521 acggcgggcc tgaggactcc agtaggcgtt cgcgatggcg atgtacggaa tgccggctag
3311581 tcgggcgctg accgagagcg aaagacggtt gtcaccgacg actacgtccg gtgcgatctc
3311641 gttcaggatc ttcctgtcag ccgcgatgta tttgcgcaac gtccgcgtgt tgtagaagag
3311701 gcggccctga gcgattttaa ggagaacctc ctcgctgggg acggtgtgaa tcgggtgatg
3311761 tgggaacggg agcgggccca aaagcttatt gaaccgcggg tcgcaggcaa agtggacctc
3311821 ataacgactc gggtccagcg accgcgccaa cacgaacggc cggacgacgt gggccagggt
3311881 cgcggcctcc cctacaaaca ggatccgttg cctgcgagcg acaggctccg gtgcggcgtt
3311941 gggcgccgtg ctcgtcccag cgtccggtcc cgggtcgccg gcgacgcttg tttcctccat
3312001 actcgccccc taatctcgag gcagcccgta cccgcaggca acctcccaaa aatgcaatcc
3312061 cccaaaatgc aatgcgtcga gctatttctc acaccgaccg ctagttgcgg atcagaaatc
3312121 cgttgggcgc ggaagtccag ccgaatttgt tctcccgctc cgcatcatgc ttgtaatcgt
3312181 ttggaaattc atcctcatat gcctcgatcg cttcataggg tccaggccca aacccgggca
3312241 ggactgggtg gccgttgatg ttggaatcct cgactactag gtagtcaccg gcggagagta
3312301 gcggccgtag taatttcatc tcggccagca catgattcat cgagtggtcg ctatctaaga
3312361 tggcgaagat cttgccaggg tattcgtttt tgaggcgttg aatttgttcg gcaatcgccg
3312421 ggtcggtgga tgacgattca acgaacaaaa catctggttc gcgccgggct cttggatcga
3312481 gggctttgtg tgagttgtcc acggtaagta ccttgaatgg ctggccgatc tgcctcatga
3312541 tgttggcaaa atacaccgcc gagccgccgt agcgggtgcc gaactcgatg acgagggatg
3312601 gttgcaactc gctcaggatc tcctggtaat tccacatatc gctgacggat ttccagcaat
3312661 tgatccccat ataagtggtc ttcgtccaca ctaagttgcc gtagtaccac ttgtggtatt
3312721 cttccgccac tgcgtcgctc ggccggtaga ataactgggc cgcaaaactc gccactaacc
3312781 tgactagtcc gatcagttgc cctacaagac tagtccgact gcgccacact agccccattc
3312841 catcatctcc tcactgcgaa accgtagtca gtcgaatgtt ggtcatttag caagcctctt
3312901 taagagaact gatgaggtcg aagcggactc aatacatggc tgcggcaatt cgttagaccg
3312961 cgttcgcgcc cacgttgtga gctccgcgcg ccgcatcctt ggggctcggt gccgggcata
3313021 cgcgacccag cttgcggctg agcatcttct ggacaccgcc accgcacggc ggatggtagc
3313081 aacagattgg ggttaccctc aaaccgcggg ttatggactg ccaaaggtag ccagcttgtc
3313141 ctgctcgcgg tgacagcgca accacgggta gtgacactac cgccgtggcg ttcctcccca
3313201 cggcagaagg ccggggccgg tcgagttcgg gcacaagccc cagatcgtcg acaacgacga
3313261 tggcatcgtc ctggatcaca ccgtggagca cggcaatccg catgacgcgc cgcagctagc
3313321 gcccgcggtc gaacggatca ccacacgcgc cggacgcccg cccggcaccg tcaccgccga
3313381 ccgcggctac ggcgagaaac gcgtcgaaga tgacctgcac gacctcggtg tacgtacggt
3313441 cgcgataccg cgtaaaggca gaccctccca ggcccggcgc gccgaagaac aacggccatc
3313501 gttccgacga acagtcaagt ggcgcaccgg cagcgaaggc cgcatcagca ccctcaaacg
3313561 aaactacggt tggaaccgct cctgcatcga cggcaccgaa ggaacccgga tctggaccag
3313621 gcacggcatc ctcacccaca acctcatcaa gatcagcagc ctcgcagcat gacccggctc
3313681 ccagagcacg aagctctgcc ccaccaacag tccggcggca ttcgcccaca aacgactcac
3313741 ttagtcgccg tcactttttc aggtcgaagt aactagctgg ccaaccatgt ccggggccgg
3313801 ttctccggca tgaggcgcag agcattctcc acatgctgcg ggaatccaac gcggtctcgt
3313861 ccgaaggcat cggcgagtcg cgcggcggct tgtcggtact cggaccgact gatcacctgc
3313921 atcacggccc ctgccacccg ctgactcttc agccgctcag ttcgcagcag cacgcccgcc
3313981 ccggcccgct caacggcctc catattcaag tgctgatcga gattgcccgc gaccccgatc
3314041 accggcaccc cggccaccaa ggcctgctgg gtcgtcaaac tcccgccatt gcagaccacc
3314101 acggccgagc gagccgcagc ggcctcaccc ggcaggtagt ccgccacgaa ggcgttggcc
3314161 ggcacggtct tcaggtcact gcggcccgcg gtggccgcga tcaccgtcac cggcaactca
3314221 gccaacgcgt tcaacaccag ttgcaacaga tttctcccgc cggacgtgcc cagggttgcg
3314281 tacacgatcg gccggtcggt tggcagcgaa tcccaccatg tcggcggctt cccggcgggc
3314341 gaccacagga ccgggccaag gtactcgtgg ttggccggca agtcgtaggt gggcatcagc
3314401 tcgggcacgt cagcatacag ggtgtggtcc ccgtcggtga aaatgcggca caggttccac
3314461 cccagactcg acagcccgtg cctgcggcgg acccagttga gcggcatgca ctgcagggcg
3314521 aagagcaaag ggcgttccag gcggtagagg agcttgacca acctgacgcc gaacaagcgg
3314581 gtccatatca cgtcgggcag cggaaaacgc cgctgcgcgt acggactcca gtaggcattc
3314641 gcgatcgcga tgtaaggaat gccggccagt cgggcgctga ccgacagtga aatgcgaagg
3314701 tcaccgacga cgaggtccgg cgcgatctca tccaggaccc gcaggtccgc ctcaacgtac
3314761 ttccgcagcg tccgcatggc atagaaacga ccctgagtca gattgccgaa aaaccgctcg
3314821 ctggggatgg tgtgaatcgc atggtgacgg aaagggagcg gacctagaag ctggttgtag
3314881 cgcgggtcgc aggcgaagtg cacttcataa cgactagggt ccagcgactg cgcaagcgcg
3314941 aatggccgga cgacgtgagc cagggtcact gcttccgcga cgaaaaggat ccggcgcctg
3315001 cgtgcggcaa gcccaggtgc ggcgtccggt gtcgtgctga tggccgcgtc ccctctcacc
3315061 tcgctagcaa ccggtggccc gccccacctc gacgccgtag cgtacacgca cgacacgcgc
3315121 actcggggaa aacctcggca agagtggggc ggcgatacgt ttagcggcac cactgcgcgg
3315181 tcgttgccca ccccggtgac tatacccccg ggtggtatat ggtggagggc agagcgtgac
3315241 ctcaaccaaa gtggaggacc gagtgacggc agcagtgctg ggagcgatcg ggcacgcact
3315301 ggcgctgacc gcgtcgatga cctgggaaat cctgtgggcg ctgatcctgg gcttcgcgct
3315361 gtcggcggtg gttcaagccg tggtgcgccg ctccacgatc gtcacgctgc tcggcgacga
3315421 tcggccgcgc accctggtaa tcgccaccgg cctgggcgcg gcctcgtcgt cgtgctcgta
3315481 tgccgcggtg gctttggctc ggtcactatt ccgcaaaggg gccaacttca ctgccgctat
3315541 ggcgttcgag atcggttcca ccaacctcgt ggtggagttg ggcatcatcc tggccctgct
3315601 gatgggctgg cagttcaccg ccgccgagtt cgttggcggt ccaataatga tccttgtcct
3315661 ggccgtgttg ttccggttgt tcgtcggcgc ccggctcatc gacgccgccc gggaacaggc
3315721 cgaacgggga ctcgcaggct cgatggaagg ccatgccgcc atggacatgt ccatcaagcg
3315781 ggaaggctca ttttggcgac gactcctttc cccaccggga tttacctcca tcgcccatgt
3315841 gttcgtgatg gagtggttgg cgatcctgcg cgacctcatt ctcgggctgc tgatcgccgg
3315901 tgctatcgcg gcatgggtac ccgaatcgtt ctggcagagc ttctttttag ccaatcatcc
3315961 ggcctggtcg gcggtctggg gtccgatcat aggacccatc gtggccatcg tttcgtttgt
3316021 ttgctcgatc ggcaacgtgc cacttgccgc ggtgctgtgg aacggaggca tcagcttcgg
3316081 cggggtcatc gcgttcatct tcgccgacct actgatactg ccgatcctga atatctaccg
3316141 taaatactat ggcgccagga tgatgctggt gctgctcggc accttctacg catcgatggt
3316201 cgtcgctggc tatctcatcg aacttctctt cggtacaacg aatctcatcc cgagccagcg
3316261 cagcgctacg gtcatgaccg cagaaatatc gtggaactac accacctggc tcaacgtcat
3316321 ctttctggtg atcgcggcgg ccttggtggt ccgattcatc acatcgggcg gtctcccgat
3316381 gctacgcatg atgggcggct caccggatgc cccgcatgac caccatgacc gccacgacga
3316441 tcacctcggc cactagcgcc accacgccga tcagtcggcg ccgaaaaggc caccggcggc
3316501 ggtatcctgg cctgcgggta ttccacccat gggcaaaggg agcatgaccg cgcacgcaac
3316561 gccgaacgag ccggattatc cgccaccgcc tggcggtcca ccgccgccgg ccgatattgg
3316621 ccggttactg cttcggtgcc acgaccgccc tggaatcatc gccgcggtga gcaccttcct
3316681 ggcccgggcc ggcgccaaca tcatttctct ggaccagcac tccaccgcgc cggagggcgg
3316741 aacgttcttg cagcgcgcaa tctttcacct gcccggtctc acggccgccg tcgacgaact
3316801 gcagcgcgac ttcggcagca ctgtggcgga caagttcggc atcgactacc gatttgccga
3316861 agcagccaag cctaagcggg tcgcaatcat ggcatcgaca gaggaccact gcttgctgga
3316921 cttgttgtgg cgcaaccgtc gcggcgagct agaaatgtcg gttgtcatgg tgattgccaa
3316981 tcatcctgac ctggccgcgc acgtacgccc gttcggtgtg ccattcatac atattcccgc
3317041 cactcgcgac actcgtacgg aagccgaaca gcgtcagctt cagttgctaa gcggcaatgt
3317101 ggatttagta gtgctggcac gctacatgca gatactcagc ccggggttct tggaggcgat
3317161 cggctgcccg ctgatcaaca ttcaccattc gttccttcca gccttcaccg gcgcggcccc
3317221 gtaccagcgc gcacgagaac gcggcgtcaa actgatcggc gcgaccgccc actacgtgac
3317281 cgaagttctc gacgaggggc ccatcatcga acaagacgtc gttcgtgtcg accacaccca
3317341 caccgtcgat gatctggtgc gtgtcggcgc cgacgtcgaa cgcgcagtgc tttcccgcgc
3317401 cgtgctctgg cactgccaag accgcgtcat cgtgcatcac aaccagacca tcgtcttctg
3317461 acatgggtga ctgcgcgcgt tgcggtcaac ttcttggtgc ccatgatggt cacggcgtcg
3317521 actggccgtt tcggcgccgt cgcccagcgt gaactgaggg cggaaaatcg gctggcccga
3317581 atctcgcccc cagtgcacgc tcggcgccgt ttggcctcac ccggtcaacg tgaactgtcc
3317641 gggtgggcgc tgtcacgtag cgagcccacg tggggccggg gtcggcccgc caaaaacgcc
3317701 ccggcgcggc cagctcatga gcgagtacgc aagctcaagg gacacccgct ttgcactgtg
3317761 gaagaacccc gaagacctgg cctgcggcag gtgcggtcaa aggagcggag tgtagacagg
3317821 accggtgggt ctgctcagcg cggccccgaa ttaggacaat tttcgcacct agcgcatcca
3317881 atatcgcttt cgaagaacgt tcacgccagt cccactgggc cggtgcgaat ggtgcaacgc
3317941 gcctttcgtc gaaggaaacg ccgtccgcca ccgagcccgc gctaggcaag tcggtcccaa
3318001 gaacgtcgca aggatacgcc aagcggccgc ggtcaatctt gacttgtcgg ccaccgccgg
3318061 caaaccaaca ttcagccaca acgcgacaga gaggtaccca atgttcactg cccgtatccg
3318121 cgccctcgcc ggcatgtctc tgctagcctc ggcgatcgga ctggcggcct tcggagccgc
3318181 taccggcacc gccaatgccg ccccgaccca ccaacccgag tggggcacct acacctgcta
3318241 cgactacgca acccagacgt tctacgagtg ctttgacccc agctagtcgg cgaaggcctc
3318301 acacgatcgg acctagtccc gcaaaggagc taggtccgtt cggtgttgag cctgtcccgc
3318361 agccggcgat tcaccggttc gggcagcaac tcggacacgt caccgcccag catcgcgact
3318421 tctttggcca gtgaggacga cacgaacgaa taccgtggcg cggtcgcgac gaaaaaggtg
3318481 tccacaccgg caatgtgttt gttcatttgc gccatctgca gctcgtattc gaagtcggtg
3318541 ccggtgcgca gccccttcac gatcgcggtc atcccgcaag acctgacaaa gtcgaccacc
3318601 aagccatgcc cgacctgcac gcgcagattg ggcaggtgcg ttgtcgactc cttgaccatc
3318661 gcgatccgct cgtcgaggtc gaacatgccc gtctttgcag ggttgaccag gatggcaacc
3318721 accacctcgt cgaattgggc tgcggcgcgt tcgaaaatgt cgacgtggcc taacgtcacc
3318781 gggtcaaatg accctgggca taccgcgccc gtcatctgcg ccgctcctcc tcatcgctgc
3318841 gtcccccgca agcgggcacg gcccccaccg catcgtcgcc ggcggtcatg accgatgacg
3318901 ctacacgttg gcaaaaagcc gttcggccag ttccaaacgg gtgtcgccgt aaacacgctg
3318961 gggccatcgg cgccagccct ccggccacgt caacggcgcg cacgtggtcg cacgctccac
3319021 caccgctacg gttccctcgc gcgtccagcc gttggtgccc agtgcggcca ggatggcgtc
3319081 aacgtcggcg gagtcgacgt tgtagggcgg gtcggccaac accagatcca ccggggacgt
3319141 ggtcccggcc gccacgacgg ccgccaccgc gccccggcgc agcgtcgcac cggagagacc
3319201 tagggcctcg atgttgcgcg caatgacggc cgcgctgcgc tggtcggact ccacgaacag
3319261 cacggacgcc gctccccgcg acaacgcctc cagccccagg gcgccggaac ccgcatagag
3319321 gtccaacacc gccagaccgg tcagatcccg ccgcgcagtc acgatgttga atagcgactc
3319381 gcgcacccga tcggtggtag gtctggttcc gcgtggtggg acggcaatgc gccggcctcc
3319441 ggcgacaccg ccgatgatcc gggtcaagtg cgccgctctc cctcgcaagc gggcggtacc
3319501 cccacctcat cgcttcgtcc cccgcaagcg ggcggtaccc ccactgcatc gtcgccggcg
3319561 gtgctcatct gcgccgctcc tccgcaagcg ggcggtaccc ccacctcatc gcttcgtccc
3319621 ccgcaagcag gcggtacccc cactgcatcg tcgccggggc ggtcagctca ccaccaccaa
3319681 caggtctccg ccctccacct gggcggtgtc cgacaccgcc acccgctcca cggtgccggc
3319741 aaccggggcg gtgatcgggg cttccatctt catcgcctcg atggtggcga tggtttggcc
3319801 ggcgccgacc cgctcgccga cgcacacccc gaccgtgacg actccggcaa atggcgcggc
3319861 gatgtgtccg ggattgccgc ggtcggcctt ctcggcggcc ggaacggcac tggcaatgct
3319921 gcggtcgcgc actagcaccg gccgcagctg cccgttgagg atgcacatca ccgttcgcat
3319981 gccgcgttcg tcgggttcgg aaatggcctc cagcccgatc aacagctcca ccccacgctc
3320041 cagcttcacc cgatgctctt caccttggcg cagaccatag aagaactggt tggccgacaa
3320101 ttgcgacgtg tcgccgtagg cttcccggtg ctcattgaat tcctttgttg gactgggaaa
3320161 taacagcctg ttcagggtgg cctgacgctt ggctccgacc gacgataggg caatctcgtc
3320221 gtccgccgcc aattgcgcag tgggcctggc cgccccgcga ccggccagcg ccgcagtgcg
3320281 cagcggttcg ggccacccgc cgggcggatc acccagctcg ccccgcagaa atccgagtac
3320341 cgattccggg atgccaaatc gcgctggatc ggaggcgaat tcgtctgcac tgacaccggc
3320401 gccgaccagt gccagcgcca gatcgccgac caccttggac gttggcgtga ccttaaccag
3320461 cctgcccaac actcggtcgg cgcccgcgta ggcctcttcg atctcttcga atcgatctcc
3320521 cagaccaaga gcaattgctt gctggcgcag attggacagt tggccgcccg gaatctcgtg
3320581 gtgataaacc cgccccgtcg gccccggcaa cccagactcg aacggcgcat acacttttcg
3320641 taacgcctcc cagtacggct ccagggcgca caccgccgaa agcgacaggc cggtgtcgta
3320701 ctcggtgtgg gcagcggcag caacgatcga gctcagcgcg ggctggctgg tcgttcccgc
3320761 cagcggcgcg gcggcgccgt cgacggcatc ggccccggcg tgccaagcgg ccacatagct
3320821 ggcgagctgg ccacccggtg tgtcgtgggt gtgcaggtga acgggcaggt cgaagcgact
3320881 gcgcagggcg ctgaccaacc tttgagcggc cggcgggcgc aacagtccag ccatatcctt
3320941 gatcgccagc acatgggcgc cggcgtccac gatctgctca gccagtttca ggtagtagtc
3321001 cagcgtgtac agctgttcac ccggatcggt aaggtcgccc gtgtagcaca tcgcgacttc
3321061 tgctatcgca gaacctgttt cgcgtactgc gtcgatcgcc ggacgcatcg actcgatgtt
3321121 gttgagcgcg tcgaagatac gaaagatgtc gataccggtg gctgttgctt cttgcacaaa
3321181 cgccgacgtc acgatttccg ggtacggcgt gtagcccacg gtattgcggc cccgcaatag
3321241 catctgcaag cagatattgg gcattgctgc acgcagtgtg gccagccgtt cccagggatc
3321301 ctccttgaga aagcgcagcg ccacatcgta agtcgcaccg ccccaacact ccacggacaa
3321361 cagctgcggc atggtccgcg cgagatacgg tgccacccgc gacagtccgc tggtgcgtac
3321421 tcgggtagcc agtaacgact ggtgagcatc ccggaatgtg gtatcggtga ccccgaccgc
3321481 ggccgactcc cgcagccaac gagcaaatcc ttccggcccc aacttgacta gtcgctgctt
3321541 ggacccggcc ggtggtgcgg cccgcagatc aagatcgggc agcttgtcgt ccgggtagat
3321601 cgttgacgga cgcgagccat acgggttgtt gacggtgaca tcggccagga agttaaggat
3321661 cttggtgccg cggtcggccg aggcgcgcgc ggtcagcagc tgcggccgct catcaatgaa
3321721 ggacgtggtg acccggcccg ctcggaagtc cgggtcatcc aggaccgctt gcaggaacgg
3321781 aatattcgtc gataccccgc ggatccggaa ctccgcgatc gcccggcgcg cacggctcac
3321841 tgcggtaggg aggtcacggc cccgacaggt cagcttgacc agcatggagt cgaagtacgg
3321901 gctgatttct gcgcccaggt tggtgctgcc gtccaggcgg acaccggcac cgccggcggt
3321961 gcgcaacgcg ctgatccggc ccgtgtccgg ccggaagccg ttggccggat cctcggtggt
3322021 gatccggcac tgtagtgcgg cgccatgcgg tgcgatgtcc tcctgccgca ggcccaattg
3322081 ttcgagcgtc tccccggcgg caatgcgcag ctggctggcg accaggtcga cgtcggtaat
3322141 ctcctcggtc accgtgtgct ccacctgaac ccgcggattc atctcgatga agacatactc
3322201 ccctcgctcg tccagcagga actcgacggt gcccgcgcag ctgtacccga tatggcgggc
3322261 gaaggcgacc gcatcgacgc acatcttgta acgcaactcg gcgtccaggt gcggcgcggg
3322321 cgccagctcg atgaccttct gatggcgacg ctgcacactg cagtcacgct catagagatg
3322381 gatcacgtcg ccgaggttgt ccgccagaat ctgcacctcg atgtggcgtg gattgatcac
3322441 tgcctgctcg agatagaccg tcgggtcccc gaacgccgac tcggcttccc ggctggcggc
3322501 ttcgatcgcc tccggaagcg ccgcgatatc gccgacacga cgcatacccc ggcccccgcc
3322561 accggcaact gccttgacga acaacggaaa cggcatgccg gccgcaaccg acagcagttc
3322621 gtcgaccgag gccgacggcg ccgaggacat cagcacgggc aagccggctt cgcgggccgc
3322681 cgcgatggcg cgagacttat tcccagccag ctcaagcact tcggcgctgg gaccgacgaa
3322741 gctgatgccc gccgccgcgc atgccgcagc cagatccgga ttctccgata gaaacccgta
3322801 gccagggtag atagcgtcgg cacccgcccg acgggccgtc gcgacgatct cgtcgaccga
3322861 caggtatgca tgcaccgggt gaccgatgtc gccgatctgg taagactcgt ccgccttgag
3322921 acggtgctgc gaattgcggt cctcgtacgg ataaacggcc acggttccga cgcccagttc
3322981 gtaggcggca cgaaaggccc ggatcgcgat ctccccgcga ttggcgacga gcaccttgga
3323041 aaacacgtgt ggctccctta tccggatgtc tcagatcagc gtcgaccaat agtcccaaaa
3323101 gcggaccatg atcagcagga atactgtcgt gaaccagagc gtggccagcg accatcgcca
3323161 ttgatagagc agccgtgccc cgacgcgctc ctggcttccc cggttttccc gcatcggacc
3323221 gaaaacgatg gacgcgacca ccaccagcag tgtggcgatg accgcccaga ccaccatgca
3323281 gtatgggcac agggcaccga tacggtacag gctctggaat atcagccaat gcacgaacgc
3323341 cacaccaacc aggatcccga ccgccaggcc gatccaatac cacctgggca acggcacttt
3323401 cgccaccgcc agcaccccgg tgaccaccac cacggtgaag cccgcaatgc cgagaagcgg
3323461 gttgggaaag cccagcaacg acgcctgcgg tgtggtcatc accgagccgc acgacactat
3323521 cgggttgaca ttgcatgacg gcacatagat cggatcgagc agaatcctga ccttctccac
3323581 cgtgagcgtc atcgaagcga acagcccgat cacaccgccg atcagcaccc accacgcgct
3323641 aggcaccggc acccgcaccg cagccgggtc gccggatcgc tcggcaggtc gagctgccac
3323701 cacaatcgtc aggatgtcgc ggtagcagcg gccgagtcaa tgcccggcac atcacccaca
3323761 atttctttga tcttggcgac cagcgccgcc ggcgtcgacc actcgtactc tgtgccattg
3323821 acccggaccg tcggggtcgc gtgcacgttg accgccgccg ccagcccgtc gactttttcg
3323881 atgtacttgc cgctgttgat gcagtcgggc accttgccca cgacgccggc ttcgcgggca
3323941 agttcgatca accgcgcgtt gtcggggaaa tccttgccga gctcggcagg ctggatgtcc
3324001 ttgctgaaca aggcggcgtg gaagcggcgg aacgcctcga tcgattcgtc ggcaacgcaa
3324061 taagccgcag cagccgctcg cgacgaatag tgttgattgc tggcgctatc gagaatggcc
3324121 accatcgtgt aatcggccgc gacagcgccg atgtccacga gcttggacac ggttggcccg
3324181 aaaccgcgct cgaatatgcc gcacgccgga cacaggaaat cctcgtagaa ggacaccacg
3324241 gccttggggt tgctggttcc gggctgggtg accagcttgc tcgacgtcac ccgtactgca
3324301 tcgccggggc ccgcgacgcc gtccttcttg tcgtcgcgcg acgtcacgat gtagaagacc
3324361 aggacgacgg caaaaacgac gacgatggtg gtgccaccaa tctggacgag ccggccgaag
3324421 ctgccgtcgg cggacttcag atcgaatcgc ggggggcgtt tggatttgtc ggccacagtt
3324481 tcgctgatcc tcacgtgctc gatttgtcgg cttgtcgcgg ccgcggtcag gcgacggcgc
3324541 ctctagcgta ccggcggcaa gccagcctcg actcaaaccc ggctaaggtg cgcgcgcagc
3324601 gcggagatca gctcgttggt cccggcagca ctgcctcccc ccagctgaaa caggttgagg
3324661 aagccatgcg tcagcgaacc cagataccgc aagtccactg cagtcccggc agcccgcagc
3324721 gccttcgcat agctttctcc ttcgtcgcgc aatgggtcga agccggcgac cgcgatgaga
3324781 gcaggcgcca gcccggacag cgattcggcc aacaacggcg acaaccgcgg atccgccgga
3324841 tcgacatcgg aatccctgag gtattgcgtg tggaaccaat cgatgtcccg cttggtcagc
3324901 aggaagccat tgccgaacag gcccattgag cgagtctgtg cggtgaaatc ggtcctggga
3324961 tacagcagcc actgcagcac cggggtgggc ccaccctcgt agcgagcctt gtcgcgcgcc
3325021 aactgacaca ccacggccga caggttgccg cccgcactgt ccccgcccac cgcgacccgc
3325081 ccggggagcg caccgaactc atcggaagcg tgctcatggg cccatacaaa agccgcatag
3325141 gcatcttcaa ccgcggccgg cgccggatgc tcgggagcca accggtagtc gatcgacagt
3325201 acctggatgt cggcgtcgcg acaggtcaac cggcacagcg cgtcatgggt gtccaagtcc
3325261 ccgagcgtcc agccgccacc gtggtaaaag accagcagcg gcgtggcgcc accgccgctg
3325321 gggcggtagt gccgcgccgg gatctcaccg gctggtccgg gtattgacag gtcggtcacg
3325381 tcgacgtgga tctgcggacc gggcatcgcc tcgcatatcg cgcgcatgtg cgcgcgagag
3325441 gcgacgatgt cgtcgtctac ggccaggccg tcgacaccga agatccgcga agtcgacaac
3325501 atcagctgca gggtggggtc aagcgtattg ccatcgataa tgaccgatcg gccggccgac
3325561 aggatccgtt tggcaggcgt cgggatccac ggaaggacct tgactccgac gttgacgacg
3325621 gtgccctgca cacgccgtgt ccacatgcgc gggtggtttg ctccgagacg gaggtctgcc
3325681 acacctggca gactcttggt catgggctgc tccctacaaa actctgtcac gcgcagcaac
3325741 ggacactcga tccgcgccgt caggctggat gtctttcggg tcctgccggc cgacaccggg
3325801 caagcggtag gtgccgcgag tccggcgtgc ccaacggcca actctacgtg gtgaccaaag
3325861 tgttgaatgc cgaccagcac tattcgcggc ttacgccgcc gtcgccgaag gctgtggctc
3325921 agcacctgcc caggtgttga ttaggtggca tatccaactc ggtaatatcg tgatccccaa
3325981 gtcggtgaac ccaatgcgga ttgcgagcaa cttcgacgcg ttcgatttcc ctcgctcgat
3326041 gacggaaccc ggcttggtcc gaatccgaaa accttcaatt tcacaggcag gtgagatgac
3326101 gtgactggcg agtcgggcgc cgccgccgca ccctcgatta ccctcaacga cgagcatacg
3326161 atgccggtgc ttggcctcgg cgtcgcggaa ttgtcggacg acgagaccga acgtgcggtg
3326221 tccgcggcgc tggaaattgg ctgccggctg atcgacaccg cctacgccta tggcaacgag
3326281 gccgcggtcg gccgcgcaat tgcagcctcc ggcgttgccc gcgaagagct gttcgtcacc
3326341 accaagctag ccacccccga ccagggtttc acccgttccc aggaagcatg tagagccagt
3326401 ttggaccgcc tcggcctcga ctacgtcgac ctttacctaa ttcactggcc ggccccgccg
3326461 gtgggcaagt atgtggacgc ctggggaggc atgattcaat cccgcggaga gggccatgcc
3326521 cgatcgatcg gcgtgtccaa cttcaccgcg gagaacatcg aaaaccttat cgacctcaca
3326581 ttcgtcacgc cggcggtcaa ccagatcgag ctgcacccgc tgctcaacca ggacgaactg
3326641 cgcaaagcta acgcccagca caccgtcgtc acacagtcct actgccccct ggcactcggc
3326701 aggctgctgg acaacccaac cgtcacatca atcgccagcg aatacgtcaa gacgcccgca
3326761 caagtgctgc tgcggtggaa cctgcaattg ggcaatgcgg tggtcgtccg ctcggccaga
3326821 cccgagcgca tcgccagcaa cttcgacgtc ttcgacttcg agttggcggc cgaacacatg
3326881 gatgcattgg gcgggctcaa tgacggcacc cgggtgcgcg aggatccact gacctacgcc
3326941 ggcacctgat acgccgccga ctgtgaaccg cgcgacgtct cctcggcgtg tcacgtcgtg
3327001 agattcaccg tcggcgcgtg gactagcccg tcgggcaggt ggccgcggcc tgacgcagta
3327061 cgtcggacga tggctgatcc actggcagtg aatagccgcg cagcacggcg atgaattgca
3327121 tcgcgtactg acaggcgaag gccttgttgg gtggcatcca ttgggccggt ggcgaatcgc
3327181 ccttgtcctg atttgcctgc ccctgcacgg ccagcaggtt ggccggatcg ttggcgaagc
3327241 gcattcgctc ggagttcggc caccgatagg cgcccatgtc ccaggcatac gagagcggaa
3327301 cgatgtggtc gatctggacc gattggccaa cactggcgcc gcgttggaag gcaacggtgg
3327361 tgttggtgta cggatcgcgc agggtgccgg tggccaccgc attcggacac cgcttgatcg
3327421 acacatatgt cttgtcgacc agatcccggt cgaggatgtc gtcgcgggtg tcgcacccgt
3327481 tgtgccctcc cggcgcgtca ttgcgatcgt cccaggggtg accgaatgcg gacctgcggt
3327541 agtcgtagcg gtggatccgt ttgggtagca cggcgatgcc ggcgagcacg tcggcaccgg
3327601 gttgcacggt tggcacgcca gcgcgggcgg cgaactcgtc agcgtgcctg cccgccgatg
3327661 atcccagcgt ctgatacgcg accaccagcg ccagcgccgc gatcgccgac agccacagta
3327721 gcgttctgcg gttcatgact tatctaagta ttcgatgcgg tcggtgctgg tgaatcgcgc
3327781 ggccatcagc gccaatgcgg ggtctgtggg gttcttgtaa gcctcgatgc agaagtcccg
3327841 cgcggccact atgtattcct cgtgttcggc caatgacagc aaccgcagcg tgatggcctt
3327901 gccggattgg ttgcggccca gcacatctcc ctccttgcgc tccttcagat ccagatcggc
3327961 gagggcgaac ccgtccattg tcccggcgac cgcacgcagc cgctgacccg ccggcgtatc
3328021 cggcggcacc cagctggcca gcagacacac gctgggatgt tcgccgcgcc cgatgcggcc
3328081 gcgcagctgg tgcaattggc tgatgccgaa ccggtcggcg tccatcacca gcatgaccgt
3328141 agcgttgggg acatcgacgc caacctcaat gaccgtggtg cacaccagca catcgacctc
3328201 accggcccgg aaagccgcca tcgcagcgtc cttgtcgtcg gccgacaacc gtccatgcat
3328261 gagcgccaac cgcaactctg cgagctcggc ggaacgcaac cgggagaaca ggccttcggc
3328321 agtggccgat ggtcggacgc cgccttgaac gtcggtgtcg tcggactcat cgatgcgggg
3328381 cgccaccaca taggcctggc ggccggcggc agcctcttcg atgatgcgcc gccaggcgcg
3328441 gtcgagccag gcgggcttgt ccttgacaaa gatgacgttg gtggcaatcg gctggcgccc
3328501 gagcggaagt tcgcgcagcg tagaggtttc caggtcgcca tagacggtca gcgcgaccgt
3328561 gcgcggtatc ggcgtcgcgg tcatcaccag caggtgcggg gtaatgccgg cgggggcctt
3328621 ggcgcgcaac tgatctcgct gctcgacacc aaaccggtgt tgctcgtcga ccaccaccat
3328681 gcccaggttg tgaaagtcga cggcctcctg cagcagcgcg tgcgtgccga tgacgatgcc
3328741 gacctgaccg ctggcgattt cggcgcgaac ttgcttcttc tgccctgccg tcatcgaacc
3328801 ggtgagcagt gccacccggg tggcgttttc ggcgcctccc agttggccgc ccatggccag
3328861 cggccctagg acatcgcgga tcgatcgcaa gtgttgtgcg gcaaggactt ccgttggcgc
3328921 cagcagggca cactggtaac ccgcgtccac catctgcagc atcgccaaca ccgcaacgat
3328981 cgttttgccc gagcccactt cgccttgcag caggcgattc agcgggcggt tcgccgcgag
3329041 cccgtcggac aacacgtcga gcacctcacg ctgtcccgcc gtcagctcaa aaggcaaccg
3329101 ccgcagtagc tcagcggcaa gaccgttaga tttccaggcc gccgagggcc cggattccga
3329161 cagttcaccg tgccgtcggg ccaccagcgc ccactgcaga cccacggcct cgtcgaaggt
3329221 caggcgttcc cgggcgcgct cgcgtaacga ctggctttcg gcaaggtgaa tggcgcgcag
3329281 tgcctcgtcc tcggggatca ggccgtgctt ggcgcgtagt tccgcgggca acggatcatc
3329341 gacccggtcg agaacatcga gcacctgccg cacgcatttg aagatgtccc agctctgcac
3329401 ttttgtgctg gccggataga tcgggaagaa acgacgctcg aactcctcca cgaccaattc
3329461 accgctgatg gccttggagg catcagcgat acttttgagc gacctggtgc cgtggttctt
3329521 cccgtccggc gagtcgagga tgagaaacgc cggatgcgtg agctgcatcg cgcccttgta
3329581 gtagccgact tccccggaga gcatcacctt cgtgtgcttg gtgaggtccc gcatgatgta
3329641 gtccgcgttg aagaacgtgg ccgtcacctt gttgcggccg ccgccgacgg tgatgcgcag
3329701 acatttccga ttcggcttct ttttcatcgg aaacgaatac gtatcggtga tcacgtcgac
3329761 gatggtgatg tgctcgccag cttccggtcg cgcgtcaccg atacccaccc gcgccgcgcc
3329821 ctcgacgtag ctgcgcgggt agtggcggag caggtcgtcg acggtccgca tgccgaactg
3329881 ctcgtcgagg gcatcggctg ccgtggcgcc gaggacgcga tcgagccgat cgcttaacga
3329941 cgccaccgct actcgacccc gatcagcagc gcgtcgccgc ggtgtccggt gcggtaggag
3330001 accagctcgg tgcctggatg gtggtcgtgc acatgccgtt ccaggacgac agccacgtct
3330061 tcggttacgc cggcgccaat tagcaccgtc accagatcgc ctcccgatgc caacaacagg
3330121 tcgaccagac cgatggccgc cgcggcgaca tcgtcggcga cgatcagcac ctcgtcgccc
3330181 gcgataccca gaccgtcgcc cggcttgcag gtaccggccc aggtcagcgc cttttgggtg
3330241 gcaatgcgca ccgatccgtg ccgggaagca ccggcggcac gggccatgct gtagccgtcg
3330301 tcgacggcct ggcgggccgc gtcatgcacg gccagcgcgg ccaacccctg caccatcgat
3330361 ccggtcggca cgggtaccac gtcgacgccc cagccgatcg ccgcggtaca cccggccacc
3330421 agttcttcgg cggccacata gccattgggc agcaccatca cgtgcgcggc gccggtgtct
3330481 accacggccc gcaccagctg gtgggcactg atatcggcgg ccggtgtcac ggcgtctgga
3330541 cccggtcgca gcacgcaggc gccctccccg gcgaacagct cggcggcacc gtcgccgtcg
3330601 acgaccgcca gcacggcgcg gccccgcgtc cagccaccgg ccggcaatcc gctggtcccg
3330661 gaaccgagcg ccgagatcac gatccggcta actcgcccca ccgccaatcc ggcttccacg
3330721 gcggcaccgg cgtcgtcggt gtggacgtgt acggagtagc tgtcgggcgg agcagcggcg
3330781 atggccaccg actcacccaa ttccttgagt cgatcccgca actggtccgc cgctgcagca
3330841 tcacataccg ccaacagata catcacctcg aattgcgggg cggggcgttg ggtagccgtg
3330901 tcggtcggca acgcgcgcgg cgagggttcg tagaccgccc gggcaggtgc ctgcccgcag
3330961 atggtggagc gcaacgcgtc cagcagaacc agcaggcccc gtccgccggc gtccaccgcg
3331021 cccgcatcgg cgagcacgtc aagctgttcg ggggtctttt ccagcgcgat gaccgccgcg
3331081 tcaccggcgg cggtgaccgc accggccaac ccctcgtgcg cgcactggtc gacggctccg
3331141 gcggcggccc gcagcaccga gacgatagtt cccggcacct ccacgccacc catcgacgcg
3331201 acgaccaact cgacgccgcg ccacaacgcg gccccgaggg cgttggcgtc gaccgcccgc
3331261 aataccgcgc cagaggcggc ggccgcagtc gcggtcacct ctgcgatccc gcgcaggatc
3331321 tgggacagga tcacgccgga gttgccgcga gctccgttca acgcgcgccg gccgcgagag
3331381 cggccgcaac ccgcgccacg tcttcggcgt cagcctgcga attcgcgtgc aaatcagctt
3331441 ctacgaccgc ggcacgcatg gtgaacagca tgttgacgcc ggtatcggag tcagcgaccg
3331501 ggaacacatt gagccggttg atctcgtcga tgtggaggat cagatcgctg acgacggcgt
3331561 gtgcccagtc ccgcaaggcc gaggcgtcca acggccgatc cgccgtcccc actacaacac
3331621 acctcctccg caacacacct cctccgcgcc agcccgcgcc ccgagcctaa ccagacgtgg
3331681 tgacagcacg gtcacgacgc cgctctcccg gccaaggcgg gtgctgacat gtccgcgaag
3331741 ggctgatcgt tttggcgcta ccgcacaaca atggctatcc tgtgctagcc gcgggctaca
3331801 cgtaggcgtc ccggccaggt cgccggacct aagagatttg aggagcttga cgaatggccg
3331861 ctgtgtgcga tatctgcggg aaaggccccg gcttcggcaa gtcggtgtcg cactcccacc
3331921 gccgcaccag ccgccggtgg gatccgaaca tccagactgt gcacgccgtg acccgtcccg
3331981 gcggcaacaa gaagcgactc aacgtttgca catcctgcat caaggcgggc aagatcaccc
3332041 gcggctgacg cccggtaaca cctgcacgac tcagggcaac cgccaatcga tcggctcggc
3332101 acccatcccg acgagcagtt cgttggcgcg gctgaacgga cgcgagccga agaacccgcg
3332161 cgatgccgat agcggtgaag gatgcggcga ctcgatcgca acgcagttgc ccgcggccag
3332221 catcggcttc agagtcgacg cgtcacgacc ccacaggatc gccaccagcg gcgctgcgcg
3332281 cgccgccagg gcgcgaatcg cgcattccgt gaccgcttcc cagcccttgc cccggtgcga
3332341 cgccgggttg ctgggtcgca ccgtcagcac cctgttcaac agcaacacac cgcgttgcgc
3332401 ccagggcgtc agatcgccgt tcgagggcag cggatagccc aaatccgcgg tgtactcgtc
3332461 gaagatgttg gccagactgc gcggccacgg acgtacatca ggggccaccg agaagctaag
3332521 acccacagca tgtcctggag tcggataagg gtcttggcca acgataagga cacggacgtt
3332581 gtcgaacggg aaagtgaagg cgcgcaacac attcgatccg gcgggcaggt atctgcgccc
3332641 ggccgcgatc tcggcccgca agaactgccc catgtgggcc acctggtcgg ccaccggctc
3332701 gagcgcggcg gcccaccccc gctcgacgag ctcactcaac ggccgtgcgg tcactgcatc
3332761 cctttcgcgt acagacggtc accgcgtcac cctagcgaac cttgattgtc tggctcccca
3332821 aacgattgcc agcccgcgta tccagtccac tcctcgccgt cgaccagcac cctagccggc
3332881 ccgtcgagaa cccggccaat ggtgcgccac ccggccggca ccggaccgac gaaacaggcg
3332941 accagggcat gatcttcacc cccgcttagc acccacggcc aggggtcggt gcccagagcg
3333001 gttgcggccg cagtcaaagc gtcgcggtca gcggccaacg ccgcggcgga caggtcgatg
3333061 cgcacgccgg atgcctcggc gatgtgccgc agatcggcga gcagcccgtc ggagacatcg
3333121 atcatcgctt gagccccgac agccgcggcc gccgcgccgt ggccgtaggg cggctgcggc
3333181 accaaatggc ggcggcgcag ttcggcgaag tcttcaatcc cgttgcacca cagcgcatag
3333241 ccagcagccg agcggcccag ctcaccgacg acggccagca ccgagccggc cttcgccccg
3333301 gagcgcagca ccggggcacg accgtcaagg tcaccaatcg cggtgaccga caccacccac
3333361 tgccggcagc tgaccagatc gccgccgacg atgccggcac caatgcgccc cgcctcctcc
3333421 cacattccgt cgaccaacgc gctcgcctgc gccgccggcg tctcagcggg tgctccaaag
3333481 ccgaccacga acgcggtggc ccgcgccccc atcgcctcga tgtcggcggc attctgggcg
3333541 atcgccttgc ggccgacgtc ctgcggtgtc gaccagtcca gccggaagtg actatcttgc
3333601 accagcatgt ccgtcgacac cacagtgcga ccatcgccgg cagacaccag cgcggcatcg
3333661 tcgccgggcc cgagcagtac cgtggcgggt tgtcggcgcc cccgcaccag ccggtcgatc
3333721 acggcgaact cgccgagctg ctgcagcgtc ggggactccg ttgcaagtga gtgatcttta
3333781 gtggtcacgc gacttgcacc ccgtctcggg gttgttcggc agccttgggg ctgcttccct
3333841 tccgcgcttc acagccacct gccgggcgag gcccggtctt acggtcggct ccacgcttga
3333901 cggcggcccc aactgggccg acgatgctgg atgtttcctc gtagcgtgcg aggttgatgg
3333961 cagcgcagtc atcacgctga tggaccactg agcatcggtc gcattgccat tgttcgtccc
3334021 agccgatgtc ttgcacatgc cggcaggcgt ggcaggtttt cgacgacggg aaccagcggt
3334081 cggcgaccac cagcgccgac ccgtaccaga ctgtcttgta ggacaagtgc cgacgcggag
3334141 tgcccagggc cgcatccgac agtccgcgcc gacgagcgcg ggcacccggc aacccttttt
3334201 gccgcaacat ctctgtcgcg tccaagcctt cgacaacaat gcggccgtgg gtttgagcca
3334261 accgtgtcgt caggacgtgc aggtgatggg tgcggacatc gttgacccgg cgatgcaacc
3334321 gggaaatctg agtggtgcgc tcacggtagc gccgtgaacc tttcgtgcaa cgcgaacggg
3334381 cccggcacac gtggcgtagc tcgcgcagcg cggcgccgag cggtcgtggg ttctcaacct
3334441 gctcgatcgc cgtgccgtca gcggtggcga ccgtcgccag gcgccggacc ccgacatcga
3334501 caccaacccg cgaaccgggg tgcaccacct tcggctgctg cggacgctgg acaagcaccc
3334561 gcacactggc atccagacga gtgccgttgc ggcgcaccga gatcgccaat actcgcgccc
3334621 gaccggcctt gatcaggcgt tcgatacggc gggtgttctc gtgcgtgcgg acggtcccga
3334681 tgaccggcag ggtgaggtga cggcggtcgg gttccacacg catcgctccg gtcgtgaacg
3334741 acactcgatc ctggtcgcgg cctttgcgtt tgaaacgggg aaacccgacc cgtttaccgg
3334801 cgcgtttgcc ggcgcgggag gtctgccagt tccagtacgc ctcgaccgca cccgcgatgc
3334861 catcggcgta ggcctctttt gagcattcag gccaccacgc gacaccggtc tcggtgttga
3334921 cgcacacgtc gtccttgacg gtgttccagc gtttgcgcag cacgcgcagc gacggtttcg
3334981 ctgtcacggt cccgctggca tgccacgcct ggatgtcggc tttcagggtg gccacggtcc
3335041 agttgtatgc cttgcgacga gcaccgaaat gccgtgccag cgccttggcc tggtcctcgg
3335101 tcgggtccag cgtgaaccga aacgcttgga ccgtccagcc atcgggaacc tcgaacttgg
3335161 gcatcaggcg gcctcatggt cctcgccagc agcggccgcc aatgcgcgct tggttcgatt
3335221 ctcggcagcc cgtttgccat acagacgggc gcacatcgac gtcaggatct cggtcatatc
3335281 ccgcaccagg tcgtcatcga cctcggcaga gtcgactacc accagttcgc ggccctgcgc
3335341 cgcaaacgct gcctgcacgt acttcgagcc caaccggcag aaccgatccc ggtgctccac
3335401 cacgatccgg tggactgacg ggtcgcgcag cagtgaaagg aacttacggc ggtgctcgtt
3335461 gaacgcggaa ccgacctcgg tcacgacctt gtcgactggc atctgttggg ccgtggccca
3335521 cgcggtcacc cgcgcgacct gccgatccag atcggctttc tgatcggccg acgacacccg
3335581 tgcatacacc gcggtcggtg atcgcatgcc agcgtcccca gccggttcgt cgacgagaat
3335641 cagtcggccc actcgcctcg ccatcaccga caacagacca gcacgaaacc agcggtaggc
3335701 ggtccccgga gcaacaccgt tgcgctccgc ccacgtcgcc aggttcatat ctctgttcct
3335761 accgcacgcc actgacaact accgaccact caacccgcaa cagctggcac cccccgatgc
3335821 gtcgtcgccc acgccgcctc cttcggcccg ttctggccct gtggaccttc gaacacctcg
3335881 cccgacctgc ggtaagttga gtcactgccg gcgcgagcgg accgcgccag tgtatgagag
3335941 caaagaggtg gccgcgcagg tgacaggcga gtccgacggg ccgccgcgcg ccgtgctgat
3336001 cgccgcggcg gcgctggcgg cggcggtgat cggggtaatc ctggttgtcg cggcgaaccg
3336061 ccagccgccg gagcgaccgg ttgtcattcc ggccgtgccc gctccgcagg ccaccggtcc
3336121 cggctgcaaa gcactgctgg cggcgctgcc tcaacgactc ggcgagtatc ggcgcgcgcc
3336181 cgtcgcggag ccgaccactg cgggtgccac ggcctggcga acggggccaa acagcacacc
3336241 ggtgattttg cgctgtggac tcgaccgccc ggccgagttc gtggtgggtt cggccatcca
3336301 agtcgtcgat cgggtgcagt ggtttcaggt ggccgcgcaa aacccggacg agccaggccg
3336361 gtccacctgg tacaccgtgg accggccggt gtatgtggcg ctgacactcc cctcgggatc
3336421 ggggcccacc gcgatccagg aattgtcaga cgttatcgac cacaccatcc ccgcggtacc
3336481 catcgacccg gcgccggctc gctagtgccg atcgcaagcg cggcgcttgc gccgggcgcg
3336541 gcgggtcggc accatcgggc taagtgccga tcgcaagcgc ggcgcttgcg ccgggcgcgg
3336601 cgggtcggca ccatcgggct aagtgccgat cgcaagcgcg gcgcttgcgc cgggcgcggc
3336661 gggtcggcac catcgggcta agtgccgatc gcaagcgcgg cgctagcgcc gggcgcggcg
3336721 ggtcggcacc atcgggctaa gtgccgatcg caagcgcggc gctagcgccg ggcgcggcgg
3336781 gtcggcacca tcgggctagt gcaggcccac gccgcgggcc aatgtcgtct cgatcatcgt
3336841 cgccagcagg gtcggatagt cgacaccgct ggccgcccac atccgcgggt acatcgagat
3336901 cgtggtgaat cccggcatcg tgttgatctc gttgatcacc ggaccgtcgt cggtgaggaa
3336961 gaagtccacc ctggccagac cccggcagtc gatagccgcg aacgcccgga tcgccagctg
3337021 acgaatcgcc tctgcgacct ggtcatcgac cttggcgggc acgtccaatt cggctgcgtc
3337081 gtcgagatac ttggttgcga agtcgtagaa agagtcctcg cgtccccgca ccccggccac
3337141 ccggatctcc cccagcgtgc tggcttccag tgtgccgtcc ggcatttcga gcacaccgca
3337201 ttccagctcg cggccgctga tcgcggcctc gacgatgacc ttagggtcat gccggcgggc
3337261 ccgcgcgacc gcggcgggca gttgatccca actcgacacc cggctaacac cgatcgacga
3337321 gccgcctcgg gcgggtttga cgaacaccgg taagcccagc cgttcgcact cctggcggtg
3337381 cagtgtcgac cgcggcggac gcagcaccgc gtacgcaccc accggaagtc catcggcggc
3337441 gagcagcttc ttggtgaact ccttgtccat gccgacggca ctggccagca caccggcgcc
3337501 cacgtagggc accccggcga gttcgagcag tccctggatc gtgccgtcct cgccgtacgg
3337561 gccgtgcagt accgggaaca ccacgtcgac cgactccaga acctcgccgg ccccgggcgg
3337621 cagcgacacc aactggccac cacgccgcgg atcggccggc agcgccagct cggtgcccga
3337681 tcctgatttg acctgaggaa gctcccggtt ggtgatcgtc agggcgtcgg ggttggcgtc
3337741 ggtgagcacc cacgaacctg ccggggtgat acccaccgcg atcacgtcga accgccgcga
3337801 gtccaggttg cgcaggatgc tgccggcgga cacacacgag atggcgtgct cgttgctgcg
3337861 cccgccgaac acgacggcaa cgcggacacg ccgatcacgc cggtcgttag cactcacaac
3337921 ctgcagaggc taccgggtca ggcagacggg ctcccacgag ctgcagtttt cggtcgtgcc
3337981 ggcccgtgcg aggctcattc gggcttggtg cggcgaccca gcagcagcgt tatcgcctcg
3338041 tccaccgaca gccctttatg acagacccga tgcaccgcgt cggtgagtgg catttcgacg
3338101 tcgtagctgg acgccagcgc gagcacggat tcgcacgacg tcacgccttc gacgacatga
3338161 caagccttgc ccgccgactg caacgtttcg ccccggccca ggcgttcgcc aaacgatcgg
3338221 ttgcgcgaac gcggtgaggt gcaggtggcc accagatcac cgacccctgc cagaccggcc
3338281 aacgtcgcgc cgttggcgcc gagcgccgtc ccgagccgga tgatctccgc caggccccgg
3338341 gtgatgatcg cggccgcggt gttttcgccc agcccgatgc ccaccgccat tccgcacgca
3338401 agcgcgatga tgttcttgca cgccccgccg atctcggtgc cgacgacatc ggcgttggtg
3338461 taggggcgga agtacccgct gttcagcgcg cgctgcaagg caaccgcgcg gccggagtcg
3338521 ctgcacgcga cgacggtagc ggcgggctgg cattcggcga tctcgctggc caggttgggt
3338581 ccagagatca ccgcgacctg cggcggctcg gcaccggtca ccgagatgat gacctggctc
3338641 atccgcatca gggtgcccaa ctcgatgccc ttggccagac tgaccaaggt cgcaccctcg
3338701 ggcaacaggg gagcccaccg ctcgagattg gcccgcatgg tctgcgcggg cactcccaac
3338761 agcaccgtgg atgcgccccc aagtgcctcc tcggcatctg cggtggcatg aatgctcggt
3338821 ggtaacagcg caccgggcag atagtcgggg ttatatcggg tggtattgat ctgatcggcc
3338881 acctcagctc gccgcgccca cagcgtgacc tctccgcccg cgtcggccag caccttagcc
3338941 agggccgtgc cccatgcacc ggcgcccatc accgcgacgg tgcttgctat tccggccatc
3339001 cacacacact aatctgcgcc gcggttgccg tcgggaccgt gcctgggccc cggccacgac
3339061 cgtggcggca atgccgtcga agtgtgccgc gtggatcgac gctggcagga tgacttcatg
3339121 agcggcacac cggacgacgg cgatatcggc ttgatcatcg ccgtcaagcg cttggccgcg
3339181 gccaaaacca ggctggcccc ggtgttctcg gcgcagactc gcgagaacgt ggtgctggcc
3339241 atgctcgtcg acacgttgac cgccgcggcg ggtgtcggtt cactgcgctc gatcactgtt
3339301 atcacccccg acgaagccgc ggcggctgcg gcggccgggc tgggcgccga tgtactggcc
3339361 gacccgacac ccgaagacga tcccgaccca ctgaacaccg ccatcaccgc tgccgaacgc
3339421 gtggttgccg aaggggcctc caacatcgtt gtgctgcaag gcgatttgcc ggcattacag
3339481 acacaggaac tcgccgaggc aatctcggcc gcacgccacc atcggcgcag cttcgtcgcc
3339541 gaccggcttg ggaccggcac cgcggtactg tgtgcgttcg gcaccgcgct gcacccgcgg
3339601 ttcgggccgg attcgtccgc gcggcaccgc cgttcgggcg ctgtcgagct gacaggagcc
3339661 tggccgggcc tgcgctgcga tgtcgacacc cccgccgacc tgacggccgc acgccagctc
3339721 ggggtagggc ccgcgaccgc gcgagcggtc gcacatcgtt gaccgggacg gggcaacgcc
3339781 ggcgaggcat ccagggggtg aacggcagac caacggcgaa cggatgcctg ccgagtgctg
3339841 gcaaccccac ccaatgatga gcaatgatcg caaggtgacc gaaatcgaaa acagtcccgt
3339901 cacagaggtg cggccagagg agcatgcgtg gtatccagac gactcggcgc tggcggcacc
3339961 gcccgctgcc acccccgccg cgattagcga ccagctaccc tcggatcgct acctgaaccg
3340021 ggagctgagt tggctggact tcaacgcgcg cgtgcttgcc ctggccgccg ataagtcgat
3340081 gccattgctc gagcgcgcca agtttctggc aatcttcgcg tccaatctcg acgagttcta
3340141 catggtccgg gtggccggcc tcaaacgccg cgacgagatg gggttgtcgg tgcgctccgc
3340201 cgacggtcta acaccgcgcg aacaactagg ccggatcggc gagcagactc aacagctcgc
3340261 cagccggcat gcccgggtgt tcctcgattc ggtgctaccc gcgctcggcg aggaaggcat
3340321 ctacatcgtc acctgggccg atttggatca ggctgagcgc gaccgattgt cgacctattt
3340381 caacgaacag gtcttccccg tcctgacccc gctggccgtc gatcccgccc acccgttccc
3340441 gtttgtcagc gggttgagct tgaacctggc ggtcacggta cgccaacctg aagacggcac
3340501 ccagcatttc gcgagggtca aggtgcccga caacgtcgac cgcttcgtcg aactcgctgc
3340561 acgtgaggcc agcgaggaag ctgcggggac cgaaggccgg accgcgctgc ggttcctgcc
3340621 gatggaggag ctgatcgcgg ccttccttcc ggtgcttttc ccgggtatgg aaatcgtcga
3340681 gcaccacgca tttcgcatca ctcgcaacgc tgacttcgag gttgaagagg atcgcgacga
3340741 ggacctactg caggcgctcg agcgagaact ggcccgccgc cggttcggtt caccggtgcg
3340801 actcgagatc gcagacgaca tgaccgagag catgctggag ttgctgcttc gcgaactcga
3340861 cgtgcatccc ggtgatgtca tcgaagtgcc cgggctgctc gacctatcgt cgttgtggca
3340921 gatctacgcc gtggaccgcc cgacgcttaa ggatcggaca ttcgtcccag ctacccatcc
3340981 cgccttcgcc gagcgggaaa cacccaaaag catcttcgcg acgctgcgcg aaggcgatgt
3341041 gctggttcac catccgtatg actcgttctc caccagcgtg cagcgattca tcgaacaggc
3341101 cgcggccgac cccaacgtgc tggcgatcaa acagacgctg taccgcacct ccggcgactc
3341161 gccgatcgtc cgggcgctga tcgacgccgc cgaagccgga aagcaagtgg tggcactggt
3341221 cgagatcaag gcacgcttcg acgaacaggc caacatcgcc tgggcgcgcg cactagaaca
3341281 agccggcgtg catgtggcgt acgggctcgt cgggctcaag acgcactgca agaccgcctt
3341341 ggtggtgcgc cgcgaaggtc cgacaatccg gcggtactgc catgtcggca ccggcaatta
3341401 caacagcaag acagcacgac tctacgagga cgtcggactg ctgaccgctg cacccgatat
3341461 cggcgccgac ttgaccgact tgttcaattc gctcaccggc tactcacgca agttgtccta
3341521 ccgcaacttg ttggtggccc cgcacggaat ccgcgccggc atcattgacc gcgtcgagcg
3341581 ggaggtcgcg gcgcaccgtg cagagggtgc ccacaacggc aaaggccgca tccgactcaa
3341641 gatgaatgcc cttgttgatg agcaggtcat cgatgcgctg taccgcgcgt cgcgagccgg
3341701 tgtgcggatc gaggtggtgg tacgcggcat ctgcgcgctg cgtccaggtg cgcagggcat
3341761 ttcggaaaac atcatcgtgc gctcgattct cggccgcttc ctcgagcact cgcggatcct
3341821 ccatttccgt gccatcgacg agttctggat cggcagcgcc gacatgatgc accgcaacct
3341881 cgaccggcga gtcgaggtta tggctcaagt caaaaacccg aggctgaccg cgcagctgga
3341941 cgaattgttc gaatccgcac tggacccgtg cacccggtgc tgggagctcg ggcccgacgg
3342001 gcagtggacc gcgtcgccgc aagaaggcca tagcgtgcgc gaccatcagg aatcgctgat
3342061 ggaacggcac cgcagcccct gacactgcgt ggtgattccc gctgctgcac cgaccacatc
3342121 cacgaccgcg agcagcctgg ccgaattgac ctgcaggagt tgaggtgtcg atccagaact
3342181 cgtccgcccg ccggcgctcg gcgggccgga ttgtgtacgc cgccggtgcg gtgctctggc
3342241 gacccggcag tgccgattcg gaagggccgg tcgagatcgc tgtcattcac cgcccccgtt
3342301 acgacgactg gtcgctgccc aagggcaaag tggatccggg cgagaccgca ccggtggggg
3342361 cggtgcggga gatactcgag gagaccggtc accgcgccaa cctgggtagg cggctcctga
3342421 cggtgaccta cccgaccgac tccccttttc gaggcgtcaa gaaggtgcac tactgggcag
3342481 cgcgcagcac cggtggggaa ttcacccccg gcagtgaggt cgacgagctg atctggttac
3342541 cggttcccga cgcgatgaac aagcttgact acgcccagga tcgaaaagtc ctgtgccggt
3342601 tcgctaaaca cccggcggac actcagacgg tgctggtggt gcggcatggc accgcgggca
3342661 gcaaagcgca cttctccggg gacgacagca agcgaccgct agacaagagg ggtcgtgcgc
3342721 aggcagaagc gttggtacca cagctgctgg cgttcggcgc caccgatgtt tatgccgccg
3342781 accgggtgcg ctgccaccag acgatggagc cactcgccgc ggaactgaac gtgaccatac
3342841 acaacgagcc caccctgacc gaagagtcct acgccaacaa ccccaaacgc ggccgacacc
3342901 gagtgctgca gatcgtcgag caagtaggca cacccgtgat ctgcacgcag ggcaaggtca
3342961 ttcccgatct gatcacgtgg tggtgcgagc gcgacggtgt gcaccccgac aagtcccgca
3343021 atcgcaaagg cagcacgtgg gtgttgtcgt tgtcagccgg caggcttgtg acagccgacc
3343081 acatcggcgg tgcgctggcc gccaacgtgc gggcctaaca cacggatacc cttcgtcaca
3343141 ttgccaccgt gcaaagggta tccgtgtgtc ttgacctatt tgcgaccccg ccgagcggtt
3343201 gccttcttgg cgggagcctt ggtagccggc cgcttggccg ctgccttctt tgccggcgcc
3343261 ttggtcgccg ccttacgcac cgatgccttg accgcggtct tcttcaccgc cttggtcacc
3343321 ttcttggcgg gtgacttcgt ggccttgaca gctttcttgg cgggcgcctt ggtcgccgct
3343381 ttcttggcgg gcgccttggt cgccgccttc ctggcgggcg ccttggtcgc cgccttcttg
3343441 gcggcctttg tcgccttctt ggcaggtgcc ttcttcgcta ccttcttggc tgcactggcc
3343501 cccacaccac gcttaacagc gggtccttct gccgggagac gctgcgcgcc agacacaacc
3343561 gctttgaatt gcgcgcccgg gcggaacgcc ggcaccgacg tcggcttcac ctttactgtc
3343621 tcgccggtac gcggattgcg ggccactcga gccgcgcggc gacgctgttc gaacacaccg
3343681 aacccggtaa tggtgacgct gtcgcctttg tgtaccgcac gcacaatcgt gtcaacgaca
3343741 ttctcgacgg cggcggtcgc ctgccgacgg tccgagccca atttctgtgt gagcacgtca
3343801 atgagctctg ctttgttcat cccaaccctc cgaaaccagt ggtcctcgtt tggaaccgac
3343861 tagtggacac ggtaaaccct tacccggctg atttccaaga gccacgcgca atttcactga
3343921 gccaacgacc ggtttttcgc aatccggttg ccgcccttga ccggtggcgc ggccccaaaa
3343981 tggctcaggt tctgccggcg ggtcacgctg aaatttcgcc cggttctacg cctcaggggg
3344041 cgggtagagt gcgcggtttc cagtacgcgc acgcaccctc aaaggcctcg atctcgtcga
3344101 gtttccgcag cgtaagggct atatcgtcga gaccttcaag cagccgccac gccgagtggt
3344161 cgtcaatctt gaacggcagc accactgttg ctgcggtgat aattcgatct tgaagattgg
3344221 cagtgatttc caggcccgga ctctgctcaa tgagcttcca caggagttcc acatcgtctt
3344281 gggcaacctc ggccgccagc agcccggcct tgcccgcgtt gccgcggaaa atgtcaccaa
3344341 atcgggatga gataaccacc cggaatccgt agtccatgag cgcccagacc gcatgctctc
3344401 gcgaggatcc ggtgccgaaa tcgggcccgg caaccaggac cgaaccccgg tcaaagggac
3344461 tgaggtttag cacgaatgca ggatccgacc gccaacccgc gaacaagccg tcctcgaaac
3344521 cggttcgggt gacccgcttc agaaagaccg cgggaatgat ctgatcggtg tcgacattgg
3344581 accgccgcaa cggcacgcca ataccagagt gggtgtgaaa ggcttccatg ctgatcccct
3344641 agctgttctc agttcaattc aaatcggccg ggctggacag tgtgccgcga accgcggtgg
3344701 cggccgccac tgctggggac accaaatgtg tgcggccgcc cgcgccctgc cgcccttcga
3344761 agttgcggtt ggacgtcgcg gcgcagcgct ccccggacgc cagctgatcg ggattcatgc
3344821 ccagacacat cgagcatccc gcctgccgcc attgcgcgcc cgcgtcggtg aagatctcac
3344881 cgagcccttc ggcctcggcc tgcgcgcgta cccgcattga gcccggaacg atcagcatcc
3344941 gcacgccgtc ggccaccttg cggccacgca gcacttcggc gaccacccgc agatcttcaa
3345001 tgcgaccgtt ggtacacgac ccgacgaaca cggcgtcgac cgcgatgtcg cgcatcgcgg
3345061 ttccgggtcg aaggtccatg tacgccaatg ctttctcggc ggcctgccgc tcggcgtcgt
3345121 cggtcatcag ttgcggatct ggcaccgcgg ccgccagcgg taccccttgg cctgggttgg
3345181 tgccccaggt gacaaacggg ctcaacgacg cggcgtcgag atacacctcg gtgtcgaaaa
3345241 cggcgccgac gtcggtgcga agccgttgcc agtagacgag tgcggtgtcc cactgggcac
3345301 cggtgggtgc gtgcggacga ccacgcaaga acgcgtaggt ggtttcgtcc ggagccacca
3345361 tgcccgcacg agcgccggct tcgatgctca tgttgcagat cgtcatccgg ccttccatgg
3345421 acagcgattc gatggcgctg ccccggtatt cgatgacatg cccctggccg ccgccggtgc
3345481 cgatcttggc gatcaacgcc aggatgatgt ccttggccga cacaccgtcg ggcagccgcc
3345541 catcgacgtt gaccgccatg gtcttgaacg gccgcagcgg cagcgtctgg gtggccagca
3345601 cgtgctcgac ctccgacgta ccgatgccca tcgccaacgc gccgaatgcg ccgtgggttg
3345661 aggtgtggct atcgccacag acgatcgtca ttcccggctg ggtgagaccc aattgcggtc
3345721 cgacgacgtg cacgatgccc tgctcgatat cgcccattga atgcagccgg attccgaatt
3345781 cggcgcagtt tcggcgcaac gtctccacct gggtgcgtga caccgggtcg gcgatcggct
3345841 ggtcgatgtc gacggtgggc acgttgtgat cctcggtggc gagggtgagc tcgggccgcc
3345901 gcacccggcg cccggccagg cgcaggccgt cgaacgcctg cgggctggtg acctcatgca
3345961 ccagatgcag atcgatgtag atcaagtcgg gcgcacagcc cccgcctgat accacaatgt
3346021 ggtcgtccca aatcttctcg gccagtgtgc gtggctcgcc ggtctgcaag gccatctcga
3346081 agtgcctcta ttcattcgtt cgcgactcgc tggtcatctc aaaatacgag acgctatgat
3346141 ctctttgtga gacagcatag cggtatcggt gtcctcgaca aagccgttgg cgtgctgcac
3346201 gcggtcgcgg aatctccctg cggactggcc gaactctgcg atcgaaccga cctgcccagg
3346261 gccaccgcat accggctggc ggccgcgctg gaggtgcatc gcctgctggg gcgcggccag
3346321 gatggccact ggcggctcgg tccggccatc accgaactcg cgacccatgt cgacgatcca
3346381 ctgctggtgg cgtgcgcggc ggtactgcct cagctgcgcg acgccaccgg cgaaagcgtg
3346441 caggtatatc gccgcgaggg aacgtcgcgg gtctgcgtgg ccgcattgga accagctgcg
3346501 ggccttcgcg atacggtccc ggtcggggca cggttgccga tgaccgcggg ctcgggcgcc
3346561 aaagtgttgc tggcccacac cgacgccgcc acccaagcgg ccgtattgcc aaaggcggtg
3346621 ttcagcgccc gagcgctggc cgaggtgtgc cggcgcggct gggcgcaaag cgtggccgaa
3346681 cgcgagcctg gcgtggcgag cgtgtcggcg ccggtgcgcg acggccgggg cgtcgtgatc
3346741 gctgccatct cggtgtccgg cccgatcgac cggatgggcc gccgcccggg ggtccgatgg
3346801 gccgccgacc tgctgtccgc ggcggacgcg ctcacccgac ggctctagcc gcgttgtgct
3346861 acatcggttc gaccgcgatc acatagtcat tgccgtgcca cagaccgtct tgccgctcgt
3346921 tgagctgcaa tgcccgagcg cgcagttctt ccacataggc acgcattgcc atgccaagcc
3346981 cgttggagga gaatcgctcg attcgggcca agcacatgtt gagttggccg ttcacgtagc
3347041 gagctcggta gcggatgggg aagcggcgcg cttcaagaat gcgaaagccc gcaaggccca
3347101 gtcgccccag catccagtcc agcgggaact ctcggtacgg tcgttcgccg gcaagcaaca
3347161 ggcaggcgtc gcgcacgcga ccgatttccc agatgatttt gccactttcg gtttccggct
3347221 cgaattgcac gtagggctcc aagccgacta ggtaaagacg accatgatcg gcgagatgcg
3347281 ggcgcaaccg ctcgaacacg cggtcctgcc agtacggggc gaagccttcg atggccccga
3347341 ccaggtagtc gaccaagatg gtgtcgaacg tctcgccggc aagaaggctg tcgtctaccc
3347401 agttgccgac gagcaggcgg tcctgcgggc gcatggcgct acccaacgcg gcgcgggtct
3347461 tgtccgccag gctgcgggcg gccgtgaccg ccgtccagcg ctcggtcggc aaagtctgta
3347521 tccactgaag cgatttcaca ccggtaccgg catccaagac agtgccccag ggtctttcgc
3347581 cgtgcacgcc ttcgatgtag cggaacaagg atgagatccc ggccctcagt atgtacgagc
3347641 gaccgtggcg ggcgtgtagg tcttcgatgt ggcggatcag ggctgcgatc ttgggcattt
3347701 cggcccaggt cacacacatc gcagacgtcc atgcggccgg ttcggccgag cgcggtatcg
3347761 cggcgccggc ttcagaccct gccaaccgag cgatcgtcgt gggtgcttcc tcggagtaac
3347821 cactgtgatg tcttcctcac ggctgaagct ggcggactac cgatgaaccg acccaccgaa
3347881 actctatagc aaacgatatt cattttcaaa ctaggcaccg cgagcgtcac tggggtggcg
3347941 acgacgcgct accggcggag ccttgctgac acactgacgc catgggaacc aaacagcgcg
3348001 ccgacatcgt catgtccgag gctgaaatcg ccgacttcgt caactcgagc cgtaccggaa
3348061 cgctggccac catcggaccc gacggccagc cgcacttgac ggcgatgtgg tatgccgtga
3348121 tcgacggcga aatctggctg gagaccaagg ccaagtcgca gaaggccgtc aacctccgac
3348181 gggatccgcg ggtgagcttc ctgcttgaag acggcgacac ctacgacacg ctgcgcggcg
3348241 tgtcgttcga gggcgttgcc gagatcgtcg aggagcccga ggcgctgcac cgcgtcgggg
3348301 tcagcgtgtg ggaacgctac accggcccct acaccgacga gtgcaaaccg atggtcgacc
3348361 agatgatgaa caagcgggtc ggtgtgcgca tcgtggcccg tcggacccgc tcgtgggatc
3348421 accgcaagct ggggctgcca cacatgtcgg tgggtggctc gaccgccccg tagctgcccg
3348481 gcgagcagac gcaaaatcgc ccatttcgag acgaaattgg gcgattttgc gtctgctcgg
3348541 cagttgtagc cccgatggga ttcgaaccca cgctaccgcc gtgagagggc ggcgtcctag
3348601 gccgctagac gacggggccg gaaccgatcc gagctgccag catagctcac gccttgtgct
3348661 ggggtaccag gactcgaacc tagaatggct gaaccagaat cagctgtgtt gccaattaca
3348721 ccatacccca tgggctgcct aaaaccgctg ccgccagctg ttatgggccg acgtgcagac
3348781 taccaaagat tcgccacaca aggctcacgc gtgcccgacc agctggcgcg ccgcgcgcag
3348841 ccgctgcatg ctgcggtcac gaccgagcag ctccagcgat tcaaacaacg gcgggctgac
3348901 ggtcgtgccg gtggcggcca cccggatggg gctgaacgcc ttgcggggtt tgagcgccaa
3348961 accttcgatc aaggcgtcct taagggccgc ctcgatcagg ggtgccgtcc agtccgtcac
3349021 acttgtcagc gcggccaggg ccgcgtcgag caccgcggcc ccgtctgggc ctagctcctt
3349081 ggccgcggcc ttgggatcga tcacatactg atcgtcgttg aagaacttca acagctccca
3349141 cgcgtcaccg agcaccacga tgcgggtctg caccaactcg gcggcggcgg cgaatgccgc
3349201 ctcatccaac gcgatgtgat ggccgtgggt atccagatgg tcgcgcagcc tgaccgtgaa
3349261 gtcgcccacg tcgagcatcc ggatgtgctc ggcgttcagc gcgtcggcct tcttctggtc
3349321 gaaccgggcc gggctggagt tgacgtcggc aacgtcgaac gcggccacca tctcgtcgag
3349381 accgaacagg tcgtggtcgt cggctatgga ccagccgagc aacgcgaggt agttcagcag
3349441 gccttcgggg atgaacccgc ggtcgcggtg ggcaaacagg ttcgactgcg gatcgcgctt
3349501 cgagagcttc ttggtgccct cccccaagac cgttgggagg tgcgcgaatt tcggaatccg
3349561 ctcagctacc ccgatcctga tcaacgcctg atgtagcgcc agctggcgcg gcgtcgacgg
3349621 cagcaggtcc tcgccacgca acacatgggt gatcttcatc agcgcgtcgt cgcacgggtt
3349681 gaccaaggtg tataacggat caccgctggc tcgggtcaac gcgaagtcgg gtacggagcc
3349741 agccgcgaac gtcacgggcc cgcgcaccag gtcattccaa gcgaggtcgt catcgggcat
3349801 ccgcagccgc accaccggct ggcggccctc cgccaggtac gccgcacgct gcgcgtcggt
3349861 caagtgacga tcgaaattgt cgtaacccag cttgggattg cgcccggccg cgacatgacg
3349921 ggcctccact tcctcgggtg tggagaaagc gtggtaggcc tcgcccgcgg cgagcagtcg
3349981 ggcgagcacg tcacggtaga tttcggcgcg ctgcgactgc cggtacggcc cgtacggccc
3350041 acccacctcg ggcccctcat cccaatccag gccaagccag cgcagcgcgt ccagcagcgc
3350101 cagatagctt tcctcgctgt cgcgttgggc gtcggtgtcc tcgatgcgga acacgaaggt
3350161 gccaccggtg tgccgggcgt aggcccagtt gaacagcgcg gtgcggacca gaccgacgtg
3350221 cggagttccg gtgggtgaag ggcagaatcg gacccggact gtttccgtgg cggtcacggc
3350281 tttcctttgc ggactacggg attggtgagg gtgccgattc cctcgatggt gatcgagacg
3350341 gtgtcgccgt cctcgatggg accgactccc gcgggtgtgc cggtgaggat gagatcacct
3350401 ggcagcaagg tcattatcgc cgagatccat tccacgatgg cgccgatgtc atggatcatc
3350461 agcgaggtgc gggcgtgctg tttgacgtcg ccgttgacga cggtgcgcag ctcgagatcg
3350521 gccgggtcaa agggagcgag gtcggtgacg atccacggcc cgaccgggca gaaggtgtcg
3350581 tgccccttgg ctcgcgtcca ctgaccgtcg gattgctgct gatcgcgggc cgacacgtca
3350641 ttgccgatgg tgtagccgag gatattgtcg acggcctggg cggccgggac atccttgcac
3350701 gcccggccga tcacgatcgc cagctcaccc tcgaagtgca ccggtgatgc gttggcgggc
3350761 aatcgaattg gcgtattcgg accgatgatc gcggtgttgg gcttgaggaa tatcaccggg
3350821 tctgccggcg gccggccacc catttcggcg atgtgatcgg catagttctt cccgacacag
3350881 accaccttgc tcgccagtat cggagccagc aggcgaacgt cggccagcgg ccaggagcgt
3350941 ccggtgaagg tcggcgtacc gaacgggtgc tcggcgatct cgcgggccgt catctcactc
3351001 ggctcgccca gctcgccgtc gatgctggca aaagcgacac cgtccgggct ggcgattcga
3351061 ccgatacgca tttggatgag cttagccggg ccctgccggg cgacgattcg ggccggcacg
3351121 gcccgatgag gagcccggca atcagaccct gccgggcgac gattcgggcc ggcacggccc
3351181 gatgaggagc ccggcaatca gaccctgccg ggcgctgcgg gccctcacca tcgggccccg
3351241 tgccgggtga ctgtgccagc atgggtggat gtcgcgagat ccgactgggg tgggtgcgcg
3351301 ctgggcgatc atgatcgtct cgctgggggt gaccgcaagc tcgtttctct tcatcaacgg
3351361 tgtcgcgttc ttgatccccc ggctggaaaa tgcgcgcgga accccgctat ctcacgcggg
3351421 tctgttggcg tcgatgccca gctggggcct ggtggtcacg atgttcgcct ggggctatct
3351481 gctcgatcac gtcggcgaac ggatggtgat ggccgtgggc tcggcgctga ccgccgcggc
3351541 cgcctacgcc gcggcatcgg ttcattcgct gctgtggatc ggtgtcttcc tgtttctcgg
3351601 cggcatggcc gccggtggtt gcaacagcgc cggcgggcgg ctggtctcgg gttggttccc
3351661 gccccagcaa cgcggtctgg ccatgggaat ccgccagacc gcacaacctt tgggcatcgc
3351721 ctccggcgcg ttggtgatac ccgaactggc cgaacgcggg gtgcacgcag ggctgatgtt
3351781 tcccgccgtc gtgtgcacgt tggccgcggt ggccagcgtg ctcggtatcg tcgacccacc
3351841 gcgaaaatcc cgcacgaaag cctccgaaca ggagctggcc agcccttatc ggggatcgtc
3351901 gatcctgtgg cggatacacg cggcgtcggc gttgctgatg atgccgcaga cggtgaccgt
3351961 gacgttcatg ttggtctggc tgatcaacca ccacggctgg tcggtcgcgc aggccggtgt
3352021 cttggtgacc atatcgcagc tgctgggggc gctgggccgg gtcgcggtcg gccgctggtc
3352081 ggaccatgtc gggtcacgca tgcgtcccgt ccgcctgatc gccgctgccg ccgcggcgac
3352141 gttgtttctg ctcgcggcgg tcgataacga gggctcgaga tatgacgtgc tgctcatgat
3352201 cgccatctcg gtgatcgccg ttctggacaa cgggctagaa gccaccgcga tcaccgagta
3352261 cgccggaccg tactggagtg gccgggcgct gggtatccag aacactacgc agcggctgat
3352321 ggcggccgcc ggacccccac tgttcggtag tttgatcacc acggcggcct acccgacggc
3352381 atgggcctta tgcggtgtgt tcccgctggc cgcggtgccg ctggtgccgg ttcggctgct
3352441 cccacccggc ttggagacta gagcgcggcg gcaatccgtt cgccgacatc gctggtggca
3352501 agccgttcgc tgccacgcgt ggccaaatgg gcctcgacgg cccggtccac ccgggcagcc
3352561 gcgtcgtgtt cgccaaggtg ggacagcaat aacgccaccg acatgatcgc cgccgtcggg
3352621 tcggcgatgc cctgaccggc gatgtccggc gcgctgccat gcaccggctc gaacatcgac
3352681 gggttggccc gggtcgcgtc gatattccca ctggccgcca agccgatacc gccacatacc
3352741 gccgcggcca gatcggtgat gatgtcgccg aacaggttgt cggtgacgat cacgtcgaag
3352801 cgacccgggt cggtgatcat gtggatggtg gcggcgtcga cgtgctggta ggccacctcg
3352861 acgtccgggt agcattcgcc gacctcgtcg acggtccgca accacaatcc cccggcgaag
3352921 gtcaacacgt tcgttttgtg caccaatgtc agatgcttgc gacgccgtcg agcccgctcg
3352981 aacgcgtcgg caaccacacg ccgcacaccg aacgcggtgt tcacgctgac ttcggtggcc
3353041 acctcgttgg gcgtgccgac gcgaatcgcc ccgccgttgc cggtgtaggg tccctcggtg
3353101 ccctcgcgca ccaccacgaa gtcgatgccg ggattgccgg acagcgggct ggccaccccc
3353161 ggatacagcc gggccggacg caggttgatg tggtgatcca gctcgaagcg cagtcgcagc
3353221 aacagaccgc gctccaagac gccgcttggc accgacgggt caccgatcgc cccgagcagg
3353281 atcgcgtcgt ggttgcgcag ctcggccacc accgagtccg gcagcacctc gccggtggca
3353341 tgaaagcgcc gcgcacccag gtcatagctg gttttctgga cgcccggcac aaccgcgtcg
3353401 agcactttga ccgcctcggc ggttacctcg ggcccgatcc cgtcaccggc aatgatcgcg
3353461 agtttcatcg gcgtggaagg gctcacgaca gatcgacaac ctcgagcttg taggcgtcca
3353521 ccgccgccgc gatcgccgtc cgcacgtcgt cgggcacgtc ttggtccagc cgcagcagaa
3353581 tcgtcgcgcc cgggccttcg gcgtcttcgg agagctgcgc ggcctggata ttcaccccgg
3353641 ccgtccccag caacgtgccg atcttgccca gcgctcccgg ccggtcgacg tagtggatga
3353701 tcaggttgat cccctgggcg cgcagatcaa agtggcggcc gttgatctgc acgatcttct
3353761 gcgacagctg tgggccatac agcgtgcccg agacggtcac caccgaaccg tccgcgccga
3353821 ccgcgcgaac gtcgacgacg ctgcggtggt tggggctttc cgaggcctta cagatctcgg
3353881 cggtgacgcc acgttcggcg gccaatgccg gtgcgttgac aaatgtcacc gcatcctcga
3353941 tcaccgccga gaacaggccg cgcagcgccg aaaggcgcag cacctcaacc tcttcggcgg
3354001 ccagctcacc gcgcacctgc accgacaacg acaccggcag ttcgtcggac aacacacccg
3354061 ccagcacgcc gagcttacgc accagatcca gccagggcgc cacctcctcg ttgaccactc
3354121 cgccgccgac gttgaccgcg tcgggcacga attcccctgc cagggccagc cgcacgctct
3354181 cggcgacgtc ggtgcccgcc cggtcctgcg cctccgcggt ggacgcaccc agatgcggtg
3354241 tgaccaccac ctgtgccagc tcgaacagcg ggctgtcggt gcacggttcg gtggcgaaca
3354301 cgtccagacc ggccgcccgc acgtggccgc cggtgatcgc gtcggccagt gccgcctcgt
3354361 ccaccaggcc gccgcgcgcg gcgttgacga tgatgacgcc cggcttggtc ttcgccagcg
3354421 cctccttgtc gatcagtccc gccgtctccg gtgttttcgg taggtgcacc gagatgaaat
3354481 cggcgcgggc cagcaggtcg tccagggaca gcagttcgat gcccagctgc gccgcacggg
3354541 ccggcgaaac gtacgggtca taggcgacga cgtaagcgcc gaacgcagcg atccgctggg
3354601 cgaccaactg cccgatgcgg cccagaccca ccacgccgac ggttttgccg aagatctcgg
3354661 taccggaaaa cgacgaacgc ttccaggtgt gctcgcgcag cgacgcgtcg gccgccggaa
3354721 tctggcgtga ggcggccagc agcagcgcca gcgcatgctc cgcggcgctg tggatgttcg
3354781 acgtcggggc gttgaccacc agcacgccgc gggccgtcgc ggcgtccacg tcgacgttgt
3354841 ccagcccgac gccggcgcgc gcgacgatct tgagcttggg ggcggcggcc agcacctcgg
3354901 cgtcaaccgt ggtggccgat cgcaccagca gcgcgtccgc ttcgggcacc gcggccagca
3354961 gcttgtctcg gtccggaccg tcaacccagc gcacctcgac ctgatctccc aaggcggcaa
3355021 ccgttgatgg ggcaagtttg tcggcgatca acacaacagg caggctcacg ccgatagcgt
3355081 atcggctgta attgacgagt ggacgtcacc gtcgtcggca gcggacccaa cgggctcgcc
3355141 acggccgtca tctgcgcccg cgcgggcctg aacgtgcagg tcgtcgaggc ccaggcgacc
3355201 ttcggcggcg gcgcccgcag cgcggccgac ttcgaatttc ccgaagtttt acacgacgtg
3355261 tgctccgcgg tgcatccgct tgctttggcg tcgccgtttt tcgccgaatt cgacctaccc
3355321 gcgcgcggag tgacgctgac cgtgcccgac atcgcctacg ccaacccgct acccgggcgg
3355381 cccgcggcga tcgcctatca cgatctggcg cacacctgcg ccaagctgga cgacggcgcg
3355441 tcctggcggc gcctgctggg cccgttggtg gcgcactcgg agacggtcgt ggagttcatg
3355501 ctctccgaca agcggtcttt gcctactgca ctgggctcgg tcctgcgtct cgggctgcgg
3355561 atgctggccc agggcacccc tgcctggcgg tcgctggcgg gcgaggatgc ccgcgcgttg
3355621 ttcaccggcg ttgccgccca cgcgatttca ccgttgccgt cactggtgtc ggccggcgcc
3355681 ggactgatgc tggcaacgct ggcccattcg gtcggctggc cgattccggt gggcggcacc
3355741 caggcgatag ccgacgcgct gatcgccgat ctacgcgcgc atggtggtcg gctcgcggcc
3355801 ggtgtcgaga tcaccgaacc gcaaagaagt gtggtcgtct tcgacaccgc acccaccgcc
3355861 ctgctgcggg tttaccgcga caagcttcca catcggtatg ccaaagcatt gcgccgctat
3355921 cgatttcgcg ctggcatcgc caaggtggac ttcgtgctca gcgacgagat cccgtggtcg
3355981 gatccgcggc tgcggcgggc tgcgaccctg catctcggcg gcacccgtga ccagatggcg
3356041 cgcgccgagg cagacgtcgc ggcgggacgc cacgccgact ggccgatggt gctggccgcg
3356101 tgtccgcacg tcgccgaccc cggccgcatc gacgaaaccg gccgccgtcc gttctggacc
3356161 tatgcccacg tgccgtcggg gtccacgctc gacgcgaccg agaccgtaac cagcgtcctc
3356221 gagcggttcg cccccggctt ccgtgacatc gtggtggcgg cccgcgccgt gcccgccgcg
3356281 cggatggccg accacaacgc caactacgtc ggcggtgaca tcacggtcgg cgccaactcg
3356341 acctggcgcg cgatcgccgg ccccaccccg cggttgaatc cctggcgcac accgattccc
3356401 aaggtgtacc tgtgttctgc ggcgactccg cccggcgccg gcgtgcacgg catgtgcggc
3356461 tggtatgccg ctcgaacgct gttgcgcacc gagttcggca tcacccgcat gccccctttg
3356521 ggccatgagc tgaggccata acgaagcttg cgatcatcga ctattcggag gcgcgccagg
3356581 cggcagcggc gacaaccgga acgtcggcac ggtgctcaat cacgggtgca cggtgtgcat
3356641 cagaatggcg ggggttcgtt gtcgcggtga ggcgttcggc gaggaggtag tgtctacccc
3356701 ttgcccgcgg gttcgtgcgg actgaaggga tttcattggg aacccacggc tgcgtatcgc
3356761 agggcctcgg tgacgtctgc ttcctcaagc tcaggaagtt cggcgagaat ctcggtggat
3356821 gtcatttggt ccgcgaccat cgcgaccaca gtcgccactg ggatgcgcaa gccccggatg
3356881 catggcatgc ctcccatcac gtcggggtcg atggtgacgc gggtgactcg catgtctata
3356941 aggctagccg gtgacagcac gctggggcgg ttctccacca gccgtcttgg cttaagctca
3357001 gccaagagca agccggaggg agatttcggc accgcctgcg gcgcggtttc gggcggtgac
3357061 gctggcgtgg ttgcgttggc tgagggtgtc gacgatggcc agtccaagcc cggtgccgcc
3357121 ggtggtgcgc gcggtgtcgg tggtttccgc gagagccgag cggattgcgg cgagcagttc
3357181 ggggttgctt cgtggacgcc gcagggcgag ttcgagttcg gtggtcagga ggctaagggg
3357241 gtgcgaagtt cgtggcccgc atcgctgacg aattgacgtt ctcgctcgag cgcgtcttgc
3357301 agccgctgca gaaggtcgtt gaatgttgtt ccaagatacc ggatttcgtc tcgagccagt
3357361 ggcaatggca gacgggcatg tgggtcggtg gcgctgatgc ccgcggcgcg gatgcgcatg
3357421 cgttccacgg gtcgaagagc cgcggcggcc agcagatacg cgcccagggc gtcgatgagg
3357481 acgtctggcc gtgcccggat cggtgcgatc gagcttcatc gtggtttcat aatcacccga
3357541 tagaccatgg ctaaccgaac tgccatccac gccgtggatg caacggatgg agggaacgcg
3357601 catggcgggc gccaaacatg ctgggagaat cgtcgcgatc accaccgcgg cggcggtgat
3357661 actggcggcg tgcagttcgg gctccaaggg tggagcgggc agcggccacg ccggcaaagc
3357721 tcgttcggcg gtgaccacca ccgatgccga ctggaagccg gtggccgacg cgctgggacg
3357781 tagcggcaag ctcggagaca acaacaccgc gtatcggatc aacctgccgc gcaatgacct
3357841 tcacatcacg tcctacggtg tggacatcaa accggggctg tcgttgggcg ggtacgcggc
3357901 attcgcccga tacgacaaca acgaaacgct gctgatgggc gacctcgtga tcaccgagga
3357961 ggagttgccc aaggtcaccg atgcgttgca ggcgcatggt atcgcccaga ccgcactgca
3358021 caagcatctg ctgcagcaag acccgccggt gtggtggacc cacattcacg gcatgggtga
3358081 tgccgcccga ctggcccaag gactcaaggc ggcgttggat gccacaacga tcggcccgcc
3358141 taccccaccg ccggcacggc aaccaccggt cgacatcgac gtcgccggcg tcgaccaggc
3358201 gttgggccgc aagggaaccc aagatggtgg gctgatgaag tacagcatcc cccgcaaaga
3358261 caccatcatc gaggacgggc acgtgctgcc cgcagtgtcg ctgaacctga cgacggtgat
3358321 caattttcag ccggtgggcc gcggtcgcgc agcgatcaac ggcgatttca tcctgatcgc
3358381 ccccgaggtt caggaggtca tccgggcaat gcgtgccggc aacatcacga tcgtggaact
3358441 gcacaaccat gggctgaccg aagagccccg cctgttctac atgcattact gggccgtcga
3358501 cgacgcggtc accctggcgc gggcgctgcg cccggcgatg gatgccacca acctgcagtc
3358561 gtcataatcc cgatgcaacc gcataagggc tggtgtggct gatgcatcct gatggcggtg
3358621 catggtttcc tgctcgaacg ggtcagcgtg gtgcgcgacg aggcgacggt gctgcggcag
3358681 gtcagcgcgc attttcccgc tggccgctgc agtgcggtgc ggggcgccag tggatcggga
3358741 aagaccacgc tgctgcggtt gctgaaccgg ctcatcgatc cgacgtccgg aaaagtctgg
3358801 cttgacggtg tgccgctcac cgatctggat gtgctcgtgt tacgtcggcg ggtcggcctg
3358861 gttgcgcagg ctcccgtggt gcttaccgat gcggtgctca atgaggttcg cgtcggacgc
3358921 ccggacctgc cagaaggtcg agtgaccgag ctgctggcgc ggctgtgtct cggccagtcc
3358981 gcacgcgaag cgttcttgcc gcaccaacga tccgccttgc gcactgcgct gatacccgcg
3359041 atcgactcca cgaaagtcgt tgggctgatt agccttccgg gtgcgatgtc cggacttatc
3359101 ctggccgggg tcgacccgct gaccgcgatc cgctaccaaa tcgtggtgat gtacctgctg
3359161 ctcgccgcca ccgcggtggc agcgctgacc tgtgcacgcc tggctgaacg tgccttattc
3359221 gaccgcgcgc accggctcgt ttcgctgccc gcggcgactc gtcgggcatg agttcgcgac
3359281 tcgatcacag ccaatcgccg ctgtggcatg tggccgttgt cagtcgttat ccacggtctc
3359341 cgtgcccagg aagcgaaagc cctgatccag gtgcacttcc acctgagtac catcgggttt
3359401 ggtgacgagc accctcatcg cttcatccct tcttgtcgtc gtcgtggtta cgaaggcgac
3359461 gctaacggcg ccagatgaag ccccgatgaa ggcagcgacg ccggtgacac aacggggcgg
3359521 acctgccccg tggcacacgg cggttgccgg tcacgatcac tgcagtgtcg agacggccta
3359581 ggagctaggc cgtctcggtg atcgggcggt ccacccagct catcaggtcg cggagtttct
3359641 tgccgacgac ctcgatgggg tgctcggcgt tttgccggcg caactcttcg agctgtttgt
3359701 tgccgccctc gacgtcggcg accagcttgt ggacaaagct accgtcctgg atctcccgca
3359761 ggatgtcgcg catccgctcc ttggtgccgg catcgatgac gcgcgggcct gagaggtagc
3359821 cgccgaattc cgcggtgtcc gacaccgagt agtacatccg cgccaggcca ccctcgtaca
3359881 tcaagtcgac gatcagcttc agctcgtgca gcacctcgaa gtaggccaat tccgcggggt
3359941 agccggcttc gaccatgacc tcgaacccgg ccttgaccaa ttcctcggtg ccgccgcaca
3360001 acaccgtttg ctcaccgaac aggtcggttt cggtctcgtc tttgaacgtc gtcttgatga
3360061 cgccggcccg ggtgccgccg atcgctttgg catacgacag cgccagcgcc aagccgtcgc
3360121 ctcgcggatc ctgctctacc gcaaccaaac acggcacacc cttgccgtcg acgaactggc
3360181 ggcgcaccaa atgacccggt cccttcgggg cgaccatcgc gacggcgacg tcggcgggcg
3360241 gcttgatcaa gccgaagtga acgttgagtc cgtgaccgaa gaacagcgcg tcaccgggct
3360301 tgaggttggg ttcgatgtct cctgcgaaga tctcggcctg ggcggtgtcg ggggccaaca
3360361 ccatgaccac atcggcccat ttggcgacct cggcgggagt gtcgacgtcc aggccctgct
3360421 cttctacctt gggccgcgac cgcgaaccct gcttcagccc gacgcgcacc tgcacacccg
3360481 agtcgcgcag gcttagcgag tgcgcgtgcc cctggctgcc gtagccgatc acaccaacct
3360541 tgcggccctg aatgatcgac aggtctgcgt cgtcgtcgta gaacatctct agtgccaccg
3360601 ctgaatctct ccttacctgc tagctacttg gcggtgccga tgccgcgcgg accgcgggac
3360661 agcgacacca ttccggattg ggcgatttcg cgaataccga acggctccaa cacccgcagc
3360721 agggcctcta acttgccgcg gttaccggtg gcctcgacgg tcaatgactc cggggatacg
3360781 tcaatcacgt tggcgcgaaa cagattcacc gcttcgatca cttggctgcg gctgccggcg
3360841 tcggcttgga ccttgatgag cgccaattcc cgtgacaccg agtgctcgtc gtcctgctcg
3360901 acgatcttga tgacgttgat cagcttgttg agctgcttgg tgatctgctc gagcggagtg
3360961 tcctcggcgg agaccacgat ggtcatccgt gacctgtcct tgcactcggt ggcacccacc
3361021 gccaacgact cgatgttgaa accgcgccgg gagaacagcg ccgccacccg cgccagcacg
3361081 ccgggcttgt cttcgaccaa caccgacaac gtgtgcgtct tcgggctcat caggcgtggc
3361141 cttcggtgat gtcgtcgaac agggggcgaa tgccgcgggc ggcctggatc tcgtcattgc
3361201 tggtgcccgc ggccaccatc ggccacactt gcgcgtcggc accgacgatg aagtcgatca
3361261 ccaccgggca gtcgttgatc gcccgcgcct ggttgatgac gtcgacgacg tcctcttccc
3361321 gctcgcaccg caaccccaca caccccaagg cctcggccag tttcacgaag tcggggatgc
3361381 ggtgcgaatg agtggccagg tcggtctgcg agtaccgctc ggcatagaac aggctctgcc
3361441 actgccgcac catgcccagg ttgccgttgt tgatcagcgc caccttgacc ggtatgccct
3361501 cgaccgcgca ggtggccagc tcctggttgg tcatctggaa gcaaccgtcg ccgtcgatcg
3361561 cccagacctc ggtgccgggg agggcgatct tggcgcccat ggccgccggg atggcaaacc
3361621 ccatggtgcc cagaccgccg gagttcagcc agctgcgcgg cttttcgtat ctgatgaact
3361681 gcgcggccca catctggtgc tggccgacgc cggcgacgaa gacggcgtcc ggcccggcga
3361741 tctcgccgag cttttcgatc acgtattccg ggctcaggct gccgtcgctc tgcggcccat
3361801 agctcagcgg ataggtcttg cgcacaccgt tcaggtatgc ccaccagtcg gccatctcga
3361861 tggtgccggg aatgtggtgg tggcgcagca tcgcgatcag ttcggtgatg acggccttga
3361921 cgtcaccgac gatgggcacg tcggcgtggc ggttcttgcc gatctcggcc gggtcgatgt
3361981 cggcgtggat gaccttggct tccggcgcga acgagtcgag cttgccggtc acccggtcgt
3362041 cgaagcgggt acccagcgcg atcagcaggt cgctgcgctg cagcgccgcc acggcggcca
3362101 ccgtgccgtg catgccgggc atgccgaggt tttgccggtg gctgtcggga aacgcgccgc
3362161 gggccatcag cgtggtgacc accgggatgc cggtcagctc ggccagctcc cggagctgct
3362221 cggtggcctc accgcggatg acgccgccgc cgacatacag caccggcttg cgcgcggccg
3362281 cgatcagctt ggcggcctcg cggacctgcc ggctgtgcgg tttggtgttg ggcttgtagc
3362341 cgggcagctc catccgcggc ggccagctga acgtgcactg gccctgcagc acgtccttgg
3362401 ggatgtcgac cagcaccgcg cccggacggc cggaggccgc gatgtggaag gcctcggcca
3362461 gcacccgcgg aatgtcgtca ccggagcgga ccagaaagtt gtgcttggtg atcggcatcg
3362521 tgatgcccga gatgtcggcc tcctggaagg cgtcggtgcc gatcagcccc cgcccgacct
3362581 gaccggtgat agcgaccacc gggatcgagt ccatctgcgc gtcggccagc ggggtcacca
3362641 ggttggtcgc tccgggaccc gacgttgcca tgcacacgcc cacccggccg gtgacgtgcg
3362701 cgtagccgct ggcggcatgc ccggcgccct gttcgtggcg gaccagcacg tggcgcagct
3362761 ttttcgagtc gaacagcggg tcatacaccg gcagcaccgc accgcccgga atcccgaaaa
3362821 tgacgtcgac gccgagttcc tccagcgacc ggatgaccgc ctgtgcaccg gtaagctgct
3362881 gcagtgcaac atgtttcgga cgagccgccg ggtgctttgg ctcattcgcc gcgctgtgtg
3362941 gctctggctt gaatgtcggt gagtgtggct tggttggtgc gctcactgtt gtgtgatcct
3363001 ctattgctct ggaagtctcg ttggtggaca agaaaaaacc ctcgccagct cagctgctgc
3363061 acgagggtcg cgttggtgct cgcttgggct agtcaggcac caacgcgccg accaattact
3363121 acgagcatcc cgggctttcc ggccttgtcc atagtgtccg acggtagcct tcacacagct
3363181 cagcagtcaa atccgcggtg tcagtcttga tccgcgagcg tgacggcact gcgaaatccc
3363241 atgcgaattt tcgcggtggc gttacgctcg cgaactcgac gcccaccaag cggtgagatg
3363301 atgctggggt ggccaccaca tcgccggtcg tgatcaaagt gtcgccgatg gcgcacttcg
3363361 ccgtgggatt cctgaccctg ggtctgctgg tgccggtact gacctggccg gtgagcgccc
3363421 cgctgttagt cattccggtg gcgttgtcgg catcgatcat tcggctccgc acgctcgccg
3363481 acgagcgggg cgtgaccgtg cggacgctgg tcggcagccg cgcggtgcgc tgggacgaca
3363541 tcgacgggct gcggttccac cgcgggtcct gggcgcgcgc aacgctcaag gacggtaccg
3363601 agctgcgatt gcccgcggtg acctttgcga cgctgccgca cctgaccgaa gccagctcgg
3363661 gacgggtccc caacccgtac cgatgacagc gttcaggcca gcggatttgc cccgttgagc
3363721 agcacccata cggcaatacc cgccgcgatg ccacccaaca gcgctacaaa cgatccgata
3363781 aatggccgat gagcccagcc gcgggccgcg tccagaccgt agcggccggg accactcaag
3363841 ataacggcga ccgccatcac gaccagggtg atctggtatt catgcccgtc ctgcaggaag
3363901 tacgcgacgg gccgcgaatg ctgtgccgag atgccggcga gcaggccgtt gatcaagaag
3363961 gccagcgcgc ccgcggccgc cagcggagta aacaaaccca acaccagcag cactccggcg
3364021 acgatctcgc cgccagcgct cacataagcg aggatctcgg cgtgctggta accaatgtcg
3364081 gacagcgagt tctggaatcc ggccagaccc tggccgtccc accagccgaa caatttctgc
3364141 agcccatggg cgataaggac cgcgcccaga ccgacccgca atatcagcag cccgagattc
3364201 tgggtgccgc gccgacctgc ggcgcgtacc cgctcgtcgt cgtccatgtc gattccggca
3364261 gatcccgccg gtacctgccg gcccggctgc ggctggacgt agggcaacgg ctccgcagct
3364321 tcgatcaggc tgtacccgga gttgccgaca ccagagctag cggcatcata gggcgggata
3364381 acggtggtgg ttccactgcc aaagtccccg gcatatctgg ccggcgtcag gtcatcctcg
3364441 gggtcgacca ggcttgccga gacaggccgt ccaggcattg gcccaggcga atcatccggc
3364501 cgctgccaat gtgagtcatt cgaactggtc actcgtgtca gggtaaggcc atttagtgcc
3364561 gaattgggga tttgagcggc gctttcgcca gacaatccgc acattgaccc tgaccagccc
3364621 accaaaaggc cccaattggg ccgccatgcc gacagtgcgc accccggcag gtggcggcga
3364681 tgcccacaat gtccgtagcc tgtcggtcat gtggacaacg cggttggttc gatccggact
3364741 cgccgcgctg tgcgcggcag tgctggtatc gagcggctgc gcacggttca acgacgctca
3364801 atctcagccg ttcaccaccg aaccggagct gcggccccaa cccagctcga cacctccccc
3364861 cccgccgccg ctgccgccgg ttccctttcc caaggaatgt ccggcgccgg gcgtgatgca
3364921 aggctgcctt gagagcacca gcggcttgat catgggcatc gacagcaaga ccgcactggt
3364981 cgccgagcgc atcaccggtg ccgtcgagga gatctctatc agcgccgagc cgaaggtaaa
3365041 gacggtcatc cccgtggatc ctgccggtga cggtggcttg atggacattg tgctgtcgcc
3365101 cacctactcg caagaccggc tgatgtacgc ctacatcagc acgcccaccg acaaccgggt
3365161 ggtgcgagtg gccgacggcg acatccccaa ggacatcctg accggcatcc ccaaaggtgc
3365221 tgccggtaac accggggcgc tgatcttcac cagtcccacc acgctggtcg tgatgaccgg
3365281 ggatgctggc gacccggcgt tggccgccga tccccaatcg ttggccggta aggtcctgcg
3365341 tatcgaacag cccaccacca tcggccagac gccgccgacg acggcgctgt ctggcatcgg
3365401 ctccggcggc ggcttgtgca tcgatccggt cgacggctcg ctatatgtcg ccgaccgcac
3365461 gccaacggcg gaccgattgc agcgcatcac caagaactcg gaggtctcta cggtatggac
3365521 ctggccggac aagcccggcg tggccgggtg tgccgcgatg gacggcaccg tgctggtcaa
3365581 cctgattaat accaaactga cggtggcggt ccggctcgcg ccgtcgaccg gtgcggtcac
3365641 cggagaaccc gacgttgtcc gcaaagacac tcatgcgcat gcgtgggcat tacggatgtc
3365701 gccggacggc aacgtctggg gagccaccgt caacaagacc gccggcgacg ccgagaagct
3365761 cgacgatgtg gtgttcccgc tgttcccgca gggtggcggc ttcccgcgca acaacgacga
3365821 caagacctga cccggttagg gcacgtcgag cgtgaacctt acgacgccgt atcggcgtgt
3365881 ctcgtcgccc cgttcacgct cgtagaaccg gggtgaggct tccttgccag ggtcgatgtc
3365941 gtcgacatca aagtcgaggt cggagaggta gagcagatct tccgagcact ccggagccca
3366001 cacgctcacg ggctccaaca ggtaagccac ataatccccg acatcgctgc gactggccgt
3366061 cctaccgatg aaccaggcgg ccgcgtcgtc gagaatcggc attccacagg ggccagcgcg
3366121 ccacgagcaa cgggcgaact tgttgacctc ctcctccgtt tggctgccga acagttcggc
3366181 gagcacatgc tgccgctgcg aaagcacgtg cacggcgagg tgctcggatc ggctcgccac
3366241 ctcggaggtg ccggtgctcc tcggcaggcc gaccataaaa ctcgggggct gcacgctcgt
3366301 ttgggtagcg aagctgacca gacaacccgc ggggtgacca tcggcctggg ttgtcaccac
3366361 aaacaccggg tggtccagca tccccatcaa ctcgtcgaac gactcatcga tcacatcacc
3366421 atcatgaatc cgcgcaacgt cttctgacac tctttccgag cgttcagtcg gcgaatcgcc
3366481 gctaccgcca tcacgtcgac cggtgaggcc gccgtcacgg ccccaaatcg gcgacgatct
3366541 gggcacggaa tcagaacctg attgggtccc ggccagcctc gctggcgtgg gaagtcacca
3366601 cggtcgcgcc gcggcttctc aacccggccg acacgcgctc ccgatgctca ctgtcgtcgc
3366661 tgtcataggc atactcgaat gtggattagt gctacacatg cctgacaacg atttgtggta
3366721 ctgcgggcca tggacactat gggtgatggc cggtaggggt gttgcgtcgg gcgcgggagt
3366781 gtggcgaggt gatcgcgttg cgacgcccct tgcggtggcg attaccgcag ccggattggt
3366841 atcaggggcc cggataggac ccggtgcggc tgcgaaacgc gacccgcagc tcgcacagtg
3366901 gaacgagatt cgcagtcact accaagagat cgccgagtgg atcgaccacg acacagcaac
3366961 cgcacacccc gctgttgccg caacgcagat cagtgccgct ggctctttcg gccgcgccaa
3367021 tatggtcgac tacctggggc tcctggattc cagggccgac gaaacggtcc gacgcgacga
3367081 attttcgcgg tggctgtcgg ccaaacccga ctacttggtc accaccgagc aatctgtcga
3367141 cgccgccacg atagcccttc ctgaattccg ccatgcgtac gaccgcgcgg ccaccatcgg
3367201 gacactcaac gtgtatcgtc gcaactcccc tgacggtgat gaaccgctac ccgcggacgg
3367261 caactaaccc tgcccgcagg cctctagaac gagttcgcgc actcgggccg cgtcggcctg
3367321 tccgcgggtc gccttcatca ccgcaccgac aatcgcgccg gccgcggcca ccttgccgcc
3367381 gcgaatcttg tccgccacat caggatttgc ggccagggcc tcgtcgaccg cggcctgggt
3367441 caacgagtcg tcgcggacca acgccaaccc tctcgcagtc atcacctgtt cgggctcacc
3367501 ttcaccggcc agcacaccct ccacgacttg gcgggccaag ctgttggaca gcttgccctc
3367561 atcgaccaat gccaccacgg ctgcgacctg ggcaggagtg atggccagtt cgtccagccc
3367621 gatgccggcc tcgttggcct tttgcgccag gaagtttccc caccaggcgc gcgccgcctc
3367681 gctggacgcg ccgtgctcga cggtggcagc aaccaattcg acggcgccgg cgttgaccag
3367741 atcgcgcatc acctcgtcgg aaacgcccca ctcctgctga atcctcctgc ggctcaacca
3367801 cggcaattcg gggatcgtct ggcgtagtcg ctcgaccagc tcgcgactgg gcgcgacagg
3367861 ctccaaatcc ggctccggga agtaccgata gtcctcggcg gtctccttgg tgcggcccgc
3367921 gctggtgtaa ccggcctcgt gaaagtgtct ggtttcctgg gtgatccgac caccagacgc
3367981 caaaatagcg ccctggcgct gcatttcgta gcggacggcg acttcgacgc tcttcagcga
3368041 gttgacgttc ttggtctcgg tccgggtgcc gaattcggtc gtcccggccg gcttcagcga
3368101 cacgttggcg tcacagcgca tcgaaccctg gtccatccgg acatcagata catctaatgc
3368161 gcgcagcaga tcccgcaacg ccgtcacata ggaccgggcg atctgcggcg cccgggcacc
3368221 ggcgcccacg atgggtttgg tgacgatctc gatgagcggc acgccggcac ggttgtagtc
3368281 gatcagcgaa ccggtggcac cgtggatccg gcccgtctcg ctgccgatgt gggtgagctt
3368341 gccggtgtct tcttccatgt gagctcgctc aatctccacc cgccaagtgg tgccgtcttc
3368401 caaaggcgcg tccaggtagc cgttgatggc gatcggctcg tcgtactgtg agatctggta
3368461 gttcttgggc atgtcggggt agaagtagtt cttccgggcg aagcgacacc agggtacgat
3368521 ctcgcagttc agcgccagcc cgatgcggat cgccgactcc acggcggccc ggttgagcac
3368581 cggcagcgaa ccgggcaagc ccagacacac cggacacacc tgggtgtttg gctcgccgcc
3368641 gaatgtggtg gtgcagccac agaacatctt ggtcgcagtg gacagctcga cgtgcacctc
3368701 gaggccgagt accggctgga agcgcgcgac gacctcgtcg taatcgagca gttcagcccc
3368761 tgcggccttg gctgccccgg cagcaacagt catagccgcg atcctagttt gagcacccga
3368821 cgtcaaccga agaaggcggc ggcgtcgtcg taacggctct gcggcaccag tttgagtttg
3368881 cgaaccgcat ccgccagcgg aacccgaccg atgtcctggc cgcgcaacgt caccatctgg
3368941 ccgtactcgc ccgcatgcgc ggcgtcggcg gcgttcaccc cgaatcgggt ggccagcact
3369001 cggtcgtagg cggtcggagt accaccccgc tggatgtggc ccaacaccgt cacccggaca
3369061 tccttgttga tgcgcttctc gacctcgacc gccagctgcg ccgctacacc tgtgaaacgc
3369121 tcgtgcccga actcgtcgag accaccctcg cgcagcatga tcgtccccgg agccggtttg
3369181 gcgccttcgg cgaccacgca gatgaaatgc gagtccccgc gctggaaacg gcctttgacc
3369241 agtcggcaca cctcttcgat gtcgaacggc tgctcaggaa tcagggtcat gtgagcaccg
3369301 gaggccagcc cggcgttcag cgcgatccag ccggcatgcc tacccatcac ctccaccagc
3369361 atcacccgct cgtgggattc ggcggtgctg tgcagccggt cgatggcctc ggtggccacg
3369421 gtcaacgcgg tgtcgtggcc gaaggtcaca tcggtgcagt cgatgtcgtt gtcgatcgtc
3369481 tttggcaccc cgaccaccgg cacattctct tcggagagcc aactcgcggc ggtcagcgta
3369541 ccctcaccgc cgatcgggat caggacgtcg atcccgttgt cgtccaaggt ctgcatgatt
3369601 tggggcagcc ccgcccgcag tttgtcgggg tgcacccggg ccgtgcccag catcgtgccg
3369661 cccttggcca gcagccggtc attgcggtcg tcgttgtgca gttgaacacg gcggttctcc
3369721 agcagcccgc gaaagccgtt ctgaaatccg accaccgacg agccgtatcg ggcgtggcag
3369781 gtacgcacca ccgcacggat gacggcgtta aggccgggac agtcgccgcc tccggtaaga
3369841 actccaatcc gcataccctc atcttgccgc gcggccgccg acctggcgcg agcagacaca
3369901 gaatcgcacg ggcgaggggc gccggatgcg agtctgtgtc tgctcgccgc taaatggcgc
3369961 tcagtagcgg gccgcgggcg gcctcataag ccgcccccac ccggtagagc cggtcgtcgg
3370021 ccaatgccgg cgccatgatc tgtaggccaa ccggcaaccc gtcgtccggg gagagccccg
3370081 acggcacaga catgccgcag tggccggcca agttcagcgg cagcgtgcac aggtcgaaca
3370141 agtacatcgc cagcggatcg tccaccttct cacccagccg gaacgcggtg gtcggggtcg
3370201 tgggcgacac cagcacgtcg acggaccgat acgccgcgtc gaggtcgcgg gcgatcagcg
3370261 tgcgcacctt ctgcgcctgg ttgtaatagg cgtcgtagta gccggccgac aacgcgtagg
3370321 tgccgatcat gatgcgccgc ttgacctcgg gcccgaaacc ggcggcccgg gtcatcgcca
3370381 tcacctcctc ggcgctgcgg gtgccgtcgt cgccgacccg cagcccgtag cgcatcgcgt
3370441 cgaagcgcgc cagattgctc gacacctccg agggcagaat caggtaatag gcggccaggg
3370501 catggtcgaa gtgcgggcag tcgacctcgc tgacctcagc gcccagcgcg gttagctgct
3370561 ccacggcagc ctcgaaggag gccagcacgc ccggctggta gccctcgccg ccgtgcagct
3370621 gtcgaaccac gccgacccgc acgccacgca gatccccgac cgcgccggcc ctagcggcgc
3370681 ccaccacgtc gggcacctcg gcgtcgaccg acgtggagtc gcgcgggtcg tggccggcga
3370741 tcacctgatg caacagcgcg gtgtccaaga cggtgcgcgc acacgggccg ccctgatcca
3370801 gcgaggacgc gcaggccacc agcccatagc gcgacaccgt gccgtaggtg ggtttgacgc
3370861 cgacggtcgc ggtcagcgcg gccggctggc ggatcgaccc cccggtgtcg gatccgatgg
3370921 ccagcggcgc ctggaacgcg gccagcgccg ccgcgctgcc gccaccggaa ccgccgggta
3370981 cccggtcgag attccacggg ttgcgggtgg gaccgtaagc ggagttctcc gtcgacgagc
3371041 ccatcgcgaa ctcgtccatg ttggtcttgc ccaggatcgg gatccccgcg gcgcgcaacc
3371101 gcgcggtcag cgtggcgtcg tagggagatc gccatccctc caggattttt gacccgcagg
3371161 tggtgggcat gtcgctggtg gtgaagacgt ccttgagcgc cagcggcacc ccggccagcg
3371221 ccgacggcaa gggttctcca gcggccacct gcttgtcgat ggcggccgcc gccgccagcg
3371281 cctcatcggc cgccacatgc aggaaggcgt ggtacgtctc gtcggtcgcc tcgatctgat
3371341 ccaggcaggc ccgggtgatc tcggccgacg acacctcctt gatggcgatc ttggcggcca
3371401 gcgtcgcggc gtcggatcgg atgatgtccg tcactgttca tcccccagga tctgcgggac
3371461 ggcgaagcgg ccgtcgacgg catcgggcgc ctggtcgagc acctgacgct gggtcaggca
3371521 cggcacggtc tcgtccgggc gggtgacgtt gacgtccttg agcggattgt cggtggcctg
3371581 cacaccggtg acgtcgacgg cctggatctg gctgacgtgg gtcaggatgg cgtcgagttg
3371641 gccggcgaaa ctgtccagct cggtttcggt caatgccagc cgggcaagcc tggcgaggtg
3371701 ggcaacctcg tcgcgggaga tctgggacac gaccgcaaag cctaatgggt ggccggacgg
3371761 ccgacgccgg ctgccgaaac gccgtggata catcgttgtg ccacagtgtt ggccgtgcgt
3371821 tcgtatctat tgcgtatcga gctggccgac cggccgggca gccttgggtc gctggcggtc
3371881 gcgctcggct cggtgggcgc cgacatcctc tcgctcgacg tggtcgagcg cggcaacggc
3371941 tatgcgatcg acgacctggt ggtcgaactg cccccgggag cgatgcccga cacgctgatc
3372001 actgctgccg aggcgctgaa cggcgtccgg gtagacagcg tccgcccgca caccggcctg
3372061 ttggaagccc accgcgagct ggaactgctc gatcatgtgg ccgcggctga gggcgcgacc
3372121 gcacggctcc aggttctggt caacgaggcc ccccgggtgc tccgggtgag ctggtgcacg
3372181 gtgttgcgca gttccggcgg ggagctgcac cgtctggccg gcagcccagg tgcgccggag
3372241 acccgggcca attcggcgcc ctggctgccg atcgagcggg ccgcggcgct ggacggcggc
3372301 gccgactggg tgccgcaagc ctggcgcgac atggatacca ccatggtcgc ggctccattg
3372361 ggtgacacgc acaccgcggt ggtgctgggc aggccaggcc cggaatttcg cccgtcggag
3372421 gtggcgcggt tgggttatct agccggcatc gtggcgacga tgctgcgctg agcggttcgt
3372481 tggcaaccaa ggttcgccga gcgtaacgcc actgcgaaaa accgcgcgga gattcgcagt
3372541 gccgttacgt tcgtgacgcg ggtccgtcgg ccagcagtct ccggaaccca tcctcgtcca
3372601 gaatcggcac ccccaactcc accgccttgt cgtatttgga tcccggcgag tctccggcga
3372661 cgacatagtt ggtcttcttc gacaccgagc cggcggcctt gccgccgcgg gccacgatcg
3372721 cctccttggc gtcgtcgcgg gagaaaccgg tcagcgagcc ggtgaccacg atggtcagcc
3372781 cggccagcgt gcgtggcaca ctctcgtcac gctcgtcgac cattcgcacc ccggcggccc
3372841 gccacttgtc gacgatctcg cggtgccagt cgacggcgaa ccactcggtg accgcggcgg
3372901 caatggtcgg ccccaccccc tcgacggcgg ccagctggtc ggtggacgcc gcggcgatgg
3372961 cgtcaaggct gccgaactcg gtggccaggg cgcgggccgc cgtcggcccg acatggcgga
3373021 tggacagcgc caccagcacc cgccacagcg gtgccgcctt ggccttgtcg aggttgacca
3373081 gcagccgttt gccgttggcc gacagttcgc ctgccttggt tcggaacagg tcggtgcgca
3373141 gcaagtcccg ctcggtcagc gcgaacagct cgccctcgtc ggcgatcacc ttcgcctgca
3373201 agagcgccac acccgcctcg taaccgagca cctcgatgtc taggccgttg cggctggcga
3373261 cgtggaaaac ccgctcccgc agttgccccg ggcagccgcg ggcgttgggg caacggatgt
3373321 cggcgtcgcc ttccttctcc ggcgccaacg gcgaaccgca ctccgggcag gtggtgggca
3373381 tgatgaattc gcgttcggag ccatcgcgca gttcgacgac gggtcccagc acctcgggga
3373441 tcacgtcgcc ggccttgcgg atcaccacgg tgtcgccgat cagcacgccc ttgcgcttga
3373501 tctccgaggc gttgtgcagg gtggcctgtc ccaccgtcga cccggccacc ttcaccggcg
3373561 tcatgaacgc aaacggcgtg atccgcccgg tgcggccgac gttcacccgg atgtcgagca
3373621 gcttggtctg cgcttcctcg ggcgggtact tgtaggcgat ggcccagcgc ggcgcccgcg
3373681 acgtggaacc cagcctgcgc tgcaacgcca cctcgtcgac tttgaccacc acgccgtcga
3373741 tttcgtggtc cacctcgtgg cggtgctcgc cccagtagtc gatgcgctcg cgcacaccgg
3373801 ccaggtcggt tgccagggtg gtgtgttcgg aaaccggcag tccccatgcc cgcaacgcca
3373861 ggtatgcctg atgcagggtg gccgggcgaa agccctccac gtggcccagc ccgtggcaga
3373921 tcatccgcag ccggcggcgc gcggtgaccg ccgggtcttt ctggcgcagc gatcccgccg
3373981 cgctgttgcg ggggttggcg aacggcgcct tgccctcctc gacgaggctg gcgttgagcg
3374041 cctggaagtc gtccagccgg aagaagacct cgccgcggac ctcgaggacc tcgggcaccg
3374101 ggtagtcgtc gccgggggtg agccgttcgg gaacgtcggc gatggtccgg gcgttcaggg
3374161 tgacgtcctc gccggtgcgc ccgtcgccgc gggtggaggc ccgggtcagc cgtccctcgc
3374221 ggtagaccaa agacagcgcg acgccgtcga tcttgagctc acacaggtaa tgtgcggcgt
3374281 ctccgacctc ggcatggatg cggccggccc aggcggcgag ttcgtcggcg gtgaacgcgt
3374341 tgtcgaggct gagcattcgt tcgagatggt cgacgggctc gaaatccgtg gcgaagccgg
3374401 caccgccgac cagctgggtc ggcgaatcgg gcgtgcgcag ctcgggatgc tgctcctcga
3374461 gggcttccag acggcgcagc agctcgtcga attccgcgtc gctgatgatc ggcgcgtccc
3374521 gcacgtaata acggaactgg tgctcacgca cctcctcggc cagtgcctgc cactgccgca
3374581 acacctcggg agcggtctga tcggcgtctg gggagctcac tctggcaggc tagccgaggg
3374641 ggctcttccc tcagatggcc tctgggtccc gcgcgaacgc ctcagcgaca tcacgggcaa
3374701 gcccgaccgc ggtgcgggcc cactgccccg tcgcattggc cagaccacac gccgggctga
3374761 cgccgagtcg atcgcgtagc gccgagcgag gaacgccgag ccgatcggtg accgcgaccg
3374821 ccgcagcagc gacctcttcc atcgaaggtg ctcgctccgg ggcggtcacc gggaccaggc
3374881 ccagcacgac ggttcggccc gactcgacaa atgccgcgac agcatccaaa tccgcagcct
3374941 gcagtgtgct cgcatccacc gataccgcac taattctgct gcgctgcagc agatcccacg
3375001 gcaaatccgg actgcagctg tgtagcgcta cgtccgcgtc gacagccgcg atgcaagtgt
3375061 cgagcagcgc ttcggccacc gtctcgtcga gcggggcaac cgggctcaac gcggtcaccc
3375121 cggtcagccg gccgcccaac gccgccggca acgacggctc gtcgaactgc accaccaccg
3375181 gtgtgtcaag tcgacgcgcc agcgccgcgc gatgcgcggc aacgccttcg gccagcgagg
3375241 cggccaggtc acgcacggct ccggggtcgg tgatcgcccg gtgaccgttg gccagctcca
3375301 accccgcgac caatgtgact ggcccgggcg cctgcacctt caccgcccgc ccacagccac
3375361 gcaggcccgc ggtctcccag gcctcttcta aggcatccat atcctcgtcg aggaggctcg
3375421 cggcccgccg tgtcaccgcg ccgggtcgag cagcgatgcg gtagccacga ggcacggtgt
3375481 caatcgccac gtcgaccagc agtccgccgg ctcgccccag catgtcggcg ccgacgcccc
3375541 tggcgggcag ctcggtgaga taggccaatg cacccgccaa ctccccgacc acgacctgcg
3375601 cggcctctcg cgcggcggtg cccggccacg atccgatccc ggtggccgtt gcgaaaacac
3375661 tcacccggca accgtattcg acctcacatc gtcggctggc cgccaggggt gtctgctgca
3375721 ggttcgcccg ggtaccttcg aagcagaagg gtggcagatg gtgggattga cgcggccgct
3375781 gctgttatgt ggcgcgacac tactgattgc ggcgtgcacc cgggtggtgg gcggcacggc
3375841 ttcggcgact tttggcggtg accgacaggg catgcttgac gtcgctacga tcctgttgga
3375901 tcagtcacgg atgcaagcaa tcaccggctc cggcgatgac ctgacgatca tccccacgat
3375961 ggacacgacg tatcccgtcg acgtcgacga tttcgcccaa cccataccac gagaatgccg
3376021 gttcatctat gccgagacgg cagtctttgg ctctgagatc gaagcgtttc acaagaccac
3376081 cttccaggac cggccagatg gcagtctgat ctccgaggcg gccgccgcct atcgggatgc
3376141 cggcaccgcc cggcgtgcct tcgacaccct ggcggtcacc gtccacgact gcgcggcaag
3376201 tccggcaggc tggctgttcg tcagtaggtg gaccgccggc ggcaattccc tacacatccg
3376261 ggccggcgat tgcggtcgcg actaccgggt cctatcggcg gccctgttgg aagtgacctt
3376321 ctgcggcttc ccggaatcgg tctccgacat cgtgatgacg aacatcgccg ccaacgtgcc
3376381 gggttagcac ctcgagcccg cgttcaggat gccaggacgg atgtcaacgt ggtcagttgt
3376441 gcgttgcgct gcgcgacgac attggtgctg acatttccac cacgcgcgtt tagtctccgg
3376501 cgtcggcggc cgtggctgga cccgcatggc gcgggtccag ccaccgaccc cggaacgacc
3376561 ccaccctaat cgttccgcag tctgacgaat cgcctaccgg cctttccagc accccgatct
3376621 ggcgtagtgc tcgccggcac cgacggtagg cccgcgcgag agcctccatg gcctgattcc
3376681 actgggcctg ccagtcctga tgactcatcc cgagatcacc ttggcaagca cgcgacggcg
3376741 cggtgcgctc actggcgata tcggccccca agctctgcgt cgtgcccgta taaccggcca
3376801 tgtctccgac attggccgtc atcgccgggt agctgtacat actctgcgac accacgaatc
3376861 cctttcaaat attccgggca atgattttta gacactcttt cgatcgaaaa tttggtcgag
3376921 ttcacggccg tcagatcgtc aaactgacac caacccccca tcaccggcca caccgaccaa
3376981 atccggcccc cagctgcccg gcagcatcgg caccggcgca ccatcaccaa actcatcggc
3377041 caacaccgtc aaccccgccg gctgcccaac cgactccttg ccagccgtcc caacaaaccc
3377101 caacgcccca gcaccccgat cagaagccag caccgacacc gacgtgctcg cgggagccgg
3377161 ctccaccgcc gacaccaacc gcgcctgcgg cgacaccaca ccacccgaca ccggcgccac
3377221 actgcccacc aacgccgccg gcgcgccagc agccgcaccc accgccggca gagcggccaa
3377281 tcccgccacc ccggccaacc cagctacacc cggaaccaca gcagcggcca acgcccccaa
3377341 caacggcccc cccaaaaggg gaacaacacc aaacagattc ccaataaccc actcgacaac
3377401 tatgtctata acgcccgcaa tggcatacaa taatccgacc gcaacataag aagcattgat
3377461 agcgaactct gtcaatagtt gagcattgga tgccaacgta ataatgaacc caataatgtt
3377521 gaaacccagg atatccacaa agagctggaa ccaaacccaa gccaccgcag ggagttcgga
3377581 aagcaaagcg gacagatact ggtcatatgc tgcgaacgtt tcttctaaaa actgtacaat
3377641 ttcgtgccat gggaatgggg ttatggttgc ggcggccacg gcgttgctgg cttcattggc
3377701 gccgggtttg acgatgaccg gtgccgggcc ggtgtgtggt gtggccacca gcgcggcacc
3377761 caccaccgcc tcataggcgc tcatcacggt ggccgcctgg acccacatcc gcacatagtc
3377821 ggcctcgttg agcgcgatcg ggatcgtgtt gatcccaaag aaattcgtcg ccaccaacac
3377881 cgcatgcgtg aggtggttgg ccgccaactc cggcaacgtc ggcatctccg ccaacgcaca
3377941 aacatagcca gccgccgcgg cctcatgctc accggccgcc gccgcgctat ccgcactggc
3378001 ctgcaccaac cacgccacat acggcacata ggcggccaca aacaactcag cactgggacc
3378061 ctgccacacc ccggccccca ccgcggccac caccacgctc aactcttgcg ccacagcggc
3378121 gtactcggcg cttaacgcgc tccaccccgc cgcggccgcc tgcaacgaac ccggccccgg
3378181 accagcactt agcagcgccg aatgcacctc cggcggcgac gccaaccaca ccggcgccgt
3378241 cacaacgacc cacccgaaac cagatacgtg cccaggacac cgaactcgac cgtgcggtgc
3378301 gaggacaccg gatcacccgc tagcggaatc aatgtgcggc ggccagccgt gcggtcaacg
3378361 cctccaccgc cgcactggcg gccgccaaac cctcaggaac cacgctcagc gtcaccacgc
3378421 acactccttc cttaggcgcc tcccacaccc atctcccgga tttttgctct atcaactgtt
3378481 gtaaatagct acgattaccc aggcgtagac gacgacgccg cagattcctc acacccgcgc
3378541 ctgcgcaatt ggccacgcac caccgccggc agcgaggccg ccagccacac accaagctcc
3378601 tcgccgacca catcggctac cggatccacc aacagcgcaa cggcattcgg atgggggccc
3378661 atcaaaccca ccgatcatcc cggcgtcgcc gaccacgccc gcgccgtgtg ctagccgccc
3378721 cacttggcgg cttcggcccc atctcgagcc aacatcgcca tggtgttgga ctcatgggtg
3378781 ccagacatcg actgataggc ccgcaccaga tcctctaggg cctggttcca ctgggtctgc
3378841 cagccctgat acgtgatccc ggtatcaccc tgccaagcac tggacagcac ggcctgctca
3378901 ctggcgatat cggcccccaa gctctgcagc gtgcccgcat aaccggccat gtccccggca
3378961 tgagccatca tcgccggata gttgtacata atctgcgaca tcacaaaccc cttttcattc
3379021 cgagcagcga cttttttaaa acccggtgta gctggacgcg gcggcggcat cggcggccac
3379081 atacgtgccc gcggcctcac ccaaattggc ttgcgcgata tccagcaagg tattgacctt
3379141 ggcggccgcg gccacaaacc gggcatgcgc accctgaaac gccgccgcgg actctccctg
3379201 atgaaacgcc tgcgccgaca tcgcctgctg ctcggcctga ccgatcgtat gccgcatcaa
3379261 ccccgcctta gcggcaaacg ccgtatgcga agcgatcaac tgcggaatat gggcatccaa
3379321 caaactcatc acaattcctt ccaattcgaa tcaccaatta ctcgccgtca gatcgtcaaa
3379381 ctgacaccaa ccccccatca ccggccacac cgaccaaatc cggcccccag ctgcccggca
3379441 gcatcggcac cggcgcacca tcaccaaact catcggccaa caccgtcaac cccgccggct
3379501 gcccaaccga ctccttgcca gccgtcccaa caaaccccaa cgccccagca ccccgatcag
3379561 aagccagcac cgacaccgac gtgctcgcgg gagccggctc caccgccgac accaaccgcg
3379621 cctgcggcga caccacacca cccgacaccg gcgccacact gcccaccaac gccgccggcg
3379681 cgccagcagc cgcacccacc gccggcagag cggccaatcc cgccaccccg gccaacccag
3379741 ctacacccgg aaccacagca gcggccaacg cccccaacaa cggccccccc aaaaccggaa
3379801 tagcgccaaa aatattcgaa ataatccaac caatactgag tatcgccagt tccaagacaa
3379861 ccgcgaattc taatagcgga accagaacaa atacgcctaa cgcaaaacct accgtggcga
3379921 aaaacatatc gatcatcccg gtaaggacga gccaaggctc gaaatttacc agacccgtga
3379981 tcagctcgac gaatcccaca gcccaggctt cggcgctctt cattatcaat tcgccgacct
3380041 ctgtaaatgc ttgggcagcc atttccaaaa acttcgctaa ttctccgaat gggaatgggg
3380101 ttatggttgc ggcggccacg gcgttgctgg cttcattggc gccgggtttg acgatgaccg
3380161 gtgccgggcc ggtgtgtggt gtggccacca gcgcggcacc caccaccgcc tcataggcgc
3380221 tcatcacggt ggccgcctgg acccacatcc gcacatagtc ggcctcgttg agcgcgatcg
3380281 ggatcgtgtt gatcccaaag aaattcgtcg ccaccaacac cgcatgcgtg aggtggttgg
3380341 ccgccaactc cggcaacgtc ggcatctccg ccaacgcaca aacatagcca gccgccgcgg
3380401 cctcatgctc accggccgcc gccgcgctat ccgcactggc tgcaccaacc acgccacata
3380461 cggcacatag gcggccacaa acaactcagc actgggaccc tgccacaccc cggcccccac
3380521 cgcggccacc accacgctca actcttgcgc cacagcggcg tactcggcgc ttaacgcgct
3380581 ccaccccgcc gcggccgcct gcaacgaacc cggccccgga ccagcactta gcagcgccga
3380641 atgcacctcc ggcggcgacg ccaaccacac cggcgccgtc acaacgaccc acccgaaacc
3380701 agatacgtcg ccgccgccac cgcatcaccg gcggcataac cgatcccaga ctcacccaca
3380761 gcgaccccgg aacgacccag ctcctcgacc ccttcgcccg cgatcgccgc atgctcgcta
3380821 cctaaggcgc taaaccccac cgcactctgc aacgacaccg gatccgccgc cggcgccacc
3380881 accgccgtaa tcgccggcgc cgcgccagcg tgtgcggcgg ccagccgtgc ggtcaacgcc
3380941 tccaccgccg cactggcggc cgccaaaccc tcaggaacca ctctcagcgt caccacccac
3381001 actccttcct taggcgtcac acacccgcac gaccggttac cgtcaccagc ggagcgaatt
3381061 attgacacct gtcttgacgc ctgtcttgac atgcgtcagg caatattgat ctcacagatc
3381121 gttgcgtatg tcaactgtta ttgatagcta ctattacgta ggcgtaggtg acggctccgt
3381181 aggattcggg gactagcccg ttgcttgggc tgcccgaccc ccgccccgtc ccacgcaacc
3381241 cggctgcccg tcgtcgggcg acatcccggt ctctatcggc ggacccgagc agccgcccgg
3381301 ctagccagtc gcggccaagg ccagggacgt ggtgtacgag tgaaggttcc tcgcgtgatc
3381361 cttcgggtgg cagtctaggt ggtcagtgct ggggtgttgg tggtttgctg cttggcgggt
3381421 tcttcggtgc tggtcagtgc tgctcgggct cgggtgagga cctcgaggcc caggtagcgc
3381481 cgtccttcga tccattcgtc gtgttgttcg gcgaggacgg ctccgacgag gcggatgatc
3381541 gaggcgcggt cggggaagat gcccacgacg tcggttcggc gtcgtacctc tcggttgagg
3381601 cgttcctggg ggttgttgga ccagatttgg cgccagatct gcttggggaa ggcggtgaac
3381661 gccagcaggt cggtgcgggc ggtgtcgagg tgctcggcca ccgcggggag tttgtcggtc
3381721 agagcgtcga gtacccgatc atattgggca acaactgatt cggcgtcggg ctggtcgtag
3381781 atggagtgca gcagggtgcg cacccacggc caggagggct tcggggtggc tgccatcaga
3381841 ttggctgcgt agtgggttct gcagcgctgc caggccgctg cgggcagggt ggcgccgatc
3381901 gcggccacca ggccggcgtg ggcgtcgctg gtgaccagcg cgaccccgga caggccgcgg
3381961 gcgaccaggt cgcggaagaa cgccagccag ccggccccgt cctcggcgga ggtgacctgg
3382021 atgcccagga tctctcggta gccctcggcg ttgacgccgg tggcgatcaa ggtgtgcacc
3382081 ccgacgacgc ggcctgcctc gcgcaccttg agcaccaggg cgtcggcggc gaggaaggta
3382141 tacgggccgg catcgagcgg gcgggtccga aacgcctcta cggcttcgtc gagctctttg
3382201 gccatgatcg acacttgcga cttggaaagc tttgtcacac caagtgtttc gaccaggcgc
3382261 tccatccggc gagtggatac tcccagcagg tagcaggtcg ccaccacgct ggtcagtgcg
3382321 cgttcagctc gcttgcggcg ctgcagcagc cagtccggga aatagctgcc ctggcgcagc
3382381 ttggggatcg cgacgtcgat ggttgcggca cgggtgtcga aatcacggtg gcggtagccg
3382441 ttgcgctgat tggaccgctc atcgctgcgt tcgcggtagc ccgccccgca cagggcgtcg
3382501 gcttcagccc ccatcaaggc ggcgatgaac gtcgagagca gcccgcgcag cagatccggg
3382561 ctcgcctgtg cgagttggtc agccagaagc tgctcggcgt cgataagatg agaagaggtc
3382621 attgcgtcat ttccttcgat tgacttttgc tggtcgtttc gaaggatcac gcgatgaccg
3382681 cccactactg ggctacgaca cgcccaccgg ccttacctgc ccgtacacca cacccctgga
3382741 cgtaactcca gtcgccgggt ttctacgagt gatttggcgc cgagtcaagc cccggggttg
3382801 ccgccagtcg acaaccctga agcgccggcg atggtcgcgc tgccgagcac ctcgtcaccg
3382861 gctgggtcag gtcggtagag caccagcgtc tggccgcgcg ccacgccgcg cagcggggca
3382921 tgcaactgca cgaaaagcgc atcgccgatc aattccgcta ccgcactgac ggtttcaccg
3382981 tgcgcacgca cttggaccac gcagtcaacg ggtcctgacg gcgcggctcc ggcggtgaag
3383041 acgggagcgc gcccagtcag cgtttgcaca tcaaggtcgg tcacgtcacc tacgtgaacg
3383101 gtggcggtgt cggcgtcgat cgccgtgaca tagcgcggac gaccattcgg gcccggcccg
3383161 gcgatgccca ggcctctacg ctgcccgatg gtgaacccgt gcaccccatc atgggaagcc
3383221 agcaccacac catccgcgtc aaccaccaca ccacggcgaa ccccgatgcg ctcacccaaa
3383281 aaagccttgg tgttcccgga cggtatgaag cagatgtcgt ggctatccgg cttgttggcg
3383341 accgccaggc cgcggcgggc cgcctcggca cggatctgcc gcttcggcgt gtcgccgatc
3383401 gggaacgcgg cgtggcgcag ctgctgcgca gtgagcacgg caagcacata agactgatcc
3383461 ttgtcccggt cgacggcgcg gcgcagccgc ccacccgaca gccgggcgta gtggccggtg
3383521 gccaccgtat cgaaacccaa cgccacagcc ctggcggaca gagcagcgaa cttgatctgc
3383581 tgattgcacc gcacgcaagg gttcggagtt tccccgcggg catacgacga cacgaagtcg
3383641 ttgatcacgt cctctttgaa cttctctgcg aaatcccaaa cataaaacgg gattccgagc
3383701 acatcggcga cgcggcgcgc gtctgcagcg tcctctttgg aacaacagcc ccgcgagccg
3383761 gtgcgcagcg tgccgggcgc ggtcgatagc gccatgtgca ctccgaccac ctcgtgtccg
3383821 gcatcgacca tgcgggcggc agcaacagac gagtcgacgc caccgctcat cgcggcgaga
3383881 actttcatcg ggatgctccc gcggcggcta gggcggcccg ccgtgcacgt gccaccgccc
3383941 cgggaagcac ctccaacgcg gcatcgacat cagcctcaac actggtgtgc cccagcgaga
3384001 gacgcaatga tccgcgggcg ctggccgcgt cgacgcccat tgcaatcaac acatgcgagg
3384061 gctgcgctac acctgccgtg caggccgatc cggttgagca ctcgattccg ttagcgtcca
3384121 acaacatcaa cagcgcatcg ccttcgcagc cacggaaagt gaagtgcgcg ttacccgcta
3384181 gccgcatcgg gtcatcggcg ccgttaaggc aaacatcgtc aatctcagcc agcacaccct
3384241 cgaccagacg atcccgcagc agccgtaacc gcgcgctgtt ttcctcgagt ccgtccaccg
3384301 cgatctgcgc ggccgtcgcc attccaactg cactggcgac atcgggtgtg ccggaacgaa
3384361 tatcgcgctc ctgcccaccg ccgtgcataa ggggcacgca ggtgacgtcg cggcgcagca
3384421 gcaacgcacc cactcctggc gggccaccga atttgtgccc ggccacgctc atcgccgaca
3384481 gcccgctggc cccgaagtca agcgggagct gtcccaccgc ctgaatggca tcactgtgca
3384541 tcggcacgcc gaattccatg gcgacaactg acatttcggc gatcggtaga atagttccga
3384601 cctcgttgtt ggcccacatc accgatacca gcgcgacgtc gtcgtggctc tgcagtgcct
3384661 cgcgcagcgc agttgccgac accgagccgt cggcggcggt cggcagccag gtcacatggg
3384721 cgccttcgtg ttccacgagc cagttcaccg agtccagtac ggcgtggtgt tccacctcgg
3384781 tggtgacgat gcgacggcgg tgcggctccg catcgcggcg tgcccaatag atacctttga
3384841 cagccaggtt gtcgctttcg gtgccgcccg cggtgaagat cacctcggac ggacgagcgc
3384901 ctagcttgtc cgcgatcagc tcacgggcct cctcgatccg ccggcgcgcc gagcgcccgc
3384961 tggtgtgcag cgacgacgca ttgccgatgg tgcgctgcac ggccgccatc gcctcgatgg
3385021 cggcggggtg catcggggtg gtggcagcgt gatccaggta ggccatgacg cacctagaat
3385081 actggcccgg gcggcgacgc agaacgtgcg cgcaggccac ggccgcagca gcggctgggc
3385141 aatctggctg gggccagacc acttaggtcg ccggcacgtg ccggcggcct gggcgttgcc
3385201 ccgactgccc caaggctccc gcaagcaccg ctgactggca acggcgcgcg agattccgac
3385261 gatcggtacc tggcagctgc aaagactcga cgcgcaccca ggccagcgtg cggcgcacgg
3385321 tcagcagccg gcaaaccgac cgcaccaagg tgtcgtcgcc gacaaaggcc ggagcggtcg
3385381 agacggtgcc gtcgacgtgg tgatatgtca accggagtgg ctgcaccggg cggccggcat
3385441 cgattgcggc ctggaacatc gccggataga aagccccaca accgcgatgc gagcacccgg
3385501 ctcctgctcg ggccgctgga cggccggcat cgtcgcccgg ccgaccgcac caggtggtgc
3385561 cctcggggaa ggccaccacc gtctgaccgg cgcgcagccg acgcgcgatg gtatcgacaa
3385621 ccccgggaag ccgccgcagg ctggctcgct cgatcggaat gatcttcaga atgcgcgcca
3385681 cgatccctat agtccgtccg gtgaacatgt cggcgcgcgc gacgaacgac ccgggcaaca
3385741 ccgaaccgat gcagaagacg tccaaccagg acacgtgccc gctgaccacc aggactccgc
3385801 gcaggttccg aactggacta cccgacaccg tgatccggac accgaaaagg cgcagcacca
3385861 accggcagta gatgcgttgc acccgcgttc ggcccggcag tggcatcacc accagcggca
3385921 ctcccggtac caggagcaga gccaacatga cgcgaagcgc tacccgcagc accaccagcg
3385981 gccgccgcac ctgcgcagcg tcgccgacac tcacgcagct gacgccgcac gttgcgcggg
3386041 gcaaccagga gtgttcggtg actgcgggag cgctcatcgc gcgtcgttca ccatttccga
3386101 ggccgccgca accgaccgca gtcgtcgcag atatcgcgta tcggcgtggt ccttatccag
3386161 tagcaggcag aagtcgccca cgccaaagtc cgggtcgtgc gccggctccc cgcaggcccg
3386221 cgcgcccagt ctcaggtaac cgcgcatcag cgggggaact gctggccgtg gcggagggag
3386281 aatgtcgtcg agggacctcc cgtccacgcg caccggccgg taggggtaca cctggcactg
3386341 cggcggcgcg gcatgccggt tgaggatgaa gtcgcgcacc ccacgcagcc ggctgcccgg
3386401 cgtttcaccg tctcccccga ttggtactga cacacatccg gtcacatagt catagccgta
3386461 tcggtccagg taggccagga tgcccgccca catcaacaac accaccccac cgttgcggtg
3386521 accctcgcgc accacggcgc ggcccatctc caccaacgac ggccgcagcg gatcgaacgc
3386581 gcaaacgtcg aattccgttg cggtgtagag tcctccggcg gcgatggcac ccgccggtgc
3386641 cagcatccgg tagcaaccca ccagctcacc ggtgtcgtcg tcgcggacca gcaggtgatc
3386701 gcagtactcg tcgaaccggt cgccatcccg gcgcgtatcc gcggccgccg gcagtgcgaa
3386761 gcctggcgta gtgctgaaca cgtcatagcg gagccgctgc gccgcctcga ccatgctggg
3386821 atcggtggat agcaacaggg aatagcgcgg tccggttgac gatcctgtcg cgacgccatg
3386881 cggtttgtca ctgggtatca gcacagaagc gatgctcata gcaccaacgt ggcgcagccg
3386941 atcagctaat cggcatcaac gttgtgacgt gtcggtgcac gtcagatgac gaactgttgg
3387001 gctaggtgag caggcgccaa ggccccccac gcctcggcgt gtcggggtct tttgcgactg
3387061 ctcgcgcagg gaacctagcc cttgcgggcc ttgatggcct cggtcagctg cggagcgacc
3387121 ttgaacaggt ctcccaccac cccgtagtcg gcgatctcaa agatcggcgc ctcttcgtcc
3387181 ttgttgaccg cgacgatggt cttggacgtc tgcatgccag cgcggtgctg gatcgccccg
3387241 gagatgccca gggcaatgta gagctggggc gacaccgtct tgccggtctg gccgacctgg
3387301 aactggcccg ggtagtagcc ggagtcgact gcggcacgcg aggccccgac cgcggcgccc
3387361 agcgagtcgg ccagcgcctc gaccacgctg aagttctccg cgctgccgac accacggcca
3387421 ccggccacca caatggtcgc ctcggtcagc tccggccggt cgccggcgac cgccggttcg
3387481 cgcgcggtga tcctggcggc gttctccgcc gcagccggca cttccacgct gacctgctca
3387541 ccggcgccgg cggccggctc cgcctccacg gctcctgcgc gcacggtgat caccggggtg
3387601 tcgccgttgg cctgcgcttc gacggtgaac gccccaccga agatgctgtg gacacccact
3387661 ccaccttctc tcacgtcgac cacgtcgacc agcagacccg agccgatccg agccgcaagt
3387721 cggccggcga tctccttgcc gtccgcggtg gcggcgatta gtacgccggc aggggccgag
3387781 gactcggcca gcccggccag cacgtcgacc gccggggtga tcaggtattt gtcgacaagg
3387841 tcggactcgg cgacgtagat cttggcggca ccagccgcct taagcccgtc caccagcggc
3387901 gcggccgtcc ccggcacacc gacgacgacg gcggctggtt cgcccaaggc gcgggcggcg
3387961 gtgatcaatt cggcgctgac cttctttaac gcgccttcag cgtgctcaac gagcaccagt
3388021 acttcagcca tgggttatat cgctctcgtc tttgggaggt gcgtatgtct tagatgattt
3388081 tctgggcaac caggtactgc acgatctggt tgccgccttc accctcgtcg gtgaccttct
3388141 ccccggcagt cttggccggt ttgggcgtcg acgccagcac ggtggatccg gcgttggcca
3388201 gccccacctc gtcgctctcg acaccgatct cggccagggt cagcacggta acttccttct
3388261 tcttggcggc catgatgcct ttgaaggacg ggaagcgcgg ctcgttgatc ttctcgttca
3388321 cgctgatcac cgcgggcagc gtggcctcga gggtgaatac gccctcatcg gtctcacgct
3388381 cgccggtgat cttgccgccc tcgatcgaca ctttgcgcag gtgggtgagc tgcggcaggc
3388441 ccaggtactc ggcgatgatg gccggcaccg caccgcccac cccgtcggtc gattcgttgc
3388501 ctgcgatcac cagctcggtg ccctcgatgg tgcccaacgc gcgcgccaaa gcccacccgg
3388561 tttggatgac gtccgagccg tgcatgccgt cgtcctttag gtggacggcc ttgtcggcac
3388621 ccatcgacag cgccttgcgg atcgcctcgg tggcgcgctc ggggcccgcc gtcagcacgg
3388681 ttaccgaccc ttcgatgccg tcggcggcct ctttctcccg aatctgtagc gcttcctcca
3388741 cggcgcgctc gttgatctcg tccagcaccg cgtcggcggc ctcgcggtcc agcgtgaaat
3388801 cgccgtcggt cagcttgcgc tccgaccagg tatctgggac ctgcttgatc aggaccacga
3388861 tgttcgtcat gactgtggtt cgtcctcctc gaaggcggcc cgcagcgctc gactgcggaa
3388921 cctcggtcac acgttttgca accgcacagc gatattacta ttcggtaagt tcgcgtggtg
3388981 cgccctcaca ccatagcggg tggtagagca ggttcccacg cctgtgcctc gcccacgacc
3389041 ggcggatact cccggtgccc ggttcgcgaa tccgatgcca cgggttagcc tgccttaaca
3389101 atgtgcgcat tcgttcccca cgttccccgc catagccgag gcgacaaccc gccgtcggcc
3389161 tccacggcta gccctgcggt gttgacgctg accggcgagc gcaccatccc cgatctggac
3389221 atcgagaact actggtttcg ccgccaccag gtcgtctacc agcggctggc accccgctgc
3389281 acggcccgcg acgtgctgga agccggctgc ggcgagggat atggcgccga cctgatcgcc
3389341 tgcgtcgctc gccaggtcat cgcggtggac tacgacgaga ctgcggtggc ccatgtccgg
3389401 agccgctatc cccgagtgga ggtgatgcaa gcaaacctgg ccgagctgcc attgcccgac
3389461 gcgtcggtag acgtcgtggt caacttccag gtcatcgagc atctgtggga tcaagcccga
3389521 ttcgttcgcg agtgcgcccg ggtactgcgg ggctcgggac tgttgatggt gtccaccccc
3389581 aaccggatca ccttttcccc cggccgcgat accccgatca acccattcca cacccgcgag
3389641 ctcaatgccg acgagctcac ttcgctgttg atcgacgcgg gattcgtcga tgtggccatg
3389701 tgcgggttgt ttcatggccc acgcctgcgc gacatggacg cccgccacgg cggctccatc
3389761 atcgacgcac agatcatgcg ggcggtggcc ggcgcaccgt ggccacccga gctagccgca
3389821 gacgtcgcgg cggtcaccac cgccgacttc gagatggtgg cagcgggtca cgaccgtgac
3389881 atcgatgaca gcctggatct gatcgcgatc gcggtgcggc cttgaacacg tccgcaagcc
3389941 cggtgcccgg cctgttcacg cttgttctgc acactcacct gccctggctg gcccaccacg
3390001 ggcgctggcc ggtcggcgag gaatggctct atcagtcgtg ggcggcggcc tacctgccgc
3390061 tgctgcaggt gctggccgcg ctggccgacg agaaccggca ccggttgatc accctcggga
3390121 tgacgccggt ggtcaacgcc cagctcgacg acccatactg cctcaacggt gtgcatcact
3390181 ggctagccaa ctggcagctg cgcgccgaag aggccgccag cgtgcggtat gcccgtcagt
3390241 cgaagtcggc tgactatccg tcatgcacac cggaggcgtt gcgggccttt gggattcgcg
3390301 aatgtgccga tgcagctcgc gcgctcgaca acttcgccac gcggtggcgg cacggcggca
3390361 gcccactgct gcgcggcctg atcgacgccg gcacggtgga gctgctcggt ggcccacttg
3390421 cccacccgtt ccagccgctg ctggcaccgc ggctgcgcga gttcgcgctg cgcgaaggcc
3390481 tcgccgatgc tcagctgcgg ctggcgcacc gcccgaaagg gatctgggca cccgaatgcg
3390541 catacgcccc ggggatggag gtcgactacg ccaccgcggg ggtcagtcac ttcatggtcg
3390601 acggcccgtc gctgcacggc gacaccgcgc tgggccggcc ggtggggaaa accgatgtgg
3390661 tcgccttcgg tcgcgacttg caggtcagct accgggtgtg gtcaccgaaa tccggctacc
3390721 ccgggcacgc cgcctaccgc gacttccaca cctacgacca cctgaccgga ctcaaaccgg
3390781 ccagggtcac cgggcgtaac gtgccgtcgg agcaaaaggc accctacgat cccgagcgcg
3390841 ctgaccgcgc cgtcgacgtc catgttgccg atttcgtcga cgtggtgcgc aatcggctgc
3390901 tctccgagtc cgagcgcatc ggccggcccg cccacgtgat cgccgccttc gacaccgagt
3390961 tgttcggcca ctggtggtac gagggcccaa cctggctgca acgggtattg cgggctttac
3391021 ccgccgccgg tgtccgggtg ggcaccctga gcgatgcgat cgccgacgga ttcgtcggcg
3391081 acccggtcga attgccaccc agctcttggg gttccggcaa ggactggcag gtgtggagcg
3391141 gtgccaaggt ggccgatctg gtccagctca acagcgaagt ggtcgatacc gcgttgacca
3391201 ccatcgacaa ggcgctggcc cagacagcgt ccctggacgg accgctgcct cgcgatcacg
3391261 ttgctgatca gatcctgcgc gagaccctgc tcaccgtgtc cagcgactgg ccgttcatgg
3391321 tgagcaagga ctccgccgcc gactacgccc gctatcgtgc tcacctgcac gcacacgcca
3391381 cccgggagat cgccggcgcg ctggccgcgg gccgacgcga caccgcacgg cggctcgccg
3391441 aagggtggaa ccgcgccgac ggtctgttcg gcgccctgga cgctcggagg ctgcccaagt
3391501 gaacgcctcg cacaggcgga accggccgcg cgcatgagga tcctcatggt gtcgtgggag
3391561 tacccgccgg tggtgatcgg cggactcggc cgccacgtgc atcatctgtc gaccgcgcta
3391621 gccgcagccg gtcacgatgt cgtcgtgttg tcccggtgtc cgtcgggcac cgatcccagc
3391681 acacacccat cctccgatga ggtgaccgaa ggggtccggg tgattgcggc cgcgcaggac
3391741 ccgcacgagt tcacgtttgg caacgacatg atggcctgga ccctggcgat gggccacgcc
3391801 atgatccgcg ccgggctgcg cttgaagaaa cttggcaccg accgctcgtg gcgtcctgac
3391861 gtcgtgcacg cacacgactg gctggtggcc catccggcca tcgcccttgc ccagttctat
3391921 gacgtgccaa tggtttccac gattcatgca acggaggccg gtcgacattc cggctgggtc
3391981 tccggagctc tcagccgtca ggtgcacgcg gtcgagtcgt ggctggtgcg tgaatccgat
3392041 tcgctgatca catgctcggc gtcgatgaac gacgagatca ccgagctgtt cgggcccggg
3392101 ctggccgaga tcaccgtgat ccgtaacggc attgacgcgg cgcgctggcc gttcgcggcc
3392161 cgccgcccgc gcaccgggcc agccgaattg ctctatgtgg ggcggctgga gtacgagaag
3392221 ggcgtgcacg acgccatcgc cgcgctgccg cggctcaggc gcactcaccc aggcaccaca
3392281 ctgaccatcg ccggcgaagg cacccagcag gattggttga tcgatcaggc ccgcaaacac
3392341 cgggtgctca gagcaaccag gttcgtcgga cacctcgacc acaccgagct gctggcgttg
3392401 ctgcaccgag ccgacgccgc ggtgctgccc agccactacg aaccgtttgg gctggtggca
3392461 ctggaggccg ccgcggccgg caccccgctg gtgacgtcca acatcggcgg tctgggtgaa
3392521 gcggtcatca atggacagac cggggtgtcg tgtgcacccc gcgacgtagc ggggctggcc
3392581 gccgcggtgc gtagcgtgct cgacgatccg gccgccgcgc agcggcgcgc acgagccgcc
3392641 cggcaacggc tcacctccga cttcgactgg cagacggtgg ccaccgcgac cgcgcaggtg
3392701 tacctggcgg cgaagcgcgg tgaacggcag ccgcagcccc ggttgcccat cgtcgagcac
3392761 gctcttcccg atcggtagcc gtggcaggga cgtgatgatc ggagcaccgc agtgaaaccg
3392821 caggaccagg ggctccactt cccctatcgc tacgaccttc gactggcgcc tatgtggcta
3392881 ccgtttcgat ggccgggcag ccaaggcgtg accgtgaccg aggatggccg cttcgtcgca
3392941 cgctacgggc cgtttcgcgt cgaggcgcca ctgtctagcg tccgcgatgc gcacatcacc
3393001 ggcccatacc gatggtggac agcggtgggc ccccgactgt cgatggtcga cgacggactc
3393061 acgttcggaa ccaacgcagc tgccggtgtc tgcatccact tcgagccgcg gatccaccgc
3393121 gtgattggac tgcgggacca ttcggcgctg acagtgaccg ttgcggaccc cgaagggctg
3393181 gtcgccgcgc tcagcagcta gttcgccgag cgccccgtgc tgggcacaac ccgactcggc
3393241 ctggaggcgc ctgcatccaa gccgcaccgg cgcacaatta tctgccggag gtcaaccccc
3393301 tttatcgatt cggtatcgaa gacgccgttt gacatgccat gatcggcgaa ttcgcagttt
3393361 cagatgccag ggaggcgaca tggctcactc gatcgttcgc acgctgctgg cctcaggtgc
3393421 cgccacggcc ctgatcgcca ttcccacagc ctgctcgttt tcgatcggaa cgtcgcactc
3393481 gcactcggtg agcaaggccg aggtcgcccg gcagatcacc gccaagatga cagacgccgc
3393541 cggcaacaag cccgaatcgg tgacgtgccc aagcgatctc ccggcagagg tcggggccga
3393601 gctgaattgc gaaatgaaga tcaaggaccg cacgttcaac gtcaacgtca ccgtgaccag
3393661 tgtcgacggt agcgacgtca agttcgacat ggtggagacc gtcgacaaga accaggttgc
3393721 caacatcatc agcgacaaac tgttccagcg ggtgggcgcc aggcccgatt cggtgacctg
3393781 ccccgacaat ctaaagggcg tcgagggagc caaactgcgg tgtcgactga ccgacggcag
3393841 caaaacgtat ggcatctcgg tgattgtcac cagcgttgac gccggcgatg tcaacttcga
3393901 tttcaaggtc gatgaccacc ccgagtaggc tcaccgtgga atcggctgcc cggcagccaa
3393961 tttcgcgtac ccgatgtgga tggtcgccgg agcaccatcg gctttagggt gctcggggct
3394021 agcgggccgc cttcttgcgt tcgatgtcgg ccaaggcagc ggctagctca gcgcgctgcg
3394081 cggccgatgc ctcccaggac agctggcggt tcttgaccac cttggccggc gccccgaccg
3394141 cgatcgaata gtcgggaatt gcgccgcgga ccaccgcgtg cgagccgagc acgcagcccc
3394201 gtccgatggt ggtgccgcgc agcacgctca ccttcacgcc gatccaggtg tcgggcccga
3394261 tccgcaccgg actcttgatg atgccctggt ctttgatcgg cagcgtgatg tcgtccatcc
3394321 ggtggtcgaa atcgcagata tagcaccagt cggccattag caccgagtcc ccgatctcga
3394381 tgtcgagata ggtgttgatg acgttgtccc ggcccagcac caccttgtcg ccgaaccgca
3394441 gcgagccctc gtgggcacgg atcgtgttct tgtccccgat gtgcacccag cggccgatct
3394501 ccagttgcgc tagttccggt gtcgcgtgga tctccacacc cttgccgaga aacaccatgc
3394561 cgcgggtgat gatgtgcggg ttggccagct tgaacctcaa cagccgccag tagcgcacca
3394621 ggtaccacgg agtgtaggcg cggttggcaa gcacccattt cagcgatgcc agcgtgagga
3394681 acttggcctg acgtgggtcg cgcagccgcg atcctcgcca cctgcggtga agcggagcac
3394741 cccacatggt tgtcattggc gcagagctta gcttagctgt cggacctgtt tgggcgtatc
3394801 ggcgcatctg agaatgcgca tcggcgcgcg aggtgacgcc ggtggccgcc cccgcggggg
3394861 cggtgatcgg cacccggccc cacaccacac ccgatgacga gcccaaactg aggacgttca
3394921 cgacacttac accacgtaca cgacacgccc acggacaacc gggaaccgcc accggccaag
3394981 gacgcgagga accgaatctc gcccgccttg ccagaatgta cgtggtgacc cgagccgggc
3395041 aaccattaca cagttggcca gcactgacca acttcatttg tagcggttac cctcacctgt
3395101 actcattcgg ccgggcccgc cgatgagcga cccacgtagc ggaaggatct gggaacctgc
3395161 gaaaggataa ggcgcttgcg cgacgccttc cggcggccgt tgcggccgcc gtaatcgcgg
3395221 tcgagctggg cggttgcgga agtgccgact cgtgggtaga agcggccccc gcacaaggct
3395281 ggcccgcaca atacggcgac gccgccaaca gcagctacac cacgacgaat ggcgccacca
3395341 atctcacgct gcggtggacg cgttcggtca aaggaagctt ggctgccgga ccagccctga
3395401 gcgcacgcgg gtacctcgcg ttaaacgggc agaccccggc cgggtgttcg ctgatggagt
3395461 ggcagaacga caacaacggc cggcagcgct ggtgtgtgcg gctggtccag ggcggcggct
3395521 tcgccggccc gttgttcgac ggcttcgaca acctctacgt cggccagccg ggagcgataa
3395581 tctcctttcc gccgacccag tggacgcgct ggcgccagcc cgtgatcggg atgccgtcca
3395641 ccccgcggtt tctggggcat ggccgcctgc tcgtgagtac acacctgggg cagctgctgg
3395701 tattcgatac ccgccgcggc atggtggtcg gcagtccggt ggacctggtg gacggcatcg
3395761 atcccaccga tgcgacacgc ggactggccg actgcgcgcc agcccggccg ggctgcccgg
3395821 tcgcggccgc ccctgcgttc tcgtcggtca acggcacggt ggtggtcagc gtctggcagc
3395881 cgggcgaacc ggccgcgaag ctggtcgggc tgaaatacca cgctgagcaa ctcgtccgcg
3395941 agtggaccag tgacgctgtc agcgcgggcg tgctggccag cccagtgctc tccgccgacg
3396001 gatcgacggt ctacgtcaat gggcgcgacc accggctatg ggcactcaac gccgccgacg
3396061 ggaaagcgaa gtggtcagct cccctgggct ttctggcgca gacgccgccc gcactgaccc
3396121 cacatggact gatcgtgtcc ggcgggggcc ccgacaccgc gctggcggcg ttccgggatg
3396181 ccggtgatca cgccgagggg gcctggcgac gcgacgacgt tactgcgctg tcgaccgcga
3396241 gtctggccgg caccggcgtc ggctatacgg tcatcagcgg tccaaaccac gatggcacgc
3396301 ccggtttgtc gttgctggtc ttcgatccgg ccaacggcca cacggtcaac agctatccgc
3396361 tacccggagc gaccggatat cccgtcggtg tatcggtcgg caacgaccgc cgcgtggtga
3396421 ccgccaccag cgacggccag gtctacagct tcgcacctta gattgccagc ggcggaatgg
3396481 cgctgcgcgg cacctgggct tggcaagcgc cgacaaacga cggcagcagc tcaccctggg
3396541 cgaagtagaa aatcagactg tcgtcggtga tagcaaagtt ctggtagtga gccgggtcga
3396601 ggccggtcga aggcaatatc gcggcaccga aaccggtctg acgtgccagc tcgcgctgaa
3396661 cgatggggta gatgctgtcc agtggcgtgg tgccgggcac gaacaacgtg tcgaaggtga
3396721 tgggctgcga ggtcgcgagg ttgtagttga aggccttgta ccaggtggac ggatgtgccc
3396781 caccgaggtc ctggaagaat ttgagcacta cgctgcgggt ggcctgcggc ggctggccgg
3396841 agctgtgctg ttcgctggtg gcgtccattt ggtagggctg gtctcgcagc ggggacccct
3396901 gcgcgacgtt gacgaacccg tcgcggtttt gcgtgatgta gtcggtcagc gcctgctggt
3396961 cgggatagtc gacaggaaat gtcatatcca gcatgtactt agggcccgag gcgtgcacat
3397021 ggcagatctg gccggcctgc acagtgccgc ccaggccggc gcatgacggc ggcgcaccag
3397081 ccgccggcca gcccaccagg accacagcaa cgagcactgc ggtcgctatc agataacgca
3397141 tcgtctaatc gtcctcgcag accaaaggcg ttggcgcagc ttaggggtga ccgccgccag
3397201 cctacccgtg ccgctaccgg gacggccgac acacataggc ggtcacatgg ctcaaggacc
3397261 cggcaccaat gcgggtgatg accaccgcca gcggtctgct gccccgcagc cggagccgtc
3397321 gccgcagagc gtcgggatcg atcgcaacgc cgcgcaccag gatttcggct gccccgcaat
3397381 ccagcgctga cagcacctga cgcagccgac gctcgtcgaa ggccagctgc tcgagcacct
3397441 cgaacccgcg caacgcaggc ggcagccggt caccggacag gtaagcgatt tggggatcga
3397501 gctgccacag cccatgccgg gcgccgtagt tgcgtaccag gccggcacgg acgacggcgc
3397561 cgtcggggtc gacgatccat ttcccggcgg gccgcacacc gcagtcgtcg ggctcgtcgt
3397621 caccgatttg ttcaccggaa tcgaggatgc tggctcgacg gcggataccc gatccggcca
3397681 acccggccga ccaaagacat gcttctcgaa ccccaccgcg gtatgagatc acctcgatct
3397741 cgccctcgaa accgagccgg cccacctcct cgaaatctat tccgggagcg cacttgacga
3397801 ccacatcacg gccgcggtag cggtccagta gggggcccag gccgggctgg tagtcggcga
3397861 ggtggaagcg tcgccgcccg ttgctgcgac gcgccgggtc gatgacgacg accgcgtcgc
3397921 gggtcaccgg atgcagcaca tcggcgcggc acaggtcagc ttccattccc agggcggcca
3397981 ggttgtggcg cgccatggcc agccgcaccg ggtcgatatc gctgccgacc gcccggacag
3398041 ctagctcgcg cagcgcggcc agctcggtgc cgatggagca ggtcgcgtcg tgcactaccc
3398101 gaccggccag tcgcctggcc cggtgccggg ccacgggtgc tgcggtagcc tgctgcagcg
3398161 cctcatcggt gaatagccat tgcgacaccc caacgttcgg acacagctcg cccagtttgc
3398221 cggcggcgcg gcggcgcagc agcgtggtct ccaccagcca cggcgcccga tcgccaaacc
3398281 gggcgcgcac cgcggcggtg tcggcaatgc gagtggcagc ggtcagctcg agctctgcga
3398341 ccgcggccag cgcaaccgca cccgattctg accgcagata gctgacgtcg gcggtggtga
3398401 acgtgagacc agtgaagccg ctggtcagga cggcttaacc ccggtaatca tcacgttgta
3398461 gaaccagccc ttcggcacca catgccgcca gacgttggcg tccacccagc ccagagtctt
3398521 ccagctggtg aaggcgaagc gcgcccaacc ccagcccagc cgccctggcg gcaccgtgca
3398581 ctcaaacgtg cgcaacggcc aacccagcat cgccgcggtg aactcctcgg tggcggtttg
3398641 gacctcgact gcacccgcgt tgtgcgcgat ccgctgcagg tcctggggcg tgaatgtgtg
3398701 caggtcgacc agggcctcca gcgccgcggc gcgcgaggac tcatcgagct cgccttgtgg
3398761 tcggcgccag cctctcaggc cgggcagctt ggtagcgttg gtgacgacac gccaggtcag
3398821 cgtggacagt gtgcgagcgt agccgtcgcc gacggtggtc ggctcgccgg cgaacacgaa
3398881 gcgcccgccc ggcttgagta cccgaaccac ctcccgcaac gacagctcga cgtcgggaat
3398941 gtggtgcagc accgcatgcc cgaccacgag gtcgaaagcg tcgtcgtcgt acgggatgcc
3399001 ctcggcgtcg gcgacccggc cgtcgatgtc tagccccagc gcttgcccat tgcgggtggc
3399061 gaccttgacc atgccgggtg agaggtcggt gaccgatcca cgccgggcaa cgccagcctg
3399121 gatcaagttg agcaggaaga atccggttcc acagcccagt tccagtgcgc ggtcgtaggg
3399181 cagctgcgcg atgacctcat caggcacgat cgcgtcgaac cggccgcggg cgtagtcgac
3399241 gcaacgctgg tcataagaga tcgaccactt ctcgtcgtag ttctcggctt cccagtcgtg
3399301 gtagagcacc tgggcgagct tgctgtcgtg ccgagctgcg gccacctgct cggccgtggc
3399361 atgtggattg ggagtggcgt cggcggggat gtttgaactc ctcgtcatat aggcgagcct
3399421 aacggccgcc ccggtcaccc ttgctgccac caccttgacc agcggcgaac acctcgacat
3399481 agcgccgacg ctcagcggcg atccgctcgg ccggcgccag ctcgtagacg tcgctgatcc
3399541 cggctttggc cgcggccagc gcgtgcggcg ggccgtcaag aaagcgcctc gcccaggccg
3399601 ccgcggcgtc gtaaacgtcg tcgggggcca ccatgtcgtc gatcaggccc agcgccaagg
3399661 cctcctcggc gtcgaagaag cgcccgctga acaccagctc cttggctctg ctcggaccgg
3399721 ccgcacgggt cagccgggcc attccgtcgc cgctggggat caggccggcc aggatctcgg
3399781 tcgcgccgaa tttcacgttg tcaccgctga ctcgccaatc ggcggctagg gccagcgtaa
3399841 ggccggcacc caacgcgtat ccggtgatgg cggccacggt cggcttgggg atcgccgcaa
3399901 cggcgtcgac ggcctgctgc cgaatccggg cggcggtgtc ggcctcctgc gcgctcaatg
3399961 tccgcagttc gggcatgtcg tcgccggcgg agaagatttc gtggccgcca tacaggatca
3400021 ctgcggccac gtcgtcgcgt cgccccagct cgttggccgc ggcgaccact tcccggtaga
3400081 cctggcgggt catcgcgttg gtaggcggtc gcgataggag caacatggcc aggccggcat
3400141 cctgggagcc gtcactgacc acgacgttga cgaactcggg caccgttggc gtcacagcgg
3400201 ccacccggtc gatccgcccg atctccgggc ctggttatag cggtcggaat cgaagaactc
3400261 gatctcccag ttgtcgccgt tgcgggccag ctgtggctgc accgggacga tttggcgttc
3400321 gacggccagc acgtcggcaa cggtatgacc ggccagcgag tccagttgcg tccaggtcgg
3400381 cggcagcaag aagttgcggc cggcggcgaa gtcggcgata gcgtcggctg gcaacaccca
3400441 accagcccgg tcggattcgg tgttctcgcc gtcggcgcgc tgaccttcag gtagggcacc
3400501 cacaaagaag taggtgtcgt agcgccgggt cagttcggcc tccggggtga cccagttggc
3400561 ccagggccgt agcaggtcgg atcgcagcac cagcttttcc cgctgcagga agtccgcgaa
3400621 ggacagcgtc cggtcggcca gtgcgcgacg cgcgtcgccg tacaccgagg catccgagac
3400681 gatgctgttc ggtgccgaat ggtcctgatc gaccggcccg gcgaatagca cccccgactc
3400741 ctcgaacgtc tcgcgggccg ccgcgcagac caaggcttcg gcgagatcag gctcgatgcc
3400801 gaaccgctgc gcccaccact gcggcggcgg accggcccat gcccccagcc ggcccaagtc
3400861 ggcgtcgcgg tcgcggtcgt cgactccccc gccgggaaac accattaccc cggcggcgaa
3400921 atccatcgca gcgtgccgcc gcatcaagaa gacggccaga ccggacgctg atccggcgtc
3400981 cgggtcgcgg accaacatca cggtcgccgc cggcctcggt gtaggcgggg gtaccagtgg
3401041 ctcgcgaggt gaattcatga ctgtctccga tgggctgctc ggctgcgacg ccgtcgggcg
3401101 aaatatcgcc cgtcggccac ctccagcgtg atctcctggc caaacgcggt ggacaggttc
3401161 tcggcggtca gcgcgtcggg aagcaagccc gcggcaacca cccgggcctc cgacagcagc
3401221 aggcaatggc tgaagccggg cggaatctcc tcgacgtggt gggtgaccag aaccagcgcg
3401281 ggcgcgtcag ggtcggctgc caggtcggcc agccgggcga ccaattcctc tcggccacct
3401341 aagtccaggc cggcggcggg ttcgtcgagc agcagcagct ctggatctgt catcaaagcc
3401401 cgcgcaatca gcactcgctt gcgctcgccc tccgacagtg ttccgtatgt gcggttggcc
3401461 aaatgctcag cgcccaggct ctccagcatg tcgatcgcgc ggtggtagtc gacggcctcg
3401521 tagcgctcgc gccaccggcc caacactgca tagccggcgg agacgacaag atcgcggacg
3401581 cgttcgtcgc cgggcacccg ctccgccagc gccgaggaac tgagcccgac ccgagcacgc
3401641 agttccgaga cgtcaacccg gcctagccgc tcaccgagca caaaggccac ccccgacgac
3401701 ggatgctcag ccgcggcggc aatgcgcagc aatgacgtct tgccggcccc gttggggccg
3401761 acgatcaccc agcgttcgtc gagttcgacc gcccaatcca gcgggccgac cagcgtgcgc
3401821 ccattacggc gcagggacac gtttcggaag tcgatcagca ggtcggggtc agccgcatca
3401881 gggccgccgt tgtcgagcac ccgactatcg tgccgcatgc tccgcgagca acctagtcgg
3401941 ccgggatttc gacgcgacgc accccacagt cgccggcgtc ggcggcctcg atctcaccgc
3402001 gagtcacgcc caacaagaac aacaccgtgt ccaggtacgg atggctcaac gacgcatcgg
3402061 cgacctcacg caacgccggc ttggcgttga atgctattcc cagcccggcc gcgcccagca
3402121 tgtcgatatc gttggcgccg tcgccgaccg cgacggtctg ctccatcggc accccatact
3402181 ggctcgcgaa gtcccgaagc gccttggcct tgccgggccg gtcaacaatc ggccccacga
3402241 cccggccggt aagaatgcca tcgacgattt ccagctcgtt ggacgcaacg aaatccaaca
3402301 tcaactcgcg tgcgagcggc tcgatgatcc gccgaaagcc gccggaaacc acaccgcagc
3402361 gaaaacccag acgccgcaag gtccggatcg tggtccgagc accgggcatc agttcgagct
3402421 gctcggcgac gtcgtctatc accgtcgcgg gcagccccgc caaggtggca acacgacgct
3402481 gcagcgactc ggcgaagtcc agctcaccac gcatcgcggc ctcggtgatc gcggcgacct
3402541 gtccctgggc acccgcacgg gctgccagca tctcgatgac ctcgccttgg accagagtgg
3402601 agtcgacgtc gaagacgatc aggcgtttgg tgcgccaagc caagccgtag tcctcgacgg
3402661 ccacatcgac atgctcttcg gcggccacct tggtcagggc gatctgcagc ggacccacgc
3402721 atccaggcgg caccgagacc cgcaactcca ggccggtgac cgggtagtcg gaaatgccgc
3402781 ggatgaagtc gatgttgacg ccgagtgcgg ccactcccct ggccaccgcg ctgaacgctc
3402841 cggcggtaat cgggcgtccc agcacgaaaa tggtgtgggt ggacggttgc cgaatgattg
3402901 gcagatcgtc gctgcgctcg atggcgacgt ctagacccac cccgtggatg gcggccgcga
3402961 cgtcgtcgcg cagcgcggta ccgtcggcaa cgtccagcgg gcacgacacc agcacaccca
3403021 gcgtgagccg gccccggatc accacttgtt cgacgttgag cagctcgact ccgtgctgcg
3403081 cgagcacctc gaagagcgcg gatgtcacgc ctggctgatc catgccggtg accgtgatca
3403141 gcaccgacac cttggctggc atgctcacct tcagatgggg cccaaccggt acggccccat
3403201 cagctcgaag tcaccatggc gggctcgtca tgatgacgcc cgacgtgggc ctcggcgcga
3403261 aggcgttcca ccatatgcgg gtagtgcagt tcgaacgcgg gacgctcgga gcggatgcga
3403321 ggcagctcgg tgaagttgtg ccgcggcggc ggacaacttg tcgcccactc cagcgaattc
3403381 ccgtaccccc acgggtcgtc gacggtgacc acctcgccgt agcgccagct cttgaagacg
3403441 ttccacacga acgggaacat cgacgcaccc aggatgaagg ccccgatcgt cgagacgacg
3403501 ttgagaccct ggaagccgtc ggtgggtagg tagtcggcgt agcgacgcgg cataccctcg
3403561 tcgcccaacc agtgctgcac caggaacgtg gtgtgaaaac cgatgaacgt caaccagaag
3403621 tgcagtttgc ccaaccgctc gtcgagcagc cggccggtca tcttggggaa ccagaaatag
3403681 atgccggcga aggtggcgaa cacgatcgtg ccgaacagca cgtagtgaaa gtgtgcaacc
3403741 acgaaatagc tatcggtgac gtggaagtcc agcggcgggc tggccagcag cacaccggtg
3403801 agtccgccca gcaagaaggt gaccatgaag cccaccgaaa acaacatcgg ggtttcaaag
3403861 gtcaattgcc ccttccacat ggtgccgatc cagttgaaaa acttgatccc ggtcggcacc
3403921 gcgatcagat acgtcatgaa agagaagaag ggaagcagga cggctccggt cgcgaacatg
3403981 tggtgcgccc ataccgcgac cgacaacgcg gcgatcgaca gcgtcgcata aaccagcgtg
3404041 gtgtaaccga agatcggctt gcgggaaaac accgggaaga tctccgagac gatcccgaaa
3404101 aacggcagcg cgatgatgta gacctcgggg tggccgaaga accaaaacag gtgctgccac
3404161 agcaggactc cgccattggc ggcgtcatag atgtgagctc ccagatgccg gtcggcggcc
3404221 agcccgaaca atgccgccgt gagcagcggg aacgcaatca atatcaggat ggacgtcacc
3404281 atgatgttcc aggtgaagat cggcatccgg aacatcgtca tcccgggtgc gcgcatgcac
3404341 accacggtgg tgatcatgtt gaccgcgccc aggatcgtgc ccagacccgc aacgatcaaa
3404401 cccatgatcc acaggtcgcc cccggcgccg ggcgagtgaa tggcgtcggt cagcggcgtg
3404461 taggcggtcc acccgaagtc cgcggccccg cccggagtga tgaagccggc tgccccgatg
3404521 gtggcgccaa atacgaacag ccagaacgaa aaggcgttca gccgggggaa ggccacgtcg
3404581 ggtgcgccga tctgcagcgg cagcaccagg ttggcgaaac caaacacaat cggcgtggca
3404641 tagaacagca gcatgatcgt gccgtgcatg gtgaacaact ggttgaactg ctcattcgac
3404701 aagaactgca gaccgggtgc ggccagctcg gtccgcatca acaacgccag caggccaccg
3404761 atgaagaaaa agcttatgca cgcgacgcag tacatgatgc cgatcatctt gtgatcggtg
3404821 gtggtgatca gcttgtagac caggctcccc ttgggaccgg tgcgggccgg gtaaggacga
3404881 atggcttcga gttctcccag cgggggcgct tcggctgtca acgcactcct ccaaacatcc
3404941 agcccggacc gggccaaaac ccagtattga gaggcatctt agccctcgat caggctggcg
3405001 gcaggcctgg tcctacaaac cgtcgtaaat gccagactcc gccggcgggc cgttgcagac
3405061 caacgctttc cgcccgcgcg aatcggggtc gacggctggc cgagtgctac cgtcgaacgc
3405121 gtgctgtccg gcgggatgcg atccactgtt gctgtcgccg tagcggcagc cgtgatcgca
3405181 gcgtccagtg gttgcggctc cgatcaaccg gcccataagg cgtcacaatc gatgatcacg
3405241 cccaccaccc agatcgccgg cgccggggtg ctgggaaacg acagaaagcc ggatgagtcg
3405301 tgcgcgcgtg cggcggccgc ggccgatccg gggccaccga cccgaccagc gcacaatgcg
3405361 gcgggagtca gcccggagat ggtgcaggtg ccggcggagg cgcagcgcat cgtggtgctc
3405421 tccggtgacc agctcgacgc gctgtgcgcg ctgggcctgc aatcgcggat cgtcgccgcc
3405481 gcgttgccga acagctcctc aagtcaacct tcctatctgg gcacgaccgt gcatgatctg
3405541 cccggtgtcg gtactcgcag cgcccccgac ctgcgcgcca ttgcggcggc tcacccggat
3405601 ctgatcctgg gttcgcaggg tttgacgccg cagttgtatc cgcagctggc ggcgatcgcc
3405661 ccgacggtgt ttaccgcggc accgggcgcg gactgggaaa ataacctgcg tggtgtcggt
3405721 gccgccacgg cccgtatcgc cgcggtggac gcgctgatca ccgggttcgc cgaacacgcc
3405781 acccaggtcg ggaccaagca tgacgcgacc cacttccaag cgtcgatcgt gcagctgacc
3405841 gccaacacca tgcgggtata cggcgccaac aacttcccgg ccagcgtgct gagcgcggtc
3405901 ggcgtcgacc gaccgccgtc tcaacggttc accgacaagg cctacatcga gatcggcacc
3405961 acggccgccg acctggcgaa atcaccggac ttctcggcgg ccgacgccga tatcgtctac
3406021 ctgtcgtgcg cgtcggaagc agccgcggaa cgcgcggccg tcatcctgga tagcgaccca
3406081 tggcgcaagc tgtccgccaa ccgtgacaac cgggtcttcg tcgtcaacga ccaggtatgg
3406141 cagaccggcg agggtatggt cgctgcccgc ggcattgtcg atgatctgcg ctgggtcgac
3406201 gcgccgatca actagtgagg cgcagcgcta ggctttggga tacccacagc taaaaagtta
3406261 atcaaagaaa cgaagagggt tgccatgagc actgttgccg cctacgccgc catgtcggcg
3406321 accgaacccc tgaccaagac cacgatcacc cgtcgcgacc cgggcccgca cgacgtggcg
3406381 atcgacatca agttcgccgg aatctgtcac tcggacatcc ataccgtcaa agccgagtgg
3406441 ggccaaccga attaccctgt ggtccctggc cacgagatcg ccggcgtggt gaccgccgtg
3406501 ggctcggagg tgaccaagta ccggcagggc gaccgcgttg gggttggctg tttcgtggac
3406561 tcgtgccgcg agtgcaacag ttgcacgcgc ggcatcgaac agtactgcaa gccgggcgca
3406621 aacttcacct acaactcgat cggcaaagac ggccagccaa cccagggcgg ctacagcgaa
3406681 gcgatcgtcg tcgacgaaaa ctacgtgttg cgcatacccg acgtgctgcc cctggatgtg
3406741 gcggcgccgc tgttgtgcgc gggcatcacg ctgtactcgc cactgcgcca ctggaatgcc
3406801 ggggcgaaca cgcgggtggc gatcatcggc ctaggcggac tgggtcacat gggcgtcaag
3406861 ctgggcgccg cgatgggcgc cgacgtgacg gtgctgtccc aatcgctgaa gaaaatggag
3406921 gacggtctgc gcttgggggc caagagctac tacgcgaccg ccgacccgga caccttccgc
3406981 aagctgcgcg gcggcttcga cctgatcctg aacaccgtct cggctaactt ggacctcggc
3407041 cagtacctga acctgctgga cgtcgacggc acactcgtgg aactgggtat ccccgagcac
3407101 cccatggccg tgccggcgtt cgcgctagcg ctcatgcgac gcagcctggc cgggtccaac
3407161 atcggcggga tcgccgagac ccaggagatg ctcaatttct gtgccgagca cggcgtgaca
3407221 cccgaaatcg agctgattga accggactac atcaacgacg cctacgagcg cgtgctggcc
3407281 agcgacgtgc gctaccgctt cgtcatcgac atctcagccc tgtgaggccg gtgcgcgatc
3407341 acttccggat tcggactcgc cgacgtcgac gccggccagc ggccatccgg cggcggccag
3407401 gatgcctgcc acccgttgga tgttttccgg tccggcgtcg tgatgggtca cctcggagat
3407461 gaactcggcg atctcgtcgc ggtcgatcac acggtccgcc acggcgggcg acccgttctc
3407521 ggtgaagtgg cgcaccacct ccccgatctg ctcctcggtc agcggggtgc tgcgcaatag
3407581 cgacagcagc gccacccggt ccggcccggg gacgccctcg gggtagccaa cctgaagcca
3407641 gcgcagcacc gaacggaaga aatgcgggtg cgagaacgtt ttcgtcaccc caccagtctc
3407701 aaggtttcga catcactcgc gccagtgtgg tgcggcgcga ttcagacaat tcacgaggcg
3407761 ttcaccacga tcgcgagccc atggacccat gagcccgtga cattctgcag cgtcgtctag
3407821 cgggacggca acgacgaact gggttttcac cccgctcgat ttttcacccc gctcgattag
3407881 gtggcgtttg gcaagctggc tcgcgcgctg cggggcaagg ccatctggcg ttgcgctgtc
3407941 acgcgctgga gtgccctcgt gagaaatgac cggccccggg cagcggacgt cgacggtgtc
3408001 aggccggcca gtcgccgcgg gtcaaagagc ttggcgtgac gctccaccgg tagctatcgg
3408061 attccagaag cttgggcagc caattgtccc aggtgccagt cgcgccgcca gcggtatgca
3408121 ccgcggtacg cgcggcaaca aacgccttgt gacgagcgcg tccgagcggt catcggcctc
3408181 caccgtcatg cacagctcct tctccaggtc tacgccgacg tcgcggtcca cattggtgag
3408241 cttggcgaat gcctcggcaa cctcgtcgaa atgcgcctcc gcgtccgcat cgaacggtcc
3408301 gcccatgtca aagatcaact cgacgtagta gctagttacc gcatcaggtc agtgtttgct
3408361 ggcctcggag tccggccgaa caatggccca ttttcccgcg actctagaag tcccagtcat
3408421 cgtcctcggt gacgaccgcc ttgccgatca catagctcga cccggatccg gagaagaagt
3408481 catggttctc gtcggcgttg ggtgacagcg ccgacaggat ggccgggttc acgtcggtct
3408541 catcgcgggg gaacagcgcc tcatagccga ggttcatcag cgccttgttg gcgttgtagc
3408601 gcaagaactt cttgacgtcc tcggttagcc cgacctcgtc gtagaggtcc tgggtgtatt
3408661 ccacctcgtt gtcgtagagc tcgaacagta gctcgtaggt gtagtccttg agctcggcgc
3408721 gcgtgacgtc gtcaaccaac gccagaccac gctggaactt atagccgatg tagtaaccgt
3408781 gcacggcctc gtcgcggatg atcagccgga tcatgtcggc ggtgttggtc aacttggccc
3408841 gactcgacca gtacatcggc aggtagaacc cagagtagaa caggaagctc tccagcaggg
3408901 tggaggccac cttgcgcttg agcggctcgt cgccgcggta gtactgcagc acgatctcgg
3408961 ccttgcgctg cagattgcga ttttcctccg accagcggaa ggcgtcgtcg atctcggcgg
3409021 tggaacacag cgtggagaag atctggctgt agctcttggc gtgcaccgac tccataaacg
3409081 cgatgttggt caacaccgcc tcctcatgcg gagtcagcgc gtcgggaatc aggctgaccg
3409141 caccaacggt gccctggatg gtgtccagca tggtcaggcc ggtgaagacc cgcatggtta
3409201 gttgcttctc gccggcggtc agggtgcccc acgacgggat gtcattggac accggcacct
3409261 tctcgggcag ccagaagttt ccggtcagcc gatcccagac ctcggcgtcc ttctcatctt
3409321 gcagtcggtt ccagttgatc gctgagactc gatcaattag ctttgcgttt ccagtcacca
3409381 gaaccccact tcaccaggac aacaagctgc cttgctaggc ctcaaacact acccctgggg
3409441 tccgacaagg tactgcaaca caagaagttg tgtttgcgtg tcgcgaatcc gctcgcctgt
3409501 ttcgccggct agttcgccgc agcgaccgtc gcgcggtcgc tcgacaaacc gttgccgatc
3409561 ccgaagaacc ggtactcggc ggggttgacc gagcgggtgg tcagccagta ttgccaggtg
3409621 tagccgcacc agagcacggt gttcttgccg tgctcgtcga gataccagct gcggcagccg
3409681 ccactgttcc acaccgaccc agccagcctg cgctgcagct cctggttgaa ccggtcttgc
3409741 gcctcgcggg tgggggccag cgcttgcacg cccatccggt cgcatttcgc gatcgcatcg
3409801 gccacgtaat ggatctgcga ttcgatcatg aacaccacgg agttgtgtcc cagcccagtg
3409861 ttcggcccca gcaggaagaa caggttgggc atgttggcga cggtgatccc gcggtgtgca
3409921 ccgatgccct cacggttcca gcggtcgacc aggtcctcgc cgtgacgccc cttgatctgc
3409981 acataggtat aggagtcggt gacgtggaag ccggtggcgt acacgatcac atcggcttcc
3410041 cggaagacct cacggccagt gccgtcggcg gtgacgatcc cgtcgtgcgt gatccggtcg
3410101 atgcggtcgg tgatcagttc ggtcttcggg tccgccaccg cggggtaata ggtagaggag
3410161 ttcaggatcc gtttgcagcc gatgcgatac cgcggcgtca gcttgcgccg cagctcgcga
3410221 tccttcaccg atcgacgaat attgtatttg gcataggcct cgatgatctt caacgtgttg
3410281 ggccgcttgg tcatgccgta ggccagcgcc tcctgggccc agtagatgcc gaggcgcaac
3410341 agtgcccgta gcccggggac ggttcgcaac gcccggcgca gcgacaccgg cagctcttcg
3410401 ttggtgcgcg ggaccaccca cggcggggtg cgctgataga gctgaagttc ggcgacctgg
3410461 ccgacgatct cgggcacgat ctggatcgcg ctggcaccgg tcccgacgat cgccacccgc
3410521 ttgccggtca ggtcgatact gtggtcccac tgggcggaat ggaaagcggg gccggcgaat
3410581 tcgtcgcgac ctgcgatctc ggggaaggac gggatgtgca acgcaccggc cccggagatc
3410641 aggaactgcg cgacgtattc acgcccgtcg gcggtgaaca cgtgccagcg gcattcgtcg
3410701 tcgtcccagt agccgcgatc gacgagcgaa ttgaactcga tgtagcggcg caggccgtac
3410761 ttgtcggtga cccctttgag gtagcccaag atttcgtccc agtaggaaaa caggtgtttc
3410821 cagtccgcct tgggctcgaa cgagaaggag tacaggtgcg acgggatgtc gcacgcgcag
3410881 ccggggtagg tgttgtcgcg ccaggtgccg ccgacgtcgt cggctttctc caatatgacg
3410941 aagtccactc cttgcttttg cagtgcgatg gccatgccca aaccggagaa tccggttccg
3411001 atgatgacgg cgcgggtacg taccggcggc tggttggccg ggcttggcgt ggacggcttg
3411061 gcagccgtat cggcaatgct cacaatggat cggtcttcct gttcagcggc gagtttggcg
3411121 cttcagtcac cctcgccggc gcaaataccc agtacccagg gtatcggata tgacgagtgt
3411181 tgttgattgc cgcagcgatg tcaacggccg ccgcgctcaa cgcacggcgg gattgttggg
3411241 taccgcgtcg tggatcggtt ggtcagggtc gaccgcgatg cccagcgctt cggcggtgcc
3411301 gacgatcacg cccatcatga tggtggtcag atgcgccacg aactgctcac gcggcatgcg
3411361 gcgcgggctg tcgggttcgg ggcccaacca ccactcggtt gccgatgcgg ccgatccgaa
3411421 cgccgcgaat gcggcgagtt cgagcgcggc tcgattcagc tccatctcgc gcagctcgtt
3411481 gttgaacatc tcggccatgg ccagcgtgat ctcccggcct tcgttgaggg tgcgtaccgt
3411541 cgcctcggac tgctttgccg agcggccctg aatgaacacc cgcagcacgt tggggtgctg
3411601 gtcgacgagg ttgacgtact cctcgacgct gcgccggata acttcgcggg cagagtcggt
3411661 ggctaagtcg agcgacggga agatcgccgc ccacagcatg tcacgcagtc gcatcccgat
3411721 agcctcgagc aaatcggact tgtcggtgaa atgccgatag atcttgggct tggcggtgcc
3411781 ggcctcttcg gcgatttggc gcacactcag ctcggggccc agccggtcga tagcgcggaa
3411841 cgccgcgtcg acgatttcgt tgcgcacctt cttgcggtgc tcacgccacc gttcactgcg
3411901 ggcgtcgact ttcacccccg gctttgcact ggggtggggt cgggggattc tgaccacatc
3411961 aagcacctta ccgcgttgca agcgctgacc tgggcagact ggccacgcca ggcttggttg
3412021 aatgtgaggt tcacgacgcg acacgccgcg aagccgtcgc cactttcact ctggcgcgcc
3412081 ggtgctacag catgcaggac acgcaaccct cgacctcggt gccctccaac gccatctgcc
3412141 gcagccggat gtagtacagc gtcttgatcc ccttgcgcca ggcgtaaatc tgcgccttgt
3412201 tcacgtcgcg ggtggtggcg gtgtctttga agaacaacgt cagcgaaagc ccttgatcca
3412261 catgctgggt ggccgccgcg taggtgtcga tgatcttctc gtaaccgatc tcgtaggcgt
3412321 cttcgtagta ctccaggttg tcgttggtca tatacggcgc cgggtagtag acccgcccga
3412381 tcttgccttc cttgcggatc tcgaccttcg acacgatcgg gtgaatcgac gacgtcgaat
3412441 ggttgatgta ggaaatcgac ccggtcggcg gcaccgcctg caggttctgg ttgtagatgc
3412501 cgtgcgcttg caccgactcc ttgagccgac gccagtcgtc ctgcgttggg atgcggatgc
3412561 cggcgtcggc gaacagctgg cgtaccttct gggtcttcgg ctcccaaatc tggtcggtgt
3412621 acttgtcgaa gaattccccg gacgcgtact tggaccgctc gaaacccttg aagtgcgtgc
3412681 cgcgttcgat cgcgatgcgg ttggatgccc gcaacgcgtg atacagcacc gtatagaagt
3412741 agatgttggt gaagtcgatg ccttcgtcgg atccgtagaa gatgcgttcc cgggccaggt
3412801 agccgtgcag gttcatctgt cctagcccga tcgcgtggga gtcgttgttg ccctgctcga
3412861 ttgagggcac cgacttgata tgggtttggt cgctcaccgc ggtcaacgcg cggatcgcca
3412921 cctcgatcgt ctgcgcgaag tccggcgagt ccatcgtctt ggcgatgttc agcgacccca
3412981 ggttgcacga aatgtctttg cccactttgg catacgacaa gtcctcgttg aacaatgacg
3413041 gcgtagacac ttgcaggatc tccgagcaca ggttgctgtg cgtgatcttg ccatcaattg
3413101 gattagcgcg attgacggtg tcttcgaaca tgatataggg gtagccggac tcgaactgca
3413161 gctcggccag cgtctggaag aactcccgtg ccttgatctt ggtcttgcgg atgcgcgcgt
3413221 catcgaccat ttcgtagtac ttctcggtga ccgagatgtc agcgaacggc acaccgtaga
3413281 cccgctcgac atcgtagggc gagaacaggt acatgtcatc gttgcgcttg gccaactcga
3413341 aggtgatgtc ggggatcacc acccccagac tcagcgtctt gatccggatc ttctcgtcgg
3413401 cgttctcacg cttggtgtcc aggaatcggt agatgtcggg gtgatgggcg tgcaggtaca
3413461 ccgcgccggc accttgacga gcgcccagct ggttggcgta ggagaacgca tcctccagca
3413521 acttcatgat ggggatgacg cccgaggact ggttctcgat gttcttgatc ggcgcgccgt
3413581 gctcgcgaat gttggtcagc agcaacgcca ctcccccgcc acgcttggat agctgcagcg
3413641 cggagttgat cgaccgtccg atcgactcca tgttgtcttc gacgcgaagc aaaaaacagc
3413701 tcacgggctc cccgcgctgc ttcttgccag aattcaaaaa cgtcggtgtg gcgggctgga
3413761 agcggccgtc gatgatctcg tcgaccagca gctcggcaag tgcggtatcg ccggcggcca
3413821 acgttagcgc caccatgacc acgcggtcct cgaagcgctc cagatagcgc ttcccgtcaa
3413881 aggttttcag cgtgtaggag gtgtagtact tgaacgcacc caaaaacgtc ggaaaccgga
3413941 actttttggc gtaggcgcgg tctagcagcg tcttgacgaa gttgcgcgag tactggtcga
3414001 gaacctcacg ctcgtagtaa ttctcgcgga tcaggtagtc gagcttctcg tcctgattat
3414061 ggaagaagac cgtgttctga ttgacatgct gcaaaaagta ctggtgggct gcttcccgat
3414121 ccttgtcgaa ctggatcttg ccgtccgcgt cgtacaggtt cagcatcgcg ttcagcgcgt
3414181 gatagtccgt ttcgcccggc cccccagagt aagaggcgtg cgcgccggag gctacaggct
3414241 ctgcaatgac ggttggtggc acgtctgttc cttccagaat tcagcgagac cggtgcggac
3414301 ggcggcgacg tcgtcctcgg tgcccatcag ttcgaagcgg tataggtagg gaacgctaca
3414361 ttttcgggag acgacgtcgc cggcgtagca gaactcggca ccgaagttgg tattgccggc
3414421 agcgatgacc ccgcgcagct gcgctcgatt gtggtcgttg ttcaagaagg caatgacctg
3414481 tttggggacg tatccgccgg catcgagacc cgggttggcc cggccgccac cgtaggtggg
3414541 cagtatcagc acgtacggct cgtcgacctc gatccggcca tgcagcggta tccgcgtggc
3414601 gggaataccc agtttctgca caaagcggtg ggtgttctcc gacacgctgg agaaatagac
3414661 caggctgcgc cccgcgatat ccatggcacc gcaatcttcc ttatctatgt ctgccgcgct
3414721 aggcggtcag cgctgccccg gcgagcgcct tgatgcgatc ggggcggaaa cccgaccagt
3414781 ggtcgtttcc ggcgaccacg acgggtgctt gtaggtaacc cagcgccatc acgtagtccc
3414841 gcgcttcgga atccaggctg atatcaacct tctggtaggc gatgccctgc ttgtccagcg
3414901 ccttggaggt ggcactgcac tgtacgcacg cgggcttagt gtaaacggtc acggtcatgg
3414961 gcgtaccgct cctttgcgga aatcgggaat ctgacaggat ctggcaacga ctcaagtagt
3415021 gcatcttcga tatgttgagc ggcccgacaa ggctccagat tcccgtcata gcgcgaccac
3415081 gtccgtcgac ctggcgatgc cgatgccggg aagttcatcg cgccccgtgg atctggtgag
3415141 acctggtgaa cctgggatct gccggtactc gaaaacacta cacctagggg gtggcaccta
3415201 gggggtggca cggagaagag atacaagatg ttctgaataa cattttcgaa attccctggt
3415261 cgtaagcctg gctcgagcac cgcggcggcg tgtcgcagat cacctcagcc gccgccatac
3415321 ccgtctgacc caatatatca ccggccaccg acaacgtcgc cgctagcttc ccgccgaacc
3415381 gctaccagca aagccgatgg agccgctatt ggctgacccg cctcggccca gggatcagcc
3415441 gacctcagcg gccaagttgc cgacggcgtc gcgcacattc gccgccagcc cggcgtcgtc
3415501 cgcgaccgac ttgcccagag tttggaacgg caccgacagt ttgatcgcat cgaccacccg
3415561 cgtgccagcg atgctgaacg acttgcgagt ctcgtcgtgc gcccataccc cgccgtagcg
3415621 gcccatggag ccgccgatca cggccaacgg cttgtccttc aacgcgccat cgccgaatgg
3415681 cctggacagc cagtcgatcg cgttcttgat cacggccgga atgctgccgt tgtattccgg
3415741 cgtgaccacc aaggcagcgt gcgcgtcaga cgcggcctcc cgcaacgcgc tcaccggcgc
3415801 cggcacctcc gtcgctgtgt cgatgtcttc gttgtagaac ggcaggtccc ccagcccctc
3415861 gaacatggtg acggtgacgc cgtccggagc gaccttggca gccagctcgg cgatctggcg
3415921 gttgaacgac gccgcgcgca ggcttcccac taaggccaag attttgatgt cggacttggt
3415981 atctgacact gctacgttcc tttccgcttg ttggtccacg tccttgcacg agccaaccgg
3416041 accatggtcc gatttattcc gatcgcgtta cagtgcaaag gtgagcggcg ccgagcggtt
3416101 gggtgacttg cctgtgttcg cgaggcaaga gcccgtacca gagcggggcg acgcggcacg
3416161 caatcgtgca ctcctgttgg aggcggcgcg ccgcctgatc gcccgaagcg gtgcggacgc
3416221 aatcaccatg gacgacgttg ccgcggccgc tggcgtcggc aaaggcacct tgtttcgccg
3416281 cttcggcagc cgtgccggcc tgatgatggt gttgctcgat gaagacgagc gagccagtca
3416341 gcaggccttc ctgttcggcc cgccaccgct gggcccggat gctccgccgc tggaccgcct
3416401 gatcgcattc ggtcgggagc gaatgcgctt cgtccatgcc catcaccagc tgctgtcgga
3416461 agccaaccgg gatccacaaa cccgccacag cgcggcgcta tcggtactgc gcacccattt
3416521 gcgggtactg ctggcctcgg cgccgaccac cggcgacctg gatgcccaga ccgatgccct
3416581 gctagcgctg ctcgacgtcg actatgtcga gcaccaactc aacgccggcg gccataccct
3416641 gcaaaccctg ggcgacgcat gggagagcct ggcgcgaaaa ctgtgcggac gatgatcgat
3416701 cactatgccg acagcagcac cgcgatggat cctgcacgta gacctcgacc agtttttggc
3416761 gtcggtcgaa ctgctccgcc accccgaact ggcaggtttg ccggtcatcg tcggcggcaa
3416821 cggtgatccg accgaaccgc gaaaggtcgt cacctgtgcg tcgtatgagg cccgcgccta
3416881 cggtgtgcgc gccggcatgc cgttgcggac cgccgcccga cgatgccctg aggccacctt
3416941 cttgccgtcg aacccagccg cctacaacgc ggcgtccgag gaggtggtgg cgttattgcg
3417001 cgacctggga tacccggtcg aggtatgggg ctgggacgag gcttacctcg cggtggcgcc
3417061 cgggactccc gacgacccca tcgaagtcgc cgaagagatc cgaaaagtca tcttgtcgca
3417121 aaccgggctg tcttgctcga taggtatcag tgacaacaag cagcgcgcca agatcgctac
3417181 cgggttggcg aaaccagctg gcatctatca gctcaccgat gccaactgga tggccatcat
3417241 gggtgaccgt accgtcgaag cactgtgggg tgtggggccc aagactacga aaaggctggc
3417301 aaagcttggg atcaacaccg tttaccaact tgcacacacc gattccgggc tattgatgtc
3417361 cacgttcggt ccgcgaaccg cgctgtggct gctgctggcc aaaggcggag gcgataccga
3417421 agtcagtgcc caagcttggg ttccacgctc gcgcagccac gccgtcacct ttccacgaga
3417481 cctcacctgc cgatccgaaa tggaatcggc cgtgacggaa ttggcgcagc gaacactcaa
3417541 cgaggtggtg gcttcgtcgc gaaccgtcac ccgagtcgcg gtcaccgtgc gcacggcgac
3417601 gttctacacc cgcaccaaga tccgaaagct gcaagctccc agcaccgatc ccgacgtcat
3417661 caccgctgcc gcccggcacg ttcttgacct attcgagctg gatcggcccg tccggttgct
3417721 gggagtgcgg ttagaactgg cctagaaccg gcgggcacac cgcacctggg cggcgcgaag
3417781 tcttgaccgc accggccgct atggcccggg ccgaagcgcg cgcgtgaaga acacgttgac
3417841 tcgtcgcatc accagggtgt atggccacca cgcatatcgc ttgaacgcat acagcgcccg
3417901 gatgtccgcc gacgtataga ccaggtatct gttccttgtg accccggcca aaattttgtc
3417961 ggccgccttc tccggcgtca cggcgtgacc actgaaccgt tcgacccagc ggttgaccct
3418021 cgggtcgtcg cgatccactc cggcgatctc gaccgtattg accagcgggg tcttgacggc
3418081 gccaggcacc acgaccgaca ccccgatgcc gtgccgggcc agatcgaagc gcagcacctc
3418141 agaaagtccc cgcaacccgt acttgctagc gctataggcc gcatgccacg gcaagccaac
3418201 cagcccggcc gccgaggaca cattgaccag gtgcccgccc cgaccggcgg cgaccatcgg
3418261 tgggaccaag gtctcgatga cgtggattgg gcccatgaga ttgatcgcga ccatcctgct
3418321 ccactgatcg tgcgtgagct ggtcaacggt gccccaggcc gacacaccgg cgatgtttag
3418381 taccacgtcc atgctgggat gacgggcgtg gatatcggcc gcgaatgccg ccacgtcctg
3418441 gtagtcggag acgtccagaa ctcgatgctc gggcacctga gcgccgagtg cacgggcgtc
3418501 acacacggtt tgcgccaagc catcacggtc gcggtcggtc agatacagct cggcaccttg
3418561 cgccgcgagg cgcaacgcgg tcgcgcgacc gatgccactg gccgcgccgg tgacaaagca
3418621 ccgcttaccc gcgaaatact gtccggctcc cctctgcaac atggtcgtga cgataccggc
3418681 ggtaccgaca ccccctccgg taggacgatc gatgcgcccc gatagctatg gggccttgcc
3418741 gccaccccaa agcgcgttga gccacatctg ttcaagcacc cgaacccggc gcgctgcgtc
3418801 actgtcgggg ccgacgagca aagcgtcacc ggtcagcatc agcgcggtgg tagctgccag
3418861 ggtgcggacg agcgtcggga ggtcttcgct gatcggatgc gcagtgccgg ccttcacctc
3418921 agcctcgaag acgccgatgg tttcacgcaa cagcacttgg aactgccgct cgagaatatc
3418981 gcggatctcc atgtcgctct ggcgtgccgc attacaggcc cgcagcaccg ggtcgttgtt
3419041 cgcgtaaacg gcggcgacgc tgccgatcat ccggttgacg aactgctcgg gtgactcccc
3419101 tggctgacgg gcggagaaat gctggctggc ttcttcgagt tcttcggtgg cctcggccaa
3419161 gatctgggcg agcaccgagt atttggaatc gaagtagaag tagaaaccgg agcgggctac
3419221 ccctgcgcga aggctgatag cgcgcaccga caattccgcg aacggtgtct cctccagcag
3419281 ttcgcgtgcg gcccgcagaa tcgcctggcg atgcctgtca ccacgccgtc gcatcggcgg
3419341 cgcagcctgc ttctcgtctg cggcatgact ggtcaccttt tgatcacccc cttgaccttg
3419401 caccatggcg tctgaaaacg gaacatcggt agccgtcaaa ttgaccagaa ggatagattt
3419461 cagttacagc caccaccggt aaggagcgcc aatggcgacg atccaccccc cggcatacct
3419521 ccttgaccaa gccaagcgtc gcttcacgcc gtcgttcaac aactttcccg gcatgagtct
3419581 tgtcgaacac atgctgctga acaccaaatt cccggagaag aaactcgccg aaccgccgcc
3419641 aggcagcggg ctcaagccgg tcgtcggtga cgcggggctg ccgatccttg ggcacatgat
3419701 cgagatgttg cgcggcggac cggactatct gatgttcctg tacaagacga agggtccggt
3419761 cgtattcggc gactcagctg tgctgccggg tgtcgcagca ctgggccctg acgcggcgca
3419821 ggtcatctac tccaaccgca acaaggacta ctcgcagcag ggctgggtgc ccgtgatcgg
3419881 gcccttcttc caccgcggcc tgatgctgct cgacttcgaa gagcacatgt tccaccgacg
3419941 gatcatgcag gaggcgttcg tccggtccag gctcgccggc tacctcgagc agatggacag
3420001 ggtcgtctcg cgggtggtcg ccgacgactg ggtcgtcaac gacgcacgct tccttgtcta
3420061 tccggccatg aaggcgctca cgcttgacat cgcctcgatg gtcttcatgg gccacgaacc
3420121 cggcaccgat cacgaactgg tcaccaaggt gaacaaggcg ttcacgatta ccacccgtgc
3420181 cggcaacgcg gtgatccgca ccagcgtgcc accgttcacc tggtggcgag gactgcgagc
3420241 acgcgagctg ctggaaaact acttcaccgc ccgagtcaaa gagcgccgcg aagcgtcggg
3420301 caacgacctg ctgacggtgt tgtgccagac cgaagacgac gacggcaacc ggttctccga
3420361 cgccgacatc gtcaaccaca tgatcttctt gatgatggcc gcccacgata cctcgacgtc
3420421 aacggccacg acgatggcct accagctggc cgcccacccg gaatggcagc agcgctgccg
3420481 cgacgaatcg gaccggcatg gcgatgggcc gctcgacatc gaatccctag agcagctgga
3420541 atcgctcgac ctggtgatga acgagtcgat ccggttggtg acgccggtcc agtgggcgat
3420601 gcggcagacg gtgcgcgata ccgaactgct gggctactac ctacccaagg gcaccaacgt
3420661 gatcgcatac ccagggatga atcatcgcct gccggaaatc tggacagacc cgctgacatt
3420721 cgacccggaa cggtttaccg agccgcgcaa cgagcacaag cggcaccgct atgcgttcac
3420781 gccgttcggc ggcggcgtgc acaagtgcat cgggatggtg ttcgaccaat tggagataaa
3420841 gacgatcctg caccggctgc tgcgccgcta ccggctggag ctgtcccgtc ccgactacca
3420901 gccccgctgg gactacagtg ccatgccgat cccgatggac gggatgccga tcgtgctgcg
3420961 tcccaggtag gccctcttcg gcggattccg ccaatccacc ggtgccgcag atgaaagtgc
3421021 cagtgcgcag cccgcaccca ctttcgaccc gcggcgggag tcggtctgga tcagatcccg
3421081 ccgcgggtcg cgcgaatggt cagcgtcgct atcgtgcgcc gacggtgcaa gccctttcga
3421141 cttctatgac gaccgtttga atttggacgt cccctgttgc agaaaaccct cgctgcggtg
3421201 gaacctggcg atagcatctg atgacggtgt ggaaaccgcg gaatatgggt gtgctccagc
3421261 gacgaaaggc tcaatcgatg agcgcgacta aaagcaaggg tttgcgggcg tttcagacac
3421321 tggtcgcggc gctggctgcg gtagttgcag tactagcagc gggctgcgct acccagcgcg
3421381 ttcccacggt tctgccggaa tcggagttaa ttcctcaaag cctcggttag ctgctctgcg
3421441 acctcgccgg acgggtgcag cgcaaccacg cacatgcagg agcaagaagg gcgcgaccga
3421501 tgatcgcaaa aggcaacagg cggatccggg tagggcaatt gctgggcgca gcactggtcg
3421561 ctgcttttgc cctgacagcg gtgggatgca caatccagat gcctcagcca cctctcccgc
3421621 agcaggagtt aaggcggtag gtccggcctc agggtagctg ctaactaccc gatggggcag
3421681 tcacgtcgcc gtcgggcacg gtgcggacga gcgcggacac actcatccgt actttggtgc
3421741 ttagagccac caggaagcgg cagcgtccag atggcggcgg gtgcggcaac gggccaggct
3421801 gtcgtcacca gagccgatcg cttcgagaat ccgtacgtgg gcatgtccca cagcgaccac
3421861 gtcgctccat gtcggcagcg cctgctctgt gctcgacaag tgccggcgga acagctcgac
3421921 cagtatcagc aggaacagat ccagcatcgt attgccggcc gctcgcgcca gtccgacgtg
3421981 gaaccgaaac tcctcgacgg cggccgcgcg tacatcgtcg gtggggttat ccaacctcgg
3422041 ccgccccagc gtatcgagga aggacgcaac ctcaggttcg ctgcggcgct tgacaacttt
3422101 cgcgacattg tcgatctcga tggcatcccg gacgcaccgt aggtcttcgc ggctcggctt
3422161 gcggtactgc agatagagcg cgatggtgtc gatgctggct tgtggctggg gggtggtgac
3422221 gaccaacccg ccgccgggtc cgcggcgcat gtgcgcgatc gcgtgatatt ccagcagccg
3422281 caccgcttcc cgaagcaccg cgcggctcac ctggtagcgt tccaacagcg ctgtctcggt
3422341 cccgaagacc gacccgacct gccagccgct ggcggcgata tcgtcgccaa tggtggccgc
3422401 caacacctcg gccagcttgc cgcggggcgc gcccaggatc agctgctggg cccggcgcgg
3422461 ctcacgcgcc cggcccccgt tgcggacggc cgcatcgttg ccgcgctggt gctgctgcag
3422521 ccagccggct accgcctcaa cgtgtcgttc gcttaaggtt ttggcccacg ccgaatcacc
3422581 cgccgtgacg gccgcgacga tatcggaatg ttcgttgtgc acttgaccgg ccgcctcgac
3422641 ggcctcacct gcggattggg tacctgactt ctggacgtat cgcttggtca gccgcatcaa
3422701 gatgtcgata aacagctgta ggacagggtt tttcgattgc tccgcgagca cgcggtaaaa
3422761 ctgctcaggc ggcgggggca aaccgggccg ccaccgttcc tctgcgcgca agaccgctcg
3422821 cagcctttcg atgccgggtt cgtcgatatg ctctgcggca agagaggccg ccaagggttc
3422881 gagcaccaga cgcgcgccga gcaagtcacc gatggtggtg cccaggtatt cgagatagat
3422941 gaccacggcg cgggtagcgg gcccggcatt tggctcgcag atgaacagcc cgccgttcgg
3423001 tccacgacgc attcttgcca cctgatggtg ctcaaccaga cgcacagctt cgcgcagcac
3423061 cgatcgactc acgcaaaagc gttgctgcaa agcgctttcc gaacccaagg atgctccgat
3423121 cggccagccg cggcggacga tgtccgcctc gatgcggcgg gcgatcttcg acgctcgctt
3423181 gtccgtccag accgcgtccg gctcggtgct catttcaata gagtgtactg tattggctga
3423241 gtcaagggcg cgagctgggc cctagctaat caggggatca cgcggcatgc ccaggatccg
3423301 ctcggcaatc tgattgcggg tcacctccga cgtgccgccg gcgatcgcca tgccacgggc
3423361 gcccatcacc gttcggccaa tcaccctgcc ggggccgtcc agcaacgcaa tctcgggccc
3423421 ccatagcgcg gccgcgatgg cggcgccctc gatcatgtgc tctgccactt tgagcttggt
3423481 gatgttgccc tccggaccag ggccggctcc ttcgacgctg cgagcggcac ggcgcaggtt
3423541 cagcagccgc agtgcgtgat cctctgcgag gaaagcgccg actcgaattg gggcgcccgc
3423601 aaacgcatct gaccgccgct ggaccaattg caccagcttc gccgccattg cttcgtagta
3423661 cgagccactg ccgccgatgc tgacccgctc gttgcccagc gttgcccgcg ccaccgtcca
3423721 cccggagttc ggcgccccga caacgtcctc atcggggacg aagacatcgt tgaagaacac
3423781 ctcgttgaat tccgagtcgc cggtgatctg ccgcagcggc cgcacctcga caccgggggc
3423841 caacatgtcg atgatcaccg tggtgatgcc agcgtgtttg ggggcatccg gatcggtacg
3423901 cacggtagcc aggccacgcg cgcagtactg cgctccgctg gtccacacct tttgcccgtt
3423961 gatcttccag ccgccctcca cccgagttgc gcgggtcttg accgaggccg cgtcagaccc
3424021 cgcgtcaggt tcggagaaca gttggcacca tatctcctgc tggcgcagcg ctttctcgac
3424081 gaatctttca atctgccaag gcgttccgtg ctgaatcagc gtcaagatca cccacccggt
3424141 gatcgagtaa tccgggcgct cgatgcccgc cgcgctgaac tcttcctcga tcaccaactg
3424201 ctccaccgcg cccgcggcac gaccccacgg cctgggccaa tgcggcatca catagcccgt
3424261 ctcgatcagc ttgtcgcgct gtgcatcctt ttccagagca gcgatttcag cggcgtccga
3424321 acggatgcgg gcgcgcagct cctcggcctg tgccggcagg tccaagctga tcgcccgggt
3424381 aacgccagcc gcggtgcgct cgaaaacgtc tcggacgggc gcatcaccgc cgaacaatcc
3424441 cacggtcacc aacgcccggc gcagatgcag atgcgcgtca tgctcccagg taaagccaat
3424501 accgccgtgc acctggatgt tgagctcggc attgcgtgca taggccggaa acgccagggc
3424561 cgcagcgacc gcggcggcca gccgaaactg ctcctcatcc tctgctgccg cacgcgcggc
3424621 atcccagacc gcggcgatcg ccgactcggc ggccaccagc atgttcgcgc agtgatgctt
3424681 caccgcttga aacgtggcga tggtacggcc gaattgctgt cgcaccttgg cataggccac
3424741 ggcgctgtcc acgcagtcgg ccgccccacc gacggcctcg gcggccagca atgtgcgcgc
3424801 gcgggccaaa gccgattcat acgcaccaag caggatgtcg tcggtcgtga cgcgcacgtt
3424861 gtccaggcgc acgcggccac tccgccgggt cggatcaaag ttttccggca catcaaccga
3424921 gacgcccttg cggccgcgtt ccaacaccag cacgtcgtca ccggcggcaa ccaacagcag
3424981 ctcggcaagc ccggcgccca acacgattcc cgcctcaccg tcggcaacac cgtcggtaac
3425041 ctgcacctga ctatccagtc ccacacccgc cgtcagggtt ccgtcaatca gcgccggcaa
3425101 cagccgtgcc cgttggtcat cagtaccttc tttggcgacc accgctgagg cgatcacggt
3425161 cggcacaaac agccccggtg ccaccgcacg accgagctct tcgatcacca ccacaagctc
3425221 ggacaggcca tagccagagc caccgtgtcg ctcgtcgata tgcaggccga gccagcccag
3425281 ctcggcgagg ttctgccaga acggcgggcg ggcgtccccc gccgcgtcca gtgatgcacg
3425341 cgccgcccag cgcaccttct gcgaagtcaa gaacgcgcga gccaccccgg agagctcgcg
3425401 atggtcgtcg gtcaatgcaa tacccatcaa ggcctcctag cggcactacc ggacccacat
3425461 agcccccagg cggtattggt aaagagtata ctaattgtct gtcgcggccg cgagacacgg
3425521 cttgctcggg cacgccagcc ttgccctcgc caacgatgtc ggcgagacat gccaagctga
3425581 accgtgctcc ttcacgacgt ggccatcacc tcaatggacg tggccgccac ctcgtcgcgg
3425641 ctgaccaagg tcgcgcgcat cgccgccctg ttgcaccgcg ccgcgccaga cacacagctg
3425701 gtcacgatca tcgtgtcgtg gctctccggc gagctgccgc aacgccatat cggtgtcggg
3425761 tgggcggcat tgcggtccct accgccgccc gcgccgcaac cggcgttgac cgtcaccggt
3425821 gtcgacgcca ccctctctaa gatcggcact ctaccgggca aagggtctca ggcgcagcgc
3425881 gcggcactcg ttgcggaatt gttctccgcc gcaaccgaag ctgagcaaac ctttttgttg
3425941 cgactgctcg gcggtgaact gcgccagggc gcaaagggcg ggatcatggc cgatgcggtc
3426001 gcccaggccg ccgggctccc ggccgcgacg gtccaacgcg ccgcgatgct aggcggcgac
3426061 ctggcggcag cggcggcggc cggcctgtcc ggcgcggcgc tggacacctt caccctgcga
3426121 gtgggccgac cgataggccc gatgctggca cagaccgcga ccagcgtcca tgatgcactc
3426181 gaacgtcacg gcggcacaac cattttcgag gctaaactag acggcgcgcg agtgcagatc
3426241 caccgggcaa acgaccaggt caggatctac acccgaagcc tggacgacgt cactgcccgg
3426301 ctgcccgagg tggtggaggc aacactggca ctgccggtcc gggatctagt ggccgacggc
3426361 gaggcgatcg cgctgtgccc ggacaaccgg ccgcagcgtt tccaggtcac cgcatcacgg
3426421 ttcggccgat cggtcgatgt tgcggctgcc cgcgcgacgc agccactttc ggtgttcttc
3426481 ttcgacatcc tgcatcggga tggtaccgac ttgctcgaag cgccgaccac cgagcggctg
3426541 gccgccctgg acgcactggt gccggctcgg caccgcgtgg accggctgat cacgtccgat
3426601 ccaacggacg cggccaactt cctggatgcg acgctggccg ccggccacga gggggtgatg
3426661 gccaaggcac cggccgctcg ttaccttgcg ggtcgccgcg gagcgggctg gctgaaggtc
3426721 aagccggtgc acacactcga cttggtggtg ctcgcggtgg aatggggctc gggacgccgg
3426781 cgcggcaagc tctccaatat tcacctgggc gcacgcgatc cggctaccgg tggattcgtg
3426841 atggtgggca agaccttcaa aggaatgacc gacgccatgc tggactggca gaccaccagg
3426901 tttcacgaga tcgcggtggg tccgacagac ggctacgtcg tccaacttag gcccgagcag
3426961 gtggtcgagg tagccctcga cggcgtgcaa aggtcgtcgc gctacccggg cgggctggca
3427021 ttgcggtttg cccgcgtggt gcgctaccgc gccgacaagg acccggccga ggccgacacc
3427081 atcgatgccg tgcgcgcgct ctactgatcg cacggcgaga gtgactcctg cgacgggaca
3427141 cgccggctgg gcgtcgccag attcacgctc gtcgaccaag cgggcgggac aagcagctgc
3427201 aaggatcaac ggagatcgca cccgtgattg agggaggtga cggtggcagc gccgaccccg
3427261 tcgaatcgga tcgaagaacg ctccggacac gccagctgcg tccgcgccga tgccgacctg
3427321 ccacccgtgg ccatcctcgg tcgctccccc atcacgcttc ggcacaagat cttcttcgtg
3427381 gccgttgccg tgatcggcgc tctcgcctgg accgtcgtcg cgttcttccg caacgagccg
3427441 gtcaacgcgg tctggatcgt ggtcgcagcg ggctgcacct acatcatcgg gttccggttt
3427501 tatgcgcggc tgatcgaaat gaaagtcgtc cgtccccgcg acgatcacgc caccccggcc
3427561 gaaatcctcg acgacggcac cgactacgtg cccaccgacc ggcgggtggt attcggacac
3427621 cacttcgccg ccatcgccgg tgccgggccg cttgtcggac cagtactggc cacccagatg
3427681 ggttacttac ccagcagcat ctggattgtc gtcggcgcgg tgctggccgg atgtgtccag
3427741 gactacctgg tgttgtggat ctccgtgcgg cggcgtggcc gctccctggg tcagatggtt
3427801 cgcgacgaac tcggcgccac cgccggagtg gccgccctcg ttggaatccc ggtcattatc
3427861 accattgtga tcgcggtgct ggcgctggtg gtcgtgcggg ccctggccaa gagcccatgg
3427921 ggcgtcttct cgatcgccat gaccatcccc atcgccatct tcatgggctg ctacttgcgg
3427981 ttcctacgtc ccgggcgggt gtcggaagtt tcattgatcg ggatcggact gctgctgctc
3428041 gccgttgtct ccggtgattg ggttgcccat acctcctggg gcgcagcgtg gttcagcttg
3428101 tcaccggtga cactgtgttg gcttctcatc agctatggct tcgcagcttc ggtgctgccg
3428161 gtgtggctgc tgctcgcgcc acgcgactac ctgtcaacgt tcatgaaggt cggcaccatc
3428221 gcgcttctcg cgatcggtgt ttgtgcggct cacccgatca tcgaggcccc agcggtgtcg
3428281 aaattcgccg gtagcggcaa cggcccggtg ttcgccggct cactgtttcc attcctgttc
3428341 atcaccatcg cgtgcggggc gctgtctgga ttccacgcgc tcatctgctc gggcacgacg
3428401 ccgaagatgc tggagaagga aggccagatg cgcgtgatcg gctacggcgg catgatgacc
3428461 gagtccttcg tcgccgtcat agcactactc accgcggcga tcctcgacca gcacctatac
3428521 ttcaccctca acgcgccgtc cctgcatacc cacgacagcg cagccaccgc cgccaagtac
3428581 gtcaacgggc tcggtttgac gggctcaccg gtgaccccag accacatcag ccaggccgcc
3428641 gccagcgtcg gcgaacagac gatcgtgtcg cgcaccggcg gtgcgccgac gctggcgttc
3428701 ggcatggcgg agatgctgca tcgagtggtc ggcggtgtgg gcctcaaggc gttctggtat
3428761 cacttcgcga tcatgtttga ggctctgttc atcctcacca ccgtcgacgc cggcaccagg
3428821 gccgcgcgct tcatgatctc cgatgcgctg ggcaactttg gcggtgtgct gcgcaaactg
3428881 cagaatccga gctggcgtcc cggtgcgtgg gcttgccgtt tggtggtcgt cgcggcgtgg
3428941 ggcagcatcc tgctgctcgg tgtgaccgat ccgctgggcg gcatcaacac gctgttcccg
3429001 ctgttcggca ttgccaacca gttgcttgcc ggaattgcgc tgaccgtcat caccgtcgtc
3429061 gtcatcaaga aggggcgact gaagtgggct tggataccgg gtattccact gctgtgggat
3429121 ctggcggtca ccctgaccgc atcgtggcag aagatcttct ccgctgatcc ttctgtcggc
3429181 tactggactc agcatgctca ctacgcggca gcccagcacg caggcgagac cgcgttcggc
3429241 tcggccacca acgccgatga gatcaacgac gtcgtccgga acacattcgt ccagggcacc
3429301 ctgtcgatcg tcttcgtggt ggtcgtcgtg ctggttgttg tcgccggagt catagtggcg
3429361 ctgaagacaa ttcgcggccg cggcataccg ttggccgagg acgatccggc gccgtcgacg
3429421 ttgttcgcgc ccgctggcct gattcctaca gccgcagagc gaaagttgca acgacgtttg
3429481 ggcgcgccgg cctcggcttc cgtcgcggcg cccgactagc cctcccgctg cagtggtacc
3429541 ggcgccgcaa tcagacggcg agtaggcgtg ggtccaaccc gcgattcgcg gcagccggcg
3429601 gagagggcga ccaagagacg ttatcggttc gctcggggac tcatggccgg tctgctgggc
3429661 acgatggctc tcacgagcgg cggtggtgtc gctcgcgagg atccattgga acctgatccg
3429721 ctagccccga tcatcgacga ttccaggtaa acggattcga aggcacctat agggacgtgc
3429781 cctgacgccc cgccacaatg gacgcttggg tagcctgacc agccttatgc agtgacagtg
3429841 cgtcgagcat caattgagta gatcccacca ccggtgaaca ccagcaggaa gaagccgaag
3429901 cagaacagta tcgccggagt tccgccattg ccgtccggtg gaccgccgat cggccacagt
3429961 gcatacggtt gatgcatcca gaagtaggcg accgccattt cgcccgaggc aacgaacgcc
3430021 acagcgcggg taaacagccc ggttgcgatc agcagacctg ccaccaactc gatgaccccg
3430081 gcataccagc cgggccagga tccaaattcg acgggttgag ccgaggtgac gggccagccg
3430141 aaaaggatca tcgatccgta gccggcgaac agcagcccgt ataccaaccg aaagaggctc
3430201 agcacagccg gcaaacagcc ggcgagccga cggtcgagat ctttcaccat gacacgacgt
3430261 tacggggatc gaccgcgcga acgctgggcg gattttgtct cccaccggtg tgcctactca
3430321 cgtgtggacg cacgagcctc ctttgtgtac atttgtacat gtacaaatgt acacaaagga
3430381 ggggtcttga tctacctata cctcttgtgc gcgatcttcg cggaagtggt ggcaaccagc
3430441 ctgctcaaaa gcacggaagg gttcactcgg ttgtggccca cggtgggctg tctagtgggt
3430501 tatggcatcg ctttcgcgct gctggccttg tcgatctcgc acggcatgca gacggacgtc
3430561 gcctatgcgc tgtggtcggc aatcggtacg gccgccattg tgctggtcgc cgtactgttt
3430621 ctcggctcgc cgatatctgt gatgaaggtg gttggcgtcg gcctgattgt cgtcggcgtg
3430681 gtcacgttga acctggcggg tgcccattga ccgcaggctc cgaccgccgt ccacgcgacc
3430741 cagccggtcg ccggcaggcg atcgtcgagg cggccgagcg cgtgatcgct cgccagggcc
3430801 ttggcgggct gagccaccgc agggttgccg cggaggccaa tgtaccggtc gggtcgacga
3430861 cctactactt caatgacctc gacgcgctgc gggaagccgc gctcgcgcac gccgcaaacg
3430921 cctcggccga cctgttggcg cagtggcgca gcgacctcga caaggaccgc gacctggccg
3430981 cgaccctggc ccggctcacc accgtctacc tggccgacca ggaccgctat cgcacgctca
3431041 acgagttgta catggcggca gctcatcgac cggaactgca gcgcttggcc cggctgtggc
3431101 cagatggtct actcgcgctg ctcgaaccgc gcatcggtcg acgagccgcc aacgcggtca
3431161 ccgtgttttt cgacggcgct acgctgcacg cgcttatcac cggtaccccg ctgagcaccg
3431221 atgagctcac cgatgccatc gccaggctgg ttgcggacgg cccggaacag cgcgaagtgg
3431281 gacaatctgc ccatgcggga cgaacccccg actgacaccg cagcggctcc caccaccggt
3431341 gcggcacctg agattgacac cgcccgcgaa tacgaagtaa ccgccgaata ccagtcctgg
3431401 cgggtcgtct ggggaagcgc cgcagcattg ctgacggtcg gcgtcgggat aggcgcggcc
3431461 atcctcctcg ggtggttcac gttagcgcac cggcacccgg accagcctgg ggcggccgcg
3431521 acaccacccc ctgcggggct aacaacacgg tccgcgccca ccgccgcccc gccgtcaacg
3431581 ctgcaaagcc cagacctgga cagcgtcttt cttggcaacc tgcacgatcg cggcatctcg
3431641 ttcaccaacc ccgatgccgc cgtctacaac ggcaagatgg tctgcaccaa tctcggcggc
3431701 ggcatgaccg tgcagcaggt ggtcgaggca ttgcagagta gcagccctgc acttggcgac
3431761 cggacaaccg cttacgtggc cgtctcgatt cgcacgtatt gtccgaagta cgacgctgtg
3431821 ctgccaccgg gatcctgagt ggagctaagg ggactcgaac ccctgacccc cacactgcca
3431881 gtgtggtgcg ctaccagctg cgccatagcc ccatgaagtg atgcccatcg aagctacacc
3431941 accgccggaa agcgttcaaa gccccaggtc agcgagcctc acccgatgac ccgatcgacc
3432001 acttcgcggg cggtctgctg cacctcgacc agatgttgcg gtccacggaa ggactccgcg
3432061 tagatcttgt agacgtcctc ggtgcccgac ggacgcgcgg caaaccacgc attggccgtc
3432121 gtcaccttca atccgcccag cgcagcaccg ttgccgggcg cggtcgtcag ctttgcggtg
3432181 atcggctcac cggccaactc ggtggcgctc acctggtcgg ccgacagcct ggccaggcgg
3432241 gctttctgct cccgatcggc gggcgcgtcg atccgcgcat agcacggccc accgtactcg
3432301 ccggccagcg cgtgatatcg ctgcgacggc gtagccccgg tgaccgccag gatctcggcg
3432361 gccagcagcg ccatgatgat gccgtccttg tcggtggtcc ataccgatcc gtcccgtcgc
3432421 agaaatgatg cccccgccga ttcctcgccg ccgaagccca aggtggcgcc gatcagaccg
3432481 tcgacgaacc atttgaatcc gaccggtacc tcaacgagtt gacggccgat cccggcgacc
3432541 acccggtcga tgatcgacga gctgaccacc gtcttgccca cggcgatgcc ggccggccag
3432601 gacgggcggt gggtgtagag atattcgatg gccacggcca gatagtggtt aggattcagc
3432661 agcccttcgt caggggtgac tatgccgtgt cggtcggcgt cggcgtcgtt gccggtggcg
3432721 atctggtagc gctcccggtt gccgaacatc gttcggatga gcccagccat cgcatccggt
3432781 gaactgcagt ccatccggat cttcccgtcg gtgtccaggg tcatgaaccg ccaggttgcg
3432841 tcgaccagcg gattgaccac ggtcaggtct aggccatgcc ggtgggcgat ctcaccccag
3432901 taatccacgc tggccccgcc gagcgggtcg gcgccgatcc gcaccccggc ctcgcgaatg
3432961 gcggcgatat cgaccacgtt cggcaggtca tcgacatagt ggcccaggta gtcgtgtcgc
3433021 tgggcggtgc gtaacgcgcg ggccagcggc aaccgcttca ccatcgaccg agcgagcaga
3433081 atctcgttgg cacgcttggc tattgcggtg gtcgcagcgg tgtccgccgg gccaccgttg
3433141 ggtgggttgt acttgatgcc gccgtcggac ggcgggttgt gcgacggcgt cacaacgatc
3433201 ccgtcggcca gcgcttcggt ccggccgcgg ttgtaggtca agatggcgtg gctgattgcc
3433261 ggcgtcggcg tgtagcggtc gcgggagtcg acgacggcca ccacctgatt ggcggcgagt
3433321 acctccagcg ccgataccca tgccggttcc gaaaggccat gggtgtcacg gccgatgaac
3433381 agcggcccgg tggtcccctg ggcggcgcgg tattcgacga tagcctgggt gatggccaga
3433441 atatgtagtt cgttgaacgt tccggtcagg gctgagcccc ggtgccctga ggtgccgaaa
3433501 gcgacctgtt gagcgaggtc gtcgggatcg ggttcgatcg agtagtacgc agtcaccaga
3433561 tggggcaggt cgacgaggtc ttcgggctgg gccggttgac cggctcgtgg gttggccacc
3433621 atggctacca attctgccca caggccctac agtgcgaagc gcagcattag cacaccgaga
3433681 gggatcgacc agtgccaaac cacgattatc gcgagttggc tgcggttttc gccggcggag
3433741 cgttgggtgc gctggcccga gcagcgctga gcgcactcgc catccccgac ccagcccggt
3433801 ggccatggcc gacgttcacg gtcaacgtcg tcggcgcctt cctggtgggt tatttcacca
3433861 cccggctgct ggagcgattg cccctgtcga gttatcgacg cccattgctc ggcaccggat
3433921 tgtgcggcgg actgaccact ttctcgacga tgcaggtcga gacgatcagc atgatcgaac
3433981 acggtcattg gggtttggcc gctgcctact ccgtcgtcag catcaccctc ggattgctgg
3434041 cggtgcacct ggccacggtc ttggtacgcc gagtgcggat acgccgatga cggcctcgac
3434101 ggccctgacg gtggcaatct ggatcggcgt gatgctcatc ggcggtattg ggtccgtgtt
3434161 gcgttttctg gtcgatcgct cggtggcccg ccggctggcc cggacttttc cctacggcac
3434221 actgacggtg aacatcaccg gagccgcgct gctggggttt ctggccggcc tggcgttgcc
3434281 gaaagacgca gccttactgg ccggcacggg gttcgtcggc gcctacacca ccttttccac
3434341 ctggatgcta gaaacccaac ggttgggaga ggaccgccag atggtttcgg cattggccaa
3434401 tatcgtcgtc agcgttgtgc tcggtctagc cgcggcgcta ctcggtcagt ggatcgccca
3434461 gatatgaacg agcaatgcct gaagctgacc gcgtatttcg gcgagcggca acgcgctgtc
3434521 ggcggggcgg ggaggtttct ggccgatgcg atgctggatc tgttcggctc ccataacgtc
3434581 gcgaccagcg tgatgctgcg cggtaccacc agtttcgggc caaagcacga gtttcgctgc
3434641 gatcaatcgc tgagcctgtc cgaggacccg ccggtgaccg tcgccgccgt cgacatcgaa
3434701 tcgaaaatcc gctccctggt cgacgacgtc acagcgatga ccgaccgcgg cctggtgacc
3434761 ctggaacggg cgcgactggt cacccggcac agcggcgccg aggaattcgg cgacatcgac
3434821 agccgaaacg gagatgccgc caagctcacc atctacgccg gccgccaggt gcgggttgcc
3434881 ggggcgccgg cctactacac catctgcgag cttttgcatc gacatggatt cgcaggtgcc
3434941 acagtgctgc tcggcgtcga cggcacggca cacggtcggc gccgccgggc ccggttcttc
3435001 ggccgcaacg tcaatgttcc actgatgatc attgccgtcg gaacgcctgc acaggttgcc
3435061 gtggccgcaa tggaactcac cgcagcactg cctaacccgc tgctgaccat cgaacgggtg
3435121 cggctgtgca agcgcgacgg cgagttgttc gcccgccccc aacagctgcc gcagaccgat
3435181 gaccagggac gcaccctgtg gcaaaagctc atggttcaca ccgccgaagc aacccatcat
3435241 gaggggctgc cgatccaccg agcgcttgtc catcgactga tgcagtccga aacggcgcgg
3435301 ggcgctaccg cgctgcgcgg catctggggc ttttacggcg accataaacc ccatggggac
3435361 aagctatttc agctggtgcg tagggtgccg gtgaccacga tcatcgtcga cacaccccag
3435421 gctatcgcgc gcagcttcga catcgtcgat gagctgacga actggcacgg gctggtaacc
3435481 agtgagatgg tccctgcggc cgtgtcactc accgggtcac gggatggcac gcaaaagacc
3435541 ggtgaaaccc cactggcgcg ctacgactac tgagtgccag ccgccagatt ggtcagatcc
3435601 cacgtcgggg acgcttaccc aacccgcgat gcgaacatcc atttgtcggc cagcgccgat
3435661 acccagcccg ctacgacctc aggattatcc ggtggcacct cgaccaacac caactcgtca
3435721 acgcccagtt cgcgagcaca tcgacatcac caacctgagg attagccagg gccacggcca
3435781 gccgcagttc gccacgatca cgacccgact gttgccgtcg aacgatgcga cgtcgtcgcg
3435841 ccataatgtg cgcattgcag cgacgtattc ggcggtgcgc tctgcgcgcc gctcgaatgg
3435901 cactccgagc gcgtcgaact cctccttgga ccatccgacg ccacgcctag tgtcagccgc
3435961 ctaccactca accgatccag gctcgccgct tctttggcca ctatcaccgg gttgtgctca
3436021 ggcagcagta gcacgcccgt cgcgacgtcc acccgcgacg aggcggcagc ggcgaaactc
3436081 aacgcgatca tcgggtcaag ccaatccgcc tgtgccggaa ccgcgatgac gccgtcgcgg
3436141 gagtagggat aacgcgacgc gggccggtcc accatcacga catgttcgcc gacccacaag
3436201 gtggcgaagc cacagtcgtc cgccgcaacc gcgacggcat cgacgaccgc cgggtcggcg
3436261 ccggcaccta ttccagcgcg tgcagtccca gtcacatcgc acgagcgtct cacacaggcc
3436321 aattggcatt agcggccgtt gagcaactgc gccaagacgg ccgcatggct gcgtgccacg
3436381 tggcgcgtcg cggtcaccgg ggtcacaacg ctgcgcccgg tcagcttgcg cagctcggct
3436441 agtgccgcgc tgtcgtgcag ctcctcctgg tagcgcgacg cgaattcgtc aaaccgctcc
3436501 ggctggtggt ggtaccactc gcgcagctct ttggatggtg cgacgtcttt gcaccagatg
3436561 cccacccgct ggtcatcctt gcggattccg tgcggccaga tgcgatcgac caggacacgc
3436621 tggccgtcgt cgggatcgat gtcttcatag acgcgggcca cccgcacccg tgtctcgcgc
3436681 accattgtgc cagcgtatag ccgttaccgc gggggcttat ccacagccac cggcgccacc
3436741 agttgtcccg gtctgtgcag gctgctattc tcgaacacat gttcgagaca ttgaccgcga
3436801 tcgacccgga tgccgaggaa gcggcgttga tcgagcgaat cgccgagctg gagcggctta
3436861 agtcggcagc cgcggctggc caggcgcggg cggcggccgc tgtggacgcc gcccgcagag
3436921 ccgccgaagg agctgccggg gtgccggctg cgcgccgtgg acgtgggctg gccagtgaga
3436981 ttgccctggc tcgacgagat tcaccagccc ggggcagccg gcatctgggg tttgccaagg
3437041 ccttggttta cgagatgcca cacacgctgg ccgccctgga ctgcggcgcc ctctcggagt
3437101 ggcgggccac cctgatcgtg cgcgaaagcg catgtctgga tgtcgcggac cggcgcgcat
3437161 tagatgccga gttatgtggc gaccccggcg acttggaggg gatgggcgat gcgcgggtgg
3437221 tcgcggccgc cagggcgatc gcctatcggc tggacccgca ggccgtcgtc gaccgggcgg
3437281 ccaacgccga aaatgaccgt acggtcacca ttcggccggc accggacacc atgacgtatc
3437341 tgaccgccct gttgccagtc gcccaaggcg tgtcggtgta tgcggcgctg acccgagcgg
3437401 cagacacccg ctgcgacggg cgctcccgcg gccaagtcat ggccgacacc ctggtcgaac
3437461 gggtcaccgg ccgcgacgcg gcggtcccga ccccgatcgc ggtcaacctg gtcatgtcgg
3437521 atgaaacgct gctgggtgcg gccaacacac cggcgcagct gtgcggctac ggtcccattc
3437581 ctgcggccgt ggcacggacc atggtcgcta gcgccgtcac cgaccagaga tcgcgggcca
3437641 ccctgcgcag gctctacgct catcctcagg ccggggcgct ggtgtcgatg gaatcacggg
3437701 cgcggctgtt tccccgcggt ctggccgcct tcatcgagct gcgcgatcag cgttgccgca
3437761 ccccctactg tgacgcgccg atccgacacc gcgaccatgc ccacccctgg gccgacggcg
3437821 gcccgaccag cgcgcacaac gggcttggga cctgcgaacg ctgcaactac gccaaacaag
3437881 cccccggctg gcgggtcagc acaagtgtcg acgaaaatca cacgcacaca gccgaattca
3437941 ttaccccgac aggcagtcga caccggtccg gcgccccgcc gcacctgcct gcggtcaccg
3438001 tcagcgaact cgaggtccga atcggcatcg cgctcgctcg atacgccgcc tagtagtggt
3438061 aggtgtcagt cggagccggc atgtgaaccg gttcgtcctc gaagtcggac acttcgatgc
3438121 cgtaggcgcg ggccagatcg aggatcttgg tggcccgggc aatgcgcggc aggtcagacc
3438181 cgttgcggat ctcgcccccg tcgcgggcga actcagcgaa aaattccttc gcccagacga
3438241 tttcgtcctg cgacggggat agcccctcat tcaccaccgg acattggtcc ggcgaaaggc
3438301 agatcttgcc ggtcatgcca aactcggcgg agacggccgt ggcctcgatc agcttgagcg
3438361 cgttggagcc gatggtcggc ccgtcgatcg cgctgggcag accggcggcc cgggccgcga
3438421 tggtaaagcg cgaccgcgcg taggccaatg ttgccgggtc ttcgccaaag ccggtgtccc
3438481 ggcgaaagtc gccgataccg aaggcgagcc ggaaggtgcc cttggccgca gcaatctcgt
3438541 tgatgcgctc cagaccccgc gccgtttcga ccagtgcaac gatcggcacg ttaggtagtc
3438601 gtttcgcggt ctcggtgaca tggtccaccg attcgaccat cgccagcatc actccgccaa
3438661 cggggctatc ggccaacatc gctagatcgt ccgcccacca aggtgtgccg aagccgttga
3438721 tgcgcaccca gtcagcgttt ccgtcaccaa accaacgcac ggcgttgtcc cgggcggcat
3438781 gcttgtcttt gggagcgacc gcgtcctcga tatcgagcac gacgatgtcg gcgcgtgagt
3438841 gcgcggcgga ctcgaaccgg tcgccgtgcg cgccgttgac cagtaaccaa ctccgcgcga
3438901 gaaccggatc gatacgagac ccggccaccg gatccgccgt gttggtatcg acctgttcat
3438961 acattgaggt catctagtgt ctcttcgctc agtcgatgtc gacattgttc tccttaaacc
3439021 gtagcgacgt cgcaaatcgg attggcagga tgccccgcaa aacccacgtc catggtgttg
3439081 gatggcgtgg tgtccgacac tcgccgcagc cggacgatag cggcccggca gcaaaccatc
3439141 tgggacgtcc tggccgactt tggttccttg agttcatggg tcgagggcgt cgaccactcc
3439201 tgcgtcttga accacggtcc cgacggcgga gctctaggca gcacccgccg cgtgcaggtc
3439261 ggccgcaaca cgctggtgga gcgtgtcatc gagttcgacc cacccacgac actggcctac
3439321 cgcatcgagg gcctgcccgc ccggctgcgc aaagtcacca accgctggac actacggccg
3439381 gccgatcctg taggcgcggt gacggtggtc accttgacca gcacgatcga aatcggcggc
3439441 aacccgctgg cgcgtctggc cgaacttgtc gtcggccgcg ccatggccaa gcggtccaac
3439501 acgatgctcg ccgggctggc acaacgattg gaggacaaac atggctaacc gtcccgacat
3439561 catcatcgtg atgaccgacg aggaacgtgc ggtgccgccg tacgagtcgg ccgaggtgct
3439621 cgcctggcgt caacgcagct tgaccggccg ccgttggttc gacgagcacg ggatcagttt
3439681 cactcggcac tacaccggtt cgctggcgtg cgtgcccagc cgcccgacga ttttcaccgg
3439741 ccaatatccg gatctgcacg gcgtcaccca gaccgacggc atcggcaagc gattcgatga
3439801 ttcgcggctg cgctggctac gggccggcga ggtgccgacg ttgggtaact ggtttcgcgc
3439861 ggccgggtat gacactcact acgacggcaa gtggcacatc tcgcacgccg atctggaaga
3439921 ccccgcgacc ggtgcaccac tggccaccaa cgacaacgag ggcgtcgtcg actcggccgc
3439981 ggtgcggcgt tacctcgacg ccgacccgct cgggccatac ggcttctccg ggtgggtggg
3440041 ccccgagccc catggggcgg ggttggccaa cagcggtttt cgtcgcgacc cgctggtcgc
3440101 cgatcgtgtc gtcgcgtggc tgaccgagcg ctacgcccgg cggcgcgccg gtgacaccgc
3440161 cgcgatgcgc ccgttcttgc tggtggccag cttcgtcaac ccgcacgaca tcgtgctgtt
3440221 cccggcatgg gtgtggcgca gcccgctaaa gccctcccca ctggacccgc cacacgtacc
3440281 ggcggcgccg accgccgacg aggacctgtc gaccaagccg gccgcgcagg tcgcctaccg
3440341 ggaggcgtac tactccggat acggcctaac gcgtatggtc agccgcaact atgcccgcaa
3440401 cgcgcagcgc taccgggacc tctactaccg cctgcacgcc gaggtcgacg ggccgatcga
3440461 ccgtgtgggc cgcgcggtca ccgagggcgg atccgaggat gccatgctgg tgcgcacctc
3440521 cgaccatggc gatctgctcg gagcgcatgg cggactgcac cagaagtggt tcaacctcta
3440581 tgacgaggca accagggtgc cgttcgtcat tgcccgcatc ggcgagaagg caacccaacc
3440641 gcgcacggtc tcggcgccca cctcgcatgt cgacttggtg ccgacgctgc ttagcgcggc
3440701 cggcgtggac gtagacgtgg tggccgcggc cctggccgaa tcgttctccg aggtgcatcc
3440761 gctgcccggt cgtgacctga tgccggtcgt ggacggggct tcggccgacg agggtcgggc
3440821 catctacctg atgacgcgtg acaacgtgct cgaaggcgac accggcgcgt ccctgctgtc
3440881 gcggcaactg ggccgtatcg tgaatccgcc tgcaccgctg cgcatcaagg tgcccgccca
3440941 cgtcgccgcc aacttcgagg gattagtcgt acgggtcgat gacaccgacg ccgccggtgg
3441001 tgccgggcac ctgtggaaac tggtgcgtac cttcgacgac ccggccacct ggaccgaacc
3441061 cggtgtgcgt cacctggcca ccaacggcat gggcggcgac gcctatcgca ccgatccact
3441121 ggacgaccag tgggagctct acgacctgac cgccgatccc atcgaggcat acaaccggtg
3441181 gaccgaccca caactgcacg agctgcgaca gcatctgcgg atgctgctca aacagcaacg
3441241 tgcggtatcg gtaccggaac gcaaccaacc gtggccgtat gctcatcgac tgccgccgag
3441301 cggggcatcc aacggtttgg tgcggcgagt gttgggaagg ttcgtgcgct aattgcagaa
3441361 gctgctattc accatcgggt tggccctgtt cctgatcggc ctgcttaccg gattggtcat
3441421 cccggcactg aagaacccgc gcatggcgct gtcgagccac ctcgaggggg tcctcaacgg
3441481 gatgttcctc gtcgtgctcg gcctgctctg gccgcacatc gatctgcccg aggcatggca
3441541 ggttatcgcg gtggcgctga tcgtttactc cgcctacgcc aactggctgg cgaccctgct
3441601 cgcggcggcc tggggagcgg gccgtaaatt cgcgcccatc gcgaccggcg accacaaagc
3441661 cccggccgcc aaggagggat tcgtcagctt tctgttgttg tccctctcgg tggccatcgt
3441721 gatcggcgtg gtcatcgtca tcattggcct ctgacggcga cccgtccaac tacgccagcc
3441781 gcgctagctc ggcctgaagc ttgtccagat atcgaagcgt cgggtcgcga ggctcggtcg
3441841 gcagctccag caaaacccgc tccaccccta gatgccggta tccctcaagg tctttagccg
3441901 ccgcttcacc ccactggcac acggtcaccg gcacgtcgcc cccggccatg gcgcgcaacc
3441961 gctgaagcgg acccgacagc cgctgcggtg atggactgat cgcgatccac ccggcattga
3442021 gccgggctat ccgcgggaag ttcgccggtc ccccgcccac atacagcgga ggatagggct
3442081 ttgtcaccgg cttcggccag cagtagatcg gatcgaagtc cacatatgtc ccatggaatt
3442141 ccgcctgctc ctgcgtccag atctcgatta tcgcgcgcaa ccgctcatcg atcacacgtc
3442201 cgcgcaccgc agggtccaca ccatggttgg cgacttcttc gcgcaaccag cccacaccca
3442261 cgccgaagcg aaaccgtccc tgcgacacca gatccagcga ggcgacctcc ttggccgtga
3442321 cgatcggatc gcgttccggg atcagcgcga tgccggtgcc taacaccagt gactgggtgg
3442381 tagctgccgc ggccgccaac gccacaaagg gatccagggt gcggtaatac ttctccggaa
3442441 ttgggccacc gcccgggtag gggctctgcg tgttgacggg aatatgggtg tgctcggcga
3442501 ggaacagcga ctcaaacccg cggtgctcga gtgccgcacc cagctccgcc gggccgattc
3442561 cctcgtcggt gacgaacgtc aggacaccga attgcatgct tgctcccatc gtcttgtggc
3442621 tgcaagatct gcacgacgat acggccggcc gcgagttagg ccagtcccgc atcgaccagc
3442681 agacgtgaca gcccgagttc ggcgcacttc gtggctaccg gcgccagttc gtttcgcgca
3442741 tcggattccc gtccggtggc ggcaagcgtt tcgatatgaa gtatttgcgc ctgcagcgcc
3442801 gccagcggtc tgcgcgtacc gtcgatggcg gcggcgagag caccggcccg ttggcaggct
3442861 tggtcacgat cggcggagtc gccggcggac aacaggcgca ccgcggagtc ctcgtcgagt
3442921 tcggctgtca tggtggcgat tccattgtcg cgggggatgg tgcggggtgc cagcaaatcg
3442981 gcggccaccg ccgcaggtag cgcgatgccc agccggatcc gctcgttgtt gattcgggca
3443041 gccaggcgcg gcagccccag ctggacggca gtatcgcctc cggtggacag gcgatcagcc
3443101 gcaccctcat gatccccctg ggccgccttg acccgcgcgc cgatcacgta cctggcggcc
3443161 aggtagtcca ctgcaccccc ctcggaaccc agcagatagc tctcgtccat gagacgacca
3443221 gccccggcca gatcgccggt ctcgtagagc aattcggcga gcagcgaacc cgcaagccgc
3443281 gccgcgtgcg agtgggcccc cactgccgtg ccgacctcga acgccgttcg gaagttctgt
3443341 agcgcagcga caatgtcgag ccgattcctg gccgccatgc cgcgcaagca ctgcgcataa
3443401 acggtgccga acggtcccat catttcctgg tagggcgcgg cccagtccag cagtggatat
3443461 acctcggcga actcgaagcg gcagatcgcg gccaacgccg cggtgttgcc ggcggtcccg
3443521 gggactcgcg ggggcagggt gtccggtctc gacattgcct cggcgagaag gtcatccacg
3443581 cgctcgaccc ggtctgcgaa cacctcggcg accgcccgca acacgtctgc ctcggcccgc
3443641 agatccgcct gcgtcgcctc gggaagctcg gcccggccaa gggccgtttc gaaacgattc
3443701 agggcaccgg tggccggcgc cggccgttgc agcagaatgt tcgcccacgc gatggcgagt
3443761 tggagccggg cccgtgaaac caccatcgac gtcggcagtt tctgcacgat tgccagaagt
3443821 gtggtcatct ttgactgctc cggcaggttc gtttcatcct gctcgacaag atcgacggcg
3443881 cgcgcgggat cgcccgcggc cagtgcatgg tcgacggctt cgtgcaggta gccgttctcg
3443941 gcgaaccagg ccgatgccct gcggtgcagt tccgccaccc ggtgcgaccc gccacgttcg
3444001 aggcgacggt ggagaaagtc ggcgaacatt tggtggaagc gaaaccaatt cgggtcgtct
3444061 tcggtccgtt gcaggaacaa gccgcggtgc tcggcctctt ccagcatcgc ccgcccattg
3444121 gtgatcccgg ccagcgccga ggccagcccg ccgcacgtgc gttcggtgac cgatgccacc
3444181 agtaggaatt cgcgcagttc gggttccagg gtgtccagca cgttttcgct caggaattcg
3444241 tggatcacgt cactggcgcc ggaaagtccg cgcaggagtt gggtcgcgtc gcccccgccg
3444301 cgcagcgaca gcgcggccag ccgcagcgcc gcggcccacc cgtcggtaga ggtagtcagc
3444361 gcctgcacgt ctgcgcgcgg caatcgcaga ccaccagcat cgttcagcag cgcggcggcc
3444421 tcgtcggtat cgaagcgcaa agcagccgaa tcgatctcgg ctagttcgtc gccgatccgc
3444481 aacctgccca ccggcaaacc ggcgcgagac cagctggtca cgatgagctg caggtggtga
3444541 catccgttgt ccagcaggaa acccagggca gcttgggtgc ggctgtcgga cacccgatgc
3444601 cagtcgtcga tcaccaccgc gatccggtcg tcgttttcgt ggatttcgtc gatcagcgaa
3444661 gtcaacacgt agcggccggc gtcatcccca tgctcttcga gcacgtgccc caacgactcg
3444721 gccagcgtgg gccggacccg ccggatcgac tcgagcaggt gcgacaagaa ccacacctcg
3444781 ttgttgtcgt cgttgtcgat tgtcagccag gcgaccgcgg cgccgtcgcg cgagagctct
3444841 tcccgccatt gcgccgccag ggtgcttttg ccgaatcccg agggcgcgtg gatgaggatc
3444901 agccggcgcc gtccgccggc gcgcaggatg tcggtgagcc ggctgcgggt gaccagcgag
3444961 ccggtgggca ccgacggccg gtacttggtc gcgggtgtcg gaggcgtcgg gaccgtcggg
3445021 gtgccgccgc cggtatgccg atgcgccgcg tgcgcctcgg gcgagcgtcg gcgttccacg
3445081 cccagctcga cggggagggg catctcgtcg acgctgacgc cgttgcggcg ctgaacgtcg
3445141 cgaagctcct cgccaacgtc tgccgcggtc gcgggacgat ccgccggatg gcgggccatc
3445201 gcccgttcga tggcggcggc cacgtccgcg ggcagtccct gcttccgcag gtcggggatc
3445261 ggctgcgagg tgatccgcag gaactgggcg atcacccgct caccgctgcg gcgctcgtag
3445321 gcggcatggc cggtcagcgc acagaacaac gtcgcgccca gggagtacac gtcagaggcg
3445381 ggcgtcggcg atgctccttc gagaacttcc ggcgcggtga aagccgggga accggcaatc
3445441 accccggtcg ccgtctcgaa acccccggcg attctggcga ttccgaaatc ggtcagctgc
3445501 ggttccccgt agtcggtcag caggatattc cccggcttca cgtcacggtg cagggtgccg
3445561 acgcgatgcg cggcttccag cgctcccgcg agcttgacgc cgatcgacag cgtctcgcgc
3445621 cagtccagcg gcccgtgccg gcgaatcagc gtctccaacg aattcttggc gtggtagggc
3445681 atcacgatga agggccgccc acccgccaac acgcccacct gcaagacggt cacgatgtgc
3445741 gggtgcccgg aaaggcggcc catggcccgc tgctcgcgca ggaagcgctc gagattgtcc
3445801 cgatccaggt cggtgctcaa taccttgacg gcgacggcgc ggtccagcga gggctggacg
3445861 cagcggtaga cgacgccgaa tccgccgcgc ccgatctcct cgacattgtc gaatccagcc
3445921 tcaagcagtt ccgcgggaat attcgggacc aggtcccgcc gcgtcgcgtg cggatcaacg
3445981 tcggtcatcg acggtcacta tcctcggccg ggagggtatc accaccagtt tcatcgccgg
3446041 tgaccccaca ctatcgccaa gccgcggcgt cgcggctcga tacccaccgc acgcaaaagc
3446101 tccgttccca gaccaacgga gggaaggacc ggcaccagtt gacatacgag cagttcgctc
3446161 gtatgttgac gctgatgggg ccgagcgatc tgtggacggt ggaacgcgcg gcgcgccatt
3446221 ggggcgtgag cgcgtcgcgc gctcgcgcta tcctgtcgag ccgccacatt caccgggtca
3446281 gcggctaccc cgcgcaggcg atcaaggcgg tcaccctgcg ccagggtgcg cgcaccgacc
3446341 tcaaaaccgc caaccatctc gtgccggccg cacaagcgtt caccatggcc gagacgggtg
3446401 ccgcgatcgg agagaccgaa gatgagcggg cacgactgcg cattttcttc gagttcctcc
3446461 gcggcgccga tgagaccggg acatccgcgc tcgatctcat cgttgacgag cccgcgctga
3446521 tcggtgagca ccggttcgat gctttgttgg ccgcggctgc ggaatacatt tcggcgcgct
3446581 ggggccggcc tggacccttg tggtcggtga gtatcgaacg gtttctggac acggcctggt
3446641 gggtcagcga cctcccgtcg gcacgagcgt ttgccgccgt gtggacgccg gcgccgttcc
3446701 ggcgccgcgg catttaccta gatcgccacg acctcacgag cgatggagtg tgtgtcatgc
3446761 ccgaaccggt gttcaaccga accgagctcc agcgggcgtt cactgccctg gcggccaagc
3446821 tggaacgcag aggcgttgtc ggtcaggtgc acgttgtcgg cggggcggcg atgctactcg
3446881 cctacaactc ccgtgtcacc actcgcgata tcgacgcgtt gttctcaact gacgggccta
3446941 tgctcgaagc gattcgtgag gtcgctgacg aaatgggttg gccgcgaacg tggctcaaca
3447001 atcaggccag cggttacgtc tcccgcacac caggtgaagg cgcccccgtt ttcgatcacc
3447061 cattcctgca tgtcgtagcc acacccgcgc agcaccttct cgcgatgaaa gtcgttgcgg
3447121 cacgcggcgt gcgtgacggc gaagacattc gcctcctgct cgatcggctg cgaatcacca
3447181 gcgcggccgg cgtatgggag attgtcgcac gctactttcc cgccgaaacc atcaccgacc
3447241 ggtcgaggct cctcgtcgag gacctcctca accaatagca gaccactagc agtgaagccg
3447301 cggccgccgc gcgcagcacc ccagtgtcat ggattatcca tgattcgggc gtccccaatg
3447361 cgaaccgctt ctgtcagtcg gggctggggt ttcaccaccc gtttcaccga ccgctgaccc
3447421 caccataggc tcgatactgc cggggtgtca tcccaaacca gcgccggcac gaccggttga
3447481 gcgcgctctg ctcggaatag ccgagcagca ccgcgatttg gctcagatac aaccccggtt
3447541 gggcgaggta ccttgccgct tgcgcacggc gttcgcgctc gatgaggtca tggcaccgga
3447601 ggccctcggc agccaagcgc cgctgcagcg ttcgtgggtg catgtcgagt tggtcggcga
3447661 tggcctcggc gctgcattgg ccggtcggca gcaggcggcg ggccaacccg acgacccgct
3447721 cggagagcgt ggcatcgctc ggaaggtatt gggattccaa atatttcgtg gcgatgcgct
3447781 tggtttccgg atccgcatgg tcgatgggcc taccggcgag ccggtggtcc acctcgaacc
3447841 cgcaccatgt ccggccgaac cgaacggtac aacccaacgc ttcgcggtag gcggcgtcgg
3447901 tgcccagttg cgcatgtcgg aacgagaaaa cgcgcgcccg cgcctgcggt ccgcccagca
3447961 ggcggatcat ccgggcggcg ttggccatgc tcagctcgta tccctgcagc ggatagggaa
3448021 tccccggttc ggtcacctca tagccgaacc ggacgttgga ccgtgcggta gttgatgaaa
3448081 ccgtcagcgt cagggcgggc gaatggacgt agaggtagcg accgatcgcc tccagcccgc
3448141 cgaacaaggt ggcagcgttg cgcgcgatca ccgctaccgg gccgagaatg cccaggccct
3448201 gccagcgtgc aaggcgtagt ccgaagtccg ggcaatcgag ctcggcggcg ctggcctcca
3448261 gcatgcgcac gaacccggcc agcgacatga acgcgtcctc ttggtgttcg atgcccggcg
3448321 ggatgtcgaa gcgccgcaga aacggcagcg ggtccgcgcc gagctcgcgc atcaggtcgg
3448381 tgtaccccca caggttggtg gcgcggatga ggctgcccag ctccatcacc tcctgtcgga
3448441 aaatgataaa aggctgtcgc aaagtgtcaa tacgtggcgg gggtcctcca ccatgctgga
3448501 gccatgaacc agcatttcga cgtcctgatc atcggcgccg gcctatccgg catcgggacg
3448561 gcctgtcacg tgacggccga gttccccgac aagacaatcg ccctcctgga acgacgggag
3448621 cgcctgggcg gcacctggga cttgttccgc tacccgggag ttcgttcgga ctccgacatg
3448681 ttcaccttcg gctacaagtt ccgcccgtgg cgcgacgtga aggtgctcgc cgacggcgcg
3448741 tcgatccggc agtacatcgc cgacaccgcc acggagttcg gcgtcgacga gaagattcac
3448801 tacggcctga aggtcaacac cgccgagtgg tcgagccggc agtgccgttg gaccgtcgcg
3448861 ggcgtgcacg aggcgaccgg cgaaacccgg acctacacct gcgattacct catcagctgc
3448921 accggctact acaactacga cgcgggttat ctgccggact tccccggcgt gcaccggttc
3448981 ggcggccggt gcgtgcaccc gcagcactgg cccgaagacc tcgattattc cggcaagaag
3449041 gtcgtcgtca tcggcagcgg cgcaacggcg gtcactttgg ttccggcgat ggccggctcc
3449101 aaccccggca gtgccgcgca cgtgacgatg ctgcagcgat ccccgtcgta catcttctcg
3449161 ctgccggcgg tcgacaagat ctccgaagtc ctgggccgct tcctgccgga tcgctgggtc
3449221 tacgagtttg gccgcaggcg caacatcgcc atccagcgaa agctctacca ggcctgccgg
3449281 cgctggccca agctgatgcg gcgattgctg ctgtgggagg tacgacgccg cctcggccgc
3449341 tccgtggaca tgagcaactt caccccgaac tacctgccgt gggacgagcg gttgtgcgcc
3449401 gtgcccaacg gcgatctgtt taagacgctg gcctcgggcg cggcgtcggt ggtgaccgat
3449461 cagatcgaga ccttcaccga gaagggcatc ctgtgcaagt ccggccggga gatcgaggcc
3449521 gacatcatcg tcaccgcgac cggtctgaac atccagatgc tgggcgggat gcgactcatc
3449581 gtggacggcg ccgaatacca gctgccggag aagatgacct ataagggtgt gctgctggaa
3449641 aacgccccca atctggcctg gatcatcggc tacaccaacg cgtcatggac cctgaagtcc
3449701 gacatcgccg gcgcctacct gtgccggctg ctgcggcaca tggccgacaa cggctacacg
3449761 gtggcaacgc cgcgcgatgc gcaggactgc gcgctggacg ttggcatgtt cgaccagctg
3449821 aactccggct atgtgaagcg cggccaggac atcatgccgc gccagggctc caagcatccg
3449881 tggagggtgc tcatgcacta cgagaaggac gccaagatcc tgctcgaaga ccccatcgat
3449941 gacggcgtgc tgcacttcgc cgcagcggcc caagaccacg cggcggcctg agcatcatga
3450001 acctgcgcaa aaacgtcatc cggtccgtat tacgtggtgc ccggccactg ttcgcttccc
3450061 gccggctggg tattgccggc cgtcgagtcc tgctggcgac gctgacggcc ggcgcgcgcg
3450121 cccccaaggg cacccgcttt cagcgcgtca gcatcgccgg tgtcccggtc cagcgggtgc
3450181 aaccccccca tgcggcaacc agcgggacgc tgatctacct gcacggcggt gcctacgccc
3450241 tgggcagcgc ccggggctac cgcggcctgg ccgcccagct cgcggcggcg gccggaatga
3450301 cggcgctggt ccccgactac acccgcgcac cgcacgccca ctatccagtg gccctcgaag
3450361 agatggctgc ggtgtacacc cgcttgctcg acgacgggct cgacccgaaa acgaccgtca
3450421 tcgccggtga ttcggctggc ggagggttga ccctggcgct ggccatggcg ctgcgcgatc
3450481 gcggcatcca ggccccggcc gcactcggcc tgatctgccc gtgggccgat ctcgccgtcg
3450541 acatcgaagc gacgcgaccg gcgctgcgcg atccgctcat tcttccgtcg atgtgcaccg
3450601 aatgggcgcc gcgctacgta gggtcctccg atccgcggct gcccggtatc tccccggtct
3450661 acggcgacat gagcggcctg ccgcccatcg tcatgcagac cgcgggcgac gatccgatct
3450721 gcgttgacgc ggacaagatc gaaaccgcct gcgccgcttc gaaaacaagc atcgagcatc
3450781 gccggttcgc gggcatgtgg cacgacttcc atctgcaggt cagtctgctc cccgaagccc
3450841 gcgacgcgat cgccgacctc ggggcaaggc tgcgcggcca cctccaccaa tcgcagggac
3450901 aaccacgggg agtagtcaaa tgagctcatt cgaaggcaag gtcgccgtca tcaccggggc
3450961 cggctcgggc atcggcagag cgttggcact caacctctcc gagaagcgcg caaagcttgc
3451021 cctttccgat gtcgacaccg acgggctggc caaaaccgtg cgcctggctc aagcgctcgg
3451081 cgcgcaggtg aagtcggacc ggctcgacgt cgccgaacgc gaggcggtgc tggcccacgc
3451141 cgacgccgtc gtcgcacatt tcggcaccgt gcaccaggtc tacaacaacg ccggcatcgc
3451201 gtacaacggc aacgtcgaca agtcggagtt caaggacatc gagcgcatca tcgacgtcga
3451261 cttctggggc gtcgtcaacg gcaccaaagc ctttctgccg cacgtgattg cctccggcga
3451321 cggacacatc gtcaacatct ccagcctgtt cgggctgatc gcggtgcccg ggcaaagcgc
3451381 ctacaacgcg gccaagttcg cggtgcgcgg cttcaccgag gcgctgcgcc aggagatgct
3451441 ggtcgccagg catccggtca aggtgacgtg cgtgcatccc ggcggcatca aaaccgccgt
3451501 cgcgcgcaac gccaccgtgg ccgacggcga ggaccagcag acgttcgcgg agttcttcga
3451561 ccgccggctg gcgctgcatt cgccggagat ggccgccaaa accatcgtca acggagtcgc
3451621 caagggccag gcccgcgtcg tggtcggcct ggaggccaaa gccgtcgatg tgctcgcgcg
3451681 catcatgggc tcgtcgtatc agcggctggt tgccgccggc gtcgccaagt tcttcccctg
3451741 ggccaagtag gcccatagag ttctagaaag ggacaccacg atgaaaacca ccgcggcggt
3451801 actgttcgag gcgggcaaac cgttcgagct gatggagctc gatctcgacg ggccgggtcc
3451861 gggcgaggtg ttggtcaaat acaccgccgc cgggctgtgc cattccgacc tgcacctcac
3451921 cgatggtgat ttaccaccgc ggttcccgat cgtgggcggc cacgaagggt ccggggtcat
3451981 cgaggaggtg ggtgccggcg tcaccagggt caagcccgga gaccacgtgg tgtgcagctt
3452041 catcccgaac tgcgggactt gccgctactg ctgcaccggc cggcagaacc tgtgcgacat
3452101 gggggccacc atcctggagg gctgcatgcc ggacggcagt ttccgattcc attcccaggg
3452161 aacagatttc ggcgccatgt gcatgctggg cacgttcgcc gagcgggcca ccgtctcgca
3452221 gcattcggtg gtgaaggtgg acgactggct gccactggaa accgcggtgc tggtgggctg
3452281 cggcgtgccg tccggttggg gcaccgcggt caatgccgga aacctgcggg ccggcgacac
3452341 cgccgtcatc tacggcgtcg gcggcctggg catcaacgcg gtccagggcg cgaccgccgc
3452401 cggctgtaag tacgtcgtgg tggtggaccc ggtggctttc aagcgcgaga ccgcgctcaa
3452461 gttcggcgcc acccatgcct tcgccgacgc cgccagcgcg gcggccaagg tcgacgaact
3452521 cacctggggg cagggcgccg acgcggcgct gatcctggtg ggcaccgtcg acgacgaggt
3452581 ggtctcggcc gcgaccgcgg tgatcggcaa gggcggcacc gtcgtcatca ccgggctggc
3452641 ggacccggcc aaactcaccg tgcacgtctc cggaaccgat ttgacgctgc acgagaaaac
3452701 gatcaagggc tcgctgttcg gttcctgcaa tccgcaatac gacatcgtgc ggctgctgcg
3452761 cctctacgac gccggccagc tgatgctgga cgaactcgtg accaccacct acaacctcga
3452821 acaggtgaac cagggctacc aggatctgcg ggacggcaag aacattcggg gcgtgatcgt
3452881 gcactgacca gcttccacca accacgaatc cagagaggac gatgatgcgc aggctcaacg
3452941 gcgttgacgc gctgatgctg tatctcgacg gcggcagcgc ctacaaccac accctcaaga
3453001 tcagcgtgct cgacccgtcg accgacccgg acggctggtc gtggccgaag gcgcggcaga
3453061 tgttcgagga gcgcgcccac ctgcttccgg tcttccggct gcggtacctg cccacaccgc
3453121 tgggcctgca tcacccgatc tgggtcgagg atcccgaatt cgacctcgac gcgcacgtgc
3453181 gccgggtcgt ctgtcccgcc ccgggcggga tggcggaatt ctgcgcgctc gtcgagcaga
3453241 tctacgccca cccgctggat cgcgaccgcc cgctgtggca gacctgggtg gtcgagggcc
3453301 tcgacggcgg ccgcgtcgcc ctggtcacgc tgctgcacca cgcctactcc gacggcgtcg
3453361 gcgtgctgga catgctcgcc gcgttctaca acgacacgcc tgacgaggcc cccgtggttg
3453421 cgcccccgtg ggagccgccg ccgctgccgt ccacccggca acgcctcggt tgggccctgc
3453481 gggacctgcc ctccaggctc ggcaagatcg cgccgaccgt gcgggccgtt cgtgatcggg
3453541 tgcgcatcga acgggagttc gccaaagacg gcgaccggcg cgtcccgccc acgttcgacc
3453601 gctccgcacc gccgggcccg tttcagcgcg ggctgtcgcg cagccggcgg ttctcctgcg
3453661 aatcgttccc gctcgccgag gttcgcgagg tgagcaagac gctgggcgtc accatcaacg
3453721 acgtcttttt ggcgtgtgtg gccggtgccg ttcgtcgcta tctggagcgt tgcggctccc
3453781 ctcccaccga cgcgatggtg gccacgatgc cgctcgcggt caccccggcg gccgagcgcg
3453841 cccaccccgg caactactcg tcggtcgact acgtctggct acgcgccgac atcgccgacc
3453901 cgctcgagcg gctacacgcg acccacctcg ccgccgaggc caccaagcag cacttcgccc
3453961 agaccaagga cgccgacgtc ggcgcggtgg tcgagctgct gccggaacgc ctcatctcgg
3454021 gcctggcgcg tgccaacgcg cgcaccaagg gccgcttcga caccttcaag aacgtggtcg
3454081 tgtccaacgt gccggggccg cgtgagccgc ggtatctcgg ccgctggcgc gtcgaccagt
3454141 ggttttccac cgggcagatc tcccacggcg ccacgctcaa catgaccgtc tggagctatt
3454201 gcgaccagtt caacctgtgc gtaatggccg acgcagtcgc ggttcggaac acctgggaat
3454261 tgctcggcgg cttccgcgcc tcgcacgagg agctgctcgc ggcggcccgt gcccaagcca
3454321 cgcccaagga gatggccaca tgacccgcat caatccgatc gatctgtcct tcctgctgct
3454381 ggagcgggcc aaccggccca accacatggc cgcctacacg atcttcgaaa agccgaaagg
3454441 acagaaatcg tcgttcgggc cgcgcctgtt cgatgcctac cggcacagcc aggcggccaa
3454501 gcccttcaat cacaagctga aatggctggg cacagatgtt gcggcgtggg aaaccgtcga
3454561 gcccgacatg ggctatcaca ttcgacacct cgccctgccc gcaccgggtt ccatgcagca
3454621 gttccacgaa acggtctcgt tcctcaacac cggcctgctc gataggggcc acccgatgtg
3454681 ggagtgctac atcatcgacg gcatcgagcg cggccggatc gcgatcctgc tcaaggtgca
3454741 ccacgcgctc atcgacggtg aaggcggcct gcgcgcgatg cgcaacttcc tctccgattc
3454801 accggacgac acgacgctgg ccggtccctg gatgtcggcg cagggcgccg accggccacg
3454861 gcgcaccccc gccacggtgt cgcgcagggc gcaactgcaa ggacaactgc aaggaatgat
3454921 caaggggctg accaagctgc cgagcggcct gttcggcgtc agcgcggacg cggcggacct
3454981 tggtgcgcag gcactgagcc tcaaggcgcg caaggcgtcc ctgcccttca cggcgcgacg
3455041 cactctgttc aacaacacgg cgaaatcggc ggcgcgcgcg tacgggaacg tcgagttgcc
3455101 gctcgccgac gtcaaggccc tggccaaggc gaccggcacc tcggtcaacg acgtggtgat
3455161 gacggtcatc gacgacgcgc tgcaccacta cctcgccgaa caccaggcgt ccaccgaccg
3455221 gccgctggtg gcgttcatgc cgatgtcgct gcgtgagaag tcgggcgagg gcggtggcaa
3455281 ccgggtgagc gccgaactgg tcccgatggg tgcacccaag gcgagtcccg ttgagcgcct
3455341 taaggaaatc aacgcggcga ccacacgcgc gaaggacaaa gggcgcggca tgcaaacgac
3455401 gtcccgccag gcctacgcgc tgctactgct cggcagcctg acggtggcgg acgccctgcc
3455461 cctgctcggc aagttgccga gcgcgaatgt ggtgatatca aacatgaagg ggcccaccga
3455521 gcagctctac cttgccggtg cgccgctggt ggcgttcagt ggcctgccca tcgtgccgcc
3455581 gggcgccggg cttaacgtca ccttcgccag catcaacacc gcgctgtgca tcgccatcgg
3455641 cgcggcaccg gaagccgtgc acgaaccctc ccggctggcc gaactgatgc aacgggcatt
3455701 caccgagctc caaaccgaag ccggcacaac gagtcccaca acatcgaagt cgagaacccc
3455761 atgaagaaca ttggctggat gctcagacaa cgcgcgaccg tctcgccgcg gctgcaagcc
3455821 tacgtcgagc cgtccaccga cgtccggatg acctacgcgc agatgaacgc gctggcgaac
3455881 cggtgcgccg acgtgctcac cgcgctgggg atcgccaagg gcgaccgcgt ggcattgctg
3455941 atgcccaaca gcgtcgagtt ctgttgcctg ttctatggcg cggccaagct cggcgcggta
3456001 gcggtcccta tcaacacccg cctcgccgca cccgaggtga gtttcatcct gtccgacagc
3456061 ggcagcaagg tggtgatcta cggtgcgccg tcggcgccgg tgatcgacgc catcagggcg
3456121 caggccgacc ctccgggcac ggtcaccgac tggataggcg ccgactcgtt ggccgaacgc
3456181 ctgaggtcgg cggccgcaga cgagccggcg gtcgaatgcg gcggcgatga caacttgttc
3456241 atcatgtaca cctcgggcac caccggacat cccaagggag tggtgcatac ccacgaatcg
3456301 gtgcattcgg cggccagttc ctgggcctcg acgatcgacg tgcgctaccg cgaccgcctg
3456361 ctgctaccgc tgccgatgtt ccacgtggcg gcgttgacga cggtcatctt cagcgccatg
3456421 cgcggcgtca cgctgatctc gatgccgcag ttcgatgcga cgaaggtgtg gtcactgatc
3456481 gtcgaggagc gggtctgtat cggtggcgcc gtgccggcga tcctcaactt catgcgccag
3456541 gtgcccgagt tcgccgaact cgacgcgccc gacttccgct acttcatcac cggtggcgcg
3456601 cccatgccgg aggccctgat caagatctat gccgccaaga acatcgaggt cgtgcagggt
3456661 tacgcactca ccgaatcctg tggcggcggc accctgctgc tcagcgaaga cgcgctgcgc
3456721 aaagccggct cggccggacg cgccaccatg ttcaccgacg tggccgtgcg cggtgacgac
3456781 ggcgtgatcc gcgagcacgg cgaaggcgaa gtcgtgatca agtccgacat cctgctcaag
3456841 gaatactgga atcgcccgga ggccacccgc gacgctttcg acaacggttg gttccggacc
3456901 ggcgacatcg gcgaaatcga tgatgagggc tatctttaca tcaaggaccg gctgaaggac
3456961 atgatcattt ccggcggcga gaacgtctac ccggccgaga tcgaaagtgt gatcatcggc
3457021 gttcccgggg tcagcgaggt ggcggtcatc ggcttgcccg acgagaagtg gggcgagatc
3457081 gccgccgcca tcgtcgttgc cgaccagaac gaggtcagcg agcagcagat cgtcgagtac
3457141 tgcggaacca ggctcgcacg ctacaagctg cccaagaagg tgatcttcgc cgaggccatc
3457201 ccccgcaacc cgaccggcaa gatcctcaaa acggtgctgc gcgaacagta ttcggcgacg
3457261 gtgccgaagt gatgcacggc ccgagccgct aggacggcgc gagccgcacg atgccgggaa
3457321 cgaggtagcg cgcaacgtac gcacgcagcc cctcgtcgtc atcgagcggg atcgggccct
3457381 ccggcgcagc gaccggtaat ccgttgccgt tgagtgtgtt tgagttgccc gttcatgcgg
3457441 cggcgctcgt cgatctcctc ttgcaccagg gcctcgaccg ccagccgcga gccggtgatc
3457501 cggtcgtagc ttcgggtcca gcggccgccg cggcttgtcg ccccatgcgg tttggatcac
3457561 ccgccgcgtg ctgcggctgg tgtccagcca ggcgattgcc cgcgctcgca cccgctcggc
3457621 gcgcgggttg tcggcgaccc cgaagatgac ctcggcgacg atgtcgagcg cgatcgggcc
3457681 ggcgcggtct cggaaacgga cctcctcgcc cattggccag gtggcgagcg cctttcggtc
3457741 acgcgttcca tggcccgctc gtaggacctc agcgcctttc cgcggaaggg cgggctggcg
3457801 tagcgccggt cggcgcggtg ccttccatgc tgaccagcgt gtgctcgccg aagatcgcgt
3457861 ggtgagccgg tccatcgccg gggtcagctg aaggaccgag ttgctcgccg tgaagaccct
3457921 cttcacgtct tcgggattgg gtcacgcaca gcgcgtcgac ggctccaggc acgttgaaca
3457981 ggaagcgatc aaccgagttt tgtggtgcgc gcgtaaaacc gctgggggcc agccagtatt
3458041 cggctccaaa tgcgatcgag gataggcgca cccggggcct ccatcgggac tcttcgaact
3458101 accaccgctc accttgcagt gcgactacca agcccgccga cgtgtctgcg gcgcagtatt
3458161 cttcacgcac ctggcccgcg tactccccga cccagcaaag gagtccagga atgacatggc
3458221 agatcgtgtt cgtcgtgata tgcgtgatcg tcgccggcgt cgcggcattg ttctggcgac
3458281 tcccctccga tgacacgacg cgcagccggg ccaaaacagt gacaatagcc gccgtggcag
3458341 cggcggccgt gttcttcttc ttgggctgtt tcaccatcgt tggcacccgc cagttcgcga
3458401 ttatgaccac cttcggccgt cccaccggcg taagcctgaa caacggcttc cacggcaagt
3458461 ggccctggca gatgacccat cccatggatg gtgcggtgca gatcgacaag tacgtcaagg
3458521 aaggcaacac cgatcagcgc atcacggtgc ggctgggcaa tcaatccacc gcgctggcag
3458581 acgtcagcat ccgctggcaa ctcaagcagg ccgctgcccc ggaactgttc cagcagtaca
3458641 agaccttcga caacgtgcgc gtcaacctga tcgagcgcaa cctctcggtg gcgctcaacg
3458701 aggtgttcgc cggcttcaac ccgctggacc cgcgaaacct cgacgtgtcc ccgctgcctt
3458761 cgctggccaa gcgcgccgcc gacatcctgc gccaggacgt gggcgggcag gtcgacattt
3458821 tcgatgtcaa tgtgcccacc atccagtacg accagagcac cgaggacaag atcaaccagc
3458881 tcaaccagca gcgcgcgcag acctcgatcg ccctggaagc acagcgaact gccgaggccc
3458941 aggccaaggc caacgagatc ctgtcccgct cgatcagcga cgaccccaac gtggtggtgc
3459001 agaactgcat tacggccgcg atcaacaagg gaatcagccc gctgggttgc tggccgggaa
3459061 gctcagcgct acccaccatc gcagtgccgg gacggtaacc gcgaagattg accccatgcc
3459121 gatccccttt gccgatggga tgctcagccg gctgggtcgc cgcggggcag cgctcgacct
3459181 gatcgaggag ttcgaggacg agtccgggga gccccccgca tccctgagcc ccgccgacct
3459241 gctggccgcc gaaccggccc tgctgctgca gaagatggag aaccgcctcg tccggcacca
3459301 cctagccaat ccggacgtgt tgagcggcga acagctgcgc aagctgcgct acatcctcaa
3459361 tttcgccagg ctggccgact tcgaaccggg ggccgcgggg ccgggcggaa gccgcggtcg
3459421 cggggacatc tcggtgggcg gccaagtcgc gccttggcgg tcccgggtcg tcgacgcgtt
3459481 gtacgcaccg ctgcgcgagg agcccgatcc ggtcacggcg ctggagggcg cgaaagacgt
3459541 gctggcgacg ctggtcgacg accaggacga tcagcgtcga gtgctcatcg agcgccacgg
3459601 cagcgacttc tccgcgacgg aactcgacgc cgaggtcggc tacaagaagc tggtgaccgt
3459661 cctcggcggc ggcgggggcg cgggcttcgt ctacatcggc ggcatgcaac ggctgctggc
3459721 ggccggccag gtgcccgact acatgatcgg ctcgtcgttc gggtcgatca tcggcagcct
3459781 ggtggcccgt gaactgccgg tgccgatcga cgagtacgcc gagtgggcca aaacggtgtc
3459841 ctaccgcgcc atcctgggcc cggagcggcg gcgcagccgc cacgggttgg ccggaatgtt
3459901 caccctgcgc ttcgaccagt tcgcccatac cctgctcagc cgtgcggacg gcgaacggat
3459961 gcgcatgtcg gatctggcaa tcccgttcga tgtcgtcgtc gccggtgtgc gcaggcagcc
3460021 ttatgcggcg ctgccgtcca ggttccgcca tcgcgagcgg tctacactga cgttgcggtc
3460081 gctgccgttt ctgccgatcg gtatcggccc gtgggtggcg gcacgcatgt ggcaagtcgc
3460141 ggccttcatc gacttgcggg tggtcaagcc gatcgtcatc agcgccgacg gcgcgacacg
3460201 cgacgtcaac gtcgttgacg cggcgtcttt ctcgtcggcc atccccggtg tgctgcacca
3460261 cgaaaccagc gacccgcgga tgctgccaat cctcgacgag ttgtgcgccg accaggacgt
3460321 cgcggcgatg gtcgacggcg gcgcggccag caacgtcccg gtcgaattgg cgtgggagcg
3460381 ggtccgcgac gggcggctcg gcacccgcaa cgcgtgttat ctggcgttcg actgcttcca
3460441 tccgcactgg gacccccgac atctgtggct ggtaccgatc acccaggcgg tccagctgca
3460501 gatggtgcgc aacctgccct acgccgacca cctcgtccga ttcgagccga cgctgtcgcc
3460561 ggtgaacctg gcgccgtccg cggcggccat cgaccgggct tgccggtggg ggcgcgacag
3460621 cgtcgaaccg gcgattgcgg tgacatcggc gctgctggag ccgacgtggt gggaaggcga
3460681 caggcccccc gccgccgaac ccaaggaacg cacaaagtcg gcggcctcgt cgatgagcgc
3460741 cgtgatggcc gcgattcagg cgccgacggg ccggtttcgg cgatggcgaa gccgccacct
3460801 gacctagcga cggctacagg gaacgcgacc tcggcggtcg aaagcaaacc aggtgcacaa
3460861 gtgcaacaac aacgattccg atcaccaacc cagtcgccgc gcacgccgcg gtgctgacca
3460921 accaggtcag cgcgccacca gcagacccca ccaggtggtc atctaggtgg tgaaccaggc
3460981 ggtacggggc gtgccagccg aggtggtcgc tgcccacaag cactatgtgg ccgcccaccc
3461041 agagcatggc tcccatcccg accgctgaca gcgccgatag cagtttgggc atccccgcga
3461101 ccaggccccc gccgatccgc tgcccgaatc gggacgcggt ctgggtgagg cgcaggccga
3461161 cgtcgtccat ttggacgatg acggcgacga caccgtacac cgcggcggtg atgacgaggg
3461221 cgacgatgac gaggacgatg aggcgcggca cgaatggctg gtcggccacc tcgttgaggg
3461281 cgatcaccat gatctcggcg gataggatga agtcggtccg gatcgccccg gccaccagct
3461341 cgcgttcggc gacctgcggc gcggcgtcgt ggccacggcc gccgatgacg ccgcacacct
3461401 tttcggcgcc ctcgtagcac agatacgtgg cgcccaacat cagcagcggg gtcaacagcc
3461461 acggcacgag ctggctgagc agcaatgcac cgggaaggat gagcagcagc ttgttgcgca
3461521 ccgacccgat cgcgatgcgt ttgatgatcg gcagctcacg ctcagcggtg atccggtgga
3461581 cgtattgcgg cgtcaccgcc gtgtcgtcaa tgaccactcc cgcagccttt gccgtcgcac
3461641 gaccggcggc ggcgccgatg tcgtcaatcg aggcggcggc cagccgtgca agaaccgcga
3461701 catggtccag cagtccgaac agaccgccgc tcatcgcgac tccgccatca cgatcgaggt
3461761 taccgtctgc cgtcgttgtc gccagcggtg ccgtagagcc cgccgggtcg cagcgctcgc
3461821 agagccaccc ggccccccgg gtcttcagcg gtggcgggca cgaccgcgac gcaatcggca
3461881 ccggcatccg cgtaggcgcg gagccgggcc gccactcgat cggggctacc caacgcacac
3461941 acccggtcga gcagttcgct ggggacagcg accgccagtt cgcggcgagt agcccgggac
3462001 cgcgcgctac ggaccaggcc gtcgaaaccc agcgcgctga acatttcgcc atagccgggc
3462061 ggggcgaggt acaccgccag ctgagctgcc agctgggagt gcgcggccgc accggggttg
3462121 acggcgaccg gcacgcacac cgtgaggcgc ggcgcggcac ggccggccgc ggcggctgcg
3462181 ctgtcgatcg ccgcacgaac ccgcccgaca cggaacggcg atgccaggtt gagcacgacc
3462241 tcatcggcgt gctgcgcggc caggcgaatc atgccaggtc caaacgcccc caacgcaatt
3462301 cgcgtatcgg gcgccgcacc gcgcagccgg aatccgcggc tgttgacgtg acggccgctg
3462361 tattcgaccc gcgcaccggt aaatatcgac cgcaggcatt cgatggtttc gcgcatgacc
3462421 ggcacgtggt gcgcccaagg tcggccatgc cagccggcca cgatcgccgg actggaagct
3462481 cccagcgcga ggtcaacccg acagccggtg agagaagcga ccgaactgac ccctagcgcc
3462541 agccccaccg gaccgcgaac gccgacggct agcggtccga ccttcagcgt catgtttggc
3462601 gtgcggagcc cgatcgaggt cgcgagcgcg aacgcatcgt aggtcgccat ttcgccgatc
3462661 cacagcgcag cgaaacccgt gtcagcggcc gcgagcgcga catcggttgc ctcgtggtcg
3462721 gggcggtcaa gccagaacgg tagggcgact tcgatatcgg tcatagcatc gacacgtcgg
3462781 ccggctggtc gagcaggaca cgcccgggca gttcgcgtga tgcctcgttg acctggaaat
3462841 gggcggtagc ggtgaatgcg tcgcggaacc ggcgctgcag cggtgcgttg tcgtagatgg
3462901 cggtgccgcc cgccagatca tacatgctgc gcaccacgtc ggccgaggtc cgtaccgcgt
3462961 gcgtggccgc caaccgcagc cggttgcgca tcgtcaccgg taccgcctcg gcatcgtggc
3463021 tgacctgcca ggccgcctcg attacctcgt agaacagggc gcgggcggcg cccagcgccg
3463081 actcggcggt tgccgccgcg gcttgggtcg ccgaacgttc cgccaaggtc cgagtggacc
3463141 caagcccttt cttgccgccg gccagctcga ccagatcgtc aatcgcggcg cgcgcattgc
3463201 ccaacgcagc cgcgccaatc gacaacgcga aaaatccaaa caccggaaag cgatacagcg
3463261 gccggtccac gattggtccg tcaaacaccg agaacacgcg atcagcgggc acgaagacgt
3463321 cgtcggcaac gcagtcgtgg ctgccggtgc cacgcaaacc caatgtgtgc caagtgtcga
3463381 ggacctgcag ctcgtccttg ttcagcgcga cgaccgacgg cacttgccgg tcgtcgacga
3463441 agcagccggc gaacatgatg tccgcgtggt tgatcccgct gcaaaacggc cagcgtccgg
3463501 acaccacgac accgccgtcg acggaccggg ccgtgccacg tggcgcccac acccccgccg
3463561 cgacaccccg ccccccgccg aacatttcct cgcggctgcg cgccggcagg taggcgacca
3463621 gcagggcact ggtaatcgcg atcgacacac accatcccgc tgacgcgtca ccacgcgcca
3463681 ccgcctcggc gcaccgcagc gcccgcccgg gtgccagctc cggcgccgca acctcacgcg
3463741 gcatggtggc gcgcagcaag ccggcctcgc gcagccgggt caccagctcg tctggcagcc
3463801 gacgatcgcg ctcgatttcc gcggatcgcg ctcgggccca ccgcgcgatc ttctcggcga
3463861 ggatctcgat ctcggtttcg ctttggttca cgggcggctc ctgatgacgg tggcggttca
3463921 atgaagttac cacccttggt tcagtcattg aaccaggtac agttggtgga ccatggccgt
3463981 ttccgatcta tcccaccgct tcgaagggga gtcggtcggc cgggcgctcg agctagtcgg
3464041 tgaacgctgg acgctgctta tcctgcgtga ggcgttcttc ggggtgcggc ggttcggtca
3464101 gctcgcgcgg aaccttggca ttccgcggcc cacgctgtcc tcgcggctgc ggatgctcgt
3464161 cgaggtgggt ctttttgacc gggtgccata ttcctccgac cccgagcgac acgagtaccg
3464221 gctcaccgaa gcgggccgcg atctgttcgc cgcgatcgtc gtcctcatgc agtgggggga
3464281 tgagtacttg ccacgcccag aaggaccacc gatcaagctg cgccaccaca cctgcggcga
3464341 gcacgccgac ccacgcctga tctgtaccca ctgcggcgag gagatcaccg cgcgcaatgt
3464401 gacacctgaa ccggggccgg gctttaaagc caagctggcg tcctcataac gattcccaac
3464461 ctcaaattgt tgcgaatcga taatgcaagc cgaaccacgt cgccgaacaa ggccgtacac
3464521 cttggccggg aaactatcgt cattttgtgc accgtcgaac ggccctgaag ctcccgctgc
3464581 tgctggcggc aggcacggtg ctgggccaag cgccgcgggc cgccgccgaa gaaccaggcc
3464641 ggtggtcggc cgaccgcgca catcgctggt atcaagcgca cggctggctc gtcggtgcaa
3464701 actacatcac ctcgaacgcc atcaaccagc tcgagatgtt ccagccaggc acatacgatc
3464761 cccggcgcat cgacaacgag ctgggccttg cgcggtttca cgggttcaac accgtgcgag
3464821 tcttcctcca cgacctgctg tgggcccaag acgcgcccgg tttccaaacc cggctcgcgc
3464881 agttcgtcgc catcgcggcg cgataccaca tcaaaccgct ctttgtcctg ttcgactcct
3464941 gctgggaccc gctccccaga ccgggtcggc agcgggcgcc aagggctggg gtgcacaact
3465001 ccgggtgggt gcaaagtccg ggtgctgaac gcctcgatga ccgccgctat gccagcacgc
3465061 tgtacaacta cgtcacgggt gtgttgggcc aattccgcaa cgacgatcgc gtgttgggtt
3465121 gggacctgtg gaatgaaccc gacaatcccg cgcgcgtgta tcgcaaggtg gaaaggaaag
3465181 acaagctcga gcgcgtcgcg gagctcctcc cccaagtgtt ccgatgggcc cgcacggtcg
3465241 atccggttca accgctgacc agtggtgtct ggcaagggaa ttggggagat cccggacgcc
3465301 gcagcaccat cagcgccatt caactcgaca acgccgacgt gatcaccttc cacagttacg
3465361 ccgcgccggc cgaattcgag ggccgcatcg ctgagctcgc tccgttgcag cggccaatcc
3465421 tgtgcaccga gtacctggcg cggtcccaag gcagcactgt cgagggaatc ctgccgattg
3465481 ctaagcggca caacgttggt gcgttcaatt ggggtttggt ggcgggaaag actcagacct
3465541 atttgccgtg ggattcgtgg gatcacccct accgcgcgcc cccgaaggtg tggtttcacg
3465601 acctgctaca ccccaacggc cggccgtatc gggacggcga agttcaaacg attcggaagc
3465661 tgaacgggat gccgagccag gactaggctt tccccagccc gcattgggcg cggctcgccg
3465721 aatgcgagcc cgacacctac tgaaaaccat gtgcgcggtc ggcctggcgg aaccggatca
3465781 ggcggcgata ccgagttgct ggttaatctg cggccaggac agcaaacccc agggggtgag
3465841 cagtatccag tcgtggattt gccagggggc cagtacgaag ctgaacggcg ctccttggac
3465901 tacggctgtg tgctcgagga caaccgcttg ttgtgcgagc ggatcaagcg agcccgaata
3465961 gacatacgtc ggcggaagac cgttcagcga cccatacagc ggactgacca gcgggtcgtt
3466021 gaccgcaaga ttgcctgccc acgcctggct gatctgccag gtccccacat cgagccacgg
3466081 ggacagcaac accatggacg acggtactgg gttgccctgg ctcaccatgt attgggcggc
3466141 cgccagtgcg aggttgccgc ccgcggagtc cccgaccacg ctgacgttgg agaccccgtg
3466201 ttgcgcgatt tgcgtggaga tgagcccggc catcgccggt actaccgtcc cggcagtgcc
3466261 tccttcctgc accaacgggt aaatcggcac ttgcacggtc gcgccggtct ggtaagccgt
3466321 caccgagtag ttgagccagt ggaagattga cggcggcagg ataaacgcgc cgccgtgaat
3466381 ggcaaccacg tattcgccgg ttggatgagc cggcgtgatc tgcacgacgc tcatcccgtc
3466441 ataggtggtg tactggaccg tctgtcccag cagcgagttc agcaacggcg gtggggagtt
3466501 gccaagaaac cacgacagcg gcggtatgtc gctggcaatg agcgctaaaa gtggattgtt
3466561 tgggattgca aagtgagttt cgagcgcaga caaactcagc aggggtttca ccggccacag
3466621 cgaagcgatg tcgaatccgg cagcccctga cggcgtgccg gtgaagatcc ctgcctgcgc
3466681 cgccgcgaaa ggcggaacct gcgtgaatcc ggcggccagc gccgtggggg cccgctgaat
3466741 ttcctggtga atcgtggcaa aaccgttccc gataccgctg gcgaattcac tctgcaacag
3466801 cgaagcgttg gccagctcgg cggcggcata ccccttggcc gcgcctgtca atgcctgcac
3466861 aaaccgctca tgaaacaccg caagctgtgc gctaagagct tgatagtcct gaccatggcc
3466921 ggaaaacaaa gccgcgatcg cggctgacac ctcgtcctcg gcagcggcta ataccgtcgt
3466981 ggtggcaccc gcgacaccct ggctcgccgt cgcgaccacc gaaccaatcg aagccacgtc
3467041 tgtggccgcg gcggacatca cctccggcaa cgcaacaaca taagacacca cgccgctccc
3467101 gccacctcac ggcaacttcc ccagttgccc agccactacc gatcgccgag tagccggagc
3467161 ttatgcccac gccgagtagt cacgtgccag tttgcgcgaa ttcccaaagt tagaccggca
3467221 aacgtgacgg caccgatccg tgtggtgcag ccgccgggaa tcgaacactc tccgacgcaa
3467281 aacgacctgc gattacgcgc ggggcgttga tggcgtcaag aaggaatgag gcggcgaacg
3467341 cgggcgttgg ggtgccgcta tgcgttgaac aattgctata cgattgtgca acatcagcta
3467401 tcgtcgtact catgaccgcg accatcggct tccgacctac tgaaaaagac gagcagatca
3467461 tcaacgccgc aatgcgcagc ggcgagcgca agagcgacgt catccggcgg gcactgcagc
3467521 tgctcgaacg ggaagtgtgg atcaagcaag ctcgcaccga cgctgagcga cttcgagacg
3467581 aggatgtctc cactgaaccg gacgcgtggt gattcgggga gcggtctaca gggtcgactt
3467641 cggcgatgcg aagcgaggcc acgagcaacg cgggcggcgc tacgccgtgg tcatcagccc
3467701 cggctcgatg ccgtggagtg tagtaaccgt ggtgccgacg tcgacaagcg cccaacctgc
3467761 ggttttccga ccagagctgg aagtcatggg aacaaagaca cggttcctgg tggatcagat
3467821 ccggacgatc ggcatcgtct atgtgcacgg cgatccggtc gactatctgg accgtgacca
3467881 aatggccaag gtggaacacg ccgtggcacg ataccttggt ctgtgatggc cgtcgcatct
3467941 gcaaatgggc caccgacctg gcccttcggt ggagctgccg ggaatcgaac ccgggtccta
3468001 cggcattccc tcaaggcttc tccgtgcgca gttcgctatg cctctgctcg gatctcccgg
3468061 tcacgcgaac tagccgagat gacgatccca gtcgctgtgg ttgtcccgag gagtcccgcg
3468121 accggactca tcggtggatc cctctagctg atgccagggt ccgggccgag ggcgttcccg
3468181 gtctgacaga ctagccgtcg cttaggcagc gagagcgtag tcgcgctgat gtgaatcggc
3468241 gcttatttgg tcgcaacgac gcttacggtg gtctcttgcc tgcaccggca cgcttccctt
3468301 gattcgatgc gcgaagtcga aaccgttcag cccctcgcat ccctgccgac cttcggcagg
3468361 accatcaatc ctacgccgct ctcaacaacc ggcaacgcca ttaacttccc ggtcagatca
3468421 cgaagttcag gcgctcgagg atgtgaccgg ccagctcctt gtcgccgccg agttccacat
3468481 cctggctgcg cgccgggctc atcgggcgcc cgccggcgag cctggtgaac tgcagtccgt
3468541 ccaggcggat cgtcgccgtc ggcgccggcc caccgaagtc gtcgaccacc cgcgctcgac
3468601 cgtccacgga aacgcggatg ctgcgagaca gcgggccggt cagctccaac agcacgcggg
3468661 agccgtcggg cgctttggcc agcttgccga cgacgaaccc catggtggcc gctatctcat
3468721 cgaggaccag cggtgacgcc ggcccgccga gttcgtcgtc ggacgacggg cgctgcaccg
3468781 ccgcgcggat gtcctgttcg tgcatccagc agtcgaagat gcgtatccgc atgaaccgcc
3468841 cgtagctgtc ggggcccgag ggggtggtcg tcggcgcatt ccattcgtca tcggaaaggc
3468901 tcgctaagac cttgcggcgc tggctagtca ctgcgcgaaa ccgctccagc aagcccacac
3468961 ccgattctgt gcccagatga cgcacccagc actcgttcat cacgccgatg gggttgcgga
3469021 catgcgcaag cgcagagacg tctgtgtctg gttctggtgc ggcgatgccg agcagaaatg
3469081 actcggtgcc gatgatgtgc gacaccacgg ccttgacgtc ccaaccgggc agcggactcg
3469141 ttgcctgcca gtccgtctcg agcagtccat cgagcagcgc atccagggag tgccaaacgg
3469201 cgaacagccc ggccagcacg tcggacttgt ccagtgtggt aaggggacgg cccggtgtgg
3469261 tcacaaagtg atgctaaacc tcacattgcc cagttctcga tcaggtcatg cccttagcgc
3469321 gccgacccaa ctcgcggagc acttcacgct gggcatcacg acgggccatg tcctggcgtt
3469381 tgtcgcgggc ttgcttgcct cgggccagcg caagctcaac cttgaccttg ccttcggcga
3469441 aatacagcga caacggcacc agggcgaagt tgccttcgcg gatcttgccg accaaggtgt
3469501 cgatctggcg gcgatgcaac agcagtttgc ggttgcgtcg cggctcgtgg ttggtccagc
3469561 tgccgtgccg gtattccggg atgtgcgcgt tgcgcagcca cacttcgccg tcgtcgatgg
3469621 tggcgaacga atcggccagc gacgcctgcc cttcccgcag gctcttcacc tccgtgcctt
3469681 gcagcgcaac cccggcctcg aacacctcga tgatcgaata gttgtgccgg gctttgcgat
3469741 tgctggcaac gatctgccgg ccgccacgcg acgacttgga cacagctatc gccgcacgta
3469801 gaggcgcagc gttaagtaag ccgtcaaccc cgacatcgcc acgcccaaca gcagcagcca
3469861 cggcgtgatg aagaggatgt ccgcatagtc aaccttggca atgagattgg cttgataaaa
3469921 ctggttgagc gcattctcca ggaacaaagc ccgcaccacc atcaagcccg ctacggcgat
3469981 gccgacaccc atcgtcgcgg ccagcatcgc ctccactagg aacggcagct gggtgtacca
3470041 gcggctggca ccgaccaagc gcatgatgcc gatttcggtg cgccgcgtat aggcagccac
3470101 ttggaccatg ttggcgatca acagaatcgc cccgatggcc tgaaccagcg cgaccgcgaa
3470161 cgcggcattg ctcaaaccat caaggaccgc gaacagccgg tcaatcagct ccttttgatt
3470221 cagcacgtcc aagacgccgg gctgcccctt catagcggtg tcaaagtcct tgtgctgctc
3470281 ggggttctcc agcttgacaa tgaacgacgc cgggaacgaa tccttgcccg ccacgtcctt
3470341 gaactgggga aacttgcgga tggcatcgtc ataggcctgc tggcggttaa ggaaacgcac
3470401 cgctttgacg tcggatcgcg tttcgatctt ctcccgtaac gctttgcacg cagtggtatc
3470461 gcaggacgag tcgttggcgg aaacgtcttc ggtgagaaag acctgagatt ccacccggtc
3470521 gagatagatg gcccgggagc tgtcggccaa ccggaccacc aacataccgc cgccgaacaa
3470581 tccgaccgag atcgcggtcg tcaggatcat cgcgatcgtc atggtgacat tgcgacgaaa
3470641 gccggtcagg acctcattta gcaggaaacc gaaacgcact tagcgatcca tcccgtagac
3470701 gccacgctgt tcgtcgcgta ccagcctgcc cagggacaac tcaaccaccc gttggcgcat
3470761 cgagtcgacg atgtggtggt cgtgcgtggc catcagcacc gtcgtgccgg tgcggttgat
3470821 ccgctccaat aagtccatga tgtccctact ggtctccggg tcgaggtttc cggtgggctc
3470881 gtcggccagc agtaccagcg gccggttgac aaaggcgcgg gcgatcgcaa cgcgctgttg
3470941 ctcgccgccc gacagctcgt ctggcagccg attggccttg ccggacagac cgaccgtctc
3471001 gagcacttcg gggaccaccc ggttgatcgc gtcggtgcgt ttgccgatga cctccaatgc
3471061 gaaggcgacg ttgtcgtaca ccgtcttctg ctgcagcaac cgaaagtcct ggaagacgca
3471121 gccgatcacc tgacgcagct tcggtacgtg gcgaccgcgg agtttgttga catgaaactt
3471181 cgagacccgg acatcaccac tggtcggcgt ctccgctgcc agcagcagcc gcatgaaggt
3471241 tgacttgccc gaacccgacg ggccgatcag gaagacgaac tcacccttgt cgatcttgac
3471301 gttgatgtca tccaacgccg gacgcgccga cgatttgtac tgcttggtga catggtccag
3471361 ggtgatcatc acggcacgcc agtgtagcgg tgagattagc gggcaggcga aatcaacggg
3471421 tcggtggctc ggatttgggg taggtgccgg ccgtcggacc cggcccgggc tgcggtagcg
3471481 gtgccggtgg tgttggggtc gtggtgcccg ggccgaacgg cggcggcaac tcaaacggcg
3471541 gcgggacagc cgaatcggtc gtggtttcgg gcgggctgac cggcggtgtg ctcgacgtgg
3471601 tggtcggcgt cgccttgacg gtgggtggtt gcactctggt tcgcggcacc caggtgtagt
3471661 caggatcggg cacgaagccc ggcggcacca cctgggtcgg cggagagtca ccaggacctg
3471721 gtgcctgtgg cctataggtc tcgtaaatcc accacaccgc caggaacgcg gcgatcaaca
3471781 ccagggtcga cgtgcggatc cggccgaaca gatagcccgg ccagtgccgt ttctggttgc
3471841 tgagcttcac gctactgctc cggactttct gccaccgcgg cccgcgcatc ggccgcggtg
3471901 actatcccgg cgcgggtgag cgcgcggatc accagcaccc gcaactgccg gcccgcctcg
3471961 aactgcttgc cgggtagggt gcgggccacc agtcgcaggg tgacggtgtc cacttcgatg
3472021 cgctccacgc ccatgaccgt gggctcatcc aacaacagct ctcccagcag cgagtcgtgg
3472081 cgcgcgtgct cacactcctg atgcaagacc tcgttcacgc ggccgagatc ggcgctggtc
3472141 gggacgggga tgtccacgac cgcgcgggcc cagtccttgg acaggttgac cgacttgacg
3472201 atgttcccgt tgggaacggt gaacacctca ccctcgctgg aacgcagctt ggtcacccgc
3472261 agcgtgacgt cctccaccgt gccggccgcg ttctccggtg accccaccat gctgagttcg
3472321 accaaatcgc cgaacccgta ctgcttctcc acgatgatga agaacccggc gagtaggtcc
3472381 tgcaccaggc gttgggcacc gaagcccagc gcggcgccga gcaccgccgc cggccccacc
3472441 aacgcaccga ccggaaccgg caacacatcg atgacctcgt acacaacgac gacatagatg
3472501 aggacgatcg acacccacga gatcaccgac gctacggcct ggcggtgctt ggttgcctcc
3472561 gagcgcacca acgcgtcgct ttcggtaaac cccaggtcga ggcgccgggt cacccggttg
3472621 gcaagccaag tcacgaagcg ggccgccagc accgctgcga tcagcagcat gacgatgcgc
3472681 aggccccggt tgaggatcca gtcgccgatt tcaccgcgcc agaagttatg ccagtgctgt
3472741 gctatcgagg tggccagaac tgtgccgcta gtcgtcatta cgtcgattgc gccaccggat
3472801 cccggcttcc aggaatccgt cgaggtctcc atccagaacg gccgccggat tgccgacctc
3472861 gtactcggtg cgcagatcct tgaccatctg atatgggtgc agcacatagg aacgcatctg
3472921 gttaccccag gagctgccgc cgtcggcctt caacgcgtcg agctcggcgc gttcttctaa
3472981 gcgcttgcgt tccaacaact ttgcttgcag aacccgcatc gccgcgatct tgttctgcag
3473041 ttgggacttc tcgttctggc aggtgaccac gataccgctg ggaatgtggg tgagccgcac
3473101 cgctgagtct gtcgtgttca ccgattgccc gccgggcccg ctggagcgat agacgtcgac
3473161 gcggacatcg ccctcgggga tgtcaatgtg gtcggtggtc tccaccaccg gcagcacttc
3473221 gacttcggcg aacgacgtct gtcgccggct ctggttgtcg aacgggctga tccgcaccag
3473281 ccggtgggtg ccctgttcga ccgacaacgt gccgtaggcg aacggtgcgt gcacggcgaa
3473341 cgtggcgctt ttgatgccgg cttcttcggc ataggaggtg tcgaacacct cgacggggta
3473401 tttgtgctgc tcggcccagc ggatatacat ccgcatcagc atctcggccc agtctgcggc
3473461 gtccacccca cccgcgccgg accggatggt gaccagcgcc tcacgctcgt cgtattcccc
3473521 cgacagcagg gtgcgcacct cggtggcctc gatgtcggcg cgcaacgact tgagctccgc
3473581 gtcggcctcg gcgacggcat cggcggcggc cgcgcccgct tcctcggcgg ccagctcgta
3473641 gagcaccggc aggtcgtcca ggcggcgcct tagctcctcg acgcgccgca gctctccctg
3473701 ggtgtgcgac aactcgctgg tcacccgctg cgcccgggtc tggtcgtccc acaagtgcgg
3473761 atcagatgcc tcatgctcga gcttctcgat gcggctgcgc agaccctcga cgtcgagcac
3473821 ccgctccacc gtggtcaggg tgcagtccaa ggcggcgatg tcggcttgac ggtcggggtc
3473881 cacagcagcc aaggttaccg gcatcagcgt ctagcatcag atgaccgtca tgtgcaccgc
3473941 acgactgcgg cccagcccat tcgcagcccc ttgcgccgca gccgggcaca acacagaggc
3474001 tcgagtatgc gtccctatta catcgccatc gtgggctccg ggccgtcggc gttcttcgcc
3474061 gcggcatcct tgctgaaggc cgccgacacg accgaggacc tcgacatggc cgtcgacatg
3474121 ctggagatgt tgccgactcc ctgggggctg gtgcgctccg gggtcgcgcc ggatcacccc
3474181 aagatcaagt cgatcagcaa gcaattcgaa aagacggccg aggacccccg cttccgcttc
3474241 ttcggcaatg tggtcgtcgg cgaacacgtc cagcccggcg agctctccga gcgctacgac
3474301 gccgtgatct acgccgtcgg cgcgcagtcc gatcgcatgt tgaacatccc cggtgaggac
3474361 ctgccgggca gtatcgccgc cgtcgatttc gtcggctggt acaacgcaca tccacacttc
3474421 gagcaggtat cacccgatct gtcgggcgcc cgggccgtag ttatcggcaa tggaaacgtc
3474481 gcgctagacg tggcacggat tctgctcacc gatcccgacg tgttggcacg caccgatatc
3474541 gccgatcacg ctttggaatc gctacgccca cgcggtatcc aggaggtggt gatcgtcggg
3474601 cgccgaggtc cgctgcaggc cgcgttcacc acgttggagt tgcgcgagct ggccgacctc
3474661 gacggggttg acgtggtgat cgatccggcg gagctggacg gcattaccga cgaggacgcg
3474721 gccgcggtgg gcaaggtctg caagcagaac atcaaggtgc tgcgtggcta tgcggaccgc
3474781 gaaccccgcc cgggacaccg ccgcatggtg ttccggttct tgacctctcc gatcgagatc
3474841 aagggcaagc gcaaagtgga gcggatcgtg ctgggccgca acgagctggt ctccgacggc
3474901 agcgggcgag tggcggccaa ggacaccggc gagcgcgagg agctgccagc tcagctggtc
3474961 gtgcggtcgg tcggctaccg cggggtgccc acgcccgggc tgccgttcga cgaccagagc
3475021 gggaccatcc ccaacgtcgg cggccgaatc aacggcagcc ccaacgaata cgtcgtcggg
3475081 tggatcaagc gcgggccgac cggggtgatc gggaccaaca agaaggacgc ccaagacacc
3475141 gtcgacacct tgatcaagaa tcttggcaac gccaaggagg gcgccgagtg caagagcttt
3475201 ccggaagatc atgccgacca ggtggccgac tggctagcag cacgccagcc gaagctggtc
3475261 acgtcggccc actggcaggt gatcgacgct ttcgagcggg ccgccggcga gccgcacggg
3475321 cgtccccggg tcaagttggc cagcctggcc gagctgttgc ggattgggct cggctgatca
3475381 gcgaccgagc aacacccctg ggttgaggat cccggccggg tcgagtgcgg acttcgccgc
3475441 ccgcagggcc gccgcgaacg ggtcgggacg ctgccggtca taccaagcgc ggtggtcgcg
3475501 accgaccgca tggtggtggg tgatggtacc gccactggcg ctgatcgcct cggacacggc
3475561 agccttgatc tcgtcccact gcgcgtcgag cgacccccag cgcccgccgg catagatgcc
3475621 gtagtaagga gccgggccgt ccgggtagac atgggtgaat cgacaggtca ctactccggt
3475681 cccgcatacc ttccagatcg cggtccgagc ggcatcggtc accgcggcat gtagagtatc
3475741 gaatccgtcc caggtgcaag cggtttcgaa tgtttcggcg ataactccgc ggcgaaccag
3475801 cgcgtctcgt tgatacggca tgcgcagaaa cgccgagcgc cagttcgcgg ctgcgttgtg
3475861 ttccgttgcg tcgcttgtag ttccgcggct acgttgcgcg gtcaccgtgc cgccgtgttc
3475921 ggcggtgatc gccaccgccc ggtgcagcca cgggtctatc gggtggtcgg cagactcgaa
3475981 cgccaacacc aacagcccgc caccaacgga cgtgccggca ttcagcaacg cctcggccgg
3476041 atccaacagc cggcagttgg ccgggtacag ccccgcctga gcgatcgtcc gggtcgcggc
3476101 gaccgcggcg gcccagtcgt caaacaccac ggacaccgtg acctgccatc gcggacggtg
3476161 ttgcagccgc atccacgcct cggtgatgat gccaagcgtc ccctcggacc cgaggaacaa
3476221 ccggtccggg gatggtccgg caccgcttcc gggcagccgc cgggactcgc tgatccccac
3476281 cggggtgaca atccgcagcg attcggtcaa gtcgtcgata tgggtataga gcgtggcgaa
3476341 gtgtccgccg gagcgggtgg ccaaccagcc accgagagtc gagaagccga aggactgcgg
3476401 gaaatggcgc agtgtcaaat cgtgtgggcg aagctgatgc tcgatcgagg ggccgaacgc
3476461 acccgcctgg atgcgcgcgg cacggctgac acggtcaatc tcaagcaccg cgctcatggc
3476521 agtgacgtcg accgtgacca ccggctcatc gaagcgcggc tcgacaccgc caaccaccga
3476581 gctgccacca ccgtatggga tgaccgcaat cccctcgcgc gcacaccaat ccagcacgtc
3476641 gatcacgtcc tgctcgctgc ggggtcgggc gatgaggtcg ggcaggtggt cgagctggcc
3476701 ctgcaggttg cgtgcgatgt cgcgatacgc tttgccgcgc gcgtgtccgg cccgatcgac
3476761 gagatcgctt gagcagagcg cggccagcga tgccggcggg ctgacccgtg gggccgccaa
3476821 accgagcgcg gtcaggtccg gcggcgggtg gtcgctcagg tcatggccgg acaccagtgc
3476881 cgcgactcgc gactgtagcg cttgcgtctc ctgatcggag agcgcgtcct cgactgtgcc
3476941 ccaaccccac cacgaacgca tgctgatggt gtcagcgttt gaggacgatc atggctccgc
3477001 cgacgaccac cagcaccagg gccgcgacga tagcccatcc agcaccggct agccaccaca
3477061 tgacacccaa tgcggcgagt accggcgaca gcgcgaagaa caccattacc gggtgctgcc
3477121 taatcactgc gagggcactg gtcgcccgga ctcgatcgat ttccttgcct ggcatgccct
3477181 tcaggatgcc agctgactac cacaatgcaa gcagcgatga gccgacgaac cgtcatcctt
3477241 ggcctgctcc cgctcgctgt tgtcgtcacg aatggcgcac gatgcggcgc accaatgcct
3477301 gtgaccgaag gcggttcggg ctgtcattga caattcatga agatgcctgc cgcatcatat
3477361 ccgttgtgcc cgttgttcta gaagtccgac gtgctgagcc tgcccacccg gcgaccccat
3477421 atccggaacc cctcgcgcgc tgcagccgct cacctggtct gaacgaaagc tcgcacatga
3477481 gtggtcggat tccgccctaa caacgcgcca taaacgcagg ctcatgcgct gcgccacgat
3477541 gcgccgatgc atttcggtaa cgattgttag ttaacccttg tacgaaactc tcttgaggcg
3477601 ctctaaccga ctgcgtccaa agtggaggat cgaaaagatg ataggaaaat gagtacgcct
3477661 acgctgcctg atatggtagc tccatccccg agagtgcgag taaaagaccg ttgtcgccgg
3477721 atgatggggg acctacgcct ttccgttatc gatcagtgca atttgcgatg ccgttattgt
3477781 atgcccgaag agcactacac atggttgccg cggcaagatt tgctatccgt caaagaaatc
3477841 agcgccattg tagatgtttt cctttccgtt ggggtaagta aagttcgaat caccggtggc
3477901 gaaccgctga tccgcccaga tttgccggaa atagtgagga cattgagcgc aaaggtcggc
3477961 gaagattcag gtctgagaga cttagcgatc acgacgaacg gcgtccttct cgccgaccgc
3478021 gttgacggcc tgaaggctgc gggtatgaaa cgcatcactg tcagtcttga tacgttgcaa
3478081 cccgagcgct tcaaggcgat aagtcagcgt aatagccacg ataaggtcat cgcgggtatc
3478141 aaggctgtcg cagccgcggg atttacggac acaaaaatag acacaacggt gatgcgtggt
3478201 gccaatcacg atgagctggc tgatctgatc gaattcgctc ggactgttaa cgcggaagtc
3478261 aggttcattg agtacatgga cgtcggcggc gcaactcact gggcatggga gaaggtcttt
3478321 accaaagcga acatgctcga gtcccttgag aaacggtatg gacgtattga gcctttgccc
3478381 aaacatgata cggcgcccgc caatcgatat gcgcttccgg acggaactac cttcggaatt
3478441 atcgcgtcga caacggagcc attctgcgca acctgtgacc gttcacggtt gaccgccgat
3478501 ggcttatggc tgcattgctt gtacgcaata tcgggtatca acctaaggga gccgctgcgt
3478561 gcaggcgcga ctcacgatga cttggtggaa accgtgacaa ccggatggcg gcgacgaacg
3478621 gatcgcggag cagagcagcg tcttgcccaa cgcgagcgcg gagtgttcct gccattaagc
3478681 acgttaaagg ccgacccgca tctggagatg cacaccaggg gcgggtaagc cgaacgaaca
3478741 gtcgattgat caacgactcc acagttgagg aaggaaccat gacggtcagc acccctgagc
3478801 aacacgagca acgagcatcc cacgatgcat ccgagggaaa gcacaacgta tgtcagggga
3478861 ggctggccgc acttgccgac gcggccgtgt cagagaaact cggagcacta cctggctggc
3478921 agcttctcga catgcgactc agccgcgctt ttcagtgcac aaatttcgac caatccattg
3478981 acttcatgaa tagggtcgca tcaatagcaa acgatatcaa tcaccatccc gatatcgctg
3479041 tactggacaa gcgttcggtg cgcgtgacgg cgtggacgcg caagctgggc tatctgaccg
3479101 acatcgactt cgatcttgcg gcgtccgtcg aggcgatgta tgcgacagaa ttcgctgaca
3479161 ggccagcacg atgatcgacc atgcactcgc gctgacacat atcgatgagc gtggtgcggc
3479221 acgaatggtc gatgtgtccg agaaacccgt gactttgagg gttgccaaag cgtcagggct
3479281 cgtgatcatg aagccgtcta ccttgaggat gatttccgac ggtgccgctg ctaagggtga
3479341 cgtcatggcg gcggcccgga tagctggcat cgcggcggcg aaacgtacgg gtgatcttat
3479401 tccgctatgc cacccgttag ggctcgacgc tgtcagcgtc actatcacgc cgtgcgagcc
3479461 tgaccgggtg aagattctgg cgacaaccac cacgctgggg cgtaccggcg tggaaatgga
3479521 agcgttgacc gcagtttcag tcgccgcctt gactatctac gacatgtgca aagccgtcga
3479581 tcgagccatg gagatttctc agatcgtgct ccaagagaaa agcggcggcc ggtccggagt
3479641 ttatcgccga agtgcttctg atttggcctg tcagtcccga taagtaggtg agtgtctgaa
3479701 tgattaaagt gaatgttctt tacttcggtg ccgttcgtga ggcgtgtgac gaaacgcctc
3479761 gggaggaagt agaggttcag aacggtaccg atgtcgggaa tcttgttgat caactccagc
3479821 aaaaataccc tcgccttcgc gatcattgtc agcgagtaca gatggcggtc aaccaattca
3479881 tcgcgccgct gtcgaccgtt ctcggcgatg gtgatgaggt cgccttcatc ccgcaggtag
3479941 ccggaggctg aacaagggga tgaccggccg tgaatgcgct ctcatcgtcg ccgctgttcg
3480001 gcaacgtggg agttccagtg ccggcgtgca gaacgaccga aattcgccgc acccgaatag
3480061 tcgggtcgca tagatgacca gcagggatgg attcaccatc gtttgggatt ggaacgggac
3480121 gctgtgcgac gaccggacaa ttcttctcga cgcggttggg cagacgctgg tcaacgaggg
3480181 attcgagcct ctttcgcaac agcagctgat ccaacggttc gcacgcccac tacgaacgtt
3480241 tttcgagaat gcgtgcggtc gagatctctt gacgtccgag tgggaacgcg tccaatccac
3480301 ctttcgccga atctatcgat cgcgagaagc tgaagtcaca ctcgtcgaag atgcgtacga
3480361 cgttctggcg cagggaaacc gcagcgccgc tgggcagttc ttattatcgc tggcgcctca
3480421 cgacgagctt atgcacttcg tccaaaaata cgggattgcc aagtggttca acggaatccg
3480481 tggccggact cggcccgacc aagaaaaacc catgatgctg gcagaactga tcatgcagcg
3480541 ctctctgaat cccactcgcg tggtgcacat cggcgattcg cttgaggacg ccgctgctgc
3480601 cagcgcggtc ggagccattt ccgtcttggt caccggagct tcactgcagc cacccgaccg
3480661 agtcatgctc aaacagttgc agcccttcgt tgcgagttcg ctgaagcaag cactgcagta
3480721 cgcgggtggc gacggtgatt gacgacgaag gtacgcaggt ggtggcggcg cgcctgccgt
3480781 tcggatggtc agccgacagt ggggtgacag ccgacatcat cgaggcagcg atggaacttg
3480841 cgatcgacac agcgcgacat gccacggcac cgtttggcgc tgcgctgctt gatgttacga
3480901 cactccgagc attctcgggt ggcaacacct attttgaatc gggggatcgc ttcgctcacg
3480961 ccgaaaccaa cgttctacgg gccgcaatga gcacattgcc ggagctttca aatcacgtgc
3481021 tgatatccac cgccgagcca tgcccgatgt gcgcggcggc cagcgtgctc agcggagtga
3481081 gagccatcat cttcggcaca tcaatcgaga cccttatcca gtgcggttgg ttccaaatcc
3481141 gcatcagcgc ttcggatgtg gtggcggcct ccactcgtcc cacgcgtcca tcggtgtata
3481201 gcggtttcct cagccacaag acggacttgt tgtaccggaa ctccgaaaac cgacgagcaa
3481261 tgaacccctg gaccgatcca tcgcattgac tcggcttgcc gactacctca ctgacccagg
3481321 aggagagtta cgtccagggg tgtggtgtac gggcaggtaa ggccggtggg cgtgtcgtag
3481381 cccagtagtg ggcggtcatc gcgtgatcct tcgaaacgac cagcaaaagt caatcgaagg
3481441 aaatgacgca atgacctctt ctcatcttat cgacgccgag cagcttctgg ctgaccaact
3481501 cgcacaggcg agcccggatc tgctgcgcgg gctgctctcg acgttcatcg ccgccttgat
3481561 gggggctgaa gccgacgccc tgtgcggggc gggctaccgc gaacgcagcg atgagcggtc
3481621 caatcagcgc aacggctacc gccaccgtga tttcgacacc cgtgccgcaa ccatcgacgt
3481681 cgcgatcccc aagctgcgcc agggcagcta tttcccggac tggctgctgc agcgccgcaa
3481741 gcgagctgaa cgcgcactga ccagcgtggt ggcgacctgc tacctgctgg gagtatccac
3481801 tcgccggatg gagcgcctgg tcgaaacact tggtgtgaca aagctttcca agtcgcaagt
3481861 gtcgatcatg gccaaagagc tcgacgaagc cgtagaggcg tttcggaccc gcccgctcga
3481921 tgccggcccg tataccttcc tcgccgccga cgccctggtg ctcaaggtgc gcgaggcagg
3481981 ccgcgtcgtc ggggtgcaca ccttgatcgc caccggcgtc aacgccgagg gctaccgaga
3482041 gatcctgggc atccaggtca cctccgccga ggacggggcc ggctggctgg cgttcttccg
3482101 cgacctggtc gcccgcggcc tgtccggggt cgcgctggtc accagcgacg cccacgccgg
3482161 cctggtggcc gcgatcggcg ccaccctgcc cgcagcggcc tggcagcgct gcagaaccca
3482221 ctacgcagcc aatctgatgg cagccacccc gaagccctcc tggccgtggg tgcgcaccct
3482281 gctgcactcc atctacgacc agcccgacgc cgaatcagtt gttgcccaat atgatcgggt
3482341 actcgacgct ctgaccgaca aactccccgc ggtggccgag cacctcgaca ccgcccgcac
3482401 cgacctgctg gcgttcaccg ccttccccaa gcagatctgg cgccaaatct ggtccaacaa
3482461 cccccaggaa cgcctcaacc gagaggtacg acgccgaacc gacgtcgtgg gcatcttccc
3482521 cgaccgcgcc tcgatcatcc gcctcgtcgg agccgtcctc gccgaacaac acgacgaatg
3482581 gatcgaagga cggcgctacc tgggcctcga ggtcctcacc cgagcccgag cagcactgac
3482641 cagcaccgaa gaacccgcca agcagcaaac caccaacacc ccagcactga ccacctagac
3482701 tgccacccga aggatcacgc gaggaacctt cactcgtaca ccacgtccct ggccttggcc
3482761 aggaggagag caatcatgac tgaagccttg atcccggcac cgtcgcagat atcgctgacc
3482821 cgcgatgagg tgcgcaggta cagcaggcac ctcatcatcc cggatatcgg cgtcaacggc
3482881 caacagcggc tgaaggatgc gcgcgtattg tgtatcggcg ccggaggatt gggttcgcct
3482941 gctctcctgt atcttgcggc cgccggagtc ggtaccatcg gcatcatcga tggagaccac
3483001 gtggatgagt cgaatctgca acgccaaatc attcatggca catccgacgt gggtaggccg
3483061 aaagtagaat cagcagccga ggcggtggcg gaaatcaacc cgcacgtccg ggtgacgcaa
3483121 tatcgcgaaa tgctcaccca cgacaacgca ctggaaattt ttggcgatca cgacctcatt
3483181 gttgacggca cagacaactt cacgacgcgc tacctgatca atgatgccgc ggtcttggcc
3483241 ggcaaaccat atgtttgggg gtcgatctac cgattcaacg gccagaccag tgtgttttgg
3483301 cccggccggg ggccgtgtta tcgatgcctt catccagctc cgcccccgcc cggattggtg
3483361 ccgtcgtgcg ctgaaggcgg tgtactcggt gccatctgcg ccacgattgc gtcgatccag
3483421 gtaactgaag tgctgaagct ccttaccgga gtcggaactc ccctcgtcgg tcgcctgctc
3483481 atgtatgaag ctctcgacgc gacataccat caaatccgga tcgcgaagaa tcctgactgc
3483541 gccatttgcg gcgatgcgcc cacgatcacc gaattggtag atgacagcgt cagctgcgca
3483601 tcgacacaat cggtggatcc cgaactagtg atcagttgtg atgagttgcg aaccaaacag
3483661 cagtcggacc agaacttcct cttggtcgac gtgcgagagc ccgccgagtt cgacatcgcg
3483721 cacattccgg gcagcatctt gatacccaaa ggcgaaatcg gctcggcggc gggcctagcc
3483781 cagctaccgc tggacaagga aattgtcctg tactgcaaga gtggaatccg atcggcccag
3483841 gcgctaacca cgttgaaagc agccggactg cacaacgtga agcatctcga cggcggtatc
3483901 gcggagtgga cacgaaccat cgactcctcc ttgttggtgt actagcaccg aactatgcga
3483961 aaggattccc gccatggcac gctgcgatgt cctggtctcc gccgactggg ctgagagcaa
3484021 tctgcacgcg ccgaaggtcg ttttcgtcga agtggacgag gacaccagtg catatgaccg
3484081 tgaccatatt gccggcgcga tcaagttgga ctggcgcacc gacctgcagg atccggtcaa
3484141 acgtgacttc gtcgacgccc agcaattctc caagctgctg tccgagcgtg gcatcgccaa
3484201 cgaggacacg gtgatcctgt acggcggcaa caacaattgg ttcgccgcct acgcgtactg
3484261 gtatttcaag ctctacggcc atgagaaggt caagttgctc gacggcggcc gcaagaagtg
3484321 ggagctcgac ggacgcccgc tgtccagcga cccggtcagc cggccggtga cctcctacac
3484381 cgcctccccg ccggataaca cgattcgggc attccgcgac gaggtcctgg cggccatcaa
3484441 cgtcaagaac ctcatcgacg tgcgctctcc cgacgagttc tccggcaaga tcctggcccc
3484501 cgcgcacctg ccgcaggaac aaagccagcg gcccggacac attcctggtg ccatcaacgt
3484561 gccgtggagc agggccgcca acgaggacgg caccttcaag tccgatgagg agttggccaa
3484621 gctttacgcc gacgccggcc tagacaacag caaggaaacg attgcctact gccgaatcgg
3484681 ggaacggtcc tcgcacacct ggttcgtgtt gcgggaatta ctcggacacc aaaacgtcaa
3484741 gaactacgac ggcagttgga cagaatacgg ctccctggtg ggcgccccga tcgagttggg
3484801 aagctgatat gtgctctgga cccaagcaag gactgacatt gccggccagc gtcgacctgg
3484861 aaaaagaaac ggtgatcacc ggccgcgtag tggacggtga cggccaggcc gtgggcggcg
3484921 cgttcgtgcg gctgctggac tcctccgacg agttcaccgc ggaggtcgtc gcgtcggcca
3484981 ccggcgattt ccggttcttc gccgcgcccg gatcctggac gctgcgcgcg ctgtcggcgg
3485041 ccggcaacgg cgacgcggtg gtgcagccct cgggcgcggg catccacgag gtagacgtca
3485101 agatcacctg atagctagga aggatgtctg aatggccaat gtggtagctg aaggtgccta
3485161 cccttactgt cggctcactg atcagccgct gagtgtggac gaagtgctag ccgccgtctc
3485221 gggccccgaa caaggcggca ttgtcatatt tgtgggaaac gtgcgtgacc acaatgccgg
3485281 gcatgatgtc acgcggttgt tctacgaggc gtatccgccg atggtgattc ggacattgat
3485341 gtcgatcatc ggacggtgtg aagacaaggc cgagggtgtc cgcgttgctg tcgcgcaccg
3485401 gaccggtgaa ttgcaaatcg gtgatgccgc ggtcgttatt ggcgcgtcag ctccccaccg
3485461 tgcggaggca tttgacgccg cgcgtatgtg tatcgagttg cttaagcagg aagtgccgat
3485521 ttggaagaag gaattcagct cgaccggtgc tgaatgggtc ggcgatagac catgagtccg
3485581 tctccatcgg ccctgctcgc cgaccacccg gaccgcattc gttggaacgc gaaatacgag
3485641 tgcgctgacc ccacggaggc ggtatttgcg cccatatcct ggctcggcga cgtgctgcag
3485701 ttcggggtgc cagaagggcc ggttctggaa ctggcgtgcg gtcggtccgg caccgcgctg
3485761 gggctagccg cggcgggccg ctgcgtgact gcgatcgacg tttccgatac cgcgttggtt
3485821 cagctcgagc tcgaagcgac ccgacgggaa ttggccgatc gcctcacact ggtgcacgcc
3485881 gatctctgct cctggcagtc gggggatgga cgctttgctc tggtactttg ccgactattc
3485941 tggcatccgc ccacttttcg ccaggcttgc gaggctgtgg cgccgggcgg tgtagtggcg
3486001 tgggaggcat ggcggcggcc catcgatgtc gctcgggata cccgtcgagc cgaatggtgc
3486061 ttgaagccag gccagcccga gtctgaactt cccgccggct tcacggtgat tcgggtggtc
3486121 gacaccgatg gttcagagcc gtcgcggcgc atcatcgccc aacggtcact gtgaacggtc
3486181 cctggttgta tgcgcacgtc ctttgttgag aacccgtttc gcaccgctcc gataccgcca
3486241 gtctgatgca ccgaccgcgc cgcctcccac ccgcggaagc taacgaggtg tgcatgaaac
3486301 cggggcggtt cagcagcccg gttaattgac aatctgtgaa gaggttccca cgacaatggg
3486361 cacgttgggc tcgcgatgtc gcgcgattcg agcgaggttg ggtgacgttc ccgtttgagg
3486421 atctcgcccc agggcgatgg gttggcggga tgtcgatgta cccggaagag caaaacgtgg
3486481 catgcgataa cgatccgaga ggagtgcgat gacaagcacc tcgattccga cgttcccgtt
3486541 cgaccggccg gtcccgacgg agccgtcccc aatgctgtcg gaactgagaa acagctgtcc
3486601 ggtagccccg atagagttgc cctcggggca cacagcatgg ctcgtcactc gctttgacga
3486661 tgtaaaggga gtgctgtccg acaagcgttt cagctgcagg gcggcagcgc acccgtcgtc
3486721 gcccccgttc gtgccgttcg tgcagctttg ccccagcttg ttgagcatcg atgggcccca
3486781 acacaccgcg gcccgccgtc tgctcgcgca gggcctaaat cccggcttca tcgcacgcat
3486841 gcggcccgtt gtccaacaga tcgtcgacaa tgcgctcgac gatctggcag ccgcggaacc
3486901 accggtggac ttccaggaaa tagtaagtgt ccctatcgga gaacagctca tggccaagct
3486961 actcggggtc gagcccaaaa ccgtgcacga gctcgcggcg cacgtggatg cggcgatgtc
3487021 cgtgtgtgag atcggcgacg aggaggtgag ccggcggtgg tcagcactgt gcacgatggt
3487081 catcgacata ctgcaccgca agctcgccga accgggtgat gacctactta gcacgatcgc
3487141 ccaggcgaac cggcaacagt ccaccatgac cgacgagcag gttgtcggca tgctcctcac
3487201 cgtcgtgatc ggaggagtcg acacaccgat cgccgtgatc acaaacgggc tggcgagcct
3487261 gctgcaccac cgcgatcaat atgaacggct cgttgaagac ccaggccgtg tcgctcgtgc
3487321 ggttgaagaa atagtccggt ttaatccggc aactgaaatt gagcacttgc gagttgtcac
3487381 cgaggatgtc gtcattgccg gaaccgcgct atcggcgggg agcccagcat ttacctctat
3487441 cacttcggct aaccgcgact ccgaccaatt cctggacccc gatgagtttg atgtcgaacg
3487501 taatccgaac gaacacatag catttggata tggtccacat gcttgcccgg cctcagcgta
3487561 ttcacgcatg tgcttgacga cgttcttcac ctcgcttacc cagcgatttc cgcaacttca
3487621 actcgcaaga ccgtttgagg atttggaacg acggggtaag ggcctacatt cggtggggat
3487681 caaggaactc cttgttacct ggccgacgtg accccgcgtg ccagcaaggg actgttgact
3487741 tctccgacgg atgaaagccg ccctggaata tccaaccgct cctgctcctc ggtcaactca
3487801 agccgaaacc gccaacggtg gccacaaaat acgagttcgt ccacaacgtc ggcagccggg
3487861 accgcaacca cgcaaactcc tcacgcacta cccgcaaccg acggccccta attggggttg
3487921 ggcccatgat cggttggcgg ctcatcaggc ggtgcaggat cttggtgtgc ccgcctcggc
3487981 gcggcggagc cggggtcgag catctctttg cgagtgatga aggcacagcc ccggcgcggg
3488041 gtgggtgtgc aacacgaatg taggtagcgg gagttgaggc tgggcgcggt gtattctggt
3488101 tgttggataa acaaccagaa tggggagacg cgggtgggcg aggactcgct ggaggatctg
3488161 gagcagcggc gagcgcgact gtatgaccag ttggccgcga ccggcgattt ccggcgcggc
3488221 tcgatcagtg agaactatcg ccgctgcggc aagcccaatt gtgtgtgcgc gcaagagggt
3488281 caccccgggc atgggccgcg atatttgtgg acgcgcacgg tggccgggcg gggtaccaag
3488341 gggcggcagc tctcggtcga ggaggtggac aaggtgcgcg ccgagttggc caactatcac
3488401 cgtttcgcgc aggtcagtga gcagatcgtg gcggtcaacg aggcgatctg cgaggcccgc
3488461 ccaccgaacc cggcggccac ggcgcccccg gccggcacaa cggggcacaa aaaagggggc
3488521 tctgcgacca gatcgcggcg gagttcaccg ccgaggtaga gcggctggtt gcgctcgcgg
3488581 tcggtgcgct gggatcctcg gtgccgacct ggtcgcagtg gagttggcga tccgcactgc
3488641 gatgacccgg ctgggctcct cgctgctgga gcagctgctg ggcgccgaca ccgggcaccg
3488701 gggccagcgc atcgattgcg ggcaagggca ttgcgcgtgg ttcgtcggtt accgcgacaa
3488761 gaacctcgat accgtgctgg accgggtccg gttgctccgc gcctgctacc actgccgcac
3488821 ctgcgggcgt gggatggcgc cccctggatc tggaacctgg ccaccgcgat cctgcccgaa
3488881 gccaccccga tcgtggacct ctaccacgct cgccagcacg tccacgacct cgccggccag
3488941 ctcgcacccg ccctcggcga acaccacagt gactggctga ccgcccggct ggtcgacctc
3489001 gactccggcg acatcgaaac gctggttcaa caaccgatcg ggcagcacac cggtcacacg
3489061 taacgaagtg tgcatgaaac ccggagtggt tcaggggtcc gccgcgctcg tccgcgctgt
3489121 gagggtctcg gcactaccac gagatgagat cgaggcacca ggtgcattgt gcaccacatt
3489181 ctggcgatgt tggtgaggtt tgttcctgcg cccgtccgtg gcgcgttcgg gatcgttggg
3489241 gttggccggt tgcccacctc ggcggaagcg gacggtgagc gcggccgagt cgtcgacatt
3489301 tggcggtagg aggtttcgat gctgtttgtc agcgtggccc cggagtcggt aggggtggcg
3489361 gcggcgactc ttgttgggcc cccgttgatc ggcaacggcg ccgatcggcc cccggcaccg
3489421 gacaagccgg cgggatcttg tggggcaacg gccgttttcg cccaatcaca ggagtggagt
3489481 tttgaacgca acgacggcag gtgctgtgca attcaacgtc ttaggaccac tggaactaaa
3489541 cctccggggc accaaactgc cattgggaac gccgaaacaa cgtgccgtgc tcgccatgct
3489601 gttgctatcc cggaaccaag tcgtagcggc cgacgcactg gtccaggcaa tctgggagaa
3489661 gtcgccacct gcacgagccc gacgcaccgt ccacacgtac atttgcaacc ttcgccggac
3489721 cctgagcgat gcaggcgttg attcgcgcaa catcttggtt agtgagccgc cgggctatcg
3489781 ccttctcatt ggagatcgac agcaatgcga tctcgaccgt ttcgtggcag cgaaagaatc
3489841 gggactgcgc gcttctgcca aaggatattt tagcgaggcg atccgttatc tagattcggc
3489901 cttgcagaat tggcgcggtc cagtactggg ggacctacgc agctttatgt ttgtccaaat
3489961 gttcagcagg gcgttgaccg aagatgagct cctcgtccat acgaagctgg ccgaagctgc
3490021 aatcgcctgc ggacgcgccg acgtcgttat ccctaaattg gaaagactcg ttgcgatgca
3490081 tccttatcgc gagtcgttat ggaagcagtt aatgctcggc tactacgtga acgaatacca
3490141 gtccgcggca atcgacgcat atcatagact caagtccacg ctcgcagagg aactcggtgt
3490201 tgagccggca cccacgatac gtgcgctcta ccacaaaatt cttcgccaat tgcccatgga
3490261 cgatctcgtc ggccgagtca cgcgtggcag ggttgacttg cgtggcggca acggcgctaa
3490321 ggtagaggaa ctgaccgaga gcgataagga tctccttccc atcggtttgg cataactacg
3490381 cccctcaatg caagcgagct gattcgatgt tgtcgagccg gagcccgctc cgacctccgt
3490441 cacacagacc ggactacgaa tactgacccg cgctgctagc caaccccggt tcgtggaatc
3490501 acagtgagac gtgcctgcgt gacatgccaa cccgcaccat cacgatccat cagcccaccg
3490561 ggcataccag cgccggcacc gctaatactc attggcatca gcatcatcgg cataccacca
3490621 ccggcggccc cggccgcctg cgtcagcgcg actgggttag gcggcacacc caacccggac
3490681 atcgctgaag aagccatcga aatgggtatc gacccctgcc acgtcggcgg caccgacatc
3490741 gaccccacca actgagcctg ccctaagcca gcggacatcc ccgcacccaa ttcccgaccg
3490801 cctagcggct tgaacgccgg aatagccgca ccactcgggt tcggcgtatt cgcggcagcc
3490861 aacccgccag ccggcggacc taacctggtc gcgctttcac gcgccatact cgccaacgtc
3490921 gttatcggcg acgtcaggat gcggaccggg agaaacaaca tcgacgcatg ttgcaacggc
3490981 agctgcgaca ccagcgactg catcccgctc atcacggtcg gcaccgacgc catcgcaccc
3491041 tcgaccaccg gcgtcacggc agccgacgcc gtcgtcgcca tcccggcaac ctgggtaccc
3491101 acctgcgcgg ccaacccggc taagctcacc ggcggcagac taaatggcgc caacgtcgcc
3491161 gccacggact ttgccccagc gtgatagccc accatcgcag ccacatcctg agcccacatc
3491221 tccaggtaat cgaactccgt ggctgcgatc gccggggtgt tctgacccaa aacgttcgcc
3491281 gctatcaacg acgccagcga cacccgattc gccgtcaccg ccgtcggatg caccgtggcc
3491341 gccaacgcgg cctcaaacgc cgtcgctgcc gcgcgagcct gaatggccgc cagctgcgcc
3491401 tgcgacgcca ccgtgctcaa ccacccgaca tacggagacg cggcagcagc catcgacatc
3491461 gacgccggac cggtccacgg cccagtcgtc aacgcggcga gcaccgactc aaacgacgat
3491521 gccgatgccc acaaatccgc ggctagcccc tcccacgccg aggccgccgc aaacaacggc
3491581 cccgagccgg ctccggcaaa catgcgcgcc gagttgatct ccggcggcag ccacgaaaag
3491641 cccaaaacca tcgcaacccc agcccaatca gccgcccaga agggtctcgt acaagggtta
3491701 actaaacaat cgttaccgaa tgaatcgaca catcgtgacg caccgatggc tcagcacgcc
3491761 ggacttctag aacaacgagc acaacggata tgatgcggca ggcatcttca tggattgtca
3491821 atgacagccc aaaccgcctt cggccactgg cattggtgca ctgcaccgtg cgccattcgt
3491881 ggcgacaact gcgagcggga gcgggaccaa ggatgatggt cccggtcgcg acgggcgcga
3491941 tcccgctccg gagtggtcaa cgcatcaaac gacaaagcgc tcagctcatc gaccgcagca
3492001 tcgagccggt ccagcgccgc gaccaaacta gaattctcgc gcagacaccg ctgaaacgac
3492061 agtgacgcaa gggatttcat tgagaggacc aatgacccta tttgatcaaa ccggatgacc
3492121 ataccgtcaa cgttgtggac atacaggtgc tcaagaacgc agtcttgctg gcatgccggg
3492181 cgccgtcggt gcacaacagc cagccctggc gttgggtggc cgaaagcggc tccgagcaca
3492241 ctactgtgca cctgttcgtc aaccgccacc gaacggtgcc ggccaccgac cattccggcc
3492301 ggcaagcgat catcagttgc ggtgccgtac tcgatcacct tcgcatcgcc atgacggccg
3492361 cgcactggca ggcgaatatc actcgctttc cccagccgaa ccaacctgac cagttggcca
3492421 ccgtcgaatt cagtcccatc gatcacgtca cggcgggaca gcgaaaccgc gcccaggcga
3492481 ttctgcagcg ccgaaccgat cggcttccgt ttgacagccc gatgtactgg cacctgtttg
3492541 agcccgcgct gcgcgacgcc gtcgacaaag acgttgcgat gcttgatgtg gtatccgacg
3492601 accagcgaac acgactggtg gtagcgtcac aactcagcga agtcctgcgg cgggacgatc
3492661 cgtactatca cgccgaactc gaatggtgga cttcaccgtt cgtgctggcc catggtgtgc
3492721 cgccggatac gctggcatca gacgccgaac gcttgcgggt tgacctgggc cgtgacttcc
3492781 cggtccggag ctaccagaat cgccgtgccg agctagctga tgaccgatcg aaagtccttg
3492841 tgctgtcgac ccctagcgac acgcgagccg acgcactgag gtgtggcgaa gtgctgtcga
3492901 ccatcctact cgagtgcacc atggccggca tggctacctg cacgttgacc catctgatcg
3492961 aatccagtga cagtcgtgac atcgtgcggg gcctgacgag gcagcgaggc gagccgcaag
3493021 ccttgatccg ggtagggata gccccgccgt tggcagcagt tcccgccccc acaccacggc
3493081 ggccgctgga cagcgtcttg cagattcgcc agacgcccga gaaagggcgt aatgcctcag
3493141 atagaaatgc ccgtgaaacg ggttggttca gcccgccttg atcaggatgc ctttgtggat
3493201 gtcgggtagg gcggtgggga tgttagcgag gtagagctgc tcggttttct ccttggccaa
3493261 gatgaggagt cggttctgca ggtcggcgat tttgcggccg atctgggcgg ggttgaggct
3493321 gtctcggtag gtgatcaggt cggcctgctg ggccgcggag agcacccttg cggccagtgg
3493381 ccggtccagc ggcgtctgtg gggcatcgta gaggcgtcgg cggcggccgt cggcgctgct
3493441 ggcatacccg atcggtttga tggtcggggt gaggtagttg aggcggtcgt tgaccagctt
3493501 ccacatccgg ttgagcacgg cgcgttcctc ggcggtgtca tagcggtagt agaacgcgta
3493561 cttgcggacc aggtggttgt tcttggactc gatggtggcc tagtggtttt tcttgtacgg
3493621 gcgaaagcgg gtgaagtaga taccgttgtc gccggcccag ctgatgaccg gcttgttgag
3493681 aaacacggtg ccgttgtcga aatctaaacc cgttatccca tgcgggatct cggtgacaga
3493741 agctttgagc ccggcgagga tgtgggtacg ggcgttgttg cggacggtgc gggtgaacac
3493801 ccatccgatg tgcacgtcgg tcaagttcag ggtgtgggcg aactcgcctt tgagcgtcgg
3493861 accgcaatgg gcgacggtgt cgccctcgaa gaaccccggc tccgcctcga cctcatcgcc
3493921 ggccctgcga accttgatcg aattacgcag cagtggtgag ggtttcgtcg tcgacacacc
3493981 cgatatctgg tctttggcct tcgcggtctt cagataacga tcgatgctgg ccgcactcat
3494041 cgccaacagc tcctcacgca cctcggggcc atagcggtca cgcccaaact ccaacacacc
3494101 gtgacgttcc aacccatcaa gctgcagcac catcgaggcg gcaagatact tcccgcactg
3494161 cccacccgag gcggaccaca ccctctgcaa caccttcagc gcgtcatagg agtacttcag
3494221 cgaacgcggt ttgcgccgcc gcttggcaac actgcggccc agccccggcg atagcttggc
3494281 cgctgcgaca agccggcgcc gcgcgttatc acgtgactag cccgtcaggt caaccacctg
3494341 gtcgaaaatc cggccccggc tcttcttcaa agcctgcaca tacgccttgg cgtacctgct
3494401 ggtgacctcc gcgcgagatc tcatcgacaa cccacttccc atgcctcacg acggtcacca
3494461 tgtcgcgggc atatttacgt gaggcaccga gggtgtttcg cgggcattct tggtgagtca
3494521 agtcgaacgg ttgagccatg atcgacgatt ccgttaccgt gctgtcagaa gacgaaagtt
3494581 ggcaccggct gggcagcgtt gcactcggtc ggctagttac cacctttgct gatgagcctg
3494641 ggatcttcca gtcaatttcg tggtgcaagg ccgcaccgtg ctgtttcgta ccgcggaggg
3494701 cgccaaatta ttttcagccg tcgcgaagtg cgcggtggct ttcgaggcgg acgaccacaa
3494761 cgttgccgag ggctggagcg tgatcgtcaa ggttcgcgcc caggtgctga cgaccgacgc
3494821 gggggtccgc gaagccgaac gcgcccagtt actaccgtgg accgcgacgc tgaaacgtca
3494881 ctgtgtgcgg gtgatcccgt gggagatcac cggccgccac ttcaggttcg gtccggaacc
3494941 ggaccgcagc cagacctttg cctgcgaggc ctcgtcacac aaccagcgat agcgctccgc
3495001 gcctgcgagt caccttgcgc cgcttactga tcgccaccag ccgtgcgacg gcgtcttcaa
3495061 ttcctcgcgc cagctggccg gcatctgcta ccacgtcgta gtcggccagg atcccgaagt
3495121 acaggtcgtc ggcgtagctg agcatcgcga cactggtgcg cagttgcatc gcgatcggcg
3495181 aaaccgggta taggtcaagc acccgtctgc ccataatctg cagcggccgt cgtggacccg
3495241 gcacatttgt cgccacggtg acaacaccac gctgcggcag ccgcatcaac agcccgaccg
3495301 cccatgcggt catggggaac ggaaggcggt tggcaatcgc catcaaagta tttccgaatt
3495361 gtctctgtcc ccccgccttg gcccgagtca gccgcgagtg cacgatccgc agccgctgca
3495421 gcgggttctc ttgatccacc ggcaggttgg gcagcattaa cgaaacacgg ttatcggtct
3495481 tgctcaaagc gctgttggaa cgcgtcgaga ccggcactag cgtacgcagc gaatcaaacc
3495541 taggccgctc accccgctgg atgaggacgt tgcggtagct ttccgtaatc gcggcaagcg
3495601 caacatcatt gatggtgacg tcgaatttcc ggcacacctg ttcgacgtcg gcgagaggga
3495661 cctttgctgc gctgtagcga cgcaaatcac tgatcggccc gttcaacgac gacgcggcgg
3495721 gacttagcac gccggccgcg atctcactgg cacccttggc cgcgcgaacg atgcctgcca
3495781 tcacggcggt cgacgcggtc aacgcctcgc ttggattgac acggaatcca ccccgccgca
3495841 cagatgcgga ttgcgactgc atggtcgtgt ggatgttgct cgcgaagctg tcgctcatac
3495901 tttcatcgga gagcccagct agcaggtgag tcgccgcgat tccgtcggcc atgcagtggt
3495961 gcagtttggt caggatcgcc cacttgctgt ccgccaggcc ttcgatgacc cagacctccc
3496021 acagcggtcg accccggtcc aaacgacgcg ccatcagatc ggcgatcagc tcgaataact
3496081 ggtcttcgtt gccaggccgc ggcaaggcga tgcgccacac atgacggcca agatcgaagt
3496141 cgggatcgtc cacccatttg ggtgcaccga ggtcgaacgg gcgcaggcgt aaccgctgcc
3496201 cgaaccgggt acagggacgt aggcgttgag cgagcgacga taagaaggct tcctgatcgg
3496261 gagccggccc ctcgatgacc gccagagcgc cgattgccag actcacgtgc cgatccacgt
3496321 cttctgcctt gagaaacccg gcgtcaagtg tcgttaggtg attcatggtc agcgccttcc
3496381 ccggtgatcc ggattatctg caaccgtcag taccactctc cgctgcgagg agccgttgag
3496441 gcagggccaa aggtcctccg ctggcgagcc ttcgtgctct gccaccgcgg ctgtcgacgc
3496501 gcgatcctta atagatgacc gcagccgttg atgggaaagg cccggcagcc atgaacaccc
3496561 atttcccgga cgccgaaacc gtgcgaacgg ttctcaccct ggccgtccgg gccccctcca
3496621 tccacaacac gcagccgtgg cggtggcggg tatgcccgac gagtctggag ctgttctcta
3496681 gacccgatat gcagctgcgt agcaccgatc cggacgggcg tgagttgatc ctcagctgtg
3496741 gtgtggcatt gcaccactgc gtcgtcgctt tggcgtcgct gggctggcag gccaaggtaa
3496801 accgtttccc cgatcccaag gaccgctgcc atctggccac catcggggta caaccgcttg
3496861 ttcccgatca ggccgatgtc gccttggcgg cggccatacc gcggcgacgc accgatcggc
3496921 gcgcctacag ttgctggccg gtgccaggag gtgacatcgc gttgatggcc gcaagagcag
3496981 cccgtggcgg ggtcatgctg cggcaggtca gtgccctaga ccgaatgaaa gccattgtgg
3497041 cgcaggctgt cttggaccac gtgaccgacg aggaatatct gcgcgagctc accatttgga
3497101 gtgggcgcta cggttcagtg gccggggttc ccgcccgcaa cgagccgcca tcagacccca
3497161 gtgccccgat ccccggtcgc ctgttcgccg ggcccggtct gtctcagccg tccgacgtct
3497221 tacccgctga cgacggcgcc gcgatcctgg cactaggcac cgagacagac gaccggttgg
3497281 cccggctgcg cgccggcgag gccgccagca tcgtcttgtt gaccgcgacg gcaatggggc
3497341 tggcgtgctg cccgatcacc gaaccgctgg agatcgccaa gacccgcgac gcggtccgtg
3497401 ccgaggtgtt cggcgccggc ggctaccccc agatgctgct gcgagtgggt tgggcaccga
3497461 tcaatgccga cccgttgcca ccgacgccac ggcgcgaact gtcccaggtc gttgagtggc
3497521 cggaagagct actgcgacaa cggtgctgac catcgcagca ctgttccgct cgcgcccggt
3497581 acgctcgcga gggtgaattc gccgccggcc tgctctgccc gctgccgcag gttcgttaag
3497641 ccgcttccgg tgaactcgtc gggcagcccg cggccgttgt cggtcacctc gatgcacaag
3497701 tcgtcgtcga ctttgacccg gacggtcaac gtgctggcct tcgcatggcg aaccgcgttg
3497761 ctgaccgctt cccgaaccac cgcctcggcc tgatcggcga gcgcgctgtc gaccaccgac
3497821 aatggaccca cgaattgaac gctggtgcgc aaccccgagt cggcaaattg ggctacggcc
3497881 gcatcgattc gctgccggag ccgagtgata ccctgcgatg ctccgtgcag gtcataaatg
3497941 gtggtccgga tttcctgtat aacgtcttgc agatcgtcta ccacgtccga gagtcgttgc
3498001 tgcacttcag gattacgttc gtgcgggaca gcaccctgca aagccaggcc aatcgcgaag
3498061 agccgctgga tgacatggtc atggaggtca cgggcgatac gatcccggtc ggtcagtacg
3498121 tcgagttcgc gcatccgacg ttgcgaagtg gccaattgcc aagccagcgc ggcctggtcg
3498181 gcgaacgcgg ccatcatctc gagttgttcg tcggtgaaag cccctggacc gccttgactc
3498241 agcacaacaa cgacacccgc tacggtacct ctggcccgca gcggcaacag cagcgccgga
3498301 cctgcgtcgg ccagttcgtc caggccttcc aaatcgaccc ggtcgacccg tcgcggaatg
3498361 ccgttgacga agacctcccg cagcaccgcg cccgccaccg gaatcgttcg cccaacaatg
3498421 gaagccacag cgctgccgac tgtttcaatc accagcagct cccccacgtc agcggcaggc
3498481 atgtcctcgt cgacgggaac ggctaccagg gcagcgtcag ccgccgtcag cttgagcgcc
3498541 tccgcggcga caagccggaa caccgtcgcg ggttcggtgc cggacaacaa ctcggtggcg
3498601 atgtcacggg tggcctcgat ccacgactga cgcgccttag cctgctggta gagccgggca
3498661 ttcgcgactg cgatacccgc ggcggccgcc agcgcctgga ccagaacctc gtcgtcgtcg
3498721 ctgaacggtt gcccgttggt cttgtcagtc aggtacagag tgccgaacga ttcatcgcgc
3498781 acccgaaccg gtaccccgag gaaggtacgc atcggcggat gatacggcgg aaaaccaatc
3498841 gaggccgggt gcgcagaaac atcgtccagc cgtaacggtt tgggatcttc gatgagcagc
3498901 ccgatgacgc ctaggccttt cggtaggtgg ccgatccgcc gaacggtctc ctcgtcgatg
3498961 ccttcataga caaagtgcaa tacccgatgc tgccggtcgt gcacctccat agcgccatag
3499021 cgcgcatcga caaggctggt cgctgaatgc acgatagcgc gtagggttgc ctccaggtcc
3499081 aggcccgctg tgaccacgag catggcctcc accagaccat cgaggcggtc ccggccctcg
3499141 acgatctgct cgacccggtc ctgcacctcg accagcagct cgtgcaggcg tagttgggag
3499201 agcgtgtgac gcagtggacg cattgcggcg ccgtcgtttt cgtcgacgag gccccctgtt
3499261 gtcatggtcc atcaccgggt ggccgcgagc gcttcaactc cgtcgcgaat accgcggctt
3499321 gcgtccgacg ttccatgccc agcttggcca gcaaccgcga cacgtagttc ttcaccgtct
3499381 tttcggctag gaacattcgg tcggcgatct gcttgttggt caggccctcg ctaagcaggc
3499441 ccagtagcgt ccgctcctgg tcggtaaggc ctgatagcgg gtcctgcttc tcggcggcac
3499501 cgcgcagctt ggccatcagc gcggccgcgg cccgattgtc cagcagcgac cgtccagcgc
3499561 ccacatcttt gacggcgcgc gccaactcca ttcccttgat gtctttgacg acatatccgc
3499621 tggcaccggc gagaatcgca tctagcatgg cctcgtcaga ggtgtaggac gtgaggatca
3499681 gacagcgcag atcgggcatg cgggacaaca gatcgcggca cagttcaatg ccgttgccat
3499741 cgggcaaccg gacatccagc accgcgacat ctgggcgcgc ggcaggaacc ctggccatcg
3499801 cctcggcgac cgaacccgcc tcacctacga cgtcaagctc gggatcggcc ccaagcaagt
3499861 caaccagacc acgacgcacc acctcgtggt catcgaccaa gaagaccttt accaccaggg
3499921 caccactccc aagatccgct ccctacaagt tggcactgcg taccgtaagt acggcgcatc
3499981 cgggctggta tgcaccgcac aattcgtgcg cggagtgtga gtccgcgacg aacagctgac
3500041 ccggctttgc gttggcggcc agatgacggc acgcactgcc gccggcgatg gcccgatcca
3500101 cccgcacctc ggggtagagc cgggtccagt gggcgagccg acggctcagg tgtacatgcg
3500161 ccaaccggct gccctgttcg acgtcatcgg gtgtttcagc agcgtggaca gccacggccc
3500221 gcagcggaac tccgcgcagc ctggcctcct cgaatgcgtg ccgcagcacc acaccattgt
3500281 ccacctccgc gacaaccgcg ctgacctggg aggttgtcgc tggctcggcc ggcgacgggt
3500341 gaatcaccgc cacggggcat aaggccgacc cagccagggt cgccgcgacc gaaccccggc
3500401 gaccgcggac atgatcaagc cccaccgaac cgacgcacag catcgccgcg gacctggact
3500461 cctgcatcag cttggtgagc ggcctgccgc acagaacctc cgtttcgatc ttgaccggtt
3500521 gcccggtggc ctcgaccttc cgagaggcgt cgtgcagcgc cgctcgggcc gctgattgcc
3500581 caccgccctc gccggcggcg gacagttggg acggatcgat gacgtacacc agtcgcagcg
3500641 gaatgtctcg gttcaccgcc tcatcgaccg cccacaacgc cgcatgcgtt gccgcccttg
3500701 acccgtcgat accaacgacc actgcccgag ctggccgagg atcgctcatc gccgtctcct
3500761 tcgctggggc ggatacatcc cgtcggttca gcggtacgtt actggcgggg accgctatct
3500821 cccaggggcg ttggtcccca cctgagggcc gttagtcctt atcgaccgat gacagacgca
3500881 acccgtcagg gcgagaatga atctcaccta tcgcacgggt ggctcgtcca ggtccacaac
3500941 catcgcccag cttttcacag caaagtccca gaaatggctt acagttgccg acagctgccg
3501001 aaccagcggc cgtccatcgg ctgcatatcg cttgacccac agaatatttg ggcatagccg
3501061 cgctgtgaga gcgcatctcg atgcggccgg cacggcgtcg atcaatctcc gatccgccgt
3501121 cagtcgactg ccatacaacc tgcccgccca gttgtacact ggccgcggca cgagttgccg
3501181 cactggtcaa caagtatcag ccggcctgcg cccgagcgga gcccactcgg agccgctcgt
3501241 gaccatgggg ggagccactg ccgtctcccg catgcccaca ccgaggtccg aattgggctg
3501301 ggtgcgcaat cgacgttagg ggcctgcgga gtaatggact acgcgttctt accaccggag
3501361 atcaactccg cgcgtatgta cagcggtccc ggaccgaatt caatgttggt tgccgcggcc
3501421 agctgggatg cgctggccgc ggagttagca tccgcagcag agaactacgg ctcggtgatt
3501481 gcgcgtctga ccggtatgca ctggtggggc ccggcgtcca cgtcgatgct ggccatgtcg
3501541 gctccatacg tggaatggct ggagcggacc gccgcgcaga ccaagcagac cgctacccaa
3501601 gccagagcgg cggcggcggc attcgagcag gctcatgcga tgacggtgcc cccagcgttg
3501661 gtcacaggca tccggggtgc catcgtcgtc gaaacggcca gtgccagcaa caccgctggc
3501721 actccacctt gacccattca gttctcgacc agcacgacac cgtatccgca caaatgtaag
3501781 gagctgagac acaatggatt tcgcactgtt accaccggaa gtcaactccg cccggatgta
3501841 caccggccct ggggcaggat cgctgttggc tgccgcgggc ggctgggatt cgctggccgc
3501901 cgagttggcc accacagccg aggcatatgg atcggtgctg tccggactgg ccgccttgca
3501961 ttggcgtgga ccggcagcgg aatcgatggc ggtgacggcc gctccctata tcggttggct
3502021 gtacacgacc gccgaaaaga cacagcaaac agcgatccaa gccagggcgg cagcgctggc
3502081 cttcgagcaa gcatacgcaa tgaccctgcc gccaccggtg gtagcggcca accggataca
3502141 gctgctagca ctgatcgcga cgaacttctt cggccagaac actgcggcga tcgcggccac
3502201 cgaggcacag tacgccgaga tgtgggccca ggacgccgcc gcgatgtacg gttacgccac
3502261 cgcctcagcg gctgcggccc tgctgacacc gttctccccg ccgcggcaga ccaccaaccc
3502321 ggccggcctg accgctcagg ccgccgcggt cagccaggcc accgacccac tgtcgctgct
3502381 gattgagacg gtgacccaag cgctgcaagc gctgacgatt ccgagcttca tccctgagga
3502441 cttcaccttc cttgacgcca tattcgctgg atatgccacg gtaggtgtga cgcaggatgt
3502501 cgagtccttt gttgccggga ccatcggggc cgagagcaac ctaggccttt tgaacgtcgg
3502561 cgacgagaat cccgcggagg tgacaccggg cgactttggg atcggcgagt tggtttccgc
3502621 gaccagtccc ggcggtgggg tgtctgcgtc gggtgccggc ggtgcggcga gcgtcggcaa
3502681 cacggtgctc gcgagtgtcg gccgggcaaa ctcgattggg caactatcgg tcccaccgag
3502741 ctgggccgcg ccctcgacgc gccctgtctc ggcattgtcg cccgccggcc tgaccacact
3502801 cccggggacc gacgtggccg agcacgggat gccaggtgta ccgggggtgc cagtggcagc
3502861 agggcgagcc tccggcgtcc tacctcgata cggggttcgg ctcacggtga tggcccaccc
3502921 acccgcggca gggtaacccg gcgcctaacc gacaggcggc ccgttgggcg taaacgtcca
3502981 attgtcagga ttcttcggcg agtacaccac cggaagtatt tgaccgacgg tcggccactg
3503041 gtcgacgtcg acggccatgc gctgatacac ggcgtactca ttgaccgtgg gcccagtgat
3503101 gatcccggcg atggtgacat actgctggcc gcctgcgtcc ggtcgcgggc tgactccggt
3503161 caccaggagc gtgccgctgg ccagatctcc ccgcgggccg cgcgggataa gccgcggagc
3503221 aagaaatacc gctaggaccg cgatcagtat gagtagcacg ccaaactccc atcccacccg
3503281 gccatggtag gactgctggc atgagccgtt attacgccga gcgtgaactc agtgcaagaa
3503341 cgcacgcgaa aaatcgcact gggtacacgc tcggcgaaag gatggtgcac cagtgagcca
3503401 cgacgatcta atgcttgcgc tggctctggc cgaccgtgcg gacgaattga cgcgggtccg
3503461 gttcggggcg ctcgatctgc gcatcgacac caaaccggat ttgacgccgg tgaccgacgc
3503521 cgatcgggcg gtcgaatccg acgtgcgcca gacgctgggc cgcgaccggc ccggcgacgg
3503581 cgtcttgggc gaggagttcg gcggatcaac gaccttcacc ggacggcagt ggatcgtaga
3503641 cccgatcgac ggcaccaaaa actttgtgcg cggggtgccg gtgtgggcca gtttgatcgc
3503701 gctgcttgaa gatggcgtcc cgtcggtcgg tgtggtgagt gcgccggcgc tgcaacggcg
3503761 gtggtgggcg gcacgcggcc ggggcgcgtt cgcatccgtc gatggtgcgc gtccacaccg
3503821 gctgtcggtt tcctctgtgg cagagctgca ttcggcgagc ttgtcgtttt ccagtctgtc
3503881 cgggtgggcg cggccgggtc tacgtgaacg cttcatcggg ttgaccgata ccgtgtggcg
3503941 cgtgcgtgct tacggcgact ttctgtctta ctgcctggtg gccgagggcg ccgtcgatat
3504001 tgccgccgaa ccgcaagtgt cggtatggga tctggcggca ctggacatcg tggtgcgtga
3504061 ggcgggcggg cggctcacca gcctggacgg cgtcgccggc ccacacgggg gcagcgccgt
3504121 tgcaaccaac ggtctgttgc acgacgaggt gctgacacgg ctcaacgccg ggtaacctgg
3504181 cgctcgagag cgccatgagc gacccgttca ccatcgcaac caaacactgg caccgactgc
3504241 acgacagccg gatccagtgc gatgtatgtc cacgcgcatg caaacttcac gagggacagc
3504301 gtggcctgtg tttcgtccgc ggccgatttg acgatcaagt gaagctcacc agctacggac
3504361 gctctagcgg attctgtgtc gatccgatcg agaaaaagcc gctcaaccac ttcttgccag
3504421 gttcggcgac gctgtctttc ggcaccgccg ggtgcaacct ggcgtgcaag ttctgccaga
3504481 actgggatat ctccaagtcc cgcgagatcg acgtcctggc cagtcgggcg gccccggccg
3504541 acatcgcccg gaccgcacac gaattgggtt gccgcagcgt ggcattcacc tacaacgacc
3504601 caacgatctt ctgggagtat gccgccgatg tagccgacgc ctgccacgac cagggaatca
3504661 aagccgtcgc ggtgacggcc gggtacatgt gtcctgagcc ccgcgcggaa ttctaccggc
3504721 gtgtcgacgc cgccaacgtc gacctaaagg cattcaccga agacttttat cgcaaggttt
3504781 gcgtcagtca cctgcgcaac gtcctggaca ccctggccta cctgcggcac cagacgaatg
3504841 tgtggttgga gatcaccacc ctgctgattc ccggacgtaa cgacagcgac gcggaagtcg
3504901 ctgccgaatg cagatggatc cgcgaaaacc tgggcgtcga cgtgccggtg catttcaccg
3504961 cgttccatcc cgactacaag atgatggaca ccccggctac accaaccgcc acattgaccc
3505021 gagcccgcga gatcggcatt ggcgaaggcc tgcgcttcgt ctacaccgga aacgttcacg
3505081 atgccgtggg tggcagcacc tcgtgcccag gctgccgggc aacggtgatc gttcgcgact
3505141 ggtattcgat acgacattac gccctcaccg aggacggccg ctgccaagca tgcggctatc
3505201 agatgcctgg cgtgtacgac ggaccggccg gacactgggg ccagcgccgg ctgcccttgc
3505261 tgaccagctt gtcccggatg tgaacaactt aacaagcacc cctatcttac tccggagtaa
3505321 gatagggtgg tccgctatca ccccgatgac cgaggctgcc gtatgaccaa caccacctct
3505381 gctgcaaatg ctgcaaaacc ctccggcgca cgcaccgata gacgcggccg cacgaccggt
3505441 gtcggcctgg cgccccacaa acggaccggc atcgacgtcg cactggcgct gctaaccccg
3505501 attgtcggcc aggagttcct ggacaaatac cgcctgcgcg atccgctgaa ccgatcactg
3505561 cgctacggcg tgaagacgat gtttgccact gccggcgccg ccacccgtca gttccagcgg
3505621 gtgcaaggcc tgcggggcgg accgacccgg ctgaagtcca gcggccgaga ctacttcgat
3505681 ctgacgcccg atgacgacca gaagctgatc atcgagaccg tcgacgaatt cgccgaagag
3505741 gtactgcgac ccgccgcgca cgacgccgac gacgccgcga cctacccgtc cgacttgacc
3505801 gccaaggccg ccgagctggg cattaccgcg atcaacatcc ccgaggactt cgacggtatc
3505861 gccgaacacc gctccagcgt caccaacgtg ctggtggctg aggcactggc gtatggcgac
3505921 atgggcctgg cactgccgat cctggcgcct ggcggggtgg cgtccgcgct cacccattgg
3505981 ggcagcgccg atcagcaggc cacctatctc aaagagttcg ccggcgagaa cgttccgcag
3506041 gcctgcgtgg ccatcaccga accgcagcca ctattcgatc ccacccggct gaagaccacc
3506101 gcggtgcgca ccccgtccgg ttaccggctc gacggcgtga agtcgttgat cccggccgcc
3506161 gccgacgccg agctgtttat tgtcggcgcg cagctgggcg gcaagcccgc actgttcatt
3506221 gtcgagtccg cggccagcgg cctgaccgtc aaggcggatc cgagcatggg gattcgcggc
3506281 gcggcgttgg gccaggtcga actctgcggg gtgtcggtcc cgcttaacgc ccggctgggc
3506341 gaggacgaag ccagcgacaa cgactattcc gaggcgcttg cgctggcccg gttgggttgg
3506401 gcggcgctgg cggtcggtac ctctcacgcc gtgctcgact acgtcgtccc gtatgtgaaa
3506461 caacgccagg ctttcggcga gccgatcgct catcgccaag cggtggcgtt catgtgcgcc
3506521 aacatcgcga tcgagctcga cggcctgcgc ctgatcacct ggcgcggggc gtcccgtgcc
3506581 gagcagggtc tgccgttcgc aagggaagcg gcgctagcca agcggcttgg ctccgacaag
3506641 ggcatgcaga tcggcctgga cggggtgcaa ctgctgggcg gccacggcta caccaaggag
3506701 catccggttg agcgctggta ccgcgacctg cgagccatcg gcgtcgccga gggcgttgtt
3506761 gtcatctaga acgagctgaa agatcaatca tggcaataaa tctggaactg ccgcgcaagc
3506821 tgcaggcgat catcgtcaag acccatcagg gcgctgcgga gatgatgcgg ccgatagccc
3506881 gcaagtacga cctgaaggaa catgcctacc cggtcgaact cgacaccctg atcaatttgt
3506941 tcgagggcgc cgccgaatcg ttcaactttg ccggagccca ttcgcttcgc gacgaggacg
3507001 aaggcaagga cgaaaaccac aacggtgcca acatggccgc cgtggtacag acgatggagg
3507061 ccagctgggg cgacgtcgcg atgatgctgt cgctgcccta tcaggggctg ggtaacgcag
3507121 ccatctccgc ggtagccacc gacgagcagc tggagcggct gggcaaagtg tgggcagcga
3507181 tggccatcac cgaaccggaa ttcggatcgg actcggcggc agtgtcgacg accgccaccc
3507241 tcgacggcga cgagtacgtg atcaacggcg agaagatctt tgtcaccgcc ggttcccgcg
3507301 ccacccacat cgtggtctgg gccacgctgg acaaatcctt gggccgcccg gcgattaagt
3507361 cgttcatcgt gccccgtgag catcccggcg tgaccgtcga acgacttgaa cacaaactcg
3507421 gcatcaaggg ttctgatact gcggtgatcc ggttcgacaa cgcccgtatc cccaagggca
3507481 acctacttgg gaacccggaa atcgaggtcg gcaagggctt tgccggggtg atggagacct
3507541 tcgacaacac ccggccgatt gtggccgcca tggccgtcgg gatcggccgt gccgcactgg
3507601 aggaaatccg tagtgtcctc accggggccg gcgtggagat ctcctacgac aagccctcac
3507661 acacccagag cgccgcggcc gccgagttcc tgcggatgga ggccgactgg gaggccagct
3507721 acctactgtc cctgcgcgca gcctggcagg ccgacaacaa catccccaac tccaaagaag
3507781 cctcgatgag caaggccaag gcgggccgga tggccagcga cgtcacctgc aaaaccgtcg
3507841 aattggcagg aactaccggg tattccgagc aatcactgct ggagaagtgg gcccgcgact
3507901 ccaagatcct ggacatcttc gagggcaccc agcagatcca gcagctggtg gtcgcacgcc
3507961 gactgttggg cctgtcgtcg tccgagctca aatagcctcg gcgagcagac gtcaaagccc
3508021 ccgaatttca gtgaaatcgg gggcttttgc gtctgctggc gcccgtctgc acccccgcca
3508081 gtaggctggt cggcatgcgc gcggtacggg tgactcggct ggagggacca gatgcggtcg
3508141 aggtggccga ggtcgaggaa cccacgagcg ccggtgtggt catcgaggtg cacgctgccg
3508201 gcgtggcctt cccggacgca ctgctaaccc gtggccgtta ccagtaccgc ccggagccgc
3508261 cattcgtgct cggcgccgag atcgccggag tggttcgatc ggcgccggat aacagccaag
3508321 tgcgttccgg agacagggtt gtcggcctca cgatgctcac cggcggcatg gccgaagtcg
3508381 cggtattgtc gcccgagcgc gtgttcaagc tgccggacaa catgactttc gaggcgggcg
3508441 cgggcgtgct gttcaacgac ctgacggtgt acttcgcgct ggcggtccgg ggccggctgc
3508501 aggccggtga gacggtgctg gtgcacgggg cggcaggcgg gatcggcaca tcgacgttgc
3508561 gactagcgcc ggcgctcggg gcgtctcgca ccgtcgcggt ggtcagcacg caggagaagg
3508621 ccgagcttgc gacagtggcc ggggcgacag atgtggtgtt ggccgagggg ttcaaggacg
3508681 cggtacagga gctgacgaac ggccgtggtg tcgacatcgt cgtagacccg gtcggcggcg
3508741 accggttcac cgattcgctg cgctcgcttg ctgcgggagg acggctgttg gtcatcggct
3508801 tcactggcgg cgagattccc accgtgaagg taaaccgcct tctgctcaac aacattgacg
3508861 ttgtcggggt aggctggggc gcctggtcgc tgacccaccc cgatgcgctg gcccagcagt
3508921 ggtcacaact cgagcggctg ctacgctcgg gcaagctgcc tcctcccgaa ccagtggtct
3508981 acccactgga ccaagccgct gcggcgattg catcgctgga gaatcgcacc gccaagggga
3509041 aggtcgtact acgcgtgcgc gactaacgcc cctcccggga cgcgtcgccg gcgtgctctg
3509101 gccaatttgc cgcttcctca ctggtcgccg ttggcgtcgg ctacgtcatg ccgcacaact
3509161 cgcagcttgc ctggcgccag gcacgcggcg tatccgtggt atttgccata cagttcccat
3509221 gcggtgacgc gatcatcggg gtgcacgtcg atctgatgac cgtcggagaa ctcaagatgg
3509281 agatctccgg tgtcatacca gacgaaagct gtgcaggttg ccccggcgaa atcgaagagc
3509341 ggacgctcgt ggtcggctgg gtcgtttggg tcgatggcga ccacttctgc gggcgaggtt
3509401 tcgatggccg gcagagtcag ctgtagtggt accgagatga ccagctcgtt gtaatcgtcg
3509461 aagttcagca ccagaccgtc gcggaacata atccgctgaa ccgcacagcc ctctaaccac
3509521 tgctcggtca tttcctgttc ggtcatatat tcactctggc cttgttgtgc ccatatgtca
3509581 cgtacacaac cgccgaaatc tcgtgcggga ttacacccta ggcgtccgat ggacaccagt
3509641 accatctgac accgtgcccg actccagcac cgcattgcgg atcctcgtct acagcgacaa
3509701 cgtccagacc cgcgaacggg tgatgcgggc cctgggcaaa cggttgcacc cggatctgcc
3509761 cgatttgacc tacgtcgaag tggctaccgg tccgatggtg atacgccaga tggatcgggg
3509821 gggcatcgac ttggccatcc tcgacggtga ggcgacaccg accggaggca tgggaatcgc
3509881 caaacagctc aaagacgaac ttgccagttg cccgcccatc ctggtgctca ccggccgtcc
3509941 ggacgacacc tggctggcca gctggtcgcg ggccgaggcc gcagtgccgc atcccgtcga
3510001 ccccatcgtg ctgggccgca cggtgctctc actgttgcgc gcacccgccc actaaccgga
3510061 cgcggccggc attcgcggcg cgaacgttca gccgccccgc atttgaatct tcgggtcctt
3510121 tcttacccga ggtcgtaatt ggcccgctgc cgcttccggc cgcaacgacg gcgctgtctc
3510181 ctccgccgct gaagtctctg aagcctgctg accttgcgcg gtgcgtagtg tcgattccgg
3510241 aattccagaa cccgcggatt ggcctacccg cgttgtcgac agcggagcgg ccttggccgc
3510301 aactttcgga tccacagttg gcagcacccc cattgctgga acttcaagtt ctggaacttc
3510361 cacaacggct tccggtggcg cggaagccgc cggctctggc gctcgagctg actcggtggc
3510421 agttcccggg gcagagttag tgccgccacg tgccatctga cccagagcgg cgagcgcgag
3510481 cggggcaccg atgaagccgg ggctcacaac gccggcatgg gcactggtag cgctcgacgc
3510541 gacgacgtct ccggcgccaa catcgccacc gccgaaattc ccttggccta cactgccatg
3510601 ggccggatca ccggccgcta acccggcgct agccacgccg cctccgacgt agccgacgcc
3510661 cccgccgcta gcggttgcac ctccggtgcc gacgctctca ccgccgccgg tgccgacgct
3510721 ctcgccgcca gtagcgccgg tgccgacgct ctcaccgcca gtagcgccgg tggcgccggc
3510781 acccaaaccc ggaaatcgct gcagcaaact cgcccacggc accacttgcg cggcaatcgc
3510841 cgatgccccg gagtagtacc ccgacatggc ggccacatcc gcggcccaca tctcctcgta
3510901 cacaccctcg gcggcagcaa tcaacggcgc gttctgcccg aacaaattcg tcatcaccag
3510961 ctgcacgaat gcgtcgcggt tggcggccac cgccgccgga agcaccgtcg ccgcctgcgc
3511021 cgcctcgaag atgctggcca ctgcgcgcgc ctgtcccgcc gccccggccg actgagccgc
3511081 tgccgcggtc aaccaccccg cgtagggagc cgccgctgcc gccatcgcca aggctgccgg
3511141 accctgccac gcctgacccg ccagcccggc cgtgaccgac gcaaatgatt gcgccgcggt
3511201 ccccaactct tcggcaagcc cgtcccaggc tgccgccgcc gccagcatcg gcgcagtgcc
3511261 tgcaccgatg aacattcgca aggaattgat ctccggcggc agcacgacga aactcacagc
3511321 tcccgtcctt ccgcttcgct gctcgatgcc acgccgacct caatacggcc aacgattaac
3511381 cggcaaatgc cgagattaac aacaaatgct gcgcttatca gggggttaga ccaacattca
3511441 tacaattcgc cgggacgcgc aatccccagt tttgcttcgc agcgaccgac gccggaccca
3511501 gccacgggtt ctgcttcgac tcgcacaggt atgcaccagc ctgaccccgg gaatgtgggg
3511561 tggccgttgc gcgactatgt tgaaggtcac tgtgacggcc cgaagccccg gttcgtcacg
3511621 gcagcccggt caccgcccgg ccgccgcgct ggcggccccg tacgacggat catggagcga
3511681 gttgaacgtc tacataccca tcctggtact ggcggcgctg gccgccgcct tcgccgtggt
3511741 gtcggtggtg atcgcgagcc tggtcggccc gtcgcggttc aaccggtcaa agcaggccgc
3511801 ctacgaatgc gggatcgagc ccgctagcac tggagccaga acctccattg gccccggcgc
3511861 ggcgagcggg cagcggttcc ccatcaagta ctacctgacc gcgatgttgt tcatcgtctt
3511921 cgacatcgaa attgtgttcc tctacccgtg ggcggtcagc tacgactcgc tgggcacgtt
3511981 cgcgctggtc gagatggcga tattcatgct cacggtgttc gtggcctacg cgtatgtgtg
3512041 gcgccgcggg ggcctgacgt gggattgagg tagggcgtgg gactggaaga acagctgccc
3512101 ggcgggatcc tgctgtcgac cgtcgagaag gtggcgggct atgtccgcaa aaactccctg
3512161 tggccggcaa cattcggatt ggcgtgctgt gcgatcgaga tgatggcgac cgcgggacca
3512221 aggtttgaca ttgcgcggtt cgggatggaa cggttctcgg ccacgccgcg gcaggcagat
3512281 ctgatgatcg tggcgggccg ggtcagccag aagatggcgc cggtactgcg ccagatctat
3512341 gaccagatgg cggagccgaa atgggttctg gccatgggtg tgtgcgcctc gtcaggtggg
3512401 atgttcaaca actatgcgat cgtgcagggc gtggatcatg ttgttccggt cgacatctac
3512461 ctacccggct gcccgccgcg cccggagatg ctgctgcacg caatcctgaa gctgcacgaa
3512521 aagattcagc agatgccatt aggtatcaac cgggaacgcg ctatcgccga ggccgaagag
3512581 gcggcgttgt tggcccggcc caccatcgag atgcgcggac tgctgcgatg agcccgccga
3512641 accaagacgc ccaggaaggc cgcccggact cccccaccgc ggaggtggtc gacgttcgcc
3512701 gcggcatgtt cggcgtctcg ggcaccggtg acacctccgg ttacggacgg ttggtgcgcc
3512761 aagtcgtcct ccctggcagc agcccccggc cctacggcgg ctacttcgac gatatcgtcg
3512821 accggctggc cgaggcactg cggcacgagc gcgtcgaatt cgaggacgcc gtcgagaaag
3512881 tcgtggtcta ccgcgatgaa ctgaccctgc acgtccgccg ggatctactg ccgcgggtcg
3512941 cccagcggct gcgcgacgaa cccgaattgc gattcgagct gtgtcttggg gtgagcgggg
3513001 tgcactaccc gcacgagacg ggtcgggagc tgcatgccgt ctacccgctg cagtcgatca
3513061 cccacaaccg tcgcctccgg ttggaagtgt ctgcgccgga cagtgatccg cacatccctt
3513121 ccctgttcgc gatctatccg accaacgact ggcacgagcg ggaaacctac gacttcttcg
3513181 ggatcatctt cgacggccat ccggccctga cccggatcga gatgcccgat gactggcagg
3513241 ggcatccgca acgcaaggac taccctctcg gcggcatccc ggtcgaatac aagggcgcgc
3513301 agataccccc gcccgacgag cggaggggct acaactgatg acggcaatcg ccgactcggc
3513361 tggcggcgcc ggcgagaccg tcctggtcgc tggcgggcag gactggcagc aggtcgtgga
3513421 cgccgcgcgc agcgcggatc ccggtgaacg catcgtcgtc aacatggggc cccagcaccc
3513481 gtctacccac ggggtgttgc ggttaatcct ggagatcgag ggcgaaacag tcgtcgaagc
3513541 ccggtgcgga atcggctacc tgcacaccgg aatcgagaag aacctcgaat accggtactg
3513601 gacccagggc gtcaccttcg tgacccgaat ggattacctg tcaccgtttt tcaacgaaac
3513661 cgcctactgc ctcggcgtgg agaagctgct cggcatcacc gatgagatac ccgagcgggt
3513721 caacgtcatc cgcgtgctga tgatggagct caaccggatc tcgtcgcatt tggtcgcatt
3513781 ggcgaccggg ggcatggaat tgggcgccat gactccgatg ttcgtcggct tccgggcacg
3513841 cgagatcgtg ctcacgctgt tcgaaaagat caccggtttg cggatgaaca gcgcctacat
3513901 ccgacccggc ggcgtggcgc aggacttacc gcccaacgcg gccaccgaaa tcgcggaagc
3513961 actcaagcag ttgcgccaac cactgcgcga aatgggcgag ctgctcaacg aaaacgccat
3514021 ctggaaggcc cgcacccagg gcgtcggata cctggatctg accggatgca tggcactggg
3514081 catcaccggc ccgatactgc gttccactgg gttgccccac gacctgcgga aaagcgagcc
3514141 ctactgcgga taccagcact atgaattcga tgtgatcacc gacgacagct gtgatgccta
3514201 cgggcgctac atgattcgcg tcaaagagat gtgggagtcg atgaagatcg tggagcagtg
3514261 tctggacaag ttacgacccg gcccgaccat gatctccgat cgcaagctcg cctggccggc
3514321 cgacctgcag gtggggcccg acggcctggg caactcaccc aagcacatcg ccaaaatcat
3514381 gggctcctcg atggaagcgc tgatccacca cttcaaactg gtcaccgagg gcatccgggt
3514441 gccggcgggc caggtctacg tcgcggtgga gtccccccgt ggtgagctcg gcgtacacat
3514501 ggtcagcgac ggtggcaccc gcccctaccg ggtgcactac cgggatccct ccttcaccaa
3514561 cctgcagtcc gtcgccgcga tgtgcgaagg cgggatggtc gccgatttga tcgcggcggt
3514621 cgccagcatt gacccggtca tgggcggggt ggaccggtga cacagccacc cggtcagccg
3514681 gtgttcatcc ggctcggacc gccaccggac gaacccaacc agtttgtcgt cgagggcgct
3514741 ccgcggtcgt atccgccgga cgtactggcg cggctggagg tcgacgccaa ggagatcatc
3514801 ggccgctatc ccgacaggcg ctcggcgctg ttgccgttgc tgcacctggt gcagggcgag
3514861 gattcctacc tgacgccggc gggtttgcgg ttctgcgccg atcaactcgg gctgaccggg
3514921 gccgaggtgt cggcggtggc cagcttctac accatgtacc gccggcgccc caccggcgag
3514981 tacctggtgg gtgtgtgcac gaacacgctg tgcgccgtca tgggcggcga cgccatcttc
3515041 gaccgcctca aagagcatct cggcgtcggc cacgacgaaa ccacctccga cggtgtggtc
3515101 accttgcaac acatcgaatg caacgccgcc tgcgattacg caccggtggt gatggtcaac
3515161 tgggaattct tcgacaacca gacgccggag tccgcgcgcg aactcgtcga ctcgctgcgc
3515221 tccgacacac cgaaggcgcc cacccgcggc gcgccgctgt gcggcttccg gcaaacatcg
3515281 cgcatcctgg cgggtctacc cgaccagcgt cccgacgaag gccagggcgg tcccggcgcg
3515341 cccaccctgg ccgggctgca ggtggcaagg aagaacgaca tgcaggcgcc accaaccccc
3515401 ggagcggacg aatgaccacg caggccaccc cgttgacccc ggtgatcagc cgccactggg
3515461 acgacccgga gtcgtggacc ctggccactt atcaacgcca cgatcgctat cggggctatc
3515521 aggcgttgca gaaagccctg acgatgccgc ccgacgacgt gatcagcatc gtcaaggatt
3515581 ccgggttacg cggacgcggc ggcgcgggct ttgccaccgg gaccaagtgg tcgttcatcc
3515641 cgcagggcga caccggcgcc gcggccaagc cgcactacct ggtggtcaac gccgacgagt
3515701 ccgaacccgg tacgtgcaaa gacattccgt tgatgctggc gacgccacat gtgctcatcg
3515761 aaggcgtcat catcgccgcc tacgcgatcc gcgcccatca cgcgttcgtc tacgtacgcg
3515821 gtgaggtggt gccggtattg cgccggctgc acaacgcggt ggccgaggcc tatgccgccg
3515881 gcttcctagg ccgcaacatc ggaggttccg gattcgatct ggagctggtg gtacacgccg
3515941 gcgcgggcgc ctacatctgc ggcgaggaga ccgccctgct cgactcgctg gaaggccggc
3516001 gcggccagcc gcggctgcgg ccccccttcc ccgcggtggc cggtctgtat ggctgcccga
3516061 ccgtgatcaa caacgtcgaa acgatcgcca gtgtcccatc gatcatcctg ggcggcatcg
3516121 actggttccg gtcgatgggc agcgagaaat cgcctggctt caccctgtat tcgctgtccg
3516181 gccacgtcac ccgccccggc cagtacgagg cgccgctggg cattacgctg cgcgagttgc
3516241 tcgactacgc aggcggggtg cgcgccgggc accggctgaa gttctggaca ccgggcggct
3516301 cgtcgacccc gctgctcacc gacgagcatc tggatgtgcc gctggactac gagggtgtgg
3516361 gtgcggccgg ctcgatgctg gggaccaagg cgctggagat cttcgacgag accacctgcg
3516421 tggtgcgcgc ggtgcgccgc tggaccgagt tctacaagca cgaatcgtgt gggaaatgca
3516481 cgccgtgccg ggagggcacc ttctggctgg ataagatcta cgagcggctg gaaaccggcc
3516541 ggggtagcca tgaagacatt gacaaactgt tggacatttc cgattccatc ttgggaaagt
3516601 cgttctgcgc gttgggcgac ggtgccgcga gtccggtgat gtcgtcgatc aagcacttcc
3516661 gcgacgagta cctggcccac gtcgaaggag gcggttgccc attcgacccc cgagactcca
3516721 tgctcgtcgc gaacggagtg gacgcgtgac ccaggcggcc gacactgaca tccgggtagg
3516781 ccaaccggag atggtgacac tgaccatcga cggcgtcgaa atcagcgtcc ccaagggcac
3516841 gttggtgatt cgcgccgccg aactgatggg aatccagatc ccgcgattct gcgaccaccc
3516901 gctgctggag cccgtcggcg cctgccggca atgcctggtc gaggtcgaag ggcaacgcaa
3516961 gccgctggcg tcgtgcacca ccgtggccac cgacgacatg gtggtgcgca cccaactcac
3517021 ctccgagatt gccgacaagg cccagcacgg tgtgatggaa ctgctgctga tcaaccatcc
3517081 gctggattgc ccgatgtgcg acaagggcgg tgaatgcccg ctgcaaaacc aggcaatgtc
3517141 taacggccgc acggattctc gcttcaccga ggccaaacgt accttcgcca aaccgatcaa
3517201 catctccgcg caggtgctgc tggaccgcga acgttgcatc ctgtgcgccc gctgcacccg
3517261 gttctccgac cagatcgccg gcgatccgtt catcgatatg caggagcgcg gcgccctgca
3517321 gcaggtcggt atctacgccg atgaaccgtt cgagtcgtac ttctccggca acacggtgca
3517381 gatctgcccg gtgggggcgc taacggggac cgcctaccgg ttccgcgcgc gtccgttcga
3517441 tttggtctcc agccccagcg tctgcgagca ctgcgcgtcg ggctgcgcgc aacgcaccga
3517501 ccatcgccgc ggcaaggtgc tgcggcggct ggccggtgac gacccggaag tcaacgagga
3517561 gtggaactgc gacaagggcc ggtgggcctt cacgtacgcg acccagccgg acgtgatcac
3517621 cactcccctg atccgcgacg gtggggaccc caagggcgcg ctggtgccca cctcgtggtc
3517681 gcacgcaatg gcggtggccg cccagggact ggcggcagcg cggggccgca ccggggtgct
3517741 ggtcggcggc cgagtgacct gggaggacgc ctacgcgtac gccaagttcg cgcggatcac
3517801 gttgggcacc aacgacatcg acttccgcgc ccggccgcac tcggccgagg aggccgactt
3517861 cctggcggcc cgcatcgccg ggcggcatat ggcggtcagc tatgccgatt tggaatcggc
3517921 tccggtggtg ctgctggtgg gattcgagcc cgaagacgag tcgccgatcg tgtttctgcg
3517981 gttacgcaag gccgctcgca gacaccgcgt cccggtgtac acgatcgccc cctttgccac
3518041 tggtggcctg cacaaaatgt cgggccggct gatcaaaacc gttcctggtg gcgaacccgc
3518101 ggcgctggac gatctggcca ccggtgcagt gggcgacctg ctggccaccc cgggcgcggt
3518161 catcatagtc ggggagcgct tggccacggt accgggcgga ttgtcggcgg ccgctcggct
3518221 ggccgatacg accggcgccc gtttggcgtg ggtgccgcgg cgggcggggg aacgcggagc
3518281 gctggaagcc ggagcgttgc ccacgctgtt acccggtggc cgcccgctgg ccgacgaggt
3518341 cgcccgcgcg caggtgtgtg cggcgtggca tatcgccgaa ttgcctgccg cggctggacg
3518401 ggacgccgac ggcatcctgg ccgccgctgc cgacgagacg ttggctgcgc tgctggtcgg
3518461 gggtatcgaa cccgcggact tcgccgaccc ggacgccgtg ctggccgcgt tggacgccac
3518521 cggtttcgtg gtcagcctgg agctgcgaca cagtacggtc accgaacgcg ccgacgtggt
3518581 gttcccggtc gcgccgacga cccagaaagc cggcgcgttc gtcaactggg agggtcgcta
3518641 ccgtacattc gaacccgcgc tgcgcggcag cacactgcaa gctggccagt cggatcaccg
3518701 ggtgctggac gcgttggccg acgacatggg tgtccatctg ggcgtgccca ccgtggaggc
3518761 ggcccgcgag gagctggccg cgctcggtat ctgggacggc aaacacgctg ccggtcccca
3518821 catcgcggcc accgggccga cccaacccga agctggtgag gcgatcttga ccgggtggcg
3518881 gatgctcctc gacgagggcc gcctgcagga cggcgaacca tatctggccg gtaccgcgcg
3518941 cacacccgtg gtacggctgt cgccggatac ggcagccgag atcggcgccg ccgatggcga
3519001 ggcggtcacg gtcagcacgt cacgcggctc aatcaccttg ccgtgcagtg tcaccgacat
3519061 gcccgaccgc gtcgtgtggc ttccgctgaa ctcggcgggc tcgacggtgc accgacagct
3519121 gagggtgaca atcggcagca tcgtgaaaat cggagcgggc tcatgagcgt ctccccttgc
3519181 cgcgagcgcg cgtgttcccc cgcaagcggg aggtgccccc agtacgccga cacaccgatt
3519241 ttgatgtacc agtgcggacc ctcgcgcaag gagtggcggc catgaccacg ttcggccacg
3519301 acacctggtg gctggtggcg gccaaagcga tcgcggtatt cgtgttcctc atgctgacgg
3519361 tgctggtggc gatcctggcc gaacgcaagc tgctgggccg gatgcagttg cggcccggcc
3519421 ccaaccgggt tggcccaaaa ggagccctgc agagcctggc tgacggcatc aagctggcgc
3519481 tcaaagagag catcacaccc ggtggcatcg atcgattcgt atattttgtg gcgccgatca
3519541 tttcggtgat tccggcattc accgctttcg cgttcatccc gtttggtccc gaggtgtcgg
3519601 tgtttggcca ccggacaccg ttgcagataa ccgaccttcc cgtcgccgtg ctgttcatcc
3519661 tgggactgtc ggcgatcggg gtatacggca tcgtgctggg cggttgggcg tccgggtcca
3519721 cctacccgct gctgggcggg gtgcgctcca ccgcgcaggt catctcctac gaggtcgcga
3519781 tgggcctgtc gttcgcgacg gtgttcctta tggccggcac catgtcgacg tcgcagatcg
3519841 tggccgcaca agacggtgtc tggtatgcct tcctgttgtt gccgtcattc gtcatctatc
3519901 tcatttctat ggtgggtgaa accaaccggg cgccgttcga tttgcccgaa gccgagggcg
3519961 agctggtcgc gggattccac accgagtact cgtcgttgaa gttcgcgatg ttcatgctcg
3520021 ccgagtacgt caatatgact acggtttcgg cactggccgc gaccctattc ttcggtggct
3520081 ggcatgctcc ctggccgctg aacatgtggg cgagcgccaa caccggctgg tggccactga
3520141 tctggttcac cgctaaagtg tggggctttc tgttcatcta tttctggctg cgggctacgc
3520201 tgccgcggct gcgctacgac cagttcatgg cgctgggctg gaagttattg atccccgtct
3520261 cgctggtgtg ggtgatggtc gccgcgatca tccgctcact acgcaaccag ggctaccagt
3520321 actggacccc gactctggtg tttagcagca ttgtcgttgc cgctgccatg gtgctgttgt
3520381 tgcgaaagcc gttgagcgct cccggcgctc gcgcatcggc acggcaacgc ggggacgaag
3520441 gcaccagccc tgaaccggca tttccgacac caccgctgct agccggtgca accaaggaga
3520501 atgcaggtgg ctaacactga tcgtccggct ctcccccaca agcgggcggt acccccatct
3520561 cgggctgact ccggcccgcg tcgtcgccgg actaagttac tggacgccgt agccggattc
3520621 ggggtaacgc ttggttcgat gttcaaaaag acggtcaccg aggagtatcc ggaaaggccc
3520681 ggtccggtag cagcgcgcta ccacggccgt catcagctca accggtatcc ggacggcctg
3520741 gagaaatgca tcggctgcga gttgtgcgcc tgggcctgcc cggccgacgc aatctatgtc
3520801 gagggcgcgg acaataccga agaggagcgg ttttcgccgg gcgaacgcta cggccgggtg
3520861 taccagatta actatttgcg ttgcatcggt tgcggtttgt gcatcgaggc gtgcccgacg
3520921 cgggcgctga cgatgaccta tgattacgaa ctggccgacg acaaccgcgc cgacctgatc
3520981 tacgagaagg accggctgct ggccccgctg ctgcccgaga tggccgcgcc gccgcatccg
3521041 cggacgcccg gtgccaccga taaggactac tacctaggca atgtgaccgc cgagggcttg
3521101 cggggcgtgc gtgagagcca gaccaccgga gattcccgat gaccgcggtg ctggcttcag
3521161 atgtcatcgt ccgcacctcc accggggaag cggtgatgtt ctgggtgctc agtgcgttgg
3521221 cgctgctggg cgcggtcggg gttgtgctgg ccgtcaacgc cgtgtactca gcgatgtttc
3521281 tggcgatgac catgatcatc ctggcggtgt tctacatggc ccaggacgcg ctgtttttgg
3521341 gtgtcgtcca ggtggttgtc tacaccggcg cggtgatgat gctgttcctg ttcgtgctga
3521401 tgctgatcgg tgtggactcc gcggaatcac tgaaggagac gctgcgcggg cagcgggtcg
3521461 ccgcggtgct gaccggtgtc gggttcggcg ttctcctgat cagcaccatc ggccaggtgg
3521521 cgacccgagg ttttgccgga ctaaccgtcg ccaacgccaa cggcaacgtc gaaggcttgg
3521581 ccgcgctgat tttttcccgt tacctgtggg cgttcgagtt gaccagtgcg ctgttgatta
3521641 ccgccgccgt cggggcgatg gtgctagcgc accgggagcg tttcgagcgc cgcaagaccc
3521701 agcgcgaact ctcccaggaa cgcttccgtc ccggcgggca ccccaccccg ctgcccaacc
3521761 cgggtgtcta cgcgcgccac aacgcggtcg acgttgccgc cctgctcccc gacggttcct
3521821 attccgaatt gtcggtcccc cggatgctgc gcacccgcgg ggccgacggc ctgcaaacac
3521881 cctcgcccgg agccgtctcc ggctctttag aaggcggtgc atcatgaatc cggccaacta
3521941 cctttatctt tcggtgctgc tattcaccat cggagcctcc ggtgtgctgc tgcgacgcaa
3522001 cgcgatcgtg atgttcatgt gcgtcgagct catgctcaat gccgttaacc tggcgttcgt
3522061 caccttcgcg cgcatgcatg gccatctcga cgcccagatg atcgcgttct tcaccatggt
3522121 ggtggccgcc tgcgaagtgg tcgtcggcct ggccatcatc atgacgattt tccgtacccg
3522181 caaatcggcg tcggtcgacg acgcgaatct actcaaaggc tgacgacgcc accgtgacaa
3522241 cttccttggg gactcactac acctggctgc tggtggcact gccactggcg ggtgccgcaa
3522301 tcttgctgtt cggcggcaga cgcaccgatg cgtggggcca cctgctgggc tgtgccgcag
3522361 cgctggcggc attcggggtg ggcgcgatgc tgctggccga catgctcggt cgcgatgggc
3522421 tcgagcgcgc gatccatcag caggtgttca cctggatacc cgccggcgga ctccaagtcg
3522481 acttcgggct gcagatcgat cagttgtcca tgtgcttcgt gctgctgatc tccggggtcg
3522541 gatcgctgat tcacatctat tcggtcggct acatggccga ggacccggac cggcgcaggt
3522601 ttttcggcta tctcaacctg tttctggcct cgatgctgct gctggtggtc gccgacaact
3522661 atgtgttgct gtacgtcggc tgggagggtg tgggcctggc gtcgtatctg ttgatcggtt
3522721 tctggtacca caagccgtcg gcggccaccg cggccaaaaa ggcattcgtg atgaaccggg
3522781 ttggggacgc cggcctagcg gtgggtatgt tcttgacgtt tagcactttc ggcaccctgt
3522841 cgtatgccgg cgtgttcgcc ggcgtacccg ccgcaagtcg cgcagtgctg accgcgatcg
3522901 ggttgttgat gctgttgggg gcgtgcgcca agtccgcgca ggttccgctg caagcctggc
3522961 ttggcgacgc gatggagggc cccaccccgg tgtccgcgct gatccacgcc gccaccatgg
3523021 tgaccgccgg agtgtatttg attgtgcggt cgggcccgct gtacaacctg gcgcccaccg
3523081 cccaactggc ggtcgtcatc gtcggcgcgg tgacgctgct gtttggggcg atcatcggct
3523141 gcgccaagga cgacatcaaa cgtgcgctgg cagcctcgac cattagccag atcggctaca
3523201 tggtgctggc cgcgggcctg ggtccggccg gctacgcgtt tgcgatcatg catctgctca
3523261 ctcacggttt cttcaaggcc ggcctattcc ttgggtccgg cgcggtgatt cacgcgatgc
3523321 acgaagagca ggacatgcgc cgttacggtg gtctgcgcgc cgccctgccg gtcacgttcg
3523381 caaccttcgg cctggcgtat ctggcgatta tcggggtacc gccgttcgcg ggcttcttct
3523441 ccaaggatgc gatcatcgag gccgcattgg gcgccggcgg catccggggc tcgctgctgg
3523501 gcggtgccgc gctgctgggt gcgggcgtca ccgcgttcta catgacgcga gtgatgctga
3523561 tgaccttctt cggcgaaaag cgttggacgc caggcgccca tccgcacgag gcaccggccg
3523621 tgatgacctg gccgatgatc ttgctcgccg tcggctcggt gttctccggt ggcctgctcg
3523681 cggtgggtgg cacgttgcgg cattggctgc agccagttgt cggatctcat gaagaggcca
3523741 cccatgcgct gccgacctgg gtcgccacca ccctggcgct cggtgtggtc gccgtcggta
3523801 tcgcggtggc ctaccggatg tacggcaccg cgccgatccc gagggttgcc ccggttcggg
3523861 tgtcggcgct gaccgcggcc gcacgtgcgg acctgtacgg cgatgccttc aacgaggagg
3523921 tgttcatgcg ccctggtgcg caattgacca acgcggtggt cgcggtggac gacgcgggtg
3523981 tggacggctc ggttaacgcg ctggcgacgc tcgtgagcca gacttcgaat cgcctgcggc
3524041 aaatgcaaac cggcttcgcc cgtaactacg cgttatcgat gctggtagga gcggtgttag
3524101 tggcggcggc gctgctggtg gtgcagctgt ggtgaataac gtgccgtggc tgagcgtgct
3524161 ctggctggtg ccgctggcag gtgcggtgct gatcatcctg ctaccacccg gtcggcgccg
3524221 actcgccaag tgggccggta tggttgtcag cgtcctgacg ttggcggtgt cgatcgtcgt
3524281 cgcggccgaa ttcaagccca gcgccgagcc gtatcagttc gtcgaaaagc attcctggat
3524341 accggcgttc ggcgccggct atacccttgg tgtggacggc atcgcagtgg tgctggtgtt
3524401 gttgaccaca gtgctgattc cgttgctgct ggtggccggc tggaacgacg caaccgatgc
3524461 tgacgacctg tcccccgcaa gcgggaggta cccccagcgc ccggctccgc cgcgcttgcg
3524521 atcgtcaggt ggcgaacgca cccgaggcgt gcacgcctac gtggcattga cgctggccat
3524581 cgagtcgatg gtgctgatgt cggtgatcgc gctggacgtg ctgctgttct acgtgttctt
3524641 cgaggccatg ctgatcccga tgtacttcct catcggcggc ttcggccagg gggccggacg
3524701 ctcgcgtgcc gcggtgaagt tcttgctgta caacctgttt ggcgggttga tcatgctggc
3524761 ggcggtgatc gggctgtatg tggtgaccgc acagtacgat tcgggcacct tcgacttccg
3524821 tgagatcgtg gccggcgtgg cggcgggccg ctacggagcg gacccggcgg tgttcaaggc
3524881 gctgttcttg ggcttcatgt tcgcgttcgc gatcaaggct ccgctgtggc cgttccatcg
3524941 ctggctgccg gacgccgccg tcgagtccac cccagcgacc gcggtgctga tgatggcggt
3525001 gatggacaag gtcggcacct tcggcatgct gcgctactgc ctgcagctgt ttcctgaccc
3525061 gtcaacgtat ttccgtccgc tgatcgtgac gctggccatc atcggggtga tctacggcgc
3525121 gatcgtggcg atcggccaaa ccgacatgat gcggctgatc gcctacacct cgatctcgca
3525181 cttcgggttc atcatcgcag gcatcttcgt catgaccacc cagggccaga gcgggtcgac
3525241 gctgtacatg ctcaaccacg gcctgtccac ggcggcggtg ttcctgatcg ccggtttctt
3525301 gatagcgcgg cgcggcagcc gatcgatcgc cgactacggc ggtgtccaga aggtggcgcc
3525361 catcctggcc ggcacgttca tggtctcggc catggccacc gtatcgctgc ccggcctagc
3525421 cccgtttatc agcgaattcc tggttctgct gggcactttc agccgctact ggctggcggc
3525481 ggcgttcggc gttaccgcac tggtcctctc ggccgtttac atgctgtggc tctaccagcg
3525541 ggtgatgacc ggtccggtag ccgaaggcaa cgaacgcata ggggatctgg tgggccgcga
3525601 gatgatcgtg gtggcaccgt tgatcgcgct gttactcgtg cttggggtct accccaaacc
3525661 tgtgctcgac atcatcaatc cggcggtcga gaacaccatg accaccatcg gccagcatga
3525721 tcccgcgccc agcgtggcac acccggttcc ggccgtgggc gcctcccgga cagccgaagg
3525781 accgcaccca tgatcctgcc cgccccgcac gtcgagtact tcctgctcgc tccgatgctc
3525841 atcgtctttt cggttgcggt cgccggtgtg ctggccgagg ctttcctgcc gcgccggtgg
3525901 cgctatggcg cccaagtgac gctcgccctt ggcgggtcgg cagtggcact catcgcggtc
3525961 atcgtggtgg ccaggtcgat tcacgggtcg ggtcacgccg cggtgctggg ggccatagcc
3526021 gtggatcgag cgaccctgtt tctgcaaggc accgtactac tggtcacgat catggcagtc
3526081 gtcttcatgg ccgaacgcag cgcccgggtg agtccgcaac gccagaacac cctcgctgtg
3526141 gcgcggctcc ctggactcga ttcgtttacc ccgcaggctt ccgccgtgcc cggcagcgat
3526201 gctgagcgcc aagcggaacg ggcgggagcc acccagacgg aacttttccc gctggcgatg
3526261 ctgtccgtcg gcggcatgat ggtgtttccc gcgtccaacg acctgttgac gatgttcgtt
3526321 gcgctggagg tgctatcgct gccgctgtac ctgatgtgtg ggctggcccg gaatcgccgc
3526381 ctgctgtcgc aggaagccgc gatgaagtac ttcctgctgg gcgccttctc gtcggcgttc
3526441 ttcctctacg gcgtcgcgtt gctatacggc gcgaccggca cgctgacctt gccgggtatt
3526501 cgggatgcgt tggcagcgcg caccgacgac tcaatggcgt tggccggcgt cgcgctgctc
3526561 gcggtcggcc tactattcaa ggtcggcgcg gtgccattcc actcctggat tcccgatgtg
3526621 taccagggcg cacccacccc gatcaccggg ttcatggcgg ccgccaccaa ggtcgcggcg
3526681 ttcggtgcgc tgctccgggt ggtctatgtc gcgctgccgc cgctgcacga tcagtggcgc
3526741 ccggtgctgt gggcgattgc catcctcacc atgacggtgg gcaccgtcac cgcggtaaac
3526801 cagaccaacg tcaagcgtat gctggcctat tcatcggtcg cgcacgtcgg tttcatactt
3526861 accggcgtga tcgccgataa tccggcgggt ctttccgcga cgttgttcta tctggtcgcc
3526921 tacagcttca gcacgatggg tgcgtttgcc atcgtgggtc tggtccgagg cgccgacggc
3526981 tcagcaggtt cagaggatgc cgacctgtcc cactgggccg ggctgggaca gcgttcacct
3527041 atcgtgggcg tgatgctgtc gatgtttctg ctggccttcg ccggcatccc gttgaccagt
3527101 ggattcgtca gcaagttcgc ggtgtttagg gccgccgctt ccgccggcgc ggtgccgctg
3527161 gtaatcgtcg gcgtgatctc cagcggcgtc gccgcctact tctacgtgcg ggtgatcgtg
3527221 agcatgttct tcaccgaaga atccggtgac acaccacacg tggcggcacc cggcgtgctg
3527281 agcaaggccg ccattgcggt atgcacggta gtcaccgtgg tgctggggat cgccccgcag
3527341 ccggtgctcg acctggccga ccaggccgcc cagttgctgc gctgaatccg ttagggctga
3527401 ccgaagaagc ccgactggtc actgccctga ttgaagcccc ccgagctgtg gtcacccgtg
3527461 ttcgccacac ccgtgttgag ggtgcccgag ttcgcaatgc ctgtggtctg caggccagag
3527521 tttgcgatgc ccacggtgcc ggcacccgag ttatagaagc cgacgttgaa gccgccggag
3527581 ttggtgttat tgatgcccga ctgaacgtca ccgttgttcc catagccagc cgaaacattg
3527641 cccgtgttaa agaagcctga ggaattcatg ccggtgttgc cgaagcccga gctcgaaacg
3527701 gattggtcga ccgagcttcc aaacccggtg ttccggtcgc ccgagtcgaa accgcccgta
3527761 ttgatgctgc ccgagttcgc gaatcccgta ttgatactgc ccgcgtttgc gaagcccacg
3527821 tttagggtgc ccgcgttgcc aaagcccaca ctttggttgc ccgcattgcc aacgcccacg
3527881 ttaaaggaac cgccgttccc gacgcccatg tcttcgttgc ccgcgttccc gatgcccata
3527941 ttgaagaagc cggcgtttcc gaagcccgtg ttggtgtcgc cggcgtttcc gaagcccgtg
3528001 ttgatgtcgc ccgcgtttcc aaagccgaag ttgttgttgc ccgaattgaa gaagcccacg
3528061 ttgttgttgc cagagttgaa gaaaccgatg ttgttgttac ccgagttccc gaaacctaga
3528121 ttcccgatgc ccgagttcag cgcgccaatg cccaccaagt tgtcgccggt gagcccaaaa
3528181 ccgatgttgt tgttgccatt gttcccgagg ccgaggttat tgtcgccgtt gtttccgaaa
3528241 ccgatgttgg aggagccgat gtttccactg cccaagttga aggaaccgag atttccgccg
3528301 ccgaagttgg tacttccggt gtttccactg cccaggttcc cactgccaaa gtttccgttg
3528361 ccgaggtttc caaagcctcg gtttccgctg cccagattga cattgccaac gtttccgctg
3528421 ccgagattgg tgttgccgat atttccgctg cccaaattcg tggcaccgtc atttccgctg
3528481 cccacattgg cgttgccgga gtttccgcta cctacgttgg cgttgccgga atttccgctg
3528541 cccagattgt agtcaccggt gttcccgccg cccaggttcc cgacgccgat gttgccgagg
3528601 ccgatcgcgg cggccagcgc cgatggcgca gctggcaacg cctgctgcag accaattgac
3528661 cacgacgaca gctgcgccgc ggccgccgat gccccgccgt gatagcccac catcgcggcc
3528721 acatcggcgg cccacatctg ttcatacatc gcctcagcgg ccgcgatcgc cggcgcattc
3528781 tgcccaaaca gattcgacaa caccaactgc acaaacgcat tacggttggc cgccaccagc
3528841 atcggatgca ccgtcgccgc ccgcgccgcc tcaaacgcac tggccaccgc cttggcctga
3528901 gccgacgcgc cagcggcccg cgccgccgca gcagccaacc accccgcata cggcgccgcc
3528961 gccgcggcca tcgccgccgc cgccgcaccc tgccaggact gacccgccaa ccccgaagtc
3529021 accgacccaa acgaggacgc cgccaccgcc aactccgcgg ccaaacgatc ccaagccacc
3529081 gatgccgcaa gcatcggcgc agaccccgca ccggtaaaca tccgcaacga attaatctcc
3529141 ggcggcaaca ccgaataatt catcagccca gccccttccc ctacaggacg tcccggccaa
3529201 tgactcaggc aacggtgcac gtctctgtac tcgtagaaca aactgtagga aaacggcgcg
3529261 acgaataacg gcgatttcgt gaaaattctg gttcccgtca gaagcacgcc accctcggcc
3529321 acctcgtttg cgcacgccta gagcccgcgg tcggggggtg cggtctggat ctccaaagca
3529381 tctgctgctg cccggatctc ggctagccga tcagggtccg acaacagcgc cgtcatcgcg
3529441 aactcgacga tctcgtccgg gctgaccgcg aattccggca gcgccagagc gtcaaacaac
3529501 gcctgcacca gcctggcagc cgataacgga tgcattgcgc gcacatcacc ttcgccttgg
3529561 ccggtctcga tcaggccaac cagcgcgcgt tccatctccg cgactagctc ccgctccgcg
3529621 acgaaggatt cctgatgcag gtccggggtg atgaggatgg aaaccagcac atagggcgaa
3529681 gcatgcaggt ggtccaggga ttccgtcagc cagcggtgca gcttgaccac cgccggaacc
3529741 ggcatcgcgg tgatgtgacc gaacagctca agcggccact ccacggcgag ccgcaccagg
3529801 gccgcaagga tatcgcgttt ggccgagaag tgtttgtaga tggccggctg ctccaccccg
3529861 acggctgcgg caatgtctcg cgtcgaggtg gagctgtaac cccgcagcgc gatgagctcg
3529921 gcagcggccc ccaggatgcg gagtgccgtt gggctccagc ggccggcctg cctcggcatg
3529981 ccggcaaggc tagctggcac ctgggtggtc gccaaccagc gccatggcga ggttccggta
3530041 gaacgcgagc atgccgggcc attctttcga gctaaggtga ccccgttcgg cgaatcgcga
3530101 gcccgcccca acctgcacgg cctccagtcc gagccggtcc tcgtcattga tcatcgccat
3530161 cacgaactgc gacgtctgag ctgttgctgc cgcatcggcg gctaactcgg gggtggtgag
3530221 cacgccgccg agcacctgca cccggtcgat gctttgcgga ataaagccga accacaccac
3530281 ccgctcgccc gctatggcca gcgcgctgtt cggaaacgtc cacaacacga ccagattact
3530341 tttctgaacc tcgttgagct gcaacgactt cgcttctact ggaacggtga agggaaccct
3530401 gaggcgcaac gcccaccgcg aatactgccg aacgtccaga tcgcccccac caggaacgaa
3530461 cggctccagg gtttggcgat gcaggccgag cacgtggtag ttctcatgac cattttccgc
3530521 cgccaccttc caattagctc gccactcatg cgaccacgac tcgacctgca ccatctcacc
3530581 gagccgatag ccggcgaatt cgtcgtcagt caggtccaga tgcgccgcga ttggttcggc
3530641 atcggcatcc aggttgatcc acaccaatcc attccaggtg gccacggcga actgcggaag
3530701 ccggcactcc ctacggttga agtctaagtt ggcggccata tggggcgctc cgcgcaaccg
3530761 gccatccagc ccatagcgcc acaggtggta ttggcaggtc aacgtgtcga tgcgccccgc
3530821 accgggttcc accatcagca tcaaccggtg ccggcagatc ggcgaaagag cgtgcagctg
3530881 cccgtcgacg tcccgcacca ccatgaccgg ctcccctgcg acggacacgg tgacgtagtc
3530941 accggtcttg gcgacttggt cgacatgcgc gacaagcatc caggaccggt tgaagatccg
3531001 ttcccgctcc agctgccaca gctccgatga ggtgtaggcg gccggcggca ggcttagcgc
3531061 cggtggattg tcgtcgaggt aatccccgat gtcggtaagg atgtctccga gctcggctcg
3531121 gttatcagtt gataacatac cctccatgtt atcgactgat aaccgattgt caacagcgcg
3531181 caccggcccg accggccagc cggcggttca cctcgagaac ggacgggtgg ccagcacgta
3531241 ggtagccaac acggccaacg gtgccgccaa cggcagccat ggcacttgca gcgggaacga
3531301 cgtcgcagcc aacccagcga acgtgaaacc aacggcggca acggtcgtcg gccagctccc
3531361 ggcgacaaca ccggccccgt atcggcacac caggtagacg gcggcgcaaa accccgacaa
3531421 tgcggcaagc acatgcgtcg ggccggacac cacgatcatc accaccgaca acaccacggc
3531481 aagcgttgcc gccaggcgaa acaccgccgc cacccctacc gcaatcaccg cggcaagccc
3531541 cacgacaaca gccagcccgt gcgatcccac agcggccgac cccaccatca tcagtccgaa
3531601 caccgtggag agcccacgag tacccgggtg cgcaaacgag gtcatggcag cctcgcccgg
3531661 ctagctctgc cccgtccgcg acgacggcga ttgggcaacg cacccatcga ctgctgaagc
3531721 gagtgatccg ccggccagga cagcacgtcg accccgatgg tggccatgtc gcgatacatc
3531781 gcggagcgct gcagcgccca catccggacc accaggggat ccagttggtc ctggagcgga
3531841 cagctatcaa gaacgtcgac agcaaccacg acgtggccgc gtttacgcag gtcgatcaac
3531901 gccagcgcga actcggtatc cagcagcgtg gaaaacgcaa tgacaaccgc tcctgcggga
3531961 acagctgcgc gcggagccag cgtcccggtg gtgttttcga acccttcccc ggcgccgagc
3532021 acggtgtcga gcacccgata gaactggcgc tgcccgatgt cggcgcccag ccatcgcggc
3532081 cgattgccgc ccagcgcaac gatcccagca cggtcaccgt ttcgcagcgc ggtttgcacc
3532141 acctgagcag caccccgcac gactcgttcg gtggcctcgg tcgccggacc cgccggctgt
3532201 cgatacatgt cgatcaacac caccacgtca gcggcccggt cggtcaaccg ccttgtcacg
3532261 tgcagtcggc cacggcgcgc gcttaccacc cagttcacgg cacgtagctg gtcgcccggg
3532321 acatatgggc gaatgtcggc gtattcgaca cccggcccga cgtgccgggt gagatgagct
3532381 cccaggcggt cgagcaattc ggtctgcggc agtggcgtcg actgcggcgg tgtcagcgga
3532441 aacacgacga tttcggcggc gtcgacggtt ccggctccca tcaacaaccc accgcgtgcg
3532501 acgacggcga cccgggcccg gataggatag cgcccccagc gttgcgccac cgcggaaacc
3532561 gttgtcgtcc ggcgtgacac ggattccaga gcttcgaact gcattcccgc caacgccgat
3532621 accgtgagtt cgaccgcggc gtccacggat tccgttgtga cccacacggt cactcgcaca
3532681 tgttcgttct cgaaacatcg ctgcgaatcc gggtcaccgt gcacctggat caccgggacc
3532741 ggacgctgcc agctgatcga gcacaacacg ccgagcagcg gcgccgcgaa cgcaatcagc
3532801 tgccaacgac cagcgacgac cgctgcggct agcgcaactc cggcacaggt ggcaatcgcc
3532861 agcgtcagtt gtgatgcacg ccagcgcaac tcgacttcac acgtttggat cacatcgcgc
3532921 cgtagttcat ccagccaacc cgctacgttc cactaattcg gggaacaggc agacgccgca
3532981 acagctctga gaccacatca gcgcccgcaa tcttgcgcac ccacatctcc gggcgcaatg
3533041 tgatccgatg cgcgacggcc gcggtcgcaa gttccttgac atcttcgggt atgacgtagt
3533101 cccggccgag caacagagcg cgggcacggg agagctggac caggtcgagt tcggctcgcg
3533161 ggctggcgcc gacggccacc tgcggatggt gccgggtagc gttggccaac gacaccacat
3533221 agtgcaagac gtcctcgtgc acggtgacct gctcgaccga ttcacgcatg gccaacagat
3533281 cgtggcagtc caccacctga ttcaccgtcg gatccgcaga accgcgttcc aggcgacggc
3533341 gcagcatcga ggtctcgtct cgctcggaga ggtagcgcag ttccaaccgg atcgcgaacc
3533401 gatccagttg cgcctccggc agtggatatg tgccctcgta ttcgatcgga ttgtcggtcg
3533461 ccagaacgat gaatggcatt gccagtttat gggtttggcc atcgatgctc acctggccct
3533521 cggccattgc ctccaacagt gccgcttgcg tcttcggcgg cgtccggttg atctcgtcgg
3533581 cgagcaacag gttggtgaaa ataggcccgg cccggaattc gaaacgaccg gactgcatgt
3533641 catagatggt cgagccgagc agatcggccg gcagcaaatc aggcgtgaat tgcactcggg
3533701 tgaaatcgag ccccaacgcg gcggcgaagg atcgcgcgat cagcgtcttg ccgaggccgg
3533761 ggagatcttc gatgagcacg tggccacggg cgagcacggc ggtgaggatg agtgtcagtg
3533821 cagagcgctt ccccaccacc acacgttcga tttcgtcgag caccgcctcg cagtgggcgg
3533881 tggtcgtcgc ggccggcata atcatcgttg agtcatacct gttctaactt ctgcagaatt
3533941 tcttccagtg ccgcacggcc ggggcctggt tgacggtcgc cggtgtgcgt cacattgttc
3534001 gggttgaccc attcccacaa ttcgtcgccg aaaagcattc ggccggtggc agcaaaggca
3534061 accgggtctt tggcctgtct atggccggtg gcgatttcga accgtcgtgc gagcatcgga
3534121 cgcaaatgcc ggtcccagtc ggctcgagtg gactccgacc accggatcgt cgtctcggtg
3534181 ttggagagcc accggcgcaa cccctccccc agatcgtcgg agtccggcgc agccgtgagt
3534241 tcgtcccggt tgcccagcat ccggcggacg ttgagcagca ccagagccag ggcgagcccc
3534301 gacccggcga gcacgagccg acggtcgtgc agtatcagcg ccagcagctc aatccccacg
3534361 atgaggaaaa tccccagggc gataagcctt ttcatatagc ggtccgagtg ctcagttcgt
3534421 caagaaccag tcgaagcaaa cgcatcgcca cctcacggtg ctcctcgttc atcacgtgcg
3534481 ggctaaaacg cgcctcggcg aacaggctca ccaacgcggc ggcactagca ccatggagcg
3534541 cacggtgttc gacggctcgg gccagcacct cggtcggggt gtcgaagtcc tgaggggcaa
3534601 caccgggaac atgcgacagt tcacgctcca tcgccacgta acacgcaatt atcgcctccc
3534661 gtggttcgcg gcggaggtcg gccatctcgg ccagtccgat ctcggcggca cgcgccagtg
3534721 attccgaacg cgccgagggc gccggagact cgatgcgatc gccactgata cgagccggtg
3534781 ccgacttgcg ctgtcgtcgc gaggtaatca gcgaccccgc gacgaccatc aagaacaggc
3534841 cgattgtgct ggcaaagaga atgccgagca cgtcgtcatt gttgtcttgc ggcggttgcg
3534901 ggcgcgacgg cgtggtgctg gaagcatccg gcgtagcggt tgaatccggt atgggcgcag
3534961 caggaccgac atcatcgggc acgaacaacc gtgccagcag tatcgcaatc agcagccagg
3535021 ccaggattgt cccgagtccg agcaacagca cacgccagtt cggacgccct gctgcaccgc
3535081 caagcattgc cgagagctcc cccgcgctgg gcgccaccgg gagcggatgt cgcaaccggg
3535141 tgatgatggc gagcgctatc agcgcgagcg tcgcggcaag tgcggcgaca atgaacatca
3535201 gcgccgcccg gctgccgccg gccgccgcga gcggtgcacc gtcgtcggcc ggcaggtggc
3535261 cgcgcagggc agcgccagca agcatcaaga gcacgatcac gacgacgacg cgccctgtcg
3535321 gtttgtcact accgggctta gtaccgggca tacgcacacc actcgaccgg ttgcctgccg
3535381 ccgttgcggc ctgggggttg gttcaacctg gcttggttca tactggcacg tcagacgaca
3535441 ctgccgccag gagcggcgcg gtggacccct cgcacgacga tcgcggtggt ttggtccacc
3535501 cacgcgtcgt ccagcatgtc gtccgggtac agcagcatcc gcagcatggt ggcgcccccg
3535561 atcagctcga tcaaccggtc cgggtccacg tcgggatgcg cctcgccgcg gtcgacggcc
3535621 tcgcgcaggc gcatgcgcac cgcggcgaat aagtcggcaa aacgcgccag cacccgggcg
3535681 ttgagttcag cgtctgcggt catatcggct accagaccgg gtaacgcggc ccgcaccacc
3535741 ggggtggtga acacatcgcg ggtggccgcg atcatcattc ggatgtcggc ggcgatatca
3535801 ccggccgcag cctgcagcgc ggtgggcgcg gcgggaaacg cggcctcgtg cactagttcg
3535861 gccttgctcg accaccgccg gtacaacgcc gatttggtgg tgccggcgcg ttcggcgacc
3535921 gcggccaagc tgaggttcga atacccgatc tgcacaagca gttccgccgt cgccgacagg
3535981 atcgccgagt cgatgcgcgg atcacgcggc cgcccggcgc cgggggcctt gtcaagggag
3536041 ggcaggtctg ctttcataac gctacctaaa gtagcgtaat tgccgcacca gggaggcgct
3536101 tgtggccaac gaaccggcaa tcggagccat cgaccgactc cagcgctcga gccgcgacgt
3536161 gaccaccctg ccggcggtga tatcgcgctg gctgtcgagc gtgttgcccg gtggggcggc
3536221 acccgaggtg accgtggaaa gtggcgtgga ctccaccggc atgtcgtcgg aaaccatcat
3536281 cttgaccgcg cggtggcaac aagacgggcg atcgatccag cagaagctgg tggcgcgggt
3536341 ggcgccggcc gccgaggacg tgccggtgtt cccgacgtat cggcttgacc accaattcga
3536401 agtgatccgg ctggtcggag agctgaccga cgttcccgtc ccgcgggtgc gctggatcga
3536461 gaccaccggc gacgtgctgg gaactccgtt ctttctgatg gactacgtcg agggcgtggt
3536521 gccgcccgac gtcatgccgt acacgttcgg tgacaactgg ttcgccgacg cgcccgccga
3536581 gcgccagcgc caactgcagg acgccaccgt cgcagcgttg gccacactac attcaatccc
3536641 taacgcccag aacacgttta gcttcctcac ccagggccgc accagcgata ccacgctgca
3536701 ccggcacttc aactgggtac ggtcctggta cgacttcgcg gtggaaggca tcggtcgatc
3536761 cccactactg gaacggactt tcgagtggct gcaaagccac tggccggacg acgctgccgc
3536821 gcgcgagccg gtgttgctgt ggggggacgc gcgggtgggc aacgtcttgt accgagactt
3536881 tcagccggtg gcggtgctgg actgggaaat ggtggcgctg ggtccacggg aactcgacgt
3536941 cgcgtggatg atatttgcgc acagggtatt tcaggagctt gccggtttgg cgacgctgcc
3537001 gggtttgccg gaggtgatgc gtgaggacga tgtgcgcgcc acctaccagg cgcttaccgg
3537061 cgtggaactt ggtgacctgc actggtttta cgtgtactcc ggggtcatgt gggcatgcgt
3537121 gttcatgcgc accggtgcgc ggcgagtgca cttcggcgag atcgagaagc ccgacgatgt
3537181 ggagtcgctg ttctatcacg ccggcttgat gaagcatctt cttggagagg agcactaatg
3537241 ccgcaaatgc taggcccact cgacgagtac ccgctacatc agcttcccca gccgatcgcc
3537301 tggccgggct cctccgaccg caacttctac gaccgctcct acttcaacgc ccacgaccgc
3537361 accgggaaca tctttctgat caccggtatc ggctactacc ctaacctggg cgtgaaagac
3537421 gcgttcgtgc tgatcaggcg tgcggacata cagaccgcgg tgcatctttc ggatgccatc
3537481 gactccgacc ggctacacca gcacgtcaac ggttaccggg tggaggtcgt cgagccgctg
3537541 cgaaaactgc gtatcgtgct cgacgaaacc gaaggtgtgg cggccgatct cacctgggag
3537601 ggcctgttcg acgtcgtcca ggaacagccg cacgtcttgc gctccggcaa ccgggtgacc
3537661 ctggatgcgc agcgcttcgc gcagctgggc acctggagcg gccgcatcgt cgtcgacggc
3537721 gaacggatcg ccgtcgatcc ggcgacctgg ctcggcagcc gggaccggtc ctggggcatc
3537781 cggccggtgg gggaaccaga accggcgggc cggcccgccg acccaccctt cgagggcatg
3537841 tggtggctgt atgtgccgtt ggccttcgac gacttcgccg tcgtgctgat catccaggaa
3537901 gaacccgacg ggttccgctc gctcaacgac tgcacccgga tctggcgtga cggccacgtc
3537961 gagcagctgg gctggccgcg ggtgcggatc cactaccgct ccggcacccg catcccgacc
3538021 ggggcgacga tcgaggcaag cacccccgac ggcgcgccgg tgcacttcga cgtggagtcc
3538081 aaactggcgg tgccgaccca tgtcggtggc ggctacgggg gtgactcgga ctggtcacat
3538141 ggcatgtgga agggcgagaa gttcgtcgag cgaagaacct acgacatgac cgatccgacg
3538201 atcatcgcgc gggccggctt cggcgtcatc gaccacgtcg gtcgcgcgct atgccgcgac
3538261 ggcgacggga atccagtgca gggctggggt ctgtttgaac acggggcgct gggccgccac
3538321 gacccatcgg ggttcgccga ctggtctacg ctggcgccct aggcgcttca ggcttacttc
3538381 ggcaccggtg aggctatccg cattcgcgag tccagggttc ctgggcgccg gccgggaaac
3538441 ggcccgaaaa cgacggcagc cggaatagcc gaccggaacc gccgaaatgc ggttgactag
3538501 agcggtgaca aacccaccgt ggactgtcga tgttgtcgtg gtgggcgcgg gcttcgccgg
3538561 gctggccgcg gcccgcgagc tgacgcgaca gggtcacgag gtgctggtgt tcgaaggccg
3538621 cgatcgggtg ggcggccgct cgttaaccgg tcgcgtggca ggggtgcccg cggatatggg
3538681 cggctcgttc atcggcccga cccaagacgc cgtgctggcg ttggccaccg agctggggat
3538741 cccgacaacc ccgacccacc gcgacggccg aaacgtcatc cagtggcggg gatcggcacg
3538801 cagctatcgt ggcaccatcc ccaagctgtc gctgaccggg ctcatcgaca tcggccggtt
3538861 gcgttggcaa ttcgagcgaa ttgcccgcgg cgttccggtg gccgccccct gggatgcgcg
3538921 gcgcgcgcgt gaactcgacg acgtgtcgct cggggagtgg ttgcgcttgg tgcgcgccac
3538981 atcgtcctcg cggaacctga tggccatcat gacccgggtg acctggggtt gtgagcccga
3539041 cgatgtctcg atgctgcacg ccgcccgcta cgtacgcgcg gccggcggcc tggaccggct
3539101 gctcgacgtc aaaaatggtg cccagcagga ccgtgtgccg ggggggacac agcagatcgc
3539161 ccaggcggcc gccgcccaac tcggcgcacg cgtcctgctc aacgccgcgg tgcgtcgcat
3539221 cgaccggcac ggagcgggtg tgacggtcac gtccgatcag ggtcaggccg aggccgggtt
3539281 cgtcatcgtc gccattccac cggcccatcg cgtggccatc gagttcgatc ccccgctgcc
3539341 gccggaatat cagcagctcg cccaccattg gccgcagggc cggctgagca aggcctacgc
3539401 ggcctattcg acgccgttct ggcgggccag cgggtattcc ggccaggcgc tgtccgatga
3539461 ggcgccggtg ttcatcacct tcgacgtcag tccgcacgcc gacgggccag gcattctgat
3539521 ggggttcgtc gatgctcgcg ggttcgactc gctacccatc gaagagcgcc gccgcgatgc
3539581 attgcgctgc tttgcgtcgc tgttcggcga cgaagcgctc gacccccttg attatgttga
3539641 ctatcgttgg ggtacagagg aattcgcgcc gggtggtccg accgcggcgg taccgccggg
3539701 gtcgtggacg aaatacggtc actggttacg tgagccggtc ggtccgattc actgggcgag
3539761 cactgagacc gcggacgaat ggaccgggta tttcgacggc gccgtcagat ccggtcagcg
3539821 tgccgccgcc gaggtcgccg ccctgctatg agctgatccg ccggtcccgg acgtgccggg
3539881 tcaccgattc ggccagcgcc cgcaggtggc tgttcacctc ttggtgccgt tccagcatcg
3539941 agcagtggcc gccgggcagt tcaacgaggc cgacgacatt gggcgcggtg cgcgcaatcc
3540001 tgcgggactg gctgatcggc gttagtcgat cacgtacgcc gccgatcacc agggttggca
3540061 ccgtcagacc atccaggttg aggtgtgccg accctacttc ctcgacgagc atcttcgcgc
3540121 agccgccgcg ccccgcggca gacgtctggg tgaacaactc atagaccagt ctcgtggcgc
3540181 tggggtccgc gtcggcggcg accgccagcg tggagatcac gtgccggctt aaggccctgg
3540241 ccgcgccggg gagtggaaac ccgccgaacg tgttgaccag gctccggccg gccagcaccc
3540301 gaaccgggga caactcgcgt ggcaccgaca gcagtttcac cttgcgcacc aggtcgccgg
3540361 tggtggtgtt gatcagcgcg acggcgtccg tgcggcggcg gactttgtgg cggtagcggt
3540421 ccgaccaggc ggcaatggta atgccgccca tcgagtgccc agcgaccacc gcacgctcgc
3540481 gcggggccaa cgtagcgtcc aacaccgaat cgaggtcggc cgcaaggtga ttgaggctgt
3540541 aggcgccacg ccgtgggaca ccgcttcgac cgtggccgcg atggtcgaag gcgatcaccc
3540601 ggtagtcgcc ggccaggtcg gcgatttggt atgcccaggc ccggatggcg cagacgaaac
3540661 cgtgcgtcag cacaatcgga tagccgtgag gcggcccgaa cacctgggtg tgtaacgggg
3540721 tgccgtccgc cgcacggacg gtcaaggtgc ggctaggcgg taggacgtct ggaatctggg
3540781 tagccccgct gcttcgagtg ggtctccgag cactcatcgc cgctccccct tcgacgcggc
3540841 cccgttgccg ccttccggat gtcgcccact ctagcgtgca gttacttacg ggtagctgga
3540901 aatcgctgaa gcataggatc acagaataat aacgtcgcgg cccctgctct cagctggttt
3540961 cgcatcgcca gccgatcagt agtcgtctca gtaatcgtcg agggcggcca cgttgcgcca
3541021 actcggccac gtcgtctccc agatccggtg aattcggccg ttgcggtagg cggcaatgag
3541081 taccacctcg atgcgggtcg gctcctcgcc aggtcgcgac gtggtgatcc acacccgccc
3541141 ggcaaccttg tctgggcctc tacccatgcg tgctcgtcgt attcgaccgc gtagctgatc
3541201 gccgtggcgt agagcttgcg gtggctatcg cggaattttg cgaagctctg gctcagcccg
3541261 tcggagtaca tcaggaagtc tgggtcgtag tagtgctcga tcagctccgc gtttttggcg
3541321 acgaccatcc gatcgaacat ttcccgaagc agcgcaacgg acattcggcg atcctaaacc
3541381 ctggccgccg gccatctcac aacgtgagcg tggacgaatc cccatccatt gcgatgacga
3541441 gttcagaccg gacgggccgt tgcctgatca atcaggacct ccgctgccgc tcgggcgtgc
3541501 gcccaggggc cggcatcgtc gagggaggtg gacagtgcgg ccgcgccctc gaacagcacg
3541561 gcgagttgat tgcccaggct gcgcggatgc gctgcgccgg cttctcgggc cagccgggcg
3541621 aggcctttga tgtagtcgcg tttgtgcgag tggacgatcc gctcgactcc gggcatctcc
3541681 ccggccgcct cgaccgccgc gttgtggaat ggacaacctc gcatccgccc atcgcccctg
3541741 tttggacgat cgaacaatgc gagcagccgc tcgcgtggtg tcgcgttgga tgccttgggc
3541801 atcttgtcgg cctcgccggc ggcttgccgg agcccgcgca ggtactcctc caccaacgcg
3541861 gacttactcg gaaagtgttg gtagagagtc cgcttggata ccgaagcctt gttcgcaatc
3541921 agttcgaccc cggtggcgtt gatgccctcg cagtagaaca gctctgcagc cgccttcaag
3541981 atacgctgac gagcgccgcg gcccccgcgc ctggggggtt ccgttgttct ggtgaccggc
3542041 ggcatagtgc tgagtatacc gacctgttta caacacccct tagcgcgtgt accgtcaaag
3542101 cacaaagtac accaatcggt ttactgtagg aggtctcatg acttcactag ccgagcggac
3542161 cgtgctcgtc accggcgcca accgcggcat gggccgcgaa tacgtcgctc agcttctcgg
3542221 tcgcaaagtg gcaaaggtct atgccgctac ccgcaacccg ctggcaatcg acgttagcga
3542281 tccgcgcgtg attccgctcc aactcgacgt caccgacgcg gtgtcggtcg ccgaggcagc
3542341 cgacttagca accgatgtcg gcattctgat caacaatgcc ggcatctccc gggcgtcctc
3542401 ggtgctcgac aaggacacat ccgcgcttcg cggcgagctg gagacgaacc tgttcggacc
3542461 gctcgcgctg gcctccgcgt tcgccgaccg catcgccgag agatccggtg ccatcgtcaa
3542521 cgtttcctcg gtactcgcct ggcttcccct tggcatgagc tatggagtgt ccaaggcggc
3542581 gatgtggagc gcgacggagt cgatgcgtat cgagctggcg ccgcgcggtg tgcaggtggt
3542641 gggcgtctac gtggggctgg tcgacaccga catgggtcga ttcgccgacg cgccgaagtc
3542701 cgatcctgcc gatgtggtcc gccaggtgct cgacggaata gaggctggca aggaggacgt
3542761 gctggccgac gagatgagcc gtcaggtgcg cgcgtcgctg aatgtccctg cgcgggaacg
3542821 tatcgcgcgg ttgatgggta actgagtccg aaagtcgata tggccatgtc cgccaaggcc
3542881 tcagacgata ttgcctggct accggcgacc gctcaactcg cggtgctcgc cgccaagaag
3542941 gtgtccagcg cggagttagt cgagctgtat ctttcccgaa tcgacacgta caacgcgtcg
3543001 ctcaacgcga tcgtcaccgt tgaccccgac gccgcccgac gcgtcgccaa gcggtccgat
3543061 gcggcacgag cccgcggcga cgaactcggc ccgttgcatg ggttgccgat caccgtcaag
3543121 gacagctatg agacggccgg catgcgcacg acctgcggtc gccgcgacct tgccgactat
3543181 gtacccaccc aggacgccga ggcggtcgcc cggttgcgcc gggccggcgc gatcatcatg
3543241 ggcaagacaa acatgcccac cggcaaccag gacgtccagg ccagcaatcc ggtcttcggc
3543301 cgcaccaaca acccatggga cgccgcgcgc acgtccggcg gctcggccgg cggcggggcg
3543361 gccgccaccg cggccgggct gaccagcttc gactacggct cggagatcgg cggctctacc
3543421 aggatcccgg ctcattactg cggtctgtac ggccacaaat cgacctggcg ctcggttcct
3543481 ctggtcgggc acattcccag cgcaccaggt aatcccgggc gatgggggca agccgacatg
3543541 gcctgcgcgg gcgtgcaggt gcgcggtgcc cgcgacatca tccccgcact ggaggcgacc
3543601 gtcgggccga tgcgggcgga cggaggattc tcgtatgcgc tcgctccgcc acgagccggc
3543661 gcgctcaaag acttccgggt cgcggtctgg gccgaggacc cgcattgccc aattgacgcc
3543721 gacgtgcgtc gggccatgga tgatgctgtc gccgcgctgc gcgccgcggg cgcacacgtc
3543781 gttgagcagc ccgccaccat cccggtcgat atggcggtgt cgcacaacat cttccagagt
3543841 ctggtgttcg gcgccttcgc tgtcgaccgg tccaccctca gcccagcctc cgccgccgcg
3543901 ctcggattac gcgcggttcg gcatcctcgg ggcgaagccg ccaacgccct gggtgcgacg
3543961 ctacagagcc accgtgcgtg gttgttcgcc gatgcggcgc gccacgaaat gcgcgaccgg
3544021 tgggccggat tcttcaacga gttcgacgtg ctgctcctgc ccgtcacgcc cacccccgcg
3544081 ccgctccacc acaacaagga ccacgaccgg ttgggccgca ccatcgacgt cgacggcgtc
3544141 tcacgatcgt actgggacca actcaaatgg aacgcgctgg ccaacatcgc cggcaccccg
3544201 gccaccacca tgcccatcac caccacagct accggactcc cgatcggcat ccaggcgatg
3544261 gggcccgcgg gcggagaccg caccaccgta gagttcgccg ccctgctcac cgaagtccta
3544321 ggcggcttcc gcgttccccc tctttaggaa cgctcgggca gggccgcaat aacctcggcg
3544381 agccgatcgg gctgctccgc tgtcgtcagg tggccgcccg caagctcggt gatttccacc
3544441 gaatccgcaa gccgctctcg ggcgagccgc agttgctctc cctcgaatgg atcctcggcg
3544501 ctgcccacca caccaaaggc gacctcatcg cccagcgccg aaatgatccg cgccaggtcc
3544561 cagcgcgctg cgtgctcgcg atgctcgtcc acgaagcccg ccgtggcggg cagcacgcgc
3544621 acgccgtcgc gccggctgat cgcgtcgtgg agctccttca tctccgctgc gcttaatggg
3544681 tatccgcgcg agaagacggg gcgcaagaat ggggcgaaca tgcgccatga gcgctggccg
3544741 atcggcgtga tcgccgcgcc gagcggcgat gtgagcagcg gcgtcgtata ccaggcgtgg
3544801 gtgtggccgt cggcaaagat gccgccgttg gcgagcaggc aagccgtgat tcgggtccgc
3544861 tgatcgtttc ccgcccgctc gcgatcgatc cgccgcgcca gcagctcaag gctgacgatg
3544921 caggagtagt cgaaggcaac gacgacggtc tgcgctatcc cctcggcgtg ccagagggct
3544981 tcgacgagat ccgcgcgctc gaaggtcgag tacgggtaat cccggggttt gtcggagtcg
3545041 ccgtggccga tgtagtccag gtagatgcgg gggaagtgga atcgcgagct caagaaagct
3545101 tccaccttcg cccaaccgta ggaaccatcc ggccagccag gcaggaacgt tcgcgtgacc
3545161 cccgtcccag cagcgcgccg tatgaacgcg cgcagcggcg aacgtgggtt gatgcccggc
3545221 cgctcagcgt cgtagcccac cctctcccca gcggagaacc actcctgtgc gctgatgagc
3545281 gcgctcgccc ggtgcgtcat cgcgcgctcg ctagccgttg gcggaggttg tcgaggtcca
3545341 tgtcggtgca tctccgcaac caaagtacac cgataagttt acgtgtcgca ttaaccgatg
3545401 tacagtgtcg gttataagta caccgatcag tatacaagga gtcggcgtgc cccagagaca
3545461 ggccggcgac atcggcgcga cataccagga cgcgcccacg aagagcatca atgtgggcgg
3545521 aacgcgtttt gtctaccggc ggctcggtgc tgatgccggc gtgccggtga tctttctgca
3545581 ccacttgggc gcggtcttag acaactggga tccacgggtc gtcgacggca tcgccgccaa
3545641 gcatccagtg gtcactttcg acaaccgcgg tgtcggcgct tcggaaggcc agacgccgga
3545701 caccgtgacc accatggccg acgatgcgat cgcctttgtc cgtgccctgg ggttcgatca
3545761 ggttgatctc cttggattct cgttgggcgg cttcgtcgcg caggtgatcg cgcagcaaga
3545821 accgcagctc gttcgcaaga tcatcctcgc gggtaccgga ccggccggtg gtgtcggcat
3545881 cggcaaggtt actttcggga cgatccgcga gagcatcaag gccacactga ctttcaggga
3545941 tcccaaggag ttgcggttct tcacgcgaac cgacagcggc aaatcggcgg cgcgacagtt
3546001 cgtgaagcgg ctcaaggaac ggaaggacaa tcgcgacaaa tcgattacag tgcgcgcgtt
3546061 ccgctcccag ctcaaggcca tccatgcatg gggcacgcaa aagccttcgg acttgacgag
3546121 catcggccat ccggtcctga tcgcaaacgg tgacgacgac acgatggtgc ccaccagcaa
3546181 ctcgttggac ctcgctgacc ggctgcccga cgccacgctg cgcatctatc ccgacgccgg
3546241 ccacggcggg atattccagc accacgcaca gtttgtggac gatgccctgc agtttctcga
3546301 gtcgtgaagc gatttcgcat gaccaccaaa gccacgccca gaccagttgg attcgccgct
3546361 cctccccacc gtttcgcggt atcggcagag cgcacccatg gatctatcac cgcaccggcg
3546421 gacgagtcgg ctgcaagttg cgactcggcg ccggattccg caaaccggtg ccgacactgc
3546481 tactcgaaca ccggagccgc aagtccggca agaacttcgt cgcaccactg ctttacatca
3546541 ccgaccgtaa caatgtcatc gtcgttgcct ctgcccttgg gcaggcagaa aacccgcagt
3546601 ggtatcgcaa cctgccgccc aatcccgaca cccacattca gatcggatcc gatcgccgcc
3546661 cggtgagagc cgtcgtggcc agctcggacg agcgggcgcg cctatggccg cgcccagtag
3546721 acgcctacgc cgacttcgat tcttgccaaa gctggaccga gcgtgggatt ccggtgatca
3546781 tcttgcggcc acgctaatag gcgtcggcct gctccgcgtg gtcgagcgat cccggtgcgg
3546841 ttacccgcta cggggtgctt tcggcaccgc gatcggctag gccaccgagg gagcagacat
3546901 cgaatacagc ggccgaatca agtcgctgga cccggcaact cccacgggtg tcgtcaccgt
3546961 cgccgcgatg actggcggcc ggaagacctt tggccaggcg acgttgaacg tccgcttccg
3547021 ctgacccggc ggcctggtga cggcggccga ggacaaagaa gagcggcttc ggctgtccgg
3547081 aacccggatc gaactcgagg agctacttca gcttccggtc gatgttgcgt acgagggcct
3547141 gttgacggac gacgtttccg aatccgttcg caaaaagctc attacgctac gagccggtcc
3547201 ctcaagaacc gcctgctcga atctgcgcaa ccccgctggc gttggggcgg acgacggtgc
3547261 tcggcgtgat gtggtgcacc aaagggacat tgccgacgga actggcgttg agccagcaac
3547321 acaccgttga tcgcatgagt gatgtccacc caaccgcggt caccgacaac ggggatccag
3547381 tcgggatcat cgctggcata aggatatcgg cctgcaccgg cattgtgtgc tcacggccat
3547441 cgctgcctgg gaccaatcac cagcccctgg aaggtcgact acagccacaa gcccgacgat
3547501 ggtcgacaga tcaagatacg tctttcgaca aaacaagatc caatggtcga caaaacagga
3547561 caaactattc gacaaatcgg gatcagatgt acgacaaaac aggagtactt tgacgttgtg
3547621 gtgcatgatg aggctggtca cgagctgatc gagcggcaca tgctcgaaca gttgcgcgag
3547681 gttgcggagt acacccgtgt cgtgctgatc aatggtccac ggcaggctgg taagacgacg
3547741 ctgctccaac aattgcacgc cgagctaggc ggatggctgc gttcgttgga tgttgacgtc
3547801 gaacgcgcgt cggcgcgagc cgatcccgag gggtacatca tgtccgcgcc gcgcccgacg
3547861 ttcttggacg aggtccagtg cgccggggat ccgttgatcc tggcgatcaa gacggcaacc
3547921 gatcgtgacc gccggcccag acagttcttc ctgtcggggt cgacccgatt cctgacggtg
3547981 ccgacgctgt cggaatcact ggccggacgg gttgcgatcc tcgacctctg gccgctgtct
3548041 gtcgctgaac gatcgggtgt ccggccggag atcattgcgc aactgttcac tgaaccccaa
3548101 gtggtcctgg gcacggagcc cgccccggtc acgcgacatg agtatctgca gctggcctgc
3548161 gcgggtggct ttccggaagt tgtgcagcgc ccggcgggtc gcgcccgcag ccggtggttc
3548221 tcggactatc tgcgcacggt gacgcagcgc gacgtgcgcg agctgaagcg gatcgagcag
3548281 acggatcgcc tgccgcggtt catgcgctac ctggccgcta tcaccgcgca ggagctgaac
3548341 gtggccgaag cggcgcgggt catcggggtc gacgcgggga cgatccgttc ggatctggcg
3548401 ttgttcgaga cggtctatct ggtacatcgc ctgcccgcct ggtcgcggaa tctgaccgcg
3548461 aagatcaaga agcggtcaaa gatccacgtc gtcgacagtg gcttcgcggc ctggttgcgc
3548521 gggcaaagcg ccgactccct ggccaggcca accgcggagg gcgcgggccc gatcatggaa
3548581 acgttcgtga tcaacgagct gatgaagcta cgtgcggcga ccgaactcga ggttgacctg
3548641 tatcactttc gcgatcgaga cggacgggag atcgactgca ttcttcagac cccagacagt
3548701 cgcgtcgtcg gtgtcgaggt caaagcctcg gcgacagtga acgtccatga tttccgacac
3548761 ttgtcattcg cgcgtgaccg actcggcgac gaattcatca ccggagttct cttctacact
3548821 ggtgcccggg ctttgccgtt cggcgaccgg ttgatggctc tacccatcaa tctcctctgg
3548881 aacggacaat ccgtctccag cctgtaggcg cataccgatc gccatatttc aagagcaggt
3548941 tggagcttct gcccccaatc atcgtgcggc aacgatgggc ggctctagcg ctagtcgacg
3549001 cgctattcaa ccagctcaca ccgagctccc gcgcggccac atacccgcga ccgtgtgatg
3549061 caagcacccc accagctccg cgcatcacgc aacgaaccgg tcaaatcgta ggcttccaaa
3549121 atctccatga tctcctcggc agacttcacg tcaccccttt tcgggagctg aacaaccgac
3549181 gcggagccgt cggccgcgga tgccctgggg cggcggtccc caaacccgat atggctaacg
3549241 tcaagcggtc ggatcacggg tcgagttggg cgggggcgac tcggcacccg gcggcatggg
3549301 ctccggtgtg caggcgtcgg tcccaaacgg cgactaccag gccggggtcg ccgactgcca
3549361 atgcgctggc cagatgaacg gcgtcggctc cgcgtaaggc atgtgctcgg gcgaggtggc
3549421 cggcgtgctg ttcaaccgtc gcggtgagtt cgactgggcg ggtggcggcc cagaagtcct
3549481 cccagtcacg ctcggcgtcg gcgagctcgg attcggttag gtcgtgattg cgggccgctg
3549541 cagcgagtgc ggcgcggact tcggggtagg ccaggcggct ggacaatgcg gcgtcgcagc
3549601 cgtcccatag agcggacgcc agcgagctcc ctgtctcggt ggtgagaagt ttgacgaagg
3549661 cgctggcgtc gaagtagacg agcggcacgg tcagcgccgc tggtcgctga cccggtcaga
3549721 caccggccgc tgcggtcggg gcctgggccg tcccgcggct acgggccgct gcgcggtcgc
3549781 cttgccaatc acgccttcgg ccgtgagacg ctccaaggtg tctgtgctgt ccagcgcagc
3549841 gagtcgtgcg atcggaatcc cacgttcggt gatgacgacc tcgccaccgg cccgagctcg
3549901 atcgagccaa tcgctgaggt gcgcgcgcaa ctcggtcacg gatacatcca cactttgaac
3549961 tgtacactca ctgaaccgtg atttgtacat atcactctgc gtgcggcaac gacgacgtga
3550021 gagattgacc tgcgcaagcc ggaggcgagg tggcaacggc cggtacaccg attcgtccgc
3550081 ggtgctggcg acgccgaaac ggtcgatgtc gtggtgactg gtcaccttcc gtccaagctg
3550141 catccgaagg tgttgcaacg gaaggtgttt gccgtccgcg ctgggccttc ggcgcagctg
3550201 gcatttgtgg tcagctgcat ggcgacggca gcgcctcggt ggtgaacgcc gggtttagct
3550261 tgcagcggcc gagcaggctg cctcgttcct gctcggtgac agttggcccg acgatgaccg
3550321 cgcaccgccg ccaccacgag atataaccta gaggttatac tggtgcggaa gcgttggccg
3550381 tgatcctgct cccgcaggtc gaacggtggt tcttcgcgct caacagggat gcgatggcct
3550441 cggtcaccgg cgccatcgac ctgctcgaaa tggaggggcc gacgttgggc cgcccggtgg
3550501 tcgacaaagt gaacgactca acgtttcaca acatgaagga gctgcgcccc gccggcacca
3550561 gcatccggat cctgttcgcc ttcgacccgg cccggcaggc gatcctgctg ctgggcggtg
3550621 acaaggcagg caactggaaa cgctggtacg acaacaacat tccaatcgct gaccagcgct
3550681 ccgagaactg gctggcgagc gagcacggag gtggatgacc atggcccgca actggcgtga
3550741 cattcgcgcc gatgccgtcg cgcagggccg cgtggatctg cagcgggccg ccgtggcacg
3550801 cgaggagatg cgcgatgccg tcctggcgca ccgcctggcc gagatccgca aggcgctagg
3550861 ccacgcacgt caggccgacg tcgcggcgct gatgggggtc tctcaggccc gtgtctccaa
3550921 gctggagagc ggcgacctgt cccacaccga actcggcacc ctgcaggcct acgttgccgc
3550981 cctgggcggg cacctgcgca tcgtcgctga gttcggcgaa aatactgtcg agctgaccgc
3551041 ctgagctaac tcacgcccac acttccggcc ggtctcgatc tcccaagccc cagcacagct
3551101 cgtgttccca atctgttccc aaccagatcc ttagctatgc gcatgttccc aaaagtgttc
3551161 ccgcccatga aaacggcccc cggagtctcc tccgagggcc atttcgccgg tagcggggac
3551221 aggattcgat gaaccgcccc ggcatgtccg gagactccag ttcttggaaa ggatggggtc
3551281 atgtcaggtg gttcatcgag gaggtacccg ccggagctgc gtgagcgggc ggtgcggatg
3551341 gtcgcagaga tccgcggtca gcacgattcg gagtgggcag cgatcagtga ggtcgcccgt
3551401 ctacttggtg ttggctgcgc ggagacggtg cgtaagtggg tgcgccaggc gcaggtcgat
3551461 gccggcgcac ggcccgggac cacgaccgaa gaatccgctg agctgaagcg cttgcggcgg
3551521 gacaacgccg aattgcgaag ggcgaacgcg attttaaaga ccgcgtcggc tttcttcgcg
3551581 gccgagctcg accggccagc acgctaatta cccggttcat cgccgatcat cagggccacc
3551641 gcgagggccc cgatggtttg cggtggggtg tcgagtcgat ctgcacacag ctgaccgagc
3551701 tgggtgtgcc gatcgcccca tcgacctact acgaccacat caaccgggag cccagccgcc
3551761 gcgagctgcg cgatggcgaa ctcaaggagc acatcagccg cgtccacgcc gccaactacg
3551821 gtgtttacgg tgcccgcaaa gtgtggctaa ccctgaaccg tgagggcatc gaggtggcca
3551881 gatgcaccgt cgaacggctg atgaccaaac tcggcctgtc cgggaccacc cgcggcaaag
3551941 cccgcaggac cacgatcgct gatccggcca cagcccgtcc cgccgatctc gtccagcgcc
3552001 gcttcggacc accagcacct aaccggctgt gggtagcaga cctcacctat gtgtcgacct
3552061 gggcagggtt cgcctacgtg gcctttgtca ccgacgccta cgctcgcagg atcctgggct
3552121 ggcgggtcgc ttccacgatg gccacctcca tggtcctcga cgcgatcgag caagccatct
3552181 ggacccgcca acaagaaggc gtactcgacc tgaaagacgt tatccaccat acggataggg
3552241 gatctcagta cacatcgatc cggttcagcg agcggctcgc cgaggcaggc atccaaccgt
3552301 cggtcggagc ggtcggaagc tcctatgaca atgcactagc cgagacgatc aacggcctat
3552361 acaagaccga gctgatcaaa cccggcaagc cctggcggtc catcgaggat gtcgagttgg
3552421 ccaccgcgcg ctgggtcgac tggttcaacc atcgccgcct ctaccagtac tgcggcgacg
3552481 tcccgccggt cgaactcgag gctgcctact acgctcaacg ccagagacca gccgccggct
3552541 gaggtctcag atcagagagt ctccggactc accggggcgg ttcacgaacc tgcgacctct
3552601 gggttatgag ctaaccagtc gcaatctctc ccatcgcggt cggtctcata cgtccagatc
3552661 agcctctatt ccgccgtcca gcctgttccg ccgcgtcgcg gttgtacgga tttgaaccgc
3552721 cccggcatgt ccggagactc cagttcttgg aaaggatggg gtcatgtcag gtggttcatc
3552781 gaggaggtac ccgccggagc tgcgtgagcg ggcggtgcgg atggtcgcag agatccgcgg
3552841 tcagcacgat tcggagtggg cagcgatcag tgaggtcgcc cgtctacttg gtgttggctg
3552901 cgcggagacg gtgcgtaagt gggtgcgcca ggcgcaggtc gatgccggcg cacggcccgg
3552961 gaccacgacc gaagaatccg ctgagctgaa gcgcttgcgg cgggacaacg ccgaattgcg
3553021 aagggcgaac gcgattttaa agaccgcgtc ggctttcttc gcggccgagc tcgaccggcc
3553081 agcacgctaa ttacccggtt catcgccgat catcagggcc accgcgaggg ccccgatggt
3553141 ttgcggtggg gtgtcgagtc gatctgcaca cagctgaccg agctgggtgt gccgatcgcc
3553201 ccatcgacct actacgacca catcaaccgg gagcccagcc gccgcgagct gcgcgatggc
3553261 gaactcaagg agcacatcag ccgcgtccac gccgccaact acggtgttta cggtgcccgc
3553321 aaagtgtggc taaccctgaa ccgtgagggc atcgaggtgg ccagatgcac cgtcgaacgg
3553381 ctgatgacca aactcggcct gtccgggacc acccgcggca aagcccgcag gaccacgatc
3553441 gctgatccgg ccacagcccg tcccgccgat ctcgtccagc gccgcttcgg accaccagca
3553501 cctaaccggc tgtgggtagc agacctcacc tatgtgtcga cctgggcagg gttcgcctac
3553561 gtggcctttg tcaccgacgc ctacgctcgc aggatcctgg gctggcgggt cgcttccacg
3553621 atggccacct ccatggtcct cgacgcgatc gagcaagcca tctggacccg ccaacaagaa
3553681 ggcgtactcg acctgaaaga cgttatccac catacggata ggggatctca gtacacatcg
3553741 atccggttca gcgagcggct cgccgaggca ggcatccaac cgtcggtcgg agcggtcgga
3553801 agctcctatg acaatgcact agccgagacg atcaacggcc tatacaagac cgagctgatc
3553861 aaacccggca agccctggcg gtccatcgag gatgtcgagt tggccaccgc gcgctgggtc
3553921 gactggttca accatcgccg cctctaccag tactgcggcg acgtcccgcc ggtcgaactc
3553981 gaggctgcct actacgctca acgccagaga ccagccgccg gctgaggtct cagatcagag
3554041 agtctccgga ctcaccgggg cggttcaatt cgtttcggcc tgttctgttc ccaaatccgt
3554101 tcccaacaca gcaatcagca gcaatcccag gccgaaatcg gtcagactct tggtggacct
3554161 acagcacctc gcctccatgt ggtcgcggag ctagtgaggg tccatcggca gcaccactta
3554221 gggcgcctcc gttgtcatca tggtcgataa gcggtagcgt ttacggtagt agaaccggaa
3554281 gttgcggagg aaccacgatg gcggtcaccc tggaccgggc ggtcgaggcc agcgagatcg
3554341 tcgatgccct gaaacccttc ggcgtcaccc aggtcgacgt cgccgcggtc atacaggtgt
3554401 ccgatcgggc ggtacgcggg tggcggaccg gcgacatccg ccctgagcgg tacgaccggc
3554461 tggcgcagct tcgtgacctc gtcctcctgc tctcggattc gcttaccccc cgaggtgtcg
3554521 gccagtggct gcacgccaaa aaccggctcc tcgacgggca gcgcccggtt gacctgctcg
3554581 ccaaggatcg ctacgaggat gtgcgaagcg cggcggagtc atttatcgac ggcgcctacg
3554641 tgtgaagctt gccgacgcga tcgccaccgc accgcggcga acgctcaaag gcacctactg
3554701 gcaccaaggc cccacacgtc accctgtgac ctcctgcgcc gaccccgccc gaggtcctgg
3554761 ccgttaccac cgaacgggcg agccgggagt ctggtacgca tcgaacaaag agcaaggtgc
3554821 atgggcggag ttgttccgcc acttcgtcga tgacggggtc gatccattcg aggtccgtcg
3554881 ccgcgtcggt cgagtggcgg tcacactcca ggtactcgac ctcacagacg agaggactcg
3554941 atcccatcta ggtgtggacg aaacagatct tctgtccgac gactacacca ccacccaggc
3555001 catcgccgcc gcccgcgatg ccaacttcga cgccgtactg gccccggcgg cggcgctccc
3555061 cggttgtcaa acacttgccg tgttcgttca cgcactgccc aacatcgagc ccgagcgatc
3555121 cgaggtccgt caaccgcctc cgcggctcgc caacctactc ccgctgatcc gtccgcacga
3555181 acacatgccc gactccgtgc gcagattgct tgcaacgctg acacgtgcag gagccgaagc
3555241 aatccggcgc cgacgacgtt aaaggcttcg agaccggacg ggctgtaggt tcctcaactg
3555301 tgtggcggat ggtctgagca cttaacgctt cgttgaccaa agccccactt gatgcgagga
3555361 cgcgatcaga caacggaatg gcctagccgc cgtcgcggtg gctttgcgcg actggggcgg
3555421 ctcacggaat ggtcgtcgtt ggcacctctg ctgtcgggcg taatgcaaag ggaatcaatg
3555481 tcaggtgaat ctcgcgttcg ggatcaccgt cggcgtgcat ggtgaactcg tactggtctg
3555541 caccggcccg atgtgcgggg cagcgcttat gattcgggtg ctctttgatc ttggcgatgg
3555601 cgttatcgat gaccgcggtc acgtctttgt tgcggataaa gagcaagatc gcggccttgg
3555661 tgtcgcgcca cacaaggtag ccgaatagct gcttcagcac atcgtccatg gttcttgggc
3555721 ccgaccacac tttgcattcg ccaatgaaga tgttgcggtc gtcgacgcga atgagaatgt
3555781 cggtcttgcc tgcgccgttg aagagttcgc ccccggcatc gccttcaaac tgtgcgttga
3555841 ggccgacgag cagcatgtct cggatttctt ccccgtcgag cttggcggcg acagatgggg
3555901 tgcgctccaa cgcgttccgc tggttacgga gcacccgaag tgcggactgg tagtcctcat
3555961 cctgcattgc aggctccggc ttgaatgctg ccctcgcgcc cgctgggcgg tgtggccgcg
3556021 gacgcacgct tttccgactg atcggagctg cgtatgtgtc ggcgtccttc ctgcggcgta
3556081 cagggaagcc gatctcggcc tggaggtttc gggtcgctaa gagctgctca cggcgcctcg
3556141 ccaccatgcc cggtagctcg ttgcgcagtc cttggttgtg caagtcgatc tgccggcgcg
3556201 accaaccgag gtacttctca atattcgcga tctgcttatg aaacgccgcg ttgatcgccg
3556261 cggcgtcatt cgacagattg tcgatcgcca ggtggatttc gtgaccttgt agccgcagta
3556321 cctgcggcgg catggtcgtg aactggtccg ggcgaaggtt aaagatgtcc ttatgcccct
3556381 cgaagggcac cacgagaacg agcctcgtca cgcgtcgggt gcgctgttcg ccccaatccc
3556441 ggtactgctg gtcgacctcg gtggctggca gcatgaaagc gtcgtcgacg cgcagatcgg
3556501 ggcattcgac cgaacccaat tcgacgagct gttcgacgac gtcatcaacg ggcgtgttca
3556561 gcaggtcgtc ggcgtcccag ctctgaagac gctgcgccgt ggcttggctc gcctttccga
3556621 gaaatccggc taaggagcca gcgagatcgt tgaggcgccc cttggaaaac agctgaacat
3556681 actccactta cccgaagata gtgctcatcc ccgacgcggc tacggaggcg tttcggcggc
3556741 gtgccgcgat gcaatgcagc cagcggagcc accgggccgt agccgacgtc gcgtcgtggg
3556801 tggcgacggg gttctccggg gtgccggaat ccttcgacga gcttgtcggg ggtcatgatt
3556861 actgttctcg atatgaacgg attcaaggat gcgaggcccg atcgtcttcc gctttcggca
3556921 tcggtttggg atatcgccca gcgatacaac aagggcggac ctaccgtcac tgaggcgcta
3556981 tacgaggcgc tgaaggaact cgaggcccaa gtcatcgctc tgcagcgaag cgagggtaag
3557041 ggcctgctca gccgcctgag ctgaacgact agaggattgg ggaaggggcc cccggggaat
3557101 ggatcatcct actgagcggg aatgggccag catcgccgaa catacacgcg cctccaactt
3557161 caccggcgac ctgttacgaa tgccgcctta cccgctgatc ctcaccctcc gaacgctggt
3557221 ggggtctgcc gaggtggtca ctgcatcaca taccctcttc ctgtcggcgg caactgaata
3557281 ctgaccagag cgcggcaagg tgggttctag tcaacgtcgc aacaattgat ggtctggtga
3557341 ggttagcagc gcggtgaaaa gttcagcggg actgcggtgc ccgaggactt ggcggggtcg
3557401 gttattgatc tcgtattcga cagcccgcag atggtcgggc gtgtaggtgc tgaggctggt
3557461 gccctttggg aagtattgcc gtagcagacc gttggagttc tcgttgctgg ctcgctgcca
3557521 cggtgagcgg gagtcgcaaa agtagaccgg cgcgcccagg tcggcggtga tgtcgatgtg
3557581 ccgggccatt tcgatgccct gatcccacgt gatggaccgg accagcgtca ccggcaagtc
3557641 gctcatggtc tcggtgatcg cgatgcgcag gcagtaagcg tcgtgggtcg gcaggtgcag
3557701 cagccgaatc agacgtgtct gtcgctcgac gagggtgcca atcgccgagc cctggttctt
3557761 accaacgatg agatctcctt cccagtggcc aggctcggag cggtcggcgg gatcgaacgg
3557821 ccgctggtga atcgacaaca tcggctgggc gaagcgcggg cggcgacggc caggacgcag
3557881 atgggcgcgg cgatgagttc gtcccgtgcg cagagggcca cggtgtggcg acttgacctg
3557941 cggcggccgg atcaatcgtg attgaggctg atagacggcc tgatagatgc tttcgtggca
3558001 caaccacatc gaccggtcat cggggtattt ccgtcgcaga tgccgggcga tctgttgcgg
3558061 gctccaccgc tgggccagca gctcggcgat cagctcacaa aggtcggggt ttttgtcgat
3558121 ccgacgccgg tgacggcgga ctcggcgttg aaccgcccag cgatgcgctt cgaacggccg
3558181 gtactggcca tcgcggcgac tgttgcggcg tagctcccgc gacaccgtcg agggtgcccg
3558241 tccgagctgg tcggcgatct tgcggatact taggcccgag cggcgcagat cggcgatgtt
3558301 gatccgctcc tcctcggaca gatagcgact actaatttgg cgcacagcca aacgatcgag
3558361 cgcgggcacg aatccgacgg cttcgccacg ccgataggtc ttgtatcccc gcgcccaatt
3558421 gtttgctgca gtccgggata ctccaacttc acgacccgct gccgagatgg accagccccg
3558481 agcccgcagc tccataaacc gttgacgctt ggccgactgt gggcgccggc ccggaccctt
3558541 tttcacgcga cgagacgatg acaacacaac ctccagaacc tagagatgtg ttgcgacacc
3558601 gcctagaaac caccttgccg acacctgatc agttttcggt tgccgctgac acaatgaaca
3558661 tggcccgctt cacccgttca gcgtcacgtg gataagcggc ccgtagcgcg tcccagtcgg
3558721 tttcggagta gtcgggccgt tgtacagggg catccggcgc ggccggtggc ggcatcttga
3558781 tgccgccacc ggccgcgtca cggttcgcgg ttggcgctcg cctgacgacg gtgctgctcc
3558841 cgttcctgag cacgctgctt tctagccttg cggtctccct gctttcccat ctcccggtcc
3558901 tcccggcggg tcacgatagc cgcgcactcc gacatacctg gcgcggcgcg gggcgctgcg
3558961 aaccggatgg gcgccaccac cgataaccat tgcgcgttgc ggcagccttc gcattagcaa
3559021 tgctggcgcg ccgctcgacg cctcggctat cacctcacct gaccaccgcg cgcatcaccg
3559081 acgagacctc atcatcgcgc ccgctctcgc aaacaccacg cccgccaaac ggggctggcc
3559141 cgagacgatt tcagaggccc ctacagaccg atccgcacgc ccgaaacccg ggttaccgct
3559201 aagcagccca ggacagcagc cgcagtcctg atcggcgaag actgacgttc agaccgcaag
3559261 caagctaaat agcaagccaa gcaattagca agactaatgt tcccaaatcc gttcccatcg
3559321 ggcatgaaaa tgaccccaga ggtcgcacct ctggggtcat ttccgctggt agcggggaca
3559381 ggattcgaac ctgcgacctc tgggttatga gcccagcgag ctaccgagct gctccacccc
3559441 gcgtcggtaa atgccaggct accgaacacg cacgaagctc gccaaatcgc gggtgccgga
3559501 gtacgaccgc ccagatcagc ggagctcggg catacagctg cgccgtacgc gtcgatgcga
3559561 tgatgattcc gcagccgctc agccagctcg gtgacctggc gcgtcgccca ggccgcaggg
3559621 ttctctgttc cccgaaaacg gccgcaccgt cgatctcaaa cgcaactgtc gcctcgccgg
3559681 ccgcgcccgg ccttgagctg tccaccggga tcgcgttggc gttcccgcgc ggtcccttcg
3559741 tcccggcagc cgcggcgtgg gagctccagg aagctaccag cgggaagttc cagctcggtc
3559801 tgggcacgca ggttcgcaag aatgtggtgc accgatacgg tatggccttc caccgtcccg
3559861 gtccgcggct gcgctacctg ctggccgtga aggcgtgctt cgccgttttc caaaccggga
3559921 caccggatca ccacggcgag ttcgacaatc ccgacttcat cactgcccaa tggagcccgg
3559981 cgcgcattga cccccccggt cccagccccg ctgggccgcg gtgaatccgt ggatgcggcg
3560041 aggtggccga cggggtgtgg ggcgaggccg ggttcgaggg gacgaccacg cggatccggg
3560101 agccgacgag cacccgtgag cagacgcaga agtccccgat ttccggtgaa atcggcgact
3560161 tctgcgtctg ctcgccgcga gcgccccgac tgactacccg gcgtcgttga acttggtgat
3560221 ggcctcatca agtcgctgca gcgccgaccc gtaggcggcg aagtcgccct tcttctgcgc
3560281 atcccgcgcc gcgccgatgg cagcctggat ctcctgcagc gcagcaactt tggccggcga
3560341 taaggtgacc gccccgacgg gaaccggggg cgccgcagtc accggcggcg gttggggtcc
3560401 actggcaggc ggcggtggat tcgcagcggg actcggtggt accgctgcct ccgtgggcgc
3560461 gatcccggta gccgtcgcac cggccccggg cccgaacaag ccggtgagcg catcccgcac
3560521 cgtggggccg tatcccacct tgtcgttgta catcatcgcc acccggatca gccgcgggta
3560581 ggacgaagca gcgtcgctgg ctcccgggga tgcatagacc ggttcgacgt agagcagtcc
3560641 gccccgggcc accgggagcg tgagcaagtt gccccagcgg atgcggtttt ggttgtcgcg
3560701 tccgatgaca ccgaggtcct gggacaccgc cggatcggtg gtgatcgcgt tgttggccaa
3560761 cttgggcccg ttgacctggc ctgggatggt caacaccgtg agattgccgt aggtcgcggg
3560821 atcggaactg gcgctgatgt aggcggccag atagtcacgc ttgaatctgt tcatcgcgct
3560881 gatcaactga tatgaggctg aattatcgtc cttagcaatg tttttcgcga cgatgtaata
3560941 cggcggctga taactgctgg cggtcggatt cgggtccagc ggcacgtccc agaaatccga
3561001 tgtggagaag aacgtcaccg gatcattgac gtggtatttg gccaacaaca tgcgctgcac
3561061 cttgaacagg tcctcgggat accgcaggtg ctcggcaagc tccggcgcaa tgtcgctctt
3561121 aggctttacc gtgccgggga agacctgcat ccaggccttg agcaccggat ccttttcgtc
3561181 ctgttggtac agcgtgaccg ttccgtcgta ggcatccaca gtggccttca ccgaattgcg
3561241 gatgtaggaa accttcttgt ccgggaccaa ccggttgaac gccacctcgt tggagtccgc
3561301 ggtcgccgag gacagcgagg tgagctcgga gtacgggtaa ttgtccaacg tggtgtagcc
3561361 gtcgacgatc cacaccagtc gcttgttgac gatcgcggga tacacagcgc tgtctgtcgt
3561421 cagccacggc gcgaccgcct ccacccgctg cgccggatcg cggttgaaca agatcttgct
3561481 gttggagcca atcacattgg agaacaaaaa gtttcgctcc gcgaacttcg cagcgaacac
3561541 gctacgggct aaccaaccac cgagcgggac tccaccgctt ccggtgtagg tgtatctctt
3561601 ggtgtcgatg ttagtttcgt agtcgtattc gcggtcgtcg ccattgcgtc caacgatcgc
3561661 atagtccgcg gacgtgttag agatcaccgg accgaagtag atccgcggct gatccagtgg
3561721 cgccggccca tcagacacca cggtgccatt ggccccgacg acgttgacca agaattcggg
3561781 gtaaccgcca ttttgattcg ggtcgttggc gataccgcgc acggtgttgg ccggtgaggc
3561841 gatgaacccg ttcccgtggg tgtacacggt atgccggttg atccagtccc gttggttgtc
3561901 gatcaaccgg tccgggttga gttcgcgggc cgcgacgacg tagtcgcgca ggttaccgtt
3561961 gcggtcgagg tagcggtcga tcgacagctg gtccgggaaa tagtagaagt tcttgccctg
3562021 ctggaactgg gtgaacgccg ggctaacgat tgtcgggtcg agtagccgga tgttcgaggt
3562081 agtcgcgcgg tcggcagcga cctgttgcgc ggtagccggg ctatcaccgc tgtaattgcg
3562141 ataggtcacc acatcagacg tcaggccata ggcttgccga gttgcggtga tacttcggct
3562201 gatatattcg ctctcttttt gcgcagcgtt gggtttgacg ctgatttgct cgacgatcaa
3562261 cggccagccg gcgccgacaa tcagcgacga cagcagcaac aacaccaggc cgatcgccgg
3562321 aatccgcaag tcccgcaggg cgatcgccga gaacactgcg gccgcgcaaa tcaacgcaat
3562381 cgccatcaga atcagcttcg ccggcaggac ggcgttgata tcggtgtacc cggcaccggt
3562441 gaacggcttg ccgccacgcg tgtgcgacag cagctcatac cgatccagcc aataagcaac
3562501 ggctttaagt aacaccagta ccccgaccag gctaaccaac tggacgcgcg ccgagcggct
3562561 cagcgcaccg gtgcgtccgg atagccgaat gccaccgaag atatagtgcg ccaccagatt
3562621 cgccacgaat gccagaaata ccgaaacgag catgtagctg agcatcagcc ggtagaacgg
3562681 caactcgaac gcgtagaagc cgaggtcccg cccgaactgc ggatccctaa ccccaaagtc
3562741 accgccgtgc aggaacagct ggatccgagc ccagtagctt tgggcgacga tgccggccag
3562801 caagccgatc gccgcgggga ttccgatgcc gactagccgc aggcgtgcca gcacgacggc
3562861 gcgataccgt gcaaccggat cgttgtcggc atccgggacg aacaccgggc gagtgcggta
3562921 ggccaaggcg agcccgccga acacgatgcc gccgaccacc accccggcaa ccaagcacac
3562981 cacgatgcgg gtagccagca tggtggtgaa cactgagcgg tagccaagct caccaaacca
3563041 cagccagtcg acgtaagcgt cgatcaaacg cgggccagcg agcagcagca cgatcacacc
3563101 cagtgcgatc atgatcagaa tccggctgcg ccgtgtcagt ttcggcatcc ttgcggcgga
3563161 ccgcattccc actagctacg ctccctgatc gttctggctg gttgagactt tctcgacggt
3563221 cataactcta cgcaccgcaa ccatccgcag cagccggcgc gagctagcag ctcggcgtcg
3563281 gcgagcccga cgtcatcgcg tgcagcgcgt ccaccgcctg gctaagcgtc tcgaccttca
3563341 ccaacttcaa accgggcggg ctgtcggaac ttgcctcgta gcagttcttc gcgggcacca
3563401 gaaacaccgt cgcgccggcc gctcgagcag cggccatctt gtgggtgatg ccaccgatct
3563461 ggcccacctt gccatcgacg gcgatcgtgc cggtgcctgc gacgaacgtc gacccaacca
3563521 ggtggccact ggtgagcttg tcgacgacgg ccagactgaa catcagtccg gccgaagggc
3563581 cgccgacgtt ggcgaggtgg aagtccacgg caaacggcgc ccacggcgcg tccaccacct
3563641 ctatgcccag gacgccttgg tcgcgatcct tattcttgcc cagcgtgatc tgcgcgatgc
3563701 cgggcggctc gttcttgcgg cggaagtcga tcgtcacctc ctggcccggt ttcgtgttct
3563761 tcaacagcgc ggtgaactgg tcgaggttgc ccaccggagt gccgtcgacg gcgtcgatgg
3563821 cgtcaccggc ctgcagcttg tccaccgatg gccctggatc catgaccgag gcgacggtga
3563881 ctgctttcgg atacttcagg taccccagag cggcgtactc agcggcggcc tcggagcgct
3563941 tgaaatcagc ggcgttgtca ttttcgatct cttcccgcga cttgcccgga gggtagacga
3564001 ggtcgcgtgg catcaactgt tcttgacccg aaagccacag ggccagggct tcacccaggg
3564061 ttagaccgtc gcgctgggag accgtcgtca tgttgaggtg acctgacgtc gggtaggtct
3564121 gggtgcccac gatctggacc acctgcttgc cgtctatctc gccgagcgtg tcgaacgttg
3564181 ggccgggtcc cagcgccaca aacggcacgg ttaccacggc gagcaacacg ccgaatacca
3564241 cgatcggcac cagcgcgacc atcaaggtca atatccgcct attcacgccg catacactag
3564301 acggacctgg ccgggctggt tcagctgcga gcgtgaccgc tgatcgcacc ttctgttccc
3564361 gcggtgagta ccggtgaggt catgggtgac ctgcctttcg gcttctcttc cggagacgac
3564421 cccccggaag atccgtctgg gcgcgataag cgcgggaagg acggtgccga ttccggatcg
3564481 ggcgccaatc cgttgggcgc gttcggcatc ggtggagaat tcaacatggc cgacctgggg
3564541 caaatcttca cccgcctagg agagatgttc ggcggcgtcg gcaccgcgat ggccgcgggc
3564601 aaaacctcag gaccggtcaa ctacgacttg gcccggcagg tcgcgtcgag ctcgatcggg
3564661 ttcatcgcgc ccatcccggc ggccacgaac tcggcgatcg ccgacgcggt gcatctggcc
3564721 gacacctggc ttgacggggc aacctcgcta cccgctggcg ccaccaaggc ggtgggttgg
3564781 agccccaccg actgggtcga caacaccttg gctacctgga aacggctgtg cgatcccatg
3564841 gcccagcaga tctccacggt ctgggcgtcg tcgctgccgg aagaggccaa gagcatggcc
3564901 ggcccgctgc tgtcgatcat gtcgcagatg ggcggcatag cgtttggttc gcaactgggc
3564961 caagcgctgg gccggctgtc ccgtgaggtg ctgacgtcta ccgacatcgg tctaccgctg
3565021 gggcccaagg gggtggccgc aatactgccc ggcgccgtcg aatcgtttgc cgccggactc
3565081 gagcaaccgc gcagcgagat tctgacgttc ctggccaccc gtgaggccgc acatcaccgc
3565141 ctgttcagcc acgttccctg gctggccagt caactgctcg gcgccgtcga ggcctacgcc
3565201 atgggcatga agatcgatat gaccggaatc gaggagctgg cccgcgatat caatccgacg
3565261 tcgctggccg atcccgccgc catggaacag ctgctgagcc agggagtatt cgagcccaag
3565321 gcaacgccgg cccagacgca ggcattggaa cgactcgaaa cactgctcgc cctgatcgaa
3565381 ggctgggtgc agaccgtggt gactgcggcg ctgggcgagc gaattccggg tgaggcagcg
3565441 ctcagcgaga cgctgcgccg acgccgagcc agtggcggcc ccgccgaaca gacctttgcg
3565501 acgttggtcg ggctggagct gcggccacgc aaactgcggg aggccggagc gctgtgggag
3565561 cgcctcaccc gggccgtcgg catggacgcc cgcgacgccg tctggcagca cccggacctg
3565621 ctgcccgcca ctgacgatct cgacgacccg gccgccttta tcgaccgtgt catcggcggc
3565681 gacaccagcg gtatcgacga agcgatcgcc gaactcgagc gggaccagca ggcccgcggc
3565741 gccgacgact ccggccacga tggcggtcct gtggataact gagcggtgtg tctgctcgca
3565801 gtgtggcacc gtctcaggtc atgcggcggg ctgcgtctgc tctgtattcg ttgaatcctg
3565861 cgatgccggt gctgctaaga cccgacggtg ccgtgcaagt gggctgggat cctcgtcggg
3565921 ctgtgctcgt ccgtccaccg cgtggattaa ccgcgacagg tttggccgcg ctgctgcggt
3565981 ccatgcgatc accgatacca atcaccgagt tgcagcgcca agccgccgag cgtggattgg
3566041 ttgacggtga cgccatggcg aaccttgtcg cgcaactggt tggcgcgggt gtagcgaccc
3566101 ccctagccaa ccccggaaac ctggattccc ggcgtcgcgc cgcgtccatc cgggtccacg
3566161 gtcgcgggcc gttgtcagac ctgctcgtcc aggcgctgcg ctgctccggt gcccggatca
3566221 ggcacagcag ccaaccacat gcggcggtga ctcccgcggg cgtggatctg gtggtgttgt
3566281 cggactatct ggtggccgat ccgcacatgg tgcgcgatct gcacaccgag agagttccgc
3566341 atcttcccgt tcgggttcgt gacggcaccg ggatggtcgg gcccctggtg gtccccggcg
3566401 tgaccagctg tctcggttgc gctgacctgc atcgcagcga ccgcgacgcc gcgtggccgg
3566461 ccatcgccgc ccaattgcgg gacaccgtcg gggtggccga ccgggccacg ttgttagcga
3566521 cggcggcgct ggcgctcagc caagtgaacc gggtgatcgc cgccgtgcgt ggacaggagg
3566581 cgacccctga gcccccgtcg gcgctgaaca ccaccttgga gttcgatctc aacgctggct
3566641 ctatcgtggc gcgacaatgg accaggcatc cgcggtgttt ttgttgacgt tacgtctaac
3566701 ccagtcgtcc ctgctccggc acgttggtcg agattgacgc ataggctctg gccaaggtgt
3566761 cgagcacgtc ctctgtcagg gtgcgctcgt tgcggtgctt gtccagcgtt tcgatgatcg
3566821 ctctgaacag ggcgtcggca gcgtcgtgct gcgttgatct tgctgacatg gtttcttgcg
3566881 gtccaccctc ctgcacattt cactgatgcg gccaacacca caacgcttgt cggcgcttgt
3566941 cgacgcttgt cgactcgggg caagctcaac cgtccgcacc caggcagttg ttaccagatc
3567001 aacaccccga ccggataacc gtcatggatg atgggagtgt gtcagatatc aaacggggcc
3567061 gcgccgcgcg caatgcgaag ctggccagca tcccggtcgg cttcgccggt cgggcggcgc
3567121 tcgggctcgg caagcgactg accggtaagt caaaagacga ggttaccgcc gagctgatgg
3567181 agaaggccgc caatcagttg tttaccgtcc tcggcgaact caagggtggc gcgatgaagg
3567241 tcggccaggc gctgtcggtg atggaggccg ccattcccga cgagttcggc gaaccctacc
3567301 gggaagcact gaccaagctg cagaaggacg ccccaccgct gcccgccagt aaggtgcacc
3567361 gggtactcga cggacagctg ggcaccaaat ggcgggagcg gttcagctcg ttcaacgaca
3567421 ccccagtggc atctgccagc atcggccagg tgcacaaagc aatctggtcg gacggccgag
3567481 aagtggccgt caagatccag tatcccggcg ccgacgaggc gctgcgcgcg gacctcaaga
3567541 ccatgcagcg catggtcggc gtgctcaaac agctctcacc cggcgccgac gtccaagggg
3567601 tggtcgacga actggttgaa cgcaccgaaa tggaactcga ctaccggctg gaggccgcca
3567661 accagcgcgc cttcgccaag gcgtaccacg accacccgcg cttccaggtg cctcacgtcg
3567721 tggcaagcgc accgaaggtg gtgatccagg agtggatcga aggtgtgccg atggcagaga
3567781 tcatccgtca cgggaccacc gagcagcgtg atctgatcgg tacgctgctc gccgagctca
3567841 ccttcgacgc accacggcgg ctggggttga tgcacggcga cgcccacccc ggtaatttca
3567901 tgctgctgcc cgacggccgg atgggcatca tcgacttcgg tgccgtggca ccgatgcccg
3567961 gcggcttccc gatagagctc gggatgacga ttcgactggc ccgcgagaag aactacgacc
3568021 tcctgttgcc gacgatggag aaggccgggt tgatccagcg aggacgacag gtgtcggttc
3568081 gcgagatcga cgagatgctg cgccaatacg tcgagcccat ccaggtcgag gtcttccact
3568141 acacccgcaa gtggttacag aaaatgaccg tcagtcagat cgaccgctcg gttgcgcaga
3568201 tcagaacggc gcgccagatg gacctgccgg ccaagctcgc gattccgatg cgggttatcg
3568261 catcggtggg cgcgatccta tgccagctgg acgcgcatgt gccgatcaag gccctgtcgg
3568321 aggagctgat cccgggtttc gccgagcccg acgcgatcgt cgtctgagcc ggctcgcgcc
3568381 ggcgggcgca ccatcgcggg ctatgcaaca gcatccttgc gcggacgtcc gcgcggacgc
3568441 ttgtgactca cgatcgagcc ttggtcgaat atctcaccac cccaaacgcc ccagggttca
3568501 gcccgctgaa gcgccgcggc caagcactgc cgcctgatcg ggcagctcac acacagtgtc
3568561 ttggctacct cgagaccggc cggggtatcg gcgaaccaca gatcgggatc accgacgtgg
3568621 cacggcaaaa ccggcaatct ttgtctgggg gtctgtctgg ggactgtcag taccgacacg
3568681 tcctgtttca cctgcttcct ggtctggtgg cggttcttcg aaagtgatcc ggaccaggga
3568741 tgctgcggtg ggcagatgtc ccgaaagttt ggccacggat cctgtgactt cgggtccgtg
3568801 gccatctggc gaaacggggc tgattacgta gcgcttacgt agagccccgc tccacggact
3568861 cgtcagtcgc ggcggcgaca cggttcttgc tatggggggt tcccgcggtt ggcaccgcgg
3568921 cagccgcgcc gacaccaaat gcgttgttgt caatcaccgc ggccgccctc ctctcgtgtc
3568981 gcgcgcggtt gccagccccc caatgccatc tccaggctgg cagcagaatg cgacctggag
3569041 gttaaccggt ggcagcagct gaccacaacc gattttctga cctgcgcgtt tgccggtaca
3569101 ggcccggttc aggtccgacc gcgaaccagc tgcagcacgt ccgatccgta ttgttccagc
3569161 ttgcgggcac cgatgccggg gatcgcgatc agcgccgcgt cgtcggtagg tagcagctcg
3569221 gcgatcgcga tcagggtgtt gtcggtgaaa acgacatagg cggggacgtt ctgttccttg
3569281 gcggtgctca gacgccagga cttgagctgc aacaacaact cctcgtcgac gtcggctgca
3569341 cacgtctcac accgccgcag catgacggcc gccgaagtgt tcagctcgtt gttacagatc
3569401 cggcagcgcg ctgcggcgcc ccggttgcgt cgggatgtgc ccggcaccgg atcggcgcgc
3569461 gtctgcggcg caatgccgtt gaggaaccgc gagggcttgc ggctctggcg cccgcccggg
3569521 gaccgtgata gcgcccagct gagcgccaaa tggactcggg cccgtgtgat tccgacgtag
3569581 agcagccgac gctcttcctc tacgggctcg ctattggggc cgtgtgccag cgcatgtgag
3569641 atgggcagcg tgccgtcagc caatccgacc aggaacaccg cgtcccattc cagtcccttg
3569701 gcggcgtgca gtgaggccag cgtgacgccc tgcaccaccg gtgggtgccg cgcctccgcc
3569761 cgccggcgta gctcggcaag caggcctggc agctgcagtg cgggacgctg cgccagctcg
3569821 tcgtcgacca gctcggccag cgcggtgagc gcttcccagc gttccctggc gcgggtgccg
3569881 accggcggtt gtgccgtcag ccccagtggt gcgagcaccg cgcgaaccac gtcggacaac
3569941 gcggcatcgg tatcacgttc ggacacacgc tgtaaggcaa gcaacgcctg cttgatttcc
3570001 tgacggttga aaaacccctc gccaccgcga acctgatagg cgatacccgc ctgggtcaac
3570061 gcctcttcat aaacctctga ctgcgcattg actcggtaga gaatggctac ctcggatggc
3570121 ggagtgcccg atgcgattaa ccgggcgatt gacgccgcca ccgtggcagc ctcggcgggc
3570181 tcgtcggaat gctcatggaa cgacgggacc ggacccggct cacgctggcc ggacaaccgt
3570241 agcttgctgc cggcaacacg gccccgggcg gcggcgatca cccggttagc caatgacacc
3570301 acctgcggag ttgaccggta atcacgctcc agccgcacca ccgcggcgtc cgggaaccgc
3570361 cgcgagaagt cgagtaggaa acgaggcgaa gccccggtaa acgagtagat ggtctggttg
3570421 gcgtcgccga cgacggtcag gtcgtcccga tcacccaacc aggccgagag cacccgctgc
3570481 tgcagggggg tgacgtcctg gtactcgtcc acgacgaaac accggtaccg gtcctggaac
3570541 tcctcggcca ccgcggcgtc gttttcaatc gcggccgcgg tgtgcagcaa caggtcgtcg
3570601 aagtcaagta aggtgacgcc gtcgccgcgg gccttgagcg cctcgtattc ggagtagaca
3570661 gccgcgattt gcgcggcgtc caacgggggg tctcggcgtg cggccgccac tgcggtcaca
3570721 tactcctcgg ggccgatcag ggacgccttg gcccactcga tctcgccggc caggtcacgc
3570781 acatcatcgg tgctggcgtg cagcctggtg cggctggcgg cgcgggccac cacggcgaac
3570841 ttgctgtcca gcagctgcca gccggtgtca gcgattacgc gcgaccagaa gtaccgcagc
3570901 tggcgatacg cggccgcgtg aaaggtcagc gcctgcacag cgccgacgcc cgaaccggtc
3570961 cgtgccgcgg cgtcgagtgc gcgcaaccgg ctgcgcattt cgcccgccgc gcgctgggtg
3571021 aatgtcacag ccagcacctg cccggcggcg acgtgaccgc tcgcgaccag cgaagcgatc
3571081 cggtgagtga tggtgcgggt cttgccggtt ccggcaccgg ccagcacgca caccggtcca
3571141 cgcggagcca gtacggcttc gcgctgctgg tcgtccagcc cggcaatcaa tgggtcgctg
3571201 gctatcgaca tgacgtccat cttggcagcg gtagatgaca gaccgggcgt gtcgccacgc
3571261 cgtggggcgt gcgacatgaa caactgccga gccgccacac cgcccgggtc gtcgccgcgc
3571321 taggttagcg tgtcatgatc accgctgcgc tcaccatcta tacgacatca tggtgtggct
3571381 attgccttcg actcaaaaca gcgctcacgg ccaaccgaat cgcttacgac gaggtcgaca
3571441 tcgaacacaa ccgtgcggcc gcggagttcg tcggctcggt caatggcggc aacagaactg
3571501 ttcccacggt gaagttcgcc gacgggtcga cgctgactaa cccgagcgcg gacgaggtca
3571561 aagcgaagct ggtaaagatc gcgggttaac gacgtggact ttcattcgca cgctgcccac
3571621 gattcgatga tcacgcgggc gatcgagatc gacccgggca gtagcagttt cgactccgac
3571681 gcactggacc aatcgccggc ggcaagcgct gcgcgcacct catcgcgggt gaaccacgcg
3571741 gcttcggcga tttcgccgtc gctgaacgag aactcctcat ccgggtcacc caaggcatga
3571801 aagccaacca ttaacgaccg cgggaacggc cactgctggc tgcccagata gcgcacatcg
3571861 cgaacggtca ggccgatttc ctcgcggatc tcccgggcga cgcagacttc gaacgactct
3571921 ccggcctcga caaagccagc caacagcgag aacatccgtt ccggccacgc cgcctggcga
3571981 gccaacacgg cacgatcagc gccgtcgtga accaggcaga tcaccgccgg gtcgatacgg
3572041 gggaactcct catgaccggt gatcgggttg acccgtgacc agccggccct ggccggtttc
3572101 gtcggcgcgc cgtctagggc gctgaatcgt gcgttgtcat gccagttcaa cagcgccgat
3572161 gccgacgaca ccagttggct gctggtgtcg tccatgattc ggccgagccc acgaaggtcc
3572221 accgcctcgg ctggtatgtc gggatcagcg atcggctgca gcgctgcccg caccgcccag
3572281 acgtggcggc cgccctcgac gcgacccagg aataccgcct ctggcggtgg cttgtcggcc
3572341 agctcgatgg ccgcgccaag caacacccgg ccgttggcga ccagcacgcg attgcgggaa
3572401 tccacccgca gcaatgccgc gcctggccat cccgcggcgg ccgcctccat gtcggtcctc
3572461 agccggtcgg cccggtcggc gccgacgcgc gaaagcaacg gaacgcttct cagctgaaaa
3572521 tccacgccgc ttacgttcgt cactggcgcc ccacctggtg gcgacccgcc gcgcccggct
3572581 ccgccgcgct tgcgatcgcc actagcgccc cacctggcga atatagagca gccggtcgct
3572641 ggcctcgatg gcgtccacct cgggcgcccc aatgcgcagc agctggccgt cacgtaccac
3572701 gccgagcacg atgtcgcgca ggtgccgcgg agacccgccc acctcggcct gctccacctc
3572761 acgttcggca acggccaggc cggcttccgg ggtcagcaga tcctcgatca tctccacgac
3572821 gctgggcgtc gtggtagcga tgccgagcag ccgcccggcg gtctcggagg agaccaccac
3572881 cgtgtccgca cccgactgcc gcaacaagtg ctggttttcg gcctcccgga tggacgccac
3572941 gatcttggct ttgggcgcaa tctcgcgcgc cgtcaacgtg acgagcacag cggtgtcgtc
3573001 gcgactggtg gcgacgatga tcgaagacgc atgctgagtg ccggccaacc tcagcacgtc
3573061 ggacttggtg gcatcaccat gcacggtgac cagaccggct gccgcggcac gttcgaggac
3573121 acccgaatcg gtgtcgacga ccacaatttc acccggaact aactcgtcac tgaccatcgc
3573181 ggccaccgcc gttttgccct tggtgccgta gccgatgacg acggtatggt tgcgcactct
3573241 gctcctccaa cgctggatct tgtacgcctg acgggatgtt tccgtgagga cttcgagagt
3573301 cgtgccgacc aacaagatca agaacgcaat ccgcagcggt gtgatgacga agatgttgat
3573361 cgctcgcgcg aattcggaaa tgggcgtgat gtcgccgtag ccggtcgtcg acagcgtcac
3573421 cgcagcgtag tagaggcaat ccagaaacgt cagccgatcg ccctgggcgt cgaggtagcc
3573481 gtcgcggtcg acgtagacga tcccggcggt gagcagcaac gccaccacag cgacgaccac
3573541 ccggcgtgaa ataacgcgag ctggactggc ccgcctttgg ggaatgcgca gcacgccgac
3573601 aagcgcgtaa ccaggctgcg cggtcagctt ctcgttgagc ccccgcaacc gccgccagct
3573661 accggccacc gaaatccgtc accggttagc cccaatgcac gccaaacgca cgacacaaat
3573721 ggtaaccacg tcaggtgtcc gaccgccgac cggcgcagtc ggtcagtagc atggccaact
3573781 cgccgggagc gggtaactcg tcggggacga ccgtgatgcc gctgcgcacg taatagaagg
3573841 cggtacgcac cgaggatgtc ggacatcccc gcaatgcggc ccaggccagt cgatagacag
3573901 cgagctggac agcggcctgc cgcatggctg ccggcccgtg cggcggcttg ccggtcttcc
3573961 agtccaccac ggtggcaccg ccgtcggggt cgacgaacac cgcgtcgatg cggccgcgca
3574021 ccacggtatc gccgatcggc atttcgaacg gcacttcgac cgccgccggg gtgcgagccg
3574081 cccacgatga tgcggtgaac gccctctgca acgcggccaa ctcctcagga tcgcccacct
3574141 cgcggtccgc tgcacctggc aggtcaccca ggtcaaacag cagttcagca ccgtaaaatt
3574201 gctgaaccca ggcgtgaaat gcatcgccca accacgcgtg cgggtccggg cgttttggca
3574261 gccgacacat cagccgctgc cgcgcaccga ccgggtcgcc gaccagctcc accaaactgc
3574321 tgaccgacaa atggttcggc agaccacggg caggtgctcc ccgcgccgcg tgcgcacgtt
3574381 cagccaacag tgcatcgacg tcagtggacc agggggcatc gcccgggcgc gggggatgat
3574441 cgatgtcggt ggtgcttccg ggcaagtcgg ccgacatggc cgccgccacc agcgccgcgc
3574501 cccgctccac atcgccgcga cgtgcggcca acggatcagc gggccaaacc gcctcgatag
3574561 cgttgtcaca caatgggttt cgctcatcgc cggcgggcgc cgacgcccac tgctcgacga
3574621 ctccgcaagg atcaccggca gcggccgaac ggtcaatgat gtccttgagt tcgcacagga
3574681 attccgatgg cccgcgcggc tttgtcccgg tgggccccca atggtggccg gacaccagca
3574741 gagtgtcctc agcccgggta acggccacgt acaacagtcg acgctcctcg tcaacgcgcc
3574801 gccgatcgag caggcgacga tgttcggaga tcttgtccga caactgtttt cggtcagcga
3574861 cagctgacgt gtccagtacg gggatgccgt gcgcgccggc cgaggcgcga tccccacgca
3574921 gcagcggcgg tagttcggcg gggtcggtaa gccagctgct gcgcgacacc gtcgacggaa
3574981 acactccgcg cgacaggtgt gccaccgcca ccacctgcca ttccaagccc ttggcggcgt
3575041 gcacggtcag cacctggacc cggtcgcagg cgacggtcaa ctcggcaggc ggcaaaccgt
3575101 tctcgaccac ctcggcgacg tccaaataag ccagcaggcc cgcaaccgac gcctcgctgg
3575161 acctagcgct ggcccgttcg gcgtaccccg cgaccacgtc ggcgaacgca tcaaggtgct
3575221 cgggtccggc ccagccacct gagaccgggg ccgaggcccg cacctcgcaa tcgacgccaa
3575281 gcacgcggcg cacctcggct actaggtcgg gcagggaatg accgaggcga ccgcgcagcg
3575341 cgctcagttc accggccaag gcgccgatgc gcccatatcc cgccaccgaa tacccctcgg
3575401 cggaacctgg atcgctgatg gcgtcggcca gacacggatt gtcggcgtcc gcgctggccg
3575461 ccatcgcgat cgattcgggc gacgccgttg acggtgattc gccactcagc gtcagcgcac
3575521 gccgccacag cgcggcgagg tcccgggcgc cgagccgcca ccgtgggcca gtcagcaccc
3575581 gcatcgcggc cgccccggcc gttgggtcgg caaccaggcg cagcatggcc accacctcgg
3575641 cgacctcggg gatggacagt aggccggcca gcccgacaac ttcagccggg attccgcggg
3575701 cccgcagggt atcagcgata gcggcggcgt cggcgttgcg gcgtaccagc accgccgcgg
3575761 tgggcggctt gacaccgtcc gcttctgccc gctggtaacg catccgcaag tggtcggcga
3575821 tccattcgcg ttcggcctgc acgtcgggaa gcaacgcgca gcggacggct ccaggcgggg
3575881 catccggacg cggccgcaac gcgcgcaccg caaccgagcg ccgccgcgcc tccgccgata
3575941 tgccattggc cacgcgcagc gcttgcggcg ggttgcgcca gctggtcagc agctccagca
3576001 ccggcgcggg ggtgccgtcc gataagggga agtcggtggt gaaccggggc aggttcgtcg
3576061 ccgaagcgcc gcgccacccg tagatcgact gaatcgggtc accgacagcc gtcagcgcca
3576121 acccgtcatc aacgccgccg ccaaacagcg acgacaacac aacgcgctgc gcgtgccccg
3576181 tgtcctggta ttcgtccagt aacaccaccc ggtagcgcct ccgcagatcc tggccaactt
3576241 ggggagaggt cgccgccaac cgtgcggccg aggccatctg catggcgaaa tccatcactt
3576301 tgccggcgtg catccgctca cccaacgcgt caagcaacgg caccaactcc gcgcgctggg
3576361 tctgggtggc cagcatccgc agcagccact ggctggggcc gcggtcacgc tgatagcggc
3576421 ccgccggcag agcgtggacc agccgttcca gctcgacgtg ggtgtcgcga agcgcgcggg
3576481 tgtcgaccag atgctcgcca agctggcccc ataaccgcac cacgatcgag gtgaccgccg
3576541 ccgggctctt gtcggtgcac agcacgccgt cgtacccgct gaccacatcg aatgccagct
3576601 gccacagctc ggtctcgctc agcaacctgg tatcgggttc cagcggtagc agcaggccgt
3576661 agtcgcgtag tagcgagccg gcaaaggcgt ggtaggtgct gactaccgga gcgcaggccg
3576721 ccgggtcgcc gcagccgagg ccgataccgg ccaacctggc cagacgggac cgaacgcggc
3576781 gcaacagctg gcccgcggcc ttgcgggtga acgtcaatcc cagcacctgg ccgggttccg
3576841 cgtagccgtt ggcaaccagc cacaccaccc gggcagccat cgtttcggtt tttccggcgc
3576901 cggctcccgc gatgacgacc agcgggccgg gaggtgcggc gattaccgcg gcctgctcag
3576961 cggtgggcgg gaaaagtcct agcgcgcagg ctagttcagc tggactgtag cgtgccggtg
3577021 ccgcggtttg ggtcatggcg ccgaccctcg gacgtgggcc ggacagcccg gccgcagcgg
3577081 gcagtgggtg cacccgtcgt tgcgccgagc gatgaactgg ggaccggctg tcgccgcggc
3577141 cagctgccgg acgaggttgc gccattcgtc gcgcgcggcc ggtgtgagtg gatcctgttt
3577201 gcgttcggcg acgccagcgg ccccgctttt gccgacatag accagccggg caccgccggg
3577261 ctcgtccccg gcgcgcacca agccttcggc caccgccagc tgatacatcg ccagctgggc
3577321 gtgctgctgg gcatcgtcct tgctgaccgg tgtcttgccg gttttgatgt cgacgatcac
3577381 caggcggccg gccgggtcgc gttccagccg atccgcccgg ccacgcaacc gaatttttct
3577441 ggcttgaccg ctaccgtcct cgagggcccc atcgatgtcg acctccacgc caacttcggt
3577501 cagctcggat cgactctgag ctcgccactg tacgaacgcc tggatcatcg cgcggtgccg
3577561 ggcaagctcg ttggccgaat accactgagc gccgaacggc agatggcccc acacccggtc
3577621 cagttcagcc agcagttggg attcgctcct gcccggctcg gcaaacagtg cgtgcaacac
3577681 cgatccgacg gcagacggca gctcgcgggt gtttgttccg ccgtgccgct cggccagcca
3577741 gcgcagtggg cagtcgttga gtgcctgcaa agtcgacggc gtcaacgtga cgagatcgtc
3577801 gctatcgcac aacggatcac tcgtgctgac cggggccagg ccatgccact cggacgggtc
3577861 ggcacctggc acaccggctt tggccaaccg ggccaattgc gttgccgcac aatcgcgatc
3577921 ggcgtcatct accgcgcagg caggcgcgca caccacaacg cgtaaccggc ctaccaccgc
3577981 cgcagccgac aacacgcgcg gcgccgagac cggctgcatc gcgacgggtt cgccatcgcc
3578041 gtcggcccac tgggcaatct cgaaaaagaa cgccgatggc agcaccgcct cgtgcccgcc
3578101 cccgcccgcg tcgctatcta cggcggtcac cagcaaccgc cgccgggccc gccccatcgc
3578161 ggtcaccagc agccggcgct cctcggccag caacggcgcg cgcatcgagg catccttcgt
3578221 gacaccgtcg agttcgtcca gcagccgctg ggtgccaagc acaccgccac gtggaaccgt
3578281 gttgggccac aagccgtcct gtaggccggc gataactacc agatcccatt cgtgtcccag
3578341 cgcggcatgt gcgctaagga ccatgacctg ctctgtcggg gctgccggtt cgggtcgcac
3578401 aaccggcagc tgcagcgcgg tgacgtgctc gacgagtccg cgcagggacg cacccgaggt
3578461 gcgggacacg taatggtcgg tgatgtcgaa caaggcggtc accgtttcca ggtcccgggt
3578521 ggcctggaca gccgccgcac caccatgctc gctggccgcc agccagcggc gttgcagacc
3578581 cgaccgttgc caggcagccc atagcgtgtg gcgcggatcc tggccaccca gacttcctga
3578641 gcggtggcag cgcgcggccg cggtcagcac ggcacgcacg cgccgcagtg cccgcgaccc
3578701 tggccccgat ggcggcgcgt cgccgccgag cacttccacc agcaggtcgc cgaacttcct
3578761 cgaagtctgg ccgggacgtg cgcgttgcag agtccggcgc agctggcgaa gtgataccgg
3578821 gtccacacca ccaatcggcc cggtgagcag gagcagcgcc tggtcgccgt cgagcccgtc
3578881 agccgtcgcc tcgagcaccg tgagcagcgc ccgtaccgcc ggctccgcgg acaacggccc
3578941 gccaactgca ggtggggcca ccggcacccc ggcggcggcc agagcgcgcg gcaaccgcac
3579001 agcgcgcggc accgacctga cgatcaccgc catctgcgac caaggcaccc catcgatcag
3579061 gtgcgcgcgt cgcagcgcgt cggcaatcat cgctgcctca gcgtgcgccg aaccggccag
3579121 gcgcaccgtc accgatccga cctcggtccc ggtgccctcg attcgccgac cgacgcttcg
3579181 acccggtagc cgtcgtgcga tgccggtgac ggcccgcgcc acggcgggtg cacaccgatg
3579241 agagaccgtc aacgtcaccg acggaatggg ggcaccacct gctggcggcg gatcgtcggc
3579301 cagcaggccg gtgggctcgc cgccgcggaa cccgaacacc gcttggttcg gatcaccggc
3579361 gatcagggcc agctcggtgc ccgccgccag catccggacc aggcgtgccg cctgcggatc
3579421 aagttgttgg gcgtcgtcga ccaaaagggt ccggacccgg gcgcgttcgg cggccagtaa
3579481 ctcaggatcg accgcgaagg cctccaaagc tgcccccacc agttcggcgg cactcagcgc
3579541 cggcgccgtg gcctgcggcg ccgccagccc caccgcaccc cgcaacaaca tcacctgctc
3579601 gtaccgctgg gcgaattgac cggcggcgat ccattccgga cggccgcggc gacggcccag
3579661 ttgctgcaac tccagcgggt ccaggccgcg ttcggcgcaa cgtgccaaca ggtttcgcag
3579721 ctcggtggcg aagccggcgg tagtcagcgc gggccgcaga tgcgcaggcc aggtggtggt
3579781 ggcggccggt ccgtcttcgg cgtccccggc cagcagttcc cgaatgatgg cgtcctgctc
3579841 ggcgctggta agcagccgcg gcaaggcgtc accggcgcgc tgtgcggcct tgcgcaagac
3579901 cgcataggcg tagctgtgca cggtgcgtac caccggttcg cggatcgccg cccggcaagg
3579961 gccgttggtg cgcgaccgca gcagcgccgt cgtcagcgca ctgcgggccc gcatgcccat
3580021 tcggccggaa ccggtcagca gcagaaccga ctccgggtcg gtgccggcgc cgatgtgagc
3580081 gaccgcggcc tcaaccaaca gtgtgctctt accggtgccc gggccgccca gcacaagcac
3580141 cggaccgcgc aaacccggcg cgagggccgc acccgcctcg acaccccaga tatgtgacat
3580201 agccgcatga catcacgagg gtctgacaag ctcggatact ggagctggca agaaaaccga
3580261 aaacgcgatg tgaggggtgg ctaccatggc ggcggtcgta ggcggcggtc cacaggacga
3580321 aatacccgaa gccgatgcgg tggagcaagg gcgtgctgtc gatttcgacg acgaagccgg
3580381 gttggacacc gcctacctca gcggcggcgc cggcgaccga gacgccagcg aagccgacgt
3580441 cgtcgaccaa gccttcgtcg ttccggtcgc cgacgacgaa gaaatcgacc ggtagcaggc
3580501 gtcgccgggc tggcatcatc gacgcgtgat catcgacctt cacgtacagc gctacggccc
3580561 gtcagggccc gcgcgggtgc tgaccatcca cggagtgacc gagcacgggc gcatctggca
3580621 ccggttagcc catcactttg cccgaaatcc ccatcgccgc acccgatctg ctgggccacg
3580681 gtaggtcacc atgggccgcg ccgtggacca tcgacgccaa cgtgtccgcc ctggcagcac
3580741 tcctcgacaa tcagggcgac ggtccggtag tggtggtcgg acactccttc ggcggcgctg
3580801 tcgctatgca cctggccgcg gcccgcccag accaggtcgc ggcgctggtg ttgctcgacc
3580861 cggcggtcgc tctggacggg tcccgggtac gcgaggtggt cgacgccatg ctggcctctc
3580921 ccgactacct ggaccccgcc gaggcccggg ccgagaaggc gaccggtgcc tgggcggacg
3580981 tggacccccc agtgctcgac gccgaactcg acgagcacct cgtcgcattg cccaacggtc
3581041 ggtacggttg gcgtatcagc ctgccggcga tggtgtgcta ctggagcgaa ctggcccgcg
3581101 acatcgtgct gccgccggtg ggaacggcaa ccacgctggt tcgggcggtc cgtgcgtcac
3581161 cggcgtacgt cagcgaccag ctgctcgcgg ccctggacaa acggctagga gccgattttg
3581221 agctactaga cttcgactgc gggcacatgg tgccccaagc caagcccact gaggtcgcgg
3581281 cggtgatccg cagtcgactg ggaccgcgct agccatggcg ccggtgaccg acgaacaggt
3581341 ggagctggtg cgctcactgg tcgcggccat cccactcggc cgggtgtcca cctacggcga
3581401 catcgcagct ctcacagggc tttccagtcc gcgtattgtc ggctggatta tgcggaccga
3581461 ttcctcggat ctgccctggc accgggtgat cagagcctcc gggcgcccag cacagcacct
3581521 ggccacccgg cagttggagt tgttgcgcgc agagggcgtt ctcagtgttg acggccgggt
3581581 ggcgctgagc gagatccgct atgagtttcc gccgggctga gtaggtttag agcactagcc
3581641 gcactagggc cgcggtgtgg gccaggccgg gaaacgcttc ggcggtggat cgtgggtgca
3581701 gcgcgtacac tgctaggcgg aacatcaacg cgcgcaacaa catctggggc cactccggca
3581761 gcgcgttcca ccgctcgatg agcccgtcgt cggccgcacc ccaggacagc gcgtcgacga
3581821 cggccacccc ggccgcccag gatgcgggcc gccagtaggg cgtgatgtcg gtgatccctg
3581881 gaggggcggt gcccgcgaaa agcactgtac cgtaaagatc tccgtgcacc agctggttcg
3581941 ggctcttggt cggcttacgc aacccggcaa gctgattgat cagatcgatc gatcgctggg
3582001 ggtccgctgc cgggggggcg gtcggcacgc ccggtgggac cgactgtaat ggccgctcct
3582061 cccacccagc tcggtctgcg gcgacgaaca catcgatctc ggcccagggc gccgcgggtc
3582121 cctgggtcaa gaatcggggg cgttccagtt ttccggtggc ctcatgcagc cgcaccgccg
3582181 ccgagacgac ctcatcatgc ctaggctccg gcgcgccggc gacgaacgtg tctgcccgcc
3582241 aaccagacac cacgtaccgg ccgtcggtcg atcggacggg ccgagccagg cgtacgccgt
3582301 cgacgaacaa cgtctcgcgc acccgggccg accaggccgc gcgggcgttg tcggccacca
3582361 tcgacaacac cacctcgccg catcgccagc caccttccca accggcaccc aacaggatgg
3582421 gttgcgcacc tgccaaaccg aacgccacca acacgtgctc gggcggcggc tcgacattca
3582481 caccggtcag cctagtagag cccatcgggg tgtattgggc ctgtatcggt cctagtacat
3582541 caccatgtcg ggctgcatct gcttggccca cgcgacgatc ccaccctgca ggtgtaccgc
3582601 gtcggagaaa ccggctttct tgaccgcagc caatgcctcg gccgagcgca cgcccgtctt
3582661 gcagtacagc acggcggtgc ggtcctgggg gagcttggcc agaccctcac ccgagttgat
3582721 caacgatttc ggaatcagtt gggctccgtc gatatgcacg atgtcccact ccacgggatc
3582781 gcgaacgtcg atcagtgcca gcttacggcc ggagtccagc cagtcgcgca gctcgcgcgg
3582841 cgtgatggtg gaacctttgg ccgcctgggc ggcatcgtca gcaaccacgc cgcagaactg
3582901 ttcgtagtcg accagctcgg tgatcttcgg tgtcgatggg tccttgcgga tggtgatcgt
3582961 gcgatagctc atctccagcg cgtcgtacac cagcaaccgg ccaagcagtg tttcacctat
3583021 cccggtgatc agcttgatcg cctcagtgcc catcaccgat gcgaccgagg cacagataat
3583081 gcccagcacc ccgccttcag cacaggacgg caccatgccc ggcggcggcg gctcgggata
3583141 caggtcgcgg tagttgacac ccaacccgtc gggggcgtcc tcccaaaaca ccgatgcctg
3583201 gccctcgaag cggtaaatcg acccccacac gtacggcttg ccagccagca ccgcggcgtc
3583261 gttgaccaga taccgggtgg cgaagttgtc ggtgccatcc aagatcaggt cgtactgctt
3583321 gaacaggtcg acggcgttgc tcggcgcaag ccgcagctcg tgtagtcgca cccggatcag
3583381 cgggttgatc gcgacaatcg aatcgcgcgc cgactgagcc ttggagcgcc cgacgtcagc
3583441 taccccatgg atgacctggc gctgcaggtt cgactcgtca accacatcga agtcgacgat
3583501 gccgatggtg ccgacgccgg cggcggccag atacaataac gtgggcgctc cgagcccgcc
3583561 ggcgccgatc accagtactc gcgcgttctt gagcctcttc tgcccgtcaa cacccaggtc
3583621 aggaatgatg agatggcggc tgtagcgagc tacctcttca cggctgagcg cggatgctgg
3583681 ctcaactagt ggcggcaagg atgtcgacac cgaatatctc ctcggttata tccgaaacgt
3583741 ctgctgcgcg tcgtcctgca aatacctcaa cgcccagctt gccacctttg cttccccggg
3583801 ttagggaatc gggtagggcc agggattgaa tcggcaggtc tttccatccg ccttaacgaa
3583861 gtcggggtca aacttggccg cgtcgtcatt ggaggtggaa aacgtctgct gcatcattac
3583921 cggagccaga ccgccttgtt ggtcgcacgg ctcgtggcgc aggtaaccga tggcatgacc
3583981 gacctcgtgg ttgatcacat attgccgata ggaacctacg tcaccttcga atggaacggc
3584041 tccgcgtacc cagcgcgcct cgttgatgaa cacccgcgat tggcgatcca tgccgccgaa
3584101 cgacgggttg tagcaggacg tctcgagccg gaattcgtag ccacaccccc cgcgcactgt
3584161 cgtcggcgac accagcgaaa tccggaagtc gggttttccg ctgtcgatcc gcacgaacgc
3584221 gaattgcgga ttgtgggtcc agcccttggg attggtcaac gtctggtcga ccatctgggc
3584281 gaatgcgttg tcaccgccgt acattgtggg atcaagaccg ttctcgatct cgacggtata
3584341 cctgaacact ttgacggtgc cttgaccgac ctggggagta gtgcccggaa cgacacgcca
3584401 ggtcttgtca ccagcctcgg tgaacgggcc gccatccggc agcgtcccgg ccggcagatt
3584461 ggcatcgaac actgcaagac cgcgaggcgg tgcgtcgagg atcgcggtcc ccaccacacc
3584521 aatggccggc gagtcccgga cggtctgggc cgccgcgggc cttggcgtgc tcgtcccggt
3584581 caccgtctgg tacaccacca ccgtggtcag caccatcaga accggcaggg cgtaggcgcg
3584641 ccagccgtac gtggacacga accgccccaa ccaggtttgt ttgcgccatt gacgcttccg
3584701 gtcgcggcgg gcccggaccc gtctgtcagt cgcggcgagc gggtcgcgca gggcccgcag
3584761 cggctcacgc cactcgtcac gcagcacggg tactcgactc gtgcttccgg cgggccacgg
3584821 agacgtcatt tcctcaggat gacacagctg gcccgggtcg cgaccctggc gcgcccgaat
3584881 gcaacaccca acaaactatc ccgccgctac cgatgccgca ggtagtaatg tcattccgac
3584941 agacgcgcgg cggtgggggt tggcacagtg gccctcgaat tagtgtgatc agattgagga
3585001 ctgatgagcg atctcgccaa gacagcgcag cgacgtgccc tcagatcgtc cggcagcgct
3585061 cggccagacg aagacgttcc ggccccgaac cggcgcggca accgactgcc tcgcgacgag
3585121 cgccgcggcc aattgcttgt cgttgccagt gacgtcttcg tcgatcgggg ttaccacgcg
3585181 gccggtatgg acgagatcgc ggatcgggcg ggagtcagta aacccgttct gtatcaacat
3585241 ttttcgagca agttagaact ttacctggct gtgcttcatc ggcacgtgga aaacctggtg
3585301 tccggcgtgc atcaggcgct gagcacgact accgacaacc ggcagcggtt gcacgtggcc
3585361 gtccaggcgt tcttcgactt catcgagcac gacagccagg gttaccggct gatcttcgag
3585421 aacgacttcg tcaccgagcc cgaggtcgcc gcacaggtgc gggtggccac cgaatcgtgc
3585481 atcgacgcag tgttcgcgct gatcagcgcc gattccggac tggacccgca ccgcgcccgg
3585541 atgatcgcgg tgggcttggt cggaatgagc gtcgactgcg ccagatactg gctggacgcc
3585601 gacaagccga tttccaagtc cgacgccgtc gagggcaccg tgcagttcgc ctggggcggg
3585661 ttgtcccacg tcccgcttac ccgctcgtag caacctttcc ggcggaccca gctgcggcgt
3585721 ccaccccgac gccgaagccc acccggcggg cgtctgcgac accgatctcg acataggcga
3585781 tcctggcggt gtgaattagg aagcgacggc cccgctcgtc ggtcagggtc agcaaaccag
3585841 agtcgtcgcg cagcgcgttg ctgacgagtt cttctacctc actgggcgtc tgcgcactgg
3585901 agaacaccag ctcgcgcgga ctgtccgtga taccgatctt gacctccacg gtggcccctt
3585961 ccattggcat tccgtcacag gcgtgtcacc agcaggctag tagacgcccc tggcccccat
3586021 aacggttagg tctaggccag cccgacacgc cgccagacac cccatccgcc ggcaggggct
3586081 cgataacatc agcaccatcg gtaacacagt taacgacctc tacgagtgcg ttcggaacgt
3586141 ccgggaagtc caggactacc cggacgacga gagctcgagc ggcttcgggg ctggccggac
3586201 ctgttcggaa ggcgagtttg cctgggcggc tgaccgccga tggcgcccgg tagctgcgat
3586261 cctcggcagt gtggtggcgc ttggcgcggt cgcgaccgca gtcattatca acagcggaga
3586321 tagcacgtcg accaaggcca ttgtcggggc accagccccg cgcacggtga tatccacctc
3586381 gccacgacca acggccccga ccagcacgtc accccaccct tcgcccagca ccttgcggcc
3586441 gcagctcccg ccggagacgg tcaccacggt ggcaccgccg ggcaccgggc ctactaccgt
3586501 gccgacgcga acccccaccg ccgcgccacc tcagactgct gtgccaccgc cggcgccgct
3586561 gaatccgcgc accgtcgtct accgcgtgac cggcaccaag cagctgttcg acctggtgaa
3586621 cgtcgtctac accgatgcgc ggggcttccc ggtgaccgac ttcaacgtgt cgctgccgtg
3586681 gacgaagatg gtcgttctga accccggcgt gcaaaccgaa tcggtcgtcg cgaccagcct
3586741 ttacagtcgt ctcaactgct cgatcgtcaa taccggcgct cagacggtgg tggcgtcaac
3586801 caacaatgcg atcatcgcga catgcactcg ctagatctgg gatctagctg agacccagtt
3586861 cccgcatgcg ttggtcgtgg gtctgctgca accggtcgaa gaaggcacca agctggctca
3586921 gtccaccact accggacacc accaggtcga ccagctcgtc gtggtcggcc aacaccagct
3586981 gggcctgcgt tatcgcctcg ccgagcagac gacgcgacca cagcgccagt cggctgcgct
3587041 gtttgccgct ggccgtcacc gctgcgcgca cttcggcgac gacgaactga gagtgcccgg
3587101 tctccgacaa cgccgcccgc accacgtcag caacctcgtc aggcagcccg tcggcgatct
3587161 ccagatacaa atcggcggcc aacgcatcgg caacataggt cttcaccagg gcttccagcc
3587221 atgtgctcgg cgtcgtcagc cggtggtagt tttctaacgc tgaggtgtac ttcgacatcg
3587281 ccgacaccac gtcgacgccg cgacgttcca acgcattgcg cagcagctcg tagtgcccca
3587341 tctcggcggc ggccatggat gccatcgaga tccttccccg cagatccggg gccatgcgcg
3587401 cctcatcggt caatcggtag aaggcggcaa cttcgccgta ggccagcaac gcgaacaatt
3587461 cgttgacgcc gggatgatcc gccggcagcc gtggcctggg tgaatcggcc acctgatcgg
3587521 cggatgaggg cgatggcatg gcaacactct agtaggcagg ctcagcggca aatgggaacc
3587581 tgctggccga ccagctatca tgctcgttag gtggcggcat tggttcgact gccgctaccg
3587641 gcgaaatgtg cgtgcatgga gtctgccccg cctggactgt gctaggggcc ggcgactcgg
3587701 cgacgtaatc ggagtcggaa ctcatgcgcg cgtgaaccgc gacagagaaa caccgacaca
3587761 cgaccgacac cgtcaccgaa aggccgctta ccctcgtatg accgcagtga aacacacaac
3587821 tgaatcaaca tttgccaaac ttggagtccg cgacgaaata gtccgcgcat taggggaaga
3587881 gggcatcaaa cggccctttg ctatccagga actcaccctg ccactcgcgc tcgacggcga
3587941 ggacgtgatc ggccaggccc gcaccggcat gggcaaaacg ttcgcttttg gcgtgccgct
3588001 gctgcagcgc atcacctccg gcgacggcac gagaccgctc actggcgctc cgcgggccct
3588061 ggtcgtagtc cccacccgcg agctgtgtct acaggtcacc gatgacctgg ccacggcggg
3588121 caagtacctg accgccggcc ccgacacaga cgacgctgcc gcggtacggc gccggctgtc
3588181 ggtggtgtcc atctacgggg gacggcccta cgagccgcag atcgaggcgc tacgcgccgg
3588241 cgccgacgtc gtggtcggca ccccgggtcg gctgctcgac ctgtgccagc agggccacct
3588301 gcagctgggc gggctatccg tgttggtgct cgacgaggcc gacgagatgc tcgacctggg
3588361 cttcctgccc gatatcgagc gaatcctgcg gcaaattccc gccgaccgac agtcgatgtt
3588421 gttttcggcg accatgccgg acccgatcat cacgctggcc cgaacgttca tggtccggcc
3588481 cacgcatatc cgggctgagg caccacattc ctcagcggtt cacgacgcga ccgagcagtt
3588541 cgtctaccgc gcccatgcgt tggacaaagt ggagttagtc agccgggtgc tgcaggctcg
3588601 tgaccgcggc gcgacgatga tcttcacccg caccaagcgg accgcccaga aggtcgccga
3588661 cgagttgacc gagcgcggtt tcgcagtcgg cgccgtgcac ggtgatctcg gacagctggc
3588721 acgcgagaag gcgctcaagg cgtttcgcac tggcggcatc gacgtattgg tggccaccga
3588781 cgtggccgcc cgcggcatcg acatcgacga cgttacccac gtgatcaact atcagtgccc
3588841 cgaagacgag aagatgtacg tccaccgcat cggtcgcacc ggccgtgccg gccgaaccgg
3588901 ggtcgcggtc accctggtgg actgggacga gctgccccgt tggagcatga tcgaccaagc
3588961 actgggcctg ggctcccccg atccggccga gacatactcc aactcgccgc atctgtatgc
3589021 cgagctggcc atcccggcca cggccggcgg taccgtcggc ccggcgcgca aatcgcaggg
3589081 caggcgacgt gacaccgact gcgacggcca gaaaacggca cagcacgccc gcaatacccc
3589141 caggcgtcgg cgcacccgcg gcggcaaacc cgtcaccgga caccccggca ccaacccaat
3589201 cagcagccca atcgtgggcg gcgacgccac ctcggagccg ggctccggca ccgcatcaga
3589261 ttccgggtcc gatgttgtgt ccggctcccg gtccggcaac ggcgaagctg cgcgacgccg
3589321 tcgtcgccgc cgccgacgcc cgacgcacgc ccaggacggc ttcgccgcgc gggctaactg
3589381 acccgcccac cgcatggtta aaccggagcg ccgcaccaag accgatatcg cggccgccgc
3589441 gacgatcgcg gtcgtggtgg ccgtggccgc gtcgttgatc tggtggacca gcgacgcccg
3589501 cgccaccatc agccggccgg cggcggttgc ggtgcccacc ccggccccgg ctcgcgaggt
3589561 cccgacctcg ctgaagcagc tgtggaccgc cgccagccca gccacccgcg ttcccgtggt
3589621 ggtgggcgga acagtggcta ctggcgacgg acgccaggtg gacgggcgcg acccagccac
3589681 cggtgagtcg ctctggagtt acgcccgaga caccgatctg tgtggggtga cctgggtcta
3589741 ccactacgcc gtcgcggtct atcggtacga ccggggttgc ggtcaggtca gcaccatcga
3589801 tggatccacc ggtcgccggg gagccgcccg cagcggctac gcggatccgc gggtgcgtct
3589861 tttttccgac ggcaccacgg tgttgtcggc cggggacacg cgcctggaac tgtggcgttc
3589921 agacatggtc cggatgctgg cctacggcga gatcgatgcc cgggtgaaac cgtcgaaccg
3589981 cggcctgcag tccgggtgca cgctggagtc ggcggcggcc agctcggcgg ccgtatcggt
3590041 gcttgaagcg tgtacgaacc aggctgacct gcggcttgtg ctgttacgcc cgggcaagga
3590101 ggacgacgag cccatccagc gcattgtccc ggaaccgggg gtccggccgg gttcgggcgc
3590161 ccgggtattg gtggtatcgc agaacaacac cgccgtgtac ctgcctgcaa gatcaggcgc
3590221 gcaaccgaga gtcgacgtga tcgacgagac cggcgccaca gtttcgagca cgctgctggc
3590281 caagccaccg tcaacttcgg ccgtggcgtc gcggaccggc aacctggtga cctggtggac
3590341 gggcgacgcg ttgttggtct tcgacgcggg caacctgacc cagcgctaca ccattgccgc
3590401 tggcgagacg actgcgccgg tggggccagg ggtgatgatg gcaggtcaac tcctggtgcc
3590461 ggtcaccggc gggatcggtg tctatgaccc ggtcagcggt gccaacaacc gttatatccc
3590521 ggtgacccgg ccgccaagca cgtcagcagt gatcccggca gtttctggat ccagggtcat
3590581 tgagcaacgt ggcgacacac tagtcgctct gggttgatcg cctatgttgg cgcgagcaga
3590641 cgcaaaatcg cccgaaaccg atggctttcg ggcgattttg cgtctgtcgc gctacaggtc
3590701 caccgtgaag gtgggcagcg gcctacctgt cttccagtgt ttgagcagcg cctgcgccag
3590761 ctcgcggtag gccaccgcgc ctttgttctt gcgcccagcc atcaccgacg agcccgaggc
3590821 gctggcctca gcgaagcgca cagtacgggg gatgggcgga gccagcacct gtaggtcgta
3590881 gcggtcggcg acatcgagca acacgtcacg ggtgtgggtg gttcgagagt cgtacagcgt
3590941 cggcagtgca cccaacaacc gcagattcgg attggtgatc tgctggacat cggcgaccgt
3591001 ccgcagaaac tggccgacac cccggtgcgc cagcatctcg cactgcagcg gcacgatggc
3591061 cttgtcggcg gccgtcagcc cgttgagggt gagcacaccc agcgacggcg gacagtcgat
3591121 gatgaccacg tcgaaccggt cggagaattt ggccaacgcg cgtttgagcg cgtactcacg
3591181 gcctgcccgc atcagcagca ttgcctcggc gcccgccaag tcaatgttgg ccggcagcaa
3591241 cgtcattccc tccatggtgg tgaccagcac ggcgttgggc tcgacttcac cgagcaacac
3591301 ctcgtgcaca gacaccggta gtttgtcggg atcttgacca agggagaagg tcagacaacc
3591361 ttgcggatcc agatcgacga gcagcacgcg ccgtcccttt tccaccatcg ccgcaccgag
3591421 cgaggcgacc gtagtcgtct tggccacccc gcccttctgg ttggccaccg ctagcacccg
3591481 ggtatcagtc ataggcgccg ctctcccccg caagcggcag ggacccccac ctcatcgtgc
3591541 tctcccttcg tcgtcgcccg cgcagtcaca gtgtcatcct ggcatgctgc tcgcacagtg
3591601 gttcgggcga caggcctagg atgtcgtcgg gcacaatctg tcggtatggg cgtgcgcaac
3591661 caccgattgc tactgctccg ccacggcgag accgcttggt cgacgctggg ccggcacacc
3591721 ggcggtaccg aggtcgagct gaccgatacc gggcgaacgc aggcagagct ggctggtcag
3591781 ctgctgggtg aactcgaact tgacgacccg attgtcatct gtagcccgcg tcgacggacg
3591841 ttggatactg ccaagttggc cggcctgacg gtgaatgagg taactgggct gctcgccgaa
3591901 tgggattacg gttcctatga gggccttacg acgccgcaga tccgggaatc cgaacccgat
3591961 tggctggtgt ggacgcacgg ctgcccagct ggagaaagcg tcgcacaggt aaacgatcgc
3592021 gctgacagcg ccgtcgcgct ggccctggag cacatgtcct cacgcgacgt gttgtttgtc
3592081 agccatggcc acttctcccg cgcggtgatc acgcgctggg tccagctacc gctcgccgaa
3592141 ggcagccgtt tcgcgatgcc caccgcctcg atcgggatct gcgggttcga gcacggcgtg
3592201 cgtcagctcg ccgtgctcgg gttgaccggt catccgcagc cgatcgcagc cgggtgagcg
3592261 cacacgtggc aaccttgcac ccagaaccac cgttcgcact gtgcggacca agaggcaccc
3592321 tgattgcccg cggggtgcgg acacgatact gcgacgtgcg ggccgcgcaa gcggcacttc
3592381 gctcaggtac agcaccaata ctgttgggcg cgttgccttt cgacgtgagc agacccgccg
3592441 cattgatggt gccggatggc gtgctgcggg cccggaagct gcctgactgg ccgaccggcc
3592501 cgctgcccaa ggtacgcgtc gccgccgccc ttccgccacc tgccgactac ctgacccgga
3592561 tcggccgcgc acgggatctg ctggccgcct tcgacggccc gttgcacaaa gtggtgctcg
3592621 cgcgcgccgt gcaactgacc gccgatgctc cgctggacgc gcgggtactg ttgcgcaggt
3592681 tggtcgtcgc cgacccgacc gcttacggct atctcgtcga cctcacctct gcgggcaacg
3592741 acgacaccgg ggcagccctg gtcggcgcca gcccagagct tctggtcgca cgatccggca
3592801 atcgcgtcat gtgcaagcca tttgccggct cagccccacg cgccgccgac cccaaactcg
3592861 acgccgccaa cgcggccgca ctagccagtt cggccaagaa ccgacacgaa caccaattgg
3592921 tcgtcgacac gatgcgggta gccctagagc cactatgcga ggacctgaca atcccagccc
3592981 agccccagtt gaaccgcacc gcagccgttt ggcatctgtg caccgcgatc accggccggc
3593041 tgcgcaacat ctcgacgacg gcaatcgatc tggctttggc gctacatccc accccggcgg
3593101 ttggtggggt cccgacaaaa gctgccaccg agctcatcgc cgaactcgag ggcgaccgtg
3593161 gcttctacgc cggcgcggtt ggttggtgcg acggccgggg cgacggccat tgggtggtgt
3593221 ctatccggtg cgcgcaactt tcggctgatc gacgcgcagc ccttgcgcac gctggcggtg
3593281 gcatcgtcgc cgaatcagac cccgatgacg aacttgaaga aaccacaacg aagttcgcca
3593341 cgatattgac cgcactggga gttgagcagt gaccgatacc atccgccgcg ctacaccggc
3593401 ggataccgcc gacatcgtgg ccatgattca cgcgctgggc ggaattcgag tatgccgccg
3593461 atcaatgcac tgtcaccgaa acacaaatac atacagcact tttcggagat ttcccgacga
3593521 tgcgaggcca cgtcgctgag gttaatggcg gagttgccgc gatggcgctg tggtttctga
3593581 acttttccac ctgggacggc gtcgcgggca tctatgtgga ggacttgttc gtctggccga
3593641 ggtttcgccg ccgcggcttg gcccgtggcc tgctgtcgac gctggccaga gaatgcgtcg
3593701 acaaccgcta cacgcggttg gcctggtcgg tgctgaactg gaattccgat gcaatcgcac
3593761 tgtatgaccg catcggcggg caaccgcagc acgagtggac tatctatcga ctgtcaggac
3593821 cgcggttggc tgcgctggcc gcaccacgct gatcacgccc ggcggcccag cggatcgaag
3593881 gcggactgaa cagcaatacc agcacgccaa gcgcgatgat tcccaccggg atcccgatcg
3593941 ccggctgatg cgaacccaca atcagatacc acgccaccgg cagcagcagc agctgggcga
3594001 acaccgccag cccgcgaccc caaagcttgc caaccgccag cctgcatccg gcggcgagca
3594061 ctgctccgcc gaccagtacg aaccaacctg cggtgcccag gccattgacg atgtgctggt
3594121 cggcgcccgc gagtccgcgc accagcaacg ccgcggccac caccagggcg gccccaccct
3594181 gcacggcgac gatcagtccg gcgccgcgca cggcggccgg ggctcgaaca ggcacagcat
3594241 cagcgtagtc acccggccgt gaccggcccg catcgtcaca ccacccaggc ccattgccgt
3594301 cctcctcaac gggccgaccc ggcccgcatc gtcacacggc ctaggcccat tgccgtcctc
3594361 ctcaacgggc cgacccggcc cgcatcgtca cacggcctaa gcccattgcc gtcctcctca
3594421 acgggccgac ccggcccgca tcgtcacacg gcctaagctc gtgcgtcatg cgtgcagtgc
3594481 tgatcgtcaa ccccactgcg accgccacca caccagccgg ccgcgacctg ctggcgcacg
3594541 ccctcgaaag ccgccttcag ctcacggttg agcacaccaa ccaccgcggt cacgggaccg
3594601 aactcggaca ggcggcggta gccgacgggg tggacctggt cgtggtgcat ggcggcgatg
3594661 gcacggtaag cgccgtagtc aacggcatgc tggggcgccc cggcacgacg ccggtccgac
3594721 cggtgccagc cgttgcggtt gtgcccggcg gctcggccaa cgtactagct cgcgcgctag
3594781 ggatttccgc ggacccgatc gctgccacca accaactcat ccagctgctc gacgactacg
3594841 gccgccacca gcagtggcgc cgcatcgggc tgatcgactg cggtgagcgg tgggcggtgt
3594901 tcaacgccgg catgggcgtc gacgccgagg tcgtggccgc ggtagaggcc gaacgcgaca
3594961 aaggcggcaa ggttacggcg tggcgctata ttcgcgctgc ggtgcgcgcg gtgctcgcct
3595021 gcactcgtcg cgaaccggct cttacgctgc aacttcccaa ccgcgatcca attaccggag
3595081 tgcactttgt gttcgtgtcc aactccagtc cgtggactta cgcaaacaac cggccggtat
3595141 ggaccaatcc cgactgcagg ttcgagtcgg ggctgggagt gttcgccacc accagcatga
3595201 aggtggtccc gaccctgagg gtggttcggc agatgttcgc aaaacagccc aagttcgagt
3595261 tcaaccacgt catcaacaac gacgacgtcg cgtgtctacg cgtcacctcc atggggcccc
3595321 cgatcgccag ccaattcgac ggggactacc tcggcgtgcg cgagacgatg acgttccgag
3595381 ctgttcccga cgccctcgcc gtagttgccc cgcccgcaag aaagcggatc tgagctgcag
3595441 aaacaaagat gtgatgggtg tgcgacacaa acgttgggcg aaactggcag cgtagtgtag
3595501 tacaactggg taagggctgt ggaacgagat cgccagagtg agatagccca cgcgcttacg
3595561 taacactatt gacatctgtt gagcctgtga aacgatcaaa aggttgcatg tagagaaatg
3595621 taggggtaca gaagcctttc ttgtgcaccc gttaccagcc aagaagaaac gcctgtgcgt
3595681 accgctgcgc acatagtgag gagtaacgac taatggattg gcgccacaag gcggtctgtc
3595741 gtgacgagga tccggaactg ttcttcccgg taggaaacag tggtccggca cttgcgcaga
3595801 tcgctgacgc gaaactggtc tgtaatcggt gcccggtcac cacagagtgc ctcagctggg
3595861 cactgaatac cggccaggac tcgggcgtct ggggaggcat gagcgaagac gagcggcgcg
3595921 cgctgaagcg tcgcaacgcc cgcacgaaag cccgtaccgg ggtctgacga ctcagttctg
3595981 cacagtgcgg ccccgacata cgtcggggcc gcactgttgc gtagcgcgct acagcatcaa
3596041 ccgtccccgg cgtccgaccg gtacccgtag caccacatcg gtgccacgtt cgcgggcgtc
3596101 ccgcatacct aacgagccgt ccaattccgc agagaccaag gtccgcacga tctgcaggcc
3596161 caggctgtcc gacttctcca ggctgaaacc ttgcggcaga ccaagcccgt cgtcgtgcac
3596221 gacgacatcg agccaacgcg cagagcgttc cgctcgaatc gtcacggacc cttccgccgc
3596281 cgccgggtcg aacgcatgct cgatcgcgtt ctgcaccagc tcggtgatca ccatgatcag
3596341 cgccgtggcg cggtcggagt cgagcacacc gaggtcgcca acccgattta tccggatcgg
3596401 cctgtccacc gatgccacat cgttcatgat cggcagaatc cggtcgatga cctcgtcaag
3596461 gttcacctgc tcgtccaccg acatcgacaa cgcatcgtgg accaaggcaa tcgacgacac
3596521 tcggcgcacc gactcgatca gcgcttcccg cccctcggcg ttggacgtcc ggcgagcctg
3596581 cagccgcaac agcgcggcca ccgtctgcag gttgttctta acccgatgat ggatttcccg
3596641 gatcgtggcg tccttggata tcagggctcg gtcgcgccgc ttcacctcgg tcacgtcgcg
3596701 gatcaatatc gcggcgccga cattgcgacc agctaccacc agcggcagag tccgcagcag
3596761 caccgtggcg ccgccggcgt cgacctccat ccgcataccc tttccatccc cggccagcaa
3596821 gtcctgcaca tgctcgtcta cctcgtgcgc ctcgaacggg tccgagatca gcgggcgcgt
3596881 cgcgtcaatg agattgacgc cctccaactc ggtggtcaaa cccattcggt ggtaagccga
3596941 tagggcattg gggctggcgt aagagaccac accgtcgaca tcgagacgga tgaagccgtc
3597001 acccgcgcgc gggctagatc gcgacatcgc cacgtcccct gcgtcgggaa aggtgccctc
3597061 cgccagcatc cggagaagat ctgtggcgca caaccgatag gcggtctcca ggtggccgga
3597121 tctacgtcgc gccgccagtt cgggttgatg ccgtgtcagc accgccacca cctgatcgcc
3597181 aaagcgcacc ggggagactt cgacactgtg gccgtcgtgt tgacatgaat tctgttggcc
3597241 gacagcgcct tcccgtcccg ggacaccacc ggagaaggtc gcggcgacca gcggcatgct
3597301 attggcggcg acgacggtgc ctaccgcgtc ggtatgcacc accgtcggcc cggtgttcgg
3597361 ccggcattgc gcaacgcaca ccaggacacc gtcgtcgcgg cgaacccaca tcaggtaatc
3597421 ggcaaacgac aagtcggcaa ggagctgcca ctccccgacc accgcatgca ggtggtccac
3597481 cgcgctgccc ggcagcaccg tgtgttcggc gagcagatca ccgagtgtgg acatgagtga
3597541 ctatcaacga ctagctgatc accgcgataa ggtcgccggc ctgaatgaca tcgcccaccg
3597601 ataccgccac cttgctgacc gttccggcag cttcggccag gacggggatc tccatcttca
3597661 tcgactccag cagcaccacg acgtcgccct tgtcgatctg atcgccttcg ttgacaacga
3597721 cttcgagaac gctggccacg atctcggcgc gaacatcctc ggccatcatc accccactct
3597781 tttcggccat gccgtatgct gactgctggt catcggactt ccatcaaact caggtatatc
3597841 gaaccataag aaccctgggg agcgcggcac gcgggctatt ggggtcgcgc gcgacgccgc
3597901 atgagaaact gggcaatgac cgggcggccg ctgcctgccc gcacctgagc aatgacggag
3597961 gttccgatgg ccaagcgtgg ccgtaagaag cgtgaccgca agtacagcaa ggccaaccac
3598021 ggcaagcggc ccaattccta acgcactgcg ctagggccct ccacggatga tggtggtccg
3598081 gcggatctct agccgaagac gctcccgcaa gccctcgggg gccctgtcgc ctcggcactt
3598141 ggtcccgatc aacgccttga tccgttcctc gagcccgtaa tgcctcaggc accccgggca
3598201 ggcctcgagg tgtcgccgca gcctctcgcg ggtttccggg gtgcattcac cgtcaagcag
3598261 ggtccacacc tcggcgatca cttccgcgca acccatgccg ccgtgggaat cgtcgtggtc
3598321 cgcgtgcgca tcggtcggac cgcaattttc gctcactggt gcaccatcct tgtgtcggtg
3598381 atctcggatg gattgccgat gtagaggcgc cgctgggtta gcgccccgcg cgcttgacag
3598441 ccgtgatgtc catcatgagt tttgcggagt ccggcggttg ccccggacgc gccgaccgtc
3598501 gacagggcca agcgccgacg agcgccgaac gactcgcccc gcacgccgac gcccagcccg
3598561 aattgctggc ctgcttggcc ggcgtcgccc gctccaccgg ctagtccgac aaagtcaccc
3598621 acgtcgggtt cggttgggcg gcagacaaac aactccgcaa cggtgtctgc gacttcgccg
3598681 gcgacagccg ccgagccaac ctctaggccg ccgacctgca caaccgcacc cgagcccgcg
3598741 gccacgacca ccggcacgcg gtacgcatcc tcgcccgcgc ctggctttac gtcatctgac
3598801 accgctggca agacggcatc gcttacgacc ccacccaaca ccgagccctg caggctctcc
3598861 ttgaccaagt tcgccaaacg gcggcttgac accgggctgc tcatgacgac accccctcgt
3598921 gcgcctgctc gcccctggca aacccccgat ccctggccac atcggctaaa agaccgcgca
3598981 actgacgtcg gccgcgatga agcctcgaca tcacggtgcc gatcggagta tccatgatct
3599041 cggcgatctc cttgtagggg aaaccttcga catcggcgta gtagaccgcc atccggaact
3599101 cttccggcaa tgcctgcagc gcctctttga tctcggtgtc cggcaacgct tctaacgctt
3599161 cgacttcagc cgagcgcagc ccggtcgagg aatgctcggc gttggacgcc agttgccaat
3599221 cggtgatctg ctcggtcgga tactccgccg gttgccgctg tttcttgcga tagctgttga
3599281 tgtaggtgtt ggtcagtatc cggtagagcc aggccttgag attggtaccg tgccggaacg
3599341 aacgaaatcc cgcataggcc ttcaccatcg tctcctggag caagtcctcg gcgtcggccg
3599401 gattgcgcgt catccgcagc gcaccgccgt acagctggtc caacagggga atcgcgtcgc
3599461 gctcgaaacg cgcggtcaac tcctcgtctg tctcctcaga cggcccaggc tgcagacccg
3599521 ccgaaccggt tacaccatcg atgtcggcca tcttgattaa ctgggtccct tcgtttgcgg
3599581 tgtcgccgga cagcaccggc gcggacaccg gacgtgcgag catgcgagcc aaccgcttct
3599641 cacccaacag gctcgtcgcc gttgacacca gactcccctc gtcccaatgt agaggccgcg
3599701 accgacactg tctgcaccgg tctggccagc cacgtggctg caggaaccga accaatcaac
3599761 cgtgttcgcc agcgggttat ttccagcgct gaatcgcatg cggcctgtcc cgcagtccgg
3599821 tggaatcgag cagggcgtta gggtgacgcc atgtcactca acggcaagac catgttcatc
3599881 tctggcgcca gtcgcggtat cggccttgcg atcgccaagc gggccgcgcg cgacggcgcc
3599941 aacattgcct tgatcgccaa gaccgccgag ccgcatccaa agctgccagg cacggtgttc
3600001 acggccgcca aggaactcga ggaagccggc ggccaggcac tgccgatcgt cggggatatc
3600061 cgcgacccgg atgcggtcgc gtccgcggtg gccaccaccg tggagcagtt cgggggcatc
3600121 gatatctgcg tcaacaatgc ctcggcgatc aacttagggt ccatcaccga ggtgccaatg
3600181 aagcgtttcg acctgatgaa cggcatccag gtgcgtggca cctacgcagt atcccaagcg
3600241 tgcattcccc atatgaaagg ccgtgagaac ccgcacatcc tgacgctgtc cccgccgatc
3600301 ctgctggaga agaagtggct gcggccgacg gcctacatga tggccaagta cggcatgacg
3600361 ctgtgcgcgc tgggaatcgc cgaggagatg cgcgccgacg gcatcgcgtc gaacacgttg
3600421 tggccacgca cgatggtggc caccgcggcg gtacagaacc tgctgggcgg cgacgaggcg
3600481 atggcgcggt cccgcaagcc cgaggtatac gccgacgcgg cctacgtcat cgtcaacaag
3600541 cccgccaccg aatacaccgg caagacgctg ctgtgcgagg acgtgctcgt cgaatccggc
3600601 gtcaccgact tgtcggtcta cgactgcgtc ccaggtgcga cgctcggcgt cgacctgtgg
3600661 gtggaagacg ccaacccgcc ggggtacctc ccggcctagc gacagcaaaa ccctgatcct
3600721 cgagttgccc gacgagcggg ccgtcgcgat cgtgccggtg ccgtcgaagt tgtcgctgaa
3600781 ggcggccggc ggccctaggg gtgcccaaag cggccatggc taaacccgct gccgccgaac
3600841 aagccaccgg ctacgtggtc ggcggcatct ccccgttcgg tcagcgcaag cggctgcgga
3600901 ccgtggtcga tgtgtcggcc ttgagctggg accgggtact gcggtgccgg caaacggcat
3600961 tgggccgtca cggtggcccc gccggacctg atcaccttga tcagcgcgat catcgctaac
3601021 atccgggcct agcgccgtac cggaaatcgg cgaggacttc accgatggcg tagcgcgcgc
3601081 tggccgccag cggcgggttg gtgtcttggt agtacgggag cgcgatcaag gcgatggcca
3601141 gagctctgcc gcgcccgcgc atccagtcgt cgtcggcggc gccgaccgcg acgcggaact
3601201 gagcacgggc gggcgccgac aggaggttcc acgcgatgat caagtcgacg ctggggtcac
3601261 cgacgcccat cagaccgaag tcaatgacgc ccgtcaagcg tccttgcgct gtcaggatgt
3601321 tgaaccggga caggtcaccg tggaaccaca tcggcggccc cgcatacgga ggaacgcgta
3601381 gggctgattc ccacgcggca gttgccgcgt ggacgtcgat gatcccgtcg agggccgcca
3601441 gcgctgcgcg tacctcggca tcctgctccc ccagcggcgc accccgcttg gcgggcggcc
3601501 cgcccatggg gtcggtggcc cgtaaggcgg tgatgaagtc agccaggtcc tcgacggccc
3601561 gattgggctc gacgaactcg gctgccgacg ggttctcacc cgcaacccag cggcacactg
3601621 accacggcca accgaacccc tcagccgggc tccccaaccc caccggaact gggctggcaa
3601681 cgcctagatg cgcagcgatc cgcggcagcc actgttgctc ggtccgaagg ctctcgatgg
3601741 cccagccaat gcgcgggatg cgcacggcca ggtcctcgcc tagccggtac attgcgttgt
3601801 ccgtgcccgc cgagcgcacc ggtgcaatgg gtagatccgc ccactgtggg aattgtgcac
3601861 gcagcagacg ccgcaccaga tcctcgtcga tatccacctc atcggcgtgc atctttgccc
3601921 ttaggacacg ttcgtaccgg tcgaagacgg ttccgtcctg ctcacagatc cgccgcacga
3601981 aagcaaagcc cgcccgcaac gccaccctcg ccgatgcgga gttctccggc tccaccttga
3602041 tcaccgcttc ggtcgcgccg tgttcggccg catactggca caccagatcg actgcgcgag
3602101 tggcgagtcc acgccctcgc cagctggggt agagcccata ggcaacgttg acctgcccgc
3602161 tagccagccc ctcgccgtcg aaacgcagat caatcgtacc cactattgtt tcggcaaccg
3602221 tcctgatgcc gaaagagcgc agcggcccgc cggtcaccca ttgctcgcgg cagtgccgga
3602281 tgtacgcttc gacgcttgct cgagtcgagg gcataccgct aagccaacgc actagccgtt
3602341 cgtccccccc agccagatgc gcatcgacat cgtccaggca cagtggcgat agagtgacga
3602401 tcccgtctga tagcccgtcg gacagcttcg caaagcgcac cccgcgattg tcggactcac
3602461 actggcttca ggcaaacctg ccgcgagcgc ccggcgagcg taatggcgcg gcaagaaatc
3602521 gcgcttggat tcgccgcagc gtcacacgcg tgggcacaga ccctcacagc agctggatct
3602581 gctcgggctg cgacctggcc ggctccaaca gctcaggccc gttgttgcgc acgttgttga
3602641 ccaacgtgga cacttggcgc agcgcgatgt cgcgcacatc cggcgggcgg gccagcagct
3602701 caggatccgg cggggcgtct ggattcagcc agtcgtccca gtcctcttcg gccagcagca
3602761 gcggcatccg gtcatggatc tcggccagct cgcccacggc atcggtggtg atcaccgtgc
3602821 agctcagcag cggtggggcg gacctgtaag acttccaaac cgaccacagc ccggccgtga
3602881 acaacagggc gccgtcgtgg cggtgcagga agaacggcgt cttggcgttc ggcctccccg
3602941 gggtggcgtc ggggtcgacg cgccattcgt accagccgtc catcggcacc aggcaacgct
3603001 tacttctgac cgcactccgg aacgccggcg acgtggcgac cttatcggcg cgggcgttga
3603061 tcagcggtgg gcctttggca tcgggtgcgc cgccgggccc ggccttgatc cacgacggaa
3603121 tcagtcccca gcgcatgagc cgcacccggc gggtgggctc gtcgtcgggc tcgctgtggc
3603181 gggacaccac tgtcgcgatc gtgtcggtgg gtgccacgtt gtagctcgtc ttcccgccac
3603241 cgcacccggt ggcctcgtct atggccgtga ttttctcggc cagctgggcc ggatcagtgg
3603301 tgaccgcaaa ccgtccgcac atgcttccta tggtgcctgg tacccacgac acccgccgac
3603361 acggcaggat gaagcggtga agacatggcc agccccaacg gcgccgacgc cggtgcgcgc
3603421 taccgtgacc gttccaggct cgaagtcgca gaccaaccgg gcgctggtgc tagcggcgct
3603481 ggcggccgca caaggccggg gcgcatcgac catctccggc gcgctgcgca gccgcgacac
3603541 cgaactgatg ctggacgcgc tgcagaccct gggcctgcgc gtcgacggtg tgggttcgga
3603601 actgacggtc agcggccgaa tcgaaccggg gcccggcgct cgggtggact gtggcttggc
3603661 gggcacggtg ttgcggtttg ttccgccgct ggcggcgctg ggctccgtcc cggtcacctt
3603721 cgacggcgat cagcaagccc ggggacggcc catcgcaccg ctgctggatg cgctgcgcga
3603781 gctcggcgtc gccgtcgacg gcaccggtct accgtttcgg gttcgcggca acgggtcgct
3603841 cgccggcggc accgtggcca tcgacgcgtc ggcgtcctca cagttcgtgt ccgggctgct
3603901 gctgtccgcg gcatcgttca ccgatggcct gaccgtccaa cacaccggtt cgtcgctgcc
3603961 gtctgcgccg cacatcgcga tgacggcggc gatgctgcgg caagccggag tcgacatcga
3604021 cgactcgaca ccgaaccgtt ggcaggtgcg ccccggtccg gtggcggcgc ggcgctggga
3604081 catcgaaccg gacctgacca acgcggtggc tttcctgtca gcggccgtgg tcagcggcgg
3604141 caccgtgcgc atcaccggct ggcctagagt cagcgtgcaa cccgccgacc acatcttggc
3604201 aattttgcgg cagctcaatg ccgttgtcat tcatgctgat tcatccctcg aggtgcgcgg
3604261 tccaacggga tacgacgggt ttgacgtcga cttgcgcgcc gtcggcgagc tgacgccatc
3604321 ggtcgcggcg ctggcggcgc tggcatcccc gggatcggtg tccagactaa gcggcattgc
3604381 ccatctgcgg ggccacgaaa ccgaccggct cgccgcgctg agcaccgaga tcaaccggtt
3604441 ggggggcacc tgccgggaaa cacccgacgg tctggtgatc accgcgacgc cgttgcggcc
3604501 cggcatctgg cgggcatacg cggaccatcg aatggcgatg gccggcgcga tcattgggct
3604561 gcgggtggcc ggagtcgagg tcgacgacat cgccgccacc accaagacgc tgccggagtt
3604621 tccgcggctg tgggccgaga tggtcggacc cggccagggg tgggggtacc cccagccgcg
3604681 cagcggccag cgggcgaggc gggcaaccgg gcaggggtcc ggcggttgag gcccggcgac
3604741 tacgacgagt ccgacgtcaa ggtgcgctcc ggcaggagtt cgcggccgcg gaccaagacc
3604801 cgtcccgagc acgccgacgc ggaggccgcc atggtggtca gcgtcgaccg cggccgctgg
3604861 gggtgtgtgc tgggcggccg ccccgatcgc cgaatcacgg cgatgcgcgc ccgcgagctc
3604921 ggccgcaccc cgatcgtggt cggcgacgac gtggacgtgg tcggtgacct gtccgggcgg
3604981 cccgacaccc tggcccgcat cgtgcggcga gcaccgcgac gaaccgtgtt gcgacgcacc
3605041 gccgatgaca ccgaccccac cgagcgggtg gtggtcgcca acgccgacca actgctgatc
3605101 gtggtcgcgc tggcagaccc gccgccacgc accggcctgg tcgaccgggc gctgatcgcc
3605161 gcctacgccg gcgggctgac cccgattctc tgcctgacca agaccgacct cgccccggcg
3605221 gaaccgttcg gcaagcagtt cgccgacctg gaattgaccg taaccgccgc aggcgtcgat
3605281 gatcctctgc tcgcggtggc ggacctgctg gccggcaaga tcaccgtcct gctcgggcat
3605341 tccggggtcg gcaagtcgac attggtgaat cgtcttgtac ccgaagctga tcgggcggtt
3605401 ggtgaggtca ccgagatcgg ccggggacgg cacacgtcga ctcggtcggt ggcgctgccg
3605461 ttgggagata cgctgtccgg ttccggctgg gtgattgaca ccccaggaat ccgctcattc
3605521 gggttggctc atatccagcc cgacaacgtg ctattggctt tctctgacct cgccgaggca
3605581 acccgcgagt gtccgcgcgg gtgcgggcac atgggaccgc cggccgatcc cgaatgcgcg
3605641 ttggatacct tgtccgggcc cgctgcccgc cgcgccgcgg ccgcccggcg actactggca
3605701 gtgctcagcc agacttgact agccgcatgc tcgtcgcgcg ccgagcaatc ttaggctgcc
3605761 agatcgtcgg gttcggtgac cgacttagcc atacgcttgc tgcgccgccg accccgcacg
3605821 gcggcaatcg cggtctttaa cccccgacga cgtccggtca ccggatcggc gcccgcgaaa
3605881 cccggcccca gaccagcgaa catccgctca ctgcgggtct cgggtgcatc gtcagcgttg
3605941 tcacgtaagt acttatccgg caacgacagc ttggcaaggg tgcgccaggt cttgccgtac
3606001 tgcaccaaga acgagcccgt ggtgtatggc aagtcgtatc tgtcgcagac ctcacgcacc
3606061 cgcaccgaaa tctcgtgaag ccggttgctc ggcaggtccg gatagaggtg atgctcgatt
3606121 tggtggcaca gattgccgct catgaaccgc agcgccggcc cagcgttgaa gtttgcgctg
3606181 cccagcatct gccgtaggta ccactggccc ttcggctcac cgatcatgtc cgtcttggtg
3606241 aatttctctg cgccatccgg gaaatggccg cagaagatca ccgcgttgga ccacacgttg
3606301 cggatcacgt tggccaccac gttggcggtc aaagtggacc gatacgtcgc ccccggggac
3606361 aacgaggtca gcgccgggaa cgcgacatag tccttgaaca cctggcggcc cgctttggct
3606421 gagaattcac gcaaccgggt tttagcggcc tcgcggtcgg cccgaccctt gaagatcttg
3606481 ccgatctcca agtgctgcag cgcaactccc cactcgaagc cgatcgcaag gatggtgttc
3606541 cacaccacgt tgaagatgtt gtagcgcttc cagcgctggt cacgggtgac gcgcagcatg
3606601 ccgtatccga cgtcgtcatc cataccgagg atgttggtgt atttgtggtg cacgaagttg
3606661 tgggtgtagc gccagtgctt ggacgatccg ctcatgtccc actcccacgt cgaggagtga
3606721 atctccgggt cgttcatcca gtcccactgg ccgtgcatga cgttgtggcc gatctccatg
3606781 ttttcgatga tcttggccac gccaagggtc agggcacctg tccaccaggc gaggcgtcgt
3606841 gagctgccag ccagcagtag ccgaccggac acctcgagcg cccgctgtgc ggcgatggtg
3606901 cggcggatgt agcgggcatc gcgttcgccg cgcgattctt caacgtctcg gcggatggca
3606961 tctagctcgg cggccaggtt ttcaatgtcg gcgtccgtca gatgcgcgaa tacgtcgacg
3607021 tcagtgatcg ccatcgtctt ctccctgcgt catacggccg atgacctacg ctatcgtaac
3607081 ttacgattcc gtaggttacc tatgagtaac actagatgtc cagcacgcaa tcacccgagg
3607141 cggccgacac gcaggtctgg acccgggttc cgggctcatg ccgctggccc gtgcgcagat
3607201 cccgaacatg gccttccacc aggtcgacca cacacgactg gcagatgccc atccggcagc
3607261 cgaagggtag ctgcacgccg gcgccctcac cggcgtccat caacgacgtg gcagcatcgg
3607321 cggctacgct cttgccactt cgggcgaacg tgacggtccc gcccgctcca gcgggcgccg
3607381 ttttggacac tgcgaaccgc tccaggtgca gtcggtcgct ggcacccgcc gatgaccaga
3607441 ccttgtcggc ctggttgagc acgccctccg gcccgcacgc ccaggtctgg cgttcacgcc
3607501 agtccggcac ctgctgaccg atccgggtca ggtccagccg gccctgggcg cgcgtctcgc
3607561 gcaccgacaa ccgataaccg ggatggtcgg ccgccagggc agccagctcg gcaccgaaca
3607621 tcacgtcagc tgcggtgggc gccgaatgca ggtgcactac gtcggtgatt tggttgcggc
3607681 gcaccaacgt tcgaagcatc gacattaccg gcgtaatccc cgacccggca gtcaaaaaca
3607741 gaatcaacgg gggcgccgga tccggtaata cgaaattgcc ctggggcgca gccagccgca
3607801 caatggtccc tggctttacc ccggccacca agtgggtgga caggaagccc tcgggcatcg
3607861 ccttcaccgt gacggtcacc atgcgcgcgg acccggatgc cgccggactc gacgtcagcg
3607921 aatacgaccg ccagcgccag cgcccgtcga ccagcagccc gatcccgatg tattggcccg
3607981 gctggtagtc gaaactgaag ccccagcccg gtttgatgaa cagggtcgcg gagtcttccg
3608041 tctctcggcg gacccctagg atgcgccccc gcaattcccg cgcggaccac agcggatttg
3608101 ccaggtgaag gtagtcgtcg ggcaacaatg gcgtcgtgat gcgcgcggca atcttgcgca
3608161 gcgcatgcca gcccggatgc cggtcggctc cggcgacggt ggggcgcctg gtgtcgatga
3608221 tgctggcgtt aagcgtcgtg tgtttcttgc tcataggaag ctcctgctcg gccttagctt
3608281 ccgcccaaca aagctacggt accgtaacct acggttccgt atctaggccc ggacgcgcag
3608341 actgcgtcac acccacggca tcgtcagagc aggtccagca gaaatggcag ctcttggttg
3608401 gcgtaccagg cgagatcgtg gtcctgggcg tcaccgacca ccagctcagc gtcctcgtcg
3608461 cccaggtcag cggcatcgat gaccgcaatc gccgccatca cggccggctc agcgccggca
3608521 ttgtcgacat atgcggcgac aacctgatcg atcgtgattg gccccgccag cctgacgacc
3608581 gcgtcatcaa gatcgggacg gtacgtggca tcgtcgacct cggcggccag caccgcgcgt
3608641 ctgggcggca gggcgtctgc ggtggcgccg atgtccgccg ctagcagacg caacgacgcc
3608701 aacgccgctt cgcgcagcgc cacctcggca agctcctcgt cgtcaccctc ggcgtacgac
3608761 tcacgcaacg tcggcgtcac tgcaaaagca gtgccgttga ccggccacaa cgcgccatcg
3608821 gcaacgagtc gctgcaacat ggccagggtg gccgggatgt agacctgcgt caccgggcga
3608881 tcaacgtggc cacatagtcg tcgacgtatg tcgacaactc gcggggcgga cgcctgtagt
3608941 tgccactcac aagcggccgt ggcggcagct tgacctttgg cttttccaca tctgcgtagt
3609001 caatcgtgga cagcaagtgg gccatcatgt tcagccgcgc gtgctttttg atatcagact
3609061 ccaccacgta ccaggggctg acgggggtgt cggtatgcac catcatctcg tcctttgcgc
3609121 gcgaatagtc ctcccaccga tacaccgatt ccaggtccat tgggctgagc ttccattgcc
3609181 ggaccgggtc attccgtcga gccttgaatc ggcgcaactg ttcggcgtct gagactgaaa
3609241 accagtattt gcgaagcaga atcccgtcat cgatcagcat ctgctcgaaa atcggggtct
3609301 gccgcaaaaa caacacatac tcctgcggcg tacagaaacc catgaccttc tccacaccgg
3609361 cgcggttgta ccaggaccga tcgaagagca ctatctcacc tttggcggga agatgggcaa
3609421 tataacgctg gtagtaccac tgaccccgct cgcgatccgt cggcgcgggc aatgccgcga
3609481 tacgagccac tcgcgggttg aggtactcgg tgatccgttt gatggcgcca cccttaccag
3609541 ctccgtcacg gccttcgaag atgaccacca gacgcgcacc cgaatgccgg gcccactctt
3609601 gcagcttcac gaattctgtt tgcagccgaa acaattcggc ttggtagacg gcatcggaga
3609661 tcttgcgccg gcccggcgca gctgatctgt gtcccttcgc tctcgacgac gcgccgtcgt
3609721 tggtcgcggt gctcacatca acggatggta tatccacaca tcaccatcga cccctaacaa
3609781 ctaccgcgaa gcctccagaa gctcgtccag tgcttggctc aacagccccg gcagcagatc
3609841 gacatcgctc atcgcgtcgc ggtcggcatt gatgccgaaa tacaacatcc cgttatacga
3609901 cgtcacgctg atggccagcg cctggttgtg cagtagcggc ggcacggagt aggtctccag
3609961 cagcttggta cccgcaatgt acatctgcga ctgggttccg ggggcattgg tgatcaacag
3610021 attgaacaac cgtgccgaaa agctagtggc gacccgcacc cccatggcgt gcaaagtggc
3610081 cggtgctaac cccgacaacg tgacgatagt cctggcatcg accaggctgg cggcggtcgg
3610141 gttggattcg gtggcgtgcg cgatctgcga caaccgcact acggcattgc cctcccccac
3610201 cgggaggtca accaagaacg gtgtcacctg gctgatcgcc tgaccagggc cggttgagtc
3610261 gagttggtcg tcggcataga ccgacagcgg cgccatcgcc cgaacagtcg cggtcggtgc
3610321 cacagcttca ccgcgtgaca tcagccagtt gcccaaggca ccggcaatca ccgtcagcac
3610381 cacgtcgtgg agtcacagtc gtagcgagcc cgcaccgtgc gatagtcatc aagacttgca
3610441 cgggcaaccg taaatcgccg attacgcgac acggtggcat tgagcgggct actgggcgcg
3610501 gtgccccgtg ccaccgtgcg ggcgatatcg agaaccttgc ggcccgtctc gacgagttgg
3610561 ccggaattcg ttaccaaccc ggcgaccgcg gatccgacgg cctgtagttg tgcgcccggc
3610621 cgcaccagcc agtccccgac cgcgcgcagc agcaaccgcg tggtgccggg gtcccgttcc
3610681 gggacccaga tgtcttccgg aaacgccggt ggacgccgcg tccggtcggc gatcacgtgg
3610741 cctatcgcca gcgcggtcac cccgttgatc agggcttggt gcgacttggt gtagagggca
3610801 atgcgattct tttccagacc ctcgacgaga tacatctccc acaatggccg cgatttgtcc
3610861 agcggccgag cggccagccg tgcgatcagc tcgtgcagtt gctcgtcact acccggcgac
3610921 ggcagggccg accgccggac gtggtaggtg atgtcgaagt cgcgatcgtc gatccacacc
3610981 ggcctggcca ggcccaattt cacttcctgg actttctgac gatagcgcgg tatctgcggc
3611041 agccgctgtt cgacggtttc cagcagtgcc tcgtagctca atccggcacg cggacggcgc
3611101 aggatcaaca gcaacccgac atacattggg gtggctgtgt tctccagctg atagaaggag
3611161 gcgtccgatg cagacaaccg ggtgaccact acggccctgt cctccttgtc aattcgtcgc
3611221 gacgagtcac gtcgtcgccc acgctaacgg ttagcccgac cacttcacgg cgcgggtaca
3611281 cgcaagcccg cattgtgcga tgatggccag caaccaaacc gctgcgcaac actcgtctgc
3611341 cactctccag caggctcctc gttcgatcga tgatgctgga gggtgcccct tgaccatcag
3611401 tcctatcgcg aactcaccgg gcgacacctt cgccgtcaca cccgtcgtcg agtacgagcc
3611461 gccgccgcga aacatcccgc cgtgcgggca atcatcgcac gcagcccggc ggccgcacac
3611521 cccgcagcta gctcgccgac aaccaatcag gccgagcggc cgggcaccgg cagcggtcac
3611581 ctccacggcc aagtcaccgc ggctgcgtca agcggggacc ttcgccgatg ccgcgctacg
3611641 ccgagtgctg gaggtcatcg accgccgccg cccggtgggc cagctgcgcc ccctgctggc
3611701 acccggcctc gtcgactccg tgctcgcggt gagccgcacg gcggccggac accaacaagg
3611761 cgcggccatg ctgcgccgca tccggctgac accggccgga cccgacaccg cggacaccgc
3611821 cgccgaggtc ttcggcacct acagtcgcgg ggaccggatc catgcgatcg cctgccgggt
3611881 ggaacaacgg cccgccggta acgaaacccg atggctgatg gtcgccctgc acatcgggtg
3611941 agatcgccgg cccacaccct agttcgaagc tactgcggcg gccggcagcc caccgccggt
3612001 gtagcgggcc agtatcggac cgacgatcgc catgacgaac acatacgccg tggccaaggc
3612061 ggcaaccccc gggatcgagg caccggccag cccgatgatg atcaaagaaa actccccccg
3612121 ggcaacgagc gcggtgccag cacgcagctg cccacgccgt gccactccct cccgccgggc
3612181 agcgaacatc ccggtggcca ccttggtcgc tgcggtgaca gcggccaggg ccagcgctac
3612241 cggaagcatt gaaacgagct ttcccgggtc aaccgacagg ccgattccca ggaagaagat
3612301 cgtggcgaac aagtcacgca gcggagtcag caccatgcgt gcccggtctg cggtctcccc
3612361 ggtaagcgtg aggcctacca gaaacgcacc cacagccgcc gacgcgtgca gcgactcggc
3612421 caccgccgcc acgatcaagg tgatgcccag cacccgcaac aacaattgtt cggaatcagg
3612481 atgagtcacc aaccggccga catgatgacc ccaacgatac gacgccgcga acgccccaag
3612541 caaagcggcg atcgccaccg tcatgcccac gaccgcctcg agccagctgc cgtctgtcgc
3612601 gagaaccgcg aacagcggca agtaggccgc catcgcgaag tcttcgagca ccagcaccga
3612661 cagcacagcc ggcgtttccc ggttgccgag ccgacgcagg tcctccaaca gccgcgcgat
3612721 cacacccgag gaggaaatgt aggtgacccc ggccagaccg aggatggcaa caccgtccaa
3612781 ccccaaaagc cagcccgcca ccgcaccggg cgtggcgttg aggacgatat cgacacccgc
3612841 cgacggcagg tggtggcgca gactgctggc gaactcggtc gcagaaaact ccagacccag
3612901 ggccaaaagc aacaacacga caccgatggg cgcaccggta gcgatgaact caccggcggc
3612961 ggccaccccc aagatgccgc cattgcctaa cgacaaaccc gccaacaaat acaccggaat
3613021 cggcgacaac gcgaatcgtc gtgccactgc acccagcacc gcaagcaccg ccaacaggac
3613081 gccgagctca aacaacagcg ccctcgaaac ctccaccggt tcagcccttt tcgacgatct
3613141 gttcgacccc ggcgatcccg tcctcggtgc cgatcacgat gaggacatct ccggctcgca
3613201 gcacatcagt cgggcccggc gaggccaaca catcctcgtc acgcacgatc gccacaatcg
3613261 acgcgccggt acgggtgcgc gcacgggtat cacccagcgg ccggtccaca aacaagctac
3613321 ccgcccggat gtgaatctga ccggccttaa gcccgggcac ctcacgcgtc agctcggtaa
3613381 atcgctcggc gatcctcggc gcacccagaa tctgagccac cgcctcggcc tcttcatcgg
3613441 tgagccgcaa aaccggtcgg gcttcgtccg gatcatcgcg gccatacagg acgacgtcga
3613501 aaccgccact gcgcctggca acgatgccga tccggtcacc gcgatagctg gtgaactcgt
3613561 atcgcaggcc cacccccggc agcagcacct ccttgacgtc cataggagtc aatccttgac
3613621 gaaatgcggc caagatagaa gcggtacggg caatctcgtt gactcaggta tgccggtgcg
3613681 gccacggcaa caacatcgac acctcgcggc ggtaatcgcg gtattggtcg cccagcgccg
3613741 cgagtaggtc gcgctcttcg aactgcaacg cgaccaagat gtagcccgtc gcgccgatcg
3613801 cgaaaagcaa gtgccccgcc gtcatcatgg gcgtcgccca gaacgcgacg acgaatccga
3613861 gcatgatcgg gtggcgtacc caccggtaga gcagatgagc ctgaaaaccg atctcggtgt
3613921 acggctttcc gcgccaagcc aaatacacct gccgtaggcc gaacaattcg aaatgattga
3613981 tcatgaaagt cgacgtcaac accgtggccc acccgagcca gaacaacgcc cacaacgcca
3614041 cccggccagc cggctgccgc acgtcccaga tgaccgccgg catcgttcgc cattgccagt
3614101 acagcaacaa cagcgcaacg ctggccagca gtacataggt gctgcgctcg atcgagggcg
3614161 gcacgaatcg agtccaccag cgtttgaaac cctgtcgtgc catcacgcta tgttggacgg
3614221 cgaacacgcc cagcagcacc aagttgacca cgaccgcctg gccgatcggc gccgcgatcg
3614281 cgtgatctac ggttcgtggc accactacgt cgccgacgaa accgatcgca tacccgaagg
3614341 caaccaggaa taccagatag ctcgcggccc cgtaaatgat cgtcaaataa cgcttcataa
3614401 cctgattctg ctccgcagga gtgtgcagct ggggcgttcg gcccgattgg cgccaatcag
3614461 cgattcaaca gtgccatgat gtgcggcatg gcctcgcggg ccgcaacgcg tcccgcctcg
3614521 cgggcggcgt cgatctggtg aaactccagc agcccaacag caccggtgtc gggtctgata
3614581 acgacctgcg caagactgag tgcggcatcc gccccacgct ggctgccgat tgtcatcgtg
3614641 cgcatcaagg tgtcgccgat tcctggcact tttggcgagc cgtcctgtcg agccgagccc
3614701 ggcccgccac cacctaagcc gatgctcacc gcgatcaatg ggccatcagg acttgcccgg
3614761 gtcgagaccg gaaggttgtc taacacaccg ccatccacat gcagtcgacc gttgtagacc
3614821 tggggcggat agatgcccgg cagccgaagg gaacacccaa tgacatcgac gagtcggcct
3614881 cggcggtgta cgaccggtcg gcgggcaagc aaatcgacgc taacgcaacg gaactccttt
3614941 ggcagctcct cgaccagtcg gtccccgaac gctgcttcta atagggtcag cgtccgtcga
3615001 ccacggacta gccccctgac cggaaacgcg tagtcactga gcggattgtg ccgaatgaag
3615061 tactcgtatg cgtaggcgtc cgctgttgcc gcgtccatac cgcacgctcc gaacaccgca
3615121 ataaccgccc ccatgctggt gccggcgaac cggtcgatgg tgaccccgac ccgctctagc
3615181 tcgtcaagaa ccccgaggtg cgcaaagccg cgcgcgccac cgccgccgag gactagaccg
3615241 atcgagcggc cggcgatgcg tgcggcgagc gggcgtacgt tttccaagat gcgtcggtaa
3615301 tgaaccacat gaaccgatcg cggcgtgatc aattcctccc actgacgccg gtgctcccgg
3615361 ctggcggccg gaccggccag cacgaggtcg gcaccccgcg cacgcgccgg cagccgcgcg
3615421 gcttgtgggt tgggatctcc cgcgaccagc actatccggt cggcgacgcg caggcagaag
3615481 tcccgccagc cggcatcctc gaccgcggca tgtagcacta ccttgtcggc gactcgctcc
3615541 gcgcgatcaa ggccgtcgcg gtcgacccgg ccggggtcaa cggcacgcaa ccgcgccgac
3615601 agcgcggtaa gcaggccagc ggccactgcc ggcacgggcg cgtcgccgct cactccgatc
3615661 accgaaacga ccacctcagg cgacgtcgag tcagtcgccg gtggcggtgc ctcccgcagc
3615721 cgcgttgcca gcacctttac caacgccgcc agcgcaccat ggtcggcgat ctcgtcgaac
3615781 tgtgccttgg tgagccgcac tagcttggtg tcgcgcaacg cccggaccgt cgcggaccgg
3615841 ggcgcgtcaa taagtagccc aagctccccg agaacctccc cgcgacccag ttctttgaga
3615901 acgatgctgt cctgcagcac ctgcacgcga cccgtgcgga tcacgtaaag cgaatcggac
3615961 gggtcacctt cgtggaagag atagcaaccc gcctccaact cgacgtcctc aacgtgctcc
3616021 ccgagctgtg ccaaggtggc cgcgtccagg ccggcaaata gcggcagatt ccccagcgga
3616081 tcggcgtcac cggccgccca atgctcaatc ggcgcggccg ccggctgggg aatcggtggc
3616141 tccaaccgcg gcgcgatcgc gggctccggc gccggcatct ggacggggtt gcggttggtt
3616201 ctacccagca ccgcggccgc gacagccacc gcgatgaaac agatggcagc catagcccat
3616261 ccgcgccgca acgcctcctc ggcagtaccg tgctccggct taccgatcaa gatcaccatc
3616321 accgcgacac cgagcaccgc accgagctgg cgagtggtgc taacgaccgc cgacgaggtg
3616381 gcatagctgc cgcccttggc gacctcggcc agcgctgcac tgctcaacac cggcaacgtc
3616441 gcgccgacac cgatgccctg cagcagttgg cccggcagcc acacgcggag gaaatccggc
3616501 tcggacccga cacgctgcaa ataccacacc aggctgccgg cccagaccag cgcaccaacg
3616561 aggacgatga cgcgatgccc atgccgaccg gcaacccgac ccagcgccgc cgccaccacg
3616621 gcagccacca ccgcagcggg cgcgatcgcg aaacccgcct tcagcagcga gtagtgccac
3616681 acatagttga ggtaaagcac atgggtaagg ccatagcagt aaaaacccgc tgcggcgacc
3616741 agcgtgagca ggttgcccgc cacgaacgac cggctacgca acagcgccgg ctcgaccagc
3616801 ggcgcggggt gcgaccgcga gctgtgcacg aacccaaccg aggtcaggac gctggccagg
3616861 aacgaaccga cggtggccac gctcaaccaa ccccagtccg gccccttgac caaaccgagg
3616921 gtaaccaacc cgagcgttac cgcaagcagc agcgcaccgc gcaagtcagg catgcggcgc
3616981 cggcccgagg cgcggctctc gacgagcatg cgcttggtgg cgatcgccgc gacgatgccc
3617041 agcggaacat tgaccagtaa cacccaccgc cagccggccc actccacgag gagcccgccg
3617101 atcggcgggc ccaggccagc cgcgatcgct gccgccgcac cccacaggcc gatagcgtgc
3617161 gcgcggcgcg ccgcgtcgaa gccctcaacg accagtgcga gcgaagcagg cacgagtatc
3617221 gcagccccga tgccctgcag cacccggaac gccaccaact gctcgacact gccggcgacg
3617281 gcgcacagcc cggacgcaat ggtgaacacc agcacaccgg acaggaatgt ccgtctgcgg
3617341 cccagcaaat cggccaacct gccggccgca accatgaagg cggcgaagac gatgttatag
3617401 ccgttcagaa tccaggacag gctcccgatg tcgtaggacg ggaaggaacg ctggatatcc
3617461 gggaacgcga tgttgacgat tgtcgagtcg agaaacgcca ggaaagcgcc gaaccccgct
3617521 accagcagaa ccgacgccga cgaaggtcgg cgacgacggg tgagattagc gaaccccttg
3617581 ccgccgtgca acgaaatgtg catgcgcgcc ggggcgcggg gtgtgccggg aagtgacttc
3617641 tgggaactga gaaaccgata cacccatctg caacctacgc gctaacgctt cttgaccgat
3617701 ttcggcggct tggcgccgcg gccttgtcgg cgggcggctt cgcgccgctc gcgccggcta
3617761 gcaccggccg gcactccggc cggcgtcttg tgggctccac cgccgttgcg ctgcacctga
3617821 gccgagccat cctccgcggg accggaatag gtcaaagcgg gcgactcgct ggcaacaccc
3617881 ttggcgcgta atgcacttgg agctctttcg cgcgcgccac catcgaccgc gctgcgttgc
3617941 tgcgcggcgg ctgcggccgc ggcggcgaat tcggcaagct ctgcgggttc ggcagccggg
3618001 gcaaccggcg gggcggggac cgcctccacg gtgacgttga acaggaagcc gaccgattcc
3618061 tctttcatgc cgtcgagcat ggccatgaac atgtcgtagc cctcacgctg gtactcgacc
3618121 aacggatcgc gctgcgccat cgcgcgcagc ccgataccct ccttgaggta gtccatctcg
3618181 tagaggtgtt cacgccactt acggtctatg acgttgagca gcacgttgcg ttccagctgg
3618241 cgcatcgcac cctcgccggc gatttcctcg agttcggctt cccgtgcggc ataggcacgt
3618301 tcggcgtcct tgagtagtgc ctccagcaac tcctcgcggg tgagatcgtc gcgctcgaat
3618361 tcgtggtcct tgcgggtcag cgagtcggcg gtgatcccca ccggatagag ggttttgagt
3618421 gccgtccaca acgcgtccag atcccaatct tcggcatagc cttcgccggt cgcgccgtcg
3618481 acgtaggcgg tgatgacatc gcggaccatg tccagcgcct ggtccttgag gttttcgcct
3618541 tcgaggatgc gccggcgctc ggcgtagatg accttgcgct gctggttcat cacctcgtcg
3618601 tatttgagga cgttcttgcg gacctcaaag ttctgctgct cgacctgggt ctgggcgctc
3618661 ttgatggccc gggtgaccat cttggcttcg atcggcacgt cgtcgggcag gttcagcctg
3618721 gtcaacaagg tctccaaggc cgcgccattg aagcggcgca tcagctcgtc acccagcgac
3618781 aaatagaagc gcgactcccc ggggtccccc tggcggccgg accggccacg caactggttg
3618841 tcgatccgcc gcgactcgtg gcgctcggtg cccagcacgt acaggccgcc ggcctcgatt
3618901 acttccttgg cctccttgct ggcttcctct ttgacgatgg gcagttcgga gtgccaggcc
3618961 gcctcgtact cctcgggcgt ctccaccgga tccaggccgc gttcgcgcag ccgctgatcg
3619021 gtgagaaagt cgacgttgcc gcccagcaca atgtcggtgc cgcgaccggc catgttggtg
3619081 gcgacggtga cgccgccgcg gcggcccgcc accgcgatga tggtcgcctc ttgctcgtgg
3619141 tacttggcgt tgagcacatt gtgcgggatg cgccgcttgg tgaactgccg cgacagatac
3619201 tccgagcgct ccacgctggt ggtgccgatc agcaccggct gtcccttcgc gtagcgctcg
3619261 gcgacgtcgt cgaccaccgc gatgtacttg gcctcctcgg tcttgtagat caggtcggac
3619321 tggtcttcac ggatcatcgg catgttggtc gggatgctga ccacgcccag cttgtagatc
3619381 tcgtgcagct cggccgcctc cgtctgggcg gtgccggtca tgccggcgag cttgtcgtag
3619441 agccggaagt agttctgcag cgtgatggtg gccagcgtct ggttctcggc cttgatctcg
3619501 acgtgctcct tggcctcgat ggcctggtgc atgccctcgt tgtagcggcg gccgatcagc
3619561 acccggccgg tgaactcgtc gacgatgagc acctcaccat cgcggacgat gtagtccttg
3619621 tcgcggctga acagctcttt ggccttcaga gcgttgttga gatagctgac caacggcgag
3619681 ttggcggcct cgtacaggtt gtcgatgccg agctggtctt cgacgaattc cacacccttc
3619741 tcgtgcacgc cgacggtgcg tttgcgtaga tcgacctcgt agtggacgtc cttttccatc
3619801 agcggcgcca accgggcgaa ctcggtgtac cagttggagg cgccgtcggc gggaccggag
3619861 atgatcagcg gggtgcgggc ctcgtcgatc aggatggaat cgacctcgtc gacaatggcg
3619921 taatggtgcc cgcgctgcac cagatcatcc agtgagtgcg ccatgttgtc gcgcaggtag
3619981 tcgaacccaa actcgttatt ggtgccgtag gtgatgtcgg cgttataggc cacccggcgt
3620041 tcatcgggtg tcatggtggc caaaatcacc ccgacctgaa gcccgaggaa gcggtgcacg
3620101 cggcccatcc actcactgtc gcgtttagcc aggtagtcgt tgacggtgac gatgtgcacg
3620161 ccgttgccgg ccagcgcatt gaggtaagcg ggcaacacac aggtcagggt cttgccttca
3620221 ccggtcttca tctcggcaac gttgcccagg tgcagggcgg ccgcacccat cacctgcacg
3620281 tcgaacggcc gctggtccag cacccgccag gcggcctcgc gggccacggc gaaggcctcg
3620341 ggcaacaggt cgtcgagggt ttctgggttt ttctggtcgg ccagccgccg cttgaactcg
3620401 tcggttttcg ccctcagctc ggcgtcggtg agtttctcga catcgtcgga caaagtgccg
3620461 acatagtcgg ccaccttctt gaggcgcttg accatgcgac cttcgccaag gcgcagcaac
3620521 ttcgacagca cagctatgtc cccgcatgtg taggagtctt tagataaggc gactcccatg
3620581 gtaggtgacg acgcggcgcg cgccgccgat cacgccagac ggatcaagcc gtagtcgtag
3620641 gcgtgccggc ggtagaccac cgacggccgt tcggtgtcct tgtcgtagaa caagaagaag
3620701 tcgtgtccaa ccagctccat ctggtagagc gcgtcatcga ccgacatcgg cttggccggg
3620761 tgttctttgg tgcgaacgat ccgcccaggc tcccgctcga cgacggcacc gtcgtgatcg
3620821 tgtgcctcgg ctggtctggt gttgaagccg ttctccggcg ctggcaccac cgcggtcgcc
3620881 tcggccagcg aaaccggggt tttgtcgccg tagtgcacct tgcggcgatc cttaccgcgg
3620941 cgcagccggc tctccagttt gacgaccgct gattcaagcg cggcatagaa gctgtcggcg
3621001 caggcctcac ctcgcaccac cggccctcgc ccacgcgcgg tgatctccac gcgctgacag
3621061 gacttgcgct ggcggcgatt acgttcgtgg tcgagttcga cgtcgaacag gtagatggtc
3621121 cggtcgaacc gctccaagcg ggcgagtttc tgcgaaacgt agatgcggaa gtggtcgggg
3621181 atctcgacat tacggccctt gaacacgatc tcagcgtttg atttcggttc ggccagaacc
3621241 tgacctgaat ccacggctag ccttgacata cgtgacaact cgtttctctt tccacgtcac
3621301 acgcgccctg cgtgcctggc cttcggggag acgcgccgac ggggtgggag cggttggaga
3621361 agttaccgcc gcaggctgcc cgccggagca agatgtcgat tgctcacctc ctatcgcggg
3621421 atactgattc aacctgggaa gcgcgagcgt gagtcgttaa aggttgatct cgacgttagc
3621481 ccgtgttcgg ctcaccgtgc caccaaattg accgacctgt ttcgagttct tcacgttgtc
3621541 ttggcaactg caccggctca ggcagatcct cacgcggccg cgaccgccaa cacggcaccc
3621601 acccgcacac cggcggcctg caagacccgg accgactcgc gcgccgtcgc cccggtggtg
3621661 atgatgtcgt cgacgagcac gacttcgttg cgcggccgct ggccccgcaa cagcacccga
3621721 cccgtgatgt tgcgctcgcg cgcggacgcc ccaagaccta ccgagtcccg ggctagcgct
3621781 cgcatccgca gcgccgggac gacggtgacg tcatggtggc gcccaagggt ggcacccgca
3621841 atccgcgcca tccggctgac ggggtcaccc ccacgccgtc gcgccgccca ccgtctcgtc
3621901 ggcgcaggca ccatcgtcag cgggttttcg agcatgcccc aggacaacag gtggtcgaca
3621961 ccgacaatca gcgcgcacgc cagtggcgcg acgaggtcgc gacggccgtg ctctttcata
3622021 gcgaggatcg cctgacgacg cacgcccgcg tagcggccga gcgcgaacac cggcacctgt
3622081 gggtcaacac gaggactcac cacgtgcggt tcaccggcag ccaccgacag ctcggcggca
3622141 caggcggcac accagcgggt cgccggcgca ccgcagccac cgcattccag cggcaggacg
3622201 aggtcaagca cacaccaagt gtcgcggtca ccggtgacag cagtgctgtc aatcggcgcc
3622261 gctgcgcagc ggcggccaga caaagctgag cgcaccctga ctcaattggg taatcacgct
3622321 ttccagataa cgcagcggca gctccgttcg ccactccgga agcaacgcag agagctgcaa
3622381 acaatcggct gcgaggctga cgtcggtgat gcgcagccca tgcggcagct caggcagtgg
3622441 aactcggtag gccggtgtcc gtgccggcag tgtccaccgc cgttgtccgg tgatcacggt
3622501 gcgcggtcgc agccacagtg tcgtctggga ggttgtgccc gccacgtcga cgtcgacctc
3622561 aagacctccc cagtcgggcc ggcgcgccca gcgcagccgg gccgctccgc tctcggacaa
3622621 ctcaccgcgc agctgcggcg tcgcttgacg gagcacatca tcgaaaatct cggtcggcag
3622681 ggcggacgac aactcgacgg gagcggcgat caccagcggc ggcacacccg ggcggatgtg
3622741 cacgttgcgc aggacggcaa cggcgctgtg caaatgatgc tgatcccagc tgatgccgcg
3622801 agcggccacc cgaacctcgc ccagctggcc gacggccagc ccctgcggtt ccagtgccga
3622861 gtccagctcg gtgacggtca gcaccacgtc atggtcccca atccgaaccg tgacttcctt
3622921 gccgatgagc agctgctgca aggtggtgaa caacgtccgg tagggcgccg caactgcctg
3622981 ggcggctccc gcgctgacca gcgacatccc ggtcgacgac cacagcgagg ccagcatgtc
3623041 caaggcacgg aagggatcat cccaacgcag ccggggaact cttggcgaca tcaacaagcg
3623101 cctcctcact gcgagggtag ccggtgtgct caggtcgcga aaaacgcagg cacagcactc
3623161 atccgggcaa taccggcgcc gcccccggca ccatcagccc cggtacgtcc gcccagcctg
3623221 gtcggctttc gacagacgcc gagtacatca acaccccttg cgggccggcg acatacacag
3623281 tcgacgggtt ggccgcgatc gccgtcagtg gagtttgcaa cccgcgggac ggcgcgtcgg
3623341 agttcacccc gtcgaggttt acataagaca ccggatgggc ggcgtcggtg cgtgtcacca
3623401 cgatgtcgtc accggttcgc caggacaacg acaccaccga ggaacccagc ccgaaaccca
3623461 gccgccgagg gtaggtcagg gcgaactggc cagcctgggt ctgctcgacg ccggcgagga
3623521 tcacctgccc accgatcacc atcgcggcgc gcgtcccgtc acgggacagt tgaagatcgt
3623581 tgatcgcccc cgggaagcgg ctggccaccg cggtcgaatc caccggaatc cgcgcgggtt
3623641 gccccgatgc cgggtcctgt atcgctcgca gcacgacgtt ggtatcgacc accacccaga
3623701 ccgcgtcgtc cagcgaccag ctgggccgcg acaggctgtg cccgtcggcg gactgcaccg
3623761 cctcgccgcc gaggtcgccg acccacaaag acgccgcctc atccggagcc ccgcgcccca
3623821 gcgtcaccac cgaggccacc tgacgcccgc tgcgtgatac ggcggccgcc gtctgctccg
3623881 gcatccgtcc gaaggccccg ggcacggggg tgactcgctg tgcgtccatc gccaccagtg
3623941 atccgttcac caaggcgtgc aaccccgcgg cggcaccgtc ggccaccccc gggtcggtgg
3624001 ccgcgacatc ggaagtggtc cacccctcgg caaacctgtc ttccagcggg gcgccgtcgg
3624061 cgttgatcac gtacggcccc ctgatgtcgg ccctggccaa ggtccagatg atctgtgcgg
3624121 caagtaattg cctgctgtgc ggatcggtgg tggacagctt ctccatgtcg actcgcgcgc
3624181 cgccgtaccc gcggccgatt ccgctctttc cgccgtcggc ccgagtcacc ggcccgcgca
3624241 gtcgtagcgg cggagcgagc agattacgca ccgtgcgcgc catctccggg cgtggacccg
3624301 ccagcagttt ggagacgagc tccgtggcca gctggtcgcg gtcggacacc gcgacgtagc
3624361 gcggatcggg aaccacggtc ttgccggtgg ggtcggcgaa gtacagggtg ttgcgcttgt
3624421 acgtttcttg gaactgctgc cagtccagga aaaccccgtt gggtaggcga tcgatgcgcc
3624481 aaccatcgga cgtcttgacc aactcgatcg ggcccggatc cggcagttga ccctcggcgg
3624541 tctcaaacac ccccacatcc gagagcgagc cgagaatgtc tgcccgcatg gtcaccgaaa
3624601 ccttctcggc gcttcgggtt tcgacgaaca ccacgtggtc gatcaacaac gcgctgccgg
3624661 cgtcgtccca ggcgttggaa gccgattcgg tgaggaactg acgcgccgcc aggtgccggt
3624721 tggccgggtc ggctgtggcc ttgaggaact cgcgtaacag cacgtcggga tccatacccg
3624781 ggctcggttt gggcagattc gacggcaccg gacgttcgac ggttccgatg gcttgcgggg
3624841 ccgacgtgct gggcacactg gcacagccgg ccagcactgc accaaggaac aacaaaattg
3624901 tcagccgcat caaccgctcc actccgcgtg ctcacgtggg cgctgacgtt ccttgtattc
3624961 cggtggcatc ggttgcggat tcggttgcgc gaccggttgc agaactggct gcgggatcgg
3625021 tttcatgggc agcgggctgg tggtgacctt gtggccgcgc accatcggaa gcgtcagccg
3625081 gaagcaggcg ccctcgccgg gttcgcccca cgcctcaagc cgaccctggt gcaatcgggc
3625141 atcctcgacg ctgatcgcca aacccagccc ggtgccgccg gaccgacgta cccgtgaggg
3625201 atccgagcgc cagaaccggc taaacaccag cttctcctca ccaggccgca gcccaacccc
3625261 gtagtcacgc acggtgacgg cgaccgtgtc ttcgtcggcg gccatccgga tccgcaccgg
3625321 tttgtgttcg gcgtggtcga tggcattggc aatcagattg cgcaggatcc gttctacccg
3625381 acgcgcatcg acctccgcga tcacctgctc ggcgggcaga tccaccagca actcgatacc
3625441 ggcctcctcg gccaggtggc ccacattgcc gagcgcgttg ttgaccgttg tgcgcaagtc
3625501 gaccgcctca accgacaact cggccacccc ggcgtcatgc cgcgagatct ccagcaggtc
3625561 gttgagcaac gtctcgaatc ggtccagctc gctaaccatc aactcggtgg accgccgcag
3625621 cgtggggtcg aggtcggcgc tgtggtcata gatcaagtcg gccgccatcc gcaccgtggt
3625681 cagcggcgta cgcagttcgt ggctgacgtc ggaggtgaac cggcgctgta ggttgccgaa
3625741 ctcctccagc tgggcgatct gtcgggacag gctctcggcc atgtcgttga acgacaccgc
3625801 cagcctggcc atgtcgtcct cgccgcgcac cggcatgcgt tcggacagat gtccctcggc
3625861 gaaacgttcg gcgatccgcg acgccgaccg caccggcacc accacctgac gcgacaccag
3625921 cagcgcaatg ccggcgagca ggactagcag taccaggccg ccggtggcca tcgtgccacg
3625981 caccagcgtg atcgtggctt gctcgctcgc cagcggaaag atcaggtata gctccaggtt
3626041 ggccacccgc gacaacgtcg gagtcccgat gatcagggcc ggcccggaga aaccttcggt
3626101 ctgcaccgtg gcgtactggt aggcggcctg cccggccttg acgaagccgc gcagcgcgtt
3626161 gggcacctga tcgacgggtc cggcagtaga ggcagcgcgc ggcccatcac ccggcaccat
3626221 cagcaccgca tcgaacgcac cggcgaggcc agcccccgaa gcggggtcgg ttttcgacgt
3626281 cagagtgttg cgcgcaagct gcaggctact gtccagtgag cgcgtctcct caccgttgac
3626341 gatcccgctg acggtggtgc gtgcccgctc gatctggtcg atcgccgccc tgaccttgat
3626401 gtcgaggaca cgattggtga cctggctggt cagcacaaag ccaagcgcca ggatgacggc
3626461 tagcgacagt ccaagggtca gcgccacgac ccgcagctgc agcgatcggc gccacgcgac
3626521 agctacggct cgactcaacg cactgaggcc ccgtgtcatc gggccagagc gaccccggcg
3626581 accccgaatg cgtcggcgcg agccgaagat catcggcgcc gctccttagc atcgctgcgc
3626641 tctgcatcgt cgccggcgcg gatcacggag gtccggcctt gtaccccact cctcgaacgg
3626701 tcagcaccac agtcgggttc tcgggatcct tttcgacctt ggcccgcaga cgctggacat
3626761 gcacgttcac cagcctggta tcggctgggt gccggtaacc ccatacctgt tcgagcagca
3626821 catcacgagt aaacacctgg cgcggcttgc gcgccaatgc gaccaacagg tcgaattcca
3626881 gcggtgtcaa cgagatctgc tcaccgttgc gagtgacctt gtgcgccggt acgtcgattt
3626941 ctacgtcggc gatggacagc atctcggcgg gttcgtcgtc gttgcggcgc agccgcgccc
3627001 gcacccgcgc aaccagctcc ttgggcttga acggcttcat gatgtagtcg tcggcgcccg
3627061 actccagacc cagcaccaca tccacggtgt cggtctttgc ggtgagcatc acgatcggaa
3627121 caccggaatc ggcgcgcaac acccggcaca cgtcgatgcc gttcataccg ggcagcatca
3627181 aatccaataa caccagatcg gggcgcagct cgcgcaccgc ggtcagagcc tgagtaccgt
3627241 cgccgatgac cgcggtgtcg aagccttccc cccgcagcac gatggtgagc atctcagcca
3627301 acgaagcgtc gtcgtcaacg accaaaatcc tttgcctcat ggtgtccatg gtgtcaccac
3627361 atcgggacaa aactggcgca ccacacgggc gtttcttgct tgattagggc aaataccctc
3627421 aacttggcac gtctggaggc gccaaagtcg ccgctagtcg gcccggatca acatcggcgc
3627481 cgacaaccag ccaccggccg ccccaccctt gggccgccaa ctcggcgtag accgcaccgg
3627541 tgcgctgctg aagttcagcg tcgcgttcgt aattgtcgcg cgcccgaccg gggtcacgct
3627601 gggcacggcc gcgggatcgt tccccggcga gctcggcaga gaccgcaagg agcacctgcc
3627661 agtcgggctt gggcaacccg agtcttgcaa attcgatccg ctgaacccag gccgctgcct
3627721 tcccggccgc gttttcatgt aggcgcgccg cgctgtaggc cgcgttggag gcgacgtagc
3627781 gatccaggat caccacgtcg tagccgcgac acagcccctg gatcgtgtgg accgcgccag
3627841 cgcggtcgag cgcgaacagc gtcgccatcg catacaccga cgatgcgagg tcaccgtgct
3627901 cgccgtgcag cgcctccgct gcgatgtcgg cggccaccga ctgtccgtag cgcgggaacg
3627961 ccagtgtggc caccgatctc ccggctgctc gaaaggcccc ggacagcttt tccaccaacg
3628021 tccgcttgcc agcgccgtca acgccctcaa tcgcgattag cacggcgcgg ccctgtcggt
3628081 ggcggcgcga gcagacgcaa aatcgccctt ttcgtcatga aaatgggcga ttttgcgtct
3628141 gctcgcgggt gggaggcact cagtagcggt agtggtccgg cttgtaggga ccctcgacgt
3628201 cgacgccgag gtattcggcc tgctccttgg tcagcttggt caggtgaccg ccaagggcct
3628261 cgacatggat tcgagccacc ttctcgtcga ggtgcttggg cagccggtac acctcgttgt
3628321 cgtactcgtc gttcttggtc cacagctcga tctgggcgat cgtctggtta gcgaagctgt
3628381 tgctcatcac gaacgagggg tgcccggtgg cattgcccag gttcagcagc cgcccctcgg
3628441 acagcacgat gatcgagcgg cccgtgtcgc caaaggtcca caggtcgacc tgaggcttga
3628501 cgttgacccg tgtcgccccg gagcgctcca gcccggccat gtcgatctcg ttgtcgaagt
3628561 ggccgatatt tcccaggatc gcgtggtcct tcatcgcctt aatgtgctcg agcatgatga
3628621 tgtctttgtt gccggtcgcg gttacgacga tgtcggcgtc cccgatggcc tcctcgacgg
3628681 tgaccacgtc gaagccctcc atcatggcct gcagcgcgtt gatcgggtcg atctcggtga
3628741 cggagacccg cgctccctgg cccttcatcg cctccgcaca gcccttaccg acgtcgccgt
3628801 agccgcagat gaggaccttc ttaccgccga tcagcgcgtc ggtgccgcgg ttgatgccgt
3628861 cgatcaggga gtgccgagtg ccgtacttgt tgtcgaattt ggacttggtc accgagtcgt
3628921 tgacgttgat cgccgggaag gccagatccc cggccgcggc gaattggtag agccgcagca
3628981 cgccggtggt ggtctcctcg gtgacgccct tgaccgactc ggctatcttg gtccacttgt
3629041 ccttgtcggt ctcgaagcgg gtccgtagca ggttcaggaa gaccttccac tcggcggggt
3629101 cgtcctcctc ggcgggcggc accacgccgg ccttctcata ctgcatgccg cgcagcacca
3629161 acatggtggc gtcaccgccg tcatcgagga tcatgttggc cggcttgtcg gggtccggcc
3629221 aggtgagcat ctgctcggcg gcccaccagt actcttcgag cgtctcgccc ttccacgcga
3629281 acaccgggac acccttgggc tcgtcggggg tgccgtgcgg gccgaccacg acggcggcgg
3629341 cggcgtgatc ctgggtggag aagatgttgc acgaggccca gcggacttcg gcgcccagcg
3629401 cggtgagggt ttcgatcaac accgcggtct gcaccgtcat gtgcagcgaa cccgagatcc
3629461 gggccccctt caggggttgc acctcggcat actcgcgccg cagcgacatc aggccgggca
3629521 tctcgtgctc ggcgatccgg agttctttgc ggccgaaatc cgctagtgac aggtcggcga
3629581 tcttaaagtc gatgccgtta cgaacgtcag gggtcagcga atttttggtc accaaatttc
3629641 cggtcatagg ggctttcatc cttctttggg ggctcacagg gatccgagcg ggctacttag
3629701 cctaggtacg ctcttgcagt cactgtagcc gccgtcggtc agccccgcag gtcaggggac
3629761 attgatcaca ccgtgacgct ccgcgaacgg cgttattagc cgtgctaggt ccgctgcgac
3629821 atcatggtcg gcctcgggcg gcatcgacac gtagctcaag cacagccgca cgatcgcacg
3629881 cgagagcaca ttggcgtcgt tatcggtggt ggccacccag gtatcggtga aggccggcgc
3629941 cagccgggcc gacgcgcggg tgatgatcgg cgcgctgtcg gtggtgatca gttgcagcag
3630001 atcgggcttg gcgacaccgg tcaacagcga gatgaccaac ggatctgccg ccgactcggc
3630061 gaagaacgac cgaaagccct gcaggaacgc ttcgtaaaag ttgccgacgt tggcgtccaa
3630121 cgatgcatgg acgttgtcca ctaatcggtc ggccaggcgc agcgcgtatc cctgcgccag
3630181 gccttgccgg gaaccgaatt cgttgtagat ggtctgccgg ctgatgcccg ccgcgcgggc
3630241 cacgtcggac agcgtgatgg cggaccagtc gcgggtcagc agcagatccc gcatcgcatc
3630301 cagcaccgaa tcccgcaaca gggcccgcga ggcctcggca tagggtatcc gcttcacagg
3630361 cgcgacagta gcgcttggag tgctcacgag cgagccacct ccaccatctc gaaatccgac
3630421 tttgccgcac cgcaatccgg gcaactccag tcatcgggga tgtcgtccca gcgggtgccg
3630481 gccgcgatgc cgtcctccgg ccaacccagc gcctcatcgt actcaaagcc gcattggata
3630541 cagcggaaca gtttgtagtc gttcacttag ttaccctcct atcttttcga aatcgacctt
3630601 ctcgcgcacc gcgcagtccg ggcagcacca gtcgtcggga atttgatccc agcctgtgcc
3630661 ggctgggaag ccttccctgg catcaccgtt ggcctcgtcg tagacgtagt cgcagaccgg
3630721 gcaccggtag gcggccatca tgccgaggct ccgtaacggg cgagtgcctt ctcccgcacg
3630781 cgcgggtgca ggttaacccg agtgatatcg ccgccgtagt gctccagcac ccggtgatcc
3630841 attaccttgc gccacaacgg cgggaagtag gtcagcgaga tcatcgatgc atacccactg
3630901 ggcaggttgg gcgcacccgc catgctccgc agtgtctgat agcggcgagt ggggttggcg
3630961 tggtgatcgc tgtgtcgctg caggtggtag aggaacaggt tggtgacgat gtggtcggag
3631021 ttccagctgt gcaccggggc gcagcgctcg tagcggccgt tggcgctctt ctgccgtagc
3631081 agtccgtagt gttcgaggta gttgacggcc tctaacaggc tgaagccgaa gactgcctgg
3631141 atgatgacga acgggatcag cgccgggccg aagaccgcga tcagcccacc ccacaacacc
3631201 accgacatca gccacgcgtt gagcacgtcg ttgcgcagat acgtcatggg attccagggg
3631261 ctgacgccga gccgacgcag ccgttgggcc tccaaatgaa cggccgagcg caagccgccg
3631321 ataacactgc ggggcaggaa ctcccacaac gtctcgccga accgcgccga cgccgggtcc
3631381 tccggtgtgg acacccggac gtgatggcca cggttgtgct cgatgtagaa gtgcccgtag
3631441 caggtctggg cgagggtgat cttggacagc caccgctcca gcgaatcctt cttgtgcccc
3631501 atttcgtggg cggtgttgat accgacgccg ccaagcacac cgaccgacag cgccacccca
3631561 agcttgcccg cccagctcaa ggcgccgtca aagccgagcc aactgaggtt tgcggcggtg
3631621 aacaggtatg cgcccagcac cacgctgagg tactggaacg ggatgtagat gtaggtgcag
3631681 tagcggtagt acttgtcatt ctccagccgg tcggtcacct cgtcgggcgg gttctgcccg
3631741 tcgggcccga agcgtaggtc aagaagcggc aacaagacgt agagcaggat cggtccgatc
3631801 cacagcggca cctgcgcggc ggcgtgccag ccgagctggt tcatccccca gatcagcggc
3631861 agcatcacca ccaaggccgt cggggcgatg aggcccataa gccacaggta acgcttcttg
3631921 tcccgccact cctcgacttc gggcggccgg ggggcttcgg gtccaccaga gccgatttgc
3631981 gtggtcatat gccaaacctc ctcatgagcc acaccacgtt gggatttgac aatagagcag
3632041 tttgcgtctt atgtctagac atataacgca atttgtaaat acgcggcgaa gctagttcaa
3632101 cacctccggg tcgcgctctc tcgagcttgc cgaaggccct gcgccgagtg ccggcgcccg
3632161 tagccgacat aaatcgcggt tccggccacc agccagatcc cgaaccggat ccaagtcaac
3632221 gcggtgaggt tcagcatcag ccacaggcac gcgcacactg cggcgatcgg aagtaacggc
3632281 acccacggag ctgtgaaccc ccgctgaagg tcgggtcggg tccggcgcag cacgaccact
3632341 ccggccgaga cgaggatgaa cgcgaacagt gtcccgacgt tgaccatctc ctcaagcttg
3632401 gtgatcggaa acaccgacgc cgtcgtggcc accaacaccg cgaccagcac cgtgacccgg
3632461 accggggtgc cgcgcgaacc ggtcttggcc aattgccgcg gcaccaagcc gtcgcgcgcc
3632521 atggcgaaca gcacgcggca ttgcccgagc atcaacacca tcaccaccgt ggtaagcccg
3632581 gccagcgcgc cgacggagat gatgccgctg gcccagtaca ccccgttggc ctggaacgcg
3632641 gtggccagat ttgccggccc gcggcccggt acggtccgca gttgggtgta tggaaccatg
3632701 cccgacagca ccaccgatac cgcgacgtag agaagggtca cgacccccag cgacgcgaga
3632761 atccctcgag ggacgtctcg ttgaggacgc ttggtctcct cggccatggt ggccacgatg
3632821 tcaaacccga taaacgcgaa gaacacgatc gatgccccgg ccagcacgcc gtaccatccg
3632881 tagtggctgc cttgggctcc ggtcagcaac gagaagacgg attgatcgag cccgccgccg
3632941 tggtgctgga cttcgggctc gggaatgaac ggcgagtagt tggcggccct gatgtagaag
3633001 gcaccgacga ccaccaccaa gacgaccacc gacaccttga ttgcggtgac caccgcggaa
3633061 aatctcgacg acaatttggt gcccaacgcg atcagggtcg ccaccaacgt gacgatcacg
3633121 agcgcacccc agtcgagctg cagcgatccg agatggcctg tgccattacc gaatccgaac
3633181 acggtgccca agtagctgga ccagcctttg gcgaccacgg ccgcacccat cgccagttcc
3633241 agcaccagat tccagccgat cacccaggcc aagaactccc cgaaggtggc ataagagaag
3633301 gtataggcgc tgccggccac cggcagcgtc gaggcgaact cggcgtagca cagcgcggcc
3633361 agcgcacagg tcgccgccgc gatcagaaac gatatccaga tggccgggcc ggtgatatcg
3633421 ccagcggtcg acgcggtaac cgtgaatatt ccggcgccaa tcaccaccga gacgccgaaa
3633481 acaaccaggt cccaccaggt gaggtccttg cgcagccgag tggtgggctc gtcggtgtcg
3633541 gcgattgact gttctaccga cttcatgcgc cgtcgaccgg ccatgcaccc gtcctctcgc
3633601 actcgttgtg accgcacagt actgggtact ctgcgaggat gacgggtcgc gtagggaacc
3633661 cgaaggacca cgccgtggtg atcggagcta gcatcgccgg gttgtgcgcc gcgcgggtgc
3633721 tctcggactt ctactccacg gtgacggttt tcgagcgcga cgagttgccg gaagcgccgg
3633781 cgaaccgggc cacggtccct caagaccgac acctgcacat gttgatggcc cgcggggcgc
3633841 aggaattcga cagcctgttc cccggcctgt tgcacgacat ggtggccgcg ggcgtgccca
3633901 tgcttgagaa ccggccggac tgtatctact tgggcgccgc cggccatgtc ctcgggacgg
3633961 ggcataccct gcgcaaggag ttcaccgcct acgtgcccag ccggccgcac ctggaatggc
3634021 agctgcggcg acgggtcctg cagctctcca acgtccagat tgtgcggcgc ctggtcaccg
3634081 agccacagtt cgagcgcagg cagcagcgag tggtcggcgt gctgctggat tcccctggta
3634141 gcggccaaga tcgggaacgc gaagagttca tagctgccga ccttgtcgtc gacgcagccg
3634201 gccggggtac ccgactgccg gtttggttga cgcagtgggg atatcggcgg ccggccgaag
3634261 acaccgtgga catcggcatc agctatgcca gccaccaatt tcgcattccc gacgggctga
3634321 tcgccgagaa ggtggtggtc gccggcgcct cacacgatca gtcgctgggg ctaggcatgc
3634381 tgtgctacga ggacggcacc tgggtcctca ccaccttcgg ggtggccgat gccaaaccgc
3634441 cgccgacttt cgacgagatg cgtgcactcg cggacaaact gctgccggcc cgcttcaccg
3634501 ccgcgctggc gcaagcccaa ccgatcggct gtccggcgtt tcatgctttc ccagccagca
3634561 gatggcgtcg ctacgacaag ctggaacgtt tcccgcgcgg aatcgtcccg ttcggcgatg
3634621 cggtggccag cttcaatccc accttcgggc agggcatgac gatgacctca ctgcaagccg
3634681 gccacctacg acgggcgctc aaagcccgca actcagctat gaaaggcgac ctggccgccg
3634741 aactcaatcg ggccaccgcc aagaccacct atccggtgtg gatgatgaac gcaatcggcg
3634801 acatcagttt ccaccacgcc accgctgagc cccttccccg atggtggcgc ccagccggtt
3634861 cgctgttcga ccaattcctc ggggccgcag aaaccgatcc tgttctcgcc gaatggtttc
3634921 tgcgacggtt ttcgctgctg gacagcctgt acatggtgcc gtcggtaccg atcatcggtc
3634981 gcgccattgc tcacaatctg cgattgtggc taaaagagca gcgtgagcgt cggcaacccg
3635041 tcacaacccg acggtcgccc tgaacagctt ggcgggttgg ccggcggtca gccggatcgg
3635101 gccgtcgtcg gccgccaccc aggcggccgt gccgcgctgt agcgtgagcg acccgcactt
3635161 cccgtgcacc gtcgccgaac cctcggtgca taacaagatc tgtggaccgt catggccgga
3635221 cgacgcgtcg acctcgtggc cgaggtgatc gccgtcgagc accagtagcg tggccgcgaa
3635281 ctcatcggtg ggcgtctcaa agaccagccc cagcccctcg cgccggatcg ggggccgcag
3635341 ccgagccttc ggcgtggggg cgaagtccag cacccgcaac aactcgggca catcgacgtg
3635401 cttaggggta agtccaccgc gtaacacgtt gtcggagttg gccatcactt ccacaccgaa
3635461 accacgcaca taggcgtgca ggttgccggc cggcaggaag atcgcctccc caggagccaa
3635521 gctgatgcgg ttgagcaaca acgccgccag cacaccggcg tcgccgggat aacgttcgcc
3635581 gagttccagc actgtcttgg cttcggcgcc aaattccgtt gcgccggagc tgacgtactg
3635641 gatagcgccg tccagcacgg caggcaccag cacgtcgatg tcgggctggg gtgcggtaat
3635701 ccaggtggtg aacagcgcac gcaaaccatc ggcatcggac ccctcgctca gcaagtcgat
3635761 gaacgggtcg aggtcggata cggccagcgc ccgcagcagc tcggtggtgc gagccgcctc
3635821 ccggaatccg gccagcgcct cgaacggctg cagcgccacc aataactctg gcttgtgact
3635881 ggtgtcgcgg tagttgcgga cgggtgagga caccggaatg cccattcgct cttcccgcag
3635941 gtagccctca accgcctgct cggcgctcgg atgggcctgc aacgatagtg gctcgtcggc
3636001 cgccaacacc ttgaccaaga acggcaacac atcgccgaat cgcgcgcgcg acgcggagcc
3636061 gagctgcccc tccggatccg cgaccaacgc ttcgagcaac gaggtttggc catgcggcgt
3636121 ctgcagccaa gccggatcac ccgggtgtgc accgaaccat agttcggcct cggggtgagc
3636181 ggccggcacc ggacgcccgg tgaattcggc gatagcggtg cgcgatcccc aagcgtaggt
3636241 gcgtaacgcg ccacgtagca gttccaccgg cgatctatcc tcgcaccagt cgcagataca
3636301 cggcggccat ctccagccga acggccaata ccgccccccc ggatcccacg ggggcgtcga
3636361 gcagctccgg cacatcctca gccgcgacca gataggcgtc atcgagcccg gcaacccgag
3636421 cggccaccac cgtccgctcg ccggccagcg ccagcgccaa cacccgcagc cgctgcggtg
3636481 ccggcccatc gatttcctcg tcatggaaca gcgcatccgg cggcgtcccg gcacgtagcg
3636541 ccacaaccgc atccgaaagc ctggtagcgg ccacaacctg gtttgcgatc cgcagcatga
3636601 ccgaactccc atgccgggcc agcgccagcg tcgcggcatt gtctccagcc agggccagct
3636661 ggcaaccgga aacgcgagcg gcaagtgcct tggccgggtt ggtgaacacc tctcggccgg
3636721 cgctgttgcg gagcgcctca gcatccagct cgtctgccag cgacgccaga tcgatgcgca
3636781 gcttgggatc cacggtttgc aaggccgcca gacccgcggc caggtaccgg gacaacccga
3636841 actcgtcagg aacccgcagc cgcggttcca gcaccgcgac gcgaccggcc gtgctgtccc
3636901 gcagcggacc ctcatacggt gccaccacga caacccgcgc gcccctgcgc accccgatcg
3636961 cggcggcccc gaccagcgcc gggtcgccgg ggtcgtcgcc ggcaacgatc agcacgtcaa
3637021 gcggcccgac ccagggcggc gccgcactgg cgagcacgat cggctcggcg gccccggcac
3637081 ctagcgtcga ggccaggatg gtcccggcgg tctcagcggt cccccggccg gtcacccaga
3637141 tcaccgagcg gggacggtca ctaccgcgca gcaagtccag ttcgccctcg tcggccgcgg
3637201 cagcgatggc acgcacctgt gcgccggcca tcgatgcggc ccgcagcagg gcaccccggt
3637261 cggcagcgat caggccttcg gtgtcctcga gatcgatcgc ccgggcgacg ttcacggtcc
3637321 ggccttcgca tgtgcgctct gggcagcgat ttcagcgctg acctgacgta ccaccgcgtc
3637381 aacgtccccg acgctgcggc cctccacatt gagccgcagc aacggctcgg tgtttgagct
3637441 gcgcaggttg aaccagctgt cgtcgcctaa gtcaacggtc acgccatcga ggtgatcaat
3637501 actgacaatc cggttgccga acgatttcaa cacggcctcc acacaggccg aagagtcgac
3637561 cacggtgaag ttgatctcgc cggaggattc atagcgttgg tagtccgcgg tcaactccga
3637621 cagcggtctg ctctgctcac cgagggcggc cagcacatgc agtgcggcca gcattccgga
3637681 atcggcaccc cagaagtcac ggaagtaata gtgcgccgaa tgttcaccac cgaaaatcgc
3637741 cccggtctcg gccatcagtg ccttgatata ggagtgccca acccgcgaac gcagcggcgt
3637801 accgccgcgc tcggcgacca gctcgggcac cgcgcgggag gtgatcacgt tgtggatgat
3637861 ggtggcgccg atctcccggt tgagttcccg cgcggccacc aatgcggtaa ccgtcgacgg
3637921 cgagaccggc tggccgcgtt cgtcgaccac gaagcagcgg tcggcgtcgc cgtcgaaagc
3637981 aagcccgata tcggcgccgg tgtcacgcac ataggcctgc agatccacca ggttcgccgg
3638041 gtccagcgga ttggcctcgt gattgggaaa cgatccgtcg agctcaaaat acgagggcaa
3638101 caaggtgatc gagtcgatca ccccaaggac cgccggcgcg gtgtgaccgg ccatgccgtt
3638161 gccggcgtcc acggccaccc gcaacggacg tagccccgag gtgtccacca gcgatcgcag
3638221 gaacgccccg tagtcgacca gcacgtcctg gtcggcaatg gttccgggcg tcccgtcgta
3638281 tcgtgcgacg ccggcgatca ggtcgtcacg gatggcggtc agcccggtat cggctccgac
3638341 tggtttggcg gcggcccgac acatcttgat gccgttgtat gccgccgggt tgtggctcgc
3638401 ggtgaacatc gctcccgggc agtccaacag ccccgaggcg aaataaagct gatcggtgga
3638461 cgccaaacca actcgcacca cgtcgaggcc ctgcccggtc accccggccg cgaacgcgtc
3638521 ggccagcgac ggcgaactgt cccgcatgtc gtgaccgatc accactggtc gcgcatcctc
3638581 ggtccgcatc aaccgcgcga atgcggcgcc gagatcggta accagcgact cgtcgatctc
3638641 ttcgccgacc agcccgcgta cgtcgtaagc cttgataacg cggtccacag ccgcggcggg
3638701 ccaagacatg cgcgggctcc tgacaaccta gattttctgc gactcttggc cgccagccta
3638761 tcggcccgcg aacgacgcgg gccgaatcgg tctcgaacag catgggaaga ctagtcggcg
3638821 gggtcgggca acacccgtag atgtccgcgc cggcgcccgg ccccaggctc gggcggcgca
3638881 agcacgccac ccccggtggg cgctccggtc gccgcagcgg gaaaatcgtc gaaaccatgc
3638941 agtggcgcgc catttccgcc tggatgatgc cggcgccccg cgctcgggcc accctcgcgc
3639001 accgcgtccg ccagggccac caggtcgtcc tcgtcggggt ggctgggcag cggcccggcg
3639061 tgacgcacga gttcccaccc gcgcggtgca gtgatgcgac cggcatggcc gacacacaga
3639121 tcccacgaat ggggctcccg cgcagtggca agcggaccga tcaccgccgt cgagtccgag
3639181 tagacgaacg tcaacgtcgc cactgcatag tgcggacacc cgggccggca gcagcgacgg
3639241 ggtacgttca cgaccgaaag gctatcgtgc accaacgccg ccgaagcgcc ggacacgcgc
3639301 atccgtccac gccgcgatgt ttaaccgtta ccatcggcgc gtgagcgatt cccgcagctc
3639361 ctcgtggagc cgtcggtcgc ggggcgggtc ggtagcgcgg cgagcaatcc ggcggggccg
3639421 cgagatgcgc gggccactgc tgccgccgac agtcccgggg tggcgcagcc gggccgagcg
3639481 gttcgacatg gcagtgctgg aagcctacga acccatcgag cgacgctggc aggagcgggt
3639541 gtcgcagctg gacatcgcgg tcgacgagat cccgaggatc gcagccaaag atcccgaaag
3639601 tgtgcagtgg ccgccggaag tcatcgccga cggaccgatc gcgctggccc ggctcatccc
3639661 ggccggcgtg gacgtccgcg gaaatgcgac gcgcgcgcga atcgtcttgt ttcgcaaacc
3639721 aattgaacga cgggccaagg acaccgagga acttggtgaa ttgctgcacg aaatcctggt
3639781 ggcccaggtg gccatctacc tggacgtcga cccatccgtc atcgacccga cgatcgacga
3639841 ctagttcgcg ccgccgactc cggcggccgg gtcagatgat cccgcgtttg aggcggcggc
3639901 gctcgcgttc ggaaagacca ccccagatgc cgaaccgctc gtcatgagcc agggcgtact
3639961 ccagacactc gtgccgcacc tcgcagccca tgcaaatctt cttggcctca cgcgtggagc
3640021 cgcccttctc cgggaagaac gcttcgggat ccgtttgcgc acatagcgca cggtcctgcc
3640081 attggtcggt ggcttccggc ggcagaggtt cctcgaatgg cgccggcgcc tcgggaacca
3640141 aactcagatg cggtcgcaaa actgccgttg ctgatgcggt agccgatccg gtagtggtat
3640201 gcggtgtgcc tcccattaca ccccgaaggt gttcatagga catgcctccg cctcctcact
3640261 cgatagatag tgaaatggtt tcccactgtt ttgatgtaca gttaacccaa ttcgaacaag
3640321 tgatcgaatc tcggtctgcg acaccgaaac cggccggcca accgcgaaat gacactgatg
3640381 tgattagaca caagttgggg acgcgggtca agtgtgccgg cgcatttcca tatcatctcg
3640441 taataaaatt tccgcggttc tgttgtggtt gggtcccggc gtgtcgagcg tgactcgtaa
3640501 ccaacgtttg gtgatgggcg ccgggaggta ctgtcctgcg atgtgaaggt caccgttctg
3640561 gccggtggag tcggcggcgc ccgcttcctg ctcggggtcc agcagctgct cggcctgggc
3640621 cagtttgctg ccaattctgc ccactcggac gccgaccacc aactgagcgc tgtcgtcaac
3640681 gtcggcgacg acgcctggat ccacgggctg cgtgtctgcc cggatctgga cacctgcatg
3640741 tataccctgg gcggcggggt ggacccccag cgcggctggg gccagcgtga cgaaacttgg
3640801 cacgccatgc aggaactggt gcgctatggc gtgcagcccg actggttcga gctcggggac
3640861 cgcgatctgg ccacccatct ggtgcgcacc cagatgctgc aggccggcta ccccctgtca
3640921 cagatcaccg aggccctatg cgatcgctgg caaccgggcg cccgcttgct gcctgccacc
3640981 gacgaccgtt gcgaaaccca tgtagtgatc accgacccgg tcgacgaaag ccgcaaggcg
3641041 atccattttc aggagtggtg ggtgcgctac cgtgcccagg tgccgacgca cagctttgct
3641101 tttgtcggcg ctgaaaagtc cagcgctgca accgaagcga tcgccgccct ggccgacgcc
3641161 gacatcatca tgctggcgcc gtctaatccg gtggtcagca tcggcgccat cctggccgtc
3641221 cccgggattc gcgcggcgtt gcgggaagca accgcaccga tcgtcggcta ctcgccgatc
3641281 atcggcgaaa agccgttgcg cggcatggcc gatacgtgcc tttcggttat cggggtggat
3641341 tccaccgcgg ccgctgtggg ccggcactac ggcgcgcggt gcgccaccgg gatactggac
3641401 tgctggctgg tgcacgacgg cgaccacgct gagattgacg gggtgacggt gcggtcggtg
3641461 ccgctgctga tgaccgaccc gaacgcgacg gctgagatgg ttcgcgccgg gtgcgacctt
3641521 gcgggagtgg tagcttgacc ggccccgaac atggctccgc ctcgaccatc gagatcctgc
3641581 ccgtcatcgg gctgcccgaa ttccgtcccg gcgacgatct gagcgccgcc gtcgccgcgg
3641641 cggcaccgtg gctacgcgac ggtgacgtcg tggtggttac cagcaaggtg gtgtccaaat
3641701 gcgagggccg gctggttccg gctcccgaag accccgagca aagagaccga ttgcgccgca
3641761 agctgatcga ggatgaggca gtgcgcgtgt tggcgcgcaa ggaccgcacg ttgatcaccg
3641821 agaatcgact cgggctggtt caggcggccg ccggcgtgga cggatccaac gtcggccggt
3641881 ccgagttagc gctgctgccg gtcgatcctg acgccagtgc cgcaaccttg cgcgccgggc
3641941 tgcgcgagcg gctcggcgtc accgtcgccg tggtcatcac cgacaccatg ggacgcgcct
3642001 ggcgcaacgg ccagaccgat gccgcagtcg gcgctgccgg tctggcggtg ctgcgcaact
3642061 atgccggtgt ccgcgaccca tacggcaatg agttggtggt caccgaggtc gcagtcgccg
3642121 acgagatcgc cgcggccgcc gacttggtca aaggcaaact gaccgcgacg ccggtggcgg
3642181 tggtgcgtgg gttcggcgtg tccgacgacg gctcgacagc ccggcaactg ctgcggccgg
3642241 gcgccaacga cctgttctgg ctcgggaccg ccgaagcgct cgagctgggt cgccagcaag
3642301 cccaactgtt gcgcaggtcc gttcgccggt ttagcaccga tccggtgccg ggcgacctcg
3642361 tcgaggctgc ggtcgccgag gccctcaccg cgccagcccc acatcacacc cggccgaccc
3642421 gattcgtgtg gctgcagaca ccggccatcc gcgcgcggct gctagatcgg atgaaagaca
3642481 agtggcggtc tgatctcacc agtgacggct tgcccgccga cgcgatagaa cgccgggtgg
3642541 cacgcggcca gatcctctat gacgcacccg aagtcgtcat accgatgctg gtgcccgacg
3642601 gagcacacag ctaccccgat gccgcccgca ccgacgccga gcacaccatg ttcacggtcg
3642661 ccgtcggagc ggccgtacaa gccttgctgg tcgcgctggc cgtgcgcggg ctgggcagtt
3642721 gctggatcgg ctcgacgatc tttgccgctg acctggtccg cgacgagctg gacctgccag
3642781 tcgactggga gccgttgggc gccatcgcga tcggatatgc cgacgagccg tccgggttgc
3642841 gcgacccggt gcctgccgcc gatttgctga tcctgaagtg acattcgctc tagcgacgat
3642901 aggctaccca gacatggcgg tcctgcagcc gatgccaacc atcaacctcc cgacggatca
3642961 attcaccgcg ttcggtcaaa agtggctcct cggctcgaaa ttctccaaga aggacgacag
3643021 gacttaggcg ccgtgataga tgccgctgtg ggcggcgcac tgtcggtgat gctcggcaac
3643081 atcccattgg tggttccgaa cgccaaccag ctgtaacctt cccaagcgcc gacgtgtacc
3643141 gctgctatcc ggcccgattc cagggacagc caccccatgc aacctagtca tccgacgcgc
3643201 cctggtgcgg tcatcagata tgtcggtagc tcccttgata cttgtcccat gacgacgttc
3643261 gccggcaaaa cggctgcgtc cgctgacaag gtgcgcgggg gctactacac gccgccggcg
3643321 gtggcccgat tccttgccca ctgggttcac caggcggggc cgaagatcct cgaaccatcc
3643381 tgcggcgatg gccgaatcct gcgcgaactc tccgccatca cagaccacgc gcacggtgtg
3643441 gaactcgttg cgcgcgaggc gaaaaagtcg cgggacttcg cgtccgtcga cactgagaac
3643501 ctttttacct ggctgcacaa gacccaactc ggcagctggg atggcgttgc cggcaacccg
3643561 ccctacatcc gcttcggaaa ctgggcatcc gaacaacggg atccggcact cgaattgatg
3643621 cggcgtgtgg gcctacgacc gaccaaactg accaatgcct gggtcccgtt tgtcgtggcg
3643681 agcacgacgc tagcgcgtga cggcggccga gtgggcctgg tggtcccggc ggaattgctt
3643741 caagtcacct acgcggcgca gctacgcgaa ttcctgctga gccgctatcg ggagatcacc
3643801 ctggttacct tcgagcggct ggtgttcgac ggaatcctgc aggaagttgt gctgttctgc
3643861 ggcgtcgtcg gtcccggtcc tgcacacata cgcaccgtca ggctcggcga tgcgaacgat
3643921 ctgaacgcgc tgggggacaa ggacttcacc aatgagtcag cgccggcgct tctccacgaa
3643981 aaggagaagt ggaccaagta cttcctcgac cccgctcaaa tccggctact gcgaggactc
3644041 aaacagtccg ccactatgat caggctcggc gaactggccg acgtggatgt gggcatcgtg
3644101 accggccgca acagcttctt cacgttcacc gatgccaagg cacaagcgct gggattgcga
3644161 gcgcactgcg ttcccctggt ctctcgcagc gcccaactca gcgggctgat ctatgacgag
3644221 gattgccggg catgcgatgt cgccggcaac caccgaacgt ggctactcga cgccgcggac
3644281 tatccaaccg atccagctct cgtcgctcac atcaccgcgg gtgaagcggc cggcgtccac
3644341 ctcggctaca agtgctcgat ccgcaagcca tggtggagca caccatcgct gtggatgccc
3644401 gacctcttta tgctgcgcca gatccacttc gccccgcggc tgaccgtcaa cgctgccgcg
3644461 gcgaccagca ccgataccgt gcaccgggtc cggctcgacc cgaacgtcga tccggcaact
3644521 cttgccgcgg tgttccacaa cagcgcgaca ttcgcgttcg ccgagatcat gggccgcagt
3644581 tatgggggcg gcatcttgga gttggagcct agggaagccg agcaactacc tatgccaccg
3644641 ccggcgtacg ggagcgcaga acttgcccag gatgttgatc tcctgctgaa agcaaacgag
3644701 atcgacaagg cgctcgacgt cgtggaccgt cacgttctga tcgacgggct cggcttgtcg
3644761 ccgcgcctgg tcgcaggttg ccgagcggca tggctcacgc tccgcgaccg caggaccaag
3644821 cgcggatctc ggcgataacc gcggcgggtg agcgcctcgc gtgcccggcc aacgatgtcg
3644881 atctcggcgc aagaagctca aacgtcggac gagtaacgga tcccgccgtc gggaagaaag
3644941 acaccgggcc atacccgggc accacttaac aactcgcagc gcgcgccgat gtcggccccg
3645001 tcaccgatca caccgtcgcg gatcaacgcc cgcggtccga tgcgagcacc gaagccgatg
3645061 atcgaacgct cgatcacgca cccggcctcc acccggacac catcgaagat gaccgcgccg
3645121 tccaatctgg tgccggggcc gatttcggca ccacgcccca cgacggtgcc gccaatcagc
3645181 aacgcaccgg gagataccgc cgcaccgtcg tgcaccaact gctcaccgcg gtgaccacgc
3645241 aaggccggag acggggcgat gccgcgcacc agatccgccg atccgcgaac gaagtcttcc
3645301 ggtgtgccca tgtcccgcca atagctggca tcgacatagc cgtagatctt gcagtcgccg
3645361 tcggcgagca aggccgggaa cacctcgcgt tccaccgaaa cctcccggcc ctgcggaatc
3645421 cggtcgatga cgttgcgttc gaagacatag cagccggcat tgatctggtc ggtcggcgga
3645481 tcctccgtct tctccagaaa ggcgactacg cggtcctcct cgtcggtggg tacgcagccg
3645541 aatgcccgcg ggtcgcccac ccgcaccagt tgcagcgtga catcggctcg attgcttcgg
3645601 tggaagtcca gcagttgggc cagatccgcg cccgagagca catcgccgtt aaacaccatc
3645661 gcggtgtcgt tgcgcagctt gccggcaacg ttggcgatgc cgccgccagt ccccaaggga
3645721 tgctcctcgg tcacgtattc gatctgtagg cccagtgcgg acccgtcgcc gaactccgct
3645781 tcgaagactg cgggtttgta ggacgtaccc aggatcacgt gctcgatgcc cgctgcggcg
3645841 atccgcgaca gcagatgggt gaggaacggc agtccggcgg taggcagcat tggcttgggc
3645901 gccgacagcg tcaacggccg cagtcgggta cccttgccac cgaccaggac caccgcatcg
3645961 acttggtgag ttgccaactc agtgccgccc ttctaccagc ttcagtttcc gtctgcggga
3646021 cctgcgcagt gaactgcgca ccatgaggtg ggaacgcagc gccagtgatc cccgcagggt
3646081 ccagcgcagc ggagcccgcc accaaccaga atgtcggtcg gctaagaaga tataggtgct
3646141 tttgtgatgg gcggccagat ggcttgccgg gtcgcgaccc gtcgaatgcg ccttgtggtg
3646201 cagaacctcg gctgacggca catacaccga cagccaaccg gctttgccaa gccggtcgcc
3646261 aaggtcgacg tcctccatgt acatgaagta acgttcgtcg aatccgccga cctggccaaa
3646321 cgccgaccgg cgcaccagta ggcaagaccc cgacaaccaa cccaccggcc gttcactggg
3646381 ctccagccgc tcctgccggt aggccgtcgt ccacggattg cgcggccaga acggcccgag
3646441 cactgcgtgc atgccgccgc ggatcaggct gggcatctgc cgcgccgacg ggtacaccga
3646501 cccgtcgggg tcccgaatca gcgggcccag cgcgcccgcg cggggccagc gggaggcggc
3646561 gtccagtagt gcatcgatac tgcccgggcc ccattgcacg tccgggttgg ccacgatcac
3646621 ccagtcatcg acccagggtt cgccggcatc gcccgccatt tcaccgagct gggcgatcgt
3646681 ccgattcacc gcggttccgt acccgaggtt ggcccctgtg ggcagcagcc gcacgttggg
3646741 gtagcgctgc accgcggcct gcggggtgcc gtcggtggag ccgttgtctg ccaacagcac
3646801 gctgaccggc cgctcggtgg ccagcgacaa cgacgccagg aaccgctcta gatggggccc
3646861 cggcgagtag gtcaccgcta ccaccggcag gacgtcagtc acgcgttgag ggtaaccgtc
3646921 gatcgatcga agttgagttc gcaggtgctg ccagcgccgt ggccagtgcg ctgcgccagt
3646981 gccgtagcgg cgtcaagccc gccagcgccc actgcctgct cgacagcgcg gaatagctcg
3647041 aacgcggcgc gggccgcgga aactgcgcgc tgctgaccgg acgcacccgc tgtgggtcgg
3647101 caccgcattc ttcgaacacc gcgcgggctt gaccgaaccg ggagaccacg ccctcgttag
3647161 cggcgtgcaa cacgcgtccg cgcacgcccg cgtcggccaa cgccagcagc gcctcggcca
3647221 ggtcggcgac gtaggtcggc gacccggtct ggtcgtcgac cacatccacc cgaccgtgtc
3647281 cggcggccag ccggcgcatg acggcgacga aatccttgcc ggtcccgccg gtgtagaccc
3647341 aggcggtccg taccacggca gcctccggga acgctgccag cacagcctgc tcgccggcga
3647401 gtttgctgcg ggcatacacg ccctgcggcg cggtttcatc ggtgggctcg tagggccggg
3647461 gctcggcgcc gccgaagtcg ccatcgaata cgtagtcggt ggagacgtgg attaaccgag
3647521 cacccacacg agcgcacgca cgggcgaggt gttgcgggcc agtggcattg accgcatagg
3647581 cgactgcctc attgctctcg gcgccgtcga cgtcggtgta ggcggcgcaa ttgatcacca
3647641 cgtcaccgtg tcggatgatc cgctcggccg cagcggggtc ggtgatatcc cactgcgagg
3647701 aagtcagcgc cagcatatcg cggccttccc gggcggcctg tgccgtcaga tggctgccca
3647761 gctgcccgcc cgcaccggtg atgactagcc tttctgacct gcccgccatg tgtttgagtc
3647821 tggcacgcct cgggcacgcc ggggttggct acccgacagg gcgccgttac acaagtagtc
3647881 tagtgtgatg tctgcgcaac gtgtggttcg tacggttcgt accgctcggg ctatttccac
3647941 ggcactggcc gtcgcgatcg tccttggcac cggggtggcg tggagcagtg tccggtcgtt
3648001 cgaagacggc atcttccaca tgtcggcgcc ctcgctgggg cacggcggcg acgacggcgc
3648061 gatcgacatt ttgctggtcg gcctggacag ccgtaccgac gcgcacggca acccgttgag
3648121 cgccgaggaa ttggcgacat tgcacgccgg cgacgaggaa gccaccaaca ccgacaccat
3648181 catcctgatc cgggtaccca acaacggaaa gtcggcgacc gcaatctcta taccgcggga
3648241 ctcctacgtc gcggctcccg gtctgggtaa gaccaagatc aacggcgtct acgggcaaac
3648301 cagagagacc aagcgggccg gcctggtcca agccggtgcc tcgccgaccg aagcggccgc
3648361 cgccggcacc gaggccgggc gtgaggcgtt gatcaagacg gtcgccgatc tgaccggcgt
3648421 caccgtcgac cactacgccg agatcgggct gctcggtttc gcgttgatcg ccgacgcact
3648481 cggcggcgtc gacgtctgcc tcaaagagcc tgtatacgaa ccactttcgg gtgccgattt
3648541 tccagccggg cggcaaaagc tcaacggtcc gcaagcgctc agcttcgttc gccagcggca
3648601 tgatctgccc cgcggcgacc tggaccgggt ggtacgtcag caggcggtga tggcggcgtt
3648661 ggcccaccgg gtcatctccg gacagacgct atccagcccc gccacgctga agcggttgga
3648721 gcaggccgtg cagcgctcgg tggtgctgtc ctccgggtgg gacatcatgg atttcgtccg
3648781 ccaattgcag aagctggccg gcggtaacgt tgccttcgcc accatcccgg tgctcgacgg
3648841 cgccggctgg agcgacgacg gcatgcaaag cgtggtgcgg gtggatccgc gtcaggtgca
3648901 ggactgggtc gtcggcctgc tgcacgagca ggaccagggc aagaccgacg agctggccta
3648961 cacacccgcc aagaccacgg ccaacgtggt caacgacacc gatatcaacg ggcttgcggc
3649021 agcggtgtca aaggtgttga gctccaaggg gtttaccacc ggatccgtcg gcaacaacga
3649081 cggcgaccac gtgcctggca gccaggtgcg ggccgcaaag gccgacgacc tgggcgcaca
3649141 gcaggtcgcc aaggaactgg gcgggttgcc ggtggtcgcc gatgcgtcaa tcgcgcctgg
3649201 gtcggtgcgg gtggtgctgg ccaacgacta cagcggtccg ggctccgggc tggggggtag
3649261 tgatccgaac ggcgtcgtat cgccggcccg cgcgttcaac ctcgggtccg ccgacgacac
3649321 gactcccccg ccgtcgccaa tccttaccgc cggctccgac gcgccggagt gcatcaactg
3649381 accacaccga ccaccctgag cggggcgatc ctggatccga tgctgcgcgc cgacccggtc
3649441 ggcccgcgca tcacctacta tgacgatgcc accggtgagc gcatcgagct atccgcggtg
3649501 acactggcta actgggccgc caagaccggc aacctgttgc gcgacgagct ggcggccgga
3649561 cccgccagcc gagtcgcgat cctattaccg gcccattggc agaccgcggc ggtgttgttc
3649621 ggcgtgtggt ggatcggtgc gcaagcgata ctcgacgatt ctcccgccga tgtggcactg
3649681 tgcaccgccg accgtctggc cgaagccgac gccgtcgtca acagcgcggc ggtagccggc
3649741 gaggtagccg tgctgtcgct ggatccattc ggtcgaccgg caaccggcct gccggtcggc
3649801 gtcaccgact atgcgaccgc ggtgcgggta cacggcgacc agatagttcc cgaacacaac
3649861 cccggtccgg tgcttgccgg tagatccgtc gagcagatcc tgcgcgactg cgcggcgtcc
3649921 gcggccgcca ggggtttgac ggcggcggat cgggtgctgt ccaccgcttc ctgggccgga
3649981 cccgatgagt tggtggacgg cctgctggcg atcctggccg ccggtgcgtc gttggtgcag
3650041 gtggccaatc ccgatccggc gatgctgcag cgcaggattg cgaccgaaaa ggtcacccgc
3650101 gtcctgtgac gcaggccgcg tccagcaggc gaaggcatca gagcaataca tattgatatc
3650161 gcgatatata gatgttaatg tcactgcaac gagctgccgc tgcaattaca gacccggaag
3650221 aaaggtacag gcaatggcga tacaagtgtt cttggcgaag gcgacaacga cggtgatcac
3650281 cggcttggcc ggcgtgaccg cctacgagat cttaaaaaag gccgcggcca aagcgccgct
3650341 tcgtcagacc gcggtatcgg cagcagcgct gggtctgcgc ggaacccgca aggccgagga
3650401 agccgcggaa tcggcccgcc taaaggtggc cgacgtgatg gccgaggctc gtgagcgcat
3650461 cggcgaggaa tcgcccactc cagcgatcag cgacctgcac gaccacgacc actgagcgcc
3650521 tcgccatgac cctggaagtg gtatcggacg cggccggacg catgcgggtc aaagtcgact
3650581 gggtccgttg cgattcccgg cgcgcggtcg cggtcgaaga ggccgttgcc aagcagaacg
3650641 gtgtgcgcgt cgtgcacgcc tacccgcgca ccgggtccgt ggtcgtgtgg tattcaccca
3650701 gacgcgccga ccgcgcggcg gtgctggcgg cgatcaaggg cgccgcgcac gtcgccgccg
3650761 aactgatccc cgcgcgtgcg ccgcactcgg ccgagatccg caacaccgac gtgctccgga
3650821 tggtcatcgg cggggtggca ctggccttgc tcggggtgcg ccgctacgtg ttcgcgcggc
3650881 caccgctgct cggaaccacc gggcggacgg tggccaccgg tgtcaccatt ttcaccgggt
3650941 atccgttcct gcgtggcgcg ctgcgctcgc tgcgctccgg aaaggccggc accgatgccc
3651001 tggtctccgc ggcgacggtg gcaagcctca tcctgcgcga gaacgtggtc gcactcaccg
3651061 tcctgtggtt gctcaacatc ggtgagtacc tgcaggatct gacgctgcgg cggacccggc
3651121 gggccatctc ggagctgctg cgcggcaacc aggacacggc ctgggtgcgc ctcaccgatc
3651181 cttctgcagg ctccgacgcg gccaccgaaa tccaggtccc gatcgacacc gtgcagatcg
3651241 gtgacgaggt ggtggtccac gagcacgtcg cgataccggt cgacggtgag gtggtcgacg
3651301 gcgaagcgat cgtcaatcag tccgcgatca ccggggaaaa cctgccggtc agcgtcgtgg
3651361 tcggaacgcg cgtgcacgcc ggttcggtcg tggtgcgcgg acgcgtggtg gtgcgcgccc
3651421 acgcggtagg caaccaaacc accatcggtc gcatcattag cagggtcgaa gaggctcagc
3651481 tcgaccgggc acccatccag acggtgggcg agaacttctc ccgccgcttc gttcccacct
3651541 cgttcatcgt ctcggccatc gcgttgctga tcaccggcga cgtgcggcgc gcgatgacca
3651601 tgttgttgat cgcatgcccg tgcgcggtgg gactgtccac cccgaccgcg atcagcgcag
3651661 cgatcggcaa cggcgcgcgc cgtggcatcc tgatcaaggg cggatcccac ctcgagcagg
3651721 cgggccgcgt cgacgccatc gtgttcgaca agaccgggac gttgaccgtg ggccgccccg
3651781 tggtcaccaa tatcgttgcc atgcataaag attgggagcc cgagcaagtg ctggcctatg
3651841 ccgccagctc ggagatccac tcacgtcatc cgctggccga ggcggtgatc cgctcgacgg
3651901 aggaacgccg catcagcatc ccaccacacg aggagtgcga ggtgctggtc ggcctgggca
3651961 tgcggacctg ggccgacggt cggaccctgc tgctgggcag tccgtcgttg ctgcgcgccg
3652021 aaaaagttcg ggtgtccaag aaggcgtcgg agtgggtcga caagctgcgc cgccaggcgg
3652081 agaccccgct gctgctcgcg gtggacggca cgctggtcgg cctgatcagc ctgcgcgacg
3652141 aggtgcgtcc ggaggcggcc caggtgctga cgaagctgcg ggccaatggg attcgccgga
3652201 tcgtcatgct caccggcgac cacccggaga tcgcccaggt tgtcgccgac gaactgggga
3652261 ttgatgagtg gcgcgccgag gtcatgccgg aggacaagct cgcggcggtg cgcgagctgc
3652321 aggacgacgg ctacgtcgtc gggatggtcg gcgacggcat caacgacgcc ccggcgctgg
3652381 ccgccgccga tatcgggatc gccatgggcc ttgccggaac cgacgtcgcc gtcgagaccg
3652441 ccgatgtcgc gctggccaac gacgacctgc accgcctgct cgacgttggg gacctgggcg
3652501 agcgggcagt ggatgtaatc cggcagaact acggcatgtc catcgccgtc aacgcggccg
3652561 ggctgctgat cggcgcgggc ggtgcgctct cgccggtgct ggcggcgatc ctgcacaacg
3652621 cgtcgtcggt ggcggtggtg gccaacagtt cccggttgat ccgctaccgc ctggaccgct
3652681 agcagccgca gccgtgacca cgccaggtgc ggatgccctg ccagaccgcg ataccggcga
3652741 tggccagccc gatcgcgggg tcaatccacc agccgttcga ccacacggca gtgatcgcca
3652801 gcccaagcag aaccgcggcg gcctgagcag cacacaggta gttctgggtg ccctcgcccg
3652861 cggtggcccc cgatcccagc cgctcaccca ctcggtggtt ggcccagccc aggaccggca
3652921 tcagcagcag ggcgatggcc gtcagtccga tgccgatcac cgaggtctcg gcacgatgct
3652981 cgccggctag gtggcggatg gattcggcaa cgaggtaggg ggccgtcagc caaaaagaca
3653041 ccgcaactcc acgctgtgcg cggtgctccg cggtcgcgga ccaagtgcgg tcgccggtga
3653101 accgccagag caccatcgcg ctggccaggc cctcggatcc gccacccagc gcccacccgg
3653161 tcaacgcgac ggatccgacc gcaataccct gccacagccc cacggcacct tcggtgagca
3653221 ataccgccag gctgacccac gccagccagc gggcccaccg aacgttccgc tgccattcgg
3653281 cctctcgcgc caccgacacg ggcgaatcca gcgtggattc atcgcggtgt tccgtcgtcg
3653341 tctccatccc gacgatggta gaggcaagac atgccgggcg gtcgccgcgg cgtcgcgaac
3653401 ccgtatggtt cagggaggat gccgcacgcc agggaaggtc accaccgatg ccgaccagca
3653461 accccgccaa accacttgac gggtttcggg tattggattt cacccagaac gtggccgggc
3653521 cgctggccgg gcaggtgctg gtcgacctgg gggctgaagt catcaaggtg gaggcgcccg
3653581 gcggtgaagc ggcccgtcag atcacctcgg tgttacccgg acgcccgccc ctggccacct
3653641 actttctgcc caacaatcgt ggcaagaagt cggtgacggt ggacctaacc accgagcagg
3653701 ccaagcagca gatgctgcgg ctcgcggaca ccgccgacgt tgtcttggag gcgtttcggc
3653761 ccggcaccat ggaaaagctg ggcctaggcc ctgatgactt gcgctctcgt aaccccaacc
3653821 tgatctacgc gcgcctaacc gcttacggcg gcaacggccc gcacggcagc cggccgggaa
3653881 tcgacctggt ggtggccgcc gaggccggca tgaccaccgg aatgcccacg cctgagggca
3653941 agccacagat catcccattt cagctcgtcg acaacgccag cggtcacgtg ctggcccagg
3654001 ccgtgctggc cgcgctgctg caccgcgagc ggaacggggt ggccgacgtc gtccaggtcg
3654061 cgatgtacga cgtcgcggtg ggactacaag ccaaccagct gatgatgcat ctcaatcggg
3654121 ccgctagcga ccagccgaag cctgaaccgg caccgaaggc caagcggcgc aagggagtcg
3654181 gcttcgctac ccagccatcg gacgcgtttc gcaccgccga tgggtacatc gtcatcagcg
3654241 catatgtgcc caaacactgg cagaagctgt gctacctcat cggccggcct gacctcgttg
3654301 aagatcaacg atttgccgaa caacgctccc ggtcgatcaa ctacgccgag ttgaccgccg
3654361 agttggaatt ggcactggcc agcaagaccg ccaccgaatg ggtccagttg ctgcaggcaa
3654421 acggcctcat ggcctgcctc gcccatacct ggaaacaggt cgtcgacacc ccccttttcg
3654481 ccgagaacga cctcaccctg gaagtcggtc gcggggcgga caccatcacg gtgatccgca
3654541 caccggcgcg ctacgccagc ttccgcgcgg tcgtcaccga tcccccgccc accgccggcg
3654601 aacacaatgc cgtgtttctg gcccggccct gacgctgtga ccattccgag gagtcaacac
3654661 atgagcaccg cagtcaacag ctgcaccgag gcgcccgcat cgcgatcaca gtggatgctg
3654721 gctaatctgc ggcacgatgt tcccgcatca cttgtcgtct tccttgttgc gttgccactt
3654781 tcgctgggga tcgcgatcgc ctccggggcc ccgataatcg ccggtgtgat cgccgccgtc
3654841 gtaggcggca ttgtcgccgg ggcggtcggt gggtcgccgg ttcaggtcag cggcccggcc
3654901 gcgggtctga ccgtggtggt cgccgagctg atcgatgagc tcggttggcc gatgctgtgt
3654961 ctgatgacga tcgccgcggg tgcactgcag atcgtgttcg gcctaagtcg gatggcgcgc
3655021 gccgcgctgg ccatcgcccc ggtcgtggtg cacgccatgc tggccggcat cggtatcacc
3655081 atcgcgctgc agcaaattca tgttctgctc ggtggtacgt cgcacagctc ggcgtggcgg
3655141 aacatcgtag cgttgccgga cggcatcctc catcacgaac tgcacgaagt gatcgtcggc
3655201 gggacggtta tcgcgatcct gttgatgtgg tcaaagctgc ccgccaaggt gcgtatcatt
3655261 cccggcccac tggtagccat cgcgggcgcg accgtgcttg cgttgctacc cgtgctacaa
3655321 accgaacgaa tcgacctgca gggcaacttc ttcgacgcga ttggcttgcc caaacttgcc
3655381 gaaatgtccc cgggaggaca gccgtggtct catgagatca gcgccatcgc gctcggtgtc
3655441 ctcaccattg cgctgatcgc aagcgtcgaa tcgctgctgt cggcggtcgg tgtcgacaag
3655501 ctgcatcacg gcccgcgcac cgacttcaac cgggagatgg tcgggcaggg cagcgcgaac
3655561 gtggtgtccg gattgctcgg cgggctgccc atcaccggtg tcatcgtgcg cagctcggcc
3655621 aacgtggccg ccggcgcccg aacccggatg tcgacgatcc tgcacggagt gtggatcctg
3655681 ctgtttgcgt cactgttcac caacctggtg gaactgattc ccaaggcggc gctggccggc
3655741 ctgctcatcg tgatcggtgc ccagctggtc aagctggcgc acatcaaact agcttggcgc
3655801 acaggaaatt tcgtaatcta cgccatcacc atcgtgtgtg tggtgttcct caatctgctg
3655861 gaaggcgtgg ccatcgggct ggtcgtggcg atcgtattcc tgttggtgcg ggtggtacgc
3655921 gcgcccgtcg aggtcaagcc ggtcggcggc gagcagtcca agcgatggcg ggtcgatatc
3655981 gacggcacgt tgagcttcct gctgctgccc cgcctgacca cggtgctctc gaagctgccg
3656041 gaagggtcgg aggtgacgtt aaacctgaac gcagactaca tcgacgactc cgtttccgag
3656101 gccatctccg attggcggcg cgcccacgag acgaggggcg gagtggtagc gatcgtggaa
3656161 acgtcgccgg ccaaactgca ccacgcacac gcccgaccac cgaagcgcca cttcgcgtct
3656221 gatccgattg gactggttcc gtggcgatca gcgcgcggca aagaccgcgg cagcgcttcg
3656281 gttctcgacc gcatcgacga gtatcaccgc aatggcgcgg ccgtgctgca cccgcatatc
3656341 gccgggctga ccgattcaca ggacccgtat gagctgttcc tcacctgtgc cgactcgcgg
3656401 attctgccga acgtcatcac cgccagcggc cccggcgacc tgtacaccgt ccgcaacctc
3656461 ggcaacctgg tgccgaccga tccggacgac cgatcggttg acgcggcact cgacttcgcc
3656521 gtcaaccagc tcggcgtcag ctcggttgtc gtctgcggac attcgtcgtg tgctgcgatg
3656581 acggcgctcc tggaagacga cccggccaac acgacgactc ccatgatgcg ttggctcgag
3656641 aatgcccacg acagcctggt ggtgttccgc aatcaccacc cggcacgccg cagcgccgaa
3656701 tccgccggtt accccgaagc cgaccagctg agcatcgtaa acgttgccgt tcaggtggaa
3656761 aggctgaccc gccacccgat cttggcgacc gcggtcgccg ctgctgatct acaggtcatc
3656821 ggcatattct tcgacatctc gaccgcccgg gtatacgagg tgggtccgaa cggcatcatc
3656881 tgcccggacg agccggccga ccgccccgtc gaccacgaat cagcgcagta gcgcccgcga
3656941 catcactacc cgctgaatct gattggtgcc ctcatagatc tgggtgatct tggcgtcgcg
3657001 cataaaccgc tcgaccggga agtcggtggt gtagccggcg ccgccgaaca gttgtacggc
3657061 atcggtggtg acctccatcg cgacgtcgga ggcgaagcac ttcgaggccg ccgaaatgaa
3657121 gcccagatcc ggctcaccgc gttcggcgcg ggcggcggcg gagtaaacca tcagccgagc
3657181 cgcctccacc ttcatcgcca tgtcggccag catgaactgc acggcctgaa acgtactgat
3657241 cgactcaccg aactgcttgc ggtccttggt gtaggcgatg gcagcatcca gcgcgccctg
3657301 ggcgataccc acggcctgcg cgccaatcgt gggacgggtg tggtccaacg tggccagcgc
3657361 ggtcttgaaa ccggtaccgg gctcaccgat gatgcgatcg ccggggatgc ggcagttctc
3657421 gaagtacagc tcggtggtcg gtgacccctt gatcccgagc ttgcgttctt tcggaccgac
3657481 ggtgaacccc tcgtcgtcct tgtgcaccat gaacgccgag atgccgttgg cgccccggtc
3657541 gggatcggtc accgccatca ccgtgtacca ggtcgacttg ccgccgttgg tgatccagca
3657601 cttggcgccg ttgagaatcc agtgatcccc atcggccttg gcccgcgtcc gcatggacgc
3657661 cgcgtcactg ccggcctcgc gttcactcaa tgcataggaa gccatcgccc cttcggcggc
3657721 caacgccggc agcacctgct tcttcagctc ctcggagccc cgcaggatca ggcccatggt
3657781 gcccagcttg ttgaccgcgg ggatcaacga cgcggacgcg tcgacgcggg ccacctcttc
3657841 gatcacgatg caggtagcta ccgagtcggc accctgaccg ccgtactcct ccggaatgtg
3657901 gacggcgttg aaaccggagg aattgagcgc cactagcgct tcttcgggga accgcgcctt
3657961 ctcgtccacc tcggcggcat gcggagcgat ctccttttcc gccaaagccc gtatcgccga
3658021 tcgcatttcg tcgtgttcct cgggcagctt gaacagatcg aacgacgggt ttccggccca
3658081 tccaaccatc ttggagccct cctaatctcc gtgctagtcg cgggttaact tacccgcaag
3658141 ccgctgcagt tccgcatcct tggccgccac gacgtcggcc agccggtcct ggaatgcgac
3658201 gatccgggcc ctcagctggg ggttggcggc tcccagcatc cgcaccgcca gcagtccggc
3658261 attaccggcg cccccgatgg acaccgtggc caccggaacc ccggccggca tttgcacgat
3658321 cgacagcagg gagtcaaggc cgtccagcct gcccagcggt accggcaccc cgatcaccgg
3658381 cagcggcgtc gcggcggcga ccataccggg caagtgcgcg gccccgcccg ctccggcgat
3658441 gatcacctcg agaccgcgct cggccgcgcc gcgcgcataa ctgaacatcg cctcaggggt
3658501 gcgatgggcc gaaacaaccc gaacctcggc cggaatgtcg aactcggcca gcgccgccgc
3658561 agcgtcggcc atcaccggcc agtcgctgtc gctgcccatg atcaccccga cccggggccg
3658621 ctcgccggca ggagtcatag gcgccgctcc tcctcatcgc ttcgtccccc gcacgcgggt
3658681 ggtaccccca ctgcatcgtc gctggcgcgg tgtgggtccc atccgtcagt ccaccgccca
3658741 tgggacaacc agtgtgccgc cagctcagcg cgttcacaca actgggcgac atcggagcca
3658801 aggaagttga tatgccccac cttgcgaccg ggtcgctcgg ccttgccgta gaggtgaacc
3658861 cgggcgtcgg gcattcgcgc aaacagatgg tgcagccgct cgtcgacgct catggccggc
3658921 ggctgcgcgg cgccgagcac attggccatc accgtcacgg gcaccacggc gtcgctgtcg
3658981 ccgagcgggt agtccaagac cgcgcgcaga tgctgctcga actggctggt gcgcgccccg
3659041 tcgatggtcc agtgcccgga attatgtggc cgcatcgcga gctcgttgac cagcaacgcc
3659101 ccgtcggtcg tctcgaacag ctcgacggcg agcacgccga ccacaccgag ttcgtcggcc
3659161 agctgcaacg ccaaccgttg cgccgcggtg gccaggtcgt cgggcagcgc cggcgccggc
3659221 gcgatcacca gcacacacgt gccgtcacgt tgcaccgtct ggaccaccgg ccacgccgca
3659281 ccctggccga acggcgaacg cgccaccagt gccgacagct cgcggcgcag gtccacccgt
3659341 tcctcgacca gcaccgccac gccgtcagcc aggcattcgc gagcgaaatc acgggcatcc
3659401 gccacatcac gtgccatccg aacgccccgg ccgtcgtaac ccccgcgcac tgccttgacc
3659461 acgatcgggg cgtcgacacg tgcggcgaag acgtcgattt cgtcggggtc tttgatgccc
3659521 gcgtagcggg gcacggcgac gcctgctgca gccagacgct gccgcatgac gagtttgtcc
3659581 tgggcgtgca ccagcgcctg cggcgacggt gcgacattga cgccatcggc gactagcttc
3659641 tccaacagct cgttcgggac gtgctcgtgg tcaaaggtca gcacgtcggc gccggccgca
3659701 acgcggcgca aggcggcaag atcggtgtgc gagccgatca ccacgttggg ggtgacctgc
3659761 gcggcagggt catctgccga ggtgaccaat acacggaggt tctgccccag cgcgatggca
3659821 gcctgatggg tcatccgggc cagctgaccg ccaccgacca tcgcaacgag gggggcaatg
3659881 aacgaggtga ccgccggggt gcgtgagctc gccacggcca tcatggtgtc acggcatctg
3659941 accggcgtac ttgccggcca cggcagccaa accgttacgt atcattttgc gtcgattttg
3660001 tgttcgtccg tacactcact tgttgtgtcc tttgccgatg ccaccatcgc gcgccttccc
3660061 ggggtggtcc agccctatgc gcagcgccac catgagctga tcaaatttgc catcgtcggc
3660121 ggcaccacat tcatcatcga cacagcaatt ttctacaccc tcaagctgac ggttctcgaa
3660181 cccaagccgg tgaccgcgaa ggtgatcgcc ggcatcgtcg ccgtcatcgc gtcctacgtg
3660241 ttgaacaggg agtggagctt ccgcgaccgc ggcggtcgcg agcgccacca tgaggcgctg
3660301 ctgttctttg cgttcagcgg cgtgggagtg ctgctgagca tggcgccgtt gtggttttcc
3660361 agctacatcc tgcagctacg ggtgccaacg gtgtcactga ccatggaaaa catcgccgac
3660421 ttcatctcgg cctacattat tggcaacttg ctgcaaatgg cgttccgctt ctgggcgttt
3660481 cggcgctggg tgttccccga cgagttcgcc cgcaaccccg acaaggccct ggaatccgcc
3660541 cttaccgcgg gcggcatcgc cgaagtcttc gaggacgtct tggagggcgg cttcgaggac
3660601 ggcaacgtca ccctgctgcg ggcctggcgt aaccgggcca accggttcgc tcagctgggc
3660661 gactcgtcgg agcccagggt gtcgaaaacc tcgtgataca gcaacgcatg cacctcccgc
3660721 aggcgcggaa tgttgtagaa ctcgagcgga tcttgtgacg cggactcgat aatcaacgtc
3660781 ccggtgcgaa aaatccgctc gaagatccgg tcccggaact ccacgctgtt gatccgtgct
3660841 agcggtatgt cgatcccgct gcgggtcagc acaccatgcc ggaacatcac ccgccggttg
3660901 gtcaccacga aatgtgtggt cagccagctc aggaatggcc acagcgtgag ccagccgacg
3660961 atcaccaacc agatccccca gatgaccgcg tgaatcacgt tcttagcgat ctgctgccaa
3661021 ggtgtcgagt tgacgaatcc ggacccgaac gccgccaacc cggtcagcaa gaccagcacc
3661081 acgacgggcc agattaagcg attccagtgc ggatggcggt gcagaacgac ctgctcgcca
3661141 gcggccagga cattctccgg atagctcatg cccgcgacct taatcttttg gggacgccag
3661201 ctccgcgcga gttaacgcaa atgcaccacg tcgcccgctg aaacaactac cgttcgaccg
3661261 ccgacgtcca gacacagccg accctggtca tcgatgtcac gcgcgatccc gacgacgtcc
3661321 tggccaccgg ggagctcgac gcgcacgcgc gacccaatgg tcaggctgcg agcacggtag
3661381 tcggccgcca gttgtgggtt ggcgttgcgc cactggatga tccgagcttc gagctcgcgc
3661441 aacagcctgc tggctatgcg gttgcggtcc ggtgccgcca ctccgaggtc cagcaatgag
3661501 gtcgcgtcgg gatcaacctc ttcgggggcc tgggtgacgt tgagtcccac accgagtacc
3661561 acaaacggct gcgcgacctc ggccaggatg ccggctaact tgccaccccg ggccagcacg
3661621 tcattgggcc acttgaggcc cgtttcggcc ggcgggactg caatcagggg ggccaccgaa
3661681 tcgagcaccg ccagacccgc ggccagtgac agccagcccc acgcttgcac cgggacgtcg
3661741 accacacgca caccgaccga caggatgatc tgcgctcggg cagtggccgc ccagccgcgg
3661801 ccatgacgcc cccgcccagc ggtctgatgc tcggcgatca acaccacccc gtcgatatcg
3661861 gccccggatg ccgcccgggc cagcaagtcg gcgttggtgg aaccggtttg ggccacgacg
3661921 tcaagttggc gccacccgga tccagcaccg atcagctggt cgcgcagtga gcgttcgtcc
3661981 aaaggcggcc tgagccgatc gcggtcggtc accgccccag cctaaggaag tagtgtgcgg
3662041 cagccgataa catcgactcc catgacaagc gttaccgacc gctcggctca ttccgcagag
3662101 cggtccaccg agcacaccat cgacatccac accaccgcgg gcaagctggc ggagctgcac
3662161 aaacgcaggg aagagtcgct gcaccccgtc ggtgaggatg ccgtcgaaaa agtacacgcc
3662221 aagggcaagc tgacggctcg cgagcgtatc tacgcgttgc tggatgagga ttcgttcgtc
3662281 gagctggacg cgctggccaa acaccgcagc accaacttca atctcggtga aaaacgcccg
3662341 ctcggcgacg gcgtggtcac cggctacggc accatcgacg ggcgcgacgt gtgcatcttc
3662401 agccaggacg ccacggtgtt tggcggcagc cttggcgagg tgtacggcga gaaaatcgtc
3662461 aaggtccagg aactggcgat caagaccggc cgtccgctca tcggcatcaa cgacggtgct
3662521 ggcgcgcgca tccaggaagg tgtcgtctcg ctgggcctgt acagccgtat ctttcgcaac
3662581 aacatcctgg cctccggcgt catcccgcaa atctcgttga tcatgggagc cgccgccggt
3662641 gggcacgtct actcccccgc cctgaccgac ttcgtgatca tggtcgatca gaccagccag
3662701 atgttcatca ccgggcccga cgtcatcaag accgtcaccg gcgaggaagt caccatggaa
3662761 gaactcggcg gcgcccacac ccacatggcc aagtcgggta cggcacacta cgccgcatcg
3662821 ggcgaacagg acgccttcga ctacgttcgc gagctgctga gctacctgcc gcccaacaac
3662881 tccaccgacg cgccccgata ccaagccgca gccccgacag ggcccatcga ggagaacctc
3662941 accgacgagg acctcgaatt ggatacgctg atcccggact cgcccaacca gccctatgac
3663001 atgcacgagg tgatcacccg gctcctcgac gacgaattcc tggagataca ggccggttac
3663061 gcccaaaaca tcgtggtggg gttcgggcgc atcgacggcc ggccagtcgg cattgtcgcc
3663121 aaccagccga cacacttcgc cggctgcctg gatatcaacg cctcggagaa agcggcccgg
3663181 tttgtgcgga cctgcgactg cttcaatatc cccatcgtca tgctggtgga cgtcccgggc
3663241 ttcctgccgg gcaccgacca ggaatacaac ggcatcatcc ggcgcggcgc caagctgctc
3663301 tacgcctacg gcgaggccac cgtgccaaag atcacggtca tcacccgcaa ggcctacggc
3663361 ggtgcgtact gcgttatggg ctccaaagac atgggctgcg acgtcaacct ggcgtggccg
3663421 accgcgcaga tcgcggtgat gggcgcctcc ggcgcagtgg gcttcgtgta ccgccagcag
3663481 ctggccgagg ccgccgccaa cggcgaggac atcgacaagc tgcggctgcg gctccagcag
3663541 gagtacgagg acacactggt caacccgtac gtggccgccg aacgcggata cgtcgacgcg
3663601 gtgatcccgc cgtcgcatac tcgcggctac atcgggaccg cgctgcggct gctggaacgc
3663661 aagatcgcgc agctgccgcc caaaaagcat gggaacgtgc ccctgtgagt cgagtgagcg
3663721 gaacgaacct gtgagtcgag tgagcggaac gaacgaagtg agtgacggga acgagacgaa
3663781 caatccggca gaagtgagtg acgggaacga gacgaacaat ccggcagaag tgagtgacgg
3663841 gaacgagacg aacaatccgg cccctgtgag tcgagtgagc ggaacgaacg aagtgagtga
3663901 cgggaacgag acgaacaatc cggcccctgt gagtcgagtg agcggaacga acgaagtgag
3663961 tgacgggaac gagacgaaca atccggcccc tgtgaccgag aagccgctgc atccgcacga
3664021 gccccacatc gagatactgc ggggacaacc caccgatcag gagctggccg cgttgatcgc
3664081 ggtgctgggc agtatcagcg gttcaacccc gcccgcgcaa cccgagccca cccggtgggg
3664141 gctgccggtc gaccagttgc ggtaccccgt cttcagttgg cagcgcatca cactgcaaga
3664201 aatgacgcac atgcgccgat gacccggctg gtgctcgggt ccgcctcccc tggccggctc
3664261 aaagtccttc gtgatgccgg cattgagccg ctggtcatcg cctcgcacgt cgacgaggat
3664321 gtcgtcatcg cggcgctggg gccggacgcg gtcccgagcg atgtggtgtg cgtactggcc
3664381 gcggcaaagg ccgcgcaggt cgcgaccacg ctgaccggaa cgcaacgcat tgtggccgcg
3664441 gattgcgttg tcgttgcctg tgattcgatg ctctacatcg aaggcaggct actcggcaag
3664501 ccagcgtcaa tcgacgaggc gcgcgagcag tggcggtcga tggcgggccg ggccggccaa
3664561 ctctatacgg gccacggtgt tatccggttg caggacaaca aaaccgtgta ccgtgctgct
3664621 gaaacagcaa taaccacagt atatttcgga acaccttcgg cctccgatct ggaggcttac
3664681 ctggccagtg gggagtcgct gcgggtcgcg ggtggattca ccctggacgg tctgggcggc
3664741 tggttcatcg acggcgtgca gggcaatccg tcgaatgtga tcggcttgag cctgccgttg
3664801 ctgcggtcgc tcgtgcagcg atgcgggctg tccgtcgccg cactgtgggc aggaaatgcg
3664861 ggcggcccag cgcacaagca gcagtagctt cggactgggc caggtcgcca gcggtaggct
3664921 cgatgatgtg ccgcttcccg cagaccctag ccccaccttg tcggcctacg cccatcccga
3664981 acggctcgtg accgccgact ggttgtcggc acacatgggc gcgccgggcc tggcgatcgt
3665041 cgaatccgac gaggacgtct tgctctacga cgtcggccat attcccggcg ccgtcaagat
3665101 cgactggcac accgacctca acgacccacg ggtgcgcgac tacatcaacg gcgagcagtt
3665161 cgccgaattg atggaccgca agggcatcgc ccgcgatgac accgtggtga tctatggcga
3665221 caagagcaat tggtgggccg cctatgcgtt gtgggtgttc acgctgttcg gtcacgccga
3665281 cgtgcgactc ctcaacggcg gccgtgacct ctggctcgcc gagcgccggg aaaccacctt
3665341 ggacgtcccg accaagacct gcaccggtta tcccgtcgtg cagcgcaacg atgcacccat
3665401 ccgcgcattc agagacgacg tgctggccat cctgggcgct cagccgctga tcgacgtacg
3665461 ctctcccgag gagtacaccg gcaagcgcac ccatatgccc gattaccccg aggaaggggc
3665521 gctgcgggcc ggtcacatcc ccacggcggt gcacattccg tgggggaagg ccgccgacga
3665581 aagtggacgg tttcgcagcc gcgaggaatt ggaacggctc tatgacttca taaacccgga
3665641 cgaccaaacc gtcgtctatt gccgcatcgg tgaacgctcc agccatacct ggttcgtgct
3665701 cacacacctg ctgggcaagg cagatgtacg gaactacgac ggctcgtgga ccgagtgggg
3665761 caacgccgtg cgagtgccga tcgtcgcggg cgaagaacca ggagtggtac ccgtcgtatg
3665821 accgcgcccg cgagcctgcc cgcgccgcta gcagaggtgg tatccgactt cgccgaagtc
3665881 cagggtcaag acaagctgag gctgttgctg gaattcgcca acgagctgcc ggcgcttccg
3665941 tcgcacctgg ccgagtccgc tatggagccg gtccccgagt gccagtctcc gctgtttttg
3666001 cacgtcgacg cgagtgaccc caaccgggtg cgcctgcatt tcagcgcgcc ggccgaagcg
3666061 ccaaccacgc gcgggttcgc ctcgatcctg gccgccggcc tagacgagca accggccgcc
3666121 gacatcttgg cggtgcccga ggatttctac accgagctgg gtctggctgc cttgatcagc
3666181 ccactgcggt tgcggggaat gtcggcgatg ctggcccgga tcaagcgccg gctgcgcgaa
3666241 gcggactgaa tcgaggaacc gcgtgagcgg gtcagcggcg cgacgcttaa acttcccccg
3666301 acaagacttg taagaaaatc tcttagagac gaagaatcag cccgacagga ggcgcagtgg
3666361 ctagtcacgc cggctcgagg atcgctcgga tctctaaggt tctcgtcgcc aatcgcggcg
3666421 agatcgcagt gcgggtgatc cgggcggccc gcgacgccgg cctgcccagc gtggcggtgt
3666481 acgccgaacc cgacgccgag tccccgcatg ttcggctggc cgacgaggcg ttcgcgctgg
3666541 gcggccagac ctcggcggag tcctatctgg acttcgccaa gatcctcgac gcggcagcca
3666601 agtccggggc caacgccatc caccccggct acggcttcct agcggaaaat gccgacttcg
3666661 cccaggcggt gatcgacgcc ggcctgatct ggatcggccc cagcccgcag tcgatccgcg
3666721 acctgggcga caaggtcacg gcccgtcaca tcgcggcccg cgctcaggcg cccctggtgc
3666781 cgggtacccc cgatccggtc aaaggcgccg acgaggtggt ggcattcgcc gaggagtacg
3666841 gcctgccgat cgcgatcaag gccgcccacg gcggcggcgg caagggcatg aaggtggccc
3666901 gcaccatcga cgagattccg gagctgtacg agtcggcggt gcgcgaggcc acggccgcgt
3666961 tcggccgcgg tgagtgctac gtggagcgct atctcgacaa gccgcgccac gtcgaagcac
3667021 aggtgatcgc cgaccagcac ggcaacgtcg tcgtcgccgg cacccgggac tgctcgctgc
3667081 agcgccgcta ccagaagctg gtcgaggagg cgcccgcacc gttcctgacc gactttcaac
3667141 gcaaagagat ccacgactcg gccaaacgga tttgcaaaga ggcccattac cacggcgccg
3667201 gcaccgtcga atacctggtc ggtcaggacg gcttgatctc gttcttggag gtcaacacgc
3667261 gccttcaggt agaacacccg gtcaccgagg aaaccgcggg catcgacttg gtgctgcagc
3667321 aattccggat cgccaacggc gaaaagctgg acatcaccga ggatcccacc ccgcgcgggc
3667381 acgccatcga attccggatc aacggcgagg acgcggggcg taacttccta ccggcgcccg
3667441 ggccggtgac aaagttccac ccgccgtccg gccccggtgt gcgggtggac tccggtgtcg
3667501 agaccggctc ggtgatcggc ggccagttcg actcgatgct ggccaagctg atcgtgcacg
3667561 gtgccgaccg cgccgaggcg ctggcgcggg cccggcgcgc gctgaacgag ttcggtgtcg
3667621 aaggcctggc gacggtcatc ccgtttcacc gcgccgtggt gtccgacccg gcattcatcg
3667681 gcgacgcgaa cggcttttcg gtacataccc gctggatcga gaccgagtgg aataacacca
3667741 tcgagccctt taccgacggc gaacctctcg acgaggacgc ccggccgcgt cagaaggtgg
3667801 tcgtcgaaat cgacggtcgc cgcgtcgaag tctcgctgcc ggctgatctc gcgctgtcca
3667861 atggcggcgg ttgcgacccg gtcggtgtca tccggcgcaa gcccaagccg cgcaagcggg
3667921 gtgcgcacac cggcgcggcg gcctccggtg acgcggtgac cgcgcctatg cagggcaccg
3667981 tagttaagtt cgcggtcgaa gaagggcaag aggtcgtggc cggcgaccta gtggtggtcc
3668041 tcgaggcgat gaagatggaa aacccggtca ccgcgcataa ggatggcacc atcaccgggc
3668101 tggcggtcga ggcgggcgcg gccatcaccc agggcacggt gctcgccgag atcaagtaag
3668161 cccggcggct actccaactg atcccgtagc cgtgccaatg acttggccag cagccgcgac
3668221 acgtgcatct gtgagatacc gacgcgctcg gcgatctgcg tttgggtcat cgagtcgaag
3668281 aacctgagca ccaagaccgt tcgttcccgc tcgggcaacg cctcgagcaa cggacgaagc
3668341 acctcccgat tctcgatctg gtcaagaccc gcatccacgt cgcccagggt gtctgtgatt
3668401 gcgcgggcat cgtcgtcgct gccgccaccg ctgtcgatgg acaaggtgtg gtaggaacta
3668461 cccgccagca aaccttcgat aacctcagcg cggtccatcc cgagctccgc ggcgagctcc
3668521 gatgccgacg gcgcccgccc gagccgctgc gacaaatcgg cggtggcggt acctagccgc
3668581 agatgcagtt ccttgagacg ccggggaacc ttgaccgacc agctgttgtc gcggaagtgt
3668641 cgtcggacct cgcccatgat ggtaggaacc gcgaaggaga cgaagtccga cccggtcttc
3668701 acgtcgaagc gaaccgcggc gttgaccagc ccgacccgcg cgacctgaat aaggtcgtca
3668761 cgcggttcgc cgcgaccctc gaaccgccgc gcgatgtgat cggccagcgg caagcaccgc
3668821 tgaacgatct tgtcccggtg ccgctggaat tccggtgagc cggcaggcaa accaaccagc
3668881 tcgcgaaaca tctccggaac gtcggcgtat tcgttagctc gcgatgcaga accgccggca
3668941 gcgcgcgccg tcacctgctg gatgccgccc gtcgggcggt caacgtgatg ccgaagacac
3669001 tgccggctac atcgggctgg cgaccgtcgt ggaaggtctg gacgtcgtcg gccagcgcgg
3669061 tcaggacatg ccagctaaag ctgcccggtg ccaccacgtc gtgggtgtcg caggcagcag
3669121 aagcctccac cacaacttcg tcttttcgcg gatcgaccac caggcgcagg gtggcatccg
3669181 gcaaggccga gcgaatcaac cgggtgcaca cctcgtccac cgccaacctc aggtcggcca
3669241 cggcgtcgaa atccaggtcc tcgaaggtgc cgatggcgcc gaccagggtg cgcagcagcg
3669301 ccaggttctc caggcgggca gcaacgttca gctcgacggc gcggacaccg cgttggcgcc
3669361 ccttggtggg taaatccgag tcggccatgc accctcccgg caagcttcga tcgacagtac
3669421 tcccgccttg ggtctggtct tcgagctggt cggtcatggt cggacctgct ggtagtgggg
3669481 atctaacgca acatggtcgg gattcatcat ggtgtacccg tgatacccat tcgcagctgc
3669541 cggtgaaacc ccgcgatgcc gggatttcca gccgcactag gatgtctagc cggccagccg
3669601 ctgccgccgg acttcgggat gttcggtata ccagcgatcg gcaatcttgc gtatccgccg
3669661 atgctcgaac gctagccacg ccaaaccaac cactgtgacg acaatcgcca ccacaccaaa
3669721 ggtcatgccc tcggcgtgat gtccggtgcc gaaagccgca agagctccga cgccgccgac
3669781 gacaccggcc acaatcaaca gatacccagg ccaatgcacc acgtcgatca gcgactcgcc
3669841 ggcaagcggc cgcgtcgtcc gcaagtggtc gacggggtca cgataggtgt cgcccatggc
3669901 ctcctccgtt tccgtcctat tccgccattt ctgcccatta ccaggcacta ccatcaacgg
3669961 tagaactcgt cgaacgggtt gtggagggat ctgacccatt tatttgttga ccgcggccga
3670021 cctggccgac ggctcacggc gccatgaccg ggccggcgat cggtgggacg cctatgcaga
3670081 gcgtcagcac catcagcgtc aacaaaaacc agccggcgcc gtgccatccc caccaggtac
3670141 cttccgcacg ccatacccgg taggtgcgca gaaacgccca cagcccggcc gcacacagga
3670201 tcagcgggcc ccccagcgcc agcaggatcc gctggggcgg gccgcaggcc gcggtgtcga
3670261 cgccgctgca cgtgctgacc aacaacgctc ccataatgag gaaaccgacc ccgacgacag
3670321 cggccacaac agcaaaccga atcgccgagt gcacctcgct gtcatcccgg cctagccgat
3670381 cgccgcgtga cggcccacct acttcgtgca tcggcgaatc tccatcccgc tcttggcggc
3670441 tgccttacgt caccaccggt aacgcgctgc gcaccgcggc tatcgcggcg tcgatctcgg
3670501 cggttgaaac cgtcagcggt ggacggaatc gcacggtgtc tgcaccggcc ggcaacacaa
3670561 tcaccgcacg ttgccacagc tggcggatca actcgtcacg gtcggcggtg gtcggcaggc
3670621 taaacgcaca catcagcccg cggccgcgcg gatcgagaac cactgccggg aagtccgcgg
3670681 cgagttcgtc aagccgggcg cgcagatact taccgtgctg caccgcccgc tcgaacaggc
3670741 cctcggcttc gatgacctcc aagatgcggc gggcgcgcac catgtcggta agattgccac
3670801 cccatgtcga gttgagccgt gatgggaccg cgaacacatt gtcggcgacc tcgtccaccc
3670861 gccgaccggc catcactccg catacctgcg tcttcttgcc gaacgccacg atgtcgggtg
3670921 cgacatccaa ctgctggtat gcccaggcgg ttccggtcaa cccgcagccg gtctgtactt
3670981 cgtcgaagat cagcagtgca tcaaactcgt cgcacagctc gcgcatcgca gcgaaaaact
3671041 ccgggcggaa atggcggtcg ccaccctcgc cctggatggg ttcggccaca aaacacgcga
3671101 tgtcgtgcgg gcgggtctcg aatgccgcgc gggcctggcg tagcgcctcg gcctctagcg
3671161 cggccatagc gggctcatcc aggccgggcc gcatgtacgg cgcatcgatg cgtggccagt
3671221 cgaatttcgg gaaccgggcg gtaatggtcg gcttggtgtt ggtcagcgac agggtatagc
3671281 cgctgcggcc gtgaaatgcc ccgcgcaggt ggagcacttg agtgcccagc gccgggtcga
3671341 tcccatgggc ttggttgtgc cgactcttcc agtcgaacgc ggctttgagc gcgttctcca
3671401 ccgccagggc gcccccttcg acgaagaaca gatgcggcag cgccgggtcg cccaagacac
3671461 gggcgaaggt ctcgacgaag cgggccatcg ccaccgagta cacgtcggaa ttgctgggct
3671521 tgttcagcgc ggcctgcatg agttcggcat ggaactcccg gtcgtccacc agcgccgggg
3671581 gattcatacc cagtgccgag gaggcaacga atgtgaacat gtccaggtag cgccgacccg
3671641 ttatagcgtc gaccagatat gaaccgcccg aacgggtcag atcgagcact atgtccagac
3671701 cgtcgaccag catgctgcgc cctagcacct catgaacccg gtctggtgtt gttggtctac
3671761 cggcaagagc gacggacttc acgacggcgg ccatgacgct atgatagcag gatttacgga
3671821 atattgatat ttatgctgga aaaattatgg tatatgctgc ctatcgctgt aaaaagtgtt
3671881 cagaatgatc gtgcttcgcg tccgcacgtt cgccgttgtc cggatccgtt gcaacaggtc
3671941 ctcgagcgcc cgtgcggacg cgacgcgcac cagcaagacg tagctctctt cgccggccac
3672001 cgagtaacag gactcgacct cctcgatatg ttctaggcgc gcgggggcat catctggttg
3672061 agacggatca agaggagtga tagccacgaa cgccgacaac aaatgcccaa ccgcctcggg
3672121 attgattcgc gccgaatatc cctggaccac accacgagac tccagccggc gcactcgcga
3672181 ttggaccgcc gagaccgaca gcccggctcg cgtggccaac tctgacagcg tcgcacgtcc
3672241 gtcggcggcc agttcgcgca ccaggatccg atcgatatcg tcgagcgcct cgttcatggc
3672301 cggagactat cgcaacggca gtgccgcatg agccgctcga aaagactgca gactggccag
3672361 ctgcgcgcgc gcttcgccgc cgggttgtca gccatgtacg ccgctgaggt gcccgcctac
3672421 ggcacgctgg tcgaggtatg cgcacaagtc aactccgatt acctgacccg gcatcggcga
3672481 gccgagcggc tggggtcgct tcagcgcgtc accgccgagc gccacggcgc catccgagtg
3672541 ggcaacccgg ccgaactcgc tgcggtcgcc gacctgttcg ccgcgttcgg gatgctgccg
3672601 gtcggctact acgatctgcg caccgctgag tcaccaattc cagtggtgtc caccgcattt
3672661 cgcccaatcg atgcgaacga gctggcacac aacccgtttc gggtgttcac ctcgatgctg
3672721 gccatcgagg atcggcggta cttcgatgcc gacctacgca cccgagtgca gaccttcctc
3672781 gcgcgccggc aactctttga ccccgcgttg ctcgcccagg cgcgggcaat cgcggctgac
3672841 ggcggctgcg atgccgacga cgcaccggct ttcgtcgccg cggcggtggc cgcgtttgcg
3672901 ctgtcgcggg aaccggtcga gaaatcctgg tacgacgagt tgtccagggt gtcggcggtg
3672961 gccgctgata tcgctggagt cggctccaca cacatcaacc atctgacgcc tcgggtgctc
3673021 gacatagacg atctgtaccg tcggatgacc gagcgcggca tcaccatgat cgacaccatc
3673081 caaggccctc cccgcaccga cggacccgat gtgttgttgc ggcaaacctc atttcgcgcg
3673141 ctggccgaac cacgcatgtt tcgcgacgag gacggtaccg tgacgccggg aatcctgcgg
3673201 gtgcggttcg gtgaggtcga ggcgcgcggt gtcgcgctga ccccgcgagg gcgcgaacgc
3673261 tacgaagccg cgatggcggc cgcagatccg gccgcggtct gggccactca ctttccctcg
3673321 acggatgcgg agatggccgc tcaaggcttg gcctactacc gaggtggtga cccgtcagcg
3673381 ccgatcgtct acgaagactt cctgcccgct tcggccgcgg gcatcttccg ctccaacctg
3673441 gatcgcgact cgcaaaccgg tgacggaccc gacgatgccg gctacaacgt cgattggttg
3673501 gccggggcaa tcggccgaca cattcacgac ccgtatgcgc tctatgacgc gctcgcccag
3673561 gaggagcggc gctgataacc actgacgcgt tacgagccca ggtgctcgaa gcctgccaag
3673621 cgatcggcgt aaccgccgcc cttggcgagc cgggcgaaca cagcctgccc gcgagcacac
3673681 cgatcaccgg cgacgtgctg ttcagcatcg caccgaccac cccggagcag gccgaccacg
3673741 cgatcgccgc ggcggccgca acatttacgg catggcgaag cacgccggcc ccggtgcgcg
3673801 gcgcgctcgt ggcccggctc ggcgagctgc tcaccgcaca ccagcaggac ctcgcgacac
3673861 tggtcacagt cgaagtaggc aagatcaccg ccgaggcgcg cggcgaagtg caggaaatga
3673921 tcgacgtctg ccagttctcg gtgggtctgt cacgccagct ctacggccgc accatcgcgt
3673981 cagagcgcgc tgggcaccgg ctcctggaaa cctggcatcc gctgggagtg gtgggcgtga
3674041 tcaccgcgtt caacttcccg gtcgcggtct gggcgtggaa caccgcggtg gcactggtct
3674101 gcggcgacac ggtggtgtgg aaaccctcgg agctgacgcc gttgacggcg ctggcctgcc
3674161 aggcgctgct cagtcgggcc gccgctgatg tcggcgcgcc ggccgcggtg ggcggcctgc
3674221 tgttgggcgg cgccgagcgt ggtgcgcaac tcgtcgacga cccgcgggtt gcgttgttgt
3674281 cggcgacggg ttcggtgcgg atgggccagc aggtcggtcc acgcgtcgcc cggcgcttcg
3674341 ggcgggtgct gctggagttg ggcggcaaca acgcggccat tgtggcgccg tcggccgacc
3674401 tggagctggc ggtgcgcggc atcgtgttcg ccgcggccgg caccgcaggt cagcgctgca
3674461 ccagcctgcg ccggctgatc gtgcaccgct cggtggctga cgatgtggtg gcacgcgtcg
3674521 tcggcgccta tcgccagctg gcgatcggtg acccgtcggc cccggacacg ctggtaggcc
3674581 cactcatcca cgaggccgcc taccgcgaca tggtggcagc gctcgagcgg gcacgcaccg
3674641 acggcggcga ggtcatcggc ggtgatcgtc gcgaggtggg ctcaccgggc gcctactatg
3674701 tcgcgcccgc tgtggtccga atgccgtccc agaccgccat cgtggcgacc gaaacgttcg
3674761 caccaatcct gtacgtgctc acctacgacg acctcgacga ggcgatagcc ctcaacaacg
3674821 cggtaccaca agggctttcg tcgtcgatct tcacgaccga cctgcgtgag gccgagcact
3674881 tcctcgacca gtccgactgc ggtatcgcca acgtcaacat cgggacgtcg ggagcggaga
3674941 tcggtggtgc cttcggcggc gagaagcaga ccggcggcgg ccgcgagtcc gggtccgacg
3675001 cgtggaaggc ctacatgcgc cgggccacca acaccgtcaa ctactcgagc gagctgccgc
3675061 tggcgcaggg cgtgaagttc gggtaaccat gcccgtgggt gcgtctgggc atcatcgacg
3675121 cgcgcttggg gttgggcggg gtggaattca tccatttcat tcagtgcccg ttgcgaatcc
3675181 ccaagctacc ccgacggcga ccagaggatg tcgatgggga cggcggcgag gcggtcgccg
3675241 aatggctggg cttgtgggcc ggtgtgcagg atcacgccgc cggcgaagcg tgcgccgact
3675301 ttgtcgcgga gtctgctgat cgagcgggtg tctctaccac ggagggttgc cgccgacttg
3675361 atttcgatcg cggcaatgag gccgtctgcg gtttccagta tgaggtctac ttcggcgccg
3675421 tctcgatcgc ggtagtggaa cagtcgaggt gcctgttgcg accatccgag ttgtcgccgg
3675481 agttctgcga tcacgaaagt ttcgatgatg gctccggccg cgttggggtt ggcatgtgga
3675541 ccggctccgg taggcgagac attgacgagg cgagcggcca gtccggagtc gagaaggagg
3675601 actttcggtc tatcgacgac ccgcttggaa aggttggtcg accacgcggg tatgcggtcg
3675661 atgagataca gggtctcgag gaggtcgagg tacggcggca gggtacgtac ggggatttcg
3675721 gcgtcggtag ctagggagct caggttaagt tcggacgcgc tgcgtgcggc tagaagtcgg
3675781 atgaggcgcg gcaggtcggc gatgcgttgg agattggaga cgtcggccgc gtcacgtttg
3675841 acgacgcggt cgacgttcct agctttcgcc gattcgcgac aaagccgtcg ccgatacgcg
3675901 gcactatctt cgccaattcg cggatatctc ctcaccgatt cgcgatatct ggcggagccg
3675961 gtggtgtcgc agcagggacg tcggggcaga cccaccccac cgaaagaacc accaccacct
3676021 gctcgcctag ccgaacgtgt ggtctacgtg agtaatatct gtcacatggc gacagccaga
3676081 aggcggttat ccccgcagga ccgccgcgct gaactgctcg ctctgggggc ggaggtcttt
3676141 gggaagcggc cttacgacga ggttcgcatc gatgagatcg ccgagcgcgc tggggtgtcg
3676201 cgggcactga tgtatcacta cttcccggac aagcgggcgt tcttcgccgc ggtcgtcaag
3676261 gacgaggccg accggctgta cgcggcgacc aacaaggcgc ccgcccctgg gatgacgatg
3676321 ttcgaagaga tacgaaccgg cgtgctggcc tatatggcct accaccaaca aaaccccgag
3676381 gcggcgtggg ccgcctacgt cggcctcggc cgatcggacc cggttctgct cggtatcgac
3676441 gacgaagcca agaaccgcca gatggaacac atcatgtccc gcatcgccga ggtcgtgagc
3676501 gggattgacc gcgataacac cctggaccca gaggtcgagc gcgacctgcg ggtgatcatc
3676561 cacggctggc tggcgttcac cttcgagctg tgtcgtcagc ggatcatgga cccgtcgacc
3676621 gacgctgaac ggctcgccga tgcttgcgca cacgcgctgc tggacgccat ctcccggctg
3676681 ccgcagatcc ctgccgaact ggctgacgcg atggcaaccg cgcgaatgtg agcggtaggc
3676741 ggtttttgtc ggtgcctgtt ggcacgatgg ctaggtgagg ttcgcgcagc cttcagcact
3676801 gagccgattc agcgcgctca cccgagactg gttcaccagc actttcgccg cgcccaccgc
3676861 cgcccaggcc agcgcctggg cggccatcgc agacggcgac aacacgctgg tcatcgctcc
3676921 caccggatcc gggaagaccc tggcggcgtt cctgtgggcc ctggatagct tggccggttc
3676981 ggaacctatg tccgagcggc cggcggccac ccgcgtgctg tatgtgtcgc cgctcaaagc
3677041 gttggccgtc gacgtcgagc gcaacctgcg cactccgctg gccggactga cccgactcgc
3677101 cgaacgccag ggtctgcccg cgccccagat cagggtgggc gtccgttcgg gcgacacccc
3677161 gcccgcactt cgccgccagc tcgtcagcca gccgcccgac gtgctgatca ccaccccgga
3677221 gtcattgttt ttgatgctca cttcggccgc acgccaaact ctgaccggtg tgcagaccgt
3677281 catcatcgac gaaattcatg ccatcgccgc caccaagcgc ggcgcacacc tggcactatc
3677341 cctagaacgg ctcgacgacc tgtctagccg gcgacgggcg cagcgcatcg ggctgtcggc
3677401 gaccgtacgt cctcccgagg aactcgcaag gttcctgtcc ggacagtccc cgacgaccat
3677461 tgtggcgccc ccggccgcca agaccgttga gctgtccgtg caggtgccgg tgcccgacat
3677521 ggccaacttg accgacaaca ccatctggcc ggatgtggag gctcggctgg tcgacctgat
3677581 cgaatcacac aactcgacca tcgtgttcgc caattcgcga cgattggccg agcgacttac
3677641 cgcacggctc aacgaaattc acgccgcgcg ctgcgggatt gagctcgcgc cagacaccaa
3677701 ccagcaggtt gccggcggcg ccccggcgca catcatgggc tcgggccaga cgttcggagc
3677761 gccgccggtg ctggcccgcg cccaccatgg ctcgatcagc aaggagcagc gcgccgttgt
3677821 cgaagaggac ctcaaacgcg ggcaactcaa agcggtggtg gcgacgtcca gcctggagct
3677881 gggcatcgac atgggcgcgg tcgatctggt gatccaagta caggcaccac catcggtggc
3677941 cagcgggctg cagcgcattg gccgggccgg tcatcaggtc ggcgagattt cgcggggggt
3678001 gctgtttccc aagcatcgca ccgacctact cggctgcgcg gtcagcgtgc agcgcatgct
3678061 tgccggtgag atcgagacca tgcgggtgcc ggccaaccca ctcgacattc tggcccagca
3678121 cacggtggcg gcggctgcgc tggaaccgtt ggatgccgac gcgtggttcg acaccgtgcg
3678181 gcgggccgcc ccgttcgcga ccctgccgcg tagcctgttc gaggccaccc tggacctgct
3678241 gtccggcaag tacccatcca ccgagttcgc tgagctgcgg ccgcggctgg tgtatgaccg
3678301 cgataccggc acgctgaccg cgcgacccgg agcccagcga ctggccgtca cctccggcgg
3678361 cgccattccc gatcgcgggt tgttcgccgt ctacctcgct accgagcggc cgtcgcgggt
3678421 aggcgaactc gacgaggaaa tggtttacga gtcccgcccc ggtgacgtga tctcgctggg
3678481 tgccaccagc tggcgaatca ccgagatcac ccacgaccgg gtgctggtga tccccgcgcc
3678541 gggccagccg gcccgattgc cgttctggcg cggagacgat gccggccgcc ccgccgagct
3678601 cggcgccgca ctcggcgccc tcaccggcga gctggccgcc ctggaccgta cggcattcgg
3678661 cacacgttgt gcgggtttgg gtttcgacga ctatgccacc gacaacctgt ggcgactgct
3678721 ggacgaccaa cgcaccgcta ccgcagtggt acccaccgac agcacattgt tggtcgagcg
3678781 gtttcgtgac gagctgggcg attggcgggt gatcttgcat tcgccgtatg ggctgcgggt
3678841 gcacggaccg ctcgcgctcg cagtcggccg gcggctgcgc gaccgctatg gcatcgacga
3678901 gaagccgacc gcctccgaca acggcatagt ggtgcgccta ccggacaccg tgtccgctgg
3678961 cgaagacagc ccgccgggtg ccgaactgtt cgttttcgac gccgacgaga tcgacccgat
3679021 cgtcaccacc gaagtggccg gttcggcgct gttcgcgtca cggttccggg aatcggcggc
3679081 ccgcgctctg ctgctgcccc gccggcaccc cggccgccgc tcgccgctgt ggcagcagcg
3679141 gcagcgcgcc gcccggctgt tggaagtggc ccgcaaatac cccgacttcc cgattgtgct
3679201 ggagacggtc cgcgagtgcc tgcaggacgt ctatgacgtc ccgatcttgg tcgagctgat
3679261 ggcgcggatc gcccagcggc gggtgcgtgt cgccgaagcc gagaccgcca aaccttcgcc
3679321 atttgcggca tcgctgttgt tcggctacgt cggcgccttc atgtacgagg gcgatacgcc
3679381 gctggccgaa cggcgcgccg ccgcgctcgc gctggacggc acgttgctgg ccgagctgct
3679441 aggccgggtg gagctgcgcg agctgctcga tcctgacgtc atcgccgcta ccagccgcca
3679501 gctccagcat ctggcggccg accgggtagc ccgtgacgcc gaaggggttg ccgatctgct
3679561 gcggctgctg ggtccgctca ccgaagacga gatcgctgcc cgggcgggcg cgcccgaggt
3679621 cagcggctgg ctggacggct tacgcgccgc caaacgcgcg ctcgtggtgt ccttcgccgg
3679681 ccgcagctgg tgggttgccg tcgaggacat gggccggctg cgcgacggcg ttggcgcggc
3679741 ggttccggtg gggctgccgg ccagcttcac cgaggcggta gccgacccgc tgggcgaact
3679801 actgggccgc tacgcacgca cccacacacc gttcaccacc gctgcggccg cagcccggtt
3679861 cggtcttggg ctgcgggtga ccgccgacgt gctgggccgg ctggccagcg atggccggct
3679921 ggtgcgcggc gaattcgtgg ccgcggccaa aggatccgcc ggcggcgagc agtggtgtga
3679981 cgccgaggtg ttgcgaattc tgcggcgccg ctcgctggcc gcactgaggg cgcaggcaga
3680041 gccggtcagc accgccgcct acggacgctt cctgccggcc tggcagcacg tttccgcggg
3680101 caactcgggc atcgacgggc tggccgcggt catcgatcag ctcgccggcg tccggatacc
3680161 ggcctcggcg atcgaaccgc tggtgcttgc cccacggatc cgcgattact cgccggcgat
3680221 gctcgacgag ctgctcgcga gcggggacgt cacctggtcg ggcgccgggt cgatctcagg
3680281 cagtgacggc tggatcgccc tgcaccccgc cgactcggcg cccatgacgc tggcggagcc
3680341 ggccgagatc gacttcaccg acgcccaccg ggcgatctta gccagcctgg gcactggcgg
3680401 cgcgtacttc ttccgccagt tgacccacga cggcctgacc gaggcggaac tcaaagccgc
3680461 tctgtgggaa ttgatttggg ccggacgagt gaccggcgac acgttcgcac cggtacgcgc
3680521 ggtactcggc ggggcgggca cccggaagcg tgctgctccc gcacacggcg ggcatcgacc
3680581 gccgcgcctg agccgatacc gcctcacgca cgcccaggcc cgcaacgctg acccgaccgt
3680641 cgccgggcgg tggtccgcgc tgccgcttcc cgaaccggac tccacgctgc gcgcccatta
3680701 ccaagccgag ctgctgttga accgccacgg cgtgttgacc aaagacgcag ttgctgccga
3680761 gggtgtggcg ggcgggttcg cgacgctcta caaggtgctc agtgcgttcg aggatgccgg
3680821 caggtgccag cgtggctact tcatcgagtc gttggggggc gctcagttcg ccgtcgcctc
3680881 gaccgtagac cggctgcgta gctacctcga cggtgtcgac cccgaacagc cggactacca
3680941 cgcggtggtg ctggccgctg ccgacccggc caacccgtat ggggcggcgt tgccctggcc
3681001 agcgtcgagc gctgacggta ccgcccggcc gggccgcaaa gccggcgcac tggtcgttct
3681061 ggtggacggc gagttggcct ggttcctcga gcgcggcggg cggtcgttgc tgacgttcac
3681121 cgatgatccc gaggccaacc acgcggcggc catcgggctg gccgacctgg tcaccgccgg
3681181 gcgcgtcgcg tcgattctgg tcgagcgggc cgacggcatg ccggtgctgc agcccggcgg
3681241 gcgggcgtcg gcggcactga cggcgctgct ggcagccggc ttcgtccgca cacctcgcgg
3681301 tctgcggcgg cggtaagcca tgcccgaggg cgacaccgtc tggcacaccg cggccacgtt
3681361 gcggcggcat ctggccggtc gcacgttgac acgttgcgac atccgagtgc cacggtttgc
3681421 cgccgtcgac ctcaccggcg aggtagtgga cgaggtgatc agtcggggca agcacctgtt
3681481 catccgaacc gggacagcca gcattcattc gcatctgcag atggacggca gctggcgggt
3681541 cggcaacagg ccggtgcggg tggatcatcg ggcgcgaatc attttggaag ccaaccagca
3681601 agaacaggcc atccgggtgg tcggcgtcga cctaggcctg ttggaggtca tcgaccggca
3681661 caacgacggc gccgtcgtcg cacacctagg acctgatctg ctggccgacg attgggaccc
3681721 gcagcgtgca gccgccaacc tgatcgttgc cccggaccgg cccatcgccg aggcactgct
3681781 cgaccagcgg gtgctcgccg ggatcggcaa cgtgtattgc aacgaactgt gcttcgtcag
3681841 cggagtattg ccgacggccc cggtgagcgc ggtcgccgac ccgcgccgcc tggtcacccg
3681901 cgcccgagac atgctgtggg tcaaccgctt ccgctggaat cggtgcacca ctggcgatac
3681961 ccgggccggc cggcgactgt gggtctacgg gcgggccggg cagggttgcc gccgctgcgg
3682021 cacgctcatc gcctacgaca ctaccgacga gcgggtgcgg tattggtgcc cggcctgcca
3682081 gcgctgaacc gggcgatcaa agccagcacc tagtcgcggc cgtgggtagc gaagaactgg
3682141 gcaatgactt gcgacccgtc gaacgcgcgc gtggtcgccc cgatgaccgc cttgggcaga
3682201 tattgcctgc cacccggcca ggtatgtccg ccattgtcga tctggtagga gatcacctcg
3682261 gtgccggccg cacatgagct ggaatcgaaa aggtgcacca ttgttccgtc cccgacgtca
3682321 ggcagctccg ccgccgacgg atcgccctga cacccatcga ccgcccgcca gcgatccacc
3682381 aagctcgcaa ccgagatgga atggctgagc ccgccgcgac cacgcaccgc cccgccgttg
3682441 aacggcacca gcgggtcggc ggtgccgtgt gcttcgagca ccgacaccgg ccgcgacgga
3682501 ttacatgtca cacccacacc cagcgtgccc gccaccggcg cgaccgcggc gaagatatcg
3682561 gcacggtcac acgccagccg gttggacatg aagccaccgt tggacatgcc ggtggcgaag
3682621 acgtgcccgg gagcgatgtc gaagtcgtgc accagctttg cggccagcgc gaccaagaac
3682681 ccaacgtcgt cgagatgacg gcgatccgcc ggcgacgccc ccctcccgtc ggcccagctt
3682741 ttgtcgtagc cgtcaggata gacaaccaac aagtcggcgg cgtcggcaac agcgtcgaaa
3682801 tcggtgagag cctcctgtcc ggctccggtg ccgccaccac cgtgcaggct gatcaccaac
3682861 ccggagggct cagcgggcgg cacgtgcaag cgataactgc gggtcaagcc cccgaactgg
3682921 aacgtcgcta ccgaactggc atgcctggcc agtagctgat caccgccaca cccggccagg
3682981 caaaccatga gaacgataag cgacagcatt cgcgcccacg gcatctcgtc aaggtaccga
3683041 tcgcgagcgc tcagcccgcg gcgccctgtc ccaccgcttg gaccgatgcg tgctcgtgca
3683101 acgccctggc ggcttcggga tgtacgggct tgaggtcgaa gatgacctcg gtgacggtcc
3683161 cggtgaacgc atagggcgcc ttgtcctcat agccgcggtc aacgaccagg ccgttgtcgc
3683221 ggccgatgtc catgccggca taggaggtaa aggccagcgg caccgtctgg ggcagctcac
3683281 cctctccgat caaccgatcg tcggcccaga gcgtcacccg accaccggag gcggcgacgg
3683341 gttgatggga atcgaacagc atccgcaccg tgacatcccc ggtggggagc ggctcgctgg
3683401 acacctgccg gtaggtttcg acgcccagga aggagtaggt gtggtgcagg tgccgctgtt
3683461 cgtcgaccca tagcgcgaac cctcccatga agtcggcgtt ggcgacgatc acaccctgcg
3683521 cgccgccgtc ggggatgtgc agccgtgcct cgatcgcgta agaacgaccg cagatacggg
3683581 ggaccatgcc gcgctgaatg ttctgcacgt cacctttgaa actgaaccgt gcggtggtgg
3683641 gcaggggcgg caggtcgccg aacattaccg cgagcccgcc cagcagcggc agcacccggt
3683701 ttcgttcggc ctcctgccac cacagctggg tgagctcggc gaccttgtcg ggatgctcgg
3683761 ctgccaggtt tttcgcctgg gagaagtcat ctggtaggta gtacagctcc cagacgtcct
3683821 ggtccgggtc gtaggtcccc ggcgcgaacc gtcgcatcgt ctccggtgac agatcccagg
3683881 gcgccttgtc caagcgagcg cacgcccacc agccgtcttt gtagatggca cggctgccga
3683941 agttttcgaa gtactgcacg gtgtggcggt cttcggcttc agcgtcgtcg aaggtccgca
3684001 cgaaactggt tccgtccatc ggttcctgct cgaagccgtc gacatgggtc ggctccggta
3684061 aaccgatggc cgccaacacg gtcggcgcga tgtcgatgca gtgggtgaac tggctacgaa
3684121 cacggccgtc tggccggatc cgggccggcc aagcgaccac caatggatcg cgcgtgccgc
3684181 ccaggtggct ggccatctgc ttgccccact gcaacggggt gttgctcgca tgcgcccacg
3684241 cgctggcgaa atgcggtgcg gtgaactcgt cgccgagtgc ggcgatgccg ccgtattgtt
3684301 cgatcagctc caattgccgc tcggcatcca gatccaggcc gttaaggaac gtcatctcat
3684361 tgaacgaacc ggtgttggtg ccctccatgc tggcgccatt gtcgccccag atgtagaaca
3684421 ccaacgtgtt gtcggactcg ccgagatcct cgatcgcgtc cagcagccgg ccaacattcc
3684481 agtccgcatt ttccgagaac ccggcgaaca cctccatctg gcgggcaaag agccgttttt
3684541 gcgcctccga catactgtcc cacgcgggga ataggtcggg ccgctcggtg agttcggcgt
3684601 cgggtggaat gatcccgagt cgcttttgcc gttcgaatgt cttctgccgg tacacatccc
3684661 agccatcatc gaactcacct cggtacttgt cggcccattc cttgaatacg tggtgtggcg
3684721 cgtgggtggc gccggtcgcg tagtacagca tccacggctt ggtggcattc tgggcccgca
3684781 cggtgtgcag ccactcgata gccttgtcgg tgaggtcgtc ggggaaatag tagggacggc
3684841 cgtcttcccc agaaccctcg ggtatgccta tgacggagtt gtcctgactg atgatcgggt
3684901 cgtactgacc cgcggcgccg ctcgggaagc cccagaaatg gtcgaatccc caacccagcg
3684961 gccagttgtc gaacggcccc gcggctccct ggacattgtc cggggtcaga tgccacttgc
3685021 cgaaagcgcc agtcacataa ccgttgtcgc gcagaatacg cggcagcgct gcgcaactgc
3685081 gtggcctgac cgccgaatac cccgggtacg ggccggggaa ctcgcagacc gacccgaagc
3685141 ccacccggtg atggttacgc ccggtcaaca gcgccgcacg ggtcggcgag cacaccgcgg
3685201 tcacatgaaa acggttgtag atcaacccat tctgggctag ccgggacagc gtcggggttc
3685261 ggatcgcgcc gccgaatgta tccggtccgc cgaacccagc gtcatcgatc aacacgatca
3685321 gcacattcgg tgcgtcgtcg ggcggaaagg gaccggggac aatcgaccag tcgccgaccg
3685381 actctgccat ggtgcggcca accacgccac caaagcggcg ctgcggtagc ggcagccggg
3685441 tgcggtctgg gttgaacttg cccatcgcct ctcgcaacgc cgcacccagg cttcgcaacg
3685501 tcgaacgact cagctccgca accgatttca ttggagagct agccaacgcc tgccccgctt
3685561 ccagtcggcc ttgtgcctcc gtcacggcga tgaccactgc tcggcccgcc gccagcgctt
3685621 ggccgatctt gtcggccagc ccggtcttga tccgatggtg ggcgaaggtg ccggccaatg
3685681 ctccggtcgc ggcgccgagc gccgccgagg ccaacagtgc cggcgagaac aggccgatcg
3685741 ccaggcccac cccggcgccc cacgcggcgc cgcgccggcc gagccgattt ccggtgtcga
3685801 ccaaaaccgg actgccctcg gcgtccttgc cgatcagcac cgcaccctgc agcggaatgc
3685861 ttttgtcctt ggcggcatcg acgagggttt gaaaatcgtg acgagccgaa tcgaggtcct
3685921 gatagccggc gacgagcacc agcgcgttgt cttcactcat cacgaaactc ccgatatgtg
3685981 tgtcacggcc ggcaatcggc cgcggctgac catgttggca acgtagcacc ggtcaacgtg
3686041 cgcgtgctgg cgaactcgcg gtgcgacccg gtcagcggat cgtcgaactc gatgcgctgc
3686101 gcgagcaact gcagcggtgt gctgaagtcg tgggcggcca cggatatcac gttggggtac
3686161 aacgggtcac ccatgatcgg tatccccagc gccgccatgt gcactcgcag ctggtgggtg
3686221 cgcccggtgg tcggtgtcag ccgatacaga ccgtcgcgcg ctatccgctc caccagcgtc
3686281 tccgcgttgg gaacgccggg ctcacagacc gcctgcagat ggccccggcg cttgacgatg
3686341 cgactgcgga ccaggcgcgg cagggccaga cccggggcaa cgggtgcgcg agccagatag
3686401 gtcttgcgca ccaaaccgcg ggcgaacatc gtctggtagc tgccgcgcac ctcgcgtcgg
3686461 gtggtgaaca acaacacccc ggcggtcagc cggtccagcc ggtgggccgg gctcagctcg
3686521 ggcaatccca gttcgcgacg cagccgcacc agcgcggtct gcgcgacgtg tcgcccccga
3686581 ggcatggtcg ccaagaaatg tggcttgtcg acgacgacga tgtcggcgtc ttgatgcagc
3686641 actgggacat cgaagggcac cggcacctcg tcgggcaggt cgcgatacag gtgcacaacc
3686701 gaaccgggcg gcagcaccgt gccactgtcg accaccgcac cgtcgtcgtc gaccacctcc
3686761 ccggccagca ccttcgcacg ggccgccacg ccaaaccgtg cggtcagctc ggctaacacc
3686821 gacccgccaa gcagtcgcac ccgcaccggc cccagcacgt cgtgcacgct aagcaaacga
3686881 tcctctggcc gcaacgccac acgagaccct ctcagtaagt ggaaatctcg tcctcggtcg
3686941 gtagcacccc ggtgaccatg aagatgacgc ggcggcccac ttccacagcg tggtcggcga
3687001 agcgctcaaa gaaacgaccc agcaacgccg tttccacacc gacgcgaacg ccgtgccgcc
3687061 attctcgatc tatcagcacg ctcagcaaat gcctatgcag gtcatccatc gcgtcgtcac
3687121 gatcgtgcag ttgcgcggct tcctgcgggt cacggttcac cagcacttgt cttgcactgt
3687181 cacccaacgc gattgccacc ttcgccatgt cggcgaagca gttgcgaact tcctcaggaa
3687241 gcacctggtt cggatactcg cgtcgggtga tcttggcaat atgcacagcc aacgcaccca
3687301 tgcgctcggt gtcggcgatg atctgcaccg cactgaagat ttcccgcagc tcgccggcca
3687361 ccggatgttg caacgccagc agcgcgaacg cttccttttc gacttgggct cgcatcgcca
3687421 cgatccgctc atggtcacgg attacttgtt cagcggcgcc aatgtcggcc tcgagcagag
3687481 cctgcgttgc gcgtttcatc gctatcccgg ccaggctgca catctctccc aatcgtccgg
3687541 ccaactcggt tagccgctgg tgatagaccg tccgcatggt gtcacgcctc tctgaccctg
3687601 agtcgtcgtg tggtgctgcc gcggatccac accgccatca tcgaccatgg cggcaccgcg
3687661 cgacataccc gcttggcgta gccttcaatc caaaggcacc ggctcgagga tctcggcacg
3687721 cgcctcgggt gcgctggccc gcaacatgtc cgccgaaacg tcgtcgggct gggcctggga
3687781 gagcacctcg gcctccacgc gcgccatata gttcgcgacc tcgcggtcga tgtctgcggc
3687841 ggtccacccg agcacgggcg cgaccacctc ggccacctcc cgggcgcagt cgacgccccg
3687901 gtgcgggtat tcgatggaaa tccgcatccg acgggccagg atgtcctcga gatgcagggc
3687961 gccctcggcg gcggcggcgt aagcggcttc caccttcaaa tagcccggtg cctccgttat
3688021 cgggctcaac aggctgggat cggaggccgc catcgctaga acgtcgctga tcagcgaacc
3688081 atagcggtcc agcagatggc gcacccggta cgggtgcagg ccctgcagcg cgccgacgtg
3688141 ttcggcctga ttgaccagtg caaagtaacc gtcggcgccc agcaggctga ccttctcggt
3688201 gatcgacggc gcaacgcggg cggggatgaa ctgcacagca gcgtcgatcg cgtcggccgc
3688261 cattactcgg taggtggtgt acttgccacc ggcgatggcc accaggcccg ccgccggcac
3688321 agccacggcg tgttcccggg acagcttgga ggtgtcgtcg ctttccccgg caagcagcgg
3688381 ccgcagcccg gcgtacactc cgtcaatgtc ggcgtgcgtc aacggggtcg ccaacacggc
3688441 gttgacagtg cccaggatgt agtcgatgtc ggccttggtg gccgcggggt gcgccaggtc
3688501 gaggttccag tcggtatcgg tggttccgat gatccagtga cttccccacg gaatgacaaa
3688561 catcaccgac ttctccgtgc gcaggatcat cgcgacgtca ctgacaatcc ggtcccgcgg
3688621 caccaccaca tgcacgccct tggatgcgcg cacctggaag cgcccgcgct gtttggacaa
3688681 cgcttgaatc tcatcggtcc agaccccggt cgcgttgacc acgacgtggc cgcgaacctc
3688741 ggcaaccgcg ccgttctcgg agtcgcggac gcccacgccg atcacccggt caccctctcg
3688801 caacaaggcc actacctggg tggagcagcg gacaaccgcg ccgtaatgcg ccgcggtgcg
3688861 cgcgaccgtc atggtgtgcc gggcgtcgtc gacgacggtg tcgtagtaac ggataccacc
3688921 gatcagcgag ctgcgcttca agccggggct cagtcgcagc gcaccggcgc gagtaaaatg
3688981 ccgttgcgcc ggaaccgatt tcgcgccacc cagccggtcg taaagaaaga tacccgcggc
3689041 gatgtaggga cgctcccacc agcgtttggt cagcgggaac aaaaacggca gcggcttgac
3689101 caaatgcggt gccagcgtgg tcagcgacag ttcacgttca tagagcgcct cacgcaccag
3689161 cccgaactcc agttgctcga ggtagcgcag cccgccgtgg aacatcttcg aggagcggct
3689221 cgacgtgccg gaggccaagt cccgcgcctc gaccaacgcc accttgagcc cacgggtggc
3689281 agcatccaaa gcgcatccgg agcccactac tccgccgccg atcaccacga cgtcgaattg
3689341 ctcggttccg agtcgcttcc aggcgaccgc gcgctgtgca ggtcccagcg ccgcggcggg
3689401 ccacccctgc ccgccgtccg gtgcctggat tgggttgctc acgaaaccgg ctcctgtcag
3689461 ttactcgtcg gtaggtggtg tggcaccaag gctagttgtt cagccgcgtc ttgagctgcc
3689521 gtgcagtcca gatcgtcgtg cgccatcagc cggcgggccg cctcggttat cgaacccgac
3689581 aacgatgggt aaacggccag tgtctgggcc agctcgttga cggtgatgcg gttctgaacg
3689641 gctacggcga tgggcaggat cagctccgat gcgatcggcg ccaccaccac gccgccgatc
3689701 acaacgccgg tggaccgccg gcagaagatc ttgacgaacc cgtgacgcat ctccgacatc
3689761 ttggcgcgcg cgttggttcg taacggcagc atgatggtcc gggcggccac cgaaccggcg
3689821 tcgatgaccg attgcggcac cccgaccgcg gcgatctcgg gcctggtgaa aaccgtcgcg
3689881 gccaccgtgc gtaaccggat cgggctgacg ccctccccca gcgcgtggta catcgcgatg
3689941 cggccctgca ttgcggcgac cgacgccagg ggcagcaaac ccgtgcagtc gcccgcggcg
3690001 tagatgccgg tcgccaacgt ccgcgacacc cggtccacgg tcaggtaatt gccccggcca
3690061 agctggatgc cgacccgttc caggcccagg ccgctggtgt tgggcaccga cccgatggtc
3690121 atcagggcgt ggctgccctc gacggtgcga ccgtcggtca tcgtgacgag caccccggcc
3690181 ccggtgcggg tgaccgatgc tgcccgggca tttttgaaca gccggactcc ccgttcggcg
3690241 aacgactctt ccaggaccag cgcagcgtca gcgtcctcat acggcagcac gtggtcctgg
3690301 ctggccacca ccgtgaccgg cacccccaat tcggtatagg cgtccacgaa ctcagcaccg
3690361 gtaaccccgg agcccaccac gatgaggtgg tcgggcaacg cgtccaagtc gtagagctgc
3690421 cgccaggtca gaatgcgctc accgtccggc tgggccgacg gcaggatccg cgggctggcg
3690481 ccggtggcga ccagcacgac gtcggcctca tgctcactgg tggagccgtc ggcggcggtc
3690541 gccttaatgc gatggcgcgc cagacccggt gtggagtcga tcaactcgcc ccggccggcg
3690601 atcacctgaa cccccatgct gagcagctgg gcggtgatgt cggccgactg tgcggcggcc
3690661 agcgtcttga cccgggcatg gatttgcggc aacgagatct tggcgtcgtc gaagtcgata
3690721 tgaaagccca ggtgcggcgc tcggcgcagt tcggtacgca gcccggtgga ggcgatgaac
3690781 gtcttcgacg gcacacagtc gtccagtacg gcagccccgc cgatgccgtc gcagtcaatc
3690841 acggtaactt gggttgtttc cgggtgtgag gtggcggcca ccagtgcggc ctcgtaaccg
3690901 gccgggccgc caccgaggat cacgatgcgg gtcaccacag cccataacct agctcggcga
3690961 cgatgcacgc cgcgcagcgg cgtgaggagg agccgagcag tccaacacag ctcggcgacg
3691021 atgcacgccg cgcagcggcg tgaggaggag ccgagcagtc aagcacagct tgacgatgac
3691081 ccgcaccgca gcgcggcgcg atgggtacca cccgagcccc cgccgtctaa gctttccccc
3691141 gtgccgctct acgccgccta cgggtcgaac atgcatcccg agcagatgct cgagcgcgca
3691201 ccccactcgc cgatggccgg aaccggctgg ttacccgggt ggcggctgac gttcggcggc
3691261 gaggacatcg gctgggaagg ggcgcttgcc accgtcgtcg aagacccaga ttcgaaggtg
3691321 ttcgtcgtgc tctacgacat gaccccggcg gacgagaaga accttgaccg gtgggaaggc
3691381 tccgagttcg gcatccacca gaagatccga tgccgcgtgg agcgcatttc ctcggacacc
3691441 acaacggatc ccgtcctcgc gtggttgtac gttttggacg cctgggaggg tggcctgccg
3691501 tcggcccgct atctaggtgt gatggccgat gccgctgaga tcgcgggcgc gccaagtgat
3691561 tacgtacatg acttgcgtac tcgcccggcc cgcaacatcg gcccgggaac tattgcctaa
3691621 ttatcgcgag cgcccaggct aatgcgcggc ggcctgctcg atgatgttga ccatcacccg
3691681 cagcccgatc gccagggctc gctcgtcgat gtcgaacgtc ggctgatgca ggtccaactg
3691741 cagtccgtca ccggaccaca cgcccagtcg agccatcgcg ccgggaacct cctccaaata
3691801 ccaggagaag tcctcaccac cgccggactg ccgggtatcg gccagcacac ctgggccaat
3691861 agcctcaata gcgtgggcga gaatgcgtgt cgagatttcc tcgttgacca ccggcggcac
3691921 cccccgacgg tattgcagcg tgtgctcgat cgccaacggt aatagcaacg ccgaaatggc
3691981 ttggcggaca agctcctcaa ggtcaaccca ggtctgccgg ctggccgtgc gaacagtgcc
3692041 ggacagaact ccggtttgcg gaatggcgtt ggcggccata cccgcgttga ccgcgcccca
3692101 caccagcacg gtgctgttac gtgggtcgat gcgacgcgac agcaccccgg gcagcccggt
3692161 gaccagcgtg ccgagcccgt agacgaggtc ggcggtcaag tgtggacgcg acgtgtgccc
3692221 gcccggcgaa tacagcgtga tttctatcga gtcggccgcc gacgtgatgg ggccttgccg
3692281 aacggcgacc ttgccgactt caagccgggg atcgcagtgc agggcgaaga tccgcgacac
3692341 cccggccaac gcgccggccg cgatcgcgtc gatggcacca ccgggcatca gttcctcggc
3692401 cgcctggaag atcaaccgca cccccaccgg cagctccggt accgaagcca atgccaatgc
3692461 ggcacccagc aggatcgcgg tgtgcgcatc atggccacaa gcatgcgcga cgttgggcat
3692521 ggtcgaggcg tagggcgcgc cggtccgctc ggccatcggc agcgcatcca tatcggcgcg
3692581 cagcgcgatc cgcggctgat gctgaggacc gaagtcgcag gtgagtcccg ttccaccggg
3692641 cagcaccttg gggttcagcc ccgcgtcggc taaccgctcg gcgacgaact gggtagtggc
3692701 gtattcctga cggcccaact ccggatagcg gtggatgtgc cggcgccagc cgaccaggtc
3692761 gtcgtggtgg gcggctagcc atgattcggc ggcgtcggcg aggctcatcg cgccgccctg
3692821 cgctgctgcg cggccagcac ccggtcacgc tcatcaggag tctgcgcgag acggacaacc
3692881 gtgcgtgcca acatgatcgc gccgtcaacc accgcgcggt cggcgctggc accagcggaa
3692941 gcgacggtga aggcccgttg gtgcaccgtc gccgcgccgg cgtccaggcc gatcaccgga
3693001 tggatcccgg gcagcacctg cgtcacgttg cccatgtcgg tgctacccag cggcagctct
3693061 gcctccaagg ctggcagcaa cggctcgcgc cccagccgct gcatctcctc ccggcacacg
3693121 tcagccagcc acgggtcggg tttgagctcc gcgtatgccg gtgcagcctc gtcgatttcg
3693181 tattcgcacc cggcggccag cgcgccggcc gcaaagcagg cgaacattct ggtctgcagc
3693241 tcgcgcagcg aatccgattc gaccgcacgc atcgcatact gcagcctcgc ctgcccgggg
3693301 atgacattga ccgcctgccc gccgtcggtc acaatgccgt gcaccatttg cccgggcgcc
3693361 aattgctgtc gaagtacccc aatagcgacc tgcgccacgg tcacggcgtc ggcggcgtta
3693421 acccctaggt gcggcgcgac ggccgcgtgc gattccttac cccgatagcg cacggtgacc
3693481 tcggacaggg ccagtgatcg tgcgccggcg atatcggtcg gcccgggatg gaccatcacg
3693541 gccaccgcaa cgtcatcgaa cgtcccggcc tgcagcatca gcgccttacc gccgccggac
3693601 tcctcggcag gggtccccag cagagccacg gtcaagccca ggtcgtccgc cacctcagcc
3693661 agtgccagcg cggtgcccac agcggaggcc gcaataatgt tgtgcccgca ggcgtgtccg
3693721 atcccgggaa gcgcgtcgta ctcggcgcac actccgacaa ccaacggtcc gctgccgtag
3693781 tcggcgcgaa acgccgtgtc caacccaccg gcggccgtgg tgatctcgaa accgcgttcg
3693841 gcgaccagcg cctgagcctt ggcgcagctg cgatgctcgg cgaacgccag ctcgggctcg
3693901 gcgtggatgg catgggacag ctcgaccagc tcgccaccac ggcgccgcac caattcctcg
3693961 acgcggtcgg atgcgctggc tgctggcatg ctcgcagtat ctcatcgacg agcacccgct
3694021 ccccggcgag cggctcagtt aagctcgccc agtgtggctg acccgcgccc cgatcccgac
3694081 gaactggccc ggcgggcggc gcaggtcatc gctgaccgca ccgggatcgg cgaacatgac
3694141 gtcgcggtcg tgctcgggtc gggatggtta ccggccgttg cggcgttggg ctccccgacc
3694201 accgtgctgc cgcaggccga actgcccggg tttgtgccgc caaccgcagc cgggcatgcg
3694261 ggcgagctac tgtccgtgcc catcggtgcg caccgggtgc tggtgctggc cggtcgcatc
3694321 cacgcctacg agggacacga cctgcgctac gtcgtgcatc cggttcgggc ggcccgtgcg
3694381 gcaggggcgc agattatggt gctcaccaac gccgccggtg ggctgcgggc ggaccttcag
3694441 gtcggccagc cggtgctgat cagcgatcac ctgaacctga ccgcacgttc gccactggtt
3694501 ggcggggagt tcgtcgacct gaccgacgcc tactcaccgc gactgcggga actcgcccgc
3694561 caatccgacc cgcagctggc cgaaggcgtc tacgccggcc tgccggggcc gcactacgag
3694621 acaccggcgg agatccggat gttgcagaca ctgggcgccg acctggtcgg catgtccacg
3694681 gtgcacgaga ccatcgcggc ccgggcggcg ggcgctgagg tactgggcgt atccctggtg
3694741 acaaatctgg cggccgggat caccggcgag ccgctgagcc acgccgaggt gctcgccgcc
3694801 ggagccgcat cggcgactcg gatgggcgcg ctgctagccg acgtgatcgc ccggttctaa
3694861 gccgtgacgc cagagaattg gatcgcccac gacccggacc cgcagacggc cgccgagctc
3694921 gccgcctgcg gccccgacga gctgaaagcg cggttcagcc gcccactggc gttcggcacc
3694981 gcggggttgc gcgggcacct gcggggcggg ccggacgcga tgaacctggc ggtggtgttg
3695041 cgcgccacct gggcggtggc acgggtgctc acggatcgag gtctggctgg ttcgccggtg
3695101 atcgtggggc gcgacgctcg gcacggctca ccggcgtttg ccgctgcggc cgccgaagtg
3695161 cttgccgccg caggtttttc cgtgctgctt ctgcccgatc ccgcacccac cccggtggtg
3695221 gcgttcgcgg tgcggcacac cggcgccgcc gctgggatac agatcacggc gtcacacaac
3695281 ccggcgaccg acaacggcta caaggtctat gtcgacggcg gccttcagct cctcgcccct
3695341 accgaccggc agatcgaagc cgcgatggcc accgcgcccc cggccgatca gatcgccagg
3695401 aagaccgtca accccagtga aaaccgcgcc tccgatctga tcgaccgtta tatccagcgt
3695461 gcggccgggg tccgaaggtg cgccggttcg gtccgggtgg ccctgacgcc gctgcacggg
3695521 gttggcgggg cgatggccgt cgagaccctt cggcgagccg gtttcaccga ggtgcatacc
3695581 gtggcgacgc aattcgcgcc gaatcccgac ttccccaccg tgacattgcc gaaccccgag
3695641 gagcccggag ccaccgacgc actgctcacc ctggctaccg acgtggacgc cgacgtcgcg
3695701 atcgcgctgg atcccgatgc ggatcgctgc gcggtcggga tacccacggt gtcgggatgg
3695761 cggatgctgt ccggtgacga aaccggttgg ctactaggtg attacatctt gtcgcaaacc
3695821 gacgaccggg cgtcgccgcc ggaaaccagg gtggtggcca gcaccgtggt gtcgtcgcgg
3695881 atgctggcgg cgatcgccgc gcatcacgct gccgtgcacg tggagaccct caccggcttt
3695941 aagtggctgg cgcgcgccga tgcgaacctg cccggcaccc tggtgtacgc ctacgaggaa
3696001 gcgatcgggc actgcgtcga ccccaccgcg gtgcgtgaca aagacggcat cagcgccgcg
3696061 gtgttggtgt gcgatctggt ggccgcgctc aaaggccagg gtcgttcggt gaccgacgcg
3696121 ctcgacgagc tcgcccgatg ctacggcgtg catgaggttg ccgccctgtc acgccccgtg
3696181 agcggcgccg tcgagaccac cgacctgatg cgacggctcc gcgaggaccc gccgcgtcgg
3696241 ctggccggtt tccccgccac ggtcaccgat atcggcgaca cgctgatcct caccggcggc
3696301 gacgacaaca tgttggtcag ggtggcggtg cggccttctg gaacagaacc gaagctgaag
3696361 tgctacttgg agattcgctg cgcggtgacc ggtgacctac cagctgcccg acagctggtg
3696421 cgggcgagga tcgatgagct gtcggctagc gtgcggcggt ggtggtgact cagcgcgggc
3696481 cgaactggcg atcgccggca tcgccgagac cgggcacaat gtaggcgacc tcgttaagcc
3696541 cttcgtcgat ggccgcagtg aacaaccgca cgtttggcgc agccttctgc agcgccgcga
3696601 ttccttctgg cgccgcaacc acacacagca ccgtgatatc cgctgcaccg cgcgagatca
3696661 gcagaccgag ggtgtgcgtc atcgacccgc cggtggccac catcgggtca agcaccatga
3696721 ccggtacatc cgtcaggtcg tcgggcagcg agtccagata cggcaccggc tggtgggttt
3696781 gctcgtcgcg ggcgacaccg acaaagccaa cgtgcgcctc cggcaaggcg gcatgcgcct
3696841 cgtcgaccat ccccaacccc gcccgcaaca caggaaccag caggggtggc ttggttagcc
3696901 gcgacccgac cgtctcggcc agcggcgtac ggatcgggac tggctcgcag ggcgcatcgc
3696961 gggtggcctc atagatcaac agcagcgtga gctcgcgcag cgctgcccgg aagccggcgt
3697021 tgtcggtgcg ttcgtcacgc agcgtggtca gtcgggccgc ggccagtggg tggtcaacga
3697081 catggacctg cacggcgttg aaccctatat aacaatcgtg gctcggtccc ctaaaagggg
3697141 gctgatacgg gtgcgtccat ccgcgcgacc ggtcaacccc gtccatatac tcccggcatg
3697201 ctccgcggaa tccaggctct cagccggccc ctgaccaggg tataccgtgc cttggcggtg
3697261 atcggtgtcc tggcagcatc gttgctggcc tcatgggtcg gcgctgtccc acaagtgggt
3697321 ctggcagcga gtgccctgcc gaccttcgcg cacgtggtca tcgtggtgga ggagaaccgc
3697381 tcgcaggccg ccatcatcgg taacaagtcg gctcccttca tcaattcgct ggccgccaac
3697441 ggcgcgatga tggcccaggc gttcgccgaa acacacccga gcgaaccgaa ctacctggca
3697501 ctgttcgctg gcaacacatt cgggttgacg aagaacacct gccccgtcaa cggcggcgcg
3697561 ctgcccaacc tgggttctga gttgctcagc gccggttaca cattcatggg gttcgccgaa
3697621 gacttgcctg cggtcggctc cacggtgtgc agtgcgggca aatacgcacg caaacacgtg
3697681 ccgtgggtca acttcagtaa cgtgccgacg acactgtcgg tgccgttttc ggcatttccg
3697741 aagccgcaga attaccccgg cctgccgacg gtgtcgtttg tcatccctaa cgccgacaac
3697801 gacatgcacg acggctcgat cgcccaaggc gacgcctggc tgaaccgcca cctgtcggca
3697861 tatgccaact gggccaagac aaacaacagc ctgctcgttg tgacctggga cgaagacgac
3697921 ggcagcagcc gcaatcagat cccgacggtg ttctacggcg cgcacgtgcg gcccggaact
3697981 tacaacgaga ccatcagcca ctacaacgtg ctgtccacat tggagcagat ctacggactg
3698041 cccaagacgg gttatgcgac caatgctccg ccaataaccg atatttgggg cgactagccg
3698101 ccgtcgctat tctgtgccgc atggttgctg acctcgtacc catccgcttg agcctgtccg
3698161 ctggtgaccg ctacacgctg tgggctcctc gctggcggga tgccggcgac gagtgggagg
3698221 cgttcctggg caaagacgac gacctgtatg gcttcgagag cgtctctgac ctggtcgcgt
3698281 tcgtgcgcac cgacaccgag aacgacctgg tcgaccaccc ggcatggcaa gacctgaccg
3698341 gagcccacgc gcacaacctc aatccggccg aagacaatca gttcgacctg gtcgtcgtcg
3698401 aggaactgct ggctgagaag ccgacggcgg agtcagtggc cgcgctggcc gcctcattgg
3698461 cgatcgtatc cgccatcgga tcggtgtgcg aactggcggc agtgtcgaag ttcttcaacg
3698521 gcaatcccat cctgggcacg gtttccggcg ggctcgaaca cttcaccgga aaagccggca
3698581 ataaacgctg gaattcgatt gccgaggtca tcggacgcag ctgggacgac gtgctcgcgg
3698641 ccatcgacga gatcatcagc acccccgagg tcgacgctga gctgtcggaa aaggtcgccg
3698701 aggagttggc ggaggagccc gagggcgccg aggaagtggc ggcggaggtg gaggccacgc
3698761 aggacacgca ggaggcggcc gagtccgacg acgaggaagc cgacgcaccc ggtgacagtg
3698821 tcgtactggg cggcgatcgg gacttctggt tgcaggtggg catcgacccg atccagatca
3698881 tgacgggcac cgccaccttc tacacgcttc gctgttacct ggatgatcga ccgatcttcc
3698941 tgggccgcaa tggtcggatc agtgtgtttg gctccgagcg ggcattggcc cgctatcttg
3699001 ccgatgagca cgaccacgac ttgtcggacc tgagcaccta cgacgacatc cgcacggccg
3699061 ccaccgacgg ctcgctggcg gttgccgtta ccgacgacaa cgtctatgtg ctcagtgggc
3699121 tggtcgacga ttttgccgac gggccggacg cggtggaccg tgagcagctc gacctggccg
3699181 tcgagctgct ccgcgatatc ggcgactact ccgaggacag cgcagtcgac aaggcactcg
3699241 agacaacccg cccgctgggc cagctggtgg cctatgtgtt ggacccccac tcggtcggca
3699301 aacccacggc cccgtatgcg gcggctgtcc gtgaatggga gaaattggaa aggttcgtgg
3699361 agtcgcggct caggcgcgaa taggcaccgt cagccggcga aggctagccg ccgcggcgct
3699421 tgccgatgtc cagggcacac gcggcgagga tcgcatccca gtcttcgatg ttgaaatggc
3699481 ccttgccgtg cgcccagtgc aaatcaacgt gcggaatcgc gcgctgcagg tattcgccca
3699541 tggcgcgtgg cacgaaggag tcacgatcac ccagccagat atgggtaggc acggccacct
3699601 cggcgaggtc gaaaccccac ggccgaaatt gcagaaatga ttcataggct gcgccgcggc
3699661 tgccctgtcg gaacgcttcg agctggatgg cgcgcaggtg gcggccgaag cgttcgtcgc
3699721 tcagcaggtg cttgtcggcc gcggggaccg cagccgccaa caacgtagaa aacagcccgg
3699781 gcgtgtattt cgcgcaccag ccgagcgggg caaacaacgc accgaatagc cgcggcccgc
3699841 ttcgcgccaa ccgcgcgtag caccgatcgg ccgcgttgag gctgcgcatg atatccggcg
3699901 tcgccagtgg accccatggt ccgagcgcgc cgacgaacgc tagtcgggtc cgcgggatga
3699961 cggcaccgca ggcgaatagg tgcggtcccg cgcccgaatg cccgaccacc ccgaactcct
3700021 ccagctcgaa cgcgtcagcc agggcacaca cgtccgcggg ccaatcgcga aaattgcgtc
3700081 ccgcttgaaa ggtggagcgc ccgtacccgg gccgatcaat cgctatcagt cggaagccgg
3700141 tgcgccgcgc ggcaccatcg gcgaaggccc cctcgagccg cgaacttggc gtgccgtgga
3700201 agtagaacgc tgggtagccg gtgctatcac cccattccag gtaggcaagc gcccgcccgt
3700261 cgggcagcat gagcacatcc gcctcgtcgg tgcgaatgcg ctcgggcagc gatggcggtg
3700321 gcccggtcaa gagcacacca gcgatggtat gccgatcaga gtcgattcag cgcgcgtgcc
3700381 atgcacgagt cctcgaggaa ccgatagcgc ctaggctggg actgccgcaa ccacagccga
3700441 tccagcgccg aacgcacgat ccggcgaacg ggtgtgcggg taacagcctt gtcgatgtcg
3700501 atggtggagg cgctgtcgcc gttcatgaca ggttcccttc aagcgtcctg caagcggttg
3700561 ccaaagccgt cgcctatttt ctgtcatcgg acggcgcgat ccatcggcac gggagcgtaa
3700621 atctgccccg ccgggggtcg tagcttgccg ggggcacgcc cgggtttata cgcgtattcg
3700681 ctgatgcggc ccggtcaacg agcgctatgc gccgccaccg gcagccgggg gcggcggcgc
3700741 agcaccggga tcgtcaagca cgggaccttc gaggatgggt ccggggtagt cgcggctgtg
3700801 gtcggggccg tcgctgtcgc ggtggaagtc gtcatggcag gtgtagggat cccagttggg
3700861 cccccatgcg gggtcgaaag gctgccccgg gcaccagtag tagtcgggca ccggcgcggt
3700921 ttgggctgcg gactgcgcgc cgaccccgag acccgccaca cccgtggcca ggatgcacgc
3700981 cgccagcatg agcgtgcggc acgcgaaccg gtacatgcga tgacggtacg aaagcgatct
3701041 ggcaagcaac tggacgctag gtgcgatata ccagagaact tgctgattac tcgctgtgac
3701101 ccatgagcgc cgcgaaccgc ggcttgatca cttcgtcgat tatcgccagc cgctggtcga
3701161 acggaatgaa cgcggatttc atcgcattga cggtgaagcg cgccaggtcg ctccagccat
3701221 aaccgaaagc ctctaccaaa cgatgcattt cgaggctcat cgaggtgtcg ctcatcagcc
3701281 ggttgtcggt attgacggtc acccggaacc gggcccgagc cagtaggtcg aacggatgct
3701341 cggcgatgct tgcgaccgcg ccggtctgca cgttggagct ggggcacagc tccagcggaa
3701401 ttcgcttgtc ccgcaggata gctgccagcc gacccaactg gaaaccgccg tcggcatcca
3701461 cgtcgatgtc gtcgacgatc cgcaccccgt gacccagccg gtcggcaccg cagaaggcga
3701521 tcgcctcgtg gatggacggc aacccgaacg cctcaccggc atgaatcgtg aagcgcgcgt
3701581 tgtgatcacg catgtactcg aatgcatcca agtgccgggt tggcgggtgg ccggcctccg
3701641 cgccggcgat gtcgaatccg acaactccct tgtcccggaa ccggatcgcc aactctgcga
3701701 tctcccggga cattgcggcg tgccgcatcg cggtgaccag acagcggacg gtgatgggtt
3701761 gaccatcggc ggcacacgcc ttctcgccgg cggcgaagcc cgtcagaacg gtgtcgacga
3701821 cgtcgtcgaa cgacagcccg cagctgatgt gcagctccgg cgcgaaccgc acctcggcat
3701881 agaccaccga atcggcggcc aggtcttgcg cgcattcgaa ggcgacccga tacaaggcct
3701941 cgggagtctg catcaccgcc accgtgtgcg aaaacggttc caggtagcgc tccagcgagc
3702001 cgctgtgcga ctgggtgcga aaccaacttg ccagcgcgtc gacgtcagtt gccggcaggt
3702061 cgtcgtatcc gacctgcccg gcaatgtcca gcacggtggc cggccgcagc ccgccgtcga
3702121 ggtgatcgtg cagcaacgcc ttgggggcta gcctgatcgt ctgcagggtc ggcgcagcgg
3702181 tcatcagacg atccgatcga cgattagcgg ccgcacctgc ggcggactgt cccggatact
3702241 ccaaccgccg gccagctcgg ctcgcgccgc accaaagcgc tcgggagcat tcgtgtagag
3702301 ggtgaacaac ggctcaccga ccacaaccgg ctcccccggg cggcgatgaa tccgcacccc
3702361 cgcaccgtgc tgtacgcgtg cgcccgggcg ggacctgccc gcaccgagtc gccatgccgc
3702421 taaccccact gccatcgcat cgatgtcgcc cattgtgccg ctcgcgcccg ccgtgacggt
3702481 ttccgaatgc gaaccgatcg gcaacggttt cgacaagtca cctccctgcg cggcaaccaa
3702541 ccggcgaaac cggtccattg cggtgccgtc ccgcagcgtc tgggccgggt cccggccgtg
3702601 gatcccggca agctcgagca tctcgccggc cagccgcaac gtcagctcca ccacgtcggg
3702661 cggtccgccg ccggccagca cctccagcgc ctcggccacc tcgagcgcat tgccgacggt
3702721 tcgacccagc gggcagttca tctccgtcag cagggcacgg gtgggcacgc catgcgccgc
3702781 gcccagttcg accatggtgt gcgcaagttc gcgcgcctgc actggcgacc tcatgaaggc
3702841 cccggaacca accttgacgt cgagcaccag tgcacccgca ccctcagcca gcttcttgct
3702901 cataatcgaa ctggcgatca acggcagcga ttcgacggtg ccggtaatgt cgcgcagcgc
3702961 atacagcttg gcatcggctg gcgccagctg gccggcggcg aagatcgcgg cgccgacgtc
3703021 gcaaagctgc tcgcgcaccc gctggttgga cagattcgcg gtgaacccgg tgatggattc
3703081 cagcttgtcc agggtgccgc cggtgtggcc gagtccgcgg cccgacgcct ggggcactgc
3703141 gccaccgcag gcggcgacga cgggcaccaa tggcagcgtg attttgtcac ctaccccgcc
3703201 ggtggaatgc ttgtccacgg tcgctagtgg cagatcggtg aaatccagcc gggcacccga
3703261 ggccagcatg gccgccgtcc atctggcgat ctcgccgcgg tccatgcccc gccaaacgat
3703321 cgccatcagc agcgccgaca tctgttcgtc ggcgacccgg ccgtcggtat aggccttgac
3703381 gacccagtcg atggcggcgt cggacaaccg gccgccgtca cgtttggtgc ggatgacggt
3703441 cggggcgtcg aatgcgaagt cggtcaccgg cgttcccggg ggaggtcgtc gaggccgaag
3703501 gcgtcgggca gcaggtcgcc gagccggcgg ggtcgcaccg gatggtcgat cagtagctcg
3703561 gaacccccgt gttcgagcag cacctgacgg catcgcccgc acggcatcag cacggatcca
3703621 tggccgtcga cgcaggccag cgcgagcagc cggccgccgc cggtcgaatg cagggcgcac
3703681 accaccgcac attcggcgca caaagtcaag ccatacgaga cgttttccac gttgcatccg
3703741 gtcaccacgc gaccatcgtc gaccagtgcg gccgcaccca ccgcaaaccg cgaatacggc
3703801 acataggctc cggctgctgc ctgggttgca ttgccccgca gcatattcca atcgacatca
3703861 ggcattcggc aaccccgctc gtcgatgggc cgactaagaa aagccagcct aaccccggat
3703921 ccacacacga tcccgatcgg actgttcgac accgcgggca acctggccaa gttaagctcg
3703981 attgcccggc tctagctgtt cgatagtgct tttaaggggt ttgccagcgg tgaatacaac
3704041 ggcgacaacc gtctcgcgcg ggcggcggcc acctcggacc ctgtatcggg gagatcccgg
3704101 tatgtggtcg tgggtatgcc atcgcatcag cggcgcgacg attttcttct tcctgtttgt
3704161 ccatgtcctg gacgccgcca tgctgcgggt gagcccgcag acctacaacg cggtgctggc
3704221 gacctacaag accccgatcg tcggcctgat ggagtacggc ctagtcgccg cggtcctttt
3704281 tcacgcactg aacgggattc gggtcatctt gatcgatttc tggtcggaag gcccgcgcta
3704341 tcagcggctg atgttgtgga tcatcggcag cgtcttcctc ttgctgatgg ttccggcagg
3704401 cgtggtggtg ggcatccaca tgtgggagca cttccgatga gcgccccggt cagacagcgc
3704461 agccatgacc gtccagccag cctggacaac ccacgatcac cacggcggcg tgccggcatg
3704521 cccaacttcg agaaattcgc ctggctgttc atgcggtttt ccggtgttgt gttggtgttc
3704581 ctggcgatcg ggcacgtgtt catcatgctg atgtgggaca acggcgtgta tcgcctggac
3704641 ttcaacttcg ttgcccaacg ctgggcgtcg ccgttctggc agacctggga tctgctgttg
3704701 ttgtggctgg cgcagctgca cggcggcaac ggtctgcgca ccatcattga cgactacagc
3704761 cgcaaagaca ccacccgatt ctggctgaac tcgttgctgg tgttgtccat gctgttcacc
3704821 ctgatgctgg gaacctacgt gatagtgaca ttcgacccga acatctcctg aaaggcccgg
3704881 aaggagcaca tgatcacgcc acctctcccc cgcaagcggg cggtaccccc acctcatcgc
3704941 tgcggccccc tcgtcgcttc gcggctgggg gtgcccccac tgcatcgtcg gcggcggcgt
3705001 tgatctgcca acaccgatac gacgtggtga tcgtcggcgc gggcggtgcc gggatgcgcg
3705061 ccgcggtcga ggcgggtccg cgggtgcgta ccgcggtgct gaccaagctg tatcccaccc
3705121 gcagccacac cggcgcggcc cagggcggca tgtgcgccgc gctggccaac gtcgaggacg
3705181 acaactggga gtggcacacg ttcgacaccg tcaagggcgg cgactatctc gccgaccagg
3705241 acgccgtgga gatcatgtgc aaggaagcca tcgacgcggt gctcgacctg gagaagatgg
3705301 ggatgccgtt caaccgcacc cccgagggcc gcatcgacca gcgccgcttc ggcgggcaca
3705361 cccgcgacca cggcaaggcc ccggtgcgcc gggcctgcta cgcggccgat cgcaccggcc
3705421 acatgattct gcagacgctg tatcagaact gcgtcaagca cgacgtcgag ttcttcaacg
3705481 agttttacgc gctggatttg gctttgactc aaacgccgtc gggcccggtg gccaccgggg
3705541 tgatcgccta cgagctagcg accggtgaca tccatgtctt tcacgccaag gccgtcgtga
3705601 tcgcgaccgg cggctcgggc cgcatgtata agaccacgtc caacgcacac accctgaccg
3705661 gcgacggcat cggcatcgtg ttccgcaagg gacttccctt ggaggacatg gagtttcacc
3705721 agtttcaccc taccggcctg gccggtctgg gcatcttaat ctccgaagcg gtgcgcggcg
3705781 aaggcggccg gctgctcaac ggggaaggtg agcgtttcat ggagcgctac gccccgacga
3705841 tcgtcgacct agcgccccgc gacatcgtcg cccgctcgat ggtgctggaa gtgctggagg
3705901 gacgcggcgc cggaccgctc aaggactacg tctacatcga cgtccgccac ctgggcgagg
3705961 aagtgctcga ggccaagctg cccgacatca ccgagttcgc ccgcacctac ctgggcgtgg
3706021 atccggtcac cgagctggtg ccggtctacc cgacgtgcca ctacctgatg ggcggcatcc
3706081 cgaccacagt caccgggcag gtgctgcggg acaacaccag cgttgtcccg ggcctgtatg
3706141 cggccggcga gtgcgcgtgc gtgtcggtgc atggcgccaa ccggctgggc accaactcgc
3706201 tgttggatat caacgtcttc ggtcgtcggg ccggcatcgc cgccgccagt tatgcgcagg
3706261 gtcacgactt tgtcgacatg ccgcccaacc cggaggccat ggtggtgggc tgggtcagcg
3706321 acatcctgtc cgaacacgga aacgagcggg tcgccgacat tcgcggggcg ctgcagcagt
3706381 cgatggacaa caacgccgcg gtgttccgca ccgaggagac cctgaagcag gcgctcaccg
3706441 acatccacgc gctcaaggag cgctactccc gaatcacggt gcacgacaag gggaaacgct
3706501 tcaacaccga cctgctggaa gccatcgagc tgggattttt actggagctg gccgaggtca
3706561 cggtggtcgg cgctttgaat cgcaaggagt cccgcggcgg tcacgcccgc gaggactatc
3706621 ccaaccgcga cgacgtcaac tacatgcgac acaccatggc ctacaaggaa attggggccg
3706681 ataaggaggg ccccgagctg cgcagcgatg tccgccttga tttcaaaccc gtcgtgcaga
3706741 cccgttacga acccaaggaa cggaagtact aatgagcgtc gagccggacg tcgaaacttt
3706801 ggatccgccc ctaccgccgg taccggacgg cgcggtgatg gtgaccgtca agatcgcccg
3706861 gttcaacccc gacgaccccg acgcgttcgc ggccaccggc ggctggcaga gcttccgggt
3706921 gccctgtttg cccagcgatc ggctgctcaa cctgctcatc tacatcaagg gctacctcga
3706981 cggcacgctc accttccggc gatcctgcgc ccatggggtg tgcggctctg atgccatgcg
3707041 catcaacggg gtgaaccggc tggcctgcaa ggtgctgatg cgtgacctgc tgccgaagaa
3707101 gaagggcaaa tcgttgaccg tcacggtcga gccgatccgc gggctgccgg tggaaaagga
3707161 cctggtggtc gacatggagc cgttcttcga cgcctaccgg gcgatcaaac cgtacctgat
3707221 caccagcggc aacccgccca cccgcgaacg gatccagagc ccgaccgacc gcgcccgcta
3707281 cgacgacacc accaagtgca tcctgtgcgc gtgctgcacc accagctgcc cggtgttctg
3707341 gcacgagggc agctacttcg gcccggcggc gatcgtcaac gcgcaccgct tcatcttcga
3707401 cagccgcgac gaggccgccg ccgagcgcct cgacatcctc aacgaggtcg acggggtgtg
3707461 gcgctgccgc accacgttca actgcaccga atcctgccca cggggcattg aggtgaccaa
3707521 ggcgatccag gaggtcaagc gcgcgctgat gttcacccgc tgagggcttg cgcgagcaga
3707581 cgcaaaatcg cccgaaaacc agtggttttg ggcgattttg cgtctgctcg cgcagccggg
3707641 tctacagcgt tgccaggtgc tgtttggttg cgccaggaac cgcagtcaac gcaatcgact
3707701 gatcgaaggt gacaaatcgg ccatcatgag cgaccgcgag ggccagcaag tacgcgtcgg
3707761 tgacctgttt ggggctgtgc aggcgggaac gatcgatgac ctttgagtcg agaatgctga
3707821 cggtgcagga ccagaactcg tgatagcgcg tgtgcgtcgc acgagccaac aagtcgatgg
3707881 catgggctac cgagattggg ctgggatagc gcggttggct gatgacgcgg acgaacccgt
3707941 tttgggtgat cgcacaggaa gcccatcccc gctcgatctg cccggtgatc cacgctcggg
3708001 cgcgctcgtg gtcgacgtga tcgcggtcca acagcgccag tagcacgttg acgtccaaca
3708061 gcgctcgcat cgatcacacg gcctcctcgt cacgaagccg atcgatcagc gcgttcgata
3708121 ccgctccacc gcgatgaggc aggggttcga agccatgaaa ggcgtcctcc tggctcgccg
3708181 caggctgggg attctggttg gttaacgctt gccgggccag atccgacagg atttcacccg
3708241 cggtgcgctt ctccctgcgt gcccgttcct tcacggccag caatacatcg tcgtcgatgg
3708301 acaacgtggt gcgcatgcat cagatgctat cgcaccaatc tgggcgcaac gcgtctacag
3708361 gatggccagc gctcgcggca ttgagaatct ccttcgtggg tgcactccca cgcgaggtag
3708421 gggccgacga ccaccatcta tgcccctggc aacggtgagc gccgcgcgat catgatccgc
3708481 gacggcgccg aatcgcagtt accctgcccc tcgtgtacaa cggtgaagtc ggcaggaagc
3708541 agacacgctg gctctcccgg cttgacacgt cgcttcgcgc tggctgtgcc cgcctcggcg
3708601 ccactgagag ccagcgactc ccatgccaat acgccgcctg gcatcaccgc ctcacaggcg
3708661 cggtgaaata tcgccgcatc ccaaaagagc ctgctgagca ccagcgcgaa acgcgtctcg
3708721 ccgggttccc agcagcccaa gtcggcctgc acgaggttga gccgatcggc cacgcctcga
3708781 cgcacggcct cgctgtccag ctgcagcagc gcgacatcgg acacatcgat tgcggtgacc
3708841 tggcggccgt gggcggccaa cgccagtgcg gtacccgatc gaccgctggc taactccaga
3708901 acgggaccgt ccggaacgcc tgctctgagg acatcggcga gccaaggcac cggggcaaac
3708961 ggcgcgtgcg ccgaacccgc gcgttcgtat cgcgcgttcc agtcgacgcg gttggggtgc
3709021 tcccgcagcg ccggatccgt ctgcacgctc atggccgatt ggccacccac tcaacaccgt
3709081 cgagtgcgaa ctccttcttc catatcggca catcctgttt gagccgctcg atgcacatgc
3709141 gagcggcgtc gaacgcggcc gcgcggtgag gagccgaagc accgatgaca accgccgcat
3709201 caccgatgcg caattcaccg gtccggtgtg ccacggcaac tcgcacaccg tcggcctgtc
3709261 gttcacactc ttcgatgatg tccatcagcg tgcggtgcac catggccgga taggcctcgt
3709321 agtacaactt ggtcacttcg tggccgttgt tgttgttacg cacggtaccc acgaagatga
3709381 cggcgccgcc ctgggaaggt ccagatatcg cgttgagcac ttcatcgacg ctcagcggct
3709441 catcggtgag ccggcagtag acatcggagc ccccggcaac ctgcggtatg aacgccaccg
3709501 tgtcgccatc gtcgagaatc gttgatgctg gcgctatgga ttcgttaacg gccatccgca
3709561 ctcgcttgcg aaaatcagca agtggcggat agtcgatttg caattggtcg actaagccgt
3709621 cgacggtggt gccgctttcg agtgagatct tctcgtgagc gaccttgcac gcttcgcgaa
3709681 ccgcgccaaa gtagagcaca ttgacagtaa tcattcaaca tccatcctcg gtggagccac
3709741 catcgctggg tttgacgtcc gcgtcgtgcc gccggtaatg acccgatcgg ccaccgcttt
3709801 tttcgtccaa tctgatatcc gtgatcgtca tggcacggtc gactgctttg cacatgtcgt
3709861 aaaccgtgag cgctgtcacc gtaacggcgg tcaacgcctc catctccaca cccgtacgtg
3709921 ccaccgtggt caccgtcgcc gcaatcgaga gccggtccgc gccctgcggc tcgagcgtga
3709981 cggtgaccgc ctcgatcccc agcgggtgac acagcgggat aagctcaccg gtccgtttgg
3710041 ccgccataat gccggctatc cgtgcggtcg ctatgacatc gccctttgcc gcggtgccgt
3710101 gacagatcat gtccagggtc gacggtttca tcaggacggc cccggatgcc cgcgctcgcc
3710161 gcaaggtcac cgccttcgcc gacacatcga ccattcgggc ggcgccttgt tcatcaaggt
3710221 gggtaagcac cccatcgtgg tcgttcaccg tgccacctgc tggctgcatt gctcatcgtg
3710281 cactgcgctg aaagcctcgg cgaggtcgaa gtcgacgcga gtcaaacagt gcatctggcg
3710341 cgtccaacaa gtcaaccgca ccgaccgctt gttatggaca ctgaaccgcc ccggcatgtc
3710401 cggagactcc agttcttgga aaggatgggg tcatgtcagg tggttcatcg aggaggtacc
3710461 cgccggagct gcgtgagcgg gcggtgcgga tggtcgcaga gatccgcggt cagcacgatt
3710521 cggagtgggc agcgatcagt gaggtcgccc gtctacttgg tgttggctgc gcggagacgg
3710581 tgcgtaagtg ggtgcgccag gcgcaggtcg atgccggcgc acggcccggg accacgaccg
3710641 aagaatccgc tgagctgaag cgcttgcggc gggacaacgc cgaattgcga agggcgaacg
3710701 cgattttaaa gaccgcgtcg gctttcttcg cggccgagct cgaccggcca gcacgctaat
3710761 tacccggttc atcgccgatc atcagggcca ccgcgagggc cccgatggtt tgcggtgggg
3710821 tgtcgagtcg atctgcacac agctgaccga gctgggtgtg ccgatcgccc catcgaccta
3710881 ctacgaccac atcaaccggg agcccagccg ccgcgagctg cgcgatggcg aactcaagga
3710941 gcacatcagc cgcgtccacg ccgccaacta cggtgtttac ggtgcccgca aagtgtggct
3711001 aaccctgaac cgtgagggca tcgaggtggc cagatgcacc gtcgaacggc tgatgaccaa
3711061 actcggcctg tccgggacca cccgcggcaa agcccgcagg accacgatcg ctgatccggc
3711121 cacagcccgt cccgccgatc tcgtccagcg ccgcttcgga ccaccagcac ctaaccggct
3711181 gtgggtagca gacctcacct atgtgtcgac ctgggcaggg ttcgcctacg tggcctttgt
3711241 caccgacgcc tacgctcgca ggatcctggg ctggcgggtc gcttccacga tggccacctc
3711301 catggtcctc gacgcgatcg agcaagccat ctggacccgc caacaagaag gcgtactcga
3711361 cctgaaagac gttatccacc atacggatag gggatctcag tacacatcga tccggttcag
3711421 cgagcggctc gccgaggcag gcatccaacc gtcggtcgga gcggtcggaa gctcctatga
3711481 caatgcacta gccgagacga tcaacggcct atacaagacc gagctgatca aacccggcaa
3711541 gccctggcgg tccatcgagg atgtcgagtt ggccaccgcg cgctgggtcg actggttcaa
3711601 ccatcgccgc ctctaccagt actgcggcga cgtcccgccg gtcgaactcg aggctgccta
3711661 ctacgctcaa cgccagagac cagccgccgg ctgaggtctc agatcagaga gtctccggac
3711721 tcaccggggc ggttcagagg caaccaccat ggttgttgtt ggaaccgatg cgcacaagta
3711781 cagccacacc tttgtggcca ccgacgaagt gggtcgccaa ctcggtgaga agaccgtcaa
3711841 ggccaccacg gccgggcacg ccacagccat catgtgggcc cgtgaacagt tcggcctcga
3711901 gctgatctgg ggcatcgagg actgccgcaa catgtcggcg cgtctggagc gtgacctact
3711961 ggcggccggc cagcaggtgg tgcgggtacc caccaagctg atggcccaga cccgcaagtc
3712021 ggcgcgcagt cggggcaagt cggatccgat cgatgcgctg gcggtggcgc gggcggtgct
3712081 gcgtgaaacc gacctacccc tggccaccca cgacgagacg tcgcgggagt tgaagttgtt
3712141 gactgaccgt cgagatgtcc ttgtggccca acgcacgtcg gcgatcaacc ggttgcgctg
3712201 gctcgtccat gaactcgatc ccgagcgggc accggcagca cgctcgctcg atgccgccaa
3712261 gcaccagcag gccctgcgga cctggctgga cacccagcca ggattggtcg ccgaactcgc
3712321 gcgcgccgag ctgaccgaca tcatccggct caccggcgag atcaacaccc tagcccagcg
3712381 catcagcgcc cgagtccacc aggtcgcccc cgcactgctg gaaatccctg gctgcgcgga
3712441 gctgactgca gccaaaatcg tcggcgaagc cgccggagtg acccggttca aaagcgaagc
3712501 cgccttcgcc tgccatgccg cagtggctcc catcccggtg tggtcgggca acaccgccgg
3712561 ccagatgcgg ctcagccgct cgggcaaccg ccagctcaac gccgccctac accgcatcgc
3712621 actgacccaa atccggatga ccgacagccg gggccaggcc tactaccaaa ggctgcaaga
3712681 cgccgggaaa accaaacgcg cagcactacg ctgcctcaaa cgccgcctag cccgcaccgt
3712741 cttccaggcc ctgcgcaccg tccaccagcc cagctccgaa cacacccaac ccgcggccgc
3712801 ttgccatagg agctattgct cgtcacacct cggcgagcca cctcgtctaa cggatatgac
3712861 acagaaaacc cgcatccagc ccctacctcc caagcgagcc ggcctgttga tccgcgcact
3712921 gtatcggatc gccaagcggc gcttcggcga agttcccgag ccgttcacgg tcaccgcaca
3712981 tcatcggcgg ctgctgatcg ccaatgtggt gcacgaagcc ctgctgcagc gagcgtcgcg
3713041 gaagctaccg cccagcgtcc gtgagctggc ggtgttttgg accgcccgca gcatcggctg
3713101 ctcgtggtgc gtggacttcg gagccatgct gcagcgcctg gacgggctgg acgtggacag
3713161 gctcacggac atcgacaatt acgccacctc atcgaaattc agcgacgacg aacgcgccgc
3713221 catcgcctac gccgaggcga tgaccgcaga cccgcattcg gtgaccgacg agcaggtggc
3713281 cgacctgcgg gcccgcttcg gcgaggccgg cgtgatcgag ctgacttacc agatcggcgt
3713341 ggagaacatg cgagcccgga tgaattcggc gctgggcatc accgagcaag gcttcaattc
3713401 cggtgatgcc tgccgcgtcc cgtgggctgc gcccgacgtt ccttcagcgg agagccggtg
3713461 aacttgtcgg gattggcgat atcccacagc gcgcacacct ttccgtcgcg cacggttatc
3713521 gcggtgatcc gcggcgccat cgcccgatac ccgtcgaccc cgggtaagcc cgccgtgtag
3713581 gcgccgagct ctccgttgac cagcgccagc tgattcgcgc cgaagagccc cgggccgtaa
3713641 cgctggacca gcccgagtat gaaccggacc accttgtcgg atccgcggac ggcccgtacc
3713701 gctgtgggcg ccttgccatt cgaatcgccg gtaaacgtca cgtcgggatg cagcagcgac
3713761 accaccgtgt ccaggtcacc agcggccatg gcggccatca gccggccgac cacctcgttg
3713821 tgggccggat ccggatcccc cgatatcagg gcgggctgcg ccgtgacggc cttgcgggcc
3713881 cgcgacgcca gctggcgcgc ggcggcctcg ctggttccca gcacctcggc cacttcggca
3713941 aacggcacgg cgaacccgtc gtgcagcacg aacgcgaccc gctgatcggg gcgcagccgc
3714001 tccagcacca ccatggccgc gaacctggcg tcctcggcgg ccaccacggc ggccaacgga
3714061 tcggtcgcgt ccaagccggt gaccaccggt tcgggcagcc aggtgccggt gtaggtctcc
3714121 cgccggtgcg ccgccgacct caacttgtcc agacccagcc ggctcaccac ggtggtcagc
3714181 caggcccgcg ggtcggcgat cacggtgtcc ggtgagtccc agcgcagcca ggcctcctgc
3714241 acgatgtcct cagcatcggc gaccgtgccg gtcagcctgt aggcgaccga catgagatgc
3714301 tgtcgcagtg cctcgaattc ggaaacctcc atcgaggtca ttgcccgagc ctagcgctgc
3714361 gctcgccaac acgacgacac gaaacctttg gttgcacttc gcccggcacg gtgccggcat
3714421 ccaacacccg gtcatcgtcc gcggcgacgg cgtcaccatc ttcgacgacc gcggcaagag
3714481 ctatctggac gccttgtccg ggctgttcgt ggtgcaggtc ggttacggcc gggccgaact
3714541 cgccgaggcg gccgcgcggc aagccggcac gctggggtat ttcccgctct gggggtatgc
3714601 caccccgccg gcgatcgagc tcgccgagcg cctggcccgc tacgcgcccg gggacctaaa
3714661 ccgggtgttt ttcaccagcg gcggcaccga ggccgtcgaa accgcctgga aggtggccaa
3714721 gcagtacttc aagctcaccg gcaaaccggg caaacaaaag gtcatttcac gctcgatcgc
3714781 ctaccacggc accacccagg gcgcgctggc gatcaccggc ctgccattgt tcaaggcgcc
3714841 attcgaaccg ctgacgccgg gcggcttccg ggtgcccaac accaatttct accgagcacc
3714901 gttgcacacc gacctcaaag agttcgggcg atgggctgct gaccggatcg ccgaggccat
3714961 cgagttcgaa ggccccgaca ccgtggccgc ggtgtttttg gagccggtgc agaacgcggg
3715021 cggctgcatc ccggcgccgc cgggttattt cgaacgggtc cgcgagatct gtgaccgcta
3715081 cgacgtgctg ctggtctccg acgaggtgat ctgtgcgttc ggccggatcg ggtcgatgtt
3715141 cgcctgtgaa gacctcggct acgtgcccga catgatcacc tgcgccaagg gcctgacgtc
3715201 gggctactcg ccgctgggcg cgatgatcgc cagcgaccgg ttgttcgaac cgttcaacga
3715261 cggcgagacg atgttcgcac acggctacac gtttggcggt catccggtgt cggcggccgt
3715321 cggcctggcc aacctcgaca tcttcgagcg cgagggtctc agcgatcacg tcaagcggaa
3715381 ttcccccgcg ctgcgggcca ccctggagaa actgtacgac ctgcccatcg tcggcgacat
3715441 ccgcggcgag gggtatttct tcggcatcga actggtcaaa gaccaggcga ccaagcaaac
3715501 cttcaccgat gacgaacgcg cacgactgct aggccaggta tccgcggcgc tctttgaggc
3715561 cgggctgtac tgccgcaccg acgaccgcgg ggaccccgtc gtccaggtgg ctcccccgct
3715621 gattagcgga cagcccgagt tcgacaccat cgaaaccatc ctgcgcagcg tgctcaccga
3715681 caccggacgc aaatatcttc atctgtaact ttcgtcccgc cagtcacagc gcggctcctc
3715741 gcggtcgggc cgccgatcac ctactctgca cagacgatgg ccttcttacg ttcggtatcg
3715801 tgcctggcag cagccgtgtt tgcggtaggc accggaattg gtctacctac cgcggccggc
3715861 gaacccaatg ccgcaccggc ggcgtgcccg tacaaggtgt ccaccccacc cgccgtggac
3715921 tcgtcggagg ttcccgcggc cggtgaaccc ccactgccgc tggtggtacc ccccaccccg
3715981 gtcggcggca acgcgctggg cggctgcggc atcatcaccg cccctggcag cgcgccagcg
3716041 cccggcgacg tctcagccga ggcctggctg gtggcggacc tggacagcgg cgcggtgatc
3716101 gccgcccggg atccgcacgg ccggcaccgc ccggccagcg tcatcaaggt gctggtggcg
3716161 atggcgtcca tcaacacgct caccctcaac aagtcggtcg ccggaaccgc cgacgacgcg
3716221 gcggtcgagg gcaccaaagt cggggtgaac accggtggca cctacaccgt caaccagctg
3716281 ctgcacgggc tgctgatgca ctccggcaac gacgctgcgt acgcgctggc caggcagctc
3716341 ggcggcatgc cggccgcgct ggagaaaatc aatctgctgg ccgccaagct gggcggccgg
3716401 gacacccgag tggccacgcc gtccggactg gacgggcccg gcatgagcac gtcggcctat
3716461 gacatcggcc tgttctaccg gtacgcgtgg cagaacccgg tcttcgccga catcgtcgcg
3716521 acccgcacct tcgacttccc ggggcacggc gaccatccag gctacgagtt ggagaacgac
3716581 aaccagctgc tctacaacta tccgggcgcg ctcggcggca agaccggcta taccgacgac
3716641 gcggggcaga ccttcgtggg cgcggccaac cgcgacggcc ggcggctgat gacggtgctg
3716701 ctgcacggga cccggcagcc gatcccgccg tgggagcagg cggcgcacct gctcgactac
3716761 gggttcaaca ccccggcagg cacccagatc gggacactga tcgaacccga cccgtcgctg
3716821 atgtccaccg accgcaatcc cgccgaccgg caacgagtcg acccccaggc cgcggcgcgg
3716881 atatcggccg ccgacgccct tccggtgcgg gttggcgtgg ccgtcatcgg cgccctgatc
3716941 gtgttcgggt tgatcatggt cgcgcgggcg atgaaccgcc ggccgcagca ctagctgctt
3717001 accccgatac cttcggcgtc gtttgcgggc gggcatccta gccggccttg gtcggcaccg
3717061 aaatcggggc ttgaccagcg gttgaccgcg tgacgacgct gtggcagcct catcgaaatg
3717121 actacagccc tataccagga cgcggggttc acgcccgccg gggcgcccga cgaccccgac
3717181 cgcgtggtgg acgtgctgag cgccccggta ccggtcaact gaccagatcg gggcgccggg
3717241 cgctcctcgt cgggctcacc gccgccagcg tcggcgtcct ctacgggtac gacctttccg
3717301 ccatcgcggg tgcgttgctg tctctcagcg aggaattcga actcaccact cgagaacagg
3717361 agttgctgac caccacggcg gtgctcggcc agatcgccgg ggcgcttggc ggcggcatcc
3717421 tcgccaacgc gatcggacgc aagaaatcgg tggtgctcat cgtcgccggc tacgcagtgt
3717481 tcgccctgct cggcgcgacc tcggtgtccg taccgatgct ggtggtggcg cgtctgctgc
3717541 tgggtgtgac aatcggcctg tcggtggtgg tggtgccggt gtatgtggcc gagtcggcgc
3717601 cggcggcggt gcgtgggtcg ttggtgaccg cgtatcagct ggcgacgctt agcggcatcg
3717661 tcgtcggtta cctggtcggc tacctgttgg ccggatcgca cggctggcgc gcgatgttcg
3717721 ggctggccgc cgcgccggcc acgctgctgt tgccgttgtt gtggcgcatg cccgataccg
3717781 cccgctggta tctgctcaag ggccggatcg ccgacgcgcg tagcgcgctg cggcggatcc
3717841 agccggaggc cgacatcgat gccgagctgg ccgatatggc ggccgcggtc gacgaacgcg
3717901 gcggcggtat cggcgaaatg gtgcggcggc cgtatctgcg ggccacgctg ttcgtcatcg
3717961 cgctcggctt cctcgtccag atcaccggga tcaacgcgat catctactac agtccgcgac
3718021 ttttcgccgc catgggcttc gcgggctatt tcgcgatgct tgccctgccc gcgatggtgc
3718081 aagtcgccgg cttggcggcg gtgtgtgcct cgctgtttct ggtcgatcgg ctgggccgtc
3718141 gcccgatcct gttgtccggc atcgcgacga tgatcaccgc agatgccgtg ctgatcaccg
3718201 tattcgccaa cgactccgat ggtggcacgg ggctggtgtt ggggttcgcc ggcgtgctgc
3718261 tgttcatcat cgggttcaac ttcggattcg gctcgctggt ctgggtgtac gccgcggaga
3718321 gcttcccgtc ccggctgcgg tcgatgggat cgagcccgat gctcacctcg acactgacgg
3718381 ccaacgcgat cgttgccgcc ttctcgctca ccatgctgcg tgtgctcggc ggcgcaggcg
3718441 ttttcgcggt cttcggcacg ttcgccgtcg tcgcgttcgt ggtcgtgtac cgctttgcgc
3718501 cggagaccaa gggccgcaaa ctcgaggaga tccggcactt ctgggagaac ggcggccgct
3718561 ggcccgccga gcggtcaccg gcggcggacg aaccgtgacc gtgctcggcg ccgacgccgt
3718621 cgtcatcgac ggccggatat gccggccagg gtgggtgcac accgccgatg gtcggattct
3718681 ctccggtggc gctggggcac cgcccatgcc ggccgacgcg gaattccccg atgcgatcgt
3718741 ggtgcccggc tttgtcgata tgcatgtgca cggcgggggc ggcgcgtcgt tcgccgacgg
3718801 caacgccgca gacatcgccc gtgcggccga gtttcacctg cggcacggca ccactaccac
3718861 gctggccagt ctggtcaccg cgggccccgc cgagttgctc tccgccgtgg gcgctttggc
3718921 cgaggcaact cgggacggcg tcgtcgcggg catccatctg gaggggccgt ggctgagccc
3718981 agcgcggtgc ggagcgcacg accacacccg gatgcgtgcc ccggatcccg ccgagatcga
3719041 gtcggtgctc gccgccgccg acggcgccgt ccggatggtc acgttggcac ccgagttgcc
3719101 cggaagcgat gcggcgatcc ggcgcttccg tgacgccgaa gtggttgtcg ccgtggggca
3719161 tacggatgcg acctacacac agacccgaca cgccatcgac ctgggcgcga cagtcggcac
3719221 ccacctgttc aacgcgatgc cgccgctgga ccatcgggcg cccggacccg tgctggcgtt
3719281 gctgtgcgac ccgcgggtga ccgtcgaaat catcgccgac ggcgtgcacg tgcaccccgc
3719341 ggtggtgcac gcggtgatcg aagccgtcgg tcccgatcgg gtcgccgtgg tcaccgacgc
3719401 gatcgccgcg gccggatgcg gcgatggcgc gttccggctc ggcacaatgc cgatcgaggt
3719461 cgagtcgagc gtggcacggg tggctggtgc gtcgacgctg gcgggcagca ccaccaccat
3719521 ggatcagctc ttccggacgg tggctgggct cggctcgaag tcggactcag ccggcgatgt
3719581 ggcgctggcc gccgcggtgc aggtgacctc ggcgacgccg gcccgcgctc tcgggctcac
3719641 cggggtgggc cggctggcgg cgggctatgc cgccaatctt gttgtgctgg accgtgatct
3719701 gcgggtgacg gccgtcatgg tcaacgatga ctggcgggtg ggctgagcgt ccgtggaggc
3719761 ccgtcacaat gcccaggctc gcaccgtgag tactcggtca acgttgacgg ttgccccggc
3719821 gacccggtca ctctggcgag ggctaccggc gccgcgcggc ttgtaccgca atcatccgat
3719881 cgccgcgaag cgctcggcag ccggcttggg cggtagccga cgacacgggt acggtctcac
3719941 ggcgcgagcc tgataaagcc cggcggcatg ggtcgtgcag gcgacggctc taccggtccg
3720001 tcaccaccgc cgccaccacc gctgccggcg ccgccactgc cggcagcgcc cccggactgc
3720061 ggaacaccag caggcggctc aacctctggc ggcgggggcg gcggctgttg cggcggcgct
3720121 ggtcgcggtg gcggcggtgc cacgatcggc gggggtggaa tcagggtctg cgccgccggc
3720181 ggcggtaccg gaatcggcgg cggattcggt atcaggggat cccccgcgcg aaccgctccg
3720241 agcaccgagg caagcatcgc acccgtcggt tcccgccatc ccggcgacat gatggtcatg
3720301 tccgacaccg acgcccgcag gtcgcttccc gagttgaccg cgctgcgcgt ggacgccgca
3720361 acgcgatgcg tcggttcatt cgatcccggc tcgaaattgg ccatggcgaa cgccatcttg
3720421 ctgtgatggt tcgggcagta gatctccact gccgcactga taaatcgggt catggtcgtc
3720481 gtgaggcgga cagggtagag gcgcatgacc gggtctatgt tgtaggcatc gttgcgtaac
3720541 ccgtccacaa tgtcgttcac cggcatgccg ccatcgagtt tgcgacacac tttgtgggcc
3720601 gcgtcgatga cgcgaggcac attcgcgacg gcggggattt cctttttctc gagcagcgcc
3720661 agaaaccgat cgtcttggtt tgggtcggcc gctgctgggc cgtcgtgcag aattgcggcg
3720721 ccgatcagca ccactaaggc ggcacccagg gcgccggcat ggctagcgat gccggtgaac
3720781 atgatggggt ttccgttctg ctaaaagccg ttacctggcg ggctttggat cgcgatccac
3720841 gccataggtg tggctgtctg gtcaggtttg accggcgcca tgatgtcgtt tcacagcgcc
3720901 gatgcagtct gggaggggac cagggcatgg gtgcattgag gagccagatc cagagaacca
3720961 caccggagcc gctggccgag gctcatccac aagccttcga tcccgctccc gttgtcggca
3721021 tgggcgcctg ccgacggaat cagcggatgg tcatagtggc gtcgggcgcc aggcctgcgc
3721081 gggcacacgc ggtgcggtgt cgatggttgt tctcatctgg taactccttt ccgcaggccg
3721141 caattcagcg gtatgggctc accgagatca ggctcgtcac gatcgcccgc actgctggcg
3721201 gctcacatgt acccagtgtt aaccttctag tgcactagaa ggtcaagggg agtcgcatga
3721261 agatcagcga ggtagccgcg ctcaccaaca ccagcaccaa gaccctccgc ttctacgaga
3721321 actcggggct gctgccgccg cctgcacgca cagcatcggg gtatcgcaac tatggacccg
3721381 agatcgtgga tcggctgcgg tttatccatc ggggccaagc ggccgggctg gcattacagg
3721441 aagtacgcca aatcctggcc atccacgacc gcggcgaggc gccgtgcgca cacgtccgcc
3721501 aactactgag cacccgcatc gacgaagtcc gcgcgcagat cgccgaactg attgccctcg
3721561 aaggccactt gcagaccctg cttgaccacg cttcatatgg cccgcccacc gaacacgacc
3721621 actccacggt gtgttggatc ctggaaagcg acctcgatga gcccaccgcc atcgaggtca
3721681 gcgacattca cgcctagagg tcgctgggta cgcgggctgg cccacgggtt ttacgccgaa
3721741 gccgtcgccg cccacgcggt ggcgaacagg atcagccacg cggtgacgaa cgcgaacacc
3721801 atcaagccca gcaccggccc gaacaccgcg cccgccgggc tgcgcaacac tatctgcagg
3721861 tagatcgccc ccacctgctt gaacagctcg aagccgaccg ccgccatcaa cccggcccgc
3721921 gccgcggtga ccaaaccgac cggctcccgc ggcagccggc caatcatcca ggtgaacagc
3721981 acccacgaca ccagcaccga taccagcacc gagatgcccc gaaagatctc gtcgaacact
3722041 gaaaactggg gtatttcaag ccatctcagt accgcagcca tcggcctggc atggccgagc
3722101 acggtgagcg cgatggtggc cacgatcacc acgaacgtcc ccaccatggc cgctagatcc
3722161 gacagtttgg tgcgcaagta gcccgccgga gcgactggat gtgcccacat ctggctcaac
3722221 gcttcccgca ggtgccacat ccagcccagg cccacccagg ccgcggtcgc cagaccgatc
3722281 accccgaccg acgcgcgtgc atcgatcgcc gaattcatca ggtcgaccag ctgctgtccc
3722341 accgcaccgg agaccgaggt gcggatgcgc tcctcgagcg tggtcagcag ctccggacga
3722401 cgcgacaacg cgaatccacc caccccgaaa ccgaccatca gcaaaggaaa tatcgcaaag
3722461 atcgtgtagt aggtgagtcc ggccgcaaaa agactgccgt tgcgatcgtt aaagcgcgtg
3722521 aacgcacgca cgacatggtc caaccacccg aaccgggccc gcagccggtc aagcacccct
3722581 ggctcggcga gctcgcccat gatcgactgc cctacccccg ttatagaagg aacccgagcc
3722641 gatcgtagac tcgctgaacc gttttgctgg ccacatcgtg ggcgcgctgc gccccggcgg
3722701 cgagcacggc ctccagctcc gcgggatctg cggtcaattc gtcaactctg gcttggatcg
3722761 ggttgacgaa ttcgacgacg gcctcggcgg tgtctttctt caaatcgccg tagccgtgtc
3722821 cggcatagcc gtcgacgaga acgtcgatgt cggtcccggt gaccgccgac tggatgttca
3722881 acaggttaga cacccctggc ttgacgtccg ggtcatagcg gatgtcacgt tcgctgtcgg
3722941 tcacggcgga gcgaatcttc ttggcggaca atgccggatc gtcgagcagg ttgatcaaac
3723001 cggcatcggt gcccgccgat ttgctcatct ttgacgtcgg gtcttgtaga tcgtagattt
3723061 tggcggtcat cttggggatg agcacgtcgg gaaccaccag ggtgccgggg aatcggctgt
3723121 tgaaccgttg cgcgacgtcg cgggccagct cgaggtgctg ccgctgatcc tccccgacgg
3723181 gcaccagctc ggtgtcgtag gccaacacgt ccgcggcctg cagtaccggg taggtgaaca
3723241 ggccgacggt ggtggcctcg ctgccctgac gcgccgactt gtctttgaac tgggtcatcc
3723301 gcgacgcctg gccaaagccg gtgaaacaac ccagcaccca cgccagctgg gtgtgagccg
3723361 gcacctgact ttgcacgaag atggtggcgc ggccgggatc gattcccaac gccaggtatt
3723421 gcgcggcggt aatcagggtc cggcgccgca gtgcctcggg atcctgaggg atggtgatcg
3723481 catgcaggtc gaccacgcag aagaacgcat cgtggtcatc ctgcaagcca acccattggg
3723541 cgacggcgcc caaggcatta ccgaggtgaa gcgagtcaga cgtgggctgc acgccggaga
3723601 agatccggcg ggacccggta ggggtgctca tgatgccccg atcctttcac gcggggtgcc
3723661 ctccccgtcg accaccggtc accacgctgc ttgcggtacc ggcggtaccg gctttagtgt
3723721 cggctctatg cgcagtccga tacgcgtggg ttcgggagag ccggtcctac tgctacaccc
3723781 gttcttgatg tcccaaacgg tgtgggagaa ggtcgcccag cagctggccg acaccggccg
3723841 cttcgaggta tttgccccca cgatggccgg ccacaacggc ggaccggcct cgggcacccg
3723901 gttttgtcct cggcggtgct ggccgaccac gtcgaacgcc agctcgacga actgggctgg
3723961 gaaaccagcc atatcgtcgg caactcgttg ggcggctggg tcgcgttcga actcgaacga
3724021 cgtggccggg cacgcagcgt gaccggtatc gccccggcgg gcggttggac ccgctggagt
3724081 ccggtcaagt tcgaagtgat cgctaagttc atcgcagggg cgccgatctt ggccgtcgcc
3724141 cacattcttg gccaacgggc gcttcggctg ccgttcagcc gcctgctggc caccctgccg
3724201 atcagcgcca caccggacgg cgtgagcgag cgcgagctgt ccggcatcat cgacgacgcc
3724261 gcgcactgcc cggcctattt tcagctgctg gtcaaggcgc tggtgctgcc cgggctgcag
3724321 gagttggaac acaccgccgt gccctcgcac gtggtgctgt gcgagcagga ccgggtggtc
3724381 cctcccagca ggttcagccg tcatttcacc gactcactgc cggcgggcca ccggctcacc
3724441 gtgctcgacg gcgtcggtca cgttccgatg ttcgaggctc cggggcgcat cactgagctg
3724501 atcaccagct tcatcgaaga gtgctgcccg catgtccggg ccagttagcg ggcgcgagca
3724561 gacgcaaaat cgcccatttc ggcacgaaat tgggcgattt tgcgtctgct cgccctaatt
3724621 ggccagctcc ttttccaggt tgtcggcgat cgcatcgagg aattcctcgc tattcagcca
3724681 gtcctgctcc ggaccgatga ggatcgcgag gtccttggtc atcttcccgc tctccaccgt
3724741 ggcgatgacg acggactcca gcttgtgggc gaagtcgatg acttcgggag tgccatccag
3724801 cttgccgcga tgctgtaatc cgcgggtcca ggcaaagatc gacgcgatcg ggtttgttga
3724861 ggtcggttta ccggcctgat actgccggta atgccgggtg acggtgccgt gggcggcttc
3724921 ggcctcgact gtcttgccgt cggccgtcat cagcaccgac gtcatcaggc ccagcgagcc
3724981 gtagccctgt gcgacggtgt ccgactgcac gtcgccgtcg tagttcttgc acgcccagac
3725041 gtaaccgcct tcccatttca ggcaggcggc gaccatgtcg tcgatcaacc gatgctcgta
3725101 ggtcagcccc gccgcttcga actgcgcctt gaattcctct tcgtagacgc gctcgaactc
3725161 gtctttgaac atcccgtcgt aggccttgag gatggtgttc ttggtggaca gatataccgg
3725221 ccatttcgcg ttgaggccgt aggagaacga cgcgcgcgcg aaatcccgga tggattcctt
3725281 gaagttgtac atccccagca cgacgccgcc gtcctcgggg atggacacca tttcgtgcac
3725341 gatcggcgcg ctgccgtcgg cgggcgtgaa agtcagtgtg acggtgcccg gttggtcgac
3725401 cttgaagttc gtcgcccgat attggtcacc aaaagcgtgc cggccgatga cgatcggctt
3725461 ggtccacccc ggaaccagtc gcggcacatt agaaatcacg ataggttcgc gaaagattgt
3725521 gccgcccaag atgttccgga ttgtcccatt gggcgacagc cacatcttct tcaggttgaa
3725581 ttcctcgaca cgggcctcgt cgggggtgat cgtcgcgcac tttacgccca caccgtgttt
3725641 cttgatcgca tacgccgcgt cgatcgtcac ctggtcgtcg gtggcgtcgc ggtgctcgat
3725701 gcccaagtcg taatagtcca agcggatgtc gagataggga aggataagca tgtccttgat
3725761 gagcttccag atgacacggg tcatctcgtc accgtcgagc tctacgaccg gaccgctgac
3725821 ttttatcttg ggtgcgttgg acatgggagt ccacatcaga ttactagcag cccgcgcggg
3725881 cccctagcgg ccggtaaagg gccagttgag accgccggag ttgtgctttg agttggcact
3725941 gagtagctgc catgcgctag gcttcgagtc ggtcatgagc gccagcgtca agccccggct
3726001 tgctggccgg caaccctcca accgcggtgg ggtgccccgg gtgatgacca ggttgagtag
3726061 ccatcgccgg ctgcgcggca agcgcgggtc cgccatgacg ggcccctgac cagacgggga
3726121 aagctcatga gcgccgacag caatagcacc gacgccgatc cgaccgcgca ttggtcgttc
3726181 gaaaccaaac agatacacgc tggtcagcac cctgatccga ccaccaacgc ccgggctctg
3726241 ccgatctatg cgaccacgtc gtacaccttc gacgacaccg cgcacgccgc cgccctgttc
3726301 ggactggaaa ttccgggcaa tatctacacc cggatcggca accccaccac cgacgtcgtc
3726361 gagcagcgca tcgccgcgct cgagggcggt gtggccgcgc tgttcctgtc gtcggggcag
3726421 gccgcggaga cgttcgccat cttgaacctg gccggcgcgg gcgatcacat cgtgtccagc
3726481 ccgcgcctgt acggcggcac ctacaacctg ttccactatt cgctggccaa gctcggcatc
3726541 gaggtcagct tcgtcgacga tccggacgat ctggacacct ggcaggcggc ggtacggccc
3726601 aacaccaagg cgttcttcgc cgagaccatc tccaacccgc agatcgacct gctggacacc
3726661 ccggcggttt ccgaggtcgc ccatcgcaac ggggtgccgt tgatcgtcga caacaccatc
3726721 gccacgccat acctgatcca accgttggcc cagggcgccg acatcgtcgt gcattcggcc
3726781 accaagtacc tgggcgggca cggtgccgcc atcgcgggtg tgatcgtcga cggcggcaac
3726841 ttcgattgga cccagggccg cttccccggc ttcaccaccc ccgaccccag ctaccacggc
3726901 gtggtgttcg ccgagctggg tccaccggcg tttgcgctca aagctcgagt gcagctgctc
3726961 cgtgactacg gctcggcggc ttcgccgttc aacgcgttct tggtggcgca gggtctggaa
3727021 acgctgagcc tgcggatcga gcggcacgtc gccaacgcgc agcgcgtcgc cgagttcctg
3727081 gccgcccgcg acgacgtgct ttcggtcaac tatgcggggc tgccctcctc gccctggcat
3727141 gagcgggcca agaggctggc gcccaaggga accggggccg tgctgtcctt cgagttggcc
3727201 ggcggcatcg aggccggcaa ggcattcgtg aacgcgttga agctgcacag ccacgtcgcc
3727261 aacatcggtg acgtgcgctc gctggtgatc cacccggcat cgaccactca tgcccagctg
3727321 agcccggccg agcagctggc gaccggggtc agcccgggcc tggtgcgttt ggctgtgggc
3727381 atcgaaggta tcgacgatat cctggccgac ctggagcttg gctttgccgc ggcccgcaga
3727441 ttcagcgccg acccgcagtc cgtggcggcg ttctgaggaa ttctgacatg acgatctccg
3727501 atgtacccac ccagacgctg cccgccgaag gcgaaatcgg cctgatagac gtcggctcgc
3727561 tgcaactgga aagcggggcg gtgatcgacg atgtctgtat cgccgtgcaa cgctggggca
3727621 aattgtcgcc cgcacgggac aacgtggtgg tggtcttgca cgcgctcacc ggcgactcgc
3727681 acatcactgg acccgccgga cccggccacc ccacccccgg ctggtgggac ggggtggccg
3727741 ggccgggtgc gccgattgac accacccgct ggtgcgcggt agctaccaat gtgctcggcg
3727801 gctgccgcgg ctccaccggg cccagctcgc ttgcccgcga cggaaagcct tggggctcaa
3727861 gatttccgct gatctcgata cgtgaccagg tgcaggcgga cgtcgcggcg ctggccgcgc
3727921 tgggcatcac cgaggtcgcc gccgtcgtcg gcggctccat gggcggcgcc cgggccctgg
3727981 aatgggtggt cggctacccg gatcgggtcc gagccggatt gctgctggcg gtcggtgcgc
3728041 gtgccaccgc agaccagatc ggcacgcaga caacgcaaat cgcggccatc aaagccgacc
3728101 cggactggca gagcggcgac taccacgaga cggggagggc accagacgcc gggctgcgac
3728161 tcgcccgccg cttcgcgcac ctcacctacc gcggcgagat cgagctcgac acccggttcg
3728221 ccaaccacaa ccagggcaac gaggatccga cggccggcgg gcgctacgcg gtgcaaagtt
3728281 atctggaaca ccaaggagac aaactgttat cccggttcga cgccggcagc tacgtgattc
3728341 tcaccgaggc gctcaacagc cacgacgtcg gccgcggccg cggcggggtc tccgcggctc
3728401 tgcgcgcctg cccggtgccg gtggtggtgg gcggcatcac ctccgaccgg ctctacccgc
3728461 tgcgcctgca gcaggagctg gccgacctgc tgccgggctg cgccgggctg cgagtcgtcg
3728521 agtcggtcta cggacacgac ggcttcctgg tggaaaccga ggccgtgggc gaattgatcc
3728581 gccagacact gggattggct gatcgtgaag gcgcgtgtcg gcggtgacgt gctcccgacg
3728641 cgacatgtcc ctgtcgtttg gctccgcggt cggcgcctac gagcgcgggc gcccctcgta
3728701 tccaccggaa gccatcgact ggctgctgcc ggccgccgcc cgccgcgtgc tcgacctggg
3728761 agcgggcacc ggcaagctga ccacccggct agtcgagcgc ggcctggacg tggttgccgt
3728821 cgacccgatc ccggagatgc tggacgtgct gcgtgctgcg ctgccgcaaa ccgtcgcgct
3728881 gctgggcacc gccgaagaga ttccgttgga cgacaacagc gttgacgcgg tgttggtggc
3728941 tcaggcgtgg cactgggtgg atcccgcccg ggcgattccg gaggtcgccc gggtgttgcg
3729001 tccgggcggg cggctcggcc tggtgtggaa cacccgcgac gaacggctgg gctgggtgcg
3729061 cgagctgggt gagatcatcg gtcgcgacgg cgatccggtg cgcgacaggg tgacgctgcc
3729121 cgagccgttc actacggtgc agcgccatca ggtcgagtgg acgaattacc tgacaccaca
3729181 agcccttatc gacctggtgg cttcgcgcag ctattgcatc acctcaccgg cgcaggtccg
3729241 caccaaaacg ctcgaccggg tgcggcagtt gctggccacc catccggcgc tggcgaatag
3729301 caacggcctg gcgctgccct acgtcacggt ctgtgtgcgg gcgactctgg cctgacgccg
3729361 cctttagggc ccggtgccgg tgtaaatcag gcccgccagt tgctggccga cgttgccgaa
3729421 gccggagacc agggccgagg tgatcaggcc cagcgcgccg gtgttgtaca cacccgagat
3729481 gtccgcgccg cggttgagga tgccggagag ttgggtgccg aagttggcga agcccgacgc
3729541 cgatccgagc agcggatccg agatcgcgtt gagcacgccc gacatgcccg cgccgaggtt
3729601 gtggaagccc gacaacccgc cgccaccgcc gatgttgaag aaccccgacg acgggaccgc
3729661 ggtggtgttg ccgaatcccg ggacgggcgg gatgaccaac ccggcgttga tggggccgag
3729721 cagcgcgttg acgtcgagaa ccactgggat tcggtcgatg gtgatctcca gagggaaggc
3729781 gaaggcgggg gtggcgccgg acaacgcgag gcccagcggg agttggggaa tggtgatttc
3729841 cgggctcacg aagggtccga tggtgacgga caggggcagc tcgacatgga ttggatcgac
3729901 gggtatgtgg aatcccggga tggtgatttc cggtgttaga tgggtcacgc caagcgaact
3729961 cagcagcacg gtgaatggca gaatctcgct gggcgccgtt tggatggcgg ggacattaac
3730021 gttgatgaac cccagcagcg taaggctgaa tggatcgatg atggagcctg agctgaatat
3730081 cgggcccacg gtgacaccgg ttgcggggtc gagtcccagg gcgggaatcg tgatgtcctg
3730141 gacggtgatg gggccgaggt cgaagactgg gtcgatgcga accgtgatcg gggaaatgga
3730201 caccggcggg atggtgaagc cgccgatgtg gccggttgcg ctgaggtcca agggaattgc
3730261 cggaaattgg atcgacggaa cgatgatggg tccggcgccg ccggacgcgt ggatgttcgc
3730321 gacagtgaat tcgggaatga tggtgctggt gtaggagaag ccgagcaggc cctggtagtc
3730381 gccccgccag aaggcgccgt tgctgtagtt gccggagatg aaggcgccgg tgttgacgtc
3730441 gccggagttg gccaccccgg tgttgatgtc accggtgttc aaccaacccg tgttgacact
3730501 gcccgggttg aaaccgcccg tattggcctg ccccgcgttg aaactgccgg tgttgtagct
3730561 acccgcattg accacacccg tgttgaaccc acccgcgttg aacaaccccg tgctggcaat
3730621 ccccgaatta ccgatcccgg tgttataact ccccgaattg aacacccccc agttcccggt
3730681 gccagagtta aagaacccca cattaccggt ccccgaatta aacaacccca cattcccgct
3730741 gccggtattg aaaccaccga acccggtcag attatcaccg gtcaacccaa taccgaaatt
3730801 cccactgccg gtgttagcga acccaatatt gcccacaccc atattcgcca aaccgaaatt
3730861 gtagctgccg gcattaccaa acccgatatt acccaaaccc atcagacccg gcgttaaccc
3730921 cgaattcccg agcccaaagt tgccccaccc gacattgccc aacccgacat tgttgccgcc
3730981 gatattgccg ccacccacat tgaacccacc gacgttgccc gcacccaggt taaagtcccc
3731041 gacattgccc aacccgacat tgcccaaccc cacatcggcc aacccgaaat tgaggaccag
3731101 accctgatgc agcgccgtcc cgctcgccaa caatcccgac aactgctgac cgacactacc
3731161 caaacccgac accaacgccg gcgcacccaa ccccaacacg ctggtgttga acagccccga
3731221 catgccagag ccgaaattca gcacacccga atgcagcgtg ccggcgttga aaacacccga
3731281 acccccaccc agcaacgccg acggagcctg attccagcca cccgacacca tcgcgccgac
3731341 attcccaaac cccgacaccc cacccgcacc ggagttgaag aaacccgacg acggagcacc
3731401 ggtcgtattc ccgaaccccg gcacggcggg aaggtcgatg aggatgtgaa cggggccgag
3731461 cgtgctgtgg gccacgaggt caaaggggat ttcgccgatg gtgattgccg gaatggtgac
3731521 ggcgccggtg ccaccggaca ggttgatgct cagcgggttc atcgcgggga tcgtgaggcc
3731581 gcccgggaag atgtcgacgg gctcgctgtg gccggtaatg ctggccagca gcgggatctc
3731641 gtcaatggtg acgacggggg tgctgaacgg caggttggcc aggaaagccg tgatggtccc
3731701 ttgcgacgag ctagcaccga tgactatctg gcttaacgcc aggggggtaa ggccgatggg
3731761 ggtgttgaag agtcccgtaa tcggaccgat tttcaggggc ccgccgggtt gtgagccaaa
3731821 caagtaattc agcgtgacgg gcacccgtgg aatatcgagg tgcgggacgg tgatggggcc
3731881 gaggccgacg ctgaccgtgg tggcggccag gtcgatctgg ggaatcggga tgctcggcac
3731941 agtgaagctg tcgatggcga cgttggcgct gaactcgggg cggatcgcgg gaatgtcgat
3732001 ggcggggata acgacggagc ccagtccgcc ggtgagggtg aggtccagga acggcgtttg
3732061 gggaagcacg gcggggcggt aggagaagcc gagcaggccc tggtagtcgc cccgccagaa
3732121 ggcgccgttg ctgtagttac cggagatgaa ggcgccggtg ttgacgtcgc cggagttggc
3732181 caccccggtg ttgatgtcac cggtgttcaa ccaacccgtg ttgacactgc ccgggttgaa
3732241 accgcccgta ttggcctgcc ccgcgttgaa actgccggtg ttgtagctac ccgcattgac
3732301 cacacccgtg ttgaacccac ccgcgttgaa caaccccgtg ctggcaatcc ccgaattacc
3732361 gatcccggta ttataactcc ccgaattgaa caccccccag ttcccggtgc cagagttaaa
3732421 gaaccccaca ttaccggtcc ccgaattaaa caaccccaca ttcccgctgc cggtattgaa
3732481 accaccgaac ccggtcagat tatcaccggt caacccaata ccgaaattcc cactgccggt
3732541 gttagcgaac ccaatattgc ccacacccat attcgccaaa ccgaaattgt agctgccggc
3732601 attaccaaac ccgatattac ccaaacccat cagacccggc gttaaccccg aattcgccaa
3732661 cccgacattg ccaaacccga cattgcccaa cccgacattg ttgccgccga tattgccgcc
3732721 acccacattg aacccaccga cgttgcccgc acccaggtta aagtccccga cattgcccaa
3732781 cccgacattg ccgccaccga ggttgctcaa ccccacgttc gggccgacga tcccgaccgc
3732841 ggaattgaag cccgagatca ggttgttggc gatgctcccg tcgaacaggc ccaacagtcc
3732901 cacacccagg cccgggacag ccaaaccgct gaagggatcc gacgtggtgg tggtggagtt
3732961 ccctgagccc ggctcggtga tgatcgggat gttgatgggg cccaccggga ttgtgacgtc
3733021 cacgttcagc ggaattgcgg gcagcacggt ggccgggatg aagacggcgt cctcgaggtt
3733081 gatggacacg tcgataggca ggatttcgtg cagaatcatt gactttacgg tggatgccgg
3733141 ggaaccgaaa gagaagttga gcggtatgga ttcactgaca gtgggcaacg ggatactgag
3733201 tcccgccatg gtgatgggaa tagaacttcc cggaattaca atcggattca gttcgatgcc
3733261 gtctctgaag tcaaacaaga aaagagtctg accgaccgac atgaacagct gggcgggctg
3733321 ggtctgtata ttcgtgattt ggattccgga gatatcgatg cttcccgtga tgcccaggcc
3733381 ggacagcagg gtagtggccg gggcgttaaa actcacattg acgtttccgt cgaggccaaa
3733441 attgatggcg gggatgggga tgtccgggac ggtaaagggg ccgacctcga ggtttcccgt
3733501 gacggtcagg aggggattta gcgcatccac aacggtggtg gtcgggatgc tgatggggcc
3733561 gatgccgccg ttgagggtga agtgaaatgg aaacagcccg ctggtgaggc caaagccgcc
3733621 tgggaccgcc ggaatggggc cgttggccgg ggttggcggg atgtagtccc accggaacgg
3733681 gaaagggcca atagaaaggg tggtgtgcag gtccaccggg atgcggtcaa ccgtgaaacc
3733741 ctgcgggaac acggtgaatc caccggtgcc gacggagaag ttggtgaggc tgaccacggg
3733801 gttttccggg aacgccaggc cgcccgggaa tagcgtgatg ctgtccaggc cgccggtcag
3733861 gttgacggtc accggtgttt ggtcgggaac ggtgaggccg gccgggaaca aggccaagga
3733921 cgatgtggac agattgaaag tcgcgccgaa cgggccgggg atcgtgcccg ggccgccgta
3733981 gctgccgatg atgggtccat tgatctgcag gtcgctgatg ctgaggtaga acgacccgga
3734041 ggggaatttc gcgccgggtg ggcctagcgg cgggccgtag tggtcgatcg tgatgaacgg
3734101 gtccggcaag acgaccgggt ccgcggtgat ttctgccatg gcggtttgcc cgaaaagaac
3734161 aaacgcggga ttcacgtgaa aaccctcgag gccgacggtt ccggtcacgt ggatcgggat
3734221 cgcgggaatg gtgatctccg ggagagtgaa ttcgcggatc ccgatgaatc ccccggtgat
3734281 ttgtatgtcg aatgccggaa tatcgatggg ctggacgtgg atgggaccga tcccgccaat
3734341 cacctgcagg tcaatgggga tttcggaaat ggtgaaaagg gtgccggggg tgaagggggc
3734401 caggacgttg atgttgttgc ccgttaagaa gaaaccggtg ttgtggcttc ccgaattgaa
3734461 tacgcccaaa ttcccggtgc cggagttgaa gaacccgaca ttgccggtac ccgaattgaa
3734521 caatcccaca ttctcgctgc ccgaattgaa accaccgaac ccagtcagat tgtccccgct
3734581 gagcccgata ccgatattcc cgttgccggt attggccaac ccgatgttgc cgatgcccat
3734641 gttcgccagg ccgaaattgc tgctgccggc attgccgaac ccgacgttgt cgaacccgat
3734701 attgcccaat ccgaagttgt tgccgcccag cgcgccgccc gacaacatcc ccgacaactg
3734761 agtacctaca ttgccgatac ccgacatcaa cgtgccggag ttgaaatagc ccgaaaccgt
3734821 tcccggcaac acctgcatgg cctgggtgga ctggttaaac cagcccgagg tgtgcgcgcc
3734881 gacgttcccg aatcccgaca ccccgccggc gccggtgtta aagaagcccg aggacggggc
3734941 ggtggtcgaa ttcccgaacc ccggcgacgc cggaacgttg ccgcccacga tgtcgacggg
3735001 cccgacgccg ccgatggcgt gcaggttcag ggggatgttg tcgatggtga ttgccggggt
3735061 gctcagggcg ttgatgtggc caatcacgtt gatcgccagc ggaagtggtt gctcgggaat
3735121 cgagaatccc ggaatggtga aggcctcggt gcctgccgtt acgccaagag tcagggtgag
3735181 cggccccccg gtgggaatgc tgaggccaac cgggaaaagg gtgagggctg gggtggaata
3735241 actgaaggtt actgggatgg aaaacccggt attgatatgt attgggccga tcaaggttgt
3735301 gggaatgggg gaagggctga gggcgacctg ttggatttgg ggaattgtta tggacgagac
3735361 gggccaggcc agcgtgatgg tttggttgaa gttttgtgcc ggccacaggg tgatgggatt
3735421 gattttgatg gggccgatcg aaatattggg tatgccgacg ccgagcgaga ttgccgggac
3735481 gttgatgggc gggacgacca agggtccgag gtagagggtt tcgttgatgt tgatcgggat
3735541 gtcgggaagt atgtggatgg gctcgatagt gatggcgccg acaccaccgt ttatgtccag
3735601 gctgagggga atgacaggaa gaacgttcgc tcccgaggag aagccgagca ggccctggta
3735661 gtcgccccgc cacaagacgc cgttgctgta gttaccggag atgaaggcac cggtgttgac
3735721 gtcgccggag ttggccaccc cggtgttgat gtcaccggtg ttcaaccaac ccgtgttgac
3735781 actgcccggg ttgaaaccgc ccgtattggc ctcccccgcg ttgaaactgc cggtgttgta
3735841 gctacccgca ttgaccacac ccgtattgaa cccacccgcg ttgaacaacc ccgtgctggc
3735901 aatccccgaa ttaccgatcc cggtgttata gctccccgaa ttgaacaccc cccagttccc
3735961 ggtgccggag ttaaagaacc ccacattacc ggtccccgaa ttaaacaacc ccacattccc
3736021 gctaccggta ttgaaaccac cgaacccggt cagattatca ccggtcaacc caataccgaa
3736081 attcccactg ccggtgttag cgaacccaat attgcccaca cccatattcg ccaaaccgaa
3736141 attgtagctg ccggcattac caaacccgat attacccaga cccatcagac ccggcgttaa
3736201 ccccgaattc ccgagcccaa agttgcccca cccgacattg cccaacccga cattgttgcc
3736261 accgatattg ccgccgccca cgttgtagct cccgacgttg ccggccccca cgttgtagct
3736321 gccgacgttg ccgcttcccg cgttgaagag gccaacgttg gccaaaccca gattgacggc
3736381 gagcgacttg gccggctcgg cggcggccgc caggcttgcc agcggcgagc caaacggcgc
3736441 caacgcctcg gccgccgccg aggcgccggt gtggtacccc agcatcgcgg ccacgtcctg
3736501 ggcccacatc agctcgtagt cgaactccgc ggccgcgatc gccggcgtgt tctggccgaa
3736561 cagattcgat aacgccagcg acactaacct cgaccgattg gccgcgatga cgaaggggtc
3736621 caccgtctcg gccaacgccg cctcgaacac acccaccacc gcccgggcct gcccggccgc
3736681 cgactcggcg gaggccgccg ccgcgctcaa ccaccccgca tacggggcgg ccgccgccgc
3736741 catcgcgacc gaggacggcc cctgccagat accaccgacc agccccgagg tcaccgaccc
3736801 gaaagccgcc gccgccgagc ccagctcggc ggccagctca tcccaggccg cggccgccgc
3736861 caacaggggg cccggacccg ccccggtata tatcagcagg gagttgatct ctggcggcat
3736921 tacgacaaaa ctcatgccgc cagccctttc ccgtgcgttc ccaacatcgc tgtcaaccgg
3736981 tgatcagggt gttgcgccgg cgccgccgag gccgccgtcg ccgccgaacc ctggctccgt
3737041 gcctgagttg ggctggccgg cctgcccttt gccgccggcg ccgccggcct tggcgccgct
3737101 gttgccgccg ttgccgccgt caccgccgtc accgccgtca ccgccgaggc cggtcgcgct
3737161 ctgagtgccg ccgccaatgc cgccctggcc acccttaccg ccgttgccac cgaagccgcc
3737221 gtccggggcg ttgcctccgc caccgcccgc gccgccaagg ccgccgttgc cgccggtgga
3737281 gccgccgcca ttgccgccct gcccaccgag gccgccctgg ccgccggcac cggcaaagac
3737341 gccgtcgccg ccccggccgc cgacaccgcc gttgccgccg ccaccggcca cggtgccgac
3737401 ggtaccgccg ccgttggggc cgccctgacc gccgtcgccg ccgaagccgc ccttgccgcc
3737461 gaaaaagccg ctgccgccgg cgccgccggc gccgccgcca ccgccgctgc cgccttgggt
3737521 gacggagctg ttgccgccga cgccgtcacc gccgtggcca ccgtcgccgc ccttgccgcc
3737581 ctcgccggag ctaaggctgc cgtttccgcc ggcgccgcca gcgccaccgg ccccaccgga
3737641 accgccgacg atgccgctgt tggcgccgat cgagcccccg ttgccgccgg caccgccgtt
3737701 gccgcccttg ccgccgtcgc cacctgagcc gttggggttg ctgccaccgg cgccgccctt
3737761 gccgccgttg ccgccggggg cgcccgtgac cccgatggag gcggggccgc tggtagcgcc
3737821 gaagctccca tcaccgccat tgccaccggc gccgcccttg ccgcctgagc cggtggcgtt
3737881 acccccggcg ccaccgttgc cgccggagcc gccggcgccg ccgcggctgc cgctgcccgg
3737941 gttggtggca ggcccaccgt ggtcaccgtt gcccccgtcg ccgcccttgc cgccaagcac
3738001 gacgccggtg ccgccggcgc cgccgttgcc gccgttgccg ccggcgccgc cgccaatgcc
3738061 gctgccgctg cccccggtgc caccgaaccc accctggcca cctgcgccgc cggcgccgcc
3738121 cgtgtcgccg ctgccgccgg cgccgccgtg gccgccgtta ccggcgttgc caccgcgagc
3738181 gttgccgttg ctggaaccgc cgttggcgcc agcgccgccc ttgccgcccg cgccgccggt
3738241 ggagccaggg ccgacaccgt cgccgccctt gccgccattg ccgcctgagc cggcgttgcc
3738301 ggcatcgcca ccgccaccgt tgccgccggc accgccgttg ccaccggcac caccggcgcc
3738361 gccgttgccg gccgagccag cgccgccgtt gccaccggca ccaccgctgc cgccgtgggc
3738421 cgccggactg gcctgtgctc aggctgcccc cgccagcacc ggcgccgccg ttgccgccgg
3738481 ccgcgccggc gccgcccgtg gtgccgctgc caccgctgcc gccgctgccg ccgtggccgg
3738541 cggcgctgga agtgccgccg ccgttgccgc cggcgccggc ggcaccaccg gccaagcccg
3738601 cgacgccggt gctgttgccg gagttgccgc cgttgccgcc gttgccgccg tcgccgccgg
3738661 tggcaccgcc gccgtggccg ccgttgccgg cgctgccgcc ggcaccgccc tggccgccgg
3738721 cgcccgcgga gccgttgccg ccgttgccgc cattgccgcc gttgccgccg tggccggcgg
3738781 tgacgttgac gacgcctgag ccgctggcgg caccgctgct gccgttgccg cccttgccgc
3738841 cggcgccgcc cgtcgtgccg tcgccgccgt ggccgccgtt gccgccgttg ccgccgtcgc
3738901 cgcccacagc gttgccgaag gacacgccgg cgacacccgc gttgccgccg gccccgccag
3738961 caccgcccgc gccgttgagg ccagtgcccc cattaccgcc ggcaccaccg gagccggcgt
3739021 tgccggtggt cgtgcttttg ctgctaccgc cgttaccgcc agcgccaccg gcccctccgg
3739081 caccgcccgc gtcggtgccg ataccgccat tgccgcccgc gccgccggag ccggcgtcac
3739141 cgcccaaacc gacgttcccg ccgtcgccgc cgttgccgcc cttgccgccg gcgccgccgt
3739201 cgccgcccgt ggtgctgacg ccgccgttgc cgccggcgcc gccgttgccg ccgaggccgc
3739261 cattgccttc ggggcctccc ggaccgccgt agccgccgtt gccgccggcg ccgccaaacc
3739321 cagtctcgga gacgccgccg ttgccgccga ggccgccgtt gccgcctaag gaaatgccgc
3739381 caccgccgtc gccgccgcta ccgccgttgc cgcctgtgcg cccttccccg ccgatgccgc
3739441 cctggccgcc gaagccgccg accccgccgg caccgccgtc cccgccggcg ccgccgacac
3739501 cgccaacacc gctagcaaag tcgcccgcgc cgccgggacc gccggcgccg cctgggccac
3739561 ccaacccggt gctagcgaag ccgccggcac cgccattgcc gccagcgccg cccgttgtcg
3739621 cggcgacgtc aacggcgccg ccaccgccgg cgccgccgaa gccgccgagg ccgccgttga
3739681 tcatgccggc accgccattg ccgccgttac cgcctttgcc gcccgtgccg aagaagccgg
3739741 cctggttcag cgccccaccg ccgttgccgc cgttgccggc gtcaccgccg ttgaggccgg
3739801 agccgccgtt gccgccgttg ccgccggccg cgccgctccc gttgccggcg gtgccgccct
3739861 tgccgccgtt gccgccattg ccgccgttac cgccgttggg ggtgatgccg tcggtgccgt
3739921 ccaagcccgt caaggagccg gtgccggcct tgcctccggt gccgccgacg ccggcgttgc
3739981 cgccgttgcc gccgttgccg ccggtaccgg ggtttcctac ggtgccgccg cccggcagca
3740041 tggccccgct gtttaggccg ttttcgccgg ccccgccgtc accggctttg ccgccatcgc
3740101 cgccgttgcc gccgtcgccg ccggtgcccg tggcgccgtc ggtgtacccg gccgcctgcg
3740161 ccttgccgcc cgcgccgcca ttgccgccgg cgccgccgtc gccaccgtta ccaccgctac
3740221 cgccgttctc gccgtttgcg ccgttagcat tggggccggc gccgtcggcg cctctctcgc
3740281 cggcgccgcc gatgccaccc tggccgccgt taccaccctt accaccgttg ccgccgtggc
3740341 cggccagtgt tccgccggcg ccgcccgccc cgccgttgcc gccagcccca ccgtcggtgc
3740401 ccgaggtgcc ggaatcaccg ctggtagggc ccggcgtacc ggcttggccg gccgcgccgt
3740461 tgccgccggc cccgccattg ccgccattgc cgacattccc gccgctgccg cccttgccgc
3740521 cgtcaccgcc gttgccgccc gcgacggtgg ggctggcgcc gttgccgccg ttgccgccgt
3740581 caccgccgct ggtgggtgcg gtgccatcgg cgccggtcgc acccttcatg gctggaatgg
3740641 cgcccttgcc gccggcccca ccctggccgg caacgcccac attgccgccg ttgccgccgg
3740701 caccgccgtt gccggcctta gcgaacgtgg cgaaggcgtc accacccttg ccgccgatgc
3740761 cgccgttgcc gccgttgccg ccctgtccgc cattcgcgcc attggcggac gcggagaagt
3740821 cttggccgtt ggctccggcg cccccgttgc cgcccttgcc gccgtccccg cccgtgccgg
3740881 ccgccgatcc gccgttgccg ccgatgccgc cgttgccgcc gttgccgccg ttgagggcaa
3740941 ggccggtgcc ggcgacgcca tttccgccgg caccacccgc accgccgtta ccgaccgacc
3741001 cgccatggcc gccgttacca ccggcgccgc cgttttctcc cgcgacggtg ggggtggcgc
3741061 cggcacctcc gttgccaccg ttgccgccgc tggtgggcgc ggtgccgttc gccccggccg
3741121 aaccgttcag ggccgggttc gcgctaacac cgccggcccc acccttgccg ccaacgccca
3741181 cttcaccgcc gttgccgccg tcaccgccgg caccctggtt gacggccaag gtcacatcac
3741241 cggcggcacc ggctccgcca tcaccggcct tgccgccgtc accgcccttg ccgccgttgc
3741301 cgcccatacc gccatcggca ccgggcgaac ccaaggtggc ggcgtcgaat ccgtttccgc
3741361 cggcgccgcc gctaccgccg gcaccgccct tgccgccgac gccgccgtcg ccgtgctggg
3741421 cgccgccatt tccgccatta ccgccgtggc ccccggcgcc gccattggtg ccgttaccgc
3741481 ccgtcggttg taaggcggta ccggtagcgc cggtggaacc cgcatgaccg gcaccgccgg
3741541 cgccgccggt gccgccgttg ccgaccaacc cgccatgacc gccattaccg ccggccccgc
3741601 cggcttgtag gggtgagttg gcggtggcgc cgatgccgcc atcgccgccg ttgccgccgc
3741661 tggtgggggt ggcgccggcg gcaccgtgcg cacccgccag caggccgccg gccccaccgg
3741721 ccccgcccac gccggggttg ccgccgtgac cgccgttacc gccggcaccg ttgttgacgg
3741781 cgaaactcgg atcgccagcg ccgcccttac caccgtcgcc gccgacgccg ccggccccgc
3741841 cggccccgcc gttgccaacc aataacccgc cgcgcccgcc gttgccgccg gttccgccgt
3741901 tgccgccgtc gctgccgtcg ccgccgttga ggccggcggc acccggcagg cccgcggccc
3741961 cggccccccc ggcgccgccg ttcccgaaca gcccggcgtc gccaccgttg ccgcctatac
3742021 ctccgatgcc gccgatcccg ccggcgccgc cgttgccgta gacaaatccg ccggacccgc
3742081 cgacgccacc attggtgccg gcgccgccgg acccgccggc cccgaacaac caggcgttgc
3742141 cgccggcacc accgttagcg ccggtcccgc cggccccgcc ggccccgccg ttgccgttca
3742201 accacccgcc ggatccgccg acaccgccgg cagcgccggc cccgccggac ccgccggacc
3742261 cgccgttgcc gaacaacccg gccgcgccgc cgggcccacc gacttgaccg gccgcccccg
3742321 aaccgccgtt accgccatta ccccacaaca accccccggc cccaccgggc tgcccggtcc
3742381 ccggcgcccc gtgaacgcca tcaccgatca gcgggcgccc caaccacagc tgtgtgggcg
3742441 cgttgatcgc acccaacact tgctgctcca gcgcctgcag cggtgatgca ttcgccgcct
3742501 cggcagtcgc atacgcgctg ccagccgcgg tcagcgagcg cacaaactgc tcatgaaacg
3742561 tcgccacccg ggcgctcaac gcctggtact cctgcgcgtg ggtaccaaac aacgccgcga
3742621 tcgccgccga cacctcatca ccggcggccg ccaacacctg cgtcgtcggg cccgctgccg
3742681 ccgcattcgc cgcgctgatg gcctgcccaa tcccggtcaa gtccgccgcg gccgccgcca
3742741 ccagctccgg cgccaccatc agcgacatga ccattcctcc aacaccaatg gcgcgtacag
3742801 ccggctcgcg cgagccttga ccgccggcgg caacccgagc gatcccatgg ccctaggcgg
3742861 ttctcgggcg aacgccacgt ttagcggatc gattcacccg gtcgttgcgt tgcggcgcag
3742921 caatagacat ctcgaagcac tccggctgcc aatctcgtcg cgtttattct gctcgtgacc
3742981 agcgcaggaa agggggggat tacgaaagtc ttcgggatct cagtgcacag tgcacacatg
3743041 tttaaccaat caccgtggca taacgcacac caaaggccga gagcgcggaa aacgcagaac
3743101 atcaattgga tcggttgcta gctttgccgc accgtggtca gccgcgccag gatcggtcgg
3743161 caatggcacc accggagcag gcgaaaggta cccggttcta gcccgtcccc aacgggtcaa
3743221 tggtggatgc gatatagacc atggccgccg cgaccgtcac ggtcgtcacg aaatcgatcc
3743281 ccttgctgcg caccaccaac aggccggccc gttcctcgga caacaccaac cgcagcaccg
3743341 ccgccacccc aacgccgata ccgatcagca gcgcaccacg gcgccagaag ttgacccccg
3743401 ccaggatcgg ccactgggcg ccaacagtgc gccgcaaaac ggccctcacg gtcatcgccg
3743461 ctcagccagc tccacgacac ttgtcagcaa ggacgcccgg ggcgaagggc gttcgccaag
3743521 tctgtagatg agctgcggga gatggccgac ggcgagggtt gagaagcgtc aacttcgatc
3743581 gtgatgcctg ggaggacttc ttatttcata cgcgatcggt gatgccgccc tgaagccgag
3743641 gtcgacggca gcgcggagac gttcgagaag acgtcgcggt gaggtcaatc ccggtgtgac
3743701 caacggccgg ttacggcccg gtgcccgcga acagcaggcc cgacagctgc tggccgacgt
3743761 tcataaagcc cgagacgaag gccgatgtga ccaggccaag cgtgcccgtg ttgtacacgc
3743821 ccgagatgcc cgcgccacgg ttgaggatgc cggagagctg ggtgccgaaa ttggcgaagc
3743881 ccgacgccga cccgagcagc ggatccgaga tcgcgttgag cacccccgac atgcccgacc
3743941 cggagttgga gaagccggac ccgccaccac cgccggtgtt gaagaagccc gacgacggcg
3744001 cggtggtgtc gttgccaaag cccggtgctc cgccgaaccc gaaaatcggg aggctgacgg
3744061 ggccgatggt ggtgctggcg tgtaactcca ccgggatccg gtcgataacg accgtcggga
3744121 gatcaaaggg tggggtgccg ccggacaaac cgaggcccag cgggagttgg ggaatcaggg
3744181 tgccgcccgg gatggtgaag cccggaatgg tcagcgacag cggcaggccg atgtggatgg
3744241 gtccggtggg aatggtgaat ccggggaagt gcagtgtcgt cgggttcaag ttgatgggtg
3744301 ccacggtgaa tggttgaagt atggagacct cgcccccggg catgccgtcg ggtccgaccg
3744361 cgaagaatga aaagctgggt ctgaccttga atccggagct gcttccggac gtcatcctga
3744421 tctccgagac ggcagcatcc aaacttaggc cagggatggt gagggtgatg gggtccacgg
3744481 tgatagggcc gacgtcgaag gtgggatcga tgcccaggtg gatcgagggg atggcgatgt
3744541 tcgggatgct gatcggcccg atgtggccga tcgcggcgaa gcccaacggg atggacggga
3744601 tgtggatggg cggaatgatg gtggcggggc cgatgtcgcc ggtgacgtcg gcgcccaccg
3744661 cggggaacag cggaatgggg tacccgaagg agaagccggc caagccctcg taattgcccc
3744721 gccataagat gccgttgcta aagttgcccg tgatgagggc gccggtgttg acattgcccg
3744781 cgttggcgac gccggtgttg gcgttaccgg tgttgaacca gccggtgttg gtgctgcctg
3744841 ggttgaagcc accggtgttg gtgtcaccag cattgaagct gcccgtgttg tacgacccgg
3744901 cgtttgccac accggtgttg aagccgccgg cgttgaccaa cccggtgctg gccaccccgg
3744961 agttgccgat accggtgttg tagctgccgg agttgaacaa cccgaagttg gcagtcccgg
3745021 agttgaagaa gccgatattg cctgtgccgg agttgaacag gccaatgttg ccagtgccgg
3745081 agttcaagcc gccgatgccg gactggttgt cgccggtgag cccgatcccg aggttgttgg
3745141 tgccggtgtt gccaaacccg atgttgccca ggcccatgtt ggcccagccg acgttgccgc
3745201 tgccggcgtt gcccagcccg atattgccca tgccggccag gcccgccgcc agacccgaat
3745261 tcccgaaccc gaagttggca tcgccgatat tgccgaaccc gacgttgccg ccgccgatgt
3745321 tgccgaagcc caggttcacg tcgccaatgt tgccgaatcc caggttcacg tcgccaatgt
3745381 tggccgcacc caggttgagg ttgccgatgt tgccgaggcc gacgttgccg ttgccgacgt
3745441 tagccaaccc gatgttgacg atggtgatgg ggttttgccc cacgttggag gccaacaagc
3745501 ccgacaggtg atcaccgacg ttgcccaggc ccgacaccaa cgccggcgtc ccaagcggca
3745561 gcgtgctggt gttgtagatc cccgacagcc ccgaaccgag gttgagcacg ccggagtgca
3745621 gtgtgccgac gttggcaata cccgaacccg cgcctgccaa agcggtgtgc gcctggttcc
3745681 accaccccga catgttcgcg ccgaagttgc cgaaacccga gcccccgccc gccccggtgt
3745741 tgaagaagcc cgacgacgga acggtggtgg tgttcccaat gcccggggtg ggcgggatgt
3745801 tgatcagcgg gatgtcgccg gcgatgacgt agagttcgcc gtcggcgttc gccgggatct
3745861 ccgggaacgt gatcgccgga atggtggcgc cgggggtgcc gacgaacaca tccaggttca
3745921 gcagcgagtt cgccgggaac gtcagaccac cggggaacag ggtgatcgcg tcgatgctgc
3745981 ccggcacctg gaaacccaac gggatctggt gaatattgag cgccggggtg ttgaacgcct
3746041 gagatgccgc attgaagacg gcatgcaccg ggccggtcgt gctgagcgtc gggattcccg
3746101 agatgatatt gccgccgacg aacaggtcac cggcgttgta gattctgccg accgagtacc
3746161 acgttgggcc gatcgcaccg gatgacgtcc agacgataaa cggctctatt tcgctggtcg
3746221 ccccgaccga cgcggccata tcgaggaccg ctcgtgcggc ggtcagggcg ggaatggtga
3746281 ccgaggggac cgcgatgggg ccgaagccga cgcttccggt gacgttcgga ttgagggcgg
3746341 gaatatcgat ttgcgggatg gtgaaggcgc ccatcgccgc gttgccggtc aggtgcgcgt
3746401 tgatcgccag aaccgggatg ggcgggacga ccaccgggcc gaaggccccg gtgaaatgcg
3746461 cgtccaggat ggtgatccgg ggaacgtcga ggctgtagga atagctgaat aggccttcgt
3746521 agttgccccg ccacaggatg ccgttgctga agttgcccga catgagggcg ccggtgtcga
3746581 cattgcccga gttcgcgatg ccggtgttgg cgttaccggt gttgaaccag ccggtgttga
3746641 tgctgcccgg gttgaagcca ccggtgttgg tgtcaccgac attgaagctg cccgtgttgt
3746701 acgacccggc gttggccaga cccgtagtga aaccaccggc attgaaaagc ccagtactgc
3746761 ccgttccgct attaccgatg ccggtgttga agctgcccga gttgaacaac ccccagtttc
3746821 cggtcccgga gttgaagaac ccgatgttgc cggtgccgga gttgaacagg ccaatgttgc
3746881 cggcaccgga gttcaagccg ccgatgccgg tctggttgtc gccggtcagc ccaatcccga
3746941 ggttgttggt gccggtgttg gcgaacccga tgttgcccac acccatgttg gccaggccaa
3747001 cgttggtgct gcccgcattg cccaacccga tattgccgat gccgagcgcc gcccccaggc
3747061 ccgaattgcc aaacccgacg ttgccgtggc cgatattgcc gaagccgacg ttggcgttcc
3747121 cgatattgcc caaccctagg ttgaggtcgc cgaggttggc cgcgcccagg ttgaagtccc
3747181 caacgttgcc caacccgagg ttgtagttgc cgacatcggc caacccgagg ttgatgatgg
3747241 ggctttgggt caacgccgtc ccggccgcca acacccccga cagctgctgg cccacgttgc
3747301 cggcacccga caccagcgcc ggcgtcccca aacccacgat agcggtgttg tacagccccg
3747361 atatccccga gccgacgttc agcacacccg agttcagcgt gccaacgttg agaacgcccg
3747421 agcccgcgcc cgccaacgcg gcatgcgcct ggttccacca gcctgagctg ccggccccga
3747481 agttgccgaa acccgacacc ccgcccgcgc cggagttgaa gaaacccgac gacggggtgg
3747541 cggtcgcgtt cccgaagccg ggcgtcggcg gaacgatgat gatcggaacg ctgctgtccg
3747601 gcacgctgat gttgagggcc aggctcagtg gcagcggatc gatcgtgaaa ccacccggga
3747661 atatcgtgat cggatccagc acgccggacg catcgatggt caacgggatc gcattttgcg
3747721 ggatgttgag gccaccgggg aacagcgtga aggccggaag accgcccgac acatcgatct
3747781 tgagcgggat aggcgatgtc gtgatcgttg ggatggtgac ggttgggagg gttagtgcga
3747841 ggctaccggt ggttgcgctg ctgggaccgg tatggatcag gatgccctga gtgggtgcgg
3747901 tgacaaagcc accactcatt ccggttgagt tggacgcccc aacgatccag ttgtcgccga
3747961 gcgcattcac gaacagcaac ggaagtctga agggcggcgg ggcgggggcc gggggcgtgt
3748021 cgagcggaat cgtgtaggtc tgaccgccga tcgtcatgct cggcaggaag acgatgggcg
3748081 ggatgaccat cgtttcgtgg atgtccagca ccactgcggg gacatcgatg ggctcgatcc
3748141 tgaagggccc gatgttgacg agttcgtgga tgtcgaacag cgacatgccg ggaatatcga
3748201 tctgatcgat gtggacggga ccgaggttga gggtttcgtt gatgtccacc agggtgctgc
3748261 cggtgatttc gatgctgtag gagaagccga ccagcccgtg gtgatcaccg gtccacagcg
3748321 cgccgttgtt gaagctgccg gagttgaacg cgccggtgtt gacattgccc gtgttgaagc
3748381 cgccggtgtt ggtgtggccg gcgttgaacc agccggtgtt gacattgcca gggttgaagc
3748441 cgccggtgtt ggtgttgccc gcgttgaggc tgccggtgtt gtaactaccg gcattggcca
3748501 gacccgtgtt gaaactcccg gcattgaaaa gcccggtact gcccgttccg ctgttaccga
3748561 tgccggtgtt gtagctgccc gagttgaaca acccccagtt tccggtcccg gtgttgaaga
3748621 acccgatgtt gccggtgccg gagttgaaca accccaggtt gccggcaccg gagttcaggc
3748681 cgccgaaccc ggtctggttg tcgccggtca gcccgatccc gaggttgttg gtgccggtat
3748741 tgccgaaccc gatgttgccc aggcccatgt tgccgaagcc gacgttgttg ctgccggcgt
3748801 tgcccaaccc gatgttgccg atccccggca gcgcccccag gcccgagttg ccgaacccga
3748861 cattgccgtg gccgaggttg ccgaacccga cgttgccgtc cccgaggttg cccaacccca
3748921 ggttctgccc gccgaggttg ccaccgccga ggttgaggtt gccgaggttg cccgcgccca
3748981 ggttgacgtc gccgacgttg gcgaagccga ggttgtagct gccgacgttg cccaggttga
3749041 cgatgttcag cggattcagg tgccgcagct cggcgatcgc cgcgtcgatg atgctcggct
3749101 gcccggagcc gcccgacccg ccgctggtca gcatcgccag caggccatcg atggacaccc
3749161 ccgacacgtg gttgcccagg ttgccgaaac ccgagatcac cgccggcgcg gagcccagcg
3749221 tgctcacgtt gaacatgccc gagatgtcga cgccggagtt cagcacaccg gatgccaggc
3749281 tgccggcatt gcccaggccg gagagcgtcc ccaccatcgg actcgaggcc tggttcagca
3749341 agccggacac ccccgcgccg aagttggcga tgcccgagcc gccaccgccg ccggtgttga
3749401 agaagcccga cgacggcagc tcggtcgagt tgccaaagcc cggcagcgcc ggaatgtcga
3749461 tgatcgagat gttgatgggt ccggcgctgc tgagaacgtc gaagttcagc ggaatcgggt
3749521 cgatcctggt gccggtgatg gtgaccgccg gaatgtcgac ggacacatcg atcggcacga
3749581 cctccgacat cgaaattccg ttgatagtgg aggccgggat gtcgatcggc ggaatgtcga
3749641 tgggtatgga ttggctgaac gagattgccg gcaattcgat ggcgtcgatg gtctgctgca
3749701 gcggcagggc caatccgccc agcgttgccg aagtaagggg tatggcgacc tgtatctgaa
3749761 ccgagattgt gggatcggga aattcatttg ggaacgcgtc gtggaggaac tgaagcttga
3749821 ggttaacgtt gaacggattg agctggacgt ttgagacggt gatcgggccg aacctgaatt
3749881 gtccggtaat gcccagcgca gaaagcaggg tggtggccgg ggcggtgaag ccggcgtcgg
3749941 cggcaccgtc gaagtcgatg tggattgccg gaatggggat gtccggcacg gcgaagccgt
3750001 agttcgcttg tcccgtgagg cccaggtgga tggggggaag gatcgtggtg tccgggatga
3750061 taatggggcc gatgccgccg gttgaagtcc agtggatcgg gaattcggga atcgtgatgc
3750121 cgacgttcag gccgaacagg ccctcgaagt tgcctcgcca caagatgccg ttgctgaagt
3750181 tgcccgacat gagggcgccg gtgtcgacat tgcccgaatt ggcgacgccg gtgttggcgt
3750241 tgccggtgtt gaaccagccg gtgttgatgc tgcccgggtt gaaaccaccg gtgttggtgt
3750301 cacccacatt gaagctgccc gtgttgtacg acccagggtt ggccacaccg gtattgaaat
3750361 taccggcatt gaaaagccca gtactgcccg ttccgccatt gccgatgccg gtgttgaagc
3750421 tgcccgagtt gaacaacccg aagttcccgg tcccggagtt gaacaacccg acgttgccgg
3750481 tgccggagtt gaacaacccg atgttgccgg caccggagtt caagccgccg atcccagtct
3750541 ggttgtcccc ggtcagccca atcccgaggt tgttggtgcc ggtgttaccg aacccgatgt
3750601 tgcccacacc catgttgccg aagccgacgt tgccgctgcc ggcattgccc aacccgatgt
3750661 tgcccacccc ggccaggccc gccgccagac ccgcattgcc caacccgaag ttggcatcgc
3750721 cgatattgcc gaacccgacg ttgccgccgc cgacattgcc caaacccacg ttcaagtcgc
3750781 cgatattggc cgcacccagg ttgaagtccc cgacgttgcc gaaaccgacg tttacgctgc
3750841 ccacatcggc caacccgaga ttgatgatga ggctctggtt gagtgccgtc cccgccgagg
3750901 acaaccccga cagctgctca ccaacattgc cgatgcccga gaccaccgcc ggggtccccg
3750961 gcggcaaccc gccggtgttg tacagccccg acacacccga gccgaagttc agcacacccg
3751021 atcccagcga accgaaattg gcgaaacccg aacccgcccc agccacctcg gtctgcgcct
3751081 ggttccacca acccgagctg cccgcaccga aattcccgaa gcccgacacc ccaccgtcgc
3751141 cggagttgaa gaaacccgac gacggagcgg tggtcgtgtt gccaaagccc ggggtcgccg
3751201 ggatattaac gccgttgatc aggatagggc cgacagtgac gctggcgccg aggttcagcg
3751261 ggatgcggtc gatcgtgatc ggcggggtgc tgaagccgtc aatctggccg tctatgtcga
3751321 tcgtcagcgg cagcggcgca gcgggaatgg tgaagcccgg gatcgtgaat cccagcgtgc
3751381 cgatcgacgc gctggccagc agcgccagtg gattgttggg aatactgatg ccattcggga
3751441 agatcgttac tgccggggta ctccagttga cggtcaccgg gaatgactgg ttaattctgg
3751501 tgtcgatatt aaggttacct aattggaggg tgacgttgcc ggcaagatct ttgatttcga
3751561 ttcctgaaat gttgacgacc cccaagccaa agaaggggcc gacggggaaa gtcgtgttga
3751621 agttctgagc cgggaacagg gtgatgggcg agatggtgat ggggccgacg ctgataggta
3751681 tggccgtacc gccaccaaaa gcggggatca cgatgtccgg aacgaccagc gggccgaggc
3751741 tgaaggtttg gtgaatgttg agcgggatgg tgggcaaaat ctggatcggc aacacggtga
3751801 tggggccgac gccgccgttg agctcgagac caatggggat cgccggaatg gtcgatccac
3751861 cggagagccc ccacaggccc tcgtagtcac cccgccacag cacaccgttg ctgaagttgc
3751921 ccgagatgaa cgcgccggtg ttgacattgc ccgagttggc gatgccggtg ttggtgttgc
3751981 cggtgttcag ccagccggtg ttgacgttgc ccgggttgaa gccacccgta ttggtgttgc
3752041 ccgcgttgaa gctgcccgtg ttatagctac ccacgttggc cacacccgtg ttgaacccac
3752101 caacgttgaa caacccggta ctggccgtcc ccgcattacc gacaccggtg ttgtagctgc
3752161 ccgagttgaa taccccgaag ttgccggtcc ccgaattgaa gaacccaatg ttgccggtgc
3752221 cggagttgaa caaccccaga ttaccggttc ctgaattcag gcccccaatg ccagtcaggt
3752281 tgtccccggt caacccgatc ccgatgttgt tgctacccgt gttggcaaaa ccgatgttgc
3752341 ccacacccag gtttgcgagg ccgtagttgc tgctgcccgc attgcccaac ccaatattgc
3752401 ccatgcccgg cggcaaccca agacccgagt tgccgaaccc gaagttggcg ttgccgatat
3752461 tgccgaaacc gaaattcccg ctaccggcgt tggcagcacc caaattctgc gcaccgacat
3752521 tggctgcgcc caggttgaat atcccgacat tgcccaaccc gacgttgtaa ttaccgacat
3752581 tgcccaagcc cgcgttaagc ctcaacatct tcgcgggtcc ggcaaataga gcattgagga
3752641 acgcgccgac accacccccc aacgcctgcg ccggtgggct gaacgccggc aacgccgcgg
3752701 cagcagccga cgcgccggaa tggtagccgg ccatcgccgc cacatcggcg gcccacatca
3752761 actcgtactc ggcctcgacg gccgcgatcg ctgcggcgtt ctgccccagc aggttcgaca
3752821 tcgccaacgc ccgcatcgcc atccggttga ccgccaccgc cgccggatcc accgtcgccg
3752881 ccaacgccgc ctcaaacgcc gccaccgcgg cccgcgcctg cccggccacc gccacggcct
3752941 gcgccgccac cgaacccaac caccccgcat acggggccgc cgcggccgcc atcgccgccg
3753001 ccgccgcacc ctgccacacc cccgccgtca ggcccgacgt cacctgccca aacgacaccg
3753061 ccgccgaccc caactcctca gccagcccat cccacgccgc ggccgccgcc agcaacgggc
3753121 tcgaccccgc acccgaatac atcagcacgg agttgatttc cggtggcaga actggaaaat
3753181 tcaaccgccc ctacctctgc cgctcacgat gcgttcacac ctcatcgtct caccacgacg
3753241 tggtgagcgc gggcacttcg acaaactaat ctgcaatatc ccgatcgcgt acaaacgtgc
3753301 cgacatttgc ggcgcattaa tgcccatatc ggcttgtatc tcttgtagtg ccgctttgac
3753361 ggggtggtgg tcaggtacgg tggcctcggg agaggctgga gggctcgacg ttttcggctg
3753421 agtgtctggg cccgtgaaag agatcgtctg ctccagcttt gtctcctgaa ctgacccggt
3753481 ttagggaatt ggtggccagg ttgcggaagt gcgcagcatc gacgtgtacc tgggtgaggc
3753541 atcgaatcat cgacaagcac cggagccgcg cgtgaactcc cgccgcgttg tggtcgggga
3753601 tgatgtggga gaccggccgg cagtgctgtg tacgaaggtt ctcccaccgc aacgagttca
3753661 cgcacgacgg tcggctgggt gggccctgga atacgtgaac tcttcatcaa cacaacatga
3753721 ttgacgatga aggggagaac ctccatgcac aacaacgcta acccgtgact gccgagaatc
3753781 caggacggag caggcggacg ctggtcggaa tcgacgcggc gatcacggcc tgtcaccaca
3753841 tcgcgatccg cgatgatgtc ggtgcgaggt cgattcgatt cagtgtcgaa cccacgctgg
3753901 ccggactgcg caccctcacc gacaagctca gcggttacga cgatatcgac gccaccgtgg
3753961 aaccgacctc gatgacgtgg ctgccgctca cgatcgctgt cgagaatgcc ggtgacacca
3754021 tgcacatggc cggcgcgcgg cattgcgccc ggctgcgggg tgcgatcgtg ggcaagagca
3754081 agtccgacgt catcgacgcc gaggttctca cccgcgccag cgaggtgttc gacctgacgc
3754141 cgctgacact gccgacgccc gcgcagttgg cgttacgtcg atcggtgatc cgacgtgccg
3754201 gcgcagtgat tgacgcgaac cggtcctggc gtcggttgat gtcgttggcg cggtaggcgt
3754261 tccccgatgt gtggaccgcg ttcgccgggt cgttaccgac cgcgacagcg gtgctggggc
3754321 gttggcccga catccgcttg ctggccggcg caccgacccg ccacgttgac cgccgtcatc
3754381 gccgcgcaca cccgcggtgt cgccgacacc ccggcccggc cgaggccatc aagaccgccg
3754441 caaccggctg ggccgcgttc tgggacgggc acctcgacct ggacgcactg gccgtcgatg
3754501 tcaccgagca tctcagcgac ctcaccgacg accgatgcgc gcgttggtga tgccggtgac
3754561 caagaaggtg ttgatcttgg gtgactagtc aatggtggtg gccagggtga gcagttcggg
3754621 gatctgcgag tcgatgcgcc aggcaggaag cggtgtaggt gatggcgcgc caggtggggg
3754681 tccccgccgg tgcgcacggt cgacagcagg gtgcgcagct cctctttggc gatccaggcc
3754741 gagagaatct gcgcgcgggg gtcgacggcg ttgatccgat tccgcatttt ggcgaagctt
3754801 ttgtccgaca agcgttcccg ggcggtcagc aagcgacgtc ggttggccca ctgcgggtcg
3754861 atcttgcggc cgcgccggtc gtggaacgcc caggtcaccc ggcggcgcac cgcggtcagc
3754921 gcgtcgttgg ccagcgtggt cacatggaag tggtcgacga cgagcttggc gttgggcagc
3754981 agcccgggcg tgcggatcgc cgaggcgtag gcagcggcgg ggtcgatggc caccgtactg
3755041 gatgctctcc cggaactgcg gtgtgcgcgc ttgcagccat gccagcaccg ccgcgccgcc
3755101 gcggccttca tgctgcccca taaacccctg atcaccggcc aggtcgacga acccggtatc
3755161 ccacgggtcg acccgtaccc accggccagt cttggcgcag cgctcccatc tgggttttcc
3755221 tcgccgtgtc tggtcaacgc ccagcaccgg ggtgggcaac ggctcggtca atacccgtct
3755281 cggcgtaggc aacaaacgcc cgatgtgccg tcggccacga cacggcgtca gcctgggcga
3755341 cctcggccca ccgagcgggc cgcatccccg atcgccttgg ccatctgccg acgcagccgc
3755401 agcgtgctgc ggacgcgggc aggtacctgg gtgatggcct cggtgaacgg ccccagcttg
3755461 cagtagtctt ctcggcatcg ccagcgaatt ttgttccagc gcaccatgat gcggtcttcg
3755521 ccataaggta gatctttcgg tgaggtaacc gcgtattcct tcactgatat cgagaccacc
3755581 cccgcacgac gggcacgccg ccgccgtcgg ctcatcggtg atcacatcga ccacccgggt
3755641 cccgtcactg cggcgctcga cacgctcaac ccgtgctcct ggcagcccga acaacactgt
3755701 cgtagcgtca gacacagccc ttggctcctt cctcggcctg aatgcttcgc aacacttaga
3755761 cttcagaagg ccaagggccc tcagccgcta aacacgccga ccaagatcaa cgagctacct
3755821 gcccggtcaa ggttgaagag cccccatatc agcaagggcc cggtgtcggc gcaaaattta
3755881 gcgtcgttgc gcccacacca gagttaccgc cgcacacacg gcgtgaccac cggcgtgcat
3755941 ttaagaatcc gttagggccc gacgccggtg aagagcaagc ccgacagttg ctggccgacg
3756001 ttgccgaaac ccgagacgac ggccgcggtg acaacaccca gcgcgccggt gttgtacacg
3756061 cccgagatgc cggcgccgcg gttgaggatg ccggagagct gggtgccgaa gttggcgaag
3756121 cccgacgccg acccgagcag cggatccgac atcgcgttga gcaatcccga catgcccgcg
3756181 ccggtgttgc taaagcccga accgccgcca gctccggtgt tgaagaagcc cgacgacggc
3756241 agcgtggtcg agttcccgaa acccggcgcc ccgccgaacc cggcgatcgg gacgttgatc
3756301 gggccgatag tggtgtcggc gtgcaggtcc agcaagatcc ggtcgagaac gatggccggg
3756361 atgtcgacgg gcgggatgcc attggacaac gcgaggccca gcgggagggt ggggatcagg
3756421 gtgccgcccg ggatggtgaa ccccgggatg gtcagcgaca ccggcaggcc gatgtcgatc
3756481 gggtcgaggg ggatggtgaa tcccgggaag gtcaccgtgc cggaggggat ggagatgggc
3756541 cccacaaagt atgccccttg cgtggacgtt gcacccccgc cgctagaggg cgcgatccgg
3756601 attccgggga agaagctggg cttgacccaa atctctgagg ttggtccgga cgtgctggtg
3756661 acggctcctt gggagtaact gacgagcacg ggcggggtcc tgacggtaat ggggttgacg
3756721 gtgatggagc cgacatggac ggcggggtcg aggcccaagt gaatggatgg aacagagatg
3756781 tccgggatgg cgatcgggcc gatgccaccg accgcggcga agccgaccgg aatgggcggg
3756841 atgtggatgg gcggcagcac ggtaatcggg ccgatcccgc cgctgacgtc ggcgcccacc
3756901 gcggggaaca gcgggagggt gtagcccacg gcgaagccgg ccaggccctg gtagtcgccg
3756961 cgccacagga tgccgttgct gaagttgccg gtgacgaagg cgccggtgtt gacattgccc
3757021 gcgttggcca ccccggtgtt ggcgttgccg gcgttgagcc agccggtgtt gatgctgccc
3757081 gggttgaagc ccccggtgtt ggtgtcaccg acattgaagc tgcccgtgtt gtagctgccg
3757141 gcgttggcca caccggtgtt gaaactgccg gcattgaaga gcccagtgct gcccgttccg
3757201 ctattgccga cgccggtgtt gaagctgccg gagttgaaca acccgaagtt gccggtcccg
3757261 gtgttgaaga acccgacgtt gccggcgccg gagttgaaca accccaggtt gccggcaccg
3757321 gaatttaggc cgccgatgcc ggtctggtag tcgccggtca gcccgatccc aatgttgccg
3757381 gtgccggtgt tggccaaccc gatattgccc acgcccacgt tggccaaccc ccagttgttg
3757441 ccgccggcat tgcccaaccc cacattgccc aggcccggca cgcccgcggt cagacccgag
3757501 ttgccgactc cgacattgcc gtggccaata ttgccgaacc ccaggttgcc ggcgccgata
3757561 tttccgaagc ccaggttgtg cgcgccgagg ttggccgcgc ccaggttgac ctccccgaca
3757621 ttgccgaaac cggcgttgtg gctgccgacg ttggccaacc cgatattcag aacggtcacc
3757681 gggttcaccg cggacccgcc ggaaagcagc cccgacagtt ggtggccgac gttgcccagg
3757741 cctgagacca gcgccggggt ccccaccccc agcgtgctgg tgttgtagat ccccgagaca
3757801 cccgagccca ggttgagcac accggaatgc agcgtgccaa cgttggcaaa acccgagccc
3757861 gcccccgcca gcgcggtgtg cgcctggttc caccagcccg aggtgcccgc gccgaagttg
3757921 ccgaagcccg atcccccgcc cgcgccggcg ttgaagaagc ccgacgacgg ggtgatggtg
3757981 ctgttcccaa tgcccggggt gggcgggatg ttgatcagcg ggatgctgct ggcgaggaca
3758041 tacaccgagc cgtcggcgct cgccgcgatc tcgggccagg tgatggccgg gatgtccacg
3758101 ccgccggcgc cggcggtcac gtccaggttc agcagcgagg tcgccgggaa cgtcaaacca
3758161 ccggggaaga gggtgatcgc gttgacgctg ccgggcacct ggaagcccaa cgtgatcggg
3758221 ccagtttcga gctgcggagt ggtaaacgcc ccgctggacg cggaaatggt gagatggctt
3758281 ccgtcgctcg tgccggcgcc gaaaacgagt gggccggtgg cgtagggcga accgtcggcc
3758341 gatccgaatg aatagaaggt tataccaagg ccattagtgc cttgagtcca catttcgaag
3758401 ggatctatcc tcatctccgc cccaaccgag gcgttgatta tttgctccac aatgacactc
3758461 accggcggaa tgcgcacgga ccccacaacg atgcggaagg cggcgcttcc ggtgatgttt
3758521 ggggtgagtg cggggatgtc gatctgcgga atggtgaatg cgcccatcgc gacgtttccg
3758581 gtcaggtgcg cattaacggc cggcaccggg atgggcggga ggaccacggg tccgaagccg
3758641 ccgtcgaggt gggcgtccac gatggtgatc cggggcacgt cgaggctgta gaacaggctg
3758701 aacaggccct cgtgatcacc ccgccacaac aggccgttgc tgaagttgcc cgacatgaac
3758761 gcgccggtgc cgacgttgcc cgagttggcg atgccggtat tggtgtggcc ggtgttgaac
3758821 cagccggtgt tgatggtgcc cgggttgaac cccccggtgt tggtgtcgcc ggcattgaag
3758881 ctgccggtgt tgtagctgcc ggcgttggcc acgccggtgt tgaagctgcc ggcattgaag
3758941 agcccagtgc tgcccgttcc gctattgccg atgccggtgt tgaagctgcc cgagttaccg
3759001 atgccgaagt tgccggtccc ggagttgaag aacccgatgt tgccggtgcc ggagttgaac
3759061 aagccgatat tgccggcacc ggagttcagg cccccgatgc cggtgaggtt gtcccccacc
3759121 agcccgatcc cgatgttgcc ggtgccggtg ttggccaacc cgatgttgcg cacgccctgg
3759181 ttggcgaaac catagttggc gctgccggca ttgccgaacc ccgtgttgcc caggccggcc
3759241 gcgccggcgg tcagacccga attgccgaaa ccgatattgc cgtggccgac gttggcgaag
3759301 ccgaggttgc cggtgccgac gttgcccagc cccaggtttt gcgcaccgag gttggccgcg
3759361 cccaggttaa cgtccccgac gttgccgaac ccgacgttga agttgcccac atccgccaac
3759421 ccgatgttga ggatggggat ctggttcaac gcggtcccgg ccgcagacac gcccgacagc
3759481 tgatggccga cgttgccgag gcccgacagc accgccggcg tcccgagcgg caacacgctg
3759541 gtgttgtaga tccccgagac acccgagccg acgttgagca cacccgagcc cagcgtgccg
3759601 acattcaaca cccccgatcc cgaccccgcc agcgcgctcg ccgcctggtt ccaccagccc
3759661 gacaggttcg acccgacgtt tccgaacccc gacaccccac cggcgccgga gttgaagaac
3759721 cccgacgacg gggtcgccgt ggtgttgccg aaccctggcg tcggcgggac atcgatgatc
3759781 gggatgctgc tgtcgggcac ggtgagattc agcgccaggt gcagcggcag cgggtcgatc
3759841 gtgtacccac ccgggaaaat cgtgatcgga tccagcgcgc cggacgcatc gatcgttaac
3759901 gggatggcgt tcgtggggat cgtcaggcca cccgcgaaca aggtgaaggc cggcagacca
3759961 ccgctgatgt tcacgtccaa caggaatctc gtggtagcga tttgcggaat ctcgaaaccc
3760021 ggaatagata tcttgagctc gccggtcgtt ccggggccag ggccggtgtg aatggtgatg
3760081 ccctgggtgg gcgccgggaa ggggtctccg aaattgggaa tcgccgcggt cgacccgagg
3760141 atccagtcct cgccttcgaa gcgcatgctg atgagcggaa gcgtcatggt tgacccgggt
3760201 gaggcgggga tgtccagcgg aatggttctc gtctgtgcgg gaattgtggt ggcgggcacc
3760261 aggacgatgg gatccatgtg gatcgattcg tggatctcta gcggtatcgc gggaacatcg
3760321 acctgcggga tggtgaaggg tccgatctcg acgatttcgt ggacgtcgaa cagcgacatg
3760381 ccggggatgt cgatctgctc gatgtggatg gggcccaggt tgagggtttc gttgaggtcc
3760441 agcagggtgc tgccggcgat gtcgatgctg aaggagaagc cgaccagccc gtggtagtca
3760501 ccggtccaca gcgccccgtt gttgaagctg ccggagttga acgcgccggt gttgacgttg
3760561 ccggtgttga acaggccggt gttggtgtgg ccggtgttga accagccggt gttgacggtg
3760621 cccgggttga cgccgccggt gttgaagctg cccacgttga ggctgccggt gttgtaggag
3760681 ccggcattgg ccagaccggt gttgaagttc cccgcgttga acaacccggt gctggccgtg
3760741 cccgcattcc ccacaccggt gctgtaactg cccgagttga acagcccgaa gttcccggtc
3760801 ccggtgttga agaacccgat gttgccggtg cccgagttga acaacccgag gttcccggtg
3760861 cccgagttca ggccgccgat cccggtccga tagtccccgg tcagcccgat cccgatgttg
3760921 ccggtgccgg tgttggccaa cccgatattg cccacaccca cgttggccaa cccccagctg
3760981 ccgctgccgg cgttacccaa ccccacattg cccaggcccc ccgcgcccgc ggtcaggccc
3761041 gcgttgccga atccgaaatt gccggcaccg atgttgccga acccgaggtt gccggtcccg
3761101 acgttgccca accccaagtt gctgccgccg aggttgccgg cgccgacgtt gatgttgccg
3761161 acgttgcccg cacccaggtt gaactcaccg acgttagcca aaccgaggtt caccccgccg
3761221 acattgccca aggccaaagc gttgccgatg tcgaggtgct gcagctcggc gatggccgcg
3761281 tcgatgatct gatcgaacac ggactcggca ggtgggaagg tgaggatcgc gatcaggcca
3761341 tcgatggaca cccccgacat atggtcgccg aggttgctga accccgagat caccgccggg
3761401 gtggtggcgt ccagcgtgct cacgttgaac agcccggaga tggcggtgcc ggagttcagc
3761461 acacccgagg ccagggtgcc ggcattgccc agccccgaga gtgtccccac cagtgacccc
3761521 gcgccggcct ggttgagcag gcccgacacg cccgcaccca agttgccgat gcccgatccg
3761581 ccgccggcac cggtgttgaa gaaccccgac gacggcatct gggtcgagtt cccgaagccc
3761641 ggcgccgccg ggatgtcgat gatcgggatg ttgaggggtc cggcactggt gcgaatgtcg
3761701 aagcccagcg ggatcgcgga aatggtggtg cctgtgatcg tgaccgccgg gatgtccacg
3761761 gacgcatcga tcggcaccac ttccgacatt gaaatcccat cgatgaccga ggccggaata
3761821 tcaacaggta tgcggatagg aatcgactca ctcaacgaaa tcgcatccag ggggatgggc
3761881 tcgatctcca ggggcacacc gatcccggcc accacgattg gctcaagatg aattggtccg
3761941 agttggcccg tgataggacc aagaacgggc aggcctaacg tgaaatccat gggcggaata
3762001 tcgatattcg agagcgtgat ggggccgaag ctgatgaagc taccgttatt cttcagggcg
3762061 gacagcaggg tggcttccgg ggcggtgaag ccgacggtga cgacgccatt gatgccgatg
3762121 tggatggcgg ggatggggat gtcgggcacg gtgaagctgt agtccgcgtc gccggtgatc
3762181 tgcaggtgca gcggcggaag gatcgtggtg tccgggatga cgatggggcc gataccgcca
3762241 gtcgtggtga tgcggatcgg gaattgcggg atcgtgatgc cataggacag gccgaacagg
3762301 ccctcgtggt cgccgcgcca cagcatgccg ttgctgtcgg tccccgacat gagggcgccg
3762361 gtgttgcggg tgcccgtatt cataatgccg gtgttgaacc agccggtgtt gatgtcgccc
3762421 gggttgaaac caccggtgtt ggtatcaccg acattgaagc tgcccgtgtt gtacgacccg
3762481 gggttggcga tgccggtgtt gaaattgccg gcattgaaga gcccagtact gccggttccg
3762541 ctattaccga tgccggtgtt gaaactaccg gagttgaaca gtccgaagtt gccggtgccg
3762601 gtgttgaaga acccgacatt gccggtgccg gaattgaaca atccgatatt gccactaccc
3762661 gagttgaggc cgccgatgcc ggtctggtag tcgccgacca gcccgatccc gatgttgccc
3762721 gtgccggtgt tggccaaccc gatgttgccc acacccaggt tggccagccc ccagttgttg
3762781 ctgccggcat tgctcaaccc cacgttgccc aggccggcca ggcccaccgc cggacccgag
3762841 ttggcgaacc cgacgttgcc ggcaccgatg ttgccgaacc cgacgttccc gctgccgaga
3762901 ttgcccaggc ccaggttctg cgcgccgatg ttggccgcac cccagttgag gtcccccaca
3762961 ttgcccaacc cggtgttgaa cgcgcccaca tcggcccacc cgatattgac aatggggctc
3763021 cggttgagca cggtcccatt tgccaagaac cccgacagct gctggccgag gttgccgatg
3763081 cccgagacca ccgccggggt gcccgctccc agggtgctgg tgttgtacca cccggagatc
3763141 cccgagccga cgttcagcac gcccgagctc agcgtgccgg cattggcaac tcccgagccc
3763201 gcccctgcta acacgtcgtg cccctggttc caccagcccg acgtgcccgc gccgacgttg
3763261 gcgaaccccg atccaccgcc gccgccggtg ttgaagaacc ccgacgatgg ggccgtggtg
3763321 gtgttgccga accccggcac cgccggcaca tcgatgatcg ggatcgggat atcgccgatg
3763381 aggatggtgc cgtcgaaggt cgccggcacg gtgtcgaggg tgaacccgtc gggcaacagc
3763441 gtgaacgcgt ccagccccac ggacagtccg gtgaccccgg cggaggcccg cggaaaggtc
3763501 agcccacccg ggaagaaggt gaacccgtcg ttggcgacct ccatacccac cgtcacgggg
3763561 gtttgcgcgg gaatggtgaa accattcggg aaaagcgtcc acggggtggt gtccaagttg
3763621 agggttaggg gaattggtgt cggggtgacc aatatctgac cgctaaccgt gaggccgggc
3763681 acaatgatgt tctctaggaa caagacaccg gcaacaactt ggaacgcatc aatggtgata
3763741 aatgggtcac tgaggcggaa cggctcgaga aaaagcccta tcgaaccggc gagcgggtca
3763801 agagcgcgaa tcggcgagat ggtgtttgcg gccaggtcca cgcttccggt gatgctggcg
3763861 atgggaagtg agggaatgct gatcggtggg acggtgaacg gacccaggcc gacggtggcg
3763921 tcggtgatct cgacgtgcac ggcgggtacc gggacgggcg ccacatgcag cgggcccacc
3763981 ccgccgatcg cgtgcacggt gaccgggaat tgggagatcg tgggcccgac gcggacgccg
3764041 accaggccct cgtagccgcc ccgccacaac aggccgttgc tgtagtcgcc cgtcatgaag
3764101 gcgccggtgc cgaaggtgcc cgcgttggcc aacccggtgt tggcatgccc ggtgttgaac
3764161 cagccggtgt tgatgccgcc cgggttgaag ccaccggtgt tggtgtcgcc ggcgttgaag
3764221 ctgcccgtgt tgtagtcacc agtgttggcg atgccggtgc tgaagctgcc ggcattgaag
3764281 agcccggtgc tggccgttcc gctattaccg atcccggtgt tgaagcggcc ggagttcccg
3764341 atgccgaagt tgccggtccc ggaattgaag aacccgacgt tgccggtgcc ggagttgaac
3764401 aacccgatat tgccgatgcc ggagttcaag cccccgatcc cggtccgatg gtccccgacc
3764461 agcccgatcc cgatgttgcc cgtgccggtg ttggcaaacc caatattgcc cacacccatg
3764521 ttcgccaagc catagttgtt gatgccggca ttgccaaaac caacattgcc cacccccgcc
3764581 gcgccggcgg tcaggcccaa gttggcaaac cccaggttgc catggccgat gttgcccaac
3764641 cccaggttgc cgtccccgac attgcccagg cccaggttgt gcccaccgat gttggccgca
3764701 cccaggttga cgtccccgac atttccgaac ccggtgttga agttgcccac attggccaac
3764761 ccgaggttgc cggcgagcat cgagcgcagc gtggttcccg ccgccgacac ccccgacagc
3764821 tgctggccca ggttgccgat gcccgacacc gccgccggtg tcccgaaagg caacacgctg
3764881 gtgttgtaga accccgagat ccctgagccc aggttgagca cacccgagcc cagggtgccc
3764941 acgttgccaa cacccgaacc ggcccccaac agcgcgctcg gcgcctggtt ccaccagccc
3765001 gagctgcccg cgccgacgtt gccgaaaccc gacaccccac ccgcaccgga gttgaagaat
3765061 cccgacgacg gggccgtggt ggtgttcccc actcccggcg ccgccgggat atgaaggccc
3765121 tggatcgtga tggggccgat cgtgaccccg ccccccacgg tcagggggat gcgatcgatc
3765181 gtgatcggcg gggtgctgaa cccgtcgatc tggccctcga tatcgatcga caacggcaac
3765241 ggctgcgcgg gaacactaaa tcccgggatg gtaaagcccg ggttactgat cgacacactc
3765301 accagcaacc ccaaaggatt atcgggagca ctgatgccat tcgggaacag cgtgatcgga
3765361 ggggtatccc atctgatcgt taaatcaatc tgtggattgg tgggtccggg aatggtggtg
3765421 tcgataacga tagggccgat aaagctgaca agctgaccgt tagaatcaaa ggtttggatt
3765481 tgtggaattg tgattttccc taaactgaag gtgggaaagg gcaattggtt gacaaatgtc
3765541 tgttgggcaa acagggtgat gggtgtgatg gtcagcgggc cgatgttgat gggtatgccg
3765601 ataccgccgc cgaaggcggg gatcacgatg tcgggaacca ccagcgggcc caagttgacg
3765661 gtttggtgaa tgctgagcgg gatggtgggc aggatcggga tgggctggat ggtgatcggg
3765721 ccgatgtcgc cgttgagcac caggccgatg ggaattgcgg ggatcgacga gccggcggag
3765781 acgccgaaca ggccctggta gtcacccacc cacagcacgc cgttgttgaa gttgcccgag
3765841 atgaacgcgc cggtgttgac gttgcccgag ttggcgatgc cggtgttggt gttgccggtg
3765901 ttcagccagc cggtgttcac accgccgggg ttgaagccac cggtgttggt gtcgccggcg
3765961 ttgaaactgc cggtgttgta actgcccacg ttcaccacgc cggtgttgaa attgccggca
3766021 ttgaacaacc ccgtgctggc cgtccccgca ttaccgacac cggtgttgta attacccgag
3766081 ttgaacaccc cgaagttccc ggtccccgaa ttgaagaacc ccacattccc ggtgccggag
3766141 ttgaacaacc cgatattccc ggtgcccgaa ttcaggcccc cgatacccgt caggtggttg
3766201 ccggtgagcc cgacgccgac gttgttggtg ccggtgttgc cgaaaccgat gttgcccaca
3766261 cccaggtttg cgaaaccata gttgctgctg cccgcattgc ccaacccgat attgcccaag
3766321 ccggccaggc ccgcccccag accggagttg ccgaacccga cattcccgtt accgaggttg
3766381 ccgaacccga cattggtgcc accggcattc ccgaaaccca gattctgccc acccacattg
3766441 cccgcgccca ggttgaacac cccgacattg cccaacccga cgttgtaatt gccgacattg
3766501 cccaaacccg cattcaggct cagcgccttc gcagggctgg cgaacagggc ggtaaggaac
3766561 gcgccgacac ctccccccag cgcctgcgcc ggtgggctga acgccggcaa cgccgcggca
3766621 gcagccgacg cgccggaatg gtagccggcc atcgccgcca catcggcggc ccacatcagc
3766681 tcgtactcgg cctcggcggc cgcgatcgcc ggcgtgttct gccccaacag attcgacacc
3766741 gccaacgcca ccagccgcgc ccggttggcc gccaccagcg ccggatccac cgtcgccgcc
3766801 aacgccgcct caaagacccc caccaccacc cgcgcctgcc cggccaccgc ctcggccgcg
3766861 gccgccaccg aacccaacca ccccgcatac ggcgccgccg cggccgccat cgccgccgcc
3766921 gccgcaccct gccacacccc cgccgtcagg cccgacgtca cctgcccaaa cgacaccgcc
3766981 gccgacccca actcctcagc cagcccatcc cacgccgcgg ccgccgccag caacgggctc
3767041 gaccccgcac ccgaatacat cagcacggag ttgatttccg gtggcaacac cggaaactcc
3767101 atcacccatt ccccttccca gcccgacacc aatccccacc gacacccccc acatgacgtg
3767161 tcgacgcccc gataattttg ctcgcattgc caacggccca agaacgattc cccgataatc
3767221 gcgggtactg ggtgcacttt gcacagacgc cgcagcaaaa tgcacatatg ccctgtccag
3767281 accggcgagc ggcagggcgt catctgccct gacacttcga ctgctggcgg agtccgcgag
3767341 catgctcacc gccgcggcgt gcgccgaacc ggcagcgccg gcaaatccat gaccccagcc
3767401 tgttcttggg tcactgcgac gttcactttt aagcgcgacc acgtaaggtt gggcaaagtt
3767461 cccaagcgtt tcacagtgtc agtgcacagt gcgcacctga ttaccaaaac cccgaacctc
3767521 actcgaaagc cgagagcggg taaaagtcgt tcagcgacct gtctggtaga gaaatccaga
3767581 cccgagtaca tgatccggtc gggatcgtac ttgcgccgca ctgtggtcag ccgcgacagg
3767641 ttcgcgccga agtattgtga cgccgcggcg ttggcctcca ggtagttgac atagccgccg
3767701 accgaaaagt gttgcaccgc gtggtgtgcg tcgctcagcc atttgttggc cgtcgccacc
3767761 tggccgtcgc tgggggtgtt gacataccac tgcaccacag cggactggcg gcaccaggga
3767821 aatgccgagc cctccgggtc catgtcgccc accgcgccgc ccagcgaatc gatcagagcc
3767881 gacgcgcggc ccgcagcggg tggccatgtt ccgatggcgg cgacgatggc ttgggccgcg
3767941 gccggattcg tcgtcccgat gacatcggat ccagccacga agccctccgg cggataggtc
3768001 gtatggccgc cggccagata cctcaccagg tccatacggc gcagcgtctt gtgctcaact
3768061 ccactgggtt gcactccaac cgcggacttg atcgcatccg cgacagccgc gccggaccgc
3768121 gccgggcagc tcgccagcac atgacaattg cctccggatg agctgaccgc ggggtcaacc
3768181 agaccccacg tggtgcggtc ggccccggcc agccacgtct gtcagccgac cagcacctgc
3768241 gcggccgcag acggcgcgaa atcgacacgg acgacatcgc agtccgcggt ggggaacctc
3768301 gcgaacgtca tcgatgtcgt caccccgaag ttgccgcccc cgccgccacg aagcgcccag
3768361 aacagctccg cgtggtcgtc ggcagacgcg ctcaccgcat caccgccggg caacaccacc
3768421 gtcgccgact tgagcgcatc gcaggtcaac cccgcatggc gagaatcggc gcctaacccg
3768481 ccgcccaggg tcaaacccgc cacacccacg gtcgggcagc tgccggtcgg aatcgcccgg
3768541 ctctcaccgg ccaacgcttg atggaccgca tagagatcgg tcgcggccga caccgtacgt
3768601 ttctcgtggc gctgtcgaaa tgcaccccgc ccggtaggcc cagcagatcg agcaccatgg
3768661 cgccattggc cgacgaggcg ccgatgtagg aatgtccgcc gccgcgcaca gcgatcttga
3768721 gcttgctggc cgccgctacg aaaccgcctt ccggacgtct gcctgcgagg cgaccgtcac
3768781 caccgcggcc ggattcaagc cgctgtagtt cgaattgaag atctgctttc cgctcgtgaa
3768841 cgccctgccg ttggccggca gcagcacctg cccgcctatc gatgaggcca gactggccca
3768901 cccatcaccc ggtgttgcgc gcgccaatat cgtcgggaag accgccgacg tcgccggcgc
3768961 tccgacggcg ccgcgaagaa acgtctggcg agacatcacg accgcgatcg tgtcgtatcg
3769021 agaaccccgg ccggtatcag aacgcgccag agcgcaaacc tttataactt cgtgtcccaa
3769081 atgtgacgac catggaccaa ggttcctgag atgaacctac ggcgccatca gaccctgacg
3769141 ctgcgactgc tggcggcatc cgcgggcatt ctcagcgccg cggccttcgc cgcgccagca
3769201 caggcaaacc ccgtcgacga cgcgttcatc gccgcgctga acaatgccgg cgtcaactac
3769261 ggcgatccgg tcgacgccaa agcgctgggt cagtccgtct gcccgatcct ggccgagccc
3769321 ggcgggtcgt ttaacaccgc ggtagccagc gttgtggcgc gcgcccaagg catgtcccag
3769381 gacatggcgc aaaccttcac cagtatcgcg atttcgatgt actgcccctc ggtgatggca
3769441 gacgtcgcca gcggcaacct gccggccctg ccagacatgc cggggctgcc cgggtcctag
3769501 gcgtgcgcgg ctcctagccg gtccctaacg gatcgatcgt ggatgcgatg tagaccatgg
3769561 ccgccgcgac cgtcacggtc gtcacgaaat cgatcccctt gctgcgcacc accaacaggc
3769621 cggcccgttc ctcggacaac accaaccgca gcaccgccgc caccccaacg ccgataccga
3769681 tcagcagcgc accacggcgc cagaagttag cccccgccag cacgaacccc accgcgaaga
3769741 tcgacccaac cagcaggatc ggccactggg cgccaacagt gcgccggaaa acggccctca
3769801 cggtcatcgc cgctcagcca gctccacgac attggtcaac aagaacgccc gggtcaacgg
3769861 gcccacgccg cccggattgg gtgacacgtg gccggcgagc tcccacacat cgggatgcac
3769921 gtcgccgacc agtccgtcat cagtgcggct gacgccgacg tcgattaccg cggcacccgg
3769981 gcgcaccatg tcagccgtca acaggtgcgc caccccgacc gcggccacga cgatgtcggc
3770041 ctgccgggtc aacgcgggca ggtcgcgggt accggtgtgg cacaacgtca ccgtggcatt
3770101 ctccgagcgc cgggtcagca acagccccag cggccggccc accgtcacac cacgaccgat
3770161 aacgaccaca tgcgcgccgg cgatcgagat gtcgtagcgc cgcagcaggt gcacaatgcc
3770221 gcgcggagta cacggcagcg gcgccggggt gcccagcacc agccggccca ggttggtcgg
3770281 gtgcaaccca tcggcgtcct tggccgggtc gacgcgctcc aacgccgcgt tctcgtcgag
3770341 atgcttgggc aacggcaact gcacgatgta gccggtgcag tcggggttgg cgttcagttc
3770401 gtcgatggtc tcattcagcg tggcggtgct gatgtcggcg ggcaggtcgc ggcgaatcga
3770461 cgtgatgccc accttggcgc aatcagcgtg cttaccgcgc acgtaggcct gcgaccccgg
3770521 gtcgtcaccg accaggatgg tgcccaagcc gggcgtgcgg cccgccgcgt ccaatgcggc
3770581 cacccgctgc ttgaggtcac cgaagatctc gtcgcgggta gccttgccgt ccagcatgat
3770641 cgcgcccacg ccagccagtc tggcatgcgt gtccgcggtg ccgatggcga cgacccgctc
3770701 acgcgcccac cgtacggaca acttgtacca ttgtggtaca gattatccgt acatctttct
3770761 aagagaggac gcatgagcat cagtgcgagc gaggcgaggc agcgcctgtt tccactcatc
3770821 gaacaggtca ataccgatca ccagccggtg cggatcacct cccgggccgg cgatgcggtg
3770881 ctgatgtccg ccgacgacta cgacgcgtgg caggaaacgg tctatctgct gcgctcaccg
3770941 gagaacgcca ggcggttgat ggaagcggtt gcccgggata aggctgggca ctcggctttc
3771001 accaagtctg tagatgagct gcgggagatg gccggcggcg aggagtgaga agcgtcaact
3771061 tcgatcccga tgcctgggag gacttcttgt tctggctggc cgctgatcgc aaaacggccc
3771121 gtcggatcac ccggttgatc ggagaaattc agcgtgatcc gttcagcggg atcggcaaac
3771181 ccgagccgct ccaaggtgag ttgtcgggat actggtcgcg ccggatcgac gacgaacacc
3771241 ggctggtgta tcgagcgggc gacgacgaag tcacgatgct gaaggcccga taccactact
3771301 gatttggggg ctggtggtat tccggcgggc ttaagctccc catgtggctc ccggcagctg
3771361 cgaagccccg gacgtgttca acccggccaa actcggtccg ctcacgctgc gtaaccgggt
3771421 catcaaggcc gccaccttcg aggcccgcac acctgacgcg ttggtgaccg atgacctgat
3771481 cgagtaccac cggctgccgg ccgcgggcgg ggtcgccatg accaccgtcg cctattgcgc
3771541 ggtctccccc ggcggacgca ccggcggcaa ccagatctgg atgcgcccgc atgcggtgcc
3771601 gggactgcgc cggctcaccg aggcgataca cgccgagggg gcggcgatca gcgcccagat
3771661 cggccacgcc ggcccggtgg ccgacgcccg ctccaaccag gcgaccgcgc tggctccggt
3771721 gcggttcttc aatccgatcg ctatgcggtt cgcccagaag gcgacccgcg aggacatcga
3771781 cgatgtgctg gccgcgcacg cccatgccgc ccggctggcc gtcgacgccg gcttcgacgc
3771841 cgtcgaaatc catttggggc ataactatct ggcgagcgcg tttctgtctc cgctgctcaa
3771901 ccggcgtgat gacgagttcg gcggttcgtt gcagaaccgg gcgaaggtag ctcgcggatt
3771961 ggtgatggcc gtgcgccgcg ccgtccggca gcaggtcgcg gtgaccgcca agctcaacat
3772021 gaccgatggc atccgcggcg gcatcacagt cgacgaggca ctgaccaccg ccaggtggct
3772081 gcaggacgac ggcgggctag acgcgatcga gctcaccgcg ggcagctcgc tggtcaaccc
3772141 gatgtatttg ttccgcggcg acgcgccggt taaggagttc gccgccgcgt tcaaaccacc
3772201 gctgcgctgg ggcatccgga tgaccggcca taggtttttc cgcgaatacc cctaccgcga
3772261 tgcctatctg ttacgcgagg ctcggttgtt tcgcgccgag ctgacaatcc cgctgattct
3772321 gctgggcggc atcaccaacc gaacgaccat ggacctggcg atggccgaag ggttcgagtt
3772381 cgtcgcgatg gctcgggcgc tgctcgccga gcccgacctg gtcaatcgga tcgcggccga
3772441 aggcagccag gtgcggtcgg cgtgcacaca ctgtaatcag tgcatggcca cgatttatcg
3772501 ccgcactcac tgtgtggtca ccggggctcc atagcgtcca gattgacgcc accgtgaaga
3772561 agtgcaaccc attgtgccgg aaatccggtt gacttccccg cgcgaatccg gctcaggcac
3772621 tattgaccgc gcgcagcata atttgaaccg atgagtcgac cccatccacc ggtgctgaca
3772681 gttcggtccg atcggtcgca gcaatgcttc gccgcgggcc gcgacgtggt tgtcgggagt
3772741 gatcttcgtg ccgacatgcg cgtggcgcac ccactgatcg cccgtgcgca cctgttgctg
3772801 cgcttcgatc ggggcaattg gatcgcgatc gacaacgatt cgcagagcgg gatgttcgtc
3772861 gacggccagc gggtgtcgga agtcgacatt tatgacggcc tgactatcaa catcgggaag
3772921 cccaccgggc cgtggatcac cttcgaggtc ggccatcacc agggcatcat cggacggctg
3772981 tcacgcaccc cgtcgtcgcg tcccggctca ccgatctagc cccctgccaa gcacagcccg
3773041 tgcgccgccg caaaggccac ggcttggtcg acgtcgacac gcgcacccac caacgacgcg
3773101 gtccgccaca ataccgggtc cacggtcgcg ccccgcaagt cggcgtcatc cagccgggcg
3773161 cccgtggtac gggcaccact gaggtcggcg ccgcgcagca cgcacttgcg caagtcggta
3773221 tccaccaggc tggtctctcg caaccggcag ccggtcaagt tgagaccacg cagatcattt
3773281 ccgccgagca cggcgagcgt gaaatccacg tcgtccaacg tcagcggccg cagccggcaa
3773341 gccacgaaga ccgagcccaa catgctgcac tgggcaaatg tgctgtgcca cagtgtcgtc
3773401 cgttcgaagg tgcaattacg aaacgccgac cctcggtgtt gtgactcggc cagattcacg
3773461 ccgctgaaat cgcattcgct gaacatcgcc cgttcggtgt gcaggcggct aaggtcctcg
3773521 tcgcggaagt ctcgaccggt gaattcgcaa tcaacccact gctgcaacgc ttttcaaccg
3773581 cccgcaggag acagggtggc cagcgcgtat tcgctcaccg cgatcagtgc atcggtcgcc
3773641 gacctgcgat tgcgggcgtc aacattgatc accggaatgt gtgcgggcag cgtcaacgcg
3773701 tcgcgcaccg cgctaaccgg ataccttggc gcgctgtcga actcgttgat ggcgatcaag
3773761 aacggcaggt tgcggtgttc gaagaagtcg accgccgcaa agctgtcctg cagacgccgg
3773821 cagtcgacca agacgatcgc cccgatggca ccacgcacca ggtcgtccca catgaaccag
3773881 aaccggcgct ggcccggggt accgaataga taaagcacca gatcctcgcc caaggtgatg
3773941 cggccgaagt ccatcgccac cgtggtgctc cgcttgtcgg gagtggcctc cagcatgtcg
3774001 acgccggcgg aggcatcggt gaccatcgct tcggtgcgca acggcatgat ctccgaaaca
3774061 gcgccgacga atgtggtctt gccggacccg aatccgcccg cgatgacgat cttcgtcgac
3774121 gcggtgccgg atgcctcaga gtgctttaag gccacgcagg gtccttccta tgagttcgtg
3774181 gcgttcgtcg cgggtcgatc ggtcggtcaa ggtcgcgtgc acccgaaggt aaccggacgt
3774241 gaccagatca ccgaccagca cacgcgccac acccaccggc aaatccagcc gagccgagat
3774301 ttccgcgacc gacggactgc caatgcacaa ttgcaagatc ctgcgtcgca tgtcgtaggc
3774361 cggccagcgg ccagccggtc ccgccggcag ggtctgcacc ggcgcctgaa gcggaaggtc
3774421 gacgtcggta ccggtacgtc cggcggtcag cgtgtagggg cggaccaggc ccgccttcgg
3774481 tctatcgccg gcaggattga acaacgccgc ccacccgctc gacaaggatg gccatctcat
3774541 aaccgatctg gccgatatcg catccggtcg cggccagcgc cgccagcgcc gacccgtctc
3774601 ccacctgcat caacagcagg tagccgttct gcatctcaac caccgactgc agcacctgcc
3774661 cgccgtcgaa cagttgcgcg gcgccgccgg ccaggctggc cagcccggac gtcaccgcgg
3774721 ccaactgatc ggcgcgttcg cgtggtagat gttcgctggc cgccacggga agcccgtcga
3774781 ccgacaccag caatgcatgg gccaccccgg gaacctcgcg ggcgaacttc gacaccagcc
3774841 agtcaagcgg gctgtccggc aagcgggctt tcattgctga ttgggtccct gactgctctc
3774901 gcgggcatgc gaccgcccgg tgcgcacgcc gccgaaatgg ctgctgatgg aggcacgaac
3774961 cgcgtcgggg tcgcgtaccg cagccgcgtg ccgcggcgct cggccgggat gaagtccgcc
3775021 gttggatgct agcgctgcac ccggatgctc ccgatcgggt ccctcaggca ccgccgcccc
3775081 cggcactaac cgggccccgg gttcgcgcac cggcaggccg tagtccgtgc gggactgcac
3775141 gggcttgtcc gcggcctcgg cggccgccga ccagccgtgg tcccacaccg acttccagtc
3775201 cagatcgggg ctgtgggcca gctcgtgcgg gtcacccacc atctcggaga gcatccgccg
3775261 gtagatgacg tcgtcatcaa ccgggcccgc cggtggcgcg ggtttggcgg gcggcggcgc
3775321 cggtcgcggt tctggtgcgg gcggttgttt gggctcctgt tgaaacctat cctcccacca
3775381 gggtgttttc agctcgcgcc gccgctgctg catcggctgg gccgggacgt cggcgatgcc
3775441 actggacccc ggggtacggc gcgggagcaa cgtgaccggt ggtagcggcc cgatggcggc
3775501 gggaacgtcc gtcggatcgg ccgccgcggg ttcaggacac ggcggcttga tcgcaaatac
3775561 ccgcggcttt ggcggctgcg ctggggccgt cccctcgagc acggctagcg gcaggtagac
3775621 ctcggcggtg gtgccggtgc cctgttcacc ggtcaccgga ccgcgcagcc cgactcggat
3775681 gccgtgccga ccggccagcc ggccgactac gaacagaccc atgtgccggg cactatccgg
3775741 ggtgacctca ccgccggccc gcagccgcat attggccatc cgccgatcgg catcggtcat
3775801 gcccaggccg gaatccgaga ttcgcagcag aacactgcct tcgctgccga ttgcggcggc
3775861 aacccgaacg ggtgtggtcg gtgacgagta gcgcaacgcg ttgtcgatca gctcggcaag
3775921 cagatgaatg acgccaccag ccgctgcgcc gactaccgca cagtcgggta ccctcgcgat
3775981 gtcgacgcgg cgatagtcct cgacctctga cacggcggcg ctgatcacgg ttgacagcgg
3776041 caccggctcg cggtggtcac gggtaatctg cgcaccggcc agcaccagca ggttggcgct
3776101 gttgcggcgc agccgggcgg ccaggtgatc gagccggaaa aggctgtcga gtcgggcggg
3776161 atcctcctcg ttgcgctcca gttggtcgat gaccgacagc tgctggtcga ccagggaacg
3776221 gctacgccgc gacatggtct caaacatctc gttgaccagc agtcgcaacc gcgtttcctc
3776281 gccggccagc aacagggccc gggtgtgcag ctcgtcgacc gcatgcgcga cctgaccgat
3776341 ttcctcggtg gtgtacaccg ccagtggctc ggggatcggc tcgtcgccgg cgcggaccgc
3776401 cgcgatctcg ccgtcgagat cggtatgagc aaccttgagc gccccatcac gcagtacccg
3776461 catcggcccg accagcgtgc gcgccaccac caacacgacg acgatcgcgg tcgcgatggc
3776521 ggccaacacc agcacggcgt cgcgaatcgc ggcatcccgc cggtcggtgg cctggctttg
3776581 caccgacttc gtcaccgcct cggtggtgtc ggtgatcacc tgctcggcaa tgtcgcgggt
3776641 gatctgtatc gagtgcagca gctctgggtt gttgaccagt gcaacggccg gatcggacat
3776701 gatcgccatc ctggtcacca tttgctgctg caggttcttg gtgtccggcg agcctgcacc
3776761 gagcgccgcg ctcatcccga acagcgtcga gggttcggtg ccggccaggg taaccatcgc
3776821 gctgcgcagt tgcggctcgg caaggtcggc gccgcgagtc accaggatct cctgcatcgt
3776881 catctgcccg cgggcgccaa cggctcggct caaaccctgc acctgggttc ggatttgctc
3776941 gctgtcaacc cgcaccgacg cgtcaatcac gttctgggcc gtcaacagca gcggcgcgta
3777001 ggcggtgacc cgatcccgca agccgatgct gtcggccagc accttatcca gcagcgcctg
3777061 accgccgttg agcagcgtgt tcactcccga ccgcacgtct gcgatgacgt cggtgtcggc
3777121 cagtcgcgtc tgcagctcgt acttgcgggc ggtgaagttt ttctgcgccc cctccacatc
3777181 gtgtccggtc gagctggcca gcacggcgac gtccagcgcc gacatgtatt tcgtgatcgc
3777241 gggtatcatt tcggcgcgcg cggcgaccag ccgcaggccg ctggtgctgg ccatcgcagc
3777301 ctcgacccgc aatcctgcta acaccatcgc cactaccagc ggcagaagcg cgatcgtgaa
3777361 cactttccat cggaccggcc agttgcgcgg cgaccaggac ggcgggcgtt gctgaggttt
3777421 gccgcgggcc ggttgagccg gggcggaaat atcagaagcg gccgccgcga ccgggatggt
3777481 cgggcgggcg aacatggtca cgtggccgcg gccgtgccac cggccgcacc cttatgcagc
3777541 gctcgaaaaa cggagagact catagacttc ctgctcatgc cttgatgccg tccgccccag
3777601 ccggccgggc gcggacgtaa acaactggca atccgacgag tatgacagcc cacggccgag
3777661 gtctccaccg ctgtcaccga gcatgtcacc ggacaggccg gcaaacgggc accgggcgct
3777721 ttgccatgat cggcggatgt tccggctgct gttcgtatct ccgcgtatcg cccccaacac
3777781 cggcaacgcc atccggacgt gcgccgcaac cggctgtgaa ctgcatctgg tcgagccgct
3777841 cggcttcgac ctgtccgaac ccaagctgcg acgggccggg ctggactacc acgacctggc
3777901 ctcggtcacc gttcatgcct cgctcgcgca cgcctgggag gcgctgtcgc cagcgcgggt
3777961 gttcgccttc acggcgcagg cgacgacgtt gttcaccaac gtcggctacc gggccggtga
3778021 cgtgttgatg ttcgggcccg aacccaccgg cctggacgag gccaccctgg ctgatacgca
3778081 catcaccggg caggtgcgca ttccgatgct ggcgggccgg cgctcgttga acctgtccaa
3778141 cgccgcagcc gtcgcggtct acgaggcctg gcgtcagcac ggctttgccg gggcggtcta
3778201 gtcgcgacca aggtgacacc gaaccagccg gtatgcgcac aacgaagctc atcggcgtcg
3778261 ggcgccggac aggagcaccc aaccggtgac agcacaccga acgcaacccg ggcgatcaca
3778321 tcggaccacg acatcccggg aaaatcgatg ccggtgagct tgcgcgtcca gctaccacca
3778381 ccgtcagcgg tgacaccttc accggcaaca acggcagcgc aggcgcagct gtcagcggcg
3778441 gcgcgcagcg aaggcgttgc ggtcaatgaa tctgccgcaa accccacgcc cgttggccca
3778501 tattgcgcta gcatccgggt gttgtgatct cgcaggttgc gtgctggcag cctgggggtg
3778561 ggttgtgatg tcgtttgtcg tagcagtccc ggaggcattg gcggcggccg cgtcggatgt
3778621 ggcgaacatc ggttctgcgc taagtgccgc gaatgcagcg gcagccgccg gcacaacggg
3778681 gctactggca gccggtgccg acgaggtctc ggccgccctg gcgtcgctgt tttccgggca
3778741 cgctgtgagc taccaacagg tcgcggccca ggcgacggcg ttacacgatc agtttgtcca
3778801 ggccttgacc ggtgccggcg gatcgtacgc cctcaccgag gccgccaacg tccagcagaa
3778861 tctgctgaac gcaattaacg cgcccactca ggcgctgttg gggcgcccgt taattggcga
3778921 cggggctgtc ggcaccgcca gcagccccga cgggcaagat ggcggtctgc tgttcggcaa
3778981 cgggggcgcc ggctacaaca gcgccgccac gcccggaatg gccggcggca acggcggcaa
3779041 cgccggattg atcggcaacg gcggtactgg cgggtcgggc ggtgccggcg cggccggtgg
3779101 cgccggcggc agcggcggct ggttgtacgg caacggcgga aacggcggca tcggcgggaa
3779161 tgcgatcgtc gcgggcggtg ccggcggcaa tgggggcgct ggcggcgccg ccggattgtg
3779221 gggcagtggc ggcagcggcg gccaaggcgg caacggtctg accggcaacg acggcgtgaa
3779281 tccggccccc gtcacaaacc ccgcgctaaa tggcgccgcc ggcgacagca atatcgagcc
3779341 gcaaaccagc gtcctgatcg gcacccaagg cggtgacggc acgcccgggg gtgctggcgt
3779401 caacggcggc aacggtggcg cgggcggaga cgccaatggc aaccccgcaa acacctcgat
3779461 cgccaacgca ggcgccggcg ggaacggcgc cgccggcggt gacggcggtg ccaatggcgg
3779521 tgcgggcggc gccggcgggc aggccgcgtc cgccggtagt tccgtcggcg gtgacggcgg
3779581 caacggcggt gccggcggta cgggcacgaa cgggcacgcc ggcggtgcgg gcggcgccgg
3779641 cggtgccggt ggtcgcggcg ggtggctggt cggcaacggt ggcaacggtg gcaacggtgc
3779701 cgccggcggc aacggcgcca tcggcggtac cggtggtgcc ggcggcgtcc ccgccaacca
3779761 gggcggtaac agcgccctag gcacccagcc ggtcggcggc gacggcggcg acggcggcaa
3779821 cgggggcacc ggaggcaccg gcgggcgtgg cggcgacggc ggatccggcg gcgcgggcgg
3779881 cgcgagcggt tggttgatgg gcaacggcgg caacggcggc aacggcggca ccggcggctc
3779941 aggcggtgtc ggcggcaatg gcggcatcgg cggtgacggc gccggcggcg gaaacgccac
3780001 gagcacgtcg agcatcccct tcgacgccca cgggggtaac ggcggcgctg gtggcgacgc
3780061 tggtcacggc ggaacgggcg gcgacggcgg tgacgggggg catgccggca ccggtggacg
3780121 tggcgggtta ctggccggcc agcacgccaa ctccggcaat ggcggtggcg gcggtaccgg
3780181 cggtgccggg ggcacccatg gcacccccgg cagcggcaac gcaggcggca ccggcaccgg
3780241 taacgctgac agcacaaacg gcgggccagg cagcgacggc ctcggcgggg acgcgtttaa
3780301 cggcagtcgc ggcaccgacg gcaaccccgg ctaattacca gccgttccag tgcgtcacgc
3780361 tctcggccgg cagccgcttg gccggccgga agtcgatgcc ttgtgtgtag gcgatcggaa
3780421 gcagcccgcc ttggctgtat tcgtcgtagg gaatgccgag cacgtcggcc accttgtgct
3780481 cgccgttgtc gagcaggtgc agcgtcgtcc agcacgaacc cagcccgcgg gagcgcagcg
3780541 ccaggcagaa gctccacacc gccgggaaca gtgaggccca aaacgacacg ccacccaccg
3780601 ccgactcgtc ttcccggcct ttcaggcagg ggatcagcag caccggcgcc cggtgcatgt
3780661 gttcggcgag ataggtcgcc gaatcgcgga cccgccccat ccgctcgccg cgggtgtcgc
3780721 cgtcggggta ctcgggcgcc ggcccgctga ggtagccccg ggcgttggcc aggtagacgt
3780781 cggcgatcgc ctttttcttg gcggcgtcct cgacgaacac ccactgccag ccttgggaat
3780841 tggaaccggt gggcgcctgc agcgccagct cgaggcattc catcagcacg tcgcgtggca
3780901 ccggcttgtc gaaatcgaga cgcttgcgca ccgagcgggt agtggtcagg acctcgtcga
3780961 cggacaggtt gagggtcatg tgggcaggct accgttgggc catgagcgtc gaactgacac
3781021 aagaggtttc tgccaggctc acgtccgacc tttacgggtg gttgaccacc gtcgcccgat
3781081 cggggcagcc ggttccgcgg ctggtgtggt tctacttcga cgggaccgac ctgacggtgt
3781141 actccatgcc tcaggcggcc aaggtcgccc acatcaccgc ccatccgcag gtcagcctga
3781201 acctggactc cgacggcaac ggcgccggga tcatcgtggt gggcgggacg gcggcggtgg
3781261 tggccaccga tgtcgactgc cgcgacgacg cgccgtattg ggccaagtac cgcgaggatg
3781321 ccgcgaagtt cgggctgacc gaggcgatcg ccgcctacag cacccggctg aagatcaccc
3781381 cgacccgggt gtggacgacg cccacgggct gagcgggctg gcccccgctc gccgccagag
3781441 tgaaatccac gacgcgtttg cggcgtgtcg cgtcgcccgt ttcactgtcg gcgcagaggt
3781501 tcaccggaag tcgcgcgagc gcgcgccgac cgccagggtg aggcggccca tccgttcggc
3781561 gacgacggtg attgcgccgc tggcgttttg gacctggccg cggatcagca gcgccggcgc
3781621 cgtgtgcgcg agcttgcggt gtcgcgccca caccccgggc gtgcagagca cgttgaccat
3781681 cccggtctcg tcttcgaggt tgatgaacgt caccccctgg gccgtggcgg gtcgctgccg
3781741 atgagtcacc gcgccggcga tcagcacgcg gtcgccgtcg gacaccgatc ccagcctctc
3781801 ggcgggcagc acccccatcg cgtccaggtc cgcccgcagg aactgggtcg gatagctgtc
3781861 cggggagacg ccggtggccc acacgtcggc ggcggccagc tccagctcgc tcatccccgg
3781921 cagcgccggg atgtgcgacg acgagcccac cccgggtaac cggtccggcc ggcccgtggc
3781981 cgcggccccg gccgcccaca gcgcctcccg ccgagacatg ccgaagcagc ccagcgcccc
3782041 ggccgtcgcc agcgcttcga cctgcggcac ggaaagctgc acccgcgacg tcaagtccgg
3782101 cagggaggtg aacgggccgt tggctgttcg ctccgcgacc agcttctcgg ccagctcggc
3782161 gccgaggtag cggacggcgc ccaagcccaa acgcacctcc gttccggcgt tctcacacgt
3782221 ggcgtgcgcc aggctggcat tgacacacgg gccgtgcacc gccacgccgt gccggcgggc
3782281 gtcggccacc agcgactgcg gcgaatagaa acccatcggc tgggcgcgca gcagcgccgc
3782341 acagaacgcc gccgggtggt gcagcttgaa ccacgccgag tagaacacca gcgacgcgaa
3782401 actcagtgcg tggctctcgg ggaagccgaa attggcaaac gcctccagct tttcgtagat
3782461 ccggtcgatc acctcgtcgg gggcgccgtg cagcgcgcgc atgccgtcgt agaaccggcc
3782521 gcgcagccgg cgcatgcgtt cggtggagcg tttggacccc atggcgcggc gcagctggtc
3782581 ggcctcggcg gcggaaaagc cggcgcagtc gaccgccaac tgcatcagct gctcctgaaa
3782641 cagcggcact cccagcgtct ttcgcaatgc cggcgccatc gacgggtgct cgtagatgac
3782701 cgggtcgacg ccgttgcgcc gccggatgta ggggtgcacc gatccgccct ggatgggccc
3782761 ggggcggatc agcgccacct ccaccaccag gtcgtagaac actcgcggct taaggcgcgg
3782821 cagggtggcc atctgcgcac gtgactccac ctggaacacg ccgacggaat cggcgcgggc
3782881 cagcatctca tacaccgccg gctcggagag gtcgaggcgg gccaggtcca cctcgatgcc
3782941 cttgtgctcg gccaccaggt ctttcgcata gtgcagcgcc gagagcatgc ccagcccgag
3783001 taggtcgaat ttcaccaagc cgattgccgc gcagtcgtct ttgtcccatt gcaggacgct
3783061 gcggttggcc atgcgcgccc attccaccgg gcacacgtcg gcgatcgggc ggtcgcagat
3783121 gaccatgccg ccggagtgga tgcctaggtg ccgcggcagg ttgcggatct gggtggccag
3783181 gtcgatcacc tgctcgggga tgccgtcaac gtcgtcggcc tgcccggtcc agtggctgac
3783241 ctgcttgctc cacgcgtcct gctggcccgg cgagaagccc agggcgcggg ccatgtcacg
3783301 caccgcgctg cgcccccggt aggtgatgac gttggcgacc tgggcggcgt agtcgcggcc
3783361 gtatttgtgg tagacgtact ggatgacctt ttcgcgctga tccgactcga tgtcgatgtc
3783421 gatgtcgggt ggcccgtcgc gggcgggcga taagaagcgc tcgaacaaca gctcgttggc
3783481 caccgggtcg acggcggtga cgcccagggc atagcagacc gcggagttgg ccgccgatcc
3783541 cctgccctga cacaggatgt cgttgtcccg gcaaaaccgg gtgatgtcgt gcaccaccag
3783601 gaagtagccc ggaaatctca gttgggcaat gactttcagc tcatgctcga tctgggagta
3783661 cgcccggggc gcgctcttgg gcggcccgta acgctcgcgg gcgcccgcca tgaccaacga
3783721 ccgcagccag ctgtcctcgg tgtgcccgtc gggaacatcg aacggcggca gccgcggcgc
3783781 gatgagctgt aggccaaagg cgcaccgctc gccgagctcg gcggccgcgg tcaccgcctc
3783841 ggggcaccac gcgaacaacc gggccatctc ctccccggac cgcaggtgcg ccccacccag
3783901 cggagccagc cacccggccg cggagtccag cgaccgccgg gcccggatgg ccgccatcgc
3783961 catcgccagc cgcccacgtg acggatccgc gaagtgcgcc ccggtggtgg cgacgatgcc
3784021 gacaccgaag cgcggcgcca gtccggccag cgcggcgttg cgttcgtcgt cgagcgggtg
3784081 accatgatgg gtcagctcga tgctgacccg gctgggggtg aaccggtcca ccagatcggc
3784141 cagcgcccgc tgcgccgcgg ccgggccacc ctgggaaagc gcttggcgca catggccttt
3784201 gcggcagcca gtcaggatgt gccagtgccc gccggcggcc tcggttagcg cgtcgaagtc
3784261 gtagcgcggc ttaccctttt cgccgccggc cagatgcgcc gccgccagtt gccgcgacaa
3784321 ccgccggtag ccttccgggc cgcgggccaa caccagcagg tgcgggccgg gcggatccgg
3784381 ccgctcggtg cgagccgtgg cgcccagtga cagctcggcg ccgaagaccg tgcgcacgtc
3784441 gagttccgcg gccgcttcgg cgaaccgcac cgccccgtac aggccgtcgt ggtcggtcag
3784501 cgccagggca cacaggccca gccgggcggc ctcctcgacc aactcctcgg gcgtgctggc
3784561 cccgtcgagg aagctgtacg ccgaatgcgc atgcagctcg gcatacgcga cggacgatcc
3784621 gacccgttcc cggcccggcg gctggtacgc cccgcgcttg cgggaccgtg ggacgtcccc
3784681 atccgcgtcg aacgccggca ccccggcatg gcgcggcttg ccgttaagca cccgttccat
3784741 ttccgcccag ctcggcggcc cgttgctcca ccccacattc cacagtatat cgaacaattg
3784801 ttcgatacag cgcagttgtt cagcacatct tcacctgcga aacatgttct taaccgtttg
3784861 ggccttctgc ttccggtgcg gtccggcgga cacttatacc tggggtcgca aaacgacggt
3784921 ggggacttgt catggcacaa ctgacggcac tggatgcggg ttttctcaag tcccgcgatc
3784981 cggagcggca cccgggcctg gcgatcggcg cagttgccgt cgtcaacggt gccgccccca
3785041 gctacgacca gctcaaaacg gttctcacag aacggattaa gtcgatacct cgatgtaccc
3785101 aggtgttggc gaccgagtgg atcgactatc cgggattcga cctcacccag cacgtgcgac
3785161 gggtggcgct tccccggccc ggcgacgaag ccgagctgtt ccgggccatc gcgctggcac
3785221 tggagcgtcc cctcgacccg gaccgcccgc tgtgggaatg ctggatcatc gaaggcctca
3785281 acggcaaccg ctgggcgatc ttgataaaaa tccaccattg catggccggc gccatgtcgg
3785341 cggcccacct gctggccagg ctctgcgacg atgccgacgg cagtgccttc gctaacaatg
3785401 ttgatatcaa acagattccg ccgtatggcg atgcgcggag ctgggccgaa acgctgtggc
3785461 gaatgtccgt cagcatcgct ggcgccgtct gcacggccgc ggcacgcgcc gtcagctggc
3785521 cggcagtgac gtcaccggcc ggcccggtca ccaccaggcg gcggtaccaa gcggtgcgcg
3785581 ttccccgcga cgccgtcgac gccgtgtgcc acaagttcgg ggtgaccgcc aacgacgtcg
3785641 cgctcgcggc catcaccgag ggcttccgaa cggttctgct gcaccgcggc cagcaaccgc
3785701 gcgccgactc actgcgtacc ctggagaaaa ccgatggcag ctcggccatg ctgccctatc
3785761 tccccgtcga gtacgacgac ccggtgcggc gattgcgcac cgtgcacaac cggtcacagc
3785821 agagcggccg tcgtcaaccc gacagtctgt cggactatac gcctctcatg ttgtgcgcca
3785881 agatgattca cgcgctagct cggttaccgc aacaaggcat cgtcaccctg gcgaccagtg
3785941 cacccaggcc acgccaccag ttacggctga tgggccagaa gatggaccag gtgctgccca
3786001 tcccgcccac cgcactgcag ctgagcaccg ggatcgcggt cctcagctac ggcgatgagc
3786061 tggtgttcgg catcaccgct gactatgacg ccgcgtccga aatgcagcag ctggtcaacg
3786121 gtatcgaact gggtgtggcg cgtctggtgg cgctcagcga cgattccgtg ctgctgttta
3786181 ccaaggatcg gcgtaagcgt tcatcccgcg cactccccag cgccgcgcgg cgggggcggc
3786241 cctctgtgcc gaccgcccga gcgcgtcact gacgccatct ccgtcggcgt tgacccccgt
3786301 gagagggtgg gtcgtgcgca agttgggccc ggtcaccatc gatccgcgcc gccatgacgc
3786361 ggtgctgttc gacaccacgt tggacgccac ccaggaactg gtccggcaac tccaggaagt
3786421 cggtgtgggc accggcgtct tcggtagtgg cctagacgtt ccgatcgtag cggccggccg
3786481 tctggcggtg cggccgggcc ggtgcgtggt cgtctcggcc cactcggcgg gcgtcacggc
3786541 cgcacgcgaa agcggatttg cgctgatcat cggtgtcgac cgcaccgggt gtcgggacgc
3786601 attgcgtcgc gacggcgccg acacggtggt caccgaccta agcgaggtca gcgtgcgcac
3786661 cggggaccga cgcatgtcgc agctgcccga cgcgttacag gcactcggcc tggccgacgg
3786721 cctggtcgcc cggcagcccg cggtgttctt cgacttcgac ggcacgctgt ccgacattgt
3786781 cgaggatccc gacgcggcct ggctcgcccc cggtgccttg gaggcactgc agaagttggc
3786841 cgcgcgctgt ccgatcgcgg tgctcagtgg ccgcgacctg gccgacgtga cacagcgggt
3786901 gggtctgccc ggcatctggt atgccggcag ccatggtttc gaattgaccg cacccgacgg
3786961 aacgcaccac cagaacgacg ccgcggcggc agccataccg gtgctgaaac aggcggctgc
3787021 cgagctgcgc cagcaacttg gacccttccc gggtgttgtg gtggagcaca agcggtttgg
3787081 cgtcgccgtg cactaccgca acgcggcccg ggaccgggtc ggcgaagtcg ccgcggcggt
3787141 gcgcacggcc gagcagcgtc atgcgctgcg ggtgacgacg ggccgcgaag tcatcgagtt
3787201 gcgtcccgat gtcgactggg acaaggggaa aacgctgctg tgggttcttg accatctgcc
3787261 gcattcgggc tcggctcccc tggtgccgat ctacctcggc gacgacatca ccgacgagga
3787321 cgctttcgat gtggtcggcc cccatggtgt tccaattgtg gtgcgccaca ccgacgacgg
3787381 tgaccgcgcc accgccgcac tgtttgcgct ggacagtccc gcacgggtcg cggagttcac
3787441 cgatcggctg gcgcgtcagc tccgtgaggc tcccctgcgg gcaacgtgag acgcggtgcc
3787501 gccgcgggcg atacgctccg accgtcaacg aggaggacgg ccatgtggtt tgcattggtg
3787561 aacccggaga tgctggccgc ggcggcgaca gacttgggcg gcatcaggtc agggatcagc
3787621 gccgcctatg cgcgtcctct gcggtgacct ggctggtagc ttaggcacgt ctttatcgac
3787681 accgggtgct gccagagaac tcgagacgcg gcacaggtcg gcaccatgag gcggcgtgca
3787741 atgacgaaga tggacgaggc tagcaatccg tgcggcgggg acatcgaagc tgagatgtgc
3787801 cagttgatgc gcgagcaacc acccgccgaa ggcgtcgtcg atcgtgtcgc gctgcaacgc
3787861 catcgaaacg ttgcgttgat cacgctgagc catccgcagg cgcagaacgc actcaacctg
3787921 gcgagctggc gtcggctgaa gcggctgctg gacgatctcg ccggcgaatc ggggctgcgg
3787981 gcggtggtgc tgcggggcgc cggtgacaag gcgttcgccg cgggtgccga catcaaggag
3788041 tttccgaaca cccgcatgag cgccgcggac gccgcggagt acaacgagag cctggccgtc
3788101 tgcctgaggg cgttgaccac gatgccgatc ccagtcatcg cggcggtccg ggggctcgcc
3788161 gtcggtggcg gctgtgagct ggcgacggcc tgcgatgtgt gcatcgcgac cgacgacgcg
3788221 cgcttcggca tcccgctggg caagctcggc gtcacgacgg gcttcaccga ggcggacacc
3788281 gtcgcgcgcc tcatcggtcc ggcggcgctg aagtatctgt tgttcagcgg agaactgatc
3788341 ggcattgagg aagccgcccg ctggtgattg gtgcaaaagg tcgtcgcacc acaggatttg
3788401 gcggccgcga cggccaaact ggtcggccag gtctgtcggc aatccgcggt gaccatgcgt
3788461 gcggcgaagg tggtcgccaa catgcacggc cgagcgctga ccggcgccga caccgatgcg
3788521 ctgatccggt tcggtgtcga agcctacgag ggggcggacc tacgcgaagg ggtggcggcc
3788581 ttcagccagg gacgcccacc caaatttgat gattagcgcc atgaccgatg ctgacagtgc
3788641 ggtccctccc cgactcgacg aggacgcgat ctcgaaactc gagctgaccg aggtcgccga
3788701 cctgatccgc acccggcaac tgacgtcggc agaagtgacc gagtcgacgc tgcggcgtat
3788761 cgaaaggctt gacccccagc tgaagagcta cgccttcgtc atgccggaaa ctgcgctagc
3788821 ggcggcacgt gccgccgacg ccgacatcgc gcgcggccac tacgagggtg tcctgcacgg
3788881 cgtaccgatc ggcgtgaagg atctctgcta cacggtcgac gccccgaccg cggccggcac
3788941 caccatcttt cgtgactttc gcccggcata cgacgcgacg gttgtcgcga ggttgcgcgc
3789001 ggccggcgcg gtgatcatcg gcaagctggc catgacggag ggggcctatc tcggctatca
3789061 ccccagtctg ccgaccccgg tcaatccctg ggacccgaca gcgtgggcgg gcgtgtcctc
3789121 gagcggctgc ggcgtggcca ccgcggcggg attgtgcttc ggctcgatcg ggtcggacac
3789181 cggggggtcg attcgctttc cgacgagcat gtgcggcgtc accgggatca aaccgacgtg
3789241 gggccgggtc agccgtcacg gcgtcgtcga acttgcggca agctacgacc acgtcgggcc
3789301 gatcacccgt agcgctcacg atgcggcggt attgctcagt gtcatagcgg gatccgatat
3789361 ccacgatccc tcgtgctcgg cggagcccgt tccggactat gccgccgacc tcgccttgac
3789421 acggattccg cgtgtcgggg tggactggtc gcagacgacg tcgtttgacg aggacaccac
3789481 ggcgatgctg gccgatgtcg tcaaaacgct cgacgacatc ggatggcccg tcatcgacgt
3789541 caagctgccc gcgcttgcgc cgatggtggc agcgttcgga aaaatgcgcg cggtcgaaac
3789601 ggcgatcgcg catgccgaca cctacccggc gcgcgccgac gagtacgggc cgatcatgcg
3789661 cgcaatgatc gacgccggac acaggctggc tgcggtggaa tatcagacgc tgaccgagcg
3789721 gcgtctggaa ttcacgcgat cgctgcgtcg cgtgttccac gacgtggaca tcctgctgat
3789781 gcccagcgcc ggaattgcct cgcccacact ggaaaccatg cgcgggctcg gacaagaccc
3789841 ggagctgacc gccagactgg cgatgccgac agcaccgttc aacgtcagcg gtaatcccgc
3789901 gatatgccta ccggcgggaa cgacggcgcg cggaacgccg ctcggcgtcc agttcatcgg
3789961 ccgtgaattc gacgagcact tgctcgtccg agccggccac gcatttcagc aagtcaccgg
3790021 gtatcatcgc cgacgcccgc cggtgtgaaa aaccctcggc cgcaaaaggc ttgcgaatgt
3790081 cgcaccgaag gtcgcggcga atcgccttac tggtatgttt acgaacacaa tctgtggcca
3790141 tcaagggagg acgcgttgag cattagcgcg gttgttttcg accgtgacgg tgtgctcacc
3790201 agctttgact ggacacgtgc cgaggaggat gtgcggcgaa tcacgggcct accattggag
3790261 gagatcgaac gccgctgggg tgggtggctc aacggattga ctatcgacga cgcgttcgtt
3790321 gaaacccagc caattagcga gttcctctcg agcctggcgc gcgagctcga gctcggttcg
3790381 aaggcaagag acgagctagt gcgcctcgac tacatggcgt tcgcccaggg atatccagac
3790441 gcgcgtccag cccttgaaga agcccggcgc cgtggcctca aggtcggtgt tctcacaaac
3790501 aacagcctgt tggtcagcgc ccgcagcctc cttcagtgcg ccgctctgca cgacctcgtc
3790561 gacgtcgtgc tgagttcgca gatgatcgga gctgccaagc ctgacccgcg ggcctatcaa
3790621 gcgatcgcgg aagccctcgg cgtctcgaca acgtcatgcc tgttcttcga cgacatcgcc
3790681 gactgggttg agggcgcacg gtgcgcgggc atgcgcgcgt acctcgtgga ccgttccgga
3790741 caaactcgcg acggcgtcgt tcgcgatttg tccagccttg gagcgatcct ggacggcgcg
3790801 ggaccatgac cgaacgtgac gagccggaca tcgccgacag ggacgcctca ttggttactc
3790861 tcatcgacca gccgcagtgc acttaggatg gcagccttaa ctaccgtcgc cgagcagtaa
3790921 agtgtcttgg caatccacaa cggcgcgtat ggcggttcgc agtgttgcga tagccaccca
3790981 cccgcgcgac tgatctgcgc cgacaaggat gtgccgctgt gcctctgcca atgcgccaga
3791041 gcttgaatgc aatatgctgt ctcttccgca gtcgcttggc cgtcgaaaaa tccccacgag
3791101 ccatcgggcc tctgcgtatt aagaatccac ccaatcgcat ctgagcatag ggcatcatca
3791161 tagttactgg cagcacatat cagatgcgca gtcgtataat atgccgatcg gtgccactta
3791221 tcccgccagc agaaccgtcc aggctccttg cttgatcgga tgaattccag aacctttcgt
3791281 actcgtggat gacatttgtc gtagcccgcc tgcttcaacg caccgagcac gtggacgttc
3791341 gtcgatatcg aggggccgac ttcgtgaaag taggtacgga accaatcggc gtcttcgaat
3791401 tgtaatacgg ctccgatatc cggcgaccgt ccaaacttcg acaaaacatc gtaggccaca
3791461 cttgtggtgt cacaatcttc caaggtggaa tttcctgtcc accccacacc tcgaccacgg
3791521 acccaatgtt gttcgacatg gtcaagatag ggtaggtacg tacgaacgat ctcaggatcg
3791581 gacaaatcaa tatccgtacg cgagagattc catagagacc aaacaatttc aaaaatctcg
3791641 gcttgataga aggccggcgc accgccatcg ccggcttgaa ttatcgatga gatgtacgcc
3791701 aaggcccgct tgtctcctgg tttaacatgt aacgcgaagt aggctgacgc tgatggcgaa
3791761 tacttgaccg atccatttgt ctcctgcaag ttatcgacat ccaacatacc gacaccgtct
3791821 tggccggcca gttctacgga gaaagctgcg gtgatatgtt tattgatttt gcttccgccg
3791881 agttttctca acttctgctc acgcactccg acaagctcgc cgaggatgga ttcctcgtgg
3791941 caaatggcaa ggccaagtcg cgccgcctca gccatcagcg taggtgcgat taactcaaac
3792001 ccgacggttg cgtcttttat atcaagttga gggccttcga aagcacccga ggtaaggttc
3792061 ttcagggcta gcaagccttt ttcaacttgc gctgcgcgcc tccgacgatg cttattcgac
3792121 gtgaggctga tcatggccgc caaagtggag agcagtcgat cttcgtagca gaaagggaac
3792181 tcggctcccc atgagccgtc aggaagctgg cgctcgcaaa gccagttgag ggcgaggtcg
3792241 cttagctcat catcgagctg gcccagcttc gcgacccacg cggtgtcata ggctgtgctc
3792301 gagatgccgt tgcctagtgc cgctttcgct agcagagtcc tgaaagtctc cataccatca
3792361 gccctccgcg aaccagattc catcatgaac acaacccaca ccgaaaactc tgtcaggctg
3792421 ggctcgatat ctgttgcgca gtacattgag ctgatcggcc gacatcgctg aatagtcagg
3792481 tttgggccgg aaatgacgga gatagatatg atcgtacaag atcctccgga gcgttgtttc
3792541 ggtcatatag tatgagggag caacggtgaa gtatagactc gtttttcctg agctgagcag
3792601 cggaaaatcg aaagtgctga aacgcccaaa tccgatgaac atgtcagcct tgtcaacata
3792661 ctcgccgtaa taaccttcga taatctctct ccgcgtggga ggtttaccat gcgtttcgtt
3792721 ccacgagata gaaaactgcg caacagactc agccgcatcg ttgccaaaaa caccgaagca
3792781 tagtctgtgt tcagtgttgg atgacgtaga gattgttagg tcatcgaatg acttgacaac
3792841 ggctgcccct tgcgcggtcg aaggcaatct tttcttataa tcaccataaa aaagaacgtg
3792901 gacctcgtgt tctttataga acgacagaat ttcctcgtcg ttggcaagca aggccatccc
3792961 ttcgagcgcc tgtacgatat atcgatcacc acgatccaga agatcgtcgc taaagattgg
3793021 cgagattact gtttcgatgc cgtgctcgaa gagcatcttc agaatacgaa ttgattgacg
3793081 caaggcggcc tgctgataat cgtcgtactg cggattacat tcgaggtgaa accagcggcg
3793141 tgtgccatcg aagggaaaga cggatacctt cggtccacgg caacgtacaa tctctgctac
3793201 ggatactaga ggaagatcca agaattcttt ttcgctaacc aagttcatgc ttcctcttaa
3793261 taactatcgc cggaatcagg atggtcttcg ggtccaggga cttcatgtag tgcgttaagt
3793321 agtgatttgc atcttatgcg gattgcgggg ccggtgagtc cgtggctgga aaggatgtgg
3793381 tcgcggctgg cgtggggaat gtaggccggt ggcagtccca gtgtgtaggt gcgcgtccgc
3793441 gggtgtgtcc gcccgatgtg gtggctaagg tgcgcgccga ttcccacgtc ggcaatcgca
3793501 tcttcgacac acacggtgat ccgatggcgg ccagccagct cggtcagtgc cgggctgatt
3793561 ggccagaccc attgtggatc aacgactgtc accccgatct gctcctcgct gaggcaccgg
3793621 gcggcgtcca tgcatggtcg actcatggca cccactgcga ccaagagcac gtcgggtcgc
3793681 caatgcggtg gtggtgtatg caagacgtcg aggccaccga tggtgtgttc ggccgtgatc
3793741 ggttcgcccg gcgccccttt ggggaaacgc acggcggtgg gagccgcggt cgcgatcgcg
3793801 gtacgcaact gttgtcgtag ccgaggcgcg tcgcgcggac aggcgatctg aaacccgggc
3793861 acgcaggcca gcagcgccag atcccacaaa ccgtgatggc tgggtccgtc gggcccggtt
3793921 accccagccc ggtccagcac cagcgtcacg ggtaaccggt gcagcccgat gtcgaacaga
3793981 agttggtcaa aggcgcggtg cagaaacgtc gagtacaccg cgacaacggg atgggttccc
3794041 gcggcagcta gcccggccgc gctggccaac aggtgttgtt cggcgatgcc cgaatcgaac
3794101 acccgatgcg ggtatcgcct cgacagcgcg cctagaccag tgggcagacg catcgccgcg
3794161 gtcagcccga cgacgtcgga tcggtcgtca gcaatgcgcg cgatttcgtc ctcgaacacg
3794221 tcggtccagc tccgctgact gggtgtgcta gcgaggccgg tggcaatgtc gaccaccccg
3794281 caggcgtgca tatggtccct ctcgtcagct tcggctggag gataaccccg gcccttacta
3794341 gtcactgcgt gaacaacaac gggcctagct gccgcggccg cttttcgtag aaccgcgcac
3794401 gtgtcgggga tgttgtgccc atcgaccgga ccgatgtagg taaatcccat gttctcaaag
3794461 aggttcggcc ctcggggtgt gccgacgcga agttcttcta ggtgtgccgc aagagcccca
3794521 gcggtggggt cgtaggagcg gccattgtca ttgagcacga cgatcacggg ccgggtagcg
3794581 gcaccgaggt tgttcaggcc ctcccatgcc acgcccccgg tgagggcgcc atcaccgatc
3794641 accgcgatga cacgtcggtc gcattgcccc tgcagggcca atgctttggc gatgccgtcc
3794701 acccaggcga ggctgaccga ggcatgggag ttctcgaccc agtcatgtgg cgattcatgg
3794761 cggttgggat accccgatag accatcggcc tggcgcagcg tggcgaagtc tttaccgcgg
3794821 ccggtgagca gcttgtgcgg ataggtttgg tgcccggtgt cgaacaccga tgtcgtgtgg
3794881 cgaggtgaac acccgatgca atgcgatggt cagctctacc atgccaagtc ccgcgccgag
3794941 atggccaccg gtagccgtca ctgtttctat gagccgccga cgcatctgca cggccagctc
3795001 tggcagctgg ctttcgggca atgcctgcac atcgcaaggt ccgccgatcg cggtaattga
3795061 accgccccgg tgagtccgga gactctctga tctgagacct cagccggcgg ctggtctctg
3795121 gcgttgagcg tagtaggcag cctcgagttc gaccggcggg acgtcgccgc agtactggta
3795181 gaggcggcga tggttgaacc agtcgaccca gcgcgcggtg gccaactcga catcctcgat
3795241 ggaccgccag ggcttgccgg gtttgatcag ctcggtcttg tataggccgt tgatcgtctc
3795301 ggctagtgca ttgtcatagg agcttccgac cgctccgacc gacggttgga tgcctgcctc
3795361 ggcgagccgc tcgctgaacc ggatcgatgt gtactgagat cccctatccg tatggtggat
3795421 aacgtctttc aggtcgagta cgccttcttg ttggcgggtc cagatggctt gctcgatcgc
3795481 gtcgaggacc atggaggtgg ccatcgtgga agcgacccgc cagcccagga tcctgcgagc
3795541 gtaggcgtcg gtgacaaagg ccacgtaggc gaaccctgcc caggtcgaca cataggtgag
3795601 gtctgctacc cacagccggt taggtgctgg tggtccgaag cggcgctgga cgagatcggc
3795661 gggacgggct gtggccggat cagcgatcgt ggtcctgcgg gctttgccgc gggtggtccc
3795721 ggacaggccg agtttggtca tcagccgttc gacggtgcat ctggccacct cgatgccctc
3795781 acggttcagg gttagccaca ctttgcgggc accgtaaaca ccgtagttgg cggcgtggac
3795841 gcggctgatg tgctccttga gttcgccatc gcgcagctcg cggcggctgg gctcccggtt
3795901 gatgtggtcg tagtaggtcg atggggcgat cggcacaccc agctcggtca gctgtgtgca
3795961 gatcgactcg acaccccacc gcaaaccatc ggggccctcg cggtggccct gatgatcggc
3796021 gatgaaccgg gtaattagcg tgctggccgg tcgagctcgg ccgcgaagaa agccgacgcg
3796081 gtctttaaaa tcgcgttcgc ccttcgcaat tcggcgttgt cccgccgcaa gcgcttcagc
3796141 tcagcggatt cttcggtcgt ggtcccgggc cgtgcgccgg catcgacctg cgcctggcgc
3796201 acccacttac gcaccgtctc cgcgcagcca acaccaagta gacgggcgac ctcactgatc
3796261 gctgcccact ccgaatcgtg ctgaccgcgg atctctgcga ccatccgcac cgcccgctca
3796321 cgcagctccg gcgggtacct cctcgatgaa ccacctgaca tgaccccatc ctttccaaga
3796381 actggagtct ccggacatgc cggggcggtt caaatcaagt ccccgcgtcc gttgcgaatc
3796441 gtggttgtca ttgcgcgcga acctgtttgg gaaggccgaa tcgcaccgtc tcggtcgcta
3796501 tcgagcgttc caccacggtg atcgaggcgt atccgcgaag tgcatcaatc acctgcccca
3796561 ccagtcgtgg cggcgcggag gctcccgcgg tgacaccgat cgtcgagacc gacgacagcc
3796621 attcgggctc aatgtcatca ggcccgtcaa tcaagtaggc cggcgtccca cttcgctgcg
3796681 ccaactcgac cagacgccgc gaattcgacg aattgcacga gccaatcacc aacacaacgt
3796741 cacattcacc gaccatcgat tgcagcgcac gctgtctgtt cgtggtggca tagcagatgt
3796801 cttcagaggg gggttggccc aacgtcggaa acctcgcgcg cagcgcatca atgacatcgg
3796861 cagtttcatc aagtgccagg gttgtctggg tcagatacga tagctgggta ccctcgggca
3796921 ggttcaacgc tgccacatca gcgggtgtct gcaccaataa tgttgaccgc ggagcgacgc
3796981 caagcgtgcc ttcggtctcc tcatgtccgg cgtgcccgat gaagaccacc gtgtcaccgc
3797041 gcgcggcaaa ccgtgcggct tcagcgtgga ctttcgccac cagtgggcag gtcgcgtcga
3797101 cgacctgcag tccccgctca tcagcgcccg cgcgcaccgc cggggaaacc ccatgcgcgg
3797161 agaacaccac gaccgccccc ggcggcggcg gatcgggaat ctcgtcgaga tcctcgacga
3797221 acactgctcc ccggtcccgc aactcggcaa ccacaacagt gttgtgcacg atttgcttgc
3797281 gcacatacac cgggccttcg gccacgtcaa gcactcgctt gaccgtctcg atagcacgct
3797341 ctacaccggc gcaaaacgac cgcggcgacg ccaacagcac cgtgacttca cccgaagcgt
3797401 atccctgtgc gaccggtccc acgaacacct cagccatcag cactcccggc gacatatcag
3797461 ttgcgacaac gcgatcaggt ctggggatcg caccgcatcg ggcagtgccg caatagcagc
3797521 ctggatgcgt tcatcggcgc atcgctgcgc cacatgacca cccccggcca ccttgacaag
3797581 cgcggtagcc cgctcgacat cgcttgctgt cattgcggca ggtgcttgat agagggccgc
3797641 caattcggtc gccgcttcgg atcgcgagtt cagggcggca acaactggca gtgtcgcctt
3797701 acgtcgggca aggtcgttgc cgaccggctt tcccgtcaca ccagggtcac cccagatgcc
3797761 gatcagatcg tcgacgcatt gaaacgcaag acccaactca tggccaaaac gctccaacgc
3797821 agcaatcgtc gcgtcgtctg cattggccac taaagctccc agagcgcaac aacaaccggt
3797881 cagggcggcc gtcttgcccg cggccatccg cagatagtca tcgactgtaa cttcgggctg
3797941 tccctccaat aaacaatcct caaactggcc gatacacaag tccaggcacg acatctgcaa
3798001 tcgccttatc gccctgaccg ccacacactc gtcggtcagg ccggtcagta tccgaacggc
3798061 cgtggcgtgc aacgcatctc ccaacaggat cgcgacgccc acaccccaca cactccatac
3798121 cgtcggccgt cccctgcgag tcgcatcccc atccatcaca tcgtcatgca acaacgtgaa
3798181 gttgtgcacc aactccacag ccgccgacac cggagtagca tcaccgacat caccaccgca
3798241 agccgcggcc gccgcgtaga caagggcggc gcgaaaatac ttgcccgacg atcctgccgc
3798301 tgtggatcga tcggcgttcc accagccaag gtgatatccc gccatcgtcg ccaacggctc
3798361 gcgcatcgac tcaatggccc gatgcagcac agggccacaa tccgctcgag cccgttctaa
3798421 caatgctttc ccaaggtcag cagggacact ccccagaaaa gccgcatcca gagtcaatac
3798481 gcctcccatt cttaacctca ccggagcaac agtgagtcgc tattttcagc gaacgagcaa
3798541 tcggcgatat tgcttcactt cggagatacc caaatatttc aaatatcaac gcaacatgta
3798601 cctatgcccg tcgaccaaca cgaccatcag ggttgttagc aatgatctcg gaattcgagt
3798661 tgtccagacg ccccgggtca tccactacag aaagacacgc ataccctgcg gcgacctata
3798721 cttcccatca cggcgggtag gttgccttcg acaatactgc aacattcaat tgcctggcct
3798781 ttctcggagt atcttgcgga cttgaagctc acacatcggc cggcgtcgaa cgcctcacgc
3798841 tgcagagcag tttagtggat ttcatcagca tcggatatgc ataattgaaa ccacagcact
3798901 ttcataaaca gtgtccagat gatttacacc taatttgggc ggcgaatgct acgcaatggt
3798961 ggtgcgcttc ccaagggagc acaacgcgaa gctaaagcag ttgcacgccg agaccgagcc
3799021 gaaaggtcgc cctgcgggga aggcggccac gggagaattg tgagctcggc ggtcgaccac
3799081 gacgtacccg ccacgccgta gtaatgggca tttgtacatg tacattcgca cacaaggaga
3799141 ggtcttgacg tatctattcc ctctctgcgc gatcgcggcg gaggcggcgg caaccagcct
3799201 gttcaagggc agtttcgggg actttcgcgt ctgctcgccg ggtcacgacg gggcgatcac
3799261 ggccatgccg agcgtcttgg cggcgtcgcg catccggtcg tcgtaggtgc acaaccggcc
3799321 cagatcgacg ccgagccgct gcgccgtcgc caagtggatg gcatcgagcg tgcgcagctc
3799381 gaatggcagc agcccaccag cgagatcgag gacgcgcttg tcgacgcgca gcagatcgag
3799441 atgagccagc gcccggcggc cggctttccg cgctgattca cccttgtcaa gcagggcccg
3799501 catgacctcc gcgcgcgcaa gggcactcga cactcgcggg tggcgggtgc gaaggtagcg
3799561 gcgcagcgcg tccgactctg gctcgcgaac cgcgagcttg acgatcgcgg acgagtcgag
3799621 atagatggcc gccatcaacg ctcgtgctca cgcaggcgcg caagcgtcac cgacggcagc
3799681 tcgacgcccg cgtcgaggtc gagcggttcg ggcagatcaa cgacgtcgag cgtggcacgc
3799741 tcgatctcgc cgcttgccag cagctgctcg tatggaccgc cctgcggcag cggcgagagc
3799801 agggcgacgg gccggccgcg gtcggtgatc tcgatcgtct cgccggcctc gactcggcgc
3799861 agcagctcgc tggcccgctg ccgcagcgca cgcaccccca ccgaggtcat tgtgctaact
3799921 gtagcacaag cggtcggcgt catgggccga cgttcgactc gcgcaggctt taagtaacgt
3799981 cggtgttaat tactaggacc tgaaaaagtc ggcgcgttgt tcctcggttg gttggcgctg
3800041 agctgggagg atggcctcaa tgcccttgtt gcggaaggga ttgaggccat cgtgtttcgt
3800101 actgtaggcg atcaggcatc gttgtgggaa tccgtgctgc ccgaggagtt gcggcggctg
3800161 cccgaagagc tggcccgggt ggatgcgctg ctcgatgatt cggcgttctt ctgcccgttt
3800221 gtgccgttct tcgacccgcg gatgggtcgg ccgtccatac cgatggagac ctatttgcgg
3800281 ttgatgttct tgaagttccg ttaccggttg ggctatgagt cgctgtgtcg ggaggtcacc
3800341 gattcgatca cctggcggcg gttctgccgt attccgttgg agggatcggt gccgcaccca
3800401 accacgttga tgaagctgac cacgcgctgc ggtgaggatg cggtggccgg gctcaatgag
3800461 gcgctgctgg ccaaggcggc cagcgaaaag ctgttgcgca ccaacaaggt ccgtgccgac
3800521 accaccgtgg tggagggcga tgtgggctat cccaccgaca ctggactgct cgccaaggcg
3800581 gtcggctcga tggcgcgcac cgtggcgcgg atcaaagccg cggacgcggg atcggcgccg
3800641 ctcggtgggt cgtcgggccc gcgcgatcgc ctccaagctg cggttacgcg gcgcgcagca
3800701 acgcgatcag gcgcaggcct tcgtgcgccg gatcaccggg gagctagccg ggatcgccga
3800761 gcaggcgctg accgaggctg ccgcggtggt acgtaacgcc caacgtgcgg tgcgccgcgc
3800821 cagtgggcgg cgcaaagcct ggctacgcca ggccatcaac catctcgaga agctgatcgg
3800881 acgcaccgag cgggtggtgg accaggcccg tagccggctg gccggggtaa tgcccgactc
3800941 aagcagccgc ctggtcagtc tccacgatgc cgacgctcgc ccgatccgca agggacgatt
3801001 gggcaagccg gtcgagttcg gctacaaggc ccaggtcgtc gacaacgccg acggtgtcat
3801061 cctggaccac agcgtcgagc tcggaaaccc cgcagatgca ccgcaattgg cacccgccat
3801121 cgaacggatc agccgccgca ccggacgccc accacgggca gtgaccgctg atcggggctg
3801181 cggagacgca tcggtcgaag atgatctcca ccagctcggg gtgcgcaacg tggccatccc
3801241 acgcaagagc aaacccagcg ccacccgccg cgcattcgaa caccgacggg cattccgcga
3801301 caagatcaaa tggcgaaccg gatccgaagg acgcatcaac cacctcaagc gcagctacgg
3801361 ctggaaccgc accgaactca ccggcatcac cggcgcccga acctggtgcg gacacggcgt
3801421 cttcgcccac aacctcgtca agatcagcac cctggcagcg tgacagacac ccgcgcccac
3801481 cccgaccacg ccacgcaggt cgcccagccc gccgccgtca atgcaaccgc gactttttca
3801541 ggtcttagta attagtggcc gccgctttgg gtccaccggg gccctgcggc gaaacaccag
3801601 acgtgatgcc gtgatcggcg atacccttcg acccattgaa gggagaacag ccatgtcgtt
3801661 tgtgatcgcg aaccccgaga tgctggcagc ggcggcgacc gatttggccg gcatccggtc
3801721 ggcgatcagc gccgcgaccg cggcggccgc ggccccgacg atccaggttg ccgcggccgg
3801781 cgccgacgag gtgtcgctgg ccatctcggc gctgtttggc cagcacgccc aggcctatca
3801841 ggcgctcagc gcccaggcga cgatctttca cgaccagttc gtgcaggccc tgacctccgg
3801901 cggcaacctg tatgcggccg ccgagagcca caccgtcgag cagatggtgc tcaacgcgat
3801961 caacgcgccc acccagacac tgttcggccg cccgctgatc ggcgacggcg ccaacgggac
3802021 cgcggagaac ccggacggcc aaaacggcgg cctgctgttc ggcaacggcg gcaacggctt
3802081 tacccagacg accgccgggg tggccggcgg caacggcggc agcgcggggt tgatcggcaa
3802141 cggcggggcc ggcggcggcg gcggggccgg cgccgccggc ggcctcggcg gcaacggcgg
3802201 gtggctgtac ggcaacggcg gggccggcgg catcgggggc gcgggcaccg gaaccggtgg
3802261 tcacggcggg gccggcgggg ccggcggccg ggcctggctg tggggcaccg gcggggccgg
3802321 cggagccggc ggtgacggcg gctggttgtt cggcgacggc ggggccggcg gcaccggcgg
3802381 caacggcggc agcggcttta acagcttgac ctcttcggtc ggcggcgccg gcggggccgg
3802441 tgggcacgcc gggctgttcg gcgccggcgg gaccggcggg accggcggca tcggcgggca
3802501 aaacaccgag accggcccgg ccgccagcaa cggcggcgcg ggcggcgccg gtggcggcgg
3802561 cgggtacctg gtcggcgatg gcggcgccgg cgggaccggc ggggccggcg ggaagaattc
3802621 cagcggtggc gccaccctca ccgggggcac cggagggacc ggcggggccg gcggggcggc
3802681 cgggtggctc tacggcagcg gcggcgccgg cggtgccggc ggcgccggcg ggctcaacaa
3802741 cgccggtggt gccaccggcg gcaccggcgg taccggcgga gccggcggct ctggagcgtg
3802801 gctgtacggc aacggcgggg ccgccggggc cggcggcaac ggcggcaaca ataccagcgc
3802861 cggcaccggt ggtgtcgggg ctagcggcgg gaccggcgga aacgccgggc tgatcggcgc
3802921 cggcggccac ggcggggccg gcggcgccgg cggaaaccaa accggtggcg tgggcaacgg
3802981 cggggccggc gggaacggcg gcgccggcgg ggccggtggt cagctgtacg gcaacggcgg
3803041 ggacggcggc aacggcgggg ccggcggggc caacatcgcc ggcggcaatg gcagcgacgg
3803101 cggcgccgcc ggccacggcg gggccggcgg gagcgcccgg ctgatcggag ccggcggcca
3803161 cggcggggac ggcggcgccg gcgggaacac cgccggcaga agggccgacg cgatcgccgg
3803221 caccggcggg gacggcggca acggcgggaa tggcggcttg ctaagcggca acgccggggc
3803281 cggcggccac ggcggggcgg gcgggagcag caccgcgacc accaccaccg gaacaccccc
3803341 aacgggtgca acgggcggca atggcggcaa cggcggggcc ggcggcacgg ccgggtttac
3803401 cggcagcggc ggcatcggcg gcaacggcgg ggccggcggc accggcggta acgccggtgt
3803461 cgccttgtcg gttggcagca cgggcggact gggcggtaac ggcggcagcg ggggcctcgg
3803521 cggcggcggc gggtcgctct tcggcaatgg cggggccggc ggtgtcggcg caaccggcgg
3803581 aaacggcgga agcggtatcg ggcccgccag cgtgggtggc aacggcggca agggcggcgt
3803641 tggtgcggcc ggcgggcttg ccgggcagat cggcaacggc ggtagtggtg ggtccggcgg
3803701 tgccgggggc aacggcggga ccggcgatac cgccggcaac ggtggcaatg gtggtgccgg
3803761 cgcggtcggc ggcaacgccc agctcatcgg caacggcggc aacggcggtg gcggcgggaa
3803821 cggcggaacc ggcgccgacg gcacctaagg cccgcgagca gacgcaaaat cgcccaattt
3803881 cgtgccgaat tgggcgattt tgcgtctgct cggcgcagct aacccgccac gtactccacc
3803941 gcgccgtcgt cgagcaccac ccgggcctcg gcgccgtcgg agccggccac ctcggtgcgg
3804001 aacaccgccc ggcccggctc ggtgcgccag atcaccgtcg acagcgtctc gccgggaaac
3804061 accggcttgg tgaaccgcgc ggcgatcgag gtgatgttgg ccgccacacc gccgccaagc
3804121 tcggccacca gcgcccggcc cgccaccccg taggtgcaca acccgtgcag gatcggcttg
3804181 ggaaacccgg ccagctgcgt ggcgaaccag gggtcgctgt gcagcgggtt gcggtcaccg
3804241 gagagccggt agatcagcgc ctggtcctca cgggtcggca tatcgattcg ggcgtcgggg
3804301 tggcggtccg gaaattccgg cgcggccggc cgctcacccc gcgctcctcc gaaacccccc
3804361 tgaccccgaa gcaccaacgt ggtaagcgtt tcggcaacca acgaacccga ttccgggtcg
3804421 caaccgcggc cgcgcagcac aacgatggcg ttcttgccct cccccttgtc ctggatgtcg
3804481 gcgacctcgg tgaccaccga cagttttccc gccgccggca gcggcgcatg cagccggatg
3804541 ccctgggagc cgtgtagcag cgccgccggg ttgaatgttc ccacctttgc ggccgcacca
3804601 aacgccggac agcaaatcac cgcatacgtc ggcaacactt gctggtcgat gccgtggctg
3804661 ttctccgtgg tgaacgccag atctccggtc ccggcgccca ccccgatcgc gtaaagcagc
3804721 gtgtcccggt cggtccactc gaacaacatc ggctcggtca ctgcacctat ggagttcgga
3804781 tcaatcgcca tgcaactctc ctcccggttg gaaaatcatc gcaagccctt cccccggacg
3804841 gtatcgacag ggcaggctat cgccatggcg aagcgcaccc cggtccggaa ggcctgcaca
3804901 gttctagccg tgctcgccgc gacgctactc ctcggcgcct gcggcggtcc cacgcagcca
3804961 cgcagcatca ccttgacctt tatccgcaac gcgcaatccc aggccaacgc cgacgggatc
3805021 atcgacaccg acatgcccgg ttccggcctc agcgccgacg gcaaagcaga ggcgcagcag
3805081 gtcgcgcacc aggtttcccg cagagatgtc gacagcatct attcctcccc catggcggcc
3805141 gaccagcaga ccgccgggcc gttggccggc gaacttggca agcaagtcga gattcttccg
3805201 ggcctgcaag cgatcaacgc cggctggttc aacggcaaac ccgaatcaat ggccaactca
3805261 acatatatgc tggcaccggc agactggctg gccggcgatg ttcacaacac tattccgggg
3805321 tcgatcagcg gcaccgaatt caattcccag ttcagcgccg ccgtccgcaa gatctacgac
3805381 agcggccaca atacgccggt cgtgttctcg cagggggtag cgatcatgat ctggacgctg
3805441 atgaacgcac gaaactctag ggacagcctg ctgaccaccc atccactgcc caacatcggc
3805501 cgcgtggtga tcaccggcaa cccagtgacc ggctggaggc tggtggaatg ggacggcatc
3805561 cgtaacttca cctgaccgcg cggttgacgc ttaccgccgc tgaccgccac gattgaccgc
3805621 atgcggtacg tcgttaccgg cggtaccggg tttatcgggc gccacgtggt atcccgtctc
3805681 ctggacggcc gacccgaggc acggctgtgg gcgctggttc gccgccagtc gttaagccgc
3805741 ttcgagcgcc tcgccggcca gtggggtgac cgggtaagac cgctggtcgg tgatctcacg
3805801 gagctcgaac tgtccgagcg gaccatcgcc gagctaggcg atatcgacca tgtgctgcac
3805861 tgtgcggcgg tacacgacac cacctgggcc gacgccaccc gcgccgtcat cgagctggcg
3805921 gcacgccttg acgccacgtt tcatcacgtg tcgtcgatcg cggtggccgg agacttcgcc
3805981 ggccactaca ccgaggccga cttcgacgtc ggccagcgcc taccgacccc gtatcatcgg
3806041 atgacattcg aggccgaacg gctggtgcgc tccacgcccg gcctgcgcta tcgcatctac
3806101 cgcccggcgg tggtggtggg tgattcgcgc accggcgaga tggacacgat cgacggaccc
3806161 tactacttgt tcggggtgct ggccaagctg gcggtgttgc cgtcgttcac cccgatgctg
3806221 ctgccggaca ttgggcgcac caacatcgtg ccggtcgact atgtggccga cgcgctggtg
3806281 gcgctcatgc acgccgacgg ccgggatggg cagacgtttc atttgaccgc gccgacagca
3806341 atcggactgc gcggcatcta ccgcgggatc gccggcgcgg ccggactgcc cccgctactc
3806401 gggacgctgc ccggctttgt ggccgcaccg gtgctcaacg cgcgcggccg cgccaaggtg
3806461 ctgcgcaaca tggcggccac ccaactggga attcccgccg agattttcga cgtcgtcggc
3806521 tgcgcgccca cgttcacgtc cgacacaacc cgggaagcgt tgcgcggcac cggcattcac
3806581 gtccccgaat tcgccaccta cgcgcccggg ctgtggcggt attgggccga gcacctcgac
3806641 cccgaccgcg cgcgtcgcaa cgatccgctg ctgggccgcc acgtcatcat caccggtgcg
3806701 tccagcggca tcgggagggc atcggcgatc gccgtcgcca aacggggtgc gacggtattc
3806761 gcgctggccc gcaacggcaa cgcgctagat gagctggtca ccgagatccg cgcccatggc
3806821 ggtcaggcgc acgcattcac ctgcgacgtc accgattccg cgtcggtgga gcacaccgtc
3806881 aaggacatcc tgggccgttt cgaccacgtg gactacctgg tgaacaacgc cggccggtcg
3806941 atacgccgct cggtggtcaa ctccaccgac cggctgcacg actacgagcg ggtgatggcg
3807001 gtcaactact tcggcgcggt gcgcatggtg ctggcgctgc tgccgcattg gcgcgagcgc
3807061 cggttcggcc acgtcgtcaa cgtctccagc gccggcgtgc aggcccgcaa tcccaagtac
3807121 agctcgtatc tgcccaccaa ggccgcgctg gacgcgttcg ccgacgtggt cgcctccgag
3807181 acgctgtccg accacatcac gttcaccaac atccatatgc cgctggtggc caccccgatg
3807241 atcgtgccgt cgcggcggct caacccggtg cgcgcgatca gcgccgaacg cgcggcggcg
3807301 atggtgatcc gcggactcgt ggaaaagccg gcgcgcatcg acactccgtt gggtacgctc
3807361 gccgaagccg gcaactacgt cgcgccacgg ctgtcgcgcc gaattctgca ccagctctat
3807421 ctgggctatc ccgattcagc tgcagcgcag gggatttcgc gtccagacgc ggaccgccca
3807481 ccggcgccgc ggcgtccccg gcgatccgcc cgcgcgggag tcccgaggcc gctcaggcgc
3807541 ttggggcgac tggtgcccgg tgtgcattgg tagtcacttc tggcaggtga actggttgac
3807601 gtcgatgtat ccgatgcgaa acatctcggc gcagccggtg aggtacttca tataccgctc
3807661 gtagacttcc tcggattgca gcgcgatggc ctggcccttg ttggcctgca acgccgcgga
3807721 ccagaggtcg agggttttcg catagtgcgg ctgcaacgat tgaactctgg tgacggtgaa
3807781 gccgtttgcg ctggcacact cctgcaccat cggtatcgag ggcagccgcc cacccggaaa
3807841 gatctcggtc acaatgaatt tcaggaaacg agcgaaggtg aacgacatgg gcaggccgcg
3807901 ttcgtggatc tctttcggat gcaacccggt gatggtgtgc agcagcatga ccccgtcagc
3807961 gggcagcagg cgatgcgcca ggctgaagaa cgcgtcgtag cgctcgtgac cgaaatgttc
3808021 gaaagcaccg atgctgacga tgcggtcgac gggctcgtca aactgttccc agccggccag
3808081 cagaacgcgt ttggagcgta gattttcgga gttggcgacc agctgctgaa cgtggttggc
3808141 ctggtttttg ctcagggtca gaccgacgac gttgacgtcg tatttttcca ccgcgcgcat
3808201 catggtggcg ccccagccgc agccgacgtc caacagtgtc atgcccggct gcaatccgag
3808261 tttgcccagc gcgagatcga tcttggcgat ctgcgcctct tgcagcgtca tgtcgtcgcg
3808321 ctcgaagtag gcgcagctgt aggtctgagt gggatcgagg aacagccgga agaagtcgtc
3808381 ggacaggtcg tagtgcgcct gcacgttggc gaagtgcggc ttcagctcgt cgggcattgg
3808441 gatagcgtat cgtcgtcgcg gtgagcgtcg tattcgccga cgtcgacacc ggcatcgacg
3808501 acgcgctggc cgtgatctat ctgctggcca gtcccgacgc cgatctggtc ggcatcgcct
3808561 cgaccggcgg aaacatcgcg gtaggtcaag tgtgcgcgaa caacctgagc ttgctcgaat
3808621 tgtgcggtgc cgcagacatc cccgtgtcca aaggcgccga tgagccgctc ggcggccggt
3808681 ggcccgatca cccaaagttt cacggcccca aggggatagg ctatgccgag ctgccggcca
3808741 gcaatcgccg gctcaccgat tatgacgcca cgacggcctg gatcgcggcg gcgcactccc
3808801 acgccggcga cctgatcggt ctggtcaccg gcccgctgac caacctggcg ctggcgctgc
3808861 gcgccgaacc cgcgctgccg aggctgctgc gccggctggt gatcatgggc ggcatgttcg
3808921 acggccagcc gatcaccgaa tggaacatcc gggtggatcc cgaggcggcc agcgaggtgt
3808981 tcaccgcgtg ggccggacaa cgacaactgc cgatcgtgtg cggtttggat ctcacccggc
3809041 gggtcgcgat gacaccggac attctcgccc ggctggcgtc cgtctgcggc tcgtctccgg
3809101 tgatgcgggt gatcgaggac gcgctgcggt tctacttcga gtctcatgag gcgcgcggac
3809161 atgggtacct ggcatatatg cacgacccgc tggccgccgc ggtcgcaatg gacccggaac
3809221 tcctgacgac ccggaccgcg acggtggatg tcgacccgac gggggcgacg gtcaccgact
3809281 ggtccgggaa gcgaaatccc aacgcgcgga tcggcatgag cgtcgatccg gcggtgttct
3809341 tcgaccggtt cgtcgaacgg atcggacgat tcgcgcgccg aacgtgaact gacggcggga
3809401 ttttcccgaa attctcgccc tgacgtcacg ttcggcgcaa gtcattcgta gcttccctcc
3809461 agataccacc gccgctgccg gtagcacagc agcaacgcgg tgccgggatc gccgtccagc
3809521 aatacctgag cgcgcgcggt gcggccactc gcccgatccg gatcccacca ccgctcgtcg
3809581 tccggccacg gtccggccca ccagcgcagc cgatcgtctc ggccacgaac cctcagccgc
3809641 gccgggtccg cggagaacat cccccggctg gtcacccgta tcgggtttcc ttgggcgtca
3809701 agcaagtcca ccggatcgtc gaacagcacc gccggcgacg ggtcgggcaa cctgccgggc
3809761 cacggctgac cggggtcggc ctgcggcacc ggctcagggg ctactaggcc cagcacggtc
3809821 aacgtgatgc gttcggccgg gccgtgtccg ccggatagca ccggcacccg cacggcctcc
3809881 ggaccgagca agccctgcac ccgcaccagc gcccgacggg cccgaagcct gtcctgttca
3809941 ccgagcccgc cccatagcgg caactgcaag ccttccgatg cggacaccgt ctccaccgcc
3810001 tgcagccgca gcagagtcac cgccgcggtg ggccggtcac gagcattccg gttgttcaac
3810061 cacccgtcca gttgccagcg cacccggtcg gcggtggcgt cctcggtcag cggctcggcg
3810121 caccgccaca cccggctgcg ctcttcgccg ttggcggtga cggcatgaat ggccagccgg
3810181 gtgcagccca ctccggcggc catcagcgcc cgatgcagct cggcggccag cgagcgcccg
3810241 gcgaacgccg cggcgtcgac ccggtcgatc ggcggatcgc atgccagctc ggcggccaga
3810301 tccggcggcg gctcccgccc gcagggcgcc cgttccggtt cgccgcgggc gaaccggtgc
3810361 gcggccaccg cgtcggcacc gaacctggac gccacgtcgg tacgagacag cgcggcgaac
3810421 tgtccgatgg tgcgaatccc catcctccac aacagatccg tcaggtcgtc ccggcccggc
3810481 ccggacaggc tcggctcggt ggcaagttgg cggatcgaca gcagcgacag aaaccgcgca
3810541 tcgcctcccg gctccacgat gcggccagca cgcgcggcga aaaccgcggt agacaaccgg
3810601 tcggcgattc cgacctgaca ctccgcgccg gccgcggcca ccgcgtcgat cagccgctcg
3810661 gccgccatct gctcggaccc gaaaaaacgg gccggcccgc gcaccggcaa caccaggagc
3810721 ccgggccgca gcagctcggc gcggggcacc agatcgtcta ccgccgcgat caccccttcg
3810781 aagagccggg cgtcgcggtc ggcgtcggca gtcgctataa acagttgcgg acaccgcgcc
3810841 gccgcctccc gacgccgcaa ccctcggcgc accccggccg cccgcgcggt cgccgagcag
3810901 gcgatcaccc ggtttgccaa cgtgaccgcg accggggccg tcgcggatag gcccgcggcc
3810961 gcggccgccg cgaccgcggg ccagtccata caccagatcg ccagcacgcg agcggaggcc
3811021 atcaccgtcc acgcccgttg atctgcagcc gcaccccact gatccgcccc aaccccgggg
3811081 tgggcacgcc cctgagggcc ggggtgatct catagccgca gacccgggcc gcaagccgcg
3811141 tcgacacgcc ttgccagtcg ccgtcggtga ccagcagggt gcagcctttt tgacgggcac
3811201 gggccaccac tgcccgcgcc cgcgcccgcg tcacccggcg ccctcccaga ccgagcacca
3811261 ccagatccat gccgtcgatc agcacagcgg ccacctcaac cggatcggtc ccgggatctg
3811321 gtatcaccgc gagccggctc agatccgccc ccatctccac cgcggccagc aacccgatat
3811381 ccggctggcc aacgatggcc gcgtttcccc cggccgccgt caccgatgcc accatgctca
3811441 gcagcagtga ccgcgcaccc gacagcactc ccaccgtccc cgggggcaac gacaccggtc
3811501 ccgccggcac caggtcgccc gaacggctgg gccccccgga caccttctcg gacagcaaag
3811561 ccatctgccg tcgtagtgat tcgagctgct cagcaccatt ttcaaggcgt tggtcggagg
3811621 cgaaggccgc agtcatgacc agcctcctgt tcgaaaatat gttcgaagtc agtaaacacc
3811681 cgtccttgga gtccgtcaag gtcatgagag gctgccttgt gcaatcgcgt aaaaccacct
3811741 cggtactggc ggctgccctg ctgttttgcg gcctgttagg cccagggacg gccccaccgg
3811801 ccaccggtgg cgggcctgcc tgccggccgg cagagctctt cgccaccgac aacaccaccg
3811861 atgggttcga gctaccggcc gttgcgacta tcgcactaac cggcacggtg gtgaccggat
3811921 cgaccctggt cgacggcgtg ttctggtcga atgagcgcca gcagatcggc tacgagcgct
3811981 cccgtgaatt tcatctgtgc gttgtcgacg cgcccacatt gcacaacgcc gccgaggcac
3812041 tgcaccgcca gttcaaccaa gaagcggtgc tgaccttcga ctacttgccg cagaatgcac
3812101 ccgaggcgga cgcgatcctc atcaccgtgc ccgacatcgg catcgcccgc ttccgcgatg
3812161 ccttcgcatc tgatttggct gcacaccacc gattacgggg cggatctgtc accacagccg
3812221 accacacctt aatcctggtc gccggcaacg gcgatctcga tgtcgcccgc cgactcgtcg
3812281 aggaggccgg cggggactgg aacgcaacca ccattgccca tggcaggcgt gaattcgtga
3812341 actagctgat caagggcgct ccgctggcca cccgagccgg gttggtcaca ttagttagtc
3812401 acagcaatct ctgggccggc gggcacaacg cgtattcatc ccgacagata ccaatgtgtc
3812461 gcctgtgaca aaagccgggc ctggctaatg ctggccgccg ctactcccac tcgatggtgg
3812521 cgggcggctt gctggtgatg tccagcacca cgcggttgac ctcggcgacc tcgttggtga
3812581 tccgggtcga gatgcgctcg agcacctcgt agggcacccg ggtccagtcg gcggtcatcg
3812641 cgtcttcact cgacaccgga cgcagcacaa tcgggtggcc ataggtgcga ccgtcaccct
3812701 gcacacccac cgagcggaca tcggccaaca gcaccaccgg acactgccag atctggttgt
3812761 ccaggcccgc cgcggtcagc tcctcacgca cgatcgaatc ggcgtgccgc agcgtatcca
3812821 accgcttggc ggtgacctcc ccgacgatcc gaatacccaa ccccggtccc ggaaacggct
3812881 ggcgcgccac gatctcctcc ggcagaccca actcccgccc gaccgcgcgc acctcgtctt
3812941 tgaacagcag ccgcagcggc tcaacgaggg tgaacttcag gtcgtcgggc aggccgccga
3813001 cattgtggtg gctcttgatg ttcgcggtgc cgctgccccc gccggactcc accacatccg
3813061 gatacagcgt gccctgcacc aggaactcag cagtcttacc gtccagcaca tcccgcaccg
3813121 cgccctcgaa cgcgcggatg aactgacggc cgatgatctt gcgtttgccc tcgggggcgc
3813181 tcacgcccga cagcgcctcg aggaaggtct cggccgcgtc gacggtgacc aggttggcgc
3813241 cggtggcggc cacgaaatcg cgttgcacct gcgcccgctc accggcgcgc aacagcccgt
3813301 ggtcgacgaa gacacaggtc aaccggtcgc cgatggcccg ctgcaccagg gccgcggcca
3813361 ccgcggaatc cacgccgccg gatagcccgc agatggcgtg gccgtcgccg atctgggtgc
3813421 gcacctgctc gatcagcgcg ttggcgatgt tggcgggcgt ccactgggcg ccgagcccgg
3813481 cgaagtcgtg caaaaaccgg ctgagcacct gttgcccgtg tggggtgtgc atcacctccg
3813541 ggtgatactg caccccggcc aggcgccggt cgaaggcctc gaaggcggcc accggggcac
3813601 cggcgctgct agccaccacg tcgaatccgt ccggcgcggc cgtgaccgcg tcaccgtgac
3813661 tcatccatac cggctgaacc tcgggaagat ccgaatgcag tttgccacca aggactttca
3813721 gttcagtccg accgtattcg cgagtgccgg tgtgggcgac gatccccccg agcgcctgcg
3813781 ccatggcctg aaacccgtag cagatgccaa gaaccggtac accgaggtcc agtagcgccg
3813841 gatcgagttt cggagcgccg tcggcgtaga cactggccgg tccaccggaa agcacgagcg
3813901 ccaccggctg acgggccctg atctcctcga tcgaggcggt gtgcggaatc acctcggaga
3813961 aaacccgtgc ttctcgaacc cgacgggcaa tcaactgggc atattgggca ccgaagtcga
3814021 ccaccaacac cggtcgagcc ggtgtctcag gcacgtcgat gtcagcaggc tgcaccacgg
3814081 ccagtcagtc tagtggctgg ggtgactccc gaggtcggcc ggtagcggtc catgggccgg
3814141 tccgcaggtt accgaagagg ccagtgctgc cgccgccact tgggccttct tcagtcccga
3814201 cagagagatt cgccgatcgt agacgaccgc cggcgatgct ctgatcaagg cgagctgacg
3814261 gcggtagatg ccagacatgg ccgcacagca ggcagcgctg cggcggtcga ggtgtggaat
3814321 cagccgcagt cccagcgaat accagtctgc ggcgcggtcg gcactgaacc gcagcagtgc
3814381 cgcgagccgt ccgtcggggt catcgagtgc cccggtgtcg tccaggcgga ggcgtacgcc
3814441 taatcggtcc agctcgtcgc gcggcaggta gatccgtcca ttcaaaaagt cctctcgaac
3814501 gtcgcgcaga atattggttt gctgcagagc gattcccaac tgctcggcgt atcgcgacgt
3814561 cgccgtgctg acgggtccaa agatggaaag acaaagcttt ccgatcgtgc cggccccccg
3814621 gcggcagtag acgatcagct cgtcgaaatc gcggcaacca gtccagtcga tttccatacg
3814681 ggcgccgtca atcaactctg cgaacatcgc gatcggcacc ggaaaccggc gagccgcgtc
3814741 agccagcgca accagcaccg gatcggatga atcatcaata ttatcaagtg atttcctgat
3814801 ggcatcgagc tcggtgatct tggtctcggg ggccagctcg ccgtcggcga cgtcgtcgat
3814861 ccggcggccg agcgcataga ccgcagatag tgccgctcgc ttttcgcgcg gcaagagtcg
3814921 gatgccgtag tagaagtttc tggcggccgt gcgcgtgatc gactcggtga ttcgatacgc
3814981 ctgttcgatc tcggtcatgc cgtcctccaa ctacggtgtt ggtcagtcac gcctgacgat
3815041 cgacgatgta gtgagccaaa tcctgaagct cagcggccgg gcgatcggga atgccgatgc
3815101 gcgccaccat gtcgatgcct tgcgttacgt gtcggcgggc ctccgcgctt gcccacctgc
3815161 gccccccacc gcactcgatc agttctgcga ccgctgcgag ctcatcatcg gacgctgtct
3815221 ggctgcccgt ctcgtccacc agccacgctg cgaggcggcg gccggccgaa ccgccgtgcg
3815281 ccacggtcca ggtaacgggc agagttttct tgcgggagcg aaggtccgag tacaccggct
3815341 tgccggtgat ctcaggacgg ccccaaatgc cgagcaggtc gtcgaccaat tggaaggcaa
3815401 gtccaatgtg acgaccgtag gcaaccaacg cttctcgcac cgaacgcggt gcgccagcga
3815461 gtaacgcgcc gacctcggcg ctggctgcca tcagtgctgc ggtcttgcct tcagccatct
3815521 tgagacactc atcgagtgcg acgtcggttc ggctttcgaa cgcggtgtcg gcggcctgcc
3815581 cacggatcaa ctcacgggtg gcttccgaaa tcgcgcgcag cgccgcaccg acgtgtggtg
3815641 aatcgcaatc cagcaggacc tcgtgcgcca gcgacagcat cgcatcaccg gccaatagcg
3815701 ccatcgcatc gccccacagt gcccacaccg tcggccggtg ccgacggtgc tcgtcgcggt
3815761 ccatgaggtc gtcatggacg agcgagaagt tgtgcaccag ttcaaccgag acggctccgg
3815821 gaatcgccga gtgggggtcg gcgccggcgg cttcggcggc gacaaacacc aaagcaggac
3815881 ggattgcctt gccgcagttg ttgttcactg gacggccgcg ttcatcagac cagccgaggt
3815941 ggtaggacac gacgggccgc atgtggggat cgaggcggtc agccatctgg cgcagcgtcg
3816001 gtgtgatgag ttcgtgtgcg agtcccaaaa cgggaagcgt gcgacgggtc atacggtcgc
3816061 tgtcgggttg cggtggcagt ccgtactttt cgtcggtacc gcgcattgcg tgaatctagc
3816121 attcgctcat ggcacggccc atgggcaagt tgcccagcaa tacgcgaaaa tgtgcacaat
3816181 gtgcaatggc ggaggcacta ttggagatcg ctggtcagac tattaatcaa aaggaccttg
3816241 gcaggagcgg acggatgacg cgtaccgaca atgacacttg ggatctggcc tccagcgtgg
3816301 gggcgaccgc cacaatgatc gccaccgccc gggcgttggc tagcagggcc gaaaaccctt
3816361 tgatcaatga tccattcgcc gagccgctgg tgcgcgccgt cggcatcgac ctgtttaccc
3816421 ggctggccag cggcgagttg aggcttgagg acatcggcga ccacgccacc gggggtcggt
3816481 ggatgatcga caacatcgcg attcggacca agttctacga tgactttttc ggtgacgcaa
3816541 ccacggcggg tattcggcag gtagtgattc tggcggctgg gctcgacacc cgcgcgtacc
3816601 gactgccctg gcccccgggc acggtggtct acgagatcga ccagcccgca gtcatcaagt
3816661 tcaagacacg ggccctcgcc aatctgaacg ccgaacccaa cgcagaacgg cacgccgtgg
3816721 ccgtcgatct gcgaaacgat tggccgacgg cgctgaagaa cgccggcttc gacccggcca
3816781 gaccgacagc cttcagcgcc gaggggttgc tgagctacct gcccccacag gggcaggacc
3816841 gcctgctcga tgcgattacc gcgctcagcg cccctgacag ccggttggcc acccagagcc
3816901 cactggtgct cgacctggcc gaggaagatg agaagaagat gcgcatgaaa tccgcggccg
3816961 aggcatggcg ggaacgcggc tttgatctgg acttgaccga gctgatctac ttcgatcaac
3817021 gcaacgacgt ggccgactac ctcgccggct ccggctggca ggtcaccacc agcaccggca
3817081 aggaactctt tgcggcccaa gggctgccgc ccttcgcgga cgaccacata actcggttcg
3817141 ccgaccgccg ctacatcagc gcggtgctga agtaggtggc cccggcacta tagccgggcc
3817201 taactcgtag gcttggtacg cgggcagagc cgccaggcat ggcgaactgg tatcgcccga
3817261 actatccgga agtgaggtcc cgcgtgctgg gtctgcccga gaaggtgcgt gcttgcctgt
3817321 tcgacctcga cggtgtgctc accgataccg cgagcctgca taccaaggcg tggaaggcca
3817381 tgtttgacgc ctacctagcc gagcgagccg agcgcaccgg cgaaaaattc gttcccttcg
3817441 accctgccgc ggactatcac acgtatgtgg acggcaagaa acgcgaagac ggcgttcgat
3817501 cgtttctgag cagccgcgcc atcgaaatac ccgacggttc cccggatgac ccgggcgccg
3817561 ccgagacggt gtatggcctg ggcaaccgca agaacgacat gttgcacaag ctgctgcgcg
3817621 acgatggggc ccaggtgttc gacgggtcgc ggcgctacct ggaggcggtc acggccgcgg
3817681 gtctcggtgt ggccgtggtg tcttcgagcg ccaacacccg cgacgtgctc gcgaccaccg
3817741 gtctggaccg gttcgtccag cagcgggtgg acggcgtgac gttgcgcgaa gagcacatcg
3817801 ccggcaagcc ggcccccgac tccttcctgc gcgcggcaga actgttgggg gttacccccg
3817861 acgcggcggc ggtgttcgag gacgccctgt ccggggtggc ggccggccgc gccggcaact
3817921 tcgccgtagt ggtgggcatc aaccgaacgg gccgggcggc tcaggccgcc cagttgcgcc
3817981 gccatggcgc cgacgtggtg gtaaccgatc tcgccgagct gctgtagggc atgatcgggc
3818041 gatgatcacc gaggacgcct tccccgtcga accgtggcag gtccgcgaga ccaagctcaa
3818101 cctgaacctg ctggcccagt ccgaatccct attcgccttg tccaacgggc acattggatt
3818161 acgcggcaac ctcgacgagg gcgaaccctt cggactgccg ggcacctacc tgaactcttt
3818221 ctacgaaatc cggccgctgc cgtacgccga ggccggttat ggatatccgg aggccggcca
3818281 gaccgttgtc gacgtcacca acggcaagat ctttcgcctg ttggtcggcg acgagccgtt
3818341 cgacgtccgg tatggcgaat tgatctccca cgaacggatc ctcgacctgc gcgccgggac
3818401 gctgacccgc cgcgcgcact ggcgctcacc ggcgggcaag caagtcaaag tgacgtccac
3818461 ccggctggtg tcgctggccc accgcagcgt cgcggcgatc gagtacgtcg tcgaggcaat
3818521 cgaggaattc gttcgcgtga ccgtgcagtc cgaactcgtc accaacgagg acgtaccgga
3818581 gacctcggcc gacccgcggg tgtcggccat cctggacagg ccgctacagg ccgtcgagca
3818641 cgaacgcacc gagcggggtg cacttctcat gcaccgcacc cgagccagcg cgctgatgat
3818701 ggccgcaggg atggaacacg aggtcgaggt tcccgggcgg gtcgagatca ccaccgacgc
3818761 ccgcccggac ctggcccgaa ccaccgtgat ctgcgggctg cgcccgggac agaagctgcg
3818821 catcgtcaaa tacctggcct atggctggtc cagcctgcgc tcccgcccgg cgctgcgcga
3818881 ccaggccgcc ggcgcgctgc acggtgcccg ctacagcggc tggcaggggc tgctggacgc
3818941 gcaacgcgcc tacctcgacg acttctggga cagcgcggac gtggaggtcg agggcgaccc
3819001 ggaatgtcag caagcggtgc gtttcgggtt atttcacctg ttgcaggcca gcgcgcgcgc
3819061 cgaacgccgc gcgatcccca gcaaggggct caccggaacc gggtatgacg gccacgcctt
3819121 ttgggacacc gaaggtttcg tgctaccggt gctcacctac accgcaccgc atgcggtcgc
3819181 cgacgcgctg cggtggcggg cgtcgacgtt ggacctggcc aaggagcggg cggccgagct
3819241 cggcctggaa ggtgccgcct ttccctggcg gaccatccgc ggacaggagt cctcggccta
3819301 ctggccggcc ggcacggcgg cctggcacat caacgccgac atcgcgatgg cgttcgagcg
3819361 gtaccgcatc gtcaccggcg acggttcgct ggaggaggaa tgcggccttg cggtgctgat
3819421 cgagaccgcc cggctgtggc tctcgctcgg gcaccacgac cgccacggcg tctggcacct
3819481 cgacggggtc accggtcccg acgagtacac ggcggtcgtc cgcgacaacg tgttcacgaa
3819541 tctgatggcg gcgcacaatc tgcacaccgc cgccgatgct tgcttgcgcc accccgaggc
3819601 ggcggaggcc atgggtgtca ccaccgagga gatggccgcc tggcgcgacg cggccgacgc
3819661 cgccaacatt ccctacgacg aggaactcgg tgtccaccag cagtgtgaag ggttcaccac
3819721 ccttgcggag tgggatttcg aagccaacac cacttatccg ttgctactgc acgaggccta
3819781 cgtgcgcttg tatcccgcac aggtgatcaa gcaggccgac ctggtgctgg cgatgcagtg
3819841 gcagagtcac gcgttcacgc ccgagcagaa ggcgcgcaac gtcgactact acgaacggcg
3819901 catggtgcgc gactcgtcgt tgtcggcctg cactcaggcg gtgatgtgcg ccgaggtcgg
3819961 ccatctcgag ttggcccacg actatgccta cgaagccgcc ctgatcgacc tgcgcgacct
3820021 gcaccgcaac acccgtgacg gcctacacat ggcttcgctg gccggagcct ggacggcgct
3820081 ggtcgtaggc ttcggcggcc tacgcgacga cgagggcatc ctgtccatcg atccgcagct
3820141 gcccgacggc atctcgcggc tgcggttccg gctgcgatgg cgcggcttcc ggctgatcgt
3820201 cgacgccaac cacaccgacg tcaccttcat ccttggcgac ggtcccggca cccagctgac
3820261 catgcgccac gccggccaag atctgacgct gcacacggac acaccgtcca ccatcgccgt
3820321 gcgcacccgt aagccgctgc tgccgccacc accgcagccg ccaggccgcg agccagtgca
3820381 ccgccgggct ttagcccggt gacgatacgg gccgcgtagc ggcccgagga ggagccgggc
3820441 aatcggctta gcccggtgac gatgcgggcc gcgtagcggc ccgaggagga gccgggcaat
3820501 ccagcctgag cccggtgacg atgcgggccg cgtagcggcc cgagaaggag ccgggcaatc
3820561 ggcttagccc ggtgacgatg cgggccgcgc tgggggcacc atccgcttgc ggggacgcgt
3820621 ctgcgtctac ctgggcggca ccggtgaacg tctcattcac cgcgcacctc cgcttcctgc
3820681 acggcggcga cgacccgggc aacgtcatcc ggggccatgt ggtcgtggac tggcagcgac
3820741 acgattcgcg agcaaatgtc cgccgtgacg gctagatcgg tcgactcgac taactcggca
3820801 ttcgtcacaa agtacggatg tcggtgctgc ggtgggttgt agtagtcgcg cgcctcgatc
3820861 gcgtgcctac gcaggctacc cagaaccgcg gccttgtggt cggcggacgt gcagcaagcg
3820921 ctcgcgaaac agagcgacgc aacattggcg ttgtcctgga aacgcacacc cgcgtcggcc
3820981 ataccggtgc gatagcactc gaggaccttg cggcgacttg ccaggcggcg atcaagcccg
3821041 actagttggc gtaggccaat agcggcgctg atctccgaca gcttgccgtt cattccgagc
3821101 tggatggact cgcgtgtttg caccaagccg aagttctgga acttgtatgc gtgctcgacg
3821161 agccgtggat cgcgagaaac cagagcgccg ccctcaccaa ccgcgaacgg cttggtcgca
3821221 tggaaggaga agatctcgca tgcaccgcgt ccaccgaggc gctcgccgtc ggcgtacgtg
3821281 gagccgaagc cggccgccga gtcgagcaca atcggtagct cccattcggc ggcgagctcc
3821341 tcccagacgc tgatctgggg attgccgacg ccgaacacat tggccagcag gatgccggcg
3821401 atccggtcgc ggaagcgttc gatgacggcg cgggcggagt ggacgcatgg ctgccatgtg
3821461 ttggcgtcga tgtcgatgaa ccagggacgg tacccagtcc atagcgcagc ctgagccacg
3821521 ccgacgaacg tgaacgacgg catcagcagg tagcggtccc gcgtaccggc gccgaaactg
3821581 acgtggagcg ccgcgaggag tgccagggtg ccgttggcga gggtagcaac gtgcagatga
3821641 ggtcccagat agtcgcgcag ggcgcgggca aaccgccgct cgttcggacc gaagttcgtg
3821701 taccagttag cctgggcgat ctgtacgaag tcctcggcga gctcggctgg cccgggaaag
3821761 ctcgggcgga tgaaggggat cttggggatc gtcgagccac ccggctcgag ttttaacatg
3821821 gacgtgcctg gggtcgcgcg tactgcggac ggcggctcca gcaccgagcc ggataacgtt
3821881 cggatcttca tatatgcaga gctcaaggtc cgtttgcagc gcgtcgggac agtttccgca
3821941 gcgcacttcg tcgcaccatc gttggcatcg gcgcctgaag cagttaccgc gagaaccgca
3822001 tcatgtcgaa cttgaggtta gccttacctc ttaagaatgt cacccccggg gagtgacccc
3822061 ggctgtccac gcgtgggcga cccggcacgc acggtgcacg ttccctggtg tctcacccgc
3822121 ctcattcgtc ccggcgccac agggctagcg atatggccgc ctcgcgtagt cggtccgggt
3822181 cggtacgcgt ggggcagatg aggaaggtgc ggcgcattga agcagcctgt caagcccggc
3822241 tcggtgaccg gcacggcgcg ttcagcatgg ggccagtgcg acgggctgga gcgaagcaag
3822301 caggctggcc gccagcgatt tcgccagcga ccggacgcgc ggtgcgctct cgacgtgcca
3822361 aaaacggatc ttgggagtga aattgccgcc gactaggggc ccgatgacgc aaaaacctgg
3822421 gctggcctcg aagtcgtcgt taaccagaag gccacggttg gtgcggttcg ggcggcacag
3822481 cccgttctgc atcgcgctga ccaggaacgg cgaggaacac gtgtccagct cctcgaaacc
3822541 gccacaattc accaccgcag cgaaggggac ggggtgggta tgctcggctc ccgcggctcg
3822601 gtaggtcatg gtggcgaacg gctggccgga cgcgcaggca tccacgcgca gtacttcgcc
3822661 ggcgagcagg ctcagcgtgc cgtccgcggc tagctcctcg gatgcctggc ggcaatcgcg
3822721 tcccgcacgc cgcaccaact tggtgaagtt catgccgtgc acgcagaaga actcttcctg
3822781 ctgcacgaga tccatcttgt gcagcgcctg cccaaacagg gcggcaacgg cgtcgtacaa
3822841 atcggccagg ttcaacgagc gttcttcggc cgtcgcgaga tcgtcgcgga tcgcggacat
3822901 gagatccgcc gcggcgatcg cttccgtaca gagcagcgtg cgcagccgcg ggaagtcaaa
3822961 ctccggcggc tgattgcaga tcatgtaggg cagcacgccg gagcgcgaga tgacggtgat
3823021 ggaccggacg cgtgcgcgga tgcgcgcgtc gtgacgcatt aggtagagcg cttccagcga
3823081 ggtggcgttg gaacccacga ccagtacgtt gcgcttctcc cacgactcga cgcggtcgag
3823141 cgaatcgcgc agtcgcgcaa cgttgctctc cccgccgggg gagtagaaat cgttgatata
3823201 ggtgaatgcg ggttcggaat cgctcgcaag gatggctttg gtcggggggc tgccaatggc
3823261 cacaaccact ttgcctgcag caattgccgt tggaccgttt ccagacgggc ggaggccgat
3823321 tcggtagtgg ccgtctgcgg agtgggcgct catggcctca gcgcggatgg tgacgatttc
3823381 ggccaggtca cgctcgccga gcgcggcgat ggcggcaatc atctgctccg acagaaatac
3823441 accgaagaga aaccgcggca ggtagagctc cccccactgg ttgccgtcca atgcgtcgcg
3823501 gttgtcgcag atccagcggg ccgcggccgc accgccctct gcctggaaga acgccagcca
3823561 gcgctgcttg ttctgctcca gccagatccg gtaggcggcc ttttccggct cgtcggcgaa
3823621 atcgtcgagc ttctgaatgg ccagcgatcc gatgctggag cgttggccat aggggattcc
3823681 gcaccagaac tgctcgtctc gctccaccac cgcgatgcgc aacttgggcg atgccgaggg
3823741 gctgctcagc agggcatcgg ccatttccag cagagtcata gagcacgcgg ccccgctgcc
3823801 gatgaacgca acgtcgaagg taggtggagt gatcatagtc atcaaataag ggaaggctaa
3823861 cataacctcg aggcggtggt taggcttccg cgggcttctc cggttcgagc acgacgcgga
3823921 caaacacctt gcggcctgac gcatcgacga accaagcgtt gcggaaatca tcatgggtca
3823981 acgcgcgcag gcgattcagg aaatgcccaa acgttccgcg ctcgttcagg tctagccgcc
3824041 ggagttgttc gaaatccttt ttcaggttga ggttgccctc ggtggccggc gatttagccg
3824101 tgtagctgcc gtcccggatg gcgtcgaaat gttccagcac caactcacgc tcgatgtcca
3824161 tcagccgggc gtagacactt cccgaggaat cccacgactc gatcgcgcat tcccgctggg
3824221 cgatgatcgg accatggtcc aactgatcgt cgatctcgtg gatcgtcacg ccgacttttt
3824281 gcccgtcgat gatcgagaag acctggggaa accagccgcg gttgtagggg ttgaaacccg
3824341 gatgaacatt cacacacctg accccatcga tcaaagcggc gggaaacctc tgtttacagt
3824401 ggaaggaaag gacgaggtca taccgctcca cgatttccgc gacgcgctct gcgacatcac
3824461 atcgcgggac acccggcagc tggccgatgg gggactgata gacgtccata tcgccatgcc
3824521 tggcctgcag atcgaccgcc agagcatggg cgtggacgtt gtcggtcagg atcaatatcg
3824581 tcacgactcg cccccgccag cctgcccagc gcccatcagc ggagccccca acaccagctc
3824641 accctacttc agggccgacg cataccggac ggccacgctg gggccagcgc agggacatca
3824701 gtcagtgcgg ttccaggatc cgggctaccg catcgttcac ggacagccgt agttcgtcac
3824761 cggtcagctc gtcgataccc gtcgccgagc gcagcatggg cgcaaagagc cgccaaccga
3824821 attgcagcgc aagggcgtgc gcgaccgcca gccgcgcgcc caagtcgctg tcgtagcgag
3824881 gccgtaccgc gtcgagcagc tccgcaacat tgggaaatcg ctgttgcagc tggcccacgg
3824941 gatatccgtc cagcagtgcc cgggctaaga cccgcccatg tcggtcgaga gcccgttcga
3825001 tgatgtcagc gggcgcctcg gagtgcaaca gtctggtcag cttcgtgccc aggtgatcga
3825061 gcacggcccc aaccagttgg tccttggtgc cgaagtgacg aaacaccagc ccgtggttga
3825121 ccttggatcg agcggcgatg tcgcgaatcg acgtcgcggc tggcccacgc tcggcgaaca
3825181 ggtcggtggc ggcctgcagg attgcggccg ctacctcttc ccgcccagtg ggcatcttgc
3825241 ggcggtcggt tgccggacgc gtagtcatcc ggctacagta accgatgtag tcatctgact
3825301 acactaacca ttcattgagg acgccagcaa tgacagatct gattaccgtg aagaagctgg
3825361 gcagccgtat cggcgcccaa atcgacgggg tgcgcctcgg aggcgatctg gaccccgccg
3825421 cagtcaacga gattcgcgcg gcactactgg cccacaaggt ggtcttcttc cgcggtcagc
3825481 accaactcga tgacgccgag cagctggcgt ttgccgggtt actgggcacc ccgatcggcc
3825541 acccggccgc gatcgccctc gccgacgatg caccgatcat cacgccgatc aactccgagt
3825601 tcggcaaggc gaaccgctgg cacaccgacg tcacgttcgc cgccaactat ccggccgcct
3825661 cggtactgcg cgcggtctcc ctgcccagct atggcgggtc gacgttgtgg gccaacaccg
3825721 ccgcggccta cgcggagctg cccgagccgc tcaagtgcct caccgaaaac ctgtgggcgc
3825781 tgcacaccaa ccgctatgac tacgtcacga ccaaaccgct gaccgcggcg cagcgggcct
3825841 tccgtcaggt gttcgagaag ccggacttcc gcaccgagca tcccgtggtg cgggtacacc
3825901 cggagaccgg tgagcgcacg ctgctagcgg gcgacttcgt gcgcagcttc gtcgggttgg
3825961 acagccacga atcaagggtg ttattcgaag tgctgcaacg gcgaatcacc atgcccgaaa
3826021 acaccatccg ctggaactgg gcgccgggcg acgtagccat ctgggacaac cgggccaccc
3826081 aacaccgggc gatcgacgac tacgacgacc agcaccggct gatgcaccgg gtcaccttga
3826141 tgggcgacgt gcccgtcgac gtgtacgggc aggctagccg ggtgatcagc ggggcgccga
3826201 tggagatcgc tggctgatca accagtaagc gcaacgcaat tatgtagcac catgcgtgct
3826261 accgttgggc ttgtggaggc aatcggaatc cgagaactaa gacagcacgc atcgcgatac
3826321 ctcgcccggg ttgaagccgg cgaggaactt ggcgtcacca acaaaggaag acttgtggcc
3826381 cgactcatcc cggtgcaggc cgcggagcgt tctcgcgaag ccctgattga atcaggtgtc
3826441 ctgattccgg ctcgtcgtcc acaaaacctt ctcgacgtca ccgccgaacc ggcgcgcggc
3826501 cgcaagcgca ccctgtccga tgttctcaac gaaatgcgcg acgagcagtg atctatatgg
3826561 acacctcggc cctgactaag ctgctcatct ccgagcccga gacgaccgaa ctgcggacat
3826621 ggctgaccgc gcaaagcggc cagggcgagg acgcggcgac aagcaccctt ggccgggtcg
3826681 agtcgatgag agtcgttgcc cgatacggac aaccaggcca aactgagcgt gcgcgttacc
3826741 tactcgacgg gctcgacatc ctcccgctca ccgaaccggt gatcggtcta gctgaaacga
3826801 tcggaccggc caccctacgt tctctcgacg cgattcacct cgcggccgca gcccagatca
3826861 agcgggaact gacagccttc gtcacctacg accaccgatt gttgagcgga tgccgtgagg
3826921 tcggcttcgt caccgcctca cccggcgcag tccggtgacc atatccaacg accgcacgct
3826981 tcctgatgcc tcagcccgcg ttgctgaccg gatcgatcgg caaccaccgc agcgcgcccg
3827041 gggcgtcggc aggcaccacc gggtgcgccg gttggatcgg cgccagccga cgatagggct
3827101 caccctgcgg tggccgccgg tcggtttcgc ccttgttcgg ccacagcgag gcggcccgct
3827161 cggcttgagc ggcgatggac agcgacgggt tgacacccag gttcgccgag atcgccgcac
3827221 cgtcaaccac gtacagcgtc ggatagccat agacccggtg ataggggtcg atgacgccgt
3827281 gctcggggtc gtcgccgatc accgcgccgc cgagaaagtg cgcggtgagc gggatgttga
3827341 acagctcacc ccaggtgccg ccggccacgc cgtcgatttt ggcggcgatg cgacgggtga
3827401 cctggttgcc gatcgggatc catgtagggt tcggctcgcc gtgtccctgc ttgctcgagt
3827461 accagcggat acccagcttc ccgcgcttgg tgaacgtggt gatcgagttg tccaggtgct
3827521 gcatgaccag cgcgatcacg gtgcgctcgc tccattgccg gggattgagc atccggatgg
3827581 tgccgcgcgg atcctgactg gcggtctgca gcaactgcct ccagcgcggc acatcggtgc
3827641 cctgcggacc ggagccgtcg gtcatcaagg tctgcagcag ccccatcgcg ttggagcctt
3827701 tgccgtagcg cacgggttcg atgtgggtgt cggccgtcgg gtgaatcgac gacgtgatcg
3827761 ccacgccgtg ggtcaggtcc aggtccggat tgaccttcaa ggtggcggcc ccgacgatcg
3827821 attctgagtt ggtgcgggta aggacaccca atcgcttcga gagaccaggg agccgacccc
3827881 tatcccgcat cttgaacagc agatgctggg tcccccaggt gcccgcggcc agcaccagct
3827941 gcgttgcggt gaaggtgcgc cgatcccggc gcagccaact gccggttcgc actgtgcgga
3828001 cctcccacaa cccgtcggac cgccgctcaa accccttcac cgtggtcatc ggaatcactt
3828061 gcgcgccagc tgattccgcg aggccaaggt agtttttcac cagggtgttc ttggcaccgt
3828121 ggcgacagcc cgtcatacag cagccgcatt ccaggcagcc ggtgcgcgcc ggcccggcac
3828181 cgccgaagta gggatcgggc acggtcttgc cgggcgtctt ggtgccgtcg gggccgaaga
3828241 acactccaac cggggtcggc acccaggtgt cgccaaaccc catctcgtcg gcgacctcct
3828301 tgacgatgcg gtcggcgtcg gtgaaggtcg ggttttgcac caccccgagc atccgctgcg
3828361 cctgctggta gtgcggcatc agctcgccac gccagtcggt gatgtgtgac cactgctggt
3828421 cggcgaagaa cggctccggc ggcacgtaca acgtgttggc gtagttgagg gagcccccgc
3828481 ccaccccggc gccggccagg atcatcacgt tgcgcagcgg gtggatacgt tgaatgccat
3828541 agcagcccaa cctcggcgcc cagagaaact tgcgcaggtc ccacgacgtc ttggcgaact
3828601 cctcgtcgga gaaccggcgg ccggcctcca gcacgccgac ccggtagccc ttttccgtca
3828661 gccgcagcgc ggtgacgctg cccccgaaac ccgatccaat aatcaggacg tcgtaatccg
3828721 gcttcatcgc tgcagtatga ccccctttac atcgggccag ttaatcagtc tctcaggtgg
3828781 cgtcagcccc caacggtcag gccgaccttc tggaactcct tgaggtcgca atacccggcc
3828841 ttggccatcg atcggcgtag cccaccgacc agattcaggc cgccgaacgg gtcgtccgac
3828901 ggcccgccca gcacccgcgc cagcggcggc cgctcgccga ccgcgatctg cagcaacgcc
3828961 ccccgcggca acgacgggtg cgccgccgcg gccggccaga accatccctc gccgagcgcc
3829021 tcggccgatt cggctaacgg ggtacccagc accaccgcgt cggcgccgca ggcgatggcc
3829081 ttggccaact cgccggaagt gtggatgtcg ccgtcggcca acacgtgcac gtagcggccg
3829141 cccgtctcgt cgaggtagtc gcgccgcgcg gcggcagcgt cggcgatcgc ggtcgccatc
3829201 ggcacgctga tgcccagcac ctcgtcggtc gtcgtcaccc cctgggtgga gccgtagcca
3829261 acgatgacgc cggcggcgcc ggtgcgcatc agatgcagcg cggtgcggtg gtcgagcacc
3829321 ccgccggcga cgaccggtat gtcgagctcg gagatgaagg tcttcaggtt gagcggctcg
3829381 ccgtcgctgg cgacgcgctc ggcggagacg atggtcccct ggatgaccag caagtcaata
3829441 ccggccgcaa ccagtaccgg tgtcagccac tgggcgtttt gcgggctcac ccgcaccgcg
3829501 gtggtcaccc cggcctcgcg gatgcgagcc accgcggcac ccaacaggtc gggatttagc
3829561 ggtgccgcgt gcagctcctg cagcaaccgg atcgccgtcg acggttcggg gtcggccgct
3829621 gcagcttcca agagttgggc gatttttgcc tcgacatcga ggtggcggcc gatcagcccc
3829681 tcgccgttga gcacgcccag cccgcccagc cggccgagct cgatcgcgaa ctccggggac
3829741 accagggcat cggtggggtg tgccaccact gggatctcga accggtaggc gtccagctgc
3829801 caggccgtgg agacgtcctt cgacgagcgg gtgcgccgcg acggcacgat gctaatctcg
3829861 ctgagttcat aggtgcggcg ggcggtgcgg cccatgccga tctcgaccat ctagatatcc
3829921 aggtcgccgt tagcgcgcgt agtagttggg cgcctcgacg gtcatcgcga cgtcgtgggg
3829981 atgactctcc ttgaggcccg cgggtgtgat ccggacgaat tgcgcctgct gtagcacctc
3830041 gatggtgggc gacccggtgt agcccatcgc ggcgcgcagg ccaccggtca actggtggat
3830101 caccgacgac agcggaccac ggaacggcac ccgcccctcg atcccttccg gcaccagttt
3830161 gtcttccgac agcgcgtcgt cggcgaagta gcgatccttg gaatacgacg tcgccccccc
3830221 acgccctcgc atggcaccca gtgatcccat gccgcgataa ctcttgtact gcttgccgtt
3830281 cacgaagatc agctcaccgg gcgcctcggc tgtgccggcc agcagcgagc ccagcatggc
3830341 cgtcgacgca ccggcggcca gcgccttggc gatgtcgccg gagtactgca gtccgccgtc
3830401 ggcgatcacc ggcacgccag caggacgaca agccgctaca gcttccaaga tcgccgtgat
3830461 ctgcggcgcg cccaccccgg ccaccaccct cgtcgtgcag atcgaccccg gccccacgcc
3830521 gactttcacc gcgtcggctc cggcgtcgac cagggccgcg gccgcggacc tggtggcgac
3830581 gttgccgcct accacctcaa cccggtcgcc gacttcggac ttgagtttgc ccaccatgtc
3830641 gagcaccaac cggttgtgcg cgtgcgcggt gtccacgacc agcacgtcga ccccagcgtc
3830701 gaccaacatc atggcgcgca cccaggcatc gccgccgacg ccgacggccg cccccaccag
3830761 cagccggccg tcgctgtcct tggtggccag cgggtgttgc tcggtcttga cgaagtcctt
3830821 gacggtgatc agcccggtca gccggccgcg gccgtcgacc acgggcagct tctcgatctt
3830881 gttgcggcgc aacaggccca gcgccgcgga cgcactgaca ccctcttgag cggtgatcag
3830941 cggggctttg gtcatcacct cggcgacctg cttggactgg tcgacctcaa accgcatgtc
3831001 acggttggtg atgatgccca ccagcgcacc gtcgtcgtcg accaccggca acccggagat
3831061 ccggaaccgg gcgcacagcg catcgacctg ggccaaggtg ttgtccggcc ggcaggtgac
3831121 gggatcggtg accatgccgg cctcggatcg cttcaccatc tcgacctggc cggcttgctc
3831181 ggcaacgggc aggttgcggt gcaacacccc catgccaccc gcccgtgcca tcgcgatggc
3831241 catacgcgac tcggtgacgg tgtccatcgc cgagctgacc agtggcacct tgagcctgat
3831301 cttcttggtg agctggctgg aggtatccgc ggtggcgggc accacgtcgg aagccgccgg
3831361 caacaacaag acgtcgtcga atgtcagccc cagcatcgcc accttgtgcg ggtcgtcgcc
3831421 gccggtgggc accgggtcag tagtcaggcc gcccatgcga acgtacgggc tgaccaccag
3831481 gtcggagctg tcttccaggc cggacatgcc acgggacatc ggtggggccc tccatacgca
3831541 tgttttcagt gagaagccca tcctatcggc tcgtaaccgc ccggtgacga tgcgcgccgc
3831601 agcgctggcc gagaagaacc ggacaatcac accgcgacga ggctgcgcca gcgtgtggtc
3831661 agcccgacac gaagcgagaa ctcaatttct ggcgttatca ccgcgtgctt gcgtagtgta
3831721 gaggggtgcg cgaccacctg ccgccgggtt tgccgcccga tccgtttgcc gacgacccct
3831781 gtgacccgtc ggccgcactg gaggcagtcg agcctggcca gcccctcgat caacaagagc
3831841 ggatggccgt cgaggccgac ttggccgatc tggccgtata cgaagctctg ttggcgcaca
3831901 agggaattcg tggacttgta gtgtgctgcg acgagtgcca gcaagaccac tatcacgact
3831961 gggacatgct gcgttccaat ctgttgcaac tgcttatcga cggcaccgtc cgcccgcacg
3832021 agccggccta cgatcccgaa ccggactcct acgtcacctg ggattactgc cggggatatg
3832081 ccgatgcttc gctcaacgag gcagcaccag acgcggacag gttccgccgc cgctgatcgc
3832141 gctcgctagt gcgtcggact caccggcgtt tccggtgctg gctgccccgc cggattcgtc
3832201 gcctcgtcgg cgggttccaa cgaggggtca attgagcccg gctcgggttt tgatgacggc
3832261 gtgctggggc tggctgccac cgtggacgtg gagttcggca tggggctctc cgagacgcct
3832321 gccgacatcg acggttcagc tgccgatgca ggcgtcgggg gggtcggcgg ctcgacgact
3832381 ggagccagcg gagtccacga gtttcccacc gaacccggag ccgcagggtt ggacggcgag
3832441 ccgggccgca gcgtggcgtt cgggtcgcgc gtctccacct tggtattcag caggttcacc
3832501 tcgttgatca ggtcctgccg gcggctaccg tcagtcacgg cctgcacggt gctgctgacc
3832561 tcagccagct catcctgcgc ctcggcccat tggccttggg caatcatttg ctcgaccttc
3832621 gccagattgg ccttggccga cagcacgatc tgatcgtcgc tgacccgcga tcggttgaac
3832681 atcatcgcgt gcaggccgta caacaggtcc ccggggcgag catcggccac cacggcgccg
3832741 aacccgctca gcaccaacag cgccgcggcc accgacccga cggccgccag gctgcgacga
3832801 gcccgtcgcc gttgcgctac cccggcgcgc aacgcggcga cggcctcgtc ctgtgaaacc
3832861 agggcactgg ccggcggcca cctcaagtcg tcgcgccact gtccgagcag ggcggccaac
3832921 gcgtcatcgc gaggatccgc gaagtcaacc tcctcccgtt cggcgagtgc gtcgagcagc
3832981 agatcggtgc gggccagctc atccaatggc ggccgatcgc caaggggatt accaaattca
3833041 cgcatagtca cctgccgcaa caatctcgtc cttcagccgc tgaagtgcac ggtgttgggc
3833101 cacccggacc gcccccgtgg tgctgccgac ggcggcggcg gtctcttccg cggacaggcc
3833161 gacgacaaca cgcagaatga ggatctcgcg ttgcttggcc ggcaagatct caagcaattc
3833221 gttcatccgg gtgaccgaat cggcctcgat ggccatctgc tccgggccgg cgtcggctga
3833281 ccagcgctca ggaagcgttt cggcgggata ggcccggtca cggccggctg cccgatgggc
3833341 gtcggcaacc ttgtgcgccg cgatgccgta cagaaacgcc aggaatggcc ggccgcggtc
3833401 ccgatagcgc ggcagcgccg ttatggtggc caagcacacc tcctgtgcca cgtcatctgc
3833461 tgacaggccg ctccgctcga ccgtgccgac tcgcgctcgg caatatcgca cgacgatcgg
3833521 gcggatggtc tccagcacct cccgaagcgc gttccggtct cctgccacgg cctccgcaac
3833581 cacagcgtcg agacgttccc cttgcattgt catcgacggc gatatctcca acgttacgaa
3833641 gcggacacat cccgggctaa ctcccggatc gaccataacg gcccaaccgc gttttaagcg
3833701 gtacgccagc atccaccggc gcgccgcacc tggcctgcgc aaatattgcg tattttggtg
3833761 agttcgcgca gctgttgtgc tgaaaacgtg acggtgccga tatcgatcag caagcatgcc
3833821 agcgcccacc gcagcggcaa gagcccaaac cgggcggtgg catcgagagc ctcttcaccg
3833881 acggcgcgtg ctcgcgcgac ggcgccagca ctgcacagcg cggcggccaa caccacgtcg
3833941 cttttgacgc ggtggcgcgc cgacgcgacg gccatggcct gcgtcagctc gaccgcttcc
3834001 tcggcatggc ggacagcagt tgcgccgtcg ccggtggcca tcgccaactc ggcggccacc
3834061 caccgccgac gcaccgccag gcggtccgcc acgagcgggg acaccaccaa cggatccgcg
3834121 cgatctaaca atgcccccgc ggcggcgaag cggccgacgc caagcgcatc ggccgccagc
3834181 ccgatcagtg catcggcacc agcttcccga tcggcgccgg ccaacgccaa ggcacgacca
3834241 tcccagccgc gcgccagcgt gtgccaacca agctgccgca acaacgatcc ctgcgtacta
3834301 tgcgccagcg atgccaacgg gcccgccggc accaggcgtc gcagcaccga caggtcgcca
3834361 taggcgtggg cgtaacgacc ctgcccacca gcggccacgg cgcgcaacca caagtggtgc
3834421 ggcgtgatcg ccgtcggtag cggccagctg cccggctggt ttccgaaggc ggcagcgacc
3834481 aacacttgct caaccaccgg agcgtgagga gtttcattca ccgtgatagc cgtgccttca
3834541 tcagtaaaaa gttggtggtt tcttcgttaa cggcatatta ctcacagctt tctttgcgct
3834601 aatttaggcg tactcacagc atgggatgac ctgggcaaat acctcatcta tccgcccggg
3834661 atagcatgcg gcgcaggcgg cgaatgcggc gcagatgaac gcagagttaa ttctcacgca
3834721 acggtccgat attgcacgcc aacggacgcc tattgacgga aattcggcag cgcccctagc
3834781 gtctatcctt gacggtagtc atcggtgacg ccactccact tcagttgcac aactcgcgcg
3834841 tccgcgaacc caacctccac ttgggcgtgt cgtgcagaga gggaatcagc aatgccacag
3834901 ccggagcagc taccgggacc caacgcagac atctggaact ggcaattgca aggcctgtgt
3834961 cgcggcatgg actcatcgat gttcttccat cccgacggcg agcgtggccg tgcccgaacg
3835021 cagcgcgaac aacgcgccaa ggaaatgtgt cggcgctgcc ccgtgatcga ggcgtgccga
3835081 tcccatgcgt tagaggtcgg tgagccctat ggcgtttggg gtggcctgtc cgaatccgag
3835141 cgcgacctac tcctcaaggg caccatggga cgcacccgcg gcatccgccg cacagcttaa
3835201 gccgcgcgag cagacgctaa agcccccgca cgctcggcgt gtcgggggct tttgcgtctg
3835261 ctgaccggag ttcagtgcgc gtgcccgtgg tgatggtcgt gatcttctgc cttggccggc
3835321 ttgtcgacca cgaccgtctc ggtggtgagt accatccggg caaccgatga cgcgttcaac
3835381 accgccgacc tagtcacctt gaccgggtcg atgacgccgt cagcggccaa gtcaccatag
3835441 ctcagggtgt tcacgttcag cccatgcccg gcgggtagct cgctgacctt gttgaccacc
3835501 accgagccgt ccaagccagc gttggcggcg atccagaaca acggcgcggc aagggcttcg
3835561 gagaacacgt cgacaccgag gacctcgtca ccggtcagcg acgcacgcag ttcggtcagc
3835621 gccttgcggg cctggtggat gagcgaggct cccccaccag ggacgatgcc ctcctcgacc
3835681 gcggccttgg cggccgcgac cgcatcctcg acgctttcct tgcgctcctt gagtgcggtc
3835741 tcggtggcgg cacccacctt gatgacagca accccgccgg ccagtttggc cagccgctcg
3835801 ccaagctttt cccgatccca atccgaatcg ctcttgtcga tctcggcacg caagtgcttc
3835861 gcccggttgg ccaccgcttc tgcggtgccg ccgccgtcga caatgaccgt gtcgtccttg
3835921 ctgaccacca cgcgtcgggc cgagcccagc acctccaagc ccacctcgcg cagcaccatg
3835981 ccggcgtcgg ggttgaccac ctggccaccc gtcaccaccg ccaggtcctc aaggaacgcc
3836041 ttacggcggt caccgaagta cggccccttg accgcgaccg ctttcaacgt cttgcgaatc
3836101 gcgttgacga ccagcgtcgc caacgcttcg ccctccacgt cttcagccac gatcagtagt
3836161 ggcttacccg ttcctgcaac cttttccagc aatggcaaca gatcgggaag cgagctgatc
3836221 ttgtcttggt gcagcaggat caacgcgtcc tcgagcaccg cctgctggtt atcgaagtcg
3836281 gtaacgaagt atgccgacaa gaagcccttg tcgaagccga taccctcggt gaactccaac
3836341 tcggtgccca gcgtcgagga ttcttcgacg ctgaccacgc cgtcgtggcc gaccttgctc
3836401 atcgcttcgc caaccaggtc accgatctgc tcgtcgcgcg aggacaccgt cgccacctgc
3836461 gcgatgccgg tcttgccgga caccggcgtg gccgatgcca gcagcgcctc ggataccgcg
3836521 tcggcggcct tgccgattcc cacgccgagc gcgatcgggt tgacgccggc ggccactagc
3836581 ctcaggccgc ccttgatcag tgcctgcgcc aagatggttg cggtggtggt gccgtcaccg
3836641 gccacatcgt tggtcttggt ggccaccgac ttcaccagct gggcgcccaa gtcttcaaac
3836701 ggatcttcca gctcgatctc acgtgccacc gtgacgccgt cgttggtaac cgtgggtccg
3836761 ccaaacgcct tggccagcac cacatgccgg ccgcgcggcc ccagcgtcac ccgcacggtg
3836821 tcggccagct tgtccatgcc gacctccatg gcgcgacgcg cggtttcgtc gtattcgatc
3836881 agcttgctca tcaggctcct ctacgcaggg ctagtccgct aacgcatgcc gccccggaaa
3836941 tcacccgtgg tgagcacggg gatcgccggg gcggaacacg ctctactact tggaaacgac
3837001 ggccagcacg tcgcgtgccg acaggatcag gtattcctcg ccgttgtact tgatctcggt
3837061 gccgccgtac ttgctgtaga tgacggtgtc accctccgca acgtccagcg ggatccgctt
3837121 ctcgccgtcc tcgtcccacc ggccagggcc gacggcaacg acggtgccct cctgcggctt
3837181 ctccttggcg gtgtcaggaa tgaccagacc ggacgcggtc gtggtctcgg cctcgttggc
3837241 ctgcacgaga atcttgtcct cgagtggctt gatgttcacc ttcgccacga ttggagccct
3837301 ccactatttg gatcagagcc cgggacgctc gcccggaccg gagttggcgg tcggtccggg
3837361 gcgtgccccg gaaccgtccg aattaccagg tgattcggca ttcgtccgcg ccctcgcgcc
3837421 gtcgtcgcgg gtgccgacgc aggggttagc cgattgccat ctagcactct atacatgaga
3837481 gtgctagcac tcaagggcgc ccccttgctt cctggttgcc agcgtgtccg ggtacgccag
3837541 gtgcaatgtc cgggtcaccg cacctgcccc tgcatcacgg gcagacccgg gtcactgggc
3837601 acgtccagcg gcgacggcgg cgctcccgcg gccaccagct gcgcggcgaa cgccgcgatc
3837661 atcgccccgt tgtcggtgca tagccgggga ctggggatcc gcaacgtccg gcccgcctcg
3837721 ccgcagcgct gtgtggccag ctctcgcagc cgggagttcg ccgccactcc ccccgcgatc
3837781 agcagcgttg agacgcctag cgcagtggcg gcccgtaccg ccttcatggt caacacgtcc
3837841 gcgacggcct cctggaatcc ggcggcaatg tcggcggtac ggaagcccgg gtcagccgcg
3837901 tggctttcca cataccgcgc gacggccgtc ttgagcccgg agaagctgaa cgcatagcgg
3837961 tcatcggccg ggccactcat gccgcgcggg aaaacgatgg cgtcccgatc accggtgcgc
3838021 gccaggtcgt cgagcgcctt gccacccgga tagcccaatc ccagcaaccg ggccaccttg
3838081 tcgtaggcct cgccggcggc gtcgtcgacg gtgctgccca gctcgatgat cggctcaccg
3838141 agcgagcgaa cgtgcaacag gtgggtatgt cctccggaca ccaacaacgc cacacactcg
3838201 ggcagcggcc cgtgttcgta gacgtcggcg gccaagtgcc cgcccagatg attcaccgca
3838261 tagaacggca ccccccaagc agccgaatat gccttggccg cagccactcc caccaacagg
3838321 gcgcccgcga gcccgggacc gatggtggcc gcgacaatgt ctggctgttt caagccggcg
3838381 gccgccagcg cgcggcgcat cgcgggaccc agtgcctcca ggtgcgcacg ggaggcaatc
3838441 tcggggacca cgccgccgaa ccgaacatgc tcgtcgacac tggaagccac ctcgtcggcc
3838501 aacaatgtca cggtgccatc gggatcgagc cgcgcgatgc cgacaccggt ttcatcgcag
3838561 gaggtttcga tgcccaagac tgtcgtcatg acgggtcccc cgaatcccta cgcatcgtgt
3838621 acgcgtcggc gccgctgacc cggtaatatc gccggcgcaa gccgacccgc tggaatccca
3838681 cgctgcgata cagcgcaaga gcggcgtcat tatcggtgcg gacctccagg tagaccacac
3838741 cacccctggc aaagtccagc agttcgcgca gcaaccgacg gccgatgccc cgcccctggt
3838801 aggccgggtc cacgccgatg gtgtgcacct cgtactcgaa cggcggtgtt cggcccaacc
3838861 gcgagattcc agcgtaaccg accagcgtgc caccgctgcg cgcacccaca tagtggttgt
3838921 gcgggctggc cagttcgcgg ttgaacgccg ccggcggcca gggatcgtca ccgacgaaca
3838981 gctgggcctc cagctcggcg caccgctggg cgtccgcgcg cgtcagcgcg ccgatggtga
3839041 cgggctcggt gtcggccgtc acgtgcaaac cgccagcggc ttggcatccg gccggcgaag
3839101 atacagcggc actaacggcg ccggcttgtc ggcccagttc accgcggcta ccagacccgc
3839161 cggcgacggg cggctgggct caacgcaggg gagcgcgaac agcgccgcgt gctccggcgc
3839221 accggcgacc gccaatgccg ggccgggatc gacgtcggcc gcggcattaa cggctggtcc
3839281 gaccgtacga atcccgtcgc agtagcgtgc ccagtagacc tcacgccggc gtgcatcggt
3839341 gaccaccagc gtgtcaccga tggtttgccc gccgatggcg tccaggctgc acacgccata
3839401 caccgggatg cccagtgcgt gcccgtacgc ggcggcggag gccatgcctg cgcgcagccc
3839461 ggtgaacggg cccggaccgc agcccaccac gacggcgtcc aggtcggcca ttgtgagcgc
3839521 ggcatcggca agcgcagcca gcacgttggg agtcagccgt tccgcgtgcg ctcgggcgtc
3839581 gacggtgacc ctctcgccca gcacaaccag atcatgacgc cgcacgatac ccgccgtgac
3839641 cgccggtgta gcggtgtcga tggccaagac ggtgcttatt tgcacgcggc tcatgaccgg
3839701 ccccacgacc aagtcgcgat cctggtgtcg gagtggctaa cccgctccag gcggacgtcg
3839761 aggtggcgct gcgagagccg ctcggccagg ccctcgcccc actccaccac gacgacggcg
3839821 tcttcaagat cggtgtcgag gtccagtgag tccagctcac tcagcaggtc ggcgctgttg
3839881 tggtccagca gtcggtagac gtcgacgtgg accatcgccg gcgtgcccgg ccgccgcggc
3839941 cggtgcattc gcgccagcac gaacgtcggc gatgtgatcg gcccctcgac atccatcgcc
3840001 atggcaatac ccttggccag caccgtcttt cccgcaccga gcggaccgga gagcaccacc
3840061 acgtcgccag cgcacagctg ctcacccagc cgggacccca gcgttagggt gtcctcgacg
3840121 cgcggcagcg tcgccgtgcc gccgcccgta agcccagccc tggctttcgg tcgtctgcgg
3840181 ataccctcac ggctcaacgg ttttcagcct cgcgataggt cctggtgata cgtcctcgcg
3840241 ggctggtgac cacttcgtag tggatggtgc cgacaagatc ggcccagtcc tgagccgtgg
3840301 gctcaccccg gatgcccggc ccgaacaaaa tcgcctcgtc gccttcggcc acatcaagcg
3840361 gcccggggcc caggtcgacc atgaactggt ccatgcagat ccgccccaca ccggggcatc
3840421 gtctgccgtt gatcagcacc tccagccgcc cgcccagcga ccggaacacg ccgtctgcgt
3840481 aaccgatcgg cagcagcgcc agattggtgt cgcgtggcgc gatccatgtg tgcccatacg
3840541 acacgccctc ccccgcacga atcgatttca ccagcgcaac agcacatttc acggtcatcg
3840601 ccggcaccag ccccatgtca ccgagggcgg gtaccgggct tagcccatac accgcgatgc
3840661 ccggccgcac caggtcgaac gtcaggtcgg ggcgcgccat agttgctgat gagttcgata
3840721 gatgcgccac ctcgaaccgc accccttgtt cgcgggcctg cgccagaaag gcggtaaacc
3840781 gttgggcctg aacatcgttg atggaatcgt caggcttgtc ggcgtaaacc atatgcgaca
3840841 tcagcccccg cagccggacg gcgtcctcgg ccatggcttg gcgtaacgcg gtcagcatgg
3840901 ccgggaattg tgccggtccc acgccattgc ggttcagccc ggtatccacc ttgacggtca
3840961 ccgtcgccgt ccggccggtc cggcgcaccg cgtgcaacag ttcgtcgagt tggcgcagcg
3841021 aggacaccgc gacctgcacg tcggccagca gcgcgggccc gaagtcgatg ccgggcggat
3841081 gcagccaggc cagcaccggt gcggtaatgc catcagcgcg cagcgctagc gcctcgtcga
3841141 cggtggcgac gccgagttcg gccgcaccgg ctcccagggc ggtttgggcg acgcgcgtag
3841201 caccgtgacc gtagccgtcg gccttgacca ccgccatcag ctgcgcgtgg ccggcgtgct
3841261 cacgcagcac ccgcacgttg tgttcaatag cgcccagatc caccatggcc tcggcgagga
3841321 ggccaggtgt ctgggatatc ggtgtcatgg ccaacgaagt cgtgccccgc ccatctgtcg
3841381 tgtcgtttgg ctttccgaca ttctcccaga accgtttcac tgagcagtat tccggcctgt
3841441 gcccgattgc cccgggtcgc ggtgctgggc tgcagccgtg tcggcgtgac tgtcctgtgg
3841501 ctcggtggtt ggttgccgat cacccggtgt ttggctcaga ttgccggtgc cgcatgatgg
3841561 ttggcgtcaa tagagtgcgg atcggccggc atgaattgac gggagcgtag cttgaccgcg
3841621 gcccatcacc cgtggcagga aacagttgca gtgtgtacta ttcgccctag actgccgcag
3841681 ttccggggga agtgaaccta ttgcgcccgt gcatcactgc acgggtatgg gctttggcgg
3841741 tcgcttcgca ccatcaacgc cgacagtgcg gacagcgcaa accgacggca caccccttgc
3841801 acggatgtgg ggtgtttttg agatggagcg aaagtaggcg tgtcttttat tttcacaacc
3841861 ccccaggcat tggacaacgc ggctaagtcc gtgtcgggga ttcacgattt gtggcgcaaa
3841921 ggacgctaag gcatcgatcc cggtggtcaa cgctatttga gccccccgct tccgacccgg
3841981 tgtcgaatag ggatgaggcc gctcctccgc cagcacatga ggcagtatca ccagatcagc
3842041 tttccggcca tagagcatcg tcaccgggtt aggcatggtt taggcagcgc ttagctgaga
3842101 acgccgaggc gtgtcggctc gccgaggccc aaaacagcac aaccttgcac tgatctagct
3842161 gaagaccaaa ccggcacagc agacattgcc atacgcgaca acagccgtca tcaaccgaaa
3842221 ggagcaaaga acaaacagat gcatccaatg ataccagcgg agtatatctc caacataata
3842281 tatgaaggcc cgggcgctga ctcattgttt ttcgcctccg ggcaattgcg agaattggct
3842341 tactcagttg aaacgacggc tgagtcgctc gaggacgagc tcgacgagct ggatgagaac
3842401 tggaaaggta gttcgtcgga cttgttggcc gacgcggttg agcggtatct ccaatggctg
3842461 tctaaacact ccagtcagct taagcatgcc gcctgggtga tcaacggcct cgcgaacgcc
3842521 tataacgaca cacgtcggaa ggtggtaccc ccggaggaga tcgccgccaa ccgcgaggag
3842581 aggcgcaggc tgatcgcgag caacgtggcc ggggtaaaca ctccagcaat cgcagacctc
3842641 gatgcacaat acgaccagta ccgggcccgc aatgtcgctg taatgaacgc ctatgtaagt
3842701 tggacccgat ctgcgctatc ggatctgccc cggtggcggg aaccgccgca gatctacagg
3842761 ggcgggtagg tccaagaggc cggcgcggtc ttgcaggcca gcaacaatgc cacggtcgac
3842821 caggcccatc gcttccgggc ccgcacgaca caccgcggtt tcagatgaat caggcgtttc
3842881 acaccatggt gaatatgctg ctgatccgtt tacacgtcag gttcgactga tctagcttca
3842941 ggttcgactg atctagctga aaaccaaacc ggcacagcga cattaccata cctgacaaca
3843001 gccgtcacca accgaaagga gcaaagaaca agcagatgca tctaatgata cccgcggagt
3843061 atatctccaa cgtaatatat gaaggtccgc gtgctgactc attgtatgcc gccgaccagc
3843121 gattgcgaca attagctgac tcagttagaa cgactgccga gtcgctcaac accacgctcg
3843181 acgagctgca cgagaactgg aaaggtagtt catcggaatg gatggccgac gcggctttgc
3843241 ggtatctcga ctggctgtct aaacactccc gtcagatttt gcgaaccgcc cgcgtgatcg
3843301 aatccctcgt aatggcctat gaggagacac ttctgagggt ggtacccccg gcgactatcg
3843361 ccaacaaccg cgaggaggtg cgcaggctga tcgcgagcaa cgtggccggg ggtaaacact
3843421 ccagcaatcg cagacctcga ggcacaatac gagcagtacc gggccgaaaa tatccaagca
3843481 atggaccgct atctaagttg gacccgattt gcgctatcga agctgccccg atggcgggag
3843541 ccgccgcaga tccacaggag cgggtaggtc caagaggccg gcgcggtctt gcaggccagc
3843601 aacaatgccg cggtcgacca ggcccatcgc ttcgctgctc gcacgacaca ccgcggtttc
3843661 agatgaatca ggcgtttcac accatggtga acatgttgct gacgtgtttt gcatgtcagg
3843721 agaaaccgag atgacgatca acaaccaggt gagcgacgct gacacccacg gcgccaccac
3843781 cggcgcccct gtcgaccgcc acgtaattcc ccaggggttg gcgtcacgta attccccagg
3843841 tgtgtgcctc agtggtaggt cttagcggcc cgtgtgggcg ttgtctagct ggtggtgcgg
3843901 ccgggtctct tgcggggtcg gtagctgggt ccgtccatga ggatttggtg gctggtgttg
3843961 atgagccgat ccaggagtga ttcggcgacg acggggttgg ggaacaggcc gtaccagtta
3844021 ttcggtgcgc ggttgctggt caagatcagc ggtttgccag tgatggcgcg gtcgctgatg
3844081 agctcgtaga ggtcatcagc gtgcatggcg gtgtgctcac gcatcgcgaa gtcgtccaga
3844141 atgagcacga gcggcttggt gtattcgcgg atgcgttggc cccaggatcg gtcggcgtgc
3844201 ccgccggcga ggtcggagag catgcgggag gttttggcga agcgcacgtc gccgccgcgg
3844261 cgggccacgg cgtggacaag tgcttgtgct acatgggttt ttccgacgcc gaccgggccg
3844321 tggaggatga ccgattcgcc ggcatccagc cagcgcagcg cggccagatc gcgcaacatc
3844381 gcaccgggca gtttcgggtt ggcagtgaag tcgaagtctt cgaaggtggc ttgggcttcg
3844441 aacttggcgc ggcgtaatcg tcgtgtcagg gcggcggact cgcggcgggc gatctcgtct
3844501 tcacgcaacg cttgcaggaa ttccagatgc cccaggtcgc cgttgcgggt ttgggccagg
3844561 cgggcgtcga gggtgtcgag catgccggac agtttcaggg tacgtagcgc attacgcagc
3844621 gccggatcac agatagacat ggatgcttct ccttgagaat agcgatgtgg attgtgtcgg
3844681 gatggttcgg gattccgctg tgagatcagg cgacggggtg tgtcggtgcc gaactgttca
3844741 gggccgcgca ggaacgcccc cagcggtgct tgccggacta ctggtggtcg gctcgttggc
3844801 ggcgtgttcg gtgccggcaa caaggatgcc cttgatggtg cgatagctcg ggtcgccgac
3844861 ctcgatggcg cgggcgcagg cggcctccag ccggtcgcag ccgtgtttgt cgcgtagccc
3844921 gagcacgcct tgggccgacc gtaggtggtg gatggcgttg tcgcgcatga attcggcgat
3844981 cacttgctgg ctggctgggc cgaccagttc ggcggtgtgt cgacaccagg tcggggtgcg
3845041 catgtggaag gcgatcttct ccggtgggta gtgggagaag tcggtggagc gcccgctggg
3845101 tcggcgcaca tgggtggcca ccacatcgtt gccggcgaag atctgcacca catcaccggc
3845161 ggtgcgcgcg tgcaggcgtt gcccgatcag ccgccacggc acggaataga gtgccttgcc
3845221 aactttgagg tgcgtgtcca ccccgacggt gccgatcgac cagctggtga gttcaaatgc
3845281 cctgggcggc aatgcgatca acgcttgttg ctccacagct tcgaacatcc gcaggggttg
3845341 ggcgccctcc aaggcacgta agtaccgaag cccggccact tcggtgctcc aggtgaccgc
3845401 cgcctgctgc atctgggcca gcgaatcgaa ctcgcggcct ttccaaaacg agtcccgcac
3845461 ataggtcatc ggccgctcca cgcggggttt atctttgggt tttctggcgc gggccgggtc
3845521 gaccagcgtg gcgtagtggc tggccagctc ggcgtaggag cggttgatct gcgggtcgta
3845581 caggtcgggc ttgtccaccc cggtcctgag gttgtcacac actagccgcg ccggcacccc
3845641 gtcgaagaat tcgaatgcgg cgacatggca agcacaccaa gcggtttggt ccatccggat
3845701 gaccggacgc acgaacaggt gtcgggagaa cgccagcacc atcacgaacg cccacaccgc
3845761 gacccggcgc gcggtggccg ggtcgaacca catgcccagc cgcccgtaat cgatctgcgc
3845821 ctcactaccc gcatcgaccg gtccgcgcgg caccgtgact ctctcgcggg ccacctcctc
3845881 ggcgaaatgc gttgcgatcc aacgcctcac cgacgactcc gacgccgcca ccccgtggtc
3845941 gtcacgcagc cgttgggcta tcgtggccac cgtgacatcg gcatccagcc agtccttgat
3846001 ccgatcatga tgcggcgcga tcagcggcca cgtcgacgcc cgcgccgccg gatcattcag
3846061 gaaaccaccc gccgatcaac tccgcccact gctcggcgct cagcggctcc ccaccgggct
3846121 cgataccggc ggcgatcgcc ggcgccgtat atttgcggac cgtcttgcga tcgatgccca
3846181 gcgactccga taaccggacc tgagagcggc ccgcgtgcca gtgggtcaac aactcgacca
3846241 aatcgagcat caagatactt ctcctcgcca tcagcgccct tccatccgtc agccgacgga
3846301 tgcagagcga accttgcagc aaggcccaca ccgggcagac acaccgccca tggtggggaa
3846361 ttacgtgaca gccggggtgg ggaattacgt gacggacaac ccctcaaacc tggggaaata
3846421 cgtgaccgct gacacacagg tattgacaat tgctcattca ggctcaaatt gcctgtgccg
3846481 catgatggtt ggcgttaaag cgtgaggacc tgccggatga attgacggga gcgtagctgt
3846541 gaccgcggtc ccgtcacccg tggcaggaaa cagttgcagt gtgtactatc cgccctagac
3846601 tgccgcagtt ccgggggaag tgaacctatt gcgcccgtgc atcactgcac gggtatgggc
3846661 tttggcagtc gcttcgcacc atcaacaccg acagtgcgac agcacaaacc gacggcacac
3846721 cccttgcacg gatgcggggt gtctttgaga gggagcgaag tagccgtgtc ttttatcttc
3846781 acaacccccc aggcactgga caacgcggct aagtccgtgt cggggattca cgatttgtgg
3846841 cgcaaaggac gctaaggcat cgatcccggt ggtcaacgct atttgagccc cccgcttccg
3846901 acccggtgtc gaatagggat gaggccgctc ctccgccagc acatgaggca gtatcaccag
3846961 atcagctttc cggccataga gcatcgtcac cgggttaggc atggtttagg cagcgcttag
3847021 ctgagaacgc cgaggcgtgt cggctcgccg aggcccaaaa cagcacaacc ttgcactgat
3847081 ctagctgaag accaaaccgg cacagcagac attgccatac gcgacaacag ccgtcatcaa
3847141 ccgaaaggag caaagaacaa acagatgcat ccaatgatac cagcggagta tatctccaac
3847201 ataatatatg aaggtccggg tgctgactca ttgtctgccg ccgccgagca attgcgacta
3847261 atgtataact cagctaacat gacggctaag tcgctcaccg acaggctcgg cgagctgcag
3847321 gagaactgga aaggtagttc gtcggacttg atggccgacg cggctgggcg gtatctcgac
3847381 tggctgacta aacactctcg tcaaattctg gaaaccgcct acgtgatcga cttcctcgca
3847441 tacgtctatg aggagacacg tcacaaggtg gtacccccgg cgactatcgc caacaaccgc
3847501 gaggaggtgc acaggctgat cgcgagcaac gtggccgggg taaacactcc agcaatcgca
3847561 ggactcgatg cacaatatca gcagtaccgg gcccaaaata tcgctgtcat gaacgactat
3847621 caaagtaccg cccggtttat cctagcgtat ctgccccgat ggcaggagcc gccgcagatc
3847681 tacgggggcg ggggcgggta ggtccagaag gccggggcgg aacctgtcaa catttctgag
3847741 acacgatttt cggggattta ttgagtcggc tggtcctcct tcggtggtgg gttgatcgcg
3847801 ctgaaggccg gtagcgcggg tggctcgggt ggtttgcgaa cgaatccgct cgaggtggtc
3847861 tcggtaggcg gtgtccagaa cggtggcgcg gtgccggcgg atctgatcgg cgcggccgta
3847921 gtgcacgtcg gcgggcgtgt gcagtccgat gccggaatgc ttgtgttcgt ggttgtacca
3847981 gccgaagaac cggtcgcagt gcacccgggc cgcctcgatc gactcgaacc gtttcgggaa
3848041 gtcgggccgg tacttgaggg tcttgaactg ggcctcagac aacgggttgt cgttgctggt
3848101 gtgcgggcgt gagtgcgact tggtgacacc gaggtcggcc agcagcagtg ccaccggttt
3848161 ggagctcatc gacgagccgc ggtcggcgtg cagggtcagc tggtcggcgc tgatgtgctg
3848221 ggcggcaagg gtttgcgcga tcagccgctc ggccaagacc ttcgactcac gcgaggccac
3848281 catccacccg accacgtagc gggagaagat gtcgaggatc acatacaggt agtaatagct
3848341 ccactttgct gggccacgca gcttggtgat atcccacgac cacaccgaat tcggctgatg
3848401 agcaaccaac tctggcttca ccgcagccgg gtgggtggcc tggcggcggc gatcaccggt
3848461 ctggccgcgc tcacgcagca gccgatacat cgtggactcg ctgcacaggt agatgccctc
3848521 gtcgagcagc gtggcatata ccaccgccgg cgccatgtca gcgaagcgct gcgagttcag
3848581 caccgccagt acgtgctcac gttcggccgc actcagcgcc cgcggctgcg cgctctcccg
3848641 cggtcccgac gggtcggtca ccgccgtgct ggtgaacgta tccgattgtg ccgacaaccg
3848701 tttcgagtgg gcccggtagt aggaggccgg cgcacgaccg gtcgccgcac acgcggcccg
3848761 aaccccgatc aacgggatca tctcctcgat ggccgtgtcg atcacgctca gcgctcactc
3848821 tcgcacatcg ccgcgctgtc ggctcagagc ctctccaaga gcgcggacag ttccccctgc
3848881 acacggatca cctcgcgtgc ggtgtcgagc tcggcgcgca gccacgcgat ctcggcgtca
3848941 gcggcattgg cgccggcctt gcccggcttg gggccccgcc gcgccgacag cgccgccaac
3849001 gccccccgat cacgctgatg gcgctattcg gtcagcaacg acgaatacag gttctcccgc
3849061 cgcaagatcg cacccctttc cgtgcgatcg gcgcggtcat actcatcaag gatcgccagc
3849121 ttgtacttca cggtgaacgt acgccgctgc gcccgctcag gcacctgagg atcaggcacc
3849181 tcgtccacgg tgaccgacga accccgtcgg ccagtaccag ccctattagt caacctcgtt
3849241 ctcttcgtac tcgccctcag gctcagtaaa catctccact cgcagtgtct cactcaaggt
3849301 tgacagagag ggtcggcgac gcggtcccac tgagcgccga cctcctcagg gtcggtgtgg
3849361 gcgaaaatcg tcttgaccgc cacggtcacc gccggggcgt gtttggccgc taccgcggtg
3849421 tacaggtttc gcatgaaatg cacccggcaa cgctgccacg acgccccact gaactgttgt
3849481 gccacagcgg ctttcagccc agcatgggca tcggagatca ccagatgcac cccggtcagc
3849541 ccacgcgctt tcagtgaggc caaaaactca cgccagaact cgtaagactc gctgtcaccc
3849601 acagcggtgc ccaacacttc gcgggtgccg tcgatggaca ccccggtggc caccaccaga
3849661 gcctgagaca ccacgtgcgc cccgacacgc accttgcaga aggtcgcatc gcagaacaca
3849721 tacgggaact cggtgtgggt caagctgcgg gtccgaaacg cctcgatctc ggtgtccaga
3849781 ccggcgcaga tgcgtgagac ctcggattta gacaccccgg cctgcacgcc catcgcggcc
3849841 accagatcat cgacactgcg cgtcgacacc ccgtgcacgt aggcctccat gatcaccgcg
3849901 tgcaacgctt tatcgatgcg gcggcgccgc tccaaaagcg acgggaagaa cgaaccggcc
3849961 cgcagcttgg ggatctgcac ctcgatatcg ccggccgtgg tcgacactgt cttgggccgg
3850021 tgcccattgc ggtgcacgat gcgcccatcg gagcgctcgt agcggcctgc accgatcgcc
3850081 tcggtggctt cggcctcgat caacgcctgc aacccggcac ggatcagctc ggcaaacacc
3850141 gccgaggcat cagcagcttc actcgcgtta cggaccgctc agttgcttcc cccaacgggg
3850201 ctttcgacgc tgggcttcga ccctgcccgt ttccaaacca agcggccagc ctgctaccgg
3850261 gcctcctgac agctacccgg accggactcc caccggcagg cgacgacgag ctttgatcag
3850321 gtcatgacct aagacatcac ctcctgatca ctgggcgcac cggctgcagt actagtgcgc
3850381 gaaatgctgt gcgtcgaagt ggccacccgg cttgaccttg tccagggcag ccaacgcggt
3850441 gaccgcgtcg tcgtgcaggg cccgcgccag gtcggcggag agtccttccc gaaccacgat
3850501 ccgcagcacc gccacgtcgg tggcgttgtc cggcatggtg taggcgggca cctgccaccc
3850561 gaaggtccgc agctcatggg agacgtcgaa ctccgtgtac ccgcggtcgc cggcgagccg
3850621 gaagctgacc accgggatcg ccgaaccatc cgagatcacc tcgcaatgat ccacctcgcg
3850681 cagctggtca cccagccacc gggcggtgtg cgacagcgcc tgcatcacct tggtatagcc
3850741 gtcgcgcccc agccgcagga agttgtagta ctggcccacc acctggttac cgggacggga
3850801 gaagttcagg gtgaaggtcg gcatgtcgcc gccgaggtag ttgacccgga aaaccagatc
3850861 ctccggcagg tgctcgggcc cgcgccacac gacaaacccg acgccgggat aggtcagccc
3850921 atacttgtgg ccgctgacgt tgatcgacac cacgcggggc agccgaaaat cccataccag
3850981 gtccggatgc aaaaacggca ccacaaagcc cccactggcc gcgtcgacgt gtaccgggac
3851041 gtccacaccc ccgccagccg ccagtttgtc cagcgcggcg cagatctcgg cgatgggttc
3851101 gagttcaccg gtataggtgg tgcccaagat cgccaccacg ccgatggtgt tctcgtcgac
3851161 ggcggcgagc acctgctcgg gggtgatgac gtagcggccc cgctccatcg gcaggtaacg
3851221 gggttcgacg tcgaagtagc ggcagaactt ctcccacacc acctggacgt tcgaacccat
3851281 caccagattg ggcatgcgcc ccttccaaga ccccacccgt tgccgccaac gccatttcag
3851341 ggccagccca cccagcatca ccgcctcgct ggagccgatg gtggacaccc cggtggcgct
3851401 ggtggggtcg tggtcgcgca gaccctcggc gtgaaacagg tcggcgacca tggacacaca
3851461 gcgcgcctcg atggccgcgg tcgccgggta ttcgtcctta tcgatcatgt tcttgtcgaa
3851521 cgtctcggcc atcagctttt cggcctccgg gtccatccag gtggtcacga aggtggccag
3851581 attcagccgc gagctaccgt cgagcatcag ctcgtcgtgg atgaagcgat aggccgcctc
3851641 gggatccatc gactcatcgg gcatccgcag cgccggcacc ggtgcggtga acatccgacc
3851701 ggtgtaggcc ggagcgatcg aatgcgcggg cacggacggg tgactgcgag acacggcgga
3851761 tcctttccgg gcttgttgcg gactggcagg actacagggc agccagagcg gcccgaatgt
3851821 ggccgctgat gcgcgacgcc gacgtgggcg catcgccggg gccgggatcg gcggccgcgg
3851881 ccgccgatgc ccgggcgtgc acgaacgccg cggccgcggc cgcctcccca gacggcaatc
3851941 ccgacgccag cagcgcaccg atcatcccgg acagcacgtc accggacccg gcggtggccg
3852001 cccaggactg gccggccgga ttgagataga ccgggccgcc gggatcggcg atgacggtga
3852061 cattgccctt gagcagcacg gtggcgccca gcgcgtcggc cagctggcgg caggccccca
3852121 cgcggtcgtc accgggcggc gccccggcca gccgggcgaa ctcaccggcg tgcggcgtca
3852181 agaccgtcgg ggcgttgcgg cccgccacca gatcggggtg gtccgccagc atggtcagcc
3852241 cgtcggcgtc gaccaacacc ggcaggtcgg tgtccagcgc gaaccacaac gcggcggccc
3852301 cggcttcgtc ggtgcccagg cccggcccga cgacccaggc ctgcacccgc ccggccgccg
3852361 ccggggtggg cgaggcgatg acctccggcc agtgcgcgag gacttccgca tgggcggtcc
3852421 cggcgtagcg gaccatgccg gaggtggcgg cgacggccgc cccggtgcac agcacggccg
3852481 cacccggata cgtcgacgac ccggccagca cgccggtcac gccctgggtg tatttgtcgt
3852541 cgcggggacc gggcaccggc cagcgcgcgg ccacgtcggt agcctcgaaa cccaacacgt
3852601 cggtgtgcgc caggtccagc ccgatatcga caaggacgac gcggccgcag tcggccagcg
3852661 cgtgcaccgg tttgagcccg ccaaaggtga cggtcagcgc ggcgtgcacg gcggggccgg
3852721 tgatcgcccc ggtcgccaca tcgatgccgc tggggatgtc gacggcgacc accggtatgg
3852781 cggcggcctg aaccgcggcg aacacctgcg cggccgccgg tcgcagcggc cccgagccgg
3852841 agatgccgac caccccgtcg atgacgagat cggtcgccgc cgagacactc tcgacgaggc
3852901 gacccccgga tttggtgaac gccgccagcg ccttgcgatg cgtgcggtcc gggttgagca
3852961 gcaccgcgtc ggcggcggcg ccgcggcgtc gcaggaacgt cgccgcccac agcgcgtcgc
3853021 caccgttgtc gccggatccg acgaccgcgc acacccggcg gccgaccacc ccacccgtgc
3853081 gagcggtcaa ctcacggccg atctcggtgg ccagcccgaa ggccgcgcgt cgcatcagcg
3853141 caccgtcggg caggctggcc aacaggggcg cctcagccgc gcggatggtg tcgacagagt
3853201 agtagtggcg catctcaggc ccgccgtcct cgggtgccgc gcctgtgcag cagacttttg
3853261 attctggccg gattccacag ccgaccgtcg cgttcccggg ccatcggata gaacagcaga
3853321 ccaatcagga tggacgcgaa gtgaccgacc gcggtgaagt ccagctcggc tttgtccatc
3853381 gcgatcagcg gaaaaccaaa gatgaccagc agcaccccga gatagcccca gcgccacggt
3853441 ttggcgatgt gataggtcaa taccgccatc acaccgacca ggaagtagct gaccccgata
3853501 tcacgagcgt gcaccatcct ttcggaggcg tctcggtgct ggatcgccag atagagcagg
3853561 ccttcgctca aataggtggc accgatgtga gcggtcaatc ccacggtgag ccaacgcaag
3853621 tggccgagcc aatgctcggc gggcgctagg aacagggtga acagcagcag gtacggttcc
3853681 aaattccggc cgtcgatcca caacaggctg gaaaacagca cctcgagcgg atcgcgcccc
3853741 aactcggcga tgttggtgga ccggtgcagg agcacgaaat gcagctggct cccggtgaga
3853801 ttgttctgga tgatcgtggt gatcaccaac acgaccagcc aggcataggt caacggggcg
3853861 ttgctgacga agtgccacac cgcgagcgcc cacgatcgca gccgtgccac caccgatgcg
3853921 tccgccacgg gtcaacactt acatggtttc gtcgacgtca ggcttcaggt gccaccacca
3853981 gcagaggata tacagcacca tcgaggtcac caatgcgacg accacccaga gtacgaccgt
3854041 gacgtcgatc caaaatccga ttgggggcgc gtcgggaagc gcattgcgca gcggtatcac
3854101 cgcaaaaagc attgccgcat accacgttgt catcggcggc tggaattgcc gccggccacg
3854161 tgcggtttga accgcaacga acaggcccac cccggccagc gcgatcaaca caccgacgat
3854221 gacggtgccg aatgccacgc tgctcggcga tcggtgcaac cccactcggt acggggcagg
3854281 cacattggcg tcgccgacac cggaaatgtc gacgttccag cccggaagcc ggtcgacgaa
3854341 tgtcaccgac acacgttccg gcgcgtgcgc ggctccgcgg tagagctgga ccgtgatcgg
3854401 ccccgaacgg tagtggtcga acggccaatt cgcgggatcc ccggagatgg tcagcgggac
3854461 gggaaagacg ccgggcagcg aaccactcga ccaggtgcgc ttggtaggcg ttaccacgga
3854521 tgtgaccgtg acggtgaggt cgtccttgag gccctgggtt tgcgaatcca gcagctcagt
3854581 cccaggtgac acggcgaggt tggcaaccag cacgcccttg atcgtctgaa gctgctcgac
3854641 gtgcagggtc accgtggtcc cgtcggccgt cggccgaccg tgggcgactt catgaggtcg
3854701 gccgaggccg gtgctgtgat acaacgcgat cacggtgacg taggccgcaa tcacgagcac
3854761 caaaccgaca acgactctca ggatgcgtcc caactcgcta cccgcccact tgtgcgttcc
3854821 ggcccggaaa ttgtaaccgc gggacccctc cgtcagcgga tgccaccgcc aggccacgtg
3854881 attgtgcgac agccgccatc ttcctgtggt aggtgatcat cgccgtcaac tccgcaccca
3854941 acgtctccgc ggtcgccacg tggatcgcgt cgagtgtctt gggccgccag gtcccgtacc
3855001 gtgagccacc tcgactattc gacggtgacg gacttggcca gattccgcgg cttgtcgaca
3855061 tcgtagccgc gggcgcgcgc caccgaagcc gcgaacacct gaagcggaat ggttgatagc
3855121 agcggctgca atagcgttga caccgctggg atttcgatca ggtgatcggc gtaggggcgc
3855181 accgtttcgt cgccctcctc ggcgatcacg atggtcaccg caccgcgggt ctggatttca
3855241 cggatgttgg acagcagctt ggcgtgcagc gtggccgacc ccttgggtga gggcatgacg
3855301 acgatgaccg gtaggccgtc ttcgatcagc gcgatcgggc cgtgcttgag ctcgccggcc
3855361 gcgaaaccct cggcgtgcat gtaggccaac tccttgagtt tgagtgcacc ctccagcgcc
3855421 accggatagc cgacatggcg acccaggaac agcacggtcg acgactgggc gaaccggtgg
3855481 gccagctcgg ccaccggtcc ggtcgccgcg atcacccggg ccaccaggtc cggcatcgct
3855541 tccagttcgt ggtactcgcg ctcgacctcg tcggggtatt tggtgccgcg ggcctgcgcc
3855601 aaggcaaggc cgagcagata gttggcagca atctgcgcca gaaacgtttt tgtggacgcc
3855661 acaccgatct ccgggccggc gcgggtgtag agcaccgcgt cgcactcgcg cgggatctgc
3855721 gagccgttgg tgttgcagat cgccagcacc ttggctttct gctccttggc gtgtcggacc
3855781 gcttccagcg tgtcggcggt ttccccggac tgcgagatcg ccaccaccaa ggtgctacgg
3855841 tccaacaccg gatcccgata ccgaaactcg ctggcgagtt ccacttccac gggcagccgc
3855901 gtccagtgct cgatcgcgta cttggccagc agcccggagt gatatgcggt accgcaggcc
3855961 accacgaaca ccttgtcgat ctcgcgcagt tcctggtcgc tcaaccgctg ctcgtcgagc
3856021 acgatccggc cacccacgaa gtgtccgagc aaggtgtcgg ccaccgcggc gggctgctcg
3856081 gcgatctcct tgagcatgaa gtactcgtag ccgccctttt cggcggcagc cagatcccag
3856141 tcgatgtgga aggggcggaa atcgcgccca gcttgtaggc catcgttgcc gtcgaaatcg
3856201 ctgatccggt agccgtcggc ggtgatcacc accgcctggt cctggccgag ctcgaccgct
3856261 tcccgggtgt gctcgataaa cgcggccacg tcggaaccga cgaacatctc gttgtcgccg
3856321 atgcccagca ccaggggcgt ggaacggcgg gccgccacga gggtgccggg gtcgtcggca
3856381 ttggcgaaca cgagcgtgaa atgcccctca agccggcgca gcacggcaag tacggagccg
3856441 acgaagtcat cggccgtctc gccgtgccga tacgcccgcg ccaccaggtg cgccgcgacc
3856501 tcggtatcgg tgtcgctggc aaactcgaca ccggcagtct ccagctcccg gcgcaagacg
3856561 gcgaagttct cgatgatgcc gttgtggacg acggcgatct tgccggcagc gtcgcggtgc
3856621 gggtgcgcgt tgcggtcggt gggacgaccg tgggtggccc agcgggtgtg gcccaggccg
3856681 gtagtaccgg acagcgccgt ggacggcatt tccgccacgg cttcctcgag gttggccagc
3856741 cggcccgcac gccggcgcac ggtgagtgtg ccaccgtcga ccagcgcgat gcccgacgag
3856801 tcgtagccgc ggtactccat ccggcgcagc gcgtccatga cgacgacgta ggcggggcgc
3856861 cgcccgacgt aaccgacaat tccgcacaca gcagaccagg gtagtgcagc atggtcggta
3856921 gggcagtccc gtcgcccaac cgacgctatc gtcgagtttg gccaccgcgc acgaaaggcc
3856981 aacacttgtc caacccatat gcccagcacc agctgaagct catcaggcac acgggtgcgc
3857041 tgatcctgtg gcagcaacgc acctacgtgg tctccgggac gcgcgagcaa tgcgaagcgg
3857101 cgtacaagtc ggcgcagacc tacaacctgc tcgttggttg gtggagtttg gtgtcgctcc
3857161 tcgcgatgaa ctggatcgcg ctgatttcca acttcaatgc gattcggcgg gtgcgagccg
3857221 ccgccgacgg ggcgtccgtt ccccacggcc cgcacgccat cgcccatcca gccgttcccc
3857281 ggggacccat accggcgggc tggtatccag acccgtccgg ggcgggactg cgttactggg
3857341 acggtgcgac gtggacccac tggacccatc cgccacgtca ccgctaacgt cgacgggtgc
3857401 cccggatccg caagctcgtc gccgccctgc accgccgggg accacaccgt gttttgcgcg
3857461 gtgacctggc ttttgccggc ctacccgggg tggtgtacac ccccgaggcg gggctgcacc
3857521 ttcccggtgt cgccttcggc cacgactggc tcaccggcac ctctcgctat tcgggtctat
3857581 tggagcattt ggcgtcatgg ggcatcgtgg ccgccgcccc cgacagcgag cgcggactgg
3857641 ccccatcggt cctgaatctg gccttcgatc tgggcgttgc cctcgacatc gtggccggtg
3857701 tccgccttgg gcctggaaaa atcagcgtgc accccgccaa gctcgggctg gtgggccatg
3857761 gtttcggtgg ctcggccgcc gtgttcgccg ccgccggctt gaccggcacg cacgtcaagt
3857821 ccgtggcggc gatattcccg acggtgacca atccggccgc ggagcagcca gccgcgaccc
3857881 tagacgttcc gggactgatt ctgaccgcac ctggcgatcc gaagacgctg acctccaacg
3857941 ccctcgggct atcccgggct tgggataagg ccaccctacg catcgtcagc aaagcccgag
3858001 ccggtggtct ggttgagggc agacgactga cgaaggtgtt ggggctccca ggcccacacc
3858061 gccggacgca gcgttcggtc cgggcgctgc tgaccgggta cctgttgtac acgctcggcg
3858121 gcgacaagac ttatcgcagg ttcgccgatc cagacctgca gctgcccaag acggacccga
3858181 tcgaccctga agcgccgccg atcaccccgg gggagaagat cgtgacgctg ttgaagtagc
3858241 gcgggacacc ccgacccgtc acggccccgc ctgcggaagc tcgtcggcgg cgatctcaca
3858301 gggggtggct ccctcggaca gcgcttccgg cgaaggccca ttcgccggtt ccggcgcacc
3858361 cggcggcgcc ggcgcagcga ccggaggcgg tggttcggcg accggaggcg cggcaggcgg
3858421 cggcggttcg gcgaccggcg gcagcgtggc ctcctcggcg acatcctggg cacgttcagc
3858481 gggcaccgat tcgtcggcgt cgtcgacctc gtctgcttcg tcgggctctg ttgcttcctt
3858541 cggctccgct gcctcgtcgg cctcttccgg gtgggcatcg tcgccgtcat cagcgttgtc
3858601 ggccgcgtct tcagcgaacg gatcgacggc acccggcgga ttgtcagctg ccaacggatc
3858661 ccccagctgt tcggccaccg aacccagcag gctatccacc gcatcgacga tccggttggc
3858721 aagcccggca agcccggcaa acccgcccag accgccggtg ccgccggcat cgccgaaacc
3858781 accggcgctg ccaacacccg ccggcgtcgc ggaaccatca cctggcgccg atccaaaatc
3858841 cgacggcgtc actggccgcg aggtcacggc cggcaccgga tccggcgggg gaagagcggc
3858901 cgcgggcgta atcgctgccg tcgcgctcgg ttgagccggc accgatgccg gagaaggttg
3858961 gcgaccgggc ccgagatcgt ccggaatctc gaagtgcgcg cgcggcgcgc tggccagctg
3859021 atcggtgacc gcatcatacg acgccgccac accggccgtt gtcgatcgca tcgtggtcag
3859081 ccagtcgttg cgaacatcgt cgtccacgta gggctgtatc tgttggcgaa ccacttcgac
3859141 ggccgtcggc cgatctgccc cctccgtcgt gagcgcttcg gccgcagcca accatgccgg
3859201 ccgctgcgcc agggcacgct cgtcgatcgc aatggccgtc gcgactttgg agtccaccag
3859261 ctgccagagg ttgtcgcgca gcgattcgca gcgttgggcc gcggcacgga cttcggtgac
3859321 caccgaattt ccagtctcac agtgacgctg cacaaagtgc accgccgcgt cggcccccga
3859381 tcccgtccat gccgctgcca agacggcgac ctggctacgc tccatccgca gcgcctccat
3859441 gagcacactg gcggcagccc gcagctgcgc gcagtcagcg tcgagcgcgt gcaggtcaag
3859501 tccgtcttcg ctgccgtacc agtcgtggat ctgggcaggg taggcggtca ggtcgggatg
3859561 ttggtagccc accaggtggc aagcccgcac gtagctttgc gtgtgctcgg ctgcgggcct
3859621 gccctcggcg agacgctcag cgacgttcaa ccggtcagcc accctcaccc gatccgcgcc
3859681 gccgcgcaca ggtcggcctc ggcgtagcgg ttggcgcccg cccgcaacgc aaacgcgatc
3859741 tgcacagccg cccgggacca cactgacaac tcgccggcca accggtctag cctgcagcgc
3859801 aacgcatcgc cacgcgaggc gtgcccccgg cccgcgcagg ctccgccaaa agccagcctc
3859861 gtcaggtgat tgccgatggc gtcatcgatg agctcggcgg cggcgctgaa ccggtcggca
3859921 accgcgtata ccgctgctat gtctatgccg gcgctgttta cgctatcggg tctcatgcct
3859981 attcggacgc cccgcgccgc gtcggggttc cagcatttcc ggttcagcgc gcggtgctca
3860041 ccgcgtcggc gaccgtggcc gccagccgct gggcgacgcc ctcgtcggct gcctccacca
3860101 tcacccgaat catcggctca gttccggacg ggcgcaagag gattcgaccc gtgtcaccca
3860161 gctcggccgc ggcctgctcg accgccgttc ggaccgaggg cgccgcggcg gcggtggcct
3860221 tgtcgacaac ctcgacgttg atcagcacct gcggcaacgt ccgcatcgcc gacgccaggt
3860281 cggacaacga cgagccggtc tgcaccatgc gggtcatcaa ccgcagcccg gtgacgatgc
3860341 cgtcaccggt ggagcccagc gccggcatga cgatgtggcc ggattgttcg cctccgaggc
3860401 tgtagtcacc ggcccgcagc tcttcgagga cgtagcggtc accgacggcg gttgtacgca
3860461 cggtgacgcc ggccgagcgc atggctaggt gcagcccgag gttactcatc acggtggcca
3860521 ccaatgtgtt gcaggccaac tcaccggcct ctttcattgc cagcgccagc accaccatga
3860581 tggcgtcacc gtcgacgagg tcaccgttgg cgtcgacggc caggcaccga tcggcgtctc
3860641 catcatgggc caggcccagg tcggcccgat gggcgagcac cgctgcccgc agcgggtcaa
3860701 ggtgagtcga tccacagccg tcgttgatgt tgcgtccgtt gggttcggcg ttgatcgcga
3860761 taacccgggc accggccgct cggtaggcgc gcggagccgc cgacgacgcg gccccatgag
3860821 cgcagtcgac caccacggcc aggtcatcga gccgggcggt ggcggccttg gccacgtggc
3860881 gcaggtagcg ttcggtcgca tcctcggcgt cgataacgcg gccaatcccc gcgccggccg
3860941 gccgcaaccc gggtccgcgg gagacgccga ggaccagatc ctcgatctga tcctcggtgt
3861001 cgtcatctaa tttgtggccg ccgggcccga agattttgat gccgttatcg ggcatcgggt
3861061 tatgcgacgc cgagatcatc accccgaagt cggcgtcgta ggcgccggtc agataggcca
3861121 ccgcgggggt cggcaacacc ccgacccgca gcgcgtcgac gccctcactg gtcaggccgg
3861181 cgatcacggc ggcctccagc atctcgccgc tggcccgcgg atcgcggcca agcaccgcga
3861241 ctcgccgacc cggtgcgccc gacctcgaca atcgtcgcgc cgccgcggcg cccagtgcca
3861301 gggccagttc cgcggtcaac tcgcgattgg cgacaccgcg cacaccatcg gtgccaaaca
3861361 gtcgacccat acggacaacc tttcacagtt gacggctgcg cacatatcca ctcttggcag
3861421 cgaatatgcc tgttggttca ccgacacgcc gacgagcgca cacaaacatg cacgcttgtc
3861481 gcccgaaagt gatgtcagcg cttgctgtac tggggcgcct tgcgggcctt cttcaggccg
3861541 tacttcttgc gctcggtggc gcgtggatca cgggtcaaga agccggcctt cttcagcgcg
3861601 ggccggtcct ccggcgatac cagaatcaat gcccgggcga tacccaggcg cagcgcgccg
3861661 gcctgacccg acgggccgcc gccgcccagg tgggcaaaga tgtcgaaact ttccacccga
3861721 tccacggtga ccaggggtgc cttgatcaac tgctggtgca ccttgtttgg gaagtagtcc
3861781 tccaagctgc ggccgttgag gtcgaacttg ccggtgccgg gcaccagccg cactcgtacc
3861841 acggcctcct tacggcgccc aacggtctgg atgggccgct ccaacacgaa cgattgtgcg
3861901 ggcccggccg gggccgccgg ggtttgcggg gctggggtgg tttcggtcat tgcgccacct
3861961 gcttgagctc gtacggaacc ggctgctgag cgctgtgcgg atgctccggg ccggcgtaga
3862021 cgcgaagctt gcgctggatc tggcggctga gcctgttctt gggcaacatg ccgaggatcg
3862081 ccttttccac cacgcggtcg gggtggcgtt gcattagctc accgatggtg cgcttgtgca
3862141 ggccgccggg ataccccgag tgccggtaaa ccatcttgtg ctgcagtttg tcgccgctga
3862201 tggcgacctt gtcggcgttg atcacgatga cgaagtcacc gccatcgaca ttgggggcga
3862261 acgtcggctt gtgcttgccg cgcagcaggt tggccgccgc gacggcaagg cggccaagca
3862321 ccacgtccgt ggcgtcgatg acgtaccacg atcgcgtggt gtcacccgcc ttgggcgcgt
3862381 acgtgggcac agcgcttacc ttcttttctc tcgggtggat cccggggtgc cccgggcgcc
3862441 ggtcaggcgt gaacggcggg ttggtctcgg cgaaccgaca ttgacccgag gtcccggcgt
3862501 accgcacgcc aaccgagcag cttaccgacg agcatccacg caggtcaaaa tgactgtgtg
3862561 gtcccgacgg ctctcccccg tcgggaccac acaggggtct gttgcgcgct ccggggcccg
3862621 gaactagcgt gcccaagctc cagccgcccg ccggtcggca tgcgccacgt cgtcggcacc
3862681 gtggcgaacc gcgtttccca agtcgatcag gatctcgttg agcgcgctgg ccgcctggtg
3862741 ccacttgagt tgctccgcgt ggtaggcggc ggccgcttcc cgtgtccaga gctgctgcaa
3862801 cggcgcgatc tgcgacctca gctcttgcag cgcagcgttg aaacgggccg cggtggtgtg
3862861 gatctcctga cgaacggagt attcgatggc gtcaaagttg tacgacaaca cggggtctgc
3862921 gttcatagtc gaggctgatc ctcggtctat aggtcgccgc cggcggcggc gatgtggcgg
3862981 gcatggattt ggccggcttc ccgcagcgcg gcctcgttgt ggcggatggt gtcggcgatc
3863041 gcgtgcagga cgtggtagag ccgcgtcgac tcggcgttcc agcgatccac cacatcctgg
3863101 aaccgagcgg ccgcgagccc accccacacc gacggcggca caccgctcat gcggccgatg
3863161 aatgcctgca gcatcgcacg gatttcctca ttgcgggcgt ccgtgatacc cgcaaccgaa
3863221 cgcatcaggt caaagtcggc gttcagcgtg ttcggtgtgc tcacatcaag taggaccgcc
3863281 gccaacctcg tctggttccc tccgatcctt cccggttcaa ccaacggcgt ggacggaccg
3863341 tacggcttgc gcacacacct ccctgaggag gtcttcatgg ccgggcccgc tctggcagcc
3863401 gacgctgatc cggaccgctc cgtcgagcag aatcgtccac cgcacctgat gcccggcgcg
3863461 gacctctcga taggtcaccg cgggccggcc ggctctgata tcggaggggt tgaagtcgac
3863521 gaataccccg gccggtgacg cgtcgatcgc ccgcttcaac cgctgcgcgg tgccaggcag
3863581 cgtctcaccg ggaaccggtg attgtgtgac gtgcaacgcc acctcgggat cggccggtga
3863641 agtgacctgt acccgcgccg aaccgggacc ggagaccacc cgctgcgtgg accagtccgc
3863701 cggaatcgtc agcgccaccc ggccctctac cagaagcgtc gtcggtggtc tttgcagggt
3863761 tgtcgcaccg tggcggacca cggcagccgg cgccagtaac gccaaggcga caccggcggc
3863821 cgcaacccgg gcaagtgtcg ggacccgaga gcgggtggca ggccgcgccg ccggatcggc
3863881 gggctcgtcg gaaggcggca gggcggccct ggccaaccgc gccagccgca cgccgtcgat
3863941 ctcgaccacg ctgctaccgg taccccgcac cgcaccggcg attgccgccg cgagcgctgc
3864001 cgccccggcg accgtactgg gcacgtcgat cagcaccacc gcggtaatac cccgcgtcat
3864061 ccgcgcaatg acactgccta cctggccggc aacggactcg gcgtccgtgc ggcgggccac
3864121 cgcggcgacc tcggcgccgg ccaccaacac cagtcgctcc gcgatctcca ccaccaccgt
3864181 tgcggccgaa acccccgagg acgcctgcct cagcagccac gaccgcgggt gcacgacgac
3864241 atcgcgggtc agcgtgcgtg cggctgcggt gaccacctcg acccgagccg ccgaccacca
3864301 cgacgggtgc acgacgaccg ggccgtcacg gtggtcgacg gccaccgatc gcagggcgtc
3864361 gaaccacagc gaatccacgg cgactggccg ttcgtccagc agcgctacct ggtcgtcgat
3864421 cgccgccagc gcggcggcag acactgcggt gtccgcgact acgtctgcgc cacaacacaa
3864481 tcggcggatg gcacccggac ccgcctcgat caccgcgcga tgtgggctca cgggggtggg
3864541 ctccaggcga cttgaaccag ttgctcgtca ccggcaccgg tgaccaggat gccccggccc
3864601 ggtggcagcg gcatcgggcg gctcgacccg aacagtgcgc cttcatccgg acgtccgctc
3864661 atcagcagtg cccggcagcc caggtcacgc aggctggcaa gcaccggctc gaacagcgcc
3864721 cgagcagcac ccccgctgcg ccgcgccacc accaggtgta aaccgagatc tcttgcgtgc
3864781 ggcaaatatt cgagcaagac catcagcggg ttgcccgatg agaccgcaac caggtcgtag
3864841 tcgtcgacca cgacatagat atccggaccc gaccaccagg acctggctcg cagctgcgcc
3864901 tggctcacat ccggggcggg catccgcgcc tggagcaggt cgaccagact cgacagcttg
3864961 gcacccagcg ccgccggcga gctgacgtag ccgctcatat gttccgactc gatgacgtcg
3865021 agcagggtgt gccggaagtc gacgatgaga agttgggctc gcgcggcggt atgggtccgg
3865081 acgatctcgc ggcacagggt ccgcaacgcg gccgtctttc cgcactcgtt gtcgcccagc
3865141 accagcaggt gcgggtggcg tccgaaatcg acggccaccg gctggcctcg acgttcctcg
3865201 aggccgagca agatgtgcgc accgagttcg tcgccggctc gggccacgac gctgtcgtag
3865261 tccacgcgcg cgggcagtag cggtatcggg ggcgccaccg gatcaccact tcggcgtcgt
3865321 agcgcaactc catccaggtc gggcagggcg atcaccatgt gcatcccgtc gcgggagagg
3865381 ccacggcccg gtctgtcgac cggcacccgt tgcgcctgcc tacggtccaa ttcggaatcc
3865441 gcgggatccg ccagccgtaa ctcgattcga ctgccgatct gatcccgcag cgacggcctg
3865501 atctccgccc accgtgctgc cgatagcgcc acatgtacgc cgaatgaaag cccttgagct
3865561 gccagggcaa cgatcgactc ctcaagggcc gcgaactcct ggcgtaagct tgcccagccg
3865621 tcgatgacaa gaaatatgtc cgcaaaagac tcagcggccg actttgctcg cagctggcgg
3865681 taccgcgcca ccgagtcgat gccgtggtcg cggaagaatg cctcccgaaa tcgcacggcc
3865741 gactccagtt cggcgagcat ccgcgatgcc agctgcggct gcgccctgcc ggccacggca
3865801 cccacatgcg gcagttcgtc cacctgggcc agcgccccgc cgccgaagtc caaacaatag
3865861 aactgcaccc ggcccgcatc gtgggtagca gccaacgcca tgatcagcgt ccgcagcgcg
3865921 gttgacttgc ccgtttgcgg tgcacctacg accgcgacat tgcctgcggc cccggacaag
3865981 tcgatcgtca gcggcacccg tgactgctcg aacggccgat cgacaatgcc gatgggtacg
3866041 gccagctcgg cctgcgccgg ctcagcgtca cgcagtaggg cgcccagcat cggtggctcg
3866101 tccagcggcg gtagccagac ttgatgcgca gccggtccat gaccgaccag ccggtcgagc
3866161 accgcatgca agacggtagg cgtgggcacc tcggctgtcc cgccgacggg accggctgtg
3866221 accggcgccg cagcgtgcgt ggtgaacggt cgcaccgacg gcggggctac cgggtggacc
3866281 gctgagggac tcgcccgtcg aagcggcccg gaaacgaacg cggtctgaaa tcggatcagc
3866341 tctccggttc ccgtttgcag caagcccgca ccgggggtgt tgggcagttg atatgcgtcc
3866401 tgcgtcccga gcacgttgcg tgattcactg gcggaccacg ttttcaggca cattcgatag
3866461 gacagatggg tttccagtcc acgcagtcgg ccctcgtcga gccgctgact ggccagcagc
3866521 aaatgcatgc ccagcgaccg gcccacccga ccgatcgcga ggaacacgtc gacgaattcg
3866581 ggatgttggc tcagcaattc ggaaaactcg tcgacgacga tgaacaggat cggcaggcag
3866641 ggaagttgcg cacccgtttg gcgtgcccgc tgatatgccg tgacactgac caagtggcct
3866701 gccatccgca gcagctgttg ccggcggctc atctcgccgg ccaatgcgtc ttgcatccgt
3866761 gcgaccagcg gtgcttcctc ggcaaggttg gtgatgaccg cggctacatg tggggctccc
3866821 gcgaggtcga gaaatgttgc accacccttg aagtcgacca gaaggaggtt gaggacttcg
3866881 ggcgaattgc gtgccatcat ccccagcgcg atggtacgca gcagctccga tttgcctgat
3866941 ccggtggcgc cgacgcacag cccgtgtgga cccatgccct gttccgcggc ttccttgatg
3867001 tctagctgca cggcggtacc gtcgggcgtg actccgatcg ggacacggag ccgatcatgt
3867061 tggtttacgt tgcgccacaa cgtgctcgga tcgaaagcgg ccacatcgcc gatgccgacc
3867121 agttccgccc aacccgagcc acggatgaac gtgcgacccg agtgcccgac ccggtgagcg
3867181 gccagccgac gggcgcatac cagcgcgtct tgaggctcca gctggtccgg gcacgctagc
3867241 gctgtcactt cgccggcaca tctgaccacc ggcggtgcac cgtctcgtct ggcgcccacc
3867301 tcgatcgtga tcacgccggt gatcgcgccg ttgccacgtt cggccgtgtc gacgatcgca
3867361 acaacgtggg ccaataccgt tgcggctagc gcattttgca tctctgccag ggtcgagtac
3867421 accatcgggg ctggccccaa ggcatcacag gcattcggat gttggttgtg cggcagccat
3867481 ttcagccaat cccagtgcgc gcggttgcgg tcactgacca cgccggcgat cagcaactcc
3867541 tccggtgagt gccatacggc cagctggcag atcatcgccc gcagcagccc gcggaccttg
3867601 gtcgggtcac cgtcgatggc gatcggaccg ccgacccgca aggggatcgc gatgggcgca
3867661 tccgcaatgg tcgcgtgtgc ggcaaggaaa cagcgcagcg cggcgcgggt gaccggatcc
3867721 gcacgctgcg ccggcggaag ctgcccgacc accaagcggg tggccagcgg tgcagatcca
3867781 actccgacac ggatgcgaca gaagtcggca gcacccggtc gacgctccca cattcgcgga
3867841 ccaccgatca atgtccacaa ggtggcagga tcgggatgcg tccagttcag tgatacgtgt
3867901 tgtgctgcag ccgtttgggt gacagatgtg cgcaagacac tcaggtaccc gaggtagtcg
3867961 acacggtcgt tgtggatacc ggagacatgc cgccggccgc gtccggttac cgcagtcacc
3868021 accaacgaga ccagcatcat cattgggaag gccagaaacg tggggtggcg cgtggccggc
3868081 gagcccggca agaacaccgt caccatgaca cccacggtcg ccaccgacat gacgaccggg
3868141 agcaggcgaa tcagcaggct ggacggttcc gaccgccgca actcgggcgg cggggcaacc
3868201 aggatgtccg cagtcgcgca cgccggccct gaattcatgc tgggcgacgg tatgcagcgc
3868261 gagaatccgc cgcaagtcgc ttgtggacaa ccgaataccg ggcgatcgag aaccggctac
3868321 cgttccggtg atccgagaat aaagggggag aatgcctacg tctgatccgg gactgcgccg
3868381 ggtcaccgta catgccggcg cccaggccgt cgacctgacc ttgcccgccg cggtgcccgt
3868441 cgcgactctg atcccgtcga tcgtcgacat cctgggtgac cgtggcgcca gcccggcgac
3868501 ggcggcgcgc taccagctgt ctgccctggg ggcgccagct ctgccaaacg caacgacatt
3868561 ggcgcaatgc ggtatccgcg acggcgccgt cctggtcttg cataagtcca gcgcccagcc
3868621 gcccaccccc cgctgtgacg atgtggccga agcggtggcg gcggcgcttg acaccacagc
3868681 ccggccccaa tgccagcgca cgacccggct cagcggtgcg ctggcggcaa gctgcatcac
3868741 cgccggcggc ggcctgatgc tggttcgaaa cgccctcggc accaacgtaa cccgctactc
3868801 cgacgccacg gccggagttg tagcggcggc cggcttggct gccttgctgt ttgcggtgat
3868861 tgcatgccgg acatatcggg acccgatcgc cggcctcacg ttgagcgtta tcgccaccat
3868921 attcggtgct gttgccggcc tactggcggt gcccggggtc cccggtgtcc atagcgtgct
3868981 agttgccgcg atggcggcgg ccgccacgtc ggtgctggca atgcgcataa cgggttgtgg
3869041 gggtatcacg ttgaccgcgg tggcgtgctg cgcggtagtc gtcgcggccg ctacgctggt
3869101 cggcgcgatc actgcggccc cggtgcctgc catcggttcg ctggccacgc tggcatcctt
3869161 tggtctgtta gaggtatccg cgcggatggc agtcctgttg gcggggttgt cgccacgatt
3869221 gccgcccgcg ctgaaccccg acgacgccga tgccctgccc accacggatc ggctgaccac
3869281 ccgagcgaac cgtgcagatg cttggttgac gagcctgctg gcggccttcg cggcctcggc
3869341 gaccatcggt gccatcggaa ccgccgtcgc aacccacggc atccacaggt ccagcatggg
3869401 cggtatcgcg ttggccgccg tcaccggtgc gctgctgctg ctacgagcac gttcagcaga
3869461 caccagaagg tcactggtgt ttgccatctg tggaatcacc accgttgcaa cggcatttac
3869521 cgtcgccgcg gatcgggctc tggaacacgg gccgtggatt gccgcgctga ccgccatgct
3869581 ggccgccgtg gcaatgtttt tgggcttcgt cgctcccgcg ttgtcgctct cgcccgtcac
3869641 gtaccgcacc atcgaattgc tggagtgtct ggcgctgatc gcaatggttc cattgaccgc
3869701 ttggctatgc ggcgcctaca gcgccgttcg ccacctcgac ctgacatgga catgaccacg
3869761 tcccgtaccc tgcgcctgct ggtggtatca gcgctcgcga cgctgtctgg gttgggaacg
3869821 ccggttgccc acgcggtttc gccgccgccg atcgacgaaa gatggctacc cgaatctgcg
3869881 ctgccggcgc cgccgcggcc gaccgtacaa cgtgaggtat gcaccgaggt caccgccgaa
3869941 tcgggacggg ctttcggccg ggctgagcgg tccgctcaac tcgccgacct cgaccaggtc
3870001 tggcgactca cccgcggcgc cggccaacgg gtcgcggtca tcgacaccgg cgttgcgcgc
3870061 catcgacggt tgcccaaggt ggttgccggc ggtgactatg tcttcaccgg ggacggcacc
3870121 gcggattgcg atgcacacgg cacgctggtg gccggaatta tcgcggccgc accggatgcg
3870181 caaagcgaca atttcagcgg ggtggcaccc gatgtcacct tgatcagcat tcgccagtcc
3870241 agcagcaagt tcgcaccggt cggcgacccg tccagcacag gtgttggtga cgtcgacacc
3870301 atggcgaagg ccgtgcggac ggccgccgac ctcggcgcgt cggtgatcaa catctcgtcg
3870361 attgcctgcg ttccggccgc ggctgcgccg gacgaccgcg cgctaggtgc cgctttggcc
3870421 tatgcggtcg atgtcaagaa cgccgtcatc gtggccgcgg ccggcaatac cggcggcgcc
3870481 gcgcagtgtc cgccgcaggc ccccggggta acccgggaca gcgtcacggt tgcggtgagt
3870541 ccggcctggt acgacgacta cgtgctgacc gtaggttcgg tgaacgccca aggcgaaccc
3870601 tcggcattca ctctcgccgg cccctgggtg gatgtcgccg ccaccggcga ggcggtgacc
3870661 tcgctcagcc cgttcggtga cgggaccgtg aacaggcttg gcggacagca tggttcgatt
3870721 ccgatatccg gaaccagtta tgcggcgccg gtcgtcagcg gcctggccgc cctgatccgg
3870781 gcccgctttc cgacgttgac cgcacggcag gtgatgcagc gcatcgaatc taccgcgcat
3870841 cacccacccg ccggatggga tccgctcgtc ggcaacggca cggtcgatgc cctggctgcg
3870901 gtcagcagcg actcgattcc gcaggccggc accgcaacga gcgaccccgc tccggtggcg
3870961 gtgccggtcc ctaggcggtc aacgcccggc ccatcggatc gccgcgccct acacaccgcc
3871021 tttgctggtg ccgcgatctg cctgctcgcg ctgatggcaa ccctggccac cgccagccgc
3871081 cggctacggc ccgggcgcaa cggtatcgcg ggcgactgac gcgttggctc tactcagctc
3871141 cggtccggac ggcagtgtcg ccaacaccgg ccacggcgcc gggatggcag ccgtcggcag
3871201 accgaggtcg tgtgccacgt cgtcgtcgtg gatcgcgaac cgcactccgg tgtcggtgac
3871261 caggtagcgc gtgccggtgc cgccgccgga caggctgcgc gcggctacgt aggcgctgcg
3871321 tcccggcggc aggtacaccg cgtccagtgc ggggccgcga ccgtcggctt gtgccagtgt
3871381 caccggaacc cctccgaggg gcaccggcgg gccgctgccc gccaagaacg cgacgcgagc
3871441 agcacccggc tgcgcgggcg tccaggtcac gcacaacgtg gtgaccgccc ttcccggcga
3871501 gccgtccacc ggtgttggcg gccggtcggg aaaggccgac accggcaagg tgttcacgat
3871561 cggagcgacg cgaatcacat cgggggccac cgtcgggacg ttgacgctgc cctgcgaatc
3871621 gccgaaccgc aacaaatccg cggcgacctg gccgatgcgc tgcacgccgt cctccagcac
3871681 cacgtaatac tcatcaccgc tcgcgcgagt gatgcgcacc acaccgccga ccagaaaccc
3871741 gggcagcccg accgaggccc gcccgccgcc acgaatccgg ggagccgtga tgcgcggtgc
3871801 ctccgggacg gcgttgagca acgattgcgc gaccacgtgc gggacccggc cctgcagccg
3871861 cagcgcccac accaccgccg ggtcggccag atccaccacg gcccgccgac cgccgtagag
3871921 caggtaggtg ggcgaacctg attcggtcgc caccaggatc atctgttcgg cggtcagcac
3871981 ctgcgccgac gagtcttcgg cgggcccgac gacgacagtc gttgatccgc cattgtcgct
3872041 atcgcagatc gcccacgccg attcggcgcc ggctagcggc tggtcaagca gctgcggcgc
3872101 acctggaata ccgagcagtg gaccgcgttt ggtgtggccc aattcggact cggacaccgg
3872161 ttgcgggttg gcgttcgtcg ccgcgatcaa ccgcgccgaa gccaggttca acaccggatg
3872221 ccagacatcg tccactcgca cgtagagtgc cccggattcc cgacccatca cgatcggcgc
3872281 ctgaccgagc gccgactgtg gccgcagcag cgcaacgaat gcgcatccca tcgcggcgac
3872341 gatcgccagc acgcacccga gggccagcga tgttgtgcgc gcgcgcagtg ctccggtcgc
3872401 tgcgcagaca tccccgaaca gcaacgcgca ctcgatgcgc cgcagcagaa atcggtaccc
3872461 gctgacgtgc agccaggtcg tcgctgggct cggcactggc tctcccacgg tggcgcgctg
3872521 atttctcccc acggtaggcg ttgcgacgca tgttcttcac cgtctatcca cagctaccga
3872581 catttgctcc ggctggatcg cgggtaaaat tccgtcgtga acaatcgacc catccgcctg
3872641 ctgacatccg gcagggctgg tttgggtgcg ggcgcattga tcaccgccgt cgtcctgctc
3872701 atcgccttgg gcgctgtttg gaccccggtt gccttcgccg atggatgccc ggacgccgaa
3872761 gtcacgttcg cccgcggcac cggcgagccg cccggaatcg ggcgcgttgg ccaggcgttc
3872821 gtcgactcgc tgcgccagca gactggcatg gagatcggag tatacccggt gaattacgcc
3872881 gccagccgcc tacagctgca cgggggagac ggcgccaacg acgccatatc gcacattaag
3872941 tccatggcct cgtcatgccc gaacaccaag ctggtcttgg gcggctattc gcagggcgca
3873001 accgtgatcg atatcgtggc cggggttccg ttgggcagca tcagctttgg cagtccgcta
3873061 cctgcggcat acgcagacaa cgtcgcagcg gtcgcggtct tcggcaatcc gtccaaccgc
3873121 gccggcggat cgctgtcgag cctgagcccg ctattcggtt ccaaggcgat tgacctgtgc
3873181 aatcccaccg atccgatctg ccatgtgggc cccggcaacg aattcagcgg acacatcgac
3873241 ggctacatac ccacctacac cacccaggcg gctagtttcg tcgtgcagag gctccgcgcc
3873301 gggtcggtgc cacatctgcc tggatccgtc ccgcagctgc ccgggtctgt ccttcagatg
3873361 cccggcactg ccgcaccggc tcccgaatcg ctgcacggtc gctgacgctt tgtcagtaag
3873421 cccataaaat cgcgtcatga ggttcatcgg ggtgatccca cgcccgcagc cgcattcggg
3873481 ccgctggcga gccggtgccg cacgccgcct caccagcctg gtggccgccg cctttgcggc
3873541 ggccacactg ttgcttaccc ccgcgctggc accaccggca tcggcgggct gcccggatgc
3873601 cgaggtggtg ttcgcccgcg gaaccggcga accacctggc ctcggtcggg taggccaagc
3873661 tttcgtcagt tcattgcgcc agcagaccaa caagagcatc gggacatacg gagtcaacta
3873721 cccggccaac ggtgatttct tggccgccgc tgacggcgcg aacgacgcca gcgaccacat
3873781 tcagcagatg gccagcgcgt gccgggccac gaggttggtg ctcggcggct actcccaggg
3873841 tgcggccgtg atcgacatcg tcaccgccgc accactgccc ggcctcgggt tcacgcagcc
3873901 gttgccgccc gcagcggacg atcacatcgc cgcgatcgcc ctgttcggga atccctcggg
3873961 ccgcgctggc gggctgatga gcgccctgac ccctcaattc gggtccaaga ccatcaacct
3874021 ctgcaacaac ggcgacccga tttgttcgga cggcaaccgg tggcgagcgc acctaggcta
3874081 cgtgcccggg atgaccaacc aggcggcgcg tttcgtcgcg agcaggatct aacgcgagcc
3874141 gccccataga ttccggctaa gcaacggctg cgccgccgcc cggccacgag tgaccgccgc
3874201 cgactggcac accgcttacc acggccttat gctggcgccg gaccccgccc gccaggcgcg
3874261 ccgcccgtca acgcagccga atgcgcattt gtccgccgaa tgcgccgcga tgaaccgcaa
3874321 tcatttcacc ggaagggaag tgtgcggaca cgctaaccgg acgctcgggc taacttcgac
3874381 cgctattgcg ctgaggaggg ttgatgccgg gcgtcataac aaacagtgaa agcccaaccg
3874441 cagccgacca cgacagaatt acggccacca gagagacgct ggaggattac acactgcggt
3874501 tggcgccgcg cagctatcgc aggtggcccc cggcggtggt gggcatctcc gctctcggcg
3874561 gcatcgccta cctggcggac ttcgcgatcg gcgccaatgt cggtatcacg tggggtaccg
3874621 cgaacgcgct gtgcggaatc gcaatcttcg cactggtggt cttcgtcacc ggcttgccgc
3874681 tggcctacta cgcggcgcgg tacaacatcg acctggatct gatttacccg cggtagcggt
3874741 ttcggctact acggctcggt ggtcaccaac gtcatctttg ccacgttcac gttcatcttc
3874801 tttgccctgg agggctcgat catggctcag ggccttaagc taggcctgca cattccgctg
3874861 tgggcgggtt acgcgtgctc gaccctgatc atcttcccgc tggtggtcta cgggatgaaa
3874921 gttttgtcac agctgcaact ttggaccacc ccgctctggc tgatcctgat ggcggcccca
3874981 tttggctacc tggtagtcag ccatcccgat tcgattggac agtttttctc ctacgccggc
3875041 aaggatggtc atggcggcct tagcttcggt tctgtcctgt tggcagcggg agtgtgcctg
3875101 tcactcatcg ctcagatcgc cgagcagatc gactacctgc gcttcatgcc gccacggacg
3875161 ccggagaacg cgaacaggtg gtggacgtgg acgctgctgg ccggtcccgg ctgggttgca
3875221 tttggggcga ccaaacagat catcggcctg ttcctggcgg tctatctgat ggccaacatc
3875281 cccggctcgt cgacaatcgc caaccagccg gtgcaccaat tcatgcagat ataccgcacc
3875341 ttcgtaccgg gctggctggc gttgacactc gccgtcatcc tggtggtctt gagccagatc
3875401 aagatcaacg tcacgaacgc gtattcgggc tcgctggcgt ggaccaattc attcacacgg
3875461 ctcaccaagc actatcccgg gcgggtcgtg tttcttgggg ttaacctcgc gattgcgttg
3875521 attctcatgg aagccaacat gtttgacttc ctgaacacaa tcctgggttg ctacgccaat
3875581 tgcggtatgg cctgggtggt ggcggtggcg tcggacatcg gcttcaacaa gtatctgctc
3875641 ggcctgtcgc cgaagactcc cgaattccgc cgcggcatgc tatacgccat caacccggtc
3875701 ggcttcgggt cgttgctgct ggccgcgggg ctgtcgatcg tcaccttctt cggcggtctg
3875761 ggtgcggcac tgcagcctta ttcaccattg gtggcaatcg tcaccgcgtt ggtaatgccg
3875821 cccattctgg cagccgcgac caaaggcaag tactaccttc gccgcacgca cgacggtatc
3875881 gatctgccca tgtacgacga gcacggcaat ccctcggccg cggtgttgac ttgccatgtc
3875941 tgccaccagg atttcgagcg gcccgacatg ctggcctgcc agacccatgg tgcgcatgtc
3876001 tgttcgctgt gcttgtccac ggacaagcag gccgagcatg tgcttcctgg gttagcccga
3876061 gcgcacatcc cgggtgacca agttccgtga cgcgagctgg tcatcgggcg gatagtccac
3876121 ctggatcaac gtcaacccgt gcgccggcgc gaccgcgaag tcgctggatc gtcctgtcgc
3876181 ggtgagcagc tcacgacacc aagttgtcgc gcgacggtgc tcgccgaccg ccagtagcgc
3876241 ccccaccaac gaccgcacca tcgaccaaca gaacgcgtcg gcggtgacgt gcgcggtgac
3876301 cagggtgccg gcacgcgacc agtccagccg ctgcagatca cgaatcgtgg tggcgccctc
3876361 gcgatgacgg cagaacgccg cgaagtcgtg cagccccatc aaatctcgcg acgcggccgt
3876421 catcgcatcc agatcaagct cgcgtggcca agcggtgatg tagcgcgcct gctgcggctc
3876481 gacaccgtag ggtgctgtcg acagccggta cacgtaatgc cgccgcagcg ccgagaatct
3876541 ggcgtcgaaa cccgctggtg cgcgcgtgat atcgaggatt cgaacgtcgg cgggcagaaa
3876601 tcgacccagc ctccgcaaca gcggcaggaa ttccggatca ccgacgtggc cggcgcgcgg
3876661 gtaagcgttc ggcaaggcat cggcgggcac gtcaacgtgg gcgacctggc cgctggcgtg
3876721 cacgcccgca tcagtgcgtc cggccgcccg cagccgcacc ggggtgcgga agatggtagt
3876781 cagcgccgca tcgagatcgc ccgcgaccgt gcgctgcccc acttgtgcag cccagcccgc
3876841 gaaatcggtt ccgtcgtagg cgatatcgag ccgaagacgg acaacgccgc taattctcgg
3876901 gggcctctgc ggggggctct tcgggggcct tcgcgtcagg ctcactggcg ccgaccacgt
3876961 caccctcctc agcaggcttg gcctcggact cctcggtcgg catggccgcc gccttcttgg
3877021 ccttcgcctg cgcggcagct acccggcgtg ctcgattggc ctccgaggtc accgtcttct
3877081 cccggaccag ttcgatcacg gccatcggag cgttgtcgcc cttacgtgcc tcgattttga
3877141 tgatacgggt gtagccacca tcgcggtcgg cgaagaacgg tccgatctcg gcgaacaagg
3877201 tatgcaccac atccttgtca cggagcttct tgagcacctc gcgccggttg tgcaacgcgc
3877261 cttttttggc atgcgtgatc agcttctccg cgtacggacg cagcgcccgg gccttcggct
3877321 cggtcgtcgt gatccgccca tgctcgaaca gggacgtggc gaggttggcc aagatcgcct
3877381 tctgatgtga agacgacccg ccgaggcgag ggcccttggt aggcttgggc atagctgacg
3877441 ctcctgtctg gattagaggc agtctaaagc tgttcggttt cggcgtagtc ctgctcgtcg
3877501 tacgcgccct cggtcgacca ggtgccggtg gcgacgtcgt agcccgcgac ctccgagggg
3877561 tcgaagctcg gcgggctgtc cttgagtgac aggcccagct ggtgcagctt gatcttcacc
3877621 tcgtcgatgg acttctgacc gaagttgcgg atgtcaagca ggtcggattc ggtgcgcgcc
3877681 accagttcgc ccacggtgtg caccccctcg cgcttgaggc agttgtagga ccgcaccgtc
3877741 agatccaggt cgtcgatcgg cagggcgaat gacgcaatgt gatcggcctc ggccggcgac
3877801 ggcccgatct cgatgccttc ggcctcgacg ttgagttccc gtgccaggcc gaacaactcg
3877861 accagcgtct tgccagccga cgccagcgcg tcgcgcgggc tgattgaatt cttggtctcc
3877921 acgtccagga tcagcttgtc gaagtcggtg cgctgctcga cccgggtggc gtccaccttg
3877981 taggtcactt tgagcaccgg tgagtagatg gaatcgactg gaatgcgccc aatttcggca
3878041 cccgaagccc ggttttgcac cgccgggaca tagccgcggc cacgctcgac gacgagctcg
3878101 acttccagct tgcccttatc gttcagcgtg gcgatgtgca tgccggggtt gtgcacggtg
3878161 acgccggccg gcggcacgat gtcgccggcg gtaacctcac ccggaccctg cttgcgtagg
3878221 tacatggtga ccggctcgtc ctcctccgag gacaccacca ggctcttgag attcaggatg
3878281 atctcggtga catcttcttt gaccccgggc accgtggtga attcgtgcag tacaccatcg
3878341 atgcgaatgc tggtgacggc cgctccggga atcgacgaca gcagggtgcg acgcagcgaa
3878401 ttgcccaggg tgtagccgaa tcccggctcc agcggttcga tcacgaactg ggatcggttg
3878461 tcggtgagga cgtcctcgga cagggtgggg cgctgtgaga tcagcatggt gtttcttctt
3878521 cctttcgacg tccgccatat gacgtctgtg ggggcactcg ggggcggcgc ccccgagggt
3878581 gggggtactc ggggggcggc gccccccgag ggttgggttg gggggtactc ggggggcggc
3878641 gccccccgag ggttgggttt actttgagta gtactcgacg atcagctgct cggtgagtgg
3878701 gacgtcgatc tgcgcgcgct cgggtagctg gtggatcagg acgcgttgcc gctcccccac
3878761 cacttgcagc cagctcggga tcggacgctc gcccgccgtc tcccgggcaa tctggaacgg
3878821 caccgtgttc agggacttgt cccgcacgtc gacgatgtcg tactgcgaca cccggtaact
3878881 ggggacgttg acgtgcacgc cgttgacgtt gaaatgcccg tggctgacca gctggcgagc
3878941 catccgccgg gtgcgcgcca gcccggcacg gtagatgacg ttgtccagcc ggctttcgag
3879001 gatcttcagc agttcttcac ccgtcttgcc gggctgccgc acggcctctt cgtagtagcg
3879061 gcggaactgc ttttccatta cgccgtatgt gaaacgggcc ttctgcttct cctgcagctg
3879121 aagcagatat tcgctttcct tgatccgcgc gcgaccgtgt tggccgggcg ggtagggacg
3879181 cttctcgaag gcctggtcgc caccgacgag gtcggtgcgc aaccgccgtg atttgcgggt
3879241 gacgggtccg gtgtaacgag ccatcttctc tcctagacgc gccggcgctt ggggggccgg
3879301 acaccgttat gcggctgggg ggtgacatcc gagatcgcgc ccacctccag gccggcggcc
3879361 tgcagcgacc ggatcgcggt ctcgcggccc gagcccgggc ccttgacgaa cacgtcgacc
3879421 ttgcgcaccc cgtggtcttg ggccttgcga gcggcgttct ccgcggccag ctgggccgca
3879481 aacggggtcg atttccggga acccttgaag ccgacgtgcc ccgacgatgc ccaggcaatg
3879541 acgttgcctt gcgggtcggt gatggtcacg atcgtgttgt tgaacgtgct cttgatgtgg
3879601 gcggcgccgt gcgggacgtt cttcttctcc cgccggcggg tcttctggcc cttcctagcc
3879661 gacgttgccg gccctttttt tgctggtggc atcggttacc tagccttctt cttgcctgcg
3879721 atggtgcgct tggggccttt gcgggtccgc gcgttggttt ttgtccgctg gccgcgtacc
3879781 ggcataccgc ggcggtgccg caacccctga tagcagccaa tctcgatctt gcgacggatg
3879841 tcggcctgta cctcgcggcg caggtcaccc tccaccttca ggttcgcttc gatgtagtcg
3879901 cgcaggtgga tcagctgttc ttcggtgaga tctctggtgc gcagatcccg gtcaatgccg
3879961 gtggccgcca ggatttcgtt cgagcgggta cggccgatgc caaagatgta ggtcagggcg
3880021 acctccatcc gcttatcgcg cggcaggtcg acgccgacga gtcgagccat aggtggcgtt
3880081 tcctcttcct ctgcggaggt atggtcccag tccgttccct gcccaaaaaa gatctttggg
3880141 tgtggggccc ggcctccgtc cgggcgtgaa tgagctggcc catctccatc gatgccagcc
3880201 gctcattggt gctgggggtc tgcatttagt tgtcgggccg tccggctcct cctcggacca
3880261 ctacgcggcc cgcatcgtcg ccgaactagc cctgcctttg tttgtgacgc ggatcggaac
3880321 agatcaccat aacccgcccg tgccgacgga tcagcctgca cttgtcacag atcggcttga
3880381 cgctcgggtt taccttcacg actgtctcgg tcctgttcta tgggtatgtc gctacttgta
3880441 ccggtacacg atgcggcccc gggacaggtc gtagggcgac aattccacca ccacccggtc
3880501 ctcgggcagg atgcgaatgt agtgctgacg catcttgccg ctgatgtggg cgagcacctt
3880561 gtggccgttc tccagctcaa tgcggaacat ggcattgggc aggggctcga ccacgcgacc
3880621 ctcgacctct atggcaccgt ccttcttggc cattactttc tggcgatcct tctcttcctt
3880681 gtcggtgcac ccgattccgg cgcagcacgt gctcggacta caaacgtgag ccggtggtgg
3880741 aaattccgcg aagggctccg agaaattttc aaaactgggc acgccaaacc ggcacgggac
3880801 accgcaccgc caacccacat tacccgcatc gccgtgctct gcgcaaaacg ccgtaggcca
3880861 cgcgctcacc ggaatagcac cggtgagccg agcggttaga gcaaccatga ccaattgtgc
3880921 cgccggcaaa cccagctcag gccctaacct cggccgattc ggatcgttcg gacgcggcgt
3880981 caccccccag caggccacag aaatcgaggc gctgggctac ggggcggtct gggtgggagg
3881041 ctcaccaccc gccgcactgt cctgggtgga accgattctg caagcgacca ccacattgtg
3881101 tgtggccacc ggcattgtca atatctggtc ggcaccggcc cagcgagtcg ccgaatcgtt
3881161 ccaccgcatc gaggcggcct acccgggccg ctttctgctg ggtatcggag tcgggcatgc
3881221 cgagatgatc agtgagtacc gcaagcccta caacgcgctg gtggaatacc tagaccggct
3881281 cgacgactat ggggtgcccg ccaaccgccg ggtggtggcc gcactgggcc cccgggtcct
3881341 gggcctgtcc gcacgccgca gcgccggggc gcacccgtac ctgaccacac ccgaacacac
3881401 ggcacgggcc cgtgagctga ttggtccgtc ggcgttcctg gcgcccgaac acaaggtggt
3881461 gctgaccacc gactcggcaa gggcccgtac ggtgggacgc caggcgctcg atatgtactt
3881521 caacctggct aactaccgca acaactggaa acggctgggc ttcaccgacg acgaagtctc
3881581 ccggccgggc agcgaccgcc tggttgacgc cgtggtcgcc tacggcactc cagacgcgat
3881641 cgcggcacgg ctgaacgaac acctgcttgc aggcgccgac catgtcccta ttcaggtcct
3881701 caccgaagat gacaacctgg tgtcggcgct gaccgaactc gcgaagccgc tccgactgac
3881761 ttgatcccga aacggagggt tgcgaaccca actggtcgcg gctccactcg gttaaggctc
3881821 ggttagggtt tgatccatgc ggttgctagt caccggtggc gcgggattca tcggcacgaa
3881881 tttcgtgcac agcgccgtac gtgagcatcc agacgatgcg gttaccgtac tcgacgccct
3881941 gacctacgcc ggccggcgcg agtcgctggc cgacgtggag gatgccatcc ggctggttca
3882001 gggcgatatc accgacgccg agctggtttc gcagctggtg gccgagtccg acgcggtggt
3882061 gcattttgcc gccgaatccc atgtcgacaa tgcactggac aatccggagc cgtttctgca
3882121 caccaacgtc atcgggacct tcaccatcct ggaagcggtg cgacgccacg gtgtgcgcct
3882181 gcaccacatc tccaccgacg aggtctacgg cgacttggag ctcgacgacc gggcgcggtt
3882241 caccgaatcg acgccctata acccgtccag cccttactcg gcgaccaagg cgggcgcaga
3882301 catgttggtc cgggcctggg ttcggtccta tggcgtacgc gcgacgatct ccaactgctc
3882361 caacaactac gggccgtatc agcacgtcga gaagttcatt ccgcgtcaga tcaccaatgt
3882421 gctcaccggg cggcggccca agctctacgg cgcgggcgcc aatgtccgtg actggatcca
3882481 cgtcgacgac cacaacagcg cggtgcggcg aatcctggac agaggccgca tcggccgaac
3882541 ctacctgatc agctccgagg gcgagcgtga caacctgacc gtgctgcgca cgctgctgcg
3882601 actgatggac cgcgatccgg acgacttcga ccacgtcacc gaccgcgtcg gccacgacct
3882661 gcgctatgcc atcgacccgt ccacgctcta cgacgaatta tgctgggcgc caaagcatac
3882721 cgatttcgag gagggcctgc ggaccacgat cgactggtac cgcgacaacg aatcgtggtg
3882781 gcgtccacta aaagacgcca cggaggcccg ctatcaagaa cgcggtcaat gagatgaaag
3882841 cacgcgaact cgacgtcccc ggcgcctggg agattacccc gaccatccat gtcgattccc
3882901 gcggactgtt cttcgaatgg cttaccgatc atgggttccg cgcattcgca ggtcacagtt
3882961 tggacgtccg gcaagtgaac tgctcggtgt catcggccgg tgtgctgcgc ggcctgcact
3883021 ttgcccagtt gccgccgagc caggccaagt atgtgacctg cgtttccggc tcggtgttcg
3883081 atgtcgtcgt cgacatccga gagggctcac cgacattcgg ccgatgggac tcggtgctgc
3883141 tcgacgacca agaccgtagg acgatctacg tctccgaagg cctagcgcac ggcttccttg
3883201 cactgcaaga caattcgacg gtgatgtact tgtgctcggc ggaatacaat ccgcagcgcg
3883261 agcacaccat ctgcgccaca gatccgacgt tggcggtcga ttggccgctg gtcgatggcg
3883321 ctgcccccag cctgtccgac cgtgatgccg ctgcgcccag cttcgaggat gtgcgcgcgt
3883381 ctggcctgct gcccaggtgg gaacagacgc agcggttcat tggggagatg cgcggcacct
3883441 agctcggtaa tcccttgtgt tgctttagct tcagcggtca cagcgcggcg attgttgtcg
3883501 gtggcccctc gtagaatttg gggtatgggt tcgggtagcc gcgaacggat tgtcgaggtc
3883561 tttgatgcgc tggatgccga gctggaccgc ttggacgagg tgtcttttga ggtgttgacc
3883621 accccagaac ggctgcggtc tctggaacgt ctggaatgct tggtgcgccg gctaccggcg
3883681 gtgggtcacg cgttgatcaa ccaacttgac gcccaagcca gcgaggaaga actgggcggc
3883741 acgctgtgct gcgcgctggc caaccggtta cgcatcacca agcccgacgc cgcccggcgc
3883801 atcgccgacg ccgccgatct cggacctcgt cgagcactca ccggtgaacc gctagcccca
3883861 cagttgaccg ccaccgccac cgcccaacgc cagggcctga tcggcgaggc gcacgtcaaa
3883921 gtgattcgcg ccctttttcg cccacctgcc cgccgcggtg gatgtgtcca cccgccaggc
3883981 cgccgaagcc gacctggccg gcaaagccgc tcaatatcgt cccgacgagc tggcccgcta
3884041 cgcccagcgg gtcatggact ggctacaccc cgacggcgac ctcaccgaca ccgaacgcgc
3884101 ccgcaaacgc ggcatcaccc tgagcaacca gcaatacgac ggcatgtcac ggctaagtgg
3884161 ctacctgacc ccccaagcgc gggccacctt tgaagccgtg ctagccaaac tggccgcccc
3884221 cggcgcgacc aaccccgacg accacacccc ggtcatcgac accacccccg atgcggccgc
3884281 catcgaccgc gacacccgca gccaagccca acgcaaccac gacgggctgc tggccgggct
3884341 gcgcgcgctg atcgcctccg ggaaactggg ccaacacaac ggtcttcccg tctcgatcgt
3884401 ggtcaccacc accctgaccg acctgcaaac cggcgccggc aagggcttca ccggcggcgg
3884461 caccctgcta cccatggccg atgtgatccg catgaccagc cacgcccacc actactcccc
3884521 cgcaagcggg aggtaccccc aggcgatctt cgaccacggc acacccctgg cgctgtatca
3884581 caccaaacgc ctagcctccc cggcccagcg gatcatgctg ttcgccaacg accgcggctg
3884641 caccaaaccc ggctgtgacg caccggccta ccacagccaa gcccaccacg tcaccgcctg
3884701 gaccagcacc ggacgcaccg acatcaccga gctgaccctg gcctgcggcc ccgacaaccg
3884761 actcgccgaa aaaggctgga ccacccacaa caacacccac ggccacaccg aatggctacc
3884821 accaccccac ctcgaccacg gccaaccccg caccaacacc ttccaccacc ccgaacgatt
3884881 cctccacaac caagacgacg acgacaaacc cgattgaccc ccagcagtca aagccacacg
3884941 ccacaacgcc gcacaaccat aaacaccgag tccgtcaggg cctggccgga gcaaacacgc
3885001 cacggtggta ggagctgtgg gcatatgcct tggagcccac cagttgtgac aacggcgtgt
3885061 gcaccgactg cccgcgtgcg agtctggcgg cgaccgcgtt taggtcgaac cgcggacgcc
3885121 agttcaagtc acggcgagcg cgggagttaa cgtacacgcg gtcgaggcgg tcggggaagc
3885181 gccaaccacg ctgggtccac acagccgcgg ccagcggtac ccgccgggcg aacaccgatg
3885241 ccgcgtcggt gcgcagctgc gtcaggtcat cacgggtaaa cggtgtggtc gccgacacca
3885301 gatagcgccc gaaccccagc tggggagctc gctgcgcggc gttgaggtgc gcatctaccg
3885361 cgtcttcgag cgcgacccgc cggcaggcat attcgttggc tttgatgttg tcctggctgc
3885421 gcccgtcata caggtcaggc atgtcatcgc cctcgacgaa gaatcgggca acacgcagca
3885481 cgacgcaggc caaaccgtcg ttgcgatgtg ccaactggca gaggtcctcg gagctagctt
3885541 tggtcacgcc gtagatgttc ttgggaatgg gcgtgacgga ttcgtcgatc cacgccgcgg
3885601 gctggtctgc cggcggtgtc agggcgtcgc cgaaaacggt cgtcgatgat gtcatgacga
3885661 aggcgcggac gttggcggcg accgcagcat ccagcacggt ctgggtaccg atgatgttcg
3885721 tgtccagaaa cgcctgacgc ggcaggaagg ccagttgcgg cttgtgatgg gcggccgcgt
3885781 ggaacaccac ctcaacgccg gccatcacgt ctcgcagcag tgctcgatca ctcacgcagc
3885841 caacgatatt cgtgtaccgc gacggtctgc tgtcgaggct gacgatgtcg gcgccccgtg
3885901 cacgcagagt gcgcaccagc gcctcgccca ggtgaccgga gctgccggta accagggtac
3885961 gcatcccgct ctcggcggcg gcagccgtcg gaggcgtgcc cgcgtgcaac aacagcggac
3886021 tggaccgcac gccggcgcgg actctcatgg tggctgcatg tgttcccacg actcacgccc
3886081 tcattcccac gaccactcga tcgatgtctt gcggggacaa ccactgcccc gcatgacttt
3886141 tcgcggtctg ccgaataacg tgggacacgg aaagccccgc ctgttgggcc gctgcgcgga
3886201 ggtgctcgac ctgcagcgaa tcgagtccgt ggaatccgaa cgagatctcc cacggatcga
3886261 tgccgtaact ctgcgggctc cggcccaaca tatccgatcg cgctgcgtcg aaaatccgat
3886321 ccaggtcgac tgccgccagg tgcccgcgcc gctgcaacgc ggcgacgagg cactcgatct
3886381 ggcaattccc ggccccgcga ccgaaaccca tcagcgttcc atccaggaaa tcggccccgg
3886441 cgtcgaatgc ctccaaggtg ttggcgacgg ccatggcgag gttgttgtgc ccgtggaagc
3886501 cgacggagac atcgctggca ccgcggagag cctcgacgta gcggcgcgcg tcctcgggca
3886561 ggaaggttcc cgtcgtatcc accacgtaaa cgatccggac gcccacatcg cgggcccgct
3886621 tcccggcagc agcaagcaca tcgggctcga agagatgcga cttcaccagc tggatcgaaa
3886681 cctccagacc ttttgactgc gcacgctcga cgaacggcat caccaactca aattcggtgg
3886741 cgatgacaca tatgcgcaga aagtccagat agtctccggc caaatcgacc gtctcgatgc
3886801 gggccagggc cggcacgatc acggcaccaa gtctcgcgtt tcgaaccacc gatcgggcgg
3886861 cgcggaaata ttcttcgtcg gtgtgagccg ccgggccctg cgccgcggcg gctccgatgg
3886921 tgacgccgtg accgatttca atgtagggaa ttcccgctgc gtcgagatcc ccgacaatcc
3886981 tgcggacatc gtcgtcggtg tactggaagt tcaccgcata gctgccgtca cggacggtcg
3887041 tgtccaggac aatcggctct ctgtgggtcg cagtcatgag catcagtgtc agcccgcacc
3887101 cttgccggat ccttgatgaa ttcttggacg cgcggctggt gtcctatcga cccagtccaa
3887161 tgtcgggttt gttgatctct ggatcgatcg cgatatcgag gacgcaggga ccggtggcgg
3887221 ccaacgcttt ttgcacaccg gcgcgcagct cgcagcgcgt atcgacccga atcccttccg
3887281 ctccaagggc gcgggccatc gccgccagat cgttcgcgcc gatgcgagcg accggcgacg
3887341 gatccatccg cccgctgacc gggccggcgc tggcactcat ttgtccgtcg ttgaggacag
3887401 cccaggtcac cctgatcccg tgcgcaaccg cagtggaaat ctccgtgcca tgcatcaaga
3887461 aagccccgtc cccggcgatg catatgacgt gttcttccgg tcgagccagg gccacgccaa
3887521 tggctccggc gatgccgcat cccatgggcg aaaagtcaac ggtggcaaag aatctgccgg
3887581 gccgccgcac cggtatccca cgaaacgtcc aagaaatgca ggtacccacg tcggcgcata
3887641 tcgtggcgtt gggtgcaagc tcgcggtcca gttcgtgcat cagctcaagc gggtgaatcg
3887701 attccccccg cgcttgcggg gtccccggca acgccgctgg cgccggcggc cgcacgccca
3887761 ccctccgaca aaagcgtggc ggccgcccgc agttcagggc attgacgaac gcgcgcccgg
3887821 acgtggtgat cccgagcgac gtagcgacga atcggccaac tgccgatgga tcgggatcga
3887881 catggacgac gtcggctttc agcccgcgcc agcggggcga aaaggagcgg gtaaccaacc
3887941 cgccgaagga aacaccgacc gcgatcaaca ggtcgcacgg tgtgtcgaag aggtactcgt
3888001 cggccctgcc gtcaccaaat atgccgagca cacccagaga cagcggatgg gtttccgcga
3888061 cgatcccccg cccgttcggt gtggtcgcaa aaggaagtcc cgccttctcg caaaacgcga
3888121 cgatctgctc gccgatgccg tccagccggc agccattccc cagcacgagc atgggggcac
3888181 gcgaccgatc cagcctaccg atcacctcgt cagcgacatc aggaccgcac ggcgccaggg
3888241 ttcttaggcc cccaagaccg gccgcggcag ttccaagttg gtgagccggc agccgctcgt
3888301 ccactagatc gcgcggcaga gcaatgtgca ccggtccgcg agggatgctc gccaaggccc
3888361 ggaacgccga atcgatcttg ctgcgcgcat tggcgatcga ttcgatggac accgaacagc
3888421 ggcagaaccg gcggaaggtt gcgcccaggc ccagtccgtc gtcgctcgta tcctgctgcg
3888481 agtgcaggcc gaattctccg accgccacct ccccggtcag gataagcatc ggaacctgat
3888541 tcaccgacgc attggccacg gcgctaatga cgttggtcgc cccaggtccc gccacaaaca
3888601 ccgcagcgga cttgccggac gcgcgggcga acccgtcggc caggtagccg gcgccgccct
3888661 cgtgccgggc caacacgatc tgaaagccgg catcgcggga cagacgcacc agcaacgaat
3888721 cgagccggga agtcggtagc ccgcatacga ccgaaatgcc ggctgcgcgc atcctggcga
3888781 cgagatgatc cccgacggtc acgggagtca cggccatgcc ccgatcacgg cggcctcgcc
3888841 catgcgctga tcgcgttccg gtaggtaggc cgggccgcag gcgcacaaga atgtcaacgg
3888901 aactgaacct agggcccgga ttttctgcgg gacaccagcc ggtatccaga ccgcatcgcc
3888961 gggcccgacc tcgccagatt cgtctccgac cgaaaccagc ccgcgccccg agagaacaaa
3889021 atagatctca tcggtggctt gcaatcggtg ccatacggtc tcggctcccg ccgccacggt
3889081 cgcatgggcc agactgaccg aggcgacgcc cacagtggcc cgatccacca ggacccgaat
3889141 ctcggacaag tccggcgcca cgaacggctc tgcctccctg gcgttgctga cgaacatggc
3889201 agcagcgtgt gcccgcgctc ttggcggatc cttgacgaat cctcggaacg cgggtttgtg
3889261 accggcggag agcgcgacgg ttgcctgcag cacagcgtct gtcgacgttg acgctcgctc
3889321 ccgttcgggc cgggttgaca tcccccacca ccggccacac aatgcgcccg gtggatgagc
3889381 agtggatcga gatactcagg atccaggcac tgtgtgctcg gtactgtttg acgatcgaca
3889441 cccaggatgg cgaaggctgg gcgggatgct ttaccgagga cggtgccttc gagttcgacg
3889501 gctgggtgat ccgggggcgg cccgcattac gcgaatacgc agatgcgcat gcccgcgtcg
3889561 tgcggggccg ccacttgacc acggatcttc tctacgaggt cgacggggac gtcgccaccg
3889621 ggcgcagcgc cagcgtggtc actctggcca ctgccgccgg ctacaagatc ctcggctcgg
3889681 gcgagtacca ggatcgcctc atcaagcagg acggccagtg gcgtatcgcg taccggcgat
3889741 tgcgcaacga tcggctggtg tcggatccca gcgtggcggt aaacgtcgcc gatgccgacg
3889801 tcgccgcggt cgtcggtcac cttctcgcgg ccgcgcgccg gctcggaacc cagatgagcg
3889861 acacgtaggg gcgacaagct agggccgacg tcggtgtacg gacacacgcg ctcgcgggtt
3889921 ggctgtgcag gaccttccct aaccccatca tcggacgccg acatgccgag cgagaaaatc
3889981 taggaccgcc cctgcgaaag cgtcgttgcg atcgccggcg accatatgtc cggcgccgcg
3890041 cacatcggtg aactcgactt gcggaaaccg cgagagaaat tggtcggcgc tttcttggcg
3890101 gacgatgtcg ctgacttggc cgcgcacgag aagcaccggc acttcgtcgc gcaggatcgt
3890161 cgcaacggct gcattcatgc ggtcgacgtc ggtgacctct acgggaggaa acgccgcgat
3890221 accaccgatg aactgcggat cccagtgcca ataccagcga tcaccgcggc ggcgcaggtt
3890281 ggccaccaag ccatccggat ccgaaggccg cggccgatgc gggttgtagt tggcgatgac
3890341 gtcagccacc tcgtccaacg agccgaaccc cgattccacc cgttcggcca tgaacgcgtg
3890401 gatcctgctc gccccggcca ggtccatatt cggcacgatg tccaccagca ccactgcgct
3890461 ggcaatgccc ggcgagagct cccccgccag cagcatcgcg gcaaacccac ccaaggaggc
3890521 gcccaccagc gccggctgcc caggcaggtt gcgcagcact tcctggatat cgccggcgaa
3890581 gctgaccaac cgatagtcgc cttcgctcga ccagtcggat tcgccatgcc cgcgcagatc
3890641 gatcgtgacc gcttgccagc cacgttcggc gacagcggct gcggcccgac cccatgagcg
3890701 tcgcgtctgt ccaccgccat gcaagaacac cacggcacgc gctcgcgggt ctcccaagcg
3890761 gtcggcgacg atacggactg aaccgccccg gcatgtccgg agactccagt tcttggaaag
3890821 gatggggtca tgtcaggtgg ttcatcgagg aggtacccgc cggagctgcg tgagcgggcg
3890881 gtgcggatgg tcgcagagat ccgcggtcag cacgattcgg agtgggcagc gatcagtgag
3890941 gtcgcccgtc tacttggtgt tggctgcgcg gagacggtgc gtaagtgggt gcgccaggcg
3891001 caggtcgatg ccggcgcacg gcccgggacc acgaccgaag aatccgctga gctgaagcgc
3891061 ttgcggcggg acaacgccga attgcgaagg gcgaacgcga ttttaaagac cgcgtcggct
3891121 ttcttcgcgg ccgagctcga ccggccagca cgctaattac ccggttcatc gccgatcatc
3891181 agggccaccg cgagggcccc gatggtttgc ggtggggtgt cgagtcgatc tgcacacagc
3891241 tgaccgagct gggtgtgccg atcgccccat cgacctacta cgaccacatc aaccgggagc
3891301 ccagccgccg cgagctgcgc gatggcgaac tcaaggagca catcagccgc gtccacgccg
3891361 ccaactacgg tgtttacggt gcccgcaaag tgtggctaac cctgaaccgt gagggcatcg
3891421 aggtggccag atgcaccgtc gaacggctga tgaccaaact cggcctgtcc gggaccaccc
3891481 gcggcaaagc ccgcaggacc acgatcgctg atccggccac agcccgtccc gccgatctcg
3891541 tccagcgccg cttcggacca ccagcaccta accggctgtg ggtagcagac ctcacctatg
3891601 tgtcgacctg ggcagggttc gcctacgtgg cctttgtcac cgacgcctac gctcgcagga
3891661 tcctgggctg gcgggtcgct tccacgatgg ccacctccat ggtcctcgac gcgatcgagc
3891721 aagccatctg gacccgccaa caagaaggcg tactcgacct gaaagacgtt atccaccata
3891781 cggatagggg atctcagtac acatcgatcc ggttcagcga gcggctcgcc gaggcaggca
3891841 tccaaccgtc ggtcggagcg gtcggaagct cctatgacaa tgcactagcc gagacgatca
3891901 acggcctata caagaccgag ctgatcaaac ccggcaagcc ctggcggtcc atcgaggatg
3891961 tcgagttggc caccgcgcgc tgggtcgact ggttcaacca tcgccgcctc taccagtact
3892021 gcggcgacgt cccgccggtc gaactcgagg ctgcctacta cgctcaacgc cagagaccag
3892081 ccgccggctg aggtctcaga tcagagagtc tccggactca ccggggcggt tcagacaccg
3892141 cccggcccgt ggaccgagaa cgattcagct gccattgata tcgggtccat caggggatcc
3892201 agaaccatcc gtttgcatgc cctaccacga tcctgtccta ccgagcggcc cgcagtcacc
3892261 ccagattcgg cgtcaatccg gcacccggtt cgtggtccat ccacggaacc caaggcgcca
3892321 ttttcgcagt gattgcacgc tcggcgaaag gtgttaccca gacgctacag ctatgcgtgc
3892381 ccgtagaatg caaatccctg ctcgcggtcg aggtaggtat cggccttgtt cttgatgaaa
3892441 aacacataga caatcagcga gaccgctatg cacgcggtca cgtaggcgat gaacatcggc
3892501 acctgatcgc gttccttaag agcctggtag atcagcggcg cggtgccgcc gaagaccgag
3892561 ttcgccagtg catagccgac tccgacacca agggcgcgca cgtgcgcggg gaacagttcg
3892621 gacttgacca gtgcattgat cgagcagtat ccggtcagaa tcacatagcc aacggccacc
3892681 aatagaaacg acattgtcgg cgaacgtgtt tcgggaagat aagtaacaag gacgtaggta
3892741 tagatgagtc cgccgacgcc gaaccacagc agcagtggct tgcggccgat cttgtcgctg
3892801 atcatgcccc cgatgggctg cagcatcatc aacagaatca gaccaaccag gttgatccaa
3892861 gtagcggtca tcgcctgcga accgtagaca ctcttgacga tcgcaggtgc attgacgctg
3892921 taggtataaa acgcgaccgt gccgcccaac gtgacgagga aacagagcag caatggcttc
3892981 caatagtggg tggccagttc acggagcgac ccggagtcgt ggtcccgccc ggccttgatc
3893041 gcagtcaggc gttcctgact gagcgattca tccatcgtgc gccgcaacca gaacaccacg
3893101 atcgcggcgc caccgcctac ggcgaagccg atgcgccagc cgaattcgtg aacctgctcg
3893161 cgggtgaaga ccgccaggat gactagcagg gtgaactggg caagcacgtg cccacccacc
3893221 agcgtcacat actgaaacga cgagaagtag ccgcgccgct cccgcgtcgc ggcctcagac
3893281 atgtacgtcg ccgacgtgcc gtactctccg ccggtcgcaa atccctggac gagccgacac
3893341 aaaataagca ggatcggcgc agcgacgcca atgctcgagc gagacggcac caacgccacg
3893401 atcagcgaac aggcggccat cagcgacaca ctgaacgtca gcgcggcccg gcggccgcgg
3893461 cggtcggcaa accgaccaag gaaccacgat ccgacgggcc gggtcacgaa ggtaacagcg
3893521 aagatcgcgt agacatagac cgtcgagttg cgatcggccc gatcaaagaa ttggtcctcg
3893581 aaatacgtag cgaacacggt gtagacgtag acgtcatacc actcgaccag attgcccgac
3893641 gatccccgga tcgtgttcca aatggcccga cgggtctcgg cctgactcgg gcgcgatgga
3893701 ggtgcaatgg aaacggtcat ggtgtcctcc atgcgattcg cattgtcgcg ccgtctgacg
3893761 gtcaccatag tgaccgacgt cagcacccgc cgtgcagggc tggagcgtgg tcggttttga
3893821 ctctgcggtc aaggtgacgt ccctcggcgt gtcgccggcg tggatgcaga ctcgatgccg
3893881 ctctttagtg caactaattt cgttgaagtg cctgcgaggt ataggacttc acgattggtt
3893941 aatgtagcgt tcaccccgtg ttggggtcga tttggccgga ccagtcgtca ccaacgcttg
3894001 gcgtgcgcgc caggcgggcg atcagatcgc ttgactacca atcaatcttg agctcccggg
3894061 ccgatgctcg ggctaaatga ggaggagcac gcgtgtcttt cactgcgcaa ccggagatgt
3894121 tggcggccgc ggctggcgaa cttcgttccc tgggggcaac gctgaaggct agcaatgccg
3894181 ccgcagccgt gccgacgact ggggtggtgc ccccggctgc cgacgaggtg tcgctgctgc
3894241 ttgccacaca attccgtacg catgcggcga cgtatcagac ggccagcgcc aaggccgcgg
3894301 tgatccatga gcagtttgtg accacgctgg ccaccagcgc tagttcatat gcggacaccg
3894361 aggccgccaa cgctgtggtc accggctagc tgacctgacg gtattcgagc ggaaggatta
3894421 tcgaagtggt ggatttcggg gcgttaccac cggagatcaa ctccgcgagg atgtacgccg
3894481 gcccgggttc ggcctcgctg gtggccgccg cgaagatgtg ggacagcgtg gcgagtgacc
3894541 tgttttcggc cgcgtcggcg tttcagtcgg tggtctgggg tctgacggtg gggtcgtgga
3894601 taggttcgtc ggcgggtctg atggcggcgg cggcctcgcc gtatgtggcg tggatgagcg
3894661 tcaccgcggg gcaggcccag ctgaccgccg cccaggtccg ggttgctgcg gcggcctacg
3894721 agacagcgta taggctgacg gtgcccccgc cggtgatcgc cgagaaccgt accgaactga
3894781 tgacgctgac cgcgaccaac ctcttggggc aaaacacgcc ggcgatcgag gccaatcagg
3894841 ccgcatacag ccagatgtgg ggccaagacg cggaggcgat gtatggctac gccgccacgg
3894901 cggcgacggc gaccgaggcg ttgctgccgt tcgaggacgc cccactgatc accaaccccg
3894961 gcgggctcct tgagcaggcc gtcgcggtcg aggaggccat cgacaccgcc gcggcgaacc
3895021 agttgatgaa caatgtgccc caagcgctgc aacagctggc ccagccagcg cagggcgtcg
3895081 taccttcttc caagctgggt gggctgtgga cggcggtctc gccgcatctg tcgccgctca
3895141 gcaacgtcag ttcgatagcc aacaaccaca tgtcgatgat gggcacgggt gtgtcgatga
3895201 ccaacacctt gcactcgatg ttgaagggct tagctccggc ggcggctcag gccgtggaaa
3895261 ccgcggcgga aaacggggtc tgggcgatga gctcgctggg cagccagctg ggttcgtcgc
3895321 tgggttcttc gggtctgggc gctggggtgg ccgccaactt gggtcgggcg gcctcggtcg
3895381 gttcgttgtc ggtgccgcca gcatgggccg cggccaacca ggcggtcacc ccggcggcgc
3895441 gggcgctgcc gctgaccagc ctgaccagcg ccgcccaaac cgcccccgga cacatgctgg
3895501 gcgggctacc gctggggcac tcggtcaacg ccggcagcgg tatcaacaat gcgctgcggg
3895561 tgccggcacg ggcctacgcg ataccccgca caccggccgc cggatagcac gaccggtttg
3895621 cgcggatgcg tcggcgttgt tccccgccgc ggttggcgtg ctctggcaat ctggtctaag
3895681 ggacccgacc ccaccgggcg gaccccacgg catcgagggg ctgtcgctgg cattcgaaaa
3895741 gccgtcaccg gtaacggcat tgacgcagga actacgattc gcgacgacca tgacgggcgg
3895801 cgtcagcctc gcgatctgga tggccggtgt tacgcgggag atcaacctgc tcgcgcaggc
3895861 ctcacaatgg cgcaggctgg ggggaacctt cccgaccaac agccaactca ccaacgagtc
3895921 agccgcttcc ctgcggctct acgctcaact aatcgacctc ctcgacatgg tcgtcgacgt
3895981 cgacatcttg tcgggaacaa gtgcgggcgg catcaacgcg gctttgcttg cgtcatcccg
3896041 agtcaccggg tctgacctgg gcgggatccg cgacctctgg ctcgatcttg gggccttgac
3896101 cgagcttctc cgagatccgc gggacaagaa aacaccgtcc ctcttgtacg gcgacgaacg
3896161 catattcgcc gctctggcca agcggcttcc caagctggcg accgggccgt tcccgcccac
3896221 gacctttccg gaggccgcgc gcaccccgtc caccaccctg tacatcacga cgacgctgct
3896281 agccggggaa acaagcagat tcaccgactc attcggcact ctcgtccagg atgtcgacct
3896341 ccgcggtctg ttcaccttca ccgaaaccga cctggcgcgg ccagacacgg cgccggcgct
3896401 ggcactagca gcgcgcagtt ccgcctcatt cccacttgcg ttcgaaccct cctttctgcc
3896461 gttcacgaag ggaaccgcca agaagggaga ggtgccggct cgaccggcga tggcgccgtt
3896521 caccagcctt acccgtccgc actgggttag cgatggtggc ttgctggaca accggccaat
3896581 tggcgttttg ttcaagcgca tcttcgaccg tccagcccga cggccggttc gccgggtgct
3896641 cctgttcgtc gtaccatcgt ccggacccgc acccgacccg atgcatgagc caccaccgga
3896701 caacgtcgac gagccactcg ggctcatcga cgggctgctg aagggcctgg ccgcggtcac
3896761 cacccagtcg atcgcggccg acctacgcgc gatccgcgcc catcaggact gcatggaagc
3896821 gcgcacagat gccaaactgc ggctcgcaga gctggcggca acgctgcgga acggcacacg
3896881 gttgctcacc ccgtccctgc tcacggatta ccggacccgc gaggcaacca agcaggccca
3896941 gaccctcacc agcgctctgc tgcgccggct ttccacctgt ccgccggagt cgggcccggc
3897001 aaccgaaagc cttcccaaga gctggtcagc cgaactcacc gtcggtggtg acgccgacaa
3897061 ggtgtgccgg cagcagatca ccgcgacgat cctgctttct tggtcgcagc cgaccgccca
3897121 gccgctccca cagagtccag ccgagctggc tcggttcggt cagccggcct acgaccttgc
3897181 aaaaggatgc gcgctcaccg tcatccgggc ggcattccag ctggcacgtt cggatgctga
3897241 catcgccgcg ttggcggaag tcaccgaagc aatccaccgg gcgtggcgac cgaccgcgtc
3897301 atccgatctc agtgtgctag tgcggacgat gtgtagcaga ccagcgatcc gacaagggtc
3897361 gctcgagaac gccgctgacc agctcgctgc cgactatctc caacaatcca cggtgcccgg
3897421 cgacgcttgg gagcggctcg gtgccgcctt ggtgaacgcc tacccgacct tgacgcaact
3897481 tgccgccagc gcttcagccg actcgggtgc cccgacagac tctctgctcg cccgggacca
3897541 tgttgcagcc ggtcagttgg aaacgtacct cagctatctg gggacctatc cagggcgtgc
3897601 cgacgactcg cgcgacgcac cgaccatggc atggaagcta ttcgatctcg ccacgacgca
3897661 gcgcgcgatg ctcccggccg acgcagagat cgagcaaggc ctcgaactcg tgcaggttag
3897721 cgccgacacc cgcagcctgc tcgcacctga ctggcagaca gcccagcaga agctcaccgg
3897781 catgcgcttg catcatttcg gtgcgttcta caagaggtca tggcgagcca atgactggat
3897841 gtggggccga ctcgacggag cgggatggct cgtccacgtg ctgctagacc cgcgccgggt
3897901 gcgctggatc gtcggggagc gcgccgatac caacgggccg cagagcggtg cacaatggtt
3897961 cctaggcaaa ctcaaagaac ttggggcacc tgactttccg agtccgggct acccgctgcc
3898021 ggcggtcggc ggcgggccgg cccaacatct gaccgaggac atgctgctcg atgagcttgg
3898081 cttcctggac gacccagcaa agccgctgcc ggccagcatt ccgtggaccg cgctgtggtt
3898141 gtcgcaggcg tggcaacaac gagtcctcga agaggaattg gacggactgg ccaacacggt
3898201 gctcgaccca cagcccggaa aattgccgga ctggagcccg acgagttcac gaacatgggc
3898261 gaccaaggta ttggccgctc accctggcga cgccaaatat gctctgctga acgaaaatcc
3898321 aatcgcaggc gaaacattcg ccagcgacaa gggctcacca ctgatggcgc acacggtcgc
3898381 caaagccgcc gcgactgcgg ccggagcagc cggctcggtc cggcagctgc ccagtgtatt
3898441 gaagccacca ctgatcacgt tgcggacact caccctcagt ggataccgag tggtctcgtt
3898501 gaccaaaggc attgccagat cgaccattat cgccggcgcg ctgctacttg tgctcggcgt
3898561 cgcggcggcg atccagtcgg tgaccgtgtt cggagtcact ggcctgatcg cggccgggac
3898621 tgggggcttg ctggtcgtcc taggcacttg gcaggtctcc ggcaggctcc tttttgcact
3898681 gctgtctttc tcggttgtcg gcgcggtact cgcgttggcg acgcccgtcg tacgcgaatg
3898741 gctgttcggc acccagcagc agcccggctg ggtaggcact cacgcgtatt ggcttggcgc
3898801 ccaatggtgg caccccctgg tcgtcgtcgg gctcatcgca ctggtggcca tcatgatcgc
3898861 agcggccacc ccaggacgac ggtgacgatg cgtgcggtga tccggaattc aggaaccgag
3898921 gcccgcggcg ccgtcagccg ccgccaactg atcgagcgct tcgccggtgt agacggcgag
3898981 ccgctgcagg tgtggcagtg tgtcacggca gccgatgaat ccaaagttca gcgtgccggc
3899041 gtaactctgc aaagtaacgt tgagagcctg gctgtgcgcc accagggaga ccggatagga
3899101 cgcctccatc cggctgcccc gcaggtagag cacgtcctcg ggccccggca cattgctgac
3899161 acacaggttg aacgtgtacg gccagggtgg cttcacccca ctgagcgtgc tggccaactg
3899221 caccccgtac ggcgccatca acgcggcgct ataggccagg atcgcgtcct tgtccatgga
3899281 cctcagctga gccttggccg cgcgggttga cgccgtgacc gccgccagcc gctgcaccgg
3899341 atcggcaacg tcggtaccca acgtcgccag gatggtcgcg accgcgttgc cgccgccctc
3899401 gtcgtccttg ggtcgcacgt tgaccggcaa gaccacgatc agcgacttgt tgggcagctc
3899461 acccagctcg tccagaaaac gtcgtaagcc gcctccgatg atcgccaacg cgacgtcgtt
3899521 gattgtggca tcatattgag ccccaatggc tttcagtcga tccagcggat attgctgggt
3899581 ggcgaagcgg cggttgcggc tgatgcgggt gttgagtatg cagtgcggcg cttgcaccga
3899641 gccgacgagg ttgcggtact cgtgatcact gcgcagctgg gcgttgacca gcgccttggt
3899701 gagctcgaac gtcgatcgtc ccgcaccggc caccgaacct aagacgctac cgaccccgct
3899761 gaccagcccg cccaaccccc gcaccacgtc gcccaggcca tcgagcacgt taccggcccc
3899821 agctatcaaa ccgccgccga cggagtcttg agtgtcggcg ggtgatcggc caggtgtggg
3899881 aatgttgaag aacaacgggt gggtggtgtc gtgcgggtcg gtggacaggc tgcgggccag
3899941 cattttctgg ccggtatagc cgtctatcaa cgagtggtgc atcttgatgt agatcgcgaa
3900001 ccggccacct tcgaggcctt cgatgaaatg cacttcccac ggcggacggc gtaggtccag
3900061 ggcgtgacta tgcaagcggg acaccgggat cccgagttca cgctcgtcgc cagggctggc
3900121 cagcgccgac cggcgcacgt ggtagtccag gtcgaagttg tcatcaacga cccaggactg
3900181 cgtgggatgg tatagcagct ccggatggct cagtcttagg ctccagggtt cgacgacctc
3900241 gctggccttg ctttcgtcga cgagttggcg cagcaagtcc ggcggcgcac ccgagggcgg
3900301 cgtgaacggc atcaacgcac caacgtgcat catcgtggtc gacgattcgg agtacaggaa
3900361 aaacatgtcc tgcggaccca accgccgggc cgtctggctc acgggccact ccttcgttgg
3900421 aggcattctc aggccgtcta gcgccgccag ataactaccg tagatgatcg cggccgtgcg
3900481 ttgtacgccg catcacatcg cgtgaactcc gttgtagagc agcagtaaac cgatcacgac
3900541 cagaatggcc gcgaccatcc cggcatggtt cttctccatc cagtctttaa gtcgttccag
3900601 cgaatcgtcg agtcggtcac cggcagccac gtaggccaat atcgggatcg cgaccgtgga
3900661 tgcagccaac atggcaaaga atgccgtgta aatccaggaa cccgcggcgc cgtggccgcc
3900721 gctgccgatg gccaatccgg ccgccgcgca aatgatcagc acctcgggtc tcaccaccac
3900781 cagcacggcc cctaccaatc cggcgcgtgc cggggtgaag ctggcgaatg cgcgcatcca
3900841 gcccggcatt tcggtgtggc gatgccgggt cagccaccga agcacgccga acacgatcag
3900901 tgccgacccg aggaccaccc gtagccagga tgcccaggcc ggcgatgttg tgctcaaacc
3900961 gccaagtgcg ccggaggccg caacaaagac ggcggtcacc acggccaagc ccaacagcca
3901021 gccgcccagg aaggccaggc tgctcggccg cggctgcggc gagtgtacga ccagtaccgc
3901081 tgggatcacc gacaacggcg agagcgcaat gaccaacgcc agcggcacga gcccggtgag
3901141 cacggagacc caatgacctg ccacgggcag caatcctcgc attgacaccg cctcggtgac
3901201 caccgagcgc cccaattcga cgaaattgcg cgcacccaac cgccgttcgg gctgttgata
3901261 gccatcgcga gacgtcgatc gccgaaacgt acgtgcaaag acggcggctt ggtgagccga
3901321 cgattaacga cgctgcccgg ccaaacgctc gccctgacag aattgcgacc cgaagtccac
3901381 cgtcacggtc gacggcgtgc ggaactgagc ggcgaaggtg agctggggat ccaccggcgc
3901441 ctgatcgagc cccagtcgct ttgtctcgag gttgatctcc acggtatcgg gggcagttct
3901501 gcgcgcattg gtgttccggt ccggccgcat gttcggctcg gtgcctctgc tttcgccggg
3901561 ctttctgatg gcaagttcat cggtgtcctg ctgcgggccc agctcggcga actccttgcc
3901621 attgttggcg atggtgtagg tcagcaggta accggcaaag cccgacgcaa acgagcccga
3901681 tggcgacggt ggcagcggct cggcgaatcg aactaccagc cgaaggaccg cgcctcgggg
3901741 atgcgagacg tccacggagg ccacggtaat ggtcgcgggc ggtgtcggcc cgggccgcaa
3901801 ctggcaactg agtcgcttcg gcagctgcga ccagtcgtct ggcagcggcc tgatccaggc
3901861 gtagaccgcg acacctacca tcgtcagcac tgccgcgacc ggaactgtca accgcaggcc
3901921 ggccggcatg cccagccagc ggctccggag accgtcgaca cgcagggcca gcggtgatcg
3901981 tggtgcagag gggttgggtc gacgatgtct ggtccagcgg tcaccgtccc aatatcgttg
3902041 ccccgctgaa ccgtcaggat cggtatacca tcctgccggc ggcgaagtcg ccacgtcgtg
3902101 ctccattcaa cagtcggtaa ggatcagctg cggtgccgct cctcgcggac tacggcggcg
3902161 catcgaacaa ctccggtagc gaatcgagga tctgcacgtg gtcgccgcgc cacgcaaacc
3902221 ccacaatcgt caagatgcca tcttggcagc cgtcacagct ttgacgtgtc cgatagctca
3902281 gcaccacgat gtcgtttgtg gatgccggac cgatcaaatt ggtgaacggg taggccctcg
3902341 gcgttgcggt tccgacgaac gttccccgat gaaacatcag cgcctggtcc ggggagctgt
3902401 tggtggcgtc ttgcaccgtc accagcaccg cggacaggtc cgcgcacggg tcgtagttgc
3902461 tgtcctccgg cgtactattc cacggcctgc cggttttgga atcgggggca agctgggcca
3902521 gcgcggcgcg cacggccgtt gcctcgtccg gcccacacgg gccaacctgg gatgccgggg
3902581 aagtggggcg cgccggtgcg gacgtcgttg ccggcgccgc ctggttggca cctggtcgga
3902641 cccgatgcat accggcgtac gcaacgaccg cggcagccac acaggccagg accacgagcg
3902701 ccaccagcca ggcggtgggc caagacccgc ctggggcggg cggagtggta tcgacgtcat
3902761 cggacggctg gtatgccggc gcaggccagt cggggtcaat ctcgtcagac acctaacccg
3902821 ctaaccctcc cggtacccgc ccgctggctg tgcgatactt gccgagcttg ccgaattgta
3902881 gccagaacgt gcaggtagcg gaaacaagcg ggccgtctcg aggggccccg ccggccggtg
3902941 aggctgacca catccagcat tctgatagct ggcttcacag caatctggcc ccatactaga
3903001 cgtcatgcag caagcgacgg caccgcaacc gctggcagcg cgccagttgg ttcgacggcg
3903061 cctggccgag gcatatgatg gcgcgttctg agggcaatcg cccacgccat cgcgctgtgc
3903121 ctcagccgtc gcggatccgc aagcggctgt cgcggggcgt tatgacgctc gtgtcggtgg
3903181 ttgccctgct gatgaccggc gcagggtatt gggtagccca cggcgcgctg ggcggcatca
3903241 ccatttcgca ggccctaacc cccgaggatc cccgttccag cggcaacaac atgaacatct
3903301 tgctcatcgg gctggactcg cgcaaagacc aggaaggcaa cgacctgccc tggtcggtct
3903361 tgaagcagct acacgcgggc gattccgacg acggcggcta caacacgaac acgctgatac
3903421 ttgtgcacgt cggtgccgat ggcaaagtgg tggccttctc gatcccccgc gacgactggg
3903481 tgcccttcac cggcgttccg ggatacaacc acatcaagat caaagaggcg tacgggctga
3903541 ccaagcaata cgtggcagaa cagctggcca accagggtgt gagcgaccgg aaagagctcg
3903601 agacccgggg ccgtgaagct gcccgggccg cgaccctgcg ggcggtgcga agcctgaccg
3903661 gcgtcccgat cgactacttc gccgagatca atttggccgg tttctacgat ttggcccaga
3903721 ccctcggcgg cgttgatgtg tgcctgaacc atgccgtcta cgactcgtac tccggagccg
3903781 acttccccgc cgggcgtcaa cggttgaatg ccgcgcaggc gctggcgttt gtccggcagc
3903841 gtcatggcct agacaacggg gacctggacc gcacccaccg ccagcaagca ttcctgtcgt
3903901 cggtcatgcg cgaacttcag gattcgggca ccttcaccaa cctggacagg ctcgacaacc
3903961 tgatggccgt ggcacgcaaa gatgtggtgc tgtcggccgg ctgggacgag gacctgttcc
3904021 gccggatggg cgacctggcg ggcggtaacg tcgaattccg gacgctgccc gtggtgcgct
3904081 acgacaacat cgacggccag gatgtcaaca ttatcgaccc gaccgcgatc cgggccgagg
3904141 tagcggcggc atttggcagc gcgccgccaa cgtcgcagac cgccgcggcc gccaaaccta
3904201 acccatccac cgtcgtcgat gtggtcaatg ccggcagcat cagcggactg gccagccagg
3904261 tctccggtgc gctgctgaag cgcggctaca ccgcgggtca ggtgcgtgac cgcgaatccg
3904321 gcgatccgtt caccaccgcc atcgagtacg gtgccggcgc ggaaacggac gcccagaacg
3904381 tggcagacct gctcggtatc gacgccccca accatcccga tcccgccgtc gcgcccggac
3904441 acatccgtgt gacggtggat accaacttct ccctaccggc acccgacgag gccaccgccg
3904501 ccgcgacgtc caccgaaacc agcacatatc cgctgtacgg cggcggcacc accaccgacc
3904561 cgacaccgga ccaaggggcg cccatcgatg gcggcggcgt gccctgcgtg aactaggtaa
3904621 gttatccgac cactccacgc agcccgtcgg cgccgaacac cggctccagc atgggcgaga
3904681 agtccgggcc ccttcgcagc atgtggccgc cgtcgacgtt gatgacctgt ccggtgatcc
3904741 aactggccgc gtcgctgagc aaaaacattg ctaggttcgc gacgtcttcg acctcaccca
3904801 cccgcggtaa tggcgtgcag acccggtagt ccgcgctcag ctccggcgac tctgtgacgg
3904861 gcacaaccag atctgtacgg atcaggcccg ggcggatgct gttgacccgt acccacgacg
3904921 ggccgagttc gtcagcggcc agtttcatca tgtggtcaac ggccgacttg gtgaccccgt
3904981 aggcgccgaa ccagcgatgg gtgttgctgg ccgcgatcga ggagatgccg acgaacgaac
3905041 cgccgccgcc gcgtaccaat tcccgcgcgg cgtgcttgag cacgtacatg gtgccattga
3905101 cattgaggtc cacggtgcgc cgccaggcct gcgagtcgat ctgggtgatt ggcccaatgg
3905161 tctgagaccc gcccgcgcaa tgcaccacac cgtgcagccg gccatgccac gcggttgccg
3905221 cgtccaccac acgcagggtc tgctcctcgt cggtgatgtc ggccggctca tagccgatcg
3905281 ctccggtctt gagcgcctcg atgtctttga cagccgccgc cagcttgtct ggatttcgtc
3905341 ccacgatcat gacggcggct ccagccgcga ccaacccggc ggccaccccc ttgccgattc
3905401 cgctgccacc tccggtgacc aggtaggtcc ggtcttggaa agaaagctgc acttgaggcc
3905461 cctcacgccg aaactgaaac aggttctcgc cattttggac catgcggccc gtcacttgcg
3905521 ccgaaggtga actcacggcg aggtttcgcg gcgctcgcga attcatgccc tcagttcacg
3905581 ttcgacgttc gtgatcaacg gtgccgccat cgtggaggga ttccataggt tgcggcttgt
3905641 tgccacattg cggccagtgt gcgccgccgg gtgcgcgtcc acggtaggct tcaaccacga
3905701 attatcgggc aacgatatcg gagtcggagt tggcaataac tggttcggcc gcaccgtcat
3905761 ggccgcgact attgcacgcc gagggccccc cttccgtcat ttgtatacgg ctgttggtgg
3905821 ggttggtgtt tctcagtgag ggaatccaga aattcatgta tccagatcag ctgggtccgg
3905881 gccgcttcga gcggatcggc atccccgccg ccacgttctt cgccgatctg gacggggtgg
3905941 tcgagattgt ctgcggcaca ctggtcctcc tcggcctgct gacccgggtc gcggcggtgc
3906001 cgttgctcat cgacatggtg ggagcgatcg tgctgaccaa actccgagca ctgcagccgg
3906061 gcgggtttct cggggtagag ggcttctggg gcatggccca cgctgcccgg accgacctgt
3906121 cgatgctgct cggattgatc ttcctgctgt ggtccggccc cggccggtgg tcactagata
3906181 ggcgactgtc caaacgcgcc acggcttgcg gcgcgaggtg aacccgcgac gtagcgcgac
3906241 cgatgcaccg gactcaacga cgagtcagcg gtggcgtcgc gaatgaactg cccgatctga
3906301 cgcaacgaac gggtcgcttc gggcaccagc ggtgtggcga gttggaaaag atgagcctga
3906361 ccgggccaaa cccgtacctc ggcacagacg cctgccgccg ccagcttgcc ggcgcccagc
3906421 tgcgcgtcgt gcagcagcac ttcggagccg gaaacgtgaa taagtgtcgg cggcaagctg
3906481 gattcgatat ggtcgagcgg ctcatagagg tcttcgggcc tgccgtcgac catgttcttg
3906541 gcagcggccg ccctgaccca tgccgccaag gcatcgaatg cccgcgccgg aaacatcgcg
3906601 tcggtcccga tgttgggatg gtcctgcttg ggccccttgg ccagctgcag caacggagag
3906661 atggccacta ttgccgccgg tttctcgtcg tcgcactgca gccgctgcgc aagcgcgagc
3906721 gcaaggtaac cacccgcgga atcaccggcc aacacgatct gttccggccg gtatccgcgc
3906781 gcccgcaacc attggtatgc atcgtggcag tcgtcgagcg ccatccccag cgaatgctta
3906841 gggatcagcc gatagtcgac tatcaacacg ggtgattcgg caaatcctga cagcgcgttg
3906901 acgatcctgc tgtgcgaatt cggcccgcac atgacaaacg cgccgccgtg caaatagagc
3906961 accacccgcc cagcgccgtc ggccgcccgc accccaggcg cacgcaccaa ctgggcggta
3907021 gcattcggca aatttatcgt tgttcggacc gtgccctgcc cggggcgcca aaccctgcat
3907081 gcgaagtcga cgaaccccaa cggcagaggc aggggcgata ggtaactgcc cacagtcata
3907141 agtggcttga tcgtcatgcg cgatgccagt gccgccaacc gacctgcaac actagggccg
3907201 ctttcggtga tctcgatggg agccccgtcc cagcacgaat cggaattcga gcatcccgac
3907261 gattgcaggg gccggcgtgc gtaatacgag gacattttca gcacgtttcg ccggaatgtg
3907321 gccggtggtt ggcgttagct gcacggaagc gcctgagctg gcccgccgtc accgcccgat
3907381 ttatcaatcg caaatctcgc acttcccgtt tacgtagttg ctccaaccag acgcagccca
3907441 attcgggctc ctccccccat caatcattcg gtggcgcgaa gttcaccaga gtcccggaca
3907501 cgctcacgcg aactacctgc atttagggga tcacaggcac cttgaaatgc atcggtgtat
3907561 gactgggagt ttgctgtacg tctattggta agtgcgaatt cgccgccggc tacccgcacc
3907621 ccgtagaatc gcaagccgat atcggcttgg tcacctgagg tgttctatgc gggagtttca
3907681 gcgggccgcg gtgcgcctgc acatcctgca ccacgctgcc gacaacgagg tgcacggcgc
3907741 gtggctgacc caagaactga gccggcacgg ctaccgggtc agccccggca cgttgtaccc
3907801 gaccctgcac cggctcgaag ccgacggcct gctggtgtcc gagcaacggg tcgtcgacgg
3907861 ccgcgcgcgc cgcgtctacc gggctacccc ggctggccgg gcagcactga ccgaggatcg
3907921 ccgggcactg gaagagctgg cccgcgaagt cctcggcggg caatcgcaca ccgctggtaa
3907981 cgggacctga accgcgtcga cggtacccat cgccggggcc aaaccgtgac gacgtctgca
3908041 gcgcaatgcg ggcttggctt acagttatgt aatgtctacc aaatctgacc acggcgaaat
3908101 cggtgacgtc gaaccgctgg cagacagcac cgcgagccag gccaggcgag tcgtcgccgc
3908161 atatgcgaac gacgccgacg agtgtcggat cttcctgtcc atgctcggta ttggaccggc
3908221 caaactcgag agctaatggc tccctcggga ggccaggagg cgcagatttg cgattcggag
3908281 accttcgggg actctgactt cgtggtggta gccaatcgac tgcccgtcga tctggagcgt
3908341 cttcccgacg gcagcacaac ctggaaacgc agccccggag gcttggtcac cgccttggag
3908401 ccggtgctgc ggcgtcggcg cggggcctgg gtcggctggc ccggcgttaa cgacgacggg
3908461 gccgaacccg acctccacgt gctggacggc cccatcatcc aagacgagct ggaacttcat
3908521 ccggtacggc tgagcaccac ggacatagct cagtactacg agggattctc caacgccaca
3908581 ctgtggccgc tgtaccacga cgtcatcgtc aagccgctct accaccgcga atggtgggat
3908641 cgctacgtcg acgtcaacca gcgctttgcc gaggccgcgt cgcgcgccgc cgcccacggc
3908701 gcaaccgtgt gggtacagga ctaccagctg cagctggtac cgaagatgct gcgcatgctg
3908761 cggcccgatc tgaccatcgg tttctttttg cacatcccgt tcccgccggt agagctgttt
3908821 atgcagatgc cgtggcgcac cgagatcatc cagggcctac tgggcgccga cctggtgggc
3908881 ttccatcttc cgggcggtgc ccagaatttc ctgatcctgt cccggcgtct ggtcggcacc
3908941 gacacttccc gcggaaccgt cggtgtgcgg tcgcggttcg gtgcggcggt gctcgggtcc
3909001 cgcaccatac gagttggcgc ctttcctatc tcggttgact ccggcgcgct cgaccacgct
3909061 gcccgcgacc gcaacatcag gcgccgggcc cgcgagattc gcaccgaact gggaaatccg
3909121 cgcaagatcc tgctcggtgt tgaccggctc gactacacca agggcatcga cgtacggctg
3909181 aaggcctttt ccgagctgct ggccgagggc cgcgtcaaac gcgacgacac cgtcgtggtc
3909241 cagctggcta ccccgagccg cgagcgggtg gagagctacc agacgctgcg caacgacatc
3909301 gaacgccagg tcggccacat taacggcgag tacggtgagg ttggccatcc ggtagtgcat
3909361 tacctgcatc gaccggctcc gcgcgacgag cttatcgctt tcttcgtggc cagcgacgtc
3909421 atgctggtca ccccactacg cgacgggatg aacctggtgg ccaaggagta cgtcgcttgc
3909481 cgcagcgatc ttggcggtgc cctggtgctc agcgaattca ccggggccgc agccgaactc
3909541 cggcacgcat acctggtcaa cccgcacgac ctggaaggcg tcaaggacgg gatagaggaa
3909601 gcgctcaacc agacggagga ggcgggccgg cggcgaatgc ggtcgctgcg acgccaagtg
3909661 ctcgcccacg acgtggaccg ctgggcacag tcgtttctcg acgctctcgc cggggcacac
3909721 ccgaggggcc aaggctaacg gtcaagccgc tcccgctcgc gagcagacgc agaatcgccc
3909781 atttcggcac gaaattgggc gattctgcgt ctgctcgcgc cctggaagct ggtgcggctg
3909841 cccaaaggct gtgatactcg atggagcgcg aaggcccgaa ggagggcatg tgaacatccg
3909901 ttgcggactg gccgctgggg ccgtcatctg ctcggccgtc gcactgggaa ttgcgctgca
3909961 ctccggtgac ccggcgcgtg cgctcggacc gccgccggat ggcagttact ccttcaacca
3910021 ggccggagtg tccggggtga cgtggacgat taccgcgctg tgcgatcagc cgtcgggaac
3910081 ccgtaacatg aacgactatt ctgaccccat cgtttgggcg ttcaactgcg ctctcaacgt
3910141 ggtgagtacg acgccccaac agatcacccg tacggaccgg ctgcagaact tcagcggcag
3910201 ggctcggatg agtagcatgc tgtggacctt ccaggtgaat caggcagacg gcgtggcgtg
3910261 tccggacggc agcacggcac cgtccagcga aacctatgcg ttcagcgacg agacgctgac
3910321 cgggacgcac accaccgtgc atggcgccgt gtgtggcctg cagccaaagt tgagcaaaca
3910381 accgttttca ctgcagctca tcggcccgcc acccagcccg gtccagcgtt atccgttgta
3910441 ctgcaacaac attgcgatgt gctattaaat cggcgtgatg taggcgatca gccatttgcc
3910501 gtcaatccgc tggaaatcca cccgcagtcg gctgccgtcg tagagcggct gtcgcgtctt
3910561 gtcggtcacg gtgcggttca aatagaccat caccgatgcg caatcgcgtt tggcatccat
3910621 gactcccaca ccgacgacat tggcctggac caccacttca cgcttcttcg cctccgggat
3910681 gatctgcgca ttggcgctct tctggaactc ctggcgatag tccggcgtca gcagcgggta
3910741 caccgcggtg aggctgcgct cgacagtttg gtagtcgtaa ccgaagactt gtgggatttc
3910801 ctgcatggcc agcttcggta acagtgcccg cgccgacgct tcgcccccgg tctgcacccg
3910861 gtcccagtag aaccagccac cggccgcgga caaacccacg atggtggcga ccatcagcgc
3910921 gtaggcgacg gaaatcaacc gtctcatcag ttgcccccgt ccgggtactt caggtcgtag
3910981 ccggtcatcc ggccgttctc gtcctcatgc acgatgaccc gaagacgata gggcatggac
3911041 ggcttgttga cgccgtcgat atcggcgacc gtcacccgca ccgacaccaa taccgatgcg
3911101 ttgtcgctga tttcgtcaat gccctccaac gcggcgccgt tgacgacggc ctccgatgtc
3911161 gcgttggtgg cccggaatag acccttgagg ttgtccacgt tgttgttggc gttcagcatg
3911221 ccgcgtagcg gcccactggt gccgttgacg aaccggttca cgctctcgtc gatggtgtcc
3911281 ggcgtgtagc tgaacatgtt gaccacggtc tgggtggcgg catcgacaaa acgctggttg
3911341 cgggcttgcc gggcgtccgc atcccggttc tgcataacca gtgcggtcac accccatgcc
3911401 agcgcggcaa tcgccaatag gcctgccgcc agcgaaagcc agccgaccag gacgcggtgt
3911461 gccggccggc gtggcggcgg tttgaccggc ctcagggcgg gcttggcggc tttcgccggc
3911521 ttcgattcgg tccgcgccgc ggccctcacc gtcgccgcac cctgggcggg acggctcgac
3911581 tcgccttccg ccggacccgc ggggcgggac gccttacgac gagcgcgccg cgtcgtcgac
3911641 tgctgtccgc cggctacacc ggtatctgcg gccactacag ctgcctcgga tcgcgcatga
3911701 gatccaccca attctcggcg ctggatgcgc ccgtcatccc gggcgcgaag ataccagtgc
3911761 cgccggccgg gtccgcgaag gctccgctga gttggtcata gatggtgtag gccggaccgc
3911821 tggcctgcgg ttgggggcca ggcgccggcc cgggcggagg cccggtgcct tccggtggtg
3911881 gcggcggcgg aatggtcgcc gggtatggca cctggggtgg ctccggcggg tacccgggcg
3911941 gcatccatga cgtgaacggt ggaggcggac cgttgtcgtt gggcggcggc gcaggctgcg
3912001 ccggctggtg cggcgccggc ccggggccgg ccacctggcc gggtggcggc ggtccgacga
3912061 tgggcacgcc cgggtcggga tccgcgcccg gcgggatgta agggaacttg ttgggcggca
3912121 gaatgtttcg cccatccgtc acctcggtgc cgtacgggat cggcggaccg cgccacgggt
3912181 tggttccaac tggcacatag ccacgcggat cccgacataa ctgcaccgtc ggtgcccgct
3912241 taccggggaa ttcctggcac gggtagttgc gagcgccgcg caccgtgctc gggtcgttct
3912301 gcgcggtctt gcagtacatg tcccggggaa tctcgcgtac cgactcgtcg gccggcgacc
3912361 ggaccagcgg cgggggcaag aacccggtca tgcagggcgg cgggtcgtgc aggtcgatct
3912421 tgaagtccag cttggcgccc tcgtcctggg gtacgccgcc cgccgaggtg atgatcgcgg
3912481 cgaacagcgc cgggaaaacc accaggagct gttcgatcga cttgtgatag atcacgccca
3912541 cccggcccag gttggccaga ctggccgcca gcgcgggaaa cgaaggacga atcccggaga
3912601 acgcggtgtt ggcctcgtcg atcgcatccg gggcgtcggc caacgtgtcg cgcagccgcg
3912661 ggtctgccgc acggagctgc caggtgaacc gcgccagccc atcggcgagt gacttgatgt
3912721 ccccgccggc gcggatctgg gcttgcagga acgggccggc ctgatcgatc aactgcgaaa
3912781 cctgtggata gttggcgttg gcctcatcca ccagcaaccg ggccgactcg atcagccggg
3912841 ccagttccgg accggcgcca ttggtcgcga tgaacgcctc gtgcagcagc tcccgcagcc
3912901 gggtgtcgcc aaggctgccg agcagcgtct cggcctgacg caacaggtcg gcgacgtctt
3912961 gcccgattcg ggtgttctgc cgctggatcc ggaagccgtt gcgcaacttg gtcgacgacg
3913021 ggttctccgg cggcactagg tcgatgtact gctcaccgat ggccgaaacg ctgcgtacgg
3913081 tggcggtgac gttcgacgga atggcggtgc cactgttcag tcgcatgtgc gcggtaacgc
3913141 cattgggatt tagccccacc gactccaccc gcccgaccgc gacaccgcgg taggtgacgt
3913201 tggcgttctt gtacaggcca ccgcccgcga cgaagtcggc actcacgccg taggttccga
3913261 tgccgaacgt ggcgggcaga cgcagataaa agatcgccat cacgctcagg gtgatgacgg
3913321 tgatcaccgc aaaaatggac aactggatct tggcgagtcg gtcgatcatg tccgggcccc
3913381 tactgtcccg acgccgtacc gggtggaatc ttaaatgggt cggccgcttg cccggacagg
3913441 ttggccagtt cgccaatcag gaagtcgggc gggttgagga tctcgtccat gtgcgccatg
3913501 ttcgggtcga agtacgccgt ggtgaagaac gtctcaccaa tccggcgcag ggtgaggtcg
3913561 aaggtggtga acacgttaag atagtcgccg cgcaccgcct gcttgatacc gaagttggga
3913621 aatgggaacg tcagcaacag ctgcagcgag gtgacgaaat cctttcggtc gtcgttgagg
3913681 gccttgacga tcgagtagag gtctttgagg tcttcaccga aatccacctt ggtctcggcc
3913741 agcacgtgcg acgtgaccat cgtcaacctt ttgagcgcgg cgaacgcgtc gacgatgtgg
3913801 tcccggttct ggttgagcac gcgaaccgcg tcgggcagcg tgtccagtgc tcggcccagg
3913861 ttgtccttgt cacgtgccag gatcgcggag actcggttca gcccatccaa cgcatcgatg
3913921 atgtcgtgaa cctgccggtt caggcccgcc gtcaactccg cgagcctggg gaccaggttg
3913981 acgaactggg cctgccgacc cgccaccgcc tggtgggtct cgtcaatgat ctcttccaac
3914041 gcaccgacgt tacccttgtt gaccaccacc cccagcgccg agaaaacctc ctcggtggtg
3914101 gggaatcggt cggtgttggc ctcggtgatt ctcgagccgt caaccaacct cccggtcggc
3914161 gggcggtccg tcggtggcgc cagctctaca tgtaacgaac ccagcagcga ggtctgggag
3914221 accttcgcca cggcgttggc cggcagcaac acattcttgt ccaggtccag cttcacggcg
3914281 gcataaaagg atccgtcggg tcgttggacc gcgacaatgc cggccacgct gccgacggtg
3914341 acgtcatcga ccatgaccgg tgagttctgc ggcaacgtcg ccacatcagc catttcgacg
3914401 gtgaccgagt aggcaccttc accgtgcccg gcggtgccag gcagcggcag cgagttcagc
3914461 ccgccaaact gacagccggc aagcagcgcg ctgctggccg tcaatatgat ggcgcgcaac
3914521 cagattcggt tcatccgccg cccccatgct cgcccggtcc tgcccccggc gccggcgggg
3914581 ccggtgccgg accgggcgcc ggtgggacga gtaggctctg cagatccgcg gggttgccca
3914641 caggcgctcc tcctcccgcg ggtacccaag tcaattccgg aaccggcgtc tccgacttgg
3914701 cctcggtggc cggggtgtcg tagatgatct ggcccttgta cgccgtgatc gtgttaagcg
3914761 ggtggaacat gatcggcggg taattcaccg tgagccggcg cagcaccggc cccagccgct
3914821 cacggcagat ctcggcgcgc cggtagtagt ccggcgccga cgggcccgcg gcggtatcga
3914881 aggaaccgcc gcagatgaac tgcaccgggt tagcgaagtt gggtatcgac aacagaccgt
3914941 tgagggtgcc ttgcgcaggg tcatagatgt tgtagaagtt ggtgatcccc ggcccagcca
3915001 cgtgcagcac ttgctcgatg ttctcgctct ggtcactcaa cgtctgcgca aagtcgttga
3915061 gctgattcac cgtttcgatc agcgtcgagt tgttctcgcg caagaacccc ctgatgtcgg
3915121 acagcgcctg gttgagcgtg cccagggtct ggtccagatt ggccgagctg tcggcgagca
3915181 cctgcgacac cgatgccacg tggccggcga actgcacaat ctgctcgtcg ctctccgata
3915241 gcgcgtcgac cagtacctgc aggttcttga cggtgccgaa gatgtcgccg cgcgaatccc
3915301 ccagccgccc ggcgacctgc gcaagctcgc gcaacgcgtt gtgtaacgag tctccgttgc
3915361 cgtcaagggt gtccgcggcc tggttgatcg ccgcgcccag cggcccctgc agctcgcccg
3915421 ccgccggact caggtcggcg gccaaccggg tgagcccctc tttcacctcg tcccattcca
3915481 ccggcaccgc ggtgcgatcc agatcgatcc gaccgttgtc gggcagtacc gccccgccgg
3915541 tatacaccgg ggtgagctga atgaagcgcg ccgccaccaa attcggcgac atgatcacgg
3915601 cctgcacgtc cacgggcacc ttgacgtcct tggacaccga catagtgatc ttgacgtcgg
3915661 acgaccgcgg ctcgatcatg tcgatctcac ccaccgggac gcccaggacg cggacctggt
3915721 caccgggata gagcccgaca gcagaggtga agtagcccac gatggtgcgc ttattaccgg
3915781 tggacgagag cacgtacacg ccgcccacca gcgcggccac cagcgcgatc accgtggcgt
3915841 agcgcaatcc ccggctcccc gtcaacatgg cgacccggcc catcacggcg acttcggtct
3915901 gatgatccag cgctcctgga taaacccgcg caagtaatcg gcgaggctat ccggcagctt
3915961 gcccggctga aagaccaggt cgaacacggt cgccaccagc ggcccgggca gcacgctgta
3916021 gacgttgaca ttgaatccgg gtccggatcc gaccacctcc cccagcgtgg tcgcgtacgt
3916081 gggcagccgc ttgagggcct cggtgatata gtcgcggcgc tcgttgaggt tggccagcac
3916141 caggttgagc ttgctcaaag ccgggccgaa ctccttacgg ttgtcggcga caaagccgga
3916201 aatctgcgct gcaacatcgt cgatcccaga gatcaacgcg ctgagcgcgg cccgccgggc
3916261 atcgagcgcc gcaaacaact ggttgccgtc ctcgaccagc ttgttgacct gttcggcgcg
3916321 ttcggacaac accgatgtca ccgacttggc gtgcgccagc aggccttgca gcgcttcgtc
3916381 gcgacgattc agggcgcgcg acagcgacgt cagcccgtcc acggcaccac gcacctgcgg
3916441 ggtggcgtca tgcaaggcct gggtgaacac gttcaaggcc tgctcgaact gcggcctatt
3916501 caggtcgttg gcgttgcggc ccagatcctg cagcaccccg ttgagcgtgt agggcgtggt
3916561 ggtccggctc aacggaatcg tggtcgactt gccggagcca gccggactga ccgcgatgga
3916621 gcgctcgccg aggatggtgt cggtgcggat cgcggccagg gactggtcgc cgacgacgat
3916681 gctgcggtcc acgctgaagg tgacctttgc actgtttccg gccagactca cggccgacac
3916741 cgcgcccacc ttgaggcccg agacataaac cgagttaccg ggggtgatcc caccggcgtc
3916801 ggtgaaatac gcgtcgtagg ttttgccctg tggccagaaa ggcaacccgc tgtagccgaa
3916861 tgcgatcagg acgacgcaga tcaccagcac caggccgaag atgccggtgc ggagcgggtc
3916921 gcgttcgtgt ttgctacttg gcttcctatt tagcaaaggc gcacctcccc ttgctgggat
3916981 ccggctggcc gccgatcggc agcaggatgt cgctgccggc cggtccgttg atcttgatcg
3917041 tcaccgagca gaagtagatg ttgaagaatg ctccgtaact gcccagcgcg gacaggcgca
3917101 ggtagtcctc gccgagctgc tcgatgtcgt tgttgacctc ggcctttcgg ttgtccagct
3917161 cggtagccag cggccgggcg ttttccagga tgccttgcag cggccggcgc gaattccgca
3917221 acagttccgt aagatccgtc gtcgtcgacg ccagcggcga aatggcgccc gcgatcggat
3917281 cccggttctt ggccaggccg ctgaccagct gctgcagctg gtcgacactg gccgaaaatt
3917341 gcgcgctctt tgcatcgacg gtcgccagca ccgcgttgag gttggtgatt acctcgccga
3917401 tcagctggtc gcgtgcgccc agcgccgccg agaaggcacc ggtgtcggcg agcacgttcg
3917461 ccaacggacc accctggccc tgcagcaact cgatgaccgc actggtgatg gtgttgatct
3917521 tgtcagcgtc aaagcctttc agcaccggcc gtagcccacc cagcaacgca tcgagatcca
3917581 gtgcgggctg ggtgtgggcc acgttgatgg tgccacccgg cggcagcttg cgcagttcac
3917641 ccggacccga cgtgatctcc aggaaccggt cgcccaccag gttttcgtac cggatcaccg
3917701 cacgcgtgga cgagtacagc gtgtagctgc ggtcgatcgc gaatgccacg tcgatgctgt
3917761 ggtctgggtt gagcttgacc gccttcactg aaccgaccgg cacaccggcg atgcgaacct
3917821 tctggcctgc cttcagccgc gacgcgtcgg tgaaggtggc gtggtagacg gttgtgggac
3917881 caaaccggaa gtccccgaag accaccacca gaccggcggc caccagcagc atgaccaccg
3917941 cgaagacgct gaccttgatc accatcgacc ggtgcgaggg aacgcccgag cccgccatca
3918001 gaagtcgtcc cgttccgcga acgcaccgtt gaacaggaac tgcagcgtcg acggcgcgtc
3918061 aacctgtaac tcggtgaacg gctggtatgg gatcaaagcg ttgtcggtga ccaggaacgg
3918121 cgcgcggtag aacgacccgc ccgtctgctt ggtcgggata tcgggcaacc ctcggcagtt
3918181 cggaccgccg gaggcgttga cgatcggcag gctctccgga taggtgtacg acggcgcacc
3918241 caacacgaag ctcgacgagg tgaacagccc agccttacgg acaccgatta gcggggcaaa
3918301 ctccttgaca ccgcgcgcga tgcccttgaa aaggcagccg aataccgggg agtagtcgga
3918361 ggtcactttg agcggggctc ggagccggtt gatggcgtcg atgaaattct gttcggcggg
3918421 cgccaacgtc tcataggcgt tattagacag accgatggtg gctagcagcg tgtcgttgag
3918481 gttgtccttc tggtcgacga tcgtcttgtt gatcgtcggc aggttatcga acacggtgtt
3918541 caggtccccg gcggcgtcag catagacgtt ggccaccacc gccgccttgc ggaaatcctc
3918601 ctgaagggcg ggtaactttg ggttcgcttg gcgggtcagc gtgttcagtc ccgacaacag
3918661 cgcacccagg tcatcgccgt ggccgcgcag gccttcggac agcgcgctca gcgtcgcgtt
3918721 cgtttcaagc ggatcgatct tgtgtagcag gtcgatgagc gattggaaca acgtgttgac
3918781 ctcaagctgt acctgagacg ccgccacgtg cgcattcgga cttagcggct tgggcgacgg
3918841 cgtctttggc ggaatgaatt ccaccgattt ggcgccgaag atggtgtttc cggcgatgcg
3918901 caccgtcgcg ttggagggga taaaacccat ctcgccgctg tcgatggcca gcttgagccg
3918961 tgcttggttg ccgctgtagc tgatatccgt gaccttgcct acctggatgc cacggtattt
3919021 gaccttggcg cccttctcca taaccaggcc ggccctcggc gacgataccg tgacggtgtc
3919081 cgtagacgtg aaagccgccg tatacgaaag ataagtcagc actgcggatc ccaccatcag
3919141 cccggccagc agcgccgctg ccaccctgac actggtgcgt cgagatccgc cgccggacat
3919201 gtttcctttc tgaaggtttt taccccgaga ggttgaagtt accggacgcg ccgtagacgg
3919261 cgagcgagat gaacaaggtg atgacaacaa ccacgatcag cgaggtccgt acggcctgcc
3919321 cgaccgcgac cccgacccca accgacccgc cgctggcgtt gtagccgtag taggtatgca
3919381 ccagcattac cgcgatcgac atagcgatgg cttgcataaa cgaccacaac aggtcggagg
3919441 ggatgaggaa ggtgttgaag taatggtcat aaaggcccgc ggactgccca ttgacgaaca
3919501 ccgtggtgaa acgagcggcg aagaacgcgg ccagcaccga caacgaatac aacggaatga
3919561 tcgccaccag gccggcgatc agccgggttg acaccaaata ggacaccgag tgcaccgcca
3919621 tgcattcgac ggcgtcgatc tcctcagaga cccgcatggc acccagctgc gcggtggctc
3919681 cggccccgat ggtggccgcc agcgcgatac ccgcgatcac cggcgcgaca acgcggacgt
3919741 tcaaaaacgc cgacaggaac ccggtcaacg cctcgatacc gatgtcgccc agcgacgaat
3919801 acccctgcac ggcgatcacg ccaccggacg ccagggtcaa aaaggccgcc accccgaccg
3919861 tgccgccgat catgaccagc gctccggcgc ccagcgtcat ctcggcgacc agccggaccg
3919921 tctccttccg gtagcgggtg atggcgttgg gcacatagcg catggtttcg ccgtagaaca
3919981 gcgcctgctc accgaagttg tcgaccggcc gctgcagccg cgaaaagaaa cggcgaaacc
3920041 ggatagtgac gtcgtagctc atcgcttcat caccatcgct cgctcaccgt cgtttgttac
3920101 tgcgccgaga ttcgcacacc tatagcggtc atgactacgt tgatcacgaa aaggcagatg
3920161 aacgcgtaga cgacggtctc gttgaccgca ttgcccaccc ccttgggccc acccttgacc
3920221 gtcagaccgc ggtaacaccc gaccagcccg gccatgaccc cgaacagtag cgccttgatc
3920281 tccgccagta tcaattcgcg cagtccggtg agcacggtca gaccgttgat aaacgcaccc
3920341 gggttgacgc cctgaagaaa gaccgagaac gcgtagccgc cggacaggcc aatggcgcac
3920401 accaagccgt tgagcagcag cgcaaccaat gtggacgcca acaccctggg gaccacgagc
3920461 cgttgaattg ggtcgatgcc cagcacccgc atcgcgtcga tttcctcacg gatggtgcga
3920521 gcgcccaggt cggcgcagat cgccgtggcg ccagcacctg ccaccaccag cacagtcacg
3920581 accgggccca gctgggtgat ggtgccgaac gccgttccgg cgccggacaa gtcggcggcc
3920641 ccaatttcac gcaacagaat gttgagggtg aacgccacca ggaccgtgaa cggaatggac
3920701 accagcaacg tcgggactag cgaaacgcgg gccaccatcc aggtctggtc caaaaactcg
3920761 cggaactgga acggccgccg gaaagcggca cgcgcggtgt ccatcgacat ttcgaagaac
3920821 ccgccgacgg cccgggccgg aaccgcaagt tgttggatca actggggtcc ccccgtctac
3920881 tgctcgcggc gaagtctgtg agtctcctga acgcgcttag ggcccgcacg ttgcacggtg
3920941 tgagccggcc catcctaacc cagaacgagt ttgcggtgtc aacgaaccgc acaccggatc
3921001 aactgggtca atttcgctgg ttaagcccta tgttggcgtg gtgattcgga caccgattcc
3921061 aataatcggc cgcctatatc cacgggtcac tgacgcatca gatcggtcgc cgaaaagctc
3921121 tgttccggat cccgaccagc aaagtagtcc cgcagcgtcg cggtgagctc ggtgggatcc
3921181 caggacgtgc cgtccgcgct gaaccggcgc tccatgtgcg gcggtgacac cagcgtcacc
3921241 tgcggaccgt agacgatgaa cacctgaccg ttgacttccg cggcagccgg ggacgccaga
3921301 aactggacca ggcttaccac atgctgcggc gacagcgggt cgatctggcc cgcttcgaca
3921361 tcgggtgcgg cgccgaagac atcggccgtc atcgcggtgc gcgcccgcgg acaaatcaca
3921421 ttggcgcaaa cgccgtagcg cccgagcgcc cgcgccgccg acagggttag cgcggtgatg
3921481 ccagccttgg cggcggcgta attcgcctgc cccaccgggc ccaccagacc cgcctccgac
3921541 gaggtgttga cgagccggcc gaagaccgat cccccttcgg catccttggc tttgtcccgc
3921601 cagtaggcag cggcgttgcg ggtgagcaga aaatggccgc gcaggtgcac cgcgatcacg
3921661 gcgtcccact cctcgtcgga catgttgaac agcatccggt cgcgggtgat gccggcattg
3921721 ttcaccacga tgtccagtcc gcccagcccg acggcgctgg cgagcagttc gtcggccgtc
3921781 gcgcgctggc tgatatcacc ggctaccgcg acggccttag caccagcatc ggcagcggcg
3921841 gcgccgatct cgtcgacgac gtcggaagca tccagggcgg aagcaacatc gttgacgacg
3921901 acggtggcgc ccaaccgggc caggccgagc gcttcggccc gacccaaacc cgcggccgcg
3921961 ccggtgacca ccgccacctt tccggacaga tcggtcgtgt tcgtggtacg cggcgagcga
3922021 ttggactcag tcaatttcaa tttatgaata cctctagttc cgtcctactc accacgcgac
3922081 aacgccgcac gcgggcattc cgcgatggcc tgctcggcca gatcctcctg atcaaccggg
3922141 atcggatcgg tcttgaccac ggcatagtcc tcgtcgtcca ggtcgaagat atccggtgcg
3922201 attcccaagc acaccgcgtt gccttcacat cggtctcggt ccacgatcac ccgcacggca
3922261 ccctccttac cctgaccatc cccccggtcg ctgctagttc caccataagg ccctgctaca
3922321 tccgaggaaa cggtcgctgg attcagagac tagaacgtgt tacaaccggg aagacggccg
3922381 ggttgccgtt ggcgttggtt gtcgacagct agtggacggc tgctgacggc cagtgataaa
3922441 gacgcgatca ttcaatcgga ggcagctgag atgcgcatca gttacacccc gcagcaggag
3922501 gagctgcgcc gcgagctgcg ctcgtacttt gccacgttga tgacgccgga acgccgggag
3922561 gcgctgagct cggtccaggg tgaatacggc gtcggcaatg tctaccggga gacgatcgcg
3922621 caaatgggcc gcgacgggtg gcttgcgctg ggctggccca aggaatacgg cggccagggc
3922681 cgctcggcga tggaccagct gatcttcacc gatgaagccg ccatcgccgg tgcaccggtg
3922741 ccgttcctga ccatcaacag cgtggcgccg acgatcatgg cctacggaac cgacgagcag
3922801 aagaggtttt tcctgccccg gatcgccgcc ggggatctgc acttctcgat cggctactcc
3922861 gagcccggcg ccggcaccga cctggccaac ctgcgcacca ccgcggttcg cgacggcgat
3922921 gactatgtgg tcaacggcca gaagatgtgg accagcctga ttcagtacgc cgactacgtc
3922981 tggttagcgg tacgcaccaa cccggagtct tctggggcca aaaaacaccg tggcatatcg
3923041 gtgttaatcg tgccgacgac cgctgagggc ttctcctgga ctccagtgca caccatggcc
3923101 ggtccggaca ccagcgccac ctactactcc gacgtgcggg taccggtggc caaccgggtc
3923161 ggtgaggaaa acgccggctg gaagctggtg accaaccagc tcaaccacga gcgggtcgcc
3923221 ctggtgtcgc cggcaccgat tttcggatgc ctgcgcgagg tccgcgaatg ggcacaaaac
3923281 accaaggacg ccggcggcac caggctgatc gactcggagt gggtgcagct caacctggcc
3923341 cgggtacacg ccaaggccga agtcctcaag ctgatcaact gggagctggc ttcctcgcaa
3923401 agtgggccga aggacgctgg accgtcaccg gccgatgcgt cggcggccaa ggtgttcggt
3923461 accgagctgg ccaccgaggc ctaccggctg ctgatggagg tgttgggcac tgcggcgacc
3923521 ctgcgccaga attcgccagg cgcgttgctg cgcggccgcg tcgaacggat gcaccgggcg
3923581 tgcctgatcc tgacgttcgg cggcggcacc aacgaagtcc agcgcgacat catcggcatg
3923641 gtcgcgctgg gactgccgcg agccaaccgc tgagcggacc tgagaggaca agacgtcatg
3923701 gatttcacga caaccgaagc cgcccaggat cttggtggtc tggtcgacac catcgtggac
3923761 gcggtgtgca cgccggagca tcaacgtgag ctggacaagc tcgagcagcg gttcgaccgc
3923821 gagctgtggc gcaagctgat agacgccggc atcctgtcca gtgcggcgcc ggagtcgctg
3923881 ggcggcgatg gcttcggcgt gctcgagcag gttgcggtgc tggtggcgtt ggggcatcaa
3923941 ctggccgcgg tgccgtacct ggagtcggtg gtgctcgccg ccggcgccct ggcccggttc
3924001 ggctcgccgg aactgcagca gggctggggg gtgtcggcgg tctccggcga tcggatcctc
3924061 accgtcgccc tcgacggtga gatgggcgag ggtccggtgc aggccgccgg caccggacat
3924121 ggctaccgcc tcaccggcac acgcacccag gtcgggtacg gcccggtggc cgacgcattt
3924181 ctggtacccg ccgaaaccga ttccggtgca gccgttttcc tggttgccgc cggcgaccca
3924241 ggggttgcgg tgaccgcact ggccaccacc ggactgggca gcgtcggaca cctcgagcta
3924301 aacggggcca aagtggacgc cgcccgcagg gtcggcggaa ccgatgtcgc ggtttggctc
3924361 ggcacgcttt ccaccctgag ccgcaccgct tttcagctcg gtgtgctcga gcgcggactg
3924421 caaatgacgg ccgaatatgc gcgcacccgt gaacaattcg accgcccgat cggcagcttc
3924481 caggcggtgg ggcaacggtt ggctgacggc tacatcgacg tcaagggatt gcgactgacg
3924541 cttacccagg cggcctggcg ggtggccgaa gattccctgg caagccggga gtgcccccag
3924601 ccagccgaca tcgacgtcgc caccgcgggg ttctgggccg ccgaagccgg gcatcgggtg
3924661 gcgcatacca tcgtgcatgt gcatggcggc gtcggcgtcg acaccgatca tcccgtacac
3924721 cggtatttcc tggccgccaa gcagaccgag ttcgcgttgg gcggcgccac cggtcagctc
3924781 cgccgaatcg gccgtgaact ggcggaaacc cctgcctagc cctgcctagc ccggcgacga
3924841 tgcggtccgc gcagcggacc gagaaggagc gggcgaatcg aacccaccga tgactcccac
3924901 tcacccgacc gtcaccgaac ttctgctgcc gctatccgaa atcgacgatc ggggcgtcta
3924961 tttcgaggac tcgttcacca gttggcgcga ccacatccgg cacggtgccg caatcgccgc
3925021 agcgctgcgg gaacgcctgg acccggcgcg gccgccacac gtcggtgtgt tactgcagaa
3925081 cacgccgttc ttctcggcga cactggtggc cggcgcgctg tcggggatcg tcccggtggg
3925141 cctcaacccg gtgcgccgcg gcgcggcact ggccggcgac atcgctaaag ccgactgcca
3925201 gttggtgctc accggctcgg gatcggcgga ggtaccggcc gatgtcgagc acatcaatgt
3925261 cgactccccc gaatggaccg acgaggtggc cgcacaccgg gataccgagg tgcgttttcg
3925321 atccgcggat ctcgcagacc ttttcatgct gatcttcacc tcgggcacca gcggcgaccc
3925381 gaaggcggtg aagtgcagcc accgcaaggt tgcgatcgcc ggcgtgacga tcacgcagcg
3925441 cttcagtctg ggccgcgacg acgtctgcta cgtctcgatg ccgttgttcc attccaacgc
3925501 ggtgctggtc ggctgggcgg tggctgcggc ctgccaaggc tcaatggcgt tgcgacgcaa
3925561 attttcggcg tcgcagttcc tggccgacgt ccgccgttat ggcgccactt acgccaacta
3925621 cgtgggcaag cctctttcgt atgtgcttgc gacaccggag cttcccgacg acgcggacaa
3925681 cccgctgcgg gcggtgtacg gcaacgaggg agtacccggt gacatcgacc gtttcgggcg
3925741 caggttcggc tgcgttgtca tggacggctt cggctcgact gaaggcgggg tggcgatcac
3925801 gcggacactc gacaccccgg cgggcgccct gggcccactg ccggggggaa tccaaatcgt
3925861 cgaccccgac accggcgaac cgtgcccgac aggagtggtc ggcgaactgg tcaacaccgc
3925921 cgggccgggc ggtttcgaag gctattacaa cgacgaggcc gccgaggccg agcggatggc
3925981 cggcggcgtc taccacagtg gcgacctcgc ctatcgcgac gacgccggct acgcctattt
3926041 cgccggtcgg ctcggcgact ggatgcgagt cgacggtgaa aatctaggca ccgcaccgat
3926101 cgagcgggtg ctgatgcgct acccggacgc caccgaggtc gctgtgtatc cggtacccga
3926161 tccggtggtg ggtgatcagg tgatggccgc gttagtgttg gcgcccggca ccaaattcga
3926221 tgccgacaag ttccgggcgt ttctgaccga gcagcccgac ctggggcaca agcagtggcc
3926281 gtcgtatgtg cgggtcagcg cggggctgcc gcgcaccatg accttcaagg tgatcaagcg
3926341 ccagttgtcg gccgaaggtg tcgcctgcgc cgatccggtg tggccgattc gccggtagcc
3926401 tcacggcgcg ccaccatgct caccgggatc tggccggatg gtggacccga ataatcgggt
3926461 agaaccgccg aatgagctgc ccggatcgcg atacgatcca ttcctagcaa ttgcaccgat
3926521 gatgcacggc cgcggccggg ttcggcttgg gctggtgcga ggtaccggat gtcgtttgtg
3926581 ttggtttcgc cggagaccgt ggcggcggtg gccacggatc tcaagcgcat cggcgcctcg
3926641 ctggcccacg aaaacgcgtc ggcggccgct tcgacgacgg cggtggtctc cgcggccgcc
3926701 gacgaggtat cgacggcggt cgccgctctg ttctcccaac acgcccaggg ctaccaagcg
3926761 gcggccgctc aggtagcagc gtttcatagc cggtttgtgc aagccctgac ggccggtgcc
3926821 ggggcgtacg catttgccga ggcggccaac gcgtcgccgc tacagtcagc catgggtgcg
3926881 gtaagcgcgt ctgcgcagac gctgttgtcg cgcccgttga tcggcaatgg cgccaatgcg
3926941 acgacgccgg gcggtaacgg cggcgacggc ggatggctat tcggcagcgg cggcaacggc
3927001 gcgcccggcg cggcgggcca gtccggcggt aacggcgggt cagccggact gtggggtaac
3927061 ggcggcgcgg gtggcgccgg cggcagcggc ggcgccgccg gcggcaacgg cggtaacggc
3927121 gggtggctgt tcggcgccgg cggcaccggc ggtatcggcg gcaccggtgc tcccggcgcc
3927181 atgggcggca ccggcggcaa cggcggcaac ggcgcgctgc tgatcggcgg cggcggcctc
3927241 ggcggcgccg gcggcatggg tggcaccggc ggcggcaccg gcggcaccgg cggcaacggc
3927301 ggcaacggcg cgctgctgat cggcgctggt ggtgtcggag gtgctggcgg gatcggtggc
3927361 cagggtaccg gcgccggcgg tgccgccggc gccggcggca ccgggggcaa cggcggcgcc
3927421 ggggggttgt tcatgaacgg cggcgacggc ggcgccggcg gtcaaggcgg cgacggtgcg
3927481 gccggcgacg cggctgccag cgccggcggc accggcggca aaggcggcca aggcggcgac
3927541 ggcggcaccg gaggggccgg cggcgcaggc ccagtgctgt tcggccacgg cggcgccggc
3927601 ggcatgggcg gccaaggcgg caccggtgga atgggcggcg ccggcggaga cggcaccacc
3927661 gtcatcgcgg ccggtaccgg gggggagggc ggcaccggcg gcgcggccgg cgccggcgga
3927721 gccgcaggcg ctcgcggggc tctcaccagc ggcggcctag ccggcggcgt cggggccggc
3927781 ggcaccggcg gcaccggcgg taccggcggc aacggcgctg acgccgctgc tgtggtgggc
3927841 ttcggcgcga acggcgaccc tggcttcgct ggcggcaaag gcggtaacgg cggaataggt
3927901 ggggccgcgg tgacaggcgg ggtcgccggc gacggcggca ccggcggcaa aggtggcacc
3927961 ggcggtgccg gcggcgccgg caacgacgcc ggcagcaccg gcaatcccgg cggtaagggc
3928021 ggcgacggcg ggatcggcgg tgccggcggg gccggcggcg cggccggcac cggcaacggc
3928081 ggccatgccg gcaacacagg tgacggcggc gacggcggga ccggcggtaa cggcggcaac
3928141 ggcaccggag gcgtgaacgg cgccgacaac accctcaacc ccgacacccc cggcggcgcc
3928201 ggggagcccg gcggggccgg cggggccggc ggggccggcg gggccgccgg cggcccgggc
3928261 ggtaccggcg gtaccggcgg taacggcggc aacggcggca acggcggcaa cggcggcaac
3928321 ggcggcaacg gcggcaacgg cggcaatgcc ggcaacaaca gcaccaatgc cccagtcggt
3928381 ggcgaaggcg gcgccggcgg cgacggcggc gccggcggcg caggcggggc cgccaacggc
3928441 ggcaccgcgg gcagccaggg cactgggggc gtcggcggcg acggcggcgc gggcggcaac
3928501 ggcggcggcg gcaaggctgg caccggcaac agcggcaact ttggggtgga cggcgaagcc
3928561 ggcttcagcg gcggcgccgg tggcaacggc ggcgtaggcg gggccgccgg cgccaatggc
3928621 ggaaccggcg gcagcggtgg taatggcggt gacggcggtg cgggaggcat tggcggggcc
3928681 ggcggcaacg gcataccggg cactggcaca gagcctgccg ggggcaccgg cgccaaaggt
3928741 ggagacggcg gcgacggtgg cgccggcggc gcaggcggca atgccggcgg ggccggcggc
3928801 cagggcggca atgccggcca gggtggcgcc ggcggtgcgg gcggcaacgc cgtgattccc
3928861 ggcgacggcg tcgggaaggc gccgcacggc gacgcgggcg gcagcggcgg agacggcggc
3928921 aaaggcggcc agggcggtag tggcggcacc ggcggatccg gtgccccgat cggtggcggc
3928981 gccggaggca ccggagggtc cggcggacac gccggcaagg gtggcgccgg cggcatcggc
3929041 gcacagggca ccaccatcac cgtgcccggg aacggcggca acgccggcga cggcggcaac
3929101 ggcggcaacg ccggcgccgg tggaaacggc ggctccggcg acttcggtgg caataccacc
3929161 agcggcgcct ccggcagcgg cggcaacggc ggcaacgccg gcaccgcggg tagcggcggt
3929221 gcgggcggaa ccggcggcac cggccttagc ggcggcaacg gtggcaacgg cggcaacggc
3929281 ggcaacggcg gtgacggcgg taacggcgcc cacggcaccg tcggcgccca gttcgtcccg
3929341 gccaccagct tgcccacacc caacggcggg gccggtggca acggtggcac cggaagcaac
3929401 ggcggcgcgc ccggccccgc cggggcgccc ggccccacta ccggcggtaa cgctggcagc
3929461 cagggcatcg gcggcgacgg gggcaacggc ggcgacggcg gtaaaggcgg tgacggcgcc
3929521 gacgctgtca acgtcgtatt catgccgact gagccacagg ccgcgaccgg cactgccggc
3929581 agcgccggtg accccaccgg cggtaacgga gggcccggca ctcccggcag ccccatggtt
3929641 gccccgcccc cgccaacgcc aatcactcaa gtccaacagg gcggtgacgg tggcgccggg
3929701 ggcaccggat ccaccaacgc caacgacggc acagccaccg gcggaaaggg cggagaaggc
3929761 ggagtcggca gcattctcgg cgggcccggc ggcaacggcg gaactggcgg caacgcctcg
3929821 gcaaccggca ccaacggggt ggccaacgcc gggaatggcg gcaagggtgg cgacggcggc
3929881 cagtttgggg ccggcggcaa cggtggtgcc ggcggcagcg taaccgacgg atccgccggc
3929941 agcaccgcag gcaacggcgg caacggcggc aacgcaacca acggcaccat cgcaggccaa
3930001 cccgccggcg gcaacggctc ggccggcggg aaaggcggcg acggcggcaa catcgccgcc
3930061 ggtgccaccg gcaccgccgg caacggcggg aacggcggca acggcaacga cggcgccgtc
3930121 aacgccggca ccggcggctc cggcgggaac ggcggtaacg ccggtggcgg cggcgccaat
3930181 ggcggcgacg gcggcgccgg cggcgccggc ggggccggcg ggcgtggcgg caagggcatc
3930241 gacggcgggt tcggcggtga cggcggcaac ggcggcagca acaacggcac cggcgccggt
3930301 ggcaacggcg gcaacggcgg caccggcggg gtcggctcgg ttggcgcggc tggtggcgat
3930361 ggcggcaacg gcggcaccgg cggcttcgcc ggtttcggcg gcaccgcagg caatggcggt
3930421 tccggcggca cgggcggggc cggcggcgac ggcggcaccg gcggggacgg cggcaacggc
3930481 gttatcgccg gcggcggggg gaccggcggc aacggcggcg ccagcggggc cggcggcgcc
3930541 ggcggcacgg gcgggttcgc cggcaacggc aatgccggcg gcaatggcgg caccggcggc
3930601 gcgagcgagg acggcgacaa cggcaacgct ggcagcggcg ccaccggcgg taccggcggc
3930661 aacggcggca ccggcggcga cggcggcgct gccgggctgg gcggcgtcgc gtgaggttga
3930721 ccggcgatca ccgtagccag cacggcccgt gacaccggtc cggcacgcca ccctcgtcgt
3930781 tcaggtggtg tcgccactcg cgctacacaa cgcttcacgg cactcgtcga gacttatgct
3930841 cgagttctga tacgtggagc aactgttttg gcgttcgacc cgtattgcgc aggtggcggt
3930901 actggaaaac gtagacgtgt tgggcgggtg acgaataaga tcctggccta actactgcgt
3930961 caattatgcc gcggtggccg cgccgtccgg ttgggagttc gcccatgtcg ttcgtgttga
3931021 tcgcaccgga attcgtgaca gcagccgcgg gggatctgac gaatctgggt tcgtcgatta
3931081 gcgcggccaa cgcgtcggca gccagtgcga ccacgcaggt gctggctgcg ggcgccgatg
3931141 aggtgtctgc ccgtattgcg gcgctgttcg gcgggtttgg cctggagtac caggcgatta
3931201 gtgcgcaggt ggcggcctac caccagcggt ttgtgcaggc cttgagtacc ggcgcgggcg
3931261 catatgcctc ggccgaggcc gccgccgctg agcagatcgt gctgggcgtg atcaatgcgc
3931321 ccacccaggc gctgctgggg cgcccgttga tcggtgacgg cgccaatgcg acgactcccg
3931381 gcggggccgg cggggccggc ggtctgctgt tcggcaacgg cggggccggg gcagccgggg
3931441 cgcccggcca ggccggcggg cctggcgggc ccgccggatt gtggggcaac ggcgggcccg
3931501 gcggggccgg cggcagcggt gggggcaccg gcggtgccgg cggcgccggt gggtggctgt
3931561 tcggggttgg cggcgccggc ggtgtcggtg gggccggtgg cggcaccggc ggggcgggcg
3931621 ggcccggtgg tttgatctgg ggcggcggcg gggccggcgg tgtcggtggg gccggtggcg
3931681 gcaccggcgg ggccggcggc cgcgccgagc tgctgttcgg cgccggcggt gcgggtgggg
3931741 cgggcaccga cggcgggccc ggtgctaccg gcgggaccgg cggacacggc ggagtcggcg
3931801 gcgacggcgg atggctggca cccggcgggg ccggcggggc cggcgggcaa ggcggggcag
3931861 gtggtgccgg cagcgatggt ggcgcgttgg gtggtaccgg cgggacgggc ggtaccggcg
3931921 gcgccggtgg cgccggcggt cgcggcgcac tgctgctggg cgctggcgga cagggcggcc
3931981 tcggcggcgc cggcggacaa ggcggcaccg gcggggccgg cggagatggc gttctggggg
3932041 gtgtcggtgg cactggtggt aagggcggtg tcggcggcgt ggctggcctc ggcggggccg
3932101 gtggtgccgc gggccagctc ttcagcgccg gaggcgcggc gggtgccgtt ggggttggcg
3932161 gcaccggcgg ccagggtggg gctggcggtg ccggagcggc cggcgccgac gcccccgcca
3932221 gcacaggtct aaccggtggt accgggttcg ctggcggggc cggcggcgtc ggcggccagg
3932281 gcggcaacgc cattgccggc ggcatcaacg gctccggtgg tgccggcggc accggcggcc
3932341 aaggcggcgc cggcggcatg ggtggctccg gtgctgataa tgccagcggg attggcgccg
3932401 acggcggcgc gggtgggact ggcggtaacg ccggcgccgg cggggccggc ggggccgccg
3932461 gcaccggagg aaccggcggg gttgtcggcg ccgcgggcaa ggccggtatc ggcggcaccg
3932521 gcggccaagg cggcgccggc ggcgcgggca gcgccggcac ggatgcgacc gctaccggtg
3932581 ccaccggcgg caccgggttt tccggtggag ccggcggggc cggcggggcc ggcggcaaca
3932641 ccggggttgg cggcaccaac ggctccggcg ggcaaggcgg caccggcggc gcgggcggcg
3932701 ccggtggtgc tggcggtgtc ggcgccgaca accccaccgg catcggcggc accggcggca
3932761 ccggcgggaa aggcggcgcc ggcggggccg gcgggcaggg cggtagcagc ggtgccggcg
3932821 gcaccaacgg ctctggtggc gctggcggca ccggcggaca aggcggcgcc gggggcgctg
3932881 gcggggccgg cgccgataac cccaccggca tcggcggcgc cggcggcacc ggcggcaccg
3932941 gcggagcggc cggagccggc ggggccggtg gcgccatcgg taccggcggc accggcggcg
3933001 cggtgggcag cgtcggtaac gccgggatcg gcggtaccgg cggtacgggt ggtgtcggtg
3933061 gtgctggtgg tgcaggtgcg gctgcggccg ctggcagcag cgctaccggt ggcgccgggt
3933121 tcgccggcgg cgccggcgga gaaggcggag cgggcggcaa cagcggtgtg ggcggcacca
3933181 acggctccgg cggcgccggc ggtgcaggcg gcaagggcgg caccggaggt gccggcgggt
3933241 ccggcgcgga caaccccacc ggtgctggtt tcgccggtgg cgccggcggc acaggtggcg
3933301 cggccggcgc cggcggggcc ggcggggcga ccggtaccgg cggcaccggc ggcgttgtcg
3933361 gcgccaccgg tagtgcaggc atcggcgggg ccggcggccg cggcggtgac ggcggcgatg
3933421 gggccagcgg tctcggcctg ggcctctccg gctttgacgg cggccaaggc ggccaaggcg
3933481 gggccggcgg cagcgccggc gccggcggca tcaacggggc cggcggggcc ggcggcaacg
3933541 gcggcgacgg cggggacggc gcaaccggtg ccgcaggtct cggcgacaac ggcggggtcg
3933601 gcggtgacgg tggggccggt ggcgccgccg gcaacggcgg caacgcgggc gtcggcctga
3933661 cagccaaggc cggcgacggc ggcgccgcgg gcaatggcgg caacgggggc gccggcggtg
3933721 ctggcggggc cggcgacaac aatttcaacg gcggccaggg tggtgccggc ggccaaggcg
3933781 gccaaggcgg cctgggcggg gcaagcacca cctcgatcaa cgccaacggc ggcgccggcg
3933841 gcaacggcgg caccggcggc aaaggcggcg ccggtggtgc gggaaccctg ggcgtcggcg
3933901 gctccggcgg caccggcggg gacggcggcg atgcgggctc tggtggtggc ggcggcttcg
3933961 gcggggccgc gggtaaggcc ggcggcggcg gaaacggcgg ccgcggcggt gacggcggcg
3934021 atggggccag cggtctcggc ctgggcctct ccggctttga cggcggccaa ggcggccaag
3934081 gcggggccgg cggcagcgcc ggcgccggcg gcatcaacgg ggccggcggg gccggcggca
3934141 acggcggcga cggcggggac ggcgcaaccg gtgccgcagg tctcggcgac aacggcgggg
3934201 tcggcggtga cggtggggcc ggtggcgccg ccggcaacgg cggcaacgcg ggcgtcggcc
3934261 tgacagccaa ggccggcgac ggcggcgccg cgggcaatgg cggcaacggg ggcgccggcg
3934321 gtgctggcgg ggccggcgac aacaatttca acggcggcca gggtggtgcc ggcggccaag
3934381 gcggccaagg cggcctgggc ggggcaagca ccacctcgat caacgccaac ggcggcgccg
3934441 gcggcaacgg cggcaccggc ggcaaaggcg gcgccggtgg tgcgggaacc ctgggcgtcg
3934501 gcggctccgg cggcaccggc ggggacggcg gcgatgcggg ctctggtggt ggcggcggct
3934561 tcggcggggc cgcgggtaag gccggcggcg gcggaaacgg cggtgttggc ggtgacggcg
3934621 gcgagggagc cagcggtctc ggcctgggcc tctccggctt tgacggcggc caaggcggcc
3934681 aaggcggggc cggcggcagc gccggcgccg gcggcatcaa cggggccggc ggggccggcg
3934741 gcaccggcgg ggccggtggt gacggcgccc cggcgaccct gatcggcgga cccgacggcg
3934801 gtgacggcgg ccaaggcggc atcggcgggg acggcggcaa cgccggattc ggcgccggtg
3934861 ttcccggcga cggcggggac ggcggcaacg ccggattcgg cgccggtgtt cccggcgacg
3934921 gcgggatcgg cggcaccggc ggggccgggg gcgccggcgg cgccggcgcc gacggggacc
3934981 ccagcattga cggcggccaa ggtggtgccg gcggccacgg cggccaaggc ggcaaaggcg
3935041 gcctgaacag caccgggcta gccagcgccg ccagcggtga cggcggcaac ggcggggccg
3935101 gcggggccgg cggcaacggc ggcgacggcg acggctttat cggcgggtcc ggcggcaccg
3935161 gcgggaccgg cggcgacgcc ggcgtcggcg gcctggccaa caccggcgga accgcgggca
3935221 acgccggtat cggcggggcc ggcggccgcg gcggcgacgg cggggccggc gacagcggcg
3935281 ccctctccca agacggcaac ggcttcgccg gcggccaagg cggccaaggc ggggtcggcg
3935341 gcaacgccgg cgccggcggc atcaacgggg ccggcggcac cggcggcacc ggcggggccg
3935401 gtggtgacgg ccagaacgga acgacaggcg tggcgagcga gggcggcgcc ggcggccaag
3935461 gcggtgacgg cggccaaggc ggcatcggcg gggccggcgg caacgccgga ttcggcgccg
3935521 gtgttcccgg cgacggcggg atcggcggca ccggcggggc cgggggcgcc ggcggcgccg
3935581 gcgccgacgg ggaccccagc attgacggcg gccaaggtgg tgccggcggc cacggcggcc
3935641 aaggcggcaa aggcggcctg aacagcaccg ggctagccag cgccgccagc ggtgacggcg
3935701 gcaacggcgg ggccggcggg gccggcggca acggcggcga cggcgacggc tttatcggcg
3935761 ggtccggcgg caccggcggg accggcggcg acgccggcgt cggcggcctg gccaacaccg
3935821 gcggaaccgc gggcaacgcc ggtatcggcg gggccggcgg ccgcggcggc gacggcgggg
3935881 ccggcgacag cggcgccctc tcccaagacg gcaacggctt cgccggcggc caaggcggcc
3935941 aaggcggggt cggcggcaac gccggcgccg gcggcatcaa cggggccggc ggcaccggcg
3936001 gcaccggcgg ggccggtggt gacggccaga acggaacgac aggcgtggcg agcgagggcg
3936061 gcgccggcgg ccaaggcggt gacggcggcc aaggcggcat cggcggggcc ggcggcaacg
3936121 ccggattcgg cgccggtgtt cccggcgacg gcgggatcgg cggcaccggc ggggccgggg
3936181 gcgccggcgg cgccggcgcc gacggggacc ccagcattga cggcggccaa ggtggtgccg
3936241 gcggccacgg cggccaaggc ggcaaaggcg gcctgaacag caccgggcta gccagcgccg
3936301 ccagcggtga cggcggcaac ggcggggccg gcggggccgg cggcaacggc ggagccggcg
3936361 ggctcggcgg gggcggtggc acaggcggca ccaacggcaa cggcggcctc ggcggaggcg
3936421 gcggcaacgg cggagccggc ggtgccgggg gaacgcccac cggcagtggc accgagggga
3936481 ccggcggcga cggtggagat gccggcgccg gcggcaacgg cggctctgcc accggcgtcg
3936541 gtaacggcgg taacggcggt gatggcggca acggcggcga cggcggcaac ggcgcacccg
3936601 gcggcttcgg tggcggcgct ggcgccggcg gcttgggcgg ctccggcgcc ggcggcggca
3936661 ccgacggcga cgacggcaac ggcggcagcc ccggcaccga cggcagctaa gctaacggca
3936721 gcccaaagcg ccagcagcca cccgacaacg ctgggcggct acccatggcc cgttggcagc
3936781 acaggctggc gatggccgtc cgaccgataa cacccgggcc atcgcatccc cagcacaacc
3936841 agctgtcctc gcgggcttat gcacgacggg ggagcactac cccacaagcg atggcaccac
3936901 tacatcgatc agatgcggcc cgggctcggc gaaggccgcg cgcagggcgt cggcgaattc
3936961 ctcgcaggtg gtgacacgac gtgcaggaac acccatacct tcggcgatct tgacgaaatc
3937021 cattgtggga cgcgatatat caaggagatc cagggccttc gggccaggat ccgaccccgc
3937081 gccgacacgt tgcagctcga tccgcagaat gtcgtaggcg ccgttgttgt agatgacggt
3937141 ggtgacgtcg aggttctccc gcgcttggct ccacaatcct gaaatcgtgt acattgccga
3937201 cccgtcggat tccaggcaca acaccgggcg gtcgggcgcg gcgaccgcgg caccgaccgc
3937261 agccgggatg ccgtaaccga ttgccccgcc ggtcagcgta agccagtcat gggccggggc
3937321 cccggcggtg gcctgcggca gcaggacacc acaagtattc gactcgtcga caacaatcgc
3937381 ccgttccggc agcaacgcac cgaccacatc ggccgccgac accgacgtca ggtcacccgt
3937441 cggcagctgc ggacgtgacg cgcccgccac cggggcaacc gtcccgggcg ctacctcgtc
3937501 ggccaacgcg gccagtgcgt cggccgcacc accgggttcg gcaagcacgt gcacctcaca
3937561 accggccggc accaggtcac tgggcatacc cgggtaggcg aaaaacgaca ccggcgacct
3937621 ggccccggcc agcacgagat gtttgacccc gtccagctgg gccgcggcac cttcagcgaa
3937681 ataggccagc cgttcgacgg cggggatacc ggcgccacgt tccaggcacg tcggaaacgt
3937741 ctcgcataac caacgggccc cggttgcctg cacgatccgc gcagccgcgg tcagccccgg
3937801 cccgcgggtg gcatccccac cgatcagcat catggcgggt tcccctgagc gcagcacccc
3937861 agccaccggc cccacgtcca ctggcgccgc cgccgcctga gccggcacgc ccgcggccgc
3937921 gtgggcaccg tcgctccaac acacatccgc gggcagaatc agcgtcgcga tctgtgaacc
3937981 tgaccggctg gccgcaatgg ccgcttcagc gtcggccccg acgtcggcgg cagcctccgt
3938041 ccggcgcacc catcccgaaa cggtgccagc gaccgcatcg atatcggatt ccagcggggc
3938101 gtcgtacttc ttgtggtaag tcgcgtggtc tccgacaacc accaccatcg gcacccgggc
3938161 acggcgcgcg ttgtgcaggt tggccaggcc gttgcccagt ccggggccca gatgcagcag
3938221 caccgccgcc ggccggccag caatgcgggc ataaccgtcg gcggccccgg tagccacgcc
3938281 ttcgaacagg gtcagcatgc cacgcatgcg cgggacggcg tctagcgccg ccacgaaatg
3938341 catttccgac gtgccagggt tggcgaagca cacatcgaca cccccgtcga ccagggtgtt
3938401 gatcagggcc tgagcaccgt tcacgtctgc acctttcctc gtgggtccag cttgaatacc
3938461 cgcacagcgt tgccgtgcag aaagtcgcga cgagcttcgt cgcttagccc cagttcgtca
3938521 agaccggtca gggcgtgcgt gtgggcgatc atcgggtaat tggtaccaaa cagcaccttg
3938581 cgctgtcccg tgtcggtttt catgaaccgc accagcttcc cgggcagccg cttgatggtg
3938641 taggccgagg tgtcgatgta gacattctcg tgtttgcggg cgaccgcgac catctcctcg
3938701 gtccacggat agccgacatg tccgcacacg atcaccagtt ccggaaagtc caacgccacc
3938761 tggtcgatgt agggaatggg gcgtccggtc tccgacggcc gcagcgggcc ggtgtgacca
3938821 acctgggtgc agaacggcac cgcggactgc acgcattcgg cgaacaacgg atagtagcgg
3938881 cggtcggtcg gcggggcgcc ccatagccaa ggcaccaccc gcaggccgac gaacccctca
3938941 ccgactcggc gcctcaactc ccggacggcc gccatcgggc gatccaggtc gaccgccgcc
3939001 agaccggcaa aacggttggg gtacaaccgg acccattccg caacagcgtc attagagatg
3939061 aggtcctggc cgttggggcc acgccaggcg ctgagcaaac ccagggtgac gccgccggcg
3939121 tccatcgagg agacggtcgc ttcgatcggg atgtcggtct ccgggataga cccaccggtc
3939181 caccggcgca gcgaggcgaa catatcgccg tgtaggaacc gttgcgtcgg atgctgcatc
3939241 cacacatcga tggtcatcgc gtttcagact gtagccgccc gggcggcgac tacccgcggc
3939301 gacgctgcag atcatcgccc ggccagggtg ctaccaggtt gctgccatcc ccgaatgttc
3939361 gcggtcggag ggcgacgcga cgtgttgaaa cgccgtacgt tcgggccttc ccgcgagaag
3939421 ccctagccgc ccgagattgt ccctcccggc gttcgtggcc acgcggtgct tcgccttttt
3939481 gcccatccca aattacacgg gtggtactca cgagaaagct tggacgtatt gggcgggtgc
3939541 tgaattatga tcccgacaca actgcatcaa tttagccgcg tcgtgatgct atccgccgac
3939601 ggtttggagc tggtccgtgt cgttcgtgtt gatctcaccc gaagttgtgt ccgccgccgc
3939661 cggggatcta gcgaacgtgg gatcgacaat cagcgccgcc aacaaggcgg cagcggctgc
3939721 gaccacgcag gtgctggccg cgggcgccga tgaggtgtca gcgcgcatcg cggcgctgtt
3939781 tggtatgtac ggcctggaat atcaggcgat cagtgcgcaa gttgccgcgt atcaccagca
3939841 gttcgtgcag acgttgcgca ccggagcggc ctcgtacatg ttggccgagg ccaccaacgt
3939901 cgagcaaaat ctactgaacc tcatcaacgc gccgacccag acgctgctcg ggcgcccgct
3939961 gatcggagac ggggccaacg cgacgacgcc gggcggggcc ggcggagacg gcgggctgct
3940021 gtttggcagc ggcggcaacg gcgcgcccgg tgcacccggc caggctggcg gtgccggtgg
3940081 gtctgccggg ctactgggca acggcgggag cggcggagcc ggcgggacgg gcgcgcccgg
3940141 cggaaacggc ggcaatgccg gttggctata cggccgcggc ggagtcggcg gcgccggggg
3940201 aatcggcggc ggaacaggcg gggccggcgg gcacgcgtgg ctgttcggcc acgggggaac
3940261 cggcggtatc ggtggcgggc ccggcggcaa cggcgggtgg ctgctcggca acggcggaca
3940321 tggcggcgct ggcggaatcg gtggcggcag cggcggcgct ggcgggaacg gcgggtggct
3940381 gctcggcaac ggcggtatcg gcggagcggg cggaaccggc ggcggagcgg gcggcaccgg
3940441 tggcaacgcc gcgtggctgc tcggcggtgg tggtaccggc ggcgccggcg gaatcggtgg
3940501 tggcaacggc gggcacggcg gcaacggcgg gtggctgctc ggcaacggcg gcaacggcgg
3940561 cctcggcggt gacggtgacg gcggtactgg cggcggccac ggcggcaacg gcgggaatcc
3940621 cgggtggctc ttgggcacag ccgggggtgg cggcaacggt ggcgccggca gcaccggtac
3940681 tgcaggtggc ggctctgggg gcaccggcgg cgacggcggg accggcgggc gtggcggcct
3940741 gttaatgggc gccggcgccg gcgggcacgg tggcactggc ggcgcgggcg gtgccggtgt
3940801 caacggtggc ggcgccggcg gggccggcgg ggccggcggc aacggcggcg ccgggggtca
3940861 agccgccctg ctgttcgggc gcggcggcac cggcggagcc ggcggctacg gcggcgatgg
3940921 cggtggcggc ggtgacggct tcgacggcac gatggccggc ctgggtggta ccggtggcag
3940981 cggcggcacc ggcggtgacg gcggcgcccc cggcaacggt ggcgccgggg gtgccggcca
3941041 gttgttgagc catagcggcg tggccggtgc tagcggcaaa ggtggtgccg gcggcaccgg
3941101 cggcaacggc ggggccggca gtgccggcgc cgacgccccc gcaggctccg gcgcgatggg
3941161 tagcactggc tttgctggcg gcgccggcgg tgacggcggt aacggcggcg ggagcggtgc
3941221 cagccaaggc aacggcggca acggcggcaa cggcggcacc ggcggcaaag gcggcaccgg
3941281 cggggccggc atgaacagcc tcgacccgct gctagccgcc caagacggcg gccaaggcgg
3941341 caccggcggc accggcggca acgccggcgc cggcggcacc ggcttcaccc aaggcgccga
3941401 cggcaacgcc ggcaacggcg gtgacggcgg ggtcggcggc aacggcggaa acggcgcaga
3941461 caacaccacc accgccgccg ccggcaccac aggcggggcc ggcggggccg gcggggccgg
3941521 cggaaccggc ggagccgccg gcaccggcac cggcggccaa caaggcaacg gcggcaacgg
3941581 cggcaacggc ggcaccggcg gcaaaggcgg caccggcggg gccggcatga acagcctcga
3941641 cccgctgcta gccgcccaag acggcggcca aggcggcacc ggcggcaccg gcggcaacgc
3941701 cggcgccggc ggcaccggct tcaccccaag gcgccgacgg caacgccggc aacggcggtg
3941761 acggcggggt cggcggcaac ggcggaaacg gcgcagacaa caccaccacc gccgccgccg
3941821 gcaccacagg cggggccggc ggggccggcg gggccggcgg aaccggcgga accggcggag
3941881 ccgccggcac cggcaccggc ggccaacaag gcaacggcgg caacggcggc aacggcggca
3941941 ccggcggcaa aggcggcacc ggcggcgacg gtgcactcgc aggcagcagc ggtggtgccg
3942001 gcggtaaagg cggcaacggc ggcgacgccg gcaaggccgg taccggctcc gctcctggca
3942061 cggcggggac cggcggcgat gggggtaagg gcggcaacgg cggcattggc gctgccggca
3942121 caaccggccc cgtaggcacc ggcgcgtccg gcggcaccgg tggtagtggt ggcgccggcg
3942181 gaaccggcgg tgacggcggc gccgccaacg gcggcaccgc cggggctggc ggggcgggcg
3942241 gcaatggcgg caaaggcggc gacggtggag caggcgtcac cagcagcacc gccggcaaca
3942301 gcggcggcgc gggcggcagc ggcggaaagg gcggagacgc gggcgcgggc ggcgccggtg
3942361 ccactccggg cgccaacggt atcgctggca atggcggcga cggcggagat ggcgcggctg
3942421 gtgccgtcgg catctccggc gcaaccggcg ctggcgacgg cgggcatggc ggaaccggcg
3942481 cggccggcgg caacggtgga accggcggtg ctggcggtag cggcatcgac ggcgtcggcg
3942541 gcgggaccgg aggtaccggc ggcaacggcg gcaacggcgc catcggcggc gctggcggag
3942601 acgccggtgg tagcggaaat agcggcggaa acggtgggat tggcggaaag ggcggaaacg
3942661 ccggtgccgg tggtgccgcg ggcagcaacg gcggtaccgt cggcgccaac ggtaccggcg
3942721 gcgacggcgg caacggcggc gctgccgggg ccgccacggc tggcagcaac ggtggggccg
3942781 gcaccggctc ggccggcggc aacggcggca ccggcggcag aggcggcagt ggtggcgccg
3942841 gcggcgacgg tatcggtggc gtcggcggcg gcaagggcgg caacggcgcg gacggcgaag
3942901 tcggcggtgc gggcggcgcc ggcggcagcg ggcccaacac cagtcccggc ggcaacggcg
3942961 ggcaaggagg tcaaggcggc agcggtggtg ccggtggggc ggccggggct ggcggcgccg
3943021 gtggcggcgc taacggcacc gctggcaacg gcggccaagg cggtgccggc ggcaccggcg
3943081 gcgccggcgc agcctcctca gctaccaacg gcggcagcgg cggcgccggc ggcaccggag
3943141 gcgacggcgg cagcggcggc gccggcggca ccggaggcgc cggcggcacc ggcggggcgg
3943201 ccggcgacgg cggacaaggt ggccagggcg gcgccggcgg cggtgccggt ggtcaaggtg
3943261 gtgccggcgg tgccggcggg accggcggca acggcggcaa tatcaccggc ggcaccgcgg
3943321 gcaccgcggg ggccgccggt aacggcggcg ccgccggaaa gggtggcgcc ggcggccaag
3943381 gcggcaccgg tggcgggacc gggggtcagg gtggcgccgg cggcgacggc ggtgccggcg
3943441 gcaccggcgg cgaccgcacc gtcggcggtg gcacggtccc cgccggctcc ggtggacaag
3943501 gcggtaacgc tggcggtggt ggggccggcg ggcagggtgg agccgacggc ggcagcggcg
3943561 gcgacggcgg cgacgccggc acaggtggca atggcggtaa cggcggcaac cgtaattccg
3943621 gcaatggcac cggcggcgct ggcggcaacg gtggtggtgg tgctaacggt ggcgccggcg
3943681 gcgctggggg cagcggcggc ggcaccggcg gcaacggcgg cgctggcggc gacgccggcg
3943741 acgccggcaa cggcggcaac ggcaacggca ccggcaacgg cggcaacggc ggcaacggcg
3943801 gcatcgccgg catgggcggc aacggcggtg ccgggacggg cagcggcaac ggcggcaacg
3943861 gcggcagcgg cggcaacggc ggcaacgccg gcatgggcgg caacagcggc accggcagcg
3943921 gcgacggcgg tgccggcggg aacggcggcg cggcgggcac gggcggcacc ggcggcgacg
3943981 gcggcctcac cggtactggc ggcaccggcg gcagcggtgg caccggcggt gacggcggta
3944041 acggcggcaa cggagcagat aacaccgcaa acatgactgc gcaggcgggc ggtgacggtg
3944101 gcaacggcgg cgacggtggc ttcggcggcg gggccggggc cggcggcggt ggcttgaccg
3944161 ctggcgccaa cggcaccggc gggcaaggcg gcgccggcgg cgatggcggc aacggggcca
3944221 tcggcggcca cggcccactc actgacgacc ccggcggcaa cgggggcacc ggcggcaacg
3944281 gcggcaccgg cggcaccggc ggcgcgggca tcggcagcct tggcggcggc actggcggcg
3944341 atggcggcaa cggcggcaac ggcggtaccg gcggcgaggg cggcgaggtc ggcggcgccg
3944401 gcggcaccgg cggtgcggcc ggcaatggcg gcgatggcgg caccggcggc accggcggcg
3944461 gggacggggg cgccggcggc accggcggca ccggcggcac cggcggcctc ggcgaccccc
3944521 gggtcggcgg atccggcggc gacggcggca ccggcggcag cggcggtgcg gccggcaatg
3944581 gcggcaacgg cggcaacgcc ggcgcgggag gcaatggcaa cggcggcacc ggtggggccg
3944641 gcggtatcgg cggcaccggc ggcaatggcg gcgacgccga gcccggagtg cccccgggag
3944701 ccggtggtgc tggcggcgcc ggcaccaccg gcggcaaggg tggcaccggc ggcaacggca
3944761 gtggcaccgg ctcgggcggc accggcggcg atggcggcac cggcggtggt ggtgggaacg
3944821 gcggcaccgg ctggaatggc ggcaagggag acaccggcag cggcggtggc gccggagacg
3944881 gtggtaaggc accagccggt ggcaccggcg gcgccggcgg cgacggcgga gcgggcggca
3944941 agggcggcag cggcggcgtc tagtcgcgat gggcccagcg gccgcgatgg tgcgccgggc
3945001 gtccgccggc gagtggtcca gccagatttg acgacaaacg gcgacccagc ggtatccccc
3945061 agccgcggcg ccatagccgc gacccgcgca atcaggaacc gctcgtcacg tgtcccgcat
3945121 gcacgtcatc ggctggccgc gcctcggtct gctccttggc ccagcggtag tccggcttac
3945181 cggcgggcga acgcttcacc tcgtcgacaa accacagact gcgcggcact ttgtagcccg
3945241 cgatctcgga gcgcacgaac gagtccaact cggccaacga cggccgacaa cccggccggg
3945301 cctgcaccac ggcggccacc tgctggccgt aacgcggatc gggcaccccg accaccagag
3945361 cgtcgaacac gtcgggatgc cccttcaaag cggcctcgac ctcttcgggg tagaccttct
3945421 cgccgccgct gttgatcgac accgagccac gacccagcat ggtgaccgtg ccgtcctcct
3945481 cgacttgggc gtagtccccc ggaatggcgt agcgcacacc gttaatcgtc cggaacgtct
3945541 cggccgtctt cttctcgtcc ttgtagtagc cgacgggaat gttgcccttc ttggcgagcg
3945601 tgcgcgcggg tcgcactgct tggcgcctgg tgcaccggtc gccgggcggc tcctccccag
3945661 ggcgctccag gttcgttgcg gcattaccag aaagccggca catattagat gagtggcaac
3945721 taaggttctc acttaaagat gccgccatat cggccgtggt tgcaccggcg caaagatggt
3945781 tgggagttcg cccatgtcgt tcgtgttgat cgcaccggaa ttcgtgacag cagccgcggg
3945841 ggatctgacg aatctgggtt cgtcgattag cgcggccaac gcgtcggcag ccagtgcgac
3945901 cacgcaggtg ctggctgcgg gcgccgatga ggtgtctgcc cgtattgcgg cgctgttcgg
3945961 cgggtttggc ctggagtacc aggcgattag tgcgcaggtg gcggcctacc accagcggtt
3946021 tgtgcaggcc ttgagtaccg gcgcgggcgc atatgcctcg gccgaggccg ccgccgctga
3946081 gcagatcgtg ctgggcgtga tcaatgcgcc cacccaggcg ctgctggggc gcccgttgat
3946141 cggtgacggc gccaatgcga cgactcccgg cggggccggc ggggccggcg gtctgctgtt
3946201 cggcaacggc ggggccgggg cagccggggc gcccggccag gccggcgggc ctggcgggcc
3946261 cgccggattg tggggcaacg gcgggcccgg cggggccggc ggcagcggtg ggggcaccgg
3946321 cggtgccggc ggcgccggtg ggtggctgtt cggggttggc ggcgccggcg gtgtcggtgg
3946381 ggccggtggc ggcaccggcg gggcgggtgg gcccggtggt ttgatctggg gcggcggcgg
3946441 ggccggcggt gtcggtgggg ccggtggcgg caccggcggg gccggcggcc gcgccgagct
3946501 gctgttcggc gccggcggtg cgggtggggc gggcaccgac ggcgggcccg gtgctaccgg
3946561 cgggaccggc ggacacggcg gagtcggcgg cgacggcgga tggctggcac ccggcggggc
3946621 cggcggggcc ggcgggcaag gcggggcagg tggtgccggc agcgatggtg gcgcgttggg
3946681 tggtaccggc gggacgggcg gtaccggcgg cgccggtggc gccggcggtc gcggcgcact
3946741 gctgctgggc gctggcggac agggcggcct cggcggcgcc ggcggacaag gcggcaccgg
3946801 cggggccggc ggagatggcg ttctgggggg tgtcggtggc actggtggta agggcggtgt
3946861 cggcggcgtg gctggcctcg gcggggccgg tggtgccgcg ggccagctct tcagcgccag
3946921 cggagcggcc ggtaacgccg gtgtcggcgg ggccggcggc caaggcggtg acggcggagc
3946981 cggcggggcc ggcgccgacg ccgaccagcc cggcgccacc ggcggcaccg ggttcgccgg
3947041 tggagccggc ggagccggcg gggccggcgg tagcagcggt gccggcggca ccaacggctc
3947101 cggcggcgcc ggcggacaag gcggcgccgg gggtgctggc ggggccggcg ccgataaccc
3947161 caccggcatc ggcggcaccg gcggtgacgg cggcaccggc ggagccgccg gagccggcgg
3947221 ggccggcgga gcggccggca ccggaggcac cggcggcatg atcggcacca caggcaacgc
3947281 cggtgtcggc ggggccggcg gccaaggcgg tgacggcgga gccggcgggg ccggcgccga
3947341 cgccgaccag cccggcgcca ccggcggcac cgggttcgcc ggtggagccg gcggggccgg
3947401 cggggccggc ggtagcagcg gtgccggcgg caccaacggc tccggcggcg ccggcggcac
3947461 cggcggacaa ggcggcgccg ggggtgctgg cggggccggc gccgataacc ccaccggcat
3947521 cggcggcacc ggcggtgacg gcggcaccgg cggagcggcc ggagccggcg gggccggcgg
3947581 agcggccggc accggaggca ccggcggcat gatcggcacc acaggcaacg ccggtgtcgg
3947641 cggggccggc ggccaaggcg gtgacggcgg agccggcggg gccggcgccg acgccgacca
3947701 gcccggcgcc accggcggca ccgggttcgc cggtggagcc ggcggggccg gcaaggccgg
3947761 cggtagcagc agtgccggcg gcaccaacag ctccggcagc gccggcggca ccggcagaca
3947821 aagcggcacc gggggtgctg gcggggccgg cgccgataac cccaccggca tcggcggcac
3947881 cggcggtgac ggcggcaccg gcggagcggc cggagccggc ggggccggcg gagcggccgg
3947941 caccggaggc accggcggca tgatcggcac cacaggcaac gccggtgtcg gcggggccgg
3948001 cggtagcagc ggtgccggcg gcaccaacgg ctccggcggc gccggcggca ccgacggaca
3948061 aggcggcgcc gggggtgctg gcggggccgg cgccgataac cccaccggca tcggcggcac
3948121 cggcggtgac ggcggcaccg gcggagcggc cggagccggc ggggccggcg gagcggccgg
3948181 caccggaggc accggcggca tgatcggcac cacaggcaac gccggtgtcg gcggggccgg
3948241 cggccaaggc ggtgacggcg gagccggcgg ggccggcgcc gacgccgacc agcccggcgc
3948301 caccggcggc accgggttcg ccggtggagc cggcggggcc ggcgggtccg gcggtagcag
3948361 ctgtgccggc ggcaccaacg gctccggcgg cgccggcggc acctgcggac aagtcgtcgc
3948421 cgggggtgct ggcatcagct tcagcaacgg cagcaacggc ggcaccggcg gcaccggggg
3948481 cgtgggcggc accgggggcg acggcggcaa cgcaggcacc ggcgccggcg accccggcaa
3948541 aggcggcacc ggcggcaccg gcggcaccgg cggcagcggc ggggccggcg gtagcggcgg
3948601 ggccaacttc aacggcggca ccggcggcac cggcggcacc ggcggcaaag gcggcctaaa
3948661 caccgacgga ctcagcagcg ccaccagcgg caccggcggc accggcggca ccggcggcaa
3948721 aggcggcacc ggcggggccg gcgacgactc cgccggcggg accggcggca caggcggggc
3948781 cggcggcaac gccggcgccg gcggcctagc caacaccggc ggcaccgcag gcaacgcggg
3948841 catcggcggt gacggcggcc aaggcggtaa cggcggccaa ggagacagcg gttccggatt
3948901 gggcggccag cccggctttg ccggcggggc cggcggcaaa ggcggggccg gcggtagcag
3948961 cggtgccggc ggcaccaacg gctccggcgg cgccggcggg gccggcggac aaggcggcgc
3949021 cgggggtgct ggcatcagct tcagcaacgg cagcaacggc ggcaccggcg gcaccggggg
3949081 cgtgggcggc accgggggcg acggcggcaa cgcaggcacc ggcgccggcg accccggcaa
3949141 aggcggcacc ggcggcaccg gcggcaccgg cggcagcggc ggggccggcg gtagcggcgg
3949201 ggccaacttc aacggcggca ccggcggcac cggcggcacc ggcggcaccg gcggcaaagg
3949261 cggcatgggc ggcatcgctg gcgacggcgg gcccggcggt gacggcggca acgccggggt
3949321 cggaggaaaa ggcggcacca acggcaacgg cggcagcggc gggaccggcg gcacaggcgg
3949381 ggccggcggc aacgccggcg ccggcggcct agccaacacc ggcggcaccg caggcaacgc
3949441 gggcatcggc ggtgacggcg gccaaggcgg taacggcggc caaggagaca gcggttccgg
3949501 attgggcggc cagcccggct ttgccggcgg ccccggcggc aaaggcgggg ccggcggcaa
3949561 cgccggcacc ggcggcacca acggctccgg cgccggcggg gccggcggac aaggcggcgc
3949621 cgggggtgct ggcatcagct tcagcaacgg cagcaacggc ggcaccggcg gcaccggggg
3949681 cgtgggcggc accgggggcg acggcggcaa cgcaggcacc ggcgccggcg accccggcaa
3949741 aggcggcacc ggcggcaccg gcggcaccgg cggcagcggc ggggccggcg gtagcggcgg
3949801 ggccaacttc aacggcggca ccggcggcac cggcggcacc ggcggcaccg gcggcaaagg
3949861 cggcatgggc ggcatcgctg gcgacggcgg gcccggcggt gacggcggca acgccggggt
3949921 cggaggaaaa ggcggcacca acggcaacgg cggcagcggc gggaccggcg gcacaggcgg
3949981 gcccggcggc agcggcggcg cgcccaccgg cagcggcacc ggcggcaaag gcggcgccgg
3950041 cggtgacggc ggcgatggcg ccgacggagg ggcagccacc ggcgtcggcg acggcggcga
3950101 cggtggtaac ggtggtaacg gtggtaacgg cggcacgggc gtcggctcgc ccggcggcct
3950161 cggcggggca ggaggcactg gaggcctcgg cggcgccggt gcaggcggcg gagccgacgg
3950221 cgatgatggc gacgacggcc aacccggcaa caacggcagc tgaagcacca cctgccacca
3950281 gacaacgccg tcgatgtggc gctccggcgt gcgcaaggca aatcggtgcg atcctgacca
3950341 gccaggtgat tacctggttc gactcatgcc gagcgaccgt cccagcgccg cagtggatgc
3950401 atacacggta ggttcgacgg acaccctggg ctggctgacc gaatggccgc cgcagctccc
3950461 cgaccgaacc gtcagcggca acatgtcacc tgcatcgtcg ccaagcccag gcgatcgccc
3950521 ggccccgcaa gcggatgtgt tctcctgccc tccgtgggca gcgcgcccga cacccgtaag
3950581 cggatgtccc cgacggactc cggccggcct agccgatggc taccccaggg agtgccgcac
3950641 gatggccgtc gatcaagtgc ggtccggctt cggcgaaccc tccgcagcta tttcgcgacg
3950701 cgcgagaaca cccgtgcctt acttccatcc acatcgatgt cggctcggcc cccgagaggc
3950761 acgacagccg acccatgtcg accttccgtg cggggtgtcc ggagccggtc gcagccgcac
3950821 ccatcaccca ccgctcgtca cgtgtcccgc atgcacgtca tcggctggcc gcgcctcggt
3950881 ctgctccttg gcccagcggt agtccggctt accggcgggc gaacgcttca cctcgtcgac
3950941 aaaccacaga ctgcgcggca ctttgtagcc cgcgatctcg gagcgcacga acgagtccaa
3951001 ctcggccaac gacggccgac aacccggccg ggcctgcacc acggcggcca cctgctggcc
3951061 gtaacgcgga tcgggcaccc cgaccaccag agcgtcgaac acgtcgggat gccccttcaa
3951121 agcggcctcg acctcttcgg ggtagacctt ctcgccgccg ctgttgatcg acaccgagcc
3951181 acgacccagc atggtgaccg tgccgtcctc ctcgacttgg gcgtagtccc ccggaatggc
3951241 gtagcgcaca ccgttaatcg tccggaacgt ctcggccgtc ttcttctcgt ccttgtagta
3951301 gccgacggga atgttgccct tcttggcgat gacgccccgc atccccgagc cgggcttgac
3951361 ttcgttgccg tcgtcatcga gcacgacggt gcgatggtcg atccgcaccc ggggcccgcc
3951421 gccatgcgcc tgcccggcag caacgacgct ggtaccgcca aaacccgtct ccgacgagcc
3951481 aattgagtcc gtgatcaccc gattcggcag cagctcaagg agtttctcct tgatgctcgg
3951541 cgagaacagc gccgcggtgc tggccaacag gaacaacgac gacaggtcgt agtcgttgcc
3951601 cttgaccagc gcgtcgacca gcgggcgggc catcgcatca ccggtgaaga acagcaggtt
3951661 caccttgtgt ttgtggatcg tgcgccacac ctcgtcggcg ttgaattccg gtgccagtac
3951721 cgtggtttgg cccgagaaga gcgccatcca ggtggccgac tgggtggcgc cgtggatcat
3951781 cggcgggatc gggtagcgga tcatcggtgg attcgccgcg gccgccttgg ccaggtcgta
3951841 ttcgtctttg acgaactctc ctgtcgcaaa gtcggttcca ccgaacagca cacgatagat
3951901 gtcctcgtga cgccacatca cacccttggg gaaaccggtg gtgccgccgg tgtagagcag
3951961 atagatggcg tcggcgctgc gttcgccgaa gtcacgctcc ggcgagcccg ccgcgatcgc
3952021 ggaatagaac tcgacgccgc cgtagcgccg atagtcctgg tccgagccgt cctcgacgac
3952081 caagatcgtc cttacatggg gcgtgtcggg gagaacgttg gcgacccggt cggcgtagcg
3952141 gcgttcgtgc accaacgcga ccatgtcgga gttgtcgaac aggtagcgaa gttcgccctc
3952201 cacgtaacgg aagttgacgt tcaccaagat ggcgcccgcc ttcacgatgc ccagcatcgc
3952261 gatcacgatc tcgatgcggt tgcggcagta caggccgacc ttgtcgtcct tttgcacgcc
3952321 ttgatcgatc aggtggtgcg cgaggcggtt ggccttatcc tccagctggg cgtaggtcaa
3952381 ctgctcatcg ccgcagataa cggcgacacg gtcaggcacg gcgtcgatgg cgtgctcggc
3952441 gagatcggca atattcaggg ccacggccac caaactagaa cgtgttacat ttcttgacaa
3952501 gctcacaccc gacgggcaga aagaggtggc ggccgtggca accgtggaat ccggacccga
3952561 cgcgctggtg gagcggcgcg gccacaccct gatcgtgacc atgaaccggc cggccgcccg
3952621 caacgcgctg agcaccgaaa tgatgcgaat catggtgcag gcctgggatc gcgtcgacaa
3952681 cgatcccgac atccgttgct gcatcctcac cggagccggt ggctactttt gcgccggcat
3952741 ggacctcaag gcggcaaccc agaaaccgcc gggcgactct ttcaaggacg gcagctacgg
3952801 cccgtcgcgc atcgatgccc tgctcaaagg gcgccgcttg accaaaccgc tgatcgccgc
3952861 cgtcgagggg cccgcgatcg ccggcggcac cgagatcctg cagggcaccg acatccgggt
3952921 cgccggtgaa agtgcgaagt tcggcatctc cgaggccaag tggagcctgt acccgatggg
3952981 cggctcggcc gtgcggctgg tccggcagat cccctacact ctggcctgcg acctgctgct
3953041 gaccggacgg cacattaccg ccgccgaggc caaggaaatg ggcctgatcg gccacgtggt
3953101 gcccgacggc caggcgctga ccaaggctct agaacttgcc gacgccatct cggctaacgg
3953161 acccctggcc gtgcaggcca tcctgcggtc catccgcgag accgagtgca tgcccgaaaa
3953221 cgaggcgttc aagatcgaca cccagatcgg catcaaggtc ttcctgtccg acgacgccaa
3953281 ggaaggcccg cgcgcgttcg ccgagaagcg cgcacccaac ttccagaacc gctaggcgcc
3953341 gagcgtgaac tgagggcgag atttcggccg attttccgcc ctcagttcac gttggacggc
3953401 ggtgtcggtg cacgacggca cactgcgatc gtgatcgaac cattcctcgg cagcgaagcg
3953461 attgcctccg gcgcgttgac gcggcaccgg ctgcgaagcg catacgccac gatccacccc
3953521 gacgtctatg tctcccccgg cgccgacctg accgcatgga gtcgcgctca ggccgcctgg
3953581 ctatggtcgc ggcggcgcgg cgtcatcgcc gggcagtcgg cggcggcgat gcacggcgcc
3953641 aaatgggtcg acgcgcgaca ggcggccgag ctgctctacg accaccgtcg cccgccggcc
3953701 ggcatccaca cctggtcgga ccgtgtcgcc gacgacgaga tccagccaat ctccggcatg
3953761 aatacgacca caccggcgcg caccgccctc gacctcgccc gccgctatcc ggtcggcaag
3953821 gccgtcgcgg ccatcgatgc gctcgcccgc gcgacggacc tcaagctggc cgatgtcgag
3953881 atgctcgccg aacgctaccg gggaagccgc ggcatccgaa atgctcgtat cgcattggat
3953941 ctggtggatc caggtgccga gtcacctcgc gagacgtggc tgcgtctgct actcatccga
3954001 gcgggctttc caagaccaca gacccagatc ccggtttacg acgagtacgg ccagctggtc
3954061 gcggttatcg atatgggttg ggcaggaatc aaggtcggcg tggattacga gggcgaccat
3954121 caccggaccg accgcagaac gttcaacaag gacatcaagc gtgccgaagc gttgaccgag
3954181 cttgggtgga ccgacgtacg cgtgacggtc gaggacaccg agggtggcat catctggcgg
3954241 gtgtcagcgg cctggcagcg ccgaacgtga actcacggcg gagattcggc cgatattccg
3954301 ccctcagttc acgttcggcg tggctcagcc cagcggcggg ctcggcgtga acaccaccgg
3954361 catggattcc aggccgctga caaagttcgc cggccgcagc ggcaacacgg agtcatcggc
3954421 gaccaaccgc aggtcgggta gccgccgcaa cacccgttcc gtcatcaacg acagctccaa
3954481 ccgggccagc tgattgccca ggcagaaatg cgtgccgaag ccaaacgcca agtggctgtt
3954541 tggatttcgc tgaacatcaa acttttccgg ttcacagaaa accgcctcgt cgaagttcgc
3954601 cgactcgaag agcagcatca tcttctcgcc ggcacacaac gccgtgccgt gaaactcggt
3954661 atccgcggtc aacacccggc acatgttctt taccggggcg gtccaacgta gcatctcctc
3954721 gatggccccg ggcagcaacg acgggtcgcg ctgcagcagg tcccactggt cacggttgcg
3954781 cagcagctgc tcggtaccac cgctcaaggt atgccgcgtg gtctcgtcgc cgccgatcag
3954841 gatcagcagc gtctccatga ccagctcgtc gtcgcttagc cgctcgccgt caacttcgga
3954901 actcaccagc acgctgacca ggtcgtcggt ggggtccgct cgccgtgccg caatggtggc
3954961 ccgggtgaag tcgttgtagg ccgcgaaggc gtccatggtg atctggaaat cctcttgaga
3955021 cacatgcgaa ctgaggaatg tcaccagatc gtcggaccac cgcaagaaca tgtcccgctg
3955081 ctctggacgc accccgagca tgtcgccgat caccgccatc ggtagcggcg cggccaggtc
3955141 ccgcacgaag tcacactcgc cgcgttcgca cacggcgtcg atcagggtgt cacacagcgc
3955201 ggcaatcgac gcctccttgt ccttcacccg cttgcgggtg aagccggcgt taaccagctt
3955261 gcgccgcaac agatgtgcgg gatcgtccat gtcgatcatc atcggcaggg cgggctggtc
3955321 ggggcggatg ccgccggcgt tggagaacag ctcgggttga cgttcggcgt cgatcaccgc
3955381 ctggtacgtc gacgcggccg ccaggccgtt gcgatcgcgg aacaccggtt ggttggcccg
3955441 catccaccgg tacgcggccc gcgcctcgcg gctggcgtag aagttgccgt cggccagatc
3955501 cacgtccgga gcttcagtca tcgcgatcct ccgcactaca gtgggcgata tgcccgtctc
3955561 gcaacacacc atcgccggca cggtgctcac catgccggtg cgcattcgca ccgccaacct
3955621 gcattccgcg atgttctcgg tgcccgccga cccagcgcag cgcctcatcg actacagcgg
3955681 gctgcgggtg tgcgaatacc tgcccggtaa ggcaatcgtg atgcagatgc tggtgcgcta
3955741 cgtcgacggg gatttggggc gataccacga gtacggcacc gcgatcatgg tgaacccgcc
3955801 cggcacccaa cgccgcgggc ccagagccct cacccgagcc gccgcgttca tccatcatct
3955861 gccggtagat caggtgttca cgcttgaggc cgggcgcacc atctggggct tcccgaagat
3955921 catggcggac ttcaacgtca ccgacggccg gaggttcggc ttcgacgtca gcgccgacgg
3955981 acggttgatc gccgggatcg agttcagcac cggcctgccg gtgccgaccc tcgggtggca
3956041 aatgttgaag acctactccc accatgacgg cgtaactcgc gagattccct gggaaatgaa
3956101 agtctcgggc ctgcgcgccc ggctcggcgg cgcccgactg cggttgggag accatcccta
3956161 cgccaaagaa ctggcatcgc tgggcctgcc gaagcgggct ctgttgtccc agtcggcggc
3956221 caacgtagaa atgaccttcg gcgacggtca cccgatctga accgcaagaa agcgaagcca
3956281 tcagcccaat ctagaacgcg ttctagcccg ctggcaagga tcgatcagac cagggcggca
3956341 aggtcgcgga cctgctctgc gctgccggcg gtcaccacca tcatggtgac cccggcggcc
3956401 tcccagacgg ccatctgctt acgcacgtgg tcgatgtcac cgacgatcac ggcgtcgtcg
3956461 acgagctcgt ccgggatgat ctcggcggcc tcgtccttgc ggccagaccg aaataacttg
3956521 gtgacctcat cgaccacttg cgtgtacccc atccggcgat agacgtcggc gtggaagttg
3956581 gtctcttcgg cgcccatccc gcccatgtag agcgccagga acggcttgat tccggcaaac
3956641 gcggccgccc gatcgtcggt gatgaccacc tgcgccgtcg cgcagatctc gaagtcctcg
3956701 cggctacgcc gggcgccggg ccgggcgaat ccttcgtcga gccattcgtt gtacatgccg
3956761 gccatgcgtg gcgaatagaa gatgggcagc cagccatcgc agatctcggc ggccagcgcg
3956821 acgttcttgg gcccctcggc ccccagcatg attggtatgt cggcgcgcag cggatgggtg
3956881 atgggtttga gcgctttgcc cagacctgtc gtgccctccc ccgtcagtgg cagccggtag
3956941 tgcggcccgg cgctggtcac cggcgattct cgggcccaca cctggcgcac gatgtcgatg
3957001 tattcgcggg tgcgagccag cggcttggga aaccgctgcc cgtaccaacc ctcgaccacc
3957061 tgcggaccgg acacgccgag cccgagaatg tgccggccac cggacagatg gtccagtgtc
3957121 agcgcggcca tcgcacaggc cgttggtgtg cgcgcggaca gctggatcac cgacgtaccc
3957181 agccgcaccc gttgcgtcga cgagccccac caggccagcg gcgtgtaggc gtcggacccc
3957241 cacgcctcgg cggtgaacac cgtgtcaaaa cccgcatcct cggccgcggc gacgagttcc
3957301 gcatggttct gcggcggctg cgcgccccaa taccccagct gtagtccgag cttcatccct
3957361 gcctccacga cgcccttcag gagggcaatg ttgaaaccgt tgttagaacc tgttctactc
3957421 gacaggcgtg acagccagct cgagcggccc ggcgctgatc gatcactctg agccgcccct
3957481 ttccgcgccc ctcacgttgt ccttcgacta cacccgttcg gtggggccca cgttaagcag
3957541 gtttttcacc gccttgcgtg cacgccgcat tgtcggggtg cgcggatccg acggccgagt
3957601 ccatgtgccg ccggtggaat atgacccggt tacctacgaa cccctgagcg aaatggtacc
3957661 ggtgtccagc gtcggcaccg tcgcgtcctg gacctggcaa cccgagccgc tagccggcca
3957721 gcccctggac cggccgttcg cctgggcgct gatcaagctc gacggcgccg acaccttgct
3957781 gatgcacgcc gttgatgtgg gaaccgccgg cccttccgcc atccacaccg gcgcccgggt
3957841 gcacgcgcat tgggccgacc aaccggtggg cgccatcacc gatatcgcct gctttgcgct
3957901 cggcgagacc gcagaaccgg tggcggctca caagaccgag gatgcgcggg acccggtcac
3957961 catgatcgtc acgccgatcc agctggaaat tcagcacacc gcctcgcacg aggagagtgc
3958021 gtatctgcgc gccatcgccc agggcaagct cgtgggcgcc agaaccggaa agaccggcaa
3958081 ggtatacttc ccgccgcatg gcgccgaccc ggccaccggg aaacccacct ccgagtttgt
3958141 cgagctgccc gacaagggca cggtgacgac gttcgcgatc gtcaacatcc cgttcctggg
3958201 ccagcgaatc aagccgccct atgtggcggc ctacgtgttg ctcgacggcg ccgacatccc
3958261 gtttttgcat ttggtttccg acgtcgacgc gcaccaggtg cggatgggca tgcgcgtcga
3958321 ggcggtgtgg aagccgcggg agcggtgggg actgggcatc gacaacatcg agtacttccg
3958381 ccccaccggc gaaccggatg ccaactacga cacctacaag caccacctgt aaagggccca
3958441 ccaaccaatg agcgttcgcg atattgccgt tgtcggcttc gcccacgccc cgcacgtgcg
3958501 ccgcaccgac ggcactacca acggcgtcga gatgctgatg ccgtgcttcg cccagctata
3958561 cgacgagctg ggcatcacca aggccgacat cggattctgg tgttcgggtt cgtcggatta
3958621 cctggctgga cgagcatttt cgttcatctc cgcgatcgac tccatcggag ccgtaccgcc
3958681 gatcaacgaa tcgcacgtcg agatggacgc cgcctgggca ctgtatgagg cctacatcaa
3958741 actgctgacc ggcgaggtcg acaccgcgct ggtgtacggc ttcgggaagt cctcggccgg
3958801 aacgctgcgc cgtgtgctgt cccgccagac cgacccgtac accgtcgcgc cgctgtggcc
3958861 ggattcggta tcgatggcgg gactacaggc gcggttgggg ctggactccg gcaagtggac
3958921 ccacgagcag atggcgcgag tggcgttcga ttccttcacc aacgctcgcc gggtggattc
3958981 cgtggagccg ccgatcaccg tcggggaact gctggcacgg ccgttttttg ccgatccgct
3959041 gcggcgccac gacattgcgc cgattaccga cggtgccgcc gcggtcgtgc tcgcggccga
3959101 caaccgcgcc cgagaactgc gcgaaaatcc ggcgtggatc accggaatcg aacatcgcat
3959161 cgagtctccg gcgctggggg cgcgcgacat caccgagtct ccgtcgacca aactggcggc
3959221 caagatagcc accggcggac acaccggcga catcgacgtg gcggagatcc atgggccctt
3959281 tacccaccag cacctgatcg tcgcggaggc catcaggatt ccgggtaaga cgaaagtgaa
3959341 tccgtccggc ggcccgttgg ccgccaaccc catgttcgcc gccggccttg agcgtatcgg
3959401 ctttgccgca caacatacct gggacggatc ggcgcggcgc gtgctggcgc acgccaccag
3959461 cggaccggcg ctgcagcaaa acctggtcgc ggtcatggaa ggacggggat agtggagggg
3959521 cagcgctgat ggccggaaag ctggccgccg tactcggcac cgggcagacc aagtatgtcg
3959581 ccaagcgcca agacgtttcg atgaacggtc tggtgcggga ggccatcgac cgagcgctgg
3959641 cggattccgg ttccaccttc gacgacatcg acgccgtcgt ggtcggcaag gcgcccgact
3959701 tcttcgaagg ggtgatgatg ccggagctat tcatggccga cgccatgggc gcgaccggca
3959761 agccgctgat ccgggtacac accgccggtt cggttggcgg atccaccggg gtagtggctg
3959821 ccagcctggt gcaatccggc aaataccgcc gggtcctggc attagcctgg gaaaagcagt
3959881 cggaatccaa tgccatgtgg gcgttgtcga ttcctgtgcc gttcaccaaa ccggtcggtg
3959941 ccggtgcggg gggatacttc gccccgcatg tccgggccta tatccgccgc tcgggcgcac
3960001 cggcacacat cggtgctatg gttgcggtca aggaccggct caacggcagc cgcaacccgt
3960061 tggcacatct gcagcagccc gacatcaccc tggagaaggt gatggcatct cagatgctct
3960121 gggatccaat acgtttcgat gagacgtgcc cgtcgtcaga cggtgcgtgc gcggttgtcg
3960181 tcggcgacga ggagatcgcc gacgcgcgac tggcgcaagg gcatccggtg gcctggattc
3960241 atggcaccgc attacgcacc gagccgctgg ctttcgccgg gcgcgaccag gtcaacccgc
3960301 aggccggccg cgacgcggcg gcggcgctgt ggaaggccgc gggcatcacc agccccatcg
3960361 acgaaatcga cgccgccgaa atttacgtcc cgttctcctg gttcgagccg atgtggttgg
3960421 agaatctggg atttgcccgc gagggcgagg gctggaagct caccgaggcc ggcgagactg
3960481 cgatcggcgg tcgactaccg gtgaaccctt ccggcggcgt gctgtccgcc aatccgatcg
3960541 gcgcatcggg cctgatccgc ttcgccgagg ccgcgatcca agtcatgggc aaggcggagg
3960601 cgcgtcaagt tccgggtgcg cgaaaggcct tggggcacgc ttacggtggc ggctcgcagt
3960661 acttctctat gtgggtggtc ggctgcgaga aacccaaaca ggcagccgca taatcgcccg
3960721 gcgcgatccg ggcgacgccg cagaccatcc gagcatggtg aagttcacac ccgatagcca
3960781 gacgtcagtt ctgcgcgcgg gcaagtgctc aggtactctt tctccgtcgc ggtcgcgatt
3960841 gcaaaggggg agctggccgg tggattccga acgccgacgc tacgggtggc cgcggaatcg
3960901 acgcacctta gccattactg gagctgcagt cgttgtcgtg gtgaccctcg cagccattgg
3960961 ttacctgatc tttgagccaa aaatttctgg gtcgtccacg tccaggcagg ccgcatcgcc
3961021 aaccactcct tccccgccca gccaggtcgt ggtgccgatc gacctttgga atcccgacgg
3961081 ggtgacggtg gacctggcgg acgccgttta cgtggccgac tccggtcaca agcgactgct
3961141 gaaactgccg gccggctcca acaccccgac cacgttgcca ttcaccgaca ccatcggtcc
3961201 aggcggcgtg gcggtaaaca gcaaccgcga cgtctatgtc atcgatgaag acagccacca
3961261 tgtgttgaaa ctcgcggccg gcatcgaacc cccggtcgag ctcccgttcg gcagccttgg
3961321 cgatgcgcat ggtttggcag tggaccgcag cgacagcgtc tatgtcgtcg actatgacaa
3961381 tgccaaagtg ttgaaactgc ccccaggcgc agatacccct accgaactgc cgttcgtcgg
3961441 gctcgaccac ccctatgatg tggcggtgga cggtgctggc accgtctacg tgaccgacag
3961501 cggccacaat cgcgtggtgg cgttgaccgc ggggtcggcc acgccggtgc acctcccatt
3961561 cgccgatctc agctttcccg ccggtgtgac ggtggaccgc gacgatagcg tctatgtggc
3961621 cgatctgaac aacaatcggg tgctgaagct ggcggccggc tcgaatgcgc agtcgcagct
3961681 gccgttcacc ggactcttct ccccaactga tgtggcggtg gacaacgacg gcgccgtcta
3961741 cgtgatcgac ttttacaacc ggatgttaaa actgccgacg gcttaacccg cagcgacgcc
3961801 tacatgggtt ccagtccggc cagatgccgt gcagccaggt cacgataggc ctgcggattg
3961861 acgttaaccc acatttccgc gcccgttcct tcaatcggtc ccttcacctt ggccggcgct
3961921 cccgttacca gcattccggc cggaatctga gtgccggcca ccaccagcgc tcccgcggcg
3961981 atcatgcagc gcgcgccgat taccgctccg tcgaggaccg tcgcgtggtt ggcgatcaga
3962041 gcctcagacc cgacgtggac gccgtggatc acacacaggt gcgccactgt cgcccccggg
3962101 ccgatgtcta ccgggatgcc gggcggtgcg tgtaataccg ccccgtcctg cacattggcc
3962161 ccctcgcgca cgacgacggg cgcatagtcg ccgcgcagca cggcattgaa ccagaccgac
3962221 gccccagcct cgatggtgac gtcgccgatc agggtggctg tcggggccac aaacgcggtg
3962281 ggatcgatcc ggggcgatcg gccctcgaaa gaaaacagcg gcatcgttta gatatacgcc
3962341 cgtcgtacat atgccgtggc cagactcgct gtcgttgcgc tcaccggaga gaaaactgta
3962401 acgtgttcta gttagcgata ccgatcggga ggtgacaggt gagtaccgac acgagtgggg
3962461 tcggtgttcg ggagatcgat gccggcgcct tgccgaccag gtatgcgcgt ggctggcatt
3962521 gcctgggcgt cgcgaaggac tatttggaag ggaagccaca cggggtagag gcgttcggca
3962581 ccaagctggt tgtgttcgct gattcccacg gggacctgaa agtcctcgac ggctactgcc
3962641 ggcacatggg cggcgacctg tccgagggca ccgtcaaagg cgacgaggtc gcttgcccgt
3962701 tccacgactg gcgctggggt ggcgacggcc gctgcaaatt ggtgccgtat gccaggcgca
3962761 cacccagaat ggcgcgcact cggtcgtgga cgaccgatgt gcgcagcggg ctgctgtttg
3962821 tctggcacga ccatgagggc aatccacccg accccgcggt ccggatcccc gagattcccg
3962881 aggcggccag cgacgagtgg accgactggc ggtggaaccg catcctcatc gaagggtcca
3962941 actgccgcga catcatcgac aacgtcaccg atatggcgca cttcttctac atccacttcg
3963001 gtttgccgac gtacttcaag aacgtcttcg agggccacat cgcctcgcag tatctgcaca
3963061 acgtgggccg gcccgatgtc gacgatctgg ggacgtctta cggtgaggcg catctggatt
3963121 cggaggcgtc ttacttcggg ccgtcgttca tgatcaactg gctgcacaac cgctacggca
3963181 actacaagtc cgagtcgatc ctgatcaact gccactaccc ggtgacccag aactcgttcg
3963241 tcctgcaatg gggcgtcatc gtcgaaaagc ccaagggtat gagcgaagag atgaccgaca
3963301 agttgtcgcg ggtgttcacc gagggcgtca gcaagggctt cttgcaggat gtcgagatct
3963361 ggaagcacaa gacccgcatc gacaacccgc tgctggttga agaggacggc gccgtgtatc
3963421 agctgcgccg ctggtatgaa cagttttatg tcgacgtagc cgacataaaa ccagagatgg
3963481 tggagcgctt cgagatcgag gtcgacacca agcgcgccaa cgagttctgg aatgccgagg
3963541 tagagaagaa cttgaaatcg agagaagttt ccgacgacgt gcccgccgag caacactgac
3963601 ggacatgcct gacgatcagc cggcggttcc cgacgtcgat cggctggccc ggtcgatgct
3963661 actgctgcac ggtgatcatc acgatcacaa cgattccccc gagcaacacc gcacatgtgg
3963721 atcctggtcg aagtcaaggg atttcgctga cgacccgcag cgtgctgccg cggtgcgcga
3963781 agccagccgc gccgagcgcg accgttatct gacctcaggc ctgcaaccgg tggattgccg
3963841 gttctgccat gtcacggtga ccgtaaagag gctggggccg ggtcataccg ctgtgcaatg
3963901 gaacaccgag gcgtcgcggc gctgcgcgta cttcaccgag ctgcgggcac gcggcgggga
3963961 ttccgcacgc accaggtcct gtccccggct gaccgacagc atcgaacacg cagtggccga
3964021 gggctacttg gagcaccacg acccaaaccg ataacgtcgc acacccgctt gccgcgggat
3964081 acggtgccgc atccggcacg gtgccaccga ggcgtacggt ttgtgacggc ggttccggga
3964141 ctgagcttcc tatgaagcct ctccggtgtg cgcgagtcga tcgaggcgca ccagagcatc
3964201 gtgttcgccg ccctggcggt cagaactgga ttgaacacca aacaggttgg agcatcaaga
3964261 aattcgttca aacactacgt cgctaccgca ccgtgacccc gcgccggcaa ccacaccctc
3964321 cgtgcgggac cttcagggtc cgatgcaaga gcaccggtct gttggatggg gatgcgactc
3964381 gtaggcgatg ccctgtccat tcactcgaga tccattcact cgaggtcgac ttcgcccggc
3964441 ccgccccgca tctcacaaaa cgagggttta ctgtgacctt attgtcgcgc aaaaagaaag
3964501 gcccgattct gaatattggg cagccagcca aatccgcggc aatcctcctt gtagagcagc
3964561 ttgaaaccga gttcagaagc ttttgattcg agatcagcgt cggtgatacc ccattgccag
3964621 atgtctggta tatcgcgcca cggcttgtca tgatccgggt gctttttatc gagtttttga
3964681 aagagatctc tataagcctt gttaagtttg ctgtgcggga cgttacgaaa gtagtgcttt
3964741 tcacccagat ccaacaatct aactgtggtt gttgaaccta tccattgttg attataaatc
3964801 agcaaacaac gtacattctt tgcgtacata tccaggatag tgtcccaatc aggcgacact
3964861 tggtgcagca gcacatcgaa taggaagagg gcgtcgacat taccgacttt atcggcaatc
3964921 tcctggtctc cgaagttccc ctcaataacg cgaagttgcg gatatgaatt tgcacgggcc
3964981 gcgactgttg gagttatgcg gccatcgacc aatactgcct cttttaccgg gtacttatcc
3965041 agggcgcgaa atgtataggc gccttccact ccccaaacgg caccgagatc cgcgaacgac
3965101 tctatgcgac atgatgtgaa agcccgatct atcaggttga ttttgcctct aacgagccaa
3965161 tagccaccct gtcgtaaccg atccaacatc atttcacctc aaatacgtgt gttcaactgg
3965221 cgtctcgctg gatggtagat caccgctagc tggtccagta tgccgcctgc catgagcttg
3965281 ggaccagtgt gatctgcttg tgccaggggg aggacgggac caccttgatt gccagtcacg
3965341 ggaccacggc gcgccgcgtc ggtggtcttt tcgcttattc gtgcgatcgt cgtgacagct
3965401 caagtcacgg gaggcggcgg gcatggcttt tcgggaggtc agtatgaaca agatcaggga
3965461 agtgctgcgg gtctggctgg gggtggccgg gttgccggcc ccggggtgcc gcacgatcgc
3965521 cgcgcattgc ggtatggacc gcaagacggt gcggcgctac gtggaggccc gcgcaggcac
3965581 ccggtctgcc ccgcgacgac gatgtcagcg ctatcgatga cgggttgatc ggggcggtcg
3965641 ccgacgcggt gcgtccggcc cggccggatg gtcatggtgc ggcgtgggag caactgctgg
3965701 gggtagcgaa ctgttcacta ccccctggca atcaggtggt cccgtctccc tggcaagcga
3965761 cagctcgggc aatccacctg gtaatcaaac aatttcgggc ggctggcgag ttgtcgcgct
3965821 gaggcgggca aattgcgtat ctgctcgacc aatgcgacgc ggctggccaa acagcacacc
3965881 gaatcacagc ccggcgaacc gctctttgac catttcgacc gtgagcccgt agtcagccaa
3965941 cgaataggaa tgctttgggg cccgggcacc gctctggctc tcggcgtgga cggttgtcat
3966001 tgcctgtcga gcctcgtcgg acagcgtcaa cccgaagtgc cggtagatat ctgccaccgt
3966061 acccagcgga tcggcaatca agtcgtggta gtccacgtcg tagaactggg ccgaatcata
3966121 tttggcccgt gcggcattga accgctccag cccacgcgac caggtgtcca tcgcgtccgc
3966181 accgatctgg gcgcccacaa acttcgtcga ccacccttct gtggtgtgct gcgccagcga
3966241 gcacatcgac gccatgatcg tctccaccgg ccggtgagtc tgcaccacca gggcatcggg
3966301 ataggtcgcc atcagcgcat ccagggcaaa tagatgactc ggattcttta gtacccaccg
3966361 cttttcggca tcgttgagcc caatcagctg caggttgcgg cggtgccggc aatacgacgg
3966421 cgtccagtcc tggcgtgaca accagtcggc atagctgggt acatgcgcca gcgcctcgta
3966481 cgacaccgaa tgcagcgact gccgcaacag ctgccaacac tcctccaact cgtaggccgc
3966541 catgaaatgc aagccggtgt atcccggatt ctcggcatga tgctgggtga actgtgcatc
3966601 gagctggcga tacaacgggt ttgactccca ggtctcgcgc ggggggcgcg gctgcgggta
3966661 ctcggccagc cacatgtgca ggccttggtg ggccgggtcg gcgcccagca gccggtgcag
3966721 cgcagtggtt ccggtgcgca ccaacccggt gacgaagata ggccgtttga tggcaacgtc
3966781 gacgtgctcc ggatactgct tccacgcgga ctgggacagt agcctggcca ccagcgcacc
3966841 gcgcaggaag aaccggttca tcttgctgcc caacacggtg aggccggctt cgccctggta
3966901 agcgtccagc aacacaccca gcgcctcacg gtagttgtcg tcgtcggtgc caaaatcgtc
3966961 gagacccacc agtttggtag ccgatgcgtg cagttcgtcg acggtggcca catctttccg
3967021 atcgggacgc cgagtcatta cgtgtggtac tccccgcaat tgacgtccag ggtctgcccg
3967081 gtgatgccgc tggccaggtc gctggccagg aaaagaatcg ctgaggccac ctcgtcttcg
3967141 gttggcagcc gtttgagatc ggagtttgcc gcggtcgcct gatagatctg atccacggta
3967201 gtgccgtatt tgccggcctg atggtcgaaa tagcttttca gcgtgtcacc ccagatatag
3967261 ccgggtgcaa cggaattgac gcgaattccc tgctcgccca gttccgtggc cagcgaatgc
3967321 gacatagcta gcagtacgga cttggccatc ttgtaggtgc cgtatttcgg ctgcgagtgc
3967381 cggatcacca tggagttgac gttgacgatc gcgccgtgag actgcgccag cgcgggcgta
3967441 aacgcctgga tgagtcgtag cgtccccagc gcgctgagct ctatcgcgtc acggatgtgc
3967501 tcaaatgtgg tgccggccaa tggtttcatc gatggcaccc ggaacgcgtt gttgatcagc
3967561 acgtcggcct tgccgtacgc cgccagcgtg gcctgcacaa ggttgcttac gtcgtcgtcg
3967621 tcggtgatgt cggtgcgcac cgccaccgcc cgtcgcccgg tgtcgatgat ctgcttggcg
3967681 acgtcgtcga gacgctccgc gctgcgcgca gccagcacca gatcggcgcc gtctcgcgca
3967741 catcggtgcg ccagcgtcgt gcccagcccc ggtccgacgc cactgacgac gatcaccttg
3967801 cgcttgagca tcccggtcat cccagcatcc tggtcgcgat ttgccgttga cgcaacgcaa
3967861 ttcgcgcccg ccaatcatcc tcggaaatct tgttgtgctg gtaatgcggc agtgccgccg
3967921 ggatggcgtc gaagtcgacc agttcgacgg tgggcccatc ggcctcggtg agctcacggg
3967981 atacccgctg ccagcggaac tgcagaaacc cgcgccgatg gccgagcgtt tccacccagt
3968041 tggtcacacc cggattctgc tcggcgacca cgatgcgcac cttgccatcc gggtccgctt
3968101 gggcctggct ggcattcaac gaggtctgat gattgatata gtccagcgag atgtaccaca
3968161 tgctgcccaa ctgaaaccct aagtaggggg cgtcgctcac cggcaccgtg atcaccagcg
3968221 cttgacccgg ccgcagctcg aaatgaccgg ccgacgagta ttgggtggcc aggccaccgg
3968281 gagtcaaccg aggcgccacc atggtgttaa ccgggatatt gaggtagaac cactggggaa
3968341 actgtaacca ggttttcacc cggttcacaa gctgggatcc cgctgtggca taacgctttt
3968401 ccatgagctc gcgagtcagc ggcggcggcg cggtgccgac ggtgtccagc ctggcgatgg
3968461 ccagcgtgcc gcgctgttgt gaccaatcgc cgtacacctc ccggatcact agttgcccgg
3968521 gagcgctggg ccgcaaccgc cattcgaagc tgccgtccgc ggcgatgtcg agctcacggt
3968581 cgtcgaacgc ggcctggctg gccggcacgt tatagtcggt gtactcgccg ccgagcagct
3968641 gaaagctcag gtcggtggtg gtgccgcgcc gtccgctgac cacatagtcg cggttggcct
3968701 gcagccgggt gccgaagtag agggtgtcgg ggttgtccag gcccatcttc gtgaacggcc
3968761 ctgttccgga ctgcaggaac gggtggtcac gctcgtagtc gaaggccagg tgcatgcagc
3968821 ccgcgatgca gccggccagg tattgcagcc cttcgagcag gtcggcttca gtctcgatgt
3968881 gcggggcggc ggctaccagc tgctcggctt ctgcgatcgc ctcgcgcagc gggtcggagt
3968941 acacgacttc gacactagaa cgtgttcctg ttttgcgtca atggcgaaca tctgcccccg
3969001 tcatttacgg caattgaaga caaagcccgc tcgcttccag agccctgcgc acgagctacc
3969061 cattattgat ctagcttatt gttgcgttat acgacagtct gagcagtata ttgtccgcta
3969121 tatgtgtatt cgtagcggcg tggattgacg cgaggctggt cgagacccgg tccgtgagat
3969181 gcgccggaaa gggtgtcgcg atgcggaact ctactgaccg tccagcggcg gctaacgaag
3969241 tctgcatccg cgacagccac ccaatgacgc gcctgccgtt gcgatctcag cactgacggc
3969301 agcccggcct atccgcgacc agctagggaa aggcattcgc agatgttcat ggatttcgcg
3969361 atgcttccgc cggaagtcaa ctcgacacgg atgtatagcg ggccgggagc gggctcgttg
3969421 tgggccgccg ccgccgcctg ggatcaggtg tcggcggaat tgcagtcggc ggcggagacc
3969481 taccgctcgg tgatcgccag cctcaccggc tggcaatggc tgggtccatc gtctgtgagg
3969541 atgggtgcgg cggtcacccc gtatgttgag tggctgacca ccaccgccgc gcaggcaagg
3969601 cagacggcca cccagatcac cgcggccgcg accggatttg agcaggcgtt cgccatgacg
3969661 gtgccgccac cggcaatcat ggccaaccgt gcacaggtgc tatcgctgat agcgaccaac
3969721 tttttcggcc agaacaccgc ggcgattgcg gccctggaga cccagtacgc cgagatgtgg
3969781 gaacaggacg ccaccgccat gtacgactac gcggccacct cggcggcagc gcggactttg
3969841 acaccattta cctccccgca gcaagacacc aactcagccg gtctgccggc gcaaagcgcc
3969901 gaagtcagcc gcgcgaccgc caacgccggc gccgccgacg gcaactggct gggaaacctc
3969961 ctggaagaaa tcggaatact gctgctgccg atcgcgcccg agctgacacc ctttttcctg
3970021 gaggcgggcg aaatcgtcaa tgcgatacct ttcccgagca tcgtcgggga cgagttctgt
3970081 ttgctcgacg gcctactggc ttggtacgca acgatcggct cgatcaacaa catcaattcg
3970141 atgggtaccg gcatcattgg ggccgagaag aatttgggga tcttgcccga gctagggagc
3970201 gcggctgcgg cggccgctcc cccaccagcc gacatcgccc cggcgttcct cgcgccgctg
3970261 accagcatgg ccaagtcact atcggacgga gcactacgcg gcccgggcga agtttcggcc
3970321 gcgatgcgcg gcgcgggtac catcgggcaa atgtcggtgc cgcccgcctg gaaggcgccc
3970381 gcggtcacca ccgtcagggc gttcgatgcc accccaatga ccacactgcc cggcggcgac
3970441 gcccccgccg ctggagtgcc tggactgccc gggatgccag cctcgggggc cggacgggct
3970501 ggcgtggtgc cccgatacgg cgtacggctg accgtgatga cacgtccact ctcgggcggg
3970561 tgacatcagt gcgtgatggc ggcgcacctt gaccgtcgcg cattgcgctt ccaacaccaa
3970621 cgaactggga ctgcagtagt agcgcaaccg cgcttggagc gggtccccac cggttatggc
3970681 attcgatacc gcaccaaagc gaaatcagtt cccgaacccc gaccgctggt tctcgctgtt
3970741 gaagccgccc gagttgtgga cgcccgagtt gaagaatccg gagtttaaga cgcccgagtt
3970801 tgcgataccc accgtttggg cgccggtgtt tccgaaaccc gccgcgatga cggtgccgac
3970861 cgcgttttgc aggcccgagt tgttgctgcc cccgttctgg aaccccgagc tgccaacgcc
3970921 cgtgttgaag aagcccgagt tgttcgtgcc ggcgttgccg aaacccgagt tcgggccgga
3970981 gccggtgccg acggcgccga acccggtgtt gagcgaaccc gcgttgaagg cgccggtgtt
3971041 agtgaggccc gagtttgacc agccggtatt tctgacgccg gcgttgaaat caccggtatt
3971101 gccttgtccg gaattgaagt tgcccgtgtt gatgctgccc gcgttgaagc tgcccgcatt
3971161 caactggccc gagttcccga agccgaggtt tattgcgccg ccgtttccga aaccggtatt
3971221 cacgcccccg gcgtttccca tgcccgtgtt gagcgaaccc gagttcccga aaccggtgtt
3971281 atggcccgcc acgaacgggc ccacggtggc ccccgagttt ccgatgccca cattcgcgtc
3971341 gctggagttg ccgataccca ggttgccgtt gccggagttg aagaaaccga cgttgttggt
3971401 gcccgagttg aacaagccga tgtttccgct gcccgagttc agcccaccga tgcccacctg
3971461 gttgttgccg gtgagcccga agccgatgtt gccgttgccg gtgttgccga aaccgatgtt
3971521 gccaatgccg ttgttgccga agccccagtt gctgctgccg gtgttcccgg cgccgatgtt
3971581 gccgctgccg gcgtttccgg tgccgacgtt gttgttgccg gtattcccga acccgacgtt
3971641 ggagttgccg gtattgccgc tgcccaggtt gctgttgccg aggttcccgt tgccgacgtt
3971701 cccactgcct ggaagtcccg ccctcccgtt gccgctgccg aagttgccgt tgccgacgtt
3971761 cccgccgccc acgttggagt tgccgatgtt gccgctgccc aggttcgcgt caccccggtt
3971821 cccgctgccc aggttggtgt taccgatgtt gccgttgccg gtgttcaggt cgccggtgtt
3971881 gccgccgccc aggttggcgt tgccgatatt gccgataccc aggttcggca gctgctgcag
3971941 cgcctgctga aagggcacca actgctcggc cgccgccgag gccccggagt ggtagcccac
3972001 catcgcggcc acatccgcgg cccacatctg ttcgtaggcg ccctcaacgg ccgcaatcag
3972061 cggcgcgttc agcccgaacc aattcgacat caccaactgc gcaaacgcat tgcggttggc
3972121 cgccaccagc aaagggtgca ccgtcgccgc ccgtgccgcc tcgaacgcgc tggccaccgc
3972181 cttggcctgg gccgccgccc ccgcggcccg ggccgccgca gcgctcaacc atcccgcata
3972241 cggtgccgcc gccgccgcca tcgccgccgc cgccggcccc tgccacgcct gacttgccaa
3972301 gtccgaggtc accgacccaa acgaggacgc cgcggacccc aactctgcgg ccagcccgtc
3972361 ccaggccacc gccgccgcca acatcggcgc cgaacctgca cccgtgaaca tccgcaacga
3972421 attaagctcc ggcggcaata ccgcatagtt catgaccccg tcccttcccg acctgacaat
3972481 cagtcagaac cgtaggacaa accgggtcgg accatctgcg tttccgtgaa atccgcgaac
3972541 cagcggtgtc gtcaatgcgt tacggccgca ccgctatcca gctcgcgttt gatttccagc
3972601 gcgatgtcga tgagctggtc ttcctggcca ccgatgagct tgcgctgacc ggcccggtgc
3972661 aacagcgccg acgccggcac gccgtagcgc tcggcctggc ggaccgcatg cttgaggaag
3972721 ctggagtaga ccccggaata ccccatgatc aacgcgttgc ggtcgagcag acattcggcc
3972781 ggcatggccg ggcgcaccac gtcctcggcg gcgtcggcaa tgtcgaagaa atcaatgccg
3972841 gtcttgacgc cgatcttgtc gaacaccccg atcagcgcct cgaccggcgc gttacccgcc
3972901 ccggcgccga aacgccggca ggacccgtcg atctgcttgg cgcccgcgcg caccgccgcc
3972961 accgaattgg ccaccccgag accgaggttc tcgtgcccat gaaagcccac ctgggcgtct
3973021 tcgccgagct cggcgaccag ggccgacacc cggtcggcca cgccgtcgag caccagggca
3973081 ccggcggagt cgacgacgta gacacactgg cagccggcgt cggccatgat gcgggcctgg
3973141 gcggccagtt tctccggcgc aatggtgtgg gccatcatca aaaacccgac ggtttccaga
3973201 cccagttcgc gggccagccc gaaatgctgg atcgacacgt cggcctcggt gcagtgggtg
3973261 gcgatccggc agatcgaccc gccgttgtcc cgcgcctctt tgatgtcgtc cttggtgccc
3973321 acaccgggca acatcaaaaa cgcgatccgg gcctctttcg cggtcgccgc ggccagcttg
3973381 atcagctcct gctcaggggt tttcgagaag ccatagttga acgatgagcc gcccaggccg
3973441 tcgccgtggg tcacctcgat caccggcacg ccagcggcgt ctagggcggc cacgatggca
3973501 ccgacctcgt ccttggtgaa ttggtggcgt ttgtggtgcg acccatcccg cagcgaggtg
3973561 tccgtgatgc ggacgtccca catatcggtc atcgcgctcc tcctacaacc agcgtctcct
3973621 tggcgatctc ctcgcccacc ttggtggccg ccgcggtcat gatgtccagg ttgcccgcat
3973681 agggcggcag gtaatccccg gcgccctcaa cctcgacgaa cgtggtgacc agcgcctgcc
3973741 cgcccgagtt gatcgacggc tcgtcgaact gcggttcgtt gagcagccgg tatccaggca
3973801 cgtaggtctg cacctctttg acgacgtcgt ggatggaggc ggcgatcgct tcgcggtcgg
3973861 cgtcggtggg gatggcgcaa aagatggtgt cgcgcatgat catcggcggg tcggcgggat
3973921 tcaagatgat gatcgccttg ccgcgggcgg ccccgccgat ggtctggacc ccacgggcgg
3973981 tggtcttggt gaactcgtcg atgttggcgc gcgtgcccgg tcccgctgaa acggaagcca
3974041 ccgacgccac gatctcggcg tagggcacct ccacgatccg agacaccgcg tacacgatcg
3974101 gaatggtcgc ctgtcccccg caggtgatca tgttgacgtt cggcgcgtcc aggtgctcgc
3974161 gcaggttcgc cggcgggatc accgccggac ccaccgccgc cggcgtcagg tcgatggccc
3974221 ggatcccggc ctcggcgtac ttgggcgccg cgtcccggtg cacgtaggca ctggttgcct
3974281 cgaacaccag gtcgggttta tcgggctgcg ccagcagcca gtccaccccc tcgtgggtgg
3974341 tctccaaacc cagcttggcc gcgcgcgcca ggccatcgct ctccgggtcg atgcccacca
3974401 tccagcgcgg ctccagccac tccgatcgca gcagcttgta cagcagatcg gtgctgatat
3974461 ttcccgaccc gacaatcgcc acttttgcct tggacggcat gttgctcccc ttattcgaac
3974521 gacaaccgga ccaaacccag cccggtgaag tcggcgacaa actcgtcgcc ggcccgcgcc
3974581 tcgaccgcga acgtgcatga cccgggtaac acgatgtcgc ctttgcgcag ccgcacgccg
3974641 aaactctcga ccttgccggc cagccaagcc accgcggtcg ccgggttacc caacaccgca
3974701 tcactgcggc cctcggccac cacctcgccg ttgcgggtca gcttcgcatc gatcgccctg
3974761 acgtcaagat cggccggcgg cacccgggcc gcgcccaaca cgaagcccgc cgccgaggcg
3974821 ttgtcggcga tggtgtcgca gatcttgatc tgccaatcct tgatcctggt gtcgatcagc
3974881 tcgatggcgg gcaccagggc ctcggtggcc gccagcacgt cgtcctcggt gcagcccgca
3974941 cccggtaggt cggcggccag gatgaagccc acctccacct caacccgcgg agacaggtac
3975001 cgggacgcct ggaccggcgt gtcttcgaac acctgcatgt cgtcgagcag gtgtccgtag
3975061 tctggttcgt caacccccat catctgctgc atgatcggcg acgacagccc gaccttatga
3975121 cccaccacgc gggcaccctc ggccacccgc tgccggatgt tgatcaactg gatctcgtag
3975181 gcgtcgacga catcgatctc gggatgggcg gcggtcagtt gaccgatcgg gtcgcggctt
3975241 cgctcggctt gtgctaggtc ggcggccagc tcatcacggg tggcatcacg gagcattcgg
3975301 cgaagtcccc tcgtaggcgt gaccgggcca gtagcgcccg acccgagcaa ttctataacg
3975361 tgttctacat gactgtgcag gagttcgacg tcgtggtggt cggcagcggc gccgccggca
3975421 tggttgctgc gctggtcgcc gctcaccgag gtctctcgac ggtagtcgtc gagaaggccc
3975481 cgcactacgg cggctccacc gcacgctcgg gcggcggcgt ctggatcccc aacaacgagg
3975541 tcctcaagcg ccgcggcgtt cgagatacac cggaggcggc acgcacctat ctgcacggca
3975601 tcgtcggcga aatcgtcgag ccggaacgca tcgatgctta cctcgaccgc gggcccgaga
3975661 tgctgtcgtt cgtgctgaag cacacgccgc tgaagatgtg ctgggtaccc ggctactccg
3975721 actactaccc cgaggctccg ggcggccgcc cgggcggacg ttcgatcgag ccgaaaccgt
3975781 tcaacgcgcg caagcttggt gccgacatgg ccgggctgga gcccgcgtat ggcaaggttc
3975841 cgctcaatgt ggttgtgatg cagcaggact acgttcgcct caatcagctc aaacgtcacc
3975901 cccgtggcgt gctgcgcagc atgaaggtcg gcgcccgcac gatgtgggcg aaggcaacag
3975961 gtaagaacct ggtcggcatg ggtcgagccc tcattgggcc gttgcggatc gggttgcagc
3976021 gcgccggagt gccggtcgaa ctcaacaccg ccttcaccga tcttttcgtc gaaaatggcg
3976081 tcgtgtccgg ggtatacgtc cgcgattccc acgaggcgga atccgctgag ccgcagctga
3976141 tccgggctcg ccgcggcgtg atcctggcct gtggtggttt cgagcataac gagcagatgc
3976201 gaatcaagta ccagcgggca cccatcacca ccgagtggac cgtgggcgcc agcgccaata
3976261 ccggtgacgg cattctcgcc gccgaaaagc tcggcgcagc actggatctg atggatgacg
3976321 cttggtgggg cccgacggta ccgctggtcg gcaaaccatg gttcgcgctc tcggagcgca
3976381 actctcccgg ttcgatcatc gtcaacatgt caggcaagcg attcatgaac gaatcgatgc
3976441 catacgtcga agcctgtcat catatgtacg gcggcgaaca cggccagggg cccggaccgg
3976501 gcgagaacat tccggcgtgg ctggtgttcg accagcgata ccgggaccgc tacatcttcg
3976561 cgggactaca accagggcaa cgcattccga gcaggtggct ggattccggc gtcatcgtcc
3976621 aggccgatac ccttgcggag ctggccggca aggccggtct acccgcggac gaactcactg
3976681 ccaccgtcca gcgtttcaac gcattcgccc ggtccggtgt cgacgaggac taccaccgcg
3976741 gggaaagtgc ctacgatcgc tactacggcg acccgagcaa caagcccaat ccgaacctcg
3976801 gcgaggtcgg ccacccgccc tattatggcg ccaagatggt tccgggcgac ctggggacca
3976861 agggcggtat ccgcaccgat gtcaacggac gtgctctgcg ggacgacggc agcatcatcg
3976921 acggccttta cgctgcaggc aatgtcagtg ccccagtgat gggacacacc taccccggtc
3976981 cgggcggcac gataggcccg gcgatgacgt tcgggtacct ggcggcgctg cacattgccg
3977041 atcaggcggg aaagcgctga tatgcccatc gacttggacg tcgcgctggg tgcacagcta
3977101 ccgcccgtcg aattctcttg gaccagtacc gatgtgcagc tctaccagct gggactgggc
3977161 gccggctctg atccgatgaa cccccgtgag ctgagttatc tggcggacga tacaccgcag
3977221 gtgttgccga cgttcggcaa cgtcgcggcc accttccacc tcaccacacc accgaccgtc
3977281 cagtttccgg gcatcgatat cgagctcagc aaggtgctgc acgccagcga gcgagtcgag
3977341 gttcccgccc cgctgccgcc gtcgggttcg gccagggcgg tcacccggtt caccgacatc
3977401 tgggacaagg gcaaagccgc ggtaatctgc agcgaaacga cggcgaccac accggacggc
3977461 ttgctgctgt ggacgcagaa gcggtcgatc tatgcccgtg gcgaaggcgg attcggcggc
3977521 aagcgcgggc cgtcgggatc agatgtcgcg ccggagcggg cgcccgatct gcaggtcgcg
3977581 atgccgattc tgccgcagca agcgctgctc taccggctct gcggcgaccg caacccgctg
3977641 cactcggatc ccgaattcgc cgctgccgca ggctttcccc ggcctattct gcatggcctg
3977701 tgcacctatg ggatgacctg caaggcgatc gtcgatgcat tgctggactc cgatgcgacg
3977761 gccgtggccg gctacggcgc acgctttgct ggcgtggcgt acccgggcga gacgctcacg
3977821 gtcaacgtgt ggaaggacgg ccgccgcctg gtggccagtg tcgtcgcacc cactcgtgac
3977881 aacgctgtgg tgctcagcgg agtggagctg gtgccggcat agcggtgcgg tcggcgctaa
3977941 aggtttggtg agactgcgga tttcgcagaa gtcgacatga cattgctgct atggtctgcg
3978001 gtgacggggc cgtcgcagtg gtggcgcggc ggttgggccg agccggcggg atgttgtcat
3978061 ggcggatttc ttgacgttgt caccagaggt gaattcggcc cggatgtacg cgggtggggg
3978121 gcccgggtcg ctatcggcgg ccgcggcggc ctgggatgag ttggccgccg aactgtggtt
3978181 ggcggcggcc tcgttcgagt cggtgtgctc cggcctggcg gaccgttggt ggcaagggcc
3978241 gtcgtctcgg atgatggcgg cgcaggccgc ccgccatacg gggtggctgg ccgcggcggc
3978301 cacccaggca gagggagcag ccagccaggc tcagacgatg gcgctggcct atgaagcggc
3978361 gttcgccgca accgtacacc cggcgctggt cgcggcgaac cgcgccctcg tggcctggtt
3978421 ggcggggtcg aatgtgttcg ggcagaacac cccggcgatt gcggccgccg aggccatcta
3978481 cgagcagatg tgggctcagg atgttgtcgc gatgttgaac taccatgcgg tggcctcggc
3978541 ggtcggggcg cggttgcggc cgtggcagca gttgctgcat gagctgccca ggcggttggg
3978601 cggcgaacac tccgacagca caaacacgga actcgctaac ccgagttcaa cgacgacacg
3978661 cattaccgtc cccggcgcat ctccggtgca tgcagcgacg ttactgccgt tcatcggaag
3978721 gctactggcg gcgcgttatg ccgagctgaa caccgcgatc ggcacgaact ggtttccggg
3978781 caccacgcca gaagtggtga gctatccggc caccatcggg gtccttagcg gctctcttgg
3978841 cgccgtcgat gccaaccagt ccatcgctat cggtcagcag atgttgcaca acgagatcct
3978901 ggccgccacg gcctccggtc agccggtgac ggtggccgga ctgtcgatgg gcagcatggt
3978961 catcgaccgc gaacttgcct atctggccat cgaccccaac gcgccaccct cgagcgcgct
3979021 cacattcgtc gagctcgccg gcccggaacg cggtcttgcc cagacctacc tgcccgttgg
3979081 caccaccatt ccaatcgcgg ggtacaccgt ggggaatgcg cccgagagcc agtacaacac
3979141 cagcgtggtt tatagccagt acgatatctg ggccgatccg cccgaccgtc cgtggaacct
3979201 gttggccggc gccaacgcac tgatgggcgc ggcttacttt cacgatctga ccgcctacgc
3979261 cgcaccacaa caggggatag agatcgccgc tgtcacgagt tcactgggcg gaaccacgac
3979321 aacgtacatg attccgtcgc ccacgctgcc gttgctgttg ccactgaagc agatcggtgt
3979381 cccagactgg atcgtcggcg ggctgaacaa cgtgctgaag ccgctcgtcg acgcgggcta
3979441 ctcacagtac gcccccaccg ccggccctta tttcagccac ggcaacctgg tgtggtagtt
3979501 aacccaggat cagcccggac gtaggcaccc cggtgcccgc ggtgacgagc acatgctcga
3979561 cgcccgccac cgggttcacc gaggtgccgc gcagctgccg caccccctcc gcgatgccgt
3979621 tcatgccatg gatgtaggct tcgccgagtt gaccgccgtg ggtgttgatg ggcagccgcc
3979681 cgcccacctc gatcgcgccg tcggcgatga agtctttcgc ttcgcccttg ccgcagaatc
3979741 ccaactcctc caactgaatc agggtaaacg gcgtgaagtg gtcgtagagg actgcggtct
3979801 ggacatcggc cggcgtcagc cccgactgcg cccatagctg ccggcccacc aggcccatct
3979861 cgggcaggcc gtcgagttcc ggccggtagt agctgaccat cgtgtactgg tctggactgc
3979921 agccctgcgc agccgcctca atgaccaccg ggcgctgctt gaggtcccgt gcgcgcgcag
3979981 ctgacgtcac cacgatcgcg accgcgccgt cggtctcctg gcagcagtcc agcagccgca
3980041 gcggctcggc gatccacctc gaattctggt ggtcctcaat ggttatcggc ttgccgtaga
3980101 agtacgcctt ggggttgttg gcggcatgct tgcggtcggc caccgagaca gcaccgaagt
3980161 cccggctggt cgcaccagac aggtgcatgt accggcgagc gatcatcgcc acttgcgcgg
3980221 cgggcgtgga gagcccgtgc ggatacgaaa acgaattgtc cacgccggtg gagtcggcat
3980281 tctcggtcaa acgagtttgc acctgaccga accgcatgcc ggatcgttcg ttgaatgccc
3980341 gatacgccac cacgacgtca gccaccccgg tggccactgc catagcggcg tgctgcacgg
3980401 tcgcacatgc ggcgccaccg ccgtagtgga tcttggagaa gaacgtcagc tcgccgatgc
3980461 cggccgcacg cgccacggcg atttcggtgt tggtgtccat cgtgaacgtg gtcagcccgt
3980521 cgacatcggt cgggctcagg cccgcatcgg ccaacgcatc caacaccgcc tcggccgcca
3980581 gccgcagctc acttcgaccg gagttcttcg aaaagtcggt ggcgccgata ccgacgatgg
3980641 ccgcctgacc cgataacact acgaatccct catcgaaagt tccaccgtcg cggtcacgtg
3980701 gtcgccaagg gtattgcggc ccaccacctt taccgtgatc aagccgtcgt tcaccgcggt
3980761 cacctcaccg gagaacgtca ccgtgtcgta ggcgtaccac ggcaccccca gccgcagccc
3980821 aatcgacttg atcagcgccg acgggcccgc ccagtcggtg acgtagcgtt gcaccagccc
3980881 ggtgtcggtg aggatgttga cgaaaatgtc tttcgacccc tgggcgacgg ccttgtctcg
3980941 atcatgatgc acatcctgga agtccctggt agccagcgcc gttgagacga tgaacgtcgg
3981001 gtctccgtag agcttcagct caggcagcac agcaccaaca accgtcattc gtcaggctcc
3981061 catgcgtaga ggctccagtc ggggaaatcg atataggtcg ctcgtaccgg cataccgatc
3981121 gcaacacgag caggatcggc cccccgcagc tcgcccagca tgcgtacccc ttcctcgagc
3981181 tccaccagcg cgatcacgaa gggcaccgtg cgacccggaa ctttcggcgc gtgatgcacc
3981241 acgaagctga acaccgtgcc gcgaccgctg gagacgacgt agttgatcgg caccgatttg
3981301 tcttgccaca ccgccggcac cggtgggtgc cgcaggctgc catcggcaag ccgctggatc
3981361 cgcaattcgt gggccttgac tccatcccag aaaaacgcgg tgtcccgcga cgacgaggga
3981421 cgcatcatag cgtcgggatc caaatcgtca ggcaccgagc tcggagaacc cgcgggcttg
3981481 aatttgagga tgcgccaatt catctctgcg acgtcctcgt ccccgacttg ccatacgatg
3981541 tgctggttga tgaaccagcc ctcgccgagc gcggtttgct tgggtccgac gacgtcaccg
3981601 agctcggcgc tgatgctgac ttgctccccg ggcaataggt agcggtggta ggtctgctcg
3981661 cagttggtgg caaccacacc gatgtagccg gcgtcgtcga acagcttgat gatgggtccc
3981721 agcggatcgt ccttcggacg cactccgccc agacccatca tggtccacac ctgaatcatg
3981781 gccggtggcg cgacgattcc ggggtggccg gcggcgcgag ccgccgcgtc gtccacatag
3981841 atggggttgc ggtcgccgat ggcctccacc cagttgttga tcatcggctg gttcaccggg
3981901 tcacgggcca ggcgcggctt gctgggcccg gccgccttga tctgggcaac cgcttcctga
3981961 atgtcgctca ccccggtcac ctgggcaccc ttggcacttt gaggccagac gcggcgatca
3982021 tctcgcgcat gacttcgttc acacccccgc cgaaggtgat caccaggttg cgcttggtct
3982081 gggcgtccag ccagcgcagt agctcggcgg tgtcgggttc ggcggggttg ccgtacttgc
3982141 caacgatttc ctcggcgagc cggccggcac gctgaacacg ctcggtgcca aagactttcg
3982201 tggccgcggc atcggccatg ttgatgtcct caccggcgga cgctacctgc cagttgagca
3982261 actcgttgat ccgccagatc gcacgaatct caccaagagc ccgcttgacg tcgtcgtggt
3982321 cgatcggcgt cacgccgttg ccacccggca cggacgccca cgcgtgcacc cggtcgtaga
3982381 tgctggcgaa ccgcccggcc gggccgagca ttacccgttc gttgttgagt tgggtggtga
3982441 tcagccgcca gccgtcgttc tcctttccga ccagcatgtc gaccggcacg cgcacgtcgt
3982501 tgtagtacgt ggcattggtg tggtgggcgc cgtcggccaa gatgatcggc gtccaggaat
3982561 agccgggatc cttggtgtcg acgattagaa tggaaatgcc tttgtgctta gcggcattcg
3982621 ggtcggtgcg gcaggccagc cagatgtagt cggcgtcgtg tgcgccggtg gtgaagacct
3982681 tctggccgtt gacgatgtag tggtcgccgt cgcgaacggc ggtggtgcgc aacgacgcca
3982741 ggtcggtgcc ggcttccggc tcggtgtagc cgatcgcgaa gtgcgcctca ccggccagga
3982801 tcgccggcag gaacttcttc ttctgcagct cgctgccgtg cgcctgcagc gtggggccga
3982861 cggtctgcag cgtcaccgcg ggcagcggca cgtcggcgcg atgggcctcg ttgacgaaga
3982921 tctgctgctc gatcggacca aaacccagac cgccgaactc tttcggccac ccaacaccga
3982981 gcctgccgtc ccggcccatg cgccgtatca ccgcacggta ggccgggccg tgccggtctt
3983041 tctccatctc cgtgcgctcg tcgggcgaga tgagattcga aaagtattgc cgtatctcgg
3983101 cttgcagctg gcgctgctcc ggcgtcaggt caatgaacat cgcgctccca ggagctcaag
3983161 gcgatgcgag ggcccgccca gcagccgggt gaggtccttg atcgtggagt agtagcggtg
3983221 catcggatac gtgacgtcca tccccatgcc gccgtgcagg tgatggcaga tttgcatcgc
3983281 cggcggcgcc tgcgatgtca cccagtaccc gaggacgccc agatcatctc ccgcatccag
3983341 atcctcggcc agtctccaga tcaccgactt ggccaccagg tcaatggtgc gcgaggcgat
3983401 gtaaacctcg gcgagctgcg cggccacggt ctggaaggtt gacagcggct taccgaactg
3983461 cttccggttc gccacgtagt cggcggtcag ccgcagcgcc ccggcgacca gcccgtcggc
3983521 gtatgcaccc atgacggcca gcgctagctg attgacccgg tgcgcggcta catccgccag
3983581 gatgtcacag tcggcaaccg ccacgccgtc catcgtcatc acatactcgt ctgaaccatt
3983641 cgatgtgggc gtacgaacca tgcgcacacc gtcggccgtc ggcgacacca ccacgacggc
3983701 gttgtcggcg gtcaccaaca tccagtccgc ctgttcggcg tagccaacac cgactttggt
3983761 gcccgacaac cgcccaccca caaagctagt ggcaggccga tccggcagcg ccgccccggg
3983821 ctcgttgagc gcggcggtca gtactcctcc cttggccacc ccggccagga agcggtcctg
3983881 ttgctcggcg gatgccagct cgagcagcgg caccacccca agacccagcg ttgccagcgc
3983941 cggcgtgacg gcgccgtggc gacccacctc ggtgagcagc gcgccgactt cgaataggcc
3984001 cacgccgtcg ccgccgagac gttccggcac cggcagcgcc gtcacaccac cgcagaccag
3984061 cgcctcccac gagatgtccc gctccaacac cgacgtgacc acgtcggcga cggcttgctg
3984121 ttccgcagtg ggatcgaaat ccattagtga gcaaccgggc atctaccggt gtagtcgacc
3984181 tgccagtgct taatgccgtt gagccagccg gaccgcagcc gctcgggcgc cgagatcggc
3984241 ttgaggtcgg gcatgtggtc ggctacggcg ttaaagatta ggttgatcgt catccgggcc
3984301 agattcgcac cgatgcagta gtgagcgccg gtgccgccga agccgacgtg cgggttgggg
3984361 ttgcgcagga tgttaaatgt gaacggatcc tggaaaacct cttcgtcgaa gttagccgac
3984421 cggtagaaca tcaccacccg ctgacccttc ttaatctgta cgccggacaa ctcgtagtcc
3984481 cgcagcgcgg tgcgctgaaa agcggtgacc ggggttgccc agcgcacgat ctcatcggcc
3984541 gcggtctccg gacgcacttt cttgtacagc tcccactggt cggggtgttc agcgaacgcc
3984601 atcatgccct gggtgatgga gttgcgggtg gtctcgttac cggccaccgc cagcatcacc
3984661 acgaagaagc cgaactcgtc gtcggagagc ttctcgccgt cgatatcggc ttggatcaac
3984721 tgagtcacga tgtcgtcggc ggggttcttc gccttctcct cggccatctt catcgcatag
3984781 ccgatcagct ccgccgagga cgccttcgga tcgatgtggg cgtattccgg atcctcgttg
3984841 ccggtcatct cgtttgacca gtggaacagc ttgccgcggt cctcctgcgg cacgcccagc
3984901 aagcccgcga tcgcctgcaa tggcagctca caggaaacct gctcgacaaa gtctccagaa
3984961 cccgcggcgg ccgcctccgc ggcgatcttc tgggcgcgct cctggagctc gtcatgcagg
3985021 cgtccgaccg cacgtggcgt gaagccgcga gagatgatct tgcgcagccg ggtgtggtgc
3985081 ggcgcgtcca tgttgagcat gacgaagcgc tgaacctcga tgtcctcacg cgcgatgtcg
3985141 ttcttgaatc gcgggatcac cccgttttcg tagctggaga acacgtcgct atgccgcgat
3985201 atctctttga cgtcgttgag tttggtgatc gcccagaaac cgccgtcgtg aaagccgccg
3985261 cccttgccag gatcctgccc gttccaccag atcggcgccg cggaccgcag ctcggcgaat
3985321 tcggcaaccg gcagccgttc ggcgtagatt gcggggtcgg tgaaatcgaa cccgggcggc
3985381 agattggggc tgggcacggt agttctcctt actgcaatct ccactgactg gtgattccac
3985441 gacactagct gtcctagtga ggaccttctg ccagtaaaac atgccttcac cgcagacaaa
3985501 aggcattgaa gcaaccttgc ttgtcatagt aatgaaacgt gttctagcct ggccccatgg
3985561 gttacccggt catcgttgaa gccacccgca gccccatcgg caaacgcaac ggatggctgt
3985621 cggggctgca tgccaccgag ttgttgggcg cggtgcaaaa ggcggtggtc gacaaggccg
3985681 gcatccagtc cggccttcac gccggtgacg tcgaacaggt catcggcggt tgcgtgaccc
3985741 agttcgggga gcaatccaac aacatcagcc gggtggcctg gctgacggcc ggtttgcccg
3985801 aacacgtcgg cgccaccacc gtcgactgcc agtgcggcag cggccagcag gccaaccatc
3985861 tgattgccgg gttgatcgcg gccggtgcca tcgatgtcgg catcgcctgc ggcatcgagg
3985921 cgatgagccg ggtcgggctg ggcgccaacg ccgggccgga ccgctcgctg atccgcgcgc
3985981 agtcatggga tatcgacctg ccgaaccagt tcgaggccgc cgagcggatc gccaagcggc
3986041 gcggcatcac ccgcgaggac gtggatgtct tcgggctcga gtcgcagcga cgcgcgcagc
3986101 gggcctgggc ggagggccgc tttgaccgcg agatctcgcc gatccaggcg ccggtgctcg
3986161 acgagcagaa tcagcccacc ggcgagcggc gcctggtctt tcgcgaccag ggcctgcgcg
3986221 agaccacgat ggcggggcta ggcgagctga aaccggtgct cgagggcggc atccacaccg
3986281 cgggcacgtc gtcgcagatc tccgacggcg cggcagccgt gttgtggatg gacgaagccg
3986341 tggcacgtgc gcacggcctg accccgcggg cccggatcgt cgcccaggca ctcgtcggcg
3986401 ccgagcccta ctaccacctg gacggcccgg tgcagtccac cgcgaaggtg ctggagaagg
3986461 ccggcatgaa gatcggcgac atcgacatcg tcgagatcaa cgaggcgttc gcgtccgtgg
3986521 tgctgtcctg ggcgcgggtg cacgagcccg acatggaccg ggtcaacgtc aacggcgggg
3986581 cgatcgcgct ggggcatccg gtgggctgca ccggcagccg gctgatcacc accgccctgc
3986641 acgagctcga gcgcaccgac cagagcctcg cgctgatcac catgtgcgcc ggcggggccc
3986701 tgtccaccgg caccatcatc gagcggattt aacctagctg cggcagggca ccgtgcggcg
3986761 tgactgcaac atgaagcgac cgatgattag atagcgaggc ggacgcgcgc ctttggcgac
3986821 ccttggtcgc taggatcagc gtcatgccga aatcaccgcc gcggtttctg aattcgccgc
3986881 tcagcgactt ctttatcaag tggatgtcac ggattaatac ctggatgtac cgccgcaacg
3986941 acggggaggg tctgggcggc accttccaga agattccggt cgcgctgctg accaccaccg
3987001 gccgcaagac cggccagccg cgggtcaacc cgctctactt cctgcgcgac ggtgggcggg
3987061 tcattgtcgc ggcctccaag ggcggcgcgg agaagaaccc gatgtggtac ctcaacctca
3987121 aggccaaccc caaggttcag gtacagatca aaaaggaagt gctggacctt accgcgcggg
3987181 acgcgaccga cgaggagcgc gccgaatatt ggccacagtt ggtcacgatg tacccaagtt
3987241 atcaggacta ccagtcctgg accgaccgca cgatcccgat cgtggtttgc gaaccctgac
3987301 cgttcccaac ttcgccgaac gtgaagccag ggcgagaaaa cggccgaaat ctcgccctga
3987361 gttcacgctc ggcgcagata actaggcccc atagaccgga accggcggcc gcgacttggc
3987421 caacaggtcg ctgacgacgg gccccagctc ggccggatcc catttcacgc ccttgtccac
3987481 ctgcgggcca tgcgcccagc cctcggcgac ccggatgatg ccgccctcga cctcgaatac
3987541 cttcccagtg acatcgcggg actccgcact gcccagccat accaccaagg gtgagacgtt
3987601 ctccggggcc atcgcgtcga acccctcctg cggcttggcc atcatctccg cgaacacagt
3987661 ctcggtcatg cgggtgcgcg ccgccggcgc gatcgcgttg acggtcacgc cgtaccgcct
3987721 catttcggcg gcgccgacga gcgtcagcgc cgcgattccg gccttggcgg cgctgtagtt
3987781 gccctgcccc acgctgccct gtaggcccgc gccagagctg gtgttgatga tccgcgcgtc
3987841 aatgtctttc ggggctttgc ccgccttgga cagtccccgc caatgggacg cggcgtgccg
3987901 catggtggcg aagtggccct tgaggtgcac cgcgatgaca gcgtcgaact cctcttcgct
3987961 ggtgttggcg atcatccggt cccgcacgat gccggcattg ttcaccagga cgtccacacc
3988021 accgtacgtc tcgacggcgg cctggatcag gttggccgcc tggtcccagt ccgagatgtc
3988081 cgacccgtcg gcgacggctt ggccaccggc cgcaaggatc tcgtcgacca cgtcttgggc
3988141 tgcgctgccg ccgcttgccg gcgaaccgtc caggcccaca ccgatatcgt tgaccaccac
3988201 gcgcgcaccc tcggccgcga aggccaacgc atgtgcgcgg ccgatgccgc cacccgctcc
3988261 ggtgacgatg accacccggc cgtcgaccaa gcccatgacc ccattgctcc tttgctcgtc
3988321 acttgttggc actcgaggcg cccaggtacg gcggcggctc accgccgccg tgcacctcga
3988381 gcgtcgcccc gctgatatat gacgccgcat cggacgccaa aaacgctgca gcccaaccaa
3988441 tgtcggcagg tcgtgccagc cggcccaacg gcaccgtggc ggcgacgcga gcgatcgact
3988501 cggcatcacc gtagaacagt tcggaccgtt cggtttccac catgccgacc accacggcgt
3988561 tgacccgaac cttgggtgcc cattccaccg ccagcgtggt ggtcaggttt tccaggcctg
3988621 ccttggccgc gccataggcc gccgtgccgg gagtgggacg gcgaccgctg acgctacaga
3988681 tgtttacgat cgacccaccg ttgggctgcg cttgcatcag cacgttggcg tgctgggaaa
3988741 ccagcagcgg tgcaagcaca ttgagctcga cgatctttcg gtggaagttg tgtgtcgcct
3988801 cggcggccag cgcgtatggc gagccgcccg cgttgttgac cagcatgtcg agtcggccgt
3988861 gccgctcccc gatctcaccg accaggcgct tgaccgagtc ctcgtcccgg atgtcgcagc
3988921 ggtggaactc atacggttgg ccgtcgaccg ctcgtcgcgc gcaggtgatc acggtcgcgc
3988981 cctgttcggc gaataccgag ctgatgcccg cgcctacccc gcggacaccg ccggtgacca
3989041 aaaccacccg cccggccagc ccgaaattga tggcgtcggc tgcctcggcg agagtcactg
3989101 tgctagcgta ccaagcaagt gcttgcttag gtagcgaacc cgcaggagtg caatgccgat
3989161 cacctccacc acgcccgaac cgggcatcgt cgcggtcacc gtcgactacc cgccggtcaa
3989221 cgccatcccg tcgaaagcgt ggttcgacct ggccgacgcg gtgacggccg cgggcgccaa
3989281 ctccgacacc cgcgcggtga tcctgcgggc cgaggggcgc ggcttcaacg ccggggtgga
3989341 catcaaagag atgcaacgaa ccgaaggttt cacggcgctg atcgacgcca accgcggctg
3989401 cttcgccgca ttccgcgccg tctacgagtg cgcggtgccg gtgatcgccg ccgtgaacgg
3989461 attctgcgtg ggcggcggca tcggcctggt cggcaactcc gacgtcatcg tggcctccga
3989521 ggacgccacc ttcggcctgc ccgaggtgga acggggcgcg ctgggcgcgg ccacgcacct
3989581 ctcgcggctg gtgccccagc acctgatgcg acggctgttc tttacggcgg ccaccgtgga
3989641 cgcggccacc ttgcagcact tcggctcggt gcacgaggtg gtgtcccgcg atcagctgga
3989701 cgaggccgct ttgcgggtgg cccgcgacat cgccgccaaa gacacccggg tcatccgcgc
3989761 cgccaaggag gcgctgaact tcatcgacgt gcaacgggtc aatgcgagtt accggatgga
3989821 gcaaggtttt accttcgagc tcaacctcgc cggagtcgcc gacgagcacc gcgacgcctt
3989881 tgtgaagaag tcatagtgcc cgataaacga accgctcttg acgacgccgt cgcgcaattg
3989941 cgcagcggca tgaccatcgg catcgccggc tggggctcgc ggcgcaagcc catggcgttc
3990001 gtgcgggcca tcctgcgctc ggatgtcacc gatttgacgg tggtcaccta cggcgggccg
3990061 gacctggggc tgctgtgctc ggcgggcaag gtcaagcggg tctactacgg gttcgtctcg
3990121 ctggactcgc cgccgttcta cgacccgtgg ttcgcgcacg cccgcaccag cggcgcgatc
3990181 gaggcccggg agatggacga gggcatgctg cgctgcggtt tgcaggccgc ggcacaacgg
3990241 ctgccgttcc tgcctattcg cgccgggctg ggcagctcgg taccacagtt ctgggcaggc
3990301 gagctgcaga cggtcacgtc gccgtatccg gcgcctggcg gcgggtacga gacactgatc
3990361 gccatgccgg cactgcgcct ggatgccgcc ttcgcccact tgaatctcgg tgacagccac
3990421 ggcaatgcgg cctacaccgg catcgacccc tacttcgacg atctcttctt gatggccgcc
3990481 gagcggcgct ttctgtcggt ggagcgcatc gtcgccaccg aggaactggt caaatcggtg
3990541 ccgccgcagg cgctgttggt caaccggatg atggtcgacg ccatcgtgga agcacccggc
3990601 ggcgcccact tcaccaccgc cgcaccggac tacgggcgcg acgagcagtt ccagcggcac
3990661 tacgccgaag cggcgtcgac acaggtgggt tggcagcagt tcgtgcacac ctacctatcc
3990721 ggcaccgaag cggactacca ggccgcggtg cacaactttg gagcatcacg gtgagcaccc
3990781 gagccgaagt gtgtgccgtc gcctgcgccg agttgttccg cgatgcaggc gaaatcatga
3990841 tcagccccat gaccaacatg gcctcggtag gggcgcggct ggcgcggctc accttcgcgc
3990901 cggacattct gctgaccgac ggcgaggctc agctgctcgc ggacacaccg gcattgggca
3990961 agacgggcgc cccaaacagg attgaggggt ggatgccgtt cggccgggtt ttcgaaaccc
3991021 tggcctgggg gcgccggcac gtggtgatgg gcgccaatca ggtcgaccgc tatggcaatc
3991081 agaacatctc ggcgttcggg ccgctgcagc ggccgacccg gcagatgttc ggcgtccgcg
3991141 gctcgccggg caacaccatc aaccacgcca ccagttactg ggtgggcaac cactgcaagc
3991201 gggtctttgt cgaggccgtc gatgtggtct ccggcatcgg ctacgacaag gtggatccgg
3991261 acaatccggc cttccggttc gtcaacgtct accgggtggt gtccaaccta ggcgtgttcg
3991321 acttcggcgg ccccgaccac tccatgcggg cggtatccct acaccccggg gtgacgcccg
3991381 gcgacgtccg cgacgccacc tcgttcgagg tgcatgacct cgacgcggcc gagcagacca
3991441 ggctgcccac cgacgacgaa ctgcacctga tccgcgcggt aatcgatccg aagtcgttgc
3991501 gggacaggga gatacgatca tgattgttcc gcctcctctc ccccgcaagc gggaggtgcg
3991561 cccacatcgc ttcgtcccct gcaagcgggt ggtaccccca ctgcattgtc ggcggtggct
3991621 atgaggctgc gtacgccgct gaccgagctc atcggcatcg agcacccggt ggtgcagacc
3991681 gggatgggct gggtggccgg tgcccggctg gtgtcggcca ccgccaacgc gggcgggctg
3991741 ggcatcttgg cctcggccac catgacgctg gacgagctgg cggcggcgat cacaaaggtc
3991801 aaggccgtca ccgacaagcc attcggggtg aacatccgcg ccgacgcagc cgacgcgggc
3991861 gaccgcgtcg agttgatgat ccgcgagggg gtgcgggtgg cctcgttcgc gttggcaccc
3991921 aaacagcagc tgatcgcccg gctcaaagaa gccggcgcgg tggtcatacc gtcgatcggc
3991981 gcggccaaac atgcgcgcaa ggtggcggcc tggggcgccg acgcgatgat cgtgcagggc
3992041 ggcgagggcg gcggccacac cgggccggtc gccaccacgc tgctgttgcc gtcggtgctg
3992101 gacgccgtgg cgggcaccgg catcccggtg atcgccgccg gcggcttctt cgacgggcgc
3992161 gggctagccg cggcgttgtg ctacggcgcc gccggggtgg ccatgggcac ccggtttctg
3992221 ctcacctcgg attccaccgt gcccgacgcg gtcaaacggc gttacctgca ggccggcttg
3992281 gacggcaccg tggtcaccac ccgcgtcgac gggatgccgc accgggtgct gcgcaccgag
3992341 ctggtcgaga agctggaaag cggctcgcgg gcacgaggtt tcgcggccgc gctgcgcaat
3992401 gccggcaagt ttagacggat gtcgcagatg acctggcggt cgatgatccg agacggcctg
3992461 accatgcgcc acggcaagga attgacctgg tcacaggtgc tgatggcggc aaacaccccg
3992521 atgctgctca aagccggcct ggtcgacggc aacaccgagg ccggggtgct ggcatcgggc
3992581 caggtagcgg gcattcttga cgacctaccg tcgtgcaaag agctgatcga gtcgatcgtg
3992641 cttgacgcca tcacacattt acaaaccgca tctgcgctgg tggagtgact gacgcgtgtc
3992701 aagcagagta cgctatcgca gctatgtcga ccgtcgagat ggaccaggcg gctccagagt
3992761 ccgccgcgca ccaccctctg ccggaccccg gtgagtcggt ccccagactc gcgctgccca
3992821 cgatcgggat cttcctggcc acgctcaccg cgttcgtcgg ttctacgacc gcttacatca
3992881 gcggatggat cccgttctgg gtgacgatcc ccgtcaacgc cgcggtcacg ttcgtgatgt
3992941 tcaccgtcgt gcatgacgca tcgcattacg cgatcagctc catccggtgg gtgaacgggc
3993001 tgttcgggcg gctggcgtgg cttttcgtcg ggccggtggt cgcgttcccg gccttcgggt
3993061 acatccacat ccagcaccac cgccattcca acgacgacga gcaagacccg gacaccttcg
3993121 cctcacacgg ctcgctgtgg gtgctgccgt tgcgctggtc gatggtcgag tacttctaca
3993181 tcaagtacta cctgcctcgc ggccgcagcc ggccggtcat cgaggtcgcc gagacgctgg
3993241 tgatgatgac cctgttcctg accggcctga tcgtcgccat cgtcaccggc aacttctgga
3993301 cgctggcgat cgtcttcctg atcccgcaac gtatcggcct taccgtgctg gcctggtggt
3993361 tcgactggct gccccaccac ggtctggagg acacccagcg cagcaaccgc taccgcgcga
3993421 cccgcaaccg ggttggcgcc gagtggctgt tcaccccggt gctgctgtcg cagaactacc
3993481 acttggtgca ccacctgcac ccgtcggtgc cgttctaccg gtacctgcgc acctggcggc
3993541 gcaacgagga ggcgtatctg gaacgcaacg ccgcgatctc cacggtcttt ggccagcaac
3993601 tgaatccgga cgagtaccgg cagtggaagg agctcaacgg ccggctcgcg cgactgctgc
3993661 cggtgcggat gccggcccgc tccagctcgc cgcacgcggt gctgcaccgc atcccggtcg
3993721 cgtcggtgga tcccatcacc gccgatgcca ccctggtgac tttcgcggtg ccggaagcat
3993781 tgcgggacgc gttccgattc gagccgggcc agcacgtgac ggtgcgcacc gacctgggcg
3993841 gccaaggcat ccggcgcaac tactcgatct gcgccccggc cacccgcgcc cagctgcgca
3993901 tcgccgtcaa acacattccc ggcggggcgt tttcgacgtt cgtggccaac gaactgaagg
3993961 ccggcgacgt gctcgagctg atgacaccga ccggccggtt cggcaccccg ctggatccgt
3994021 tgcaccgcaa gcactatgtg ggcctggtgg ccggcagcgg gatcaccccg gtgctgtcca
3994081 tcctggcgac cacgctggag atcgagaccg aaagccgatt cacgctgatc tacggcaacc
3994141 gcaccaagga atcgacgatg tttcgggccg agctggatcg tctggagtcg cgctatgccg
3994201 accggctgga aatcctgcac gtgctctcca gcgagccgct gcacaccccg gagctgcgcg
3994261 ggcgcatcga ccgagacaaa ctcaccaggt ggctgacgag taccctgcgg ccggccggtg
3994321 tggacgaatg gttcatctgc ggcccgctcg ccatggccac cgcggtgcgc gagaccctga
3994381 tcgagcacgg cgtggactcc gagcgcattc acctggagtt gttctacggg ttcgacacgc
3994441 ccccggcgac ccgtccctcc tatgcgggag ccaccgtcac cttcacgctg tccgggcagc
3994501 gggcgatatt cgatctggtg cccggcgact cgattctgga aggggcgctg gggctgcgca
3994561 gcgatgcgcc gtatgcgtgc atgggcggcg catgcggcac ctgccgagcc aaactgatcg
3994621 agggcaacgt cgagatggac cacaacttcg ccctccggaa ggcggagctg gatgccggct
3994681 acatcctgac ctgccagtca cacccgacga caccattcgt cgccgtcgac tacgacgcct
3994741 aggttcgtgg cgccgcccca tacttgcgcc gactgtgaat ctgacgacgc gacacgccga
3994801 ttcgccgtcg tgtggttcac tctcggcgct catgggcgcc atcccgccgc ccgcatcgcg
3994861 gcatcgacgc ggccaacgaa cgtgccccgg cggtaccaga gcagctcact ggtgaccctg
3994921 atgatcgtcc agcccagatc cagcaacgcg gtggaccgct cgatgtcccg agcccgctgc
3994981 gccgggtctg tccaatgctg tggcccgtca tactcgacac cgactcgcaa ttgctcgtag
3995041 cccaggtcga tgcgggcgac gaagtccccg tagtcgtcaa acactctgat ctgtgtttgc
3995101 ggcttcggca gaccggcatc gatcaacacc aatcgggtcc acgtctcctg tggggattcc
3995161 gcacccccgt cgatcagcgg cagcaccgca cggaggcgga ccaggccgcg cgcaccggta
3995221 tgttcggcaa tgacggcctg cacgtcggcg accttgacat cggtcgaatt cgccaacgcg
3995281 tccagccgtt gaacggcctg cagccgcgag ggtgtgcgcc gcccgatatc gaaggcggtg
3995341 cgcgccgggg tggttaccgc gacaccgtca accgcaaccg tctcgtgcgg cgccaatcga
3995401 tccgtgtgca cgacgatgcg cggcggaggc tttcgattgg cgtgcactaa ctctgcgtca
3995461 agcgctgggt ttacccactt cgcgccaagc agcgccgccg ccgaattgcc ggccacgacg
3995521 gcgcggcgcc gcgaccacag ccacgccgcg tgggcgcgct ggcgcgccgt cagctccaca
3995581 ccggccgggg cgtagacgcc cgggtagact ggctcgtaga gctgtctcat ggcccgctcc
3995641 ggaatggcct ttgcggccaa cacttccgag cccaggacgg gccatggaag ttcgtccatg
3995701 gccacatcct ggcatcaccc accgacaccc cgccgacagt gaatcgcacg acgcgacacg
3995761 ccgacgaccc gtcgtgagat tcaccctcgg cgccaacgaa ggcctacagc cgctcgataa
3995821 tggtgacgtt ggcggtgccg ccgccctcgc acatggtctg cagcccgtag cggccaccga
3995881 tgcgctccag ctcgcccagc atggtggtga acagtttggc gccggtggcg cctagcggat
3995941 gccccagcgc gatcgcgccg ccgttggggt tgaccttcgc cgggtcggcc ttgatttcct
3996001 tgagccaggc cataactacc ggcgcgaacg cctcgttgat ctcgacggtg tcgatgtcgt
3996061 cgatggcaag cccggtcttg tccagcgcgt accgggtggc ggggatgggt ccggtcagca
3996121 tgaataccgg gtcggcggcg cgcgcactga tgtggtggat gcgggcacgg ggcctaagtc
3996181 catggtcttt gacggcccgc tcggaggcca gcaacactgc actggcgccg tcggagatct
3996241 gactggccat cgccgccgtc agccggccgc cctcgaccag cggctgcaag ccggccatct
3996301 tctccagcga cgactcccgc gggccctcat caacccggaa cggcccggat tcggtttcca
3996361 cagtgatgat ttcgttttcg aagtggccgg cgcggatcgc cgcgaacgcg cgttcgtggc
3996421 tggtcagcga gtaccgctcc atctcttcac gggacaggtt ccacttctcg gcgatcagct
3996481 ccgagccacg gaactgtgaa atctcctggt cgccataccg gtgtaaccat tgcttggatt
3996541 cgttggtcgg cgaggtgaac ccgaactgtt cgcccacggt catcgccgac gagatcggga
3996601 tctggctcat gttctgcacg ccgccggcca cgatgacatc cgccgtgccg gacatgatcg
3996661 cctgcgcgcc aaaggaaatc gcctgctggc tggatccgca ctggcggtcc acggtgacac
3996721 cggggacctc ttcgggatag ccggcggcca gccacgacag tcgggcgatg ttgcccgcct
3996781 gtccgccgat ggcgtcgaca catccggcga tcacgtcgtc gacggcggcg gggtcgatgt
3996841 cggtccggtc cagcagtccg cgccaggcca gggcacccag gtcgacggga tggataccgg
3996901 ccagtgcgcc gccccgcttg ccgaccgcgg tccgtacggc gtcgatgacg tacgcctctg
3996961 tcataaccgc tcctctcccg ttgccagtga gtggtacccc caccgcatcg tcgtcgacac
3997021 ggggcatttc agactccctc tttggtgatc ccgccaagca cgatggctag gtattgctgg
3997081 cccacctgct gggcggtgag cggcccaccg ggtcgatacc agcgcaccga cacccaggtg
3997141 gtgtcacgga tgaatcggta gaccaggtcg acgtctaggt cgggccggaa gtagccctct
3997201 tcgatgccct ggttgagcac gtccacccac atcttgcgct gctgcttgtt acggtcctcg
3997261 atgtaggaaa acctgggttg cgacgccagc cgttgcgctt catcctggta gatcaccact
3997321 tgcgcgtgat gatgctcgat cgcctcaaac gacgccatga acaggccctg cagccgctcc
3997381 agcggattgg ccgtgctatc cacgatgtcg cggtaacggg cgaagagcca atcgaggaaa
3997441 ccgcgtaaca gctcatcgac catctcctct ttggaggcga aatggtgata caggctgccg
3997501 gataggatgc cggcgccgtc ggcgatatcg cgcacggtgg tggcgcgcag tccgcgctcg
3997561 gcgaacatcg ccgccgcgag ctccagcaac tcgcctcgcc ggctattgac ctgaccggcc
3997621 actcgatcca tccgaccaga ctatcaacca agcgcttgct cggccagctg cgacctcgat
3997681 ggggtgggaa tccgggaatt cggtacgagg gatgcgccct tcgctcaccg gggcattaga
3997741 tgcgacgttg ctggcgctgg atggacgcct tgcccgcaca gcccggccca ggtgcaggat
3997801 cgaggggctt ggtacctgat cacgggagac atctggggta tcggcggaga gtgcctagcg
3997861 ttctgggcat tctggcggat tgcgcatatt cttccgcgcg tcgtcatagc ctaatcggac
3997921 tacgcggatc gtgccgatca ccctggtgcg gcggcggcgc cagtaacgag gaggtcaaca
3997981 tggctcattt ttcggtgttg ccgccggaga tcaactcgtt gcggatgtac ctgggtgccg
3998041 gttcggcgcc gatgcttcag gcggcggcgg cctgggacgg gctggccgcg gagttgggaa
3998101 ccgccgcgtc gtcgttctcc tcggtgacca cggggttaac cgggcaggcg tggcagggcc
3998161 cggcgtcggc ggcgatggcc gccgcggcgg cgccgtatgc gggctttttg accacagcct
3998221 cggctcaagc ccagctggct gccgggcagg ctaaggcggt ggccagcgtg ttcgaggccg
3998281 ccaaggccgc gatcgtgcct ccggccgcgg tggcggccaa ccgtgaggcg ttcttggcgt
3998341 tgattcggtc gaattggctg gggctcaacg cgccgtggat cgccgccgtt gaaagccttt
3998401 acgaggaata ctgggccgct gatgtggcgg cgatgaccgg ctatcacgcc ggggcctcgc
3998461 aggccgccgc gcagttgccg ttgccggccg gcctgcaaca gttcctcaac accctgccca
3998521 atctgggcat cggcaaccag ggcaacgcca acctcggcgg cggcaacacc ggcagcggca
3998581 acatcggcaa cggaaacaaa ggcagctcca acctcggcgg cggcaacatc ggcaataaca
3998641 acatcggcag cggcaaccga ggcagcgaca acttcggcgc cggcaacgtc ggcaccggaa
3998701 acatcggctt cggcaaccag ggccccatag acgttaacct cttggcgacg ccgggccaga
3998761 acaacgtggg cctgggcaac atcggcaaca acaacatggg cttcggcaac accggcgacg
3998821 ccaacaccgg cggcggcaac accggcaacg gcaacatcgg tggcggcaac accggcaaca
3998881 acaacttcgg cttcggcaac accggcaaca acaacatcgg aatcgggctc accggcaaca
3998941 atcagatggg catcaacctg gccgggctgc tgaactccgg cagcggcaat atcggcatcg
3999001 gcaactccgg caccaacaac atcggcttgt tcaactccgg cagcggcaac atcggcgtct
3999061 tcaacaccgg agccaatacc ctggtgcctg gcgacctcaa caacctgggc gtcgggaatt
3999121 ccggcaacgc caacatcggc ttcgggaacg cgggcgttct caacaccggc ttcgggaacg
3999181 cgagcatcct caacaccggc ttggggaacg cgggtgaatt aaacaccggc ttcggaaacg
3999241 cgggcttcgt caacacgggg tttgacaact ccggcaacgt caacaccggc aatgggaact
3999301 cgggcaacat caacaccggc tcgtggaatg cgggcaatgt gaacaccggt ttcgggatca
3999361 ttaccgacag cggcctgacc aactcgggct tcggcaacac cggcaccgac gtctcgggct
3999421 tcttcaacac ccccaccggc cccttagccg tcgacgtctc cgggttcttc aacacggcca
3999481 gcgggggcac tgtcatcaac ggccagacct cgggcattgg caacatcggc gtcccgggca
3999541 ccctctttgg ctccgtccgg agcggcttga acacgggcct gtttaacatg ggcaccgcca
3999601 tatcggggtt gttcaacctg cgccagctgt tggggtagcg cgacactcac gggtgctggc
3999661 aggataccga aatcacctca ccagtcaggt aactcgagta gtcgctggcc agaaacgcga
3999721 tggtggccgc cacctcccag ggctcggcgg cccggccgaa cgcctcgccg gccgccagcc
3999781 ggtccagcag ctcggccgag gcggtcttgt ccaggaactt gtgccgggcg atgctgggcg
3999841 agacggcgtt gatccgcacc ccatactcgg cggcttcgat tgcgctgcac cgggtcaacg
3999901 ccatcacccc ggccttggcg gcggcatagt gcgactgcga atgctgggcc cgccagccca
3999961 gcacgctggc gttgttgacg atcaccccgc catgcggcgc gtcgcggaag tagcgcaatg
4000021 cggcccgggt ggcccggaac accgacgtca ggctcacgtc taacacgcgg tcccactcgt
4000081 cgtcggtcat gtcggccacc ggcgtctgcc cgcccagccc ggcgttgttg accagcacgt
4000141 cgagccggcc catccgggcg gtggtcgagt cgatcagcgc gtcgacctgg gcggtggacg
4000201 tcacgtcgca caccacatgc tccacccggc ccagccccag cgcagacaac tcggcggccg
4000261 tctcccccag ccgtcgttca tggtggtccg agatcaccac gtcggcgccc tccgccaagg
4000321 ctcgccgcgc ggtggccgaa ccgatgccgg tgcccgcagc cgccgtcacg acgaccacct
4000381 tgccatccag aagtccatgt ccggcaatct ctttcggcgc tacggacagg ttcatccctt
4000441 ggcctcccgg ggcagaccga gcacccgctc ggcgatgatg ttgcgctgga tctcgttgga
4000501 tcctccgtag atggtgtcgg cgcgggtgaa tagatatagc cgctgccact cgtcgaactc
4000561 gccgtcgggc atggtcattc cgggtttacc gatcacgtcc atggccagct cacccaggtt
4000621 gcgatgccag ttggcccaca acaactttga cacattgtcc tggccgggct gctcaacggc
4000681 tggcccttcc atggtggcca aagcatagga gcgcatggcg cgcagcccgg tccacgcccg
4000741 ggtcagccgc tcccggatca gcgggtcatc cgcggcggcg gtgcgccgcg ccagctcgac
4000801 cagattggaa agctcacggg cgtagacgat ctgctgaccc agcgtcgaga cgccgcgctc
4000861 gaaggtcagc gtcgccatcg cgacccgcca gccgtcgccc ggtgcgccga ccaccaggtc
4000921 ggcgtcggtg cgggcgtcgt cgaagaacac ctcgttgaac tccgcggtgc cggtgatctg
4000981 cacgatcggc cggatctgca cgccgggctg gtccagcggc accagcagat acgacaggcc
4001041 ggcgtggcgc tgcgagccct tctcggtgcg tgcgagcaca aagcaccatt gcgacaggtg
4001101 cgccagcgac gtccacacct tctggccgtt tatcacccac tggtcgccgt cgagttctgc
4001161 ggtggtcgca acgctggcca ggtcgctgcc agcgccgggc tccgaatatc cctgacacca
4001221 cagctcggtg acgtcgcgga tgcgcggcag gaagcgccgc tgctgctgcg gcgttccgaa
4001281 cgcgatcagc gtcggaccca gcagttcctc gccgaagtgg ttgaccttgt ccggcgcgtc
4001341 ggcgcgggcg tattcctcgt agaacgccac ccggtgcgcg gtcgagagcc cccgcccgcc
4001401 gtgttcttcc ggccagccca ggcaggtcag ccccgcggcg gccaggcgct gattccacgc
4001461 ccggcgttcc tcgaacgctt cgtgctcgcg ccccggcccg ccgaggccct taagtgccgc
4001521 gaattcgccg gccagattgt cggcgagcca accgcggacc tgcgcccgga actcctcgac
4001581 gtcctgcatg ccctgtaggc taacctacca agcacttgct ttgttaggag cgtccgttga
4001641 taaacgatct gcgcaccgtg cccgcggcgc tggatcgtct cgtgcgccag ctacccgacc
4001701 acacggcgtt gatcgccgag gaccggcgtt tcacgtcgac cgagctgcgc gacgcggtct
4001761 acggcgccgc ggcggcgctg atcgccctcg gtgtcgaacc cgcagaccgg gtggccatct
4001821 ggtcgccgaa cacctggcac tgggtggtgg cctgcctggc gatccaccac gccggcgccg
4001881 cggtggtgcc gttgaacacc cgctacaccg ccacagaagc caccgacatc ttggaccgag
4001941 ccggcgcgcc ggtgctgttc gcggcgggcc tcttcctggg cgccgaccgg gcggccggcc
4002001 tggaccgggc cgcgctgccc gcgttgcggc acgtcgtgcg ggtgccggtc gaagccgacg
4002061 acgggacctg ggacgagttc atcgccacgg gtgccggggc cctggatgcc gtcgcagccc
4002121 gtgccgccgc cgtcgcaccc caggacgtca gcgacatcct gttcacctcc ggcaccaccg
4002181 gccgcagcaa aggcgtgctg tgcgcgcacc ggcagtcgct gtcggcctcg gcatcctggg
4002241 ccgccaacgg gaagatcacc agcgacgacc gctacctgtg catcaacccg ttcttccaca
4002301 acttcggcta caaggccggc atcctggcct gcctgcagac cggtgccacg ctgatcccgc
4002361 acgtgacgtt cgatccgctg cacgcgctgc gggccatcga gcgccaccgc atcaccgtgt
4002421 tgccgggccc tccgaccatc taccagagcc tgctggatca cccggcccgc aaagacttcg
4002481 acctgagctc gctgcggttc gcggtcaccg gtgcggccac cgtgccggtg gtgctggtgg
4002541 agcgcatgca gtccgaactt gacatcgaca tcgtgctgac cgcctacggg ttgaccgagg
4002601 ccaacgggat ggggacgatg tgccgccccg aggacgacgc ggtgaccgtt gcgacgacgt
4002661 gcgggcggcc gttcgccgac tttgagttgc gcattgcgga cgacggggaa gtgttgctgc
4002721 gcgggccgaa cgtcatggtg ggctatctgg acgacacgga ggcgaccgcg gccgccatcg
4002781 acgccgacgg ctggctgcac accggcgaca tcggtgccgt cgaccaggcg ggcaacctgc
4002841 gcatcaccga ccgcctgaag gacatgtaca tctgcggcgg attcaacgtc tatcccgccg
4002901 aggtcgagca ggtgctggcc cggatggacg gcgtcgcgga cgccgcggtg atcggcgttc
4002961 ccgaccagcg gctgggcgag gtcggccggg cgttcgtggt ggcgcgcccc ggcacgggcc
4003021 tcgacgaggc atcggtgatc gcttacaccc gtgaacattt ggcgaacttc aagacacccc
4003081 ggtcggtgcg gttcgtcgac gtactgccgc gcaacgccgc cggtaaggtg agcaaaccac
4003141 aactgcgaga gctgggctag atggacctga atttcgacga cgagaccctg gcctttcagg
4003201 ccgaggtgcg cgagttcctc gccgccaatg ccgcatcgat cccgacgaag tcctacgaca
4003261 atgcggaagg ctttgcgcaa caccgttatt gggaccgagt actgttcgac gcgggcctgt
4003321 cggtgatcac ctggccggct aagtatggtg gccgggacgc gccgctgctg cactggatcg
4003381 tgttcgagga ggagtacttt cgcgccggcg ccccgggccg ggccagcgcc aacggcacct
4003441 cgatgctggc gccgacgctg ttcgcgcacg gcacagccga acagcttgac cggatcctgc
4003501 cgaaaatggc tagcggcgaa cagatctggg cgcaggcctg gtcggagccg gaatccggca
4003561 gcgacctggc gtcgctgcgc tccaccgcga gcaaggtcga cggcggctgg ctactcaacg
4003621 ggcagaagat ctggagctcg cgggcgccgt tcgccgacat gggttttggg ctgttccgct
4003681 ccgatcccgc ggtcgaacgg caccgcgggc tcacgtattt catgttcgac ctgaaagcca
4003741 agggtgttac cgtgcgccca atcgcccaac tgggcggcga caccggtttc ggtgagatct
4003801 ttctcgacga cgtgttcgtc cccgaccggg atgtgattgg ggcaccgaac gacggatggc
4003861 gcgcggccat gagcacgtca agcaacgagc gcggcatgtc gctgcgcagc ccagcccgct
4003921 tcctggcctc cgccgaacgg ctggtccagc tgtggaagga ccgcggctcg cccccggagt
4003981 tcgccgaccg ggtcgccgac gcctggatca aggcgcaggc ctaccggctg cagaccttcg
4004041 gcacggtgac caggctggcc gccggtggcg aactgggggc ggaatcgtcg gtgaccaagg
4004101 tgttctggtc cgagctggac gtgcacttgc atcagaccgc gctcgacctg cgcggcgccg
4004161 atggggagct ggccggcccg tggaccgagg ggttgctgtt cgccctgggc ggcccgatct
4004221 atgccgggac caacgaaatc cagcgcaaca tcattgccga acggctgctg ggcctgccac
4004281 gcgagaagac gtgaccatgg aattcgcact caacgaacag cagcgcgact tcgcggccag
4004341 catcgacgcg gcgctcggcg ccgccgacct gcccggcgtc gtccgtgctt gggctgccgg
4004401 tgatgtggcg cccggccgca aggtgtggca gcagttggcc aacctgggcg tcaccgcgtt
4004461 gggcgtagcg gagaagttcg acggactggg tgccagtccg gtcgatctgg ttgtcgcgct
4004521 cgaacgtctc gggcgctggt gcgtgcccgg cccggtcacc gaatccattg ccgtggcacc
4004581 gattctgctg gctcatgatg atcaggctga acgcagccat gggctagctt ccggtgagct
4004641 catcgccacc gtggccatgc cgccgcgggt tccgcgcgcc gtcgacgccg acaccgccgg
4004701 gctggtactg ctcgcgggcg atggcagcgt caccgaaggg acgccgggtg attgccaccg
4004761 gtccgtcgac cccagccggc ggctgtatga ggtggcggca tccggccagg cctggcgggc
4004821 cccgaaagac gtagtggcgc gcgcctatga gttcggggcg ctggccaccg ccgcacaact
4004881 ggtcggcgcc gggcaggcgc tgctggaggc cgccgtcaac tacgccaaac agcgcacgca
4004941 gttcggccgg gcgatcggct cgtatcaggc catcaagcac aaactcgccg acgtgcacat
4005001 tgcgatcgag ctggcctgcc ccctggttta cggcgcggcc gtgtcactcg agccgcgcga
4005061 tgtcagcgcc gccaaagccg ccgcgagcga ggcggctctg ctggcggcac gctgggcgtt
4005121 gcagacccac ggcgccatcg ggttcacctg cgagcatgac ctgtcgctgt ggttgttgcg
4005181 ggtgcaggcg ttgcactcgg cctggggtac gccgcaggag catcggcggc gtgtgctgga
4005241 ggcgctatga ccccccctga agaacggcag atgctacggg aaaccgtcgc ctccctggtg
4005301 gctaagcatg ccggcccggc ggcggtgcgc gcagcgatgg cctccgaccg cggctacgac
4005361 gaatcgctgt ggcggctgct atgtgagcag gtcggtgccg ccgcgctggt cattccggag
4005421 gagctgggcg gcgcgggcgg tgaactcgcc gatgccgcga tcgtcgtgca ggagctgggc
4005481 cgggcgctgg tgccttctcc gctgctgggc accacgctgg cggagctggc gctgctggcc
4005541 gcagctaagc cggatgcgca agcactcacg gagcttgccc aaggcagcgc gatcggcgcg
4005601 ctggtgttgg accccgacta cgtggtcaac ggcgacatcg ccgatatcgt cgtcgccgcc
4005661 accagcgggc agctgaccag gtggactcgc tttagcgcgc agcccgtcgc caccatggac
4005721 cccactcgcc ggctggcccg cctgcaatcc gaagagaccg agccgctgtg ccccgatccc
4005781 ggaatcgccg acaccgcagc aatcctgttg gcggccgagc agatcggcgc cgccgaacgc
4005841 tgcctgcagc tgaccgtcga atacgccaag agccgagtgc aattcggccg cccgatcggc
4005901 agtttccagg ccctcaagca tcggatggcc gacctgtatg tgaccatcgc cgcggcccgg
4005961 gccgtcgtcg ccgacgcctg ccacgcgccc acacccacca acgccgccac cgcgcggctg
4006021 gccgccagcg aggcgttgag caccgcggcg gccgagggca tccaactgca cggcggcatc
4006081 gcgatcacct gggaacacga catgcacctg tatttcaaac gagcgcacgg cagtgcacaa
4006141 ttgctcgagt cgccacgaga ggtgctgcgc cgtttggaat ctgaggtgtg ggagtcgccg
4006201 tgacggatcg tgtcgccctg cgtgccggcg ttcccccgtt ctacgtgatg gacgtctggt
4006261 tggcggccgc ggagcgccag cgcacccatg gggatctggt gaatctttcg gcgggccaac
4006321 ccagtgcggg cgctccggaa ccggtgcgtg cggccgcggc cgccgccctg catctcaacc
4006381 agttgggata ctcggtggcg ctgggtattc cggagctgcg cgacgctatc gccgcggatt
4006441 accaacgccg gcatggcatc accgtcgaac ccgatgcggt ggtgatcacc acgggctcct
4006501 cgggcggctt tctgctcgcg tttctggcgt gcttcgacgc cggtgatcgg gtcgcgatgg
4006561 ccagtcccgg ctacccgtgc taccggaata tcctgtcagc gctgggatgt gaggtcgtgg
4006621 agatcccgtg cggaccgcag acccgattcc aaccgaccgc gcagatgctg gccgagatcg
4006681 acccaccgct gcgcggtgtc gtcgtcgcca gcccggccaa cccgaccgga accgtcatcc
4006741 cgcccgaaga actggcggcc atcgcgtcgt ggtgtgacgc atcggatgtc cggttgatca
4006801 gtgatgaggt ctaccacggc ctggtgtacc agggggcacc gcaaaccagc tgcgcctggc
4006861 agacgtcgcg aaacgcggtg gtagtcaaca gcttttccaa gtattacgcg atgacgggct
4006921 ggcggctggg ctggctgctg gtgccgacgg tgctgcgccg cgcggtggac tgcctgaccg
4006981 gcaacttcac catctgcccg ccggtcttgt cgcagatcgc cgcggtgtcc gcgttcaccc
4007041 cggaggcgac cgccgaggcc gacggcaacc tggccagcta cgcgatcaac cgctcgctgt
4007101 tgctggacgg tctgcgtcgc atcggcatcg accggctggc acccaccgac ggcgcattct
4007161 acgtctacgc cgacgtctcg gacttcacca gcgattcgct ggccttctgc tcaaagttgc
4007221 tggccgacac cggtgttgcg atcgcacccg gaatcgattt cgacaccgca cgggggggtt
4007281 cgtttgttcg gatatcgttt gccgggccaa gcggcgacat cgaagaagcc ttacggcgca
4007341 tcggctcctg gctgccgagc caatagctcg tcgatgcgcg tctcgagcgc gccgcgctcg
4007401 ccgatatctg ccacgttgat cccgaaccgt tcgctcaggg tgtcgacaac cgctgccgca
4007461 tcggcaaggc ggatcttctc ggtaccaccg gcacggtgaa cggcaaggtc gcggccagat
4007521 aggttccacc gggcgtcgtc ggtgatcacc gcggcggtca gtcccgtgac gaacttcgat
4007581 gccgggtgtg ttgaggcgta ccagctggcc actttcagat cgatctgcgg gcgggtctgg
4007641 gtggtgaatt cgtacagtgt ctgccatgtg tcccggacca tcgcctgcaa gacaaagccg
4007701 tcgacgcggt cctcgagccg ataaggttcg tgcgttgtcg gctggacggc gccggtttcg
4007761 aggcgaagcg gtgaggtcgg tgtttggccg ccgaatccga cgtcgacgag atagcatccg
4007821 cccgagccgg ggaacgtgac ccccagcagg gtgtgcgtct gcggcggcag gggcgcgtcc
4007881 ggcgcgagct tccagacgac gcgggcggcg aatcggcgca cccgatagcc gagttcggcc
4007941 agcacataac ccatcagccc gttgtgctca aagcagtacc cgcctcggcg ccgaagtacc
4008001 agcttgtcgg ccagcgcctg tggactgagg tcgtcgaccg gcacccccag cagcgggtcg
4008061 aggttctcga acggaatcgt tcgactgtgc acggtcacca gatcctgcag aacatccagg
4008121 gttggatcgg tagcgccgcg atagttgatg cgatcgaagt acgcggtcag atccagtgcc
4008181 atgttgccat tctgacctcg tcgccgcgtc ggaccgaccg cagggtattc gggcgttcgt
4008241 cgcgcagccg gccaactatg tcgcaccgat tgtggtttgc cacatgagtt tctgggtcga
4008301 cggcaaacaa agtgccctcg cagcgacacg tgtcggcggc tacggcaaac tgcccgctga
4008361 cactcaccca tccggtggct gctcgcgcca tctggccgaa tgcccggcgg gtcggaggat
4008421 cggcgccgga cacaacaacg catcatgatg cctgttactg atgctattgc cgacccacgg
4008481 caccggaggc ttgcaggccg gtgtcgactt ggacgacaag gaagccctcg ccgaactgat
4008541 cggcgacaat gctgctcctt gacgtaagcg tctgcatatt cgccatccgc gaggacagct
4008601 gccccaacca cgcgacatac cggacgtggc tcaccagact gcttaccggc gacggcgagc
4008661 agacgcaaaa tcgcccaaca cgcccgcaaa atgggcgatt ttgcgtctgc tcgcgccact
4008721 agagccaggt gtcctgggtg gtggtgatga ggaaagcctc caggtcgtcg cgccagtgcg
4008781 ccggcgtggt cttttccggc tcgatgccgg tgtagtcgcc gcgatagaac agcagcggcc
4008841 gcggcttgac cgccgggacc tctgacagtg actcgacggc accgaacacc acgaagtgat
4008901 cgccgccgtc gtgcaccgac gccaccgtgc agtcaatgta ggccagcgat ccctcgatga
4008961 tcggtgagcc tagttccgaa gggcgccaat cgataccggc gaacttgtcc ggctccttcg
4009021 agccgaatcg cgccgagacg tctttctgct tttcggtcag tacgttgacg cagaaccggc
4009081 cgctggcctc gatggcctgc caggaccgcg acaccttagt ggggcagaac agcaccaacg
4009141 gcggttccaa cgacagcgcc gcgaacgact ggcacgcaaa cccgacgggc acgtcgtcgt
4009201 gcacagtggt gatgacagtg atccccgtac agaactgacc gagcacggag cggaacgtgc
4009261 gtggatcgat ctgagccgac atcgtttgct ttcgagctag ccgcgagcgc ctacggtgaa
4009321 atcgtgaccc cataggctga ccgcagtact ctcccgggcg atccagtccc gatcgtcgac
4009381 ttgcctgccc tcacaaccga attcgatgtc gaagccaccg ggcgtcttca tgtagaacga
4009441 cagcatcagg tcgttgacat gccggcccag ggtggccgac atcggcacct tgcgccgcaa
4009501 cgcccggtcc aggcacaggc ccacgtcgtc ggcctgctcg acctcgacca tcaggtgcac
4009561 gatgccgctg gacgtcggca tcggcaggaa ggccaacgag tggtgacgcg ggttacagcc
4009621 gaagaaacgc agccaggctg gcggcccgtc ggcgggccgc cctaccatct gtggcggtag
4009681 ccgcatcgag tcacgcagcc gaaagccgag cacgtctcgg tagaaatgca acgcctcagc
4009741 atcgtcgcgg gtggacagca ccacatggcc cataccctgc tcaccggtga cgaacctgtg
4009801 cccatacggg ctgaccactc ggcggtgttc cagcgcggta ccgtggaaga cctccaggca
4009861 attgccggaa gggtcggcaa accggatcat ctcgtccacc cggcgatcgg ccagctcggc
4009921 ggcggtggcc tctttgtacg gcgtgccctc caaatccagg cggttccgga tttcctgcag
4009981 gccttcggca ttcgcgcatt cccaaccggc ctccaacagc ctgtcgtgct caccgggcac
4010041 gaccaccagc cgggccggaa agtcatccat ccgcagatac agggcccctt ctggggcccc
4010101 tttgccctcg accatgccca ggaccttcag tccatactcc cgccaggcag ccatgtcagt
4010161 ggcctcgatg cgcagatagc ccagcgaccg gatgctcatc tgccacctcc cagaaattca
4010221 atcgtcagct tgttgaactc gtcgaacttc tccacctgca cccaatgccc acactgcccg
4010281 aatacgtgca gctgcgcacg cggaatcgtt ttcaacgcaa ccagcgcgcc gtccagcggg
4010341 ttgacccggt cctcacgacc ccagatcagc aacaccggct ggcgcagccg atacacctcg
4010401 cgccacatca tgccggcctc gaagtcggct ccggcgaacg actttcccat cgcccgtgtt
4010461 gccgtcaacg actccggggt gctggccagc gcaaaccgct gatccaccaa ctcgggggtg
4010521 atcaggttct tgtcgtagac catgacccgc aggaacgcct cgaggttctc ccgggtgggc
4010581 gcaacggaga acttcgacag ccgtttgact ccctcggtcg ggtcgggcgc aaacaggttg
4010641 atactcaggc cccccgggcc catcagcact aaccgtcctg cccgggccgg gtagtccagc
4010701 gcaaaccgga ccgcggttcc cccgcccaac gagttgccca ccagcggtac ccgccccagc
4010761 cccagctgat cgaagagccc cttcagcgcc atcgcggcat agcgattgaa ctggccgtgc
4010821 tcggcccgct tgtcggaatg gccgtaaccg ggctggtcga cggccagcac atgaaagtgc
4010881 cgcgccagca ccgcgatatt acgcgagaag ttcgtccagc tcgccgcgcc gggcccaccg
4010941 ccgtgcagta gcaccaccgt ctggtcgttg cccacgccgg cctcgtggta gtgcagtttc
4011001 agcggcccgt cgacgtccac ttccgcaaag cgcgaggtgg attcgaacgt caattcctcg
4011061 gtagctgtca tttcgcctag accagctaga ccatggtgtc gccgggcggc aacccgaact
4011121 cgtggtttcc aaagatcacg tatgcccgct cggggtcgtt ggcggcgtgc acccgaccgg
4011181 cgtgcgcgtc gcgccagaac cgttgaatcg gagcctcatt ggacaacgcg gtggcaccgg
4011241 acgcctcgaa cagccggtcg atcgaggcga ttgagcgacc ggtggcgcgc acctggtcgc
4011301 ggcgcgcacg ggcgcgcagt tcgaacggaa tctccttgcc ggcagccagc agcgcgtatt
4011361 cgtcgctcac attaccgatc agttggcgcc acgcggcgtc gatgtcgctg gccgcctcgg
4011421 cgatacggac cttggcaaac gggtcgtctt tggccttttc cccggcgaac gccgcgcgca
4011481 cccgcttgcc ctggtgctcg acgtgcgcgg cgtaggcacc gtaggccatg ccgacaatcg
4011541 gcgccgaaat cgtagtggga tgcattgtgc cccatggcat tttatagaca ggtgcgctgt
4011601 tggtcgccag ccctcccgcg gtgtggtcgt tcatcgcctt gtacgacaag aaccggtgcc
4011661 ggggcacaaa gacatccttg accaccaggg tgttgctgcc ggtaccacgt aagccgacca
4011721 cgtaccacac gtccttgatc tcgtattcgc tgcgcgggat caggaaactg ccgaagtcca
4011781 ccggccggcc gtccttgatg accgggccgc cgacgaacgt ccagctggca tggtcgcagc
4011841 ccgaggacca gttccacgac ccgttgacca ggtagccacc gtcgaccacc acgcccgccc
4011901 ccatcggtgc gtacgaggac gagatccgcg tactcgggtc ctcgccccag acctcctctt
4011961 gggcccgttg gtcgaacagc gccagatgcc agttgtgcac gccgacgatt gagctcaccc
4012021 acccggtgga accacacacg ctcgccagtc gacgcgtcgc ctcgaagaac agcgcagggt
4012081 cgcactgcag tccgccccac tgctgcggct gcaacagggt gaagaagccg acgtcgtcga
4012141 gcgccttgac ggtctcgtcg ggcagccgcc gcagatcctc cgtggcctgg gcgcgatccc
4012201 gaatctccgg cagcagatta tcgatggcag ccaagacaga ctgagcatca cgctgttgaa
4012261 tggacgtcac ttacttttgc ctctccgggt tgcgaactta gagaaagact agaacacgtt
4012321 ccgatttgtg tcgagctagg tattcctgcg gcaggtagcg ataccaaatg ggttttctgt
4012381 aacatgttct agttatgacg gaagagagga cgggtcttga ccgaggcaat tggagacgag
4012441 ccactcggcg accacgtcct tgaactgcag atcgccgagg tcgtcgacga aaccgacgag
4012501 gcgcgatcgc tggtcttcgc ggtgcccgac ggatcggacg acccggagat cccccctcgg
4012561 cgcctgcgtt acgcccccgg ccaattcttg acgctgcgcg tgcccagcga gcgtaccggt
4012621 tcggtggcgc gctgctactc gttgtgcagt tcgccctaca ccgacgacgc cttggcggtc
4012681 acggtcaaac gaaccgccga cgggtacgcc tccaactggt tgtgcgatca cgcgcaggtg
4012741 ggcatgcgca tccacgtgct ggccccgtcg ggcaacttcg tccccacaac cctcgacgcc
4012801 gatttcctcc tgctggcagc gggtagcggc atcaccccga tcatgtcgat ctgcaaatcg
4012861 gcgcttgccg agggcggtgg acaggtgacg ctgctctacg ccaaccgcga cgaccgctcg
4012921 gtcatcttcg gagacgcgct gcgcgagttg gcggcgaagt atcccgaccg gctcacggtg
4012981 ctgcactggc tagagtcgct gcaggggctg ccgagcgcga gcgcgctggc caagctcgtc
4013041 gcgccctaca ccgaccggcc ggtgttcatc tgtgggcccg gcccgttcat gcaggcggcc
4013101 cgggacgccc tggcggcgct gaaagtgccc gcccaacagg tgcacatcga ggtgttcaag
4013161 tcgctggaat cggatccgtt cgcggccgtc aaggtcgacg acagcggtga cgaggcgccg
4013221 gcgaccgcgg tggtggaact cgacggccaa acccacaccg tctcctggcc gcgcaccgcc
4013281 aagctgctcg acgtgctgct ggccgcgggc ctggacgcgc cgttctcctg ccgggaaggc
4013341 cactgcggtg cgtgtgcgtg caccctgcgc gccggcaaag tgaatatggg agtcaacgac
4013401 gtgctcgagc agcaggatct cgatgaggga ctgattttgg cctgtcaatc tcgcccggaa
4013461 tctgattcgg tggaagtgac ctacgacgag tagtcccgga agggagcgag atgacgcggc
4013521 tgataccggg ttgcacgctc gtcgggctga tgctgacgtt actgcccgcg cccacctcgg
4013581 cggccgggag caacaccgcc accaccctgt tcccggtcga cgaggtcacc cagctggaga
4013641 cgcacacctt cctcgattgc caccccaacg gcagctgcga cttcgtcgct ggagcaaatc
4013701 tgcgcacacc cgacggcccg acgggctttc cgcccgggct gtgggcgcgc caaaccaccg
4013761 agatccgttc gacgaaccgg ttggcctatc tggacgcgca cgccaccagc cagttcgaac
4013821 gggtaatgaa ggcgggcgga tccgacgtga tcaccaccgt ctacttcggc gagggtccgc
4013881 cggacaaata ccagaccacc ggggtcatcg actcgaccaa ttggtcgacc ggtcaaccga
4013941 tgaccgacgt caacgtcatc gtgtgtacac acatgcaggt ggtctacccg ggggtcaacc
4014001 tcacctcgcc cagcacctgc gcgcaagcca acttttccta gctaggactc gtcctggtac
4014061 tcgctgagcc ggtaaatcaa cgcggcagac ccagcagccg ttcggcggcc accgtcaaca
4014121 ggatctgctc ggtaccgccg gctatcgtca ggcaccgggt gttgaggaag tcgtacaccg
4014181 cgcggttctc gacgagcccg cccccgtcgg acacctccat caggtattcg gccagcgcct
4014241 gtcggtagcg cacgccgatc agtttgcgga cgctggattg cgcccccgga tcctggccgc
4014301 cgacggccaa ctcggcgatc cgccggtcca acagcgcacc ggcctgagcc agcaggatca
4014361 gcctgcccag ccgatcttgc tgcgcgacat cgagttccat gtcacccaag accttgagca
4014421 gctcttccat cgggttgccc agcgcggtcc cggtggccat cgcgacccgc tcgttggcta
4014481 gcgtggtgcg cgccagccgc cagccgtcgt tcacggcgcc gacgaccatc tcgtcgggga
4014541 cgaacacatt gtccaggaag acctcgttga acagcgagtc gccggtgatc tcgcgcagcg
4014601 gtcggatctc aattcccggt gtggtcatgt ccaccaggaa gtaggtaatg cccttgtgct
4014661 tcggagcatc cgggtcggtg cgcgccaggc acacccccca ccgagccttg tgagccgccg
4014721 acgtccacac cttctgtccg gtgagcagcc agccgccgtc agcccgcacc gccttggtac
4014781 gcagcgacgc caggtccgaa ccggcccccg gctcggaaaa tagctgacac caaaggaatt
4014841 caccgcgcat ggtggccggg acgaaacgtt cgatctgttc cggcgtgccg tgttcaagga
4014901 tggtcggcgc cgcccaccag ccgatcacca ggtccgggcg ctcaaccttg gccgcggcca
4014961 gttcctgatc gatcagcagt tgctcggccg gggacgcgcc gcgcccgtac ggcgccggcc
4015021 agtgcggcgc cagcaggccg gtgtccgcca gcgccacctg acgtttctcc tcgggcaacg
4015081 cggccacctc ggcgaccgcc gccgcgatct ccggtcgcag gccggccacc tcggccaggt
4015141 cgacgcccaa gcgacgacgg acaccggcct gggtcagcgc cgtaacccga cgcagccagc
4015201 gcccggatcc accgaggaac ccaccgattc cgtgggcccg gcgcagatac aaatgcgcgt
4015261 cgtgctccca ggtgcagccg ataccaccga gcacctggat acagtccttg gcgttggctt
4015321 tggcggcgtc gatgccgatg ctcgcggcca ccgccgcggc gatcgaaagt tgggtgccat
4015381 cggaatcggc tgcggcgcgg gccgcatcgg cggcggccac atcggcctgc tcggcacggc
4015441 acaacatctg agcacacagg tgcttgacag cctggaagct gccgatcggc ttgccgaatt
4015501 gctcccgcac cttggcgtag gcaaccgcgg tatcgagcgt ccatcgagcc accccggccg
4015561 cctcggccgc cagcacggta gcggccaggt cttccacccg ctcccccgac acctccagaa
4015621 cggtgaccgg tgccgatgtc agcaccatcc gggccagcgg cagcgaaaag tcggtggccc
4015681 gcagcggctc cactacgacc tcgtcgcaag cagtgtccac cagcagccaa ttcccgtcgg
4015741 ccggcaacag cacgacgccg ccgggcgcgc caccaagcac tcggccgacg gtgcccgacg
4015801 cggtcgacgt cttcgggtcg acctgcacgc caccgtcgat agccaccccg gcgaaccgtt
4015861 cacccgacgc tagcgcgctg cgcagcttgg gatcggagac aaccaaagtg gccaccgcgg
4015921 tggtcgcgac cggccccggt accaacgccc tggccgcctc gtcgaccatc gcacacaggt
4015981 cctcgatgct gccgccagct ccgccacaat cctctgggac ggcgacaccg aagaggccca
4016041 ggcccgccag cccggcgaac accggccgcc atgcgtccgc atttccttct tcgaagccgt
4016101 attccatgtc gcggaccgcc gcagtcgcgg ccgcacctga ggccgcggtg cgggcccagc
4016161 cgcgcaccaa ctcacgagcc gcggattgtt cgtcggtgac ggtcgctacc acctgcagac
4016221 ctccgcgtcg acaatttcac atagcaatgg agcgttcttg cccactagaa cgtgttctaa
4016281 tagtgctaac gatcaaccgt caagtcgaag gcaataactc cagcacatgt cgtcgtctcg
4016341 gctgtcggga ggtgggaaat ctacacacag catgcgtatc gtttgcaaac gaaccgcccg
4016401 gaagaggagc tgcccgctac atgtcgtcag cgaacacgaa caccagtagc gctcccgacg
4016461 caccacctcg cgcggtcatg aaagtggcgg tacttgccga gtccgagctc ggatcggagg
4016521 cacagcggga gcgccgcaag cgcatcttgg acgccaccat ggctatcgcg tccaaaggcg
4016581 gctatgaggc ggtgcagatg cgcgccgtcg ccgaccgcgc cgacgtcgcg gttggcacgc
4016641 tgtaccggta cttcccgtcg aaggtgcatc tgctggtgtc ggcgctgggt cgggaattca
4016701 gccgcatcga cgcgaaaacc gaccgctccg cggtcgccgg ggccaccccc ttccagcggc
4016761 tgaactttat ggtcggcaag ctcaaccgcg cgatgcaacg caatccgcta ctcaccgagg
4016821 ccatgacacg tgcctacgtg ttcgccgacg cctcggcggc cagcgaggtc gaccaggtcg
4016881 aaaagctcat cgacagtatg ttcgcgcgtg caatggccaa cggcgaacca accgaggacc
4016941 agtaccacat agcgcgggtg atctcggacg tgtggttgtc gaacctgctc gcgtggctta
4017001 cccgacgagc ctcggctacc gacgtcagca agcggctgga cctggccgtg cggctgctga
4017061 tcggcgatca agacagcgcc tagaagactt acgccggcgg acccgcggtg cggccccgga
4017121 ccagctcggt atcgagcacc tcgatgacgg gcagtccgga ccgcggcggc ttcagcaata
4017181 gctcgcccgc ccggtgcccc ttgtgcagac tcggctgcgc gaccgtggtc agcccccggc
4017241 tcagcgcctc tggcactccg tcaaaccctg tgacggtcat ctgcccgggc acgtaaatcc
4017301 cgtgcgcccg aaggtaatcc atagctgaga gcgccaagat gtccgctgtg cacatcagcg
4017361 cggtcagccg cggattggcc tgcagagcca ccttggcggc agtgccgccg gacgtcggca
4017421 aatgctcgta gctttccacc acggtcagcg agtccgggtc gacgccggcg gccgtcatcg
4017481 cctcccatac gccgacgatg cgttcgcgct gtacgtcgaa ggtcggcgac cgcagccgct
4017541 cggcgtccac caagtcttgc cgccgatccc gtcccagccg catggtcagc aggccgagct
4017601 cgcgatgccc caacccgagt acgtagccgg caagctcacg catcgccgcc cggtcgtcga
4017661 tgccgacccg ggacactccg gagaggtctt tgggctggtc gaccaccacc accggcagcc
4017721 gccgctgcag cacgacctgc aggtagggat cgtcgtcgcc taccgaatac accacgaagc
4017781 cgtccacccc agcgccgagc acggcagctg tgccgtccgc aaggctccga ctggagccga
4017841 cggaaaccag ctgcaggccc tgccccagct cttcgcacga ctgcgccact cccgcaacaa
4017901 aatcccgcgc ggccgggtcg ctgaagaaat aggtcagcgg ttcggccatc accaaaccga
4017961 ccgcaccggc tttgcgggtc cgcaacgatc gcgccaccgg atccggtccg gcatagccca
4018021 gtcgcttggc cgtggcaagc actcgttcac gtagatcggc ggagagctga tccggtcggt
4018081 taaaagcatt cgagacagtg gtgcgggaca ccttgagctc ggctgctaac gacgccagag
4018141 tcgcccgcct ccgcggtgtg ggactcacgt tcggtgaggg tacagcggac cctcgagcac
4018201 gcaatatcgt gggccggctg gcaaccgtcg gtttcgacgt tggtgacgac ccctcgttca
4018261 tgaatcgttc ttgagctccc cgttttgctg gatgcccagg caccgccggt actgctgcgc
4018321 ttaagcttgt cgcacatggt gccggcaggg aggaacagtg ggcaagcagc tagccgcgct
4018381 cgccgcgctg gtcggtgcgt gcatgctcgc agccggatgc accaacgtgg tcgacgggac
4018441 cgccgtggct gccgacaaat ccggaccact gcatcaggat ccgataccgg tttcagcgct
4018501 tgaagggctg cttctcgact tgagccagat caatgccgcg ctgggtgcga catcgatgaa
4018561 ggtgtggttc aacgccaagg caatgtggga ctggagcaag agcgtggccg acaagaattg
4018621 cctggctatc gacggtccag cacaggaaaa ggtctatgcc ggcaccgggt ggaccgctat
4018681 gcgcggccaa cggctggatg acagcatcga tgactccaag aaacgcgacc actacgccat
4018741 tcaagcggtc gtcggcttcc cgaccgcaca tgatgccgag gagttctaca gctcctcggt
4018801 gcaaagctgg agcagctgct cgaaccgccg gtttgtcgaa gtcacccccg gacaggacga
4018861 cgccgcctgg actgtggctg acgttgtcaa cgacaacggc atgctcagta gctcgcaggt
4018921 tcaggaaggc ggcgacggat ggacctgcca gcgtgccctg actgcgcgca acaacgtcac
4018981 tatcgacatt gtcacgtgcg cctatagcca accggatttg gtggcgattg gcatcgctaa
4019041 ccaaatcgcg gccaaggttg ctaagcagta ggcatggccg acggtcccct tgccatcacg
4019101 gcgaaatcgg tttacataca tggctattcg gtagatacgg cagagattcc aacagctgtg
4019161 cgtggccacc cgaatgccgc gggaaccgcg atcaaggacc gccgctgatg cggccgaaac
4019221 ttgggcgtcc caatatcgcg cggtattcca acaggtttag cgtgcctacc gccagatccg
4019281 atgctccgtt gtcggtgacc tggatgggcg ttgcgacgct gctggtcgac gacggatcgt
4019341 cggccctgat gactgatggc tacttttccc ggcccggcct ggcacgggtg gcggcgggta
4019401 aagtgtcgcc gtcagcggag cgggtcgacg gttgccttgc ccgggccaat gtctcccggc
4019461 tgacggccgt tatcccggtg cacactcaca tcgaccacgc gatggattcc gcgctggtcg
4019521 ccgaccgtac cggagcccag ctggtcgggg gggagtcggc ggccaatgtc gggcgcggat
4019581 acgggttgcc tgaggagtct cttgtcgtcg ccgtcccagg tgaaccaatc cagttgggcg
4019641 ccttcgacgt gacgttggtg gagtcgcatc actgcccacc cgaccggttt cccggtgtga
4019701 tcagcgcacc actgacaccg ccggtgaagg cgtcggccta ccgctgcggt gaggcgtggt
4019761 cgacgctggt gcaccaccgg ccatcggggc gccggctgtt aatccaggac agcgccggtt
4019821 tcgtcagcgg cgcactggcc ggttaccgcg ccgatgccgc ctacctcagt gtcggccagc
4019881 tcggcctgca accgccgtca tacctgctcg aatactggac cgagaccgtg cgcacggtgg
4019941 gcgtccgccg cgtgattctc atccactggg acgacttttt tcggccgctg tcaaagccgt
4020001 tgcgggcctt gccatatgcg gccgacgacc tagacctgtc gatccgcatc ctcgacgagc
4020061 tggccgccca ggacggcgtc gcgctgcaga tgccgacggt gtggcgccgc gaggatccct
4020121 ggatgtgaag cgctctagcc cttgacactt gctgttgcgc tgatactgct tgccgtggtc
4020181 ctggggttcg cggttgcccg cccacgcggc tggccggagg cagcggcggc ggttccggca
4020241 gcggtcatcc tgttagcgat cggggcgatc tcgccccagc aggcgatggc gcaggtgtcc
4020301 gggctggcgc gcgtggtcgc gtttctgggt gcggttctgg tgctggctaa gctgtgcgac
4020361 gacgaaggcc tgttcgaggc agccggcgcg gccatggctc gagcgagcgc ggagtcgcac
4020421 cgactgctac ggcaggtgtt cgccgtctcg gccgccatca ccgcggcgct ctgcctggac
4020481 gccaccgtgg tgctgttgac cccggtggtg ctggcgacgg tccgccggct gcggaccccg
4020541 gtgcgcccct atgcctacgc caccgcccac ctagccaacg ccgcttcgct gctgcttccg
4020601 gtgtcgaatc tgaccaacct gctcgcctac cacggtgccg gcatctcgtt caccaagttc
4020661 acgctgctga tggcattgcc ttggctgtcc gccgtggccg cggtctatgt ggtcttccgc
4020721 tggtttttcg cccgggatct acgcgtggtg ccggaccggc agcaactcaa gccggcgccg
4020781 cgcctgccaa tgttcgtgct ggtggtggtg gcgctgacac tcgggggctt cgccgtcgcc
4020841 gagtcggtgg gactggcccc aacgtgggcg gcgctggctg gcgccgcagt gttggcgctg
4020901 cgaagtctgc ggcgtggaca cacttcggtg ctgcggatcg cgcgcgccgt caacgtgtcg
4020961 ttcctggtct ttgtgttggc cctgggtgtc gtggtgcacg cggtcatgct caacggcatg
4021021 gccgccagga tgtccgccgt gctgccgacc gggtccgggt tgcccgcgct gctcggcatc
4021081 gccgcgctgg ccgccgtgct ggccaacgtg gtcaacaacc tgcccgcgac tctggtgtta
4021141 gtgccgctgg tggcggccgg cgggccggcg gccgtgctgg ccgtgctact cggggtcaac
4021201 atcggaccca acctgaccta tgccggttcg ctgtctaacc tgctgtggcg gggcgtgctg
4021261 cgccggcaca acgtcgacgc cagcgtcggc gagtacaccc gactgggact gtgcaccgtg
4021321 cctgcggccc tggcgatggc ggtgctcgcg ctgtgggcca gcgcccaggt tctggggatc
4021381 tagccgcaag ggcgcgagca gacgcagaat cgcatgattt gagctcaaat catgcgattc
4021441 tgcgtctgct cgcgaggctc gcgtggccgc cggcgctggc gggcgatctc ggcgagcacc
4021501 accccagcgg ccaccgaggc gttcagtgat tcggcctgag cggccatcgg gatggacacc
4021561 acctcgtcac agttctgcct taccaaccgg gacaacccct tgccttccga cccaacgacc
4021621 accaccaacg agtcagtgcc atctacatcg tcgagcgcgg tgccgccacc ggcgtccagt
4021681 ccgatcaccc gcactccacg atcggcccag cccttcagcg tcctggtgag attggtggcc
4021741 cgggccaccg gaatccgggc cgccgccccg gcgctggtgc gccacgccac cgcggtcacc
4021801 gacgcagaac ggcgttgcgg aatcagcacc ccatggccac cgaacgcggc caccgaccgc
4021861 acgatcgcac cgaggttgcg cgggtcggaa aggttgtcca aagcgaccag cagcgcaggc
4021921 ggttggtcga gggcggcggc cagcaggtca tcgggatggg cgtagttgta cggtggcacc
4021981 tgtagcgcga tgccttgatg gaggtggttg gcggtcatcc gatccaggtc ggcacgtagc
4022041 agctcgacga tcgcaatccc tgaatcagcc gcccgcgcaa cgcattcagt cagtcgctcg
4022101 tcggcctcgg taccaagggc gacgtatagc gcggtggccg gaacacccgc gcgcaggcat
4022161 tccagcactg ggttgcgacc caacaccgtc tcggtctcgt ccgcgcgctt gaccgggcgg
4022221 cgtggctgtg cacgtgcccg cttggcggcg ggatggtggg gacgcaggtg cgccggcggg
4022281 gtaggcccgc gcccttccag cccacggcgt cgctgaccgc ccgagccgac gcctgcgcct
4022341 ttcttggtac cggatttgcg gaccgcaccc cgccgccgag agttaccggg catctacttg
4022401 gtgtcaccac ccagcagcga ccactgtggc ccgtcggcgg tgtcggtgac ctcgatgccg
4022461 gctctcttca gccgaccccg gatctcgtcg gcgagcgccc agttgcgctg ctcgcgggcc
4022521 ttttcccgat tctgtagttc agcctggacc agcacatcga cggcggccag cgctgccgag
4022581 gtttcgtctc gggattccca gcgctggtcg agcgggtcac agcccaggat gcccatcatc
4022641 gcccgaatcg cgctagcgct tcgcaaggcc ccgtcgtggt cgccggcatc gagtgcccgg
4022701 ttgccttccg cccgcacgtg gtgaatctcg gcgagcgcga tcggaacgga caggtcgtcg
4022761 tcgagcgctt cggcgaaccg tggggtcgga tcgccggggc agacggcgcc cacccgggtg
4022821 cgaacgcggt gcaggaagtc ctctagcccg acataggctt tcaccgcatc ctgcatagcg
4022881 gtctcggaga actcgagcat cgaccggtag tgcgcgctgc ccaggtaata acgcagctca
4022941 gccggccgca cccgctgcaa catcgccggc atggacaaca cgttgcccag cgacttgctc
4023001 atcttctccc cgcccatcgt cacccagcca ttgtgcagcc agtagcgggc gaacccatca
4023061 ccggcggcgc ggctctgggc gatttcgttc tcatgatgcg ggaagactaa atccattcca
4023121 ccgcaatgga tatcgaattc cggcccgaga tagctgcgag ccattgccga gcattccaga
4023181 tgccagcccg gacgcccgcg gccccacggc gtcggccacg acggttcacc cggcttttcg
4023241 cccttccaca aagtgaagtc gcgctggtcc cgcttgccgg cagccacacc ttcgccctga
4023301 tggacgtcat cgatcttgtg accggataac tggccgtact ccgggtagct cagaacgtcg
4023361 aagtaaacgt caccgccacc ggtatacgcg tggccggcct ggatcaggcg ctcgatcatc
4023421 tcgatcatct gggtgatatg cccggtggcg cgcggctccg cggacggcgg caagacgtcc
4023481 agagcgtcgt aggccgcggt gaaggcacgc tcgtgggtag ccgcccactc ccaccacggc
4023541 cggcccgccg cggcggcctt ggccaggatc ttgtcttcga tgtcggtcac gttgcggata
4023601 aacgcgacgt cgtagccacg cgcgagcaac catcggcgca ggatgtcgaa ggcgaccccg
4023661 ctgcggacat gcccgatatg cggtaggccc tgcaccgtgg caccgcacag gtagatcgag
4023721 acgtgtccag gtcgcaacgg gacgaaatcc cgcacgacac cggcggcagt gtcgtgtagc
4023781 cgcaagcgag cccgatcggt cacgacgtgc cagcttacct gcccaattgc tgcaacctgc
4023841 ggcgcgcgcg tccggaccag gagtgcgcta ccgcaacgaa accaccaatg ccgtagcgat
4023901 tgcggccaag ccctcgccgc ggccagtgag gcccagcccg tcggtggtgg tagccgacac
4023961 cgacaccggc gcgttgagca gacgtgacag caccgcctgc gcctcgagcc ggcgccaacc
4024021 gatcttcggt cggttgccga tcacctgcac cacagcgttg ccgacccgat agccatgctg
4024081 ggtgatcagg acgacgacat ggcgcaacat gtcggcacca ctgacaccct gccaacgggg
4024141 atcgtcgacg ccgaacacct cgccaatgtc gcctagcccc gcggccgaca gcaccgcgtc
4024201 gcacagcgca tgaacggcca cgtcaccgtc ggagtggccc gcgcaaccgt cggcgctcgg
4024261 gaacaacaac cctaccagcc agcacggacg tccgggttcg atcggatgca catcggtccc
4024321 caaaccaacg cggggcagct gattcacccg cgcactatag cttgggccag caacagatcc
4024381 agtttggtgg tgatcttgaa cgccagcgga tcgccgtcga ccacctgcac ctggccgccg
4024441 atatgctcga ccagcgacgc gtcatcggtg tactcggcgg ctggaaggtc tagggagccg
4024501 cgctgatatg accgcagcag caggtcggta gtgaaccctt gtggggtctg cacggcccgc
4024561 agcccggctc gttccggcgt gcccaggacc accccgttgg catccacggc cttgatggtg
4024621 tcagaaagcg gcagtacggg aacgacggcg gcataaccgt cccgcaacgc ctcgaccacc
4024681 cgggcgacca gggccggtgg tgtcagtgcc cgcgcggcat catgcacaag cacaaactcc
4024741 ggctccgcgg tcccggacag cactgtcagc gccaggttca cggtgtcagt gcgattcgac
4024801 ccacccgcca caatcatcgc cctgtggccg aggatctgcc tcgcctcgtc cgtacggtcg
4024861 gcgggcacgg ccacaacaac ggtgtcaact acccccgaat ccagcaggcc atcgacggcc
4024921 cgctcaatga gagtctgccc gtcgagctgg taaaacgcct tgggcacacc gacggccaac
4024981 cgctcccccg accccgcagc cgggacgatc gcaactactt cgcccgcttc cctgaccact
4025041 agagcctcag ggcggtcaag acgcggcggc taaaacctcg tcaaggatgg tctcggcttt
4025101 ggcgtcatcg gtgctctcag ccaacgccaa ctcgccgacc agaatctgcc gggccttggc
4025161 cagcatgcgc ttctcaccgg ccgacaagcc acgctcctgg tcgcgacgcc acaaatcgcg
4025221 cactacctcg gccaccttgt tcacatcgcc ggatgcgagt ttctcgaggt tcgccttgta
4025281 acgacgtgac cagttcgtcg gctcctcggt gtgcggggca cgcaacacct ggaaaacctt
4025341 gtccaggcct tcctgcccga cgacatcgcg aacaccgacg tattcggcgt tttcagcggg
4025401 aactcgtact gtcaggtcgc cctgcgcaac tttcaagacg agatactctt tttgttcccc
4025461 tttgatggtc cgggtttcga tcgcctcgac taacgcagca ccgtggtgtg gatagacaac
4025521 ggtgtctccg accttgaaaa tcatctgatt tgagcccctt tcgttactcc atgctaacac
4025581 ggggccctaa cgggcgccga acaacggtgc aggtcagggg catagcgcgg gaagattggg
4025641 ggttgacaga cgggcctaga agtgcatcgc cgaatctggg acgcccctga gaacggggtg
4025701 cccgggctac cgcgccggtc cggtcgacgc cgcggtcccc accgctaccg tcggcggcac
4025761 ctaactacta ctgtgcatag tcgagccgca ggcaccatgc cgcgccaagg ccgagcagga
4025821 ggcatccgag tgaaccgctg caacatccgc ctgcgtcttg ccgggatgac cacctgggtg
4025881 gcgagcatcg ccctgctggc cgccgcactg agcggttgcg gggccggtca gatctcccag
4025941 acagcgaacc agaagccggc cgtcaacggc aatcggctca ccatcaacaa cgtgttgctg
4026001 cgcgacatcc gcatccaggc cgtccaaacc agcgatttca tccagccagg caaagcggtg
4026061 gatctggtgc tggtagccgt caaccaatca cccgacgttt cggaccggct ggtgggcatc
4026121 accagtgata tcggctcggt gacggtggcc ggcgacgctc gactgcccgc atccgggatg
4026181 ctttttgtcg ggacgccgga cggccagatc gtggcgccgg ggcccttgcc atccaatcaa
4026241 gcggccaagg cgaccgttaa cttgaccaag ccgatcgcaa acggcctcac ctacaacttc
4026301 accttcaagt tcgagaaggc cggtcagggc agcgtaatgg tgccgatctc ggccggattg
4026361 gctacgccgc acgaataggc gccgcatcgt cgccagacga gcgactcgct cgggttgtca
4026421 cacccccccg atacggtcac ggcgtggcca acgctcgttc gcagtaccgc tgttcggaat
4026481 gccgccatgt cagcgcgaag tgggtgggac gctgcctgga gtgcggccgc tggggcaccg
4026541 tagacgaggt ggcggtgctc agtgccgtcg gtggcaccag gcgccgttcg gtggcgccgg
4026601 cgtcgggcgc cgttccgatc agtgccgtcg acgcgcatcg gacccgaccc tgcccaaccg
4026661 gcatcgacga actggaccgg gtgctaggtg gcggtatcgt tcccggttcg gtgacactgc
4026721 tggccggcga tcccggagtg ggtaagtcga cgctgttgct cgaggtcgcg caccgctggg
4026781 cccagtccgg acggcgcgcg ctctatgtct ctggtgagga atccgccggt cagatccggc
4026841 tgcgtgccga ccggatcggc tgcggcacgg aggtcgagga gatctacctc gccgcacagt
4026901 ccgacgtgca caccgtgctc gaccagatcg agacggtgca gccggcactg gtcatcgtcg
4026961 actcggtgca gaccatgtcc accagcgagg ccgacggcgt caccggcggg gtcacgcagg
4027021 tccgtgcggt tacggctgcc ctgaccgctg ccgccaaggc caacgaggtc gcattgattc
4027081 tcgtcggcca cgtcacgaag gacggggcca tagccggacc gcgttcgcta gagcacctcg
4027141 tcgacgttgt gctgcatttt gaaggggacc gcaacggtgc gctgcggatg gtccgcgggg
4027201 tcaagaaccg attcggcgcc gccgatgaag tcggatgttt cctcctgcac gacaacggaa
4027261 ttgacggtat cgtcgacccg tcgaacctgt tcctggacca gcggccgaca cccgtcgccg
4027321 gtaccgcgat caccgtgacg ctggacggaa aacggccgct cgtcggggaa gtccaggcat
4027381 tgctggccac accgtgcggc ggctcgccga ggcgggccgt cagcgggatc caccaggccc
4027441 gcgctgcgat gatcgctgct gtgctggaaa agcacgcacg gctggcgatc gccgttaacg
4027501 acatctacct gtccaccgtg ggcggcatgc ggttgaccga gccgtcggcg gatctggcgg
4027561 tcgccatcgc gctcgcctcg gcctatgcaa atctgccgct gcccaccact gccgtcatga
4027621 tcggcgaggt aggtctggcc ggcgacatcc ggcgggtcaa cgggatggcg cggcgcctta
4027681 gcgaagccgc ccgccaaggg ttcaccatcg ccttggtccc gcccagtgac gatccggtgc
4027741 cgcccggtat gcacgcgctg cgcgcatcca ccatcgtcgc ggcgctgcag tacatggtcg
4027801 acattgccga ccaccgcggc accaccctcg caaccccgcc ctcacattcc gggactggac
4027861 acgtcccact agggcgcggt acatagcaga atgcacgctg tgactcgtcc gaccctgcgt
4027921 gaggctgtcg cccgcctagc cccgggcact gggctgcggg acggcctgga gcgtatcctg
4027981 cgcggccgca ctggtgccct gatcgtgctg ggccatgacg agaatgtcga ggccatctgc
4028041 gatggtggct tctccctcga tgtccgctat gcagcaaccc ggctacgcga gctgtgcaag
4028101 atggacggcg ccgtggtgct gtccaccgac ggcagccgca tcgtgcgggc caacgtgcaa
4028161 ctggtaccgg atccgtcgat ccccaccgac gaatcgggga cccggcaccg ctcggccgag
4028221 cgggccgcga tccagaccgg ttacccggtg atctcagtga gccactcgat gaacatcgtg
4028281 accgtctacg tccgcgggga acgtcacgta ttgaccgact cggcaaccat cctgtcgcgg
4028341 gccaaccagg ccatcgcaac cctggagcgg tacaaaacca ggctcgacga ggtcagccgg
4028401 caactgtcca gggcagaaat cgaggacttc gtcacgctgc gcgatgtgat gacggtggtg
4028461 caacgcctcg agctggtccg gcgaatcggg ctggtgatcg actacgacgt ggtcgaactc
4028521 ggcactgatg gtcgtcagct gcggctgcag ctcgacgagt tgctcggcgg caacgacacc
4028581 gcccgggaat tgatcgtgcg cgattaccac gccaacccgg aaccaccgtc cacggggcaa
4028641 atcaatgcca ccctggacga actggacgcc ctgtcggacg gcgacctcct cgatttcacc
4028701 gcgctggcaa aggttttcgg atatccgacg accacggaag cgcaggattc gacgctgagc
4028761 ccgcgtggct accgcgcgat ggccggtatc ccccggctcc agttcgccca tgccgacctg
4028821 ctggtccggg cgttcggaac gttgcagggt ctgctggcgg ccagcgccgg cgatctgcaa
4028881 tcagtggacg gcatcggcgc catgtgggcc cgtcatgtgc gcgaggggtt gtcacagctg
4028941 gcggaatcga ccatcagcga tcaataatta tccgccttgc gcgggagact ccggcggagg
4029001 cgcctgcgct ggacccggag cgggtaccgg cccgggcggc ggcggcggct gattcaggat
4029061 gaacggaacc ggcagcgagc gcagattgcc cagttgtacc acgagattgt aggtgcccgg
4029121 cccgatcgcc ggccgcggca atgggcagcg cggcgccgat cccatcccgg tccaggtcac
4029181 cgcggtcgtt acctgctcac cgggggaaaa cgtcttgacc agcgtctcat tcgagggcgc
4029241 gcagtccagg ttggaccaca accgcttgtt gtccagcgag taaacgtagg cggccaacac
4029301 cgcggcccca acgtcgcgtt tacaggacac caggccgatg ttggtgacca ccatggtgaa
4029361 cttcggctgg tcgccgacgt agtactgcgg cgcgttggtc aaacctttga cggccagcgt
4029421 cgaatcgggg caatcgtccc cttccttgag caccggcggc ggctgcaccg cggcggtggg
4029481 cgtgggtgtc tcggggtttt ggccctgcgg cggggccgcg gcggcgttac cttcggtttg
4029541 cccggccggc tggggtgctt ggggtgccgg cgagcccgga tggctctggg cggaggccgg
4029601 cttgtcggcg ctgaccggtt tggcaccggc gctgctgtcg acgaaggcga tgacgatggc
4029661 caccgcgatc ccgactacga cgaccgcgat gcccagggcc agccccctgc gccgccagta
4029721 gatctcggta ggtagcgggc cacgcggttc cagatccagc acgattacac cgtagggcca
4029781 ggtcacgcaa acgcgcttga cccgcctcgg cgtgtcgccg gcttcgctgg ccgacgccgt
4029841 gttaacggtg gcctgttatc gggcggtaac tcagacctcc tcgccgatgt tgccgatgtg
4029901 gtcgcgcagt acagcccgcc catcgtcgag ttgataggtg acgcccacga tcgccaggct
4029961 gccccctgcg attcgttctg agatggccga tgaacgcgcc atgaggatcg ccaccgtctc
4030021 gtgtacatgt cgttgctcga actcgtcgac acgactcaga ccgtcacggc ggccgagcag
4030081 gaccgacggc gcaacccttt ccacgacgtc tcgcacgtag ccgcctggca gggtgccgtc
4030141 gttgatcgcg gccaaagcgg cgttcacggc gccgcagctg tcgtggccga ggacgacgat
4030201 gagcggcaca ttgagcacgg tcaccgcgta ctctatggag cccagcacgg ccgagtcgat
4030261 gacatgcccg gcggtgcgga ccacgaacat gtcgcccagg ccttggtcga agatgatctc
4030321 agcggccact cggctgtccg cgcagccgaa gatcaccgcc gtgggcttct gcccggcggc
4030381 caagccggct cggtggtcga cgctctgact gggatgctgg ggccggccgg cgacgaatcg
4030441 ctcgttaccc tctttgagtg ctttccacgc ggctaccgga ttggtgttgg gcatgcctca
4030501 catactgccg gaaccgtcgg tgaccggccc gcgacacata tcagatacca atcttctcgc
4030561 ttggtatcag cgatcgcacc gggatctgcc ctggcgagag cccggtgtca gcccgtggca
4030621 gatcctggtc agcgagttca tgctgcagca gacgccggcc gcccgggtgc tggcgatctg
4030681 gccggactgg gtgcggcggt ggcccacgcc gtcggccacc gccacggcca gcaccgccga
4030741 tgtgttacgc gcctggggca agctgggcta tcccaggcga gccaagcgct tacacgagtg
4030801 cgccaccgtc atcgcccgcg accacaatga cgtggtgccc gacgatatcg agatcctggt
4030861 caccctgccg ggcgtcggga gctacaccgc gcgcgcggtg gcgtgtttcg cttaccgcca
4030921 gcgggtgccg gtggtggaca ccaatgtgcg gcgcgtggtg gcccgcgccg ttcacggccg
4030981 cgccgacgcc ggtgcgccat cggtgccgcg cgaccacgcc gacgtcttgg cgctgttgcc
4031041 gcaccgcgag acggcgcctg aattttcggt cgcgctgatg gagttgggtg cgacggtgtg
4031101 caccgcccgc acaccccggt gcgggttatg cccgctggac tggtgcgcat ggcggcatgc
4031161 cggttatccg ccgtcggacg gtccgccgcg ccgggggcag gcctacaccg gaaccgaccg
4031221 ccaagtccgc ggacggttac tggatgtgtt gcgcgccgcg gagtttcccg tcacccgggc
4031281 cgagttggac gtggcgtggc tgaccgatac cgcacagcgt gaccgggcgc tggagtcgct
4031341 gctggccgat gcgctggtga cccggacggt cgatggccgg ttcgcgttgc ccggcgaagg
4031401 gttttagccg ggtaggccgt ccgcaccggc ggcgccgaaa ccgccgggat caccggggtt
4031461 gcccgcgacg actgtcccag ctcccgcggc gccacccgcg ccgccagcgc cgccggcacc
4031521 tccctggccc ccggtaccgc ccgcaccgtg gacacctggc tggctgaaca ttccggcacc
4031581 tccgccggca cctccggcac cgcccttgcc gccgttgccg ccggcgccgc cggcaccacc
4031641 gttgccgccg tcaccgccga ccaggccaga gccgcccttg cctccggcgc cgcccgaggc
4031701 acccgtgccg ccgatgccgc cggcaccgcc ggcgcccccg ttaccgccgt cgccgaacag
4031761 cagcccgccc tgaccgcccg cacccccgac accgccgaca cccccggtgc cggcggtgtt
4031821 ggcgccagcc ccgccggggc cgccgtcgcc tccgctacca aaaaaggtca gcgtgccggt
4031881 ggcgccgccg ccaatgccac cattgccgcc cgcagccccg gtgccgcccc ggcccccggc
4031941 gccaccgttg ccgccgatcc cgttgccacc gtttagcgct aggccgttgc ccccgttgcc
4032001 cccgtcgccg ccccgggcgc cggcgccacc gtcaccgcca ttgcccccgt ttcccccgta
4032061 ggcccagcca gtaccggtat tgacaccgat gccgccgggt gcgccgttgc cgccgggcgc
4032121 gccgggaccg ccgtcgccgc cattgcctcc gttgcccccc gtcacagggc cttcactcgt
4032181 atcgctgccg ctgccgccta aaccgccagc gccgccagcc cgccctggta cggcacccgg
4032241 gttgccgggc agccctgcgc caccgctacc ggcgccgttg ttggcgccgg ggcttccgtt
4032301 tgccgcctgg ctggtctggt tcggcggcgg gttcatcccg ttggttccgg gggcacccac
4032361 cccgccgacg ccgccgtcgc cgccggcgcc gatcagcccc gcgttgccgc cggcaccccc
4032421 attgccgggc aacccgccga tgaccgcggc cccgcccgcc ccgcccacac cgccattgcc
4032481 gaacgcgccg gcggcgccgc cggctcctcc gttgccactg acggtcgttc ccaccccgcc
4032541 gaacccgccg gcaccgccgt tgccgaccag ccagcccgcc ccaccggctc cgcccacacc
4032601 gccggcgccg gcggcgttgc tcccgccggc cccgccattg ccgccgtgcc cgaacagccc
4032661 ggcggcgccg ccgctaccac cgggcccgcc cacaccggcc acacccgacc cgccgttgcc
4032721 gccattaccc cacagcagcc cgccgggccc gcccggctgc ccggttcccg gcgccccgtc
4032781 ggcaccgttg ccgatcaacg ggcgccccag tagcgtctgc gcgggcccgt tgatcaagcc
4032841 gagcacctgc tgctccacgg cttgcagcgg cgacgcgttg gcggcctcgg cgctggcata
4032901 ggagttcact cccgcgttta acgcctgcac gaactgggca tgaaaccccg ccgcctgggc
4032961 gctgagcctc tggtactcct gggcgtgcgc gccgaacagc gccgccatcg ccgccgacac
4033021 ctcgtccgcg gcggccgcta gcacacccgt ggtcggggcg gccgcggcgg cgttggcggc
4033081 attgagcgcc gaaccgatac cggccacctc tgaagccacc gacatcagcg cttccggcgc
4033141 cacgatcaca aacgacatct gacacccctt tccgcggcgc ggcctgacgg cccgatcgta
4033201 gcgcgatcac gggccgacaa aacccgttat ggccaggctt ttcgccacat tgcccgcgcc
4033261 gcgtgggctc acggggtaag ccccgccagg aacgactcca ccgcccgccg gtaaacctgt
4033321 ggagcctcgt catgaaccag atgaccggcg tcgggaacac gcaaatacgc tgtcggataa
4033381 tctctttcag ccatcgcgcg catctggccc gggggagtta ccccatcgcc ggcctcgatg
4033441 agcagcgccg gcgaccgtac ggcccgccac tgcgcccagt agtcacgggt gccccattcg
4033501 gcggcgatct cgatccatcg tgcggtgcgc ccgtgtagcc gccacccggt ggccgtgcgg
4033561 tcgaatgcgt ccaggaagta ccggccggcg acgggcccga actcggcgaa tacctgttcg
4033621 gcagagtcga attcgaccgg aagggcgcgc agccacggct cccatgggcc ggtggtccta
4033681 ccacggaagt ccggcgccat gtcctcgacc accagcgccg aaaccagttc cgggcgctcg
4033741 gcagccagac accacgaatg caaggctccc atcgaatgtc cgaccatcct ggtcggcgcg
4033801 cccagcgccg aaaccgcgtc gcccagatcg gccacgaagc gttcggtgct gatcgggtgt
4033861 ggatcggcga cgtcacgccc gcggtgccag ggcgcgtcgt aggtgtacac ggcgcctaac
4033921 agcgtcagcc acggaagctg acgggcccag gtggaacccc tacccatcaa gccgtgcacc
4033981 aggaccaacg gctcgccccg tccgccgcga tgggttaaca gattcgctgg catgcggggc
4034041 acggtagcct agcggcatgc cagtggtgaa gatcaacgca atcgaggtgc ccgccggcgc
4034101 tggccccgag ctggagaagc ggttcgctca ccgcgcgcac gcggtcgaga actccccggg
4034161 tttcctcggc tttcagctgt tacgtccggt caagggtgaa gaacgctact tcgtggtgac
4034221 acactgggag tccgatgaag cattccaggc gtgggcaaac gggcccgcca tcgcagccca
4034281 tgccggacac cgggccaacc ccgtggcgac cggtgcttcg ctgctggaat tcgaggtcgt
4034341 gcttgacgtc ggtgggaccg gcaagactgc ataaccggcg cgcggggcgc cggatgctgg
4034401 cgttaagcgc cgcggcggca ttgattgtgg cgctggcgtc gggttgctcc tcagctccga
4034461 cgccgtccgc gaacgcggca aatcacgggc accggatcga caccagaact ccgcctggtc
4034521 tgcgggcgca acagaccatg gacatgctca actcggactg gccgatcggc gagatcggcg
4034581 ttggcactct cgccgcgccc gggcaggtcg acacggtcaa gaccaccatg gaagcgctct
4034641 ggtgggatcg cccgttcgcg ctggccggcg tcgatatcgg cgccagtgtg gccgcgttgc
4034701 acctcatctc ctcttacggc gcgcaacaag acatccgcat tcataccgac gacgacggct
4034761 gggttgaccg attcgacgtc gaaacgcagg cgccgtcgat cgcttcgtgg cgcgacgtcg
4034821 acgcggcgct gagcaagacc ggcgcccgct actcatttca ggtggcaaag gtcgacaacg
4034881 gtcgctgcga cccggtggcg ggcaccaaca ccggcgaatc cctgccgctg gcatcgatct
4034941 tcaagttgta cgtgttacat gcgctggccg gtgcggtcca gcacaacacg gtgtcctggg
4035001 atgatctgct gacggtcacc gccaaaagca aagccgtggg ctcttccggc ctggaactgc
4035061 ctgtgggggc acgtgtttcg gttcgcacag ccgccgagaa gatgatcgcc accagtgaca
4035121 acatggccac cgacttgctg atcgaaaggc tgggcacccg cgccatcgag gaagcgctgg
4035181 ccagcgccgg ccatcacgat ccggccagca tgaccccctt ccccacgatg tacgagctgt
4035241 tctccgtcgg ctggggcaag ccagatctgc gtgaccagtg gaagcatgcg acccaacagg
4035301 tccgtgccca gatactgcgg caaaccaatt ccacgcccta ccaacccgac ccaacgcgcg
4035361 ctcacactcc ggcgtcaaac tacggtgcgg aatggtacgg cagcgccgaa gatatctgcc
4035421 gtgtgcacgc ggcactgcga gccgacgcgg tcggcccggc ctcgcccgtc cgacagatca
4035481 tgtccgccgt cccgggtatc cagctggacc gcagcgtgtg gccctatatc ggcgcgaaag
4035541 caggtggcct gccaggcgat ctgacgttca gctggtacgc cgtcgacaag accggccaac
4035601 catgggtggt gagctttcag ctgaactggc cccgcgatca cggaccgacg gtgaccggct
4035661 ggatgctgca ggtcgccagg caagtctttg cgttgatagc gccacaatag atcgctacag
4035721 cccaggcatc cggaggtatc cgcggctcgc ttccgtaacg accggccggt cgtgctcgac
4035781 gtgaacaacg agacacttcc cgcgccggtg cgttcgacgg ccgattcgct ccggctcacc
4035841 gataggaggc gccaccgtgg gatggatcgg cgatccgatt tggctcgagg aggtgctacg
4035901 gccggcactc ggcgagcgcc tgcgggtgct cgacggctgg cgggaacgcg gacacggcga
4035961 ctttcgcgat atccgcggtg tgatgtggca ccacaccggc aactcacgtg agaccgccaa
4036021 aagcattgcc cgcggccggc ccgacttacc cggcccgctg gccaatctgc acatcgcgca
4036081 cagcggggtc gtaacgatcg tcgcggtagg cgtgtgctgg cacgccggcc gcggcagcta
4036141 cccgtggctg ccaaccgaca acgccaactg gcacatgatt ggcgtcgagt gcgcgtggcc
4036201 gaccatccgg cgtgacggct cctacgacgc cggtgagcgc tggcctgacg cgcagatcgt
4036261 gagcatgcga gacgtcgccg cggcgctcac gctcaagctc ggctacgggc ccgaacgcaa
4036321 tattgggcac aaagagtatg ccggggcggc tcaaggcaaa tgggacccgg gaaacctgtc
4036381 gatggactgg tttcgcgccg aggtggcaaa ggacacgcgg ggcgagttcg accaccccct
4036441 caccccgccg ccggcggtga ttgcccgccc accgattctg cccaagccgc gcaacccgcg
4036501 tgacgatcgc atcctgctcg aggaggtgtg ggaccagcta cgcggcatcg agggccgcgg
4036561 ctggccggta ctcggcgaca agacgatcgt cgactaccta gccgagctcg gcaataaggt
4036621 cgacgccctg gccgcaaaac tcgacgcgcg cgagggcctc gaccggccca gtgacactcg
4036681 gtagctgctc cagcaggcgg cggggtgctg acggacccgc tgcaacgatg tcaaccgggc
4036741 tggcccggct ggccgggctg gccgggtgca ccttcagggc cgaactggcc gaggttgccg
4036801 tcgccgccac ggcccgcagg cccaacgccc ggggagccgg ccacaccggg ctcaccaccg
4036861 cccccgccat tacccccgct accggcggca ccgcccagcc cggagctacc ggagacgccg
4036921 aacaggccgc ccgcgccgcc cgcgccgccc gcgccgccgt ctccgccggc gccgccgtca
4036981 ccgccgatcc cgccgttacc cccgtcacca gcgtcacccc caacgcctgg ttgcccggcg
4037041 ccgcccattc cgccctgacc gccggtgccg ccccgggcgc cgatgccgcc ttcgccccct
4037101 gtgcccccga tgccacctgc gccgccgtcg ccgaccagga gcccaccccg accgccagag
4037161 ccgccggccc cgccggtccc cccggtgccg ccggtcccgc cggtcccgcc aacggacagg
4037221 ccagtaccgc cagtgccacc ggtgccaccg gtttgcccga actcggtgcc tggctggccg
4037281 ggtccgcccg gttcaccgtt gttacccatg ctgccctggc ccgccgggac ggtcaggggg
4037341 ttgaccccgg cggcacccgc cgcgccggcc gcgccgagcc ccccggcccc accgttgccg
4037401 aatagccacg cgttgccgcc ggcaccaccg gcgccgccgt tgccgccggg gatagtcgcc
4037461 gccccgccgt tgccgcccgc gccgccgttg ccgtacagca gcccgccttg tccgccggac
4037521 ccgccggccg caccggctcc gccggcacca ccggatccgc cgttgccgat caacccggcc
4037581 gccccgccgc tgccgccggc aatccccgcg ttcaccccgg ccgcgccatt accgccattg
4037641 ccatacagca gcccgcccgc cccgccgttt tgcccgggcg ccgtcccgtc ggcaccatca
4037701 ccgatcaacg gacgtcccaa cagtgcctgg gtgggcgcat tgatcgcgtt cagcaaactc
4037761 tgctgaacgt tggcggcctc ggcgttggca tacgcccccg cacccgcact caaggtctgc
4037821 acgaactggg catgaaacgt cgccgcctgc gcgctgatcg tctgatacgc ctgggcgtgc
4037881 gcgccgaaga gcgccgcaat cgccgccgat acgtcatctg cgcccgcggc cagcacgccg
4037941 gtggtcggga tgctggcagc cgcgttagcc gcgctgatcg tcgaaccgag attggccaaa
4038001 tccgtggccg ccgccgacag gaactccgga acggcaatca caaacgacat tggccacctc
4038061 cgaacagctt ccggacaaac cgacgtcagc agagtctatt gtcacagcgg atcggcggtc
4038121 gcggttttcg cctaatacgg ccgatggacc tagaccgcta ccgcgcggcc ggctccgggc
4038181 cgcccgcgct gtgcgctcca gccttggcca gatccggctc ggccggcggc ttgcgggtac
4038241 cggtgaaggt gaacaccgcg tcctcgccgg gaccttcacc gtcccagttg tccacgtcga
4038301 cggtgaccac ctgacccggc ccgacctcct cgaagaggat cttctccgag agctgatctt
4038361 cgatctcacg ctggatggtg cgccgcaacg ggcgggcccc caacaccggg tcgaagccac
4038421 gcttggccag cagcgccttg gccgcatcgg tcagcaccag cgccatgtcc ttgctcttga
4038481 gctggccggc gacccggctg atcatcaggt cgaccatccg gatgatctcc tcgcgggtca
4038541 gctggtggaa gacgatgatg tcgtcgatgc ggttgaggaa ctccgggcgg aagtgtttct
4038601 tcagctcgtc gttgaccttc tgtttcatcc gctcgtagtc gttctcaccg ccgcccttgg
4038661 aaaagcccag accgaccggc ttagagatgt cggaggtgcc cagattggac gtaaagatca
4038721 gcacggtgtt cttgaagtcc accgtgcggc cctgcccgtc ggtgagccgg ccatcctcga
4038781 gcacctgcag caggctgttg tagatctcct gatgcgcctt ctcgatctcg tcgaacagca
4038841 ccaccgagaa cggcttgcgc cgcaccttct cggtgagttg gccgccctcc tcgtagccga
4038901 cgtatccggg cggcgcgccg aatagccgcg acgcggtgaa ccggtcgtgg aattcaccca
4038961 tgtcaatctg aataagcgcg tcgtcgtcac cgaacaagaa gttggccagc gccttggaca
4039021 gttcggtctt accgacaccg gacgggccgg cgaagatgaa cgagcccgac gggcgcttgg
4039081 ggtctttcag cccggcccgg gtacgccgga tggccttgga aacggccttg acggcgtcct
4039141 cttgcccgat gatccgcttg tgcagctctt cttccatccg caacagccgg gtggtctcgg
4039201 cctcggtgag cttgaacacc gggataccgg tccagttgcc cagcacctcg gcgatctgct
4039261 cgtcgtcgac ctccgcgacc acgtcaagat cgcctgaacg ccactgcttt tcgcgctcag
4039321 cacgctgtgc gaccagtgtc ttctcccggt cgcgcaggct ggcggccttc tcgaagtcct
4039381 gggcgtcgat agccgattcc ttctcccgac gagcctcggc gatcttctca tcgaactcgc
4039441 gtaggtctgg cggtgcggtc atgcgacgaa tccgcatccg agcacccgcc tcgtcgatca
4039501 ggtcgatcgc cttgtcgggc aggaaccggt cgttgatgta gcggtcggcc agggtcgcgg
4039561 cggccaccat cgccgcatcg gtgatcgaca cccggtggtg cgcctcgtac cggtcccgca
4039621 ggcccttgag gatctcgatg gtgtgctcca ccgtcggctc acccacctgc accggctgga
4039681 agcggcgctc cagcgcggcg tccttctcga tgtacttgcg gtattcgtcg agcgtggtgg
4039741 cgccgatcgt ttgcagttca ccgcgagcga gcttcggttt caggatcgag gcggcgtcga
4039801 tcgcgccctc ggcggctcca gcaccgacca aggtgtgcag ctcgtcgata aacaggatga
4039861 tgtcaccgcg ggtgttgatc tccttgagca ccttcttgag gcgttcctcg aagtcaccgc
4039921 ggtagcggct acccgccacc agcgatccca gatccagcgt gtagagctgc ttgtccttga
4039981 gcgtctcggg cacctcgccg tgcacgatgg cctgcgccag tccttcgacg accgcggtct
4040041 tgccgacgcc gggctcgccg atcagcaccg ggttgttctt ggtgcgccga gagagcacct
4040101 gcatgacccg ctcgatttcc ttctcgcggc cgatgaccgg gtccagtttg ccttccatcg
4040161 ccgccgccgt gaggttgcgg ccgaactggt cgagcaccaa ggacgtagac ggagagccgg
4040221 actctccccc gcggccgccg gtgccggctt cggcggcctc cttgccttgg taaccggaga
4040281 gcagctggat cacctgctgg cgcacccggg tcagctcggc gcccagcttg accagcacct
4040341 gggcggccac gccttcaccc tctcggatga ggcccagcaa aatgtgttcg gtcccgatgt
4040401 agttgtggcc aagctgcagc gcttcacgca agctcagctc gaggaccttt ttggcgcggg
4040461 gggtaaacgg aatgtgccca gacggcgcct gctggccctg gccgatgatc tcctcgacct
4040521 gactgcgcac accttccagc gagatcccca acgactccag tgacttggcg gcaacgcctt
4040581 ccccttcatg gatcaggcct aaaagaatgt gctcggtgcc gatgtagttg tggttgagca
4040641 tcctggcctc ttcctgagcc aggacgacga ccctgcgggc acggtcggta aatcgttcga
4040701 acatcggtgg ctacctgctc tccctcacca tcggatacag cggtcgacac cgcgtacctg
4040761 ccgtccactg taatggtcgg cctgccaggg ttcctaacct tgcggtgcct ggtcggttcc
4040821 ggggcgcagc gccccaagtc gccgttgaac agaaccgcat aggagataaa cgagaaaacc
4040881 acccaagcgt ttccggcgcc gagcggccat cggttcgccg ccagcgaacg cggcaaagta
4040941 ccggcgccca ggctttcgcc tgggcgccgg tagccaaatg tcaggtcgcc gcgtggtatg
4041001 cgtcgatgac gtcggccggg atccggcctc gcgtcgacac attgtgcccg ttacgacgag
4041061 cccattcgcg gatcgccgcg ctctgctcgc ggtcgatcgc gccacgtcca cggccggatc
4041121 cggaacggcc gcgccggcgc ccaccgacgc gacggcccgc cgccacccat tgcttcaggt
4041181 cgccacgcag tttcgtggca ttcttagtgg aaaggtcgat ctcataggtc accccgtcaa
4041241 gcccgaattc gaccgtttcg tcggcggcgc ccgaaccgtc gaaatcgtcg accaaggtga
4041301 cggttacttt cttcgccatt ggcttaccct cgcgtttctt cctgtgcagt acggatagac
4041361 tccccggtca ccaatctgcc ataagaacgc agaatactca atccagacac aacacccaca
4041421 gttcagttgg agtgtggtcg aacaatcggg aacaaaactg tctccctaat tgacaaccca
4041481 gtcaaagaca tcaacaaccg atcgataccc attccggttc cggtgcacgg tggcatgccg
4041541 tactccagag cggccagaaa atcctcgtca agcaccatcg cttcgtcatc gccagcggcc
4041601 gcggcacggg cctggtcggc gaatctctcc cgctggacta ccgggtcgct taattccgag
4041661 tagccggtgg caagttcgat tccgcgcaga tagaggtccc acttctcggt tacgccgggg
4041721 atactgcggt gctgacgggt caaaggcgtt gtctgaaccg gaaaatcctt gacaaatgtg
4041781 ggtgcgctca agctcttgcc cactgtgcgc tcccagagtt cctcgatgag tttgccgtgg
4041841 ccgaagccac ggttgtcatg aatcgctggg tctttctcca ggccaaggct atcggcgatc
4041901 ccacgtaagc gatcgaccgt cgtctgcggt gtgatctctt caccgagcgc cacagacagc
4041961 gacgggtaca tttgtatagt cgcccattct ccgtcgatgt catagacact gccgtcgggc
4042021 aacggcagtt gtctggttcc gatcgcctca tcggccacct cttgaataag ctcccgggtg
4042081 acgactgccg aatcgtcata ggttccgtag gtctggtagg tctccagcat ggagaattcc
4042141 ggagaatgcg tggaatcggc tccttcgttt cggaacactc gattaagttc gaagaccttg
4042201 tcgaaaccac ccacgatgca gcgcttgagg aacagttccg gcgcgatccg caggtacaga
4042261 tcgatgtcta gggcattgga atgagtggcg aacggacggg ccgccgcacc accggctaac
4042321 gtctgcaaga cgggcgtctc gacttccagg aacccacgac gttgaagcgc cgtccggatc
4042381 gcgcggacga cggcgatccg tagtcgagcc accgcgcgcg cttccggtcg aactatgagg
4042441 tcaacatagc gctgacgaac ccgcgactct tcactcatct ctttgtgcgc gacgggaagc
4042501 ggccgcagcg acttggcggc gatccgccag caatccgcca ggacggacag ctcgccgcgg
4042561 cgcgaactga tcaccgcgcc atgcacgtag acgatgtcgc ccaggtcgac atcggctttc
4042621 catgcgtcga gagcagcctg gccgaccttg tcgaggctga tcatcacttg cagctgggta
4042681 ccatcgccgt cctgaagtgt cgcaaagcat agctttcccg agttgcgcgc aaagatcact
4042741 cggcccgcga cgccgacgat gtcttcggtc gcggtatcga tcggcaagtc agggtgggcg
4042801 gcgcgaacct cggccaacgt gtgagtgcgc ggcaccgcga cgggataggg atcgcgcccc
4042861 tgggccagca agcgagcgcg cttgtcccgg cgaatccgga actgctcagg aaggtcttct
4042921 gctgtgtcag cggcactcac gacgtgccag cttaaatgac ctcacgccga cgctcgtggg
4042981 tggcgtcgag cctgtcggcg gcgggcgacc cggtacccag actcgatgcc ggcatcgacg
4043041 tcagcgcgcc gtcttgagcc ggccgcgctg gacttcgagg ttacgctcga acaccagccg
4043101 cagaccctgc aaggtcaggt gctggtcgta atggtcgacg gtgtgcaatt ccggcagcag
4043161 caggggcgcg gtatgcccgg tagccacgat cgcgacatcg tggtcgacgg agaaaccgga
4043221 cacgtcctcg cggatgcggc ctaccaaccc gtctaccagc ccggcgaagc cgaacaccgc
4043281 accggcttgc atgcattcga cggtgttctt gccaaccacc gaacgtgggc gggcaagttc
4043341 aacgcggcgc aatgccgccg agcgggccgc cgcggcatcg gaagacacct gcaccccggg
4043401 cgcgatggcg ccgccaagaa attcaccctt ggccgataca acatcaacac agatcgagga
4043461 tccaaagtca acgacgatgg cggccttccg gaaccggtca taggcggcca aacagttcac
4043521 gatgcggtct gcgcccactt ccttcgggtt gtcgacgagc aaagggatcc cggtgcgtac
4043581 tccgggctcg atcagcacgt gcggcaccga cggccagtac tggtcgagca ttatccgcac
4043641 ctcgtgcagc acggacggga ccgtggacaa ggcggcggta ccggtgagcc gctcggaatc
4043701 ctcgccgatc agcccgtcga tcgtcagtgc cagttcgtcg gcggtgactt cggattcggt
4043761 gcgtatccgc cactgctgca cgacctttgc gtgctctttc attccggaca gcaggcccac
4043821 aacggtgtgg gtgttgcgga cgtcaatcgc cagcagcacg gctatcccac accgagccgg
4043881 gggtctagca gctcgcccgc gttttcgggc acaaatgccg gatcgtggcc catgtcgatc
4043941 ggtttgttgt aagcgtcgac aaacacgatc cgcggctggt atgtgcgggc ccgggcgtcg
4044001 tccatcgtcg cgtacgcaat cagaatcacc agatcccccg gatgcaccaa gtgcgcggcg
4044061 gcaccgttga tgccaatcac accactgccg cgttcgccgg tgatcgcgta ggtgaccagt
4044121 cgagcaccgt tgtcgatatc gacgatggtt acctgttcgc cttccagcag gtcggcggcg
4044181 tccatcaagt cggcatcgat ggtcaccgag ccgacgtagt gcaggtcggc gcaggtcacc
4044241 gtggcgcggt ggatcttcga cttcagcatc gtccgtaaca tcagtttctc caatgtgatt
4044301 cgaggattgc ccggtatccg tccgggcggt cggtgccggc gaaagttccg atttcaatcg
4044361 caatgttgtc cagcagcctg gtggtgccaa gccgggcagc aaccagcagc cgaccggaac
4044421 cgttgagcgg catcgggcca agcccgatat cgcgcagctc caggtagtcg accgccacgc
4044481 cgggtgcagc gtcgagcacc gcacgggcgg catccagcgc ggcctgcgcg ccagccgttg
4044541 ccgcatgcgc tgcggccgtt agcgccgccg agagcgcgac ggccgccgca cgctgggccg
4044601 ggtccaggta gcggttgcgc gacgacatcg ccagcccgtc ggcttcgcgc acggtcggca
4044661 cgccgaccac cgcgacatcg aggttgaagt ccgcgaccag ctgccggatc agcaccagct
4044721 gctggtagtc cttctcaccg aagaacaccc gatccgggcg cacgatctgc agcagcttta
4044781 gcacgaccgt cagcacgccg gcgaaatggg ttggccgcgg gccgccctcg agttcggcgg
4044841 ccaacggacc gggttgcacg gtggtgcgca ggccgtcggg atacatcgcc gcggtagttg
4044901 gcgtgaaagc gatttccacg ccttcggccc gcagttgcgc caggtcgtcg tccggggtgc
4044961 ggggataggc gtcgagatct tccccggcac cgaattgcat cgggttgacg aagatcgaca
4045021 cgacgacgac cgatccgggc acccgcttgg ccgcacgcac caacgcgagg tggccttcgt
4045081 gcagcgcacc catagtaggc accaacatca ctcgccggcc ggtgagtcgc agtgcgcgac
4045141 tgacatcggc gacatccccc ggtgccgagt acacattgag ttcaccggga tggaacgcag
4045201 gaatcgtcat gccgtcaaaa cctcgacgac atccgcgggg gcgtgtgcgc gctgcgcggt
4045261 ccgcagcgcg tttatccggt atgcctgggc cagcgctgcg tcgacgtccg cgagggccgc
4045321 cagatgatcc gcgaccgctg ccgcatcgcc gcgggcgacc ggtccggtga gcgcggcctg
4045381 tccccgctgc agcgtgttct ccagcgccgc tctggccagc ggcccgacga tgcgctccac
4045441 gatcccgccc ggctggtcgt cgacggtttg ttggccgagc agttcccccc cgctcagggc
4045501 ggcccgcaac gcctcgagcg catcggccag cacggtgacg atgtggttgc tcgcatgggc
4045561 cagcgccgcg tggtagagga tgcgggcgtc ttcgcgcaca caaaacggct ccccgcccat
4045621 ctcaagaacc agtgactgtc cgatcgcata cccgacgtcg tcggccgcgg tgatcccgaa
4045681 gcaggtatcc ggcagccggc tgatgtcctc gtcggagccg gtgaaggtca tcgccgggtg
4045741 aatcgccaat ggtatgcagc cctgttgggc tagcggcgcc agaatgccaa tcccgttagc
4045801 tccggaggtg tgcgccacaa tcgtttgtgg ccgcaccgcc gaggtggctg ccaggccgga
4045861 taccaggccg gcgagttcgc tgtcggtgac cgccaatagc agcagctcag cgctggccgc
4045921 gacgtccagc ggtggcagca ccggggtatc aggcagccgg cgctgcgcgc gccgccggga
4045981 cgcatgagag atggcgctgc acgccaccac aacatggtcg gcgcgctgca gcgcgacccc
4046041 tagcgcggtg ccgacccggc cagccgagat gatccccacc ttgagcctgg ccggacgcaa
4046101 accgtcgaac cgctccatag cagacggcct cacaggtttc ttggttcgtt ccagtcccat
4046161 gcccgggtac cggacggtca ccaagactgt agtcgatttg cacgtcaaga cccacccggg
4046221 gcactgctga tttggtcact acaccaacag tgtcggttgc cggcggcaat cgggcgggta
4046281 caccctggca caagcggcgc cgctattcac cgcggcggcg acgccggccg cctccggtcg
4046341 actcgacctg aagcctcgcc ataaggtcgg cgaccgactg gccgccggtt agcgggtccc
4046401 gcgcatgcaa accaccggag tcatccggcg gcgtgtccgc ggtgcggtgc cggcgtgtgg
4046461 gctcagcagg cggcggcggg gccattggag gtgacggcgg acgctcaccc gtcccggcac
4046521 cggagccgcc gatgtcatgg tcgcggtgct ccgccgaatg acgcgaccgg cgaccggatt
4046581 caccgtattg tgccgcgagc tcgacgtagg cgggcggatt gtaggcctgg tctgctgggc
4046641 tggcatgccg ggcgcggcgc cggcgccccg gcggcggggc cgccggcgtg gtttcgggtt
4046701 cgacggatgc ccactggctg ccaggtgttt cggcaggcag ccactgcccg tggctggtga
4046761 ccggctgcca gactggtcgc tcctgttgcg gcgggagcgg cgggggccgg tggcgcggct
4046821 cgaataacgg ctcaggttgc ggcggtggcg gagcctcata atgccgcggt cctccgctca
4046881 ccggtggtac ccccacctcc ggcacatcga tgatcgaggc ctcgtcggtg cggctggcgc
4046941 catcaccccc gcggaccgcc ataacccgat cgctggatac ccagtccgcg ggagggctct
4047001 cgccatcgag ggcacgcgcg gccctggcct ctttctccac ggtccccagc gccggacggt
4047061 gctcgaggtc ggcgtcgaac aaaatctcca ggctggttcg cagcgcggcc agttcggccc
4047121 gcagggctgc tacctcgtcg gcggccggag cgcgcaactc cgaggccagc tcgcggcgca
4047181 gctgagattc cagggtcagc tcgtactccc ggcgcgccga aatctcgcga tccaactgaa
4047241 ggtcatagac cagcttcagg tcacgcaccc gggcctgatc cacgtcgctt tgccggcggt
4047301 aaagcaccga cacaaacgca cccgcgaccg ccgcccacag cgccagcaga acagcgagct
4047361 tgagaagttc cacgcgatcg gtgaaaacca atgcggaact ggccccaatc gccaggacca
4047421 gcaacgccgt caaaagcacc caacccggcc tgcggccgcc gcgccggacc cgggcgccgc
4047481 gggacagaac ggtcatggcc tgactgtacc cgggcgaggt caatccgcgt gtcgcgccgg
4047541 tccggcgatt cccgcatggc ttagccgggt aggcagttcg gccaaattcg ccgcgtagac
4047601 aaccccgcat tccgggtcgg ccgcccggcc agcaacgtcg acgaccgacg cccatcgccg
4047661 gttcggccat ggccgacgca gcgcgcggca ccgtcgggtg tgggctagct ttccgcgccg
4047721 tcggcgtgct cggtcggatc ctgcggagac ttgcagcaat gttgcagcca aagcgcggca
4047781 accaccaacg ctagcgcgct gcccgccgcc accaccgtgc cagtggtgtc ctcggcggcc
4047841 gcccgcagcc atgaccgccg cggcaggaag tacgccagca ccccgatcca ccaccccgtc
4047901 accagcgcac ccacccaggc cgaggccttg gctaccatca agctgcgcgc caccacaagc
4047961 gggtgcagcc agccgggccc gtctccgatc tcgccatcgc tgatcttgac ccgcacgtag
4048021 cgagcccaca acgcctcggc gaccgcgacc gcgagcaagg acaagcccgt ccacaccgtg
4048081 atcggcggaa accaccggta aagcaccgcc accaacagat atcccaccgc cgcggcgccg
4048141 accaccgcgg cggtcagatc acgttttcgg gtcggtccca tcagctttcc ggtgcccgac
4048201 tgacggggtg tctgctattc agatcgaacg acggcctaaa caaccgcaca ctgtcgcggt
4048261 cggcgggctc cagctcggcc agcagtcgcg tgacgggccg cgggcacccg gcaaccgtca
4048321 gctgcgccgt tgggtcgacg gcaatccacg ggatcaacac aaaggcccgc agatgcgcca
4048381 gtgggtgcgg cagcgtgagg tggttctccc gcgcggtcac ttcgaccaga gcctcggtgg
4048441 ccgaggtctg gtagcaggcg atcaggtcga cgtcgagatt tcgtggaccc cagcgctggc
4048501 cacgcaccct gcccgcagcg cgctcgaact cctgcgcccg ccgcagccac tcccgcggtt
4048561 cgcaggtagg atcgtcggcg atcagcaccg cattgaggaa ctgcccctgc tccaccccac
4048621 cccaggggtc ggcctcatat atcggggaag ccgcaatcaa cgcatcgccg agaccgtcgg
4048681 cgaccgaccg caatcgtgcc aggcggtcac ccaggttgga gccaaccgag agcactaccc
4048741 gcgtcatacc gcgccgcccg ccgggactac ccaaccgcgg ccgccgcgcc gtgagcgtcg
4048801 gatcaccacc gccacatcgt cgaacgtctg cggaatgggc gcctgcggct tgtgtaccgc
4048861 cacctcaacg gcatgcactc gctggtcgtc catcacgtga tcagcgatct cggccccgac
4048921 cgtttcgatc agcttccgcg ggggtccggc gacgatctcg gccgcccgcg aagccagccg
4048981 cacgtagtca taggtgtcgg ccaagtcgtc gctgttggcg gcctcggcca ggtctatcca
4049041 cacggtgaca tcgatgacaa accgctgccc ggccactcgc tcgtggtcgt agaccccgtg
4049101 ccgaccatgc acggtcaggc cgcgcagttc gattcggtca gccatcgcgt tctatccttt
4049161 ccgctcccat ccacgcttcg accaccttga tggcatcgac cgaggcccgc acatcatgca
4049221 cccgcacacc ccaggccccg tgcagtgcgg ccagcgcgga aatcaccgcc gtcgcggtgt
4049281 cacgcccatc ggttggccgc atcacgccgt cgggcccggc caacaacgca ccgaggaagc
4049341 gcttgcgcga agcacccacc agcactggga ttccggtcgc gaccagttcc ggaagggcat
4049401 gcaagatcgc ccaattatgt tgcgccgtct tggcgaatcc aagcccggga tcgagcacca
4049461 gccttgccgg gtcgacgcct gcggccaccg cgtcggcgac gctggccagc aggtcggcac
4049521 ggacctcggc caccacgttg ccgtagcgca caggcacatg cggggtatcg gccgataccg
4049581 cccgccagtg catcaacacc cacggcacat cggcctcggc caacagcggc cccatcgccg
4049641 gatcggcccg cccacccgac acgtcgttga ccatctgggc accgttctgc aacgccgccc
4049701 gagcgacatc cgcgcgcatg gtatcgatgc tgacggtgat gccttgtgct gcaagctctt
4049761 tgacgacggg tatgacacga gacgtctcca ccgccgggtc aacccgagtg gcaccgggcc
4049821 ggctcgactc accaccgacg tcgacgatgc ccgcacctgc ggctgccatc gccagaccgt
4049881 gcttcaccgc atcgtcgaga tcgagataac acccgccgtc cgagaaagag tcgtccgtga
4049941 cgtttagaac ccccatcacc tgcacgggcg ccggactcac ttccgcaaaa tgaggtcgag
4050001 cgcttcggct cgagaagcgg cattggtttt gaacagtccg cgcaccgccg acgtagtggt
4050061 gaccgagccg ggcttgcgaa ccccgcgcat cgccatgcac agatgctcag cctcgatcac
4050121 cacgattacc ccgcgtggat cgagtttttt catcagggca tcggcgatct gactggtgag
4050181 ccgctcctgg acctgaggtc gcttggcgta cagatcgacc agtcgcgcga tctttgacaa
4050241 gccggtcacc ctgccgtcgt cgcccgggat gtagccgacg tgggccacac cgtggaacgc
4050301 caccaggtgg tgttcgcagg tggagtacat agggatttcc ttgaccaaca ccagctcgtc
4050361 gtggtcttcg tcgaacatgg tgttcaacac cgagtcgggg tcggtgtaga gcccggcgaa
4050421 catttcgcgg tatgaccggg caacccggga cggggtggct accaagccgt ccctatccgg
4050481 atcctcgccg atcgcgtaca gcaattcgcg caccgcggcc tcggcacgtt gctggtcgaa
4050541 cacacggata cgagcagatg cgctgcgcga atccagctgc gacatcgaat gctccgttcg
4050601 tcagccgtgg gccggcttgg tccgactgac ctcgtcatcc tgctccgccg aggactcatc
4050661 ggaacccgga tcggcttgac cggtcgggta gggctgaccc ggatacgtcg gtgccggttc
4050721 accgctatag ctgggccgat gagatgacct tgggggccat cccggcgcat gccagcccgc
4050781 cggggcaccg tagtcaggct gggtggagcc gtactggcgg tcaccggacc ggtgggtgcc
4050841 ggcgggcgaa ccgttggcgc cgtgcccggt ttggccggcg tcggaccggg cggcctcagc
4050901 ggcttgggta gcctgcgcaa tcgccgcctt gaacgccggc tcggggaccg gctggggcca
4050961 aggttcgccg cgttcgatcg cgagctcgcc gggtgtcttg atgggcggtt tgtccgacgg
4051021 gatccggcca ccgaagtcgt cgaacatggt gagccgcggc cgcttttcga cgtcagcgaa
4051081 gatgctttcc agctcgggtc ggtgcagggt ctccttttcc agcagctcgc cggccaaagt
4051141 gtccagcacg tcgcggtatt cggtcaggat ttcccacgct tcggtatgcg ccgcctcgat
4051201 aagcttgcgg acctcttcgt cgatctcgcg ggcgacctcg tgggagtagt ccggctgggt
4051261 gcccatggta cgtccgagga acgggtcgcc gtgttcggag ccgtatttga ccgcgcccag
4051321 cttggagctc attccaaatt cggtgaccat tgagcgcgct atcttggtgg cctgctcgat
4051381 gtcggacacc gcgccggtgg tcggctcacg aaacaccagt tcttcggcgg cgcgcccacc
4051441 catcgcgaac accagttgcg cgatcatttc cgagcgggtc cgcaggccct tgtcttcttc
4051501 cggcaccgcc accgcgtgcc cgccggtacg cccgcgcgcc aggatcgtca ccttataaat
4051561 cggctcgata tcgggcatcg cccaagcggc cagggtgtgc ccgccctcgt gataggcggt
4051621 gatcttcttc tcctgctcgc tgatgatccg gcctttgcgg cgcgggccgc cgatcacccg
4051681 gtccaccgct tcctcgaggg cgggaccggt gatgacggtg ccgttctccc gggcggtcag
4051741 cagcgccgcc tcgttgatga cgttggccag gtcggctccg gtcatgccga cggtccgctt
4051801 ggccagtccg tcgaggtcgg cgtccgcggc catcggcttg cccttggagt gcacgcgcag
4051861 caccgcccgc cgacccgcca gatcggggtt ggataccggg atctggcggt cgaagcggcc
4051921 cggccgcaac agcgccgggt ccaggatgtc gggccggttg gtggccgcga tcaggatgac
4051981 gccggcgcga tcgccaaaac cgtccatttc gactagcaac tggttgaggg tctgctcacg
4052041 ctcgtcgtga ccgccgccca gcccggcgcc tctttgtcgg ccgacggcgt cgatctcgtc
4052101 gacgaagatg atgcacgggc tgttctgctt ggcctgctcg aacaggtctc tgacacggga
4052161 tgcgccgacg ccgacgaaca tttcgacgaa gtcggagccg gagatggtga agaacggcac
4052221 tccggcttcg ccggccaccg cacgagccag caacgtctta ccggttcccg gcggcccgta
4052281 gagcagcacg cctttgggga tcttggcgcc cagcgcttgg tacctgctgg ggttctgcag
4052341 gaagtccttg atctcgtaga gctcctcgac cgcctcgtcg acacctgcga cgtcggcgaa
4052401 ggtggtcttg ggcatgtcct tgctcagttg cttggcgcgt gacttgccga acccgaagcc
4052461 catccgggcg ccgccttgca tgcgggagaa catcacgaac agccccacca gcaacagcag
4052521 cggcagcacg tagaccagca gctcgcccag gatgctgccc tggttgacga ccgtgctgac
4052581 cttcgcgttt ttggcgctga gcgcgttgaa caggtcgacg gcgtacccgg tggggtactt
4052641 ggtgatgacc ttctcggacc cgtcggtctc gttgttaccc ttcttcagga tcagccgcag
4052701 ctgttgctcg cgatcgtcga tctgtgcgct cttgacgttg tcgccgttga tctgtgttat
4052761 cgccaccgag gtatcaacgg gcttgtagcc gcgggtgtcg tcgctgaagt aaaagaacga
4052821 ccagccgagc agcaccacga cggcgatcgc tgttatggtg cgagtcacgt ttttccggtt
4052881 catcgatcat cggccgtgcc ggccaggtcc ttcccgatac acgcagctgg aaagtccagg
4052941 ttaccgctcg tggcgatcgc aaacccggcg gagccgggtg cagcgggtcg ccaccatcag
4053001 ccccgtggcg atcgcaaacc ccgcgcctgg cgacaatgcg gcccgcaaaa cgggccgagg
4053061 aggagccagg caatcacccc agagccgggt gcagcgggtc gccaccatca gccccgtggc
4053121 gatcgcaaac cccgcgcctg gcgacaatgc ggcccgcaaa acgggccgag gaggagccag
4053181 gcaatcaccc cagagccggg tgcagcgggt cgccaccatc agccccgtgg cgatcgcaaa
4053241 ccccgcgcct ggcgacaatg cggcccgcaa aacgggccga ggaggagcca ggcaatcacc
4053301 ccagagccgg gtgcagcggg tcgccaccat cagccccgtg gcgatcgcaa accccgcgcc
4053361 tggcgacaat gcggcccgca aaacgggccg aggaggagcc aggcaatcac cccagagccg
4053421 ggtgcagcgg gtcgccacca tcagccccgt ggcgatcgca aaccccgcgc ctggcgacaa
4053481 tgcggcccgc aaaacgggcc gaggaggagc caggcaatca ccccagagcc gggtgcagcg
4053541 ggtcgccact ggctagacca acgaccggta gttcccgacg gcgtcggaaa atccgacagc
4053601 tgagcgttcg ggtcaaacac gcggtgcacc ggacctgatt tggctcgaat tggtgcgcac
4053661 cgagggtcgg gcacatcgct ccggtcgcat gtgtcactgc accgggcgac acccgatctg
4053721 cccagctctc agcgacagct gcctgacctg cggttttgtt cacaagttgg ttgcggctgt
4053781 gcgggattgt aggcggcgtt gaccggcaga aaccgagttg tcgcgcatag gtgagcacag
4053841 cgaccatcgc ccccggtgga gtccagtgtt gcggacgtga ctaaagagca gcacgggcag
4053901 cgggagcaga actcgggtca attgagtcat ccagcgcgcg aacgtggttc ggcgcagccc
4053961 cggttggctg tctgggcgtg aaggtgctcc cgagcggccg gcccgccatg aaggcgcgcc
4054021 aaagctttgg cattgtgcac attttccacc cgtgctctat taatgctgag ccgcgaattg
4054081 tgagcccagt cgggaaacac gcggagcacc agagtcaccg cagcggccgg ggcggttcaa
4054141 ctcaccatgg atcgctctcg tcgtctggtg ctggacaatc gtcgctgtag cgcgtcgcga
4054201 acacctcagc ttctgctgcc gcggcttctt ccggcgatgg taacccccag gtttcgccca
4054261 cggtcttacg tagcagtgcg acgcggtgtt catctgcatc gacctgttga ctcatcctgt
4054321 caaggatgaa ggcgtactgg gccgactgcg ccttctgccg cgccaggtcg gcaatcacca
4054381 ggatctcaga agcgagctgc gactcactca tccaggccac cctggccgac agctcgacat
4054441 ggtcaatccg gccgtccatc agcgtcgata ccgacaccgt gcgtggggga ttcgtcacgg
4054501 taaaaagcgc gatctcttgt tcggtgtccg tctccgcctg accgtgggca ttgtccaggt
4054561 cgggtccggt gtccggggtc gccgccgacc cgacgccaat aatcggatcc gcagtccagc
4054621 cctccgcgcc gtcggcaccc cagagatcca cggcgtcgaa atcgttgctg tcaaagtcat
4054681 ttccgggcaa gtccaccgtc ccttcggaat tcattgccac ccgggaaggg tcggcctggg
4054741 cagctggcgt ggtcagtccg aacaggtcgt tgggaagacg ctgtggcctg cactgcgggc
4054801 agcaaacgtg gtcaggtaaa caacccgtcg atagccttgc gccacgcttc gtcggcctcg
4054861 ctatatatct tcgccgcaat tcgaagactt ttggcgagat cgacaccggc cgtatgcaag
4054921 gacgagccca gggcattgtg ggcagtcaag tacacattta acgtgtcgtt gaactgtgag
4054981 cagtacggac cgtgagtgat cgccacagat tcgcctaggc cagcggcagc ttcgacgccc
4055041 gaggaggcat cgaccgccgc gttgtcatgg tgcgacgcca gtacaccgag acgctcgggc
4055101 tggacggtca agttttccgt cattgatcgt gtcccttccg tttagcattg cgcgttgtta
4055161 ggcgctggct agcaatggat ttggctcgcc atgccgttag acgacgtttc gtaccagcac
4055221 cttttgccca ccgcccgcgt cagcttcgac tggcgcgcgc tcggcgtctt cagtgcccgc
4055281 cgccgcgcct tccgagtact tcttcgtcgt cgtccctttc gacgcccccg aagaggggtg
4055341 catgccgccc atgcctacgg gtccgcccat accttgggaa ccctgcgcgg agaccagctg
4055401 cgactgcccg ccgacctgct cggcagcggc gccgaccggg ccatcagctc ggggccgtag
4055461 cgcctgccga gttgaggcgg catggacctg agccaggctc ggcaagcccc caaaaccgga
4055521 cccgccccca atgccggcca gggcgggcaa gctggctgag ctcgccaggc tatccgcgtg
4055581 agccaagccc gacgatgcgg acagaccggc cgcaccgaac aagccagtca cttgcgacaa
4055641 gccgctggtc gcgccggtca agccggggac gcccgcaaag aaggactcca ggttcgacca
4055701 ccctcgagag aacagtccgg tcacccaccc cgtgagcttg tcccaaagct ctttcaggcc
4055761 gttgagcgcg tttgtgatga actcccacac ttctccgagg gtgcccttga tgatgtccgc
4055821 cacatccgaa atgatgtccg caatggcggc cgcgaccaac tccgccaatt tggcaagcaa
4055881 tttgaggagt tgagtcgcgt tgatcagcgt tttcacgacc aagtaggcaa gcgcgccgcc
4055941 cactacggcc atcgcgcccg cgcaaaacgg cgcctggaag gcggccgata gggcgtgccc
4056001 gacgaccggg atgtaggtca ggtccacagc caccgggcgc acgaactcga gacctttctt
4056061 ggcgccctcc aggatgtcgc gggtcgtctg gaccgcgttg gcctggtcgt ggatcaggct
4056121 gatgagctga cgatcgaggt ctgccagttc ctggaaaaaa ttcacgtggt tgcggttttt
4056181 gccggcgtat ttgtccgcgg ccgaacctaa ccagccatca cccggaaacg ctgctgccag
4056241 ctcctccagg gctttttcga agtactctag tgaggagtaa aggatacccc cttggttggg
4056301 tattccaatc cccagaaggt cgtacaagcc gtcaatggca ctgatcgttg gatcgatgat
4056361 gaacgctctg ctcatgcctg ccgcctatct caacggtcgt cgattccatg catagccttg
4056421 gttctgcatt gcacgcgtag ggcctacagt ctggctgtca tgcttggccg atgtcaacag
4056481 tttttttcat gctaagcaga tcgtcagttt tgagttcgtg aagacggcat gttcacttgt
4056541 tgtcgactac atcgtctgcg cacatttgcc ctcctgcaac tgcgctgcga caatgcgcca
4056601 accgccgtgt aggcggcgcg atcccaaggc agtgtctccg acgtcgatgc ctgcgcttcg
4056661 ccttcgatcg gtatgagatc tgttgcagga gagtctatat agtgtgctca tggggctagc
4056721 cggcggcggc ctcgtggcgg gcacaatcac ctcgccggtg gcgcaatcag ggctgtgcta
4056781 acccaccatc actcacccga ttcggcgtcg aagcggggcg ctctcatggt tgcgaggcaa
4056841 agcaaatctc ggttgtccta aatcgcgtcc gctaaacacc tagctaggcc gatctgtcat
4056901 tatctccgat catgtttgat aaggcgacga aaaccgacga tggaaatccg ttgcgctcgg
4056961 caagatcggc gaagtattgc ggcggcctta tctaaaccac tgaagtttta gtaattatcc
4057021 gtccgagata tccgaatata gcgaacaccg gtaccttgcg aagaaaagcc tgaatctgat
4057081 aacgccgata tccactcggg agttatcggg caacggaaag cgaaacggcc tccgtcggag
4057141 agcgactggg atagccctgg ttccgggtgg tttgctatcc cgggataacg gcagtgctac
4057201 atgctcggac cgatttgcga tgcagcccca ccaatgcggt gtctcgcctt agtagacacc
4057261 tgccgaggat gggttacatg gtggtcagct actgagccaa ccggtcgcac ggcgagccgt
4057321 atcaagatca cgccaagaca gcggttaatt ctatcagcaa atgtttctat aggactctat
4057381 agcccgcctg agctattccg gtgctgtcgg ctaagcctgt gaccggtgtc actgcagcaa
4057441 gccatttcac cgattggctc acgtttggga ccctcgactg actgcggttg gttgacctgc
4057501 tgcttttgtc cgcgaattca ccggaatttg aactggacct ggccggcaat cgtggggcag
4057561 tcactgtgag ctgtagccat gccagctgca caggaagtgc gatccggacg tcaagggagg
4057621 cccgactggt ccggccggcc gatcaatgat gcgcggcagc acccgcgaca atcgcctctg
4057681 gctgctcccc aagcccttct caggccggtg cccggtgtga tttggtgaga cgatgggcgc
4057741 acctaccgaa cggttagttg ataccaacgg cgtgcgactg cgagtggtcg aggccggtga
4057801 gcccggcgca cccgtggtga tactggccca cggctttccc gaactggcct attcatggag
4057861 acaccagatt cctgcgcttg ccgacgccgg ctaccacgtg ttggctcccg atcagcgcgg
4057921 ttacggcgga tcgtctcgcc cagaggcgat cgaggcctac gacattcacc ggttgaccgc
4057981 tgacctagtg ggcctactag atgatgtcgg tgccgagcgg gcggtctggg ttggtcatga
4058041 ctggggtgcc gtggtggtgt ggaacgcgcc actgctgcac gctgaccgag tcgccgccgt
4058101 tgccgcgttg agcgtccccg cgctgccccg ggcacaggtg ccgccgacgc aagcgttccg
4058161 cagcaggttt ggggagaact tcttctacat cctttatttc caggagcccg gcatcgccga
4058221 cgccgaactc aatggcgacc cggcccgcac gatgcgccga atgatcggcg gtctgcgccc
4058281 tccgggcgat cagagcgcgg caatgcgtat gctggcgccc ggccccgacg gctttatcga
4058341 tcggcttccg gagccggccg ggttgccggc ctggattagt caggaggaac tcgaccacta
4058401 catcggcgag ttcacccgca ccggtttcac cggcggcctg aactggtacc gcaacttcga
4058461 ccgcaactgg gagaccacgg ccgacctcgc cggcaagacg atctccgtgc cctcgttgtt
4058521 cattgcgggc acagccgatc ccgtcttgac gttcacccgc accgaccgcg ctgcggaggt
4058581 gatctccggc ccgtatcgcg aggtgctgat cgacggggcc ggtcactggc tgcagcagga
4058641 acgtcccggt gaggtgaccg cggccctgct ggagttcctg acggggttgg agttgcgatg
4058701 aaggcaccgt tgcgttttgg cgttttcatc acgccattcc atccgaccgg tcaatccccg
4058761 accgtggcgt tgcaatacga catggagcgc gtcgttgcgc tggaccggct cggctacgac
4058821 gaggcgtggt ttggcgaaca ccactccggt ggctacgagc tgatcgcttg cccggaggtg
4058881 tttatcgcgg ccgcagcgga acggaccacc cacatccggc taggtaccgg agtggtttcg
4058941 ctgccctacc atcatccgct aatggtggcc gaccgttggg tgctgctgga tcacctgacc
4059001 cgtgggcggg tcatgttcgg caccggcccc ggcgcgctgc cgtcggacgc ctacatgatg
4059061 ggcatcgatc cggtcgagca gcgacgaatg atgcaggagt ccctcgaggc gattctcgcg
4059121 ctgttccgtg ccgcacctga cgagcgaatc gaccgccact ccgactggtt caccctgcgt
4059181 gaagcgcaat tgcacatccg cccctacacc tggccgtacc ccgaaatcgc taccgcagcc
4059241 atgatttcgc catcgggtcc gcgactggcc ggtgcgctgg gcacgtcgct gttatcactg
4059301 tcgatgtcag tgcccggcgg ctacgctgcg ctggaaacag cgtggggcgt ggtgcgggag
4059361 caggccgcca aagctgggcg gggcgagccg gatcgcgccg attggcgggt gttgagcatc
4059421 atgcacttgt cggacagccg cgaccaggcg atcgacgact gcacttacgg gttacccgac
4059481 ttctcgaggt acttcggcgc ggcagggttt gtcccgttgg cgaacaccgt ggaaggcacc
4059541 cagtcgtctc gggaattcgt cgagcaatac gcggccaagg gaaattgctg catcggcacg
4059601 cccgatgacg cgatcgccca cattgaagac ttgctgcacc ggtcgggtgg cttcggaacg
4059661 ttgctactgc tcggccacga ctgggccccg ccaccggcaa cctttcactc ctatgagctg
4059721 ttcgcccgtg ctgtgattcc ttatttcaag ggacaactcg cggcgccgcg ggcgtcgcac
4059781 gaatgggcta gaggcaagcg cgaccaattg attggccgcg ccggcgaagc ggtcgtcaaa
4059841 gccatcaccg agcacgtcgc cgaacaaggg gaagcgggca gctgacgcgg gcgcagtgtt
4059901 cccaacgacg acatgcccgt gtatcgggcg ccaaagtcga cgctgatcgg cccgccctgc
4059961 gcggacccaa cttaggaccc gggttaggcc cagctggagc cgacggcgct gtcggtttgt
4060021 gccatgttgt tgccggcagc ctgcaccttc tgcccgtggg cgttggcctg ctcgtagatc
4060081 acctggaagt tacggcccag ctgggtaatg aacccctggc aggccgccga accggcgccg
4060141 ccccaaaagt cactcgcggt caacacatca gaaatgatgg cctgatgctc ggcctccagc
4060201 gacccggcct gagcgcggat catggcgccg tgagcgtcga cgtccccgaa ttgatagttg
4060261 atggtcatgt gtcctcctga gtcgtcgggc cgggtcagct gctgaggatc tgctgggagg
4060321 cctgctcttg ctgttcgtag ttgttggcgt cgcgaaccag cccgtcacgc accccgtgca
4060381 gcatgttcac gatgttgcga aacgcctgat tcatctgggt catggtgtct agcgaggtcg
4060441 cctcggccat gccactccag cccgcgccgg aaatgttttg cgcggacgcc cacatccggc
4060501 gagcctcgtc ctccaccgtc tgggcgtgca cctcaaaacg gcccgccatg tcccgcatcg
4060561 cgtgcggatc cgtcataaaa cgcgaggtca tatgaattcc tccctttgaa tcgtcgaatt
4060621 cgatcctcga tcaacgaacg tagttggtca tccgccagcc ggcggttggg cgatcacggt
4060681 cggcttgaat ccgtatcgag gggcagcgaa gttgttaaac gcacgtccgg caccgctacc
4060741 catgagcggc atcccgccaa acgcgtgtgt cgaaccttca gcggcggccg cggctccgag
4060801 gccgttggac gccgccagca ccgcggggct cgccgccggg gtcgtggcgg tccaaacggc
4060861 cggaaccttc aatcccccga ccgacgccgc ctgaccgacg gcgcccgcaa cgccgctcag
4060921 gccagcactc ggaatggccg gaacggcggc cggcaacgcc ttggcggcct caccggcggc
4060981 tttggcgcct tcactcgccc acttcggcag gtcgtgcgcc aggccaaagt agtccttgaa
4061041 ttgggtgacc atgagccgag cgggcgagac ccatttgccg aacgtgtcca tggccacgct
4061101 ggcatcaagt tcggccgacc cggtcacacc ctgcacaaag tcgccaagca ctccgcccac
4061161 gatgagcccg ctaccgtccg aggaccaggt gtgcccggtc aaaccgagcg ccttgccaag
4061221 gtcggtgagc caaggcggtt cattggtgaa gattccgcta agcccaaaca acgctttagg
4061281 aatgtcggtg agtgcttgcg catttgcggc cccgctgaca gcttgtccga cagatgcggc
4061341 ctggctggcc agcccggccg ggttgatggt ctgcgccgcc ggattgaatg gcgacaactg
4061401 cgtcgccgcc gccgacgcgc cagcatagcc gtacatcgcg gccgcatcct gggcccacat
4061461 ctcggcgtat tgcgcctcgg tggccgcgat cgccgccgtg ttctggccaa ggaagttcgt
4061521 cgccagcaac gccatcaaca acgccctgtt ggccgcgatc tccgggggcg gcacggtcgc
4061581 gaaaaacgcc gcctcataag cactcgccgc tgccaccgct tggctgccgg cttgctcggc
4061641 ctgcccggcg gtgctcctca accacgccac ctggggcgtg gcggcagcca ccatggacgc
4061701 cgcggaggac ccctgccatg gcccgtcggc caggccagtg atcagagcgt cgtaggtgga
4061761 cgccgtggtt tgcaactcgg cggccagcgc ctcccaggcc gccgcggcag ccagcatcgg
4061821 tcccgaaccg ggtccggcgt acatcagcgc ggagttgacc tccggcggta actgagcaaa
4061881 gtccagcatc ggcctctcct aagcgatcgt ggcggcgttg gcagcctcgg tggccgcata
4061941 tgaaccggcg ctgatgccca gcgtggtcgc caactgctcc tggaccgcca tcgcctcggc
4062001 actaatcgcc tggtacagct gtgcatgcgc ggcaaactgg gaggcggtta gcagggacac
4062061 caaatcagcg gcggccggaa ccacacccgt cgtcgggccc gccaccgctg catttccggc
4062121 ccgcgcaacg gcgttgatcg actgcagttc ccccgcggtc gcagccagca tctctggctc
4062181 ggcgtgcatg atcgacatgg tattttcctc cctctaatgc acgttgcatc aatagctttc
4062241 ggcgttcccc gctgaagacc acacgacagg ctagccatcc ttataggaac atcacagact
4062301 tcacacaggt tgttcacggc taagtcaata acaattcatt tacttcaagg gcatttccgt
4062361 agcttttgaa attcccctga aattcattgg taacaagtaa tttgagtttg gtatgaattt
4062421 cggggtactg gcatcgacgg gccctacaat gcgcaacttg cgcacaccac gccacgctga
4062481 agcaaccgtc gaccgattca acggcgcagg cgctagggtc ccaggcatga tccgattggt
4062541 ccgtcattcg atcgccctgg tggccgccgg ccttgccgcc gcattgtcgg ggtgcgattc
4062601 ccacaactcg ggatcgctcg gtgccgatcc gcggcaggtg accgtgttcg gatccgggca
4062661 agtgcagggt gtgccggaca cgttgatcgc tgacgtcggc attcaggtca ccgcggccga
4062721 cgtcaccagc gcgatgaacc agaccaatga tcgccagcaa gcggtgatcg atgcactggt
4062781 gggtgccggc ctggaccgca aggacatccg caccaccagg gtcaccgtgg caccgcagta
4062841 cagcaatccg gagccggccg gaaccgccac catcaccggg tatcgggcag acaacgacat
4062901 cgaggtgaag atccacccga ccgacgccgc gtcgcggctg ctggccctcg tcgtcagcac
4062961 cggcggtgac gccacccgga tcagctcggt cagctactcg attggcgacg actcgcagct
4063021 ggtgaaggat gcccgggcgc gcgccttcca agacgccaag aaccgtgcgg accagtacgc
4063081 acaactgtcg gggctgcggc taggcaaggt gatctcgatc tccgaggcat ctggcgccgc
4063141 gcccacgcac gaggcgccgg cgccgccgcg cggcctatcc gcggtgccgc tggaacccgg
4063201 ccagcagacg gtgggcttct cggtcacggt ggtctgggaa ctgacctagc cgcctactga
4063261 tagaccctgg ggtccagcgt cccgatgtat gacaggtcac ggtagcgttc gtcgtagtcc
4063321 aggccgtagc ccacgacgaa gtcgttggga atgtcgaaac ccacgtacgc gatttcgacg
4063381 ttggcgtgca ccgcatcggg cttgcgcagc agcgtgcaca cccgcaatga ccgcggattc
4063441 cggctcgtca ggttccgcga caaccacgaa agcgtaaggc cggagtcgac gacgtcctcg
4063501 acgatcagca cgtcgcggcc gtggatgtcg cggtcgaggt ccttgaggat ccgcaccacg
4063561 cccgacgagg atgtcgatga cccatacgaa ctcaccgcca tgaactcgaa ctgggtcggc
4063621 acgggaatcg ctcgcgccag gtcggtgacg aagagcaccg cgcccttcag cacggtgatc
4063681 agcagcagat cctggccggt ggtagcggac agctcgcggt agtcgttgcc gatctgctcg
4063741 ccgagctcgg cgatgcgggc ctgaatctgc tcggccgtga gcagcaccga cttgatgtcc
4063801 cccggataaa gctccgccgt ctgcccgggg gtgatcgccg aggagctctg ggtcacgtgc
4063861 acagcgtgcc acgccgcggg accaacgacc aacgcgggcg tcaaacgggc tcgcgccgca
4063921 acacaagtac gccgtcgcgc cgcccggcga ccagtcgctg accgcgcaac gtggacccaa
4063981 ccgctacccc gccctgaccg cgccacgcgg tgaccagccg gtccactccg cggatctgcc
4064041 tgtcggtcag tccggtcgcg ccgccggcca gcagccagcc ccgaatcacc cggcgccgca
4064101 ccgcatccgg cagcgcggtc aaggcgctgg tactcaactc ctgtccccgt gagccagcaa
4064161 cagcggctcc gggcagcgcc tgcgcagcga tcgtgtcgat gaggtcagtg tcctcgcgca
4064221 acgctgtcgc ggtgcgagcc agcgcttcgg ccacacctcc gcccagcacg tcctccagca
4064281 gtggcagcac ttcggtgcgc aatcgggttc gggtgaagcg gcggtcggtg ttgtgcggat
4064341 cctgccaggc ggtcaggccc agctcccggc aggccgcatg tgtcacgctg cggcgcaccc
4064401 ccagcagcgg ccggcaccag ggcggatcgt acggacgcat gccggcgatc gaccgggccc
4064461 ccgaaccacg gccaagcccc aacaacactg tctcggcctg atcatcgagc gtatgggcca
4064521 acagcaccgg gccatcgcgg tgctcctcca atgccgagta gcgggcgctg cgcgccgccg
4064581 cctcccggcc gccggccgcg cccacctgaa cgcaaagcac ccgcgcgtcc acacatccca
4064641 gcgaaatcgc ttgtatgcga gctgtttccg cgaccgtggc cgagccgggc tgcagaccgt
4064701 ggtccacgat cagtgcggtg gtgggccaca gccgtgcggc tacagcggtg agcgccaacg
4064761 agtccgggcc gccggagagc cccacgctcc aacggtcgca ggcgtcgaga tggacccgag
4064821 cgaactgctc cgcagccgca cgcagctgcg ctacagcact ctgtcgatcc atcgctgcgg
4064881 gttttcgatc tcggcaggca acggcagcgt ctcggggccc gaccagatcg tgttgaacag
4064941 cttcattccc gcccggtcga ccacatggtc gacgaatgcc ttgcctcggg tgtactggct
4065001 gagcttggcg tcgaagccca gcagagctcg caccagccgc tgcagcggcg gctgtttgtg
4065061 atgacgacgg tcgtcgaagc ggcggcggat ggtggccacc gagggcacca ccatcggccc
4065121 gaccgcatcc atcacatgct cggcatggcc ttccagcagc gtgccaagta ccagcagctg
4065181 gtctaaggcc ttacgttgcg gctcggattg cacggctcgc accaggccca gaatgcccga
4065241 cgggttgacc tcggaatcgt cggtaccgtg tccacggctg cggatgaagt ccgccagccg
4065301 gctcaccacc cgcccgatgt cgtcaacggg ttcgaaggtc aacaggttta gcgcctgcga
4065361 catgtagccg gacagccagg ggttggcggt gaactggact cggtgggtga cctcgtgcag
4065421 gcacacccac aaccggaaat cggacggctc gacccgcagt tgacgctcga cggcgatcac
4065481 attgggatat accagcagca agcagccttc tccggcggct ccgaacgggt cgtactggcc
4065541 gaggatgccc gaggccacaa acgccagcac ggcaccggtc tgcgcaccgg tgatccgacc
4065601 ggtgagaaac ccccgcggtt tggcgcttcc gtgcgtcatc gcccgcatcg attcggcggc
4065661 cgagcgaatc cacgccggcc ggtcgacgac acgggccggc ggcaccacac cgtcggcgat
4065721 cagaccggtg acgtcgcgca ccggcggttc ggccttctcc gccgcgacgg tcagctcgtc
4065781 gatcacctgg cgacgggtgt attcggtgga cggcggagcg ggccgggcca gccgctcccc
4065841 gacgctggcc gcaaattccc aatcgaccgt gttccccagt gtcagctcgg acgctccggt
4065901 cacgtcgtgc acccgcagaa ccacaactta gtggccagag cgtccatcgc gttgcgaccg
4065961 ttgggaccgg cttcgttgga gatgaacgcg aaggtgagca ctcggccgct acggtcggtg
4066021 agcaccccga ctagcgagtt gatcgcggtc agcgagccgg tcttggcccg caaccacccg
4066081 gccggaccct ggtcggtggc cgcgtcgagg aagcgctcgc ccagcgtgcc actgccaccg
4066141 gcgatcggta gcagatccag cagcggccgc aacgcgggct ggtcgggtcc agccgcggcc
4066201 tgcatcgttg catcgagcgt ccgagcggtc aggcggttgt cgagcgacaa tccactagaa
4066261 tccaccagcg cagcgccggc ggtgtcgatg tgtgcggtgt tcaatcggct ggtcaccgcg
4066321 tcgaccgcgc cactaaagct ctgcggccgg ttgatcgcga ccgctacctc gcggccgatg
4066381 cactcggcca tcacattgtc ggaggcgttc atcatctgag acagtcgctg gatcaacggc
4066441 gccgactgca ccacggccag ctgccgcgcg ccggccggag ccgatgcgat cgtcaccgcc
4066501 gcggggtcca ggccaagggc tttggccaac tcccgaccgg catccagcgc cggggtgcgg
4066561 gaccgtctcg aattgacggt ggtcggctgg atacgcccgg cgtcgatcat cgccgcttcg
4066621 atcggcgcga tgtcaccgtt gtcgatatcg gccggatccc aacccggcgc catcgtcgga
4066681 ccgctaaacg ccgaagcgtc cacctgcacg gcggtgggcg tcacaccgct gcggcgaatt
4066741 tgttcgacga ggtcaccgat gcgagccgcg ccgtgatacc aggtgtcctg accgggcggc
4066801 gctgccgaca gcgtcggatc gcccgcgccc accaacacga caggtccctg ggggttctgg
4066861 ccgccggcca ccacccgcgt gctgatccgg gcctgtcggt ccagtgtcag cagagccgcc
4066921 gccgccgtca ggattttgtt ggtcgaagcc ggcaccaagg gcacgtcgtc tagccgctgc
4066981 caaagttctt gtccggtcag ggcatcggtg atccgacctg ctaacttgcc cagatcagga
4067041 tcggccgcca ccaccgcaag cgccgcggtc acgccagcgg cactcggtgt cgcagcggtg
4067101 tccgccacag ggaccactcc cgccttgact gtgggtggcc gcggtggagg cgcaggtgcg
4067161 cgcacgccag cccggtgacc accagtagtg accagcgctg cggccgccac cacaacggcg
4067221 acaaacgcca gcacggccgc gccgacgacc acgtgcgtgg atttccgcca gcgtgtggga
4067281 cccatgagct ctcctgcctt tccggtccca ttctgccgaa ccggccgggc gacgctgcca
4067341 cggtaccggc tcgactaggg tgtccacgga cgcattggac ctgcccgttg tcccatgcac
4067401 tctgatctga aggagccgac gcgtgcaatt cgacgtgacc atcgaaattc ccaagggcca
4067461 gcgcaacaaa tacgaggtcg accatgagac ggggcgggtt cgtctggacc ggtacctgta
4067521 caccccgatg gcctacccga ccgactacgg cttcatcgag gacaccctag gtgacgatgg
4067581 cgacccgctg gacgcgctgg tgctgctacc gcagccggtc ttccccgggg tgctggtggc
4067641 ggcgcggccg gtggggatgt tccggatggt cgacgagcac ggcggcgacg acaaagtgct
4067701 gtgcgtccca gccggtgacc cccggtggga ccacgtccaa gacatcgggg acgttccggc
4067761 tttcgagctg gatgcgatca agcatttctt tgtgcactac aaggacctgg aaccaggtaa
4067821 gttcgtcaag gcggccgact gggtcgaccg cgccgaagcc gaggcagagg tgcagcgttc
4067881 agtggagcgc ttcaaggccg gtacacactg atttgggctt agggcgcccg ccccgcgcct
4067941 tggcaccctc cgccggtcat gatccgaact tcgtggggga cctgactgtt aggcgattgc
4068001 gccgcacact ctcggtgaac gccgccccga taaaaaccac ccccaccgaa gcggtgaccc
4068061 actcggggac ggcgaatcgg tggtcgatgg acaacagcaa gattatggcg agcgcgccaa
4068121 tcgcccagtg tgcgccgtgt tccaggtaca cgtaccggtc cagtgtgtcc tgtcgcacca
4068181 gatagatcgt gatcgaccgg acaaacatcg cacccaccac accaaggccg agcgcgatga
4068241 tgatcgggtc cgtagtgatc gcaaaggccc cggtgacgcc gtcgaaagag aaggcggcgt
4068301 cgagcacctc cagatacagg aacaacgcgc aaccagcctt tccggccgcc tgcctcgcct
4068361 gcacgcccgg cgtggcttca cccaaccccg ccggccggaa cgcccggctg atcccgttga
4068421 cgacaagata ggtcaccatg cccaaaaggc cggcgatcag caccgtaccc cgctgatcgc
4068481 tggagtgtgt caacagcgcg ccggcaagga ccaacccaac actggccact atcaccggga
4068541 cctgaccgag tcgaccgatg cgggcaaagg ggacctcaat ccacttcagc catttgatat
4068601 cgcggtcgtg aacgacgaag tccaggaaaa gcatcagcag gaacatgccg ccgaacgccg
4068661 cgatctgcgg atgcgcagcg gtgatcagtt tttcatagct gggcgatccg tccgcaaatt
4068721 ccagcgcgcc atgggccggt ggacgaagcg ccagctccat tgcgcggacg gggtccaggc
4068781 ccgcggtggt ccagatgatg gccagcggga acaccagccg catcccgaac accgcaataa
4068841 gaatcccgat ggtcaggaac atccgctgcc aaaacgggct catccgctgc agaatcgcgg
4068901 cgttgatgat ggcgttgtcg aacgacagcg atacctcaag gagcgccaga accgccagca
4068961 agaacagggc ggtcggcccg ccgtgcaaat atccggtaac caacgccacc accgtcatca
4069021 gcagcgagaa gccgaagatg cggaacgttg acatggatcc ttccgaggaa aaaccccaca
4069081 atagcgacga accgacatca attggtcagg ctcgcgccgc gcagcgcggc caaccggccc
4069141 gcctactatt ttcagtcgtg acgatccatg tcggttggcc gttggcgccg ccgcggtgac
4069201 cgaagtcggc gatacggcat ctcctgttgg ctcctcgggc gcctctggcg gagctatcgc
4069261 aagcggcagc gtagcccggg tcggcacggc ggccgcggtt accgcgctgt gcggctacgc
4069321 ggtgatttat ctggcggccc gcaacctggc tcccaacggc ttctcggtat tcggggtgtt
4069381 ctggggcgca ttcggactgg tcaccggggc cgccaacggc ctgctgcaag aaaccacccg
4069441 cgaggtccgc tcgctggggt acttggacgt ctctgcagac ggccgccgta cccatccgct
4069501 gcgggtctcc gggatggtcg gcctcggctc gttggtcgtg atcgccggta gctcaccgtt
4069561 gtggagcggg cgggtattcg ccgaggcgcg ctggctatcg gtcgcattgc tcagcatcgg
4069621 gctggctggg ttttgcctac acgccaccct gctgggcatg ctggccggca ccaaccggtg
4069681 gacccagtac ggcgcgctga tggtggccga cgcggtcatc cgggtggtgg tcgccgcggc
4069741 cacgttcgtg atcggatggc agctggtcgg gttcatctgg gcaaccgtgg cgggttcggt
4069801 tgcctggctg atcatgttga tgacctcacc cccgacacgc gcggccgccc gcttgatgac
4069861 gcccggcgct actgcgacat tcctgagggg cgccgcccat tcgatcatcg cggccggtgc
4069921 cagcgcgata ttggtgatgg ggtttccggt cttgctgaag ctaacctcca atgaactggg
4069981 cgcgcaggga ggcgttgtca tccttgcggt gacgttaacc cgggcgccac tgctggtgcc
4070041 actgaccgcc atgcaaggca acctcatcgc gcatttcgtc gatgaacgca ccgagcggat
4070101 tcgggcgcta atcgcgccgg cggcgctcat cggcggcgtt ggcgcagtcg ggatgctggc
4070161 ggccggcgtc gtaggtccat ggattatgcg cgtcgcgttc gggtcggaat accagtccag
4070221 cagcgcattg ctggcctggt tgacggcggc cgcggtggcg atcgcaatgc tgacactcac
4070281 cggtgccgcc gcggtcgcgg ccgcactgca ccgggcgtat tcgctgggct gggttggtgc
4070341 gacggttggg tcgggcttgt tgctgctgct gccgctgtcc ttggagaccc gcaccgtggt
4070401 cgcgttgtta tgcggtccgc tggtgggaat cggcgtccat ttggtggcgc tggcgcggac
4070461 ggacgagtaa gcggccgatc agccccggac caacgtgtaa cttgtgggct taaatggcct
4070521 cgaaaatgga cactgaaacg cactactcgg acgtctgggt cgtcattccc gccttcaacg
4070581 aagccgccgt gatcggcaag gtcgtcaccg atgtgcggtc agtcttcgac cacgtcgtct
4070641 gcgtggacga cggcagcacc gacggcaccg gcgacatcgc ccggcggtcc ggtgctcacc
4070701 tcgtacgcca tccgatcaac ctgggccagg gggcggccat tcagaccgga atcgagtacg
4070761 cccgcaagca gccgggcgcc caggtctttg ccacctttga cggcgacggc cagcaccgcg
4070821 tcaaagacgt ggccgcaatg gtcgaccggc tcggcgcagg tgacgtcgat gtggtgatcg
4070881 gaacgcggtt cggccggccc gtgggcaaag cttcggccag ccgaccgcca ctgatgaagc
4070941 ggatcgtgct gcagacagga gcgcggttga gccgtcgagg ccgccgactt ggcttgaccg
4071001 acaccaacaa tggcctgagg gtgttcaaca agaccgtggc cgacgggctg aacatcacca
4071061 tgagcggcat gagccacgcc accgagttca tcatgttgat cgccgaaaac cattggcggg
4071121 tagcggaaga accggtcgag gtgctctaca ccgagtattc gaagtcgaaa ggccaaccgc
4071181 tgctcaacgg cgtcaacatc attttcgacg ggtttctgcg agggaggatg ccacgatgaa
4071241 ctggatccag gtgctgttga tcgcgtcgat catcgggttg ctgttctacc tgttgcggtc
4071301 gcgccgaagc gcgcggtcgc gtgcctgggt caaggtgggc tatgtcttgt tcgtgctcgc
4071361 cggcatctat gccgtgctga gaccggacga caccacagtg gtcgcaaact ggtttggggt
4071421 gcgccgcggc accgacctga tgctctacgc actggtgatg gcgttcagtt tcaccacact
4071481 gagcacctac atgcggttca aggacctcga gttacgctac gcgcgcatcg cccgggctct
4071541 ggcacttgag ggcgcacagg cgcccgaaca gtgccggtaa gacccagcca cttgagggcg
4071601 cacaggcgcc cgaattaagc cgcgattcga tctgcgcaga ccgtagccag gaaggacccg
4071661 gcggcctaca gttcttagag ttactgcatc tctgaccagc aggaggcgat atgtccgacc
4071721 ctgacgacgt caccacatca tctgacgacc gcgacgaggg cgaaccggaa atagacctgc
4071781 tgccggcctg atgactcaga gctcatcggt cgaacgcctg gtcggcgaga tcgacgagtt
4071841 cggttacacc gtagtcgagg atgtcctcga cgccgattcg gttgccgcat acctagcgga
4071901 tacccgtcgg ctggaacggg agctaccgac cgtcatcgcc aactccacaa ccgtcgtcaa
4071961 gggcctggcg cggcccggcc atgtcccggt cgaccgggtc gaccacgact gggtgcgcat
4072021 cgacaacttg ttgctgcacg gcacccgcta cgaggcgctg ccggtacacc ccaagctgct
4072081 gccggtcatc gagggtgtgc ttggccgcga ctgcctgttg tcgtggtgta tgacgagcaa
4072141 ccagctgccg ggcgcggtgg ctcagcgctt gcactgcgac gacgaaatgt atccgctgcc
4072201 gcggccgcat caaccgctgc tgtgcaacgc gttgatcgcg ctgtgcgatt tcaccgccga
4072261 caacggcgcc acccaagtgg tgcccggttc acatcgctgg cccgagcggc cgtcgccgcc
4072321 atacccggag ggcaagccgg tcgagatcaa tgcgggcgac gcgttgatct ggaatggcag
4072381 cctgtggcat accgccgcag cgaaccgcac cgatgccccg cggccggcat tgaccatcaa
4072441 cttctgcgtg gggttcgtgc gccagcaggt caatcaacag ctgtccatcc cgcgagagtt
4072501 ggtgcgctgc tttgaacctc ggctacagga actgatcggc tacgggctat acgccggaaa
4072561 gatgggccga atcgactggc gaccgccggc cgactatctc gacgccgacc ggcatccgtt
4072621 cttggacgcc gtagcggacc gtctgcagac ttcggtcagg ctctgatcaa tcagtgtgct
4072681 tgtgccggaa gtactcgacc gtgcgacgca cgccgtcggc caactcgatc tgcggacgcc
4072741 agcccaaaac ccgttcggct aagccgatgt caaggcagga ccgcttaaga tcgcctagcc
4072801 gcggcgggtg gaactcaggg tcgtcgggcc cgccgacagc cgcggccacc gccgaatgca
4072861 gttggcggtc cgacgtttcc ttaccggtgc cgatgttgaa gcgcagccca ccgccgacgt
4072921 ccgcggacac ccggacaaac gcgtcgacca cgtcgtcgac aaacacatag tcgcgcgtat
4072981 tggtgccgtc gccgaacacc ctggtgggtt tgcccgagag cagcgcctgc gcgaagatcg
4073041 ctaccacacc cgcttcaccg tgtgggtcct ggcgaggacc gtagacgtta gccggtgcga
4073101 tatgcgagca gtccaggccg tagagatgtc gaaaggtgtt caggtagatt tcgccggcca
4073161 ctttgcccgc ggcatacggc gaggccggat cggtgggcgc tgtctcaggg gttggatact
4073221 ccggcggggt gccatagatc gatcctcccg aggaggtgtg cacgatcttg cggacaccgg
4073281 tctgccgcgc ggcctcggct aggcgcaccg tgccgatgac attgaccgcg gcgtcgaatt
4073341 gcgggtcagc caccgaacgg cggacatcga tctgggccgc caggtgaaat accacctcgg
4073401 gccggtgctg ctcgaggatg gcgtgtagat cggcggtcac aatgtcggct tcgacgaaga
4073461 cgtgtgcgga gttgtcggcc agatgctcga ggttggtcgc ccggccggtc gcgaagttgt
4073521 ccaatcccac caccgaatga ccatctgcca gcaaccggtc gactaacgtc gagccgatga
4073581 atccggccgc cccagtgacc agtgcgcgca ccggcccacc ataccggcgg cccatgccag
4073641 cgccccgtat gcctcgggtc gccctggtcg ccgtattgct gatcacggtg cagctggtgg
4073701 ttcgcgtggt gctggcattt gggggctatt tctattggga cgacttgatc ctcgtcggca
4073761 gggccggcac tgggggcctg ttgtcgccgt cgtacctgtt cgacgaccac gacggccacg
4073821 tgatgcccgg tgccttcctg gttgcgggcg ccattatccg ggtggcaccc ctggtgtgga
4073881 ccggaccagc gatcagcctg gtggtgctgc agctgctgga gtcgctggcg ttgctgcgcg
4073941 cgttgtatgt gatatcgagc tggcggccgg tactcctgat cccattgacg ttcgcgctgt
4074001 tcacaccgct agcggtgccg gggttcgcgt ggtgggcggc tgcgctcaac tcgctgccga
4074061 tgctggccgc gctggcgtgg gtgtgcgccg atgccatcct gctggtgcgg accggcaacc
4074121 accgctacgc cgtcaccggt gtcctggttt acctcggtgg cctgctgttc ttcgagaagg
4074181 ccgcggtgat cccgttcgtc tccttcgcgg tggccgcgct gcagtgccat gtgcgcggcg
4074241 accggtcagc tttggcgacg gtgtggcggg ccggtgtccg gttgtggacg ccgtcgctgg
4074301 cactgaccgt cggctgggta gccctttatc tggcggtggt ggatcaacgg cgatggagtt
4074361 ccgatctgtc gatgacgtgg gatctgctgt gccgttcggt cacccacggc atagtgccgg
4074421 cactggccgg cgggccgtgg gactgggcgc gctgggctcc ggcatccccg tgggccactc
4074481 ccccggcggt ggtgatggtg ctcggctggc tggtgttgat cgcagtgctt gcgctgtcac
4074541 tggtccgcaa gcgacgcatc ggcccggtgt ggctgaccgc ggccggctac gcggtggcct
4074601 gccaggtgcc gatctttctg atgcgctcgt cgccgttcac cgcgctcgag ttggcccaga
4074661 ccctccggta cttcccggat cttgtcgtcg tgctggcgct gctagccgcc gtcgcgctgc
4074721 aggcacccaa tcgcgccggc acccgctggc tggacgcctc gccggcccga gccgttgcga
4074781 cagtcgcttc ggccgtgttg tttttgacca gcagcctgta ttcgaccgcg acgtttctgg
4074841 ccagttggcg tgacaacccc accgagggat acctgaagaa cgcccaggca agtctggccg
4074901 cggccgcgtc aggtgcgccg ctactggatc aggaagtcga tccgctggtg ttgcaacgag
4074961 tggcctggcc ggagaacttg gccagccaca tgttcgccct gctgcgcgtc cgaccggaat
4075021 tcgctacgac aacaacacaa ttgagaatgt tcaccagcac aggtcggctg gtcgacgcga
4075081 aagtgacctg ggtccggacg atcatcgcgg ggccggtgcc gcagtgcggc tacttcgtcc
4075141 agccggaccg gccggaacgt ctgatcctcg acggcccctt gctgcccggc gactggaccg
4075201 tcgaactcaa ctacctggcc aacagcgacg gctcgatggc gctggcactt tctgacggac
4075261 ctgagcggaa ggttccggtg catccgggtc tcaatcgggt gtacgcccgg ctaccagggg
4075321 ccggcgacgc aatcacggtg cgagccaaca ccaccgcgct ttcgctgtgc atcggagcgg
4075381 cgccggtggg atttctggca ccggcctgac ctcaacgccg gtcgccacag ccgctcaaac
4075441 gtggcggccg cgcgtattcg accgtccgta gtggttcgtt aaagcgttgc agtacaacgc
4075501 atacaacaat caatcggcca ttgagttcgc acgctcatgc agttgcgaat ggtcggtgga
4075561 tgctcgaagc caatgcagaa agcgaccggc tcgatgagct gcaccagcag tatcaccgag
4075621 atgatcttgg cggtaatcag gcttgtatct cttgtagtgt ggcggcggca actgaatact
4075681 gaccagagcg cggcaactga aaattgacca gcttcctgga gagccttggc tatgggccaa
4075741 ggaggaagcg agtgttgagc gtggaggatt gggccgagat ccggcggttg cgccggtcgg
4075801 agcggttgcc gatttcggag atcgcgcggg tgttgaagat ttcgcggaac acggtgaagt
4075861 cggcgttggc ctccgatggg ccgccgaagt accagcgtgc ggcgaagggc tcggttgcag
4075921 atgaggccga gccgcggatc cgggagttgt tggcagccta tccgcggatg cctgcgacgg
4075981 tgatcgccga gcggatcggt tggtggtatt cgatccggac gctcagcggg cgagtacgcg
4076041 agttgcggcc gctgtatctg ccgccggatc cggcgtcgcg cgacatatgt ggccggtgag
4076101 atcgggcagt gcgacttctg gttccccgat gtcgttgtgc cggtggggta cggccaggtc
4076161 cgcaccgcca cggcgttacc tgtgctgacc atggtgtgtg ggtattcgcg gtgggcctcg
4076221 gcgctgttga tcccgacacg caccgccgaa gacttgtatg ccgggtggtg gcagcatctt
4076281 tcgacgttgg gcgccgttcc aagggtgttg gtgtgggacg gcgagggcgc ggtcgggcgg
4076341 tggtgggcgc gccaacctga actgactgcg gcatgccatg ccttccgcgg caccctggcc
4076401 gccaaagtgt ggatctgtaa accggtgatc ccgaagccaa ggggctggtc gaacgtttcc
4076461 acgactacct ggagcgggcg ttcttgccgg gtcgggtctt tgcctctccg gcggatttca
4076521 atacccagtt gcaggcctgg ctggtgcggg ccaatcaccg ccagcaccga gtgctgggat
4076581 gtcgaccggc agatcgcatc gaggccgata ccgcagcgat gctgacattg ccgccggtcg
4076641 ggcccagcat cgggtggcga acctcgacac ggctgccgcg cgatcattac gtgcgcctcg
4076701 acggcaacga ctactcggtg catccggtcg cgatcggccg gcgcatcgag atcaccgcag
4076761 atctgagccg ggtccgggtc tggtgtggcg gcaccctggt cgccgatcat gaccgcatct
4076821 gggccaaaca ccagacgatc agcgatcccg agcatgtcgt ggccgccaaa ctgctgcgac
4076881 gcaaacggtt cgacatcgtc ggtccacccc accacgttga ggtcgaacaa cgtctcctga
4076941 ccacctacga caccgtgttg ggccttgacg ggccggtggc ctgatggcag ccaagaccgc
4077001 taccaacagc cgcgatgtgg ccgccgagct ggcgtatctg acccgggcgc tgaaagcccc
4077061 caccctgcgc ggggccatcg agcagctcgc tgaccgcgcc cgcaccaaga cttggagcta
4077121 tgaggagttc ctcgcagcgt gtctgcaacg cgaggtgtcg gcccgcgaat cccacggcgg
4077181 cgaaggacgc atcagggccg cccgcttccc atcgcgcaag tcgttggagg agttcgactt
4077241 cgaccacgcc cgcggtctca aacgcgacac catagcgcat ctgggcaccc tggacttcgt
4077301 caccctagca atcgggatcg cgatccgcgc ctgccaggcc ggccaccgcg tcctattcgc
4077361 caccgcctcg caatgggttg atcgtctggc cgccgcccac cacagcggca ccctgcaatc
4077421 tgaactgatt cggctggccc gatacccgct gctggtcgtc gacgaagtgg gctacatccc
4077481 cttcgaaccc gaagccgcca acctgttctt ccaattggtg tcgtcccgct acgaacgggc
4077541 cagcctcatc gtcacgtcaa ataagccctt cgggcgctgg ggcgaagtat tcggcgacga
4077601 cgtcgtagcc gcggccatga tcgaccgact cgtgcaccac gccgaagtca tcgcactcaa
4077661 aggagacagc taccgcatca aagaccgaga cctcggccgc gtccccaccg tcacggccga
4077721 cgaccaatga aaccaagctg gtcaattttc gattgccgac acctgatcag ttttcggttg
4077781 ccgttgacat agtgcccaaa acacgcaccc acatcagatg cagaacccct tgacaaccaa
4077841 tagggaatct cttcgcatga tggaggttgc tggcaccaat ccatcaggaa ggcccttgtt
4077901 gaccggcact gggttggggg tccaccgcga tgggtgagta tggcaagtgc ggcacgtatg
4077961 cacccgtctt ggtgcacgcg gccaagggca gcccgttagc gccgtcgccc agcgtgaact
4078021 gagggcggag aatcggccgg aatctcgccc tcagtgcacg ctcggcgccg tttggcctca
4078081 cccggtcaac gtgaactgtc cggggcgggc actgtcgcgt agcgagccca cgtggggccg
4078141 gggtcggccc gccaaaaacg ccccggcgcg gccagctcat gagcgggtac gcaagctcaa
4078201 gcagatctcc gtagccgtga cggagtgctt catcgatgtc cgcagcgatg gcagcggcca
4078261 gtgcgtgcct aaacccgtct tgcgcagagt ctttcgcagc gggcgggtag ttgcacgtcg
4078321 tcgccgaagt gctgacgatc ccgttgcggt cggagaccgc gagtagccag cgcgcgtccg
4078381 gggcagcatc tcgcgcagca cgctgaagtg tcgcggcacc ggaagccggg ggcgtgaaga
4078441 gacccgccat gacaccggct ggacggcgcg gggcagagtc ccgcggagtg gtgggcttcg
4078501 acgttgagtt cgtcggtgcc tactggccgc cgctgattgc ggcgaccaca gcattatcgc
4078561 tatcggggta gagcagcgcc atagaggcct cggagaggta gcggcgctcg ctggcctgcc
4078621 attcgtcgtg catgtcggcc aggacggcgc ccacaaggcg gatcacggct gcaggattcg
4078681 ggaagatccc cacgacgcgg gagcgtcgct tgatctcctt attgatgcgc tccaatggat
4078741 tggtcgacca gatcttttgc cagtgcgcct tgggaaatgc ggtgaacgcc aatacttctg
4078801 ccctggcgtc gtccatcagc gggccgatct tgggaaacga cgcggcgagg cgatcacgga
4078861 ccccctccca ggtcgcgtgc accgcctcgg cgtcgggtgc cgagaaaatc attcgaaaca
4078921 tgctggcgac catgtcggcc ttgtccttgg gcacgtgggc gagcagattg cgcgcgaagt
4078981 gcacccgaca gcgctgatgc ccagcgccct ggaaacagcg cttcaacgcc ttcaccagcc
4079041 cggcgtgctg gtcactgatc accagccgga caccaccgag gccgcgcccc ttgagcgagg
4079101 tcaggaaccc gcgccagaag gtctcatcct cgctgtcgcc gacgtcgagg ccgaggatct
4079161 cgcgtgaccc gtcggcggcg atgccgctgg caacgatgac ggccatcgac accacctggc
4079221 cagtaccgtt gcgcacgttg agataggtgg cgtcgaggta gacgtagggg aactcgatgt
4079281 gcccgagcgt gcgggtgcgg aacgcgccga cgatctcgtc gagtccggca cagatccgcg
4079341 acacctcgga tttggagatg ccggtctcca cacccatcgc ctcgaccagg tcgtcgaccg
4079401 cacgggtaga gataccgtgc acgtaggcct ccatcaccac cgcgtacaag gcctgatcga
4079461 tccgccggcg cggctcgagg atcgccggga agaaagagcc cttgcgcagc ttagggattc
4079521 gcagttccac gtcaccggcc tgcgtggaca gcacccgcga tcgggcaccg ttgcgatcgg
4079581 tcacccgagt gtcgctgcgt tcataacggg cagcgccgat ccgttcagtg gcttcgagct
4079641 cgctgagttc ctgcaacacc agacggacgg catcacggat caagtcgacg ccatcaccag
4079701 tgcggaacgc gtcgagcaac tcggacaggg cagactgtgg caaggccatc ggcgggatct
4079761 ccttcggtgc gtgcttggcg gtacacaccg acgatctcgc cgacggcccc tacctcatcg
4079821 gagccactcc gcaacaaccc ctaaacccac cacgctgcgg gacgcttacc ggcggcgtgg
4079881 cacaacgttc ggtatcgctg atcggcatca ggaggttagt gcgatcagaa gtcgtaagtg
4079941 ggctcggcgt cgaggatccc cttgaacatc gcgaccaggc ccgtgagatc agagttggcg
4080001 cgcgccacgt gacaagcgcc gtgcaactct tccaggtcgg tcttccccca gtcgaggcca
4080061 gaaccgcgtt cggacaacag gagatcgaag aactcgcggg tcgagcggcc gttgccctcg
4080121 cggaacgggt gggcatagtt cacgtagtcg taccggtatg cgacctggcc agcgagatca
4080181 ccttcgccga ccgctctgag ccggtcgagc tggtagatct ccgcagccac atgctccatg
4080241 ggccgactga tgccgcccgg cgcgcagaaa gactcgtcct ccttctcgat gccgactgtc
4080301 cgcagatctc ccgcccagac gtaaatgtcc tggaacagct ggcggtgaat cgcccgcagg
4080361 tatgcgagat ctgtgcggtc gcccagcaga ttgggatcct cgcggagttc gatcacccgg
4080421 gcctcaacga ggtcgttctc ggcatcacgc agttcggcat gcgttcgagc gccgacccgg
4080481 ttcctcaaga cggacatagc ggggatgaag tagccctgcc aattccgttc gtgatcgccg
4080541 gtgtcccatg gatgcggcac tccaccccgg ttactggatg ttgtaccggc ggcggacgcg
4080601 ctcacccaac tcggctgccg tgatcttgcc gcgggcgtag tcgttctgat cggcacgggt
4080661 ggcggcggtg ctgcgggtgc cctccagctc ggtgttgcgg cgagttgccc tgacattcct
4080721 gaagcgccgc ttcaccttct gcaactcggt cgcctggaca aacacttcat ctcatttggt
4080781 ggtcctgacc aggatagtcg acagcgctga cattgcagga agttgaccgt caagcacagc
4080841 acggttctcc accgctgatg tacgaccatc atgtctcgtt ggtcctgtaa tcgacggcgt
4080901 cccaccggct cgacaagaaa tcccaccagg tgactggacg caaggccggt ggggccccct
4080961 acaccgtcac catcccggag ttcggagccg cagctttgcg cgagcagcgg gcactggtca
4081021 tcccgttcga cccggtgttt ccggcccggc gcggcacccg ctagtccgag gccaacgtcg
4081081 cacccactgg cgggcgatcc gcggagagga cttcaaatgg gttgtcccgc actcgatccg
4081141 caagtccgtc gtcaccgcgg tggaacgctc gatagggctg gaagccgcgg cccagcaggc
4081201 cgggcacagc ggcagcgaga tcacccggcg gcactacgtc gagcggtccg tgacggtgcc
4081261 cgactacacc gccgccctgg acgagtattc gcgccctatc cgcgccttca ggccattaaa
4081321 gagcaacagg ccgggtgata taccgacctg acctgcaaag atggagccgc ctaggagaat
4081381 cgaactcctg acctattcat tacgagtgaa tcgctctacc gactgagcta aggcggcttt
4081441 tcccctgggt gcccgcttgc cgggcggcac gagtctacgg caggcgggcc ggcccgccca
4081501 agtttgcggc ggtcgctacc gcagttcctg gccgatggtg gcgaccatgg catcgacggc
4081561 gaacttcggt ttgacgttga ccgctagcgc ttccctgcac gccaacaccg cttcgatgca
4081621 gcgcagcagc cgctccggcg gggcgtgggc ggccagcgca gcaacccggt cggccatatc
4081681 cgggtggttg gcccgcaccc cacccgcgtg ggctgcgacc aacagtgcat cccggaagta
4081741 ggtcgccaga tcgatcagtg cccggtccag cgcatcgcgc gaggcccgcg tctgccggga
4081801 tttctgccgt cgttcaagat ccttcatcgc gccggtggca ccacgcaacg ccgcgccggt
4081861 gcctttaccg gtacctccgg ctcccagcgc cgtccgcagt tcttcggtct cggcctcgat
4081921 acgctgcgcg gtcaacgcta aggcctcggc ctcggcgccg gccaccaact cctcggcggc
4081981 tgcgtaggca cgcgagggtg tcgcggcgtc acgtgccagc cccaaagccc gctcgcgtcg
4082041 ctgccgggcc tgcggatcgg tggccagccg gcgcgctcgt ccgacatggc caccactgac
4082101 cgacgccgcc caattggccg tgtcggggtc caacccgtcg ccgtcgctca gcacctgcgc
4082161 gatcgcgtgg gtcgacggag tcaccaacgc gacatgccta caccgggatc gcagcgtgac
4082221 cgcaatgtcc tcgggatcca ccgacggcgc gcacagcagg aacaccgtcg acggcggcgg
4082281 ctcctcgaca accttgagca acgcgttggc ggcgccttcg gtcaaccgat cggcgtcctc
4082341 aatcaccacg atctgccagt gcccggtagt cggccggcgc gcggcgattt gcacgatggc
4082401 ccgcatttcg tccacaccga tcgacagacc ttcgggaatc acccggcgta cgtcggcgtg
4082461 ggtgcccgcc agcgtggtcg tacacgcccg gcagcgcccg cacccgggct ccccgcccga
4082521 cgtacattgc aaagccgccg cgaagcacag cgcggcaacc gagcgcccag aaccgggcgg
4082581 accggtgagc agccacgcgt gtgtcatagt cccgccgcca cccgcgctgt gagccgaatc
4082641 acgacgggcc gccttggccg tggcaagcag ctcggcttcc accgcttgct ggcctaccag
4082701 ccgcgtaaac accccggaca tcatcggcaa cagtagctat ccgcgccgac agataccgat
4082761 cagcgttcgt ttcgcgacaa ttccgtgatc tttcgtcgcc atttggatgg atgccgaggc
4082821 gttcgtcggt ttccggcaag tccccgccgc ccgatacggt gggctaatgg caaccacggc
4082881 ggcgctaccc agacggatcc atgcattcgt ccggtgggta gtgcgcactc cgtggccgct
4082941 gttctcgctg agcatgctgc agtccgacat catcggcgca ttgttcgtgc tcggattcct
4083001 gcgctacggc ctgccgcctc aggacaatat ccaactgcag gatctgccac cggtcaacct
4083061 actgatcttc gtcagcacgg taatcatctt gttcctcgcc ggggccgtgg tgaacctgaa
4083121 gctgctgatg ccggtctttc gatggcagcg ccgcgacaac ctgctcaccg agcctgatcc
4083181 ggccgccacc gagctggccc gcagccgcgc attgcgcatg ccgttgtacc gcactctgat
4083241 cagcctggcg gtctgggcta ccggcggcgg ggtgttcatc ctcgccagct ggtcggtggc
4083301 caagcatgcg gcccccgtcg tggcggtggc caccgcgctg ggtgccaccg ccaccgccat
4083361 catcggctac ctgcagtctg aacgggtgtt acggccggtg gccgtcgcgg cgctgcgcag
4083421 cggtgtgccg gaaaacgtca acgcacccgg cgtcatactg cgactgatgc tggcgtggat
4083481 tccgtccacc ggcgtaccac tcctggcgat cgtgctggcc gtagcggcgg acaagattgc
4083541 cttgctgcac gccacaccag aggcgctgtt caatcccatc ctgatgatgg cactggccgc
4083601 gctgggcatc ggatccgtca gcaccctgtt ggtggccatg tcgatcgccg acccgttacg
4083661 ccagttgcgc tgggcgctaa gcgaggtgca gcgcggcaac tacaacgccc acatgcagat
4083721 ttacgacgcc agcgaactgg gcctgctaca agccggcttc aacgacatgg tccgcgagct
4083781 gtccgagcgg cagcggttgc gtgacttgtt cggtcgctac gtcggcgaag acgtggcccg
4083841 gcgggccctg gagcgcggca ccgagttggg cggtcaggaa cgcgacgtcg cggtgctgtt
4083901 cgtggatctg gtcggctcca cgcaactggc cgcgacacga ccgcccgccg aggtggtcca
4083961 gctgctcaac gagttcttcc gggtggtggt cgaaaccgtc gcccggcacg gtgggttcgt
4084021 caacaagttc caaggcgacg ccgcgctggc catcttcggt gcacccatcg aacaccccga
4084081 cggtgctggt gccgcgctat cggcagcacg tgagctccac gacgaactca tcccagtgct
4084141 gggttccgcg gagttcggca tcggcgtgtc ggccggaagg gccatcgccg gccacatcgg
4084201 cgctcaagcc cgcttcgagt acaccgtcat cggcgacccg gtcaacgagg ccgcccggct
4084261 caccgaactg gccaaactcg aggatggcca cgttctggcg tcggcgatcg cggtcagtgg
4084321 cgccctggac gccgaagcat tgtgttggga tgttggcgag gtggttgagc tccgcggacg
4084381 tgctgcaccc acccaactag ccaggccaat gaatctggct gcacccgaag aggtttccag
4084441 cgaagtacgc ggctagtcgc gcttggctgc cttcttcgcc ggcaccttcc gggcagcttt
4084501 cctggctggc cgttttgccg gaccccgggc tcggcgatcg gccaacagct cggcggcgcg
4084561 ctcgtcggtt atggaagcca cgtcgtcgcc cttacgcagg ctggcattgg tctcaccgtc
4084621 ggtgacgtac ggcccgaatc ggccgtcctt gatgaccatt ggcttgcccg acgccggatc
4084681 tgttcccagc tcgcgcagcg gcggagccga agcgctttgc cggccacgac gtttcggctc
4084741 tgcgtagatc ttcagggctt cgtcgagcgt gatggtgaat atctggtctt cggtgaccag
4084801 tgatcgagaa tcgttgccgc gctttagata cggtccgtag cgcccgttct gcgcggtgat
4084861 ctcctcaccc gaggcggggt ccactccgac cacgcgcggc agtgacagca gcctcagcgc
4084921 gtcttcgagg gtgaccgtct gtaggtccat gctccgcagc aacgaaccgg tgcgcggttt
4084981 gggcccggcg gccttctggc gtttcttgac tccctgagcg gccgcggccg catcagccgc
4085041 aggctccggc aggatctcgg tcacatacgg cccaaaccgg ccttccctgg ccacgatctc
4085101 gtggccggtt tctgggtcca agcccaaagt ccgtccctgt tgcggtgtgg caaagagctc
4085161 ttcggccacc tgtagagtca gctcgtccgg ggtaatcgag tcgctgaggt tggcccgctg
4085221 cggcgtgggc tcaccggtgt cgccggccac caaacgttcc aggtagggac cgttcttgcc
4085281 cacccgaaca tatatggggc gtccgtgggt gtcgtcaaaa agcttgatag agtttacttc
4085341 tcgtgcgtcg atgccctcga gattgatccc gacaagcttc ttgaggccac ccgatcgggc
4085401 taccgaatcg ggcacaccgt gatcgccacc aaagtagaag ttgttgagcc agttggtgcg
4085461 gcgctcgttg ccggcggcga tctcgtcgag ctcgtcttcc atcgccgcgg tgaagtcgta
4085521 gtcgacgagc cgaccgaaat gctgctcgag cagaccggtt accgcgaacg ccacccatga
4085581 cggcaccagt gcactgccct tcttgtgcac gtagccgcga tcctggatgg tcttgatgat
4085641 cgacgagtag gtcgacgggc ggccgatgcc cagctcctcg agcgctttga ccagcgacgc
4085701 ctcggtgtag cgggccggcg ggttggtggc atggccgtct ggggtcaact cgacgatgtc
4085761 caaccgttga cccggggtca gatggggcag tcgccgctcg gcatcgtcag cctcgccgcc
4085821 gaccagctcg tccacggtct ccacgtaggc cttgaggaag cccgggaacg tcaaggtgcg
4085881 tccggtcgcg gagaacacca cctcctggtg ccccgacatg ccagtgatcc gcaggctcag
4085941 cgtcatgccc cgcgcatcgg ccatctgcga ggctacggtg cgttgccaaa tcagctcata
4086001 gagccggaaa tcatcaatgt tgggaccgtc gagttcgcga cgcaccgcgt ccggggtggc
4086061 aaacgtttca ccggcgggcc ggatagcctc gtgcgcttcc tgggcgttct tcaccttgcg
4086121 ggtgtattgg cgcggcgccg gcgcgacgta ctcgtcgccg tagagctggc gcgcctgggt
4086181 acgtgcggcg ttgatcgccg actccgacag cgtggtggag tcggtacgca tataggtgat
4086241 gtagccgttt tcgtacagcc gctgggcgat gctcatcgtc cgctcggcgg agaaccgcag
4086301 cttgcggctg gcctcttgct gcagcgtgga ggtcatgaac ggcgggtacg ggcgccgggc
4086361 gtagggcttc tcctcggccg aggccacggt cagctgcgtg ccatccaggc ccgcggccaa
4086421 cgcggtcgcg ctcccctcgt cgagcacaat gacttcgtcg cctttgcgca gcgtgcccag
4086481 cgagtcgaaa tcgcggccag tggccacccg ccggccagcc acggccgtca gccgggcgct
4086541 gaaggtgggc ggcgcggcgt ccgggtcgga cacgctggca tccagcttgg caaggatgtc
4086601 ccagtaggcc gcgctgcgga acgccatgcg gtcgcgttcg cgcgccacga tgatgcgggt
4086661 ggccaccgac tgcacccggc ccgccgacaa cttgggggcg accttcttcc acagcactgg
4086721 gctgacttcg tagccgtaca gccggtccag gatgcgccgg gtctcctgcg cgtcgaccag
4086781 gtcgatgtct aggtcgcggg ggtgctcggc ggcggcgcgg atcgccggtt cggtgatctc
4086841 gtggaagacc atccgcttta ccggtatgcg cggtttgagg gtttccagca gatgccaggc
4086901 aatagcttcg ccctcacggt ccccatccgt ggccagatac agctcgtcca cgtctttgag
4086961 caggcccctg agctcgctga cggtgctccg tttctccggg ctgatgatgt agagcggttc
4087021 gaagtcggcg tcgacgttga ccccgagccg cgcccacggc tgcgacttgt actttgcggg
4087081 tacatccgac gcggcccgcg gcaagtcacg gatgtgcccc cgggaggact cgacgatgta
4087141 gccagagccc aggtaggagg ccagcttgcg cgccttggtg ggcgactcga cgatgaccag
4087201 tcgccggccg ctgccattgc cgccgctgcc acggcccttc gttttcgggt cagccaactg
4087261 cgcccacgct ccatctctta tcccggcccc tatcgagacc gccccggtag gtagaggacg
4087321 cggccgactg ccgaatccca ggtgaattcc ggtacgccgg cgttccctcg cctgtgggca
4087381 actgacaatc tcgcactcta gggcgggcct gcgcaaaccg gctgcaaaca gattacccac
4087441 accaaaggct caaacgggcc gctcaggacg ctcggagatc cgcatcgtcg ccgaactagg
4087501 tccgactgcc cggctcctca gcggacccca gcgggaccgc atcgtcgccg agctaggtcc
4087561 gactgcccgg ctcctcagcg gaccccagcg ggaccgcatc gtcgccgagc taggtccgag
4087621 gccactgtac ccatgcctcg gccccgtctg ggggttcccc cacgttctcc accaggcgcg
4087681 ataacctgcg tcgcccgcta atccgcagcg ctggtcgggt cccccgggta ccgatcaggg
4087741 tgggcgcaat cccgaccctc atcagcgccg acgccagcgg agaatgggtg tccggcgcgt
4087801 gtggatccag gcccagcaaa tagcggtcgg cctccgggct gcctgccgcc agagtccaag
4087861 ccctcagctc gcgcggcccg ggcagccatc gcgggggcac ggtcttgacc gcaccgcgcg
4087921 tccactcggc ggcgatgccg cacaacagcg ggtcgacggc cgtccgcacc agcggggtgt
4087981 tttcgtcggt acgggcgacc tcgggtacca aaccagcctc ctggatcatc tcggccaggg
4088041 ccgatgcgcg ccaggactcg gcgacgacta ccgacagccg agcgccgcaa ccaaccagca
4088101 cgatctggcc cgggcccgcc agcaccccgg aaagatccgc gaccgcggga ggtactgact
4088161 ccgcggcgaa gaaggaaagc tggctcacct caccgacagt aagccagcga gcgggtcgct
4088221 ggctttaggc atccggcgcg gcggcagcgc gccatgtggc gagcagacgt aaagccccca
4088281 aaacggaacc gttttggggg ctttttgcgt ctgctcgcgg gggtaactca gagcgagcgg
4088341 actccggtgg cctgggggcc cttagggctg tggccgatct cgaactcgac cttctggttt
4088401 tcttcaaggg tgcggaagcc cgttccctgg atctccgtgt agtggacaaa tacatccgcg
4088461 gaaccgtctt cgggggcgat aaagccgaac cccttctccg cgttgaacca cttcacagtt
4088521 ccctgtggca tttctcgatc tttccttttc ttctgggtgc ggtgcaccgc ctttcggtgc
4088581 cccgggccag ctgcggccgc catacctcgc cgagtcgccg gaacttcacc cgaccgataa
4088641 cctcgcagga accgcggccg caacgtcgat cctgcgaaag tttgacacga acacagaagc
4088701 tgcgaccgcc aatcagtcaa tcatgttcat cgcgtcggca acagcctctg ggtgtggacg
4088761 gagctacgaa gggtccgcaa atggcgagtt tcggcagcca cctgctggcc gcagcggtcg
4088821 ccgggacccc gccgggcgag cgtccgctgc gccacgtcgc cgagctgcca ccgcaggccg
4088881 gccggccgcg cggttggccg gagtgggccg agcccgacgt ggtggatgcg tttgccgacc
4088941 gcggcatcag ctcgccgtgg tcacaccagg ctgaggccgc cgagttggcg tacgccggcc
4089001 gccacgtggt gataggcacc ggcccggcgt ctggaaagtc gttggcctat caacttctcg
4089061 tgctcaacgc gctggcaacc gactcccggg cgcgtgcgct gtatctgtcg ccgacgaagg
4089121 cgctcggcca cgaccagttg cgcgccgcac atgcgctggc ggccgcggtg ccacggctgg
4089181 ctgacgtcgc gccgacggcc tatgacggcg acagtcccga cgaggtgcgc cgctttgccc
4089241 gcgagcgctc ccggtggctg ttctccaacc cggagatgac acacctatcg gtgcttcgaa
4089301 accatgcgcg ctgggctgtg ctgttgcgga atctccgctt tgtgatcgtc gacgaatgcc
4089361 attactaccg tggtgttttc ggctcgaatg tggcgatggt actgcgccgt ttactacggc
4089421 tgtgcgcgcg ctactctgcg cacccgacgg tgatcttcgc cagcgcgaca acggcctcgc
4089481 cgggcgcgac ggctgccgac ctgatcggcc agccggtcgt ggaggtcacc gaggacggct
4089541 caccccgggg ggctcgcacg gtggcattgt gggagcccgc gctgcggtcg gatgtgatcg
4089601 gcgagcacgg cgccccggtg cgacgctccg ccggtgccga ggcggcccgg gtgatggccg
4089661 acctgatcgt cgagggagcg cagaccttga cgttcgtccg atcgcggcgc gcggcggaac
4089721 tgactgcact gggtgcccgg gcgcgactgg tcgacattgc cccggaactg tcggacacgg
4089781 tggcgtcgta tcgggccggt tatcttgccg aggaccgtag cgcgctgcac caggccctgg
4089841 ccgagggcca gctgcgcggg ctggctacca ccaacgcttt ggagttgggc gttgatatcg
4089901 ccggactgga tgcggtggtg ctggctggtt ttcccgggac ggtggcctcg ttctggcagc
4089961 aggcgggccg gtcgggccgg cgcggccagg gcgcgctggt ggtgttgatt gcccgtgacg
4090021 atccgctgga cacgtatttg gtccaccatc ccgcagcatt gttggacaaa ccggtcgagc
4090081 gcgtggtgat cgatccggtt aacccgcacc tgctgggtcc ccaattgctt tgtgcagcaa
4090141 cagaactgcc tttagacgac gccgaggtcc ggtcctgggg cgccgttgag gtggcggaga
4090201 gtctggttga cgacgggctg ttgcggcgcc ggaacggcag gtactttccg gcgcccgggg
4090261 tgaaaccgca tgccgccgtg gatgtccggg gggctatcgg tggccagatc gtcatcgtgg
4090321 aggccggaac cgggcggctc ttgggcagcg tgggcgtcgg tcaggccccg gccgcagcgc
4090381 acccaggcgc ggtgtacctg caccagggcg agacctacgt cgttgactcg ctggatttcc
4090441 aggacggaat cgccttcgtg cacgccgagg atcccggcta tgccacgttc gcgcgagagg
4090501 tcaccgacat cgcggtcacc ggcaccggcg agcggttggt cttcgggccc gttgctttgg
4090561 gtttggtgcc ggtgactgtc accaatcacg tcgtcggcta cctgcgccgc cagctgtccg
4090621 gggaggtgct ggacttcgtg gagctggaca tgccggaaca caccttgccc acaaccgcgg
4090681 tcatgtacac aatcacttcg gatgcattgg tccgcagcgg tattgaggcc acacggattc
4090741 ccgggtcgtt gcacgccgcc gaacacgcgg ccatcgggct gctgccgctg gtggccagct
4090801 gcgaccgcgg cgatatcggc ggcatgtcca cagcgaccgg gcccgagggg ctgcccagtg
4090861 tctttgtcta cgacggctat ccgggtggag ccggattcgc cgaacgcggc tttcgccggg
4090921 cccgcacctg gctgggcgcc accgcggagg ccatcgaagc ctgcgaatgc cccagtgggt
4090981 gtccatcgtg tgtgcaatcc cccaagtgcg gcaatggcaa cgacccgtta gacaaggcgg
4091041 gcgcggtgcg ggtgctgcgg ctggtgctcg ccgagttaag tgaggaatca ccgtgagcag
4091101 cccagcgttc cggcgttgtc gggcaaagcg gggtcgtcgt cttagccgat gtgatgcact
4091161 tgacatcagt gtcttcggcc tatcacgtag tggtcgtggg cgccggccga agatccgggc
4091221 gggaggtgac acgtgtcgtt tgtgatcgcg gcgccggagg cgttggactc ggcagcaacg
4091281 gacctcgtgg tcctgggctc gacgttaggc gcggccactg cggccgcggc ggcccagacg
4091341 acgggtatcg tggccgcggc ccacgacgag gtgtcggcgg cgatcgcagc cctgttttcc
4091401 gcccacggcc aggcctatca ggccgccagc gcgcaggccg cggcgtttca cacccggttc
4091461 atccgtgcgc gctcccgaca tccgcagcag gaaacgacct gtcgccgtgt gcgataggca
4091521 aatcaccagg caacacgccg gcagctccgg taaggccaac atcgaccacc tacccagggc
4091581 attcccatgc acgtcaccgc cgcatagcaa gttgcggatg ctgagtggtc cgctaccacc
4091641 cggtatggca acgccggtgg tcatggcacc acctcgggtc tgatctgcct cggaggccgg
4091701 ccgctggcac gaaggcaacg acggttcggg cgggttggcc tagcgatacc acacgcatgc
4091761 gctgtcctgc aagggaattc cctcggcgac caccggtacc ccaccgagtc aacggcgcac
4091821 cgcgtccgta gactgctcgc atgacccacg actggctgct cgtggagacg ctgggggacg
4091881 aaccggccgt ggtagcacgg gggcgtgagc tgaagaagct cgtcccgatc accacgttcc
4091941 tgcgtcgcag tccctatttg gcggcggtcc gcacagctat cgccgagacg ctgcagaccg
4092001 gccaaagcct gaccagcatc actcccaagc acgatcgcgt catccgcacc gaacctgtaa
4092061 taatgaccga cggccgcatg cacggcgtgc aggtgtggag tggccccaca gacgccgaac
4092121 cgcccgaccg gccgatccca ggcccgctga agtgggacct gacccgtggt gtggccaccg
4092181 acaccccgga gtcactgacc aacagcggca agaatcccga ggtcgagatc acctacggcc
4092241 gagccttcgc cgaagacctg ccggcgcgcg agctcaatcc gaacgaaacc caggtgcttg
4092301 ccatggcagt taaagccaag cccggcaaaa cactatgcag catttgggat ctcactgatt
4092361 ggcaaggaac acccatccgg atcggcttcg tggcgcgaag cgctctggag ccgggaccaa
4092421 acggccgcga tcacctggtc gcccgggcaa tgaattggcg tgctgagacc aaggcccctg
4092481 cagtgcccgt cgacgacttg gctcagcgga tccttatcgg actggcgcag gccggagtcc
4092541 accgggcact ggtcgatctc aaaacctgga ccctgctgaa atggctcgac caaccctgct
4092601 ctttctacga ctggcggcgt agcgcggccg atgggcctcg tctacatccc gacgaccagc
4092661 acgtgatcga cgccatgaca agagacctcg ccaacggatc ggccagtcat gtgctgcgct
4092721 tgcctgggca cgacgtcgat tgggtgccgg tccatgtcac cgtcaaccgg atagagctcg
4092781 aaccggatac cttcgctgga ctggtcgctc tgcgactgcc caccgacgaa gaacttgccg
4092841 acgccggact gccgaaagcc accgacgtca ccacctgaca accagtcctt tcgactcagc
4092901 aacggcagct gccgatccgc ggctaccgtt gcttgtcgtg aacggtttga cggtgatccg
4092961 gactgcgcgc tcgctgagcg gcctacgccc acgctgtcgg tcagattgcg tcgatgaatc
4093021 ctatgcgctc tgaactgaac tgggctgaat gcgcgagccg ccgacgtagg gaatcggcaa
4093081 cgcccgtcgg acgaccccgc cgatctcgtc gtcgacatcc agtggcgccg gcatcagcag
4093141 ggtggtgacg attgcccgtt cagacagtcg ccgcaaggcc ccgggcctgc taggaggtcg
4093201 ggttccccgg gacgtcgacc acaccctggt cgcaatgtcc aacgtaagca acaggtttga
4093261 gtatgaggtg ccggtagcga ggatgaattc gccagtcctg gtacacgcgc acggacatcg
4093321 caggtgccgc gatgcggccg gcctctggcc accgccgaat cggcgtagcc gtcgggcact
4093381 ttcaagatcg ggtcagcgcg cctgatgcgc accgggccgc cacctcagcg ccatggtgtt
4093441 tcggacatcc tccaatcgcc gccgatcccc gaggaacacc aggtcgcccg cgtgcgggcg
4093501 aaaggcagcg aggacttttg ggaaacccac gcacatgctt cccggatagc gataagctgc
4093561 gctccagcag attgtccgcc ggtgaccggg cggcccttcg atcggcatcg cgcggtggtc
4093621 ggaggtgtcc gatgtcatat gtgatcgcgg cgccggaggc gctggtggcg gcggccacgg
4093681 atttggctac tctcggctcg acgatcggcg ccgccaacgc ggccgctgcg ggctcgacaa
4093741 cggcgttgct gaccgccggc gccgacgaag tgtcggcggc gatagcggcc tattcggaat
4093801 gcacggccag acctatcagg cactcagtgc gcgggcggcg gcgttccatg agcggttcgt
4093861 gcaggccttg gccacaggtg ggggcgccta tgcggccgcc gaggccgcca gcgtctcgcc
4093921 gctgcagagc gcgctcgatt tgctgaatgc gcccactcag gcgctgttgg ggcgtccgtt
4093981 ggtgggcaat ggcgccaatg gggccccggg gactggggca aacggcggcg atggcgggat
4094041 tttgttcggg tccggggggg ccggcgggtc cggagcggcc ggcatggcgg gtggcaacgg
4094101 cggggccgcc gggctgttcg gcaacggcgg agccggcgga gccggcggca gcgcgacggc
4094161 cggtgcggcc ggggcgggcg ggaacggcgg ggccggcggg ctgctgttcg gtaccgccgg
4094221 ggccggcggc aacggcgggt taagcctcgg tttgggcgtc gccggcggcg ccggcggcgc
4094281 cggcgggtcg ggcggtagtg acaccgccgg acacgggggg accggtggtg ccggcggcct
4094341 gctattcggc gccggcgagg acggcacaac gcccggtggc aacggtgggg cgggcggtgt
4094401 cgccgggctg ttcggcgacg gcggcaacgg tggtaacgcc ggagttggca cgcccgcggg
4094461 caacgtcggc gccggcggca ccggcggcct gctgctcggc caggacggca tgaccgggtt
4094521 gacgtagccg cgtggcgggg ccgcgccttg cttccgggac taccacccgc aggtcgctgg
4094581 ccgtagttgg ttctccccgc tagcccacca ctagcttcgc ttgccgatag cttcgcttgc
4094641 cgatagaact agatcgtcgt caacccggtg tcgtgggcac cttggccggc cccgcccgcg
4094701 cggtggcggt cgccacaccc gcgaacgcga cagccacctc gacggtgacg accacgtcga
4094761 ggtccaccac cctgcactgc gcgtgctcga cgcgcatcgc acgggccacc agcgtcgcac
4094821 gcgcgcaggc cgccgccagt ccggacggca gccgggcggc agcggctaac gaagccagat
4094881 cagccgccgc ctgtgcgcgg tgacgagcca ccaccgccga ccctagatat gcacccgcac
4094941 cggtgacgca cagcagcacc gcgaccatcg cgacggcaag cacggtggcc gagccgcggt
4095001 cgaccccggc tcggccaccg aaattgccct agcagcaatg tccaacgtag gcaacaggtt
4095061 tgagtgtgct gtgacagtgg cgaccacaaa ctcgccgtcc cggtgcacct ggaccagcgc
4095121 cgcacgcggg gcgatgctgc gggcgacgtc ggtcgccgag cgtacgtcac cgcgcgcggc
4095181 caatcgagcg gcctcgcggg ccgcgtcgat acagcgcacc tgcattgata ccgcggtgac
4095241 gcccgccagg cacagcacca gcaccagcac cagggtggcg atcgccaacg ccgcttccac
4095301 ggtgctcgca cccgcacacg acgctaaacc ttggtgctga gcgcgcgacc gatgatgcgg
4095361 ttgagcgccg acacaatgga atccccggtg acgaccgtgt agaggatcgc accgaaggca
4095421 gccgccgcga tggtaccgat ggcgtattcc acggtggaca tgcccgactc gtcgaccgcc
4095481 agcgccgtca tccgcgccac gagtacacga aacatggtga tcaccaacat attcctttct
4095541 cataccaggc caaactgcaa gacatcaccg gccagcccga ctactagcgg gacaatgccc
4095601 acacacagaa acgccggtaa gaagcacagt cccagcgggc cggcgatcag cacaccggcc
4095661 cgctcggcgg ccgccgcggc cgcctgtgcg gcgtcgtgcc gaacctggac ggccagttcg
4095721 acaatgccat cggcgagcgc cgcgcccgaa gccgccgaac gccgtgccaa ccgcagtacc
4095781 gcatcggtct gcgcatcgtg ggtgcccggc ggcaaatccg gcggcctcga ccaggcgatg
4095841 ttggggtcgg cacccaatgc cagcaggtcg gcggcccggc gcaacacgcg cgccagccgc
4095901 ggcggcgcga ccgcagcggt ggcggccgcg gccgtcgaca ccgccatccc cgcagccaga
4095961 cacacggcca gcacgtcaag gctggctgcg acggctagcg ggtccgcgac atccgtccgc
4096021 cctagcagca gcccctggtg tggccgatgc gcgcggggcg gcctcccggc tcgcgcccgt
4096081 accaccgacg ggccggcacc gagccacaac gccatggcca gcaacaccgc cgccgcactc
4096141 acaacactgg ccgatcggtg atccggtccg accacagcag cccggcgcag gccagtgtca
4096201 gcccgaccac cagcagccat ccgcccacgc gtcccgtcag cagaaagctc agcggccggg
4096261 cgccgatcag ttgaccaagc agcaccccga gcagcggcag gattgccaat atggccgcac
4096321 tggcccgggc accggccatc cccgctgaca cccgcgcgga gaaccgttgc cgctcagcga
4096381 catcacgttg ggcggcacgc atcaaactgg ctatcgccaa gccgtgatca ctgcccagtt
4096441 gccagcagac cgcgagccgc tcccagtacg cgggcagcgc cgaggatcgg gccgcagcga
4096501 gcaggccagc cgtgacgtcg gcacccaatc gtgcccgcgc cgcgaccgcg cgcaaggcaa
4096561 cggcaaccgg gccgccggtc tcgtcggccg cgatgctgaa tgcgcggact ggatgggcgc
4096621 ccgcgcgcag ttcacccacc accagctcaa gcgcggcctc cagcgcctgc ccctcgcggc
4096681 tgcggcgcag gtagcggcga cgccggcggt agcgcaggcc gagtgttgcg cccagcaccg
4096741 cgacagccac aacggtcggt aacggtagca aggctgccac accaaccgcg acacagccaa
4096801 caccccaggc aacccgccgg gcgccgacca gaagcacccg ccggccggtg tcgtctggag
4096861 taaggcggca ccgcggcgac ccgggcaaca ccacgagcgc aagcgacaaa atcagggcag
4096921 cggacgctat accgctcatg ccgatgcccg gcttctcagc aaatcgtgca gggcggccgc
4096981 gtcgtcactc atcccacggt ccgcgtgcca caccgtcacc gcctggaccc gcccttcagc
4097041 ttggcgcagc acggcgatct cggcgagccg gcgacggcct gcccgatcgc gcgcgacgtg
4097101 cagcaggact tggactgccg cggcgagctg gctgtgcaga gcagcgcggt caaggccgcc
4097161 gagcgccccc aacgcttcca tgcgtgcagg gacctcaccc gggttgttgg cgtgtacggt
4097221 gcccgcgccg ccctcgtgac cggtattgag cgccgccaac agatccacca cctcggctcc
4097281 cctaacctca ccgaccacga tgcggtcggg ccgcatccgc agcgcctgtc ggacgagttg
4097341 acgcacggtt acctcaccga ttccttcgac gttcgcacgc cgcgcaacca gcttgaccag
4097401 atgtggatgc cgaggggcca gctcggcggc atcctcgacg cacacgatcc gctcatcggg
4097461 cgacacggcg cccaacatcg ctgccagcaa cgttgtcttc ccggcaccgg ttccgccgca
4097521 cacgaggaat gccagccggg cggtgacgat gtcggcgacc agcgcggcgg ccgcggggtc
4097581 gatcgcgccc gccgcagcca acgcggccag atcctgagtc gcgggacgca acacccgcaa
4097641 cgacaagcaa gtgccctggg tcgccacggg cggcaacacc gcatgcagcc gcaccgcgaa
4097701 ccctccgacg ccgatcccgg ttagttgacc gtccacccag ggttgcgcgt cgtcgagccg
4097761 acggccggcc gccaaagcca gccgttgtgc caaccttcgc accgctgact cgtcagcaaa
4097821 ccgaatctgg ctgcgtcgca atccgtttcc gtcgtccacc cacaccgagt cgggcgcggt
4097881 gaccagaacg tcggtggtgc cgtctgcgga tagcagcggt tcgaggatgc cagcgccggt
4097941 cagttctgtc tgcagcacac gaagattcgc cagcacttcg gtgtcgccga gcatcccccc
4098001 ggactcggcc cggatcgcgg cggccaccac actgggccgc agcgggccgg attcggatgc
4098061 cagccgttcg cggacgcgtt cgatcaggga gccggtcatg ccgccctacc gtgtcgccct
4098121 gacccagcac gtggcagcac accaagtacc cgtcgggcag ccgatgccag caccgatcgc
4098181 cgtcgcagtc gaagaccccc gtgttccagc tgttcggcta gccgcggctg ggccctcatg
4098241 gatgccagta gcggcacccc ggcgacgtcc gcgacctctg ccgcccgcaa tccccccggg
4098301 gagggccccc gcaccaccag acccaggttg gggttgatcg cggtcagcac aggcgccatc
4098361 gtcgcggcgg ccgcacatgc ccgcacatcg catgggctga ccaggacgac gagatcggcg
4098421 gcatccagcg ctgcttgggt ggcatcggtc agacgacgtg gaagatcgca gaccacggtg
4098481 actcccccac gtcggccggc gtcgatcacg gcgtccaccg gcccggcgtc taactcgtag
4098541 ccgcgccgag ttcccgagag cacgctgatc ccccgcggtc gcggcaatgc cgcacgcacc
4098601 gccgaccaat tcagccgtcc accctgtagc gccaggtcgg gccaacgcag accgggggcg
4098661 gtttcgccgc ccaccagaag atcgatgccg ccggcccacg gatcgagatc gaccaacagc
4098721 gcatcagcgg cggcctgcgc cagggcaacc gcaaacaacg atgccccagc gccaccgcga
4098781 cccccgatga ccgcgaccac cgccccgcag atcccgtcat cgcgtgccga ttcagcagct
4098841 tcggcgagct cgcggaccag ttcaccctcc tgctcgggca tcctcagcac gtgctgggcc
4098901 ccgacggtta tggcagccgc ccaggtcgcc gtcgcggctt cggttccggt caacacgctg
4098961 acgtgggtgc gccggggtag cgcgagccgc ccacaccggt ccgccgccgc gtggtcgagc
4099021 accacagccg ccgccgccga ccacgtcttt ctgctcaccg gatggcggcc gccgagatga
4099081 acaacgcgaa ccccgacggc tgcggcgact cggtccagct cgtcgcgcaa ccccggatcg
4099141 gtcagcatcg ccaacacgcc cgagcccacc gggtggctac cagacgggcc accagggcct
4099201 gagaagactg tcacccaccc accgtgcggg gtccatggtg tgggacacca gtcccaaagg
4099261 cgcaattggg gacagacgtg caactgtgca caaacgcccc tgagggggtc cgggcaacac
4099321 gattcccgca acgcccagaa agctgggcta agcaccgggc tgacgacgtt tgcgtggctg
4099381 ccaaaaggga cgacccccgc caggggggga ggaggcgagg gtcgtcgtgc atcagccccg
4099441 gggggtcgga ctgatacacc ctcggctatg gccgagtaat gcttactata cacatgacag
4099501 tgcgcagtca cgcaagtacc ggacgcaatg gaaagcacag cttgagccgt gtaaatgctc
4099561 ttgacttctc gacaacatcg gtagtcaatt gacctgttcg ggaacaaggt cgccggccgg
4099621 tccaactgcc gacctatgct gggtcggtga ccgtctccga ctcgcccgcc cagcggcaaa
4099681 ccccaccgca aacaccggga ggcaccgctc cgcgagcccg caccgcggcc tttttcgacc
4099741 tggacaagac catcattgcc aagtccagca cactggcgtt cagcaaacct ttcttcgctc
4099801 agggactgct caaccgccgc gccgtgctga agtccagcta cgcgcagttc atctttctgc
4099861 tgtccggtgc tgaccatgac cagatggacc ggatgcgcac ccacctgacc aacatgtgcg
4099921 ccggttggga cgtagcccag gtgcggtcga tagtcaacga aaccctgcac gacatcgtga
4099981 ccccactggt gttcgccgag gccgcggacc tcatcgccgc ccacaagctg tgcggccgcg
4100041 acgtcgtggt ggtctcggct tcgggcgagg agatcgtcgg cccgatcgcc cgcgcgctgg
4100101 gcgcgaccca tgcgatggcg acccggatga tcgtcgagga cggcaagtac acaggcgagg
4100161 tcgcgttcta ctgctacggc gaaggtaagg cgcaagccat ccgtgagctg gctgccagtg
4100221 agggctaccc gctggaacac tgctacgcgt actccgactc gatcaccgat ctgccgatgc
4100281 ttgaggcggt tgggcatgcc tcggtggtca accctgatcg cggcttacga aaggaagcca
4100341 gcgtgcgcgg ttggcccgtg ttgtcgttct ctcggccggt gtcgctgcgc gaccggatcc
4100401 cggcaccgtc agccgcggcg atcgccacga ctgcggcggt gggtatcagc gccctagccg
4100461 ccggcgcggt cacctacgcg ctactacgcc gcttcgcgtt tcagccctag cgacgatgcg
4100521 ggccacacag tggcccgagg aggaacgggg ccacgaagca ggccgccgga tcgcgcccga
4100581 gcgggcgggc agcaaacgtc tagcccacgc aatccaaagc cgcttcgtaa ctttcgcaga
4100641 attgggcctt gctgtgttaa aggtctagta gtacaaagga accacggaag cccggtgagg
4100701 ccaaggctcg atccagaaga gaaggttcgg tctcccgacc cgggcgccca gcatggttcc
4100761 cggcacccac gcggagtcat agccacgata acggcagaag tgttgcgggt ctgcgtaatt
4100821 gcgaacagca gatggcatcg acggcccttt gggtggggct acagctagaa gcgtcgcaag
4100881 atcgccgagg ccacccacgc aaccccagga gtgcacgctt ggtaaccgag aaccgtgttg
4100941 gtgggcggcg attcgagttc ttcgggtcgc cgcctgcttt ttgttttctg gatcaagtat
4101001 tacggccatt cgaggcccgc cggttagccg ctcggctatc taggcgcgta attcagtgac
4101061 cgtttggccg ggctgtctcg cggctgtgcc agatcacagc ggcgaagtgc cgcagccgtg
4101121 acccgctcgg ggtagccggg ctgtttgagc aaccagacac gccgaacgtg caaccacggc
4101181 ggctccaccc ggcggggcgt gtccccgcca ccaatgcacg ttcggcgcag ccggcgcacc
4101241 ctcggcgcgg agtttaggaa ctactcatcc aggtgacaac gactcggcaa tcgacaaagc
4101301 ctcccgcgcg ccgtcgagca tcgcgccgca acacagcaac agccagcccg ccaccccatc
4101361 aggtgtgccc ccggcgaacc tgcgggcagc gtcgtggtat tcggcgggtt ggcgcatcca
4101421 aatcacttcg ggaacaccca gcccgtgcgg atccagtccg gtggcgattg tcaccagccg
4101481 cgacaccgcg cgggccacca caccgtcggc acagccaaac ggcctcagcg tcaagagctc
4101541 cccgtgtgcg accgcagcaa ccaccggcgc cgatgccagg gtggggtggg ttaccacatc
4101601 cgcgagcaac tccaaacgcg ggccaacgtc ggcatcggac cgcggacgcc caagccgatc
4101661 gtcatcgacc tggtcggcgg ccgccagcat gtgtaggcgg gccagcgcct gcaacggtgc
4101721 ccgccgccac accccgacca ccggacccgc gccgccttcc agcgcctgcc ccacccgaag
4101781 cgctcccgcg aacaccggat cgctgagcgc cggcttgccc gaggtgggcg cccccgcgtc
4101841 gtgcagccgc gcaggaccac cgtcgagcac cgaggaggcc cgcgccgccc gcaacgaggc
4101901 ctcggcggcg gccaccggcc agccccgcag gttggcccgg tgccggtgca cgcggctcag
4101961 cgcgtcgcgc acccggtcgc tggccgcagc aacgcccggg agctccatta gcggagccag
4102021 cgggtcgacc gtcacaggtt gccaaccttt cggggagctg agggggcacc gggaatggcc
4102081 tgaagcaact ggcgggtgta ctcgtggcgg ggccggctga acacctcctc ggtagaggcg
4102141 tgctccacca cccggccggc ccgcatgacc aggacgtcgt cggcaatctg ccggatcacc
4102201 gccagatcat ggctgatgaa caaatacgtc aaacccaggt cggcctgcag atcggccagc
4102261 agatccagga tctgtgcctg caccaatacg tcgagcgccg acaccgcttc gtcgcacacc
4102321 aatacctccg ggcgcagcgc cagcgcacgc gcgatcgcta cccgctgccg ctgaccaccc
4102381 gacagctcac ggggccgccg gcccagtatc gacgacggca gcgccacctg atcgaccagc
4102441 tcacgcaccg ccctttgccg ctgccggcgg tcaccgacgt gatggacgcg taacggttcc
4102501 tcgatggcgc gaaacaccga gtacatggga tccaggctgc tgtatgggtt ttggaacacc
4102561 ggctggaccc ggcggcgaaa ggccagcacc tggtcccggg ccagcgcgcc gacgtcgtag
4102621 gtgccgtcga aaacgaccgt gcccgaggta ggttggagca gcccaagcac catccgcgct
4102681 agcgtcgact tgcctgaccc ggattcgccg acgattgcca gggtgctcgc ccgcggtagc
4102741 cggaatgaca ctccgtcgac ggcgcgagac tccacccgcc gccacggtgc gccgcgggac
4102801 tcccggtaaa tcttggtcag ctccgagacg acgagaatgt cgccggcctg cgtggttgcc
4102861 cgtgaccggg attccggcgg acgtctgctg cgcgccgtca gcgatggagc cgcggccacc
4102921 aggcgccggg tgtactcgtg ctgagggctt tgcaggattg actgcgccgc accggattcc
4102981 accaccactc cacgacggac gacgacgaca gcctcggccc gctgcgcggc caacgccaga
4103041 tcgtgggtga tcagtagcag cgcggtgcct agttcgtcgg tgagtccctg aagatgatcg
4103101 agcacctgcc gctgcacggt gacatccaac gcggacgtcg gctcatcggc gatcagcagc
4103161 cgcggcctgc ccgccaagcc gatcgcaatc aacgcccgct ggcacatgcc gccggacagc
4103221 tgatgcgggt agcgtccggc ttgcttcgcc ggatccggca ggcccgcctc agcgagtagc
4103281 tccaccgccc gtcgtcgtgc tgcgcgaccg tcggtattgg cccgcaacgc ttctgtgacc
4103341 tgaaagccga ccttccaaac cggattgagg ttggtcatcg gatcctgggg aacatagccg
4103401 atctcccgtc cccttatcga ccgtagccgc ttggcatcgg ccccggtgat gtcgcgcccg
4103461 tcgaacacaa cgcgtccagc ggtgatccgt ccaccagccg gaagcaaccc aagaatcgcc
4103521 gcggccgtcg tggatttgcc cgacccggac tcacccacca cggcgacggt ttgaccgctc
4103581 cggacggcca gatccacccc acacacggcg ggagcatcgg tgccgaacgt aacttccagg
4103641 ccctccaccg acaacagcgg cgctgctggg acgctcatgc ccgccatgcc cgcgaagccg
4103701 gatccagcgc gtcgcgcaaa gcgtcgccca tcatcatgaa cgccagcacc gtaatcgcca
4103761 gcgcgcccgc aggatagaac aaaattggcg agcccgaccg tagccgggtc tgcgcgacat
4103821 tgatgtcgcc accccaggac accaccgacg tcggcaatcc gaccccgagg taggacagcg
4103881 tggcctcggt gacgatgaag atccccagag cgacggtagc caccgcgatc accgggccca
4103941 cggcgttggg cagcgcgtgc cgaagcagaa tctgaaacct attcaacccc aatgccttag
4104001 ctgcaaggac gtaatcgctg gcacgcacct cgagcaccgc accgcgcgcg atcctggcca
4104061 cttgcggcca gccgaacaat gccaagatgg cgatcaccgt ccacaccgtg cggtgatgca
4104121 tgacttgcat gagcacgatg gcggccaaca gcaacggcaa gccgagaaac acatcggtga
4104181 cccgcgaaac caccgcatcg atccagctcc cgtaaaaacc ggccaatgcg cctaacgccc
4104241 cgcccacgac gaacacggcc agcgttgccc ccaacccgac cgtgaccgaa gcccgcgcac
4104301 catacaccgt gcgcgaatag atgtcgtggc cctgcaggtc ggtgccgaac cagtgcgcgg
4104361 ccgatggcgc aagcatgctt tggctgggat cggcataggt gggatcggct gcggtaaaca
4104421 acgacggaaa cgccgccacg acaagaatca gcaggatcag cgccgcggcg atcacgaatt
4104481 taggacgccg gcgcaacccg cgccaggcat cgagccagaa ccccgtgtgc tcagccatag
4104541 cggatccgcg ggtccagggc cgcatacagc agatccacca acagattggt gatcaggtag
4104601 atcagcacca gcaccgtcac gatcgacacc accgtcggcg tctcctgacg cgtgaccgct
4104661 tgatacagca cgcccccgac gccgtggatg ttgaagattc cttcggtcac aatcgctccg
4104721 cccatcagcg cgcccagatc cgcgcccagg aaggtcacca ccggaatcag cgaattgcgc
4104781 agaatgtgca ccgtcaccac ccggggccgc gacaacccct tggcggtggc ggtgcggaca
4104841 tagtcagcgt gtgcgttggc cgccaccgcc gagcgggtca atcgcaccac gtaggcgaat
4104901 gacatggcgc ccagcacgat cccgggtagc agcaggcggc cgacgctcgc ccgttcgccc
4104961 accgtgaccg gcgcgatttc gagctggacc ccgaataaga actgcgccag aaagcccagc
4105021 acgaagatgg ggatcgcaat aatgacaagt ccggtaacca gcaccgcgga atcgaagatt
4105081 ccaccctgac gtaggccggc gatcacgccg aatccgattc cgagcactgc ctccaccgcc
4105141 agggcgatca aggccagcct gatggtgacc ggaaacgcat gcgccagaac ggcactgacc
4105201 ggcagcccag aatacgcacg acccaagtca ccgtgcagaa ttccgcccag atagcgcaag
4105261 tattgcacga ggaacggatc gtcgaggtgg taatgcgaac gcagctgcgc ggccaccgcg
4105321 ggagtcaacg gacggtcgcc cgccagcgcg gcaactgggt caccgggcag cagaaagacc
4105381 atgccgtaga tcagcagtgt cgcgcccagg aaaaccggca ccatcacggc gactcggcgc
4105441 gcaacatacc agcccatgtc aggccttgac gatgttctcg tagtcgggca gaccattcca
4105501 ggtgacggtg acgttgctga cttgcgacga ccatccgacg acactgatgt aatcccagag
4105561 cggcacaact ggcatgtcgt gaaacaggat tcgctgcgcg tcgttgacca gctcgtggga
4105621 ttcggttaac gtgggggcgg cttcggcggc ggccagcgcc gcgtcgaatt ccgggttgat
4105681 gtagccgacg tcgttggatc cggcgccggc ggtgaacagc ggagcgagaa actcgatcat
4105741 cgacgggtag tcgccccgcc atccagcgcg aaatgcactg tcgatggcgc ggttggtgat
4105801 ctgggtgcga aatccggcga aggtgggctg cggcgcggcc accgcatcga tgcccaacac
4105861 gttcttgatg ctgttggcca ccgcgtccac ccaatcccga tggccagcgt cagcgttata
4105921 ggcgatcgcg taccggccgc tccacggtga gatcgcatcg gcctgcgccc agagccgccg
4105981 agcccgctgc gggtcgtagt ccagcacctc gttgcccggc aggttgggat cgaagcccgg
4106041 caacgaccgg gcggtgaaat cgcgggccgg actgcgggtt ccggcgaaga tctgctggca
4106101 gatttgcggc cggttgatgg cggccgacag cgccaaccgg cgcagccgcc cctcctcgcc
4106161 accgaaatgc ggcagccgca acggagtgtc gagggtctga ttgatcgctg cgggcccgct
4106221 ggtagcgtgg tcgcccaggt cgcgctggta gaccgtcaac gcgctcggcg gaatcgtgtc
4106281 caggacatcg agattgccgg acagcaagtc ggcataggcg gtgtccagat tggcgtagaa
4106341 ctcgaatcgc aaacctttgt tacggggctt gcggttgccg tggtagtcgg ggttgggcac
4106401 caggtcgatt ctgacgttgt gttcccaggc cggcccggct gggccgtcgg cgagtttgta
4106461 cgggccgttg ccgatcgggt tgcggccgaa cgcggccatg tcccgaaatg cggagtccgg
4106521 cagcggataa aacgagctgt ggccaaggcg caacgtgaag tcgatggtcg gcgccttaag
4106581 ccgcacggtg aactccaggt cgttgaccac gcgcaacccg gacatggtgg tccggctctt
4106641 atcccctggc gcgccggcca cgtcatcgaa cccttcgatc gggctgaaaa agtgctgctg
4106701 cagttgggca ttggtgctca gggctccgta gttccacgcg tcgacgaacg agtgggccgt
4106761 caccggcgag ccgtcggtga acttccagcc gggtttgaca gtgatccggt agttgacgtt
4106821 atcggcgctc tcgattgact gcgcgacctc cagcgacggc ttgccaacgg cgtcatagga
4106881 catcaggccg gcgaacaacc gatcgatgat gcgcccaccg ttgctgtcgt tggtgccggt
4106941 cgggatcagc gggttgggcg gttccccgcc gttgaccagc accacgtcag ggctcaggac
4107001 accgccgcca caaccggcca ctggcgcaag caccagcaat ccggtggcaa gggctgccag
4107061 ggccgcccgc atctgacgca ccatgacagc gaccctaaag ccttcttgtg cagtccggct
4107121 ccccagccgg tgaagtgcgg cctggccagc gcagccgaca cactcgccgg tgaccgttag
4107181 ctaccacgcc acccagagtg ccggcgaacc ggtgggacga tgttttggga acgctcacac
4107241 cgtcgttcgc gatccggtgt tggctaccca ccgcgactgc gcttcccaag ggaagacctc
4107301 gcccgaccgg gcgctgttgg cgtgcggcat cctcgaggag gaccggtggt gtcggcgctg
4107361 tggcgaggaa ggcagcccgc gcgacaccgt gaccaggagg ttgactcact ggtgtgggct
4107421 gcacccgggt gtgagcgtag atcactcatg tcttagccga tgctgccgct tggattgccg
4107481 ccgtcgtggc ccagcggtgc cccaacgcga tccgccgcgc cgataaagct aaccggtgcc
4107541 aacgaacgac gccacatcgc acatgtcgct cacgccagcc gatctccgtt gccggccacc
4107601 gtaaccgtca gcacgactcg gcacaatgcc agccgcacgc tgcaaggccg accaacgtgt
4107661 gatgtgtagc ctgcaagaca ccggctttct tggctatgac tgcatcctgg tcagcgattg
4107721 cactgtgacg actttgccca gctcaacctc tgccatgccg gctgtatcgt cgcgcggtta
4107781 ggctcacatc cgtgagtgag tccacccccg aagtctcctc gtcatacccg ccgccagcgc
4107841 acttcgccga gcacgcgaac gcccgcgccg agctttaccg cgaggccgag gaagaccggc
4107901 tggctttttg ggccaagcag gccaaccgac tgtcctggac gacgccgttc accgaggtgt
4107961 tggactggtc gggggcgccg ttcgccaagt ggttcgtggg cggcgagctc aacgtcgcct
4108021 acaactgtgt ggatcgtcac gtcgaggccg gccatggaga tcgggtcgcc atccactggg
4108081 aaggcgagcc ggtcggcgac cggcgcacgc tgacctattc cgatctgctt gccgaggtat
4108141 ccaaagccgc gaacgcgctc accgacctcg gtctggtggc cggtgaccgc gtcgccatct
4108201 acctgccgtt gatccctgag gccgtgatcg ccatgctggc ctgtgcccgg ctaggcatca
4108261 tgcatagcgt tgttttcggc gggttcaccg ctgcggcctt gcaggcccgg atcgtcgacg
4108321 cccaagccaa gctgctgatc accgcggacg ggcagtttcg gcgcggcaag ccatcgcccc
4108381 tcaaggcggc cgctgacgag gcccttgcag cgatccccga ctgctcggtc gagcacgttc
4108441 tggtggtgcg gcgcacggga attgagatgg cctggagcga gggccgcgac ctgtggtggc
4108501 accatgtcgt cggctcagct tcaccggcac acaccccgga gcctttcgat tccgagcacc
4108561 cgctgttcct gctgtacacg tcaggcacca ccggcaagcc caaaggcatt atgcacacca
4108621 gcggcggcta tctcactcag tgttgctaca cgatgcgcac cattttcgat gtcaagccgg
4108681 acagcgacgt gttctggtgc accgccgaca tcggctgggt caccggccac acctacggcg
4108741 tctacggccc gctgtgcaac ggagtcaccg aggttctcta cgagggcacg ccggataccc
4108801 ccgaccgaca ccggcatttc cagatcatcg aaaaatacgg cgtgacaatc tattacaccg
4108861 cccccaccct catccggatg tttatgaagt ggggccgtga gatccccgac agccacgacc
4108921 tgtccagcct gcggctgctg gggtcggtcg gcgaaccgat caaccccgag gcttggcgtt
4108981 ggtaccgcga tgtcatcggc ggcggacgca ccccgctggt agacacctgg tggcagaccg
4109041 agaccggctc cgcgatgatc tccccgctgc ccggaatcgc tgcggccaaa ccgggttcag
4109101 cgatgacgcc gctgcccggg atctcggcca agatcgtcga cgatcacggt gatccgttgc
4109161 caccgcacac cgagggcgcc cagcatgtta ccgggtacct cgtcctagac cagccgtggc
4109221 cgtcgatgtt gcgcggcatc tggggcgacc ccgcgcggta ttggcactct tactggtcca
4109281 aattttccga caagggctac tacttcgccg gggacggcgc tcgcatagac cccgacggcg
4109341 cgatctgggt actaggccgc atcgacgacg tgatgaacgt gtccgggcac cggatctcga
4109401 ccgccgaggt ggaatcggcg ctggtcgctc actctggcgt ggccgaggcg gcggtggtcg
4109461 gggttaccga cgagaccacg acccaggcca tctgtgcgtt cgtcgtgcta cgcgccaact
4109521 acgcccccca tgaccgcaca gccgaagagt tgcgcaccga agtggctcga gtgatctcgc
4109581 ccatcgcacg gccacgcgac gtccacgtag tgcccgaact acccaagact cgtagcggca
4109641 aaatcatgcg tcgactgctg cgcgacgtcg cggaaaaccg tgagcttggc gacacgtcga
4109701 cgctgctcga tcccaccgta ttcgacgcga tccgggccgc caagtaggtc gcggcacgat
4109761 caaccgggtc agcccagcca actcaggccg gtaccgggac gaatcccgcg cccggccggt
4109821 tcttggcgtt gatgtcggcc aggtcggcgt tgatcgacat caccaccgcc ggggtgtgca
4109881 gcgggatgta tttggtgatg caactcggca gattgtcgct gaatgcgccg tggatcatcc
4109941 cgaccagcag attgtcgacg gtcaccggcg caccggagtc gcccggtccg ccgcagacct
4110001 gcatcacaag ggtgcccgga ctctcccctg gcccccaggt aaccccgcac gagttaccgg
4110061 tggtgcggcc ctgcttgcag gcgatctggc cgaacgacgg gtccgggcca atgccgttga
4110121 tcgcaaaccc gttgaagacg gccaccgggg tcaccttggc cgggtcgaac ttgatcaccg
4110181 cgtagtccag gccgtcgttg ccggcgacca tgatgcctac cgggcccgcg ttctcggcac
4110241 cctcagcggc gatctgcgcg cccgggcccc cacagtgggc ggaagtgaag ccgatgaggt
4110301 caccgttctt gtcatggccg atggtggtta gggtgcacat ggtgtccccg ttgacgacga
4110361 tgcccgcacc accgcccagc ggtagcttgt cgtcggctgc cgcggtgttc gcaggtaggc
4110421 acacaacggc caaaagcacg gccgcgaatg ccgcggcaaa gcgcctgtgc gccgtctgca
4110481 acgcaatgct cccgtcatat cgtcagacac ttgagaacag atccgccagt ttagacgatc
4110541 gcaccgcaac atcggcctct gttcaaacgg ccgcacacgt caagacgtgg ctaactctgt
4110601 cccgccgccc ttggtgttgg ctggcctcgt atggcaccgc accgcatggc aacatgaacc
4110661 gcgatgccag ccgaaccgct cggcgacgat gcgggccgga tgacggcccg aggaggagcc
4110721 gagcaatcga accgagctcg gcgacgatgc gggccggatg acggcctagg gtggggtacc
4110781 gccgctggcg agggcgagcc gagcaatcga atcgagagga ccgtctgtga gcaagatcga
4110841 tcgcaagaac ggtgtgccca gcacgctgac cacgattccg ttggccgacc cgcacgccgg
4110901 acctgctgag ccgtcgatcg gtgacctgat caaagacgcg acaacgcaga tgtcgacgct
4110961 ggtccgagcc gaggtcgagc tggcccgcgc cgagatcacc cgggacgtca agaagggact
4111021 gaccggcagt gttttcttca tctcctcgct ggtggtcggg ttctactcca ccttcttttt
4111081 cttctttttc gtcgccgaac tgctcgatac ctggatctgg cgctgggtgg ctttcttgct
4111141 cgtgttcgcc ataatggtcg tggtcaccgc cgtgttggcc ctcttgggtt tcctgaaagt
4111201 ccggcgcatc cggggaccgc ggcagaccat tgcgtcggtc aaagagacgc gcaccgcact
4111261 taccccgggc catgacaaaa cccctgtgac accaaaaccc gtgacatctg atcgcgcgac
4111321 gccggttgac ccctcgggtt ggtagatggc ggcaccagat ccgtcgatga cccgcatcgc
4111381 cgggccatgg cgtcatctgg acgtgcacgc caacggcatc cgattccacg tcgtcgaggc
4111441 tgtgccgtcc ggccagccgg agggcccgga tgcggctacg ccccccatgc agccggccct
4111501 ggcgaggccg ctggtcatac tgctccatgg tttcggctcg ttctggtggt cctggcgtca
4111561 tcagttgtgc ggcctgaccg gggcgcgggt ggtcgcggtc gatctgcgcg gctacggcgg
4111621 cagcgacaaa ccgccccgcg ggtacgacgg ctggacgctg gccggcgata cggccggtct
4111681 catccgtgcg ctcgggcacc catcggcgac gctggtcggc cacgccgatg gcggactggc
4111741 ctgctggacc accgcgctgc tgcattcgcg gctggtgcgc gccatagcgc tgatcagctc
4111801 accgcacccc gccgcgctac ggcgatccac gctgacccgg cgtgatcagc ggcacgcact
4111861 gttaccgaca ttgctgcgtt accagctgcc gatctggccg gagcgcttgc tgacccgcaa
4111921 caacgcagcg gagatcgagc gcctcgtgcg cgcccgtggc tgcgccaaat ggcttgcatc
4111981 cgaggacttc tcgcaagcaa tcgaccacct tcgacaggcg atccagatcc cggcggcggc
4112041 gcattgcgca ctcgagtacc agcgctgggc ggtgcgcagc cagctgcgca gcgaagggcg
4112101 gcgattcatc agggcgatga cacagcaact ggggatgccg ctgctgcact tacgaggcga
4112161 cgccgaccct tacgtgctgg ccgacccggt agagcgcacc cagcgctacg caccacacgg
4112221 gcggtacata tccattgccg gcgcaggaca tttcagtcac gaagaggcgc cggaggaagt
4112281 caaccgacat ctgatgcgtt tcctcgagca ggtgcaccag ctcagctgac gcaggccccg
4112341 gtgccgaccg gttgggtagc accgattttg gcaagctgcc ccgccacctc gccggccgtc
4112401 agcacaaacc cagtttcggc gtcgtcgatg gctgcgccga acaccacacc gagcacctga
4112461 ccgttgaggt cgatcagggg cccacccgaa tcaccttgct ccacatcggc tctgatggtg
4112521 tacacgtcgc gggtaaccgg ctccgggtcc ccgtaaatat cggggccact gagtctgatg
4112581 gcctcgcgaa tcctggcggg tgtggcagtg aaattgccgc cgccgggata acccagcacc
4112641 acaacgtcgg caccggtttt cgccggctcc gcagcgaaga ccagcggcgg cggcggcaag
4112701 tgcggaacgg ccaggatcgc tacgtcgacc gacgggtcgt aggacaccac cgtggcctcg
4112761 aagggcttgt cgccggcata caccgtgacg ttgttggatc cggccaccac gtgcgcgttg
4112821 gtcatcaccc gatcgggtga gatcacgaag ccggtgccct ccaacacttt ctggcatctg
4112881 ggtgccaggc tgcggatttt gacgacactt ggctcggtgg ccgccaccac cggattgttg
4112941 accagcgctg ggtcgggtga ggccactgga atgaccggcg tgcggctgaa cggctccaaa
4113001 accgcgggca ggccggaggt gttcagcagg gccgacagcc gcttgggcac cgtcttcagc
4113061 caggtgggtg ccgcctcgtt gacccgggcg agcacccgcg aacccttcac cgcggcagcc
4113121 agctcgggct gctctttcga ctgtgtcagc ggcatcgcca acaaccacgc cgcggtgagc
4113181 accacgacca gctgcacccc taccccaatg accgagtcga tcaaccggat cggccggtta
4113241 cggatcgccc cgcggacggc gcggcccagc accacaccag cgacctcgcc gactacgacc
4113301 agtgccagga tcaggaacag cgcggcaaac agtttggccc gcggagcgct gatttgactg
4113361 acgatatgcg gcgccagcag cacgccggct gtcgcgccca gcagcacccc gccaaacgac
4113421 agcattgagc ccagcgcacc ggcacgccag ccggagatgg ctgcaataaa tgcgaccgcc
4113481 aagacggcga tatccagcca ctgcgacggg gtcatcgaat tcatcgcggg tcactctcgt
4113541 cgtcgatcag caccattgcc gcgtccaact cgcggatgtc accggtgtcc cagggttgtg
4113601 cccagcccgc gacatcgagc accgcggaaa tcacctggcc agtgaagccc cataccagca
4113661 tctggtttaa caggaacgcc ggcccggccc agcgacgagt gtgcgggcgg cggtacacca
4113721 tgagccgatt ggccggattg atgaaggcgc gcaccggtac ccgcgcgacg atcgccgttt
4113781 cggcctcgtt gacgacggcc accggcccgg gatccggcga gtacgccagc accgggacaa
4113841 catggaaccg cgacggcgca atgaacgtcc gctccatggt ggccagcgga tgcagcctgg
4113901 acgggtcaat cccggtttct tcgttcgcct cacgcaaggc ggtggccacc ggcccgtcgt
4113961 cggcggggtc gaccacaccg ccgggaaaag ccgcctggcc ggcatggtgg cgcaatgtcg
4114021 aggcccgcac ggtcagcagt aggtcggcgt cgtctgggac accaccgtcg cctggcccgg
4114081 cctccgggcc agaaaacagc accagaacgg ccgcctcgcg gtgatcccgg cgcgacgatg
4114141 tcattgccga cacagccccg gcggccgtca ccatcgctag cacatcggcg ggcaaccgac
4114201 gccggtaggc gtcgggtatc tggccaacgt tgtcgaccag tggacgcagc caggacgggc
4114261 cggcatcagg ccgcagggca accgtccccc gtgaaccggt gggggtcgct cccgcttgca
4114321 ggggggtacc cccagcactc atcggcgcct cctttgggtc caaagttgcc cagctcctct
4114381 tcaagccgct aacccggccc acatcaccgc cgagtggagc ccacctgctc agagcaggcc
4114441 ggaccggcta cgcggcccgc accgcaaccg tactcatccc gcgtcgttcc cgaccgcagc
4114501 cacgatctcg tcggcactgc cgaaagcccg cggcagggtc tgggcaacgc taccgtccgg
4114561 ccgcagaacc accgtcgcgg gcatcacatt tgcgacccgc agcgcggccg ccaccctgcg
4114621 gcggtcatcc tgcagcgtcg gcaaccggac gccgagatcg gccagccgcg acagcgcggc
4114681 cgcctcgttc tggccctgat gcaccgtcac gaccagcacg gcgggcccga cccgtcgttg
4114741 atattcggcc atcacgggca gctcggtcat gcacggcgcg caccaatgcg cccacagatt
4114801 gatgaccacc cgacgtccgg ccagcgcgcg ggcgacgtcg acggccgaac cgtcgcccgc
4114861 acacaccacc acaacaccgc gtagtgccgc cgcgcccgga ccgttacctg ccgcgggaca
4114921 gggcggcagg tttgcgcgct gccgggacca agccaatgct tccggggtat cgccgtcgcg
4114981 atgttcgcgc ggggcgggcc gctggctgat cgtgctcgag gcggaatagt catgcagttg
4115041 ggcaaccagc gccgccatca gcgctgccac caccgccagg atcgcgatgg tccagcgggt
4115101 ctttccggtt aacgtcgtca ttgcggtctc agcgggggtt gttggcaggc ttggcattac
4115161 agtccagcca gggccagcag gtgatcggtc tcggggccct ggaccagggg cgccgcgagc
4115221 agcggttcag tggggccaag cccgaaggag gggcagtctt tggcaagcac acaaacacca
4115281 cacgccggtc tgcgggcgtg gcacacccgc cgtccgtgaa agatcactcg gtggctgagc
4115341 aaggtccact ccttgcgttc gatcagctca ccgaccgcct gctccacctt gaccgggtcc
4115401 tctgcggtgg tccagcgcca ccggcgcacc aatcgtccga aatgagtatc caccgtgatt
4115461 ccggggatac cgaatgcgtt acccaggatg acattggcgg ttttgcgccc caccccgggc
4115521 agcgtcacca acttgtccat ggtggccggc acctcaccgc caaaccgctc aactagggcc
4115581 tgccccaggc cgatgagaga ggccgctttg ttgcggtaga agccggtggg gcggatgagg
4115641 ctctcgagct cggtgcgatc cgcctgggcg tagtcccgtg ccgtccgata ccgcgcgaac
4115701 aaggctggcg tcgtcaaatt cacccgtttg tcggtgctct gcgccgaaag tatggttgcc
4115761 acggctagct cgagcggcgt ggtgaagtcc agctcgcagt atacgtgcgg aaatgcctgt
4115821 gccaaagcgc gattcattcg ccgcgcccgt cgcaccaagg cgagccgggt ttctgcagac
4115881 cagcgcccgg gcacgtcggc ggcacgcgcc gctggcttcg atctggatga cttcgccgct
4115941 gtcacctacg acagagtact gatttcgtga tctcactgag acctcgtgtt gattcgaagc
4116001 catgtttact ctccttgtgt catggttgct cgtggcctgc gttcctgggt tgttgatgct
4116061 ggcgaccctc gggttgggac ggctggaaag gtttctggcc cgagacacgg tcacggcgac
4116121 cgacgtcgcg gagtttctcg agcaggccga ggccgtggat gtgcatacgc tcgctcggaa
4116181 tggaatgccg gaggcgctgg attacctgca tcgacgtcaa gcccggcgaa tcaccgattc
4116241 accgccgctt gggtctggcg ctgggccacg gtatgccggg ccgctgtttg tcaccgatct
4116301 cgatagcccc gtcgagccac cccggcatgg ccagcccaat ccgcagttta gaacggctcg
4116361 acacgcaaat cacgtgtagc gttggcacgg cgaaccggtt ggcctacctc tagactcttc
4116421 tcgttggcaa acggttagtg tgcccgtatc acttcgtcgg aaagttgaag aggcaacgtg
4116481 gacgagatcc tggccagggc aggaatcttc caaggcgtgg agcccagcgc aatcgccgca
4116541 ctgacgaaac agctgcagcc cgtcgacttc ccccgtggac acacggtctt cgcggaaggg
4116601 gagccgggcg atcggctgta catcatcatc tcggggaagg tcaagatcgg tcgccgggca
4116661 ccagacggcc gagaaaacct gttaaccatc atgggcccgt cggacatgtt cggcgagttg
4116721 tcgatcttcg acccgggtcc gcgcacgtcc agcgcgacca cgatcaccga ggtgcgggcg
4116781 gtgtcgatgg accgcgacgc gctgcggtca tggatcgccg atcgtcccga aatctccgaa
4116841 cagctgctgc gggtgctggc ccgccggctg cgccgcacca acaacaacct ggccgacctc
4116901 atcttcaccg atgtgcccgg tcgggtggcc aagcagctgt tgcagctcgc ccagcgtttc
4116961 ggcacccagg aaggtggcgc attgcgggtc acccacgacc tgacacagga agaaatcgcc
4117021 cagctggtcg gggcctcacg cgagacggtg aacaaggcac tggctgattt cgctcaccgc
4117081 ggctggatcc gccttgaggg caagagtgtg ctgatctctg actccgaaag actggcccgc
4117141 cgagcgaggt aagcgcgcgc cgcgcgggcg caaccgagcg agctagcttc ctcacgccca
4117201 gcagacacag agtcgcacgc aaacgacgga ttttgtgcga ttgtgcggct gctcgcgcta
4117261 ccgagtccgc agatagtcca gttgtgcctg caccgaccat tcggccgcat tccaaagctt
4117321 ttcgtcaacg tcgaggtaga cgtgttcgac gacctcgcgg accgtggcgt cgtcaccgag
4117381 atcccgcaac gcggcgcgta tctgctccag acgttcgtgc cggtgcagca ggtatcccga
4117441 tgcaatcgct tccaggtcga gcaagtccgg cccgtgcccc ggcagcacgg tccgccggcc
4117501 caggccacgc agccggtgca gcgattccaa gtagtcggct aggctgccgt cttccttgtc
4117561 gatgacggtg gtcccgcaac ccaacacggt gtcggcggtc aacacggcgt cgtcgaggac
4117621 aaatgacagc gaatctgcgg tgtggccagg ggtggccaac acggtaatgg ttaacccggc
4117681 aacgtcgatc acttccccgt cggtcagcgt ctccccatca cgtcgcaaga actgcggatc
4117741 cgcggcccgt accggcgccc cggtcagcgc gaccagtttg tcgatgccgc tggtgtggtc
4117801 gccatgacga tgactgatca gtaccaacgc gatgcggcca agcgcggcaa cccgtgccag
4117861 gtgctcgtcg tcgtccgggc ctggatcgac aacgaccagc tcgtcactga gcgggccgcg
4117921 cagcacccag gtgttggtgc cgtccaacgt cagcaaaccg gggttgtcgg ccaacaggac
4117981 cgacgcggtg tcggtgaccg cgcgcagctg gccgtaggcg ggatgggtca gcgactcagc
4118041 tgtcttcgac atcggccgct agccgacctc cacgatcaac tcgacttcca ccggcgcatc
4118101 caacggtagc tcggatacgc cgaccgccga acgcgcatgc gcgccgctat cgccgaacac
4118161 ctcggccagc agatcggagg ccccgttgat cacgctcggc tggccgtgaa accccggtgc
4118221 cgaagcgaca aacccgacga ctttgaccac ccgggtcacc gcgtcgagat ccaccagcga
4118281 atcaacggct gccagcgcat tgagcgcgca gatccgcgcg agcgtcttgc cctcctccgg
4118341 gttgacgtcg gcgccgagct tgccggtccg caccagcttg cctgcctcca acggcagctg
4118401 gcccgcggtg tagaccaggt tgccggtgcg cacagctgga acgtaggccg ccagcggcgc
4118461 cgccacttgc ggtagcgtga caccgagttg ccctaatcgg gctttagcgc tcattaaccc
4118521 cgatacctcc tacttcgggc gcttcaggta agcgacgtgc tgctcaccgg tgggcccggg
4118581 cagcaccgcc accagctccc agccatcggc tccccactgg tcgaggatct gtttggtggc
4118641 gtgcgtcaac agcgggaccg tggcgtactc ccatgcggtg ggttgggtca tgacgcgagc
4118701 ttatcggtcg gactggaccc gctccgctca gcccggtagc ccggaaagat cgccaggcca
4118761 tcgggctagc atgccatggt ggcaaccaca tctagcggcg gtagttccgt cggctggccg
4118821 tcacgcttgt cgggggtccg actgcacctt gtcaccggca aaggcggtac cgggaagtcg
4118881 acgatcgcgg ccgcgctcgc gctgacgctg gcagcgggcg gccgcaaagt cctactcgtc
4118941 gaagtcgagg ggcgccaggg gattgcgcaa ctcttcgacg tcccgccact gccctaccag
4119001 gaacttaaga tcgcgaccgc cgagcgcggc ggccaggtca acgccttggc aatcgacatc
4119061 gaggccgcct tcctggaata cctcgacatg ttttacaacc tcggtatcgc aggccgggcc
4119121 atgcgccgta tcggcgcggt cgagttcgcg acgacgatcg cgcccggtct gcgcgacgtg
4119181 ctgctcaccg gcaagatcaa ggagacggtg gtgcgcctcg acaagaacaa gctgccggtc
4119241 tatgatgcaa tcgtcgtcga tgcgcctccg accgggcgca tcgcgcgctt cctggatgtc
4119301 accaaggcgg tgtccgatct ggccaagggc ggaccggtgc atgcgcaaag cgaaggcgtg
4119361 gtgaagttac tgcactccaa ccagaccgcc atccatttgg tcactctgtt agaagcgctg
4119421 ccggtgcagg agacactgga agccatcgag gagcttgcgc agatggaact gccgatcggc
4119481 agtgtgatcg tgaaccgcaa catccccgcc catttggagc ctcaggactt ggcgaaggcc
4119541 gccgagggcg aggtcgatgc agactcggtg cgggccgggt tgttgacggc cggggtcaag
4119601 cttcccgacg ccgatttcgc cggcctgctt accgagacca tccagcatgc cacccgaatc
4119661 accgcacgcg ccgaaatcgc acaacagctt gacgccttgc aggttccgcg attggaattg
4119721 ccgacggtct ctgacggcgt cgaccttggc agcctctacg agctctcgga atcacttgcc
4119781 cagcaggggg ttcgatgagt gtcacaccga agaccctcga tatgggcgca atcctggccg
4119841 acacatccaa ccgggtggtt gtgtgctgcg gcgccggtgg ggtcggcaag accactaccg
4119901 cggccgcgct ggcgttgcgc gcggccgagt atggccgcac tgtggtcgtt ttgacgattg
4119961 acccagccaa gcgattggca caagcactgg ggatcaacga tcttggcaac acaccacaac
4120021 gcgtgccatt ggcacccgag gttcccggcg agctacacgc gatgatgctc gacatgcgcc
4120081 gcacgtttga cgaaatggtt atgcaatact ctggacccga acgggcgcaa tcgattctgg
4120141 acaaccagtt ctatcagacc gtcgccacat cgcttgccgg cacccaagag tacatggcta
4120201 tggagaagct gggccaactg ctaagccagg accgctggga cctgattgtg gtagacactc
4120261 cgccgtcgcg taacgcgctg gacttcttag acgcgccaaa gcgactgggc agcttcatgg
4120321 atagtcggct gtggaggctg ttactcgctc ccggccgggg catcgggcgg ctgatcaccg
4120381 gcgtgatggg attggccatg aaggcgttgt ccaccgtgct cggttcccag atgctggccg
4120441 acgcagcagc gttcgttcaa tcgctggacg ccacgttcgg tggtttccgc gagaaggcag
4120501 accgcactta cgcgttgttg aaacggcgcg gcacccagtt cgtggtggtg tcggcggccg
4120561 aacccgacgc actgcgcgag gcgtccttct tcgtcgaccg gctatcgcag gagagcatgc
4120621 cgctagcggg gctggtcttc aaccgcacgc acccgatgct gtgcgcattg ccgatcgagc
4120681 gggcaatcga cgccgccgaa acgttggatg ccgagaccac cgactccgac gccacatcgc
4120741 tggccgcagc ggtgctgcgt atccatgccg agcgcgggca gacagccaaa cgggagatcc
4120801 ggctgctgtc ccggttcacc ggagccaacc ccaccgtgcc ggtcgttggg gtaccgtcgc
4120861 tcccgtttga cgtctctgac ctggaagcgc tgcgggcgct cgccgaccag ctcaccacgg
4120921 tcggcaacga tgcgggccgc gcagcgggcc gctgaggaac cggcccatca gtgacggtcg
4120981 gcaacgatgc gggccgcgca gcgggccgct gaggaaccgg cccatcagtg acggtcggcg
4121041 acgatgcggg ccgtacaaca tctgaccggg atccggctat tgggcacaag ccagttccta
4121101 ttgggcacaa gccaattaga aatgaatggc ttttgctgta accaaaccgt aatcagaagc
4121161 gacgggaccg cggcacctat ccgcagtccc tgagtggcta tccggcggtg ccggtgcggc
4121221 gcttgcgctt ctcaaggtag tccgaccacg aaaccacctc gggatgttgc ttgagcagag
4121281 ccctgcgctg gcgctcggtc atgccacccc aaacaccgaa ctcgaccttg ttgtccagcg
4121341 catctgccgc acactcttgc attaccggac agtgacggca gatcaccgcg gccttgcgtt
4121401 gtgcggctcc tcgaacaaag agttcgtcag ggtcggtagt ccggcacagc gccttggata
4121461 cccacgcgat ccgctcttcc gcgtctacgc tgcgtaccac gttctgtgca gccgtgaggt
4121521 tagtccttcg agcggctgga cgggttcctg acacgagctg atcccttcct cccggccgcc
4121581 gtgtgcgacc gccctcctcg gaaacagccg atgctgcgag cgacgccaca ccatgcacat
4121641 cggtgttacc tgtatctcac tgatctgtat aagtcaggtg gtcgtgtgcc aattgcgcaa
4121701 cagtacgata acgctttttt gggacgagcg tgccgtcttg tctggatcgg ccgggggaaa
4121761 tgccgccgct tcggtcccgt ttacggggtc tgaccagtga cgcagccgca aatatcgcgc
4121821 ccgccccgat cccgcagtga ctcacccgcc cgcggaaaga ttctattgga ccgagcggca
4121881 cggtggagtg acaggaggtc gctactgtag tacgcatgcc cgagcgcctc ccggccgcga
4121941 tcaccgttct gaagctggct gggtgctgtc tgttggccag tgtcgtcgcc actgcgctga
4122001 cgttcccgtt cgcaggcggg ctagggctga tgtccaatcg tgcctctgag gtcgttgcca
4122061 acggctcggc ccagctgctc gaggggcaag tgcctgcggt atcgacgatg gtcgacgcga
4122121 agggcaacac gatcgcgtgg ctgtactcgc agcgccggtt cgaggtgccc tcggacaaga
4122181 tcgccaacac gatgaagctg gcgatcgtct cgattgaaga taagcggttc gccgaccaca
4122241 gcggcgtgga ctggaagggc accctgaccg gcctggcggg ctacgcgtcc ggcgacctcg
4122301 acacgcgcgg cggctcgacg ctcgaacaac agtacgtgaa gaactaccaa ctgctggtga
4122361 cagcccaaac cgatgccgag aagcgagcgg ccgtcgaaac cactccggcc cgcaagcttc
4122421 gcgagatccg gatggcactc acgctggaca agaccttcac aaaatctgaa atcctgaccc
4122481 gatacttgaa cctggtctcg ttcggcaata actcgttcgg cgtgcaggac gcggcgcaaa
4122541 cgtacttcgg catcaacgcg tccgacctga attggcagca agcggcgctg ctggccggca
4122601 tggtgcaatc gaccagcacg ctcaacccgt acaccaaccc cgacggcgcg ctggcccggc
4122661 ggaacgtggt cctcgacacc atgatcgaga accttcccgg ggaggcggag gcgttgcgtg
4122721 ccgccaaggc cgagccgctg ggggtactgc cgcagcccaa tgagttgccg cgcggctgca
4122781 tcgcggccgg cgaccgcgca ttcttctgcg actacgtcca ggagtacctg tctcgggccg
4122841 ggatcagcaa ggagcaggtc gccacgggcg ggtacctgat ccgcaccacc ctggacccag
4122901 aggtgcaggc accggtcaag gccgccatcg acaagtacgc cagcccgaac ctggccggta
4122961 tttccagcgt gatgagcgtg atcaaaccgg gtaaggatgc gcacaaggtg ttggccatgg
4123021 ccagtaaccg caaatacggg ctggatctag aagccggcga aaccatgcgg ccgcagccat
4123081 tctccctggt tggcgacggc gccgggtcta tcttcaagat cttcaccacg gccgctgctc
4123141 tggacatggg catgggtatt aacgcccaac tcgacgtgcc gccccgattc caggccaaag
4123201 gtctgggaag tggcggggca aaggggtgcc ccaaagagac ctggtgtgtg gtgaacgccg
4123261 gcaactaccg cggctcgatg aatgtcaccg acgcgctggc aacctcgcca aacaccgcgt
4123321 tcgccaagct gatctcgcag gtcggggtgg ggcgtgcggt cgatatggcc atcaaactcg
4123381 ggctgaggtc ttatgcgaat cccggcaccg cacgcgacta caaccccgac agcaatgaga
4123441 gcttggctga cttcgtcaaa cgacagaacc tgggttcgtt caccctcggc cccatcgagt
4123501 taaacgcgct ggagctgtcc aacgtggcgg ccacgttggc atccggcggc gtgtggtgcc
4123561 cccccaaccc aatcgaccag ctcatcgacc gcaacggcaa cgaagtcgcg gtcaccaccg
4123621 agacgtgcga ccaggtggtg cccgcagggc tggcgaacac cctcgccaac gcgatgagca
4123681 aggacgccgt gggcagcggc acggcggccg gttcggccgg cgcggcgggc tgggatctgc
4123741 cgatgtccgg caaaaccggc accaccgagg cgcaccggtc ggccggcttc gtgggcttca
4123801 ccaaccgcta cgcggcggcg aactacatct acgacgactc cagctcgccg acagatctgt
4123861 gttccggccc gctgcgccat tgcggcagcg gcgacttgta cggcggcaac gagccatccc
4123921 gcacctggtt cgccgcgatg aagccgatcg ccaacaactt cggcgaagtg cagctaccac
4123981 cgaccgatcc acgctatgtc gacggcgcac caggctcacg ggtaccaagc gtggccggtc
4124041 tggatgtcga cgccgcacgc cagcgcctca aggacgcggg cttccaggtc gccgaccaaa
4124101 ccaactcggt caacagctcc gccaagtatg gtgaggtggt cggaacgtcg cccagcggtc
4124161 aaacaattcc gggttcgatc gtcacgatcc agatcagcaa cggcatcccg ccggctccgc
4124221 ctccgccacc gctgcctgag gatggtgggc cgccaccgcc ggtcggatcg caggtggtgg
4124281 agattccggg gctgccgccg atcaccattc cgctgctggc gccaccaccc ccagcgcctc
4124341 ccccgtaggc cctcccaatc ggcctcgtgc cgctgcagac gcgcgatcag acctcgaccg
4124401 gcagtaggct gcgtgcatgg ctgctgtctt gcccaccttg atccgcaccg gcgccgtggc
4124461 gttgggctcg gccatcgccg ggattggtta cgctgcgctg gtcgagcgca atgcattcgt
4124521 cctgcgcgag gtgaccatgc cagtcttgac tccgggctcc acaccgctgc gggtgctgca
4124581 catcagcgat ctgcatatgc tgcccaacca gcaccgcaaa caggcctggc tgcgcgagct
4124641 cgccagctgg gagccggatc tggtcgtcaa caccggtgac aacctggctc accccaaggc
4124701 ggtgcccgcc gtcgtccaaa ccctgagcga tctgctgtcc cggccgggtg tcttcgtgtt
4124761 cggcagcaac gactactttg ggccgcgcct gaagaaccca atgaactatc tgaccagccc
4124821 ggatcaccgc gtccgcggag cagcgctgcc ctggcaggat ctgcgggcgg cgttcaccga
4124881 acgtgggtgg ctcgacctaa cccatacccg ccgcgagttc gaagttgccg gtctgcacat
4124941 cgccgctgcg ggcgtcgacg acccgcatat cgaccgagac cgctacgaca ccatcgccgg
4125001 cccggccagc ccggccgcca acctgcggct ggggctcacc cattcaccgg agccgcgggt
4125061 gttggaccgc ttcgccgccg atggttacca gttggtgctg gccggccaca cccacggcgg
4125121 gcagctgtgc ctgccgttgt acggggcgct ggtcactaac tgcggtctgg accgctcccg
4125181 ggccaaagga gcgtcacact ggggtgcaaa catgcggctg cacgtctccg ccgggatcgg
4125241 cacttcgccg tttgcgccgg tgagattctg ctgccggccc gaagcaaccc tgctgacgtt
4125301 gatcgcgacc ccaatgggcg ggcgcgattc gagcagcaac ctgggccgct cacagccgac
4125361 agtgtcggtg cgttgagcgg cggggcctgt atcgcggtcc gcagcctatc ccggagctgg
4125421 acggacaacg cgatccggtt gatcgaggcg gacgcccgcc gtagcgccga cacccacctg
4125481 ctgcgctacc cactgcccgc tgcctggtgc acggatgtcg acgtcgagct gtacctcaag
4125541 gacgagacga cccatatcac cggcagtctc aaacaccggt tggcacgttc gttgttcctc
4125601 tatgcgctat gcaacggctg gatcaacgag aacaccacgg tggtggaggc atcgtcgggt
4125661 tcaacggcgg tgtccgaggc ctatttcgcg gcgctgctgg gtctgccgtt catcgccgtg
4125721 atgccggccg cgaccagcgc ttccaaaatc gcgttgatcg aatcacaagg tggccgttgt
4125781 catttcgtcc agaattcaag tcaagtgtac gccgaggcgg agcgcgtcgc caaggaaacc
4125841 ggcggccact atctggacca gttcaccaac gcggagcgcg caaccgactg gcgcggcaac
4125901 aacaacatcg ccgagtcgat ctacgtgcaa atgcgcgaag agaagcaccc caccccggaa
4125961 tggatcgtcg tgggtgcggg caccggcgga accagcgcga cgatcggccg ctacatccgc
4126021 taccgacggc acgcgacccg gctgtgcgtc gtcgatccgg agaattccgc gttcttcccc
4126081 gcgtactccg aaggccggta cgacatcgtc atgcccacat cgtcccgtat cgagggcatc
4126141 ggccggccgc gggtcgagcc gtcgtttctg cccggtgtgg tcgaccgcat ggtggcggtc
4126201 cccgacgcgg cgtcgatcgc tgccgcccgg catgtcagcg ccgttctggg gcgccgagtg
4126261 ggaccgtcta ccggcaccaa cctctggggc gcgttcggac tgctcgccga gatggtcaag
4126321 cagggccgca gcggctcggt ggtcacactg ctcgccgaca gcggcgatcg ctacgccgac
4126381 acctactttt ccgacgagtg ggtcagtgcc caggggctcg atccggccgg gccggctgcg
4126441 gcgctggtgg aattcgagcg ctcctgtcga tggacgtgac ggtcggacct gcggtttggc
4126501 tagtcaacgg tccggtgcga taggctgtcg tggcttcaag cggggtgtgg cgcagcttgg
4126561 tagcgcgctt cgttcgggac gaagaggccg tgggttcaaa tcccgccacc ccgaccgaga
4126621 gatcgctgac gacagcctta cccggcgcag cgtggtagct tgctgcagtc tgctcgggcg
4126681 gcagcgccac cctgacggtg ctggttgacc atgccggaca gcacgtcaac gcacaggcat
4126741 ttccaacgga agttgtaggt taccggccgc cctaaaacac ggtgcacttt tcgttaaagg
4126801 ttgtgggtgt ggatccaacg aaattcgttg ccccggcgtg ggcagcgccg tgtccacagg
4126861 gggacccgcc gcgcattacg cctatgggcc cacccccgta ccgcgggagt tggctctgca
4126921 ccccgagcca atcatgcttc tctcggagtc cgacgcggga ctgggacgac tcgcatgagc
4126981 cggacgcctc ctgcctgacc cccacctgct aggaacgtaa accgggagag tttcgtcgga
4127041 gccagaattg gatttcctcc ccgagcaatc ggcccgaaac cgcggggttg tttccgccga
4127101 ccgtcgacaa catgtggcgt gcgttggatg actgggaaat gtatctccac gacgcagcgc
4127161 cacaactgcc gctcttgatc cgttgcgccc tggtgcatta ccaattcgag gcgatcgggc
4127221 catttctcga cggcaacgca cgactcgggc gtctgttcat catcctttgc cttgttgcat
4127281 tgggacggtt gccgctaacg ggcggggcga aaccgcaccc gagtgccgcg gcggggcaca
4127341 agcatgatgg agcgccgcac gatccgctct ggctcgtcgt cgacggcggt gaactcgccc
4127401 tcgcgcagca gcacgtgcaa tacggtgatc aactctcgca tcgaaaagtt cgcacccaga
4127461 cagcgtttca cgccgccgcc gaacggaacc caggcatagg tttgcggccg cgtaccgagg
4127521 aaccgctcgg ggcggaactc gtgtgggtgc tcatacacct cggcgctgcg gttgatcgcg
4127581 atgatgtgga ccacgattcg tgtgccagcc tccacacggt aaccgccgat ggttagtggt
4127641 tgcgcggcga cacgagccgt caacggcgcg ggcggacgca cccgcaacgt ctcgttgatc
4127701 accgccgtcg tgaaggcttc cccaccgcca acggcctccg ctcgcacgcg ccgcaacgcg
4127761 tccggatggt gcagcagcaa gtcgaacgcc cacgccaacg tggtcgccgt ggtttcatgc
4127821 cccgccagca cgagggtgat cagatcgtcg cggatctcgc tgtctgacaa ctgttccccg
4127881 gactctccgc gcgcgctcac gagcaacgac aggacgtcgt gtcgctcgcc caggcgtgga
4127941 tcggcgcgcc gctgcgcaat gagcgccatg acgacgtcgt cgatctcggt gttggcgcgg
4128001 gcgcgtgcag gccagactcg tagtgcgccc aaccgacgca gtgcgtagcg cacggtcaac
4128061 tgctctgaaa caccaagatt caacagccgc tcgaacggcc ggcccaagcg ccggacctcc
4128121 tcggggtcgt cgaccccgaa tatgaccttg acgatcacat ccagcatcag cgaccgcgcc
4128181 accgtcaaca tcgcaaacgg acggtcaacc ggccatgtat gcatcgccgc gcgagtggag
4128241 ttctcgataa tcggaacgta acgatccagc gcagcgccat gtaatggcgg cgtcaagagt
4128301 tttcgacgtc gaagatgctc cggctcctcc tggacaaaca tcgaccccga cccatagatc
4128361 gccgctgccg gccccacccc ctcgcccccg agcaggacgt cggtgggagc ggtgaaaacc
4128421 tccttggcca gcgccgagtc ggacacgatc gcaacgtcac ccaggctgag aatgggcatc
4128481 gtcatgatcg gtccgtaccg acggatcagt cgcagcatcc ggcgctcgcc acccgccagg
4128541 taggcaaccg cgtaggcggc cgcgaaggcc gcgcgaaatc cacggggcgc cggcaagccc
4128601 ggtgggccgc ccaaagcatc cggcgcgtgc tcccggcgaa ccgcaaacgc tgccacgcct
4128661 acgacagaag cacagcgttt cgggtcggtc aacgcagcag ggctagcaag cgacctcagc
4128721 accatcggtt cccgaaggtg cggtccggcg ctaccgcgtc gaaaatcgca gaccgcgcca
4128781 gccggttggg aatgaggccg tttcaccggc gggcgtcccg cgcagcgttt cgccgcagac
4128841 cctatgttgg ccatgcgcga tataggccac ccggcaccaa ggtgccatga ccgccacaac
4128901 cagggccgcg gcggcaaccg ccaggtgtcc gatcgtcagc gcaactaaac ccgcaaccag
4128961 cccgacagcc cacacggcag ccaccaccag ccccggcaca ttgacactcg cggggacgct
4129021 gccgctaccg cttggctgcg gcgcggatgc atgatcaccg gcgtcactcc cggtgtagac
4129081 catgaccact cccagcgata aaaggttgcc gatcaaggta acccatacag gccgtcggca
4129141 gccaccggcg aacagctctt cgaggatgcc gtcaggacat tgacagctac cagacaccat
4129201 ttccacaccg tcaaaatgtg gcgcgtgaca cgcacggcgg cacgctggca acgtggcgtg
4129261 cgccgcaggc ctcgactatc tggtgccgat cacagcatgc atgctcgtcg gtttgtacgg
4129321 cgttaccggt cgatcctgcc gccccgtacc ccagtcaagg catcgtggag cgtggaaaac
4129381 aaccgaaagg tcttgtccag acccatcaga tgaatcggcc ttctggttac cgaaccccgt
4129441 gcaaccaccc cgaacttgac ggattggcct atcttttcgg atgttgccgc caaaatcttc
4129501 agccccaccg accccagaaa ctccaccgcg gaaaggtcga tgactagcgc cgtcggattg
4129561 tcggccacaa cttcgccgat ggcctcttca agtgccgcag cggtgatcaa atcaatctca
4129621 ccaccgatgc tgagcacggc gaccccgtta tggtcggcaa ccgtgacggt gatcgagtcg
4129681 ggagctgaca atggcgatcc tcttgtccga gccgtccgtg tggtgaaagc ctagcccgcc
4129741 tgcgaactgc ggcggcggcc catcagcgta ggatttgccg gctgcacacg acctgtgtgc
4129801 gggccgcaat cgcggcgaag gcgctggggc gtgggtgaat tgcctaacaa ccctcgagtg
4129861 cggacacgca tatagcctcc gtcgaaattg gcctataggc gttccttgac cgccgccgac
4129921 aagcgtgcgc cgtcggcttt cccggcggcg atcacggtgg ccgccttcat taccagaccc
4129981 atctgtttca tgctgggccg atgcccgagt tcttcggcca cctcggctat ggcggtgtcg
4130041 gcgacatcgg ccagttcccc ctcggtgagc ggcgtcggga ggtactcgtc aatgatccgt
4130101 gcctcggcat gctcggtggc ggcgagctca ccgcggccgt tttgggtgta gatctccgcc
4130161 gcctcaccac gcttgcgcga ttccctggcc aacaccttga tcacctcgtc gtcggagagc
4130221 tctcttgcct gcttgccaga gacctcctcg gtctggatcg cggccagcag catgcgtatg
4130281 gtcgcggtcc gcagcttgtc ctgcgtcttc atcgcttggg tcaggtctga ccgaagctgg
4130341 gatttaagtt ccgccattgc acaaacgcta cgcgccgcaa cgcccgaaac ccgacactga
4130401 gacctacatt gagaaatgca ccgaccgccg acaggatgga ggccatgacg aacgacgaca
4130461 gctgctgcgt ccggtgagca tgctgccgcc tggctacccg gttgaaccac cgcccgtggc
4130521 gccgggatat gcgccggccg gatatccgcc ctaccccgct acaccacccg ggtacggccc
4130581 gccgggttat ggtgcgccgc ccagctatgg ccccccgcct ggctatggtc cacccctcgg
4130641 ctaccccgcc gcaccgcccg gctgcggccc accgcccggc tatggcccac cgctcggcta
4130701 tggcccaccg gtcgccccgg gcgcggtcaa accaggaata atcccgctgc ggccgttgac
4130761 cttgagcgat atcttcaacg gcgcggtcgg ctacatccgc gctaacccga aggcgacgct
4130821 gggattgacc gccatggtcg tggtgaccct gcaaatcatc tcactggtgg ccctatttgg
4130881 ccccatgacc gccttcggtg acatcgtgac cggggagccc gacgagctga ccggcgcggt
4130941 ggtgggcggt tggtcagcgt cattcggcgc cagtctcctg gtcagctggc tagcgggtgt
4131001 gctgctcagc ggcatgctca ccgtcatcgt cgggcgggcc gtgttcggtt cgccgatcac
4131061 cgtcggcgag gcgtgggcca aggttcgcgg tcgcctgctc gcgttgttcg gcctggcact
4131121 gctggaagca gccggcgtgg tggcggtgct cgggctggcg gtcgtcatac tttccggggt
4131181 cgcggcggcg gccaacgagg cagcggcggc cctcctcggc ttcccgctgc tgctcgtggt
4131241 tggggtgtcg ctggcctatt tgtatgtcgt cctgctgttc gcacccgtgc tgatcgtgct
4131301 ggagaggctg cccatcgtcg aggcgatcac cagatccttt gcgctcgtgc gtcatggctt
4131361 ctggcgggtc ctgggcatcc gcctgctgac ggtgctggtg gtgggcgtag ttggtaatgc
4131421 gatcgcggct cctttcatga tcgtcggcga gatagtgacg gccgtcacag cgtccgacgg
4131481 gtcagtcacc atgcggctcg tcggcgctac gctctcggcc atcggagtga cgatcggcca
4131541 gattgtcacc gcgccgttca gcgccggagt tgtcgtgctg ttatacaccg accgccgtat
4131601 ccgtgccgag gccttcgacc tggtattgca gaccggctta gaagccggcc ccgccggcgg
4131661 gcccgccccg gtggagtcca ccgacaacct atggctcacg cggcctttct aaagggagtt
4131721 agtgaggaca ggctgacagt gccctccatc gacatcgacc gcgaagccgc acaccaagcc
4131781 gcacaacgcg agctcgacaa accgatctac cccaaagact ccctgaccaa ggaactcacc
4131841 gactggatcg acgagcagct gtaccggatt ttggagaagg gatcctcgat acctggcggt
4131901 tggttcacca tcaccgtgct gctcatcttg ctgatgatcg cggtgaccgc cgccgtccag
4131961 atcgcacggc gcaccatgcg caccaaccgc ggcggtgact accagttgtt cgacgccggc
4132021 caattgaccg cagcccagca tcgctccacg gctgaaagct atgccgccga gggtaattgg
4132081 gctgcggcga tccgccaccg gctacaagcc gtggctcgcg agttggagga gaccggcatg
4132141 ctcaacccgg ctgccgggcg caccgccaac gagctggcca gcgatgcggg cgaggtttta
4132201 ccgcatctgg caggggaatt gacgcaggcg gcaaccgctt tcaacgacgt cacctacggc
4132261 gagcggcccg gaacccaagg cgcctaccaa atgatcgccg acctcgatga ccatctgcgg
4132321 tcccgttcac cggccgtcgt atctgcagtg cagcacccgg ccgtgttcga ctcgtgggcg
4132381 caggtccggt gattcccaca cgtctcgcaa ccgtgcgccg ccgacggccg tggcgcgggg
4132441 tgttgctcac gctggccgca gtcgccgtcg tggcctcgat cggcacctat ttgacggcgc
4132501 cacggcctgg aggcgccatg gcccccgcgt ccaccagctc gacggggggc cacgcgctgg
4132561 cgacgctgct tggcaaccac ggcgtcgagg ttgtcgtggc cgactccatc gccgatgtcg
4132621 aagccgcggc acgccccgac tcgctgctgt tggtggcgca gacgcagtat ctagtcgaca
4132681 acgcactgct ggatcggctg gcgaaagccc ccggtgacct gttgctggtg gcacccacct
4132741 cacgaactcg tacggcgctg acgccgcaac tgcgcatcgc ggccgccagc ccattcaaca
4132801 gtcagccgaa ttgtacgctg cgggaagcta atcgggcagg atcggtgcag tgggggccca
4132861 gtgacaccta ccaggccacc ggcgacctgg tgttgaccag ctgttacggc ggggcattgg
4132921 tccgctttcg tgctgagggc cgaaccatca cggtggttgg cagcagcaac ttcatgacca
4132981 acggcggcct gctgccggcc ggcaatgccg cactggccat gaacctcgcg ggcaaccggc
4133041 ctcgtctcgt ctggtacgcg cccgaccaca ttgaggggga aatgtcttct ccgtcatctc
4133101 tttccgacct gattccggag aacgtgcact ggaccatctg gcaattgtgg ctggtggtgc
4133161 tcttggtggc actctggaaa ggccggcgga tcggtccact ggtggccgag gagttacccg
4133221 ttgtgatccg cgcgtcggag actgtcgagg gtcgcggtcg gttgtaccga tcccgtcggg
4133281 cgcgtgatcg cgccgcggac gcactacgca ccgcgacgct gcaacgcctg cggccccgac
4133341 ttggggtggg cgcaggcgcg ccggcgccag cagtggtgac aaccatagcg cagcgcagca
4133401 aagctgaccc gccgtttgtt gcctaccatt tattcggccc ggcaccggcc accgacaatg
4133461 acctgttaca acttgcccgt gcgctcgacg acatcgaaag gcaggtcacc cactcgtgac
4133521 acagtccgcg tccaacccgc aagctcctcc cacccaaacc cctggcgctg aattgcccgg
4133581 ctatcccccg caagcgggtg gtgcccctac agcggcccct tccgggccgc atcctcaccg
4133641 ggctgaagca gaatcggcac gtgatgcatt gctggcatta cgcgccgagg tcgccaaggc
4133701 cgtcgtcgga caggacgggg tgatcagcgg cctggtgatc gctctgttgt gccgtgggca
4133761 cgtgctcctg gaaggtgttc caggagtggc gaagacgctg attgtccgcg ctatgtccgc
4133821 cgctttgcaa ctggagttca agcgggtgca gttcacccct gacctgatgc caggcgacgt
4133881 caccggttca ctggtctacg atgcccgcac cgccgagttc gtgttccggc cgggcccggt
4133941 gttcaccaat ttgctgctgg ccgatgagat caaccgcacc ccacccaaga cgcaggccgc
4134001 gctgctcgag gcgatggaag agcgtcaagt cagtgtggag ggtgagccta agccgctgcc
4134061 caacccgttc atcgtcgccg cgacgcagaa cccgatcgaa tacgagggca cctatcagtt
4134121 gcccgaagcc caactggatc gtttcctgct gaaactgaat gtgacactgc cggcacgcga
4134181 ttccgagatc gccatccttg accggcacgc gcacgggttc gacccgcgcg atctatccgc
4134241 gatcaatccg gtggccgggc cggccgagct ggcggctggc cgcgaggcgg tgcgccacgt
4134301 gctggtcgct aatgaggtgc tgggctacat cgtcgacatc gtcggggcca cccgctcctc
4134361 gcccgcacta cagctcggtg tgtcgccgcg tggggcaacc gccctgctgg gcaccgcccg
4134421 gtcctgggcg tggctgtccg ggcgcgatta cgtcaccccc gacgacgtga aggcgatggc
4134481 ccgaccgacg ctacgccacc gggtgatgct acgcccggaa gccgagctgg aaggcgccac
4134541 acccgacggc gttctcgacg gaattctggc ctcggttccg gtgccccgct agtgatccgt
4134601 gtgatcggcg ccggcgacga tgcagtgggg gcaccacccg cttgcggggg acgaagcgat
4134661 ggggtggggg tacgccccca caagtgggag gtacccccac ccgcttgcgg gggagagcgg
4134721 cgcagatgat cctaaccgga cgcaccggct tgctggccct gatctgcgtc ctgccgatag
4134781 cgctgtcccc ttggccggca agggctttcg tgatgttgct ggtggcgctt gcggtagcgg
4134841 tgaccgtgga caccctgcta gcggccagca cccgtaagtt gcgctttacc cgctcgccgt
4134901 atacctccgc ccggctcggg cagcccgtgg acgcgagcct gctgctctgc aatgggggcc
4134961 gccgccggtt ccgcggccag gttcgtgacg cctggccgcc cagtgcccgt gcgcagccgc
4135021 acacccacga tgtcgacgtg gctgccgggc agcgccagca ggtgcacacc gcactgcggc
4135081 cagttcggcg tggggaccag cgcgcagcaa tggtcacggc ccgttcgatc ggaccactgg
4135141 ggttggcggg acggcagagt tcacagtcgg tgcccggctt ggtccgggtg ctgccgccgt
4135201 tcctgtctcg caagcacctg ccgtcgaggc tggccaagct gcgggagatc gacgggctgt
4135261 tacccacgtt gatacgcggc caaggcaccg aattcgattc gctgcgcgag tatgtcgtcg
4135321 gcgacgacgt ccgctcgatc gattggcgcg cgagcgcacg ccgcgccgat gtcatggtcc
4135381 gcacctggcg gcccgaacgg gaccgccgag tcgtcatcgt gctcgacacc ggacgcatgg
4135441 cggcggggcg ggtcggtgtc gacccgaccg ccgccgatcc cgccgggtgg ccgcggctgg
4135501 actggtccat ggatgccgca ctgctgttgg cggcactggc gtcacgagcc ggcgaccatg
4135561 tcgacttcct ggcccacgac cggatcagcc gcgccggcgt gtttggcgcc tcgcgtagcg
4135621 aactgcttgc ccaactggtc gatgccatgg ccccgctgcg accggcgctt atcgaatccg
4135681 actggcatgc aatgattgcc accatcttgc ggcgcacccg gaggcgatcg ctggtggtgc
4135741 tgctgaccga cctcaacgcg accgctctcg acgagggcct gttgccggtg ctgccgcagt
4135801 tgtcggcccg acaccatgtg ctggtcgccg cggttgccga cccgcgcgtc gatcaactgg
4135861 ccgccgggcg gtccgacgcg gcagcggtgt acgacgctgc ggctgcggag cgcgcccgca
4135921 acgaccggcg tgcgatcgcg tcacaactgc gccgaggcgg ggtagatgtc atcgacgctc
4135981 ctcccgccga aatcgcaccc ggacttgcgg atcgctacct ggcgatgaaa gcgaccggcc
4136041 gcctctaatt tccgacctcc attgtgaaat gtgcgacgcc agcgcggcgt gtcgtgtcgc
4136101 gagtttcact ctcgggggag ttcagccggt cgggaccacg tcgggcgcgt cctccatgtc
4136161 gccggtctcc ccggcttgcg cggcacgacg accgaagtag ccgatgtagg acagaaacac
4136221 cgcctcggcg atgatcccga cggcgatccg aacaaacgtc ggcaacggcg acggtgtcac
4136281 caccgcctcg atcagacctg cgaccagaaa cacacccacc aagcccaccg cgaccgacac
4136341 gacaccacgt ccttgctcgg cgaggacctg tccgcgcggg cggttgcctg cagatatcac
4136401 cgaccacccc agccgcatcc caatcgccgc ggcgagaaag acggccgtca gctccagcag
4136461 cccgtgcgga agaagcaggc ccagcaggaa atcgcccttc cccgcctgga acatcagccc
4136521 ggcgatcagt ccgacgttgg cggcgttatc gaagagcacc agcggtatcg gcagccccag
4136581 cacaacagac atcgcgatgc acgtggtagc cacccaggag ttgttcaccc agacctgcag
4136641 agcgaacgac gcggccgggt gctcgctgta ataggactgg acgtcatggc tgaccaattc
4136701 gtctatctca gtgggcgtcc cgatcgcgga ctgcacctcg tgactgccgg ccacccagaa
4136761 cccgatcagc accacgacgg cgaaaaacgc caccgcagtc gccagccacc accgccaggt
4136821 acggtaggcc acgaccggga acgacactgt ccagaaccga atgaacgtac gggtcagcgg
4136881 tgcgtgcgcg cctgtgaccg cggaccgagc ccgcgcgact agactcgaca gccgaccggt
4136941 catcaactgg tccgacgaag ccgatctgag catcgacaga tgcgtggaca cacgctgata
4137001 tagctcgacg agttcgtcga tttcggctcc gctcagtgaa tggcgcttct tgatcaagtg
4137061 gtcgagccgg tcccacgtgc cgcggttggt cagcaagaac gcgtcgacgt ccaccctgcg
4137121 cagcctacct aagccgccga gcgtgagcgg tggccaatgc cgagtgcagc agagcaccgc
4137181 accaaagcct gtagcgtttg ttggtatgtc ggaggtggtg accggcgacg ccgtggtgct
4137241 cgacgtacag atcgcccagt tgccggtgcg cgcggtcagc gcggtcatcg atatcaccat
4137301 aatattcatc ggctacatcc tcggtctgat gctgtgggcg accgccctga cccagttcga
4137361 cgaagccttg accaccgcat tcctgatcat cttcacggtg ctggcgctgg tcggctatcc
4137421 cctggtctgg gaaaccgcaa cgcggggccg atcagtgggg aagatcgtga tgggtctgcg
4137481 ggtggtgtca gacgacggtg gcccggagcg gttccggcag gcgctgtttc gcgcgttagc
4137541 gtcggtggtg gagatctgga tgctgctcgg gagccccgcc gtgatctgca gcatgttgtc
4137601 gccaaaagcc aagcgagtcg gcgacgtctt cgcgggcacg gtcgttgtca gcgaacgtgg
4137661 tccgcggttg gggccgccgc cggtgatgcc accgtcgctg gcctggtggg cgtcgtcgct
4137721 gcaattgtct gggcttaccg ccggccaagc cgaggttgca cgtcaatttc tggtgcgggc
4137781 accgcaactc gatcctgcgc tacgcgagca gatggcctac cggatcgccg gtgatgtggt
4137841 tgcccgcatc gctccgccgc cgccacccgg agttccacca cagttggtcc tggccgccgt
4137901 cctcgccgaa cgacaccggc gtgaactgtt gcgactgcgt cccacgctgc ctcccgcagg
4137961 acaggcgcca tgggcccaaa tggcgcctca tcggggttgg ccgcccggtt tgtccggcgc
4138021 cacgccgtgg tctcctcagc agccggtgat cccctggccg gagccagatc cgccaccgca
4138081 agccgctccc tggccgcagc aggcgccgga cggcccggga ttctcgccgc cgggctagca
4138141 gctagtcttc gctgcgccgg atcccccgag cgtgcggaca tgttcaggcg cacagcgaaa
4138201 gctaggacac gtcaacccaa tccagggtcc gctgcaccgc cttgcgccag ccggcataac
4138261 ccgcggcacg ctcgtcgtcg tcccacgtcg gtgtccaccg cttgtcctct cgccagttgg
4138321 cccgcagatc ggacggagcc gcccagaacc cgaccgccaa gcccgccgcg taggccacac
4138381 ctagtgcggt ggtctcggcg accaccggcc gcaccacatc cacacccaac acgtcggcct
4138441 ggatctgcat acacaggtcg ttgccggtga tcccgccatc caccttcaac acctgcaggc
4138501 gaacaccgga gtctgcttcc atggcgtcca ccacatcgcg gctctggtag cagatcgcct
4138561 ccagcgttgc gcgcgccagg tgcgcgttgg tgttgaaccg cgacaacccg acgatcgcgc
4138621 cgcgcgcatc ggaccgccag tatggcgcga acagcccgga aaacgccggc acgaaataca
4138681 tgccgccgtt gtcggggacc tggcgggcca gcgcctcact ctgtgcggcg ccgctgatga
4138741 tgcccagctg atcgcgtagc cactgcaccg ccgagccggt caccgcgatc gaaccttcaa
4138801 gcgcgtacac gggtttagcg ttcccgaatt ggtagcacac cgtggttagc aggccgttat
4138861 tcgatcgcac gatcgtttca ccggtgttca gcagcagaaa attgccggtc ccataggtgt
4138921 ttttcgcctc ccctggggcc agacagactt gaccgaccat ggccgcatgc tgatcaccga
4138981 gaactccggt gatcggcacc tcaccgccga caggcccggt cgccagcgtg acaccgtaag
4139041 gctccgacgg cgccgacgat gcgatctcgg gcagcatggc ccgaggtatc gaaaacaacg
4139101 acaacagctc gtcgtcccag tccagcgtct ctagatccat caacatggtc cggctggcgt
4139161 tggttacatc ggtgacatgc acaccccccc gcggcccgcc ggtcagattc cacaacaccc
4139221 aggtgtccgg tgtgccgaac aatgcgtcgc cgttctcggc ggccgcgcgg actccatcga
4139281 cattttccag gatccactgc agcttgccgc cagagaaata agttgccggc ggcaggcccg
4139341 ccttgcggcg gatcaggttt ccacgaccgt ctcgatccag cgccgacgcg atgcggtcgg
4139401 tgcgggtatc ctgccataca atcgcgttgt agtagggccg tccggtgtgc cgattccata
4139461 ccagcgtcgt ctcacgttgg ttggtaatcc ccaacgcggc aatatctttc ggcgataggt
4139521 tggtggcgtt gagcaccgag atcaacaccg acgcggtgcg ctcccagatc tcgaccgggt
4139581 tgtgctccac ccagccggcc cggggcagga tctgctcgtg ctcgagctgg tggcgggcca
4139641 cctcggcacc gtggtgatcg aagatcatgc agcgggtgct ggtggtgccc tggtcgatgg
4139701 cggctatgaa atccgaggac tcggccaatt gctctcctag gatggcgtcg gacactgcat
4139761 gtaatcgtcc atgatggtcc accgcagcgg cgggtccgac gccgtcagcc ggagaagggg
4139821 tcgcgaattc taatgccctc gaacttgcgg aagtcgcggt cgtgactcca gatcgtggcg
4139881 atgccgtgat ggcgcatgag cgcgacgagg tgggcgtcgg gaaccagatt gcctcgcggc
4139941 ttgaccgggt cggctactcg ccgatagacg ggccagaatc cgttggcctc gccgacctgc
4140001 cgcacgtgcg gtcgtgaggt gaattgctcg atgttttcga cggcgacctc aggcgccagc
4140061 ggcgcaccca acaacgtcgg atgggtgaca acccgtagat aacccagcgc gacgggccac
4140121 aatagatata ccagccctgg cccagccagg aatcgctcaa cgagcgtctt cgccttatcg
4140181 tgaaacgggc tggctcggtg cgtcgcatgg accagaacat cgacgtcaaa ggtttcgctc
4140241 acccacggtc caaaatcgcc caaacagcgt ccttgtcgtc aagatccaca cggggccgca
4140301 agtcggcagt cgaccagcgg atgtcaacgt ttggaggagg ctcggccgcc agagcttgcg
4140361 caagcaattc ggaggcgagc tgccctaacg ttttgcgctc ctcgcgctgg cgtcgtttca
4140421 acgcccgcag tatgtcgtca tcgaggtcga tcgtagtgcg catacatcag atgctaactc
4140481 gatatgcatc tgatgcgaac gatctcaccc ttcttgcgct gccggcacga aacctgttgc
4140541 atcagcaatg tgggcgaaga ggtaacgcgc accacatata gccgcgaaca tcagcgcgag
4140601 taccggcgca aggtgcggct gtgcttggac gtcttcgaga ccatgcttgc gcagaccagg
4140661 ttcgaggccg accggccact caccggcatg gagatcgaat gcaacctcgt cgacgccgac
4140721 taccagccgg ccatgtcgaa ccgctatgtg ctggatgcca tcgccgaccc ggcgtaccag
4140781 accgaattag gcgcttacaa catcgaattc aatgttccgc ctcgcccgct accgggacgc
4140841 acttgcctag agctggagga cgaagtccgc gccagcctca acgatgccga gaccaaggcc
4140901 agctgcagcg gagctcacat cgtgatgatc ggcatcttgc ccacactgat gccagagcat
4140961 ctgaccgacg gctggatgag cgcatcagcg cgttatgcgg ctctcaacga gtcgattttc
4141021 aaggcccgcg gcgaggatat ccccatcaac atcgccggcc cggaaccgct gagctgccat
4141081 gccggatcca tcgcacccga atccgcttgc accagtgtgc aattacattt gcagctagca
4141141 ccggcggatt ttccggctaa ctggaatgcg gctcaggtac tggccggacc gcagttagca
4141201 ctaggtgcca actcgcccta tttcttcggc caccagctgt ggtcggaaac ccgcatcgag
4141261 ctgttcacac agtccactga tgcccgtccc gaggagctga aatcgcgagg ggtgcgcccc
4141321 cgggtatggt ttggcgaacg ctggatcacc tccgtcctcg acttgtttca ggaaaacatc
4141381 cgctacttcc ccaccctgct acccgaggtg tccgacgagg accccctcgc agagctttcg
4141441 gctggacgca tcccacacct gtccgaattg cggctgcata acggcacggt gtaccggtgg
4141501 aaccggccgg tgtacgacgt ggtcgacggg cgcccgcatc tgcggctgga gaaccgggtg
4141561 ctacccgccg ggccgacggt cgttgacatg ctggcgaatc atgccttcta ctacggcgca
4141621 ctacgcggtc tgtccgaggc cgacccccca ttgtggacgc agatgaattt cgctgcggca
4141681 caagcgaatt tcctggcagc cgccaggtac ggcatggacg cccagttgga ttggccgggc
4141741 ttgggcgagg tgacgacgcg ggagttggtg ttgggcacgt tgttgccaat ggcacacgag
4141801 ggactgcggc ggtggggtgt cgacgcggag gtacgcgacc ggttcctggg tgtcatcggc
4141861 ggtcgcgccc agaccggccg caacggcgcg cgctggcagg tcgccaccgt ggcggcccta
4141921 caagacggcg ggctgacccg gcccgcggca ctggctgaga tgctgcgccg gtactgcgag
4141981 cacatgcaca gcaacgaacc cgtgcatacc tgggacacgt agtccacgag taggttggga
4142041 gccatgaccg acgaggtaat ggactgggac agcgcctacc gtgagcaagg cgccttcgag
4142101 gggccgccgc cgtggaacat cggtgaaccc cagcctgagc tggcaacgct gatcgcggcc
4142161 ggcaaggtcc gcagtgacgt gctagacgcc ggatgcggat acgccgaact gtcattggcc
4142221 cttgccgccg acggctacac cgtggtcggc atcgacctca cgcccaccgc cgtcgcggct
4142281 gccaccaagg ccgctgagga gcgcggtttg accacggcca gcttcgtgca ggccgacatc
4142341 acggagttcg cggcttatcc agccggctcc gccggccgct tttccacggt gatcgacagc
4142401 accctgtttc attcgctgcc ggtggacagc cgcgaccgct atctgagctc ggtgcaccgc
4142461 gcggcggccc cgggcgccag ctattacgtg ctggtcttcg ccaagggcgc cttccccgcc
4142521 gagctggaag tcaagccaaa cgaagtcgac gaggacgagt tgcgtgccgc ggtgagcaaa
4142581 tactggaaga tcgacgaaat ccggcccgcc ttcattcatg tcaatccggt cacgattccg
4142641 ccccagctgg ccggagcgcc agtcgaattc ccgccatacg atcacgacga gaagggtcgg
4142701 gtgaagttcc ccgcctatct actcaccgcc cacaaggccg gctgaggcta acgttcgccg
4142761 ctggtcgccg cggtcgccgc gaccaacgcc tcggcgaagg cgtccaggtc atcggcggtg
4142821 ttgtccacgt gcggcgagat ccgcagcacc ggcgccggca gttccagcgg tgcccgctcc
4142881 actccggcgt aggtggtcac gatccgccgc tgcgagagca accaggcccg caccgctgcc
4142941 gggtcggcgc cgtcgatcgg cgccagggtg gtgatcgcgc taggctcgtc gaccgcttcg
4143001 accacccgcc aaccggacac atcggcgagt acggtcctgg cgatgtcgcc cagctcagcc
4143061 aagcgtgccc gaatagcctg cggcccgcac gccagatgct caccgagtgc gaccgaaaac
4143121 cccactcgcg cagctacatt ggcttcgcca aatccgagtt gttgggccac tgtcagcggc
4143181 ggcatccagt ctggcgcggg cagcctcgca cgtaaccgct ccatcagctc aggacgaacc
4143241 gccagcaccc caactccgcg gggcccggcg atccacttgc gcgacgaggc atacgtgacg
4143301 tcggcaccca ccgcacaatc cacgtggccc aggccctgcg cggcatccac gaccagcggc
4143361 agtttcagct cggtgcacag ttgcgccacc atcgccagcg gctgtgcgac gccacggtgg
4143421 ctggccacca cggtcaggtg cactaggtcg ggcgggtcgt cggccaacat gaaggccgcg
4143481 tcgtcgagcg ctaccctgcc gtcctgcaga gttggtaacg gacgcacgtc gaagccatgg
4143541 gcggccatca cagccaggtt cggcccgtat tcgccgggca agcaagccag cgtccggttc
4143601 tccccaggcc agctgcccag cagcagatcc aacgcgtgca gcgagccggt ggtgaacacc
4143661 acctcggcgt cgggcaggcc gctcagtgcg gcgaccgccg cacgtccggc gtcgagcacg
4143721 gcggcggcgg cctcagccgc gacataaccg ccaacctcgg cctcgtgccg cgcgtgctgg
4143781 gctgcggcgt cgagtgcggc gaaactctgg cgcgaacagg ccgcgctgtc caggtgtagc
4143841 cccgcgacgg gcgggcgcgc tgcccgccat cggtcggcca gcgaatcgcc ggcggggctg
4143901 tttgcgccgc ttctcctcat cgcttcgtcc tgcatcgtcg ccggcgcggc tcacttggcg
4143961 gccagcgaca ggccaaagtc accggcttca tcggtccacc atcggatgcg atgcagtccg
4144021 gccgcggcca actcggcacc gaccgcttgc ggccggaact tgcacgagac ctcggtcaac
4144081 atctcctccc cggcgtcgaa gtcgacggtc aggtccagtg caccgacccg tacccgctgg
4144141 cgaccgtcgg cacgcaacca catctcaatc cgctcttctg cgctgttcca acgggcgacg
4144201 tgctggaagg catcgacgtc gaaatccgct tcgagttccc ggttgatcac ggcaagcacg
4144261 ttgcgattga actgagccgt caccccgcca ggatcgtcgt aggcgcgcac cagccgggcc
4144321 gcgtccttga ccaggtcggt gcccagcagc aggctatcgc ccggccgcat taccccggcc
4144381 agggccgtca ggaactgcgc gcgcggcccg ggcgtgaggt tgccgatcgt ggaccccaag
4144441 aacacaaaca ggcgccgtcc tcccctggga atctcggtta aatgctcctc gaaatcccca
4144501 caaacagcgt tgatttcgac accactgtat tcacgctgaa ttgcggtcgc agttgccgac
4144561 agcacgctgg cgtcgacgtc gaacgggacg aatctgcgca gcgatccccg gtggcgcaac
4144621 gcatccagca gcatccgggt cttctccgag gtgccgctac ccaactcgac caaagtatcg
4144681 gcccggcagg cggaagccac ttcggccgat ctggcccgta ggatttcggc ctcggctcgg
4144741 gtcgggtagt actccggcaa ccgggtgatc tgatcgaaca gttcactacc caccgtgtcg
4144801 taaaaccact tgggcggtaa cgatttcggt gtcttctgca ggccagagta cacatcgcgg
4144861 cgcaacgcca gatgccccgc atcctcgccc agatggttgg caaccgacac tctcatcgag
4144921 gtcctttcgc gcggtccaat gcggtcagcg tgacaccctt ttgggttacc tccaccaggt
4144981 ggcggtccgg cacgtcgccc caaccggagt cgtcgtcgta tggttcgctg gccagcacca
4145041 ccccgtcggc gcgccgcagg atggacagcg tgtctcccca ggtggtcgcg atgagccggg
4145101 aaccgttggc cgccaagatg tttagtcggg catttgggtc ggccgcgccg accttgacaa
4145161 tggtgtctcc cagagcgtcc agaccgtgag cgaagatggt ggccgcgagt atcgcgctgt
4145221 cacagaccga ttcggccgcc gggcccgccg gcaacacggc acgatcaacc acaccgttgt
4145281 gcgctagcaa ccagtgccca tcggtgaacg gcggggtcgc gctgacttcg atcggcatac
4145341 cgacagtcgc cgagcgcacc gcggcgagga tgcagtgact acgcagcgcc ggcgccaccg
4145401 agtgaaacga cgtgtccccc cacagcggag ccgggctgcg ccaacgccgg ggaatggcac
4145461 cgtcgaagaa gccgacaccc caaccgtcgg cgttcatcag cccgtgcttt tgccgacgcg
4145521 gcgcatatga ctgcacccgc agaccctgcg gcgggtccag caccaacgaa gaaaccgcga
4145581 cctgtgcccc gagccacccc aggtgacgac acatcagatg tcccacgcca accggacacc
4145641 ggcaaagatc tggcggcgat acgggtgatc ccagttgcgg aagctgggcc gcaggatggc
4145701 cggctccacc gcccacgagc cgccgcgtag cacgcgatag tcgccgccga agaacggctg
4145761 tgagtaccgc tcatagacca tcgggacgaa ccccggccag ggccgcaacg gcgaggtggt
4145821 ccactcccag acatcgccca gcatctgctc ggccccgcac gccgatgccc cggccgggta
4145881 ggcacccacc ggcgcggggc gcagcgtttg accgcccagg ttggcatagg tgtctgtggg
4145941 ctcctcggtt ccccacgggt agcggcggcg ggaaccagtc gccggatccc acgcgcaagc
4146001 cttctcccac tccacctcgg tgggcaaccg cgcgcctgcc caggcggcgt acgcctcggc
4146061 ctcaaagtag ctgacatgct gcaccggctc atcggcggga atgtcctcga cgtgcccgaa
4146121 ccgggtccgc gtccgcccgc ccgacctcca gaattgcgga gcggtcagcc ccgcgcgctg
4146181 gcggtgctgc cagccacgtt ccgaccacca ccgcgactgg gtgtaaccgc cgtcgtcgat
4146241 gaagtcttgc cattcaccgt tggtgaccgg aacccggccg atccggaatg cgggcacgtc
4146301 gacgacgtga gccggacgtt cgttgtccaa tgagcacggt tcgtccgcgg cgtccacgcc
4146361 cagcacgaac gggccgccgg ctaccagcac cgacgttccg gccatcctcg gccgtccggc
4146421 gggcagggcg gaagtcgcgg ccaacagtgg cgagccggtc cgtaggttca aggcctgcag
4146481 catggtttcg tcgtgctggt tttcgtggct gatcaccatc gcgaacacga agctgtcgcc
4146541 gtcttcaggt agagcggcaa gggcatccag cgcagcggag cgcaccgttg cgcagtagga
4146601 ccgcgcccgc gccggggaca gcaacggcag ttccacgcga ctggcgcggg aatgctcgaa
4146661 ggcgtcgtag agaccctcga ccgccggcgg caaaagcccg ggctggcctg ggtcgccgcc
4146721 gcgtagcagc cacaactcct cctgctgacc gatgtgtgcc aggtcccaca ccagcgggct
4146781 catcaacggg tcatactggc agcaaagctc ggcatcgtcg aagtcgacca gccgcaacgt
4146841 ccgcgcccgc gcccgcgcca gatgacaagc cagctgctcg ggtgaagtca cgacgccccg
4146901 tgcatcatcc cggtgacggc tgacgcgatg ccgcccgcga tcacccggtc ggagaaatcg
4146961 tctgccgggc aaacacccct gtcgacgtgg tccaccaacc gctgcatcgc gccgatgagt
4147021 tcagtcggta cccgccgcgc ggcgatggcc aggcatctgt tggctgccag gtagagccgc
4147081 cggtcggcca ggccgatccg ggccgcggtg tcccaggccg tggccaccgg ttcgaccgcg
4147141 tcgaccgcca aatctgccgc caccgggtcg tcgagcagcg tcaccaaggt gaacaccacc
4147201 gcgggccaca cctcgtcggg cacgctgtcg aggtagcgaa tttccagcca ttgccgagga
4147261 cgcaccggcg ggaacaacgt tgtcaggtgg taaaccaggt cggcgacggt agcgcggcga
4147321 ccgtccagca gcacccgacc gtcaacccag tcggtgaagg gcacgtagtc cgtcaccgca
4147381 cgggtgtctt gagtgtccgg gcttcgcacc atcatcaccg gcgccttcaa ggcatactta
4147441 gcccagtcga tgccggggtg gtcgccactg gcaccaagaa tggggccgca gcgcgcggag
4147501 tccatctggc cccacacccg ctgccgggtg gactgccagc cggaaaaccg gccgcccagc
4147561 atcggggagt tggcggcaat cgcgatcatc gtcggcccca aggcgtgcgc caggcggact
4147621 cgctcagccc atccttcctg cggtccggca tccagattga cctggatcgc ggctgtcgag
4147681 gtcatcatcg ccgcacccgg cactccgcta tggctggcgg cgaaaaactg ctccatggcc
4147741 cgatagcgtg cgcccggatt gacccgcacc ggcgaccgca gcgggtctgc acccaggaag
4147801 accaaaccca gcccggcatt ggcaagcgcc gaccgtagca ccgcctgatc gcgcgtcatg
4147861 gcaccgatgg ctgccagcac gccgtcggcg ggcggtccgg acagttcgac ggcaccaccg
4147921 ggctccacgc tgaccacgct gccgcccggc agcggactga gccattcgag aacctcggtg
4147981 atctcttccc agctgggccg gcgaaacgga tcggccgggt cgaagcagtg cgcctccatc
4148041 tccagaccga cgcgtcccaa cggaccatcg acgaggcagc cgtccgcgat gtattccgcg
4148101 gcggccgatg aatcggtgat ctcgacgtcg tccggggcag cgttatccag ctgcgaggcc
4148161 gcggcggtca tggcggcaag cgtcatatca cgatccctcc gggcccggcg catgcctaaa
4148221 acatgccctg cggaccgttg gttgcgcagc taccagaacg atagccgcca ccggtttatc
4148281 ctgccgaccg ccccgccgcg cgaatgaact ggccaactca gcccagtgtg ttctgcattg
4148341 ccccggccag cacgttgacc gcgggaccgg cgttgccgga ctgacagacc ttggcctgca
4148401 gcaatacgtt ttcgcgcagc ctggtttgaa caaagcatcg tcgatcggtg ccggcctctt
4148461 gtttggtcca ggcctcgtcg gtgccggtcg acggcccacc ggcgaacgac cacacctgcg
4148521 tcgtcccgtc gtccaggtgg atcgcggtgg tctgccccga gcagcccacg gttcggtcga
4148581 caacgcggtg aaacgcccgg tctgcggcat cgttgctggc gaatacccca accgcctgct
4148641 tgaccaggtg ggtttggtcg gtggcggacg tctgcgtggt agcgccgttg aacgacgcca
4148701 ggtcgggatc gtcgtacacc tcgggcagcc cgatgtccac ccagttgttg cacgccggta
4148761 gttcgaccca aaacgcctgg aacggcctgg tgaacaccgc ctcccacccc attggggcgc
4148821 cgacgatgtt gccgaccgac ccctttccga gcaccgcgta ggacacaacc ccgggctccg
4148881 acgggtgtgc gtcggcaaca ggtaccgcga accctgctat gacggctaga ccgatgctca
4148941 ccaccgcggc ggcgattcgc atggagctag accttggccg agatgtcgac gtcgatgttg
4149001 cccatgggtc acgatcatgc caacatggcc gaccaaacag aaggcccttt tcttgaacga
4149061 gtcaagaaaa ggggctggtg cgcccggccg ctaggggcgc gccggcgcgg tggtgggacc
4149121 cggaccagtc ggaccaacag ccgggccacc cgggcctcca gggaaaccgg ggcccatgcc
4149181 tgggggaggg ggtccgccgg ggaacccgaa cacccatccc atccctggac cgggggcaac
4149241 gggaccgacg gggcggaaca tgccgtggtg gtaatagcgg tggtaagggc atttcccctg
4149301 cccgagaacc aacgcgccag agaagaagat gactgcgacg gtgaaaacaa ttccggccac
4149361 gatcaccacc cacgctgcgg cccggtagag cctgggcggc ttttcctgct gcggcgatgg
4149421 cggcggtgaa gttgtggcgg cggacggcgg tggcgctgcg ggttggggtg tctcggtcat
4149481 cttttgaata tcgctcggcc ggcaaccacc gtaaagggtt gcggttacaa acgtgccatg
4149541 aactggtgca gcccggtgcc ttgggtggac accgggctgc tggttgtcgg ttacggagcg
4149601 ggtgtcgcgg gaggactgac ggacgacggc acctggccgg gcccgcccgg gcctgggccg
4149661 ggacgcactg ccgcgggccc accgtgcgga ctgcccggtc gcagcatcat cgccgggtgc
4149721 tggtggtgtt gccggtggtg gaagccgccg tgaccggcat gcttgccgag gatatagccg
4149781 gtgaagaaga tgaccgccac gatgaacacg gttccggcgg caatggctac ccacgccgcg
4149841 gctttgaaca ccttgggggt ctggtgaggc ggtggtgttg gggtttcaga tgtttcactc
4149901 atgtgtcgca tgatgccttg gcaaacagta acgcgactat gcgtccctta tgtagcagct
4149961 gtgagcgcgc gggctgggta tcggcccggg acaccaccat ggctgcgtct cggtgtcaga
4150021 gcaccagagc tacgggtctg accagggctt gaacgggttg accgcgaact gaatcacccg
4150081 gtacggccca ttctgccggg cccgagtgtc ccactggctg acgaagatcc gcagttcgtc
4150141 gatggtggac ccgggcgaga tgtagccgcc atacggttgt gcgagtcgat tgtcgtaggg
4150201 cggtggcagg ctttccgccg gctccggcca ctcgtcgtgg cgcaccaccg tggtcaccgg
4150261 ggcggcgccc agcgacgtcg ggtggtgtgc cacccgaacc tccatgttgc cggtgctggc
4150321 gttgaaatac gacagcaccg tctggccgtc gatctgacgg atgctcatct cgccgagctg
4150381 gtcgggccag agcggagtcg gcggcttgtt ccaaccgccg tcggggccgc ccgcccagcc
4150441 ctgccagcgg gaccggtcgg tgaacgattc cggggtggcc cgatacagca ccgccggctc
4150501 cccacgggtg aagctgtcgg ccacgatgta gacccaccca gttggcgaat cgggcgtggg
4150561 aaccgggtcg tagtatccgc tgatctgtgt ctgccggccg tcctggtagg cggcgttgcg
4150621 cctggacccc gacacggtct gccagccgcc gcgcgccgcc tcggcccgca ccaggcggga
4150681 attctgcggc tgcaggtcct tggtggtggt caccatcagg tagttgcggc ggttgatctg
4150741 caccacaccg gcgggcagct gtgagtctcc aggcggcgtg ggatcggcca gcagcggcgt
4150801 gccgacgccg gtgacaccgg tgtagcgcac cccggccgga tcgtcgatcg actcggtgtc
4150861 gacgtgcagc gcgaccggcg cataccagcc accgaacccg acaccctgac cggcgaagct
4150921 gtccccgcac acctgcagca gttgactggg gaattccacg aactcgcaca ggtcggtggc
4150981 accgatgccg tagtccccgg tgggggttcc ggtaccggcc gtcggaccga ttcgcagcac
4151041 ttgaccgggc gccagcggcg gcaggatggg ccggggcgcc ggcgccggcg gatcggcgcg
4151101 tgcataccaa acacattgcg ggacaaggaa agacactacc agcgagcacc gcacgaccca
4151161 ggcggagcac acccgcatat cacaagtcgg cggtcagcag ctcggcgatc tggatggtgt
4151221 tcagcgccgc ccccttgcgc aggttatccc ccgacacgaa cagcgccaga ccacgcccgt
4151281 cgggcacccc cgggtcgcgc cggatccggc cgaccagaga ttcgtcgaca ccggcggcgg
4151341 ccagcggcgt cggcacgtcg accagctgca cgcccgtagc accgtcgagc agctcgcgcg
4151401 cccgctccgg cgagagcggc tgcgcgaact cggcgttgat cgacaaagag tgtccggtga
4151461 acaccggaac ccgcacacag gtgccgctga ccaacaggtc ggggatgcca aggatcttgc
4151521 ggctctcgaa gcgcaacttt tgatcctcgt ctgtctcgcc ggagccgtcg tccaccaggg
4151581 atccggccag cggcaccacg ttgaacgcga tcggggcgac gtaggtgttc ggcggcggga
4151641 actcgagcgc gccgccgtca tacaccagct gctcggcccc accgatgacc gcacgcgcct
4151701 gctcggccag ctcggccacc ccggccaggc cgctaccgga caccgcctga tacgacgaga
4151761 ccaccaaccg caccagtcgg gcttcgtcgt gcagcacctt gagcaccggc atcgcggcca
4151821 tggtggtgca gttcgggttg gcgatgatgc ccttaggccg gcggtgcgcg tcgcgttcaa
4151881 agttcacctc ggacaccacc aacggcacgt cggggtcctt acgccacgcc gacgagttgt
4151941 cgatcaccgt gactccggcc gccgcaaagc ggggcgcctg caccttcgac atggccgagc
4152001 cggcggagaa caacgcgata tccagcccgc tcgggtcggc cgtctcggcg tcttccactt
4152061 cgatctcctg gccgcggaag gccagcttgc ggccctgcga tcgggccgac gcgaagaacc
4152121 gcaccgcgct cgccgggaaa tcccgctcgt cgagcaacgt gcgcatgacc tgacccacct
4152181 gaccggtggc ccccacgatc cctattgaca ggcccatcta ccgtcccgtc cccgcgtaca
4152241 ccgtggcctc ctcgtcgccg ccgagcccga acgcttcatg cagcgcgacc acggccttgt
4152301 ccagttcggt gtcgcggcac aacaccgaga tcctgatctc cgaggtggag atcagctcga
4152361 tgttgacccc caccgccgcc agcgcctcac agaacgtcgc ggtgaccccg gggtggctgc
4152421 gcatgccggc accgatcagc gataccttgc cgatgtggtc gtcgtacagc agctgtgaga
4152481 agccgatctc gtttctgagc gagtccagtt tttccacggc ggcgggcccg acgtcgcggg
4152541 agcaggtgaa ggtgatgtcg gtcttgccgt cctcgacctt ggagacgttc tgcagcacca
4152601 tgtcgatgtt gacgtcggcg tcggccaccg ccctaaacac cttggccgca tacccgggga
4152661 tgtcgggcag cccgacgatg gtcaccttgg cctcgctgcg gtcgtgcgcg actccggtca
4152721 ggatggggtc ttccatgggt acgtccttga tcgatccgac aacgacggtg cccggtctgt
4152781 ccgagtacga cgaccggacg tgcaccggaa tattatggcg gcgagcgtat tccacgcagc
4152841 gcagcatcag caccttggcg ccgcaggccg ccatctcgag catttcctcg aaggtcacgg
4152901 tgtcgagctt tcgggcgttg cgcacgatgc gcgggtcggc gctgaagatg ccgtccacgt
4152961 cggtgtagat ctcacagaca tcggcaccca gcgcggcggc catggcgacg gcggtggtgt
4153021 ccgagccgcc gcggcccaac gtcgtgacat ccttggtgtc ctggctgacc ccttggaatc
4153081 cggccaccaa aacgacccgc ccctcctcaa gggcggtttg cagccgcccc ggcgtgacgt
4153141 cgatgatctt ggcgttgccg tgggtgccgg tggtgatcac cccggcctgc gaaccggtga
4153201 acgaccgggc atgcgcgccg agcgactcga tggccatggc caccaacgca ttcgagatgc
4153261 gttcaccggc ggtaagcagc atgtccagct cccgaggcgg cggcgccggg cacacctgct
4153321 gagccagatc cagcaggtcg tcggtggtat cccccatggc agagacgacg acgacgacgt
4153381 cattgccttg cttcttggtg gcgacgatgc gttcggcgac gcggcgaatc cgttcggcgt
4153441 cggccaccga ggatccgccg tacttctgca cgacgagcgc cactgtttcc ctttccgggg
4153501 aagattggag acaggtccag aatagggggc gcgccggcct gcgctgactc tgcgtccacc
4153561 acgggaatgt gcgagtagcc cacacggtgg acgcagagtc aacgtgtaaa gtgcttcatg
4153621 tgcagcgggt gctcctcctc ggacgccgcg acggggtctg atccagaccg gcttcccgtc
4153681 gcgggacgtt cgcgatgcgc cggtctgagg ttccttctca ccatcccgga gcaactaccg
4153741 tgacaacttc tgaatcgccc gacgcctata ccgagtcgtt tggggcccac accatcgtga
4153801 aacccgccgg cccacctcgc gtcggtcagc cctcgtggaa tccgcagcga gcctcgtcga
4153861 tgccggtcaa ccgctaccgg ccgttcgccg aggaggtcga gcccatccgg ctgagaaacc
4153921 gcacgtggcc tgatcgcgtc atcgatcgtg cgccgctgtg gtgcgcggtc gacttacgcg
4153981 atggcaacca ggcgctgatc gacccgatga gcccggcccg caagcgccgc atgttcgacc
4154041 tgctggtccg gatgggctac aaggagattg aggtggggtt cccctcggcc agccagaccg
4154101 acttcgactt cgtcagagag atcatcgagc agggcgccat tcccgacgac gtcaccatcc
4154161 aggtgctcac ccaatgccgt cccgagctga tcgagcgcac cttccaggcg tgttcgggcg
4154221 caccccgggc catcgtgcac ttctacaact cgacgtcaat cctgcagcgc cgcgtggtct
4154281 ttcgcgccaa ccgggctgag gtgcaggcca tcgcgacaga tggggcgcgc aagtgcgtcg
4154341 agcaggccgc caaatacccg ggcacgcagt ggcgattcga gtactccccg gagtcctaca
4154401 ccggcaccga actggaatac gccaaacagg tgtgcgacgc cgtcggcgag gtcattgcgc
4154461 cgacgccgga gcgcccgatc atcttcaacc tgcccgccac ggtggagatg acgacgccca
4154521 atgtctacgc cgactcgatc gagtggatga gccgcaacct agccaaccgg gagtcggtca
4154581 tcctgagcct gcacccgcac aatgaccgcg gaaccgccgt cgccgcagcg gaattgggtt
4154641 tcgcggccgg ggctgatcgg atcgagggct gcctgttcgg caacggcgag cgcaccggca
4154701 acgtgtgcct ggtcacgctg ggactcaacc tgttctcccg aggtgtggac ccgcagatcg
4154761 acttctccaa tattgacgag atccggcgca cggtggagta ctgcaaccag ctgccggtgc
4154821 acgaacgtca cccctatggc ggcgacctgg tgtacaccgc gttctccggt agccaccagg
4154881 acgccatcaa caagggccta gacgcgatga agctggatgc ggatgccgcc gactgtgacg
4154941 tcgacgacat gctgtggcag gtgccgtatc tgcccatcga cccgcgcgat gtcgggcgca
4155001 cctacgaggc ggtgatccgg gtcaactcgc agtccggcaa gggcggcgtg gcctacatca
4155061 tgaagaccga ccacggcctt tccctgccgc ggcggctgca gatcgagttt tcccaggtaa
4155121 tccagaagat cgcagagggt acagcaggcg agggtggcga ggtctcgccc aaggagatgt
4155181 gggatgcgtt cgccgaggag tatctggccc cggtgcggcc tttggagcgg ataaggcaac
4155241 atgtggacgc tgccgacgac gacggcggca cgaccagcat cacggcgacc gtcaagatca
4155301 acggcgtgga gaccgagatc agcgggtccg gtaacggtcc gttggccgcg ttcgtccatg
4155361 cgctggccga tgtcgggttt gacgtggccg tgctggacta ctacgagcac gcgatgagcg
4155421 ccggcgacga cgctcaggcc gccgcgtatg tggaggcctc cgtgacgatc gcgagcccgg
4155481 cgcagccggg cgaagcgggt cggcacgcat cggaccccgt gacgatcgcg agcccggcgc
4155541 agccgggcga agcgggtcgg cacgcatcgg accccgtgac gagtaagacg gtgtggggtg
4155601 tcggtatcgc accgtcaatc accaccgcgt cgctgcgcgc cgtggtgtcg gcggtcaacc
4155661 gggcggcacg ctaggacggc gctgaactag ggtcggggtc cgcggcatga tttttcgcag
4155721 tgacgttccg ctcgccgttt cagaacaacg ctaactgctt ttcgacggga gcgacgtcgg
4155781 tgaagtcctc cacgctggcg cccccgacga cggcaccgat gcactccatg aatcgcgctt
4155841 caggcatcac cggaaccccc agctgcaggg cgtgatagcc cttgccgtgt tcgggggcgg
4155901 tcgcgttgca gaccaccagt gaggtatccc ggtctacgac gtcgctgtag gccagcccgg
4155961 cgtgcagaat ccgttcgacg agttcctcgt gggtccgttt tacctcggcc gccagcccca
4156021 cccgcatgcc ctggaccagc gggcggccct ggacataccg gcccgggttg aggtaggggc
4156081 aggccatccg ggctgccacg gccttcagcg gtcgcagctc gtcgtgagtc acccggccgt
4156141 tgggccaccg gcgccgtgtc accgggtgca ccggcagcca gacgtcgagt tcgcgcgcac
4156201 tctctagggc agctgccagt atcccggtca atacccggac gtcgtcgaat gcatcgtgcg
4156261 gccgttgctg gggcacaccc caatgcgcgg caagtgtctc cagccgcaga ttgtcgacgc
4156321 caagctgcag ccggcgggcc agctcgaccg tgcacatgac gaagtcaacc gggagttcgg
4156381 cctcggcgat ctcggcctcc gcagcgagaa acgcatagtc gaacgcgaca ttgtgcgcga
4156441 ccagagtgcg cccgcgcagc acgtcgacaa cctcaccggc gatatcggcg aactgtggct
4156501 ggccatcgag catggcggcg gtcaggccgt gcacgtgggt ggggcccggg tccaccttgg
4156561 gatttagcag gctgaccacg gattgctcta gtcggccggc ggcgtccagg ccgagcaccg
4156621 caaggctgat gatccgggcc tggcccggcc gaaagcccga ggtctcgacg tcgatgacgg
4156681 cccaaccccg atcctggtgg ctggctggcc gtccccaggt gtggctcaca agacgaggat
4156741 gacacgtccg agcgacatca cctggtcgct acgcatcgtg tcggcccgta aaacccggac
4156801 gcgggcgacc cgccgcaccc ggcgacaagc gccgagcttg cgatcgccct gaatccaacg
4156861 cgggcgaccc gccgcacccg gcgacaagcg ccgagcttgc gatcgccctg aatccaacgc
4156921 gggcgacccg ccgcacccgg cgacaagcgc cgagcttgcg atcgcccgta aactgcccgg
4156981 gtggtaacca cccgggcacg cctggcccta gccgccggcg cgggcgcacg ctgggcgtcg
4157041 cgggtcaccg gtcgcggcgc cggagcgatg atcggcggtc tggtcgccat gaccctggac
4157101 cgctcgatcc tgcgccaact cgggatgggc cggcgcaccg tcgtcgtcac cggcaccaac
4157161 ggcaagtcga ccaccacacg gatgaccgcg gccgcgctgg gcacgttggg agccgtggcc
4157221 accaacgccg agggcgccaa catggacgcc ggcctggtgg ccgcgctcgc cgctcaccgc
4157281 gacgccgagc tggcggtgct ggaagtcgac gagatgcacg taccgcacat ctccgatgcc
4157341 gtcgatcccg ccgtcgtcgt cttgctcaac ctctcccgag accagctgga ccgggtcggc
4157401 gagatcaacg tcatcgaacg cacactgcgg gccgggctgg cccggcaccc cgacgctgtc
4157461 gtggtcgcca actgcgacga cgtgctgatg acctcggccg cctacgacag ccccaacgtc
4157521 gtttgggtgg ctgccggcgg cgcgtggtca aacgattcgg tcagctgccc gcgcagcggc
4157581 gaggtcatcg ttcgcaaggc cccctctcag gaagaccact ggtactccac cggcgccgac
4157641 ttcaagcggc ccgccccgca ctggtggttc gacgacgcca cgctgtatgg gcccgacggg
4157701 ctggcgctgc cgatgcggct ggcactgcca ggctcggtga atcgcggcaa cgccgcccaa
4157761 gccgtggccg ccgcagtcgc cctcggcgcc gatccggctg tggccgtcgc cgccgtctgc
4157821 caggtcgacg aggtcgccgg acgctaccgg accgttcgta tcggcgcgca ccaagcccgg
4157881 atcctgctgg ccaaaaaccc ggccggctgg caggaagcgc tggcgatggt cgacaagcat
4157941 gcagacgggg tggtcatcgc ggtcaacggg cgggttcctg acggcgagga cctgtcctgg
4158001 ttgtgggacg tgcgcttcga gcacttcgag aagacccgag tggtagccgc tggggagcgc
4158061 ggcaccgatt tggcggttcg cctcggatat gcaggcgtcg agcacaccct ggtgcacgac
4158121 accgtggccg ccatcgcctc atgcccaccc gggcgggtgg aggtcgtcgc caactacacc
4158181 gcgttcctgc agctgcaacg agcattggcg cgtcgtggct gattctgtgg tgcggatcgg
4158241 gctcgtgctg cccgacgtga tgggcaccta cggcgacggc ggcaacgccg tggtgctacg
4158301 acagcggctg ctgctgcgcg gcatcgccgc cgagatcgtc gagatcacgc tggccgatcc
4158361 agtgccggat tcgctggacc tctacacgct gggcggagcg gaggactacg cgcagcggct
4158421 ggccacccgg cacctacgtc gatatccggg cctgcaacgc gcggcgggcc ggggtgctcc
4158481 agtattggcg atctgcgcgg ccatccaggt gcttgggcac tggtacgaga cgtcgtcggg
4158541 agaccgggtc gacggcgtgg ggttgctgga tgtgaccacg tcaccgcagg atgcgcgcac
4158601 catcggcgag ttggtcagca agccgttgct ggccggtttg acccaaccct tgaccggttt
4158661 tgagaaccac cgcggcggca ccgtcctcgg gcccggaacg tcgcccttgg gcgcggtggt
4158721 caagggagcc ggcaaccggg ccggcgacgg ttttgatggc gcggttgcgg gcagcgtggt
4158781 cgcgacctac atgcacgggc cgtgcctggc ccgcaacccg gagcttgccg acctgctgct
4158841 gagcaaggtg gttggtgagc tggcgccgct ggatttgccc gaggtggacc tgctgcgccg
4158901 cgaacggcta tccgcgcgtt aggtggggcg ttagggccgc catcccctgg ccagcagagc
4158961 ggcacgcacg cggttcacca cgtcgtcggg gttgtcctcg gcgatcacgc gaatgacgat
4159021 ccagcccaac tcggccagct tgcggagccg ccgctggtct ttcacgtagc gaccgcggtc
4159081 gctgcgatgc tgatcaccgt cgtactcggc ggccaccatg tatttctccc agcccatgtc
4159141 gagcacgcca acgttgcgcc agcggtggac caccggaatt tgcgtcgtgg ggactggcag
4159201 gccggcgtcg atcaacaaca gccgcagcca ggtctccttg ggcgacgcgg cgccgccatc
4159261 aacaaggggc agcacgtcac gcaaccggcg gacacctcgg gcgcccgcgt gacgcttggc
4159321 caatagaagc acgtcgtcgc gggaaaacgg ggtggcacgc atgagggcat cgagacgagc
4159381 cacggcttcg ccgcgggaca gatggcggcc gaggtcgtat gccgtccgcg ccagtgtggt
4159441 gaccggcagg cccaccaccc tggtgatctc gtcgtcgcac aaggtctcac gacgtatgac
4159501 aagaccgtgc tgcgggcggg tagtgggaga aatcagctcg atggccacgt cgacgtccac
4159561 ccactgagca ccatgcagcg cagaggccgc attaccagct atgacgccat ggcgcctcgt
4159621 ggctagccag gcgccaaccg tgcgatccca aagtgtgggc actgagcgcc tcgagacgta
4159681 cacaccgcgg aacatcggct gataccaacg ttgcagctcg tgcctggtca ggcgaccagc
4159741 ggtgatggcc tcgctgccga tgaagacgtc acccatgacg gacatgctgg cactccgcac
4159801 cgacatccgt gagatcaaca ttttgcaggc aaggtgcgag tagcggcctg cagaacgttg
4159861 atctcggcga aagtcggatg tcggcgaatc aggcgagcac gcggcggccg gcgagcgctc
4159921 ggcccagggt gagctcgtcg gcgaattcca ggtcaccgcc catcggcagc ccggacgcga
4159981 tccgtgtgac ggtcaggccg gggatgtcgc gcagcattcg caccaggtag gtggccgtcg
4160041 cctcgccctc ggtgttgggg tcggtggcga tgatgacctc ggtgacgtcg acgtcgtcga
4160101 cccgttcccc gatgcggctc agcagttcgc ggatccgcag ctgatccggc ccaattccgg
4160161 acagcgggtc aagcgccccg cccaggacgt gatagcgacc ccggaactcg cgggtgcgct
4160221 cgacggcctg gatgtctttg ggttcctcga caatgcacac cacggacgca tcgcgacgga
4160281 tatcagagca gattctgcaa cgctcgttgt cagagacatt cccacacacc gcgcagaatc
4160341 gcacgccgtc ccgaaccttc gccagcacac cggtcagccg gtcgatgtcc gacggttcta
4160401 ccgacaacag gtggaaggcg attcgctgcg cactcttggg tccgatcccc ggcaacttgc
4160461 cgagttcgtc aatcaggtcc tggacgggtc cctcaaacat gtcggtgcag gtcagatccc
4160521 tggtacaggt ggtgcgcccg gcgcacccgg catacccggc atacccggca tacctggcgc
4160581 tcccggcggc gcagccggtg gtgccggcgg gcgcatcgcg ccggccaatg cacccagccg
4160641 ttcctgcgcc atcttcgtca cctgctggga cgcgtcgcgc atcgcaccga cgatcaggtc
4160701 ctgcaaggtc tcgatgtcgt cgggatcgac gaccttgggg tcgatcgtca cgccgatcac
4160761 ctccccgctg cctttgacga cgaccttgac caggccccca ccggcttgac cgtgcacctc
4160821 agagttcgcc agctgttgct gggcctccag gagcttttgc tgcatctgct gcgcctgagc
4160881 gagcagcgcc gacatgtcgc ctccgggttg catgacagtc ccctagcatc ttggtctcga
4160941 gttggtttcg cctgtggttg tcgggcgatt cggaacattc agcctagacc gcgccgcgtt
4161001 acctttgcgc cgtggaccta cgagttggcc cgcgtgtcgg gttcgccatg atagtcgggg
4161061 tactcgtcgc agcagcgacg ccgatcatct cgtccgcgag cgcaaccccc gccaacatcg
4161121 ccggcatggt cgtcttcatc gaccccggac acaacggagc caacgacgca tcgatcggcc
4161181 gccaggtacc caccggtcgc ggcggcacca agaactgcca ggccagcgga acgtcaacca
4161241 acagcggcta cccggagcac accttcacct gggaaaccgg gctgcggctg cgggccgcgt
4161301 tgaacgcatt gggggttcgg accgccctgt cacgtggcaa cgacaacgcg ctcggaccgt
4161361 gtgtcgatga gcgcgccaat atggccaacg cgttgcgccc caacgcgatc gtgagcctgc
4161421 acgccgacgg cggaccggcg tctggccgcg gattccacgt caactactcg gccccgccgc
4161481 tcaacgcgat acaggccggt ccctcggttc agttcgctcg aatcatgcgc gaccagctgc
4161541 aggcctcggg cattccgaag gcgaactaca tcggccagga cggcctgtac ggacgttcgg
4161601 acttggccgg cctgaaccta gcccaatatc cgtcgatcct ggtcgagttg ggcaacatga
4161661 agaaccccgc ggactcggcg ctgatggagt ccgccgaggg caggcaaaaa tacgccaacg
4161721 ccctggttcg cggcgtcgcc ggcttcctgg ccacccaggg ccaggcgcgt tagccccgca
4161781 cacaggcggc acccccaccg cgcccgcatc gtcgtcaggc gtcaccctcg agttcggtct
4161841 tgaggttgga cagcacctcg gcctggatct tcttcagccc tagcggcgca aaggtcttct
4161901 cgaagaaacc cttgaccccg cccgcgccgg tccaggtggt cttcaccgtg acgctggaac
4161961 cgggtccggc gggagcgacc gtccagttgg tgaccatgga cgaattcatg tccttctcga
4162021 tgacggtgtg cccggcaacg tccacgttca cctgcacatc gcgaacacgc gactgcgtcg
4162081 cctgcagccg ccacttggcg actgtgcccc gccccttgcc gccctcgagc acctggtact
4162141 cgctgtagtg cggggacagg attttaggac ggacggtctc atagtcggcc agcgcgtcga
4162201 gtgtggccgt gggctcagca ttgatcaaga tcgtgctggc tgcgctcacc tgtcccatca
4162261 gggccggact ccttcgtttg tgattgctgc accgcccgca cccggatgca ggggcagttg
4162321 tcgaggacta gggtatatac ggtgcctgtc cctggatctg cacagtcggc ttacgcctgc
4162381 ggcgtcgagc ggttgctggc gagctatcga tccatccccg cgactgcatc catccggctt
4162441 gccaagccca cctcaaatct gttccgcgcc cgcgtcaaac acgatgcacg cggcctggac
4162501 gcatcgggac tgaccggtgt catcggtatc gatcccgagg cccgcaccgc cgacgtggcc
4162561 ggcatgtgca catacgagga cctaatcgcc gcgacactgc actacggtct gtcaccattg
4162621 gtggttccgc agctgaggac gatcacattg ggcggagcgg tcaccggctt gggtatcgag
4162681 tcggcgtcgt tccgcaacgg cctgccccac gagtcggtgc tggagatgga tatcctcacc
4162741 ggcgcaggag aacttctcac cgtctcgccc ggacagcact ccgacttgta ccgtgcattc
4162801 cctaactcgt atgggacact gggctattca acccggcttc gaatccagct ggagccggtc
4162861 cggccgtttg tcgcgctgcg gcacatccga tttagctcgt tgacggcgat ggtggccgca
4162921 atggagcgca tcatcgacac cggcggactg gacggcgaat cggtggacta tctcgacggg
4162981 gtggttttca gcgctgacga aagctacctg tgcatcggca tgcagacgag cgtaccgggc
4163041 ccggtcagcg actacaccgg acaagacatc tactaccggt cgatccaaca cgaggcgggg
4163101 atcaaggaag accggttgac catccacgat tacttctggc gctgggacac cgattggttc
4163161 tggtgctcac gatcgtttgg tgcccaaaac ccgcggctgc gccgctggtg gccgcggcgc
4163221 taccggcgta gcagtgtcta ctggaggttg atggcgctcg atcagcgctt cgggatcgcc
4163281 gaccggttcg agaacagcag gggtcgtccc gcgcgtgaac gggtggtgca ggatatcgaa
4163341 gtgccgatcg aacggacctg cgagtttctg gagtggttcg gggaaaacgt gcccatttcg
4163401 ccaatctggt tgtgcccgtt gcggctacgc gatcacgccg gctggccgct gtacccgatc
4163461 cggcctgacc gtagctatgt caacatcggg ttctggtcgt cggtgccggt tggcgccacc
4163521 gagggcgcca ccaaccgcaa gatcgagaac aaggtgagtg cgctcgacgg gcacaagtcg
4163581 ctctactccg actccttcta tacccgcgag gagttcgacg agctctacgg cggcgagact
4163641 tacaacactg tgaagaaagc ctacgatccc gattcgcgtc tcctcgatct ttacgcaaag
4163701 gcggtgcaac gacgatgaca acgggcagac tcagcatggc cgagatcctg gagatcttca
4163761 ccgcgaccgg gcaacacccg ctgaagttca ccgcgtatga cggcagcacc gcgggacaag
4163821 acgacgccac actgggcctg gatcttcgga cgccccgcgg cgccacctac ttagctaccg
4163881 ctcccggcga actcggcctg gcccgcgctt atgtgtcggg tgacctacag gcacacggag
4163941 tacatcccgg cgatccgtac gaactgctca aaacgctgac cgaaagggtc gacttcaaac
4164001 ggccgtcggc gcgggtgctg gctaatgtgg tgcgctcgat cggcgttgag cacatactgc
4164061 ccatcgcgcc gccaccccag gaggcgcgac cccggtggcg tcgaatggct aatggcttgc
4164121 tgcacagcaa gacccgtgac gccgaggcta tccatcacca ctacgacgtc tccaacaact
4164181 tctacgagtg ggtgctcggg ccatcgatga cctacacgtg cgcggtgttt ccgaacgctg
4164241 aggcttcgct ggagcaggcc caagagaaca aataccgact cattttcgaa aagctacggc
4164301 tagagccggg tgaccggcta ctcgacgtcg gctgcggctg gggcggcatg gtgcgctacg
4164361 ccgcccgacg cggtgtccgg gtgatcggcg ccacgctctc ggccgagcag gccaagtggg
4164421 gccagaaagc agtcgaggac gagggattga gcgacctcgc gcaggtgcgg cattccgact
4164481 accgcgacgt agccgagacc ggtttcgacg ccgtttcttc gatcgggcta accgagcaca
4164541 tcggcgtcaa gaattacccg ttctacttcg ggtttctcaa gtcgaagttg cgcaccggcg
4164601 gcttgctgct caatcactgc atcacccgcc acgacaacag gtcgacgtcc tttgccggcg
4164661 ggttcaccga ccgttacgtt ttccccgacg gggagctgac gggctcggga cgtattacca
4164721 ccgagatcca gcaggtcggc ttggaagtgc tgcacgagga gaacttccgc catcactacg
4164781 cgatgacgct gcgcgactgg tgcggcaacc tcgtcgaaca ctgggacgac gcggtcgccg
4164841 aggtcggtct gccgaccgcc aaggtgtggg gcctgtacat ggcggcttcg cgggtggcct
4164901 tcgaacgaaa caacctgcag ctacatcacg tattggcgac caaggtggac ccccggggcg
4164961 acgacagctt gccactgcgg ccctggtggc agccctaggc gttgtctatc cggcgcgcgc
4165021 ccagctcgtt ctgcagcagc tcgagtgcaa cctcttccgg gtcgcgacgc ggcgacgggt
4165081 cgccacggcc ggcttcggcg agcatgtgct cctcttcgtc gcgctgagtg gaattcgctg
4165141 tgggggcagg gtttacggcc ttggcggtcg ccacgttcgc tcccccgccg acgggtgatg
4165201 ccgccgcagc cggttcaccg gtctcacacc gcacccgcca gttgactccc agcgcgtctt
4165261 taagcgcctc ggcgaggaca tcggcgttgc gctgttcgga cagccgccgc gccagcggcg
4165321 ccgattcgtg ggtcagcacc agcgtgttgt cctctagcgc acggacggtg gcacccgcca
4165381 gcatcacctc ggtggtacgg ctgcgcaggc gcaccttgtc gcgcaccgtc ggccacatgg
4165441 accgaaccgc ggccacggtg ggttcgctcg aggccggtgt gggggccagc accggtctcg
4165501 gttcacgcgc gggctggtgt ttcggctcgg cagccgcagc cgacgggcgt ggtacggctt
4165561 gcggcgccgg gatcgacatg tccaaccggg tctcgatccg ttcgacccgc tgcaacagtg
4165621 ccgattcggc gtcgctcgcc gagggcagca gcagtcgcgc gcaaaccact tccagcagca
4165681 gacgcggcgc ggtcgcaccg cgcatctcgc ctagcccggc ctgcaccacc tcggcatatc
4165741 gggtcagggt cgcccgcccg atccgggcgg cttgctcgcg catccgatcc agcgcgtctt
4165801 cgggcgcatc caccaccccg cgagatgccg cgtcgggaac cgattgcagc acaatcaggt
4165861 cgcggaatcg ctccagcaga tcggtagcga aacgccgagg gtcatgtccg ccatcgatca
4165921 ccgattcgat cgccccgaac aatgcggccg catcgcaagc ggccagtgcg tcgaccgcgt
4165981 cgtcgatcag ggcgacgtcg gtgacaccca gcagccccag cgcccgggtg taggtcacgt
4166041 gggtgtccgc ggccccagcc agcaattggt ccagcaccga gagcgtatcc cgtggggaac
4166101 ctccgccggc ccggatcacc aacgggtaca ccgcatcgtc gacgacgacg ccctcctgct
4166161 cgcagatccg cgcgagcaac gcccgcatag tgcgcggcgg cagcagccgg aacgggtagt
4166221 gatgagtgcg cgaccgaatc gtcggcagta ccttctccgg ttcggtggtg gcgaatatga
4166281 agatcaggtg ttcgggcggt tcctccacga tcttgagcag cgcgttgaat cccgcggtgg
4166341 tcaccatgtg cgcctcgtcg acgataaata cccggtaccg tgactggacc ggcgcataga
4166401 acgcgcggtc ccgcagctcg cgggtgtcgt ccacgccgcc gtggctggcg gcatccagct
4166461 ctaccacgtc gatgctgccg ggggcgttgg gcgccaacga aacgcaggat tcgcagaccc
4166521 cgcacgggtt ggcggtaggg ccctgcgcac agttcaacga ccgcgccagg atacgcgctg
4166581 acgacgtctt tccgcagcca cgcggcccag agaacaggta cgcgtggttg atccggccgg
4166641 catccagcgc caccgacagc ggcgcggtga cgtgctcctg ccccaccacc tccgcgaagc
4166701 ttgccggtcg gtacttgcgg tagagagcca cgtcagcagg ctaccgaccc taggcgacga
4166761 gtgtgttcgc agcgtcgaat gtgaacgttc ggcgtgattt cggcgcgcgg gttcccgctc
4166821 tcagcgcacg ttcggcgccg aggaggctag tccctggtta agcaatgtct cggtcgccgc
4166881 cagcagcgcg caggtcgcca acccgtcaac cgcgttgcgc aggtccggta ccgacggaaa
4166941 cgacggcgcg atccggatgt tcttgtcgtc cggatccttt cgatacggga acgacgcccc
4167001 cgcctcggtc accgcgatac caacgtcctt agccaaggct acggtccggc gcgcggtccc
4167061 gggcaacacg tcgaggctga tgaagtagcc acccttgggc tcggtccagg aggcgatctt
4167121 ggactcgctt agccgctgat ccagaacttc ggccaccaac gcgaatttcg gcgccagtat
4167181 ctgctggtga cgcaacatgt gtagacgtac cccatcggcg tcgccgaaga agcgtagatg
4167241 ccgcagctgg ttgaccttgt ccgggccgat cgacttcttc ccggcgtact gcagatacca
4167301 ggcgatgttg cctaacgatc caccgaagaa gctgacaccg ccgccggcga aggtgatctt
4167361 cgaggtggac gcgaagacgt aggggcggtt ggggttgccg gccttggcgg ccagcccgag
4167421 cacgtcgacc tggcgcggga aatccagcgt cagggtatgc accgcatacg cgttgtccca
4167481 gaacaagcgg aagtcaggtg ccgccgtccg catctggacg agtcggcgaa ccgtttccca
4167541 ggaataggtg acgcccgaag ggttgccgaa gaccggtacc gtccacatcc ccttgatggc
4167601 tgggtcgacg gcaaccagtt cttcgatcag atcgacgtcg ggcccatcct gcagcatggg
4167661 tatcgggatc atctcgatgc ccatggtctc ggtgatggca aagtgccggt catagccggg
4167721 gaccgggcac aggaatttga tgccgtcctg ctcctgaatc caaggccgcg gcgagtccac
4167781 gccgccatac aacatggaga aggcgacgat gtcgtgcatc aattccaggc tggagttgtt
4167841 gcccgcgatc aggttgggca ctgcgatgcc gagcagttcg gcgaagatag cccgcaggcc
4167901 cggcaggccg tgctggccac catagttgcg ggtgtcggtg ccctccgggt cgcggtagtc
4167961 gtctccgggc aagctcagca gctggttcga caggtcgagc tgctctgcgg atggtttgcc
4168021 gcgggtgaga tccagagcca gcttcatgcc ctgaagcgcc gcataatcct gctgatggcg
4168081 tgcgtgtagt gccgctagct cttgggggct aagagagtcg aacgacaccg tgggcccttt
4168141 cgccgagtcg aaaaccgtgg gtataccgag gtccagtcag tgccccggct gaaggggacc
4168201 ccgcgcaccc gacagagccc gttgaccctt gctgccttcc agccctgggg gagttcacag
4168261 gatagacgcc gcgcggggtc caccgtgagt ctaatacctg ggctggaacg cccgggacgg
4168321 actcagcggg ctaccatatg ctgcggagga ttcgcctagt ggcctatggc gctcgcctgg
4168381 aacgcgggtt gggttaacag ccctcgcggg ttcaaatccc gcatcctccg ccaggtggtc
4168441 cgcagcgcgg acgggaacgc ggacgggaac gcggacggga acaatgtggg ctggtcggct
4168501 tctcaccggc tcggttcacc agcctaagga ggggtatggg gcgcaaggtc gccgtgctgt
4168561 ggcacgcgtc gttttcgatt ggcgccggcg tcctctactt ctatttcgta ttgccccgtt
4168621 ggcctgagct gatgggtgac accggacact cgctggggac tgggctccgg attgccacgg
4168681 gcgcgttggt cggtctggcc gcactgccgg tggtattcac tttgctgcgc acccgcaagc
4168741 cggagctggg caccccgcag ctggcgctgt caatgcgaat ctggtcgatc atggctcacg
4168801 tgctggccgg cgcgctgatc gtcggcaccg cgattagcga ggtctggctc agcctggatg
4168861 ccgccgggca gtggttgttc gggatctacg gagctgccgc cgcgatcgcg gtgctcgggt
4168921 tcttcgggtt ctacctgtcg tttgtcgccg agctgccgcc gccaccgccg aagccgctca
4168981 agccgaagaa acccaagcag cgacgccttc gccgcaagaa gacggccaag ggcgacgagg
4169041 ctgagccgga agccgccgaa gaagccgaga acacggagct ggcggcgcag gaggacgagg
4169101 aggccgtcga agctcccccg gaaagcatag aaagcccggg aggtgaaccc gagtcggcga
4169161 cccgggaagc tccggcagca gagaccgcca ccgccgagga gccccggggc gggttacgga
4169221 atcgccgccc caccggcaaa acctcacatc gacgccggcg cactcgcagc ggtgtccagg
4169281 tcgccaaggt cgacgaatag ccgcggtcag gtgctgtagc ggcggctgtg aaccctgcga
4169341 cgcaatgtcg gcgtgtcacg ttgtcggatt cactgtcgcc ggctagcgct ttcccgtcag
4169401 aagacgagaa gcctccccga tctccaacta gcatcgagat cgggcttgcg aaggttgggt
4169461 tgcaaaatgg atgtcatcag atgggctcgc cggcttgcgg tggtggcggg cacagcagcg
4169521 gcagtgacca ctcctgggct actgagtgcg cacgttccga tggtctccgc cgaaccgtgt
4169581 cccgacgtcg aggtggtgtt tgcccgtggc accggggagc cacctggtat tggcagcgtc
4169641 ggaggactgt tcgtcgacgc actgcgtttc ccaggttggc gccaagtcac tcggggtcta
4169701 cgccgttaac taccccgcca gtaacgactt tgccagcagc gacttcccta agacggtcat
4169761 cgacggaatt cgcgacgcgg gctctcatat ccagtcaatg gcgatgagct gtccccagac
4169821 caggcaagtg ctcggtggat actcccaagg tgcggccgtg gccggttatg tcacctcggc
4169881 tgtggtaccg ccggctgtac ccgtgcaggc ggtaccggca ccgatggccc cggaggtagc
4169941 aaaccacgtc gccgcggtca ctctgttcgg cgcaccgtcg gctcaattcc tgggccagta
4170001 cggcgcgccg ccgatagcca tcggtcccct gtaccagccg aaaacgcttc agttgtgtgc
4170061 cgatggcgac tcgatttgtg gcgacggcaa cagcccggtc gcgcatggcc tgtacgcggt
4170121 gaacggcatg gtaggccagg gcgcgaattt cgccgccagc cgcctgtagc cagaactgcg
4170181 ctgccacccc agcgagagct gggcggtgat ccaatgcaga atgccaccat gcgcgttctg
4170241 gtcaccggcg gtacgggatt tgtgggcggg tggactgcca aagccatcgc tgacgcgggc
4170301 cactccgtcc ggttcctggt gcgaaatccc gcacggctga agacgtctgt cgcgaaactg
4170361 ggcgtcgacg tgtcggactt tgcggttgca gacatatccg accgcgattc ggtacgggag
4170421 gcgttgaacg gatgcgacgc cgtcgtgcac agcgccgcgc tggtggcaac cgacccgcgt
4170481 gagacttcgc ggatgctgag tacgaacatg gcgggcgccc aaaatgttct cggtcaagcc
4170541 gtcgagctcg gaatggatcc gatcgtgcat gtgtcgagct tcacggcgct gtttcgtccc
4170601 aacttggcga cgctgagcgc tgatctgccg gttgccggtg ggacggatgg atacggacaa
4170661 tccaaagcgc agatcgaaat ctatgcgcgc ggtcttcagg acgccggcgc accggtgaac
4170721 atcacttatc ctggcatggt cctcggcccg ccggtgggcg atcaattcgg tgaagccggg
4170781 gagggtgtcc ggtccgcatt gtggatgcat gtcattcccg ggcgcggcgc ggcgtggttg
4170841 atcgtcgacg tccgagatgt ggcggcactg cacgcggcgt tgttggaatc cgggcgtggg
4170901 ccgcgccgct acactgcggg aggtcatcgg attccggtgc ccgagctcgc gaaaattctg
4170961 ggcgggtcgc cggcaccacg atgctggccg tcccggtgcc cgattccgcg ctgcgtgtcg
4171021 cgggatcggt gctggatcaa gccgggccct atctgccttt caatactccg ttcaccgcgg
4171081 caggtatgca gtactacaca cagatgccgg agtccgacga ttcgccgagc gaaaaagaac
4171141 taggcatcac ctaccgcgat ccgcgcgaca ccgtggccga caccgtcacg gccctgcgcg
4171201 gcctgggcag ctaactgccg tcgggaggtt ccgccggttc cgcgtcgggg cgcgaattct
4171261 tcaaccactg cttcagccgg agcagttcgt tgacgacgat gccgacgccc aggaggatga
4171321 ccagcgtcac cacaatagcg gtggccacgt agtccatggt gacagccccg ccacggcgca
4171381 cgttcaggcc gcttgctgtc ggatcgagag gacctacgcg atgaaggcgg tgacctgcac
4171441 caacgcaaag ctcgaggtag tcgaccggcc gtccccggcg ccggccaagg gtcaactgtt
4171501 gctcgatgtg ctgcggtgcg gtatctgcgg atcggacctg catgcccgct tgcactgtga
4171561 tgaactggcc gacgtgatgg ccgaatctgg ctaccacgcc ttcatgcgat cgaatcagca
4171621 ggtggtgttc ggacacgagt tctgtggcga ggtggtcgat tacggtcccg gcacccgcag
4171681 gacccctagg cgcggcaccc cggtcgtcgc catgccgctg ctgcggcgtg gcaacaaaga
4171741 ggtgcacggg atcgggcttt cgacaatggc gccgggcgcc tacgccgagc ggctcgtcgt
4171801 cgagcagtcg ctgacgtttc ctgtcccgaa cgggctggcg cccgagatag ccgcgctgac
4171861 cgagcccatg gccgtcggat ggcacgccgt ccggcgcggc gaggtgggca agggcgacgt
4171921 cgcgatcgtg atcgggtgcg gtccgatcgg cctcgcggtg atctgcatgc tgaagtcgcg
4171981 cggggtacac acggtgatcg caagcgactt ttcacccggc cgtcgtgccc tcgcaaccgc
4172041 ctgtggcgct gattccgtag tcgatcccgt acaggactca ccgtatgcgg tagccgccgg
4172101 ccttggacag ggaaacagac acctgcaaag catcctcgac gcgttcgacc tcgcagtcgg
4172161 cacggtcgaa agactgcagc ggctgcggct gccgtggtgg cacctttggc gggctgccga
4172221 agcagctggc gccgcaacgc caaagcgtcc agtcatcttc gaatgtgttg gcgttccggg
4172281 aattatcgat ggcatcatcg ccagcgcacc gctgttctcg cgcgtcgtcg tggtcggcgt
4172341 ctgcatgggc tcagaccaca tccggccggc gatggcgatc aacaaagaga tcaacctgcg
4172401 gttcgtcctc ggctacacac cgttagagtt ccgcgacacg ttgcacatgc tggccgacgg
4172461 caaggtcaac gccgcgccgc tgatcaccgg gacggtcggt ttacccggcg tggcggcagc
4172521 attcgatgcg ctcggcgatc ccgaggcgca cgcaaaaatc atgatcgacc ccaagagcaa
4172581 cgccgcgagt ccccaaccat tccgcgtgga gtgaatgatg cgggatagcc gcacggcgtt
4172641 ggatccaccc gggacgacag cttgaattca ggcggcctct gctttaaagc gcacactacc
4172701 gcgcctgctg cggcatggat ccaaatatcc gccaaagtac gtatggacat ccgatagccc
4172761 ggcgcaccta cgacccgccg cgcagacaca tttacgcgtt cgcaccgatg gctgcggacc
4172821 cagcaaatgg cagagttaga gcgtcggccg tgtcttgagt caatgcttcc aggccggcac
4172881 cttttctccc gtggaccgca tgtgcccacg gtcgcgtcag taccgcccga atcattcctt
4172941 gaggcctatt gcagatgaaa ccgtcgcctg ccgataccca cgtcgtgatt gccggtgctg
4173001 gcatcgcggg attggctgcc gccatgatcc tggccgaagc cggggtgcga gtcacattgt
4173061 gcgaagctgc atccgaagct gggggcaagg ccaagagttt acgtctcgcg gacggccacc
4173121 cgaccgagca cagtttgcgg gtttacaccg atacttacca aaccctgctg acgctgttct
4173181 cgcgtatacc caccgaacat gacaggaccg tgctagacaa cctggtcggc gtcagcatgg
4173241 tttcggctac cgcgcaaggc gtgattggcc gaatcgctgc gccagttgcc ttgcaacgcc
4173301 ggcggccaac cttcgcgcgg atcataggca aggtagtcga accgccgcgg caacttgtcc
4173361 ggatcttgtt gcgcggccca atggtaatcg ttggtctggc ccaacgaggt gtgccggcca
4173421 ccgacgtcct ccattacctc tacgcccatc tacggctgct gtggatgtgc cgagagcgac
4173481 tcttggcgga gctgggcgat atctcgtatg cggattatct gcagctcggc tgcaagtctg
4173541 cccaggcgca ggaattcttt tctgctgtgc cgcgcattta cgtcgcggcg cgcaccagtg
4173601 ccgaagcggc ggccattgcg cccatcgttc tcaaggggct gtttcgcctg aaaagtaatt
4173661 gtccatcagc cctcaacgac gcaaagctgc ccgcgatcat gatgatggat ggaccgacca
4173721 gcgagcgcat ggtcgatccc tggattcgcc acctgacaag gctcggcgtg gacatccact
4173781 tcaacacgcg tgtcggcgat ctcgagttcg acgacggtcg cgtcaccgca ttgatatcgt
4173841 ccgatggccg ccggtttgcc tgcgactatg ccctgctcgc ggtgccctat ctgacgctgc
4173901 gagagctggc caaatcagct catgtcaagc gatatctccc tcagctcaca cagcagcacg
4173961 cccttgcgct tgaggcatcg aacggaatcc agtgttttct gcgcgacctc cctgcgacgt
4174021 ggcctccgtt catccgccct ggagtcgtca ctacgcatct gcaaagccag tggtcgctgg
4174081 tctgcgttct gcagggagaa ggtttctgga aaaacgtccg cctgccggaa ggaacccgct
4174141 acgttctgtc aataacctgg agtgatgtgg aaacgcccgg acctgttttt gatcggccat
4174201 tgagtgaatg tacgccagat gagatcttga ccgagtgcct gacgcagtgc ggcctcgata
4174261 aatcgaacgt cttgggctgg cggatcgatc acgagctgaa gcacttagac gaggccgaat
4174321 acgaaaaggt ggcgagcgag ctgcctcctc atcttgtctc ggcgcctgcg cgcgggcagc
4174381 gcatggtgaa tttctcgccg cttaccgtat tgatgccggg cgcgcgccac cgctccccgg
4174441 gtatttgcac ctcagtgcct aaccttttgc tagccggtga ggtgatctat tcacccgacc
4174501 tgaccttgtt tgttccgacc atggagaagg cggcatgctc cggctatctg gccgcccgcc
4174561 aaatcatgaa catggttgct tcgcacgccg caccgctgcg gatcgacttc cgggatcccg
4174621 ccccatttgc ggttctgcgg cgggtggacc gatggttttg gagccgccgc cgacgaccgc
4174681 cagaccggtc gacatttgca accccaccaa ccgccatgcc ggcgccgagc cacctgaccg
4174741 acgtggatcg ctctgcaagt tagccgccgg taacccacca agcctcgtca cgctacaagt
4174801 ccaccgttga accgacggcg ttgacgcgtc acatatccct gatccttcaa gaacgtggag
4174861 tttcccttga ctgtgcacac cgtcgccacc aacaatgctg cgcccgtcat agccgccggt
4174921 cccgtcggcc ctagcagacg acgccgtcgc gtgcacgccc cacttacgcg acgccgccaa
4174981 ccctcctcct cggcggtgct gctggtggcg gctttcggcg ccttcctcgc tttccttgac
4175041 tccacgatcg tcaacgtcgc gttccccgat atccagcggc acttccacag cgacatcagt
4175101 gacctgtcct ggatgctcaa cgcctacaac attgttttcg cggcgttcct ggtggccgcc
4175161 ggcaggctgg ccgacctgat ggggcgcaag cgggtgttca tcttgggggt ggcgttgttc
4175221 accgtcgcgt ccgggctgtg cgcgatcgcc gaaagcgtcg gggaactggt tgcgttccgt
4175281 gtgctgcaag gcatcggcgc agcggttctg gtaccggctt cgctggggct ggtcgtcgag
4175341 gccttcccgg ccgagcggcg cgcgcacggg gtcaacctgt ggggtgcggc gggggccatc
4175401 gccgcgggcc tcggcccgcc gatcggtggc gccctcatcg aggcggatgg ctggcggtgg
4175461 gtgttcctgg tgaaccttcc gctgggggta ttcgctgtgc tggccgctcg gcgggcactg
4175521 gtggagaacc gggccgccgg acgtcggcgt gtgcccgacg tgcgcggcgc ggtgctgctg
4175581 gctttcgcgc tgggcctttt gacgctggga ttgatcaagg gcccggattg gggttgggcc
4175641 agcctgccga ccagcgggtc attgctggcc gcggcggtcg cgatggttgg gtttgtgatg
4175701 agctcacgac accacccggc accgatggtc gagcccacgc tgttgcgcat ccagtcgttc
4175761 gtggccggca ccgggctgac cgccgtggcc agcgccggct tctacgccta tctgctgacg
4175821 cacgtgctgt tcctcaacta cgtctggggt tacacgctgc tggaggctgg catggccgtc
4175881 gcccccgccg cgctggtcgc cgccgtcgtc gcggcggtgc ttggccgcgt cgccgaccgg
4175941 cacggttacc gcttcatcgt cggcatcggc gcgttgatct gggctgccag cctgctgtgg
4176001 tatctcaagg ttgtcgggtc ccagcccgat ttcctcggtg aatggctgcc cggccagata
4176061 ctgcagggaa tcggggtggg cgctaccttc ccgctgctcg gcagtgccgc cttggcccgg
4176121 ctggccaagg gcggcagcta cgccaccgct tcggcggtga ccggcaccat ccgccaggtt
4176181 ggcgccgtca tcggcgtcgc ggtgctggtg atcctggtcg gcacaccggc accgggcgca
4176241 gccgaagagg cgttgcgtca cgggtgggcg ttggccgcga tctgtttcgt ggcggtgggg
4176301 atcggggcgc tgtcgctggg tcgcatccgc ccagtcccag ctgcggttga acccccgccg
4176361 gggccgccgg tggctccgtt gggagcgcgg cggccgccga gacccgcacc ggtggcctca
4176421 cccgccgcgg cagtggcccc gacccccaag acttcccgcg aagtcaacct gctggaggct
4176481 ctgcggtttg ccaggccgga cacgcaacag attgagctgc aagcaggctc gtatttgttc
4176541 cacgcgggcg atgtgtccga tgcgctctac gtggtgcgca gcggccgcct gcaagtcctc
4176601 gccggcgacg gcgcaaagga cgaagtggtg gccgagctgg gccgtggtca ggtggtcggg
4176661 gagctcgggg tgctgctcga tgcgccgcgg tccgcgtcgg ttcgtgcggt acgcgactcg
4176721 tccctgatgc gagtgaccaa ggccgaattc gcgaagatcg ccgatgccgg ggtgcttggg
4176781 gcgctggcgg gggtactggc caaacgacag caccagacac gcgtggcctc tcagcggaca
4176841 acgccggagg tcgttgtcgc ggtcgtcggt gtcgacgcca atgcaccggt cgcaatggtg
4176901 gccaccgaat tgtgcagggc actgtcgaca cggctacgtg ctgtcgcccc cggccgggtc
4176961 gactgcgacg ggttggaacg tgccgagcag accgccgacc gggtggtgct gcatgcggcc
4177021 gtcggcgacg cgcggtggcg ggaattctgt ttgcgtgtcg ccgatcgcgt ggtgctggtg
4177081 gccagcaacc cggccgtgcc tgtggccccg ctgccgaccc gagcgaccgg cgccgacctg
4177141 gtgctggccg gacggcccgc cggccgggag caccgacgtg cctgggagca gttgatcacg
4177201 ccgcggtcga tgcatgtggt ccgacgcgaa tttgtcgccg acgacctgcg ggtgctcgcc
4177261 acgcgtatcg cgggccgttc cgtggggcta gtcctcagcg gtggggcagc gagggcgtgt
4177321 gcccacttgg gcgtgctgga ggaactggag gccgccgggg tcaccgtcga ccgctttgcc
4177381 ggcaccagca tgggcgcaat catcgcggct ctggcggcca gcggtttgga tgctgccggg
4177441 gtggatgcgc aaatctacga gcacttcgtg cgcaagagcc acggcgacta caccctgccg
4177501 agcaaggggc tgatccgcgg gaaacgcacc cagtccacgc tacgcacgat cttcggagac
4177561 catttggtgg aggagctgcc gaaacatttc cgctgcgtca gtgtcgacct attggcccgg
4177621 cgtcccgtcg tgcaccgcca aggcccgctc gccgacgtcg tcggctgctc gatgcggctg
4177681 ccttttctgt atgcgccact gccctacggc ggcaccctgc acgtcgacgg cggtgtgctg
4177741 gacaacgtgc ccgtcaccac gctggtgggc aaggacggcc cactgattgc ggtaaacgtg
4177801 gcctctggcg gaaatccaag ccccgcgtcc ggcggccatc gccgcggcaa accacgggtg
4177861 cccggcctaa ccgacaccct gctgcgcacc atgacaatca gcagcgcgat ggcatcggaa
4177921 aaagtgttgg cccaggccga cctggtgatc aagcccaacc cgatcggcgt cggactcatg
4177981 gagtaccacc agatcgaccg cgcccgtgaa gcgggccgga tcgcggcccg tgaagcgttg
4178041 ccacaaatca tggagctggt gcacggctga acctgggcag ggccgctaag atactgtgac
4178101 cacggccacg ctatcggcgg cctggccagc tttccgggcc gctacccgat gggagtcctc
4178161 acccacgccg ccggcggacc caaccccgat tgttcgaccg cagacactga tctatcgcgc
4178221 aggcgttgcc gcatggtgga ctagcccaat gacgcgggct gacggcaagc gcgaccgtga
4178281 cgagatgttc gtcgaataca ccaagagcat ctgccccgtc tgcaaggtcg tggtcgacgc
4178341 ccaggtcaat atccgccacg acaaggtgta tttgcgtaag cgctgccgcg agcacggaag
4178401 tttcgaggcc ctggtgtacg gggatgccca gatgtatttg gaatcagcac gattcaacaa
4178461 accgggcacc tttccgctgc ggtttcagac cgaggtgcgc gacggctgtc ccagtgactg
4178521 cgggctgtgc ccggaccaca agcaacacgc ctgcctgggg ttgatcgagg tcaacacaca
4178581 ctgcaacctg gactgcccga tctgtttcgc cgactctggc caccaacccg acggctacgc
4178641 catcaccgcg gcgcagtgtg aacggatgct cgacacgctc gttgccgccg agggtgaacc
4178701 cgaagtggtg atgttctccg gtggcgaacc gaccatccac aaacaactcc tcgagttcgt
4178761 cgacgccgcc caggcccgcc cggtcaagac cgtcatcatc aacaccaacg gcatccggct
4178821 ggcctccgac cggcgattcg tcgaccagct cgccacccgc aaccgtcccg gccaccccgt
4178881 gcacatctac ctgcagttcg acggcctgga cgaggcaaca catcgtcgaa tccggggcca
4178941 cgatctgcgg gacgtaaagc agcgggccct ggacaactgc gccgcggcgg gcctgaccgt
4179001 cagcctggtg gccgcggtgg aacgcggcct caacgagcac gagctcggcg cggtcatccg
4179061 ccacggcatg gcgcagcccg gagtgcaacc ggtggtattt cagccggtca cccacgccgg
4179121 ccggcatgtg cagttcgacc cgctgacccg actgaccaac tccgacatca tcgcctgcat
4179181 caccgcgcaa ctgcccgaat ggttcaggcc cggtgacttc tttccggtgc catgctgctt
4179241 ccccagctgc cgatcgatca cctacctgct caccgacggg gagcatgtgg tcccgattcc
4179301 gcggctgctc aatgtcgagg actacctcga ctacgtctcc aaccgggtga tccctgacct
4179361 ggcgatccgc gaagccttgg agaacttgtg gtcggcgtcg gcggtgccag gcaccgacac
4179421 catgaccgca cagctacagc gggctaccgc cgccctgaac tgcgccgagg gctgcgggat
4179481 caacctgccc gaggccctca cgcacctcac cgaccgggtc ttcgccatcg tcatccaaga
4179541 cttccaggat ccctacaccc tcaacgtcaa acagctgatg aaatgctgcg tgcaacagat
4179601 caccccggac ggacggctga tcccgttctg cgcctacaac tcggtcggct atcgagagca
4179661 ggtgcgtgaa cagctcaccg gggtaccggt acccgacatt gtgcccaatg ccatcccact
4179721 cgccgggttg ctggcggacg caccacacgg atcaaaacag gccaataccg gtgggagtat
4179781 cgccaggctc gcggggccaa cccgaggtgc gccgatggca ctgccaccac agcagatcaa
4179841 agcgtgttgc gccgacgcct attcccgcga catcgtcgcc ttgctactcg gtgactcctt
4179901 tcacccgggc ggcgcgacat tgacccgtag gttggctgac caactcgggc tgaggtcgac
4179961 aggcgacccg cggcgggtcg ccgacatcgc cgccgggccc ggcgcctccg cacggctgct
4180021 ggccagcgac tacggtgtgg ctgtcgacgg ggtcgacatc agcgagatca acgtgaagcg
4180081 cgcccaagcc gccgtcgcgc aaaccggcct gaccgagcgg gtgcgcttcc acctgggcga
4180141 cgccgaatca gtcccgttgc ccgacgacac attcgacgcg ctggtgtgcg agtgcgcgtt
4180201 ctgcacattc ccggacaaga acgccgccgc ccagcagttc gctcggattc tgcgtcctgg
4180261 tggcctggcc ggcatcaccg atgtcactgt cggggacggc ggcctgccgg cggagctgac
4180321 cccattggcc gcgtgggtcg cctgcatcgc cgacgcccga accgtcaccg actacaccga
4180381 catcctcgaa ggggccggat tgcgcacccg ccacatcgag tctcatgacg agagcctgct
4180441 ggacatgatc gaccgcatcg acgcgcggat caccgccttg cacgtcgccg caccggagat
4180501 cctcgccgac aacggcattc gccacgactc ggtgcgcgat ttcacagcgc tcgcacgcgc
4180561 cgcggtacaa accggacgaa tcggatacac gttgatgatc gcggaaaagc cgtgataatc
4180621 caggaaatgt gggacagacc aatcgcattt cccgcatctg aggagcgagc cgcaccgcgt
4180681 tacttcgacg tgtttccccc cttcaagtcg gtatcccggc tcggctgcac ccgcttgggt
4180741 tcgcccggca tcttcggata gttcggcgga tacggcatgt caccgagccc gcgctcctcg
4180801 tcggcggcgg ccaagtccag caatggtgca atcgactggg ccacgtcgtc catgccggcc
4180861 caggggtcgt cgcggatctt caccagctcg ggcaccgtgg tcatggtgta gtcgtcggga
4180921 tccgcgccgg ccagctcttc ccaggtcaac ggcatcgata ccgtcgcgat cggggtagga
4180981 cgcaccgaat aggccgacgc catggtgcgg tcgcgggcgt tttggttgaa gtcgatgaag
4181041 atacgcgcgc cccgttcttc cttccaccac gacgtcgtca ccgcatccgg tgcgcggcgc
4181101 tcgacttccc gggccaacgc aatgcccgcc cgacgcacct cgacgaagtc ccagtcggtg
4181161 gcgatgcgca ggaatacgtg aatccctcta cccccggatg tcttcggata accgaccaga
4181221 ccgaggtcgt ccagcacgga ccggagcaca tcgacggcga ccgtacgcgc ctccacgaag
4181281 ccggtgcccg gttgcggatc tagatcgatg cgcaattcgt cggggtgctc ggtgtcgggg
4181341 cagcgcactt gccacgggtg cagggtgatt gtgcccatct gcgccgccca tacgatcgcc
4181401 gccgggtggg tcaccttcag cgcgtcagcc atccgccccg acggaaacgt cacccggcac
4181461 gtctgcaggt agtcagggcg gtgccgcggg atccgctttt ggtagatctg ctcgccgtcg
4181521 acgccgtccg ggaagcgctg caagtgcgtc ggccggtcac gcagcgccgt cagcatcgga
4181581 cccccggcca cggcgaagta gtactcaacg aggcggcgct tggtgccgtg cgaccccagc
4181641 ttcgggaaat acatcctgtc cgggctagtc aaccgcaccg cgatgccgtc gacgtcgagt
4181701 tcctcagctg ccgccgccat atcggaattc cagcatgccg cacgcaagaa tgagcacatg
4181761 cagttacccg tcatgccgcc ggtgtcgccg atgctggcca aatcggtcac cgcaatcccg
4181821 ccggacgcgt cgtatgaacc caaatgggac ggattccgct ccatctgctt tcgcgacggt
4181881 gatcaggtcg aactgggtag ccgcaacgag cggccgatga cccgctactt ccccgagctg
4181941 gtcgccgcga tcagggccga gctgccgcat cgctgtgtga tcgacgggga gatcatcatc
4182001 gccaccgacc acggcttgga cttcgaggcg ctgcaacagc gcatccatcc tgccgagtcg
4182061 agggtgcgaa tgcttgccga ccgcacacca gcctccttca tcgcattcga cctgctggcc
4182121 ctcggcgacg acgactacac cgggcgaccg ttcagcgaaa gacgagccgc tctggtcgat
4182181 gccgtaactg gttcgggggc cgacgctgac ctgtcgatcc acgtcacccc ggcaaccacc
4182241 gacatggcga ccgcacaacg atggttctcc gagttcgagg gggccggtct agacggtgtc
4182301 atcgccaaac cgccgcacat cacctatcaa ccggacaaac gcgttatgtt caagatcaaa
4182361 cacctgcgga ccgccgattg cgtggtggcc ggctaccggg tgcacaagtc cggcagtgac
4182421 gcgatcggct cactgctgct agggctttac caggaggacg gccaactcgc gtcggtcggc
4182481 gtgatcggcg cgttccccat ggccgaacga cgccggctat taaccgagct gcagccgctg
4182541 gtcaccagct tcgacgacca cccatggaac tgggccgccc acgttgccgg ccagcgcacc
4182601 ccacgtaaga acgagttctc ccgctggaat gtcggcaaag acctgtcgtt cgtgccgctg
4182661 cgacccgagc gggtggtcga ggtccgctac gaccgcatgg aaggcgcgcg gttccgccac
4182721 accgcacagt tcaaccggtg gcgccccgac cgcgacccac gctcatgcag ctatgcccag
4182781 ctcgaacgcc cgctcaccgt cagcctctcc gacattgtgc cgggcctacg ctaaggtgcg
4182841 accctcttcg gtcagttgat ccccggtggg ccgatcggct cgggcgccac atccgggtcg
4182901 gttcgttgcg ttcggccgcg taacatctgc ggcatggcgg tgctgcccgc gtgccggttg
4182961 ggacttgtcg tctgtgtggc gaccgcagtg atcacagcaa ccatggtgtt ggctacgccg
4183021 agctatgcat gcgcctgcgg tgccgcggtc acagcacatg gctcccaagc aactttgaat
4183081 catgaagtcg cgctgcttca ttgggacggg acgaccgaga cgatcgtcat gcagctggca
4183141 atgaacgccg ataccgacaa cgttgccttg gtagtgccca ccccgacgcc ggcgatagtt
4183201 acaaccgcgg accagtccac gttcggcgag ctggacacgc tcagtgcgcc gttgatcgag
4183261 catcagcgac attggagctt aaggcgcggt gtcggtgcct ccggtcccca ggaggccgcc
4183321 gcccgggccc cgcatgtgct caaccaggtt cgccttggcc cgctggaggc caccaccttg
4183381 accggcgggg atctgagcgg cctgcagact tggttgtctg acaacggcta tgcgattcga
4183441 ccggcggtgt cagcggcgct ggatccctac gtgcgtgacg gatgggcgtt cgtggcgatc
4183501 cggctgacca gcaccgacct gatagtgggc gggctcgatc cggtgcggat gaccttccga
4183561 tcgtcgcggt tggtgtatcc catgcggcta tcggtcgccg cccaggagcc gcaacatgtc
4183621 accatcttca ccctgtccga tcaccggcag cagcgcaccg acgccgacgc tgccacacag
4183681 acaacccacg tccggttcgc gggcgacatg tccactgcgg ttcgtgaccc tctgttgcgc
4183741 gagctgatcg gcaaccacgg ctcatatctg accaaggtcg aggtggacat ctatcagaca
4183801 tcgcgaatct cttcggattt cacgttcggc aacgcaccaa acgacgatcc gtaccggcag
4183861 gtggtcaccg tttacgacga tgtcgcactc cccccgctgc tgctggtggt cgtgtcggcg
4183921 atcgcggtgg gcgcggcggg cggggccgtt gtggtggttc tgcggcgacg gcggcgcgcc
4183981 cacactgggt agtccgccac ggtgagggcg ctcagcgagg cagggattct ggtccttcag
4184041 acaaacccgc cacggccggg tgcgccatca accggtcgag aaaaccccgc tgccccttga
4184101 gcagtttggt gcgtgcccgc gctaccggaa accagctcac ccggtcgacc tcggggaact
4184161 tacgcatctt gcccgagccc ttcggccagt ccaattcgaa ggtgctgctt cgtgcgtcgg
4184221 tgatgtccag atccgcccgg acaccgaaca cggtcaccac cttgccgccg gactgtttca
4184281 gcgacccgaa gtcgattcgc ggcccgtcag gcacgcacaa cccgatctcc tcggagaact
4184341 cgcgccgggc ggccagccac ggatcttcgc cgccggtgta ttcgcccttc gggatcgacc
4184401 aagcgccgtc gtcctttccc gcccaaaacg ggccgcccgg atgcgccaga aggacgtcga
4184461 cgacaccggc gcgcgcccga tacagcagca cacccgcgct gagcttgggc atgagtacgg
4184521 gttctttaga tcccgacggc ctgttccaga tccttcagcg acgattccag gtgcgcaagc
4184581 agccgctgca agtggggcac actgcgacgg cacccgacca gtccgaagtc gagattccca
4184641 gcattgttca ccagggtgat gttcaacgct tgaccgtccg ggatgttcga caatgggtaa
4184701 ctaccgtcaa gccgggccgt gccgtagtag agcgggtcta ccggccccgg cacattcgag
4184761 atgacgatgt tgaacggtgg cggcactgcc gacaagaaac ccggtacacc cgccaacgtc
4184821 agcggcgcca tattcaatgc cgacaatgca agcacctgca gctgcggcaa ttcggagagc
4184881 actttcttgt tgccgtccat ggacgcgctg atggtctgaa tccgttgcgc tgggtcgtcg
4184941 acatgggtgg cgagattgca caggacgctg ccgaccaagt tgccgccggc gtcagcgtcc
4185001 tctttggagc gtaggctcac cggaaccatc gcgatcagcg gtctgtccgg cagcgcattc
4185061 cgctctatca ggtagtagcg caacgcaccg gcacacatcg ccaggacggc gtcgttgacg
4185121 gtcacaccgg cggcctgctt gacgctcttg atccggtcca gcgaccagga ctgcgcagcg
4185181 caccggcggg ctcccccgac cttgacgttg aacatgctgt gtggcgccgc gaacggcagc
4185241 gtcaactgct gctcgagtag cgccgcacga gccagcttca gcgtcgacgg tgcaagtccg
4185301 acaacggatc ccgccatctt gaacagcgca tccaacagtg acgagccgtc cgatggcggg
4185361 cgcgtacgtg ggcgcggagg caggttccag atggcgcgca cctcggcgtc gtccgggtca
4185421 gccgacagcg tgcgctgcgc cagcttcatc gccgaaacac cgtcgatcag ggcgtggtgc
4185481 attttggtgt acatagcaaa ccggccgtcg ttcagcccct ccaccacgtg cagctcccac
4185541 agcgggcggt ggcgatcgag caggctggta tgcagccttg aggtcagctc gagcagatcg
4185601 cggactcgtc ctggcgaggg cagcgccgag cggcgaacgt ggtaatcgat gtcgatgtcg
4185661 tcgtcataag cccatgccac acgggcgatt ccacccccga tcgtcgcagg gtgctttcgg
4185721 aacatgggct ggaattcgtc gttggcaacc aaacgctcgg tgaactcacg gacgaactca
4185781 ggaccagctc cctgcggtgg ctcgaacaac gacaagccac ccacatgcat ggggtgttca
4185841 cgagattcaa tgaaaagaaa catcgagtcg ttgggcatca tcagatccat gcacccatta
4185901 cacccattac cgagtgatcc gggaaggctt ctgtggtgcc cgaggttcgg caagtcgcaa
4185961 gaacatcgcc gcccagctga cttcgggatg acaacgcatg tagtccggag cggcttgagg
4186021 ttgcaacgtc gggtgggcga agtagtccgg ctgagaggta ttggtggcag catgggtttg
4186081 tgacctcaat gtcgttggcc tgggatgtgg tgtcggtcga caagccggac gatgtcaacg
4186141 tcgtgatcgg ccaggcgcac ttcatcaaag cggtcgaaga cctgcacgag gccatggtcg
4186201 gcgtgagccc atcgctacgg ttcgggctcg ccttttgcga ggcttccggg ccccggttgg
4186261 ttcgacatac cggcaacgat ggcgatttgg tcgaactcgc gacccgcact gcgctggcca
4186321 tcgcggccgg gcatagcttc gtgatcttct tacgtgaggg gtttcccatc aacatcctca
4186381 acccggtgca ggcggtgccc gaggtctgca cgatctactg cgccacagcc aatccggtcg
4186441 acgttgtcgt cgcggtgacc ccgcatggtc gcggcatcgt gggtgttgtc gacgggcaga
4186501 cccctctggg agtggagacc gatcgcgaca ttgcgcagcg gcgtgacctg ttgcgcgcca
4186561 tcggttacaa gctctgatac gggccgccgg tccgcccttg acagcgggac gtccgccgca
4186621 gagggtcgac ggcatgtccg tggtgcgcgg gaccgctctg gctaactacc cgagcctggt
4186681 tgccgggttg ggcggtgacc cggccactct gctacgggcc gcgggtgttc gggatcagga
4186741 tgtcggcaac tatgacgcgt tcatttcgat ccgggcagcg attcgggcaa tcgaatcggc
4186801 cgcagcggtc accgccacaa tggatttcgg gagacgattg gcacagcggc aagggattga
4186861 gatcctggga ccggtcggtg tggcggcccg cacggccgcc acggtcggtg acgctctggc
4186921 gatcttcaac accttcatgg cggcctacag cccagttatc gccatccgga tcacgccgct
4186981 ggccggacag cggtcattta ttgcactcga gttcctgctc gacgagccgg cgtcgtatcc
4187041 gcagaccatg gagctggcgc tcggggtggc gctcggggtg atccggttgt tgttgggcgc
4187101 tgactacgcc ccactggccg tgcacttacc ccacgaccca ctcacacccg aagccttcta
4187161 cctgcagtac ttcggctgcc ggccttactt cgccgaacgt gttggtggtt tcaccatgcg
4187221 caccgcggac ctgagccgtc ccctcaaccg cgacgatgtc gcccaccggg tggtcgtcga
4187281 ctacctgagc agcatcacgc cgctgggcga ggggatcgtg gaatcggtgc gcaccatcgt
4187341 gcgccagctg ctgcccaccg gagcggcgac gctcaacgtg gtcgccgagc agttccacct
4187401 gcacccgaaa acgctgcaac gtcgacttgc ggaggagaac accacattcg ttattctggt
4187461 cgatcgggtc cgcaaggatg tcgctgatcg ctacctaagg accaccggga tcggccttac
4187521 ccatttggca cgtgaactgg gctacgccga acaaagcgtg ttgacccgct cgtgcaaacg
4187581 ctggttcgga accggaccgg ccgcctaccg caaccaggcc aggttacaga caaccgtgag
4187641 cgcacctggc agcgggcgtg gtccgaatcc aggtaacgtc tcagtatcct gctgaccgat
4187701 ggatcaagat cgatcggaca acacggcatt gcgccgtggt ctgcgaattg ccctgcgcgg
4187761 gcgccgcgat ccgctgcccg tggcgggccg gcggagccgg acctccggcg gaatcgatga
4187821 cctgcacacc cggaaggtgc ttgacctgac catccggctc gccgaggtga tgttgtcgtc
4187881 cggctctggc accgcggatg tcgtcgccac agcccaggac gtggctcagg cctaccagct
4187941 caccgattgc gttgtcgaca tcaccgttac caccatcatc gtgtccgcgc tagcgaccac
4188001 agacactccg ccggtcacca tcatgcggtc ggtccggacc cggtccactg actacagccg
4188061 gctggccgaa ctcgatcgac tcgttcagcg gataacctcc ggtggcgtcg cagtcgacca
4188121 ggctcacgag gctatggacg agttgaccga acggccccac ccctacccgc gctggctcgc
4188181 gaccgcgggg gcggcgggct tcgcactcgg cgtcgccatg ttgctcggcg gaacctggct
4188241 gacctgcgtc ttggctgccg tgacgtctgg cgtgatcgac cgactgggcc ggctgctgaa
4188301 ccggatcggg accccgttgt tcttccagcg cgtgttcggc gcggggatcg cgaccctggt
4188361 cgcggtggcg gcttacctga tcgccggcca ggatccgacc gcgctggtgg ccaccggaat
4188421 cgttgtgctg ctgtctggga tgaccttggt gggttcgatg caggacgcgg tcaccgggta
4188481 catgctcacc gcactcgccc ggcttggcga cgccctgttc ctgaccgcag ggatcgtcgt
4188541 cggcatcctc atctcgttgc ggggcgtcac caatgccggc atccagatcg aactgcatgt
4188601 cgacgcaacc acgacgctcg ccaccccggg catgccgcta ccgattctcg tcgcggtaag
4188661 cggtgcggcg ctgtccggcg tgtgcctgac gatcgcgagc tatgcgccgc tacgttctgt
4188721 ggccaccgcc ggactctcgg ccggactcgc cgaactggtg ctcatcggac tcggcgcggc
4188781 cgggttcggc cgagtggtcg ccacctggac cgccgcgatc ggcgtcggct tcttggccac
4188841 cctgatctca atccgtcggc aggctcccgc cttggtgacg gccaccgccg gcatcatgcc
4188901 gatgctgccg ggccttgcgg tcttccgtgc cgtgttcgcg ttcgccgtca atgacacacc
4188961 cgacggcggt ctgacccagc tgctggaagc ggccgcgact gcactcgcgc ttggcagcgg
4189021 ggtggtgttg ggcgagttcc tcgcctcacc attgcggtac ggcgccggcc ggatcggcga
4189081 cctctttcgg atcgagggtc cacccgggct ccggcgggcg gtcggccgtg tggtgcgcct
4189141 acagccggcc aagagccagc agccgaccgg caccggtggc caacggtggc gaagcgtcgc
4189201 gctggagccg acgacggccg acgacgtgga cgccggctat cgcggcgatt ggcccgctac
4189261 ctgcaccagc gcgaccgagg tgcgctagcc agcctcgcca gcgccgacca actgctccca
4189321 gctagcgggc accatcggca ccgacggact acccccgaac tcaccaccgg ccaacgtggt
4189381 caaccccgca ggacgcccaa cggactcctt gccagcggtc ccggcaaacc ccaacacgcc
4189441 ggcaccccga tccgaagcca gcaccgacgc cgacgtgccc gcgggagctg gcgccaccgc
4189501 cgacaccagc ctggcctccg gtcgcaccgc ggcagactca cgcaacggcg gcgccgctgc
4189561 aggtcgtacg gcaacgggcg ccacgtccgc cgtctttagg cccacttcga tagcctgcgc
4189621 gtccgcactc gccaggtccg cgaggtactg gccaacgccg ataggcaccg cagtcgacaa
4189681 cgaagtcgac aacgaggtcg gcaccgcaat cacggagccg gtgagcacaa atggcgatgc
4189741 gatcacaagg agcggcgggc cgaagatgat cgccaggacc gcaaagacga tcgcgtatgc
4189801 gaagatcacg agcggcaaga tgagcacgat gatgatcgtg tatgcgacga ttgcaaacag
4189861 gatctcgagc gatatcagaa agagctgaat caatatctcg atgatgatcc cgatgatgct
4189921 ggcggggtcc aacgttgcgg cggagatcgc cggcagggcg ctggcaacgc cagcaccgcc
4189981 gttgaacagt accggagccg gtgtggtttg cggtgccgac gccagcgccg catcggaggt
4190041 gccctcatag atactcatcg tggtggccgc ctgaatccac atccgcgcat agtcggcctc
4190101 attgagcgcg atcgggatcg tattgattcc aaagaaattc gttcccagca acaccgcatg
4190161 gctggtgtga ttagcggcca actcggtcag cgtcggcatc gccgccagcg cgctggcata
4190221 tgccgtggtc ataacctcat gctgggtggc cagccgcgca ctgtcggcac tggatttagt
4190281 tagctaggct agataaggta ggtgggcggc cacataagct tcggcgctcg gaccctccca
4190341 cgccccgccc tgtaccgctg ccagcaccgc agtgagctct tgggctgccg aagcatactc
4190401 cgcactcagc gatgtccatt ccgcggcagc cgcctgcaac gaagccgggc ccggaccggc
4190461 gctgagcaac gccgaatgca cctccggcgg cgaggcaaac cagatgggcg ccgtcatagt
4190521 gagccccctg aaaccgaatc caccgccggc gacagcgcgg ccgccgccaa accatcagga
4190581 actaccccct gcgtcactcc tcgtactcct tcggtcatct caccgaccaa ccgcagccga
4190641 aagccggtca gtcaactgac tgggccaagt cgcacacatg acggactata gatctcacgc
4190701 aatatagcga taatcgatca tttccacgag ctacgatgct cgagttgccc agccagcaag
4190761 atacgtccct ttacaccagg cagataaact gggctggctt tggtcaaacc cagcgcgacc
4190821 cgcagcactt cctcatagcc cgaccgcgcg ctccagttcc ttcaacgagg tctccagatg
4190881 gctgagtacc cgctgcacgt gtggaacgct gcggcggcaa cccacgactc cgaagtcgag
4190941 actatcggcg gtgctggtca gggtgatgtt gagcgcttgt ccgtcgagca ccaacgacat
4191001 tggatagttg ccgaccatcc tggcgccgtt gaagtacagc ggttcgcgcg caccgggcac
4191061 gttcgagatg cacacattaa acggcggtgg cgttgccttg gccaagcccg gcagggtgtt
4191121 cagcgcagct gggctcaaca gcagcagtga caccgccaac gcctgggcgc ggggcagctg
4191181 cgatagtacg ttcttattac cgcgcatcga agcgtggatg gcgttcagcc ggtcggctgg
4191241 atcatcaagg tgggtggcca gattacacaa caccgccccg accatgttgc cgccgaccga
4191301 gtcgcggtcg gtgcgcaggc tcaccggaac catcgcaacc agcggcgtgt ccggcagcgc
4191361 gtcgttgtcg tccagatatt cgcgaagtgc gccggcgcac atcgccagca ccacgtcgtt
4191421 gaggctgacc ccggccgcgt ctttcaccgc cttgacccgg tccaacggcc aggactgcgc
4191481 ggcgcagcgc cgcgctcccc cgacggcgac attgagcatg gtgtgcgggg ccccgaaggg
4191541 cagtgtcaac tgttgttcga tcaacgcgga acgcgccagt cgcaacgttg agggagcgag
4191601 cccggcaacc gatcccagca tgccccccag ctgttgcagg cggccgcgcc gtcgcttgat
4191661 ggcggtgtgc tgcgtcgccg gtgaccaggc ggtgcgcaac ttgccctcga tggggtcggt
4191721 ggtcatcggc tggcgcatca gcgtaagtcc ggacaccccg tcgaccaggg cgtggtgcat
4191781 cttcgaatag atcgcaaagc gtccatcccg gaggccctcg atcacgtgtg tttcccagag
4191841 cgggcggtgc cggtcgagca gattggagtg taaccgtgac gtcagttcca gcagctcacg
4191901 cacccggccc ggcgccggca gggcagaccg ccgcgcgtgg tagccgaggt cgacgtcagc
4191961 gtcggtcgac cagccgaggt tgatgagtgc accgtgaagc gacgtggggc gcttgcgaaa
4192021 tagcggtgct atctcgcggc actgaagcat cgcctgatag gtttcccgca caaacccacg
4192081 tcccgccccc gcgggtggct cgaacagttg cagcgcgccg acatgcagcg gatgctctcg
4192141 cgactcggct gataagaaca gcgcatcgat cggtgacatc agttccatgg cgtgctcctg
4192201 gtgatgcgct tcaccgtcag ccggctcgcc gaagccgacg tcgtaaagcg caggtgatcg
4192261 tcgtcgaccg ggccctcgcg caacaccttg aggtccgcca gggggcttcg gcgccctgca
4192321 gcggccgggt cggcatggct gcgggcagct gcggacagca gatggtgtgc ccgggtgcgt
4192381 ccatgtgggc cggcgaagtt ggacacgtcg ctgagcagga aacccttgaa tgccaccttc
4192441 tcggcaacgt ccacggcgac tccgtcgacc gagaggttga tgccaccgaa ggccagcaga
4192501 ttgaggccgg tggcagtgat gctgatgtcg gccgccaatt cgcgtccgga ttgcagccgg
4192561 attccgtttt cggtaaaagt atcgatcgcc tcggtgacca ccgaggcccg gccgtcgcgg
4192621 atggccttga acatgtcggc atctggcacc gcgcacaggc gttggtccca tgggttgtag
4192681 accggcttga agtgctcgtc ggccggatat ccggcggcca gctgcttggc gttgagatga
4192741 cggatcagtc gccgggcggc tctcggatac cgttggcata accgccacac caaccgttgc
4192801 ttggcgatgt ctttgcgccg ggtgacggcg taggcccgat cgcggcctat catttgggca
4192861 tggttaccgc gccggcggtc tgggccatgg ccggcaccag cgtgaccgcg gtcgcgccgc
4192921 tgccgatgat caccatccgc agctcatggt gacgtgttcg ccggtgtcga agcgttcgat
4192981 ctccaccagc cagcgagcgt cctcggtgga ccatgatggc gtccgcgctg gcggtcgcct
4193041 tctcgtgctg ccacggcttg aactcatagc tgaacgtgtg caggtcggag tcggatcgaa
4193101 ttgctggata ccgggcttca acgatcgcga atgtcttggc cggctgcatt gtctttaggt
4193161 agtaggcggc gccagtgccg gagatgccgg cgccaacgat cagcacgtcg acgtgttcga
4193221 tgctggctga ctgctcggag tgcacggcgt acttcctgtt cgggcgaagg ctgacccgcg
4193281 acttcgttgt caaccggggg tggtgtgcgt caccgaactc actgtgcacc agcactcggc
4193341 cttgagtctt gacactagaa gacaacaatt tgacttttca agacacagcg tcacctgtgc
4193401 gcggtgccag cggcgcggcg ccaggccgtg tggcgcagta ggcgcagccc attgagtccg
4193461 acgatgatgg tggaaccttc gtgtcgggcg acgcccagtg gcaatggcaa cgtgaaggcc
4193521 aggtcccaca caacgagccc ggcgatgaat gtcacggcca cgatgaggtt ggcgaccacg
4193581 atgcggcggg ctcgccgcga catggcgata acggtgggaa tggtggtcag gtcatcgcgg
4193641 acgacgacgg cgtcggcggt ctgcagggtg agttccgatc gggcgctgcc catggcgatg
4193701 ccgacatgcg cggccgctaa ggccggagcg tcgttgatac cgtcaccgac cacggtcaat
4193761 ctggcacctc cagcttgcag ctgccgcacg gctgcgacct tgtcgtcggg cagtagcccg
4193821 gcccgtacgt cgtcgatgcc aacctgtaca ccgagccgat cggcggtggc ccggttgtcg
4193881 ccggtaagca ataccggttt ggccccggtc agtttggtcg cagcggaaat cgccgcggcg
4193941 gcttcggggc gaagctgatc ggtgatggcg agtagcccga cgggatggct atcgcatacc
4194001 acgacgacga cggtgtagcc ctcgccttgc agaaagtcga ccgccgtgat catggaagct
4194061 tcgagcgcgg cggcgccggc agtgcccagc agtgccgtcg ccgatccgac cgcaatgacg
4194121 tggccatcga cgcgggcggt gacacggcaa cctgggtgtg cggtgaactc gccgacggtc
4194181 ggcagccgga tgcggcgaga ctgggcggct ttcacgatgg ccgcacccag tgggtgctca
4194241 ctgggatact ccgctgcagc cgcaagccgc agcagttcat catcggtgaa tcgtcgttcg
4194301 tacacccaga tgccggcgag ttcgggggta ccgcgggtaa gggtgccggt cttgtcgaac
4194361 gcgatccgtg tggtggttcc aagttgttcc atcacgatcg cggacttggc gagcaccccg
4194421 tggcggccgg cgttggcgat tgcggccaat agtggcggca tggtggccag cacgaccgca
4194481 cacggcgacg cgacgatcat gaacgtcatg gctcgcagca acgcccgctg cagggtctcc
4194541 ccccatagcg ggggcaccgc gaatacggcg agggtcacgg cgaccatgcc gatcgagtag
4194601 cgttgttcga ctttctcgat gaacagctgg gtgcgcgcct tggtctggct ggcctgttca
4194661 accagggtgg caatgcgagc gacgacggaa tcccgcgcga gccggtcgac ccggatccgc
4194721 agggcgccgg tgccgttgac agtgccggcg aacacctgat cgccgattga cttgtcgacg
4194781 ggcagcggct ctccggtgac ggtggcctga tcgacttcgc tgccgccggc aagcacggtt
4194841 gcgtccgccg agatgcgctc accgggccgt accagcacga tgtccccaat ccttaggtcg
4194901 gcggcgttga ccgtttcctc accaccgccg gcgcccacgc gggtcgcggt gcccggcgcg
4194961 aggcccatta gcccacgcac cgagtccgcg gtgcgggccg ttaccagtgc ttccagagca
4195021 ccggaggttg cgaagatgac aatgagcaga gcgccctcgg cgatctgccc gatggcggcc
4195081 gcgccgatcg ccgcgaccac catcagcaga tcgacatcta gggtccttcg ctgtagcgcc
4195141 tgtagcccgg ccagccctgg ctcccaaccg ccggtcgcgt agcacgccag aaacagcgcc
4195201 caccgcaccc attgcggtgc tccgcacagc tgtgtcagta gtcccgctga aaacaggccc
4195261 aacgccagcg cggcccaacg catctccgac aacgcgaaca gcttggttcg gcgcgctagg
4195321 accaacggcg acgctgaggt gcaccgggcg ggagagagtt cacgaacagc cacccggcca
4195381 acatatcaga atatatgatc atatgttcat ttatttcttt ggggataggc tgcctaacca
4195441 tggggcacgg ggtcgaaggc aggaatcgtc cgtcagcgcc gttggattcc caggccgccg
4195501 cgcaggtcgc gtccacactg caggcgttgg cgactccgag ccggctgatg atcctcaccc
4195561 agctacggaa cggcccgctt ccggtaaccg acctcgccga ggctattgga atggaacagt
4195621 ccgccgtctc gcatcaactt cgagtgttgc ggaatctcgg cttggtcgtg ggcgaccggg
4195681 caggccgtag catcgtctac agcctctacg acacgcatgt ggcgcagctt cttgacgaag
4195741 ccatttacca cagcgagcac ttgcaccttg gtctctccga ccggcacccc agcgcgggct
4195801 aagcggtcag gctcataagc tcgcgggtca ctttcaccca tgaccggcga gctttacaga
4195861 ccccagcgcc tcaaggggca ccacctcaag ggcgcagcca ccgtggcggg cgcgcaatcg
4195921 acaggtcgtt gccgaccgag cgctggtgtg ccaggaattc ggtggtcatg acggcgcaga
4195981 tggtgtgcca accgaggtcc tcgggtccgg tcgcacagca gccgtcacga tagaagccgg
4196041 taagcggatc ggtgccaccc tgttccaggg cgccgcccag cacattgcaa tcggacatgg
4196101 acctaagtgt ctaagctgcg ccagccacgc cgtcggacct atcagctaat tcggcgcgcg
4196161 tcgcggcgca ctattcccgc gcgagggtct ggccgggtcg cggaattgct tcgagcaagc
4196221 aggcggccgc cctgacgtcg gcgtccgaat acatccgggc gatcgcggta aacacctcgc
4196281 ccgcctttct cagctcttcc tgcgccgctt gattcagcgc cagcagcccg gtggccgccg
4196341 tcgtgaacgc cgttaccgcc cacgccgaca cctcctcggc cccggcgggc aatagcgagc
4196401 tcagcgagac ccacgccacc gcaccggcct gtagcccttg gaatgcgttg ttgacgacct
4196461 gcgatccgat gtcggcaacg gccggatcga atgacatgga ctgcatgtgt ctctccctag
4196521 attgcgcggg ctcgggcccc aacgacgaga tctaagcgag gaattcagtt gtcggtagcg
4196581 atagtagtaa taggatatag tccgcgctga cgaaatagaa gacgagatat gccgtcgcac
4196641 tgaataattt gtcaccaagg gcgctgccgc cccgtgctac ccctgggcat gttgtccacc
4196701 tgcggcgcgg taggttcagc ggcgtgatac ttacgggtgc gttcttggcc gatgccgccg
4196761 cagcggtgga caacaaactc aatgtgcaag gcggcgtgct gtccagattt gcggtcggtc
4196821 ctgaccggct ggcccgattt gtgttggtgg tgttgacgca ggcggagcct gacagttcgg
4196881 accgcgacat tacggtcgag atgaggccgc cgaccgatga cgaaccgata cgcctgaatt
4196941 tcgaggcgcc cgaagcggcc gttgccgagt tccccggatt cgcattcttc gaaatccaac
4197001 tgcgcctgcc ggttaacggc cgttgggtgc tggtggtgac tggcggcacc ggagcgatat
4197061 cgcttccggt gctggtgagc gacatgcctg cgacgatagg tttttgacgc gccggtcttg
4197121 agcgacgacc cccggggctt gcagaaaggt tgtcccgtgc accagcagca tccctacaac
4197181 gcagctggat tcggctgacc gtgctgacac ccaacccagc ggtaggttcg gcagcgtgat
4197241 agtcggggcc ttcctcgccg aagcggcctc ggtggtggac aacaagctca atgtctccgg
4197301 cggcgtgctg taccgatttg cggtggatcc ggaccggtcg gcccagtttc tgctggtggt
4197361 gttgacccag gccgagaccg atgatccgga tcggcgggtc gacgtagagg tttggcctcc
4197421 gacgggcgac gacgcgcacc acatcgagtt cgagctaccc gaggccgccg tcgccgccga
4197481 ggtcggattc gccatcttcc ggatcgaggt aaacctgccc gtcgacggcc gttgggtgct
4197541 ggtggtaacc ggcggcgccg gaacgatctc gctgccgctg atcgtgacgg ggtgaggcgt
4197601 aggcccctgc cgacggagct gccagcccta ttgatcgaat gggagcagga cgccgaggcc
4197661 gaatggcgat ccggacggga acagacgccg tgccttagcg gcgaactgtg ggacctgctc
4197721 gcccagcgca tctagcaggc tgtgcggcgt gaacggcggg tcgatgtagg cgtcgaccat
4197781 cccgaggatc actgctttcg ttgcctcttc gtacaaatcc aactgatcga ggagaaagtc
4197841 gtcgggatgc aaagctttga tctgataggg ctttagcgcg tcatcaggga agtgcttgag
4197901 gtttgtcgtg actatcacct ccgcgcgctc tcggaccgct gcagctagca catgtcgatc
4197961 tttgtaatgg ttgttcatgg cggcgatgag gtcgttgtac ccgaaagcga atgcggtagt
4198021 cagcccgttc ggtgctgatg ttgaggcggt cgaccatggt tcgccgagtc tcggccagga
4198081 tgtcctccga ccacagaggc cgataggtgc cctcgtcagc gaaccgcaac agggcatcaa
4198141 ccagcgggtg tggcacgagc acgcacgcgt ccagtactac ggggaacggc atgctcggcc
4198201 tcctctactt cttttctgca agcgccgcct ggagctcacc aagggcgtcg cggctcaact
4198261 cgcctagtgc tgcacggcga ttcgaccggg tttcttgctg atattcgagc agcgcgtcaa
4198321 ggctcactcg gcggtggcgg cccggcttct caaatgggat tcgaccatcc tccaagagcc
4198381 gaacgagggt cgggcgtgag atgttcaata ggtcggcggc ttcttgggtg gttagtttga
4198441 ggtggcgtgg caccaatgaa atgcctttgc cttgcgacaa ggccagcacg acgttgtaca
4198501 gcgcatctct gactggttca ggaagcgtca tcggttgtcc ggcgttgcca cacacggaaa
4198561 cttcaggcgc gccaagcacc tccagcaagg aggtcatgtc ctgcgggtcg cgggggtgga
4198621 agtactgtcc gttcctggac tgcggctgtc atgcagctta gcgtaattcg aacaaaacga
4198681 aacgtcgagt ctctgaccag gcatttacgc aagctactgc gccgctaacc gcgccgggtc
4198741 gcgcacttgg ccgcctcaaa cgccgcctag cacggtgacg tcgagcccgg cggagcgcac
4198801 cagctgatca gagctggaaa ccggcgcgcg tctgccgcgg ccgaagccta cacgcgggcg
4198861 gatctgcggc gcggtgaagc gcgcaaaggt ccagcagatc actccgcacg atttgcggca
4198921 caccgcggcc agcttggcgg tgtcggccgg cgtcaacgtt ttggcgctgc aacggattct
4198981 cgggcacaag tccgcgaagg tcaccctgga cacgtatgcg gatctcttcg atgccgatct
4199041 tgatgcagtc gccgtcactc tcgggaaaga tgccgaccag caaacctgaa aataccctgc
4199101 tgaactgcac taacagtcaa agggatttgg cggtggcgga gggatttgaa ccctcggacg
4199161 gtgttagccg tcacacgctt tcgaggcgtg ctccttaggc cgctcggaca cgccaccgcg
4199221 gtgaagctta ccgaatcggc gcaccctcac cccaatcgct ggcgggcgaa gaaggcctcc
4199281 agcggcgcgg cgcactcccg cgcgagcaca ccgccgcgta cctccgggcg gtgattgagc
4199341 cgacgatcac ggaccacgtc ccacaacgag ccgaccgccc cggtcttggg ctcccaggca
4199401 ccgaagacca gccgcgcgac gcgggccagc accagggcac cggcacacat agtgcacggt
4199461 tcgacggtga ccgccaaggt ggtcccctcc agccgccacc cgtcgccgag cacaccggcc
4199521 gccaaccgca tcgccaggat ttccgcgtgc gcggtgggat cgccgagcgc ctcgcgggca
4199581 ttcaccgccc gggcgagttc ggttccgtcg gcgccgacga ccaccgcgcc caccggcacg
4199641 tcgcgcggac ccgccgtcgc cgcgaccgcc aacgccgcac ggatcagatc ttcgtcagtg
4199701 gtcaccgccc gcgcttgcgg tcaccgacct aggcggtcga tcaccgccga cagctggtca
4199761 gcgaagccca tttcgcgggc gatgcggccc agctgttcgt cggcgtaaag gtcggtctcg
4199821 tcgaggatga ctcccagaac cgcctcgggc aggccgatgt cggacagcag gcccaggtcg
4199881 ccttcctcga acggatcggc atcctcgagg tcttcgggat cgatctcggc gtccagattg
4199941 tccaggacct ccgcggcgat gtcgtagtcc agcgcggcgg tggcgtcgga cagcaacagc
4200001 cgagttcccg agggcgccgg gcgcacaatg acgaaaaatt cgtcgtcgac gtcgagtagc
4200061 ccgaagacgg ctcccgcgct acgcagctca cgcagttccg tctcggcagc ccgcagactg
4200121 gtcaacgctt tggggcccat cggagagcag cgccagcggc cctcttcacg cacaaccgca
4200181 acaccgaaac cgtccggtgt gtccgcggcc ggtctttgca tggaggcccg ttgtgctccc
4200241 atgggcgcct acggtagtcg ctgaccaggc ctcctgacca gatggtgctc agacagcgga
4200301 gatctggtcg cccctcaggg cgccgccacg ggctacctat gccaaccttg gactgtgact
4200361 cggactgtcg cggcgccacc ggtgtgcgtg cttgggctgg gactcatcgg cggttccatc
4200421 atgcgggccg ccgcagcggc gggccgtgaa gtctttggct acaaccggtc ggtggagggt
4200481 gcccacggcg cccgctccga cgggtttgat gccataaccg atctcaacca aacgctaacc
4200541 cgggccgccg ctaccgaggc gttgatcgtg ctggccgttc cgatgccggc cttgccaggc
4200601 atgctcgccc atattcgcaa atcggcacct ggctgtccgt tgaccgacgt caccagcgtc
4200661 aaatgcgcgg ttctcgacga ggtcacggcg gctggtctgc aggcgcgcta cgtcggcggt
4200721 cacccgatga cgggcaccgc gcactcgggt tggaccgccg gtcacggcgg cttgttcaac
4200781 agagccccct gggtggtcag cgtcgatgac catgtcgacc ccacggtgtg gtcgatggtg
4200841 atgacgctgg cgctggactg cggggcgatg gtggtgcccg ccaaatccga cgagcacgac
4200901 gccgccgctg ctgccgtctc gcacctgcca cacctgctcg ctgaggcgct cgccgtcact
4200961 gcggccgagg taccacttgc cttcgcgttg gctgcagggt ctttccgcga tgccacccgg
4201021 gtggcagcca ccgctcctga cctagtgcgg gcaatgtgtg aagctaacac cggccaactg
4201081 gcgccggccg cggaccggat catcgacctg ctgagccgtg cgcgtgattc gctgcaatcc
4201141 cacggttcga tagccgacct cgccgacgcg ggccacgccg cacgcacacg ctatgacagc
4201201 ttcccgcgct ccgacatcgt caccgtcgtt attggcgcgg acaaatggcg cgagcaactg
4201261 gccgccgcgg ggcgggcggg cggggtgatt acatccgctc tgccaagcct ggatagtcca
4201321 caatgaaccc gtcggagtcg acggtcacgg tggtgtcagc caccggtgag cgcagcttga
4201381 tcccatccag acgtccttcg ctggtatagc tcacggtggc cgcatcgacg ctcatctcgg
4201441 gcacgtttac atagaccacc ggcagcgcga tcgattccgc tcgttcgtgc agcccaaggc
4201501 gacgaatcgg caacgcattg aagaatggac tgaacaccaa atcgatgtcc aatgcaccgt
4201561 tgtatgctgc gcgccgttca ccctggtggt cagtcaccaa ccacatgttc tcctcgtcgc
4201621 gggcgatggc gagctggcgt tcccgctcgg ctagtgtgac cgtcagcccg aaccgtttgg
4201681 tggcaccggt ttcgtcggtc tgcagatcgt agtgcgcgcc aaacgccgga ttattcgcgg
4201741 tagccgcggc cacaatgcgg ccgttcgccc taatccgctt gccggacaac tggactcgta
4201801 ccgattccat gcgcgagatg tcctgcgcac gccaggtcaa catggccggc cagacgcgcg
4201861 gagtcagatc agaggggact gcgttcacac tgtctaccgt agggcgtgtc caccgcctgc
4201921 ggcaggtttg tcgacaaccg cggcgagctt gcgcatcctc ccggtgcccg gcaccgatac
4201981 ccaccccgcc aacgccagca gtccgtcgag ggtcaacgcc aacgcggcca ccatcatcgc
4202041 accgaccaga gcgatgtgga atcgacgctc cttgatcccg tcgatcaagt agccacccag
4202101 ccccccgaga ctggcgtagg cggccaccgt cgcggtggcg accacttgca gcgtcgcgct
4202161 gcgtagtccg ccgagcatca gcggtagtgc attgggtacc tcgacgcgca gcagcacctg
4202221 ggactcggtc atgcccatcg cccgggcggc atcgaccacc agcggatcaa cactggcaat
4202281 gccggcgtac gtgctggcca gcaaagacgg gatacccaac agcatcagcg ccaccagcgg
4202341 cggccccaat cccagcccga atagcagcac ccctagcagc agaacaccca acgtgggcaa
4202401 agcgcgcaaa ccattgaccg cacccaccac cagcagcgtc ccgcgaccgg tgtgcccgat
4202461 aagcagcccg actggcacgg cgatcagtgc tgaagcggcc accgccaccg cggtgtattc
4202521 caggtgctca cacgtgcgga ctgccaagcc gactggaccg gtccagttac tggcggttag
4202581 caggtaggac agcgcctgct gcaggaaatt catcgcgctc cgcccgtgat cggggccgcg
4202641 acctggcggc gccgacgggc tgcccgcggc gcccgttccc atggcgtggc cagccgaccg
4202701 gcgaggttga tcaccacgtc gacgacaatc gccagcagga acatcgctac gacgccggca
4202761 acgatctggt cactcttgtt ggtctgatac cccgcggtga accaggttcc caggcccccg
4202821 attcctatca ccgaacccac ggacaccatc gcgatgttgg taaccgcgac cacccgcagc
4202881 ccggctacca gcacggggat agacagcggc agttcgactt tcaacatctg agcgatccgc
4202941 gaatagccga tggcggtggc cgcgtcatgc acctgcgccg gcaccgcgtc cagcgcttcg
4203001 agcaccgccc gcaccagcag ggccgtggtg taggccgcca acgccacaat gacattggcc
4203061 tcgtcgagga tccgggttcc gatgatcagc ggcaacacca cgaatagcgc tagcgacggg
4203121 atggtgaata taacgctggc ggtcgccgtc gtcagccggc gaagcagcgg cgcgcgctgc
4203181 accagcaggc ccaacggcac cgcgctcatc agcccgatca gcaccggcag caacgagagg
4203241 cgcagatgga cgacggtcag cgcccaggcc gctcccgggt gggtcatcag gtagtgcatg
4203301 gcttagctcc gccgccggcc ttcttgcctt tttggaactc ggccagcacg tcggcggcca
4203361 gtatcccgcc gatgaccttg ccaccgccgt caacggcgac accgaccccc gacggcgagg
4203421 acaaggcggc gtccagcgcc tggctgaggt taccgttcgg gcggaacacc gaaccgccga
4203481 cggtcatggc atccgacaat gccgcgccgc cgcggtgacg ccgccggcca tcggcgtcga
4203541 tccagcccaa cggcgcaccc gcaccgtcga ccaccagcac ccagccgtca cgaacttgcc
4203601 tgtcccgggc atcggaaagg ccgttcaccg agacttgctc gatgtcgcgc acaggtagtc
4203661 cggccgcgtc gaacagctgc agccaccgat agccgcgacc gagaccgatg aacttcgaca
4203721 cgaagtcatt cgccggactg gataacagcc gggcagtttc gtcgtactgc gcaagcgcgc
4203781 cgcccggggc gaacaccgcc accagatcgg cgagcttcaa cgcctcgtcg atgtcgtgcg
4203841 tcacgaagac aatggtcttg tgcaactcgg cttgcagacg aagtatttcg ttctgtagct
4203901 cgtggcgaac caccgggtcg acggccgaga acggctcgtc catcaacaag atcggcggat
4203961 cggccgcgag tgcccgtgcc acgccgaccc gttgctgttc gccgcccgag agctgggccg
4204021 ggtagcgggt ggcgaccttg gggtccagcc cgacacgctc aagcacctca taaccggctt
4204081 tgcgggctgc ccggcgcggc tgacccttca gcaccggcac cgttgcgacg ttgtcgatga
4204141 cccgttgatg aggcatcagc cccgcgttct ggatgacata gccaattccc aggcgcagct
4204201 tcaccgcatt gaccgtcgac acgtcggtac cgtcgacagt gatggtgccc gaggtcggat
4204261 ccaccattcg gttgatcatt cgcagcgccg tcgtcttgcc gcagccggag gggccgacga
4204321 agacggtcag catgccgtta gggacttcca gcgtcagccg gtctacggcg gtggcaccgt
4204381 gtgcgtacac cttgctgaca tcgtcaaagc agatcaacgt ggtgcctact gccgcactgg
4204441 atgatcgaaa ccgttgtccc gcacccattt ccgcgcggcc tggtcggggt ccaccccgga
4204501 gttgccggac accgctgcat tgagctcggc caggccggca gtggtcagct ttgccgacac
4204561 cgcgtccagc acatctttga ggtgatccga cttctttcgc gaattcacaa gcggcacaat
4204621 gtttccggct aggaagttat gttcgggatc ttccagcacc accaggtggt tttgcgggat
4204681 agccgcagag gtgctgaaga ggttggcggc tgtggccgtt ccctccacca gtgctcgcac
4204741 ggtcaccgca ccgccgccgt cgttgatggt cacgaagttg cccggcgcga tgtcgagtga
4204801 gtatttgtgc cgcagcccgg gcaacccgga cggccgggtc tgaaaggccg acggcgccgc
4204861 gaacttcaca tccgcggaat gcggggccag gtcggcgatc gttttcaggt tccaccgggc
4204921 ggcggtagcg gcggtgacgg tgacggtgtc agtgtcagag gccggcgacg gcgtcaggat
4204981 cgacagatcg ccgggaagtc gcttgtagag ctccaactca acggcatcga gcatggtcac
4205041 cgtggcgtcg ggttgaaagt acagcagcaa gttgccgata tactccggca ccaggtcgat
4205101 ggaatgatct ttgagcgcca ggatatacgt ctctcgactg ccaattccca accgccgccc
4205161 cacgtcgaaa ccgttggcct gcaacacttg tgcgtagatt tcggcgatca cctgcgattc
4205221 cggaaaatca ccggacccga cgacgatgga cttcacactg ccggtcgctg acccgagcgg
4205281 atcagcattg gcgcaggacg caaccaggca caccgtcgcg agccacacag ccgcagcgac
4205341 agttgcgcga cgtaggcgtc gcagcatcct catgcagttg acactatcgt cagcggcggc
4205401 gccgtgcttc cacaactcgg catgtactgg gatttttccg gcgtggtttg gtttcattct
4205461 gtgtgggata ggacaaaaat ggtgtcatga ccagcaatcc ctcttcctcg gctgatcaac
4205521 cactcagcgg tacaacggtg cctggctcgg tgcccggtaa ggcaccggaa gagccacccg
4205581 tcaagttcac ccgcgccgcc gccgtatggt cggcgctgat cgtcggcttt ctgatcctca
4205641 tcctgttgct gatattcatc gcccagaaca ccgcctcggc ccaatttgcg ttcttcggct
4205701 ggcgctggag cctgccacta ggggtggcta tcttgctggc ggccgtgggc ggcgggctga
4205761 tcaccgtctt cgccggcacc gcgcggatcc ttcagttgcg acgtgcggcc aaaaagaccc
4205821 acgcggccgc ccttcgctaa ctgggcatcc ccgacgcggg attacccgct cttcttggca
4205881 atctctgcca gaccgcgagc gatcagcggc gcaacaacgt caggcaccga ctcagccgcg
4205941 gtgtccttcc cctcggcctg ctcggacatg cgtcggcggt agtcgatgcc ggcggcgatg
4206001 atggcgagct tgaaataggc caaggccatg tagaactccc agtggcctag cggctgcccg
4206061 gagacgagtg aataccgatc ggccagctcg tcggctgctg gcagcagcgg cgaagtccac
4206121 gctgcctgcg catgcacaat taagtccagc gcggggtcgc ggtatacgca catcagggcc
4206181 gcgtcggaca gcggatcccc cagggtggag agctcccagt ccaccaccgc gcgaacatgg
4206241 catgggtcat cggtgtccaa gatcgtgttg tcgatccggt agtcgccgtg cacgatcgat
4206301 gtgcggctct gttgtggaat ggcttgctgc agggctaaat gcagtcgcga aatgtcggcg
4206361 tcgcggtggt cgtcgggcag ccgcaccagc tcccattgtg acccccaccg gcgcacctgc
4206421 cgttccagat agccgtcggg tttgccgaaa tcgctcagtc cgacggcctt cgggtcgatg
4206481 ctatgcaagt cgacgagtac ccggatcaag gcgtcgacac agccctcgat gaccgaacgg
4206541 ctgccgagcg cttcgagttc ggcgcgccgg cgcaccactt gcccggcaac gaattcgaca
4206601 acctggaacg gcgcgcccag caccgagtcg tcctggcaca gcgagatcgt gcgcgccacc
4206661 ggaaccggtg tgtctcccag cgcggcgacc accctgtact cgcgggccat gtcgtgcgcc
4206721 gacggtgtca gcccgtgcag gggcggacgg cgcaccaacc agctcgacgc gtcatcatag
4206781 acccggaagg tcagattgga gcgtccaccg gagatcagct cgccacgcaa ctcgccgtcg
4206841 cgcccgatcc ccagcgaacg cagataccgg tccagcgcgc ccagatcgag cccgtcgagt
4206901 cggtcaaccg aagtcaccga acttgtttac cactcgcgca atgcccggct ttagctcagg
4206961 ccgccttcga ctcggcgccg agcggtaccg ccgaactacg gcgtcacgat gttgaaggcc
4207021 gaatcgggcc ggtcgaggac gctcaagaat gtctgcagca ccgtccggtc gccgaacacc
4207081 tcgaaaccgg gtgagctgat atcgcccagc gccgcggcga ccaaccgaac cttgtcgccc
4207141 accgtcaccg tcgcgttcgc cgtcgccgga tcggcgggaa gcttgcgatg tatcaacacg
4207201 ccgttgcgca gcgtgagccg atagttgaca tccggctcgg tgaaggtgaa atcgatggcc
4207261 aggtcgaggt cccatgcgcg tgggccattg atgctgatcg ccaggacgtc aaagatttgg
4207321 tccggcgtca gctgggcgaa aaacgtgggc gccgggactt gcccggagct gcccgggttc
4207381 ccgtcgcgca gctcggcggc cccggtcaga aagaaattgc gccaggtcgc acactccgcg
4207441 ccgtaggcca gctgctccag ggtgtcggca tagagcccgc gggccgcagc gtgctcgctg
4207501 tcggcgaaca ccgcatggtc gagaagcgtt gccgcccaac ggaaatcacc tgcgtcgaag
4207561 gcttcgcggg ccagctccag cactcggtcg atgccaccca acgcgtcgac ataacgcggc
4207621 gccagcgcct cgggcggatg cggccacaac cagcccgggt taccgtcaaa ccagcccatg
4207681 taacgctgat agatcgcctt cacgttatgg ctgaccgacc cgtagtagcc gtgggtgtgc
4207741 catgcccgct gcagcgccgg tggcagctgg aacatctcgg cgatctccac accggtgtag
4207801 ccctggttca gcagccgcag cgtctgatcg tgcagatatg aatacatgtc gcgctgttgc
4207861 gacaagaact cgacgatctt ctcgcgtccc cacgtcggcc agtggtgcga ggcgaacacc
4207921 acgtcggttc ggtcggcaaa ggtgtcaatc gcctcggtga gatagcccga ccaggcgcgc
4207981 ggatcgcgca ccaaggcgcc gcgcagggtc agcaggttgt gcaggttatg cgtggcgttt
4208041 tcggccatgc acaacgcgcg gaagcgcggg aaatagaagt gcatctccgc aggggcctcg
4208101 gtgcccgggg ccatctggaa ctcgatctcc accccgtcga tggtgtgggt ctccccggtc
4208161 tcggtgatgt cgaccgtcgg cacgacgagc gaaacctcac cggtcgacag tgtctgcccg
4208221 aggccgcagc cgacgtgccc ccggagaccg cgcgccaaca cggtgccgta catgtagccc
4208281 gcacggcgca tcatcgccga gccggcgtag atgttttcct gcacggcgtg cgcggtgaac
4208341 ccctccggcg ccagcaccgc cacctttccc gcgtccacgt cggcctgggt ggtgacgccg
4208401 agcaccccac cgaaatgatc gacatggctg tgggtgtaga tgaccgcgac cacggggcgg
4208461 tcggctccgc ggtgggcgcg atacaagtcc agcgcggcgg cggccacctc ggtggacacc
4208521 aacgggtcga tgacgatcag cccagtgtca ccctcaacga agctgatatt ggagatatcg
4208581 aatccgcgga cctgatagat gcccggcacc acctggtaga ggccctgttt cgcggtcagc
4208641 tgggattgcc gccacaggct gggatgcacc gatgtcggcg cggcaccgtc gagaaacgag
4208701 tacgcgtcgt tgtcccacac cacgcgacca tcggcagcct tgatcacaca cggggacagc
4208761 gcggcaatga atccgcgatc ggcgtcgtcg aaatccgttg tgtcatgcaa cggtaacgag
4208821 tgttcaccgt gtgccgcctg gatgacggca gtgggaggtt tgtgttccat cggcactaca
4208881 ttgccactac tacggtgcac gccggtagat gccgttggcg aaccacgcta ccgaccagaa
4208941 agagagaatt ttccgccgca cctagacctc gggccctgct aacgcgcata ctgccgaagc
4209001 ggtcctcaat gccgatggac cgctacgaca ggcaaaggag cacagggtga agcgtggact
4209061 gacggtcgcg gtagccggag ccgccattct ggtcgcaggt ctttccggat gttcaagcaa
4209121 caagtcgact acaggaagcg gtgagaccac gaccgcggca ggcacgacgg caagccccgg
4209181 cgccgcctcc gggccgaagg tcgtcatcga cggtaaggac cagaacgtca ccggctccgt
4209241 ggtgtgcaca accgcggccg gcaatgtcaa catcgcgatc ggcggggcgg cgaccggcat
4209301 tgccgccgtg ctcaccgacg gcaaccctcc ggaggtgaag tccgttgggc tcggtaacgt
4209361 caacggcgtc acgctgggat acacgtcggg caccggacag ggtaacgcct cggcaaccaa
4209421 ggacggcagc cactacaaga tcactgggac cgctaccggg gtcgacatgg ccaacccgat
4209481 gtcaccggtg aacaagtcgt tcgaaatcga ggtgacctgt tcctaaccta aagcgtgtcg
4209541 atgcgggctg tgaacagcgc gtcggagccg ggcagtcagg cctagcgcgg cgacgattcg
4209601 agcggttgcc atccgtcaag tggcaaccgc accgcaaact cggtatatcc gggtgagcta
4209661 ctcacggtga tcgttccgtt gtgcgccttg accacagcgg agacgatcgc caggccgagc
4209721 ccggtgctac cggcttggcg ggaccgtgac gtatcgccgc gggcgaaccg ctcgaaaacc
4209781 tcggactgca gcgcggccgg aatacccggc ccattgtcga tcacctgcag cacgacgtgc
4209841 gtcggcccgg tgctcaagcg cgtcgtcacg atcgtgccgg gaccggtgtg cacgcgggcg
4209901 ttggccagca ggttggtcac cacctggtgc aaccgtgccg catcacccgg gatgaccacc
4209961 ggttcggggg gcaggtcgag cgcccactgg tgatctggtc cggcaacatg agcgtcgctg
4210021 accgcgtcaa ccgcaagccg cgacatgtcc accggtccgc gttccagcgg ccgccccgag
4210081 tccagacgcg ccagcagcag caggtcctcg acgagacgtg ttatccgctc ggtctccgat
4210141 gccacccggc tcatcgcgtg tgcgacggcc tcgggatcgt cccctatccg ctgcgtcaat
4210201 tccgtgtaac cacggatcgc cgcaagggga gttcgcagtt catgactggc atcggcaacg
4210261 aactggcgca cacaggtttc actggcctgc cgcgccgaca gtgcggcagc gatgtggtcg
4210321 agcatccggt tgagcgccga cccgagttgc cccacctcgg tggaggggtt tgcgtcaggt
4210381 tcgggcaccc ggaccggtag cttgacctcg ccgcgatcca acggtaggtc gacgacttcg
4210441 ctcgcggttt gcgcgacgcg ccgcaacggc gccagcgccc gcttgatgat gacgattccg
4210501 gcggtcgtcg cggcgaccaa cgcaatcacc gtgacgattc cgaaaatgat cagcatctgc
4210561 aacatcgtgg cgtcgacgtt gcccatcgac aggccggtga cgatgacgtc gtgcccgttt
4210621 cggctcggag cggccagcac acggtaccgg cccagaccgt cgagatccag ggtcagcggt
4210681 gtgcggctgc cggcgatccg ttccagctgg gaccggccgg ttgacgtcaa cgccgcccgc
4210741 gaaccactgc cggtcagata tccggcggcg accgtcgtgc cgtcgctgac caccgccgcc
4210801 accatcccgg ccggctggcc cggagcatcg agaaacctcg gaccggggcc cgaccggatg
4210861 tagttgtgcg tctcgtgccg ccagggcgga cggggcattt tctccggata catcaacacc
4210921 gagcggtacg acgttccgcc gagttggttg tcaagttgtg ccaccagatg acgacgcagc
4210981 gccatttcgg ttgccgcggt gattcccaca cacaccacgg cgaggacgac aacctgtccg
4211041 accaggagcc gcagccgaag cgaccaaatt cgcggactgc tagcgggccg gcttgagcac
4211101 atagccggcg ccgcgcagcg tgtgaatcat gggttcgcga ccgttgtcga tctttttgcg
4211161 caggtacgag atgtacagct ccacgatatt ggaccggccg ccgaagtcgt aactccagac
4211221 gcggtccaga atctgggctt tgctcagcac ccgcttggag ttgtgcatca tgaaccgcag
4211281 cagctcgaac tcggtggacg tcaacgacac cggttcgccg gcgcgcatca cctcgtggct
4211341 gtcttcgtcc agcaccaagt ctccgaccac tagctgggca ccgctgtcga ctgtcgtcac
4211401 ccccgtgcga cgcagtaacg cccgcagccg aagcacgacc tcctcgatgc taaacggctt
4211461 ggtgacgtag tcgtcgcccc ccgcggtcaa cccagctata cgatcttcca ccgcgtcctt
4211521 ggccgtcagc agtagaaccg gcaggcctgg attctcgctg cgcaacttgt gcagcacgtc
4211581 aagaccgctc atgtcaggca acatcacgtc gagcacaacc acatcgggcc gctggcggcg
4211641 ggccgccgca atcgccgacg atccgtcacc ggcggtggtg atgttccaac cttcataccg
4211701 caatgccatg gacaccatct cggccagaac gggttcgtcg tcgaccacca gcacagtgac
4211761 cggttggcca tcggcgcgcc gcattacgac acgctcaacc gagatgcggt gctgcgtcac
4211821 agcgtcaagt atccgcacac ggctgagcag acgccatgcg gatcctatgt gcgcgctatg
4211881 aaacccgatt tggggcacgt tcggagcctg ccagcgggcc ggatccgggc ggtaccccac
4211941 tcacgtcggc gcgcatgttg gtaccagtag cggctgctgg cgaccgggct gctgaagcaa
4212001 atcccgctgc cacgcttgag gcagcgtccc ggaccaacgc caattggtcg ctctccgtcg
4212061 ccgttgtgga agtcgccgac ccggacagtt cgatcagaca tagccaagga tcggtagcat
4212121 gacgatacgc attccgatag cggggaattg aggtgccgtg acagacactt tgttcgcaga
4212181 tgtctccgaa tatcaagtgc ccgtgaataa ctcgtatccc taccgagtgc tgtcgatccg
4212241 cgtctgcgac ggcacctatc gggatcgtaa tttcgcgcac aactaccgat ggatgcgctc
4212301 ggcattcgac agcgggcgac tcacattcgg aatcgtctac acctacgccc gtccgaattg
4212361 gtgggccaat gccaacaccg tgcgctcgat gatcgacgca gcgggcggct tgcatccccg
4212421 ggtcgcgctg atgctggatg tcgaatcagg cgggaacccg cccggtgacg ggtcgagctg
4212481 gatcaaccgg ctgtactgga acctggcaga ctacgccggc tcgcccgtgc gaatcatcgg
4212541 ttatgccaac gcctacgact tcttcaacat gtggcgtgtt cgcccggcgg gcctgcgcgt
4212601 cattggcgcg ggttatggtt ccaatccgaa ccttcccgga caagtggcgc accagtacac
4212661 cgacggcagt gggtatagcc ccaatcttcc acagggcgct ccaccgttcg gtcgatgcga
4212721 tatgaactct gccaacggac taacaccgca acagtttgcc gccgcatgcg gcgtcacaac
4212781 gaccggagga ccgctgatgg cactcaccga cgaagaacaa accgaactac tgaccaaagt
4212841 ccgcgagata tgggaccaac tgcgcgggcc caacggcgcc gggtggcctc agctcggaca
4212901 gaacgaacag ggccaggacc tcactccggt tgacgcgata gcggtgatca agaacgacgt
4212961 ggcggccatg ctcgcggaat agcccgcgat ctccgtcagc tcgtggcccg ctgcgcggat
4213021 acgaaaaggt ttggcgggat tgagtcttcg ccactgtgag ggatgctgcg gccataccga
4213081 gccagcagct cgggcaacgt tgccgtcgac acgtcccagc cacgttcacg cagccactcg
4213141 gcgaccgcgg tgcgctgctc tgcataccag aggtcatcga catctgatat ctcagtttcg
4213201 accagcttgg ctgccgcggc ccgcatccgc cgcatgtccg cacgctggcg tcgcattcgc
4213261 tcagggtcga gaaaaccggc gccggggacg ttggacgcca accaactgcc cggcctgctg
4213321 agcgcatcga tacgctcgaa caacagatcc tgagcccgcg ccggcaggta ccgcaccaac
4213381 ccttcggcta accacgcaca cggcttcgat gggtcaaatc cggctttctg cagtgccttt
4213441 ggccagtcct gacgaaggtc tatgggaacg ttcaccagct gcgaagccgg ctgcgcgcca
4213501 tgctggcgca acgtggctga tttgaattcc agcaccttgg gctggtccag ctcgtacacc
4213561 acggtgccgt ccggccaggg cagccgccag gcacgcgagt ccaggcccga ggcgaggatc
4213621 actacttgcc tcaccccagc gtcggcggta gccaggaaat actcgtcgaa aaacgcggtc
4213681 cgggcggcca tgaaatcgat catctgctgt atcggcgccc gcaggtccgg gtcgaggtcg
4213741 gtcgcaccgg ccagcaacgt gcgattcgtg tacatgctcc atatcccgtc gccggccgcg
4213801 tccacaaaga tccgcgcgaa cggatcgttg atcaatgggt tgtcgctctc ggtctcggcc
4213861 gcacgcgccg ccgccacacc cagtgcggtg gcgcccacgc tctcggtaat ggcccaggaa
4213921 tcgttgtcgg tccgcggcac agttaatcct cccccaggcc ggaaacgtca gttttgcaaa
4213981 ctattcttcc agccgccgag gggcccgcgc gctcgtcaag agtgtcctac gctttctccc
4214041 agatggtcta caggttgcag aggagcgcga tggggtccac gccgccacgt acgccgcagg
4214101 aggtattcgc ccaccacggc caggcgctcg ccgcgggcga cctcgatgag atcgtcgccg
4214161 actacgccga cgactccttt gtcatcactc cggccggtat cgcgcgcggc aaggaaggta
4214221 ttcgccaact gttcgtcaag ttgctcgacg acataccaaa cgcactgtgg gacttaaaga
4214281 cccaaatctt cgagggcgac atactgttcc tggagtggac cgcgaattcc gcggtcagcc
4214341 gagtcgacga cggagtcgat actttcgtat tccgagacgg cacgatctgg gcgcataccg
4214401 tccggtacac cccgcacccc aagacctgac gtttcgagca ggtggcggat gtggacctcg
4214461 aggcggtcgc ctattaccga tcagaccgag gcactgttgt ctgacgcggg cggatacccc
4214521 cagggggcgc gttcctcgcc gcgcacgaag tcggtaggtt gcagccgcac tttgcggagg
4214581 aaccgcctgc tgatctgccg gataggatga gcccgtgacg acgctgaagg agcttggagc
4214641 acgggtcgcc gctctggaag cgaaccaggc cgactatcga gccgtcctcg cggccgtcaa
4214701 cccgccgggc gccaaccagc gagaaatcgc gacgaccgtc cgggaacaca ccggacgact
4214761 ggaccgcgtg acgaccaaag tcggccagct cgcggccaag tccgacgaca ccaatgcgcg
4214821 ggtgcggtct ctggaagagg gacaggccga gatcaaggac cttctgctcc gcgccctcga
4214881 caagtgattc tccgaatggc tgcgcgattt tttgagcccg gcatcgaacg gtgatctgtg
4214941 gtcggtgaat ccgcgacacg ccgtggtttc gggtcgtgcc ggatggcgtc aaatggccag
4215001 ctcagaacac ctttcgagac cacgattttc gagaccacga tcaggtgctg ttgcaggctc
4215061 tcctaaagcc gtagggcgtg tttgaaccgc accatgatgg ggtgcgcgga catcggttgg
4215121 cgatacgggc tcgaggttgc agatcctgtc cgcgctcgtg gccggcaccc gagcgaccct
4215181 gtcgaagacc gcgccttgat tacctggcgg tgagcgcgag ccgcctgacc agggccgcga
4215241 agcacagcgg cgccagcagc caggtcagct gcatggccgc tgtcaccggg tgaccacgaa
4215301 accagaacat caccgggttg aaccacaggt cgtcgacgta ggaccaggtc ccggcgagga
4215361 tcgccgacaa ctccacggcc agggccgtga gctgtcccca gagcacctgg acggtcaggc
4215421 cgagggcgcc cgcgggctcg cccgtgagcg ctcgcgccag cagccagccc atggtcagga
4215481 ggggaccatc ccacacggag tgggcgagca ggaacaccac ggtggggagc gggagcggcg
4215541 tggcccactc gatgatcggg gtgttggtcc aagcgctgag cccgaacacc ggcagctccc
4215601 agaccagacc gatgagcgtg ccgagcaaca gcatccgcgc gagctcgggt cgagtccttc
4215661 gagcgcgcag catgagcacc acgaccgcga gcgcgacgag caggtcggct acgtagtagc
4215721 catgggcgag gggatcgtta tccataagcg tgttctgttg tatgccacta agcatcgtat
4215781 ttgcctccgc gaaccttggt gagcaacagt gacgaacagt gacggcgagc cgccagttga
4215841 cccgcacgtg ggcacaacgg cgagcttccc gcaccgatgg ctacgaaccc cggccacgca
4215901 acgctatgcg gtcgccagcc agctgggcgc gcaggatccg ttggatcgcc ccagcggtac
4215961 ggtccgggtt ctcggggcgc agcgccaccg ccaactccag cacctcgacc ggggtgcgca
4216021 gcgtgcactg gcacgggttt gggcaccaag gcgtcgaacc caccggcgcg ccagtcccta
4216081 attcctaatc cagcggtcga tggtatgccg gctgatccga accttccgcc cgaacgggtc
4216141 ggtgtgctca cgggaggcca gctcgcgcac catctttccc cgctccttgg tggaatgcgc
4216201 tgcatcggcg gcctcccgga tcaactgata ccgaaacaat ccgatcgccc tcgcccgctc
4216261 cgcgcgcacc tcgccttatc atcgccgacc gccaccggcc gctcctttcc gtttggtgtc
4216321 ccgtgaacac acgacagcgc acaggattac ggcccaatcg gcggttaggg cagggtcgac
4216381 tcgtgttgca cccactcgcc gggtcacccc ggcgccacca gccgcccacc cgataccgcc
4216441 accgccgtct cggccagcga caccgtggac agcgcgaact ggcactcgat cacggtcacg
4216501 accgcggcga tcaccgtcac cgcataggcg aacaccccga cggccgcatc cggcatcacc
4216561 ggatccggat ccaccgcgcg caacatgacg gtgaacaccg accgaaccgc ctcggcacgc
4216621 tcggcaaagc gacgcagcca accccgcacc gtctcggccg ggcgagccaa atccgcggcg
4216681 atgcggcgga acccgacctg gctcaaggcc ttctccgccg gcgcgggcac agctccacca
4216741 cgtatgtgcg ctcgcagccc gacatgctgg ccgacggcgc gcagagttgg gcacgagttg
4216801 tgacaatccg tgacagcttt cccggcgcct gataccaacg gaacgcgttt gcgctagtaa
4216861 agagcgcgcc cgaagagatt cgaactccca accttctgat ccgtagtcag atgctctatc
4216921 cgttgagcta cgggcgcttg tcttcagttg tgtcccctaa aggactgcgg aggcgagagg
4216981 atttgaacct ccggtcccct tgaaggggga caactcatta gcagtgagcc ccattcggcc
4217041 gctctggcac gcctccatgg acttcccgag agtacccgga ctccccgagc cgccggaggc
4217101 ctagcgtaca cagccgccac atatgctgtc gacgtgaccg cccgcctgcg acccgagctg
4217161 gctgggctgc cggtttatgt gcccggcaaa acggtgccgg gcgccatcaa gctggccagc
4217221 aacgaaaccg tgttcggccc gctgcccagc gtccgtgccg ccatcgaccg ggctaccgac
4217281 acggtcaacc gctaccccga caacggctgc gtgcagctca aggccgcgct ggcccggcat
4217341 cttggcccgg acttcgctcc cgagcacgtc gccgtcggtt gcggctcggt cagcctctgc
4217401 cagcaactcg ttcaggtcac cgcctcggtt ggtgacgaag tggtcttcgg ctggcgcagc
4217461 tttgagctct atccaccaca ggtccgggtc gccggcgcta tccccatcca ggtgccgttg
4217521 accgaccaca cgttcgacct ctacgccatg ctcgccacgg tcaccgaccg cacccggctg
4217581 atcttcgtgt gcaaccccaa caatccgacc tccaccgtcg tcggtccgga cgcgctggcc
4217641 cgcttcgtcg aggcggttcc ggcgcacatc ctgatcgcca tcgacgaggc gtatgtggag
4217701 tacatccggg acggcatgcg gcccgacagc ttaggcctgg ttcgcgcaca caacaatgtc
4217761 gttgtgctgc gtacgttttc gaaagcgtac ggcctggcgg ggttgcggat cggctacgcg
4217821 atcggccacc ccgacgtcat aaccgcgctg gacaaggtct acgtgccatt taccgtgtcg
4217881 agtatcgggc aggccgcggc catcgcgtcc ctggacgccg ccgacgagct gctggcccgt
4217941 accgacaccg tggttgccga gcgcgcccgc gtcagcgccg agttgcgtgc tgccgggttc
4218001 acgctgccgc catcgcaggc caactttgtc tggcttccgc tgggatcccg cacccaagac
4218061 ttcgtggagc aggccgccga tgcacgcatc gtggtccgcc cgtacggcac ggatggcgtt
4218121 cgggtcaccg tcgccgcacc agaggagaac gacgcgttcc tgcggttcgc ccgccgctgg
4218181 cggagcgacc aatgagcgtg gcccgtaaga aaattcgacg cccacgctcg agcgtcacgg
4218241 ctatctggcc gggttgcggc cggtgaacgc gatcagccgc tccagcgccc cgccatcttc
4218301 cggcacgtcg accggttcat tgaaaccggc cacactacgt tcctccggct tgatgagctt
4218361 tcgtgccagc tctaggacgt attcggccaa cgaatcggca gccttcagct cactcccgac
4218421 ggcgaccgcg taatcccagg cgtgcaccag aaattcgacc gagaagaccg agacggcaac
4218481 cttggccgac atcgagccgg gacccagcga tacgtctcct tccagaccgt gacggtgcca
4218541 ggcgtccagg gccgaacggg cggcgccgct caccaggcgc tccacagagt caatgtccgc
4218601 acgcagtgag aattccgcgc cgaccatgcc gccgaggacc atgattgagt tgagcaaatg
4218661 ctcggttagt tttttcacgt cgtaccccgg gcacggtgtc tgcttggcct tgtcctggcg
4218721 gccgatggtg tgcagcactt gctgcagcac ctgcagcgcg gcttccgcgc acgccagctc
4218781 gtcggtcggt ggggaatctg gtccgggtcg cgattcaggc ggcatactgg ccacgctacg
4218841 gtctgggcat gggcgaaacc tacgaatccg tcaccgtcga aaccaaggac caggtcgcgc
4218901 aggtgacgct gatcgggccg ggcaagggca acgcgatggg gcccgcattc tggtcggaga
4218961 tgcccgaggt gttccatgcc ctggacgccg accgtgaggt gcgggccatc gtcatcaccg
4219021 gatcgggcaa gaacttcagc tacggcctgg acgtaccggc catgggcgga atgttcgccc
4219081 cgttgatcgc cgacggcgcg ctggcccgcc cacgcacgga cttccacacc gaaatactgc
4219141 gcatgcagaa ggcgatcaac gccgtcgccg actgccgcac ccccacgatc gcggccgtcc
4219201 agggttggtg catcggcggc gccgtcgacc tgatctccgc ggtcgacatc cggtatgcca
4219261 gcgccgacgc gaagttctcg gtgcgcgagg tcaagctagc gattgttgcc gacatgggca
4219321 gcctggcgcg ccttccacta atcctgagcg acggccatct acgagaactc gcgctgaccg
4219381 gcaaaaatat cgacgcggcc cgcgccgaga agatcggcct ggtcaacgac gtctacgatg
4219441 acgccgacca gacgctggcc gcggcccacg cgactgccgc cgagatcgcc gccaacccac
4219501 ctttggcggt ctacggcatc aaggacgttc tcgaccaaca acgcacgtcc gccgtctcgg
4219561 agaacctgcg ctatgtcgcc gcctggaacg ccgcgtttct gccgtccaag gacctcaccg
4219621 aaggtatttc cgcgacgttc gccaagcgcc cgccccagtt caccggcgag tagacccggc
4219681 gaccatgcgc gctggcgacg gcaagatccg tgtcccggcc gacctagacg ccgtcacggc
4219741 aaccggcgaa gaggaccact ccgaaatcga cggtgcggcc gtcgaccgga tctggcgggc
4219801 cgcacgccat tggtatcggg ccggtatgca tcccgcgatc cagttgtgca ttcggcacca
4219861 tgggcgggtc gtgctcaacc gcgcgatcgg gcacggctgg ggcaacgccc ccaccgatga
4219921 ggccgatgcc gagaagatcc cggtgacgac tgacaccccg ttctgcgtgt actcggcggc
4219981 caaggcgatc acggcgaccg ttgtacacat gctcgtcgag cgcggacact tcgcgctcga
4220041 cgaccgcgtc tgcgagtacc tgccctccta caccagtcat ggcaagcacc gcaccacgat
4220101 ccggcacgtg ctgacccaca gcgcaggcgt cccgtttccc accgggcccc gacccgacgt
4220161 cagacgcgcg gacgaccatg aatacgcggt ggaaaggctc ggcgaactac ggccgctata
4220221 tcggcccgga ctggtacaca tctaccacgc gctgacctgg ggtccgttga tgcgtgagat
4220281 cgtctacgcg gccaccggca aggaaatccg cgagatcctg gccaccgaga tcctcgaccc
4220341 gctgggcttt cggtggacca acttcggcgt cgccgagcgc gatgtgccgc tggtcgcgcc
4220401 cagtcacgcc accgggcggc agctgccgcc ggtgatcgcc gcggtgttcc gcaaggcgat
4220461 cggcggaacc gtgcacgaga tcatccccta tacgaacacc ccgttcttcc tcagcaccat
4220521 cctcccgtcg tccaacactg tgtcaacggc caacgagctg tcccgcttta tggaaatcct
4220581 gcgccgcggt ggcgaactcg acggtgttcg tgtactgagt cccgagacgc tgcgcggcgc
4220641 ggtgacggaa tgccggcgct tgcgaccgga cttcgccacc gggctgatgc cgcttcgctg
4220701 gggcaccggg ttcatgctgg ggtccgccaa gtacgggccg ttcgggcgca acgcgccggc
4220761 ggcattcggc catctcggtc tggtcaacat tgcggtttgg gccgaccccg aacgagctct
4220821 gtcgggcggt ttgatcagta gcggcaaacc cggtagggac cccgaggctg ggcgctacgg
4220881 cgccctgctg aacgccatta ccgccgaaat accacgggca tcgtcgggct gatctgccca
4220941 cgagcacgcc acgccgccct aaccgagccg gacggctttg tcgtgccggt cacatgtcgg
4221001 cctgttgcct tatgtcaaga tgcgccgccg tacgcgcgca ttatcaacga gtcaacgtgg
4221061 tcggtgcaga cctgctatac tcgaacgtat gttcgagata tcgttgtcgg acccggtgga
4221121 gctgcgcgat gccgacgatg ccgcgctgct tgccgcaatc gaggactgcg cgcgtgccga
4221181 ggtggccgcc ggcgcccgcc gcctgtcagc gatcgccgaa ctcaccagcc ggcgcaccgg
4221241 caatgaccag cgggccgact gggcgtgcga cggctgggac tgcgcggccg ccgaggtggc
4221301 cgccgcactg accgtaagcc accgtaaggc ctccgggcag atgcatctga gcctcaccct
4221361 aaaccgactg ccccaggtgg cggcgttgtt tttggccggg cagctcagcg cgcggctggt
4221421 gtcgatcatc gcctggcgca cctacctggt tcgcgacccc gaagcgctga gtctgctcga
4221481 tgccgccctc gccaaacacg ccacagcgtg gggtccgctg tcggccccca aactggaaaa
4221541 ggctatcgac tcctggattg atcggtacga tcccgccgca ctgcgacgca cccgtatctc
4221601 ggcccgcagc cgcgacctgt gcatcggtga tcccgacgaa gatgccggca ccgccgcact
4221661 atggggccgg ttgtttgcca ccgacgccgc catgctggat aagcgcctca cccagctggc
4221721 ccacggcgtc tgcgacgacg atccccgaac catcgcccag cggcgcgccg atgcgctggg
4221781 cgcgctggcc gccggcgctg atcggcttac ctgcggctgc ggtaattccg actgcccatc
4221841 cagtgccggc aaccaccggc aggcaaccgg tgtggtcatc cacgtcgtcg ccgacgcggc
4221901 agcactaggc gctgcacctg acccacgcct atccggcccg gaacccgcgt tggcacccga
4221961 agcacccgcc accccggcgg tcaagccgcc ggccgcgctg atcagcggcg ggggtgtggt
4222021 gcccgcgcca ctgctggccg agctgatccg cggtggggcc gccctcagcc gcatgcgcca
4222081 tcccggcgat ctgcgatcgg agccgcacta ccggccgtcg gccaagctgg ccgaattcgt
4222141 ccggatccga gacatgacct gccgattccc cggctgcgac cagcccaccg aattctgcga
4222201 catcgaccac acactgccct acccactcgg gcccacccac ccgtccaacc tgaaatgcct
4222261 ctgccgcaaa caccaccttc tcaagacctt ctggaccggc tggcgtgatg tgcaactgcc
4222321 cgacggcacc atcatctgga ccgcgcccaa cggccacacc tacaccactc atcccgacag
4222381 ccgaatcttc ttacctagct ggcacaccac caccgccgca ctacccccag caccatcccc
4222441 gccagccatt ggtcccactc acaccctgct gatgccacga cggcgccgga cccgagcggc
4222501 cgagctggcc caccgcatta aacgcgaacg cgcccacgtc acccaacgca acaagccacc
4222561 cccaagcggc ggggatacag cggtggcgga gggatttgaa cccccggacg gtgttagccg
4222621 tctctcgctt tcaaggcgag tgcattaggc cgctctgcca cgccaccgct gataagggta
4222681 acgagccggt agcgtgacca tcatgcgtgc cgtcgtcgcc gaatcctcag atcgactggt
4222741 atggcaggaa gtccccgacg tgtcggctgg gccgggcgaa gtgctcatca aggttgccgc
4222801 ttccggtgtc aaccgcgccg acgtgctaca ggccgccggc aaatatccgc cgcccccggg
4222861 agtaagcgac atcatcggcc tagaggtgag cggcatcgtc gctgcggtcg gtcccggggt
4222921 taccgaatgg tctgccggac aagaggtttg cgccttgctt gccggcggcg gctatgccga
4222981 atacgttgcc gttccggccg accaggtgct gccgattccg ccgagcgtca acctggtcga
4223041 ctcagccgcc ctgcccgaag tggcgtgcac ggtgtggtcg aacctggtga tgaccgctca
4223101 tctgcggccg ggtcagctgg tgctgattca cggcggggcc agcggcatcg gcagccacgc
4223161 gatccaggtg gtccgcgccc tggcagcacg ggtggcgatc accgccggct caccggagaa
4223221 actggagctc tgtcgcgacc tgggcgccca aatcaccatc aactaccgcg acgaggattt
4223281 cgtcgcgcgg ctgaagcaag agaccgatgg tagcggcgct gacatcatcc tcgacatcat
4223341 gggagcgtcc tacctggacc gcaatatcga cgcgctggcc accgacggcc agctgatagt
4223401 cattggcatg cagggcgggg tgaaggccga gctcaacctg ggcaagctgc tcaccaagcg
4223461 ggcgcgcgtc atcggtacca cgctgcgggc ccggccggtc agcggcccgc acggcaaggc
4223521 ggccatcgcc caggcggtgg cggcctcggt ctggccgatg atcgccgcga accgggtccg
4223581 gcccgtcatc ggcacccggc tgcccatcca acaggcggca caagcgcatg aactgatgtt
4223641 gtcgggcaag acgttcggaa agattctgct gacggtatag gcgaacctcg cggccggatc
4223701 aacctagcga cgccagcgcg cgcaccagct ggtcgacttc ggccatcgtc gagtaatgcg
4223761 ccagcccgac ggtgaccgcg ccgccgacgt cgttgacgcc cagcacgtcg agcacgcgtg
4223821 agccggtgtt ggcgatcgcg agaattccgt tgtccgccag ccgctgcacc acgcggtcag
4223881 ccggcacctt gtggaccgcg aagctgacca ccggtatctg tgcttccggg cgaccgatca
4223941 gcatcaccaa tggcagcgag cgcaacgaca ccatcagata gtcgaagacc cggttcaggt
4224001 acgcgtcagc agattgcatc gacaccgcta gtcgttcgcg tctgctgccg cgagccgact
4224061 cgtcgagcgc cgccaggtac tcaatgctgg cgaccacacc agccagcaga ccaaactggt
4224121 gcacgccgat ctccaggcgc gccggcccgg tggcatacgg attggtcgaa accgatccga
4224181 aggaattcat cactgacggg tcacggaaaa ccatcgcccc aatcggcgga ccaccccagg
4224241 catgcgcatt caccgtcacc acgtcggcgt cggtttctct gatatcgagc aaccgatacg
4224301 gcgcggccgc ggaatggtcg accaccacca gtgcccccac gtcgtgcacc agtttggtca
4224361 tcgcccgcag atcggtgacc ccgcccagcg ttccggatgc ggagttgacg gcgaccagcc
4224421 tggttgactt gctgatcagg ctctcccact gccacgtcgg cagctcgccg gtctcgatgt
4224481 cgacctcggc ccacttaacc ttggcgccgt agcggtgcgc cgcccgcagc cacggagcga
4224541 tgttggcctc gtcgtcaaga cgactgacga tcacttcgta tcccagcccg gcgcgtgagg
4224601 acgacgcttc ggccagcaac gacagcagca ccgcccggtc ggcgcccagc accacgccgc
4224661 ccgggtcagc gttgaccaga tcggccaccg cttcacgggc ggcgtcgagt accgccgcgc
4224721 tacgccgcgc cgacgggtga gcacccactg tgctagcgcc cgaccggcgg aaggccgtcg
4224781 acacggtggt cgcgacggaa tcgggaatca gcattccggc cggtgcatcg aagtgcaccc
4224841 atccgtcacc cagcgatggg tgcaatccgc gcacccgggc gacgtcgtat gccatgccag
4224901 ccaccttaga actcgggtgt cctagacgtc ccagcccgcc cgggcttccc tgagccatgt
4224961 cacccggcca gccatactaa tcgagtgggc ctgtggttcg gtacgctaat cgctttgatt
4225021 ttgctgatag cgccgggggc aatggttgct cgcatcgccc agctgaggtg gccggtcgcc
4225081 atcgcggttg gcccggcgct gacatacggc gtggtggcac tcgcgatcat cccctatggc
4225141 gcgctcggaa ttccctggaa cggttggacc gcgctggccg ccttggcggt gacgtgcgct
4225201 gtagcgaccg gtttgcagct actgcttgcc cgttttcggg acctcgacgc cgaggcactt
4225261 gcggttagcc gctggcccgc ggttacggtc gccgccgggg tgctgctggg cgccctgttg
4225321 atcggatggg ccgcatatcg cggcataccg cactggcagt ccatccccag cacctgggac
4225381 gcggtctggc acgccaacac cgtacgtttc atcctggaca ccggccaggc gtcctcgact
4225441 cacatggggg agcttcgcaa cgtcgagacc catgccccgt tgtactaccc gtcggtgttc
4225501 cacgggctgg tcgcggtgtt ctgccagtta accggcgcgg cacccaccac cggctacaca
4225561 ctgagttcgc tggccgcctc ggtctggctg tttccggtca gtgcagccgt tctcacctgg
4225621 cgcgcggtgc gctcacaccc gggcgcgctg tggtcggcct cctgcgcctc ggcagagtgg
4225681 cgcgccgccg gagcggcggg caccgccgcg gcactctcgg cgtcgttcac cgcggtgccc
4225741 tacgtcgagt tcgataccgc cgctatgccc aacctggcgg cctacggcat cgcggtgccg
4225801 acgatggtgc tgatcacctc gacattgcgg caccgcgacc gcatcccggt ggccgtgcta
4225861 gcgctggtcg gcgtcttctc actgcacatt accggcggta tcgtcgtagc gctgttggtg
4225921 tcggcctggt ggcttttcga ggcactgcgg catcctgtgc gatcaaggct ggccgacctg
4225981 ttgacgctgg ccggcgtggc agcgatggcc gggttggtca tgttgccgca gttcttgagc
4226041 gtcaggcagc aggaagacat catcgccgga cacgcttttc ccacctatct cagcaagaag
4226101 cgtgggctgt tcgacgctgt tttccagcac tcccgccatc tcaacgactt cccggtccag
4226161 tacgcgctca ttgtgttggc cgccatcggc gggctcattc tgctggtcaa gaagatctgg
4226221 tggccgctgg cggtttggct gctgttgatt gtgatgaacg tcgacgcggg aacaccgttg
4226281 ggcggaccta tcggaggggt ggccggcgca ctcggcgagt tcttctatca cgatccgcgc
4226341 cgcatcgcgg cggccacaac cctgctgttg atgctgatgg caggtgtggc gctgttcgcg
4226401 acagtcatgt tgctagtggc cgcggcgaaa cgactgaccg accgtttcag accccagccg
4226461 gtgtctgtct gggcatcggc gaccgcgaca ctactgatcg gagccactct ggtcagtgcg
4226521 tggcattact ttccccggca ccgatttctg ttcggcgaca agtacgactc ggtgatgatc
4226581 gaccagaaag atctcgacgc catggcatac ctggcgagtt tgcccggcgc acgcgacacg
4226641 ttgattggca acgccaacac ggacggcacc gcgtggatgt atgccgtggc cggcctacac
4226701 ccgctgtgga cccactacga ctacccgctg caacagggcc cgggctatca ccggttcatc
4226761 ttctgggcct atggccgcaa cggggagagc gatcctcggg tactcgaggc catccaagtc
4226821 ctccgtatcc gctatatcct gaccagcact ccgacggtgc gggggtttgc cgtgccggac
4226881 ggactagtgt cgttagagac atcgaggtcg tgggcgaaga tctacgacaa cggcgaggcc
4226941 cgaatctacg aatggcgcgg cactgccgca gcaacacact cctagaaggt gcgtaagagg
4227001 atggtgattg gattgagtac cggcagcgac gacgacgacg tcgaggtcat cggcggcgtc
4227061 gacccgcggc tgatagcggt gcaggagaac gactccgacg agtcgtcgct gaccgacctg
4227121 gtcgagcagc ccgccaaggt gatgcgcatc ggcaccatga tcaagcaact gctcgaggag
4227181 gttcgcgccg ccccactcga cgaagccagc cgcaatcggc tacgcgatat ccacgccacc
4227241 agcatccgcg aactcgaaga tggtctggcc ccggaactgc gcgaggagct cgaccggctt
4227301 accctgccgt tcaacgagga cgccgtgccc tcggacgccg agttgcgcat tgcccaggca
4227361 cagctggtcg gctggctgga agggctgttc cacggcatcc aaaccgcgct atttgctcag
4227421 caaatggcgg cgcgcgcgca gctgcaacaa atgcgccagg gtgcgctgcc gcccggggtc
4227481 ggcaagtcgg gccagcacgg ccacggcacc ggacaatacc tgtaagccgt gtcggatccg
4227541 caccatcccc atatccagac gcacaacgcg tgggtggagt tccctatctt cgacgccaag
4227601 tcacgttcgc tgaagaaggc ggtcctgggt aaagcgggcg gcaccatcgg gcgcaacaac
4227661 tccaacgtcg tcgtcatcga agcgttgcgc gacatcacca tggagctgaa cctgggtgac
4227721 cgggtcggtc tggtcggaca caacggagcc ggcaaatcga cgctgctacg cctgctttcg
4227781 ggcatctacg agcccacccg cggctgggcg aaggtcaccg gaagggtggc gccggtcttc
4227841 gatctgggca tcggcatgga ccccgagatc tccggctacg agaacatcat cattcgtggg
4227901 ctgtttctgg gacagacccg caaacagatg caggcgaaag tggatgagat cgccgaattc
4227961 accgaattgg gcgagtacct ttcgatgccg ctgcgcacct attccaccgg gatgcgagtc
4228021 cgcctggcga tgggcgtggt caccagcatc gacccagaga tcctgttgct cgacgaaggc
4228081 atcggcgccg tggacgccga cttcctgagg aaggcccagt cccggctgca gaatttggtc
4228141 gaacgttccg ggatcctggt tttcgcaagc cattccaacg agtttttggc tcgactatgc
4228201 aagaccgcga tatggattga ccatggcgtc atcaggctcg ccggtggtat cgaagaggtg
4228261 gtacgggcct acgagggtga ggacgccgcc cggcacgtgc gcgaagtact ggccgagacc
4228321 caggccgaca gacagaacgt ccagggatga ctgaatcggt cttcgccgtt gtggtaaccc
4228381 accggcgccc cgacgagctg gccaagtcgc tggatgtgct gaccgcccag acccggttac
4228441 cggaccacct gatcgtggtc gataacgacg gttgcggcga cagcccggtc cgcgagcttg
4228501 tcgcgggaca accgatcgcc accacgtatt tggggtcacg ccgaaacctg ggcggtgccg
4228561 gcggtttcgc gctgggcatg ctgcacgcgc tggcacaggg cgccgattgg gtgtggctgg
4228621 ccgacgacga cgggcacgcg caagatgcta gggtactggc aaccctgctg gcgtgcgccg
4228681 agaagtacag cctcgccgag gtgtcaccga tggtgtgcaa catagacgac ccgacgcggc
4228741 tggcgtttcc gttgcggcgt ggcctggtat ggcgcaggcg cgcaagtgaa ttgcgcaccg
4228801 aggcgggcca agagctgctg cctgggatcg catcactgtt caacggcgca ctgtttcggg
4228861 catccaccct agcggcgatc ggcgtgcctg acctgcggct gttcatccgc ggcgacgagg
4228921 tggagatgca ccgccggctg atccggtccg gtctaccgtt cggaacctgt ctggacgcgg
4228981 cctacctgca cccctgcgga tcagacgaat tcaagccgat cctttgtggc cgcatgcacg
4229041 cccaatatcc cgacgatccc gggaagcggt ttttcaccta ccgcaaccgt ggctatgtat
4229101 tgtcgcaacc cggcctgcgc aaactattgg cccaggaatg gctgcggttc ggctggttct
4229161 tcctggtgac ccgccgcgac cctaaaggcc tgtgggagtg gattcggttg cgccgcctgg
4229221 gccgtcggga gaagtttggc aagcctggag gatctgcatg acattcatgg atgctcaagc
4229281 tagcttccag acacagtcgc ggacactggc ccgcgtccga ggcgatctgg tcgacgggtt
4229341 ccgccgccac gagctgtggc tgcacctggg ctggcaggac atcaagcagc ggtaccgccg
4229401 ctcggtgctg gggccgttct ggatcaccat cgccaccgga acgaccgccg tcgcgatggg
4229461 cggcctgtat tccaagctgt ttcggctcga gctgtctgag cacctgccct acgtcacgct
4229521 cgggctgatc gtctggaacc tgatcaacgc cgccatcctg gacggcgcag aggttttcgt
4229581 cgccaacgaa ggtctgatca aacagctgcc ggcaccgttg agcgtgcacg tctatcggtt
4229641 ggtgtggcgg cagatgatct tcttcgccca caacatcgtc atctacttcg tcatcgcgat
4229701 catctttcct aagccgtggt cgtgggcgga tctgtcgttt cttccggcgc tggcgctcat
4229761 tttcctcaat tgcgtttggg tgtcactgtg tttcggcatc ctggcgaccc gctaccgcga
4229821 catcggcccg ctgctgtttt ccgttgtgca gttgttgttc ttcatgacgc cgatcatctg
4229881 gaacgacgag accctgcgtc ggcagggcgc gggccgctgg tcgagcatcg tcgagctcaa
4229941 cccgctgctg cactatctgg acatcgtgcg ggcgccactg ttgggcgctc accaggagct
4230001 gcggcactgg ctggtggtgc tggtgttgac cgtcgtcggc tggatgctgg cggcgttcgc
4230061 gatgcggcag tatcgcgcgc gggtgcccta ctgggtgtag ggactattcc ggcggctata
4230121 gccgaccggc ttctttcacg cggcttgcgc gtgacgggcc gccgttgatc tcaagatcgg
4230181 ctggcaacgg ccgcgtacca gcggcagcat ggattaggtt caccgtttgc cgatgaggct
4230241 cagagggcgg gacggatgga aatacttgtc accgggggcg cgggcttcca gggaagccat
4230301 ctgaccgagt cactgctggc caatgggcat tgggtcactg tcctcgacaa gtcttcgagg
4230361 aatgcggttc gtaacatgca gggatttcgt tcgcatgacc gcgccgcgtt catatccggt
4230421 tcggtaaccg acggccagac gatcgaccgc gcggtgcggg accatcacgt cgtatttcac
4230481 ctggccgcgc atgtcaacgt ggaccagtcc ttgggcgacc cggagagctt tctcgaaacc
4230541 aatgtcatgg gaacctaccg cgtcctggaa gccgtccggc gctacaggaa ccgcttgata
4230601 tacgtatcga cgtgcgaagt ctacggcgac ggacacaatc tcaaggaagg cgaacgactt
4230661 gacgaacacg cggagctgaa gccgaacagt ccatatggcg cttccaaggc ggcggccgac
4230721 cgcttgtgct actcgtactt tcgctcctac ggactcgacg tcacgatcgt ccgtccgttc
4230781 aacatcttcg gcgtccgcca aaaggctggg cgattcggcg cgctgattcc gcggctggtc
4230841 cgccagggca tcaacggtga aggcctgaca atcttcggcg caggtagcgc aacccgggat
4230901 tacctgtatg tcagtgacat cgtgggcgcg tacaacctgg tattacgaac tccaaccctg
4230961 cgtggtcagg ccatcaattt tgccagcggg aaagataccc gggtgaggga catcgtcgag
4231021 tatgttgcgg acaagttcgg tgccaggatc gagcaccgcg acgctcgccc cggagaggtc
4231081 cagcgctttc ccgctgacat ttcgcttgcc aaaagcatcg ggttccagcc gcaagtcgaa
4231141 atttgggacg gcatcgatcg ctatatcaat tgggccaagg atcagcccca atacccatat
4231201 gagcaggacg ggtttagcgg ttccagcgtt ctctaataca cccgtcgccg ccatcgtctg
4231261 ccggtaaagt gggccgaaat ggcgcggaac taccagctgg aaggattacc tcccattcga
4231321 tggtgaccgt agcacgccga ccggtgtgcc cggtgacgct gacaccgggt gacccggcgc
4231381 tagcgtcggt gcgcgacctg gtcgacgcgt ggagcgcgca tgatgcgctg gcagagctgg
4231441 tcacgatgtt cggcggcgcg tttccgcaga cggaccatct ggaagcgcgg ctggcgagcc
4231501 tggacaagtt cagcacggca tgggactacc gggcgcgcgc acgtgcagca cgagcgctcc
4231561 acggcgaacc ggtgcggtgc caggactccg gcggtggggc gcgatggctg atcccccgcc
4231621 tggacttgcc ggccaagaag cgggacgcga tcgtcgggtt ggcgcagcag ctggggctca
4231681 ccttggaatc gaccccgcag ggaacaacct tcgaccacgt tctagtcatc ggcaccggac
4231741 gtcattccaa cctgatccgg gcccgctggg cccgggaatt ggcaaagggt cgccaggttg
4231801 gtcacatcgt gctcgccgcc gcatcgcgtc gattgctgcc ctccgaggat gacgcggtcg
4231861 cggtctgtgc gccgggcgca cgcaccgaat tcgagctatt agcggccgcg gcaagggacg
4231921 cattcggcct ggacgtccac ccagcggtgc ggtatgtgcg ccagcgggac gacaacccgc
4231981 accgggacag catggtgtgg cgcttcgccg ccgacaccaa tgacctaggc gttccgatca
4232041 ccctgctgga ggcgccatcg ccggagcccg acagcagccg cgccacctcg gccgacacct
4232101 tcacgtttac cgcacacacg ctgggtatgc aggactcaac gtgtctgttg gtgaccgggc
4232161 aaccgttcgt gccctaccag aacttcgacg cactgcgaac tctggcgctg cccttcggga
4232221 tacaggtgga gacagtgggc ttcggcatcg accgctacga cgggctgggt gagttggacc
4232281 aacaacaccc tgccaagctg ctgcaggagg tccgctcgac gatccgagcg gcccgagccc
4232341 tgctggaacg gatcgaggcc ggcgagcgca tggctaccga tcctcggcgg tgatggtgca
4232401 tggcgtggcc ggcgggtagc tgcccgatac ggctcgcaac cgtcccggtg gcggccacgg
4232461 ccgtagtccc atgttggcta ggtaccgcac cggattgaca tgcccgtcct gcgtgcggac
4232521 ctcgaaatgc agataaccat ctgccgattc gccttgcgca ccgatggtgc ccagttgcgc
4232581 tcccgcggcg attcgatcac caaggacaag gcggccctcg tccccgggcc gaaatacata
4232641 gacaacgtcg agctcgcagc gtgcgatcgt cagcgacacc aggccatcga cctcgtcgat
4232701 cgcgctgacg gccccggaag cgaccgcgta gacgggtgtt cccggatcgg tggcgaagtc
4232761 gacaccggga tggaaaccac ccgcgtgcgg accgtacccg cggccgatcg cgcgcggctc
4232821 ccggtcgatc ggcagccgcc cgcccggctc gagcggatcg aagtcgccgc ggatgcgccg
4232881 ccggtagtcg gctttgagca ggtcgacctc gtcgagtgcg tagccaaaca acaaagatcg
4232941 gtcgtaggcc accccgaagt tgaaccgata gtccggatcg agccgcagat agtgctccac
4233001 cctcaagatc cgttccgcca gcgtcgacca gccgctatgc accagccgaa cccccggaag
4233061 ctgtccgatg cgaccgtgat cggtgatgtt ggccggccaa tgcgggttgt gcatcagctt
4233121 gccgcctgcc cgcagacccg ggtaccagcg ccacaacggt ccacgtagcg cttcggcggt
4233181 tcccatcacc ggaatcaggt cgggatactc cggatcatcc cagcgtgaca ccatcggaca
4233241 catcagcgcc acgatgtcgt ccggtgtgcg ggctaacacc gcccgaagat cgatgtcggt
4233301 ctcgaccaac caatcggcat cgaccatcat cacccagtcc gggcggcaga agtccgccat
4233361 ccgatacagc agttccagcc cggcggactc aggaatcagc catggcgtgg gcggcagatc
4233421 tggtcgggcc cgcaccacgt tcgtcaccgc aggatggttc gccaggatct cggcggtgtc
4233481 atcggtgctg cggtcgtcga tcacgtagat gtcgtcgctg aacacggcca acgagtccaa
4233541 cgttgcggct agtgtccgcc cggcgttgtg cgcacgcgtc atcgccagaa tccgcatgcc
4233601 gcctctctat caccccagaa cacaggtcca gtagttgggt ctgtccgcca atccagcggg
4233661 aagggcgggc gccgcgggca gatcgtgggc ggccagcagc tgcgcggtgg tggtccccac
4233721 cgagcgccat ccgtggttgt ccaggtagcc ggacacctcg tggcgggggc cggcatagtt
4233781 gagtgcccag atgtccagat gaaagccatg ctctcgccag cctcgggtcg cggtgcggat
4233841 catctcttcc acccgagcgg aatcccgatc cgcagaaccg aggaaggcct cgagggccag
4233901 ccggctcccg ggcgcgctca agtcggtgac gtggtccagc agacgattct gcgcgtccgg
4233961 gggaaggtat ccgaacaaac cctcggcgat ccacgcggcc ggctcggccg catcgaagcc
4234021 gccgcggcgc agcgcatcgg gccaatcgtg acgcaggtcg gccggcacca tccgcagatc
4234081 cgcggtcggc tgggcaccca agccggcgag cgtttgagcc ttgaactcga gcacccgagg
4234141 ctgatcgacc tcgaacaccg tcgtatccgc cggccatggc agccggtacc cgcgtgcgtc
4234201 gagccccgac gccaggatca ccgcttgccg aacgccggcg gcggccgcgt ccaagaagaa
4234261 ctgatcgaag tagcgggtgc gcaccaccaa ctcggtcgtc attcgctgca agccccaggc
4234321 cgcgtcgggg tcgtccacat cggcagcatc cagttctccg gttgcccatc gggtgaggaa
4234381 ctcgacaccc acggcacgaa ccaacggttc ggcgaacggg tcgtcgatga ggggctgggc
4234441 cgccctggcc gccctggccc ttcccgcggc gaccagcgtg gcggtcgcgc cgacaccggt
4234501 ggctaggtcc cagctatcgt cgtcggtacg cgccacggat ccatcttcgg cccggtccgg
4234561 ccgccaacgc tccgctgtcg acccgaacaa ccggttacaa ctgcgtgacg aatatcgatg
4234621 acggctgcac cttaagggtg taacactgaa gcgccacgaa tccgatttat cgtcctgtgg
4234681 tgatcggtga aacggcaccc acagcacgct attaggtaaa cagctatccg ggcgcaggcg
4234741 acaacgcagt caccgaagcg ccgcgaaagg tcggcggacg tgagcgagaa agtcgagtca
4234801 aaggggctag cggatgcggc acgcgatcac ctcgcggctg agttggcccg gctgcggcag
4234861 cgacgcgatc ggctggaggt cgaggtcaag aacgaccggg gcatgatcgg cgatcacggc
4234921 gacgcggccg aggcgataca acgtgccgac gaactggcca tcctcggtga ccggatcaat
4234981 gaactggacc ggcggctgcg caccgggccc accccctgga gcgggtcgga aacgctgccc
4235041 ggcggcaccg aggtgacctt gcggttccct gacggtgaag tcgtcacgat gcatgtaatc
4235101 tccgtcgtcg aagagacgcc ggtgggccga gaagccgaaa ccctgacggc gcgcagccca
4235161 ctaggtcagg ccctggccgg tcaccaaccc ggcgacacgg tgacctactc gaccccgcag
4235221 ggtcctaatc aggtccagct gcttgctgtc aagctgccct cataattcgc acaccgcacc
4235281 aggctcgccg cccccattag acttcccccg atgatccgat cggagtctgg tgccgcgccg
4235341 ccacgccaac acctgcacct gtcggcacag gtaatgcggt tcgttgtcac cggcggcctc
4235401 gctgggatag ttgactttgg cctctacgtc gtgctgtaca aggtggcggg cctacaggtc
4235461 gacctgtcca aggccatcag cttcatcgtc ggcaccatca ccgcgtacct gatcaaccgc
4235521 cggtggacat tccaggccga gcccagcacg gcccgattcg tcgcggtcat gctcctctac
4235581 ggaatcacct tcgccgtgca ggtcggactc aaccacctct gcctcgcact cttgcactac
4235641 cgggcgtggg ccatccccgt cgcgtttgtg atcgcgcagg gcaccgccac ggtaatcaac
4235701 ttcatcgtgc agcgagccgt gatcttccgg atccgctgag ccggtcaggg tcgaatcggg
4235761 cgggtaccct ctttgacgat gttgagcgtg ggagctacca ctaccgccac ccggctgacc
4235821 gggtggggcc gcacagcgcc gtcggtggcg aatgtgcttc gcaccccaga tgccgagatg
4235881 atcgtcaagg cggtggctcg ggtcgccgag tcggggggcg gccggggtgc tatcgcgcgc
4235941 gggctgggcc gctcctatgg ggacaacgcc caaaacggcg gtgggttggt gatcgacatg
4236001 acgccgctga acactatcca ctccattgac gccgacacca agctggtcga catcgacgcc
4236061 ggggtcaacc tcgaccaact gatgaaagcc gccctgccgt tcgggctgtg ggtcccggtg
4236121 ctgccgggaa cccggcaggt caccgtcggc ggggcgatcg cctgcgatat ccacggcaag
4236181 aaccatcaca gcgctggcag cttcggtaac cacgtgcgca gcatggacct gctgaccgcc
4236241 gacggcgaga tccgtcatct cactccgacc ggcgaggacg ccgaactgtt ctgggccacc
4236301 gtcgggggca acggtctcac cggcatcatc atgcgggcca ccatcgagat gacgcccact
4236361 tcgacggcgt acttcatcgc cgacggcgac gtcaccgcca gcctcgacga gaccatcgcc
4236421 ctgcacagcg acggcagcga agcgcgctac acctattcca gtgcctggtt cgacgcgatc
4236481 agcgctcccc cgaagctggg ccgcgcggcg gtatcgcgtg gccgcctggc caccgtcgag
4236541 caattgcctg cgaaactgcg gagcgaacct ttgaaattcg atgcgccaca gctacttacg
4236601 ttgcccgacg tgtttcccaa cgggctggcc aacaaatata ccttcggccc gatcggcgaa
4236661 ctgtggtacc gcaaatccgg cacctatcgc ggcaaggtcc agaacctcac gcagttctac
4236721 catccgctgg acatgttcgg cgaatggaac cgcgcctacg gcccagcggg cttcctgcaa
4236781 tatcagttcg tgatccccac agaggcggtt gatgagttca agaagatcat cggcgttatt
4236841 caagcctcgg gtcactactc gtttctcaac gtgttcaagc tgttcggccc ccgcaaccag
4236901 gcgccgctca gcttccccat cccgggctgg aacatctgcg tcgacttccc catcaaggac
4236961 gggctgggga agttcgtcag cgaactcgac cgccgggtac tggaattcgg cggccggctc
4237021 tacaccgcca aagactcccg taccaccgcc gaaacctttc atgccatgta tccgcgcgtc
4237081 gacgaatgga tctccgtgcg ccgcaaggtc gatccgctgc gcgtattcgc ctccgacatg
4237141 gcccgacgct tggagctgct gtagatggtt cttgatgccg taggaaaccc ccagacggtg
4237201 ctgctgctcg gtggcacctc cgagatcggg ctcgccatct gcgagcgcta cctgcacaat
4237261 tcggcggccc gcatcgtgct ggcctgcctg cccgacgacc cacggcggga ggacgcggcc
4237321 gctgcgatga agcaggccgg cgcgcggtcg gtggagctga tcgactttga cgccctggat
4237381 accgacagcc acccgaagat gatcgaggcg gccttctccg gcggtgatgt ggacgtggct
4237441 atcgtcgcgt tcggcttgct cggcgacgcc gaagagctgt ggcagaacca gcgcaaggcg
4237501 gtgcagatcg ccgaaatcaa ctacaccgca gcggtttcgg tgggcgtgct gctggctgag
4237561 aagatgcgcg ctcagggctt cggtcagatc atcgcgatga gctcggccgc cggtgagcgg
4237621 gtgcgacggg cgaacttcgt ctacggctcc accaaggccg gtctggacgg gttttacctg
4237681 gggttgtcag aagcgctgcg cgagtacggt gttcgtgtgc tggtgatccg gcccggccag
4237741 gtgcgtaccc ggatgagcgc gcacctcaag gaagctccat tgaccgtcga caaggagtac
4237801 gtcgccaacc tcgcggtgac cgcgtccgca aaaggtaagg aattggtttg ggcgccagca
4237861 gcgttccgct acgtcatgat ggtgttgcgt cacatcccgc ggagcatctt ccgcaagctg
4237921 cccatctgag tatgccgagc agacgcaaaa gcccccaatt cgggcacgaa atgggggctt
4237981 ttacgtctgc tcgcgcccgg gaggtgctgg tcgctcttgg ccagctggca gcggcggtgg
4238041 tagtggccgt cggtgtcgcg gtggtgtccc tgctcgccat tgcgcgggtg gagtggcccg
4238101 ccttcccgtc gtccaaccag ctgcatgcgc tgaccaccgt cggccaggtc ggctgcctgg
4238161 ccgggctggt cggcatcggc tggttgtggc ggcacggtcg attccggcga ctggcccggc
4238221 tgggcgggct ggttttggta tccgcgttta ccgtcgtgac gctgggcatg ccgctgggcg
4238281 ccaccaagct gtatctgttc ggcatctctg tcgaccagca gttccgcacc gaatacctca
4238341 cccggctcac cgacaccgcc gccctgcgcg acatgaccta catcggactg ccaccgtttt
4238401 acccaccggg ctggttctgg atcggcggac gcgcggcggc gctgaccggg acgccggcct
4238461 gggagatgtt caagccgtgg gcgatcacct cgatggccat tgcggtggcc gtcgcgctgg
4238521 tgctgtggtg gcggatgatc cgcttcgaat acgccttgct ggtcaccgtc gccacagcgg
4238581 cggtgatgct ggcctacagc tcgccggagc cctacgccgc gatgatcacg gtgttgttgc
4238641 cgccgatgct cgtactgacc tggtcgggcc tgggcgcgcg cgaccgtcag ggctgggccg
4238701 cggtggtcgg tgccggcgtc ttcctgggct tcgcggccac ctggtacacc ctgttggtcg
4238761 cctacggcgc gttcacggtg gtgctgatgg cgctgctgct ggccgggtcg cggctgcaat
4238821 ccggaatcaa ggcggcggta gacccgctgt gccggcttgc cgtcgtcggc gcgatcgcgg
4238881 ccgccatcgg atccaccacc tggctgccct acctgctgcg ggcggcccgc gacccggtca
4238941 gcgacaccgg cagcgcccag cactacctac ccgcagacgg cgccgcactg accttcccca
4239001 tgctgcagtt ctccctgctg ggcgcgatct gtctgctggg cacgctgtgg ctggtgatgc
4239061 gcgcgcgatc atcggcgcca gccggcgccc tggccatcgg cgtgctggcc gtctacctgt
4239121 ggtccctgct gtcgatgctg gccacattgg cgcgcaccac actgctgtcg tttcgcctgc
4239181 agccgacgct gagcgtgctg ctggtggcgg ccggtgcgtt cggcttcgtc gaagcggtcc
4239241 aagcccttgg caaacggggt cgcggtgtca ttccgatggc cgccgccatc gggttggccg
4239301 gcgcgatcgc gttcagccag gacatccccg acgtgttgcg gccggacctg accatcgcct
4239361 acaccgacac cgacggctac ggccagcgcg gcgaccggcg accgcccggc tccgagaagt
4239421 actacccagc catcgatgcc gccatccggc gcgtcaccgg caagcgccgc gatcggaccg
4239481 tcgtgttgac cgccgactac agcttcctgt cgtactaccc ctactggggc tttcaggggt
4239541 tgacgccgca ctacgccaac ccgctggcac agttcgacaa gcgcgccaca cagatcgaca
4239601 gctggtcggg actctccacc gccgacgagt tcatcgccgc gctggacaag ctgccctggc
4239661 agccgccgac cgtcttcctc atgcgccacg gcgcacataa cagctacacc ctgcggctgg
4239721 cccaggacgt ctaccccaac cagcccaatg ttcgccgcta cacggtggac ctacggaccg
4239781 ccctcttcgc cgacccgcgt ttcgtcgtcg aggacattgg cccgttcgtg ctggccatcc
4239841 gcaagccgca ggagagcgcg tgatggctac cgaagccgcc ccaccccgta tcgccgtccg
4239901 gctaccatct acctccgtgc gcgacgcggg agcaaactac cggatcgccc ggtacgtcgc
4239961 tgtggtggcg ggtctgctag gcgctgtgct ggccatcgcc accccactgc tgccggtcaa
4240021 ccagaccacc gcgcaattga actggcccca aaacggcacg ttcgccagtg tcgaggcacc
4240081 gctgattggc tacgtggcca ccgacttgaa catcaccgtc ccctgccagg ccgccgccgg
4240141 actggccgga tcgcagaaca ccggcaagac ggtgttgttg tcaacggtgc ccaagcaggc
4240201 gcctaaggcc gtcgatcgcg ggctgctgct gcaacgggcc aacgacgacc tggtgcttgt
4240261 ggtgcgtaat gtcccgttgg tcaccgcccc gctgagtcag gtgctcggcc cgacctgtca
4240321 gcggttgaca ttcaccgcgc acgccgatcg ggtcgccgcc gaattcgtcg gactggtgca
4240381 gggacccaat gctgagcacc ccggtgcacc gctgcgcggt gagcgcagcg gctacgactt
4240441 ccgcccgcag atcgtcgggg tgttcaccga cctggccggg ccggcgccac cgggtctgag
4240501 cttctcggcg agcgtggata cccgctacag cagcagcccc acgccgctga agatggccgc
4240561 catgatcctc ggggtagcgc tcaccggcgc cgccctggtg gcgctgcaca tcctggacac
4240621 cgccgacggc atgcggcacc ggcggttcct gcccgcgcgc tggtggtcga ccggcggtct
4240681 ggacaccctg gttatcgccg tgctggtgtg gtggcatttc gtcggggcca acacctccga
4240741 cgacggctac atcctgacca tggcccgggt gtccgagcat gcgggctata tggccaacta
4240801 ctaccgctgg ttcggcacac ccgaggcgcc tttcggctgg tactacgacc tgctggcgct
4240861 gtgggctcat gtcagcacgg ccagtatctg gatgcgccta cccaccctgg cgatggcgct
4240921 cacctgctgg tgggtaatca gccgtgaggt cattccccgg ctggggcacg ccgtcaagac
4240981 gagccgggca gcggcgtgga cggcggcggg catgtttctg gctgtctggc tgccgctgga
4241041 caacggcctt cggcccgagc cgatcatcgc cctgggcatc ctgctgacct ggtgctcggt
4241101 ggagcgggcg gtggccacca gccggctgct gccggtggca atcgcctgca tcatcggtgc
4241161 cttgaccctg ttctccgggc cgacgggcat cgcctcgatc ggtgcgctgc tggtcgcgat
4241221 cgggccgcta cggaccatcc tgcaccggcg ttccaggcgg ttcggcgtgc taccactggt
4241281 ggcgccgatc ctggccgcgg ccaccgtcac cgcgatcccg atctttcgtg atcagacctt
4241341 cgcgggcgag atccaggcca acctcctcaa gcgtgccgta gggcccagcc tgaagtggtt
4241401 cgacgaacac atccgctacg agcggctgtt catggccagc cccgacggct cgatcgcccg
4241461 ccgcttcgcc gtgctggcct tggtgctggc gctcgcggta tcggtggcaa tgtcgttacg
4241521 taagggccgc attccaggta ccgctgctgg accgagccgc cgcatcatcg gcatcacgat
4241581 catttccttc ctcgcgatga tgttcacccc gacaaagtgg acccatcact tcggggtgtt
4241641 cgcggggttg gccgggtcgc tgggggcgct tgccgcggtc gcggtgacgg gcgctgcgat
4241701 gcgctcgcgg cggaaccgga ccgtgttcgc cgccgtggtg gtcttcgtgt tggccctgtc
4241761 gttcgccagt gtcaacggct ggtggtacgt gtccaacttc ggtgtgccat ggtcgaactc
4241821 gtttccgaag tggcgatggt cgcttaccac cgcactcctc gagctgacgg tgctggtgct
4241881 gctgctagcg gcatggttcc acttcgtcgc caacggtgac gggcgccgaa cagccaggcc
4241941 aacccggttt agggcacgac tagccggaat tgtccagtcc ccgttggcaa ttgccacgtg
4242001 gttgctggtg cttttcgagg tggtatcgct gacccaggcg atgatttccc agtacccggc
4242061 gtggtcggtt ggccggtcta acctacaggc tttggccggc aagacctgcg ggctggccga
4242121 agacgtgctg gtggagctgg atcccaacgc aggcatgctg gcgccggtga ccgcgccgtt
4242181 ggccgacgcc ctgggagccg gcctgtctga agccttcaca cccaacggca ttcccgccga
4242241 cgtcaccgcc gacccggtga tggaacgtcc aggggatcgc agtttcctca acgacgacgg
4242301 gctgatcacc ggcagcgaac ccggcaccga agggggcacc acggccgcac cgggaatcaa
4242361 cggctcccgc gcccggctgc cctacaacct ggacccggcc cgtacaccgg tgctgggcag
4242421 ctggcgagcc ggcgtgcagg tgcccgccat gctgcggtcg ggctggtacc ggctgcccac
4242481 caacgagcag cgggacaggg cgccgctgct ggtggtgacg gcggccgggc gattcgactc
4242541 ccgcgaggtc cggttgcagt gggccaccga cgagcaagcg gccgccggac accacggtgg
4242601 gtcgatggaa ttcgccgacg tcggtgccgc gccggcctgg cgcaacctgc gcgcaccact
4242661 gtccgccatc ccgagcaccg ccacccaggt ccggttggtc gccgacgacc aggatctggc
4242721 gccgcagcac tggatcgccc tcacaccacc gcggattccg cgggtgcgca cgctgcagaa
4242781 cgtggtgggc gcagcggatc cggtgttcct ggactggctg gtggggctgg cattcccctg
4242841 ccaacgcccg ttcggccacc aatacggcgt cgacgagaca cccaagtggc ggatcctgcc
4242901 ggaccggttc ggcgccgaag ccaactcacc ggtgatggat cacaatggcg gtggcccgct
4242961 gggcatcacc gagctgctga tgcgcgcaac cacggtggcc agctacctca aagacgactg
4243021 gtttagggac tggggcgcgt tacagcggtt gacgccttac taccccgacg cccagcccgc
4243081 tgatctgaac ctaggaacgg tgactcgcag cgggctgtgg agtccggcgc cgttgcgccg
4243141 cggctagaag tgccgtggcc accgactcgg cgacaacctc cgcggccccg catcctcacc
4243201 gcccttaacc gcgtcgccta ccatcgagcc tcgtgcccca cgacggtaat gagcgatctc
4243261 accggatcgc acgcctagca gccgtcgtct cgggaatcgc gggtctgctg ctgtgcggca
4243321 tcgttccgct gcttccggtg aaccaaacca ccgcgaccat cttctggccg cagggcagca
4243381 ccgccgacgg caacatcacc cagatcaccg cccctctggt atccggggcg ccacgcgcgc
4243441 tggacatctc gatcccctgc tcggccatcg ccacgctgcc cgccaacggc ggcctggtgc
4243501 tgtccacact gccggccggt ggcgtggata ccggtaaggc cgggctgttc gtccgcgcca
4243561 accaggacac ggtcgtcgtg gcgttccgcg actcggtggc cgcggtggcg gcccgctcca
4243621 cgatcgcagc gggaggctgt agcgcgctgc atatctgggc cgataccggc ggcgcgggcg
4243681 ctgattttat gggtataccc ggcggcgccg ggaccctgcc gccggagaag aagccacagg
4243741 ttggcggcat cttcaccgac ctgaaggtcg gagcgcagcc cgggctgtcg gcccgcgtcg
4243801 acatcgacac tcggtttatc acgacgcccg gcgcgctcaa gaaggccgtg atgctcctcg
4243861 gcgtgctggc ggtcctggta gccatggtgg ggctggccgc gctggaccgg ctcagcaggg
4243921 gccgcaccct gcgcgactgg ctgacccgat atcgcccgcg ggtgcgggtc ggattcgcca
4243981 gccggctcgc tgacgcagcg gtgatcgcga ccttgttgct ctggcatgtc atcggcgcca
4244041 cctcgtccga tgacggctac cttctgaccg tcgcccgggt cgccccgaag gccggctatg
4244101 tagccaacta ctaccggtat ttcggcacga cggaggcgcc gttcgactgg tatacatcgg
4244161 tgcttgccca gctggcggcg gtgagcaccg ccggcgtctg gatgcgcctg cccgccaccc
4244221 tggccggaat cgcctgctgg ctgatcgtca gccgtttcgt gctgcggcgg ctgggaccgg
4244281 gcccgggcgg gctggcgtcc aaccgggtcg ctgtgttcac cgctggtgcg gtgttcctgt
4244341 ccgcctggct gccgttcaac aacggcctgc gtcccgagcc gctgatcgcg ctgggtgtgc
4244401 tggtcacgtg ggtgttggtg gaacggtcga tcgcgctcgg acggctggcc ccggccgcgg
4244461 tagccatcat cgtggcgacg cttaccgcga cgctggcacc gcaggggttg atcgcgctgg
4244521 ccccgctgct gactggtgcg cgcgccatcg cccagaggat ccggcgccgc cgggcgaccg
4244581 atggactgct ggcgccgctg gcggtgctgg ccgcggcgtt gtcgctgatc accgtggtgg
4244641 tgtttcggga ccagacgctg gccacggtgg ccgaatcggc acgcatcaag tacaaggtcg
4244701 gcccgaccat cgcctggtac caggacttcc tgcgctacta cttccttacc gtggagagca
4244761 acgttgaggg gtcgatgtcc cgccggttcg cggtgctggt gttgctgttc tgcctgttcg
4244821 gggtgctgtt cgtgctgctg cggcgcggcc gggtggcggg gctggccagc ggcccggcct
4244881 ggcgactgat cggcactacg gcggtcggcc tgctgctgct cacgttcacg ccaaccaagt
4244941 gggccgtgca gttcggcgca ttcgccgggc tggccggggt gttgggtgcg gtcaccgcgt
4245001 tcacctttgc ccgcatcggt ctacatagtc gacgcaacct cacgctgtac gtgaccgcgt
4245061 tgctgttcgt gctggcgtgg gcaacctcgg gcatcaacgg gtggttctac gtcggcaact
4245121 acggggtgcc gtggtatgac atccagcccg tcatcgccag ccacccggtg acgtcgatgt
4245181 ttctgacgct gtcgatcctc accggattgc tggcagcctg gtatcacttc cggatggact
4245241 acgccgggca caccgaagtc aaagacaacc ggcgcaaccg catcttggcc tctacgccac
4245301 tgctggtggt cgcggtgatc atggtcgcag gcgaagtcgg ctcgatggcc aaggccgcgg
4245361 tgttccgtta cccgctttac accaccgcca aggccaacct gaccgcgctc agcaccgggc
4245421 tgtccagctg tgcgatggcc gacgacgtgc tggccgagcc cgaccccaat gccggcatgc
4245481 tgcaaccggt tccgggccag gcgttcggac cggacggacc gctgggcggt atcagtcccg
4245541 tcggcttcaa acccgagggc gtgggcgagg acctcaagtc cgacccggtg gtctccaaac
4245601 ccgggctggt caactccgat gcgtcgccca acaaacccaa cgccgccatc accgactccg
4245661 cgggcaccgc cggagggaag ggcccggtcg ggatcaacgg gtcgcacgcg gcgctgccgt
4245721 tcggattgga cccggcacgt accccggtga tgggcagcta cggggagaac aacctggccg
4245781 ccacggccac ctcggcctgg taccagttac cgccccgcag cccggaccgg ccgctggtgg
4245841 tggtttccgc ggccggcgcc atctggtcct acaaggagga cggcgatttc atctacggcc
4245901 agtccctgaa actgcagtgg ggcgtcaccg gcccggacgg ccgcatccag ccactggggc
4245961 aggtatttcc gatcgacatc ggaccgcaac ccgcgtggcg caatctgcgg tttccgctgg
4246021 cctgggcgcc gccggaggcc gacgtggcgc gcattgtcgc ctatgacccg aacctgagcc
4246081 ctgagcaatg gttcgccttc accccgcccc gggttccggt gctggaatct ctgcagcggt
4246141 tgatcgggtc agcgacaccg gtgttgatgg acatcgcgac cgcagccaac ttcccctgcc
4246201 agcgaccgtt ttccgagcat ctcggcattg ccgagcttcc gcagtaccgg atcctgccgg
4246261 accacaagca gacggcggcg tcgtcgaacc tatggcagtc cagctcgacc ggcggtccgt
4246321 tcctgttcac ccaggcgctg ctgcgcacct cgacgatcgc cacgtacctg cgtggggact
4246381 ggtatcgcga ctggggatcg gtggagcagt accaccggct ggtgccggcc gatcaggctc
4246441 cagacgccgt tgtcgaggag ggcgtgatca ctgtgcccgg ctggggtcgg ccaggaccga
4246501 tcagggcgct gccatgacac agtgcgcgag cagacgcaaa agcaccccaa atcgggcgat
4246561 tttgggggct tttgcgtctg ctcgcgggac gcgctgggtg gccaccatcg ccgggctgat
4246621 tggctttgtg ttgtcggtgg cgacgccgct gctgcccgtc gtgcagacca ccgcgatgct
4246681 cgactggcca cagcgggggc aactgggcag cgtgaccgcc ccgctgatct cgctgacgcc
4246741 ggtcgacttt accgccaccg tgccgtgcga cgtggtgcgc gccatgccac ccgcgggcgg
4246801 ggtggtgctg ggcaccgcac ccaagcaagg caaggacgcc aatttgcagg cgttgttcgt
4246861 cgtcgtcagc gcccagcgcg tggacgtcac cgaccgcaac gtggtgatct tgtccgtgcc
4246921 gcgcgagcag gtgacgtccc cgcagtgtca acgcatcgag gtcacctcta cccacgccgg
4246981 caccttcgcc aacttcgtcg ggctcaagga cccgtcgggc gcgccgctgc gcagcggctt
4247041 ccccgacccc aacctgcgcc cgcagattgt cggggtgttc accgacctga ccgggcccgc
4247101 gccgcccggg ctggcggtct cggcgaccat cgacacccgg ttctccaccc ggccgaccac
4247161 gctgaaactg ctggcgatca tcggggcgat cgtggccacc gtcgtcgcac tgatcgcgtt
4247221 gtggcgcctg gaccagttgg acgggcgggg ctcaattgcc cagctcctcc tcaggccgtt
4247281 ccggcctgca tcgtcgccgg gcggcatgcg ccggctgatt ccggcaagct ggcgcacctt
4247341 caccctgacc gacgccgtgg tgatattcgg cttcctgctc tggcatgtca tcggcgcgaa
4247401 ttcgtcggac gacggctaca tcctgggcat ggcccgagtc gccgaccacg ccggctacat
4247461 gtccaactat ttccgctggt tcggcagccc ggaggatccc ttcggctggt attacaacct
4247521 gctggcgctg atgacccatg tcagcgacgc cagtctgtgg atgcgcctgc cagacctggc
4247581 cgccgggcta gtgtgctggc tgctgctgtc gcgtgaggtg ctgccccgcc tcgggccggc
4247641 ggtggaggcc agcaaacccg cctactgggc ggcggccatg gtcttgctga ccgcgtggat
4247701 gccgttcaac aacggcctgc ggccggaggg catcatcgcg ctcggctcgc tggtcaccta
4247761 tgtgctgatc gagcggtcca tgcggtacag ccggctcaca ccggcggcgc tggccgtcgt
4247821 taccgccgca ttcacactgg gtgtgcagcc caccggcctg atcgcggtgg ccgcgctggt
4247881 ggccggcggc cgcccgatgc tgcggatctt ggtgcgccgt catcgcctgg tcggcacgtt
4247941 gccgttggtg tcgccgatgc tggccgccgg caccgtcatc ctgaccgtgg tgttcgccga
4248001 ccagaccctg tcaacggtgt tggaagccac cagggttcgc gccaaaatcg ggccgagcca
4248061 ggcgtggtat accgagaacc tgcgttacta ctacctcatc ctgcccaccg tcgacggttc
4248121 gctgtcgcgg cgcttcggct ttttgatcac cgcgctatgc ctgttcaccg cggtgttcat
4248181 catgttgcgg cgcaagcgaa ttcccagcgt ggcccgcgga ccggcgtggc ggctgatggg
4248241 cgtcatcttc ggcaccatgt tcttcctgat gttcacgccc accaagtggg tgcaccactt
4248301 cgggctgttc gccgccgtag gggcggcgat ggccgcgctg acgacggtgt tggtatcccc
4248361 atcggtgctg cgctggtcgc gcaaccggat ggcgttcctg gcggcgttat tcttcctgct
4248421 ggcgttgtgt tgggccacca ccaacggctg gtggtatgtc tccagctacg gtgtgccgtt
4248481 caacagcgcg atgccgaaga tcgacgggat cacagtcagc acaatctttt tcgccctgtt
4248541 tgcgatcgcc gccggctatg cggcctggct gcacttcgcg ccccgcggcg ccggcgaagg
4248601 gcggctgatc cgcgcgctga cgacagcccc ggtaccgatc gtggccggtt tcatggcggc
4248661 ggtgttcgtc gcgtccatgg tggccgggat cgtgcgacag tacccgacct actccaacgg
4248721 ctggtccaac gtgcgggcgt ttgtcggcgg ctgcggactg gccgacgacg tactcgtcga
4248781 gcctgatacc aatgcgggtt tcatgaagcc gctggacggc gattcgggtt cttggggccc
4248841 cttgggcccg ctgggtggag tcaacccggt cggcttcacg cccaacggcg taccggaaca
4248901 cacggtggcc gaggcgatcg tgatgaaacc caaccagccc ggcaccgact acgactggga
4248961 tgcgccgacc aagctgacga gtcctggcat caatggttct acggtgccgc tgccctatgg
4249021 gctcgatccc gcccgggtac cgttggcagg cacctacacc accggcgcac agcaacagag
4249081 cacactcgtc tcggcgtggt atctcctgcc taagccggac gacgggcatc cgctggtcgt
4249141 ggtgaccgcc gcgggcaaga tcgccggcaa cagcgtgctg cacgggtaca cccccgggca
4249201 gactgtggtg ctcgaatacg ccatgccggg acccggagcg ctggtacccg ccgggcggat
4249261 ggtgcccgac gacctatacg gagagcagcc caaggcgtgg cgcaacctgc gcttcgcccg
4249321 agcaaagatg cccgccgatg ccgtcgcggt ccgggtggtg gccgaggatc tgtcgctgac
4249381 accggaggac tggatcgcgg tgaccccgcc gcgggtaccg gacctgcgct cactgcagga
4249441 atatgtgggc tcgacgcagc cggtgctgct ggactgggcg gtcggtttgg ccttcccgtg
4249501 ccagcagccg atgctgcacg ccaatggcat cgccgaaatc ccgaagttcc gcatcacacc
4249561 ggactactcg gctaagaagc tggacaccga cacgtgggaa gacggcacta acggcggcct
4249621 gctcgggatc accgacctgt tgctgcgggc ccacgtcatg gccacctacc tgtcccgcga
4249681 ctgggcccgc gattggggtt ccctgcgcaa gttcgacacc ctggtcgatg cccctcccgc
4249741 ccagctcgag ttgggcaccg cgacccgcag cggcctgtgg tcaccgggca agatccgaat
4249801 tggtccatag cgtcaggctc cgcagtcgat agcggcacga tgttcgtcat tagacggccc
4249861 catcagttag gcctcctatg ctgctcggta tgcaccaggc cggccatgtt ggcacacacg
4249921 aacggcgcgc agccgcaacg aggcggtccg ccctgactgc ggcagggtta gccgtcgtcg
4249981 gcgcaggggt gttgggcgcg tcggcgtgca gtccacaaaa gtctcctcag ccatcatcac
4250041 cccggttgcc cgacaatgcg ctgatcacgc tcggggtggc cgccggcccg ccgcctacgc
4250101 ccagcagagt aggaatctcg tcggtgctga aaattggccg cgatctgtac gtgatcgatt
4250161 gcggcctggg ctcgctgaac gcattcacca acgcgggcct gcaattcgac gatctcaaag
4250221 ccatgtttat cacccacttg cacaccgacc acatcgtcga ctactacaac ttctttctct
4250281 ccggtggctt ccttgcccca cccggtcgag cgccggtcct ggtctatggt ccgggcccag
4250341 ctgggggttt gccgccaagt gaagtcggca acccgaatcc agccaccgtc aaccccgcca
4250401 acccgacacc gggccttgcc gcggccaccg aagcgctgca tcgagcgttc gcttacacca
4250461 gcaacatctt catccgcgac tacggcattg acaacgttgc ggacctggtt aaagtcacgg
4250521 agatcgggct accaccagga tcggactacc gcaacagagc gccaaagatg agcccgttct
4250581 cggtcgcatc ggacgacaac gtttccgtca ccgcaacgct ggtctcccac tacgacgtct
4250641 acccagcgtt cggattccgc ttcgatctga agaaatcggg tgtgtccgtt accttctcgg
4250701 gtgacaccac taagtccgac aacctgatta ccctcgctca aggcactgac attctggtcc
4250761 acgaggcggt gttcagcctc gatacggctt actttggcaa cgctttcccc ccgaactatc
4250821 tggtgaactc acacacctcc gcagagcagg tgggggaggt ggccgcagcg gccaagccca
4250881 aacaattgat cctgagccac tacgcccctg acgacctacc cgactcgcag tggctcgaca
4250941 agatcaagaa gaattactcg ggcatgacca ccatcgcgcg ggacggccag gtcttcgccc
4251001 tctgatccgt tagcggtagc gccccgttcg acgatcgctg cctagagcta gacatatata
4251061 aaacctatgc aatagggtcg cggcatgccc gagtacgacc tagaggccgt ggacaagctg
4251121 cccttctcga cccctgaaaa ggcgcagcgc taccaaacgg aaaactatcg cggggccatg
4251181 ggcctcaact ggtacctcac ggatccgacc ctgcagttca tcatggccta ttacctacga
4251241 cccgatgaat tggcgttcgc agaaccccat ctgacccgca ttggtgagct gacggggggg
4251301 ccagtgacgc gttgggccga ggaaaccgac cgcaaccccc cgcggctcga acgctacgac
4251361 cggtgggggc atgacatcag ccgggtagtg ctgccggaat cgttcatcca atccaagcgc
4251421 gccgtcatcg aggcgcgaca agccgtgcgc gacgacgcgg cacgggccgg cgtcaagccg
4251481 tcgctggcac tcttcgccgc cgactatctg ctcaaccagg ccgatatcgg tatggcttgc
4251541 gcgctcgcca ctggcggcaa catggtccgg tcgctggtga ctgcctacgc gccacccgat
4251601 gtgcgcgaat tcgtcctagg caaactcaat tccggcgagt gggacggcga ggccgcgcag
4251661 ctgctgacgg agcgtgcggg cggctccgat ctgggagctc tggagacgac ggccacccgc
4251721 agcggcgacg tgtggctgct gaacggcttc aagtggtttg cgtccaactg cgccggggag
4251781 gcgttcgtgg tgttggccaa gcccgagggg gcgcctgact cgactcgagg tgtggccacc
4251841 ttcctcgtgc tacggacgcg ccgtgacggt tcccgcaacg gcgtgcgtat ccgtcggctg
4251901 aaggacaagc tcggcacccg ctctgtcgcc tccggtgaaa tcgagttcgt cgacgccgaa
4251961 gcctttctgt tgtccggcga accgagcgct gacgcgggcc cgtccgacgg caagggactc
4252021 acccgcatga tggagctgac caacagattg cggttgggca ccgcctcgtt cgccctcggc
4252081 aacgcgcgcc gcgcgctggt cgaatcgctg tgctacgccg ggcagcggcg ggcattcggt
4252141 ggggcgctca tcgacaagcc gctgatgcgc cgcaagctgg ccgaaatggt cgttgatgtg
4252201 gaagccgcgc tggcgatggt gttcgacggc ttcggagcgg cgaaccaccg ccagcccaga
4252261 tgcctgccgc aacgtatcgc ggtgccggtc accaagctta agacttgccg gctcgggatc
4252321 accgtggcat cggatgcgat cgagatccac ggcggcaatg gctacatcga gacctggccg
4252381 gtggcccggt tgctgcgtga cgcgcaagtc aacacgatct gggagggccc cgacaacatc
4252441 ctgtgtctgg atgtgcggcg cgggatcgag cagacgcgcg ctcacgagac actgttggcg
4252501 cggctgcgcg atgcggtgtc ggtgtccgac gatgacgaca ccacgcggct ggtctcgcgc
4252561 cgcattgagg acctcgacgc ggcgatcacc gcttggacca aactcgacag gcagctggcc
4252621 gaggcgcggc tgttcccgct ggcccaattc atgggcgacg tctacgccgg cgcgttgctc
4252681 accgagcagg ccgcctggga acgggcaacc cgcggcaccg accgcaaggc actcgtcgcc
4252741 cgcctgtacg cgcgccggta tctcgccgac caaggcccgc tgcgcggtat cgacgcagat
4252801 tgcgatgagg cgctgcagcg tttcgacgaa ctcgtggcgg gcgcgttcac tgccgagcag
4252861 acgtaaaagc ccccaattcg tggctcttct gacacttccg tgggtgagtt tgtgtcctga
4252921 gtaggcgcac gtcgttgtgg cttaaggttt ctggcttgtc aaggatcaga aacacaagga
4252981 gccgacaacg acgtgcgcaa tgtgaggcta tttcgtgcgc tgctgggtgt cgacaagcgc
4253041 accgtgattg aggacatcga attcgaggag gatgacgccg gagacggtgc gcgggtgatc
4253101 gcccgggtgc ggccacgaag tgcagtgttg cgccgctgtg gtcgctgcgg tcgcaaggcg
4253161 tcctggtatg accgcggtgc gggcctgcgc caatggcgca gtctggattg gggcaccgtc
4253221 gaggtgttct tggaggccga ggcgccgcgg gtgaactgcc ccacccatgg gccgacggtg
4253281 gtggcggtgc cgtgggcgcg tcatcatgcc gggcacacgt atgctttcga tgacacggtg
4253341 gcctggctgg cggtggcgtg ttcgaagacc gcggtgtgcg agttgatgcg gatcgcctgg
4253401 cgcaccgtcg gggcgatcgt ggcccgggtc tgggccgaca ccgaaaagcg cattgaccgg
4253461 ttcgcgaact tgcgccgcat cggtatcgat gagatctcct acaagcgcca ccaccggtac
4253521 ctgacggtgg tcgtcgatca cgacagcggc cggttggtgt gggccgcccc gggccacgac
4253581 aaggccaccc tgggcttgtt cttcgatgcc ctgggcgctg agcgggccgc ccagattact
4253641 cacgtttcgg ccgatgccgc ggactggatc gctgacgtgg tcaccgagcg ctgcccggat
4253701 gcgattcaat gcgccgatcc gtttcatgtg gtggcctggg ccaccgaggc gctcgacgtc
4253761 gagcggcgcc gagcctggaa cgacgcacgg gcgatcgcgc gcaccgaacc caagtggggc
4253821 cggggccggc ccggtaagaa cgccgcacca cgtccgggcc gcgagcgggc acggcggctc
4253881 aagggcgccc gctacgcgct gtggaagaac cccgaggacc tcaccgaacg ccaaagcgcc
4253941 aaactggcct ggatcgccaa gaccgatccc cgtctgtatc gcgcctacct gctcaaagag
4254001 agcctgcggc atgtgttttc ggtcaagggc gaggaaggta aacaggccct ggaccggtgg
4254061 atctcctggg cccagcgctg tcgcatcccg gtattcgtcg agcttgccgc ccgcatcaaa
4254121 cgccaccggg tggccatcga cgccgccctc gaccacggcc tatcccaagg cctgatcgaa
4254181 tccaccaaca ccaagatccg cctactgacc cggatcgcgt tcggattccg ctcaccacaa
4254241 gccctcatcg ccctagccat gctcaccctc gccggccacc gccccaccct gccaggccga
4254301 cacaaccacc cacagatcag tcagtagagc ccaattcgta ccgaatttgg gggcttttac
4254361 gtctgctcgc gctacccagc tagaccggga tcaggccgtg cttgcggccc acccgccacc
4254421 acagctgctt gtcccgcagc aggtgcatcg acttgcgcaa cagcagccgg gtctcatgcg
4254481 ggtcgatgac ggcatcgatg aacccgcgct cggcggcgat ccacgggatc gccatgttga
4254541 ggttgtaatt ctcgacgaag ctcttccgga tcgcttgcgc ctccggcgca ttcgggtccg
4254601 ggaaacgctt catcagcaac tgcgcggccc cgtcggcgcc gatcaccgcg atgcgcgcgg
4254661 tgggccaggc gaagttcagg tcggcggtca gctgcttgga ccccatcacc gcgtaggcac
4254721 cgccgtagga cttgcggatg gtgatcgtca ccttcggcac atcagcctcg accaccgcgt
4254781 acaagaacct cccaccgcgc ttgatgatcc cgttcttttc ctgttccacc ccgggcaaaa
4254841 accccggtgt gtccacgacg aacaccagcg ggatgtcgaa cgcgtcgcta aaccggatga
4254901 accgtgcggc cttgtcggac gcctcgttgt cgatcgcccc cgacatgtgc atgggctggt
4254961 tggccaccac accaacggtc cgcccgtcca cccgcgcgta gccggtgatg atcgcctgcc
4255021 cggcctgggc agcgacgtcg aggaagtcgc cgtcgtcgaa gatccgcagc aggacctcgt
4255081 gcatgtcgta ggccatgttg tccgagtccg gcacgatcga gtcgagttcc agatcgtggc
4255141 cggtgatttc gggttccagc ccggggttga cgaccggcgg tttgtcgaag cagttggacg
4255201 gcagaaacga cagaaagtcc cgcacgtact ggtatgcggc ggcctcggac tccaccacct
4255261 gatggatgtt gccgtagctc gcctggtggt cggcgccccc cagctcgtcg aggctgacgt
4255321 cctcaccggt gacgtccttg atgacgtcgg ggccggtgac gaacatgtaa ccctggtcgc
4255381 gcaccgccac caccagatcg gtctggatcg gcgaatacac cgctccccca gcgcatttgc
4255441 ccaaaatgat ggagatctgc ggcaccagcc cactgagcag ttcgtggcgg cgccccagct
4255501 cggcgtacca ggccagcgag gtgacggcgt cttggatgcg ggcgccgccg gagtcgttga
4255561 tgccgacgat cgggcagccg accatcgcgc accactccat cagccgggcc accttgcggc
4255621 caaacatctc cccgacggtg ccgccgaaca cggtttggtc gtgcgagaac acgccgaccg
4255681 gccggccgtt gatgaggcca tgtccggtga ccacgccgtc cccgtagagc gcgttggggt
4255741 caccgggggt gcggcacagc gctccgatct ccatgaagct acccggatcg accagctcgt
4255801 agatgcgggc gcgggcactc gggatgccct tcttgtcgcg cttggcggcg gccttctcac
4255861 cgccgggttc cttggccaac tccaggcgtt cgcgcagctc cgccagcttc tcggcggtgg
4255921 tatgcagaac cggctcggtg acggtcactg cttgcctacc tcacttgttc gatcggcctc
4255981 gatctgcccc aacgcgcggc tcatgtgttc gcccaccttg gcgatgatcg gctcgtcgat
4256041 ggcctgaatg tgctcgccac cgatcggcac cacctcgagg tcggaaacgt actcgcccca
4256101 cccgccgtcc ggctggcgca cggcgtagcg gggctcgaac atgatcgcgt cgtcatggta
4256161 gcgatcggcc atgtagaggg tgacatgccc gtcgtacggc tggatctggg cggtgtcgat
4256221 cgcccggttg tccagatacg acgtgcgttg gtgttcgatg atcccggccg ggatctgcac
4256281 accggactgg ctgacggcgt ccagcacgaa ccggacctgg ccctcgtcgt cgagctcctc
4256341 gagctgctcg tacgggatcg ccgggatggt cacgttgaac gtcttctcgg cgaaggcggc
4256401 gtagcggtcc cagcgcttgc ggatctcctc cttggtctgc gggatctcct caccggcgcg
4256461 caccgcgtcg atcagcccga cgaaccgcac gtccttgccc agccgccgca aaccgatcgc
4256521 gcacgcgtag gccagcacac cgcccagcga ccaacccacc aggacatagg gcccgtcgcc
4256581 ctgcatctcg atcagcttcg gcacgtactg ctgtgcacgc tcttcgatcg acccctcgac
4256641 ccgttcgaag ccatacattg gggtgtccgc cggcagccgg cccagcagcg gctcgtacac
4256701 caccgtcgag ccgccggccg gatgaaacac gaacaccggc accttcccgc ctgcttcggg
4256761 ccgcgcccgc agggtgcgga cgaacccatc gatctgcccg gcctccaaat acgtgcgcac
4256821 cttgtcggcc agcgcctcga tgttcgacga cgtcagcacg tcctcggcgg tgatcgggcc
4256881 ttcggcgcgc tcggaaagcc gctgcgcaat cttggccgcg gcctcgtcgt ccagcctggg
4256941 cagctcgttg aagatgccgc ccggggactt gccggtgacg atcgcccagg tggcgaaggt
4257001 gacccgctcg gcagcgtccc gcggcggcac gtcgacgttg agcgcgggcc ctgtcgggtt
4257061 tggctgctcg ccgttttgcg gcgacgggag cgcaaccccg gcttccgagt cgaccggctc
4257121 ggtcttgccc accttgccat gcagcaattc ggcctgggcc cgcgcgatct cctcagcggt
4257181 ctgggttttc tggtgctcgt gcagctgctg cacctcgtca cggtgctcga ccgcgtattc
4257241 gatcagcttc tccacgttgt agaggttggc gtcgcgcacc gcggtcagct ggatcggtgg
4257301 caggtcgaag tcgtactcga cgcggttttt gatgcgcacc gccatcagcg agtccaggcc
4257361 aagctcgatc agcggcacct cccacggcag gtcctcgggc tcatagccca tcgcagaccc
4257421 gacaatcagg cccagccgct cggcgatggt ctcaccggaa tcaggcgacc atcgggtcat
4257481 gccggacggc atgtaacggg tggtcaggct gtccgaaagc gtctcggcgt ccgcgtcttc
4257541 ggcgggcgtt tccggcgcga caggcgcccc gtccgcaacc gcgatcgccg tcgccgcacc
4257601 caccgcggtg ggcaacaccg attcggaccc cgctcgggac accagggcgt cgtagaccag
4257661 cgtgaaggac tcgtcgatgc gggcgtgcac ctgcaccgag gcgccgccgg ggtgacgggt
4257721 catcgtcgtc accagccggg cgccgtcgcc gggcaccgcg cgctgctcgg cggcggtcag
4257781 ttgcgcgtcc ggaagcacgt gggcggcggc ggccctgacc aacgcggcca agtccacatt
4257841 gccgtcccgc ggcgcgtact cccagacgtg ccgcccatcc ggcagggcga catgggtgcc
4257901 cggcatgtac gtcgagccgt cgccggagaa gtgcgcgggc agccagtgct ccttgcgctt
4257961 gaaccgggtc ggcggaatgt tcgcgtaatc ctgcggccca ctggcgcggc taaacagcgt
4258021 gcgtatgtcc aggtcgtggc cgtacacata cagctgcgcc atggtcgaga ccatcgagga
4258081 gacctcgtct tgcttgcggg ccagcgtcgg gatcaactgg gcgtcatgca gcccggcatc
4258141 ggcggtggtc agggcgacct gcatcagcgc caccggattg ggtgccagct ccaggaaggt
4258201 ggtgtgcccg ctgtcgacgg cgttgcggat gccgtgggtg aagtagacgg aatgccgcag
4258261 ccccttcttc cagtattcga cgtcgtggat gggttcgccg ccgggtttga tgtagcggcc
4258321 ctcgtgcacc gtcgagaaga tcccacacgt cgggctcgtc ggcttgatgc cttgcagctc
4258381 cgcggtgagc tcgcccagca gcgggtccat ctgcgaggtg tggctggcgc ccttggtcgc
4258441 gaatttgcgg gcgaacttgc cctcggcctc ggcgcgggca aggatcgcgt ccacctgctc
4258501 gggggggccg ccgatgaccg tctgggtggg cgcggcgtag acacacacct ccagatcggg
4258561 gaagtcggag aacacttctc tgatttcgtc ggcggagtat tccaccagcg ccatcaaccg
4258621 gatgtactcg ccgaacagca tcgcctcacc ctcgcccatc aggtgcgagc gcgagcagat
4258681 cgcccgggtg gcatcccgca gcgacagccc gccggcgaag taggccgacg cggcctcacc
4258741 cagcgactgg ccgatgaccg cggccggttt ggcgccgtga tggcgcagca gctcacccag
4258801 cgcgatctgg atcgcgaaga tggtgacctg ggtggtctcg atgccgtagt cctgcgcgtc
4258861 gtccaggatc agctccagca ccgagtagcc cagctcgtct tggaccaggg cgtcgacctt
4258921 ctcgatccac gccgcgaaca cctcgttgcg caggtacagg ctcttgccca tcttgcgatg
4258981 ctgggcgccg aatccggcga gcacccagac cgggccggtg gtcaccggcc cgtcgacgct
4259041 gaacacgttc ggcgcctgct tgcccgcggc gaccgcgcgc aggcccttga tggcctcgtc
4259101 gtggtcgtgg gccaacacca ccgcgcggga acggccgtgg ttgcgccgcg acaacgacct
4259161 gccgatcgat tccagcgagg aggcctggcc ttccgggctt tgcatccagt ccgccaactc
4259221 ggcggccgcc gccttcttgc gggacgtcag aaacgccgac accgccaacg ggaccaatgg
4259281 tgccgtaacc tcttgggccg caagctcttc caacgcggct tccttgagcc gcagcgcctc
4259341 ctcggtgact ccgggcagtt cgggctccgg ctcttcggcg accgccgagt cggtgatgat
4259401 gttgccgaac tcgtcgaacc gcagcgcgtg gcctgccaac gtgggcgcct cggcgggttc
4259461 ggcggccgcc ttgggttccg gctcgggttc cggttccttt tccaccacgt cacgcggcag
4259521 gacctcgcgc accaccacgt gcgcgttggc gccgccgaag ccgaagctgg acaccccggc
4259581 cagcgcgtag ccgccgtatc gcggccagtc ggtgggcgtg gtgatcatct tcaaccgcat
4259641 cgcgtcgaag tcgatgtagg ggctggggcc ggcgaagttg atcgacggcg gcagtttgtc
4259701 gtgctgcagc gccagcacca ccttggccat gctggccgcg ccggccgccg attccaggtg
4259761 cccgacgttg gttttcaccg cacccagcag cgccggccga tcggccggac ggcccctacc
4259821 gaccacccgg cccagcgcct cggcctcgat tgggtcgccg aggatggtgc cggtgccgtg
4259881 cgcctcgatg tagtcgacgg tgcgcggatc gatgccggcg tccttgtagg cccggcgcag
4259941 cacgtcggcc tgcgcgtcct ggttgggtgc gatcaggccg ttggaccggc cgtcgtggtt
4260001 gaccgcgctg ccggcgatca cggccaggat cgcgtcgccg tcgcggcggg cgtcgtcgac
4260061 ccgcttgagc accagcatgc cgccgccttc ggagcgggtg tagccgtcgg cgtcggctga
4260121 gaacgacttg atccggccgt cgggcgccag caccgcaccg atctcgtcga aacccagggt
4260181 gaccatcggt gtgatcaacg cgttcacccc gccggcgacc actacgtcgg cctcgccgtt
4260241 gcgcagcgcc tgcaccccct ggtggatggc caccagcgaa ctcgagcacg cggtgtcaat
4260301 ggtgaccgac ggtccgtgga agtcgtagaa gtaggacacc cggttggcga tgatcgagct
4260361 gctggtgccg gtgatcgcat acgggtgcgc gaccgtcggg tccgacaccg ccaggaagct
4260421 gtagtcgttg gtggagctgc cgatgtacac accgacggcc tggccgcgca ggctcgacgc
4260481 cgggatgcgg gcgtgctcga gcgcctccca ggtcagctcc agcgccatcc gctgctgcgg
4260541 gtcgatgttg tcggcttcgg tcttggccac cgcgaagaac tccgaatcga agcccttgat
4260601 gtccttcagg tagccgcccc gggtgcgggc cccggcgacc cgcgcggcca gccgcggctc
4260661 ttcgaggaat tccgaccagc gcccgtcggg caggtcggtg atcccgtcgc ggccttccag
4260721 cagcgcctgc caggtctgct cgggggtgtt catctcgccc gggaagcggg tggacaagcc
4260781 cacgatcgcg atgtcgacgc gctcggccgg gccggtgcgc gaccagtctt cggcgtcatc
4260841 gcccgctagg tcggtctccg gctcgccctc gatgatccgg gtggccagcg attcgatggt
4260901 cggatgcgcg aacgccaccg cgaccgacag cgtgaccccg gtcaggtctt ctatgtcggc
4260961 ggccatcgcg acggcatcgc gcgacgacag acccagctcc accatgggca ccgattcgtc
4261021 gatcgagtcc ggtgcctttc cgacggcctt acccacccag ttgcgcagcc actggcgcat
4261081 ctcggggacc gttagctcgg ccctttcggc gggggcgttc tcctgggatt ccgctacgtc
4261141 agccatgggt cctcagtccg aagtggcgaa gaccgtcggg gaacccacgc cactgcgcag
4261201 gctgccgtcg aggtaggccg cacggcaggc gcggcggccg atcttgccgc tggaggttcg
4261261 cggaatcgtg ccggccgaca ccagcaggac gtcacgcacg gtcaccccat gcccgacggc
4261321 gatggccgcc cggatgtcat cgacgatggg ctggtggtcg agcttatgcg tgccggccgc
4261381 ccgttcgccg acgatcacca gctgctcgga ggtgtcctcg gggtcgaatt tcagcccggc
4261441 gtgcgagtcg tcgaacactg tctgaggaag ctggttggcc ggaaccgaga aggccgccgc
4261501 gtagccaacc cgcaacgcct tggtcgactc ctgcgccgtg cactcgagat cctgtgggta
4261561 gtgattgcgg ccgtcgatga tgacgaggtc cttgatccgg ccggctatgt agaggtggtc
4261621 cttgaagtag gtgccgtagt cgccggtacg cacccacagc gcgtcgtctg gggcgccctc
4261681 ggcgcgcgac tcgctgatcc gcgatttgag gatgttcttg aaggtctggg cggactcttc
4261741 ttctttgccc caataaccgg tacccaagtt gttgccgtgc agccagatct caccgatctg
4261801 tccgtccggc agttcgctgg ccgtgtcggc gtcgacgatg accgcccatt cgctgacccc
4261861 gaccttgccc gcagagacct gggcgacggc gttgggtgca tcggcggcca cctcaacgaa
4261921 ccgctggttg ttcagctcgt cgcggtccac gtggatcacg gtgggcacct cgtccatcgg
4261981 cgtggtcgag acgaacagcg tggcctccgc tagcccatag gacggcttga cggcggtctg
4262041 cttcaaaccg tacggcgcaa atgcttcgaa gaacttgcgc atcgacgccg gcgacaccgg
4262101 ctcgctgccg ttgaggatgc ccttgacgtt gctcaggtcc agcggcggct cgtcgtctcg
4262161 aggcacaccg cgcaccgcgg cgtgttcgaa tgcgaagttc ggcgccgcag agaaggtgcc
4262221 accggtttct ccgggcttgc gggcgagctc gcggatccag cgaccgggcc gccgcacgaa
4262281 cgccgcgggc gtcataaagg tgaagctgtg gcctagcacc gacgccagca gcaccgtgat
4262341 cagacccatg tcgtggaaga acgggagcca gctgaccccg cggtcgcctt cctgtccttc
4262401 cagggcattg agcacctgca ccacattggt gggcaggttc agatgggtga tctgcacgcc
4262461 gctcggtatg cgggtggaac ccgacgtgta ctgcaagtac gcgacggttt cctcgttggc
4262521 ctcgggctgc tgccaggtgg cggcgacttc ggtgggcacc gcgtcgacgg caatgacgcg
4262581 cgggcgctcc ttggccgatc gggcccggat gaacttgcgg accccttcgg cggagtcggt
4262641 ggtggtcagg atcgtcgacg gggcacagtc gtcgagcacc gcgtgtaacc gaccgacgtg
4262701 ccccggctcg gccgggtcga acaacggcac cgcaatgcgg ccggagtaga gggcgccgaa
4262761 gaaggagatg aggtagtcca ggttctgcgg gcacaggatg gcgacgcggt cacccggctg
4262821 ggtgacttgc tgcaggcggg ctcccaccgc acggttgcgc gcgctgaagt cagaccacaa
4262881 gatgtcgcgc gcgacaccgt ctcgttcggt ggaaaagtcc aggaaccggt aggccagctt
4262941 gtcgccacga accttcgccc acttttcgac gtgacgaacc aggttggtgt tggctgggaa
4263001 cctgatcttt ccattcacga tgaacgggtt gtggtacgcc atcccactct ctcctgtcac
4263061 aaacatctcg gccggctctg ccggcggcca ccgggtgtcg gctccgccaa cgggttaccc
4263121 gcgcacatca acccctaccg cgctcacgtc ggcgaacgca gtttgcagcc agctttgacc
4263181 cgactgggtc ctgcacatgc tcttagtttt ctcttaatgt taagggccgg tgcctgacag
4263241 accaaatcac aaggtaccgc tgttcgaggc cgccatcaac gtacgcgggg cggtgtcgag
4263301 tcgcccggtt catcggtgga ccgccgccta gcgtccatcg tcctcgggga aatatcacct
4263361 atgtttgggg tggggcgcat tttcgataag ttgatgcgcc cagttcaacg tccactcggt
4263421 cgccggttct ccatcggaat tccagaattc gggtgtcgca tacatagcat ggaccggctg
4263481 gccggcgccg ccggccaggg tgttcagcgt agtcggcaag ttggcgggac tgaacgcctg
4263541 tgccggggcc gcacagatca ggtcgccctg ggcgcagatc tcgttggtcc ggccgtcgag
4263601 cgcaccaaaa ccgcccggcc gcgggccggt catagtcaaa ccaagcccgg acaacactgg
4263661 gacttcgtgc agggtgatct cggcgccttc gccgcgcggg ctaggcggga cctgattacc
4263721 caccccctgc tgacgacgac cgtcggcgat cagcgtcacg cctagtacta ggtcctcgtc
4263781 cacgggtccc cggccgttgc cgatatcgct agccacgtcg cccgcgatca ccgcgccctg
4263841 cgaaaacccg atcagcacat agctggtcaa cgggcacctg ttgttcatat cggtcatcgc
4263901 tgccaccatc gcgcgggtgc cctctgcccg gctgtcgttg tacgacatct gattatccgt
4263961 ggtcagcgga ttgtggaatt gggccgtgta ggcaactgtg taggtctgca cccgggcggg
4264021 tgcgaattgc tgggcgatcg gcccagttac cttgagcagc aacgccttcg gaaactgcac
4264081 cggattcagt gggttctgct gcggcgatga ctcccaggtt ccgggaaccg agatcatctg
4264141 cacgtcgggg caggacgcat cctggaaggc cggtcggggt ttgtgcggat gtgctggggt
4264201 gggccccggt ggtaaaactc ctggcggcac cgcgctgggc ggcgattcgg cgccgcgcag
4264261 catgatcacc acggccacga tgaccagcgc tacgacggac gccatcgcgc ccgccgctat
4264321 ccaggcaagg attcggtggc gcttacgccg agagttcttg gccatgttct cctgctaaca
4264381 gagtcggtag cgcacgcgaa aggggtgcac ccgcgccgcg cgatagcgcg gccatcccgc
4264441 ccgttgccgc actccctcta cggtaccggc ccgctacgcg gcttcgcccg agtcgcgatg
4264501 tcgtgcacgt ctgccgcaag gatcatccga tagcggccag gcagctcgca tcggcacctg
4264561 gcttagcgga tcgcaccgac gatatcgccc gacatagcgc ccagctgggg cgcccacgag
4264621 ccccagccgt tgtcaccgct ggctgggaag tcgaagtgtc cgttgtgccc gccgacgctg
4264681 cgatactggt tgtagaacat gcggctgtta cccatcgcct cggcggcttg gccgatcatg
4264741 gcggcgggat cgctggctcc cgggttggtc gggctccaca cccacacccg ggtgttgttt
4264801 tgcgccagca ggctggcatg cacccacggg tcgtgccact tccaccgacc cagctgtggt
4264861 gctccccaca ttccgttggt gtccacaccg ccgaattgct gcatgcccgc cgcgatcgca
4264921 ccgttggtgg tggtgttcga cgggtacaaa aagcccgaca tcgagccagc gaagccgaag
4264981 cggtcggggt ggaaggccgc cagcgccatc gccccgtaac cgccctgagc ggcgccaacg
4265041 gccgcatggc caccgggggc caagccccgg ttagcggcca gccagtcggg cagctcagcg
4265101 gacaagaagg tgtcccactg cttgctgcca tcctgctccc agttggtgta catgctgtac
4265161 gcaccaccgg ccggtgccac caccgaaatc cccttgcccg ccaacgtgtt catcgcgtta
4265221 cccgcggtga cccagttact gacatccggg ccggcgttga aggcgtccag cagatacacc
4265281 gcgtgcggcc caccggctag gaaggccacc gggatgtccc ggcccatcga gggcgacggc
4265341 accatcaggt tctcgtatgg ggcggccttg gcggtgggtt ccgcggctac cgcgacaccg
4265401 cccaacccga atgacagtgc ggcaatccag agcgcccgca gcagcgccga ccgacccttc
4265461 atgtgtccac ctccgtcgtg taaggctgtg tgcacccggc gtcagaccgc cccggccaac
4265521 ccctagcccg tcaggtagct aaccacacgg cccgcggcgg gagctaggga cgggatttag
4265581 gaaacatcta gcggcggcga ccacaagggt caccgccgct agatgttgtg tctgttcgga
4265641 gctaggcgcc ctggggcgcg ggcccggtgt tgggcgtggc acccagtgcc cgttgcaggt
4265701 cgggcttcat agcgttgagc tgcgcgcccc agtactccca gctgtgcgta ccgctgtccg
4265761 ggaagtcgaa cacgccgttg tggccgccac cggcgttgta ggcgtcttgg aacttgatgt
4265821 tgctggtccg cacgaagccc tcgaggaact tggccggcag gttgttgcca cccagatccg
4265881 acggcttgcc gttgccgcag tacacccaga cgcgggtgtt gttggcgatc agcttcccga
4265941 cgttcaacag cgggtcgttg cgctgccacg ccgggtcctc cttcgggccc cacatgtcgg
4266001 aggccttgta gccgccagcg tcacccatcg ccaggccgat cagggtggga cccatcgcct
4266061 gggaggggtc caacaggccc gacatcgctc ccgcgtagac gaactgctgg gggtgataga
4266121 tcgccagcgt cagcgccgaa gaagcagcca tcgaaagacc gacgacggcg cttccggtgg
4266181 gcttgacgtg cctgttggcc tgcagccacc ccggcagctc gctggtcagg aaggtctccc
4266241 acttgtaagt ctggcaaccg gccttgccgc aggcgggctg gtaccagtcg gagtagaagc
4266301 ttgactggcc acccaccggc atgaccaccg acaggcccga ctggtcgtac cactcgaacg
4266361 ccggggtgtt gatgtcccag ccgctgaagt cgtcctgcgc gcgcaggccg tcgagcaggt
4266421 acagggcggg cgagttggca ccaccacttt ggaattggac cttgatgtca cggcccatcg
4266481 acggcgacgg cacctgcagg tactccaccg gcaagcccgg ccgggaaaat gcccccgcgg
4266541 tcgccgtgcc accgacggcg ccgaccagac ccgacactag ggccgcgccg acggccccga
4266601 ccacgagtcg acgcgacata cccgtgacgg cgccacgaac cctgtcaaca agctgcattc
4266661 ttgcttccct catcctcatc tcaacgcatc catgcatgtt tgggcgcatc ctgaattagg
4266721 tcagactgca ggcgctgggc ccggcagtgc tcgtgtagtc aaccacaact tcgggcgtcc
4266781 acccgcatca agcgcaccgc cgaaaccctt atccggcggt cgttcacggc caattcggga
4266841 ccgacgcgac ggcctgaagg tggcatttcc gcagtgtctg ggcatgtgtc gaccgctagt
4266901 gccggctcaa ttgtgatctt gctgtcagta ttgcccccgc gctcattgcc cctcactccc
4266961 gcggtggcgg gccgggcccg tcgggaacat cgagcccaca ccggaccaat tcatagcgcg
4267021 gaacgcggtc gatgcggtaa cgggtgaact cgtaggaatg caacacgttg gagaggaatc
4267081 ggtgcagggt gatcggggcg cgcacagaat taagcaccgc ccgagtcgcg gggcattgca
4267141 gggccgcttc ggcttgcgtg acccactgct ggtcgatgta gccgggaata cccgggtacc
4267201 acttcaccca gggtccgtcg gcgatcaccc agtccgggaa cagattcttg tcatggccga
4267261 tacgggcatg cttcagccgc tcggtgtgcg cggccaatgg gtttaccagc ccgatttggt
4267321 cgatcacccg gacatcgagc ccgacgttca tgcctagcat gcccatgttg gtgaaaaaca
4267381 ctgcgtgctg cggtttcggc gccggcttgc cacccggcgc ggtccccgac gagggccgga
4267441 tcatcggcac caggtcccac tggttgtagt tgcccgacgg caatagcaac gccccttccg
4267501 gggtgttgtt gagcgctgta agcacggcag ccattcgcgg gtaatcgagg tagtccgcgg
4267561 cggtcagcgg atgcgcgtgc ccggtggcct gggcgtagaa gcggcgctcg tcgacgatgc
4267621 ccgaataggt gacccgggtg gcgtcgtcac ccatgcccgg cgagtttgcc gcccacagcg
4267681 accaacccgc gatccccagc cagagcccgc tgagcgcgcc gactagccag cgaccggtct
4267741 cccgcgaaaa gtccttaccg tcgggcagca aaataggaat gacccccacc ggggccagca
4267801 aacaaaacag cggcgccagc aacacccggc cgtgcataaa gtcgccgcct tgccgaatcc
4267861 agtacagcgc ctgcagcacg ccgctgccga cgatgaaagc caccacggcc ggcggacttt
4267921 gcaccgcccg ggccacccga ccgtagtcgg gtgccagcac gggacgcagg aacgacggcc
4267981 ggcggcgcgc cgtcatcaac agcaatccca gcggcaccga cagcaccaac ggcacccaca
4268041 gtgcgtacgg ccggttgaag ttcgacacgt agatcatgcc ttgcgaccac ttgtcgcccg
4268101 cggcatcctt ggccagcgcg gtactcggaa ccagcagtcc gtaatagccc atccggaaga
4268161 tctggtaggc caccggcaag aatccgccgg ccagcacgat cagcacgcgg cgacgccagg
4268221 tccgcgcggc gatcaacatc atgatcagcg ccagcccgcc gatcagcgcg aattccggcc
4268281 gcactagcac gctgcatccg gcgacgaagg ccaacgcgcc gaggaacatc tggctgtccg
4268341 ggcgggcccg cagcggctgt gaccagcaga ccatcatcca ccacaacagc cccagatagg
4268401 ccaacaccag cccgctctcc aggccggagg tggcgaagtc gcgggccggt ggcaccgcga
4268461 tatataccag cgccccggcc ggaagcatga tcgcccgacg gccccgcagg ctgggtgcgt
4268521 acaaccggcc ggtccccagc atgagcagca ccattcccag cagcgaaagc accatggcca
4268581 gggccaacgc cacgtactcc aggcgcatcg gcccgcccac ccagccgccc acatacagca
4268641 gatacgtcca cgctgtcgag gtgttcgctt cgactcgctc gccctggttg aagaccggtc
4268701 cgttgccggc caataggttg cgtaccgtcc gcaggacgat cagtccgtcg tcagcgatcc
4268761 agcgacgttg ccagctcccc cagccgaaca gcacggcgac cgccgtcacc gacagccaca
4268821 agctgacccg gaccatgggc tcatacggaa acaccggccg accgacccgc ccgaccaccg
4268881 gccggcgggg cagcaccccg actgggagga cgttgagctt gaggctagcc gaaggcaaca
4268941 gcggccccaa ccgttgctat ccacgccagc gccagcagct gcaatacccg gtcacgcagc
4269001 gcgatatctt ccggctcccc ggccaggccg ccatcgacgt ccaccgcgta gcgcaggatc
4269061 gcgatggtga acggaatcat cgacaccgcg aaccaggacc cgctgtagcc gtcgcgctcg
4269121 aaagcccaca gcccgtagca caagaccacc gcggtggccg acaacgtcca gacgaaccgc
4269181 agataggtgc tggtgtagct ttccagcgac ttgcggatcg cagcgccggt gcgttcggcc
4269241 agatgcagct cggcgtagcg cttgccggcc accatgaaca gcgaaccgaa tgccatgatc
4269301 agcaaaaacc acttggacag cgggattttg gtggccacgc ccccggcgat ggcgcggatc
4269361 aaatacgccg acgacacgac gcagatttcc accaccgctt gatgcttgag accaaagcaa
4269421 tacgccaact gcatggcgag gtagacgacc attaccagcg ccaggttcgg ggtcagcatc
4269481 caggcaccgg ccagcgatgt cactcccagt accaccgcca cggtgtacgc cagccactcg
4269541 ggcaccacgc cggcggcgat cggccggaac cttttggtgg ggtgctcccg gtctgcctcg
4269601 acgtcacgca catcgttgac gaggtacacc gccgaggcgg ccaggctgaa caccacgaag
4269661 gccatcgaca ccttgctgag cacctcgacg tagtcgtagc ggacaccgcc gcccaacgcg
4269721 gccagcggcg cggccagcac cagcacgttt ttcacccact ggcgcgggcg gatcgccttg
4269781 accaccccgg cgaccaggtt tgccggaggt tgagtcacca catcttcact catccgagct
4269841 catctcttcc gggccctttg ccggcccccg ccgacgctgt ccacgatggc cccgacggtg
4269901 gcgcccagag caacacccac ggccacatca ctggggtagt ggacccccag cagtattcgc
4269961 gacagcgcca tcggcggcac cagcacaacc ggtagcggca gcccggtggc tctgcccatg
4270021 agcagggccg cggccgtggt cgaggtggcg tgtgccgacg gaaagctcag ttgacttggc
4270081 gtgtccacgt tgaccgcgat ggccggatga tccggccgct gacgccgcac cagccgcttg
4270141 atcagcacgg cgatggcatg ggcgacgaac gcgcccgccc ccgccacaag ccattcccgg
4270201 cggcgccgtg gcagggctat cgcgcccagc agcgccagga tcagccaacc gatgcagtgc
4270261 tcgccgaagt gggagagtcc gcgcgcagtg gccagcatcc ccggacggtc gaccagcgcc
4270321 gactgcacgg ccaccatcac ggcgacttcg ccgcgtggcg cccgttcagc catgctcggg
4270381 ctcttggttt gccgccggca gcagcgccgt ctcccacttc tgcttgctgg acagcgtcgg
4270441 caacgcgtcg cgataaatcc ggcgcatctc ctcgaaccgt ttcagcaact ggcgctgacg
4270501 gcgcaacgac tgccacagca acgcgaacat cttggcccgg tcgcgctgcc ggtagaccac
4270561 gccgcatccg tcggccgtgg tgacggtggc cccgtcgaca gtgcacagca ggaaccagcg
4270621 cgcatcctgg gtcggaacgt tgaactccgg gcgacggtgg tgttgggggt tggcggcggt
4270681 caggttgtgc atgatcccgc gggccagccg gtagccgatg accaacgggt tcaccggcgg
4270741 cttcattgcc ttgttcttgt gcaacggcgg cggcaactca ctggccgccg gcagcaccac
4270801 cgcgtccgga tagctcttgc ggatgcggtg cacttgcggc agcgccgatt ccaggatcga
4270861 aaagatgtgc tcggggccgg cgagaaagtc gtcgatggcc ttgttctgga ttgccaccgt
4270921 cgaatattcc aggcaggcaa ggtgtttcag ggttgccttg agatggctgc ggaccaggcc
4270981 gatgacttgc gcctttgggc cgtcccagtg catggcggcc accaccagcc ggttgcgcag
4271041 atggaaatag gcctgccagt cgatggcgtc atccttatcg ctccaggcca tgtgccagat
4271101 cgccgcaccg ggcagcgtga cggtcggata cccgtgctcg gcggcccgca ggccgtaatc
4271161 ggcgtcgtcc catttgatga acaacggcag cggctgtcct agctcttcgg cgacctggcg
4271221 tgggatcatg cacgtccacc agccgttgta gtcgacatcg atacgccggt gcagcaactt
4271281 gctacgggag ttgttgtcgt tcaacgggta ttcggcgaag tcgtggtcat actcggcatg
4271341 cggcgcggcg gtccacatga atatcgaccg gtctacgact tcgcccatga tgtgcaggtg
4271401 cgacggctcc tgcaggttga gcatctgacc acccaccagc atcggcgcct tggcgaaccg
4271461 gtgcatggcc agcacccgca gaatcgagtc cggctcgagg cggatgtcgt cgtccatgaa
4271521 taggatctgc tgacagtcgg tgtttttcag tgcctcatac atcacccggc tgtagccgcc
4271581 ggaaccgccc aggttgggct ggtcgtggat ggagagccga ctacccaatc tcgcagccgc
4271641 ggcggggaaa tccgggtggt cgcgcacctt gcgctcaccc tgatcaggca cgatcaccgc
4271701 cccgatcacc tggtccacca gcggatcggc ggtgagttct cgcagcgcgt tgacgcagtc
4271761 tgcggggcgg ttgaacgtcg ggatgccgac cgcgatgttg gccgtccccg gagcggggct
4271821 ggtggcatac cagccaccac tgtgcagggt gaccgcggtg tcggtggtga tgtcgaacca
4271881 gacccacccg ccgtcttcga aaggctgcag caccacttcg gtctccacgg cggctggctg
4271941 atcctcggtg ccggtgaagt cgtggccctc aacgaagatc cgggcaccgg tggccttggt
4272001 ccggtagacg tctacccgcc cggcgccggt cacctgcacg cgcaacacca ccgatttgca
4272061 cgtcgtccaa cgtcgccaat agctagccgg gaaagcgttg aagtaggtgg cgaacgacac
4272121 ctcggactcc gcgccaatct gtagcgaggt ccgggttggc gcatgcgcgc gccgggcgtt
4272181 ggtcgttgac tcctcgaggt acagcttgcg cacgtcaagg ggttcacctg ggcgcggcag
4272241 gatgacccga gacagcaggc tcgcggcgag ttcactcatg cgccgtcctg aagcagtggg
4272301 acgccgtcgc gcagatgcgg cgcgaggacg ttgtcgtaca tgttcaaggc gctggcaatg
4272361 gccatatgca tatccagata ttggtaggtg cccaaccggc cgccgaacag taccttcgat
4272421 gacgcggtct cggacttcgc cctggcccga taggtggcca acagggcgcg gtcagcctcg
4272481 gtgttgatcg gatagtatgg ctcgtcgtcg tcctcggcga accgggagta ttcccgcatg
4272541 atcaccgttt tgtccgttgg gtagtcacgc tcggggtgga agtggcggaa ctcgtggatg
4272601 cgcgtgtagg ggacgtcgag atcgttgtag ttcatcaccg cggtgccctg aaagtccccg
4272661 atcggtagca cttccacctc gaagtccaag gtgcgccagc ccaatcggcc ttcggcgtag
4272721 tcgaagtagc ggtccagcgg gccggtgtaa acgaccgggg ccgccgggct gccggggcgc
4272781 agctggccgc gcacgtcgaa ccagtcggtg ttcagcctga cctcgatgcg gtggtcagcg
4272841 gccatgtttt gcaaccacgc cgtgtacccg tcggtcggca aaccctcgta agtatcgctg
4272901 aaataccggt tgtcgaaggt gtagcgcacg ggaagccgcg tgatgttggc ggccggaagt
4272961 tctttggggt cagtctgcca ttgcttggcc gtgtacccct tgacgaacgc ttcgtagagc
4273021 ggccggccga tcagcgagat ggccttctcc tcgaggttct gcgcgtcggc ggtgtcgatc
4273081 tcggcggcct gctcggcgat cagctggcgg gcttgctcgg gcgtgaagta cttgccgaag
4273141 aactgcgata ccaggccgag ccccatcgga aactgatatg cctgcccgtt gtgcatcgcg
4273201 aagacccggt gccggtagtc ggtgaagtcg gtgaactgcc gcacgtagtc ccacactctc
4273261 ttattagagg tgtgaaacag gtgcgcaccg tacttgtgga cctcgatgcc ggtctgtggc
4273321 tcggcttcgg aataggcatt gcccccgatg tgcgggcgcc gctcgaggac gagcacgcgc
4273381 ttgtcgagtt gggtggccac gcgctcggca atcgtcaggc cgaagaatcc tgagccgacg
4273441 acgaaaaggt caaaacgagc ggtcatcggt tgcatagggt aaccgacctt gctggcaaaa
4273501 cccgatttgg cagctcgtgg cggtcatggc ccgaacgggt ttcaccgcag gtgcgcatgg
4273561 ccgaccagtg tggttggccg gaggtcgttt ggtcgcgatt gcctcacgat tcgatataac
4273621 cactctagtc acatcaacca cactcgtacc atcgagcgtg tgggttcatg ccatgcactc
4273681 gcgaccgcgg gagccggcga acccggcgcc acacataatc cagattgagg agacttccgt
4273741 gccgaaccga cgccgacgca agctctcgac agccatgagc gcggtcgccg ccctggcagt
4273801 tgcaagtcct tgtgcatatt ttcttgtcta cgaatcaacc gaaacgaccg agcggcccga
4273861 gcaccatgaa ttcaagcagg cggcggtgtt gaccgacctg cccggcgagc tgatgtccgc
4273921 gctatcgcag gggttgtccc agttcgggat caacataccg ccggtgccca gcctgaccgg
4273981 gagcggcgat gccagcacgg gtctaaccgg tcctggcctg actagtccgg gattgaccag
4274041 cccgggattg accagcccgg gcctcaccga ccctgccctt accagtccgg gcctgacgcc
4274101 aaccctgccc ggatcactcg ccgcgcccgg caccaccctg gcgccaacgc ccggcgtggg
4274161 ggccaatccg gcgctcacca accccgcgct gaccagcccg accggggcga cgccgggatt
4274221 gaccagcccg acgggtttgg atcccgcgct gggcggcgcc aacgaaatcc cgattacgac
4274281 gccggtcgga ttggatcccg gggctgacgg cacctatccg atcctcggtg atccaacact
4274341 ggggaccata ccgagcagcc ccgccaccac ctccaccggc ggcggcggtc tcgtcaacga
4274401 cgtgatgcag gtggccaacg agttgggcgc cagtcaggct atcgacctgc taaaaggtgt
4274461 gctaatgccg tcgatcatgc aggccgtcca gaatggcggc gcggccgcgc cggcagccag
4274521 cccgccggtc ccgcccatcc ccgcggccgc ggcggtgcca ccgacggacc caatcaccgt
4274581 gccggtcgcc taagccccgg gtcggccgaa aacgcacccg cggccaaggc gtcggtcatt
4274641 gcttcggccc gtcacaatta ctcgcctaag ggtcgctagg tgttctcgag agttttatcg
4274701 caccgattcc gtgtcgtctc attaatacca atagaaacac acgtaacatc agctggtgcc
4274761 gtcccgcacc cgcgcgccga cgacgctgct caccgcgatg gcagcgaccg tcgtcatcgt
4274821 cgcgtggata gcgaatcgtc cacccgccag ctcccatgaa ccatcgccga cgcccaacac
4274881 ccagctcgcc gagcagccac tgatcgggct cggcggcggc gtcacggtac gcgaactcac
4274941 ccaggacaca ccgttttcat tggtggcgtt gactggcgac ctggccggta cctccgctcg
4275001 tgtgcgcgcc aagcgcccgg acggtgactg ggggccgtgg tatcagaccg agtatgaaac
4275061 cgaaccacgc gatccggcgg gcaccgacgg gtccgtggaa cttggaggac tcaatccggg
4275121 tccccgtagc accgatccgg tgttcgtggg caccaccacc accgtgcagg tcgcggtgac
4275181 tcgcccgatc gacgcaccga taactcaacc gccggcgggg cggccgccca acgacttgct
4275241 cgacagcggt ttgggatacc gtccagccac caaggaacag ccattcgggc agaacatctc
4275301 cgcgatcctg atctcgccgc cgcaagcgcc gcccggaacg cagtggacgc caccaaccgc
4275361 agtcaccatg gcaggccagc cgccggccat catcagccgg gcggaatggg gcgcagacga
4275421 gtcactgcga tgcgaaacac cggagtacga caggggggtt cgtgccgcgg tggtccacca
4275481 caccgcgggg agcaacgact actctccgct ggagtccgcc ggcatagtca aagccatcta
4275541 cacttaccac agcaagaccc tgggctggtg tgacatcgcg tacaacgccc tcgtcgacaa
4275601 gtacggccag gtgttcgagg gtagcgccgg cggcctcacc aagccggtcg aagggttcca
4275661 caccggcgga ttcaaccgca acacctgggg ggttgccatg atcggcaact tcgacgatgt
4275721 ggcccccacg ccgatccaga tccgaaccgt cggccggctg ctcggctggc ggctgggcat
4275781 ggacgacgtc gatcccagga gcatggtgga tctgcagtca gcgggtagct cgtacaccac
4275841 gtttccgggt ggcgccatag cgcgattgcc cgccatcttc acccatcgcg acgtcggcaa
4275901 caccgactgt ccgggcaacg ccgcctacgc tgtgatggac gagatccggg acatcgcagc
4275961 acatttcaac gacccgccgg aggagctgat caaggcgctg gaaggcggcg cgatctatca
4276021 gcgctggcag gcgttgggcg gcatgaacag cgcgctgggt gcaccgacct cgccggaggc
4276081 cgacgccgcg gatggggcgc ggtatgcaac cttcgctaag ggcgccatgt attggtcgcc
4276141 ggtgaccgac gctcagccga tcacgggggc aatctatgag gcctgggctt cgcagagcta
4276201 cgaacgcggc ccgctgggac tgccgaccag cgcggagatc caggagccgc tgcagatcac
4276261 gcagaacttt caacacggaa ccttgaactt cgagcgcctc accggcaatg tcaccgaagt
4276321 cgtcgacggg atcacgacgc cactggcgac gcggcccccg agcggcccga cggtgccgcc
4276381 cgaacacttc acgctgccaa cgcatccgat cacctgagtc gcgggtgtgc actattcaca
4276441 ttatgtgtgt gcacttttca cattctggct tttgcggcgc ggaatcgccg gcgcatagac
4276501 accctgtgcc attaggctcc atttgccggg ctgatcaccg ggtcgccgca ggccagtcga
4276561 gaggaacaac gtgtcgttcg tggtcacagt gccggaggcc gtggcggctg cggcggggga
4276621 tttggcggcc atcggctcga cgcttcggga agcgaccgct gcggcggcgg gccccacgac
4276681 cgggctggcg gccgcggccg ccgacgacgt gtcgatcgct gtctcgcagc tgttcggcag
4276741 gtacggccag gaatttcaaa ccgtgagcaa ccaactggcc gcgtttcata ccgagttcgt
4276801 acgcacgttg aaccgcggcg cggcggcgta tctcaacacc gaaagcgcta acggcgggca
4276861 gctgttcggt cagatcgagg cgggacagcg cgccgtttcc gcggccgcgg ccgccgctcc
4276921 gggcggcgca tacggccaac tcgttgccaa cacggccacc aacctggaat ccctctacgg
4276981 cgcatggtcg gccaacccgt tcccattcct ccgccagatc atcgccaacc agcaggttta
4277041 ctggcagcag atcgccgcgg cgctcgccaa cgccgtccag aacttccccg ccctggtggc
4277101 gaatttgcca gcggccatcg acgcggccgt ccagcaattc ctggccttca acgcggcgta
4277161 ctacatccaa cagattatta gctcgcagat cggcttcgcc cagctattcg ccacgacggt
4277221 cggtcagggg gtcaccagcg tcattgccgg gtggcccaac cttgcggcgg agcttcagct
4277281 agcgtttcaa cagcttctgg tgggtgacta caacgccgcg gtggcgaacc tgggtaaggc
4277341 catgacaaac cttctggtca ccgggttcga caccagcgac gtgacgatcg gcacaatggg
4277401 caccaccatt agtgtcaccg cgaaacccaa gctgctgggc ccgctgggag atctgttcac
4277461 catcatgacc atcccggcac aagaggcgca gtacttcacc aacctgatgc ccccctccat
4277521 cctgcgagac atgtcgcaga acttcaccaa cgtgctcacg acgctctcca acccgaacat
4277581 ccaggcggtc gcttcgttcg atatcgcaac caccgccggg actttgagca ccttcttcgg
4277641 ggtgccattg gtgctcactt acgccacatt gggtgcgccg ttcgcgtcac tgaacgcgat
4277701 tgcgacgagc gcggaaacca tcgagcaggc cctgttggcc ggcaactacc taggggcggt
4277761 gggtgcgctt atcgacgccc cggcccacgc gttagacggc ttcctcaaca gcgcaaccgt
4277821 gttggatacg ccgatcctgg tgcccacggg gctcccgtcc cctctgcccc cgacggtcgg
4277881 gatcacgctg cacttgcctt tcgacgggat tctcgtgccg ccgcatcccg tcaccgcgac
4277941 gatcagcttc ccgggtgctc cggttcctat tcccggtttc ccaaccaccg taaccgtttt
4278001 cggcacaccc ttcatgggaa tggctccgct gctgatcaac tacattcccc aacagctcgc
4278061 cctggcaatc aaaccggcgg cttagcgcgg cgtggcccgt tggttggtgt cgtaggttgc
4278121 catgccaagc tccaaccatg cggttagcag ccgctgatct gccgccgcgg ccacaacctc
4278181 gtcgtcatcg agttgctcgg ccgatgcgca gtgcaccgcg tcgtagccac gcatgggcca
4278241 ggtcagccgc gcgggtcacg acctgctcat ccacctcgat ggcgtccatc tcggaccaca
4278301 tctggtcacg gttcgcccgt cgcgaatctg cgcgaggggc cggctcagtc acgcactccc
4278361 gagccacaaa ggcgccgggt cacgtgggcc atgctaggac caccagcgct ccagcacccg
4278421 cgcgacgccg tcctcgctat tgggtgcagt gacctcgtcg gcgacggcca gcgcgtcggg
4278481 atgcgcgtta cccatcgcca cacccaaacc ggcccgcagc agcatcggca cgtcgttggg
4278541 catgtcgccg aacgccacca cctccgcgtc ggaaattcca agcggccggg caatctcgtc
4278601 gacaccggtg gccttgctga taccgagcgg cacgatctcc accagcccgt tattggtcga
4278661 gtaggtgata tcgccctcga aaccgacatg cttagccagt tcggcggcca tgtcggcact
4278721 ggcagcaccg gctttacgga tcagcagttt gatcgccggc gcgctgagca ggtggtcgat
4278781 cgacacttcg gtgttgtccg gattcagcca cgcatgctcg tagcccggcg agctgacgaa
4278841 ctggggggtc gccgtgtcgt gtgcgcgctc gccgatccgc tcgaccgcca gtcccgcacc
4278901 cggtatgacg cgggtcgcaa cttcggccaa cgttgccagg gcgtcgacgg gcagggtgcg
4278961 caccgacatc acccgatcgg tcccggggtc gtagatgacg gcgccgttgg cgcacaccgc
4279021 catcggcgcg aagccgaggg catcgacgat gggtcgcacc cagcgcggcg gccggccggt
4279081 ggccaggatg aagtgcgtgc cggcgtctac cgcggcatgc accgcgtcgc gagtgcgttt
4279141 ggtgacggtt tctccgtcat cgagcagggt tccgtcgacg tcacacgcga cgagcgccgg
4279201 cacagtcggt ttcaaagttg gctggcttgt cagtgcgggc cgacttggct gcgccgtgat
4279261 gaggtcacgc cgtcgtatcc gcgcttttgc cgccgcttcg ccaattcagc gattctgagc
4279321 tgcctggact cctccaccgt cggcgcgccg ccgcccagcc gccgcggcac ccagtgctcc
4279381 cccttgggat gtggatactc ctcctgtacg cggtagagaa tcgcattcat cgcttggcgc
4279441 agcacggcat tgagctgctc ggcattgccc tccggccgca ccggcgatcc gatcgccgcg
4279501 acgatcggaa tcttgttgcg gaacaggttc tttggatgat ccttgggcca gatccggtgc
4279561 gcgccccaga cgatcatggg aataatcggc acctgcgcct ccagcgccat ccgggccgct
4279621 ccggtcttga actcgcgcag ttcgaggctg cggctgatag tcgcctccgg gtgtaaccca
4279681 acgagttccc cggcccgcaa ccgctgcact gccaccgcgt acgcatcggc ccccacactg
4279741 cgatccaccg ggatgagctg ggcatgcttg atcacgtagt tgaccgcccg tacgtcttgc
4279801 atctcggcct tgatcatgaa ccgcagccgc cgccgccgat ggtgggcggc gatcgatgcc
4279861 ggaacccagt ccacgtagct cgtgtgattg agtgcgatca acgcgccgcc acgttcgggg
4279921 atgttctcca ggccttcgaa tgtgatcttg tttccgttgg ccgcgacgat cgacggaaca
4279981 agaatctcca tcatccggaa gaacggctca gccatgtatt ctccttcacc tcttaccgcg
4280041 attcatgcgg tgtccggcta gcggcccttg ccgccgcctc gtcagcctcc atccgtgccg
4280101 cctcggccag cgttggcgcg ccgccgccga gtcggcgggg cacccagtac gccccagccg
4280161 gatgcggata ccgctcctgc gcttgccaca gcagcgcggt catcgactca cgcagcgccg
4280221 cgttggtctg ttcgatgcct gccgcggccc gcagcggccg acccacctgt accgtgaccg
4280281 gcaccttggc gcgtcctatc tgcctgggat ggtccttggt ccagatccgc tgagcacccc
4280341 agacaacgac gggcacaatc gggacatccg cttccgcggc cattcgggcg gcccccgtct
4280401 tgaacccttt gagctcgaag ctacggctga tggtggcctc cgggtagacc ccgaccagtt
4280461 ccccttcgcg cagccgctgc accgccaccg cataggcgct accgccggcg ccccggtcca
4280521 ccggaatggt ccgggtgtgc ctgatcagga agttgaccaa ccgcacccgt tgcatctcgg
4280581 ccttgatcat gaacctcatc cggcgacgcc gacgatgcat ggccaacgcg gccggcagcc
4280641 aatcgacata gctggtgtga ttgatagcga ccacggcgcc gccttggtcg ggcacattct
4280701 cctcgccgac gtaggtgatc cgggttccgg tggccagcac cagcaactgg gccaggatct
4280761 ctaagacgcg ataggtcggc tccgccatcg gtcactgctc cggcgccccg gcgggatggg
4280821 ctcgctgagc gcggcgcgca gccctaaccg ccgcctcctg cgcgtccaac cgggccgcct
4280881 cggcaagcga cggggcgccg ccgcccagcc ggtgcggcac ccagaactcg ccggccggat
4280941 gcggtccgta cagttcttgg gcccgctcca gcaaatgttg catccgggag tgcagcaggc
4281001 cgttcagttc agcggtgggc agcgtcggtt cgatccgttc accgacgaca atcgtgaccg
4281061 gcaccttcgg gcgaaacagc tttttgggac ggtccttagt ccagatccgc tgcgcacccc
4281121 aaacaatatg cggaacgatc ggcaccccgg cctcgatcgc cattcgggcc gcccccgtct
4281181 tgaattcctt gatctcgaag ctgcggctga tggtcgcctc ggggtacacg ccgacgagtt
4281241 cgccggcctt cagcatcctg acggcggcgt cgtaggacgc ggacccgtcc tgccgatcca
4281301 ccgggatgtg gcgcaggctg cgcataatgg gaccggtgat cttgtgatcg aacacctcct
4281361 gcttggccat gaaccgcacc ttgcgcccga ggccctgttg gtaggcgggc aaacccgcaa
4281421 aggtgaagtc gaggtagctg gtgtggttga tcgcgacgac ggcgccgccg ctggtcggta
4281481 ggttatccac acccgtgacg gtgatcttca gaccctgtat gcgccaggac aagcgagcaa
4281541 gccgaatgac ggtgccgtat accggttcca cagcagttca gcctagtggt cccggctgca
4281601 agccgcccaa agtggcgaaa acccaaattg acgaaagagg tgagccgtgt ccttcccctc
4281661 atcgccaccc gcgctgcccg cgatcgttgc ccggtttgcc gtcggcaggc cggtgcgcgc
4281721 ggtgtgggtc aacgaactgg gcggcgtcac cttccgggtg gactccggca tgggcgccgg
4281781 ctgcgagttc atcaaggtcg ccaggagggg taccgccgac ttcgctaatg aggcgcggcg
4281841 gctgcgctgg gccgcgccgt acctggcggt gccgcgggta ctgggtgtcg gggtcgacgg
4281901 cgattgggcc tggttgcaca ccgatgcgct gcccggcttg tccgcggtgc acccgcgctg
4281961 gcgggcgtcc ccgcaggtcg cggtcccggc gctgggtgcg gggctgcgca ccctgcacga
4282021 cagcttgccg gtgcactcat gtccgttcga ctggtcgacg gccagccggc tggccaagct
4282081 ggccccggcg cgacgcgcgg aactgggtga ctcaccgccg gttgatcggt tggtcgtctg
4282141 tcacggcgac gcgtgctcac ccaacaccat cctcgatgac accggccgct gttgcggaca
4282201 cgtcgacttc ggcaatctcg gtgtggccga tcggtgggcc gacctcgcgg tcgcgacgct
4282261 gtcgttgcaa tggaactttc ccgactaccc gggccaggtc agagatgacg agttcttcgc
4282321 cgcctacggt gtggcgccgg acccggctcg catcgactac taccgccggc tgtggcaggc
4282381 cgaagacgac agctcacgct aagctcgagg ctgcgctttg cgctcgtaag ctcttccgaa
4282441 aggtagctgt gcaggtcaca agcgttggtc acgccggctt tctgatccag acccaggccg
4282501 gcagcatcct gtgcgaccct tgggtcaatc cggcctactt tgcgtcttgg tttccgttcc
4282561 ccgacaacag cgggctggac tggggcgctt tgggtgagtg cgattatctg tatgtctcgc
4282621 acctacataa ggaccacttc gacgcggaaa atctacgagc gcacgtcaac aaggacgccg
4282681 tcgtgctgct gcccgacttt ccggtacccg acctgcgaaa tgagttgcag aagttaggat
4282741 ttcatcggtt cttcgaaacc accgactcgg tcaaacaccg cctgagggga cccaacggcg
4282801 atctcgacgt gatgatcatc gcactgcggg cccccgccga cggtccgatc ggcgactcgg
4282861 cgctagtcgt tgccgacggc gaaacaacgg ctttcaacat gaacgacgcc cgcccggtcg
4282921 atttggacgt gctggcatcg gagttcggtc acatcgacgt gcatatgctg cagtactcgg
4282981 gcgcgatctg gtacccgatg gtctacgaca tgccggcgcg cgcgaaggat gcgttcggcg
4283041 cccaaaagcg gcaacggcag atggaccgtg ctcgccagta catcgcgcag gtgggagcga
4283101 cgtgggtggt gccgtcggcg gggccgccat gctttttagc ccccgagctg cgccacctca
4283161 acgacgacgg tagcgatccg gccaatatct tccccgacca gatggtgttc ctggatcaga
4283221 tgcgggcgca cggccaggac ggcgggctgc tgatgatccc cggctcgact gcggatttca
4283281 ctggtacaac cctgaattca ttgcgccatc cactgcccgc cgaacaggtc gaggccatct
4283341 ttaccaccga caaagccgca tacatcgctg actatgccga ccggatggcg ccggtgctcg
4283401 ccgcgcaaaa ggctggctgg gccgccgccg ccggcgagcc actgctgcag ccgctgcgca
4283461 ccctgttcga gccgatcatg ctgcaaagca acgagatctg cgacggcatc ggatacccgg
4283521 tcgagctcgc catcggtccc gaaaccattg ttttggactt tccgaaaaga gctgtacgag
4283581 aaccgattcc cgacgagagg ttccgctacg ggttcgcgat cgcgccggag ctggtgcgca
4283641 cggtgctgcg cgacaacgaa cccgactggg tcaacaccat cttcttatcc acccgatttc
4283701 gggcatggcg ggttggtggc tacaacgaat acctttacac gttcttcaag tgtctgaccg
4283761 acgaacgcat cgcctacgcc gacggctggt tcgccgaggc ccacgatgac tcctcatcga
4283821 tcaccctgaa cggttgggag atccagcgcc gctgccccca tctcaaagcc gacctatcga
4283881 aattcggtgt ggtggaaggc aacacgctca cttgtaacct gcacggctgg cagtggcgtc
4283941 tggacgacgg tcgctgcctc accgcccggg gccatcaact acgcagttca cggccatgat
4284001 gcagttctac gacgacggcg ttgtacagct ggatcgtgct gcactcacgc tgcgccgcta
4284061 tcattttcct tcgggcacgg ccaaggtcat cccactggac cagatccgcg gatatcaggc
4284121 tgaatcgctg ggctttttaa tggcccggtt caatatctgg ggcaggccag accttcgccg
4284181 ctggctgcca ctggacgtgt accggccgct gaagtcgacg ttggtcaccc tcgacgtacc
4284241 ggggatgcgg ccgaaaccag cctgcacgcc cacgcgcccc aaagaattca tcgcactgct
4284301 ggacgagttg ctcgccctcc accgaacgtg aacccacggt ttcgcgcgcg attttcgcac
4284361 tgccctgggg cacagcctca ctccagactt aagccacagc gacgatccaa gcgacgtgtc
4284421 atgtgcctgg tttaagtgtc gcgagcgtgc cgtcggcggt gcggatatag atggatttca
4284481 tggccgcgat gtaattggcg acggattcgc ttgcgatcgg gttgtccggg aataataccg
4284541 tcactgtggt ctgatgctga taccgattga cccacatcga gacctgatga gaaaccctac
4284601 cttcgtcgta aatcctaaaa ttcagatcgg aattagcgac cgtagaaaga ggcgcaatgc
4284661 tggcatccag aaaggacatc acgaaattgc ccggccgggg cggcctcagc cccgtttcgg
4284721 ggcgtgccag ctccaatacg cggtcgaatg gtacggtcgc caggtcctta cccgaatcga
4284781 aggagatctg cgcgacacgg gcggcgctat cgaaaagtcc tgaggcgacc ggcacggtga
4284841 tcggcaccaa cccggtaaac cagcccgtcg ttctgagttc tgtcggcgtc ctacgtgtat
4284901 cagtcgtcgt taccacgtca aacgtttcac agttggtcaa ctcgcgctca gcgagggcgg
4284961 cgcaggcgaa aacgccaccg ctaaaacggg cgcccgcagc gacgcaggcg gcttcgaatc
4285021 gctcgccctg ttgctcgtcc atcagcgttt cggtaagcag ctttccggta tggggcaccg
4285081 atagatcgcc gagcggcaac gggaagtgcg gcagggttcc gtcgttgttg gcagcgaatt
4285141 cgacccaacg gcgcacccgg gcggagtcca acgtcaaggc ggccgtgtcg gcgtactgtc
4285201 ggacacagtg gtcgtcgtag cggcccgccg gcgggagctc gatcggcggg tcgcctccca
4285261 ccaatgcgga gtacatcata tggatctcga tgaaaaggac gcccacaatc atcggatcga
4285321 cacagagatg agcgatactc gcatagaagg tgaagtgatc gtcactctga ataatcccga
4285381 acaagaagca gtcccactgc aacggctgcg gcgttgcaat gtggtggcgc agctccgccg
4285441 acgtcatgtt ctgatgctca gcttggacga cttcgatatc tgcagggtca gcgatggtat
4285501 gccgaacgat gtgttcggca ttgtcgaact caaaccaact gtggtaggtg tcgtggcggc
4285561 gaaggtgtgc gttgatcgca taattcatgg cgcggatgtt gcaccggcca ggtagatccc
4285621 aggtgaagat catcaggcgc gacatatcga gaccgcgcgc tacatgatcg cgataacgtc
4285681 gaaggtgttg agcttgttga tagctgggcg gcacctcact tatcggcgct tgccgggctt
4285741 tcgccttcgc cgtcggtgat gcgtgccaac agataatcga acctgggtcc ggcgtccagt
4285801 cgcggagcgt tgtaatgcta aacactcatt cctcctgcac tcggaccgag ccccgccagg
4285861 gcacgcaagt aagctacggc cagacggtgt gacactcaaa ccggcgggcg taatttcctc
4285921 cgacgacgct ccgcagacca caatcgtcag cggcggagta cggttgctca ccatgtggtc
4285981 caccgtgctg gtcttggcgc tctcggtgat ctgcgagccg gtacggatcg gtttggtggt
4286041 cctcatgctc aacaggcgcc gcccgctgct ccatttgctc acattcttgt gcggtggtta
4286101 cacgatggct ggtggcgtgg ccatggtgac gcttgtggtc ctcggggcca ctccgttggc
4286161 cggacatttc agtgtggccg aggtacagat cgggaccggg ctgattgcct tgcttatcgc
4286221 gtttgcgctg accacaaatg tcataggcaa gcatgtccgg cgagctaccc acgcccgcgt
4286281 cggagacgac ggtggcaggg tcctacggga gtcggtaccg ccaagtggtg cgcataagct
4286341 ggctgtgcgt gcacgttgtt ttctgcaggg cgattcgctg tatgtcgccg gggtgagtgg
4286401 cctaggagcc gcactgcctt cggccaacta catgggcgcg atggccgcca ttcttgcctc
4286461 cggcgctacg ccggcaacac aggcactggc tgtcgttacg ttcaacgtgg tggcattcac
4286521 agtggccgaa gtccccctcg tcagctacct ggcagcaccg cgtaagaccc gcgcgttcat
4286581 ggctgcgctg caatcatggc tgcggtcccg tagccgccgc gacgccgcgt tgctggtggc
4286641 cgccggaggt tgcctgatgc tcacgctagg cctgagcaac ctgtaggcgg cggcgggctt
4286701 gcctaacgca gagctctcac atgaaatgtc caggcgtctc cgactgcgtt gcgaccgtaa
4286761 ggcacgataa cgtgtttgct attgctgctg gtttgcgttg gtcggccgct gtaccgccgc
4286821 tacacaaagg ggacgctgtg accaaactgc tcgtcggggc catcgcgggc ggaatgctag
4286881 cttgcgcagc tatattgggc gacggaatcg cttcggccga tactgcgttg atagtacccg
4286941 gtaccgcacc gtccccgtac gggccactca ggtcgctcta tcatttcaat cccgcgatgc
4287001 agcctcagat cggcgcgaat tactacaacc ccaccgctac ccgccacgtc gtttcatatc
4287061 caggcagctt ttggcctgtc acaggcttga attcgcccac cgtcggcagt tctgtcagtg
4287121 ccgggacgaa caatctcgat gcggcgatcc gcagcactga cggaccaatc ttcgtggccg
4287181 ggttatcaca gggcacgctc gtgcttgacc gcgagcaggc acggttagcg aatgacccga
4287241 cggctcctcc ccctgggcaa ctcacattca tcaaggccgg cgaccctaac aatcttcttt
4287301 ggcgggcgtt taggccggga acccacgtgc cgatcatcga ctacaccgtt ccggccccag
4287361 cggaaagcca gtacgacaca atcaatatcg tgggccagta cgacattttt tctgacccgc
4287421 ctaatcgtcc gggcaaccta ctcgctgacc tcaatgcgat tgccgcgggc ggatactacg
4287481 gccacagcgc caccgcattc tcggacccag ctcgcgttgc gcctagggac attacgacga
4287541 caacgaacag tttgggtgcg acgaccacga cctacttcat ccggaccgat cagctacctc
4287601 tggtgcgggc gctggtggac atggcgggcc tgcccccgca ggcggcggga acagttgatg
4287661 ccgcactgcg gcccataatt gacagggctt atcagcccgg accagcaccc gctgtgaacc
4287721 cgcgtgattt ggtccagggc atccgcggta tccccgccat cgcccctgcc atcgccatcc
4287781 ctatcggcag caccaccggg gccagtgccg ccaccagcac cgctgccgcc acggcagcag
4287841 caacaaatgc gctccgcggg gccaacgtgg gcccgggcgc caacaaggcg ttgtcgatgg
4287901 tccggggttt gctacccaaa gggaagaagc actagccata aagtccacga cctacggtgg
4287961 cgtttcgcag ttgggggtgt aaagggggtt gaggtcttcg acgatggcgg ttgctgctgg
4288021 cccaccaatc cgttgctgct gacgccaatc catcgggaag gccctgggtg gcgtcttggt
4288081 gcgcccggag gggcagcccg ttggcgcccg tcgtcgagcg tgaactgagg gcggacctcg
4288141 ggcagacacg ccgaggtctt ccttttgggc agcgtggaac cgcccatcat cgaaagacct
4288201 cgacccctac cccggcaacg acgcgccgac tacctcacac cctcaactgc gaagagatcc
4288261 taaagcctga gcccgtcgtg taaccaaaga ccgatcagat cgtcgtcgtc gggcggtgat
4288321 tgctcttctt cttccttggg caacaacggc ttacgtttgg ttcgttgggc acggccacgg
4288381 cgtcggccaa ggggccacca ggttgccggc cgccagcttg acggcaacca ccagttcgcc
4288441 tgcccaacca acacggcaat ggcgggcacg gtaacggtac gcaccaagaa ggtatccagc
4288501 aaaagcccgg tccctaggac gaacgcacct tgaaccacgc tacccaagct ggcgaatacc
4288561 agaccgtaca tcgaggcagc catgatcaaa cccgccgcag tgatcacacc acctgttgag
4288621 gccacggtcc ggatgacacc ggaacgcacc cccaagacgg cctcttcacg cagcctagaa
4288681 ataagcagca tattgtaatc tgcgcccacc gcgaccaata taacgaaggt caatcccgga
4288741 atgctccaat gcatttcctg accgagtaaa aattggaaca cgataacgcc aataccgagc
4288801 gccgccaggt acgatacgat aaccgagccg atcagataca gcggtgccac aatcgcacgc
4288861 agcaaaacga tcaatatgag cagaacgatg cagacggtca tggcgatgat caatcggagg
4288921 tcgtgatcgg agtagtcgcg cgtgtccttg agaacgacgg gcaatccgac gacagacacc
4288981 ttggcatcgg ccagtgcggt atttggttgc gcccctcgag cggccgccgt gatcgcgtca
4289041 atttggtcca tggcagcagt gctgaatgga ttcaggtcgg tttgtatcaa ataccgtatt
4289101 gagtggccgt cgggtgaaat gaaggccgcc gcgacttttt tgagttggtc tacattcagc
4289161 ccgcctagca gatcccgata ctctgacggc atcgtctcgg ctttgacgct ctcaccggtg
4289221 gcatacgaca acaactccgg gggaatatag aaccccgcca tcgccggcgt ggtcgcggtg
4289281 tccttcattg ccaataggaa cgccgaggcc tcgcccaacc cgaaacccat cttcttcacc
4289341 tggtcgacca acaactgcac gccctcagcc agttgccggc tcccgtcggc gagatcattg
4289401 acccccttgt tcaccaggtt gatcttggat cgcacaccac caggactgct catccccagt
4289461 gaacccatcg ccctgatgac ggtggccagc gccccgcgta atccggacac ggtggctgcc
4289521 agggtctgca ctgcgcgcgt ggcctgcagc tgtcgagcca actcagatat ctttgccagc
4289581 gttccgtcgt cgcgcgctgt gaccaaacgc tgcagttcgg tgcgcgcact ggcacaagcc
4289641 ggatcggcag tgcacatcgg gctgctatcc agcgccccca gcaccgggct tgcccactcg
4289701 gtgttgttcg ctacaaagct cgcatccgcg tcaatggtgt caccgagtgc ccgcatgctg
4289761 ccgatcagct tctccgcgcc ttccagttcg ccgagaaccc tgttgccccc gagcaggtcc
4289821 tgaaggtacg ccagcgcgtc gatgaggccg ccgaccgtgg atatggcccg gttaacttgg
4289881 gcccgtacgt cgccgagttt gctcgccatc aggttggctc caccggccag tttgtcgatg
4289941 tcgccggtgt gcacagcgat ctgcttggaa ccctcatcca gcttgctgcc gacttcgcca
4290001 gcctgccagg acgtccgggc ctgctccagc gaccgtccag cgggtcgggt aatgcccctg
4290061 accatcgcga cacccggcac ttggctcacc cgctgcacca tctgctctag gtcggcgaga
4290121 gccttcggcg tgcgcagatc cgtcgaggat tggatgaaca ggtactcggg aatgatcagg
4290181 ttagacggga aatgcttgtc caacgcggca tacccgatcg aactctcgac ggaagccgga
4290241 agcgtcttgc gatcgtcgta gttgtaccgg gccagtcctg cgcagccggc cagaataacc
4290301 agcaccagcg cgctggcgag cagatgagtc ttgggccgac gcacgatgtg cacccccgaa
4290361 ctccgccaaa agcgccgggt gaggtcacgg cgcggcgcga tccaaccgcg acgcccggtc
4290421 agcaccatca gggcgggtag cagtgtgaca gctgcgaaga agaccacggc taccgagatt
4290481 cccaacatcg gaccaaccgt tttgagaatt cccagttggg taaacaccat cccgagaaag
4290541 gtgattgcta cggtagccgc ggaggcggcg atcaccttac cgatggatgt caatgccttc
4290601 ttgacggctt gatccgaatc cgcgccctgc cgtaaatagt cgtgatatcg actaatcaga
4290661 aataccgcgt aatccgttcc cgcaccgacc atcatcccgc tcataaaaat aatgctctgg
4290721 ttagcaatac cgaggcccgc caagccggct attgcaacga ggcgctgtgc aaccaccacg
4290781 gacatgccaa ttgttatcaa tggcaacacc atggtgatcg gattcccgta gatgatcagc
4290841 aaaatgacca acaacaggat cgtgatcgca aactcgatgc gactgcggtc ccgttgcccg
4290901 gtgaggttca gatcggcgac ggtggccgcg ggcccggtca ggttagccgt cagtgtcgag
4290961 cctgcgacct ggtgttcgac gatgtcagcg acgcgggcgt acgcctgctt ggactgggtc
4291021 gaacccaggt cgccgggaag gccgaccggc aggatccagg cctgattgtc tttgctggtc
4291081 atgagctccc gcaggggcgg tgtggtgacg aagtcctgga gcatcacgac gtctcgagta
4291141 tcgcgtcgca gggcgtcaac cagctctttg tagctgcgtt catcggccgc gccgagccct
4291201 ttggcatcgc tgagcaccac caccgcaacg ctctgcaacc cggcttcacg aaatgccgcg
4291261 gtcatctgcc gggtcgagac caacaccggg gcgtccgatg gcagaatcgc cactggatgc
4291321 cgctgggaga tcgcgtccag ggacggcacc gtcggcgcaa gcagacccgc aagcgcgacc
4291381 cagaaggcga tcaccaccca cggccttcgg acgataaggc gccctagccg cggaaagaca
4291441 cccccgtcac cggttggcct aagcggtttc gatcgtaagt tcgtcgaggg tctcggtgtt
4291501 ctgacaggct gcatcaagac gtcgcacatt cctcatctgc tccgcacgtg cccgccttga
4291561 gcgccagccg tggtggtcgc tgtgaggcga gtgagacagc aggggatcgg tcacctgacg
4291621 aatttacgtg cgcaaccact aagcttctct atctaccgtc acattcgcaa cctttagatt
4291681 gcagatatcg ataaaatcac ccgcgcgaca agaccgccat gtcatccttt cgatgttatt
4291741 tcgccggcct ggggaaagcg caacgacgtt gcctacacgt tccgccgtcc caccgttggc
4291801 aatgcgcata cacaccgatc taattgccct cagatatgcg gtaacggatt cgcgagcgac
4291861 cggattatct gggaatagca cgctcgccgc ggtctcgtcg aaacgaccga ccatcgtact
4291921 tagcggatag gtgaccctcc cgtcgctgta ggtaccaacg ttgaggccct cgaacagttt
4291981 cgtcaccgcc gagagcggtc ccacttgtgc gtcgaaaaag ttcaccaggg aaaaaagcgg
4292041 ttggggcctg cgcagcgacg gcgacaattc gacgacccgt tcgaacggca ctttcgccag
4292101 atccgcacca gtatcgaagg aggtctgcgc gattcgtgca atctcgttaa aggacaatcc
4292161 ggcgactgga acggtcaccg ggatctgccc ggtgaaccac ccctgcgtca taaggtcggc
4292221 tggtgtgcgg atatctttgg gagtaattcc aaaataggta tcggcgccgg tcaactcgtg
4292281 tatcgcgatg gcgatgcaag ccagcatgcc accaatgaaa cgagcgttcg ccgccatgca
4292341 ggcggattcg aatcgctgtg tttgctgctc gtccattagc atcatgctga gcaggtcgcc
4292401 gccgcagcgt acagacggat ctccgagggg cagcggaaat tccgggaaag ttccgttatt
4292461 gatttcggcg aagtcgatcc acgcgcgcac ctccggggaa tcgacggtca acgccgaggt
4292521 gtactcgtgc tgcctgacgc agaagtccac atagctgcca gcctccgata acccaatcgg
4292581 tggctcaccc attatcagcg cggtgtacat cgactggaac tccatgagtc cgactcctac
4292641 gaactgaccg tccgcatgca gatgatcgat gctggcatag aacgtgaagg agtctgctcg
4292701 ctgaatgact ccgaagctga agcagtccca atgaagcgaa tccggtgtcg ccacgatgtg
4292761 ctgtcgcagg tccgcgctcg tcatctcgcc atgtgtggtc ggaacaaatt cgatatccgc
4292821 cggatcggcg atgctgtgcc gaacgatgtg gtcggtatct cgaagctcga accagctgcg
4292881 gtatgtatcg tgccgacgaa ggtgcgcatt gatgacatag gtcatggcgc gcagatcgca
4292941 gtgaccaaac acctcaacgg acgcaatgag cagccgcgag tgatcgagcc cccgggcagc
4293001 ctgctcagaa aagctccgaa tttgtctggc ttgtacataa ctgggaggca cagcactcac
4293061 cggcgctgca agggctttcg cgcacgaggc aggtgttggg tgccacgaaa ctaacacgcc
4293121 gggcgctggg tcccagtctt tgaccgctga caactctact ggtcctattc gcactaatag
4293181 ctcctatttc agcgcgtgcg gaatacgtat gcggcgaaac gttcttactg tgacgacagc
4293241 gcggcagcag gagcgtcgtc gggcgccagc tgttcataca agtgatccgc taagccccgc
4293301 accgtggcgc tgacgttctt gggtgccaac cggattccgg tctcggtctc gatccgagtg
4293361 cgcagctcta gtgcgcccaa cgaatcaagt ccatactcgg gtagcgggcg gtcagggtcg
4293421 acggtgcgcc gcagaatcag gctgacctgc tcggcgacca gctgccgaag ccgcgccggc
4293481 cactcgtcgc gtggcagctc gttcagctcg acgcggaatt tgcttgtgcc cgaaccgttg
4293541 ctgctggaga acacttcgaa aaaccggctg cgctctgcga aggcgaccag ccacggggct
4293601 ccgatgaccg gggcatagcc ggtatagacg cggttgtggc gcaatagcgc ctcgaacgcg
4293661 taagcacctt cgtcgggagt gatcgccgtg tagttgcttt cctccaatgc cgaagcccgc
4293721 gcgggcgatg ccgaccacca ccccaactgg ccgatatccg accaggctcc ccacgcgatc
4293781 gcggtagccg gcaggccctg agcttgccgc caatgcgcga aggcgtccag ccagctgttg
4293841 gccgctgagt aggcactctg tcccggcgag ccggtgagag ctgccgccga cgaaaacaag
4293901 cagaaccagt caagcggctg tccgctggtt gcttcatgca actcccaggc accgtgaacc
4293961 tttggcgccc agtcgcgcgc cagcaactcg tcggtgatat tggccaaggt ggcgtcctcg
4294021 accaccgcgg ccgcgtgtag cacgcctcgt accggaagcc cggtggccac agcggtcgcc
4294081 accaaccgct ccgcggtacc cggttgggcg atgtcaccgc attccaccac gacttcagag
4294141 cccatcgccg cgatggcctc gatcgtttcc ctcatctttt gcgtcggctg ggtgcgggaa
4294201 ttcagcacga tccggccgca accggccgcg gccatcttct cggccaggaa cagccctagc
4294261 ccaccgaggc cgccggtgat gatgtaggag ccgtcgggac ggaacacctg agcttgttcc
4294321 ggaggcaggg taacgaggct ttttccggtc tgtgggatgt ggaggacgag tttgccggtg
4294381 tgctcggcgt tgcccatcac acggatggcg gtggccgcct cgacgagggg gtaatgggtg
4294441 ctctgcggca tcggcaactc gccggctgcg gtcaagcgat agaccgtgcc gagcaggtcg
4294501 cgcagctctt ctgggtgtgt cgcagacagc aaccccaggt ctacggcgta gaaggacagg
4294561 ttgcgccgga agggaaagag ccccagcttg gtgtcaccat agatgtcgcg cttgccaatc
4294621 tcgacgaacc gtccccggaa ggcgagcagt ttcagcccgg caagttgcgc ggcgccggtc
4294681 accgagttga gcacgacatc gacaccccgg ccgttagtgt cccgccgaat ctgctcggcg
4294741 aactcgatgc tgcgcgagtc atagacatgc tcaataccca tgttgcgcaa tagctctcga
4294801 cgctgtgggg taccggcggt ggcgaagatc tcagcgcccg ccgcgcgggc tatagcgatc
4294861 gccgcttgtc cgaccccgcc ggtgccggag tgaattagca ccgtgtcacc cgccctaatc
4294921 cgggcgagct catgcagtcc gtaccaggcg gtggcgtgcg cggtggtcac cgcagcggcc
4294981 tgtgcgtcac ccaggcccgg tggcagcgtc gcggccagcc gagcgtcaca cgtgacgaat
4295041 gtgccccagc agccgttagg cgacatgcca ccaacatggt caccaacctt gtggtcagtg
4295101 acgcctggtc cgaccgcggt caccacgccg gcgaaatccg tgcccagctg gggcaggtgt
4295161 ccctcgaagc tggggtagcg accgaaagcg atgagtacat cggcaaagtt gacgctggac
4295221 gcacggaccg caacctcgat ctgtcctggt cctggtggaa cgcggtgaaa cgcggccagc
4295281 tctatcgttt gcatatcgcc gggggtacgg atctgcaggc gcatgccgct ctgctgatga
4295341 tccgcgacga tggtgcgccg ctcctgagga cgcaacgggg tcggacacaa gcgcgccacg
4295401 taccactcgt tgtctcgcca ggcggtctcg tcttcttccg acgtggccag caattggcgt
4295461 gccagctgct cgacaccggt ctgttcgtcc acgtcgatct gggtggcacg caggtgaggg
4295521 tgctcggcgc cgatcgtccg cagtagacca cgcagcccgc cctgctcaag attgacgcag
4295581 tcgtcggcca gcacccgctg ggcaccccgc gtcacgacgt acatgcgcgg caccgccccg
4295641 ggaaggtctg acaattcgcg agcgataccc accagccggc gaacgtactc agcgccgcga
4295701 tccgcgctcc cctgatgcgg cgtaccggtg ttcgacccgg tgagcacgac cacgccgcta
4295761 aactcgtcgc taccaacttg atcgcgtagc tggtcggcgg cggccaactg gtcgtcgtgc
4295821 agtggccacc gcatcgtcgt gcacgccgcg ctgtgttccc taaacgcgtc cgctagccgg
4295881 gtagcggtca catcagaggc agcgcagtca ctgatcagca gccattttcc agcgccagag
4295941 gggtccatct cgggcagctc acgctggtgc cattcgatgg tgagtaagcg ctcattcagc
4296001 acccgattgt gtttgtcgcg ctcggacact cccgtaccga ttcgcagtcc gcacacggcc
4296061 agcaacaccg tgccgtgcgc gtccagcacg tcgatatcgg cctcgacgcc gaccaactcg
4296121 actttggtca cccgcgtgta gcaatagcga gcggtacgca ccggagcata ggcacggact
4296181 cggcgcaccc ccaacggcac caataggccg ctacctaccg actggctatc gggatgcgcg
4296241 ccgaccgact ggaaacaggc atccaggagg gccgggtgga ttgcgtacag gccctgctgc
4296301 gaacgaatcg agccgggcag cgcgacttcg gccagcattg tggcggtcgc atcctccgcg
4296361 acataggcca cggccaggcc ggtgaaggcc ggaccatatt gcacaccgtg cttgtcgaat
4296421 tgccggcgca gatcctcacc gtccacgcgg caagggtggg cttccaataa ggaggccatg
4296481 tcgtacgccg gcggctcgca ttcgccggat acctgctgca gcaccgccga cgcacgccgc
4296541 aagtgatgcc caacgccttc ctgcaaggcc tcgacggcga agtcgacgac accgggcgag
4296601 gtcaccgttg ccacggtgga caccggggtc tggtcatcca gcagcagcat cgcctcaaag
4296661 cgcatgtcgc gtacttcgga ctgctcgccg aggacggcac gggccgcaga caacgccatc
4296721 tcgcagtagg cggcccctgg aagagcagcc acgttgtgta tccggtgatc gcccaaccag
4296781 ggcaaggttg cggtaccaac atcggcctgc caggcgtggc gttccggctc ttcgggcaat
4296841 cgcacgtgtg cgcccaacaa cgggtgcacg gctaccgtgg agccacccgg cgaccgattg
4296901 tcaacgcctt cgcggtcata gaacaggaac cggtgcgacc acgccggcag cggagcatcg
4296961 accaagcggc cttggggaca gagcaccgag aagtccactg ccgcaccagc gttgtgcaga
4297021 tccgtcagca ggcgacggag ccccagcggc aatggctgct cccgccgcat accggccagc
4297081 gcggcaaccg gcatgcctac actgccggca atctgatcga ccgcgtgggt cagcagcggg
4297141 tgcggcgaaa gctcggcgaa gactcggtac ccgtcgtcga gcgccgagcg caccgcagcg
4297201 gagaaccgca cggtgtggcg caaattgtcg gcccagtaac gcgcgtcgca cgccggcgct
4297261 tcgcgcgggt cgaaaagcgt cgccgaatag tagggaatct caggagcttt cggattcagg
4297321 tcggccagcg cagctatcaa ctcgtcgagg atcggatcca cctgcggcga atgcgaagcc
4297381 acgtcgacgg ccaccgcccg cgccagcacg tctcgccgct cccatatgtc gaccagcttg
4297441 cgcaccgact cggtgcctcc ggcgatcacg gtggactgcg gcgcggtcac cacggcgacc
4297501 accacatcgt cgatgcctag agcggtcaat tccgactgca cagctaaggc aggcaactcc
4297561 accgacgcca tcgccgcgga accggcgatc gtcgccatca gttttgatcg tcggcagatg
4297621 acgcgtaccc catcttcggc tgacagcact cctgcgacca cagccgcggc cgactcaccc
4297681 attgagtggc cgatcacggc gcccgggcgc actccgtatg ccgccatcgt ggctgccaac
4297741 gcgacctgca tcgcgaagat ggtcggctga actctgtcga tgccagtcac ggtctcgggc
4297801 gccgtcatcg cctcggtgac cgagaacccg gactccgcgg cgatcaatgg ctctagctcc
4297861 gcaacggtcg cggcgaacac cgattcgttc gtcagcagat cggcgcccat cgctgcccac
4297921 tgcgaccctt gcccggagaa taaccagacc ggcccgcggt catcctgccc caccgcgggc
4297981 tggtaaacgg tgtcaccgtc ggcgacctcg cccaagccgg caatcagctc gtcgacgctg
4298041 ctcgcgatga ccgccgtgcg caccgaccgg tgcgtacgcc gccgcgccag cgtgtacgca
4298101 agatccgaga gcaccaggga gtcggcgtgc tgctgtatcc agtcggtcaa ccgctgagca
4298161 gtctgccgca gcgcgtcggc cgaggaagcg gacagcgtga acaaggcagg ggtgccggtc
4298221 gggggggtgc tcgccgcgtg gggctgggct tcggtttgcg gagcttgctc cacaacagcg
4298281 tgcacgttcg ttcccgagaa cccataagac gacactgccg cccgccgggg cacctgacga
4298341 ccgttggtgg gccacggtgt ggtcacctcg ggcacgaaga ggttggtggt gatgccagca
4298401 atctcatcgg gcagccgagt gaagtgcaga ttacgtggaa ccacaccatg tttcagagcg
4298461 agaaccacct tgattagccc tagcaccccg gcggtcgact gggtgtgtcc gaagttggtc
4298521 ttcaccgatg cgagtgcgca cgggccgtcg accccataca cctcggagac acttgcatat
4298581 tcaatggggt caccgatcgg ggtgccgggg ccgtgcgctt cgaccatgcc gaccgtcgcg
4298641 gcgtccacgc caccggcagc caacgccgct cgataagccg caacctgtgc gggctgcgaa
4298701 ggcgtcgcga tattgaccgt gtggccatcc tgatttgcgg acgtgccacg aattaccgcc
4298761 aggatccggt caccgtcggc caatgcatcc ggcaaccgct tgagcaccac cacggcacaa
4298821 ccctcgcctg acacgaaccc gtcagccgcg acatcgaacg cgcgacaacg tccggtcggg
4298881 gacaacatgc ccaaagcgga tccagcagcg gccttgcgtg gctccagcat caaggcgaca
4298941 ccccccgcca aggcaacgtc gctttcaccc tcgtgcaggc tgcgacacgc catgtgcacg
4299001 gccgtcaggc cggacgagca tgcggtatca acggttattg ccggaccgtg cagtcgcatc
4299061 gcgtaggcga cccggcccga cgccatgctg aagctgttgc ccagatatcc gtacggctcc
4299121 tccaattgtt tggcgtcggc cgccaccatc gtgtagtcac catgggtgac acccgcgaac
4299181 acgccggtcg ccgagcctgc cagcgtttgc tgagtaagac cggcgtgctc catggcctcc
4299241 caggacgtct ccagcaacag acgttgctgc ggatcgatcg caatcgcctc ccgctcgccg
4299301 atgccaaaga actcgcaatc gaaatccgcg gggttatcca ggaaaccgcc ccacttgcac
4299361 accgtccgac cgggcacgcc cggctgcggg tcgtagaact cgtcgcaatc ccaccggtcc
4299421 ggcggcacct cggtgatcag gtcgtcgcct cgtaacaacg ccttccacaa caactcgggg
4299481 gaatcgatcc cgccgggcag ccggcaagcc atgccgataa cagcaaccgg agtcacacgt
4299541 ggttcagcca acgtccatgc acccctatct gcaccagtgc ctgacgccgc cgaccccaag
4299601 cccaatgccg gaggcgatac gtagcctaac tagcaatcct tcgatgtagc tgtgtctttg
4299661 gtggctcttt agttctaagc ggctgtgcta ctggggcact gggccctact tcggtttgtc
4299721 gtggcatggg cagcccgcgg tctgccgcag tctgaagttc gcggcctgag cgcgcgctat
4299781 cttccacgcc gggccggtag tctgacgctt catggtttcg ctttccatcc cctcgatgtt
4299841 gcgccagtgc gtcaacctgc acccggacgg cacggcattc acttacatcg attacgaacg
4299901 ggattcggag ggcataagtg aaagcctgac gtggtcgcag gtgtatcggc gaaccctaaa
4299961 cgttgcagca gaagtccgcc gccatgccgc aattggtgac cgtgcagtga tattggcccc
4300021 acaaggactc gattatattg ttgcttttct gggcgcttta caggccggtc ttattgcggt
4300081 tccactttcg gctccgctcg gcggcgccag cgatgaacgt gttgacgcgg tagtgcgtga
4300141 cgcgaaaccc aatgtcgttc tgacaacatc cgcgataatg ggcgatgtcg tcccgcgcgt
4300201 tacgccaccg cccggtattg ccagcccgcc aacggttgcg gtcgatcaac tagatctgga
4300261 ctcgccgata cgatctaata ttgtggacga ttctctccaa acaaccgcat atttgcagta
4300321 tacgtcggga tcgacccgca cacctgccgg tgtaatgatt acctacaaga atatattggc
4300381 aaatttccag cagatgattt ccgcctattt cgccgacacc ggagccgtac cgccattgga
4300441 ccttttcatt atgtcgtggc taccgttcta tcatgacatg ggtttggttc tgggagtttg
4300501 tgcgccgatt atcgtaggat gcggcgctgt gctcacaagc ccggtggcgt ttctgcagcg
4300561 accagcccgg tggctgcaat tgatggcacg cgagggccag gcgttttcgg cggcaccgaa
4300621 cttcgccttc gaactgacgg cagcaaaagc aatagatgac gacttggccg ggctcgacct
4300681 tggacggatc aaaaccatcc tctgcggcag tgaaagggtg catccggcga ccctcaagcg
4300741 ctttgtcgac cggtttagcc gtttcaatct tcgagaattc gcaattcggc ccgcgtacgg
4300801 actcgcggaa gccacggtgt atgtggcgac cagccaagcc ggccaacccc cagaaatccg
4300861 ttacttcgaa ccccacgaac tttccgctgg gcaggccaag ccgtgcgcaa ccggggcggg
4300921 cacagctctg gtcagttacc cgctgccgca atcacccatt gttcggatcg tcgatcccaa
4300981 caccaatacc gagtgcccac ccggaacaat cggtgagatc tgggtacacg gcgacaatgt
4301041 cgccggcggc tattgggaaa agcctgacga gactgaacgc accttcggag gagcactggt
4301101 cgctccctcg gccggcacac ccgtagggcc ttggctacga actggcgact cgggcttcgt
4301161 gtctgaggac aagtttttca tcatcggcag aataaaggat ctgttgattg tttacggccg
4301221 caatcattct cccgacgaca tcgaggcaac gatccaggag atcactcggg gccgctgtgc
4301281 ggcgatagcg gttccgagca atggcgtgga gaagctcgtt gccatcgtcg aactcaacaa
4301341 ccgcggcaac ttggacacag agaggctgag cttcgtcacg cgtgaagtca cctcggcgat
4301401 atccacctcg catggattga gcgtgtcgga tctggttctg gtggcgcccg gctcgattcc
4301461 gatcaccacg agcggcaagg tcagacgtgc cgagtgtgtg aagctgtatc gacacaacga
4301521 gttcacccgg ttggacgcta agccgttgca agcgagcgat ctttagtggt cacgcgactt
4301581 gcaccccgtc tcggggttgt tcggcagcca tgcggctgcc tcccttccgc gcttcacagc
4301641 caccagccgg gcaaggcccg gtcttacggt cggctccacg cttaacgacg ggaaccagcg
4301701 gtcggcgacc accagcgccg acccgtacca gcccgtcttg taggacaagt gccggcgcgg
4301761 agtgcccagg gccgagtccg acagtccgcg ccggcgggcg cgggcgccgg gaagcccctt
4301821 ttgccgcagc atccccgcag cgtccaaacc ttcaacaacg atgtggccgt gggtttgagc
4301881 caatcgtgtt gtcaggacat gcaggtgatg agtgcggaca tcgttgaccc ggcgatgcag
4301941 ccgggaaatc tcggtggtgc gctcgcggta gcgccgtgag cctttcgtgc accgcgaccg
4302001 cgcacggctg gcgtaccgta gctctttgag tgccgtgtcg agtggccgtg gattgggcac
4302061 ttcttcgagc actgcgcccg cctcgttggc gaccgtggcc agccggcgca ccccgacgtc
4302121 aacgccaacc cgtgaaccgg gctgtgccac gttgggctgc tgcgggcgtt gcacgaggac
4302181 ccgcacactg gcgtcgagcc gggtgccgtt acggcgcacc gagattgcca gcacccgcgc
4302241 ccggcctgtg gcgatgagcc gttcaatccg gcgtgtgttc tcgtgcgtac ggacggtccc
4302301 gacgaccgga agtgtgagat gacggcgatc aggttcgacg cgcatcgctc cggtcgtgaa
4302361 tgtcacgcgg tcctgatcgc ggcctttctt cttgaaccgg gggaagccca ttgtcttgcc
4302421 ctcacgttta ccggatcggg agttctgcca gttccagtac gcatcgacag cgccgccaat
4302481 gccgtcggcg taagcctctt tcgagcactc cggccaccac accgccccgg tctcggcgtt
4302541 gacacacacc tcgtccttga cggtgttcca ccgtttacga agcacccgca gcgacggctt
4302601 gacagtcccg ataccagtaa cgcgccacgc ctcgatatcg gctttcaaag tagcgaccgc
4302661 ccagttgtag gccttgcggc gagcgccgaa atgccgcgcc agcgcgcggg cctggtcctc
4302721 ggttgggtcc agcgtgaacc ggaacgcctg cacacaccag ccttctggca cctcgaatct
4302781 ggccatcaag ctgcctccgc gtccccgacc gcagcagcaa gggcacgctt ggccccgttc
4302841 tgtgcagcgc gttcaccata gagccgagca cacatcgagg tcaggatctc ggtcatatcg
4302901 cccaccaggt cgtcatcaac ctcagccaag tcgaccacca ccaattcccg gccctgggcg
4302961 acaagagcgg cctcgacgta ctcagagcca aaccagcaga accgatcccg gtgctccacc
4303021 acgatccgcg tcaccaccgg atcacccagc agcgcaaaaa acttacggcg atgtccattc
4303081 aacgcccaac caccctcggc caccaccttg tcgacagaga gatgttgcga tgtggcccac
4303141 gcggtcaccc gcgcgacccg ccgatccaga tcggacctct gatccgctga cgatacccgc
4303201 gcgtacacca acgtccgccc gcgcccagac tcctcgactg ccggatcgtt caccagaatg
4303261 agccgaccca ctcgctgcgc cggaaccggc aacagcccgg ctcgaaacca gcgatacgcg
4303321 atcacccacg caacaccgtt gcgctccgcc cacaccgcca aattcatcca tctgttccta
4303381 cagcacacca ccgacaacta ccgaccactc aaaacgcaac agttggcagc cctacgatcg
4303441 gccagcgcct gacgggcggc gttatatcca gggatgaacg tgattcccgg cccaccgtga
4303501 caaccggcac tgcccaggta caacccggct atcgggatcg gctggccgat aaagcctttc
4303561 gggccaggcc tgttggggcc gatctggtcc gagtgcagca gggcatggca gtagtcccca
4303621 cccggggcac cgaacatcac acccatgtgt ttgggggtaa aggtggtgta ccggagaatg
4303681 ctgcctttga agttcggtgc caacctagtg atcttgtcga tcacgttctg ccccatttcg
4303741 acctttgccc ggccgtaccc tccgtatttt gagccaccct cgatcgggaa ccacattgcg
4303801 aacgccgacg cggcctgctt acccgccggg gccaggctgg gatcatgcag cgacgggatc
4303861 tgcaacacca cggtcggatc ggccgggacg atcccacgcc ggcaatcctc ccactgctgc
4303921 tgaacctgct ccggtgtaca gaaaatgccc atcgatgcct gcatgctcgg atcgttgagt
4303981 gcctggtagg gcgccgcgaa ggccggtggc tgcgcgagcg caaaatgcat ctgcagatag
4304041 ctgccgcggt ggtcgatgcg caaatagcga tcgcggattt ccgacggcaa cactgccgga
4304101 tcgatcagct cgttgatggt gacgtcgggt gctatggcgg agaccacgat cggggaggtc
4304161 aaggtgtccc ccgccgcggt gcgcacgccc cgcacgcggg ctgacgaccg actattgtca
4304221 accacgatct cggtcacctt ggaacgtaac cggacctcgc cgccggtgcg ttccagcaat
4304281 tgcgacagat gggtggtaag cgcgccgatg ccaccgcgca atttcttcca ccgcacgaag
4304341 tcgccctccg ggacacccaa tccgaaggcg agcgcggcag cgctgcccgg tgtggccggc
4304401 ccgcgataga gcgtgttcac ggccagcacg gtcatcgacc cgcgcagggc gccgtgcttc
4304461 tcgcggtccg ggaaatggcg gtccaacacg tcggtgaccg atccgaacag catgtcatcg
4304521 atcgctgacc gttcgaattc atttgtggca caggcataca tctcgtcgaa gctcttgggc
4304581 agagttccgg cttcgaaacg ccccagcgcc cgggtcggcg cctggctcca cgccagcagg
4304641 cccgccatcc cggtgacggc gtctgccccg tgcacccgat ggaggtgggt aagcatcttc
4304701 gtcgggtcgg tgaattggac caccggatcg tccccgacac cgcgcaacgc taccgacatc
4304761 acctccagat cgaccgtcgg caagctgtcc aggcctaact cgctgctgac cgccgaggag
4304821 gtcgggaact gcaccgatcc ggcgatctcg aaccggtacc cgtcgaacag ctccaccgtg
4304881 gaggccatcc cgccggcgta gcgcttagcg tccagacacg cggtccgcag tccggctcgc
4304941 tgcagcagca ctgccgcggt cagcccgttg tgcccggcgc cgataactat cgcgtcataa
4305001 ccagtcatac gcgtctccag caatgcaggc tcgcacgcgc tcgatgtttt gtcaattatg
4305061 acgaaactgt gagggtggtc caggtgtcgg agatgccgac gcgcagcgac tccagtgcga
4305121 cgtggcagac ccgcgccagc tccccgagcg accggtcact cccaagcatc caggcttcca
4305181 tcgcgccgaa caccgccgcg gcgacgcatc gtgcggtgac ggcgatgtgc aatcgggcat
4305241 cgggtgcacc cgcgatatcg cagttacgtc gccgcaattg ggcctggatg gcatcggcga
4305301 agtcggcttc cacctcgcgc atatggcgga cgatccggct cggctccaac tcgccgcgcc
4305361 gcaacgacgc aatcttcgtc actgcgtcaa cgtcataagg aaacgagaag atagccgctt
4305421 gcacggaatc gatgatcgat tcgtcggccg gtctagcatc cagcgccgcg cgaaaccagt
4305481 gcagtccggc gtcgtagtcg gcaaacagca aatcgtgctt ggatctgaag tggcgataga
4305541 aagtacgcag cgacaccccg gcgtcctccg caatctgctc ggctgaggta gcctcgacgc
4305601 cctgggccag aaatcgcacc agggcggcct ggcgcagtgc ctcgcgagtg cgttcgctgc
4305661 gcgccgtctg cgggggccgg accatgactg caagctatcg tcaattttcg ttctgtcaac
4305721 attgacaaaa ctgttggcca cggcgagact gcgcgcatgg tgtcgcttct tgttcacgct
4305781 gcgctgggag tagtcgtcat cggctggatc gtctcgtcga acccgaaggt tttcaccagg
4305841 ccggccggcg gatcgtggtt ctcgctgccg gagtgtgtgt actacgtcgt cggtattgcc
4305901 tcgatcgcgc tggggtggta cttcaacatt cgttttgtgc agcagtacgc gcacggagcc
4305961 gccaaccctc tctggggtcc cggcagctgg gcggagtacg tccggctgat gttcaccaac
4306021 ccggcggcca gttcggccgg ccaggactac accattgcca acgtgatcct gctgccgctg
4306081 ttttccacca ccgacggcta ccgacgtggt ctgcggcggc cctggctgta tttcgtgagc
4306141 agcctgttca ccagctttgc attcgcgttc gcgttctact tcgccaccat cgaacgtcag
4306201 caccgacacg aacgttcccg tgcgacggtc ggcgcctagg cggcgactgg cttggtggcc
4306261 cgccacctca ggcgagcgcc cgcgacatcg acgtggatat cagtgaatcc cacagctcgc
4306321 agccgaccgg ggaggtccgc cggggcgatc ggagtgtagg tgtcggcgat gtgtattagg
4306381 cgaaacggca gcgacggcac accgtcgctg ccggcaaaga cgccacctgg ttgcagcacc
4306441 cggtacgcct cagcgaatag ctggtcctgc agttgggcgc tggcaacatg gtgcagcatc
4306501 gtgaaacaca ccacggacgt gaagtgatca tcgggcagcc cggtctgggt gccatcgccg
4306561 cggatgatgc gcgcccgctg gccgtagcgg cggttcaggc gctcgaccat cgagttgtcg
4306621 acttcaacgg cggtgagcga ggcggtcagg ccaaggagcg cttgcagtgt cgccccataa
4306681 ccggggccga tctccagcgt ccgggggccg agttcgacgt gctgcaacgc ccagggcagg
4306741 agctgattgg ccaccgcttt ttcccagcct gccgagctgc aatgacgccg atgtagaaga
4306801 ttcatggcca tggcccagaa cactagttag ccaccggccg gcagtcttcc gatattctgc
4306861 cttaatatgt cggaaaacag ccaccacagg ctggccacaa cctcgttgac gctcccgccg
4306921 ggagcgcgga tcgaacgcca ccgccatccg tcacaccaga tcgtctatcc gtccgcaggg
4306981 gcggtctcgg tcaccactca cgcgggaacc tggattacgc cggtaaatcg ggcaatctgg
4307041 ataccggcgg gctgttggca ccaacacaag ttccacggcc acacgcaatt tcacggcgta
4307101 gcgctggatc cgcagcgcta tcgcggcggc ccggcaaccc cgacggtgct cgcggtcaat
4307161 ccgttgatgc gcgaactcgt catcgcgtgt tcgcaggccg accgaaccga caccgacgag
4307221 caccaccgga tgttggccgt actgcaggat caactgccaa caacgagcat ccgcgagcca
4307281 ctgtgggttc cctcaccaac cgatcgccgg ttgcggcacg cgtgcgcgtt gatcgccgac
4307341 aacctgaccc agcccttgac gctgcagcag atcggcggcc ggatcggtgt cagccagcgc
4307401 acgctgagcc gtctgttcag cgacgagctg ggtatgacgt tcccgcaatg gcgcacccag
4307461 ctgcgcctgc aacatgcgct cgtgttgctc gccgagcgcc acgacgtcac gtccgtggcg
4307521 tccgaatgcg gttgggccac accaagcgcg ttcattgaca cctaccgaca agccttcgga
4307581 cacactcccg gccaagccgc taagccaatg gcggcgaccc gcctcacccg gctccgccgc
4307641 gctcgcgatc gccgctaagc gaccggctcc agcacttcga cacccacgaa cggaaccagt
4307701 gcgtccggga ctctaacgct gccgtcgggc cgctggtggt tctccaggat cgcaaccagc
4307761 caccgggtgg tggccagcgt tccgttgagg gtggccgcga tctgcggctt gccgctggca
4307821 tcccggtagc gggtcgccaa ccggcgcgcc tgaaaggtgg tgcagttcga cgtcgacgtc
4307881 agctcgcgat aggccccctg cgtcggaatc cacgcctcgc agtcgaactt gcgggcggcc
4307941 gacgagccga gatcacccgc ggccacgtcg atgacccgat acggcacctc gatgcgtgcc
4308001 agcatctggc gctgccagcc cagcagccgc tcatgttcgt gctccgcgtc ggccggtgtg
4308061 cagtagacga agccctcgac tttgtcgaac tggtgcaccc ggatgatgcc gcgcgtgtcc
4308121 ttgccatggc tgccggcctc acgtcggaaa cacgacgacc agcccgcata ccgcagcggc
4308181 ccgcgggaaa ggtccagaat ctcgccggag tgataccccg ccagcggtac ctcggaggtg
4308241 cccacaaggt agaggccgtc gccctctacc cggtacacct cctcggcgtg ggcgcctaga
4308301 aatcccgtgc ctaccatcac ttccgggcgc accagcaccg gcgggatcgt agggacaaag
4308361 ccgttgtcga cggctagctt cagcgccagc tgcagcaatc caagctgcag tagggcaccc
4308421 cgaccggtca ggaagtagaa ccgtgaaccc gacaccttgg cgccgcgctg catgtcgatc
4308481 aggcccagcg actcgccgag ctccaggtgg tccttggggt tctcgaggta gctgggctcg
4308541 ccgacgacgt cgagcaccgc gtagtcgtcc tccccgccgg cgggtacccc gtccacgatg
4308601 acattcgaga tcgccaggtg cgccgcggtg aacgccgcct ccgcttcgac ctcgtcggcc
4308661 tcagcggctt tgacctgctc ggcgagttcc ttcgcgcgcc gcagcagcgg cgggcgctct
4308721 tcgggagacg cgccacccac gcttttgctg gcggctttct gctcggcccg taacgaatcg
4308781 gcggtcgaga tcacggcccg gcgggcggcg tcggccgtca gcagggcatc taccagcgcc
4308841 gggtcctcgc cgcggctgag ttgtgagcgg cgtaccgcgt cggggttttc acgaagcagc
4308901 ttcaggtcga tcacggccgc aagactactt ttgacgccca gtcagggtgg cggcagagga
4308961 ccatccaccc gcgatgaagc gatcccgcaa gctgacaact gcaacattgg tcatgcggcc
4309021 ccgccgaccc tgtcagaatg gagcggatgt tggacgcgcc cgagcaggac cccgtcgatc
4309081 ccggcgaccc ggccagcccc ccgcacgggg aggcggaaca gccgctgccc gggcctcggt
4309141 ggccacgcgc cctgcgcgcg tcggcgaccc ggcgagcgct actcctcacc gctttgggtg
4309201 gcctgctgat tgccgggctg gtcaccgcga ttcccgccgt cggccgcgcg ccggagcggc
4309261 tggccggcta catcgccagc aatccggtgc ccagcactgg cgccaagatc aacgcttcgt
4309321 tcaaccgcgt cgccagtggt gactgcttga tgtggccgga cggcacgccg gagtctgccg
4309381 ccatcgtcag ctgtgccgac gagcaccggt tcgaagtcgc cgagtccatt gacatgcgga
4309441 cattccccgg catggagtac gggcaaaacg ctgctccccc gtcgcccgcc cgcattcagc
4309501 agatcagcga ggagcagtgc gaagctgctg tgcgccgcta cctcggcacg aagttcgatc
4309561 ccaacagcaa gttcaccatc agcatgctgt ggcccggcga ccgggcgtgg cggcaggccg
4309621 gtgagcgccg catgctctgt ggcttgcagt cgcccggtcc gaacaaccag cagctcgcct
4309681 tcaagggcaa ggtcgccgac atcgaccagt ccaaggtctg gccggccggt acctgcctgg
4309741 gcatcgatgc caccaccaac cagccgatcg acgtgccggt ggactgcgcg gcaccgcacg
4309801 cgatggaggt atccggcacg gtcaacctgg ccgagaggtt tcccgacgcg ctgccgagcg
4309861 aacccgagca ggacgggttc atcaaggacg cgtgcacccg gatgacggac gcctacctcg
4309921 cacccctcaa gttgcgtacc accaccctga cgctgatcta ccccacgctg acgctgccca
4309981 gctggtcggc gggtagccgc gtggtcgcat gcagtatcgg cgcgaccctg ggcaacgggg
4310041 ggtgggcaac cctggtgaac agcgctaagg gggcgctgct gatcaacggc cagccgccgg
4310101 tacccccacc cgacattccc gaggagcggc tcaacctgcc gccgattccg cttcagctgc
4310161 caacgcctcg gcccgccccc ccggctcagc agctgccaag taccccacca ggcactcagc
4310221 acctccctgc ccaacagcca gtggttacgc ccacccggcc acccgaatcg catgcgccag
4310281 cgtcggcagc accggccgag acccagccac cgccaccaga cgccggagcg ccgccggcga
4310341 cccaatcacc agaggccaca ccgcctggcc ccgccgagcc cgcaccggca ggctagccgg
4310401 gtgacagtac ggatggaccc gcagcggttc gacgaactgg tgtccgacgc actcgacctc
4310461 attccgcccg aactggcgga cgccatggac aacgtcgtcg tgttagtcgc caatcgccac
4310521 ccccagcacg aaaatctgct cggccagtac gaaggggtcg cgttaaccga gcgcggctcc
4310581 gactacgccg gatcgctgcc tgatgccatc acgatctacc gcgaggcgct gctggacgcc
4310641 tgcgactctg aggatgaggt cgtcgaccag gtcgccatca cggtgatcca tgaggtcgcc
4310701 catcacttcg gcatcgacga cgagcgcttg gaccaactgg gctggcgtga cgaaccagcg
4310761 cccgggcgcg gcaacccgga tttgtcggca cccgatgcta tgaacggccc atgagcacgg
4310821 actgccgcga ctgccgggcg ggcttggatc actgccacgg caccgtcatt cgtcatccct
4310881 tggcacggcc ggaatgcacc gagccggact gtgtcagccc cgagctgcaa ccccatatct
4310941 tcgtcctaga ctgcaatgcc gtcagctgcg aatgcactga atcggccacg gcgcccgggt
4311001 ccttcagatc agcccatcgg gtcggtgctt gacgtcaccg cgtgtgtgac cgggctggct
4311061 gcggcttcag cggggtccgg acaaaacggc ggcttccgga ggccccactg cacacaactc
4311121 catcgcccat cggttatcgg ggccagcacc accgactcga cgttttccaa gtggttgtcc
4311181 aacacaaagt tgccgtccac cccggcaagc accgcggcgg ccagccggat cgccgcgctg
4311241 tggctcacga cgacgatgtc gccgtcccag tcaccgtcgt cgaggtaacg catgcgcagg
4311301 tcggcgagca ccggcagata acgatccagg acgtcgttgg cggtctcgcc accgggcagc
4311361 ggcacatcca actccccgcg atgccagcgg ctgtaggtgg cgttgaactc ggcgaccgcc
4311421 tcgtcgtcgt tgcggttttc cagctcccct acctgtacct cgtgaatgcc ggcaacctcg
4311481 tgggccacca tgtcgagttc ggcagcgacc accgcggccg tctggtaggc ccggatagcc
4311541 accgagtgtg cgagcagtgc cggccggcga caaccgctgc gcgcgaacgc cctggcctga
4311601 tcacgaccca gcggtgtcag cgccgttccc ggcggcaggg tatccaacct gcgctcgacg
4311661 ttgccatagg actggccgtg ccgcagcagc accaaacgac cgctcatgct tgcgccccct
4311721 ggtcgtccgg gcgaaccagg gtctgctcgg gtttgcccgc gcggagccgc gctaaccagc
4311781 gtgatgcttc gtctaccagg ggcggctgcg cccctgccgc tggccccgtc ggccaggacc
4311841 ccaggtatcg cacatcagca caacgtcggt gcaccgcctt gagtgcctcg gcgacggcct
4311901 cgtcgtcgat gtggccgacg caatccacga agaacagata ggtgccaagt tcggtacggg
4311961 tgggccggga ttcaatccga gtgagatcga tgccgcggat gccgaactcg gccagcgcag
4312021 ctaccagcgc accgggctgg ttgtcgatgc gcagcactgc agacgtgcga tcggctccgg
4312081 tgcgcgccgg aggcggcccg ggccgaccaa ccaggacgaa gcgggtgcgg gcattggatt
4312141 cgtcaacgac accgtcggcc agggccgcca atccccaacg agcggccgcc agcggcgagg
4312201 tcaccgcggc gtcaaccaag ccgtcagcca cctgccgggc cgcgtccgcg ttggaataag
4312261 ccggccgcag gtcggcggcg ggaagatggg ccgccaacca ctgccgcacc tgtgcagccg
4312321 ccaccggaaa ggccgccagg gtccgcacgt ccgcggcgtt gcgcccgggt ttgaccacga
4312381 tgctgaacgt cacgtccagc gttgtctcgg cgaacacctg caggcgcaca ccgatggcca
4312441 ggctatccaa agtaggcagc acggaaccgt cgatcgagtt ctcgatcggc acgcacgcat
4312501 aatccgcacc gccgtcgcgg accgcagcca gtgctgcggg cgcgctctcg accggcatcc
4312561 gctgcagtgc atcgggcccg gtctcgggaa ctaggccggc ggccaccatc cggaccaggg
4312621 ctgcctcggt gaatgtccct tccggaccga ggtaagcgat acgcaccacg ctcacaaccc
4312681 taacgacgca aagccgaccg ccaactcttg cgaccagacc gtgcattagt taacttaggc
4312741 ttacctaaac acaggaggtc gtggatgccg ccgctcacca gtctcgcgcc gactactgcc
4312801 gagcgaattc gcagcgcctg cgcgcgggcc gggggcgcct tgctggtggt tgagcgggag
4312861 gatccggtcc ccgtgcccat acaccatttg ttgtacgacg ggtccttcgc cgtggcggtt
4312921 ccggtcgatc gtggcgaggt gtccggttcg caagcgctgc tggagttgac tgactatgcg
4312981 ccgctgccgg tgcgtgaacc cgtccgttcg ctggtgtgga tccgcggctg cctccaccag
4313041 atcccgcccg cagagctggt tgagaccctg gacctgatcg ccaccgataa tccgaatccg
4313101 gccctgctac aagtcgagac cccgaggccc gggccggccg atgcggcgga gacccggtat
4313161 accatgcagc ggctggagat cgaatccgta gtggtgaccg acgccaccgg cgccgaaccc
4313221 gttaccgtgg cggacctgct cgcggcccga cccgatccgt tttgtgaaat cgaatcaacc
4313281 ttgctctggc acctagccac cgcccatgac gatgtggtcg cgcggctggt atccaggctg
4313341 ccggcaccgc tacgacgcgg acagatccgc cccctcggtc tcgatcggta cggcgtccgg
4313401 tttcgcattg aagctcgcga cggagaccgc gacatccgac tgccgttcca taagccggtg
4313461 gacgacatga ccgggctaag ccaggccatc cgggtgctca tgggttgccc gttccgcaac
4313521 gggctgcgcg cccgcaggta gcaggcacag ccgccgctcg gccgcgttgg ccggctgcat
4313581 ccaaaggttc agccacgtac gttgtctagg tccggggttg gcatccgaca acccgacgac
4313641 actgatatcg atcccgcgtg actcttatgt accgatccct ggccacggcc gggacaaaat
4313701 caacgccgcg ttcgcgctgg gcggggggcg gctgctgacc caaacggtcg agttggctac
4313761 tggcctgcac ctggatcact atgccgaggt cggattcagc gagttcgccg acctcgtcga
4313821 cgccttcgat ccgttggccg gcgtcgatct accggcaggc tgccaaacac ttgacggacg
4313881 tgcagcgctg ggctacgtcc ggactcgggc cacaccacgg gccgatctag agggctccga
4313941 cgtgccggtg ccagccgccg cgttcgaaac acagccctaa cgacacgctg ccgaatatga
4314001 cccgtgtcgg aaattagggc gacaagagta atgcggctca acatagcctt gctttactta
4314061 ggcaaacctg ccttcaacca ggaggttatt atcatcctgt ggtaactagg aaagcctttc
4314121 ctgagtaagt attgccttcg ttgcataccg ccctttacct gcgttaatct gcattttatg
4314181 acagaatacg aagggcctaa gacaaaattc cacgcgttaa tgcaggaaca gattcataac
4314241 gaattcacag cggcacaaca atatgtcgcg atcgcggttt atttcgacag cgaagacctg
4314301 ccgcagttgg cgaagcattt ttacagccaa gcggtcgagg aacgaaacca tgcaatgatg
4314361 ctcgtgcaac acctgctcga ccgcgacctt cgtgtcgaaa ttcccggcgt agacacggtg
4314421 cgaaaccagt tcgacagacc ccgcgaggca ctggcgctgg cgctcgatca ggaacgcaca
4314481 gtcaccgacc aggtcggtcg gctgacagcg gtggcccgcg acgagggcga tttcctcggc
4314541 gagcagttca tgcagtggtt cttgcaggaa cagatcgaag aggtggcctt gatggcaacc
4314601 ctggtgcggg ttgccgatcg ggccggggcc aacctgttcg agctagagaa cttcgtcgca
4314661 cgtgaagtgg atgtggcgcc ggccgcatca ggcgccccgc acgctgccgg gggccgcctc
4314721 tagatccctg gcggggatca gcgagtggtc ccgttcgccc gcccgtcttc cagccaggcc
4314781 ttggtgcggc cggggtggtg agtaccaatc caggccaccc cgacctcccg gcaaaagtcg
4314841 atgtcctcgt actcatcgac gttccagcag tacaccgccc ggccctgagc tgccgagcgg
4314901 tcaacgagtt gcggatattc ctttaacgca ggcagtgagg gtcccacggc ggttgccccg
4314961 accgccgtgg ccgcactgct ggtcaggtat cggggggtct tgccgagcaa caccgtcggc
4315021 agcagcggtg cagcccgccg gatccgccag accgcggcgg ccgaaaacga catcaccacc
4315081 gcacgggatc gatctgcgga ggcgggtgcg gcaataccga accggtgtag cagcgccagc
4315141 agcttgtttt ccaccagcga gccgtatcgg acgggatgct tggtctcgac gaagatcttc
4315201 accggccggt gccagtccaa aaccagcgaa acaagcgcgt ccagggtcag cagactggtg
4315261 tcgccgtgcg aaccgtcggg gcgccagctg tcgtgccacg cgccgtactc cagctcgcgt
4315321 agctgggcca gcgtcatcgt gctgaccaag ccggctcccg tcgaggttcg gtccaggcgg
4315381 cggtcatgca cacagaccag atgcccgtcc cgggtcaacc gcacatcaca ttccacgccg
4315441 tcggcgccct ctttgagcgc caggtcgtag gcggcaaggg tatgctccgg ccgagccgcc
4315501 gacgcaccac ggtgagcaac cacaaaggga tgtccggcga gcacctcgtc ggcccatgtc
4315561 atgtccacta tgctgccggt tcctgcccgt ccaactcaac cgcaacagaa gatgccggcg
4315621 cggaacgccc gtctgtgttc accaccaccc agcgatgcgc tgggcgttcg accggctttt
4315681 gctcgaaccc ctcgaagacc cgcgcagcag cggccaccgc ggccgccgca cacagatacg
4315741 ccagcaccat catggtggtg ttgttggcga tgccctgagc gtcggtgacc cagctggtgg
4315801 cgaacgcgaa catcgatatc gcgttgctga cgatccacac gatccaccac accacgatcg
4315861 gcctgcgcag ccgcgtgtag cggtcctcga ccagcgccaa ctcgatgacg tacagcggag
4315921 cccacagcag attgaccatc ggcaataggc agccggccca taactcacgg gcggaacgcc
4315981 gctccggcaa gccttgatgc ataaacgcgg cggcccgacg ggcgaccagc caccggacca
4316041 acaggacaat ggtagtgccg gccgccgcaa tcgccgccaa gctgaccaaa acccccagcc
4316101 agaccgaggc gctggccacc accgagttca acaatgtgtt tcggttgatg accagcaaca
4316161 cataccgcac cacaaacacc acgaccgcga tgctgaacac cagcaggctc accaacagcg
4316221 tggtgcgcac cgccgccggc gatggccctg ctttcgccga ggccggcacg ggagcctggt
4316281 cgacatggtc ggttagcccc caccgcggta tcccggcgta gcggggagta ggcccacgta
4316341 accgtgggcc gtgccgtggc ggcggtgccg ccccgggtcg caccgctatc caccgaaaac
4316401 ctgggggaag ccgcggcggt gtgcgccgcg tgtcggaggc cgtcggcacc tgcgggcgcg
4316461 ccggtgtacg ccagcgcgcc tcggccggca tatccgccaa cggcgccagc aacatccccc
4316521 gacagcgtgg acaccacacg cgttgccgct cacggacgtt ccagccagtt ccgcactggg
4316581 agcacacttg gatcaccaga ccagcctagt gacttctccg ccccgcaccg gtacggcatt
4316641 gtccgcgccg tcaacaggcg ttgaggcagg cttccgcgct ggattgggcg cgcccggtcg
4316701 cggcacgtcc agcacgacac agctacctac gactatccac agtttccaca gctttatcca
4316761 cagcggtaag aatccgacga atggcgttaa caccggctcc atccgtcagc caggcccaca
4316821 actgtggata acagcgcccg tcaatgcgtt ctcatcgaca gcctggcagg tacccgagcg
4316881 aaatggattg tcgcactaag catccacatc tgccccggct gcacctagca gcctgcccgc
4316941 ccgggcccgg cctgctcctg cgatcgtcaa accacacatt tcgcggcgct gccggcgcag
4317001 tatccggacg tcttgtggcg ctgcgaggta ccaatttttc cccaccattc accaggagtt
4317061 attatcgcgt gcacgacact tcgttgtgac ttacctcacc gtcgtgaggt gagcatgcag
4317121 gtgaaaggcg actgatggcc acacactcgt acggcccagg gtctacaacg ccgccgaact
4317181 ctggctcgcc ggagtggaac cacgcctacg gcattgccgc tttgcgggcc gccctgatcg
4317241 ctctggcgtt actggcgatt ctggccgtca tcgctttggt ttgagtcccc ggccactcgg
4317301 gtggcaccga gtcggtccgg acgccctggt cagaaccggt tctcggattt gggtaacccc
4317361 ccttgtgtca ctgccgtttc ggtggtcaca gcacggcaat tgttgtgggt ggcctttcat
4317421 agaactgcga catggattac cgcggtcgtg aggaaatcgt cgaggctggt tgcaccccca
4317481 cggagccagc cagaaattct gtagatcaga gttggcttga ttatgaatca tgctctagca
4317541 cagggcaact cgtgagtgtg ttgaacacta ccgtcctgtt ctgcgttccg gcactcgaat
4317601 aacctcccgt cccactcgaa atattgcgca gcctaagata aatcagcttc atagccgaat
4317661 ccttgcctgg caaaaggacc gcggttattg attaacttgc gcagctcgat cggatagtcc
4317721 aggaatggca cgaattccgg ctacgcatgc gcccagacaa aattccttga gcgcgagctc
4317781 ggcggcctcc acggtgacgg cgccatgaat cccggcatcg acgagacgcc ccgggctgtc
4317841 ttggatcggc cggcccgagg cgtctttgcg cccgtcaagg tccaccctga tagccaaatg
4317901 cgccagctgg cggcaaccac cccgttgtct tcgatccgca gccgtaaacc gtcgttcgtc
4317961 ggcgcccgtc gcccaacgtg aactgagggc ggagaatcgg ccggaatctc gccctcagtt
4318021 cacgctcggc gccgtttggc ctcacccagt caatgtgatc tgtgcgggcg ggcgttggcg
4318081 cgtagcgaac cccagtggcg ccggcccgcc aagcacgccc cggcgcggcc agctcatcag
4318141 cggctacgca agcgcaacgg cgcccgcgat gggctgtgga agaacccgga ggatctcacc
4318201 gaacaccaga atgccaagct gtcgcgctca tctactcaaa gaaggcctac ggcacctgtt
4318261 ttcggtcaaa ggcgaagaga gtaagcaggc actggaccgg ttgatcttct aggcgcggcc
4318321 ccgagtgagc atactttggt ggcttgtatc tcttgtagtg ccgctttgac ggggtggtgg
4318381 tcaggtacgg tggcctcggg agaggctgga gggctcgacg ttttcggctg agtgtctggg
4318441 cccgtgaaag agatcgtctg ctccagcttt gtctcctgaa ctgacccggt ttagggaatt
4318501 ggtggccagg ttgcggaagt gcgcagcatc gacgtgtacc tgggtgaggc atcgaatcat
4318561 cgacaagcac cggagccgcg cgtgaactcc cgccgcgttg tggtcgggga tgatgtggga
4318621 gaccggccgg cagtgctgtg tacgaaggtt ctcccaccgc aacgagttca cgcacgacgg
4318681 tcggctgggt gggccctgga atacgtgaac tcttcatcaa cacaacatga ttgacgatga
4318741 aggggagaac ctccatgcac aacaacgcta acccgtgact gccgagaatc caggacggag
4318801 caggcggacg ctggtcggaa tcgacgcggc gatcacggcc tgtcaccaca tcgcgatccg
4318861 cgatgatgtc ggtgcgaggt cgattcgatt cagtgtcgaa cccacgctgg ccggactgcg
4318921 caccctcacc gacaagctca gcggttacga cgatatcgac gccaccgtgg aaccgacctc
4318981 gatgacgtgg ctgccgctca cgatcgctgt cgagaatgcc ggtgacacca tgcacatggc
4319041 cggcgcgcgg cattgcgccc ggctgcgggg tgcgatcgtg ggcaagagca agtccgacgt
4319101 catcgacgcc gaggttctca cccgcgccag cgaggtgttc gacctgacgc cgctgacact
4319161 gccgacgccc gcgcagttgg cgttacgtcg atcggtgatc cgacgtgccg gcgcagtgat
4319221 tgacgcgaac cggtcctggc gtcggttgat gtcgttggcg cggtaggcgt tccccgatgt
4319281 gtggaccgcg ttcgccgggt cgttaccgac cgcgacagcg gtgctggggc gttggcccga
4319341 catccgcttg ctggccggcg caccgacccg caactggcgg cgttctacca ccggctgatg
4319401 accacccaga ggcattgcca cacccaggcc accatcgccg tagcccgcaa gctggccgaa
4319461 cgcacccggg tgacgatcac caccggccgc ccctaccagc tgcgcgacac caacggcgac
4319521 cctgtcaccg cccgcggcgc gaaagaactg atcgacgccc actaccacgt cgacaccagg
4319581 acccacccac acaaccgcgc ccacactgac accatgcaga actcgaaacc ggcacgctga
4319641 acaccactgt cggcagggga tccggttgca cacgcaacgg tcacttgagg cgatcgtctc
4319701 cattcctggc tccttgccgc ccattgttgt cggcgagcaa ggagtcacag tggagtcccc
4319761 gcagcgtagc gaggaaaacc gaccttgacg cccgacgagc ggcaacgaga accggcaacg
4319821 aggaatggtc ttcgacaagc ccaccgtgag ttgtctatcg gtttctcatt ttcagcgtct
4319881 tttcagagtc gcgcaacaca atccgatgcc cgtcgagatc cgtcgcgact acacacacac
4319941 ccagcatctc gaccatcgcg actccggccg acgacggcta acgagcagct tcgccccacc
4320001 cgcccccgca gcaacaacac aacggcacgg cagcagctga tcactgccca aaacacgcac
4320061 ccacatcaga tgcagaaccc cttgacaacc aatagggaat ctcttcacga atgagggggc
4320121 agttggggtt tgaatccgcc ggtttccagt aggtatctgt cggcttagtt ggtgagattg
4320181 cgaaagccga gggtcgatcc ccggaggtgc tcgacgcggc cgctgatcgc ttcggtcggc
4320241 gggttgaccg tggtcactgt tttgggcgtc gatccactgc gggaattccc actaccacgt
4320301 ccggccggat caccggcgac tcgcggtgca cggcccgctc cagcacctcc ttggtcaatt
4320361 cgttagccgt ccccgccaac tgcccagccg tcgacttctt cttgcccacc caccccatag
4320421 accttcgcca cacagcgcct tccgtccacc caacagcggt ccgatgacgg acccccgacg
4320481 gggacttcag cgaccaggaa cgcgcccata gacgtggtat cagcctgggg gcgtcctggt
4320541 agcctatgcc gtccgccctg gggcatcgac cccaaggtcg ttgttgcgac gcgagcggtc
4320601 atggagcagg gttgacttgt caagctagag ccagcccatc gcgtgggagg cacccgcgcg
4320661 aaaagaaaca tcggacgatc atttcatcga aggaaggaat gccgtggccg aatacacctt
4320721 gccagacctg gactgggact acggagcact ggaaccgcac atctcgggtc agatcaacga
4320781 gcttcaccac agcaagcacc acgccaccta cgtaaagggc gccaatgacg ccgtcgccaa
4320841 actcgaagag gcgcgcgcca aggaagatca ctcagcgatc ttgctgaacg aaaagaatct
4320901 agctttcaac ctcgccggcc acgtcaatca caccatctgg tggaagaacc tgtcgcctaa
4320961 cggtggtgac aagcccaccg gcgaactcgc cgcagccatc gccgacgcgt tcggttcgtt
4321021 cgacaagttc cgtgcgcagt tccacgcggc cgctaccacc gtgcaggggt cgggctgggc
4321081 ggcactgggc tgggacacac tcggcaacaa gctgctgata ttccaggttt acgaccacca
4321141 gacgaacttc ccgctaggca ttgttccgct gctgctgctc gacatgtggg aacacgcctt
4321201 ctacctgcag tacaagaacg tcaaagtcga ctttgccaag gcgttttgga acgtcgtgaa
4321261 ctgggccgat gtgcagtcac ggtatgcggc cgcgacctcg cagaccaagg ggttgatatt
4321321 cggctgaccc cgctgccgca agcgtcgggc tcagtattcc ggagtcgcgc atcaccatcg
4321381 cccttatcct ggccttatat tgcagctttg tgaacacggc cgcggtggcc gtgtcgagtt
4321441 gcagggcgcg taaaccacgc gcatgcttgg ttactcgagc taccatttat ttcgagctac
4321501 cagcgtggtt aggacggagg cgtcgcggag gggcgagatg ggtaccgggt caggtgggcc
4321561 tattggggtt tctcccttcc attcgcgtgg tgccctgaaa gggttcgtga tctctggacg
4321621 ttggcctgat tcgaccaaag agtgggccca gctgctgatg gtcgcagttc gggtcgcgtc
4321681 gttgcccggc ttgctctcca ccacaacggt gtttggtgcc cgcgaagagt tgcccgacga
4321741 acccgagccg gggaccgtcg gtctggtgct ggccgagggc accgtcttcg gtgaatcagc
4321801 aattcagcca ggatatttcg ctgatcatca accccctgca ttgctgatgc tgcatccacc
4321861 ctcggagacc acgccgtcgc tgccggaatg caccggggcg gcgtcagggt gcgtgctgct
4321921 gccgggatta ccgtatctgg gattggaaca tcgtgcggct tgggtggagg ctgaagccga
4321981 cggcaccatc acatctatgg tgagccgggt gggcgtcgac ccgataagcc atcccgacac
4322041 cgcaattctg gcaatgctgc ttgcagcata aggaaattcg aaggagtctg ttcgggcggc
4322101 gaatcgccaa atacgggtgg ccgaacttgt ccgacatcct ggtgcacacc aaatatgacc
4322161 gctagcctgg ggacgttagc gaaggggagt agtcccgaat cgtcgagtcg acatactggc
4322221 gaaaagcccg gctggcgaac cgtttgatac caacggtggg cgagaccttc gaccgatgtt
4322281 cgatgaccga ctggtcgtcg acaacgcgtc gaaaggtcgc ctgccatgct cgccgccaca
4322341 ctgctaagtc tgggagccgt tttccttgct gagctcggcg acagatccca gctcatcacg
4322401 atgacctaca cacttcgcta ccgctggtgg gtggtgctga ccggggtggc gatcgcagcg
4322461 ttcacggtgc acggggtagc ggtggcgatc ggccactttt tgggctcgac cgtgccggcc
4322521 cggccggccg cctgcgtatc ggcgatcgca ttcctgatct ttgccgtgtg ggtctggcgg
4322581 gaggacacgg ccagcgacag cgaaacctcg ccaaccgctg ccgaaccccg actcgcgctg
4322641 ttcaccgtgg tctcgtcgtt cgcactggct gagctgggtg acaagacaac gttggcgacg
4322701 gtgaccttgg ccagcgatca ccactgggcc ggcgtatgga tcggcaccac cctgggcatg
4322761 atcctggccg acggcctggc gatcggcgca gggctgctgc tgcaccggcg ccttccggag
4322821 cggttgctgc aggtcctgac tggcctgctg ttcctgctgt tcggactgtg gttgctgttc
4322881 gacgacgcgt tgggcttcag atcggttgcc atcgccgtga cagcggcggt ggtgctggcc
4322941 gcggcaacta cggcggtatc ggtgcgggtg gcgcaaactc gtcggcggcg gccaaccgct
4323001 gctgcgacac cagaagatga ctcgacacgc cccgagcggt cgtcggtcgc gccgggccat
4323061 cccgggagca tcttgctacc gcttccggaa gtgtctttgc gggggcgccg accgccctca
4323121 gggtcgcctg acgagcgctg tgcggaccca ggcagcaaag gaggctctcg gcgaatctcc
4323181 gttggctgct ggttgcccgg agtcggccgc atccgcccga cacggtcatc ctgatctgct
4323241 cgccgaacac gtgggcgacg gaccaacgcg cgtgttttca tcggatattc tgcggataac
4323301 ctgtgaaatc cgttcgtcgt gtggacacat caccgaatcg gttggaccct catcgggggg
4323361 gtcttcgttg acccctcaca acgtcagcac ccaatccgct caggtttgca cttggttgtg
4323421 gacacaactg tcgctaccat gatcagcaaa tacatacaga taaccgtttg ctcttggagc
4323481 ccggtggagg tcacatcgat gagcacgacg ttcgctgccc gcctgaaccg cctgttcgac
4323541 acggtttatc cgcccggacg cgggccacat acctccgcgg aggtgatcgc ggcgctcaag
4323601 gcagagggca tcacgatgtc ggctccctac ctatcacagc tacgctcagg aaaccgtacg
4323661 aacccatcgg gggcgaccat ggccgccctg gccaacttct tccgcatcaa ggcggcctac
4323721 ttcaccgacg acgagtacta cgaaaagctc gacaaggaat tgcagtggct gtgcacgatg
4323781 cgcgacgacg gcgtgcgccg gatcgcgcag cgggcccacg ggttgccctc cgcggcgcag
4323841 cagaaggtgt tggaccggat cgacgagctg cggcgtgccg aagggatcga cgcttagtcc
4323901 ctgataccga ccgcccgctc cacccgacct ggcgggttgg ggttggtctg ccccgattag
4323961 ggttgcccca gcgatcaccg cgatagtcca cgagataccg ggaggcggcc gggaatgggc
4324021 ctgttcggca agcgaaagag ccgcgcgacc cgtcgcgcgg aagcccgcgc gatcaaagcc
4324081 cgcgccaagc tcgaggccaa gctgtcggcc aagaacgagg cgcgccgcat caaggccgcc
4324141 cagcgcgcgg aatcaaaggc gctcaaggcg cagctgaagg cccggcggga cagcgaccgg
4324201 gcggcgctca aggtcgccga agccgagctc aaggtagcac gcgaaggcaa gttgctgtca
4324261 ccgacgcgga ttcgccggtt gctgacggtt tctcggctcc tggccccgat actgacgccg
4324321 gtgatatacc gggccgcgat ggctgcccgc gggttgatcg accagcggcg cgccgatcag
4324381 ctcggggtcc cgctggcaca gatcggccgg ttctccggtc atggcgcccg gttgtcggcg
4324441 cgggttgggg gagccgagcg atcgttgcgg atggtgcagg aaaagaagcc gaaggacgta
4324501 gaaaccaaac agttcgtgtc ggcggtgacc aatcggctca ccgatctgtc ggcggccgtc
4324561 gcggccgcgg agcacatgcc cgcaaagcgg cgccggacgg cccactcggc gatctcgtcg
4324621 cagctggatg gcatcgaggc ggacctgatg gcccggctcg ggttgaccta accggcggcc
4324681 cgatgaccgc aattggcatg tcacatccgc ctcgcgtgca tcggcgggtc ggcgggcagc
4324741 gcactgcact gaccgcgggc atcggcctct tgctggccgc cttggtgctg accaccatcg
4324801 cgaacccacc tgcggcgttt gcgcacaccg cgcagctgtc caccgctacg cccgcacccg
4324861 cagtcgccgc caccgacgcg aacgacgtcc cgacgtggcc attcgtcgta gggaccgtgg
4324921 cggcggttgc cgtggctgca ttgtgggccg ttcggcgcgg gcgctaacca atcaaccccg
4324981 gtagcccgga aggtgcggca ccgtgtcctg gcatgatggg accgagcgtt tgcgatctag
4325041 tgagcgacga caatgctgca aaggagcggc cacatgccag acccgcagga tcgacccgac
4325101 agcgagccga gcgacgcatc gacgccgcca gctaagaagc tgccggccaa gaaggccgcc
4325161 aagaaagcac cagcaagaaa gacgccggcg aagaaggcac ccgccaaaaa aacacccgcc
4325221 aagggtgcta agtccgcgcc accaaagcct gccgaggcgc ccgtcagttt gcagcagcgg
4325281 atcgaaacca acggccagct tgcagctgct gctaaggatg cagcggcaca agcaaagtcg
4325341 acagtggaag gcgccaacga cgccctggcg cgcaacgcat cagtgccggc gccgagtcac
4325401 tcgcccgtgc cgctgatcgt tgccgtcacg cttagcctgc tggcgctgct gctgatccgg
4325461 caactgcgcc gccgctgaac gcgctggcac catagtggcc atctcatttc gcccaaccgc
4325521 tgacctcgtc gacgacatcg ggcccgacgt gcgcagctgt gacctacagt tccgccaatt
4325581 cggcggccga tcgcagttcg ccggaccgat cagcaccgtg cggtgttttc aggacaatgc
4325641 gttgctgaag tcggtgctct cgcagccaag tgcgggcggt gtgctggtca tcgacggcgc
4325701 cgggtccctg cacaccgcgt tggtcggtga tgtcatcgcc gagttggccc gctctaccgg
4325761 ctggaccggg ttgatcgtcc acggcgcggt gcgagatgcc gccgcgctgc gcggcatcga
4325821 catcggcatc aaagcgctgg gcaccaatcc ccgcaagagc accaagaccg gtgccggaga
4325881 acgcgacgtt gaaatcacgc tgggcggggt gacattcgtt ccgggcgata tcgcctacag
4325941 cgacgacgac ggcatcatcg tcgtctgact atggcctaaa ccggcgctaa accgtcgcta
4326001 aagctaaacc cccaccgggg caggcctttt ggcgaaccgc agaccctcgt cgtcgatctt
4326061 gccgcgccgg atgagccgga tgtcacgtag gtagttctga ttcaggcgcc acggtgtacg
4326121 cgaaccctgc ttgggcagct cgtccagcga gcgcagcacg taacctgggg tgaactccat
4326181 gaagggccgc tcttcgacat ctgagcccgg tcgctcgacg accacggtgt caaaaccgtt
4326241 gtcgtccatg taattcaaca agcgacagac aaactccgac accaggtcgg ccttcagcgt
4326301 ccaggaggca ttggtgtagc caaccgtgta ggccatgttg gggatgccgg aaagcatcat
4326361 gcccttgtag gccatcgtcg tggtgatgtc cacttgttgt ccgtcgatag tcgccgtcgc
4326421 cccaccaaaa agctgcaggt tcaaccccgt tgcggtaatg atgatgtcag ccggcagttc
4326481 gcgacctgag ttcagccgga ttccggtcgc ggtgaaccgt tcaatggtgt cggtcaccac
4326541 ctcgaccttc ccgtgacgaa tggcccggaa caggtcgccg ttgggcacca agcacaatcg
4326601 ctggtcccag gggttgtagt gcgggccgaa gtgctttcgc acgtcgtacc cctcgggtag
4326661 ctggcgctgg atcaggctca ggaacatctt ccgcatgcgc cgtggccact tctggcaggc
4326721 gctgtacacg gccgcctggc gcagcacgtt cttccaccgt accgcggtgt aggccatggt
4326781 ctccggcagc cagcggttga gcttctcggc gatgccgtcc cggtctggct gcgacacgat
4326841 gtaggtgggt gagcgctgca gcatcgtgac gtgcttggcg cccgagtccg ccagcgccgg
4326901 cacgagcgtg accgccgttg cgccactgcc gatcacgacg atgttcttag cgtcgtagtc
4326961 gaggtcctcg ggccagtgct gcggatggat gatcggcccg acgaaatcct ccgagccggc
4327021 gaatctcggc gagtagccct cgtcgtagtt gtagtagccg ctgcacagaa agaggaattc
4327081 gcaggtgagg gcgctgagcg tgccgtggct ttggatgtga acggtccagc ggttttccgc
4327141 ggtcgaccaa tcggcactga tcaccttgtg gtggaaccgg atatgcctgt cgattccata
4327201 catggccgcg gtgctcttga cgtactcgag gatgggcttg ccgtcggcga tcgcctgccg
4327261 tccggtccag ggacggaatc ggaaacctag cgtgtacatg tcggagtcgg agcgaattcc
4327321 gggataacgg aacaaatccc aggtgccgcc catggattcc cgcttttcca ggatggcgta
4327381 gctcttggtc gggcaacggt cctgcaggtg ccaggccgcg ctgacaccgg agattccagc
4327441 gcccacgatg acaacgtcga ggtgctcggt catggatcca cgctatcaac gtaatgtcga
4327501 ggccgtcaac gagatgtcga cactatcgac acgtagtaag ctgccagggt gaccacctcc
4327561 gcggccagtc aggcttcgct gcctaggggc cggcgcaccg cgcggccgtc cggcgacgat
4327621 cgtgaactgg cgatcctcgc caccgccgag aaccttctcg aggaccgtcc gctggccgat
4327681 atctcggtcg acgatctggc caagggcgcc ggtatctcga ggccgacgtt ctacttctat
4327741 ttcccatcca aggaagcggt gctgctgacc ctgctggacc gggtggtcaa tcaagccgac
4327801 atggccctac agacccttgc cgagaatccc gccgacaccg accgcgagaa catgtggcgc
4327861 accgggatca acgtgttctt cgagacattc gggtcgcaca aggcggtaac ccgagccggt
4327921 caggccgcca gggcaaccag tgtcgaagtc gccgaactgt ggtcgacgtt tatgcagaag
4327981 tggatcgcct acacggccgc cgtgatcgac gccgaacgcg accgaggcgc ggcgccgcgc
4328041 accctgccgg cccatgaact ggccacagcg ctcaacctga tgaacgagcg gacgctgttc
4328101 gcgtcattcg ccggcgaaca gccctcggtg ccggaagccc gcgtgctgga tacgctggtg
4328161 cacatctggg tgaccagcat ttacggcgag aaccgctaag ccgcactcgg tcgggggtgc
4328221 tcggtcgatg ctcagtgcca aagcggcatg cagatctcac ggaggtccgg tggacgatct
4328281 ggcagccgaa gtggcgcctt gggtaggcaa tggcgtgcgg tcatatagga gcgggtgcat
4328341 tcgcatgtcg gacacgtggc gttgccgcct ggtaccgcgg tgttcgtggc cgacagcggg
4328401 ctaatgcgac ccggtccacg ccaggagcgt gtcggccggc caggtgttga cgatccggtc
4328461 ggcgggcacc tccgcgtcca aggcgcgctg ggcgccgtag ccgaggaagt ccagctggcc
4328521 gggtgcgtgc gcgtcggtgt cgatgctgaa cacgcagccg atgtcgcgcg ctaggtgcaa
4328581 caggcgcgtc ggtgggtctc ggcgttccgg acgggagttg atctccacgg cggtgccgtg
4328641 ctcacggcag gcggtgaaca ccgcctctgc atcgaacttc gattctggcc ggatgccacg
4328701 attgccggcg atcagccggc cggtgcagtg gcccagcacg tcggtgtgac cgttggccac
4328761 ggcgcgcacc atccgtcgcg tcatcgctgc cgaatccatc gacagcttgg agtgcacgct
4328821 ggccaccacg atgtcgaggc ggtccagcat ctcgggttcc tggtccaagc tcccgtcttc
4328881 gaggatgtcg acctcgatcc cggtcaggat gcgcagcggc gcgaacttct cgcgcagctc
4328941 gtcgatcacg tccagctgct tgcgcaaccg gtccggagac aggccgttgg cgatcgtcaa
4329001 ccgcggtgag tgatcggtca atgcgcagta ctggtgacct agcgccgccg cggtggccat
4329061 catctcctcg atcggcgcgg acccgtccga ccagttcgaa tgcagatgca gatccccgcg
4329121 caatgcggca cggatcgccc ctccaccgag atcctcagcg tcagcgcgta attcagccag
4329181 caggtccggc tcgcggccag accaggcctg ggcgatgact ttcgcggttt tgggaccgat
4329241 acccgccagc gactgccagc tgttggcctg gccgtgccgc tgccgcgccg cgtcgtcaag
4329301 gccctcgata atgtcggcgg cattgcgata ggccatcacc cgcctcgggt cgtggcggtt
4329361 ccggtccttg taataggcga tctgccgcag cgctgttacc gggtccatta tcgggctcac
4329421 accagttgcc cgaagacgac cccggtgaca accaccgcga agccggccat ttcgccgagg
4329481 atgagcaacg ccattaacac ccccgcaccc tttgcgggac gctcgaattg gttcgcggtg
4329541 gcacggcgcg cgccatgggt gacataactc gccaacagga tgggtttcgt atcaaatccg
4329601 agggcacagt tcatcgcttc actgagttta gttgggacct aggcccagat gccgtcgcgg
4329661 cctggggcgc cattgcccta gataacaatc tgataaagcg gagcaaacaa gctgtggtgc
4329721 acactcgggc acgtatcagg ttggctacac agcgaagcgc aacagctctt cagtggttat
4329781 cgggcgctcg ttcttggcgg ggaactcgtg gcttttgacc gggtggcgaa accatgacca
4329841 ggcgattcgc cccatccgtg accggggtac tgggttggta cgcacagcga cactcctgcg
4329901 atcggacaac tcgactggca cctcacatta aacctctatg tgacgaagcc cacatcgact
4329961 cattagacac ctcggagctg gcaaacagtg aacggcgcgc cgagcaatta tcaaatgttt
4330021 ctgatgtgac tctagtgatt attgaagcgg tgcagcggtc ggcttaacag gcgccggcag
4330081 ggcactggaa cccatcaagt accggtctac ggccgcggca gcggcccggc cctcggcaat
4330141 cgcccagacg atcaatgact ggccccggcc catgtcaccg gctacgaaca caccaggaac
4330201 cgaggtgtcg aagtcgtcgc cacgggccac gttcccacgc tcggtgaact tcactccgag
4330261 gtcggtcaac aggcccgccc gttccgggcc gacgaaaccc atcgccagca acaccaggtc
4330321 ggcttcgagc tcgaagtcgg agccctcaac cttgacgaac ttgccatcca gcatggtcac
4330381 ttcgtgtgcc cgcagcgcgc tcacgcgccc gtccgtgccg acgaacgcct cggtgttgac
4330441 cgagaacacc cgctcgccac cctcctcatg cgcggccgat acccgataca tcagcgggta
4330501 agtcggccat ggggtggatt cggcgcgggc gtccggtgga cgcggcatga tctcgaactg
4330561 gtgcacggcg atcgcgccct ggcggtgcac ggtacccagg cagtccgccc cggtgtcgcc
4330621 gccaccgatg atgacgacct tcttgccctt tgcggtgatc ggcggctgcc cgtcctcatc
4330681 gaggacgtca tctccttctt gcacccggtt ggcccacggc agaaactcca tcgcctgatg
4330741 gacgccctcc agctcgcggc cgggaatcgg cagctcgcgc caagcggttg cgccaccggc
4330801 caatacgacc gcatcgaaat cagcgcgcag cttttcggcg ctaatgtcga ccccgacgtt
4330861 gacgcccggc cggaattcgg ttccttcgga gcgcatttgg tccaaacgcc gatcaagatg
4330921 ccgcttttcc atcttgaatt ccgggatgcc gtaacgcagc agcccgccga tgcggtcttc
4330981 gcgctcgaaa acggtgacgg tgtgacccgc ccgggtgagt tgctgggcgg cggccaaacc
4331041 cgccggcccc gaacccacca cagcaaccgt ttgcccggtc agcttccgcg gcggacgtgg
4331101 ttgcacccat ccttcgtcga aggccttgtc gatgatctcc agctcgatct gcttgatcgt
4331161 caccggatcc tggttgatgc ccagcacaca cgccggctcg cacggagccg ggcacaaccg
4331221 gccggtgaag tcggggaagt tgttggtggc gtgcagccgt tcgattgcgt cgcgccagcg
4331281 gccccggcgg accagatcgt tccattccgg gatcaagtta cccagcggac atccgttgtg
4331341 acagaacgga atgccgcaat ccatgcagcg ggtcgcctgt tggcgcaggc tctcgttgtc
4331401 gaattcctcg tagacttccc gccagtctcg cagccgcagc gggaccggcc gtcgcttcgg
4331461 caatttccgg tgggtgtatt tgaggaagcc gcccggatca gccatgcgca gccgccatga
4331521 tcgccttgtc gacatcaacg ccgtcacgtt cagccagggc gatcgcctgc aggacccgtt
4331581 tgtagtcacg cggcatcacc ttgacgaagt ggcgctgctg tcccgaccag tcggacagaa
4331641 tccgctggcc gacagcggaa tcggtagcgt cgacgtgcac ttgtatggtg ccgtgcagcc
4331701 agtccgcgtc atcctcgtcg agggtctcga gttcgaccat ctccgagttg aggttggccg
4331761 gcagttcacc gtcgggatcg taaacatagg ccacaccgcc ggacataccc gccgcaaagt
4331821 tacggccggt gcggcccaga atgacaaccc tgccgccggt catgtactcg cagccgtgat
4331881 cgccgacacc ctctaccacg gcgtgggccc cggaattgcg caccgcgaac cgttcgccta
4331941 ccacaccgcg caggtaaacc tcgccactgg ttgcgccgaa cagaatcaca ttgcccccga
4332001 tgatgttgtc ctcggcgaca taatcctgcg gcgcgtcatc cgacggccgc accacaatcc
4332061 ggccaccgga tagccctttg ccgacgtagt cattggcgtc gccatacacc cgcaaggtaa
4332121 ttcccttggg cacgaaggct ccgaagctgt ttcccgcgga tccgtcgaac gtgatatcga
4332181 tggttccgtc cggcaagcct tggccgccat aggccttcgt cagctcgtgg ccgagcatgg
4332241 tgcccaccgt gcggttgaca ttgcctatgg tggtggagaa gcggaccggc ttgccggaat
4332301 ccagtgcttc cctgctcatc acgatcagct gctgatcgag cgccttgtct agaccgtgat
4332361 cctggcgcga actgcagtac agatcctgat tcatgaaggc cgactccggc tcgtggagca
4332421 ccggcgccag atccagctta tgcgccttcc agtgcgcgcg tgccagcgtg gtgtccagcg
4332481 cacctgcctg tccaaccgcc tcgttcacag tgcggaagcc caactgcgcc aaatattccc
4332541 ggacttcctc ggcgatgaac atgaagaagt tctccacgaa ctcgggcttc ccggtgaacc
4332601 gctcccggag caacggattc tgggtggcca caccaaccgg gcacgtgtcc aggtggcaca
4332661 cccgcatcat gatgcagccg gccactacca acggcgcggt cgcgaatccg aactcttctg
4332721 ccccgagcag cgtagcgatc atcacatcgc gacccgtctt gagctgaccg tccacctgga
4332781 ccacaattcg atcacgtaac ccgttgagca gcaacgtctg ctgtgtctca gccagaccca
4332841 actcccaggg tgctccggcg tgcttcatcg atgtcagcgg ggtcgcgccg gtgccaccat
4332901 cgtgccctga gatcaagacc acgtcggcgt gggctttgga aacgccagcc gcaaccgtcc
4332961 ctaccccgtt ttcggagacc agcttgacgt gtacccgcgc ggatggattg gcgttcttta
4333021 ggtcgtggat cagctgcgcc agatcctcaa tggagtagat gtcgtggtgg ggcggcggtg
4333081 agatcagacc gacaccgggc gtggagtgcc ggacctcggc cacccaaggg tacaccttgt
4333141 gccccggaag ctgacctccc tcaccaggtt tcgcgccctg cgccatcttg atctggaggt
4333201 cggtgcagtt ggtcaggtaa tgcgaggtga cgccaaaccg ggcggaggct acctgcttaa
4333261 tggcgcttcg gcgccaatcc ccgttggggt cgcggtcaaa tcgcttgacg tcctcgccgc
4333321 cttcaccaca gtttgaccgg gcaccaagcc ggttcattgc gatggccagc gtctcgtgcg
4333381 cttcagcgga aatcgagccg tagctcatcg cccccgttga gaagcgcttg acgatttcgc
4333441 tggccggctc gacctcgtcc agcgggactg gaggacgaac cccggtacgg aacttgagca
4333501 gaccacgcag cgatgccatc cgctcgctct ggtcgtcgac cagacgggtg tactccttga
4333561 agatcttgta ctggccggtt cgcgtggagt gctgcagctt gaacacagtc tccgggttga
4333621 acaggtggta ctcgccctcg cggcgccact ggtattcccc acccacctcg agttcgcggt
4333681 gagcgcgttc gtccggccgg tccagatagg ccagccggtg ccgggctgcg acatcggccg
4333741 cgatgtcatc cagggtgatc ccgccggtgg ggcaggtaag cccggtgaag tattcgtcga
4333801 gcacttgctc ggagatgccg acagcctgga acagttgcgc accggtgtag gaggccagcg
4333861 tcgagatgcc catcttcgac atcactttca gcacaccctt acctgcggct ttgatgtagt
4333921 tgttcagcgc cgccgtacgg tcgatgccct cgataacacc gcggtcgagc atgtcctcga
4333981 tcgactcgaa caccaggtag gggttgatcg cggccgcgcc gaatccgacc agcgcggcca
4334041 tgtggtgcac ctcgcgggca tcaccggact cgaccaccag acccacttgg gtgcgggtcc
4334101 gttcccgaac caggtggtgg tgcactcccg caacggcgag cagcgacggt atcggagcca
4334161 tttcctcgtc ggactcgcgg tcggacaaga tgatgatccg agcgccgtcg gcgattgccg
4334221 ccgccgccgc gccacgtacc tcttccagcg cggcagccag cccagcacct ccctcggaga
4334281 cccggtacag acagcgaatc accttggacc gcaatccgtg tgggcgccca ttgaccttgt
4334341 cgttgggatc gaggctgacc agcttggcga gctcgtggtt acgcagaatc ggctggggca
4334401 gcacgatctg gtggcaggag ttctggtccg ggttgagcaa gtcacgttcg ccgccggtgg
4334461 tgccctgcag gctggtcacc acctcctcgc ggatggcgtc caacggcggg ttggtcacct
4334521 gggcgaacag ctgatggaag tagtcgtaga gcatgcgcgg acgctgcgac aacaccgcaa
4334581 ctggagtgtc ggtgcccatc gacccgattg gctcggcacc gagccgagcc atcggcgcta
4334641 ccagcaggtt gagctcctcg taggtatagc cgaatgccaa ctgccgcatg acgattcgat
4334701 ggtggggcat ccgcacgtct ttgccctccg gcaattcgtc gagcggaact agtccgttgt
4334761 caagccactc ctgatacgga tgctcggccg ccaggtcggc cttgatctcc tcatcggaga
4334821 cgatgcggcc ctgcgcggtg tccaccaaga acatccggcc cggctgcagc cgcatccggc
4334881 gcaccaccgt cgacggatgc aggtccaaca caccggcctc ggaagccatc accaccaaac
4334941 cgtcgtcggt gacccagatt cgcgacgggc gtaggccatt gcggtccagc acggcgccca
4335001 cgacggtgcc gtcggtgaac gtcatcgacg ccgggccgtc ccacggctcc atcaacgagg
4335061 cgtgatactg gtaaaacgcc cgccgcgcgg ggtccatcga ctcgtggcgc tcccaggcct
4335121 cagggatcat catcagcacc gcgtgggcca ggctgcgtcc gcccaggtgc agcagttcga
4335181 gcacctcgtc gaagcgcgcg gtgtccgagg cacccggggt acagatcggg aacagctttt
4335241 cgacatcggc cgccgaccca aagatgtcgg tcttgatcag cgcctcgcgg gcccgcatcc
4335301 agttctcgtt accggtgacg gtgttgatct ccccgttgtg cgcgatccgc cggaatggat
4335361 gcgccagcgg ccaggacggg aaagtgttcg tggagaaccg cgagtgcacg atgcctagcg
4335421 cgctggtcag tcgctcgtcc tgcaaatcga ggtagaaggc cttgagctgc ggggtggtca
4335481 gcatgccctt gtagacgagc gtctggccgg acaggctcgg gaagtacacg gtttcccggc
4335541 ccggcccgtc ttgacccgga cccttggtgc cgagttcatg ctcggcccgc ttgcggacca
4335601 catagcagcg ccgctccaac gccatgccgg acgcgccagc caagaacacc tgccggaagg
4335661 tgggcatggc atcacgggac agcgcgccca gcgatgagtc gtcggtgggg acgctgcgcc
4335721 aacccaggac ttgcagcccc tcggcctcgg cgattttctg tacggcggcg caggccgcgg
4335781 cggcgtcttt agatgactgc ggcaagaacg cgatacccgt ggcatagctg cctggggcag
4335841 gcaactcgaa atccacggct tcgcgaagga attcgtccgg aacctgaatc aggatgcccg
4335901 cgccgtcacc gctgcggggt tcggcgcctt gcgcgccccg atgctcgagg ttgagcaggg
4335961 cggtgatcgc cttgtccacg atgtcgcggc tacgacggcc gtgcatgtcc acaaccatgg
4336021 caaccccgca cgaatcgtgt tcgaacgcgg ggttatacaa cccgacgcgc ttaggcgtca
4336081 tacccaccta acccttcagc agactttctg cgcggccgcc tttgcggatt cgacggggcc
4336141 gcacccggag gtagcgggca agaccccttc ggtcttgtcg ataggctgtc cgtcaagcgg
4336201 gcgtgatccg gtcggggctt cgtccgtgca gcagtgaacg cttggccctg gaatcggact
4336261 cgacaagtcg taaaacgata tgacaaaacc cgcttgacat gccaactttc ccaatactaa
4336321 ctcgtcagcc ggcggcaccg tagctgccgc gtggccagca accgaccgta tcgtcacatg
4336381 catttttcct cgtccaaatc cggctgcgct agctgcgtgg cggtctgatc gccagccaca
4336441 ggaaatgctt agatacgttt gctgtgaaat ccggagcacc gctgtttcgc cacttgcgcc
4336501 ggtgggaaca accgccggaa cggcgggtat ctgtgttgtt gcatggcgat gccgccgcga
4336561 cgactaccca gcgcaacccc ccagagtttg cgcgatccta aaaggggtct aaaaagggcg
4336621 tctagacagc cagcagtcag tccagggagc tagccgatac gggacgatat tggtcggcgt
4336681 ccggcatggg cgatcttacc gtggggctca tcagccgcga gctcgcctca gccggccacc
4336741 ggcgcgacaa tcgatcgcct gtcacctgag gagcttatgt acgagcgtga cgaattcctg
4336801 cgcgatcgga tccgaccaca ccagcccggc accccgcggg gatactcgcc ccgtccgccg
4336861 tccggagatc gctgccccgc gccaccgcct ggccggcacg ctgctgccgc tacgccacca
4336921 gggccgccgc gcctgccttc agctccactg cgtccattgc cggacccggc ttggccacgc
4336981 cagccggagg ccccgccacc gagcacctgg gccgaccccg ccctggcgcc gatacgcagt
4337041 cggacgcgac ccggcgagcg tggttggcga cgcatggtgc ggctggtcac ctttggcctt
4337101 gtcggcctgg gccggtcggg catgcagcgc caggaggccc aattcgaagc aacgatacga
4337161 accgtcctgc atggcaacca caaggtcgcc gtgctgggca aaggaggtgt gggaaagacg
4337221 tcggttgcgg cgtgcgtcgg atcgatcctt gccgaactgc gccagcagga ccgtatcgtc
4337281 gggatcgacg ccgacaccgc cttcggcagg ctgagcagcc gaatcgatcc tcgagcagct
4337341 ggttcgttct gggagctgac caccgacacg aatctgcggt ccttcaccga tatcaccgcg
4337401 cgcctgggcc gaaattccgc gggactgtac gtcctggcag gccagccggc atccggtccg
4337461 cgccgggtgc tcgatccggc catctaccgc gaagccgccc taaggttgga tcaccatttc
4337521 gcaatctcgg tgatcgactg cggttcctcc atggaggcgg cggtcaccca ggaagtattg
4337581 cgcgatgtgg atgctctgat cgtggtgtcc tcgccctggg cggatggtgc ctccgctgcc
4337641 gccaacacca tcgaatggct gtcggattat ggcctgacag gtttgttgcg acgcagcatc
4337701 gtggtgctca acgattcgga cggacacgcc gacaagcgca ccaagtcatt gctggcccag
4337761 gaattcatcg accacgggca gcctgtggtc gaggtgccct tcgatcccca tttgcggccc
4337821 gggggggtca tcgatatgag ccacgaaatg gccccgacga cgcggctgaa aatcctgcag
4337881 gtcgccgcga cggtgacggc gtacttcgcg tcgcgacccg ccgacgcaca cggcagcccg
4337941 ccccggtgac ctggctggct gacccggtcg gcaacagcag gatcgcccga gcgcaggcct
4338001 gcaaaacgtc aatctcggcg cccatcgtcg aatcctggcg ggcgcaacgc ggcgcgcaat
4338061 gtggacagcg cgagaaatct tgtcgatgtt ctcgcgctgt ccacatccag ggcatctcac
4338121 cgccactgtt ccgcagaccc ctcgaaccag cggtccaggc ggcggttgcg tcatgccgat
4338181 tgggcagaca cccggtggtc gcgcaccggg taaccgttgc gctcggccag ggatcgcagc
4338241 tggcccaacg cgaatgcccg cgcccggcct gattcgggaa ttacgacccc tgcccacagc
4338301 ccttccgcac ccgcggactc gacggcgtcg cgtgcacaca gccaccggcg cgggcaagcc
4338361 cggcacaggg tcttggcctc gtcgtcggga gtcgtcgtcc aacgatcggg atcttgcgtg
4338421 caaacgccga gcgggacctc atacagggcg gttactgtca tgtctacgtt cctccagaaa
4338481 gcgttgcagg ttgtagcctc tgccgcgaaa gcgtatcgca ttaaccatag cgatgcaaca
4338541 gtttcctcct ctgcctgcct agcggtgctg cggctccggt tcggcgagct ccgagctcta
4338601 gtgcgcgcac cgccgagtac cagggcatag atcctgttaa tcagctgtgt atctggcctc
4338661 gccggcgcgt atccgacccc ttcgggcaga tcttccagga aaagtgttct gacatgcgac
4338721 agttcaggtg tgaagtgaac tgtagcggca gttcggtttg gctaggaaac tatttccata
4338781 gcgggccgtc gcgtcgctag atccaaaatg tagcgaagtc atagcagtag aagggtgcaa
4338841 cggttaggat ggcgggcgag cggaaagtct gcccaccgtc ccggctagta cccgcgaata
4338901 agggatcaac gcagatgtct aaagcagggt cgactgtcgg accggcgccg ctggtcgcgt
4338961 gcagcggcgg cacatcagac gtgattgagc cccgtcgcgg tgtcgcgatc attggccact
4339021 cgtgccgagt cggcacccag atcgacgatt ctcgaatctc tcagacacat ctgcgagcgg
4339081 tatccgatga tggacggtgg cggatcgtcg gcaacatccc gagaggtatg ttcgtcggcg
4339141 gacgacgcgg cagctcggtg accgtcagcg ataagaccct aatccgattc ggcgatcccc
4339201 ctggaggcaa ggcgttgacg ttcgaagtcg tcaggccgtc ggattccgct gcacagcacg
4339261 gccgcgtaca accatcagcg gacctgtcgg acgacccggc gcacaacgct gcgccggtcg
4339321 caccggaccc cggcgtggtt cgcgcagggg cggccgcggc tgcgcgccgt cgtgaacttg
4339381 acatcagcca acgcagcttg gcggccgacg ggatcatcaa cgcgggcgcg ctcatcgcgt
4339441 tcgagaaagg ccgtagttgg ccccgggaac ggacccgggc aaaactcgaa gaagtgctgc
4339501 agtggcccgc tggaaccatc gcgcgaatcc gtcggggcga gcccaccgag cccgcaacaa
4339561 accccgacgc gtcccccgga ctccggcctg ccgacggccc ggcgtccttg atcgcgcagg
4339621 ctgtcaccgc cgccgtagac ggctgcagtc tggctatcgc agcgttgccg gcgaccgagg
4339681 accccgagtt caccgaacgt gccgcgccga tccttgctga tttgcgccag ctcgaggcga
4339741 ttgccgtcca agcaacccgc atcagccgga ttaccccgga attgatcaag gcgttgggcg
4339801 cggtacgtcg ccaccacgac gaattaatga ggctgggagc aaccgcccct ggtgccacac
4339861 tggcgcagcg cttatatgcc gcacggcggc gcgcgaacct ttccaccctg gagactgccc
4339921 aagcggccgg cgtcgcagaa gaaatgatcg tcggcgccga agccgaggaa gagttgccag
4339981 ccgaggccac cgaagcgatc gaagcactga tccgtcagat caattgaggt cggctccgag
4340041 cgtcccacaa gtacaggcac gccgtaacgc tcaagttcaa cggtccgggg aacgcgcgcg
4340101 ttctccggcg tttgacggtg cgttccatcg tgccgcgaac ttgaaaacgc cagcgtcacc
4340161 aaaaaattcg tgcaccaacc cccctccgag cgctgctaag ctcaatgtgc agtgcaaagg
4340221 tgcagataat gatggcgcac cggaacggcg agcgtaagga aacacataaa tggcatcggg
4340281 tagcggtctt tgcaagacga cgagtaactt tatttggggc cagttactct tgcttggaga
4340341 gggaatcccc gacccaggcg acattttcaa caccggttcg tcgctgttca aacaaatcag
4340401 cgacaaaatg ggactcgcca ttccgggcac caactggatc ggccaagcgg cggaagctta
4340461 cctaaaccag aacatcgcgc aacaacttcg cgcacaggtg atgggcgatc tcgacaaatt
4340521 aaccggcaac atgatctcga atcaggccaa atacgtctcc gatacgcgcg acgtcctgcg
4340581 ggccatgaag aagatgattg acggtgtcta caaggtttgt aagggcctcg aaaagattcc
4340641 gctgctcggc cacttgtggt cgtgggagct cgcaatccct atgtccggca tcgcgatggc
4340701 cgttgtcggc ggcgcattgc tctatctaac gattatgacg ctgatgaatg cgaccaacct
4340761 gaggggaatt ctcggcaggc tgatcgagat gttgacgacc ttgccaaagt tccccggcct
4340821 gcccgggttg cccagcctgc ccgacatcat cgacggcctc tggccgccga agttgcccga
4340881 cattccgatc cccggcctgc ccgacatccc gggcctaccc gacttcaaat ggccgcccac
4340941 ccccggcagc ccgttgttcc ccgacctccc gtcgttccca gggttccccg ggttcccgga
4341001 gttccccgcc atccccgggt tccccgcact gcccgggttg cccagcattc ccaacttgtt
4341061 ccccggcttg ccgggtctgg gcgacctgct gcccggcgta ggcgatttgg gcaagttacc
4341121 cacctggact gagctggccg ctttgcctga cttcttgggc ggcttcgccg gcctgcccag
4341181 cttgggtttt ggcaatctgc tcagctttgc cagtttgccc accgtgggtc aggtgaccgc
4341241 caccatgggt cagctgcaac agctcgtggc ggccggcggt ggccccagcc aactggccag
4341301 catgggcagc caacaagcgc aactgatctc gtcgcaggcc cagcaaggag gccagcagca
4341361 cgccaccctc gtgagcgaca agaaggaaga cgaggaaggc gtggccgagg cggagcgtgc
4341421 acccatcgac gctggcaccg cggccagcca acgggggcag gaggggaccg tcctttgatc
4341481 ggacaccgag tcgccagcag gtctgtgcca tagcgagtcg aagccatagc gagtagaaag
4341541 ttaaacgtag aggagggttc aacccatgac cggatttctc ggtgtcgtgc cttcgttcct
4341601 gaaggtgctg gcgggcatgc acaacgagat cgtgggtgat atcaaaaggg cgaccgatac
4341661 ggtcgccggg attagcggac gagttcagct tacccatggt tcgttcacgt cgaaattcaa
4341721 tgacacgctg caagagtttg agaccacccg tagcagcacg ggcacgggtt tgcagggagt
4341781 caccagcgga ctggccaata atctgctcgc agccgccggc gcctacctca aggccgacga
4341841 tggcctagcc ggtgttatcg acaagatttt cggttgatca tgacgggtcc gtccgctgca
4341901 ggccgcgcgg gcaccgccga caacgtggtc ggcgtcgagg taaccatcga cggcatgttg
4341961 gtgatcgccg atcggttaca cctggttgat ttccctgtca cgcttgggat tcggccgaat
4342021 atcccgcaag aggatctgcg agacatcgtc tgggaacagg tgcagcgtga cctcacagcg
4342081 caaggggtgc tcgacctcca cggggagccc caaccgacgg tcgcggagat ggtcgaaacc
4342141 ctgggcaggc cagatcggac cttggagggt cgctggtggc ggcgcgacat tggcggcgtc
4342201 atggtgcgct tcgtcgtgtg ccgcaggggc gaccgccatg tgatcgcggc gcgcgacggc
4342261 gacatgctgg tgctgcagtt ggtggcgccg caggtcggct tggcgggcat ggtgacagcg
4342321 gtgctggggc ccgccgaacc cgccaacgtc gaacccctga cgggtgtggc aaccgagcta
4342381 gccgaatgca caaccgcgtc ccaattgacg caatacggta tcgcaccggc ctcggcccgc
4342441 gtctatgccg agatcgtggg taacccgacc ggctgggtgg agatcgttgc cagccaacgc
4342501 caccccggcg gcaccacgac gcagaccgac gccgccgctg gcgtcctgga ctccaagctc
4342561 ggtaggctgg tgtcgcttcc ccgccgtgtt ggaggcgacc tgtacggaag cttcctgccc
4342621 ggcactcagc agaacttgga gcgtgcgctg gacggcttgc tagagctgct ccctgcgggc
4342681 gcttggctag atcacacctc agatcacgca caagcctcct cccgaggctg acccctcaca
4342741 tctccgctac gacttcagaa agggacgcca tggtggaccc gccgggcaac gacgacgacc
4342801 acggtgatct cgacgccctc gatttctccg ccgcccacac caacgaggcg tcgccgctgg
4342861 acgccttaga cgactatgcg ccggtgcaga ccgatgacgc cgaaggcgac ctggacgccc
4342921 tccatgcgct caccgaacgc gacgaggagc cggagctgga gttgttcacg gtgaccaacc
4342981 ctcaagggtc ggtgtcggtc tcaaccctga tggacggcag aatccagcac gtcgagctga
4343041 cggacaaggc gaccagcatg tccgaagcgc agctggccga cgagatcttc gttattgccg
4343101 atctggcccg ccaaaaggcg cgggcgtcgc agtacacgtt catggtggag aacatcggtg
4343161 aactgaccga cgaagacgca gaaggcagcg ccctgctgcg ggaattcgtg gggatgaccc
4343221 tgaatctgcc gacgccggaa gaggctgccg cagccgaagc cgaagtgttc gccacccgct
4343281 acgatgtcga ctacacctcc cggtacaagg ccgatgactg atcgcttggc cagtctgttc
4343341 gaaagcgccg tcagcatgtt gccgatgtcg gaggcgcggt cgctagatct gttcaccgag
4343401 atcaccaact acgacgaatc cgcttgcgac gcatggatcg gccggatccg gtgtggggac
4343461 accgaccggg tgacgctgtt tcgcgcctgg tattcgcgcc gcaatttcgg acagttgtcg
4343521 ggatcggtcc agatctcgat gagcacgtta aacgccagga ttgccatcgg ggggctgtac
4343581 ggcgatatca cctacccggt cacctcgccg ctagcgatca ccatgggctt tgccgcatgc
4343641 gaggcagcgc aaggcaatta cgccgacgcc atggaggcct tagaggccgc cccggtcgcg
4343701 ggttccgagc acctggtggc gtggatgaag gcggttgtct acggcgcggc cgaacgctgg
4343761 accgacgtga tcgaccaggt caagagtgct gggaaatggc cggacaagtt tttggccggc
4343821 gcggccggtg tggcgcacgg ggttgccgcg gcaaacctgg ccttgttcac cgaagccgaa
4343881 cgccgactca ccgaggccaa cgactcgccc gccggtgagg cgtgtgcgcg cgccatcgcc
4343941 tggtatctgg cgatggcacg gcgcagccag ggcaacgaaa gcgccgcggt ggcgctgctg
4344001 gaatggttac agaccactca ccccgagccc aaagtggctg cggcgctgaa ggatccctcc
4344061 taccggctga agacgaccac cgccgaacag atcgcatccc gcgccgatcc ctgggatccg
4344121 ggcagtgtcg tgaccgacaa ctccggccgg gagcggctgc tcgccgaggc ccaagccgaa
4344181 ctcgaccgcc aaattgggct cacccgggtt aaaaatcaga ttgaacgcta ccgcgcggcg
4344241 acgctgatgg cccgggtccg cgccgccaag ggtatgaagg tcgcccagcc cagcaagcac
4344301 atgatcttca ccggaccgcc cggtaccggc aagaccacga tcgcgcgggt ggtggccaat
4344361 atcctggccg gcttaggcgt cattgccgaa cccaaactcg tcgagacgtc gcgcaaggac
4344421 ttcgtcgccg agtacgaggg gcaatcggcg gtcaagaccg ctaagacgat cgatcaggcg
4344481 ctgggcgggg tgcttttcat cgacgaggct tatgcgctgg tgcaggaaag agacggccgc
4344541 accgatccgt tcggtcaaga ggcgctggac acgctgctgg cgcggatgga gaacgaccgg
4344601 gaccggctgg tggtgatcat cgccgggtac agctccgaca tagatcggct gctggaaacc
4344661 aacgagggtc tgcggtcgcg gttcgccact cgcatcgagt tcgacaccta ttcccccgag
4344721 gaactcctcg agatcgccaa cgtcattgcc gctgctgatg attcggcgtt gaccgcagag
4344781 gcggccgaga actttcttca ggccgccaag cagttggagc agcgcatgtt gcgcggccgg
4344841 cgcgccctgg acgtcgccgg caacggtcgg tatgcgcgcc agctggtgga ggccagcgag
4344901 caatgccggg acatgcgtct agcccaggtc ctcgatatcg acaccctcga cgaagaccgg
4344961 cttcgcgaga tcaacggctc agatatggcg gaggctatcg ccgcggtgca cgcacacctc
4345021 aacatgagag aatgaactat ggggcttcgc ctcaccacca aggttcaggt tagcggctgg
4345081 cgttttctgc tgcgccggct cgaacacgcc atcgtgcgcc gggacacccg gatgtttgac
4345141 gacccgctgc agttctacag ccgctcgatc gctcttggca tcgtcgtcgc ggtcctgatt
4345201 ctggcgggtg ccgcgctgct ggcgtacttc aaaccacaag gcaaactcgg cggcaccagc
4345261 ctgttcaccg accgcgcgac caaccagctt tacgtgctgc tgtccggaca gttgcatccg
4345321 gtctacaacc tgacttcggc gcggctggtg ctgggcaatc cggccaaccc ggccaccgtg
4345381 aagtcctccg aactgagcaa gctgccgatg ggccagaccg ttggaatccc cggcgccccc
4345441 tacgccacgc ctgtttcggc gggcagcacc tcgatctgga ccctatgcga caccgtcgcc
4345501 cgagccgact ccacttcccc ggtagtgcag accgcggtca tcgcgatgcc gttggagatc
4345561 gatgcttcga tcgatccgct ccagtcacac gaagcggtgc tggtgtccta ccagggcgaa
4345621 acctggatcg tcacaactaa gggacgccac gccatagatc tgaccgaccg cgccctcacc
4345681 tcgtcgatgg ggataccggt gacggccagg ccaaccccga tctcggaggg catgttcaac
4345741 gcgctgcctg atatggggcc ctggcagctg ccgccgatac cggcggcggg cgcgcccaat
4345801 tcgcttggcc tacctgatga tctagtgatc ggatcggtct tccagatcca caccgacaag
4345861 ggcccgcaat actatgtggt gctgcccgac ggcatcgcgc aggtcaacgc gacaaccgct
4345921 gcggcgctgc gcgccaccca ggcgcacggg ctggtcgcgc caccggcaat ggtgcccagt
4345981 ctggtcgtca gaatcgccga acgggtatac ccctcaccgc tacccgatga accgctcaag
4346041 atcgtgtccc ggccgcagga tcccgcgctg tgctggtcat ggcaacgcag cgccggcgac
4346101 cagtcgccgc agtcaacggt gctgtccggc cggcatctgc cgatatcgcc ctcagcgatg
4346161 aacatgggga tcaagcagat ccacgggacg gcgaccgttt acctcgacgg cggaaaattc
4346221 gtggcactgc aatcccccga tcctcgatac accgaatcga tgtactacat cgatccacag
4346281 ggcgtgcgtt atggggtgcc taacgcggag acagccaagt cgctgggcct gagttcaccc
4346341 caaaacgcgc cctgggagat cgttcgtctc ctggtcgacg gtccggtgct gtcgaaagat
4346401 gccgcactgc tcgagcacga cacgctgccc gctgacccta gcccccgaaa agttcccgcc
4346461 ggagcctccg gagccccctg atgacgacca agaagttcac tcccaccatt acccgtggcc
4346521 cccggttgac cccgggcgag atcagcctca cgccgcccga tgacctgggc atcgacatcc
4346581 caccgtcggg cgtccaaaag atccttccct acgtgatggg tggcgccatg ctcggcatga
4346641 tcgccatcat ggtggccggc ggcaccaggc agctgtcgcc gtacatgttg atgatgccgc
4346701 tgatgatgat cgtgatgatg gtcggcggtc tggccggtag caccggtggt ggcggcaaga
4346761 aggtgcccga aatcaacgcc gaccgcaagg agtacctgcg gtatttggca ggactacgca
4346821 cccgagtgac gtcctcggcc acctctcagg tggcgttctt ctcctaccac gcaccgcatc
4346881 ccgaggatct gttgtcgatc gtcggcaccc aacggcagtg gtcccggccg gccaacgccg
4346941 acttctatgc ggccacccga atcggtatcg gtgaccagcc ggcggtggat cgattattga
4347001 agccggccgt cggcggggag ttggccgccg ccagcgcagc acctcagccg ttcctggagc
4347061 cggtcagtca tatgtgggtg gtcaagtttc tacgaaccca tggattgatc catgactgcc
4347121 cgaaactgct gcaactccgt acctttccga ctatcgcgat cggcggggac ttggcggggg
4347181 cagccggcct gatgacggcg atgatctgtc acctagccgt gttccaccca ccggacctgc
4347241 tgcagatccg ggtgctcacc gaggaacccg acgaccccga ctggtcctgg ctcaaatggc
4347301 ttccgcacgt acagcaccag accgaaaccg atgcggccgg gtccacccgg ctgatcttca
4347361 cgcgccagga aggtctgtcg gacctggccg cgcgcgggcc acacgcaccc gattcgcttc
4347421 ccggcggccc ctacgtagtc gtcgtcgacc tgaccggcgg caaggctgga ttcccgcccg
4347481 acggtagggc cggtgtcacg gtgatcacgt tgggcaacca tcgcggctcg gcctaccgca
4347541 tcagggtgca cgaggatggg acggctgatg accggctccc taaccaatcg tttcgccagg
4347601 tgacatcggt caccgatcgg atgtcgccgc agcaagccag ccgtatcgcg cgaaagttgg
4347661 ccggatggtc catcacgggc accatcctcg acaagacgtc gcgggtccag aagaaggtgg
4347721 ccaccgactg gcaccagctg gtcggtgcgc aaagtgtcga ggagataaca ccttcccgct
4347781 ggaggatgta caccgacacc gaccgtgacc ggctaaagat cccgtttggt catgaactaa
4347841 agaccggcaa cgtcatgtac ctggacatca aagagggcgc ggaattcggc gccggaccgc
4347901 acggcatgct catcgggacc acggggtctg ggaagtccga attcctgcgc accctgatcc
4347961 tgtcgctggt ggcaatgact catccagatc aggtgaatct cctgctcacc gacttcaaag
4348021 gtggttcaac cttcctggga atggaaaagc ttccgcacac tgccgctgtc gtcaccaaca
4348081 tggccgagga agccgagctc gtcagccgga tgggcgaggt gttgaccgga gaactcgatc
4348141 ggcgccagtc gatcctccga caggccggga tgaaagtcgg cgcggccgga gccctgtccg
4348201 gcgtggccga atacgagaag taccgcgaac gcggtgccga cctacccccg ctgccaacgc
4348261 ttttcgtcgt cgtcgacgag ttcgccgagc tgttgcagag tcacccggac ttcatcgggc
4348321 tgttcgaccg gatctgccgc gtcgggcggt cgctgagggt ccatctgctg ctggctaccc
4348381 agtcgctgca gaccggcggt gttcgcatcg acaaactgga gccaaacctg acatatcgaa
4348441 tcgcattgcg caccaccagc tctcatgaat ccaaggcggt aatcggcaca ccggaggcgc
4348501 agtacatcac caacaaggag agcggtgtcg ggtttctccg ggtcggcatg gaagacccgg
4348561 tcaagttcag caccttctac atcagtgggc catacatgcc gccggcggca ggcgtcgaaa
4348621 ccaatggtga agccggaggg cccggtcaac agaccactag acaagccgcg cgcattcaca
4348681 ggttcaccgc ggcaccggtt ctcgaggagg cgccgacacc gtgacccgcg ccggcgacga
4348741 tgcaaagcgc agcgatgagg aggagcggcg ccaacggccc gcgccggcga cgatgcaaag
4348801 cgcagcgatg aggaggagcg gcgcgcatga ctgctgaacc ggaagtacgg acgctgcgcg
4348861 aggttgtgct ggaccagctc ggcactgctg aatcgcgtgc gtacaagatg tggctgccgc
4348921 cgttgaccaa tccggtcccg ctcaacgagc tcatcgcccg tgatcggcga caacccctgc
4348981 gatttgccct ggggatcatg gatgaaccgc gccgccatct acaggatgtg tggggcgtag
4349041 acgtttccgg ggccggcggc aacatcggta ttgggggcgc acctcaaacc gggaagtcga
4349101 cgctactgca gacgatggtg atgtcggccg ccgccacaca ctcaccgcgc aacgttcagt
4349161 tctattgcat cgacctaggt ggcggcgggc tgatctatct cgaaaacctt ccacacgtcg
4349221 gtggggtagc caatcggtcc gagcccgaca aggtcaaccg ggtggtcgca gagatgcaag
4349281 ccgtcatgcg gcaacgggaa accaccttca aggaacaccg agtgggctcg atcgggatgt
4349341 accggcagct gcgtgacgat ccaagtcaac ccgttgcgtc cgatccatac ggcgacgtct
4349401 ttctgatcat cgacggatgg cccggttttg tcggcgagtt ccccgacctt gaggggcagg
4349461 ttcaagatct ggccgcccag gggctggcgt tcggcgtcca cgtcatcatc tccacgccac
4349521 gctggacaga gctgaagtcg cgtgttcgcg actacctcgg caccaagatc gagttccggc
4349581 ttggtgacgt caatgaaacc cagatcgacc ggattacccg cgagatcccg gcgaatcgtc
4349641 cgggtcgggc agtgtcgatg gaaaagcacc atctgatgat cggcgtgccc aggttcgacg
4349701 gcgtgcacag cgccgataac ctggtggagg cgatcaccgc gggggtgacg cagatcgctt
4349761 cccagcacac cgaacaggca cctccggtgc gggtcctgcc ggagcgtatc cacctgcacg
4349821 aactcgaccc gaacccgccg ggaccagagt ccgactaccg cactcgctgg gagattccga
4349881 tcggcttgcg cgagacggac ctgacgccgg ctcactgcca catgcacacg aacccgcacc
4349941 tactgatctt cggtgcggcc aaatcgggca agacgaccat tgcccacgcg atcgcgcgcg
4350001 ccatttgtgc ccgaaacagt ccccagcagg tgcggttcat gctcgcggac taccgctcgg
4350061 gcctgctgga cgcggtgccg gacacccatc tgctgggcgc cggcgcgatc aaccgcaaca
4350121 gcgcgtcgct agacgaggcc gttcaagcac tggcggtcaa cctgaagaag cggttgccgc
4350181 cgaccgacct gacgacggcg cagctacgct cgcgttcgtg gtggagcgga tttgacgtcg
4350241 tgcttctggt cgacgattgg cacatgatcg tgggtgccgc cggggggatg ccgccgatgg
4350301 caccgctggc cccgttattg ccggcggcgg cagatatcgg gttgcacatc attgtcacct
4350361 gtcagatgag ccaggcttac aaggcaacca tggacaagtt cgtcggcgcc gcattcgggt
4350421 cgggcgctcc gacaatgttc ctttcgggcg agaagcagga attcccatcc agtgagttca
4350481 aggtcaagcg gcgcccccct ggccaggcat ttctcgtctc gccagacggc aaagaggtca
4350541 tccaggcccc ctacatcgag cctccagaag aagtgttcgc agcaccccca agcgccggtt
4350601 aagattattt cattgccggt gtagcaggac ccgagctcag cccggtaatc gagttcgggc
4350661 aatgctgacc atcgggtttg tttccggcta taaccgaacg gtttgtgtac gggatacaaa
4350721 tacagggagg gaagaagtag gcaaatggaa aaaatgtcac atgatccgat cgctgccgac
4350781 attggcacgc aagtgagcga caacgctctg cacggcgtga cggccggctc gacggcgctg
4350841 acgtcggtga ccgggctggt tcccgcgggg gccgatgagg tctccgccca agcggcgacg
4350901 gcgttcacat cggagggcat ccaattgctg gcttccaatg catcggccca agaccagctc
4350961 caccgtgcgg gcgaagcggt ccaggacgtc gcccgcacct attcgcaaat cgacgacggc
4351021 gccgccggcg tcttcgccga ataggccccc aacacatcgg agggagtgat caccatgctg
4351081 tggcacgcaa tgccaccgga gctaaatacc gcacggctga tggccggcgc gggtccggct
4351141 ccaatgcttg cggcggccgc gggatggcag acgctttcgg cggctctgga cgctcaggcc
4351201 gtcgagttga ccgcgcgcct gaactctctg ggagaagcct ggactggagg tggcagcgac
4351261 aaggcgcttg cggctgcaac gccgatggtg gtctggctac aaaccgcgtc aacacaggcc
4351321 aagacccgtg cgatgcaggc gacggcgcaa gccgcggcat acacccaggc catggccacg
4351381 acgccgtcgc tgccggagat cgccgccaac cacatcaccc aggccgtcct tacggccacc
4351441 aacttcttcg gtatcaacac gatcccgatc gcgttgaccg agatggatta tttcatccgt
4351501 atgtggaacc aggcagccct ggcaatggag gtctaccagg ccgagaccgc ggttaacacg
4351561 cttttcgaga agctcgagcc gatggcgtcg atccttgatc ccggcgcgag ccagagcacg
4351621 acgaacccga tcttcggaat gccctcccct ggcagctcaa caccggttgg ccagttgccg
4351681 ccggcggcta cccagaccct cggccaactg ggtgagatga gcggcccgat gcagcagctg
4351741 acccagccgc tgcagcaggt gacgtcgttg ttcagccagg tgggcggcac cggcggcggc
4351801 aacccagccg acgaggaagc cgcgcagatg ggcctgctcg gcaccagtcc gctgtcgaac
4351861 catccgctgg ctggtggatc aggccccagc gcgggcgcgg gcctgctgcg cgcggagtcg
4351921 ctacctggcg caggtgggtc gttgacccgc acgccgctga tgtctcagct gatcgaaaag
4351981 ccggttgccc cctcggtgat gccggcggct gctgccggat cgtcggcgac gggtggcgcc
4352041 gctccggtgg gtgcgggagc gatgggccag ggtgcgcaat ccggcggctc caccaggccg
4352101 ggtctggtcg cgccggcacc gctcgcgcag gagcgtgaag aagacgacga ggacgactgg
4352161 gacgaagagg acgactggtg agctcccgta atgacaacag acttcccggc cacccgggcc
4352221 ggaagacttg ccaacatttt ggcgaggaag gtaaagagag aaagtagtcc agcatggcag
4352281 agatgaagac cgatgccgct accctcgcgc aggaggcagg taatttcgag cggatctccg
4352341 gcgacctgaa aacccagatc gaccaggtgg agtcgacggc aggttcgttg cagggccagt
4352401 ggcgcggcgc ggcggggacg gccgcccagg ccgcggtggt gcgcttccaa gaagcagcca
4352461 ataagcagaa gcaggaactc gacgagatct cgacgaatat tcgtcaggcc ggcgtccaat
4352521 actcgagggc cgacgaggag cagcagcagg cgctgtcctc gcaaatgggc ttctgacccg
4352581 ctaatacgaa aagaaacgga gcaaaaacat gacagagcag cagtggaatt tcgcgggtat
4352641 cgaggccgcg gcaagcgcaa tccagggaaa tgtcacgtcc attcattccc tccttgacga
4352701 ggggaagcag tccctgacca agctcgcagc ggcctggggc ggtagcggtt cggaggcgta
4352761 ccagggtgtc cagcaaaaat gggacgccac ggctaccgag ctgaacaacg cgctgcagaa
4352821 cctggcgcgg acgatcagcg aagccggtca ggcaatggct tcgaccgaag gcaacgtcac
4352881 tgggatgttc gcatagggca acgccgagtt cgcgtagaat agcgaaacac gggatcgggc
4352941 gagttcgacc ttccgtcggt ctcgcccttt ctcgtgttta tacgtttgag cgcactctga
4353001 gaggttgtca tggcggccga ctacgacaag ctcttccggc cgcacgaagg tatggaagct
4353061 ccggacgata tggcagcgca gccgttcttc gaccccagtg cttcgtttcc gccggcgccc
4353121 gcatcggcaa acctaccgaa gcccaacggc cagactccgc ccccgacgtc cgacgacctg
4353181 tcggagcggt tcgtgtcggc cccgccgccg ccacccccac ccccacctcc gcctccgcca
4353241 actccgatgc cgatcgccgc aggagagccg ccctcgccgg aaccggccgc atctaaacca
4353301 cccacacccc ccatgcccat cgccggaccc gaaccggccc cacccaaacc acccacaccc
4353361 cccatgccca tcgccggacc cgaaccggcc ccacccaaac cacccacacc tccgatgccc
4353421 atcgccggac ctgcacccac cccaaccgaa tcccagttgg cgccccccag accaccgaca
4353481 ccacaaacgc caaccggagc gccgcagcaa ccggaatcac cggcgcccca cgtaccctcg
4353541 cacgggccac atcaaccccg gcgcaccgca ccagcaccgc cctgggcaaa gatgccaatc
4353601 ggcgaacccc cgcccgctcc gtccagaccg tctgcgtccc cggccgaacc accgacccgg
4353661 cctgcccccc aacactcccg acgtgcgcgc cggggtcacc gctatcgcac agacaccgaa
4353721 cgaaacgtcg ggaaggtagc aactggtcca tccatccagg cgcggctgcg ggcagaggaa
4353781 gcatccggcg cgcagctcgc ccccggaacg gagccctcgc cagcgccgtt gggccaaccg
4353841 agatcgtatc tggctccgcc cacccgcccc gcgccgacag aacctccccc cagcccctcg
4353901 ccgcagcgca actccggtcg gcgtgccgag cgacgcgtcc accccgattt agccgcccaa
4353961 catgccgcgg cgcaacctga ttcaattacg gccgcaacca ctggcggtcg tcgccgcaag
4354021 cgtgcagcgc cggatctcga cgcgacacag aaatccttaa ggccggcggc caaggggccg
4354081 aaggtgaaga aggtgaagcc ccagaaaccg aaggccacga agccgcccaa agtggtgtcg
4354141 cagcgcggct ggcgacattg ggtgcatgcg ttgacgcgaa tcaacctggg cctgtcaccc
4354201 gacgagaagt acgagctgga cctgcacgct cgagtccgcc gcaatccccg cgggtcgtat
4354261 cagatcgccg tcgtcggtct caaaggtggg gctggcaaaa ccacgctgac agcagcgttg
4354321 gggtcgacgt tggctcaggt gcgggccgac cggatcctgg ctctagacgc ggatccaggc
4354381 gccggaaacc tcgccgatcg ggtagggcga caatcgggcg cgaccatcgc tgatgtgctt
4354441 gcagaaaaag agctgtcgca ctacaacgac atccgcgcac acactagcgt caatgcggtc
4354501 aatctggaag tgctgccggc accggaatac agctcggcgc agcgcgcgct cagcgacgcc
4354561 gactggcatt tcatcgccga tcctgcgtcg aggttttaca acctcgtctt ggctgattgt
4354621 ggggccggct tcttcgaccc gctgacccgc ggcgtgctgt ccacggtgtc cggtgtcgtg
4354681 gtcgtggcaa gtgtctcaat cgacggcgca caacaggcgt cggtcgcgtt ggactggttg
4354741 cgcaacaacg gttaccaaga tttggcgagc cgcgcatgcg tggtcatcaa tcacatcatg
4354801 ccgggagaac ccaatgtcgc agttaaagac ctggtgcggc atttcgaaca gcaagttcaa
4354861 cccggccggg tcgtggtcat gccgtgggac aggcacattg cggccggaac cgagatttca
4354921 ctcgacttgc tcgaccctat ctacaagcgc aaggtcctcg aattggccgc agcgctatcc
4354981 gacgatttcg agagggctgg acgtcgttga gcgcacctgc tgttgctgct ggtcctaccg
4355041 ccgcgggggc aaccgctgcg cggcctgcca ccacccgggt gacgatcctg accggcagac
4355101 ggatgaccga tttggtactg ccagcggcgg tgccgatgga aacttatatt gacgacaccg
4355161 tcgcggtgct ttccgaggtg ttggaagaca cgccggctga tgtactcggc ggcttcgact
4355221 ttaccgcgca aggcgtgtgg gcgttcgctc gtcccggatc gccgccgctg aagctcgacc
4355281 agtcactcga tgacgccggg gtggtcgacg ggtcactgct gactctggtg tcagtcagtc
4355341 gcaccgagcg ctaccgaccg ttggtcgagg atgtcatcga cgcgatcgcc gtgcttgacg
4355401 agtcacctga gttcgaccgc acggcattga atcgctttgt gggggcggcg atcccgcttt
4355461 tgaccgcgcc cgtcatcggg atggcgatgc gggcgtggtg ggaaactggg cgtagcttgt
4355521 ggtggccgtt ggcgattggc atcctgggga tcgctgtgct ggtaggcagc ttcgtcgcga
4355581 acaggttcta ccagagcggc cacctggccg agtgcctact ggtcacgacg tatctgctga
4355641 tcgcaaccgc cgcagcgctg gccgtgccgt tgccgcgcgg ggtcaactcg ttgggggcgc
4355701 cacaagttgc cggcgccgct acggccgtgc tgtttttgac cttgatgacg cggggcggcc
4355761 ctcggaagcg tcatgagttg gcgtcgtttg ccgtgatcac cgctatcgcg gtcatcgcgg
4355821 ccgccgctgc cttcggctat ggataccagg actgggtccc cgcggggggg atcgcattcg
4355881 ggctgttcat tgtgacgaat gcggccaagc tgaccgtcgc ggtcgcgcgg atcgcgctgc
4355941 cgccgattcc ggtacccggc gaaaccgtgg acaacgagga gttgctcgat cccgtcgcga
4356001 ccccggaggc taccagcgaa gaaaccccga cctggcaggc catcatcgcg tcggtgcccg
4356061 cgtccgcggt ccggctcacc gagcgcagca aactggccaa gcaacttctg atcggatacg
4356121 tcacgtcggg caccctgatt ctggctgccg gtgccatcgc ggtcgtggtg cgcgggcact
4356181 tctttgtaca cagcctggtg gtcgcgggtt tgatcacgac cgtctgcgga tttcgctcgc
4356241 ggctttacgc cgagcgctgg tgtgcgtggg cgttgctggc ggcgacggtc gcgattccga
4356301 cgggtctgac ggccaaactc atcatctggt acccgcacta tgcctggctg ttgttgagcg
4356361 tctacctcac ggtagccctg gttgcgctcg tggtggtcgg gtcgatggct cacgtccggc
4356421 gcgtttcacc ggtcgtaaaa cgaactctgg aattgatcga cggcgccatg atcgctgcca
4356481 tcattcccat gctgctgtgg atcaccgggg tgtacgacac ggtccgcaat atccggttct
4356541 gagccggatc ggctgattgg cggttcctga cagaacatcg aggacacggc gcaggtttgc
4356601 ataccttcgg cgcccgacaa attgctgcga ttgagcgtgt ggcgcgtccg gtaaaatttg
4356661 ctcgatgggg aacacgtata ggagatccgg caatggctga accgttggcc gtcgatccca
4356721 ccggcttgag cgcagcggcc gcgaaattgg ccggcctcgt ttttccgcag cctccggcgc
4356781 cgatcgcggt cagcggaacg gattcggtgg tagcagcaat caacgagacc atgccaagca
4356841 tcgaatcgct ggtcagtgac gggctgcccg gcgtgaaagc cgccctgact cgaacagcat
4356901 ccaacatgaa cgcggcggcg gacgtctatg cgaagaccga tcagtcactg ggaaccagtt
4356961 tgagccagta tgcattcggc tcgtcgggcg aaggcctggc tggcgtcgcc tcggtcggtg
4357021 gtcagccaag tcaggctacc cagctgctga gcacacccgt gtcacaggtc acgacccagc
4357081 tcggcgagac ggccgctgag ctggcacccc gtgttgttgc gacggtgccg caactcgttc
4357141 agctggctcc gcacgccgtt cagatgtcgc aaaacgcatc ccccatcgct cagacgatca
4357201 gtcaaaccgc ccaacaggcc gcccagagcg cgcagggcgg cagcggccca atgcccgcac
4357261 agcttgccag cgctgaaaaa ccggccaccg agcaagcgga gccggtccac gaagtgacaa
4357321 acgacgatca gggcgaccag ggcgacgtgc agccggccga ggtcgttgcc gcggcacgtg
4357381 acgaaggcgc cggcgcatca ccgggccagc agcccggcgg gggcgttccc gcgcaagcca
4357441 tggataccgg agccggtgcc cgcccagcgg cgagtccgct ggcggccccc gtcgatccgt
4357501 cgactccggc accctcaaca accacaacgt tgtagaccgg gcctgccagc ggctccgtct
4357561 cgcacgcagc gcctgttgct gtcctggcct cgtcagcatg cggcggccag ggcccggtcg
4357621 agcaacccgg tgacgtattg ccagtacagc cagtccgcga cggccacacg ctggacggcc
4357681 gcgtcagtcg cagtgtgcgc ttggtgcagg gcaatctcct gtgagtgggc agcgtaggcc
4357741 cggaacgccc gcagatgagc ggcctcgcgg ccggtagcgg tgctggtcat gggcttcatc
4357801 agctcgaacc acagcatgtg ccgctcatcg cccggtggat tgacatccac cggcgccggc
4357861 ggcaacaagt cgagcaaacg ctgatcggta gtgtcggcca gctgagccgc cgccgagggg
4357921 tcgacgacct ccagccgcga ccggcccgtc attttgccgc tctccggaat gtcatctggc
4357981 tccagcacaa tcttggccac accgggatcc gaactggcca actgctccgc ggtaccgatc
4358041 accgcccgca gcgtcatgtc gtggaaagcc gcccaggctt gcacggccaa aaccgggtag
4358101 gtggcacagc gtgcaatttc gtcaaccggg attgcgtgat ccgcgctggc caagtacacc
4358161 ttattcggca attccatccc gtcgggtatg taggccagcc catagctgtt ggccacgacg
4358221 atggaaccgt cggtggtcac cgcggtgatc cagaagaacc cgtagtcgcc cgcgttgttg
4358281 tcggacgcgt tgagcgccgc cgcgatgcgt cgcgccaacc gcagcgcatc accgcggcca
4358341 cgctggcggg cgctggcagc tgcagtggcg gcgtcgcgtg ccgcccgagc cgccgacacc
4358401 gggatcatcg acaccggcgt accgtcatct gcagactcgc tgcgatcggg tttgtcgatg
4358461 tgatcggtcg acggcgggcg ggcaggaggt gccgtccgcg ccgaggccgc ccgcgtgctc
4358521 ggtgccgccg ccttgtccga ggtagccacc ggcgcccgcc cagtggcagc atgcgacccc
4358581 gcgcccgagg ccgcggccgt acccacgctc gaacgcgcgc ccgctcccac ggcggtaccg
4358641 ctcggcgcgg cggccgccgc ccgtgcgccc gggacaccgg acgccgcagc cggcgtcacc
4358701 gacgcggcgg attcgtccgc atgggcaggc cccgactgcg tccccccgcc cgcatgctgg
4358761 cccggcacac caggttgctc cgccaacgcc gcgggtttga cgtgcggcgc cggctcgccc
4358821 cctggggtgc ccggtgttgc tggaccagac ggaccgggag tggccggtgt aaccggctgg
4358881 ggcccaggcg atggcgccgg tgccggagcc ggctgcgggt gtggagcggg agctggggta
4358941 acgggcgtgg ccggggttgc cggtgtggcc ggggcgaccg ggggggtgac cggcgtgatc
4359001 ggggttggct cgcctggtgt gcccggtttg accggggtca ccggggtgac cggcttgccc
4359061 ggggtcaccg gcgtgacggg agtgccgggc gttggtgtga tcggagttac cggcgctccc
4359121 gggatgggtg tgattggggt tcccggggtg atcggggttc ccggggtgat cggggttccc
4359181 ggtgtgcccg gtgtgcccgg ggatggcacg accagggtag gcacgtctgg gggtggcggc
4359241 gacttctgct gaagcaaatc ctcgagtgcg ttcttcggag gtttccaatt cttggattcc
4359301 agcacccgct cagcggtctc ggcgaccaga ctgacattgg ccccatgcgt cgccgtgacc
4359361 aatgaattga tggcggtatg gcgctcatca gcatccaggc tagggtcatt ctccaggata
4359421 tcgatctccc gttgagcgcc atccacatta ttgccgatat cggatttagc ttgctcaatc
4359481 aacccggcaa tatgcctgtg ccaggtaatc accgtggcga gataatcctg cagcgtcatc
4359541 aattgattga tgtttgcacc cagggcgccg ttggcagcat tggcggcgcc gccggaccat
4359601 aggccgcctt cgaagacgtg gcctttctgc tggcggcagg tgtccaatac atcggtgacc
4359661 ctttgcaaaa cctggctata ttcctgggcc cggtcataga aagtgtcttc atcggcttcc
4359721 acccagccgc ccggatccag catctgtctg gcatagctgc ccgtcggcct ggtaatactc
4359781 atcccctact gccctcccca aaccgccaga tcgcctcgcg gatcaccgtc cggttggcct
4359841 ccggcatttc acgccggctc ggccgctgga tccaccccgc gccggtattc gcagtaaccc
4359901 gttgaatccg cgcgcatgat gcaccgcttg ggcgatcagc cgggtggtca cctcgcttgc
4359961 gctggccgcg ctgtcgcacg gggcgctcgg tggtaacgga cgtcataatt aaccagcgta
4360021 accgaaccta agaccagcta gctgcggcaa tattggcgac caggactatg gcgccctccg
4360081 aacccggccg atccatgtca aaacattgac aatgcgtact cacgccgtgt cgggcgcgct
4360141 gaatgaccgc attgcggcgc tcattcggtg cgtagtcgct accaccgcaa caatgggctt
4360201 aggccattcc ttcgttcatc gcgcgggaca tggccgataa cgcagcggtc agctgctcgc
4360261 ccgccgcgtc gttatacgcg gacgccgcgg cctgcgcatt gtgcagcgcc tcgttgaccc
4360321 gctgagccac cgcctcggca cccagcttct tcagcaaacc atcttcgatg cgcaggccgg
4360381 tgagccactg gtgcccattg atcgtcactt cgacggtctc ggcttcgtcg gtggcgcgga
4360441 aggatccgtt gttcatctga ttgagcgtcc cgtctagggc cgactgaaac cgcgccgcca
4360501 gcgtcaacgc ccgggcgaca tgcgggtcca attcgtccat gctcacttcg actccttact
4360561 gtcctggcgc cgacggttac caatgacggc ctcggtccat gcccgatcct cggtgtagag
4360621 cgcctcgtct tcctgctgag aacccttgga cttggcgccc ccttgtccct gatgcgcggc
4360681 acccatcggc attcccatgc caccgccgcc cagcgcggcg ccgccgccgg cccttccctg
4360741 gcctaagccg gcaatgtcac cagcgccagc gggccgcacc gattcggcgc ccccgatcgc
4360801 ggatcccaac ggcgccgacg gcaccccgcc gcctccaccg ccaccgagcg atgccgcttt
4360861 gaccgccacg tcgcccgaca gcgctgcggc ttcccgccca gccgacgtca gctgcgccgc
4360921 cgtgtcagcc gggaggccac cacccggcga tccggtaggc ggaaccatcg gtgcggctgg
4360981 catcccggta ccgggagtca caccggagcc gtcagacggc ggcatcagga agccagggat
4361041 caatccctgc tcttgcggag gcgggggcgg gtcgatcttg atggcggggg gaggcttcgg
4361101 cgggtttacc ggttccaggg ctgccttgtt gttgtattcg gtcagcacct tctccgacct
4361161 ctgctgatac tccgcgtaca ccgggagaat ttggtcgcgg gccgaagggt tttccgcgta
4361221 aagccgttcg agcccgacta tgtcttcata agtcggatgt tcccgcctag cccacacgtg
4361281 cagctgcgcg acatattgag cctgcttggc catcgcagcg ctcaatttgg ccatgtggag
4361341 tatccattgc cgttgttgat cgagcgaagc ctcgcaagcg gtagccgcat cgccttccca
4361401 gttgtcaaac ccccggaacc gcttgacgtc gccttgcagc gtcaggttga aagtgttcca
4361461 cccatccgca aagtgcgcga gcgatgcgcc ttggtcgccc gtttcgagct tccttgccgc
4361521 ttctttgaga tccatgaagt tgggttcacc ggccgtggcc accctcggcg tatcggttag
4361581 ttcggccgaa ctgtcccctc cgacggcccc ggccgattct gcctgcacag ttccttcgcc
4361641 gtcgttgtcc agcgcggtcg cagcctcctc atcaacctcg ccatacgcct tggccgcgtt
4361701 gcgcagcgag gtcgccagac gctgccgctc tttggcaccg gccgccaggt attcccgcat
4361761 gttgtcggcg gacaatacca gctgttgggc ggcgttttta gccgccgtga gttcgcacgg
4361821 tgtgatgggg acatcagtcg gtgggtccgc catcggggcc tccacctcgt tggccctgtt
4361881 caaaatctct tgctgatcca ccgtcacggt ctgcgactgc gtcatatcgg atcatcctcc
4361941 ttagtgctat agccattatc gtcgctaaac tgaaaggttc ctgcactaat ttgatgccgc
4362001 ccgttcatgc cggcatcgcg aacggatcgc cctacttcgg cagcgccatc tggtagcggc
4362061 tttcctcggg tggggaaacc cggcgaatcg gcagctgccg atgccgcggg gtaccgatca
4362121 cattgtgccg cagaatcacc cggtcaatac cgggatgcgg gccgagatag gtcgtcgcat
4362181 tcggccacgc cacctttacc tcctgcccga tgtgtgcgcc gatcaaccgg gcaaattcct
4362241 cgaactgtgg cccgactgtg accatcgcac ctgccgccgc cgcacgcacc acgaactggg
4362301 tgaatgtctg agcgtcaccc aggttgaggg cgatgtcgac atcgtcgaag ggcatgtaga
4362361 ccgggcatcg gttcaccgtc tcgccgacca gtaccccagc tgacccgatc ggcagctggc
4362421 agtggcggtt ggccaccaga tgctggcctt gcagcgcggg ccgctgcccg ccaaataggc
4362481 gggcgaagcc cctgggtgtc ttgggcttgt ccgccgtggt cagcaacacc gtggactgcg
4362541 gggccatccc cggcgcgacc cggactctgg tgatggtgtg gtccgcgcgc gccgaccacc
4362601 atacatccgg acctccgggc gccgcgtagg cggcagtgta ggcatcgcgc cccttgatca
4362661 tcgaccattt ctcccgcaca aagccgatgt cggtggcgtg gtcgtagtca tcgaagctgc
4362721 ggccacacac cgcgtcgaca ccatggctag ccagtcgatc ggcaatgcgc gtcgcggacg
4362781 ccaccaaata ccgggccagt cctgcgacgc cttcatcgcg gcgctgcgcc gatttgcggg
4362841 tgcgttccgg gtcggcgcgc agcacgatcc aggtccggcg gttcgccggc gccgggtctg
4362901 tcccgatcac ctgctgatac agactcacca cgtccggcgc tgcggtattg ccgacgcggt
4362961 agccggctga gacgatatcg gcctccaagt cgggacagtg caccgacagg agctcctcca
4363021 ccagtccggt gtccagcatg tcgtcggtgt gggcttgccc gtcgacgatg accgtcggcg
4363081 tgaatggtcg gggaatgagc tcgattacgg cgaccagaaa ctcgccttgc cagcgcaccg
4363141 caacgtgatc tcctggcttc acggtggccc cgaccacagg ttctgacgag gaatccgggg
4363201 gccgtcggcg ccgccgcaac cacgcgtaca ccgccgccac ccagccggtg atccggcggc
4363261 cgtagaaagt gaccgtggcc acgatgacgc ccaacgaggc cagcgcaatc cccgcccacc
4363321 agtagcgcgt ctccaagaat gcgatgatgc atggcggggc caacgcggag gcaagcaagg
4363381 cgtgcccggt gctgaaccgc agccctaaag gatttctcat cggcggctca gcgcccgtct
4363441 agccagcgcg cccaggccca gggccaacgt aaggccgacg gccaccaacg ccacagccgt
4363501 aatcgggcga cgatcgggac ccggctccac caccgggggt ggaagtcgtc tgacgttgta
4363561 tggcgccgaa gcagggccgg gcggaatgtc ccacgtcagc gcggccaccg catcgatgac
4363621 gccggcgccg accaggtcgt cgaccccgcc cccggggtgt ctcgcggtgg cggtgatccg
4363681 gtggatgatc tgcgccggcg tcaggtcggg gaaccgctgc cgaagcaggg ccgccagacc
4363741 cgacacatat gccgcggcaa acgaggtgcc ggcgatgggt accggcccct cccggccttg
4363801 cagcgcattc accggttcac cggtgtcgcc gagcgcgacg atgttttctg cgggcgcggc
4363861 cacgtccacc cacggtccgt gcatcgagaa cgagctgggc atcccggtct ggccgatacc
4363921 gccgacgctt aacaccagcg gtgcgtacca cgccggggtg acaacggtct gcacattgtt
4363981 ccagccgcgt gggtcgccgg gtgtggacgg gtccggcgcc ggattctgta cgcaatcgcc
4364041 accggtgttg ccggccgcga ccaccaccac cacgcctttg acgttgaccg catagtcgat
4364101 ggatgcaccc agtgaggttt catcgatcgg cctgctcacc ttgtagcagg cggcttcact
4364161 gatgttgatc acacccacgc cgaggttggc ggcgtgcacc acggcgcggg caagactgcg
4364221 gatggaaccg gcggccgggg tggcgttggg gtcattcggg ttggcttgtg agccgaccgg
4364281 ttcgaaggcc tcagacgtct gacgtagcga gagcagtcga gcgtcgggcg cgacgccgac
4364341 gaacccgtcg gtgggcgcgg gccggcccgc gatgatggat gctgtgagag tcccatgggc
4364401 atcacagtca gacaggccgt taccggcctg gtcgacgaaa tcgccgccag gttccgccgg
4364461 gacccgtggc gaagcgtcga caccggtgtc gatcaccgcc accgtcaccc cggccccggt
4364521 cgcgaacttg tgggcatcgg ccacgcccag atacgtgttg ctccacggcg gatcgtggaa
4364581 cccggacccc ggcagcgtgg tgggcgacgc gcacaaaacg cgctgttcgg taggctgatc
4364641 cgggcccgtc acgtcgggcg gcaacgcgcc cggatcgatc ggcggtggcg tgatggccga
4364701 tgcgggcgac gcggtgagca acgccagcgc caccgtgatc agaaagatac ggtgcactcc
4364761 cagaacactc cattcgttga gattcattgc gattcattga gctgcgttgc taccttgggc
4364821 cacttgacgg acctgtgtgc attttagacg taacggctgg gcaaacaacg ctgtcacgcc
4364881 tgggctggtc cgccgcgccg accagggcgc gtaggcgctg tacctggacc acgccgggac
4364941 tcaacggttt tgctaccgca ctagccgata tgcggctgct accaaacgat cgcggccatg
4365001 tctcggttgt ctgagcacac gctgcgtatc gcggcatcga tgtcggtggc ggtgatgatc
4365061 tgcagatcct gaaccgatac cggttggccc gcacgttttt gcgcaaccac ccgggtgtcc
4365121 cggaaccctt cggcgcgttc gatcacgttg cgggcgaacc gaccgttttg catagcgtcg
4365181 ataccgtgct gcccactagg ggtggtgtag ttacggatgg tggtgaccgc gtcgaggaat
4365241 acctcccgtg cggcgtcatc gagctggctg gcgcgcggtg tagcgtagcg gtgtccaatc
4365301 tcgacgatct ccaccggcga ataagactcg aaccgcagct ttcggttgaa ccggccagcc
4365361 aaacccgggt tcacggtgag gaattcatcc acctgatcct catagccggc cccgatgaaa
4365421 cagaagtcga atcggtgtgt ttccaattga accaggagtt gattgaccgc ctccatgccg
4365481 atcatgtccg gtgttccgtc ttgatgacgt tcgatcagcg agtagaactc gtccatgaaa
4365541 atgattcgcc cgagtgactt ttcgatcagc tcgttcgtct tgggtcctga ctccccgatg
4365601 tagtgcccac agaagtccga tcggcgaact tctcgaattt cggggtgacg cacgatcccc
4365661 atgccggcgt agatcttgcc gagcgcttca gcggtggttg tcttacctgt gcctggtggc
4365721 cccaccagca acatgtggtt ggtctgcccc tccaccggta ggccgtgctc taggcgcatc
4365781 atgcgcacct cgagttggtc ttccagcgcc gataccgctt gcttgaccgc cgccaggccc
4365841 acctgtttgg ccagcagttc ccggccctcg gctagcagct cgccgcgccg ctgcgctgca
4365901 ttgtcgtcat cgagctggtc gcggcttttc gccgtcgaag catcccaacg gtcggagcgg
4365961 ctggcgatgg ttcgttcatc ggtaacaatc aagcgcaggt tcgggtccgc cagggcttct
4366021 ttggcggcgt cggtgagcac cccgttgatg gtggccttcg acagccagat ctgggccttg
4366081 tcctcctcat gcagttgccg gtacaccatc ccccgcacat acgccaagtc ggcgaccagc
4366141 agcggaatat cggccggtcc gatcgccgcg gtgagcacgt cggcgccgaa ccgctccgat
4366201 gacctgctgt gtccgatcac gtccacccgg tccagccagt ccagggccac tcgcccctgc
4366261 ccgagatggg cggcggcgtg ggctgccagc gcacaaatcg acgcggtcac cgccggcatg
4366321 acgatcgcct gtggcggcag atcctcggcg gccgtcgaca acacgtcggg ccatcgctgc
4366381 gtgacgtaca tcaggaacgc ccgagccagc tgatgccact ggtagttgcg ccacgaatcc
4366441 aatagctcgc ggtttgctaa cagggcatcg gccttcgcat actcccccgc gatcgtcaac
4366501 gccgacgaca gcgccagccc cacctgagat gcgtcggtca ccgtgatccc gatggatggt
4366561 cccagctgga cctcagcggc caacgtccgg ccgatccgcg tggtctcgcg gtgcagccac
4366621 tcgctatggg cgttgagctg cttaagcgag gccagatcgc ggtcaccgca ggcgatacga
4366681 cccagccacg cgtcggccat cgacggatcg gcctcggtgg cagccacaaa ctcaggcaac
4366741 gccgccacgc atccctggcc attcttgatc gtcatcgccc gatcgaaatg ccggcgcgca
4366801 gtgagtaaat cacccatcgt gtccaccatt ctcgacatcg ccgccgctgt caccgcggtt
4366861 gcaacgtgtg tctgtcactc tgtgcctcaa attccgttgg caacgttcta ccggcctatc
4366921 gacatcgtga ccggctcaag gctgacatag cggttctccg cacggaacat ttccatctca
4366981 accagccagt tttgtcctgc cgcaccgact ttcaccgttg cccgatcgat ttgttcgatg
4367041 gtcacctcga agccatgccg atcgctctcg gacagcgagg taccgggtcg ggcaatggtg
4367101 atgacactgg ctggccgtgg cgtgggcgaa atcgcgacat cgacaccgct gccttcagat
4367161 ttgccgtcat cgccgttctt gcgccgccgc acgtactcca cgacgccgac agtggtgcgc
4367221 ggcgcgggcc gtggtgtgcc gacgatgctc aactgcggca tgcgtacgct ggcccaacgc
4367281 tcttggtcgc gagtgtgcac acacacccgc tcaccggcac cgacgacgcg aatcacgatc
4367341 ctcttggcga tcgtgtcgtc cgcggccacg aagacgcgcg acagctcacc ggcgtcggta
4367401 acgggaatca tcagccggtc cccgttgctc agcttgccaa tcaacacccc cgacggtccg
4367461 atctcggtga ctagctgcgc cggcaacggg cagcgccgct gtccgcgtag gtgtggacgt
4367521 ggcccgcaca tgttggccgc agccgcggcg gcttgctcac cattgagccg acgcaagatc
4367581 acactgggcg gggtaggcgc cggcgtcggt gtgcgcacgg tgatggtcgc ggtgcacgtc
4367641 gcgtccggat acaccgttac gttctggatg acctcatcgg cacgcagcgt ccaggcttgc
4367701 gagagaaccc gcgacgaaat cgcctcagcc gggtacgcat acgtcgtcat ccacccggct
4367761 tcaccgcgga tagctttcca gcgctgcgca ctcccggcta ccgcgtccga ccccagccgg
4367821 cgatcaagct cagccaagtc tgttgcggtg gccagtttgg cgcgcaagcc ctgacagcgc
4367881 agggagctgg caacgcgttg ggcgaccgaa atggcagcgg ccccaacgct ggtacgccag
4367941 cgtaaagctt gggtgttgcc gatcaccgga agccgcatga tcagccacgt ttcgcgccgc
4368001 ccggcatacg gcggcgtacc gatctccgcg tcatacaccc gcgggtaatc gccgacggtg
4368061 ccggttcgcg agccgaaggt gacgacgctg attgaatcga gttccaggtc cagcgggtgg
4368121 cgcagcaacg gcgcgagctc aacgacgtca atcacgttgt cgctttctac ggtcaccgac
4368181 ccggtgaccg tagtcgcccg gtgcgctcgg ccgagaagtt gcaccgccac caccgcgaca
4368241 ccgtcttgca cgcggacgcc acccccggat cggttgttgg ccaaggtaat tgggtcattc
4368301 catttgacgg gacgccgacc ccgcagcccc agtaccgccc acgaccacgc cggctgaccc
4368361 caccactgta cgaacaccaa ggcgacgccg accacgacag ccatgaccgc acctagctgg
4368421 ccgcccagcg cccagcccgc cgacgcgagc acgaacactg tccacacccc ggcgacccgc
4368481 ctcgcactgc gcgggctgaa cccggtcagc ttggacgtca acgcgccctc cgtagccgag
4368541 ccccgattgc cattgccagc acaccggtgg ccactgcgcc gacgaacccg atagcgatat
4368601 tgcgcgcccg gtgatcgggc ggagggggtg gcgcggcggg cgtgatcacc cggctctgtg
4368661 cacccggggc catccgatca ccggatggga tgttaaacgt caatgcggcg accggatcca
4368721 ccagcccgta ccccagtttg ttgtccacgc ccgcaggcgg attgtgcgcc gactgcacga
4368781 tccggttgat cacttggtag gcagtcaact cggggaattt ggcccgcacc agtgccgcga
4368841 cgccgctgac gtaggccgcc gaaaagctgg tgccccagaa cggcatattc ttctcgcctg
4368901 gccgcgacgg cgggtaggca ttgaccggtc cgccgccttg tggcgataga cccatgatgt
4368961 gggttcccgg tgccgcgaca ccgacccacg gacccgacat gctcttgtcc agtgcggcgc
4369021 cgtaggcatc gacggcacct accgacagga cgtaatcaga gaaccatgac ggtgacgaca
4369081 caaccgtgac ctgatgccag tcccggggat ctgacgggtc cagcgggtca tacatcgggt
4369141 tgttgccgca gccggcctcc ccgtcgttgc cggctgctgc cacgatcacc gcatccttga
4369201 cggtggccgc ataccacagc gcggcgccca gcacccgctg gtcgcccgga gccgccgcag
4369261 gcagacatgc ggtcaccgaa atgttgatca ctttcgcccc catgttcgcc gcgtgtacca
4369321 cggcacgcgc caccgagtcg agggtgcccg ctttgacttt ctcatcggag ttgggacccg
4369381 ccgacgacgg gttgaccggc tcgaaggccc gcgaggactg ccgaatcgag atgatggtcg
4369441 catgcggggc cacccccacc accccgtccg gggcgcccgg cgggggtggg ggcaccgcgg
4369501 gttcgtcttc ggtttgcgga tccggcggtc cattggacgg cgccatggcg cccgcatcct
4369561 cgggtggtgg tggcggtggc gcaacggttt gggtgatcgt caccggcggc ggcgggggca
4369621 tcgggggcgg gacttctacc ggcggcgccg gcgcggcggt gaccggcggc ggcccggccg
4369681 gcggtgggaa cgccgcggtg gccggcatgg cccttggcat cggtaaaatc ccaagcggtg
4369741 cagcggcaat gatcgaactc accaccgtgc cgtgcgcgtc gcaatccgat aggccgtcct
4369801 cccccatgat gtagtcgcca ccgggcacca ccggcagccg cgggttggga ctgacgccgg
4369861 tgtcgatgac tgccacgggc acaccgttgc cggtgctgta ctgccacgcc ttgctgatgt
4369921 tgaccaggtt gaagcccggt gctagctgcg ccacgtcggg atttcttacg gtgatcggtg
4369981 tggagcagct gttggagcgg cgcatgggct gatcaggtcc aggccgcgcg tctgcaggca
4370041 ccatcgccgg atctaccgac ggcggtggga tagcctgtgc cgcaggaaca ttagctgaca
4370101 aagcaacgag ggtgagggcg gcgctcgcgg ccgcggcccg caggccaggt cggtttagtg
4370161 gcgaagccat gcaaacagcc cccctagggc cgcagccgct ggtaacaacg cgatcatggc
4370221 cagcacttct agccattcca cggtcaaccg gatgatcggc ctaaaccgcg tcgccggtac
4370281 cacgagggcc acggccaaac ccaatgcggc gaaagccgcg acgaagatcg caggccaaag
4370341 cagcccggtc tgaacacctt tcggggtgtc gagggcgtac ttaagcaccc cggcacacac
4370401 cgcggcggac gccccgcaca ccaatgcgac cgcttggtat ttggcggcga acccgcggcc
4370461 ctgggtgatg aagaggccca ccgtcaagcc ggcaaccaac aacgccaacc aggcccacgg
4370521 ttgacgtggc gtcagcaccc cccataccgc ggcgggcagt acgagcgaca ccccgacgca
4370581 catacccacc tgtaccgcgt taaccagccg cgccgacgcg gcgatcgcgg tgccgcgggc
4370641 ggtgatgtcg gtcagttcat tgtcctcatc gtcggcgtcg gcttcgctga ccggagccac
4370701 cgtatcgacg ggcattcccg cacggcgcgc gaacagatcc cggccggtga tcgatccgaa
4370761 gtgcgggggt cgtacccgtg ccacccacaa cgcaacggtc ggagtcatcc tgatcaggac
4370821 aagcagccct accagcacgc aaatcgccag cacctgcatc gaaaccggcc taaacattcg
4370881 gacggcggcg acagcggcaa ggatcccgca caccgttacc accgcggtga ccactgcggt
4370941 ctgccaccgc ttgcgggtcg ccacgccgat cgtgatcgca cccagaacca ccaccacgag
4371001 cccgatcagc gcatgagccg ccccgagcgc gcccggcggc gcgcacgcgg cggccacggc
4371061 aagcaacacc accgccagcc acccgaaccc actgaacagg tcacggcgct cccgccaacc
4371121 ccaccacacc accaatgccc cgatcaccag gagcacacca atcccgccag ccatcgcagc
4371181 tgggaccggg ctgtcggtga ttgtgcgtgt ccgcaacgtc agggccagca ccactccgac
4371241 cgccatggcg ataatcgcca tggcggtgtg ggcggcagtc agcgaggtta ccggcgcaaa
4371301 catccgatcc ccgccgtcac gccccagcca cttgcccatg gccgccagcc cggtggatag
4371361 cgattcgtac tgtggctcaa acgactcgcc agcaacccgg ggtactagca ccagcgtgtc
4371421 accgtcttga acgcccagct cgtcgaggct cttgttgatg tccagccgca ccccgttgat
4371481 cttgtgtagc tcatagctac ccgccggcag cgcaaccccg tcgaaacctt tgcgcttcag
4371541 atcggcatcg aacaactcca ccattccttc gaagaatccc tctactggaa ttccggcggg
4371601 gaatacctgg gagcatagat gcttgtcgta gcaaatgttg accgcacaac gtgccgggaa
4371661 agcaacctta tgcggcgcag tcactgcgcc gcccgttcgg catccggaac gtatttgtcg
4371721 gccaatccgg cggtgatttc gaaaagccgc aaccgcgact tcttatttaa ttcatgcacc
4371781 gtatcaatga tcccgccttt ggccaggtgc ggatcgaacg gcattgcttc cacgattgca
4371841 ccgaccttgg taaaacgttc ggtcaggtag gccagcgcat ccttgtcggt aatgctgtcg
4371901 gtgtggttga ggatcacggt gctgcgcgag accagctcgt gataaccctg cgccctgagg
4371961 tagtccaccg cccgcagcac cggccgggac cggtccgcgg tgattcccga gacgaacacc
4372021 agggtgtcgg tgctctgcag cactgccttc atcacgtcgt gctctaggtc gggcgaggtg
4372081 tcgatgacaa tgacggtatg agttcgccgc agccgagaca acactgcgga gaacatcgcc
4372141 gggacgagcg gcctgggctg gtctgatgtc cgatttccgg ccagtacgtc gagcccgacc
4372201 gtgttttgcc ccaggtgttc gcgaatgtct gcgtagccct ggacatcggt gtcgttgata
4372261 atggcggcgt aatcccccgg cggcgactcg tcgatgcggt cggccagggt accgaaactc
4372321 ggaaccgcgt cgatcgcaat cacgttctcc gggcggcatt cccgaaacac gccgccgatg
4372381 cacgcggcca tcgtggtgac ccccacgccg cccttgccgg acacaaccgt gatgacatat
4372441 tgccgacgga tatgccgacg gatacgtccc tgtaaattgc ggtagtgccg ttcccggggc
4372501 gattcacctg gattaatttt gtgaaatgaa acggaataga cgaatttccg ccaaccggtt
4372561 cccgggggaa tctttctagg ggcagccaga tcggtaatac gcatggtgtc ggataccgaa
4372621 tcccgaaagt gatgccgcac cgacggatcg ccgcgtccga tcgcgccgtc gtctaacata
4372681 ttcgggtcat tccacgggtt cgtcacgacc gcgatgctaa catgattcga gattccttgt
4372741 ttactgcgcg tgagcggctc tttgagtgca ttagtttgct attcgccaga caatgtcatt
4372801 cacaccacac gccggtatga gtaccattcg tcaccagcgg gcaagcggcg gatgagccgt
4372861 tgcaccgccc caccgatatc agagcgcgat ccaggcgaga ggacctggta acgtcgctgt
4372921 cccgaggtca cgctttcgac gcagatgcgc ccggcggcag tgtccacgat ggccaccgtt
4372981 gaatcgccga ccaggatgcg cgccgacttt tccggcccga cgcctgcctg cagcgccacc
4373041 agggtggcgt gcgcggagcg tgtgggatcg gcggccatgg ttaccatctg tagctggtcg
4373101 acgtccaggc gctgactgag cagatacgac cgcaaggtgc cggcgtcgcg tacggcgtgt
4373161 agtagttcgt cggcgtcgac ggtgaccggc cgtagcgggg cggcctcagc gacaccgcac
4373221 aaccgctcga cctgacccac cacgagttcg ccggccccgg cctcgtcact ggcggtgccg
4373281 gccgggtaga gccgcaccag gttgccgtgg cgttccaaga ccacccacca ggtggcaaat
4373341 cggcaaatgg ccgcgcgcgt cggttcgccg cccggcaccc cgatcgttac cagtaacccc
4373401 aggtcgcgtc gcaacagcac ggtcagccat tcacggacca tggggtcggc attaccggcc
4373461 tggtccagag cccccaccgc catcaactcg gcggccaccg ggtggcgaag tgcccgctcg
4373521 gcggtgtcca accgcggcaa caatggccgt aatcccagtt ccggacaggt ttgttccacc
4373581 ccggttaccg cttgtagtac ccacaggcca tcgaccgtcg tcgtcagcat gtcacgttca
4373641 tctcaaccag ctagcagcaa gcagaaggtg gggcagacgc gcggtccgcg catgtacccc
4373701 accttcactc ggcccacggc cggctttaga acaagcccgc gatggcctgg tcggttccga
4373761 tcgcgttgtc cagcacgtgg ccggtggtag tcccatgctg acccaccgtc tcaatgagcc
4373821 cctgcagccc cgacagcatc tgcgcctggg cgtcgaaaaa cccttgcgcg ccgtggcccg
4373881 cgaaaaactc ttgcagcgca tttgttttgc tggcggtgtc ttcgtaaatc atgtggagct
4373941 ggccggcgcg cgagcccacg tcggaagcga agtcggatac ggctcccggg ttatacgtga
4374001 tttgatctga catgtgaaat tcctttccga ggcgtgaaac gagttgggtc aggatccgtg
4374061 gctagcgccg aacagcgcct gaaacgctgt ctgcgagtcc gcctcgtgtc cctccatcag
4374121 ggctgcggcc tgcacgaggc cctcggccag gcgcgtgccc ccggtaagga ccttgttcaa
4374181 ttcattggtg atctcggtgg ctgtcatatg cgaagcaacg acgccggtac cagaccaggt
4374241 ggcggggttc atgacgtttt cctggttggc taggtagccc ttggcgattc ccatggcttg
4374301 ctccatattc gcctggatat cgttggcggt gctgcgcagc atctgcggtg ttacctgaat
4374361 tgtgtctgcc acgggccctt ctcctttact gccgttagcc gttccccctc aaatatcggg
4374421 gcatgacgcg aagtgtatgg ctgctctgcg gacctgtcga ttcaccctgt gcccgagcta
4374481 gatctaccgc cggtcatcga caacacgcac cgtcgcggcc tgctcggact tgccatggga
4374541 tccgcggtga ccccccgccg catgtccgac cggcatgcct ccgatagggg tgccacccac
4374601 cgtggtcgtc ggcgcgcgca cgacgtcggc gcccaaagcc ccgctgggcc gcaacccgac
4374661 cggcctgccg ctggtgcccg attcgaaagc gctgacggga cgtgtgaagc tcgtcgctgg
4374721 cataccgccg ccgcccaggg cggcgcctcc gccgcccgca ccgacctcgg tggccgcggc
4374781 cgatatccca ccggccgccg aagccgccga ggctcccggc gccgccccgc ccatgcccag
4374841 tgcgcccggg ttggcgaaca tgcccaccat cgattgcagc ggctgcatcg cgctcatcgg
4374901 tgcctgcatc agtcccgacg gcgcctgcag cgcctgcggg gccgcttgca tcaccgcctg
4374961 catcggctgc atgaacgtgc tgagctgatt gccgaagttc tcacccgccg acgttgactg
4375021 acccgcgccg gttgaccctg cctgcacgcc ctggtaggcg gaacgcatcc cgtcaccggc
4375081 cgcggcctcg gcggccgcct ggccaaccgc cgccgcagcc tgtgccggag cggccggaga
4375141 tgcacccatg gtcgcgaccg gcggcggaat tgccagactc tcggccagcg cggcgagaac
4375201 ccctccgtag gtggcgccca ccgcggcgtt attcggccac atcaccccga aatactcgac
4375261 gtccaaagag acgattcgag gcgttagtgt ccacagcacg ctggggttga tggcgttgtc
4375321 gacgccccat tcgtcgcggt tctccatgca ctcgggggca gggcgcatgg ccgcgttggc
4375381 ggtctcaaac gccgcgatcg cggtcgatac cacggccggc ttcacgtcga cccagccggc
4375441 cagtccgtgc agcgtggcgt tgagcatggt gacgttaagc gccgaggccg ccgacccgac
4375501 acccaaccag ctcgccgcgg tggcggcggt gttgatcgcc gacgcgacac ccgaggcgtg
4375561 gtggctggcg cccagtgtgg tccacgccgt ttgattggcc agatgggtgc ccacgccggt
4375621 gcccgccgtg agcagcaggt cgttggcctc aggtgtccgc gcagcccatc ctggatcggg
4375681 catgcctact tacccttgca gcgccgatgc cgccgcgcgc gccgcttctg tggtcacgta
4375741 cacgcccgac gcgaggccct gctaacccgc gaacaggccg cgctgactgg cgtgttcggc
4375801 aacgacaccc aggtagctgg caccgcacgc gttgagcgct gcggagaaca tcgcggagtc
4375861 gggatcacca cccatcggcg tggtgctaag cagggctggc gccgctccgg cggccgctgc
4375921 ctcggtttcc gcactgatcg ccgactcggc agctgccgac gccagcactg cttctggttg
4375981 cacagaccaa accatgttcg cccctccgat tgcttctgca atgcgtgatg gtcgctgagt
4376041 gtaatgcgag tcggccgatc gcgtatgcgc aaatcagtcg tctgcaccga tgccgacgtc
4376101 gaactggtcc acgccgcccc atgtgttcca gcatgtcagc ggtacgtgtg gggcggatgt
4376161 gaaatctgcg acgcctggag gatacgcgcg ggtgtcactg aacccgtaca gcgacatggt
4376221 caggcagaaa gtagccatgc gcgctatctt gcgatccggc cctactgctc gccgggcacc
4376281 gacggatacc ccaccaaaat cccctcgacg tcgccgtcgg caccgaccaa cagacctcgt
4376341 ccaggcggca acgtttgggc tcgcaccgat cgattgattc ggttttgcgg atcgttatcc
4376401 atatacaact gggccacttt cgccgaggtc tgggatttca cccaggggtc catcggcatc
4376461 gtggcccagt tcgcgctgtt gcgcgtgctg aatacgtgca aaccgacctg gcgggcgcgt
4376521 tccatcaact tccacagcgc cgcacccacc ggcggcttct gtgggtagct ctgagccggc
4376581 cgcaggtcct gcacgtcgtc gatgagcaca aagtgccgcg gtccttccca cggcttgagt
4376641 gcgcgcaact cctcctggct caaacccttg ggcggcaacc gcggcagcaa gatctgctgg
4376701 gccaactcgg tgatcacctc gtcgatttca tcttggtcgt aggcatacgc gcgcacatac
4376761 ccaggggcgt gcagatctcg cagaccgtgc ggagccgttt tagggtcgat cagcgtgagc
4376821 tgcgcctgct gcgggctgaa ccggttcatc accgcctcgc cgatggccac cagcgccgtg
4376881 gtcttgccgc agccttgccg acctaagatc atcaaccctg ggctctcgcg cagcttgatc
4376941 ggcaccggac ccagctcgtg gcgctctccg atcgcaaacg cgatcgacag atcgtcaccg
4377001 ccctggtgga cggcctcgtg ctcgacaatc gcggacagtt ccacccgctg tggcagccgc
4377061 tgcagacttg cgtgcttggt caccccggcc acgtcggcga ttcgcgcccc gacatcggtg
4377121 atgcccacca gctcgccggt accggggtcg gccagggccg gaacaccgat tcgcagctcg
4377181 tgcaggcttt ccgtcaaacc aaatcctggg cggttcaacg tccgccgcgc cgcctcccgc
4377241 gattcgatcg acaaatgccc catctggctc tcaccgggat cggccagccg caactgaatt
4377301 cgcgccgtga cattctgcag caggctctgc cgctgcccat gaatccagcc gccggcactg
4377361 cacatcaggt gcaccccgta ttcgggaccg cggctgctca acgagatgat gcggtccccc
4377421 aacagggtgt ccttggcgta caggtcgtcg tagtcgtcga gcaccacaaa gacatcgccg
4377481 aacgcgtcgg tgggatcggt gccacccacc ccgtcgccgc cgatcccgaa ccggcgctcg
4377541 cggaacccgt ccatgtcgat cttggctcgc cgaaacgcct cttcccgcgc atcgatcagc
4377601 gcatccatgg tgctcaagat gcgttcgatg ccctcggcat ccttgggcga cacgatatcg
4377661 gtaacgtgtg gaagcgaccc aatctgggcc atggtcgccc cgccgatgca aaagaacgtc
4377721 actcgctccg gggtgtacat cgttgccgcc gaacacatca gcgccatcaa ggttgtggtc
4377781 ttgccgcgct gcttggcgcc caccacgatg atgttgctgc gtagcgcgtc gacggcgtgt
4377841 accacttgct gggattcttc ggggatgtcc atcactccca ccgggaacat cagtcccggg
4377901 ttttgaccgt agtcgacatg ccagggtttg ccacgatacg cagccaccag cctatcgacc
4377961 ggctcggggt cttccagcgg cgccaaccac ggccggcgcg gcgatcggtg cggcacgttg
4378021 tatagcgact cccgcagcac gtcgacgatc ttcttcttct tgaaaccgtc gtcgtaatag
4378081 aggaattcgt cgggttccgc atcggcggcc gcggcggtcg ccaatgcctc ggcgtcggcg
4378141 gcatccagcg gttggtactg ccagtcgtac agccggggtt gggtcaacgt catgtcgatg
4378201 gttcgggcca cctctttctt cttcggcacc acaaacggcg cagagaggta aaagcagcgg
4378261 aacggttcca gatcccgcgg ccccaccttg agcagcgcga aaccgttctc cttcgacggc
4378321 agatggtagg cggcgtcgct gccgatcact tcgcggctgt catcaccgga ttcagcgcgc
4378381 agcgcaatcc gaaacgcgat gttggacttg accttttgca gcgacgacag gtccagccgt
4378441 tgaccgccta gcatgaagaa gacgttggcg ccgcgaccct cctgaccgat gtggatgatc
4378501 agatcaatcc actttttgtg gttggcgaac agctccaggt attcgtcgac gatcaccagc
4378561 agcaccggca ccggcggcag atcgcgtccg gcgaggcgaa tctcttcgta gtcgttggcg
4378621 tcgcgcgcac ctaccgattt gaacagttcg tagcgctgtt tgatctcgcc gtcgataact
4378681 ctgcgcatcc gctcggccag atgccgctcg tctttgccga ggttggatag cgcggccacc
4378741 acgtgcggga tgcccaggat gtcctgggca gccgattcga atttcatgtc gacgaagatg
4378801 acgttgaatg tttccggtga gtgcgtcagc gcgatcccat agaccaacga caagaagagc
4378861 tccgacttgc ccgagccgct ggttccgatg accactgagt gaaacccgaa gccgccaaag
4378921 tccttggcgc gcaggatgat gttctgcagc tcgccgttcg gtttggcgcc caccggaatc
4378981 tcacaccacc gatcgtcgcc gcgaccgcgc cgctcggccc acaaccgatc gacatccaat
4379041 tcccgggggt cgctaatgcc gagcgaacgc agcagctcgg ccgcgccgct ggtggaatcg
4379101 gtgacctcgc tgcgactggt cggtgaccac cgcgccatcg cccgcgcata tcggtaggcc
4379161 cggtggatgg acagctggtc ggcatgcgcg aagaacgtgc cgcgcgcccg caacagcggc
4379221 gccgggcgct ggtcgtcatc ggcgtctgcg ccatcgcgac cggccttgac cgcggttgcc
4379281 gccccatgtc gttgggccat ctcgaagacc tggtcctcgg cgaaccccac accggtgccc
4379341 acccgggacg cgatgcgcag caccgtaagc ccggccttgc cgacctgccc gaccacgctc
4379401 tcccacgcat ccgggctgcc ggtgttgtcg tcgacgatca ccaggtgcgg ccccaaatcc
4379461 acgccgacct gcccggtttc cagcgccgag cccatcgcgg ttgggctggc caccgtcggc
4379521 ggggtccatg cgcctcgctt gcccttcata tgcagctcgg ctcccagcgc cgcctccagt
4379581 tcctcgggtg tggcaaagat cagccgccgc cagccgcagg catcgaacag ctcgtcgtgc
4379641 aggttgtggg ggagccacac catccacgcc cacacctcgc ggttgcgcgt caccaccatc
4379701 agcttgacgt cacgcgggtt gtgaaacacc gccagcgagc acaacaccga ccgcatcagc
4379761 gaccgcaccc ggtccaggtc ctcgctcacg aagctgaagc ctggtgccga ccgtaggttc
4379821 accaccttgg cgatatcgcg aatcttgcgc tgctccaaga tgaaatcgcg cagcgcctgc
4379881 ccggtcacgg gctctagctc ctcatcggag gaaatgtccg gccaggtcac cgacaacacc
4379941 gaatctggtg cgtgctgcac acccgtgccc acccgcacct ctaagaagtc gacgtcgccg
4380001 cggccacgct cccacatccg cggaccgcca atgatggcgc ccagtccggg tgggtccgaa
4380061 tgcacggcgt tctgccattc acgttgcgca cacaccgccg tctggatttc gtcgcggttg
4380121 gtgtccaggt cacgaagata tcgacgacgc cccttctcca actcacccca ggtgatcttg
4380181 cgggctcgac cgaatcgtcc ggagaacgcc agcatgctga acgcgccgat gcccatcagc
4380241 gggaagaacc ccgtggccaa gctgcgcacg cccgacacgt acagcatgac gatggtgccg
4380301 atcagcgcca cgatcaacgc gggaacgccg atcatcaccc agatgttgcg cggctcgcgc
4380361 tccggcagag ctatcggcgg attcggagcc acccgaacgg gtttcggcgg gtcgatgttg
4380421 acgcggttga tgggaaacgc tttcttggac atctaggcgc ccgccttcgc cgttgtcgtc
4380481 acaatggcca cctggccgag ggtgggcaca gtatcgcgag ccaagagtgc cgcatcccgc
4380541 gacagagccg gtcccgcagc aaaagtccgc agcaacggcc acggcgcctg cacggccgca
4380601 cccggatcca ggcccagcgc ccgcagcgtc gcctcgtcgt tggcgatccc gaatcgcacc
4380661 ccattgccgg acacccagaa caacgattcg cgcgactcgg cggtgatcac accgctggtc
4380721 gatgtcacga agttggccgc gccgggcaac accagcacct gggtggccac caccgacgcc
4380781 ggggcgcggt catcgcgtac cagccgcacg atccggctgt ccatcgacgg gggcaccgga
4380841 agcccccgcc cgttgtagac cgcgacccgg gcctgtggat ccgtcgacgc cttctcccac
4380901 gacacgcagg tggtcggatc cgccgcggtg tcaacgaaat tcagccgccc ggccgggtag
4380961 tactccaccg gcagcgaggt cacctgcggt gtgtggacca gcacatcggg ggtcaccacc
4381021 cgcggcgccg ccgccccgta ggagttcgcg ctgcgcagca gatcggccac gaagctgctg
4381081 atcttttgca ccccgtcggg cagcagcaca tagaactggc tgcccccgcc ggcggtttgg
4381141 gcctgcaaca ccgatcccac ccgagcgccc ggcacccacg tcgacggggt gcccgcctcg
4381201 ggcaccgctg gcacccgcag cggctcggtc gcgggcagcc cgtcgaagag cgcccgtgag
4381261 atctgtattg gtgatgtcac gccggggtcg agccccaagc tcaaggtgac cgccctgttg
4381321 gtcggatcga tctgtgagcg tttgccaccc cagatcacgt aggtgctgcc gtcgaaagtc
4381381 accagcagcc cggcgtcgtc gcgcaggtgt gtggcgcggc caccgccggt gatcgggccc
4381441 gcgatcgagg tgaccaccgg cttgtccgcg ctgcgcgggc gtcccgccgt gtcgcacacc
4381501 gcccacgccg agaccgcgcc ccggttcacc ggcatggccg cgggtgcgcc cgggatgccg
4381561 accagcggcc cggtcggata cttggcgatc tcggcgggct tgacccatgt cggctgcccc
4381621 gccgtgccgg tggccagccg cgcggacgtc aagttcagcg ccggatacaa ccggccgtcg
4381681 atgcgcgcgt agagtgcccc ggagtcgcgg tccccgatga tcgccgagtc acccacaatg
4381741 ccggtgggct tgagcacgtt gagcagcatc atccatccgg cggcaatggc caccaacacc
4381801 atcgacaacg ccagcgcggc ggtctgcttg cggtcgtcgt gtttcatgcg caccgagaac
4381861 cgggtggtcg ccgcccgcag ccgccggttg tagaacagat gaccggaatt ttggtcgcgg
4381921 ttggacaaac tcagcggcat tctcaatacc ccctggggct gcggcgagga tcggcctgct
4381981 ggatcagatc ggccagattc gatgcgtcgg cggccacccc gtagtggcct ctcgcgtagt
4382041 tgatgaacgc gcatgcctgg gcgaccaaat cgtggatgtt ggtcgacgtg cccggctcgt
4382101 gataggccgc gaacgtcgga gcgatgaact gccagacgcc cctgctgggg gtgccccgcg
4382161 cggcgttgga atcccagtgg tttatggcgt tggcgttgta gttcgattcg cgacgggcca
4382221 ccaggtccat gccgcgagtc cagcgtgccc gcgcggctgg atcgtgaacg ccttggatat
4382281 ccaacgcttt ttggatcgcc gccaacactt gggcgcgtcc accgggtgtg gttacctggg
4382341 gtcgtcttgc cgcggcggtg cgcaggtagc gcagccggcg cagccgcagc cccaatagcc
4382401 gcgcccgcga cctacatcgc gcgatgtgcc gatgctgagc ccgcagccgg gcggccatcc
4382461 gggccatcgc ctcccgccgg cccagcggtg tgtcggtcaa ggccatggca tcggtcttgg
4382521 cggcttccag gagtgcacgc gtcgcggtcc tggcgtgcgc atgatcgatc tgggctgccg
4382581 ccatgatctg ggccagcgcc tcatcggtgt tggccaatcg acgcagcgct cttgcggcgc
4382641 cgcgccagcg gtacgccgct gcggtgggaa cggcgttggc cacccaggat atcgcgttcg
4382701 catactgctg gatctgcggc gcgtcgatgt cggcgccgga aacgccgccc gcgaacaggc
4382761 cgtggccccg ggacagcgcc gctatcgcct gcgtggtcag gggatcagtc aagggttcgc
4382821 cttcggtgcc aatcctgtgc catgtgctca catccgttgc cgggtgccat cacctcggcc
4382881 gtaccgacca gaccacgacc ttgtcgattg cggccggtgc ccctgcgcca cgaccatact
4382941 gccgttgacg cgacccgact actcagtcgt ggcgcgaagg ccgacctcgc cccagggcga
4383001 ctattcctta accttgtcgt cgttcggcac aacaaggatc cgtcgcgtcg acttggtgac
4383061 caccggcttg tcgtcggcag atttcaccgg aacactcggc ggtactgtta agcggccctt
4383121 gaccggttga ccattcggca cagcccgtca cccgcttctc gaccggcttg tccttattgg
4383181 ctccttccgc gcccgcaccc aacgcgcccg gcggcaccat cggcatgccg gtcatgccgg
4383241 ccggccccga cgcccgcggg gtgccactaa ccgggtccgg cgtcaccgac ttggccggcg
4383301 ccccggctgg agtcgtcggt ggcgacgacg tcggcacggg tgggggaccc agatagcccg
4383361 tcggggtggt gccaccaccc ccgccgccgg cgccgacgtc accagcgccc ggctcgccgc
4383421 cgaggccggg ctcaccttcg atgctgtcca ccagccgcgc cccgtccgcg acgtccagtc
4383481 cctccgcgcc ataggtctgt tgaagcgcac tcatcagcgg ctgcattgct ccctgccccg
4383541 cttgcatggc ctgctgggga agctgcgtga gtgggcccat gacgccgccg accgcgccgc
4383601 cgagcgcgcc ggtaatgccc gacaccgctt gttgcatcat ctgcgtcgcc ccctaggcct
4383661 ccgcctgagc gcccaccccc tggaattgtt gggccgcatc ggcctcattc gccgagaact
4383721 tttgcacggc atcggccgca tgcgcccgcc gatctaggtc ctccaggccg ctggactcga
4383781 cgtcgccggg cacaccggaa ttaccggcgg cgaaaagtgc cccattagcg atgtcggcag
4383841 gtgcgggtag gtctacgggg acagcgggaa acggcgccgg tccggacgct ggcggcgtcg
4383901 tcaaaacctg caataagatt tccggcgtca ccttgatcgg aactcccgga gccgggccgg
4383961 gtgccggatt ctgatctccg gtcatgatca cacctcgaac ttcatccgta gcgccccttc
4384021 ggacgctctt tcgtgtgctt gtcgacattg gccgcagcat cgccattttg tcacgccgcg
4384081 cgtcgaccgg tattcagctc acggtgtcgg gcctcgtatg gtgatcaggg agtttcgggc
4384141 agcggttcag gcagcgaacc ctcgtgagcc gccacgcctg gtggttacgg cataccaggc
4384201 caggtgatag ttggcgaggt agtcctgctc gtcgatcagt gcctcgatcg ccgccagcag
4384261 catccaatcc ccgacagcgg tgagctcgtg actgggatag gccttgagca ccgactcctt
4384321 gaccgcggtg atgcagccgt gcagcagctc ggcttcgttt tccagcacgc cggttttgcg
4384381 taccgccggc agcgcgatcg cctgcgcgat ccgcggcagg ctatcgcggc ggcgcacagc
4384441 ttcgaccaag gtcggcccga actcgtccac cttgggtatc gccgagcgcg ctgaccgatc
4384501 accggtcagc gcaggcgcat ctggccccgg ctcggcaacg taggtgttgg actcgtgggc
4384561 tgccacggcg acgacggcgc ccagcaagtc gatcacgtcg gcatcacggc gtcgcgcggt
4384621 tggctccagc agcgtcacgt tcgcgggcag ccggacgtgg ggcggaatcc acccgccggc
4384681 caaatcggtg accagcaggg tggtggtgcc gtcgtcgcgc agcccggccg cccatgagat
4384741 tcgcggctcc tggcgcgcca cggcatccac gattcgctgt aggcgttgct gctcagccgc
4384801 ccgagccgat accgcgcccg ccgtcgcgcc ggcggtggcc gacagtgccg aggcgccggc
4384861 cattgtcgac gagctcgcac cagcctgtcc agccacagct ttcgaggctg cgcgctccac
4384921 cggagaaacc agcgccccac ccgccgatgg ggccgatgac gccgagggcg ccaccggcgc
4384981 gccggatacg ggcgccgtag gaaccgaggg cacggcgggg gctgccacga cggggggccg
4385041 tagatcagag ccgtaagccg gcagcggtcc cgcggggaca gccgagccac caaccaccgg
4385101 cgcagcgggt gccgccaccg gcccggcggt caccacggtc ggcgcgaccg gcccggtagt
4385161 accggtcgac gccggtggag cgcccgaggt gttcgccggc gtgtcaactg gcccgtgtgt
4385221 ggcttcgatg cccgcagcca tggtcggcgc agacaccacg ggcggtgtcg ttatcggagg
4385281 agtggcctgc ggcgggggaa ccgaccccga ctgcatcgcc gtcattgccc cttccgacag
4385341 cgaatgcgcg ccagccgcgg ccggttgccc cgtcaccatc ccggtcgcaa acgattgccc
4385401 aatcgacgta ggcgatacgc cctgtccgag ggccgccggc gacagcgacc cgccgggcat
4385461 cgccaccggg ggccagtggc gatgactggc ggtgtagcag cggcgggtgt tgtgaccacc
4385521 ggggcaggtg gtacaggtcc tgcgctggcg tgccgactcg aagcgcctat tgctcgcggc
4385581 gccggttgtg agcaggcggc ctggacacca ctgccagaaa agccgccagc acccaccgat
4385641 tgtggcgatg ccaggtctcc ggcgccctca acactcccaa agctaccgcc acgcgcgccg
4385701 ggaccggtca gcgctgccag atcgttctcc ctgatcaggc ggggtggtgg tgcgtcgtcg
4385761 acgttgaaac cattggcccg tgcccacgtc cggggatcgt caccgatatc ttcggcttcg
4385821 aggatctcct gcatggccgt catgaccttg tcgacggcgt cccgggatgc gttcgccgca
4385881 tcggcattgc acctggtttg gatcgcctgg atttccgcca actgctccgg caacggcttt
4385941 ttcgacgcaa gaacgtcgtc gatttcctta tttccttccc ctgcaatgcc ggtcaaccgg
4386001 ctccgcaaat agtcgatggc gtcagcggcg gtattgaagg cgcccttctt tatttcgtac
4386061 ttctctgcct tagtgacctc ggatttcgct ccccgaaggt accggccaat caggtcttcg
4386121 gccgttctac cctgattccg caacaaaaga tcatgttggc tgatcagatt ccttgcgagc
4386181 tcttgctttt gcatggccca agtggcccag tgttgcgcgg cggcacgtag ggccgccgac
4386241 ggggccggcc accacggccc caccagcacc gcgctccacc taccgggcgg aagatcagcc
4386301 gccaccacat acctgcttca tagcagcatc tttcacgttg ccgtcgtcaa gtgcagcctg
4386361 ccactcagct tgagtgccac cactcgccat tacgatcgtt gtgcggtaag cggtcgctag
4386421 cgcgcgcggc gtcgcggtgt ttggcatcta gggcgggatc ggctgctgca ttgtcgagga
4386481 ttgccgcagc atttgtgagc gtgatgcggg ccagtgcctt atcgctcccg ttcgtgtcaa
4386541 ctggtacagc atgggccacc agcttgtatg tgtcgcacaa ttgccgctga gccgcggcag
4386601 tctgggcagc ggtgtaggta ggcaccgagg tcgtagccgg tgtagccgcg ggcctggcgt
4386661 ttgtcagggc cacgatcagc gcagcgaccg ccaccacagc agcgatcgcg gccaccacga
4386721 tggcgggcca actacgtgtg cgtggtatgg gcaagggtgc tggcgcggtc acgccgcaga
4386781 tggtatccgc tgaccgcctg tttgccgctt gcaccagacc acaccaaccc ggacacgccg
4386841 cggcggatgc gttacgtcac cggtgaccac gcggtgcagg tgttccaact gaccagcacc
4386901 gttatcgatc tcaccaccaa gcgcaaacac accacggtcg tgtacgcggc cacctccatg
4386961 tcgggaacgc cacccctgca caggtagcct gctggttgct gggtcattgc gccatgcctt
4387021 cgagaacaaa ttgcatcgga tgcgcgacgt cacctacgca aaacccctcc caagtccgcg
4387081 ctggtcaggg ccccaaggtt agggcacccg cgcaacagcg ccgccggccc gctccgtatc
4387141 gacggccacg acaacatcgc gtccacgcta cgccgcaatg acgcggccct cgccagcccg
4387201 ttaaaccatc acagtcctgt tgaaacgcca ttttgccgag gccttgggcg catcgccggt
4387261 aagcgctgct gaccgcccgg ctgaaatcga tgagcatcac tatcttatct actgttttag
4387321 tatgcggatt gtcgcgacaa tggcatcgca cgagaaacgt caacctaacc cttatagtcc
4387381 ttccaaaggg tgaataaggg cttaccttcg ctatccagga aagaatcctt tatcacgttg
4387441 acagatacgt ctaggtaatg tgacaattca accagtcgat cagccgcggt aattgcaaca
4387501 accgttccac tggaatcgat aagggtatcc cgttgccgac cggcaaacgt catcgtcccg
4387561 atgctatatt ccggcatcag ctcttcgggc tgaaaaggtg cccggatcgc cggcagttca
4387621 cgctcgcttc ggacggagcc tccgaaatac ccgtaaagat atttttcgat cacggacatt
4387681 gatgcagcgg cgaattcata gccttcccgg ctcatgcgat cggatgacgt aataacatac
4387741 catccggcga gccggtcgat aaagtagcgg acttcaccgc ccttgttcca aaggatagtc
4387801 cggccgtcat tcgtttccga cccttggatc atgttcatgc cagataagcg gatccagtcc
4387861 tgcaaatccg ttgacaggtc cacacctatt gtcactgtcg caacaccccg cgccttatta
4387921 actcttccac tttgcgcatc tcgttctgat gatcgaatat ccgcacttgg atggatccgc
4387981 ccggctggcc gcaccccggc gcgacctcag atacttcgat gaaccatccc tcaggcaacc
4388041 aatcaatggt atacgcgtgg taggggtcgc gtaacgacgt cacgtgcagg gcacgttgtt
4388101 cccatgatgc cgggcgccca tgttccatga tcgccaggta cttgccctga tcgccgccta
4388161 tacgatctag ctgggggccg tagtcactaa gaaatttttc gagattagtg taggcgatcc
4388221 ttgtccctgg aaccgcacca ttgttaggcg gaaaattaga gtactgctgg ccccatgggc
4388281 ctacactatt aaatcgctct tgataccgtt cttgggtata gggctgtccc tgaggatcgc
4388341 ggccgaatgg ggcgttgggg tcctccatga gctgggccac aaccgggttt atccgactgc
4388401 gatcggccgg attgtctgta aagtcccagt ggcgcgataa tggctcgcca tactgcgggt
4388461 caaccgcttc gtcggataac cgatgccaac cctctccagc tggttcgttc gaatgcattg
4388521 caagctgctg ctcgcgatgc ggcgcatgca gcccaggtgg ctcgctaccg ctaccgtggc
4388581 ctgacccgtg agacgcaccg tcgtgggtcg gctcggatcc gtgtgcgctc agtgatcggc
4388641 cgtgaggccc cgattcggtt gagtgaacgc ctccgggcgt ggaatgcggc gccgccgcgg
4388701 gtgctgctgg tgtggtcgcc cactggggtt ggtgcgcggt agcgggcgct gactcgacag
4388761 gaggtccgcc aagcaacgtc gtcgccggtg gtgcttgcgc cgggacatgt tcacccggtt
4388821 gcggcaggcc atgcggcaca tgtgtgccgg gcgtggtggc tgcggatacc cggggctggc
4388881 ctgccgacgc cgacgacggc gccaccggtt cagccggtct gtcgacgggc ggcggtttgg
4388941 attcggtggg gctgtgcggc agtggaccgt tggcgggcac gggcgccggt ttcgccgcgg
4389001 gcgcgggtgc cgggtggccc gattctggtg gttcgatccg tggtggttgc ggtcctggcc
4389061 gcggcggcgt tgctgggggc tcaaggtgcg gtgtcgtcgg ctcaagccgc tccttgaggc
4389121 ctcgcacgcc cgcgagaatg tcgcggccct tgctgccaag tttcgacagc ggcccgcccg
4389181 gcaaagctag cgtcgcggcg tcgaatacgg tcttgcctag cgcctcatta gggttggtcg
4389241 tccactcatc ccaatggatg aggcttttgc cgaactgctt ccacgactcc acaacgccgg
4389301 gagcgttctc gccgcccagg cccgccagcg gcgccatccc agtcagcatc tcctcccagg
4389361 agcgatacca cccgaacggg tctatcgagg cgcgcagtgg ccctaggtcc caggagtcct
4389421 tggccatccc gaaggcctcc tcgccgaagc ctttgagctg ctgcccggtg ccatcgatga
4389481 ccacacccac cgggttgctg tgcaagaacc gatcccattg tttgcctgcg tggtctgcca
4389541 tcgcggtgat caccgcctcg gcgtgcgaca ccaccgcggt gatctccgca gccaacgcgt
4389601 ccacttcccc gctgaactgg tcgaccacca ccgcgatgtc atgggcgatg cgctggatct
4389661 cgtcttcgtc ctggtcggtc agaaactccc acacctcttt gatcccggtc agcggatcgc
4389721 agatgcgggc caacaaatcc aggaccgccg catgcaccgc gtcgatgcgg gcggcatagg
4389781 cgtctagctg ggccgccagc tggtggcatt ggcccacgac agcggtggtg ctggcgtacg
4389841 cgtcagcaaa cgccgactcg atcagccccg cctccgggag ctgctgggcg cgaataacgc
4389901 ccatcggccc cgccgtcgac tgaatctcag tcagcgcgaa ctgcgtgccc gcgctgcgcc
4389961 acgccacagc cgccgcacgt agctttgtcg aatccccgtt cggccagatc atcccgatat
4390021 acggggccac ccacccccag cccttcgggg cgccaccgcc gccaccgacc gccgacggcg
4390081 gcgcacccac gccgacacag ccgctcggcg gcggcgccgg caacggcgcc gcccgcccag
4390141 cgacatccga catcgcctcg gccaacgagt agttgtgcgc gctcatgcgc accccatcgc
4390201 cgaggttgca caatccgttg cgcgccaccg acatcgcctg caccagcgcg gccgccgaac
4390261 cgtcatagga gcgcccgaac accgccccag ccggatcatc accggccatc cccgcacacc
4390321 cggccagcgc cgcggtcagc gacgagatca ccgcacccaa acccgcaccc gcagccacca
4390381 ccgcgccgcc cgcgctatca agggccgcgg gatcgaccgc caacggcgcc atcagctcac
4390441 gaccacatac ccaaattcgt ggccatcgcg ccggtgtagt tggcgtgcgc gctctgcccc
4390501 gcggccgtga gctgggccaa cgcctggcgc atcatcgcct caccggcagc ccaatgtcgt
4390561 tgcgcctcag catgagccgc cgcgccctcc cccgtccacg tcacatgcag ccgggtaacc
4390621 aaggactcaa tctcggcgac cagctcctcg acgtggcgac cgaattcggc catccgcgcc
4390681 accgcatcag ccaacacggt cggatccacc cgaaacggct cagccaccgc ccacctcacg
4390741 aagcacctgc gccgacgcgg tctcgttgtg ttgataaccc gcaccggcgt gagctatcgc
4390801 cgccgccagc atcgacaatc ccagctgcac ctcaccggcc ccgcgatgcc atagctccca
4390861 cgccgagcca tacgcactgc ccgacgcccc gcgccacccg cccaacatct gcccgacctg
4390921 agcgtccagc tcggccagtt gaaccgcgag atgctcggcc gctccatcca acgacgcggc
4390981 gaaaccctgc atcaccgcag gctctacgcg cagcgtgtcg tcggcaccca tggccgcaac
4391041 ctaacaatgc ccaggcaccg ccacaattca gccgcccggg cgcacccgcc gcagccctaa
4391101 aggctgctgg cgccgtcggc ggtgccgtcg ccgtcggtgt cggtcagccg tacgtcccag
4391161 cggccgtcgc catcggtgtc gacgtatccg gtcacacgct gctcaccagc acacagcacc
4391221 cgatcggcca gcccgtcacc gtcggtatcg agtagccggt cgtctaaacc accgaacccg
4391281 tcgaagtcaa ccagtggacc accggtgtgc tcgacgccgt cgagcccata ccagcgcagt
4391341 tgtccgccgc ggtcgacggc gaccgcccag gtccccgatc cgtcgtcgat gaagtagctt
4391401 tccggggtgc cgtcgttgtc gacgtcgaat acggcgtggt cggcaacgtc gtcgccgtcg
4391461 aagtcggcca gcgcgtcatc gcgcagaccg tcgccgtcga gatccaggcc aatcgcgtcc
4391521 agccggccgt caccgtcgag gtcgacgtcg aacgggcggt tccagatccc ggcgctgccg
4391581 tcgtcgccgg ctatgcagta ctccacaacc gttctgacgc gactcccaag ctagcggttc
4391641 ccccgtgatt tccaccagga cagcagctcg gttgtcgcct cctcggtgga caacgggccg
4391701 cgctctagcc gcagctcctt caagtagcgc cacgcctcgc cgacttgcgg gcccgccgga
4391761 atgtcgagca ccgccatgat ctggttgccg tccaggtcgg ggcgcacccg atccagatcc
4391821 tcctgggcgg ccagctccgc gatccgctct tccagccggt cgtaactggc ctgcaaccgc
4391881 gcggcccggc gcttgttgcg ggtcgtgcag tcggcgcgca ccagcttgtg cagccgtggc
4391941 agtagggccc cggcgtcggt gacatagcgg cgcaccgcag agtcggtcca tttcccatcg
4392001 ccgtagccgt gaaaccgcag atgcaggtag accagctgcg agatgtcgtc gatcatctgc
4392061 ttggaatact tcagcgcccg catccgcttg cgcaccatct tggcgccgac cacttcgtgg
4392121 tgatggaagc tcaccccacc gtcgggttcg tgacggcggg tggcgggctt gccgatgtcg
4392181 tgcagcagcg ccgcccagcg caacaccaga tccgggccgt cgtcctccag cgcgatcgcc
4392241 tgccgcagca cggtcaagga atgctgatag acgtccttgt gctggtgatg ttcgtcgatc
4392301 gccatccgca tcccaccgat ttcaggcaag accacagcac ccataccgct ctgcaccatc
4392361 aggtcgatac ccgcggccgg atcctcaccg accagcagct tgtccagctc ggcggccacc
4392421 cgttcggcgc tgattcgggc caactgcggc gccatctctt cgatcgccgc gcgcacccgc
4392481 ggcgccaccg cgaatccaag ttgcgagacg aaccgcgcgg cgcgcagcat ccgcaacgga
4392541 tcgtcgccaa aggaccccga cggcgccgcc ggggtgtcta acaccttggc ccgcagcgcc
4392601 gccaagccac caagcggatc caggaattcg cccggcccag tggcggtgac gcgcacagcc
4392661 attgcgttcg tggtgaagtc gcggcggacc agatcgccct cgaggcaatc gccgaaacgt
4392721 acctctggat gacgcgaaac ccggtcgtag ctgtcggcac ggaatgtggt gatctccatg
4392781 cggtggtcgc tcttacccac gccgacggtg ccgaattcga ttccggtatc ccacaccgca
4392841 tcggcccacg gccgcacgat ctcctgcacc cgctcgggac gggcgtcggt ggtgaagtcc
4392901 aggtcggggc tcaaccggcc caacagtgca tctcgcaccg aaccgccgac cagatacaac
4392961 tcgtgtcccg cggcggcgaa caccgacccg agttcccgca ataaggcagc atgcctgttc
4393021 aaggcaaccg cagcggcggt tagcagatcg gcttcctgga cggcttccgg cacgttcgat
4393081 cagcctaatg gcagtcgaag tgggccggga cggtcggtgg aggaaccggc aaccctcgtt
4393141 gccgcacccg tcgcattggc cggtgtcggg acgaggtatc gtcgtgccca tctccgcgcg
4393201 acaaacagcc ggcgacaata ttaagaatcc ttgggtgcgg tcgcgtcttg tcgctcgaag
4393261 gtgggcaaat cgtgcgcccc cgacacagcg acttctgtga tagatgtgac tggcgcgact
4393321 caattggtca gcgcgggtcg cctgcaccgc cccgctccct cgcccaacga ataagtcctg
4393381 gccgacgatg ggcgctcaga cggcgagtac atcgggaaca cccgcccgta ccagctacta
4393441 tcgctggggt gtccgacggc gaacaagcca aatcacgtcg acgccggggg cggcgccgcg
4393501 ggcggcgcgc tgcggctaca gccgagaatc acatggacgc ccaaccggcc ggcgacgcca
4393561 ccccgacccc ggcaacggcg aagcggtccc ggtcccgctc acctcgtcgc gggtcgactc
4393621 ggatgcgcac cgtgcacgaa acatcggctg gagggttggt cattgacggt atcgacggtc
4393681 cacgagacgc gcaggtcgcg gctctgatcg gccgcgtcga ccggcgcggc cggctgctgt
4393741 ggtcgctacc caaggggcac atcgagttgg gcgagaccgc cgagcagacc gccatccgcg
4393801 aggtcgccga ggagaccggc atccgcggca gtgtgctcgc cgcgctgggg cgcatcgact
4393861 actggttcgt caccgacggc cggcgggtgc acaagaccgt ccaccattat ttgatgcggt
4393921 ttttaggcgg agagctgtcc gacgaagacc tcgaggtagc cgaggtagcc tgggtgccga
4393981 tccgggaact gccgtctcga ctggcctacg ccgacgaacg tcgactagcc gaggtggccg
4394041 acgaactgat cgacaagctg cagagcgacg gccccgccgc gcttccgccg ctaccaccca
4394101 gctcgcctcg tcgacggccg caaacgcatt cacgcgctcg tcatgccgat gactcagcac
4394161 cgggtcagca caacggtccc gggccggggc cgtgaccgca ctgcaactcg gctgggccgc
4394221 tttggcgcgc gtcacctcag cgatcggcgt cgtggccggc ctcgggatgg cgctcacggt
4394281 accgtcggcg gcaccgcacg cgctcgcagg cgagcccagc ccgacgcctt ttgtccaggt
4394341 ccgcatcgat caggtgaccc cggacgtggt gaccacttcc agcgaacccc atgtcaccgt
4394401 cagcggaacg gtgaccaata ccggtgaccg cccagtccgc gatgtgatgg tccggcttga
4394461 gcacgccgcc gcggtcacgt cgtcaacggc gttacgcacc tcgctcgacg gcggcaccga
4394521 ccagtaccag ccggccgcgg acttcctcac ggtcgccccc gaactagacc gcgggcaaga
4394581 ggccggcttt accctctcgg ccccgctgcg ctcgctgacc aggccgtcgt tggccgtcaa
4394641 ccagcccggg atctacccgg tcctggtcaa cgtcaatggg acacccgact acggtgcgcc
4394701 tgcgcggctc gacaatgcgc ggttcctgtt gcccgtggtc ggagtgccac ccgaccaggc
4394761 caccgacttc ggctccgctg ttgcaccaga aacgacggcg ccggtctgga tcaccatgct
4394821 gtggccgctg gccgaccggc cccggttggc ccccggggca cccggtggca ccgttcccgt
4394881 ccggctggtc gacgacgacc tggcaaactc gctggccaac ggcggccggc tggacatcct
4394941 cctgtcggcg gccgagttcg ccaccaaccg ggaagtcgac cccgacggcg ccgtcggccg
4395001 agcgctgtgc ctggccatcg acccagatct actcatcacc gtcaatgcga tgaccggcgg
4395061 ctacgtcgtg tccgactcgc ccgacggggc cgctcaacta ccgggcaccc cgacccaccc
4395121 gggcaccggc caggccgccg catccagctg gctggatcga ttgcggacgc tagtccaccg
4395181 gacatgcgtg acgccgctgc cttttgccca agccgacctg gatgctttgc agcgggttaa
4395241 tgatccgagg ctgagcgcga tcgcaaccat cagccccgcc gacatcgtcg accgcatcct
4395301 ggatgtcagc tccacccgcg gcgcaaccgt gctgcccgac ggcccgttga ccggccgggc
4395361 gatcaacttg ctcagcaccc acggcaacac ggttgccgtc gcggccgccg attttagccc
4395421 cgaggaacag cagggttcgt cccagatcgg ctccgcgctc ttacccgcta ccgcgccccg
4395481 gcggttgtcc ccgcgggtgg tagcggcgcc gtttgatccc gcggtcgggg ccgcgctggc
4395541 cgccgcggga acaaacccga ccgttcctac ctatctagat ccctcgttgt tcgttcggat
4395601 cgcgcatgaa tcgatcaccg cgcgccgcca ggacgccttg ggcgcaatgc tgtggcgcag
4395661 cttggagccg aatgccgcgc cccgtaccca aatcctggtg ccgccggcgt cgtggagcct
4395721 ggccagcgac gacgcgcagg tcatcctgac cgcgctggcc accgccatcc ggtctggcct
4395781 ggccgtgccg cgaccactac cggcggtgat cgctgacgcc gcggcccgca ccgagccacc
4395841 ggaacccccg ggcgcttaca gcgccgctcg cggccggttc aatgacgaca tcaccacgca
4395901 gatcggcggg caggttgccc ggctatggaa gctgacctcg gcgttgacca tcgatgaccg
4395961 caccgggctg accggcgtgc agtacaccgc accactacgc gaggacatgt tgcgcgcgct
4396021 gagccaatcg ctaccacccg atacccgcaa cgggctggcc cagcagcggc tggccgtcgt
4396081 tggaaagacg atcgacgatc ttttcggcgc ggtgaccatc gtcaacccgg gcggctccta
4396141 cactctggcc accgagcaca gtccgctgcc gttggcgctg cataatggcc tcgccgtgcc
4396201 aatccgggtc cggctacagg tcgatgctcc gcccgggatg acggtggccg atgtcggtca
4396261 gatcgagcta ccgcccgggt acctgccgct acgagtacca atcgaggtga acttcacaca
4396321 gcgggttgcc gtcgacgtgt cgctgcggac ccccgacggc gtcgcgctgg gtgaaccggt
4396381 gcggttgtcg gtgcactcca acgcctacgg caaggtgttg ttcgcgatca cgctatccgc
4396441 tgcggccgtg ctggtaacgc tggcgggccg gcgcctttgg caccggttcc gtggccagcc
4396501 tgatcgcgcc gacctggatc gccccgacct gcctaccggc aaacacgccc cgcagcgccg
4396561 tgccgtagcc agtcgggatg acgaaaagca ccgggtatga gaccctcccc tggagaggtg
4396621 cccacggcat cgcagaggca gcccgagctg tccgacgcgg cgctggtatc gcactcctgg
4396681 gcaatggcat tcgcgacgct gatcagccgg atcaccggct ttgcccggat cgtgctgctg
4396741 gccgcgatct taggtgcggc gctggccagc tcgttctcgg tggccaacca gctgccgaac
4396801 ctggtcgccg cactcgtgct ggaggccacc ttcaccgcca tcttcgtacc ggtgctggcc
4396861 cgcgccgagc aggacgaccc ggacggcggc gcggcgttcg tgcgccgttt ggtcacgttg
4396921 gcaaccaccc tgctgctggg cgccaccacg ctgtcggtgc tggccgcgcc actgcttgtg
4396981 cggttgatgc tgggcacaaa cccacaggtt aacgagccgc tgaccacggc gttcgcttac
4397041 ctgctgctac cgcaagtcct cgtctacggc ctctcgtcgg tattcatggc gatcctgaac
4397101 acccgcaatg tgttcgggcc gccggcctgg gcgcccgtcg tcaacaatgt cgtcgccatc
4397161 gcgaccctag cggtgtatct ggcggtcccc ggcgagcttt cagtcgatcc ggttcggatg
4397221 ggcaacgcca agctgctggt gctcggcatc ggcaccaccg caggcgtgtt tgcacagacc
4397281 gcggtgctgc tggtggccat ccggcgcgag cacatcagcc tgcgccccct gtggggaatc
4397341 gatcagcggc tcaagcgctt tggcgcgatg gccgccgcga tggtgctcta tgtgctgatc
4397401 agccagctcg gcctggtggt cggtaaccgg atcgccagca cggcagcggc ttccggcccc
4397461 gcgatctaca actacacctg gctagtgctg atgttgccat tcggcatgat cggcgtgacg
4397521 gtgctgaccg tggtgatgcc gcggctgagc cgcaatgccg cggccgacga taccccggcc
4397581 gtgctcgccg acctgtcgct agccaccagg ctgaccatga tcacgctgat cccaacggtg
4397641 gcgttcatga cggtcggcgg tccggcgatc ggtagcgcgc tttttgcata cggcaacttc
4397701 ggcgacgttg atgccgggta cctgggggcg gcgatcgcat tgtcggcgtt cacgttgatc
4397761 ccctatgcgt tagtgctgtt gcagctacgc gtgttctacg cccgcgagca gccgtggaca
4397821 ccaatcacga tcatcgtggt catcaccggc gtcaagatcc tcggctcgct gctggcgccg
4397881 catattaccg gtgatcccca gctggtcgcg gcctatctcg ggctggctaa cggactcgga
4397941 tttctcgccg gcacgatcgt cggctactac atactgcgtc gggccctgcg gcccgacggc
4398001 ggccagctga tcggcgtcgg cgaggcgcga accgtcctgg tgaccgtcgc cgcgtcgttg
4398061 cttgccggac tgctggcaca cgtggccgat cggttactag ggctaagcga gctgacggcc
4398121 cacgcgggca gcgtcggttc gctgctgcgg ctgtcggtgc tggctctcat catgctgcca
4398181 attctggctg cggtcaccct ctgcgcacgg gtgcccgagg cgcgggcggc gctggatgcc
4398241 gtgcgagccc gaatcaggag ccggcgcttg aagaccgggc ctcagaccca gaatgtcttg
4398301 gatcaatcgt ctcgccccgg accggtcacg taccctgagc ggaggcgttt ggccccgccg
4398361 cgggggaaaa gtgtggtcca cgagccgatc cggcgcaggc ctccggagca ggtagccaga
4398421 gccgggagag cgaaaggacc ggaggtgatc gaccgcccat cggagaacgc ctcgtttggt
4398481 gccgcgtcgg gtgccgagct gccgcggccc gtcgccgacg agcttcagct cgacgcgcca
4398541 gccggccgtg accccggccc cgtttcccgg ccgcacccat ccgacctgca aaacggcgat
4398601 ctgcccgccg atgcggcccg tgggccgatt gcgttcgacg cgctccgcga accggaccga
4398661 gaatcgtcgg cccccccaga tgatgtgcag ctggttcccg gcgcccgcat cgctaacggc
4398721 cgctaccgcc tgctgatctt ccacgggggt gtaccacccc tgcagttctg gcaggcgctt
4398781 gacacagcgc tggaccgcca ggtggcgctg accttcgtcg acccgcaggg cgtcctgccc
4398841 gacgacgtcc tccaggagac cttgtcccgt acgttgcggc tcagccggat cgacaagccc
4398901 ggtgtcgccc gagtgcttga cgtcgtgcac acccgggccg gtggtctggt agtcgcggag
4398961 tggatccgcg gcggttcgtt acaggaagtc gccgacacct caccgtcgcc ggttggcgcc
4399021 atccgggcga tgcagtccct ggccgcggcc gcagatgctg cccaccgcgc cggtgttgcg
4399081 ctgtcgatcg accatcccag ccgggtgcgc gtgagcatcg acggcgacgt cgtgctggcc
4399141 tacccggcga ccatgccgga cgccaacccg caagacgaca tccgcggcat cggcgcctcc
4399201 ctgtacgccc tgctggtcaa ccggtggccg ctgccggagg ccggcgtgcg cagcgggttg
4399261 gcacccgccg agcgcgacac cgctggccag cccatcgaac ccgccgacat cgaccgtgac
4399321 atccccttcc agatttccgc ggtggcggcc cggtcggttc aaggagacgg cgggatacgc
4399381 agcgcgtcaa cgctgttgaa tctaatgcag caggcgaccg cggtggccga tcgcaccgag
4399441 gtgctgggac cgatcgacga agcaccggtc tccgcggccc cgcgcacatc cgcgcccaac
4399501 agcgaaacct acacccgccg ccgtcgcaac ctgctgatcg gcatcggcgc gggtgctgcc
4399561 gtcctcatgg tggccctgct ggtcttggct tcggtgttga gccggatatt cggcgatgtc
4399621 agcggcggcc tcaacaagga cgaactgggc ctcaacgcac ccaccgcgtc gacctcggcg
4399681 gccagttcgg cgccgcccgg cagcgtcgtc aaacccacca aggtcacggt cttctccccc
4399741 gacggcggcg ccgacaaccc cggggaggct gatttggcca tcgacggcaa tccggccact
4399801 tcctggaaga ccgacatcta taccgacccc gtcccgttcc ctagcttcaa gaacggagtc
4399861 ggtttgatgt tgcagctgcc ccaggccacg gtggtcggca ccgtcgccat cgacgtggcc
4399921 agcaccggca ccaaggtgga gatccgctcg gcatccacgc cgacgccggc aacgctggag
4399981 gataccgccg tgttgacttc ggccaccgcg ctgcggcccg gccacaacac catctcggtc
4400041 gaggcggccg cgcccacctc gaatctgctg gtgtggatct ctaccttggg aaccaccgac
4400101 ggaaagagtc aagccgacat ctcggagatc acgatttacg ccgcgtcctg accgggccgg
4400161 gcacggccag ccagggtgaa gtgctatgcc gccaccgatt ggttactgtc cggccgtggg
4400221 tttcgggggc cgtcacgagc gcagcgacgc cgagctgctg gccgcccatg tcgccggcga
4400281 ccggtacgcc ttcgatcagt tgttccgccg tcatcaccgc cagctacacc ggctcgcgcg
4400341 gctcaccagc cggacctccg aggacgccga cgatgcgctg caagacgcga tgctgtcagc
4400401 gcaccgcggc gccggctcgt tccggtacga tgccgccgtc agcagttggt tgcaccgcat
4400461 cgtggtcaac gcttgcctgg accggctgcg tcgggccaaa gcccatccga ccgcccctct
4400521 agaagatgtc tatccggtcg cggaccggac cgcgcaggtc gagaccgcga tcgcggtgca
4400581 gcgggcactg atgcggctgc ccgtcgagca gcgggccgcg gtggtcgccg tggacatgca
4400641 gggctattcg atcgccgaca cccgcccgga tgctgggcgt ggccgagggc accgtcaaga
4400701 gccgctgcgc ccgggcgcgg gcccgcctag cgcggctgct gggctatctc aacaccgggg
4400761 tgaacatccg gcgctgaccc cgttgccggt ccgtcgtagc atcgatccac gggctcgccg
4400821 ctaccccaca tctggctatt gccaccgggc atgacggaca ctggggccga tgagtgcagc
4400881 cgacaaggat ccagacaaac atagcgccga tgcggacccg ccgctgaccg ttgagctgct
4400941 ggccgacctg caagcaggtc tgctggacga cgcaaccgcc gcccgcatcc gcagccgggt
4401001 ccgctcagac ccgcaggctc agcaaatcct gcgcgcgttg aaccgggtac gccgcgatgt
4401061 cgccgcgatg ggtgccgacc ccgcttgggg gccagctgct cgcccagcgg tcgtcgacag
4401121 catttcggcg gccttacggt cggcgcgccc gaacagctca cccggcgccg ctcacgccgc
4401181 ccgtccgcac gtccaccccg tccgaatgat cgccggcgcg gccggattgt gcgccgtggc
4401241 cacagcgatc ggtgtcggcg ccgtggtcga tgcaccgcca cccgcaccga gtgcaccgac
4401301 aaccgcgcag cacatcacgg tgtcaaaacc tgccccggtg attccgctgt ctcggccgca
4401361 ggttctcgac ctgcttcacc acaccccgga ctatggccca cccggaggcc cgctgggcga
4401421 tccgtcccgg cgtacgtcct gcctgagcgg cctcggctat ccggcgtcca cgccggtgct
4401481 gggcgcgcag ccgatcgata tcgacgctcg gcccgccgta ctgctggtga tacccgcgga
4401541 cacgcccgac aaactggccg tttttgcggt cgcgccgcac tgcagcgccg ccgataccgg
4401601 gttgttggct agcaccgtgg tcccccgcgc atgatgggtc tgggtgctgt cgctcgcctg
4401661 cgggaacagc agtgcctacg ctggcgttcg ttgtctcaag atctgccctc gcactcgaaa
4401721 ggctcgcatg accgccccgc ctgtccatga ccgcgcacac caccccgttc gcgacgtgat
4401781 cgttatcggc tccggtcccg cggggtacac tgcggcgctc tacgccgccc gtgcccagct
4401841 ggcgccgctg gtcttcgagg gcacgtcttt cggcggcgcg ctgatgacca ccaccgacgt
4401901 ggagaactac ccgggatttc gcaacggcat caccggtcca gagttgatgg atgagatgcg
4401961 ggaacaggcg ctgcgattcg gcgcggacct gcgtatggaa gacgtcgagt cggtatcact
4402021 tcacgggccg ctgaaatcgg tcgtcaccgc cgacggacag acccaccggg cccgagccgt
4402081 gatcctggca atgggcgcag cggcacgcta tctgcaggtg cccggcgaac aggaattgct
4402141 cgggcgcggg gtgagctcgt gcgccacctg cgacggattc ttcttccgcg atcaggacat
4402201 cgccgtcatc ggcggcggtg actcggcaat ggaggaagct accttcctga cccgattcgc
4402261 tcgcagtgtg acgctggtgc atcgccgcga cgagttccgg gcttccaaaa tcatgctcga
4402321 tcgcgcccgc aacaacgaca agatacggtt cctcaccaac cacaccgtgg tcgcggtgga
4402381 cggggacacc acagtgaccg gcttgcgggt acgcgacacc aacaccggtg ccgaaaccac
4402441 cctgccggta accggtgttt tcgtcgcgat cggccacgag ccgcggtcgg gcttggtgcg
4402501 cgaggccatc gacgtcgacc cggacggcta cgtgttggtg caggggcgta ccaccagcac
4402561 ctcactgccg ggcgtgttcg ctgccggcga cctggtggat cgcacctatc gccaggcggt
4402621 taccgcagcg ggcagtggct gcgccgcggc tatcgacgcc gagcgctggc tcgccgagca
4402681 cgcagcaacc ggagaagctg acagtaccga cgcattgata ggagcacaac gatgaccgat
4402741 tccgagaagt ccgccaccat caaagttacc gacgcatcct ttgccaccga cgtgctatcc
4402801 agcaacaagc ctgtgctggt tgacttttgg gcgacatggt gtggaccttg caagatggta
4402861 gcgcccgttc tcgaggaaat cgccaccgag cgcgcaacag acctcaccgt cgccaagctc
4402921 gacgtggaca ccaacccgga gaccgcccgc aacttccagg tcgtctcgat ccctaccctg
4402981 atcttgttca aggacggcca gccggtgaaa cgaatcgttg gcgccaaggg taaggctgcg
4403041 ttgctgcgcg agctctcaga cgtggttccc aacctcaact agcccccgcg gttagcctgg
4403101 ggttttcccg aaatcggcaa ggatctgcga caataccggt tggctggtcc gcattgtcaa
4403161 cgatgtgagc taatcccgga gggcccttgg tatgccgagt ccgcgccgcg aagacggcga
4403221 tgcgctgcgc tgtggcgacc gcagtgcggc cgtcaccgag atccgggctg cgctgaccgc
4403281 gttagggatg ctggatcatc aggaagaaga cctgacgacg ggccgtaacg tcgcccttga
4403341 gttgttcgac gcgcagctcg accaggcggt ccgtgccttc caacagcatc gcggcctgct
4403401 ggtggacggc atcgtcggtg aggccaccta ccgcgcgttg aaagaagcct cctaccggct
4403461 cggggcccgc acgctgtacc accaattcgg cgccccgctc tacggggacg acgtcgctac
4403521 actgcaggcc cggctgcagg atcttggttt ctacaccggg ctggtcgacg gtcatttcgg
4403581 gttgcagacc cacaatgcgt tgatgtccta tcagcgtgag tacggacttg ccgcagacgg
4403641 tatctgcggc ccagaaacgt tgcgctcctt gtactttcta agttcgcgag tcagcggtgg
4403701 ctcgccacat gcgattcgcg aagaagagct ggtccgcagc tcggggccga agctgtctgg
4403761 caaacggatc atcattgatc ccggtcgcgg cggcgtggac cacggactta tcgcgcaagg
4403821 tccggctggg cccatcagcg aagcagactt gttgtgggac ttggcaagtc ggctcgaagg
4403881 acggatggca gctatcggta tggagaccca cctgtcccgt ccgaccaacc gtagtccgtc
4403941 cgacgcagag cgtgccgcca ccgccaacgc cgttggcgca gacctgatga tcagcctgcg
4404001 ctgcgagacc cagaccagtc tcgcggccaa cggcgtggct tcctttcact tcggcaactc
4404061 gcacggctcg gtgtctacca tcggccgcaa tcttgccgat ttcattcaac gagaagtggt
4404121 ggcgcgcacc ggtttacggg attgccgtgt gcatggtcga acgtgggatc tgttgcggct
4404181 gaccaggatg ccgaccgttc aggtcgatat cggctacatc accaaccccc acgatcgtgg
4404241 gatgctggtc tcaacgcaga cgcgcgatgc catcgccgaa ggcattctcg ccgcggtcaa
4404301 acggctgtat ctgttaggca agaacgatcg gcccaccggc acattcactt tcgccgagtt
4404361 gctggcccac gaactgtctg tcgagcgagc gggtagactc ggcggttctt aagcccagtg
4404421 gccgcgtggg gtttacgacg tgttgccggc cgtcgacccc gctgctatcg gctcttgcag
4404481 tcgagcattc tccagcaagc gttcaagagc ggcctcgact tcggctttcc accccagccc
4404541 tttgtccagt tcgaggcgta gcctcggaaa gtacgggtgc ggtgccacca cgacgaaacc
4404601 cacgtccatc aagaagttcg cgtcgatgat gcagtgttcg acacagcagt cgccgagggc
4404661 ctccaacacc ggccgcacat caggtgttac cgcgcccggg ttttgcaaat cggtggccgc
4404721 tggtgtccgg ccgaaagctt ccagcgcccg gacgccgcgc cgaaccaact cttcaatcac
4404781 ccgggcaatc agactgtgcg gtaagtcgtc atctgcttgc ccgcgctcga tgcccatcga
4404841 cgtaagcagc accgcgtccg ccgacaccgg cgcggtagga aaccgctggg ctcgcggcac
4404901 cgcactgggc ggagcgtaga gcacataccc gaggcagggt ggttcggcgt ggctgcgctc
4404961 atccgggact gccgttgcga cctgaccgca cgaaccccac tccagcatca ccatcgacaa
4405021 ccaggcttcc ttttcgaatt cggggtcggc gaggtggtcg tctttgccga gaatcgcggg
4405081 gtcgacctcc cagaaaacgc agcgtcgcgc atgcttgggg agctgctcga aggcttcgag
4405141 tcgtaacgct gtgatacgag cggacactag tctcctggcc tccgtgcggc attgcaaccg
4405201 atggccctac acctccgcgg gccaatgtgc accagcaacc cttctagaat aagagagtcg
4405261 atcgctatcg ggccagtatt cgcgatgcca ctccagccga cttgcaccgc atcgtgtccg
4405321 gccggtgaca attgtccggt ccattgcccc gtccaatctc gaatccgctt gccgcacacc
4405381 gcgtctccgt tgattcccgc tccccgcagc gggttggctt aggcgccgga accggcgcgt
4405441 tgtcacagtg acgtaattac agagcgtccc tgtgcaggcc tttatctcgg ccatcagtgg
4405501 tcatcaaacc gactatgcgc gctaaatcat cgaccgagcc gaactccacc acaatcttac
4405561 ccttgcgttt gcccagactg acggtcaccc gcgtgtcaaa ggtggtcgat agacgctcag
4405621 caacatcttg gaggccaggc atctgaatcg gcttacgccg cggcggcgcg ggtgtagtcg
4405681 cgtcgctgtg atgggcttgg cgattggcct cgtgattggc cagcgtgacc gtctcctcgg
4405741 tggctcgcac cgacaggccc tccgcgacga tccggctcgc cagctcctct tgcgcctccg
4405801 gtccggcctc gagcgacagc agggcgcgag catgcccggc cgacagcacg ccggcggcca
4405861 ctcgccgctg taccgggatg gggagtttga gcaatcggat catgttggtg atcaagggcc
4405921 gcgagcggcc gatgcgcgcc gccagttcat cgtgggtgac cccgaattcg tcgagcaatt
4405981 gctggtatgc cgccgcttct tctaacggat tcagctgtac tcgatgaata ttttccagga
4406041 gggcgtcgcg cagcagatta tcgtcgccgg tctcacgcac gatggccggg atggtggcca
4406101 agcccgcctc ttgggcagcc cgccagcgcc gctcccccat cactatctgg tagcgcacgc
4406161 cggtttggga tccagccaat gaccgcacca cgatcggctg caggagaccg aattcgcgga
4406221 tggagtgcac caactcggcc agtgcctctt cgtcgaacac ctgacgcggc tgacggggat
4406281 tagcctcgat ggcgctcggt gggatttccc gatagatggc gcccatcacg gaagtgtccg
4406341 ggaccggtcc gccgattacg acatctgccg tggcagatcc catccgggga cccaaggtcg
4406401 gtggccccga ttctccgtct gccgggccag tcgggatcag cgcagccagg ccacggccga
4406461 ggccaccctt tctgcgtgac ggctgggtca tggtcgtccc ttcgcggatg gtggtcggtc
4406521 acgctcggca agttcgcggc tcgcgtcgag gtaactcatc gcgccgcgcg aaccgggatc
4406581 gtaatcgatg atggtcatgc tgtagcccgg cgcttcggaa accttgacgc tgcgtggaat
4406641 caccgtccgc aacactttgc ttccgaaata ctgacggacc tcgtcggcta cttgatcggc
4406701 gagctttgtc cggccgtcat acatggtaag gatcacggtg gtgacctcga gttgggggtt
4406761 gaggtgggcc ttcaccatct cgatgttgcg cataagctgc gacacaccct ccaacgcgta
4406821 gtactcgcat tggatcggga tcatcacctc cggtgccgcg acgagtgcgt tgatggtcag
4406881 cagccccagc gagggcgggc aatcgacgaa aacgtagtcg aagtcgaagt tgtcgagtgc
4406941 ggccagggcg gtgcgcaacc ggttctcgcg cgccaccatg ctcaccaatt cgatttcggc
4407001 gccggccaga tcgatcgtcg ccgggatgca gaacagccgc tcgctgtgcg ggctgcgccg
4407061 tagcgccgtg tgcaacgaaa cctcgccgat aagcatctcg taggacgagg gtgtgccgga
4407121 ttgccggtcg gtgataccca atgcggtgct cgcgttgccc tggggatcga gatcgatcac
4407181 gagtgtcttg aggccctgca cagcaagcgc ggcagcgata ttgacggcgg tggtcgtctt
4407241 accgaccccg cccttctgat tcgcgatggt gagcacccgg cgtcgacccg gccgctgcag
4407301 cggctcgtgg gtggtgtgca ggacccgcat cgcacgttct gctgcagcgc cgatgggggt
4407361 gtcgaattct gtcgatgttt cacgtgaaac attcatcgtc ggattgtgcg cggcctcagg
4407421 cgtcggtgtc ggtggtgtca tttcccgctg gaatggttcg atagttgaag cctggcccga
4407481 ccttacgagc gcggacggtc cagcggccac cgggccccac ggagcactca cgccgtccct
4407541 ccactcgcca tccgtgccga ccctcgggcg atctgctttc cacgtcgtgc gaacaccacg
4407601 gtcgcgggcg gacgcaaata gttcgcgcca catgtcacca ccctgacatc aaccgcgccc
4407661 gatgcgatca tcacacgccg gtgctcccgt acttcgtcgt gagcccgctc gcctttgatg
4407721 gcgagcattc gcccgttcgg ccgtatcaac ggcatgctcc atttcgtcaa cttgtccaac
4407781 gcggccaccg cccgtgacac cgcagcgtcg ctgccgccca attggtcctg cacccaggac
4407841 tcctcggcgc gcccccgcac gatctcaacg gccacgccca gatctgtcac catctctcga
4407901 agaaactcgg tgcggcgcag tagcggttct aggagaacta cctggaggtc cggccgcgct
4407961 atcgccaatg gcacgcccgg caacccggct ccgctaccga tatccacgac ccggtcaccg
4408021 cgttcgagga gctcaccgat cacggcgcag ttcagtagat gccggtccca tagcctaccg
4408081 acttcgcggg gtcccaccag cccccgctcc acaccgggtc ccgccaacgc ttcggcgtac
4408141 cgccgagcaa ggccaagccg cggtccgaag atcgcagacg ccgcgggctc gatcggagac
4408201 attacgcact ccgccggctc gtgaggtctg tgtcatgttt cacgtgaaac attctccgct
4408261 ctcgagacgc tggcccagcc gctcggccac gcatcgctta ctgcggcgtc ggtcggagcc
4408321 gctggctcgc gagctagtcg cggagcacaa cgactcggcg ttctggctcc acgccttcgc
4408381 tttcgctgtg cacacctggc accgctgcaa ccgcatcgtg gacgatcttc cgttcgaacg
4408441 gcgtcattgg aacgagttcc tcgcggtcac cggtttcggc cactcgccgc gccacctcgt
4408501 cggccagcgc cgccaattcc tcccggcgcc gccgtcgcca cctcgcgatg tctagcatca
4408561 accggctccg cacaccggtc ttctgatgca ccgccaaccg ggtgagttcc tgcagagcgt
4408621 cgagcacctc gcccccgcgc ccgaccaact tgttcaggtc gtcactgccg tcgatgctca
4408681 ccaccgcacg attgccttcg acatcgaggt cgatgtcgcc atcgaagtcc aacacgtcca
4408741 ataactcttc caggtagtcg cctgcaatct cgccctcggc gaccaatctc tcttcttgat
4408801 cgtcggcctc gtcagcatcc gtcgccgtgt cctcccggac gcctccaccc ggtgcttctg
4408861 cgtcgacgtc gaagtcggtg gtgtcagcgt cggccatggc ttgctctccc ctcgtctgca
4408921 ggcgggttgt gtttgtggga ccgcctgccc ggctgcccgg aaggattgtc aacgtttgcg
4408981 ttttttcggt cgcaccccgg gccgcggcgt acgggcgctc gggccgctgt tgcgtctggc
4409041 cggattggac gtgtcggctg gtcgctcagt gctggcgtcc gactctgccc cgtcatcggt
4409101 gtccccggct tctgttgggg ctgccgcatt ggtcgctgga gcggtcttcg ggctccgctt
4409161 gggcttagct cccggggccg gcgcgttggc cgcccggcgc cggaccgcct cctgcttttt
4409221 ggcctcctcc tccttttcga tcatgccgaa gacgtaatgc tgctgcccga acgtccagat
4409281 attgttcgag aaccaataca agatgatcgc cagtggcagg aacggtccgc cgacgactac
4409341 gccgagcgga aatacgtaca gcgccagctt gttcatcatc gcggtctgtg gattcgcagc
4409401 cgcctcggcg ctctgccgcg cgatagacgc gcgactgttg aagtacgtcg cgatgccggc
4409461 caagatcatc accggcacac ccaccgcgat caacgcaggg cgactgaaat cgacgaacgc
4409521 atccaacccg gaccgttgcg tcatgtacgc cccgatcgga gcgccgaaca agttggcatc
4409581 taggaagtgg ccgacgtcga ccgggctaaa gacgtagttc ccagtcagtc ggttctcgat
4409641 caccgacaag tgtggttgac caaagccccc ggtcgtacgg ttaaacgagc gcaacacatg
4409701 atagagccca agaaacaccg gaatctgcgc cagcatcggc aaacatccga gaatggggtt
4409761 gaagccgtgc tcgcgttgca gcttttgcat ttcgagcgcc atccgctgac gatccttgcc
4409821 gtatttcttt tgcaaggcct tgatctgtgg ttgcagttcc tgcatctgcc tggtggtgcg
4409881 aatctggcgc acgaacggct tgtacagcag cgcacgcagc gtgaagacca ggaacatcac
4409941 cgacaacgcc caggcgaaga agttggatgg tcctagcaca aacgcgaaca gccggtacca
4410001 aacccacatg atccacgaca ccgggtagta gatgaagtcg agactgaaga aatcaaacaa
4410061 aagactcacg ctcccctcgc tttgacgcag ggttccagtc gtcgttcgcg ccgtcgacgt
4410121 ctgtctggca gctccggcct gtcgttaagc cttccggtat cggatcccat cctccccgat
4410181 gccatggtcc gcactttgcg agcctgatca tggtcaacca gcttccccgc aacaggccat
4410241 actcggtgag cgcatcgacg gcgtactgac tacaggtagg gacaaagcgg cacgacgccg
4410301 gtcgtagcgg cgaaagcatg tgccgataga cctggataac gaaaatcaac ccccgcgctg
4410361 atgctctacc ggtaacccgg accacgcgcc cacagctttg cctagacaga ctcaccgatc
4410421 actacctgcc agttcgacag ccctccgcaa gccgcatcgc agttgctgct ccaaccgagc
4410481 cgaggagaca tgccggctgc tcggcagcgc gcggatcacc acatgatcgg acgggtggag
4410541 ttctttgacg atcgacccag ccacgtgccg cagccgacgt gccacgcggt ggcgttccac
4410601 ggccgacccc accgacttgg cgataatcag tccgacgcgc ggcccaccgc cactcccacg
4410661 ccaccaataa acgaccatgt cagaccgcac ggtacgcatc ccgtgcttca ccgttgtttc
4410721 aaaatccgct gaccgcctca tgcggttgcg tgcacgaagc accgcaaata agcccggtgt
4410781 tgcaatcaag cactgagcgt gcgccgaccc ttgcgtcgcc ggctggacac aattgacctc
4410841 ccggcgcggg tacgcatccg taagcggaaa ccgtgaacac gagctcgccg ccggttgttc
4410901 ggctggaagg tccttttgcc cttggtcacg ggcgtctcct cgctatgtct ggcaacatca
4410961 ccatccggcc actcactgcc ttccaactcg attggcccgc gggacagtcg gaggtggttt
4411021 tcgctgctgg ccggcgcggt ccctggacta atccaggtcg cagccgcatc gccgactttc
4411081 gggcgactgt tcgagggtac ttacgcgcct tcgcctggtc aaacctcgcc cacccggcaa
4411141 ccgcttcagg gcatcctgcc cgctaagctg ctcaccatcc gtacacccga gaccgccaca
4411201 ctcacaaaga acccaccaca acgcaaaaca acggttggca gccgtacgga aaactgttag
4411261 cttcgggcgg tgtagttatc acgccgtttc agcgtggaaa cggcactcga caatcaagcg
4411321 aggatggcgg atcgactagc ggcccggaca acttgaaccg ggtgttttca acacgaggat
4411381 cgcgagccgt tgccggtagg ttgcggctgg ttatcgacgg tactgtccac atttgtggat
4411441 agccatgtgg acagttcacc tgcccacaac aacggttgta gctcgacccg gaaccaagac
4411501 ccggaactaa cgagaaccag ggagatacgt cg
//